data_8RZU
# 
_entry.id   8RZU 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8RZU         pdb_00008rzu 10.2210/pdb8rzu/pdb 
WWPDB D_1292136572 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-03-05 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8RZU 
_pdbx_database_status.recvd_initial_deposition_date   2024-02-13 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              fernando.rodrigues-lima@u-paris.fr 
_pdbx_contact_author.name_first         Fernando 
_pdbx_contact_author.name_last          Rodrigues-Lima 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-1081-4767 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Mechaly, A.E.'      1 ? 
'Michail, C.'        2 ? 
'Haouz, A.'          3 ? 
'Rodrigues-Lima, F.' 4 ? 
# 
loop_
_citation.abstract 
_citation.abstract_id_CAS 
_citation.book_id_ISBN 
_citation.book_publisher 
_citation.book_publisher_city 
_citation.book_title 
_citation.coordinate_linkage 
_citation.country 
_citation.database_id_Medline 
_citation.details 
_citation.id 
_citation.journal_abbrev 
_citation.journal_id_ASTM 
_citation.journal_id_CSD 
_citation.journal_id_ISSN 
_citation.journal_full 
_citation.journal_issue 
_citation.journal_volume 
_citation.language 
_citation.page_first 
_citation.page_last 
_citation.title 
_citation.year 
_citation.database_id_CSD 
_citation.pdbx_database_id_DOI 
_citation.pdbx_database_id_PubMed 
_citation.pdbx_database_id_patent 
_citation.unpublished_flag 
? ? ? ? ? ? ? ?  ? ? primary 'To Be Published'                                ?      0353 ?         ? ? ?  ? ?   ?   
'Structure of human SETD2 L1609P mutant in complex with SAM and H3K36M peptide'                              ?    ? ? ?        ? ? 
? ? ? ? ? ? ? DK ? ? 1       'Acta Crystallogr., Sect. D: Biol. Crystallogr.' ABCRE6 0766 0907-4449 ? ? 75 ? 861 877 
'Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix' 2019 ? 
10.1107/S2059798319011471 31588918 ? ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Mechaly, A.E.'      1  ?                   
primary 'Michail, C.'        2  ?                   
primary 'Haouz, A.'          3  ?                   
primary 'Rodrigues-Lima, F.' 4  ?                   
1       'Liebschner, D.'     5  0000-0003-3921-3209 
1       'Afonine, P.V.'      6  0000-0002-5052-991X 
1       'Baker, M.L.'        7  ?                   
1       'Bunkoczi, G.'       8  ?                   
1       'Chen, V.B.'         9  0000-0003-2492-979X 
1       'Croll, T.I.'        10 ?                   
1       'Hintze, B.'         11 0000-0002-4871-2096 
1       'Hung, L.W.'         12 0000-0001-6690-8458 
1       'Jain, S.'           13 ?                   
1       'McCoy, A.J.'        14 ?                   
1       'Moriarty, N.W.'     15 0000-0001-8857-9464 
1       'Oeffner, R.D.'      16 0000-0003-3107-2202 
1       'Poon, B.K.'         17 0000-0001-9633-6067 
1       'Prisant, M.G.'      18 ?                   
1       'Read, R.J.'         19 0000-0001-8273-0047 
1       'Richardson, J.S.'   20 0000-0002-3311-2944 
1       'Richardson, D.C.'   21 ?                   
1       'Sammito, M.D.'      22 0000-0002-8346-9247 
1       'Sobolev, O.V.'      23 0000-0002-0623-3214 
1       'Stockwell, D.H.'    24 ?                   
1       'Terwilliger, T.C.'  25 0000-0001-6384-0320 
1       'Urzhumtsev, A.G.'   26 ?                   
1       'Videau, L.L.'       27 ?                   
1       'Williams, C.J.'     28 ?                   
1       'Adams, P.D.'        29 0000-0001-9333-8219 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Histone-lysine N-methyltransferase SETD2' 34082.770 1  2.1.1.359,2.1.1.- L1609P ? ? 
2 polymer     syn 'Histone H3'                               1560.822  1  ?                 ?      ? ? 
3 non-polymer syn 'ZINC ION'                                 65.409    3  ?                 ?      ? ? 
4 non-polymer syn S-ADENOSYLMETHIONINE                       398.437   1  ?                 ?      ? ? 
5 water       nat water                                      18.015    42 ?                 ?      ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        
;HIF-1,Huntingtin yeast partner B,Huntingtin-interacting protein 1,HIP-1,Huntingtin-interacting protein B,Lysine N-methyltransferase 3A,Protein-lysine N-methyltransferase SETD2,SET domain-containing protein 2,hSET2,p231HBP
;
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;MHHHHHHSSGRENLYFQGETSVPPGSALVGPSCVMDDFRDPQRWKECAKQGKMPCYFDLIEENVYLTERKKNKSHRDIKR
MQCECTPLSKDERAQGEIACGEDCLNRLLMIECSSRCPNGDYCSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFV
LEYCGEVLDHKEFKARVKEYARNKNIHYYFMAPKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLV
PSGSELTFDYQFQRYGKEAQKCFCGSANCRGYLGGENRVSIRAAGGKMKKERSRK
;
;MHHHHHHSSGRENLYFQGETSVPPGSALVGPSCVMDDFRDPQRWKECAKQGKMPCYFDLIEENVYLTERKKNKSHRDIKR
MQCECTPLSKDERAQGEIACGEDCLNRLLMIECSSRCPNGDYCSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFV
LEYCGEVLDHKEFKARVKEYARNKNIHYYFMAPKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLV
PSGSELTFDYQFQRYGKEAQKCFCGSANCRGYLGGENRVSIRAAGGKMKKERSRK
;
A ? 
2 'polypeptide(L)' no no APSTGGVMKPHRYR APSTGGVMKPHRYR B ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 'ZINC ION'           ZN  
4 S-ADENOSYLMETHIONINE SAM 
5 water                HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   HIS n 
1 3   HIS n 
1 4   HIS n 
1 5   HIS n 
1 6   HIS n 
1 7   HIS n 
1 8   SER n 
1 9   SER n 
1 10  GLY n 
1 11  ARG n 
1 12  GLU n 
1 13  ASN n 
1 14  LEU n 
1 15  TYR n 
1 16  PHE n 
1 17  GLN n 
1 18  GLY n 
1 19  GLU n 
1 20  THR n 
1 21  SER n 
1 22  VAL n 
1 23  PRO n 
1 24  PRO n 
1 25  GLY n 
1 26  SER n 
1 27  ALA n 
1 28  LEU n 
1 29  VAL n 
1 30  GLY n 
1 31  PRO n 
1 32  SER n 
1 33  CYS n 
1 34  VAL n 
1 35  MET n 
1 36  ASP n 
1 37  ASP n 
1 38  PHE n 
1 39  ARG n 
1 40  ASP n 
1 41  PRO n 
1 42  GLN n 
1 43  ARG n 
1 44  TRP n 
1 45  LYS n 
1 46  GLU n 
1 47  CYS n 
1 48  ALA n 
1 49  LYS n 
1 50  GLN n 
1 51  GLY n 
1 52  LYS n 
1 53  MET n 
1 54  PRO n 
1 55  CYS n 
1 56  TYR n 
1 57  PHE n 
1 58  ASP n 
1 59  LEU n 
1 60  ILE n 
1 61  GLU n 
1 62  GLU n 
1 63  ASN n 
1 64  VAL n 
1 65  TYR n 
1 66  LEU n 
1 67  THR n 
1 68  GLU n 
1 69  ARG n 
1 70  LYS n 
1 71  LYS n 
1 72  ASN n 
1 73  LYS n 
1 74  SER n 
1 75  HIS n 
1 76  ARG n 
1 77  ASP n 
1 78  ILE n 
1 79  LYS n 
1 80  ARG n 
1 81  MET n 
1 82  GLN n 
1 83  CYS n 
1 84  GLU n 
1 85  CYS n 
1 86  THR n 
1 87  PRO n 
1 88  LEU n 
1 89  SER n 
1 90  LYS n 
1 91  ASP n 
1 92  GLU n 
1 93  ARG n 
1 94  ALA n 
1 95  GLN n 
1 96  GLY n 
1 97  GLU n 
1 98  ILE n 
1 99  ALA n 
1 100 CYS n 
1 101 GLY n 
1 102 GLU n 
1 103 ASP n 
1 104 CYS n 
1 105 LEU n 
1 106 ASN n 
1 107 ARG n 
1 108 LEU n 
1 109 LEU n 
1 110 MET n 
1 111 ILE n 
1 112 GLU n 
1 113 CYS n 
1 114 SER n 
1 115 SER n 
1 116 ARG n 
1 117 CYS n 
1 118 PRO n 
1 119 ASN n 
1 120 GLY n 
1 121 ASP n 
1 122 TYR n 
1 123 CYS n 
1 124 SER n 
1 125 ASN n 
1 126 ARG n 
1 127 ARG n 
1 128 PHE n 
1 129 GLN n 
1 130 ARG n 
1 131 LYS n 
1 132 GLN n 
1 133 HIS n 
1 134 ALA n 
1 135 ASP n 
1 136 VAL n 
1 137 GLU n 
1 138 VAL n 
1 139 ILE n 
1 140 LEU n 
1 141 THR n 
1 142 GLU n 
1 143 LYS n 
1 144 LYS n 
1 145 GLY n 
1 146 TRP n 
1 147 GLY n 
1 148 LEU n 
1 149 ARG n 
1 150 ALA n 
1 151 ALA n 
1 152 LYS n 
1 153 ASP n 
1 154 LEU n 
1 155 PRO n 
1 156 SER n 
1 157 ASN n 
1 158 THR n 
1 159 PHE n 
1 160 VAL n 
1 161 LEU n 
1 162 GLU n 
1 163 TYR n 
1 164 CYS n 
1 165 GLY n 
1 166 GLU n 
1 167 VAL n 
1 168 LEU n 
1 169 ASP n 
1 170 HIS n 
1 171 LYS n 
1 172 GLU n 
1 173 PHE n 
1 174 LYS n 
1 175 ALA n 
1 176 ARG n 
1 177 VAL n 
1 178 LYS n 
1 179 GLU n 
1 180 TYR n 
1 181 ALA n 
1 182 ARG n 
1 183 ASN n 
1 184 LYS n 
1 185 ASN n 
1 186 ILE n 
1 187 HIS n 
1 188 TYR n 
1 189 TYR n 
1 190 PHE n 
1 191 MET n 
1 192 ALA n 
1 193 PRO n 
1 194 LYS n 
1 195 ASN n 
1 196 ASP n 
1 197 GLU n 
1 198 ILE n 
1 199 ILE n 
1 200 ASP n 
1 201 ALA n 
1 202 THR n 
1 203 GLN n 
1 204 LYS n 
1 205 GLY n 
1 206 ASN n 
1 207 CYS n 
1 208 SER n 
1 209 ARG n 
1 210 PHE n 
1 211 MET n 
1 212 ASN n 
1 213 HIS n 
1 214 SER n 
1 215 CYS n 
1 216 GLU n 
1 217 PRO n 
1 218 ASN n 
1 219 CYS n 
1 220 GLU n 
1 221 THR n 
1 222 GLN n 
1 223 LYS n 
1 224 TRP n 
1 225 THR n 
1 226 VAL n 
1 227 ASN n 
1 228 GLY n 
1 229 GLN n 
1 230 LEU n 
1 231 ARG n 
1 232 VAL n 
1 233 GLY n 
1 234 PHE n 
1 235 PHE n 
1 236 THR n 
1 237 THR n 
1 238 LYS n 
1 239 LEU n 
1 240 VAL n 
1 241 PRO n 
1 242 SER n 
1 243 GLY n 
1 244 SER n 
1 245 GLU n 
1 246 LEU n 
1 247 THR n 
1 248 PHE n 
1 249 ASP n 
1 250 TYR n 
1 251 GLN n 
1 252 PHE n 
1 253 GLN n 
1 254 ARG n 
1 255 TYR n 
1 256 GLY n 
1 257 LYS n 
1 258 GLU n 
1 259 ALA n 
1 260 GLN n 
1 261 LYS n 
1 262 CYS n 
1 263 PHE n 
1 264 CYS n 
1 265 GLY n 
1 266 SER n 
1 267 ALA n 
1 268 ASN n 
1 269 CYS n 
1 270 ARG n 
1 271 GLY n 
1 272 TYR n 
1 273 LEU n 
1 274 GLY n 
1 275 GLY n 
1 276 GLU n 
1 277 ASN n 
1 278 ARG n 
1 279 VAL n 
1 280 SER n 
1 281 ILE n 
1 282 ARG n 
1 283 ALA n 
1 284 ALA n 
1 285 GLY n 
1 286 GLY n 
1 287 LYS n 
1 288 MET n 
1 289 LYS n 
1 290 LYS n 
1 291 GLU n 
1 292 ARG n 
1 293 SER n 
1 294 ARG n 
1 295 LYS n 
2 1   ALA n 
2 2   PRO n 
2 3   SER n 
2 4   THR n 
2 5   GLY n 
2 6   GLY n 
2 7   VAL n 
2 8   MET n 
2 9   LYS n 
2 10  PRO n 
2 11  HIS n 
2 12  ARG n 
2 13  TYR n 
2 14  ARG n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   295 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'SETD2, HIF1, HYPB, KIAA1732, KMT3A, SET2, HSPC069' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
_pdbx_entity_src_syn.entity_id              2 
_pdbx_entity_src_syn.pdbx_src_id            1 
_pdbx_entity_src_syn.pdbx_alt_source_flag   sample 
_pdbx_entity_src_syn.pdbx_beg_seq_num       1 
_pdbx_entity_src_syn.pdbx_end_seq_num       14 
_pdbx_entity_src_syn.organism_scientific    'Homo sapiens' 
_pdbx_entity_src_syn.organism_common_name   human 
_pdbx_entity_src_syn.ncbi_taxonomy_id       9606 
_pdbx_entity_src_syn.details                ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE              ? 'C3 H7 N O2'      89.093  
ARG 'L-peptide linking' y ARGININE             ? 'C6 H15 N4 O2 1'  175.209 
ASN 'L-peptide linking' y ASPARAGINE           ? 'C4 H8 N2 O3'     132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'      ? 'C4 H7 N O4'      133.103 
CYS 'L-peptide linking' y CYSTEINE             ? 'C3 H7 N O2 S'    121.158 
GLN 'L-peptide linking' y GLUTAMINE            ? 'C5 H10 N2 O3'    146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'      ? 'C5 H9 N O4'      147.129 
GLY 'peptide linking'   y GLYCINE              ? 'C2 H5 N O2'      75.067  
HIS 'L-peptide linking' y HISTIDINE            ? 'C6 H10 N3 O2 1'  156.162 
HOH non-polymer         . WATER                ? 'H2 O'            18.015  
ILE 'L-peptide linking' y ISOLEUCINE           ? 'C6 H13 N O2'     131.173 
LEU 'L-peptide linking' y LEUCINE              ? 'C6 H13 N O2'     131.173 
LYS 'L-peptide linking' y LYSINE               ? 'C6 H15 N2 O2 1'  147.195 
MET 'L-peptide linking' y METHIONINE           ? 'C5 H11 N O2 S'   149.211 
PHE 'L-peptide linking' y PHENYLALANINE        ? 'C9 H11 N O2'     165.189 
PRO 'L-peptide linking' y PROLINE              ? 'C5 H9 N O2'      115.130 
SAM non-polymer         . S-ADENOSYLMETHIONINE ? 'C15 H22 N6 O5 S' 398.437 
SER 'L-peptide linking' y SERINE               ? 'C3 H7 N O3'      105.093 
THR 'L-peptide linking' y THREONINE            ? 'C4 H9 N O3'      119.119 
TRP 'L-peptide linking' y TRYPTOPHAN           ? 'C11 H12 N2 O2'   204.225 
TYR 'L-peptide linking' y TYROSINE             ? 'C9 H11 N O3'     181.189 
VAL 'L-peptide linking' y VALINE               ? 'C5 H11 N O2'     117.146 
ZN  non-polymer         . 'ZINC ION'           ? 'Zn 2'            65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1417 ?    ?   ?   A . n 
A 1 2   HIS 2   1418 ?    ?   ?   A . n 
A 1 3   HIS 3   1419 ?    ?   ?   A . n 
A 1 4   HIS 4   1420 ?    ?   ?   A . n 
A 1 5   HIS 5   1421 ?    ?   ?   A . n 
A 1 6   HIS 6   1422 ?    ?   ?   A . n 
A 1 7   HIS 7   1423 ?    ?   ?   A . n 
A 1 8   SER 8   1424 ?    ?   ?   A . n 
A 1 9   SER 9   1425 ?    ?   ?   A . n 
A 1 10  GLY 10  1426 ?    ?   ?   A . n 
A 1 11  ARG 11  1427 ?    ?   ?   A . n 
A 1 12  GLU 12  1428 ?    ?   ?   A . n 
A 1 13  ASN 13  1429 ?    ?   ?   A . n 
A 1 14  LEU 14  1430 ?    ?   ?   A . n 
A 1 15  TYR 15  1431 ?    ?   ?   A . n 
A 1 16  PHE 16  1432 ?    ?   ?   A . n 
A 1 17  GLN 17  1433 ?    ?   ?   A . n 
A 1 18  GLY 18  1434 ?    ?   ?   A . n 
A 1 19  GLU 19  1435 ?    ?   ?   A . n 
A 1 20  THR 20  1436 ?    ?   ?   A . n 
A 1 21  SER 21  1437 ?    ?   ?   A . n 
A 1 22  VAL 22  1438 ?    ?   ?   A . n 
A 1 23  PRO 23  1439 ?    ?   ?   A . n 
A 1 24  PRO 24  1440 ?    ?   ?   A . n 
A 1 25  GLY 25  1441 ?    ?   ?   A . n 
A 1 26  SER 26  1442 ?    ?   ?   A . n 
A 1 27  ALA 27  1443 ?    ?   ?   A . n 
A 1 28  LEU 28  1444 ?    ?   ?   A . n 
A 1 29  VAL 29  1445 ?    ?   ?   A . n 
A 1 30  GLY 30  1446 ?    ?   ?   A . n 
A 1 31  PRO 31  1447 1447 PRO PRO A . n 
A 1 32  SER 32  1448 1448 SER SER A . n 
A 1 33  CYS 33  1449 1449 CYS CYS A . n 
A 1 34  VAL 34  1450 1450 VAL VAL A . n 
A 1 35  MET 35  1451 1451 MET MET A . n 
A 1 36  ASP 36  1452 1452 ASP ASP A . n 
A 1 37  ASP 37  1453 1453 ASP ASP A . n 
A 1 38  PHE 38  1454 1454 PHE PHE A . n 
A 1 39  ARG 39  1455 1455 ARG ARG A . n 
A 1 40  ASP 40  1456 1456 ASP ASP A . n 
A 1 41  PRO 41  1457 1457 PRO PRO A . n 
A 1 42  GLN 42  1458 1458 GLN GLN A . n 
A 1 43  ARG 43  1459 1459 ARG ARG A . n 
A 1 44  TRP 44  1460 1460 TRP TRP A . n 
A 1 45  LYS 45  1461 1461 LYS LYS A . n 
A 1 46  GLU 46  1462 1462 GLU GLU A . n 
A 1 47  CYS 47  1463 1463 CYS CYS A . n 
A 1 48  ALA 48  1464 1464 ALA ALA A . n 
A 1 49  LYS 49  1465 1465 LYS LYS A . n 
A 1 50  GLN 50  1466 1466 GLN GLN A . n 
A 1 51  GLY 51  1467 1467 GLY GLY A . n 
A 1 52  LYS 52  1468 1468 LYS LYS A . n 
A 1 53  MET 53  1469 1469 MET MET A . n 
A 1 54  PRO 54  1470 1470 PRO PRO A . n 
A 1 55  CYS 55  1471 1471 CYS CYS A . n 
A 1 56  TYR 56  1472 1472 TYR TYR A . n 
A 1 57  PHE 57  1473 1473 PHE PHE A . n 
A 1 58  ASP 58  1474 1474 ASP ASP A . n 
A 1 59  LEU 59  1475 1475 LEU LEU A . n 
A 1 60  ILE 60  1476 1476 ILE ILE A . n 
A 1 61  GLU 61  1477 1477 GLU GLU A . n 
A 1 62  GLU 62  1478 1478 GLU GLU A . n 
A 1 63  ASN 63  1479 1479 ASN ASN A . n 
A 1 64  VAL 64  1480 1480 VAL VAL A . n 
A 1 65  TYR 65  1481 1481 TYR TYR A . n 
A 1 66  LEU 66  1482 1482 LEU LEU A . n 
A 1 67  THR 67  1483 1483 THR THR A . n 
A 1 68  GLU 68  1484 1484 GLU GLU A . n 
A 1 69  ARG 69  1485 1485 ARG ARG A . n 
A 1 70  LYS 70  1486 ?    ?   ?   A . n 
A 1 71  LYS 71  1487 ?    ?   ?   A . n 
A 1 72  ASN 72  1488 ?    ?   ?   A . n 
A 1 73  LYS 73  1489 ?    ?   ?   A . n 
A 1 74  SER 74  1490 ?    ?   ?   A . n 
A 1 75  HIS 75  1491 ?    ?   ?   A . n 
A 1 76  ARG 76  1492 ?    ?   ?   A . n 
A 1 77  ASP 77  1493 ?    ?   ?   A . n 
A 1 78  ILE 78  1494 1494 ILE ILE A . n 
A 1 79  LYS 79  1495 1495 LYS LYS A . n 
A 1 80  ARG 80  1496 1496 ARG ARG A . n 
A 1 81  MET 81  1497 1497 MET MET A . n 
A 1 82  GLN 82  1498 1498 GLN GLN A . n 
A 1 83  CYS 83  1499 1499 CYS CYS A . n 
A 1 84  GLU 84  1500 1500 GLU GLU A . n 
A 1 85  CYS 85  1501 1501 CYS CYS A . n 
A 1 86  THR 86  1502 1502 THR THR A . n 
A 1 87  PRO 87  1503 1503 PRO PRO A . n 
A 1 88  LEU 88  1504 1504 LEU LEU A . n 
A 1 89  SER 89  1505 1505 SER SER A . n 
A 1 90  LYS 90  1506 1506 LYS LYS A . n 
A 1 91  ASP 91  1507 1507 ASP ASP A . n 
A 1 92  GLU 92  1508 1508 GLU GLU A . n 
A 1 93  ARG 93  1509 1509 ARG ARG A . n 
A 1 94  ALA 94  1510 1510 ALA ALA A . n 
A 1 95  GLN 95  1511 1511 GLN GLN A . n 
A 1 96  GLY 96  1512 1512 GLY GLY A . n 
A 1 97  GLU 97  1513 1513 GLU GLU A . n 
A 1 98  ILE 98  1514 1514 ILE ILE A . n 
A 1 99  ALA 99  1515 1515 ALA ALA A . n 
A 1 100 CYS 100 1516 1516 CYS CYS A . n 
A 1 101 GLY 101 1517 1517 GLY GLY A . n 
A 1 102 GLU 102 1518 1518 GLU GLU A . n 
A 1 103 ASP 103 1519 1519 ASP ASP A . n 
A 1 104 CYS 104 1520 1520 CYS CYS A . n 
A 1 105 LEU 105 1521 1521 LEU LEU A . n 
A 1 106 ASN 106 1522 1522 ASN ASN A . n 
A 1 107 ARG 107 1523 1523 ARG ARG A . n 
A 1 108 LEU 108 1524 1524 LEU LEU A . n 
A 1 109 LEU 109 1525 1525 LEU LEU A . n 
A 1 110 MET 110 1526 1526 MET MET A . n 
A 1 111 ILE 111 1527 1527 ILE ILE A . n 
A 1 112 GLU 112 1528 1528 GLU GLU A . n 
A 1 113 CYS 113 1529 1529 CYS CYS A . n 
A 1 114 SER 114 1530 1530 SER SER A . n 
A 1 115 SER 115 1531 1531 SER SER A . n 
A 1 116 ARG 116 1532 1532 ARG ARG A . n 
A 1 117 CYS 117 1533 1533 CYS CYS A . n 
A 1 118 PRO 118 1534 1534 PRO PRO A . n 
A 1 119 ASN 119 1535 1535 ASN ASN A . n 
A 1 120 GLY 120 1536 1536 GLY GLY A . n 
A 1 121 ASP 121 1537 1537 ASP ASP A . n 
A 1 122 TYR 122 1538 1538 TYR TYR A . n 
A 1 123 CYS 123 1539 1539 CYS CYS A . n 
A 1 124 SER 124 1540 1540 SER SER A . n 
A 1 125 ASN 125 1541 1541 ASN ASN A . n 
A 1 126 ARG 126 1542 1542 ARG ARG A . n 
A 1 127 ARG 127 1543 1543 ARG ARG A . n 
A 1 128 PHE 128 1544 1544 PHE PHE A . n 
A 1 129 GLN 129 1545 1545 GLN GLN A . n 
A 1 130 ARG 130 1546 1546 ARG ARG A . n 
A 1 131 LYS 131 1547 1547 LYS LYS A . n 
A 1 132 GLN 132 1548 1548 GLN GLN A . n 
A 1 133 HIS 133 1549 1549 HIS HIS A . n 
A 1 134 ALA 134 1550 1550 ALA ALA A . n 
A 1 135 ASP 135 1551 1551 ASP ASP A . n 
A 1 136 VAL 136 1552 1552 VAL VAL A . n 
A 1 137 GLU 137 1553 1553 GLU GLU A . n 
A 1 138 VAL 138 1554 1554 VAL VAL A . n 
A 1 139 ILE 139 1555 1555 ILE ILE A . n 
A 1 140 LEU 140 1556 1556 LEU LEU A . n 
A 1 141 THR 141 1557 1557 THR THR A . n 
A 1 142 GLU 142 1558 1558 GLU GLU A . n 
A 1 143 LYS 143 1559 1559 LYS LYS A . n 
A 1 144 LYS 144 1560 1560 LYS LYS A . n 
A 1 145 GLY 145 1561 1561 GLY GLY A . n 
A 1 146 TRP 146 1562 1562 TRP TRP A . n 
A 1 147 GLY 147 1563 1563 GLY GLY A . n 
A 1 148 LEU 148 1564 1564 LEU LEU A . n 
A 1 149 ARG 149 1565 1565 ARG ARG A . n 
A 1 150 ALA 150 1566 1566 ALA ALA A . n 
A 1 151 ALA 151 1567 1567 ALA ALA A . n 
A 1 152 LYS 152 1568 1568 LYS LYS A . n 
A 1 153 ASP 153 1569 1569 ASP ASP A . n 
A 1 154 LEU 154 1570 1570 LEU LEU A . n 
A 1 155 PRO 155 1571 1571 PRO PRO A . n 
A 1 156 SER 156 1572 1572 SER SER A . n 
A 1 157 ASN 157 1573 1573 ASN ASN A . n 
A 1 158 THR 158 1574 1574 THR THR A . n 
A 1 159 PHE 159 1575 1575 PHE PHE A . n 
A 1 160 VAL 160 1576 1576 VAL VAL A . n 
A 1 161 LEU 161 1577 1577 LEU LEU A . n 
A 1 162 GLU 162 1578 1578 GLU GLU A . n 
A 1 163 TYR 163 1579 1579 TYR TYR A . n 
A 1 164 CYS 164 1580 1580 CYS CYS A . n 
A 1 165 GLY 165 1581 1581 GLY GLY A . n 
A 1 166 GLU 166 1582 1582 GLU GLU A . n 
A 1 167 VAL 167 1583 1583 VAL VAL A . n 
A 1 168 LEU 168 1584 1584 LEU LEU A . n 
A 1 169 ASP 169 1585 1585 ASP ASP A . n 
A 1 170 HIS 170 1586 1586 HIS HIS A . n 
A 1 171 LYS 171 1587 1587 LYS LYS A . n 
A 1 172 GLU 172 1588 1588 GLU GLU A . n 
A 1 173 PHE 173 1589 1589 PHE PHE A . n 
A 1 174 LYS 174 1590 1590 LYS LYS A . n 
A 1 175 ALA 175 1591 1591 ALA ALA A . n 
A 1 176 ARG 176 1592 1592 ARG ARG A . n 
A 1 177 VAL 177 1593 1593 VAL VAL A . n 
A 1 178 LYS 178 1594 1594 LYS LYS A . n 
A 1 179 GLU 179 1595 1595 GLU GLU A . n 
A 1 180 TYR 180 1596 1596 TYR TYR A . n 
A 1 181 ALA 181 1597 1597 ALA ALA A . n 
A 1 182 ARG 182 1598 1598 ARG ARG A . n 
A 1 183 ASN 183 1599 1599 ASN ASN A . n 
A 1 184 LYS 184 1600 1600 LYS LYS A . n 
A 1 185 ASN 185 1601 1601 ASN ASN A . n 
A 1 186 ILE 186 1602 1602 ILE ILE A . n 
A 1 187 HIS 187 1603 1603 HIS HIS A . n 
A 1 188 TYR 188 1604 1604 TYR TYR A . n 
A 1 189 TYR 189 1605 1605 TYR TYR A . n 
A 1 190 PHE 190 1606 1606 PHE PHE A . n 
A 1 191 MET 191 1607 1607 MET MET A . n 
A 1 192 ALA 192 1608 1608 ALA ALA A . n 
A 1 193 PRO 193 1609 1609 PRO PRO A . n 
A 1 194 LYS 194 1610 1610 LYS LYS A . n 
A 1 195 ASN 195 1611 1611 ASN ASN A . n 
A 1 196 ASP 196 1612 1612 ASP ASP A . n 
A 1 197 GLU 197 1613 1613 GLU GLU A . n 
A 1 198 ILE 198 1614 1614 ILE ILE A . n 
A 1 199 ILE 199 1615 1615 ILE ILE A . n 
A 1 200 ASP 200 1616 1616 ASP ASP A . n 
A 1 201 ALA 201 1617 1617 ALA ALA A . n 
A 1 202 THR 202 1618 1618 THR THR A . n 
A 1 203 GLN 203 1619 1619 GLN GLN A . n 
A 1 204 LYS 204 1620 1620 LYS LYS A . n 
A 1 205 GLY 205 1621 1621 GLY GLY A . n 
A 1 206 ASN 206 1622 1622 ASN ASN A . n 
A 1 207 CYS 207 1623 1623 CYS CYS A . n 
A 1 208 SER 208 1624 1624 SER SER A . n 
A 1 209 ARG 209 1625 1625 ARG ARG A . n 
A 1 210 PHE 210 1626 1626 PHE PHE A . n 
A 1 211 MET 211 1627 1627 MET MET A . n 
A 1 212 ASN 212 1628 1628 ASN ASN A . n 
A 1 213 HIS 213 1629 1629 HIS HIS A . n 
A 1 214 SER 214 1630 1630 SER SER A . n 
A 1 215 CYS 215 1631 1631 CYS CYS A . n 
A 1 216 GLU 216 1632 1632 GLU GLU A . n 
A 1 217 PRO 217 1633 1633 PRO PRO A . n 
A 1 218 ASN 218 1634 1634 ASN ASN A . n 
A 1 219 CYS 219 1635 1635 CYS CYS A . n 
A 1 220 GLU 220 1636 1636 GLU GLU A . n 
A 1 221 THR 221 1637 1637 THR THR A . n 
A 1 222 GLN 222 1638 1638 GLN GLN A . n 
A 1 223 LYS 223 1639 1639 LYS LYS A . n 
A 1 224 TRP 224 1640 1640 TRP TRP A . n 
A 1 225 THR 225 1641 1641 THR THR A . n 
A 1 226 VAL 226 1642 1642 VAL VAL A . n 
A 1 227 ASN 227 1643 1643 ASN ASN A . n 
A 1 228 GLY 228 1644 1644 GLY GLY A . n 
A 1 229 GLN 229 1645 1645 GLN GLN A . n 
A 1 230 LEU 230 1646 1646 LEU LEU A . n 
A 1 231 ARG 231 1647 1647 ARG ARG A . n 
A 1 232 VAL 232 1648 1648 VAL VAL A . n 
A 1 233 GLY 233 1649 1649 GLY GLY A . n 
A 1 234 PHE 234 1650 1650 PHE PHE A . n 
A 1 235 PHE 235 1651 1651 PHE PHE A . n 
A 1 236 THR 236 1652 1652 THR THR A . n 
A 1 237 THR 237 1653 1653 THR THR A . n 
A 1 238 LYS 238 1654 1654 LYS LYS A . n 
A 1 239 LEU 239 1655 1655 LEU LEU A . n 
A 1 240 VAL 240 1656 1656 VAL VAL A . n 
A 1 241 PRO 241 1657 1657 PRO PRO A . n 
A 1 242 SER 242 1658 1658 SER SER A . n 
A 1 243 GLY 243 1659 1659 GLY GLY A . n 
A 1 244 SER 244 1660 1660 SER SER A . n 
A 1 245 GLU 245 1661 1661 GLU GLU A . n 
A 1 246 LEU 246 1662 1662 LEU LEU A . n 
A 1 247 THR 247 1663 1663 THR THR A . n 
A 1 248 PHE 248 1664 1664 PHE PHE A . n 
A 1 249 ASP 249 1665 1665 ASP ASP A . n 
A 1 250 TYR 250 1666 1666 TYR TYR A . n 
A 1 251 GLN 251 1667 1667 GLN GLN A . n 
A 1 252 PHE 252 1668 1668 PHE PHE A . n 
A 1 253 GLN 253 1669 1669 GLN GLN A . n 
A 1 254 ARG 254 1670 1670 ARG ARG A . n 
A 1 255 TYR 255 1671 1671 TYR TYR A . n 
A 1 256 GLY 256 1672 1672 GLY GLY A . n 
A 1 257 LYS 257 1673 1673 LYS LYS A . n 
A 1 258 GLU 258 1674 1674 GLU GLU A . n 
A 1 259 ALA 259 1675 1675 ALA ALA A . n 
A 1 260 GLN 260 1676 1676 GLN GLN A . n 
A 1 261 LYS 261 1677 1677 LYS LYS A . n 
A 1 262 CYS 262 1678 1678 CYS CYS A . n 
A 1 263 PHE 263 1679 1679 PHE PHE A . n 
A 1 264 CYS 264 1680 1680 CYS CYS A . n 
A 1 265 GLY 265 1681 1681 GLY GLY A . n 
A 1 266 SER 266 1682 1682 SER SER A . n 
A 1 267 ALA 267 1683 1683 ALA ALA A . n 
A 1 268 ASN 268 1684 1684 ASN ASN A . n 
A 1 269 CYS 269 1685 1685 CYS CYS A . n 
A 1 270 ARG 270 1686 1686 ARG ARG A . n 
A 1 271 GLY 271 1687 1687 GLY GLY A . n 
A 1 272 TYR 272 1688 1688 TYR TYR A . n 
A 1 273 LEU 273 1689 1689 LEU LEU A . n 
A 1 274 GLY 274 1690 1690 GLY GLY A . n 
A 1 275 GLY 275 1691 1691 GLY GLY A . n 
A 1 276 GLU 276 1692 1692 GLU GLU A . n 
A 1 277 ASN 277 1693 1693 ASN ASN A . n 
A 1 278 ARG 278 1694 1694 ARG ARG A . n 
A 1 279 VAL 279 1695 1695 VAL VAL A . n 
A 1 280 SER 280 1696 1696 SER SER A . n 
A 1 281 ILE 281 1697 1697 ILE ILE A . n 
A 1 282 ARG 282 1698 1698 ARG ARG A . n 
A 1 283 ALA 283 1699 1699 ALA ALA A . n 
A 1 284 ALA 284 1700 1700 ALA ALA A . n 
A 1 285 GLY 285 1701 1701 GLY GLY A . n 
A 1 286 GLY 286 1702 1702 GLY GLY A . n 
A 1 287 LYS 287 1703 1703 LYS LYS A . n 
A 1 288 MET 288 1704 1704 MET MET A . n 
A 1 289 LYS 289 1705 ?    ?   ?   A . n 
A 1 290 LYS 290 1706 ?    ?   ?   A . n 
A 1 291 GLU 291 1707 ?    ?   ?   A . n 
A 1 292 ARG 292 1708 ?    ?   ?   A . n 
A 1 293 SER 293 1709 ?    ?   ?   A . n 
A 1 294 ARG 294 1710 ?    ?   ?   A . n 
A 1 295 LYS 295 1711 ?    ?   ?   A . n 
B 2 1   ALA 1   29   29   ALA ALA B . n 
B 2 2   PRO 2   30   30   PRO PRO B . n 
B 2 3   SER 3   31   31   SER SER B . n 
B 2 4   THR 4   32   32   THR THR B . n 
B 2 5   GLY 5   33   33   GLY GLY B . n 
B 2 6   GLY 6   34   34   GLY GLY B . n 
B 2 7   VAL 7   35   35   VAL VAL B . n 
B 2 8   MET 8   36   36   MET MET B . n 
B 2 9   LYS 9   37   37   LYS LYS B . n 
B 2 10  PRO 10  38   38   PRO PRO B . n 
B 2 11  HIS 11  39   39   HIS HIS B . n 
B 2 12  ARG 12  40   ?    ?   ?   B . n 
B 2 13  TYR 13  41   ?    ?   ?   B . n 
B 2 14  ARG 14  42   ?    ?   ?   B . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 3 ZN  1  1801 1801 ZN  ZN  A . 
