data_8S4W
# 
_entry.id   8S4W 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8S4W         pdb_00008s4w 10.2210/pdb8s4w/pdb 
WWPDB D_1292136821 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-03-05 ? 
2 'Structure model' 1 1 2025-03-26 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  2 'Structure model' '_citation.country'                 
2  2 'Structure model' '_citation.journal_abbrev'          
3  2 'Structure model' '_citation.journal_id_ASTM'         
4  2 'Structure model' '_citation.journal_id_CSD'          
5  2 'Structure model' '_citation.journal_id_ISSN'         
6  2 'Structure model' '_citation.journal_volume'          
7  2 'Structure model' '_citation.page_first'              
8  2 'Structure model' '_citation.page_last'               
9  2 'Structure model' '_citation.pdbx_database_id_DOI'    
10 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
11 2 'Structure model' '_citation.title'                   
12 2 'Structure model' '_citation.year'                    
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8S4W 
_pdbx_database_status.recvd_initial_deposition_date   2024-02-22 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              Lari.Lehtio@oulu.fi 
_pdbx_contact_author.name_first         Lari 
_pdbx_contact_author.name_last          Lehtio 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-7250-832X 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Bosetti, C.' 1 ? 
'Lehtio, L.'  2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   FR 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Eur.J.Med.Chem. 
_citation.journal_id_ASTM           EJMCA5 
_citation.journal_id_CSD            0493 
_citation.journal_id_ISSN           0223-5234 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            288 
_citation.language                  ? 
_citation.page_first                117397 
_citation.page_last                 117397 
_citation.title                     
'Substitutions at the C-8 position of quinazolin-4-ones improve the potency of nicotinamide site binding tankyrase inhibitors.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.ejmech.2025.117397 
_citation.pdbx_database_id_PubMed   39983556 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Bosetti, C.'     1  ? 
primary 'Kampasis, D.'    2  ? 
primary 'Brinch, S.A.'    3  ? 
primary 'Galera-Prat, A.' 4  ? 
primary 'Karelou, M.'     5  ? 
primary 'Dhakar, S.S.'    6  ? 
primary 'Alaviuhkola, J.' 7  ? 
primary 'Waaler, J.'      8  ? 
primary 'Lehtio, L.'      9  ? 
primary 'Kostakis, I.K.'  10 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Poly [ADP-ribose] polymerase tankyrase-2'                                                                    
19482.053 1  2.4.2.30,2.4.2.- ? ? 
;Chymotrypsin was included in the crystallization mixture. Consequently, there aren't missing residues, but a cut in the protein chain.
;
2 polymer     man 'Poly [ADP-ribose] polymerase tankyrase-2'                                                                    
5364.037  1  2.4.2.30,2.4.2.- ? ? 
;Chymotrypsin was included in the crystallization mixture. Consequently, there aren't missing residues, but a cut in the protein chain.
;
3 non-polymer syn '(2~{R})-~{N}-[2-(4-~{tert}-butylphenyl)-4-oxidanylidene-3~{H}-quinazolin-8-yl]-2,3-bis(oxidanyl)propanamide' 
381.425   1  ?                ? ? ? 
4 non-polymer syn 'ZINC ION'                                                                                                    
65.409    1  ?                ? ? ? 
5 non-polymer syn 'SULFATE ION'                                                                                                 
96.063    2  ?                ? ? ? 
6 water       nat water                                                                                                         
18.015    86 ?                ? ? ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
1 
;ADP-ribosyltransferase diphtheria toxin-like 6,ARTD6,Poly [ADP-ribose] polymerase 5B,Protein poly-ADP-ribosyltransferase tankyrase-2,TNKS-2,TRF1-interacting ankyrin-related ADP-ribose polymerase 2,Tankyrase II,Tankyrase-2,TANK2,Tankyrase-like protein,Tankyrase-related protein
;
2 
;ADP-ribosyltransferase diphtheria toxin-like 6,ARTD6,Poly [ADP-ribose] polymerase 5B,Protein poly-ADP-ribosyltransferase tankyrase-2,TNKS-2,TRF1-interacting ankyrin-related ADP-ribose polymerase 2,Tankyrase II,Tankyrase-2,TANK2,Tankyrase-like protein,Tankyrase-related protein
;
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;SMLNTSGSGTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNH
ANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTL
GKSFLQFSAMK
;
;SMLNTSGSGTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNH
ANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTL
GKSFLQFSAMK
;
A ? 
2 'polypeptide(L)' no no MAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPEG MAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPEG E ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 '(2~{R})-~{N}-[2-(4-~{tert}-butylphenyl)-4-oxidanylidene-3~{H}-quinazolin-8-yl]-2,3-bis(oxidanyl)propanamide' A1H44 
4 'ZINC ION'                                                                                                    ZN    
5 'SULFATE ION'                                                                                                 SO4   
6 water                                                                                                         HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   MET n 
1 3   LEU n 
1 4   ASN n 
1 5   THR n 
1 6   SER n 
1 7   GLY n 
1 8   SER n 
1 9   GLY n 
1 10  THR n 
1 11  ILE n 
1 12  LEU n 
1 13  ILE n 
1 14  ASP n 
1 15  LEU n 
1 16  SER n 
1 17  PRO n 
1 18  ASP n 
1 19  ASP n 
1 20  LYS n 
1 21  GLU n 
1 22  PHE n 
1 23  GLN n 
1 24  SER n 
1 25  VAL n 
1 26  GLU n 
1 27  GLU n 
1 28  GLU n 
1 29  MET n 
1 30  GLN n 
1 31  SER n 
1 32  THR n 
1 33  VAL n 
1 34  ARG n 
1 35  GLU n 
1 36  HIS n 
1 37  ARG n 
1 38  ASP n 
1 39  GLY n 
1 40  GLY n 
1 41  HIS n 
1 42  ALA n 
1 43  GLY n 
1 44  GLY n 
1 45  ILE n 
1 46  PHE n 
1 47  ASN n 
1 48  ARG n 
1 49  TYR n 
1 50  ASN n 
1 51  ILE n 
1 52  LEU n 
1 53  LYS n 
1 54  ILE n 
1 55  GLN n 
1 56  LYS n 
1 57  VAL n 
1 58  CYS n 
1 59  ASN n 
1 60  LYS n 
1 61  LYS n 
1 62  LEU n 
1 63  TRP n 
1 64  GLU n 
1 65  ARG n 
1 66  TYR n 
1 67  THR n 
1 68  HIS n 
1 69  ARG n 
1 70  ARG n 
1 71  LYS n 
1 72  GLU n 
1 73  VAL n 
1 74  SER n 
1 75  GLU n 
1 76  GLU n 
1 77  ASN n 
1 78  HIS n 
1 79  ASN n 
1 80  HIS n 
1 81  ALA n 
1 82  ASN n 
1 83  GLU n 
1 84  ARG n 
1 85  MET n 
1 86  LEU n 
1 87  PHE n 
1 88  HIS n 
1 89  GLY n 
1 90  SER n 
1 91  PRO n 
1 92  PHE n 
1 93  VAL n 
1 94  ASN n 
1 95  ALA n 
1 96  ILE n 
1 97  ILE n 
1 98  HIS n 
1 99  LYS n 
1 100 GLY n 
1 101 PHE n 
1 102 ASP n 
1 103 GLU n 
1 104 ARG n 
1 105 HIS n 
1 106 ALA n 
1 107 TYR n 
1 108 ILE n 
1 109 GLY n 
1 110 GLY n 
1 111 MET n 
1 112 PHE n 
1 113 GLY n 
1 114 ALA n 
1 115 GLY n 
1 116 ILE n 
1 117 TYR n 
1 118 PHE n 
1 119 ALA n 
1 120 GLU n 
1 121 ASN n 
1 122 SER n 
1 123 SER n 
1 124 LYS n 
1 125 SER n 
1 126 ASN n 
1 127 GLN n 
1 128 TYR n 
1 129 VAL n 
1 130 TYR n 
1 131 GLY n 
1 132 ILE n 
1 133 GLY n 
1 134 GLY n 
1 135 GLY n 
1 136 THR n 
1 137 GLY n 
1 138 CYS n 
1 139 PRO n 
1 140 VAL n 
1 141 HIS n 
1 142 LYS n 
1 143 ASP n 
1 144 ARG n 
1 145 SER n 
1 146 CYS n 
1 147 TYR n 
1 148 ILE n 
1 149 CYS n 
1 150 HIS n 
1 151 ARG n 
1 152 GLN n 
1 153 LEU n 
1 154 LEU n 
1 155 PHE n 
1 156 CYS n 
1 157 ARG n 
1 158 VAL n 
1 159 THR n 
1 160 LEU n 
1 161 GLY n 
1 162 LYS n 
1 163 SER n 
1 164 PHE n 
1 165 LEU n 
1 166 GLN n 
1 167 PHE n 
1 168 SER n 
1 169 ALA n 
1 170 MET n 
1 171 LYS n 
2 1   MET n 
2 2   ALA n 
2 3   HIS n 
2 4   SER n 
2 5   PRO n 
2 6   PRO n 
2 7   GLY n 
2 8   HIS n 
2 9   HIS n 
2 10  SER n 
2 11  VAL n 
2 12  THR n 
2 13  GLY n 
2 14  ARG n 
2 15  PRO n 
2 16  SER n 
2 17  VAL n 
2 18  ASN n 
2 19  GLY n 
2 20  LEU n 
2 21  ALA n 
2 22  LEU n 
2 23  ALA n 
2 24  GLU n 
2 25  TYR n 
2 26  VAL n 
2 27  ILE n 
2 28  TYR n 
2 29  ARG n 
2 30  GLY n 
2 31  GLU n 
2 32  GLN n 
2 33  ALA n 
2 34  TYR n 
2 35  PRO n 
2 36  GLU n 
2 37  TYR n 
2 38  LEU n 
2 39  ILE n 
2 40  THR n 
2 41  TYR n 
2 42  GLN n 
2 43  ILE n 
2 44  MET n 
2 45  ARG n 
2 46  PRO n 
2 47  GLU n 
2 48  GLY n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 171 human ? 'TNKS2, PARP5B, TANK2, TNKL' ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
'Escherichia coli' 562 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 48  human ? 'TNKS2, PARP5B, TANK2, TNKL' ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
'Escherichia coli' 562 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1H44 non-polymer         . 
'(2~{R})-~{N}-[2-(4-~{tert}-butylphenyl)-4-oxidanylidene-3~{H}-quinazolin-8-yl]-2,3-bis(oxidanyl)propanamide' ? 'C21 H23 N3 O4'  
381.425 
ALA   'L-peptide linking' y ALANINE ? 'C3 H7 N O2'     89.093  
ARG   'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 
ASN   'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'    132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS   'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'   121.158 
GLN   'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'   146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY   'peptide linking'   y GLYCINE ? 'C2 H5 N O2'     75.067  
HIS   'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 
HOH   non-polymer         . WATER ? 'H2 O'           18.015  
ILE   'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'    131.173 
LEU   'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'    131.173 
LYS   'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 
MET   'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'  149.211 
PHE   'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'    165.189 
PRO   'L-peptide linking' y PROLINE ? 'C5 H9 N O2'     115.130 
SER   'L-peptide linking' y SERINE ? 'C3 H7 N O3'     105.093 
SO4   non-polymer         . 'SULFATE ION' ? 'O4 S -2'        96.063  
THR   'L-peptide linking' y THREONINE ? 'C4 H9 N O3'     119.119 
TRP   'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'  204.225 
TYR   'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'    181.189 
VAL   'L-peptide linking' y VALINE ? 'C5 H11 N O2'    117.146 
ZN    non-polymer         . 'ZINC ION' ? 'Zn 2'           65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   944  ?    ?   ?   A . n 
A 1 2   MET 2   945  ?    ?   ?   A . n 
A 1 3   LEU 3   946  ?    ?   ?   A . n 
A 1 4   ASN 4   947  ?    ?   ?   A . n 
A 1 5   THR 5   948  ?    ?   ?   A . n 
A 1 6   SER 6   949  ?    ?   ?   A . n 
A 1 7   GLY 7   950  950  GLY GLY A . n 
A 1 8   SER 8   951  951  SER SER A . n 
A 1 9   GLY 9   952  952  GLY GLY A . n 
A 1 10  THR 10  953  953  THR THR A . n 
A 1 11  ILE 11  954  954  ILE ILE A . n 
A 1 12  LEU 12  955  955  LEU LEU A . n 
A 1 13  ILE 13  956  956  ILE ILE A . n 
A 1 14  ASP 14  957  957  ASP ASP A . n 
A 1 15  LEU 15  958  958  LEU LEU A . n 
A 1 16  SER 16  959  959  SER SER A . n 
A 1 17  PRO 17  960  960  PRO PRO A . n 
A 1 18  ASP 18  961  961  ASP ASP A . n 
A 1 19  ASP 19  962  962  ASP ASP A . n 
A 1 20  LYS 20  963  963  LYS LYS A . n 
A 1 21  GLU 21  964  964  GLU GLU A . n 
A 1 22  PHE 22  965  965  PHE PHE A . n 
A 1 23  GLN 23  966  966  GLN GLN A . n 
A 1 24  SER 24  967  967  SER SER A . n 
A 1 25  VAL 25  968  968  VAL VAL A . n 
A 1 26  GLU 26  969  969  GLU GLU A . n 
A 1 27  GLU 27  970  970  GLU GLU A . n 
A 1 28  GLU 28  971  971  GLU GLU A . n 
A 1 29  MET 29  972  972  MET MET A . n 
A 1 30  GLN 30  973  973  GLN GLN A . n 
A 1 31  SER 31  974  974  SER SER A . n 
A 1 32  THR 32  975  975  THR THR A . n 
A 1 33  VAL 33  976  976  VAL VAL A . n 
A 1 34  ARG 34  977  977  ARG ARG A . n 
A 1 35  GLU 35  978  978  GLU GLU A . n 
A 1 36  HIS 36  979  979  HIS HIS A . n 
A 1 37  ARG 37  980  980  ARG ARG A . n 
A 1 38  ASP 38  981  981  ASP ASP A . n 
A 1 39  GLY 39  982  982  GLY GLY A . n 
A 1 40  GLY 40  983  983  GLY GLY A . n 
A 1 41  HIS 41  984  984  HIS HIS A . n 
A 1 42  ALA 42  985  985  ALA ALA A . n 
A 1 43  GLY 43  986  986  GLY GLY A . n 
A 1 44  GLY 44  987  987  GLY GLY A . n 
A 1 45  ILE 45  988  988  ILE ILE A . n 
A 1 46  PHE 46  989  989  PHE PHE A . n 
A 1 47  ASN 47  990  990  ASN ASN A . n 
A 1 48  ARG 48  991  991  ARG ARG A . n 
A 1 49  TYR 49  992  992  TYR TYR A . n 
A 1 50  ASN 50  993  993  ASN ASN A . n 
A 1 51  ILE 51  994  994  ILE ILE A . n 
A 1 52  LEU 52  995  995  LEU LEU A . n 
A 1 53  LYS 53  996  996  LYS LYS A . n 
A 1 54  ILE 54  997  997  ILE ILE A . n 
A 1 55  GLN 55  998  998  GLN GLN A . n 
A 1 56  LYS 56  999  999  LYS LYS A . n 
A 1 57  VAL 57  1000 1000 VAL VAL A . n 
A 1 58  CYS 58  1001 1001 CYS CYS A . n 
A 1 59  ASN 59  1002 1002 ASN ASN A . n 
A 1 60  LYS 60  1003 1003 LYS LYS A . n 
A 1 61  LYS 61  1004 1004 LYS LYS A . n 
A 1 62  LEU 62  1005 1005 LEU LEU A . n 
A 1 63  TRP 63  1006 1006 TRP TRP A . n 
A 1 64  GLU 64  1007 1007 GLU GLU A . n 
A 1 65  ARG 65  1008 1008 ARG ARG A . n 
A 1 66  TYR 66  1009 1009 TYR TYR A . n 
A 1 67  THR 67  1010 1010 THR THR A . n 
A 1 68  HIS 68  1011 1011 HIS HIS A . n 
A 1 69  ARG 69  1012 1012 ARG ARG A . n 
A 1 70  ARG 70  1013 1013 ARG ARG A . n 
A 1 71  LYS 71  1014 1014 LYS LYS A . n 
A 1 72  GLU 72  1015 1015 GLU GLU A . n 
A 1 73  VAL 73  1016 1016 VAL VAL A . n 
A 1 74  SER 74  1017 1017 SER SER A . n 
A 1 75  GLU 75  1018 1018 GLU GLU A . n 
A 1 76  GLU 76  1019 1019 GLU GLU A . n 
A 1 77  ASN 77  1020 1020 ASN ASN A . n 
A 1 78  HIS 78  1021 1021 HIS HIS A . n 
A 1 79  ASN 79  1022 1022 ASN ASN A . n 
A 1 80  HIS 80  1023 1023 HIS HIS A . n 
A 1 81  ALA 81  1024 1024 ALA ALA A . n 
A 1 82  ASN 82  1025 1025 ASN ASN A . n 
A 1 83  GLU 83  1026 1026 GLU GLU A . n 
A 1 84  ARG 84  1027 1027 ARG ARG A . n 
A 1 85  MET 85  1028 1028 MET MET A . n 
A 1 86  LEU 86  1029 1029 LEU LEU A . n 
A 1 87  PHE 87  1030 1030 PHE PHE A . n 
A 1 88  HIS 88  1031 1031 HIS HIS A . n 
A 1 89  GLY 89  1032 1032 GLY GLY A . n 
A 1 90  SER 90  1033 1033 SER SER A . n 
A 1 91  PRO 91  1034 1034 PRO PRO A . n 
A 1 92  PHE 92  1035 1035 PHE PHE A . n 
A 1 93  VAL 93  1036 1036 VAL VAL A . n 
A 1 94  ASN 94  1037 1037 ASN ASN A . n 
A 1 95  ALA 95  1038 1038 ALA ALA A . n 
A 1 96  ILE 96  1039 1039 ILE ILE A . n 
A 1 97  ILE 97  1040 1040 ILE ILE A . n 
A 1 98  HIS 98  1041 1041 HIS HIS A . n 
A 1 99  LYS 99  1042 1042 LYS LYS A . n 
A 1 100 GLY 100 1043 1043 GLY GLY A . n 
A 1 101 PHE 101 1044 1044 PHE PHE A . n 
A 1 102 ASP 102 1045 1045 ASP ASP A . n 
A 1 103 GLU 103 1046 1046 GLU GLU A . n 
A 1 104 ARG 104 1047 1047 ARG ARG A . n 
A 1 105 HIS 105 1048 1048 HIS HIS A . n 
A 1 106 ALA 106 1049 1049 ALA ALA A . n 
A 1 107 TYR 107 1050 1050 TYR TYR A . n 
A 1 108 ILE 108 1051 1051 ILE ILE A . n 
A 1 109 GLY 109 1052 1052 GLY GLY A . n 
A 1 110 GLY 110 1053 1053 GLY GLY A . n 
A 1 111 MET 111 1054 1054 MET MET A . n 
A 1 112 PHE 112 1055 1055 PHE PHE A . n 
A 1 113 GLY 113 1056 1056 GLY GLY A . n 
A 1 114 ALA 114 1057 1057 ALA ALA A . n 
A 1 115 GLY 115 1058 1058 GLY GLY A . n 
A 1 116 ILE 116 1059 1059 ILE ILE A . n 
A 1 117 TYR 117 1060 1060 TYR TYR A . n 
A 1 118 PHE 118 1061 1061 PHE PHE A . n 
A 1 119 ALA 119 1062 1062 ALA ALA A . n 
A 1 120 GLU 120 1063 1063 GLU GLU A . n 
A 1 121 ASN 121 1064 1064 ASN ASN A . n 
A 1 122 SER 122 1065 1065 SER SER A . n 
A 1 123 SER 123 1066 1066 SER SER A . n 
A 1 124 LYS 124 1067 1067 LYS LYS A . n 
A 1 125 SER 125 1068 1068 SER SER A . n 
A 1 126 ASN 126 1069 1069 ASN ASN A . n 
A 1 127 GLN 127 1070 1070 GLN GLN A . n 
A 1 128 TYR 128 1071 1071 TYR TYR A . n 
A 1 129 VAL 129 1072 1072 VAL VAL A . n 
A 1 130 TYR 130 1073 1073 TYR TYR A . n 
A 1 131 GLY 131 1074 1074 GLY GLY A . n 
A 1 132 ILE 132 1075 1075 ILE ILE A . n 
A 1 133 GLY 133 1076 1076 GLY GLY A . n 
A 1 134 GLY 134 1077 1077 GLY GLY A . n 
A 1 135 GLY 135 1078 1078 GLY GLY A . n 
A 1 136 THR 136 1079 1079 THR THR A . n 
A 1 137 GLY 137 1080 1080 GLY GLY A . n 
A 1 138 CYS 138 1081 1081 CYS CYS A . n 
A 1 139 PRO 139 1082 1082 PRO PRO A . n 
A 1 140 VAL 140 1083 1083 VAL VAL A . n 
A 1 141 HIS 141 1084 1084 HIS HIS A . n 
A 1 142 LYS 142 1085 1085 LYS LYS A . n 
A 1 143 ASP 143 1086 1086 ASP ASP A . n 
A 1 144 ARG 144 1087 1087 ARG ARG A . n 
A 1 145 SER 145 1088 1088 SER SER A . n 
A 1 146 CYS 146 1089 1089 CYS CYS A . n 
A 1 147 TYR 147 1090 1090 TYR TYR A . n 
A 1 148 ILE 148 1091 1091 ILE ILE A . n 
A 1 149 CYS 149 1092 1092 CYS CYS A . n 
A 1 150 HIS 150 1093 1093 HIS HIS A . n 
A 1 151 ARG 151 1094 1094 ARG ARG A . n 
A 1 152 GLN 152 1095 1095 GLN GLN A . n 
A 1 153 LEU 153 1096 1096 LEU LEU A . n 
A 1 154 LEU 154 1097 1097 LEU LEU A . n 
A 1 155 PHE 155 1098 1098 PHE PHE A . n 
A 1 156 CYS 156 1099 1099 CYS CYS A . n 
A 1 157 ARG 157 1100 1100 ARG ARG A . n 
A 1 158 VAL 158 1101 1101 VAL VAL A . n 
A 1 159 THR 159 1102 1102 THR THR A . n 
A 1 160 LEU 160 1103 1103 LEU LEU A . n 
A 1 161 GLY 161 1104 1104 GLY GLY A . n 
A 1 162 LYS 162 1105 1105 LYS LYS A . n 
A 1 163 SER 163 1106 1106 SER SER A . n 
A 1 164 PHE 164 1107 1107 PHE PHE A . n 
A 1 165 LEU 165 1108 1108 LEU LEU A . n 
A 1 166 GLN 166 1109 1109 GLN GLN A . n 
A 1 167 PHE 167 1110 1110 PHE PHE A . n 
A 1 168 SER 168 1111 1111 SER SER A . n 
A 1 169 ALA 169 1112 ?    ?   ?   A . n 
A 1 170 MET 170 1113 ?    ?   ?   A . n 
A 1 171 LYS 171 1114 ?    ?   ?   A . n 
B 2 1   MET 1   1115 1115 MET MET E . n 
B 2 2   ALA 2   1116 1116 ALA ALA E . n 
B 2 3   HIS 3   1117 1117 HIS HIS E . n 
B 2 4   SER 4   1118 1118 SER SER E . n 
B 2 5   PRO 5   1119 1119 PRO PRO E . n 
B 2 6   PRO 6   1120 1120 PRO PRO E . n 
B 2 7   GLY 7   1121 1121 GLY GLY E . n 
B 2 8   HIS 8   1122 1122 HIS HIS E . n 
B 2 9   HIS 9   1123 1123 HIS HIS E . n 
B 2 10  SER 10  1124 1124 SER SER E . n 
B 2 11  VAL 11  1125 1125 VAL VAL E . n 
B 2 12  THR 12  1126 1126 THR THR E . n 
B 2 13  GLY 13  1127 1127 GLY GLY E . n 
B 2 14  ARG 14  1128 1128 ARG ARG E . n 
B 2 15  PRO 15  1129 1129 PRO PRO E . n 
B 2 16  SER 16  1130 1130 SER SER E . n 
B 2 17  VAL 17  1131 1131 VAL VAL E . n 
B 2 18  ASN 18  1132 1132 ASN ASN E . n 
B 2 19  GLY 19  1133 1133 GLY GLY E . n 
B 2 20  LEU 20  1134 1134 LEU LEU E . n 
B 2 21  ALA 21  1135 1135 ALA ALA E . n 
B 2 22  LEU 22  1136 1136 LEU LEU E . n 
B 2 23  ALA 23  1137 1137 ALA ALA E . n 
B 2 24  GLU 24  1138 1138 GLU GLU E . n 
B 2 25  TYR 25  1139 1139 TYR TYR E . n 
B 2 26  VAL 26  1140 1140 VAL VAL E . n 
B 2 27  ILE 27  1141 1141 ILE ILE E . n 
B 2 28  TYR 28  1142 1142 TYR TYR E . n 
B 2 29  ARG 29  1143 1143 ARG ARG E . n 
B 2 30  GLY 30  1144 1144 GLY GLY E . n 
B 2 31  GLU 31  1145 1145 GLU GLU E . n 
B 2 32  GLN 32  1146 1146 GLN GLN E . n 
B 2 33  ALA 33  1147 1147 ALA ALA E . n 
B 2 34  TYR 34  1148 1148 TYR TYR E . n 
B 2 35  PRO 35  1149 1149 PRO PRO E . n 
B 2 36  GLU 36  1150 1150 GLU GLU E . n 
B 2 37  TYR 37  1151 1151 TYR TYR E . n 
B 2 38  LEU 38  1152 1152 LEU LEU E . n 
B 2 39  ILE 39  1153 1153 ILE ILE E . n 
B 2 40  THR 40  1154 1154 THR THR E . n 
B 2 41  TYR 41  1155 1155 TYR TYR E . n 
B 2 42  GLN 42  1156 1156 GLN GLN E . n 
B 2 43  ILE 43  1157 1157 ILE ILE E . n 
B 2 44  MET 44  1158 1158 MET MET E . n 
B 2 45  ARG 45  1159 1159 ARG ARG E . n 
B 2 46  PRO 46  1160 1160 PRO PRO E . n 
B 2 47  GLU 47  1161 1161 GLU GLU E . n 
B 2 48  GLY 48  1162 ?    ?   ?   E . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1H44 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1H44 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 3 A1H44 1  1201 1203 A1H44 365 A . 
D 4 ZN    1  1202 1    ZN    ZN  A . 
E 5 SO4   1  1203 1    SO4   SO4 A . 
F 5 SO4   1  1204 2    SO4   SO4 A . 
G 6 HOH   1  1301 37   HOH   HOH A . 
G 6 HOH   2  1302 84   HOH   HOH A . 
G 6 HOH   3  1303 32   HOH   HOH A . 
G 6 HOH   4  1304 38   HOH   HOH A . 
G 6 HOH   5  1305 68   HOH   HOH A . 
G 6 HOH   6  1306 69   HOH   HOH A . 
G 6 HOH   7  1307 86   HOH   HOH A . 
G 6 HOH   8  1308 81   HOH   HOH A . 
G 6 HOH   9  1309 65   HOH   HOH A . 
G 6 HOH   10 1310 45   HOH   HOH A . 
G 6 HOH   11 1311 78   HOH   HOH A . 
G 6 HOH   12 1312 3    HOH   HOH A . 
G 6 HOH   13 1313 34   HOH   HOH A . 
G 6 HOH   14 1314 79   HOH   HOH A . 
G 6 HOH   15 1315 72   HOH   HOH A . 
G 6 HOH   16 1316 7    HOH   HOH A . 
G 6 HOH   17 1317 21   HOH   HOH A . 
G 6 HOH   18 1318 39   HOH   HOH A . 
G 6 HOH   19 1319 4    HOH   HOH A . 
G 6 HOH   20 1320 9    HOH   HOH A . 
G 6 HOH   21 1321 31   HOH   HOH A . 
G 6 HOH   22 1322 27   HOH   HOH A . 
G 6 HOH   23 1323 40   HOH   HOH A . 
G 6 HOH   24 1324 5    HOH   HOH A . 
G 6 HOH   25 1325 23   HOH   HOH A . 
G 6 HOH   26 1326 47   HOH   HOH A . 
G 6 HOH   27 1327 71   HOH   HOH A . 
G 6 HOH   28 1328 80   HOH   HOH A . 
G 6 HOH   29 1329 19   HOH   HOH A . 
G 6 HOH   30 1330 42   HOH   HOH A . 
G 6 HOH   31 1331 43   HOH   HOH A . 
G 6 HOH   32 1332 26   HOH   HOH A . 
G 6 HOH   33 1333 48   HOH   HOH A . 
G 6 HOH   34 1334 77   HOH   HOH A . 
G 6 HOH   35 1335 20   HOH   HOH A . 
G 6 HOH   36 1336 28   HOH   HOH A . 
G 6 HOH   37 1337 58   HOH   HOH A . 
G 6 HOH   38 1338 70   HOH   HOH A . 
G 6 HOH   39 1339 17   HOH   HOH A . 
G 6 HOH   40 1340 59   HOH   HOH A . 
G 6 HOH   41 1341 22   HOH   HOH A . 
G 6 HOH   42 1342 51   HOH   HOH A . 
G 6 HOH   43 1343 46   HOH   HOH A . 
G 6 HOH   44 1344 1    HOH   HOH A . 
G 6 HOH   45 1345 30   HOH   HOH A . 
G 6 HOH   46 1346 66   HOH   HOH A . 
G 6 HOH   47 1347 54   HOH   HOH A . 
G 6 HOH   48 1348 13   HOH   HOH A . 
G 6 HOH   49 1349 67   HOH   HOH A . 
G 6 HOH   50 1350 61   HOH   HOH A . 
G 6 HOH   51 1351 16   HOH   HOH A . 
G 6 HOH   52 1352 18   HOH   HOH A . 
G 6 HOH   53 1353 8    HOH   HOH A . 
G 6 HOH   54 1354 75   HOH   HOH A . 
G 6 HOH   55 1355 10   HOH   HOH A . 
G 6 HOH   56 1356 85   HOH   HOH A . 
G 6 HOH   57 1357 12   HOH   HOH A . 
G 6 HOH   58 1358 14   HOH   HOH A . 
G 6 HOH   59 1359 15   HOH   HOH A . 
G 6 HOH   60 1360 25   HOH   HOH A . 
G 6 HOH   61 1361 64   HOH   HOH A . 
G 6 HOH   62 1362 53   HOH   HOH A . 
G 6 HOH   63 1363 44   HOH   HOH A . 
G 6 HOH   64 1364 60   HOH   HOH A . 
G 6 HOH   65 1365 73   HOH   HOH A . 
G 6 HOH   66 1366 24   HOH   HOH A . 
G 6 HOH   67 1367 57   HOH   HOH A . 
G 6 HOH   68 1368 76   HOH   HOH A . 
G 6 HOH   69 1369 63   HOH   HOH A . 
G 6 HOH   70 1370 41   HOH   HOH A . 
G 6 HOH   71 1371 52   HOH   HOH A . 
G 6 HOH   72 1372 50   HOH   HOH A . 
H 6 HOH   1  1201 82   HOH   HOH E . 
H 6 HOH   2  1202 83   HOH   HOH E . 
H 6 HOH   3  1203 33   HOH   HOH E . 
H 6 HOH   4  1204 55   HOH   HOH E . 
H 6 HOH   5  1205 49   HOH   HOH E . 
H 6 HOH   6  1206 6    HOH   HOH E . 
H 6 HOH   7  1207 11   HOH   HOH E . 
H 6 HOH   8  1208 62   HOH   HOH E . 
H 6 HOH   9  1209 29   HOH   HOH E . 
H 6 HOH   10 1210 2    HOH   HOH E . 
H 6 HOH   11 1211 74   HOH   HOH E . 
H 6 HOH   12 1212 56   HOH   HOH E . 
H 6 HOH   13 1213 35   HOH   HOH E . 
H 6 HOH   14 1214 36   HOH   HOH E . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 E VAL 1131 ? CG1 ? B VAL 17 CG1 
2 1 Y 1 E VAL 1131 ? CG2 ? B VAL 17 CG2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XSCALE ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8S4W 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     66.600 
_cell.length_a_esd                 ? 
_cell.length_b                     66.600 
_cell.length_b_esd                 ? 
_cell.length_c                     120.586 
_cell.length_c_esd                 ? 
_cell.volume                       534866.438 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8S4W 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                92 
_symmetry.space_group_name_Hall            'P 4abw 2nw' 
_symmetry.space_group_name_H-M             'P 41 21 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8S4W 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.69 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          54.32 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '100 mM Tris pH 8.5, 22% PEG3350, 200 mM Li2SO4, 250 mM NaCl, 20% glycerol' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            277.15 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 4M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-11-21 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.96770 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'ESRF BEAMLINE MASSIF-3' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.96770 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   MASSIF-3 
_diffrn_source.pdbx_synchrotron_site       ESRF 
# 
_reflns.B_iso_Wilson_estimate                          43.67 
_reflns.entry_id                                       8S4W 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.12 
_reflns.d_resolution_low                               50 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     16027 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.5 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                12.659 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          10.11 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.997 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.12 
_reflns_shell.d_res_low                                     2.25 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             33204 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.797 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               48.37 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8S4W 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.12 
_refine.ls_d_res_low                             44.70 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     16007 
_refine.ls_number_reflns_R_free                  801 
_refine.ls_number_reflns_R_work                  15206 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.34 
_refine.ls_percent_reflns_R_free                 5.00 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1922 
_refine.ls_R_factor_R_free                       0.2464 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1892 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.35 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 26.9146 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.3526 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.12 
_refine_hist.d_res_low                        44.70 
_refine_hist.number_atoms_solvent             86 
_refine_hist.number_atoms_total               1797 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1672 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         39 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0115  ? 1759 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.1161  ? 2373 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0552  ? 232  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0092  ? 310  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 14.3046 ? 639  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.12 2.25  . . 128 2410 96.54 . . . . 0.3045 . . . . . . . . . . . 0.3634 
'X-RAY DIFFRACTION' 2.25 2.42  . . 130 2484 99.77 . . . . 0.3038 . . . . . . . . . . . 0.3129 
'X-RAY DIFFRACTION' 2.42 2.67  . . 132 2505 99.96 . . . . 0.2356 . . . . . . . . . . . 0.3117 
'X-RAY DIFFRACTION' 2.67 3.05  . . 133 2529 99.92 . . . . 0.2256 . . . . . . . . . . . 0.3251 
'X-RAY DIFFRACTION' 3.05 3.85  . . 134 2561 99.96 . . . . 0.1736 . . . . . . . . . . . 0.2562 
'X-RAY DIFFRACTION' 3.85 44.70 . . 144 2717 99.90 . . . . 0.1424 . . . . . . . . . . . 0.1688 
# 
_struct.entry_id                     8S4W 
_struct.title                        'Tankyrase 2 in complex with a quinazolin-4-one inhibitor' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8S4W 
_struct_keywords.text            'Inhibitor, transferase, Tankyrase 2' 
_struct_keywords.pdbx_keywords   TRANSFERASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 5 ? 
F N N 5 ? 
G N N 6 ? 
H N N 6 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP TNKS2_HUMAN Q9H2K2 ? 1 
;LNTSGSGTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHAN
ERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGK
SFLQFSAMK
;
946  
2 UNP TNKS2_HUMAN Q9H2K2 ? 2 MAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPEG 1115 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8S4W A 3 ? 171 ? Q9H2K2 946  ? 1114 ? 946  1114 
2 2 8S4W E 1 ? 48  ? Q9H2K2 1115 ? 1162 ? 1115 1162 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8S4W SER A 1 ? UNP Q9H2K2 ? ? 'expression tag' 944 1 
1 8S4W MET A 2 ? UNP Q9H2K2 ? ? 'expression tag' 945 2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 6430  ? 
1 MORE         -65   ? 
1 'SSA (A^2)'  10230 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 ASP A 19  ? THR A 32  ? ASP A 962  THR A 975  1 ? 14 
HELX_P HELX_P2 AA2 ASN A 59  ? GLU A 76  ? ASN A 1002 GLU A 1019 1 ? 18 
HELX_P HELX_P3 AA3 PHE A 92  ? GLY A 100 ? PHE A 1035 GLY A 1043 1 ? 9  
HELX_P HELX_P4 AA4 ASN A 121 ? ASN A 126 ? ASN A 1064 ASN A 1069 1 ? 6  
HELX_P HELX_P5 AA5 GLN A 127 ? VAL A 129 ? GLN A 1070 VAL A 1072 5 ? 3  
HELX_P HELX_P6 AA6 GLY A 131 ? GLY A 135 ? GLY A 1074 GLY A 1078 5 ? 5  
HELX_P HELX_P7 AA7 ARG B 29  ? GLU B 31  ? ARG E 1143 GLU E 1145 5 ? 3  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1 metalc ? ? A CYS 138 SG  ? ? ? 1_555 D ZN . ZN ? ? A CYS 1081 A ZN 1202 1_555 ? ? ? ? ? ? ? 2.362 ? ? 
metalc2 metalc ? ? A HIS 141 ND1 ? ? ? 1_555 D ZN . ZN ? ? A HIS 1084 A ZN 1202 1_555 ? ? ? ? ? ? ? 2.080 ? ? 
metalc3 metalc ? ? A CYS 146 SG  ? ? ? 1_555 D ZN . ZN ? ? A CYS 1089 A ZN 1202 1_555 ? ? ? ? ? ? ? 2.234 ? ? 
metalc4 metalc ? ? A CYS 149 SG  ? ? ? 1_555 D ZN . ZN ? ? A CYS 1092 A ZN 1202 1_555 ? ? ? ? ? ? ? 2.318 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1 SG  ? A CYS 138 ? A CYS 1081 ? 1_555 ZN ? D ZN . ? A ZN 1202 ? 1_555 ND1 ? A HIS 141 ? A HIS 1084 ? 1_555 105.1 ? 
2 SG  ? A CYS 138 ? A CYS 1081 ? 1_555 ZN ? D ZN . ? A ZN 1202 ? 1_555 SG  ? A CYS 146 ? A CYS 1089 ? 1_555 110.1 ? 
3 ND1 ? A HIS 141 ? A HIS 1084 ? 1_555 ZN ? D ZN . ? A ZN 1202 ? 1_555 SG  ? A CYS 146 ? A CYS 1089 ? 1_555 108.2 ? 
4 SG  ? A CYS 138 ? A CYS 1081 ? 1_555 ZN ? D ZN . ? A ZN 1202 ? 1_555 SG  ? A CYS 149 ? A CYS 1092 ? 1_555 112.7 ? 
5 ND1 ? A HIS 141 ? A HIS 1084 ? 1_555 ZN ? D ZN . ? A ZN 1202 ? 1_555 SG  ? A CYS 149 ? A CYS 1092 ? 1_555 106.8 ? 
6 SG  ? A CYS 146 ? A CYS 1089 ? 1_555 ZN ? D ZN . ? A ZN 1202 ? 1_555 SG  ? A CYS 149 ? A CYS 1092 ? 1_555 113.4 ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ILE A 11  ? ASP A 14  ? ILE A 954  ASP A 957  
AA1 2 TYR A 49  ? CYS A 58  ? TYR A 992  CYS A 1001 
AA1 3 ALA B 33  ? ILE B 43  ? ALA E 1147 ILE E 1157 
AA1 4 ARG A 151 ? THR A 159 ? ARG A 1094 THR A 1102 
AA1 5 GLU A 83  ? HIS A 88  ? GLU A 1026 HIS A 1031 
AA2 1 ILE A 116 ? ALA A 119 ? ILE A 1059 ALA A 1062 
AA2 2 GLU B 24  ? ILE B 27  ? GLU E 1138 ILE E 1141 
AA2 3 SER B 10  ? ARG B 14  ? SER E 1124 ARG E 1128 
AA2 4 SER A 163 ? PHE A 167 ? SER A 1106 PHE A 1110 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ILE A 13  ? N ILE A 956  O LYS A 56  ? O LYS A 999  
AA1 2 3 N ASN A 50  ? N ASN A 993  O GLN B 42  ? O GLN E 1156 
AA1 3 4 O ILE B 39  ? O ILE E 1153 N LEU A 153 ? N LEU A 1096 
AA1 4 5 O CYS A 156 ? O CYS A 1099 N LEU A 86  ? N LEU A 1029 
AA2 1 2 N ILE A 116 ? N ILE A 1059 O ILE B 27  ? O ILE E 1141 
AA2 2 3 O GLU B 24  ? O GLU E 1138 N GLY B 13  ? N GLY E 1127 
AA2 3 4 O ARG B 14  ? O ARG E 1128 N GLN A 166 ? N GLN A 1109 
# 
_pdbx_entry_details.entry_id                   8S4W 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   OD1 
_pdbx_validate_close_contact.auth_asym_id_1   A 
_pdbx_validate_close_contact.auth_comp_id_1   ASN 
_pdbx_validate_close_contact.auth_seq_id_1    1022 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   B 
_pdbx_validate_close_contact.auth_atom_id_2   O 
_pdbx_validate_close_contact.auth_asym_id_2   A 
_pdbx_validate_close_contact.auth_comp_id_2   HOH 
_pdbx_validate_close_contact.auth_seq_id_2    1301 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             2.19 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASN A 1002 ? ? -163.91 109.13  
2 1 ASN A 1020 ? ? -149.92 59.87   
3 1 HIS A 1021 ? ? 33.79   54.10   
4 1 SER E 1124 ? ? -170.37 -179.69 
# 
_pdbx_struct_special_symmetry.id              1 
_pdbx_struct_special_symmetry.PDB_model_num   1 
_pdbx_struct_special_symmetry.auth_asym_id    A 
_pdbx_struct_special_symmetry.auth_comp_id    HOH 
_pdbx_struct_special_symmetry.auth_seq_id     1319 
_pdbx_struct_special_symmetry.PDB_ins_code    ? 
_pdbx_struct_special_symmetry.label_asym_id   G 
_pdbx_struct_special_symmetry.label_comp_id   HOH 
_pdbx_struct_special_symmetry.label_seq_id    . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z               
2 -y+1/2,x+1/2,z+1/4  
3 y+1/2,-x+1/2,z+3/4  
4 x+1/2,-y+1/2,-z+3/4 
5 -x+1/2,y+1/2,-z+1/4 
6 -x,-y,z+1/2         
7 y,x,-z              
8 -y,-x,-z+1/2        
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A SER 944  ? A SER 1   
2  1 Y 1 A MET 945  ? A MET 2   
3  1 Y 1 A LEU 946  ? A LEU 3   
4  1 Y 1 A ASN 947  ? A ASN 4   
5  1 Y 1 A THR 948  ? A THR 5   
6  1 Y 1 A SER 949  ? A SER 6   
7  1 Y 1 A ALA 1112 ? A ALA 169 
8  1 Y 1 A MET 1113 ? A MET 170 
9  1 Y 1 A LYS 1114 ? A LYS 171 
10 1 Y 1 E GLY 1162 ? B GLY 48  
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1H44 C10  C  N N 1   
A1H44 C11  C  Y N 2   
A1H44 C14  C  Y N 3   
A1H44 C15  C  Y N 4   
A1H44 C16  C  Y N 5   
A1H44 C17  C  Y N 6   
A1H44 C20  C  N N 7   
A1H44 C21  C  N N 8   
A1H44 C22  C  N N 9   
A1H44 C01  C  Y N 10  
A1H44 C02  C  Y N 11  
A1H44 C03  C  Y N 12  
A1H44 C04  C  Y N 13  
A1H44 C05  C  Y N 14  
A1H44 C06  C  Y N 15  
A1H44 C08  C  N N 16  
A1H44 C18  C  Y N 17  
A1H44 C19  C  N N 18  
A1H44 C23  C  N N 19  
A1H44 C25  C  N R 20  
A1H44 C26  C  N N 21  
A1H44 N07  N  N N 22  
A1H44 N09  N  N N 23  
A1H44 N13  N  N N 24  
A1H44 O12  O  N N 25  
A1H44 O24  O  N N 26  
A1H44 O27  O  N N 27  
A1H44 O28  O  N N 28  
A1H44 H141 H  N N 29  
A1H44 H151 H  N N 30  
A1H44 H171 H  N N 31  
A1H44 H202 H  N N 32  
A1H44 H201 H  N N 33  
A1H44 H203 H  N N 34  
A1H44 H211 H  N N 35  
A1H44 H212 H  N N 36  
A1H44 H213 H  N N 37  
A1H44 H223 H  N N 38  
A1H44 H222 H  N N 39  
A1H44 H221 H  N N 40  
A1H44 H011 H  N N 41  
A1H44 H021 H  N N 42  
A1H44 H031 H  N N 43  
A1H44 H181 H  N N 44  
A1H44 H251 H  N N 45  
A1H44 H261 H  N N 46  
A1H44 H262 H  N N 47  
A1H44 H091 H  N N 48  
A1H44 H131 H  N N 49  
A1H44 H271 H  N N 50  
A1H44 H281 H  N N 51  
ALA   N    N  N N 52  
ALA   CA   C  N S 53  
ALA   C    C  N N 54  
ALA   O    O  N N 55  
ALA   CB   C  N N 56  
ALA   OXT  O  N N 57  
ALA   H    H  N N 58  
ALA   H2   H  N N 59  
ALA   HA   H  N N 60  
ALA   HB1  H  N N 61  
ALA   HB2  H  N N 62  
ALA   HB3  H  N N 63  
ALA   HXT  H  N N 64  
ARG   N    N  N N 65  
ARG   CA   C  N S 66  
ARG   C    C  N N 67  
ARG   O    O  N N 68  
ARG   CB   C  N N 69  
ARG   CG   C  N N 70  
ARG   CD   C  N N 71  
ARG   NE   N  N N 72  
ARG   CZ   C  N N 73  
ARG   NH1  N  N N 74  
ARG   NH2  N  N N 75  
ARG   OXT  O  N N 76  
ARG   H    H  N N 77  
ARG   H2   H  N N 78  
ARG   HA   H  N N 79  
ARG   HB2  H  N N 80  
ARG   HB3  H  N N 81  
ARG   HG2  H  N N 82  
ARG   HG3  H  N N 83  
ARG   HD2  H  N N 84  
ARG   HD3  H  N N 85  
ARG   HE   H  N N 86  
ARG   HH11 H  N N 87  
ARG   HH12 H  N N 88  
ARG   HH21 H  N N 89  
ARG   HH22 H  N N 90  
ARG   HXT  H  N N 91  
ASN   N    N  N N 92  
ASN   CA   C  N S 93  
ASN   C    C  N N 94  
ASN   O    O  N N 95  
ASN   CB   C  N N 96  
ASN   CG   C  N N 97  
ASN   OD1  O  N N 98  
ASN   ND2  N  N N 99  
ASN   OXT  O  N N 100 
ASN   H    H  N N 101 
ASN   H2   H  N N 102 
ASN   HA   H  N N 103 
ASN   HB2  H  N N 104 
ASN   HB3  H  N N 105 
ASN   HD21 H  N N 106 
ASN   HD22 H  N N 107 
ASN   HXT  H  N N 108 
ASP   N    N  N N 109 
ASP   CA   C  N S 110 
ASP   C    C  N N 111 
ASP   O    O  N N 112 
ASP   CB   C  N N 113 
ASP   CG   C  N N 114 
ASP   OD1  O  N N 115 
ASP   OD2  O  N N 116 
ASP   OXT  O  N N 117 
ASP   H    H  N N 118 
ASP   H2   H  N N 119 
ASP   HA   H  N N 120 
ASP   HB2  H  N N 121 
ASP   HB3  H  N N 122 
ASP   HD2  H  N N 123 
ASP   HXT  H  N N 124 
CYS   N    N  N N 125 
CYS   CA   C  N R 126 
CYS   C    C  N N 127 
CYS   O    O  N N 128 
CYS   CB   C  N N 129 
CYS   SG   S  N N 130 
CYS   OXT  O  N N 131 
CYS   H    H  N N 132 
CYS   H2   H  N N 133 
CYS   HA   H  N N 134 
CYS   HB2  H  N N 135 
CYS   HB3  H  N N 136 
CYS   HG   H  N N 137 
CYS   HXT  H  N N 138 
GLN   N    N  N N 139 
GLN   CA   C  N S 140 
GLN   C    C  N N 141 
GLN   O    O  N N 142 
GLN   CB   C  N N 143 
GLN   CG   C  N N 144 
GLN   CD   C  N N 145 
GLN   OE1  O  N N 146 
GLN   NE2  N  N N 147 
GLN   OXT  O  N N 148 
GLN   H    H  N N 149 
GLN   H2   H  N N 150 
GLN   HA   H  N N 151 
GLN   HB2  H  N N 152 
GLN   HB3  H  N N 153 
GLN   HG2  H  N N 154 
GLN   HG3  H  N N 155 
GLN   HE21 H  N N 156 
GLN   HE22 H  N N 157 
GLN   HXT  H  N N 158 
GLU   N    N  N N 159 
GLU   CA   C  N S 160 
GLU   C    C  N N 161 
GLU   O    O  N N 162 
GLU   CB   C  N N 163 
GLU   CG   C  N N 164 
GLU   CD   C  N N 165 
GLU   OE1  O  N N 166 
GLU   OE2  O  N N 167 
GLU   OXT  O  N N 168 
GLU   H    H  N N 169 
GLU   H2   H  N N 170 
GLU   HA   H  N N 171 
GLU   HB2  H  N N 172 
GLU   HB3  H  N N 173 
GLU   HG2  H  N N 174 
GLU   HG3  H  N N 175 
GLU   HE2  H  N N 176 
GLU   HXT  H  N N 177 
GLY   N    N  N N 178 
GLY   CA   C  N N 179 
GLY   C    C  N N 180 
GLY   O    O  N N 181 
GLY   OXT  O  N N 182 
GLY   H    H  N N 183 
GLY   H2   H  N N 184 
GLY   HA2  H  N N 185 
GLY   HA3  H  N N 186 
GLY   HXT  H  N N 187 
HIS   N    N  N N 188 
HIS   CA   C  N S 189 
HIS   C    C  N N 190 
HIS   O    O  N N 191 
HIS   CB   C  N N 192 
HIS   CG   C  Y N 193 
HIS   ND1  N  Y N 194 
HIS   CD2  C  Y N 195 
HIS   CE1  C  Y N 196 
HIS   NE2  N  Y N 197 
HIS   OXT  O  N N 198 
HIS   H    H  N N 199 
HIS   H2   H  N N 200 
HIS   HA   H  N N 201 
HIS   HB2  H  N N 202 
HIS   HB3  H  N N 203 
HIS   HD1  H  N N 204 
HIS   HD2  H  N N 205 
HIS   HE1  H  N N 206 
HIS   HE2  H  N N 207 
HIS   HXT  H  N N 208 
HOH   O    O  N N 209 
HOH   H1   H  N N 210 
HOH   H2   H  N N 211 
ILE   N    N  N N 212 
ILE   CA   C  N S 213 
ILE   C    C  N N 214 
ILE   O    O  N N 215 
ILE   CB   C  N S 216 
ILE   CG1  C  N N 217 
ILE   CG2  C  N N 218 
ILE   CD1  C  N N 219 
ILE   OXT  O  N N 220 
ILE   H    H  N N 221 
ILE   H2   H  N N 222 
ILE   HA   H  N N 223 
ILE   HB   H  N N 224 
ILE   HG12 H  N N 225 
ILE   HG13 H  N N 226 
ILE   HG21 H  N N 227 
ILE   HG22 H  N N 228 
ILE   HG23 H  N N 229 
ILE   HD11 H  N N 230 
ILE   HD12 H  N N 231 
ILE   HD13 H  N N 232 
ILE   HXT  H  N N 233 
LEU   N    N  N N 234 
LEU   CA   C  N S 235 
LEU   C    C  N N 236 
LEU   O    O  N N 237 
LEU   CB   C  N N 238 
LEU   CG   C  N N 239 
LEU   CD1  C  N N 240 
LEU   CD2  C  N N 241 
LEU   OXT  O  N N 242 
LEU   H    H  N N 243 
LEU   H2   H  N N 244 
LEU   HA   H  N N 245 
LEU   HB2  H  N N 246 
LEU   HB3  H  N N 247 
LEU   HG   H  N N 248 
LEU   HD11 H  N N 249 
LEU   HD12 H  N N 250 
LEU   HD13 H  N N 251 
LEU   HD21 H  N N 252 
LEU   HD22 H  N N 253 
LEU   HD23 H  N N 254 
LEU   HXT  H  N N 255 
LYS   N    N  N N 256 
LYS   CA   C  N S 257 
LYS   C    C  N N 258 
LYS   O    O  N N 259 
LYS   CB   C  N N 260 
LYS   CG   C  N N 261 
LYS   CD   C  N N 262 
LYS   CE   C  N N 263 
LYS   NZ   N  N N 264 
LYS   OXT  O  N N 265 
LYS   H    H  N N 266 
LYS   H2   H  N N 267 
LYS   HA   H  N N 268 
LYS   HB2  H  N N 269 
LYS   HB3  H  N N 270 
LYS   HG2  H  N N 271 
LYS   HG3  H  N N 272 
LYS   HD2  H  N N 273 
LYS   HD3  H  N N 274 
LYS   HE2  H  N N 275 
LYS   HE3  H  N N 276 
LYS   HZ1  H  N N 277 
LYS   HZ2  H  N N 278 
LYS   HZ3  H  N N 279 
LYS   HXT  H  N N 280 
MET   N    N  N N 281 
MET   CA   C  N S 282 
MET   C    C  N N 283 
MET   O    O  N N 284 
MET   CB   C  N N 285 
MET   CG   C  N N 286 
MET   SD   S  N N 287 
MET   CE   C  N N 288 
MET   OXT  O  N N 289 
MET   H    H  N N 290 
MET   H2   H  N N 291 
MET   HA   H  N N 292 
MET   HB2  H  N N 293 
MET   HB3  H  N N 294 
MET   HG2  H  N N 295 
MET   HG3  H  N N 296 
MET   HE1  H  N N 297 
MET   HE2  H  N N 298 
MET   HE3  H  N N 299 
MET   HXT  H  N N 300 
PHE   N    N  N N 301 
PHE   CA   C  N S 302 
PHE   C    C  N N 303 
PHE   O    O  N N 304 
PHE   CB   C  N N 305 
PHE   CG   C  Y N 306 
PHE   CD1  C  Y N 307 
PHE   CD2  C  Y N 308 
PHE   CE1  C  Y N 309 
PHE   CE2  C  Y N 310 
PHE   CZ   C  Y N 311 
PHE   OXT  O  N N 312 
PHE   H    H  N N 313 
PHE   H2   H  N N 314 
PHE   HA   H  N N 315 
PHE   HB2  H  N N 316 
PHE   HB3  H  N N 317 
PHE   HD1  H  N N 318 
PHE   HD2  H  N N 319 
PHE   HE1  H  N N 320 
PHE   HE2  H  N N 321 
PHE   HZ   H  N N 322 
PHE   HXT  H  N N 323 
PRO   N    N  N N 324 
PRO   CA   C  N S 325 
PRO   C    C  N N 326 
PRO   O    O  N N 327 
PRO   CB   C  N N 328 
PRO   CG   C  N N 329 
PRO   CD   C  N N 330 
PRO   OXT  O  N N 331 
PRO   H    H  N N 332 
PRO   HA   H  N N 333 
PRO   HB2  H  N N 334 
PRO   HB3  H  N N 335 
PRO   HG2  H  N N 336 
PRO   HG3  H  N N 337 
PRO   HD2  H  N N 338 
PRO   HD3  H  N N 339 
PRO   HXT  H  N N 340 
SER   N    N  N N 341 
SER   CA   C  N S 342 
SER   C    C  N N 343 
SER   O    O  N N 344 
SER   CB   C  N N 345 
SER   OG   O  N N 346 
SER   OXT  O  N N 347 
SER   H    H  N N 348 
SER   H2   H  N N 349 
SER   HA   H  N N 350 
SER   HB2  H  N N 351 
SER   HB3  H  N N 352 
SER   HG   H  N N 353 
SER   HXT  H  N N 354 
SO4   S    S  N N 355 
SO4   O1   O  N N 356 
SO4   O2   O  N N 357 
SO4   O3   O  N N 358 
SO4   O4   O  N N 359 
THR   N    N  N N 360 
THR   CA   C  N S 361 
THR   C    C  N N 362 
THR   O    O  N N 363 
THR   CB   C  N R 364 
THR   OG1  O  N N 365 
THR   CG2  C  N N 366 
THR   OXT  O  N N 367 
THR   H    H  N N 368 
THR   H2   H  N N 369 
THR   HA   H  N N 370 
THR   HB   H  N N 371 
THR   HG1  H  N N 372 
THR   HG21 H  N N 373 
THR   HG22 H  N N 374 
THR   HG23 H  N N 375 
THR   HXT  H  N N 376 
TRP   N    N  N N 377 
TRP   CA   C  N S 378 
TRP   C    C  N N 379 
TRP   O    O  N N 380 
TRP   CB   C  N N 381 
TRP   CG   C  Y N 382 
TRP   CD1  C  Y N 383 
TRP   CD2  C  Y N 384 
TRP   NE1  N  Y N 385 
TRP   CE2  C  Y N 386 
TRP   CE3  C  Y N 387 
TRP   CZ2  C  Y N 388 
TRP   CZ3  C  Y N 389 
TRP   CH2  C  Y N 390 
TRP   OXT  O  N N 391 
TRP   H    H  N N 392 
TRP   H2   H  N N 393 
TRP   HA   H  N N 394 
TRP   HB2  H  N N 395 
TRP   HB3  H  N N 396 
TRP   HD1  H  N N 397 
TRP   HE1  H  N N 398 
TRP   HE3  H  N N 399 
TRP   HZ2  H  N N 400 
TRP   HZ3  H  N N 401 
TRP   HH2  H  N N 402 
TRP   HXT  H  N N 403 
TYR   N    N  N N 404 
TYR   CA   C  N S 405 
TYR   C    C  N N 406 
TYR   O    O  N N 407 
TYR   CB   C  N N 408 
TYR   CG   C  Y N 409 
TYR   CD1  C  Y N 410 
TYR   CD2  C  Y N 411 
TYR   CE1  C  Y N 412 
TYR   CE2  C  Y N 413 
TYR   CZ   C  Y N 414 
TYR   OH   O  N N 415 
TYR   OXT  O  N N 416 
TYR   H    H  N N 417 
TYR   H2   H  N N 418 
TYR   HA   H  N N 419 
TYR   HB2  H  N N 420 
TYR   HB3  H  N N 421 
TYR   HD1  H  N N 422 
TYR   HD2  H  N N 423 
TYR   HE1  H  N N 424 
TYR   HE2  H  N N 425 
TYR   HH   H  N N 426 
TYR   HXT  H  N N 427 
VAL   N    N  N N 428 
VAL   CA   C  N S 429 
VAL   C    C  N N 430 
VAL   O    O  N N 431 
VAL   CB   C  N N 432 
VAL   CG1  C  N N 433 
VAL   CG2  C  N N 434 
VAL   OXT  O  N N 435 
VAL   H    H  N N 436 
VAL   H2   H  N N 437 
VAL   HA   H  N N 438 
VAL   HB   H  N N 439 
VAL   HG11 H  N N 440 
VAL   HG12 H  N N 441 
VAL   HG13 H  N N 442 
VAL   HG21 H  N N 443 
VAL   HG22 H  N N 444 
VAL   HG23 H  N N 445 
VAL   HXT  H  N N 446 
ZN    ZN   ZN N N 447 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1H44 C01 C02  doub Y N 1   
A1H44 C01 C06  sing Y N 2   
A1H44 C02 C03  sing Y N 3   
A1H44 C03 C04  doub Y N 4   
A1H44 C04 C05  sing Y N 5   
A1H44 C05 C06  doub Y N 6   
A1H44 N07 C08  doub N N 7   
A1H44 C08 N09  sing N N 8   
A1H44 N09 C10  sing N N 9   
A1H44 C05 N07  sing N N 10  
A1H44 C06 C10  sing N N 11  
A1H44 C08 C11  sing N N 12  
A1H44 C10 O12  doub N N 13  
A1H44 C04 N13  sing N N 14  
A1H44 C14 C15  doub Y N 15  
A1H44 C15 C16  sing Y N 16  
A1H44 C16 C17  doub Y N 17  
A1H44 C17 C18  sing Y N 18  
A1H44 C11 C14  sing Y N 19  
A1H44 C11 C18  doub Y N 20  
A1H44 C16 C19  sing N N 21  
A1H44 C19 C20  sing N N 22  
A1H44 C19 C21  sing N N 23  
A1H44 C19 C22  sing N N 24  
A1H44 N13 C23  sing N N 25  
A1H44 C23 O24  doub N N 26  
A1H44 C25 C23  sing N N 27  
A1H44 C25 C26  sing N N 28  
A1H44 C26 O27  sing N N 29  
A1H44 C25 O28  sing N N 30  
A1H44 C14 H141 sing N N 31  
A1H44 C15 H151 sing N N 32  
A1H44 C17 H171 sing N N 33  
A1H44 C20 H202 sing N N 34  
A1H44 C20 H201 sing N N 35  
A1H44 C20 H203 sing N N 36  
A1H44 C21 H211 sing N N 37  
A1H44 C21 H212 sing N N 38  
A1H44 C21 H213 sing N N 39  
A1H44 C22 H223 sing N N 40  
A1H44 C22 H222 sing N N 41  
A1H44 C22 H221 sing N N 42  
A1H44 C01 H011 sing N N 43  
A1H44 C02 H021 sing N N 44  
A1H44 C03 H031 sing N N 45  
A1H44 C18 H181 sing N N 46  
A1H44 C25 H251 sing N N 47  
A1H44 C26 H261 sing N N 48  
A1H44 C26 H262 sing N N 49  
A1H44 N09 H091 sing N N 50  
A1H44 N13 H131 sing N N 51  
A1H44 O27 H271 sing N N 52  
A1H44 O28 H281 sing N N 53  
ALA   N   CA   sing N N 54  
ALA   N   H    sing N N 55  
ALA   N   H2   sing N N 56  
ALA   CA  C    sing N N 57  
ALA   CA  CB   sing N N 58  
ALA   CA  HA   sing N N 59  
ALA   C   O    doub N N 60  
ALA   C   OXT  sing N N 61  
ALA   CB  HB1  sing N N 62  
ALA   CB  HB2  sing N N 63  
ALA   CB  HB3  sing N N 64  
ALA   OXT HXT  sing N N 65  
ARG   N   CA   sing N N 66  
ARG   N   H    sing N N 67  
ARG   N   H2   sing N N 68  
ARG   CA  C    sing N N 69  
ARG   CA  CB   sing N N 70  
ARG   CA  HA   sing N N 71  
ARG   C   O    doub N N 72  
ARG   C   OXT  sing N N 73  
ARG   CB  CG   sing N N 74  
ARG   CB  HB2  sing N N 75  
ARG   CB  HB3  sing N N 76  
ARG   CG  CD   sing N N 77  
ARG   CG  HG2  sing N N 78  
ARG   CG  HG3  sing N N 79  
ARG   CD  NE   sing N N 80  
ARG   CD  HD2  sing N N 81  
ARG   CD  HD3  sing N N 82  
ARG   NE  CZ   sing N N 83  
ARG   NE  HE   sing N N 84  
ARG   CZ  NH1  sing N N 85  
ARG   CZ  NH2  doub N N 86  
ARG   NH1 HH11 sing N N 87  
ARG   NH1 HH12 sing N N 88  
ARG   NH2 HH21 sing N N 89  
ARG   NH2 HH22 sing N N 90  
ARG   OXT HXT  sing N N 91  
ASN   N   CA   sing N N 92  
ASN   N   H    sing N N 93  
ASN   N   H2   sing N N 94  
ASN   CA  C    sing N N 95  
ASN   CA  CB   sing N N 96  
ASN   CA  HA   sing N N 97  
ASN   C   O    doub N N 98  
ASN   C   OXT  sing N N 99  
ASN   CB  CG   sing N N 100 
ASN   CB  HB2  sing N N 101 
ASN   CB  HB3  sing N N 102 
ASN   CG  OD1  doub N N 103 
ASN   CG  ND2  sing N N 104 
ASN   ND2 HD21 sing N N 105 
ASN   ND2 HD22 sing N N 106 
ASN   OXT HXT  sing N N 107 
ASP   N   CA   sing N N 108 
ASP   N   H    sing N N 109 
ASP   N   H2   sing N N 110 
ASP   CA  C    sing N N 111 
ASP   CA  CB   sing N N 112 
ASP   CA  HA   sing N N 113 
ASP   C   O    doub N N 114 
ASP   C   OXT  sing N N 115 
ASP   CB  CG   sing N N 116 
ASP   CB  HB2  sing N N 117 
ASP   CB  HB3  sing N N 118 
ASP   CG  OD1  doub N N 119 
ASP   CG  OD2  sing N N 120 
ASP   OD2 HD2  sing N N 121 
ASP   OXT HXT  sing N N 122 
CYS   N   CA   sing N N 123 
CYS   N   H    sing N N 124 
CYS   N   H2   sing N N 125 
CYS   CA  C    sing N N 126 
CYS   CA  CB   sing N N 127 
CYS   CA  HA   sing N N 128 
CYS   C   O    doub N N 129 
CYS   C   OXT  sing N N 130 
CYS   CB  SG   sing N N 131 
CYS   CB  HB2  sing N N 132 
CYS   CB  HB3  sing N N 133 
CYS   SG  HG   sing N N 134 
CYS   OXT HXT  sing N N 135 
GLN   N   CA   sing N N 136 
GLN   N   H    sing N N 137 
GLN   N   H2   sing N N 138 
GLN   CA  C    sing N N 139 
GLN   CA  CB   sing N N 140 
GLN   CA  HA   sing N N 141 
GLN   C   O    doub N N 142 
GLN   C   OXT  sing N N 143 
GLN   CB  CG   sing N N 144 
GLN   CB  HB2  sing N N 145 
GLN   CB  HB3  sing N N 146 
GLN   CG  CD   sing N N 147 
GLN   CG  HG2  sing N N 148 
GLN   CG  HG3  sing N N 149 
GLN   CD  OE1  doub N N 150 
GLN   CD  NE2  sing N N 151 
GLN   NE2 HE21 sing N N 152 
GLN   NE2 HE22 sing N N 153 
GLN   OXT HXT  sing N N 154 
GLU   N   CA   sing N N 155 
GLU   N   H    sing N N 156 
GLU   N   H2   sing N N 157 
GLU   CA  C    sing N N 158 
GLU   CA  CB   sing N N 159 
GLU   CA  HA   sing N N 160 
GLU   C   O    doub N N 161 
GLU   C   OXT  sing N N 162 
GLU   CB  CG   sing N N 163 
GLU   CB  HB2  sing N N 164 
GLU   CB  HB3  sing N N 165 
GLU   CG  CD   sing N N 166 
GLU   CG  HG2  sing N N 167 
GLU   CG  HG3  sing N N 168 
GLU   CD  OE1  doub N N 169 
GLU   CD  OE2  sing N N 170 
GLU   OE2 HE2  sing N N 171 
GLU   OXT HXT  sing N N 172 
GLY   N   CA   sing N N 173 
GLY   N   H    sing N N 174 
GLY   N   H2   sing N N 175 
GLY   CA  C    sing N N 176 
GLY   CA  HA2  sing N N 177 
GLY   CA  HA3  sing N N 178 
GLY   C   O    doub N N 179 
GLY   C   OXT  sing N N 180 
GLY   OXT HXT  sing N N 181 
HIS   N   CA   sing N N 182 
HIS   N   H    sing N N 183 
HIS   N   H2   sing N N 184 
HIS   CA  C    sing N N 185 
HIS   CA  CB   sing N N 186 
HIS   CA  HA   sing N N 187 
HIS   C   O    doub N N 188 
HIS   C   OXT  sing N N 189 
HIS   CB  CG   sing N N 190 
HIS   CB  HB2  sing N N 191 
HIS   CB  HB3  sing N N 192 
HIS   CG  ND1  sing Y N 193 
HIS   CG  CD2  doub Y N 194 
HIS   ND1 CE1  doub Y N 195 
HIS   ND1 HD1  sing N N 196 
HIS   CD2 NE2  sing Y N 197 
HIS   CD2 HD2  sing N N 198 
HIS   CE1 NE2  sing Y N 199 
HIS   CE1 HE1  sing N N 200 
HIS   NE2 HE2  sing N N 201 
HIS   OXT HXT  sing N N 202 
HOH   O   H1   sing N N 203 
HOH   O   H2   sing N N 204 
ILE   N   CA   sing N N 205 
ILE   N   H    sing N N 206 
ILE   N   H2   sing N N 207 
ILE   CA  C    sing N N 208 
ILE   CA  CB   sing N N 209 
ILE   CA  HA   sing N N 210 
ILE   C   O    doub N N 211 
ILE   C   OXT  sing N N 212 
ILE   CB  CG1  sing N N 213 
ILE   CB  CG2  sing N N 214 
ILE   CB  HB   sing N N 215 
ILE   CG1 CD1  sing N N 216 
ILE   CG1 HG12 sing N N 217 
ILE   CG1 HG13 sing N N 218 
ILE   CG2 HG21 sing N N 219 
ILE   CG2 HG22 sing N N 220 
ILE   CG2 HG23 sing N N 221 
ILE   CD1 HD11 sing N N 222 
ILE   CD1 HD12 sing N N 223 
ILE   CD1 HD13 sing N N 224 
ILE   OXT HXT  sing N N 225 
LEU   N   CA   sing N N 226 
LEU   N   H    sing N N 227 
LEU   N   H2   sing N N 228 
LEU   CA  C    sing N N 229 
LEU   CA  CB   sing N N 230 
LEU   CA  HA   sing N N 231 
LEU   C   O    doub N N 232 
LEU   C   OXT  sing N N 233 
LEU   CB  CG   sing N N 234 
LEU   CB  HB2  sing N N 235 
LEU   CB  HB3  sing N N 236 
LEU   CG  CD1  sing N N 237 
LEU   CG  CD2  sing N N 238 
LEU   CG  HG   sing N N 239 
LEU   CD1 HD11 sing N N 240 
LEU   CD1 HD12 sing N N 241 
LEU   CD1 HD13 sing N N 242 
LEU   CD2 HD21 sing N N 243 
LEU   CD2 HD22 sing N N 244 
LEU   CD2 HD23 sing N N 245 
LEU   OXT HXT  sing N N 246 
LYS   N   CA   sing N N 247 
LYS   N   H    sing N N 248 
LYS   N   H2   sing N N 249 
LYS   CA  C    sing N N 250 
LYS   CA  CB   sing N N 251 
LYS   CA  HA   sing N N 252 
LYS   C   O    doub N N 253 
LYS   C   OXT  sing N N 254 
LYS   CB  CG   sing N N 255 
LYS   CB  HB2  sing N N 256 
LYS   CB  HB3  sing N N 257 
LYS   CG  CD   sing N N 258 
LYS   CG  HG2  sing N N 259 
LYS   CG  HG3  sing N N 260 
LYS   CD  CE   sing N N 261 
LYS   CD  HD2  sing N N 262 
LYS   CD  HD3  sing N N 263 
LYS   CE  NZ   sing N N 264 
LYS   CE  HE2  sing N N 265 
LYS   CE  HE3  sing N N 266 
LYS   NZ  HZ1  sing N N 267 
LYS   NZ  HZ2  sing N N 268 
LYS   NZ  HZ3  sing N N 269 
LYS   OXT HXT  sing N N 270 
MET   N   CA   sing N N 271 
MET   N   H    sing N N 272 
MET   N   H2   sing N N 273 
MET   CA  C    sing N N 274 
MET   CA  CB   sing N N 275 
MET   CA  HA   sing N N 276 
MET   C   O    doub N N 277 
MET   C   OXT  sing N N 278 
MET   CB  CG   sing N N 279 
MET   CB  HB2  sing N N 280 
MET   CB  HB3  sing N N 281 
MET   CG  SD   sing N N 282 
MET   CG  HG2  sing N N 283 
MET   CG  HG3  sing N N 284 
MET   SD  CE   sing N N 285 
MET   CE  HE1  sing N N 286 
MET   CE  HE2  sing N N 287 
MET   CE  HE3  sing N N 288 
MET   OXT HXT  sing N N 289 
PHE   N   CA   sing N N 290 
PHE   N   H    sing N N 291 
PHE   N   H2   sing N N 292 
PHE   CA  C    sing N N 293 
PHE   CA  CB   sing N N 294 
PHE   CA  HA   sing N N 295 
PHE   C   O    doub N N 296 
PHE   C   OXT  sing N N 297 
PHE   CB  CG   sing N N 298 
PHE   CB  HB2  sing N N 299 
PHE   CB  HB3  sing N N 300 
PHE   CG  CD1  doub Y N 301 
PHE   CG  CD2  sing Y N 302 
PHE   CD1 CE1  sing Y N 303 
