data_8S4J
# 
_entry.id   8S4J 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8S4J         pdb_00008s4j 10.2210/pdb8s4j/pdb 
WWPDB D_1292136629 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2024-11-06 
2 'Structure model' 1 1 2024-12-04 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.country'                 
2 2 'Structure model' '_citation.journal_abbrev'          
3 2 'Structure model' '_citation.journal_id_CSD'          
4 2 'Structure model' '_citation.journal_id_ISSN'         
5 2 'Structure model' '_citation.journal_volume'          
6 2 'Structure model' '_citation.pdbx_database_id_DOI'    
7 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
8 2 'Structure model' '_citation.title'                   
9 2 'Structure model' '_citation.year'                    
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8S4J 
_pdbx_database_status.recvd_initial_deposition_date   2024-02-21 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              c.mulligan@kent.ac.uk 
_pdbx_contact_author.name_first         Christopher 
_pdbx_contact_author.name_last          Mulligan 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-5157-4651 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Mulligan, C.' 1 0000-0001-5157-4651 
'Daab, A.'     2 0009-0006-9320-7378 
'Davies, J.'   3 0009-0006-5183-0436 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            J.Gen.Physiol. 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1540-7748 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            156 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Structure and selectivity of a glutamate-specific TAXI TRAP binding protein from Vibrio cholerae.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1085/jgp.202413584 
_citation.pdbx_database_id_PubMed   39556531 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Davies, J.F.S.'   1 0009-0006-5183-0436 
primary 'Daab, A.'         2 0009-0006-9320-7378 
primary 'Massouh, N.'      3 0009-0009-9335-9285 
primary 'Kirkland, C.'     4 0000-0003-1030-393X 
primary 'Strongitharm, B.' 5 ?                   
primary 'Leech, A.'        6 0000-0001-6918-1469 
primary 'Farre, M.'        7 0000-0001-9170-5767 
primary 'Thomas, G.H.'     8 0000-0002-9763-1313 
primary 'Mulligan, C.'     9 0000-0001-5157-4651 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'TAXI family TRAP transporter solute-binding subunit' 32558.564 1   ? ? ? ? 
2 non-polymer syn 'GLUTAMIC ACID'                                       147.129   1   ? ? ? ? 
3 non-polymer syn 'SODIUM ION'                                          22.990    5   ? ? ? ? 
4 water       nat water                                                 18.015    258 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;RAQDFITIGTGSVTGVYYPTGGAICKLVNKDRKDHNIRCSVESTGGSIYNVNTIRSGELDFGIVQSDWQYHGYNGTSEFA
EQGPYKKLRAVFSMHTEPFNIIARADSGIENVKDLAGKRVNIGNPGSGDRATMQVVMDAFGWNNDSFKLAAELKGSERSQ
ALCDNKIDAFIYMVGHPNGAIKEATTSCAAKLVPATGPEIEKIVANNPYYAYSVVPAGMYSGTDQEVKSFGVAATLVTTE
EVSEAVVYNLTKAVFENFDTFTRLHPAFANLKKEDMVTAGNSIPLHPGAVKYYKEAGLIK
;
_entity_poly.pdbx_seq_one_letter_code_can   
;RAQDFITIGTGSVTGVYYPTGGAICKLVNKDRKDHNIRCSVESTGGSIYNVNTIRSGELDFGIVQSDWQYHGYNGTSEFA
EQGPYKKLRAVFSMHTEPFNIIARADSGIENVKDLAGKRVNIGNPGSGDRATMQVVMDAFGWNNDSFKLAAELKGSERSQ
ALCDNKIDAFIYMVGHPNGAIKEATTSCAAKLVPATGPEIEKIVANNPYYAYSVVPAGMYSGTDQEVKSFGVAATLVTTE
EVSEAVVYNLTKAVFENFDTFTRLHPAFANLKKEDMVTAGNSIPLHPGAVKYYKEAGLIK
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'GLUTAMIC ACID' GLU 
3 'SODIUM ION'    NA  
4 water           HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   ARG n 
1 2   ALA n 
1 3   GLN n 
1 4   ASP n 
1 5   PHE n 
1 6   ILE n 
1 7   THR n 
1 8   ILE n 
1 9   GLY n 
1 10  THR n 
1 11  GLY n 
1 12  SER n 
1 13  VAL n 
1 14  THR n 
1 15  GLY n 
1 16  VAL n 
1 17  TYR n 
1 18  TYR n 
1 19  PRO n 
1 20  THR n 
1 21  GLY n 
1 22  GLY n 
1 23  ALA n 
1 24  ILE n 
1 25  CYS n 
1 26  LYS n 
1 27  LEU n 
1 28  VAL n 
1 29  ASN n 
1 30  LYS n 
1 31  ASP n 
1 32  ARG n 
1 33  LYS n 
1 34  ASP n 
1 35  HIS n 
1 36  ASN n 
1 37  ILE n 
1 38  ARG n 
1 39  CYS n 
1 40  SER n 
1 41  VAL n 
1 42  GLU n 
1 43  SER n 
1 44  THR n 
1 45  GLY n 
1 46  GLY n 
1 47  SER n 
1 48  ILE n 
1 49  TYR n 
1 50  ASN n 
1 51  VAL n 
1 52  ASN n 
1 53  THR n 
1 54  ILE n 
1 55  ARG n 
1 56  SER n 
1 57  GLY n 
1 58  GLU n 
1 59  LEU n 
1 60  ASP n 
1 61  PHE n 
1 62  GLY n 
1 63  ILE n 
1 64  VAL n 
1 65  GLN n 
1 66  SER n 
1 67  ASP n 
1 68  TRP n 
1 69  GLN n 
1 70  TYR n 
1 71  HIS n 
1 72  GLY n 
1 73  TYR n 
1 74  ASN n 
1 75  GLY n 
1 76  THR n 
1 77  SER n 
1 78  GLU n 
1 79  PHE n 
1 80  ALA n 
1 81  GLU n 
1 82  GLN n 
1 83  GLY n 
1 84  PRO n 
1 85  TYR n 
1 86  LYS n 
1 87  LYS n 
1 88  LEU n 
1 89  ARG n 
1 90  ALA n 
1 91  VAL n 
1 92  PHE n 
1 93  SER n 
1 94  MET n 
1 95  HIS n 
1 96  THR n 
1 97  GLU n 
1 98  PRO n 
1 99  PHE n 
1 100 ASN n 
1 101 ILE n 
1 102 ILE n 
1 103 ALA n 
1 104 ARG n 
1 105 ALA n 
1 106 ASP n 
1 107 SER n 
1 108 GLY n 
1 109 ILE n 
1 110 GLU n 
1 111 ASN n 
1 112 VAL n 
1 113 LYS n 
1 114 ASP n 
1 115 LEU n 
1 116 ALA n 
1 117 GLY n 
1 118 LYS n 
1 119 ARG n 
1 120 VAL n 
1 121 ASN n 
1 122 ILE n 
1 123 GLY n 
1 124 ASN n 
1 125 PRO n 
1 126 GLY n 
1 127 SER n 
1 128 GLY n 
1 129 ASP n 
1 130 ARG n 
1 131 ALA n 
1 132 THR n 
1 133 MET n 
1 134 GLN n 
1 135 VAL n 
1 136 VAL n 
1 137 MET n 
1 138 ASP n 
1 139 ALA n 
1 140 PHE n 
1 141 GLY n 
1 142 TRP n 
1 143 ASN n 
1 144 ASN n 
1 145 ASP n 
1 146 SER n 
1 147 PHE n 
1 148 LYS n 
1 149 LEU n 
1 150 ALA n 
1 151 ALA n 
1 152 GLU n 
1 153 LEU n 
1 154 LYS n 
1 155 GLY n 
1 156 SER n 
1 157 GLU n 
1 158 ARG n 
1 159 SER n 
1 160 GLN n 
1 161 ALA n 
1 162 LEU n 
1 163 CYS n 
1 164 ASP n 
1 165 ASN n 
1 166 LYS n 
1 167 ILE n 
1 168 ASP n 
1 169 ALA n 
1 170 PHE n 
1 171 ILE n 
1 172 TYR n 
1 173 MET n 
1 174 VAL n 
1 175 GLY n 
1 176 HIS n 
1 177 PRO n 
1 178 ASN n 
1 179 GLY n 
1 180 ALA n 
1 181 ILE n 
1 182 LYS n 
1 183 GLU n 
1 184 ALA n 
1 185 THR n 
1 186 THR n 
1 187 SER n 
1 188 CYS n 
1 189 ALA n 
1 190 ALA n 
1 191 LYS n 
1 192 LEU n 
1 193 VAL n 
1 194 PRO n 
1 195 ALA n 
1 196 THR n 
1 197 GLY n 
1 198 PRO n 
1 199 GLU n 
1 200 ILE n 
1 201 GLU n 
1 202 LYS n 
1 203 ILE n 
1 204 VAL n 
1 205 ALA n 
1 206 ASN n 
1 207 ASN n 
1 208 PRO n 
1 209 TYR n 
1 210 TYR n 
1 211 ALA n 
1 212 TYR n 
1 213 SER n 
1 214 VAL n 
1 215 VAL n 
1 216 PRO n 
1 217 ALA n 
1 218 GLY n 
1 219 MET n 
1 220 TYR n 
1 221 SER n 
1 222 GLY n 
1 223 THR n 
1 224 ASP n 
1 225 GLN n 
1 226 GLU n 
1 227 VAL n 
1 228 LYS n 
1 229 SER n 
1 230 PHE n 
1 231 GLY n 
1 232 VAL n 
1 233 ALA n 
1 234 ALA n 
1 235 THR n 
1 236 LEU n 
1 237 VAL n 
1 238 THR n 
1 239 THR n 
1 240 GLU n 
1 241 GLU n 
1 242 VAL n 
1 243 SER n 
1 244 GLU n 
1 245 ALA n 
1 246 VAL n 
1 247 VAL n 
1 248 TYR n 
1 249 ASN n 
1 250 LEU n 
1 251 THR n 
1 252 LYS n 
1 253 ALA n 
1 254 VAL n 
1 255 PHE n 
1 256 GLU n 
1 257 ASN n 
1 258 PHE n 
1 259 ASP n 
1 260 THR n 
1 261 PHE n 
1 262 THR n 
1 263 ARG n 
1 264 LEU n 
1 265 HIS n 
1 266 PRO n 
1 267 ALA n 
1 268 PHE n 
1 269 ALA n 
1 270 ASN n 
1 271 LEU n 
1 272 LYS n 
1 273 LYS n 
1 274 GLU n 
1 275 ASP n 
1 276 MET n 
1 277 VAL n 
1 278 THR n 
1 279 ALA n 
1 280 GLY n 
1 281 ASN n 
1 282 SER n 
1 283 ILE n 
1 284 PRO n 
1 285 LEU n 
1 286 HIS n 
1 287 PRO n 
1 288 GLY n 
1 289 ALA n 
1 290 VAL n 
1 291 LYS n 
1 292 TYR n 
1 293 TYR n 
1 294 LYS n 
1 295 GLU n 
1 296 ALA n 
1 297 GLY n 
1 298 LEU n 
1 299 ILE n 
1 300 LYS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   300 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'D6U24_12840, I7465_15265' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Vibrio cholerae' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     666 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
NA  non-polymer         . 'SODIUM ION'    ? 'Na 1'           22.990  
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   ARG 1   29  29  ARG ARG A . n 
A 1 2   ALA 2   30  30  ALA ALA A . n 
A 1 3   GLN 3   31  31  GLN GLN A . n 
A 1 4   ASP 4   32  32  ASP ASP A . n 
A 1 5   PHE 5   33  33  PHE PHE A . n 
A 1 6   ILE 6   34  34  ILE ILE A . n 
A 1 7   THR 7   35  35  THR THR A . n 
A 1 8   ILE 8   36  36  ILE ILE A . n 
A 1 9   GLY 9   37  37  GLY GLY A . n 
A 1 10  THR 10  38  38  THR THR A . n 
A 1 11  GLY 11  39  39  GLY GLY A . n 
A 1 12  SER 12  40  40  SER SER A . n 
A 1 13  VAL 13  41  41  VAL VAL A . n 
A 1 14  THR 14  42  42  THR THR A . n 
A 1 15  GLY 15  43  43  GLY GLY A . n 
A 1 16  VAL 16  44  44  VAL VAL A . n 
A 1 17  TYR 17  45  45  TYR TYR A . n 
A 1 18  TYR 18  46  46  TYR TYR A . n 
A 1 19  PRO 19  47  47  PRO PRO A . n 
A 1 20  THR 20  48  48  THR THR A . n 
A 1 21  GLY 21  49  49  GLY GLY A . n 
A 1 22  GLY 22  50  50  GLY GLY A . n 
A 1 23  ALA 23  51  51  ALA ALA A . n 
A 1 24  ILE 24  52  52  ILE ILE A . n 
A 1 25  CYS 25  53  53  CYS CYS A . n 
A 1 26  LYS 26  54  54  LYS LYS A . n 
A 1 27  LEU 27  55  55  LEU LEU A . n 
A 1 28  VAL 28  56  56  VAL VAL A . n 
A 1 29  ASN 29  57  57  ASN ASN A . n 
A 1 30  LYS 30  58  58  LYS LYS A . n 
A 1 31  ASP 31  59  59  ASP ASP A . n 
A 1 32  ARG 32  60  60  ARG ARG A . n 
A 1 33  LYS 33  61  61  LYS LYS A . n 
A 1 34  ASP 34  62  62  ASP ASP A . n 
A 1 35  HIS 35  63  63  HIS HIS A . n 
A 1 36  ASN 36  64  64  ASN ASN A . n 
A 1 37  ILE 37  65  65  ILE ILE A . n 
A 1 38  ARG 38  66  66  ARG ARG A . n 
A 1 39  CYS 39  67  67  CYS CYS A . n 
A 1 40  SER 40  68  68  SER SER A . n 
A 1 41  VAL 41  69  69  VAL VAL A . n 
A 1 42  GLU 42  70  70  GLU GLU A . n 
A 1 43  SER 43  71  71  SER SER A . n 
A 1 44  THR 44  72  72  THR THR A . n 
A 1 45  GLY 45  73  73  GLY GLY A . n 
A 1 46  GLY 46  74  74  GLY GLY A . n 
A 1 47  SER 47  75  75  SER SER A . n 
A 1 48  ILE 48  76  76  ILE ILE A . n 
A 1 49  TYR 49  77  77  TYR TYR A . n 
A 1 50  ASN 50  78  78  ASN ASN A . n 
A 1 51  VAL 51  79  79  VAL VAL A . n 
A 1 52  ASN 52  80  80  ASN ASN A . n 
A 1 53  THR 53  81  81  THR THR A . n 
A 1 54  ILE 54  82  82  ILE ILE A . n 
A 1 55  ARG 55  83  83  ARG ARG A . n 
A 1 56  SER 56  84  84  SER SER A . n 
A 1 57  GLY 57  85  85  GLY GLY A . n 
A 1 58  GLU 58  86  86  GLU GLU A . n 
A 1 59  LEU 59  87  87  LEU LEU A . n 
A 1 60  ASP 60  88  88  ASP ASP A . n 
A 1 61  PHE 61  89  89  PHE PHE A . n 
A 1 62  GLY 62  90  90  GLY GLY A . n 
A 1 63  ILE 63  91  91  ILE ILE A . n 
A 1 64  VAL 64  92  92  VAL VAL A . n 
A 1 65  GLN 65  93  93  GLN GLN A . n 
A 1 66  SER 66  94  94  SER SER A . n 
A 1 67  ASP 67  95  95  ASP ASP A . n 
A 1 68  TRP 68  96  96  TRP TRP A . n 
A 1 69  GLN 69  97  97  GLN GLN A . n 
A 1 70  TYR 70  98  98  TYR TYR A . n 
A 1 71  HIS 71  99  99  HIS HIS A . n 
A 1 72  GLY 72  100 100 GLY GLY A . n 
A 1 73  TYR 73  101 101 TYR TYR A . n 
A 1 74  ASN 74  102 102 ASN ASN A . n 
A 1 75  GLY 75  103 103 GLY GLY A . n 
A 1 76  THR 76  104 104 THR THR A . n 
A 1 77  SER 77  105 105 SER SER A . n 
A 1 78  GLU 78  106 106 GLU GLU A . n 
A 1 79  PHE 79  107 107 PHE PHE A . n 
A 1 80  ALA 80  108 108 ALA ALA A . n 
A 1 81  GLU 81  109 109 GLU GLU A . n 
A 1 82  GLN 82  110 110 GLN GLN A . n 
A 1 83  GLY 83  111 111 GLY GLY A . n 
A 1 84  PRO 84  112 112 PRO PRO A . n 
A 1 85  TYR 85  113 113 TYR TYR A . n 
A 1 86  LYS 86  114 114 LYS LYS A . n 
A 1 87  LYS 87  115 115 LYS LYS A . n 
A 1 88  LEU 88  116 116 LEU LEU A . n 
A 1 89  ARG 89  117 117 ARG ARG A . n 
A 1 90  ALA 90  118 118 ALA ALA A . n 
A 1 91  VAL 91  119 119 VAL VAL A . n 
A 1 92  PHE 92  120 120 PHE PHE A . n 
A 1 93  SER 93  121 121 SER SER A . n 
A 1 94  MET 94  122 122 MET MET A . n 
A 1 95  HIS 95  123 123 HIS HIS A . n 
A 1 96  THR 96  124 124 THR THR A . n 
A 1 97  GLU 97  125 125 GLU GLU A . n 
A 1 98  PRO 98  126 126 PRO PRO A . n 
A 1 99  PHE 99  127 127 PHE PHE A . n 
A 1 100 ASN 100 128 128 ASN ASN A . n 
A 1 101 ILE 101 129 129 ILE ILE A . n 
A 1 102 ILE 102 130 130 ILE ILE A . n 
A 1 103 ALA 103 131 131 ALA ALA A . n 
A 1 104 ARG 104 132 132 ARG ARG A . n 
A 1 105 ALA 105 133 133 ALA ALA A . n 
A 1 106 ASP 106 134 134 ASP ASP A . n 
A 1 107 SER 107 135 135 SER SER A . n 
A 1 108 GLY 108 136 136 GLY GLY A . n 
A 1 109 ILE 109 137 137 ILE ILE A . n 
A 1 110 GLU 110 138 138 GLU GLU A . n 
A 1 111 ASN 111 139 139 ASN ASN A . n 
A 1 112 VAL 112 140 140 VAL VAL A . n 
A 1 113 LYS 113 141 141 LYS LYS A . n 
A 1 114 ASP 114 142 142 ASP ASP A . n 
A 1 115 LEU 115 143 143 LEU LEU A . n 
A 1 116 ALA 116 144 144 ALA ALA A . n 
A 1 117 GLY 117 145 145 GLY GLY A . n 
A 1 118 LYS 118 146 146 LYS LYS A . n 
A 1 119 ARG 119 147 147 ARG ARG A . n 
A 1 120 VAL 120 148 148 VAL VAL A . n 
A 1 121 ASN 121 149 149 ASN ASN A . n 
A 1 122 ILE 122 150 150 ILE ILE A . n 
A 1 123 GLY 123 151 151 GLY GLY A . n 
A 1 124 ASN 124 152 152 ASN ASN A . n 
A 1 125 PRO 125 153 153 PRO PRO A . n 
A 1 126 GLY 126 154 154 GLY GLY A . n 
A 1 127 SER 127 155 155 SER SER A . n 
A 1 128 GLY 128 156 156 GLY GLY A . n 
A 1 129 ASP 129 157 157 ASP ASP A . n 
A 1 130 ARG 130 158 158 ARG ARG A . n 
A 1 131 ALA 131 159 159 ALA ALA A . n 
A 1 132 THR 132 160 160 THR THR A . n 
A 1 133 MET 133 161 161 MET MET A . n 
A 1 134 GLN 134 162 162 GLN GLN A . n 
A 1 135 VAL 135 163 163 VAL VAL A . n 
A 1 136 VAL 136 164 164 VAL VAL A . n 
A 1 137 MET 137 165 165 MET MET A . n 
A 1 138 ASP 138 166 166 ASP ASP A . n 
A 1 139 ALA 139 167 167 ALA ALA A . n 
A 1 140 PHE 140 168 168 PHE PHE A . n 
A 1 141 GLY 141 169 169 GLY GLY A . n 
A 1 142 TRP 142 170 170 TRP TRP A . n 
A 1 143 ASN 143 171 171 ASN ASN A . n 
A 1 144 ASN 144 172 172 ASN ASN A . n 
A 1 145 ASP 145 173 173 ASP ASP A . n 
A 1 146 SER 146 174 174 SER SER A . n 
A 1 147 PHE 147 175 175 PHE PHE A . n 
A 1 148 LYS 148 176 176 LYS LYS A . n 
A 1 149 LEU 149 177 177 LEU LEU A . n 
A 1 150 ALA 150 178 178 ALA ALA A . n 
A 1 151 ALA 151 179 179 ALA ALA A . n 
A 1 152 GLU 152 180 180 GLU GLU A . n 
A 1 153 LEU 153 181 181 LEU LEU A . n 
A 1 154 LYS 154 182 182 LYS LYS A . n 
A 1 155 GLY 155 183 183 GLY GLY A . n 
A 1 156 SER 156 184 184 SER SER A . n 
A 1 157 GLU 157 185 185 GLU GLU A . n 
A 1 158 ARG 158 186 186 ARG ARG A . n 
A 1 159 SER 159 187 187 SER SER A . n 
A 1 160 GLN 160 188 188 GLN GLN A . n 
A 1 161 ALA 161 189 189 ALA ALA A . n 
A 1 162 LEU 162 190 190 LEU LEU A . n 
A 1 163 CYS 163 191 191 CYS CYS A . n 
A 1 164 ASP 164 192 192 ASP ASP A . n 
A 1 165 ASN 165 193 193 ASN ASN A . n 
A 1 166 LYS 166 194 194 LYS LYS A . n 
A 1 167 ILE 167 195 195 ILE ILE A . n 
A 1 168 ASP 168 196 196 ASP ASP A . n 
A 1 169 ALA 169 197 197 ALA ALA A . n 
A 1 170 PHE 170 198 198 PHE PHE A . n 
A 1 171 ILE 171 199 199 ILE ILE A . n 
A 1 172 TYR 172 200 200 TYR TYR A . n 
A 1 173 MET 173 201 201 MET MET A . n 
A 1 174 VAL 174 202 202 VAL VAL A . n 
A 1 175 GLY 175 203 203 GLY GLY A . n 
A 1 176 HIS 176 204 204 HIS HIS A . n 
A 1 177 PRO 177 205 205 PRO PRO A . n 
A 1 178 ASN 178 206 206 ASN ASN A . n 
A 1 179 GLY 179 207 207 GLY GLY A . n 
A 1 180 ALA 180 208 208 ALA ALA A . n 
A 1 181 ILE 181 209 209 ILE ILE A . n 
A 1 182 LYS 182 210 210 LYS LYS A . n 
A 1 183 GLU 183 211 211 GLU GLU A . n 
A 1 184 ALA 184 212 212 ALA ALA A . n 
A 1 185 THR 185 213 213 THR THR A . n 
A 1 186 THR 186 214 214 THR THR A . n 
A 1 187 SER 187 215 215 SER SER A . n 
A 1 188 CYS 188 216 216 CYS CYS A . n 
A 1 189 ALA 189 217 217 ALA ALA A . n 
A 1 190 ALA 190 218 218 ALA ALA A . n 
A 1 191 LYS 191 219 219 LYS LYS A . n 
A 1 192 LEU 192 220 220 LEU LEU A . n 
A 1 193 VAL 193 221 221 VAL VAL A . n 
A 1 194 PRO 194 222 222 PRO PRO A . n 
A 1 195 ALA 195 223 223 ALA ALA A . n 
A 1 196 THR 196 224 224 THR THR A . n 
A 1 197 GLY 197 225 225 GLY GLY A . n 
A 1 198 PRO 198 226 226 PRO PRO A . n 
A 1 199 GLU 199 227 227 GLU GLU A . n 
A 1 200 ILE 200 228 228 ILE ILE A . n 
A 1 201 GLU 201 229 229 GLU GLU A . n 
A 1 202 LYS 202 230 230 LYS LYS A . n 
A 1 203 ILE 203 231 231 ILE ILE A . n 
A 1 204 VAL 204 232 232 VAL VAL A . n 
A 1 205 ALA 205 233 233 ALA ALA A . n 
A 1 206 ASN 206 234 234 ASN ASN A . n 
A 1 207 ASN 207 235 235 ASN ASN A . n 
A 1 208 PRO 208 236 236 PRO PRO A . n 
A 1 209 TYR 209 237 237 TYR TYR A . n 
A 1 210 TYR 210 238 238 TYR TYR A . n 
A 1 211 ALA 211 239 239 ALA ALA A . n 
A 1 212 TYR 212 240 240 TYR TYR A . n 
A 1 213 SER 213 241 241 SER SER A . n 
A 1 214 VAL 214 242 242 VAL VAL A . n 
A 1 215 VAL 215 243 243 VAL VAL A . n 
A 1 216 PRO 216 244 244 PRO PRO A . n 
A 1 217 ALA 217 245 245 ALA ALA A . n 
A 1 218 GLY 218 246 246 GLY GLY A . n 
A 1 219 MET 219 247 247 MET MET A . n 
A 1 220 TYR 220 248 248 TYR TYR A . n 
A 1 221 SER 221 249 249 SER SER A . n 
A 1 222 GLY 222 250 250 GLY GLY A . n 
A 1 223 THR 223 251 251 THR THR A . n 
A 1 224 ASP 224 252 252 ASP ASP A . n 
A 1 225 GLN 225 253 253 GLN GLN A . n 
A 1 226 GLU 226 254 254 GLU GLU A . n 
A 1 227 VAL 227 255 255 VAL VAL A . n 
A 1 228 LYS 228 256 256 LYS LYS A . n 
A 1 229 SER 229 257 257 SER SER A . n 
A 1 230 PHE 230 258 258 PHE PHE A . n 
A 1 231 GLY 231 259 259 GLY GLY A . n 
A 1 232 VAL 232 260 260 VAL VAL A . n 
A 1 233 ALA 233 261 261 ALA ALA A . n 
A 1 234 ALA 234 262 262 ALA ALA A . n 
A 1 235 THR 235 263 263 THR THR A . n 
A 1 236 LEU 236 264 264 LEU LEU A . n 
A 1 237 VAL 237 265 265 VAL VAL A . n 
A 1 238 THR 238 266 266 THR THR A . n 
A 1 239 THR 239 267 267 THR THR A . n 
A 1 240 GLU 240 268 268 GLU GLU A . n 
A 1 241 GLU 241 269 269 GLU GLU A . n 
A 1 242 VAL 242 270 270 VAL VAL A . n 
A 1 243 SER 243 271 271 SER SER A . n 
A 1 244 GLU 244 272 272 GLU GLU A . n 
A 1 245 ALA 245 273 273 ALA ALA A . n 
A 1 246 VAL 246 274 274 VAL VAL A . n 
A 1 247 VAL 247 275 275 VAL VAL A . n 
A 1 248 TYR 248 276 276 TYR TYR A . n 
A 1 249 ASN 249 277 277 ASN ASN A . n 
A 1 250 LEU 250 278 278 LEU LEU A . n 
A 1 251 THR 251 279 279 THR THR A . n 
A 1 252 LYS 252 280 280 LYS LYS A . n 
A 1 253 ALA 253 281 281 ALA ALA A . n 
A 1 254 VAL 254 282 282 VAL VAL A . n 
A 1 255 PHE 255 283 283 PHE PHE A . n 
A 1 256 GLU 256 284 284 GLU GLU A . n 
A 1 257 ASN 257 285 285 ASN ASN A . n 
A 1 258 PHE 258 286 286 PHE PHE A . n 
A 1 259 ASP 259 287 287 ASP ASP A . n 
A 1 260 THR 260 288 288 THR THR A . n 
A 1 261 PHE 261 289 289 PHE PHE A . n 
A 1 262 THR 262 290 290 THR THR A . n 
A 1 263 ARG 263 291 291 ARG ARG A . n 
A 1 264 LEU 264 292 292 LEU LEU A . n 
A 1 265 HIS 265 293 293 HIS HIS A . n 
A 1 266 PRO 266 294 294 PRO PRO A . n 
A 1 267 ALA 267 295 295 ALA ALA A . n 
A 1 268 PHE 268 296 296 PHE PHE A . n 
A 1 269 ALA 269 297 297 ALA ALA A . n 
A 1 270 ASN 270 298 298 ASN ASN A . n 
A 1 271 LEU 271 299 299 LEU LEU A . n 
A 1 272 LYS 272 300 300 LYS LYS A . n 
A 1 273 LYS 273 301 301 LYS LYS A . n 
A 1 274 GLU 274 302 302 GLU GLU A . n 
A 1 275 ASP 275 303 303 ASP ASP A . n 
A 1 276 MET 276 304 304 MET MET A . n 
A 1 277 VAL 277 305 305 VAL VAL A . n 
A 1 278 THR 278 306 306 THR THR A . n 
A 1 279 ALA 279 307 307 ALA ALA A . n 
A 1 280 GLY 280 308 308 GLY GLY A . n 
A 1 281 ASN 281 309 309 ASN ASN A . n 
A 1 282 SER 282 310 310 SER SER A . n 
A 1 283 ILE 283 311 311 ILE ILE A . n 
A 1 284 PRO 284 312 312 PRO PRO A . n 
A 1 285 LEU 285 313 313 LEU LEU A . n 
A 1 286 HIS 286 314 314 HIS HIS A . n 
A 1 287 PRO 287 315 315 PRO PRO A . n 
A 1 288 GLY 288 316 316 GLY GLY A . n 
A 1 289 ALA 289 317 317 ALA ALA A . n 
A 1 290 VAL 290 318 318 VAL VAL A . n 
A 1 291 LYS 291 319 319 LYS LYS A . n 
A 1 292 TYR 292 320 320 TYR TYR A . n 
A 1 293 TYR 293 321 321 TYR TYR A . n 
A 1 294 LYS 294 322 322 LYS LYS A . n 
A 1 295 GLU 295 323 323 GLU GLU A . n 
A 1 296 ALA 296 324 324 ALA ALA A . n 
A 1 297 GLY 297 325 325 GLY GLY A . n 
A 1 298 LEU 298 326 326 LEU LEU A . n 
A 1 299 ILE 299 327 327 ILE ILE A . n 
A 1 300 LYS 300 328 328 LYS LYS A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        GLU 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   GLU 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 GLU 1   401 401 GLU LIG A . 
C 3 NA  1   402 1   NA  NA  A . 
D 3 NA  1   403 2   NA  NA  A . 
E 3 NA  1   404 3   NA  NA  A . 
F 3 NA  1   405 4   NA  NA  A . 
G 3 NA  1   406 5   NA  NA  A . 
H 4 HOH 1   501 188 HOH HOH A . 
H 4 HOH 2   502 392 HOH HOH A . 
H 4 HOH 3   503 219 HOH HOH A . 
H 4 HOH 4   504 327 HOH HOH A . 
H 4 HOH 5   505 29  HOH HOH A . 
H 4 HOH 6   506 83  HOH HOH A . 
H 4 HOH 7   507 155 HOH HOH A . 
H 4 HOH 8   508 144 HOH HOH A . 
H 4 HOH 9   509 409 HOH HOH A . 
H 4 HOH 10  510 30  HOH HOH A . 
H 4 HOH 11  511 59  HOH HOH A . 
H 4 HOH 12  512 50  HOH HOH A . 
H 4 HOH 13  513 92  HOH HOH A . 
H 4 HOH 14  514 357 HOH HOH A . 
H 4 HOH 15  515 241 HOH HOH A . 
H 4 HOH 16  516 82  HOH HOH A . 
H 4 HOH 17  517 8   HOH HOH A . 
H 4 HOH 18  518 171 HOH HOH A . 
H 4 HOH 19  519 316 HOH HOH A . 
H 4 HOH 20  520 215 HOH HOH A . 
H 4 HOH 21  521 221 HOH HOH A . 
H 4 HOH 22  522 11  HOH HOH A . 
H 4 HOH 23  523 330 HOH HOH A . 
H 4 HOH 24  524 130 HOH HOH A . 
H 4 HOH 25  525 246 HOH HOH A . 
H 4 HOH 26  526 251 HOH HOH A . 
H 4 HOH 27  527 393 HOH HOH A . 
H 4 HOH 28  528 58  HOH HOH A . 
H 4 HOH 29  529 91  HOH HOH A . 
H 4 HOH 30  530 63  HOH HOH A . 
H 4 HOH 31  531 231 HOH HOH A . 
H 4 HOH 32  532 37  HOH HOH A . 
H 4 HOH 33  533 99  HOH HOH A . 
H 4 HOH 34  534 118 HOH HOH A . 
H 4 HOH 35  535 80  HOH HOH A . 
H 4 HOH 36  536 209 HOH HOH A . 
H 4 HOH 37  537 277 HOH HOH A . 
H 4 HOH 38  538 4   HOH HOH A . 
H 4 HOH 39  539 97  HOH HOH A . 
H 4 HOH 40  540 75  HOH HOH A . 
H 4 HOH 41  541 62  HOH HOH A . 
H 4 HOH 42  542 44  HOH HOH A . 
H 4 HOH 43  543 266 HOH HOH A . 
H 4 HOH 44  544 107 HOH HOH A . 
H 4 HOH 45  545 180 HOH HOH A . 
H 4 HOH 46  546 55  HOH HOH A . 
H 4 HOH 47  547 2   HOH HOH A . 
H 4 HOH 48  548 65  HOH HOH A . 
H 4 HOH 49  549 178 HOH HOH A . 
H 4 HOH 50  550 7   HOH HOH A . 
H 4 HOH 51  551 27  HOH HOH A . 
H 4 HOH 52  552 110 HOH HOH A . 
H 4 HOH 53  553 6   HOH HOH A . 
H 4 HOH 54  554 211 HOH HOH A . 
H 4 HOH 55  555 194 HOH HOH A . 
H 4 HOH 56  556 19  HOH HOH A . 
H 4 HOH 57  557 290 HOH HOH A . 
H 4 HOH 58  558 64  HOH HOH A . 
H 4 HOH 59  559 26  HOH HOH A . 
H 4 HOH 60  560 42  HOH HOH A . 
H 4 HOH 61  561 252 HOH HOH A . 
H 4 HOH 62  562 106 HOH HOH A . 
H 4 HOH 63  563 41  HOH HOH A . 
H 4 HOH 64  564 39  HOH HOH A . 
H 4 HOH 65  565 225 HOH HOH A . 
H 4 HOH 66  566 47  HOH HOH A . 
H 4 HOH 67  567 38  HOH HOH A . 
H 4 HOH 68  568 152 HOH HOH A . 
H 4 HOH 69  569 48  HOH HOH A . 
H 4 HOH 70  570 98  HOH HOH A . 
H 4 HOH 71  571 94  HOH HOH A . 
H 4 HOH 72  572 407 HOH HOH A . 
H 4 HOH 73  573 166 HOH HOH A . 
H 4 HOH 74  574 230 HOH HOH A . 
H 4 HOH 75  575 163 HOH HOH A . 
H 4 HOH 76  576 69  HOH HOH A . 
H 4 HOH 77  577 12  HOH HOH A . 
H 4 HOH 78  578 125 HOH HOH A . 
H 4 HOH 79  579 28  HOH HOH A . 
H 4 HOH 80  580 3   HOH HOH A . 
H 4 HOH 81  581 61  HOH HOH A . 
H 4 HOH 82  582 52  HOH HOH A . 
H 4 HOH 83  583 57  HOH HOH A . 
H 4 HOH 84  584 340 HOH HOH A . 
H 4 HOH 85  585 68  HOH HOH A . 
H 4 HOH 86  586 191 HOH HOH A . 
H 4 HOH 87  587 150 HOH HOH A . 
H 4 HOH 88  588 93  HOH HOH A . 
H 4 HOH 89  589 53  HOH HOH A . 
H 4 HOH 90  590 143 HOH HOH A . 
H 4 HOH 91  591 154 HOH HOH A . 
H 4 HOH 92  592 60  HOH HOH A . 
H 4 HOH 93  593 256 HOH HOH A . 
H 4 HOH 94  594 34  HOH HOH A . 
H 4 HOH 95  595 5   HOH HOH A . 
H 4 HOH 96  596 46  HOH HOH A . 
H 4 HOH 97  597 164 HOH HOH A . 
H 4 HOH 98  598 56  HOH HOH A . 
H 4 HOH 99  599 70  HOH HOH A . 
H 4 HOH 100 600 100 HOH HOH A . 
H 4 HOH 101 601 21  HOH HOH A . 
H 4 HOH 102 602 45  HOH HOH A . 
H 4 HOH 103 603 16  HOH HOH A . 
H 4 HOH 104 604 13  HOH HOH A . 
H 4 HOH 105 605 168 HOH HOH A . 
H 4 HOH 106 606 113 HOH HOH A . 
H 4 HOH 107 607 54  HOH HOH A . 
H 4 HOH 108 608 31  HOH HOH A . 
H 4 HOH 109 609 77  HOH HOH A . 
H 4 HOH 110 610 174 HOH HOH A . 
H 4 HOH 111 611 335 HOH HOH A . 
H 4 HOH 112 612 76  HOH HOH A . 
H 4 HOH 113 613 242 HOH HOH A . 
H 4 HOH 114 614 17  HOH HOH A . 
H 4 HOH 115 615 224 HOH HOH A . 
H 4 HOH 116 616 294 HOH HOH A . 
H 4 HOH 117 617 109 HOH HOH A . 
H 4 HOH 118 618 116 HOH HOH A . 
H 4 HOH 119 619 395 HOH HOH A . 
H 4 HOH 120 620 203 HOH HOH A . 
H 4 HOH 121 621 259 HOH HOH A . 
H 4 HOH 122 622 89  HOH HOH A . 
H 4 HOH 123 623 79  HOH HOH A . 
H 4 HOH 124 624 96  HOH HOH A . 
H 4 HOH 125 625 193 HOH HOH A . 
H 4 HOH 126 626 24  HOH HOH A . 
H 4 HOH 127 627 218 HOH HOH A . 
H 4 HOH 128 628 300 HOH HOH A . 
H 4 HOH 129 629 353 HOH HOH A . 
H 4 HOH 130 630 232 HOH HOH A . 
H 4 HOH 131 631 196 HOH HOH A . 
H 4 HOH 132 632 119 HOH HOH A . 
H 4 HOH 133 633 189 HOH HOH A . 
H 4 HOH 134 634 73  HOH HOH A . 
H 4 HOH 135 635 183 HOH HOH A . 
H 4 HOH 136 636 245 HOH HOH A . 
H 4 HOH 137 637 184 HOH HOH A . 
H 4 HOH 138 638 72  HOH HOH A . 
H 4 HOH 139 639 14  HOH HOH A . 
H 4 HOH 140 640 287 HOH HOH A . 
H 4 HOH 141 641 40  HOH HOH A . 
H 4 HOH 142 642 9   HOH HOH A . 
H 4 HOH 143 643 15  HOH HOH A . 
H 4 HOH 144 644 18  HOH HOH A . 
H 4 HOH 145 645 140 HOH HOH A . 
H 4 HOH 146 646 226 HOH HOH A . 
H 4 HOH 147 647 298 HOH HOH A . 
H 4 HOH 148 648 187 HOH HOH A . 
H 4 HOH 149 649 10  HOH HOH A . 
H 4 HOH 150 650 206 HOH HOH A . 
H 4 HOH 151 651 20  HOH HOH A . 
H 4 HOH 152 652 85  HOH HOH A . 
H 4 HOH 153 653 104 HOH HOH A . 
H 4 HOH 154 654 35  HOH HOH A . 
H 4 HOH 155 655 272 HOH HOH A . 
H 4 HOH 156 656 157 HOH HOH A . 
H 4 HOH 157 657 22  HOH HOH A . 
H 4 HOH 158 658 394 HOH HOH A . 
H 4 HOH 159 659 153 HOH HOH A . 
H 4 HOH 160 660 361 HOH HOH A . 
H 4 HOH 161 661 313 HOH HOH A . 
H 4 HOH 162 662 84  HOH HOH A . 
H 4 HOH 163 663 86  HOH HOH A . 
H 4 HOH 164 664 240 HOH HOH A . 
H 4 HOH 165 665 135 HOH HOH A . 
H 4 HOH 166 666 95  HOH HOH A . 
H 4 HOH 167 667 148 HOH HOH A . 
H 4 HOH 168 668 312 HOH HOH A . 
H 4 HOH 169 669 1   HOH HOH A . 
H 4 HOH 170 670 198 HOH HOH A . 
H 4 HOH 171 671 88  HOH HOH A . 
H 4 HOH 172 672 223 HOH HOH A . 
H 4 HOH 173 673 234 HOH HOH A . 
H 4 HOH 174 674 261 HOH HOH A . 
H 4 HOH 175 675 186 HOH HOH A . 
H 4 HOH 176 676 169 HOH HOH A . 
H 4 HOH 177 677 289 HOH HOH A . 
H 4 HOH 178 678 33  HOH HOH A . 
H 4 HOH 179 679 36  HOH HOH A . 
H 4 HOH 180 680 78  HOH HOH A . 
H 4 HOH 181 681 271 HOH HOH A . 
H 4 HOH 182 682 190 HOH HOH A . 
H 4 HOH 183 683 250 HOH HOH A . 
H 4 HOH 184 684 285 HOH HOH A . 
H 4 HOH 185 685 90  HOH HOH A . 
H 4 HOH 186 686 172 HOH HOH A . 
H 4 HOH 187 687 255 HOH HOH A . 
H 4 HOH 188 688 279 HOH HOH A . 
H 4 HOH 189 689 292 HOH HOH A . 
H 4 HOH 190 690 339 HOH HOH A . 
H 4 HOH 191 691 185 HOH HOH A . 
H 4 HOH 192 692 71  HOH HOH A . 
H 4 HOH 193 693 201 HOH HOH A . 
H 4 HOH 194 694 307 HOH HOH A . 
H 4 HOH 195 695 299 HOH HOH A . 
H 4 HOH 196 696 364 HOH HOH A . 
H 4 HOH 197 697 87  HOH HOH A . 
H 4 HOH 198 698 170 HOH HOH A . 
H 4 HOH 199 699 239 HOH HOH A . 
H 4 HOH 200 700 32  HOH HOH A . 
H 4 HOH 201 701 396 HOH HOH A . 
H 4 HOH 202 702 126 HOH HOH A . 
H 4 HOH 203 703 81  HOH HOH A . 
H 4 HOH 204 704 217 HOH HOH A . 
H 4 HOH 205 705 388 HOH HOH A . 
H 4 HOH 206 706 123 HOH HOH A . 
H 4 HOH 207 707 404 HOH HOH A . 
H 4 HOH 208 708 275 HOH HOH A . 
H 4 HOH 209 709 253 HOH HOH A . 
H 4 HOH 210 710 381 HOH HOH A . 
H 4 HOH 211 711 235 HOH HOH A . 
H 4 HOH 212 712 297 HOH HOH A . 
H 4 HOH 213 713 248 HOH HOH A . 
H 4 HOH 214 714 274 HOH HOH A . 
H 4 HOH 215 715 267 HOH HOH A . 
H 4 HOH 216 716 147 HOH HOH A . 
H 4 HOH 217 717 167 HOH HOH A . 
H 4 HOH 218 718 216 HOH HOH A . 
H 4 HOH 219 719 314 HOH HOH A . 
H 4 HOH 220 720 257 HOH HOH A . 
H 4 HOH 221 721 389 HOH HOH A . 
H 4 HOH 222 722 67  HOH HOH A . 
H 4 HOH 223 723 124 HOH HOH A . 
H 4 HOH 224 724 238 HOH HOH A . 
H 4 HOH 225 725 102 HOH HOH A . 
H 4 HOH 226 726 371 HOH HOH A . 
H 4 HOH 227 727 101 HOH HOH A . 
H 4 HOH 228 728 162 HOH HOH A . 
H 4 HOH 229 729 383 HOH HOH A . 
H 4 HOH 230 730 23  HOH HOH A . 
H 4 HOH 231 731 280 HOH HOH A . 
H 4 HOH 232 732 366 HOH HOH A . 
H 4 HOH 233 733 303 HOH HOH A . 
H 4 HOH 234 734 263 HOH HOH A . 
H 4 HOH 235 735 243 HOH HOH A . 
H 4 HOH 236 736 363 HOH HOH A . 
H 4 HOH 237 737 165 HOH HOH A . 
H 4 HOH 238 738 49  HOH HOH A . 
H 4 HOH 239 739 128 HOH HOH A . 
H 4 HOH 240 740 379 HOH HOH A . 
H 4 HOH 241 741 308 HOH HOH A . 
H 4 HOH 242 742 338 HOH HOH A . 
H 4 HOH 243 743 346 HOH HOH A . 
H 4 HOH 244 744 228 HOH HOH A . 
H 4 HOH 245 745 318 HOH HOH A . 
H 4 HOH 246 746 237 HOH HOH A . 
H 4 HOH 247 747 208 HOH HOH A . 
H 4 HOH 248 748 159 HOH HOH A . 
H 4 HOH 249 749 181 HOH HOH A . 
H 4 HOH 250 750 351 HOH HOH A . 
H 4 HOH 251 751 360 HOH HOH A . 
H 4 HOH 252 752 276 HOH HOH A . 
H 4 HOH 253 753 291 HOH HOH A . 
H 4 HOH 254 754 160 HOH HOH A . 
H 4 HOH 255 755 382 HOH HOH A . 
H 4 HOH 256 756 278 HOH HOH A . 
H 4 HOH 257 757 202 HOH HOH A . 
H 4 HOH 258 758 273 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A GLU 109 ? CG  ? A GLU 81 CG  
2 1 Y 1 A GLU 109 ? CD  ? A GLU 81 CD  
3 1 Y 1 A GLU 109 ? OE1 ? A GLU 81 OE1 
4 1 Y 1 A GLU 109 ? OE2 ? A GLU 81 OE2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.20.1_4487 1 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.20.1_4487 2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? xia2   ? ? ? .           3 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? xia2   ? ? ? .           4 
? phasing          ? ? ? ? ? ? ? ? ? ? ? DIMPLE ? ? ? v2.6.2      5 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8S4J 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     126.660 
_cell.length_a_esd                 ? 
_cell.length_b                     126.660 
_cell.length_b_esd                 ? 
_cell.length_c                     180.280 
_cell.length_c_esd                 ? 
_cell.volume                       2504708.263 
_cell.volume_esd                   ? 
_cell.Z_PDB                        18 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8S4J 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                155 
_symmetry.space_group_name_Hall            
;R 3 2"
;
_symmetry.space_group_name_H-M             'H 3 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8S4J 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             ? 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          ? 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.0 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '2.4 M sodium malonate' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            298 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-10-19 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.9537 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'DIAMOND BEAMLINE I04' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        '0.9537 Angstroms' 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   I04 
_diffrn_source.pdbx_synchrotron_site       Diamond 
# 
_reflns.B_iso_Wilson_estimate                          27.60 
_reflns.entry_id                                       8S4J 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.7 
_reflns.d_resolution_low                               69.64 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     61144 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.99 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                20.5 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          26.31 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.0658 
_reflns.pdbx_Rpim_I_all                                0.01456 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   1 
_reflns.pdbx_CC_star                                   1 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.06415 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.7 
_reflns_shell.d_res_low                                     1.761 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           3.42 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             6061 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               0.2063 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.917 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.9057 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               28.09 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8S4J 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.70 
_refine.ls_d_res_low                             69.64 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     61140 
_refine.ls_number_reflns_R_free                  3035 
_refine.ls_number_reflns_R_work                  58105 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.99 
_refine.ls_percent_reflns_R_free                 4.96 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1914 
_refine.ls_R_factor_R_free                       0.2136 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1902 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.35 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 21.7765 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2557 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.70 
_refine_hist.d_res_low                        69.64 
_refine_hist.number_atoms_solvent             258 
_refine_hist.number_atoms_total               2559 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2286 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         15 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0068 ? 2503 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.9639 ? 3425 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0624 ? 379  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0063 ? 455  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 6.0741 ? 375  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.70 1.73  . . 147 2604 99.96  . . . . 0.3927 . . . . . . . . . . . 0.3923 
'X-RAY DIFFRACTION' 1.73 1.75  . . 144 2627 100.00 . . . . 0.3434 . . . . . . . . . . . 0.3259 
'X-RAY DIFFRACTION' 1.75 1.79  . . 129 2610 100.00 . . . . 0.3060 . . . . . . . . . . . 0.3407 
'X-RAY DIFFRACTION' 1.79 1.82  . . 119 2624 100.00 . . . . 0.2715 . . . . . . . . . . . 0.3045 
'X-RAY DIFFRACTION' 1.82 1.85  . . 132 2651 100.00 . . . . 0.2588 . . . . . . . . . . . 0.2759 
'X-RAY DIFFRACTION' 1.85 1.89  . . 136 2620 100.00 . . . . 0.2324 . . . . . . . . . . . 0.2814 
'X-RAY DIFFRACTION' 1.89 1.93  . . 144 2633 100.00 . . . . 0.2288 . . . . . . . . . . . 0.2694 
'X-RAY DIFFRACTION' 1.93 1.98  . . 128 2615 100.00 . . . . 0.2188 . . . . . . . . . . . 0.2637 
'X-RAY DIFFRACTION' 1.98 2.03  . . 142 2599 100.00 . . . . 0.2116 . . . . . . . . . . . 0.2661 
'X-RAY DIFFRACTION' 2.03 2.08  . . 129 2634 100.00 . . . . 0.2175 . . . . . . . . . . . 0.2211 
'X-RAY DIFFRACTION' 2.08 2.14  . . 137 2623 100.00 . . . . 0.2263 . . . . . . . . . . . 0.2452 
'X-RAY DIFFRACTION' 2.14 2.21  . . 152 2626 99.96  . . . . 0.2378 . . . . . . . . . . . 0.2702 
'X-RAY DIFFRACTION' 2.21 2.29  . . 156 2606 100.00 . . . . 0.2018 . . . . . . . . . . . 0.2267 
'X-RAY DIFFRACTION' 2.29 2.38  . . 129 2636 100.00 . . . . 0.1974 . . . . . . . . . . . 0.2176 
'X-RAY DIFFRACTION' 2.38 2.49  . . 155 2633 100.00 . . . . 0.2035 . . . . . . . . . . . 0.2126 
'X-RAY DIFFRACTION' 2.49 2.62  . . 149 2629 100.00 . . . . 0.2121 . . . . . . . . . . . 0.2369 
'X-RAY DIFFRACTION' 2.62 2.79  . . 136 2656 100.00 . . . . 0.2183 . . . . . . . . . . . 0.2362 
'X-RAY DIFFRACTION' 2.79 3.00  . . 146 2631 100.00 . . . . 0.2156 . . . . . . . . . . . 0.2504 
'X-RAY DIFFRACTION' 3.00 3.30  . . 123 2674 100.00 . . . . 0.1861 . . . . . . . . . . . 0.2179 
'X-RAY DIFFRACTION' 3.30 3.78  . . 132 2684 100.00 . . . . 0.1556 . . . . . . . . . . . 0.1792 
'X-RAY DIFFRACTION' 3.78 4.76  . . 131 2701 100.00 . . . . 0.1250 . . . . . . . . . . . 0.1291 
'X-RAY DIFFRACTION' 4.76 69.64 . . 139 2789 99.86  . . . . 0.1580 . . . . . . . . . . . 0.1714 
# 
_struct.entry_id                     8S4J 
_struct.title                        
;Structure, substrate selectivity determinants and membrane interactions of a Glutamate-specific TAXI TRAP binding protein from Vibrio cholerae.
;
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8S4J 
_struct_keywords.text            'Substrate binding protein TAXI-TRAP Glutamate Periplasmic, TRANSPORT PROTEIN' 
_struct_keywords.pdbx_keywords   'TRANSPORT PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 3 ? 
E N N 3 ? 
F N N 3 ? 
G N N 3 ? 
H N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    A0A0H6LKE4_VIBCL 
_struct_ref.pdbx_db_accession          A0A0H6LKE4 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;AQDFITIGTGSVTGVYYPTGGAICKLVNKDRKDHNIRCSVESTGGSIYNVNTIRSGELDFGIVQSDWQYHGYNGTSEFAE
QGPYKKLRAVFSMHTEPFNIIARADSGIENVKDLAGKRVNIGNPGSGDRATMQVVMDAFGWNNDSFKLAAELKGSERSQA
LCDNKIDAFIYMVGHPNGAIKEATTSCAAKLVPATGPEIEKIVANNPYYAYSVVPAGMYSGTDQEVKSFGVAATLVTTEE
VSEAVVYNLTKAVFENFDTFTRLHPAFANLKKEDMVTAGNSIPLHPGAVKYYKEAGLIK
;
_struct_ref.pdbx_align_begin           30 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8S4J 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 2 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 300 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             A0A0H6LKE4 
_struct_ref_seq.db_align_beg                  30 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  328 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       30 
_struct_ref_seq.pdbx_auth_seq_align_end       328 
# 
_struct_ref_seq_dif.align_id                     1 
_struct_ref_seq_dif.pdbx_pdb_id_code             8S4J 
_struct_ref_seq_dif.mon_id                       ARG 
_struct_ref_seq_dif.pdbx_pdb_strand_id           A 
_struct_ref_seq_dif.seq_num                      1 
_struct_ref_seq_dif.pdbx_pdb_ins_code            ? 
_struct_ref_seq_dif.pdbx_seq_db_name             UNP 
_struct_ref_seq_dif.pdbx_seq_db_accession_code   A0A0H6LKE4 
_struct_ref_seq_dif.db_mon_id                    ? 
_struct_ref_seq_dif.pdbx_seq_db_seq_num          ? 
_struct_ref_seq_dif.details                      'expression tag' 
_struct_ref_seq_dif.pdbx_auth_seq_num            29 
_struct_ref_seq_dif.pdbx_ordinal                 1 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 540   ? 
1 MORE         -35   ? 
1 'SSA (A^2)'  12210 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 VAL A 16  ? LYS A 30  ? VAL A 44  LYS A 58  1 ? 15 
HELX_P HELX_P2  AA2 ASP A 31  ? ASN A 36  ? ASP A 59  ASN A 64  1 ? 6  
HELX_P HELX_P3  AA3 GLY A 46  ? SER A 56  ? GLY A 74  SER A 84  1 ? 11 
HELX_P HELX_P4  AA4 SER A 66  ? GLY A 75  ? SER A 94  GLY A 103 1 ? 10 
HELX_P HELX_P5  AA5 THR A 76  ? ALA A 80  ? THR A 104 ALA A 108 5 ? 5  
HELX_P HELX_P6  AA6 ASN A 111 ? ALA A 116 ? ASN A 139 ALA A 144 5 ? 6  
HELX_P HELX_P7  AA7 SER A 127 ? GLY A 141 ? SER A 155 GLY A 169 1 ? 15 
HELX_P HELX_P8  AA8 ASN A 143 ? PHE A 147 ? ASN A 171 PHE A 175 5 ? 5  
HELX_P HELX_P9  AA9 LYS A 154 ? SER A 156 ? LYS A 182 SER A 184 5 ? 3  
HELX_P HELX_P10 AB1 GLU A 157 ? LEU A 162 ? GLU A 185 LEU A 190 1 ? 6  
HELX_P HELX_P11 AB2 ASN A 178 ? ALA A 189 ? ASN A 206 ALA A 217 1 ? 12 
HELX_P HELX_P12 AB3 GLY A 197 ? ASN A 207 ? GLY A 225 ASN A 235 1 ? 11 
HELX_P HELX_P13 AB4 SER A 243 ? GLU A 256 ? SER A 271 GLU A 284 1 ? 14 
HELX_P HELX_P14 AB5 ASN A 257 ? THR A 262 ? ASN A 285 THR A 290 1 ? 6  
HELX_P HELX_P15 AB6 ARG A 263 ? LEU A 264 ? ARG A 291 LEU A 292 5 ? 2  
HELX_P HELX_P16 AB7 HIS A 265 ? ALA A 269 ? HIS A 293 ALA A 297 5 ? 5  
HELX_P HELX_P17 AB8 LYS A 272 ? ALA A 279 ? LYS A 300 ALA A 307 1 ? 8  
HELX_P HELX_P18 AB9 HIS A 286 ? ALA A 296 ? HIS A 314 ALA A 324 1 ? 11 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1  disulf ? ? A CYS 25  SG  ? ? ? 1_555 A CYS 39 SG ? ? A CYS 53  A CYS 67  1_555  ? ? ? ? ? ? ? 2.052 ? ? 
metalc1  metalc ? ? A GLU 78  OE1 ? ? ? 1_555 E NA  .  NA ? ? A GLU 106 A NA  404 1_555  ? ? ? ? ? ? ? 2.285 ? ? 
metalc2  metalc ? ? A VAL 204 O   ? ? ? 1_555 C NA  .  NA ? ? A VAL 232 A NA  402 1_555  ? ? ? ? ? ? ? 2.282 ? ? 
metalc3  metalc ? ? A ASN 207 O   ? ? ? 1_555 C NA  .  NA ? ? A ASN 235 A NA  402 1_555  ? ? ? ? ? ? ? 2.306 ? ? 
metalc4  metalc ? ? A TYR 210 O   ? ? ? 1_555 C NA  .  NA ? ? A TYR 238 A NA  402 1_555  ? ? ? ? ? ? ? 2.307 ? ? 
metalc5  metalc ? ? A ASN 270 OD1 ? ? ? 1_555 G NA  .  NA ? ? A ASN 298 A NA  406 11_445 ? ? ? ? ? ? ? 2.383 ? ? 
metalc6  metalc ? ? A THR 278 O   ? ? ? 1_555 D NA  .  NA ? ? A THR 306 A NA  403 1_555  ? ? ? ? ? ? ? 2.421 ? ? 
metalc7  metalc ? ? A ASN 281 O   ? ? ? 1_555 D NA  .  NA ? ? A ASN 309 A NA  403 1_555  ? ? ? ? ? ? ? 2.368 ? ? 
metalc8  metalc ? ? C NA  .   NA  ? ? ? 1_555 H HOH .  O  ? ? A NA  402 A HOH 678 1_555  ? ? ? ? ? ? ? 2.371 ? ? 
metalc9  metalc ? ? C NA  .   NA  ? ? ? 1_555 H HOH .  O  ? ? A NA  402 A HOH 700 1_555  ? ? ? ? ? ? ? 2.307 ? ? 
metalc10 metalc ? ? D NA  .   NA  ? ? ? 1_555 H HOH .  O  ? ? A NA  403 A HOH 698 1_555  ? ? ? ? ? ? ? 2.350 ? ? 
metalc11 metalc ? ? D NA  .   NA  ? ? ? 1_555 H HOH .  O  ? ? A NA  403 A HOH 702 1_555  ? ? ? ? ? ? ? 2.339 ? ? 
metalc12 metalc ? ? D NA  .   NA  ? ? ? 1_555 H HOH .  O  ? ? A NA  403 A HOH 716 1_555  ? ? ? ? ? ? ? 2.517 ? ? 
metalc13 metalc ? ? D NA  .   NA  ? ? ? 1_555 H HOH .  O  ? ? A NA  403 A HOH 717 1_555  ? ? ? ? ? ? ? 2.421 ? ? 
metalc14 metalc ? ? E NA  .   NA  ? ? ? 1_555 H HOH .  O  ? ? A NA  404 A HOH 614 1_555  ? ? ? ? ? ? ? 2.529 ? ? 
metalc15 metalc ? ? E NA  .   NA  ? ? ? 1_555 H HOH .  O  ? ? A NA  404 A HOH 688 1_555  ? ? ? ? ? ? ? 3.147 ? ? 
metalc16 metalc ? ? E NA  .   NA  ? ? ? 1_555 H HOH .  O  ? ? A NA  404 A HOH 703 1_555  ? ? ? ? ? ? ? 3.160 ? ? 
metalc17 metalc ? ? F NA  .   NA  ? ? ? 1_555 H HOH .  O  ? ? A NA  405 A HOH 713 1_555  ? ? ? ? ? ? ? 3.164 ? ? 
metalc18 metalc ? ? G NA  .   NA  ? ? ? 1_555 H HOH .  O  ? ? A NA  406 A HOH 567 1_555  ? ? ? ? ? ? ? 2.599 ? ? 
metalc19 metalc ? ? G NA  .   NA  ? ? ? 1_555 H HOH .  O  ? ? A NA  406 A HOH 574 1_555  ? ? ? ? ? ? ? 2.308 ? ? 
metalc20 metalc ? ? G NA  .   NA  ? ? ? 1_555 H HOH .  O  ? ? A NA  406 A HOH 587 1_555  ? ? ? ? ? ? ? 2.503 ? ? 
metalc21 metalc ? ? G NA  .   NA  ? ? ? 1_555 H HOH .  O  ? ? A NA  406 A HOH 690 1_555  ? ? ? ? ? ? ? 2.371 ? ? 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
metalc ? ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  OE1 ? A GLU 78  ? A GLU 106 ? 1_555 NA ? E NA . ? A NA 404 ? 1_555  O ? H HOH .   ? A HOH 614 ? 1_555 135.3 ? 