D 3 ZN  1  1802 1802 ZN  ZN  A . 
E 3 ZN  1  1803 1803 ZN  ZN  A . 
F 4 SAM 1  1804 1804 SAM SAM A . 
G 5 HOH 1  1901 22   HOH HOH A . 
G 5 HOH 2  1902 38   HOH HOH A . 
G 5 HOH 3  1903 8    HOH HOH A . 
G 5 HOH 4  1904 2    HOH HOH A . 
G 5 HOH 5  1905 3    HOH HOH A . 
G 5 HOH 6  1906 42   HOH HOH A . 
G 5 HOH 7  1907 6    HOH HOH A . 
G 5 HOH 8  1908 18   HOH HOH A . 
G 5 HOH 9  1909 12   HOH HOH A . 
G 5 HOH 10 1910 9    HOH HOH A . 
G 5 HOH 11 1911 20   HOH HOH A . 
G 5 HOH 12 1912 33   HOH HOH A . 
G 5 HOH 13 1913 39   HOH HOH A . 
G 5 HOH 14 1914 14   HOH HOH A . 
G 5 HOH 15 1915 27   HOH HOH A . 
G 5 HOH 16 1916 24   HOH HOH A . 
G 5 HOH 17 1917 32   HOH HOH A . 
G 5 HOH 18 1918 34   HOH HOH A . 
G 5 HOH 19 1919 21   HOH HOH A . 
G 5 HOH 20 1920 25   HOH HOH A . 
G 5 HOH 21 1921 16   HOH HOH A . 
G 5 HOH 22 1922 7    HOH HOH A . 
G 5 HOH 23 1923 4    HOH HOH A . 
G 5 HOH 24 1924 40   HOH HOH A . 
G 5 HOH 25 1925 30   HOH HOH A . 
G 5 HOH 26 1926 10   HOH HOH A . 
G 5 HOH 27 1927 23   HOH HOH A . 
G 5 HOH 28 1928 1    HOH HOH A . 
G 5 HOH 29 1929 5    HOH HOH A . 
G 5 HOH 30 1930 41   HOH HOH A . 
G 5 HOH 31 1931 15   HOH HOH A . 
G 5 HOH 32 1932 26   HOH HOH A . 
G 5 HOH 33 1933 11   HOH HOH A . 
G 5 HOH 34 1934 13   HOH HOH A . 
G 5 HOH 35 1935 35   HOH HOH A . 
G 5 HOH 36 1936 28   HOH HOH A . 
G 5 HOH 37 1937 19   HOH HOH A . 
G 5 HOH 38 1938 36   HOH HOH A . 
G 5 HOH 39 1939 37   HOH HOH A . 
G 5 HOH 40 1940 17   HOH HOH A . 
G 5 HOH 41 1941 29   HOH HOH A . 
G 5 HOH 42 1942 31   HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 B HIS 39 ? CG  ? B HIS 11 CG  
2 1 Y 1 B HIS 39 ? ND1 ? B HIS 11 ND1 
3 1 Y 1 B HIS 39 ? CD2 ? B HIS 11 CD2 
4 1 Y 1 B HIS 39 ? CE1 ? B HIS 11 CE1 
5 1 Y 1 B HIS 39 ? NE2 ? B HIS 11 NE2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.21_5207 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? autoPROC ? ? ? .         2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? autoPROC ? ? ? .         3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER   ? ? ? .         4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8RZU 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     59.718 
_cell.length_a_esd                 ? 
_cell.length_b                     77.408 
_cell.length_b_esd                 ? 
_cell.length_c                     77.884 
_cell.length_c_esd                 ? 
_cell.volume                       360030.546 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8RZU 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            'P 2ac 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8RZU 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.53 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          51.29 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '32% w/v PEG 4K, 100mM Tris, 800mM LiCl, pH 8.5' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2019-04-26 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97857 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SOLEIL BEAMLINE PROXIMA 1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97857 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   'PROXIMA 1' 
_diffrn_source.pdbx_synchrotron_site       SOLEIL 
# 
_reflns.B_iso_Wilson_estimate                          49.18 
_reflns.entry_id                                       8RZU 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.186 
_reflns.d_resolution_low                               47.283 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     19287 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100.0 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                13.4 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          19.3 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.078 
_reflns.pdbx_Rpim_I_all                                0.021 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.075 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.186 
_reflns_shell.d_res_low                                     2.223 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           2.2 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             961 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               1.262 
_reflns_shell.pdbx_Rpim_I_all                               0.337 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.911 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.215 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               63.95 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8RZU 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.19 
_refine.ls_d_res_low                             40.42 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     19257 
_refine.ls_number_reflns_R_free                  973 
_refine.ls_number_reflns_R_work                  18284 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.84 
_refine.ls_percent_reflns_R_free                 5.05 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2235 
_refine.ls_R_factor_R_free                       0.2644 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2212 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.36 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 33.0813 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.3039 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.19 
_refine_hist.d_res_low                        40.42 
_refine_hist.number_atoms_solvent             42 
_refine_hist.number_atoms_total               2151 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2079 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         30 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0079  ? 2148 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.0074  ? 2881 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0541  ? 294  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0055  ? 378  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 18.4284 ? 849  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.19 2.30  . . 102 2590 99.70  . . . . 0.3162 . . . . . . . . . . . 0.4111 
'X-RAY DIFFRACTION' 2.30 2.44  . . 141 2581 99.85  . . . . 0.2864 . . . . . . . . . . . 0.3599 
'X-RAY DIFFRACTION' 2.45 2.63  . . 156 2537 99.85  . . . . 0.2820 . . . . . . . . . . . 0.3374 
'X-RAY DIFFRACTION' 2.63 2.90  . . 133 2596 99.85  . . . . 0.2575 . . . . . . . . . . . 0.2780 
'X-RAY DIFFRACTION' 2.90 3.32  . . 131 2613 99.85  . . . . 0.2713 . . . . . . . . . . . 0.3138 
'X-RAY DIFFRACTION' 3.32 4.18  . . 146 2620 100.00 . . . . 0.2094 . . . . . . . . . . . 0.2735 
'X-RAY DIFFRACTION' 4.18 40.42 . . 164 2747 99.83  . . . . 0.1758 . . . . . . . . . . . 0.2093 
# 
_struct.entry_id                     8RZU 
_struct.title                        'Structure of human SETD2 L1609P mutant in complex with SAM and H3K36M peptide' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8RZU 
_struct_keywords.text            'Histone methyl-transferase, TRANSFERASE' 
_struct_keywords.pdbx_keywords   TRANSFERASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 3 ? 
E N N 3 ? 
F N N 4 ? 
G N N 5 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP SETD2_HUMAN  Q9BYW2 ? 1 
;QGETSVPPGSALVGPSCVMDDFRDPQRWKECAKQGKMPCYFDLIEENVYLTERKKNKSHRDIKRMQCECTPLSKDERAQG
EIACGEDCLNRLLMIECSSRCPNGDYCSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKAR
VKEYARNKNIHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYG
KEAQKCFCGSANCRGYLGGENRVSIRAAGGKMKKERSRK
;
1433 
2 UNP B2R6Y1_HUMAN B2R6Y1 ? 2 APSTGGVKKPHRYR 30   
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8RZU A 17 ? 295 ? Q9BYW2 1433 ? 1711 ? 1433 1711 
2 2 8RZU B 1  ? 14  ? B2R6Y1 30   ? 43   ? 29   42   
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8RZU MET A 1   ? UNP Q9BYW2 ?   ?    'initiating methionine' 1417 1  
1 8RZU HIS A 2   ? UNP Q9BYW2 ?   ?    'expression tag'        1418 2  
1 8RZU HIS A 3   ? UNP Q9BYW2 ?   ?    'expression tag'        1419 3  
1 8RZU HIS A 4   ? UNP Q9BYW2 ?   ?    'expression tag'        1420 4  
1 8RZU HIS A 5   ? UNP Q9BYW2 ?   ?    'expression tag'        1421 5  
1 8RZU HIS A 6   ? UNP Q9BYW2 ?   ?    'expression tag'        1422 6  
1 8RZU HIS A 7   ? UNP Q9BYW2 ?   ?    'expression tag'        1423 7  
1 8RZU SER A 8   ? UNP Q9BYW2 ?   ?    'expression tag'        1424 8  
1 8RZU SER A 9   ? UNP Q9BYW2 ?   ?    'expression tag'        1425 9  
1 8RZU GLY A 10  ? UNP Q9BYW2 ?   ?    'expression tag'        1426 10 
1 8RZU ARG A 11  ? UNP Q9BYW2 ?   ?    'expression tag'        1427 11 
1 8RZU GLU A 12  ? UNP Q9BYW2 ?   ?    'expression tag'        1428 12 
1 8RZU ASN A 13  ? UNP Q9BYW2 ?   ?    'expression tag'        1429 13 
1 8RZU LEU A 14  ? UNP Q9BYW2 ?   ?    'expression tag'        1430 14 
1 8RZU TYR A 15  ? UNP Q9BYW2 ?   ?    'expression tag'        1431 15 
1 8RZU PHE A 16  ? UNP Q9BYW2 ?   ?    'expression tag'        1432 16 
1 8RZU PRO A 193 ? UNP Q9BYW2 LEU 1609 variant                 1609 17 
2 8RZU MET B 8   ? UNP B2R6Y1 LYS 37   conflict                36   18 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 1840  ? 
1 MORE         -24   ? 
1 'SSA (A^2)'  14210 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 ASP A 36  ? ARG A 39  ? ASP A 1452 ARG A 1455 5 ? 4  
HELX_P HELX_P2 AA2 ASP A 40  ? GLN A 50  ? ASP A 1456 GLN A 1466 1 ? 11 
HELX_P HELX_P3 AA3 SER A 89  ? GLN A 95  ? SER A 1505 GLN A 1511 1 ? 7  
HELX_P HELX_P4 AA4 CYS A 104 ? LEU A 109 ? CYS A 1520 LEU A 1525 1 ? 6  
HELX_P HELX_P5 AA5 ASN A 119 ? CYS A 123 ? ASN A 1535 CYS A 1539 5 ? 5  
HELX_P HELX_P6 AA6 ARG A 126 ? LYS A 131 ? ARG A 1542 LYS A 1547 1 ? 6  
HELX_P HELX_P7 AA7 ASP A 169 ? LYS A 184 ? ASP A 1585 LYS A 1600 1 ? 16 
HELX_P HELX_P8 AA8 ASN A 206 ? MET A 211 ? ASN A 1622 MET A 1627 5 ? 6  
HELX_P HELX_P9 AA9 SER A 280 ? GLY A 285 ? SER A 1696 GLY A 1701 1 ? 6  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1  metalc ? ? A CYS 83  SG ? ? ? 1_555 C ZN . ZN ? ? A CYS 1499 A ZN 1801 1_555 ? ? ? ? ? ? ? 2.207 ? ? 
metalc2  metalc ? ? A CYS 85  SG ? ? ? 1_555 C ZN . ZN ? ? A CYS 1501 A ZN 1801 1_555 ? ? ? ? ? ? ? 2.178 ? ? 
metalc3  metalc ? ? A CYS 100 SG ? ? ? 1_555 C ZN . ZN ? ? A CYS 1516 A ZN 1801 1_555 ? ? ? ? ? ? ? 2.434 ? ? 
metalc4  metalc ? ? A CYS 100 SG ? ? ? 1_555 D ZN . ZN ? ? A CYS 1516 A ZN 1802 1_555 ? ? ? ? ? ? ? 2.186 ? ? 
metalc5  metalc ? ? A CYS 104 SG ? ? ? 1_555 C ZN . ZN ? ? A CYS 1520 A ZN 1801 1_555 ? ? ? ? ? ? ? 2.472 ? ? 
metalc6  metalc ? ? A CYS 113 SG ? ? ? 1_555 D ZN . ZN ? ? A CYS 1529 A ZN 1802 1_555 ? ? ? ? ? ? ? 2.338 ? ? 
metalc7  metalc ? ? A CYS 117 SG ? ? ? 1_555 D ZN . ZN ? ? A CYS 1533 A ZN 1802 1_555 ? ? ? ? ? ? ? 2.506 ? ? 
metalc8  metalc ? ? A CYS 123 SG ? ? ? 1_555 D ZN . ZN ? ? A CYS 1539 A ZN 1802 1_555 ? ? ? ? ? ? ? 2.295 ? ? 
metalc9  metalc ? ? A CYS 215 SG ? ? ? 1_555 E ZN . ZN ? ? A CYS 1631 A ZN 1803 1_555 ? ? ? ? ? ? ? 2.208 ? ? 
metalc10 metalc ? ? A CYS 262 SG ? ? ? 1_555 E ZN . ZN ? ? A CYS 1678 A ZN 1803 1_555 ? ? ? ? ? ? ? 2.231 ? ? 
metalc11 metalc ? ? A CYS 264 SG ? ? ? 1_555 E ZN . ZN ? ? A CYS 1680 A ZN 1803 1_555 ? ? ? ? ? ? ? 2.191 ? ? 
metalc12 metalc ? ? A CYS 269 SG ? ? ? 1_555 E ZN . ZN ? ? A CYS 1685 A ZN 1803 1_555 ? ? ? ? ? ? ? 2.490 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  SG ? A CYS 83  ? A CYS 1499 ? 1_555 ZN ? C ZN . ? A ZN 1801 ? 1_555 SG ? A CYS 85  ? A CYS 1501 ? 1_555 103.0 ? 
2  SG ? A CYS 83  ? A CYS 1499 ? 1_555 ZN ? C ZN . ? A ZN 1801 ? 1_555 SG ? A CYS 100 ? A CYS 1516 ? 1_555 106.9 ? 
3  SG ? A CYS 85  ? A CYS 1501 ? 1_555 ZN ? C ZN . ? A ZN 1801 ? 1_555 SG ? A CYS 100 ? A CYS 1516 ? 1_555 119.5 ? 
4  SG ? A CYS 83  ? A CYS 1499 ? 1_555 ZN ? C ZN . ? A ZN 1801 ? 1_555 SG ? A CYS 104 ? A CYS 1520 ? 1_555 111.6 ? 
5  SG ? A CYS 85  ? A CYS 1501 ? 1_555 ZN ? C ZN . ? A ZN 1801 ? 1_555 SG ? A CYS 104 ? A CYS 1520 ? 1_555 104.4 ? 
6  SG ? A CYS 100 ? A CYS 1516 ? 1_555 ZN ? C ZN . ? A ZN 1801 ? 1_555 SG ? A CYS 104 ? A CYS 1520 ? 1_555 111.2 ? 
7  SG ? A CYS 100 ? A CYS 1516 ? 1_555 ZN ? D ZN . ? A ZN 1802 ? 1_555 SG ? A CYS 113 ? A CYS 1529 ? 1_555 113.6 ? 
8  SG ? A CYS 100 ? A CYS 1516 ? 1_555 ZN ? D ZN . ? A ZN 1802 ? 1_555 SG ? A CYS 117 ? A CYS 1533 ? 1_555 95.0  ? 
9  SG ? A CYS 113 ? A CYS 1529 ? 1_555 ZN ? D ZN . ? A ZN 1802 ? 1_555 SG ? A CYS 117 ? A CYS 1533 ? 1_555 117.2 ? 
10 SG ? A CYS 100 ? A CYS 1516 ? 1_555 ZN ? D ZN . ? A ZN 1802 ? 1_555 SG ? A CYS 123 ? A CYS 1539 ? 1_555 107.6 ? 
11 SG ? A CYS 113 ? A CYS 1529 ? 1_555 ZN ? D ZN . ? A ZN 1802 ? 1_555 SG ? A CYS 123 ? A CYS 1539 ? 1_555 108.7 ? 
12 SG ? A CYS 117 ? A CYS 1533 ? 1_555 ZN ? D ZN . ? A ZN 1802 ? 1_555 SG ? A CYS 123 ? A CYS 1539 ? 1_555 113.9 ? 
13 SG ? A CYS 215 ? A CYS 1631 ? 1_555 ZN ? E ZN . ? A ZN 1803 ? 1_555 SG ? A CYS 262 ? A CYS 1678 ? 1_555 112.6 ? 
14 SG ? A CYS 215 ? A CYS 1631 ? 1_555 ZN ? E ZN . ? A ZN 1803 ? 1_555 SG ? A CYS 264 ? A CYS 1680 ? 1_555 116.1 ? 
15 SG ? A CYS 262 ? A CYS 1678 ? 1_555 ZN ? E ZN . ? A ZN 1803 ? 1_555 SG ? A CYS 264 ? A CYS 1680 ? 1_555 107.9 ? 
16 SG ? A CYS 215 ? A CYS 1631 ? 1_555 ZN ? E ZN . ? A ZN 1803 ? 1_555 SG ? A CYS 269 ? A CYS 1685 ? 1_555 109.5 ? 
17 SG ? A CYS 262 ? A CYS 1678 ? 1_555 ZN ? E ZN . ? A ZN 1803 ? 1_555 SG ? A CYS 269 ? A CYS 1685 ? 1_555 101.1 ? 
18 SG ? A CYS 264 ? A CYS 1680 ? 1_555 ZN ? E ZN . ? A ZN 1803 ? 1_555 SG ? A CYS 269 ? A CYS 1685 ? 1_555 108.6 ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 2 ? 
AA3 ? 4 ? 
AA4 ? 3 ? 