PHE   CD1 HD1  sing N N 304 
PHE   CD2 CE2  doub Y N 305 
PHE   CD2 HD2  sing N N 306 
PHE   CE1 CZ   doub Y N 307 
PHE   CE1 HE1  sing N N 308 
PHE   CE2 CZ   sing Y N 309 
PHE   CE2 HE2  sing N N 310 
PHE   CZ  HZ   sing N N 311 
PHE   OXT HXT  sing N N 312 
PRO   N   CA   sing N N 313 
PRO   N   CD   sing N N 314 
PRO   N   H    sing N N 315 
PRO   CA  C    sing N N 316 
PRO   CA  CB   sing N N 317 
PRO   CA  HA   sing N N 318 
PRO   C   O    doub N N 319 
PRO   C   OXT  sing N N 320 
PRO   CB  CG   sing N N 321 
PRO   CB  HB2  sing N N 322 
PRO   CB  HB3  sing N N 323 
PRO   CG  CD   sing N N 324 
PRO   CG  HG2  sing N N 325 
PRO   CG  HG3  sing N N 326 
PRO   CD  HD2  sing N N 327 
PRO   CD  HD3  sing N N 328 
PRO   OXT HXT  sing N N 329 
SER   N   CA   sing N N 330 
SER   N   H    sing N N 331 
SER   N   H2   sing N N 332 
SER   CA  C    sing N N 333 
SER   CA  CB   sing N N 334 
SER   CA  HA   sing N N 335 
SER   C   O    doub N N 336 
SER   C   OXT  sing N N 337 
SER   CB  OG   sing N N 338 
SER   CB  HB2  sing N N 339 
SER   CB  HB3  sing N N 340 
SER   OG  HG   sing N N 341 
SER   OXT HXT  sing N N 342 
SO4   S   O1   doub N N 343 
SO4   S   O2   doub N N 344 
SO4   S   O3   sing N N 345 
SO4   S   O4   sing N N 346 
THR   N   CA   sing N N 347 
THR   N   H    sing N N 348 
THR   N   H2   sing N N 349 
THR   CA  C    sing N N 350 
THR   CA  CB   sing N N 351 
THR   CA  HA   sing N N 352 
THR   C   O    doub N N 353 
THR   C   OXT  sing N N 354 
THR   CB  OG1  sing N N 355 
THR   CB  CG2  sing N N 356 
THR   CB  HB   sing N N 357 
THR   OG1 HG1  sing N N 358 
THR   CG2 HG21 sing N N 359 
THR   CG2 HG22 sing N N 360 
THR   CG2 HG23 sing N N 361 
THR   OXT HXT  sing N N 362 
TRP   N   CA   sing N N 363 
TRP   N   H    sing N N 364 
TRP   N   H2   sing N N 365 
TRP   CA  C    sing N N 366 
TRP   CA  CB   sing N N 367 
TRP   CA  HA   sing N N 368 
TRP   C   O    doub N N 369 
TRP   C   OXT  sing N N 370 
TRP   CB  CG   sing N N 371 
TRP   CB  HB2  sing N N 372 
TRP   CB  HB3  sing N N 373 
TRP   CG  CD1  doub Y N 374 
TRP   CG  CD2  sing Y N 375 
TRP   CD1 NE1  sing Y N 376 
TRP   CD1 HD1  sing N N 377 
TRP   CD2 CE2  doub Y N 378 
TRP   CD2 CE3  sing Y N 379 
TRP   NE1 CE2  sing Y N 380 
TRP   NE1 HE1  sing N N 381 
TRP   CE2 CZ2  sing Y N 382 
TRP   CE3 CZ3  doub Y N 383 
TRP   CE3 HE3  sing N N 384 
TRP   CZ2 CH2  doub Y N 385 
TRP   CZ2 HZ2  sing N N 386 
TRP   CZ3 CH2  sing Y N 387 
TRP   CZ3 HZ3  sing N N 388 
TRP   CH2 HH2  sing N N 389 
TRP   OXT HXT  sing N N 390 
TYR   N   CA   sing N N 391 
TYR   N   H    sing N N 392 
TYR   N   H2   sing N N 393 
TYR   CA  C    sing N N 394 
TYR   CA  CB   sing N N 395 
TYR   CA  HA   sing N N 396 
TYR   C   O    doub N N 397 
TYR   C   OXT  sing N N 398 
TYR   CB  CG   sing N N 399 
TYR   CB  HB2  sing N N 400 
TYR   CB  HB3  sing N N 401 
TYR   CG  CD1  doub Y N 402 
TYR   CG  CD2  sing Y N 403 
TYR   CD1 CE1  sing Y N 404 
TYR   CD1 HD1  sing N N 405 
TYR   CD2 CE2  doub Y N 406 
TYR   CD2 HD2  sing N N 407 
TYR   CE1 CZ   doub Y N 408 
TYR   CE1 HE1  sing N N 409 
TYR   CE2 CZ   sing Y N 410 
TYR   CE2 HE2  sing N N 411 
TYR   CZ  OH   sing N N 412 
TYR   OH  HH   sing N N 413 
TYR   OXT HXT  sing N N 414 
VAL   N   CA   sing N N 415 
VAL   N   H    sing N N 416 
VAL   N   H2   sing N N 417 
VAL   CA  C    sing N N 418 
VAL   CA  CB   sing N N 419 
VAL   CA  HA   sing N N 420 
VAL   C   O    doub N N 421 
VAL   C   OXT  sing N N 422 
VAL   CB  CG1  sing N N 423 
VAL   CB  CG2  sing N N 424 
VAL   CB  HB   sing N N 425 
VAL   CG1 HG11 sing N N 426 
VAL   CG1 HG12 sing N N 427 
VAL   CG1 HG13 sing N N 428 
VAL   CG2 HG21 sing N N 429 
VAL   CG2 HG22 sing N N 430 
VAL   CG2 HG23 sing N N 431 
VAL   OXT HXT  sing N N 432 
# 
_pdbx_audit_support.funding_organization   'Jane and Aatos Erkko Foundation' 
_pdbx_audit_support.country                Finland 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   7OM1 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 41 21 2' 
_space_group.name_Hall        'P 4abw 2nw' 
_space_group.IT_number        92 
_space_group.crystal_system   tetragonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    8S4W 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.015015 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.015015 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.008293 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356  2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H  ? ? 0.51345  0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032  2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882  3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732  6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
ZN ? ? 24.64596 5.25405 ? ? 2.14387  29.76375 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N    . GLY   A 1 7   ? 1.91860   19.40318  3.97906  1.000 64.34829  ? 950  GLY   A N    1 
ATOM   2    C  CA   . GLY   A 1 7   ? 0.62206   19.42445  4.63180  1.000 76.40711  ? 950  GLY   A CA   1 
ATOM   3    C  C    . GLY   A 1 7   ? 0.03824   18.04938  4.95894  1.000 82.12015  ? 950  GLY   A C    1 
ATOM   4    O  O    . GLY   A 1 7   ? -0.90519  17.58554  4.30823  1.000 78.77958  ? 950  GLY   A O    1 
ATOM   5    H  HA2  . GLY   A 1 7   ? 0.70186   19.91590  5.46427  1.000 91.70381  ? 950  GLY   A HA2  1 
ATOM   6    H  HA3  . GLY   A 1 7   ? -0.00863  19.88208  4.05413  1.000 91.70381  ? 950  GLY   A HA3  1 
ATOM   7    N  N    . SER   A 1 8   ? 0.59888   17.40077  5.99328  1.000 84.89554  ? 951  SER   A N    1 
ATOM   8    C  CA   . SER   A 1 8   ? 0.15361   16.08995  6.47053  1.000 70.24213  ? 951  SER   A CA   1 
ATOM   9    C  C    . SER   A 1 8   ? -0.63670  16.14442  7.77035  1.000 69.15286  ? 951  SER   A C    1 
ATOM   10   O  O    . SER   A 1 8   ? -1.18829  15.11309  8.18975  1.000 67.28924  ? 951  SER   A O    1 
ATOM   11   C  CB   . SER   A 1 8   ? 1.36341   15.16322  6.69866  1.000 71.02827  ? 951  SER   A CB   1 
ATOM   12   O  OG   . SER   A 1 8   ? 2.18284   15.63094  7.77500  1.000 66.85328  ? 951  SER   A OG   1 
ATOM   13   H  H    . SER   A 1 8   ? 1.25967   17.71334  6.44632  1.000 101.88992 ? 951  SER   A H    1 
ATOM   14   H  HA   . SER   A 1 8   ? -0.41270  15.70464  5.78370  1.000 84.30583  ? 951  SER   A HA   1 
ATOM   15   H  HB2  . SER   A 1 8   ? 1.04120   14.27384  6.91331  1.000 85.24920  ? 951  SER   A HB2  1 
ATOM   16   H  HB3  . SER   A 1 8   ? 1.89545   15.13665  5.88802  1.000 85.24920  ? 951  SER   A HB3  1 
ATOM   17   H  HG   . SER   A 1 8   ? 2.48138   16.39575  7.59742  1.000 80.23921  ? 951  SER   A HG   1 
ATOM   18   N  N    . GLY   A 1 9   ? -0.70116  17.30734  8.41719  1.000 58.24590  ? 952  GLY   A N    1 
ATOM   19   C  CA   . GLY   A 1 9   ? -1.22945  17.43551  9.75107  1.000 57.99353  ? 952  GLY   A CA   1 
ATOM   20   C  C    . GLY   A 1 9   ? -0.19343  17.30531  10.84570 1.000 53.61414  ? 952  GLY   A C    1 
ATOM   21   O  O    . GLY   A 1 9   ? -0.50555  17.58350  12.00773 1.000 53.06438  ? 952  GLY   A O    1 
ATOM   22   H  H    . GLY   A 1 9   ? -0.43386  18.05409  8.08473  1.000 69.91036  ? 952  GLY   A H    1 
ATOM   23   H  HA2  . GLY   A 1 9   ? -1.64880  18.30573  9.83920  1.000 69.60751  ? 952  GLY   A HA2  1 
ATOM   24   H  HA3  . GLY   A 1 9   ? -1.89846  16.74703  9.89009  1.000 69.60751  ? 952  GLY   A HA3  1 
ATOM   25   N  N    . THR   A 1 10  ? 1.02970   16.89611  10.51386 1.000 51.27422  ? 953  THR   A N    1 
ATOM   26   C  CA   . THR   A 1 10  ? 2.03518   16.59724  11.52313 1.000 53.76254  ? 953  THR   A CA   1 
ATOM   27   C  C    . THR   A 1 10  ? 2.90599   17.82081  11.77468 1.000 49.64985  ? 953  THR   A C    1 
ATOM   28   O  O    . THR   A 1 10  ? 3.46780   18.40160  10.83751 1.000 40.76820  ? 953  THR   A O    1 
ATOM   29   C  CB   . THR   A 1 10  ? 2.91534   15.41815  11.09378 1.000 50.86733  ? 953  THR   A CB   1 
ATOM   30   O  OG1  . THR   A 1 10  ? 2.17747   14.19418  11.19603 1.000 46.28316  ? 953  THR   A OG1  1 
ATOM   31   C  CG2  . THR   A 1 10  ? 4.12732   15.32443  11.96643 1.000 40.43328  ? 953  THR   A CG2  1 
ATOM   32   H  H    . THR   A 1 10  ? 1.30010   16.78414  9.70519  1.000 61.54434  ? 953  THR   A H    1 
ATOM   33   H  HA   . THR   A 1 10  ? 1.58444   16.36001  12.34863 1.000 64.53033  ? 953  THR   A HA   1 
ATOM   34   H  HB   . THR   A 1 10  ? 3.19808   15.55147  10.17553 1.000 61.05608  ? 953  THR   A HB   1 
ATOM   35   H  HG1  . THR   A 1 10  ? 2.67953   13.54137  11.03057 1.000 55.55507  ? 953  THR   A HG1  1 
ATOM   36   H  HG21 . THR   A 1 10  ? 4.49739   14.42874  11.92516 1.000 48.53521  ? 953  THR   A HG21 1 
ATOM   37   H  HG22 . THR   A 1 10  ? 4.79993   15.95695  11.66909 1.000 48.53521  ? 953  THR   A HG22 1 
ATOM   38   H  HG23 . THR   A 1 10  ? 3.89075   15.52525  12.88545 1.000 48.53521  ? 953  THR   A HG23 1 
ATOM   39   N  N    . ILE   A 1 11  ? 3.01898   18.20725  13.03820 1.000 44.48280  ? 954  ILE   A N    1 
ATOM   40   C  CA   . ILE   A 1 11  ? 4.04898   19.15585  13.41900 1.000 49.38619  ? 954  ILE   A CA   1 
ATOM   41   C  C    . ILE   A 1 11  ? 4.99005   18.44663  14.38254 1.000 47.41560  ? 954  ILE   A C    1 
ATOM   42   O  O    . ILE   A 1 11  ? 4.58785   17.52382  15.09735 1.000 42.49433  ? 954  ILE   A O    1 
ATOM   43   C  CB   . ILE   A 1 11  ? 3.49789   20.46176  14.03429 1.000 49.52874  ? 954  ILE   A CB   1 
ATOM   44   C  CG1  . ILE   A 1 11  ? 2.98998   20.26780  15.44903 1.000 61.17157  ? 954  ILE   A CG1  1 
ATOM   45   C  CG2  . ILE   A 1 11  ? 2.37266   21.05776  13.16968 1.000 51.62437  ? 954  ILE   A CG2  1 
ATOM   46   C  CD1  . ILE   A 1 11  ? 2.77964   21.61044  16.16541 1.000 68.27887  ? 954  ILE   A CD1  1 
ATOM   47   H  H    . ILE   A 1 11  ? 2.51684   17.93644  13.68172 1.000 53.39464  ? 954  ILE   A H    1 
ATOM   48   H  HA   . ILE   A 1 11  ? 4.53911   19.42054  12.62489 1.000 59.27870  ? 954  ILE   A HA   1 
ATOM   49   H  HB   . ILE   A 1 11  ? 4.24761   21.07663  14.06191 1.000 59.44977  ? 954  ILE   A HB   1 
ATOM   50   H  HG12 . ILE   A 1 11  ? 2.14066   19.79996  15.42269 1.000 73.42116  ? 954  ILE   A HG12 1 
ATOM   51   H  HG13 . ILE   A 1 11  ? 3.63776   19.75127  15.95350 1.000 73.42116  ? 954  ILE   A HG13 1 
ATOM   52   H  HG21 . ILE   A 1 11  ? 2.15504   21.94307  13.50100 1.000 61.96452  ? 954  ILE   A HG21 1 
ATOM   53   H  HG22 . ILE   A 1 11  ? 2.67696   21.11418  12.25038 1.000 61.96452  ? 954  ILE   A HG22 1 
ATOM   54   H  HG23 . ILE   A 1 11  ? 1.59336   20.48289  13.22546 1.000 61.96452  ? 954  ILE   A HG23 1 
ATOM   55   H  HD11 . ILE   A 1 11  ? 2.60827   21.44339  17.10543 1.000 81.94992  ? 954  ILE   A HD11 1 
ATOM   56   H  HD12 . ILE   A 1 11  ? 3.57941   22.15021  16.06582 1.000 81.94992  ? 954  ILE   A HD12 1 
ATOM   57   H  HD13 . ILE   A 1 11  ? 2.02154   22.06572  15.76678 1.000 81.94992  ? 954  ILE   A HD13 1 
ATOM   58   N  N    . LEU   A 1 12  ? 6.26245   18.87313  14.35315 1.000 43.44564  ? 955  LEU   A N    1 
ATOM   59   C  CA   . LEU   A 1 12  ? 7.32069   18.38154  15.22486 1.000 41.13573  ? 955  LEU   A CA   1 
ATOM   60   C  C    . LEU   A 1 12  ? 7.73803   19.50010  16.16687 1.000 46.19407  ? 955  LEU   A C    1 
ATOM   61   O  O    . LEU   A 1 12  ? 8.39609   20.46212  15.74230 1.000 42.65294  ? 955  LEU   A O    1 
ATOM   62   C  CB   . LEU   A 1 12  ? 8.53407   17.92404  14.42420 1.000 46.41002  ? 955  LEU   A CB   1 
ATOM   63   C  CG   . LEU   A 1 12  ? 8.34946   16.82804  13.38177 1.000 51.03389  ? 955  LEU   A CG   1 
ATOM   64   C  CD1  . LEU   A 1 12  ? 9.63652   16.63533  12.60839 1.000 47.85358  ? 955  LEU   A CD1  1 
ATOM   65   C  CD2  . LEU   A 1 12  ? 7.92998   15.54030  14.05037 1.000 45.38044  ? 955  LEU   A CD2  1 
ATOM   66   H  H    . LEU   A 1 12  ? 6.54182   19.47614  13.80732 1.000 52.15004  ? 955  LEU   A H    1 
ATOM   67   H  HA   . LEU   A 1 12  ? 6.96846   17.63605  15.73583 1.000 49.37815  ? 955  LEU   A HA   1 
ATOM   68   H  HB2  . LEU   A 1 12  ? 8.88147   18.69737  13.95285 1.000 55.70729  ? 955  LEU   A HB2  1 
ATOM   69   H  HB3  . LEU   A 1 12  ? 9.19374   17.59621  15.05528 1.000 55.70729  ? 955  LEU   A HB3  1 
ATOM   70   H  HG   . LEU   A 1 12  ? 7.65240   17.08215  12.75692 1.000 61.25595  ? 955  LEU   A HG   1 
ATOM   71   H  HD11 . LEU   A 1 12  ? 9.51604   15.91596  11.96895 1.000 57.43957  ? 955  LEU   A HD11 1 
ATOM   72   H  HD12 . LEU   A 1 12  ? 9.85172   17.45883  12.14316 1.000 57.43957  ? 955  LEU   A HD12 1 
ATOM   73   H  HD13 . LEU   A 1 12  ? 10.34728  16.41061  13.22906 1.000 57.43957  ? 955  LEU   A HD13 1 
ATOM   74   H  HD21 . LEU   A 1 12  ? 7.85826   14.84440  13.37844 1.000 54.47181  ? 955  LEU   A HD21 1 
ATOM   75   H  HD22 . LEU   A 1 12  ? 8.59719   15.29527  14.71044 1.000 54.47181  ? 955  LEU   A HD22 1 
ATOM   76   H  HD23 . LEU   A 1 12  ? 7.07138   15.67348  14.48160 1.000 54.47181  ? 955  LEU   A HD23 1 
ATOM   77   N  N    . ILE   A 1 13  ? 7.41414   19.34434  17.44503 1.000 43.68134  ? 956  ILE   A N    1 
ATOM   78   C  CA   . ILE   A 1 13  ? 7.80830   20.30034  18.47374 1.000 40.39732  ? 956  ILE   A CA   1 
ATOM   79   C  C    . ILE   A 1 13  ? 9.15543   19.87545  19.05192 1.000 49.54370  ? 956  ILE   A C    1 
ATOM   80   O  O    . ILE   A 1 13  ? 9.28469   18.81235  19.67707 1.000 50.86663  ? 956  ILE   A O    1 
ATOM   81   C  CB   . ILE   A 1 13  ? 6.74759   20.39308  19.58122 1.000 41.94854  ? 956  ILE   A CB   1 
ATOM   82   C  CG1  . ILE   A 1 13  ? 5.35700   20.71910  19.00598 1.000 48.20579  ? 956  ILE   A CG1  1 
ATOM   83   C  CG2  . ILE   A 1 13  ? 7.17831   21.39399  20.58243 1.000 39.20813  ? 956  ILE   A CG2  1 
ATOM   84   C  CD1  . ILE   A 1 13  ? 5.26309   22.05459  18.31609 1.000 53.58250  ? 956  ILE   A CD1  1 
ATOM   85   H  H    . ILE   A 1 13  ? 6.95806   18.68092  17.74745 1.000 52.43288  ? 956  ILE   A H    1 
ATOM   86   H  HA   . ILE   A 1 13  ? 7.91254   21.17442  18.06629 1.000 48.49206  ? 956  ILE   A HA   1 
ATOM   87   H  HB   . ILE   A 1 13  ? 6.66722   19.52887  20.01431 1.000 50.35353  ? 956  ILE   A HB   1 
ATOM   88   H  HG12 . ILE   A 1 13  ? 5.12366   20.03719  18.35678 1.000 57.86222  ? 956  ILE   A HG12 1 
ATOM   89   H  HG13 . ILE   A 1 13  ? 4.71441   20.71914  19.73260 1.000 57.86222  ? 956  ILE   A HG13 1 
ATOM   90   H  HG21 . ILE   A 1 13  ? 6.41799   21.63655  21.13378 1.000 47.06503  ? 956  ILE   A HG21 1 
ATOM   91   H  HG22 . ILE   A 1 13  ? 7.87718   21.00864  21.13377 1.000 47.06503  ? 956  ILE   A HG22 1 
ATOM   92   H  HG23 . ILE   A 1 13  ? 7.51550   22.17761  20.12075 1.000 47.06503  ? 956  ILE   A HG23 1 
ATOM   93   H  HD11 . ILE   A 1 13  ? 4.34459   22.36444  18.35148 1.000 64.31427  ? 956  ILE   A HD11 1 
ATOM   94   H  HD12 . ILE   A 1 13  ? 5.84290   22.68599  18.77002 1.000 64.31427  ? 956  ILE   A HD12 1 
ATOM   95   H  HD13 . ILE   A 1 13  ? 5.54272   21.95344  17.39279 1.000 64.31427  ? 956  ILE   A HD13 1 
ATOM   96   N  N    . ASP   A 1 14  ? 10.15828  20.71223  18.85793 1.000 44.50282  ? 957  ASP   A N    1 
ATOM   97   C  CA   . ASP   A 1 14  ? 11.48063  20.46854  19.42237 1.000 43.91418  ? 957  ASP   A CA   1 
ATOM   98   C  C    . ASP   A 1 14  ? 11.48096  20.61740  20.94564 1.000 48.29689  ? 957  ASP   A C    1 
ATOM   99   O  O    . ASP   A 1 14  ? 11.00522  21.61945  21.48412 1.000 51.85600  ? 957  ASP   A O    1 
ATOM   100  C  CB   . ASP   A 1 14  ? 12.43559  21.46506  18.79092 1.000 49.71054  ? 957  ASP   A CB   1 
ATOM   101  C  CG   . ASP   A 1 14  ? 13.78667  20.91333  18.56013 1.000 60.27675  ? 957  ASP   A CG   1 
ATOM   102  O  OD1  . ASP   A 1 14  ? 14.10114  19.84922  19.12534 1.000 73.03079  ? 957  ASP   A OD1  1 
ATOM   103  O  OD2  . ASP   A 1 14  ? 14.54004  21.54979  17.79245 1.000 76.84756  ? 957  ASP   A OD2  1 
ATOM   104  H  H    . ASP   A 1 14  ? 10.10353  21.43752  18.39907 1.000 53.41867  ? 957  ASP   A H    1 
ATOM   105  H  HA   . ASP   A 1 14  ? 11.76503  19.55994  19.23676 1.000 52.71229  ? 957  ASP   A HA   1 
ATOM   106  H  HB2  . ASP   A 1 14  ? 12.07730  21.74360  17.93363 1.000 59.66792  ? 957  ASP   A HB2  1 
ATOM   107  H  HB3  . ASP   A 1 14  ? 12.52346  22.23170  19.37866 1.000 59.66792  ? 957  ASP   A HB3  1 
ATOM   108  N  N    . LEU   A 1 15  ? 12.02102  19.62409  21.65457 1.000 43.03260  ? 958  LEU   A N    1 
ATOM   109  C  CA   . LEU   A 1 15  ? 12.11997  19.71238  23.10400 1.000 41.92734  ? 958  LEU   A CA   1 
ATOM   110  C  C    . LEU   A 1 15  ? 13.49461  20.21276  23.50504 1.000 46.86354  ? 958  LEU   A C    1 
ATOM   111  O  O    . LEU   A 1 15  ? 14.50421  19.87022  22.88410 1.000 48.77214  ? 958  LEU   A O    1 
ATOM   112  C  CB   . LEU   A 1 15  ? 11.88359  18.38304  23.80483 1.000 38.21227  ? 958  LEU   A CB   1 
ATOM   113  C  CG   . LEU   A 1 15  ? 10.59241  17.64401  23.49488 1.000 43.70454  ? 958  LEU   A CG   1 
ATOM   114  C  CD1  . LEU   A 1 15  ? 10.58942  16.28026  24.14572 1.000 42.13034  ? 958  LEU   A CD1  1 
ATOM   115  C  CD2  . LEU   A 1 15  ? 9.43264   18.42958  23.99024 1.000 49.80148  ? 958  LEU   A CD2  1 
ATOM   116  H  H    . LEU   A 1 15  ? 12.33304  18.89719  21.31713 1.000 51.65439  ? 958  LEU   A H    1 
ATOM   117  H  HA   . LEU   A 1 15  ? 11.43421  20.33237  23.39768 1.000 50.32808  ? 958  LEU   A HA   1 
ATOM   118  H  HB2  . LEU   A 1 15  ? 12.61146  17.78835  23.56515 1.000 45.87000  ? 958  LEU   A HB2  1 
ATOM   119  H  HB3  . LEU   A 1 15  ? 11.89021  18.54698  24.76085 1.000 45.87000  ? 958  LEU   A HB3  1 
ATOM   120  H  HG   . LEU   A 1 15  ? 10.51745  17.52774  22.53479 1.000 52.46072  ? 958  LEU   A HG   1 
ATOM   121  H  HD11 . LEU   A 1 15  ? 9.80652   15.79044  23.84899 1.000 50.57168  ? 958  LEU   A HD11 1 
ATOM   122  H  HD12 . LEU   A 1 15  ? 11.39455  15.80513  23.88707 1.000 50.57168  ? 958  LEU   A HD12 1 
ATOM   123  H  HD13 . LEU   A 1 15  ? 10.56530  16.39020  25.10917 1.000 50.57168  ? 958  LEU   A HD13 1 
ATOM   124  H  HD21 . LEU   A 1 15  ? 8.65389   17.85258  24.02919 1.000 59.77705  ? 958  LEU   A HD21 1 
ATOM   125  H  HD22 . LEU   A 1 15  ? 9.63670   18.77000  24.87532 1.000 59.77705  ? 958  LEU   A HD22 1 
ATOM   126  H  HD23 . LEU   A 1 15  ? 9.26783   19.16705  23.38207 1.000 59.77705  ? 958  LEU   A HD23 1 
ATOM   127  N  N    . SER   A 1 16  ? 13.51642  20.98447  24.54486 1.000 51.03045  ? 959  SER   A N    1 
ATOM   128  C  CA   . SER   A 1 16  ? 14.74497  21.46014  25.14225 1.000 47.24076  ? 959  SER   A CA   1 
ATOM   129  C  C    . SER   A 1 16  ? 15.39684  20.37563  25.99313 1.000 42.23194  ? 959  SER   A C    1 
ATOM   130  O  O    . SER   A 1 16  ? 14.71374  19.61487  26.67883 1.000 42.62000  ? 959  SER   A O    1 
ATOM   131  C  CB   . SER   A 1 16  ? 14.45246  22.67359  26.01227 1.000 52.92069  ? 959  SER   A CB   1 
ATOM   132  O  OG   . SER   A 1 16  ? 15.58694  22.99169  26.80004 1.000 62.28269  ? 959  SER   A OG   1 
ATOM   133  H  H    . SER   A 1 16  ? 12.81159  21.26577  24.94943 1.000 61.25182  ? 959  SER   A H    1 
ATOM   134  H  HA   . SER   A 1 16  ? 15.37068  21.70485  24.44261 1.000 56.70419  ? 959  SER   A HA   1 
ATOM   135  H  HB2  . SER   A 1 16  ? 14.23708  23.42928  25.44356 1.000 63.52011  ? 959  SER   A HB2  1 
ATOM   136  H  HB3  . SER   A 1 16  ? 13.70427  22.47419  26.59652 1.000 63.52011  ? 959  SER   A HB3  1 
ATOM   137  H  HG   . SER   A 1 16  ? 15.44499  23.69457  27.23753 1.000 74.75451  ? 959  SER   A HG   1 
ATOM   138  N  N    . PRO   A 1 17  ? 16.72241  20.30285  25.99318 1.000 41.38446  ? 960  PRO   A N    1 
ATOM   139  C  CA   . PRO   A 1 17  ? 17.41330  19.39018  26.91478 1.000 43.57418  ? 960  PRO   A CA   1 
ATOM   140  C  C    . PRO   A 1 17  ? 17.09112  19.59496  28.37768 1.000 50.72613  ? 960  PRO   A C    1 
ATOM   141  O  O    . PRO   A 1 17  ? 17.25339  18.64481  29.15677 1.000 55.89534  ? 960  PRO   A O    1 
ATOM   142  C  CB   . PRO   A 1 17  ? 18.89001  19.68115  26.64223 1.000 39.19578  ? 960  PRO   A CB   1 
ATOM   143  C  CG   . PRO   A 1 17  ? 18.92716  20.08371  25.21584 1.000 40.21258  ? 960  PRO   A CG   1 
ATOM   144  C  CD   . PRO   A 1 17  ? 17.60720  20.80615  24.93672 1.000 42.88553  ? 960  PRO   A CD   1 
ATOM   145  H  HA   . PRO   A 1 17  ? 17.19720  18.47576  26.67389 1.000 52.30430  ? 960  PRO   A HA   1 
ATOM   146  H  HB2  . PRO   A 1 17  ? 19.19931  20.39924  27.21633 1.000 47.05022  ? 960  PRO   A HB2  1 
ATOM   147  H  HB3  . PRO   A 1 17  ? 19.42013  18.88317  26.79422 1.000 47.05022  ? 960  PRO   A HB3  1 
ATOM   148  H  HG2  . PRO   A 1 17  ? 19.67972  20.67683  25.06503 1.000 48.27037  ? 960  PRO   A HG2  1 
ATOM   149  H  HG3  . PRO   A 1 17  ? 19.00946  19.29477  24.65753 1.000 48.27037  ? 960  PRO   A HG3  1 
ATOM   150  H  HD2  . PRO   A 1 17  ? 17.71743  21.76733  25.00660 1.000 51.47792  ? 960  PRO   A HD2  1 
ATOM   151  H  HD3  . PRO   A 1 17  ? 17.26484  20.57440  24.05924 1.000 51.47792  ? 960  PRO   A HD3  1 
ATOM   152  N  N    . ASP   A 1 18  ? 16.66208  20.79529  28.78883 1.000 49.61336  ? 961  ASP   A N    1 
ATOM   153  C  CA   . ASP   A 1 18  ? 16.21908  21.03980  30.15898 1.000 48.10627  ? 961  ASP   A CA   1 
ATOM   154  C  C    . ASP   A 1 18  ? 14.84057  20.47355  30.47229 1.000 46.31820  ? 961  ASP   A C    1 
ATOM   155  O  O    . ASP   A 1 18  ? 14.44874  20.47950  31.63256 1.000 51.21972  ? 961  ASP   A O    1 
ATOM   156  C  CB   . ASP   A 1 18  ? 16.15864  22.53922  30.45828 1.000 55.41747  ? 961  ASP   A CB   1 
ATOM   157  C  CG   . ASP   A 1 18  ? 17.45348  23.24133  30.15952 1.000 75.86589  ? 961  ASP   A CG   1 
ATOM   158  O  OD1  . ASP   A 1 18  ? 18.53474  22.60461  30.31504 1.000 77.23854  ? 961  ASP   A OD1  1 
ATOM   159  O  OD2  . ASP   A 1 18  ? 17.38127  24.43533  29.76753 1.000 77.09174  ? 961  ASP   A OD2  1 
ATOM   160  H  H    . ASP   A 1 18  ? 16.61905  21.49020  28.28401 1.000 59.55131  ? 961  ASP   A H    1 
ATOM   161  H  HA   . ASP   A 1 18  ? 16.87674  20.62083  30.73592 1.000 57.74280  ? 961  ASP   A HA   1 
ATOM   162  H  HB2  . ASP   A 1 18  ? 15.46518  22.94310  29.91340 1.000 66.51623  ? 961  ASP   A HB2  1 
ATOM   163  H  HB3  . ASP   A 1 18  ? 15.95788  22.66648  31.39871 1.000 66.51623  ? 961  ASP   A HB3  1 
ATOM   164  N  N    . ASP   A 1 19  ? 14.09305  20.01679  29.47573 1.000 46.44438  ? 962  ASP   A N    1 
ATOM   165  C  CA   . ASP   A 1 19  ? 12.72019  19.57606  29.68601 1.000 52.35837  ? 962  ASP   A CA   1 
ATOM   166  C  C    . ASP   A 1 19  ? 12.66179  18.21600  30.38106 1.000 50.05054  ? 962  ASP   A C    1 
ATOM   167  O  O    . ASP   A 1 19  ? 13.37059  17.28407  30.00691 1.000 49.70525  ? 962  ASP   A O    1 
ATOM   168  C  CB   . ASP   A 1 19  ? 12.02999  19.51786  28.32644 1.000 50.07729  ? 962  ASP   A CB   1 
ATOM   169  C  CG   . ASP   A 1 19  ? 10.54033  19.37250  28.43142 1.000 56.10086  ? 962  ASP   A CG   1 
ATOM   170  O  OD1  . ASP   A 1 19  ? 10.07426  18.72661  29.39667 1.000 61.89827  ? 962  ASP   A OD1  1 
ATOM   171  O  OD2  . ASP   A 1 19  ? 9.84459   19.90645  27.53527 1.000 51.07022  ? 962  ASP   A OD2  1 
ATOM   172  H  H    . ASP   A 1 19  ? 14.35878  19.95097  28.66046 1.000 55.74853  ? 962  ASP   A H    1 
ATOM   173  H  HA   . ASP   A 1 19  ? 12.25672  20.19875  30.26769 1.000 62.84532  ? 962  ASP   A HA   1 
ATOM   174  H  HB2  . ASP   A 1 19  ? 12.21705  20.33750  27.84260 1.000 60.10803  ? 962  ASP   A HB2  1 
ATOM   175  H  HB3  . ASP   A 1 19  ? 12.37066  18.75582  27.83233 1.000 60.10803  ? 962  ASP   A HB3  1 
ATOM   176  N  N    . LYS   A 1 20  ? 11.80395  18.07917  31.38599 1.000 57.24750  ? 963  LYS   A N    1 
ATOM   177  C  CA   . LYS   A 1 20  ? 11.74770  16.80275  32.09399 1.000 60.08614  ? 963  LYS   A CA   1 
ATOM   178  C  C    . LYS   A 1 20  ? 11.45679  15.67212  31.12211 1.000 57.72386  ? 963  LYS   A C    1 
ATOM   179  O  O    . LYS   A 1 20  ? 11.82643  14.51556  31.36105 1.000 58.47723  ? 963  LYS   A O    1 
ATOM   180  C  CB   . LYS   A 1 20  ? 10.66977  16.83384  33.18257 1.000 56.74097  ? 963  LYS   A CB   1 
ATOM   181  C  CG   . LYS   A 1 20  ? 9.26874   16.63113  32.59839 1.000 69.39874  ? 963  LYS   A CG   1 
ATOM   182  C  CD   . LYS   A 1 20  ? 8.15192   17.05885  33.52519 1.000 62.69651  ? 963  LYS   A CD   1 
ATOM   183  C  CE   . LYS   A 1 20  ? 6.85416   17.12896  32.76131 1.000 68.92192  ? 963  LYS   A CE   1 
ATOM   184  N  NZ   . LYS   A 1 20  ? 5.71438   17.26966  33.70909 1.000 69.03985  ? 963  LYS   A NZ   1 
ATOM   185  H  H    . LYS   A 1 20  ? 11.26322  18.68518  31.66874 1.000 68.71228  ? 963  LYS   A H    1 
ATOM   186  H  HA   . LYS   A 1 20  ? 12.60080  16.64665  32.52845 1.000 72.11864  ? 963  LYS   A HA   1 
ATOM   187  H  HB2  . LYS   A 1 20  ? 10.83954  16.12352  33.82095 1.000 68.10443  ? 963  LYS   A HB2  1 
ATOM   188  H  HB3  . LYS   A 1 20  ? 10.69193  17.69423  33.62993 1.000 68.10443  ? 963  LYS   A HB3  1 
ATOM   189  H  HG2  . LYS   A 1 20  ? 9.19167   17.15199  31.78373 1.000 83.29376  ? 963  LYS   A HG2  1 
ATOM   190  H  HG3  . LYS   A 1 20  ? 9.14519   15.68912  32.40282 1.000 83.29376  ? 963  LYS   A HG3  1 
ATOM   191  H  HD2  . LYS   A 1 20  ? 8.05683   16.41394  34.24349 1.000 75.25109  ? 963  LYS   A HD2  1 
ATOM   192  H  HD3  . LYS   A 1 20  ? 8.34683   17.93602  33.89052 1.000 75.25109  ? 963  LYS   A HD3  1 
ATOM   193  H  HE2  . LYS   A 1 20  ? 6.86405   17.89746  32.16952 1.000 82.72158  ? 963  LYS   A HE2  1 
ATOM   194  H  HE3  . LYS   A 1 20  ? 6.73307   16.31560  32.24684 1.000 82.72158  ? 963  LYS   A HE3  1 
ATOM   195  H  HZ1  . LYS   A 1 20  ? 4.96059   17.41598  33.25910 1.000 82.86310  ? 963  LYS   A HZ1  1 
ATOM   196  H  HZ2  . LYS   A 1 20  ? 5.62429   16.52583  34.18940 1.000 82.86310  ? 963  LYS   A HZ2  1 
ATOM   197  H  HZ3  . LYS   A 1 20  ? 5.85926   17.95346  34.26002 1.000 82.86310  ? 963  LYS   A HZ3  1 
ATOM   198  N  N    . GLU   A 1 21  ? 10.79840  15.99078  30.02623 1.000 55.87963  ? 964  GLU   A N    1 
ATOM   199  C  CA   . GLU   A 1 21  ? 10.25830  15.03217  29.08150 1.000 56.14080  ? 964  GLU   A CA   1 
ATOM   200  C  C    . GLU   A 1 21  ? 11.31007  14.60280  28.06373 1.000 52.91618  ? 964  GLU   A C    1 
ATOM   201  O  O    . GLU   A 1 21  ? 11.35243  13.43151  27.68890 1.000 49.33693  ? 964  GLU   A O    1 
ATOM   202  C  CB   . GLU   A 1 21  ? 9.04213   15.68444  28.44927 1.000 58.28911  ? 964  GLU   A CB   1 
ATOM   203  C  CG   . GLU   A 1 21  ? 8.28115   14.90342  27.50691 1.000 54.37291  ? 964  GLU   A CG   1 
ATOM   204  C  CD   . GLU   A 1 21  ? 6.90157   15.51491  27.31776 1.000 59.27428  ? 964  GLU   A CD   1 
ATOM   205  O  OE1  . GLU   A 1 21  ? 6.23452   15.82779  28.33913 1.000 80.74764  ? 964  GLU   A OE1  1 
ATOM   206  O  OE2  . GLU   A 1 21  ? 6.48621   15.68417  26.15748 1.000 52.56512  ? 964  GLU   A OE2  1 
ATOM   207  H  H    . GLU   A 1 21  ? 10.64074  16.80294  29.79140 1.000 67.07083  ? 964  GLU   A H    1 
ATOM   208  H  HA   . GLU   A 1 21  ? 9.96547   14.20943  29.50371 1.000 67.38424  ? 964  GLU   A HA   1 
ATOM   209  H  HB2  . GLU   A 1 21  ? 8.43369   15.93269  29.16276 1.000 69.96221  ? 964  GLU   A HB2  1 
ATOM   210  H  HB3  . GLU   A 1 21  ? 9.34183   16.47747  27.97790 1.000 69.96221  ? 964  GLU   A HB3  1 
ATOM   211  H  HG2  . GLU   A 1 21  ? 8.73630   14.89081  26.65041 1.000 65.26277  ? 964  GLU   A HG2  1 
ATOM   212  H  HG3  . GLU   A 1 21  ? 8.17764   13.99866  27.84095 1.000 65.26277  ? 964  GLU   A HG3  1 
ATOM   213  N  N    . PHE   A 1 22  ? 12.17770  15.53523  27.64827 1.000 48.04955  ? 965  PHE   A N    1 
ATOM   214  C  CA   . PHE   A 1 22  ? 13.40521  15.21293  26.91111 1.000 41.52488  ? 965  PHE   A CA   1 
ATOM   215  C  C    . PHE   A 1 22  ? 14.28877  14.26983  27.70299 1.000 44.93172  ? 965  PHE   A C    1 
ATOM   216  O  O    . PHE   A 1 22  ? 14.85244  13.31345  27.15158 1.000 45.55284  ? 965  PHE   A O    1 
ATOM   217  C  CB   . PHE   A 1 22  ? 14.17410  16.51314  26.60636 1.000 42.89318  ? 965  PHE   A CB   1 
ATOM   218  C  CG   . PHE   A 1 22  ? 15.47238  16.32759  25.87486 1.000 40.80082  ? 965  PHE   A CG   1 
ATOM   219  C  CD1  . PHE   A 1 22  ? 16.58314  15.78122  26.49924 1.000 37.26687  ? 965  PHE   A CD1  1 
ATOM   220  C  CD2  . PHE   A 1 22  ? 15.59951  16.75529  24.57085 1.000 37.04245  ? 965  PHE   A CD2  1 
ATOM   221  C  CE1  . PHE   A 1 22  ? 17.77066  15.61517  25.82449 1.000 29.43192  ? 965  PHE   A CE1  1 
ATOM   222  C  CE2  . PHE   A 1 22  ? 16.79721  16.62089  23.91237 1.000 39.52812  ? 965  PHE   A CE2  1 
ATOM   223  C  CZ   . PHE   A 1 22  ? 17.88105  16.04079  24.54427 1.000 34.39396  ? 965  PHE   A CZ   1 
ATOM   224  H  H    . PHE   A 1 22  ? 12.07727  16.37866  27.78293 1.000 57.67473  ? 965  PHE   A H    1 
ATOM   225  H  HA   . PHE   A 1 22  ? 13.16770  14.78085  26.07577 1.000 49.84513  ? 965  PHE   A HA   1 
ATOM   226  H  HB2  . PHE   A 1 22  ? 13.61061  17.08161  26.05844 1.000 51.48709  ? 965  PHE   A HB2  1 
ATOM   227  H  HB3  . PHE   A 1 22  ? 14.37446  16.95517  27.44622 1.000 51.48709  ? 965  PHE   A HB3  1 
ATOM   228  H  HD1  . PHE   A 1 22  ? 16.52447  15.52221  27.39051 1.000 44.73553  ? 965  PHE   A HD1  1 
ATOM   229  H  HD2  . PHE   A 1 22  ? 14.87154  17.13631  24.13521 1.000 44.46621  ? 965  PHE   A HD2  1 
ATOM   230  H  HE1  . PHE   A 1 22  ? 18.49478  15.21202  26.24641 1.000 35.33358  ? 965  PHE   A HE1  1 
ATOM   231  H  HE2  . PHE   A 1 22  ? 16.87949  16.92191  23.03630 1.000 47.44902  ? 965  PHE   A HE2  1 
ATOM   232  H  HZ   . PHE   A 1 22  ? 18.68645  15.94286  24.08969 1.000 41.28802  ? 965  PHE   A HZ   1 
ATOM   233  N  N    . GLN   A 1 23  ? 14.41107  14.52695  29.00243 1.000 44.80938  ? 966  GLN   A N    1 
ATOM   234  C  CA   . GLN   A 1 23  ? 15.38182  13.81359  29.81444 1.000 42.37145  ? 966  GLN   A CA   1 
ATOM   235  C  C    . GLN   A 1 23  ? 14.94079  12.39299  30.09097 1.000 39.67590  ? 966  GLN   A C    1 
ATOM   236  O  O    . GLN   A 1 23  ? 15.78569  11.50117  30.18830 1.000 31.56100  ? 966  GLN   A O    1 
ATOM   237  C  CB   . GLN   A 1 23  ? 15.60874  14.54572  31.12446 1.000 40.26800  ? 966  GLN   A CB   1 
ATOM   238  C  CG   . GLN   A 1 23  ? 16.40203  15.82183  30.94572 1.000 48.70957  ? 966  GLN   A CG   1 
ATOM   239  C  CD   . GLN   A 1 23  ? 16.28809  16.76715  32.11730 1.000 50.77575  ? 966  GLN   A CD   1 
ATOM   240  O  OE1  . GLN   A 1 23  ? 15.80488  16.40480  33.18396 1.000 57.78980  ? 966  GLN   A OE1  1 
ATOM   241  N  NE2  . GLN   A 1 23  ? 16.73052  18.00529  31.91553 1.000 55.00374  ? 966  GLN   A NE2  1 
ATOM   242  H  H    . GLN   A 1 23  ? 13.94536  15.10714  29.43381 1.000 53.78653  ? 966  GLN   A H    1 
ATOM   243  H  HA   . GLN   A 1 23  ? 16.22004  13.78410  29.32719 1.000 50.86102  ? 966  GLN   A HA   1 
ATOM   244  H  HB2  . GLN   A 1 23  ? 14.74955  14.77664  31.51095 1.000 48.33687  ? 966  GLN   A HB2  1 
ATOM   245  H  HB3  . GLN   A 1 23  ? 16.09993  13.96775  31.72910 1.000 48.33687  ? 966  GLN   A HB3  1 
ATOM   246  H  HG2  . GLN   A 1 23  ? 17.33896  15.59599  30.83598 1.000 58.46677  ? 966  GLN   A HG2  1 
ATOM   247  H  HG3  . GLN   A 1 23  ? 16.07785  16.28491  30.15745 1.000 58.46677  ? 966  GLN   A HG3  1 
ATOM   248  H  HE21 . GLN   A 1 23  ? 17.05751  18.22588  31.15132 1.000 66.01977  ? 966  GLN   A HE21 1 
ATOM   249  H  HE22 . GLN   A 1 23  ? 16.68956  18.58518  32.54929 1.000 66.01977  ? 966  GLN   A HE22 1 
ATOM   250  N  N    . SER   A 1 24  ? 13.63464  12.15394  30.26474 1.000 33.30997  ? 967  SER   A N    1 
ATOM   251  C  CA   . SER   A 1 24  ? 13.20841  10.79049  30.55412 1.000 40.68986  ? 967  SER   A CA   1 
ATOM   252  C  C    . SER   A 1 24  ? 13.17471  9.95884   29.28470 1.000 45.21613  ? 967  SER   A C    1 
ATOM   253  O  O    . SER   A 1 24  ? 13.42495  8.75445   29.34062 1.000 50.03015  ? 967  SER   A O    1 
ATOM   254  C  CB   . SER   A 1 24  ? 11.83590  10.76115  31.21577 1.000 48.04735  ? 967  SER   A CB   1 
ATOM   255  O  OG   . SER   A 1 24  ? 10.88827  11.33234  30.33911 1.000 42.12662  ? 967  SER   A OG   1 
ATOM   256  H  H    . SER   A 1 24  ? 13.00744  12.74072  30.22119 1.000 39.98724  ? 967  SER   A H    1 
ATOM   257  H  HA   . SER   A 1 24  ? 13.83353  10.40146  31.18561 1.000 48.84311  ? 967  SER   A HA   1 
ATOM   258  H  HB2  . SER   A 1 24  ? 11.58824  9.84250   31.40457 1.000 57.67209  ? 967  SER   A HB2  1 
ATOM   259  H  HB3  . SER   A 1 24  ? 11.86357  11.27321  32.03914 1.000 57.67209  ? 967  SER   A HB3  1 
ATOM   260  H  HG   . SER   A 1 24  ? 10.13025  11.34016  30.70096 1.000 50.56722  ? 967  SER   A HG   1 
ATOM   261  N  N    . VAL   A 1 25  ? 12.85559  10.57420  28.13994 1.000 39.39199  ? 968  VAL   A N    1 
ATOM   262  C  CA   . VAL   A 1 25  ? 12.98297  9.86810   26.87213 1.000 42.35203  ? 968  VAL   A CA   1 
ATOM   263  C  C    . VAL   A 1 25  ? 14.44529  9.54398   26.58555 1.000 42.53381  ? 968  VAL   A C    1 
ATOM   264  O  O    . VAL   A 1 25  ? 14.77143  8.40799   26.21776 1.000 40.48186  ? 968  VAL   A O    1 
ATOM   265  C  CB   . VAL   A 1 25  ? 12.34686  10.65640  25.71895 1.000 46.06027  ? 968  VAL   A CB   1 
ATOM   266  C  CG1  . VAL   A 1 25  ? 12.75023  10.02612  24.41300 1.000 37.05536  ? 968  VAL   A CG1  1 
ATOM   267  C  CG2  . VAL   A 1 25  ? 10.80816  10.64138  25.81760 1.000 44.39372  ? 968  VAL   A CG2  1 
ATOM   268  H  H    . VAL   A 1 25  ? 12.56957  11.38276  28.07660 1.000 47.28567  ? 968  VAL   A H    1 
ATOM   269  H  HA   . VAL   A 1 25  ? 12.49512  9.03357   26.95263 1.000 50.83771  ? 968  VAL   A HA   1 
ATOM   270  H  HB   . VAL   A 1 25  ? 12.65102  11.57634  25.76490 1.000 55.28760  ? 968  VAL   A HB   1 
ATOM   271  H  HG11 . VAL   A 1 25  ? 12.16616  10.35292  23.71090 1.000 44.48171  ? 968  VAL   A HG11 1 
ATOM   272  H  HG12 . VAL   A 1 25  ? 13.66941  10.26618  24.21708 1.000 44.48171  ? 968  VAL   A HG12 1 
ATOM   273  H  HG13 . VAL   A 1 25  ? 12.66904  9.06251   24.48901 1.000 44.48171  ? 968  VAL   A HG13 1 
ATOM   274  H  HG21 . VAL   A 1 25  ? 10.44262  11.23397  25.14224 1.000 53.28774  ? 968  VAL   A HG21 1 
ATOM   275  H  HG22 . VAL   A 1 25  ? 10.49109  9.73657   25.67039 1.000 53.28774  ? 968  VAL   A HG22 1 
ATOM   276  H  HG23 . VAL   A 1 25  ? 10.54537  10.94439  26.70079 1.000 53.28774  ? 968  VAL   A HG23 1 
ATOM   277  N  N    . GLU   A 1 26  ? 15.35656  10.51212  26.75545 1.000 35.90949  ? 969  GLU   A N    1 
ATOM   278  C  CA   . GLU   A 1 26  ? 16.76674  10.18654  26.54055 1.000 38.41669  ? 969  GLU   A CA   1 
ATOM   279  C  C    . GLU   A 1 26  ? 17.21887  9.05094   27.45352 1.000 41.39188  ? 969  GLU   A C    1 
ATOM   280  O  O    . GLU   A 1 26  ? 18.04537  8.21784   27.06169 1.000 41.60307  ? 969  GLU   A O    1 
ATOM   281  C  CB   . GLU   A 1 26  ? 17.69496  11.38722  26.75682 1.000 38.11307  ? 969  GLU   A CB   1 
ATOM   282  C  CG   . GLU   A 1 26  ? 19.15634  10.90598  26.88506 1.000 50.52765  ? 969  GLU   A CG   1 
ATOM   283  C  CD   . GLU   A 1 26  ? 20.21140  11.98877  26.80407 1.000 50.66566  ? 969  GLU   A CD   1 
ATOM   284  O  OE1  . GLU   A 1 26  ? 19.85883  13.16423  26.98644 1.000 46.43352  ? 969  GLU   A OE1  1 
ATOM   285  O  OE2  . GLU   A 1 26  ? 21.40298  11.63344  26.56792 1.000 50.37859  ? 969  GLU   A OE2  1 
ATOM   286  H  H    . GLU   A 1 26  ? 15.19012  11.32443  26.98357 1.000 43.10666  ? 969  GLU   A H    1 
ATOM   287  H  HA   . GLU   A 1 26  ? 16.84351  9.92263   25.61030 1.000 46.11530  ? 969  GLU   A HA   1 
ATOM   288  H  HB2  . GLU   A 1 26  ? 17.63013  11.99054  26.00004 1.000 45.75096  ? 969  GLU   A HB2  1 
ATOM   289  H  HB3  . GLU   A 1 26  ? 17.44583  11.84983  27.57219 1.000 45.75096  ? 969  GLU   A HB3  1 
ATOM   290  H  HG2  . GLU   A 1 26  ? 19.25897  10.46797  27.74443 1.000 60.64845  ? 969  GLU   A HG2  1 
ATOM   291  H  HG3  . GLU   A 1 26  ? 19.33428  10.27673  26.16862 1.000 60.64845  ? 969  GLU   A HG3  1 
ATOM   292  N  N    . GLU   A 1 27  ? 16.74573  9.06053   28.69579 1.000 40.97357  ? 970  GLU   A N    1 
ATOM   293  C  CA   . GLU   A 1 27  ? 17.16754  8.06982   29.66577 1.000 44.71541  ? 970  GLU   A CA   1 
ATOM   294  C  C    . GLU   A 1 27  ? 16.75188  6.68014   29.22975 1.000 42.35758  ? 970  GLU   A C    1 
ATOM   295  O  O    . GLU   A 1 27  ? 17.52382  5.72537   29.34649 1.000 37.82549  ? 970  GLU   A O    1 
ATOM   296  C  CB   . GLU   A 1 27  ? 16.55842  8.41022   31.02034 1.000 46.30204  ? 970  GLU   A CB   1 
ATOM   297  C  CG   . GLU   A 1 27  ? 16.77774  7.32143   32.06596 1.000 56.78689  ? 970  GLU   A CG   1 
ATOM   298  C  CD   . GLU   A 1 27  ? 18.24698  7.08622   32.34282 1.000 57.56937  ? 970  GLU   A CD   1 
ATOM   299  O  OE1  . GLU   A 1 27  ? 19.07292  7.84996   31.81115 1.000 67.85327  ? 970  GLU   A OE1  1 
ATOM   300  O  OE2  . GLU   A 1 27  ? 18.58637  6.13591   33.08028 1.000 69.74730  ? 970  GLU   A OE2  1 
ATOM   301  H  H    . GLU   A 1 27  ? 16.17910  9.63194   28.99914 1.000 49.18356  ? 970  GLU   A H    1 
ATOM   302  H  HA   . GLU   A 1 27  ? 18.13391  8.08170   29.74874 1.000 53.67377  ? 970  GLU   A HA   1 
ATOM   303  H  HB2  . GLU   A 1 27  ? 16.96315  9.22758   31.35050 1.000 55.57772  ? 970  GLU   A HB2  1 
ATOM   304  H  HB3  . GLU   A 1 27  ? 15.60227  8.53331   30.91301 1.000 55.57772  ? 970  GLU   A HB3  1 
ATOM   305  H  HG2  . GLU   A 1 27  ? 16.35179  7.58641   32.89617 1.000 68.15954  ? 970  GLU   A HG2  1 
ATOM   306  H  HG3  . GLU   A 1 27  ? 16.39303  6.49037   31.74621 1.000 68.15954  ? 970  GLU   A HG3  1 
ATOM   307  N  N    . GLU   A 1 28  ? 15.51534  6.55182   28.75460 1.000 42.24242  ? 971  GLU   A N    1 
ATOM   308  C  CA   . GLU   A 1 28  ? 15.01606  5.28511   28.23950 1.000 42.72925  ? 971  GLU   A CA   1 
ATOM   309  C  C    . GLU   A 1 28  ? 15.81846  4.83499   27.02329 1.000 40.48478  ? 971  GLU   A C    1 
ATOM   310  O  O    . GLU   A 1 28  ? 16.16256  3.65970   26.87324 1.000 39.57428  ? 971  GLU   A O    1 
ATOM   311  C  CB   . GLU   A 1 28  ? 13.53781  5.46112   27.91512 1.000 39.95661  ? 971  GLU   A CB   1 
ATOM   312  C  CG   . GLU   A 1 28  ? 12.70580  4.20263   27.90436 1.000 64.69518  ? 971  GLU   A CG   1 
ATOM   313  C  CD   . GLU   A 1 28  ? 12.71798  3.45323   29.21627 1.000 60.26182  ? 971  GLU   A CD   1 
ATOM   314  O  OE1  . GLU   A 1 28  ? 13.12628  4.04410   30.25836 1.000 68.59538  ? 971  GLU   A OE1  1 
ATOM   315  O  OE2  . GLU   A 1 28  ? 12.29473  2.27449   29.17499 1.000 61.86213  ? 971  GLU   A OE2  1 
ATOM   316  H  H    . GLU   A 1 28  ? 14.94022  7.19025   28.71934 1.000 50.70618  ? 971  GLU   A H    1 
ATOM   317  H  HA   . GLU   A 1 28  ? 15.10401  4.58272   28.90269 1.000 51.29038  ? 971  GLU   A HA   1 
ATOM   318  H  HB2  . GLU   A 1 28  ? 13.15100  6.05404   28.57824 1.000 47.96321  ? 971  GLU   A HB2  1 
ATOM   319  H  HB3  . GLU   A 1 28  ? 13.46678  5.85848   27.03310 1.000 47.96321  ? 971  GLU   A HB3  1 
ATOM   320  H  HG2  . GLU   A 1 28  ? 11.78578  4.43830   27.70706 1.000 77.64949  ? 971  GLU   A HG2  1 
ATOM   321  H  HG3  . GLU   A 1 28  ? 13.04965  3.60690   27.22041 1.000 77.64949  ? 971  GLU   A HG3  1 
ATOM   322  N  N    . MET   A 1 29  ? 16.17343  5.76056   26.16454 1.000 42.60442  ? 972  MET   A N    1 
ATOM   323  C  CA   . MET   A 1 29  ? 17.02503  5.41989   25.04058 1.000 43.98686  ? 972  MET   A CA   1 
ATOM   324  C  C    . MET   A 1 29  ? 18.36252  4.85492   25.51649 1.000 40.86512  ? 972  MET   A C    1 
ATOM   325  O  O    . MET   A 1 29  ? 18.77407  3.77099   25.07950 1.000 35.01807  ? 972  MET   A O    1 
ATOM   326  C  CB   . MET   A 1 29  ? 17.18652  6.67206   24.18685 1.000 42.30039  ? 972  MET   A CB   1 
ATOM   327  C  CG   . MET   A 1 29  ? 18.00921  6.50235   22.99716 1.000 48.84199  ? 972  MET   A CG   1 
ATOM   328  S  SD   . MET   A 1 29  ? 17.03357  6.09368   21.59894 1.000 45.41860  ? 972  MET   A SD   1 
ATOM   329  C  CE   . MET   A 1 29  ? 18.33553  6.27507   20.40028 1.000 40.12004  ? 972  MET   A CE   1 
ATOM   330  H  H    . MET   A 1 29  ? 15.94021  6.58738   26.20419 1.000 51.14058  ? 972  MET   A H    1 
ATOM   331  H  HA   . MET   A 1 29  ? 16.61433  4.73316   24.49229 1.000 52.79951  ? 972  MET   A HA   1 
ATOM   332  H  HB2  . MET   A 1 29  ? 16.30760  6.95988   23.89433 1.000 50.77575  ? 972  MET   A HB2  1 
ATOM   333  H  HB3  . MET   A 1 29  ? 17.59827  7.36274   24.72937 1.000 50.77575  ? 972  MET   A HB3  1 
ATOM   334  H  HG2  . MET   A 1 29  ? 18.47932  7.33008   22.81072 1.000 58.62567  ? 972  MET   A HG2  1 
ATOM   335  H  HG3  . MET   A 1 29  ? 18.64565  5.78564   23.14606 1.000 58.62567  ? 972  MET   A HG3  1 
ATOM   336  H  HE1  . MET   A 1 29  ? 17.96445  6.16131   19.51132 1.000 48.15932  ? 972  MET   A HE1  1 
ATOM   337  H  HE2  . MET   A 1 29  ? 18.72287  7.16021   20.48626 1.000 48.15932  ? 972  MET   A HE2  1 
ATOM   338  H  HE3  . MET   A 1 29  ? 19.01262  5.60028   20.56492 1.000 48.15932  ? 972  MET   A HE3  1 
ATOM   339  N  N    . GLN   A 1 30  ? 19.02982  5.53710   26.46163 1.000 37.11306  ? 973  GLN   A N    1 
ATOM   340  C  CA   . GLN   A 1 30  ? 20.40732  5.18563   26.81279 1.000 44.24707  ? 973  GLN   A CA   1 
ATOM   341  C  C    . GLN   A 1 30  ? 20.46438  3.94598   27.68388 1.000 45.68303  ? 973  GLN   A C    1 
ATOM   342  O  O    . GLN   A 1 30  ? 21.40082  3.14768   27.57645 1.000 43.96961  ? 973  GLN   A O    1 
ATOM   343  C  CB   . GLN   A 1 30  ? 21.11215  6.32734   27.55359 1.000 41.75752  ? 973  GLN   A CB   1 
ATOM   344  C  CG   . GLN   A 1 30  ? 21.24236  7.62004   26.75729 1.000 43.01570  ? 973  GLN   A CG   1 
ATOM   345  C  CD   . GLN   A 1 30  ? 22.45443  7.67283   25.84737 1.000 45.86022  ? 973  GLN   A CD   1 
ATOM   346  O  OE1  . GLN   A 1 30  ? 23.03794  6.64875   25.47311 1.000 40.28446  ? 973  GLN   A OE1  1 
ATOM   347  N  NE2  . GLN   A 1 30  ? 22.85809  8.88851   25.49876 1.000 48.40651  ? 973  GLN   A NE2  1 
ATOM   348  H  H    . GLN   A 1 30  ? 18.70838  6.19894   26.90688 1.000 44.55095  ? 973  GLN   A H    1 
ATOM   349  H  HA   . GLN   A 1 30  ? 20.87722  5.02583   25.97939 1.000 53.11177  ? 973  GLN   A HA   1 
ATOM   350  H  HB2  . GLN   A 1 30  ? 20.60907  6.52939   28.35794 1.000 50.12430  ? 973  GLN   A HB2  1 
ATOM   351  H  HB3  . GLN   A 1 30  ? 22.00772  6.03661   27.78667 1.000 50.12430  ? 973  GLN   A HB3  1 
ATOM   352  H  HG2  . GLN   A 1 30  ? 20.45381  7.72298   26.20186 1.000 51.63411  ? 973  GLN   A HG2  1 
ATOM   353  H  HG3  . GLN   A 1 30  ? 21.30952  8.36176   27.37878 1.000 51.63411  ? 973  GLN   A HG3  1 
ATOM   354  H  HE21 . GLN   A 1 30  ? 22.43727  9.58065   25.78765 1.000 58.10309  ? 973  GLN   A HE21 1 
ATOM   355  H  HE22 . GLN   A 1 30  ? 23.54040  8.98391   24.98404 1.000 58.10309  ? 973  GLN   A HE22 1 
ATOM   356  N  N    . SER   A 1 31  ? 19.48506  3.77868   28.55993 1.000 42.88483  ? 974  SER   A N    1 
ATOM   357  C  CA   . SER   A 1 31  ? 19.54792  2.70113   29.52419 1.000 39.16701  ? 974  SER   A CA   1 
ATOM   358  C  C    . SER   A 1 31  ? 19.11353  1.35911   28.96043 1.000 42.83848  ? 974  SER   A C    1 
ATOM   359  O  O    . SER   A 1 31  ? 19.27143  0.35395   29.64712 1.000 48.89592  ? 974  SER   A O    1 
ATOM   360  C  CB   . SER   A 1 31  ? 18.68626  3.02890   30.74110 1.000 34.74667  ? 974  SER   A CB   1 
ATOM   361  O  OG   . SER   A 1 31  ? 17.33841  2.97042   30.40278 1.000 47.99325  ? 974  SER   A OG   1 
ATOM   362  H  H    . SER   A 1 31  ? 18.78261  4.27196   28.61324 1.000 51.47708  ? 974  SER   A H    1 
ATOM   363  H  HA   . SER   A 1 31  ? 20.46915  2.61732   29.81610 1.000 47.01569  ? 974  SER   A HA   1 
ATOM   364  H  HB2  . SER   A 1 31  ? 18.86699  2.38378   31.44256 1.000 41.71127  ? 974  SER   A HB2  1 
ATOM   365  H  HB3  . SER   A 1 31  ? 18.89865  3.92343   31.05029 1.000 41.71127  ? 974  SER   A HB3  1 
ATOM   366  H  HG   . SER   A 1 31  ? 17.14041  3.61307   29.89940 1.000 57.60718  ? 974  SER   A HG   1 
ATOM   367  N  N    . THR   A 1 32  ? 18.57648  1.30367   27.74291 1.000 41.89984  ? 975  THR   A N    1 
ATOM   368  C  CA   . THR   A 1 32  ? 18.16595  0.03965   27.15364 1.000 42.66708  ? 975  THR   A CA   1 
ATOM   369  C  C    . THR   A 1 32  ? 19.09761  -0.39703  26.02800 1.000 41.44704  ? 975  THR   A C    1 
ATOM   370  O  O    . THR   A 1 32  ? 18.74149  -1.28175  25.24560 1.000 40.49846  ? 975  THR   A O    1 
ATOM   371  C  CB   . THR   A 1 32  ? 16.72557  0.11403   26.66258 1.000 35.35793  ? 975  THR   A CB   1 
ATOM   372  O  OG1  . THR   A 1 32  ? 16.60936  1.08804   25.63386 1.000 33.20153  ? 975  THR   A OG1  1 
ATOM   373  C  CG2  . THR   A 1 32  ? 15.81544  0.53355   27.76456 1.000 39.12687  ? 975  THR   A CG2  1 
ATOM   374  H  H    . THR   A 1 32  ? 18.44119  1.98868   27.24086 1.000 50.29509  ? 975  THR   A H    1 
ATOM   375  H  HA   . THR   A 1 32  ? 18.19877  -0.64213  27.84285 1.000 51.21577  ? 975  THR   A HA   1 
ATOM   376  H  HB   . THR   A 1 32  ? 16.46997  -0.76264  26.33545 1.000 42.44479  ? 975  THR   A HB   1 
ATOM   377  H  HG1  . THR   A 1 32  ? 16.77612  1.85180   25.94119 1.000 39.85711  ? 975  THR   A HG1  1 
ATOM   378  H  HG21 . THR   A 1 32  ? 14.89569  0.52529   27.45651 1.000 46.96752  ? 975  THR   A HG21 1 
ATOM   379  H  HG22 . THR   A 1 32  ? 15.90140  -0.07446  28.51545 1.000 46.96752  ? 975  THR   A HG22 1 
ATOM   380  H  HG23 . THR   A 1 32  ? 16.04110  1.43012   28.05805 1.000 46.96752  ? 975  THR   A HG23 1 
ATOM   381  N  N    . VAL   A 1 33  ? 20.30008  0.18046   25.95330 1.000 42.20753  ? 976  VAL   A N    1 
ATOM   382  C  CA   . VAL   A 1 33  ? 21.31192  -0.30390  25.02791 1.000 38.93250  ? 976  VAL   A CA   1 
ATOM   383  C  C    . VAL   A 1 33  ? 21.83453  -1.64846  25.51341 1.000 40.12802  ? 976  VAL   A C    1 
ATOM   384  O  O    . VAL   A 1 33  ? 22.05327  -1.84072  26.70644 1.000 33.32635  ? 976  VAL   A O    1 
ATOM   385  C  CB   . VAL   A 1 33  ? 22.45651  0.71214   24.91911 1.000 37.88651  ? 976  VAL   A CB   1 
ATOM   386  C  CG1  . VAL   A 1 33  ? 23.58552  0.13959   24.14359 1.000 33.97986  ? 976  VAL   A CG1  1 
ATOM   387  C  CG2  . VAL   A 1 33  ? 21.96679  1.99587   24.28093 1.000 45.42414  ? 976  VAL   A CG2  1 
ATOM   388  H  H    . VAL   A 1 33  ? 20.54931  0.85238   26.42870 1.000 50.66431  ? 976  VAL   A H    1 
ATOM   389  H  HA   . VAL   A 1 33  ? 20.91403  -0.41865  24.15074 1.000 46.73428  ? 976  VAL   A HA   1 
ATOM   390  H  HB   . VAL   A 1 33  ? 22.77714  0.92159   25.81030 1.000 45.47909  ? 976  VAL   A HB   1 
ATOM   391  H  HG11 . VAL   A 1 33  ? 24.13204  0.86365   23.80015 1.000 40.79111  ? 976  VAL   A HG11 1 
ATOM   392  H  HG12 . VAL   A 1 33  ? 24.11478  -0.42618  24.72726 1.000 40.79111  ? 976  VAL   A HG12 1 
ATOM   393  H  HG13 . VAL   A 1 33  ? 23.23023  -0.38407  23.40843 1.000 40.79111  ? 976  VAL   A HG13 1 
ATOM   394  H  HG21 . VAL   A 1 33  ? 22.70546  2.62198   24.22388 1.000 54.52424  ? 976  VAL   A HG21 1 
ATOM   395  H  HG22 . VAL   A 1 33  ? 21.63088  1.79877   23.39255 1.000 54.52424  ? 976  VAL   A HG22 1 
ATOM   396  H  HG23 . VAL   A 1 33  ? 21.25778  2.36967   24.82725 1.000 54.52424  ? 976  VAL   A HG23 1 
ATOM   397  N  N    . ARG   A 1 34  ? 22.04704  -2.59172  24.60038 1.000 38.75953  ? 977  ARG   A N    1 
ATOM   398  C  CA   . ARG   A 1 34  ? 22.68206  -3.84184  24.99659 1.000 36.17562  ? 977  ARG   A CA   1 
ATOM   399  C  C    . ARG   A 1 34  ? 23.61783  -4.30320  23.90278 1.000 35.01274  ? 977  ARG   A C    1 
ATOM   400  O  O    . ARG   A 1 34  ? 23.60708  -3.77883  22.79507 1.000 43.88631  ? 977  ARG   A O    1 
ATOM   401  C  CB   . ARG   A 1 34  ? 21.65814  -4.92770  25.30646 1.000 31.17132  ? 977  ARG   A CB   1 
ATOM   402  C  CG   . ARG   A 1 34  ? 20.91426  -5.47623  24.11899 1.000 36.34527  ? 977  ARG   A CG   1 
ATOM   403  C  CD   . ARG   A 1 34  ? 19.93919  -6.58329  24.55544 1.000 38.98544  ? 977  ARG   A CD   1 
ATOM   404  N  NE   . ARG   A 1 34  ? 19.06354  -7.04033  23.48454 1.000 36.60157  ? 977  ARG   A NE   1 
ATOM   405  C  CZ   . ARG   A 1 34  ? 19.45888  -7.85212  22.51738 1.000 33.60513  ? 977  ARG   A CZ   1 
ATOM   406  N  NH1  . ARG   A 1 34  ? 20.72056  -8.23529  22.41539 1.000 37.53342  ? 977  ARG   A NH1  1 
ATOM   407  N  NH2  . ARG   A 1 34  ? 18.56442  -8.31018  21.64830 1.000 35.80050  ? 977  ARG   A NH2  1 
ATOM   408  H  H    . ARG   A 1 34  ? 21.83759  -2.53143  23.76845 1.000 46.52672  ? 977  ARG   A H    1 
ATOM   409  H  HA   . ARG   A 1 34  ? 23.20622  -3.67898  25.79637 1.000 43.42602  ? 977  ARG   A HA   1 
ATOM   410  H  HB2  . ARG   A 1 34  ? 22.11931  -5.67066  25.72627 1.000 37.42086  ? 977  ARG   A HB2  1 
ATOM   411  H  HB3  . ARG   A 1 34  ? 20.99860  -4.55994  25.91528 1.000 37.42086  ? 977  ARG   A HB3  1 
ATOM   412  H  HG2  . ARG   A 1 34  ? 20.40588  -4.76562  23.69769 1.000 43.62960  ? 977  ARG   A HG2  1 
ATOM   413  H  HG3  . ARG   A 1 34  ? 21.54546  -5.85279  23.48600 1.000 43.62960  ? 977  ARG   A HG3  1 
ATOM   414  H  HD2  . ARG   A 1 34  ? 20.45042  -7.34655  24.86686 1.000 46.79781  ? 977  ARG   A HD2  1 
ATOM   415  H  HD3  . ARG   A 1 34  ? 19.37989  -6.24406  25.27168 1.000 46.79781  ? 977  ARG   A HD3  1 
ATOM   416  H  HE   . ARG   A 1 34  ? 18.24765  -6.76847  23.48081 1.000 43.93716  ? 977  ARG   A HE   1 
ATOM   417  H  HH11 . ARG   A 1 34  ? 21.30201  -7.95629  22.98432 1.000 45.05538  ? 977  ARG   A HH11 1 
ATOM   418  H  HH12 . ARG   A 1 34  ? 20.95954  -8.76344  21.78014 1.000 45.05538  ? 977  ARG   A HH12 1 
ATOM   419  H  HH21 . ARG   A 1 34  ? 17.73917  -8.07850  21.71818 1.000 42.97587  ? 977  ARG   A HH21 1 
ATOM   420  H  HH22 . ARG   A 1 34  ? 18.81069  -8.83836  21.01586 1.000 42.97587  ? 977  ARG   A HH22 1 
ATOM   421  N  N    . GLU   A 1 35  ? 24.44424  -5.29264  24.22328 1.000 40.34559  ? 978  GLU   A N    1 
ATOM   422  C  CA   . GLU   A 1 35  ? 25.24904  -5.94065  23.18824 1.000 43.30299  ? 978  GLU   A CA   1 
ATOM   423  C  C    . GLU   A 1 35  ? 24.36909  -6.91685  22.41755 1.000 35.27049  ? 978  GLU   A C    1 
ATOM   424  O  O    . GLU   A 1 35  ? 23.36662  -7.42394  22.92365 1.000 40.18172  ? 978  GLU   A O    1 
ATOM   425  C  CB   . GLU   A 1 35  ? 26.44863  -6.68188  23.79003 1.000 45.68439  ? 978  GLU   A CB   1 
ATOM   426  C  CG   . GLU   A 1 35  ? 27.25835  -5.85720  24.78158 1.000 66.55366  ? 978  GLU   A CG   1 
ATOM   427  C  CD   . GLU   A 1 35  ? 28.66457  -6.40510  25.05685 1.000 75.16325  ? 978  GLU   A CD   1 
ATOM   428  O  OE1  . GLU   A 1 35  ? 28.84447  -7.63647  25.14158 1.000 65.20725  ? 978  GLU   A OE1  1 
ATOM   429  O  OE2  . GLU   A 1 35  ? 29.59652  -5.58542  25.19713 1.000 77.39687  ? 978  GLU   A OE2  1 
ATOM   430  H  H    . GLU   A 1 35  ? 24.55675  -5.60313  25.01734 1.000 48.42998  ? 978  GLU   A H    1 
ATOM   431  H  HA   . GLU   A 1 35  ? 25.60671  -5.27317  22.58206 1.000 51.97886  ? 978  GLU   A HA   1 
ATOM   432  H  HB2  . GLU   A 1 35  ? 26.12498  -7.46837  24.25650 1.000 54.83655  ? 978  GLU   A HB2  1 
ATOM   433  H  HB3  . GLU   A 1 35  ? 27.04374  -6.94441  23.07044 1.000 54.83655  ? 978  GLU   A HB3  1 
ATOM   434  H  HG2  . GLU   A 1 35  ? 27.35707  -4.95853  24.43010 1.000 79.87967  ? 978  GLU   A HG2  1 
ATOM   435  H  HG3  . GLU   A 1 35  ? 26.78233  -5.83259  25.62639 1.000 79.87967  ? 978  GLU   A HG3  1 
ATOM   436  N  N    . HIS   A 1 36  ? 24.72397  -7.15144  21.17063 1.000 31.24795  ? 979  HIS   A N    1 
ATOM   437  C  CA   . HIS   A 1 36  ? 23.93715  -7.99440  20.29826 1.000 35.92079  ? 979  HIS   A CA   1 
ATOM   438  C  C    . HIS   A 1 36  ? 24.78333  -9.16760  19.84571 1.000 37.98339  ? 979  HIS   A C    1 
ATOM   439  O  O    . HIS   A 1 36  ? 26.00422  -9.06201  19.70517 1.000 34.16368  ? 979  HIS   A O    1 
ATOM   440  C  CB   . HIS   A 1 36  ? 23.40037  -7.17137  19.13814 1.000 29.69384  ? 979  HIS   A CB   1 
ATOM   441  C  CG   . HIS   A 1 36  ? 22.33495  -6.22229  19.57130 1.000 35.28214  ? 979  HIS   A CG   1 
ATOM   442  N  ND1  . HIS   A 1 36  ? 20.99830  -6.55247  19.54771 1.000 38.25434  ? 979  HIS   A ND1  1 
ATOM   443  C  CD2  . HIS   A 1 36  ? 22.40683  -5.01215  20.17636 1.000 34.22477  ? 979  HIS   A CD2  1 
ATOM   444  C  CE1  . HIS   A 1 36  ? 20.28707  -5.55767  20.04429 1.000 36.66950  ? 979  HIS   A CE1  1 
ATOM   445  N  NE2  . HIS   A 1 36  ? 21.11840  -4.61210  20.44228 1.000 33.55377  ? 979  HIS   A NE2  1 
ATOM   446  H  H    . HIS   A 1 36  ? 25.42953  -6.82729  20.80089 1.000 37.51282  ? 979  HIS   A H    1 
ATOM   447  H  HA   . HIS   A 1 36  ? 23.17004  -8.37641  20.75271 1.000 43.12022  ? 979  HIS   A HA   1 
ATOM   448  H  HB2  . HIS   A 1 36  ? 24.12546  -6.65694  18.75018 1.000 35.64789  ? 979  HIS   A HB2  1 
ATOM   449  H  HB3  . HIS   A 1 36  ? 23.02322  -7.76748  18.47232 1.000 35.64789  ? 979  HIS   A HB3  1 
ATOM   450  H  HD1  . HIS   A 1 36  ? 20.67607  -7.29382  19.25418 1.000 45.92048  ? 979  HIS   A HD1  1 
ATOM   451  H  HD2  . HIS   A 1 36  ? 23.18307  -4.53998  20.37488 1.000 41.08500  ? 979  HIS   A HD2  1 