2  OE1 ? A GLU 78  ? A GLU 106 ? 1_555 NA ? E NA . ? A NA 404 ? 1_555  O ? H HOH .   ? A HOH 688 ? 1_555 109.7 ? 
3  O   ? H HOH .   ? A HOH 614 ? 1_555 NA ? E NA . ? A NA 404 ? 1_555  O ? H HOH .   ? A HOH 688 ? 1_555 115.0 ? 
4  OE1 ? A GLU 78  ? A GLU 106 ? 1_555 NA ? E NA . ? A NA 404 ? 1_555  O ? H HOH .   ? A HOH 703 ? 1_555 72.2  ? 
5  O   ? H HOH .   ? A HOH 614 ? 1_555 NA ? E NA . ? A NA 404 ? 1_555  O ? H HOH .   ? A HOH 703 ? 1_555 117.9 ? 
6  O   ? H HOH .   ? A HOH 688 ? 1_555 NA ? E NA . ? A NA 404 ? 1_555  O ? H HOH .   ? A HOH 703 ? 1_555 74.7  ? 
7  O   ? A VAL 204 ? A VAL 232 ? 1_555 NA ? C NA . ? A NA 402 ? 1_555  O ? A ASN 207 ? A ASN 235 ? 1_555 90.6  ? 
8  O   ? A VAL 204 ? A VAL 232 ? 1_555 NA ? C NA . ? A NA 402 ? 1_555  O ? A TYR 210 ? A TYR 238 ? 1_555 99.5  ? 
9  O   ? A ASN 207 ? A ASN 235 ? 1_555 NA ? C NA . ? A NA 402 ? 1_555  O ? A TYR 210 ? A TYR 238 ? 1_555 96.9  ? 
10 O   ? A VAL 204 ? A VAL 232 ? 1_555 NA ? C NA . ? A NA 402 ? 1_555  O ? H HOH .   ? A HOH 678 ? 1_555 166.8 ? 
11 O   ? A ASN 207 ? A ASN 235 ? 1_555 NA ? C NA . ? A NA 402 ? 1_555  O ? H HOH .   ? A HOH 678 ? 1_555 102.1 ? 
12 O   ? A TYR 210 ? A TYR 238 ? 1_555 NA ? C NA . ? A NA 402 ? 1_555  O ? H HOH .   ? A HOH 678 ? 1_555 82.7  ? 
13 O   ? A VAL 204 ? A VAL 232 ? 1_555 NA ? C NA . ? A NA 402 ? 1_555  O ? H HOH .   ? A HOH 700 ? 1_555 90.5  ? 
14 O   ? A ASN 207 ? A ASN 235 ? 1_555 NA ? C NA . ? A NA 402 ? 1_555  O ? H HOH .   ? A HOH 700 ? 1_555 109.7 ? 
15 O   ? A TYR 210 ? A TYR 238 ? 1_555 NA ? C NA . ? A NA 402 ? 1_555  O ? H HOH .   ? A HOH 700 ? 1_555 151.5 ? 
16 O   ? H HOH .   ? A HOH 678 ? 1_555 NA ? C NA . ? A NA 402 ? 1_555  O ? H HOH .   ? A HOH 700 ? 1_555 82.0  ? 
17 OD1 ? A ASN 270 ? A ASN 298 ? 1_555 NA ? G NA . ? A NA 406 ? 11_445 O ? H HOH .   ? A HOH 567 ? 1_555 76.6  ? 
18 OD1 ? A ASN 270 ? A ASN 298 ? 1_555 NA ? G NA . ? A NA 406 ? 11_445 O ? H HOH .   ? A HOH 574 ? 1_555 60.4  ? 
19 O   ? H HOH .   ? A HOH 567 ? 1_555 NA ? G NA . ? A NA 406 ? 11_445 O ? H HOH .   ? A HOH 574 ? 1_555 20.3  ? 
20 OD1 ? A ASN 270 ? A ASN 298 ? 1_555 NA ? G NA . ? A NA 406 ? 11_445 O ? H HOH .   ? A HOH 587 ? 1_555 70.7  ? 
21 O   ? H HOH .   ? A HOH 567 ? 1_555 NA ? G NA . ? A NA 406 ? 11_445 O ? H HOH .   ? A HOH 587 ? 1_555 6.2   ? 
22 O   ? H HOH .   ? A HOH 574 ? 1_555 NA ? G NA . ? A NA 406 ? 11_445 O ? H HOH .   ? A HOH 587 ? 1_555 17.3  ? 
23 OD1 ? A ASN 270 ? A ASN 298 ? 1_555 NA ? G NA . ? A NA 406 ? 11_445 O ? H HOH .   ? A HOH 690 ? 1_555 78.8  ? 
24 O   ? H HOH .   ? A HOH 567 ? 1_555 NA ? G NA . ? A NA 406 ? 11_445 O ? H HOH .   ? A HOH 690 ? 1_555 20.2  ? 
25 O   ? H HOH .   ? A HOH 574 ? 1_555 NA ? G NA . ? A NA 406 ? 11_445 O ? H HOH .   ? A HOH 690 ? 1_555 19.6  ? 
26 O   ? H HOH .   ? A HOH 587 ? 1_555 NA ? G NA . ? A NA 406 ? 11_445 O ? H HOH .   ? A HOH 690 ? 1_555 23.3  ? 
27 O   ? A THR 278 ? A THR 306 ? 1_555 NA ? D NA . ? A NA 403 ? 1_555  O ? A ASN 281 ? A ASN 309 ? 1_555 94.4  ? 
28 O   ? A THR 278 ? A THR 306 ? 1_555 NA ? D NA . ? A NA 403 ? 1_555  O ? H HOH .   ? A HOH 698 ? 1_555 175.5 ? 
29 O   ? A ASN 281 ? A ASN 309 ? 1_555 NA ? D NA . ? A NA 403 ? 1_555  O ? H HOH .   ? A HOH 698 ? 1_555 84.5  ? 
30 O   ? A THR 278 ? A THR 306 ? 1_555 NA ? D NA . ? A NA 403 ? 1_555  O ? H HOH .   ? A HOH 702 ? 1_555 91.3  ? 
31 O   ? A ASN 281 ? A ASN 309 ? 1_555 NA ? D NA . ? A NA 403 ? 1_555  O ? H HOH .   ? A HOH 702 ? 1_555 88.0  ? 
32 O   ? H HOH .   ? A HOH 698 ? 1_555 NA ? D NA . ? A NA 403 ? 1_555  O ? H HOH .   ? A HOH 702 ? 1_555 84.3  ? 
33 O   ? A THR 278 ? A THR 306 ? 1_555 NA ? D NA . ? A NA 403 ? 1_555  O ? H HOH .   ? A HOH 716 ? 1_555 92.0  ? 
34 O   ? A ASN 281 ? A ASN 309 ? 1_555 NA ? D NA . ? A NA 403 ? 1_555  O ? H HOH .   ? A HOH 716 ? 1_555 92.7  ? 
35 O   ? H HOH .   ? A HOH 698 ? 1_555 NA ? D NA . ? A NA 403 ? 1_555  O ? H HOH .   ? A HOH 716 ? 1_555 92.4  ? 
36 O   ? H HOH .   ? A HOH 702 ? 1_555 NA ? D NA . ? A NA 403 ? 1_555  O ? H HOH .   ? A HOH 716 ? 1_555 176.5 ? 
37 O   ? A THR 278 ? A THR 306 ? 1_555 NA ? D NA . ? A NA 403 ? 1_555  O ? H HOH .   ? A HOH 717 ? 1_555 92.7  ? 
38 O   ? A ASN 281 ? A ASN 309 ? 1_555 NA ? D NA . ? A NA 403 ? 1_555  O ? H HOH .   ? A HOH 717 ? 1_555 167.5 ? 
39 O   ? H HOH .   ? A HOH 698 ? 1_555 NA ? D NA . ? A NA 403 ? 1_555  O ? H HOH .   ? A HOH 717 ? 1_555 89.2  ? 
40 O   ? H HOH .   ? A HOH 702 ? 1_555 NA ? D NA . ? A NA 403 ? 1_555  O ? H HOH .   ? A HOH 717 ? 1_555 102.1 ? 
41 O   ? H HOH .   ? A HOH 716 ? 1_555 NA ? D NA . ? A NA 403 ? 1_555  O ? H HOH .   ? A HOH 717 ? 1_555 76.7  ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      CYS 
_pdbx_modification_feature.label_asym_id                      A 
_pdbx_modification_feature.label_seq_id                       25 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      39 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       CYS 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        53 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      A 
_pdbx_modification_feature.modified_residue_auth_seq_id       67 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               SG 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                . 
_pdbx_modification_feature.ref_pcm_id                         . 
_pdbx_modification_feature.ref_comp_id                        . 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Disulfide bridge' 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          HIS 
_struct_mon_prot_cis.label_seq_id           176 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           HIS 
_struct_mon_prot_cis.auth_seq_id            204 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    177 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     205 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       -7.77 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 6 ? 
AA2 ? 6 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? parallel      
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? parallel      
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA2 5 6 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ARG A 38  ? GLU A 42  ? ARG A 66  GLU A 70  
AA1 2 PHE A 5   ? GLY A 9   ? PHE A 33  GLY A 37  
AA1 3 PHE A 61  ? GLN A 65  ? PHE A 89  GLN A 93  
AA1 4 VAL A 227 ? THR A 239 ? VAL A 255 THR A 267 
AA1 5 LEU A 88  ? ALA A 103 ? LEU A 116 ALA A 131 
AA1 6 LYS A 191 ? VAL A 193 ? LYS A 219 VAL A 221 
AA2 1 LEU A 149 ? ALA A 151 ? LEU A 177 ALA A 179 
AA2 2 ARG A 119 ? ASN A 121 ? ARG A 147 ASN A 149 
AA2 3 ALA A 169 ? MET A 173 ? ALA A 197 MET A 201 
AA2 4 LEU A 88  ? ALA A 103 ? LEU A 116 ALA A 131 
AA2 5 VAL A 227 ? THR A 239 ? VAL A 255 THR A 267 
AA2 6 ALA A 211 ? VAL A 215 ? ALA A 239 VAL A 243 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O SER A 40  ? O SER A 68  N ILE A 8   ? N ILE A 36  
AA1 2 3 N GLY A 9   ? N GLY A 37  O PHE A 61  ? O PHE A 89  
AA1 3 4 N VAL A 64  ? N VAL A 92  O THR A 235 ? O THR A 263 
AA1 4 5 O VAL A 232 ? O VAL A 260 N GLU A 97  ? N GLU A 125 
AA1 5 6 N ILE A 101 ? N ILE A 129 O VAL A 193 ? O VAL A 221 
AA2 1 2 O LEU A 149 ? O LEU A 177 N VAL A 120 ? N VAL A 148 
AA2 2 3 N ASN A 121 ? N ASN A 149 O ALA A 169 ? O ALA A 197 
AA2 3 4 O PHE A 170 ? O PHE A 198 N ILE A 102 ? N ILE A 130 
AA2 4 5 N GLU A 97  ? N GLU A 125 O VAL A 232 ? O VAL A 260 
AA2 5 6 O GLY A 231 ? O GLY A 259 N ALA A 211 ? N ALA A 239 
# 
_pdbx_entry_details.entry_id                   8S4J 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 THR A 38  ? ? -128.10 -105.01 
2 1 SER A 105 ? ? 60.95   -122.94 
3 1 MET A 122 ? ? -140.63 -130.21 
4 1 ASP A 192 ? B -68.65  2.78    
5 1 CYS A 216 ? A -140.37 18.96   
6 1 SER A 257 ? ? -154.43 -150.90 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1  x,y,z                  
2  -y,x-y,z               
3  -x+y,-x,z              
4  x-y,-y,-z              
5  -x,-x+y,-z             
6  y,x,-z                 
7  x+1/3,y+2/3,z+2/3      
8  -y+1/3,x-y+2/3,z+2/3   
9  -x+y+1/3,-x+2/3,z+2/3  
10 x-y+1/3,-y+2/3,-z+2/3  
11 -x+1/3,-x+y+2/3,-z+2/3 
12 y+1/3,x+2/3,-z+2/3     
13 x+2/3,y+1/3,z+1/3      
14 -y+2/3,x-y+1/3,z+1/3   
15 -x+y+2/3,-x+1/3,z+1/3  
16 x-y+2/3,-y+1/3,-z+1/3  
17 -x+2/3,-x+y+1/3,-z+1/3 
18 y+2/3,x+1/3,-z+1/3     
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      A 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       758 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   5.92 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CYS N    N  N N 74  
CYS CA   C  N R 75  
CYS C    C  N N 76  
CYS O    O  N N 77  
CYS CB   C  N N 78  
CYS SG   S  N N 79  
CYS OXT  O  N N 80  
CYS H    H  N N 81  
CYS H2   H  N N 82  
CYS HA   H  N N 83  
CYS HB2  H  N N 84  
CYS HB3  H  N N 85  
CYS HG   H  N N 86  
CYS HXT  H  N N 87  
GLN N    N  N N 88  
GLN CA   C  N S 89  
GLN C    C  N N 90  
GLN O    O  N N 91  
GLN CB   C  N N 92  
GLN CG   C  N N 93  
GLN CD   C  N N 94  
GLN OE1  O  N N 95  
GLN NE2  N  N N 96  
GLN OXT  O  N N 97  
GLN H    H  N N 98  
GLN H2   H  N N 99  
GLN HA   H  N N 100 
GLN HB2  H  N N 101 
GLN HB3  H  N N 102 
GLN HG2  H  N N 103 
GLN HG3  H  N N 104 
GLN HE21 H  N N 105 
GLN HE22 H  N N 106 
GLN HXT  H  N N 107 
GLU N    N  N N 108 
GLU CA   C  N S 109 
GLU C    C  N N 110 
GLU O    O  N N 111 
GLU CB   C  N N 112 
GLU CG   C  N N 113 
GLU CD   C  N N 114 
GLU OE1  O  N N 115 
GLU OE2  O  N N 116 
GLU OXT  O  N N 117 
GLU H    H  N N 118 
GLU H2   H  N N 119 
GLU HA   H  N N 120 
GLU HB2  H  N N 121 
GLU HB3  H  N N 122 
GLU HG2  H  N N 123 
GLU HG3  H  N N 124 
GLU HE2  H  N N 125 
GLU HXT  H  N N 126 
GLY N    N  N N 127 
GLY CA   C  N N 128 
GLY C    C  N N 129 
GLY O    O  N N 130 
GLY OXT  O  N N 131 
GLY H    H  N N 132 
GLY H2   H  N N 133 
GLY HA2  H  N N 134 
GLY HA3  H  N N 135 
GLY HXT  H  N N 136 
HIS N    N  N N 137 
HIS CA   C  N S 138 
HIS C    C  N N 139 
HIS O    O  N N 140 
HIS CB   C  N N 141 
HIS CG   C  Y N 142 
HIS ND1  N  Y N 143 
HIS CD2  C  Y N 144 
HIS CE1  C  Y N 145 
HIS NE2  N  Y N 146 
HIS OXT  O  N N 147 
HIS H    H  N N 148 
HIS H2   H  N N 149 
HIS HA   H  N N 150 
HIS HB2  H  N N 151 
HIS HB3  H  N N 152 
HIS HD1  H  N N 153 
HIS HD2  H  N N 154 
HIS HE1  H  N N 155 
HIS HE2  H  N N 156 
HIS HXT  H  N N 157 
HOH O    O  N N 158 
HOH H1   H  N N 159 
HOH H2   H  N N 160 
ILE N    N  N N 161 
ILE CA   C  N S 162 
ILE C    C  N N 163 
ILE O    O  N N 164 
ILE CB   C  N S 165 
ILE CG1  C  N N 166 
ILE CG2  C  N N 167 
ILE CD1  C  N N 168 
ILE OXT  O  N N 169 
ILE H    H  N N 170 
ILE H2   H  N N 171 
ILE HA   H  N N 172 
ILE HB   H  N N 173 
ILE HG12 H  N N 174 
ILE HG13 H  N N 175 
ILE HG21 H  N N 176 
ILE HG22 H  N N 177 
ILE HG23 H  N N 178 
ILE HD11 H  N N 179 
ILE HD12 H  N N 180 
ILE HD13 H  N N 181 
ILE HXT  H  N N 182 
LEU N    N  N N 183 
LEU CA   C  N S 184 
LEU C    C  N N 185 
LEU O    O  N N 186 
LEU CB   C  N N 187 
LEU CG   C  N N 188 
LEU CD1  C  N N 189 
LEU CD2  C  N N 190 
LEU OXT  O  N N 191 
LEU H    H  N N 192 
LEU H2   H  N N 193 
LEU HA   H  N N 194 
LEU HB2  H  N N 195 
LEU HB3  H  N N 196 
LEU HG   H  N N 197 
LEU HD11 H  N N 198 
LEU HD12 H  N N 199 
LEU HD13 H  N N 200 
LEU HD21 H  N N 201 
LEU HD22 H  N N 202 
LEU HD23 H  N N 203 
LEU HXT  H  N N 204 
LYS N    N  N N 205 
LYS CA   C  N S 206 
LYS C    C  N N 207 
LYS O    O  N N 208 
LYS CB   C  N N 209 
LYS CG   C  N N 210 
LYS CD   C  N N 211 
LYS CE   C  N N 212 
LYS NZ   N  N N 213 
LYS OXT  O  N N 214 
LYS H    H  N N 215 
LYS H2   H  N N 216 
LYS HA   H  N N 217 
LYS HB2  H  N N 218 
LYS HB3  H  N N 219 
LYS HG2  H  N N 220 
LYS HG3  H  N N 221 
LYS HD2  H  N N 222 
LYS HD3  H  N N 223 
LYS HE2  H  N N 224 
LYS HE3  H  N N 225 
LYS HZ1  H  N N 226 
LYS HZ2  H  N N 227 
LYS HZ3  H  N N 228 
LYS HXT  H  N N 229 
MET N    N  N N 230 
MET CA   C  N S 231 
MET C    C  N N 232 
MET O    O  N N 233 
MET CB   C  N N 234 
MET CG   C  N N 235 
MET SD   S  N N 236 
MET CE   C  N N 237 
MET OXT  O  N N 238 
MET H    H  N N 239 
MET H2   H  N N 240 
MET HA   H  N N 241 
MET HB2  H  N N 242 
MET HB3  H  N N 243 
MET HG2  H  N N 244 
MET HG3  H  N N 245 
MET HE1  H  N N 246 
MET HE2  H  N N 247 
MET HE3  H  N N 248 
MET HXT  H  N N 249 
NA  NA   NA N N 250 
PHE N    N  N N 251 
PHE CA   C  N S 252 
PHE C    C  N N 253 
PHE O    O  N N 254 
PHE CB   C  N N 255 
PHE CG   C  Y N 256 
PHE CD1  C  Y N 257 
PHE CD2  C  Y N 258 
PHE CE1  C  Y N 259 
PHE CE2  C  Y N 260 
PHE CZ   C  Y N 261 
PHE OXT  O  N N 262 
PHE H    H  N N 263 
PHE H2   H  N N 264 
PHE HA   H  N N 265 
PHE HB2  H  N N 266 
PHE HB3  H  N N 267 
PHE HD1  H  N N 268 
PHE HD2  H  N N 269 
PHE HE1  H  N N 270 
PHE HE2  H  N N 271 
PHE HZ   H  N N 272 
PHE HXT  H  N N 273 
PRO N    N  N N 274 
PRO CA   C  N S 275 
PRO C    C  N N 276 
PRO O    O  N N 277 
PRO CB   C  N N 278 
PRO CG   C  N N 279 
PRO CD   C  N N 280 
PRO OXT  O  N N 281 
PRO H    H  N N 282 
PRO HA   H  N N 283 
PRO HB2  H  N N 284 
PRO HB3  H  N N 285 
PRO HG2  H  N N 286 
PRO HG3  H  N N 287 
PRO HD2  H  N N 288 
PRO HD3  H  N N 289 
PRO HXT  H  N N 290 
SER N    N  N N 291 
SER CA   C  N S 292 
SER C    C  N N 293 
SER O    O  N N 294 
SER CB   C  N N 295 
SER OG   O  N N 296 
SER OXT  O  N N 297 
SER H    H  N N 298 
SER H2   H  N N 299 
SER HA   H  N N 300 
SER HB2  H  N N 301 
SER HB3  H  N N 302 
SER HG   H  N N 303 
SER HXT  H  N N 304 
THR N    N  N N 305 
THR CA   C  N S 306 
THR C    C  N N 307 
THR O    O  N N 308 
THR CB   C  N R 309 
THR OG1  O  N N 310 
THR CG2  C  N N 311 
THR OXT  O  N N 312 
THR H    H  N N 313 
THR H2   H  N N 314 
THR HA   H  N N 315 
THR HB   H  N N 316 
THR HG1  H  N N 317 
THR HG21 H  N N 318 
THR HG22 H  N N 319 
THR HG23 H  N N 320 
THR HXT  H  N N 321 
TRP N    N  N N 322 
TRP CA   C  N S 323 
TRP C    C  N N 324 
TRP O    O  N N 325 
TRP CB   C  N N 326 
TRP CG   C  Y N 327 
TRP CD1  C  Y N 328 
TRP CD2  C  Y N 329 
TRP NE1  N  Y N 330 
TRP CE2  C  Y N 331 
TRP CE3  C  Y N 332 
TRP CZ2  C  Y N 333 
TRP CZ3  C  Y N 334 
TRP CH2  C  Y N 335 
TRP OXT  O  N N 336 
TRP H    H  N N 337 
TRP H2   H  N N 338 
TRP HA   H  N N 339 
TRP HB2  H  N N 340 
TRP HB3  H  N N 341 
TRP HD1  H  N N 342 
TRP HE1  H  N N 343 
TRP HE3  H  N N 344 
TRP HZ2  H  N N 345 
TRP HZ3  H  N N 346 
TRP HH2  H  N N 347 
TRP HXT  H  N N 348 
TYR N    N  N N 349 
TYR CA   C  N S 350 
TYR C    C  N N 351 
TYR O    O  N N 352 
TYR CB   C  N N 353 
TYR CG   C  Y N 354 
TYR CD1  C  Y N 355 
TYR CD2  C  Y N 356 
TYR CE1  C  Y N 357 
TYR CE2  C  Y N 358 
TYR CZ   C  Y N 359 
TYR OH   O  N N 360 
TYR OXT  O  N N 361 
TYR H    H  N N 362 
TYR H2   H  N N 363 
TYR HA   H  N N 364 
TYR HB2  H  N N 365 
TYR HB3  H  N N 366 
TYR HD1  H  N N 367 
TYR HD2  H  N N 368 
TYR HE1  H  N N 369 
TYR HE2  H  N N 370 
TYR HH   H  N N 371 
TYR HXT  H  N N 372 
VAL N    N  N N 373 
VAL CA   C  N S 374 
VAL C    C  N N 375 
VAL O    O  N N 376 
VAL CB   C  N N 377 
VAL CG1  C  N N 378 
VAL CG2  C  N N 379 
VAL OXT  O  N N 380 
VAL H    H  N N 381 
VAL H2   H  N N 382 
VAL HA   H  N N 383 
VAL HB   H  N N 384 
VAL HG11 H  N N 385 
VAL HG12 H  N N 386 
VAL HG13 H  N N 387 
VAL HG21 H  N N 388 
VAL HG22 H  N N 389 
VAL HG23 H  N N 390 
VAL HXT  H  N N 391 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
# 
_pdbx_audit_support.funding_organization   'Biotechnology and Biological Sciences Research Council (BBSRC)' 
_pdbx_audit_support.country                'United Kingdom' 
_pdbx_audit_support.grant_number           BB/V007424/1 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'in silico model' 
_pdbx_initial_refinement_model.source_name      AlphaFold 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'R 3 2 :H' 
_space_group.name_Hall        
;R 3 2"
;
_space_group.IT_number        155 
_space_group.crystal_system   trigonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    8S4J 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.007895 
_atom_sites.fract_transf_matrix[1][2]   0.004558 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.009117 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.005547 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C   ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N   ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
NA  ? ? 9.38062 1.54875 ? ? 3.38349  72.32734 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O   ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O1- ? ? 5.12366 3.84317 ? ? 3.49406  27.47979 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S   ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . ARG A 1 1   ? -41.24244 -19.88922 1.31521   1.000 50.27346 ?  29  ARG A N   1 
ATOM   2    C  CA  . ARG A 1 1   ? -40.16314 -19.89594 2.30368   1.000 42.74653 ?  29  ARG A CA  1 
ATOM   3    C  C   . ARG A 1 1   ? -39.98754 -18.52369 2.95889   1.000 54.41875 ?  29  ARG A C   1 
ATOM   4    O  O   . ARG A 1 1   ? -39.25482 -17.66917 2.44484   1.000 49.00812 ?  29  ARG A O   1 
ATOM   5    C  CB  . ARG A 1 1   ? -38.83355 -20.30500 1.66507   1.000 45.84395 ?  29  ARG A CB  1 
ATOM   6    C  CG  . ARG A 1 1   ? -38.86754 -21.58986 0.86398   1.000 46.26155 ?  29  ARG A CG  1 
ATOM   7    C  CD  . ARG A 1 1   ? -39.12670 -22.80736 1.71193   1.000 34.24958 ?  29  ARG A CD  1 
ATOM   8    N  NE  . ARG A 1 1   ? -39.20387 -24.00837 0.88268   1.000 32.05794 ?  29  ARG A NE  1 
ATOM   9    C  CZ  . ARG A 1 1   ? -39.74619 -25.15413 1.27336   1.000 36.43215 ?  29  ARG A CZ  1 
ATOM   10   N  NH1 . ARG A 1 1   ? -40.21213 -25.31189 2.50141   1.000 33.61849 ?  29  ARG A NH1 1 
ATOM   11   N  NH2 . ARG A 1 1   ? -39.79218 -26.17491 0.42157   1.000 34.15863 ?  29  ARG A NH2 1 
ATOM   12   N  N   . ALA A 1 2   ? -40.63315 -18.31827 4.10112   1.000 35.96044 ?  30  ALA A N   1 
ATOM   13   C  CA  . ALA A 1 2   ? -40.47474 -17.06982 4.82492   1.000 35.10316 ?  30  ALA A CA  1 
ATOM   14   C  C   . ALA A 1 2   ? -39.17198 -17.05964 5.61246   1.000 28.33177 ?  30  ALA A C   1 
ATOM   15   O  O   . ALA A 1 2   ? -38.68043 -18.09649 6.07404   1.000 36.34042 ?  30  ALA A O   1 
ATOM   16   C  CB  . ALA A 1 2   ? -41.65002 -16.83285 5.77406   1.000 33.91840 ?  30  ALA A CB  1 
ATOM   17   N  N   . GLN A 1 3   ? -38.63373 -15.85593 5.78096   1.000 26.65816 ?  31  GLN A N   1 
ATOM   18   C  CA  . GLN A 1 3   ? -37.40932 -15.60980 6.52039   1.000 28.78361 ?  31  GLN A CA  1 
ATOM   19   C  C   . GLN A 1 3   ? -37.66974 -15.53552 8.01651   1.000 31.69737 ?  31  GLN A C   1 
ATOM   20   O  O   . GLN A 1 3   ? -36.72722 -15.61578 8.81087   1.000 34.61681 ?  31  GLN A O   1 
ATOM   21   C  CB  . GLN A 1 3   ? -36.81483 -14.27404 6.05326   1.000 46.00022 ?  31  GLN A CB  1 
ATOM   22   C  CG  . GLN A 1 3   ? -35.83400 -14.34515 4.89655   1.000 51.51017 ?  31  GLN A CG  1 
ATOM   23   C  CD  . GLN A 1 3   ? -34.56051 -15.05045 5.25728   1.000 64.27775 ?  31  GLN A CD  1 
ATOM   24   O  OE1 . GLN A 1 3   ? -34.47468 -16.26071 5.11948   1.000 71.04205 ?  31  GLN A OE1 1 
ATOM   25   N  NE2 . GLN A 1 3   ? -33.55531 -14.30232 5.70882   1.000 59.43483 ?  31  GLN A NE2 1 
ATOM   26   N  N   . ASP A 1 4   ? -38.93357 -15.37211 8.40986   1.000 28.13653 ?  32  ASP A N   1 
ATOM   27   C  CA  . ASP A 1 4   ? -39.27057 -15.02396 9.78142   1.000 25.35459 ?  32  ASP A CA  1 
ATOM   28   C  C   . ASP A 1 4   ? -40.25388 -16.00319 10.41024  1.000 26.36101 ?  32  ASP A C   1 
ATOM   29   O  O   . ASP A 1 4   ? -40.72457 -15.75799 11.52609  1.000 26.91096 ?  32  ASP A O   1 
ATOM   30   C  CB  . ASP A 1 4   ? -39.83409 -13.59650 9.83229   1.000 29.10363 ?  32  ASP A CB  1 
ATOM   31   C  CG  . ASP A 1 4   ? -41.09618 -13.42825 8.99653   1.000 30.57683 ?  32  ASP A CG  1 
ATOM   32   O  OD1 . ASP A 1 4   ? -41.46563 -14.34852 8.25108   1.000 30.86522 ?  32  ASP A OD1 1 
ATOM   33   O  OD2 . ASP A 1 4   ? -41.72760 -12.35184 9.07855   1.000 40.63592 ?  32  ASP A OD2 1 
ATOM   34   N  N   . PHE A 1 5   ? -40.57640 -17.09741 9.73379   1.000 24.63958 ?  33  PHE A N   1 
ATOM   35   C  CA  . PHE A 1 5   ? -41.47919 -18.09696 10.28663  1.000 23.89040 ?  33  PHE A CA  1 
ATOM   36   C  C   . PHE A 1 5   ? -41.11885 -19.44121 9.68205   1.000 23.88379 ?  33  PHE A C   1 
ATOM   37   O  O   . PHE A 1 5   ? -41.02535 -19.55922 8.45455   1.000 26.50207 ?  33  PHE A O   1 
ATOM   38   C  CB  . PHE A 1 5   ? -42.93844 -17.74994 9.98409   1.000 27.36405 ?  33  PHE A CB  1 
ATOM   39   C  CG  . PHE A 1 5   ? -43.91782 -18.74990 10.52425  1.000 26.27796 ?  33  PHE A CG  1 
ATOM   40   C  CD1 . PHE A 1 5   ? -44.24936 -18.75394 11.87616  1.000 27.33480 ?  33  PHE A CD1 1 
ATOM   41   C  CD2 . PHE A 1 5   ? -44.49838 -19.69325 9.69580   1.000 27.32616 ?  33  PHE A CD2 1 
ATOM   42   C  CE1 . PHE A 1 5   ? -45.15940 -19.67283 12.37587  1.000 24.19700 ?  33  PHE A CE1 1 
ATOM   43   C  CE2 . PHE A 1 5   ? -45.39589 -20.62393 10.20182  1.000 25.49509 ?  33  PHE A CE2 1 
ATOM   44   C  CZ  . PHE A 1 5   ? -45.72096 -20.61516 11.54072  1.000 24.44432 ?  33  PHE A CZ  1 
ATOM   45   N  N   . ILE A 1 6   ? -40.90567 -20.44573 10.53023  1.000 23.52063 ?  34  ILE A N   1 
ATOM   46   C  CA  . ILE A 1 6   ? -40.55922 -21.78018 10.05707  1.000 21.44944 ?  34  ILE A CA  1 
ATOM   47   C  C   . ILE A 1 6   ? -41.42112 -22.80766 10.77376  1.000 25.91106 ?  34  ILE A C   1 
ATOM   48   O  O   . ILE A 1 6   ? -41.86545 -22.59941 11.90679  1.000 23.96318 ?  34  ILE A O   1 
ATOM   49   C  CB  . ILE A 1 6   ? -39.06111 -22.09725 10.25913  1.000 20.74973 ?  34  ILE A CB  1 
ATOM   50   C  CG1 . ILE A 1 6   ? -38.69632 -22.06748 11.74820  1.000 21.82738 ?  34  ILE A CG1 1 
ATOM   51   C  CG2 . ILE A 1 6   ? -38.19386 -21.12263 9.43436   1.000 21.25283 ?  34  ILE A CG2 1 
ATOM   52   C  CD1 . ILE A 1 6   ? -37.27433 -22.58858 12.05241  1.000 20.49302 ?  34  ILE A CD1 1 
ATOM   53   N  N   . THR A 1 7   ? -41.65122 -23.92962 10.10244  1.000 22.35319 ?  35  THR A N   1 
ATOM   54   C  CA  A THR A 1 7   ? -42.42590 -25.03447 10.64660  0.721 19.94463 ?  35  THR A CA  1 
ATOM   55   C  CA  B THR A 1 7   ? -42.42177 -25.03581 10.65486  0.279 20.07717 ?  35  THR A CA  1 
ATOM   56   C  C   . THR A 1 7   ? -41.58261 -26.30083 10.59334  1.000 23.43068 ?  35  THR A C   1 
ATOM   57   O  O   . THR A 1 7   ? -40.99059 -26.60016 9.55737   1.000 23.31039 ?  35  THR A O   1 
ATOM   58   C  CB  A THR A 1 7   ? -43.71505 -25.24184 9.85488   0.721 22.48737 ?  35  THR A CB  1 
ATOM   59   C  CB  B THR A 1 7   ? -43.72823 -25.25190 9.88949   0.279 22.51004 ?  35  THR A CB  1 
ATOM   60   O  OG1 A THR A 1 7   ? -44.42721 -24.00262 9.76009   0.721 23.68072 ?  35  THR A OG1 1 
ATOM   61   O  OG1 B THR A 1 7   ? -43.44291 -25.39306 8.49086   0.279 21.85827 ?  35  THR A OG1 1 
ATOM   62   C  CG2 A THR A 1 7   ? -44.57885 -26.25548 10.52679  0.721 24.49137 ?  35  THR A CG2 1 
ATOM   63   C  CG2 B THR A 1 7   ? -44.67065 -24.08528 10.10194  0.279 23.86080 ?  35  THR A CG2 1 
ATOM   64   N  N   . ILE A 1 8   ? -41.54051 -27.04238 11.69648  1.000 21.10685 ?  36  ILE A N   1 
ATOM   65   C  CA  . ILE A 1 8   ? -40.80886 -28.30607 11.77831  1.000 20.19278 ?  36  ILE A CA  1 
ATOM   66   C  C   . ILE A 1 8   ? -41.82371 -29.44515 11.82892  1.000 24.09565 ?  36  ILE A C   1 
ATOM   67   O  O   . ILE A 1 8   ? -42.61665 -29.53130 12.77258  1.000 21.03368 ?  36  ILE A O   1 
ATOM   68   C  CB  . ILE A 1 8   ? -39.89672 -28.35353 13.01435  1.000 19.42837 ?  36  ILE A CB  1 
ATOM   69   C  CG1 . ILE A 1 8   ? -38.99447 -27.11287 13.07850  1.000 19.41262 ?  36  ILE A CG1 1 
ATOM   70   C  CG2 . ILE A 1 8   ? -39.11014 -29.66592 13.02768  1.000 21.41286 ?  36  ILE A CG2 1 
ATOM   71   C  CD1 . ILE A 1 8   ? -37.91136 -27.20710 14.15631  1.000 22.16815 ?  36  ILE A CD1 1 
ATOM   72   N  N   . GLY A 1 9   ? -41.78741 -30.34289 10.84353  1.000 18.94106 ?  37  GLY A N   1 
ATOM   73   C  CA  . GLY A 1 9   ? -42.62702 -31.54789 10.91155  1.000 18.89547 ?  37  GLY A CA  1 
ATOM   74   C  C   . GLY A 1 9   ? -41.98431 -32.62460 11.78188  1.000 22.28199 ?  37  GLY A C   1 
ATOM   75   O  O   . GLY A 1 9   ? -40.77106 -32.81798 11.76527  1.000 22.13617 ?  37  GLY A O   1 
ATOM   76   N  N   . THR A 1 10  ? -42.81546 -33.32880 12.56932  1.000 17.69530 ?  38  THR A N   1 
ATOM   77   C  CA  . THR A 1 10  ? -42.26229 -34.27272 13.54377  1.000 18.63531 ?  38  THR A CA  1 
ATOM   78   C  C   . THR A 1 10  ? -42.87828 -35.66788 13.43752  1.000 20.56233 ?  38  THR A C   1 
ATOM   79   O  O   . THR A 1 10  ? -42.52698 -36.43407 12.53432  1.000 20.29563 ?  38  THR A O   1 
ATOM   80   C  CB  . THR A 1 10  ? -42.40795 -33.72252 14.97875  1.000 19.70941 ?  38  THR A CB  1 
ATOM   81   O  OG1 . THR A 1 10  ? -43.79506 -33.50867 15.28418  1.000 19.31779 ?  38  THR A OG1 1 
ATOM   82   C  CG2 . THR A 1 10  ? -41.68206 -32.38961 15.11899  1.000 22.14249 ?  38  THR A CG2 1 
ATOM   83   N  N   . GLY A 1 11  ? -43.75299 -36.03367 14.36369  1.000 18.90081 ?  39  GLY A N   1 
ATOM   84   C  CA  . GLY A 1 11  ? -44.36916 -37.34138 14.36782  1.000 18.48534 ?  39  GLY A CA  1 
ATOM   85   C  C   . GLY A 1 11  ? -45.59704 -37.31338 15.26066  1.000 21.80856 ?  39  GLY A C   1 
ATOM   86   O  O   . GLY A 1 11  ? -46.16508 -36.25277 15.51334  1.000 21.92469 ?  39  GLY A O   1 
ATOM   87   N  N   . SER A 1 12  ? -46.00270 -38.49407 15.72762  1.000 19.59606 ?  40  SER A N   1 
ATOM   88   C  CA  A SER A 1 12  ? -47.15004 -38.58387 16.62662  0.348 24.45201 ?  40  SER A CA  1 
ATOM   89   C  CA  B SER A 1 12  ? -47.15858 -38.57048 16.61502  0.652 24.47478 ?  40  SER A CA  1 
ATOM   90   C  C   . SER A 1 12  ? -46.83657 -37.92954 17.96437  1.000 25.79409 ?  40  SER A C   1 
ATOM   91   O  O   . SER A 1 12  ? -45.68466 -37.89552 18.41254  1.000 22.26623 ?  40  SER A O   1 
ATOM   92   C  CB  A SER A 1 12  ? -47.54937 -40.03339 16.86809  0.348 27.00834 ?  40  SER A CB  1 
ATOM   93   C  CB  B SER A 1 12  ? -47.60409 -40.02473 16.78486  0.652 27.08010 ?  40  SER A CB  1 
ATOM   94   O  OG  A SER A 1 12  ? -48.09482 -40.15753 18.17989  0.348 22.72027 ?  40  SER A OG  1 
ATOM   95   O  OG  B SER A 1 12  ? -49.01147 -40.17057 16.57502  0.652 27.52488 ?  40  SER A OG  1 
ATOM   96   N  N   . VAL A 1 13  ? -47.88103 -37.41658 18.62481  1.000 22.69419 ?  41  VAL A N   1 
ATOM   97   C  CA  . VAL A 1 13  ? -47.65001 -36.64301 19.83864  1.000 24.27635 ?  41  VAL A CA  1 
ATOM   98   C  C   . VAL A 1 13  ? -47.10852 -37.44627 21.01065  1.000 23.75568 ?  41  VAL A C   1 
ATOM   99   O  O   . VAL A 1 13  ? -46.64356 -36.83084 21.97777  1.000 27.34248 ?  41  VAL A O   1 
ATOM   100  C  CB  . VAL A 1 13  ? -48.92442 -35.89361 20.28580  1.000 23.81236 ?  41  VAL A CB  1 
ATOM   101  C  CG1 . VAL A 1 13  ? -49.30836 -34.84493 19.25688  1.000 30.33958 ?  41  VAL A CG1 1 
ATOM   102  C  CG2 . VAL A 1 13  ? -50.06949 -36.87070 20.55036  1.000 29.88206 ?  41  VAL A CG2 1 
ATOM   103  N  N   . THR A 1 14  ? -47.12124 -38.78348 20.98997  1.000 23.17155 ?  42  THR A N   1 
ATOM   104  C  CA  . THR A 1 14  ? -46.52279 -39.51235 22.10408  1.000 21.73276 ?  42  THR A CA  1 
ATOM   105  C  C   . THR A 1 14  ? -45.20238 -40.18961 21.72697  1.000 22.58340 ?  42  THR A C   1 
ATOM   106  O  O   . THR A 1 14  ? -44.71680 -41.05433 22.46668  1.000 24.62933 ?  42  THR A O   1 
ATOM   107  C  CB  . THR A 1 14  ? -47.50735 -40.52069 22.71280  1.000 30.48425 ?  42  THR A CB  1 
ATOM   108  O  OG1 . THR A 1 14  ? -47.87568 -41.50980 21.75182  1.000 29.43517 ?  42  THR A OG1 1 
ATOM   109  C  CG2 . THR A 1 14  ? -48.76302 -39.80219 23.21836  1.000 34.18293 ?  42  THR A CG2 1 
ATOM   110  N  N   . GLY A 1 15  ? -44.59288 -39.77642 20.61387  1.000 22.73774 ?  43  GLY A N   1 
ATOM   111  C  CA  . GLY A 1 15  ? -43.24679 -40.19150 20.26534  1.000 20.69102 ?  43  GLY A CA  1 
ATOM   112  C  C   . GLY A 1 15  ? -42.19141 -39.22715 20.77261  1.000 22.26876 ?  43  GLY A C   1 
ATOM   113  O  O   . GLY A 1 15  ? -42.41904 -38.43886 21.69847  1.000 21.04217 ?  43  GLY A O   1 
ATOM   114  N  N   . VAL A 1 16  ? -40.99261 -39.32307 20.17972  1.000 19.09237 ?  44  VAL A N   1 
ATOM   115  C  CA  . VAL A 1 16  ? -39.90441 -38.42829 20.58496  1.000 20.01739 ?  44  VAL A CA  1 
ATOM   116  C  C   . VAL A 1 16  ? -39.75928 -37.26568 19.60275  1.000 18.16741 ?  44  VAL A C   1 
ATOM   117  O  O   . VAL A 1 16  ? -39.36804 -36.16134 19.99129  1.000 18.66121 ?  44  VAL A O   1 
ATOM   118  C  CB  . VAL A 1 16  ? -38.57561 -39.20294 20.75030  1.000 17.89296 ?  44  VAL A CB  1 
ATOM   119  C  CG1 . VAL A 1 16  ? -37.43322 -38.26436 21.15375  1.000 20.21021 ?  44  VAL A CG1 1 
ATOM   120  C  CG2 . VAL A 1 16  ? -38.74309 -40.34501 21.74985  1.000 19.25433 ?  44  VAL A CG2 1 
ATOM   121  N  N   . TYR A 1 17  ? -40.06294 -37.48021 18.32196  1.000 19.11028 ?  45  TYR A N   1 
ATOM   122  C  CA  . TYR A 1 17  ? -39.90944 -36.38975 17.35621  1.000 19.28985 ?  45  TYR A CA  1 
ATOM   123  C  C   . TYR A 1 17  ? -40.70383 -35.14847 17.75998  1.000 19.63812 ?  45  TYR A C   1 
ATOM   124  O  O   . TYR A 1 17  ? -40.22318 -34.01831 17.63983  1.000 19.77984 ?  45  TYR A O   1 
ATOM   125  C  CB  . TYR A 1 17  ? -40.38834 -36.81987 15.98287  1.000 18.42013 ?  45  TYR A CB  1 
ATOM   126  C  CG  . TYR A 1 17  ? -39.49300 -37.72035 15.18909  1.000 18.22517 ?  45  TYR A CG  1 
ATOM   127  C  CD1 . TYR A 1 17  ? -38.39516 -38.37135 15.75193  1.000 18.24159 ?  45  TYR A CD1 1 
ATOM   128  C  CD2 . TYR A 1 17  ? -39.78011 -37.93256 13.84875  1.000 17.91827 ?  45  TYR A CD2 1 
ATOM   129  C  CE1 . TYR A 1 17  ? -37.59074 -39.20960 14.97778  1.000 18.11499 ?  45  TYR A CE1 1 
ATOM   130  C  CE2 . TYR A 1 17  ? -38.99664 -38.76773 13.06882  1.000 18.92172 ?  45  TYR A CE2 1 
ATOM   131  C  CZ  . TYR A 1 17  ? -37.90926 -39.39664 13.63055  1.000 18.59142 ?  45  TYR A CZ  1 
ATOM   132  O  OH  . TYR A 1 17  ? -37.18638 -40.24358 12.80918  1.000 19.70549 ?  45  TYR A OH  1 
ATOM   133  N  N   . TYR A 1 18  ? -41.95909 -35.34032 18.17183  1.000 18.76133 ?  46  TYR A N   1 
ATOM   134  C  CA  . TYR A 1 18  ? -42.79751 -34.19753 18.52420  1.000 19.77912 ?  46  TYR A CA  1 
ATOM   135  C  C   . TYR A 1 18  ? -42.18009 -33.34153 19.62961  1.000 19.75608 ?  46  TYR A C   1 
ATOM   136  O  O   . TYR A 1 18  ? -42.00671 -32.12889 19.41360  1.000 19.28128 ?  46  TYR A O   1 
ATOM   137  C  CB  . TYR A 1 18  ? -44.20841 -34.70360 18.87641  1.000 17.78370 ?  46  TYR A CB  1 
ATOM   138  C  CG  . TYR A 1 18  ? -45.17104 -33.58051 19.21940  1.000 19.90670 ?  46  TYR A CG  1 
ATOM   139  C  CD1 . TYR A 1 18  ? -45.58567 -32.67835 18.25396  1.000 23.06274 ?  46  TYR A CD1 1 
ATOM   140  C  CD2 . TYR A 1 18  ? -45.66188 -33.44004 20.52008  1.000 25.23732 ?  46  TYR A CD2 1 
ATOM   141  C  CE1 . TYR A 1 18  ? -46.47116 -31.64837 18.56221  1.000 26.92241 ?  46  TYR A CE1 1 
ATOM   142  C  CE2 . TYR A 1 18  ? -46.54972 -32.42018 20.83421  1.000 27.02711 ?  46  TYR A CE2 1 
ATOM   143  C  CZ  . TYR A 1 18  ? -46.94742 -31.53382 19.86002  1.000 31.89453 ?  46  TYR A CZ  1 
ATOM   144  O  OH  . TYR A 1 18  ? -47.82674 -30.52395 20.18754  1.000 33.84921 ?  46  TYR A OH  1 
ATOM   145  N  N   . PRO A 1 19  ? -41.80565 -33.87069 20.80105  1.000 19.45033 ?  47  PRO A N   1 
ATOM   146  C  CA  . PRO A 1 19  ? -41.14277 -32.99886 21.77943  1.000 21.64024 ?  47  PRO A CA  1 
ATOM   147  C  C   . PRO A 1 19  ? -39.77197 -32.52077 21.32314  1.000 22.69742 ?  47  PRO A C   1 
ATOM   148  O  O   . PRO A 1 19  ? -39.33350 -31.46026 21.77800  1.000 22.54099 ?  47  PRO A O   1 
ATOM   149  C  CB  . PRO A 1 19  ? -41.05393 -33.87303 23.04112  1.000 22.71549 ?  47  PRO A CB  1 
ATOM   150  C  CG  . PRO A 1 19  ? -41.21223 -35.27493 22.56856  1.000 19.71012 ?  47  PRO A CG  1 
ATOM   151  C  CD  . PRO A 1 19  ? -42.07365 -35.21114 21.35481  1.000 17.25407 ?  47  PRO A CD  1 
ATOM   152  N  N   . THR A 1 20  ? -39.09857 -33.25262 20.42554  1.000 19.43838 ?  48  THR A N   1 
ATOM   153  C  CA  . THR A 1 20  ? -37.83978 -32.76870 19.84694  1.000 22.25170 ?  48  THR A CA  1 
ATOM   154  C  C   . THR A 1 20  ? -38.06037 -31.48927 19.06197  1.000 18.80895 ?  48  THR A C   1 
ATOM   155  O  O   . THR A 1 20  ? -37.29690 -30.52122 19.19445  1.000 21.59111 ?  48  THR A O   1 
ATOM   156  C  CB  . THR A 1 20  ? -37.22038 -33.80727 18.90533  1.000 22.40108 ?  48  THR A CB  1 
ATOM   157  O  OG1 . THR A 1 20  ? -36.93411 -35.01236 19.60512  1.000 21.25678 ?  48  THR A OG1 1 
ATOM   158  C  CG2 . THR A 1 20  ? -35.92606 -33.24360 18.31610  1.000 24.03153 ?  48  THR A CG2 1 
ATOM   159  N  N   . GLY A 1 21  ? -39.08983 -31.47075 18.21780  1.000 19.16563 ?  49  GLY A N   1 
ATOM   160  C  CA  . GLY A 1 21  ? -39.42190 -30.25220 17.50562  1.000 21.92275 ?  49  GLY A CA  1 
ATOM   161  C  C   . GLY A 1 21  ? -39.71753 -29.11866 18.46491  1.000 22.07712 ?  49  GLY A C   1 
ATOM   162  O  O   . GLY A 1 21  ? -39.29873 -27.98173 18.24547  1.000 20.19783 ?  49  GLY A O   1 
ATOM   163  N  N   . GLY A 1 22  ? -40.43258 -29.42258 19.54762  1.000 21.08368 ?  50  GLY A N   1 
ATOM   164  C  CA  . GLY A 1 22  ? -40.72344 -28.39988 20.54259  1.000 21.46458 ?  50  GLY A CA  1 
ATOM   165  C  C   . GLY A 1 22  ? -39.47050 -27.82670 21.17832  1.000 21.01995 ?  50  GLY A C   1 
ATOM   166  O  O   . GLY A 1 22  ? -39.37409 -26.61905 21.39963  1.000 23.20609 ?  50  GLY A O   1 
ATOM   167  N  N   . ALA A 1 23  ? -38.49038 -28.68658 21.46374  1.000 19.72006 ?  51  ALA A N   1 
ATOM   168  C  CA  . ALA A 1 23  ? -37.24039 -28.25184 22.08224  1.000 22.98655 ?  51  ALA A CA  1 
ATOM   169  C  C   . ALA A 1 23  ? -36.45121 -27.35868 21.13668  1.000 22.93717 ?  51  ALA A C   1 
ATOM   170  O  O   . ALA A 1 23  ? -35.95703 -26.29413 21.53146  1.000 20.82063 ?  51  ALA A O   1 
ATOM   171  C  CB  . ALA A 1 23  ? -36.41182 -29.47787 22.47573  1.000 23.44194 ?  51  ALA A CB  1 
ATOM   172  N  N   . ILE A 1 24  ? -36.33119 -27.78118 19.87467  1.000 19.97833 ?  52  ILE A N   1 
ATOM   173  C  CA  . ILE A 1 24  ? -35.64978 -26.96687 18.87399  1.000 19.49496 ?  52  ILE A CA  1 
ATOM   174  C  C   . ILE A 1 24  ? -36.33195 -25.61596 18.72441  1.000 19.71416 ?  52  ILE A C   1 
ATOM   175  O  O   . ILE A 1 24  ? -35.67813 -24.56889 18.72530  1.000 21.95223 ?  52  ILE A O   1 
ATOM   176  C  CB  . ILE A 1 24  ? -35.59374 -27.70941 17.52837  1.000 19.21524 ?  52  ILE A CB  1 
ATOM   177  C  CG1 . ILE A 1 24  ? -34.76190 -28.98086 17.67529  1.000 21.71557 ?  52  ILE A CG1 1 
ATOM   178  C  CG2 . ILE A 1 24  ? -35.00752 -26.78204 16.45869  1.000 23.26641 ?  52  ILE A CG2 1 
ATOM   179  C  CD1 . ILE A 1 24  ? -34.79029 -29.90601 16.44178  1.000 22.59163 ?  52  ILE A CD1 1 
ATOM   180  N  N   . CYS A 1 25  ? -37.66015 -25.61781 18.58323  1.000 20.57250 ?  53  CYS A N   1 
ATOM   181  C  CA  . CYS A 1 25  ? -38.37057 -24.35514 18.42490  1.000 19.25430 ?  53  CYS A CA  1 
ATOM   182  C  C   . CYS A 1 25  ? -38.23058 -23.46670 19.65566  1.000 21.65580 ?  53  CYS A C   1 
ATOM   183  O  O   . CYS A 1 25  ? -38.15292 -22.24112 19.52487  1.000 22.13859 ?  53  CYS A O   1 
ATOM   184  C  CB  . CYS A 1 25  ? -39.84907 -24.60222 18.11800  1.000 20.63333 ?  53  CYS A CB  1 
ATOM   185  S  SG  . CYS A 1 25  ? -40.18837 -24.99740 16.36296  1.000 23.05629 ?  53  CYS A SG  1 
ATOM   186  N  N   . LYS A 1 26  ? -38.21865 -24.05137 20.86099  1.000 22.78947 ?  54  LYS A N   1 
ATOM   187  C  CA  . LYS A 1 26  ? -38.01439 -23.22075 22.04729  1.000 19.12021 ?  54  LYS A CA  1 
ATOM   188  C  C   . LYS A 1 26  ? -36.68419 -22.48837 21.97764  1.000 24.54441 ?  54  LYS A C   1 
ATOM   189  O  O   . LYS A 1 26  ? -36.60496 -21.29623 22.29321  1.000 23.49437 ?  54  LYS A O   1 
ATOM   190  C  CB  . LYS A 1 26  ? -38.05876 -24.06014 23.32777  1.000 25.20285 ?  54  LYS A CB  1 
ATOM   191  C  CG  . LYS A 1 26  ? -39.41125 -24.17660 23.96507  1.000 28.52103 ?  54  LYS A CG  1 
ATOM   192  C  CD  . LYS A 1 26  ? -39.25798 -24.64399 25.42356  1.000 26.91357 ?  54  LYS A CD  1 
ATOM   193  C  CE  . LYS A 1 26  ? -38.88898 -26.11856 25.47062  1.000 28.59961 ?  54  LYS A CE  1 
ATOM   194  N  NZ  . LYS A 1 26  ? -39.07870 -26.72857 26.83342  1.000 27.12934 ?  54  LYS A NZ  1 
ATOM   195  N  N   . LEU A 1 27  ? -35.62392 -23.18400 21.54871  1.000 20.93742 ?  55  LEU A N   1 
ATOM   196  C  CA  . LEU A 1 27  ? -34.31734 -22.53933 21.50023  1.000 19.95049 ?  55  LEU A CA  1 
ATOM   197  C  C   . LEU A 1 27  ? -34.22794 -21.51377 20.37343  1.000 25.25397 ?  55  LEU A C   1 
ATOM   198  O  O   . LEU A 1 27  ? -33.48239 -20.52827 20.49158  1.000 23.79809 ?  55  LEU A O   1 
ATOM   199  C  CB  . LEU A 1 27  ? -33.22001 -23.60327 21.37454  1.000 19.63295 ?  55  LEU A CB  1 
ATOM   200  C  CG  . LEU A 1 27  ? -33.13740 -24.51603 22.59291  1.000 18.78115 ?  55  LEU A CG  1 
ATOM   201  C  CD1 . LEU A 1 27  ? -32.10295 -25.60306 22.35554  1.000 21.70485 ?  55  LEU A CD1 1 
ATOM   202  C  CD2 . LEU A 1 27  ? -32.79190 -23.69273 23.87526  1.000 24.16925 ?  55  LEU A CD2 1 
ATOM   203  N  N   . VAL A 1 28  ? -34.96266 -21.71913 19.27774  1.000 21.19906 ?  56  VAL A N   1 
ATOM   204  C  CA  . VAL A 1 28  ? -35.04394 -20.68947 18.24998  1.000 19.80344 ?  56  VAL A CA  1 
ATOM   205  C  C   . VAL A 1 28  ? -35.84101 -19.49738 18.75820  1.000 25.27836 ?  56  VAL A C   1 
ATOM   206  O  O   . VAL A 1 28  ? -35.40930 -18.34456 18.64105  1.000 23.20513 ?  56  VAL A O   1 
ATOM   207  C  CB  . VAL A 1 28  ? -35.65880 -21.25230 16.95941  1.000 21.71526 ?  56  VAL A CB  1 
ATOM   208  C  CG1 . VAL A 1 28  ? -35.92930 -20.12532 15.95832  1.000 23.39597 ?  56  VAL A CG1 1 
ATOM   209  C  CG2 . VAL A 1 28  ? -34.75246 -22.32340 16.35493  1.000 23.16815 ?  56  VAL A CG2 1 
ATOM   210  N  N   . ASN A 1 29  ? -37.01834 -19.76206 19.33473  1.000 20.70589 ?  57  ASN A N   1 
ATOM   211  C  CA  . ASN A 1 29  ? -37.93123 -18.68030 19.68411  1.000 21.31439 ?  57  ASN A CA  1 
ATOM   212  C  C   . ASN A 1 29  ? -37.39486 -17.77115 20.77440  1.000 20.75059 ?  57  ASN A C   1 
ATOM   213  O  O   . ASN A 1 29  ? -37.83300 -16.61787 20.85338  1.000 23.41024 ?  57  ASN A O   1 
ATOM   214  C  CB  . ASN A 1 29  ? -39.27807 -19.25114 20.13167  1.000 20.48545 ?  57  ASN A CB  1 
ATOM   215  C  CG  . ASN A 1 29  ? -40.09654 -19.77316 18.98095  1.000 20.61288 ?  57  ASN A CG  1 
ATOM   216  O  OD1 . ASN A 1 29  ? -39.99374 -19.28089 17.86211  1.000 23.07001 ?  57  ASN A OD1 1 
ATOM   217  N  ND2 . ASN A 1 29  ? -40.91370 -20.77856 19.24868  1.000 22.37075 ?  57  ASN A ND2 1 
ATOM   218  N  N   . LYS A 1 30  ? -36.48616 -18.25241 21.62594  1.000 20.94135 ?  58  LYS A N   1 
ATOM   219  C  CA  . LYS A 1 30  ? -36.03628 -17.40452 22.72826  1.000 25.44207 ?  58  LYS A CA  1 
ATOM   220  C  C   . LYS A 1 30  ? -35.28381 -16.17554 22.23861  1.000 28.26389 ?  58  LYS A C   1 
ATOM   221  O  O   . LYS A 1 30  ? -35.18580 -15.19486 22.98052  1.000 27.13990 ?  58  LYS A O   1 
ATOM   222  C  CB  . LYS A 1 30  ? -35.16753 -18.19628 23.70718  1.000 28.10649 ?  58  LYS A CB  1 
ATOM   223  C  CG  . LYS A 1 30  ? -33.75144 -18.46128 23.22308  1.000 26.09538 ?  58  LYS A CG  1 
ATOM   224  C  CD  . LYS A 1 30  ? -32.95467 -19.31262 24.22561  1.000 25.20805 ?  58  LYS A CD  1 
ATOM   225  C  CE  . LYS A 1 30  ? -31.46600 -19.38957 23.86995  1.000 29.58185 ?  58  LYS A CE  1 
ATOM   226  N  NZ  . LYS A 1 30  ? -30.86614 -18.03633 23.58941  1.000 29.18521 ?  58  LYS A NZ  1 
ATOM   227  N  N   . ASP A 1 31  ? -34.77026 -16.18843 21.00603  1.000 24.79884 ?  59  ASP A N   1 
ATOM   228  C  CA  . ASP A 1 31  ? -34.08951 -15.02249 20.45138  1.000 27.23424 ?  59  ASP A CA  1 
ATOM   229  C  C   . ASP A 1 31  ? -34.83338 -14.41152 19.27273  1.000 27.53841 ?  59  ASP A C   1 
ATOM   230  O  O   . ASP A 1 31  ? -34.22484 -13.70274 18.45981  1.000 27.48481 ?  59  ASP A O   1 
ATOM   231  C  CB  . ASP A 1 31  ? -32.66184 -15.39228 20.05167  1.000 28.57423 ?  59  ASP A CB  1 
ATOM   232  C  CG  . ASP A 1 31  ? -31.86099 -15.90881 21.22308  1.000 28.13486 ?  59  ASP A CG  1 
ATOM   233  O  OD1 . ASP A 1 31  ? -31.81710 -15.20741 22.25572  1.000 29.76627 ?  59  ASP A OD1 1 
ATOM   234  O  OD2 . ASP A 1 31  ? -31.28191 -17.00724 21.12659  1.000 31.88230 ?  59  ASP A OD2 1 
ATOM   235  N  N   . ARG A 1 32  ? -36.14561 -14.64635 19.17759  1.000 23.81603 ?  60  ARG A N   1 
ATOM   236  C  CA  . ARG A 1 32  ? -36.91096 -14.14257 18.04914  1.000 22.63449 ?  60  ARG A CA  1 
ATOM   237  C  C   . ARG A 1 32  ? -36.88816 -12.62082 17.96092  1.000 27.58169 ?  60  ARG A C   1 
ATOM   238  O  O   . ARG A 1 32  ? -37.06577 -12.07427 16.86680  1.000 27.57764 ?  60  ARG A O   1 
ATOM   239  C  CB  . ARG A 1 32  ? -38.35276 -14.64337 18.12171  1.000 26.60191 ?  60  ARG A CB  1 
ATOM   240  C  CG  . ARG A 1 32  ? -39.19704 -14.01992 19.22654  1.000 27.16255 ?  60  ARG A CG  1 
ATOM   241  C  CD  . ARG A 1 32  ? -40.56935 -14.68751 19.27463  1.000 27.32778 ?  60  ARG A CD  1 
ATOM   242  N  NE  . ARG A 1 32  ? -41.35865 -14.24703 20.42071  1.000 30.56719 ?  60  ARG A NE  1 
ATOM   243  C  CZ  . ARG A 1 32  ? -41.21673 -14.68893 21.66139  1.000 40.87846 ?  60  ARG A CZ  1 
ATOM   244  N  NH1 . ARG A 1 32  ? -40.27107 -15.55807 21.98673  1.000 36.24395 ?  60  ARG A NH1 1 