AA5 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? parallel      
AA2 1 2 ? parallel      
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA5 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 SER A 32  ? VAL A 34  ? SER A 1448 VAL A 1450 
AA1 2 VAL A 136 ? LEU A 140 ? VAL A 1552 LEU A 1556 
AA1 3 TRP A 146 ? ALA A 150 ? TRP A 1562 ALA A 1566 
AA1 4 GLU A 245 ? PHE A 248 ? GLU A 1661 PHE A 1664 
AA1 5 ASN A 212 ? HIS A 213 ? ASN A 1628 HIS A 1629 
AA2 1 ASP A 58  ? LEU A 59  ? ASP A 1474 LEU A 1475 
AA2 2 LYS A 204 ? GLY A 205 ? LYS A 1620 GLY A 1621 
AA3 1 VAL A 64  ? TYR A 65  ? VAL A 1480 TYR A 1481 
AA3 2 GLU A 166 ? LEU A 168 ? GLU A 1582 LEU A 1584 
AA3 3 ILE A 198 ? ASP A 200 ? ILE A 1614 ASP A 1616 
AA3 4 PHE A 190 ? MET A 191 ? PHE A 1606 MET A 1607 
AA4 1 PHE A 159 ? GLU A 162 ? PHE A 1575 GLU A 1578 
AA4 2 GLN A 229 ? THR A 236 ? GLN A 1645 THR A 1652 
AA4 3 CYS A 219 ? VAL A 226 ? CYS A 1635 VAL A 1642 
AA5 1 GLN A 253 ? ARG A 254 ? GLN A 1669 ARG A 1670 
AA5 2 GLY B 6   ? VAL B 7   ? GLY B 34   VAL B 35   
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N CYS A 33  ? N CYS A 1449 O VAL A 138 ? O VAL A 1554 
AA1 2 3 N ILE A 139 ? N ILE A 1555 O GLY A 147 ? O GLY A 1563 
AA1 3 4 N LEU A 148 ? N LEU A 1564 O LEU A 246 ? O LEU A 1662 
AA1 4 5 O PHE A 248 ? O PHE A 1664 N ASN A 212 ? N ASN A 1628 
AA2 1 2 N ASP A 58  ? N ASP A 1474 O GLY A 205 ? O GLY A 1621 
AA3 1 2 N VAL A 64  ? N VAL A 1480 O VAL A 167 ? O VAL A 1583 
AA3 2 3 N GLU A 166 ? N GLU A 1582 O ASP A 200 ? O ASP A 1616 
AA3 3 4 O ILE A 199 ? O ILE A 1615 N MET A 191 ? N MET A 1607 
AA4 1 2 N VAL A 160 ? N VAL A 1576 O PHE A 234 ? O PHE A 1650 
AA4 2 3 O ARG A 231 ? O ARG A 1647 N TRP A 224 ? N TRP A 1640 
AA5 1 2 N GLN A 253 ? N GLN A 1669 O VAL B 7   ? O VAL B 35   
# 
_pdbx_entry_details.entry_id                   8RZU 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   O 
_pdbx_validate_close_contact.auth_asym_id_1   A 
_pdbx_validate_close_contact.auth_comp_id_1   GLY 
_pdbx_validate_close_contact.auth_seq_id_1    1701 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   O 
_pdbx_validate_close_contact.auth_asym_id_2   A 
_pdbx_validate_close_contact.auth_comp_id_2   HOH 
_pdbx_validate_close_contact.auth_seq_id_2    1901 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             1.89 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 THR A 1483 ? ? 70.19   -0.85   
2 1 MET A 1497 ? ? -119.71 68.34   
3 1 VAL A 1576 ? ? -92.61  -70.25  
4 1 ASN A 1622 ? ? -125.28 -168.82 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x,y+1/2,-z+1/2 
4 -x+1/2,-y,z+1/2 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 1417 ? A MET 1   
2  1 Y 1 A HIS 1418 ? A HIS 2   
3  1 Y 1 A HIS 1419 ? A HIS 3   
4  1 Y 1 A HIS 1420 ? A HIS 4   
5  1 Y 1 A HIS 1421 ? A HIS 5   
6  1 Y 1 A HIS 1422 ? A HIS 6   
7  1 Y 1 A HIS 1423 ? A HIS 7   
8  1 Y 1 A SER 1424 ? A SER 8   
9  1 Y 1 A SER 1425 ? A SER 9   
10 1 Y 1 A GLY 1426 ? A GLY 10  
11 1 Y 1 A ARG 1427 ? A ARG 11  
12 1 Y 1 A GLU 1428 ? A GLU 12  
13 1 Y 1 A ASN 1429 ? A ASN 13  
14 1 Y 1 A LEU 1430 ? A LEU 14  
15 1 Y 1 A TYR 1431 ? A TYR 15  
16 1 Y 1 A PHE 1432 ? A PHE 16  
17 1 Y 1 A GLN 1433 ? A GLN 17  
18 1 Y 1 A GLY 1434 ? A GLY 18  
19 1 Y 1 A GLU 1435 ? A GLU 19  
20 1 Y 1 A THR 1436 ? A THR 20  
21 1 Y 1 A SER 1437 ? A SER 21  
22 1 Y 1 A VAL 1438 ? A VAL 22  
23 1 Y 1 A PRO 1439 ? A PRO 23  
24 1 Y 1 A PRO 1440 ? A PRO 24  
25 1 Y 1 A GLY 1441 ? A GLY 25  
26 1 Y 1 A SER 1442 ? A SER 26  
27 1 Y 1 A ALA 1443 ? A ALA 27  
28 1 Y 1 A LEU 1444 ? A LEU 28  
29 1 Y 1 A VAL 1445 ? A VAL 29  
30 1 Y 1 A GLY 1446 ? A GLY 30  
31 1 Y 1 A LYS 1486 ? A LYS 70  
32 1 Y 1 A LYS 1487 ? A LYS 71  
33 1 Y 1 A ASN 1488 ? A ASN 72  
34 1 Y 1 A LYS 1489 ? A LYS 73  
35 1 Y 1 A SER 1490 ? A SER 74  
36 1 Y 1 A HIS 1491 ? A HIS 75  
37 1 Y 1 A ARG 1492 ? A ARG 76  
38 1 Y 1 A ASP 1493 ? A ASP 77  
39 1 Y 1 A LYS 1705 ? A LYS 289 
40 1 Y 1 A LYS 1706 ? A LYS 290 
41 1 Y 1 A GLU 1707 ? A GLU 291 
42 1 Y 1 A ARG 1708 ? A ARG 292 
43 1 Y 1 A SER 1709 ? A SER 293 
44 1 Y 1 A ARG 1710 ? A ARG 294 
45 1 Y 1 A LYS 1711 ? A LYS 295 
46 1 Y 1 B ARG 40   ? B ARG 12  
47 1 Y 1 B TYR 41   ? B TYR 13  
48 1 Y 1 B ARG 42   ? B ARG 14  
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N      N  N N 1   
ALA CA     C  N S 2   
ALA C      C  N N 3   
ALA O      O  N N 4   
ALA CB     C  N N 5   
ALA OXT    O  N N 6   
ALA H      H  N N 7   
ALA H2     H  N N 8   
ALA HA     H  N N 9   
ALA HB1    H  N N 10  
ALA HB2    H  N N 11  
ALA HB3    H  N N 12  
ALA HXT    H  N N 13  
ARG N      N  N N 14  
ARG CA     C  N S 15  
ARG C      C  N N 16  
ARG O      O  N N 17  
ARG CB     C  N N 18  
ARG CG     C  N N 19  
ARG CD     C  N N 20  
ARG NE     N  N N 21  
ARG CZ     C  N N 22  
ARG NH1    N  N N 23  
ARG NH2    N  N N 24  
ARG OXT    O  N N 25  
ARG H      H  N N 26  
ARG H2     H  N N 27  
ARG HA     H  N N 28  
ARG HB2    H  N N 29  
ARG HB3    H  N N 30  
ARG HG2    H  N N 31  
ARG HG3    H  N N 32  
ARG HD2    H  N N 33  
ARG HD3    H  N N 34  
ARG HE     H  N N 35  
ARG HH11   H  N N 36  
ARG HH12   H  N N 37  
ARG HH21   H  N N 38  
ARG HH22   H  N N 39  
ARG HXT    H  N N 40  
ASN N      N  N N 41  
ASN CA     C  N S 42  
ASN C      C  N N 43  
ASN O      O  N N 44  
ASN CB     C  N N 45  
ASN CG     C  N N 46  
ASN OD1    O  N N 47  
ASN ND2    N  N N 48  
ASN OXT    O  N N 49  
ASN H      H  N N 50  
ASN H2     H  N N 51  
ASN HA     H  N N 52  
ASN HB2    H  N N 53  
ASN HB3    H  N N 54  
ASN HD21   H  N N 55  
ASN HD22   H  N N 56  
ASN HXT    H  N N 57  
ASP N      N  N N 58  
ASP CA     C  N S 59  
ASP C      C  N N 60  
ASP O      O  N N 61  
ASP CB     C  N N 62  
ASP CG     C  N N 63  
ASP OD1    O  N N 64  
ASP OD2    O  N N 65  
ASP OXT    O  N N 66  
ASP H      H  N N 67  
ASP H2     H  N N 68  
ASP HA     H  N N 69  
ASP HB2    H  N N 70  
ASP HB3    H  N N 71  
ASP HD2    H  N N 72  
ASP HXT    H  N N 73  
CYS N      N  N N 74  
CYS CA     C  N R 75  
CYS C      C  N N 76  
CYS O      O  N N 77  
CYS CB     C  N N 78  
CYS SG     S  N N 79  
CYS OXT    O  N N 80  
CYS H      H  N N 81  
CYS H2     H  N N 82  
CYS HA     H  N N 83  
CYS HB2    H  N N 84  
CYS HB3    H  N N 85  
CYS HG     H  N N 86  
CYS HXT    H  N N 87  
GLN N      N  N N 88  
GLN CA     C  N S 89  
GLN C      C  N N 90  
GLN O      O  N N 91  
GLN CB     C  N N 92  
GLN CG     C  N N 93  
GLN CD     C  N N 94  
GLN OE1    O  N N 95  
GLN NE2    N  N N 96  
GLN OXT    O  N N 97  
GLN H      H  N N 98  
GLN H2     H  N N 99  
GLN HA     H  N N 100 
GLN HB2    H  N N 101 
GLN HB3    H  N N 102 
GLN HG2    H  N N 103 
GLN HG3    H  N N 104 
GLN HE21   H  N N 105 
GLN HE22   H  N N 106 
GLN HXT    H  N N 107 
GLU N      N  N N 108 
GLU CA     C  N S 109 
GLU C      C  N N 110 
GLU O      O  N N 111 
GLU CB     C  N N 112 
GLU CG     C  N N 113 
GLU CD     C  N N 114 
GLU OE1    O  N N 115 
GLU OE2    O  N N 116 
GLU OXT    O  N N 117 
GLU H      H  N N 118 
GLU H2     H  N N 119 
GLU HA     H  N N 120 
GLU HB2    H  N N 121 
GLU HB3    H  N N 122 
GLU HG2    H  N N 123 
GLU HG3    H  N N 124 
GLU HE2    H  N N 125 
GLU HXT    H  N N 126 
GLY N      N  N N 127 
GLY CA     C  N N 128 
GLY C      C  N N 129 
GLY O      O  N N 130 
GLY OXT    O  N N 131 
GLY H      H  N N 132 
GLY H2     H  N N 133 
GLY HA2    H  N N 134 
GLY HA3    H  N N 135 
GLY HXT    H  N N 136 
HIS N      N  N N 137 
HIS CA     C  N S 138 
HIS C      C  N N 139 
HIS O      O  N N 140 
HIS CB     C  N N 141 
HIS CG     C  Y N 142 
HIS ND1    N  Y N 143 
HIS CD2    C  Y N 144 
HIS CE1    C  Y N 145 
HIS NE2    N  Y N 146 
HIS OXT    O  N N 147 
HIS H      H  N N 148 
HIS H2     H  N N 149 
HIS HA     H  N N 150 
HIS HB2    H  N N 151 
HIS HB3    H  N N 152 
HIS HD1    H  N N 153 
HIS HD2    H  N N 154 
HIS HE1    H  N N 155 
HIS HE2    H  N N 156 
HIS HXT    H  N N 157 
HOH O      O  N N 158 
HOH H1     H  N N 159 
HOH H2     H  N N 160 
ILE N      N  N N 161 
ILE CA     C  N S 162 
ILE C      C  N N 163 
ILE O      O  N N 164 
ILE CB     C  N S 165 
ILE CG1    C  N N 166 
ILE CG2    C  N N 167 
ILE CD1    C  N N 168 
ILE OXT    O  N N 169 
ILE H      H  N N 170 
ILE H2     H  N N 171 
ILE HA     H  N N 172 
ILE HB     H  N N 173 
ILE HG12   H  N N 174 
ILE HG13   H  N N 175 
ILE HG21   H  N N 176 
ILE HG22   H  N N 177 
ILE HG23   H  N N 178 
ILE HD11   H  N N 179 
ILE HD12   H  N N 180 
ILE HD13   H  N N 181 
ILE HXT    H  N N 182 
LEU N      N  N N 183 
LEU CA     C  N S 184 
LEU C      C  N N 185 
LEU O      O  N N 186 
LEU CB     C  N N 187 
LEU CG     C  N N 188 
LEU CD1    C  N N 189 
LEU CD2    C  N N 190 
LEU OXT    O  N N 191 
LEU H      H  N N 192 
LEU H2     H  N N 193 
LEU HA     H  N N 194 
LEU HB2    H  N N 195 
LEU HB3    H  N N 196 
LEU HG     H  N N 197 
LEU HD11   H  N N 198 
LEU HD12   H  N N 199 
LEU HD13   H  N N 200 
LEU HD21   H  N N 201 
LEU HD22   H  N N 202 
LEU HD23   H  N N 203 
LEU HXT    H  N N 204 
LYS N      N  N N 205 
LYS CA     C  N S 206 
LYS C      C  N N 207 
LYS O      O  N N 208 
LYS CB     C  N N 209 
LYS CG     C  N N 210 
LYS CD     C  N N 211 
LYS CE     C  N N 212 
LYS NZ     N  N N 213 
LYS OXT    O  N N 214 
LYS H      H  N N 215 
LYS H2     H  N N 216 
LYS HA     H  N N 217 
LYS HB2    H  N N 218 
LYS HB3    H  N N 219 
LYS HG2    H  N N 220 
LYS HG3    H  N N 221 
LYS HD2    H  N N 222 
LYS HD3    H  N N 223 
LYS HE2    H  N N 224 
LYS HE3    H  N N 225 
LYS HZ1    H  N N 226 
LYS HZ2    H  N N 227 
LYS HZ3    H  N N 228 
LYS HXT    H  N N 229 
MET N      N  N N 230 
MET CA     C  N S 231 
MET C      C  N N 232 
MET O      O  N N 233 
MET CB     C  N N 234 
MET CG     C  N N 235 
MET SD     S  N N 236 
MET CE     C  N N 237 
MET OXT    O  N N 238 
MET H      H  N N 239 
MET H2     H  N N 240 
MET HA     H  N N 241 
MET HB2    H  N N 242 
MET HB3    H  N N 243 
MET HG2    H  N N 244 
MET HG3    H  N N 245 
MET HE1    H  N N 246 
MET HE2    H  N N 247 
MET HE3    H  N N 248 
MET HXT    H  N N 249 
PHE N      N  N N 250 
PHE CA     C  N S 251 
PHE C      C  N N 252 
PHE O      O  N N 253 
PHE CB     C  N N 254 
PHE CG     C  Y N 255 
PHE CD1    C  Y N 256 
PHE CD2    C  Y N 257 
PHE CE1    C  Y N 258 
PHE CE2    C  Y N 259 
PHE CZ     C  Y N 260 
PHE OXT    O  N N 261 
PHE H      H  N N 262 
PHE H2     H  N N 263 
PHE HA     H  N N 264 
PHE HB2    H  N N 265 
PHE HB3    H  N N 266 
PHE HD1    H  N N 267 
PHE HD2    H  N N 268 
PHE HE1    H  N N 269 
PHE HE2    H  N N 270 
PHE HZ     H  N N 271 
PHE HXT    H  N N 272 
PRO N      N  N N 273 
PRO CA     C  N S 274 
PRO C      C  N N 275 
PRO O      O  N N 276 
PRO CB     C  N N 277 
PRO CG     C  N N 278 
PRO CD     C  N N 279 
PRO OXT    O  N N 280 
PRO H      H  N N 281 
PRO HA     H  N N 282 
PRO HB2    H  N N 283 
PRO HB3    H  N N 284 
PRO HG2    H  N N 285 
PRO HG3    H  N N 286 
PRO HD2    H  N N 287 
PRO HD3    H  N N 288 
PRO HXT    H  N N 289 
SAM N      N  N N 290 
SAM CA     C  N S 291 
SAM C      C  N N 292 
SAM O      O  N N 293 
SAM OXT    O  N N 294 
SAM CB     C  N N 295 
SAM CG     C  N N 296 
SAM SD     S  N S 297 
SAM CE     C  N N 298 
SAM "C5'"  C  N N 299 
SAM "C4'"  C  N S 300 
SAM "O4'"  O  N N 301 
SAM "C3'"  C  N S 302 
SAM "O3'"  O  N N 303 
SAM "C2'"  C  N R 304 
SAM "O2'"  O  N N 305 
SAM "C1'"  C  N R 306 
SAM N9     N  Y N 307 
SAM C8     C  Y N 308 
SAM N7     N  Y N 309 
SAM C5     C  Y N 310 
SAM C6     C  Y N 311 
SAM N6     N  N N 312 
SAM N1     N  Y N 313 
SAM C2     C  Y N 314 
SAM N3     N  Y N 315 
SAM C4     C  Y N 316 
SAM HN1    H  N N 317 
SAM HN2    H  N N 318 
SAM HA     H  N N 319 
SAM HB1    H  N N 320 
SAM HB2    H  N N 321 
SAM HG1    H  N N 322 
SAM HG2    H  N N 323 
SAM HE1    H  N N 324 
SAM HE2    H  N N 325 
SAM HE3    H  N N 326 
SAM "H5'1" H  N N 327 
SAM "H5'2" H  N N 328 
SAM "H4'"  H  N N 329 
SAM "H3'"  H  N N 330 
SAM "HO3'" H  N N 331 
SAM "H2'"  H  N N 332 
SAM "HO2'" H  N N 333 
SAM "H1'"  H  N N 334 
SAM H8     H  N N 335 
SAM HN61   H  N N 336 
SAM HN62   H  N N 337 
SAM H2     H  N N 338 
SER N      N  N N 339 
SER CA     C  N S 340 
SER C      C  N N 341 
SER O      O  N N 342 
SER CB     C  N N 343 
SER OG     O  N N 344 
SER OXT    O  N N 345 
SER H      H  N N 346 
SER H2     H  N N 347 
SER HA     H  N N 348 
SER HB2    H  N N 349 
SER HB3    H  N N 350 
SER HG     H  N N 351 
SER HXT    H  N N 352 
THR N      N  N N 353 
THR CA     C  N S 354 
THR C      C  N N 355 
THR O      O  N N 356 
THR CB     C  N R 357 
THR OG1    O  N N 358 
THR CG2    C  N N 359 
THR OXT    O  N N 360 
THR H      H  N N 361 
THR H2     H  N N 362 
THR HA     H  N N 363 
THR HB     H  N N 364 
THR HG1    H  N N 365 
THR HG21   H  N N 366 
THR HG22   H  N N 367 
THR HG23   H  N N 368 
THR HXT    H  N N 369 
TRP N      N  N N 370 
TRP CA     C  N S 371 
TRP C      C  N N 372 
TRP O      O  N N 373 
TRP CB     C  N N 374 
TRP CG     C  Y N 375 
TRP CD1    C  Y N 376 
TRP CD2    C  Y N 377 
TRP NE1    N  Y N 378 
TRP CE2    C  Y N 379 
TRP CE3    C  Y N 380 
TRP CZ2    C  Y N 381 
TRP CZ3    C  Y N 382 
TRP CH2    C  Y N 383 
TRP OXT    O  N N 384 
TRP H      H  N N 385 
TRP H2     H  N N 386 
TRP HA     H  N N 387 
TRP HB2    H  N N 388 
TRP HB3    H  N N 389 
TRP HD1    H  N N 390 
TRP HE1    H  N N 391 
TRP HE3    H  N N 392 
TRP HZ2    H  N N 393 
TRP HZ3    H  N N 394 
TRP HH2    H  N N 395 
TRP HXT    H  N N 396 
TYR N      N  N N 397 
TYR CA     C  N S 398 
TYR C      C  N N 399 
TYR O      O  N N 400 
TYR CB     C  N N 401 
TYR CG     C  Y N 402 
TYR CD1    C  Y N 403 
TYR CD2    C  Y N 404 
TYR CE1    C  Y N 405 
TYR CE2    C  Y N 406 
TYR CZ     C  Y N 407 
TYR OH     O  N N 408 
TYR OXT    O  N N 409 
TYR H      H  N N 410 
TYR H2     H  N N 411 
TYR HA     H  N N 412 
TYR HB2    H  N N 413 
TYR HB3    H  N N 414 
TYR HD1    H  N N 415 
TYR HD2    H  N N 416 
TYR HE1    H  N N 417 
TYR HE2    H  N N 418 
TYR HH     H  N N 419 
TYR HXT    H  N N 420 
VAL N      N  N N 421 
VAL CA     C  N S 422 
VAL C      C  N N 423 
VAL O      O  N N 424 
VAL CB     C  N N 425 
VAL CG1    C  N N 426 
VAL CG2    C  N N 427 
VAL OXT    O  N N 428 
VAL H      H  N N 429 
VAL H2     H  N N 430 
VAL HA     H  N N 431 
VAL HB     H  N N 432 
VAL HG11   H  N N 433 
VAL HG12   H  N N 434 
VAL HG13   H  N N 435 
VAL HG21   H  N N 436 
VAL HG22   H  N N 437 
VAL HG23   H  N N 438 
VAL HXT    H  N N 439 
ZN  ZN     ZN N N 440 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N     CA     sing N N 1   
ALA N     H      sing N N 2   
ALA N     H2     sing N N 3   
ALA CA    C      sing N N 4   
ALA CA    CB     sing N N 5   
ALA CA    HA     sing N N 6   
ALA C     O      doub N N 7   
ALA C     OXT    sing N N 8   
ALA CB    HB1    sing N N 9   
ALA CB    HB2    sing N N 10  
ALA CB    HB3    sing N N 11  
ALA OXT   HXT    sing N N 12  
ARG N     CA     sing N N 13  
ARG N     H      sing N N 14  
ARG N     H2     sing N N 15  
ARG CA    C      sing N N 16  
ARG CA    CB     sing N N 17  
ARG CA    HA     sing N N 18  
ARG C     O      doub N N 19  
ARG C     OXT    sing N N 20  
ARG CB    CG     sing N N 21  
ARG CB    HB2    sing N N 22  
ARG CB    HB3    sing N N 23  
ARG CG    CD     sing N N 24  
ARG CG    HG2    sing N N 25  
ARG CG    HG3    sing N N 26  
ARG CD    NE     sing N N 27  
ARG CD    HD2    sing N N 28  
ARG CD    HD3    sing N N 29  
ARG NE    CZ     sing N N 30  
ARG NE    HE     sing N N 31  
ARG CZ    NH1    sing N N 32  
ARG CZ    NH2    doub N N 33  
ARG NH1   HH11   sing N N 34  
ARG NH1   HH12   sing N N 35  
ARG NH2   HH21   sing N N 36  
ARG NH2   HH22   sing N N 37  
ARG OXT   HXT    sing N N 38  
ASN N     CA     sing N N 39  
ASN N     H      sing N N 40  
ASN N     H2     sing N N 41  
ASN CA    C      sing N N 42  
ASN CA    CB     sing N N 43  
ASN CA    HA     sing N N 44  
ASN C     O      doub N N 45  
ASN C     OXT    sing N N 46  
ASN CB    CG     sing N N 47  
ASN CB    HB2    sing N N 48  
ASN CB    HB3    sing N N 49  
ASN CG    OD1    doub N N 50  
ASN CG    ND2    sing N N 51  
ASN ND2   HD21   sing N N 52  
ASN ND2   HD22   sing N N 53  
ASN OXT   HXT    sing N N 54  
ASP N     CA     sing N N 55  
ASP N     H      sing N N 56  
ASP N     H2     sing N N 57  
ASP CA    C      sing N N 58  
ASP CA    CB     sing N N 59  
ASP CA    HA     sing N N 60  
ASP C     O      doub N N 61  
ASP C     OXT    sing N N 62  
ASP CB    CG     sing N N 63  
ASP CB    HB2    sing N N 64  
ASP CB    HB3    sing N N 65  
ASP CG    OD1    doub N N 66  
ASP CG    OD2    sing N N 67  
ASP OD2   HD2    sing N N 68  
ASP OXT   HXT    sing N N 69  
CYS N     CA     sing N N 70  
CYS N     H      sing N N 71  
CYS N     H2     sing N N 72  
CYS CA    C      sing N N 73  
CYS CA    CB     sing N N 74  
CYS CA    HA     sing N N 75  
CYS C     O      doub N N 76  
CYS C     OXT    sing N N 77  
CYS CB    SG     sing N N 78  
CYS CB    HB2    sing N N 79  
CYS CB    HB3    sing N N 80  
CYS SG    HG     sing N N 81  
CYS OXT   HXT    sing N N 82  
GLN N     CA     sing N N 83  
GLN N     H      sing N N 84  
GLN N     H2     sing N N 85  
GLN CA    C      sing N N 86  
GLN CA    CB     sing N N 87  
GLN CA    HA     sing N N 88  
GLN C     O      doub N N 89  
GLN C     OXT    sing N N 90  
GLN CB    CG     sing N N 91  
GLN CB    HB2    sing N N 92  
GLN CB    HB3    sing N N 93  
GLN CG    CD     sing N N 94  
GLN CG    HG2    sing N N 95  
GLN CG    HG3    sing N N 96  
GLN CD    OE1    doub N N 97  
GLN CD    NE2    sing N N 98  
GLN NE2   HE21   sing N N 99  
GLN NE2   HE22   sing N N 100 
GLN OXT   HXT    sing N N 101 
GLU N     CA     sing N N 102 
GLU N     H      sing N N 103 
GLU N     H2     sing N N 104 
GLU CA    C      sing N N 105 
GLU CA    CB     sing N N 106 
GLU CA    HA     sing N N 107 
GLU C     O      doub N N 108 
GLU C     OXT    sing N N 109 
GLU CB    CG     sing N N 110 
GLU CB    HB2    sing N N 111 
GLU CB    HB3    sing N N 112 
GLU CG    CD     sing N N 113 
GLU CG    HG2    sing N N 114 
GLU CG    HG3    sing N N 115 
GLU CD    OE1    doub N N 116 
GLU CD    OE2    sing N N 117 
GLU OE2   HE2    sing N N 118 
GLU OXT   HXT    sing N N 119 
GLY N     CA     sing N N 120 
GLY N     H      sing N N 121 
GLY N     H2     sing N N 122 
GLY CA    C      sing N N 123 
GLY CA    HA2    sing N N 124 
GLY CA    HA3    sing N N 125 
GLY C     O      doub N N 126 
GLY C     OXT    sing N N 127 
GLY OXT   HXT    sing N N 128 
HIS N     CA     sing N N 129 
HIS N     H      sing N N 130 
HIS N     H2     sing N N 131 
HIS CA    C      sing N N 132 
HIS CA    CB     sing N N 133 
HIS CA    HA     sing N N 134 
HIS C     O      doub N N 135 
HIS C     OXT    sing N N 136 
HIS CB    CG     sing N N 137 
HIS CB    HB2    sing N N 138 
HIS CB    HB3    sing N N 139 
HIS CG    ND1    sing Y N 140 
HIS CG    CD2    doub Y N 141 
HIS ND1   CE1    doub Y N 142 
HIS ND1   HD1    sing N N 143 
HIS CD2   NE2    sing Y N 144 
HIS CD2   HD2    sing N N 145 
HIS CE1   NE2    sing Y N 146 
HIS CE1   HE1    sing N N 147 
HIS NE2   HE2    sing N N 148 
HIS OXT   HXT    sing N N 149 
HOH O     H1     sing N N 150 
HOH O     H2     sing N N 151 
ILE N     CA     sing N N 152 
ILE N     H      sing N N 153 
ILE N     H2     sing N N 154 
ILE CA    C      sing N N 155 
ILE CA    CB     sing N N 156 
ILE CA    HA     sing N N 157 
ILE C     O      doub N N 158 
ILE C     OXT    sing N N 159 
ILE CB    CG1    sing N N 160 
ILE CB    CG2    sing N N 161 
ILE CB    HB     sing N N 162 
ILE CG1   CD1    sing N N 163 
ILE CG1   HG12   sing N N 164 
ILE CG1   HG13   sing N N 165 
ILE CG2   HG21   sing N N 166 
ILE CG2   HG22   sing N N 167 
ILE CG2   HG23   sing N N 168 
ILE CD1   HD11   sing N N 169 
ILE CD1   HD12   sing N N 170 
ILE CD1   HD13   sing N N 171 
ILE OXT   HXT    sing N N 172 
LEU N     CA     sing N N 173 
LEU N     H      sing N N 174 
LEU N     H2     sing N N 175 
LEU CA    C      sing N N 176 
LEU CA    CB     sing N N 177 
LEU CA    HA     sing N N 178 
LEU C     O      doub N N 179 
LEU C     OXT    sing N N 180 
LEU CB    CG     sing N N 181 
LEU CB    HB2    sing N N 182 
LEU CB    HB3    sing N N 183 
LEU CG    CD1    sing N N 184 
LEU CG    CD2    sing N N 185 
LEU CG    HG     sing N N 186 
LEU CD1   HD11   sing N N 187 
LEU CD1   HD12   sing N N 188 
LEU CD1   HD13   sing N N 189 
LEU CD2   HD21   sing N N 190 
LEU CD2   HD22   sing N N 191 
LEU CD2   HD23   sing N N 192 
LEU OXT   HXT    sing N N 193 
LYS N     CA     sing N N 194 
LYS N     H      sing N N 195 
LYS N     H2     sing N N 196 
LYS CA    C      sing N N 197 
LYS CA    CB     sing N N 198 
LYS CA    HA     sing N N 199 
LYS C     O      doub N N 200 
LYS C     OXT    sing N N 201 
LYS CB    CG     sing N N 202 
LYS CB    HB2    sing N N 203 
LYS CB    HB3    sing N N 204 
LYS CG    CD     sing N N 205 
LYS CG    HG2    sing N N 206 
LYS CG    HG3    sing N N 207 
LYS CD    CE     sing N N 208 
LYS CD    HD2    sing N N 209 
LYS CD    HD3    sing N N 210 
LYS CE    NZ     sing N N 211 
LYS CE    HE2    sing N N 212 
LYS CE    HE3    sing N N 213 
LYS NZ    HZ1    sing N N 214 
LYS NZ    HZ2    sing N N 215 
LYS NZ    HZ3    sing N N 216 
LYS OXT   HXT    sing N N 217 
MET N     CA     sing N N 218 
MET N     H      sing N N 219 
MET N     H2     sing N N 220 
MET CA    C      sing N N 221 
MET CA    CB     sing N N 222 
MET CA    HA     sing N N 223 
MET C     O      doub N N 224 
MET C     OXT    sing N N 225 
MET CB    CG     sing N N 226 
MET CB    HB2    sing N N 227 
MET CB    HB3    sing N N 228 
MET CG    SD     sing N N 229 
MET CG    HG2    sing N N 230 
MET CG    HG3    sing N N 231 
MET SD    CE     sing N N 232 
MET CE    HE1    sing N N 233 
MET CE    HE2    sing N N 234 
MET CE    HE3    sing N N 235 
MET OXT   HXT    sing N N 236 
PHE N     CA     sing N N 237 
PHE N     H      sing N N 238 
PHE N     H2     sing N N 239 
PHE CA    C      sing N N 240 
PHE CA    CB     sing N N 241 
PHE CA    HA     sing N N 242 
PHE C     O      doub N N 243 
PHE C     OXT    sing N N 244 
PHE CB    CG     sing N N 245 
PHE CB    HB2    sing N N 246 
PHE CB    HB3    sing N N 247 
PHE CG    CD1    doub Y N 248 
PHE CG    CD2    sing Y N 249 
PHE CD1   CE1    sing Y N 250 
PHE CD1   HD1    sing N N 251 
PHE CD2   CE2    doub Y N 252 
PHE CD2   HD2    sing N N 253 
PHE CE1   CZ     doub Y N 254 
PHE CE1   HE1    sing N N 255 
PHE CE2   CZ     sing Y N 256 
PHE CE2   HE2    sing N N 257 
PHE CZ    HZ     sing N N 258 
PHE OXT   HXT    sing N N 259 
PRO N     CA     sing N N 260 
PRO N     CD     sing N N 261 
PRO N     H      sing N N 262 
PRO CA    C      sing N N 263 
PRO CA    CB     sing N N 264 
PRO CA    HA     sing N N 265 
PRO C     O      doub N N 266 
PRO C     OXT    sing N N 267 
PRO CB    CG     sing N N 268 
PRO CB    HB2    sing N N 269 
PRO CB    HB3    sing N N 270 
PRO CG    CD     sing N N 271 
PRO CG    HG2    sing N N 272 
PRO CG    HG3    sing N N 273 
PRO CD    HD2    sing N N 274 
PRO CD    HD3    sing N N 275 
PRO OXT   HXT    sing N N 276 
SAM N     CA     sing N N 277 
SAM N     HN1    sing N N 278 
SAM N     HN2    sing N N 279 
SAM CA    C      sing N N 280 
SAM CA    CB     sing N N 281 
SAM CA    HA     sing N N 282 
SAM C     O      doub N N 283 
SAM C     OXT    sing N N 284 
SAM CB    CG     sing N N 285 
SAM CB    HB1    sing N N 286 
SAM CB    HB2    sing N N 287 
SAM CG    SD     sing N N 288 
SAM CG    HG1    sing N N 289 
SAM CG    HG2    sing N N 290 
SAM SD    CE     sing N N 291 
SAM SD    "C5'"  sing N N 292 
SAM CE    HE1    sing N N 293 
SAM CE    HE2    sing N N 294 
SAM CE    HE3    sing N N 295 
SAM "C5'" "C4'"  sing N N 296 
SAM "C5'" "H5'1" sing N N 297 
SAM "C5'" "H5'2" sing N N 298 
SAM "C4'" "O4'"  sing N N 299 
SAM "C4'" "C3'"  sing N N 300 
SAM "C4'" "H4'"  sing N N 301 
SAM "O4'" "C1'"  sing N N 302 
SAM "C3'" "O3'"  sing N N 303 
SAM "C3'" "C2'"  sing N N 304 
SAM "C3'" "H3'"  sing N N 305 
SAM "O3'" "HO3'" sing N N 306 
SAM "C2'" "O2'"  sing N N 307 
SAM "C2'" "C1'"  sing N N 308 
SAM "C2'" "H2'"  sing N N 309 
SAM "O2'" "HO2'" sing N N 310 
SAM "C1'" N9     sing N N 311 
SAM "C1'" "H1'"  sing N N 312 
SAM N9    C8     sing Y N 313 
SAM N9    C4     sing Y N 314 
SAM C8    N7     doub Y N 315 
SAM C8    H8     sing N N 316 
SAM N7    C5     sing Y N 317 
SAM C5    C6     sing Y N 318 
SAM C5    C4     doub Y N 319 
SAM C6    N6     sing N N 320 
SAM C6    N1     doub Y N 321 
SAM N6    HN61   sing N N 322 
SAM N6    HN62   sing N N 323 
SAM N1    C2     sing Y N 324 
SAM C2    N3     doub Y N 325 
SAM C2    H2     sing N N 326 
SAM N3    C4     sing Y N 327 
SER N     CA     sing N N 328 
SER N     H      sing N N 329 
SER N     H2     sing N N 330 
SER CA    C      sing N N 331 
SER CA    CB     sing N N 332 
SER CA    HA     sing N N 333 
SER C     O      doub N N 334 
SER C     OXT    sing N N 335 
SER CB    OG     sing N N 336 
SER CB    HB2    sing N N 337 
SER CB    HB3    sing N N 338 
SER OG    HG     sing N N 339 
SER OXT   HXT    sing N N 340 
THR N     CA     sing N N 341 
THR N     H      sing N N 342 
THR N     H2     sing N N 343 
THR CA    C      sing N N 344 
THR CA    CB     sing N N 345 
THR CA    HA     sing N N 346 
THR C     O      doub N N 347 
THR C     OXT    sing N N 348 
THR CB    OG1    sing N N 349 
THR CB    CG2    sing N N 350 
THR CB    HB     sing N N 351 
THR OG1   HG1    sing N N 352 
THR CG2   HG21   sing N N 353 
THR CG2   HG22   sing N N 354 
THR CG2   HG23   sing N N 355 
THR OXT   HXT    sing N N 356 
TRP N     CA     sing N N 357 
TRP N     H      sing N N 358 
TRP N     H2     sing N N 359 
TRP CA    C      sing N N 360 
TRP CA    CB     sing N N 361 
TRP CA    HA     sing N N 362 
TRP C     O      doub N N 363 
TRP C     OXT    sing N N 364 
TRP CB    CG     sing N N 365 
TRP CB    HB2    sing N N 366 
TRP CB    HB3    sing N N 367 
TRP CG    CD1    doub Y N 368 
TRP CG    CD2    sing Y N 369 
TRP CD1   NE1    sing Y N 370 
TRP CD1   HD1    sing N N 371 
TRP CD2   CE2    doub Y N 372 
TRP CD2   CE3    sing Y N 373 
TRP NE1   CE2    sing Y N 374 
TRP NE1   HE1    sing N N 375 
TRP CE2   CZ2    sing Y N 376 
TRP CE3   CZ3    doub Y N 377 
TRP CE3   HE3    sing N N 378 
TRP CZ2   CH2    doub Y N 379 
TRP CZ2   HZ2    sing N N 380 
TRP CZ3   CH2    sing Y N 381 
TRP CZ3   HZ3    sing N N 382 
TRP CH2   HH2    sing N N 383 
TRP OXT   HXT    sing N N 384 
TYR N     CA     sing N N 385 
TYR N     H      sing N N 386 
TYR N     H2     sing N N 387 
TYR CA    C      sing N N 388 
TYR CA    CB     sing N N 389 
TYR CA    HA     sing N N 390 
TYR C     O      doub N N 391 
TYR C     OXT    sing N N 392 
TYR CB    CG     sing N N 393 
TYR CB    HB2    sing N N 394 
TYR CB    HB3    sing N N 395 
TYR CG    CD1    doub Y N 396 
TYR CG    CD2    sing Y N 397 
TYR CD1   CE1    sing Y N 398 
TYR CD1   HD1    sing N N 399 
TYR CD2   CE2    doub Y N 400 
TYR CD2   HD2    sing N N 401 
TYR CE1   CZ     doub Y N 402 
TYR CE1   HE1    sing N N 403 
TYR CE2   CZ     sing Y N 404 
TYR CE2   HE2    sing N N 405 
TYR CZ    OH     sing N N 406 
TYR OH    HH     sing N N 407 
TYR OXT   HXT    sing N N 408 
VAL N     CA     sing N N 409 
VAL N     H      sing N N 410 
VAL N     H2     sing N N 411 
VAL CA    C      sing N N 412 
VAL CA    CB     sing N N 413 
VAL CA    HA     sing N N 414 
VAL C     O      doub N N 415 
VAL C     OXT    sing N N 416 
VAL CB    CG1    sing N N 417 
VAL CB    CG2    sing N N 418 
VAL CB    HB     sing N N 419 
VAL CG1   HG11   sing N N 420 
VAL CG1   HG12   sing N N 421 
VAL CG1   HG13   sing N N 422 
VAL CG2   HG21   sing N N 423 
VAL CG2   HG22   sing N N 424 
VAL CG2   HG23   sing N N 425 
VAL OXT   HXT    sing N N 426 
# 
_pdbx_audit_support.funding_organization   'Other government' 
_pdbx_audit_support.country                France 
_pdbx_audit_support.grant_number           'PhD fellowship from University Paris Cite' 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   8Q5P 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 21 21 21' 
_space_group.name_Hall        'P 2ac 2ab' 
_space_group.IT_number        19 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8RZU 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.016745 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.012919 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.012840 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C    ? ? 3.54356  2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N    ? ? 4.01032  2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O    ? ? 4.49882  3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S    ? ? 9.55732  6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
ZN   ? ? ?        ?       ? ? ?        ?        ? ? ?   ? ? 