ATOM   452  H  HE1  . HIS   A 1 36  ? 19.35945  -5.52780  20.10369 1.000 44.01868  ? 979  HIS   A HE1  1 
ATOM   453  N  N    . ARG   A 1 37  ? 24.10713  -10.29618 19.61479 1.000 40.73473  ? 980  ARG   A N    1 
ATOM   454  C  CA   . ARG   A 1 37  ? 24.81372  -11.54552 19.32253 1.000 42.31113  ? 980  ARG   A CA   1 
ATOM   455  C  C    . ARG   A 1 37  ? 25.59085  -11.49732 18.02023 1.000 36.86031  ? 980  ARG   A C    1 
ATOM   456  O  O    . ARG   A 1 37  ? 26.36938  -12.41372 17.76187 1.000 36.55284  ? 980  ARG   A O    1 
ATOM   457  C  CB   . ARG   A 1 37  ? 23.82740  -12.71510 19.26835 1.000 42.75160  ? 980  ARG   A CB   1 
ATOM   458  C  CG   . ARG   A 1 37  ? 22.94065  -12.87089 20.49655 1.000 52.45104  ? 980  ARG   A CG   1 
ATOM   459  C  CD   . ARG   A 1 37  ? 21.79952  -13.87768 20.26263 1.000 62.68953  ? 980  ARG   A CD   1 
ATOM   460  N  NE   . ARG   A 1 37  ? 22.25730  -15.24748 20.46606 1.000 81.20482  ? 980  ARG   A NE   1 
ATOM   461  C  CZ   . ARG   A 1 37  ? 21.46335  -16.30894 20.52787 1.000 100.80043 ? 980  ARG   A CZ   1 
ATOM   462  N  NH1  . ARG   A 1 37  ? 20.15167  -16.20050 20.35432 1.000 100.88709 ? 980  ARG   A NH1  1 
ATOM   463  N  NH2  . ARG   A 1 37  ? 21.99833  -17.50578 20.78724 1.000 80.40317  ? 980  ARG   A NH2  1 
ATOM   464  H  H    . ARG   A 1 37  ? 23.24986  -10.36422 19.62142 1.000 48.89695  ? 980  ARG   A H    1 
ATOM   465  H  HA   . ARG   A 1 37  ? 25.44086  -11.70653 20.04480 1.000 50.78863  ? 980  ARG   A HA   1 
ATOM   466  H  HB2  . ARG   A 1 37  ? 23.24432  -12.58905 18.50349 1.000 51.31719  ? 980  ARG   A HB2  1 
ATOM   467  H  HB3  . ARG   A 1 37  ? 24.33227  -13.53734 19.16870 1.000 51.31719  ? 980  ARG   A HB3  1 
ATOM   468  H  HG2  . ARG   A 1 37  ? 23.47727  -13.18924 21.23924 1.000 62.95652  ? 980  ARG   A HG2  1 
ATOM   469  H  HG3  . ARG   A 1 37  ? 22.54617  -12.01240 20.71627 1.000 62.95652  ? 980  ARG   A HG3  1 
ATOM   470  H  HD2  . ARG   A 1 37  ? 21.07892  -13.69925 20.88698 1.000 75.24271  ? 980  ARG   A HD2  1 
ATOM   471  H  HD3  . ARG   A 1 37  ? 21.47737  -13.79412 19.35151 1.000 75.24271  ? 980  ARG   A HD3  1 
ATOM   472  H  HE   . ARG   A 1 37  ? 23.10318  -15.37661 20.55221 1.000 97.46105  ? 980  ARG   A HE   1 
ATOM   473  H  HH11 . ARG   A 1 37  ? 19.80073  -15.43103 20.19827 1.000 121.07979 ? 980  ARG   A HH11 1 
ATOM   474  H  HH12 . ARG   A 1 37  ? 19.65289  -16.89973 20.39794 1.000 121.07979 ? 980  ARG   A HH12 1 
ATOM   475  H  HH21 . ARG   A 1 37  ? 22.84607  -17.58007 20.91136 1.000 96.49908  ? 980  ARG   A HH21 1 
ATOM   476  H  HH22 . ARG   A 1 37  ? 21.49486  -18.20168 20.83002 1.000 96.49908  ? 980  ARG   A HH22 1 
ATOM   477  N  N    . ASP   A 1 38  ? 25.39600  -10.46611 17.19091 1.000 35.74990  ? 981  ASP   A N    1 
ATOM   478  C  CA   . ASP   A 1 38  ? 26.14229  -10.32027 15.95504 1.000 31.04140  ? 981  ASP   A CA   1 
ATOM   479  C  C    . ASP   A 1 38  ? 27.37018  -9.45973  16.12454 1.000 38.76315  ? 981  ASP   A C    1 
ATOM   480  O  O    . ASP   A 1 38  ? 27.97563  -9.06773  15.12045 1.000 38.16275  ? 981  ASP   A O    1 
ATOM   481  C  CB   . ASP   A 1 38  ? 25.25448  -9.75078  14.85005 1.000 33.50350  ? 981  ASP   A CB   1 
ATOM   482  C  CG   . ASP   A 1 38  ? 24.96923  -8.24232  15.00718 1.000 38.61725  ? 981  ASP   A CG   1 
ATOM   483  O  OD1  . ASP   A 1 38  ? 25.34494  -7.62959  16.02377 1.000 32.34339  ? 981  ASP   A OD1  1 
ATOM   484  O  OD2  . ASP   A 1 38  ? 24.35349  -7.68873  14.07949 1.000 36.01890  ? 981  ASP   A OD2  1 
ATOM   485  H  H    . ASP   A 1 38  ? 24.82859  -9.83533  17.33148 1.000 42.91515  ? 981  ASP   A H    1 
ATOM   486  H  HA   . ASP   A 1 38  ? 26.42811  -11.20100 15.66605 1.000 37.26496  ? 981  ASP   A HA   1 
ATOM   487  H  HB2  . ASP   A 1 38  ? 25.69435  -9.88237  13.99559 1.000 40.21948  ? 981  ASP   A HB2  1 
ATOM   488  H  HB3  . ASP   A 1 38  ? 24.40366  -10.21652 14.86039 1.000 40.21948  ? 981  ASP   A HB3  1 
ATOM   489  N  N    . GLY   A 1 39  ? 27.73609  -9.14567  17.36116 1.000 39.80921  ? 982  GLY   A N    1 
ATOM   490  C  CA   . GLY   A 1 39  ? 28.93235  -8.36545  17.60657 1.000 39.37817  ? 982  GLY   A CA   1 
ATOM   491  C  C    . GLY   A 1 39  ? 28.91806  -6.96991  17.02264 1.000 40.57100  ? 982  GLY   A C    1 
ATOM   492  O  O    . GLY   A 1 39  ? 29.97919  -6.36318  16.88165 1.000 41.69449  ? 982  GLY   A O    1 
ATOM   493  H  H    . GLY   A 1 39  ? 27.30799  -9.37306  18.07152 1.000 47.78633  ? 982  GLY   A H    1 
ATOM   494  H  HA2  . GLY   A 1 39  ? 29.05730  -8.28275  18.56493 1.000 47.26908  ? 982  GLY   A HA2  1 
ATOM   495  H  HA3  . GLY   A 1 39  ? 29.69197  -8.83546  17.22845 1.000 47.26908  ? 982  GLY   A HA3  1 
ATOM   496  N  N    . GLY   A 1 40  ? 27.75275  -6.44122  16.66682 1.000 41.59425  ? 983  GLY   A N    1 
ATOM   497  C  CA   . GLY   A 1 40  ? 27.65719  -5.09884  16.11012 1.000 39.45982  ? 983  GLY   A CA   1 
ATOM   498  C  C    . GLY   A 1 40  ? 27.50773  -5.08030  14.61458 1.000 44.64553  ? 983  GLY   A C    1 
ATOM   499  O  O    . GLY   A 1 40  ? 27.59967  -4.01116  13.99908 1.000 32.80851  ? 983  GLY   A O    1 
ATOM   500  H  H    . GLY   A 1 40  ? 26.99655  -6.84440  16.73896 1.000 49.92838  ? 983  GLY   A H    1 
ATOM   501  H  HA2  . GLY   A 1 40  ? 26.88826  -4.65078  16.49598 1.000 47.36706  ? 983  GLY   A HA2  1 
ATOM   502  H  HA3  . GLY   A 1 40  ? 28.45918  -4.60381  16.33957 1.000 47.36706  ? 983  GLY   A HA3  1 
ATOM   503  N  N    . HIS   A 1 41  ? 27.28138  -6.23618  14.00486 1.000 42.59005  ? 984  HIS   A N    1 
ATOM   504  C  CA   . HIS   A 1 41  ? 27.31247  -6.31230  12.55684 1.000 37.27347  ? 984  HIS   A CA   1 
ATOM   505  C  C    . HIS   A 1 41  ? 26.18518  -5.50138  11.91510 1.000 37.73811  ? 984  HIS   A C    1 
ATOM   506  O  O    . HIS   A 1 41  ? 26.42687  -4.72567  10.99018 1.000 43.91644  ? 984  HIS   A O    1 
ATOM   507  C  CB   . HIS   A 1 41  ? 27.24319  -7.77661  12.13076 1.000 43.75846  ? 984  HIS   A CB   1 
ATOM   508  C  CG   . HIS   A 1 41  ? 27.31941  -7.94088  10.65735 1.000 34.64346  ? 984  HIS   A CG   1 
ATOM   509  N  ND1  . HIS   A 1 41  ? 28.51958  -8.03928  9.99080  1.000 35.16638  ? 984  HIS   A ND1  1 
ATOM   510  C  CD2  . HIS   A 1 41  ? 26.35530  -7.93709  9.71406  1.000 36.86040  ? 984  HIS   A CD2  1 
ATOM   511  C  CE1  . HIS   A 1 41  ? 28.28443  -8.11310  8.69432  1.000 41.53045  ? 984  HIS   A CE1  1 
ATOM   512  N  NE2  . HIS   A 1 41  ? 26.97951  -8.05999  8.50363  1.000 43.49558  ? 984  HIS   A NE2  1 
ATOM   513  H  H    . HIS   A 1 41  ? 27.11006  -6.97935  14.40228 1.000 51.12333  ? 984  HIS   A H    1 
ATOM   514  H  HA   . HIS   A 1 41  ? 28.14760  -5.93360  12.24053 1.000 44.74345  ? 984  HIS   A HA   1 
ATOM   515  H  HB2  . HIS   A 1 41  ? 27.98643  -8.25775  12.52699 1.000 52.52543  ? 984  HIS   A HB2  1 
ATOM   516  H  HB3  . HIS   A 1 41  ? 26.40330  -8.15569  12.43371 1.000 52.52543  ? 984  HIS   A HB3  1 
ATOM   517  H  HD2  . HIS   A 1 41  ? 25.43958  -7.86463  9.85936  1.000 44.24776  ? 984  HIS   A HD2  1 
ATOM   518  H  HE1  . HIS   A 1 41  ? 28.92882  -8.18956  8.02813  1.000 49.85181  ? 984  HIS   A HE1  1 
ATOM   519  H  HE2  . HIS   A 1 41  ? 26.58499  -8.09679  7.74035  1.000 52.20997  ? 984  HIS   A HE2  1 
ATOM   520  N  N    . ALA   A 1 42  ? 24.93958  -5.67237  12.37217 1.000 30.09720  ? 985  ALA   A N    1 
ATOM   521  C  CA   . ALA   A 1 42  ? 23.83492  -4.94575  11.73855 1.000 37.75643  ? 985  ALA   A CA   1 
ATOM   522  C  C    . ALA   A 1 42  ? 23.82403  -3.46698  12.12838 1.000 33.46542  ? 985  ALA   A C    1 
ATOM   523  O  O    . ALA   A 1 42  ? 23.61518  -2.60155  11.27974 1.000 37.77583  ? 985  ALA   A O    1 
ATOM   524  C  CB   . ALA   A 1 42  ? 22.48016  -5.56894  12.09472 1.000 33.63786  ? 985  ALA   A CB   1 
ATOM   525  H  H    . ALA   A 1 42  ? 24.71507  -6.18532  13.02492 1.000 36.13192  ? 985  ALA   A H    1 
ATOM   526  H  HA   . ALA   A 1 42  ? 23.96593  -5.01863  10.78021 1.000 45.32299  ? 985  ALA   A HA   1 
ATOM   527  H  HB1  . ALA   A 1 42  ? 21.77727  -5.07576  11.64349 1.000 40.38071  ? 985  ALA   A HB1  1 
ATOM   528  H  HB2  . ALA   A 1 42  ? 22.47265  -6.49480  11.80555 1.000 40.38071  ? 985  ALA   A HB2  1 
ATOM   529  H  HB3  . ALA   A 1 42  ? 22.35341  -5.52136  13.05523 1.000 40.38071  ? 985  ALA   A HB3  1 
ATOM   530  N  N    . GLY   A 1 43  ? 24.00161  -3.16516  13.41312 1.000 32.08942  ? 986  GLY   A N    1 
ATOM   531  C  CA   . GLY   A 1 43  ? 23.70494  -1.85811  13.93562 1.000 37.50228  ? 986  GLY   A CA   1 
ATOM   532  C  C    . GLY   A 1 43  ? 24.89405  -1.07339  14.44652 1.000 38.95551  ? 986  GLY   A C    1 
ATOM   533  O  O    . GLY   A 1 43  ? 24.73332  0.08813   14.81961 1.000 41.26542  ? 986  GLY   A O    1 
ATOM   534  H  H    . GLY   A 1 43  ? 24.29798  -3.71619  14.00316 1.000 38.52258  ? 986  GLY   A H    1 
ATOM   535  H  HA2  . GLY   A 1 43  ? 23.28790  -1.33318  13.23461 1.000 45.01802  ? 986  GLY   A HA2  1 
ATOM   536  H  HA3  . GLY   A 1 43  ? 23.08062  -1.95471  14.67169 1.000 45.01802  ? 986  GLY   A HA3  1 
ATOM   537  N  N    . GLY   A 1 44  ? 26.07667  -1.67699  14.46279 1.000 34.33872  ? 987  GLY   A N    1 
ATOM   538  C  CA   . GLY   A 1 44  ? 27.30148  -1.03232  14.89948 1.000 36.75615  ? 987  GLY   A CA   1 
ATOM   539  C  C    . GLY   A 1 44  ? 27.72232  -1.40151  16.30837 1.000 37.25091  ? 987  GLY   A C    1 
ATOM   540  O  O    . GLY   A 1 44  ? 26.99633  -2.03504  17.08361 1.000 37.70360  ? 987  GLY   A O    1 
ATOM   541  H  H    . GLY   A 1 44  ? 26.19683  -2.49181  14.21531 1.000 41.22174  ? 987  GLY   A H    1 
ATOM   542  H  HA2  . GLY   A 1 44  ? 28.02040  -1.28134  14.29778 1.000 44.12265  ? 987  GLY   A HA2  1 
ATOM   543  H  HA3  . GLY   A 1 44  ? 27.18049  -0.07048  14.86596 1.000 44.12265  ? 987  GLY   A HA3  1 
ATOM   544  N  N    . ILE   A 1 45  ? 28.92529  -0.93880  16.65211 1.000 34.67221  ? 988  ILE   A N    1 
ATOM   545  C  CA   . ILE   A 1 45  ? 29.56497  -1.22592  17.92761 1.000 41.61706  ? 988  ILE   A CA   1 
ATOM   546  C  C    . ILE   A 1 45  ? 29.48638  0.02215   18.78533 1.000 44.67846  ? 988  ILE   A C    1 
ATOM   547  O  O    . ILE   A 1 45  ? 30.12775  1.03091   18.46801 1.000 49.74978  ? 988  ILE   A O    1 
ATOM   548  C  CB   . ILE   A 1 45  ? 31.03020  -1.64997  17.75114 1.000 42.00369  ? 988  ILE   A CB   1 
ATOM   549  C  CG1  . ILE   A 1 45  ? 31.12167  -2.95471  16.95789 1.000 49.76190  ? 988  ILE   A CG1  1 
ATOM   550  C  CG2  . ILE   A 1 45  ? 31.64766  -1.85343  19.10707 1.000 40.90498  ? 988  ILE   A CG2  1 
ATOM   551  C  CD1  . ILE   A 1 45  ? 32.55661  -3.44062  16.64510 1.000 41.04652  ? 988  ILE   A CD1  1 
ATOM   552  H  H    . ILE   A 1 45  ? 29.40378  -0.43890  16.14148 1.000 41.62193  ? 988  ILE   A H    1 
ATOM   553  H  HA   . ILE   A 1 45  ? 29.07332  -1.93944  18.36358 1.000 49.95575  ? 988  ILE   A HA   1 
ATOM   554  H  HB   . ILE   A 1 45  ? 31.49947  -0.95442  17.26442 1.000 50.41970  ? 988  ILE   A HB   1 
ATOM   555  H  HG12 . ILE   A 1 45  ? 30.68435  -3.65406  17.46833 1.000 59.72956  ? 988  ILE   A HG12 1 
ATOM   556  H  HG13 . ILE   A 1 45  ? 30.66751  -2.82941  16.10999 1.000 59.72956  ? 988  ILE   A HG13 1 
ATOM   557  H  HG21 . ILE   A 1 45  ? 32.47077  -2.35677  19.00694 1.000 49.10126  ? 988  ILE   A HG21 1 
ATOM   558  H  HG22 . ILE   A 1 45  ? 31.83541  -0.98746  19.50173 1.000 49.10126  ? 988  ILE   A HG22 1 
ATOM   559  H  HG23 . ILE   A 1 45  ? 31.02581  -2.34423  19.66682 1.000 49.10126  ? 988  ILE   A HG23 1 
ATOM   560  H  HD11 . ILE   A 1 45  ? 32.51940  -4.09647  15.93139 1.000 49.27109  ? 988  ILE   A HD11 1 
ATOM   561  H  HD12 . ILE   A 1 45  ? 33.09393  -2.68163  16.36919 1.000 49.27109  ? 988  ILE   A HD12 1 
ATOM   562  H  HD13 . ILE   A 1 45  ? 32.93532  -3.84135  17.44316 1.000 49.27109  ? 988  ILE   A HD13 1 
ATOM   563  N  N    . PHE   A 1 46  ? 28.73712  -0.03941  19.87754 1.000 49.07915  ? 989  PHE   A N    1 
ATOM   564  C  CA   . PHE   A 1 46  ? 28.59143  1.11705   20.75045 1.000 44.83244  ? 989  PHE   A CA   1 
ATOM   565  C  C    . PHE   A 1 46  ? 28.00157  0.63827   22.05880 1.000 44.08263  ? 989  PHE   A C    1 
ATOM   566  O  O    . PHE   A 1 46  ? 27.42900  -0.44994  22.13875 1.000 41.32612  ? 989  PHE   A O    1 
ATOM   567  C  CB   . PHE   A 1 46  ? 27.69311  2.18768   20.13438 1.000 43.04133  ? 989  PHE   A CB   1 
ATOM   568  C  CG   . PHE   A 1 46  ? 26.29856  1.71085   19.90614 1.000 47.28112  ? 989  PHE   A CG   1 
ATOM   569  C  CD1  . PHE   A 1 46  ? 25.99885  0.89406   18.80786 1.000 45.26695  ? 989  PHE   A CD1  1 
ATOM   570  C  CD2  . PHE   A 1 46  ? 25.29128  2.03073   20.81288 1.000 39.95678  ? 989  PHE   A CD2  1 
ATOM   571  C  CE1  . PHE   A 1 46  ? 24.69629  0.43195   18.60274 1.000 36.39582  ? 989  PHE   A CE1  1 
ATOM   572  C  CE2  . PHE   A 1 46  ? 23.99855  1.56684   20.63049 1.000 40.37875  ? 989  PHE   A CE2  1 
ATOM   573  C  CZ   . PHE   A 1 46  ? 23.69894  0.76323   19.52374 1.000 39.45484  ? 989  PHE   A CZ   1 
ATOM   574  H  H    . PHE   A 1 46  ? 28.30435  -0.73687  20.13417 1.000 58.91025  ? 989  PHE   A H    1 
ATOM   575  H  HA   . PHE   A 1 46  ? 29.46351  1.50850   20.91522 1.000 53.81420  ? 989  PHE   A HA   1 
ATOM   576  H  HB2  . PHE   A 1 46  ? 27.65537  2.95037   20.73251 1.000 51.66487  ? 989  PHE   A HB2  1 
ATOM   577  H  HB3  . PHE   A 1 46  ? 28.06262  2.45533   19.27838 1.000 51.66487  ? 989  PHE   A HB3  1 
ATOM   578  H  HD1  . PHE   A 1 46  ? 26.67181  0.65777   18.21105 1.000 54.33562  ? 989  PHE   A HD1  1 
ATOM   579  H  HD2  . PHE   A 1 46  ? 25.48873  2.56231   21.54999 1.000 47.96341  ? 989  PHE   A HD2  1 
ATOM   580  H  HE1  . PHE   A 1 46  ? 24.49504  -0.09100  17.86051 1.000 43.69026  ? 989  PHE   A HE1  1 
ATOM   581  H  HE2  . PHE   A 1 46  ? 23.33257  1.78832   21.24066 1.000 48.46978  ? 989  PHE   A HE2  1 
ATOM   582  H  HZ   . PHE   A 1 46  ? 22.83243  0.44858   19.40105 1.000 47.36109  ? 989  PHE   A HZ   1 
ATOM   583  N  N    . ASN   A 1 47  ? 28.17518  1.46423   23.08829 1.000 44.03098  ? 990  ASN   A N    1 
ATOM   584  C  CA   . ASN   A 1 47  ? 27.56107  1.26155   24.38442 1.000 40.63365  ? 990  ASN   A CA   1 
ATOM   585  C  C    . ASN   A 1 47  ? 26.54508  2.33516   24.72238 1.000 37.91623  ? 990  ASN   A C    1 
ATOM   586  O  O    . ASN   A 1 47  ? 25.77749  2.16000   25.65983 1.000 41.56359  ? 990  ASN   A O    1 
ATOM   587  C  CB   . ASN   A 1 47  ? 28.60884  1.27461   25.49882 1.000 51.16068  ? 990  ASN   A CB   1 
ATOM   588  C  CG   . ASN   A 1 47  ? 29.71941  0.32047   25.25518 1.000 51.60352  ? 990  ASN   A CG   1 
ATOM   589  O  OD1  . ASN   A 1 47  ? 29.50445  -0.77248  24.75579 1.000 58.26627  ? 990  ASN   A OD1  1 
ATOM   590  N  ND2  . ASN   A 1 47  ? 30.92890  0.72650   25.60249 1.000 58.92223  ? 990  ASN   A ND2  1 
ATOM   591  H  H    . ASN   A 1 47  ? 28.66233  2.17211   23.05371 1.000 52.85245  ? 990  ASN   A H    1 
ATOM   592  H  HA   . ASN   A 1 47  ? 27.13353  0.39086   24.38252 1.000 48.77566  ? 990  ASN   A HA   1 
ATOM   593  H  HB2  . ASN   A 1 47  ? 28.98784  2.16499   25.56575 1.000 61.40810  ? 990  ASN   A HB2  1 
ATOM   594  H  HB3  . ASN   A 1 47  ? 28.18298  1.03155   26.33576 1.000 61.40810  ? 990  ASN   A HB3  1 
ATOM   595  H  HD21 . ASN   A 1 47  ? 31.60663  0.21096   25.48210 1.000 70.72195  ? 990  ASN   A HD21 1 
ATOM   596  H  HD22 . ASN   A 1 47  ? 31.03782  1.50612   25.94879 1.000 70.72195  ? 990  ASN   A HD22 1 
ATOM   597  N  N    . ARG   A 1 48  ? 26.56447  3.44695   24.02119 1.000 43.11349  ? 991  ARG   A N    1 
ATOM   598  C  CA   . ARG   A 1 48  ? 25.72464  4.57693   24.36151 1.000 44.40306  ? 991  ARG   A CA   1 
ATOM   599  C  C    . ARG   A 1 48  ? 25.60058  5.41572   23.10570 1.000 45.43376  ? 991  ARG   A C    1 
ATOM   600  O  O    . ARG   A 1 48  ? 26.27682  5.17502   22.09933 1.000 42.19813  ? 991  ARG   A O    1 
ATOM   601  C  CB   . ARG   A 1 48  ? 26.31208  5.37776   25.52577 1.000 46.75445  ? 991  ARG   A CB   1 
ATOM   602  C  CG   . ARG   A 1 48  ? 27.66692  5.96946   25.24202 1.000 53.36053  ? 991  ARG   A CG   1 
ATOM   603  C  CD   . ARG   A 1 48  ? 28.44293  6.20658   26.53561 1.000 67.76299  ? 991  ARG   A CD   1 
ATOM   604  N  NE   . ARG   A 1 48  ? 29.64925  6.99888   26.32970 1.000 72.56208  ? 991  ARG   A NE   1 
ATOM   605  C  CZ   . ARG   A 1 48  ? 29.66229  8.32028   26.20129 1.000 74.74807  ? 991  ARG   A CZ   1 
ATOM   606  N  NH1  . ARG   A 1 48  ? 28.54552  9.03177   26.23156 1.000 83.79974  ? 991  ARG   A NH1  1 
ATOM   607  N  NH2  . ARG   A 1 48  ? 30.82226  8.94195   26.02172 1.000 88.91277  ? 991  ARG   A NH2  1 
ATOM   608  H  H    . ARG   A 1 48  ? 27.06254  3.57640   23.33215 1.000 51.75147  ? 991  ARG   A H    1 
ATOM   609  H  HA   . ARG   A 1 48  ? 24.84219  4.28107   24.63474 1.000 53.29895  ? 991  ARG   A HA   1 
ATOM   610  H  HB2  . ARG   A 1 48  ? 25.70941  6.10827   25.73564 1.000 56.12062  ? 991  ARG   A HB2  1 
ATOM   611  H  HB3  . ARG   A 1 48  ? 26.40152  4.79068   26.29273 1.000 56.12062  ? 991  ARG   A HB3  1 
ATOM   612  H  HG2  . ARG   A 1 48  ? 28.17615  5.35901   24.68620 1.000 64.04791  ? 991  ARG   A HG2  1 
ATOM   613  H  HG3  . ARG   A 1 48  ? 27.55945  6.82006   24.78833 1.000 64.04791  ? 991  ARG   A HG3  1 
ATOM   614  H  HD2  . ARG   A 1 48  ? 27.87540  6.68136   27.16282 1.000 81.33086  ? 991  ARG   A HD2  1 
ATOM   615  H  HD3  . ARG   A 1 48  ? 28.70600  5.35063   26.90849 1.000 81.33086  ? 991  ARG   A HD3  1 
ATOM   616  H  HE   . ARG   A 1 48  ? 30.40112  6.58342   26.28877 1.000 87.08977  ? 991  ARG   A HE   1 
ATOM   617  H  HH11 . ARG   A 1 48  ? 27.78788  8.63859   26.33646 1.000 100.57497 ? 991  ARG   A HH11 1 
ATOM   618  H  HH12 . ARG   A 1 48  ? 28.57803  9.88692   26.14633 1.000 100.57497 ? 991  ARG   A HH12 1 
ATOM   619  H  HH21 . ARG   A 1 48  ? 31.55253  8.48886   25.98987 1.000 106.71060 ? 991  ARG   A HH21 1 
ATOM   620  H  HH22 . ARG   A 1 48  ? 30.84303  9.79754   25.93730 1.000 106.71060 ? 991  ARG   A HH22 1 
ATOM   621  N  N    . TYR   A 1 49  ? 24.72656  6.41716   23.19206 1.000 42.61679  ? 992  TYR   A N    1 
ATOM   622  C  CA   . TYR   A 1 49  ? 24.43619  7.30035   22.08834 1.000 47.17284  ? 992  TYR   A CA   1 
ATOM   623  C  C    . TYR   A 1 49  ? 24.84688  8.73608   22.40929 1.000 41.27317  ? 992  TYR   A C    1 
ATOM   624  O  O    . TYR   A 1 49  ? 24.91894  9.14816   23.57192 1.000 36.45092  ? 992  TYR   A O    1 
ATOM   625  C  CB   . TYR   A 1 49  ? 22.93711  7.29975   21.76571 1.000 43.35557  ? 992  TYR   A CB   1 
ATOM   626  C  CG   . TYR   A 1 49  ? 22.27428  5.97022   21.57395 1.000 36.51014  ? 992  TYR   A CG   1 
ATOM   627  C  CD1  . TYR   A 1 49  ? 22.42046  5.27102   20.39806 1.000 39.07429  ? 992  TYR   A CD1  1 
ATOM   628  C  CD2  . TYR   A 1 49  ? 21.44908  5.43856   22.55270 1.000 48.25254  ? 992  TYR   A CD2  1 
ATOM   629  C  CE1  . TYR   A 1 49  ? 21.78492  4.04985   20.19617 1.000 35.99345  ? 992  TYR   A CE1  1 
ATOM   630  C  CE2  . TYR   A 1 49  ? 20.80911  4.22598   22.37044 1.000 41.11870  ? 992  TYR   A CE2  1 
ATOM   631  C  CZ   . TYR   A 1 49  ? 20.98425  3.53476   21.18760 1.000 41.35212  ? 992  TYR   A CZ   1 
ATOM   632  O  OH   . TYR   A 1 49  ? 20.34827  2.32117   20.99387 1.000 42.09284  ? 992  TYR   A OH   1 
ATOM   633  H  H    . TYR   A 1 49  ? 24.28143  6.60237   23.90421 1.000 51.15542  ? 992  TYR   A H    1 
ATOM   634  H  HA   . TYR   A 1 49  ? 24.94398  6.99767   21.31929 1.000 56.62268  ? 992  TYR   A HA   1 
ATOM   635  H  HB2  . TYR   A 1 49  ? 22.47525  7.74066   22.49590 1.000 52.04196  ? 992  TYR   A HB2  1 
ATOM   636  H  HB3  . TYR   A 1 49  ? 22.80938  7.79802   20.94333 1.000 52.04196  ? 992  TYR   A HB3  1 
ATOM   637  H  HD1  . TYR   A 1 49  ? 22.95571  5.62227   19.72350 1.000 46.90442  ? 992  TYR   A HD1  1 
ATOM   638  H  HD2  . TYR   A 1 49  ? 21.32339  5.90596   23.34683 1.000 57.91832  ? 992  TYR   A HD2  1 
ATOM   639  H  HE1  . TYR   A 1 49  ? 21.90073  3.58659   19.39812 1.000 43.20741  ? 992  TYR   A HE1  1 
ATOM   640  H  HE2  . TYR   A 1 49  ? 20.26472  3.87855   23.03964 1.000 49.35771  ? 992  TYR   A HE2  1 
ATOM   641  H  HH   . TYR   A 1 49  ? 19.81434  2.17262   21.62510 1.000 50.52668  ? 992  TYR   A HH   1 
ATOM   642  N  N    . ASN   A 1 50  ? 25.06188  9.51115   21.36153 1.000 42.18548  ? 993  ASN   A N    1 
ATOM   643  C  CA   . ASN   A 1 50  ? 24.95640  10.95667  21.45001 1.000 45.41558  ? 993  ASN   A CA   1 
ATOM   644  C  C    . ASN   A 1 50  ? 23.55951  11.35293  20.99255 1.000 43.42879  ? 993  ASN   A C    1 
ATOM   645  O  O    . ASN   A 1 50  ? 23.25523  11.29112  19.79671 1.000 45.33196  ? 993  ASN   A O    1 
ATOM   646  C  CB   . ASN   A 1 50  ? 26.01048  11.65372  20.60796 1.000 47.67032  ? 993  ASN   A CB   1 
ATOM   647  C  CG   . ASN   A 1 50  ? 25.97794  13.16598  20.78273 1.000 50.65102  ? 993  ASN   A CG   1 
ATOM   648  O  OD1  . ASN   A 1 50  ? 25.48905  13.68962  21.78950 1.000 50.07313  ? 993  ASN   A OD1  1 
ATOM   649  N  ND2  . ASN   A 1 50  ? 26.46678  13.86881  19.78742 1.000 60.45641  ? 993  ASN   A ND2  1 
ATOM   650  H  H    . ASN   A 1 50  ? 25.27245  9.22050   20.58000 1.000 50.63785  ? 993  ASN   A H    1 
ATOM   651  H  HA   . ASN   A 1 50  ? 25.08707  11.22535  22.37285 1.000 54.51397  ? 993  ASN   A HA   1 
ATOM   652  H  HB2  . ASN   A 1 50  ? 26.88880  11.33765  20.87171 1.000 57.21966  ? 993  ASN   A HB2  1 
ATOM   653  H  HB3  . ASN   A 1 50  ? 25.85334  11.45403  19.67184 1.000 57.21966  ? 993  ASN   A HB3  1 
ATOM   654  H  HD21 . ASN   A 1 50  ? 26.47457  14.72769  19.83055 1.000 72.56297  ? 993  ASN   A HD21 1 
ATOM   655  H  HD22 . ASN   A 1 50  ? 26.77922  13.47033  19.09230 1.000 72.56297  ? 993  ASN   A HD22 1 
ATOM   656  N  N    . ILE   A 1 51  ? 22.71238  11.73905  21.93816 1.000 46.33646  ? 994  ILE   A N    1 
ATOM   657  C  CA   . ILE   A 1 51  ? 21.40064  12.28785  21.60639 1.000 40.64027  ? 994  ILE   A CA   1 
ATOM   658  C  C    . ILE   A 1 51  ? 21.58745  13.71976  21.14155 1.000 42.58699  ? 994  ILE   A C    1 
ATOM   659  O  O    . ILE   A 1 51  ? 22.16944  14.54241  21.85507 1.000 50.90293  ? 994  ILE   A O    1 
ATOM   660  C  CB   . ILE   A 1 51  ? 20.44190  12.23865  22.79774 1.000 45.00662  ? 994  ILE   A CB   1 
ATOM   661  C  CG1  . ILE   A 1 51  ? 20.27922  10.81046  23.28562 1.000 45.38092  ? 994  ILE   A CG1  1 
ATOM   662  C  CG2  . ILE   A 1 51  ? 19.09515  12.81219  22.39801 1.000 45.85552  ? 994  ILE   A CG2  1 
ATOM   663  C  CD1  . ILE   A 1 51  ? 19.79911  9.85683   22.23863 1.000 42.63376  ? 994  ILE   A CD1  1 
ATOM   664  H  H    . ILE   A 1 51  ? 22.87245  11.69404  22.78193 1.000 55.61903  ? 994  ILE   A H    1 
ATOM   665  H  HA   . ILE   A 1 51  ? 21.01808  11.76092  20.88744 1.000 48.78360  ? 994  ILE   A HA   1 
ATOM   666  H  HB   . ILE   A 1 51  ? 20.81358  12.77044  23.51882 1.000 54.02322  ? 994  ILE   A HB   1 
ATOM   667  H  HG12 . ILE   A 1 51  ? 21.13849  10.49113  23.60278 1.000 54.47238  ? 994  ILE   A HG12 1 
ATOM   668  H  HG13 . ILE   A 1 51  ? 19.63406  10.80157  24.00990 1.000 54.47238  ? 994  ILE   A HG13 1 
ATOM   669  H  HG21 . ILE   A 1 51  ? 18.43634  12.56638  23.06618 1.000 55.04190  ? 994  ILE   A HG21 1 
ATOM   670  H  HG22 . ILE   A 1 51  ? 19.16676  13.77802  22.34373 1.000 55.04190  ? 994  ILE   A HG22 1 
ATOM   671  H  HG23 . ILE   A 1 51  ? 18.84149  12.45026  21.53455 1.000 55.04190  ? 994  ILE   A HG23 1 
ATOM   672  H  HD11 . ILE   A 1 51  ? 19.70469  8.97582   22.63335 1.000 51.17578  ? 994  ILE   A HD11 1 
ATOM   673  H  HD12 . ILE   A 1 51  ? 18.94203  10.16225  21.90244 1.000 51.17578  ? 994  ILE   A HD12 1 
ATOM   674  H  HD13 . ILE   A 1 51  ? 20.44643  9.82825   21.51679 1.000 51.17578  ? 994  ILE   A HD13 1 
ATOM   675  N  N    . LEU   A 1 52  ? 21.09373  14.01101  19.94800 1.000 45.54818  ? 995  LEU   A N    1 
ATOM   676  C  CA   . LEU   A 1 52  ? 21.26479  15.29711  19.30343 1.000 43.29556  ? 995  LEU   A CA   1 
ATOM   677  C  C    . LEU   A 1 52  ? 20.00549  16.12918  19.36024 1.000 52.64229  ? 995  LEU   A C    1 
ATOM   678  O  O    . LEU   A 1 52  ? 20.08790  17.33517  19.59026 1.000 50.17602  ? 995  LEU   A O    1 
ATOM   679  C  CB   . LEU   A 1 52  ? 21.65022  15.11644  17.83409 1.000 45.14033  ? 995  LEU   A CB   1 
ATOM   680  C  CG   . LEU   A 1 52  ? 22.89366  14.26198  17.57084 1.000 43.92014  ? 995  LEU   A CG   1 
ATOM   681  C  CD1  . LEU   A 1 52  ? 23.06855  14.06022  16.12011 1.000 43.14308  ? 995  LEU   A CD1  1 
ATOM   682  C  CD2  . LEU   A 1 52  ? 24.09383  14.91894  18.19008 1.000 47.18520  ? 995  LEU   A CD2  1 
ATOM   683  H  H    . LEU   A 1 52  ? 20.63800  13.45618  19.47463 1.000 54.67309  ? 995  LEU   A H    1 
ATOM   684  H  HA   . LEU   A 1 52  ? 21.98517  15.77216  19.74647 1.000 51.96995  ? 995  LEU   A HA   1 
ATOM   685  H  HB2  . LEU   A 1 52  ? 20.90754  14.69302  17.37578 1.000 54.18367  ? 995  LEU   A HB2  1 
ATOM   686  H  HB3  . LEU   A 1 52  ? 21.81775  15.99329  17.45466 1.000 54.18367  ? 995  LEU   A HB3  1 
ATOM   687  H  HG   . LEU   A 1 52  ? 22.79473  13.38533  17.97406 1.000 52.71944  ? 995  LEU   A HG   1 
ATOM   688  H  HD11 . LEU   A 1 52  ? 23.86973  13.53480  15.96866 1.000 51.78697  ? 995  LEU   A HD11 1 
ATOM   689  H  HD12 . LEU   A 1 52  ? 22.29454  13.59131  15.77092 1.000 51.78697  ? 995  LEU   A HD12 1 
ATOM   690  H  HD13 . LEU   A 1 52  ? 23.15370  14.92498  15.68901 1.000 51.78697  ? 995  LEU   A HD13 1 
ATOM   691  H  HD21 . LEU   A 1 52  ? 24.89583  14.47590  17.87162 1.000 56.63751  ? 995  LEU   A HD21 1 
ATOM   692  H  HD22 . LEU   A 1 52  ? 24.10894  15.85445  17.93419 1.000 56.63751  ? 995  LEU   A HD22 1 
ATOM   693  H  HD23 . LEU   A 1 52  ? 24.03383  14.84089  19.15507 1.000 56.63751  ? 995  LEU   A HD23 1 
ATOM   694  N  N    . LYS   A 1 53  ? 18.84882  15.49558  19.14219 1.000 36.52109  ? 996  LYS   A N    1 
ATOM   695  C  CA   . LYS   A 1 53  ? 17.56483  16.17603  19.13582 1.000 44.34288  ? 996  LYS   A CA   1 
ATOM   696  C  C    . LYS   A 1 53  ? 16.47915  15.19241  19.56124 1.000 43.47167  ? 996  LYS   A C    1 
ATOM   697  O  O    . LYS   A 1 53  ? 16.53612  14.01344  19.21392 1.000 42.58201  ? 996  LYS   A O    1 
ATOM   698  C  CB   . LYS   A 1 53  ? 17.28999  16.73840  17.73360 1.000 43.76170  ? 996  LYS   A CB   1 
ATOM   699  C  CG   . LYS   A 1 53  ? 16.21023  17.76911  17.68162 1.000 53.55756  ? 996  LYS   A CG   1 
ATOM   700  C  CD   . LYS   A 1 53  ? 15.76476  18.08279  16.25760 1.000 51.32557  ? 996  LYS   A CD   1 
ATOM   701  C  CE   . LYS   A 1 53  ? 16.76573  18.91085  15.51810 1.000 61.05753  ? 996  LYS   A CE   1 
ATOM   702  N  NZ   . LYS   A 1 53  ? 16.41543  19.06120  14.04883 1.000 65.02430  ? 996  LYS   A NZ   1 
ATOM   703  H  H    . LYS   A 1 53  ? 18.78683  14.65099  18.99243 1.000 43.84059  ? 996  LYS   A H    1 
ATOM   704  H  HA   . LYS   A 1 53  ? 17.55049  16.90555  19.77495 1.000 53.22673  ? 996  LYS   A HA   1 
ATOM   705  H  HB2  . LYS   A 1 53  ? 18.10327  17.14871  17.40025 1.000 52.52932  ? 996  LYS   A HB2  1 
ATOM   706  H  HB3  . LYS   A 1 53  ? 17.02550  16.00721  17.15368 1.000 52.52932  ? 996  LYS   A HB3  1 
ATOM   707  H  HG2  . LYS   A 1 53  ? 15.43897  17.44494  18.17251 1.000 64.28435  ? 996  LYS   A HG2  1 
ATOM   708  H  HG3  . LYS   A 1 53  ? 16.53674  18.59037  18.08141 1.000 64.28435  ? 996  LYS   A HG3  1 
ATOM   709  H  HD2  . LYS   A 1 53  ? 15.64351  17.25190  15.77198 1.000 61.60596  ? 996  LYS   A HD2  1 
ATOM   710  H  HD3  . LYS   A 1 53  ? 14.92938  18.57492  16.28681 1.000 61.60596  ? 996  LYS   A HD3  1 
ATOM   711  H  HE2  . LYS   A 1 53  ? 16.79949  19.79646  15.91239 1.000 73.28431  ? 996  LYS   A HE2  1 
ATOM   712  H  HE3  . LYS   A 1 53  ? 17.63621  18.48722  15.57893 1.000 73.28431  ? 996  LYS   A HE3  1 
ATOM   713  H  HZ1  . LYS   A 1 53  ? 17.02071  19.57153  13.64226 1.000 78.04444  ? 996  LYS   A HZ1  1 
ATOM   714  H  HZ2  . LYS   A 1 53  ? 16.40033  18.26262  13.65624 1.000 78.04444  ? 996  LYS   A HZ2  1 
ATOM   715  H  HZ3  . LYS   A 1 53  ? 15.61450  19.43992  13.96407 1.000 78.04444  ? 996  LYS   A HZ3  1 
ATOM   716  N  N    . ILE   A 1 54  ? 15.48795  15.66801  20.31005 1.000 43.67435  ? 997  ILE   A N    1 
ATOM   717  C  CA   . ILE   A 1 54  ? 14.25327  14.91664  20.52435 1.000 41.14367  ? 997  ILE   A CA   1 
ATOM   718  C  C    . ILE   A 1 54  ? 13.08473  15.82850  20.19049 1.000 41.68831  ? 997  ILE   A C    1 
ATOM   719  O  O    . ILE   A 1 54  ? 13.01663  16.94780  20.70183 1.000 41.77049  ? 997  ILE   A O    1 
ATOM   720  C  CB   . ILE   A 1 54  ? 14.12350  14.40501  21.96608 1.000 39.68978  ? 997  ILE   A CB   1 
ATOM   721  C  CG1  . ILE   A 1 54  ? 15.27239  13.46642  22.32326 1.000 40.42326  ? 997  ILE   A CG1  1 
ATOM   722  C  CG2  . ILE   A 1 54  ? 12.83950  13.63441  22.12979 1.000 37.71983  ? 997  ILE   A CG2  1 
ATOM   723  C  CD1  . ILE   A 1 54  ? 15.19949  12.93305  23.73108 1.000 43.83267  ? 997  ILE   A CD1  1 
ATOM   724  H  H    . ILE   A 1 54  ? 15.50737  16.43022  20.70787 1.000 52.42449  ? 997  ILE   A H    1 
ATOM   725  H  HA   . ILE   A 1 54  ? 14.24231  14.15146  19.92830 1.000 49.38768  ? 997  ILE   A HA   1 
ATOM   726  H  HB   . ILE   A 1 54  ? 14.13929  15.18195  22.54661 1.000 47.64301  ? 997  ILE   A HB   1 
ATOM   727  H  HG12 . ILE   A 1 54  ? 15.25697  12.70886  21.71765 1.000 48.52319  ? 997  ILE   A HG12 1 
ATOM   728  H  HG13 . ILE   A 1 54  ? 16.10947  13.94779  22.23118 1.000 48.52319  ? 997  ILE   A HG13 1 
ATOM   729  H  HG21 . ILE   A 1 54  ? 12.71004  13.43244  23.06965 1.000 45.27907  ? 997  ILE   A HG21 1 
ATOM   730  H  HG22 . ILE   A 1 54  ? 12.10311  14.17467  21.80307 1.000 45.27907  ? 997  ILE   A HG22 1 
ATOM   731  H  HG23 . ILE   A 1 54  ? 12.89783  12.81149  21.61960 1.000 45.27907  ? 997  ILE   A HG23 1 
ATOM   732  H  HD11 . ILE   A 1 54  ? 16.04912  12.52381  23.95813 1.000 52.61448  ? 997  ILE   A HD11 1 
ATOM   733  H  HD12 . ILE   A 1 54  ? 15.01322  13.66682  24.33753 1.000 52.61448  ? 997  ILE   A HD12 1 
ATOM   734  H  HD13 . ILE   A 1 54  ? 14.49032  12.27326  23.78249 1.000 52.61448  ? 997  ILE   A HD13 1 
ATOM   735  N  N    . GLN   A 1 55  ? 12.17187  15.34491  19.35300 1.000 33.63777  ? 998  GLN   A N    1 
ATOM   736  C  CA   . GLN   A 1 55  ? 11.00050  16.08877  18.92453 1.000 38.30026  ? 998  GLN   A CA   1 
ATOM   737  C  C    . GLN   A 1 55  ? 9.71316   15.34465  19.25111 1.000 41.52238  ? 998  GLN   A C    1 
ATOM   738  O  O    . GLN   A 1 55  ? 9.62362   14.13372  19.07003 1.000 39.14180  ? 998  GLN   A O    1 
ATOM   739  C  CB   . GLN   A 1 55  ? 11.05533  16.32208  17.41930 1.000 43.28074  ? 998  GLN   A CB   1 
ATOM   740  C  CG   . GLN   A 1 55  ? 12.05630  17.35141  16.97123 1.000 35.67679  ? 998  GLN   A CG   1 
ATOM   741  C  CD   . GLN   A 1 55  ? 12.48889  17.11450  15.57190 1.000 41.41066  ? 998  GLN   A CD   1 
ATOM   742  O  OE1  . GLN   A 1 55  ? 13.00008  16.03781  15.23462 1.000 45.43307  ? 998  GLN   A OE1  1 
ATOM   743  N  NE2  . GLN   A 1 55  ? 12.25999  18.09712  14.72442 1.000 43.10813  ? 998  GLN   A NE2  1 
ATOM   744  H  H    . GLN   A 1 55  ? 12.21446  14.55799  19.00869 1.000 40.38060  ? 998  GLN   A H    1 
ATOM   745  H  HA   . GLN   A 1 55  ? 10.97878  16.93283  19.40203 1.000 45.97559  ? 998  GLN   A HA   1 
ATOM   746  H  HB2  . GLN   A 1 55  ? 11.28597  15.48484  16.98717 1.000 51.95216  ? 998  GLN   A HB2  1 
ATOM   747  H  HB3  . GLN   A 1 55  ? 10.18071  16.61862  17.12265 1.000 51.95216  ? 998  GLN   A HB3  1 
ATOM   748  H  HG2  . GLN   A 1 55  ? 11.65484  18.23299  17.02173 1.000 42.82743  ? 998  GLN   A HG2  1 
ATOM   749  H  HG3  . GLN   A 1 55  ? 12.83812  17.30961  17.54386 1.000 42.82743  ? 998  GLN   A HG3  1 
ATOM   750  H  HE21 . GLN   A 1 55  ? 11.88105  18.81976  14.99608 1.000 51.74504  ? 998  GLN   A HE21 1 
ATOM   751  H  HE22 . GLN   A 1 55  ? 12.48954  18.01582  13.89961 1.000 51.74504  ? 998  GLN   A HE22 1 
ATOM   752  N  N    . LYS   A 1 56  ? 8.69738   16.08652  19.67234 1.000 43.48353  ? 999  LYS   A N    1 
ATOM   753  C  CA   . LYS   A 1 56  ? 7.35923   15.52191  19.83766 1.000 40.32588  ? 999  LYS   A CA   1 
ATOM   754  C  C    . LYS   A 1 56  ? 6.60053   15.53901  18.52060 1.000 44.53765  ? 999  LYS   A C    1 
ATOM   755  O  O    . LYS   A 1 56  ? 6.56023   16.55553  17.82476 1.000 43.05362  ? 999  LYS   A O    1 
ATOM   756  C  CB   . LYS   A 1 56  ? 6.55842   16.32212  20.86515 1.000 44.16672  ? 999  LYS   A CB   1 
ATOM   757  C  CG   . LYS   A 1 56  ? 6.87946   16.02766  22.27354 1.000 45.21042  ? 999  LYS   A CG   1 
ATOM   758  C  CD   . LYS   A 1 56  ? 6.06408   16.89605  23.23553 1.000 62.60037  ? 999  LYS   A CD   1 
ATOM   759  C  CE   . LYS   A 1 56  ? 4.63570   16.39763  23.43410 1.000 59.11274  ? 999  LYS   A CE   1 
ATOM   760  N  NZ   . LYS   A 1 56  ? 4.52386   15.18993  24.31407 1.000 57.11100  ? 999  LYS   A NZ   1 
ATOM   761  H  H    . LYS   A 1 56  ? 8.75398   16.92151  19.87029 1.000 52.19551  ? 999  LYS   A H    1 
ATOM   762  H  HA   . LYS   A 1 56  ? 7.44799   14.60606  20.14463 1.000 48.40633  ? 999  LYS   A HA   1 
ATOM   763  H  HB2  . LYS   A 1 56  ? 6.72884   17.26585  20.71943 1.000 53.01534  ? 999  LYS   A HB2  1 
ATOM   764  H  HB3  . LYS   A 1 56  ? 5.61620   16.13131  20.73585 1.000 53.01534  ? 999  LYS   A HB3  1 
ATOM   765  H  HG2  . LYS   A 1 56  ? 6.67870   15.09716  22.45998 1.000 54.26778  ? 999  LYS   A HG2  1 
ATOM   766  H  HG3  . LYS   A 1 56  ? 7.82066   16.20191  22.43065 1.000 54.26778  ? 999  LYS   A HG3  1 
ATOM   767  H  HD2  . LYS   A 1 56  ? 6.50049   16.90077  24.10180 1.000 75.13572  ? 999  LYS   A HD2  1 
ATOM   768  H  HD3  . LYS   A 1 56  ? 6.01779   17.79832  22.88244 1.000 75.13572  ? 999  LYS   A HD3  1 
ATOM   769  H  HE2  . LYS   A 1 56  ? 4.11280   17.10644  23.84039 1.000 70.95056  ? 999  LYS   A HE2  1 
ATOM   770  H  HE3  . LYS   A 1 56  ? 4.26425   16.16572  22.56857 1.000 70.95056  ? 999  LYS   A HE3  1 
ATOM   771  H  HZ1  . LYS   A 1 56  ? 4.85929   15.36772  25.11905 1.000 68.54847  ? 999  LYS   A HZ1  1 
ATOM   772  H  HZ2  . LYS   A 1 56  ? 3.66980   14.95566  24.40235 1.000 68.54847  ? 999  LYS   A HZ2  1 
ATOM   773  H  HZ3  . LYS   A 1 56  ? 4.97435   14.51043  23.95710 1.000 68.54847  ? 999  LYS   A HZ3  1 
ATOM   774  N  N    . VAL   A 1 57  ? 5.91923   14.42676  18.22779 1.000 36.67119  ? 1000 VAL   A N    1 
ATOM   775  C  CA   . VAL   A 1 57  ? 5.15271   14.24889  17.00198 1.000 41.99166  ? 1000 VAL   A CA   1 
ATOM   776  C  C    . VAL   A 1 57  ? 3.66648   14.45950  17.29962 1.000 45.62776  ? 1000 VAL   A C    1 
ATOM   777  O  O    . VAL   A 1 57  ? 3.04928   13.67536  18.02870 1.000 37.81529  ? 1000 VAL   A O    1 
ATOM   778  C  CB   . VAL   A 1 57  ? 5.40472   12.85378  16.40535 1.000 42.97455  ? 1000 VAL   A CB   1 
ATOM   779  C  CG1  . VAL   A 1 57  ? 4.75628   12.73840  15.06746 1.000 43.31052  ? 1000 VAL   A CG1  1 
ATOM   780  C  CG2  . VAL   A 1 57  ? 6.92638   12.53719  16.29494 1.000 38.39152  ? 1000 VAL   A CG2  1 
ATOM   781  H  H    . VAL   A 1 57  ? 5.88819   13.74050  18.74517 1.000 44.02070  ? 1000 VAL   A H    1 
ATOM   782  H  HA   . VAL   A 1 57  ? 5.41786   14.92623  16.36026 1.000 50.40527  ? 1000 VAL   A HA   1 
ATOM   783  H  HB   . VAL   A 1 57  ? 5.01417   12.19799  17.00395 1.000 51.58473  ? 1000 VAL   A HB   1 
ATOM   784  H  HG11 . VAL   A 1 57  ? 5.04043   11.91066  14.64913 1.000 51.98790  ? 1000 VAL   A HG11 1 
ATOM   785  H  HG12 . VAL   A 1 57  ? 3.79312   12.73731  15.18238 1.000 51.98790  ? 1000 VAL   A HG12 1 
ATOM   786  H  HG13 . VAL   A 1 57  ? 5.02334   13.49394  14.52088 1.000 51.98790  ? 1000 VAL   A HG13 1 
ATOM   787  H  HG21 . VAL   A 1 57  ? 7.03897   11.67164  15.87180 1.000 46.08510  ? 1000 VAL   A HG21 1 
ATOM   788  H  HG22 . VAL   A 1 57  ? 7.35403   13.22467  15.76073 1.000 46.08510  ? 1000 VAL   A HG22 1 
ATOM   789  H  HG23 . VAL   A 1 57  ? 7.31135   12.52276  17.18516 1.000 46.08510  ? 1000 VAL   A HG23 1 
ATOM   790  N  N    . CYS   A 1 58  ? 3.08151   15.49711  16.70520 1.000 44.11766  ? 1001 CYS   A N    1 
ATOM   791  C  CA   . CYS   A 1 58  ? 1.72735   15.95686  17.01098 1.000 48.98940  ? 1001 CYS   A CA   1 
ATOM   792  C  C    . CYS   A 1 58  ? 0.92038   15.87980  15.72905 1.000 52.99882  ? 1001 CYS   A C    1 
ATOM   793  O  O    . CYS   A 1 58  ? 1.30168   16.47257  14.71358 1.000 51.60806  ? 1001 CYS   A O    1 
ATOM   794  C  CB   . CYS   A 1 58  ? 1.70357   17.39947  17.55165 1.000 48.10373  ? 1001 CYS   A CB   1 
ATOM   795  S  SG   . CYS   A 1 58  ? 2.56838   17.64110  19.14205 1.000 61.70403  ? 1001 CYS   A SG   1 
ATOM   796  H  H    . CYS   A 1 58  ? 3.46409   15.96976  16.09706 1.000 52.95647  ? 1001 CYS   A H    1 
ATOM   797  H  HA   . CYS   A 1 58  ? 1.34237   15.38110  17.69009 1.000 58.80255  ? 1001 CYS   A HA   1 
ATOM   798  H  HB2  . CYS   A 1 58  ? 2.12706   17.97890  16.89910 1.000 57.73975  ? 1001 CYS   A HB2  1 
ATOM   799  H  HB3  . CYS   A 1 58  ? 0.77920   17.66407  17.67986 1.000 57.73975  ? 1001 CYS   A HB3  1 
ATOM   800  H  HG   . CYS   A 1 58  ? 2.38222   18.76428  19.52128 1.000 74.06011  ? 1001 CYS   A HG   1 
ATOM   801  N  N    . ASN   A 1 59  ? -0.19567  15.16315  15.77823 1.000 46.84652  ? 1002 ASN   A N    1 
ATOM   802  C  CA   . ASN   A 1 59  ? -1.01008  14.96815  14.58543 1.000 47.98058  ? 1002 ASN   A CA   1 
ATOM   803  C  C    . ASN   A 1 59  ? -2.36195  14.47649  15.06416 1.000 52.36395  ? 1002 ASN   A C    1 
ATOM   804  O  O    . ASN   A 1 59  ? -2.46997  13.32681  15.50374 1.000 42.15111  ? 1002 ASN   A O    1 
ATOM   805  C  CB   . ASN   A 1 59  ? -0.37525  13.97680  13.64303 1.000 52.04105  ? 1002 ASN   A CB   1 
ATOM   806  C  CG   . ASN   A 1 59  ? -1.19017  13.77073  12.41242 1.000 49.15302  ? 1002 ASN   A CG   1 
ATOM   807  O  OD1  . ASN   A 1 59  ? -2.40852  13.59159  12.48116 1.000 48.66101  ? 1002 ASN   A OD1  1 
ATOM   808  N  ND2  . ASN   A 1 59  ? -0.53254  13.78681  11.27105 1.000 49.00084  ? 1002 ASN   A ND2  1 
ATOM   809  H  H    . ASN   A 1 59  ? -0.50158  14.78151  16.48560 1.000 56.23110  ? 1002 ASN   A H    1 
ATOM   810  H  HA   . ASN   A 1 59  ? -1.11227  15.80803  14.11103 1.000 57.59198  ? 1002 ASN   A HA   1 
ATOM   811  H  HB2  . ASN   A 1 59  ? 0.49778   14.30485  13.37640 1.000 62.46453  ? 1002 ASN   A HB2  1 
ATOM   812  H  HB3  . ASN   A 1 59  ? -0.28531  13.12219  14.09299 1.000 62.46453  ? 1002 ASN   A HB3  1 
ATOM   813  H  HD21 . ASN   A 1 59  ? -0.95416  13.67287  10.53020 1.000 58.81629  ? 1002 ASN   A HD21 1 
ATOM   814  H  HD22 . ASN   A 1 59  ? 0.31840   13.91125  11.26679 1.000 58.81629  ? 1002 ASN   A HD22 1 
ATOM   815  N  N    . LYS   A 1 60  ? -3.37401  15.34226  14.94950 1.000 50.02777  ? 1003 LYS   A N    1 
ATOM   816  C  CA   . LYS   A 1 60  ? -4.65026  15.13530  15.62283 1.000 53.78475  ? 1003 LYS   A CA   1 
ATOM   817  C  C    . LYS   A 1 60  ? -5.40125  13.95333  15.03375 1.000 51.13427  ? 1003 LYS   A C    1 
ATOM   818  O  O    . LYS   A 1 60  ? -5.99155  13.15761  15.77069 1.000 56.84521  ? 1003 LYS   A O    1 
ATOM   819  C  CB   . LYS   A 1 60  ? -5.48282  16.41043  15.52031 1.000 57.95988  ? 1003 LYS   A CB   1 
ATOM   820  C  CG   . LYS   A 1 60  ? -6.72508  16.43864  16.38105 1.000 75.43424  ? 1003 LYS   A CG   1 
ATOM   821  C  CD   . LYS   A 1 60  ? -6.41408  16.28670  17.86952 1.000 105.21099 ? 1003 LYS   A CD   1 
ATOM   822  C  CE   . LYS   A 1 60  ? -7.43925  17.01725  18.72751 1.000 127.75405 ? 1003 LYS   A CE   1 
ATOM   823  N  NZ   . LYS   A 1 60  ? -8.81410  16.87334  18.17650 1.000 137.43502 ? 1003 LYS   A NZ   1 
ATOM   824  H  H    . LYS   A 1 60  ? -3.34399  16.06371  14.48236 1.000 60.04861  ? 1003 LYS   A H    1 
ATOM   825  H  HA   . LYS   A 1 60  ? -4.49246  14.94343  16.56048 1.000 64.55697  ? 1003 LYS   A HA   1 
ATOM   826  H  HB2  . LYS   A 1 60  ? -4.92834  17.16042  15.78669 1.000 69.56713  ? 1003 LYS   A HB2  1 
ATOM   827  H  HB3  . LYS   A 1 60  ? -5.76599  16.51799  14.59882 1.000 69.56713  ? 1003 LYS   A HB3  1 
ATOM   828  H  HG2  . LYS   A 1 60  ? -7.17896  17.28652  16.25456 1.000 90.53636  ? 1003 LYS   A HG2  1 
ATOM   829  H  HG3  . LYS   A 1 60  ? -7.30778  15.70829  16.12037 1.000 90.53636  ? 1003 LYS   A HG3  1 
ATOM   830  H  HD2  . LYS   A 1 60  ? -6.43086  15.34651  18.10755 1.000 126.26846 ? 1003 LYS   A HD2  1 
ATOM   831  H  HD3  . LYS   A 1 60  ? -5.53841  16.66036  18.05520 1.000 126.26846 ? 1003 LYS   A HD3  1 
ATOM   832  H  HE2  . LYS   A 1 60  ? -7.42974  16.64712  19.62407 1.000 153.32013 ? 1003 LYS   A HE2  1 
ATOM   833  H  HE3  . LYS   A 1 60  ? -7.21947  17.96159  18.75610 1.000 153.32013 ? 1003 LYS   A HE3  1 
ATOM   834  H  HZ1  . LYS   A 1 60  ? -9.41143  17.16354  18.76902 1.000 164.93730 ? 1003 LYS   A HZ1  1 
ATOM   835  H  HZ2  . LYS   A 1 60  ? -8.89384  17.34970  17.42895 1.000 164.93730 ? 1003 LYS   A HZ2  1 
ATOM   836  H  HZ3  . LYS   A 1 60  ? -8.98072  16.01846  17.99339 1.000 164.93730 ? 1003 LYS   A HZ3  1 
ATOM   837  N  N    . LYS   A 1 61  ? -5.40595  13.83274  13.70923 1.000 48.60049  ? 1004 LYS   A N    1 
ATOM   838  C  CA   . LYS   A 1 61  ? -6.03289  12.68663  13.06597 1.000 55.41930  ? 1004 LYS   A CA   1 
ATOM   839  C  C    . LYS   A 1 61  ? -5.38407  11.38859  13.51630 1.000 50.36329  ? 1004 LYS   A C    1 
ATOM   840  O  O    . LYS   A 1 61  ? -6.06748  10.48897  14.01482 1.000 49.99348  ? 1004 LYS   A O    1 
ATOM   841  C  CB   . LYS   A 1 61  ? -5.95866  12.82914  11.54302 1.000 60.43337  ? 1004 LYS   A CB   1 
ATOM   842  C  CG   . LYS   A 1 61  ? -6.86017  13.94289  11.00834 1.000 81.32143  ? 1004 LYS   A CG   1 
ATOM   843  C  CD   . LYS   A 1 61  ? -6.90567  13.95610  9.49014  1.000 95.76877  ? 1004 LYS   A CD   1 
ATOM   844  C  CE   . LYS   A 1 61  ? -7.88287  15.00622  8.96717  1.000 120.60160 ? 1004 LYS   A CE   1 
ATOM   845  N  NZ   . LYS   A 1 61  ? -7.85099  15.10329  7.47637  1.000 109.87274 ? 1004 LYS   A NZ   1 
ATOM   846  H  H    . LYS   A 1 61  ? -5.05489  14.39771  13.16411 1.000 58.33586  ? 1004 LYS   A H    1 
ATOM   847  H  HA   . LYS   A 1 61  ? -6.96929  12.66082  13.31773 1.000 66.51844  ? 1004 LYS   A HA   1 
ATOM   848  H  HB2  . LYS   A 1 61  ? -5.04517  13.03430  11.28934 1.000 72.53532  ? 1004 LYS   A HB2  1 
ATOM   849  H  HB3  . LYS   A 1 61  ? -6.23716  11.99486  11.13398 1.000 72.53532  ? 1004 LYS   A HB3  1 
ATOM   850  H  HG2  . LYS   A 1 61  ? -7.76280  13.80923  11.33742 1.000 97.60099  ? 1004 LYS   A HG2  1 
ATOM   851  H  HG3  . LYS   A 1 61  ? -6.52111  14.80058  11.30883 1.000 97.60099  ? 1004 LYS   A HG3  1 
ATOM   852  H  HD2  . LYS   A 1 61  ? -6.02318  14.16221  9.14426  1.000 114.93780 ? 1004 LYS   A HD2  1 
ATOM   853  H  HD3  . LYS   A 1 61  ? -7.19276  13.08664  9.16995  1.000 114.93780 ? 1004 LYS   A HD3  1 
ATOM   854  H  HE2  . LYS   A 1 61  ? -8.78351  14.76698  9.23646  1.000 144.73719 ? 1004 LYS   A HE2  1 
ATOM   855  H  HE3  . LYS   A 1 61  ? -7.64649  15.87302  9.33279  1.000 144.73719 ? 1004 LYS   A HE3  1 
ATOM   856  H  HZ1  . LYS   A 1 61  ? -8.40433  15.74372  7.20113  1.000 131.86256 ? 1004 LYS   A HZ1  1 
ATOM   857  H  HZ2  . LYS   A 1 61  ? -7.02673  15.29590  7.20143  1.000 131.86256 ? 1004 LYS   A HZ2  1 
ATOM   858  H  HZ3  . LYS   A 1 61  ? -8.10244  14.32956  7.11550  1.000 131.86256 ? 1004 LYS   A HZ3  1 
ATOM   859  N  N    . LEU   A 1 62  ? -4.05863  11.27429  13.37157 1.000 42.30738  ? 1005 LEU   A N    1 
ATOM   860  C  CA   . LEU   A 1 62  ? -3.41534  10.01397  13.73728 1.000 48.81378  ? 1005 LEU   A CA   1 
ATOM   861  C  C    . LEU   A 1 62  ? -3.57631  9.70775   15.21856 1.000 46.96121  ? 1005 LEU   A C    1 
ATOM   862  O  O    . LEU   A 1 62  ? -3.64214  8.54222   15.60141 1.000 46.45826  ? 1005 LEU   A O    1 
ATOM   863  C  CB   . LEU   A 1 62  ? -1.93660  10.02130  13.39013 1.000 40.47101  ? 1005 LEU   A CB   1 
ATOM   864  C  CG   . LEU   A 1 62  ? -1.62027  10.02251  11.91834 1.000 50.15442  ? 1005 LEU   A CG   1 
ATOM   865  C  CD1  . LEU   A 1 62  ? -0.13281  10.05801  11.80229 1.000 51.47905  ? 1005 LEU   A CD1  1 
ATOM   866  C  CD2  . LEU   A 1 62  ? -2.21237  8.79102   11.26394 1.000 58.99652  ? 1005 LEU   A CD2  1 
ATOM   867  H  H    A LEU   A 1 62  ? -3.53285  11.88728  13.07595 0.530 50.78413  ? 1005 LEU   A H    1 
ATOM   868  H  H    B LEU   A 1 62  ? -3.53285  11.88728  13.07595 0.470 50.78413  ? 1005 LEU   A H    1 
ATOM   869  H  HA   . LEU   A 1 62  ? -3.84071  9.31396   13.21772 1.000 58.59181  ? 1005 LEU   A HA   1 
ATOM   870  H  HB2  . LEU   A 1 62  ? -1.53734  10.81799  13.77325 1.000 48.58049  ? 1005 LEU   A HB2  1 
ATOM   871  H  HB3  . LEU   A 1 62  ? -1.52936  9.22886   13.77366 1.000 48.58049  ? 1005 LEU   A HB3  1 
ATOM   872  H  HG   . LEU   A 1 62  ? -2.00069  10.78593  11.45642 1.000 60.20059  ? 1005 LEU   A HG   1 
ATOM   873  H  HD11 . LEU   A 1 62  ? 0.11020   10.08310  10.86356 1.000 61.79014  ? 1005 LEU   A HD11 1 
ATOM   874  H  HD12 . LEU   A 1 62  ? 0.20017   10.85063  12.25147 1.000 61.79014  ? 1005 LEU   A HD12 1 
ATOM   875  H  HD13 . LEU   A 1 62  ? 0.23546   9.26282   12.21816 1.000 61.79014  ? 1005 LEU   A HD13 1 
ATOM   876  H  HD21 . LEU   A 1 62  ? -1.80029  8.66627   10.39473 1.000 70.81110  ? 1005 LEU   A HD21 1 
ATOM   877  H  HD22 . LEU   A 1 62  ? -2.03832  8.02003   11.82623 1.000 70.81110  ? 1005 LEU   A HD22 1 
ATOM   878  H  HD23 . LEU   A 1 62  ? -3.16874  8.91668   11.16165 1.000 70.81110  ? 1005 LEU   A HD23 1 
ATOM   879  N  N    . TRP   A 1 63  ? -3.63689  10.72863  16.06704 1.000 43.47035  ? 1006 TRP   A N    1 
ATOM   880  C  CA   . TRP   A 1 63  ? -3.85183  10.44387  17.47239 1.000 47.41736  ? 1006 TRP   A CA   1 
ATOM   881  C  C    . TRP   A 1 63  ? -5.24343  9.88131   17.70616 1.000 51.25968  ? 1006 TRP   A C    1 
ATOM   882  O  O    . TRP   A 1 63  ? -5.41239  8.93887   18.48652 1.000 44.31856  ? 1006 TRP   A O    1 
ATOM   883  C  CB   . TRP   A 1 63  ? -3.65007  11.69126  18.30654 1.000 42.23267  ? 1006 TRP   A CB   1 
ATOM   884  C  CG   . TRP   A 1 63  ? -3.91043  11.42870  19.71851 1.000 42.01994  ? 1006 TRP   A CG   1 
ATOM   885  C  CD1  . TRP   A 1 63  ? -4.96614  11.86123  20.43103 1.000 50.14515  ? 1006 TRP   A CD1  1 
ATOM   886  C  CD2  . TRP   A 1 63  ? -3.12021  10.63167  20.60796 1.000 42.31961  ? 1006 TRP   A CD2  1 
ATOM   887  N  NE1  . TRP   A 1 63  ? -4.88699  11.40912  21.72326 1.000 49.81137  ? 1006 TRP   A NE1  1 
ATOM   888  C  CE2  . TRP   A 1 63  ? -3.76096  10.64764  21.85806 1.000 42.32692  ? 1006 TRP   A CE2  1 
ATOM   889  C  CE3  . TRP   A 1 63  ? -1.92232  9.91872   20.47268 1.000 44.03495  ? 1006 TRP   A CE3  1 
ATOM   890  C  CZ2  . TRP   A 1 63  ? -3.25462  9.97895   22.97395 1.000 47.56403  ? 1006 TRP   A CZ2  1 
ATOM   891  C  CZ3  . TRP   A 1 63  ? -1.41099  9.25517   21.58630 1.000 46.12180  ? 1006 TRP   A CZ3  1 
ATOM   892  C  CH2  . TRP   A 1 63  ? -2.08163  9.28849   22.82027 1.000 48.07476  ? 1006 TRP   A CH2  1 
ATOM   893  H  H    . TRP   A 1 63  ? -3.55945  11.55976  15.86009 1.000 52.17970  ? 1006 TRP   A H    1 
ATOM   894  H  HA   . TRP   A 1 63  ? -3.19693  9.78659   17.75521 1.000 56.91610  ? 1006 TRP   A HA   1 
ATOM   895  H  HB2  . TRP   A 1 63  ? -2.73349  11.99515  18.21475 1.000 50.69448  ? 1006 TRP   A HB2  1 
ATOM   896  H  HB3  . TRP   A 1 63  ? -4.26045  12.38228  18.00516 1.000 50.69448  ? 1006 TRP   A HB3  1 
ATOM   897  H  HD1  . TRP   A 1 63  ? -5.65227  12.39156  20.09504 1.000 60.18946  ? 1006 TRP   A HD1  1 
ATOM   898  H  HE1  . TRP   A 1 63  ? -5.45413  11.57763  22.34740 1.000 59.78892  ? 1006 TRP   A HE1  1 
ATOM   899  H  HE3  . TRP   A 1 63  ? -1.47736  9.88876   19.65658 1.000 52.85721  ? 1006 TRP   A HE3  1 
ATOM   900  H  HZ2  . TRP   A 1 63  ? -3.69734  10.00143  23.79150 1.000 57.09211  ? 1006 TRP   A HZ2  1 
ATOM   901  H  HZ3  . TRP   A 1 63  ? -0.61333  8.78290   21.51144 1.000 55.36143  ? 1006 TRP   A HZ3  1 
ATOM   902  H  HH2  . TRP   A 1 63  ? -1.72219  8.83288   23.54698 1.000 57.70499  ? 1006 TRP   A HH2  1 
ATOM   903  N  N    . GLU   A 1 64  ? -6.25125  10.44657  17.04538 1.000 48.69024  ? 1007 GLU   A N    1 
ATOM   904  C  CA   . GLU   A 1 64  ? -7.60266  9.93673   17.22553 1.000 48.24484  ? 1007 GLU   A CA   1 
ATOM   905  C  C    . GLU   A 1 64  ? -7.75390  8.54548   16.64762 1.000 44.15722  ? 1007 GLU   A C    1 
ATOM   906  O  O    . GLU   A 1 64  ? -8.50731  7.72924   17.18523 1.000 46.01035  ? 1007 GLU   A O    1 
ATOM   907  C  CB   . GLU   A 1 64  ? -8.58543  10.91085  16.60669 1.000 49.05318  ? 1007 GLU   A CB   1 
ATOM   908  C  CG   . GLU   A 1 64  ? -8.58559  12.22563  17.38884 1.000 63.52713  ? 1007 GLU   A CG   1 
ATOM   909  C  CD   . GLU   A 1 64  ? -9.48740  13.30045  16.80768 1.000 86.68230  ? 1007 GLU   A CD   1 
ATOM   910  O  OE1  . GLU   A 1 64  ? -9.99416  13.14993  15.67456 1.000 77.03822  ? 1007 GLU   A OE1  1 
ATOM   911  O  OE2  . GLU   A 1 64  ? -9.68296  14.31691  17.50080 1.000 88.19560  ? 1007 GLU   A OE2  1 
ATOM   912  H  H    . GLU   A 1 64  ? -6.17969  11.10892  16.50153 1.000 58.44356  ? 1007 GLU   A H    1 
ATOM   913  H  HA   . GLU   A 1 64  ? -7.80873  9.86993   18.17104 1.000 57.90908  ? 1007 GLU   A HA   1 
ATOM   914  H  HB2  . GLU   A 1 64  ? -8.32876  11.09408  15.68939 1.000 58.87909  ? 1007 GLU   A HB2  1 
ATOM   915  H  HB3  . GLU   A 1 64  ? -9.47849  10.53309  16.63216 1.000 58.87909  ? 1007 GLU   A HB3  1 
ATOM   916  H  HG2  . GLU   A 1 64  ? -8.88695  12.04793  18.29356 1.000 76.24783  ? 1007 GLU   A HG2  1 
ATOM   917  H  HG3  . GLU   A 1 64  ? -7.68185  12.57768  17.40332 1.000 76.24783  ? 1007 GLU   A HG3  1 
ATOM   918  N  N    . ARG   A 1 65  ? -7.05848  8.25998   15.55652 1.000 41.59467  ? 1008 ARG   A N    1 
ATOM   919  C  CA   . ARG   A 1 65  ? -7.05417  6.91476   14.99970 1.000 44.46358  ? 1008 ARG   A CA   1 
ATOM   920  C  C    . ARG   A 1 65  ? -6.47870  5.92734   16.00125 1.000 44.59041  ? 1008 ARG   A C    1 
ATOM   921  O  O    . ARG   A 1 65  ? -6.98439  4.81200   16.14242 1.000 39.38191  ? 1008 ARG   A O    1 
ATOM   922  C  CB   . ARG   A 1 65  ? -6.26041  6.95495   13.69566 1.000 46.29445  ? 1008 ARG   A CB   1 
ATOM   923  C  CG   . ARG   A 1 65  ? -5.74082  5.65566   13.12287 1.000 54.82562  ? 1008 ARG   A CG   1 
ATOM   924  C  CD   . ARG   A 1 65  ? -4.94446  5.94363   11.80207 1.000 65.50242  ? 1008 ARG   A CD   1 
ATOM   925  N  NE   . ARG   A 1 65  ? -4.49618  4.75652   11.06623 1.000 67.02512  ? 1008 ARG   A NE   1 
ATOM   926  C  CZ   . ARG   A 1 65  ? -3.27437  4.21766   11.11053 1.000 73.94992  ? 1008 ARG   A CZ   1 
ATOM   927  N  NH1  . ARG   A 1 65  ? -2.30423  4.72531   11.86774 1.000 66.51095  ? 1008 ARG   A NH1  1 
ATOM   928  N  NH2  . ARG   A 1 65  ? -3.02088  3.12975   10.38132 1.000 68.35256  ? 1008 ARG   A NH2  1 
ATOM   929  H  H    . ARG   A 1 65  ? -6.58064  8.82514   15.11850 1.000 49.92888  ? 1008 ARG   A H    1 
ATOM   930  H  HA   . ARG   A 1 65  ? -7.95205  6.60885   14.79689 1.000 53.37157  ? 1008 ARG   A HA   1 
ATOM   931  H  HB2  . ARG   A 1 65  ? -6.83264  7.34540   13.01669 1.000 55.56862  ? 1008 ARG   A HB2  1 
ATOM   932  H  HB3  . ARG   A 1 65  ? -5.48582  7.52022   13.84187 1.000 55.56862  ? 1008 ARG   A HB3  1 
ATOM   933  H  HG2  . ARG   A 1 65  ? -5.14610  5.23025   13.76024 1.000 65.80602  ? 1008 ARG   A HG2  1 
ATOM   934  H  HG3  . ARG   A 1 65  ? -6.48376  5.06660   12.91803 1.000 65.80602  ? 1008 ARG   A HG3  1 
ATOM   935  H  HD2  . ARG   A 1 65  ? -5.51455  6.45420   11.20606 1.000 78.61819  ? 1008 ARG   A HD2  1 
ATOM   936  H  HD3  . ARG   A 1 65  ? -4.15408  6.45885   12.02736 1.000 78.61819  ? 1008 ARG   A HD3  1 
ATOM   937  H  HE   . ARG   A 1 65  ? -5.07388  4.37131   10.55880 1.000 80.44542  ? 1008 ARG   A HE   1 
ATOM   938  H  HH11 . ARG   A 1 65  ? -2.45437  5.42207   12.34896 1.000 79.82841  ? 1008 ARG   A HH11 1 
ATOM   939  H  HH12 . ARG   A 1 65  ? -1.52737  4.35648   11.87568 1.000 79.82841  ? 1008 ARG   A HH12 1 
ATOM   940  H  HH21 . ARG   A 1 65  ? -3.63936  2.78601   9.89253  1.000 82.03835  ? 1008 ARG   A HH21 1 
ATOM   941  H  HH22 . ARG   A 1 65  ? -2.23898  2.77214   10.40002 1.000 82.03835  ? 1008 ARG   A HH22 1 
ATOM   942  N  N    . TYR   A 1 66  ? -5.44332  6.34385   16.73696 1.000 41.33904  ? 1009 TYR   A N    1 
ATOM   943  C  CA   . TYR   A 1 66  ? -4.82497  5.47368   17.72297 1.000 42.66546  ? 1009 TYR   A CA   1 
ATOM   944  C  C    . TYR   A 1 66  ? -5.73339  5.27423   18.92456 1.000 44.22558  ? 1009 TYR   A C    1 
ATOM   945  O  O    . TYR   A 1 66  ? -5.86781  4.15500   19.42746 1.000 35.24410  ? 1009 TYR   A O    1 
ATOM   946  C  CB   . TYR   A 1 66  ? -3.47969  6.04190   18.18605 1.000 39.99764  ? 1009 TYR   A CB   1 
ATOM   947  C  CG   . TYR   A 1 66  ? -2.90665  5.29847   19.38088 1.000 38.70888  ? 1009 TYR   A CG   1 