ATOM   245  N  NH2 . ARG A 1 32  ? -42.03891 -14.23781 22.60466  1.000 47.11360 ?  60  ARG A NH2 1 
ATOM   246  N  N   . LYS A 1 33  ? -36.66532 -11.91934 19.07287  1.000 29.55398 ?  61  LYS A N   1 
ATOM   247  C  CA  . LYS A 1 33  ? -36.58878 -10.46538 18.98364  1.000 34.56316 ?  61  LYS A CA  1 
ATOM   248  C  C   . LYS A 1 33  ? -35.31110 -10.00082 18.29888  1.000 35.41435 ?  61  LYS A C   1 
ATOM   249  O  O   . LYS A 1 33  ? -35.24807 -8.84795  17.85468  1.000 39.93378 ?  61  LYS A O   1 
ATOM   250  C  CB  . LYS A 1 33  ? -36.71498 -9.84052  20.37400  1.000 31.57981 ?  61  LYS A CB  1 
ATOM   251  C  CG  . LYS A 1 33  ? -38.15527 -9.87493  20.88809  1.000 36.36081 ?  61  LYS A CG  1 
ATOM   252  C  CD  . LYS A 1 33  ? -38.23529 -9.85506  22.41187  1.000 45.63411 ?  61  LYS A CD  1 
ATOM   253  C  CE  . LYS A 1 33  ? -39.66044 -9.57132  22.87993  1.000 39.85364 ?  61  LYS A CE  1 
ATOM   254  N  NZ  . LYS A 1 33  ? -40.53293 -10.78760 22.79781  1.000 45.80071 ?  61  LYS A NZ  1 
ATOM   255  N  N   . ASP A 1 34  ? -34.31137 -10.87883 18.18261  1.000 30.46640 ?  62  ASP A N   1 
ATOM   256  C  CA  . ASP A 1 34  ? -33.05168 -10.58499 17.50394  1.000 34.30615 ?  62  ASP A CA  1 
ATOM   257  C  C   . ASP A 1 34  ? -33.05281 -11.09054 16.06512  1.000 36.43108 ?  62  ASP A C   1 
ATOM   258  O  O   . ASP A 1 34  ? -32.88344 -10.29859 15.13402  1.000 36.50626 ?  62  ASP A O   1 
ATOM   259  C  CB  . ASP A 1 34  ? -31.87545 -11.20518 18.26551  1.000 33.00673 ?  62  ASP A CB  1 
ATOM   260  C  CG  . ASP A 1 34  ? -31.66462 -10.57994 19.62897  1.000 51.36660 ?  62  ASP A CG  1 
ATOM   261  O  OD1 . ASP A 1 34  ? -32.11216 -9.43193  19.84053  1.000 52.87078 ?  62  ASP A OD1 1 
ATOM   262  O  OD2 . ASP A 1 34  ? -31.07112 -11.25551 20.49703  1.000 56.10522 ?  62  ASP A OD2 1 
ATOM   263  N  N   . HIS A 1 35  ? -33.23738 -12.40120 15.86036  1.000 27.98549 ?  63  HIS A N   1 
ATOM   264  C  CA  . HIS A 1 35  ? -33.14356 -12.95424 14.51266  1.000 25.30790 ?  63  HIS A CA  1 
ATOM   265  C  C   . HIS A 1 35  ? -34.47988 -12.99811 13.78452  1.000 28.79085 ?  63  HIS A C   1 
ATOM   266  O  O   . HIS A 1 35  ? -34.50605 -13.34371 12.59859  1.000 27.88192 ?  63  HIS A O   1 
ATOM   267  C  CB  . HIS A 1 35  ? -32.51133 -14.36141 14.53188  1.000 27.49456 ?  63  HIS A CB  1 
ATOM   268  C  CG  . HIS A 1 35  ? -33.18949 -15.33695 15.44915  1.000 25.03760 ?  63  HIS A CG  1 
ATOM   269  N  ND1 . HIS A 1 35  ? -34.54707 -15.57557 15.41887  1.000 24.84407 ?  63  HIS A ND1 1 
ATOM   270  C  CD2 . HIS A 1 35  ? -32.68186 -16.16873 16.39022  1.000 24.51919 ?  63  HIS A CD2 1 
ATOM   271  C  CE1 . HIS A 1 35  ? -34.85257 -16.48420 16.32989  1.000 23.11681 ?  63  HIS A CE1 1 
ATOM   272  N  NE2 . HIS A 1 35  ? -33.73772 -16.86470 16.93115  1.000 23.06483 ?  63  HIS A NE2 1 
ATOM   273  N  N   . ASN A 1 36  ? -35.57491 -12.63190 14.45066  1.000 25.66158 ?  64  ASN A N   1 
ATOM   274  C  CA  . ASN A 1 36  ? -36.91075 -12.47591 13.87561  1.000 25.13310 ?  64  ASN A CA  1 
ATOM   275  C  C   . ASN A 1 36  ? -37.55188 -13.79081 13.45384  1.000 25.49553 ?  64  ASN A C   1 
ATOM   276  O  O   . ASN A 1 36  ? -38.55100 -13.76085 12.74301  1.000 28.23623 ?  64  ASN A O   1 
ATOM   277  C  CB  . ASN A 1 36  ? -36.90358 -11.52964 12.66552  1.000 30.05272 ?  64  ASN A CB  1 
ATOM   278  C  CG  . ASN A 1 36  ? -36.21641 -10.20451 12.97012  1.000 41.33087 ?  64  ASN A CG  1 
ATOM   279  O  OD1 . ASN A 1 36  ? -36.57750 -9.50189  13.91545  1.000 50.87600 ?  64  ASN A OD1 1 
ATOM   280  N  ND2 . ASN A 1 36  ? -35.19716 -9.87330  12.17886  1.000 52.31358 ?  64  ASN A ND2 1 
ATOM   281  N  N   . ILE A 1 37  ? -37.01903 -14.94442 13.85642  1.000 22.48885 ?  65  ILE A N   1 
ATOM   282  C  CA  . ILE A 1 37  ? -37.58392 -16.23252 13.44472  1.000 22.60765 ?  65  ILE A CA  1 
ATOM   283  C  C   . ILE A 1 37  ? -38.50938 -16.76280 14.53228  1.000 23.22301 ?  65  ILE A C   1 
ATOM   284  O  O   . ILE A 1 37  ? -38.06321 -17.04390 15.65190  1.000 23.55891 ?  65  ILE A O   1 
ATOM   285  C  CB  . ILE A 1 37  ? -36.49676 -17.27310 13.14911  1.000 22.79798 ?  65  ILE A CB  1 
ATOM   286  C  CG1 . ILE A 1 37  ? -35.52335 -16.76365 12.08912  1.000 24.26815 ?  65  ILE A CG1 1 
ATOM   287  C  CG2 . ILE A 1 37  ? -37.14481 -18.56891 12.67390  1.000 23.18775 ?  65  ILE A CG2 1 
ATOM   288  C  CD1 . ILE A 1 37  ? -34.20373 -17.51451 12.11981  1.000 27.93863 ?  65  ILE A CD1 1 
ATOM   289  N  N   . ARG A 1 38  ? -39.77647 -16.95805 14.17480  1.000 22.51389 ?  66  ARG A N   1 
ATOM   290  C  CA  . ARG A 1 38  ? -40.73506 -17.70996 14.97750  1.000 23.61787 ?  66  ARG A CA  1 
ATOM   291  C  C   . ARG A 1 38  ? -40.78231 -19.14269 14.46377  1.000 23.08950 ?  66  ARG A C   1 
ATOM   292  O  O   . ARG A 1 38  ? -40.91779 -19.37377 13.25422  1.000 23.53862 ?  66  ARG A O   1 
ATOM   293  C  CB  . ARG A 1 38  ? -42.12664 -17.06039 14.91892  1.000 25.09759 ?  66  ARG A CB  1 
ATOM   294  C  CG  . ARG A 1 38  ? -43.30620 -17.97499 15.27413  1.000 24.83438 ?  66  ARG A CG  1 
ATOM   295  C  CD  . ARG A 1 38  ? -43.32435 -18.37185 16.73411  1.000 29.03554 ?  66  ARG A CD  1 
ATOM   296  N  NE  . ARG A 1 38  ? -43.55584 -17.22922 17.60601  1.000 30.80617 ?  66  ARG A NE  1 
ATOM   297  C  CZ  . ARG A 1 38  ? -43.66396 -17.31290 18.92763  1.000 36.65429 ?  66  ARG A CZ  1 
ATOM   298  N  NH1 . ARG A 1 38  ? -43.60861 -18.48018 19.55769  1.000 31.59454 ?  66  ARG A NH1 1 
ATOM   299  N  NH2 . ARG A 1 38  ? -43.81379 -16.20061 19.63403  1.000 32.02049 ?  66  ARG A NH2 1 
ATOM   300  N  N   . CYS A 1 39  ? -40.64584 -20.09502 15.37955  1.000 20.89497 ?  67  CYS A N   1 
ATOM   301  C  CA  . CYS A 1 39  ? -40.56760 -21.51359 15.06021  1.000 21.21464 ?  67  CYS A CA  1 
ATOM   302  C  C   . CYS A 1 39  ? -41.82130 -22.21522 15.56998  1.000 23.67253 ?  67  CYS A C   1 
ATOM   303  O  O   . CYS A 1 39  ? -42.18479 -22.07725 16.75205  1.000 22.62785 ?  67  CYS A O   1 
ATOM   304  C  CB  . CYS A 1 39  ? -39.30173 -22.11869 15.68933  1.000 20.18913 ?  67  CYS A CB  1 
ATOM   305  S  SG  . CYS A 1 39  ? -38.92044 -23.83706 15.24229  1.000 24.02611 ?  67  CYS A SG  1 
ATOM   306  N  N   . SER A 1 40  ? -42.46226 -22.98382 14.69206  1.000 21.16011 ?  68  SER A N   1 
ATOM   307  C  CA  A SER A 1 40  ? -43.66804 -23.72410 15.02945  0.571 21.88572 ?  68  SER A CA  1 
ATOM   308  C  CA  B SER A 1 40  ? -43.67808 -23.71944 15.00571  0.429 21.90790 ?  68  SER A CA  1 
ATOM   309  C  C   . SER A 1 40  ? -43.48088 -25.20209 14.71498  1.000 27.89305 ?  68  SER A C   1 
ATOM   310  O  O   . SER A 1 40  ? -42.75377 -25.57418 13.78926  1.000 24.08502 ?  68  SER A O   1 
ATOM   311  C  CB  A SER A 1 40  ? -44.88217 -23.18117 14.27648  0.571 26.49311 ?  68  SER A CB  1 
ATOM   312  C  CB  B SER A 1 40  ? -44.85856 -23.17758 14.19634  0.429 26.42497 ?  68  SER A CB  1 
ATOM   313  O  OG  A SER A 1 40  ? -44.84692 -23.55675 12.91467  0.571 24.47736 ?  68  SER A OG  1 
ATOM   314  O  OG  B SER A 1 40  ? -46.01598 -23.97430 14.36811  0.429 25.41830 ?  68  SER A OG  1 
ATOM   315  N  N   . VAL A 1 41  ? -44.14341 -26.04695 15.50633  1.000 23.28192 ?  69  VAL A N   1 
ATOM   316  C  CA  . VAL A 1 41  ? -44.05607 -27.50143 15.38370  1.000 21.93439 ?  69  VAL A CA  1 
ATOM   317  C  C   . VAL A 1 41  ? -45.37879 -28.04272 14.86524  1.000 27.28502 ?  69  VAL A C   1 
ATOM   318  O  O   . VAL A 1 41  ? -46.45091 -27.61851 15.31166  1.000 27.40356 ?  69  VAL A O   1 
ATOM   319  C  CB  . VAL A 1 41  ? -43.71819 -28.15967 16.73413  1.000 28.48624 ?  69  VAL A CB  1 
ATOM   320  C  CG1 . VAL A 1 41  ? -43.73321 -29.67844 16.61241  1.000 28.01258 ?  69  VAL A CG1 1 
ATOM   321  C  CG2 . VAL A 1 41  ? -42.40525 -27.66904 17.24755  1.000 29.73994 ?  69  VAL A CG2 1 
ATOM   322  N  N   . GLU A 1 42  ? -45.30614 -29.00061 13.94326  1.000 24.94817 ?  70  GLU A N   1 
ATOM   323  C  CA  . GLU A 1 42  ? -46.46902 -29.77551 13.52334  1.000 24.94880 ?  70  GLU A CA  1 
ATOM   324  C  C   . GLU A 1 42  ? -46.27907 -31.24248 13.86958  1.000 24.76797 ?  70  GLU A C   1 
ATOM   325  O  O   . GLU A 1 42  ? -45.23136 -31.82518 13.56484  1.000 22.96244 ?  70  GLU A O   1 
ATOM   326  C  CB  . GLU A 1 42  ? -46.71041 -29.66700 12.01797  1.000 30.75075 ?  70  GLU A CB  1 
ATOM   327  C  CG  . GLU A 1 42  ? -47.07613 -28.29381 11.54996  1.000 39.38323 ?  70  GLU A CG  1 
ATOM   328  C  CD  . GLU A 1 42  ? -48.55713 -28.02412 11.68361  1.000 46.92350 ?  70  GLU A CD  1 
ATOM   329  O  OE1 . GLU A 1 42  ? -49.30306 -28.95711 12.05507  1.000 50.95193 ?  70  GLU A OE1 1 
ATOM   330  O  OE2 . GLU A 1 42  ? -48.97521 -26.88599 11.38964  1.000 46.74675 ?  70  GLU A OE2 1 
ATOM   331  N  N   . SER A 1 43  ? -47.28617 -31.84376 14.49600  1.000 22.81365 ?  71  SER A N   1 
ATOM   332  C  CA  A SER A 1 43  ? -47.32980 -33.29724 14.55777  0.825 20.26248 ?  71  SER A CA  1 
ATOM   333  C  CA  B SER A 1 43  ? -47.34208 -33.29658 14.55816  0.175 20.39389 ?  71  SER A CA  1 
ATOM   334  C  C   . SER A 1 43  ? -47.71709 -33.83720 13.18269  1.000 22.01745 ?  71  SER A C   1 
ATOM   335  O  O   . SER A 1 43  ? -48.52897 -33.24162 12.46475  1.000 22.43204 ?  71  SER A O   1 
ATOM   336  C  CB  A SER A 1 43  ? -48.31619 -33.75857 15.62624  0.825 24.69815 ?  71  SER A CB  1 
ATOM   337  C  CB  B SER A 1 43  ? -48.35183 -33.74912 15.61030  0.175 24.56990 ?  71  SER A CB  1 
ATOM   338  O  OG  A SER A 1 43  ? -49.62747 -33.34692 15.28580  0.825 22.75827 ?  71  SER A OG  1 
ATOM   339  O  OG  B SER A 1 43  ? -48.43558 -35.15951 15.65834  0.175 21.33442 ?  71  SER A OG  1 
ATOM   340  N  N   . THR A 1 44  ? -47.09659 -34.94629 12.78539  1.000 20.40169 ?  72  THR A N   1 
ATOM   341  C  CA  . THR A 1 44  ? -47.27989 -35.46212 11.43125  1.000 21.65863 ?  72  THR A CA  1 
ATOM   342  C  C   . THR A 1 44  ? -47.23648 -36.98246 11.44920  1.000 21.20149 ?  72  THR A C   1 
ATOM   343  O  O   . THR A 1 44  ? -46.98980 -37.61068 12.48097  1.000 20.00208 ?  72  THR A O   1 
ATOM   344  C  CB  . THR A 1 44  ? -46.18347 -35.00496 10.45476  1.000 22.14387 ?  72  THR A CB  1 
ATOM   345  O  OG1 . THR A 1 44  ? -44.95886 -35.64530 10.84021  1.000 21.17990 ?  72  THR A OG1 1 
ATOM   346  C  CG2 . THR A 1 44  ? -46.00673 -33.49853 10.43212  1.000 21.93552 ?  72  THR A CG2 1 
ATOM   347  N  N   . GLY A 1 45  ? -47.40751 -37.57177 10.26462  1.000 20.49852 ?  73  GLY A N   1 
ATOM   348  C  CA  . GLY A 1 45  ? -47.30982 -39.01724 10.12724  1.000 20.43301 ?  73  GLY A CA  1 
ATOM   349  C  C   . GLY A 1 45  ? -45.90870 -39.58909 10.26995  1.000 19.98498 ?  73  GLY A C   1 
ATOM   350  O  O   . GLY A 1 45  ? -45.77673 -40.81048 10.38699  1.000 21.48455 ?  73  GLY A O   1 
ATOM   351  N  N   . GLY A 1 46  ? -44.86970 -38.75198 10.25945  1.000 19.29558 ?  74  GLY A N   1 
ATOM   352  C  CA  . GLY A 1 46  ? -43.50992 -39.26167 10.42410  1.000 20.05785 ?  74  GLY A CA  1 
ATOM   353  C  C   . GLY A 1 46  ? -42.58757 -38.96931 9.24250   1.000 18.66046 ?  74  GLY A C   1 
ATOM   354  O  O   . GLY A 1 46  ? -42.86967 -38.07567 8.44415   1.000 19.62743 ?  74  GLY A O   1 
ATOM   355  N  N   . SER A 1 47  ? -41.50461 -39.74924 9.13156   1.000 19.87821 ?  75  SER A N   1 
ATOM   356  C  CA  . SER A 1 47  ? -40.37806 -39.41318 8.25490   1.000 18.49266 ?  75  SER A CA  1 
ATOM   357  C  C   . SER A 1 47  ? -40.80121 -39.21359 6.81604   1.000 20.96846 ?  75  SER A C   1 
ATOM   358  O  O   . SER A 1 47  ? -40.30840 -38.29768 6.14835   1.000 19.21585 ?  75  SER A O   1 
ATOM   359  C  CB  . SER A 1 47  ? -39.31307 -40.51614 8.29449   1.000 17.23085 ?  75  SER A CB  1 
ATOM   360  O  OG  . SER A 1 47  ? -38.60468 -40.54907 9.51559   1.000 20.68168 ?  75  SER A OG  1 
ATOM   361  N  N   . ILE A 1 48  ? -41.63329 -40.11936 6.28588   1.000 19.22459 ?  76  ILE A N   1 
ATOM   362  C  CA  . ILE A 1 48  ? -41.92358 -40.08940 4.85086   1.000 20.08320 ?  76  ILE A CA  1 
ATOM   363  C  C   . ILE A 1 48  ? -42.76471 -38.86586 4.51012   1.000 23.18617 ?  76  ILE A C   1 
ATOM   364  O  O   . ILE A 1 48  ? -42.45410 -38.10421 3.58359   1.000 21.16508 ?  76  ILE A O   1 
ATOM   365  C  CB  . ILE A 1 48  ? -42.60277 -41.39898 4.41587   1.000 20.72554 ?  76  ILE A CB  1 
ATOM   366  C  CG1 . ILE A 1 48  ? -41.77136 -42.62406 4.83671   1.000 21.60010 ?  76  ILE A CG1 1 
ATOM   367  C  CG2 . ILE A 1 48  ? -42.86123 -41.39157 2.90693   1.000 22.56782 ?  76  ILE A CG2 1 
ATOM   368  C  CD1 . ILE A 1 48  ? -40.32268 -42.57927 4.36273   1.000 21.09912 ?  76  ILE A CD1 1 
ATOM   369  N  N   . TYR A 1 49  ? -43.83733 -38.64738 5.27050   1.000 21.97837 ?  77  TYR A N   1 
ATOM   370  C  CA  . TYR A 1 49  ? -44.59983 -37.41346 5.14568   1.000 21.35162 ?  77  TYR A CA  1 
ATOM   371  C  C   . TYR A 1 49  ? -43.69979 -36.19343 5.26105   1.000 19.58079 ?  77  TYR A C   1 
ATOM   372  O  O   . TYR A 1 49  ? -43.87169 -35.21193 4.53151   1.000 20.05346 ?  77  TYR A O   1 
ATOM   373  C  CB  . TYR A 1 49  ? -45.68519 -37.35763 6.22877   1.000 20.58296 ?  77  TYR A CB  1 
ATOM   374  C  CG  . TYR A 1 49  ? -46.46542 -36.05918 6.21218   1.000 21.99425 ?  77  TYR A CG  1 
ATOM   375  C  CD1 . TYR A 1 49  ? -46.03903 -34.93982 6.93487   1.000 20.02292 ?  77  TYR A CD1 1 
ATOM   376  C  CD2 . TYR A 1 49  ? -47.64102 -35.96096 5.47746   1.000 25.02450 ?  77  TYR A CD2 1 
ATOM   377  C  CE1 . TYR A 1 49  ? -46.76481 -33.76170 6.90948   1.000 22.72143 ?  77  TYR A CE1 1 
ATOM   378  C  CE2 . TYR A 1 49  ? -48.36247 -34.80374 5.44733   1.000 25.57807 ?  77  TYR A CE2 1 
ATOM   379  C  CZ  . TYR A 1 49  ? -47.92653 -33.70743 6.15883   1.000 26.79811 ?  77  TYR A CZ  1 
ATOM   380  O  OH  . TYR A 1 49  ? -48.67531 -32.55917 6.09780   1.000 26.32872 ?  77  TYR A OH  1 
ATOM   381  N  N   . ASN A 1 50  ? -42.75255 -36.21467 6.20482   1.000 19.60850 ?  78  ASN A N   1 
ATOM   382  C  CA  . ASN A 1 50  ? -41.95324 -35.01569 6.45050   1.000 20.09793 ?  78  ASN A CA  1 
ATOM   383  C  C   . ASN A 1 50  ? -41.09528 -34.67546 5.24207   1.000 21.17459 ?  78  ASN A C   1 
ATOM   384  O  O   . ASN A 1 50  ? -41.02701 -33.50920 4.83810   1.000 20.04946 ?  78  ASN A O   1 
ATOM   385  C  CB  . ASN A 1 50  ? -41.08015 -35.18485 7.68919   1.000 18.24945 ?  78  ASN A CB  1 
ATOM   386  C  CG  . ASN A 1 50  ? -41.89422 -35.19977 8.97508   1.000 19.83688 ?  78  ASN A CG  1 
ATOM   387  O  OD1 . ASN A 1 50  ? -43.04184 -34.74816 9.00164   1.000 20.48271 ?  78  ASN A OD1 1 
ATOM   388  N  ND2 . ASN A 1 50  ? -41.30799 -35.73558 10.03638  1.000 18.56210 ?  78  ASN A ND2 1 
ATOM   389  N  N   . VAL A 1 51  ? -40.43877 -35.67837 4.64145   1.000 20.90236 ?  79  VAL A N   1 
ATOM   390  C  CA  . VAL A 1 51  ? -39.65295 -35.40552 3.43447   1.000 20.45192 ?  79  VAL A CA  1 
ATOM   391  C  C   . VAL A 1 51  ? -40.55383 -34.86282 2.33223   1.000 20.06727 ?  79  VAL A C   1 
ATOM   392  O  O   . VAL A 1 51  ? -40.23305 -33.86147 1.67440   1.000 22.73978 ?  79  VAL A O   1 
ATOM   393  C  CB  . VAL A 1 51  ? -38.91040 -36.67334 2.96466   1.000 17.75149 ?  79  VAL A CB  1 
ATOM   394  C  CG1 . VAL A 1 51  ? -38.30964 -36.43817 1.55785   1.000 21.90622 ?  79  VAL A CG1 1 
ATOM   395  C  CG2 . VAL A 1 51  ? -37.81408 -37.05608 3.94211   1.000 18.12324 ?  79  VAL A CG2 1 
ATOM   396  N  N   . ASN A 1 52  ? -41.69010 -35.53118 2.10134   1.000 19.45395 ?  80  ASN A N   1 
ATOM   397  C  CA  . ASN A 1 52  ? -42.55003 -35.16966 0.98011   1.000 20.76081 ?  80  ASN A CA  1 
ATOM   398  C  C   . ASN A 1 52  ? -43.15200 -33.79040 1.16839   1.000 23.43671 ?  80  ASN A C   1 
ATOM   399  O  O   . ASN A 1 52  ? -43.45826 -33.09930 0.18769   1.000 23.57611 ?  80  ASN A O   1 
ATOM   400  C  CB  . ASN A 1 52  ? -43.66652 -36.20413 0.81299   1.000 21.65808 ?  80  ASN A CB  1 
ATOM   401  C  CG  . ASN A 1 52  ? -43.16618 -37.51326 0.23615   1.000 26.70127 ?  80  ASN A CG  1 
ATOM   402  O  OD1 . ASN A 1 52  ? -43.70860 -38.58714 0.52411   1.000 29.88961 ?  80  ASN A OD1 1 
ATOM   403  N  ND2 . ASN A 1 52  ? -42.11045 -37.43853 -0.55744  1.000 23.56707 ?  80  ASN A ND2 1 
ATOM   404  N  N   . THR A 1 53  ? -43.34219 -33.37404 2.41684   1.000 21.36722 ?  81  THR A N   1 
ATOM   405  C  CA  . THR A 1 53  ? -44.03475 -32.11916 2.66644   1.000 22.26367 ?  81  THR A CA  1 
ATOM   406  C  C   . THR A 1 53  ? -43.06647 -30.95036 2.80461   1.000 25.65897 ?  81  THR A C   1 
ATOM   407  O  O   . THR A 1 53  ? -43.46368 -29.80227 2.57563   1.000 24.74160 ?  81  THR A O   1 
ATOM   408  C  CB  . THR A 1 53  ? -44.92996 -32.27974 3.90872   1.000 20.49386 ?  81  THR A CB  1 
ATOM   409  O  OG1 . THR A 1 53  ? -45.77688 -33.41779 3.71403   1.000 22.53527 ?  81  THR A OG1 1 
ATOM   410  C  CG2 . THR A 1 53  ? -45.80818 -31.05845 4.13004   1.000 24.12358 ?  81  THR A CG2 1 
ATOM   411  N  N   . ILE A 1 54  ? -41.79488 -31.20511 3.13617   1.000 20.90154 ?  82  ILE A N   1 
ATOM   412  C  CA  . ILE A 1 54  ? -40.76778 -30.20810 2.85005   1.000 20.52729 ?  82  ILE A CA  1 
ATOM   413  C  C   . ILE A 1 54  ? -40.73555 -29.94503 1.35005   1.000 22.24431 ?  82  ILE A C   1 
ATOM   414  O  O   . ILE A 1 54  ? -40.69098 -28.79486 0.88936   1.000 24.32465 ?  82  ILE A O   1 
ATOM   415  C  CB  . ILE A 1 54  ? -39.38497 -30.67364 3.34569   1.000 20.13825 ?  82  ILE A CB  1 
ATOM   416  C  CG1 . ILE A 1 54  ? -39.31231 -30.77368 4.87850   1.000 17.51859 ?  82  ILE A CG1 1 
ATOM   417  C  CG2 . ILE A 1 54  ? -38.30261 -29.72145 2.84025   1.000 23.09504 ?  82  ILE A CG2 1 
ATOM   418  C  CD1 . ILE A 1 54  ? -38.09314 -31.57518 5.36512   1.000 20.65995 ?  82  ILE A CD1 1 
ATOM   419  N  N   . ARG A 1 55  ? -40.76360 -31.02424 0.56577   1.000 22.86984 ?  83  ARG A N   1 
ATOM   420  C  CA  . ARG A 1 55  ? -40.65228 -30.88918 -0.88260  1.000 23.86428 ?  83  ARG A CA  1 
ATOM   421  C  C   . ARG A 1 55  ? -41.81848 -30.09128 -1.45664  1.000 27.83659 ?  83  ARG A C   1 
ATOM   422  O  O   . ARG A 1 55  ? -41.62420 -29.23611 -2.32930  1.000 25.82687 ?  83  ARG A O   1 
ATOM   423  C  CB  . ARG A 1 55  ? -40.56645 -32.28283 -1.50982  1.000 22.78252 ?  83  ARG A CB  1 
ATOM   424  C  CG  . ARG A 1 55  ? -40.56172 -32.30692 -3.03953  1.000 24.04696 ?  83  ARG A CG  1 
ATOM   425  C  CD  . ARG A 1 55  ? -40.34785 -33.74355 -3.47011  1.000 26.66726 ?  83  ARG A CD  1 
ATOM   426  N  NE  . ARG A 1 55  ? -40.16332 -33.85821 -4.91162  1.000 26.58332 ?  83  ARG A NE  1 
ATOM   427  C  CZ  . ARG A 1 55  ? -39.75958 -34.96350 -5.52146  1.000 32.18969 ?  83  ARG A CZ  1 
ATOM   428  N  NH1 . ARG A 1 55  ? -39.44708 -36.05084 -4.83882  1.000 28.50833 ?  83  ARG A NH1 1 
ATOM   429  N  NH2 . ARG A 1 55  ? -39.66685 -34.97568 -6.85147  1.000 30.26284 ?  83  ARG A NH2 1 
ATOM   430  N  N   . SER A 1 56  ? -43.03581 -30.33905 -0.97230  1.000 23.33829 ?  84  SER A N   1 
ATOM   431  C  CA  . SER A 1 56  ? -44.19021 -29.64013 -1.52328  1.000 25.39138 ?  84  SER A CA  1 
ATOM   432  C  C   . SER A 1 56  ? -44.32601 -28.22027 -0.99134  1.000 28.11025 ?  84  SER A C   1 
ATOM   433  O  O   . SER A 1 56  ? -45.12020 -27.44970 -1.53784  1.000 28.74413 ?  84  SER A O   1 
ATOM   434  C  CB  . SER A 1 56  ? -45.47661 -30.43363 -1.26337  1.000 29.51409 ?  84  SER A CB  1 
ATOM   435  O  OG  . SER A 1 56  ? -45.76343 -30.52852 0.11847   1.000 29.98787 ?  84  SER A OG  1 
ATOM   436  N  N   . GLY A 1 57  ? -43.56918 -27.84941 0.03965   1.000 27.79744 ?  85  GLY A N   1 
ATOM   437  C  CA  . GLY A 1 57  ? -43.44709 -26.46271 0.44935   1.000 25.15571 ?  85  GLY A CA  1 
ATOM   438  C  C   . GLY A 1 57  ? -44.06751 -26.11430 1.78771   1.000 26.19506 ?  85  GLY A C   1 
ATOM   439  O  O   . GLY A 1 57  ? -43.81777 -25.01226 2.28868   1.000 32.18681 ?  85  GLY A O   1 
ATOM   440  N  N   . GLU A 1 58  ? -44.85857 -27.00172 2.38510   1.000 26.44611 ?  86  GLU A N   1 
ATOM   441  C  CA  . GLU A 1 58  ? -45.59468 -26.66648 3.60068   1.000 29.31838 ?  86  GLU A CA  1 
ATOM   442  C  C   . GLU A 1 58  ? -44.77448 -26.83175 4.87165   1.000 36.58181 ?  86  GLU A C   1 
ATOM   443  O  O   . GLU A 1 58  ? -45.17588 -26.30701 5.91698   1.000 35.10897 ?  86  GLU A O   1 
ATOM   444  C  CB  . GLU A 1 58  ? -46.85990 -27.52290 3.70865   1.000 31.12815 ?  86  GLU A CB  1 
ATOM   445  C  CG  . GLU A 1 58  ? -47.93027 -27.16301 2.70040   1.000 37.65899 ?  86  GLU A CG  1 
ATOM   446  C  CD  . GLU A 1 58  ? -47.72621 -27.86591 1.37459   1.000 50.14492 ?  86  GLU A CD  1 
ATOM   447  O  OE1 . GLU A 1 58  ? -47.00539 -28.88638 1.34710   1.000 51.95664 ?  86  GLU A OE1 1 
ATOM   448  O  OE2 . GLU A 1 58  ? -48.28896 -27.39976 0.35979   1.000 59.50370 ?  86  GLU A OE2 1 
ATOM   449  N  N   . LEU A 1 59  ? -43.65362 -27.55149 4.81680   1.000 23.29414 ?  87  LEU A N   1 
ATOM   450  C  CA  . LEU A 1 59  ? -42.72557 -27.66846 5.93927   1.000 23.49568 ?  87  LEU A CA  1 
ATOM   451  C  C   . LEU A 1 59  ? -41.37983 -27.09004 5.54226   1.000 27.86269 ?  87  LEU A C   1 
ATOM   452  O  O   . LEU A 1 59  ? -40.94376 -27.26242 4.40141   1.000 25.55008 ?  87  LEU A O   1 
ATOM   453  C  CB  . LEU A 1 59  ? -42.50630 -29.12353 6.35996   1.000 22.36249 ?  87  LEU A CB  1 
ATOM   454  C  CG  . LEU A 1 59  ? -43.67630 -29.89825 6.95606   1.000 21.94547 ?  87  LEU A CG  1 
ATOM   455  C  CD1 . LEU A 1 59  ? -43.20788 -31.32273 7.25861   1.000 26.16754 ?  87  LEU A CD1 1 
ATOM   456  C  CD2 . LEU A 1 59  ? -44.17294 -29.21203 8.22103   1.000 25.27428 ?  87  LEU A CD2 1 
ATOM   457  N  N   . ASP A 1 60  ? -40.71022 -26.42606 6.48335   1.000 21.59554 ?  88  ASP A N   1 
ATOM   458  C  CA  . ASP A 1 60  ? -39.35201 -25.95014 6.24040   1.000 21.52429 ?  88  ASP A CA  1 
ATOM   459  C  C   . ASP A 1 60  ? -38.29248 -26.91864 6.74374   1.000 26.03548 ?  88  ASP A C   1 
ATOM   460  O  O   . ASP A 1 60  ? -37.20728 -27.00372 6.15843   1.000 22.78636 ?  88  ASP A O   1 
ATOM   461  C  CB  . ASP A 1 60  ? -39.13699 -24.59116 6.91719   1.000 23.89039 ?  88  ASP A CB  1 
ATOM   462  C  CG  . ASP A 1 60  ? -40.18020 -23.57887 6.51359   1.000 29.51042 ?  88  ASP A CG  1 
ATOM   463  O  OD1 . ASP A 1 60  ? -40.07499 -23.05004 5.38326   1.000 33.60641 ?  88  ASP A OD1 1 
ATOM   464  O  OD2 . ASP A 1 60  ? -41.12539 -23.33764 7.29755   1.000 25.60779 ?  88  ASP A OD2 1 
ATOM   465  N  N   . PHE A 1 61  ? -38.57589 -27.61639 7.84011   1.000 20.45851 ?  89  PHE A N   1 
ATOM   466  C  CA  . PHE A 1 61  ? -37.68901 -28.61812 8.41157   1.000 20.50479 ?  89  PHE A CA  1 
ATOM   467  C  C   . PHE A 1 61  ? -38.51552 -29.84878 8.73064   1.000 20.35468 ?  89  PHE A C   1 
ATOM   468  O  O   . PHE A 1 61  ? -39.73632 -29.77847 8.85941   1.000 21.69845 ?  89  PHE A O   1 
ATOM   469  C  CB  . PHE A 1 61  ? -37.00322 -28.14242 9.70754   1.000 23.90302 ?  89  PHE A CB  1 
ATOM   470  C  CG  . PHE A 1 61  ? -36.10861 -26.94317 9.52706   1.000 20.20368 ?  89  PHE A CG  1 
ATOM   471  C  CD1 . PHE A 1 61  ? -36.63748 -25.66309 9.46814   1.000 22.81856 ?  89  PHE A CD1 1 
ATOM   472  C  CD2 . PHE A 1 61  ? -34.72843 -27.10147 9.43814   1.000 21.99533 ?  89  PHE A CD2 1 
ATOM   473  C  CE1 . PHE A 1 61  ? -35.80344 -24.56026 9.30857   1.000 23.83244 ?  89  PHE A CE1 1 
ATOM   474  C  CE2 . PHE A 1 61  ? -33.88333 -25.99850 9.28940   1.000 23.46755 ?  89  PHE A CE2 1 
ATOM   475  C  CZ  . PHE A 1 61  ? -34.42781 -24.72123 9.22017   1.000 21.48884 ?  89  PHE A CZ  1 
ATOM   476  N  N   . GLY A 1 62  ? -37.83916 -30.97012 8.89232   1.000 19.93062 ?  90  GLY A N   1 
ATOM   477  C  CA  . GLY A 1 62  ? -38.51557 -32.20301 9.25483   1.000 19.44448 ?  90  GLY A CA  1 
ATOM   478  C  C   . GLY A 1 62  ? -37.55989 -33.10059 9.99765   1.000 23.71376 ?  90  GLY A C   1 
ATOM   479  O  O   . GLY A 1 62  ? -36.35013 -33.09258 9.74274   1.000 20.99620 ?  90  GLY A O   1 
ATOM   480  N  N   . ILE A 1 63  ? -38.09565 -33.87312 10.93555  1.000 18.42045 ?  91  ILE A N   1 
ATOM   481  C  CA  . ILE A 1 63  ? -37.29105 -34.87676 11.61103  1.000 18.85707 ?  91  ILE A CA  1 
ATOM   482  C  C   . ILE A 1 63  ? -37.49725 -36.19031 10.87075  1.000 21.02831 ?  91  ILE A C   1 
ATOM   483  O  O   . ILE A 1 63  ? -38.63159 -36.61530 10.62643  1.000 19.90004 ?  91  ILE A O   1 
ATOM   484  C  CB  . ILE A 1 63  ? -37.63878 -34.97559 13.10070  1.000 17.97990 ?  91  ILE A CB  1 
ATOM   485  C  CG1 . ILE A 1 63  ? -37.50092 -33.57118 13.70546  1.000 18.51493 ?  91  ILE A CG1 1 
ATOM   486  C  CG2 . ILE A 1 63  ? -36.68884 -35.95406 13.77640  1.000 20.09549 ?  91  ILE A CG2 1 
ATOM   487  C  CD1 . ILE A 1 63  ? -37.82167 -33.47957 15.20441  1.000 19.99876 ?  91  ILE A CD1 1 
ATOM   488  N  N   . VAL A 1 64  ? -36.39386 -36.79210 10.43662  1.000 16.95004 ?  92  VAL A N   1 
ATOM   489  C  CA  . VAL A 1 64  ? -36.42983 -37.87590 9.45394   1.000 16.22748 ?  92  VAL A CA  1 
ATOM   490  C  C   . VAL A 1 64  ? -35.35853 -38.88980 9.84193   1.000 16.57565 ?  92  VAL A C   1 
ATOM   491  O  O   . VAL A 1 64  ? -34.23116 -38.50319 10.17342  1.000 19.59581 ?  92  VAL A O   1 
ATOM   492  C  CB  . VAL A 1 64  ? -36.18976 -37.32365 8.02923   1.000 20.08052 ?  92  VAL A CB  1 
ATOM   493  C  CG1 . VAL A 1 64  ? -36.08833 -38.44854 7.02999   1.000 19.50329 ?  92  VAL A CG1 1 
ATOM   494  C  CG2 . VAL A 1 64  ? -37.31606 -36.37009 7.61661   1.000 21.87850 ?  92  VAL A CG2 1 
ATOM   495  N  N   . GLN A 1 65  ? -35.70428 -40.17785 9.80805   1.000 17.89309 ?  93  GLN A N   1 
ATOM   496  C  CA  . GLN A 1 65  ? -34.72068 -41.22334 10.08805  1.000 16.35130 ?  93  GLN A CA  1 
ATOM   497  C  C   . GLN A 1 65  ? -33.57433 -41.17075 9.08390   1.000 17.30624 ?  93  GLN A C   1 
ATOM   498  O  O   . GLN A 1 65  ? -33.75124 -40.76884 7.92719   1.000 19.80698 ?  93  GLN A O   1 
ATOM   499  C  CB  . GLN A 1 65  ? -35.35826 -42.60907 10.00319  1.000 16.22803 ?  93  GLN A CB  1 
ATOM   500  C  CG  . GLN A 1 65  ? -36.47081 -42.87303 11.03728  1.000 16.49321 ?  93  GLN A CG  1 
ATOM   501  C  CD  . GLN A 1 65  ? -37.24564 -44.16721 10.78339  1.000 20.20977 ?  93  GLN A CD  1 
ATOM   502  O  OE1 . GLN A 1 65  ? -38.31920 -44.37743 11.36849  1.000 19.33561 ?  93  GLN A OE1 1 
ATOM   503  N  NE2 . GLN A 1 65  ? -36.71017 -45.04885 9.94025   1.000 20.00530 ?  93  GLN A NE2 1 
ATOM   504  N  N   . SER A 1 66  ? -32.40339 -41.64090 9.52843   1.000 19.67687 ?  94  SER A N   1 
ATOM   505  C  CA  . SER A 1 66  ? -31.22692 -41.58647 8.66794   1.000 19.85342 ?  94  SER A CA  1 
ATOM   506  C  C   . SER A 1 66  ? -31.39954 -42.44123 7.41499   1.000 23.13468 ?  94  SER A C   1 
ATOM   507  O  O   . SER A 1 66  ? -30.84755 -42.09420 6.35625   1.000 19.92684 ?  94  SER A O   1 
ATOM   508  C  CB  . SER A 1 66  ? -29.98121 -42.01140 9.45610   1.000 21.89287 ?  94  SER A CB  1 
ATOM   509  O  OG  . SER A 1 66  ? -30.16114 -43.25871 10.11195  1.000 19.92258 ?  94  SER A OG  1 
ATOM   510  N  N   . ASP A 1 67  ? -32.16182 -43.54200 7.48054   1.000 19.57869 ?  95  ASP A N   1 
ATOM   511  C  CA  . ASP A 1 67  ? -32.37877 -44.27705 6.23421   1.000 20.76301 ?  95  ASP A CA  1 
ATOM   512  C  C   . ASP A 1 67  ? -33.26257 -43.48670 5.27240   1.000 25.03231 ?  95  ASP A C   1 
ATOM   513  O  O   . ASP A 1 67  ? -32.97721 -43.43527 4.06927   1.000 21.59762 ?  95  ASP A O   1 
ATOM   514  C  CB  . ASP A 1 67  ? -32.92013 -45.70279 6.47504   1.000 18.70996 ?  95  ASP A CB  1 
ATOM   515  C  CG  . ASP A 1 67  ? -34.17130 -45.77968 7.35636   1.000 22.74033 ?  95  ASP A CG  1 
ATOM   516  O  OD1 . ASP A 1 67  ? -34.52906 -44.78854 8.02175   1.000 21.15638 ?  95  ASP A OD1 1 
ATOM   517  O  OD2 . ASP A 1 67  ? -34.76797 -46.88856 7.38507   1.000 20.34395 ?  95  ASP A OD2 1 
ATOM   518  N  N   . TRP A 1 68  ? -34.29681 -42.80045 5.77121   1.000 18.81681 ?  96  TRP A N   1 
ATOM   519  C  CA  . TRP A 1 68  ? -35.13674 -42.03813 4.84467   1.000 18.90046 ?  96  TRP A CA  1 
ATOM   520  C  C   . TRP A 1 68  ? -34.53267 -40.69012 4.45688   1.000 17.10015 ?  96  TRP A C   1 
ATOM   521  O  O   . TRP A 1 68  ? -34.91868 -40.13645 3.41716   1.000 20.31171 ?  96  TRP A O   1 
ATOM   522  C  CB  . TRP A 1 68  ? -36.57416 -41.93111 5.42380   1.000 20.45726 ?  96  TRP A CB  1 
ATOM   523  C  CG  . TRP A 1 68  ? -37.01194 -43.34058 5.69989   1.000 19.59609 ?  96  TRP A CG  1 
ATOM   524  C  CD1 . TRP A 1 68  ? -37.37649 -43.89411 6.90487   1.000 19.33316 ?  96  TRP A CD1 1 
ATOM   525  C  CD2 . TRP A 1 68  ? -36.98866 -44.42546 4.75540   1.000 18.02081 ?  96  TRP A CD2 1 
ATOM   526  N  NE1 . TRP A 1 68  ? -37.60907 -45.24857 6.75090   1.000 19.95875 ?  96  TRP A NE1 1 
ATOM   527  C  CE2 . TRP A 1 68  ? -37.37055 -45.59211 5.44107   1.000 20.10485 ?  96  TRP A CE2 1 
ATOM   528  C  CE3 . TRP A 1 68  ? -36.70169 -44.51114 3.38218   1.000 19.52662 ?  96  TRP A CE3 1 
ATOM   529  C  CZ2 . TRP A 1 68  ? -37.44151 -46.83896 4.80876   1.000 19.67232 ?  96  TRP A CZ2 1 
ATOM   530  C  CZ3 . TRP A 1 68  ? -36.78236 -45.73688 2.76345   1.000 19.61619 ?  96  TRP A CZ3 1 
ATOM   531  C  CH2 . TRP A 1 68  ? -37.15943 -46.88489 3.46617   1.000 21.91668 ?  96  TRP A CH2 1 
ATOM   532  N  N   . GLN A 1 69  ? -33.56306 -40.17859 5.22346   1.000 19.73662 ?  97  GLN A N   1 
ATOM   533  C  CA  . GLN A 1 69  ? -32.76555 -39.05515 4.73827   1.000 18.79911 ?  97  GLN A CA  1 
ATOM   534  C  C   . GLN A 1 69  ? -32.07442 -39.43606 3.43299   1.000 21.74741 ?  97  GLN A C   1 
ATOM   535  O  O   . GLN A 1 69  ? -32.14952 -38.71250 2.43195   1.000 21.02826 ?  97  GLN A O   1 
ATOM   536  C  CB  . GLN A 1 69  ? -31.72379 -38.63641 5.77707   1.000 20.85633 ?  97  GLN A CB  1 
ATOM   537  C  CG  . GLN A 1 69  ? -30.84134 -37.46968 5.30289   1.000 20.38040 ?  97  GLN A CG  1 
ATOM   538  C  CD  . GLN A 1 69  ? -29.63580 -37.20855 6.20386   1.000 23.51980 ?  97  GLN A CD  1 
ATOM   539  O  OE1 . GLN A 1 69  ? -28.48694 -37.29597 5.76708   1.000 24.04156 ?  97  GLN A OE1 1 
ATOM   540  N  NE2 . GLN A 1 69  ? -29.89042 -36.88128 7.47237   1.000 21.15410 ?  97  GLN A NE2 1 
ATOM   541  N  N   . TYR A 1 70  ? -31.40446 -40.59057 3.43924   1.000 20.55438 ?  98  TYR A N   1 
ATOM   542  C  CA  . TYR A 1 70  ? -30.68040 -41.06973 2.26343   1.000 25.14905 ?  98  TYR A CA  1 
ATOM   543  C  C   . TYR A 1 70  ? -31.62353 -41.33990 1.10307   1.000 22.15227 ?  98  TYR A C   1 
ATOM   544  O  O   . TYR A 1 70  ? -31.39225 -40.88318 -0.02666  1.000 21.19370 ?  98  TYR A O   1 
ATOM   545  C  CB  . TYR A 1 70  ? -29.91815 -42.33923 2.63349   1.000 19.32024 ?  98  TYR A CB  1 
ATOM   546  C  CG  . TYR A 1 70  ? -29.18777 -43.00688 1.47835   1.000 19.45128 ?  98  TYR A CG  1 
ATOM   547  C  CD1 . TYR A 1 70  ? -27.93726 -42.55200 1.07705   1.000 26.52911 ?  98  TYR A CD1 1 
ATOM   548  C  CD2 . TYR A 1 70  ? -29.72590 -44.11077 0.84669   1.000 20.33763 ?  98  TYR A CD2 1 
ATOM   549  C  CE1 . TYR A 1 70  ? -27.24385 -43.17855 0.02766   1.000 25.40356 ?  98  TYR A CE1 1 
ATOM   550  C  CE2 . TYR A 1 70  ? -29.04186 -44.74235 -0.22386  1.000 23.78761 ?  98  TYR A CE2 1 
ATOM   551  C  CZ  . TYR A 1 70  ? -27.80836 -44.26766 -0.60769  1.000 26.86825 ?  98  TYR A CZ  1 
ATOM   552  O  OH  . TYR A 1 70  ? -27.13271 -44.90239 -1.65027  1.000 27.10484 ?  98  TYR A OH  1 
ATOM   553  N  N   . HIS A 1 71  ? -32.68253 -42.11543 1.34712   1.000 20.00163 ?  99  HIS A N   1 
ATOM   554  C  CA  . HIS A 1 71  ? -33.57061 -42.48213 0.24810   1.000 21.25638 ?  99  HIS A CA  1 
ATOM   555  C  C   . HIS A 1 71  ? -34.43357 -41.31818 -0.22591  1.000 21.41643 ?  99  HIS A C   1 
ATOM   556  O  O   . HIS A 1 71  ? -34.82667 -41.28676 -1.40020  1.000 20.45140 ?  99  HIS A O   1 
ATOM   557  C  CB  . HIS A 1 71  ? -34.44717 -43.66429 0.64920   1.000 20.56190 ?  99  HIS A CB  1 
ATOM   558  C  CG  . HIS A 1 71  ? -33.68625 -44.94916 0.76222   1.000 21.34364 ?  99  HIS A CG  1 
ATOM   559  N  ND1 . HIS A 1 71  ? -33.08216 -45.54871 -0.32597  1.000 21.51692 ?  99  HIS A ND1 1 
ATOM   560  C  CD2 . HIS A 1 71  ? -33.41547 -45.74097 1.82767   1.000 22.47254 ?  99  HIS A CD2 1 
ATOM   561  C  CE1 . HIS A 1 71  ? -32.47746 -46.65623 0.06520   1.000 22.53836 ?  99  HIS A CE1 1 
ATOM   562  N  NE2 . HIS A 1 71  ? -32.66197 -46.79606 1.36876   1.000 22.52008 ?  99  HIS A NE2 1 
ATOM   563  N  N   . GLY A 1 72  ? -34.75311 -40.36414 0.64960   1.000 21.81173 ?  100 GLY A N   1 
ATOM   564  C  CA  . GLY A 1 72  ? -35.52207 -39.21148 0.19618   1.000 21.17665 ?  100 GLY A CA  1 
ATOM   565  C  C   . GLY A 1 72  ? -34.72784 -38.35250 -0.76998  1.000 20.75878 ?  100 GLY A C   1 
ATOM   566  O  O   . GLY A 1 72  ? -35.25150 -37.88106 -1.78208  1.000 23.97405 ?  100 GLY A O   1 
ATOM   567  N  N   . TYR A 1 73  ? -33.45673 -38.13940 -0.45782  1.000 20.02941 ?  101 TYR A N   1 
ATOM   568  C  CA  . TYR A 1 73  ? -32.55771 -37.40181 -1.33170  1.000 20.85421 ?  101 TYR A CA  1 
ATOM   569  C  C   . TYR A 1 73  ? -32.43562 -38.10178 -2.67473  1.000 23.01193 ?  101 TYR A C   1 
ATOM   570  O  O   . TYR A 1 73  ? -32.55668 -37.47078 -3.73000  1.000 24.83758 ?  101 TYR A O   1 
ATOM   571  C  CB  . TYR A 1 73  ? -31.20188 -37.29061 -0.63366  1.000 20.32526 ?  101 TYR A CB  1 
ATOM   572  C  CG  . TYR A 1 73  ? -30.09792 -36.55091 -1.36751  1.000 24.89979 ?  101 TYR A CG  1 
ATOM   573  C  CD1 . TYR A 1 73  ? -30.08605 -35.15804 -1.42530  1.000 25.95488 ?  101 TYR A CD1 1 
ATOM   574  C  CD2 . TYR A 1 73  ? -29.03602 -37.24075 -1.93510  1.000 25.26536 ?  101 TYR A CD2 1 
ATOM   575  C  CE1 . TYR A 1 73  ? -29.06607 -34.48120 -2.06203  1.000 27.96734 ?  101 TYR A CE1 1 
ATOM   576  C  CE2 . TYR A 1 73  ? -27.99772 -36.55931 -2.57738  1.000 25.73585 ?  101 TYR A CE2 1 
ATOM   577  C  CZ  . TYR A 1 73  ? -28.02656 -35.18437 -2.63407  1.000 30.84780 ?  101 TYR A CZ  1 
ATOM   578  O  OH  . TYR A 1 73  ? -27.01951 -34.47643 -3.26878  1.000 33.23062 ?  101 TYR A OH  1 
ATOM   579  N  N   . ASN A 1 74  ? -32.26963 -39.42151 -2.65079  1.000 20.70207 ?  102 ASN A N   1 
ATOM   580  C  CA  . ASN A 1 74  ? -31.96222 -40.17513 -3.86342  1.000 20.68804 ?  102 ASN A CA  1 
ATOM   581  C  C   . ASN A 1 74  ? -33.18637 -40.61477 -4.65009  1.000 26.23595 ?  102 ASN A C   1 
ATOM   582  O  O   . ASN A 1 74  ? -33.03500 -41.12197 -5.77456  1.000 24.11775 ?  102 ASN A O   1 
ATOM   583  C  CB  . ASN A 1 74  ? -31.12602 -41.40188 -3.49975  1.000 21.33539 ?  102 ASN A CB  1 
ATOM   584  C  CG  . ASN A 1 74  ? -29.68093 -41.04499 -3.25647  1.000 28.73603 ?  102 ASN A CG  1 
ATOM   585  O  OD1 . ASN A 1 74  ? -28.99640 -40.58988 -4.17107  1.000 28.63825 ?  102 ASN A OD1 1 
ATOM   586  N  ND2 . ASN A 1 74  ? -29.21407 -41.20710 -2.02285  1.000 25.28855 ?  102 ASN A ND2 1 
ATOM   587  N  N   . GLY A 1 75  ? -34.38548 -40.45263 -4.10060  1.000 22.91237 ?  103 GLY A N   1 
ATOM   588  C  CA  . GLY A 1 75  ? -35.57439 -40.94136 -4.77519  1.000 20.61942 ?  103 GLY A CA  1 
ATOM   589  C  C   . GLY A 1 75  ? -35.61357 -42.44567 -4.92714  1.000 22.42160 ?  103 GLY A C   1 
ATOM   590  O  O   . GLY A 1 75  ? -36.02749 -42.94945 -5.97890  1.000 24.63978 ?  103 GLY A O   1 
ATOM   591  N  N   . THR A 1 76  ? -35.22478 -43.17672 -3.88734  1.000 22.18627 ?  104 THR A N   1 
ATOM   592  C  CA  . THR A 1 76  ? -35.13740 -44.62404 -3.93888  1.000 21.75591 ?  104 THR A CA  1 
ATOM   593  C  C   . THR A 1 76  ? -36.01055 -45.24771 -2.85491  1.000 25.67567 ?  104 THR A C   1 
ATOM   594  O  O   . THR A 1 76  ? -36.45629 -44.56664 -1.92520  1.000 21.72014 ?  104 THR A O   1 
ATOM   595  C  CB  . THR A 1 76  ? -33.67425 -45.07500 -3.79383  1.000 22.24672 ?  104 THR A CB  1 
ATOM   596  O  OG1 . THR A 1 76  ? -33.02224 -44.31614 -2.76872  1.000 21.11233 ?  104 THR A OG1 1 
ATOM   597  C  CG2 . THR A 1 76  ? -32.93522 -44.85234 -5.09664  1.000 21.66972 ?  104 THR A CG2 1 
ATOM   598  N  N   . SER A 1 77  ? -36.27602 -46.54748 -3.01107  1.000 20.84930 ?  105 SER A N   1 
ATOM   599  C  CA  . SER A 1 77  ? -37.00424 -47.35112 -2.01857  1.000 20.88741 ?  105 SER A CA  1 
ATOM   600  C  C   . SER A 1 77  ? -38.39502 -46.75182 -1.85386  1.000 22.46548 ?  105 SER A C   1 
ATOM   601  O  O   . SER A 1 77  ? -39.11819 -46.63178 -2.85720  1.000 21.72719 ?  105 SER A O   1 
ATOM   602  C  CB  . SER A 1 77  ? -36.16454 -47.43000 -0.74113  1.000 21.60768 ?  105 SER A CB  1 
ATOM   603  O  OG  . SER A 1 77  ? -36.82605 -48.20801 0.26213   1.000 23.59267 ?  105 SER A OG  1 
ATOM   604  N  N   . GLU A 1 78  ? -38.81043 -46.35637 -0.63939  1.000 21.56231 ?  106 GLU A N   1 
ATOM   605  C  CA  . GLU A 1 78  ? -40.14790 -45.79980 -0.45020  1.000 21.10694 ?  106 GLU A CA  1 
ATOM   606  C  C   . GLU A 1 78  ? -40.38944 -44.56321 -1.31231  1.000 25.22582 ?  106 GLU A C   1 
ATOM   607  O  O   . GLU A 1 78  ? -41.53878 -44.26788 -1.66898  1.000 26.96121 ?  106 GLU A O   1 
ATOM   608  C  CB  . GLU A 1 78  ? -40.36375 -45.48302 1.04205   1.000 19.51395 ?  106 GLU A CB  1 
ATOM   609  C  CG  . GLU A 1 78  ? -41.50178 -44.47477 1.29964   1.000 24.56374 ?  106 GLU A CG  1 
ATOM   610  C  CD  . GLU A 1 78  ? -42.88939 -45.05703 1.01035   1.000 36.18937 ?  106 GLU A CD  1 
ATOM   611  O  OE1 . GLU A 1 78  ? -43.04614 -46.29558 1.04295   1.000 37.00676 ?  106 GLU A OE1 1 
ATOM   612  O  OE2 . GLU A 1 78  ? -43.81845 -44.27070 0.71554   1.000 37.02484 ?  106 GLU A OE2 1 
ATOM   613  N  N   . PHE A 1 79  ? -39.33657 -43.83551 -1.66945  1.000 21.15728 ?  107 PHE A N   1 
ATOM   614  C  CA  . PHE A 1 79  ? -39.48449 -42.61839 -2.44644  1.000 18.46680 ?  107 PHE A CA  1 
ATOM   615  C  C   . PHE A 1 79  ? -39.36449 -42.84390 -3.94985  1.000 22.43719 ?  107 PHE A C   1 
ATOM   616  O  O   . PHE A 1 79  ? -39.28059 -41.86526 -4.69136  1.000 24.64057 ?  107 PHE A O   1 
ATOM   617  C  CB  . PHE A 1 79  ? -38.44837 -41.57975 -2.01205  1.000 20.60766 ?  107 PHE A CB  1 
ATOM   618  C  CG  . PHE A 1 79  ? -38.63164 -41.08596 -0.59249  1.000 22.68513 ?  107 PHE A CG  1 
ATOM   619  C  CD1 . PHE A 1 79  ? -39.56839 -40.09968 -0.30655  1.000 23.35174 ?  107 PHE A CD1 1 
ATOM   620  C  CD2 . PHE A 1 79  ? -37.86448 -41.60389 0.44215   1.000 22.18209 ?  107 PHE A CD2 1 
ATOM   621  C  CE1 . PHE A 1 79  ? -39.73479 -39.62808 0.98977   1.000 17.88954 ?  107 PHE A CE1 1 
ATOM   622  C  CE2 . PHE A 1 79  ? -38.01767 -41.14522 1.77284   1.000 20.33933 ?  107 PHE A CE2 1 
ATOM   623  C  CZ  . PHE A 1 79  ? -38.95697 -40.15436 2.04758   1.000 19.24335 ?  107 PHE A CZ  1 
ATOM   624  N  N   . ALA A 1 80  ? -39.35897 -44.09522 -4.41576  1.000 24.52266 ?  108 ALA A N   1 
ATOM   625  C  CA  . ALA A 1 80  ? -39.07473 -44.33088 -5.83466  1.000 24.08854 ?  108 ALA A CA  1 
ATOM   626  C  C   . ALA A 1 80  ? -40.10810 -43.66764 -6.73722  1.000 27.83725 ?  108 ALA A C   1 
ATOM   627  O  O   . ALA A 1 80  ? -39.75030 -43.08394 -7.77195  1.000 25.36542 ?  108 ALA A O   1 
ATOM   628  C  CB  . ALA A 1 80  ? -38.99784 -45.83094 -6.12795  1.000 22.69449 ?  108 ALA A CB  1 
ATOM   629  N  N   . GLU A 1 81  ? -41.39175 -43.73604 -6.36828  1.000 25.43361 ?  109 GLU A N   1 
ATOM   630  C  CA  . GLU A 1 81  ? -42.41595 -43.14718 -7.23205  1.000 28.20662 ?  109 GLU A CA  1 
ATOM   631  C  C   . GLU A 1 81  ? -42.33310 -41.62649 -7.23266  1.000 32.16992 ?  109 GLU A C   1 
ATOM   632  O  O   . GLU A 1 81  ? -42.67075 -40.98324 -8.22928  1.000 33.83935 ?  109 GLU A O   1 
ATOM   633  C  CB  . GLU A 1 81  ? -43.80685 -43.61331 -6.80529  1.000 31.02702 ?  109 GLU A CB  1 
ATOM   634  N  N   . GLN A 1 82  ? -41.85948 -41.03922 -6.14191  1.000 27.79798 ?  110 GLN A N   1 
ATOM   635  C  CA  A GLN A 1 82  ? -41.76351 -39.58799 -6.01100  0.848 28.49820 ?  110 GLN A CA  1 
ATOM   636  C  CA  B GLN A 1 82  ? -41.80509 -39.58902 -6.07637  0.152 28.58494 ?  110 GLN A CA  1 
ATOM   637  C  C   . GLN A 1 82  ? -40.60058 -39.01773 -6.81533  1.000 28.69305 ?  110 GLN A C   1 
ATOM   638  O  O   . GLN A 1 82  ? -40.62070 -37.83835 -7.19024  1.000 29.96810 ?  110 GLN A O   1 
ATOM   639  C  CB  A GLN A 1 82  ? -41.59407 -39.20570 -4.52851  0.848 29.58811 ?  110 GLN A CB  1 
ATOM   640  C  CB  B GLN A 1 82  ? -41.82516 -39.17895 -4.60590  0.152 30.18357 ?  110 GLN A CB  1 
ATOM   641  C  CG  A GLN A 1 82  ? -42.83850 -39.40185 -3.64165  0.848 35.63682 ?  110 GLN A CG  1 
ATOM   642  C  CG  B GLN A 1 82  ? -43.15626 -39.57044 -3.97736  0.152 34.49611 ?  110 GLN A CG  1 
ATOM   643  C  CD  A GLN A 1 82  ? -43.38121 -40.83494 -3.60703  0.848 41.23224 ?  110 GLN A CD  1 
ATOM   644  C  CD  B GLN A 1 82  ? -43.18746 -39.40871 -2.48274  0.152 33.98617 ?  110 GLN A CD  1 
ATOM   645  O  OE1 A GLN A 1 82  ? -42.63764 -41.80256 -3.40102  0.848 33.16220 ?  110 GLN A OE1 1 
ATOM   646  O  OE1 B GLN A 1 82  ? -42.15350 -39.47263 -1.82123  0.152 29.79744 ?  110 GLN A OE1 1 
ATOM   647  N  NE2 A GLN A 1 82  ? -44.69179 -40.97237 -3.81210  0.848 45.40898 ?  110 GLN A NE2 1 
ATOM   648  N  NE2 B GLN A 1 82  ? -44.38092 -39.21889 -1.93258  0.152 35.84008 ?  110 GLN A NE2 1 
ATOM   649  N  N   . GLY A 1 83  ? -39.57540 -39.82744 -7.06509  1.000 27.35848 ?  111 GLY A N   1 
ATOM   650  C  CA  . GLY A 1 83  ? -38.38278 -39.35983 -7.72652  1.000 26.91199 ?  111 GLY A CA  1 
ATOM   651  C  C   . GLY A 1 83  ? -37.42913 -38.68898 -6.75874  1.000 26.96119 ?  111 GLY A C   1 
ATOM   652  O  O   . GLY A 1 83  ? -37.77282 -38.40032 -5.60252  1.000 26.82780 ?  111 GLY A O   1 
ATOM   653  N  N   . PRO A 1 84  ? -36.20260 -38.43838 -7.21297  1.000 26.22179 ?  112 PRO A N   1 