ZN2+ ? ? 27.87530 ?       ? ? 3.31736  ?        ? ? 0.0 
;1-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N     . PRO A 1 31  ? 8.48800  13.49400  -6.33000  1.000 86.44774  ? 1447 PRO A N     1 
ATOM   2    C  CA    . PRO A 1 31  ? 7.92500  12.72200  -5.22000  1.000 89.97245  ? 1447 PRO A CA    1 
ATOM   3    C  C     . PRO A 1 31  ? 9.01200  12.03700  -4.41000  1.000 88.82793  ? 1447 PRO A C     1 
ATOM   4    O  O     . PRO A 1 31  ? 9.86800  11.35600  -4.97800  1.000 82.22451  ? 1447 PRO A O     1 
ATOM   5    C  CB    . PRO A 1 31  ? 7.03000  11.68600  -5.91500  1.000 80.89712  ? 1447 PRO A CB    1 
ATOM   6    C  CG    . PRO A 1 31  ? 6.92500  12.14600  -7.34300  1.000 86.88822  ? 1447 PRO A CG    1 
ATOM   7    C  CD    . PRO A 1 31  ? 8.21900  12.83900  -7.61500  1.000 89.10825  ? 1447 PRO A CD    1 
ATOM   8    N  N     . SER A 1 32  ? 8.94900  12.23000  -3.09400  1.000 95.06026  ? 1448 SER A N     1 
ATOM   9    C  CA    . SER A 1 32  ? 9.94300  11.75500  -2.14400  1.000 90.58867  ? 1448 SER A CA    1 
ATOM   10   C  C     . SER A 1 32  ? 9.26200  11.60200  -0.79000  1.000 90.52519  ? 1448 SER A C     1 
ATOM   11   O  O     . SER A 1 32  ? 8.32800  12.34600  -0.47100  1.000 91.02557  ? 1448 SER A O     1 
ATOM   12   C  CB    . SER A 1 32  ? 11.13000 12.72800  -2.06300  1.000 90.03071  ? 1448 SER A CB    1 
ATOM   13   O  OG    . SER A 1 32  ? 11.70100 12.74900  -0.76700  1.000 92.88895  ? 1448 SER A OG    1 
ATOM   14   N  N     . CYS A 1 33  ? 9.71700  10.62500  0.00100   1.000 81.72531  ? 1449 CYS A N     1 
ATOM   15   C  CA    . CYS A 1 33  ? 9.12100  10.40800  1.31500   1.000 84.39551  ? 1449 CYS A CA    1 
ATOM   16   C  C     . CYS A 1 33  ? 10.08600 9.65400   2.22100   1.000 84.01157  ? 1449 CYS A C     1 
ATOM   17   O  O     . CYS A 1 33  ? 10.66200 8.63900   1.81600   1.000 77.03705  ? 1449 CYS A O     1 
ATOM   18   C  CB    . CYS A 1 33  ? 7.79400  9.65300   1.20500   1.000 79.93709  ? 1449 CYS A CB    1 
ATOM   19   S  SG    . CYS A 1 33  ? 7.75500  8.42800   -0.08600  1.000 86.70926  ? 1449 CYS A SG    1 
ATOM   20   N  N     . VAL A 1 34  ? 10.23400 10.14800  3.45400   1.000 84.42797  ? 1450 VAL A N     1 
ATOM   21   C  CA    . VAL A 1 34  ? 11.18100 9.60800   4.42100   1.000 82.90261  ? 1450 VAL A CA    1 
ATOM   22   C  C     . VAL A 1 34  ? 10.60500 8.33400   5.02400   1.000 83.10277  ? 1450 VAL A C     1 
ATOM   23   O  O     . VAL A 1 34  ? 9.41000  8.05700   4.88600   1.000 81.21167  ? 1450 VAL A O     1 
ATOM   24   C  CB    . VAL A 1 34  ? 11.50100 10.64300  5.51400   1.000 88.75766  ? 1450 VAL A CB    1 
ATOM   25   C  CG1   . VAL A 1 34  ? 12.24500 11.83600  4.91800   1.000 86.83025  ? 1450 VAL A CG1   1 
ATOM   26   C  CG2   . VAL A 1 34  ? 10.22000 11.09400  6.19700   1.000 88.44894  ? 1450 VAL A CG2   1 
ATOM   27   N  N     . MET A 1 35  ? 11.44300 7.56400   5.72100   1.000 83.88139  ? 1451 MET A N     1 
ATOM   28   C  CA    . MET A 1 35  ? 11.01300 6.25300   6.19300   1.000 86.15130  ? 1451 MET A CA    1 
ATOM   29   C  C     . MET A 1 35  ? 9.99200  6.31600   7.32500   1.000 84.39582  ? 1451 MET A C     1 
ATOM   30   O  O     . MET A 1 35  ? 9.23500  5.35600   7.50600   1.000 78.97475  ? 1451 MET A O     1 
ATOM   31   C  CB    . MET A 1 35  ? 12.21000 5.43000   6.64300   1.000 91.70481  ? 1451 MET A CB    1 
ATOM   32   C  CG    . MET A 1 35  ? 12.84600 4.62400   5.52500   1.000 90.78343  ? 1451 MET A CG    1 
ATOM   33   S  SD    . MET A 1 35  ? 14.51800 4.16700   5.99500   1.000 106.00631 ? 1451 MET A SD    1 
ATOM   34   C  CE    . MET A 1 35  ? 14.32600 3.84000   7.75800   1.000 104.48507 ? 1451 MET A CE    1 
ATOM   35   N  N     . ASP A 1 36  ? 9.95200  7.39800   8.10300   1.000 86.89785  ? 1452 ASP A N     1 
ATOM   36   C  CA    . ASP A 1 36  ? 8.88500  7.50600   9.09100   1.000 86.08952  ? 1452 ASP A CA    1 
ATOM   37   C  C     . ASP A 1 36  ? 7.52800  7.85800   8.47600   1.000 85.21961  ? 1452 ASP A C     1 
ATOM   38   O  O     . ASP A 1 36  ? 6.53200  7.92000   9.21000   1.000 87.38302  ? 1452 ASP A O     1 
ATOM   39   C  CB    . ASP A 1 36  ? 9.24500  8.54600   10.16700  1.000 94.28257  ? 1452 ASP A CB    1 
ATOM   40   C  CG    . ASP A 1 36  ? 10.49300 8.16900   10.99200  1.000 90.32812  ? 1452 ASP A CG    1 
ATOM   41   O  OD1   . ASP A 1 36  ? 10.81700 6.95600   11.08400  1.000 90.44655  ? 1452 ASP A OD1   1 
ATOM   42   O  OD2   . ASP A 1 36  ? 11.11300 9.06900   11.59000  1.000 87.08527  ? 1452 ASP A OD2   1 
ATOM   43   N  N     . ASP A 1 37  ? 7.45400  8.06700   7.15400   1.000 78.31540  ? 1453 ASP A N     1 
ATOM   44   C  CA    . ASP A 1 37  ? 6.15300  8.21900   6.51200   1.000 75.50009  ? 1453 ASP A CA    1 
ATOM   45   C  C     . ASP A 1 37  ? 5.40800  6.88900   6.43400   1.000 68.65248  ? 1453 ASP A C     1 
ATOM   46   O  O     . ASP A 1 37  ? 4.17100  6.86200   6.45100   1.000 68.94593  ? 1453 ASP A O     1 
ATOM   47   C  CB    . ASP A 1 37  ? 6.31700  8.81600   5.11000   1.000 82.77685  ? 1453 ASP A CB    1 
ATOM   48   C  CG    . ASP A 1 37  ? 6.73100  10.27700  5.13900   1.000 85.06264  ? 1453 ASP A CG    1 
ATOM   49   O  OD1   . ASP A 1 37  ? 6.25800  11.00100  6.03500   1.000 90.51540  ? 1453 ASP A OD1   1 
ATOM   50   O  OD2   . ASP A 1 37  ? 7.51800  10.70600  4.26400   1.000 80.46575  ? 1453 ASP A OD2   1 
ATOM   51   N  N     . PHE A 1 38  ? 6.14000  5.78600   6.37100   1.000 61.45850  ? 1454 PHE A N     1 
ATOM   52   C  CA    . PHE A 1 38  ? 5.55400  4.46100   6.32300   1.000 62.95983  ? 1454 PHE A CA    1 
ATOM   53   C  C     . PHE A 1 38  ? 5.09300  3.94200   7.68900   1.000 70.12364  ? 1454 PHE A C     1 
ATOM   54   O  O     . PHE A 1 38  ? 4.80800  2.74700   7.80300   1.000 58.87094  ? 1454 PHE A O     1 
ATOM   55   C  CB    . PHE A 1 38  ? 6.56100  3.47800   5.72100   1.000 61.19374  ? 1454 PHE A CB    1 
ATOM   56   C  CG    . PHE A 1 38  ? 7.01300  3.84400   4.32400   1.000 58.03104  ? 1454 PHE A CG    1 
ATOM   57   C  CD1   . PHE A 1 38  ? 8.00900  4.78500   4.12100   1.000 59.93667  ? 1454 PHE A CD1   1 
ATOM   58   C  CD2   . PHE A 1 38  ? 6.42800  3.25300   3.22500   1.000 56.74377  ? 1454 PHE A CD2   1 
ATOM   59   C  CE1   . PHE A 1 38  ? 8.41500  5.12400   2.85800   1.000 64.50884  ? 1454 PHE A CE1   1 
ATOM   60   C  CE2   . PHE A 1 38  ? 6.82700  3.58900   1.94700   1.000 56.36869  ? 1454 PHE A CE2   1 
ATOM   61   C  CZ    . PHE A 1 38  ? 7.82600  4.52100   1.76300   1.000 56.29261  ? 1454 PHE A CZ    1 
ATOM   62   N  N     . ARG A 1 39  ? 5.00300  4.77200   8.73100   1.000 70.14245  ? 1455 ARG A N     1 
ATOM   63   C  CA    . ARG A 1 39  ? 4.56100  4.21600   10.00600  1.000 73.67824  ? 1455 ARG A CA    1 
ATOM   64   C  C     . ARG A 1 39  ? 3.06600  4.35800   10.22600  1.000 73.60988  ? 1455 ARG A C     1 
ATOM   65   O  O     . ARG A 1 39  ? 2.47100  3.51600   10.90400  1.000 72.72867  ? 1455 ARG A O     1 
ATOM   66   C  CB    . ARG A 1 39  ? 5.31700  4.86600   11.16800  1.000 74.80621  ? 1455 ARG A CB    1 
ATOM   67   C  CG    . ARG A 1 39  ? 6.81700  4.88100   10.95400  1.000 80.04850  ? 1455 ARG A CG    1 
ATOM   68   C  CD    . ARG A 1 39  ? 7.50800  5.78300   11.95700  1.000 92.93753  ? 1455 ARG A CD    1 
ATOM   69   N  NE    . ARG A 1 39  ? 6.88100  5.72900   13.27300  1.000 97.66092  ? 1455 ARG A NE    1 
ATOM   70   C  CZ    . ARG A 1 39  ? 7.03000  6.65900   14.21200  1.000 97.93692  ? 1455 ARG A CZ    1 
ATOM   71   N  NH1   . ARG A 1 39  ? 7.78100  7.73100   13.98400  1.000 96.86048  ? 1455 ARG A NH1   1 
ATOM   72   N  NH2   . ARG A 1 39  ? 6.42500  6.51500   15.38300  1.000 100.03717 ? 1455 ARG A NH2   1 
ATOM   73   N  N     . ASP A 1 40  ? 2.45000  5.40000   9.67500   1.000 76.65016  ? 1456 ASP A N     1 
ATOM   74   C  CA    . ASP A 1 40  ? 1.01400  5.62200   9.77500   1.000 79.53487  ? 1456 ASP A CA    1 
ATOM   75   C  C     . ASP A 1 40  ? 0.34000  4.97700   8.57000   1.000 81.34809  ? 1456 ASP A C     1 
ATOM   76   O  O     . ASP A 1 40  ? 0.28100  5.59000   7.49500   1.000 79.31627  ? 1456 ASP A O     1 
ATOM   77   C  CB    . ASP A 1 40  ? 0.70600  7.12000   9.84000   1.000 82.56870  ? 1456 ASP A CB    1 
ATOM   78   C  CG    . ASP A 1 40  ? -0.76100 7.40800   10.07600  1.000 93.65746  ? 1456 ASP A CG    1 
ATOM   79   O  OD1   . ASP A 1 40  ? -1.57100 6.45700   10.09300  1.000 94.28385  ? 1456 ASP A OD1   1 
ATOM   80   O  OD2   . ASP A 1 40  ? -1.10700 8.59700   10.25700  1.000 105.87471 ? 1456 ASP A OD2   1 
ATOM   81   N  N     . PRO A 1 41  ? -0.19100 3.75900   8.70500   1.000 73.14396  ? 1457 PRO A N     1 
ATOM   82   C  CA    . PRO A 1 41  ? -0.74000 3.08200   7.52500   1.000 76.34327  ? 1457 PRO A CA    1 
ATOM   83   C  C     . PRO A 1 41  ? -1.94200 3.78700   6.93000   1.000 78.75421  ? 1457 PRO A C     1 
ATOM   84   O  O     . PRO A 1 41  ? -2.13700 3.71000   5.71100   1.000 73.80675  ? 1457 PRO A O     1 
ATOM   85   C  CB    . PRO A 1 41  ? -1.09800 1.68300   8.05400   1.000 71.59834  ? 1457 PRO A CB    1 
ATOM   86   C  CG    . PRO A 1 41  ? -0.35700 1.56000   9.34500   1.000 76.21585  ? 1457 PRO A CG    1 
ATOM   87   C  CD    . PRO A 1 41  ? -0.35400 2.93900   9.91100   1.000 76.58056  ? 1457 PRO A CD    1 
ATOM   88   N  N     . GLN A 1 42  ? -2.74800 4.49000   7.72700   1.000 78.81220  ? 1458 GLN A N     1 
ATOM   89   C  CA    . GLN A 1 42  ? -3.87100 5.20000   7.12300   1.000 82.10509  ? 1458 GLN A CA    1 
ATOM   90   C  C     . GLN A 1 42  ? -3.39800 6.41300   6.33300   1.000 80.61663  ? 1458 GLN A C     1 
ATOM   91   O  O     . GLN A 1 42  ? -3.87900 6.66100   5.22000   1.000 82.02712  ? 1458 GLN A O     1 
ATOM   92   C  CB    . GLN A 1 42  ? -4.89100 5.62600   8.17400   1.000 88.72003  ? 1458 GLN A CB    1 
ATOM   93   C  CG    . GLN A 1 42  ? -6.09600 6.30400   7.52500   1.000 96.69290  ? 1458 GLN A CG    1 
ATOM   94   C  CD    . GLN A 1 42  ? -7.14200 6.75800   8.52200   1.000 114.52800 ? 1458 GLN A CD    1 
ATOM   95   O  OE1   . GLN A 1 42  ? -7.51900 6.01100   9.42800   1.000 120.72272 ? 1458 GLN A OE1   1 
ATOM   96   N  NE2   . GLN A 1 42  ? -7.63200 7.98500   8.34900   1.000 119.20393 ? 1458 GLN A NE2   1 
ATOM   97   N  N     . ARG A 1 43  ? -2.47300 7.19400   6.89600   1.000 79.60043  ? 1459 ARG A N     1 
ATOM   98   C  CA    . ARG A 1 43  ? -1.91800 8.31800   6.15000   1.000 82.69722  ? 1459 ARG A CA    1 
ATOM   99   C  C     . ARG A 1 43  ? -1.11500 7.82700   4.95400   1.000 79.86319  ? 1459 ARG A C     1 
ATOM   100  O  O     . ARG A 1 43  ? -1.19500 8.40000   3.85900   1.000 74.53498  ? 1459 ARG A O     1 
ATOM   101  C  CB    . ARG A 1 43  ? -1.05600 9.18100   7.07000   1.000 88.93321  ? 1459 ARG A CB    1 
ATOM   102  C  CG    . ARG A 1 43  ? -0.31600 10.29800  6.36300   1.000 104.49034 ? 1459 ARG A CG    1 
ATOM   103  C  CD    . ARG A 1 43  ? 1.08300  10.43800  6.91800   1.000 115.90486 ? 1459 ARG A CD    1 
ATOM   104  N  NE    . ARG A 1 43  ? 1.84400  11.50000  6.26600   1.000 122.77411 ? 1459 ARG A NE    1 
ATOM   105  C  CZ    . ARG A 1 43  ? 3.11900  11.37400  5.91900   1.000 121.88190 ? 1459 ARG A CZ    1 
ATOM   106  N  NH1   . ARG A 1 43  ? 3.74500  10.23400  6.16400   1.000 121.21603 ? 1459 ARG A NH1   1 
ATOM   107  N  NH2   . ARG A 1 43  ? 3.76300  12.37400  5.33000   1.000 119.60004 ? 1459 ARG A NH2   1 
ATOM   108  N  N     . TRP A 1 44  ? -0.33700 6.76400   5.15000   1.000 75.89841  ? 1460 TRP A N     1 
ATOM   109  C  CA    . TRP A 1 44  ? 0.38500  6.15200   4.04800   1.000 70.42710  ? 1460 TRP A CA    1 
ATOM   110  C  C     . TRP A 1 44  ? -0.57600 5.70900   2.94900   1.000 69.07615  ? 1460 TRP A C     1 
ATOM   111  O  O     . TRP A 1 44  ? -0.39700 6.06200   1.77900   1.000 67.96185  ? 1460 TRP A O     1 
ATOM   112  C  CB    . TRP A 1 44  ? 1.20500  4.98000   4.57400   1.000 64.16296  ? 1460 TRP A CB    1 
ATOM   113  C  CG    . TRP A 1 44  ? 1.90200  4.14600   3.53400   1.000 64.58631  ? 1460 TRP A CG    1 
ATOM   114  C  CD1   . TRP A 1 44  ? 2.01600  4.40100   2.18500   1.000 60.45859  ? 1460 TRP A CD1   1 
ATOM   115  C  CD2   . TRP A 1 44  ? 2.59400  2.91600   3.76700   1.000 61.08456  ? 1460 TRP A CD2   1 
ATOM   116  N  NE1   . TRP A 1 44  ? 2.73600  3.40000   1.57800   1.000 57.32695  ? 1460 TRP A NE1   1 
ATOM   117  C  CE2   . TRP A 1 44  ? 3.10500  2.47700   2.52000   1.000 56.82460  ? 1460 TRP A CE2   1 
ATOM   118  C  CE3   . TRP A 1 44  ? 2.83900  2.14400   4.91200   1.000 55.12415  ? 1460 TRP A CE3   1 
ATOM   119  C  CZ2   . TRP A 1 44  ? 3.83100  1.29700   2.38200   1.000 55.63109  ? 1460 TRP A CZ2   1 
ATOM   120  C  CZ3   . TRP A 1 44  ? 3.56300  0.97600   4.78000   1.000 57.99008  ? 1460 TRP A CZ3   1 
ATOM   121  C  CH2   . TRP A 1 44  ? 4.05500  0.56100   3.51600   1.000 54.08436  ? 1460 TRP A CH2   1 
ATOM   122  N  N     . LYS A 1 45  ? -1.60800 4.94100   3.30900   1.000 67.71488  ? 1461 LYS A N     1 
ATOM   123  C  CA    . LYS A 1 45  ? -2.55600 4.46600   2.30700   1.000 69.43757  ? 1461 LYS A CA    1 
ATOM   124  C  C     . LYS A 1 45  ? -3.17800 5.62600   1.54100   1.000 74.26201  ? 1461 LYS A C     1 
ATOM   125  O  O     . LYS A 1 45  ? -3.35000 5.55000   0.31900   1.000 73.42283  ? 1461 LYS A O     1 
ATOM   126  C  CB    . LYS A 1 45  ? -3.64800 3.61500   2.96100   1.000 72.53145  ? 1461 LYS A CB    1 
ATOM   127  C  CG    . LYS A 1 45  ? -3.31700 2.11800   3.08700   1.000 71.96775  ? 1461 LYS A CG    1 
ATOM   128  C  CD    . LYS A 1 45  ? -4.17500 1.43200   4.16500   1.000 70.74845  ? 1461 LYS A CD    1 
ATOM   129  C  CE    . LYS A 1 45  ? -3.92000 -0.07400  4.22500   1.000 70.29567  ? 1461 LYS A CE    1 
ATOM   130  N  NZ    . LYS A 1 45  ? -4.35200 -0.69300  5.51700   1.000 78.77060  ? 1461 LYS A NZ    1 
ATOM   131  N  N     . GLU A 1 46  ? -3.51000 6.71700   2.23600   1.000 77.39844  ? 1462 GLU A N     1 
ATOM   132  C  CA    . GLU A 1 46  ? -4.15700 7.83200   1.54900   1.000 80.66042  ? 1462 GLU A CA    1 
ATOM   133  C  C     . GLU A 1 46  ? -3.16700 8.59400   0.68000   1.000 75.81986  ? 1462 GLU A C     1 
ATOM   134  O  O     . GLU A 1 46  ? -3.51500 9.03500   -0.41900  1.000 81.84526  ? 1462 GLU A O     1 
ATOM   135  C  CB    . GLU A 1 46  ? -4.83600 8.77000   2.54900   1.000 90.02521  ? 1462 GLU A CB    1 
ATOM   136  C  CG    . GLU A 1 46  ? -5.93000 9.61300   1.90700   1.000 101.63099 ? 1462 GLU A CG    1 
ATOM   137  C  CD    . GLU A 1 46  ? -5.84600 11.07900  2.28700   1.000 114.98897 ? 1462 GLU A CD    1 
ATOM   138  O  OE1   . GLU A 1 46  ? -4.73800 11.54500  2.63100   1.000 120.75018 ? 1462 GLU A OE1   1 
ATOM   139  O  OE2   . GLU A 1 46  ? -6.89100 11.76500  2.25200   1.000 118.78542 ? 1462 GLU A OE2   1 
ATOM   140  N  N     . CYS A 1 47  ? -1.93000 8.75900   1.15400   1.000 71.28516  ? 1463 CYS A N     1 
ATOM   141  C  CA    . CYS A 1 47  ? -0.88700 9.34700   0.31900   1.000 69.17027  ? 1463 CYS A CA    1 
ATOM   142  C  C     . CYS A 1 47  ? -0.66400 8.51200   -0.93700  1.000 71.58238  ? 1463 CYS A C     1 
ATOM   143  O  O     . CYS A 1 47  ? -0.40500 9.05500   -2.01900  1.000 70.09428  ? 1463 CYS A O     1 
ATOM   144  C  CB    . CYS A 1 47  ? 0.42300  9.44800   1.09800   1.000 69.90976  ? 1463 CYS A CB    1 
ATOM   145  S  SG    . CYS A 1 47  ? 0.71600  10.99300  1.99400   1.000 72.38123  ? 1463 CYS A SG    1 
ATOM   146  N  N     . ALA A 1 48  ? -0.75300 7.18100   -0.81100  1.000 67.12001  ? 1464 ALA A N     1 
ATOM   147  C  CA    . ALA A 1 48  ? -0.56800 6.30700   -1.96300  1.000 70.08531  ? 1464 ALA A CA    1 
ATOM   148  C  C     . ALA A 1 48  ? -1.68400 6.49300   -2.97200  1.000 72.26147  ? 1464 ALA A C     1 
ATOM   149  O  O     . ALA A 1 48  ? -1.42900 6.52800   -4.18000  1.000 67.11530  ? 1464 ALA A O     1 
ATOM   150  C  CB    . ALA A 1 48  ? -0.49200 4.85100   -1.51800  1.000 61.64256  ? 1464 ALA A CB    1 
ATOM   151  N  N     . LYS A 1 49  ? -2.92800 6.61300   -2.50100  1.000 75.37259  ? 1465 LYS A N     1 
ATOM   152  C  CA    . LYS A 1 49  ? -4.02200 6.88500   -3.42600  1.000 77.35436  ? 1465 LYS A CA    1 
ATOM   153  C  C     . LYS A 1 49  ? -3.77200 8.16600   -4.21700  1.000 76.03666  ? 1465 LYS A C     1 
ATOM   154  O  O     . LYS A 1 49  ? -4.23400 8.29000   -5.35700  1.000 78.18741  ? 1465 LYS A O     1 
ATOM   155  C  CB    . LYS A 1 49  ? -5.35500 6.96100   -2.67400  1.000 77.87750  ? 1465 LYS A CB    1 
ATOM   156  C  CG    . LYS A 1 49  ? -6.12800 5.64600   -2.66000  1.000 79.10229  ? 1465 LYS A CG    1 
ATOM   157  C  CD    . LYS A 1 49  ? -6.89900 5.43200   -3.96900  1.000 89.29854  ? 1465 LYS A CD    1 
ATOM   158  C  CE    . LYS A 1 49  ? -8.25500 4.76400   -3.73200  1.000 92.52784  ? 1465 LYS A CE    1 
ATOM   159  N  NZ    . LYS A 1 49  ? -9.28900 5.18800   -4.72500  1.000 89.11917  ? 1465 LYS A NZ    1 
ATOM   160  N  N     . GLN A 1 50  ? -3.02700 9.11200   -3.64700  1.000 77.27746  ? 1466 GLN A N     1 
ATOM   161  C  CA    . GLN A 1 50  ? -2.66500 10.35400  -4.31900  1.000 79.08903  ? 1466 GLN A CA    1 
ATOM   162  C  C     . GLN A 1 50  ? -1.38300 10.23400  -5.14300  1.000 74.74482  ? 1466 GLN A C     1 
ATOM   163  O  O     . GLN A 1 50  ? -0.91100 11.24300  -5.67700  1.000 67.76994  ? 1466 GLN A O     1 
ATOM   164  C  CB    . GLN A 1 50  ? -2.50600 11.48200  -3.29600  1.000 80.96746  ? 1466 GLN A CB    1 
ATOM   165  C  CG    . GLN A 1 50  ? -3.72500 12.39300  -3.13100  1.000 95.94458  ? 1466 GLN A CG    1 
ATOM   166  C  CD    . GLN A 1 50  ? -5.00000 11.64100  -2.77800  1.000 108.37501 ? 1466 GLN A CD    1 
ATOM   167  O  OE1   . GLN A 1 50  ? -5.29200 11.41200  -1.60100  1.000 110.78320 ? 1466 GLN A OE1   1 
ATOM   168  N  NE2   . GLN A 1 50  ? -5.77600 11.27300  -3.79700  1.000 109.64622 ? 1466 GLN A NE2   1 
ATOM   169  N  N     . GLY A 1 51  ? -0.80100 9.03800   -5.24200  1.000 71.97658  ? 1467 GLY A N     1 
ATOM   170  C  CA    . GLY A 1 51  ? 0.44600  8.86200   -5.96100  1.000 70.10542  ? 1467 GLY A CA    1 
ATOM   171  C  C     . GLY A 1 51  ? 1.66700  9.53300   -5.36200  1.000 69.68094  ? 1467 GLY A C     1 
ATOM   172  O  O     . GLY A 1 51  ? 2.67000  9.69300   -6.06500  1.000 69.91661  ? 1467 GLY A O     1 
ATOM   173  N  N     . LYS A 1 52  ? 1.62900  9.94200   -4.09000  1.000 70.53320  ? 1468 LYS A N     1 
ATOM   174  C  CA    . LYS A 1 52  ? 2.80600  10.51300  -3.44800  1.000 72.22132  ? 1468 LYS A CA    1 
ATOM   175  C  C     . LYS A 1 52  ? 3.54900  9.49100   -2.60100  1.000 69.98989  ? 1468 LYS A C     1 
ATOM   176  O  O     . LYS A 1 52  ? 4.67600  9.76300   -2.17500  1.000 69.41350  ? 1468 LYS A O     1 
ATOM   177  C  CB    . LYS A 1 52  ? 2.41800  11.73100  -2.58800  1.000 84.88799  ? 1468 LYS A CB    1 
ATOM   178  C  CG    . LYS A 1 52  ? 3.56700  12.73000  -2.23900  1.000 98.47383  ? 1468 LYS A CG    1 
ATOM   179  C  CD    . LYS A 1 52  ? 4.31700  12.37600  -0.92300  1.000 98.16063  ? 1468 LYS A CD    1 
ATOM   180  C  CE    . LYS A 1 52  ? 3.61800  12.94500  0.33100   1.000 96.67164  ? 1468 LYS A CE    1 
ATOM   181  N  NZ    . LYS A 1 52  ? 4.14500  12.37300  1.60500   1.000 87.63130  ? 1468 LYS A NZ    1 
ATOM   182  N  N     . MET A 1 53  ? 2.97000  8.31600   -2.37300  1.000 66.33084  ? 1469 MET A N     1 