ATOM   948  C  CD1  . TYR   A 1 66  ? -2.28663  4.06007   19.22029 1.000 40.81035  ? 1009 TYR   A CD1  1 
ATOM   949  C  CD2  . TYR   A 1 66  ? -3.04376  5.79458   20.67830 1.000 39.57000  ? 1009 TYR   A CD2  1 
ATOM   950  C  CE1  . TYR   A 1 66  ? -1.78243  3.36089   20.30554 1.000 35.61182  ? 1009 TYR   A CE1  1 
ATOM   951  C  CE2  . TYR   A 1 66  ? -2.54120  5.10664   21.75609 1.000 43.97111  ? 1009 TYR   A CE2  1 
ATOM   952  C  CZ   . TYR   A 1 66  ? -1.92155  3.87793   21.54952 1.000 41.91092  ? 1009 TYR   A CZ   1 
ATOM   953  O  OH   . TYR   A 1 66  ? -1.43692  3.16464   22.59010 1.000 38.52714  ? 1009 TYR   A OH   1 
ATOM   954  H  H    . TYR   A 1 66  ? -5.08542  7.12381   16.68058 1.000 49.62212  ? 1009 TYR   A H    1 
ATOM   955  H  HA   . TYR   A 1 66  ? -4.66349  4.61534   17.30098 1.000 51.21383  ? 1009 TYR   A HA   1 
ATOM   956  H  HB2  . TYR   A 1 66  ? -2.84211  5.97665   17.45794 1.000 48.01244  ? 1009 TYR   A HB2  1 
ATOM   957  H  HB3  . TYR   A 1 66  ? -3.59979  6.97043   18.43965 1.000 48.01244  ? 1009 TYR   A HB3  1 
ATOM   958  H  HD1  . TYR   A 1 66  ? -2.20986  3.69593   18.36799 1.000 48.98770  ? 1009 TYR   A HD1  1 
ATOM   959  H  HD2  . TYR   A 1 66  ? -3.48207  6.60330   20.81529 1.000 47.49927  ? 1009 TYR   A HD2  1 
ATOM   960  H  HE1  . TYR   A 1 66  ? -1.35313  2.54538   20.18087 1.000 42.74946  ? 1009 TYR   A HE1  1 
ATOM   961  H  HE2  . TYR   A 1 66  ? -2.61430  5.45815   22.61400 1.000 52.78061  ? 1009 TYR   A HE2  1 
ATOM   962  H  HH   . TYR   A 1 66  ? -1.66757  3.52103   23.31494 1.000 46.24785  ? 1009 TYR   A HH   1 
ATOM   963  N  N    . THR   A 1 67  ? -6.31554  6.36461   19.44981 1.000 39.71484  ? 1010 THR   A N    1 
ATOM   964  C  CA   . THR   A 1 67  ? -7.13306  6.22380   20.65018 1.000 36.19224  ? 1010 THR   A CA   1 
ATOM   965  C  C    . THR   A 1 67  ? -8.43814  5.51174   20.33781 1.000 39.28278  ? 1010 THR   A C    1 
ATOM   966  O  O    . THR   A 1 67  ? -9.01946  4.88782   21.22233 1.000 44.53976  ? 1010 THR   A O    1 
ATOM   967  C  CB   . THR   A 1 67  ? -7.45283  7.57223   21.28827 1.000 41.76939  ? 1010 THR   A CB   1 
ATOM   968  O  OG1  . THR   A 1 67  ? -8.11010  8.41625   20.32942 1.000 45.66999  ? 1010 THR   A OG1  1 
ATOM   969  C  CG2  . THR   A 1 67  ? -6.18957  8.23570   21.78627 1.000 45.86832  ? 1010 THR   A CG2  1 
ATOM   970  H  H    . THR   A 1 67  ? -6.25178  7.16360   19.13811 1.000 47.67309  ? 1010 THR   A H    1 
ATOM   971  H  HA   . THR   A 1 67  ? -6.61607  5.71258   21.29226 1.000 43.44597  ? 1010 THR   A HA   1 
ATOM   972  H  HB   . THR   A 1 67  ? -8.04100  7.44351   22.04879 1.000 50.13854  ? 1010 THR   A HB   1 
ATOM   973  H  HG1  . THR   A 1 67  ? -8.24736  9.17554   20.66143 1.000 54.81927  ? 1010 THR   A HG1  1 
ATOM   974  H  HG21 . THR   A 1 67  ? -6.40509  9.07595   22.22035 1.000 55.05725  ? 1010 THR   A HG21 1 
ATOM   975  H  HG22 . THR   A 1 67  ? -5.74059  7.65831   22.42341 1.000 55.05725  ? 1010 THR   A HG22 1 
ATOM   976  H  HG23 . THR   A 1 67  ? -5.59109  8.40977   21.04302 1.000 55.05725  ? 1010 THR   A HG23 1 
ATOM   977  N  N    . HIS   A 1 68  ? -8.91605  5.59772   19.10103 1.000 39.21982  ? 1011 HIS   A N    1 
ATOM   978  C  CA   . HIS   A 1 68  ? -10.12075 4.86187   18.74926 1.000 43.66502  ? 1011 HIS   A CA   1 
ATOM   979  C  C    . HIS   A 1 68  ? -9.87061  3.35483   18.76211 1.000 41.50022  ? 1011 HIS   A C    1 
ATOM   980  O  O    . HIS   A 1 68  ? -10.68402 2.58857   19.29381 1.000 42.72686  ? 1011 HIS   A O    1 
ATOM   981  C  CB   . HIS   A 1 68  ? -10.62961 5.31035   17.38587 1.000 45.47254  ? 1011 HIS   A CB   1 
ATOM   982  C  CG   . HIS   A 1 68  ? -11.85851 4.58061   16.95896 1.000 50.69800  ? 1011 HIS   A CG   1 
ATOM   983  N  ND1  . HIS   A 1 68  ? -11.81564 3.34839   16.34347 1.000 52.35230  ? 1011 HIS   A ND1  1 
ATOM   984  C  CD2  . HIS   A 1 68  ? -13.16520 4.87450   17.12148 1.000 58.31446  ? 1011 HIS   A CD2  1 
ATOM   985  C  CE1  . HIS   A 1 68  ? -13.04358 2.92741   16.12085 1.000 57.07162  ? 1011 HIS   A CE1  1 
ATOM   986  N  NE2  . HIS   A 1 68  ? -13.88126 3.83758   16.57860 1.000 61.99723  ? 1011 HIS   A NE2  1 
ATOM   987  H  H    . HIS   A 1 68  ? -8.57082  6.06237   18.46501 1.000 47.07906  ? 1011 HIS   A H    1 
ATOM   988  H  HA   . HIS   A 1 68  ? -10.80930 5.05795   19.40375 1.000 52.41330  ? 1011 HIS   A HA   1 
ATOM   989  H  HB2  . HIS   A 1 68  ? -10.84012 6.25650   17.42319 1.000 54.58233  ? 1011 HIS   A HB2  1 
ATOM   990  H  HB3  . HIS   A 1 68  ? -9.93976  5.14984   16.72312 1.000 54.58233  ? 1011 HIS   A HB3  1 
ATOM   991  H  HD2  . HIS   A 1 68  ? -13.51457 5.63599   17.52518 1.000 69.99263  ? 1011 HIS   A HD2  1 
ATOM   992  H  HE1  . HIS   A 1 68  ? -13.27939 2.12638   15.71143 1.000 68.50122  ? 1011 HIS   A HE1  1 
ATOM   993  H  HE2  . HIS   A 1 68  ? -14.73912 3.78891   16.54256 1.000 74.41195  ? 1011 HIS   A HE2  1 
ATOM   994  N  N    . ARG   A 1 69  ? -8.75402  2.90755   18.19284 1.000 37.85640  ? 1012 ARG   A N    1 
ATOM   995  C  CA   . ARG   A 1 69  ? -8.41731  1.48906   18.27536 1.000 41.84227  ? 1012 ARG   A CA   1 
ATOM   996  C  C    . ARG   A 1 69  ? -8.08911  1.05948   19.70584 1.000 41.81432  ? 1012 ARG   A C    1 
ATOM   997  O  O    . ARG   A 1 69  ? -8.43193  -0.05790  20.10886 1.000 45.40748  ? 1012 ARG   A O    1 
ATOM   998  C  CB   . ARG   A 1 69  ? -7.25618  1.16413   17.33170 1.000 42.41285  ? 1012 ARG   A CB   1 
ATOM   999  C  CG   . ARG   A 1 69  ? -6.78080  -0.28987  17.36710 1.000 41.37512  ? 1012 ARG   A CG   1 
ATOM   1000 C  CD   . ARG   A 1 69  ? -7.84966  -1.26402  16.93331 1.000 36.72248  ? 1012 ARG   A CD   1 
ATOM   1001 N  NE   . ARG   A 1 69  ? -7.41324  -2.65007  17.02264 1.000 40.02479  ? 1012 ARG   A NE   1 
ATOM   1002 C  CZ   . ARG   A 1 69  ? -8.24676  -3.67878  17.08364 1.000 39.95340  ? 1012 ARG   A CZ   1 
ATOM   1003 N  NH1  . ARG   A 1 69  ? -9.55188  -3.50908  17.04889 1.000 43.83772  ? 1012 ARG   A NH1  1 
ATOM   1004 N  NH2  . ARG   A 1 69  ? -7.75591  -4.90399  17.19520 1.000 39.46003  ? 1012 ARG   A NH2  1 
ATOM   1005 H  H    . ARG   A 1 69  ? -8.18776  3.39178   17.76335 1.000 45.44296  ? 1012 ARG   A H    1 
ATOM   1006 H  HA   . ARG   A 1 69  ? -9.19003  0.97771   17.98843 1.000 50.22600  ? 1012 ARG   A HA   1 
ATOM   1007 H  HB2  . ARG   A 1 69  ? -7.53614  1.35642   16.42311 1.000 50.91069  ? 1012 ARG   A HB2  1 
ATOM   1008 H  HB3  . ARG   A 1 69  ? -6.50043  1.72300   17.57129 1.000 50.91069  ? 1012 ARG   A HB3  1 
ATOM   1009 H  HG2  . ARG   A 1 69  ? -6.02363  -0.39003  16.76914 1.000 49.66542  ? 1012 ARG   A HG2  1 
ATOM   1010 H  HG3  . ARG   A 1 69  ? -6.51976  -0.51561  18.27363 1.000 49.66542  ? 1012 ARG   A HG3  1 
ATOM   1011 H  HD2  . ARG   A 1 69  ? -8.62680  -1.15643  17.50373 1.000 44.08225  ? 1012 ARG   A HD2  1 
ATOM   1012 H  HD3  . ARG   A 1 69  ? -8.08779  -1.08295  16.01059 1.000 44.08225  ? 1012 ARG   A HD3  1 
ATOM   1013 H  HE   . ARG   A 1 69  ? -6.56837  -2.81009  17.03659 1.000 48.04502  ? 1012 ARG   A HE   1 
ATOM   1014 H  HH11 . ARG   A 1 69  ? -9.88097  -2.71708  16.98531 1.000 52.62054  ? 1012 ARG   A HH11 1 
ATOM   1015 H  HH12 . ARG   A 1 69  ? -10.07531 -4.19021  17.08977 1.000 52.62054  ? 1012 ARG   A HH12 1 
ATOM   1016 H  HH21 . ARG   A 1 69  ? -6.90509  -5.02509  17.22725 1.000 47.36731  ? 1012 ARG   A HH21 1 
ATOM   1017 H  HH22 . ARG   A 1 69  ? -8.28806  -5.57838  17.23556 1.000 47.36731  ? 1012 ARG   A HH22 1 
ATOM   1018 N  N    . ARG   A 1 70  ? -7.42339  1.91911   20.48620 1.000 40.63648  ? 1013 ARG   A N    1 
ATOM   1019 C  CA   . ARG   A 1 70  ? -7.10854  1.59597   21.87666 1.000 45.03932  ? 1013 ARG   A CA   1 
ATOM   1020 C  C    . ARG   A 1 70  ? -8.35430  1.22431   22.66280 1.000 43.97575  ? 1013 ARG   A C    1 
ATOM   1021 O  O    . ARG   A 1 70  ? -8.34616  0.26850   23.44367 1.000 41.22977  ? 1013 ARG   A O    1 
ATOM   1022 C  CB   . ARG   A 1 70  ? -6.42360  2.77534   22.56816 1.000 44.66954  ? 1013 ARG   A CB   1 
ATOM   1023 C  CG   . ARG   A 1 70  ? -6.04897  2.48501   23.99258 1.000 41.63692  ? 1013 ARG   A CG   1 
ATOM   1024 C  CD   . ARG   A 1 70  ? -5.09034  3.53168   24.58548 1.000 41.66165  ? 1013 ARG   A CD   1 
ATOM   1025 N  NE   . ARG   A 1 70  ? -5.76623  4.81083   24.73957 1.000 39.44364  ? 1013 ARG   A NE   1 
ATOM   1026 C  CZ   . ARG   A 1 70  ? -5.16707  5.95776   25.03159 1.000 47.28363  ? 1013 ARG   A CZ   1 
ATOM   1027 N  NH1  . ARG   A 1 70  ? -3.85260  6.03907   25.22119 1.000 45.24931  ? 1013 ARG   A NH1  1 
ATOM   1028 N  NH2  . ARG   A 1 70  ? -5.90185  7.04778   25.15183 1.000 36.08524  ? 1013 ARG   A NH2  1 
ATOM   1029 H  H    . ARG   A 1 70  ? -7.14480  2.69256   20.23368 1.000 48.77905  ? 1013 ARG   A H    1 
ATOM   1030 H  HA   . ARG   A 1 70  ? -6.50081  0.84005   21.86401 1.000 54.06246  ? 1013 ARG   A HA   1 
ATOM   1031 H  HB2  . ARG   A 1 70  ? -5.61218  2.99549   22.08439 1.000 53.61873  ? 1013 ARG   A HB2  1 
ATOM   1032 H  HB3  . ARG   A 1 70  ? -7.02723  3.53464   22.56646 1.000 53.61873  ? 1013 ARG   A HB3  1 
ATOM   1033 H  HG2  . ARG   A 1 70  ? -6.85312  2.47522   24.53493 1.000 49.97958  ? 1013 ARG   A HG2  1 
ATOM   1034 H  HG3  . ARG   A 1 70  ? -5.61038  1.62081   24.03393 1.000 49.97958  ? 1013 ARG   A HG3  1 
ATOM   1035 H  HD2  . ARG   A 1 70  ? -4.78516  3.23594   25.45743 1.000 50.00926  ? 1013 ARG   A HD2  1 
ATOM   1036 H  HD3  . ARG   A 1 70  ? -4.33260  3.65162   23.99189 1.000 50.00926  ? 1013 ARG   A HD3  1 
ATOM   1037 H  HE   . ARG   A 1 70  ? -6.61952  4.82441   24.63320 1.000 47.34765  ? 1013 ARG   A HE   1 
ATOM   1038 H  HH11 . ARG   A 1 70  ? -3.36426  5.33422   25.15547 1.000 54.31444  ? 1013 ARG   A HH11 1 
ATOM   1039 H  HH12 . ARG   A 1 70  ? -3.49134  6.79646   25.40946 1.000 54.31444  ? 1013 ARG   A HH12 1 
ATOM   1040 H  HH21 . ARG   A 1 70  ? -6.75370  7.00650   25.04118 1.000 43.31756  ? 1013 ARG   A HH21 1 
ATOM   1041 H  HH22 . ARG   A 1 70  ? -5.52869  7.79921   25.34081 1.000 43.31756  ? 1013 ARG   A HH22 1 
ATOM   1042 N  N    . LYS   A 1 71  ? -9.42015  2.01708   22.50006 1.000 44.77839  ? 1014 LYS   A N    1 
ATOM   1043 C  CA   . LYS   A 1 71  ? -10.70295 1.73389   23.14322 1.000 49.35244  ? 1014 LYS   A CA   1 
ATOM   1044 C  C    . LYS   A 1 71  ? -11.30346 0.41128   22.66231 1.000 43.63517  ? 1014 LYS   A C    1 
ATOM   1045 O  O    . LYS   A 1 71  ? -11.88724 -0.32794  23.45439 1.000 43.54448  ? 1014 LYS   A O    1 
ATOM   1046 C  CB   . LYS   A 1 71  ? -11.65681 2.89481   22.88034 1.000 41.78230  ? 1014 LYS   A CB   1 
ATOM   1047 C  CG   . LYS   A 1 71  ? -12.79968 3.08645   23.86070 1.000 57.07516  ? 1014 LYS   A CG   1 
ATOM   1048 C  CD   . LYS   A 1 71  ? -13.27605 4.55733   23.78337 1.000 71.89275  ? 1014 LYS   A CD   1 
ATOM   1049 C  CE   . LYS   A 1 71  ? -14.52127 4.85420   24.62119 1.000 83.87876  ? 1014 LYS   A CE   1 
ATOM   1050 N  NZ   . LYS   A 1 71  ? -15.79259 4.76511   23.83183 1.000 69.69816  ? 1014 LYS   A NZ   1 
ATOM   1051 H  H    . LYS   A 1 71  ? -9.42545  2.72972   22.01870 1.000 53.74934  ? 1014 LYS   A H    1 
ATOM   1052 H  HA   . LYS   A 1 71  ? -10.56880 1.65096   24.10032 1.000 59.23821  ? 1014 LYS   A HA   1 
ATOM   1053 H  HB2  . LYS   A 1 71  ? -11.13864 3.71478   22.88794 1.000 50.15404  ? 1014 LYS   A HB2  1 
ATOM   1054 H  HB3  . LYS   A 1 71  ? -12.05502 2.76211   22.00586 1.000 50.15404  ? 1014 LYS   A HB3  1 
ATOM   1055 H  HG2  . LYS   A 1 71  ? -13.53797 2.50167   23.62863 1.000 68.50547  ? 1014 LYS   A HG2  1 
ATOM   1056 H  HG3  . LYS   A 1 71  ? -12.49826 2.89805   24.76322 1.000 68.50547  ? 1014 LYS   A HG3  1 
ATOM   1057 H  HD2  . LYS   A 1 71  ? -12.56321 5.13283   24.10204 1.000 86.28657  ? 1014 LYS   A HD2  1 
ATOM   1058 H  HD3  . LYS   A 1 71  ? -13.48554 4.76883   22.86018 1.000 86.28657  ? 1014 LYS   A HD3  1 
ATOM   1059 H  HE2  . LYS   A 1 71  ? -14.57413 4.21200   25.34623 1.000 100.66978 ? 1014 LYS   A HE2  1 
ATOM   1060 H  HE3  . LYS   A 1 71  ? -14.45394 5.75339   24.97870 1.000 100.66978 ? 1014 LYS   A HE3  1 
ATOM   1061 H  HZ1  . LYS   A 1 71  ? -16.48219 5.01427   24.33627 1.000 83.65307  ? 1014 LYS   A HZ1  1 
ATOM   1062 H  HZ2  . LYS   A 1 71  ? -15.74735 5.29836   23.12070 1.000 83.65307  ? 1014 LYS   A HZ2  1 
ATOM   1063 H  HZ3  . LYS   A 1 71  ? -15.92266 3.92844   23.55766 1.000 83.65307  ? 1014 LYS   A HZ3  1 
ATOM   1064 N  N    . GLU   A 1 72  ? -11.16292 0.08545   21.37933 1.000 39.82136  ? 1015 GLU   A N    1 
ATOM   1065 C  CA   . GLU   A 1 72  ? -11.63131 -1.21521  20.90875 1.000 40.52588  ? 1015 GLU   A CA   1 
ATOM   1066 C  C    . GLU   A 1 72  ? -10.90281 -2.33985  21.64090 1.000 43.54871  ? 1015 GLU   A C    1 
ATOM   1067 O  O    . GLU   A 1 72  ? -11.52910 -3.24578  22.19569 1.000 46.05716  ? 1015 GLU   A O    1 
ATOM   1068 C  CB   . GLU   A 1 72  ? -11.42532 -1.34866  19.39073 1.000 53.22401  ? 1015 GLU   A CB   1 
ATOM   1069 C  CG   . GLU   A 1 72  ? -12.32993 -0.46890  18.49781 1.000 51.85360  ? 1015 GLU   A CG   1 
ATOM   1070 C  CD   . GLU   A 1 72  ? -12.07270 -0.66427  16.98452 1.000 56.95035  ? 1015 GLU   A CD   1 
ATOM   1071 O  OE1  . GLU   A 1 72  ? -11.10165 -1.35669  16.59633 1.000 52.26841  ? 1015 GLU   A OE1  1 
ATOM   1072 O  OE2  . GLU   A 1 72  ? -12.85791 -0.11461  16.18013 1.000 67.57658  ? 1015 GLU   A OE2  1 
ATOM   1073 H  H    . GLU   A 1 72  ? -10.80909 0.58595   20.77609 1.000 47.80091  ? 1015 GLU   A H    1 
ATOM   1074 H  HA   . GLU   A 1 72  ? -12.58250 -1.28558  21.08535 1.000 48.64633  ? 1015 GLU   A HA   1 
ATOM   1075 H  HB2  . GLU   A 1 72  ? -10.50688 -1.11100  19.18851 1.000 63.88409  ? 1015 GLU   A HB2  1 
ATOM   1076 H  HB3  . GLU   A 1 72  ? -11.59128 -2.27180  19.14340 1.000 63.88409  ? 1015 GLU   A HB3  1 
ATOM   1077 H  HG2  . GLU   A 1 72  ? -13.25730 -0.69266  18.67333 1.000 62.23960  ? 1015 GLU   A HG2  1 
ATOM   1078 H  HG3  . GLU   A 1 72  ? -12.16797 0.46383   18.70919 1.000 62.23960  ? 1015 GLU   A HG3  1 
ATOM   1079 N  N    . VAL   A 1 73  ? -9.56879  -2.28715  21.65097 1.000 42.08861  ? 1016 VAL   A N    1 
ATOM   1080 C  CA   . VAL   A 1 73  ? -8.76981  -3.33581  22.27020 1.000 39.86439  ? 1016 VAL   A CA   1 
ATOM   1081 C  C    . VAL   A 1 73  ? -9.06308  -3.41457  23.75494 1.000 41.97030  ? 1016 VAL   A C    1 
ATOM   1082 O  O    . VAL   A 1 73  ? -9.28265  -4.49071  24.31587 1.000 37.92969  ? 1016 VAL   A O    1 
ATOM   1083 C  CB   . VAL   A 1 73  ? -7.27717  -3.05707  22.00164 1.000 45.72551  ? 1016 VAL   A CB   1 
ATOM   1084 C  CG1  . VAL   A 1 73  ? -6.37565  -3.99377  22.81948 1.000 38.50053  ? 1016 VAL   A CG1  1 
ATOM   1085 C  CG2  . VAL   A 1 73  ? -7.03568  -3.14021  20.51612 1.000 35.66999  ? 1016 VAL   A CG2  1 
ATOM   1086 H  H    . VAL   A 1 73  ? -9.10391  -1.65204  21.30438 1.000 50.52161  ? 1016 VAL   A H    1 
ATOM   1087 H  HA   . VAL   A 1 73  ? -9.00441  -4.19293  21.88134 1.000 47.85255  ? 1016 VAL   A HA   1 
ATOM   1088 H  HB   . VAL   A 1 73  ? -7.03737  -2.16396  22.29445 1.000 54.88589  ? 1016 VAL   A HB   1 
ATOM   1089 H  HG11 . VAL   A 1 73  ? -5.48124  -3.97826  22.44440 1.000 46.21591  ? 1016 VAL   A HG11 1 
ATOM   1090 H  HG12 . VAL   A 1 73  ? -6.35385  -3.68730  23.73954 1.000 46.21591  ? 1016 VAL   A HG12 1 
ATOM   1091 H  HG13 . VAL   A 1 73  ? -6.73576  -4.89353  22.77899 1.000 46.21591  ? 1016 VAL   A HG13 1 
ATOM   1092 H  HG21 . VAL   A 1 73  ? -6.08986  -3.01325  20.34233 1.000 42.81926  ? 1016 VAL   A HG21 1 
ATOM   1093 H  HG22 . VAL   A 1 73  ? -7.31604  -4.01296  20.19895 1.000 42.81926  ? 1016 VAL   A HG22 1 
ATOM   1094 H  HG23 . VAL   A 1 73  ? -7.54936  -2.44666  20.07337 1.000 42.81926  ? 1016 VAL   A HG23 1 
ATOM   1095 N  N    . SER   A 1 74  ? -9.04366  -2.26503  24.41430 1.000 39.60115  ? 1017 SER   A N    1 
ATOM   1096 C  CA   . SER   A 1 74  ? -9.35376  -2.17762  25.83220 1.000 38.86255  ? 1017 SER   A CA   1 
ATOM   1097 C  C    . SER   A 1 74  ? -10.62501 -2.94082  26.17801 1.000 45.80009  ? 1017 SER   A C    1 
ATOM   1098 O  O    . SER   A 1 74  ? -10.65927 -3.74547  27.11944 1.000 45.70623  ? 1017 SER   A O    1 
ATOM   1099 C  CB   . SER   A 1 74  ? -9.48048  -0.69363  26.17462 1.000 42.07523  ? 1017 SER   A CB   1 
ATOM   1100 O  OG   . SER   A 1 74  ? -9.66203  -0.47260  27.54320 1.000 60.14991  ? 1017 SER   A OG   1 
ATOM   1101 H  H    . SER   A 1 74  ? -8.85053  -1.50659  24.05782 1.000 47.53665  ? 1017 SER   A H    1 
ATOM   1102 H  HA   . SER   A 1 74  ? -8.64621  -2.57591  26.36290 1.000 46.65034  ? 1017 SER   A HA   1 
ATOM   1103 H  HB2  . SER   A 1 74  ? -8.66964  -0.24146  25.89361 1.000 50.50555  ? 1017 SER   A HB2  1 
ATOM   1104 H  HB3  . SER   A 1 74  ? -10.24431 -0.33107  25.69920 1.000 50.50555  ? 1017 SER   A HB3  1 
ATOM   1105 H  HG   . SER   A 1 74  ? -10.47124 -0.57202  27.74542 1.000 72.19517  ? 1017 SER   A HG   1 
ATOM   1106 N  N    . GLU   A 1 75  ? -11.69446 -2.69452  25.43137 1.000 47.08892  ? 1018 GLU   A N    1 
ATOM   1107 C  CA   . GLU   A 1 75  ? -12.97630 -3.26915  25.81919 1.000 52.66690  ? 1018 GLU   A CA   1 
ATOM   1108 C  C    . GLU   A 1 75  ? -13.06314 -4.75426  25.52414 1.000 45.76524  ? 1018 GLU   A C    1 
ATOM   1109 O  O    . GLU   A 1 75  ? -13.84998 -5.43821  26.18040 1.000 42.22908  ? 1018 GLU   A O    1 
ATOM   1110 C  CB   . GLU   A 1 75  ? -14.10836 -2.51837  25.13417 1.000 53.02405  ? 1018 GLU   A CB   1 
ATOM   1111 C  CG   . GLU   A 1 75  ? -14.15909 -1.05429  25.58210 1.000 59.21082  ? 1018 GLU   A CG   1 
ATOM   1112 C  CD   . GLU   A 1 75  ? -15.44526 -0.37949  25.21824 1.000 78.11191  ? 1018 GLU   A CD   1 
ATOM   1113 O  OE1  . GLU   A 1 75  ? -16.32404 -1.06951  24.66346 1.000 83.43261  ? 1018 GLU   A OE1  1 
ATOM   1114 O  OE2  . GLU   A 1 75  ? -15.57882 0.83470   25.48897 1.000 77.68815  ? 1018 GLU   A OE2  1 
ATOM   1115 H  H    . GLU   A 1 75  ? -11.70504 -2.21365  24.71846 1.000 56.52198  ? 1018 GLU   A H    1 
ATOM   1116 H  HA   . GLU   A 1 75  ? -13.09025 -3.16299  26.77661 1.000 63.21556  ? 1018 GLU   A HA   1 
ATOM   1117 H  HB2  . GLU   A 1 75  ? -13.97308 -2.54025  24.17390 1.000 63.64414  ? 1018 GLU   A HB2  1 
ATOM   1118 H  HB3  . GLU   A 1 75  ? -14.95379 -2.93703  25.35973 1.000 63.64414  ? 1018 GLU   A HB3  1 
ATOM   1119 H  HG2  . GLU   A 1 75  ? -14.06284 -1.01560  26.54653 1.000 71.06825  ? 1018 GLU   A HG2  1 
ATOM   1120 H  HG3  . GLU   A 1 75  ? -13.43516 -0.56864  25.15670 1.000 71.06825  ? 1018 GLU   A HG3  1 
ATOM   1121 N  N    . GLU   A 1 76  ? -12.26381 -5.25912  24.58394 1.000 39.58994  ? 1019 GLU   A N    1 
ATOM   1122 C  CA   . GLU   A 1 76  ? -12.04604 -6.68405  24.36484 1.000 47.70903  ? 1019 GLU   A CA   1 
ATOM   1123 C  C    . GLU   A 1 76  ? -11.06147 -7.32038  25.35510 1.000 47.24615  ? 1019 GLU   A C    1 
ATOM   1124 O  O    . GLU   A 1 76  ? -10.72155 -8.49755  25.16496 1.000 40.38435  ? 1019 GLU   A O    1 
ATOM   1125 C  CB   . GLU   A 1 76  ? -11.52008 -6.92126  22.93712 1.000 49.80673  ? 1019 GLU   A CB   1 
ATOM   1126 C  CG   . GLU   A 1 76  ? -12.43020 -6.41808  21.80124 1.000 52.44280  ? 1019 GLU   A CG   1 
ATOM   1127 C  CD   . GLU   A 1 76  ? -11.83799 -6.66228  20.40205 1.000 51.00234  ? 1019 GLU   A CD   1 
ATOM   1128 O  OE1  . GLU   A 1 76  ? -10.75690 -7.26414  20.30878 1.000 49.29044  ? 1019 GLU   A OE1  1 
ATOM   1129 O  OE2  . GLU   A 1 76  ? -12.44935 -6.24565  19.39251 1.000 56.28804  ? 1019 GLU   A OE2  1 
ATOM   1130 H  H    . GLU   A 1 76  ? -11.81620 -4.77107  24.03526 1.000 47.52321  ? 1019 GLU   A H    1 
ATOM   1131 H  HA   . GLU   A 1 76  ? -12.90286 -7.12672  24.46884 1.000 57.26612  ? 1019 GLU   A HA   1 
ATOM   1132 H  HB2  . GLU   A 1 76  ? -10.66802 -6.46657  22.84680 1.000 59.78335  ? 1019 GLU   A HB2  1 
ATOM   1133 H  HB3  . GLU   A 1 76  ? -11.40186 -7.87568  22.81057 1.000 59.78335  ? 1019 GLU   A HB3  1 
ATOM   1134 H  HG2  . GLU   A 1 76  ? -13.28097 -6.88139  21.85058 1.000 62.94664  ? 1019 GLU   A HG2  1 
ATOM   1135 H  HG3  . GLU   A 1 76  ? -12.56582 -5.46332  21.90576 1.000 62.94664  ? 1019 GLU   A HG3  1 
ATOM   1136 N  N    . ASN   A 1 77  ? -10.59385 -6.60946  26.37944 1.000 40.25593  ? 1020 ASN   A N    1 
ATOM   1137 C  CA   . ASN   A 1 77  ? -9.55277  -7.16214  27.24632 1.000 40.43339  ? 1020 ASN   A CA   1 
ATOM   1138 C  C    . ASN   A 1 77  ? -9.70975  -6.59247  28.65414 1.000 43.52351  ? 1020 ASN   A C    1 
ATOM   1139 O  O    . ASN   A 1 77  ? -8.80267  -5.95077  29.20967 1.000 37.69945  ? 1020 ASN   A O    1 
ATOM   1140 C  CB   . ASN   A 1 77  ? -8.16931  -6.88198  26.66300 1.000 41.79093  ? 1020 ASN   A CB   1 
ATOM   1141 C  CG   . ASN   A 1 77  ? -7.06568  -7.71332  27.31783 1.000 39.15083  ? 1020 ASN   A CG   1 
ATOM   1142 O  OD1  . ASN   A 1 77  ? -7.23310  -8.90854  27.54021 1.000 40.81281  ? 1020 ASN   A OD1  1 
ATOM   1143 N  ND2  . ASN   A 1 77  ? -5.92295  -7.07398  27.63163 1.000 41.01370  ? 1020 ASN   A ND2  1 
ATOM   1144 H  H    . ASN   A 1 77  ? -10.85878 -5.81864  26.58925 1.000 48.32239  ? 1020 ASN   A H    1 
ATOM   1145 H  HA   . ASN   A 1 77  ? -9.67095  -8.12333  27.30143 1.000 48.53534  ? 1020 ASN   A HA   1 
ATOM   1146 H  HB2  . ASN   A 1 77  ? -8.17850  -7.09047  25.71572 1.000 50.16439  ? 1020 ASN   A HB2  1 
ATOM   1147 H  HB3  . ASN   A 1 77  ? -7.95565  -5.94497  26.79441 1.000 50.16439  ? 1020 ASN   A HB3  1 
ATOM   1148 H  HD21 . ASN   A 1 77  ? -5.27687  -7.50463  28.00138 1.000 49.23171  ? 1020 ASN   A HD21 1 
ATOM   1149 H  HD22 . ASN   A 1 77  ? -5.83918  -6.23499  27.46231 1.000 49.23171  ? 1020 ASN   A HD22 1 
ATOM   1150 N  N    . HIS   A 1 78  ? -10.87966 -6.85020  29.25080 1.000 41.60101  ? 1021 HIS   A N    1 
ATOM   1151 C  CA   . HIS   A 1 78  ? -11.28590 -6.30362  30.54692 1.000 43.78932  ? 1021 HIS   A CA   1 
ATOM   1152 C  C    . HIS   A 1 78  ? -10.75712 -4.89070  30.79937 1.000 44.81052  ? 1021 HIS   A C    1 
ATOM   1153 O  O    . HIS   A 1 78  ? -10.10978 -4.64208  31.81822 1.000 45.52241  ? 1021 HIS   A O    1 
ATOM   1154 C  CB   . HIS   A 1 78  ? -10.87238 -7.25247  31.69087 1.000 42.87844  ? 1021 HIS   A CB   1 
ATOM   1155 C  CG   . HIS   A 1 78  ? -9.49912  -7.83774  31.54592 1.000 41.90007  ? 1021 HIS   A CG   1 
ATOM   1156 N  ND1  . HIS   A 1 78  ? -9.27075  -9.02987  30.90288 1.000 38.30933  ? 1021 HIS   A ND1  1 
ATOM   1157 C  CD2  . HIS   A 1 78  ? -8.28342  -7.39057  31.94935 1.000 37.61017  ? 1021 HIS   A CD2  1 
ATOM   1158 C  CE1  . HIS   A 1 78  ? -7.97262  -9.29486  30.90816 1.000 43.64882  ? 1021 HIS   A CE1  1 
ATOM   1159 N  NE2  . HIS   A 1 78  ? -7.34876  -8.31093  31.53154 1.000 39.69813  ? 1021 HIS   A NE2  1 
ATOM   1160 H  H    . HIS   A 1 78  ? -11.48085 -7.36141  28.90898 1.000 49.93648  ? 1021 HIS   A H    1 
ATOM   1161 H  HA   . HIS   A 1 78  ? -12.25317 -6.23140  30.53816 1.000 52.56246  ? 1021 HIS   A HA   1 
ATOM   1162 H  HB2  . HIS   A 1 78  ? -10.89389 -6.75848  32.52539 1.000 51.46941  ? 1021 HIS   A HB2  1 
ATOM   1163 H  HB3  . HIS   A 1 78  ? -11.50278 -7.98890  31.72492 1.000 51.46941  ? 1021 HIS   A HB3  1 
ATOM   1164 H  HD2  . HIS   A 1 78  ? -8.11302  -6.60728  32.42087 1.000 45.14748  ? 1021 HIS   A HD2  1 
ATOM   1165 H  HE1  . HIS   A 1 78  ? -7.56911  -10.04573 30.53632 1.000 52.39386  ? 1021 HIS   A HE1  1 
ATOM   1166 H  HE2  . HIS   A 1 78  ? -6.49962  -8.25479  31.65568 1.000 47.65303  ? 1021 HIS   A HE2  1 
ATOM   1167 N  N    . ASN   A 1 79  ? -11.02451 -3.95978  29.87157 1.000 38.27701  ? 1022 ASN   A N    1 
ATOM   1168 C  CA   A ASN   A 1 79  ? -10.66386 -2.55213  30.05149 0.480 56.47329  ? 1022 ASN   A CA   1 
ATOM   1169 C  CA   B ASN   A 1 79  ? -10.66562 -2.54420  30.03119 0.520 53.94293  ? 1022 ASN   A CA   1 
ATOM   1170 C  C    . ASN   A 1 79  ? -9.16571  -2.36873  30.29714 1.000 40.73701  ? 1022 ASN   A C    1 
ATOM   1171 O  O    . ASN   A 1 79  ? -8.75001  -1.56505  31.12215 1.000 35.88494  ? 1022 ASN   A O    1 
ATOM   1172 C  CB   A ASN   A 1 79  ? -11.48665 -1.95170  31.18720 0.480 48.36357  ? 1022 ASN   A CB   1 
ATOM   1173 C  CB   B ASN   A 1 79  ? -11.51712 -1.90582  31.13481 0.520 44.88879  ? 1022 ASN   A CB   1 
ATOM   1174 C  CG   A ASN   A 1 79  ? -12.94456 -2.28885  31.06136 0.480 43.85117  ? 1022 ASN   A CG   1 
ATOM   1175 C  CG   B ASN   A 1 79  ? -11.35830 -0.38969  31.22068 0.520 37.72561  ? 1022 ASN   A CG   1 
ATOM   1176 O  OD1  A ASN   A 1 79  ? -13.50822 -2.16470  29.97410 0.480 44.43658  ? 1022 ASN   A OD1  1 
ATOM   1177 O  OD1  B ASN   A 1 79  ? -11.17410 0.30913   30.22016 0.520 31.78344  ? 1022 ASN   A OD1  1 
ATOM   1178 N  ND2  A ASN   A 1 79  ? -13.55838 -2.77212  32.15175 0.480 38.64187  ? 1022 ASN   A ND2  1 
ATOM   1179 N  ND2  B ASN   A 1 79  ? -11.43582 0.12106   32.43086 0.520 33.06308  ? 1022 ASN   A ND2  1 
ATOM   1180 H  H    A ASN   A 1 79  ? -11.41749 -4.12369  29.12438 0.480 45.94769  ? 1022 ASN   A H    1 
ATOM   1181 H  H    B ASN   A 1 79  ? -11.42078 -4.12767  29.12701 0.520 45.94769  ? 1022 ASN   A H    1 
ATOM   1182 H  HA   A ASN   A 1 79  ? -10.86044 -2.07178  29.23203 0.480 67.78322  ? 1022 ASN   A HA   1 
ATOM   1183 H  HA   B ASN   A 1 79  ? -10.84751 -2.07550  29.20165 0.520 64.74679  ? 1022 ASN   A HA   1 
ATOM   1184 H  HB2  A ASN   A 1 79  ? -11.16613 -2.30133  32.03332 0.480 58.05156  ? 1022 ASN   A HB2  1 
ATOM   1185 H  HB2  B ASN   A 1 79  ? -12.45187 -2.09759  30.96054 0.520 53.88182  ? 1022 ASN   A HB2  1 
ATOM   1186 H  HB3  A ASN   A 1 79  ? -11.39590 -0.98608  31.17149 0.480 58.05156  ? 1022 ASN   A HB3  1 
ATOM   1187 H  HB3  B ASN   A 1 79  ? -11.25527 -2.28125  31.99002 0.520 53.88182  ? 1022 ASN   A HB3  1 
ATOM   1188 H  HD21 A ASN   A 1 79  ? -14.39298 -2.97716  32.12002 0.480 46.38552  ? 1022 ASN   A HD21 1 
ATOM   1189 H  HD21 B ASN   A 1 79  ? -11.35433 0.96947   32.54555 0.520 39.69097  ? 1022 ASN   A HD21 1 
ATOM   1190 H  HD22 A ASN   A 1 79  ? -13.11733 -2.87691  32.88257 0.480 46.38552  ? 1022 ASN   A HD22 1 
ATOM   1191 H  HD22 B ASN   A 1 79  ? -11.56797 -0.39354  33.10711 0.520 39.69097  ? 1022 ASN   A HD22 1 
ATOM   1192 N  N    . HIS   A 1 80  ? -8.33490  -3.11391  29.56871 1.000 41.24874  ? 1023 HIS   A N    1 
ATOM   1193 C  CA   . HIS   A 1 80  ? -6.87744  -3.04770  29.72411 1.000 43.06710  ? 1023 HIS   A CA   1 
ATOM   1194 C  C    . HIS   A 1 80  ? -6.24608  -3.00696  28.34086 1.000 38.61218  ? 1023 HIS   A C    1 
ATOM   1195 O  O    . HIS   A 1 80  ? -6.09744  -4.04449  27.69366 1.000 39.91793  ? 1023 HIS   A O    1 
ATOM   1196 C  CB   . HIS   A 1 80  ? -6.37210  -4.24171  30.51164 1.000 37.88768  ? 1023 HIS   A CB   1 
ATOM   1197 C  CG   . HIS   A 1 80  ? -4.88687  -4.30430  30.66780 1.000 37.15690  ? 1023 HIS   A CG   1 
ATOM   1198 N  ND1  . HIS   A 1 80  ? -4.11545  -3.18913  30.92353 1.000 32.01169  ? 1023 HIS   A ND1  1 
ATOM   1199 C  CD2  . HIS   A 1 80  ? -4.03389  -5.35970  30.65670 1.000 36.19015  ? 1023 HIS   A CD2  1 
ATOM   1200 C  CE1  . HIS   A 1 80  ? -2.84712  -3.55450  31.03359 1.000 37.33639  ? 1023 HIS   A CE1  1 
ATOM   1201 N  NE2  . HIS   A 1 80  ? -2.77191  -4.86766  30.88552 1.000 35.98854  ? 1023 HIS   A NE2  1 
ATOM   1202 H  H    . HIS   A 1 80  ? -8.59276  -3.67387  28.96908 1.000 49.51376  ? 1023 HIS   A H    1 
ATOM   1203 H  HA   . HIS   A 1 80  ? -6.64359  -2.22830  30.18757 1.000 51.69579  ? 1023 HIS   A HA   1 
ATOM   1204 H  HB2  . HIS   A 1 80  ? -6.75806  -4.20997  31.40098 1.000 45.48049  ? 1023 HIS   A HB2  1 
ATOM   1205 H  HB3  . HIS   A 1 80  ? -6.65223  -5.05154  30.05711 1.000 45.48049  ? 1023 HIS   A HB3  1 
ATOM   1206 H  HD2  . HIS   A 1 80  ? -4.26151  -6.25093  30.51960 1.000 43.44346  ? 1023 HIS   A HD2  1 
ATOM   1207 H  HE1  . HIS   A 1 80  ? -2.12942  -2.98383  31.18894 1.000 44.81894  ? 1023 HIS   A HE1  1 
ATOM   1208 H  HE2  . HIS   A 1 80  ? -2.05159  -5.33575  30.92591 1.000 43.20152  ? 1023 HIS   A HE2  1 
ATOM   1209 N  N    . ALA   A 1 81  ? -5.86080  -1.81143  27.89590 1.000 40.05142  ? 1024 ALA   A N    1 
ATOM   1210 C  CA   . ALA   A 1 81  ? -5.17134  -1.66075  26.61993 1.000 39.81840  ? 1024 ALA   A CA   1 
ATOM   1211 C  C    . ALA   A 1 81  ? -3.78168  -2.32179  26.62181 1.000 34.91632  ? 1024 ALA   A C    1 
ATOM   1212 O  O    . ALA   A 1 81  ? -3.26166  -2.67191  25.56335 1.000 38.68946  ? 1024 ALA   A O    1 
ATOM   1213 C  CB   . ALA   A 1 81  ? -5.04431  -0.16107  26.29264 1.000 40.53871  ? 1024 ALA   A CB   1 
ATOM   1214 H  H    . ALA   A 1 81  ? -5.98743  -1.07146  28.31544 1.000 48.07698  ? 1024 ALA   A H    1 
ATOM   1215 H  HA   . ALA   A 1 81  ? -5.69156  -2.08708  25.92099 1.000 47.79735  ? 1024 ALA   A HA   1 
ATOM   1216 H  HB1  . ALA   A 1 81  ? -4.57121  -0.06029  25.45185 1.000 48.66172  ? 1024 ALA   A HB1  1 
ATOM   1217 H  HB2  . ALA   A 1 81  ? -5.93222  0.22277   26.22063 1.000 48.66172  ? 1024 ALA   A HB2  1 
ATOM   1218 H  HB3  . ALA   A 1 81  ? -4.55137  0.27679   27.00411 1.000 48.66172  ? 1024 ALA   A HB3  1 
ATOM   1219 N  N    . ASN   A 1 82  ? -3.16480  -2.48788  27.77287 1.000 29.48808  ? 1025 ASN   A N    1 
ATOM   1220 C  CA   . ASN   A 1 82  ? -1.79148  -2.99451  27.85787 1.000 37.20400  ? 1025 ASN   A CA   1 
ATOM   1221 C  C    . ASN   A 1 82  ? -0.85200  -2.12267  27.02606 1.000 33.45703  ? 1025 ASN   A C    1 
ATOM   1222 O  O    . ASN   A 1 82  ? -0.14596  -2.58630  26.12962 1.000 35.33106  ? 1025 ASN   A O    1 
ATOM   1223 C  CB   . ASN   A 1 82  ? -1.73081  -4.45646  27.41686 1.000 29.04135  ? 1025 ASN   A CB   1 
ATOM   1224 C  CG   . ASN   A 1 82  ? -0.54353  -5.18889  27.96096 1.000 38.93807  ? 1025 ASN   A CG   1 
ATOM   1225 O  OD1  . ASN   A 1 82  ? 0.22001   -4.68990  28.82344 1.000 40.15321  ? 1025 ASN   A OD1  1 
ATOM   1226 N  ND2  . ASN   A 1 82  ? -0.36505  -6.41318  27.45959 1.000 33.08774  ? 1025 ASN   A ND2  1 
ATOM   1227 H  H    . ASN   A 1 82  ? -3.51828  -2.31403  28.53736 1.000 35.40098  ? 1025 ASN   A H    1 
ATOM   1228 H  HA   . ASN   A 1 82  ? -1.49531  -2.94907  28.78043 1.000 44.66008  ? 1025 ASN   A HA   1 
ATOM   1229 H  HB2  . ASN   A 1 82  ? -2.52934  -4.91160  27.72685 1.000 34.86490  ? 1025 ASN   A HB2  1 
ATOM   1230 H  HB3  . ASN   A 1 82  ? -1.68404  -4.49092  26.44860 1.000 34.86490  ? 1025 ASN   A HB3  1 
ATOM   1231 H  HD21 . ASN   A 1 82  ? 0.29670   -6.89418  27.72477 1.000 39.72057  ? 1025 ASN   A HD21 1 
ATOM   1232 H  HD22 . ASN   A 1 82  ? -0.91183  -6.72089  26.87141 1.000 39.72057  ? 1025 ASN   A HD22 1 
ATOM   1233 N  N    . GLU   A 1 83  ? -0.85700  -0.83231  27.33426 1.000 37.12983  ? 1026 GLU   A N    1 
ATOM   1234 C  CA   . GLU   A 1 83  ? -0.14673  0.13873   26.51990 1.000 36.72563  ? 1026 GLU   A CA   1 
ATOM   1235 C  C    . GLU   A 1 83  ? 1.28373   0.29473   27.03194 1.000 36.48524  ? 1026 GLU   A C    1 
ATOM   1236 O  O    . GLU   A 1 83  ? 1.50964   0.45201   28.23496 1.000 39.18145  ? 1026 GLU   A O    1 
ATOM   1237 C  CB   . GLU   A 1 83  ? -0.89373  1.47317   26.52170 1.000 35.78452  ? 1026 GLU   A CB   1 
ATOM   1238 C  CG   . GLU   A 1 83  ? -0.09652  2.66196   26.01715 1.000 39.58337  ? 1026 GLU   A CG   1 
ATOM   1239 C  CD   . GLU   A 1 83  ? -0.97121  3.90071   25.89676 1.000 38.37503  ? 1026 GLU   A CD   1 
ATOM   1240 O  OE1  . GLU   A 1 83  ? -1.69405  4.00222   24.88136 1.000 35.27177  ? 1026 GLU   A OE1  1 
ATOM   1241 O  OE2  . GLU   A 1 83  ? -0.98257  4.73727   26.83366 1.000 42.87966  ? 1026 GLU   A OE2  1 
ATOM   1242 H  H    . GLU   A 1 83  ? -1.26581  -0.49560  28.01182 1.000 44.57107  ? 1026 GLU   A H    1 
ATOM   1243 H  HA   . GLU   A 1 83  ? -0.09285  -0.16822  25.60133 1.000 44.08603  ? 1026 GLU   A HA   1 
ATOM   1244 H  HB2  . GLU   A 1 83  ? -1.67574  1.38685   25.95433 1.000 42.95670  ? 1026 GLU   A HB2  1 
ATOM   1245 H  HB3  . GLU   A 1 83  ? -1.16444  1.67108   27.43189 1.000 42.95670  ? 1026 GLU   A HB3  1 
ATOM   1246 H  HG2  . GLU   A 1 83  ? 0.62303   2.85419   26.63859 1.000 47.51532  ? 1026 GLU   A HG2  1 
ATOM   1247 H  HG3  . GLU   A 1 83  ? 0.26717   2.45742   25.14148 1.000 47.51532  ? 1026 GLU   A HG3  1 
ATOM   1248 N  N    . ARG   A 1 84  ? 2.23840   0.22239   26.10795 1.000 33.30557  ? 1027 ARG   A N    1 
ATOM   1249 C  CA   . ARG   A 1 84  ? 3.65378   0.35148   26.38475 1.000 32.99874  ? 1027 ARG   A CA   1 
ATOM   1250 C  C    . ARG   A 1 84  ? 4.22440   1.51729   25.58335 1.000 39.38931  ? 1027 ARG   A C    1 
ATOM   1251 O  O    . ARG   A 1 84  ? 3.59681   2.02483   24.65604 1.000 41.07383  ? 1027 ARG   A O    1 
ATOM   1252 C  CB   . ARG   A 1 84  ? 4.41360   -0.92763  26.01866 1.000 40.79846  ? 1027 ARG   A CB   1 
ATOM   1253 C  CG   . ARG   A 1 84  ? 3.78903   -2.21655  26.53492 1.000 40.07753  ? 1027 ARG   A CG   1 
ATOM   1254 C  CD   . ARG   A 1 84  ? 3.84909   -2.28887  28.04854 1.000 39.36199  ? 1027 ARG   A CD   1 
ATOM   1255 N  NE   . ARG   A 1 84  ? 3.14325   -3.45997  28.54046 1.000 36.58020  ? 1027 ARG   A NE   1 
ATOM   1256 C  CZ   . ARG   A 1 84  ? 3.65304   -4.68483  28.56941 1.000 35.80644  ? 1027 ARG   A CZ   1 
ATOM   1257 N  NH1  . ARG   A 1 84  ? 4.88657   -4.93645  28.13991 1.000 37.56847  ? 1027 ARG   A NH1  1 
ATOM   1258 N  NH2  . ARG   A 1 84  ? 2.92144   -5.66949  29.06910 1.000 39.19329  ? 1027 ARG   A NH2  1 
ATOM   1259 H  H    . ARG   A 1 84  ? 2.07603   0.09238   25.27349 1.000 39.98196  ? 1027 ARG   A H    1 
ATOM   1260 H  HA   . ARG   A 1 84  ? 3.77261   0.52311   27.33202 1.000 39.61376  ? 1027 ARG   A HA   1 
ATOM   1261 H  HB2  . ARG   A 1 84  ? 4.45759   -0.99257  25.05184 1.000 48.97343  ? 1027 ARG   A HB2  1 
ATOM   1262 H  HB3  . ARG   A 1 84  ? 5.30853   -0.86960  26.38832 1.000 48.97343  ? 1027 ARG   A HB3  1 
ATOM   1263 H  HG2  . ARG   A 1 84  ? 2.85855   -2.25498  26.26355 1.000 48.10831  ? 1027 ARG   A HG2  1 
ATOM   1264 H  HG3  . ARG   A 1 84  ? 4.27180   -2.97606  26.17302 1.000 48.10831  ? 1027 ARG   A HG3  1 
ATOM   1265 H  HD2  . ARG   A 1 84  ? 4.77469   -2.34567  28.33302 1.000 47.24966  ? 1027 ARG   A HD2  1 
ATOM   1266 H  HD3  . ARG   A 1 84  ? 3.43371   -1.49809  28.42673 1.000 47.24966  ? 1027 ARG   A HD3  1 
ATOM   1267 H  HE   . ARG   A 1 84  ? 2.34153   -3.35204  28.83234 1.000 43.91152  ? 1027 ARG   A HE   1 
ATOM   1268 H  HH11 . ARG   A 1 84  ? 5.37415   -4.29742  27.83412 1.000 45.09745  ? 1027 ARG   A HH11 1 
ATOM   1269 H  HH12 . ARG   A 1 84  ? 5.19651   -5.73817  28.16802 1.000 45.09745  ? 1027 ARG   A HH12 1 
ATOM   1270 H  HH21 . ARG   A 1 84  ? 2.13092   -5.50920  29.36741 1.000 47.04722  ? 1027 ARG   A HH21 1 
ATOM   1271 H  HH22 . ARG   A 1 84  ? 3.23695   -6.46910  29.09521 1.000 47.04722  ? 1027 ARG   A HH22 1 
ATOM   1272 N  N    . MET   A 1 85  ? 5.44617   1.91074   25.94734 1.000 30.85662  ? 1028 MET   A N    1 
ATOM   1273 C  CA   . MET   A 1 85  ? 6.28227   2.80215   25.15278 1.000 38.25223  ? 1028 MET   A CA   1 
ATOM   1274 C  C    . MET   A 1 85  ? 7.44771   1.96467   24.64685 1.000 34.79665  ? 1028 MET   A C    1 
ATOM   1275 O  O    . MET   A 1 85  ? 8.18458   1.38384   25.44826 1.000 39.25548  ? 1028 MET   A O    1 
ATOM   1276 C  CB   . MET   A 1 85  ? 6.78504   3.98040   25.97890 1.000 34.20724  ? 1028 MET   A CB   1 
ATOM   1277 C  CG   . MET   A 1 85  ? 5.68716   4.93702   26.46327 1.000 31.68485  ? 1028 MET   A CG   1 
ATOM   1278 S  SD   . MET   A 1 85  ? 4.85534   5.80150   25.15122 1.000 38.93612  ? 1028 MET   A SD   1 
ATOM   1279 C  CE   . MET   A 1 85  ? 6.24080   6.55256   24.24018 1.000 39.41321  ? 1028 MET   A CE   1 
ATOM   1280 H  H    . MET   A 1 85  ? 5.82370   1.66304   26.67927 1.000 37.04322  ? 1028 MET   A H    1 
ATOM   1281 H  HA   . MET   A 1 85  ? 5.77510   3.17153   24.41303 1.000 45.91795  ? 1028 MET   A HA   1 
ATOM   1282 H  HB2  . MET   A 1 85  ? 7.23925   3.63540   26.76349 1.000 41.06396  ? 1028 MET   A HB2  1 
ATOM   1283 H  HB3  . MET   A 1 85  ? 7.40337   4.49530   25.43719 1.000 41.06396  ? 1028 MET   A HB3  1 
ATOM   1284 H  HG2  . MET   A 1 85  ? 5.02083   4.42633   26.94918 1.000 38.03709  ? 1028 MET   A HG2  1 
ATOM   1285 H  HG3  . MET   A 1 85  ? 6.08712   5.60060   27.04687 1.000 38.03709  ? 1028 MET   A HG3  1 
ATOM   1286 H  HE1  . MET   A 1 85  ? 5.88668   7.15259   23.56531 1.000 47.31112  ? 1028 MET   A HE1  1 
ATOM   1287 H  HE2  . MET   A 1 85  ? 6.79734   7.04630   24.86258 1.000 47.31112  ? 1028 MET   A HE2  1 
ATOM   1288 H  HE3  . MET   A 1 85  ? 6.75947   5.84966   23.81849 1.000 47.31112  ? 1028 MET   A HE3  1 
ATOM   1289 N  N    . LEU   A 1 86  ? 7.59190   1.88425   23.32619 1.000 27.49578  ? 1029 LEU   A N    1 
ATOM   1290 C  CA   . LEU   A 1 86  ? 8.52696   0.98961   22.66326 1.000 36.62998  ? 1029 LEU   A CA   1 
ATOM   1291 C  C    . LEU   A 1 86  ? 9.21652   1.70954   21.50947 1.000 37.34303  ? 1029 LEU   A C    1 
ATOM   1292 O  O    . LEU   A 1 86  ? 8.71453   2.70508   20.96663 1.000 32.39497  ? 1029 LEU   A O    1 
ATOM   1293 C  CB   . LEU   A 1 86  ? 7.79009   -0.24886  22.13404 1.000 35.08556  ? 1029 LEU   A CB   1 
ATOM   1294 C  CG   . LEU   A 1 86  ? 7.02889   -1.11348  23.14713 1.000 35.20440  ? 1029 LEU   A CG   1 
ATOM   1295 C  CD1  . LEU   A 1 86  ? 6.09660   -2.08752  22.46632 1.000 36.81634  ? 1029 LEU   A CD1  1 
ATOM   1296 C  CD2  . LEU   A 1 86  ? 8.03799   -1.88496  23.99549 1.000 37.69138  ? 1029 LEU   A CD2  1 
ATOM   1297 H  H    . LEU   A 1 86  ? 7.13829   2.35963   22.77134 1.000 33.01021  ? 1029 LEU   A H    1 
ATOM   1298 H  HA   . LEU   A 1 86  ? 9.21680   0.72038   23.28979 1.000 43.97125  ? 1029 LEU   A HA   1 
ATOM   1299 H  HB2  . LEU   A 1 86  ? 7.14092   0.05102   21.47863 1.000 42.11795  ? 1029 LEU   A HB2  1 
ATOM   1300 H  HB3  . LEU   A 1 86  ? 8.44613   -0.82510  21.71159 1.000 42.11795  ? 1029 LEU   A HB3  1 
ATOM   1301 H  HG   . LEU   A 1 86  ? 6.48688   -0.53570  23.70686 1.000 42.26055  ? 1029 LEU   A HG   1 
ATOM   1302 H  HD11 . LEU   A 1 86  ? 5.63857   -2.61125  23.14221 1.000 44.19488  ? 1029 LEU   A HD11 1 
ATOM   1303 H  HD12 . LEU   A 1 86  ? 5.45132   -1.59106  21.93902 1.000 44.19488  ? 1029 LEU   A HD12 1 
ATOM   1304 H  HD13 . LEU   A 1 86  ? 6.61513   -2.67121  21.89071 1.000 44.19488  ? 1029 LEU   A HD13 1 
ATOM   1305 H  HD21 . LEU   A 1 86  ? 7.56027   -2.50466  24.56878 1.000 45.24494  ? 1029 LEU   A HD21 1 
ATOM   1306 H  HD22 . LEU   A 1 86  ? 8.63710   -2.37214  23.40844 1.000 45.24494  ? 1029 LEU   A HD22 1 
ATOM   1307 H  HD23 . LEU   A 1 86  ? 8.54248   -1.25660  24.53544 1.000 45.24494  ? 1029 LEU   A HD23 1 
ATOM   1308 N  N    . PHE   A 1 87  ? 10.34094  1.15574   21.08841 1.000 37.16493  ? 1030 PHE   A N    1 
ATOM   1309 C  CA   . PHE   A 1 87  ? 11.15340  1.74520   20.03931 1.000 34.72044  ? 1030 PHE   A CA   1 
ATOM   1310 C  C    . PHE   A 1 87  ? 10.85078  1.10816   18.69968 1.000 34.91023  ? 1030 PHE   A C    1 
ATOM   1311 O  O    . PHE   A 1 87  ? 10.48883  -0.07590  18.60193 1.000 31.89957  ? 1030 PHE   A O    1 
ATOM   1312 C  CB   . PHE   A 1 87  ? 12.64757  1.60708   20.34347 1.000 31.64904  ? 1030 PHE   A CB   1 
ATOM   1313 C  CG   . PHE   A 1 87  ? 13.09264  2.40977   21.53056 1.000 36.59764  ? 1030 PHE   A CG   1 
ATOM   1314 C  CD1  . PHE   A 1 87  ? 13.30547  3.77150   21.42441 1.000 43.66442  ? 1030 PHE   A CD1  1 
ATOM   1315 C  CD2  . PHE   A 1 87  ? 13.29784  1.80968   22.74710 1.000 42.53636  ? 1030 PHE   A CD2  1 
ATOM   1316 C  CE1  . PHE   A 1 87  ? 13.72813  4.50479   22.49478 1.000 37.43754  ? 1030 PHE   A CE1  1 
ATOM   1317 C  CE2  . PHE   A 1 87  ? 13.71425  2.54666   23.83654 1.000 42.41693  ? 1030 PHE   A CE2  1 
ATOM   1318 C  CZ   . PHE   A 1 87  ? 13.93122  3.90043   23.70046 1.000 40.32179  ? 1030 PHE   A CZ   1 
ATOM   1319 H  H    . PHE   A 1 87  ? 10.66132  0.42186   21.40206 1.000 44.61319  ? 1030 PHE   A H    1 
ATOM   1320 H  HA   . PHE   A 1 87  ? 10.94175  2.69012   19.98234 1.000 41.67980  ? 1030 PHE   A HA   1 
ATOM   1321 H  HB2  . PHE   A 1 87  ? 12.84533  0.67478   20.52400 1.000 37.99412  ? 1030 PHE   A HB2  1 
ATOM   1322 H  HB3  . PHE   A 1 87  ? 13.15310  1.91033   19.57316 1.000 37.99412  ? 1030 PHE   A HB3  1 
ATOM   1323 H  HD1  . PHE   A 1 87  ? 13.15809  4.19506   20.60968 1.000 52.41258  ? 1030 PHE   A HD1  1 
ATOM   1324 H  HD2  . PHE   A 1 87  ? 13.15455  0.89534   22.83847 1.000 51.05891  ? 1030 PHE   A HD2  1 
ATOM   1325 H  HE1  . PHE   A 1 87  ? 13.87793  5.41795   22.40201 1.000 44.94032  ? 1030 PHE   A HE1  1 
ATOM   1326 H  HE2  . PHE   A 1 87  ? 13.84775  2.13196   24.65819 1.000 50.91560  ? 1030 PHE   A HE2  1 
ATOM   1327 H  HZ   . PHE   A 1 87  ? 14.21594  4.40175   24.43020 1.000 48.40142  ? 1030 PHE   A HZ   1 
ATOM   1328 N  N    . HIS   A 1 88  ? 10.98732  1.92142   17.66512 1.000 26.29190  ? 1031 HIS   A N    1 
ATOM   1329 C  CA   . HIS   A 1 88  ? 10.84232  1.48663   16.28761 1.000 35.23424  ? 1031 HIS   A CA   1 
ATOM   1330 C  C    . HIS   A 1 88  ? 11.89816  2.16737   15.44443 1.000 36.65501  ? 1031 HIS   A C    1 
ATOM   1331 O  O    . HIS   A 1 88  ? 11.96489  3.40549   15.40944 1.000 32.17252  ? 1031 HIS   A O    1 
ATOM   1332 C  CB   . HIS   A 1 88  ? 9.46917   1.81237   15.72954 1.000 31.03486  ? 1031 HIS   A CB   1 
ATOM   1333 C  CG   . HIS   A 1 88  ? 9.26032   1.26838   14.36189 1.000 36.40228  ? 1031 HIS   A CG   1 
ATOM   1334 N  ND1  . HIS   A 1 88  ? 8.97884   -0.06087  14.14081 1.000 36.10265  ? 1031 HIS   A ND1  1 
ATOM   1335 C  CD2  . HIS   A 1 88  ? 9.34800   1.84840   13.14350 1.000 37.37308  ? 1031 HIS   A CD2  1 
ATOM   1336 C  CE1  . HIS   A 1 88  ? 8.87215   -0.26739  12.83792 1.000 43.71743  ? 1031 HIS   A CE1  1 
ATOM   1337 N  NE2  . HIS   A 1 88  ? 9.07232   0.87767   12.21448 1.000 42.42160  ? 1031 HIS   A NE2  1 
ATOM   1338 H  H    . HIS   A 1 88  ? 11.17032  2.75854   17.73814 1.000 31.56555  ? 1031 HIS   A H    1 
ATOM   1339 H  HA   . HIS   A 1 88  ? 10.97348  0.52605   16.25629 1.000 42.29637  ? 1031 HIS   A HA   1 
ATOM   1340 H  HB2  . HIS   A 1 88  ? 8.79327   1.43043   16.31108 1.000 37.25711  ? 1031 HIS   A HB2  1 
ATOM   1341 H  HB3  . HIS   A 1 88  ? 9.36548   2.77594   15.68851 1.000 37.25711  ? 1031 HIS   A HB3  1 
ATOM   1342 H  HD1  . HIS   A 1 88  ? 8.88715   -0.66020  14.75072 1.000 43.33846  ? 1031 HIS   A HD1  1 
ATOM   1343 H  HD2  . HIS   A 1 88  ? 9.55600   2.73778   12.96846 1.000 44.86297  ? 1031 HIS   A HD2  1 
ATOM   1344 H  HE1  . HIS   A 1 88  ? 8.68717   -1.08266  12.43048 1.000 52.47619  ? 1031 HIS   A HE1  1 
ATOM   1345 N  N    . GLY   A 1 89  ? 12.71319  1.35934   14.78281 1.000 33.49191  ? 1032 GLY   A N    1 
ATOM   1346 C  CA   . GLY   A 1 89  ? 13.69847  1.84658   13.84410 1.000 33.04387  ? 1032 GLY   A CA   1 
ATOM   1347 C  C    . GLY   A 1 89  ? 13.34400  1.35427   12.46853 1.000 42.68051  ? 1032 GLY   A C    1 
ATOM   1348 O  O    . GLY   A 1 89  ? 13.00592  0.17220   12.28517 1.000 42.00860  ? 1032 GLY   A O    1 
ATOM   1349 H  H    . GLY   A 1 89  ? 12.71245  0.50324   14.86468 1.000 40.20557  ? 1032 GLY   A H    1 
ATOM   1350 H  HA2  . GLY   A 1 89  ? 13.71005  2.81651   13.84459 1.000 39.66792  ? 1032 GLY   A HA2  1 
ATOM   1351 H  HA3  . GLY   A 1 89  ? 14.57969  1.52012   14.08447 1.000 39.66792  ? 1032 GLY   A HA3  1 
ATOM   1352 N  N    . SER   A 1 90  ? 13.35163  2.25192   11.48384 1.000 31.03789  ? 1033 SER   A N    1 
ATOM   1353 C  CA   . SER   A 1 90  ? 12.96834  1.88428   10.13451 1.000 29.60679  ? 1033 SER   A CA   1 
ATOM   1354 C  C    . SER   A 1 90  ? 13.44232  2.94405   9.17180  1.000 45.45278  ? 1033 SER   A C    1 
ATOM   1355 O  O    . SER   A 1 90  ? 13.46681  4.13005   9.52183  1.000 45.15000  ? 1033 SER   A O    1 
ATOM   1356 C  CB   . SER   A 1 90  ? 11.45674  1.72347   9.99414  1.000 38.40851  ? 1033 SER   A CB   1 
ATOM   1357 O  OG   . SER   A 1 90  ? 11.12379  1.74232   8.62321  1.000 40.75043  ? 1033 SER   A OG   1 
ATOM   1358 H  H    . SER   A 1 90  ? 13.57539  3.07694   11.57802 1.000 37.26074  ? 1033 SER   A H    1 
ATOM   1359 H  HA   . SER   A 1 90  ? 13.40046  1.04315   9.91846  1.000 35.54342  ? 1033 SER   A HA   1 
ATOM   1360 H  HB2  . SER   A 1 90  ? 11.18342  0.87761   10.38238 1.000 46.10549  ? 1033 SER   A HB2  1 
ATOM   1361 H  HB3  . SER   A 1 90  ? 11.00958  2.45594   10.44630 1.000 46.10549  ? 1033 SER   A HB3  1 
ATOM   1362 H  HG   . SER   A 1 90  ? 10.29362  1.65657   8.52797  1.000 48.91580  ? 1033 SER   A HG   1 
ATOM   1363 N  N    . PRO   A 1 91  ? 13.78529  2.55872   7.94641  1.000 45.99013  ? 1034 PRO   A N    1 
ATOM   1364 C  CA   . PRO   A 1 91  ? 14.02665  3.56113   6.90954  1.000 40.53963  ? 1034 PRO   A CA   1 
ATOM   1365 C  C    . PRO   A 1 91  ? 12.79469  4.40469   6.58086  1.000 43.63446  ? 1034 PRO   A C    1 
ATOM   1366 O  O    . PRO   A 1 91  ? 12.94011  5.43629   5.92396  1.000 44.73607  ? 1034 PRO   A O    1 
ATOM   1367 C  CB   . PRO   A 1 91  ? 14.46080  2.72226   5.70732  1.000 37.77931  ? 1034 PRO   A CB   1 
ATOM   1368 C  CG   . PRO   A 1 91  ? 14.68148  1.33410   6.24147  1.000 46.64256  ? 1034 PRO   A CG   1 
ATOM   1369 C  CD   . PRO   A 1 91  ? 13.80903  1.19014   7.40144  1.000 46.51747  ? 1034 PRO   A CD   1 
ATOM   1370 H  HA   . PRO   A 1 91  ? 14.75563  4.14573   7.16979  1.000 48.66284  ? 1034 PRO   A HA   1 
ATOM   1371 H  HB2  . PRO   A 1 91  ? 13.76133  2.72613   5.03528  1.000 45.35045  ? 1034 PRO   A HB2  1 
ATOM   1372 H  HB3  . PRO   A 1 91  ? 15.28064  3.08297   5.33494  1.000 45.35045  ? 1034 PRO   A HB3  1 
ATOM   1373 H  HG2  . PRO   A 1 91  ? 14.45144  0.68401   5.55929  1.000 55.98635  ? 1034 PRO   A HG2  1 
ATOM   1374 H  HG3  . PRO   A 1 91  ? 15.61083  1.22993   6.49907  1.000 55.98635  ? 1034 PRO   A HG3  1 
ATOM   1375 H  HD2  . PRO   A 1 91  ? 12.92069  0.90416   7.13690  1.000 55.83624  ? 1034 PRO   A HD2  1 
ATOM   1376 H  HD3  . PRO   A 1 91  ? 14.18141  0.56519   8.04305  1.000 55.83624  ? 1034 PRO   A HD3  1 
ATOM   1377 N  N    . PHE   A 1 92  ? 11.59955  4.02194   7.01935  1.000 44.92790  ? 1035 PHE   A N    1 
ATOM   1378 C  CA   . PHE   A 1 92  ? 10.39494  4.76154   6.67231  1.000 40.01505  ? 1035 PHE   A CA   1 
ATOM   1379 C  C    . PHE   A 1 92  ? 9.94698   5.72260   7.75580  1.000 35.96602  ? 1035 PHE   A C    1 
ATOM   1380 O  O    . PHE   A 1 92  ? 8.79212   6.15926   7.72422  1.000 37.97446  ? 1035 PHE   A O    1 
ATOM   1381 C  CB   . PHE   A 1 92  ? 9.27384   3.77817   6.34103  1.000 52.34068  ? 1035 PHE   A CB   1 
ATOM   1382 C  CG   . PHE   A 1 92  ? 9.67739   2.77454   5.29999  1.000 57.96801  ? 1035 PHE   A CG   1 
ATOM   1383 C  CD1  . PHE   A 1 92  ? 10.66303  3.09002   4.38112  1.000 55.43851  ? 1035 PHE   A CD1  1 
ATOM   1384 C  CD2  . PHE   A 1 92  ? 9.10986   1.52461   5.25476  1.000 63.04497  ? 1035 PHE   A CD2  1 
ATOM   1385 C  CE1  . PHE   A 1 92  ? 11.06467  2.18807   3.44185  1.000 58.18251  ? 1035 PHE   A CE1  1 
ATOM   1386 C  CE2  . PHE   A 1 92  ? 9.50524   0.61391   4.30883  1.000 58.01141  ? 1035 PHE   A CE2  1 
ATOM   1387 C  CZ   . PHE   A 1 92  ? 10.48370  0.94205   3.40305  1.000 55.38366  ? 1035 PHE   A CZ   1 
ATOM   1388 H  H    . PHE   A 1 92  ? 11.46291  3.33597   7.51974  1.000 53.92876  ? 1035 PHE   A H    1 
ATOM   1389 H  HA   . PHE   A 1 92  ? 10.58365  5.29683   5.88570  1.000 48.03333  ? 1035 PHE   A HA   1 
ATOM   1390 H  HB2  . PHE   A 1 92  ? 9.02826   3.29533   7.14568  1.000 62.82409  ? 1035 PHE   A HB2  1 
ATOM   1391 H  HB3  . PHE   A 1 92  ? 8.50964   4.27128   6.00376  1.000 62.82409  ? 1035 PHE   A HB3  1 
ATOM   1392 H  HD1  . PHE   A 1 92  ? 11.05790  3.93168   4.40506  1.000 66.54148  ? 1035 PHE   A HD1  1 
ATOM   1393 H  HD2  . PHE   A 1 92  ? 8.45218   1.29405   5.87056  1.000 75.66924  ? 1035 PHE   A HD2  1 
ATOM   1394 H  HE1  . PHE   A 1 92  ? 11.72802  2.41387   2.83040  1.000 69.83429  ? 1035 PHE   A HE1  1 
ATOM   1395 H  HE2  . PHE   A 1 92  ? 9.10999   -0.22745  4.28073  1.000 69.62896  ? 1035 PHE   A HE2  1 
ATOM   1396 H  HZ   . PHE   A 1 92  ? 10.75325  0.32243   2.76405  1.000 66.47567  ? 1035 PHE   A HZ   1 
ATOM   1397 N  N    . VAL   A 1 93  ? 10.82882  6.07566   8.70966  1.000 39.76298  ? 1036 VAL   A N    1 
ATOM   1398 C  CA   . VAL   A 1 93  ? 10.39678  6.91182   9.82571  1.000 43.85915  ? 1036 VAL   A CA   1 
ATOM   1399 C  C    . VAL   A 1 93  ? 9.70600   8.16510   9.31520  1.000 43.70616  ? 1036 VAL   A C    1 
ATOM   1400 O  O    . VAL   A 1 93  ? 8.71711   8.60759   9.89415  1.000 50.25130  ? 1036 VAL   A O    1 
ATOM   1401 C  CB   . VAL   A 1 93  ? 11.56302  7.26952   10.76807 1.000 48.98646  ? 1036 VAL   A CB   1 
ATOM   1402 C  CG1  . VAL   A 1 93  ? 11.85382  6.13142   11.73677 1.000 59.77007  ? 1036 VAL   A CG1  1 
ATOM   1403 C  CG2  . VAL   A 1 93  ? 12.77574  7.58187   9.99083  1.000 55.65376  ? 1036 VAL   A CG2  1 
ATOM   1404 H  H    . VAL   A 1 93  ? 11.65768  5.84698   8.72671  1.000 47.73086  ? 1036 VAL   A H    1 
ATOM   1405 H  HA   . VAL   A 1 93  ? 9.76264   6.39016   10.34207 1.000 52.64625  ? 1036 VAL   A HA   1 
ATOM   1406 H  HB   . VAL   A 1 93  ? 11.30699  8.05086   11.28271 1.000 58.79903  ? 1036 VAL   A HB   1 
ATOM   1407 H  HG11 . VAL   A 1 93  ? 12.52554  6.42230   12.37323 1.000 71.73936  ? 1036 VAL   A HG11 1 
ATOM   1408 H  HG12 . VAL   A 1 93  ? 11.03616  5.89673   12.20287 1.000 71.73936  ? 1036 VAL   A HG12 1 
ATOM   1409 H  HG13 . VAL   A 1 93  ? 12.18071  5.36706   11.23698 1.000 71.73936  ? 1036 VAL   A HG13 1 
ATOM   1410 H  HG21 . VAL   A 1 93  ? 13.37790  8.10575   10.54205 1.000 66.79979  ? 1036 VAL   A HG21 1 
ATOM   1411 H  HG22 . VAL   A 1 93  ? 13.20483  6.75253   9.72820  1.000 66.79979  ? 1036 VAL   A HG22 1 
ATOM   1412 H  HG23 . VAL   A 1 93  ? 12.52400  8.08810   9.20263  1.000 66.79979  ? 1036 VAL   A HG23 1 
ATOM   1413 N  N    . ASN   A 1 94  ? 10.16898  8.73011   8.19668  1.000 44.68939  ? 1037 ASN   A N    1 
ATOM   1414 C  CA   . ASN   A 1 94  ? 9.53845   9.96018   7.71757  1.000 46.79469  ? 1037 ASN   A CA   1 
ATOM   1415 C  C    . ASN   A 1 94  ? 8.14215   9.70693   7.16764  1.000 50.07900  ? 1037 ASN   A C    1 
ATOM   1416 O  O    . ASN   A 1 94  ? 7.23964   10.53738  7.34160  1.000 55.66761  ? 1037 ASN   A O    1 
ATOM   1417 C  CB   . ASN   A 1 94  ? 10.41337  10.64447  6.67683  1.000 60.84230  ? 1037 ASN   A CB   1 
ATOM   1418 C  CG   . ASN   A 1 94  ? 11.32807  11.68225  7.30136  1.000 73.59221  ? 1037 ASN   A CG   1 
ATOM   1419 O  OD1  . ASN   A 1 94  ? 10.88931  12.78700  7.65608  1.000 76.69609  ? 1037 ASN   A OD1  1 
ATOM   1420 N  ND2  . ASN   A 1 94  ? 12.60116  11.32589  7.47161  1.000 87.87333  ? 1037 ASN   A ND2  1 
ATOM   1421 H  H    . ASN   A 1 94  ? 10.81883  8.43382   7.71762  1.000 53.64255  ? 1037 ASN   A H    1 
ATOM   1422 H  HA   . ASN   A 1 94  ? 9.45299   10.56931  8.46761  1.000 56.16890  ? 1037 ASN   A HA   1 
ATOM   1423 H  HB2  . ASN   A 1 94  ? 10.96496  9.97943   6.23597  1.000 73.02603  ? 1037 ASN   A HB2  1 
ATOM   1424 H  HB3  . ASN   A 1 94  ? 9.84768   11.09001  6.02691  1.000 73.02603  ? 1037 ASN   A HB3  1 
ATOM   1425 H  HD21 . ASN   A 1 94  ? 13.15934  11.87872  7.82150  1.000 105.46327 ? 1037 ASN   A HD21 1 
ATOM   1426 H  HD22 . ASN   A 1 94  ? 12.86437  10.54313  7.23158  1.000 105.46327 ? 1037 ASN   A HD22 1 
ATOM   1427 N  N    . ALA   A 1 95  ? 7.90646   8.57416   6.53432  1.000 48.88036  ? 1038 ALA   A N    1 
ATOM   1428 C  CA   . ALA   A 1 95  ? 6.52699   8.29732   6.16852  1.000 38.64852  ? 1038 ALA   A CA   1 
ATOM   1429 C  C    . ALA   A 1 95  ? 5.70019   8.12849   7.41859  1.000 46.16546  ? 1038 ALA   A C    1 
ATOM   1430 O  O    . ALA   A 1 95  ? 4.61619   8.70746   7.53431  1.000 50.39472  ? 1038 ALA   A O    1 
ATOM   1431 C  CB   . ALA   A 1 95  ? 6.40824   7.04817   5.30450  1.000 49.24851  ? 1038 ALA   A CB   1 
ATOM   1432 H  H    . ALA   A 1 95  ? 8.49021   7.98160   6.31590  1.000 58.67170  ? 1038 ALA   A H    1 
ATOM   1433 H  HA   . ALA   A 1 95  ? 6.19546   9.03847   5.63777  1.000 46.39351  ? 1038 ALA   A HA   1 
ATOM   1434 H  HB1  . ALA   A 1 95  ? 5.47891   6.92301   5.05634  1.000 59.11349  ? 1038 ALA   A HB1  1 
ATOM   1435 H  HB2  . ALA   A 1 95  ? 6.95072   7.16204   4.50849  1.000 59.11349  ? 1038 ALA   A HB2  1 
ATOM   1436 H  HB3  . ALA   A 1 95  ? 6.72124   6.28267   5.81139  1.000 59.11349  ? 1038 ALA   A HB3  1 
ATOM   1437 N  N    . ILE   A 1 96  ? 6.24189   7.37362   8.37671  1.000 39.31744  ? 1039 ILE   A N    1 
ATOM   1438 C  CA   . ILE   A 1 96  ? 5.48861   7.00276   9.56510  1.000 46.89172  ? 1039 ILE   A CA   1 
ATOM   1439 C  C    . ILE   A 1 96  ? 4.99995   8.23584   10.31395 1.000 45.32105  ? 1039 ILE   A C    1 
ATOM   1440 O  O    . ILE   A 1 96  ? 3.84405   8.29421   10.74330 1.000 36.30948  ? 1039 ILE   A O    1 
ATOM   1441 C  CB   . ILE   A 1 96  ? 6.34276   6.10731   10.46562 1.000 40.75121  ? 1039 ILE   A CB   1 
ATOM   1442 C  CG1  . ILE   A 1 96  ? 6.56337   4.75661   9.80005  1.000 41.14036  ? 1039 ILE   A CG1  1 
ATOM   1443 C  CG2  . ILE   A 1 96  ? 5.65384   5.91790   11.78144 1.000 41.38266  ? 1039 ILE   A CG2  1 