ATOM   654  C  CA  . PRO A 1 84  ? -35.20043 -37.82497 -6.33743  1.000 26.41811 ?  112 PRO A CA  1 
ATOM   655  C  C   . PRO A 1 84  ? -35.63833 -36.44902 -5.85897  1.000 28.05111 ?  112 PRO A C   1 
ATOM   656  O  O   . PRO A 1 84  ? -36.36872 -35.72973 -6.54514  1.000 28.03106 ?  112 PRO A O   1 
ATOM   657  C  CB  . PRO A 1 84  ? -33.95467 -37.72854 -7.22932  1.000 31.21033 ?  112 PRO A CB  1 
ATOM   658  C  CG  . PRO A 1 84  ? -34.18535 -38.68409 -8.34549  1.000 27.52529 ?  112 PRO A CG  1 
ATOM   659  C  CD  . PRO A 1 84  ? -35.65882 -38.82474 -8.52934  1.000 27.56903 ?  112 PRO A CD  1 
ATOM   660  N  N   . TYR A 1 85  ? -35.19385 -36.09030 -4.64933  1.000 26.72272 ?  113 TYR A N   1 
ATOM   661  C  CA  . TYR A 1 85  ? -35.36681 -34.73541 -4.11952  1.000 25.07294 ?  113 TYR A CA  1 
ATOM   662  C  C   . TYR A 1 85  ? -33.97360 -34.24631 -3.72730  1.000 26.05322 ?  113 TYR A C   1 
ATOM   663  O  O   . TYR A 1 85  ? -33.57989 -34.25380 -2.55843  1.000 24.52020 ?  113 TYR A O   1 
ATOM   664  C  CB  . TYR A 1 85  ? -36.36385 -34.69464 -2.93939  1.000 23.43194 ?  113 TYR A CB  1 
ATOM   665  C  CG  . TYR A 1 85  ? -36.64438 -33.28128 -2.49258  1.000 23.88221 ?  113 TYR A CG  1 
ATOM   666  C  CD1 . TYR A 1 85  ? -36.93884 -32.29070 -3.41777  1.000 26.53369 ?  113 TYR A CD1 1 
ATOM   667  C  CD2 . TYR A 1 85  ? -36.58198 -32.92567 -1.15177  1.000 27.98139 ?  113 TYR A CD2 1 
ATOM   668  C  CE1 . TYR A 1 85  ? -37.18174 -30.97283 -3.01404  1.000 28.84027 ?  113 TYR A CE1 1 
ATOM   669  C  CE2 . TYR A 1 85  ? -36.82562 -31.61144 -0.73948  1.000 30.00283 ?  113 TYR A CE2 1 
ATOM   670  C  CZ  . TYR A 1 85  ? -37.12463 -30.64796 -1.67285  1.000 32.50509 ?  113 TYR A CZ  1 
ATOM   671  O  OH  . TYR A 1 85  ? -37.35975 -29.34875 -1.26748  1.000 33.23396 ?  113 TYR A OH  1 
ATOM   672  N  N   . LYS A 1 86  ? -33.20380 -33.82627 -4.73026  1.000 24.89196 ?  114 LYS A N   1 
ATOM   673  C  CA  . LYS A 1 86  ? -31.80730 -33.48132 -4.51751  1.000 25.79251 ?  114 LYS A CA  1 
ATOM   674  C  C   . LYS A 1 86  ? -31.62210 -32.12569 -3.85039  1.000 26.66810 ?  114 LYS A C   1 
ATOM   675  O  O   . LYS A 1 86  ? -30.48164 -31.75129 -3.55324  1.000 28.35096 ?  114 LYS A O   1 
ATOM   676  C  CB  . LYS A 1 86  ? -31.06129 -33.53759 -5.86144  1.000 28.04579 ?  114 LYS A CB  1 
ATOM   677  C  CG  . LYS A 1 86  ? -30.82379 -34.96576 -6.34892  1.000 30.44824 ?  114 LYS A CG  1 
ATOM   678  C  CD  . LYS A 1 86  ? -29.92674 -35.73506 -5.38880  1.000 27.49614 ?  114 LYS A CD  1 
ATOM   679  C  CE  . LYS A 1 86  ? -29.70242 -37.18876 -5.80869  1.000 37.31796 ?  114 LYS A CE  1 
ATOM   680  N  NZ  . LYS A 1 86  ? -29.18442 -37.32936 -7.20611  1.000 32.02775 ?  114 LYS A NZ  1 
ATOM   681  N  N   . LYS A 1 87  ? -32.70546 -31.39290 -3.58891  1.000 24.95453 ?  115 LYS A N   1 
ATOM   682  C  CA  . LYS A 1 87  ? -32.61899 -30.20544 -2.74597  1.000 24.41544 ?  115 LYS A CA  1 
ATOM   683  C  C   . LYS A 1 87  ? -32.62416 -30.52725 -1.25135  1.000 25.60932 ?  115 LYS A C   1 
ATOM   684  O  O   . LYS A 1 87  ? -32.35797 -29.62946 -0.44784  1.000 24.18830 ?  115 LYS A O   1 
ATOM   685  C  CB  . LYS A 1 87  ? -33.76414 -29.24876 -3.06478  1.000 27.72795 ?  115 LYS A CB  1 
ATOM   686  C  CG  . LYS A 1 87  ? -33.71441 -28.69290 -4.48135  1.000 29.84241 ?  115 LYS A CG  1 
ATOM   687  C  CD  . LYS A 1 87  ? -34.90610 -27.78784 -4.72371  1.000 33.27203 ?  115 LYS A CD  1 
ATOM   688  C  CE  . LYS A 1 87  ? -34.82296 -27.12076 -6.09246  1.000 42.16615 ?  115 LYS A CE  1 
ATOM   689  N  NZ  . LYS A 1 87  ? -35.85833 -26.06089 -6.23011  1.000 52.09712 ?  115 LYS A NZ  1 
ATOM   690  N  N   . LEU A 1 88  ? -32.90398 -31.76731 -0.85795  1.000 22.83387 ?  116 LEU A N   1 
ATOM   691  C  CA  . LEU A 1 88  ? -32.89620 -32.09100 0.56766   1.000 21.78854 ?  116 LEU A CA  1 
ATOM   692  C  C   . LEU A 1 88  ? -31.50092 -31.87242 1.14588   1.000 24.16928 ?  116 LEU A C   1 
ATOM   693  O  O   . LEU A 1 88  ? -30.48876 -32.16323 0.50226   1.000 24.16818 ?  116 LEU A O   1 
ATOM   694  C  CB  . LEU A 1 88  ? -33.36097 -33.53756 0.78500   1.000 20.90401 ?  116 LEU A CB  1 
ATOM   695  C  CG  . LEU A 1 88  ? -33.88450 -33.92023 2.19042   1.000 21.36124 ?  116 LEU A CG  1 
ATOM   696  C  CD1 . LEU A 1 88  ? -35.22596 -33.21524 2.47922   1.000 20.73762 ?  116 LEU A CD1 1 
ATOM   697  C  CD2 . LEU A 1 88  ? -34.05716 -35.42606 2.27856   1.000 21.57756 ?  116 LEU A CD2 1 
ATOM   698  N  N   . ARG A 1 89  ? -31.43767 -31.33120 2.36241   1.000 21.24707 ?  117 ARG A N   1 
ATOM   699  C  CA  . ARG A 1 89  ? -30.17104 -31.07588 3.03700   1.000 22.34910 ?  117 ARG A CA  1 
ATOM   700  C  C   . ARG A 1 89  ? -30.25967 -31.54944 4.47276   1.000 24.21550 ?  117 ARG A C   1 
ATOM   701  O  O   . ARG A 1 89  ? -31.31722 -31.44866 5.09499   1.000 24.05483 ?  117 ARG A O   1 
ATOM   702  C  CB  . ARG A 1 89  ? -29.79863 -29.58913 3.05808   1.000 22.35567 ?  117 ARG A CB  1 
ATOM   703  C  CG  . ARG A 1 89  ? -29.52257 -29.01888 1.65869   1.000 21.80841 ?  117 ARG A CG  1 
ATOM   704  C  CD  . ARG A 1 89  ? -28.18200 -29.50354 1.14718   1.000 26.16158 ?  117 ARG A CD  1 
ATOM   705  N  NE  . ARG A 1 89  ? -27.92953 -28.94775 -0.17697  1.000 30.07980 ?  117 ARG A NE  1 
ATOM   706  C  CZ  . ARG A 1 89  ? -28.38430 -29.47334 -1.30938  1.000 32.44649 ?  117 ARG A CZ  1 
ATOM   707  N  NH1 . ARG A 1 89  ? -29.07460 -30.60791 -1.32337  1.000 27.86039 ?  117 ARG A NH1 1 
ATOM   708  N  NH2 . ARG A 1 89  ? -28.14384 -28.84434 -2.45967  1.000 31.90505 ?  117 ARG A NH2 1 
ATOM   709  N  N   . ALA A 1 90  ? -29.15022 -32.07050 4.98666   1.000 20.24027 ?  118 ALA A N   1 
ATOM   710  C  CA  . ALA A 1 90  ? -29.06333 -32.41679 6.39883   1.000 21.18531 ?  118 ALA A CA  1 
ATOM   711  C  C   . ALA A 1 90  ? -28.73478 -31.17958 7.22045   1.000 23.89516 ?  118 ALA A C   1 
ATOM   712  O  O   . ALA A 1 90  ? -28.13763 -30.22096 6.72286   1.000 24.12495 ?  118 ALA A O   1 
ATOM   713  C  CB  . ALA A 1 90  ? -28.00115 -33.49438 6.63957   1.000 22.66092 ?  118 ALA A CB  1 
ATOM   714  N  N   . VAL A 1 91  ? -29.13730 -31.20247 8.49686   1.000 19.41733 ?  119 VAL A N   1 
ATOM   715  C  CA  . VAL A 1 91  ? -28.77262 -30.11963 9.41223   1.000 22.42557 ?  119 VAL A CA  1 
ATOM   716  C  C   . VAL A 1 91  ? -27.91842 -30.67595 10.54222  1.000 22.26867 ?  119 VAL A C   1 
ATOM   717  O  O   . VAL A 1 91  ? -26.76541 -30.27617 10.70241  1.000 24.21495 ?  119 VAL A O   1 
ATOM   718  C  CB  . VAL A 1 91  ? -30.00487 -29.38070 9.97397   1.000 20.59707 ?  119 VAL A CB  1 
ATOM   719  C  CG1 . VAL A 1 91  ? -29.54318 -28.16882 10.79155  1.000 21.38665 ?  119 VAL A CG1 1 
ATOM   720  C  CG2 . VAL A 1 91  ? -30.92828 -28.92454 8.83452   1.000 23.48729 ?  119 VAL A CG2 1 
ATOM   721  N  N   . PHE A 1 92  ? -28.48188 -31.57570 11.34758  1.000 20.60337 ?  120 PHE A N   1 
ATOM   722  C  CA  . PHE A 1 92  ? -27.72225 -32.34917 12.32446  1.000 20.51753 ?  120 PHE A CA  1 
ATOM   723  C  C   . PHE A 1 92  ? -28.51710 -33.61161 12.62321  1.000 22.25610 ?  120 PHE A C   1 
ATOM   724  O  O   . PHE A 1 92  ? -29.70759 -33.69268 12.31751  1.000 21.98017 ?  120 PHE A O   1 
ATOM   725  C  CB  . PHE A 1 92  ? -27.43352 -31.56409 13.62639  1.000 22.55922 ?  120 PHE A CB  1 
ATOM   726  C  CG  . PHE A 1 92  ? -28.63623 -30.84450 14.20218  1.000 24.23639 ?  120 PHE A CG  1 
ATOM   727  C  CD1 . PHE A 1 92  ? -29.58066 -31.53431 14.96943  1.000 24.25624 ?  120 PHE A CD1 1 
ATOM   728  C  CD2 . PHE A 1 92  ? -28.81361 -29.47989 13.99208  1.000 21.76659 ?  120 PHE A CD2 1 
ATOM   729  C  CE1 . PHE A 1 92  ? -30.69662 -30.86491 15.49475  1.000 24.46434 ?  120 PHE A CE1 1 
ATOM   730  C  CE2 . PHE A 1 92  ? -29.92768 -28.81233 14.51416  1.000 25.87834 ?  120 PHE A CE2 1 
ATOM   731  C  CZ  . PHE A 1 92  ? -30.85939 -29.51512 15.26809  1.000 21.45060 ?  120 PHE A CZ  1 
ATOM   732  N  N   . SER A 1 93  ? -27.85051 -34.58783 13.23257  1.000 19.87936 ?  121 SER A N   1 
ATOM   733  C  CA  . SER A 1 93  ? -28.50462 -35.80259 13.69904  1.000 19.98642 ?  121 SER A CA  1 
ATOM   734  C  C   . SER A 1 93  ? -28.69316 -35.72138 15.20659  1.000 21.55723 ?  121 SER A C   1 
ATOM   735  O  O   . SER A 1 93  ? -28.16172 -34.82912 15.86273  1.000 23.04795 ?  121 SER A O   1 
ATOM   736  C  CB  . SER A 1 93  ? -27.68854 -37.04165 13.33773  1.000 22.87086 ?  121 SER A CB  1 
ATOM   737  O  OG  . SER A 1 93  ? -26.42334 -37.01108 13.98134  1.000 21.88654 ?  121 SER A OG  1 
ATOM   738  N  N   . MET A 1 94  ? -29.44870 -36.67626 15.75293  1.000 21.28791 ?  122 MET A N   1 
ATOM   739  C  CA  . MET A 1 94  ? -29.86220 -36.59913 17.15092  1.000 19.31990 ?  122 MET A CA  1 
ATOM   740  C  C   . MET A 1 94  ? -29.79705 -37.99572 17.77302  1.000 22.17728 ?  122 MET A C   1 
ATOM   741  O  O   . MET A 1 94  ? -28.78514 -38.69510 17.61844  1.000 22.28878 ?  122 MET A O   1 
ATOM   742  C  CB  . MET A 1 94  ? -31.26181 -35.98405 17.16124  1.000 23.35476 ?  122 MET A CB  1 
ATOM   743  C  CG  . MET A 1 94  ? -31.18767 -34.47536 17.11942  1.000 24.53300 ?  122 MET A CG  1 
ATOM   744  S  SD  . MET A 1 94  ? -32.79560 -33.67850 16.95295  1.000 24.39190 ?  122 MET A SD  1 
ATOM   745  C  CE  . MET A 1 94  ? -33.35250 -34.35473 15.39701  1.000 22.90457 ?  122 MET A CE  1 
ATOM   746  N  N   . HIS A 1 95  ? -30.86469 -38.43600 18.45005  1.000 20.28882 ?  123 HIS A N   1 
ATOM   747  C  CA  . HIS A 1 95  ? -30.85368 -39.69533 19.18013  1.000 18.21406 ?  123 HIS A CA  1 
ATOM   748  C  C   . HIS A 1 95  ? -30.99085 -40.90833 18.26172  1.000 19.63213 ?  123 HIS A C   1 
ATOM   749  O  O   . HIS A 1 95  ? -31.41207 -40.81448 17.10438  1.000 21.35039 ?  123 HIS A O   1 
ATOM   750  C  CB  . HIS A 1 95  ? -32.00616 -39.72899 20.18606  1.000 18.65415 ?  123 HIS A CB  1 
ATOM   751  C  CG  . HIS A 1 95  ? -33.33009 -39.46505 19.55094  1.000 18.50193 ?  123 HIS A CG  1 
ATOM   752  N  ND1 . HIS A 1 95  ? -33.72056 -38.20807 19.14635  1.000 19.48665 ?  123 HIS A ND1 1 
ATOM   753  C  CD2 . HIS A 1 95  ? -34.34164 -40.30540 19.21047  1.000 19.43106 ?  123 HIS A CD2 1 
ATOM   754  C  CE1 . HIS A 1 95  ? -34.91786 -38.28021 18.58998  1.000 20.72671 ?  123 HIS A CE1 1 
ATOM   755  N  NE2 . HIS A 1 95  ? -35.31356 -39.54197 18.61809  1.000 20.23680 ?  123 HIS A NE2 1 
ATOM   756  N  N   . THR A 1 96  ? -30.63464 -42.06137 18.81972  1.000 19.68033 ?  124 THR A N   1 
ATOM   757  C  CA  . THR A 1 96  ? -30.81997 -43.35258 18.16724  1.000 20.64159 ?  124 THR A CA  1 
ATOM   758  C  C   . THR A 1 96  ? -32.27479 -43.79655 18.25454  1.000 23.34455 ?  124 THR A C   1 
ATOM   759  O  O   . THR A 1 96  ? -32.93947 -43.58450 19.27695  1.000 23.22087 ?  124 THR A O   1 
ATOM   760  C  CB  . THR A 1 96  ? -29.92523 -44.39248 18.83478  1.000 24.86511 ?  124 THR A CB  1 
ATOM   761  O  OG1 . THR A 1 96  ? -28.56620 -43.97229 18.68260  1.000 26.61366 ?  124 THR A OG1 1 
ATOM   762  C  CG2 . THR A 1 96  ? -30.11836 -45.76379 18.21569  1.000 22.14312 ?  124 THR A CG2 1 
ATOM   763  N  N   . GLU A 1 97  ? -32.76031 -44.42256 17.17992  1.000 19.11131 ?  125 GLU A N   1 
ATOM   764  C  CA  . GLU A 1 97  ? -34.11977 -44.96801 17.13145  1.000 16.75752 ?  125 GLU A CA  1 
ATOM   765  C  C   . GLU A 1 97  ? -34.07145 -46.45628 16.80752  1.000 18.67554 ?  125 GLU A C   1 
ATOM   766  O  O   . GLU A 1 97  ? -33.97385 -46.82951 15.62433  1.000 18.94533 ?  125 GLU A O   1 
ATOM   767  C  CB  . GLU A 1 97  ? -34.96669 -44.24999 16.07377  1.000 17.22373 ?  125 GLU A CB  1 
ATOM   768  C  CG  . GLU A 1 97  ? -34.91428 -42.74231 16.10705  1.000 17.92748 ?  125 GLU A CG  1 
ATOM   769  C  CD  . GLU A 1 97  ? -35.88848 -42.16973 15.11646  1.000 19.05965 ?  125 GLU A CD  1 
ATOM   770  O  OE1 . GLU A 1 97  ? -37.10988 -42.23471 15.39895  1.000 19.86122 ?  125 GLU A OE1 1 
ATOM   771  O  OE2 . GLU A 1 97  ? -35.46188 -41.69005 14.04129  1.000 19.64414 ?  125 GLU A OE2 1 
ATOM   772  N  N   . PRO A 1 98  ? -34.17195 -47.34187 17.79334  1.000 17.87665 ?  126 PRO A N   1 
ATOM   773  C  CA  . PRO A 1 98  ? -34.26654 -48.77537 17.50103  1.000 18.79330 ?  126 PRO A CA  1 
ATOM   774  C  C   . PRO A 1 98  ? -35.57920 -49.14114 16.82230  1.000 19.45259 ?  126 PRO A C   1 
ATOM   775  O  O   . PRO A 1 98  ? -36.59253 -48.44236 16.91668  1.000 18.98997 ?  126 PRO A O   1 
ATOM   776  C  CB  . PRO A 1 98  ? -34.17086 -49.42846 18.88812  1.000 19.25388 ?  126 PRO A CB  1 
ATOM   777  C  CG  . PRO A 1 98  ? -33.48301 -48.38383 19.74264  1.000 21.18916 ?  126 PRO A CG  1 
ATOM   778  C  CD  . PRO A 1 98  ? -34.06589 -47.09239 19.23918  1.000 18.54923 ?  126 PRO A CD  1 
ATOM   779  N  N   . PHE A 1 99  ? -35.52340 -50.25794 16.09369  1.000 19.53812 ?  127 PHE A N   1 
ATOM   780  C  CA  . PHE A 1 99  ? -36.69948 -50.96692 15.59321  1.000 19.72922 ?  127 PHE A CA  1 
ATOM   781  C  C   . PHE A 1 99  ? -37.28965 -51.71460 16.78489  1.000 18.98659 ?  127 PHE A C   1 
ATOM   782  O  O   . PHE A 1 99  ? -36.80339 -52.77893 17.16870  1.000 21.94471 ?  127 PHE A O   1 
ATOM   783  C  CB  . PHE A 1 99  ? -36.28282 -51.90706 14.46119  1.000 19.67474 ?  127 PHE A CB  1 
ATOM   784  C  CG  . PHE A 1 99  ? -37.36906 -52.83941 13.97956  1.000 22.25565 ?  127 PHE A CG  1 
ATOM   785  C  CD1 . PHE A 1 99  ? -38.44192 -52.35384 13.25605  1.000 23.35046 ?  127 PHE A CD1 1 
ATOM   786  C  CD2 . PHE A 1 99  ? -37.28263 -54.20658 14.21722  1.000 22.83967 ?  127 PHE A CD2 1 
ATOM   787  C  CE1 . PHE A 1 99  ? -39.43175 -53.21182 12.79627  1.000 26.39451 ?  127 PHE A CE1 1 
ATOM   788  C  CE2 . PHE A 1 99  ? -38.27059 -55.08008 13.76949  1.000 23.71961 ?  127 PHE A CE2 1 
ATOM   789  C  CZ  . PHE A 1 99  ? -39.34940 -54.58083 13.05658  1.000 23.76376 ?  127 PHE A CZ  1 
ATOM   790  N  N   . ASN A 1 100 ? -38.31591 -51.14475 17.40511  1.000 20.34933 ?  128 ASN A N   1 
ATOM   791  C  CA  . ASN A 1 100 ? -38.89884 -51.73340 18.60458  1.000 18.43416 ?  128 ASN A CA  1 
ATOM   792  C  C   . ASN A 1 100 ? -40.10918 -52.56986 18.21875  1.000 21.08623 ?  128 ASN A C   1 
ATOM   793  O  O   . ASN A 1 100 ? -40.91582 -52.14966 17.38372  1.000 21.46364 ?  128 ASN A O   1 
ATOM   794  C  CB  . ASN A 1 100 ? -39.32843 -50.65692 19.59516  1.000 18.39097 ?  128 ASN A CB  1 
ATOM   795  C  CG  . ASN A 1 100 ? -38.19869 -49.69623 19.93896  1.000 19.16918 ?  128 ASN A CG  1 
ATOM   796  O  OD1 . ASN A 1 100 ? -37.23660 -50.07400 20.59233  1.000 22.31412 ?  128 ASN A OD1 1 
ATOM   797  N  ND2 . ASN A 1 100 ? -38.31573 -48.44957 19.48114  1.000 19.46244 ?  128 ASN A ND2 1 
ATOM   798  N  N   . ILE A 1 101 ? -40.23152 -53.74604 18.83984  1.000 21.50870 ?  129 ILE A N   1 
ATOM   799  C  CA  . ILE A 1 101 ? -41.42703 -54.59197 18.74037  1.000 19.12771 ?  129 ILE A CA  1 
ATOM   800  C  C   . ILE A 1 101 ? -42.08920 -54.58757 20.11148  1.000 21.31183 ?  129 ILE A C   1 
ATOM   801  O  O   . ILE A 1 101 ? -41.45013 -54.96208 21.09938  1.000 24.58960 ?  129 ILE A O   1 
ATOM   802  C  CB  . ILE A 1 101 ? -41.06665 -56.02481 18.33053  1.000 19.34485 ?  129 ILE A CB  1 
ATOM   803  C  CG1 . ILE A 1 101 ? -40.37262 -56.05553 16.96151  1.000 19.98567 ?  129 ILE A CG1 1 
ATOM   804  C  CG2 . ILE A 1 101 ? -42.31593 -56.93382 18.37711  1.000 23.40205 ?  129 ILE A CG2 1 
ATOM   805  C  CD1 . ILE A 1 101 ? -39.68600 -57.39557 16.68075  1.000 20.27957 ?  129 ILE A CD1 1 
ATOM   806  N  N   . ILE A 1 102 ? -43.34651 -54.14949 20.18158  1.000 19.38077 ?  130 ILE A N   1 
ATOM   807  C  CA  . ILE A 1 102 ? -44.09516 -54.09079 21.43997  1.000 20.54402 ?  130 ILE A CA  1 
ATOM   808  C  C   . ILE A 1 102 ? -45.25476 -55.07659 21.30630  1.000 24.85381 ?  130 ILE A C   1 
ATOM   809  O  O   . ILE A 1 102 ? -46.16321 -54.86196 20.49303  1.000 23.64513 ?  130 ILE A O   1 
ATOM   810  C  CB  . ILE A 1 102 ? -44.60372 -52.67829 21.74031  1.000 21.26264 ?  130 ILE A CB  1 
ATOM   811  C  CG1 . ILE A 1 102 ? -43.44301 -51.68892 21.84828  1.000 22.53557 ?  130 ILE A CG1 1 
ATOM   812  C  CG2 . ILE A 1 102 ? -45.35771 -52.65299 23.07368  1.000 20.93259 ?  130 ILE A CG2 1 
ATOM   813  C  CD1 . ILE A 1 102 ? -42.98332 -51.10737 20.50372  1.000 21.73983 ?  130 ILE A CD1 1 
ATOM   814  N  N   . ALA A 1 103 ? -45.22472 -56.15282 22.08845  1.000 26.51406 ?  131 ALA A N   1 
ATOM   815  C  CA  . ALA A 1 103 ? -46.13235 -57.27949 21.89713  1.000 20.79915 ?  131 ALA A CA  1 
ATOM   816  C  C   . ALA A 1 103 ? -46.92278 -57.54953 23.17034  1.000 29.91148 ?  131 ALA A C   1 
ATOM   817  O  O   . ALA A 1 103 ? -46.50084 -57.21150 24.27949  1.000 25.60899 ?  131 ALA A O   1 
ATOM   818  C  CB  . ALA A 1 103 ? -45.37003 -58.54026 21.48977  1.000 24.22303 ?  131 ALA A CB  1 
ATOM   819  N  N   . ARG A 1 104 ? -48.09157 -58.16067 22.99795  1.000 28.70135 ?  132 ARG A N   1 
ATOM   820  C  CA  . ARG A 1 104 ? -48.87324 -58.55575 24.15844  1.000 27.39577 ?  132 ARG A CA  1 
ATOM   821  C  C   . ARG A 1 104 ? -48.16114 -59.67780 24.90267  1.000 25.55550 ?  132 ARG A C   1 
ATOM   822  O  O   . ARG A 1 104 ? -47.40745 -60.46046 24.32023  1.000 27.35032 ?  132 ARG A O   1 
ATOM   823  C  CB  . ARG A 1 104 ? -50.27356 -59.00059 23.73197  1.000 25.11858 ?  132 ARG A CB  1 
ATOM   824  C  CG  . ARG A 1 104 ? -51.18734 -57.87775 23.33399  1.000 27.06582 ?  132 ARG A CG  1 
ATOM   825  C  CD  . ARG A 1 104 ? -52.55632 -58.40586 22.90560  1.000 30.82075 ?  132 ARG A CD  1 
ATOM   826  N  NE  . ARG A 1 104 ? -53.23478 -59.14311 23.97111  1.000 31.42722 ?  132 ARG A NE  1 
ATOM   827  C  CZ  . ARG A 1 104 ? -54.04881 -58.59986 24.86671  1.000 29.56633 ?  132 ARG A CZ  1 
ATOM   828  N  NH1 . ARG A 1 104 ? -54.27303 -57.29865 24.90216  1.000 28.06655 ?  132 ARG A NH1 1 
ATOM   829  N  NH2 . ARG A 1 104 ? -54.67535 -59.39031 25.74041  1.000 26.46879 ?  132 ARG A NH2 1 
ATOM   830  N  N   . ALA A 1 105 ? -48.40567 -59.74887 26.21691  1.000 29.10090 ?  133 ALA A N   1 
ATOM   831  C  CA  . ALA A 1 105 ? -47.80597 -60.81042 27.01651  1.000 30.60800 ?  133 ALA A CA  1 
ATOM   832  C  C   . ALA A 1 105 ? -48.23708 -62.18923 26.52964  1.000 38.14351 ?  133 ALA A C   1 
ATOM   833  O  O   . ALA A 1 105 ? -47.45118 -63.14065 26.58837  1.000 40.17561 ?  133 ALA A O   1 
ATOM   834  C  CB  . ALA A 1 105 ? -48.17971 -60.62926 28.48671  1.000 28.89031 ?  133 ALA A CB  1 
ATOM   835  N  N   . ASP A 1 106 ? -49.45923 -62.29811 26.00634  1.000 37.01353 ?  134 ASP A N   1 
ATOM   836  C  CA  . ASP A 1 106 ? -50.04289 -63.55327 25.54858  1.000 45.48053 ?  134 ASP A CA  1 
ATOM   837  C  C   . ASP A 1 106 ? -49.85776 -63.78821 24.04732  1.000 43.61850 ?  134 ASP A C   1 
ATOM   838  O  O   . ASP A 1 106 ? -50.55430 -64.63398 23.47583  1.000 39.63624 ?  134 ASP A O   1 
ATOM   839  C  CB  . ASP A 1 106 ? -51.53867 -63.60201 25.92395  1.000 43.92947 ?  134 ASP A CB  1 
ATOM   840  C  CG  . ASP A 1 106 ? -52.39660 -62.52068 25.21316  1.000 51.36072 ?  134 ASP A CG  1 
ATOM   841  O  OD1 . ASP A 1 106 ? -51.87210 -61.75018 24.38309  1.000 47.81437 ?  134 ASP A OD1 1 
ATOM   842  O  OD2 . ASP A 1 106 ? -53.62397 -62.44801 25.47722  1.000 40.40742 ?  134 ASP A OD2 1 
ATOM   843  N  N   . SER A 1 107 ? -48.93252 -63.07348 23.40067  1.000 29.90720 ?  135 SER A N   1 
ATOM   844  C  CA  . SER A 1 107 ? -48.87476 -63.04877 21.94078  1.000 30.15885 ?  135 SER A CA  1 
ATOM   845  C  C   . SER A 1 107 ? -48.06464 -64.18002 21.33305  1.000 30.47328 ?  135 SER A C   1 
ATOM   846  O  O   . SER A 1 107 ? -48.20663 -64.44876 20.12965  1.000 31.58856 ?  135 SER A O   1 
ATOM   847  C  CB  . SER A 1 107 ? -48.29207 -61.71166 21.46859  1.000 34.97277 ?  135 SER A CB  1 
ATOM   848  O  OG  . SER A 1 107 ? -46.92429 -61.63328 21.81678  1.000 30.49531 ?  135 SER A OG  1 
ATOM   849  N  N   . GLY A 1 108 ? -47.20934 -64.83825 22.11087  1.000 28.11074 ?  136 GLY A N   1 
ATOM   850  C  CA  . GLY A 1 108 ? -46.33174 -65.83132 21.53474  1.000 30.03518 ?  136 GLY A CA  1 
ATOM   851  C  C   . GLY A 1 108 ? -45.20295 -65.26666 20.70628  1.000 27.22980 ?  136 GLY A C   1 
ATOM   852  O  O   . GLY A 1 108 ? -44.47757 -66.03223 20.06552  1.000 34.00541 ?  136 GLY A O   1 
ATOM   853  N  N   . ILE A 1 109 ? -45.03196 -63.94841 20.71112  1.000 27.45592 ?  137 ILE A N   1 
ATOM   854  C  CA  . ILE A 1 109 ? -44.02437 -63.27002 19.90530  1.000 27.14660 ?  137 ILE A CA  1 
ATOM   855  C  C   . ILE A 1 109 ? -42.78859 -63.08922 20.77984  1.000 28.10498 ?  137 ILE A C   1 
ATOM   856  O  O   . ILE A 1 109 ? -42.83355 -62.37335 21.78223  1.000 30.23410 ?  137 ILE A O   1 
ATOM   857  C  CB  . ILE A 1 109 ? -44.55027 -61.93083 19.37897  1.000 28.97316 ?  137 ILE A CB  1 
ATOM   858  C  CG1 . ILE A 1 109 ? -45.72766 -62.17541 18.42814  1.000 32.53606 ?  137 ILE A CG1 1 
ATOM   859  C  CG2 . ILE A 1 109 ? -43.43824 -61.15893 18.66514  1.000 27.49349 ?  137 ILE A CG2 1 
ATOM   860  C  CD1 . ILE A 1 109 ? -46.51111 -60.92348 18.08491  1.000 26.47675 ?  137 ILE A CD1 1 
ATOM   861  N  N   . GLU A 1 110 ? -41.70493 -63.78431 20.43356  1.000 28.53250 ?  138 GLU A N   1 
ATOM   862  C  CA  . GLU A 1 110 ? -40.46110 -63.73627 21.20067  1.000 30.67440 ?  138 GLU A CA  1 
ATOM   863  C  C   . GLU A 1 110 ? -39.29069 -63.15663 20.42553  1.000 32.60314 ?  138 GLU A C   1 
ATOM   864  O  O   . GLU A 1 110 ? -38.25511 -62.85166 21.03274  1.000 28.83191 ?  138 GLU A O   1 
ATOM   865  C  CB  . GLU A 1 110 ? -40.08104 -65.14033 21.69047  1.000 33.63261 ?  138 GLU A CB  1 
ATOM   866  C  CG  . GLU A 1 110 ? -41.29001 -65.98107 22.03870  1.000 43.78828 ?  138 GLU A CG  1 
ATOM   867  C  CD  . GLU A 1 110 ? -40.98950 -67.06021 23.05208  1.000 59.69609 ?  138 GLU A CD  1 
ATOM   868  O  OE1 . GLU A 1 110 ? -39.91326 -67.69099 22.96034  1.000 62.15419 ?  138 GLU A OE1 1 
ATOM   869  O  OE2 . GLU A 1 110 ? -41.83324 -67.26609 23.95059  1.000 67.34843 ?  138 GLU A OE2 1 
ATOM   870  N  N   . ASN A 1 111 ? -39.42162 -62.99950 19.11372  1.000 28.92000 ?  139 ASN A N   1 
ATOM   871  C  CA  . ASN A 1 111 ? -38.39035 -62.39692 18.28497  1.000 25.50615 ?  139 ASN A CA  1 
ATOM   872  C  C   . ASN A 1 111 ? -39.07972 -61.91993 17.01890  1.000 27.02318 ?  139 ASN A C   1 
ATOM   873  O  O   . ASN A 1 111 ? -40.25882 -62.19393 16.80526  1.000 27.00585 ?  139 ASN A O   1 
ATOM   874  C  CB  . ASN A 1 111 ? -37.26980 -63.38142 17.95851  1.000 25.40194 ?  139 ASN A CB  1 
ATOM   875  C  CG  . ASN A 1 111 ? -35.92781 -62.69895 17.83319  1.000 33.08156 ?  139 ASN A CG  1 
ATOM   876  O  OD1 . ASN A 1 111 ? -35.76529 -61.75935 17.05187  1.000 28.43730 ?  139 ASN A OD1 1 
ATOM   877  N  ND2 . ASN A 1 111 ? -34.96111 -63.14758 18.62693  1.000 35.10726 ?  139 ASN A ND2 1 
ATOM   878  N  N   . VAL A 1 112 ? -38.32595 -61.21830 16.16960  1.000 25.69923 ?  140 VAL A N   1 
ATOM   879  C  CA  . VAL A 1 112 ? -38.94183 -60.59062 14.99516  1.000 21.69756 ?  140 VAL A CA  1 
ATOM   880  C  C   . VAL A 1 112 ? -39.54168 -61.63094 14.04654  1.000 28.18221 ?  140 VAL A C   1 
ATOM   881  O  O   . VAL A 1 112 ? -40.57370 -61.37387 13.41055  1.000 25.81642 ?  140 VAL A O   1 
ATOM   882  C  CB  . VAL A 1 112 ? -37.91887 -59.67544 14.27357  1.000 23.62993 ?  140 VAL A CB  1 
ATOM   883  C  CG1 . VAL A 1 112 ? -36.66589 -60.45040 13.81487  1.000 22.83147 ?  140 VAL A CG1 1 
ATOM   884  C  CG2 . VAL A 1 112 ? -38.58034 -58.94090 13.08667  1.000 23.34393 ?  140 VAL A CG2 1 
ATOM   885  N  N   . LYS A 1 113 ? -38.93697 -62.81900 13.94254  1.000 26.87098 ?  141 LYS A N   1 
ATOM   886  C  CA  A LYS A 1 113 ? -39.47439 -63.81860 13.02095  0.645 27.32058 ?  141 LYS A CA  1 
ATOM   887  C  CA  B LYS A 1 113 ? -39.46797 -63.83029 13.03041  0.355 27.35063 ?  141 LYS A CA  1 
ATOM   888  C  C   . LYS A 1 113 ? -40.87834 -64.26671 13.40470  1.000 28.03307 ?  141 LYS A C   1 
ATOM   889  O  O   . LYS A 1 113 ? -41.60502 -64.78309 12.54481  1.000 29.54663 ?  141 LYS A O   1 
ATOM   890  C  CB  A LYS A 1 113 ? -38.55480 -65.03899 12.94041  0.645 28.48529 ?  141 LYS A CB  1 
ATOM   891  C  CB  B LYS A 1 113 ? -38.55025 -65.05224 12.99291  0.355 28.54648 ?  141 LYS A CB  1 
ATOM   892  C  CG  A LYS A 1 113 ? -38.71466 -66.02047 14.09433  0.645 31.39125 ?  141 LYS A CG  1 
ATOM   893  C  CG  B LYS A 1 113 ? -38.56518 -65.86031 14.28013  0.355 31.09390 ?  141 LYS A CG  1 
ATOM   894  C  CD  A LYS A 1 113 ? -37.50818 -66.94678 14.20556  0.645 34.50563 ?  141 LYS A CD  1 
ATOM   895  C  CD  B LYS A 1 113 ? -38.03168 -67.26890 14.07185  0.355 34.47553 ?  141 LYS A CD  1 
ATOM   896  C  CE  A LYS A 1 113 ? -37.57632 -67.83959 15.45263  0.645 40.88878 ?  141 LYS A CE  1 
ATOM   897  C  CE  B LYS A 1 113 ? -38.06812 -68.06119 15.37324  0.355 39.29103 ?  141 LYS A CE  1 
ATOM   898  N  NZ  A LYS A 1 113 ? -38.95119 -68.33224 15.77574  0.645 36.09516 ?  141 LYS A NZ  1 
ATOM   899  N  NZ  B LYS A 1 113 ? -37.31823 -67.36817 16.45970  0.355 39.34117 ?  141 LYS A NZ  1 
ATOM   900  N  N   . ASP A 1 114 ? -41.28143 -64.08225 14.66420  1.000 26.44473 ?  142 ASP A N   1 
ATOM   901  C  CA  . ASP A 1 114 ? -42.60568 -64.49687 15.11400  1.000 27.58195 ?  142 ASP A CA  1 
ATOM   902  C  C   . ASP A 1 114 ? -43.70824 -63.52964 14.70344  1.000 27.67829 ?  142 ASP A C   1 
ATOM   903  O  O   . ASP A 1 114 ? -44.87523 -63.78369 15.01783  1.000 30.32652 ?  142 ASP A O   1 
ATOM   904  C  CB  . ASP A 1 114 ? -42.61445 -64.66724 16.63861  1.000 31.32683 ?  142 ASP A CB  1 
ATOM   905  C  CG  . ASP A 1 114 ? -41.67128 -65.77022 17.11376  1.000 32.08140 ?  142 ASP A CG  1 
ATOM   906  O  OD1 . ASP A 1 114 ? -41.40643 -66.72680 16.35164  1.000 32.09396 ?  142 ASP A OD1 1 
ATOM   907  O  OD2 . ASP A 1 114 ? -41.17393 -65.65963 18.25590  1.000 33.57545 ?  142 ASP A OD2 1 
ATOM   908  N  N   . LEU A 1 115 ? -43.38082 -62.43398 14.01081  1.000 24.11284 ?  143 LEU A N   1 
ATOM   909  C  CA  . LEU A 1 115 ? -44.41943 -61.49654 13.59764  1.000 24.61737 ?  143 LEU A CA  1 
ATOM   910  C  C   . LEU A 1 115 ? -45.29078 -62.08179 12.49207  1.000 25.30195 ?  143 LEU A C   1 
ATOM   911  O  O   . LEU A 1 115 ? -46.46391 -61.70792 12.36309  1.000 26.56705 ?  143 LEU A O   1 
ATOM   912  C  CB  . LEU A 1 115 ? -43.78398 -60.18343 13.13131  1.000 24.89154 ?  143 LEU A CB  1 
ATOM   913  C  CG  . LEU A 1 115 ? -43.15623 -59.31678 14.23424  1.000 24.49568 ?  143 LEU A CG  1 
ATOM   914  C  CD1 . LEU A 1 115 ? -42.44923 -58.12381 13.60271  1.000 26.15416 ?  143 LEU A CD1 1 
ATOM   915  C  CD2 . LEU A 1 115 ? -44.17650 -58.84312 15.25649  1.000 26.39509 ?  143 LEU A CD2 1 
ATOM   916  N  N   . ALA A 1 116 ? -44.73266 -62.95990 11.66870  1.000 28.42293 ?  144 ALA A N   1 
ATOM   917  C  CA  . ALA A 1 116 ? -45.52742 -63.56623 10.60771  1.000 31.51226 ?  144 ALA A CA  1 
ATOM   918  C  C   . ALA A 1 116 ? -46.65253 -64.39076 11.21732  1.000 30.70793 ?  144 ALA A C   1 
ATOM   919  O  O   . ALA A 1 116 ? -46.45536 -65.10336 12.20666  1.000 29.47729 ?  144 ALA A O   1 
ATOM   920  C  CB  . ALA A 1 116 ? -44.64919 -64.43329 9.70908   1.000 32.06281 ?  144 ALA A CB  1 
ATOM   921  N  N   . GLY A 1 117 ? -47.85181 -64.25646 10.64951  1.000 30.79652 ?  145 GLY A N   1 
ATOM   922  C  CA  . GLY A 1 117 ? -49.00370 -64.97890 11.16217  1.000 29.40901 ?  145 GLY A CA  1 
ATOM   923  C  C   . GLY A 1 117 ? -49.65578 -64.37758 12.38020  1.000 34.93882 ?  145 GLY A C   1 
ATOM   924  O  O   . GLY A 1 117 ? -50.44061 -65.05546 13.05048  1.000 33.32533 ?  145 GLY A O   1 
ATOM   925  N  N   . LYS A 1 118 ? -49.35980 -63.12533 12.69589  1.000 26.25661 ?  146 LYS A N   1 
ATOM   926  C  CA  . LYS A 1 118 ? -49.95895 -62.42876 13.81727  1.000 28.53614 ?  146 LYS A CA  1 
ATOM   927  C  C   . LYS A 1 118 ? -50.61954 -61.15519 13.30876  1.000 24.49787 ?  146 LYS A C   1 
ATOM   928  O  O   . LYS A 1 118 ? -50.48907 -60.78544 12.13394  1.000 28.88139 ?  146 LYS A O   1 
ATOM   929  C  CB  . LYS A 1 118 ? -48.90432 -62.10848 14.88691  1.000 25.64638 ?  146 LYS A CB  1 
ATOM   930  C  CG  . LYS A 1 118 ? -48.22371 -63.34289 15.46966  1.000 25.54988 ?  146 LYS A CG  1 
ATOM   931  C  CD  . LYS A 1 118 ? -49.16448 -64.10140 16.39885  1.000 31.16540 ?  146 LYS A CD  1 
ATOM   932  C  CE  . LYS A 1 118 ? -48.54444 -65.41411 16.84549  1.000 31.82433 ?  146 LYS A CE  1 
ATOM   933  N  NZ  . LYS A 1 118 ? -49.47827 -66.14117 17.74986  1.000 35.06317 ?  146 LYS A NZ  1 
ATOM   934  N  N   . ARG A 1 119 ? -51.35957 -60.50914 14.19678  1.000 24.80908 ?  147 ARG A N   1 
ATOM   935  C  CA  . ARG A 1 119 ? -51.94287 -59.19803 13.93519  1.000 20.73004 ?  147 ARG A CA  1 
ATOM   936  C  C   . ARG A 1 119 ? -50.89564 -58.15835 14.31830  1.000 26.28656 ?  147 ARG A C   1 
ATOM   937  O  O   . ARG A 1 119 ? -50.60696 -57.96748 15.50540  1.000 27.64023 ?  147 ARG A O   1 
ATOM   938  C  CB  . ARG A 1 119 ? -53.22927 -59.00373 14.73310  1.000 26.50833 ?  147 ARG A CB  1 
ATOM   939  C  CG  . ARG A 1 119 ? -54.24234 -60.13382 14.58471  1.000 27.02037 ?  147 ARG A CG  1 
ATOM   940  C  CD  . ARG A 1 119 ? -55.38060 -59.97293 15.59092  1.000 28.48798 ?  147 ARG A CD  1 
ATOM   941  N  NE  . ARG A 1 119 ? -54.95202 -60.20022 16.97568  1.000 29.94126 ?  147 ARG A NE  1 
ATOM   942  C  CZ  . ARG A 1 119 ? -55.58396 -59.73748 18.05095  1.000 25.04188 ?  147 ARG A CZ  1 
ATOM   943  N  NH1 . ARG A 1 119 ? -56.71469 -59.05064 17.95666  1.000 26.60842 ?  147 ARG A NH1 1 
ATOM   944  N  NH2 . ARG A 1 119 ? -55.06563 -59.96201 19.25664  1.000 34.69031 ?  147 ARG A NH2 1 
ATOM   945  N  N   . VAL A 1 120 ? -50.33098 -57.48236 13.32296  1.000 24.20706 ?  148 VAL A N   1 
ATOM   946  C  CA  . VAL A 1 120 ? -49.17356 -56.61751 13.53548  1.000 22.33397 ?  148 VAL A CA  1 
ATOM   947  C  C   . VAL A 1 120 ? -49.49047 -55.22973 13.00011  1.000 26.56068 ?  148 VAL A C   1 
ATOM   948  O  O   . VAL A 1 120 ? -49.86640 -55.08628 11.83329  1.000 25.35461 ?  148 VAL A O   1 
ATOM   949  C  CB  . VAL A 1 120 ? -47.91349 -57.16554 12.84508  1.000 25.48099 ?  148 VAL A CB  1 
ATOM   950  C  CG1 . VAL A 1 120 ? -46.72420 -56.23613 13.11002  1.000 26.06320 ?  148 VAL A CG1 1 
ATOM   951  C  CG2 . VAL A 1 120 ? -47.61706 -58.60043 13.28241  1.000 26.68220 ?  148 VAL A CG2 1 
ATOM   952  N  N   . ASN A 1 121 ? -49.32067 -54.20175 13.83105  1.000 22.02792 ?  149 ASN A N   1 
ATOM   953  C  CA  . ASN A 1 121 ? -49.38140 -52.84398 13.29347  1.000 22.64161 ?  149 ASN A CA  1 
ATOM   954  C  C   . ASN A 1 121 ? -48.05148 -52.54370 12.62240  1.000 26.05686 ?  149 ASN A C   1 
ATOM   955  O  O   . ASN A 1 121 ? -47.03885 -52.34151 13.30364  1.000 22.23423 ?  149 ASN A O   1 
ATOM   956  C  CB  . ASN A 1 121 ? -49.67823 -51.80797 14.37045  1.000 20.89691 ?  149 ASN A CB  1 
ATOM   957  C  CG  . ASN A 1 121 ? -50.26262 -50.53658 13.79182  1.000 24.29090 ?  149 ASN A CG  1 
ATOM   958  O  OD1 . ASN A 1 121 ? -51.46563 -50.45774 13.51607  1.000 23.35511 ?  149 ASN A OD1 1 
ATOM   959  N  ND2 . ASN A 1 121 ? -49.41333 -49.53739 13.57718  1.000 21.02160 ?  149 ASN A ND2 1 
ATOM   960  N  N   . ILE A 1 122 ? -48.04494 -52.53348 11.28341  1.000 21.44186 ?  150 ILE A N   1 
ATOM   961  C  CA  . ILE A 1 122 ? -46.81197 -52.27432 10.55405  1.000 20.43253 ?  150 ILE A CA  1 
ATOM   962  C  C   . ILE A 1 122 ? -46.52892 -50.79495 10.40822  1.000 21.78043 ?  150 ILE A C   1 
ATOM   963  O  O   . ILE A 1 122 ? -45.42099 -50.44027 10.00502  1.000 23.65663 ?  150 ILE A O   1 
ATOM   964  C  CB  . ILE A 1 122 ? -46.85398 -52.93972 9.16559   1.000 21.74720 ?  150 ILE A CB  1 
ATOM   965  C  CG1 . ILE A 1 122 ? -48.08028 -52.45127 8.39016   1.000 25.61784 ?  150 ILE A CG1 1 
ATOM   966  C  CG2 . ILE A 1 122 ? -46.85597 -54.45717 9.31600   1.000 26.89129 ?  150 ILE A CG2 1 
ATOM   967  C  CD1 . ILE A 1 122 ? -48.04082 -52.82604 6.89023   1.000 32.00256 ?  150 ILE A CD1 1 
ATOM   968  N  N   . GLY A 1 123 ? -47.49914 -49.92964 10.71031  1.000 21.95556 ?  151 GLY A N   1 
ATOM   969  C  CA  . GLY A 1 123 ? -47.29543 -48.49375 10.66055  1.000 20.58807 ?  151 GLY A CA  1 
ATOM   970  C  C   . GLY A 1 123 ? -48.15534 -47.77555 9.63743   1.000 19.82786 ?  151 GLY A C   1 
ATOM   971  O  O   . GLY A 1 123 ? -48.59498 -48.37500 8.65237   1.000 22.69325 ?  151 GLY A O   1 
ATOM   972  N  N   . ASN A 1 124 ? -48.37891 -46.48193 9.85182   1.000 21.18335 ?  152 ASN A N   1 
ATOM   973  C  CA  . ASN A 1 124 ? -49.18282 -45.64501 8.97877   1.000 22.47710 ?  152 ASN A CA  1 
ATOM   974  C  C   . ASN A 1 124 ? -48.36742 -45.21280 7.75385   1.000 20.99881 ?  152 ASN A C   1 
ATOM   975  O  O   . ASN A 1 124 ? -47.13544 -45.13796 7.81386   1.000 20.14779 ?  152 ASN A O   1 
ATOM   976  C  CB  . ASN A 1 124 ? -49.68463 -44.41288 9.72893   1.000 23.13961 ?  152 ASN A CB  1 
ATOM   977  C  CG  . ASN A 1 124 ? -48.56135 -43.61227 10.36379  1.000 20.82949 ?  152 ASN A CG  1 
ATOM   978  O  OD1 . ASN A 1 124 ? -47.93023 -44.05898 11.33544  1.000 19.77033 ?  152 ASN A OD1 1 
ATOM   979  N  ND2 . ASN A 1 124 ? -48.30189 -42.42723 9.82576   1.000 21.94450 ?  152 ASN A ND2 1 
ATOM   980  N  N   . PRO A 1 125 ? -49.03791 -44.92314 6.63735   1.000 23.92735 ?  153 PRO A N   1 
ATOM   981  C  CA  . PRO A 1 125 ? -48.31396 -44.67837 5.37234   1.000 21.29307 ?  153 PRO A CA  1 
ATOM   982  C  C   . PRO A 1 125 ? -47.29953 -43.54286 5.39749   1.000 25.99346 ?  153 PRO A C   1 
ATOM   983  O  O   . PRO A 1 125 ? -46.29946 -43.61420 4.66444   1.000 34.52835 ?  153 PRO A O   1 
ATOM   984  C  CB  . PRO A 1 125 ? -49.44222 -44.38014 4.37747   1.000 28.61232 ?  153 PRO A CB  1 
ATOM   985  C  CG  . PRO A 1 125 ? -50.67088 -44.92251 4.97322   1.000 31.87330 ?  153 PRO A CG  1 
ATOM   986  C  CD  . PRO A 1 125 ? -50.49300 -45.04717 6.44635   1.000 28.71926 ?  153 PRO A CD  1 
ATOM   987  N  N   . GLY A 1 126 ? -47.51885 -42.49544 6.17095   1.000 27.83068 ?  154 GLY A N   1 
ATOM   988  C  CA  . GLY A 1 126 ? -46.47023 -41.48997 6.17269   1.000 26.75075 ?  154 GLY A CA  1 
ATOM   989  C  C   . GLY A 1 126 ? -45.28931 -41.75427 7.09090   1.000 21.64343 ?  154 GLY A C   1 
ATOM   990  O  O   . GLY A 1 126 ? -44.40040 -40.90799 7.18488   1.000 20.03576 ?  154 GLY A O   1 
ATOM   991  N  N   . SER A 1 127 ? -45.24095 -42.88869 7.77661   1.000 20.68112 ?  155 SER A N   1 
ATOM   992  C  CA  . SER A 1 127 ? -44.26516 -43.06925 8.84353   1.000 18.83777 ?  155 SER A CA  1 
ATOM   993  C  C   . SER A 1 127 ? -42.97493 -43.72740 8.36942   1.000 20.80455 ?  155 SER A C   1 
ATOM   994  O  O   . SER A 1 127 ? -42.96887 -44.57975 7.47005   1.000 20.73571 ?  155 SER A O   1 
ATOM   995  C  CB  . SER A 1 127 ? -44.85703 -43.91039 9.98193   1.000 20.01903 ?  155 SER A CB  1 
ATOM   996  O  OG  . SER A 1 127 ? -45.13519 -45.24356 9.55956   1.000 20.78230 ?  155 SER A OG  1 
ATOM   997  N  N   . GLY A 1 128 ? -41.87096 -43.33771 9.02454   1.000 20.04057 ?  156 GLY A N   1 
ATOM   998  C  CA  . GLY A 1 128 ? -40.65502 -44.12693 8.93669   1.000 19.71596 ?  156 GLY A CA  1 
ATOM   999  C  C   . GLY A 1 128 ? -40.84491 -45.52799 9.47394   1.000 20.50683 ?  156 GLY A C   1 
ATOM   1000 O  O   . GLY A 1 128 ? -40.15358 -46.46116 9.05144   1.000 19.63146 ?  156 GLY A O   1 
ATOM   1001 N  N   . ASP A 1 129 ? -41.78692 -45.69857 10.41272  1.000 19.92603 ?  157 ASP A N   1 
ATOM   1002 C  CA  . ASP A 1 129 ? -42.10341 -47.02265 10.92646  1.000 19.97299 ?  157 ASP A CA  1 
ATOM   1003 C  C   . ASP A 1 129 ? -42.42834 -47.98256 9.79406   1.000 19.53321 ?  157 ASP A C   1 
ATOM   1004 O  O   . ASP A 1 129 ? -41.83019 -49.05073 9.66551   1.000 20.36272 ?  157 ASP A O   1 
ATOM   1005 C  CB  . ASP A 1 129 ? -43.30548 -46.95790 11.88102  1.000 19.53152 ?  157 ASP A CB  1 
ATOM   1006 C  CG  . ASP A 1 129 ? -43.12353 -45.94252 13.01362  1.000 23.95884 ?  157 ASP A CG  1 
ATOM   1007 O  OD1 . ASP A 1 129 ? -41.99195 -45.76740 13.50638  1.000 20.64951 ?  157 ASP A OD1 1 
ATOM   1008 O  OD2 . ASP A 1 129 ? -44.13984 -45.35218 13.44098  1.000 21.01300 ?  157 ASP A OD2 1 
ATOM   1009 N  N   . ARG A 1 130 ? -43.41579 -47.61455 8.97999   1.000 18.86789 ?  158 ARG A N   1 
ATOM   1010 C  CA  . ARG A 1 130 ? -43.88885 -48.52356 7.94796   1.000 20.76710 ?  158 ARG A CA  1 
ATOM   1011 C  C   . ARG A 1 130 ? -42.82346 -48.72267 6.88252   1.000 21.34619 ?  158 ARG A C   1 
ATOM   1012 O  O   . ARG A 1 130 ? -42.61787 -49.84343 6.39763   1.000 22.33630 ?  158 ARG A O   1 
ATOM   1013 C  CB  . ARG A 1 130 ? -45.17521 -47.97989 7.33912   1.000 19.16408 ?  158 ARG A CB  1 
ATOM   1014 C  CG  . ARG A 1 130 ? -45.89743 -49.01580 6.48213   1.000 27.11893 ?  158 ARG A CG  1 
ATOM   1015 C  CD  . ARG A 1 130 ? -46.98667 -48.37498 5.64126   1.000 35.06718 ?  158 ARG A CD  1 
ATOM   1016 N  NE  . ARG A 1 130 ? -47.95047 -49.37602 5.19280   1.000 40.26424 ?  158 ARG A NE  1 
ATOM   1017 C  CZ  . ARG A 1 130 ? -47.81708 -50.05727 4.06298   1.000 49.16602 ?  158 ARG A CZ  1 
ATOM   1018 N  NH1 . ARG A 1 130 ? -46.75445 -49.89981 3.28861   1.000 44.73793 ?  158 ARG A NH1 1 
ATOM   1019 N  NH2 . ARG A 1 130 ? -48.76372 -50.92490 3.70729   1.000 37.08861 ?  158 ARG A NH2 1 
ATOM   1020 N  N   . ALA A 1 131 ? -42.10408 -47.65092 6.53857   1.000 19.82453 ?  159 ALA A N   1 
ATOM   1021 C  CA  . ALA A 1 131 ? -41.10986 -47.75856 5.47436   1.000 20.48159 ?  159 ALA A CA  1 
ATOM   1022 C  C   . ALA A 1 131 ? -39.94968 -48.65938 5.88960   1.000 21.58226 ?  159 ALA A C   1 
ATOM   1023 O  O   . ALA A 1 131 ? -39.48692 -49.48974 5.09752   1.000 22.20927 ?  159 ALA A O   1 
ATOM   1024 C  CB  . ALA A 1 131 ? -40.63707 -46.35906 5.08129   1.000 17.70025 ?  159 ALA A CB  1 
ATOM   1025 N  N   . THR A 1 132 ? -39.47637 -48.53559 7.13570   1.000 18.83161 ?  160 THR A N   1 
ATOM   1026 C  CA  . THR A 1 132 ? -38.40364 -49.41919 7.57547   1.000 18.57581 ?  160 THR A CA  1 
ATOM   1027 C  C   . THR A 1 132 ? -38.93060 -50.82672 7.83923   1.000 18.50547 ?  160 THR A C   1 
ATOM   1028 O  O   . THR A 1 132 ? -38.20403 -51.79916 7.62948   1.000 22.30840 ?  160 THR A O   1 
ATOM   1029 C  CB  . THR A 1 132 ? -37.70899 -48.84463 8.81998   1.000 19.28145 ?  160 THR A CB  1 
ATOM   1030 O  OG1 . THR A 1 132 ? -37.23011 -47.51473 8.54815   1.000 19.50423 ?  160 THR A OG1 1 
ATOM   1031 C  CG2 . THR A 1 132 ? -36.52630 -49.72290 9.23913   1.000 20.08766 ?  160 THR A CG2 1 
ATOM   1032 N  N   . MET A 1 133 ? -40.18899 -50.95656 8.28294   1.000 19.34778 ?  161 MET A N   1 
ATOM   1033 C  CA  . MET A 1 133 ? -40.81355 -52.27554 8.36504   1.000 20.71090 ?  161 MET A CA  1 
ATOM   1034 C  C   . MET A 1 133 ? -40.78469 -52.99553 7.02605   1.000 18.90524 ?  161 MET A C   1 
ATOM   1035 O  O   . MET A 1 133 ? -40.58926 -54.21403 6.98745   1.000 20.84047 ?  161 MET A O   1 
ATOM   1036 C  CB  . MET A 1 133 ? -42.26660 -52.17310 8.83653   1.000 19.54508 ?  161 MET A CB  1 
ATOM   1037 C  CG  . MET A 1 133 ? -42.92750 -53.45746 9.34938   1.000 24.28756 ?  161 MET A CG  1 
ATOM   1038 S  SD  . MET A 1 133 ? -41.94603 -54.68468 10.22028  1.000 24.08326 ?  161 MET A SD  1 
ATOM   1039 C  CE  . MET A 1 133 ? -43.11310 -56.03617 10.33356  1.000 26.93259 ?  161 MET A CE  1 
ATOM   1040 N  N   . GLN A 1 134 ? -40.95647 -52.26361 5.92070   1.000 24.49386 ?  162 GLN A N   1 
ATOM   1041 C  CA  . GLN A 1 134 ? -40.87445 -52.88957 4.59991   1.000 24.64289 ?  162 GLN A CA  1 
ATOM   1042 C  C   . GLN A 1 134 ? -39.50128 -53.50763 4.35838   1.000 25.99943 ?  162 GLN A C   1 
ATOM   1043 O  O   . GLN A 1 134 ? -39.38731 -54.56970 3.72881   1.000 24.81613 ?  162 GLN A O   1 
ATOM   1044 C  CB  . GLN A 1 134 ? -41.19272 -51.86005 3.50984   1.000 24.31061 ?  162 GLN A CB  1 
ATOM   1045 C  CG  . GLN A 1 134 ? -41.16375 -52.43961 2.08448   1.000 33.14877 ?  162 GLN A CG  1 
ATOM   1046 C  CD  . GLN A 1 134 ? -42.16581 -53.56068 1.91731   1.000 38.73422 ?  162 GLN A CD  1 
ATOM   1047 O  OE1 . GLN A 1 134 ? -43.34644 -53.40004 2.25323   1.000 39.48787 ?  162 GLN A OE1 1 
ATOM   1048 N  NE2 . GLN A 1 134 ? -41.70296 -54.71246 1.41366   1.000 31.66781 ?  162 GLN A NE2 1 
ATOM   1049 N  N   . VAL A 1 135 ? -38.44473 -52.84709 4.83983   1.000 22.39897 ?  163 VAL A N   1 
ATOM   1050 C  CA  . VAL A 1 135 ? -37.08935 -53.37313 4.72342   1.000 22.22292 ?  163 VAL A CA  1 
ATOM   1051 C  C   . VAL A 1 135 ? -36.96245 -54.69105 5.47734   1.000 22.40646 ?  163 VAL A C   1 
ATOM   1052 O  O   . VAL A 1 135 ? -36.35532 -55.65634 4.99211   1.000 25.37048 ?  163 VAL A O   1 
ATOM   1053 C  CB  . VAL A 1 135 ? -36.08053 -52.33183 5.23948   1.000 25.99432 ?  163 VAL A CB  1 
ATOM   1054 C  CG1 . VAL A 1 135 ? -34.68300 -52.89949 5.25089   1.000 26.48531 ?  163 VAL A CG1 1 
ATOM   1055 C  CG2 . VAL A 1 135 ? -36.15677 -51.05266 4.42423   1.000 24.10209 ?  163 VAL A CG2 1 
ATOM   1056 N  N   . VAL A 1 136 ? -37.49784 -54.73399 6.69846   1.000 22.32511 ?  164 VAL A N   1 
ATOM   1057 C  CA  . VAL A 1 136 ? -37.50830 -55.97506 7.46715   1.000 22.19469 ?  164 VAL A CA  1 
ATOM   1058 C  C   . VAL A 1 136 ? -38.32069 -57.02758 6.73264   1.000 26.08668 ?  164 VAL A C   1 
ATOM   1059 O  O   . VAL A 1 136 ? -37.92262 -58.19561 6.62200   1.000 26.49083 ?  164 VAL A O   1 
ATOM   1060 C  CB  . VAL A 1 136 ? -38.06667 -55.71076 8.87663   1.000 22.59971 ?  164 VAL A CB  1 
ATOM   1061 C  CG1 . VAL A 1 136 ? -38.26987 -57.02264 9.62731   1.000 23.58077 ?  164 VAL A CG1 1 
ATOM   1062 C  CG2 . VAL A 1 136 ? -37.15256 -54.74775 9.64241   1.000 24.75264 ?  164 VAL A CG2 1 