ATOM   183  C  CA    . MET A 1 53  ? 3.69100  7.24500   -1.70500  1.000 63.36488  ? 1469 MET A CA    1 
ATOM   184  C  C     . MET A 1 53  ? 3.48100  5.95200   -2.48400  1.000 59.42051  ? 1469 MET A C     1 
ATOM   185  O  O     . MET A 1 53  ? 2.44500  5.78600   -3.13300  1.000 61.40623  ? 1469 MET A O     1 
ATOM   186  C  CB    . MET A 1 53  ? 3.22500  7.05500   -0.25400  1.000 59.40322  ? 1469 MET A CB    1 
ATOM   187  C  CG    . MET A 1 53  ? 3.79700  8.08600   0.69300   1.000 65.07578  ? 1469 MET A CG    1 
ATOM   188  S  SD    . MET A 1 53  ? 3.50100  7.63800   2.40000   1.000 67.43961  ? 1469 MET A SD    1 
ATOM   189  C  CE    . MET A 1 53  ? 4.70100  6.32800   2.65400   1.000 61.33377  ? 1469 MET A CE    1 
ATOM   190  N  N     . PRO A 1 54  ? 4.44600  5.03400   -2.42600  1.000 54.53010  ? 1470 PRO A N     1 
ATOM   191  C  CA    . PRO A 1 54  ? 4.26400  3.74300   -3.10300  1.000 54.78393  ? 1470 PRO A CA    1 
ATOM   192  C  C     . PRO A 1 54  ? 3.11000  2.96600   -2.49200  1.000 57.34260  ? 1470 PRO A C     1 
ATOM   193  O  O     . PRO A 1 54  ? 2.62800  3.28200   -1.39800  1.000 57.35569  ? 1470 PRO A O     1 
ATOM   194  C  CB    . PRO A 1 54  ? 5.60200  3.02800   -2.88100  1.000 52.20935  ? 1470 PRO A CB    1 
ATOM   195  C  CG    . PRO A 1 54  ? 6.23200  3.71800   -1.71900  1.000 57.74990  ? 1470 PRO A CG    1 
ATOM   196  C  CD    . PRO A 1 54  ? 5.75000  5.13500   -1.75100  1.000 54.39481  ? 1470 PRO A CD    1 
ATOM   197  N  N     . CYS A 1 55  ? 2.65600  1.94900   -3.22800  1.000 49.26793  ? 1471 CYS A N     1 
ATOM   198  C  CA    . CYS A 1 55  ? 1.52200  1.13400   -2.80700  1.000 51.89019  ? 1471 CYS A CA    1 
ATOM   199  C  C     . CYS A 1 55  ? 1.79600  0.48900   -1.45200  1.000 56.47610  ? 1471 CYS A C     1 
ATOM   200  O  O     . CYS A 1 55  ? 2.93600  0.15300   -1.11700  1.000 53.89217  ? 1471 CYS A O     1 
ATOM   201  C  CB    . CYS A 1 55  ? 1.22800  0.05000   -3.84900  1.000 58.62669  ? 1471 CYS A CB    1 
ATOM   202  S  SG    . CYS A 1 55  ? 0.38300  0.60900   -5.37500  1.000 66.90579  ? 1471 CYS A SG    1 
ATOM   203  N  N     . TYR A 1 56  ? 0.73100  0.30400   -0.67600  1.000 56.60167  ? 1472 TYR A N     1 
ATOM   204  C  CA    . TYR A 1 56  ? 0.89300  -0.20400  0.67800   1.000 58.98646  ? 1472 TYR A CA    1 
ATOM   205  C  C     . TYR A 1 56  ? 1.42800  -1.63300  0.65700   1.000 55.72862  ? 1472 TYR A C     1 
ATOM   206  O  O     . TYR A 1 56  ? 1.03600  -2.45700  -0.17400  1.000 62.38792  ? 1472 TYR A O     1 
ATOM   207  C  CB    . TYR A 1 56  ? -0.43700 -0.14200  1.43400   1.000 59.67892  ? 1472 TYR A CB    1 
ATOM   208  C  CG    . TYR A 1 56  ? -0.39000 -0.71000  2.83700   1.000 61.81221  ? 1472 TYR A CG    1 
ATOM   209  C  CD1   . TYR A 1 56  ? -0.04300 0.08400   3.91800   1.000 62.20931  ? 1472 TYR A CD1   1 
ATOM   210  C  CD2   . TYR A 1 56  ? -0.71400 -2.03700  3.07900   1.000 62.78688  ? 1472 TYR A CD2   1 
ATOM   211  C  CE1   . TYR A 1 56  ? -0.01200 -0.43600  5.20300   1.000 68.39391  ? 1472 TYR A CE1   1 
ATOM   212  C  CE2   . TYR A 1 56  ? -0.68500 -2.56200  4.35500   1.000 64.80785  ? 1472 TYR A CE2   1 
ATOM   213  C  CZ    . TYR A 1 56  ? -0.33200 -1.75900  5.40700   1.000 64.75663  ? 1472 TYR A CZ    1 
ATOM   214  O  OH    . TYR A 1 56  ? -0.29700 -2.28300  6.66900   1.000 78.48985  ? 1472 TYR A OH    1 
ATOM   215  N  N     . PHE A 1 57  ? 2.36600  -1.90300  1.55800   1.000 54.19310  ? 1473 PHE A N     1 
ATOM   216  C  CA    . PHE A 1 57  ? 2.79000  -3.25100  1.90300   1.000 55.87394  ? 1473 PHE A CA    1 
ATOM   217  C  C     . PHE A 1 57  ? 2.90800  -3.32600  3.42600   1.000 55.07353  ? 1473 PHE A C     1 
ATOM   218  O  O     . PHE A 1 57  ? 2.94000  -2.29700  4.10800   1.000 51.08445  ? 1473 PHE A O     1 
ATOM   219  C  CB    . PHE A 1 57  ? 4.11700  -3.59600  1.22700   1.000 51.17172  ? 1473 PHE A CB    1 
ATOM   220  C  CG    . PHE A 1 57  ? 5.26000  -2.76600  1.71400   1.000 49.05585  ? 1473 PHE A CG    1 
ATOM   221  C  CD1   . PHE A 1 57  ? 5.51600  -1.53100  1.14400   1.000 48.57197  ? 1473 PHE A CD1   1 
ATOM   222  C  CD2   . PHE A 1 57  ? 6.06500  -3.20300  2.76000   1.000 48.47807  ? 1473 PHE A CD2   1 
ATOM   223  C  CE1   . PHE A 1 57  ? 6.56400  -0.74400  1.58900   1.000 49.09429  ? 1473 PHE A CE1   1 
ATOM   224  C  CE2   . PHE A 1 57  ? 7.12300  -2.42100  3.21600   1.000 49.54052  ? 1473 PHE A CE2   1 
ATOM   225  C  CZ    . PHE A 1 57  ? 7.37100  -1.18700  2.62200   1.000 46.91436  ? 1473 PHE A CZ    1 
ATOM   226  N  N     . ASP A 1 58  ? 2.97400  -4.54700  3.95900   1.000 58.37229  ? 1474 ASP A N     1 
ATOM   227  C  CA    . ASP A 1 58  ? 3.08400  -4.74900  5.40600   1.000 58.52412  ? 1474 ASP A CA    1 
ATOM   228  C  C     . ASP A 1 58  ? 4.51400  -4.48700  5.86800   1.000 55.22318  ? 1474 ASP A C     1 
ATOM   229  O  O     . ASP A 1 58  ? 5.43600  -5.21900  5.49000   1.000 56.62758  ? 1474 ASP A O     1 
ATOM   230  C  CB    . ASP A 1 58  ? 2.67400  -6.17000  5.78500   1.000 64.36447  ? 1474 ASP A CB    1 
ATOM   231  C  CG    . ASP A 1 58  ? 1.18400  -6.33100  5.92100   1.000 78.93464  ? 1474 ASP A CG    1 
ATOM   232  O  OD1   . ASP A 1 58  ? 0.52100  -5.37400  6.37000   1.000 84.17211  ? 1474 ASP A OD1   1 
ATOM   233  O  OD2   . ASP A 1 58  ? 0.67300  -7.42400  5.59100   1.000 89.87543  ? 1474 ASP A OD2   1 
ATOM   234  N  N     . LEU A 1 59  ? 4.70100  -3.46100  6.69400   1.000 51.45300  ? 1475 LEU A N     1 
ATOM   235  C  CA    . LEU A 1 59  ? 6.02300  -3.14400  7.22500   1.000 55.46341  ? 1475 LEU A CA    1 
ATOM   236  C  C     . LEU A 1 59  ? 6.39800  -4.13300  8.32300   1.000 58.14268  ? 1475 LEU A C     1 
ATOM   237  O  O     . LEU A 1 59  ? 5.60200  -4.37800  9.23500   1.000 61.43376  ? 1475 LEU A O     1 
ATOM   238  C  CB    . LEU A 1 59  ? 6.04600  -1.72200  7.77800   1.000 53.02627  ? 1475 LEU A CB    1 
ATOM   239  C  CG    . LEU A 1 59  ? 7.37900  -1.09800  8.20600   1.000 56.38516  ? 1475 LEU A CG    1 
ATOM   240  C  CD1   . LEU A 1 59  ? 8.34900  -0.96700  7.05600   1.000 51.98107  ? 1475 LEU A CD1   1 
ATOM   241  C  CD2   . LEU A 1 59  ? 7.11700  0.27000   8.80500   1.000 60.79477  ? 1475 LEU A CD2   1 
ATOM   242  N  N     . ILE A 1 60  ? 7.60300  -4.71600  8.23600   1.000 52.28080  ? 1476 ILE A N     1 
ATOM   243  C  CA    . ILE A 1 60  ? 8.10000  -5.60200  9.28600   1.000 54.11373  ? 1476 ILE A CA    1 
ATOM   244  C  C     . ILE A 1 60  ? 9.50900  -5.18200  9.68100   1.000 58.39431  ? 1476 ILE A C     1 
ATOM   245  O  O     . ILE A 1 60  ? 10.26800 -4.63900  8.87400   1.000 58.84857  ? 1476 ILE A O     1 
ATOM   246  C  CB    . ILE A 1 60  ? 8.08600  -7.09800  8.87000   1.000 52.71687  ? 1476 ILE A CB    1 
ATOM   247  C  CG1   . ILE A 1 60  ? 9.01100  -7.32900  7.67600   1.000 54.42756  ? 1476 ILE A CG1   1 
ATOM   248  C  CG2   . ILE A 1 60  ? 6.67300  -7.56900  8.57600   1.000 51.29318  ? 1476 ILE A CG2   1 
ATOM   249  C  CD1   . ILE A 1 60  ? 8.75100  -8.60700  6.92300   1.000 49.23614  ? 1476 ILE A CD1   1 
ATOM   250  N  N     . GLU A 1 61  ? 9.85600  -5.44800  10.93900  1.000 61.06145  ? 1477 GLU A N     1 
ATOM   251  C  CA    . GLU A 1 61  ? 11.16900 -5.11900  11.47400  1.000 63.55392  ? 1477 GLU A CA    1 
ATOM   252  C  C     . GLU A 1 61  ? 12.15800 -6.25900  11.34800  1.000 61.45886  ? 1477 GLU A C     1 
ATOM   253  O  O     . GLU A 1 61  ? 13.36200 -6.03100  11.50500  1.000 62.71428  ? 1477 GLU A O     1 
ATOM   254  C  CB    . GLU A 1 61  ? 11.06800 -4.74500  12.95700  1.000 69.88519  ? 1477 GLU A CB    1 
ATOM   255  C  CG    . GLU A 1 61  ? 10.19700 -3.54100  13.24400  1.000 81.71656  ? 1477 GLU A CG    1 
ATOM   256  C  CD    . GLU A 1 61  ? 10.91800 -2.21300  13.02700  1.000 86.15919  ? 1477 GLU A CD    1 
ATOM   257  O  OE1   . GLU A 1 61  ? 11.46700 -1.98000  11.91600  1.000 79.15272  ? 1477 GLU A OE1   1 
ATOM   258  O  OE2   . GLU A 1 61  ? 10.92700 -1.40300  13.97900  1.000 84.19884  ? 1477 GLU A OE2   1 
ATOM   259  N  N     . GLU A 1 62  ? 11.67400 -7.47400  11.09800  1.000 57.26889  ? 1478 GLU A N     1 
ATOM   260  C  CA    . GLU A 1 62  ? 12.51700 -8.65700  11.01600  1.000 57.02675  ? 1478 GLU A CA    1 
ATOM   261  C  C     . GLU A 1 62  ? 11.78200 -9.71300  10.20000  1.000 49.40742  ? 1478 GLU A C     1 
ATOM   262  O  O     . GLU A 1 62  ? 10.56800 -9.62600  9.99000   1.000 47.63615  ? 1478 GLU A O     1 
ATOM   263  C  CB    . GLU A 1 62  ? 12.89200 -9.18600  12.41500  1.000 56.98708  ? 1478 GLU A CB    1 
ATOM   264  C  CG    . GLU A 1 62  ? 11.79200 -9.96100  13.12100  1.000 59.91485  ? 1478 GLU A CG    1 
ATOM   265  C  CD    . GLU A 1 62  ? 12.11800 -10.27000 14.59500  1.000 67.69803  ? 1478 GLU A CD    1 
ATOM   266  O  OE1   . GLU A 1 62  ? 13.05200 -11.05200 14.86500  1.000 65.05140  ? 1478 GLU A OE1   1 
ATOM   267  O  OE2   . GLU A 1 62  ? 11.41800 -9.74900  15.49100  1.000 73.36790  ? 1478 GLU A OE2   1 
ATOM   268  N  N     . ASN A 1 63  ? 12.53200 -10.70400 9.72700   1.000 45.85127  ? 1479 ASN A N     1 
ATOM   269  C  CA    . ASN A 1 63  ? 11.96500 -11.68300 8.80900   1.000 52.18746  ? 1479 ASN A CA    1 
ATOM   270  C  C     . ASN A 1 63  ? 10.82100 -12.45100 9.46500   1.000 58.69295  ? 1479 ASN A C     1 
ATOM   271  O  O     . ASN A 1 63  ? 10.81100 -12.68200 10.67600  1.000 58.58160  ? 1479 ASN A O     1 
ATOM   272  C  CB    . ASN A 1 63  ? 13.04900 -12.65200 8.33700   1.000 52.32798  ? 1479 ASN A CB    1 
ATOM   273  C  CG    . ASN A 1 63  ? 13.98900 -12.02100 7.34400   1.000 50.27181  ? 1479 ASN A CG    1 
ATOM   274  O  OD1   . ASN A 1 63  ? 13.67600 -10.99400 6.76500   1.000 47.08346  ? 1479 ASN A OD1   1 
ATOM   275  N  ND2   . ASN A 1 63  ? 15.14500 -12.63400 7.13900   1.000 48.56784  ? 1479 ASN A ND2   1 
ATOM   276  N  N     . VAL A 1 64  ? 9.83800  -12.83500 8.65400   1.000 60.55349  ? 1480 VAL A N     1 
ATOM   277  C  CA    . VAL A 1 64  ? 8.71600  -13.65400 9.10700   1.000 59.79814  ? 1480 VAL A CA    1 
ATOM   278  C  C     . VAL A 1 64  ? 8.84800  -15.02800 8.46300   1.000 68.48076  ? 1480 VAL A C     1 
ATOM   279  O  O     . VAL A 1 64  ? 8.79800  -15.15100 7.23200   1.000 61.49165  ? 1480 VAL A O     1 
ATOM   280  C  CB    . VAL A 1 64  ? 7.36400  -13.02100 8.74900   1.000 62.69283  ? 1480 VAL A CB    1 
ATOM   281  C  CG1   . VAL A 1 64  ? 6.28200  -13.61200 9.60800   1.000 67.77147  ? 1480 VAL A CG1   1 
ATOM   282  C  CG2   . VAL A 1 64  ? 7.40800  -11.51600 8.91200   1.000 58.72918  ? 1480 VAL A CG2   1 
ATOM   283  N  N     . TYR A 1 65  ? 9.01300  -16.05800 9.28700   1.000 72.50821  ? 1481 TYR A N     1 
ATOM   284  C  CA    . TYR A 1 65  ? 9.04600  -17.43500 8.80900   1.000 75.26085  ? 1481 TYR A CA    1 
ATOM   285  C  C     . TYR A 1 65  ? 7.63700  -17.99500 8.75800   1.000 85.04310  ? 1481 TYR A C     1 
ATOM   286  O  O     . TYR A 1 65  ? 6.76300  -17.60200 9.53300   1.000 92.53891  ? 1481 TYR A O     1 
ATOM   287  C  CB    . TYR A 1 65  ? 9.91300  -18.31700 9.70900   1.000 82.31860  ? 1481 TYR A CB    1 
ATOM   288  C  CG    . TYR A 1 65  ? 11.36800 -17.97000 9.61000   1.000 74.46993  ? 1481 TYR A CG    1 
ATOM   289  C  CD1   . TYR A 1 65  ? 11.86000 -16.80600 10.19900  1.000 67.35244  ? 1481 TYR A CD1   1 
ATOM   290  C  CD2   . TYR A 1 65  ? 12.24900 -18.78500 8.91400   1.000 67.66924  ? 1481 TYR A CD2   1 
ATOM   291  C  CE1   . TYR A 1 65  ? 13.19100 -16.45800 10.10000  1.000 66.58831  ? 1481 TYR A CE1   1 
ATOM   292  C  CE2   . TYR A 1 65  ? 13.58400 -18.44900 8.80900   1.000 66.67871  ? 1481 TYR A CE2   1 
ATOM   293  C  CZ    . TYR A 1 65  ? 14.05100 -17.28000 9.40200   1.000 65.35670  ? 1481 TYR A CZ    1 
ATOM   294  O  OH    . TYR A 1 65  ? 15.38200 -16.94200 9.31300   1.000 68.29389  ? 1481 TYR A OH    1 
ATOM   295  N  N     . LEU A 1 66  ? 7.42100  -18.93600 7.84700   1.000 89.37222  ? 1482 LEU A N     1 
ATOM   296  C  CA    . LEU A 1 66  ? 6.08900  -19.50400 7.67400   1.000 94.61625  ? 1482 LEU A CA    1 
ATOM   297  C  C     . LEU A 1 66  ? 5.87500  -20.63800 8.68500   1.000 102.67452 ? 1482 LEU A C     1 
ATOM   298  O  O     . LEU A 1 66  ? 5.56300  -21.77900 8.34700   1.000 105.76017 ? 1482 LEU A O     1 
ATOM   299  C  CB    . LEU A 1 66  ? 5.89400  -19.94100 6.22900   1.000 90.58022  ? 1482 LEU A CB    1 
ATOM   300  C  CG    . LEU A 1 66  ? 5.50400  -18.77600 5.29200   1.000 91.20418  ? 1482 LEU A CG    1 
ATOM   301  C  CD1   . LEU A 1 66  ? 4.14200  -18.20000 5.65200   1.000 96.98694  ? 1482 LEU A CD1   1 
ATOM   302  C  CD2   . LEU A 1 66  ? 6.52900  -17.64100 5.24900   1.000 72.02480  ? 1482 LEU A CD2   1 
ATOM   303  N  N     . THR A 1 67  ? 6.07400  -20.27000 9.95800   1.000 109.21460 ? 1483 THR A N     1 
ATOM   304  C  CA    . THR A 1 67  ? 5.88400  -21.01800 11.20800  1.000 113.94176 ? 1483 THR A CA    1 
ATOM   305  C  C     . THR A 1 67  ? 6.90800  -22.13900 11.40400  1.000 114.31187 ? 1483 THR A C     1 
ATOM   306  O  O     . THR A 1 67  ? 6.88900  -22.79900 12.45200  1.000 119.55249 ? 1483 THR A O     1 
ATOM   307  C  CB    . THR A 1 67  ? 4.45200  -21.57300 11.35200  1.000 114.66552 ? 1483 THR A CB    1 
ATOM   308  O  OG1   . THR A 1 67  ? 3.51400  -20.54900 11.00500  1.000 117.23394 ? 1483 THR A OG1   1 
ATOM   309  C  CG2   . THR A 1 67  ? 4.15000  -21.98000 12.79600  1.000 115.75135 ? 1483 THR A CG2   1 
ATOM   310  N  N     . GLU A 1 68  ? 7.83400  -22.35100 10.46600  1.000 115.11874 ? 1484 GLU A N     1 
ATOM   311  C  CA    . GLU A 1 68  ? 8.85600  -23.37500 10.67600  1.000 118.46868 ? 1484 GLU A CA    1 
ATOM   312  C  C     . GLU A 1 68  ? 9.70500  -23.04400 11.90600  1.000 117.96338 ? 1484 GLU A C     1 
ATOM   313  O  O     . GLU A 1 68  ? 9.70200  -23.79400 12.89000  1.000 120.75788 ? 1484 GLU A O     1 
ATOM   314  C  CB    . GLU A 1 68  ? 9.71200  -23.56000 9.40600   1.000 117.01282 ? 1484 GLU A CB    1 
ATOM   315  C  CG    . GLU A 1 68  ? 10.46600 -22.33900 8.85300   1.000 113.00910 ? 1484 GLU A CG    1 
ATOM   316  C  CD    . GLU A 1 68  ? 10.36200 -22.19800 7.32800   1.000 113.05489 ? 1484 GLU A CD    1 
ATOM   317  O  OE1   . GLU A 1 68  ? 9.42800  -21.51400 6.84400   1.000 114.04412 ? 1484 GLU A OE1   1 
ATOM   318  O  OE2   . GLU A 1 68  ? 11.23600 -22.74200 6.61100   1.000 109.00283 ? 1484 GLU A OE2   1 
ATOM   319  N  N     . ARG A 1 69  ? 10.40600 -21.90200 11.87700  1.000 110.52434 ? 1485 ARG A N     1 
ATOM   320  C  CA    . ARG A 1 69  ? 11.13300 -21.31000 13.01500  1.000 110.82835 ? 1485 ARG A CA    1 
ATOM   321  C  C     . ARG A 1 69  ? 11.56900 -22.29200 14.11700  1.000 105.67022 ? 1485 ARG A C     1 
ATOM   322  O  O     . ARG A 1 69  ? 12.45100 -21.99300 14.92500  1.000 97.49979  ? 1485 ARG A O     1 
ATOM   323  C  CB    . ARG A 1 69  ? 10.27000 -20.21700 13.64500  1.000 112.37563 ? 1485 ARG A CB    1 
ATOM   324  C  CG    . ARG A 1 69  ? 10.90000 -18.83500 13.62400  1.000 111.81995 ? 1485 ARG A CG    1 
ATOM   325  C  CD    . ARG A 1 69  ? 9.92600  -17.78100 14.14900  1.000 119.19751 ? 1485 ARG A CD    1 
ATOM   326  N  NE    . ARG A 1 69  ? 8.68100  -17.73300 13.37800  1.000 123.66632 ? 1485 ARG A NE    1 
ATOM   327  C  CZ    . ARG A 1 69  ? 7.48900  -18.11700 13.83600  1.000 125.56182 ? 1485 ARG A CZ    1 
ATOM   328  N  NH1   . ARG A 1 69  ? 7.36200  -18.58500 15.07300  1.000 126.48850 ? 1485 ARG A NH1   1 
ATOM   329  N  NH2   . ARG A 1 69  ? 6.41900  -18.03300 13.05500  1.000 122.66094 ? 1485 ARG A NH2   1 
ATOM   330  N  N     . ILE A 1 78  ? 22.95300 -23.94900 25.75200  1.000 116.55513 ? 1494 ILE A N     1 
ATOM   331  C  CA    . ILE A 1 78  ? 24.18700 -23.22800 26.05300  1.000 118.73395 ? 1494 ILE A CA    1 
ATOM   332  C  C     . ILE A 1 78  ? 24.58600 -22.33200 24.87400  1.000 118.52728 ? 1494 ILE A C     1 
ATOM   333  O  O     . ILE A 1 78  ? 25.08700 -22.81800 23.86000  1.000 121.07475 ? 1494 ILE A O     1 
ATOM   334  C  CB    . ILE A 1 78  ? 25.31900 -24.21600 26.42900  1.000 121.89328 ? 1494 ILE A CB    1 
ATOM   335  C  CG1   . ILE A 1 78  ? 25.25400 -25.48100 25.56200  1.000 123.40170 ? 1494 ILE A CG1   1 
ATOM   336  C  CG2   . ILE A 1 78  ? 25.21500 -24.61300 27.89500  1.000 123.96637 ? 1494 ILE A CG2   1 
ATOM   337  C  CD1   . ILE A 1 78  ? 26.31600 -26.52000 25.90100  1.000 121.24018 ? 1494 ILE A CD1   1 
ATOM   338  N  N     . LYS A 1 79  ? 24.36800 -21.02100 25.00600  1.000 115.82516 ? 1495 LYS A N     1 
ATOM   339  C  CA    . LYS A 1 79  ? 24.54200 -20.06800 23.90800  1.000 114.56992 ? 1495 LYS A CA    1 
ATOM   340  C  C     . LYS A 1 79  ? 25.64600 -19.07600 24.25800  1.000 117.55793 ? 1495 LYS A C     1 
ATOM   341  O  O     . LYS A 1 79  ? 25.43700 -18.17400 25.07800  1.000 118.14026 ? 1495 LYS A O     1 
ATOM   342  C  CB    . LYS A 1 79  ? 23.22900 -19.33500 23.60800  1.000 108.59317 ? 1495 LYS A CB    1 
ATOM   343  C  CG    . LYS A 1 79  ? 23.20000 -18.58700 22.26600  1.000 104.62460 ? 1495 LYS A CG    1 
ATOM   344  C  CD    . LYS A 1 79  ? 23.50700 -17.10000 22.43200  1.000 100.46131 ? 1495 LYS A CD    1 
ATOM   345  C  CE    . LYS A 1 79  ? 23.92300 -16.44100 21.11900  1.000 88.45713  ? 1495 LYS A CE    1 
ATOM   346  N  NZ    . LYS A 1 79  ? 23.46700 -15.01700 20.98700  1.000 78.83440  ? 1495 LYS A NZ    1 
ATOM   347  N  N     . ARG A 1 80  ? 26.81000 -19.21900 23.61500  1.000 117.67869 ? 1496 ARG A N     1 
ATOM   348  C  CA    . ARG A 1 80  ? 27.93700 -18.31400 23.85700  1.000 114.61880 ? 1496 ARG A CA    1 
ATOM   349  C  C     . ARG A 1 80  ? 28.77000 -18.22800 22.57800  1.000 114.02190 ? 1496 ARG A C     1 
ATOM   350  O  O     . ARG A 1 80  ? 29.62200 -19.08700 22.32500  1.000 111.48255 ? 1496 ARG A O     1 
ATOM   351  C  CB    . ARG A 1 80  ? 28.78200 -18.77800 25.03600  1.000 113.20980 ? 1496 ARG A CB    1 
ATOM   352  C  CG    . ARG A 1 80  ? 29.09100 -20.28000 25.06600  1.000 117.79736 ? 1496 ARG A CG    1 
ATOM   353  C  CD    . ARG A 1 80  ? 28.04600 -21.07700 25.84500  1.000 121.47027 ? 1496 ARG A CD    1 
ATOM   354  N  NE    . ARG A 1 80  ? 27.75100 -20.47200 27.14100  1.000 122.60832 ? 1496 ARG A NE    1 
ATOM   355  C  CZ    . ARG A 1 80  ? 28.56900 -20.49500 28.18900  1.000 121.92520 ? 1496 ARG A CZ    1 
ATOM   356  N  NH1   . ARG A 1 80  ? 29.73800 -21.11800 28.11200  1.000 124.92211 ? 1496 ARG A NH1   1 
ATOM   357  N  NH2   . ARG A 1 80  ? 28.21000 -19.90500 29.32000  1.000 116.95733 ? 1496 ARG A NH2   1 
ATOM   358  N  N     . MET A 1 81  ? 28.51000 -17.20500 21.77200  1.000 111.83777 ? 1497 MET A N     1 
ATOM   359  C  CA    . MET A 1 81  ? 29.38300 -16.81900 20.66500  1.000 111.52506 ? 1497 MET A CA    1 
ATOM   360  C  C     . MET A 1 81  ? 29.83900 -15.38600 20.93600  1.000 101.97705 ? 1497 MET A C     1 
ATOM   361  O  O     . MET A 1 81  ? 29.43900 -14.42800 20.26000  1.000 96.61648  ? 1497 MET A O     1 
ATOM   362  C  CB    . MET A 1 81  ? 28.67200 -16.97400 19.28600  1.000 116.43423 ? 1497 MET A CB    1 
ATOM   363  C  CG    . MET A 1 81  ? 29.48100 -16.47800 18.08000  1.000 123.95846 ? 1497 MET A CG    1 
ATOM   364  S  SD    . MET A 1 81  ? 30.91100 -17.51100 17.65500  1.000 140.36569 ? 1497 MET A SD    1 
ATOM   365  C  CE    . MET A 1 81  ? 32.23000 -16.29800 17.75800  1.000 129.50913 ? 1497 MET A CE    1 
ATOM   366  N  N     . GLN A 1 82  ? 30.65500 -15.23800 21.97300  1.000 96.58973  ? 1498 GLN A N     1 