ATOM   1444 C  CD1  . ILE   A 1 96  ? 7.74401   3.99463   10.42111 1.000 43.36269  ? 1039 ILE   A CD1  1 
ATOM   1445 H  H    . ILE   A 1 96  ? 7.04442   7.06501   8.35933  1.000 47.19620  ? 1039 ILE   A H    1 
ATOM   1446 H  HA   . ILE   A 1 96  ? 4.70441   6.50586   9.28400  1.000 56.28534  ? 1039 ILE   A HA   1 
ATOM   1447 H  HB   . ILE   A 1 96  ? 7.20319   6.53190   10.60807 1.000 48.91673  ? 1039 ILE   A HB   1 
ATOM   1448 H  HG12 . ILE   A 1 96  ? 5.76480   4.21591   9.90414  1.000 49.38371  ? 1039 ILE   A HG12 1 
ATOM   1449 H  HG13 . ILE   A 1 96  ? 6.75161   4.89246   8.85824  1.000 49.38371  ? 1039 ILE   A HG13 1 
ATOM   1450 H  HG21 . ILE   A 1 96  ? 6.03446   5.14606   12.22897 1.000 49.67446  ? 1039 ILE   A HG21 1 
ATOM   1451 H  HG22 . ILE   A 1 96  ? 5.78397   6.71191   12.32322 1.000 49.67446  ? 1039 ILE   A HG22 1 
ATOM   1452 H  HG23 . ILE   A 1 96  ? 4.70718   5.77590   11.62471 1.000 49.67446  ? 1039 ILE   A HG23 1 
ATOM   1453 H  HD11 . ILE   A 1 96  ? 7.88195   3.17034   9.92876  1.000 52.05050  ? 1039 ILE   A HD11 1 
ATOM   1454 H  HD12 . ILE   A 1 96  ? 8.53914   4.54780   10.36943 1.000 52.05050  ? 1039 ILE   A HD12 1 
ATOM   1455 H  HD13 . ILE   A 1 96  ? 7.53902   3.79587   11.34814 1.000 52.05050  ? 1039 ILE   A HD13 1 
ATOM   1456 N  N    . ILE   A 1 97  ? 5.87351   9.23265   10.50929 1.000 34.77169  ? 1040 ILE   A N    1 
ATOM   1457 C  CA   . ILE   A 1 97  ? 5.46588   10.37899  11.31489 1.000 45.18128  ? 1040 ILE   A CA   1 
ATOM   1458 C  C    . ILE   A 1 97  ? 4.44723   11.25286  10.58622 1.000 44.16415  ? 1040 ILE   A C    1 
ATOM   1459 O  O    . ILE   A 1 97  ? 3.68063   11.97161  11.23714 1.000 40.03398  ? 1040 ILE   A O    1 
ATOM   1460 C  CB   . ILE   A 1 97  ? 6.66687   11.23979  11.75440 1.000 53.23986  ? 1040 ILE   A CB   1 
ATOM   1461 C  CG1  . ILE   A 1 97  ? 7.36956   11.87526  10.56344 1.000 52.18319  ? 1040 ILE   A CG1  1 
ATOM   1462 C  CG2  . ILE   A 1 97  ? 7.66826   10.41752  12.52060 1.000 50.20320  ? 1040 ILE   A CG2  1 
ATOM   1463 C  CD1  . ILE   A 1 97  ? 8.53927   12.71189  10.94648 1.000 54.07396  ? 1040 ILE   A CD1  1 
ATOM   1464 H  H    . ILE   A 1 97  ? 6.67429   9.26383   10.19723 1.000 41.74131  ? 1040 ILE   A H    1 
ATOM   1465 H  HA   . ILE   A 1 97  ? 5.05608   10.01732  12.11624 1.000 54.23281  ? 1040 ILE   A HA   1 
ATOM   1466 H  HB   . ILE   A 1 97  ? 6.30932   11.93975  12.32283 1.000 63.90310  ? 1040 ILE   A HB   1 
ATOM   1467 H  HG12 . ILE   A 1 97  ? 7.68616   11.17241  9.97465  1.000 62.63510  ? 1040 ILE   A HG12 1 
ATOM   1468 H  HG13 . ILE   A 1 97  ? 6.73869   12.44270  10.09342 1.000 62.63510  ? 1040 ILE   A HG13 1 
ATOM   1469 H  HG21 . ILE   A 1 97  ? 8.24005   11.01169  13.03139 1.000 60.25912  ? 1040 ILE   A HG21 1 
ATOM   1470 H  HG22 . ILE   A 1 97  ? 7.19394   9.81944   13.11911 1.000 60.25912  ? 1040 ILE   A HG22 1 
ATOM   1471 H  HG23 . ILE   A 1 97  ? 8.20104   9.90390   11.89350 1.000 60.25912  ? 1040 ILE   A HG23 1 
ATOM   1472 H  HD11 . ILE   A 1 97  ? 8.82262   13.22987  10.17686 1.000 64.90403  ? 1040 ILE   A HD11 1 
ATOM   1473 H  HD12 . ILE   A 1 97  ? 8.27978   13.30621  11.66783 1.000 64.90403  ? 1040 ILE   A HD12 1 
ATOM   1474 H  HD13 . ILE   A 1 97  ? 9.26005   12.13219  11.23859 1.000 64.90403  ? 1040 ILE   A HD13 1 
ATOM   1475 N  N    . HIS   A 1 98  ? 4.40918   11.21221  9.25192  1.000 49.68920  ? 1041 HIS   A N    1 
ATOM   1476 C  CA   . HIS   A 1 98  ? 3.44144   12.00198  8.49738  1.000 55.17383  ? 1041 HIS   A CA   1 
ATOM   1477 C  C    . HIS   A 1 98  ? 2.18388   11.23407  8.13390  1.000 49.34561  ? 1041 HIS   A C    1 
ATOM   1478 O  O    . HIS   A 1 98  ? 1.09026   11.80545  8.19430  1.000 46.81256  ? 1041 HIS   A O    1 
ATOM   1479 C  CB   . HIS   A 1 98  ? 4.08404   12.54887  7.22749  1.000 49.98940  ? 1041 HIS   A CB   1 
ATOM   1480 C  CG   . HIS   A 1 98  ? 5.08784   13.60666  7.50435  1.000 45.90101  ? 1041 HIS   A CG   1 
ATOM   1481 N  ND1  . HIS   A 1 98  ? 4.73103   14.87564  7.90660  1.000 47.30017  ? 1041 HIS   A ND1  1 
ATOM   1482 C  CD2  . HIS   A 1 98  ? 6.44183   13.57911  7.48717  1.000 42.92680  ? 1041 HIS   A CD2  1 
ATOM   1483 C  CE1  . HIS   A 1 98  ? 5.82308   15.58836  8.11761  1.000 45.68874  ? 1041 HIS   A CE1  1 
ATOM   1484 N  NE2  . HIS   A 1 98  ? 6.87183   14.82541  7.86680  1.000 44.96122  ? 1041 HIS   A NE2  1 
ATOM   1485 H  H    . HIS   A 1 98  ? 4.93369   10.73494  8.76539  1.000 59.64231  ? 1041 HIS   A H    1 
ATOM   1486 H  HA   . HIS   A 1 98  ? 3.17126   12.75540  9.04535  1.000 66.22388  ? 1041 HIS   A HA   1 
ATOM   1487 H  HB2  . HIS   A 1 98  ? 4.53100   11.82455  6.76220  1.000 60.00256  ? 1041 HIS   A HB2  1 
ATOM   1488 H  HB3  . HIS   A 1 98  ? 3.39362   12.92993  6.66269  1.000 60.00256  ? 1041 HIS   A HB3  1 
ATOM   1489 H  HD1  . HIS   A 1 98  ? 3.92491   15.15872  8.00473  1.000 56.77548  ? 1041 HIS   A HD1  1 
ATOM   1490 H  HD2  . HIS   A 1 98  ? 6.97794   12.85360  7.26109  1.000 51.52744  ? 1041 HIS   A HD2  1 
ATOM   1491 H  HE1  . HIS   A 1 98  ? 5.84908   16.47556  8.39526  1.000 54.84176  ? 1041 HIS   A HE1  1 
ATOM   1492 N  N    . LYS   A 1 99  ? 2.32219   9.95986   7.76118  1.000 46.37578  ? 1042 LYS   A N    1 
ATOM   1493 C  CA   . LYS   A 1 99  ? 1.20195   9.13220   7.35085  1.000 47.98139  ? 1042 LYS   A CA   1 
ATOM   1494 C  C    . LYS   A 1 99  ? 0.72693   8.17982   8.43425  1.000 50.49857  ? 1042 LYS   A C    1 
ATOM   1495 O  O    . LYS   A 1 99  ? -0.37808  7.65668   8.31969  1.000 46.89648  ? 1042 LYS   A O    1 
ATOM   1496 C  CB   . LYS   A 1 99  ? 1.56941   8.30698   6.10971  1.000 57.59296  ? 1042 LYS   A CB   1 
ATOM   1497 C  CG   . LYS   A 1 99  ? 2.22666   9.10264   4.99682  1.000 57.39763  ? 1042 LYS   A CG   1 
ATOM   1498 C  CD   . LYS   A 1 99  ? 1.34223   10.25545  4.55219  1.000 60.79118  ? 1042 LYS   A CD   1 
ATOM   1499 C  CE   . LYS   A 1 99  ? 2.07535   11.22400  3.60262  1.000 74.77177  ? 1042 LYS   A CE   1 
ATOM   1500 N  NZ   . LYS   A 1 99  ? 1.75916   12.67374  3.91007  1.000 86.20892  ? 1042 LYS   A NZ   1 
ATOM   1501 H  H    . LYS   A 1 99  ? 3.07626   9.54696   7.73900  1.000 55.66621  ? 1042 LYS   A H    1 
ATOM   1502 H  HA   . LYS   A 1 99  ? 0.46428   9.71714   7.11724  1.000 57.59294  ? 1042 LYS   A HA   1 
ATOM   1503 H  HB2  . LYS   A 1 99  ? 2.18793   7.60851   6.37518  1.000 69.12683  ? 1042 LYS   A HB2  1 
ATOM   1504 H  HB3  . LYS   A 1 99  ? 0.75932   7.91343   5.74947  1.000 69.12683  ? 1042 LYS   A HB3  1 
ATOM   1505 H  HG2  . LYS   A 1 99  ? 3.06814   9.46649   5.31372  1.000 68.89243  ? 1042 LYS   A HG2  1 
ATOM   1506 H  HG3  . LYS   A 1 99  ? 2.38179   8.52358   4.23424  1.000 68.89243  ? 1042 LYS   A HG3  1 
ATOM   1507 H  HD2  . LYS   A 1 99  ? 0.56979   9.90162   4.08417  1.000 72.96469  ? 1042 LYS   A HD2  1 
ATOM   1508 H  HD3  . LYS   A 1 99  ? 1.05674   10.75654  5.33213  1.000 72.96469  ? 1042 LYS   A HD3  1 
ATOM   1509 H  HE2  . LYS   A 1 99  ? 3.03259   11.09718  3.69485  1.000 89.74140  ? 1042 LYS   A HE2  1 
ATOM   1510 H  HE3  . LYS   A 1 99  ? 1.80306   11.04223  2.68953  1.000 89.74140  ? 1042 LYS   A HE3  1 
ATOM   1511 H  HZ1  . LYS   A 1 99  ? 2.18316   13.20603  3.33648  1.000 103.46598 ? 1042 LYS   A HZ1  1 
ATOM   1512 H  HZ2  . LYS   A 1 99  ? 0.88313   12.81529  3.84202  1.000 103.46598 ? 1042 LYS   A HZ2  1 
ATOM   1513 H  HZ3  . LYS   A 1 99  ? 2.02066   12.87358  4.73698  1.000 103.46598 ? 1042 LYS   A HZ3  1 
ATOM   1514 N  N    . GLY   A 1 100 ? 1.50734   7.94905   9.48311  1.000 52.65992  ? 1043 GLY   A N    1 
ATOM   1515 C  CA   . GLY   A 1 100 ? 1.15344   6.97676   10.48972 1.000 48.76958  ? 1043 GLY   A CA   1 
ATOM   1516 C  C    . GLY   A 1 100 ? 1.58127   5.58091   10.06604 1.000 49.46378  ? 1043 GLY   A C    1 
ATOM   1517 O  O    . GLY   A 1 100 ? 2.06401   5.35036   8.96230  1.000 52.58782  ? 1043 GLY   A O    1 
ATOM   1518 H  H    . GLY   A 1 100 ? 2.25363   8.35041   9.62996  1.000 63.20718  ? 1043 GLY   A H    1 
ATOM   1519 H  HA2  . GLY   A 1 100 ? 1.59193   7.19752   11.32632 1.000 58.53878  ? 1043 GLY   A HA2  1 
ATOM   1520 H  HA3  . GLY   A 1 100 ? 0.19303   6.98139   10.62574 1.000 58.53878  ? 1043 GLY   A HA3  1 
ATOM   1521 N  N    . PHE   A 1 101 ? 1.40216   4.63258   10.97263 1.000 44.34649  ? 1044 PHE   A N    1 
ATOM   1522 C  CA   . PHE   A 1 101 ? 1.80081   3.25766   10.69906 1.000 51.57069  ? 1044 PHE   A CA   1 
ATOM   1523 C  C    . PHE   A 1 101 ? 0.73623   2.57031   9.84567  1.000 52.75844  ? 1044 PHE   A C    1 
ATOM   1524 O  O    . PHE   A 1 101 ? -0.46217  2.75214   10.06067 1.000 46.94464  ? 1044 PHE   A O    1 
ATOM   1525 C  CB   . PHE   A 1 101 ? 1.99064   2.46964   12.00321 1.000 46.77200  ? 1044 PHE   A CB   1 
ATOM   1526 C  CG   . PHE   A 1 101 ? 3.28728   2.74851   12.76210 1.000 39.60642  ? 1044 PHE   A CG   1 
ATOM   1527 C  CD1  . PHE   A 1 101 ? 4.45490   2.12991   12.40927 1.000 39.05425  ? 1044 PHE   A CD1  1 
ATOM   1528 C  CD2  . PHE   A 1 101 ? 3.29664   3.53778   13.89024 1.000 39.41313  ? 1044 PHE   A CD2  1 
ATOM   1529 C  CE1  . PHE   A 1 101 ? 5.61823   2.35254   13.12529 1.000 40.19545  ? 1044 PHE   A CE1  1 
ATOM   1530 C  CE2  . PHE   A 1 101 ? 4.47645   3.75472   14.60811 1.000 38.18127  ? 1044 PHE   A CE2  1 
ATOM   1531 C  CZ   . PHE   A 1 101 ? 5.61142   3.15218   14.22141 1.000 32.40386  ? 1044 PHE   A CZ   1 
ATOM   1532 H  H    . PHE   A 1 101 ? 1.05443   4.75657   11.74936 1.000 53.23106  ? 1044 PHE   A H    1 
ATOM   1533 H  HA   . PHE   A 1 101 ? 2.64574   3.25923   10.22263 1.000 61.90010  ? 1044 PHE   A HA   1 
ATOM   1534 H  HB2  . PHE   A 1 101 ? 1.25625   2.68548   12.59902 1.000 56.14168  ? 1044 PHE   A HB2  1 
ATOM   1535 H  HB3  . PHE   A 1 101 ? 1.97887   1.52310   11.79148 1.000 56.14168  ? 1044 PHE   A HB3  1 
ATOM   1536 H  HD1  . PHE   A 1 101 ? 4.46733   1.55308   11.67988 1.000 46.88038  ? 1044 PHE   A HD1  1 
ATOM   1537 H  HD2  . PHE   A 1 101 ? 2.50580   3.93272   14.17917 1.000 47.31103  ? 1044 PHE   A HD2  1 
ATOM   1538 H  HE1  . PHE   A 1 101 ? 6.41137   1.95060   12.85276 1.000 48.24981  ? 1044 PHE   A HE1  1 
ATOM   1539 H  HE2  . PHE   A 1 101 ? 4.47474   4.31446   15.35080 1.000 45.83281  ? 1044 PHE   A HE2  1 
ATOM   1540 H  HZ   . PHE   A 1 101 ? 6.39464   3.28290   14.70554 1.000 38.89991  ? 1044 PHE   A HZ   1 
ATOM   1541 N  N    . ASP   A 1 102 ? 1.17541   1.76765   8.88340  1.000 57.32143  ? 1045 ASP   A N    1 
ATOM   1542 C  CA   . ASP   A 1 102 ? 0.26874   0.92137   8.10766  1.000 62.85124  ? 1045 ASP   A CA   1 
ATOM   1543 C  C    . ASP   A 1 102 ? 1.07765   -0.26129  7.58749  1.000 62.39681  ? 1045 ASP   A C    1 
ATOM   1544 O  O    . ASP   A 1 102 ? 2.22716   -0.46177  7.99163  1.000 57.47163  ? 1045 ASP   A O    1 
ATOM   1545 C  CB   . ASP   A 1 102 ? -0.42599  1.74847   7.01093  1.000 67.94214  ? 1045 ASP   A CB   1 
ATOM   1546 C  CG   . ASP   A 1 102 ? 0.49867   2.14037   5.84411  1.000 72.02561  ? 1045 ASP   A CG   1 
ATOM   1547 O  OD1  . ASP   A 1 102 ? 1.51584   1.48128   5.57035  1.000 79.07801  ? 1045 ASP   A OD1  1 
ATOM   1548 O  OD2  . ASP   A 1 102 ? 0.19032   3.13428   5.16664  1.000 79.48529  ? 1045 ASP   A OD2  1 
ATOM   1549 H  H    . ASP   A 1 102 ? 2.00161   1.69277   8.65671  1.000 68.80099  ? 1045 ASP   A H    1 
ATOM   1550 H  HA   . ASP   A 1 102 ? -0.43036  0.56547   8.67818  1.000 75.43676  ? 1045 ASP   A HA   1 
ATOM   1551 H  HB2  . ASP   A 1 102 ? -1.15820  1.22805   6.64499  1.000 81.54585  ? 1045 ASP   A HB2  1 
ATOM   1552 H  HB3  . ASP   A 1 102 ? -0.76549  2.56681   7.40585  1.000 81.54585  ? 1045 ASP   A HB3  1 
ATOM   1553 N  N    . GLU   A 1 103 ? 0.49502   -1.03375  6.65739  1.000 71.91323  ? 1046 GLU   A N    1 
ATOM   1554 C  CA   . GLU   A 1 103 ? 1.11436   -2.29221  6.23986  1.000 74.64171  ? 1046 GLU   A CA   1 
ATOM   1555 C  C    . GLU   A 1 103 ? 2.38141   -2.12411  5.40148  1.000 65.71887  ? 1046 GLU   A C    1 
ATOM   1556 O  O    . GLU   A 1 103 ? 3.05274   -3.12109  5.13954  1.000 59.48856  ? 1046 GLU   A O    1 
ATOM   1557 C  CB   . GLU   A 1 103 ? 0.12600   -3.16266  5.45445  1.000 75.87773  ? 1046 GLU   A CB   1 
ATOM   1558 C  CG   . GLU   A 1 103 ? -0.16614  -2.70514  4.05307  1.000 81.97843  ? 1046 GLU   A CG   1 
ATOM   1559 C  CD   . GLU   A 1 103 ? -1.05405  -1.49784  4.05017  1.000 90.67731  ? 1046 GLU   A CD   1 
ATOM   1560 O  OE1  . GLU   A 1 103 ? -1.52126  -1.13675  5.15811  1.000 81.89629  ? 1046 GLU   A OE1  1 
ATOM   1561 O  OE2  . GLU   A 1 103 ? -1.27893  -0.91605  2.96067  1.000 92.15129  ? 1046 GLU   A OE2  1 
ATOM   1562 H  H    . GLU   A 1 103 ? -0.24652  -0.85098  6.26202  1.000 86.31115  ? 1046 GLU   A H    1 
ATOM   1563 H  HA   . GLU   A 1 103 ? 1.35573   -2.75779  7.05587  1.000 89.58533  ? 1046 GLU   A HA   1 
ATOM   1564 H  HB2  . GLU   A 1 103 ? 0.48978   -4.05992  5.39537  1.000 91.06855  ? 1046 GLU   A HB2  1 
ATOM   1565 H  HB3  . GLU   A 1 103 ? -0.71645  -3.17721  5.93502  1.000 91.06855  ? 1046 GLU   A HB3  1 
ATOM   1566 H  HG2  . GLU   A 1 103 ? 0.66531   -2.47500  3.60964  1.000 98.38940  ? 1046 GLU   A HG2  1 
ATOM   1567 H  HG3  . GLU   A 1 103 ? -0.61444  -3.41628  3.56913  1.000 98.38940  ? 1046 GLU   A HG3  1 
ATOM   1568 N  N    . ARG   A 1 104 ? 2.72511   -0.91907  4.95661  1.000 69.92978  ? 1047 ARG   A N    1 
ATOM   1569 C  CA   . ARG   A 1 104 ? 4.00642   -0.74336  4.27794  1.000 68.02663  ? 1047 ARG   A CA   1 
ATOM   1570 C  C    . ARG   A 1 104 ? 5.17944   -0.75753  5.24276  1.000 61.51396  ? 1047 ARG   A C    1 
ATOM   1571 O  O    . ARG   A 1 104 ? 6.33548   -0.88644  4.81511  1.000 57.73358  ? 1047 ARG   A O    1 
ATOM   1572 C  CB   . ARG   A 1 104 ? 4.00567   0.56197   3.50383  1.000 77.21208  ? 1047 ARG   A CB   1 
ATOM   1573 C  CG   . ARG   A 1 104 ? 3.35269   0.45980   2.15403  1.000 80.20991  ? 1047 ARG   A CG   1 
ATOM   1574 C  CD   . ARG   A 1 104 ? 3.37276   1.81487   1.43492  1.000 109.02232 ? 1047 ARG   A CD   1 
ATOM   1575 N  NE   . ARG   A 1 104 ? 3.02948   2.93750   2.31025  1.000 102.12538 ? 1047 ARG   A NE   1 
ATOM   1576 C  CZ   . ARG   A 1 104 ? 1.83450   3.51377   2.39003  1.000 103.90512 ? 1047 ARG   A CZ   1 
ATOM   1577 N  NH1  . ARG   A 1 104 ? 0.81761   3.11711   1.63945  1.000 90.41267  ? 1047 ARG   A NH1  1 
ATOM   1578 N  NH2  . ARG   A 1 104 ? 1.65595   4.51579   3.24559  1.000 84.92140  ? 1047 ARG   A NH2  1 
ATOM   1579 H  H    . ARG   A 1 104 ? 2.24853   -0.20725  5.03263  1.000 83.93102  ? 1047 ARG   A H    1 
ATOM   1580 H  HA   . ARG   A 1 104 ? 4.12666   -1.46874  3.64528  1.000 81.64723  ? 1047 ARG   A HA   1 
ATOM   1581 H  HB2  . ARG   A 1 104 ? 3.52388   1.22937   4.01701  1.000 92.66978  ? 1047 ARG   A HB2  1 
ATOM   1582 H  HB3  . ARG   A 1 104 ? 4.92334   0.84589   3.36904  1.000 92.66978  ? 1047 ARG   A HB3  1 
ATOM   1583 H  HG2  . ARG   A 1 104 ? 3.83230   -0.18441  1.61009  1.000 96.26717  ? 1047 ARG   A HG2  1 
ATOM   1584 H  HG3  . ARG   A 1 104 ? 2.42956   0.18177   2.26096  1.000 96.26717  ? 1047 ARG   A HG3  1 
ATOM   1585 H  HD2  . ARG   A 1 104 ? 4.26352   1.97191   1.08453  1.000 130.84206 ? 1047 ARG   A HD2  1 
ATOM   1586 H  HD3  . ARG   A 1 104 ? 2.72944   1.79545   0.70920  1.000 130.84206 ? 1047 ARG   A HD3  1 
ATOM   1587 H  HE   . ARG   A 1 104 ? 3.65248   3.24966   2.81425  1.000 122.56573 ? 1047 ARG   A HE   1 
ATOM   1588 H  HH11 . ARG   A 1 104 ? 0.92116   2.47049   1.08199  1.000 108.51048 ? 1047 ARG   A HH11 1 
ATOM   1589 H  HH12 . ARG   A 1 104 ? 0.05388   3.50621   1.70962  1.000 108.51048 ? 1047 ARG   A HH12 1 
ATOM   1590 H  HH21 . ARG   A 1 104 ? 2.30885   4.78253   3.73770  1.000 101.92096 ? 1047 ARG   A HH21 1 
ATOM   1591 H  HH22 . ARG   A 1 104 ? 0.88757   4.89715   3.30685  1.000 101.92096 ? 1047 ARG   A HH22 1 
ATOM   1592 N  N    . HIS   A 1 105 ? 4.90433   -0.62360  6.52830  1.000 68.79508  ? 1048 HIS   A N    1 
ATOM   1593 C  CA   . HIS   A 1 105 ? 5.91667   -0.63748  7.56969  1.000 69.68668  ? 1048 HIS   A CA   1 
ATOM   1594 C  C    . HIS   A 1 105 ? 6.00668   -1.98893  8.25492  1.000 59.71089  ? 1048 HIS   A C    1 
ATOM   1595 O  O    . HIS   A 1 105 ? 6.89883   -2.19311  9.09344  1.000 54.73493  ? 1048 HIS   A O    1 
ATOM   1596 C  CB   . HIS   A 1 105 ? 5.59698   0.48739   8.54600  1.000 54.78100  ? 1048 HIS   A CB   1 
ATOM   1597 C  CG   . HIS   A 1 105 ? 5.23077   1.75221   7.84197  1.000 61.52492  ? 1048 HIS   A CG   1 
ATOM   1598 N  ND1  . HIS   A 1 105 ? 4.07253   2.44825   8.10111  1.000 53.32656  ? 1048 HIS   A ND1  1 
ATOM   1599 C  CD2  . HIS   A 1 105 ? 5.84288   2.40602   6.82658  1.000 52.09883  ? 1048 HIS   A CD2  1 
ATOM   1600 C  CE1  . HIS   A 1 105 ? 4.00069   3.49276   7.29701  1.000 68.60248  ? 1048 HIS   A CE1  1 
ATOM   1601 N  NE2  . HIS   A 1 105 ? 5.06545   3.49121   6.51630  1.000 60.21128  ? 1048 HIS   A NE2  1 
ATOM   1602 H  H    . HIS   A 1 105 ? 4.10772   -0.51922  6.83509  1.000 82.56937  ? 1048 HIS   A H    1 
ATOM   1603 H  HA   . HIS   A 1 105 ? 6.80146   -0.46435  7.21182  1.000 83.63929  ? 1048 HIS   A HA   1 
ATOM   1604 H  HB2  . HIS   A 1 105 ? 4.84842   0.22256   9.10316  1.000 65.75248  ? 1048 HIS   A HB2  1 
ATOM   1605 H  HB3  . HIS   A 1 105 ? 6.37572   0.66158   9.09746  1.000 65.75248  ? 1048 HIS   A HB3  1 
ATOM   1606 H  HD2  . HIS   A 1 105 ? 6.64163   2.16395   6.41633  1.000 62.53387  ? 1048 HIS   A HD2  1 
ATOM   1607 H  HE1  . HIS   A 1 105 ? 3.31652   4.12253   7.28286  1.000 82.33825  ? 1048 HIS   A HE1  1 
ATOM   1608 H  HE2  . HIS   A 1 105 ? 5.24243   4.07620   5.91127  1.000 72.26881  ? 1048 HIS   A HE2  1 
ATOM   1609 N  N    . ALA   A 1 106 ? 5.13208   -2.92247  7.88595  1.000 57.35786  ? 1049 ALA   A N    1 
ATOM   1610 C  CA   . ALA   A 1 106 ? 5.22777   -4.29531  8.36006  1.000 64.83221  ? 1049 ALA   A CA   1 
ATOM   1611 C  C    . ALA   A 1 106 ? 6.36647   -5.03990  7.66256  1.000 63.90906  ? 1049 ALA   A C    1 
ATOM   1612 O  O    . ALA   A 1 106 ? 6.75355   -4.72712  6.53523  1.000 62.31069  ? 1049 ALA   A O    1 
ATOM   1613 C  CB   . ALA   A 1 106 ? 3.90252   -5.02641  8.12443  1.000 61.74180  ? 1049 ALA   A CB   1 
ATOM   1614 H  H    . ALA   A 1 106 ? 4.46859   -2.78319  7.35681  1.000 68.84471  ? 1049 ALA   A H    1 
ATOM   1615 H  HA   . ALA   A 1 106 ? 5.41367   -4.29428  9.31207  1.000 77.81393  ? 1049 ALA   A HA   1 
ATOM   1616 H  HB1  . ALA   A 1 106 ? 3.97581   -5.93115  8.46644  1.000 74.10543  ? 1049 ALA   A HB1  1 
ATOM   1617 H  HB2  . ALA   A 1 106 ? 3.19414   -4.55364  8.58874  1.000 74.10543  ? 1049 ALA   A HB2  1 
ATOM   1618 H  HB3  . ALA   A 1 106 ? 3.71793   -5.04662  7.17237  1.000 74.10543  ? 1049 ALA   A HB3  1 
ATOM   1619 N  N    . TYR   A 1 107 ? 6.91158   -6.03376  8.35515  1.000 59.02334  ? 1050 TYR   A N    1 
ATOM   1620 C  CA   . TYR   A 1 107 ? 7.95407   -6.89552  7.80292  1.000 64.23991  ? 1050 TYR   A CA   1 
ATOM   1621 C  C    . TYR   A 1 107 ? 7.29593   -8.21641  7.42607  1.000 66.04205  ? 1050 TYR   A C    1 
ATOM   1622 O  O    . TYR   A 1 107 ? 6.99191   -9.03629  8.29262  1.000 66.99728  ? 1050 TYR   A O    1 
ATOM   1623 C  CB   . TYR   A 1 107 ? 9.07949   -7.11278  8.80147  1.000 51.11203  ? 1050 TYR   A CB   1 
ATOM   1624 C  CG   . TYR   A 1 107 ? 10.23427  -7.93446  8.27166  1.000 58.31788  ? 1050 TYR   A CG   1 
ATOM   1625 C  CD1  . TYR   A 1 107 ? 10.44338  -8.08633  6.90778  1.000 62.72524  ? 1050 TYR   A CD1  1 
ATOM   1626 C  CD2  . TYR   A 1 107 ? 11.11207  -8.55561  9.13416  1.000 58.51657  ? 1050 TYR   A CD2  1 
ATOM   1627 C  CE1  . TYR   A 1 107 ? 11.48989  -8.82124  6.42414  1.000 61.69427  ? 1050 TYR   A CE1  1 
ATOM   1628 C  CE2  . TYR   A 1 107 ? 12.17044  -9.29854  8.65578  1.000 56.63590  ? 1050 TYR   A CE2  1 
ATOM   1629 C  CZ   . TYR   A 1 107 ? 12.34325  -9.42908  7.29993  1.000 63.15666  ? 1050 TYR   A CZ   1 
ATOM   1630 O  OH   . TYR   A 1 107 ? 13.38029  -10.17184 6.81056  1.000 64.84409  ? 1050 TYR   A OH   1 
ATOM   1631 H  H    . TYR   A 1 107 ? 6.69078   -6.23315  9.16205  1.000 70.84329  ? 1050 TYR   A H    1 
ATOM   1632 H  HA   . TYR   A 1 107 ? 8.32841   -6.47956  7.01061  1.000 77.10317  ? 1050 TYR   A HA   1 
ATOM   1633 H  HB2  . TYR   A 1 107 ? 9.43109   -6.24786  9.06452  1.000 61.34972  ? 1050 TYR   A HB2  1 
ATOM   1634 H  HB3  . TYR   A 1 107 ? 8.72145   -7.57474  9.57562  1.000 61.34972  ? 1050 TYR   A HB3  1 
ATOM   1635 H  HD1  . TYR   A 1 107 ? 9.85879   -7.67924  6.30992  1.000 75.28556  ? 1050 TYR   A HD1  1 
ATOM   1636 H  HD2  . TYR   A 1 107 ? 10.98857  -8.47232  10.05215 1.000 70.23516  ? 1050 TYR   A HD2  1 
ATOM   1637 H  HE1  . TYR   A 1 107 ? 11.61938  -8.90640  5.50714  1.000 74.04840  ? 1050 TYR   A HE1  1 
ATOM   1638 H  HE2  . TYR   A 1 107 ? 12.76167  -9.70738  9.24587  1.000 67.97835  ? 1050 TYR   A HE2  1 
ATOM   1639 H  HH   . TYR   A 1 107 ? 13.78134  -10.55571 7.44096  1.000 77.82819  ? 1050 TYR   A HH   1 
ATOM   1640 N  N    . ILE   A 1 108 ? 7.08396   -8.42715  6.12255  1.000 75.45176  ? 1051 ILE   A N    1 
ATOM   1641 C  CA   . ILE   A 1 108 ? 6.35218   -9.61312  5.69412  1.000 76.48571  ? 1051 ILE   A CA   1 
ATOM   1642 C  C    . ILE   A 1 108 ? 7.09478   -10.86969 6.11607  1.000 64.06065  ? 1051 ILE   A C    1 
ATOM   1643 O  O    . ILE   A 1 108 ? 6.47330   -11.89763 6.40762  1.000 64.46633  ? 1051 ILE   A O    1 
ATOM   1644 C  CB   . ILE   A 1 108 ? 6.10250   -9.59738  4.16962  1.000 69.36466  ? 1051 ILE   A CB   1 
ATOM   1645 C  CG1  . ILE   A 1 108 ? 5.45921   -8.27035  3.72333  1.000 72.40158  ? 1051 ILE   A CG1  1 
ATOM   1646 C  CG2  . ILE   A 1 108 ? 5.22351   -10.79313 3.77114  1.000 61.06050  ? 1051 ILE   A CG2  1 
ATOM   1647 C  CD1  . ILE   A 1 108 ? 4.14125   -7.85133  4.46955  1.000 71.45509  ? 1051 ILE   A CD1  1 
ATOM   1648 H  H    . ILE   A 1 108 ? 7.34747   -7.91117  5.48699  1.000 90.55739  ? 1051 ILE   A H    1 
ATOM   1649 H  HA   . ILE   A 1 108 ? 5.48464   -9.60267  6.12791  1.000 91.79813  ? 1051 ILE   A HA   1 
ATOM   1650 H  HB   . ILE   A 1 108 ? 6.95886   -9.67177  3.72015  1.000 83.25287  ? 1051 ILE   A HB   1 
ATOM   1651 H  HG12 . ILE   A 1 108 ? 6.10447   -7.55971  3.86305  1.000 86.89717  ? 1051 ILE   A HG12 1 
ATOM   1652 H  HG13 . ILE   A 1 108 ? 5.24295   -8.34145  2.78042  1.000 86.89717  ? 1051 ILE   A HG13 1 
ATOM   1653 H  HG21 . ILE   A 1 108 ? 5.02195   -10.73519 2.82409  1.000 73.28788  ? 1051 ILE   A HG21 1 
ATOM   1654 H  HG22 . ILE   A 1 108 ? 5.70456   -11.61461 3.95729  1.000 73.28788  ? 1051 ILE   A HG22 1 
ATOM   1655 H  HG23 . ILE   A 1 108 ? 4.40208   -10.76682 4.28637  1.000 73.28788  ? 1051 ILE   A HG23 1 
ATOM   1656 H  HD11 . ILE   A 1 108 ? 3.80365   -7.03079  4.07757  1.000 85.76138  ? 1051 ILE   A HD11 1 
ATOM   1657 H  HD12 . ILE   A 1 108 ? 3.48480   -8.55882  4.37246  1.000 85.76138  ? 1051 ILE   A HD12 1 
ATOM   1658 H  HD13 . ILE   A 1 108 ? 4.34072   -7.71174  5.40850  1.000 85.76138  ? 1051 ILE   A HD13 1 
ATOM   1659 N  N    . GLY   A 1 109 ? 8.41950   -10.80042 6.19124  1.000 59.24569  ? 1052 GLY   A N    1 
ATOM   1660 C  CA   . GLY   A 1 109 ? 9.22741   -11.97727 6.43995  1.000 63.33897  ? 1052 GLY   A CA   1 
ATOM   1661 C  C    . GLY   A 1 109 ? 9.66087   -12.12734 7.87603  1.000 61.28864  ? 1052 GLY   A C    1 
ATOM   1662 O  O    . GLY   A 1 109 ? 10.60232  -12.86917 8.16522  1.000 59.61307  ? 1052 GLY   A O    1 
ATOM   1663 H  H    . GLY   A 1 109 ? 8.87395   -10.07596 6.10044  1.000 71.11010  ? 1052 GLY   A H    1 
ATOM   1664 H  HA2  . GLY   A 1 109 ? 8.71810   -12.76619 6.19682  1.000 76.02204  ? 1052 GLY   A HA2  1 
ATOM   1665 H  HA3  . GLY   A 1 109 ? 10.02483  -11.93410 5.88935  1.000 76.02204  ? 1052 GLY   A HA3  1 
ATOM   1666 N  N    . GLY   A 1 110 ? 8.96764   -11.45145 8.78485  1.000 56.59657  ? 1053 GLY   A N    1 
ATOM   1667 C  CA   . GLY   A 1 110 ? 9.36398   -11.48842 10.17575 1.000 59.58382  ? 1053 GLY   A CA   1 
ATOM   1668 C  C    . GLY   A 1 110 ? 9.11449   -12.83374 10.83373 1.000 58.65492  ? 1053 GLY   A C    1 
ATOM   1669 O  O    . GLY   A 1 110 ? 8.19324   -13.57338 10.48396 1.000 59.62384  ? 1053 GLY   A O    1 
ATOM   1670 H  H    . GLY   A 1 110 ? 8.27348   -10.97124 8.62011  1.000 67.93116  ? 1053 GLY   A H    1 
ATOM   1671 H  HA2  . GLY   A 1 110 ? 10.31140  -11.29106 10.24170 1.000 71.51586  ? 1053 GLY   A HA2  1 
ATOM   1672 H  HA3  . GLY   A 1 110 ? 8.86635   -10.81550 10.66610 1.000 71.51586  ? 1053 GLY   A HA3  1 
ATOM   1673 N  N    . MET   A 1 111 ? 9.96465   -13.13695 11.82016 1.000 56.34319  ? 1054 MET   A N    1 
ATOM   1674 C  CA   . MET   A 1 111 ? 9.78406   -14.26103 12.72697 1.000 66.83282  ? 1054 MET   A CA   1 
ATOM   1675 C  C    . MET   A 1 111 ? 8.33744   -14.48170 13.13816 1.000 67.82862  ? 1054 MET   A C    1 
ATOM   1676 O  O    . MET   A 1 111 ? 7.78169   -15.56583 12.94401 1.000 66.44432  ? 1054 MET   A O    1 
ATOM   1677 C  CB   . MET   A 1 111 ? 10.60126  -14.03637 14.00222 1.000 61.28556  ? 1054 MET   A CB   1 
ATOM   1678 C  CG   . MET   A 1 111 ? 12.06798  -14.26749 13.88012 1.000 69.95372  ? 1054 MET   A CG   1 
ATOM   1679 S  SD   . MET   A 1 111 ? 12.81955  -14.21461 15.49720 1.000 67.36632  ? 1054 MET   A SD   1 
ATOM   1680 C  CE   . MET   A 1 111 ? 12.07731  -12.73683 16.19991 1.000 68.48573  ? 1054 MET   A CE   1 
ATOM   1681 H  H    . MET   A 1 111 ? 10.67857  -12.68748 11.98718 1.000 67.62711  ? 1054 MET   A H    1 
ATOM   1682 H  HA   . MET   A 1 111 ? 10.10473  -15.04249 12.25011 1.000 80.21466  ? 1054 MET   A HA   1 
ATOM   1683 H  HB2  . MET   A 1 111 ? 10.47755  -13.11664 14.28452 1.000 73.55795  ? 1054 MET   A HB2  1 
ATOM   1684 H  HB3  . MET   A 1 111 ? 10.27081  -14.64043 14.68546 1.000 73.55795  ? 1054 MET   A HB3  1 
ATOM   1685 H  HG2  . MET   A 1 111 ? 12.23110  -15.13930 13.48739 1.000 83.95974  ? 1054 MET   A HG2  1 
ATOM   1686 H  HG3  . MET   A 1 111 ? 12.46425  -13.57546 13.32789 1.000 83.95974  ? 1054 MET   A HG3  1 
ATOM   1687 H  HE1  . MET   A 1 111 ? 12.40863  -12.61613 17.10355 1.000 82.19815  ? 1054 MET   A HE1  1 
ATOM   1688 H  HE2  . MET   A 1 111 ? 12.31871  -11.97210 15.65418 1.000 82.19815  ? 1054 MET   A HE2  1 
ATOM   1689 H  HE3  . MET   A 1 111 ? 11.11323  -12.84307 16.21252 1.000 82.19815  ? 1054 MET   A HE3  1 
ATOM   1690 N  N    . PHE   A 1 112 ? 7.73524   -13.47847 13.78021 1.000 61.89730  ? 1055 PHE   A N    1 
ATOM   1691 C  CA   . PHE   A 1 112 ? 6.39164   -13.61433 14.32417 1.000 60.67220  ? 1055 PHE   A CA   1 
ATOM   1692 C  C    . PHE   A 1 112 ? 5.30860   -13.16902 13.34486 1.000 56.15043  ? 1055 PHE   A C    1 
ATOM   1693 O  O    . PHE   A 1 112 ? 4.23020   -12.75058 13.77624 1.000 67.17975  ? 1055 PHE   A O    1 
ATOM   1694 C  CB   . PHE   A 1 112 ? 6.27434   -12.83471 15.63641 1.000 55.05488  ? 1055 PHE   A CB   1 
ATOM   1695 C  CG   . PHE   A 1 112 ? 7.43212   -13.03551 16.58226 1.000 55.16087  ? 1055 PHE   A CG   1 
ATOM   1696 C  CD1  . PHE   A 1 112 ? 7.68024   -14.26161 17.15286 1.000 65.59326  ? 1055 PHE   A CD1  1 
ATOM   1697 C  CD2  . PHE   A 1 112 ? 8.25405   -11.98195 16.92566 1.000 56.98285  ? 1055 PHE   A CD2  1 
ATOM   1698 C  CE1  . PHE   A 1 112 ? 8.73657   -14.42231 18.02928 1.000 66.03714  ? 1055 PHE   A CE1  1 
ATOM   1699 C  CE2  . PHE   A 1 112 ? 9.31075   -12.14244 17.80796 1.000 57.57194  ? 1055 PHE   A CE2  1 
ATOM   1700 C  CZ   . PHE   A 1 112 ? 9.55265   -13.35787 18.34815 1.000 58.05683  ? 1055 PHE   A CZ   1 
ATOM   1701 H  H    . PHE   A 1 112 ? 8.09066   -12.70648 13.91178 1.000 74.29204  ? 1055 PHE   A H    1 
ATOM   1702 H  HA   . PHE   A 1 112 ? 6.24030   -14.55241 14.51913 1.000 72.82191  ? 1055 PHE   A HA   1 
ATOM   1703 H  HB2  . PHE   A 1 112 ? 6.22341   -11.88807 15.43101 1.000 66.08114  ? 1055 PHE   A HB2  1 
ATOM   1704 H  HB3  . PHE   A 1 112 ? 5.46789   -13.11864 16.09457 1.000 66.08114  ? 1055 PHE   A HB3  1 
ATOM   1705 H  HD1  . PHE   A 1 112 ? 7.13455   -14.98629 16.94802 1.000 78.72718  ? 1055 PHE   A HD1  1 
ATOM   1706 H  HD2  . PHE   A 1 112 ? 8.09512   -11.14350 16.55602 1.000 68.39470  ? 1055 PHE   A HD2  1 
ATOM   1707 H  HE1  . PHE   A 1 112 ? 8.89847   -15.25634 18.40754 1.000 79.25985  ? 1055 PHE   A HE1  1 
ATOM   1708 H  HE2  . PHE   A 1 112 ? 9.85067   -11.41768 18.02727 1.000 69.10160  ? 1055 PHE   A HE2  1 
ATOM   1709 H  HZ   . PHE   A 1 112 ? 10.26658  -13.47547 18.93242 1.000 69.68347  ? 1055 PHE   A HZ   1 
ATOM   1710 N  N    . GLY   A 1 113 ? 5.56485   -13.22117 12.04770 1.000 44.32732  ? 1056 GLY   A N    1 
ATOM   1711 C  CA   . GLY   A 1 113 ? 4.55255   -12.97014 11.04252 1.000 55.93181  ? 1056 GLY   A CA   1 
ATOM   1712 C  C    . GLY   A 1 113 ? 4.74429   -11.62991 10.35384 1.000 62.20729  ? 1056 GLY   A C    1 
ATOM   1713 O  O    . GLY   A 1 113 ? 5.69910   -10.89765 10.60258 1.000 63.34514  ? 1056 GLY   A O    1 
ATOM   1714 H  H    . GLY   A 1 113 ? 6.33803   -13.40484 11.71898 1.000 53.20806  ? 1056 GLY   A H    1 
ATOM   1715 H  HA2  . GLY   A 1 113 ? 4.58771   -13.66769 10.36940 1.000 67.13344  ? 1056 GLY   A HA2  1 
ATOM   1716 H  HA3  . GLY   A 1 113 ? 3.67668   -12.97732 11.45929 1.000 67.13344  ? 1056 GLY   A HA3  1 
ATOM   1717 N  N    . ALA   A 1 114 ? 3.79877   -11.32163 9.46506  1.000 58.11481  ? 1057 ALA   A N    1 
ATOM   1718 C  CA   . ALA   A 1 114 ? 3.82707   -10.07796 8.70088  1.000 63.78520  ? 1057 ALA   A CA   1 
ATOM   1719 C  C    . ALA   A 1 114 ? 3.14707   -8.98450  9.52391  1.000 67.77973  ? 1057 ALA   A C    1 
ATOM   1720 O  O    . ALA   A 1 114 ? 1.97569   -8.65744  9.33944  1.000 62.96472  ? 1057 ALA   A O    1 
ATOM   1721 C  CB   . ALA   A 1 114 ? 3.16157   -10.26982 7.34505  1.000 63.07062  ? 1057 ALA   A CB   1 
ATOM   1722 H  H    . ALA   A 1 114 ? 3.12365   -11.82340 9.28608  1.000 69.75304  ? 1057 ALA   A H    1 
ATOM   1723 H  HA   . ALA   A 1 114 ? 4.74908   -9.81560  8.55268  1.000 76.55752  ? 1057 ALA   A HA   1 
ATOM   1724 H  HB1  . ALA   A 1 114 ? 3.20028   -9.43464  6.85324  1.000 75.70002  ? 1057 ALA   A HB1  1 
ATOM   1725 H  HB2  . ALA   A 1 114 ? 3.63293   -10.96314 6.85717  1.000 75.70002  ? 1057 ALA   A HB2  1 
ATOM   1726 H  HB3  . ALA   A 1 114 ? 2.23736   -10.53108 7.48103  1.000 75.70002  ? 1057 ALA   A HB3  1 
ATOM   1727 N  N    . GLY   A 1 115 ? 3.91277   -8.40400  10.45148 1.000 51.68625  ? 1058 GLY   A N    1 
ATOM   1728 C  CA   . GLY   A 1 115 ? 3.41926   -7.32875  11.28967 1.000 48.58674  ? 1058 GLY   A CA   1 
ATOM   1729 C  C    . GLY   A 1 115 ? 4.44988   -6.24025  11.50722 1.000 44.17329  ? 1058 GLY   A C    1 
ATOM   1730 O  O    . GLY   A 1 115 ? 5.50876   -6.26076  10.87320 1.000 38.04464  ? 1058 GLY   A O    1 
ATOM   1731 H  H    . GLY   A 1 115 ? 4.72917   -8.62229  10.61096 1.000 62.03878  ? 1058 GLY   A H    1 
ATOM   1732 H  HA2  . GLY   A 1 115 ? 2.63875   -6.93087  10.87327 1.000 58.31936  ? 1058 GLY   A HA2  1 
ATOM   1733 H  HA3  . GLY   A 1 115 ? 3.16725   -7.68743  12.15497 1.000 58.31936  ? 1058 GLY   A HA3  1 
ATOM   1734 N  N    . ILE   A 1 116 ? 4.16797   -5.28613  12.38935 1.000 42.97017  ? 1059 ILE   A N    1 
ATOM   1735 C  CA   . ILE   A 1 116 ? 5.08761   -4.18275  12.67492 1.000 44.74230  ? 1059 ILE   A CA   1 
ATOM   1736 C  C    . ILE   A 1 116 ? 5.77728   -4.47298  13.99421 1.000 37.26065  ? 1059 ILE   A C    1 
ATOM   1737 O  O    . ILE   A 1 116 ? 5.10980   -4.67503  15.01166 1.000 38.00438  ? 1059 ILE   A O    1 
ATOM   1738 C  CB   . ILE   A 1 116 ? 4.34936   -2.83509  12.73150 1.000 40.89370  ? 1059 ILE   A CB   1 
ATOM   1739 C  CG1  . ILE   A 1 116 ? 3.41343   -2.71574  11.52740 1.000 47.32167  ? 1059 ILE   A CG1  1 
ATOM   1740 C  CG2  . ILE   A 1 116 ? 5.34921   -1.67690  12.76262 1.000 41.84940  ? 1059 ILE   A CG2  1 
ATOM   1741 C  CD1  . ILE   A 1 116 ? 2.50412   -1.57538  11.60098 1.000 41.11763  ? 1059 ILE   A CD1  1 
ATOM   1742 H  H    . ILE   A 1 116 ? 3.43851   -5.25387  12.84371 1.000 51.57948  ? 1059 ILE   A H    1 
ATOM   1743 H  HA   . ILE   A 1 116 ? 5.75639   -4.13288  11.97410 1.000 53.70604  ? 1059 ILE   A HA   1 
ATOM   1744 H  HB   . ILE   A 1 116 ? 3.82187   -2.79605  13.54460 1.000 49.08771  ? 1059 ILE   A HB   1 
ATOM   1745 H  HG12 . ILE   A 1 116 ? 3.94883   -2.61637  10.72467 1.000 56.80128  ? 1059 ILE   A HG12 1 
ATOM   1746 H  HG13 . ILE   A 1 116 ? 2.87512   -3.52059  11.46962 1.000 56.80128  ? 1059 ILE   A HG13 1 
ATOM   1747 H  HG21 . ILE   A 1 116 ? 4.86135   -0.83852  12.76483 1.000 50.23456  ? 1059 ILE   A HG21 1 
ATOM   1748 H  HG22 . ILE   A 1 116 ? 5.88930   -1.74744  13.56525 1.000 50.23456  ? 1059 ILE   A HG22 1 
ATOM   1749 H  HG23 . ILE   A 1 116 ? 5.91594   -1.72776  11.97704 1.000 50.23456  ? 1059 ILE   A HG23 1 
ATOM   1750 H  HD11 . ILE   A 1 116 ? 1.91158   -1.59390  10.83323 1.000 49.35644  ? 1059 ILE   A HD11 1 
ATOM   1751 H  HD12 . ILE   A 1 116 ? 1.98705   -1.63607  12.41943 1.000 49.35644  ? 1059 ILE   A HD12 1 
ATOM   1752 H  HD13 . ILE   A 1 116 ? 3.02383   -0.75636  11.59803 1.000 49.35644  ? 1059 ILE   A HD13 1 
ATOM   1753 N  N    . TYR   A 1 117 ? 7.10730   -4.46270  13.97687 1.000 33.60436  ? 1060 TYR   A N    1 
ATOM   1754 C  CA   . TYR   A 1 117 ? 7.96857   -4.88367  15.07394 1.000 31.50399  ? 1060 TYR   A CA   1 
ATOM   1755 C  C    . TYR   A 1 117 ? 8.48455   -3.70752  15.89613 1.000 37.66588  ? 1060 TYR   A C    1 
ATOM   1756 O  O    . TYR   A 1 117 ? 8.99235   -2.72895  15.34175 1.000 37.75478  ? 1060 TYR   A O    1 
ATOM   1757 C  CB   . TYR   A 1 117 ? 9.15568   -5.66908  14.50265 1.000 37.41889  ? 1060 TYR   A CB   1 
ATOM   1758 C  CG   . TYR   A 1 117 ? 8.74502   -7.02969  14.01450 1.000 36.08901  ? 1060 TYR   A CG   1 
ATOM   1759 C  CD1  . TYR   A 1 117 ? 7.98434   -7.17513  12.88584 1.000 44.98142  ? 1060 TYR   A CD1  1 
ATOM   1760 C  CD2  . TYR   A 1 117 ? 9.08003   -8.16330  14.71716 1.000 46.98434  ? 1060 TYR   A CD2  1 
ATOM   1761 C  CE1  . TYR   A 1 117 ? 7.57360   -8.41176  12.46240 1.000 49.56862  ? 1060 TYR   A CE1  1 
ATOM   1762 C  CE2  . TYR   A 1 117 ? 8.68042   -9.40439  14.30101 1.000 47.64761  ? 1060 TYR   A CE2  1 
ATOM   1763 C  CZ   . TYR   A 1 117 ? 7.92816   -9.52234  13.17712 1.000 51.78497  ? 1060 TYR   A CZ   1 
ATOM   1764 O  OH   . TYR   A 1 117 ? 7.51111   -10.76431 12.76213 1.000 55.06611  ? 1060 TYR   A OH   1 
ATOM   1765 H  H    . TYR   A 1 117 ? 7.56172   -4.19881  13.29609 1.000 40.34051  ? 1060 TYR   A H    1 
ATOM   1766 H  HA   . TYR   A 1 117 ? 7.44746   -5.43083  15.68218 1.000 37.82007  ? 1060 TYR   A HA   1 
ATOM   1767 H  HB2  . TYR   A 1 117 ? 9.53236   -5.17893  13.75515 1.000 44.91794  ? 1060 TYR   A HB2  1 
ATOM   1768 H  HB3  . TYR   A 1 117 ? 9.82509   -5.78393  15.19518 1.000 44.91794  ? 1060 TYR   A HB3  1 
ATOM   1769 H  HD1  . TYR   A 1 117 ? 7.74209   -6.42139  12.39789 1.000 53.99298  ? 1060 TYR   A HD1  1 
ATOM   1770 H  HD2  . TYR   A 1 117 ? 9.58895   -8.08496  15.49160 1.000 56.39649  ? 1060 TYR   A HD2  1 
ATOM   1771 H  HE1  . TYR   A 1 117 ? 7.05688   -8.49532  11.69368 1.000 59.49761  ? 1060 TYR   A HE1  1 
ATOM   1772 H  HE2  . TYR   A 1 117 ? 8.92237   -10.16112 14.78446 1.000 57.19240  ? 1060 TYR   A HE2  1 
ATOM   1773 H  HH   . TYR   A 1 117 ? 6.97442   -10.68761 12.12050 1.000 66.09460  ? 1060 TYR   A HH   1 
ATOM   1774 N  N    . PHE   A 1 118 ? 8.42107   -3.84642  17.22729 1.000 35.32624  ? 1061 PHE   A N    1 
ATOM   1775 C  CA   . PHE   A 1 118 ? 8.92216   -2.87195  18.18828 1.000 39.39451  ? 1061 PHE   A CA   1 
ATOM   1776 C  C    . PHE   A 1 118 ? 9.82071   -3.56003  19.20595 1.000 41.45868  ? 1061 PHE   A C    1 
ATOM   1777 O  O    . PHE   A 1 118 ? 9.70870   -4.75950  19.44519 1.000 35.13373  ? 1061 PHE   A O    1 
ATOM   1778 C  CB   . PHE   A 1 118 ? 7.75825   -2.18566  18.92605 1.000 36.60441  ? 1061 PHE   A CB   1 
ATOM   1779 C  CG   . PHE   A 1 118 ? 6.82341   -1.45872  18.02136 1.000 36.49212  ? 1061 PHE   A CG   1 
ATOM   1780 C  CD1  . PHE   A 1 118 ? 5.84380   -2.12964  17.33811 1.000 34.48220  ? 1061 PHE   A CD1  1 
ATOM   1781 C  CD2  . PHE   A 1 118 ? 6.94528   -0.10360  17.83879 1.000 37.05771  ? 1061 PHE   A CD2  1 
ATOM   1782 C  CE1  . PHE   A 1 118 ? 4.99668   -1.46572  16.49535 1.000 33.87946  ? 1061 PHE   A CE1  1 
ATOM   1783 C  CE2  . PHE   A 1 118 ? 6.09124   0.57336   16.98279 1.000 29.66165  ? 1061 PHE   A CE2  1 
ATOM   1784 C  CZ   . PHE   A 1 118 ? 5.11275   -0.11149  16.33007 1.000 35.07891  ? 1061 PHE   A CZ   1 
ATOM   1785 H  H    . PHE   A 1 118 ? 8.07363   -4.53327  17.61085 1.000 42.40677  ? 1061 PHE   A H    1 
ATOM   1786 H  HA   . PHE   A 1 118 ? 9.44858   -2.20373  17.72215 1.000 47.28868  ? 1061 PHE   A HA   1 
ATOM   1787 H  HB2  . PHE   A 1 118 ? 7.24758   -2.86054  19.40003 1.000 43.94057  ? 1061 PHE   A HB2  1 
ATOM   1788 H  HB3  . PHE   A 1 118 ? 8.12250   -1.54295  19.55466 1.000 43.94057  ? 1061 PHE   A HB3  1 
ATOM   1789 H  HD1  . PHE   A 1 118 ? 5.75392   -3.04861  17.44905 1.000 41.39391  ? 1061 PHE   A HD1  1 
ATOM   1790 H  HD2  . PHE   A 1 118 ? 7.60741   0.36466   18.29400 1.000 44.48453  ? 1061 PHE   A HD2  1 
ATOM   1791 H  HE1  . PHE   A 1 118 ? 4.34003   -1.93493  16.03322 1.000 40.67063  ? 1061 PHE   A HE1  1 
ATOM   1792 H  HE2  . PHE   A 1 118 ? 6.18608   1.48967   16.85515 1.000 35.60925  ? 1061 PHE   A HE2  1 
ATOM   1793 H  HZ   . PHE   A 1 118 ? 4.52257   0.34072   15.77141 1.000 42.10996  ? 1061 PHE   A HZ   1 
ATOM   1794 N  N    . ALA   A 1 119 ? 10.69093  -2.77860  19.84720 1.000 32.00234  ? 1062 ALA   A N    1 
ATOM   1795 C  CA   . ALA   A 1 119 ? 11.67212  -3.31557  20.78441 1.000 33.91399  ? 1062 ALA   A CA   1 
ATOM   1796 C  C    . ALA   A 1 119 ? 11.64051  -2.58640  22.10882 1.000 29.09420  ? 1062 ALA   A C    1 
ATOM   1797 O  O    . ALA   A 1 119 ? 11.42296  -1.37833  22.16337 1.000 32.19683  ? 1062 ALA   A O    1 
ATOM   1798 C  CB   . ALA   A 1 119 ? 13.09310  -3.18993  20.24178 1.000 35.68806  ? 1062 ALA   A CB   1 
ATOM   1799 H  H    . ALA   A 1 119 ? 10.73110  -1.92469  19.75326 1.000 38.41808  ? 1062 ALA   A H    1 
ATOM   1800 H  HA   . ALA   A 1 119 ? 11.44150  -4.24554  20.93560 1.000 40.71207  ? 1062 ALA   A HA   1 
ATOM   1801 H  HB1  . ALA   A 1 119 ? 13.71470  -3.53591  20.90118 1.000 42.84094  ? 1062 ALA   A HB1  1 
ATOM   1802 H  HB2  . ALA   A 1 119 ? 13.16382  -3.70101  19.42038 1.000 42.84094  ? 1062 ALA   A HB2  1 
ATOM   1803 H  HB3  . ALA   A 1 119 ? 13.28285  -2.25487  20.06694 1.000 42.84094  ? 1062 ALA   A HB3  1 
ATOM   1804 N  N    . GLU   A 1 120 ? 11.89010  -3.32667  23.18922 1.000 40.56520  ? 1063 GLU   A N    1 
ATOM   1805 C  CA   . GLU   A 1 120 ? 12.22171  -2.65325  24.43942 1.000 42.97500  ? 1063 GLU   A CA   1 
ATOM   1806 C  C    . GLU   A 1 120 ? 13.66356  -2.14865  24.43564 1.000 41.03315  ? 1063 GLU   A C    1 
ATOM   1807 O  O    . GLU   A 1 120 ? 13.96719  -1.15569  25.09948 1.000 35.14748  ? 1063 GLU   A O    1 
ATOM   1808 C  CB   . GLU   A 1 120 ? 11.97489  -3.58346  25.62302 1.000 40.01621  ? 1063 GLU   A CB   1 
ATOM   1809 C  CG   . GLU   A 1 120 ? 10.52675  -3.58423  26.08419 1.000 42.90866  ? 1063 GLU   A CG   1 
ATOM   1810 C  CD   . GLU   A 1 120 ? 10.25215  -4.57889  27.21487 1.000 51.16545  ? 1063 GLU   A CD   1 
ATOM   1811 O  OE1  . GLU   A 1 120 ? 11.21571  -5.12060  27.79218 1.000 54.69517  ? 1063 GLU   A OE1  1 
ATOM   1812 O  OE2  . GLU   A 1 120 ? 9.06569   -4.82931  27.52858 1.000 47.35030  ? 1063 GLU   A OE2  1 
ATOM   1813 H  H    . GLU   A 1 120 ? 11.87419  -4.18591  23.22169 1.000 48.69352  ? 1063 GLU   A H    1 
ATOM   1814 H  HA   . GLU   A 1 120 ? 11.63852  -1.88678  24.55483 1.000 51.58527  ? 1063 GLU   A HA   1 
ATOM   1815 H  HB2  . GLU   A 1 120 ? 12.20781  -4.48922  25.36563 1.000 48.03473  ? 1063 GLU   A HB2  1 
ATOM   1816 H  HB3  . GLU   A 1 120 ? 12.52644  -3.29810  26.36819 1.000 48.03473  ? 1063 GLU   A HB3  1 
ATOM   1817 H  HG2  . GLU   A 1 120 ? 10.29907  -2.69783  26.40567 1.000 51.50567  ? 1063 GLU   A HG2  1 
ATOM   1818 H  HG3  . GLU   A 1 120 ? 9.95859   -3.82136  25.33461 1.000 51.50567  ? 1063 GLU   A HG3  1 
ATOM   1819 N  N    . ASN   A 1 121 ? 14.55108  -2.79812  23.68879 1.000 39.30203  ? 1064 ASN   A N    1 
ATOM   1820 C  CA   . ASN   A 1 121 ? 15.95171  -2.39481  23.59920 1.000 35.32503  ? 1064 ASN   A CA   1 
ATOM   1821 C  C    . ASN   A 1 121 ? 16.10213  -1.40846  22.45348 1.000 36.21227  ? 1064 ASN   A C    1 
ATOM   1822 O  O    . ASN   A 1 121 ? 15.91128  -1.76792  21.28612 1.000 36.37219  ? 1064 ASN   A O    1 
ATOM   1823 C  CB   . ASN   A 1 121 ? 16.84462  -3.60352  23.34940 1.000 34.92286  ? 1064 ASN   A CB   1 
ATOM   1824 C  CG   . ASN   A 1 121 ? 17.08445  -4.44400  24.57811 1.000 41.03742  ? 1064 ASN   A CG   1 
ATOM   1825 O  OD1  . ASN   A 1 121 ? 16.72175  -5.61416  24.62822 1.000 36.52570  ? 1064 ASN   A OD1  1 
ATOM   1826 N  ND2  . ASN   A 1 121 ? 17.75079  -3.87528  25.54316 1.000 39.01061  ? 1064 ASN   A ND2  1 
ATOM   1827 H  H    . ASN   A 1 121 ? 14.36273  -3.49029  23.21442 1.000 47.17771  ? 1064 ASN   A H    1 
ATOM   1828 H  HA   . ASN   A 1 121 ? 16.20893  -1.96950  24.43218 1.000 42.40532  ? 1064 ASN   A HA   1 
ATOM   1829 H  HB2  . ASN   A 1 121 ? 16.42590  -4.16863  22.68140 1.000 41.92270  ? 1064 ASN   A HB2  1 
ATOM   1830 H  HB3  . ASN   A 1 121 ? 17.70658  -3.29447  23.02938 1.000 41.92270  ? 1064 ASN   A HB3  1 
ATOM   1831 H  HD21 . ASN   A 1 121 ? 17.91531  -4.31019  26.26661 1.000 46.82801  ? 1064 ASN   A HD21 1 
ATOM   1832 H  HD22 . ASN   A 1 121 ? 18.02593  -3.06510  25.45647 1.000 46.82801  ? 1064 ASN   A HD22 1 
ATOM   1833 N  N    . SER   A 1 122 ? 16.46034  -0.16487  22.76069 1.000 31.54584  ? 1065 SER   A N    1 
ATOM   1834 C  CA   . SER   A 1 122 ? 16.69659  0.79477   21.69018 1.000 32.45538  ? 1065 SER   A CA   1 
ATOM   1835 C  C    . SER   A 1 122 ? 17.75206  0.27703   20.72352 1.000 32.91765  ? 1065 SER   A C    1 
ATOM   1836 O  O    . SER   A 1 122 ? 17.66025  0.50547   19.51797 1.000 32.26690  ? 1065 SER   A O    1 
ATOM   1837 C  CB   . SER   A 1 122 ? 17.14920  2.12102   22.28794 1.000 40.32941  ? 1065 SER   A CB   1 
ATOM   1838 O  OG   . SER   A 1 122 ? 18.42316  1.94791   22.89244 1.000 37.15397  ? 1065 SER   A OG   1 
ATOM   1839 H  H    . SER   A 1 122 ? 16.57015  0.13935   23.55755 1.000 37.87029  ? 1065 SER   A H    1 
ATOM   1840 H  HA   . SER   A 1 122 ? 15.87129  0.93730   21.20083 1.000 38.96173  ? 1065 SER   A HA   1 
ATOM   1841 H  HB2  . SER   A 1 122 ? 17.21325  2.78657   21.58520 1.000 48.41056  ? 1065 SER   A HB2  1 
ATOM   1842 H  HB3  . SER   A 1 122 ? 16.50991  2.40746   22.95888 1.000 48.41056  ? 1065 SER   A HB3  1 
ATOM   1843 H  HG   . SER   A 1 122 ? 18.63326  2.63818   23.32254 1.000 44.60004  ? 1065 SER   A HG   1 
ATOM   1844 N  N    . SER   A 1 123 ? 18.78442  -0.39481  21.23406 1.000 29.59640  ? 1066 SER   A N    1 
ATOM   1845 C  CA   . SER   A 1 123 ? 19.85441  -0.86498  20.34898 1.000 34.70029  ? 1066 SER   A CA   1 
ATOM   1846 C  C    . SER   A 1 123 ? 19.36009  -1.91003  19.37569 1.000 35.03325  ? 1066 SER   A C    1 
ATOM   1847 O  O    . SER   A 1 123 ? 19.94337  -2.06163  18.29511 1.000 33.08873  ? 1066 SER   A O    1 
ATOM   1848 C  CB   . SER   A 1 123 ? 21.03922  -1.39404  21.16292 1.000 31.29328  ? 1066 SER   A CB   1 
ATOM   1849 O  OG   . SER   A 1 123 ? 20.68254  -2.35397  22.15666 1.000 31.92508  ? 1066 SER   A OG   1 
ATOM   1850 H  H    . SER   A 1 123 ? 18.88809  -0.58711  22.06585 1.000 35.53096  ? 1066 SER   A H    1 
ATOM   1851 H  HA   . SER   A 1 123 ? 20.18701  -0.11410  19.83279 1.000 41.65562  ? 1066 SER   A HA   1 
ATOM   1852 H  HB2  . SER   A 1 123 ? 21.66482  -1.81126  20.55019 1.000 37.56721  ? 1066 SER   A HB2  1 
ATOM   1853 H  HB3  . SER   A 1 123 ? 21.46119  -0.64181  21.60675 1.000 37.56721  ? 1066 SER   A HB3  1 
ATOM   1854 H  HG   . SER   A 1 123 ? 20.19989  -2.95227  21.81802 1.000 38.32537  ? 1066 SER   A HG   1 
ATOM   1855 N  N    . LYS   A 1 124 ? 18.24975  -2.57584  19.69771 1.000 34.47176  ? 1067 LYS   A N    1 
ATOM   1856 C  CA   . LYS   A 1 124 ? 17.64117  -3.53585  18.76983 1.000 41.77362  ? 1067 LYS   A CA   1 
ATOM   1857 C  C    . LYS   A 1 124 ? 16.97749  -2.81874  17.59298 1.000 39.27795  ? 1067 LYS   A C    1 
ATOM   1858 O  O    . LYS   A 1 124 ? 17.24706  -3.13395  16.42664 1.000 34.77612  ? 1067 LYS   A O    1 
ATOM   1859 C  CB   . LYS   A 1 124 ? 16.63221  -4.41310  19.55344 1.000 40.01077  ? 1067 LYS   A CB   1 
ATOM   1860 C  CG   . LYS   A 1 124 ? 15.74586  -5.32193  18.73801 1.000 38.46738  ? 1067 LYS   A CG   1 
ATOM   1861 C  CD   . LYS   A 1 124 ? 16.47706  -6.10319  17.62396 1.000 46.57991  ? 1067 LYS   A CD   1 
ATOM   1862 C  CE   . LYS   A 1 124 ? 16.94483  -7.47528  18.04043 1.000 48.45522  ? 1067 LYS   A CE   1 
ATOM   1863 N  NZ   . LYS   A 1 124 ? 17.38455  -8.22810  16.83374 1.000 44.21969  ? 1067 LYS   A NZ   1 
ATOM   1864 H  H    . LYS   A 1 124 ? 17.82900  -2.49225  20.44309 1.000 41.38139  ? 1067 LYS   A H    1 
ATOM   1865 H  HA   . LYS   A 1 124 ? 18.32201  -4.11726  18.39656 1.000 50.14362  ? 1067 LYS   A HA   1 
ATOM   1866 H  HB2  . LYS   A 1 124 ? 17.13451  -4.97807  20.16122 1.000 48.02820  ? 1067 LYS   A HB2  1 
ATOM   1867 H  HB3  . LYS   A 1 124 ? 16.04801  -3.82323  20.05510 1.000 48.02820  ? 1067 LYS   A HB3  1 
ATOM   1868 H  HG2  . LYS   A 1 124 ? 15.33975  -5.97244  19.33200 1.000 46.17613  ? 1067 LYS   A HG2  1 
ATOM   1869 H  HG3  . LYS   A 1 124 ? 15.05820  -4.78479  18.31434 1.000 46.17613  ? 1067 LYS   A HG3  1 
ATOM   1870 H  HD2  . LYS   A 1 124 ? 15.87291  -6.21392  16.87320 1.000 55.91117  ? 1067 LYS   A HD2  1 
ATOM   1871 H  HD3  . LYS   A 1 124 ? 17.25783  -5.59716  17.34967 1.000 55.91117  ? 1067 LYS   A HD3  1 
ATOM   1872 H  HE2  . LYS   A 1 124 ? 17.69300  -7.39718  18.65284 1.000 58.16154  ? 1067 LYS   A HE2  1 
ATOM   1873 H  HE3  . LYS   A 1 124 ? 16.21776  -7.95723  18.46467 1.000 58.16154  ? 1067 LYS   A HE3  1 
ATOM   1874 H  HZ1  . LYS   A 1 124 ? 17.66973  -9.03812  17.06748 1.000 53.07891  ? 1067 LYS   A HZ1  1 
ATOM   1875 H  HZ2  . LYS   A 1 124 ? 16.70584  -8.31397  16.26446 1.000 53.07891  ? 1067 LYS   A HZ2  1 
ATOM   1876 H  HZ3  . LYS   A 1 124 ? 18.04780  -7.79400  16.42908 1.000 53.07891  ? 1067 LYS   A HZ3  1 
ATOM   1877 N  N    . SER   A 1 125 ? 16.10160  -1.85045  17.87931 1.000 36.67154  ? 1068 SER   A N    1 
ATOM   1878 C  CA   . SER   A 1 125 ? 15.56131  -1.00649  16.82320 1.000 36.18455  ? 1068 SER   A CA   1 
ATOM   1879 C  C    . SER   A 1 125 ? 16.67730  -0.34659  16.01387 1.000 33.83257  ? 1068 SER   A C    1 
ATOM   1880 O  O    . SER   A 1 125 ? 16.53241  -0.11946  14.80381 1.000 29.42549  ? 1068 SER   A O    1 
ATOM   1881 C  CB   . SER   A 1 125 ? 14.64233  0.05334   17.44645 1.000 37.49227  ? 1068 SER   A CB   1 
ATOM   1882 O  OG   . SER   A 1 125 ? 13.41788  -0.49272  17.96887 1.000 35.75799  ? 1068 SER   A OG   1 
ATOM   1883 H  H    . SER   A 1 125 ? 15.81057  -1.66743  18.66760 1.000 44.02113  ? 1068 SER   A H    1 
ATOM   1884 H  HA   . SER   A 1 125 ? 15.03329  -1.54295  16.21139 1.000 43.43674  ? 1068 SER   A HA   1 
ATOM   1885 H  HB2  . SER   A 1 125 ? 15.11998  0.48362   18.17281 1.000 45.00600  ? 1068 SER   A HB2  1 
ATOM   1886 H  HB3  . SER   A 1 125 ? 14.41985  0.70528   16.76353 1.000 45.00600  ? 1068 SER   A HB3  1 
ATOM   1887 H  HG   . SER   A 1 125 ? 12.88952  -0.66707  17.33955 1.000 42.92486  ? 1068 SER   A HG   1 
ATOM   1888 N  N    . ASN   A 1 126 ? 17.78972  -0.01902  16.65149 1.000 35.05644  ? 1069 ASN   A N    1 
ATOM   1889 C  CA   . ASN   A 1 126 ? 18.89862  0.61261   15.94296 1.000 33.99998  ? 1069 ASN   A CA   1 
ATOM   1890 C  C    . ASN   A 1 126 ? 19.40771  -0.24447  14.79655 1.000 38.24081  ? 1069 ASN   A C    1 
ATOM   1891 O  O    . ASN   A 1 126 ? 20.00016  0.27095   13.84750 1.000 37.04200  ? 1069 ASN   A O    1 
ATOM   1892 C  CB   . ASN   A 1 126 ? 20.02403  0.89270   16.93708 1.000 33.18643  ? 1069 ASN   A CB   1 
ATOM   1893 C  CG   . ASN   A 1 126 ? 21.24616  1.53705   16.27871 1.000 46.34703  ? 1069 ASN   A CG   1 
ATOM   1894 O  OD1  . ASN   A 1 126 ? 21.19327  2.68832   15.81882 1.000 31.32917  ? 1069 ASN   A OD1  1 
ATOM   1895 N  ND2  . ASN   A 1 126 ? 22.35745  0.79035   16.23851 1.000 33.10439  ? 1069 ASN   A ND2  1 
ATOM   1896 H  H    . ASN   A 1 126 ? 17.93115  -0.14923  17.48973 1.000 42.08300  ? 1069 ASN   A H    1 
ATOM   1897 H  HA   . ASN   A 1 126 ? 18.60546  1.45578   15.56347 1.000 40.81525  ? 1069 ASN   A HA   1 
ATOM   1898 H  HB2  . ASN   A 1 126 ? 19.69807  1.49745   17.62186 1.000 39.83899  ? 1069 ASN   A HB2  1 
ATOM   1899 H  HB3  . ASN   A 1 126 ? 20.30586  0.05646   17.33980 1.000 39.83899  ? 1069 ASN   A HB3  1 
ATOM   1900 H  HD21 . ASN   A 1 126 ? 23.07338  1.10382   15.87965 1.000 39.74054  ? 1069 ASN   A HD21 1 
ATOM   1901 H  HD22 . ASN   A 1 126 ? 22.35502  -0.00253  16.57157 1.000 39.74054  ? 1069 ASN   A HD22 1 
ATOM   1902 N  N    . GLN   A 1 127 ? 19.17222  -1.54904  14.85931 1.000 41.54304  ? 1070 GLN   A N    1 
ATOM   1903 C  CA   . GLN   A 1 127 ? 19.61769  -2.45019  13.81203 1.000 41.01292  ? 1070 GLN   A CA   1 
ATOM   1904 C  C    . GLN   A 1 127 ? 18.81809  -2.31952  12.52639 1.000 33.53202  ? 1070 GLN   A C    1 
ATOM   1905 O  O    . GLN   A 1 127 ? 19.27204  -2.79615  11.48915 1.000 37.48730  ? 1070 GLN   A O    1 
ATOM   1906 C  CB   . GLN   A 1 127 ? 19.52212  -3.90619  14.30068 1.000 31.98478  ? 1070 GLN   A CB   1 
ATOM   1907 C  CG   . GLN   A 1 127 ? 20.42932  -4.27407  15.47418 1.000 33.10812  ? 1070 GLN   A CG   1 
ATOM   1908 C  CD   . GLN   A 1 127 ? 20.41915  -5.78798  15.75728 1.000 41.32907  ? 1070 GLN   A CD   1 
ATOM   1909 O  OE1  . GLN   A 1 127 ? 19.36920  -6.40748  15.75225 1.000 48.16579  ? 1070 GLN   A OE1  1 
ATOM   1910 N  NE2  . GLN   A 1 127 ? 21.58879  -6.37105  15.96941 1.000 38.75996  ? 1070 GLN   A NE2  1 
ATOM   1911 H  H    . GLN   A 1 127 ? 18.75397  -1.93821  15.50213 1.000 49.86692  ? 1070 GLN   A H    1 
ATOM   1912 H  HA   . GLN   A 1 127 ? 20.54263  -2.23584  13.61344 1.000 49.23078  ? 1070 GLN   A HA   1 
ATOM   1913 H  HB2  . GLN   A 1 127 ? 18.60846  -4.07368  14.58009 1.000 38.39701  ? 1070 GLN   A HB2  1 
ATOM   1914 H  HB3  . GLN   A 1 127 ? 19.75572  -4.49050  13.56251 1.000 38.39701  ? 1070 GLN   A HB3  1 
ATOM   1915 H  HG2  . GLN   A 1 127 ? 21.33979  -4.01000  15.26877 1.000 39.74502  ? 1070 GLN   A HG2  1 
ATOM   1916 H  HG3  . GLN   A 1 127 ? 20.12236  -3.81435  16.27126 1.000 39.74502  ? 1070 GLN   A HG3  1 
ATOM   1917 H  HE21 . GLN   A 1 127 ? 22.31174  -5.90588  15.94566 1.000 46.52722  ? 1070 GLN   A HE21 1 
ATOM   1918 H  HE22 . GLN   A 1 127 ? 21.62557  -7.21494  16.13095 1.000 46.52722  ? 1070 GLN   A HE22 1 
ATOM   1919 N  N    . TYR   A 1 128 ? 17.61000  -1.76245  12.56836 1.000 30.73292  ? 1071 TYR   A N    1 
ATOM   1920 C  CA   . TYR   A 1 128 ? 16.77397  -1.60781  11.38006 1.000 36.46623  ? 1071 TYR   A CA   1 
ATOM   1921 C  C    . TYR   A 1 128 ? 16.70830  -0.16869  10.87385 1.000 39.11189  ? 1071 TYR   A C    1 
ATOM   1922 O  O    . TYR   A 1 128 ? 15.93494  0.12636   9.96438  1.000 38.69185  ? 1071 TYR   A O    1 
ATOM   1923 C  CB   . TYR   A 1 128 ? 15.36958  -2.14788  11.68659 1.000 42.17138  ? 1071 TYR   A CB   1 
ATOM   1924 C  CG   . TYR   A 1 128 ? 15.43130  -3.61218  12.11133 1.000 45.16927  ? 1071 TYR   A CG   1 
ATOM   1925 C  CD1  . TYR   A 1 128 ? 15.72554  -3.96954  13.43340 1.000 44.02413  ? 1071 TYR   A CD1  1 
ATOM   1926 C  CD2  . TYR   A 1 128 ? 15.26595  -4.63335  11.18367 1.000 42.48595  ? 1071 TYR   A CD2  1 
ATOM   1927 C  CE1  . TYR   A 1 128 ? 15.80789  -5.29958  13.82189 1.000 45.90371  ? 1071 TYR   A CE1  1 
ATOM   1928 C  CE2  . TYR   A 1 128 ? 15.35444  -5.97277  11.56840 1.000 45.36543  ? 1071 TYR   A CE2  1 
ATOM   1929 C  CZ   . TYR   A 1 128 ? 15.62096  -6.29241  12.88586 1.000 44.40677  ? 1071 TYR   A CZ   1 
ATOM   1930 O  OH   . TYR   A 1 128 ? 15.71336  -7.60219  13.29036 1.000 55.07029  ? 1071 TYR   A OH   1 
ATOM   1931 H  H    . TYR   A 1 128 ? 17.24600  -1.46076  13.28676 1.000 36.89478  ? 1071 TYR   A H    1 
ATOM   1932 H  HA   . TYR   A 1 128 ? 17.15136  -2.13028  10.65515 1.000 43.77475  ? 1071 TYR   A HA   1 
ATOM   1933 H  HB2  . TYR   A 1 128 ? 14.97633  -1.63364  12.40895 1.000 50.62093  ? 1071 TYR   A HB2  1 
ATOM   1934 H  HB3  . TYR   A 1 128 ? 14.81705  -2.08031  10.89220 1.000 50.62093  ? 1071 TYR   A HB3  1 
ATOM   1935 H  HD1  . TYR   A 1 128 ? 15.86877  -3.30144  14.06430 1.000 52.84424  ? 1071 TYR   A HD1  1 
ATOM   1936 H  HD2  . TYR   A 1 128 ? 15.09402  -4.42190  10.29450 1.000 50.99841  ? 1071 TYR   A HD2  1 
ATOM   1937 H  HE1  . TYR   A 1 128 ? 15.98794  -5.51865  14.70760 1.000 55.09973  ? 1071 TYR   A HE1  1 
ATOM   1938 H  HE2  . TYR   A 1 128 ? 15.23435  -6.64756  10.93980 1.000 54.45379  ? 1071 TYR   A HE2  1 
ATOM   1939 H  HH   . TYR   A 1 128 ? 15.52026  -8.11403  12.65293 1.000 66.09962  ? 1071 TYR   A HH   1 