ATOM   1063 N  N   . MET A 1 137 ? -39.45995 -56.61012 6.19440   1.000 25.56549 ?  165 MET A N   1 
ATOM   1064 C  CA  . MET A 1 137 ? -40.31650 -57.51093 5.44426   1.000 27.60274 ?  165 MET A CA  1 
ATOM   1065 C  C   . MET A 1 137 ? -39.55880 -58.07673 4.24426   1.000 27.39120 ?  165 MET A C   1 
ATOM   1066 O  O   . MET A 1 137 ? -39.58655 -59.29026 3.99987   1.000 31.55923 ?  165 MET A O   1 
ATOM   1067 C  CB  . MET A 1 137 ? -41.55045 -56.71852 5.02343   1.000 26.29433 ?  165 MET A CB  1 
ATOM   1068 C  CG  . MET A 1 137 ? -42.73334 -56.88610 5.97099   1.000 29.47552 ?  165 MET A CG  1 
ATOM   1069 S  SD  . MET A 1 137 ? -43.89784 -55.50088 5.78417   1.000 27.92173 ?  165 MET A SD  1 
ATOM   1070 C  CE  . MET A 1 137 ? -44.96113 -56.27378 4.54920   1.000 29.82378 ?  165 MET A CE  1 
ATOM   1071 N  N   . ASP A 1 138 ? -38.82972 -57.21737 3.51742   1.000 28.24050 ?  166 ASP A N   1 
ATOM   1072 C  CA  . ASP A 1 138 ? -38.00352 -57.67285 2.39241   1.000 25.80352 ?  166 ASP A CA  1 
ATOM   1073 C  C   . ASP A 1 138 ? -37.02401 -58.75478 2.82832   1.000 33.98901 ?  166 ASP A C   1 
ATOM   1074 O  O   . ASP A 1 138 ? -36.85001 -59.76692 2.13879   1.000 29.67241 ?  166 ASP A O   1 
ATOM   1075 C  CB  . ASP A 1 138 ? -37.21169 -56.50932 1.78154   1.000 31.19298 ?  166 ASP A CB  1 
ATOM   1076 C  CG  . ASP A 1 138 ? -38.05112 -55.59597 0.91838   1.000 38.04086 ?  166 ASP A CG  1 
ATOM   1077 O  OD1 . ASP A 1 138 ? -39.22839 -55.92017 0.65025   1.000 38.69505 ?  166 ASP A OD1 1 
ATOM   1078 O  OD2 . ASP A 1 138 ? -37.51760 -54.53242 0.52339   1.000 38.14859 ?  166 ASP A OD2 1 
ATOM   1079 N  N   . ALA A 1 139 ? -36.33206 -58.52568 3.94907   1.000 28.37036 ?  167 ALA A N   1 
ATOM   1080 C  CA  . ALA A 1 139 ? -35.32014 -59.46668 4.41278   1.000 25.58524 ?  167 ALA A CA  1 
ATOM   1081 C  C   . ALA A 1 139 ? -35.91259 -60.83922 4.69618   1.000 28.02493 ?  167 ALA A C   1 
ATOM   1082 O  O   . ALA A 1 139 ? -35.22267 -61.85457 4.53692   1.000 31.28913 ?  167 ALA A O   1 
ATOM   1083 C  CB  . ALA A 1 139 ? -34.63152 -58.91912 5.66408   1.000 25.82110 ?  167 ALA A CB  1 
ATOM   1084 N  N   . PHE A 1 140 ? -37.18154 -60.89356 5.09449   1.000 26.84836 ?  168 PHE A N   1 
ATOM   1085 C  CA  . PHE A 1 140 ? -37.85100 -62.14875 5.41111   1.000 28.75140 ?  168 PHE A CA  1 
ATOM   1086 C  C   . PHE A 1 140 ? -38.63322 -62.71670 4.23618   1.000 29.40511 ?  168 PHE A C   1 
ATOM   1087 O  O   . PHE A 1 140 ? -39.17598 -63.81961 4.35510   1.000 32.80628 ?  168 PHE A O   1 
ATOM   1088 C  CB  . PHE A 1 140 ? -38.81657 -61.96689 6.58776   1.000 28.73354 ?  168 PHE A CB  1 
ATOM   1089 C  CG  . PHE A 1 140 ? -38.17076 -62.10663 7.93857   1.000 27.67840 ?  168 PHE A CG  1 
ATOM   1090 C  CD1 . PHE A 1 140 ? -38.04672 -63.35255 8.53528   1.000 28.99943 ?  168 PHE A CD1 1 
ATOM   1091 C  CD2 . PHE A 1 140 ? -37.69015 -60.99336 8.61522   1.000 30.06461 ?  168 PHE A CD2 1 
ATOM   1092 C  CE1 . PHE A 1 140 ? -37.45606 -63.49418 9.78248   1.000 27.24482 ?  168 PHE A CE1 1 
ATOM   1093 C  CE2 . PHE A 1 140 ? -37.10016 -61.12460 9.86958   1.000 25.38656 ?  168 PHE A CE2 1 
ATOM   1094 C  CZ  . PHE A 1 140 ? -36.97722 -62.37558 10.45474  1.000 23.32390 ?  168 PHE A CZ  1 
ATOM   1095 N  N   . GLY A 1 141 ? -38.72157 -61.99449 3.12122   1.000 30.51685 ?  169 GLY A N   1 
ATOM   1096 C  CA  . GLY A 1 141 ? -39.61334 -62.41249 2.05396   1.000 30.27581 ?  169 GLY A CA  1 
ATOM   1097 C  C   . GLY A 1 141 ? -41.07686 -62.24752 2.37956   1.000 35.59245 ?  169 GLY A C   1 
ATOM   1098 O  O   . GLY A 1 141 ? -41.91779 -62.93034 1.79359   1.000 35.01908 ?  169 GLY A O   1 
ATOM   1099 N  N   . TRP A 1 142 ? -41.40543 -61.36151 3.30903   1.000 24.98105 ?  170 TRP A N   1 
ATOM   1100 C  CA  . TRP A 1 142 ? -42.77433 -61.12903 3.72845   1.000 26.43066 ?  170 TRP A CA  1 
ATOM   1101 C  C   . TRP A 1 142 ? -43.43587 -60.09435 2.83166   1.000 28.10964 ?  170 TRP A C   1 
ATOM   1102 O  O   . TRP A 1 142 ? -42.78475 -59.19880 2.28496   1.000 32.61152 ?  170 TRP A O   1 
ATOM   1103 C  CB  . TRP A 1 142 ? -42.82859 -60.62600 5.17118   1.000 25.74776 ?  170 TRP A CB  1 
ATOM   1104 C  CG  . TRP A 1 142 ? -42.45646 -61.62272 6.22100   1.000 28.88651 ?  170 TRP A CG  1 
ATOM   1105 C  CD1 . TRP A 1 142 ? -42.38661 -62.98409 6.09262   1.000 32.37156 ?  170 TRP A CD1 1 
ATOM   1106 C  CD2 . TRP A 1 142 ? -42.07133 -61.32423 7.57241   1.000 26.08832 ?  170 TRP A CD2 1 
ATOM   1107 N  NE1 . TRP A 1 142 ? -41.99055 -63.55255 7.29685   1.000 30.38962 ?  170 TRP A NE1 1 
ATOM   1108 C  CE2 . TRP A 1 142 ? -41.78199 -62.54996 8.21038   1.000 26.58061 ?  170 TRP A CE2 1 
ATOM   1109 C  CE3 . TRP A 1 142 ? -41.92663 -60.13875 8.29545   1.000 28.37376 ?  170 TRP A CE3 1 
ATOM   1110 C  CZ2 . TRP A 1 142 ? -41.38116 -62.62082 9.54171   1.000 29.44986 ?  170 TRP A CZ2 1 
ATOM   1111 C  CZ3 . TRP A 1 142 ? -41.52446 -60.21566 9.62136   1.000 28.24334 ?  170 TRP A CZ3 1 
ATOM   1112 C  CH2 . TRP A 1 142 ? -41.25701 -61.44639 10.22528  1.000 27.23777 ?  170 TRP A CH2 1 
ATOM   1113 N  N   . ASN A 1 143 ? -44.74868 -60.20914 2.71429   1.000 25.63114 ?  171 ASN A N   1 
ATOM   1114 C  CA  . ASN A 1 143 ? -45.58239 -59.14774 2.18354   1.000 27.23291 ?  171 ASN A CA  1 
ATOM   1115 C  C   . ASN A 1 143 ? -46.71622 -58.89436 3.17365   1.000 26.58851 ?  171 ASN A C   1 
ATOM   1116 O  O   . ASN A 1 143 ? -46.73660 -59.46212 4.27344   1.000 28.91107 ?  171 ASN A O   1 
ATOM   1117 C  CB  . ASN A 1 143 ? -46.03289 -59.48977 0.75228   1.000 31.52182 ?  171 ASN A CB  1 
ATOM   1118 C  CG  . ASN A 1 143 ? -46.87513 -60.73095 0.68424   1.000 36.93410 ?  171 ASN A CG  1 
ATOM   1119 O  OD1 . ASN A 1 143 ? -47.56808 -61.09001 1.63325   1.000 41.46474 ?  171 ASN A OD1 1 
ATOM   1120 N  ND2 . ASN A 1 143 ? -46.79111 -61.42718 -0.44726  1.000 47.87776 ?  171 ASN A ND2 1 
ATOM   1121 N  N   . ASN A 1 144 ? -47.63021 -57.98081 2.83070   1.000 27.28125 ?  172 ASN A N   1 
ATOM   1122 C  CA  . ASN A 1 144 ? -48.68258 -57.63940 3.79028   1.000 31.03751 ?  172 ASN A CA  1 
ATOM   1123 C  C   . ASN A 1 144 ? -49.51780 -58.85403 4.16970   1.000 30.98716 ?  172 ASN A C   1 
ATOM   1124 O  O   . ASN A 1 144 ? -50.01624 -58.93175 5.30082   1.000 30.71825 ?  172 ASN A O   1 
ATOM   1125 C  CB  . ASN A 1 144 ? -49.58742 -56.53042 3.24480   1.000 32.42133 ?  172 ASN A CB  1 
ATOM   1126 C  CG  . ASN A 1 144 ? -49.00945 -55.14540 3.46236   1.000 40.87387 ?  172 ASN A CG  1 
ATOM   1127 O  OD1 . ASN A 1 144 ? -47.82575 -54.99386 3.76239   1.000 37.68147 ?  172 ASN A OD1 1 
ATOM   1128 N  ND2 . ASN A 1 144 ? -49.84257 -54.12765 3.31126   1.000 43.62819 ?  172 ASN A ND2 1 
ATOM   1129 N  N   . ASP A 1 145 ? -49.66984 -59.81340 3.24916   1.000 26.11331 ?  173 ASP A N   1 
ATOM   1130 C  CA  . ASP A 1 145 ? -50.42805 -61.03712 3.51070   1.000 33.35609 ?  173 ASP A CA  1 
ATOM   1131 C  C   . ASP A 1 145 ? -49.69800 -62.01935 4.41331   1.000 32.87447 ?  173 ASP A C   1 
ATOM   1132 O  O   . ASP A 1 145 ? -50.29194 -63.03894 4.78261   1.000 30.13337 ?  173 ASP A O   1 
ATOM   1133 C  CB  . ASP A 1 145 ? -50.76798 -61.76517 2.20154   1.000 34.78479 ?  173 ASP A CB  1 
ATOM   1134 C  CG  . ASP A 1 145 ? -51.75625 -61.00760 1.35173   1.000 54.28020 ?  173 ASP A CG  1 
ATOM   1135 O  OD1 . ASP A 1 145 ? -52.59462 -60.28054 1.92375   1.000 59.07997 ?  173 ASP A OD1 1 
ATOM   1136 O  OD2 . ASP A 1 145 ? -51.70007 -61.14964 0.11058   1.000 63.87655 ?  173 ASP A OD2 1 
ATOM   1137 N  N   . SER A 1 146 ? -48.43050 -61.76029 4.75411   1.000 27.50573 ?  174 SER A N   1 
ATOM   1138 C  CA  . SER A 1 146 ? -47.72807 -62.62532 5.69160   1.000 27.14030 ?  174 SER A CA  1 
ATOM   1139 C  C   . SER A 1 146 ? -48.27539 -62.48236 7.10323   1.000 25.96883 ?  174 SER A C   1 
ATOM   1140 O  O   . SER A 1 146 ? -47.99909 -63.33199 7.95762   1.000 29.79627 ?  174 SER A O   1 
ATOM   1141 C  CB  . SER A 1 146 ? -46.23052 -62.31922 5.68138   1.000 28.20937 ?  174 SER A CB  1 
ATOM   1142 O  OG  . SER A 1 146 ? -45.69157 -62.48610 4.37950   1.000 29.17330 ?  174 SER A OG  1 
ATOM   1143 N  N   . PHE A 1 147 ? -49.03981 -61.42967 7.35544   1.000 25.38786 ?  175 PHE A N   1 
ATOM   1144 C  CA  . PHE A 1 147 ? -49.66782 -61.16381 8.63535   1.000 27.18009 ?  175 PHE A CA  1 
ATOM   1145 C  C   . PHE A 1 147 ? -51.15083 -61.49816 8.56101   1.000 31.26754 ?  175 PHE A C   1 
ATOM   1146 O  O   . PHE A 1 147 ? -51.75183 -61.45980 7.48604   1.000 30.31834 ?  175 PHE A O   1 
ATOM   1147 C  CB  . PHE A 1 147 ? -49.46964 -59.69435 8.99826   1.000 27.44085 ?  175 PHE A CB  1 
ATOM   1148 C  CG  . PHE A 1 147 ? -48.03179 -59.25954 8.91132   1.000 24.44969 ?  175 PHE A CG  1 
ATOM   1149 C  CD1 . PHE A 1 147 ? -47.09338 -59.75622 9.81266   1.000 29.82036 ?  175 PHE A CD1 1 
ATOM   1150 C  CD2 . PHE A 1 147 ? -47.60282 -58.39981 7.90158   1.000 27.52800 ?  175 PHE A CD2 1 
ATOM   1151 C  CE1 . PHE A 1 147 ? -45.76818 -59.37386 9.72959   1.000 28.41087 ?  175 PHE A CE1 1 
ATOM   1152 C  CE2 . PHE A 1 147 ? -46.26726 -58.01212 7.81569   1.000 28.37983 ?  175 PHE A CE2 1 
ATOM   1153 C  CZ  . PHE A 1 147 ? -45.35359 -58.50620 8.73097   1.000 26.50487 ?  175 PHE A CZ  1 
ATOM   1154 N  N   . LYS A 1 148 ? -51.74021 -61.83941 9.70983   1.000 26.19420 ?  176 LYS A N   1 
ATOM   1155 C  CA  . LYS A 1 148 ? -53.19520 -61.99250 9.75124   1.000 25.53941 ?  176 LYS A CA  1 
ATOM   1156 C  C   . LYS A 1 148 ? -53.87965 -60.65003 9.56783   1.000 29.86760 ?  176 LYS A C   1 
ATOM   1157 O  O   . LYS A 1 148 ? -54.95914 -60.55782 8.96589   1.000 27.56111 ?  176 LYS A O   1 
ATOM   1158 C  CB  . LYS A 1 148 ? -53.63125 -62.63442 11.06935  1.000 26.83678 ?  176 LYS A CB  1 
ATOM   1159 C  CG  . LYS A 1 148 ? -53.15441 -64.05858 11.20948  1.000 25.54144 ?  176 LYS A CG  1 
ATOM   1160 C  CD  . LYS A 1 148 ? -53.81509 -64.77524 12.36913  1.000 27.81588 ?  176 LYS A CD  1 
ATOM   1161 C  CE  . LYS A 1 148 ? -53.36792 -66.24044 12.39773  1.000 26.95415 ?  176 LYS A CE  1 
ATOM   1162 N  NZ  . LYS A 1 148 ? -54.26719 -67.08852 13.24231  1.000 26.25729 ?  176 LYS A NZ  1 
ATOM   1163 N  N   . LEU A 1 149 ? -53.25739 -59.59699 10.08086  1.000 28.72813 ?  177 LEU A N   1 
ATOM   1164 C  CA  . LEU A 1 149 ? -53.76805 -58.24535 9.97524   1.000 25.51911 ?  177 LEU A CA  1 
ATOM   1165 C  C   . LEU A 1 149 ? -52.54718 -57.35345 9.88192   1.000 29.19154 ?  177 LEU A C   1 
ATOM   1166 O  O   . LEU A 1 149 ? -51.64201 -57.48437 10.70858  1.000 27.53198 ?  177 LEU A O   1 
ATOM   1167 C  CB  . LEU A 1 149 ? -54.61345 -57.88400 11.19023  1.000 26.18703 ?  177 LEU A CB  1 
ATOM   1168 C  CG  . LEU A 1 149 ? -55.17951 -56.47372 11.24177  1.000 29.81043 ?  177 LEU A CG  1 
ATOM   1169 C  CD1 . LEU A 1 149 ? -56.17533 -56.25992 10.10186  1.000 31.55048 ?  177 LEU A CD1 1 
ATOM   1170 C  CD2 . LEU A 1 149 ? -55.82670 -56.22604 12.58436  1.000 27.06759 ?  177 LEU A CD2 1 
ATOM   1171 N  N   . ALA A 1 150 ? -52.49005 -56.50813 8.85371   1.000 24.65938 ?  178 ALA A N   1 
ATOM   1172 C  CA  . ALA A 1 150 ? -51.38892 -55.55895 8.68248   1.000 24.80590 ?  178 ALA A CA  1 
ATOM   1173 C  C   . ALA A 1 150 ? -51.96108 -54.17503 8.95301   1.000 24.30757 ?  178 ALA A C   1 
ATOM   1174 O  O   . ALA A 1 150 ? -52.35370 -53.44677 8.03714   1.000 27.37861 ?  178 ALA A O   1 
ATOM   1175 C  CB  . ALA A 1 150 ? -50.76294 -55.66474 7.27704   1.000 27.19538 ?  178 ALA A CB  1 
ATOM   1176 N  N   . ALA A 1 151 ? -52.03823 -53.82593 10.24041  1.000 22.46972 ?  179 ALA A N   1 
ATOM   1177 C  CA  . ALA A 1 151 ? -52.68913 -52.60458 10.67570  1.000 21.88647 ?  179 ALA A CA  1 
ATOM   1178 C  C   . ALA A 1 151 ? -51.77448 -51.40126 10.47193  1.000 21.78137 ?  179 ALA A C   1 
ATOM   1179 O  O   . ALA A 1 151 ? -50.54219 -51.51132 10.51842  1.000 24.34849 ?  179 ALA A O   1 
ATOM   1180 C  CB  . ALA A 1 151 ? -53.09734 -52.72834 12.14460  1.000 22.90667 ?  179 ALA A CB  1 
ATOM   1181 N  N   A GLU A 1 152 ? -52.39504 -50.23714 10.25803  0.691 20.75085 ?  180 GLU A N   1 
ATOM   1182 N  N   B GLU A 1 152 ? -52.38481 -50.24659 10.21759  0.309 20.77949 ?  180 GLU A N   1 
ATOM   1183 C  CA  A GLU A 1 152 ? -51.67060 -49.04256 9.83430   0.691 19.54535 ?  180 GLU A CA  1 
ATOM   1184 C  CA  B GLU A 1 152 ? -51.64177 -49.04701 9.84235   0.309 19.68470 ?  180 GLU A CA  1 
ATOM   1185 C  C   A GLU A 1 152 ? -51.92751 -47.86085 10.75685  0.691 21.52294 ?  180 GLU A C   1 
ATOM   1186 C  C   B GLU A 1 152 ? -52.00295 -47.87405 10.74177  0.309 21.57163 ?  180 GLU A C   1 
ATOM   1187 O  O   A GLU A 1 152 ? -51.94546 -46.70882 10.31733  0.691 22.52184 ?  180 GLU A O   1 
ATOM   1188 O  O   B GLU A 1 152 ? -52.16726 -46.73928 10.28448  0.309 22.87799 ?  180 GLU A O   1 
ATOM   1189 C  CB  A GLU A 1 152 ? -52.03756 -48.69118 8.39456   0.691 23.71264 ?  180 GLU A CB  1 
ATOM   1190 C  CB  B GLU A 1 152 ? -51.86905 -48.71185 8.36674   0.309 23.95312 ?  180 GLU A CB  1 
ATOM   1191 C  CG  A GLU A 1 152 ? -51.64857 -49.79205 7.44603   0.691 25.16934 ?  180 GLU A CG  1 
ATOM   1192 C  CG  B GLU A 1 152 ? -51.32780 -49.79708 7.43839   0.309 25.98471 ?  180 GLU A CG  1 
ATOM   1193 C  CD  A GLU A 1 152 ? -51.98201 -49.45596 6.02103   0.691 33.08088 ?  180 GLU A CD  1 
ATOM   1194 C  CD  B GLU A 1 152 ? -51.41737 -49.45367 5.95862   0.309 32.01344 ?  180 GLU A CD  1 
ATOM   1195 O  OE1 A GLU A 1 152 ? -53.18616 -49.33413 5.72572   0.691 32.46816 ?  180 GLU A OE1 1 
ATOM   1196 O  OE1 B GLU A 1 152 ? -52.06407 -48.44693 5.59647   0.309 27.40834 ?  180 GLU A OE1 1 
ATOM   1197 O  OE2 A GLU A 1 152 ? -51.03885 -49.28832 5.21807   0.691 34.63862 ?  180 GLU A OE2 1 
ATOM   1198 O  OE2 B GLU A 1 152 ? -50.82063 -50.19998 5.15415   0.309 30.93259 ?  180 GLU A OE2 1 
ATOM   1199 N  N   . LEU A 1 153 ? -52.11602 -48.12708 12.04496  1.000 21.32985 ?  181 LEU A N   1 
ATOM   1200 C  CA  . LEU A 1 153 ? -52.41727 -47.05754 12.98288  1.000 21.70061 ?  181 LEU A CA  1 
ATOM   1201 C  C   . LEU A 1 153 ? -51.22470 -46.13187 13.18138  1.000 21.39976 ?  181 LEU A C   1 
ATOM   1202 O  O   . LEU A 1 153 ? -50.07751 -46.57911 13.23405  1.000 21.85997 ?  181 LEU A O   1 
ATOM   1203 C  CB  . LEU A 1 153 ? -52.80946 -47.63704 14.32964  1.000 22.71858 ?  181 LEU A CB  1 
ATOM   1204 C  CG  . LEU A 1 153 ? -54.05082 -48.51820 14.27744  1.000 24.62924 ?  181 LEU A CG  1 
ATOM   1205 C  CD1 . LEU A 1 153 ? -54.14563 -49.21219 15.62567  1.000 24.50845 ?  181 LEU A CD1 1 
ATOM   1206 C  CD2 . LEU A 1 153 ? -55.26425 -47.66125 14.02126  1.000 27.62596 ?  181 LEU A CD2 1 
ATOM   1207 N  N   . LYS A 1 154 ? -51.51256 -44.83926 13.33237  1.000 20.53920 ?  182 LYS A N   1 
ATOM   1208 C  CA  . LYS A 1 154 ? -50.47591 -43.88187 13.70071  1.000 21.25903 ?  182 LYS A CA  1 
ATOM   1209 C  C   . LYS A 1 154 ? -50.01851 -44.13304 15.13837  1.000 25.04229 ?  182 LYS A C   1 
ATOM   1210 O  O   . LYS A 1 154 ? -50.66836 -44.83870 15.90811  1.000 24.79146 ?  182 LYS A O   1 
ATOM   1211 C  CB  . LYS A 1 154 ? -50.98684 -42.44969 13.53572  1.000 25.66478 ?  182 LYS A CB  1 
ATOM   1212 C  CG  . LYS A 1 154 ? -51.92421 -42.00259 14.64484  1.000 34.58898 ?  182 LYS A CG  1 
ATOM   1213 C  CD  . LYS A 1 154 ? -52.78629 -40.80977 14.22249  1.000 40.04970 ?  182 LYS A CD  1 
ATOM   1214 C  CE  . LYS A 1 154 ? -53.28838 -40.03112 15.43522  1.000 40.44726 ?  182 LYS A CE  1 
ATOM   1215 N  NZ  . LYS A 1 154 ? -54.01272 -38.78050 15.04390  1.000 43.01641 ?  182 LYS A NZ  1 
ATOM   1216 N  N   . GLY A 1 155 ? -48.88110 -43.53165 15.50038  1.000 21.44993 ?  183 GLY A N   1 
ATOM   1217 C  CA  . GLY A 1 155 ? -48.21831 -43.90897 16.74006  1.000 18.92519 ?  183 GLY A CA  1 
ATOM   1218 C  C   . GLY A 1 155 ? -49.09111 -43.74961 17.97465  1.000 23.70081 ?  183 GLY A C   1 
ATOM   1219 O  O   . GLY A 1 155 ? -49.06702 -44.59256 18.87102  1.000 24.10595 ?  183 GLY A O   1 
ATOM   1220 N  N   . SER A 1 156 ? -49.88584 -42.68718 18.02841  1.000 23.41376 ?  184 SER A N   1 
ATOM   1221 C  CA  . SER A 1 156 ? -50.59174 -42.40184 19.28085  1.000 22.75686 ?  184 SER A CA  1 
ATOM   1222 C  C   . SER A 1 156 ? -51.81417 -43.28846 19.49522  1.000 29.87595 ?  184 SER A C   1 
ATOM   1223 O  O   . SER A 1 156 ? -52.43706 -43.20802 20.56024  1.000 28.49960 ?  184 SER A O   1 
ATOM   1224 C  CB  . SER A 1 156 ? -50.99407 -40.92571 19.32753  1.000 27.42823 ?  184 SER A CB  1 
ATOM   1225 O  OG  . SER A 1 156 ? -51.86430 -40.61088 18.26591  1.000 34.09486 ?  184 SER A OG  1 
ATOM   1226 N  N   . GLU A 1 157 ? -52.16063 -44.14193 18.53639  1.000 26.92047 ?  185 GLU A N   1 
ATOM   1227 C  CA  . GLU A 1 157 ? -53.27657 -45.07088 18.67472  1.000 22.74110 ?  185 GLU A CA  1 
ATOM   1228 C  C   . GLU A 1 157 ? -52.83739 -46.50865 18.91444  1.000 25.69426 ?  185 GLU A C   1 
ATOM   1229 O  O   . GLU A 1 157 ? -53.68799 -47.38112 19.13824  1.000 25.82298 ?  185 GLU A O   1 
ATOM   1230 C  CB  . GLU A 1 157 ? -54.17701 -44.97066 17.42923  1.000 27.94115 ?  185 GLU A CB  1 
ATOM   1231 C  CG  . GLU A 1 157 ? -54.63576 -43.53610 17.21652  1.000 31.34191 ?  185 GLU A CG  1 
ATOM   1232 C  CD  . GLU A 1 157 ? -55.67177 -43.35231 16.12497  1.000 51.46492 ?  185 GLU A CD  1 
ATOM   1233 O  OE1 . GLU A 1 157 ? -55.89371 -44.28297 15.32561  1.000 48.01941 ?  185 GLU A OE1 1 
ATOM   1234 O  OE2 . GLU A 1 157 ? -56.25713 -42.25022 16.06180  1.000 57.21471 ?  185 GLU A OE2 1 
ATOM   1235 N  N   . ARG A 1 158 ? -51.52810 -46.78212 18.92440  1.000 21.80579 ?  186 ARG A N   1 
ATOM   1236 C  CA  . ARG A 1 158 ? -51.05728 -48.16008 18.94759  1.000 20.23940 ?  186 ARG A CA  1 
ATOM   1237 C  C   . ARG A 1 158 ? -51.18366 -48.81137 20.32063  1.000 22.75162 ?  186 ARG A C   1 
ATOM   1238 O  O   . ARG A 1 158 ? -51.55310 -49.98774 20.41752  1.000 24.30157 ?  186 ARG A O   1 
ATOM   1239 C  CB  . ARG A 1 158 ? -49.60797 -48.20868 18.46337  1.000 22.48146 ?  186 ARG A CB  1 
ATOM   1240 C  CG  . ARG A 1 158 ? -49.52288 -47.78429 16.99156  1.000 19.62383 ?  186 ARG A CG  1 
ATOM   1241 C  CD  . ARG A 1 158 ? -48.08775 -47.62225 16.54395  1.000 20.81105 ?  186 ARG A CD  1 
ATOM   1242 N  NE  . ARG A 1 158 ? -48.04351 -46.97768 15.23792  1.000 20.02454 ?  186 ARG A NE  1 
ATOM   1243 C  CZ  . ARG A 1 158 ? -46.93292 -46.54663 14.66573  1.000 21.18688 ?  186 ARG A CZ  1 
ATOM   1244 N  NH1 . ARG A 1 158 ? -45.75525 -46.69272 15.25685  1.000 17.97595 ?  186 ARG A NH1 1 
ATOM   1245 N  NH2 . ARG A 1 158 ? -47.00357 -45.98170 13.45968  1.000 19.84143 ?  186 ARG A NH2 1 
ATOM   1246 N  N   . SER A 1 159 ? -50.85484 -48.09699 21.39299  1.000 24.01551 ?  187 SER A N   1 
ATOM   1247 C  CA  B SER A 1 159 ? -50.89807 -48.72500 22.70886  0.588 23.14525 ?  187 SER A CA  1 
ATOM   1248 C  CA  C SER A 1 159 ? -50.89164 -48.72136 22.70966  0.412 23.19674 ?  187 SER A CA  1 
ATOM   1249 C  C   . SER A 1 159 ? -52.32363 -49.11845 23.06998  1.000 25.58897 ?  187 SER A C   1 
ATOM   1250 O  O   . SER A 1 159 ? -52.55847 -50.20256 23.62226  1.000 27.25657 ?  187 SER A O   1 
ATOM   1251 C  CB  B SER A 1 159 ? -50.30999 -47.78616 23.76403  0.588 24.83988 ?  187 SER A CB  1 
ATOM   1252 C  CB  C SER A 1 159 ? -50.30213 -47.78990 23.77345  0.412 24.88312 ?  187 SER A CB  1 
ATOM   1253 O  OG  B SER A 1 159 ? -50.49157 -48.31381 25.06294  0.588 29.33356 ?  187 SER A OG  1 
ATOM   1254 O  OG  C SER A 1 159 ? -51.10501 -46.63804 23.94014  0.412 32.25372 ?  187 SER A OG  1 
ATOM   1255 N  N   . GLN A 1 160 ? -53.28460 -48.25110 22.75420  1.000 25.23501 ?  188 GLN A N   1 
ATOM   1256 C  CA  A GLN A 1 160 ? -54.68461 -48.58252 23.00741  0.617 31.44788 ?  188 GLN A CA  1 
ATOM   1257 C  CA  B GLN A 1 160 ? -54.68562 -48.57891 23.00268  0.383 31.44472 ?  188 GLN A CA  1 
ATOM   1258 C  C   . GLN A 1 160 ? -55.09755 -49.82132 22.22392  1.000 34.41890 ?  188 GLN A C   1 
ATOM   1259 O  O   . GLN A 1 160 ? -55.71412 -50.73734 22.77230  1.000 30.32705 ?  188 GLN A O   1 
ATOM   1260 C  CB  A GLN A 1 160 ? -55.58171 -47.39012 22.66713  0.617 32.11847 ?  188 GLN A CB  1 
ATOM   1261 C  CB  B GLN A 1 160 ? -55.57664 -47.38839 22.64237  0.383 32.13939 ?  188 GLN A CB  1 
ATOM   1262 C  CG  A GLN A 1 160 ? -56.99626 -47.48507 23.25524  0.617 38.07417 ?  188 GLN A CG  1 
ATOM   1263 C  CG  B GLN A 1 160 ? -56.88767 -47.34054 23.42178  0.383 38.08463 ?  188 GLN A CG  1 
ATOM   1264 C  CD  A GLN A 1 160 ? -57.04025 -47.25678 24.75981  0.617 33.71884 ?  188 GLN A CD  1 
ATOM   1265 C  CD  B GLN A 1 160 ? -58.03523 -46.77114 22.61106  0.383 32.99921 ?  188 GLN A CD  1 
ATOM   1266 O  OE1 A GLN A 1 160 ? -56.65437 -46.19597 25.25779  0.617 31.27999 ?  188 GLN A OE1 1 
ATOM   1267 O  OE1 B GLN A 1 160 ? -57.82572 -46.01756 21.65948  0.383 40.46218 ?  188 GLN A OE1 1 
ATOM   1268 N  NE2 A GLN A 1 160 ? -57.51490 -48.25877 25.49098  0.617 37.52875 ?  188 GLN A NE2 1 
ATOM   1269 N  NE2 B GLN A 1 160 ? -59.25925 -47.13933 22.97840  0.383 42.61912 ?  188 GLN A NE2 1 
ATOM   1270 N  N   . ALA A 1 161 ? -54.74705 -49.88219 20.93454  1.000 27.56199 ?  189 ALA A N   1 
ATOM   1271 C  CA  . ALA A 1 161 ? -55.12646 -51.05148 20.14879  1.000 27.87966 ?  189 ALA A CA  1 
ATOM   1272 C  C   . ALA A 1 161 ? -54.50449 -52.32588 20.69866  1.000 31.07028 ?  189 ALA A C   1 
ATOM   1273 O  O   . ALA A 1 161 ? -55.14435 -53.38334 20.70334  1.000 29.45097 ?  189 ALA A O   1 
ATOM   1274 C  CB  . ALA A 1 161 ? -54.72877 -50.85709 18.68599  1.000 26.62909 ?  189 ALA A CB  1 
ATOM   1275 N  N   . LEU A 1 162 ? -53.24524 -52.25684 21.14645  1.000 24.16431 ?  190 LEU A N   1 
ATOM   1276 C  CA  . LEU A 1 162 ? -52.58693 -53.44497 21.67076  1.000 26.16919 ?  190 LEU A CA  1 
ATOM   1277 C  C   . LEU A 1 162 ? -53.25420 -53.92148 22.95198  1.000 31.34793 ?  190 LEU A C   1 
ATOM   1278 O  O   . LEU A 1 162 ? -53.48183 -55.12619 23.13535  1.000 33.98395 ?  190 LEU A O   1 
ATOM   1279 C  CB  . LEU A 1 162 ? -51.11036 -53.15358 21.93335  1.000 28.81918 ?  190 LEU A CB  1 
ATOM   1280 C  CG  . LEU A 1 162 ? -50.26333 -54.34384 22.35808  1.000 27.17159 ?  190 LEU A CG  1 
ATOM   1281 C  CD1 . LEU A 1 162 ? -49.89898 -55.21835 21.16828  1.000 25.90092 ?  190 LEU A CD1 1 
ATOM   1282 C  CD2 . LEU A 1 162 ? -48.99294 -53.85238 23.03452  1.000 34.40320 ?  190 LEU A CD2 1 
ATOM   1283 N  N   A CYS A 1 163 ? -53.61560 -52.99318 23.83840  0.176 33.36805 ?  191 CYS A N   1 
ATOM   1284 N  N   B CYS A 1 163 ? -53.52235 -52.99368 23.86509  0.824 33.41046 ?  191 CYS A N   1 
ATOM   1285 C  CA  A CYS A 1 163 ? -54.23598 -53.40006 25.09312  0.176 37.71229 ?  191 CYS A CA  1 
ATOM   1286 C  CA  B CYS A 1 163 ? -54.09647 -53.38430 25.14122  0.824 38.26118 ?  191 CYS A CA  1 
ATOM   1287 C  C   A CYS A 1 163 ? -55.64308 -53.92760 24.87192  0.176 36.20446 ?  191 CYS A C   1 
ATOM   1288 C  C   B CYS A 1 163 ? -55.53209 -53.84917 24.97007  0.824 36.60798 ?  191 CYS A C   1 
ATOM   1289 O  O   A CYS A 1 163 ? -56.05572 -54.90059 25.51615  0.176 39.09309 ?  191 CYS A O   1 
ATOM   1290 O  O   B CYS A 1 163 ? -55.93881 -54.82434 25.61199  0.824 40.05906 ?  191 CYS A O   1 
ATOM   1291 C  CB  A CYS A 1 163 ? -54.27431 -52.23871 26.07281  0.176 36.73396 ?  191 CYS A CB  1 
ATOM   1292 C  CB  B CYS A 1 163 ? -53.99384 -52.23546 26.13726  0.824 38.24165 ?  191 CYS A CB  1 
ATOM   1293 S  SG  A CYS A 1 163 ? -55.43454 -50.90079 25.75641  0.176 34.51939 ?  191 CYS A SG  1 
ATOM   1294 S  SG  B CYS A 1 163 ? -52.26555 -51.80488 26.56967  0.824 52.03657 ?  191 CYS A SG  1 
ATOM   1295 N  N   A ASP A 1 164 ? -56.39546 -53.29498 23.97666  0.176 34.81200 ?  192 ASP A N   1 
ATOM   1296 N  N   B ASP A 1 164 ? -56.29883 -53.18866 24.08137  0.824 34.74538 ?  192 ASP A N   1 
ATOM   1297 C  CA  A ASP A 1 164 ? -57.75884 -53.70928 23.65916  0.176 33.87673 ?  192 ASP A CA  1 
ATOM   1298 C  CA  B ASP A 1 164 ? -57.66481 -53.59550 23.72756  0.824 33.83184 ?  192 ASP A CA  1 
ATOM   1299 C  C   A ASP A 1 164 ? -57.80983 -54.99585 22.87445  0.176 34.79317 ?  192 ASP A C   1 
ATOM   1300 C  C   B ASP A 1 164 ? -57.72436 -54.89576 22.94715  0.824 34.97590 ?  192 ASP A C   1 
ATOM   1301 O  O   A ASP A 1 164 ? -58.90447 -55.37657 22.43179  0.176 33.62637 ?  192 ASP A O   1 
ATOM   1302 O  O   B ASP A 1 164 ? -58.82602 -55.28134 22.52769  0.824 33.86967 ?  192 ASP A O   1 
ATOM   1303 C  CB  A ASP A 1 164 ? -58.47166 -52.59748 22.89053  0.176 35.93403 ?  192 ASP A CB  1 
ATOM   1304 C  CB  B ASP A 1 164 ? -58.37078 -52.51871 22.90814  0.824 35.96082 ?  192 ASP A CB  1 
ATOM   1305 C  CG  A ASP A 1 164 ? -58.84746 -51.43199 23.77624  0.176 36.09722 ?  192 ASP A CG  1 
ATOM   1306 C  CG  B ASP A 1 164 ? -58.82748 -51.36287 23.74232  0.824 35.85266 ?  192 ASP A CG  1 
ATOM   1307 O  OD1 A ASP A 1 164 ? -58.69464 -51.55531 25.01087  0.176 43.63584 ?  192 ASP A OD1 1 
ATOM   1308 O  OD1 B ASP A 1 164 ? -58.73771 -51.47243 24.98682  0.824 44.29200 ?  192 ASP A OD1 1 
ATOM   1309 O  OD2 A ASP A 1 164 ? -59.28786 -50.39443 23.24092  0.176 39.26791 ?  192 ASP A OD2 1 
ATOM   1310 O  OD2 B ASP A 1 164 ? -59.25967 -50.35087 23.15858  0.824 39.44276 ?  192 ASP A OD2 1 
ATOM   1311 N  N   A ASN A 1 165 ? -56.65563 -55.64378 22.70222  0.176 29.07517 ?  193 ASN A N   1 
ATOM   1312 N  N   B ASN A 1 165 ? -56.58885 -55.55459 22.71287  0.824 28.62579 ?  193 ASN A N   1 
ATOM   1313 C  CA  A ASN A 1 165 ? -56.56168 -56.92781 22.01743  0.176 32.45910 ?  193 ASN A CA  1 
ATOM   1314 C  CA  B ASN A 1 165 ? -56.55102 -56.85199 22.06385  0.824 32.49595 ?  193 ASN A CA  1 
ATOM   1315 C  C   A ASN A 1 165 ? -57.03501 -56.82720 20.57015  0.176 32.15929 ?  193 ASN A C   1 
ATOM   1316 C  C   B ASN A 1 165 ? -57.00964 -56.80408 20.61173  0.824 32.26350 ?  193 ASN A C   1 
ATOM   1317 O  O   A ASN A 1 165 ? -57.67589 -57.74029 20.04684  0.176 31.99607 ?  193 ASN A O   1 
ATOM   1318 O  O   B ASN A 1 165 ? -57.61225 -57.75864 20.11934  0.824 32.03827 ?  193 ASN A O   1 
ATOM   1319 C  CB  A ASN A 1 165 ? -57.33778 -58.01250 22.76890  0.176 32.06592 ?  193 ASN A CB  1 
ATOM   1320 C  CB  B ASN A 1 165 ? -57.38486 -57.87209 22.83558  0.824 32.28233 ?  193 ASN A CB  1 
ATOM   1321 C  CG  A ASN A 1 165 ? -56.80432 -59.40161 22.50165  0.176 31.19687 ?  193 ASN A CG  1 
ATOM   1322 C  CG  B ASN A 1 165 ? -56.97040 -59.26745 22.55123  0.824 30.56206 ?  193 ASN A CG  1 
ATOM   1323 O  OD1 A ASN A 1 165 ? -55.69609 -59.56941 21.99178  0.176 31.23451 ?  193 ASN A OD1 1 
ATOM   1324 O  OD1 B ASN A 1 165 ? -55.90024 -59.51317 21.98753  0.824 31.04453 ?  193 ASN A OD1 1 
ATOM   1325 N  ND2 A ASN A 1 165 ? -57.59461 -60.41287 22.84751  0.176 34.59754 ?  193 ASN A ND2 1 
ATOM   1326 N  ND2 B ASN A 1 165 ? -57.82839 -60.21622 22.91961  0.824 34.29223 ?  193 ASN A ND2 1 
ATOM   1327 N  N   . LYS A 1 166 ? -56.72255 -55.70777 19.91095  1.000 30.26341 ?  194 LYS A N   1 
ATOM   1328 C  CA  . LYS A 1 166 ? -56.98881 -55.61363 18.47838  1.000 26.71615 ?  194 LYS A CA  1 
ATOM   1329 C  C   . LYS A 1 166 ? -55.78147 -55.95329 17.62362  1.000 28.67693 ?  194 LYS A C   1 
ATOM   1330 O  O   . LYS A 1 166 ? -55.94595 -56.21098 16.42209  1.000 27.07781 ?  194 LYS A O   1 
ATOM   1331 C  CB  . LYS A 1 166 ? -57.49650 -54.22085 18.10058  1.000 26.14649 ?  194 LYS A CB  1 
ATOM   1332 C  CG  . LYS A 1 166 ? -58.81528 -53.81982 18.78425  1.000 33.14808 ?  194 LYS A CG  1 
ATOM   1333 C  CD  . LYS A 1 166 ? -59.22456 -52.41763 18.35009  1.000 43.04560 ?  194 LYS A CD  1 
ATOM   1334 C  CE  . LYS A 1 166 ? -60.64244 -52.04235 18.79036  1.000 56.33630 ?  194 LYS A CE  1 
ATOM   1335 N  NZ  . LYS A 1 166 ? -61.12955 -52.80573 19.97292  1.000 50.18413 ?  194 LYS A NZ  1 
ATOM   1336 N  N   . ILE A 1 167 ? -54.57743 -55.95067 18.20689  1.000 24.18368 ?  195 ILE A N   1 
ATOM   1337 C  CA  . ILE A 1 167 ? -53.36594 -56.41900 17.54952  1.000 25.29785 ?  195 ILE A CA  1 
ATOM   1338 C  C   . ILE A 1 167 ? -52.55005 -57.21277 18.55913  1.000 26.64997 ?  195 ILE A C   1 
ATOM   1339 O  O   . ILE A 1 167 ? -52.68106 -57.03322 19.77434  1.000 29.98774 ?  195 ILE A O   1 
ATOM   1340 C  CB  . ILE A 1 167 ? -52.53095 -55.24445 16.99566  1.000 25.87309 ?  195 ILE A CB  1 
ATOM   1341 C  CG1 . ILE A 1 167 ? -52.46664 -54.13170 18.03478  1.000 25.44190 ?  195 ILE A CG1 1 
ATOM   1342 C  CG2 . ILE A 1 167 ? -53.18534 -54.66603 15.77068  1.000 27.25893 ?  195 ILE A CG2 1 
ATOM   1343 C  CD1 . ILE A 1 167 ? -51.41900 -53.04589 17.71993  1.000 23.46932 ?  195 ILE A CD1 1 
ATOM   1344 N  N   . ASP A 1 168 ? -51.70869 -58.10274 18.03462  1.000 23.45621 ?  196 ASP A N   1 
ATOM   1345 C  CA  . ASP A 1 168 ? -50.75870 -58.85162 18.85376  1.000 23.92542 ?  196 ASP A CA  1 
ATOM   1346 C  C   . ASP A 1 168 ? -49.48742 -58.05697 19.14041  1.000 28.22052 ?  196 ASP A C   1 
ATOM   1347 O  O   . ASP A 1 168 ? -48.83942 -58.26856 20.17458  1.000 26.08830 ?  196 ASP A O   1 
ATOM   1348 C  CB  . ASP A 1 168 ? -50.37964 -60.14883 18.15486  1.000 27.07347 ?  196 ASP A CB  1 
ATOM   1349 C  CG  . ASP A 1 168 ? -51.56718 -61.05393 17.93367  1.000 37.82133 ?  196 ASP A CG  1 
ATOM   1350 O  OD1 . ASP A 1 168 ? -52.25057 -61.35694 18.93221  1.000 36.27423 ?  196 ASP A OD1 1 
ATOM   1351 O  OD2 . ASP A 1 168 ? -51.81147 -61.44832 16.77117  1.000 27.59431 ?  196 ASP A OD2 1 
ATOM   1352 N  N   . ALA A 1 169 ? -49.10748 -57.15807 18.23917  1.000 25.95327 ?  197 ALA A N   1 
ATOM   1353 C  CA  . ALA A 1 169 ? -47.88822 -56.38813 18.42765  1.000 22.53616 ?  197 ALA A CA  1 
ATOM   1354 C  C   . ALA A 1 169 ? -47.94680 -55.15547 17.54047  1.000 28.01253 ?  197 ALA A C   1 
ATOM   1355 O  O   . ALA A 1 169 ? -48.64650 -55.14496 16.52287  1.000 25.31599 ?  197 ALA A O   1 
ATOM   1356 C  CB  . ALA A 1 169 ? -46.64957 -57.21786 18.08671  1.000 24.31449 ?  197 ALA A CB  1 
ATOM   1357 N  N   . PHE A 1 170 ? -47.20879 -54.11744 17.93050  1.000 25.51986 ?  198 PHE A N   1 
ATOM   1358 C  CA  . PHE A 1 170 ? -46.93714 -53.01981 17.01295  1.000 19.53287 ?  198 PHE A CA  1 
ATOM   1359 C  C   . PHE A 1 170 ? -45.44160 -52.77495 16.94260  1.000 24.13104 ?  198 PHE A C   1 
ATOM   1360 O  O   . PHE A 1 170 ? -44.70913 -53.02709 17.89576  1.000 23.03346 ?  198 PHE A O   1 
ATOM   1361 C  CB  . PHE A 1 170 ? -47.70271 -51.70573 17.36799  1.000 19.80162 ?  198 PHE A CB  1 
ATOM   1362 C  CG  . PHE A 1 170 ? -47.37055 -51.07897 18.71598  1.000 24.13322 ?  198 PHE A CG  1 
ATOM   1363 C  CD1 . PHE A 1 170 ? -46.34853 -50.14062 18.83761  1.000 21.82400 ?  198 PHE A CD1 1 
ATOM   1364 C  CD2 . PHE A 1 170 ? -48.14226 -51.36153 19.83709  1.000 23.81996 ?  198 PHE A CD2 1 
ATOM   1365 C  CE1 . PHE A 1 170 ? -46.07560 -49.52691 20.05704  1.000 21.80131 ?  198 PHE A CE1 1 
ATOM   1366 C  CE2 . PHE A 1 170 ? -47.87123 -50.74920 21.07147  1.000 24.35240 ?  198 PHE A CE2 1 
ATOM   1367 C  CZ  . PHE A 1 170 ? -46.84250 -49.82792 21.17691  1.000 22.79000 ?  198 PHE A CZ  1 
ATOM   1368 N  N   . ILE A 1 171 ? -44.99069 -52.32505 15.79484  1.000 20.91178 ?  199 ILE A N   1 
ATOM   1369 C  CA  A ILE A 1 171 ? -43.59926 -51.92561 15.66987  0.959 22.42372 ?  199 ILE A CA  1 
ATOM   1370 C  CA  B ILE A 1 171 ? -43.60982 -51.91592 15.58253  0.041 22.38335 ?  199 ILE A CA  1 
ATOM   1371 C  C   . ILE A 1 171 ? -43.52824 -50.40873 15.78682  1.000 21.45318 ?  199 ILE A C   1 
ATOM   1372 O  O   . ILE A 1 171 ? -44.51789 -49.68902 15.62123  1.000 19.87979 ?  199 ILE A O   1 
ATOM   1373 C  CB  A ILE A 1 171 ? -42.93721 -52.44100 14.37124  0.959 23.83886 ?  199 ILE A CB  1 
ATOM   1374 C  CB  B ILE A 1 171 ? -43.14513 -52.35844 14.17574  0.041 23.33716 ?  199 ILE A CB  1 
ATOM   1375 C  CG1 A ILE A 1 171 ? -43.61865 -51.86158 13.13172  0.959 23.82057 ?  199 ILE A CG1 1 
ATOM   1376 C  CG1 B ILE A 1 171 ? -42.44659 -53.71424 14.26610  0.041 22.91302 ?  199 ILE A CG1 1 
ATOM   1377 C  CG2 A ILE A 1 171 ? -42.93423 -53.99929 14.33535  0.959 22.56645 ?  199 ILE A CG2 1 
ATOM   1378 C  CG2 B ILE A 1 171 ? -42.26221 -51.31261 13.49344  0.041 22.50286 ?  199 ILE A CG2 1 
ATOM   1379 C  CD1 A ILE A 1 171 ? -42.96035 -50.55975 12.60566  0.959 25.26737 ?  199 ILE A CD1 1 
ATOM   1380 C  CD1 B ILE A 1 171 ? -43.37982 -54.85371 14.57778  0.041 22.82669 ?  199 ILE A CD1 1 
ATOM   1381 N  N   . TYR A 1 172 ? -42.35120 -49.91456 16.16828  1.000 19.13571 ?  200 TYR A N   1 
ATOM   1382 C  CA  . TYR A 1 172 ? -42.18872 -48.47232 16.33436  1.000 19.31566 ?  200 TYR A CA  1 
ATOM   1383 C  C   . TYR A 1 172 ? -40.70898 -48.16847 16.21747  1.000 17.30765 ?  200 TYR A C   1 
ATOM   1384 O  O   . TYR A 1 172 ? -39.90105 -48.67860 17.00471  1.000 19.68787 ?  200 TYR A O   1 
ATOM   1385 C  CB  . TYR A 1 172 ? -42.74377 -47.98860 17.68996  1.000 21.37939 ?  200 TYR A CB  1 
ATOM   1386 C  CG  . TYR A 1 172 ? -43.34473 -46.58422 17.69341  1.000 21.42285 ?  200 TYR A CG  1 
ATOM   1387 C  CD1 . TYR A 1 172 ? -42.91188 -45.60526 16.80554  1.000 20.20467 ?  200 TYR A CD1 1 
ATOM   1388 C  CD2 . TYR A 1 172 ? -44.31310 -46.22175 18.63370  1.000 23.94784 ?  200 TYR A CD2 1 
ATOM   1389 C  CE1 . TYR A 1 172 ? -43.45319 -44.31496 16.82152  1.000 19.04854 ?  200 TYR A CE1 1 
ATOM   1390 C  CE2 . TYR A 1 172 ? -44.85669 -44.93426 18.66227  1.000 25.06469 ?  200 TYR A CE2 1 
ATOM   1391 C  CZ  . TYR A 1 172 ? -44.42615 -43.98517 17.76456  1.000 24.11535 ?  200 TYR A CZ  1 
ATOM   1392 O  OH  . TYR A 1 172 ? -44.96063 -42.72195 17.80183  1.000 23.87136 ?  200 TYR A OH  1 
ATOM   1393 N  N   . MET A 1 173 ? -40.36261 -47.35143 15.23434  1.000 18.63091 ?  201 MET A N   1 
ATOM   1394 C  CA  . MET A 1 173 ? -39.00133 -46.87870 15.00366  1.000 17.47743 ?  201 MET A CA  1 
ATOM   1395 C  C   . MET A 1 173 ? -38.91232 -45.61383 15.86018  1.000 16.54953 ?  201 MET A C   1 
ATOM   1396 O  O   . MET A 1 173 ? -39.36708 -44.55278 15.44068  1.000 18.06356 ?  201 MET A O   1 
ATOM   1397 C  CB  . MET A 1 173 ? -38.88459 -46.52811 13.52697  1.000 21.13642 ?  201 MET A CB  1 
ATOM   1398 C  CG  . MET A 1 173 ? -38.38305 -47.54655 12.52051  1.000 26.93850 ?  201 MET A CG  1 
ATOM   1399 S  SD  . MET A 1 173 ? -37.28283 -48.89555 12.89264  1.000 21.77702 ?  201 MET A SD  1 
ATOM   1400 C  CE  . MET A 1 173 ? -35.76808 -48.01677 12.85091  1.000 20.70485 ?  201 MET A CE  1 
ATOM   1401 N  N   . VAL A 1 174 ? -38.39677 -45.70408 17.08965  1.000 21.18225 ?  202 VAL A N   1 
ATOM   1402 C  CA  . VAL A 1 174 ? -38.53872 -44.57440 18.00428  1.000 21.37785 ?  202 VAL A CA  1 
ATOM   1403 C  C   . VAL A 1 174 ? -37.47222 -44.65252 19.08436  1.000 18.17838 ?  202 VAL A C   1 
ATOM   1404 O  O   . VAL A 1 174 ? -37.03496 -45.73736 19.47292  1.000 18.68544 ?  202 VAL A O   1 
ATOM   1405 C  CB  . VAL A 1 174 ? -39.97383 -44.51496 18.59649  1.000 22.21800 ?  202 VAL A CB  1 
ATOM   1406 C  CG1 . VAL A 1 174 ? -40.26599 -45.72184 19.43661  1.000 20.50663 ?  202 VAL A CG1 1 
ATOM   1407 C  CG2 . VAL A 1 174 ? -40.20254 -43.21982 19.39190  1.000 18.42701 ?  202 VAL A CG2 1 
ATOM   1408 N  N   . GLY A 1 175 ? -37.02952 -43.47933 19.54887  1.000 18.42384 ?  203 GLY A N   1 
ATOM   1409 C  CA  . GLY A 1 175 ? -36.11116 -43.39488 20.66503  1.000 20.20650 ?  203 GLY A CA  1 
ATOM   1410 C  C   . GLY A 1 175 ? -36.75182 -43.69189 22.01750  1.000 22.20117 ?  203 GLY A C   1 
ATOM   1411 O  O   . GLY A 1 175 ? -37.95229 -43.95410 22.15284  1.000 22.85405 ?  203 GLY A O   1 
ATOM   1412 N  N   . HIS A 1 176 ? -35.91023 -43.64268 23.04850  1.000 20.01230 ?  204 HIS A N   1 
ATOM   1413 C  CA  . HIS A 1 176 ? -36.29754 -44.07233 24.39130  1.000 19.79830 ?  204 HIS A CA  1 
ATOM   1414 C  C   . HIS A 1 176 ? -35.80204 -43.08728 25.43111  1.000 25.42944 ?  204 HIS A C   1 
ATOM   1415 O  O   . HIS A 1 176 ? -34.72368 -42.50249 25.27971  1.000 22.78260 ?  204 HIS A O   1 
ATOM   1416 C  CB  . HIS A 1 176 ? -35.72723 -45.44962 24.73951  1.000 22.25202 ?  204 HIS A CB  1 
ATOM   1417 C  CG  . HIS A 1 176 ? -36.17673 -46.52915 23.81442  1.000 20.98077 ?  204 HIS A CG  1 
ATOM   1418 N  ND1 . HIS A 1 176 ? -37.43767 -47.08687 23.87358  1.000 24.00912 ?  204 HIS A ND1 1 
ATOM   1419 C  CD2 . HIS A 1 176 ? -35.54042 -47.13084 22.78154  1.000 21.59855 ?  204 HIS A CD2 1 
ATOM   1420 C  CE1 . HIS A 1 176 ? -37.54473 -48.00986 22.93152  1.000 22.40019 ?  204 HIS A CE1 1 
ATOM   1421 N  NE2 . HIS A 1 176 ? -36.40835 -48.04924 22.25354  1.000 22.22099 ?  204 HIS A NE2 1 
ATOM   1422 N  N   . PRO A 1 177 ? -36.56783 -42.89682 26.51547  1.000 24.28391 ?  205 PRO A N   1 
ATOM   1423 C  CA  . PRO A 1 177 ? -37.91966 -43.44847 26.68604  1.000 21.96398 ?  205 PRO A CA  1 
ATOM   1424 C  C   . PRO A 1 177 ? -38.97911 -42.66985 25.90481  1.000 20.23679 ?  205 PRO A C   1 
ATOM   1425 O  O   . PRO A 1 177 ? -38.74326 -41.50862 25.57967  1.000 25.36553 ?  205 PRO A O   1 
ATOM   1426 C  CB  . PRO A 1 177 ? -38.14909 -43.31864 28.20169  1.000 28.23126 ?  205 PRO A CB  1 
ATOM   1427 C  CG  . PRO A 1 177 ? -37.34300 -42.11624 28.57624  1.000 29.28434 ?  205 PRO A CG  1 
ATOM   1428 C  CD  . PRO A 1 177 ? -36.10825 -42.16046 27.70928  1.000 26.87485 ?  205 PRO A CD  1 
ATOM   1429 N  N   . ASN A 1 178 ? -40.11806 -43.28608 25.57563  1.000 25.29367 ?  206 ASN A N   1 
ATOM   1430 C  CA  . ASN A 1 178 ? -41.21350 -42.54058 24.97025  1.000 23.19150 ?  206 ASN A CA  1 
ATOM   1431 C  C   . ASN A 1 178 ? -42.53906 -42.96642 25.59326  1.000 24.82258 ?  206 ASN A C   1 
ATOM   1432 O  O   . ASN A 1 178 ? -42.66439 -44.05497 26.16511  1.000 27.04457 ?  206 ASN A O   1 
ATOM   1433 C  CB  . ASN A 1 178 ? -41.29802 -42.71884 23.44267  1.000 26.71879 ?  206 ASN A CB  1 
ATOM   1434 C  CG  . ASN A 1 178 ? -41.64862 -44.12720 23.04801  1.000 28.76175 ?  206 ASN A CG  1 
ATOM   1435 O  OD1 . ASN A 1 178 ? -42.82744 -44.49237 23.00685  1.000 25.98047 ?  206 ASN A OD1 1 
ATOM   1436 N  ND2 . ASN A 1 178 ? -40.62469 -44.94394 22.76105  1.000 23.38671 ?  206 ASN A ND2 1 
ATOM   1437 N  N   . GLY A 1 179 ? -43.53901 -42.10444 25.40698  1.000 29.01506 ?  207 GLY A N   1 
ATOM   1438 C  CA  . GLY A 1 179 ? -44.80768 -42.28783 26.09580  1.000 32.26678 ?  207 GLY A CA  1 
ATOM   1439 C  C   . GLY A 1 179 ? -45.61810 -43.46026 25.57550  1.000 34.78852 ?  207 GLY A C   1 
ATOM   1440 O  O   . GLY A 1 179 ? -46.30294 -44.13438 26.34360  1.000 31.69155 ?  207 GLY A O   1 
ATOM   1441 N  N   . ALA A 1 180 ? -45.56145 -43.72218 24.26698  1.000 29.63071 ?  208 ALA A N   1 
ATOM   1442 C  CA  . ALA A 1 180 ? -46.34979 -44.82229 23.71945  1.000 27.62665 ?  208 ALA A CA  1 
ATOM   1443 C  C   . ALA A 1 180 ? -45.93241 -46.15667 24.32524  1.000 25.93845 ?  208 ALA A C   1 
ATOM   1444 O  O   . ALA A 1 180 ? -46.77794 -46.97303 24.70541  1.000 26.93214 ?  208 ALA A O   1 
ATOM   1445 C  CB  . ALA A 1 180 ? -46.21990 -44.85031 22.19162  1.000 25.24260 ?  208 ALA A CB  1 
ATOM   1446 N  N   . ILE A 1 181 ? -44.62648 -46.40298 24.43580  1.000 23.29749 ?  209 ILE A N   1 
ATOM   1447 C  CA  . ILE A 1 181 ? -44.18394 -47.68266 24.97123  1.000 21.00661 ?  209 ILE A CA  1 
ATOM   1448 C  C   . ILE A 1 181 ? -44.34148 -47.71956 26.48970  1.000 21.94761 ?  209 ILE A C   1 
ATOM   1449 O  O   . ILE A 1 181 ? -44.59074 -48.78603 27.06448  1.000 27.35460 ?  209 ILE A O   1 
ATOM   1450 C  CB  . ILE A 1 181 ? -42.73778 -47.97929 24.52254  1.000 23.26229 ?  209 ILE A CB  1 
ATOM   1451 C  CG1 . ILE A 1 181 ? -42.66481 -47.97616 22.98884  1.000 20.89368 ?  209 ILE A CG1 1 
ATOM   1452 C  CG2 . ILE A 1 181 ? -42.21416 -49.28552 25.09825  1.000 23.35811 ?  209 ILE A CG2 1 
ATOM   1453 C  CD1 . ILE A 1 181 ? -41.24992 -48.29897 22.43729  1.000 22.32495 ?  209 ILE A CD1 1 
ATOM   1454 N  N   . LYS A 1 182 ? -44.19699 -46.57390 27.14974  1.000 29.08927 ?  210 LYS A N   1 
ATOM   1455 C  CA  . LYS A 1 182 ? -44.42897 -46.54013 28.58933  1.000 27.33871 ?  210 LYS A CA  1 
ATOM   1456 C  C   . LYS A 1 182 ? -45.86699 -46.93985 28.90767  1.000 27.66150 ?  210 LYS A C   1 
ATOM   1457 O  O   . LYS A 1 182 ? -46.10443 -47.72875 29.82651  1.000 29.34298 ?  210 LYS A O   1 
ATOM   1458 C  CB  . LYS A 1 182 ? -44.09441 -45.15484 29.13748  1.000 33.07099 ?  210 LYS A CB  1 
ATOM   1459 C  CG  . LYS A 1 182 ? -44.06000 -45.07813 30.65893  1.000 47.25721 ?  210 LYS A CG  1 
ATOM   1460 C  CD  . LYS A 1 182 ? -43.40028 -43.78599 31.15516  1.000 53.72320 ?  210 LYS A CD  1 
ATOM   1461 C  CE  . LYS A 1 182 ? -42.12414 -43.45914 30.37928  1.000 58.08809 ?  210 LYS A CE  1 
ATOM   1462 N  NZ  . LYS A 1 182 ? -41.08283 -42.77352 31.22213  1.000 59.40167 ?  210 LYS A NZ  1 
ATOM   1463 N  N   A GLU A 1 183 ? -46.83339 -46.43591 28.13761  0.532 30.25844 ?  211 GLU A N   1 
ATOM   1464 N  N   B GLU A 1 183 ? -46.82697 -46.42843 28.13035  0.468 30.24703 ?  211 GLU A N   1 
ATOM   1465 C  CA  A GLU A 1 183 ? -48.23493 -46.75733 28.40954  0.532 33.25871 ?  211 GLU A CA  1 
ATOM   1466 C  CA  B GLU A 1 183 ? -48.24168 -46.72610 28.35929  0.468 33.28031 ?  211 GLU A CA  1 
ATOM   1467 C  C   A GLU A 1 183 ? -48.50258 -48.24750 28.24020  0.532 33.39950 ?  211 GLU A C   1 
ATOM   1468 C  C   B GLU A 1 183 ? -48.52527 -48.21821 28.21490  0.468 33.35358 ?  211 GLU A C   1 
ATOM   1469 O  O   A GLU A 1 183 ? -49.11079 -48.88737 29.10986  0.532 33.84714 ?  211 GLU A O   1 
ATOM   1470 O  O   B GLU A 1 183 ? -49.16049 -48.83169 29.08248  0.468 33.88461 ?  211 GLU A O   1 
ATOM   1471 C  CB  A GLU A 1 183 ? -49.15476 -45.94086 27.49781  0.532 32.26167 ?  211 GLU A CB  1 