ATOM   367  C  CA    . GLN A 1 82  ? 31.22000 -13.95000 22.33200  1.000 87.27460  ? 1498 GLN A CA    1 
ATOM   368  C  C     . GLN A 1 82  ? 32.43900 -13.66800 21.46400  1.000 82.82621  ? 1498 GLN A C     1 
ATOM   369  O  O     . GLN A 1 82  ? 33.08400 -14.58600 20.94900  1.000 96.71835  ? 1498 GLN A O     1 
ATOM   370  C  CB    . GLN A 1 82  ? 31.61200 -13.94400 23.80800  1.000 87.00105  ? 1498 GLN A CB    1 
ATOM   371  C  CG    . GLN A 1 82  ? 30.47000 -13.64000 24.75800  1.000 92.86650  ? 1498 GLN A CG    1 
ATOM   372  C  CD    . GLN A 1 82  ? 30.94400 -12.94600 26.02000  1.000 103.94817 ? 1498 GLN A CD    1 
ATOM   373  O  OE1   . GLN A 1 82  ? 31.51400 -13.57500 26.91500  1.000 112.69395 ? 1498 GLN A OE1   1 
ATOM   374  N  NE2   . GLN A 1 82  ? 30.69500 -11.64500 26.10800  1.000 101.27416 ? 1498 GLN A NE2   1 
ATOM   375  N  N     . CYS A 1 83  ? 32.73600 -12.38900 21.27600  1.000 76.29840  ? 1499 CYS A N     1 
ATOM   376  C  CA    . CYS A 1 83  ? 33.96100 -12.00300 20.59300  1.000 73.00275  ? 1499 CYS A CA    1 
ATOM   377  C  C     . CYS A 1 83  ? 35.08100 -11.94800 21.62800  1.000 76.17903  ? 1499 CYS A C     1 
ATOM   378  O  O     . CYS A 1 83  ? 34.88800 -12.29100 22.79600  1.000 74.35800  ? 1499 CYS A O     1 
ATOM   379  C  CB    . CYS A 1 83  ? 33.77600 -10.67500 19.86000  1.000 68.17154  ? 1499 CYS A CB    1 
ATOM   380  S  SG    . CYS A 1 83  ? 33.68700 -9.23100  20.95400  1.000 60.40227  ? 1499 CYS A SG    1 
ATOM   381  N  N     . GLU A 1 84  ? 36.27000 -11.50900 21.22300  1.000 74.35685  ? 1500 GLU A N     1 
ATOM   382  C  CA    . GLU A 1 84  ? 37.40100 -11.42700 22.13600  1.000 73.22605  ? 1500 GLU A CA    1 
ATOM   383  C  C     . GLU A 1 84  ? 37.85900 -9.99300  22.36300  1.000 70.28458  ? 1500 GLU A C     1 
ATOM   384  O  O     . GLU A 1 84  ? 38.99300 -9.76700  22.80200  1.000 70.35691  ? 1500 GLU A O     1 
ATOM   385  C  CB    . GLU A 1 84  ? 38.56200 -12.27500 21.62200  1.000 81.88880  ? 1500 GLU A CB    1 
ATOM   386  C  CG    . GLU A 1 84  ? 38.67800 -13.63300 22.29900  1.000 90.01472  ? 1500 GLU A CG    1 
ATOM   387  C  CD    . GLU A 1 84  ? 39.42200 -14.65800 21.45800  1.000 100.29914 ? 1500 GLU A CD    1 
ATOM   388  O  OE1   . GLU A 1 84  ? 40.61300 -14.42900 21.15400  1.000 101.99907 ? 1500 GLU A OE1   1 
ATOM   389  O  OE2   . GLU A 1 84  ? 38.81400 -15.69000 21.09600  1.000 101.88476 ? 1500 GLU A OE2   1 
ATOM   390  N  N     . CYS A 1 85  ? 37.00700 -9.02000  22.06900  1.000 66.57713  ? 1501 CYS A N     1 
ATOM   391  C  CA    . CYS A 1 85  ? 37.38100 -7.63100  22.27300  1.000 65.57504  ? 1501 CYS A CA    1 
ATOM   392  C  C     . CYS A 1 85  ? 37.50200 -7.34200  23.76800  1.000 66.88081  ? 1501 CYS A C     1 
ATOM   393  O  O     . CYS A 1 85  ? 36.63400 -7.72300  24.56000  1.000 65.09347  ? 1501 CYS A O     1 
ATOM   394  C  CB    . CYS A 1 85  ? 36.35300 -6.71700  21.60600  1.000 62.78019  ? 1501 CYS A CB    1 
ATOM   395  S  SG    . CYS A 1 85  ? 36.09000 -7.07000  19.80100  1.000 59.51218  ? 1501 CYS A SG    1 
ATOM   396  N  N     . THR A 1 86  ? 38.60300 -6.72400  24.16300  1.000 68.34051  ? 1502 THR A N     1 
ATOM   397  C  CA    . THR A 1 86  ? 38.72200 -6.29500  25.55300  1.000 70.80219  ? 1502 THR A CA    1 
ATOM   398  C  C     . THR A 1 86  ? 37.82500 -5.07700  25.77600  1.000 70.14805  ? 1502 THR A C     1 
ATOM   399  O  O     . THR A 1 86  ? 37.89300 -4.11700  25.00400  1.000 68.10297  ? 1502 THR A O     1 
ATOM   400  C  CB    . THR A 1 86  ? 40.16100 -5.95000  25.91500  1.000 73.65762  ? 1502 THR A CB    1 
ATOM   401  O  OG1   . THR A 1 86  ? 40.69300 -5.04600  24.94100  1.000 75.08155  ? 1502 THR A OG1   1 
ATOM   402  C  CG2   . THR A 1 86  ? 41.02300 -7.20900  25.97600  1.000 70.82543  ? 1502 THR A CG2   1 
ATOM   403  N  N     . PRO A 1 87  ? 36.99300 -5.08700  26.81700  1.000 68.48260  ? 1503 PRO A N     1 
ATOM   404  C  CA    . PRO A 1 87  ? 35.99300 -4.01700  26.98100  1.000 65.76765  ? 1503 PRO A CA    1 
ATOM   405  C  C     . PRO A 1 87  ? 36.62700 -2.63800  27.07900  1.000 66.36069  ? 1503 PRO A C     1 
ATOM   406  O  O     . PRO A 1 87  ? 37.63400 -2.44300  27.76000  1.000 69.21801  ? 1503 PRO A O     1 
ATOM   407  C  CB    . PRO A 1 87  ? 35.28700 -4.39800  28.29100  1.000 66.37571  ? 1503 PRO A CB    1 
ATOM   408  C  CG    . PRO A 1 87  ? 36.23900 -5.29700  29.00700  1.000 68.69909  ? 1503 PRO A CG    1 
ATOM   409  C  CD    . PRO A 1 87  ? 36.97700 -6.04700  27.93100  1.000 67.94187  ? 1503 PRO A CD    1 
ATOM   410  N  N     . LEU A 1 88  ? 36.02000 -1.67300  26.39500  1.000 67.51913  ? 1504 LEU A N     1 
ATOM   411  C  CA    . LEU A 1 88  ? 36.47800 -0.29600  26.48500  1.000 67.11271  ? 1504 LEU A CA    1 
ATOM   412  C  C     . LEU A 1 88  ? 36.20400 0.26100   27.87400  1.000 72.21061  ? 1504 LEU A C     1 
ATOM   413  O  O     . LEU A 1 88  ? 35.11600 0.07900   28.42900  1.000 70.15958  ? 1504 LEU A O     1 
ATOM   414  C  CB    . LEU A 1 88  ? 35.78100 0.57100   25.43700  1.000 67.56557  ? 1504 LEU A CB    1 
ATOM   415  C  CG    . LEU A 1 88  ? 36.29300 0.47500   23.99500  1.000 65.65314  ? 1504 LEU A CG    1 
ATOM   416  C  CD1   . LEU A 1 88  ? 35.72500 1.61300   23.16700  1.000 64.32236  ? 1504 LEU A CD1   1 
ATOM   417  C  CD2   . LEU A 1 88  ? 37.81900 0.47200   23.92100  1.000 68.44911  ? 1504 LEU A CD2   1 
ATOM   418  N  N     . SER A 1 89  ? 37.20400 0.94100   28.43500  1.000 72.84427  ? 1505 SER A N     1 
ATOM   419  C  CA    . SER A 1 89  ? 37.00700 1.70500   29.65800  1.000 76.75688  ? 1505 SER A CA    1 
ATOM   420  C  C     . SER A 1 89  ? 36.07200 2.88300   29.40700  1.000 79.57669  ? 1505 SER A C     1 
ATOM   421  O  O     . SER A 1 89  ? 35.85800 3.31900   28.27200  1.000 80.31094  ? 1505 SER A O     1 
ATOM   422  C  CB    . SER A 1 89  ? 38.33900 2.22000   30.19800  1.000 72.43295  ? 1505 SER A CB    1 
ATOM   423  O  OG    . SER A 1 89  ? 38.67800 3.44800   29.58400  1.000 76.70582  ? 1505 SER A OG    1 
ATOM   424  N  N     . LYS A 1 90  ? 35.51500 3.41400   30.49200  1.000 83.83743  ? 1506 LYS A N     1 
ATOM   425  C  CA    . LYS A 1 90  ? 34.59100 4.52700   30.33700  1.000 86.29605  ? 1506 LYS A CA    1 
ATOM   426  C  C     . LYS A 1 90  ? 35.30900 5.81200   29.92900  1.000 83.48519  ? 1506 LYS A C     1 
ATOM   427  O  O     . LYS A 1 90  ? 34.66300 6.71500   29.38700  1.000 89.21745  ? 1506 LYS A O     1 
ATOM   428  C  CB    . LYS A 1 90  ? 33.77100 4.71300   31.62500  1.000 91.47562  ? 1506 LYS A CB    1 
ATOM   429  C  CG    . LYS A 1 90  ? 33.37600 3.37800   32.31800  1.000 100.22045 ? 1506 LYS A CG    1 
ATOM   430  C  CD    . LYS A 1 90  ? 32.66100 2.38900   31.36100  1.000 103.96133 ? 1506 LYS A CD    1 
ATOM   431  C  CE    . LYS A 1 90  ? 31.54300 1.59300   32.04000  1.000 100.06829 ? 1506 LYS A CE    1 
ATOM   432  N  NZ    . LYS A 1 90  ? 30.91200 0.57000   31.12900  1.000 94.81922  ? 1506 LYS A NZ    1 
ATOM   433  N  N     . ASP A 1 91  ? 36.63200 5.89500   30.13200  1.000 82.81701  ? 1507 ASP A N     1 
ATOM   434  C  CA    . ASP A 1 91  ? 37.41000 6.99800   29.57200  1.000 82.47166  ? 1507 ASP A CA    1 
ATOM   435  C  C     . ASP A 1 91  ? 37.66300 6.81500   28.07800  1.000 79.89585  ? 1507 ASP A C     1 
ATOM   436  O  O     . ASP A 1 91  ? 37.68900 7.79700   27.32700  1.000 79.54524  ? 1507 ASP A O     1 
ATOM   437  C  CB    . ASP A 1 91  ? 38.74400 7.13500   30.29800  1.000 88.44529  ? 1507 ASP A CB    1 
ATOM   438  C  CG    . ASP A 1 91  ? 38.58200 7.34900   31.78300  1.000 101.29341 ? 1507 ASP A CG    1 
ATOM   439  O  OD1   . ASP A 1 91  ? 38.46000 8.52100   32.20200  1.000 107.37753 ? 1507 ASP A OD1   1 
ATOM   440  O  OD2   . ASP A 1 91  ? 38.56500 6.34600   32.52800  1.000 107.02222 ? 1507 ASP A OD2   1 
ATOM   441  N  N     . GLU A 1 92  ? 37.87800 5.57400   27.63100  1.000 77.30529  ? 1508 GLU A N     1 
ATOM   442  C  CA    . GLU A 1 92  ? 38.08700 5.33400   26.20700  1.000 76.57034  ? 1508 GLU A CA    1 
ATOM   443  C  C     . GLU A 1 92  ? 36.82800 5.65600   25.41400  1.000 71.64745  ? 1508 GLU A C     1 
ATOM   444  O  O     . GLU A 1 92  ? 36.89100 6.29700   24.35700  1.000 67.51966  ? 1508 GLU A O     1 
ATOM   445  C  CB    . GLU A 1 92  ? 38.52500 3.89000   25.97700  1.000 72.12580  ? 1508 GLU A CB    1 
ATOM   446  C  CG    . GLU A 1 92  ? 40.01400 3.68300   26.13000  1.000 76.36534  ? 1508 GLU A CG    1 
ATOM   447  C  CD    . GLU A 1 92  ? 40.37000 2.25100   26.45400  1.000 76.30098  ? 1508 GLU A CD    1 
ATOM   448  O  OE1   . GLU A 1 92  ? 39.46400 1.48800   26.84600  1.000 80.63748  ? 1508 GLU A OE1   1 
ATOM   449  O  OE2   . GLU A 1 92  ? 41.55500 1.88600   26.30900  1.000 80.54813  ? 1508 GLU A OE2   1 
ATOM   450  N  N     . ARG A 1 93  ? 35.67300 5.21400   25.91200  1.000 73.12352  ? 1509 ARG A N     1 
ATOM   451  C  CA    . ARG A 1 93  ? 34.39600 5.66000   25.37400  1.000 67.70735  ? 1509 ARG A CA    1 
ATOM   452  C  C     . ARG A 1 93  ? 34.38700 7.17100   25.21400  1.000 67.17319  ? 1509 ARG A C     1 
ATOM   453  O  O     . ARG A 1 93  ? 34.11000 7.69000   24.12900  1.000 70.33361  ? 1509 ARG A O     1 
ATOM   454  C  CB    . ARG A 1 93  ? 33.25700 5.19800   26.29100  1.000 65.62775  ? 1509 ARG A CB    1 
ATOM   455  C  CG    . ARG A 1 93  ? 31.88900 5.74900   25.93400  1.000 61.85707  ? 1509 ARG A CG    1 
ATOM   456  C  CD    . ARG A 1 93  ? 31.40100 5.16700   24.61200  1.000 63.52555  ? 1509 ARG A CD    1 
ATOM   457  N  NE    . ARG A 1 93  ? 30.07500 5.64900   24.22300  1.000 59.85662  ? 1509 ARG A NE    1 
ATOM   458  C  CZ    . ARG A 1 93  ? 29.46900 5.31000   23.09000  1.000 60.91682  ? 1509 ARG A CZ    1 
ATOM   459  N  NH1   . ARG A 1 93  ? 30.07100 4.48300   22.24500  1.000 63.11218  ? 1509 ARG A NH1   1 
ATOM   460  N  NH2   . ARG A 1 93  ? 28.26800 5.79200   22.79800  1.000 58.09406  ? 1509 ARG A NH2   1 
ATOM   461  N  N     . ALA A 1 94  ? 34.72800 7.89100   26.28900  1.000 70.72514  ? 1510 ALA A N     1 
ATOM   462  C  CA    . ALA A 1 94  ? 34.76900 9.34500   26.25600  1.000 68.26815  ? 1510 ALA A CA    1 
ATOM   463  C  C     . ALA A 1 94  ? 35.77900 9.89400   25.25400  1.000 69.86855  ? 1510 ALA A C     1 
ATOM   464  O  O     . ALA A 1 94  ? 35.63500 11.04200  24.82600  1.000 66.44467  ? 1510 ALA A O     1 
ATOM   465  C  CB    . ALA A 1 94  ? 35.07000 9.89700   27.65600  1.000 72.47334  ? 1510 ALA A CB    1 
ATOM   466  N  N     . GLN A 1 95  ? 36.78900 9.12100   24.86500  1.000 74.33593  ? 1511 GLN A N     1 
ATOM   467  C  CA    . GLN A 1 95  ? 37.80800 9.60400   23.94200  1.000 72.58953  ? 1511 GLN A CA    1 
ATOM   468  C  C     . GLN A 1 95  ? 37.48500 9.28500   22.49300  1.000 74.15581  ? 1511 GLN A C     1 
ATOM   469  O  O     . GLN A 1 95  ? 38.24700 9.67200   21.60300  1.000 75.67896  ? 1511 GLN A O     1 
ATOM   470  C  CB    . GLN A 1 95  ? 39.18400 9.04000   24.31700  1.000 75.81790  ? 1511 GLN A CB    1 
ATOM   471  C  CG    . GLN A 1 95  ? 39.86300 9.85300   25.42500  1.000 79.06862  ? 1511 GLN A CG    1 
ATOM   472  C  CD    . GLN A 1 95  ? 40.95200 9.08200   26.13900  1.000 88.02420  ? 1511 GLN A CD    1 
ATOM   473  O  OE1   . GLN A 1 95  ? 41.25700 7.94400   25.77500  1.000 91.84409  ? 1511 GLN A OE1   1 
ATOM   474  N  NE2   . GLN A 1 95  ? 41.54200 9.69300   27.16900  1.000 89.62439  ? 1511 GLN A NE2   1 
ATOM   475  N  N     . GLY A 1 96  ? 36.37300 8.60000   22.23900  1.000 74.44463  ? 1512 GLY A N     1 
ATOM   476  C  CA    . GLY A 1 96  ? 35.89900 8.34600   20.89800  1.000 71.81482  ? 1512 GLY A CA    1 
ATOM   477  C  C     . GLY A 1 96  ? 36.22200 6.98200   20.34600  1.000 72.16955  ? 1512 GLY A C     1 
ATOM   478  O  O     . GLY A 1 96  ? 35.91300 6.71900   19.17500  1.000 74.75519  ? 1512 GLY A O     1 
ATOM   479  N  N     . GLU A 1 97  ? 36.82200 6.10600   21.14400  1.000 71.00738  ? 1513 GLU A N     1 
ATOM   480  C  CA    . GLU A 1 97  ? 37.17500 4.78300   20.65900  1.000 70.48842  ? 1513 GLU A CA    1 
ATOM   481  C  C     . GLU A 1 97  ? 35.92000 3.97700   20.34400  1.000 68.05435  ? 1513 GLU A C     1 
ATOM   482  O  O     . GLU A 1 97  ? 34.85100 4.18800   20.92500  1.000 67.67013  ? 1513 GLU A O     1 
ATOM   483  C  CB    . GLU A 1 97  ? 38.04900 4.06300   21.68700  1.000 72.32018  ? 1513 GLU A CB    1 
ATOM   484  C  CG    . GLU A 1 97  ? 39.49300 4.59400   21.77600  1.000 78.22462  ? 1513 GLU A CG    1 
ATOM   485  C  CD    . GLU A 1 97  ? 40.23400 4.51700   20.44500  1.000 88.79604  ? 1513 GLU A CD    1 
ATOM   486  O  OE1   . GLU A 1 97  ? 39.90800 3.62800   19.62300  1.000 96.29725  ? 1513 GLU A OE1   1 
ATOM   487  O  OE2   . GLU A 1 97  ? 41.13400 5.35100   20.21200  1.000 95.51821  ? 1513 GLU A OE2   1 
ATOM   488  N  N     . ILE A 1 98  ? 36.04200 3.07300   19.39000  1.000 67.58048  ? 1514 ILE A N     1 
ATOM   489  C  CA    . ILE A 1 98  ? 34.90700 2.27600   18.95000  1.000 60.99217  ? 1514 ILE A CA    1 
ATOM   490  C  C     . ILE A 1 98  ? 34.94200 0.94400   19.67700  1.000 54.68065  ? 1514 ILE A C     1 
ATOM   491  O  O     . ILE A 1 98  ? 36.01200 0.43400   20.01000  1.000 53.71207  ? 1514 ILE A O     1 
ATOM   492  C  CB    . ILE A 1 98  ? 34.92300 2.09100   17.41600  1.000 60.84886  ? 1514 ILE A CB    1 
ATOM   493  C  CG1   . ILE A 1 98  ? 35.24100 3.42500   16.73900  1.000 64.26709  ? 1514 ILE A CG1   1 
ATOM   494  C  CG2   . ILE A 1 98  ? 33.61100 1.48200   16.91900  1.000 55.77893  ? 1514 ILE A CG2   1 
ATOM   495  C  CD1   . ILE A 1 98  ? 34.07500 4.39000   16.67500  1.000 66.51974  ? 1514 ILE A CD1   1 
ATOM   496  N  N     . ALA A 1 99  ? 33.76800 0.37700   19.93100  1.000 55.70576  ? 1515 ALA A N     1 
ATOM   497  C  CA    . ALA A 1 99  ? 33.64800 -0.91900  20.58700  1.000 55.04131  ? 1515 ALA A CA    1 
ATOM   498  C  C     . ALA A 1 99  ? 33.28700 -1.97300  19.55200  1.000 55.24391  ? 1515 ALA A C     1 
ATOM   499  O  O     . ALA A 1 99  ? 32.28400 -1.82300  18.84400  1.000 50.93985  ? 1515 ALA A O     1 
ATOM   500  C  CB    . ALA A 1 99  ? 32.57100 -0.88300  21.66200  1.000 55.97783  ? 1515 ALA A CB    1 
ATOM   501  N  N     . CYS A 1 100 ? 34.06300 -3.06000  19.50300  1.000 52.54550  ? 1516 CYS A N     1 
ATOM   502  C  CA    . CYS A 1 100 ? 33.85600 -4.09600  18.50200  1.000 53.40488  ? 1516 CYS A CA    1 
ATOM   503  C  C     . CYS A 1 100 ? 33.97300 -3.46600  17.11100  1.000 54.14664  ? 1516 CYS A C     1 
ATOM   504  O  O     . CYS A 1 100 ? 33.06200 -3.51100  16.29200  1.000 50.25702  ? 1516 CYS A O     1 
ATOM   505  C  CB    . CYS A 1 100 ? 32.50600 -4.80700  18.71400  1.000 54.64014  ? 1516 CYS A CB    1 
ATOM   506  S  SG    . CYS A 1 100 ? 32.33100 -5.82400  20.26200  1.000 45.48290  ? 1516 CYS A SG    1 
ATOM   507  N  N     . GLY A 1 101 ? 35.11000 -2.82000  16.88600  1.000 55.54992  ? 1517 GLY A N     1 
ATOM   508  C  CA    . GLY A 1 101 ? 35.37900 -2.17300  15.62200  1.000 52.75953  ? 1517 GLY A CA    1 
ATOM   509  C  C     . GLY A 1 101 ? 35.86700 -3.16500  14.59400  1.000 53.36541  ? 1517 GLY A C     1 
ATOM   510  O  O     . GLY A 1 101 ? 35.40100 -4.31000  14.55000  1.000 55.19383  ? 1517 GLY A O     1 
ATOM   511  N  N     . GLU A 1 102 ? 36.83900 -2.74800  13.78500  1.000 60.87357  ? 1518 GLU A N     1 
ATOM   512  C  CA    . GLU A 1 102 ? 37.21400 -3.54700  12.63000  1.000 66.24275  ? 1518 GLU A CA    1 
ATOM   513  C  C     . GLU A 1 102 ? 37.91600 -4.83700  13.02600  1.000 68.36048  ? 1518 GLU A C     1 
ATOM   514  O  O     . GLU A 1 102 ? 37.92600 -5.78900  12.23300  1.000 68.83870  ? 1518 GLU A O     1 
ATOM   515  C  CB    . GLU A 1 102 ? 38.10400 -2.72900  11.68900  1.000 73.35593  ? 1518 GLU A CB    1 
ATOM   516  C  CG    . GLU A 1 102 ? 39.51700 -2.47900  12.21800  1.000 88.78319  ? 1518 GLU A CG    1 
ATOM   517  C  CD    . GLU A 1 102 ? 40.25700 -1.39400  11.45200  1.000 103.06385 ? 1518 GLU A CD    1 
ATOM   518  O  OE1   . GLU A 1 102 ? 39.75100 -0.25300  11.39900  1.000 109.43040 ? 1518 GLU A OE1   1 
ATOM   519  O  OE2   . GLU A 1 102 ? 41.34500 -1.67800  10.90500  1.000 107.21172 ? 1518 GLU A OE2   1 
ATOM   520  N  N     . ASP A 1 103 ? 38.49500 -4.90000  14.22600  1.000 66.53456  ? 1519 ASP A N     1 
ATOM   521  C  CA    . ASP A 1 103 ? 39.23400 -6.08300  14.65000  1.000 64.09164  ? 1519 ASP A CA    1 
ATOM   522  C  C     . ASP A 1 103 ? 38.38900 -7.03200  15.48900  1.000 62.92741  ? 1519 ASP A C     1 
ATOM   523  O  O     . ASP A 1 103 ? 38.92500 -7.99000  16.05700  1.000 65.21194  ? 1519 ASP A O     1 
ATOM   524  C  CB    . ASP A 1 103 ? 40.49900 -5.67300  15.40300  1.000 66.91524  ? 1519 ASP A CB    1 
ATOM   525  C  CG    . ASP A 1 103 ? 41.45400 -4.86800  14.53300  1.000 78.54730  ? 1519 ASP A CG    1 
ATOM   526  O  OD1   . ASP A 1 103 ? 41.61500 -5.22000  13.34500  1.000 81.35052  ? 1519 ASP A OD1   1 
ATOM   527  O  OD2   . ASP A 1 103 ? 42.04700 -3.88400  15.03200  1.000 85.32858  ? 1519 ASP A OD2   1 
ATOM   528  N  N     . CYS A 1 104 ? 37.07900 -6.80500  15.55800  1.000 61.36855  ? 1520 CYS A N     1 
ATOM   529  C  CA    . CYS A 1 104 ? 36.21800 -7.66900  16.35000  1.000 56.30635  ? 1520 CYS A CA    1 
ATOM   530  C  C     . CYS A 1 104 ? 36.00600 -8.99300  15.62800  1.000 60.63255  ? 1520 CYS A C     1 
ATOM   531  O  O     . CYS A 1 104 ? 35.50900 -9.01900  14.49900  1.000 59.70431  ? 1520 CYS A O     1 
ATOM   532  C  CB    . CYS A 1 104 ? 34.87900 -6.99100  16.60100  1.000 51.81344  ? 1520 CYS A CB    1 
ATOM   533  S  SG    . CYS A 1 104 ? 33.68400 -8.14600  17.23600  1.000 50.57571  ? 1520 CYS A SG    1 
ATOM   534  N  N     . LEU A 1 105 ? 36.34900 -10.09600 16.29800  1.000 61.94835  ? 1521 LEU A N     1 
ATOM   535  C  CA    . LEU A 1 105 ? 36.24300 -11.41000 15.67900  1.000 63.87591  ? 1521 LEU A CA    1 
ATOM   536  C  C     . LEU A 1 105 ? 34.82000 -11.70900 15.21100  1.000 65.35171  ? 1521 LEU A C     1 
ATOM   537  O  O     . LEU A 1 105 ? 34.64200 -12.29800 14.14000  1.000 64.81192  ? 1521 LEU A O     1 
ATOM   538  C  CB    . LEU A 1 105 ? 36.75400 -12.49600 16.64100  1.000 65.86786  ? 1521 LEU A CB    1 
ATOM   539  C  CG    . LEU A 1 105 ? 36.59300 -13.94300 16.11400  1.000 82.44559  ? 1521 LEU A CG    1 
ATOM   540  C  CD1   . LEU A 1 105 ? 37.85900 -14.78700 16.31400  1.000 92.10991  ? 1521 LEU A CD1   1 
ATOM   541  C  CD2   . LEU A 1 105 ? 35.38900 -14.66100 16.73500  1.000 84.82482  ? 1521 LEU A CD2   1 
ATOM   542  N  N     . ASN A 1 106 ? 33.79600 -11.30200 15.96800  1.000 63.87109  ? 1522 ASN A N     1 
ATOM   543  C  CA    . ASN A 1 106 ? 32.43100 -11.51400 15.49600  1.000 59.48248  ? 1522 ASN A CA    1 
ATOM   544  C  C     . ASN A 1 106 ? 32.19300 -10.77300 14.18900  1.000 57.34521  ? 1522 ASN A C     1 
ATOM   545  O  O     . ASN A 1 106 ? 31.71000 -11.35700 13.21200  1.000 60.73509  ? 1522 ASN A O     1 
ATOM   546  C  CB    . ASN A 1 106 ? 31.41100 -11.07900 16.55400  1.000 58.73917  ? 1522 ASN A CB    1 
ATOM   547  C  CG    . ASN A 1 106 ? 31.10900 -12.18000 17.57100  1.000 65.35628  ? 1522 ASN A CG    1 
ATOM   548  O  OD1   . ASN A 1 106 ? 31.41800 -13.34300 17.33500  1.000 73.30997  ? 1522 ASN A OD1   1 
ATOM   549  N  ND2   . ASN A 1 106 ? 30.50900 -11.80800 18.71500  1.000 66.38666  ? 1522 ASN A ND2   1 