ATOM   1940 N  N    . VAL   A 1 129 ? 17.49141  0.74060   11.43216 1.000 32.94162  ? 1072 VAL   A N    1 
ATOM   1941 C  CA   . VAL   A 1 129 ? 17.45817  2.11443   10.93729 1.000 41.61383  ? 1072 VAL   A CA   1 
ATOM   1942 C  C    . VAL   A 1 129 ? 17.79128  2.14546   9.45520  1.000 39.33612  ? 1072 VAL   A C    1 
ATOM   1943 O  O    . VAL   A 1 129 ? 17.13945  2.83681   8.67105  1.000 41.48107  ? 1072 VAL   A O    1 
ATOM   1944 C  CB   . VAL   A 1 129 ? 18.41115  2.98063   11.77045 1.000 41.01436  ? 1072 VAL   A CB   1 
ATOM   1945 C  CG1  . VAL   A 1 129 ? 18.75809  4.21846   11.05894 1.000 48.62968  ? 1072 VAL   A CG1  1 
ATOM   1946 C  CG2  . VAL   A 1 129 ? 17.72516  3.32847   13.04153 1.000 41.40595  ? 1072 VAL   A CG2  1 
ATOM   1947 H  H    . VAL   A 1 129 ? 18.03736  0.59672   12.08087 1.000 39.54522  ? 1072 VAL   A H    1 
ATOM   1948 H  HA   . VAL   A 1 129 ? 16.56331  2.47499   11.03793 1.000 49.95187  ? 1072 VAL   A HA   1 
ATOM   1949 H  HB   . VAL   A 1 129 ? 19.23131  2.49112   11.93964 1.000 49.23251  ? 1072 VAL   A HB   1 
ATOM   1950 H  HG11 . VAL   A 1 129 ? 19.18339  4.83079   11.67947 1.000 58.37089  ? 1072 VAL   A HG11 1 
ATOM   1951 H  HG12 . VAL   A 1 129 ? 19.36682  4.00612   10.33420 1.000 58.37089  ? 1072 VAL   A HG12 1 
ATOM   1952 H  HG13 . VAL   A 1 129 ? 17.94775  4.61663   10.70437 1.000 58.37089  ? 1072 VAL   A HG13 1 
ATOM   1953 H  HG21 . VAL   A 1 129 ? 18.34128  3.81714   13.60943 1.000 49.70242  ? 1072 VAL   A HG21 1 
ATOM   1954 H  HG22 . VAL   A 1 129 ? 16.95146  3.87864   12.84253 1.000 49.70242  ? 1072 VAL   A HG22 1 
ATOM   1955 H  HG23 . VAL   A 1 129 ? 17.44530  2.51146   13.48319 1.000 49.70242  ? 1072 VAL   A HG23 1 
ATOM   1956 N  N    . TYR   A 1 130 ? 18.76712  1.34852   9.03579  1.000 41.80500  ? 1073 TYR   A N    1 
ATOM   1957 C  CA   . TYR   A 1 130 ? 19.18644  1.27570   7.64296  1.000 37.91344  ? 1073 TYR   A CA   1 
ATOM   1958 C  C    . TYR   A 1 130 ? 18.63892  0.04389   6.92608  1.000 41.58244  ? 1073 TYR   A C    1 
ATOM   1959 O  O    . TYR   A 1 130 ? 19.19139  -0.37078  5.89999  1.000 37.10673  ? 1073 TYR   A O    1 
ATOM   1960 C  CB   . TYR   A 1 130 ? 20.70847  1.30525   7.58312  1.000 38.12611  ? 1073 TYR   A CB   1 
ATOM   1961 C  CG   . TYR   A 1 130 ? 21.29907  2.61388   8.08217  1.000 37.09876  ? 1073 TYR   A CG   1 
ATOM   1962 C  CD1  . TYR   A 1 130 ? 20.83960  3.82194   7.59687  1.000 36.12447  ? 1073 TYR   A CD1  1 
ATOM   1963 C  CD2  . TYR   A 1 130 ? 22.30457  2.64217   9.04181  1.000 37.55627  ? 1073 TYR   A CD2  1 
ATOM   1964 C  CE1  . TYR   A 1 130 ? 21.40759  5.06976   8.02992  1.000 39.88216  ? 1073 TYR   A CE1  1 
ATOM   1965 C  CE2  . TYR   A 1 130 ? 22.86665  3.87034   9.48704  1.000 40.23177  ? 1073 TYR   A CE2  1 
ATOM   1966 C  CZ   . TYR   A 1 130 ? 22.40482  5.07961   8.97354  1.000 37.61420  ? 1073 TYR   A CZ   1 
ATOM   1967 O  OH   . TYR   A 1 130 ? 22.92290  6.31267   9.38033  1.000 44.28227  ? 1073 TYR   A OH   1 
ATOM   1968 H  H    . TYR   A 1 130 ? 19.21296  0.82660   9.55389  1.000 50.18128  ? 1073 TYR   A H    1 
ATOM   1969 H  HA   . TYR   A 1 130 ? 18.84466  2.04829   7.16632  1.000 45.51141  ? 1073 TYR   A HA   1 
ATOM   1970 H  HB2  . TYR   A 1 130 ? 21.05887  0.58914   8.13567  1.000 45.76660  ? 1073 TYR   A HB2  1 
ATOM   1971 H  HB3  . TYR   A 1 130 ? 20.98946  1.18210   6.66292  1.000 45.76660  ? 1073 TYR   A HB3  1 
ATOM   1972 H  HD1  . TYR   A 1 130 ? 20.14724  3.82873   6.97600  1.000 43.36464  ? 1073 TYR   A HD1  1 
ATOM   1973 H  HD2  . TYR   A 1 130 ? 22.61577  1.84218   9.39968  1.000 45.08280  ? 1073 TYR   A HD2  1 
ATOM   1974 H  HE1  . TYR   A 1 130 ? 21.09944  5.87036   7.67078  1.000 47.87387  ? 1073 TYR   A HE1  1 
ATOM   1975 H  HE2  . TYR   A 1 130 ? 23.54493  3.86589   10.12329 1.000 48.29339  ? 1073 TYR   A HE2  1 
ATOM   1976 H  HH   . TYR   A 1 130 ? 23.55360  6.19456   9.92243  1.000 53.15400  ? 1073 TYR   A HH   1 
ATOM   1977 N  N    . GLY   A 1 131 ? 17.55579  -0.52808  7.43219  1.000 37.82050  ? 1074 GLY   A N    1 
ATOM   1978 C  CA   . GLY   A 1 131 ? 16.87196  -1.63195  6.76924  1.000 40.88947  ? 1074 GLY   A CA   1 
ATOM   1979 C  C    . GLY   A 1 131 ? 17.14183  -2.96663  7.43974  1.000 42.12044  ? 1074 GLY   A C    1 
ATOM   1980 O  O    . GLY   A 1 131 ? 17.76735  -3.06753  8.49910  1.000 41.79512  ? 1074 GLY   A O    1 
ATOM   1981 H  H    . GLY   A 1 131 ? 17.18889  -0.29132  8.17309  1.000 45.39987  ? 1074 GLY   A H    1 
ATOM   1982 H  HA2  . GLY   A 1 131 ? 15.91546  -1.47126  6.78255  1.000 49.08264  ? 1074 GLY   A HA2  1 
ATOM   1983 H  HA3  . GLY   A 1 131 ? 17.17012  -1.68714  5.84785  1.000 49.08264  ? 1074 GLY   A HA3  1 
ATOM   1984 N  N    . ILE   A 1 132 ? 16.64613  -4.01995  6.79399  1.000 45.42012  ? 1075 ILE   A N    1 
ATOM   1985 C  CA   . ILE   A 1 132 ? 16.86321  -5.37645  7.28057  1.000 41.44487  ? 1075 ILE   A CA   1 
ATOM   1986 C  C    . ILE   A 1 132 ? 18.35042  -5.62927  7.45686  1.000 34.68164  ? 1075 ILE   A C    1 
ATOM   1987 O  O    . ILE   A 1 132 ? 19.13104  -5.49866  6.51274  1.000 38.65003  ? 1075 ILE   A O    1 
ATOM   1988 C  CB   . ILE   A 1 132 ? 16.28157  -6.40633  6.29954  1.000 41.06784  ? 1075 ILE   A CB   1 
ATOM   1989 C  CG1  . ILE   A 1 132 ? 14.77027  -6.27120  6.11915  1.000 53.29894  ? 1075 ILE   A CG1  1 
ATOM   1990 C  CG2  . ILE   A 1 132 ? 16.56083  -7.80721  6.79538  1.000 54.18885  ? 1075 ILE   A CG2  1 
ATOM   1991 C  CD1  . ILE   A 1 132 ? 13.99443  -6.52583  7.36176  1.000 51.64566  ? 1075 ILE   A CD1  1 
ATOM   1992 H  H    . ILE   A 1 132 ? 16.18089  -3.97526  6.07208  1.000 54.51942  ? 1075 ILE   A H    1 
ATOM   1993 H  HA   . ILE   A 1 132 ? 16.41475  -5.45585  8.13700  1.000 49.74912  ? 1075 ILE   A HA   1 
ATOM   1994 H  HB   . ILE   A 1 132 ? 16.71092  -6.23463  5.44685  1.000 49.29669  ? 1075 ILE   A HB   1 
ATOM   1995 H  HG12 . ILE   A 1 132 ? 14.57060  -5.36871  5.82498  1.000 63.97400  ? 1075 ILE   A HG12 1 
ATOM   1996 H  HG13 . ILE   A 1 132 ? 14.47741  -6.91039  5.45088  1.000 63.97400  ? 1075 ILE   A HG13 1 
ATOM   1997 H  HG21 . ILE   A 1 132 ? 15.94331  -8.42201  6.36925  1.000 65.04190  ? 1075 ILE   A HG21 1 
ATOM   1998 H  HG22 . ILE   A 1 132 ? 17.47359  -8.04589  6.56999  1.000 65.04190  ? 1075 ILE   A HG22 1 
ATOM   1999 H  HG23 . ILE   A 1 132 ? 16.44058  -7.83147  7.75760  1.000 65.04190  ? 1075 ILE   A HG23 1 
ATOM   2000 H  HD11 . ILE   A 1 132 ? 13.05209  -6.58417  7.13932  1.000 61.99007  ? 1075 ILE   A HD11 1 
ATOM   2001 H  HD12 . ILE   A 1 132 ? 14.29365  -7.36032  7.75546  1.000 61.99007  ? 1075 ILE   A HD12 1 
ATOM   2002 H  HD13 . ILE   A 1 132 ? 14.14323  -5.79525  7.98225  1.000 61.99007  ? 1075 ILE   A HD13 1 
ATOM   2003 N  N    . GLY   A 1 133 ? 18.73357  -6.05527  8.64437  1.000 36.98179  ? 1076 GLY   A N    1 
ATOM   2004 C  CA   . GLY   A 1 133 ? 20.08712  -6.48466  8.87448  1.000 37.13266  ? 1076 GLY   A CA   1 
ATOM   2005 C  C    . GLY   A 1 133 ? 21.06217  -5.35645  8.91493  1.000 44.03880  ? 1076 GLY   A C    1 
ATOM   2006 O  O    . GLY   A 1 133 ? 22.27336  -5.59337  8.85395  1.000 41.27058  ? 1076 GLY   A O    1 
ATOM   2007 H  H    . GLY   A 1 133 ? 18.22296  -6.10409  9.33466  1.000 44.39343  ? 1076 GLY   A H    1 
ATOM   2008 H  HA2  . GLY   A 1 133 ? 20.13122  -6.95390  9.72228  1.000 44.57447  ? 1076 GLY   A HA2  1 
ATOM   2009 H  HA3  . GLY   A 1 133 ? 20.35298  -7.08970  8.16445  1.000 44.57447  ? 1076 GLY   A HA3  1 
ATOM   2010 N  N    . GLY   A 1 134 ? 20.56157  -4.12780  9.01712  1.000 43.05366  ? 1077 GLY   A N    1 
ATOM   2011 C  CA   . GLY   A 1 134 ? 21.40006  -2.96518  8.86154  1.000 47.25225  ? 1077 GLY   A CA   1 
ATOM   2012 C  C    . GLY   A 1 134 ? 21.62061  -2.57244  7.42792  1.000 44.92612  ? 1077 GLY   A C    1 
ATOM   2013 O  O    . GLY   A 1 134 ? 22.36757  -1.62292  7.18131  1.000 41.36188  ? 1077 GLY   A O    1 
ATOM   2014 H  H    . GLY   A 1 134 ? 19.73538  -3.95030  9.17683  1.000 51.67967  ? 1077 GLY   A H    1 
ATOM   2015 H  HA2  . GLY   A 1 134 ? 20.98889  -2.21563  9.31981  1.000 56.71798  ? 1077 GLY   A HA2  1 
ATOM   2016 H  HA3  . GLY   A 1 134 ? 22.26533  -3.14397  9.26186  1.000 56.71798  ? 1077 GLY   A HA3  1 
ATOM   2017 N  N    . GLY   A 1 135 ? 20.97284  -3.26600  6.48765  1.000 46.92992  ? 1078 GLY   A N    1 
ATOM   2018 C  CA   . GLY   A 1 135 ? 21.15706  -3.01288  5.07249  1.000 41.57744  ? 1078 GLY   A CA   1 
ATOM   2019 C  C    . GLY   A 1 135 ? 22.62093  -2.89281  4.73847  1.000 46.63574  ? 1078 GLY   A C    1 
ATOM   2020 O  O    . GLY   A 1 135 ? 23.45117  -3.70369  5.16937  1.000 44.07963  ? 1078 GLY   A O    1 
ATOM   2021 H  H    . GLY   A 1 135 ? 20.41305  -3.89781  6.65212  1.000 56.33118  ? 1078 GLY   A H    1 
ATOM   2022 H  HA2  . GLY   A 1 135 ? 20.77778  -3.74180  4.55701  1.000 49.90821  ? 1078 GLY   A HA2  1 
ATOM   2023 H  HA3  . GLY   A 1 135 ? 20.71175  -2.18698  4.82652  1.000 49.90821  ? 1078 GLY   A HA3  1 
ATOM   2024 N  N    . THR   A 1 136 ? 22.93820  -1.83931  3.98145  1.000 51.09895  ? 1079 THR   A N    1 
ATOM   2025 C  CA   . THR   A 1 136 ? 24.29160  -1.46919  3.60530  1.000 53.75966  ? 1079 THR   A CA   1 
ATOM   2026 C  C    . THR   A 1 136 ? 24.84866  -0.33177  4.44657  1.000 58.05443  ? 1079 THR   A C    1 
ATOM   2027 O  O    . THR   A 1 136 ? 25.88341  0.24908   4.08213  1.000 53.43045  ? 1079 THR   A O    1 
ATOM   2028 C  CB   . THR   A 1 136 ? 24.31088  -1.06567  2.14223  1.000 52.04338  ? 1079 THR   A CB   1 
ATOM   2029 O  OG1  . THR   A 1 136 ? 23.39106  0.01718   1.93929  1.000 48.21646  ? 1079 THR   A OG1  1 
ATOM   2030 C  CG2  . THR   A 1 136 ? 23.87224  -2.20671  1.31723  1.000 41.18223  ? 1079 THR   A CG2  1 
ATOM   2031 H  H    . THR   A 1 136 ? 22.35115  -1.29931  3.65993  1.000 61.33402  ? 1079 THR   A H    1 
ATOM   2032 H  HA   . THR   A 1 136 ? 24.86885  -2.23866  3.73023  1.000 64.52686  ? 1079 THR   A HA   1 
ATOM   2033 H  HB   . THR   A 1 136 ? 25.20488  -0.79494  1.88077  1.000 62.46733  ? 1079 THR   A HB   1 
ATOM   2034 H  HG1  . THR   A 1 136 ? 23.18194  0.06816   1.12734  1.000 57.87503  ? 1079 THR   A HG1  1 
ATOM   2035 H  HG21 . THR   A 1 136 ? 23.93851  -1.98065  0.37627  1.000 49.43396  ? 1079 THR   A HG21 1 
ATOM   2036 H  HG22 . THR   A 1 136 ? 24.43109  -2.97924  1.49550  1.000 49.43396  ? 1079 THR   A HG22 1 
ATOM   2037 H  HG23 . THR   A 1 136 ? 22.95109  -2.43029  1.52316  1.000 49.43396  ? 1079 THR   A HG23 1 
ATOM   2038 N  N    . GLY   A 1 137 ? 24.18857  0.00364   5.55272  1.000 40.90804  ? 1080 GLY   A N    1 
ATOM   2039 C  CA   . GLY   A 1 137 ? 24.68833  1.02541   6.42759  1.000 44.69888  ? 1080 GLY   A CA   1 
ATOM   2040 C  C    . GLY   A 1 137 ? 24.25942  2.39962   5.94562  1.000 45.63674  ? 1080 GLY   A C    1 
ATOM   2041 O  O    . GLY   A 1 137 ? 23.35185  2.56194   5.11199  1.000 46.15093  ? 1080 GLY   A O    1 
ATOM   2042 H  H    . GLY   A 1 137 ? 23.44909  -0.35312  5.80866  1.000 49.10492  ? 1080 GLY   A H    1 
ATOM   2043 H  HA2  . GLY   A 1 137 ? 24.34441  0.88661   7.32389  1.000 53.65393  ? 1080 GLY   A HA2  1 
ATOM   2044 H  HA3  . GLY   A 1 137 ? 25.65739  0.99071   6.45229  1.000 53.65393  ? 1080 GLY   A HA3  1 
ATOM   2045 N  N    . CYS   A 1 138 ? 24.96240  3.40507   6.45683  1.000 36.51991  ? 1081 CYS   A N    1 
ATOM   2046 C  CA   . CYS   A 1 138 ? 24.57823  4.79067   6.18193  1.000 45.66644  ? 1081 CYS   A CA   1 
ATOM   2047 C  C    . CYS   A 1 138 ? 24.65989  5.12430   4.69080  1.000 43.56115  ? 1081 CYS   A C    1 
ATOM   2048 O  O    . CYS   A 1 138 ? 25.50151  4.59668   3.96325  1.000 50.19183  ? 1081 CYS   A O    1 
ATOM   2049 C  CB   . CYS   A 1 138 ? 25.46627  5.74718   6.96896  1.000 41.82927  ? 1081 CYS   A CB   1 
ATOM   2050 S  SG   . CYS   A 1 138 ? 27.17417  5.67012   6.52134  1.000 48.76738  ? 1081 CYS   A SG   1 
ATOM   2051 H  H    . CYS   A 1 138 ? 25.65545  3.31687   6.95833  1.000 43.83916  ? 1081 CYS   A H    1 
ATOM   2052 H  HA   . CYS   A 1 138 ? 23.65461  4.91055   6.45294  1.000 54.81500  ? 1081 CYS   A HA   1 
ATOM   2053 H  HB2  . CYS   A 1 138 ? 25.16057  6.65458   6.81374  1.000 50.21040  ? 1081 CYS   A HB2  1 
ATOM   2054 H  HB3  . CYS   A 1 138 ? 25.39771  5.53075   7.91202  1.000 50.21040  ? 1081 CYS   A HB3  1 
ATOM   2055 N  N    . PRO   A 1 139 ? 23.79803  6.01165   4.20452  1.000 49.58803  ? 1082 PRO   A N    1 
ATOM   2056 C  CA   . PRO   A 1 139 ? 23.88747  6.42568   2.79337  1.000 48.40026  ? 1082 PRO   A CA   1 
ATOM   2057 C  C    . PRO   A 1 139 ? 25.24807  6.94775   2.34401  1.000 48.57136  ? 1082 PRO   A C    1 
ATOM   2058 O  O    . PRO   A 1 139 ? 25.65525  6.71268   1.20514  1.000 50.18812  ? 1082 PRO   A O    1 
ATOM   2059 C  CB   . PRO   A 1 139 ? 22.83154  7.52660   2.70852  1.000 49.58124  ? 1082 PRO   A CB   1 
ATOM   2060 C  CG   . PRO   A 1 139 ? 21.82879  7.12877   3.66862  1.000 52.84154  ? 1082 PRO   A CG   1 
ATOM   2061 C  CD   . PRO   A 1 139 ? 22.55706  6.49118   4.82859  1.000 50.42554  ? 1082 PRO   A CD   1 
ATOM   2062 H  HA   . PRO   A 1 139 ? 23.65197  5.66626   2.23775  1.000 58.09559  ? 1082 PRO   A HA   1 
ATOM   2063 H  HB2  . PRO   A 1 139 ? 23.22228  8.38248   2.94448  1.000 59.51276  ? 1082 PRO   A HB2  1 
ATOM   2064 H  HB3  . PRO   A 1 139 ? 22.46223  7.56624   1.81245  1.000 59.51276  ? 1082 PRO   A HB3  1 
ATOM   2065 H  HG2  . PRO   A 1 139 ? 21.33763  7.91099   3.96492  1.000 63.42513  ? 1082 PRO   A HG2  1 
ATOM   2066 H  HG3  . PRO   A 1 139 ? 21.22286  6.49267   3.25737  1.000 63.42513  ? 1082 PRO   A HG3  1 
ATOM   2067 H  HD2  . PRO   A 1 139 ? 22.74572  7.14326   5.52147  1.000 60.52592  ? 1082 PRO   A HD2  1 
ATOM   2068 H  HD3  . PRO   A 1 139 ? 22.04578  5.75389   5.19722  1.000 60.52592  ? 1082 PRO   A HD3  1 
ATOM   2069 N  N    . VAL   A 1 140 ? 25.95445  7.66223   3.20788  1.000 49.60490  ? 1083 VAL   A N    1 
ATOM   2070 C  CA   . VAL   A 1 140 ? 27.13348  8.40077   2.77405  1.000 58.54729  ? 1083 VAL   A CA   1 
ATOM   2071 C  C    . VAL   A 1 140 ? 28.36794  7.51827   2.74399  1.000 58.12946  ? 1083 VAL   A C    1 
ATOM   2072 O  O    . VAL   A 1 140 ? 29.19552  7.62898   1.83477  1.000 62.39708  ? 1083 VAL   A O    1 
ATOM   2073 C  CB   . VAL   A 1 140 ? 27.33922  9.62090   3.69171  1.000 55.34478  ? 1083 VAL   A CB   1 
ATOM   2074 C  CG1  . VAL   A 1 140 ? 28.81773  10.07399  3.68132  1.000 44.41772  ? 1083 VAL   A CG1  1 
ATOM   2075 C  CG2  . VAL   A 1 140 ? 26.34627  10.72598  3.28590  1.000 58.60220  ? 1083 VAL   A CG2  1 
ATOM   2076 H  H    . VAL   A 1 140 ? 25.77538  7.73689   4.04571  1.000 59.54116  ? 1083 VAL   A H    1 
ATOM   2077 H  HA   . VAL   A 1 140 ? 26.98162  8.70941   1.86708  1.000 70.27202  ? 1083 VAL   A HA   1 
ATOM   2078 H  HB   . VAL   A 1 140 ? 27.15129  9.39450   4.61601  1.000 66.42901  ? 1083 VAL   A HB   1 
ATOM   2079 H  HG11 . VAL   A 1 140 ? 28.90002  10.89502  4.19127  1.000 53.31655  ? 1083 VAL   A HG11 1 
ATOM   2080 H  HG12 . VAL   A 1 140 ? 29.36366  9.37955   4.08210  1.000 53.31655  ? 1083 VAL   A HG12 1 
ATOM   2081 H  HG13 . VAL   A 1 140 ? 29.09532  10.22498  2.76424  1.000 53.31655  ? 1083 VAL   A HG13 1 
ATOM   2082 H  HG21 . VAL   A 1 140 ? 26.45339  11.48202  3.88409  1.000 70.33792  ? 1083 VAL   A HG21 1 
ATOM   2083 H  HG22 . VAL   A 1 140 ? 26.53154  10.99742  2.37327  1.000 70.33792  ? 1083 VAL   A HG22 1 
ATOM   2084 H  HG23 . VAL   A 1 140 ? 25.44304  10.37830  3.35069  1.000 70.33792  ? 1083 VAL   A HG23 1 
ATOM   2085 N  N    . HIS   A 1 141 ? 28.54264  6.67922   3.75684  1.000 50.33961  ? 1084 HIS   A N    1 
ATOM   2086 C  CA   . HIS   A 1 141 ? 29.72992  5.86816   3.88797  1.000 49.32777  ? 1084 HIS   A CA   1 
ATOM   2087 C  C    . HIS   A 1 141 ? 29.46757  4.39269   3.65452  1.000 45.54010  ? 1084 HIS   A C    1 
ATOM   2088 O  O    . HIS   A 1 141 ? 30.42819  3.62157   3.59694  1.000 50.09124  ? 1084 HIS   A O    1 
ATOM   2089 C  CB   . HIS   A 1 141 ? 30.34296  6.02355   5.29056  1.000 52.68229  ? 1084 HIS   A CB   1 
ATOM   2090 C  CG   . HIS   A 1 141 ? 30.58314  7.43725   5.69812  1.000 53.76199  ? 1084 HIS   A CG   1 
ATOM   2091 N  ND1  . HIS   A 1 141 ? 29.63114  8.19953   6.33532  1.000 55.66792  ? 1084 HIS   A ND1  1 
ATOM   2092 C  CD2  . HIS   A 1 141 ? 31.67326  8.22507   5.56614  1.000 58.18956  ? 1084 HIS   A CD2  1 
ATOM   2093 C  CE1  . HIS   A 1 141 ? 30.12174  9.40298   6.56764  1.000 59.24844  ? 1084 HIS   A CE1  1 
ATOM   2094 N  NE2  . HIS   A 1 141 ? 31.35797  9.44528   6.10397  1.000 52.48169  ? 1084 HIS   A NE2  1 
ATOM   2095 H  H    . HIS   A 1 141 ? 27.97265  6.56404   4.39044  1.000 60.42281  ? 1084 HIS   A H    1 
ATOM   2096 H  HA   . HIS   A 1 141 ? 30.37952  6.17909   3.23817  1.000 59.20860  ? 1084 HIS   A HA   1 
ATOM   2097 H  HB2  . HIS   A 1 141 ? 29.73881  5.62892   5.93877  1.000 63.23402  ? 1084 HIS   A HB2  1 
ATOM   2098 H  HB3  . HIS   A 1 141 ? 31.19636  5.56283   5.30903  1.000 63.23402  ? 1084 HIS   A HB3  1 
ATOM   2099 H  HD2  . HIS   A 1 141 ? 32.48532  7.98416   5.18219  1.000 69.84274  ? 1084 HIS   A HD2  1 
ATOM   2100 H  HE1  . HIS   A 1 141 ? 29.67337  10.10192  6.98639  1.000 71.11340  ? 1084 HIS   A HE1  1 
ATOM   2101 H  HE2  . HIS   A 1 141 ? 31.88017  10.12789  6.13468  1.000 62.99330  ? 1084 HIS   A HE2  1 
ATOM   2102 N  N    . LYS   A 1 142 ? 28.20689  3.98338   3.54528  1.000 44.02334  ? 1085 LYS   A N    1 
ATOM   2103 C  CA   . LYS   A 1 142 ? 27.82349  2.56799   3.54722  1.000 51.19299  ? 1085 LYS   A CA   1 
ATOM   2104 C  C    . LYS   A 1 142 ? 28.42258  1.85080   4.75198  1.000 46.02923  ? 1085 LYS   A C    1 
ATOM   2105 O  O    . LYS   A 1 142 ? 29.00835  0.77755   4.63287  1.000 43.42193  ? 1085 LYS   A O    1 
ATOM   2106 C  CB   . LYS   A 1 142 ? 28.24389  1.85739   2.26091  1.000 46.94667  ? 1085 LYS   A CB   1 
ATOM   2107 C  CG   . LYS   A 1 142 ? 28.29764  2.71272   0.99083  1.000 57.44378  ? 1085 LYS   A CG   1 
ATOM   2108 C  CD   . LYS   A 1 142 ? 27.09244  2.54985   0.11697  1.000 77.47953  ? 1085 LYS   A CD   1 
ATOM   2109 C  CE   . LYS   A 1 142 ? 27.47400  2.57898   -1.34165 1.000 87.49175  ? 1085 LYS   A CE   1 
ATOM   2110 N  NZ   . LYS   A 1 142 ? 26.25038  2.36592   -2.16941 1.000 84.79823  ? 1085 LYS   A NZ   1 
ATOM   2111 H  H    . LYS   A 1 142 ? 27.53691  4.51683   3.46677  1.000 52.84329  ? 1085 LYS   A H    1 
ATOM   2112 H  HA   . LYS   A 1 142 ? 26.85592  2.53139   3.60517  1.000 61.44686  ? 1085 LYS   A HA   1 
ATOM   2113 H  HB2  . LYS   A 1 142 ? 29.13262  1.49275   2.39547  1.000 56.35128  ? 1085 LYS   A HB2  1 
ATOM   2114 H  HB3  . LYS   A 1 142 ? 27.61279  1.14002   2.09361  1.000 56.35128  ? 1085 LYS   A HB3  1 
ATOM   2115 H  HG2  . LYS   A 1 142 ? 28.35785  3.64736   1.24328  1.000 68.94781  ? 1085 LYS   A HG2  1 
ATOM   2116 H  HG3  . LYS   A 1 142 ? 29.07721  2.45810   0.47282  1.000 68.94781  ? 1085 LYS   A HG3  1 
ATOM   2117 H  HD2  . LYS   A 1 142 ? 26.66871  1.69810   0.30637  1.000 92.99072  ? 1085 LYS   A HD2  1 
ATOM   2118 H  HD3  . LYS   A 1 142 ? 26.47042  3.27470   0.28599  1.000 92.99072  ? 1085 LYS   A HD3  1 
ATOM   2119 H  HE2  . LYS   A 1 142 ? 27.85982  3.44043   -1.56515 1.000 105.00538 ? 1085 LYS   A HE2  1 
ATOM   2120 H  HE3  . LYS   A 1 142 ? 28.10995  1.87145   -1.53105 1.000 105.00538 ? 1085 LYS   A HE3  1 
ATOM   2121 H  HZ1  . LYS   A 1 142 ? 26.45474  2.41887   -3.03401 1.000 101.77315 ? 1085 LYS   A HZ1  1 
ATOM   2122 H  HZ2  . LYS   A 1 142 ? 25.90620  1.56228   -2.00266 1.000 101.77315 ? 1085 LYS   A HZ2  1 
ATOM   2123 H  HZ3  . LYS   A 1 142 ? 25.64157  2.98625   -1.97800 1.000 101.77315 ? 1085 LYS   A HZ3  1 
ATOM   2124 N  N    . ASP   A 1 143 ? 28.29334  2.46626   5.92785  1.000 43.98279  ? 1086 ASP   A N    1 
ATOM   2125 C  CA   . ASP   A 1 143 ? 28.92579  1.95837   7.13436  1.000 38.19097  ? 1086 ASP   A CA   1 
ATOM   2126 C  C    . ASP   A 1 143 ? 27.84370  1.71006   8.17236  1.000 49.15417  ? 1086 ASP   A C    1 
ATOM   2127 O  O    . ASP   A 1 143 ? 27.22548  2.65448   8.68604  1.000 39.44271  ? 1086 ASP   A O    1 
ATOM   2128 C  CB   . ASP   A 1 143 ? 29.99174  2.91901   7.63532  1.000 37.59506  ? 1086 ASP   A CB   1 
ATOM   2129 C  CG   . ASP   A 1 143 ? 30.76655  2.35333   8.81494  1.000 46.16373  ? 1086 ASP   A CG   1 
ATOM   2130 O  OD1  . ASP   A 1 143 ? 30.35428  1.26790   9.27421  1.000 37.83962  ? 1086 ASP   A OD1  1 
ATOM   2131 O  OD2  . ASP   A 1 143 ? 31.75354  2.99473   9.29890  1.000 38.62284  ? 1086 ASP   A OD2  1 
ATOM   2132 H  H    . ASP   A 1 143 ? 27.83868  3.18640   6.04743  1.000 52.79462  ? 1086 ASP   A H    1 
ATOM   2133 H  HA   . ASP   A 1 143 ? 29.35695  1.10947   6.94895  1.000 45.84444  ? 1086 ASP   A HA   1 
ATOM   2134 H  HB2  . ASP   A 1 143 ? 30.62047  3.09847   6.91881  1.000 45.12935  ? 1086 ASP   A HB2  1 
ATOM   2135 H  HB3  . ASP   A 1 143 ? 29.56829  3.74413   7.91954  1.000 45.12935  ? 1086 ASP   A HB3  1 
ATOM   2136 N  N    . ARG   A 1 144 ? 27.59263  0.42813   8.45230  1.000 43.15369  ? 1087 ARG   A N    1 
ATOM   2137 C  CA   . ARG   A 1 144 ? 26.55705  0.05477   9.39749  1.000 43.72663  ? 1087 ARG   A CA   1 
ATOM   2138 C  C    . ARG   A 1 144 ? 26.91795  0.50530   10.79909 1.000 42.31692  ? 1087 ARG   A C    1 
ATOM   2139 O  O    . ARG   A 1 144 ? 26.03440  0.62677   11.65317 1.000 33.54149  ? 1087 ARG   A O    1 
ATOM   2140 C  CB   . ARG   A 1 144 ? 26.33363  -1.46916  9.35880  1.000 39.72854  ? 1087 ARG   A CB   1 
ATOM   2141 C  CG   . ARG   A 1 144 ? 25.41329  -1.93038  8.22720  1.000 43.44641  ? 1087 ARG   A CG   1 
ATOM   2142 C  CD   . ARG   A 1 144 ? 25.07734  -3.43543  8.30163  1.000 46.49724  ? 1087 ARG   A CD   1 
ATOM   2143 N  NE   . ARG   A 1 144 ? 26.27157  -4.23986  8.10971  1.000 40.48937  ? 1087 ARG   A NE   1 
ATOM   2144 C  CZ   . ARG   A 1 144 ? 26.76755  -4.59359  6.93166  1.000 43.65848  ? 1087 ARG   A CZ   1 
ATOM   2145 N  NH1  . ARG   A 1 144 ? 26.15468  -4.28545  5.79421  1.000 43.27529  ? 1087 ARG   A NH1  1 
ATOM   2146 N  NH2  . ARG   A 1 144 ? 27.89970  -5.28138  6.89558  1.000 47.60025  ? 1087 ARG   A NH2  1 
ATOM   2147 H  H    . ARG   A 1 144 ? 28.01076  -0.23858  8.10552  1.000 51.79971  ? 1087 ARG   A H    1 
ATOM   2148 H  HA   . ARG   A 1 144 ? 25.71691  0.47136   9.14946  1.000 52.48723  ? 1087 ARG   A HA   1 
ATOM   2149 H  HB2  . ARG   A 1 144 ? 27.19107  -1.90679  9.23973  1.000 47.68952  ? 1087 ARG   A HB2  1 
ATOM   2150 H  HB3  . ARG   A 1 144 ? 25.93316  -1.74668  10.19755 1.000 47.68952  ? 1087 ARG   A HB3  1 
ATOM   2151 H  HG2  . ARG   A 1 144 ? 24.58046  -1.43546  8.27571  1.000 52.15097  ? 1087 ARG   A HG2  1 
ATOM   2152 H  HG3  . ARG   A 1 144 ? 25.84954  -1.76317  7.37713  1.000 52.15097  ? 1087 ARG   A HG3  1 
ATOM   2153 H  HD2  . ARG   A 1 144 ? 24.70391  -3.64123  9.17289  1.000 55.81196  ? 1087 ARG   A HD2  1 
ATOM   2154 H  HD3  . ARG   A 1 144 ? 24.43964  -3.65973  7.60597  1.000 55.81196  ? 1087 ARG   A HD3  1 
ATOM   2155 H  HE   . ARG   A 1 144 ? 26.68838  -4.50684  8.81298  1.000 48.60252  ? 1087 ARG   A HE   1 
ATOM   2156 H  HH11 . ARG   A 1 144 ? 25.41608  -3.84518  5.80930  1.000 51.94562  ? 1087 ARG   A HH11 1 
ATOM   2157 H  HH12 . ARG   A 1 144 ? 26.49648  -4.52622  5.04267  1.000 51.94562  ? 1087 ARG   A HH12 1 
ATOM   2158 H  HH21 . ARG   A 1 144 ? 28.29929  -5.49055  7.62782  1.000 57.13558  ? 1087 ARG   A HH21 1 
ATOM   2159 H  HH22 . ARG   A 1 144 ? 28.23483  -5.51858  6.13992  1.000 57.13558  ? 1087 ARG   A HH22 1 
ATOM   2160 N  N    . SER   A 1 145 ? 28.20579  0.72639   11.04802 1.000 35.56399  ? 1088 SER   A N    1 
ATOM   2161 C  CA   . SER   A 1 145 ? 28.69321  1.24323   12.31264 1.000 39.70669  ? 1088 SER   A CA   1 
ATOM   2162 C  C    . SER   A 1 145 ? 29.10880  2.70973   12.21029 1.000 37.43521  ? 1088 SER   A C    1 
ATOM   2163 O  O    . SER   A 1 145 ? 29.97030  3.15386   12.95758 1.000 37.17281  ? 1088 SER   A O    1 
ATOM   2164 C  CB   . SER   A 1 145 ? 29.87602  0.42277   12.79494 1.000 40.86406  ? 1088 SER   A CB   1 
ATOM   2165 O  OG   . SER   A 1 145 ? 30.14942  0.66017   14.16689 1.000 40.37722  ? 1088 SER   A OG   1 
ATOM   2166 H  H    . SER   A 1 145 ? 28.83269  0.57829   10.47822 1.000 42.69206  ? 1088 SER   A H    1 
ATOM   2167 H  HA   . SER   A 1 145 ? 27.97539  1.17498   12.96147 1.000 47.66331  ? 1088 SER   A HA   1 
ATOM   2168 H  HB2  . SER   A 1 145 ? 29.67424  -0.51831  12.67423 1.000 49.05214  ? 1088 SER   A HB2  1 
ATOM   2169 H  HB3  . SER   A 1 145 ? 30.65768  0.66399   12.27367 1.000 49.05214  ? 1088 SER   A HB3  1 
ATOM   2170 H  HG   . SER   A 1 145 ? 30.37816  1.46048   14.27996 1.000 48.46794  ? 1088 SER   A HG   1 
ATOM   2171 N  N    . CYS   A 1 146 ? 28.52215  3.46792   11.28804 1.000 43.02978  ? 1089 CYS   A N    1 
ATOM   2172 C  CA   . CYS   A 1 146 ? 28.91359  4.87031   11.15146 1.000 43.38709  ? 1089 CYS   A CA   1 
ATOM   2173 C  C    . CYS   A 1 146 ? 28.73602  5.60682   12.47255 1.000 46.15864  ? 1089 CYS   A C    1 
ATOM   2174 O  O    . CYS   A 1 146 ? 27.66578  5.55570   13.09394 1.000 40.03660  ? 1089 CYS   A O    1 
ATOM   2175 C  CB   . CYS   A 1 146 ? 28.09527  5.54471   10.06618 1.000 38.88420  ? 1089 CYS   A CB   1 
ATOM   2176 S  SG   . CYS   A 1 146 ? 28.79919  7.17225   9.57207  1.000 42.67777  ? 1089 CYS   A SG   1 
ATOM   2177 H  H    . CYS   A 1 146 ? 27.91152  3.20347   10.74326 1.000 51.65101  ? 1089 CYS   A H    1 
ATOM   2178 H  HA   . CYS   A 1 146 ? 29.84895  4.91288   10.89809 1.000 52.07979  ? 1089 CYS   A HA   1 
ATOM   2179 H  HB2  . CYS   A 1 146 ? 28.07494  4.97337   9.28256  1.000 46.67631  ? 1089 CYS   A HB2  1 
ATOM   2180 H  HB3  . CYS   A 1 146 ? 27.19393  5.69158   10.39316 1.000 46.67631  ? 1089 CYS   A HB3  1 
ATOM   2181 N  N    . TYR   A 1 147 ? 29.80158  6.28409   12.91241 1.000 45.81965  ? 1090 TYR   A N    1 
ATOM   2182 C  CA   . TYR   A 1 147 ? 29.75485  7.16185   14.07710 1.000 42.17943  ? 1090 TYR   A CA   1 
ATOM   2183 C  C    . TYR   A 1 147 ? 29.54234  8.62242   13.70543 1.000 49.07062  ? 1090 TYR   A C    1 
ATOM   2184 O  O    . TYR   A 1 147 ? 29.40827  9.46388   14.60589 1.000 44.61976  ? 1090 TYR   A O    1 
ATOM   2185 C  CB   . TYR   A 1 147 ? 31.03204  7.02501   14.88507 1.000 39.69253  ? 1090 TYR   A CB   1 
ATOM   2186 C  CG   . TYR   A 1 147 ? 31.26216  5.63365   15.34762 1.000 43.58808  ? 1090 TYR   A CG   1 
ATOM   2187 C  CD1  . TYR   A 1 147 ? 30.55093  5.12273   16.40301 1.000 44.05661  ? 1090 TYR   A CD1  1 
ATOM   2188 C  CD2  . TYR   A 1 147 ? 32.18388  4.81577   14.71756 1.000 49.06967  ? 1090 TYR   A CD2  1 
ATOM   2189 C  CE1  . TYR   A 1 147 ? 30.74634  3.85958   16.82816 1.000 41.43871  ? 1090 TYR   A CE1  1 
ATOM   2190 C  CE2  . TYR   A 1 147 ? 32.39156  3.53107   15.14524 1.000 42.78586  ? 1090 TYR   A CE2  1 
ATOM   2191 C  CZ   . TYR   A 1 147 ? 31.67710  3.06665   16.20140 1.000 41.34631  ? 1090 TYR   A CZ   1 
ATOM   2192 O  OH   . TYR   A 1 147 ? 31.86278  1.77777   16.62982 1.000 50.61551  ? 1090 TYR   A OH   1 
ATOM   2193 H  H    . TYR   A 1 147 ? 30.57710  6.24807   12.54244 1.000 54.99886  ? 1090 TYR   A H    1 
ATOM   2194 H  HA   . TYR   A 1 147 ? 29.01493  6.88735   14.64107 1.000 50.63060  ? 1090 TYR   A HA   1 
ATOM   2195 H  HB2  . TYR   A 1 147 ? 31.78562  7.28846   14.33406 1.000 47.64631  ? 1090 TYR   A HB2  1 
ATOM   2196 H  HB3  . TYR   A 1 147 ? 30.97601  7.59742   15.66616 1.000 47.64631  ? 1090 TYR   A HB3  1 
ATOM   2197 H  HD1  . TYR   A 1 147 ? 29.92292  5.65752   16.83255 1.000 52.88321  ? 1090 TYR   A HD1  1 
ATOM   2198 H  HD2  . TYR   A 1 147 ? 32.66861  5.14267   13.99433 1.000 58.89888  ? 1090 TYR   A HD2  1 
ATOM   2199 H  HE1  . TYR   A 1 147 ? 30.25350  3.52570   17.54268 1.000 49.74172  ? 1090 TYR   A HE1  1 
ATOM   2200 H  HE2  . TYR   A 1 147 ? 33.01239  2.98575   14.71853 1.000 51.35831  ? 1090 TYR   A HE2  1 
ATOM   2201 H  HH   . TYR   A 1 147 ? 31.29522  1.58617   17.21868 1.000 60.75388  ? 1090 TYR   A HH   1 
ATOM   2202 N  N    . ILE   A 1 148 ? 29.47554  8.91958   12.40360 1.000 43.73937  ? 1091 ILE   A N    1 
ATOM   2203 C  CA   . ILE   A 1 148 ? 29.33850  10.26117  11.87083 1.000 44.22170  ? 1091 ILE   A CA   1 
ATOM   2204 C  C    . ILE   A 1 148 ? 27.88315  10.56982  11.56368 1.000 43.36241  ? 1091 ILE   A C    1 
ATOM   2205 O  O    . ILE   A 1 148 ? 27.33669  11.56583  12.02924 1.000 40.62178  ? 1091 ILE   A O    1 
ATOM   2206 C  CB   . ILE   A 1 148 ? 30.18957  10.40631  10.59747 1.000 49.06924  ? 1091 ILE   A CB   1 
ATOM   2207 C  CG1  . ILE   A 1 148 ? 31.66872  10.28286  10.92668 1.000 42.43034  ? 1091 ILE   A CG1  1 
ATOM   2208 C  CG2  . ILE   A 1 148 ? 29.91767  11.72562  9.91980  1.000 54.30130  ? 1091 ILE   A CG2  1 
ATOM   2209 C  CD1  . ILE   A 1 148 ? 32.48975  10.03005  9.72302  1.000 58.20729  ? 1091 ILE   A CD1  1 
ATOM   2210 H  H    . ILE   A 1 148 ? 29.50993  8.32484   11.78335 1.000 52.50252  ? 1091 ILE   A H    1 
ATOM   2211 H  HA   . ILE   A 1 148 ? 29.63364  10.89310  12.54497 1.000 53.08132  ? 1091 ILE   A HA   1 
ATOM   2212 H  HB   . ILE   A 1 148 ? 29.94362  9.68972   9.99174  1.000 58.89837  ? 1091 ILE   A HB   1 
ATOM   2213 H  HG12 . ILE   A 1 148 ? 31.97394  11.10897  11.33322 1.000 50.93168  ? 1091 ILE   A HG12 1 
ATOM   2214 H  HG13 . ILE   A 1 148 ? 31.79697  9.54347   11.54131 1.000 50.93168  ? 1091 ILE   A HG13 1 
ATOM   2215 H  HG21 . ILE   A 1 148 ? 30.63890  11.91684  9.29998  1.000 65.17683  ? 1091 ILE   A HG21 1 
ATOM   2216 H  HG22 . ILE   A 1 148 ? 29.07642  11.66698  9.44047  1.000 65.17683  ? 1091 ILE   A HG22 1 
ATOM   2217 H  HG23 . ILE   A 1 148 ? 29.86686  12.42197  10.59316 1.000 65.17683  ? 1091 ILE   A HG23 1 
ATOM   2218 H  HD11 . ILE   A 1 148 ? 33.38302  9.77128   9.99869  1.000 69.86403  ? 1091 ILE   A HD11 1 
ATOM   2219 H  HD12 . ILE   A 1 148 ? 32.08289  9.31623   9.20744  1.000 69.86403  ? 1091 ILE   A HD12 1 
ATOM   2220 H  HD13 . ILE   A 1 148 ? 32.52933  10.84068  9.19178  1.000 69.86403  ? 1091 ILE   A HD13 1 
ATOM   2221 N  N    . CYS   A 1 149 ? 27.26357  9.74278   10.73972 1.000 36.75839  ? 1092 CYS   A N    1 
ATOM   2222 C  CA   . CYS   A 1 149 ? 25.97051  10.08898  10.19431 1.000 47.90610  ? 1092 CYS   A CA   1 
ATOM   2223 C  C    . CYS   A 1 149 ? 24.91800  10.02475  11.28771 1.000 42.77566  ? 1092 CYS   A C    1 
ATOM   2224 O  O    . CYS   A 1 149 ? 24.95337  9.16477   12.17116 1.000 41.04753  ? 1092 CYS   A O    1 
ATOM   2225 C  CB   . CYS   A 1 149 ? 25.59886  9.16057   9.04015  1.000 54.61840  ? 1092 CYS   A CB   1 
ATOM   2226 S  SG   . CYS   A 1 149 ? 26.50830  9.38319   7.48936  1.000 48.37838  ? 1092 CYS   A SG   1 
ATOM   2227 H  H    . CYS   A 1 149 ? 27.57005  8.98107   10.48387 1.000 44.12534  ? 1092 CYS   A H    1 
ATOM   2228 H  HA   . CYS   A 1 149 ? 25.99760  10.99142  9.83968  1.000 57.50260  ? 1092 CYS   A HA   1 
ATOM   2229 H  HB2  . CYS   A 1 149 ? 25.75070  8.24713   9.32906  1.000 65.55735  ? 1092 CYS   A HB2  1 
ATOM   2230 H  HB3  . CYS   A 1 149 ? 24.65922  9.29311   8.83914  1.000 65.55735  ? 1092 CYS   A HB3  1 
ATOM   2231 N  N    . HIS   A 1 150 ? 23.99160  10.96732  11.21305 1.000 48.39388  ? 1093 HIS   A N    1 
ATOM   2232 C  CA   . HIS   A 1 150 ? 22.88380  11.06045  12.13924 1.000 41.78045  ? 1093 HIS   A CA   1 
ATOM   2233 C  C    . HIS   A 1 150 ? 21.85838  9.96868   11.83999 1.000 43.89282  ? 1093 HIS   A C    1 
ATOM   2234 O  O    . HIS   A 1 150 ? 21.62323  9.61624   10.68814 1.000 49.36007  ? 1093 HIS   A O    1 
ATOM   2235 C  CB   . HIS   A 1 150 ? 22.24993  12.44853  12.00962 1.000 46.39338  ? 1093 HIS   A CB   1 
ATOM   2236 C  CG   . HIS   A 1 150 ? 23.11044  13.56279  12.52136 1.000 53.20526  ? 1093 HIS   A CG   1 
ATOM   2237 N  ND1  . HIS   A 1 150 ? 22.71459  14.88042  12.48188 1.000 56.39982  ? 1093 HIS   A ND1  1 
ATOM   2238 C  CD2  . HIS   A 1 150 ? 24.33370  13.55344  13.10676 1.000 54.89631  ? 1093 HIS   A CD2  1 
ATOM   2239 C  CE1  . HIS   A 1 150 ? 23.65797  15.63492  13.02094 1.000 60.15689  ? 1093 HIS   A CE1  1 
ATOM   2240 N  NE2  . HIS   A 1 150 ? 24.64929  14.85435  13.41051 1.000 53.68993  ? 1093 HIS   A NE2  1 
ATOM   2241 H  H    . HIS   A 1 150 ? 23.98337  11.58464  10.61435 1.000 58.08793  ? 1093 HIS   A H    1 
ATOM   2242 H  HA   . HIS   A 1 150 ? 23.18460  10.93984  13.05350 1.000 50.15182  ? 1093 HIS   A HA   1 
ATOM   2243 H  HB2  . HIS   A 1 150 ? 22.06995  12.62167  11.07232 1.000 55.68733  ? 1093 HIS   A HB2  1 
ATOM   2244 H  HB3  . HIS   A 1 150 ? 21.42157  12.46021  12.51418 1.000 55.68733  ? 1093 HIS   A HB3  1 
ATOM   2245 H  HD2  . HIS   A 1 150 ? 24.86060  12.80505  13.27168 1.000 65.89084  ? 1093 HIS   A HD2  1 
ATOM   2246 H  HE1  . HIS   A 1 150 ? 23.62806  16.56011  13.11056 1.000 72.20354  ? 1093 HIS   A HE1  1 
ATOM   2247 H  HE2  . HIS   A 1 150 ? 25.37369  15.11778  13.79191 1.000 64.44319  ? 1093 HIS   A HE2  1 
ATOM   2248 N  N    . ARG   A 1 151 ? 21.24391  9.44543   12.89281 1.000 34.72853  ? 1094 ARG   A N    1 
ATOM   2249 C  CA   . ARG   A 1 151 ? 20.24393  8.40290   12.80592 1.000 36.69483  ? 1094 ARG   A CA   1 
ATOM   2250 C  C    . ARG   A 1 151 ? 18.97804  8.87473   13.50308 1.000 37.28831  ? 1094 ARG   A C    1 
ATOM   2251 O  O    . ARG   A 1 151 ? 19.02085  9.71989   14.39443 1.000 37.68498  ? 1094 ARG   A O    1 
ATOM   2252 C  CB   . ARG   A 1 151 ? 20.73571  7.12323   13.46994 1.000 30.69574  ? 1094 ARG   A CB   1 
ATOM   2253 C  CG   . ARG   A 1 151 ? 21.99233  6.56139   12.92172 1.000 36.59205  ? 1094 ARG   A CG   1 
ATOM   2254 C  CD   . ARG   A 1 151 ? 22.39686  5.30029   13.67233 1.000 35.91881  ? 1094 ARG   A CD   1 
ATOM   2255 N  NE   . ARG   A 1 151 ? 23.76176  4.91598   13.32695 1.000 31.88832  ? 1094 ARG   A NE   1 
ATOM   2256 C  CZ   . ARG   A 1 151 ? 24.18600  3.66453   13.26132 1.000 37.99203  ? 1094 ARG   A CZ   1 
ATOM   2257 N  NH1  . ARG   A 1 151 ? 23.38233  2.65349   13.53866 1.000 35.84480  ? 1094 ARG   A NH1  1 
ATOM   2258 N  NH2  . ARG   A 1 151 ? 25.43893  3.42117   12.88834 1.000 42.97600  ? 1094 ARG   A NH2  1 
ATOM   2259 H  H    . ARG   A 1 151 ? 21.39947  9.69203   13.70188 1.000 41.68951  ? 1094 ARG   A H    1 
ATOM   2260 H  HA   . ARG   A 1 151 ? 20.04346  8.21144   11.87637 1.000 44.04908  ? 1094 ARG   A HA   1 
ATOM   2261 H  HB2  . ARG   A 1 151 ? 20.88775  7.30667   14.41022 1.000 36.85016  ? 1094 ARG   A HB2  1 
ATOM   2262 H  HB3  . ARG   A 1 151 ? 20.04918  6.44514   13.37099 1.000 36.85016  ? 1094 ARG   A HB3  1 
ATOM   2263 H  HG2  . ARG   A 1 151 ? 21.86490  6.33517   11.98711 1.000 43.92573  ? 1094 ARG   A HG2  1 
ATOM   2264 H  HG3  . ARG   A 1 151 ? 22.70447  7.21391   13.01101 1.000 43.92573  ? 1094 ARG   A HG3  1 
ATOM   2265 H  HD2  . ARG   A 1 151 ? 22.35360  5.46276   14.62764 1.000 43.11785  ? 1094 ARG   A HD2  1 
ATOM   2266 H  HD3  . ARG   A 1 151 ? 21.80075  4.57379   13.43203 1.000 43.11785  ? 1094 ARG   A HD3  1 
ATOM   2267 H  HE   . ARG   A 1 151 ? 24.32564  5.54224   13.15533 1.000 38.28126  ? 1094 ARG   A HE   1 
ATOM   2268 H  HH11 . ARG   A 1 151 ? 22.56670  2.80262   13.76695 1.000 43.02904  ? 1094 ARG   A HH11 1 
ATOM   2269 H  HH12 . ARG   A 1 151 ? 23.67474  1.84614   13.49092 1.000 43.02904  ? 1094 ARG   A HH12 1 
ATOM   2270 H  HH21 . ARG   A 1 151 ? 25.96387  4.07374   12.69292 1.000 51.58647  ? 1094 ARG   A HH21 1 
ATOM   2271 H  HH22 . ARG   A 1 151 ? 25.72433  2.61120   12.84253 1.000 51.58647  ? 1094 ARG   A HH22 1 
ATOM   2272 N  N    . GLN   A 1 152 ? 17.86090  8.27502   13.13577 1.000 36.36120  ? 1095 GLN   A N    1 
ATOM   2273 C  CA   . GLN   A 1 152 ? 16.59551  8.53241   13.81095 1.000 35.74450  ? 1095 GLN   A CA   1 
ATOM   2274 C  C    . GLN   A 1 152 ? 15.91472  7.23131   14.21862 1.000 43.51451  ? 1095 GLN   A C    1 
ATOM   2275 O  O    . GLN   A 1 152 ? 15.89540  6.25851   13.46012 1.000 40.37709  ? 1095 GLN   A O    1 
ATOM   2276 C  CB   . GLN   A 1 152 ? 15.69669  9.34701   12.89735 1.000 44.10277  ? 1095 GLN   A CB   1 
ATOM   2277 C  CG   . GLN   A 1 152 ? 16.25866  10.71005  12.69656 1.000 42.59427  ? 1095 GLN   A CG   1 
ATOM   2278 C  CD   . GLN   A 1 152 ? 15.39904  11.59998  11.86867 1.000 40.29874  ? 1095 GLN   A CD   1 
ATOM   2279 O  OE1  . GLN   A 1 152 ? 14.85540  11.19533  10.84637 1.000 39.15090  ? 1095 GLN   A OE1  1 
ATOM   2280 N  NE2  . GLN   A 1 152 ? 15.27989  12.85235  12.30877 1.000 45.43096  ? 1095 GLN   A NE2  1 
ATOM   2281 H  H    . GLN   A 1 152 ? 17.80614  7.70802   12.49147 1.000 43.64872  ? 1095 GLN   A H    1 
ATOM   2282 H  HA   . GLN   A 1 152 ? 16.75002  9.01926   14.63557 1.000 42.90867  ? 1095 GLN   A HA   1 
ATOM   2283 H  HB2  . GLN   A 1 152 ? 15.62875  8.90931   12.03439 1.000 52.93861  ? 1095 GLN   A HB2  1 
ATOM   2284 H  HB3  . GLN   A 1 152 ? 14.81693  9.43007   13.29739 1.000 52.93861  ? 1095 GLN   A HB3  1 
ATOM   2285 H  HG2  . GLN   A 1 152 ? 16.37182  11.13143  13.56290 1.000 51.12840  ? 1095 GLN   A HG2  1 
ATOM   2286 H  HG3  . GLN   A 1 152 ? 17.11687  10.63106  12.25143 1.000 51.12840  ? 1095 GLN   A HG3  1 
ATOM   2287 H  HE21 . GLN   A 1 152 ? 15.68603  13.09639  13.02647 1.000 54.53243  ? 1095 GLN   A HE21 1 
ATOM   2288 H  HE22 . GLN   A 1 152 ? 14.79687  13.41642  11.87505 1.000 54.53243  ? 1095 GLN   A HE22 1 
ATOM   2289 N  N    . LEU   A 1 153 ? 15.37030  7.24025   15.44188 1.000 39.83775  ? 1096 LEU   A N    1 
ATOM   2290 C  CA   . LEU   A 1 153 ? 14.47724  6.22089   15.96241 1.000 43.13998  ? 1096 LEU   A CA   1 
ATOM   2291 C  C    . LEU   A 1 153 ? 13.17578  6.88100   16.37304 1.000 44.78825  ? 1096 LEU   A C    1 
ATOM   2292 O  O    . LEU   A 1 153 ? 13.16159  8.05174   16.76764 1.000 35.83650  ? 1096 LEU   A O    1 
ATOM   2293 C  CB   . LEU   A 1 153 ? 15.00667  5.54851   17.22977 1.000 43.19301  ? 1096 LEU   A CB   1 
ATOM   2294 C  CG   . LEU   A 1 153 ? 16.13651  4.55617   17.15756 1.000 49.63634  ? 1096 LEU   A CG   1 
ATOM   2295 C  CD1  . LEU   A 1 153 ? 16.41617  4.00528   18.51851 1.000 47.90883  ? 1096 LEU   A CD1  1 
ATOM   2296 C  CD2  . LEU   A 1 153 ? 15.69153  3.49983   16.23331 1.000 56.07677  ? 1096 LEU   A CD2  1 
ATOM   2297 H  H    . LEU   A 1 153 ? 15.51703  7.86532   16.01403 1.000 47.82057  ? 1096 LEU   A H    1 
ATOM   2298 H  HA   . LEU   A 1 153 ? 14.35625  5.55419   15.26831 1.000 51.78326  ? 1096 LEU   A HA   1 
ATOM   2299 H  HB2  . LEU   A 1 153 ? 15.30978  6.25543   17.82078 1.000 51.84689  ? 1096 LEU   A HB2  1 
ATOM   2300 H  HB3  . LEU   A 1 153 ? 14.26168  5.07579   17.63278 1.000 51.84689  ? 1096 LEU   A HB3  1 
ATOM   2301 H  HG   . LEU   A 1 153 ? 16.96359  4.95410   16.84374 1.000 59.57889  ? 1096 LEU   A HG   1 
ATOM   2302 H  HD11 . LEU   A 1 153 ? 17.32309  3.66185   18.53995 1.000 57.50587  ? 1096 LEU   A HD11 1 
ATOM   2303 H  HD12 . LEU   A 1 153 ? 16.31532  4.71409   19.17297 1.000 57.50587  ? 1096 LEU   A HD12 1 
ATOM   2304 H  HD13 . LEU   A 1 153 ? 15.78737  3.29069   18.70528 1.000 57.50587  ? 1096 LEU   A HD13 1 
ATOM   2305 H  HD21 . LEU   A 1 153 ? 16.28529  2.73725   16.31589 1.000 67.30740  ? 1096 LEU   A HD21 1 
ATOM   2306 H  HD22 . LEU   A 1 153 ? 14.78564  3.24012   16.46316 1.000 67.30740  ? 1096 LEU   A HD22 1 
ATOM   2307 H  HD23 . LEU   A 1 153 ? 15.71733  3.84244   15.32620 1.000 67.30740  ? 1096 LEU   A HD23 1 
ATOM   2308 N  N    . LEU   A 1 154 ? 12.10592  6.10034   16.35231 1.000 32.90279  ? 1097 LEU   A N    1 
ATOM   2309 C  CA   . LEU   A 1 154 ? 10.84997  6.49660   16.97730 1.000 33.53810  ? 1097 LEU   A CA   1 
ATOM   2310 C  C    . LEU   A 1 154 ? 10.72265  5.83645   18.34220 1.000 38.90845  ? 1097 LEU   A C    1 
ATOM   2311 O  O    . LEU   A 1 154 ? 11.09190  4.66898   18.52226 1.000 42.37828  ? 1097 LEU   A O    1 
ATOM   2312 C  CB   . LEU   A 1 154 ? 9.66270   6.11727   16.11056 1.000 35.36903  ? 1097 LEU   A CB   1 
ATOM   2313 C  CG   . LEU   A 1 154 ? 9.60658   6.67877   14.69832 1.000 33.94061  ? 1097 LEU   A CG   1 
ATOM   2314 C  CD1  . LEU   A 1 154 ? 8.49136   6.05667   13.92587 1.000 42.55285  ? 1097 LEU   A CD1  1 
ATOM   2315 C  CD2  . LEU   A 1 154 ? 9.40665   8.16928   14.76401 1.000 39.85619  ? 1097 LEU   A CD2  1 
ATOM   2316 H  H    . LEU   A 1 154 ? 12.08083  5.32644   15.97808 1.000 39.49863  ? 1097 LEU   A H    1 
ATOM   2317 H  HA   . LEU   A 1 154 ? 10.84026  7.45930   17.09573 1.000 40.26099  ? 1097 LEU   A HA   1 
ATOM   2318 H  HB2  . LEU   A 1 154 ? 9.65472   5.15087   16.02740 1.000 42.45811  ? 1097 LEU   A HB2  1 
ATOM   2319 H  HB3  . LEU   A 1 154 ? 8.85900   6.41798   16.56282 1.000 42.45811  ? 1097 LEU   A HB3  1 
ATOM   2320 H  HG   . LEU   A 1 154 ? 10.43840  6.48100   14.24021 1.000 40.74401  ? 1097 LEU   A HG   1 
ATOM   2321 H  HD11 . LEU   A 1 154 ? 8.47340   6.43830   13.03428 1.000 51.07869  ? 1097 LEU   A HD11 1 
ATOM   2322 H  HD12 . LEU   A 1 154 ? 8.63929   5.09947   13.87304 1.000 51.07869  ? 1097 LEU   A HD12 1 
ATOM   2323 H  HD13 . LEU   A 1 154 ? 7.65346   6.23732   14.37995 1.000 51.07869  ? 1097 LEU   A HD13 1 
ATOM   2324 H  HD21 . LEU   A 1 154 ? 9.34586   8.51983   13.86162 1.000 47.84270  ? 1097 LEU   A HD21 1 
ATOM   2325 H  HD22 . LEU   A 1 154 ? 8.58705   8.35696   15.24769 1.000 47.84270  ? 1097 LEU   A HD22 1 
ATOM   2326 H  HD23 . LEU   A 1 154 ? 10.16120  8.56915   15.22408 1.000 47.84270  ? 1097 LEU   A HD23 1 
ATOM   2327 N  N    . PHE   A 1 155 ? 10.23461  6.59690   19.30498 1.000 36.98894  ? 1098 PHE   A N    1 
ATOM   2328 C  CA   . PHE   A 1 155 ? 9.79758   6.09172   20.60208 1.000 29.67999  ? 1098 PHE   A CA   1 
ATOM   2329 C  C    . PHE   A 1 155 ? 8.28612   6.22199   20.58000 1.000 39.41547  ? 1098 PHE   A C    1 
ATOM   2330 O  O    . PHE   A 1 155 ? 7.76618   7.34347   20.56655 1.000 40.06160  ? 1098 PHE   A O    1 
ATOM   2331 C  CB   . PHE   A 1 155 ? 10.44045  6.90294   21.70972 1.000 36.17204  ? 1098 PHE   A CB   1 
ATOM   2332 C  CG   . PHE   A 1 155 ? 10.27400  6.33401   23.09898 1.000 36.87532  ? 1098 PHE   A CG   1 
ATOM   2333 C  CD1  . PHE   A 1 155 ? 10.47354  4.98911   23.36592 1.000 41.37946  ? 1098 PHE   A CD1  1 
ATOM   2334 C  CD2  . PHE   A 1 155 ? 9.98972   7.17770   24.16121 1.000 38.73888  ? 1098 PHE   A CD2  1 
ATOM   2335 C  CE1  . PHE   A 1 155 ? 10.34304  4.49278   24.64946 1.000 40.81123  ? 1098 PHE   A CE1  1 
ATOM   2336 C  CE2  . PHE   A 1 155 ? 9.87490   6.67837   25.44425 1.000 36.13083  ? 1098 PHE   A CE2  1 
ATOM   2337 C  CZ   . PHE   A 1 155 ? 10.04634  5.33472   25.68333 1.000 35.13604  ? 1098 PHE   A CZ   1 
ATOM   2338 H  H    . PHE   A 1 155 ? 10.14085  7.44858   19.23120 1.000 44.40200  ? 1098 PHE   A H    1 
ATOM   2339 H  HA   . PHE   A 1 155 ? 10.03944  5.16421   20.75080 1.000 35.63126  ? 1098 PHE   A HA   1 
ATOM   2340 H  HB2  . PHE   A 1 155 ? 11.39225  6.96352   21.53281 1.000 43.42173  ? 1098 PHE   A HB2  1 
ATOM   2341 H  HB3  . PHE   A 1 155 ? 10.04592  7.78908   21.70959 1.000 43.42173  ? 1098 PHE   A HB3  1 
ATOM   2342 H  HD1  . PHE   A 1 155 ? 10.69839  4.41232   22.67191 1.000 49.67062  ? 1098 PHE   A HD1  1 
ATOM   2343 H  HD2  . PHE   A 1 155 ? 9.87526   8.08799   24.00894 1.000 46.50194  ? 1098 PHE   A HD2  1 
ATOM   2344 H  HE1  . PHE   A 1 155 ? 10.45747  3.58381   24.80939 1.000 48.98875  ? 1098 PHE   A HE1  1 
ATOM   2345 H  HE2  . PHE   A 1 155 ? 9.68088   7.25309   26.14920 1.000 43.37228  ? 1098 PHE   A HE2  1 
ATOM   2346 H  HZ   . PHE   A 1 155 ? 9.96046   5.00027   26.54685 1.000 42.17853  ? 1098 PHE   A HZ   1 
ATOM   2347 N  N    . CYS   A 1 156 ? 7.58426   5.08965   20.55222 1.000 35.42653  ? 1099 CYS   A N    1 
ATOM   2348 C  CA   . CYS   A 1 156 ? 6.17007   5.06698   20.21068 1.000 38.81791  ? 1099 CYS   A CA   1 
ATOM   2349 C  C    . CYS   A 1 156 ? 5.27118   4.53244   21.31815 1.000 36.44626  ? 1099 CYS   A C    1 
ATOM   2350 O  O    . CYS   A 1 156 ? 5.67039   3.73044   22.15189 1.000 36.22362  ? 1099 CYS   A O    1 
ATOM   2351 C  CB   . CYS   A 1 156 ? 5.90112   4.20060   18.97773 1.000 43.27871  ? 1099 CYS   A CB   1 
ATOM   2352 S  SG   . CYS   A 1 156 ? 7.03948   4.40477   17.64080 1.000 40.35868  ? 1099 CYS   A SG   1 
ATOM   2353 H  H    . CYS   A 1 156 ? 7.91261   4.31496   20.73012 1.000 42.52711  ? 1099 CYS   A H    1 
ATOM   2354 H  HA   . CYS   A 1 156 ? 5.92994   5.99424   20.05762 1.000 46.59676  ? 1099 CYS   A HA   1 
ATOM   2355 H  HB2  . CYS   A 1 156 ? 5.93524   3.26914   19.24629 1.000 51.94973  ? 1099 CYS   A HB2  1 
ATOM   2356 H  HB3  . CYS   A 1 156 ? 5.01770   4.41642   18.64025 1.000 51.94973  ? 1099 CYS   A HB3  1 
ATOM   2357 H  HG   . CYS   A 1 156 ? 6.68800   3.71978   16.72033 1.000 48.44569  ? 1099 CYS   A HG   1 
ATOM   2358 N  N    . ARG   A 1 157 ? 4.02305   4.95971   21.27809 1.000 37.71260  ? 1100 ARG   A N    1 
ATOM   2359 C  CA   . ARG   A 1 157 ? 3.00376   4.47446   22.17888 1.000 27.20590  ? 1100 ARG   A CA   1 
ATOM   2360 C  C    . ARG   A 1 157 ? 2.29302   3.31291   21.47731 1.000 39.16728  ? 1100 ARG   A C    1 
ATOM   2361 O  O    . ARG   A 1 157 ? 1.76902   3.49644   20.37320 1.000 34.66252  ? 1100 ARG   A O    1 
ATOM   2362 C  CB   . ARG   A 1 157 ? 2.06492   5.62308   22.53757 1.000 34.20344  ? 1100 ARG   A CB   1 
ATOM   2363 C  CG   . ARG   A 1 157 ? 1.10223   5.32711   23.70549 1.000 39.49950  ? 1100 ARG   A CG   1 
ATOM   2364 C  CD   . ARG   A 1 157 ? 0.28149   6.55136   24.13027 1.000 38.79140  ? 1100 ARG   A CD   1 
ATOM   2365 N  NE   . ARG   A 1 157 ? 1.08437   7.65988   24.64440 1.000 38.18673  ? 1100 ARG   A NE   1 
ATOM   2366 C  CZ   . ARG   A 1 157 ? 1.34665   7.85692   25.92862 1.000 44.12892  ? 1100 ARG   A CZ   1 
ATOM   2367 N  NH1  . ARG   A 1 157 ? 0.89263   7.02586   26.86245 1.000 41.38272  ? 1100 ARG   A NH1  1 
ATOM   2368 N  NH2  . ARG   A 1 157 ? 2.07635   8.91347   26.28793 1.000 47.09710  ? 1100 ARG   A NH2  1 
ATOM   2369 H  H    . ARG   A 1 157 ? 3.73570   5.54807   20.72053 1.000 45.27039  ? 1100 ARG   A H    1 
ATOM   2370 H  HA   . ARG   A 1 157 ? 3.37009   4.13643   23.01101 1.000 32.66236  ? 1100 ARG   A HA   1 
ATOM   2371 H  HB2  . ARG   A 1 157 ? 2.60042   6.39212   22.78802 1.000 41.05941  ? 1100 ARG   A HB2  1 
ATOM   2372 H  HB3  . ARG   A 1 157 ? 1.52479   5.83397   21.75996 1.000 41.05941  ? 1100 ARG   A HB3  1 
ATOM   2373 H  HG2  . ARG   A 1 157 ? 0.48262   4.63145   23.43523 1.000 47.41468  ? 1100 ARG   A HG2  1 
ATOM   2374 H  HG3  . ARG   A 1 157 ? 1.61775   5.03253   24.47254 1.000 47.41468  ? 1100 ARG   A HG3  1 
ATOM   2375 H  HD2  . ARG   A 1 157 ? -0.21146  6.87744   23.36113 1.000 46.56496  ? 1100 ARG   A HD2  1 
ATOM   2376 H  HD3  . ARG   A 1 157 ? -0.33456  6.28506   24.83060 1.000 46.56496  ? 1100 ARG   A HD3  1 
ATOM   2377 H  HE   . ARG   A 1 157 ? 1.40713   8.21997   24.07720 1.000 45.83936  ? 1100 ARG   A HE   1 
ATOM   2378 H  HH11 . ARG   A 1 157 ? 0.41859   6.34435   26.63789 1.000 49.67454  ? 1100 ARG   A HH11 1 
ATOM   2379 H  HH12 . ARG   A 1 157 ? 1.07308   7.16999   27.69086 1.000 49.67454  ? 1100 ARG   A HH12 1 
ATOM   2380 H  HH21 . ARG   A 1 157 ? 2.37029   9.45664   25.68947 1.000 56.53179  ? 1100 ARG   A HH21 1 
ATOM   2381 H  HH22 . ARG   A 1 157 ? 2.25305   9.05175   27.11814 1.000 56.53179  ? 1100 ARG   A HH22 1 
ATOM   2382 N  N    . VAL   A 1 158 ? 2.30316   2.11894   22.09537 1.000 32.44198  ? 1101 VAL   A N    1 
ATOM   2383 C  CA   . VAL   A 1 158 ? 1.83454   0.88180   21.45465 1.000 32.00478  ? 1101 VAL   A CA   1 
ATOM   2384 C  C    . VAL   A 1 158 ? 0.78055   0.17553   22.31170 1.000 37.71293  ? 1101 VAL   A C    1 
ATOM   2385 O  O    . VAL   A 1 158 ? 1.02717   -0.14566  23.47599 1.000 36.38746  ? 1101 VAL   A O    1 
ATOM   2386 C  CB   . VAL   A 1 158 ? 3.00444   -0.08751  21.19192 1.000 35.31365  ? 1101 VAL   A CB   1 
ATOM   2387 C  CG1  . VAL   A 1 158 ? 2.51433   -1.38049  20.51221 1.000 30.87174  ? 1101 VAL   A CG1  1 
ATOM   2388 C  CG2  . VAL   A 1 158 ? 4.11928   0.62343   20.39660 1.000 33.69256  ? 1101 VAL   A CG2  1 
ATOM   2389 H  H    . VAL   A 1 158 ? 2.58239   2.00131   22.90022 1.000 38.94565  ? 1101 VAL   A H    1 
ATOM   2390 H  HA   . VAL   A 1 158 ? 1.40345   1.13402   20.62311 1.000 38.42101  ? 1101 VAL   A HA   1 
ATOM   2391 H  HB   . VAL   A 1 158 ? 3.39186   -0.36180  22.03784 1.000 42.39166  ? 1101 VAL   A HB   1 
ATOM   2392 H  HG11 . VAL   A 1 158 ? 3.28289   -1.88913  20.20973 1.000 37.06137  ? 1101 VAL   A HG11 1 
ATOM   2393 H  HG12 . VAL   A 1 158 ? 2.00487   -1.90064  21.15314 1.000 37.06137  ? 1101 VAL   A HG12 1 
ATOM   2394 H  HG13 . VAL   A 1 158 ? 1.95386   -1.14674  19.75581 1.000 37.06137  ? 1101 VAL   A HG13 1 
ATOM   2395 H  HG21 . VAL   A 1 158 ? 4.84137   -0.00385  20.23538 1.000 40.44635  ? 1101 VAL   A HG21 1 
ATOM   2396 H  HG22 . VAL   A 1 158 ? 3.75615   0.93388   19.55241 1.000 40.44635  ? 1101 VAL   A HG22 1 
ATOM   2397 H  HG23 . VAL   A 1 158 ? 4.44483   1.37679   20.91369 1.000 40.44635  ? 1101 VAL   A HG23 1 
ATOM   2398 N  N    . THR   A 1 159 ? -0.34045  -0.16229  21.70563 1.000 34.73765  ? 1102 THR   A N    1 
ATOM   2399 C  CA   . THR   A 1 159 ? -1.39256  -0.94246  22.36607 1.000 31.79328  ? 1102 THR   A CA   1 
ATOM   2400 C  C    . THR   A 1 159 ? -1.18573  -2.44288  22.09291 1.000 31.39827  ? 1102 THR   A C    1 
ATOM   2401 O  O    . THR   A 1 159 ? -1.30077  -2.89068  20.95457 1.000 37.27388  ? 1102 THR   A O    1 
ATOM   2402 C  CB   . THR   A 1 159 ? -2.74155  -0.47118  21.84782 1.000 33.37128  ? 1102 THR   A CB   1 
ATOM   2403 O  OG1  . THR   A 1 159 ? -3.02710  0.81870   22.38525 1.000 37.02244  ? 1102 THR   A OG1  1 
ATOM   2404 C  CG2  . THR   A 1 159 ? -3.82642  -1.38898  22.24471 1.000 35.89458  ? 1102 THR   A CG2  1 
ATOM   2405 H  H    . THR   A 1 159 ? -0.52842  0.04877   20.89340 1.000 41.70045  ? 1102 THR   A H    1 
ATOM   2406 H  HA   . THR   A 1 159 ? -1.34147  -0.82093  23.32707 1.000 38.16722  ? 1102 THR   A HA   1 
ATOM   2407 H  HB   . THR   A 1 159 ? -2.70834  -0.44044  20.87888 1.000 40.06081  ? 1102 THR   A HB   1 
ATOM   2408 H  HG1  . THR   A 1 159 ? -2.44573  1.37011   22.13315 1.000 44.44221  ? 1102 THR   A HG1  1 
ATOM   2409 H  HG21 . THR   A 1 159 ? -4.68374  -0.94152  22.16935 1.000 43.08878  ? 1102 THR   A HG21 1 
ATOM   2410 H  HG22 . THR   A 1 159 ? -3.82733  -2.17000  21.66946 1.000 43.08878  ? 1102 THR   A HG22 1 
ATOM   2411 H  HG23 . THR   A 1 159 ? -3.70004  -1.67457  23.16306 1.000 43.08878  ? 1102 THR   A HG23 1 
ATOM   2412 N  N    . LEU   A 1 160 ? -0.85252  -3.21298  23.13030 1.000 33.81664  ? 1103 LEU   A N    1 
ATOM   2413 C  CA   . LEU   A 1 160 ? -0.57279  -4.64038  22.94937 1.000 34.59295  ? 1103 LEU   A CA   1 
ATOM   2414 C  C    . LEU   A 1 160 ? -1.79003  -5.52393  23.15637 1.000 29.62319  ? 1103 LEU   A C    1 
ATOM   2415 O  O    . LEU   A 1 160 ? -1.84776  -6.61896  22.59948 1.000 42.37745  ? 1103 LEU   A O    1 
ATOM   2416 C  CB   . LEU   A 1 160 ? 0.48820   -5.10753  23.92215 1.000 32.87504  ? 1103 LEU   A CB   1 
ATOM   2417 C  CG   . LEU   A 1 160 ? 1.85456   -4.48717  23.71047 1.000 40.94207  ? 1103 LEU   A CG   1 
ATOM   2418 C  CD1  . LEU   A 1 160 ? 2.76177   -5.03494  24.74873 1.000 36.99366  ? 1103 LEU   A CD1  1 
ATOM   2419 C  CD2  . LEU   A 1 160 ? 2.34268   -4.78883  22.31602 1.000 37.55363  ? 1103 LEU   A CD2  1 
ATOM   2420 H  H    . LEU   A 1 160 ? -0.78206  -2.93640  23.94156 1.000 40.59525  ? 1103 LEU   A H    1 
ATOM   2421 H  HA   . LEU   A 1 160 ? -0.24761  -4.75338  22.04251 1.000 41.52681  ? 1103 LEU   A HA   1 
ATOM   2422 H  HB2  . LEU   A 1 160 ? 0.20105   -4.88464  24.82146 1.000 39.46533  ? 1103 LEU   A HB2  1 
ATOM   2423 H  HB3  . LEU   A 1 160 ? 0.58553   -6.06856  23.83357 1.000 39.46533  ? 1103 LEU   A HB3  1 
ATOM   2424 H  HG   . LEU   A 1 160 ? 1.83058   -3.52098  23.79289 1.000 49.14576  ? 1103 LEU   A HG   1 
ATOM   2425 H  HD11 . LEU   A 1 160 ? 3.64448   -4.65019  24.63169 1.000 44.40767  ? 1103 LEU   A HD11 1 
ATOM   2426 H  HD12 . LEU   A 1 160 ? 2.41432   -4.80526  25.62476 1.000 44.40767  ? 1103 LEU   A HD12 1 
ATOM   2427 H  HD13 . LEU   A 1 160 ? 2.80585   -5.99917  24.65276 1.000 44.40767  ? 1103 LEU   A HD13 1 
ATOM   2428 H  HD21 . LEU   A 1 160 ? 3.29057   -4.58977  22.26326 1.000 45.07964  ? 1103 LEU   A HD21 1 
ATOM   2429 H  HD22 . LEU   A 1 160 ? 2.19063   -5.72747  22.12435 1.000 45.07964  ? 1103 LEU   A HD22 1 
ATOM   2430 H  HD23 . LEU   A 1 160 ? 1.85351   -4.23877  21.68430 1.000 45.07964  ? 1103 LEU   A HD23 1 
ATOM   2431 N  N    . GLY   A 1 161 ? -2.75380  -5.07375  23.95037 1.000 37.14327  ? 1104 GLY   A N    1 
ATOM   2432 C  CA   . GLY   A 1 161 ? -3.92668  -5.84685  24.28590 1.000 34.68044  ? 1104 GLY   A CA   1 
ATOM   2433 C  C    . GLY   A 1 161 ? -3.53011  -7.18566  24.86596 1.000 38.83954  ? 1104 GLY   A C    1 
ATOM   2434 O  O    . GLY   A 1 161 ? -2.52021  -7.32160  25.56645 1.000 38.23098  ? 1104 GLY   A O    1 
ATOM   2435 H  H    . GLY   A 1 161 ? -2.74736  -4.29621  24.31778 1.000 44.58719  ? 1104 GLY   A H    1 