ATOM   1472 C  CB  B GLU A 1 183 ? -49.10203 -45.90761 27.38591  0.468 32.17399 ?  211 GLU A CB  1 
ATOM   1473 C  CG  A GLU A 1 183 ? -50.64814 -46.11976 27.79257  0.532 35.35014 ?  211 GLU A CG  1 
ATOM   1474 C  CG  B GLU A 1 183 ? -49.04853 -44.39258 27.61820  0.468 33.73787 ?  211 GLU A CG  1 
ATOM   1475 C  CD  A GLU A 1 183 ? -51.07767 -45.50742 29.12525  0.532 36.43809 ?  211 GLU A CD  1 
ATOM   1476 C  CD  B GLU A 1 183 ? -49.73021 -43.57656 26.51628  0.468 45.41244 ?  211 GLU A CD  1 
ATOM   1477 O  OE1 A GLU A 1 183 ? -50.31185 -44.70642 29.69802  0.532 42.23306 ?  211 GLU A OE1 1 
ATOM   1478 O  OE1 B GLU A 1 183 ? -50.11495 -44.15773 25.48003  0.468 40.09664 ?  211 GLU A OE1 1 
ATOM   1479 O  OE2 A GLU A 1 183 ? -52.18844 -45.83004 29.60339  0.532 41.32895 ?  211 GLU A OE2 1 
ATOM   1480 O  OE2 B GLU A 1 183 ? -49.85326 -42.34070 26.67538  0.468 45.71220 ?  211 GLU A OE2 1 
ATOM   1481 N  N   . ALA A 1 184 ? -48.05851 -48.82298 27.11848  1.000 28.18730 ?  212 ALA A N   1 
ATOM   1482 C  CA  . ALA A 1 184 ? -48.33157 -50.23199 26.86487  1.000 27.86816 ?  212 ALA A CA  1 
ATOM   1483 C  C   . ALA A 1 184 ? -47.67831 -51.13442 27.90214  1.000 28.35013 ?  212 ALA A C   1 
ATOM   1484 O  O   . ALA A 1 184 ? -48.29516 -52.09856 28.37033  1.000 28.75889 ?  212 ALA A O   1 
ATOM   1485 C  CB  . ALA A 1 184 ? -47.85162 -50.61633 25.46326  1.000 27.33205 ?  212 ALA A CB  1 
ATOM   1486 N  N   A THR A 1 185 ? -46.45044 -50.79424 28.31329  0.523 27.76716 ?  213 THR A N   1 
ATOM   1487 N  N   B THR A 1 185 ? -46.40697 -50.89459 28.23269  0.477 27.86969 ?  213 THR A N   1 
ATOM   1488 C  CA  A THR A 1 185 ? -45.73238 -51.61557 29.27552  0.523 29.53047 ?  213 THR A CA  1 
ATOM   1489 C  CA  B THR A 1 185 ? -45.69843 -51.86273 29.06559  0.477 27.30279 ?  213 THR A CA  1 
ATOM   1490 C  C   A THR A 1 185 ? -46.21872 -51.36341 30.69838  0.523 22.94668 ?  213 THR A C   1 
ATOM   1491 C  C   B THR A 1 185 ? -46.26554 -51.92039 30.48043  0.477 30.13493 ?  213 THR A C   1 
ATOM   1492 O  O   A THR A 1 185 ? -46.35826 -52.30591 31.48270  0.523 31.91891 ?  213 THR A O   1 
ATOM   1493 O  O   B THR A 1 185 ? -46.28664 -52.99717 31.09491  0.477 27.25369 ?  213 THR A O   1 
ATOM   1494 C  CB  A THR A 1 185 ? -44.22263 -51.35479 29.18996  0.523 23.68048 ?  213 THR A CB  1 
ATOM   1495 C  CB  B THR A 1 185 ? -44.19945 -51.54192 29.09501  0.477 24.46799 ?  213 THR A CB  1 
ATOM   1496 O  OG1 A THR A 1 185 ? -43.95865 -49.95279 29.33367  0.523 26.34157 ?  213 THR A OG1 1 
ATOM   1497 O  OG1 B THR A 1 185 ? -43.99190 -50.19113 29.52260  0.477 26.26484 ?  213 THR A OG1 1 
ATOM   1498 C  CG2 A THR A 1 185 ? -43.68651 -51.83101 27.83815  0.523 23.53405 ?  213 THR A CG2 1 
ATOM   1499 C  CG2 B THR A 1 185 ? -43.59603 -51.74277 27.71328  0.477 23.55708 ?  213 THR A CG2 1 
ATOM   1500 N  N   A THR A 1 186 ? -46.48166 -50.11117 31.05568  0.523 30.26158 ?  214 THR A N   1 
ATOM   1501 N  N   B THR A 1 186 ? -46.74069 -50.79089 30.99180  0.477 26.73169 ?  214 THR A N   1 
ATOM   1502 C  CA  A THR A 1 186 ? -46.78893 -49.82029 32.44871  0.523 27.06921 ?  214 THR A CA  1 
ATOM   1503 C  CA  B THR A 1 186 ? -47.26995 -50.68055 32.34550  0.477 27.26055 ?  214 THR A CA  1 
ATOM   1504 C  C   A THR A 1 186 ? -48.28170 -49.81347 32.76074  0.523 28.64928 ?  214 THR A C   1 
ATOM   1505 C  C   B THR A 1 186 ? -48.77425 -50.86795 32.43210  0.477 33.70416 ?  214 THR A C   1 
ATOM   1506 O  O   A THR A 1 186 ? -48.63743 -49.91469 33.93804  0.523 27.04655 ?  214 THR A O   1 
ATOM   1507 O  O   B THR A 1 186 ? -49.33640 -50.63848 33.50675  0.477 34.58456 ?  214 THR A O   1 
ATOM   1508 C  CB  A THR A 1 186 ? -46.13795 -48.49240 32.87862  0.523 30.46760 ?  214 THR A CB  1 
ATOM   1509 C  CB  B THR A 1 186 ? -46.93025 -49.31401 32.95065  0.477 25.82899 ?  214 THR A CB  1 
ATOM   1510 O  OG1 A THR A 1 186 ? -45.64876 -48.61505 34.22205  0.523 46.07892 ?  214 THR A OG1 1 
ATOM   1511 O  OG1 B THR A 1 186 ? -47.43114 -48.26545 32.11147  0.477 36.47279 ?  214 THR A OG1 1 
ATOM   1512 C  CG2 A THR A 1 186 ? -47.11299 -47.32964 32.80112  0.523 35.32233 ?  214 THR A CG2 1 
ATOM   1513 C  CG2 B THR A 1 186 ? -45.45864 -49.15435 33.13983  0.477 30.40746 ?  214 THR A CG2 1 
ATOM   1514 N  N   A SER A 1 187 ? -49.16692 -49.75080 31.75327  0.523 25.81119 ?  215 SER A N   1 
ATOM   1515 N  N   B SER A 1 187 ? -49.44206 -51.22442 31.33812  0.477 22.03622 ?  215 SER A N   1 
ATOM   1516 C  CA  A SER A 1 187 ? -50.60163 -49.84909 32.00331  0.523 23.26905 ?  215 SER A CA  1 
ATOM   1517 C  CA  B SER A 1 187 ? -50.88991 -51.45689 31.38517  0.477 28.02572 ?  215 SER A CA  1 
ATOM   1518 C  C   A SER A 1 187 ? -51.28677 -51.04220 31.35084  0.523 26.88488 ?  215 SER A C   1 
ATOM   1519 C  C   B SER A 1 187 ? -51.28892 -52.84395 30.89998  0.477 30.47248 ?  215 SER A C   1 
ATOM   1520 O  O   A SER A 1 187 ? -52.46082 -51.28386 31.64141  0.523 29.66545 ?  215 SER A O   1 
ATOM   1521 O  O   B SER A 1 187 ? -52.21822 -53.43333 31.45733  0.477 27.02177 ?  215 SER A O   1 
ATOM   1522 C  CB  A SER A 1 187 ? -51.32815 -48.56963 31.55541  0.523 33.04185 ?  215 SER A CB  1 
ATOM   1523 C  CB  B SER A 1 187 ? -51.65997 -50.39931 30.55722  0.477 30.76699 ?  215 SER A CB  1 
ATOM   1524 O  OG  A SER A 1 187 ? -51.16233 -47.53546 32.50872  0.523 30.11380 ?  215 SER A OG  1 
ATOM   1525 O  OG  B SER A 1 187 ? -51.52109 -49.08907 31.08985  0.477 28.39875 ?  215 SER A OG  1 
ATOM   1526 N  N   A CYS A 1 188 ? -50.62645 -51.77129 30.45297  0.523 26.82662 ?  216 CYS A N   1 
ATOM   1527 N  N   B CYS A 1 188 ? -50.61499 -53.37046 29.87475  0.477 26.74950 ?  216 CYS A N   1 
ATOM   1528 C  CA  A CYS A 1 188 ? -51.30635 -52.93604 29.89875  0.523 26.41954 ?  216 CYS A CA  1 
ATOM   1529 C  CA  B CYS A 1 188 ? -50.93406 -54.64442 29.23238  0.477 26.02042 ?  216 CYS A CA  1 
ATOM   1530 C  C   A CYS A 1 188 ? -50.39345 -54.14304 29.71767  0.523 26.89934 ?  216 CYS A C   1 
ATOM   1531 C  C   B CYS A 1 188 ? -49.99240 -55.76905 29.64328  0.477 27.94334 ?  216 CYS A C   1 
ATOM   1532 O  O   A CYS A 1 188 ? -50.73378 -55.04538 28.94331  0.523 25.49371 ?  216 CYS A O   1 
ATOM   1533 O  O   B CYS A 1 188 ? -50.16119 -56.90023 29.17799  0.477 24.68450 ?  216 CYS A O   1 
ATOM   1534 C  CB  A CYS A 1 188 ? -51.99339 -52.59252 28.57876  0.523 28.45866 ?  216 CYS A CB  1 
ATOM   1535 C  CB  B CYS A 1 188 ? -50.88075 -54.48757 27.69504  0.477 23.05735 ?  216 CYS A CB  1 
ATOM   1536 S  SG  A CYS A 1 188 ? -52.68083 -50.90719 28.46106  0.523 27.69298 ?  216 CYS A SG  1 
ATOM   1537 S  SG  B CYS A 1 188 ? -51.91481 -55.57776 26.72464  0.477 44.72055 ?  216 CYS A SG  1 
ATOM   1538 N  N   A ALA A 1 189 ? -49.24776 -54.17153 30.40047  0.523 23.77781 ?  217 ALA A N   1 
ATOM   1539 N  N   B ALA A 1 189 ? -48.99657 -55.48560 30.48348  0.477 21.94617 ?  217 ALA A N   1 
ATOM   1540 C  CA  A ALA A 1 189 ? -48.40587 -55.36754 30.51647  0.523 22.32924 ?  217 ALA A CA  1 
ATOM   1541 C  CA  B ALA A 1 189 ? -47.81442 -56.33945 30.57890  0.477 24.87796 ?  217 ALA A CA  1 
ATOM   1542 C  C   A ALA A 1 189 ? -47.81974 -55.83380 29.17862  0.523 26.48993 ?  217 ALA A C   1 
ATOM   1543 C  C   B ALA A 1 189 ? -47.23081 -56.55901 29.18901  0.477 19.76698 ?  217 ALA A C   1 
ATOM   1544 O  O   A ALA A 1 189 ? -47.69643 -57.02932 28.94235  0.523 21.65141 ?  217 ALA A O   1 
ATOM   1545 O  O   B ALA A 1 189 ? -46.63529 -57.60430 28.89453  0.477 21.87605 ?  217 ALA A O   1 
ATOM   1546 C  CB  A ALA A 1 189 ? -49.17331 -56.51309 31.18767  0.523 27.11631 ?  217 ALA A CB  1 
ATOM   1547 C  CB  B ALA A 1 189 ? -48.12423 -57.66865 31.27031  0.477 22.75801 ?  217 ALA A CB  1 
ATOM   1548 N  N   A ALA A 1 190 ? -47.40322 -54.90560 28.31678  0.523 24.61811 ?  218 ALA A N   1 
ATOM   1549 N  N   B ALA A 1 190 ? -47.44435 -55.56146 28.32998  0.477 25.63889 ?  218 ALA A N   1 
ATOM   1550 C  CA  A ALA A 1 190 ? -46.75996 -55.32442 27.07488  0.523 25.93621 ?  218 ALA A CA  1 
ATOM   1551 C  CA  B ALA A 1 190 ? -46.79262 -55.51831 27.03727  0.477 25.76955 ?  218 ALA A CA  1 
ATOM   1552 C  C   A ALA A 1 190 ? -45.27649 -55.64316 27.30700  0.523 26.26244 ?  218 ALA A C   1 
ATOM   1553 C  C   B ALA A 1 190 ? -45.29254 -55.61088 27.23755  0.477 26.19318 ?  218 ALA A C   1 
ATOM   1554 O  O   A ALA A 1 190 ? -44.70185 -55.31124 28.35091  0.523 27.87839 ?  218 ALA A O   1 
ATOM   1555 O  O   B ALA A 1 190 ? -44.73586 -55.08826 28.21060  0.477 28.95865 ?  218 ALA A O   1 
ATOM   1556 C  CB  A ALA A 1 190 ? -46.91970 -54.24251 26.00891  0.523 24.56621 ?  218 ALA A CB  1 
ATOM   1557 C  CB  B ALA A 1 190 ? -47.15351 -54.23469 26.28784  0.477 23.95117 ?  218 ALA A CB  1 
ATOM   1558 N  N   . LYS A 1 191 ? -44.65291 -56.31102 26.32935  1.000 26.62403 ?  219 LYS A N   1 
ATOM   1559 C  CA  . LYS A 1 191 ? -43.23346 -56.60509 26.40450  1.000 28.46898 ?  219 LYS A CA  1 
ATOM   1560 C  C   . LYS A 1 191 ? -42.53073 -56.00818 25.19937  1.000 32.72029 ?  219 LYS A C   1 
ATOM   1561 O  O   . LYS A 1 191 ? -43.09891 -55.94899 24.10629  1.000 27.39413 ?  219 LYS A O   1 
ATOM   1562 C  CB  . LYS A 1 191 ? -42.97546 -58.10631 26.49165  1.000 29.80808 ?  219 LYS A CB  1 
ATOM   1563 C  CG  . LYS A 1 191 ? -43.55446 -58.96443 25.37579  1.000 39.60461 ?  219 LYS A CG  1 
ATOM   1564 C  CD  . LYS A 1 191 ? -42.87068 -60.33588 25.35397  1.000 46.20456 ?  219 LYS A CD  1 
ATOM   1565 C  CE  . LYS A 1 191 ? -43.76377 -61.41268 24.75043  1.000 41.18511 ?  219 LYS A CE  1 
ATOM   1566 N  NZ  . LYS A 1 191 ? -43.04353 -62.71095 24.56933  1.000 43.92194 ?  219 LYS A NZ  1 
ATOM   1567 N  N   . LEU A 1 192 ? -41.31188 -55.52422 25.42143  1.000 26.50947 ?  220 LEU A N   1 
ATOM   1568 C  CA  . LEU A 1 192 ? -40.41909 -55.18471 24.31763  1.000 25.32091 ?  220 LEU A CA  1 
ATOM   1569 C  C   . LEU A 1 192 ? -39.69868 -56.44896 23.86955  1.000 29.68037 ?  220 LEU A C   1 
ATOM   1570 O  O   . LEU A 1 192 ? -39.12041 -57.16657 24.69131  1.000 33.41973 ?  220 LEU A O   1 
ATOM   1571 C  CB  . LEU A 1 192 ? -39.42827 -54.10563 24.76326  1.000 27.24030 ?  220 LEU A CB  1 
ATOM   1572 C  CG  . LEU A 1 192 ? -38.65442 -53.22293 23.80220  1.000 34.89928 ?  220 LEU A CG  1 
ATOM   1573 C  CD1 . LEU A 1 192 ? -39.57977 -52.50429 22.84584  1.000 23.47393 ?  220 LEU A CD1 1 
ATOM   1574 C  CD2 . LEU A 1 192 ? -37.82530 -52.22493 24.60872  1.000 28.46495 ?  220 LEU A CD2 1 
ATOM   1575 N  N   . VAL A 1 193 ? -39.73982 -56.72659 22.57367  1.000 21.79369 ?  221 VAL A N   1 
ATOM   1576 C  CA  . VAL A 1 193 ? -39.30011 -57.99614 21.99922  1.000 23.46522 ?  221 VAL A CA  1 
ATOM   1577 C  C   . VAL A 1 193 ? -38.06717 -57.73914 21.14220  1.000 29.47408 ?  221 VAL A C   1 
ATOM   1578 O  O   . VAL A 1 193 ? -38.07885 -56.80551 20.33111  1.000 25.52513 ?  221 VAL A O   1 
ATOM   1579 C  CB  . VAL A 1 193 ? -40.41566 -58.64274 21.15138  1.000 25.83501 ?  221 VAL A CB  1 
ATOM   1580 C  CG1 . VAL A 1 193 ? -39.90465 -59.85497 20.41908  1.000 26.84490 ?  221 VAL A CG1 1 
ATOM   1581 C  CG2 . VAL A 1 193 ? -41.60676 -59.00009 22.04733  1.000 32.00612 ?  221 VAL A CG2 1 
ATOM   1582 N  N   . PRO A 1 194 ? -37.01508 -58.54680 21.25503  1.000 24.36202 ?  222 PRO A N   1 
ATOM   1583 C  CA  . PRO A 1 194 ? -35.82041 -58.32311 20.43036  1.000 25.31738 ?  222 PRO A CA  1 
ATOM   1584 C  C   . PRO A 1 194 ? -36.06349 -58.62064 18.95717  1.000 26.53866 ?  222 PRO A C   1 
ATOM   1585 O  O   . PRO A 1 194 ? -37.02854 -59.28673 18.56196  1.000 25.64616 ?  222 PRO A O   1 
ATOM   1586 C  CB  . PRO A 1 194 ? -34.78652 -59.29219 21.01473  1.000 27.27974 ?  222 PRO A CB  1 
ATOM   1587 C  CG  . PRO A 1 194 ? -35.60259 -60.33762 21.72989  1.000 33.59800 ?  222 PRO A CG  1 
ATOM   1588 C  CD  . PRO A 1 194 ? -36.81344 -59.62124 22.24672  1.000 30.85487 ?  222 PRO A CD  1 
ATOM   1589 N  N   . ALA A 1 195 ? -35.16540 -58.08483 18.13955  1.000 23.67825 ?  223 ALA A N   1 
ATOM   1590 C  CA  . ALA A 1 195 ? -35.08755 -58.40896 16.71195  1.000 22.83252 ?  223 ALA A CA  1 
ATOM   1591 C  C   . ALA A 1 195 ? -33.64824 -58.82916 16.42931  1.000 26.49569 ?  223 ALA A C   1 
ATOM   1592 O  O   . ALA A 1 195 ? -32.76595 -57.98147 16.24664  1.000 25.94380 ?  223 ALA A O   1 
ATOM   1593 C  CB  . ALA A 1 195 ? -35.51966 -57.23275 15.83702  1.000 23.76173 ?  223 ALA A CB  1 
ATOM   1594 N  N   . THR A 1 196 ? -33.41214 -60.14236 16.42370  1.000 24.35109 ?  224 THR A N   1 
ATOM   1595 C  CA  . THR A 1 196 ? -32.11430 -60.73037 16.12820  1.000 24.03930 ?  224 THR A CA  1 
ATOM   1596 C  C   . THR A 1 196 ? -32.29664 -61.85199 15.11436  1.000 26.77012 ?  224 THR A C   1 
ATOM   1597 O  O   . THR A 1 196 ? -33.41911 -62.23931 14.77090  1.000 28.19059 ?  224 THR A O   1 
ATOM   1598 C  CB  . THR A 1 196 ? -31.43114 -61.27572 17.39524  1.000 25.92960 ?  224 THR A CB  1 
ATOM   1599 O  OG1 . THR A 1 196 ? -32.20724 -62.36876 17.91778  1.000 28.74161 ?  224 THR A OG1 1 
ATOM   1600 C  CG2 . THR A 1 196 ? -31.30343 -60.18653 18.47046  1.000 29.49958 ?  224 THR A CG2 1 
ATOM   1601 N  N   . GLY A 1 197 ? -31.17848 -62.38496 14.64002  1.000 25.17711 ?  225 GLY A N   1 
ATOM   1602 C  CA  . GLY A 1 197 ? -31.20970 -63.47859 13.69641  1.000 26.73265 ?  225 GLY A CA  1 
ATOM   1603 C  C   . GLY A 1 197 ? -30.57176 -63.10611 12.37502  1.000 26.29809 ?  225 GLY A C   1 
ATOM   1604 O  O   . GLY A 1 197 ? -30.15366 -61.96392 12.16523  1.000 27.37018 ?  225 GLY A O   1 
ATOM   1605 N  N   . PRO A 1 198 ? -30.48859 -64.07002 11.45023  1.000 27.39857 ?  226 PRO A N   1 
ATOM   1606 C  CA  A PRO A 1 198 ? -29.75468 -63.81743 10.20294  0.466 26.06030 ?  226 PRO A CA  1 
ATOM   1607 C  CA  B PRO A 1 198 ? -29.75947 -63.82084 10.19953  0.534 26.05277 ?  226 PRO A CA  1 
ATOM   1608 C  C   . PRO A 1 198 ? -30.35700 -62.71298 9.35257   1.000 25.87680 ?  226 PRO A C   1 
ATOM   1609 O  O   . PRO A 1 198 ? -29.61580 -62.02007 8.64568   1.000 25.65217 ?  226 PRO A O   1 
ATOM   1610 C  CB  A PRO A 1 198 ? -29.80336 -65.17687 9.48883   0.466 29.54641 ?  226 PRO A CB  1 
ATOM   1611 C  CB  B PRO A 1 198 ? -29.82633 -65.17842 9.48164   0.534 29.56363 ?  226 PRO A CB  1 
ATOM   1612 C  CG  A PRO A 1 198 ? -30.98485 -65.86750 10.07109  0.466 24.93915 ?  226 PRO A CG  1 
ATOM   1613 C  CG  B PRO A 1 198 ? -30.09088 -66.16773 10.55792  0.534 29.01439 ?  226 PRO A CG  1 
ATOM   1614 C  CD  A PRO A 1 198 ? -31.04147 -65.43328 11.50359  0.466 27.64792 ?  226 PRO A CD  1 
ATOM   1615 C  CD  B PRO A 1 198 ? -30.97182 -65.45743 11.53778  0.534 27.61606 ?  226 PRO A CD  1 
ATOM   1616 N  N   . GLU A 1 199 ? -31.67519 -62.52680 9.39020   1.000 24.99558 ?  227 GLU A N   1 
ATOM   1617 C  CA  . GLU A 1 199 ? -32.28090 -61.46496 8.59589   1.000 25.95789 ?  227 GLU A CA  1 
ATOM   1618 C  C   . GLU A 1 199 ? -31.86013 -60.09078 9.10714   1.000 25.54942 ?  227 GLU A C   1 
ATOM   1619 O  O   . GLU A 1 199 ? -31.48852 -59.21590 8.31962   1.000 23.71720 ?  227 GLU A O   1 
ATOM   1620 C  CB  . GLU A 1 199 ? -33.80442 -61.61298 8.59820   1.000 23.82993 ?  227 GLU A CB  1 
ATOM   1621 C  CG  . GLU A 1 199 ? -34.30938 -62.92525 7.98074   1.000 24.19724 ?  227 GLU A CG  1 
ATOM   1622 C  CD  . GLU A 1 199 ? -34.30061 -64.11572 8.93692   1.000 30.93183 ?  227 GLU A CD  1 
ATOM   1623 O  OE1 . GLU A 1 199 ? -33.93386 -63.96837 10.11720  1.000 27.65169 ?  227 GLU A OE1 1 
ATOM   1624 O  OE2 . GLU A 1 199 ? -34.68717 -65.22198 8.49719   1.000 30.46656 ?  227 GLU A OE2 1 
ATOM   1625 N  N   . ILE A 1 200 ? -31.90537 -59.88065 10.42723  1.000 23.20902 ?  228 ILE A N   1 
ATOM   1626 C  CA  . ILE A 1 200 ? -31.47404 -58.59176 10.96830  1.000 23.75745 ?  228 ILE A CA  1 
ATOM   1627 C  C   . ILE A 1 200 ? -29.97949 -58.39797 10.74495  1.000 24.34940 ?  228 ILE A C   1 
ATOM   1628 O  O   . ILE A 1 200 ? -29.52372 -57.30328 10.39002  1.000 22.01863 ?  228 ILE A O   1 
ATOM   1629 C  CB  . ILE A 1 200 ? -31.84434 -58.48962 12.46092  1.000 25.14152 ?  228 ILE A CB  1 
ATOM   1630 C  CG1 . ILE A 1 200 ? -33.36749 -58.59703 12.64948  1.000 22.55625 ?  228 ILE A CG1 1 
ATOM   1631 C  CG2 . ILE A 1 200 ? -31.28592 -57.19584 13.07411  1.000 25.71414 ?  228 ILE A CG2 1 
ATOM   1632 C  CD1 . ILE A 1 200 ? -34.19201 -57.60234 11.85252  1.000 23.37021 ?  228 ILE A CD1 1 
ATOM   1633 N  N   . GLU A 1 201 ? -29.19488 -59.46152 10.91833  1.000 25.33787 ?  229 GLU A N   1 
ATOM   1634 C  CA  . GLU A 1 201 ? -27.75959 -59.35367 10.67497  1.000 23.66893 ?  229 GLU A CA  1 
ATOM   1635 C  C   . GLU A 1 201 ? -27.46747 -58.91649 9.24585   1.000 23.33925 ?  229 GLU A C   1 
ATOM   1636 O  O   . GLU A 1 201 ? -26.54675 -58.12786 9.01649   1.000 24.34875 ?  229 GLU A O   1 
ATOM   1637 C  CB  . GLU A 1 201 ? -27.07206 -60.68477 10.99636  1.000 27.96644 ?  229 GLU A CB  1 
ATOM   1638 C  CG  . GLU A 1 201 ? -27.05406 -60.98737 12.49840  1.000 28.18525 ?  229 GLU A CG  1 
ATOM   1639 C  CD  . GLU A 1 201 ? -26.59460 -62.39748 12.81354  1.000 40.47160 ?  229 GLU A CD  1 
ATOM   1640 O  OE1 . GLU A 1 201 ? -26.06647 -63.06662 11.89891  1.000 46.10950 ?  229 GLU A OE1 1 
ATOM   1641 O  OE2 . GLU A 1 201 ? -26.76568 -62.83087 13.97659  1.000 37.02898 ?  229 GLU A OE2 1 
ATOM   1642 N  N   . LYS A 1 202 ? -28.23487 -59.41922 8.26868   1.000 23.40298 ?  230 LYS A N   1 
ATOM   1643 C  CA  . LYS A 1 202 ? -28.03220 -58.99035 6.88732   1.000 23.36816 ?  230 LYS A CA  1 
ATOM   1644 C  C   . LYS A 1 202 ? -28.38102 -57.51718 6.72169   1.000 24.84498 ?  230 LYS A C   1 
ATOM   1645 O  O   . LYS A 1 202 ? -27.63699 -56.76616 6.08162   1.000 23.82767 ?  230 LYS A O   1 
ATOM   1646 C  CB  . LYS A 1 202 ? -28.85391 -59.86357 5.92795   1.000 26.34442 ?  230 LYS A CB  1 
ATOM   1647 C  CG  . LYS A 1 202 ? -28.80136 -59.42019 4.45942   1.000 31.95675 ?  230 LYS A CG  1 
ATOM   1648 C  CD  . LYS A 1 202 ? -29.60068 -60.35764 3.53254   1.000 39.73815 ?  230 LYS A CD  1 
ATOM   1649 C  CE  . LYS A 1 202 ? -31.11416 -60.20515 3.71325   1.000 41.11090 ?  230 LYS A CE  1 
ATOM   1650 N  NZ  . LYS A 1 202 ? -31.92212 -61.04218 2.74745   1.000 41.94715 ?  230 LYS A NZ  1 
ATOM   1651 N  N   . ILE A 1 203 ? -29.48392 -57.08055 7.33640   1.000 22.41662 ?  231 ILE A N   1 
ATOM   1652 C  CA  . ILE A 1 203 ? -29.89531 -55.68027 7.25789   1.000 23.39421 ?  231 ILE A CA  1 
ATOM   1653 C  C   . ILE A 1 203 ? -28.79245 -54.77022 7.79602   1.000 21.19704 ?  231 ILE A C   1 
ATOM   1654 O  O   . ILE A 1 203 ? -28.46721 -53.73672 7.19885   1.000 22.02618 ?  231 ILE A O   1 
ATOM   1655 C  CB  . ILE A 1 203 ? -31.22232 -55.48630 8.01930   1.000 22.07623 ?  231 ILE A CB  1 
ATOM   1656 C  CG1 . ILE A 1 203 ? -32.38538 -56.04215 7.19482   1.000 25.35984 ?  231 ILE A CG1 1 
ATOM   1657 C  CG2 . ILE A 1 203 ? -31.48694 -54.02072 8.30455   1.000 25.85462 ?  231 ILE A CG2 1 
ATOM   1658 C  CD1 . ILE A 1 203 ? -33.67907 -56.16837 7.98072   1.000 28.00982 ?  231 ILE A CD1 1 
ATOM   1659 N  N   . VAL A 1 204 ? -28.21296 -55.13367 8.94509   1.000 21.86881 ?  232 VAL A N   1 
ATOM   1660 C  CA  . VAL A 1 204 ? -27.15489 -54.31826 9.53928   1.000 21.03009 ?  232 VAL A CA  1 
ATOM   1661 C  C   . VAL A 1 204 ? -25.89190 -54.37268 8.68725   1.000 21.33726 ?  232 VAL A C   1 
ATOM   1662 O  O   . VAL A 1 204 ? -25.24294 -53.34643 8.44478   1.000 21.86240 ?  232 VAL A O   1 
ATOM   1663 C  CB  . VAL A 1 204 ? -26.87996 -54.77823 10.98417  1.000 18.94112 ?  232 VAL A CB  1 
ATOM   1664 C  CG1 . VAL A 1 204 ? -25.62048 -54.13259 11.53454  1.000 21.85360 ?  232 VAL A CG1 1 
ATOM   1665 C  CG2 . VAL A 1 204 ? -28.08914 -54.45237 11.87862  1.000 21.60415 ?  232 VAL A CG2 1 
ATOM   1666 N  N   . ALA A 1 205 ? -25.52930 -55.56931 8.20910   1.000 21.73271 ?  233 ALA A N   1 
ATOM   1667 C  CA  . ALA A 1 205 ? -24.29439 -55.70241 7.44040   1.000 20.56274 ?  233 ALA A CA  1 
ATOM   1668 C  C   . ALA A 1 205 ? -24.36334 -54.95780 6.11432   1.000 21.34070 ?  233 ALA A C   1 
ATOM   1669 O  O   . ALA A 1 205 ? -23.34177 -54.44794 5.63791   1.000 22.06245 ?  233 ALA A O   1 
ATOM   1670 C  CB  . ALA A 1 205 ? -23.99138 -57.17987 7.18100   1.000 23.36783 ?  233 ALA A CB  1 
ATOM   1671 N  N   . ASN A 1 206 ? -25.54299 -54.85840 5.51472   1.000 23.17245 ?  234 ASN A N   1 
ATOM   1672 C  CA  . ASN A 1 206 ? -25.64764 -54.40157 4.13480   1.000 21.89190 ?  234 ASN A CA  1 
ATOM   1673 C  C   . ASN A 1 206 ? -25.91387 -52.90594 3.98710   1.000 25.17880 ?  234 ASN A C   1 
ATOM   1674 O  O   . ASN A 1 206 ? -25.96489 -52.40938 2.85812   1.000 27.21355 ?  234 ASN A O   1 
ATOM   1675 C  CB  . ASN A 1 206 ? -26.73785 -55.19655 3.41555   1.000 23.14949 ?  234 ASN A CB  1 
ATOM   1676 C  CG  . ASN A 1 206 ? -26.27982 -56.59374 3.04384   1.000 24.36884 ?  234 ASN A CG  1 
ATOM   1677 O  OD1 . ASN A 1 206 ? -25.13970 -56.97806 3.31853   1.000 27.12445 ?  234 ASN A OD1 1 
ATOM   1678 N  ND2 . ASN A 1 206 ? -27.16872 -57.36593 2.43699   1.000 29.06702 ?  234 ASN A ND2 1 
ATOM   1679 N  N   . ASN A 1 207 ? -26.07419 -52.16351 5.08582   1.000 21.01303 ?  235 ASN A N   1 
ATOM   1680 C  CA  . ASN A 1 207 ? -26.52625 -50.78290 5.02229   1.000 22.71038 ?  235 ASN A CA  1 
ATOM   1681 C  C   . ASN A 1 207 ? -25.76452 -49.94449 6.04108   1.000 25.11973 ?  235 ASN A C   1 
ATOM   1682 O  O   . ASN A 1 207 ? -25.65328 -50.35512 7.21052   1.000 23.53455 ?  235 ASN A O   1 
ATOM   1683 C  CB  . ASN A 1 207 ? -28.03625 -50.71218 5.30495   1.000 21.07610 ?  235 ASN A CB  1 
ATOM   1684 C  CG  . ASN A 1 207 ? -28.86135 -51.49088 4.29585   1.000 24.49394 ?  235 ASN A CG  1 
ATOM   1685 O  OD1 . ASN A 1 207 ? -29.10507 -51.01654 3.17098   1.000 28.18187 ?  235 ASN A OD1 1 
ATOM   1686 N  ND2 . ASN A 1 207 ? -29.29006 -52.69087 4.67884   1.000 22.47150 ?  235 ASN A ND2 1 
ATOM   1687 N  N   . PRO A 1 208 ? -25.23947 -48.77670 5.65682   1.000 21.34995 ?  236 PRO A N   1 
ATOM   1688 C  CA  . PRO A 1 208 ? -24.46179 -47.99044 6.61595   1.000 22.94817 ?  236 PRO A CA  1 
ATOM   1689 C  C   . PRO A 1 208 ? -25.31511 -47.27835 7.65155   1.000 23.73410 ?  236 PRO A C   1 
ATOM   1690 O  O   . PRO A 1 208 ? -24.76172 -46.84636 8.66404   1.000 28.94160 ?  236 PRO A O   1 
ATOM   1691 C  CB  . PRO A 1 208 ? -23.70402 -46.98821 5.73339   1.000 28.56672 ?  236 PRO A CB  1 
ATOM   1692 C  CG  . PRO A 1 208 ? -24.48965 -46.89177 4.49777   1.000 26.40818 ?  236 PRO A CG  1 
ATOM   1693 C  CD  . PRO A 1 208 ? -25.19488 -48.19942 4.29572   1.000 23.84415 ?  236 PRO A CD  1 
ATOM   1694 N  N   . TYR A 1 209 ? -26.62851 -47.15493 7.44397   1.000 23.73834 ?  237 TYR A N   1 
ATOM   1695 C  CA  A TYR A 1 209 ? -27.51151 -46.45044 8.36803   0.623 22.42998 ?  237 TYR A CA  1 
ATOM   1696 C  CA  B TYR A 1 209 ? -27.49622 -46.45408 8.38519   0.377 22.43212 ?  237 TYR A CA  1 
ATOM   1697 C  C   . TYR A 1 209 ? -28.32229 -47.39549 9.25215   1.000 23.93858 ?  237 TYR A C   1 
ATOM   1698 O  O   . TYR A 1 209 ? -29.22323 -46.93137 9.96323   1.000 22.61101 ?  237 TYR A O   1 
ATOM   1699 C  CB  A TYR A 1 209 ? -28.46155 -45.52528 7.59268   0.623 22.96109 ?  237 TYR A CB  1 
ATOM   1700 C  CB  B TYR A 1 209 ? -28.41941 -45.48470 7.64117   0.377 22.94395 ?  237 TYR A CB  1 
ATOM   1701 C  CG  A TYR A 1 209 ? -28.86261 -46.08334 6.24747   0.623 21.26405 ?  237 TYR A CG  1 
ATOM   1702 C  CG  B TYR A 1 209 ? -28.76006 -45.92819 6.24303   0.377 21.38114 ?  237 TYR A CG  1 
ATOM   1703 C  CD1 A TYR A 1 209 ? -29.70971 -47.18264 6.16037   0.623 20.64500 ?  237 TYR A CD1 1 
ATOM   1704 C  CD1 B TYR A 1 209 ? -29.59110 -47.02043 6.01429   0.377 20.53604 ?  237 TYR A CD1 1 
ATOM   1705 C  CD2 A TYR A 1 209 ? -28.37451 -45.53823 5.06850   0.623 25.15804 ?  237 TYR A CD2 1 
ATOM   1706 C  CD2 B TYR A 1 209 ? -28.22864 -45.26814 5.14850   0.377 24.58403 ?  237 TYR A CD2 1 
ATOM   1707 C  CE1 A TYR A 1 209 ? -30.07776 -47.71397 4.94661   0.623 24.04497 ?  237 TYR A CE1 1 
ATOM   1708 C  CE1 B TYR A 1 209 ? -29.89304 -47.42742 4.72931   0.377 24.66923 ?  237 TYR A CE1 1 
ATOM   1709 C  CE2 A TYR A 1 209 ? -28.73531 -46.06735 3.84496   0.623 25.83809 ?  237 TYR A CE2 1 
ATOM   1710 C  CE2 B TYR A 1 209 ? -28.52028 -45.66475 3.87191   0.377 25.51016 ?  237 TYR A CE2 1 
ATOM   1711 C  CZ  A TYR A 1 209 ? -29.58623 -47.15573 3.79285   0.623 26.28917 ?  237 TYR A CZ  1 
ATOM   1712 C  CZ  B TYR A 1 209 ? -29.34864 -46.74074 3.66334   0.377 25.00840 ?  237 TYR A CZ  1 
ATOM   1713 O  OH  A TYR A 1 209 ? -29.95158 -47.70402 2.58967   0.623 26.34429 ?  237 TYR A OH  1 
ATOM   1714 O  OH  B TYR A 1 209 ? -29.61752 -47.11457 2.37372   0.377 20.83326 ?  237 TYR A OH  1 
ATOM   1715 N  N   . TYR A 1 210 ? -28.03800 -48.70137 9.22482   1.000 20.28892 ?  238 TYR A N   1 
ATOM   1716 C  CA  . TYR A 1 210 ? -28.61938 -49.64551 10.17961  1.000 21.11914 ?  238 TYR A CA  1 
ATOM   1717 C  C   . TYR A 1 210 ? -27.49824 -50.22920 11.03099  1.000 21.65179 ?  238 TYR A C   1 
ATOM   1718 O  O   . TYR A 1 210 ? -26.56103 -50.84056 10.50632  1.000 21.61680 ?  238 TYR A O   1 
ATOM   1719 C  CB  . TYR A 1 210 ? -29.40466 -50.76636 9.48755   1.000 19.53448 ?  238 TYR A CB  1 
ATOM   1720 C  CG  . TYR A 1 210 ? -30.57641 -50.28305 8.66857   1.000 21.32961 ?  238 TYR A CG  1 
ATOM   1721 C  CD1 . TYR A 1 210 ? -31.48320 -49.35745 9.17955   1.000 21.10845 ?  238 TYR A CD1 1 
ATOM   1722 C  CD2 . TYR A 1 210 ? -30.79732 -50.77630 7.38679   1.000 21.98867 ?  238 TYR A CD2 1 
ATOM   1723 C  CE1 . TYR A 1 210 ? -32.55502 -48.91485 8.41660   1.000 22.71569 ?  238 TYR A CE1 1 
ATOM   1724 C  CE2 . TYR A 1 210 ? -31.86873 -50.35887 6.62194   1.000 21.30844 ?  238 TYR A CE2 1 
ATOM   1725 C  CZ  . TYR A 1 210 ? -32.73426 -49.41813 7.12651   1.000 22.42136 ?  238 TYR A CZ  1 
ATOM   1726 O  OH  . TYR A 1 210 ? -33.79560 -49.01186 6.35651   1.000 22.76064 ?  238 TYR A OH  1 
ATOM   1727 N  N   . ALA A 1 211 ? -27.59473 -50.05437 12.34745  1.000 18.56393 ?  239 ALA A N   1 
ATOM   1728 C  CA  . ALA A 1 211 ? -26.59618 -50.56121 13.27256  1.000 18.17691 ?  239 ALA A CA  1 
ATOM   1729 C  C   . ALA A 1 211 ? -27.29664 -51.28422 14.41332  1.000 22.07568 ?  239 ALA A C   1 
ATOM   1730 O  O   . ALA A 1 211 ? -28.45366 -50.99565 14.73290  1.000 22.43829 ?  239 ALA A O   1 
ATOM   1731 C  CB  . ALA A 1 211 ? -25.72114 -49.42360 13.84250  1.000 22.57002 ?  239 ALA A CB  1 
ATOM   1732 N  N   . TYR A 1 212 ? -26.59025 -52.23091 15.01942  1.000 21.02094 ?  240 TYR A N   1 
ATOM   1733 C  CA  . TYR A 1 212 ? -27.13964 -52.92394 16.18199  1.000 21.15004 ?  240 TYR A CA  1 
ATOM   1734 C  C   . TYR A 1 212 ? -27.49341 -51.92548 17.28395  1.000 20.18428 ?  240 TYR A C   1 
ATOM   1735 O  O   . TYR A 1 212 ? -26.79189 -50.93149 17.49916  1.000 23.41005 ?  240 TYR A O   1 
ATOM   1736 C  CB  . TYR A 1 212 ? -26.13865 -53.94843 16.71259  1.000 20.47785 ?  240 TYR A CB  1 
ATOM   1737 C  CG  . TYR A 1 212 ? -25.90301 -55.13484 15.79244  1.000 21.92976 ?  240 TYR A CG  1 
ATOM   1738 C  CD1 . TYR A 1 212 ? -26.96471 -55.88900 15.29915  1.000 27.08155 ?  240 TYR A CD1 1 
ATOM   1739 C  CD2 . TYR A 1 212 ? -24.60874 -55.50398 15.42682  1.000 26.97485 ?  240 TYR A CD2 1 
ATOM   1740 C  CE1 . TYR A 1 212 ? -26.74313 -56.98565 14.45400  1.000 26.57892 ?  240 TYR A CE1 1 
ATOM   1741 C  CE2 . TYR A 1 212 ? -24.38064 -56.59945 14.59033  1.000 30.77811 ?  240 TYR A CE2 1 
ATOM   1742 C  CZ  . TYR A 1 212 ? -25.45011 -57.33015 14.11352  1.000 27.24255 ?  240 TYR A CZ  1 
ATOM   1743 O  OH  . TYR A 1 212 ? -25.22242 -58.41571 13.28539  1.000 31.16889 ?  240 TYR A OH  1 
ATOM   1744 N  N   . SER A 1 213 ? -28.59953 -52.19708 17.97194  1.000 22.09396 ?  241 SER A N   1 
ATOM   1745 C  CA  . SER A 1 213 ? -29.11102 -51.34441 19.03453  1.000 20.63128 ?  241 SER A CA  1 
ATOM   1746 C  C   . SER A 1 213 ? -29.38292 -52.19342 20.26485  1.000 21.93077 ?  241 SER A C   1 
ATOM   1747 O  O   . SER A 1 213 ? -29.54724 -53.41196 20.17725  1.000 22.22603 ?  241 SER A O   1 
ATOM   1748 C  CB  . SER A 1 213 ? -30.40151 -50.62644 18.60223  1.000 21.95090 ?  241 SER A CB  1 
ATOM   1749 O  OG  . SER A 1 213 ? -31.44537 -51.57161 18.38557  1.000 21.41614 ?  241 SER A OG  1 
ATOM   1750 N  N   . VAL A 1 214 ? -29.38681 -51.54380 21.43071  1.000 23.74603 ?  242 VAL A N   1 
ATOM   1751 C  CA  A VAL A 1 214 ? -29.73294 -52.19869 22.69055  0.656 25.02542 ?  242 VAL A CA  1 
ATOM   1752 C  CA  B VAL A 1 214 ? -29.74752 -52.20267 22.68131  0.344 25.04990 ?  242 VAL A CA  1 
ATOM   1753 C  C   . VAL A 1 214 ? -30.60222 -51.24668 23.49907  1.000 22.26408 ?  242 VAL A C   1 
ATOM   1754 O  O   . VAL A 1 214 ? -30.26068 -50.06977 23.65309  1.000 25.64780 ?  242 VAL A O   1 
ATOM   1755 C  CB  A VAL A 1 214 ? -28.48970 -52.59988 23.51252  0.656 27.30648 ?  242 VAL A CB  1 
ATOM   1756 C  CB  B VAL A 1 214 ? -28.51308 -52.65149 23.49123  0.344 27.30367 ?  242 VAL A CB  1 
ATOM   1757 C  CG1 A VAL A 1 214 ? -28.91187 -53.38556 24.75539  0.656 26.02622 ?  242 VAL A CG1 1 
ATOM   1758 C  CG1 B VAL A 1 214 ? -27.88850 -53.90260 22.88092  0.344 31.57731 ?  242 VAL A CG1 1 
ATOM   1759 C  CG2 A VAL A 1 214 ? -27.50423 -53.41348 22.67669  0.656 32.92197 ?  242 VAL A CG2 1 
ATOM   1760 C  CG2 B VAL A 1 214 ? -27.49247 -51.53045 23.58557  0.344 24.52533 ?  242 VAL A CG2 1 
ATOM   1761 N  N   . VAL A 1 215 ? -31.72447 -51.74123 24.00671  1.000 23.87448 ?  243 VAL A N   1 
ATOM   1762 C  CA  . VAL A 1 215 ? -32.51620 -51.01304 24.99689  1.000 27.02551 ?  243 VAL A CA  1 
ATOM   1763 C  C   . VAL A 1 215 ? -32.19013 -51.62708 26.35352  1.000 21.24582 ?  243 VAL A C   1 
ATOM   1764 O  O   . VAL A 1 215 ? -32.29957 -52.85166 26.49941  1.000 23.10658 ?  243 VAL A O   1 
ATOM   1765 C  CB  . VAL A 1 215 ? -34.02668 -51.07847 24.71499  1.000 22.90143 ?  243 VAL A CB  1 
ATOM   1766 C  CG1 . VAL A 1 215 ? -34.77917 -50.30125 25.78893  1.000 21.64953 ?  243 VAL A CG1 1 
ATOM   1767 C  CG2 . VAL A 1 215 ? -34.35388 -50.48398 23.33366  1.000 24.73522 ?  243 VAL A CG2 1 
ATOM   1768 N  N   . PRO A 1 216 ? -31.74553 -50.84325 27.33879  1.000 22.64499 ?  244 PRO A N   1 
ATOM   1769 C  CA  . PRO A 1 216 ? -31.27804 -51.43265 28.60315  1.000 24.13320 ?  244 PRO A CA  1 
ATOM   1770 C  C   . PRO A 1 216 ? -32.41391 -51.96579 29.46601  1.000 26.21188 ?  244 PRO A C   1 
ATOM   1771 O  O   . PRO A 1 216 ? -33.54908 -51.48928 29.40309  1.000 25.80286 ?  244 PRO A O   1 
ATOM   1772 C  CB  . PRO A 1 216 ? -30.57695 -50.25729 29.29646  1.000 21.19805 ?  244 PRO A CB  1 
ATOM   1773 C  CG  . PRO A 1 216 ? -31.23790 -49.04193 28.73424  1.000 25.97431 ?  244 PRO A CG  1 
ATOM   1774 C  CD  . PRO A 1 216 ? -31.52593 -49.38995 27.28278  1.000 24.54616 ?  244 PRO A CD  1 
ATOM   1775 N  N   . ALA A 1 217 ? -32.08537 -52.96980 30.28419  1.000 24.86439 ?  245 ALA A N   1 
ATOM   1776 C  CA  . ALA A 1 217 ? -33.02582 -53.45998 31.28470  1.000 23.58122 ?  245 ALA A CA  1 
ATOM   1777 C  C   . ALA A 1 217 ? -33.39101 -52.33453 32.24818  1.000 26.34011 ?  245 ALA A C   1 
ATOM   1778 O  O   . ALA A 1 217 ? -32.52796 -51.57824 32.69067  1.000 25.58686 ?  245 ALA A O   1 
ATOM   1779 C  CB  . ALA A 1 217 ? -32.41470 -54.63797 32.04577  1.000 26.43047 ?  245 ALA A CB  1 
ATOM   1780 N  N   . GLY A 1 218 ? -34.68364 -52.20845 32.56485  1.000 27.55482 ?  246 GLY A N   1 
ATOM   1781 C  CA  . GLY A 1 218 ? -35.15928 -51.12375 33.41017  1.000 26.86573 ?  246 GLY A CA  1 
ATOM   1782 C  C   . GLY A 1 218 ? -35.67035 -49.89221 32.68309  1.000 27.26858 ?  246 GLY A C   1 
ATOM   1783 O  O   . GLY A 1 218 ? -36.21667 -48.99036 33.32897  1.000 29.99088 ?  246 GLY A O   1 
ATOM   1784 N  N   . MET A 1 219 ? -35.49967 -49.80262 31.35995  1.000 25.16431 ?  247 MET A N   1 
ATOM   1785 C  CA  . MET A 1 219 ? -36.08702 -48.68603 30.62471  1.000 22.75339 ?  247 MET A CA  1 
ATOM   1786 C  C   . MET A 1 219 ? -37.60114 -48.66053 30.82556  1.000 21.33395 ?  247 MET A C   1 
ATOM   1787 O  O   . MET A 1 219 ? -38.20740 -47.58779 30.93729  1.000 25.48253 ?  247 MET A O   1 
ATOM   1788 C  CB  . MET A 1 219 ? -35.77965 -48.84779 29.13362  1.000 22.55124 ?  247 MET A CB  1 
ATOM   1789 C  CG  . MET A 1 219 ? -35.84234 -47.64096 28.16383  1.000 23.18998 ?  247 MET A CG  1 
ATOM   1790 S  SD  . MET A 1 219 ? -35.47684 -45.99368 28.68308  1.000 30.58897 ?  247 MET A SD  1 
ATOM   1791 C  CE  . MET A 1 219 ? -33.71643 -45.97374 28.36254  1.000 34.74291 ?  247 MET A CE  1 
ATOM   1792 N  N   . TYR A 1 220 ? -38.22442 -49.84905 30.84940  1.000 25.71731 ?  248 TYR A N   1 
ATOM   1793 C  CA  . TYR A 1 220 ? -39.66917 -50.02083 30.94341  1.000 26.37508 ?  248 TYR A CA  1 
ATOM   1794 C  C   . TYR A 1 220 ? -40.00495 -51.13362 31.92538  1.000 22.57844 ?  248 TYR A C   1 
ATOM   1795 O  O   . TYR A 1 220 ? -39.28334 -52.12995 32.03540  1.000 27.14653 ?  248 TYR A O   1 
ATOM   1796 C  CB  . TYR A 1 220 ? -40.30222 -50.36616 29.58115  1.000 20.94076 ?  248 TYR A CB  1 
ATOM   1797 C  CG  . TYR A 1 220 ? -40.06351 -49.31812 28.52608  1.000 21.89650 ?  248 TYR A CG  1 
ATOM   1798 C  CD1 . TYR A 1 220 ? -40.70365 -48.08741 28.58817  1.000 21.83128 ?  248 TYR A CD1 1 
ATOM   1799 C  CD2 . TYR A 1 220 ? -39.17334 -49.54181 27.47871  1.000 25.60565 ?  248 TYR A CD2 1 
ATOM   1800 C  CE1 . TYR A 1 220 ? -40.48166 -47.10618 27.64771  1.000 26.58926 ?  248 TYR A CE1 1 
ATOM   1801 C  CE2 . TYR A 1 220 ? -38.94281 -48.56204 26.52338  1.000 24.24535 ?  248 TYR A CE2 1 
ATOM   1802 C  CZ  . TYR A 1 220 ? -39.59511 -47.35075 26.60712  1.000 24.94707 ?  248 TYR A CZ  1 
ATOM   1803 O  OH  . TYR A 1 220 ? -39.39130 -46.35755 25.67351  1.000 22.55841 ?  248 TYR A OH  1 
ATOM   1804 N  N   . SER A 1 221 ? -41.13274 -50.96795 32.62166  1.000 26.79020 ?  249 SER A N   1 
ATOM   1805 C  CA  A SER A 1 221 ? -41.61492 -52.02143 33.50385  0.438 31.03683 ?  249 SER A CA  1 
ATOM   1806 C  CA  B SER A 1 221 ? -41.62684 -52.01681 33.50077  0.562 31.05687 ?  249 SER A CA  1 
ATOM   1807 C  C   . SER A 1 221 ? -41.77033 -53.32117 32.73014  1.000 31.38582 ?  249 SER A C   1 
ATOM   1808 O  O   . SER A 1 221 ? -42.29432 -53.33765 31.61334  1.000 29.31543 ?  249 SER A O   1 
ATOM   1809 C  CB  A SER A 1 221 ? -42.94975 -51.62541 34.14608  0.438 32.50806 ?  249 SER A CB  1 
ATOM   1810 C  CB  B SER A 1 221 ? -42.97309 -51.58938 34.10029  0.562 32.47945 ?  249 SER A CB  1 
ATOM   1811 O  OG  A SER A 1 221 ? -43.04672 -50.22877 34.34577  0.438 38.79687 ?  249 SER A OG  1 
ATOM   1812 O  OG  B SER A 1 221 ? -43.61067 -52.65601 34.77803  0.562 38.82944 ?  249 SER A OG  1 
ATOM   1813 N  N   . GLY A 1 222 ? -41.27716 -54.40871 33.31173  1.000 27.92566 ?  250 GLY A N   1 
ATOM   1814 C  CA  . GLY A 1 222 ? -41.46223 -55.72590 32.74867  1.000 36.85878 ?  250 GLY A CA  1 
ATOM   1815 C  C   . GLY A 1 222 ? -40.40919 -56.18082 31.75911  1.000 31.48785 ?  250 GLY A C   1 
ATOM   1816 O  O   . GLY A 1 222 ? -40.33348 -57.37922 31.46448  1.000 46.99958 ?  250 GLY A O   1 
ATOM   1817 N  N   . THR A 1 223 ? -39.60587 -55.28024 31.22305  1.000 28.38941 ?  251 THR A N   1 
ATOM   1818 C  CA  . THR A 1 223 ? -38.50853 -55.68418 30.34868  1.000 36.59880 ?  251 THR A CA  1 
ATOM   1819 C  C   . THR A 1 223 ? -37.26027 -55.69610 31.22402  1.000 33.13701 ?  251 THR A C   1 
ATOM   1820 O  O   . THR A 1 223 ? -36.61180 -54.67682 31.46366  1.000 30.66062 ?  251 THR A O   1 
ATOM   1821 C  CB  . THR A 1 223 ? -38.42879 -54.79948 29.10614  1.000 44.74798 ?  251 THR A CB  1 
ATOM   1822 O  OG1 . THR A 1 223 ? -38.16469 -53.43591 29.47302  1.000 50.48734 ?  251 THR A OG1 1 
ATOM   1823 C  CG2 . THR A 1 223 ? -39.75130 -54.91986 28.29983  1.000 35.21117 ?  251 THR A CG2 1 
ATOM   1824 N  N   . ASP A 1 224 ? -36.95854 -56.88085 31.74093  1.000 26.20258 ?  252 ASP A N   1 
ATOM   1825 C  CA  . ASP A 1 224 ? -35.99318 -57.04963 32.81205  1.000 29.30339 ?  252 ASP A CA  1 
ATOM   1826 C  C   . ASP A 1 224 ? -34.65445 -57.56432 32.30581  1.000 34.09203 ?  252 ASP A C   1 
ATOM   1827 O  O   . ASP A 1 224 ? -33.75711 -57.82873 33.10835  1.000 31.26240 ?  252 ASP A O   1 
ATOM   1828 C  CB  . ASP A 1 224 ? -36.58263 -57.99219 33.86463  1.000 26.59148 ?  252 ASP A CB  1 
ATOM   1829 C  CG  . ASP A 1 224 ? -37.87722 -57.45343 34.47611  1.000 26.85611 ?  252 ASP A CG  1 
ATOM   1830 O  OD1 . ASP A 1 224 ? -38.06431 -56.22045 34.52200  1.000 26.40682 ?  252 ASP A OD1 1 
ATOM   1831 O  OD2 . ASP A 1 224 ? -38.71092 -58.27161 34.92180  1.000 29.48585 ?  252 ASP A OD2 1 
ATOM   1832 N  N   . GLN A 1 225 ? -34.50996 -57.71873 30.99190  1.000 28.42645 ?  253 GLN A N   1 
ATOM   1833 C  CA  . GLN A 1 225 ? -33.22873 -57.97006 30.35719  1.000 24.64751 ?  253 GLN A CA  1 
ATOM   1834 C  C   . GLN A 1 225 ? -33.09402 -56.99405 29.20123  1.000 27.59617 ?  253 GLN A C   1 
ATOM   1835 O  O   . GLN A 1 225 ? -34.08326 -56.44797 28.71476  1.000 27.31716 ?  253 GLN A O   1 
ATOM   1836 C  CB  . GLN A 1 225 ? -33.09415 -59.41219 29.84757  1.000 31.68749 ?  253 GLN A CB  1 
ATOM   1837 C  CG  . GLN A 1 225 ? -32.64382 -60.41095 30.90654  1.000 54.82753 ?  253 GLN A CG  1 
ATOM   1838 C  CD  . GLN A 1 225 ? -33.80024 -60.98576 31.70774  1.000 71.85238 ?  253 GLN A CD  1 
ATOM   1839 O  OE1 . GLN A 1 225 ? -34.96313 -60.91143 31.29235  1.000 62.85836 ?  253 GLN A OE1 1 
ATOM   1840 N  NE2 . GLN A 1 225 ? -33.48697 -61.55885 32.86876  1.000 71.00845 ?  253 GLN A NE2 1 
ATOM   1841 N  N   . GLU A 1 226 ? -31.85876 -56.75085 28.78232  1.000 23.71057 ?  254 GLU A N   1 
ATOM   1842 C  CA  . GLU A 1 226 ? -31.66733 -55.84613 27.66167  1.000 25.74355 ?  254 GLU A CA  1 
ATOM   1843 C  C   . GLU A 1 226 ? -32.27190 -56.44980 26.38812  1.000 25.11668 ?  254 GLU A C   1 
ATOM   1844 O  O   . GLU A 1 226 ? -32.43904 -57.66638 26.25879  1.000 26.35707 ?  254 GLU A O   1 
ATOM   1845 C  CB  . GLU A 1 226 ? -30.18185 -55.52311 27.49852  1.000 27.11947 ?  254 GLU A CB  1 
ATOM   1846 C  CG  . GLU A 1 226 ? -29.35413 -56.62206 26.91822  1.000 30.73159 ?  254 GLU A CG  1 
ATOM   1847 C  CD  . GLU A 1 226 ? -27.89538 -56.20937 26.79325  1.000 39.18362 ?  254 GLU A CD  1 
ATOM   1848 O  OE1 . GLU A 1 226 ? -27.54336 -55.11303 27.28162  1.000 38.86473 ?  254 GLU A OE1 1 
ATOM   1849 O  OE2 . GLU A 1 226 ? -27.11542 -56.97139 26.19401  1.000 48.71116 ?  254 GLU A OE2 1 
ATOM   1850 N  N   . VAL A 1 227 ? -32.63379 -55.57443 25.44897  1.000 23.06504 ?  255 VAL A N   1 
ATOM   1851 C  CA  . VAL A 1 227 ? -33.33452 -55.96823 24.22536  1.000 24.27742 ?  255 VAL A CA  1 
ATOM   1852 C  C   . VAL A 1 227 ? -32.50519 -55.50719 23.03763  1.000 21.43946 ?  255 VAL A C   1 
ATOM   1853 O  O   . VAL A 1 227 ? -32.33345 -54.29981 22.83317  1.000 22.14731 ?  255 VAL A O   1 
ATOM   1854 C  CB  . VAL A 1 227 ? -34.74757 -55.36790 24.16374  1.000 24.51777 ?  255 VAL A CB  1 
ATOM   1855 C  CG1 . VAL A 1 227 ? -35.43004 -55.73349 22.84356  1.000 23.86014 ?  255 VAL A CG1 1 
ATOM   1856 C  CG2 . VAL A 1 227 ? -35.59166 -55.88834 25.32057  1.000 28.23474 ?  255 VAL A CG2 1 
ATOM   1857 N  N   . LYS A 1 228 ? -32.01972 -56.45649 22.24392  1.000 23.19920 ?  256 LYS A N   1 
ATOM   1858 C  CA  . LYS A 1 228 ? -31.22616 -56.11782 21.06518  1.000 21.96572 ?  256 LYS A CA  1 
ATOM   1859 C  C   . LYS A 1 228 ? -32.11361 -56.02079 19.83768  1.000 22.07754 ?  256 LYS A C   1 
ATOM   1860 O  O   . LYS A 1 228 ? -33.08060 -56.77258 19.69542  1.000 22.40396 ?  256 LYS A O   1 
ATOM   1861 C  CB  . LYS A 1 228 ? -30.11671 -57.14613 20.82093  1.000 25.35028 ?  256 LYS A CB  1 
ATOM   1862 C  CG  . LYS A 1 228 ? -29.25808 -57.43891 22.04547  1.000 38.53470 ?  256 LYS A CG  1 
ATOM   1863 C  CD  . LYS A 1 228 ? -28.02177 -58.26463 21.68559  1.000 56.76941 ?  256 LYS A CD  1 
ATOM   1864 C  CE  . LYS A 1 228 ? -28.34442 -59.74423 21.53612  1.000 71.60901 ?  256 LYS A CE  1 
ATOM   1865 N  NZ  . LYS A 1 228 ? -27.46256 -60.61680 22.36805  1.000 78.94167 ?  256 LYS A NZ  1 
ATOM   1866 N  N   . SER A 1 229 ? -31.78019 -55.07460 18.95819  1.000 20.37197 ?  257 SER A N   1 
ATOM   1867 C  CA  . SER A 1 229 ? -32.44879 -54.93107 17.67005  1.000 20.35470 ?  257 SER A CA  1 
ATOM   1868 C  C   . SER A 1 229 ? -31.46855 -54.25480 16.71967  1.000 19.88586 ?  257 SER A C   1 
ATOM   1869 O  O   . SER A 1 229 ? -30.25361 -54.43653 16.85517  1.000 20.90824 ?  257 SER A O   1 
ATOM   1870 C  CB  . SER A 1 229 ? -33.74440 -54.12813 17.82379  1.000 20.22189 ?  257 SER A CB  1 
ATOM   1871 O  OG  . SER A 1 229 ? -34.49744 -54.06026 16.61313  1.000 20.65060 ?  257 SER A OG  1 
ATOM   1872 N  N   . PHE A 1 230 ? -31.97486 -53.50668 15.74576  1.000 21.01131 ?  258 PHE A N   1 
ATOM   1873 C  CA  . PHE A 1 230 ? -31.15819 -52.59604 14.96170  1.000 18.42528 ?  258 PHE A CA  1 
ATOM   1874 C  C   . PHE A 1 230 ? -31.80894 -51.22510 15.02092  1.000 17.87576 ?  258 PHE A C   1 
ATOM   1875 O  O   . PHE A 1 230 ? -32.99541 -51.10377 15.32540  1.000 20.52812 ?  258 PHE A O   1 
ATOM   1876 C  CB  . PHE A 1 230 ? -31.00667 -53.07178 13.49461  1.000 20.55224 ?  258 PHE A CB  1 
ATOM   1877 C  CG  . PHE A 1 230 ? -32.26337 -52.93683 12.68086  1.000 20.77025 ?  258 PHE A CG  1 
ATOM   1878 C  CD1 . PHE A 1 230 ? -33.26731 -53.89500 12.77479  1.000 21.11108 ?  258 PHE A CD1 1 
ATOM   1879 C  CD2 . PHE A 1 230 ? -32.44072 -51.85957 11.81533  1.000 21.15020 ?  258 PHE A CD2 1 
ATOM   1880 C  CE1 . PHE A 1 230 ? -34.44421 -53.77077 12.02707  1.000 18.18333 ?  258 PHE A CE1 1 