ATOM   550  N  N     . ARG A 1 107 ? 32.53500 -9.48200  14.15100  1.000 55.53267  ? 1523 ARG A N     1 
ATOM   551  C  CA    . ARG A 1 107 ? 32.32800 -8.69100  12.94100  1.000 56.60810  ? 1523 ARG A CA    1 
ATOM   552  C  C     . ARG A 1 107 ? 33.06600 -9.30500  11.75600  1.000 57.31502  ? 1523 ARG A C     1 
ATOM   553  O  O     . ARG A 1 107 ? 32.47400 -9.52900  10.69600  1.000 54.28057  ? 1523 ARG A O     1 
ATOM   554  C  CB    . ARG A 1 107 ? 32.77300 -7.24800  13.18600  1.000 50.97214  ? 1523 ARG A CB    1 
ATOM   555  C  CG    . ARG A 1 107 ? 32.73400 -6.33700  11.97400  1.000 51.36488  ? 1523 ARG A CG    1 
ATOM   556  C  CD    . ARG A 1 107 ? 33.35300 -4.97200  12.28600  1.000 51.96645  ? 1523 ARG A CD    1 
ATOM   557  N  NE    . ARG A 1 107 ? 32.63800 -4.28000  13.35500  1.000 52.29197  ? 1523 ARG A NE    1 
ATOM   558  C  CZ    . ARG A 1 107 ? 31.56200 -3.52100  13.16100  1.000 54.85413  ? 1523 ARG A CZ    1 
ATOM   559  N  NH1   . ARG A 1 107 ? 31.08400 -3.34900  11.93300  1.000 49.35720  ? 1523 ARG A NH1   1 
ATOM   560  N  NH2   . ARG A 1 107 ? 30.97700 -2.91300  14.19000  1.000 48.64190  ? 1523 ARG A NH2   1 
ATOM   561  N  N     . LEU A 1 108 ? 34.35000 -9.64100  11.94200  1.000 58.98913  ? 1524 LEU A N     1 
ATOM   562  C  CA    . LEU A 1 108 ? 35.16600 -10.20100 10.86800  1.000 61.25242  ? 1524 LEU A CA    1 
ATOM   563  C  C     . LEU A 1 108 ? 34.56300 -11.45300 10.25100  1.000 58.91645  ? 1524 LEU A C     1 
ATOM   564  O  O     . LEU A 1 108 ? 34.94700 -11.83000 9.13900   1.000 59.53495  ? 1524 LEU A O     1 
ATOM   565  C  CB    . LEU A 1 108 ? 36.56500 -10.54300 11.37700  1.000 59.34878  ? 1524 LEU A CB    1 
ATOM   566  C  CG    . LEU A 1 108 ? 37.42400 -9.36900  11.84000  1.000 67.92543  ? 1524 LEU A CG    1 
ATOM   567  C  CD1   . LEU A 1 108 ? 38.25900 -9.76100  13.04900  1.000 73.70244  ? 1524 LEU A CD1   1 
ATOM   568  C  CD2   . LEU A 1 108 ? 38.31600 -8.88300  10.70000  1.000 64.13813  ? 1524 LEU A CD2   1 
ATOM   569  N  N     . LEU A 1 109 ? 33.66400 -12.12800 10.95400  1.000 58.39396  ? 1525 LEU A N     1 
ATOM   570  C  CA    . LEU A 1 109 ? 32.98500 -13.29300 10.41600  1.000 53.56318  ? 1525 LEU A CA    1 
ATOM   571  C  C     . LEU A 1 109 ? 31.54600 -12.98100 10.06600  1.000 52.10780  ? 1525 LEU A C     1 
ATOM   572  O  O     . LEU A 1 109 ? 30.77200 -13.90300 9.81500   1.000 50.87075  ? 1525 LEU A O     1 
ATOM   573  C  CB    . LEU A 1 109 ? 33.02900 -14.45300 11.41100  1.000 57.50313  ? 1525 LEU A CB    1 
ATOM   574  C  CG    . LEU A 1 109 ? 34.30800 -15.25800 11.58900  1.000 62.99326  ? 1525 LEU A CG    1 
ATOM   575  C  CD1   . LEU A 1 109 ? 34.10800 -16.23000 12.72300  1.000 69.93620  ? 1525 LEU A CD1   1 
ATOM   576  C  CD2   . LEU A 1 109 ? 34.66700 -16.00800 10.33200  1.000 61.10823  ? 1525 LEU A CD2   1 
ATOM   577  N  N     . MET A 1 110 ? 31.16100 -11.71000 10.09000  1.000 53.64586  ? 1526 MET A N     1 
ATOM   578  C  CA    . MET A 1 110 ? 29.79800 -11.30800 9.74400   1.000 51.24005  ? 1526 MET A CA    1 
ATOM   579  C  C     . MET A 1 110 ? 28.79500 -11.97700 10.69000  1.000 49.62587  ? 1526 MET A C     1 
ATOM   580  O  O     . MET A 1 110 ? 27.79300 -12.57700 10.28200  1.000 46.91677  ? 1526 MET A O     1 
ATOM   581  C  CB    . MET A 1 110 ? 29.51600 -11.59500 8.25800   1.000 46.76411  ? 1526 MET A CB    1 
ATOM   582  C  CG    . MET A 1 110 ? 30.48500 -10.79900 7.38700   1.000 51.08337  ? 1526 MET A CG    1 
ATOM   583  S  SD    . MET A 1 110 ? 30.32700 -10.91900 5.59600   1.000 62.65901  ? 1526 MET A SD    1 
ATOM   584  C  CE    . MET A 1 110 ? 28.57400 -10.69500 5.45000   1.000 61.79575  ? 1526 MET A CE    1 
ATOM   585  N  N     . ILE A 1 111 ? 29.11300 -11.88100 11.97900  1.000 48.02831  ? 1527 ILE A N     1 
ATOM   586  C  CA    . ILE A 1 111 ? 28.26500 -12.31100 13.08500  1.000 50.77321  ? 1527 ILE A CA    1 
ATOM   587  C  C     . ILE A 1 111 ? 28.06600 -11.10400 13.98000  1.000 49.92330  ? 1527 ILE A C     1 
ATOM   588  O  O     . ILE A 1 111 ? 29.03300 -10.40600 14.29500  1.000 42.39003  ? 1527 ILE A O     1 
ATOM   589  C  CB    . ILE A 1 111 ? 28.90900 -13.45300 13.89300  1.000 52.63488  ? 1527 ILE A CB    1 
ATOM   590  C  CG1   . ILE A 1 111 ? 29.17500 -14.67100 13.00700  1.000 52.48819  ? 1527 ILE A CG1   1 
ATOM   591  C  CG2   . ILE A 1 111 ? 28.05800 -13.79400 15.10800  1.000 49.22319  ? 1527 ILE A CG2   1 
ATOM   592  C  CD1   . ILE A 1 111 ? 30.02100 -15.74900 13.69300  1.000 56.25130  ? 1527 ILE A CD1   1 
ATOM   593  N  N     . GLU A 1 112 ? 26.83100 -10.84000 14.37400  1.000 46.88850  ? 1528 GLU A N     1 
ATOM   594  C  CA    . GLU A 1 112 ? 26.60300 -9.72000  15.27400  1.000 50.73370  ? 1528 GLU A CA    1 
ATOM   595  C  C     . GLU A 1 112 ? 26.77000 -10.15800 16.72800  1.000 50.56017  ? 1528 GLU A C     1 
ATOM   596  O  O     . GLU A 1 112 ? 26.51200 -11.30900 17.09100  1.000 44.06616  ? 1528 GLU A O     1 
ATOM   597  C  CB    . GLU A 1 112 ? 25.21800 -9.11600  15.04700  1.000 43.90476  ? 1528 GLU A CB    1 
ATOM   598  C  CG    . GLU A 1 112 ? 25.14800 -8.26800  13.78200  1.000 45.28121  ? 1528 GLU A CG    1 
ATOM   599  C  CD    . GLU A 1 112 ? 24.16200 -7.12100  13.88200  1.000 47.38349  ? 1528 GLU A CD    1 
ATOM   600  O  OE1   . GLU A 1 112 ? 23.20700 -7.21400  14.69100  1.000 47.12460  ? 1528 GLU A OE1   1 
ATOM   601  O  OE2   . GLU A 1 112 ? 24.35100 -6.11400  13.15700  1.000 46.67151  ? 1528 GLU A OE2   1 
ATOM   602  N  N     . CYS A 1 113 ? 27.23600 -9.22900  17.54700  1.000 51.22577  ? 1529 CYS A N     1 
ATOM   603  C  CA    . CYS A 1 113 ? 27.31900 -9.48600  18.97500  1.000 50.69178  ? 1529 CYS A CA    1 
ATOM   604  C  C     . CYS A 1 113 ? 25.93200 -9.50200  19.59800  1.000 48.31934  ? 1529 CYS A C     1 
ATOM   605  O  O     . CYS A 1 113 ? 24.97100 -8.93600  19.07300  1.000 50.46263  ? 1529 CYS A O     1 
ATOM   606  C  CB    . CYS A 1 113 ? 28.18200 -8.43800  19.66400  1.000 47.82866  ? 1529 CYS A CB    1 
ATOM   607  S  SG    . CYS A 1 113 ? 29.88900 -8.50000  19.16300  1.000 48.37394  ? 1529 CYS A SG    1 
ATOM   608  N  N     . SER A 1 114 ? 25.83400 -10.16800 20.73200  1.000 48.95198  ? 1530 SER A N     1 
ATOM   609  C  CA    . SER A 1 114 ? 24.59100 -10.23200 21.47100  1.000 51.93290  ? 1530 SER A CA    1 
ATOM   610  C  C     . SER A 1 114 ? 24.60000 -9.19100  22.57900  1.000 50.50492  ? 1530 SER A C     1 
ATOM   611  O  O     . SER A 1 114 ? 25.55400 -8.42700  22.75700  1.000 49.03895  ? 1530 SER A O     1 
ATOM   612  C  CB    . SER A 1 114 ? 24.39300 -11.61700 22.08200  1.000 56.70469  ? 1530 SER A CB    1 
ATOM   613  O  OG    . SER A 1 114 ? 25.26300 -11.74600 23.18000  1.000 52.61069  ? 1530 SER A OG    1 
ATOM   614  N  N     . SER A 1 115 ? 23.52900 -9.19900  23.37200  1.000 50.87932  ? 1531 SER A N     1 
ATOM   615  C  CA    . SER A 1 115 ? 23.48100 -8.33900  24.55000  1.000 55.15267  ? 1531 SER A CA    1 
ATOM   616  C  C     . SER A 1 115 ? 24.61100 -8.66100  25.52400  1.000 53.54739  ? 1531 SER A C     1 
ATOM   617  O  O     . SER A 1 115 ? 25.05600 -7.78700  26.26700  1.000 51.83622  ? 1531 SER A O     1 
ATOM   618  C  CB    . SER A 1 115 ? 22.13500 -8.50000  25.23800  1.000 52.64252  ? 1531 SER A CB    1 
ATOM   619  O  OG    . SER A 1 115 ? 22.03400 -9.81100  25.77600  1.000 55.88884  ? 1531 SER A OG    1 
ATOM   620  N  N     . ARG A 1 116 ? 25.10700 -9.89500  25.51300  1.000 53.90269  ? 1532 ARG A N     1 
ATOM   621  C  CA    . ARG A 1 116 ? 26.17000 -10.32100 26.41300  1.000 58.37011  ? 1532 ARG A CA    1 
ATOM   622  C  C     . ARG A 1 116 ? 27.57500 -9.92800  25.93200  1.000 61.13171  ? 1532 ARG A C     1 
ATOM   623  O  O     . ARG A 1 116 ? 28.55500 -10.30700 26.58200  1.000 59.03830  ? 1532 ARG A O     1 
ATOM   624  C  CB    . ARG A 1 116 ? 26.08000 -11.84100 26.62900  1.000 58.48918  ? 1532 ARG A CB    1 
ATOM   625  C  CG    . ARG A 1 116 ? 24.90300 -12.27000 27.51200  1.000 67.72404  ? 1532 ARG A CG    1 
ATOM   626  C  CD    . ARG A 1 116 ? 24.44200 -13.69500 27.21900  1.000 84.99288  ? 1532 ARG A CD    1 
ATOM   627  N  NE    . ARG A 1 116 ? 23.11200 -13.97500 27.77000  1.000 95.47859  ? 1532 ARG A NE    1 
ATOM   628  C  CZ    . ARG A 1 116 ? 22.85000 -14.88200 28.71200  1.000 104.04121 ? 1532 ARG A CZ    1 
ATOM   629  N  NH1   . ARG A 1 116 ? 23.83000 -15.61300 29.23600  1.000 106.82647 ? 1532 ARG A NH1   1 
ATOM   630  N  NH2   . ARG A 1 116 ? 21.60000 -15.06200 29.13200  1.000 108.78822 ? 1532 ARG A NH2   1 
ATOM   631  N  N     . CYS A 1 117 ? 27.70200 -9.17300  24.83700  1.000 57.34825  ? 1533 CYS A N     1 
ATOM   632  C  CA    . CYS A 1 117 ? 29.02200 -8.82300  24.31600  1.000 61.30692  ? 1533 CYS A CA    1 
ATOM   633  C  C     . CYS A 1 117 ? 29.86400 -8.16100  25.40400  1.000 60.15870  ? 1533 CYS A C     1 
ATOM   634  O  O     . CYS A 1 117 ? 29.34400 -7.34300  26.16000  1.000 54.17183  ? 1533 CYS A O     1 
ATOM   635  C  CB    . CYS A 1 117 ? 28.90600 -7.86300  23.13100  1.000 50.03686  ? 1533 CYS A CB    1 
ATOM   636  S  SG    . CYS A 1 117 ? 30.39600 -6.88400  22.93600  1.000 50.35824  ? 1533 CYS A SG    1 
ATOM   637  N  N     . PRO A 1 118 ? 31.16400 -8.46200  25.49000  1.000 62.59005  ? 1534 PRO A N     1 
ATOM   638  C  CA    . PRO A 1 118 ? 31.98200 -7.84300  26.54500  1.000 61.00659  ? 1534 PRO A CA    1 
ATOM   639  C  C     . PRO A 1 118 ? 31.90300 -6.32300  26.56600  1.000 63.51824  ? 1534 PRO A C     1 
ATOM   640  O  O     . PRO A 1 118 ? 32.11000 -5.71800  27.62400  1.000 56.76949  ? 1534 PRO A O     1 
ATOM   641  C  CB    . PRO A 1 118 ? 33.40100 -8.33600  26.22300  1.000 64.57510  ? 1534 PRO A CB    1 
ATOM   642  C  CG    . PRO A 1 118 ? 33.35300 -8.69200  24.74400  1.000 63.17490  ? 1534 PRO A CG    1 
ATOM   643  C  CD    . PRO A 1 118 ? 31.98100 -9.26100  24.55500  1.000 64.29833  ? 1534 PRO A CD    1 
ATOM   644  N  N     . ASN A 1 119 ? 31.57700 -5.68400  25.44600  1.000 58.37280  ? 1535 ASN A N     1 
ATOM   645  C  CA    . ASN A 1 119 ? 31.46000 -4.22900  25.38500  1.000 55.73186  ? 1535 ASN A CA    1 
ATOM   646  C  C     . ASN A 1 119 ? 30.06100 -3.72600  25.71000  1.000 57.00043  ? 1535 ASN A C     1 
ATOM   647  O  O     . ASN A 1 119 ? 29.86000 -2.50900  25.78700  1.000 62.85377  ? 1535 ASN A O     1 
ATOM   648  C  CB    . ASN A 1 119 ? 31.87400 -3.71500  23.99600  1.000 64.86190  ? 1535 ASN A CB    1 
ATOM   649  C  CG    . ASN A 1 119 ? 33.36400 -3.43700  23.89600  1.000 67.64908  ? 1535 ASN A CG    1 
ATOM   650  O  OD1   . ASN A 1 119 ? 33.93100 -2.74200  24.73400  1.000 64.51186  ? 1535 ASN A OD1   1 
ATOM   651  N  ND2   . ASN A 1 119 ? 34.00500 -3.99000  22.87400  1.000 73.52873  ? 1535 ASN A ND2   1 
ATOM   652  N  N     . GLY A 1 120 ? 29.09800 -4.61800  25.88600  1.000 58.07688  ? 1536 GLY A N     1 
ATOM   653  C  CA    . GLY A 1 120 ? 27.81100 -4.20800  26.43000  1.000 60.08501  ? 1536 GLY A CA    1 
ATOM   654  C  C     . GLY A 1 120 ? 27.11700 -3.19400  25.54400  1.000 61.42766  ? 1536 GLY A C     1 
ATOM   655  O  O     . GLY A 1 120 ? 27.00300 -3.36800  24.31600  1.000 53.08139  ? 1536 GLY A O     1 
ATOM   656  N  N     . ASP A 1 121 ? 26.65700 -2.10800  26.17200  1.000 53.65352  ? 1537 ASP A N     1 
ATOM   657  C  CA    . ASP A 1 121 ? 25.88900 -1.10900  25.43900  1.000 58.46762  ? 1537 ASP A CA    1 
ATOM   658  C  C     . ASP A 1 121 ? 26.72700 -0.41500  24.37500  1.000 52.65944  ? 1537 ASP A C     1 
ATOM   659  O  O     . ASP A 1 121 ? 26.17400 0.06900   23.39000  1.000 52.43114  ? 1537 ASP A O     1 
ATOM   660  C  CB    . ASP A 1 121 ? 25.30800 -0.05900  26.38800  1.000 60.41158  ? 1537 ASP A CB    1 
ATOM   661  C  CG    . ASP A 1 121 ? 24.63000 -0.66500  27.60100  1.000 73.81561  ? 1537 ASP A CG    1 
ATOM   662  O  OD1   . ASP A 1 121 ? 23.56700 -1.29500  27.42500  1.000 83.21147  ? 1537 ASP A OD1   1 
ATOM   663  O  OD2   . ASP A 1 121 ? 25.14800 -0.49200  28.73000  1.000 76.34223  ? 1537 ASP A OD2   1 
ATOM   664  N  N     . TYR A 1 122 ? 28.05300 -0.35400  24.56000  1.000 53.92901  ? 1538 TYR A N     1 
ATOM   665  C  CA    . TYR A 1 122 ? 28.95800 0.31800   23.62800  1.000 55.18906  ? 1538 TYR A CA    1 
ATOM   666  C  C     . TYR A 1 122 ? 29.08700 -0.39600  22.27300  1.000 55.44171  ? 1538 TYR A C     1 
ATOM   667  O  O     . TYR A 1 122 ? 29.48600 0.23900   21.28700  1.000 52.73676  ? 1538 TYR A O     1 
ATOM   668  C  CB    . TYR A 1 122 ? 30.35900 0.41200   24.22800  1.000 59.60270  ? 1538 TYR A CB    1 
ATOM   669  C  CG    . TYR A 1 122 ? 30.53900 1.27800   25.46100  1.000 65.11296  ? 1538 TYR A CG    1 
ATOM   670  C  CD1   . TYR A 1 122 ? 29.68000 2.32900   25.75500  1.000 63.84854  ? 1538 TYR A CD1   1 
ATOM   671  C  CD2   . TYR A 1 122 ? 31.60600 1.04600   26.32400  1.000 70.88309  ? 1538 TYR A CD2   1 
ATOM   672  C  CE1   . TYR A 1 122 ? 29.87600 3.12000   26.90400  1.000 71.22367  ? 1538 TYR A CE1   1 
ATOM   673  C  CE2   . TYR A 1 122 ? 31.81600 1.82200   27.45000  1.000 73.50509  ? 1538 TYR A CE2   1 
ATOM   674  C  CZ    . TYR A 1 122 ? 30.95300 2.85800   27.73900  1.000 74.28098  ? 1538 TYR A CZ    1 
ATOM   675  O  OH    . TYR A 1 122 ? 31.19400 3.60700   28.87400  1.000 78.68319  ? 1538 TYR A OH    1 
ATOM   676  N  N     . CYS A 1 123 ? 28.80000 -1.69400  22.21100  1.000 51.01137  ? 1539 CYS A N     1 
ATOM   677  C  CA    . CYS A 1 123 ? 29.15400 -2.50300  21.04900  1.000 53.25078  ? 1539 CYS A CA    1 
ATOM   678  C  C     . CYS A 1 123 ? 28.56900 -1.93400  19.76900  1.000 49.35741  ? 1539 CYS A C     1 
ATOM   679  O  O     . CYS A 1 123 ? 27.35300 -1.79800  19.64600  1.000 44.93705  ? 1539 CYS A O     1 
ATOM   680  C  CB    . CYS A 1 123 ? 28.65500 -3.92700  21.25400  1.000 54.70469  ? 1539 CYS A CB    1 
ATOM   681  S  SG    . CYS A 1 123 ? 28.86200 -4.92900  19.77000  1.000 46.11061  ? 1539 CYS A SG    1 
ATOM   682  N  N     . SER A 1 124 ? 29.42900 -1.62600  18.80500  1.000 52.40778  ? 1540 SER A N     1 
ATOM   683  C  CA    . SER A 1 124 ? 28.97900 -1.08300  17.53100  1.000 50.10487  ? 1540 SER A CA    1 
ATOM   684  C  C     . SER A 1 124 ? 28.66000 -2.18000  16.50800  1.000 48.29244  ? 1540 SER A C     1 
ATOM   685  O  O     . SER A 1 124 ? 28.40700 -1.87200  15.33800  1.000 50.44807  ? 1540 SER A O     1 
ATOM   686  C  CB    . SER A 1 124 ? 30.03000 -0.13400  16.94200  1.000 50.19873  ? 1540 SER A CB    1 
ATOM   687  O  OG    . SER A 1 124 ? 31.14300 -0.85400  16.45400  1.000 48.85060  ? 1540 SER A OG    1 
ATOM   688  N  N     . ASN A 1 125 ? 28.68300 -3.44700  16.91600  1.000 47.83392  ? 1541 ASN A N     1 
ATOM   689  C  CA    . ASN A 1 125 ? 28.45500 -4.58500  16.02800  1.000 47.70005  ? 1541 ASN A CA    1 
ATOM   690  C  C     . ASN A 1 125 ? 27.08600 -5.21300  16.26700  1.000 44.68222  ? 1541 ASN A C     1 
ATOM   691  O  O     . ASN A 1 125 ? 26.92600 -6.43000  16.24900  1.000 46.88073  ? 1541 ASN A O     1 
ATOM   692  C  CB    . ASN A 1 125 ? 29.55500 -5.62800  16.19200  1.000 44.11118  ? 1541 ASN A CB    1 
ATOM   693  C  CG    . ASN A 1 125 ? 29.45700 -6.75700  15.16000  1.000 50.07329  ? 1541 ASN A CG    1 
ATOM   694  O  OD1   . ASN A 1 125 ? 28.95600 -6.55600  14.03900  1.000 42.55396  ? 1541 ASN A OD1   1 
ATOM   695  N  ND2   . ASN A 1 125 ? 29.91000 -7.95500  15.54500  1.000 44.84635  ? 1541 ASN A ND2   1 
ATOM   696  N  N     . ARG A 1 126 ? 26.07100 -4.38500  16.49100  1.000 44.62789  ? 1542 ARG A N     1 
ATOM   697  C  CA    . ARG A 1 126 ? 24.69700 -4.86400  16.62200  1.000 46.01945  ? 1542 ARG A CA    1 
ATOM   698  C  C     . ARG A 1 126 ? 23.76900 -4.04300  15.71800  1.000 44.58870  ? 1542 ARG A C     1 
ATOM   699  O  O     . ARG A 1 126 ? 22.60800 -3.78000  16.06100  1.000 45.10326  ? 1542 ARG A O     1 
ATOM   700  C  CB    . ARG A 1 126 ? 24.25500 -4.83000  18.09800  1.000 48.88213  ? 1542 ARG A CB    1 
ATOM   701  C  CG    . ARG A 1 126 ? 25.27300 -5.47700  19.07400  1.000 44.57883  ? 1542 ARG A CG    1 
ATOM   702  C  CD    . ARG A 1 126 ? 24.70300 -5.72300  20.50400  1.000 51.09042  ? 1542 ARG A CD    1 
ATOM   703  N  NE    . ARG A 1 126 ? 23.58700 -6.65600  20.44400  1.000 51.38134  ? 1542 ARG A NE    1 
ATOM   704  C  CZ    . ARG A 1 126 ? 22.55700 -6.65300  21.27600  1.000 49.36531  ? 1542 ARG A CZ    1 
ATOM   705  N  NH1   . ARG A 1 126 ? 22.49700 -5.77300  22.26900  1.000 48.32579  ? 1542 ARG A NH1   1 
ATOM   706  N  NH2   . ARG A 1 126 ? 21.59100 -7.55200  21.12100  1.000 46.81237  ? 1542 ARG A NH2   1 
ATOM   707  N  N     . ARG A 1 127 ? 24.28200 -3.63900  14.54800  1.000 44.63799  ? 1543 ARG A N     1 
ATOM   708  C  CA    . ARG A 1 127 ? 23.56500 -2.71700  13.66800  1.000 45.94430  ? 1543 ARG A CA    1 
ATOM   709  C  C     . ARG A 1 127 ? 22.23100 -3.29600  13.21000  1.000 44.96150  ? 1543 ARG A C     1 
ATOM   710  O  O     . ARG A 1 127 ? 21.20300 -2.60800  13.23400  1.000 44.38675  ? 1543 ARG A O     1 
ATOM   711  C  CB    . ARG A 1 127 ? 24.44500 -2.36000  12.47000  1.000 47.82502  ? 1543 ARG A CB    1 
ATOM   712  C  CG    . ARG A 1 127 ? 25.63700 -1.49200  12.87100  1.000 48.95213  ? 1543 ARG A CG    1 
ATOM   713  C  CD    . ARG A 1 127 ? 26.70500 -1.49000  11.79500  1.000 45.84338  ? 1543 ARG A CD    1 
ATOM   714  N  NE    . ARG A 1 127 ? 27.14900 -2.83600  11.44800  1.000 48.30454  ? 1543 ARG A NE    1 
ATOM   715  C  CZ    . ARG A 1 127 ? 27.92700 -3.09600  10.39900  1.000 51.39871  ? 1543 ARG A CZ    1 
ATOM   716  N  NH1   . ARG A 1 127 ? 28.32600 -2.10600  9.59900   1.000 50.04960  ? 1543 ARG A NH1   1 
ATOM   717  N  NH2   . ARG A 1 127 ? 28.30100 -4.34000  10.13600  1.000 50.11923  ? 1543 ARG A NH2   1 
ATOM   718  N  N     . PHE A 1 128 ? 22.21800 -4.56400  12.80800  1.000 45.14210  ? 1544 PHE A N     1 
ATOM   719  C  CA    . PHE A 1 128 ? 20.96100 -5.19000  12.40800  1.000 46.81240  ? 1544 PHE A CA    1 
ATOM   720  C  C     . PHE A 1 128 ? 19.97000 -5.18100  13.56700  1.000 43.37875  ? 1544 PHE A C     1 
ATOM   721  O  O     . PHE A 1 128 ? 18.81100 -4.78100  13.40900  1.000 45.47412  ? 1544 PHE A O     1 
ATOM   722  C  CB    . PHE A 1 128 ? 21.20000 -6.63100  11.93600  1.000 45.54996  ? 1544 PHE A CB    1 
ATOM   723  C  CG    . PHE A 1 128 ? 21.70200 -6.78200  10.50000  1.000 50.67007  ? 1544 PHE A CG    1 
ATOM   724  C  CD1   . PHE A 1 128 ? 23.05500 -6.73800  10.21600  1.000 47.56434  ? 1544 PHE A CD1   1 
ATOM   725  C  CD2   . PHE A 1 128 ? 20.83000 -7.09600  9.47300   1.000 43.77164  ? 1544 PHE A CD2   1 
ATOM   726  C  CE1   . PHE A 1 128 ? 23.53100 -6.94000  8.92100   1.000 48.35458  ? 1544 PHE A CE1   1 
ATOM   727  C  CE2   . PHE A 1 128 ? 21.29700 -7.31800  8.16800   1.000 45.80545  ? 1544 PHE A CE2   1 
ATOM   728  C  CZ    . PHE A 1 128 ? 22.65100 -7.23300  7.89700   1.000 46.56701  ? 1544 PHE A CZ    1 
ATOM   729  N  N     . GLN A 1 129 ? 20.41000 -5.62700  14.74400  1.000 42.52535  ? 1545 GLN A N     1 
ATOM   730  C  CA    . GLN A 1 129 ? 19.49400 -5.75000  15.88100  1.000 47.63639  ? 1545 GLN A CA    1 
ATOM   731  C  C     . GLN A 1 129 ? 18.99000 -4.39500  16.34300  1.000 45.79810  ? 1545 GLN A C     1 
ATOM   732  O  O     . GLN A 1 129 ? 17.80300 -4.23800  16.66200  1.000 46.59225  ? 1545 GLN A O     1 
ATOM   733  C  CB    . GLN A 1 129 ? 20.18600 -6.46300  17.03600  1.000 46.62175  ? 1545 GLN A CB    1 