ATOM   2436 H  HA2  . GLY   A 1 161 ? -4.46020  -5.36778  24.93915 1.000 41.63181  ? 1104 GLY   A HA2  1 
ATOM   2437 H  HA3  . GLY   A 1 161 ? -4.46078  -5.99582  23.49001 1.000 41.63181  ? 1104 GLY   A HA3  1 
ATOM   2438 N  N    . LYS   A 1 162 ? -4.33830  -8.19340  24.57691 1.000 40.55860  ? 1105 LYS   A N    1 
ATOM   2439 C  CA   . LYS   A 1 162 ? -3.98104  -9.55748  24.94063 1.000 35.70092  ? 1105 LYS   A CA   1 
ATOM   2440 C  C    . LYS   A 1 162 ? -2.86603  -10.00749 24.01634 1.000 32.48201  ? 1105 LYS   A C    1 
ATOM   2441 O  O    . LYS   A 1 162 ? -3.08634  -10.22486 22.81811 1.000 38.04395  ? 1105 LYS   A O    1 
ATOM   2442 C  CB   . LYS   A 1 162 ? -5.18398  -10.49773 24.85909 1.000 38.77296  ? 1105 LYS   A CB   1 
ATOM   2443 C  CG   . LYS   A 1 162 ? -4.77536  -11.92932 25.26345 1.000 44.89104  ? 1105 LYS   A CG   1 
ATOM   2444 C  CD   . LYS   A 1 162 ? -5.89987  -12.92333 25.32795 1.000 55.05828  ? 1105 LYS   A CD   1 
ATOM   2445 C  CE   . LYS   A 1 162 ? -5.38456  -14.36529 25.56594 1.000 64.11315  ? 1105 LYS   A CE   1 
ATOM   2446 N  NZ   . LYS   A 1 162 ? -4.37424  -14.56332 26.69988 1.000 64.64951  ? 1105 LYS   A NZ   1 
ATOM   2447 H  H    . LYS   A 1 162 ? -5.09391  -8.11562  24.17367 1.000 48.68560  ? 1105 LYS   A H    1 
ATOM   2448 H  HA   . LYS   A 1 162 ? -3.67736  -9.57822  25.86164 1.000 42.85638  ? 1105 LYS   A HA   1 
ATOM   2449 H  HB2  . LYS   A 1 162 ? -5.87777  -10.19061 25.46343 1.000 46.54282  ? 1105 LYS   A HB2  1 
ATOM   2450 H  HB3  . LYS   A 1 162 ? -5.52061  -10.51627 23.94956 1.000 46.54282  ? 1105 LYS   A HB3  1 
ATOM   2451 H  HG2  . LYS   A 1 162 ? -4.13442  -12.26016 24.61487 1.000 53.88453  ? 1105 LYS   A HG2  1 
ATOM   2452 H  HG3  . LYS   A 1 162 ? -4.36920  -11.89535 26.14367 1.000 53.88453  ? 1105 LYS   A HG3  1 
ATOM   2453 H  HD2  . LYS   A 1 162 ? -6.49240  -12.68869 26.05922 1.000 66.08521  ? 1105 LYS   A HD2  1 
ATOM   2454 H  HD3  . LYS   A 1 162 ? -6.38677  -12.91008 24.48911 1.000 66.08521  ? 1105 LYS   A HD3  1 
ATOM   2455 H  HE2  . LYS   A 1 162 ? -6.14874  -14.92741 25.76828 1.000 76.95105  ? 1105 LYS   A HE2  1 
ATOM   2456 H  HE3  . LYS   A 1 162 ? -4.95586  -14.66909 24.75057 1.000 76.95105  ? 1105 LYS   A HE3  1 
ATOM   2457 H  HZ1  . LYS   A 1 162 ? -4.14549  -15.42150 26.75735 1.000 77.59469  ? 1105 LYS   A HZ1  1 
ATOM   2458 H  HZ2  . LYS   A 1 162 ? -3.64360  -14.07943 26.54456 1.000 77.59469  ? 1105 LYS   A HZ2  1 
ATOM   2459 H  HZ3  . LYS   A 1 162 ? -4.73123  -14.30711 27.47384 1.000 77.59469  ? 1105 LYS   A HZ3  1 
ATOM   2460 N  N    . SER   A 1 163 ? -1.65749  -10.10174 24.54459 1.000 39.82148  ? 1106 SER   A N    1 
ATOM   2461 C  CA   . SER   A 1 163 ? -0.50165  -10.43635 23.73241 1.000 42.10702  ? 1106 SER   A CA   1 
ATOM   2462 C  C    . SER   A 1 163 ? -0.26374  -11.93585 23.78808 1.000 39.16182  ? 1106 SER   A C    1 
ATOM   2463 O  O    . SER   A 1 163 ? -0.36782  -12.55727 24.84292 1.000 45.49432  ? 1106 SER   A O    1 
ATOM   2464 C  CB   . SER   A 1 163 ? 0.74824   -9.69181  24.21680 1.000 28.51606  ? 1106 SER   A CB   1 
ATOM   2465 O  OG   . SER   A 1 163 ? 1.69135   -9.57336  23.18041 1.000 42.26203  ? 1106 SER   A OG   1 
ATOM   2466 H  H    . SER   A 1 163 ? -1.47984  -9.97561  25.37653 1.000 47.80105  ? 1106 SER   A H    1 
ATOM   2467 H  HA   . SER   A 1 163 ? -0.66277  -10.17319 22.81279 1.000 50.54371  ? 1106 SER   A HA   1 
ATOM   2468 H  HB2  . SER   A 1 163 ? 0.49227   -8.80467  24.51406 1.000 34.23454  ? 1106 SER   A HB2  1 
ATOM   2469 H  HB3  . SER   A 1 163 ? 1.14573   -10.18583 24.95086 1.000 34.23454  ? 1106 SER   A HB3  1 
ATOM   2470 H  HG   . SER   A 1 163 ? 2.34887   -9.12003  23.44073 1.000 50.72971  ? 1106 SER   A HG   1 
ATOM   2471 N  N    . PHE   A 1 164 ? 0.02220   -12.51421 22.63595 1.000 43.28924  ? 1107 PHE   A N    1 
ATOM   2472 C  CA   . PHE   A 1 164 ? 0.33066   -13.92963 22.54625 1.000 46.02427  ? 1107 PHE   A CA   1 
ATOM   2473 C  C    . PHE   A 1 164 ? 1.79467   -14.12739 22.89320 1.000 42.42867  ? 1107 PHE   A C    1 
ATOM   2474 O  O    . PHE   A 1 164 ? 2.67059   -13.55042 22.24574 1.000 38.22797  ? 1107 PHE   A O    1 
ATOM   2475 C  CB   . PHE   A 1 164 ? 0.04164   -14.44670 21.14644 1.000 50.87929  ? 1107 PHE   A CB   1 
ATOM   2476 C  CG   . PHE   A 1 164 ? 0.22747   -15.90827 21.01431 1.000 56.10321  ? 1107 PHE   A CG   1 
ATOM   2477 C  CD1  . PHE   A 1 164 ? 1.46705   -16.43660 20.71598 1.000 50.37834  ? 1107 PHE   A CD1  1 
ATOM   2478 C  CD2  . PHE   A 1 164 ? -0.83612  -16.76298 21.22283 1.000 58.11431  ? 1107 PHE   A CD2  1 
ATOM   2479 C  CE1  . PHE   A 1 164 ? 1.63812   -17.78353 20.61079 1.000 62.45758  ? 1107 PHE   A CE1  1 
ATOM   2480 C  CE2  . PHE   A 1 164 ? -0.66953  -18.11459 21.12093 1.000 55.73542  ? 1107 PHE   A CE2  1 
ATOM   2481 C  CZ   . PHE   A 1 164 ? 0.56154   -18.62832 20.81350 1.000 58.02177  ? 1107 PHE   A CZ   1 
ATOM   2482 H  H    . PHE   A 1 164 ? 0.04473   -12.10363 21.88063 1.000 51.96236  ? 1107 PHE   A H    1 
ATOM   2483 H  HA   . PHE   A 1 164 ? -0.21794  -14.42885 23.17131 1.000 55.24440  ? 1107 PHE   A HA   1 
ATOM   2484 H  HB2  . PHE   A 1 164 ? -0.87889  -14.24136 20.91981 1.000 61.07042  ? 1107 PHE   A HB2  1 
ATOM   2485 H  HB3  . PHE   A 1 164 ? 0.64220   -14.01191 20.52099 1.000 61.07042  ? 1107 PHE   A HB3  1 
ATOM   2486 H  HD1  . PHE   A 1 164 ? 2.19147   -15.86813 20.58573 1.000 60.46929  ? 1107 PHE   A HD1  1 
ATOM   2487 H  HD2  . PHE   A 1 164 ? -1.67255  -16.41577 21.43433 1.000 69.75245  ? 1107 PHE   A HD2  1 
ATOM   2488 H  HE1  . PHE   A 1 164 ? 2.47444   -18.13367 20.40373 1.000 74.96438  ? 1107 PHE   A HE1  1 
ATOM   2489 H  HE2  . PHE   A 1 164 ? -1.39090  -18.68482 21.26009 1.000 66.89778  ? 1107 PHE   A HE2  1 
ATOM   2490 H  HZ   . PHE   A 1 164 ? 0.67455   -19.54855 20.74065 1.000 69.64140  ? 1107 PHE   A HZ   1 
ATOM   2491 N  N    . LEU   A 1 165 ? 2.05733   -14.92213 23.91464 1.000 42.43227  ? 1108 LEU   A N    1 
ATOM   2492 C  CA   . LEU   A 1 165 ? 3.42056   -15.10842 24.38848 1.000 43.92206  ? 1108 LEU   A CA   1 
ATOM   2493 C  C    . LEU   A 1 165 ? 4.13481   -16.18640 23.57825 1.000 43.02469  ? 1108 LEU   A C    1 
ATOM   2494 O  O    . LEU   A 1 165 ? 3.67389   -17.32295 23.45686 1.000 44.50011  ? 1108 LEU   A O    1 
ATOM   2495 C  CB   . LEU   A 1 165 ? 3.39413   -15.45911 25.86890 1.000 43.47868  ? 1108 LEU   A CB   1 
ATOM   2496 C  CG   . LEU   A 1 165 ? 4.45442   -14.86274 26.77447 1.000 61.82678  ? 1108 LEU   A CG   1 
ATOM   2497 C  CD1  . LEU   A 1 165 ? 4.51486   -13.36530 26.65229 1.000 67.09388  ? 1108 LEU   A CD1  1 
ATOM   2498 C  CD2  . LEU   A 1 165 ? 4.11136   -15.25223 28.17032 1.000 60.65478  ? 1108 LEU   A CD2  1 
ATOM   2499 H  H    . LEU   A 1 165 ? 1.46527   -15.36636 24.35250 1.000 50.93400  ? 1108 LEU   A H    1 
ATOM   2500 H  HA   . LEU   A 1 165 ? 3.92646   -14.28896 24.27251 1.000 52.72174  ? 1108 LEU   A HA   1 
ATOM   2501 H  HB2  . LEU   A 1 165 ? 2.53705   -15.17306 26.22174 1.000 52.18969  ? 1108 LEU   A HB2  1 
ATOM   2502 H  HB3  . LEU   A 1 165 ? 3.47834   -16.42264 25.94255 1.000 52.18969  ? 1108 LEU   A HB3  1 
ATOM   2503 H  HG   . LEU   A 1 165 ? 5.33227   -15.19285 26.52686 1.000 74.20741  ? 1108 LEU   A HG   1 
ATOM   2504 H  HD11 . LEU   A 1 165 ? 4.88717   -12.99662 27.46860 1.000 80.52794  ? 1108 LEU   A HD11 1 
ATOM   2505 H  HD12 . LEU   A 1 165 ? 5.07772   -13.13251 25.89738 1.000 80.52794  ? 1108 LEU   A HD12 1 
ATOM   2506 H  HD13 . LEU   A 1 165 ? 3.61777   -13.02328 26.51392 1.000 80.52794  ? 1108 LEU   A HD13 1 
ATOM   2507 H  HD21 . LEU   A 1 165 ? 4.74774   -14.84354 28.77769 1.000 72.80101  ? 1108 LEU   A HD21 1 
ATOM   2508 H  HD22 . LEU   A 1 165 ? 3.21474   -14.94274 28.37325 1.000 72.80101  ? 1108 LEU   A HD22 1 
ATOM   2509 H  HD23 . LEU   A 1 165 ? 4.15337   -16.21820 28.24803 1.000 72.80101  ? 1108 LEU   A HD23 1 
ATOM   2510 N  N    . GLN   A 1 166 ? 5.28462   -15.82708 23.04247 1.000 48.36381  ? 1109 GLN   A N    1 
ATOM   2511 C  CA   . GLN   A 1 166 ? 6.05918   -16.69696 22.17353 1.000 47.96188  ? 1109 GLN   A CA   1 
ATOM   2512 C  C    . GLN   A 1 166 ? 7.47175   -16.80302 22.73537 1.000 55.93913  ? 1109 GLN   A C    1 
ATOM   2513 O  O    . GLN   A 1 166 ? 8.18781   -15.80252 22.83328 1.000 54.64873  ? 1109 GLN   A O    1 
ATOM   2514 C  CB   . GLN   A 1 166 ? 6.02603   -16.12164 20.75669 1.000 54.01986  ? 1109 GLN   A CB   1 
ATOM   2515 C  CG   . GLN   A 1 166 ? 6.75030   -16.87972 19.72624 1.000 54.74844  ? 1109 GLN   A CG   1 
ATOM   2516 C  CD   . GLN   A 1 166 ? 6.03269   -18.13404 19.36865 1.000 51.34639  ? 1109 GLN   A CD   1 
ATOM   2517 O  OE1  . GLN   A 1 166 ? 6.43822   -19.20196 19.78528 1.000 54.90645  ? 1109 GLN   A OE1  1 
ATOM   2518 N  NE2  . GLN   A 1 166 ? 4.96192   -18.01893 18.59358 1.000 54.13468  ? 1109 GLN   A NE2  1 
ATOM   2519 H  H    A GLN   A 1 166 ? 5.65098   -15.05956 23.17009 0.610 58.05185  ? 1109 GLN   A H    1 
ATOM   2520 H  H    B GLN   A 1 166 ? 5.65098   -15.05956 23.17009 0.390 58.05185  ? 1109 GLN   A H    1 
ATOM   2521 H  HA   . GLN   A 1 166 ? 5.70819   -17.60092 22.14968 1.000 57.56953  ? 1109 GLN   A HA   1 
ATOM   2522 H  HB2  . GLN   A 1 166 ? 5.09962   -16.07003 20.47385 1.000 64.83911  ? 1109 GLN   A HB2  1 
ATOM   2523 H  HB3  . GLN   A 1 166 ? 6.41491   -15.23339 20.78281 1.000 64.83911  ? 1109 GLN   A HB3  1 
ATOM   2524 H  HG2  . GLN   A 1 166 ? 6.83325   -16.33665 18.92681 1.000 65.71340  ? 1109 GLN   A HG2  1 
ATOM   2525 H  HG3  . GLN   A 1 166 ? 7.63006   -17.11554 20.05987 1.000 65.71340  ? 1109 GLN   A HG3  1 
ATOM   2526 H  HE21 . GLN   A 1 166 ? 4.71021   -17.24330 18.32039 1.000 64.97690  ? 1109 GLN   A HE21 1 
ATOM   2527 H  HE22 . GLN   A 1 166 ? 4.51961   -18.71996 18.36441 1.000 64.97690  ? 1109 GLN   A HE22 1 
ATOM   2528 N  N    . PHE   A 1 167 ? 7.86845   -18.01254 23.11971 1.000 50.48531  ? 1110 PHE   A N    1 
ATOM   2529 C  CA   . PHE   A 1 167 ? 9.17631   -18.25421 23.71787 1.000 55.19130  ? 1110 PHE   A CA   1 
ATOM   2530 C  C    . PHE   A 1 167 ? 10.22649  -18.50548 22.64145 1.000 62.66907  ? 1110 PHE   A C    1 
ATOM   2531 O  O    . PHE   A 1 167 ? 9.99421   -19.28302 21.70827 1.000 62.51825  ? 1110 PHE   A O    1 
ATOM   2532 C  CB   . PHE   A 1 167 ? 9.07111   -19.43549 24.68357 1.000 55.13602  ? 1110 PHE   A CB   1 
ATOM   2533 C  CG   . PHE   A 1 167 ? 8.32256   -19.09643 25.92142 1.000 57.27261  ? 1110 PHE   A CG   1 
ATOM   2534 C  CD1  . PHE   A 1 167 ? 6.95964   -18.90013 25.87427 1.000 56.99582  ? 1110 PHE   A CD1  1 
ATOM   2535 C  CD2  . PHE   A 1 167 ? 8.98711   -18.91239 27.12018 1.000 58.18537  ? 1110 PHE   A CD2  1 
ATOM   2536 C  CE1  . PHE   A 1 167 ? 6.26777   -18.54398 27.00502 1.000 59.98926  ? 1110 PHE   A CE1  1 
ATOM   2537 C  CE2  . PHE   A 1 167 ? 8.30124   -18.55403 28.26208 1.000 57.20470  ? 1110 PHE   A CE2  1 
ATOM   2538 C  CZ   . PHE   A 1 167 ? 6.93806   -18.37180 28.20803 1.000 58.85592  ? 1110 PHE   A CZ   1 
ATOM   2539 H  H    . PHE   A 1 167 ? 7.38878   -18.72220 23.04289 1.000 60.59765  ? 1110 PHE   A H    1 
ATOM   2540 H  HA   . PHE   A 1 167 ? 9.47144   -17.47127 24.20859 1.000 66.24483  ? 1110 PHE   A HA   1 
ATOM   2541 H  HB2  . PHE   A 1 167 ? 8.60814   -20.16466 24.24213 1.000 66.17851  ? 1110 PHE   A HB2  1 
ATOM   2542 H  HB3  . PHE   A 1 167 ? 9.96393   -19.71569 24.93903 1.000 66.17851  ? 1110 PHE   A HB3  1 
ATOM   2543 H  HD1  . PHE   A 1 167 ? 6.50507   -19.00973 25.07037 1.000 68.41026  ? 1110 PHE   A HD1  1 
ATOM   2544 H  HD2  . PHE   A 1 167 ? 9.90867   -19.03182 27.15695 1.000 69.83772  ? 1110 PHE   A HD2  1 
ATOM   2545 H  HE1  . PHE   A 1 167 ? 5.34725   -18.41770 26.96489 1.000 72.00238  ? 1110 PHE   A HE1  1 
ATOM   2546 H  HE2  . PHE   A 1 167 ? 8.75734   -18.43621 29.06395 1.000 68.66092  ? 1110 PHE   A HE2  1 
ATOM   2547 H  HZ   . PHE   A 1 167 ? 6.46803   -18.13426 28.97454 1.000 70.64238  ? 1110 PHE   A HZ   1 
ATOM   2548 N  N    . SER   A 1 168 ? 11.37940  -17.83902 22.77687 1.000 66.41385  ? 1111 SER   A N    1 
ATOM   2549 C  CA   . SER   A 1 168 ? 12.39232  -17.77007 21.71620 1.000 71.66987  ? 1111 SER   A CA   1 
ATOM   2550 C  C    . SER   A 1 168 ? 13.46035  -16.72494 22.02861 1.000 75.86878  ? 1111 SER   A C    1 
ATOM   2551 O  O    . SER   A 1 168 ? 14.55181  -16.74255 21.45042 1.000 90.30298  ? 1111 SER   A O    1 
ATOM   2552 C  CB   . SER   A 1 168 ? 11.74833  -17.42564 20.35837 1.000 79.97908  ? 1111 SER   A CB   1 
ATOM   2553 O  OG   . SER   A 1 168 ? 10.97068  -16.22657 20.45206 1.000 71.30930  ? 1111 SER   A OG   1 
ATOM   2554 H  H    . SER   A 1 168 ? 11.60317  -17.40986 23.48776 1.000 79.71190  ? 1111 SER   A H    1 
ATOM   2555 H  HA   . SER   A 1 168 ? 12.81442  -18.64106 21.65216 1.000 86.01912  ? 1111 SER   A HA   1 
ATOM   2556 H  HB2  . SER   A 1 168 ? 12.44917  -17.29673 19.70026 1.000 95.99018  ? 1111 SER   A HB2  1 
ATOM   2557 H  HB3  . SER   A 1 168 ? 11.17035  -18.15646 20.08869 1.000 95.99018  ? 1111 SER   A HB3  1 
ATOM   2558 H  HG   . SER   A 1 168 ? 10.61474  -16.05630 19.71050 1.000 85.58644  ? 1111 SER   A HG   1 
ATOM   2559 N  N    . MET   B 2 1   ? -0.14192  -7.92548  5.20295  1.000 69.86240  ? 1115 MET   E N    1 
ATOM   2560 C  CA   . MET   B 2 1   ? -0.45615  -7.93852  6.63436  1.000 93.02460  ? 1115 MET   E CA   1 
ATOM   2561 C  C    . MET   B 2 1   ? -1.12175  -9.21865  7.10477  1.000 80.60076  ? 1115 MET   E C    1 
ATOM   2562 O  O    . MET   B 2 1   ? -2.16097  -9.61386  6.57771  1.000 83.89011  ? 1115 MET   E O    1 
ATOM   2563 C  CB   . MET   B 2 1   ? -1.38888  -6.78990  7.00602  1.000 105.51266 ? 1115 MET   E CB   1 
ATOM   2564 C  CG   . MET   B 2 1   ? -0.69036  -5.54642  7.44146  1.000 83.35254  ? 1115 MET   E CG   1 
ATOM   2565 S  SD   . MET   B 2 1   ? -0.01508  -5.61348  9.10652  1.000 84.32571  ? 1115 MET   E SD   1 
ATOM   2566 C  CE   . MET   B 2 1   ? -0.00118  -3.86016  9.48215  1.000 51.42700  ? 1115 MET   E CE   1 
ATOM   2567 H  HA   . MET   B 2 1   ? 0.39865   -7.84057  7.08226  1.000 111.64480 ? 1115 MET   E HA   1 
ATOM   2568 H  HB2  . MET   B 2 1   ? -1.92930  -6.56727  6.23189  1.000 126.63047 ? 1115 MET   E HB2  1 
ATOM   2569 H  HB3  . MET   B 2 1   ? -1.95844  -7.07779  7.73652  1.000 126.63047 ? 1115 MET   E HB3  1 
ATOM   2570 H  HG2  . MET   B 2 1   ? 0.04639   -5.37667  6.83377  1.000 100.03832 ? 1115 MET   E HG2  1 
ATOM   2571 H  HG3  . MET   B 2 1   ? -1.32155  -4.81049  7.41135  1.000 100.03832 ? 1115 MET   E HG3  1 
ATOM   2572 H  HE1  . MET   B 2 1   ? 0.21656   -3.73977  10.41970 1.000 61.72767  ? 1115 MET   E HE1  1 
ATOM   2573 H  HE2  . MET   B 2 1   ? 0.66569   -3.42397  8.92904  1.000 61.72767  ? 1115 MET   E HE2  1 
ATOM   2574 H  HE3  . MET   B 2 1   ? -0.87843  -3.49038  9.29618  1.000 61.72767  ? 1115 MET   E HE3  1 
ATOM   2575 N  N    . ALA   B 2 2   ? -0.53970  -9.84394  8.12542  1.000 83.11921  ? 1116 ALA   E N    1 
ATOM   2576 C  CA   . ALA   B 2 2   ? -1.14994  -11.00013 8.75640  1.000 82.44145  ? 1116 ALA   E CA   1 
ATOM   2577 C  C    . ALA   B 2 2   ? -2.17163  -10.54619 9.79217  1.000 85.29157  ? 1116 ALA   E C    1 
ATOM   2578 O  O    . ALA   B 2 2   ? -2.36592  -9.35016  10.04728 1.000 83.90820  ? 1116 ALA   E O    1 
ATOM   2579 C  CB   . ALA   B 2 2   ? -0.08952  -11.88594 9.40490  1.000 68.12119  ? 1116 ALA   E CB   1 
ATOM   2580 H  H    . ALA   B 2 2   ? 0.21371   -9.61318  8.46997  1.000 99.75833  ? 1116 ALA   E H    1 
ATOM   2581 H  HA   . ALA   B 2 2   ? -1.60071  -11.51884 8.07182  1.000 98.94501  ? 1116 ALA   E HA   1 
ATOM   2582 H  HB1  . ALA   B 2 2   ? -0.52360  -12.65253 9.81087  1.000 81.76071  ? 1116 ALA   E HB1  1 
ATOM   2583 H  HB2  . ALA   B 2 2   ? 0.53465   -12.18154 8.72377  1.000 81.76071  ? 1116 ALA   E HB2  1 
ATOM   2584 H  HB3  . ALA   B 2 2   ? 0.37859   -11.37358 10.08258 1.000 81.76071  ? 1116 ALA   E HB3  1 
ATOM   2585 N  N    . HIS   B 2 3   ? -2.83767  -11.51825 10.39482 1.000 83.68115  ? 1117 HIS   E N    1 
ATOM   2586 C  CA   . HIS   B 2 3   ? -3.74999  -11.27816 11.49320 1.000 79.09826  ? 1117 HIS   E CA   1 
ATOM   2587 C  C    . HIS   B 2 3   ? -3.09109  -11.71831 12.78595 1.000 68.64839  ? 1117 HIS   E C    1 
ATOM   2588 O  O    . HIS   B 2 3   ? -2.23326  -12.60543 12.79004 1.000 62.06577  ? 1117 HIS   E O    1 
ATOM   2589 C  CB   . HIS   B 2 3   ? -5.05135  -12.03301 11.29218 1.000 87.68366  ? 1117 HIS   E CB   1 
ATOM   2590 C  CG   . HIS   B 2 3   ? -5.74237  -11.68622 10.01571 1.000 97.82989  ? 1117 HIS   E CG   1 
ATOM   2591 N  ND1  . HIS   B 2 3   ? -5.36227  -12.21176 8.80043  1.000 100.65815 ? 1117 HIS   E ND1  1 
ATOM   2592 C  CD2  . HIS   B 2 3   ? -6.77742  -10.85207 9.76086  1.000 92.38106  ? 1117 HIS   E CD2  1 
ATOM   2593 C  CE1  . HIS   B 2 3   ? -6.14135  -11.72342 7.85168  1.000 100.10520 ? 1117 HIS   E CE1  1 
ATOM   2594 N  NE2  . HIS   B 2 3   ? -7.00791  -10.89588 8.40815  1.000 93.60778  ? 1117 HIS   E NE2  1 
ATOM   2595 H  H    . HIS   B 2 3   ? -2.77400  -12.34777 10.17702 1.000 100.43265 ? 1117 HIS   E H    1 
ATOM   2596 H  HA   . HIS   B 2 3   ? -3.96205  -10.33362 11.55473 1.000 94.93318  ? 1117 HIS   E HA   1 
ATOM   2597 H  HB2  . HIS   B 2 3   ? -4.86364  -12.98460 11.28069 1.000 105.23567 ? 1117 HIS   E HB2  1 
ATOM   2598 H  HB3  . HIS   B 2 3   ? -5.65262  -11.82226 12.02358 1.000 105.23567 ? 1117 HIS   E HB3  1 
ATOM   2599 H  HD2  . HIS   B 2 3   ? -7.24458  -10.34468 10.38473 1.000 110.87254 ? 1117 HIS   E HD2  1 
ATOM   2600 H  HE1  . HIS   B 2 3   ? -6.08869  -11.92756 6.94589  1.000 120.14152 ? 1117 HIS   E HE1  1 
ATOM   2601 H  HE2  . HIS   B 2 3   ? -7.61762  -10.45591 7.99067  1.000 112.34461 ? 1117 HIS   E HE2  1 
ATOM   2602 N  N    . SER   B 2 4   ? -3.48516  -11.07913 13.88077 1.000 69.12839  ? 1118 SER   E N    1 
ATOM   2603 C  CA   . SER   B 2 4   ? -3.04280  -11.54528 15.18042 1.000 72.01138  ? 1118 SER   E CA   1 
ATOM   2604 C  C    . SER   B 2 4   ? -3.51044  -12.98569 15.37614 1.000 75.12562  ? 1118 SER   E C    1 
ATOM   2605 O  O    . SER   B 2 4   ? -4.44816  -13.43566 14.71350 1.000 70.34422  ? 1118 SER   E O    1 
ATOM   2606 C  CB   . SER   B 2 4   ? -3.59355  -10.65337 16.29282 1.000 57.36684  ? 1118 SER   E CB   1 
ATOM   2607 O  OG   . SER   B 2 4   ? -3.45862  -9.29218  15.94763 1.000 65.91365  ? 1118 SER   E OG   1 
ATOM   2608 H  H    . SER   B 2 4   ? -3.99735  -10.38843 13.89463 1.000 82.96934  ? 1118 SER   E H    1 
ATOM   2609 H  HA   . SER   B 2 4   ? -2.07490  -11.51296 15.23546 1.000 86.42893  ? 1118 SER   E HA   1 
ATOM   2610 H  HB2  . SER   B 2 4   ? -4.53303  -10.85527 16.42522 1.000 68.85548  ? 1118 SER   E HB2  1 
ATOM   2611 H  HB3  . SER   B 2 4   ? -3.09925  -10.82378 17.10984 1.000 68.85548  ? 1118 SER   E HB3  1 
ATOM   2612 H  HG   . SER   B 2 4   ? -3.78899  -8.80890  16.55004 1.000 79.11166  ? 1118 SER   E HG   1 
ATOM   2613 N  N    . PRO   B 2 5   ? -2.85807  -13.73654 16.26004 1.000 80.16932  ? 1119 PRO   E N    1 
ATOM   2614 C  CA   . PRO   B 2 5   ? -3.41270  -15.02836 16.67839 1.000 74.42919  ? 1119 PRO   E CA   1 
ATOM   2615 C  C    . PRO   B 2 5   ? -4.82812  -14.84184 17.18069 1.000 62.94867  ? 1119 PRO   E C    1 
ATOM   2616 O  O    . PRO   B 2 5   ? -5.11296  -13.83295 17.84112 1.000 69.55998  ? 1119 PRO   E O    1 
ATOM   2617 C  CB   . PRO   B 2 5   ? -2.47461  -15.46965 17.80968 1.000 59.04707  ? 1119 PRO   E CB   1 
ATOM   2618 C  CG   . PRO   B 2 5   ? -1.20074  -14.81982 17.49573 1.000 63.42689  ? 1119 PRO   E CG   1 
ATOM   2619 C  CD   . PRO   B 2 5   ? -1.56005  -13.47106 16.90407 1.000 67.50632  ? 1119 PRO   E CD   1 
ATOM   2620 H  HA   . PRO   B 2 5   ? -3.38641  -15.68108 15.96134 1.000 89.33030  ? 1119 PRO   E HA   1 
ATOM   2621 H  HB2  . PRO   B 2 5   ? -2.81944  -15.16871 18.66491 1.000 70.87176  ? 1119 PRO   E HB2  1 
ATOM   2622 H  HB3  . PRO   B 2 5   ? -2.38403  -16.43541 17.80975 1.000 70.87176  ? 1119 PRO   E HB3  1 
ATOM   2623 H  HG2  . PRO   B 2 5   ? -0.67983  -14.71160 18.30680 1.000 76.12754  ? 1119 PRO   E HG2  1 
ATOM   2624 H  HG3  . PRO   B 2 5   ? -0.70881  -15.35636 16.85461 1.000 76.12754  ? 1119 PRO   E HG3  1 
ATOM   2625 H  HD2  . PRO   B 2 5   ? -1.64730  -12.79907 17.59813 1.000 81.02286  ? 1119 PRO   E HD2  1 
ATOM   2626 H  HD3  . PRO   B 2 5   ? -0.89926  -13.19041 16.25177 1.000 81.02286  ? 1119 PRO   E HD3  1 
ATOM   2627 N  N    . PRO   B 2 6   ? -5.73648  -15.78128 16.90455 1.000 65.40670  ? 1120 PRO   E N    1 
ATOM   2628 C  CA   . PRO   B 2 6   ? -7.14731  -15.56074 17.25724 1.000 65.73028  ? 1120 PRO   E CA   1 
ATOM   2629 C  C    . PRO   B 2 6   ? -7.33520  -15.24098 18.73609 1.000 63.53438  ? 1120 PRO   E C    1 
ATOM   2630 O  O    . PRO   B 2 6   ? -6.70022  -15.83356 19.61220 1.000 66.94103  ? 1120 PRO   E O    1 
ATOM   2631 C  CB   . PRO   B 2 6   ? -7.81819  -16.88430 16.86439 1.000 61.52033  ? 1120 PRO   E CB   1 
ATOM   2632 C  CG   . PRO   B 2 6   ? -6.97582  -17.41349 15.77707 1.000 68.03045  ? 1120 PRO   E CG   1 
ATOM   2633 C  CD   . PRO   B 2 6   ? -5.55784  -17.02628 16.13559 1.000 63.87220  ? 1120 PRO   E CD   1 
ATOM   2634 H  HA   . PRO   B 2 6   ? -7.51587  -14.83303 16.73235 1.000 78.89161  ? 1120 PRO   E HA   1 
ATOM   2635 H  HB2  . PRO   B 2 6   ? -7.83030  -17.48897 17.62276 1.000 73.83967  ? 1120 PRO   E HB2  1 
ATOM   2636 H  HB3  . PRO   B 2 6   ? -8.72327  -16.71992 16.55666 1.000 73.83967  ? 1120 PRO   E HB3  1 
ATOM   2637 H  HG2  . PRO   B 2 6   ? -7.06812  -18.37795 15.73016 1.000 81.65182  ? 1120 PRO   E HG2  1 
ATOM   2638 H  HG3  . PRO   B 2 6   ? -7.23928  -17.01358 14.93353 1.000 81.65182  ? 1120 PRO   E HG3  1 
ATOM   2639 H  HD2  . PRO   B 2 6   ? -5.13885  -17.71171 16.67921 1.000 76.66192  ? 1120 PRO   E HD2  1 
ATOM   2640 H  HD3  . PRO   B 2 6   ? -5.03016  -16.86732 15.33735 1.000 76.66192  ? 1120 PRO   E HD3  1 
ATOM   2641 N  N    . GLY   B 2 7   ? -8.21400  -14.27747 19.00143 1.000 59.00394  ? 1121 GLY   E N    1 
ATOM   2642 C  CA   . GLY   B 2 7   ? -8.39937  -13.76812 20.34101 1.000 60.44299  ? 1121 GLY   E CA   1 
ATOM   2643 C  C    . GLY   B 2 7   ? -7.20501  -13.04745 20.92328 1.000 55.21197  ? 1121 GLY   E C    1 
ATOM   2644 O  O    . GLY   B 2 7   ? -7.13393  -12.90396 22.13943 1.000 59.88852  ? 1121 GLY   E O    1 
ATOM   2645 H  H    . GLY   B 2 7   ? -8.71684  -13.90270 18.41296 1.000 70.82000  ? 1121 GLY   E H    1 
ATOM   2646 H  HA2  . GLY   B 2 7   ? -9.14466  -13.14729 20.33603 1.000 72.54686  ? 1121 GLY   E HA2  1 
ATOM   2647 H  HA3  . GLY   B 2 7   ? -8.61078  -14.51062 20.92829 1.000 72.54686  ? 1121 GLY   E HA3  1 
ATOM   2648 N  N    . HIS   B 2 8   ? -6.26969  -12.57828 20.09553 1.000 49.20282  ? 1122 HIS   E N    1 
ATOM   2649 C  CA   . HIS   B 2 8   ? -5.13646  -11.78064 20.54933 1.000 49.18259  ? 1122 HIS   E CA   1 
ATOM   2650 C  C    . HIS   B 2 8   ? -4.97173  -10.50607 19.71937 1.000 48.73767  ? 1122 HIS   E C    1 
ATOM   2651 O  O    . HIS   B 2 8   ? -5.51889  -10.36172 18.62205 1.000 43.89426  ? 1122 HIS   E O    1 
ATOM   2652 C  CB   . HIS   B 2 8   ? -3.82984  -12.57823 20.49139 1.000 54.65969  ? 1122 HIS   E CB   1 
ATOM   2653 C  CG   . HIS   B 2 8   ? -3.79192  -13.74442 21.42512 1.000 64.97870  ? 1122 HIS   E CG   1 
ATOM   2654 N  ND1  . HIS   B 2 8   ? -4.44996  -14.93091 21.17162 1.000 60.12316  ? 1122 HIS   E ND1  1 
ATOM   2655 C  CD2  . HIS   B 2 8   ? -3.17338  -13.90367 22.61789 1.000 59.34892  ? 1122 HIS   E CD2  1 
ATOM   2656 C  CE1  . HIS   B 2 8   ? -4.24007  -15.76689 22.17126 1.000 68.95464  ? 1122 HIS   E CE1  1 
ATOM   2657 N  NE2  . HIS   B 2 8   ? -3.46169  -15.17216 23.05658 1.000 65.97196  ? 1122 HIS   E NE2  1 
ATOM   2658 H  H    . HIS   B 2 8   ? -6.27252  -12.71373 19.24626 1.000 59.05867  ? 1122 HIS   E H    1 
ATOM   2659 H  HA   . HIS   B 2 8   ? -5.31774  -11.51107 21.46332 1.000 59.03439  ? 1122 HIS   E HA   1 
ATOM   2660 H  HB2  . HIS   B 2 8   ? -3.71136  -12.91703 19.59024 1.000 65.60690  ? 1122 HIS   E HB2  1 
ATOM   2661 H  HB3  . HIS   B 2 8   ? -3.09485  -11.98941 20.72376 1.000 65.60690  ? 1122 HIS   E HB3  1 
ATOM   2662 H  HD1  . HIS   B 2 8   ? -4.92214  -15.09896 20.47275 1.000 72.16307  ? 1122 HIS   E HD1  1 
ATOM   2663 H  HD2  . HIS   B 2 8   ? -2.65105  -13.27242 23.05788 1.000 71.23398  ? 1122 HIS   E HD2  1 
ATOM   2664 H  HE1  . HIS   B 2 8   ? -4.58244  -16.62882 22.24032 1.000 82.76085  ? 1122 HIS   E HE1  1 
ATOM   2665 N  N    . HIS   B 2 9   ? -4.18103  -9.57466  20.26759 1.000 43.61856  ? 1123 HIS   E N    1 
ATOM   2666 C  CA   . HIS   B 2 9   ? -3.99196  -8.25971  19.67848 1.000 41.32428  ? 1123 HIS   E CA   1 
ATOM   2667 C  C    . HIS   B 2 9   ? -2.55166  -7.97058  19.30490 1.000 43.86223  ? 1123 HIS   E C    1 
ATOM   2668 O  O    . HIS   B 2 9   ? -2.28410  -6.92966  18.68025 1.000 36.73459  ? 1123 HIS   E O    1 
ATOM   2669 C  CB   . HIS   B 2 9   ? -4.46675  -7.16813  20.64952 1.000 37.90118  ? 1123 HIS   E CB   1 
ATOM   2670 C  CG   . HIS   B 2 9   ? -5.88771  -7.32182  21.07035 1.000 37.21853  ? 1123 HIS   E CG   1 
ATOM   2671 N  ND1  . HIS   B 2 9   ? -6.24711  -7.82481  22.29875 1.000 42.39083  ? 1123 HIS   E ND1  1 
ATOM   2672 C  CD2  . HIS   B 2 9   ? -7.04423  -7.05424  20.41732 1.000 39.90349  ? 1123 HIS   E CD2  1 
ATOM   2673 C  CE1  . HIS   B 2 9   ? -7.56775  -7.83627  22.39712 1.000 50.55912  ? 1123 HIS   E CE1  1 
ATOM   2674 N  NE2  . HIS   B 2 9   ? -8.07503  -7.37767  21.26710 1.000 41.51695  ? 1123 HIS   E NE2  1 
ATOM   2675 H  H    . HIS   B 2 9   ? -3.73788  -9.69053  20.99546 1.000 52.35755  ? 1123 HIS   E H    1 
ATOM   2676 H  HA   . HIS   B 2 9   ? -4.53093  -8.20190  18.87408 1.000 49.60441  ? 1123 HIS   E HA   1 
ATOM   2677 H  HB2  . HIS   B 2 9   ? -3.91596  -7.19844  21.44740 1.000 45.49669  ? 1123 HIS   E HB2  1 
ATOM   2678 H  HB3  . HIS   B 2 9   ? -4.37703  -6.30451  20.21706 1.000 45.49669  ? 1123 HIS   E HB3  1 
ATOM   2679 H  HD2  . HIS   B 2 9   ? -7.12547  -6.71510  19.55518 1.000 47.89946  ? 1123 HIS   E HD2  1 
ATOM   2680 H  HE1  . HIS   B 2 9   ? -8.05543  -8.11931  23.13669 1.000 60.68622  ? 1123 HIS   E HE1  1 
ATOM   2681 H  HE2  . HIS   B 2 9   ? -8.91290  -7.29499  21.09177 1.000 49.83561  ? 1123 HIS   E HE2  1 
ATOM   2682 N  N    . SER   B 2 10  ? -1.62951  -8.84001  19.68341 1.000 37.50033  ? 1124 SER   E N    1 
ATOM   2683 C  CA   . SER   B 2 10  ? -0.21246  -8.66110  19.41889 1.000 39.49708  ? 1124 SER   E CA   1 
ATOM   2684 C  C    . SER   B 2 10  ? 0.47234   -9.96027  19.78612 1.000 41.82768  ? 1124 SER   E C    1 
ATOM   2685 O  O    . SER   B 2 10  ? -0.16663  -10.91983 20.22573 1.000 37.37696  ? 1124 SER   E O    1 
ATOM   2686 C  CB   . SER   B 2 10  ? 0.37233   -7.50578  20.21715 1.000 39.09111  ? 1124 SER   E CB   1 
ATOM   2687 O  OG   . SER   B 2 10  ? 0.20495   -7.73705  21.59578 1.000 39.69435  ? 1124 SER   E OG   1 
ATOM   2688 H  H    . SER   B 2 10  ? -1.80548  -9.56608  20.10940 1.000 45.01567  ? 1124 SER   E H    1 
ATOM   2689 H  HA   . SER   B 2 10  ? -0.08667  -8.47714  18.47483 1.000 47.41177  ? 1124 SER   E HA   1 
ATOM   2690 H  HB2  . SER   B 2 10  ? 1.31883   -7.42855  20.01947 1.000 46.92461  ? 1124 SER   E HB2  1 
ATOM   2691 H  HB3  . SER   B 2 10  ? -0.08543  -6.68602  19.97354 1.000 46.92461  ? 1124 SER   E HB3  1 
ATOM   2692 H  HG   . SER   B 2 10  ? -0.61294  -7.77325  21.78379 1.000 47.64849  ? 1124 SER   E HG   1 
ATOM   2693 N  N    . VAL   B 2 11  ? 1.78691   -9.96807  19.60979 1.000 41.17919  ? 1125 VAL   E N    1 
ATOM   2694 C  CA   . VAL   B 2 11  ? 2.65319   -11.08304 19.95107 1.000 33.72703  ? 1125 VAL   E CA   1 
ATOM   2695 C  C    . VAL   B 2 11  ? 3.84879   -10.50978 20.68137 1.000 40.15630  ? 1125 VAL   E C    1 
ATOM   2696 O  O    . VAL   B 2 11  ? 4.42085   -9.51088  20.23908 1.000 44.43949  ? 1125 VAL   E O    1 
ATOM   2697 C  CB   . VAL   B 2 11  ? 3.10704   -11.85123 18.70143 1.000 46.20995  ? 1125 VAL   E CB   1 
ATOM   2698 C  CG1  . VAL   B 2 11  ? 4.20341   -12.83074 19.05596 1.000 41.48846  ? 1125 VAL   E CG1  1 
ATOM   2699 C  CG2  . VAL   B 2 11  ? 1.92098   -12.54133 18.08158 1.000 44.23106  ? 1125 VAL   E CG2  1 
ATOM   2700 H  H    . VAL   B 2 11  ? 2.22032   -9.30405  19.27687 1.000 49.43031  ? 1125 VAL   E H    1 
ATOM   2701 H  HA   . VAL   B 2 11  ? 2.18763   -11.70292 20.53407 1.000 40.48771  ? 1125 VAL   E HA   1 
ATOM   2702 H  HB   . VAL   B 2 11  ? 3.47446   -11.23711 18.04664 1.000 55.46722  ? 1125 VAL   E HB   1 
ATOM   2703 H  HG11 . VAL   B 2 11  ? 4.30103   -13.47057 18.33347 1.000 49.80142  ? 1125 VAL   E HG11 1 
ATOM   2704 H  HG12 . VAL   B 2 11  ? 5.03316   -12.34421 19.18131 1.000 49.80142  ? 1125 VAL   E HG12 1 
ATOM   2705 H  HG13 . VAL   B 2 11  ? 3.96287   -13.29105 19.87520 1.000 49.80142  ? 1125 VAL   E HG13 1 
ATOM   2706 H  HG21 . VAL   B 2 11  ? 2.20232   -12.97820 17.26250 1.000 53.09254  ? 1125 VAL   E HG21 1 
ATOM   2707 H  HG22 . VAL   B 2 11  ? 1.57653   -13.19906 18.70580 1.000 53.09254  ? 1125 VAL   E HG22 1 
ATOM   2708 H  HG23 . VAL   B 2 11  ? 1.23781   -11.88095 17.88643 1.000 53.09254  ? 1125 VAL   E HG23 1 
ATOM   2709 N  N    . THR   B 2 12  ? 4.14508   -11.07428 21.85087 1.000 38.36620  ? 1126 THR   E N    1 
ATOM   2710 C  CA   . THR   B 2 12  ? 5.37741   -10.80811 22.58249 1.000 37.27462  ? 1126 THR   E CA   1 
ATOM   2711 C  C    . THR   B 2 12  ? 6.40523   -11.86878 22.20661 1.000 47.55612  ? 1126 THR   E C    1 
ATOM   2712 O  O    . THR   B 2 12  ? 6.14408   -13.06630 22.34229 1.000 51.31700  ? 1126 THR   E O    1 
ATOM   2713 C  CB   . THR   B 2 12  ? 5.13870   -10.86764 24.08495 1.000 38.12278  ? 1126 THR   E CB   1 
ATOM   2714 O  OG1  . THR   B 2 12  ? 4.12172   -9.93953  24.46776 1.000 39.24877  ? 1126 THR   E OG1  1 
ATOM   2715 C  CG2  . THR   B 2 12  ? 6.42823   -10.59145 24.82004 1.000 42.30332  ? 1126 THR   E CG2  1 
ATOM   2716 H  H    . THR   B 2 12  ? 3.62980   -11.63332 22.25282 1.000 46.05471  ? 1126 THR   E H    1 
ATOM   2717 H  HA   . THR   B 2 12  ? 5.70332   -9.92579  22.34545 1.000 44.74482  ? 1126 THR   E HA   1 
ATOM   2718 H  HB   . THR   B 2 12  ? 4.83348   -11.75343 24.33620 1.000 45.76261  ? 1126 THR   E HB   1 
ATOM   2719 H  HG1  . THR   B 2 12  ? 4.26963   -9.19057  24.11735 1.000 47.11380  ? 1126 THR   E HG1  1 
ATOM   2720 H  HG21 . THR   B 2 12  ? 6.25029   -10.46110 25.76462 1.000 50.77926  ? 1126 THR   E HG21 1 
ATOM   2721 H  HG22 . THR   B 2 12  ? 7.03692   -11.33930 24.71463 1.000 50.77926  ? 1126 THR   E HG22 1 
ATOM   2722 H  HG23 . THR   B 2 12  ? 6.84754   -9.79187  24.46543 1.000 50.77926  ? 1126 THR   E HG23 1 
ATOM   2723 N  N    . GLY   B 2 13  ? 7.55614   -11.44116 21.73392 1.000 46.94362  ? 1127 GLY   E N    1 
ATOM   2724 C  CA   . GLY   B 2 13  ? 8.65235   -12.35675 21.54296 1.000 55.85288  ? 1127 GLY   E CA   1 
ATOM   2725 C  C    . GLY   B 2 13  ? 9.51171   -12.34081 22.77894 1.000 48.96529  ? 1127 GLY   E C    1 
ATOM   2726 O  O    . GLY   B 2 13  ? 10.18469  -11.34426 23.04009 1.000 55.73383  ? 1127 GLY   E O    1 
ATOM   2727 H  H    . GLY   B 2 13  ? 7.72583   -10.62647 21.51692 1.000 56.34761  ? 1127 GLY   E H    1 
ATOM   2728 H  HA2  . GLY   B 2 13  ? 8.31742   -13.25504 21.39534 1.000 67.03873  ? 1127 GLY   E HA2  1 
ATOM   2729 H  HA3  . GLY   B 2 13  ? 9.18431   -12.08830 20.77755 1.000 67.03873  ? 1127 GLY   E HA3  1 
ATOM   2730 N  N    . ARG   B 2 14  ? 9.47791   -13.39737 23.55330 1.000 55.33183  ? 1128 ARG   E N    1 
ATOM   2731 C  CA   . ARG   B 2 14  ? 10.25179  -13.42508 24.79069 1.000 61.78500  ? 1128 ARG   E CA   1 
ATOM   2732 C  C    . ARG   B 2 14  ? 11.70477  -13.80115 24.49541 1.000 61.35954  ? 1128 ARG   E C    1 
ATOM   2733 O  O    . ARG   B 2 14  ? 11.96266  -14.73589 23.74581 1.000 73.19424  ? 1128 ARG   E O    1 
ATOM   2734 C  CB   . ARG   B 2 14  ? 9.67877   -14.43765 25.76541 1.000 62.29040  ? 1128 ARG   E CB   1 
ATOM   2735 C  CG   . ARG   B 2 14  ? 8.50705   -13.95270 26.55491 1.000 67.08247  ? 1128 ARG   E CG   1 
ATOM   2736 C  CD   . ARG   B 2 14  ? 8.31250   -14.87229 27.76843 1.000 75.50775  ? 1128 ARG   E CD   1 
ATOM   2737 N  NE   . ARG   B 2 14  ? 9.25510   -14.66091 28.87308 1.000 71.31282  ? 1128 ARG   E NE   1 
ATOM   2738 C  CZ   . ARG   B 2 14  ? 9.19565   -13.62371 29.70661 1.000 73.18654  ? 1128 ARG   E CZ   1 
ATOM   2739 N  NH1  . ARG   B 2 14  ? 8.36152   -12.61596 29.49108 1.000 70.13492  ? 1128 ARG   E NH1  1 
ATOM   2740 N  NH2  . ARG   B 2 14  ? 9.98992   -13.59194 30.78186 1.000 62.56174  ? 1128 ARG   E NH2  1 
ATOM   2741 H  H    . ARG   B 2 14  ? 9.02268   -14.10990 23.39621 1.000 66.41347  ? 1128 ARG   E H    1 
ATOM   2742 H  HA   . ARG   B 2 14  ? 10.22325  -12.54587 25.19943 1.000 74.15728  ? 1128 ARG   E HA   1 
ATOM   2743 H  HB2  . ARG   B 2 14  ? 9.39117   -15.21758 25.26552 1.000 74.76375  ? 1128 ARG   E HB2  1 
ATOM   2744 H  HB3  . ARG   B 2 14  ? 10.37314  -14.68518 26.39587 1.000 74.76375  ? 1128 ARG   E HB3  1 
ATOM   2745 H  HG2  . ARG   B 2 14  ? 8.66868   -13.04840 26.86638 1.000 80.51425  ? 1128 ARG   E HG2  1 
ATOM   2746 H  HG3  . ARG   B 2 14  ? 7.70612   -13.97713 26.00827 1.000 80.51425  ? 1128 ARG   E HG3  1 
ATOM   2747 H  HD2  . ARG   B 2 14  ? 7.41944   -14.73122 28.11978 1.000 90.62458  ? 1128 ARG   E HD2  1 
ATOM   2748 H  HD3  . ARG   B 2 14  ? 8.41235   -15.79158 27.47543 1.000 90.62458  ? 1128 ARG   E HD3  1 
ATOM   2749 H  HE   . ARG   B 2 14  ? 9.88104   -15.23919 28.98876 1.000 85.59066  ? 1128 ARG   E HE   1 
ATOM   2750 H  HH11 . ARG   B 2 14  ? 7.84592   -12.62422 28.80283 1.000 84.17718  ? 1128 ARG   E HH11 1 
ATOM   2751 H  HH12 . ARG   B 2 14  ? 8.33606   -11.95402 30.03952 1.000 84.17718  ? 1128 ARG   E HH12 1 
ATOM   2752 H  HH21 . ARG   B 2 14  ? 10.53577  -14.23920 30.93252 1.000 75.08936  ? 1128 ARG   E HH21 1 
ATOM   2753 H  HH22 . ARG   B 2 14  ? 9.95491   -12.92424 31.32274 1.000 75.08936  ? 1128 ARG   E HH22 1 
ATOM   2754 N  N    . PRO   B 2 15  ? 12.66397  -13.10154 25.09860 1.000 59.40654  ? 1129 PRO   E N    1 
ATOM   2755 C  CA   . PRO   B 2 15  ? 14.07250  -13.51767 24.95004 1.000 65.94628  ? 1129 PRO   E CA   1 
ATOM   2756 C  C    . PRO   B 2 15  ? 14.31177  -14.83522 25.67561 1.000 76.01000  ? 1129 PRO   E C    1 
ATOM   2757 O  O    . PRO   B 2 15  ? 14.02042  -14.96455 26.86339 1.000 78.89165  ? 1129 PRO   E O    1 
ATOM   2758 C  CB   . PRO   B 2 15  ? 14.84910  -12.36441 25.59148 1.000 63.08323  ? 1129 PRO   E CB   1 
ATOM   2759 C  CG   . PRO   B 2 15  ? 13.85172  -11.78567 26.64073 1.000 64.90268  ? 1129 PRO   E CG   1 
ATOM   2760 C  CD   . PRO   B 2 15  ? 12.47548  -12.01033 26.07358 1.000 60.01826  ? 1129 PRO   E CD   1 
ATOM   2761 H  HA   . PRO   B 2 15  ? 14.32447  -13.60071 24.01702 1.000 79.15081  ? 1129 PRO   E HA   1 
ATOM   2762 H  HB2  . PRO   B 2 15  ? 15.65386  -12.69825 26.01786 1.000 75.71515  ? 1129 PRO   E HB2  1 
ATOM   2763 H  HB3  . PRO   B 2 15  ? 15.07907  -11.70152 24.92171 1.000 75.71515  ? 1129 PRO   E HB3  1 
ATOM   2764 H  HG2  . PRO   B 2 15  ? 13.95603  -12.25438 27.48354 1.000 77.89850  ? 1129 PRO   E HG2  1 
ATOM   2765 H  HG3  . PRO   B 2 15  ? 14.02120  -10.83865 26.76460 1.000 77.89850  ? 1129 PRO   E HG3  1 
ATOM   2766 H  HD2  . PRO   B 2 15  ? 11.85703  -12.27769 26.77139 1.000 72.03718  ? 1129 PRO   E HD2  1 
ATOM   2767 H  HD3  . PRO   B 2 15  ? 12.15192  -11.20925 25.63258 1.000 72.03718  ? 1129 PRO   E HD3  1 
ATOM   2768 N  N    . SER   B 2 16  ? 14.83550  -15.82063 24.94946 1.000 82.33143  ? 1130 SER   E N    1 
ATOM   2769 C  CA   . SER   B 2 16  ? 14.90298  -17.19788 25.44073 1.000 101.19579 ? 1130 SER   E CA   1 
ATOM   2770 C  C    . SER   B 2 16  ? 16.30152  -17.58851 25.89631 1.000 100.49377 ? 1130 SER   E C    1 
ATOM   2771 O  O    . SER   B 2 16  ? 16.47177  -18.09519 27.00780 1.000 120.52491 ? 1130 SER   E O    1 
ATOM   2772 C  CB   . SER   B 2 16  ? 14.42142  -18.17571 24.35350 1.000 123.52141 ? 1130 SER   E CB   1 
ATOM   2773 O  OG   . SER   B 2 16  ? 14.57825  -19.53098 24.72742 1.000 132.88764 ? 1130 SER   E OG   1 
ATOM   2774 H  H    . SER   B 2 16  ? 15.16199  -15.71639 24.16070 1.000 98.81299  ? 1130 SER   E H    1 
ATOM   2775 H  HA   . SER   B 2 16  ? 14.30700  -17.27925 26.20170 1.000 121.45022 ? 1130 SER   E HA   1 
ATOM   2776 H  HB2  . SER   B 2 16  ? 13.48076  -18.00966 24.18471 1.000 148.24097 ? 1130 SER   E HB2  1 
ATOM   2777 H  HB3  . SER   B 2 16  ? 14.93626  -18.01722 23.54683 1.000 148.24097 ? 1130 SER   E HB3  1 
ATOM   2778 H  HG   . SER   B 2 16  ? 14.24502  -20.03130 24.14070 1.000 159.48045 ? 1130 SER   E HG   1 
ATOM   2779 N  N    . VAL   B 2 17  ? 17.30344  -17.35527 25.05960 1.000 108.24347 ? 1131 VAL   E N    1 
ATOM   2780 C  CA   . VAL   B 2 17  ? 18.67088  -17.73513 25.35352 1.000 93.79278  ? 1131 VAL   E CA   1 
ATOM   2781 C  C    . VAL   B 2 17  ? 19.45459  -16.55545 25.90257 1.000 94.34963  ? 1131 VAL   E C    1 
ATOM   2782 O  O    . VAL   B 2 17  ? 20.09325  -16.65259 26.95290 1.000 98.45415  ? 1131 VAL   E O    1 
ATOM   2783 C  CB   . VAL   B 2 17  ? 19.33897  -18.32183 24.08833 1.000 100.66916 ? 1131 VAL   E CB   1 
ATOM   2784 H  H    . VAL   B 2 17  ? 17.21057  -16.96843 24.29714 1.000 129.90744 ? 1131 VAL   E H    1 
ATOM   2785 H  HA   . VAL   B 2 17  ? 18.66815  -18.42811 26.03225 1.000 112.56661 ? 1131 VAL   E HA   1 
ATOM   2786 N  N    . ASN   B 2 18  ? 19.38337  -15.41596 25.21530 1.000 104.76567 ? 1132 ASN   E N    1 
ATOM   2787 C  CA   . ASN   B 2 18  ? 20.13211  -14.22688 25.60450 1.000 94.22448  ? 1132 ASN   E CA   1 
ATOM   2788 C  C    . ASN   B 2 18  ? 19.69583  -13.72226 26.97307 1.000 88.50268  ? 1132 ASN   E C    1 
ATOM   2789 O  O    . ASN   B 2 18  ? 18.59972  -13.16380 27.11140 1.000 81.23229  ? 1132 ASN   E O    1 
ATOM   2790 C  CB   . ASN   B 2 18  ? 19.94356  -13.12500 24.56507 1.000 81.93030  ? 1132 ASN   E CB   1 
ATOM   2791 C  CG   . ASN   B 2 18  ? 21.14483  -12.21376 24.46549 1.000 83.22235  ? 1132 ASN   E CG   1 
ATOM   2792 O  OD1  . ASN   B 2 18  ? 21.87128  -11.96988 25.45895 1.000 79.41448  ? 1132 ASN   E OD1  1 
ATOM   2793 N  ND2  . ASN   B 2 18  ? 21.38073  -11.70979 23.25466 1.000 71.63421  ? 1132 ASN   E ND2  1 
ATOM   2794 H  H    . ASN   B 2 18  ? 18.90191  -15.30632 24.51119 1.000 125.73408 ? 1132 ASN   E H    1 
ATOM   2795 H  HA   . ASN   B 2 18  ? 21.07350  -14.45528 25.65466 1.000 113.08465 ? 1132 ASN   E HA   1 
ATOM   2796 H  HB2  . ASN   B 2 18  ? 19.80003  -13.53029 23.69556 1.000 98.33164  ? 1132 ASN   E HB2  1 
ATOM   2797 H  HB3  . ASN   B 2 18  ? 19.17572  -12.58544 24.81043 1.000 98.33164  ? 1132 ASN   E HB3  1 
ATOM   2798 H  HD21 . ASN   B 2 18  ? 22.04966  -11.18369 23.13073 1.000 85.97632  ? 1132 ASN   E HD21 1 
ATOM   2799 H  HD22 . ASN   B 2 18  ? 20.86406  -11.91064 22.59716 1.000 85.97632  ? 1132 ASN   E HD22 1 
ATOM   2800 N  N    . GLY   B 2 19  ? 20.53562  -13.91130 27.99008 1.000 76.23849  ? 1133 GLY   E N    1 
ATOM   2801 C  CA   . GLY   B 2 19  ? 20.12442  -13.52648 29.32576 1.000 65.67035  ? 1133 GLY   E CA   1 
ATOM   2802 C  C    . GLY   B 2 19  ? 19.82680  -12.04462 29.46414 1.000 61.58226  ? 1133 GLY   E C    1 
ATOM   2803 O  O    . GLY   B 2 19  ? 18.95379  -11.65280 30.24643 1.000 64.00953  ? 1133 GLY   E O    1 
ATOM   2804 H  H    . GLY   B 2 19  ? 21.32370  -14.25036 27.93026 1.000 91.50146  ? 1133 GLY   E H    1 
ATOM   2805 H  HA2  . GLY   B 2 19  ? 19.32293  -14.01810 29.56411 1.000 78.81970  ? 1133 GLY   E HA2  1 
ATOM   2806 H  HA3  . GLY   B 2 19  ? 20.83068  -13.75145 29.95145 1.000 78.81970  ? 1133 GLY   E HA3  1 
ATOM   2807 N  N    . LEU   B 2 20  ? 20.52998  -11.19799 28.71483 1.000 56.13002  ? 1134 LEU   E N    1 
ATOM   2808 C  CA   . LEU   B 2 20  ? 20.40011  -9.76022  28.90152 1.000 55.65929  ? 1134 LEU   E CA   1 
ATOM   2809 C  C    . LEU   B 2 20  ? 19.36235  -9.09094  27.99301 1.000 59.46998  ? 1134 LEU   E C    1 
ATOM   2810 O  O    . LEU   B 2 20  ? 19.12129  -7.88772  28.13281 1.000 48.76962  ? 1134 LEU   E O    1 
ATOM   2811 C  CB   . LEU   B 2 20  ? 21.76608  -9.11833  28.70294 1.000 54.86194  ? 1134 LEU   E CB   1 
ATOM   2812 C  CG   . LEU   B 2 20  ? 22.80694  -9.55824  29.74557 1.000 54.77661  ? 1134 LEU   E CG   1 
ATOM   2813 C  CD1  . LEU   B 2 20  ? 24.10345  -8.70513  29.68589 1.000 56.21311  ? 1134 LEU   E CD1  1 
ATOM   2814 C  CD2  . LEU   B 2 20  ? 22.23443  -9.53692  31.17157 1.000 55.65981  ? 1134 LEU   E CD2  1 
ATOM   2815 H  H    . LEU   B 2 20  ? 21.08242  -11.43256 28.09889 1.000 67.37130  ? 1134 LEU   E H    1 
ATOM   2816 H  HA   . LEU   B 2 20  ? 20.09990  -9.59139  29.80831 1.000 66.80643  ? 1134 LEU   E HA   1 
ATOM   2817 H  HB2  . LEU   B 2 20  ? 22.10124  -9.36232  27.82599 1.000 65.84960  ? 1134 LEU   E HB2  1 
ATOM   2818 H  HB3  . LEU   B 2 20  ? 21.67050  -8.15507  28.76537 1.000 65.84960  ? 1134 LEU   E HB3  1 
ATOM   2819 H  HG   . LEU   B 2 20  ? 23.04478  -10.47268 29.52617 1.000 65.74720  ? 1134 LEU   E HG   1 
ATOM   2820 H  HD11 . LEU   B 2 20  ? 24.75997  -9.08566  30.29012 1.000 67.47100  ? 1134 LEU   E HD11 1 
ATOM   2821 H  HD12 . LEU   B 2 20  ? 24.44538  -8.71333  28.77819 1.000 67.47100  ? 1134 LEU   E HD12 1 
ATOM   2822 H  HD13 . LEU   B 2 20  ? 23.89586  -7.79602  29.95297 1.000 67.47100  ? 1134 LEU   E HD13 1 
ATOM   2823 H  HD21 . LEU   B 2 20  ? 22.96456  -9.60880  31.80611 1.000 66.80704  ? 1134 LEU   E HD21 1 
ATOM   2824 H  HD22 . LEU   B 2 20  ? 21.75827  -8.70297  31.30827 1.000 66.80704  ? 1134 LEU   E HD22 1 
ATOM   2825 H  HD23 . LEU   B 2 20  ? 21.62752  -10.28587 31.27944 1.000 66.80704  ? 1134 LEU   E HD23 1 
ATOM   2826 N  N    . ALA   B 2 21  ? 18.71817  -9.83296  27.10107 1.000 46.90648  ? 1135 ALA   E N    1 
ATOM   2827 C  CA   . ALA   B 2 21  ? 17.83470  -9.24407  26.12197 1.000 48.42095  ? 1135 ALA   E CA   1 
ATOM   2828 C  C    . ALA   B 2 21  ? 16.45918  -8.99902  26.70691 1.000 47.48324  ? 1135 ALA   E C    1 
ATOM   2829 O  O    . ALA   B 2 21  ? 15.97205  -9.77206  27.52774 1.000 41.95969  ? 1135 ALA   E O    1 
ATOM   2830 C  CB   . ALA   B 2 21  ? 17.69511  -10.14610 24.90645 1.000 39.73736  ? 1135 ALA   E CB   1 
ATOM   2831 H  H    . ALA   B 2 21  ? 18.78034  -10.68895 27.04618 1.000 56.30306  ? 1135 ALA   E H    1 
ATOM   2832 H  HA   . ALA   B 2 21  ? 18.21036  -8.39530  25.84025 1.000 58.12042  ? 1135 ALA   E HA   1 
ATOM   2833 H  HB1  . ALA   B 2 21  ? 17.13122  -9.70712  24.25052 1.000 47.70011  ? 1135 ALA   E HB1  1 
ATOM   2834 H  HB2  . ALA   B 2 21  ? 18.57463  -10.30835 24.53092 1.000 47.70011  ? 1135 ALA   E HB2  1 
ATOM   2835 H  HB3  . ALA   B 2 21  ? 17.29247  -10.98501 25.18031 1.000 47.70011  ? 1135 ALA   E HB3  1 
ATOM   2836 N  N    . LEU   B 2 22  ? 15.83410  -7.91160  26.25241 1.000 41.74130  ? 1136 LEU   E N    1 
ATOM   2837 C  CA   . LEU   B 2 22  ? 14.46580  -7.56479  26.58749 1.000 44.28920  ? 1136 LEU   E CA   1 
ATOM   2838 C  C    . LEU   B 2 22  ? 13.54583  -7.97181  25.44890 1.000 42.87458  ? 1136 LEU   E C    1 
ATOM   2839 O  O    . LEU   B 2 22  ? 13.99575  -8.32386  24.36238 1.000 43.80642  ? 1136 LEU   E O    1 
ATOM   2840 C  CB   . LEU   B 2 22  ? 14.34256  -6.06595  26.84359 1.000 46.25324  ? 1136 LEU   E CB   1 
ATOM   2841 C  CG   . LEU   B 2 22  ? 15.40453  -5.41824  27.73233 1.000 48.61664  ? 1136 LEU   E CG   1 
ATOM   2842 C  CD1  . LEU   B 2 22  ? 15.17241  -3.93542  27.84943 1.000 44.55736  ? 1136 LEU   E CD1  1 
ATOM   2843 C  CD2  . LEU   B 2 22  ? 15.35088  -6.05257  29.07415 1.000 51.01995  ? 1136 LEU   E CD2  1 
ATOM   2844 H  H    . LEU   B 2 22  ? 16.20304  -7.33957  25.72679 1.000 50.10484  ? 1136 LEU   E H    1 
ATOM   2845 H  HA   . LEU   B 2 22  ? 14.20094  -8.03304  27.39463 1.000 53.16232  ? 1136 LEU   E HA   1 
ATOM   2846 H  HB2  . LEU   B 2 22  ? 14.37852  -5.61369  25.98623 1.000 55.51916  ? 1136 LEU   E HB2  1 
ATOM   2847 H  HB3  . LEU   B 2 22  ? 13.48476  -5.90608  27.26729 1.000 55.51916  ? 1136 LEU   E HB3  1 
ATOM   2848 H  HG   . LEU   B 2 22  ? 16.28407  -5.54630  27.34384 1.000 58.35525  ? 1136 LEU   E HG   1 
ATOM   2849 H  HD11 . LEU   B 2 22  ? 15.83875  -3.55748  28.44445 1.000 53.48411  ? 1136 LEU   E HD11 1 
ATOM   2850 H  HD12 . LEU   B 2 22  ? 15.24830  -3.53346  26.96990 1.000 53.48411  ? 1136 LEU   E HD12 1 
ATOM   2851 H  HD13 . LEU   B 2 22  ? 14.28410  -3.78215  28.20764 1.000 53.48411  ? 1136 LEU   E HD13 1 
ATOM   2852 H  HD21 . LEU   B 2 22  ? 16.01587  -5.63836  29.64609 1.000 61.23921  ? 1136 LEU   E HD21 1 
ATOM   2853 H  HD22 . LEU   B 2 22  ? 14.46562  -5.92378  29.44917 1.000 61.23921  ? 1136 LEU   E HD22 1 
ATOM   2854 H  HD23 . LEU   B 2 22  ? 15.53691  -7.00020  28.98315 1.000 61.23921  ? 1136 LEU   E HD23 1 
ATOM   2855 N  N    . ALA   B 2 23  ? 12.23932  -7.84908  25.68719 1.000 42.04782  ? 1137 ALA   E N    1 
ATOM   2856 C  CA   . ALA   B 2 23  ? 11.26002  -8.39590  24.76624 1.000 42.82259  ? 1137 ALA   E CA   1 
ATOM   2857 C  C    . ALA   B 2 23  ? 11.13480  -7.55244  23.51187 1.000 44.95519  ? 1137 ALA   E C    1 
ATOM   2858 O  O    . ALA   B 2 23  ? 11.50781  -6.37408  23.46799 1.000 38.84573  ? 1137 ALA   E O    1 
ATOM   2859 C  CB   . ALA   B 2 23  ? 9.87800   -8.48963  25.41360 1.000 42.59337  ? 1137 ALA   E CB   1 
ATOM   2860 H  H    . ALA   B 2 23  ? 11.90202  -7.45472  26.37298 1.000 50.47266  ? 1137 ALA   E H    1 
ATOM   2861 H  HA   . ALA   B 2 23  ? 11.56055  -9.28484  24.52056 1.000 51.40239  ? 1137 ALA   E HA   1 
ATOM   2862 H  HB1  . ALA   B 2 23  ? 9.25116   -8.85299  24.76866 1.000 51.12732  ? 1137 ALA   E HB1  1 
ATOM   2863 H  HB2  . ALA   B 2 23  ? 9.93072   -9.07167  26.18778 1.000 51.12732  ? 1137 ALA   E HB2  1 
ATOM   2864 H  HB3  . ALA   B 2 23  ? 9.59578   -7.60231  25.68548 1.000 51.12732  ? 1137 ALA   E HB3  1 
ATOM   2865 N  N    . GLU   B 2 24  ? 10.57964  -8.18313  22.48692 1.000 34.66613  ? 1138 GLU   E N    1 
ATOM   2866 C  CA   . GLU   B 2 24  ? 10.22703  -7.57306  21.21289 1.000 40.58216  ? 1138 GLU   E CA   1 
ATOM   2867 C  C    . GLU   B 2 24  ? 8.75025   -7.84580  20.96830 1.000 43.11434  ? 1138 GLU   E C    1 
ATOM   2868 O  O    . GLU   B 2 24  ? 8.23322   -8.86459  21.40647 1.000 41.84546  ? 1138 GLU   E O    1 
ATOM   2869 C  CB   . GLU   B 2 24  ? 11.10581  -8.15658  20.08880 1.000 37.74510  ? 1138 GLU   E CB   1 
ATOM   2870 C  CG   . GLU   B 2 24  ? 12.57998  -7.73275  20.22638 1.000 37.98804  ? 1138 GLU   E CG   1 
ATOM   2871 C  CD   . GLU   B 2 24  ? 13.57220  -8.65679  19.54845 1.000 50.84456  ? 1138 GLU   E CD   1 
ATOM   2872 O  OE1  . GLU   B 2 24  ? 13.22622  -9.27919  18.51559 1.000 61.60145  ? 1138 GLU   E OE1  1 
ATOM   2873 O  OE2  . GLU   B 2 24  ? 14.71648  -8.76558  20.06748 1.000 42.05710  ? 1138 GLU   E OE2  1 
ATOM   2874 H  H    . GLU   B 2 24  ? 10.38453  -9.02048  22.50627 1.000 41.61463  ? 1138 GLU   E H    1 
ATOM   2875 H  HA   . GLU   B 2 24  ? 10.36214  -6.61252  21.21096 1.000 48.71387  ? 1138 GLU   E HA   1 
ATOM   2876 H  HB2  . GLU   B 2 24  ? 11.06441  -9.12510  20.12289 1.000 45.30939  ? 1138 GLU   E HB2  1 
ATOM   2877 H  HB3  . GLU   B 2 24  ? 10.77819  -7.84047  19.23227 1.000 45.30939  ? 1138 GLU   E HB3  1 
ATOM   2878 H  HG2  . GLU   B 2 24  ? 12.68576  -6.85248  19.83289 1.000 45.60093  ? 1138 GLU   E HG2  1 
ATOM   2879 H  HG3  . GLU   B 2 24  ? 12.80585  -7.70398  21.16928 1.000 45.60093  ? 1138 GLU   E HG3  1 
ATOM   2880 N  N    . TYR   B 2 25  ? 8.05248   -6.93324  20.29370 1.000 35.66944  ? 1139 TYR   E N    1 
ATOM   2881 C  CA   . TYR   B 2 25  ? 6.60935   -7.06850  20.13981 1.000 31.94026  ? 1139 TYR   E CA   1 
ATOM   2882 C  C    . TYR   B 2 25  ? 6.21493   -6.85381  18.68870 1.000 42.51145  ? 1139 TYR   E C    1 
ATOM   2883 O  O    . TYR   B 2 25  ? 6.94597   -6.23645  17.91380 1.000 36.69519  ? 1139 TYR   E O    1 
ATOM   2884 C  CB   . TYR   B 2 25  ? 5.82645   -6.09833  21.04137 1.000 35.53655  ? 1139 TYR   E CB   1 
ATOM   2885 C  CG   . TYR   B 2 25  ? 6.15354   -6.22228  22.51009 1.000 38.73415  ? 1139 TYR   E CG   1 
ATOM   2886 C  CD1  . TYR   B 2 25  ? 7.23276   -5.54409  23.05439 1.000 36.24601  ? 1139 TYR   E CD1  1 
ATOM   2887 C  CD2  . TYR   B 2 25  ? 5.39967   -7.01492  23.34398 1.000 36.98874  ? 1139 TYR   E CD2  1 
ATOM   2888 C  CE1  . TYR   B 2 25  ? 7.55350   -5.66105  24.36292 1.000 32.32457  ? 1139 TYR   E CE1  1 
ATOM   2889 C  CE2  . TYR   B 2 25  ? 5.70470   -7.12069  24.66724 1.000 45.09858  ? 1139 TYR   E CE2  1 
ATOM   2890 C  CZ   . TYR   B 2 25  ? 6.80037   -6.44124  25.16798 1.000 39.41550  ? 1139 TYR   E CZ   1 
ATOM   2891 O  OH   . TYR   B 2 25  ? 7.13664   -6.52476  26.48445 1.000 42.57798  ? 1139 TYR   E OH   1 
ATOM   2892 H  H    . TYR   B 2 25  ? 8.39087   -6.23584  19.92124 1.000 42.81861  ? 1139 TYR   E H    1 
ATOM   2893 H  HA   . TYR   B 2 25  ? 6.36203   -7.97233  20.39046 1.000 38.34358  ? 1139 TYR   E HA   1 
ATOM   2894 H  HB2  . TYR   B 2 25  ? 6.02963   -5.18954  20.76988 1.000 42.65914  ? 1139 TYR   E HB2  1 
ATOM   2895 H  HB3  . TYR   B 2 25  ? 4.87811   -6.27220  20.93496 1.000 42.65914  ? 1139 TYR   E HB3  1 
ATOM   2896 H  HD1  . TYR   B 2 25  ? 7.74801   -4.99620  22.50737 1.000 43.51048  ? 1139 TYR   E HD1  1 
ATOM   2897 H  HD2  . TYR   B 2 25  ? 4.67368   -7.48380  23.00050 1.000 44.40177  ? 1139 TYR   E HD2  1 
ATOM   2898 H  HE1  . TYR   B 2 25  ? 8.28863   -5.20673  24.70654 1.000 38.80476  ? 1139 TYR   E HE1  1 
ATOM   2899 H  HE2  . TYR   B 2 25  ? 5.18091   -7.64507  25.22900 1.000 54.13357  ? 1139 TYR   E HE2  1 
ATOM   2900 H  HH   . TYR   B 2 25  ? 7.71487   -5.94461  26.67063 1.000 51.10885  ? 1139 TYR   E HH   1 
ATOM   2901 N  N    . VAL   B 2 26  ? 5.05098   -7.39798  18.31782 1.000 44.24380  ? 1140 VAL   E N    1 
ATOM   2902 C  CA   . VAL   B 2 26  ? 4.51724   -7.27076  16.96403 1.000 40.50491  ? 1140 VAL   E CA   1 
ATOM   2903 C  C    . VAL   B 2 26  ? 3.03701   -6.94426  17.04293 1.000 41.35865  ? 1140 VAL   E C    1 
ATOM   2904 O  O    . VAL   B 2 26  ? 2.29217   -7.57356  17.80357 1.000 34.82689  ? 1140 VAL   E O    1 
ATOM   2905 C  CB   . VAL   B 2 26  ? 4.73804   -8.54660  16.13570 1.000 42.64426  ? 1140 VAL   E CB   1 
ATOM   2906 C  CG1  . VAL   B 2 26  ? 4.34448   -8.32018  14.69555 1.000 42.48641  ? 1140 VAL   E CG1  1 
ATOM   2907 C  CG2  . VAL   B 2 26  ? 6.16973   -8.95191  16.20635 1.000 49.42954  ? 1140 VAL   E CG2  1 
ATOM   2908 H  H    . VAL   B 2 26  ? 4.54597   -7.85297  18.84466 1.000 53.10784  ? 1140 VAL   E H    1 
ATOM   2909 H  HA   . VAL   B 2 26  ? 4.96530   -6.53292  16.52161 1.000 48.62116  ? 1140 VAL   E HA   1 
ATOM   2910 H  HB   . VAL   B 2 26  ? 4.18498   -9.25658  16.49759 1.000 51.18839  ? 1140 VAL   E HB   1 
ATOM   2911 H  HG11 . VAL   B 2 26  ? 4.55151   -9.11698  14.18257 1.000 50.99896  ? 1140 VAL   E HG11 1 
ATOM   2912 H  HG12 . VAL   B 2 26  ? 3.39277   -8.13752  14.65322 1.000 50.99896  ? 1140 VAL   E HG12 1 
ATOM   2913 H  HG13 . VAL   B 2 26  ? 4.84224   -7.56397  14.34730 1.000 50.99896  ? 1140 VAL   E HG13 1 
ATOM   2914 H  HG21 . VAL   B 2 26  ? 6.33010   -9.65851  15.56145 1.000 59.33072  ? 1140 VAL   E HG21 1 
ATOM   2915 H  HG22 . VAL   B 2 26  ? 6.72580   -8.18413  16.00093 1.000 59.33072  ? 1140 VAL   E HG22 1 
ATOM   2916 H  HG23 . VAL   B 2 26  ? 6.36383   -9.27087  17.10161 1.000 59.33072  ? 1140 VAL   E HG23 1 
ATOM   2917 N  N    . ILE   B 2 27  ? 2.61596   -5.96679  16.25781 1.000 36.08910  ? 1141 ILE   E N    1 
ATOM   2918 C  CA   . ILE   B 2 27  ? 1.21004   -5.64919  16.09189 1.000 41.89918  ? 1141 ILE   E CA   1 
ATOM   2919 C  C    . ILE   B 2 27  ? 0.87614   -5.83307  14.62353 1.000 43.19533  ? 1141 ILE   E C    1 
ATOM   2920 O  O    . ILE   B 2 27  ? 1.75108   -5.75418  13.75567 1.000 41.74844  ? 1141 ILE   E O    1 
ATOM   2921 C  CB   . ILE   B 2 27  ? 0.88024   -4.22359  16.57591 1.000 38.70702  ? 1141 ILE   E CB   1 
ATOM   2922 C  CG1  . ILE   B 2 27  ? 1.74277   -3.17131  15.88029 1.000 32.23610  ? 1141 ILE   E CG1  1 
ATOM   2923 C  CG2  . ILE   B 2 27  ? 1.07595   -4.16186  18.05099 1.000 42.85169  ? 1141 ILE   E CG2  1 
ATOM   2924 C  CD1  . ILE   B 2 27  ? 1.42838   -1.74738  16.34628 1.000 37.62069  ? 1141 ILE   E CD1  1 
ATOM   2925 H  H    . ILE   B 2 27  ? 3.13932   -5.46111  15.79956 1.000 43.32220  ? 1141 ILE   E H    1 
ATOM   2926 H  HA   . ILE   B 2 27  ? 0.66324   -6.25841  16.61223 1.000 50.29430  ? 1141 ILE   E HA   1 
ATOM   2927 H  HB   . ILE   B 2 27  ? -0.04250  -4.02816  16.34951 1.000 46.46370  ? 1141 ILE   E HB   1 
ATOM   2928 H  HG12 . ILE   B 2 27  ? 2.67647   -3.35103  16.07213 1.000 38.69859  ? 1141 ILE   E HG12 1 
ATOM   2929 H  HG13 . ILE   B 2 27  ? 1.58596   -3.21609  14.92409 1.000 38.69859  ? 1141 ILE   E HG13 1 
ATOM   2930 H  HG21 . ILE   B 2 27  ? 0.69666   -3.33413  18.38551 1.000 51.43731  ? 1141 ILE   E HG21 1 
ATOM   2931 H  HG22 . ILE   B 2 27  ? 0.62985   -4.91950  18.46072 1.000 51.43731  ? 1141 ILE   E HG22 1 