ATOM   1881 C  CE2 . PHE A 1 230 ? -33.61987 -51.72174 11.06783  1.000 21.44605 ?  258 PHE A CE2 1 
ATOM   1882 C  CZ  . PHE A 1 230 ? -34.61885 -52.68302 11.17460  1.000 19.86975 ?  258 PHE A CZ  1 
ATOM   1883 N  N   . GLY A 1 231 ? -31.02950 -50.18468 14.70848  1.000 18.61388 ?  259 GLY A N   1 
ATOM   1884 C  CA  . GLY A 1 231 ? -31.52124 -48.83102 14.82608  1.000 19.50890 ?  259 GLY A CA  1 
ATOM   1885 C  C   . GLY A 1 231 ? -30.99411 -47.92841 13.73009  1.000 23.54550 ?  259 GLY A C   1 
ATOM   1886 O  O   . GLY A 1 231 ? -30.02960 -48.25390 13.02289  1.000 20.77511 ?  259 GLY A O   1 
ATOM   1887 N  N   . VAL A 1 232 ? -31.66609 -46.78579 13.60681  1.000 19.85481 ?  260 VAL A N   1 
ATOM   1888 C  CA  . VAL A 1 232 ? -31.29949 -45.65247 12.76333  1.000 16.57387 ?  260 VAL A CA  1 
ATOM   1889 C  C   . VAL A 1 232 ? -31.03665 -44.47174 13.68493  1.000 19.92427 ?  260 VAL A C   1 
ATOM   1890 O  O   . VAL A 1 232 ? -31.17254 -44.58815 14.90880  1.000 21.48645 ?  260 VAL A O   1 
ATOM   1891 C  CB  . VAL A 1 232 ? -32.40968 -45.30878 11.74894  1.000 19.55324 ?  260 VAL A CB  1 
ATOM   1892 C  CG1 . VAL A 1 232 ? -32.68093 -46.48904 10.82384  1.000 20.16884 ?  260 VAL A CG1 1 
ATOM   1893 C  CG2 . VAL A 1 232 ? -33.70506 -44.89184 12.49634  1.000 19.73412 ?  260 VAL A CG2 1 
ATOM   1894 N  N   . ALA A 1 233 ? -30.63988 -43.33643 13.12040  1.000 19.64294 ?  261 ALA A N   1 
ATOM   1895 C  CA  . ALA A 1 233 ? -30.54235 -42.08926 13.86902  1.000 19.95440 ?  261 ALA A CA  1 
ATOM   1896 C  C   . ALA A 1 233 ? -31.66379 -41.14884 13.44845  1.000 17.75615 ?  261 ALA A C   1 
ATOM   1897 O  O   . ALA A 1 233 ? -31.99286 -41.03864 12.26650  1.000 20.08973 ?  261 ALA A O   1 
ATOM   1898 C  CB  . ALA A 1 233 ? -29.19067 -41.40437 13.65216  1.000 19.35317 ?  261 ALA A CB  1 
ATOM   1899 N  N   . ALA A 1 234 ? -32.22093 -40.42884 14.41038  1.000 17.57789 ?  262 ALA A N   1 
ATOM   1900 C  CA  . ALA A 1 234 ? -33.09452 -39.31800 14.06873  1.000 17.17111 ?  262 ALA A CA  1 
ATOM   1901 C  C   . ALA A 1 234 ? -32.25519 -38.16893 13.52719  1.000 19.36253 ?  262 ALA A C   1 
ATOM   1902 O  O   . ALA A 1 234 ? -31.19658 -37.85914 14.07063  1.000 22.15724 ?  262 ALA A O   1 
ATOM   1903 C  CB  . ALA A 1 234 ? -33.86328 -38.86514 15.31624  1.000 19.62712 ?  262 ALA A CB  1 
ATOM   1904 N  N   . THR A 1 235 ? -32.72210 -37.52659 12.45633  1.000 19.13550 ?  263 THR A N   1 
ATOM   1905 C  CA  . THR A 1 235 ? -31.99361 -36.39853 11.88033  1.000 18.94611 ?  263 THR A CA  1 
ATOM   1906 C  C   . THR A 1 235 ? -32.94882 -35.25030 11.59826  1.000 19.14978 ?  263 THR A C   1 
ATOM   1907 O  O   . THR A 1 235 ? -34.13784 -35.46209 11.35363  1.000 21.06670 ?  263 THR A O   1 
ATOM   1908 C  CB  . THR A 1 235 ? -31.24474 -36.79325 10.56715  1.000 18.65197 ?  263 THR A CB  1 
ATOM   1909 O  OG1 . THR A 1 235 ? -32.17801 -36.88808 9.48010   1.000 20.93872 ?  263 THR A OG1 1 
ATOM   1910 C  CG2 . THR A 1 235 ? -30.49926 -38.10440 10.74705  1.000 19.32114 ?  263 THR A CG2 1 
ATOM   1911 N  N   . LEU A 1 236 ? -32.43152 -34.02138 11.67041  1.000 19.03464 ?  264 LEU A N   1 
ATOM   1912 C  CA  . LEU A 1 236 ? -33.16921 -32.85096 11.21145  1.000 16.95585 ?  264 LEU A CA  1 
ATOM   1913 C  C   . LEU A 1 236 ? -32.72895 -32.55555 9.78483   1.000 20.27556 ?  264 LEU A C   1 
ATOM   1914 O  O   . LEU A 1 236 ? -31.52928 -32.36361 9.53706   1.000 21.37529 ?  264 LEU A O   1 
ATOM   1915 C  CB  . LEU A 1 236 ? -32.90136 -31.63631 12.10107  1.000 19.79153 ?  264 LEU A CB  1 
ATOM   1916 C  CG  . LEU A 1 236 ? -33.78239 -30.43585 11.77850  1.000 20.15622 ?  264 LEU A CG  1 
ATOM   1917 C  CD1 . LEU A 1 236 ? -35.21493 -30.74291 12.22084  1.000 20.19871 ?  264 LEU A CD1 1 
ATOM   1918 C  CD2 . LEU A 1 236 ? -33.27025 -29.16964 12.45853  1.000 21.84970 ?  264 LEU A CD2 1 
ATOM   1919 N  N   . VAL A 1 237 ? -33.68548 -32.50155 8.85977   1.000 20.46277 ?  265 VAL A N   1 
ATOM   1920 C  CA  . VAL A 1 237 ? -33.38793 -32.17246 7.46694   1.000 19.94891 ?  265 VAL A CA  1 
ATOM   1921 C  C   . VAL A 1 237 ? -34.17487 -30.93549 7.06569   1.000 25.35793 ?  265 VAL A C   1 
ATOM   1922 O  O   . VAL A 1 237 ? -35.14420 -30.54418 7.71307   1.000 22.56041 ?  265 VAL A O   1 
ATOM   1923 C  CB  . VAL A 1 237 ? -33.69019 -33.33216 6.49016   1.000 19.35112 ?  265 VAL A CB  1 
ATOM   1924 C  CG1 . VAL A 1 237 ? -32.81884 -34.53334 6.82335   1.000 20.32753 ?  265 VAL A CG1 1 
ATOM   1925 C  CG2 . VAL A 1 237 ? -35.17923 -33.72052 6.51629   1.000 20.90333 ?  265 VAL A CG2 1 
ATOM   1926 N  N   . THR A 1 238 ? -33.75627 -30.33360 5.95867   1.000 20.69974 ?  266 THR A N   1 
ATOM   1927 C  CA  . THR A 1 238 ? -34.41924 -29.15325 5.41342   1.000 19.45413 ?  266 THR A CA  1 
ATOM   1928 C  C   . THR A 1 238 ? -34.24061 -29.19470 3.89968   1.000 23.44804 ?  266 THR A C   1 
ATOM   1929 O  O   . THR A 1 238 ? -33.94863 -30.25009 3.32757   1.000 22.75692 ?  266 THR A O   1 
ATOM   1930 C  CB  . THR A 1 238 ? -33.85389 -27.86983 6.05780   1.000 22.58071 ?  266 THR A CB  1 
ATOM   1931 O  OG1 . THR A 1 238 ? -34.57274 -26.72036 5.59754   1.000 22.88942 ?  266 THR A OG1 1 
ATOM   1932 C  CG2 . THR A 1 238 ? -32.36741 -27.69459 5.74207   1.000 22.95093 ?  266 THR A CG2 1 
ATOM   1933 N  N   . THR A 1 239 ? -34.40593 -28.04844 3.24879   1.000 22.79625 ?  267 THR A N   1 
ATOM   1934 C  CA  . THR A 1 239 ? -34.20839 -27.94395 1.80939   1.000 22.93283 ?  267 THR A CA  1 
ATOM   1935 C  C   . THR A 1 239 ? -33.27589 -26.77928 1.51129   1.000 24.17852 ?  267 THR A C   1 
ATOM   1936 O  O   . THR A 1 239 ? -33.21906 -25.79721 2.25583   1.000 23.61117 ?  267 THR A O   1 
ATOM   1937 C  CB  . THR A 1 239 ? -35.54349 -27.77596 1.06617   1.000 26.73785 ?  267 THR A CB  1 
ATOM   1938 O  OG1 . THR A 1 239 ? -35.29979 -27.52570 -0.32915  1.000 25.31270 ?  267 THR A OG1 1 
ATOM   1939 C  CG2 . THR A 1 239 ? -36.36524 -26.65890 1.66578   1.000 24.26931 ?  267 THR A CG2 1 
ATOM   1940 N  N   . GLU A 1 240 ? -32.54156 -26.90915 0.40275   1.000 26.25735 ?  268 GLU A N   1 
ATOM   1941 C  CA  . GLU A 1 240 ? -31.72273 -25.80740 -0.09721  1.000 28.05983 ?  268 GLU A CA  1 
ATOM   1942 C  C   . GLU A 1 240 ? -32.53299 -24.52853 -0.27593  1.000 25.91683 ?  268 GLU A C   1 
ATOM   1943 O  O   . GLU A 1 240 ? -31.97461 -23.42795 -0.22198  1.000 29.35015 ?  268 GLU A O   1 
ATOM   1944 C  CB  . GLU A 1 240 ? -31.08371 -26.23955 -1.42108  1.000 30.43023 ?  268 GLU A CB  1 
ATOM   1945 C  CG  . GLU A 1 240 ? -30.78192 -25.13373 -2.40891  1.000 55.44493 ?  268 GLU A CG  1 
ATOM   1946 C  CD  . GLU A 1 240 ? -29.87685 -25.60878 -3.51802  1.000 68.72443 ?  268 GLU A CD  1 
ATOM   1947 O  OE1 . GLU A 1 240 ? -28.68299 -25.23708 -3.51391  1.000 72.98025 ?  268 GLU A OE1 1 
ATOM   1948 O  OE2 . GLU A 1 240 ? -30.36308 -26.36907 -4.38573  1.000 62.93056 ?  268 GLU A OE2 1 
ATOM   1949 N  N   . GLU A 1 241 ? -33.84836 -24.65139 -0.48436  1.000 27.15037 ?  269 GLU A N   1 
ATOM   1950 C  CA  . GLU A 1 241 ? -34.69445 -23.48055 -0.69278  1.000 27.08431 ?  269 GLU A CA  1 
ATOM   1951 C  C   . GLU A 1 241 ? -34.81818 -22.63168 0.56507   1.000 30.97627 ?  269 GLU A C   1 
ATOM   1952 O  O   . GLU A 1 241 ? -35.11642 -21.43654 0.46960   1.000 29.68887 ?  269 GLU A O   1 
ATOM   1953 C  CB  . GLU A 1 241 ? -36.08919 -23.89829 -1.16003  1.000 28.87136 ?  269 GLU A CB  1 
ATOM   1954 C  CG  . GLU A 1 241 ? -36.15418 -24.48386 -2.56390  1.000 36.89490 ?  269 GLU A CG  1 
ATOM   1955 C  CD  . GLU A 1 241 ? -37.58078 -24.81006 -2.98775  1.000 56.51611 ?  269 GLU A CD  1 
ATOM   1956 O  OE1 . GLU A 1 241 ? -38.49436 -24.73395 -2.13145  1.000 52.24832 ?  269 GLU A OE1 1 
ATOM   1957 O  OE2 . GLU A 1 241 ? -37.79090 -25.14532 -4.17647  1.000 53.78162 ?  269 GLU A OE2 1 
ATOM   1958 N  N   . VAL A 1 242 ? -34.63320 -23.22445 1.74673   1.000 24.17641 ?  270 VAL A N   1 
ATOM   1959 C  CA  . VAL A 1 242 ? -34.63262 -22.43199 2.97115   1.000 25.86290 ?  270 VAL A CA  1 
ATOM   1960 C  C   . VAL A 1 242 ? -33.35200 -21.61046 3.01984   1.000 27.78211 ?  270 VAL A C   1 
ATOM   1961 O  O   . VAL A 1 242 ? -32.27683 -22.07890 2.62004   1.000 26.33296 ?  270 VAL A O   1 
ATOM   1962 C  CB  . VAL A 1 242 ? -34.77045 -23.33679 4.20868   1.000 24.60238 ?  270 VAL A CB  1 
ATOM   1963 C  CG1 . VAL A 1 242 ? -34.57854 -22.51525 5.48899   1.000 23.24263 ?  270 VAL A CG1 1 
ATOM   1964 C  CG2 . VAL A 1 242 ? -36.12660 -24.01663 4.21699   1.000 27.06969 ?  270 VAL A CG2 1 
ATOM   1965 N  N   . SER A 1 243 ? -33.45532 -20.37015 3.49458   1.000 26.83651 ?  271 SER A N   1 
ATOM   1966 C  CA  . SER A 1 243 ? -32.30588 -19.48234 3.40827   1.000 30.50674 ?  271 SER A CA  1 
ATOM   1967 C  C   . SER A 1 243 ? -31.19891 -19.88382 4.37345   1.000 32.05578 ?  271 SER A C   1 
ATOM   1968 O  O   . SER A 1 243 ? -31.43445 -20.42437 5.46208   1.000 27.61911 ?  271 SER A O   1 
ATOM   1969 C  CB  . SER A 1 243 ? -32.70665 -18.04131 3.67288   1.000 33.60457 ?  271 SER A CB  1 
ATOM   1970 O  OG  . SER A 1 243 ? -32.73349 -17.77579 5.06177   1.000 35.52699 ?  271 SER A OG  1 
ATOM   1971 N  N   . GLU A 1 244 ? -29.96967 -19.57996 3.95829   1.000 27.14966 ?  272 GLU A N   1 
ATOM   1972 C  CA  . GLU A 1 244 ? -28.80718 -19.85626 4.78442   1.000 27.08940 ?  272 GLU A CA  1 
ATOM   1973 C  C   . GLU A 1 244 ? -28.92137 -19.20029 6.15675   1.000 28.86752 ?  272 GLU A C   1 
ATOM   1974 O  O   . GLU A 1 244 ? -28.55497 -19.80451 7.16958   1.000 27.97205 ?  272 GLU A O   1 
ATOM   1975 C  CB  . GLU A 1 244 ? -27.55936 -19.38804 4.03297   1.000 32.06229 ?  272 GLU A CB  1 
ATOM   1976 C  CG  . GLU A 1 244 ? -26.29165 -19.37257 4.83613   1.000 35.97641 ?  272 GLU A CG  1 
ATOM   1977 C  CD  . GLU A 1 244 ? -25.17202 -18.69621 4.08132   1.000 46.08177 ?  272 GLU A CD  1 
ATOM   1978 O  OE1 . GLU A 1 244 ? -24.78395 -19.23017 3.01632   1.000 43.34216 ?  272 GLU A OE1 1 
ATOM   1979 O  OE2 . GLU A 1 244 ? -24.69932 -17.63811 4.54475   1.000 45.16201 ?  272 GLU A OE2 1 
ATOM   1980 N  N   . ALA A 1 245 ? -29.43846 -17.97088 6.21686   1.000 26.05010 ?  273 ALA A N   1 
ATOM   1981 C  CA  . ALA A 1 245 ? -29.54918 -17.28604 7.50441   1.000 27.32474 ?  273 ALA A CA  1 
ATOM   1982 C  C   . ALA A 1 245 ? -30.48718 -18.02802 8.45214   1.000 24.69524 ?  273 ALA A C   1 
ATOM   1983 O  O   . ALA A 1 245 ? -30.22342 -18.11862 9.66195   1.000 28.03496 ?  273 ALA A O   1 
ATOM   1984 C  CB  . ALA A 1 245 ? -30.03434 -15.84925 7.29774   1.000 31.44701 ?  273 ALA A CB  1 
ATOM   1985 N  N   . VAL A 1 246 ? -31.59358 -18.55133 7.92879   1.000 24.83331 ?  274 VAL A N   1 
ATOM   1986 C  CA  . VAL A 1 246 ? -32.53617 -19.27269 8.78444   1.000 25.00634 ?  274 VAL A CA  1 
ATOM   1987 C  C   . VAL A 1 246 ? -31.89737 -20.54556 9.32829   1.000 25.47424 ?  274 VAL A C   1 
ATOM   1988 O  O   . VAL A 1 246 ? -31.96205 -20.82384 10.52998  1.000 23.39824 ?  274 VAL A O   1 
ATOM   1989 C  CB  . VAL A 1 246 ? -33.83819 -19.56845 8.02255   1.000 25.96925 ?  274 VAL A CB  1 
ATOM   1990 C  CG1 . VAL A 1 246 ? -34.65716 -20.63690 8.75528   1.000 24.35466 ?  274 VAL A CG1 1 
ATOM   1991 C  CG2 . VAL A 1 246 ? -34.63780 -18.29239 7.87673   1.000 27.36460 ?  274 VAL A CG2 1 
ATOM   1992 N  N   . VAL A 1 247 ? -31.26028 -21.33590 8.46001   1.000 23.70872 ?  275 VAL A N   1 
ATOM   1993 C  CA  . VAL A 1 247 ? -30.64943 -22.57442 8.93941   1.000 22.84088 ?  275 VAL A CA  1 
ATOM   1994 C  C   . VAL A 1 247 ? -29.48302 -22.27152 9.87251   1.000 24.61096 ?  275 VAL A C   1 
ATOM   1995 O  O   . VAL A 1 247 ? -29.28147 -22.95984 10.87848  1.000 22.59873 ?  275 VAL A O   1 
ATOM   1996 C  CB  . VAL A 1 247 ? -30.22529 -23.46141 7.75619   1.000 20.53662 ?  275 VAL A CB  1 
ATOM   1997 C  CG1 . VAL A 1 247 ? -29.62909 -24.77163 8.25999   1.000 22.84850 ?  275 VAL A CG1 1 
ATOM   1998 C  CG2 . VAL A 1 247 ? -31.42253 -23.72034 6.84414   1.000 22.75146 ?  275 VAL A CG2 1 
ATOM   1999 N  N   . TYR A 1 248 ? -28.71029 -21.22335 9.57294   1.000 24.23960 ?  276 TYR A N   1 
ATOM   2000 C  CA  . TYR A 1 248 ? -27.62461 -20.82060 10.45951  1.000 23.98590 ?  276 TYR A CA  1 
ATOM   2001 C  C   . TYR A 1 248 ? -28.14930 -20.51169 11.85841  1.000 23.27688 ?  276 TYR A C   1 
ATOM   2002 O  O   . TYR A 1 248 ? -27.62956 -21.01618 12.86186  1.000 22.26951 ?  276 TYR A O   1 
ATOM   2003 C  CB  . TYR A 1 248 ? -26.90126 -19.60530 9.86592   1.000 23.50778 ?  276 TYR A CB  1 
ATOM   2004 C  CG  . TYR A 1 248 ? -25.92018 -18.96433 10.81340  1.000 28.19711 ?  276 TYR A CG  1 
ATOM   2005 C  CD1 . TYR A 1 248 ? -24.64443 -19.49464 10.99323  1.000 28.09803 ?  276 TYR A CD1 1 
ATOM   2006 C  CD2 . TYR A 1 248 ? -26.26986 -17.82642 11.53711  1.000 31.41006 ?  276 TYR A CD2 1 
ATOM   2007 C  CE1 . TYR A 1 248 ? -23.74351 -18.90427 11.87140  1.000 29.37968 ?  276 TYR A CE1 1 
ATOM   2008 C  CE2 . TYR A 1 248 ? -25.38133 -17.23545 12.40774  1.000 30.88951 ?  276 TYR A CE2 1 
ATOM   2009 C  CZ  . TYR A 1 248 ? -24.12009 -17.77455 12.57276  1.000 36.26407 ?  276 TYR A CZ  1 
ATOM   2010 O  OH  . TYR A 1 248 ? -23.23504 -17.18545 13.44946  1.000 34.30055 ?  276 TYR A OH  1 
ATOM   2011 N  N   . ASN A 1 249 ? -29.21545 -19.71589 11.94329  1.000 24.99662 ?  277 ASN A N   1 
ATOM   2012 C  CA  . ASN A 1 249 ? -29.71186 -19.32360 13.26099  1.000 24.88064 ?  277 ASN A CA  1 
ATOM   2013 C  C   . ASN A 1 249 ? -30.31962 -20.50169 14.01203  1.000 23.56792 ?  277 ASN A C   1 
ATOM   2014 O  O   . ASN A 1 249 ? -30.19895 -20.58477 15.24343  1.000 23.65363 ?  277 ASN A O   1 
ATOM   2015 C  CB  . ASN A 1 249 ? -30.71619 -18.18585 13.11835  1.000 25.90024 ?  277 ASN A CB  1 
ATOM   2016 C  CG  . ASN A 1 249 ? -30.02869 -16.83315 12.98124  1.000 25.52410 ?  277 ASN A CG  1 
ATOM   2017 O  OD1 . ASN A 1 249 ? -29.24701 -16.44225 13.83826  1.000 31.78963 ?  277 ASN A OD1 1 
ATOM   2018 N  ND2 . ASN A 1 249 ? -30.30682 -16.13246 11.89379  1.000 30.13819 ?  277 ASN A ND2 1 
ATOM   2019 N  N   . LEU A 1 250 ? -30.98507 -21.41458 13.30321  1.000 23.01363 ?  278 LEU A N   1 
ATOM   2020 C  CA  . LEU A 1 250 ? -31.51342 -22.59662 13.98405  1.000 22.80044 ?  278 LEU A CA  1 
ATOM   2021 C  C   . LEU A 1 250 ? -30.38508 -23.48669 14.49114  1.000 22.18489 ?  278 LEU A C   1 
ATOM   2022 O  O   . LEU A 1 250 ? -30.42477 -23.97640 15.62861  1.000 21.93041 ?  278 LEU A O   1 
ATOM   2023 C  CB  . LEU A 1 250 ? -32.45023 -23.37688 13.05735  1.000 23.99045 ?  278 LEU A CB  1 
ATOM   2024 C  CG  . LEU A 1 250 ? -33.08192 -24.64336 13.66857  1.000 20.71514 ?  278 LEU A CG  1 
ATOM   2025 C  CD1 . LEU A 1 250 ? -34.47126 -24.90106 13.11066  1.000 23.87115 ?  278 LEU A CD1 1 
ATOM   2026 C  CD2 . LEU A 1 250 ? -32.20082 -25.88511 13.44739  1.000 21.04343 ?  278 LEU A CD2 1 
ATOM   2027 N  N   . THR A 1 251 ? -29.37526 -23.73857 13.64316  1.000 22.61858 ?  279 THR A N   1 
ATOM   2028 C  CA  . THR A 1 251 ? -28.25476 -24.57549 14.06298  1.000 23.81927 ?  279 THR A CA  1 
ATOM   2029 C  C   . THR A 1 251 ? -27.52194 -23.94908 15.24440  1.000 23.27155 ?  279 THR A C   1 
ATOM   2030 O  O   . THR A 1 251 ? -27.20176 -24.63056 16.22673  1.000 22.29071 ?  279 THR A O   1 
ATOM   2031 C  CB  . THR A 1 251 ? -27.29888 -24.79831 12.87902  1.000 22.09619 ?  279 THR A CB  1 
ATOM   2032 O  OG1 . THR A 1 251 ? -28.02342 -25.32997 11.76371  1.000 24.05468 ?  279 THR A OG1 1 
ATOM   2033 C  CG2 . THR A 1 251 ? -26.17659 -25.76704 13.24750  1.000 23.47072 ?  279 THR A CG2 1 
ATOM   2034 N  N   . LYS A 1 252 ? -27.26271 -22.64017 15.17250  1.000 24.11485 ?  280 LYS A N   1 
ATOM   2035 C  CA  . LYS A 1 252 ? -26.60491 -21.94449 16.27258  1.000 23.32255 ?  280 LYS A CA  1 
ATOM   2036 C  C   . LYS A 1 252 ? -27.43864 -22.00319 17.54774  1.000 23.82345 ?  280 LYS A C   1 
ATOM   2037 O  O   . LYS A 1 252 ? -26.89454 -22.14077 18.65013  1.000 24.01024 ?  280 LYS A O   1 
ATOM   2038 C  CB  . LYS A 1 252 ? -26.33866 -20.49913 15.85950  1.000 26.28130 ?  280 LYS A CB  1 
ATOM   2039 C  CG  . LYS A 1 252 ? -25.76842 -19.62064 16.94281  1.000 27.97959 ?  280 LYS A CG  1 
ATOM   2040 C  CD  . LYS A 1 252 ? -25.80890 -18.16243 16.47822  1.000 35.93876 ?  280 LYS A CD  1 
ATOM   2041 C  CE  . LYS A 1 252 ? -24.42002 -17.59045 16.29289  1.000 49.72588 ?  280 LYS A CE  1 
ATOM   2042 N  NZ  . LYS A 1 252 ? -24.47216 -16.13614 15.92005  1.000 49.33427 ?  280 LYS A NZ  1 
ATOM   2043 N  N   . ALA A 1 253 ? -28.76170 -21.90497 17.41809  1.000 25.22235 ?  281 ALA A N   1 
ATOM   2044 C  CA  . ALA A 1 253 ? -29.62822 -21.95466 18.59707  1.000 23.35308 ?  281 ALA A CA  1 
ATOM   2045 C  C   . ALA A 1 253 ? -29.44039 -23.25521 19.37493  1.000 24.02865 ?  281 ALA A C   1 
ATOM   2046 O  O   . ALA A 1 253 ? -29.35290 -23.24392 20.61147  1.000 24.81243 ?  281 ALA A O   1 
ATOM   2047 C  CB  . ALA A 1 253 ? -31.08881 -21.78833 18.17512  1.000 24.12732 ?  281 ALA A CB  1 
ATOM   2048 N  N   . VAL A 1 254 ? -29.35436 -24.38498 18.66662  1.000 20.96468 ?  282 VAL A N   1 
ATOM   2049 C  CA  . VAL A 1 254 ? -29.19572 -25.68107 19.32211  1.000 20.13398 ?  282 VAL A CA  1 
ATOM   2050 C  C   . VAL A 1 254 ? -27.77516 -25.84897 19.85419  1.000 23.71659 ?  282 VAL A C   1 
ATOM   2051 O  O   . VAL A 1 254 ? -27.56748 -26.22727 21.01469  1.000 24.56872 ?  282 VAL A O   1 
ATOM   2052 C  CB  . VAL A 1 254 ? -29.57744 -26.81463 18.34581  1.000 22.93500 ?  282 VAL A CB  1 
ATOM   2053 C  CG1 . VAL A 1 254 ? -29.19489 -28.17749 18.90559  1.000 26.10077 ?  282 VAL A CG1 1 
ATOM   2054 C  CG2 . VAL A 1 254 ? -31.07481 -26.75546 18.01747  1.000 21.14020 ?  282 VAL A CG2 1 
ATOM   2055 N  N   . PHE A 1 255 ? -26.76833 -25.57729 19.01747  1.000 23.93737 ?  283 PHE A N   1 
ATOM   2056 C  CA  . PHE A 1 255 ? -25.40061 -25.90804 19.42279  1.000 22.14245 ?  283 PHE A CA  1 
ATOM   2057 C  C   . PHE A 1 255 ? -24.83404 -24.92635 20.44903  1.000 23.85286 ?  283 PHE A C   1 
ATOM   2058 O  O   . PHE A 1 255 ? -24.09226 -25.33422 21.35363  1.000 27.07969 ?  283 PHE A O   1 
ATOM   2059 C  CB  . PHE A 1 255 ? -24.49953 -25.98875 18.18822  1.000 24.04510 ?  283 PHE A CB  1 
ATOM   2060 C  CG  . PHE A 1 255 ? -24.58328 -27.30867 17.47781  1.000 22.85041 ?  283 PHE A CG  1 
ATOM   2061 C  CD1 . PHE A 1 255 ? -25.69144 -27.62716 16.69500  1.000 21.25374 ?  283 PHE A CD1 1 
ATOM   2062 C  CD2 . PHE A 1 255 ? -23.57254 -28.24876 17.61564  1.000 23.27088 ?  283 PHE A CD2 1 
ATOM   2063 C  CE1 . PHE A 1 255 ? -25.77474 -28.84393 16.04645  1.000 23.74683 ?  283 PHE A CE1 1 
ATOM   2064 C  CE2 . PHE A 1 255 ? -23.64652 -29.47324 16.96670  1.000 27.66531 ?  283 PHE A CE2 1 
ATOM   2065 C  CZ  . PHE A 1 255 ? -24.74522 -29.77466 16.18451  1.000 25.42011 ?  283 PHE A CZ  1 
ATOM   2066 N  N   . GLU A 1 256 ? -25.17001 -23.63917 20.34363  1.000 25.96586 ?  284 GLU A N   1 
ATOM   2067 C  CA  . GLU A 1 256 ? -24.72557 -22.68843 21.36307  1.000 26.77620 ?  284 GLU A CA  1 
ATOM   2068 C  C   . GLU A 1 256 ? -25.48393 -22.84088 22.67760  1.000 32.08202 ?  284 GLU A C   1 
ATOM   2069 O  O   . GLU A 1 256 ? -25.05188 -22.28456 23.69252  1.000 29.34791 ?  284 GLU A O   1 
ATOM   2070 C  CB  . GLU A 1 256 ? -24.86157 -21.25569 20.84347  1.000 27.30385 ?  284 GLU A CB  1 
ATOM   2071 C  CG  . GLU A 1 256 ? -23.84747 -20.88160 19.74406  1.000 28.79811 ?  284 GLU A CG  1 
ATOM   2072 C  CD  . GLU A 1 256 ? -22.39496 -20.93310 20.21880  1.000 36.59927 ?  284 GLU A CD  1 
ATOM   2073 O  OE1 . GLU A 1 256 ? -22.09971 -20.32308 21.26721  1.000 38.54401 ?  284 GLU A OE1 1 
ATOM   2074 O  OE2 . GLU A 1 256 ? -21.54519 -21.57278 19.55207  1.000 34.97772 ?  284 GLU A OE2 1 
ATOM   2075 N  N   . ASN A 1 257 ? -26.59607 -23.56965 22.68356  1.000 26.14806 ?  285 ASN A N   1 
ATOM   2076 C  CA  . ASN A 1 257 ? -27.35060 -23.87905 23.89135  1.000 25.14058 ?  285 ASN A CA  1 
ATOM   2077 C  C   . ASN A 1 257 ? -27.38742 -25.38121 24.11869  1.000 29.68525 ?  285 ASN A C   1 
ATOM   2078 O  O   . ASN A 1 257 ? -28.38550 -25.93780 24.57495  1.000 26.83166 ?  285 ASN A O   1 
ATOM   2079 C  CB  . ASN A 1 257 ? -28.75623 -23.29873 23.80842  1.000 26.98000 ?  285 ASN A CB  1 
ATOM   2080 C  CG  . ASN A 1 257 ? -28.74788 -21.78832 23.76350  1.000 30.79859 ?  285 ASN A CG  1 
ATOM   2081 O  OD1 . ASN A 1 257 ? -28.60062 -21.13259 24.79301  1.000 33.01501 ?  285 ASN A OD1 1 
ATOM   2082 N  ND2 . ASN A 1 257 ? -28.89030 -21.22705 22.57150  1.000 24.38699 ?  285 ASN A ND2 1 
ATOM   2083 N  N   . PHE A 1 258 ? -26.26399 -26.04295 23.82522  1.000 27.36300 ?  286 PHE A N   1 
ATOM   2084 C  CA  . PHE A 1 258 ? -26.22763 -27.50040 23.80956  1.000 27.22721 ?  286 PHE A CA  1 
ATOM   2085 C  C   . PHE A 1 258 ? -26.51064 -28.08615 25.18475  1.000 26.14235 ?  286 PHE A C   1 
ATOM   2086 O  O   . PHE A 1 258 ? -27.22610 -29.08826 25.30073  1.000 29.08577 ?  286 PHE A O   1 
ATOM   2087 C  CB  . PHE A 1 258 ? -24.86786 -27.96093 23.29525  1.000 28.81343 ?  286 PHE A CB  1 
ATOM   2088 C  CG  . PHE A 1 258 ? -24.73832 -29.43904 23.13797  1.000 27.32871 ?  286 PHE A CG  1 
ATOM   2089 C  CD1 . PHE A 1 258 ? -25.36103 -30.09637 22.08850  1.000 30.41318 ?  286 PHE A CD1 1 
ATOM   2090 C  CD2 . PHE A 1 258 ? -23.98437 -30.17609 24.03831  1.000 30.55206 ?  286 PHE A CD2 1 
ATOM   2091 C  CE1 . PHE A 1 258 ? -25.23774 -31.46261 21.94270  1.000 27.19328 ?  286 PHE A CE1 1 
ATOM   2092 C  CE2 . PHE A 1 258 ? -23.85168 -31.55270 23.88791  1.000 32.11618 ?  286 PHE A CE2 1 
ATOM   2093 C  CZ  . PHE A 1 258 ? -24.48119 -32.18771 22.83774  1.000 28.94316 ?  286 PHE A CZ  1 
ATOM   2094 N  N   . ASP A 1 259 ? -25.95356 -27.48285 26.23706  1.000 28.80789 ?  287 ASP A N   1 
ATOM   2095 C  CA  . ASP A 1 259 ? -26.19234 -27.99348 27.58567  1.000 30.20300 ?  287 ASP A CA  1 
ATOM   2096 C  C   . ASP A 1 259 ? -27.65837 -27.88656 27.97917  1.000 28.86492 ?  287 ASP A C   1 
ATOM   2097 O  O   . ASP A 1 259 ? -28.14693 -28.70152 28.77130  1.000 31.59640 ?  287 ASP A O   1 
ATOM   2098 C  CB  . ASP A 1 259 ? -25.31711 -27.25087 28.59556  1.000 32.90782 ?  287 ASP A CB  1 
ATOM   2099 C  CG  . ASP A 1 259 ? -23.84396 -27.58601 28.43842  1.000 56.67961 ?  287 ASP A CG  1 
ATOM   2100 O  OD1 . ASP A 1 259 ? -22.99461 -26.73849 28.79267  1.000 56.31364 ?  287 ASP A OD1 1 
ATOM   2101 O  OD2 . ASP A 1 259 ? -23.53883 -28.69706 27.94405  1.000 50.43387 ?  287 ASP A OD2 1 
ATOM   2102 N  N   . THR A 1 260 ? -28.37418 -26.89750 27.44236  1.000 25.00209 ?  288 THR A N   1 
ATOM   2103 C  CA  . THR A 1 260 ? -29.81507 -26.81820 27.65570  1.000 22.92491 ?  288 THR A CA  1 
ATOM   2104 C  C   . THR A 1 260 ? -30.55220 -27.84042 26.80633  1.000 26.75830 ?  288 THR A C   1 
ATOM   2105 O  O   . THR A 1 260 ? -31.43775 -28.54771 27.29994  1.000 24.78181 ?  288 THR A O   1 
ATOM   2106 C  CB  . THR A 1 260 ? -30.32382 -25.41222 27.33585  1.000 24.16543 ?  288 THR A CB  1 
ATOM   2107 O  OG1 . THR A 1 260 ? -29.61496 -24.46252 28.14607  1.000 25.98725 ?  288 THR A OG1 1 
ATOM   2108 C  CG2 . THR A 1 260 ? -31.84079 -25.31255 27.58901  1.000 23.57616 ?  288 THR A CG2 1 
ATOM   2109 N  N   . PHE A 1 261 ? -30.19865 -27.91909 25.51724  1.000 24.56712 ?  289 PHE A N   1 
ATOM   2110 C  CA  . PHE A 1 261 ? -30.84330 -28.87408 24.62285  1.000 26.31601 ?  289 PHE A CA  1 
ATOM   2111 C  C   . PHE A 1 261 ? -30.82464 -30.28103 25.21384  1.000 24.90075 ?  289 PHE A C   1 
ATOM   2112 O  O   . PHE A 1 261 ? -31.84716 -30.97446 25.20822  1.000 24.72638 ?  289 PHE A O   1 
ATOM   2113 C  CB  . PHE A 1 261 ? -30.16223 -28.84519 23.24746  1.000 26.80167 ?  289 PHE A CB  1 
ATOM   2114 C  CG  . PHE A 1 261 ? -30.82856 -29.73220 22.21648  1.000 24.17086 ?  289 PHE A CG  1 
ATOM   2115 C  CD1 . PHE A 1 261 ? -32.08317 -29.41565 21.70590  1.000 23.04082 ?  289 PHE A CD1 1 
ATOM   2116 C  CD2 . PHE A 1 261 ? -30.20576 -30.89327 21.77889  1.000 27.50148 ?  289 PHE A CD2 1 
ATOM   2117 C  CE1 . PHE A 1 261 ? -32.69241 -30.23688 20.75303  1.000 25.40805 ?  289 PHE A CE1 1 
ATOM   2118 C  CE2 . PHE A 1 261 ? -30.80841 -31.71621 20.83351  1.000 27.83029 ?  289 PHE A CE2 1 
ATOM   2119 C  CZ  . PHE A 1 261 ? -32.05093 -31.39199 20.32563  1.000 26.17312 ?  289 PHE A CZ  1 
ATOM   2120 N  N   . THR A 1 262 ? -29.66886 -30.71908 25.73736  1.000 23.83494 ?  290 THR A N   1 
ATOM   2121 C  CA  . THR A 1 262 ? -29.56378 -32.10747 26.19284  1.000 23.13338 ?  290 THR A CA  1 
ATOM   2122 C  C   . THR A 1 262 ? -30.28892 -32.35656 27.50674  1.000 27.73435 ?  290 THR A C   1 
ATOM   2123 O  O   . THR A 1 262 ? -30.30537 -33.50163 27.97514  1.000 31.50767 ?  290 THR A O   1 
ATOM   2124 C  CB  . THR A 1 262 ? -28.10316 -32.55511 26.35662  1.000 30.16260 ?  290 THR A CB  1 
ATOM   2125 O  OG1 . THR A 1 262 ? -27.44271 -31.75088 27.34194  1.000 33.22781 ?  290 THR A OG1 1 
ATOM   2126 C  CG2 . THR A 1 262 ? -27.34872 -32.48562 25.02588  1.000 31.03768 ?  290 THR A CG2 1 
ATOM   2127 N  N   . ARG A 1 263 ? -30.86144 -31.31957 28.10796  1.000 25.80212 ?  291 ARG A N   1 
ATOM   2128 C  CA  . ARG A 1 263 ? -31.70039 -31.45383 29.28846  1.000 25.61542 ?  291 ARG A CA  1 
ATOM   2129 C  C   . ARG A 1 263 ? -33.18156 -31.44567 28.95963  1.000 30.46447 ?  291 ARG A C   1 
ATOM   2130 O  O   . ARG A 1 263 ? -34.00502 -31.58476 29.87202  1.000 31.56430 ?  291 ARG A O   1 
ATOM   2131 C  CB  . ARG A 1 263 ? -31.40996 -30.31314 30.27012  1.000 29.80212 ?  291 ARG A CB  1 
ATOM   2132 C  CG  . ARG A 1 263 ? -30.02358 -30.33199 30.85576  1.000 28.97579 ?  291 ARG A CG  1 
ATOM   2133 C  CD  . ARG A 1 263 ? -29.81841 -29.09569 31.70619  1.000 33.34853 ?  291 ARG A CD  1 
ATOM   2134 N  NE  . ARG A 1 263 ? -30.71100 -29.11509 32.85964  1.000 29.84566 ?  291 ARG A NE  1 
ATOM   2135 C  CZ  . ARG A 1 263 ? -30.84521 -28.11369 33.71901  1.000 31.43612 ?  291 ARG A CZ  1 
ATOM   2136 N  NH1 . ARG A 1 263 ? -30.13982 -27.00316 33.59634  1.000 31.22797 ?  291 ARG A NH1 1 
ATOM   2137 N  NH2 . ARG A 1 263 ? -31.71866 -28.22792 34.71814  1.000 34.62483 ?  291 ARG A NH2 1 
ATOM   2138 N  N   . LEU A 1 264 ? -33.54923 -31.28818 27.68761  1.000 27.26690 ?  292 LEU A N   1 
ATOM   2139 C  CA  . LEU A 1 264 ? -34.94651 -31.06382 27.34413  1.000 25.49012 ?  292 LEU A CA  1 
ATOM   2140 C  C   . LEU A 1 264 ? -35.73455 -32.34292 27.10125  1.000 37.76226 ?  292 LEU A C   1 
ATOM   2141 O  O   . LEU A 1 264 ? -36.96894 -32.31131 27.17776  1.000 34.58722 ?  292 LEU A O   1 
ATOM   2142 C  CB  . LEU A 1 264 ? -35.04685 -30.15611 26.11524  1.000 27.16058 ?  292 LEU A CB  1 
ATOM   2143 C  CG  . LEU A 1 264 ? -34.55313 -28.72947 26.39029  1.000 29.69087 ?  292 LEU A CG  1 
ATOM   2144 C  CD1 . LEU A 1 264 ? -34.72667 -27.82195 25.19078  1.000 25.71133 ?  292 LEU A CD1 1 
ATOM   2145 C  CD2 . LEU A 1 264 ? -35.28311 -28.14924 27.59471  1.000 30.14382 ?  292 LEU A CD2 1 
ATOM   2146 N  N   . HIS A 1 265 ? -35.06505 -33.45743 26.80466  1.000 25.39339 ?  293 HIS A N   1 
ATOM   2147 C  CA  . HIS A 1 265 ? -35.73102 -34.73176 26.62721  1.000 23.04398 ?  293 HIS A CA  1 
ATOM   2148 C  C   . HIS A 1 265 ? -34.70107 -35.76609 27.02748  1.000 22.41100 ?  293 HIS A C   1 
ATOM   2149 O  O   . HIS A 1 265 ? -33.52507 -35.63111 26.65945  1.000 25.56298 ?  293 HIS A O   1 
ATOM   2150 C  CB  . HIS A 1 265 ? -36.20949 -34.99389 25.19450  1.000 22.33507 ?  293 HIS A CB  1 
ATOM   2151 C  CG  . HIS A 1 265 ? -37.08369 -36.20800 25.06152  1.000 24.46793 ?  293 HIS A CG  1 
ATOM   2152 N  ND1 . HIS A 1 265 ? -36.57911 -37.48905 25.06883  1.000 25.86156 ?  293 HIS A ND1 1 
ATOM   2153 C  CD2 . HIS A 1 265 ? -38.42739 -36.33404 24.94545  1.000 23.54636 ?  293 HIS A CD2 1 
ATOM   2154 C  CE1 . HIS A 1 265 ? -37.57473 -38.35486 24.96581  1.000 25.06345 ?  293 HIS A CE1 1 
ATOM   2155 N  NE2 . HIS A 1 265 ? -38.70764 -37.67828 24.87640  1.000 22.40537 ?  293 HIS A NE2 1 
ATOM   2156 N  N   . PRO A 1 266 ? -35.09832 -36.79920 27.75828  1.000 25.21632 ?  294 PRO A N   1 
ATOM   2157 C  CA  . PRO A 1 266 ? -34.10757 -37.77175 28.21985  1.000 27.62303 ?  294 PRO A CA  1 
ATOM   2158 C  C   . PRO A 1 266 ? -33.42009 -38.52586 27.08498  1.000 31.51423 ?  294 PRO A C   1 
ATOM   2159 O  O   . PRO A 1 266 ? -32.29977 -39.01181 27.27621  1.000 32.03471 ?  294 PRO A O   1 
ATOM   2160 C  CB  . PRO A 1 266 ? -34.92447 -38.68611 29.14300  1.000 25.61659 ?  294 PRO A CB  1 
ATOM   2161 C  CG  . PRO A 1 266 ? -36.32983 -38.47581 28.76021  1.000 30.07945 ?  294 PRO A CG  1 
ATOM   2162 C  CD  . PRO A 1 266 ? -36.44744 -37.08027 28.26713  1.000 27.09767 ?  294 PRO A CD  1 
ATOM   2163 N  N   . ALA A 1 267 ? -34.00537 -38.56504 25.88290  1.000 24.45234 ?  295 ALA A N   1 
ATOM   2164 C  CA  . ALA A 1 267 ? -33.33212 -39.20168 24.75469  1.000 26.06401 ?  295 ALA A CA  1 
ATOM   2165 C  C   . ALA A 1 267 ? -32.09044 -38.43586 24.30591  1.000 28.95259 ?  295 ALA A C   1 
ATOM   2166 O  O   . ALA A 1 267 ? -31.25694 -39.00245 23.58802  1.000 29.80641 ?  295 ALA A O   1 
ATOM   2167 C  CB  . ALA A 1 267 ? -34.30268 -39.35508 23.57813  1.000 24.40540 ?  295 ALA A CB  1 
ATOM   2168 N  N   . PHE A 1 268 ? -31.93971 -37.17053 24.71189  1.000 24.86721 ?  296 PHE A N   1 
ATOM   2169 C  CA  . PHE A 1 268 ? -30.81579 -36.34169 24.28127  1.000 21.26477 ?  296 PHE A CA  1 
ATOM   2170 C  C   . PHE A 1 268 ? -29.63476 -36.36816 25.24953  1.000 23.08694 ?  296 PHE A C   1 
ATOM   2171 O  O   . PHE A 1 268 ? -28.65441 -35.65279 25.00976  1.000 25.28103 ?  296 PHE A O   1 
ATOM   2172 C  CB  . PHE A 1 268 ? -31.22913 -34.87495 24.12429  1.000 26.81089 ?  296 PHE A CB  1 
ATOM   2173 C  CG  . PHE A 1 268 ? -32.44262 -34.64686 23.26954  1.000 22.99676 ?  296 PHE A CG  1 
ATOM   2174 C  CD1 . PHE A 1 268 ? -32.80874 -35.54561 22.26961  1.000 25.21392 ?  296 PHE A CD1 1 
ATOM   2175 C  CD2 . PHE A 1 268 ? -33.22211 -33.51581 23.47943  1.000 24.08543 ?  296 PHE A CD2 1 
ATOM   2176 C  CE1 . PHE A 1 268 ? -33.94385 -35.30957 21.48906  1.000 22.86794 ?  296 PHE A CE1 1 
ATOM   2177 C  CE2 . PHE A 1 268 ? -34.35182 -33.27647 22.70942  1.000 24.57704 ?  296 PHE A CE2 1 
ATOM   2178 C  CZ  . PHE A 1 268 ? -34.71188 -34.17939 21.71159  1.000 25.97326 ?  296 PHE A CZ  1 
ATOM   2179 N  N   . ALA A 1 269 ? -29.71321 -37.15342 26.32681  1.000 26.68251 ?  297 ALA A N   1 
ATOM   2180 C  CA  . ALA A 1 269 ? -28.76977 -36.98663 27.43504  1.000 30.51108 ?  297 ALA A CA  1 
ATOM   2181 C  C   . ALA A 1 269 ? -27.32759 -37.23688 27.01123  1.000 34.08405 ?  297 ALA A C   1 
ATOM   2182 O  O   . ALA A 1 269 ? -26.40380 -36.64459 27.57913  1.000 33.58405 ?  297 ALA A O   1 
ATOM   2183 C  CB  . ALA A 1 269 ? -29.13640 -37.91867 28.58458  1.000 32.42581 ?  297 ALA A CB  1 
ATOM   2184 N  N   . ASN A 1 270 ? -27.11268 -38.10074 26.02152  1.000 27.25648 ?  298 ASN A N   1 
ATOM   2185 C  CA  . ASN A 1 270 ? -25.77103 -38.54462 25.66086  1.000 26.52660 ?  298 ASN A CA  1 
ATOM   2186 C  C   . ASN A 1 270 ? -25.33661 -38.08565 24.27404  1.000 28.54969 ?  298 ASN A C   1 
ATOM   2187 O  O   . ASN A 1 270 ? -24.36241 -38.62335 23.73061  1.000 27.89502 ?  298 ASN A O   1 
ATOM   2188 C  CB  . ASN A 1 270 ? -25.69453 -40.06230 25.76519  1.000 29.02533 ?  298 ASN A CB  1 
ATOM   2189 C  CG  . ASN A 1 270 ? -25.79105 -40.53785 27.19577  1.000 36.57129 ?  298 ASN A CG  1 
ATOM   2190 O  OD1 . ASN A 1 270 ? -24.98061 -40.15875 28.03428  1.000 31.64067 ?  298 ASN A OD1 1 
ATOM   2191 N  ND2 . ASN A 1 270 ? -26.81442 -41.33059 27.49323  1.000 35.15781 ?  298 ASN A ND2 1 
ATOM   2192 N  N   . LEU A 1 271 ? -26.01354 -37.09325 23.69698  1.000 23.20286 ?  299 LEU A N   1 
ATOM   2193 C  CA  . LEU A 1 271 ? -25.58221 -36.56781 22.40482  1.000 23.69154 ?  299 LEU A CA  1 
ATOM   2194 C  C   . LEU A 1 271 ? -24.20530 -35.92496 22.52180  1.000 25.52953 ?  299 LEU A C   1 
ATOM   2195 O  O   . LEU A 1 271 ? -23.78276 -35.47570 23.58995  1.000 26.99446 ?  299 LEU A O   1 
ATOM   2196 C  CB  . LEU A 1 271 ? -26.57686 -35.54118 21.86422  1.000 22.04493 ?  299 LEU A CB  1 
ATOM   2197 C  CG  . LEU A 1 271 ? -28.00557 -36.04800 21.64430  1.000 24.95699 ?  299 LEU A CG  1 
ATOM   2198 C  CD1 . LEU A 1 271 ? -28.89333 -34.91459 21.13762  1.000 29.69911 ?  299 LEU A CD1 1 
ATOM   2199 C  CD2 . LEU A 1 271 ? -28.02748 -37.22546 20.68804  1.000 30.52984 ?  299 LEU A CD2 1 
ATOM   2200 N  N   . LYS A 1 272 ? -23.51303 -35.88391 21.38919  1.000 27.18517 ?  300 LYS A N   1 
ATOM   2201 C  CA  . LYS A 1 272 ? -22.16533 -35.34795 21.26595  1.000 27.09687 ?  300 LYS A CA  1 
ATOM   2202 C  C   . LYS A 1 272 ? -22.13176 -34.44063 20.04419  1.000 24.55401 ?  300 LYS A C   1 
ATOM   2203 O  O   . LYS A 1 272 ? -22.52009 -34.86576 18.95113  1.000 26.27365 ?  300 LYS A O   1 
ATOM   2204 C  CB  . LYS A 1 272 ? -21.16632 -36.50038 21.12537  1.000 30.31874 ?  300 LYS A CB  1 
ATOM   2205 C  CG  . LYS A 1 272 ? -19.79002 -36.24647 21.70382  1.000 50.57080 ?  300 LYS A CG  1 
ATOM   2206 C  CD  . LYS A 1 272 ? -18.83213 -37.35720 21.27236  1.000 55.33845 ?  300 LYS A CD  1 
ATOM   2207 C  CE  . LYS A 1 272 ? -17.39061 -37.06003 21.66016  1.000 63.81858 ?  300 LYS A CE  1 
ATOM   2208 N  NZ  . LYS A 1 272 ? -16.77289 -36.06441 20.74463  1.000 53.47837 ?  300 LYS A NZ  1 
ATOM   2209 N  N   . LYS A 1 273 ? -21.69105 -33.18975 20.22735  1.000 26.55563 ?  301 LYS A N   1 
ATOM   2210 C  CA  . LYS A 1 273 ? -21.71687 -32.22552 19.12615  1.000 23.69019 ?  301 LYS A CA  1 
ATOM   2211 C  C   . LYS A 1 273 ? -21.06097 -32.77497 17.86591  1.000 28.35340 ?  301 LYS A C   1 
ATOM   2212 O  O   . LYS A 1 273 ? -21.60671 -32.64058 16.76811  1.000 24.64496 ?  301 LYS A O   1 
ATOM   2213 C  CB  . LYS A 1 273 ? -21.03423 -30.92227 19.53438  1.000 27.64077 ?  301 LYS A CB  1 
ATOM   2214 C  CG  . LYS A 1 273 ? -21.82192 -30.08192 20.51987  1.000 27.56103 ?  301 LYS A CG  1 
ATOM   2215 C  CD  . LYS A 1 273 ? -21.15285 -28.73341 20.66849  1.000 31.02919 ?  301 LYS A CD  1 
ATOM   2216 C  CE  . LYS A 1 273 ? -21.79225 -27.90464 21.75285  1.000 30.85401 ?  301 LYS A CE  1 
ATOM   2217 N  NZ  . LYS A 1 273 ? -21.10612 -26.58126 21.87492  1.000 30.91944 ?  301 LYS A NZ  1 
ATOM   2218 N  N   . GLU A 1 274 ? -19.87774 -33.38528 18.00074  1.000 28.59207 ?  302 GLU A N   1 
ATOM   2219 C  CA  . GLU A 1 274 ? -19.16079 -33.86430 16.82065  1.000 25.69884 ?  302 GLU A CA  1 
ATOM   2220 C  C   . GLU A 1 274 ? -19.94822 -34.92583 16.07137  1.000 27.35597 ?  302 GLU A C   1 
ATOM   2221 O  O   . GLU A 1 274 ? -19.97289 -34.92675 14.83309  1.000 28.04371 ?  302 GLU A O   1 
ATOM   2222 C  CB  . GLU A 1 274 ? -17.77411 -34.38345 17.22064  1.000 32.44145 ?  302 GLU A CB  1 
ATOM   2223 C  CG  . GLU A 1 274 ? -16.88383 -33.32974 17.91160  1.000 40.28793 ?  302 GLU A CG  1 
ATOM   2224 C  CD  . GLU A 1 274 ? -17.18420 -33.09037 19.40066  1.000 63.59015 ?  302 GLU A CD  1 
ATOM   2225 O  OE1 . GLU A 1 274 ? -18.03886 -33.79021 19.99942  1.000 43.80287 ?  302 GLU A OE1 1 
ATOM   2226 O  OE2 . GLU A 1 274 ? -16.54748 -32.17761 19.97601  1.000 60.90228 ?  302 GLU A OE2 1 
ATOM   2227 N  N   . ASP A 1 275 ? -20.59680 -35.84072 16.80035  1.000 28.74240 ?  303 ASP A N   1 
ATOM   2228 C  CA  . ASP A 1 275 ? -21.39049 -36.88123 16.15321  1.000 23.58774 ?  303 ASP A CA  1 
ATOM   2229 C  C   . ASP A 1 275 ? -22.63924 -36.29805 15.50256  1.000 21.93812 ?  303 ASP A C   1 
ATOM   2230 O  O   . ASP A 1 275 ? -23.10368 -36.79864 14.47088  1.000 27.43149 ?  303 ASP A O   1 
ATOM   2231 C  CB  . ASP A 1 275 ? -21.78902 -37.94407 17.17724  1.000 29.06292 ?  303 ASP A CB  1 
ATOM   2232 C  CG  . ASP A 1 275 ? -20.59927 -38.69202 17.73658  1.000 39.05894 ?  303 ASP A CG  1 
ATOM   2233 O  OD1 . ASP A 1 275 ? -19.48722 -38.53604 17.19410  1.000 38.90876 ?  303 ASP A OD1 1 
ATOM   2234 O  OD2 . ASP A 1 275 ? -20.77712 -39.42145 18.73053  1.000 42.45843 ?  303 ASP A OD2 1 
ATOM   2235 N  N   . MET A 1 276 ? -23.17355 -35.22690 16.08197  1.000 22.26384 ?  304 MET A N   1 
ATOM   2236 C  CA  . MET A 1 276 ? -24.38920 -34.62617 15.55829  1.000 20.32154 ?  304 MET A CA  1 
ATOM   2237 C  C   . MET A 1 276 ? -24.14288 -34.04447 14.17038  1.000 22.42016 ?  304 MET A C   1 
ATOM   2238 O  O   . MET A 1 276 ? -25.06428 -33.93940 13.35416  1.000 21.84248 ?  304 MET A O   1 
ATOM   2239 C  CB  . MET A 1 276 ? -24.83021 -33.54494 16.53346  1.000 23.69259 ?  304 MET A CB  1 
ATOM   2240 C  CG  . MET A 1 276 ? -25.80877 -34.06109 17.56054  1.000 24.58335 ?  304 MET A CG  1 
ATOM   2241 S  SD  . MET A 1 276 ? -26.05630 -32.87207 18.87486  1.000 25.61554 ?  304 MET A SD  1 
ATOM   2242 C  CE  . MET A 1 276 ? -27.47639 -32.03148 18.17916  1.000 23.12999 ?  304 MET A CE  1 
ATOM   2243 N  N   . VAL A 1 277 ? -22.89542 -33.66543 13.87809  1.000 22.85464 ?  305 VAL A N   1 
ATOM   2244 C  CA  . VAL A 1 277 ? -22.59139 -33.11895 12.56192  1.000 22.33791 ?  305 VAL A CA  1 
ATOM   2245 C  C   . VAL A 1 277 ? -22.59078 -34.21961 11.50950  1.000 21.71269 ?  305 VAL A C   1 
ATOM   2246 O  O   . VAL A 1 277 ? -23.10656 -34.03422 10.39773  1.000 23.41078 ?  305 VAL A O   1 
ATOM   2247 C  CB  . VAL A 1 277 ? -21.24386 -32.36869 12.59097  1.000 22.80733 ?  305 VAL A CB  1 
ATOM   2248 C  CG1 . VAL A 1 277 ? -20.84660 -31.93219 11.18497  1.000 24.78590 ?  305 VAL A CG1 1 
ATOM   2249 C  CG2 . VAL A 1 277 ? -21.32937 -31.16813 13.53152  1.000 24.93750 ?  305 VAL A CG2 1 
ATOM   2250 N  N   . THR A 1 278 ? -22.00491 -35.37392 11.82767  1.000 25.01793 ?  306 THR A N   1 
ATOM   2251 C  CA  . THR A 1 278 ? -21.69538 -36.37637 10.81148  1.000 25.51918 ?  306 THR A CA  1 
ATOM   2252 C  C   . THR A 1 278 ? -22.50423 -37.65777 10.91249  1.000 21.98315 ?  306 THR A C   1 
ATOM   2253 O  O   . THR A 1 278 ? -22.87983 -38.21061 9.88076   1.000 25.99086 ?  306 THR A O   1 
ATOM   2254 C  CB  . THR A 1 278 ? -20.21158 -36.74898 10.86963  1.000 28.50157 ?  306 THR A CB  1 
ATOM   2255 O  OG1 . THR A 1 278 ? -19.88279 -37.14828 12.20436  1.000 27.25561 ?  306 THR A OG1 1 
ATOM   2256 C  CG2 . THR A 1 278 ? -19.35200 -35.56333 10.46348  1.000 33.76766 ?  306 THR A CG2 1 
ATOM   2257 N  N   . ALA A 1 279 ? -22.73774 -38.17550 12.11893  1.000 23.69629 ?  307 ALA A N   1 
ATOM   2258 C  CA  . ALA A 1 279 ? -23.35660 -39.49187 12.26271  1.000 23.78137 ?  307 ALA A CA  1 
ATOM   2259 C  C   . ALA A 1 279 ? -24.77609 -39.48093 11.70946  1.000 26.16575 ?  307 ALA A C   1 
ATOM   2260 O  O   . ALA A 1 279 ? -25.56132 -38.58185 12.01492  1.000 26.06581 ?  307 ALA A O   1 
ATOM   2261 C  CB  . ALA A 1 279 ? -23.37071 -39.90756 13.73658  1.000 28.06521 ?  307 ALA A CB  1 
ATOM   2262 N  N   . GLY A 1 280 ? -25.11421 -40.47931 10.89287  1.000 25.19221 ?  308 GLY A N   1 
ATOM   2263 C  CA  . GLY A 1 280 ? -26.45906 -40.54273 10.35102  1.000 24.14308 ?  308 GLY A CA  1 
ATOM   2264 C  C   . GLY A 1 280 ? -26.75948 -39.56503 9.23885   1.000 24.83512 ?  308 GLY A C   1 
ATOM   2265 O  O   . GLY A 1 280 ? -27.88115 -39.57714 8.71161   1.000 22.66056 ?  308 GLY A O   1 
ATOM   2266 N  N   . ASN A 1 281 ? -25.80215 -38.71967 8.85088   1.000 22.60427 ?  309 ASN A N   1 
ATOM   2267 C  CA  . ASN A 1 281 ? -26.01058 -37.74011 7.79548   1.000 20.81086 ?  309 ASN A CA  1 
ATOM   2268 C  C   . ASN A 1 281 ? -25.24130 -38.17559 6.55587   1.000 24.45778 ?  309 ASN A C   1 
ATOM   2269 O  O   . ASN A 1 281 ? -24.00674 -38.17504 6.55215   1.000 28.49353 ?  309 ASN A O   1 
ATOM   2270 C  CB  . ASN A 1 281 ? -25.59835 -36.34664 8.26126   1.000 20.80909 ?  309 ASN A CB  1 
ATOM   2271 C  CG  . ASN A 1 281 ? -26.47543 -35.86220 9.39476   1.000 22.86211 ?  309 ASN A CG  1 
ATOM   2272 O  OD1 . ASN A 1 281 ? -27.67284 -36.14779 9.41669   1.000 21.23895 ?  309 ASN A OD1 1 
ATOM   2273 N  ND2 . ASN A 1 281 ? -25.88840 -35.15695 10.34381  1.000 22.68578 ?  309 ASN A ND2 1 
ATOM   2274 N  N   . SER A 1 282 ? -25.97689 -38.53141 5.51125   1.000 21.67464 ?  310 SER A N   1 
ATOM   2275 C  CA  . SER A 1 282 ? -25.40902 -39.10154 4.29450   1.000 24.02625 ?  310 SER A CA  1 
ATOM   2276 C  C   . SER A 1 282 ? -25.61314 -38.21100 3.08511   1.000 26.69109 ?  310 SER A C   1 
ATOM   2277 O  O   . SER A 1 282 ? -25.20859 -38.59077 1.97623   1.000 29.14014 ?  310 SER A O   1 
ATOM   2278 C  CB  . SER A 1 282 ? -26.02784 -40.47737 4.02301   1.000 27.44290 ?  310 SER A CB  1 
ATOM   2279 O  OG  . SER A 1 282 ? -27.43151 -40.35882 3.85109   1.000 27.15148 ?  310 SER A OG  1 
ATOM   2280 N  N   . ILE A 1 283 ? -26.24773 -37.06018 3.25916   1.000 23.39088 ?  311 ILE A N   1 
ATOM   2281 C  CA  . ILE A 1 283 ? -26.55519 -36.13215 2.17508   1.000 23.62848 ?  311 ILE A CA  1 
ATOM   2282 C  C   . ILE A 1 283 ? -25.92353 -34.79579 2.54883   1.000 21.79714 ?  311 ILE A C   1 
ATOM   2283 O  O   . ILE A 1 283 ? -25.50697 -34.59904 3.70170   1.000 24.72639 ?  311 ILE A O   1 
ATOM   2284 C  CB  . ILE A 1 283 ? -28.07895 -36.05082 1.91160   1.000 21.97361 ?  311 ILE A CB  1 
ATOM   2285 C  CG1 . ILE A 1 283 ? -28.77561 -35.21787 3.00463   1.000 21.87227 ?  311 ILE A CG1 1 
ATOM   2286 C  CG2 . ILE A 1 283 ? -28.68306 -37.45193 1.78224   1.000 20.36167 ?  311 ILE A CG2 1 
ATOM   2287 C  CD1 . ILE A 1 283 ? -30.23241 -34.98581 2.71418   1.000 22.51943 ?  311 ILE A CD1 1 
ATOM   2288 N  N   . PRO A 1 284 ? -25.78286 -33.86551 1.60041   1.000 24.15512 ?  312 PRO A N   1 
ATOM   2289 C  CA  A PRO A 1 284 ? -25.06483 -32.61790 1.90469   0.969 26.00386 ?  312 PRO A CA  1 
ATOM   2290 C  CA  B PRO A 1 284 ? -25.06304 -32.62047 1.90806   0.031 26.01370 ?  312 PRO A CA  1 
ATOM   2291 C  C   . PRO A 1 284 ? -25.70285 -31.83195 3.04657   1.000 27.80900 ?  312 PRO A C   1 
ATOM   2292 O  O   . PRO A 1 284 ? -26.92626 -31.72533 3.14994   1.000 25.75963 ?  312 PRO A O   1 
ATOM   2293 C  CB  A PRO A 1 284 ? -25.13633 -31.83861 0.58587   0.969 27.34376 ?  312 PRO A CB  1 
ATOM   2294 C  CB  B PRO A 1 284 ? -25.11851 -31.84301 0.58635   0.031 27.13846 ?  312 PRO A CB  1 
ATOM   2295 C  CG  A PRO A 1 284 ? -25.30625 -32.87425 -0.45579  0.969 26.08296 ?  312 PRO A CG  1 
ATOM   2296 C  CG  B PRO A 1 284 ? -26.22792 -32.47213 -0.19270  0.031 26.98314 ?  312 PRO A CG  1 
ATOM   2297 C  CD  A PRO A 1 284 ? -26.16953 -33.93928 0.17905   0.969 26.19726 ?  312 PRO A CD  1 
ATOM   2298 C  CD  B PRO A 1 284 ? -26.17548 -33.91676 0.18143   0.031 26.10729 ?  312 PRO A CD  1 
ATOM   2299 N  N   . LEU A 1 285 ? -24.85299 -31.28466 3.91036   1.000 24.62271 ?  313 LEU A N   1 
ATOM   2300 C  CA  . LEU A 1 285 ? -25.32163 -30.35528 4.93210   1.000 20.91605 ?  313 LEU A CA  1 
ATOM   2301 C  C   . LEU A 1 285 ? -25.77747 -29.06008 4.27864   1.000 27.63827 ?  313 LEU A C   1 
ATOM   2302 O  O   . LEU A 1 285 ? -25.18132 -28.58906 3.30163   1.000 24.80866 ?  313 LEU A O   1 
ATOM   2303 C  CB  . LEU A 1 285 ? -24.21646 -30.05559 5.94157   1.000 22.22573 ?  313 LEU A CB  1 
ATOM   2304 C  CG  . LEU A 1 285 ? -23.76051 -31.15975 6.88743   1.000 26.71371 ?  313 LEU A CG  1 
ATOM   2305 C  CD1 . LEU A 1 285 ? -22.51250 -30.72170 7.63235   1.000 27.71685 ?  313 LEU A CD1 1 
ATOM   2306 C  CD2 . LEU A 1 285 ? -24.87597 -31.51538 7.87855   1.000 25.28468 ?  313 LEU A CD2 1 
ATOM   2307 N  N   . HIS A 1 286 ? -26.83068 -28.46985 4.82686   1.000 23.80379 ?  314 HIS A N   1 
ATOM   2308 C  CA  . HIS A 1 286 ? -27.25696 -27.16406 4.35480   1.000 24.86310 ?  314 HIS A CA  1 
ATOM   2309 C  C   . HIS A 1 286 ? -26.14133 -26.14287 4.56607   1.000 25.00025 ?  314 HIS A C   1 
ATOM   2310 O  O   . HIS A 1 286 ? -25.48669 -26.14193 5.61749   1.000 24.66773 ?  314 HIS A O   1 
ATOM   2311 C  CB  . HIS A 1 286 ? -28.51171 -26.70871 5.09996   1.000 23.53482 ?  314 HIS A CB  1 
ATOM   2312 C  CG  . HIS A 1 286 ? -29.20796 -25.54947 4.45744   1.000 23.53903 ?  314 HIS A CG  1 
ATOM   2313 N  ND1 . HIS A 1 286 ? -28.77574 -24.24639 4.59612   1.000 24.58939 ?  314 HIS A ND1 1 
ATOM   2314 C  CD2 . HIS A 1 286 ? -30.31117 -25.50010 3.67400   1.000 23.95590 ?  314 HIS A CD2 1 
ATOM   2315 C  CE1 . HIS A 1 286 ? -29.58609 -23.44607 3.92626   1.000 23.99549 ?  314 HIS A CE1 1 
ATOM   2316 N  NE2 . HIS A 1 286 ? -30.52836 -24.18162 3.36277   1.000 23.13657 ?  314 HIS A NE2 1 
ATOM   2317 N  N   . PRO A 1 287 ? -25.90169 -25.26000 3.59391   1.000 25.28446 ?  315 PRO A N   1 
ATOM   2318 C  CA  . PRO A 1 287 ? -24.84597 -24.24384 3.75769   1.000 28.58277 ?  315 PRO A CA  1 
ATOM   2319 C  C   . PRO A 1 287 ? -24.96575 -23.40651 5.02424   1.000 27.05206 ?  315 PRO A C   1 
ATOM   2320 O  O   . PRO A 1 287 ? -23.93700 -22.98167 5.56439   1.000 29.02538 ?  315 PRO A O   1 
ATOM   2321 C  CB  . PRO A 1 287 ? -25.00410 -23.38593 2.49188   1.000 29.84456 ?  315 PRO A CB  1 
ATOM   2322 C  CG  . PRO A 1 287 ? -25.56270 -24.34152 1.46953   1.000 31.98688 ?  315 PRO A CG  1 
ATOM   2323 C  CD  . PRO A 1 287 ? -26.50636 -25.23409 2.25110   1.000 27.49355 ?  315 PRO A CD  1 
ATOM   2324 N  N   . GLY A 1 288 ? -26.18116 -23.14833 5.52117   1.000 25.11296 ?  316 GLY A N   1 
ATOM   2325 C  CA  . GLY A 1 288 ? -26.30499 -22.38703 6.75739   1.000 27.23231 ?  316 GLY A CA  1 
ATOM   2326 C  C   . GLY A 1 288 ? -25.78949 -23.14558 7.96606   1.000 26.98103 ?  316 GLY A C   1 
ATOM   2327 O  O   . GLY A 1 288 ? -25.23312 -22.55490 8.89950   1.000 23.98651 ?  316 GLY A O   1 
ATOM   2328 N  N   . ALA A 1 289 ? -25.97246 -24.46851 7.97302   1.000 24.19836 ?  317 ALA A N   1 
ATOM   2329 C  CA  . ALA A 1 289 ? -25.40305 -25.27525 9.04249   1.000 23.99953 ?  317 ALA A CA  1 
ATOM   2330 C  C   . ALA A 1 289 ? -23.88484 -25.31488 8.93395   1.000 25.75497 ?  317 ALA A C   1 
ATOM   2331 O  O   . ALA A 1 289 ? -23.17857 -25.17280 9.93568   1.000 25.38090 ?  317 ALA A O   1 
ATOM   2332 C  CB  . ALA A 1 289 ? -25.98057 -26.69183 9.00158   1.000 24.16510 ?  317 ALA A CB  1 
ATOM   2333 N  N   . VAL A 1 290 ? -23.36809 -25.49642 7.71885   1.000 27.88936 ?  318 VAL A N   1 
ATOM   2334 C  CA  . VAL A 1 290 ? -21.91886 -25.50336 7.52691   1.000 25.61416 ?  318 VAL A CA  1 
ATOM   2335 C  C   . VAL A 1 290 ? -21.30760 -24.20509 8.03213   1.000 25.87600 ?  318 VAL A C   1 
ATOM   2336 O  O   . VAL A 1 290 ? -20.26248 -24.21051 8.69765   1.000 27.62177 ?  318 VAL A O   1 
ATOM   2337 C  CB  . VAL A 1 290 ? -21.58623 -25.74512 6.04465   1.000 28.65948 ?  318 VAL A CB  1 
ATOM   2338 C  CG1 . VAL A 1 290 ? -20.06908 -25.67685 5.83158   1.000 29.24168 ?  318 VAL A CG1 1 
ATOM   2339 C  CG2 . VAL A 1 290 ? -22.13148 -27.09322 5.59881   1.000 28.36605 ?  318 VAL A CG2 1 
ATOM   2340 N  N   . LYS A 1 291 ? -21.95364 -23.07504 7.73166   1.000 26.70248 ?  319 LYS A N   1 
ATOM   2341 C  CA  . LYS A 1 291 ? -21.45145 -21.78260 8.18452   1.000 29.29043 ?  319 LYS A CA  1 
ATOM   2342 C  C   . LYS A 1 291 ? -21.28602 -21.75509 9.69837   1.000 31.22335 ?  319 LYS A C   1 
ATOM   2343 O  O   . LYS A 1 291 ? -20.24740 -21.31815 10.21136  1.000 31.14584 ?  319 LYS A O   1 
ATOM   2344 C  CB  . LYS A 1 291 ? -22.37964 -20.66518 7.72077   1.000 29.26586 ?  319 LYS A CB  1 
ATOM   2345 C  CG  . LYS A 1 291 ? -22.05272 -19.31235 8.32521   1.000 30.28017 ?  319 LYS A CG  1 
ATOM   2346 C  CD  . LYS A 1 291 ? -23.01327 -18.24807 7.83516   1.000 33.20689 ?  319 LYS A CD  1 
ATOM   2347 C  CE  . LYS A 1 291 ? -22.48399 -16.85340 8.14341   1.000 44.50814 ?  319 LYS A CE  1 
ATOM   2348 N  NZ  . LYS A 1 291 ? -23.59333 -15.88121 8.33568   1.000 44.31637 ?  319 LYS A NZ  1 
ATOM   2349 N  N   . TYR A 1 292 ? -22.29991 -22.22026 10.43967  1.000 25.22381 ?  320 TYR A N   1 
ATOM   2350 C  CA  . TYR A 1 292 ? -22.14836 -22.26142 11.88707  1.000 25.77593 ?  320 TYR A CA  1 
ATOM   2351 C  C   . TYR A 1 292 ? -21.05032 -23.23547 12.29317  1.000 26.39600 ?  320 TYR A C   1 
ATOM   2352 O  O   . TYR A 1 292 ? -20.24422 -22.93403 13.17991  1.000 28.11426 ?  320 TYR A O   1 
ATOM   2353 C  CB  . TYR A 1 292 ? -23.46334 -22.63336 12.59731  1.000 24.09687 ?  320 TYR A CB  1 
ATOM   2354 C  CG  . TYR A 1 292 ? -23.16538 -22.87958 14.05235  1.000 26.19421 ?  320 TYR A CG  1 
ATOM   2355 C  CD1 . TYR A 1 292 ? -22.93019 -21.81275 14.91368  1.000 27.10208 ?  320 TYR A CD1 1 
ATOM   2356 C  CD2 . TYR A 1 292 ? -23.00529 -24.16927 14.54469  1.000 25.46997 ?  320 TYR A CD2 1 
ATOM   2357 C  CE1 . TYR A 1 292 ? -22.59289 -22.01609 16.23731  1.000 27.79585 ?  320 TYR A CE1 1 
ATOM   2358 C  CE2 . TYR A 1 292 ? -22.66203 -24.38260 15.85387  1.000 26.60068 ?  320 TYR A CE2 1 
ATOM   2359 C  CZ  . TYR A 1 292 ? -22.45044 -23.30604 16.70350  1.000 25.83729 ?  320 TYR A CZ  1 
ATOM   2360 O  OH  . TYR A 1 292 ? -22.10336 -23.53807 18.01296  1.000 28.68540 ?  320 TYR A OH  1 
ATOM   2361 N  N   . TYR A 1 293 ? -21.02255 -24.42894 11.68955  1.000 25.57808 ?  321 TYR A N   1 
ATOM   2362 C  CA  . TYR A 1 293 ? -20.05426 -25.43327 12.12856  1.000 23.02095 ?  321 TYR A CA  1 
ATOM   2363 C  C   . TYR A 1 293 ? -18.62054 -24.95880 11.91269  1.000 27.02193 ?  321 TYR A C   1 
ATOM   2364 O  O   . TYR A 1 293 ? -17.73752 -25.27035 12.71698  1.000 30.69523 ?  321 TYR A O   1 
ATOM   2365 C  CB  . TYR A 1 293 ? -20.27100 -26.76735 11.41065  1.000 26.71753 ?  321 TYR A CB  1 
ATOM   2366 C  CG  . TYR A 1 293 ? -21.59881 -27.43089 11.74581  1.000 23.07509 ?  321 TYR A CG  1 
ATOM   2367 C  CD1 . TYR A 1 293 ? -22.12722 -27.35209 13.03163  1.000 25.64312 ?  321 TYR A CD1 1 
ATOM   2368 C  CD2 . TYR A 1 293 ? -22.29237 -28.14833 10.78386  1.000 26.18589 ?  321 TYR A CD2 1 
ATOM   2369 C  CE1 . TYR A 1 293 ? -23.34752 -27.96007 13.34288  1.000 22.99438 ?  321 TYR A CE1 1 
ATOM   2370 C  CE2 . TYR A 1 293 ? -23.51036 -28.75706 11.07859  1.000 24.29412 ?  321 TYR A CE2 1 
ATOM   2371 C  CZ  . TYR A 1 293 ? -24.02477 -28.65558 12.35687  1.000 22.79333 ?  321 TYR A CZ  1 
ATOM   2372 O  OH  . TYR A 1 293 ? -25.23607 -29.26122 12.63057  1.000 24.13554 ?  321 TYR A OH  1 
ATOM   2373 N  N   . LYS A 1 294 ? -18.38316 -24.18205 10.86054  1.000 29.83545 ?  322 LYS A N   1 
ATOM   2374 C  CA  . LYS A 1 294 ? -17.04612 -23.63670 10.64274  1.000 32.18681 ?  322 LYS A CA  1 
ATOM   2375 C  C   . LYS A 1 294 ? -16.70398 -22.58436 11.69093  1.000 35.88062 ?  322 LYS A C   1 
ATOM   2376 O  O   . LYS A 1 294 ? -15.58072 -22.56199 12.20620  1.000 34.64022 ?  322 LYS A O   1 
ATOM   2377 C  CB  . LYS A 1 294 ? -16.95189 -23.06451 9.23016   1.000 29.22719 ?  322 LYS A CB  1 
ATOM   2378 C  CG  . LYS A 1 294 ? -16.84323 -24.12164 8.15003   1.000 37.06919 ?  322 LYS A CG  1 
ATOM   2379 C  CD  . LYS A 1 294 ? -16.70386 -23.47522 6.77447   1.000 39.66868 ?  322 LYS A CD  1 
ATOM   2380 C  CE  . LYS A 1 294 ? -16.33344 -24.49424 5.71567   1.000 43.60279 ?  322 LYS A CE  1 
ATOM   2381 N  NZ  . LYS A 1 294 ? -16.49535 -23.92518 4.34032   1.000 51.39414 ?  322 LYS A NZ  1 
ATOM   2382 N  N   . GLU A 1 295 ? -17.66352 -21.71860 12.03814  1.000 30.32960 ?  323 GLU A N   1 
ATOM   2383 C  CA  . GLU A 1 295 ? -17.44254 -20.75970 13.11798  1.000 31.36031 ?  323 GLU A CA  1 
ATOM   2384 C  C   . GLU A 1 295 ? -17.09417 -21.46167 14.42275  1.000 36.82112 ?  323 GLU A C   1 
ATOM   2385 O  O   . GLU A 1 295 ? -16.22311 -21.00279 15.16866  1.000 38.49614 ?  323 GLU A O   1 
ATOM   2386 C  CB  . GLU A 1 295 ? -18.68041 -19.88267 13.32017  1.000 36.13383 ?  323 GLU A CB  1 
ATOM   2387 C  CG  . GLU A 1 295 ? -18.99413 -18.95741 12.16687  1.000 32.28535 ?  323 GLU A CG  1 
ATOM   2388 C  CD  . GLU A 1 295 ? -20.18413 -18.06691 12.45789  1.000 37.85556 ?  323 GLU A CD  1 
ATOM   2389 O  OE1 . GLU A 1 295 ? -20.81646 -18.24747 13.52623  1.000 36.68544 ?  323 GLU A OE1 1 
ATOM   2390 O  OE2 . GLU A 1 295 ? -20.47666 -17.18217 11.62781  1.000 44.14883 ?  323 GLU A OE2 1 
ATOM   2391 N  N   . ALA A 1 296 ? -17.77432 -22.56796 14.72429  1.000 30.76439 ?  324 ALA A N   1 
ATOM   2392 C  CA  . ALA A 1 296 ? -17.61687 -23.25753 15.99774  1.000 29.47819 ?  324 ALA A CA  1 
ATOM   2393 C  C   . ALA A 1 296 ? -16.44015 -24.21935 16.01565  1.000 30.27581 ?  324 ALA A C   1 
ATOM   2394 O  O   . ALA A 1 296 ? -16.17718 -24.82377 17.06075  1.000 35.64489 ?  324 ALA A O   1 
ATOM   2395 C  CB  . ALA A 1 296 ? -18.90284 -24.01944 16.33939  1.000 32.48891 ?  324 ALA A CB  1 
ATOM   2396 N  N   . GLY A 1 297 ? -15.74450 -24.39135 14.89240  1.000 32.87945 ?  325 GLY A N   1 
ATOM   2397 C  CA  . GLY A 1 297 ? -14.63278 -25.31553 14.83278  1.000 34.01790 ?  325 GLY A CA  1 
ATOM   2398 C  C   . GLY A 1 297 ? -15.01959 -26.77024 14.70918  1.000 42.71222 ?  325 GLY A C   1 
ATOM   2399 O  O   . GLY A 1 297 ? -14.15940 -27.64111 14.88462  1.000 34.82193 ?  325 GLY A O   1 
ATOM   2400 N  N   . LEU A 1 298 ? -16.29066 -27.06402 14.42424  1.000 31.40975 ?  326 LEU A N   1 
ATOM   2401 C  CA  . LEU A 1 298 ? -16.72676 -28.44112 14.24211  1.000 33.16633 ?  326 LEU A CA  1 
ATOM   2402 C  C   . LEU A 1 298 ? -16.45020 -28.94587 12.83721  1.000 34.61736 ?  326 LEU A C   1 
ATOM   2403 O  O   . LEU A 1 298 ? -16.34925 -30.15883 12.63287  1.000 36.51977 ?  326 LEU A O   1 
ATOM   2404 C  CB  . LEU A 1 298 ? -18.22044 -28.55702 14.56838  1.000 31.31470 ?  326 LEU A CB  1 
ATOM   2405 C  CG  . LEU A 1 298 ? -18.50640 -28.39827 16.06939  1.000 28.13470 ?  326 LEU A CG  1 
ATOM   2406 C  CD1 . LEU A 1 298 ? -19.98235 -28.13729 16.31889  1.000 29.85023 ?  326 LEU A CD1 1 
ATOM   2407 C  CD2 . LEU A 1 298 ? -18.05061 -29.61171 16.85175  1.000 35.12042 ?  326 LEU A CD2 1 
ATOM   2408 N  N   . ILE A 1 299 ? -16.34277 -28.04368 11.86872  1.000 30.73279 ?  327 ILE A N   1 
ATOM   2409 C  CA  . ILE A 1 299 ? -15.86849 -28.35417 10.52852  1.000 31.56778 ?  327 ILE A CA  1 
ATOM   2410 C  C   . ILE A 1 299 ? -14.69328 -27.42888 10.26088  1.000 38.07733 ?  327 ILE A C   1 
ATOM   2411 O  O   . ILE A 1 299 ? -14.78314 -26.22042 10.51155  1.000 35.49727 ?  327 ILE A O   1 
ATOM   2412 C  CB  . ILE A 1 299 ? -16.97152 -28.16751 9.47326   1.000 31.28634 ?  327 ILE A CB  1 
ATOM   2413 C  CG1 . ILE A 1 299 ? -18.01434 -29.27836 9.58957   1.000 31.96951 ?  327 ILE A CG1 1 
ATOM   2414 C  CG2 . ILE A 1 299 ? -16.38506 -28.16873 8.06890   1.000 33.32086 ?  327 ILE A CG2 1 
ATOM   2415 C  CD1 . ILE A 1 299 ? -19.12527 -29.14614 8.56690   1.000 32.92411 ?  327 ILE A CD1 1 
ATOM   2416 N  N   . LYS A 1 300 ? -13.58307 -27.99379 9.80505   1.000 47.74932 ?  328 LYS A N   1 
ATOM   2417 C  CA  . LYS A 1 300 ? -12.39807 -27.17729 9.56609   1.000 55.37310 ?  328 LYS A CA  1 
ATOM   2418 C  C   . LYS A 1 300 ? -12.45446 -26.53590 8.18482   1.000 58.22705 ?  328 LYS A C   1 
ATOM   2419 O  O   . LYS A 1 300 ? -12.96412 -27.11979 7.22573   1.000 56.80924 ?  328 LYS A O   1 
ATOM   2420 C  CB  . LYS A 1 300 ? -11.12150 -28.00693 9.73611   1.000 50.10888 ?  328 LYS A CB  1 
ATOM   2421 C  CG  . LYS A 1 300 ? -10.90470 -28.52815 11.16577  1.000 58.59405 ?  328 LYS A CG  1 
ATOM   2422 C  CD  . LYS A 1 300 ? -10.67964 -27.37130 12.14583  1.000 68.91887 ?  328 LYS A CD  1 
ATOM   2423 C  CE  . LYS A 1 300 ? -10.19628 -27.84260 13.52142  1.000 67.19097 ?  328 LYS A CE  1 
ATOM   2424 N  NZ  . LYS A 1 300 ? -11.22667 -28.57883 14.30033  1.000 68.46657 ?  328 LYS A NZ  1 
ATOM   2425 O  OXT . LYS A 1 300 ? -12.00830 -25.40056 8.00561   1.000 60.43245 ?  328 LYS A OXT 1 
HETATM 2426 N  N   . GLU B 2 .   ? -39.10478 -42.55959 13.32475  1.000 17.78113 ?  401 GLU A N   1 
HETATM 2427 C  CA  . GLU B 2 .   ? -40.58124 -42.50377 13.36492  1.000 17.72648 ?  401 GLU A CA  1 
HETATM 2428 C  C   . GLU B 2 .   ? -41.10230 -42.16216 11.98190  1.000 20.94861 ?  401 GLU A C   1 
HETATM 2429 O  O   . GLU B 2 .   ? -42.30098 -42.42763 11.69191  1.000 20.29436 ?  401 GLU A O   1 
HETATM 2430 C  CB  . GLU B 2 .   ? -41.06022 -41.39111 14.30469  1.000 17.71486 ?  401 GLU A CB  1 
HETATM 2431 C  CG  . GLU B 2 .   ? -40.53787 -41.64942 15.71840  1.000 18.89730 ?  401 GLU A CG  1 
HETATM 2432 C  CD  . GLU B 2 .   ? -41.01552 -40.56798 16.70264  1.000 19.04687 ?  401 GLU A CD  1 
HETATM 2433 O  OE1 . GLU B 2 .   ? -40.27415 -40.21820 17.66050  1.000 19.00665 ?  401 GLU A OE1 1 
HETATM 2434 O  OE2 . GLU B 2 .   ? -42.13329 -40.00611 16.52661  1.000 20.42949 -1 401 GLU A OE2 1 
HETATM 2435 O  OXT . GLU B 2 .   ? -40.32624 -41.61449 11.15568  1.000 20.22022 -1 401 GLU A OXT 1 
HETATM 2436 NA NA  . NA  C 3 .   ? -24.74366 -51.23121 9.13986   1.000 20.95285 ?  402 NA  A NA  1 
HETATM 2437 NA NA  . NA  D 3 .   ? -22.12315 -39.00486 7.72267   1.000 32.69844 ?  403 NA  A NA  1 
HETATM 2438 NA NA  . NA  E 3 .   ? -42.06339 -48.29221 1.56042   1.000 49.11381 ?  404 NA  A NA  1 
HETATM 2439 NA NA  . NA  F 3 .   ? -22.55772 -38.93440 30.20764  1.000 68.11183 ?  405 NA  A NA  1 
HETATM 2440 NA NA  . NA  G 3 .   ? -24.87839 -32.53637 29.71824  1.000 48.18623 ?  406 NA  A NA  1 
HETATM 2441 O  O   . HOH H 4 .   ? -20.88600 -18.60584 15.69298  1.000 46.81292 ?  501 HOH A O   1 
HETATM 2442 O  O   . HOH H 4 .   ? -47.11591 -41.69687 19.48260  1.000 34.58443 ?  502 HOH A O   1 
HETATM 2443 O  O   . HOH H 4 .   ? -40.28885 -59.65401 31.21188  1.000 47.46364 ?  503 HOH A O   1 
HETATM 2444 O  O   . HOH H 4 .   ? -50.62715 -64.84681 19.30654  1.000 45.21029 ?  504 HOH A O   1 
HETATM 2445 O  O   . HOH H 4 .   ? -58.25089 -59.23598 16.18766  1.000 35.48766 ?  505 HOH A O   1 
HETATM 2446 O  O   . HOH H 4 .   ? -30.68603 -49.37885 1.06764   1.000 37.54230 ?  506 HOH A O   1 
HETATM 2447 O  O   . HOH H 4 .   ? -50.73026 -32.43990 13.27629  1.000 36.24158 ?  507 HOH A O   1 
HETATM 2448 O  O   . HOH H 4 .   ? -38.77389 -27.97141 -2.74814  1.000 39.83102 ?  508 HOH A O   1 
HETATM 2449 O  O   . HOH H 4 .   ? -50.33408 -58.21123 27.06900  1.000 32.24216 ?  509 HOH A O   1 
HETATM 2450 O  O   . HOH H 4 .   ? -28.47254 -61.91588 15.62879  1.000 33.73983 ?  510 HOH A O   1 
HETATM 2451 O  O   . HOH H 4 .   ? -38.61859 -9.76540  15.41409  1.000 45.56956 ?  511 HOH A O   1 
HETATM 2452 O  O   . HOH H 4 .   ? -35.33847 -13.86013 10.03943  1.000 43.75939 ?  512 HOH A O   1 
HETATM 2453 O  O   . HOH H 4 .   ? -42.49221 -54.85812 29.57087  1.000 32.47255 ?  513 HOH A O   1 
HETATM 2454 O  O   . HOH H 4 .   ? -28.57296 -48.65096 25.00264  1.000 49.40002 ?  514 HOH A O   1 
HETATM 2455 O  O   . HOH H 4 .   ? -45.35086 -44.52582 -1.35108  1.000 45.11954 ?  515 HOH A O   1 
HETATM 2456 O  O   . HOH H 4 .   ? -34.97096 -49.61810 1.38972   1.000 27.18734 ?  516 HOH A O   1 
HETATM 2457 O  O   . HOH H 4 .   ? -43.14214 -37.89895 17.86156  1.000 22.17462 ?  517 HOH A O   1 
HETATM 2458 O  O   . HOH H 4 .   ? -24.42768 -59.35355 4.11766   1.000 37.68540 ?  518 HOH A O   1 
HETATM 2459 O  O   . HOH H 4 .   ? -37.23903 -7.30048  17.16605  1.000 52.43184 ?  519 HOH A O   1 
HETATM 2460 O  O   . HOH H 4 .   ? -54.01202 -46.78045 6.13904   1.000 45.93043 ?  520 HOH A O   1 
HETATM 2461 O  O   . HOH H 4 .   ? -38.81369 -67.18908 18.60562  1.000 43.85572 ?  521 HOH A O   1 
HETATM 2462 O  O   . HOH H 4 .   ? -44.27299 -21.57835 18.25786  1.000 27.86371 ?  522 HOH A O   1 
HETATM 2463 O  O   . HOH H 4 .   ? -38.003   -60.534   36.060    1.000 43.89876 ?  523 HOH A O   1 
HETATM 2464 O  O   . HOH H 4 .   ? -36.64616 -42.27746 -8.44619  1.000 30.99728 ?  524 HOH A O   1 
HETATM 2465 O  O   . HOH H 4 .   ? -43.18032 -68.00819 14.88031  1.000 45.99168 ?  525 HOH A O   1 
HETATM 2466 O  O   . HOH H 4 .   ? -23.62830 -40.51732 22.04751  1.000 45.32497 ?  526 HOH A O   1 
HETATM 2467 O  O   . HOH H 4 .   ? -37.22258 -54.41847 19.60124  1.000 27.09573 ?  527 HOH A O   1 
HETATM 2468 O  O   . HOH H 4 .   ? -33.36369 -13.74094 24.22477  1.000 38.60156 ?  528 HOH A O   1 
HETATM 2469 O  O   . HOH H 4 .   ? -42.89085 -49.15810 31.69140  1.000 33.57904 ?  529 HOH A O   1 
HETATM 2470 O  O   . HOH H 4 .   ? -44.43186 -41.04554 15.73571  1.000 20.51087 ?  530 HOH A O   1 
HETATM 2471 O  O   . HOH H 4 .   ? -26.81920 -45.09986 20.31644  1.000 45.66715 ?  531 HOH A O   1 
HETATM 2472 O  O   . HOH H 4 .   ? -29.925   -51.162   32.916    1.000 26.26963 ?  532 HOH A O   1 
HETATM 2473 O  O   . HOH H 4 .   ? -58.18841 -56.91503 15.20672  1.000 36.05139 ?  533 HOH A O   1 
HETATM 2474 O  O   . HOH H 4 .   ? -52.89495 -45.46978 22.37716  1.000 29.40265 ?  534 HOH A O   1 
HETATM 2475 O  O   . HOH H 4 .   ? -44.22269 -45.20594 5.07307   1.000 25.39107 ?  535 HOH A O   1 
HETATM 2476 O  O   . HOH H 4 .   ? -24.30307 -50.08107 17.18214  1.000 40.56286 ?  536 HOH A O   1 
HETATM 2477 O  O   . HOH H 4 .   ? -29.45391 -13.35737 20.28169  1.000 49.62791 ?  537 HOH A O   1 
HETATM 2478 O  O   . HOH H 4 .   ? -43.88232 -14.60458 7.16298   1.000 38.81379 ?  538 HOH A O   1 
HETATM 2479 O  O   . HOH H 4 .   ? -28.64302 -39.41386 23.91019  1.000 28.59630 ?  539 HOH A O   1 
HETATM 2480 O  O   . HOH H 4 .   ? -51.47295 -61.55269 21.48064  1.000 34.34450 ?  540 HOH A O   1 
HETATM 2481 O  O   . HOH H 4 .   ? -44.29275 -42.68595 13.56437  1.000 21.84088 ?  541 HOH A O   1 
HETATM 2482 O  O   . HOH H 4 .   ? -21.80428 -22.16096 4.17579   1.000 35.16532 ?  542 HOH A O   1 
HETATM 2483 O  O   . HOH H 4 .   ? -31.14118 -13.61834 4.78095   1.000 49.43558 ?  543 HOH A O   1 
HETATM 2484 O  O   . HOH H 4 .   ? -38.65327 -52.54630 -0.87307  1.000 33.87569 ?  544 HOH A O   1 
HETATM 2485 O  O   . HOH H 4 .   ? -44.786   -13.771   19.053    1.000 43.47059 ?  545 HOH A O   1 
HETATM 2486 O  O   . HOH H 4 .   ? -40.114   -55.298   35.998    1.000 29.60073 ?  546 HOH A O   1 
HETATM 2487 O  O   . HOH H 4 .   ? -38.18293 -20.66749 5.45157   1.000 36.16072 ?  547 HOH A O   1 
HETATM 2488 O  O   . HOH H 4 .   ? -27.77642 -44.01791 11.10564  1.000 23.16231 ?  548 HOH A O   1 
HETATM 2489 O  O   . HOH H 4 .   ? -41.515   -14.831   25.183    1.000 41.87995 ?  549 HOH A O   1 
HETATM 2490 O  O   . HOH H 4 .   ? -37.64519 -41.11429 17.79910  1.000 17.08369 ?  550 HOH A O   1 
HETATM 2491 O  O   . HOH H 4 .   ? -54.24737 -44.11392 13.18822  1.000 32.88326 ?  551 HOH A O   1 
HETATM 2492 O  O   . HOH H 4 .   ? -31.71370 -35.37912 29.31699  1.000 35.44681 ?  552 HOH A O   1 
HETATM 2493 O  O   . HOH H 4 .   ? -43.71986 -22.58559 7.42148   1.000 36.73045 ?  553 HOH A O   1 
HETATM 2494 O  O   . HOH H 4 .   ? -28.06335 -26.26892 32.02655  1.000 43.45617 ?  554 HOH A O   1 
HETATM 2495 O  O   . HOH H 4 .   ? -46.25468 -43.88679 1.82615   1.000 41.34361 ?  555 HOH A O   1 
HETATM 2496 O  O   . HOH H 4 .   ? -37.43321 -35.66672 -9.03117  1.000 36.63656 ?  556 HOH A O   1 
HETATM 2497 O  O   . HOH H 4 .   ? -27.35014 -14.56365 14.31907  1.000 47.11248 ?  557 HOH A O   1 
HETATM 2498 O  O   . HOH H 4 .   ? -28.36108 -40.85002 6.35237   1.000 23.46278 ?  558 HOH A O   1 
HETATM 2499 O  O   . HOH H 4 .   ? -46.57834 -49.55484 13.85963  1.000 23.18654 ?  559 HOH A O   1 
HETATM 2500 O  O   . HOH H 4 .   ? -24.52250 -34.94330 26.14682  1.000 37.95599 ?  560 HOH A O   1 
HETATM 2501 O  O   . HOH H 4 .   ? -27.36695 -31.92751 -4.13824  1.000 38.25504 ?  561 HOH A O   1 
HETATM 2502 O  O   . HOH H 4 .   ? -38.83379 -50.02534 0.05780   1.000 36.58187 ?  562 HOH A O   1 
HETATM 2503 O  O   . HOH H 4 .   ? -33.16632 -43.39179 21.97690  1.000 23.60042 ?  563 HOH A O   1 
HETATM 2504 O  O   . HOH H 4 .   ? -32.430   -41.882   26.600    1.000 39.33293 ?  564 HOH A O   1 
HETATM 2505 O  O   . HOH H 4 .   ? -32.11740 -42.47636 -7.94771  1.000 41.51543 ?  565 HOH A O   1 
HETATM 2506 O  O   . HOH H 4 .   ? -13.23329 -24.25602 11.59494  1.000 45.03638 ?  566 HOH A O   1 
HETATM 2507 O  O   . HOH H 4 .   ? -26.78569 -30.78079 29.90612  1.000 40.01328 ?  567 HOH A O   1 
HETATM 2508 O  O   . HOH H 4 .   ? -25.17858 -43.33165 -2.73781  1.000 35.89506 ?  568 HOH A O   1 
HETATM 2509 O  O   . HOH H 4 .   ? -41.38264 -20.46001 5.89902   1.000 36.23877 ?  569 HOH A O   1 
HETATM 2510 O  O   . HOH H 4 .   ? -20.75864 -25.57875 19.24148  1.000 36.33680 ?  570 HOH A O   1 
HETATM 2511 O  O   . HOH H 4 .   ? -24.37387 -57.95853 10.67475  1.000 30.40866 ?  571 HOH A O   1 
HETATM 2512 O  O   . HOH H 4 .   ? -48.89230 -30.52015 22.71322  1.000 50.25137 ?  572 HOH A O   1 
HETATM 2513 O  O   . HOH H 4 .   ? -23.25353 -34.96179 5.22285   1.000 36.67200 ?  573 HOH A O   1 
HETATM 2514 O  O   . HOH H 4 .   ? -24.73296 -32.17734 27.44252  1.000 48.70518 ?  574 HOH A O   1 
HETATM 2515 O  O   . HOH H 4 .   ? -52.908   -69.471   13.369    1.000 39.84918 ?  575 HOH A O   1 
HETATM 2516 O  O   . HOH H 4 .   ? -37.75457 -38.31409 -2.85714  1.000 24.89051 ?  576 HOH A O   1 
HETATM 2517 O  O   . HOH H 4 .   ? -32.13331 -18.63757 19.01774  1.000 27.27533 ?  577 HOH A O   1 
HETATM 2518 O  O   . HOH H 4 .   ? -44.07393 -33.82117 -2.39474  1.000 31.93342 ?  578 HOH A O   1 
HETATM 2519 O  O   . HOH H 4 .   ? -49.86473 -45.35005 21.39748  1.000 25.79205 ?  579 HOH A O   1 
HETATM 2520 O  O   . HOH H 4 .   ? -39.62535 -13.59620 4.54914   1.000 38.73410 ?  580 HOH A O   1 
HETATM 2521 O  O   . HOH H 4 .   ? -47.07319 -42.44870 13.40436  1.000 23.15432 ?  581 HOH A O   1 
HETATM 2522 O  O   . HOH H 4 .   ? -40.10707 -30.42966 24.21700  1.000 31.95737 ?  582 HOH A O   1 
HETATM 2523 O  O   . HOH H 4 .   ? -31.54640 -16.17979 25.51909  1.000 39.74248 ?  583 HOH A O   1 
HETATM 2524 O  O   . HOH H 4 .   ? -26.32570 -40.00503 -4.58192  1.000 49.51996 ?  584 HOH A O   1 
HETATM 2525 O  O   . HOH H 4 .   ? -21.379   -53.637   7.416     1.000 24.22017 ?  585 HOH A O   1 
HETATM 2526 O  O   . HOH H 4 .   ? -53.44257 -44.97621 8.56641   1.000 41.71081 ?  586 HOH A O   1 
HETATM 2527 O  O   . HOH H 4 .   ? -26.27101 -34.59909 29.44759  1.000 38.52519 ?  587 HOH A O   1 
HETATM 2528 O  O   . HOH H 4 .   ? -30.09318 -57.35871 16.65092  1.000 28.51069 ?  588 HOH A O   1 
HETATM 2529 O  O   . HOH H 4 .   ? -38.55905 -29.31659 25.98058  1.000 36.13004 ?  589 HOH A O   1 
HETATM 2530 O  O   . HOH H 4 .   ? -52.25570 -41.82948 22.96166  1.000 33.60289 ?  590 HOH A O   1 
HETATM 2531 O  O   . HOH H 4 .   ? -38.22428 -62.68088 23.80587  1.000 37.35936 ?  591 HOH A O   1 
HETATM 2532 O  O   . HOH H 4 .   ? -48.27438 -39.89382 13.41060  1.000 26.84756 ?  592 HOH A O   1 
HETATM 2533 O  O   . HOH H 4 .   ? -47.35837 -65.92973 7.18823   1.000 45.51822 ?  593 HOH A O   1 
HETATM 2534 O  O   . HOH H 4 .   ? -32.84815 -52.32358 20.67157  1.000 21.40476 ?  594 HOH A O   1 
HETATM 2535 O  O   . HOH H 4 .   ? -55.809   -62.125   6.825     1.000 32.98414 ?  595 HOH A O   1 
HETATM 2536 O  O   . HOH H 4 .   ? -19.19065 -17.13153 9.15678   1.000 42.89940 ?  596 HOH A O   1 
HETATM 2537 O  O   . HOH H 4 .   ? -27.71878 -24.85380 30.15450  1.000 36.50057 ?  597 HOH A O   1 
HETATM 2538 O  O   . HOH H 4 .   ? -37.786   -53.486   34.038    1.000 31.02934 ?  598 HOH A O   1 
HETATM 2539 O  O   . HOH H 4 .   ? -27.40356 -41.03057 18.29491  1.000 37.79660 ?  599 HOH A O   1 
HETATM 2540 O  O   . HOH H 4 .   ? -27.13043 -62.75281 7.59247   1.000 36.80631 ?  600 HOH A O   1 
HETATM 2541 O  O   . HOH H 4 .   ? -26.25158 -38.02251 16.64092  1.000 25.24301 ?  601 HOH A O   1 
HETATM 2542 O  O   . HOH H 4 .   ? -18.34067 -19.81168 8.82194   1.000 35.99742 ?  602 HOH A O   1 
HETATM 2543 O  O   . HOH H 4 .   ? -39.83333 -36.69494 -2.01133  1.000 26.17226 ?  603 HOH A O   1 
HETATM 2544 O  O   . HOH H 4 .   ? -29.80814 -18.69474 17.27727  1.000 31.02579 ?  604 HOH A O   1 
HETATM 2545 O  O   . HOH H 4 .   ? -17.20905 -32.46267 11.28274  1.000 38.51777 ?  605 HOH A O   1 
HETATM 2546 O  O   . HOH H 4 .   ? -25.37259 -46.92622 11.40289  1.000 27.27700 ?  606 HOH A O   1 
HETATM 2547 O  O   . HOH H 4 .   ? -38.82350 -20.23392 23.64697  1.000 28.50388 ?  607 HOH A O   1 
HETATM 2548 O  O   . HOH H 4 .   ? -33.43496 -61.90636 11.96313  1.000 25.92146 ?  608 HOH A O   1 
HETATM 2549 O  O   . HOH H 4 .   ? -45.66525 -66.46357 15.36284  1.000 37.62085 ?  609 HOH A O   1 
HETATM 2550 O  O   . HOH H 4 .   ? -31.29855 -20.72881 0.21694   1.000 40.89763 ?  610 HOH A O   1 
HETATM 2551 O  O   . HOH H 4 .   ? -29.574   -52.697   0.948     1.000 46.64039 ?  611 HOH A O   1 
HETATM 2552 O  O   . HOH H 4 .   ? -45.40152 -67.61217 17.91293  1.000 40.66510 ?  612 HOH A O   1 
HETATM 2553 O  O   . HOH H 4 .   ? -33.89855 -14.82368 8.46507   1.000 47.52349 ?  613 HOH A O   1 
HETATM 2554 O  O   . HOH H 4 .   ? -39.76497 -49.01979 2.32431   1.000 30.51258 ?  614 HOH A O   1 
HETATM 2555 O  O   . HOH H 4 .   ? -21.99127 -47.21663 9.08699   1.000 45.93112 ?  615 HOH A O   1 
HETATM 2556 O  O   . HOH H 4 .   ? -22.85037 -15.52184 4.94884   1.000 54.03555 ?  616 HOH A O   1 
HETATM 2557 O  O   . HOH H 4 .   ? -56.51925 -58.75261 7.42689   1.000 32.39379 ?  617 HOH A O   1 
HETATM 2558 O  O   . HOH H 4 .   ? -22.14797 -34.32484 7.73996   1.000 29.59651 ?  618 HOH A O   1 
HETATM 2559 O  O   . HOH H 4 .   ? -54.38405 -56.72830 6.74612   1.000 33.93898 ?  619 HOH A O   1 
HETATM 2560 O  O   . HOH H 4 .   ? -40.05477 -41.68859 -10.23105 1.000 37.49834 ?  620 HOH A O   1 
HETATM 2561 O  O   . HOH H 4 .   ? -30.86389 -36.96930 -9.47274  1.000 48.66200 ?  621 HOH A O   1 
HETATM 2562 O  O   . HOH H 4 .   ? -56.52966 -47.41756 19.02825  1.000 31.37475 ?  622 HOH A O   1 
HETATM 2563 O  O   . HOH H 4 .   ? -48.03525 -68.39509 18.71488  1.000 41.08268 ?  623 HOH A O   1 
HETATM 2564 O  O   . HOH H 4 .   ? -28.88800 -16.14938 16.64743  1.000 42.71082 ?  624 HOH A O   1 
HETATM 2565 O  O   . HOH H 4 .   ? -40.49439 -48.53591 -4.48698  1.000 45.05006 ?  625 HOH A O   1 
HETATM 2566 O  O   . HOH H 4 .   ? -34.86335 -65.25275 12.50040  1.000 33.74364 ?  626 HOH A O   1 
HETATM 2567 O  O   . HOH H 4 .   ? -29.19623 -15.04711 23.40627  1.000 45.33391 ?  627 HOH A O   1 
HETATM 2568 O  O   . HOH H 4 .   ? -54.74011 -63.43446 27.92807  1.000 44.45838 ?  628 HOH A O   1 
HETATM 2569 O  O   . HOH H 4 .   ? -52.98361 -44.76713 25.03514  1.000 46.85418 ?  629 HOH A O   1 
HETATM 2570 O  O   . HOH H 4 .   ? -41.44986 -66.31804 7.83386   1.000 44.70051 ?  630 HOH A O   1 
HETATM 2571 O  O   . HOH H 4 .   ? -27.42406 -43.88251 16.04663  1.000 42.10460 ?  631 HOH A O   1 
HETATM 2572 O  O   . HOH H 4 .   ? -53.82527 -63.37344 16.05583  1.000 31.44276 ?  632 HOH A O   1 
HETATM 2573 O  O   . HOH H 4 .   ? -31.76611 -47.65853 24.10012  1.000 39.53435 ?  633 HOH A O   1 
HETATM 2574 O  O   . HOH H 4 .   ? -35.65770 -52.48172 20.63101  1.000 25.62175 ?  634 HOH A O   1 
HETATM 2575 O  O   . HOH H 4 .   ? -19.78050 -40.02754 12.15865  1.000 39.34091 ?  635 HOH A O   1 
HETATM 2576 O  O   . HOH H 4 .   ? -33.91233 -59.95467 25.30721  1.000 43.33300 ?  636 HOH A O   1 
HETATM 2577 O  O   . HOH H 4 .   ? -43.96319 -66.54879 12.38188  1.000 41.30816 ?  637 HOH A O   1 
HETATM 2578 O  O   . HOH H 4 .   ? -27.79258 -46.49977 12.52311  1.000 24.46003 ?  638 HOH A O   1 
HETATM 2579 O  O   . HOH H 4 .   ? -36.38820 -12.79558 21.91775  1.000 28.10031 ?  639 HOH A O   1 
HETATM 2580 O  O   . HOH H 4 .   ? -22.01867 -14.74950 11.37019  1.000 49.53803 ?  640 HOH A O   1 
HETATM 2581 O  O   . HOH H 4 .   ? -31.33429 -41.88472 23.30762  1.000 28.15181 ?  641 HOH A O   1 
HETATM 2582 O  O   . HOH H 4 .   ? -43.63001 -30.08773 20.67614  1.000 27.17436 ?  642 HOH A O   1 
HETATM 2583 O  O   . HOH H 4 .   ? -49.23616 -36.17570 8.50213   1.000 29.55561 ?  643 HOH A O   1 
HETATM 2584 O  O   . HOH H 4 .   ? -46.02990 -41.17515 -0.56307  1.000 48.15533 ?  644 HOH A O   1 
HETATM 2585 O  O   . HOH H 4 .   ? -33.99268 -55.67733 3.30093   1.000 31.73542 ?  645 HOH A O   1 
HETATM 2586 O  O   . HOH H 4 .   ? -45.59443 -23.43394 6.10321   1.000 45.30916 ?  646 HOH A O   1 
HETATM 2587 O  O   . HOH H 4 .   ? -36.25520 -58.27351 28.06984  1.000 43.39249 ?  647 HOH A O   1 
HETATM 2588 O  O   . HOH H 4 .   ? -22.61295 -24.81468 23.80849  1.000 40.42554 ?  648 HOH A O   1 
HETATM 2589 O  O   . HOH H 4 .   ? -41.84521 -25.07302 21.25798  1.000 31.98427 ?  649 HOH A O   1 
HETATM 2590 O  O   . HOH H 4 .   ? -50.04271 -67.82190 13.89683  1.000 39.80113 ?  650 HOH A O   1 
HETATM 2591 O  O   . HOH H 4 .   ? -34.15495 -33.80668 -7.49270  1.000 34.11888 ?  651 HOH A O   1 
HETATM 2592 O  O   . HOH H 4 .   ? -31.97074 -51.42415 2.77048   1.000 31.58803 ?  652 HOH A O   1 
HETATM 2593 O  O   . HOH H 4 .   ? -20.44545 -32.48081 22.78006  1.000 33.26513 ?  653 HOH A O   1 
HETATM 2594 O  O   . HOH H 4 .   ? -32.05752 -59.18358 23.30789  1.000 28.27159 ?  654 HOH A O   1 
HETATM 2595 O  O   . HOH H 4 .   ? -46.88757 -67.78591 13.30507  1.000 51.24601 ?  655 HOH A O   1 
HETATM 2596 O  O   . HOH H 4 .   ? -42.89306 -45.12042 -4.12433  1.000 39.13720 ?  656 HOH A O   1 
HETATM 2597 O  O   . HOH H 4 .   ? -29.26658 -42.13756 21.41376  1.000 33.19997 ?  657 HOH A O   1 
HETATM 2598 O  O   . HOH H 4 .   ? -52.83688 -59.02706 6.11169   1.000 40.67798 ?  658 HOH A O   1 
HETATM 2599 O  O   . HOH H 4 .   ? -30.99173 -60.10724 27.01633  1.000 38.35007 ?  659 HOH A O   1 
HETATM 2600 O  O   . HOH H 4 .   ? -12.54240 -31.15654 13.79201  1.000 58.39250 ?  660 HOH A O   1 
HETATM 2601 O  O   . HOH H 4 .   ? -25.12770 -53.83677 26.16237  1.000 49.53689 ?  661 HOH A O   1 
HETATM 2602 O  O   . HOH H 4 .   ? -33.20261 -48.95293 3.46475   1.000 26.67969 ?  662 HOH A O   1 
HETATM 2603 O  O   . HOH H 4 .   ? -31.10935 -54.46847 3.17620   1.000 44.95940 ?  663 HOH A O   1 
HETATM 2604 O  O   . HOH H 4 .   ? -53.301   -62.426   5.160     1.000 53.73456 ?  664 HOH A O   1 
HETATM 2605 O  O   . HOH H 4 .   ? -21.96286 -31.90631 3.70183   1.000 36.85771 ?  665 HOH A O   1 
HETATM 2606 O  O   . HOH H 4 .   ? -23.79895 -52.36057 14.02366  1.000 28.76676 ?  666 HOH A O   1 
HETATM 2607 O  O   . HOH H 4 .   ? -28.22738 -48.82260 21.15661  1.000 35.20803 ?  667 HOH A O   1 
HETATM 2608 O  O   . HOH H 4 .   ? -41.01266 -65.97053 3.43531   1.000 43.73457 ?  668 HOH A O   1 
HETATM 2609 O  O   . HOH H 4 .   ? -36.15870 -19.31922 4.15359   1.000 33.68581 ?  669 HOH A O   1 
HETATM 2610 O  O   . HOH H 4 .   ? -24.11797 -41.24691 1.16396   1.000 38.76426 ?  670 HOH A O   1 
HETATM 2611 O  O   . HOH H 4 .   ? -34.617   -53.889   0.815     1.000 41.88591 ?  671 HOH A O   1 
HETATM 2612 O  O   . HOH H 4 .   ? -27.98564 -65.52363 13.48396  1.000 42.12458 ?  672 HOH A O   1 
HETATM 2613 O  O   . HOH H 4 .   ? -38.76359 -66.10689 6.26228   1.000 39.10973 ?  673 HOH A O   1 
HETATM 2614 O  O   . HOH H 4 .   ? -39.15194 -60.53672 32.98681  1.000 50.29071 ?  674 HOH A O   1 
HETATM 2615 O  O   . HOH H 4 .   ? -49.59668 -58.98825 0.24546   1.000 44.11891 ?  675 HOH A O   1 
HETATM 2616 O  O   . HOH H 4 .   ? -27.074   -53.678   0.350     1.000 35.99619 ?  676 HOH A O   1 
HETATM 2617 O  O   . HOH H 4 .   ? -37.00458 -32.83575 -7.13877  1.000 46.47997 ?  677 HOH A O   1 
HETATM 2618 O  O   . HOH H 4 .   ? -23.90272 -49.29307 10.21584  1.000 31.20478 ?  678 HOH A O   1 
HETATM 2619 O  O   . HOH H 4 .   ? -29.50914 -16.13956 3.80287   1.000 33.11023 ?  679 HOH A O   1 
HETATM 2620 O  O   . HOH H 4 .   ? -36.08011 -63.69011 14.62419  1.000 28.30446 ?  680 HOH A O   1 
HETATM 2621 O  O   . HOH H 4 .   ? -36.01233 -66.61277 19.09448  1.000 49.01513 ?  681 HOH A O   1 
HETATM 2622 O  O   . HOH H 4 .   ? -26.39604 -40.14583 -1.63311  1.000 45.36050 ?  682 HOH A O   1 
HETATM 2623 O  O   . HOH H 4 .   ? -17.97277 -26.12105 19.14209  1.000 45.88804 ?  683 HOH A O   1 
HETATM 2624 O  O   . HOH H 4 .   ? -35.43883 -64.53822 21.28755  1.000 51.50965 ?  684 HOH A O   1 
HETATM 2625 O  O   . HOH H 4 .   ? -55.56792 -43.98564 21.88135  1.000 42.23477 ?  685 HOH A O   1 
HETATM 2626 O  O   . HOH H 4 .   ? -37.71166 -59.60225 30.58529  1.000 40.94499 ?  686 HOH A O   1 
HETATM 2627 O  O   . HOH H 4 .   ? -39.73505 -33.18611 26.21654  1.000 38.32726 ?  687 HOH A O   1 
HETATM 2628 O  O   . HOH H 4 .   ? -44.17688 -50.61064 1.31533   1.000 41.62536 ?  688 HOH A O   1 
HETATM 2629 O  O   . HOH H 4 .   ? -21.36049 -34.28838 25.02972  1.000 48.18003 ?  689 HOH A O   1 
HETATM 2630 O  O   . HOH H 4 .   ? -23.309   -30.811   30.145    1.000 53.26823 ?  690 HOH A O   1 
HETATM 2631 O  O   . HOH H 4 .   ? -46.31517 -38.24317 2.11965   1.000 39.62263 ?  691 HOH A O   1 
HETATM 2632 O  O   . HOH H 4 .   ? -24.74466 -37.68588 19.21937  1.000 32.22177 ?  692 HOH A O   1 
HETATM 2633 O  O   . HOH H 4 .   ? -24.10074 -25.01945 26.03240  1.000 44.61001 ?  693 HOH A O   1 
HETATM 2634 O  O   . HOH H 4 .   ? -53.14766 -57.70084 3.53887   1.000 55.85771 ?  694 HOH A O   1 
HETATM 2635 O  O   . HOH H 4 .   ? -53.19379 -47.07574 26.19711  1.000 39.91758 ?  695 HOH A O   1 
HETATM 2636 O  O   . HOH H 4 .   ? -32.33944 -14.09122 10.45549  1.000 51.17025 ?  696 HOH A O   1 
HETATM 2637 O  O   . HOH H 4 .   ? -30.17761 -56.50034 1.99292   1.000 38.36407 ?  697 HOH A O   1 
HETATM 2638 O  O   . HOH H 4 .   ? -21.34052 -39.60124 5.58809   1.000 36.93171 ?  698 HOH A O   1 
HETATM 2639 O  O   . HOH H 4 .   ? -57.72715 -46.53225 16.72163  1.000 47.44800 ?  699 HOH A O   1 
HETATM 2640 O  O   . HOH H 4 .   ? -22.49496 -51.63813 8.82399   1.000 28.78747 ?  700 HOH A O   1 
HETATM 2641 O  O   . HOH H 4 .   ? -43.22470 -36.21953 -3.36838  1.000 36.76541 ?  701 HOH A O   1 
HETATM 2642 O  O   . HOH H 4 .   ? -21.05667 -36.96919 7.28709   1.000 31.43574 ?  702 HOH A O   1 
HETATM 2643 O  O   . HOH H 4 .   ? -44.23135 -47.67917 3.77614   1.000 28.58926 ?  703 HOH A O   1 
HETATM 2644 O  O   . HOH H 4 .   ? -46.94836 -41.33528 2.35549   1.000 47.05225 ?  704 HOH A O   1 
HETATM 2645 O  O   . HOH H 4 .   ? -55.61701 -53.71523 7.49862   1.000 47.89125 ?  705 HOH A O   1 
HETATM 2646 O  O   . HOH H 4 .   ? -32.187   -27.194   37.844    1.000 32.93212 ?  706 HOH A O   1 
HETATM 2647 O  O   . HOH H 4 .   ? -46.39284 -60.66373 -3.67386  1.000 56.81167 ?  707 HOH A O   1 
HETATM 2648 O  O   . HOH H 4 .   ? -40.04707 -59.31105 28.71485  1.000 45.67314 ?  708 HOH A O   1 
HETATM 2649 O  O   . HOH H 4 .   ? -42.512   -59.571   32.827    1.000 44.96245 ?  709 HOH A O   1 
HETATM 2650 O  O   . HOH H 4 .   ? -27.84778 -61.83438 19.23662  1.000 54.01979 ?  710 HOH A O   1 
HETATM 2651 O  O   . HOH H 4 .   ? -26.42960 -24.09488 27.01579  1.000 42.56386 ?  711 HOH A O   1 
HETATM 2652 O  O   . HOH H 4 .   ? -28.61123 -23.28416 0.25812   1.000 44.16859 ?  712 HOH A O   1 
HETATM 2653 O  O   . HOH H 4 .   ? -23.00333 -36.77083 27.94296  1.000 49.51883 ?  713 HOH A O   1 
HETATM 2654 O  O   . HOH H 4 .   ? -47.81101 -28.01292 7.28250   1.000 43.46685 ?  714 HOH A O   1 
HETATM 2655 O  O   . HOH H 4 .   ? -35.08897 -31.29279 -6.17295  1.000 42.73114 ?  715 HOH A O   1 
HETATM 2656 O  O   . HOH H 4 .   ? -23.18806 -41.25796 8.07947   1.000 33.50732 ?  716 HOH A O   1 
HETATM 2657 O  O   . HOH H 4 .   ? -20.33848 -40.31369 8.70390   1.000 39.86379 ?  717 HOH A O   1 
HETATM 2658 O  O   . HOH H 4 .   ? -45.33721 -27.92970 20.13394  1.000 38.60252 ?  718 HOH A O   1 
HETATM 2659 O  O   . HOH H 4 .   ? -23.05850 -41.61513 17.01434  1.000 45.53067 ?  719 HOH A O   1 
HETATM 2660 O  O   . HOH H 4 .   ? -37.67200 -45.28926 -9.73025  1.000 39.12283 ?  720 HOH A O   1 
HETATM 2661 O  O   . HOH H 4 .   ? -46.72501 -29.27143 23.40561  1.000 53.42890 ?  721 HOH A O   1 
HETATM 2662 O  O   . HOH H 4 .   ? -25.97050 -42.26281 7.18359   1.000 29.96905 ?  722 HOH A O   1 
HETATM 2663 O  O   . HOH H 4 .   ? -27.65954 -46.35924 15.14120  1.000 29.68527 ?  723 HOH A O   1 
HETATM 2664 O  O   . HOH H 4 .   ? -15.68026 -19.63368 9.68996   1.000 48.92450 ?  724 HOH A O   1 
HETATM 2665 O  O   . HOH H 4 .   ? -23.40755 -60.05717 9.54887   1.000 39.66666 ?  725 HOH A O   1 
HETATM 2666 O  O   . HOH H 4 .   ? -25.06714 -28.04082 -4.55780  1.000 51.16599 ?  726 HOH A O   1 
HETATM 2667 O  O   . HOH H 4 .   ? -25.02721 -60.98730 6.91602   1.000 44.49531 ?  727 HOH A O   1 
HETATM 2668 O  O   . HOH H 4 .   ? -44.08960 -31.90265 -4.32738  1.000 38.27450 ?  728 HOH A O   1 
HETATM 2669 O  O   . HOH H 4 .   ? -30.52845 -12.14816 6.87204   1.000 53.88062 ?  729 HOH A O   1 
HETATM 2670 O  O   . HOH H 4 .   ? -27.18310 -40.72023 21.99831  1.000 34.05014 ?  730 HOH A O   1 
HETATM 2671 O  O   . HOH H 4 .   ? -50.71817 -39.34414 11.38503  1.000 46.55006 ?  731 HOH A O   1 
HETATM 2672 O  O   . HOH H 4 .   ? -56.60491 -47.75148 7.14441   1.000 54.83582 ?  732 HOH A O   1 
HETATM 2673 O  O   . HOH H 4 .   ? -46.64871 -34.46723 -1.85363  1.000 49.80876 ?  733 HOH A O   1 
HETATM 2674 O  O   . HOH H 4 .   ? -47.717   -22.465   7.912     1.000 44.13848 ?  734 HOH A O   1 
HETATM 2675 O  O   . HOH H 4 .   ? -20.35720 -29.91026 24.13227  1.000 46.77460 ?  735 HOH A O   1 
HETATM 2676 O  O   . HOH H 4 .   ? -32.86621 -30.42727 -7.61365  1.000 45.94199 ?  736 HOH A O   1 
HETATM 2677 O  O   . HOH H 4 .   ? -22.38019 -56.21250 11.06770  1.000 40.52786 ?  737 HOH A O   1 
HETATM 2678 O  O   . HOH H 4 .   ? -44.33398 -20.11054 5.84314   1.000 46.94379 ?  738 HOH A O   1 
HETATM 2679 O  O   . HOH H 4 .   ? -25.459   -42.758   -5.273    1.000 30.84602 ?  739 HOH A O   1 
HETATM 2680 O  O   . HOH H 4 .   ? -20.91709 -57.68994 13.07787  1.000 53.11541 ?  740 HOH A O   1 
HETATM 2681 O  O   . HOH H 4 .   ? -27.12991 -16.06531 24.97503  1.000 52.15841 ?  741 HOH A O   1 
HETATM 2682 O  O   . HOH H 4 .   ? -22.51751 -50.32603 12.36188  1.000 43.84634 ?  742 HOH A O   1 
HETATM 2683 O  O   . HOH H 4 .   ? -38.64515 -11.24437 6.01778   1.000 48.88041 ?  743 HOH A O   1 
HETATM 2684 O  O   . HOH H 4 .   ? -36.01387 -60.42428 26.10817  1.000 46.62318 ?  744 HOH A O   1 
HETATM 2685 O  O   . HOH H 4 .   ? -33.82923 -42.00712 -10.15121 1.000 46.68827 ?  745 HOH A O   1 
HETATM 2686 O  O   . HOH H 4 .   ? -32.95019 -34.80551 -9.44115  1.000 39.03268 ?  746 HOH A O   1 
HETATM 2687 O  O   . HOH H 4 .   ? -23.50376 -46.21686 13.06434  1.000 45.78561 ?  747 HOH A O   1 
HETATM 2688 O  O   . HOH H 4 .   ? -28.05523 -59.34077 16.88668  1.000 38.22463 ?  748 HOH A O   1 
HETATM 2689 O  O   . HOH H 4 .   ? -19.85513 -33.27706 6.85888   1.000 42.22295 ?  749 HOH A O   1 
HETATM 2690 O  O   . HOH H 4 .   ? -22.86262 -53.65461 18.55759  1.000 52.20454 ?  750 HOH A O   1 
HETATM 2691 O  O   . HOH H 4 .   ? -19.80053 -36.20468 4.74271   1.000 56.80646 ?  751 HOH A O   1 
HETATM 2692 O  O   . HOH H 4 .   ? -19.88759 -31.13247 4.94212   1.000 45.47543 ?  752 HOH A O   1 
HETATM 2693 O  O   . HOH H 4 .   ? -18.32163 -37.34781 7.30191   1.000 44.25067 ?  753 HOH A O   1 
HETATM 2694 O  O   . HOH H 4 .   ? -17.59634 -32.91237 8.38672   1.000 38.54213 ?  754 HOH A O   1 
HETATM 2695 O  O   . HOH H 4 .   ? -51.23828 -37.05897 24.46528  1.000 54.87798 ?  755 HOH A O   1 
HETATM 2696 O  O   . HOH H 4 .   ? -24.47839 -46.50692 15.63692  1.000 50.06345 ?  756 HOH A O   1 
HETATM 2697 O  O   . HOH H 4 .   ? -21.98343 -54.08314 12.96738  1.000 45.25829 ?  757 HOH A O   1 
HETATM 2698 O  O   . HOH H 4 .   ? -18.05964 -29.60490 4.95527   1.000 42.15573 ?  758 HOH A O   1 
# 