ATOM   2932 H  HG23 . ILE   B 2 27  ? 2.02583   -4.19269  18.24509 1.000 51.43731  ? 1141 ILE   E HG23 1 
ATOM   2933 H  HD11 . ILE   B 2 27  ? 1.90816   -1.11828  15.78507 1.000 45.16011  ? 1141 ILE   E HD11 1 
ATOM   2934 H  HD12 . ILE   B 2 27  ? 0.47331   -1.59465  16.27271 1.000 45.16011  ? 1141 ILE   E HD12 1 
ATOM   2935 H  HD13 . ILE   B 2 27  ? 1.70912   -1.64798  17.26943 1.000 45.16011  ? 1141 ILE   E HD13 1 
ATOM   2936 N  N    . TYR   B 2 28  ? -0.39692  -6.10218  14.35050 1.000 44.25750  ? 1142 TYR   E N    1 
ATOM   2937 C  CA   . TYR   B 2 28  ? -0.86687  -6.35582  12.99544 1.000 48.03697  ? 1142 TYR   E CA   1 
ATOM   2938 C  C    . TYR   B 2 28  ? -1.83817  -5.30309  12.49188 1.000 50.04163  ? 1142 TYR   E C    1 
ATOM   2939 O  O    . TYR   B 2 28  ? -2.36212  -5.45057  11.38727 1.000 54.90288  ? 1142 TYR   E O    1 
ATOM   2940 C  CB   . TYR   B 2 28  ? -1.49378  -7.75796  12.94139 1.000 53.72262  ? 1142 TYR   E CB   1 
ATOM   2941 C  CG   . TYR   B 2 28  ? -0.50161  -8.75385  13.45141 1.000 47.79133  ? 1142 TYR   E CG   1 
ATOM   2942 C  CD1  . TYR   B 2 28  ? 0.47773   -9.26265  12.61429 1.000 50.33040  ? 1142 TYR   E CD1  1 
ATOM   2943 C  CD2  . TYR   B 2 28  ? -0.49281  -9.12545  14.78112 1.000 49.01296  ? 1142 TYR   E CD2  1 
ATOM   2944 C  CE1  . TYR   B 2 28  ? 1.41761   -10.12634 13.07637 1.000 55.75878  ? 1142 TYR   E CE1  1 
ATOM   2945 C  CE2  . TYR   B 2 28  ? 0.44418   -10.00979 15.26010 1.000 53.01209  ? 1142 TYR   E CE2  1 
ATOM   2946 C  CZ   . TYR   B 2 28  ? 1.39975   -10.49802 14.40325 1.000 57.64956  ? 1142 TYR   E CZ   1 
ATOM   2947 O  OH   . TYR   B 2 28  ? 2.33973   -11.37774 14.85698 1.000 59.56415  ? 1142 TYR   E OH   1 
ATOM   2948 H  H    . TYR   B 2 28  ? -1.01721  -6.14385  14.94472 1.000 53.12428  ? 1142 TYR   E H    1 
ATOM   2949 H  HA   . TYR   B 2 28  ? -0.11615  -6.34274  12.38131 1.000 57.65964  ? 1142 TYR   E HA   1 
ATOM   2950 H  HB2  . TYR   B 2 28  ? -2.28648  -7.78699  13.49968 1.000 64.48242  ? 1142 TYR   E HB2  1 
ATOM   2951 H  HB3  . TYR   B 2 28  ? -1.72428  -7.98155  12.02609 1.000 64.48242  ? 1142 TYR   E HB3  1 
ATOM   2952 H  HD1  . TYR   B 2 28  ? 0.49161   -9.00806  11.71993 1.000 60.41176  ? 1142 TYR   E HD1  1 
ATOM   2953 H  HD2  . TYR   B 2 28  ? -1.12922  -8.77278  15.36035 1.000 58.83083  ? 1142 TYR   E HD2  1 
ATOM   2954 H  HE1  . TYR   B 2 28  ? 2.06731   -10.46397 12.50297 1.000 66.92582  ? 1142 TYR   E HE1  1 
ATOM   2955 H  HE2  . TYR   B 2 28  ? 0.43114   -10.27371 16.15178 1.000 63.62978  ? 1142 TYR   E HE2  1 
ATOM   2956 H  HH   . TYR   B 2 28  ? 2.86466   -11.58376 14.23440 1.000 71.49226  ? 1142 TYR   E HH   1 
ATOM   2957 N  N    . ARG   B 2 29  ? -2.08278  -4.25219  13.27107 1.000 46.56894  ? 1143 ARG   E N    1 
ATOM   2958 C  CA   . ARG   B 2 29  ? -2.86839  -3.09703  12.86685 1.000 44.53022  ? 1143 ARG   E CA   1 
ATOM   2959 C  C    . ARG   B 2 29  ? -2.01663  -1.87348  13.16697 1.000 45.07818  ? 1143 ARG   E C    1 
ATOM   2960 O  O    . ARG   B 2 29  ? -1.59961  -1.69005  14.31268 1.000 42.51303  ? 1143 ARG   E O    1 
ATOM   2961 C  CB   . ARG   B 2 29  ? -4.18476  -3.00449  13.63722 1.000 51.84598  ? 1143 ARG   E CB   1 
ATOM   2962 C  CG   . ARG   B 2 29  ? -4.97257  -4.28803  13.76591 1.000 57.00965  ? 1143 ARG   E CG   1 
ATOM   2963 C  CD   . ARG   B 2 29  ? -6.11291  -4.31323  12.79751 1.000 53.39602  ? 1143 ARG   E CD   1 
ATOM   2964 N  NE   . ARG   B 2 29  ? -6.97640  -3.14834  12.93562 1.000 62.23314  ? 1143 ARG   E NE   1 
ATOM   2965 C  CZ   . ARG   B 2 29  ? -8.20850  -3.16664  13.42505 1.000 55.63858  ? 1143 ARG   E CZ   1 
ATOM   2966 N  NH1  . ARG   B 2 29  ? -8.75233  -4.28037  13.91105 1.000 58.06858  ? 1143 ARG   E NH1  1 
ATOM   2967 N  NH2  . ARG   B 2 29  ? -8.91612  -2.04368  13.41303 1.000 57.68976  ? 1143 ARG   E NH2  1 
ATOM   2968 H  H    . ARG   B 2 29  ? -1.78868  -4.18511  14.07643 1.000 55.89800  ? 1143 ARG   E H    1 
ATOM   2969 H  HA   . ARG   B 2 29  ? -3.07979  -3.15027  11.92166 1.000 53.45154  ? 1143 ARG   E HA   1 
ATOM   2970 H  HB2  . ARG   B 2 29  ? -3.98819  -2.69829  14.53639 1.000 62.23045  ? 1143 ARG   E HB2  1 
ATOM   2971 H  HB3  . ARG   B 2 29  ? -4.75516  -2.36297  13.18556 1.000 62.23045  ? 1143 ARG   E HB3  1 
ATOM   2972 H  HG2  . ARG   B 2 29  ? -4.39350  -5.04337  13.57873 1.000 68.42686  ? 1143 ARG   E HG2  1 
ATOM   2973 H  HG3  . ARG   B 2 29  ? -5.33072  -4.35926  14.66455 1.000 68.42686  ? 1143 ARG   E HG3  1 
ATOM   2974 H  HD2  . ARG   B 2 29  ? -5.76263  -4.32438  11.89303 1.000 64.09050  ? 1143 ARG   E HD2  1 
ATOM   2975 H  HD3  . ARG   B 2 29  ? -6.64795  -5.10666  12.95588 1.000 64.09050  ? 1143 ARG   E HD3  1 
ATOM   2976 H  HE   . ARG   B 2 29  ? -6.66261  -2.38960  12.67979 1.000 74.69504  ? 1143 ARG   E HE   1 
ATOM   2977 H  HH11 . ARG   B 2 29  ? -8.30239  -5.01327  13.91291 1.000 69.69757  ? 1143 ARG   E HH11 1 
ATOM   2978 H  HH12 . ARG   B 2 29  ? -9.55359  -4.26693  14.22315 1.000 69.69757  ? 1143 ARG   E HH12 1 
ATOM   2979 H  HH21 . ARG   B 2 29  ? -8.57370  -1.32307  13.09198 1.000 69.24299  ? 1143 ARG   E HH21 1 
ATOM   2980 H  HH22 . ARG   B 2 29  ? -9.71700  -2.03672  13.72630 1.000 69.24299  ? 1143 ARG   E HH22 1 
ATOM   2981 N  N    . GLY   B 2 30  ? -1.75348  -1.04549  12.15696 1.000 49.40782  ? 1144 GLY   E N    1 
ATOM   2982 C  CA   . GLY   B 2 30  ? -0.94484  0.13942   12.37882 1.000 49.67751  ? 1144 GLY   E CA   1 
ATOM   2983 C  C    . GLY   B 2 30  ? -1.59956  1.14437   13.30082 1.000 50.87960  ? 1144 GLY   E C    1 
ATOM   2984 O  O    . GLY   B 2 30  ? -0.89923  1.95204   13.91550 1.000 46.63658  ? 1144 GLY   E O    1 
ATOM   2985 H  H    . GLY   B 2 30  ? -2.02877  -1.14944  11.34887 1.000 59.30466  ? 1144 GLY   E H    1 
ATOM   2986 H  HA2  . GLY   B 2 30  ? -0.09741  -0.12356  12.77076 1.000 59.62829  ? 1144 GLY   E HA2  1 
ATOM   2987 H  HA3  . GLY   B 2 30  ? -0.77790  0.57360   11.52764 1.000 59.62829  ? 1144 GLY   E HA3  1 
ATOM   2988 N  N    . GLU   B 2 31  ? -2.93122  1.09789   13.41168 1.000 46.14726  ? 1145 GLU   E N    1 
ATOM   2989 C  CA   . GLU   B 2 31  ? -3.68510  1.91242   14.35286 1.000 46.86804  ? 1145 GLU   E CA   1 
ATOM   2990 C  C    . GLU   B 2 31  ? -3.37897  1.59567   15.80818 1.000 43.61544  ? 1145 GLU   E C    1 
ATOM   2991 O  O    . GLU   B 2 31  ? -3.89171  2.30703   16.67365 1.000 43.04954  ? 1145 GLU   E O    1 
ATOM   2992 C  CB   . GLU   B 2 31  ? -5.20635  1.73022   14.16345 1.000 48.31462  ? 1145 GLU   E CB   1 
ATOM   2993 C  CG   . GLU   B 2 31  ? -5.73391  1.84936   12.75259 1.000 58.90418  ? 1145 GLU   E CG   1 
ATOM   2994 C  CD   . GLU   B 2 31  ? -5.88921  0.51061   12.08370 1.000 58.26482  ? 1145 GLU   E CD   1 
ATOM   2995 O  OE1  . GLU   B 2 31  ? -4.94616  -0.27770  12.17338 1.000 53.16268  ? 1145 GLU   E OE1  1 
ATOM   2996 O  OE2  . GLU   B 2 31  ? -6.94330  0.24121   11.47614 1.000 64.94514  ? 1145 GLU   E OE2  1 
ATOM   2997 H  H    . GLU   B 2 31  ? -3.43227  0.58546   12.93632 1.000 55.39199  ? 1145 GLU   E H    1 
ATOM   2998 H  HA   . GLU   B 2 31  ? -3.44722  2.83321   14.16195 1.000 56.25692  ? 1145 GLU   E HA   1 
ATOM   2999 H  HB2  . GLU   B 2 31  ? -5.44474  0.84539   14.48148 1.000 57.99282  ? 1145 GLU   E HB2  1 
ATOM   3000 H  HB3  . GLU   B 2 31  ? -5.65797  2.40591   14.69297 1.000 57.99282  ? 1145 GLU   E HB3  1 
ATOM   3001 H  HG2  . GLU   B 2 31  ? -6.60361  2.27836   12.77400 1.000 70.70030  ? 1145 GLU   E HG2  1 
ATOM   3002 H  HG3  . GLU   B 2 31  ? -5.11535  2.37949   12.22604 1.000 70.70030  ? 1145 GLU   E HG3  1 
ATOM   3003 N  N    . GLN   B 2 32  ? -2.60678  0.53220   16.10940 1.000 35.29017  ? 1146 GLN   E N    1 
ATOM   3004 C  CA   . GLN   B 2 32  ? -2.24204  0.20017   17.48985 1.000 32.35905  ? 1146 GLN   E CA   1 
ATOM   3005 C  C    . GLN   B 2 32  ? -0.91947  0.81631   17.93767 1.000 32.66310  ? 1146 GLN   E C    1 
ATOM   3006 O  O    . GLN   B 2 32  ? -0.46898  0.53579   19.04306 1.000 40.88490  ? 1146 GLN   E O    1 
ATOM   3007 C  CB   . GLN   B 2 32  ? -2.19770  -1.32625  17.68560 1.000 37.96773  ? 1146 GLN   E CB   1 
ATOM   3008 C  CG   . GLN   B 2 32  ? -3.59255  -1.90102  17.97139 1.000 36.82733  ? 1146 GLN   E CG   1 
ATOM   3009 C  CD   . GLN   B 2 32  ? -3.66566  -3.40984  18.00314 1.000 41.58467  ? 1146 GLN   E CD   1 
ATOM   3010 O  OE1  . GLN   B 2 32  ? -4.55339  -4.02423  17.37987 1.000 47.55072  ? 1146 GLN   E OE1  1 
ATOM   3011 N  NE2  . GLN   B 2 32  ? -2.74617  -4.02575  18.73766 1.000 40.94447  ? 1146 GLN   E NE2  1 
ATOM   3012 H  H    . GLN   B 2 32  ? -2.28426  -0.00972  15.52467 1.000 42.36348  ? 1146 GLN   E H    1 
ATOM   3013 H  HA   . GLN   B 2 32  ? -2.93605  0.55429   18.06764 1.000 38.84614  ? 1146 GLN   E HA   1 
ATOM   3014 H  HB2  . GLN   B 2 32  ? -1.85555  -1.74248  16.87901 1.000 45.57656  ? 1146 GLN   E HB2  1 
ATOM   3015 H  HB3  . GLN   B 2 32  ? -1.62144  -1.53585  18.43719 1.000 45.57656  ? 1146 GLN   E HB3  1 
ATOM   3016 H  HG2  . GLN   B 2 32  ? -3.88716  -1.57753  18.83710 1.000 44.20807  ? 1146 GLN   E HG2  1 
ATOM   3017 H  HG3  . GLN   B 2 32  ? -4.19912  -1.59520  17.27897 1.000 44.20807  ? 1146 GLN   E HG3  1 
ATOM   3018 H  HE21 . GLN   B 2 32  ? -2.15490  -3.56615  19.16047 1.000 49.14864  ? 1146 GLN   E HE21 1 
ATOM   3019 H  HE22 . GLN   B 2 32  ? -2.74211  -4.88412  18.79042 1.000 49.14864  ? 1146 GLN   E HE22 1 
ATOM   3020 N  N    . ALA   B 2 33  ? -0.32493  1.69300   17.14129 1.000 37.72006  ? 1147 ALA   E N    1 
ATOM   3021 C  CA   . ALA   B 2 33  ? 0.86064   2.41727   17.54648 1.000 38.15223  ? 1147 ALA   E CA   1 
ATOM   3022 C  C    . ALA   B 2 33  ? 0.73798   3.87662   17.12535 1.000 39.17465  ? 1147 ALA   E C    1 
ATOM   3023 O  O    . ALA   B 2 33  ? 0.15969   4.19865   16.09338 1.000 35.22488  ? 1147 ALA   E O    1 
ATOM   3024 C  CB   . ALA   B 2 33  ? 2.11189   1.77801   16.93345 1.000 37.17047  ? 1147 ALA   E CB   1 
ATOM   3025 H  H    . ALA   B 2 33  ? -0.59683  1.88634   16.34864 1.000 45.27935  ? 1147 ALA   E H    1 
ATOM   3026 H  HA   . ALA   B 2 33  ? 0.94937   2.40781   18.51237 1.000 45.79796  ? 1147 ALA   E HA   1 
ATOM   3027 H  HB1  . ALA   B 2 33  ? 2.89370   2.27463   17.22161 1.000 44.61984  ? 1147 ALA   E HB1  1 
ATOM   3028 H  HB2  . ALA   B 2 33  ? 2.17554   0.85772   17.23330 1.000 44.61984  ? 1147 ALA   E HB2  1 
ATOM   3029 H  HB3  . ALA   B 2 33  ? 2.03970   1.80662   15.96656 1.000 44.61984  ? 1147 ALA   E HB3  1 
ATOM   3030 N  N    . TYR   B 2 34  ? 1.31740   4.75715   17.92800 1.000 35.62479  ? 1148 TYR   E N    1 
ATOM   3031 C  CA   . TYR   B 2 34  ? 1.38806   6.15820   17.56149 1.000 46.44449  ? 1148 TYR   E CA   1 
ATOM   3032 C  C    . TYR   B 2 34  ? 2.84289   6.63167   17.74299 1.000 41.18801  ? 1148 TYR   E C    1 
ATOM   3033 O  O    . TYR   B 2 34  ? 3.42208   6.41543   18.81024 1.000 36.15758  ? 1148 TYR   E O    1 
ATOM   3034 C  CB   . TYR   B 2 34  ? 0.44228   6.99390   18.42834 1.000 42.01322  ? 1148 TYR   E CB   1 
ATOM   3035 C  CG   . TYR   B 2 34  ? 0.50727   8.46153   18.13213 1.000 48.89455  ? 1148 TYR   E CG   1 
ATOM   3036 C  CD1  . TYR   B 2 34  ? 1.43519   9.25983   18.76379 1.000 47.77451  ? 1148 TYR   E CD1  1 
ATOM   3037 C  CD2  . TYR   B 2 34  ? -0.37428  9.05022   17.22374 1.000 39.98883  ? 1148 TYR   E CD2  1 
ATOM   3038 C  CE1  . TYR   B 2 34  ? 1.50630   10.60524  18.48755 1.000 46.75781  ? 1148 TYR   E CE1  1 
ATOM   3039 C  CE2  . TYR   B 2 34  ? -0.31364  10.36117  16.94549 1.000 42.86094  ? 1148 TYR   E CE2  1 
ATOM   3040 C  CZ   . TYR   B 2 34  ? 0.64061   11.15027  17.57575 1.000 50.78847  ? 1148 TYR   E CZ   1 
ATOM   3041 O  OH   . TYR   B 2 34  ? 0.71813   12.49701  17.30985 1.000 53.25609  ? 1148 TYR   E OH   1 
ATOM   3042 H  H    . TYR   B 2 34  ? 1.67469   4.56580   18.68651 1.000 42.76502  ? 1148 TYR   E H    1 
ATOM   3043 H  HA   . TYR   B 2 34  ? 1.13184   6.27121   16.63279 1.000 55.74867  ? 1148 TYR   E HA   1 
ATOM   3044 H  HB2  . TYR   B 2 34  ? -0.46855  6.69864   18.27305 1.000 50.43114  ? 1148 TYR   E HB2  1 
ATOM   3045 H  HB3  . TYR   B 2 34  ? 0.67760   6.86743   19.36083 1.000 50.43114  ? 1148 TYR   E HB3  1 
ATOM   3046 H  HD1  . TYR   B 2 34  ? 2.01930   8.88540   19.38308 1.000 57.34469  ? 1148 TYR   E HD1  1 
ATOM   3047 H  HD2  . TYR   B 2 34  ? -1.01557  8.52375   16.80363 1.000 48.00188  ? 1148 TYR   E HD2  1 
ATOM   3048 H  HE1  . TYR   B 2 34  ? 2.13567   11.13984  18.91532 1.000 56.12465  ? 1148 TYR   E HE1  1 
ATOM   3049 H  HE2  . TYR   B 2 34  ? -0.90558  10.73877  16.33564 1.000 51.44841  ? 1148 TYR   E HE2  1 
ATOM   3050 H  HH   . TYR   B 2 34  ? 1.43722   12.80862  17.61219 1.000 63.92258  ? 1148 TYR   E HH   1 
ATOM   3051 N  N    . PRO   B 2 35  ? 3.42021   7.27511   16.76246 1.000 43.37155  ? 1149 PRO   E N    1 
ATOM   3052 C  CA   . PRO   B 2 35  ? 4.83843   7.63851   16.90233 1.000 43.81503  ? 1149 PRO   E CA   1 
ATOM   3053 C  C    . PRO   B 2 35  ? 5.03318   8.90420   17.71837 1.000 43.38497  ? 1149 PRO   E C    1 
ATOM   3054 O  O    . PRO   B 2 35  ? 4.91017   9.98872   17.15944 1.000 58.19085  ? 1149 PRO   E O    1 
ATOM   3055 C  CB   . PRO   B 2 35  ? 5.26294   7.83476   15.44209 1.000 40.18289  ? 1149 PRO   E CB   1 
ATOM   3056 C  CG   . PRO   B 2 35  ? 4.08626   8.31488   14.79459 1.000 51.95623  ? 1149 PRO   E CG   1 
ATOM   3057 C  CD   . PRO   B 2 35  ? 2.91212   7.62291   15.43210 1.000 41.50083  ? 1149 PRO   E CD   1 
ATOM   3058 H  HA   . PRO   B 2 35  ? 5.34969   6.91967   17.30578 1.000 52.59332  ? 1149 PRO   E HA   1 
ATOM   3059 H  HB2  . PRO   B 2 35  ? 5.98130   8.48438   15.38860 1.000 48.23474  ? 1149 PRO   E HB2  1 
ATOM   3060 H  HB3  . PRO   B 2 35  ? 5.55084   6.98977   15.06260 1.000 48.23474  ? 1149 PRO   E HB3  1 
ATOM   3061 H  HG2  . PRO   B 2 35  ? 4.02079   9.27484   14.91739 1.000 62.36275  ? 1149 PRO   E HG2  1 
ATOM   3062 H  HG3  . PRO   B 2 35  ? 4.13088   8.10367   13.84891 1.000 62.36275  ? 1149 PRO   E HG3  1 
ATOM   3063 H  HD2  . PRO   B 2 35  ? 2.15082   8.22050   15.49700 1.000 49.81628  ? 1149 PRO   E HD2  1 
ATOM   3064 H  HD3  . PRO   B 2 35  ? 2.66736   6.82655   14.93530 1.000 49.81628  ? 1149 PRO   E HD3  1 
ATOM   3065 N  N    . GLU   B 2 36  ? 5.33699   8.80000   19.01797 1.000 36.35469  ? 1150 GLU   E N    1 
ATOM   3066 C  CA   . GLU   B 2 36  ? 5.25308   9.96010   19.90932 1.000 39.47909  ? 1150 GLU   E CA   1 
ATOM   3067 C  C    . GLU   B 2 36  ? 6.47822   10.85238  19.85607 1.000 40.46846  ? 1150 GLU   E C    1 
ATOM   3068 O  O    . GLU   B 2 36  ? 6.35380   12.06001  20.04932 1.000 38.26171  ? 1150 GLU   E O    1 
ATOM   3069 C  CB   . GLU   B 2 36  ? 5.09130   9.54895   21.37258 1.000 42.57903  ? 1150 GLU   E CB   1 
ATOM   3070 C  CG   . GLU   B 2 36  ? 3.74191   9.00176   21.75431 1.000 54.71265  ? 1150 GLU   E CG   1 
ATOM   3071 C  CD   . GLU   B 2 36  ? 3.01105   9.87673   22.73475 1.000 55.03461  ? 1150 GLU   E CD   1 
ATOM   3072 O  OE1  . GLU   B 2 36  ? 3.50061   10.97027  23.03361 1.000 59.20397  ? 1150 GLU   E OE1  1 
ATOM   3073 O  OE2  . GLU   B 2 36  ? 1.93056   9.47411   23.19500 1.000 62.33932  ? 1150 GLU   E OE2  1 
ATOM   3074 H  H    . GLU   B 2 36  ? 5.59196   8.07515   19.40419 1.000 43.64090  ? 1150 GLU   E H    1 
ATOM   3075 H  HA   . GLU   B 2 36  ? 4.46932   10.44495  19.60679 1.000 47.39018  ? 1150 GLU   E HA   1 
ATOM   3076 H  HB2  . GLU   B 2 36  ? 5.74636   8.86106   21.56906 1.000 51.11011  ? 1150 GLU   E HB2  1 
ATOM   3077 H  HB3  . GLU   B 2 36  ? 5.25248   10.32855  21.92679 1.000 51.11011  ? 1150 GLU   E HB3  1 
ATOM   3078 H  HG2  . GLU   B 2 36  ? 3.19546   8.92499   20.95656 1.000 65.67046  ? 1150 GLU   E HG2  1 
ATOM   3079 H  HG3  . GLU   B 2 36  ? 3.85903   8.12916   22.16145 1.000 65.67046  ? 1150 GLU   E HG3  1 
ATOM   3080 N  N    . TYR   B 2 37  ? 7.66858   10.26795  19.71967 1.000 36.28158  ? 1151 TYR   E N    1 
ATOM   3081 C  CA   . TYR   B 2 37  ? 8.92516   11.00631  19.78659 1.000 37.96455  ? 1151 TYR   E CA   1 
ATOM   3082 C  C    . TYR   B 2 37  ? 9.81340   10.56510  18.64335 1.000 39.78689  ? 1151 TYR   E C    1 
ATOM   3083 O  O    . TYR   B 2 37  ? 9.89994   9.37228   18.32962 1.000 39.59144  ? 1151 TYR   E O    1 
ATOM   3084 C  CB   . TYR   B 2 37  ? 9.66184   10.79644  21.10172 1.000 38.39367  ? 1151 TYR   E CB   1 
ATOM   3085 C  CG   . TYR   B 2 37  ? 8.88983   11.27613  22.30238 1.000 44.14665  ? 1151 TYR   E CG   1 
ATOM   3086 C  CD1  . TYR   B 2 37  ? 9.00740   12.57939  22.76060 1.000 41.78453  ? 1151 TYR   E CD1  1 
ATOM   3087 C  CD2  . TYR   B 2 37  ? 8.04519   10.42394  22.98689 1.000 46.25869  ? 1151 TYR   E CD2  1 
ATOM   3088 C  CE1  . TYR   B 2 37  ? 8.30699   13.00138  23.87283 1.000 40.76821  ? 1151 TYR   E CE1  1 
ATOM   3089 C  CE2  . TYR   B 2 37  ? 7.33560   10.83999  24.08641 1.000 43.47367  ? 1151 TYR   E CE2  1 
ATOM   3090 C  CZ   . TYR   B 2 37  ? 7.46199   12.12819  24.52374 1.000 47.07622  ? 1151 TYR   E CZ   1 
ATOM   3091 O  OH   . TYR   B 2 37  ? 6.73497   12.52683  25.63091 1.000 43.49191  ? 1151 TYR   E OH   1 
ATOM   3092 H  H    . TYR   B 2 37  ? 7.77423   9.42523   19.58448 1.000 43.55318  ? 1151 TYR   E H    1 
ATOM   3093 H  HA   . TYR   B 2 37  ? 8.73459   11.95403  19.70654 1.000 45.57273  ? 1151 TYR   E HA   1 
ATOM   3094 H  HB2  . TYR   B 2 37  ? 9.83305   9.84867   21.21713 1.000 46.08768  ? 1151 TYR   E HB2  1 
ATOM   3095 H  HB3  . TYR   B 2 37  ? 10.49999  11.28384  21.07257 1.000 46.08768  ? 1151 TYR   E HB3  1 
ATOM   3096 H  HD1  . TYR   B 2 37  ? 9.56404   13.17564  22.31391 1.000 50.15671  ? 1151 TYR   E HD1  1 
ATOM   3097 H  HD2  . TYR   B 2 37  ? 7.95477   9.54544   22.69542 1.000 55.52570  ? 1151 TYR   E HD2  1 
ATOM   3098 H  HE1  . TYR   B 2 37  ? 8.40501   13.87288  24.18230 1.000 48.93712  ? 1151 TYR   E HE1  1 
ATOM   3099 H  HE2  . TYR   B 2 37  ? 6.77224   10.24835  24.53081 1.000 52.18369  ? 1151 TYR   E HE2  1 
ATOM   3100 H  HH   . TYR   B 2 37  ? 6.75713   13.36343  25.70317 1.000 52.20557  ? 1151 TYR   E HH   1 
ATOM   3101 N  N    . LEU   B 2 38  ? 10.44359  11.54058  18.00940 1.000 39.82191  ? 1152 LEU   E N    1 
ATOM   3102 C  CA   . LEU   B 2 38  ? 11.40198  11.31926  16.94231 1.000 37.67153  ? 1152 LEU   E CA   1 
ATOM   3103 C  C    . LEU   B 2 38  ? 12.74800  11.70925  17.51904 1.000 44.87986  ? 1152 LEU   E C    1 
ATOM   3104 O  O    . LEU   B 2 38  ? 12.92340  12.86268  17.92299 1.000 36.88088  ? 1152 LEU   E O    1 
ATOM   3105 C  CB   . LEU   B 2 38  ? 11.04881  12.16168  15.72496 1.000 41.24725  ? 1152 LEU   E CB   1 
ATOM   3106 C  CG   . LEU   B 2 38  ? 12.02180  12.04851  14.55595 1.000 40.55806  ? 1152 LEU   E CG   1 
ATOM   3107 C  CD1  . LEU   B 2 38  ? 11.94915  10.65606  13.94937 1.000 39.41964  ? 1152 LEU   E CD1  1 
ATOM   3108 C  CD2  . LEU   B 2 38  ? 11.71762  13.11590  13.54972 1.000 29.96017  ? 1152 LEU   E CD2  1 
ATOM   3109 H  H    . LEU   B 2 38  ? 10.32699  12.37373  18.18791 1.000 47.80157  ? 1152 LEU   E H    1 
ATOM   3110 H  HA   . LEU   B 2 38  ? 11.42207  10.39417  16.65128 1.000 45.22111  ? 1152 LEU   E HA   1 
ATOM   3111 H  HB2  . LEU   B 2 38  ? 10.17572  11.88580  15.40480 1.000 49.51198  ? 1152 LEU   E HB2  1 
ATOM   3112 H  HB3  . LEU   B 2 38  ? 11.02430  13.09325  15.99419 1.000 49.51198  ? 1152 LEU   E HB3  1 
ATOM   3113 H  HG   . LEU   B 2 38  ? 12.93427  12.17925  14.85794 1.000 48.68494  ? 1152 LEU   E HG   1 
ATOM   3114 H  HD11 . LEU   B 2 38  ? 12.54792  10.61184  13.18752 1.000 47.31884  ? 1152 LEU   E HD11 1 
ATOM   3115 H  HD12 . LEU   B 2 38  ? 12.21604  10.00600  14.61802 1.000 47.31884  ? 1152 LEU   E HD12 1 
ATOM   3116 H  HD13 . LEU   B 2 38  ? 11.03822  10.48277  13.66463 1.000 47.31884  ? 1152 LEU   E HD13 1 
ATOM   3117 H  HD21 . LEU   B 2 38  ? 12.34882  13.04766  12.81635 1.000 35.96748  ? 1152 LEU   E HD21 1 
ATOM   3118 H  HD22 . LEU   B 2 38  ? 10.81363  12.99143  13.22077 1.000 35.96748  ? 1152 LEU   E HD22 1 
ATOM   3119 H  HD23 . LEU   B 2 38  ? 11.79806  13.98364  13.97571 1.000 35.96748  ? 1152 LEU   E HD23 1 
ATOM   3120 N  N    . ILE   B 2 39  ? 13.67671  10.75242  17.57640 1.000 34.64562  ? 1153 ILE   E N    1 
ATOM   3121 C  CA   . ILE   B 2 39  ? 14.94306  10.91107  18.27656 1.000 40.56902  ? 1153 ILE   E CA   1 
ATOM   3122 C  C    . ILE   B 2 39  ? 16.04567  10.85181  17.23495 1.000 44.18010  ? 1153 ILE   E C    1 
ATOM   3123 O  O    . ILE   B 2 39  ? 16.17142  9.84431   16.52332 1.000 43.09361  ? 1153 ILE   E O    1 
ATOM   3124 C  CB   . ILE   B 2 39  ? 15.15029  9.82841   19.34807 1.000 37.69503  ? 1153 ILE   E CB   1 
ATOM   3125 C  CG1  . ILE   B 2 39  ? 14.05875  9.88806   20.39545 1.000 40.18342  ? 1153 ILE   E CG1  1 
ATOM   3126 C  CG2  . ILE   B 2 39  ? 16.47444  10.03148  20.04398 1.000 35.77884  ? 1153 ILE   E CG2  1 
ATOM   3127 C  CD1  . ILE   B 2 39  ? 13.89662  8.65277   21.18385 1.000 44.39931  ? 1153 ILE   E CD1  1 
ATOM   3128 H  H    . ILE   B 2 39  ? 13.58877  9.98178   17.20494 1.000 41.59002  ? 1153 ILE   E H    1 
ATOM   3129 H  HA   . ILE   B 2 39  ? 14.96526  11.77710  18.71290 1.000 48.69811  ? 1153 ILE   E HA   1 
ATOM   3130 H  HB   . ILE   B 2 39  ? 15.12799  8.96891   18.89899 1.000 45.24931  ? 1153 ILE   E HB   1 
ATOM   3131 H  HG12 . ILE   B 2 39  ? 14.26438  10.60555  21.01499 1.000 48.23538  ? 1153 ILE   E HG12 1 
ATOM   3132 H  HG13 . ILE   B 2 39  ? 13.21451  10.06470  19.95167 1.000 48.23538  ? 1153 ILE   E HG13 1 
ATOM   3133 H  HG21 . ILE   B 2 39  ? 16.52267  9.43867   20.81024 1.000 42.94989  ? 1153 ILE   E HG21 1 
ATOM   3134 H  HG22 . ILE   B 2 39  ? 17.19176  9.82879   19.42329 1.000 42.94989  ? 1153 ILE   E HG22 1 
ATOM   3135 H  HG23 . ILE   B 2 39  ? 16.53989  10.95443  20.33516 1.000 42.94989  ? 1153 ILE   E HG23 1 
ATOM   3136 H  HD11 . ILE   B 2 39  ? 13.13182  8.75176   21.77223 1.000 53.29445  ? 1153 ILE   E HD11 1 
ATOM   3137 H  HD12 . ILE   B 2 39  ? 13.75416  7.90827   20.57861 1.000 53.29445  ? 1153 ILE   E HD12 1 
ATOM   3138 H  HD13 . ILE   B 2 39  ? 14.69968  8.50453   21.70731 1.000 53.29445  ? 1153 ILE   E HD13 1 
ATOM   3139 N  N    . THR   B 2 40  ? 16.84141  11.91863  17.15749 1.000 39.78374  ? 1154 THR   E N    1 
ATOM   3140 C  CA   . THR   B 2 40  ? 17.98980  12.03535  16.25538 1.000 34.33260  ? 1154 THR   E CA   1 
ATOM   3141 C  C    . THR   B 2 40  ? 19.26329  11.85130  17.06995 1.000 38.51230  ? 1154 THR   E C    1 
ATOM   3142 O  O    . THR   B 2 40  ? 19.41851  12.49399  18.10605 1.000 37.60241  ? 1154 THR   E O    1 
ATOM   3143 C  CB   . THR   B 2 40  ? 17.98375  13.41600  15.57441 1.000 38.31605  ? 1154 THR   E CB   1 
ATOM   3144 O  OG1  . THR   B 2 40  ? 16.75058  13.60588  14.87140 1.000 41.15752  ? 1154 THR   E OG1  1 
ATOM   3145 C  CG2  . THR   B 2 40  ? 19.11684  13.54332  14.58785 1.000 38.04812  ? 1154 THR   E CG2  1 
ATOM   3146 H  H    . THR   B 2 40  ? 16.73183  12.62181  17.64032 1.000 47.75576  ? 1154 THR   E H    1 
ATOM   3147 H  HA   . THR   B 2 40  ? 17.95882  11.35292  15.56673 1.000 41.21439  ? 1154 THR   E HA   1 
ATOM   3148 H  HB   . THR   B 2 40  ? 18.08844  14.09674  16.25745 1.000 45.99453  ? 1154 THR   E HB   1 
ATOM   3149 H  HG1  . THR   B 2 40  ? 16.10652  13.58495  15.41024 1.000 49.40430  ? 1154 THR   E HG1  1 
ATOM   3150 H  HG21 . THR   B 2 40  ? 19.03583  14.37490  14.09509 1.000 45.67302  ? 1154 THR   E HG21 1 
ATOM   3151 H  HG22 . THR   B 2 40  ? 19.96650  13.53615  15.05575 1.000 45.67302  ? 1154 THR   E HG22 1 
ATOM   3152 H  HG23 . THR   B 2 40  ? 19.09614  12.80295  13.96150 1.000 45.67302  ? 1154 THR   E HG23 1 
ATOM   3153 N  N    . TYR   B 2 41  ? 20.18271  10.99614  16.59309 1.000 40.74165  ? 1155 TYR   E N    1 
ATOM   3154 C  CA   . TYR   B 2 41  ? 21.28630  10.57237  17.44740 1.000 34.38733  ? 1155 TYR   E CA   1 
ATOM   3155 C  C    . TYR   B 2 41  ? 22.47921  10.06311  16.65037 1.000 29.37992  ? 1155 TYR   E C    1 
ATOM   3156 O  O    . TYR   B 2 41  ? 22.42630  9.86538   15.44290 1.000 37.91197  ? 1155 TYR   E O    1 
ATOM   3157 C  CB   . TYR   B 2 41  ? 20.86178  9.46652   18.41863 1.000 37.03943  ? 1155 TYR   E CB   1 
ATOM   3158 C  CG   . TYR   B 2 41  ? 20.49044  8.15762   17.74966 1.000 32.06036  ? 1155 TYR   E CG   1 
ATOM   3159 C  CD1  . TYR   B 2 41  ? 19.22289  7.95740   17.26774 1.000 32.30103  ? 1155 TYR   E CD1  1 
ATOM   3160 C  CD2  . TYR   B 2 41  ? 21.38844  7.11132   17.64656 1.000 42.34740  ? 1155 TYR   E CD2  1 
ATOM   3161 C  CE1  . TYR   B 2 41  ? 18.85945  6.79321   16.69409 1.000 32.33151  ? 1155 TYR   E CE1  1 
ATOM   3162 C  CE2  . TYR   B 2 41  ? 21.01388  5.88929   17.05797 1.000 32.54776  ? 1155 TYR   E CE2  1 
ATOM   3163 C  CZ   . TYR   B 2 41  ? 19.74897  5.75714   16.58720 1.000 38.28704  ? 1155 TYR   E CZ   1 
ATOM   3164 O  OH   . TYR   B 2 41  ? 19.32582  4.59969   15.99074 1.000 33.47979  ? 1155 TYR   E OH   1 
ATOM   3165 H  H    . TYR   B 2 41  ? 20.18287  10.66139  15.80091 1.000 48.90526  ? 1155 TYR   E H    1 
ATOM   3166 H  HA   . TYR   B 2 41  ? 21.56292  11.37407  17.91820 1.000 41.28007  ? 1155 TYR   E HA   1 
ATOM   3167 H  HB2  . TYR   B 2 41  ? 21.59719  9.28806   19.02545 1.000 44.46260  ? 1155 TYR   E HB2  1 
ATOM   3168 H  HB3  . TYR   B 2 41  ? 20.08744  9.77202   18.91659 1.000 44.46260  ? 1155 TYR   E HB3  1 
ATOM   3169 H  HD1  . TYR   B 2 41  ? 18.59778  8.64234   17.33840 1.000 38.77651  ? 1155 TYR   E HD1  1 
ATOM   3170 H  HD2  . TYR   B 2 41  ? 22.25350  7.21686   17.97129 1.000 50.83216  ? 1155 TYR   E HD2  1 
ATOM   3171 H  HE1  . TYR   B 2 41  ? 17.99473  6.69219   16.36706 1.000 38.81309  ? 1155 TYR   E HE1  1 
ATOM   3172 H  HE2  . TYR   B 2 41  ? 21.62063  5.18747   16.99320 1.000 39.07258  ? 1155 TYR   E HE2  1 
ATOM   3173 H  HH   . TYR   B 2 41  ? 19.95729  4.04684   15.95611 1.000 40.19102  ? 1155 TYR   E HH   1 
ATOM   3174 N  N    . GLN   B 2 42  ? 23.55832  9.82578   17.36049 1.000 39.04000  ? 1156 GLN   E N    1 
ATOM   3175 C  CA   . GLN   B 2 42  ? 24.69589  9.12594   16.79339 1.000 35.73304  ? 1156 GLN   E CA   1 
ATOM   3176 C  C    . GLN   B 2 42  ? 25.01912  7.99013   17.73792 1.000 41.62550  ? 1156 GLN   E C    1 
ATOM   3177 O  O    . GLN   B 2 42  ? 24.83228  8.11736   18.94753 1.000 38.25860  ? 1156 GLN   E O    1 
ATOM   3178 C  CB   . GLN   B 2 42  ? 25.89602  10.03438  16.62545 1.000 39.87734  ? 1156 GLN   E CB   1 
ATOM   3179 C  CG   . GLN   B 2 42  ? 25.74227  11.14977  15.60735 1.000 43.69227  ? 1156 GLN   E CG   1 
ATOM   3180 C  CD   . GLN   B 2 42  ? 26.80557  12.22461  15.80361 1.000 41.67270  ? 1156 GLN   E CD   1 
ATOM   3181 O  OE1  . GLN   B 2 42  ? 27.10291  12.60238  16.91877 1.000 41.61482  ? 1156 GLN   E OE1  1 
ATOM   3182 N  NE2  . GLN   B 2 42  ? 27.39028  12.68537  14.72178 1.000 43.90946  ? 1156 GLN   E NE2  1 
ATOM   3183 H  H    . GLN   B 2 42  ? 23.66030  10.06098  18.18139 1.000 46.86328  ? 1156 GLN   E H    1 
ATOM   3184 H  HA   . GLN   B 2 42  ? 24.48957  8.77863   15.91152 1.000 42.89492  ? 1156 GLN   E HA   1 
ATOM   3185 H  HB2  . GLN   B 2 42  ? 26.08452  10.45028  17.48126 1.000 47.86808  ? 1156 GLN   E HB2  1 
ATOM   3186 H  HB3  . GLN   B 2 42  ? 26.65068  9.49255   16.34651 1.000 47.86808  ? 1156 GLN   E HB3  1 
ATOM   3187 H  HG2  . GLN   B 2 42  ? 25.83610  10.78520  14.71338 1.000 52.44600  ? 1156 GLN   E HG2  1 
ATOM   3188 H  HG3  . GLN   B 2 42  ? 24.86915  11.56010  15.70835 1.000 52.44600  ? 1156 GLN   E HG3  1 
ATOM   3189 H  HE21 . GLN   B 2 42  ? 27.16745  12.38001  13.94932 1.000 52.70663  ? 1156 GLN   E HE21 1 
ATOM   3190 H  HE22 . GLN   B 2 42  ? 27.99604  13.29246  14.78578 1.000 52.70663  ? 1156 GLN   E HE22 1 
ATOM   3191 N  N    . ILE   B 2 43  ? 25.42922  6.85665   17.18815 1.000 43.89013  ? 1157 ILE   E N    1 
ATOM   3192 C  CA   . ILE   B 2 43  ? 26.07760  5.87622   18.03672 1.000 47.87372  ? 1157 ILE   E CA   1 
ATOM   3193 C  C    . ILE   B 2 43  ? 27.46443  6.40507   18.34013 1.000 32.34328  ? 1157 ILE   E C    1 
ATOM   3194 O  O    . ILE   B 2 43  ? 28.06809  7.10104   17.52376 1.000 39.99476  ? 1157 ILE   E O    1 
ATOM   3195 C  CB   . ILE   B 2 43  ? 26.14774  4.47414   17.40278 1.000 41.41095  ? 1157 ILE   E CB   1 
ATOM   3196 C  CG1  . ILE   B 2 43  ? 26.91115  4.48697   16.08317 1.000 43.87748  ? 1157 ILE   E CG1  1 
ATOM   3197 C  CG2  . ILE   B 2 43  ? 24.74145  3.94168   17.17671 1.000 39.71143  ? 1157 ILE   E CG2  1 
ATOM   3198 C  CD1  . ILE   B 2 43  ? 27.20539  3.09858   15.50036 1.000 38.90072  ? 1157 ILE   E CD1  1 
ATOM   3199 H  H    . ILE   B 2 43  ? 25.34658  6.64127   16.35967 1.000 52.68343  ? 1157 ILE   E H    1 
ATOM   3200 H  HA   . ILE   B 2 43  ? 25.55708  5.76611   18.84779 1.000 57.46374  ? 1157 ILE   E HA   1 
ATOM   3201 H  HB   . ILE   B 2 43  ? 26.62726  3.89758   18.01804 1.000 49.70842  ? 1157 ILE   E HB   1 
ATOM   3202 H  HG12 . ILE   B 2 43  ? 26.38667  4.97364   15.42821 1.000 52.66825  ? 1157 ILE   E HG12 1 
ATOM   3203 H  HG13 . ILE   B 2 43  ? 27.76192  4.93129   16.22339 1.000 52.66825  ? 1157 ILE   E HG13 1 
ATOM   3204 H  HG21 . ILE   B 2 43  ? 24.79497  3.00847   16.91757 1.000 47.66899  ? 1157 ILE   E HG21 1 
ATOM   3205 H  HG22 . ILE   B 2 43  ? 24.23503  4.02797   17.99951 1.000 47.66899  ? 1157 ILE   E HG22 1 
ATOM   3206 H  HG23 . ILE   B 2 43  ? 24.31817  4.45686   16.47220 1.000 47.66899  ? 1157 ILE   E HG23 1 
ATOM   3207 H  HD11 . ILE   B 2 43  ? 27.76297  3.19832   14.71293 1.000 46.69614  ? 1157 ILE   E HD11 1 
ATOM   3208 H  HD12 . ILE   B 2 43  ? 27.66738  2.56740   16.16768 1.000 46.69614  ? 1157 ILE   E HD12 1 
ATOM   3209 H  HD13 . ILE   B 2 43  ? 26.36753  2.67269   15.26059 1.000 46.69614  ? 1157 ILE   E HD13 1 
ATOM   3210 N  N    . MET   B 2 44  ? 27.97524  6.05753   19.50585 1.000 44.89809  ? 1158 MET   E N    1 
ATOM   3211 C  CA   . MET   B 2 44  ? 29.28256  6.50111   19.95124 1.000 48.58185  ? 1158 MET   E CA   1 
ATOM   3212 C  C    . MET   B 2 44  ? 30.30155  5.37709   20.01506 1.000 52.24257  ? 1158 MET   E C    1 
ATOM   3213 O  O    . MET   B 2 44  ? 30.02678  4.28944   20.54346 1.000 42.70789  ? 1158 MET   E O    1 
ATOM   3214 C  CB   . MET   B 2 44  ? 29.16030  7.15083   21.31249 1.000 52.44936  ? 1158 MET   E CB   1 
ATOM   3215 C  CG   . MET   B 2 44  ? 28.44966  8.47353   21.17086 1.000 52.82572  ? 1158 MET   E CG   1 
ATOM   3216 S  SD   . MET   B 2 44  ? 28.49577  9.31424   22.70492 1.000 67.10299  ? 1158 MET   E SD   1 
ATOM   3217 C  CE   . MET   B 2 44  ? 30.11479  10.06007  22.53335 1.000 66.68128  ? 1158 MET   E CE   1 
ATOM   3218 H  H    . MET   B 2 44  ? 27.57261  5.55123   20.07255 1.000 53.89298  ? 1158 MET   E H    1 
ATOM   3219 H  HA   . MET   B 2 44  ? 29.61266  7.13554   19.29593 1.000 58.31349  ? 1158 MET   E HA   1 
ATOM   3220 H  HB2  . MET   B 2 44  ? 28.64702  6.57938   21.90484 1.000 62.95450  ? 1158 MET   E HB2  1 
ATOM   3221 H  HB3  . MET   B 2 44  ? 30.04304  7.30571   21.68355 1.000 62.95450  ? 1158 MET   E HB3  1 
ATOM   3222 H  HG2  . MET   B 2 44  ? 28.89297  9.01633   20.50023 1.000 63.40613  ? 1158 MET   E HG2  1 
ATOM   3223 H  HG3  . MET   B 2 44  ? 27.52444  8.32598   20.91969 1.000 63.40613  ? 1158 MET   E HG3  1 
ATOM   3224 H  HE1  . MET   B 2 44  ? 30.31900  10.56034  23.33891 1.000 80.03281  ? 1158 MET   E HE1  1 
ATOM   3225 H  HE2  . MET   B 2 44  ? 30.77301  9.35956   22.40322 1.000 80.03281  ? 1158 MET   E HE2  1 
ATOM   3226 H  HE3  . MET   B 2 44  ? 30.10888  10.65488  21.76715 1.000 80.03281  ? 1158 MET   E HE3  1 
ATOM   3227 N  N    . ARG   B 2 45  ? 31.47075  5.65719   19.46846 1.000 50.97088  ? 1159 ARG   E N    1 
ATOM   3228 C  CA   . ARG   B 2 45  ? 32.56653  4.71779   19.50287 1.000 49.51345  ? 1159 ARG   E CA   1 
ATOM   3229 C  C    . ARG   B 2 45  ? 33.01483  4.52848   20.93824 1.000 51.49095  ? 1159 ARG   E C    1 
ATOM   3230 O  O    . ARG   B 2 45  ? 33.26198  5.51311   21.64317 1.000 54.21279  ? 1159 ARG   E O    1 
ATOM   3231 C  CB   . ARG   B 2 45  ? 33.70884  5.23895   18.65269 1.000 51.60620  ? 1159 ARG   E CB   1 
ATOM   3232 C  CG   . ARG   B 2 45  ? 34.89802  4.31654   18.59320 1.000 56.10960  ? 1159 ARG   E CG   1 
ATOM   3233 C  CD   . ARG   B 2 45  ? 36.08452  4.98881   17.91872 1.000 55.04395  ? 1159 ARG   E CD   1 
ATOM   3234 N  NE   . ARG   B 2 45  ? 35.75985  5.48851   16.58698 1.000 50.60702  ? 1159 ARG   E NE   1 
ATOM   3235 C  CZ   . ARG   B 2 45  ? 35.91870  4.80281   15.46157 1.000 56.27920  ? 1159 ARG   E CZ   1 
ATOM   3236 N  NH1  . ARG   B 2 45  ? 36.39757  3.56680   15.46843 1.000 63.30103  ? 1159 ARG   E NH1  1 
ATOM   3237 N  NH2  . ARG   B 2 45  ? 35.58993  5.37198   14.29914 1.000 52.46459  ? 1159 ARG   E NH2  1 
ATOM   3238 H  H    . ARG   B 2 45  ? 31.65571  6.39474   19.06669 1.000 61.18033  ? 1159 ARG   E H    1 
ATOM   3239 H  HA   . ARG   B 2 45  ? 32.29005  3.85782   19.14942 1.000 59.43142  ? 1159 ARG   E HA   1 
ATOM   3240 H  HB2  . ARG   B 2 45  ? 33.38856  5.36652   17.74602 1.000 61.94272  ? 1159 ARG   E HB2  1 
ATOM   3241 H  HB3  . ARG   B 2 45  ? 34.00940  6.08472   19.02045 1.000 61.94272  ? 1159 ARG   E HB3  1 
ATOM   3242 H  HG2  . ARG   B 2 45  ? 35.15858  4.06823   19.49396 1.000 67.34680  ? 1159 ARG   E HG2  1 
ATOM   3243 H  HG3  . ARG   B 2 45  ? 34.66584  3.52388   18.08460 1.000 67.34680  ? 1159 ARG   E HG3  1 
ATOM   3244 H  HD2  . ARG   B 2 45  ? 36.37331  5.74022   18.45991 1.000 66.06801  ? 1159 ARG   E HD2  1 
ATOM   3245 H  HD3  . ARG   B 2 45  ? 36.80586  4.34621   17.83138 1.000 66.06801  ? 1159 ARG   E HD3  1 
ATOM   3246 H  HE   . ARG   B 2 45  ? 35.44239  6.28550   16.52672 1.000 60.74370  ? 1159 ARG   E HE   1 
ATOM   3247 H  HH11 . ARG   B 2 45  ? 36.61256  3.19308   16.21255 1.000 75.97651  ? 1159 ARG   E HH11 1 
ATOM   3248 H  HH12 . ARG   B 2 45  ? 36.49327  3.13862   14.72877 1.000 75.97651  ? 1159 ARG   E HH12 1 
ATOM   3249 H  HH21 . ARG   B 2 45  ? 35.27931  6.17381   14.28562 1.000 62.97278  ? 1159 ARG   E HH21 1 
ATOM   3250 H  HH22 . ARG   B 2 45  ? 35.68882  4.93670   13.56406 1.000 62.97278  ? 1159 ARG   E HH22 1 
ATOM   3251 N  N    . PRO   B 2 46  ? 33.11694  3.29250   21.41830 1.000 53.42219  ? 1160 PRO   E N    1 
ATOM   3252 C  CA   . PRO   B 2 46  ? 33.69165  3.07269   22.75079 1.000 64.42110  ? 1160 PRO   E CA   1 
ATOM   3253 C  C    . PRO   B 2 46  ? 35.14904  3.50189   22.78706 1.000 57.83890  ? 1160 PRO   E C    1 
ATOM   3254 O  O    . PRO   B 2 46  ? 35.86014  3.45109   21.78069 1.000 56.82389  ? 1160 PRO   E O    1 
ATOM   3255 C  CB   . PRO   B 2 46  ? 33.55088  1.56090   22.95810 1.000 49.24958  ? 1160 PRO   E CB   1 
ATOM   3256 C  CG   . PRO   B 2 46  ? 32.53388  1.12410   21.94045 1.000 51.22914  ? 1160 PRO   E CG   1 
ATOM   3257 C  CD   . PRO   B 2 46  ? 32.69722  2.03258   20.77971 1.000 52.21335  ? 1160 PRO   E CD   1 
ATOM   3258 H  HA   . PRO   B 2 46  ? 33.18649  3.54316   23.43225 1.000 77.32060  ? 1160 PRO   E HA   1 
ATOM   3259 H  HB2  . PRO   B 2 46  ? 34.40416  1.12550   22.80565 1.000 59.11477  ? 1160 PRO   E HB2  1 
ATOM   3260 H  HB3  . PRO   B 2 46  ? 33.24150  1.37821   23.85910 1.000 59.11477  ? 1160 PRO   E HB3  1 
ATOM   3261 H  HG2  . PRO   B 2 46  ? 32.70455  0.20470   21.68264 1.000 61.49025  ? 1160 PRO   E HG2  1 
ATOM   3262 H  HG3  . PRO   B 2 46  ? 31.64268  1.20364   22.31506 1.000 61.49025  ? 1160 PRO   E HG3  1 
ATOM   3263 H  HD2  . PRO   B 2 46  ? 33.38024  1.70460   20.17406 1.000 62.67130  ? 1160 PRO   E HD2  1 
ATOM   3264 H  HD3  . PRO   B 2 46  ? 31.85897  2.14513   20.30477 1.000 62.67130  ? 1160 PRO   E HD3  1 
ATOM   3265 N  N    . GLU   B 2 47  ? 35.59421  3.91925   23.96109 1.000 58.54244  ? 1161 GLU   E N    1 
ATOM   3266 C  CA   . GLU   B 2 47  ? 36.94950  4.44947   24.07674 1.000 68.84037  ? 1161 GLU   E CA   1 
ATOM   3267 C  C    . GLU   B 2 47  ? 37.95245  3.38655   24.52353 1.000 63.74709  ? 1161 GLU   E C    1 
ATOM   3268 O  O    . GLU   B 2 47  ? 37.67540  2.19044   24.42672 1.000 66.13779  ? 1161 GLU   E O    1 
ATOM   3269 C  CB   . GLU   B 2 47  ? 36.96509  5.62666   25.04606 1.000 80.27093  ? 1161 GLU   E CB   1 
ATOM   3270 C  CG   . GLU   B 2 47  ? 35.98863  6.73164   24.68132 1.000 98.15062  ? 1161 GLU   E CG   1 
ATOM   3271 C  CD   . GLU   B 2 47  ? 35.92901  7.83364   25.72819 1.000 95.09020  ? 1161 GLU   E CD   1 
ATOM   3272 O  OE1  . GLU   B 2 47  ? 35.54750  7.53914   26.88441 1.000 93.48330  ? 1161 GLU   E OE1  1 
ATOM   3273 O  OE2  . GLU   B 2 47  ? 36.27081  8.99030   25.39688 1.000 112.73706 ? 1161 GLU   E OE2  1 
ATOM   3274 H  H    . GLU   B 2 47  ? 35.14282  3.90760   24.69302 1.000 70.26620  ? 1161 GLU   E H    1 
ATOM   3275 H  HA   . GLU   B 2 47  ? 37.23598  4.75748   23.20269 1.000 82.62371  ? 1161 GLU   E HA   1 
ATOM   3276 H  HB2  . GLU   B 2 47  ? 36.73166  5.30518   25.93097 1.000 96.34039  ? 1161 GLU   E HB2  1 
ATOM   3277 H  HB3  . GLU   B 2 47  ? 37.85599  6.01016   25.05672 1.000 96.34039  ? 1161 GLU   E HB3  1 
ATOM   3278 H  HG2  . GLU   B 2 47  ? 36.26269  7.13091   23.84086 1.000 117.79601 ? 1161 GLU   E HG2  1 
ATOM   3279 H  HG3  . GLU   B 2 47  ? 35.10015  6.35228   24.59428 1.000 117.79601 ? 1161 GLU   E HG3  1 
HETATM 3280 C  C10  . A1H44 C 3 .   ? 12.30711  -2.45784  14.73933 1.000 43.01225  ? 1201 A1H44 A C10  1 
HETATM 3281 C  C11  . A1H44 C 3 .   ? 11.90050  -3.25940  11.13024 1.000 47.63088  ? 1201 A1H44 A C11  1 
HETATM 3282 C  C14  . A1H44 C 3 .   ? 12.01613  -4.39502  10.36281 1.000 45.97088  ? 1201 A1H44 A C14  1 
HETATM 3283 C  C15  . A1H44 C 3 .   ? 11.76555  -4.30108  9.00152  1.000 44.83528  ? 1201 A1H44 A C15  1 
HETATM 3284 C  C16  . A1H44 C 3 .   ? 11.35857  -3.10134  8.44329  1.000 48.08531  ? 1201 A1H44 A C16  1 
HETATM 3285 C  C17  . A1H44 C 3 .   ? 11.20934  -1.97070  9.23369  1.000 42.46966  ? 1201 A1H44 A C17  1 
HETATM 3286 C  C20  . A1H44 C 3 .   ? 12.36410  -2.44718  6.29061  1.000 48.01146  ? 1201 A1H44 A C20  1 
HETATM 3287 C  C21  . A1H44 C 3 .   ? 10.94753  -4.38095  6.32690  1.000 45.14167  ? 1201 A1H44 A C21  1 
HETATM 3288 C  C22  . A1H44 C 3 .   ? 9.93440   -2.15172  6.56537  1.000 50.42959  ? 1201 A1H44 A C22  1 
HETATM 3289 C  C01  . A1H44 C 3 .   ? 12.52672  -3.99735  16.59440 1.000 39.19845  ? 1201 A1H44 A C01  1 
HETATM 3290 C  C02  . A1H44 C 3 .   ? 12.61906  -5.29505  17.08557 1.000 40.82554  ? 1201 A1H44 A C02  1 
HETATM 3291 C  C03  . A1H44 C 3 .   ? 12.59009  -6.37190  16.24432 1.000 36.65911  ? 1201 A1H44 A C03  1 
HETATM 3292 C  C04  . A1H44 C 3 .   ? 12.42281  -6.13375  14.90920 1.000 42.41471  ? 1201 A1H44 A C04  1 
HETATM 3293 C  C05  . A1H44 C 3 .   ? 12.35927  -4.82192  14.42047 1.000 41.69426  ? 1201 A1H44 A C05  1 
HETATM 3294 C  C06  . A1H44 C 3 .   ? 12.40763  -3.74354  15.23795 1.000 40.26587  ? 1201 A1H44 A C06  1 
HETATM 3295 C  C08  . A1H44 C 3 .   ? 12.11677  -3.38711  12.63489 1.000 48.66531  ? 1201 A1H44 A C08  1 
HETATM 3296 C  C18  . A1H44 C 3 .   ? 11.44822  -2.06314  10.59525 1.000 44.41716  ? 1201 A1H44 A C18  1 
HETATM 3297 C  C19  . A1H44 C 3 .   ? 11.11991  -3.02044  6.91717  1.000 44.35902  ? 1201 A1H44 A C19  1 
HETATM 3298 C  C23  . A1H44 C 3 .   ? 12.87700  -8.52540  14.15840 1.000 52.95045  ? 1201 A1H44 A C23  1 
HETATM 3299 C  C25  . A1H44 C 3 .   ? 12.91677  -9.44494  12.96752 1.000 53.57338  ? 1201 A1H44 A C25  1 
HETATM 3300 C  C26  . A1H44 C 3 .   ? 11.64039  -10.23347 12.84331 1.000 60.95081  ? 1201 A1H44 A C26  1 
HETATM 3301 N  N07  . A1H44 C 3 .   ? 12.21224  -4.64147  13.12760 1.000 38.43985  ? 1201 A1H44 A N07  1 
HETATM 3302 N  N09  . A1H44 C 3 .   ? 12.15069  -2.30035  13.43090 1.000 35.70641  ? 1201 A1H44 A N09  1 
HETATM 3303 N  N13  . A1H44 C 3 .   ? 12.42511  -7.16534  13.92016 1.000 45.28208  ? 1201 A1H44 A N13  1 
HETATM 3304 O  O12  . A1H44 C 3 .   ? 12.35893  -1.47774  15.42796 1.000 34.55498  ? 1201 A1H44 A O12  1 
HETATM 3305 O  O24  . A1H44 C 3 .   ? 13.19645  -8.93510  15.21779 1.000 54.17141  ? 1201 A1H44 A O24  1 
HETATM 3306 O  O27  . A1H44 C 3 .   ? 11.98737  -11.29002 11.99892 1.000 47.06022  ? 1201 A1H44 A O27  1 
HETATM 3307 O  O28  . A1H44 C 3 .   ? 13.07134  -8.69477  11.79189 1.000 47.93237  ? 1201 A1H44 A O28  1 
HETATM 3308 H  H141 . A1H44 C 3 .   ? 12.29649  -5.34125  10.81125 1.000 55.18033  ? 1201 A1H44 A H141 1 
HETATM 3309 H  H151 . A1H44 C 3 .   ? 11.88938  -5.17362  8.37034  1.000 53.81761  ? 1201 A1H44 A H151 1 
HETATM 3310 H  H171 . A1H44 C 3 .   ? 10.91031  -1.02903  8.79259  1.000 50.97887  ? 1201 A1H44 A H171 1 
HETATM 3311 H  H202 . A1H44 C 3 .   ? 13.20551  -3.10380  6.49127  1.000 57.62902  ? 1201 A1H44 A H202 1 
HETATM 3312 H  H201 . A1H44 C 3 .   ? 12.56180  -1.46583  6.71164  1.000 57.62902  ? 1201 A1H44 A H201 1 
HETATM 3313 H  H203 . A1H44 C 3 .   ? 12.22101  -2.35906  5.21769  1.000 57.62902  ? 1201 A1H44 A H203 1 
HETATM 3314 H  H211 . A1H44 C 3 .   ? 11.89643  -4.91043  6.35514  1.000 54.18527  ? 1201 A1H44 A H211 1 
HETATM 3315 H  H212 . A1H44 C 3 .   ? 10.61400  -4.28863  5.29646  1.000 54.18527  ? 1201 A1H44 A H212 1 
HETATM 3316 H  H213 . A1H44 C 3 .   ? 10.20685  -4.93277  6.90002  1.000 54.18527  ? 1201 A1H44 A H213 1 
HETATM 3317 H  H223 . A1H44 C 3 .   ? 10.17357  -1.10891  6.77381  1.000 60.53078  ? 1201 A1H44 A H223 1 
HETATM 3318 H  H222 . A1H44 C 3 .   ? 9.07332   -2.45324  7.16178  1.000 60.53078  ? 1201 A1H44 A H222 1 
HETATM 3319 H  H221 . A1H44 C 3 .   ? 9.70132   -2.26646  5.50678  1.000 60.53078  ? 1201 A1H44 A H221 1 
HETATM 3320 H  H011 . A1H44 C 3 .   ? 12.54856  -3.16257  17.29182 1.000 47.05342  ? 1201 A1H44 A H011 1 
HETATM 3321 H  H021 . A1H44 C 3 .   ? 12.71560  -5.45514  18.15333 1.000 49.00592  ? 1201 A1H44 A H021 1 
HETATM 3322 H  H031 . A1H44 C 3 .   ? 12.69586  -7.37700  16.62222 1.000 44.00621  ? 1201 A1H44 A H031 1 
HETATM 3323 H  H181 . A1H44 C 3 .   ? 11.28233  -1.20443  11.23906 1.000 53.31586  ? 1201 A1H44 A H181 1 
HETATM 3324 H  H251 . A1H44 C 3 .   ? 13.75138  -10.12378 13.10835 1.000 64.30334  ? 1201 A1H44 A H251 1 
HETATM 3325 H  H261 . A1H44 C 3 .   ? 10.85390  -9.62991  12.40489 1.000 73.15625  ? 1201 A1H44 A H261 1 
HETATM 3326 H  H262 . A1H44 C 3 .   ? 11.31711  -10.60112 13.81046 1.000 73.15625  ? 1201 A1H44 A H262 1 
HETATM 3327 H  H091 . A1H44 C 3 .   ? 12.05887  -1.38363  13.03950 1.000 42.86297  ? 1201 A1H44 A H091 1 
HETATM 3328 H  H131 . A1H44 C 3 .   ? 12.09388  -6.93585  13.00385 1.000 54.35377  ? 1201 A1H44 A H131 1 
HETATM 3329 H  H271 . A1H44 C 3 .   ? 12.41149  -10.94843 11.23653 1.000 56.48754  ? 1201 A1H44 A H271 1 
HETATM 3330 H  H281 . A1H44 C 3 .   ? 13.80487  -8.10664  11.89235 1.000 57.53412  ? 1201 A1H44 A H281 1 
HETATM 3331 ZN ZN   . ZN    D 4 .   ? 28.02450  7.63055   7.52725  1.000 41.92555  ? 1202 ZN    A ZN   1 
HETATM 3332 S  S    . SO4   E 5 .   ? 20.27219  -10.26662 19.03610 1.000 40.83975  ? 1203 SO4   A S    1 
HETATM 3333 O  O1   . SO4   E 5 .   ? 20.67694  -11.28206 18.08554 1.000 43.04854  ? 1203 SO4   A O1   1 
HETATM 3334 O  O2   . SO4   E 5 .   ? 20.02829  -9.04402  18.27711 1.000 41.27400  ? 1203 SO4   A O2   1 
HETATM 3335 O  O3   . SO4   E 5 .   ? 19.05118  -10.59998 19.73697 1.000 42.00110  ? 1203 SO4   A O3   1 
HETATM 3336 O  O4   . SO4   E 5 .   ? 21.34213  -10.10364 19.99793 1.000 32.92569  ? 1203 SO4   A O4   1 
HETATM 3337 S  S    . SO4   F 5 .   ? 32.16088  4.10811   26.29813 1.000 70.51647  ? 1204 SO4   A S    1 
HETATM 3338 O  O1   . SO4   F 5 .   ? 31.97421  4.63540   24.94099 1.000 70.99160  ? 1204 SO4   A O1   1 
HETATM 3339 O  O2   . SO4   F 5 .   ? 32.91557  2.86560   26.33527 1.000 60.00265  ? 1204 SO4   A O2   1 
HETATM 3340 O  O3   . SO4   F 5 .   ? 30.84447  3.91957   26.88490 1.000 68.81589  ? 1204 SO4   A O3   1 
HETATM 3341 O  O4   . SO4   F 5 .   ? 32.92033  5.08470   27.07328 1.000 94.00610  ? 1204 SO4   A O4   1 
HETATM 3342 O  O    . HOH   G 6 .   ? -12.30699 -0.05890  28.38231 1.000 43.93382  ? 1301 HOH   A O    1 
HETATM 3343 O  O    . HOH   G 6 .   ? 30.64809  -6.03054  14.73200 1.000 51.33032  ? 1302 HOH   A O    1 
HETATM 3344 O  O    . HOH   G 6 .   ? 7.26358   -3.39095  27.45249 1.000 44.02858  ? 1303 HOH   A O    1 
HETATM 3345 O  O    . HOH   G 6 .   ? 18.06371  12.16822  30.45096 1.000 48.84784  ? 1304 HOH   A O    1 
HETATM 3346 O  O    . HOH   G 6 .   ? 32.50587  3.18050   11.56219 1.000 43.38812  ? 1305 HOH   A O    1 
HETATM 3347 O  O    . HOH   G 6 .   ? 24.35347  2.31234   2.42093  1.000 50.07406  ? 1306 HOH   A O    1 
HETATM 3348 O  O    . HOH   G 6 .   ? 14.66098  4.71525   11.82295 1.000 46.87038  ? 1307 HOH   A O    1 
HETATM 3349 O  O    . HOH   G 6 .   ? 10.88653  21.04306  15.42390 1.000 46.78588  ? 1308 HOH   A O    1 
HETATM 3350 O  O    . HOH   G 6 .   ? 11.22635  21.71616  25.51992 1.000 42.72471  ? 1309 HOH   A O    1 
HETATM 3351 O  O    . HOH   G 6 .   ? 5.96425   19.06513  10.42299 1.000 44.22183  ? 1310 HOH   A O    1 
HETATM 3352 O  O    . HOH   G 6 .   ? -4.381    -0.588    31.022   1.000 36.41190  ? 1311 HOH   A O    1 
HETATM 3353 O  O    . HOH   G 6 .   ? 15.74735  18.55977  20.97349 1.000 35.59440  ? 1312 HOH   A O    1 
HETATM 3354 O  O    . HOH   G 6 .   ? 12.69923  13.26988  33.50788 1.000 41.72155  ? 1313 HOH   A O    1 
HETATM 3355 O  O    . HOH   G 6 .   ? 24.73401  -3.12512  17.87195 1.000 35.35293  ? 1314 HOH   A O    1 
HETATM 3356 O  O    . HOH   G 6 .   ? 9.31368   2.23624   27.67410 1.000 47.09116  ? 1315 HOH   A O    1 
HETATM 3357 O  O    . HOH   G 6 .   ? 24.15593  -5.28085  15.84552 1.000 31.14744  ? 1316 HOH   A O    1 
HETATM 3358 O  O    . HOH   G 6 .   ? 15.83800  -3.55416  4.31585  1.000 44.88004  ? 1317 HOH   A O    1 
HETATM 3359 O  O    . HOH   G 6 .   ? 23.26773  -0.00731  10.87906 1.000 38.24907  ? 1318 HOH   A O    1 
HETATM 3360 O  O    . HOH   G 6 .   ? 1.448     -1.491    30.041   0.500 39.86194  ? 1319 HOH   A O    1 
HETATM 3361 O  O    . HOH   G 6 .   ? 22.38571  -1.91391  17.21836 1.000 27.96123  ? 1320 HOH   A O    1 
HETATM 3362 O  O    . HOH   G 6 .   ? 24.01142  3.67793   27.34306 1.000 40.22650  ? 1321 HOH   A O    1 
HETATM 3363 O  O    . HOH   G 6 .   ? -9.12098  -10.35335 26.31364 1.000 44.40247  ? 1322 HOH   A O    1 
HETATM 3364 O  O    . HOH   G 6 .   ? 28.63168  -2.97860  11.74423 1.000 46.24357  ? 1323 HOH   A O    1 
HETATM 3365 O  O    . HOH   G 6 .   ? 25.53783  0.07824   27.34646 1.000 47.60032  ? 1324 HOH   A O    1 
HETATM 3366 O  O    . HOH   G 6 .   ? 12.12131  -0.19492  26.80856 1.000 45.83725  ? 1325 HOH   A O    1 
HETATM 3367 O  O    . HOH   G 6 .   ? 22.90174  -8.11398  9.59614  1.000 47.20402  ? 1326 HOH   A O    1 
HETATM 3368 O  O    . HOH   G 6 .   ? 10.73622  -7.61545  28.75890 1.000 50.13438  ? 1327 HOH   A O    1 
HETATM 3369 O  O    . HOH   G 6 .   ? -0.42629  -6.12010  31.46638 1.000 40.61828  ? 1328 HOH   A O    1 
HETATM 3370 O  O    . HOH   G 6 .   ? 0.17014   -16.33280 25.31799 1.000 47.07531  ? 1329 HOH   A O    1 
HETATM 3371 O  O    . HOH   G 6 .   ? 25.93211  7.51258   14.13036 1.000 42.46086  ? 1330 HOH   A O    1 
HETATM 3372 O  O    . HOH   G 6 .   ? 30.35792  -8.37039  13.93851 1.000 40.61241  ? 1331 HOH   A O    1 
HETATM 3373 O  O    . HOH   G 6 .   ? 29.63639  9.41798   17.34650 1.000 38.27228  ? 1332 HOH   A O    1 
HETATM 3374 O  O    . HOH   G 6 .   ? 25.01348  6.50115   11.16187 1.000 46.66405  ? 1333 HOH   A O    1 
HETATM 3375 O  O    . HOH   G 6 .   ? 13.184    7.371     31.721   1.000 40.63990  ? 1334 HOH   A O    1 
HETATM 3376 O  O    . HOH   G 6 .   ? 1.13458   -8.62750  28.18239 1.000 43.07205  ? 1335 HOH   A O    1 
HETATM 3377 O  O    . HOH   G 6 .   ? -8.96345  3.54899   14.61592 1.000 42.34913  ? 1336 HOH   A O    1 
HETATM 3378 O  O    . HOH   G 6 .   ? 23.32627  -6.30463  6.23023  1.000 46.03827  ? 1337 HOH   A O    1 
HETATM 3379 O  O    . HOH   G 6 .   ? -10.79933 8.63419   18.54201 1.000 53.90097  ? 1338 HOH   A O    1 
HETATM 3380 O  O    . HOH   G 6 .   ? 8.29170   -3.64077  11.07108 1.000 40.30976  ? 1339 HOH   A O    1 
HETATM 3381 O  O    . HOH   G 6 .   ? 21.33608  0.73932   3.73305  1.000 53.32404  ? 1340 HOH   A O    1 
HETATM 3382 O  O    . HOH   G 6 .   ? 8.69610   0.39674   9.45853  1.000 40.95216  ? 1341 HOH   A O    1 
HETATM 3383 O  O    . HOH   G 6 .   ? -3.39636  -8.04965  28.44018 1.000 41.74340  ? 1342 HOH   A O    1 
HETATM 3384 O  O    . HOH   G 6 .   ? 22.27501  -9.65616  16.39339 1.000 46.19660  ? 1343 HOH   A O    1 
HETATM 3385 O  O    . HOH   G 6 .   ? -4.37418  1.32529   19.91701 1.000 42.93013  ? 1344 HOH   A O    1 
HETATM 3386 O  O    . HOH   G 6 .   ? -6.20239  0.57988   29.44610 1.000 42.82748  ? 1345 HOH   A O    1 
HETATM 3387 O  O    . HOH   G 6 .   ? -2.21404  6.52600   14.10152 1.000 48.91629  ? 1346 HOH   A O    1 
HETATM 3388 O  O    . HOH   G 6 .   ? 30.39046  -3.71747  13.35629 1.000 52.64706  ? 1347 HOH   A O    1 
HETATM 3389 O  O    . HOH   G 6 .   ? -3.32228  4.62167   28.55376 1.000 44.45751  ? 1348 HOH   A O    1 
HETATM 3390 O  O    . HOH   G 6 .   ? -14.19035 -5.66419  29.06496 1.000 58.35006  ? 1349 HOH   A O    1 
HETATM 3391 O  O    . HOH   G 6 .   ? 10.973    5.565     31.517   1.000 49.73099  ? 1350 HOH   A O    1 
HETATM 3392 O  O    . HOH   G 6 .   ? 29.24243  -1.80014  7.44463  1.000 43.57145  ? 1351 HOH   A O    1 
HETATM 3393 O  O    . HOH   G 6 .   ? 9.806     23.574    18.214   1.000 44.57914  ? 1352 HOH   A O    1 
HETATM 3394 O  O    . HOH   G 6 .   ? -1.98308  0.07872   29.91070 1.000 43.11395  ? 1353 HOH   A O    1 
HETATM 3395 O  O    . HOH   G 6 .   ? -4.482    -8.931    31.143   1.000 41.07246  ? 1354 HOH   A O    1 
HETATM 3396 O  O    . HOH   G 6 .   ? 23.78369  12.24830  24.90493 1.000 41.24013  ? 1355 HOH   A O    1 
HETATM 3397 O  O    . HOH   G 6 .   ? 28.14597  -2.92099  20.61409 1.000 40.50082  ? 1356 HOH   A O    1 
HETATM 3398 O  O    . HOH   G 6 .   ? -13.035   -8.833    28.511   1.000 42.05500  ? 1357 HOH   A O    1 
HETATM 3399 O  O    . HOH   G 6 .   ? 6.10646   -20.44680 22.79915 1.000 47.13680  ? 1358 HOH   A O    1 
HETATM 3400 O  O    . HOH   G 6 .   ? 32.47474  6.16668   11.45194 1.000 43.49145  ? 1359 HOH   A O    1 
HETATM 3401 O  O    . HOH   G 6 .   ? 20.75189  -0.02202  10.90365 1.000 39.93831  ? 1360 HOH   A O    1 
HETATM 3402 O  O    . HOH   G 6 .   ? -8.79019  5.05574   24.26627 1.000 50.10084  ? 1361 HOH   A O    1 
HETATM 3403 O  O    . HOH   G 6 .   ? -1.17033  -10.05735 27.58303 1.000 46.37945  ? 1362 HOH   A O    1 
HETATM 3404 O  O    . HOH   G 6 .   ? 24.64778  16.70113  21.53795 1.000 52.96751  ? 1363 HOH   A O    1 
HETATM 3405 O  O    . HOH   G 6 .   ? -2.40190  8.72857   26.40120 1.000 46.34868  ? 1364 HOH   A O    1 
HETATM 3406 O  O    . HOH   G 6 .   ? -15.72711 -6.63002  19.67011 1.000 53.26999  ? 1365 HOH   A O    1 
HETATM 3407 O  O    . HOH   G 6 .   ? 31.74677  6.29761   8.99498  1.000 46.71228  ? 1366 HOH   A O    1 
HETATM 3408 O  O    . HOH   G 6 .   ? -8.26189  2.46323   26.87546 1.000 50.25068  ? 1367 HOH   A O    1 
HETATM 3409 O  O    . HOH   G 6 .   ? 25.53698  8.48694   27.63952 1.000 52.10185  ? 1368 HOH   A O    1 
HETATM 3410 O  O    . HOH   G 6 .   ? 14.30803  11.31970  33.66212 1.000 37.67954  ? 1369 HOH   A O    1 
HETATM 3411 O  O    . HOH   G 6 .   ? 24.85327  6.05725   28.57309 1.000 56.48989  ? 1370 HOH   A O    1 
HETATM 3412 O  O    . HOH   G 6 .   ? -5.94926  2.98471   27.94652 1.000 47.41311  ? 1371 HOH   A O    1 
HETATM 3413 O  O    . HOH   G 6 .   ? 13.203    8.876     33.781   1.000 45.57521  ? 1372 HOH   A O    1 
HETATM 3414 O  O    . HOH   H 6 .   ? 16.68399  -11.99477 29.32942 1.000 57.73850  ? 1201 HOH   E O    1 
HETATM 3415 O  O    . HOH   H 6 .   ? 3.46520   -10.00627 26.87499 1.000 44.58119  ? 1202 HOH   E O    1 
HETATM 3416 O  O    . HOH   H 6 .   ? 29.79029  3.82303   23.02061 1.000 47.45022  ? 1203 HOH   E O    1 
HETATM 3417 O  O    . HOH   H 6 .   ? 15.67995  -7.61348  22.13226 1.000 42.96831  ? 1204 HOH   E O    1 
HETATM 3418 O  O    . HOH   H 6 .   ? -2.71040  -6.34245  16.21898 1.000 38.04506  ? 1205 HOH   E O    1 
HETATM 3419 O  O    . HOH   H 6 .   ? 18.92565  -5.30679  28.14499 1.000 38.17858  ? 1206 HOH   E O    1 
HETATM 3420 O  O    . HOH   H 6 .   ? 14.82993  14.44627  16.50604 1.000 40.65421  ? 1207 HOH   E O    1 
HETATM 3421 O  O    . HOH   H 6 .   ? 29.13304  11.75720  18.42584 1.000 47.55021  ? 1208 HOH   E O    1 
HETATM 3422 O  O    . HOH   H 6 .   ? 34.43575  7.49660   12.94339 1.000 50.46272  ? 1209 HOH   E O    1 
HETATM 3423 O  O    . HOH   H 6 .   ? 14.09011  -5.47871  22.84813 1.000 32.08432  ? 1210 HOH   E O    1 
HETATM 3424 O  O    . HOH   H 6 .   ? -7.34975  -8.79535  17.15291 1.000 50.34008  ? 1211 HOH   E O    1 
HETATM 3425 O  O    . HOH   H 6 .   ? 31.87272  8.22701   18.25310 1.000 45.18402  ? 1212 HOH   E O    1 
HETATM 3426 O  O    . HOH   H 6 .   ? 3.85410   11.82596  25.77040 1.000 45.25373  ? 1213 HOH   E O    1 
HETATM 3427 O  O    . HOH   H 6 .   ? -2.79315  -1.11416  9.36811  1.000 50.09330  ? 1214 HOH   E O    1 
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