ATOM   734  C  CG    . GLN A 1 129 ? 20.38900 -7.92400  16.79600  1.000 50.54467  ? 1545 GLN A CG    1 
ATOM   735  C  CD    . GLN A 1 129 ? 21.47700 -8.48200  17.65100  1.000 47.70638  ? 1545 GLN A CD    1 
ATOM   736  O  OE1   . GLN A 1 129 ? 21.22400 -8.96300  18.76100  1.000 52.13223  ? 1545 GLN A OE1   1 
ATOM   737  N  NE2   . GLN A 1 129 ? 22.71000 -8.38700  17.17000  1.000 45.95801  ? 1545 GLN A NE2   1 
ATOM   738  N  N     . ARG A 1 130 ? 19.87800 -3.40300  16.39100  1.000 44.38642  ? 1546 ARG A N     1 
ATOM   739  C  CA    . ARG A 1 130 ? 19.49400 -2.06500  16.82400  1.000 45.75804  ? 1546 ARG A CA    1 
ATOM   740  C  C     . ARG A 1 130 ? 18.87100 -1.23400  15.70700  1.000 51.44783  ? 1546 ARG A C     1 
ATOM   741  O  O     . ARG A 1 130 ? 18.38100 -0.13800  15.97900  1.000 48.75911  ? 1546 ARG A O     1 
ATOM   742  C  CB    . ARG A 1 130 ? 20.70900 -1.35000  17.41900  1.000 45.80864  ? 1546 ARG A CB    1 
ATOM   743  C  CG    . ARG A 1 130 ? 21.19700 -2.01400  18.72400  1.000 41.91261  ? 1546 ARG A CG    1 
ATOM   744  C  CD    . ARG A 1 130 ? 22.31600 -1.21900  19.42400  1.000 44.98584  ? 1546 ARG A CD    1 
ATOM   745  N  NE    . ARG A 1 130 ? 22.64300 -1.81100  20.72000  1.000 50.79254  ? 1546 ARG A NE    1 
ATOM   746  C  CZ    . ARG A 1 130 ? 21.90300 -1.64000  21.80300  1.000 46.60068  ? 1546 ARG A CZ    1 
ATOM   747  N  NH1   . ARG A 1 130 ? 20.83100 -0.87400  21.73900  1.000 41.12955  ? 1546 ARG A NH1   1 
ATOM   748  N  NH2   . ARG A 1 130 ? 22.23900 -2.21900  22.94900  1.000 44.28930  ? 1546 ARG A NH2   1 
ATOM   749  N  N     . LYS A 1 131 ? 18.85700 -1.73200  14.46900  1.000 49.68476  ? 1547 LYS A N     1 
ATOM   750  C  CA    . LYS A 1 131 ? 18.21200 -1.02700  13.36800  1.000 50.00887  ? 1547 LYS A CA    1 
ATOM   751  C  C     . LYS A 1 131 ? 18.91200 0.30300   13.10200  1.000 50.74593  ? 1547 LYS A C     1 
ATOM   752  O  O     . LYS A 1 131 ? 18.27700 1.33700   12.88500  1.000 53.26657  ? 1547 LYS A O     1 
ATOM   753  C  CB    . LYS A 1 131 ? 16.71500 -0.83800  13.64300  1.000 51.83922  ? 1547 LYS A CB    1 
ATOM   754  C  CG    . LYS A 1 131 ? 15.88800 -2.09900  13.38200  1.000 60.21904  ? 1547 LYS A CG    1 
ATOM   755  C  CD    . LYS A 1 131 ? 14.97900 -2.43500  14.54800  1.000 68.26494  ? 1547 LYS A CD    1 
ATOM   756  C  CE    . LYS A 1 131 ? 13.87900 -1.39600  14.71100  1.000 71.52936  ? 1547 LYS A CE    1 
ATOM   757  N  NZ    . LYS A 1 131 ? 12.94900 -1.66500  15.85900  1.000 72.15572  ? 1547 LYS A NZ    1 
ATOM   758  N  N     . GLN A 1 132 ? 20.24500 0.26300   13.12200  1.000 49.67318  ? 1548 GLN A N     1 
ATOM   759  C  CA    . GLN A 1 132 ? 21.08800 1.44100   12.92500  1.000 45.45308  ? 1548 GLN A CA    1 
ATOM   760  C  C     . GLN A 1 132 ? 21.30000 1.67200   11.42500  1.000 49.54433  ? 1548 GLN A C     1 
ATOM   761  O  O     . GLN A 1 132 ? 22.40400 1.56600   10.89400  1.000 49.53901  ? 1548 GLN A O     1 
ATOM   762  C  CB    . GLN A 1 132 ? 22.40500 1.26400   13.67600  1.000 47.64302  ? 1548 GLN A CB    1 
ATOM   763  C  CG    . GLN A 1 132 ? 22.22300 1.20300   15.22200  1.000 46.93256  ? 1548 GLN A CG    1 
ATOM   764  C  CD    . GLN A 1 132 ? 23.52900 1.01700   16.00200  1.000 48.42164  ? 1548 GLN A CD    1 
ATOM   765  O  OE1   . GLN A 1 132 ? 24.39800 0.22800   15.61400  1.000 49.10538  ? 1548 GLN A OE1   1 
ATOM   766  N  NE2   . GLN A 1 132 ? 23.66700 1.74300   17.11700  1.000 48.37862  ? 1548 GLN A NE2   1 
ATOM   767  N  N     . HIS A 1 133 ? 20.20000 2.01500   10.74800  1.000 48.68914  ? 1549 HIS A N     1 
ATOM   768  C  CA    . HIS A 1 133 ? 20.12100 2.16100   9.29800   1.000 57.20078  ? 1549 HIS A CA    1 
ATOM   769  C  C     . HIS A 1 133 ? 20.79500 3.43900   8.82400   1.000 54.32445  ? 1549 HIS A C     1 
ATOM   770  O  O     . HIS A 1 133 ? 21.03400 4.37600   9.58600   1.000 48.43094  ? 1549 HIS A O     1 
ATOM   771  C  CB    . HIS A 1 133 ? 18.66800 2.19700   8.82000   1.000 55.81608  ? 1549 HIS A CB    1 
ATOM   772  C  CG    . HIS A 1 133 ? 17.80800 1.11500   9.39100   1.000 65.82254  ? 1549 HIS A CG    1 
ATOM   773  N  ND1   . HIS A 1 133 ? 16.46600 1.29400   9.65000   1.000 71.09686  ? 1549 HIS A ND1   1 
ATOM   774  C  CD2   . HIS A 1 133 ? 18.09500 -0.15800  9.75500   1.000 62.23790  ? 1549 HIS A CD2   1 
ATOM   775  C  CE1   . HIS A 1 133 ? 15.96400 0.17600   10.14700  1.000 66.10244  ? 1549 HIS A CE1   1 
ATOM   776  N  NE2   . HIS A 1 133 ? 16.93200 -0.71800  10.22400  1.000 62.43530  ? 1549 HIS A NE2   1 
ATOM   777  N  N     . ALA A 1 134 ? 21.05000 3.49700   7.52300   1.000 52.83620  ? 1550 ALA A N     1 
ATOM   778  C  CA    . ALA A 1 134 ? 21.44300 4.76600   6.94300   1.000 50.41422  ? 1550 ALA A CA    1 
ATOM   779  C  C     . ALA A 1 134 ? 20.22000 5.66100   6.77200   1.000 49.75390  ? 1550 ALA A C     1 
ATOM   780  O  O     . ALA A 1 134 ? 19.07900 5.19600   6.72900   1.000 49.11791  ? 1550 ALA A O     1 
ATOM   781  C  CB    . ALA A 1 134 ? 22.14000 4.55200   5.59800   1.000 52.85391  ? 1550 ALA A CB    1 
ATOM   782  N  N     . ASP A 1 135 ? 20.46700 6.96500   6.67200   1.000 55.52586  ? 1551 ASP A N     1 
ATOM   783  C  CA    . ASP A 1 135 ? 19.40900 7.92000   6.36500   1.000 61.44179  ? 1551 ASP A CA    1 
ATOM   784  C  C     . ASP A 1 135 ? 19.14600 7.90000   4.85700   1.000 61.42465  ? 1551 ASP A C     1 
ATOM   785  O  O     . ASP A 1 135 ? 19.97000 8.36800   4.06200   1.000 57.87422  ? 1551 ASP A O     1 
ATOM   786  C  CB    . ASP A 1 135 ? 19.79600 9.31600   6.84300   1.000 65.10624  ? 1551 ASP A CB    1 
ATOM   787  C  CG    . ASP A 1 135 ? 18.66000 10.31400  6.70200   1.000 83.34833  ? 1551 ASP A CG    1 
ATOM   788  O  OD1   . ASP A 1 135 ? 17.49400 9.86900   6.66600   1.000 93.75484  ? 1551 ASP A OD1   1 
ATOM   789  O  OD2   . ASP A 1 135 ? 18.92100 11.53600  6.63300   1.000 90.78080  ? 1551 ASP A OD2   1 
ATOM   790  N  N     . VAL A 1 136 ? 17.98700 7.36700   4.46500   1.000 57.42362  ? 1552 VAL A N     1 
ATOM   791  C  CA    . VAL A 1 136 ? 17.61600 7.16600   3.06900   1.000 60.79654  ? 1552 VAL A CA    1 
ATOM   792  C  C     . VAL A 1 136 ? 16.16500 7.57700   2.87600   1.000 58.69890  ? 1552 VAL A C     1 
ATOM   793  O  O     . VAL A 1 136 ? 15.38000 7.64700   3.82300   1.000 70.82051  ? 1552 VAL A O     1 
ATOM   794  C  CB    . VAL A 1 136 ? 17.79700 5.70500   2.63100   1.000 54.74443  ? 1552 VAL A CB    1 
ATOM   795  C  CG1   . VAL A 1 136 ? 19.23200 5.28800   2.80000   1.000 54.35030  ? 1552 VAL A CG1   1 
ATOM   796  C  CG2   . VAL A 1 136 ? 16.88700 4.81300   3.43900   1.000 54.05146  ? 1552 VAL A CG2   1 
ATOM   797  N  N     . GLU A 1 137 ? 15.81800 7.86300   1.63300   1.000 53.91168  ? 1553 GLU A N     1 
ATOM   798  C  CA    . GLU A 1 137 ? 14.45900 8.21100   1.25800   1.000 59.36130  ? 1553 GLU A CA    1 
ATOM   799  C  C     . GLU A 1 137 ? 14.02200 7.34100   0.08400   1.000 52.72098  ? 1553 GLU A C     1 
ATOM   800  O  O     . GLU A 1 137 ? 14.84900 6.83100   -0.67500  1.000 48.92211  ? 1553 GLU A O     1 
ATOM   801  C  CB    . GLU A 1 137 ? 14.33700 9.70900   0.90500   1.000 66.29547  ? 1553 GLU A CB    1 
ATOM   802  C  CG    . GLU A 1 137 ? 15.02000 10.63900  1.92900   1.000 72.92866  ? 1553 GLU A CG    1 
ATOM   803  C  CD    . GLU A 1 137 ? 14.84800 12.12500  1.62100   1.000 76.82650  ? 1553 GLU A CD    1 
ATOM   804  O  OE1   . GLU A 1 137 ? 14.85900 12.49200  0.42900   1.000 83.00092  ? 1553 GLU A OE1   1 
ATOM   805  O  OE2   . GLU A 1 137 ? 14.70000 12.92600  2.57400   1.000 84.46734  ? 1553 GLU A OE2   1 
ATOM   806  N  N     . VAL A 1 138 ? 12.72000 7.12700   -0.01500  1.000 52.14814  ? 1554 VAL A N     1 
ATOM   807  C  CA    . VAL A 1 138 ? 12.13100 6.41900   -1.13500  1.000 55.11543  ? 1554 VAL A CA    1 
ATOM   808  C  C     . VAL A 1 138 ? 11.70900 7.46300   -2.16400  1.000 57.33978  ? 1554 VAL A C     1 
ATOM   809  O  O     . VAL A 1 138 ? 11.01800 8.43400   -1.82600  1.000 62.90805  ? 1554 VAL A O     1 
ATOM   810  C  CB    . VAL A 1 138 ? 10.94400 5.56200   -0.67400  1.000 48.43438  ? 1554 VAL A CB    1 
ATOM   811  C  CG1   . VAL A 1 138 ? 10.41000 4.73000   -1.84300  1.000 53.29713  ? 1554 VAL A CG1   1 
ATOM   812  C  CG2   . VAL A 1 138 ? 11.38700 4.63900   0.46100   1.000 50.53794  ? 1554 VAL A CG2   1 
ATOM   813  N  N     . ILE A 1 139 ? 12.16000 7.30200   -3.40900  1.000 53.79572  ? 1555 ILE A N     1 
ATOM   814  C  CA    . ILE A 1 139 ? 11.86200 8.28900   -4.44700  1.000 54.94498  ? 1555 ILE A CA    1 
ATOM   815  C  C     . ILE A 1 139 ? 11.29500 7.58900   -5.66400  1.000 56.35526  ? 1555 ILE A C     1 
ATOM   816  O  O     . ILE A 1 139 ? 11.49300 6.39100   -5.86600  1.000 52.63778  ? 1555 ILE A O     1 
ATOM   817  C  CB    . ILE A 1 139 ? 13.09100 9.12500   -4.85200  1.000 59.48444  ? 1555 ILE A CB    1 
ATOM   818  C  CG1   . ILE A 1 139 ? 14.36700 8.27200   -4.91800  1.000 59.42178  ? 1555 ILE A CG1   1 
ATOM   819  C  CG2   . ILE A 1 139 ? 13.28500 10.23600  -3.83600  1.000 64.54705  ? 1555 ILE A CG2   1 
ATOM   820  C  CD1   . ILE A 1 139 ? 14.44000 7.25000   -5.98400  1.000 60.90617  ? 1555 ILE A CD1   1 
ATOM   821  N  N     . LEU A 1 140 ? 10.59300 8.36200   -6.48200  1.000 56.47693  ? 1556 LEU A N     1 
ATOM   822  C  CA    . LEU A 1 140 ? 10.03800 7.87100   -7.73400  1.000 53.75004  ? 1556 LEU A CA    1 
ATOM   823  C  C     . LEU A 1 140 ? 11.04300 8.09700   -8.85900  1.000 51.15360  ? 1556 LEU A C     1 
ATOM   824  O  O     . LEU A 1 140 ? 11.44800 9.23700   -9.11300  1.000 49.70025  ? 1556 LEU A O     1 
ATOM   825  C  CB    . LEU A 1 140 ? 8.71800  8.57400   -8.05300  1.000 55.46341  ? 1556 LEU A CB    1 
ATOM   826  C  CG    . LEU A 1 140 ? 8.02800  8.15400   -9.35800  1.000 54.49766  ? 1556 LEU A CG    1 
ATOM   827  C  CD1   . LEU A 1 140 ? 7.62000  6.70100   -9.32200  1.000 55.45769  ? 1556 LEU A CD1   1 
ATOM   828  C  CD2   . LEU A 1 140 ? 6.81000  9.01700   -9.54700  1.000 59.39143  ? 1556 LEU A CD2   1 
ATOM   829  N  N     . THR A 1 141 ? 11.43200 7.02000   -9.53100  1.000 49.98465  ? 1557 THR A N     1 
ATOM   830  C  CA    . THR A 1 141 ? 12.36400 7.08500   -10.64500 1.000 47.55625  ? 1557 THR A CA    1 
ATOM   831  C  C     . THR A 1 141 ? 11.60900 7.17400   -11.97700 1.000 48.34676  ? 1557 THR A C     1 
ATOM   832  O  O     . THR A 1 141 ? 10.40100 6.95200   -12.05300 1.000 49.34162  ? 1557 THR A O     1 
ATOM   833  C  CB    . THR A 1 141 ? 13.28600 5.86300   -10.65600 1.000 47.74896  ? 1557 THR A CB    1 
ATOM   834  O  OG1   . THR A 1 141 ? 12.61900 4.78500   -11.33400 1.000 45.58767  ? 1557 THR A OG1   1 
ATOM   835  C  CG2   . THR A 1 141 ? 13.64500 5.42800   -9.22200  1.000 49.16670  ? 1557 THR A CG2   1 
ATOM   836  N  N     . GLU A 1 142 ? 12.35200 7.47100   -13.04500 1.000 45.75767  ? 1558 GLU A N     1 
ATOM   837  C  CA    . GLU A 1 142 ? 11.72700 7.70900   -14.34900 1.000 56.58209  ? 1558 GLU A CA    1 
ATOM   838  C  C     . GLU A 1 142 ? 11.06700 6.45200   -14.92000 1.000 50.72863  ? 1558 GLU A C     1 
ATOM   839  O  O     . GLU A 1 142 ? 9.96300  6.52200   -15.48000 1.000 47.13830  ? 1558 GLU A O     1 
ATOM   840  C  CB    . GLU A 1 142 ? 12.77100 8.23800   -15.32900 1.000 60.56250  ? 1558 GLU A CB    1 
ATOM   841  C  CG    . GLU A 1 142 ? 13.40500 9.56500   -14.93500 1.000 72.34175  ? 1558 GLU A CG    1 
ATOM   842  C  CD    . GLU A 1 142 ? 13.95400 10.32800  -16.13300 1.000 88.83816  ? 1558 GLU A CD    1 
ATOM   843  O  OE1   . GLU A 1 142 ? 14.26700 9.68600   -17.16300 1.000 100.97676 ? 1558 GLU A OE1   1 
ATOM   844  O  OE2   . GLU A 1 142 ? 14.07000 11.57200  -16.04300 1.000 90.49353  ? 1558 GLU A OE2   1 
ATOM   845  N  N     . LYS A 1 143 ? 11.73800 5.29900   -14.83000 1.000 49.80966  ? 1559 LYS A N     1 
ATOM   846  C  CA    . LYS A 1 143 ? 11.28100 4.12500   -15.56600 1.000 47.98326  ? 1559 LYS A CA    1 
ATOM   847  C  C     . LYS A 1 143 ? 11.28200 2.83200   -14.76300 1.000 46.99397  ? 1559 LYS A C     1 
ATOM   848  O  O     . LYS A 1 143 ? 10.85300 1.80600   -15.30000 1.000 45.41177  ? 1559 LYS A O     1 
ATOM   849  C  CB    . LYS A 1 143 ? 12.13600 3.89200   -16.83500 1.000 46.66283  ? 1559 LYS A CB    1 
ATOM   850  C  CG    . LYS A 1 143 ? 12.55700 5.09000   -17.60100 1.000 54.02593  ? 1559 LYS A CG    1 
ATOM   851  C  CD    . LYS A 1 143 ? 13.34200 4.67000   -18.86000 1.000 51.89347  ? 1559 LYS A CD    1 
ATOM   852  C  CE    . LYS A 1 143 ? 13.85400 5.86900   -19.61100 1.000 64.15438  ? 1559 LYS A CE    1 
ATOM   853  N  NZ    . LYS A 1 143 ? 14.37400 5.50900   -20.96500 1.000 73.82877  ? 1559 LYS A NZ    1 
ATOM   854  N  N     . LYS A 1 144 ? 11.76300 2.83000   -13.51800 1.000 50.48386  ? 1560 LYS A N     1 
ATOM   855  C  CA    . LYS A 1 144 ? 11.94100 1.59600   -12.76700 1.000 44.49681  ? 1560 LYS A CA    1 
ATOM   856  C  C     . LYS A 1 144 ? 10.95500 1.46000   -11.61500 1.000 50.02883  ? 1560 LYS A C     1 
ATOM   857  O  O     . LYS A 1 144 ? 11.02900 0.48500   -10.85900 1.000 48.32511  ? 1560 LYS A O     1 
ATOM   858  C  CB    . LYS A 1 144 ? 13.38100 1.51100   -12.25800 1.000 47.21311  ? 1560 LYS A CB    1 
ATOM   859  C  CG    . LYS A 1 144 ? 14.39500 1.73100   -13.36900 1.000 45.90550  ? 1560 LYS A CG    1 
ATOM   860  C  CD    . LYS A 1 144 ? 15.80900 1.95300   -12.84800 1.000 43.84186  ? 1560 LYS A CD    1 
ATOM   861  C  CE    . LYS A 1 144 ? 15.85200 3.07600   -11.80800 1.000 44.45419  ? 1560 LYS A CE    1 
ATOM   862  N  NZ    . LYS A 1 144 ? 17.24400 3.43900   -11.38200 1.000 43.31991  ? 1560 LYS A NZ    1 
ATOM   863  N  N     . GLY A 1 145 ? 10.00300 2.37800   -11.50000 1.000 46.28758  ? 1561 GLY A N     1 
ATOM   864  C  CA    . GLY A 1 145 ? 9.14600  2.43300   -10.33800 1.000 50.76014  ? 1561 GLY A CA    1 
ATOM   865  C  C     . GLY A 1 145 ? 9.79000  3.26500   -9.24400  1.000 49.80335  ? 1561 GLY A C     1 
ATOM   866  O  O     . GLY A 1 145 ? 10.50900 4.22600   -9.53100  1.000 47.75212  ? 1561 GLY A O     1 
ATOM   867  N  N     . TRP A 1 146 ? 9.55400  2.90900   -7.98700  1.000 46.54680  ? 1562 TRP A N     1 
ATOM   868  C  CA    . TRP A 1 146 ? 10.14400 3.65200   -6.88600  1.000 50.38139  ? 1562 TRP A CA    1 
ATOM   869  C  C     . TRP A 1 146 ? 11.54900 3.13100   -6.59900  1.000 48.95001  ? 1562 TRP A C     1 
ATOM   870  O  O     . TRP A 1 146 ? 11.91600 2.01800   -6.99300  1.000 52.53148  ? 1562 TRP A O     1 
ATOM   871  C  CB    . TRP A 1 146 ? 9.27500  3.54200   -5.64400  1.000 50.04239  ? 1562 TRP A CB    1 
ATOM   872  C  CG    . TRP A 1 146 ? 7.92900  4.15400   -5.79600  1.000 53.63357  ? 1562 TRP A CG    1 
ATOM   873  C  CD1   . TRP A 1 146 ? 6.84000  3.59300   -6.37900  1.000 53.65359  ? 1562 TRP A CD1   1 
ATOM   874  C  CD2   . TRP A 1 146 ? 7.50900  5.44900   -5.31100  1.000 54.35251  ? 1562 TRP A CD2   1 
ATOM   875  N  NE1   . TRP A 1 146 ? 5.76800  4.45600   -6.30400  1.000 52.65266  ? 1562 TRP A NE1   1 
ATOM   876  C  CE2   . TRP A 1 146 ? 6.15300  5.59900   -5.65000  1.000 53.37803  ? 1562 TRP A CE2   1 
ATOM   877  C  CE3   . TRP A 1 146 ? 8.15500  6.49100   -4.63200  1.000 61.41707  ? 1562 TRP A CE3   1 
ATOM   878  C  CZ2   . TRP A 1 146 ? 5.42700  6.74600   -5.33700  1.000 57.07895  ? 1562 TRP A CZ2   1 
ATOM   879  C  CZ3   . TRP A 1 146 ? 7.42900  7.64300   -4.32300  1.000 59.21086  ? 1562 TRP A CZ3   1 
ATOM   880  C  CH2   . TRP A 1 146 ? 6.08300  7.75800   -4.67700  1.000 56.94179  ? 1562 TRP A CH2   1 
ATOM   881  N  N     . GLY A 1 147 ? 12.33800 3.95300   -5.90100  1.000 45.26018  ? 1563 GLY A N     1 
ATOM   882  C  CA    . GLY A 1 147 ? 13.72500 3.63800   -5.63500  1.000 45.71481  ? 1563 GLY A CA    1 
ATOM   883  C  C     . GLY A 1 147 ? 14.14000 4.15600   -4.27000  1.000 48.87008  ? 1563 GLY A C     1 
ATOM   884  O  O     . GLY A 1 147 ? 13.32800 4.70200   -3.52400  1.000 49.80029  ? 1563 GLY A O     1 
ATOM   885  N  N     . LEU A 1 148 ? 15.42100 3.97500   -3.96000  1.000 47.25267  ? 1564 LEU A N     1 
ATOM   886  C  CA    . LEU A 1 148 ? 16.01300 4.41100   -2.70500  1.000 49.56432  ? 1564 LEU A CA    1 
ATOM   887  C  C     . LEU A 1 148 ? 17.15500 5.35800   -3.00900  1.000 51.80808  ? 1564 LEU A C     1 
ATOM   888  O  O     . LEU A 1 148 ? 17.96600 5.08100   -3.90000  1.000 49.35733  ? 1564 LEU A O     1 
ATOM   889  C  CB    . LEU A 1 148 ? 16.55400 3.22700   -1.91800  1.000 49.50048  ? 1564 LEU A CB    1 
ATOM   890  C  CG    . LEU A 1 148 ? 15.64400 2.55000   -0.92300  1.000 53.81058  ? 1564 LEU A CG    1 
ATOM   891  C  CD1   . LEU A 1 148 ? 16.53400 1.73300   -0.00600  1.000 65.86729  ? 1564 LEU A CD1   1 
ATOM   892  C  CD2   . LEU A 1 148 ? 14.84900 3.56600   -0.14600  1.000 50.57653  ? 1564 LEU A CD2   1 
ATOM   893  N  N     . ARG A 1 149 ? 17.22600 6.46900   -2.28200  1.000 51.54536  ? 1565 ARG A N     1 
ATOM   894  C  CA    . ARG A 1 149 ? 18.32800 7.40000   -2.45000  1.000 55.68175  ? 1565 ARG A CA    1 
ATOM   895  C  C     . ARG A 1 149 ? 18.90600 7.75300   -1.08700  1.000 54.56376  ? 1565 ARG A C     1 
ATOM   896  O  O     . ARG A 1 149 ? 18.22100 7.67100   -0.07600  1.000 49.42845  ? 1565 ARG A O     1 
ATOM   897  C  CB    . ARG A 1 149 ? 17.89900 8.67200   -3.19600  1.000 56.19444  ? 1565 ARG A CB    1 
ATOM   898  C  CG    . ARG A 1 149 ? 17.37000 9.78200   -2.29800  1.000 62.47473  ? 1565 ARG A CG    1 
ATOM   899  C  CD    . ARG A 1 149 ? 17.27000 11.12900  -3.01900  1.000 62.43747  ? 1565 ARG A CD    1 
ATOM   900  N  NE    . ARG A 1 149 ? 16.20800 11.95800  -2.44700  1.000 64.70094  ? 1565 ARG A NE    1 
ATOM   901  C  CZ    . ARG A 1 149 ? 15.49600 12.84800  -3.13500  1.000 67.79731  ? 1565 ARG A CZ    1 
ATOM   902  N  NH1   . ARG A 1 149 ? 15.72700 13.04400  -4.43100  1.000 70.13021  ? 1565 ARG A NH1   1 
ATOM   903  N  NH2   . ARG A 1 149 ? 14.54500 13.54300  -2.53000  1.000 71.19365  ? 1565 ARG A NH2   1 
ATOM   904  N  N     . ALA A 1 150 ? 20.18100 8.12300   -1.07600  1.000 56.35638  ? 1566 ALA A N     1 
ATOM   905  C  CA    . ALA A 1 150 ? 20.85600 8.52600   0.14000   1.000 60.41495  ? 1566 ALA A CA    1 
ATOM   906  C  C     . ALA A 1 150 ? 20.43900 9.94500   0.49800   1.000 61.43026  ? 1566 ALA A C     1 
ATOM   907  O  O     . ALA A 1 150 ? 20.50400 10.84600  -0.34500  1.000 61.94840  ? 1566 ALA A O     1 
ATOM   908  C  CB    . ALA A 1 150 ? 22.36900 8.44200   -0.04600  1.000 59.46643  ? 1566 ALA A CB    1 
ATOM   909  N  N     . ALA A 1 151 ? 19.99600 10.14500  1.74300   1.000 62.14900  ? 1567 ALA A N     1 
ATOM   910  C  CA    . ALA A 1 151 ? 19.61300 11.47900  2.19100   1.000 65.15186  ? 1567 ALA A CA    1 
ATOM   911  C  C     . ALA A 1 151 ? 20.78200 12.25900  2.77600   1.000 67.85637  ? 1567 ALA A C     1 
ATOM   912  O  O     . ALA A 1 151 ? 20.61800 13.42800  3.13300   1.000 69.33787  ? 1567 ALA A O     1 
ATOM   913  C  CB    . ALA A 1 151 ? 18.48000 11.38700  3.21300   1.000 63.41150  ? 1567 ALA A CB    1 
ATOM   914  N  N     . LYS A 1 152 ? 21.95300 11.63900  2.86800   1.000 64.90307  ? 1568 LYS A N     1 
ATOM   915  C  CA    . LYS A 1 152 ? 23.16700 12.26400  3.37400   1.000 71.20248  ? 1568 LYS A CA    1 
ATOM   916  C  C     . LYS A 1 152 ? 24.30600 11.41900  2.82900   1.000 70.59161  ? 1568 LYS A C     1 
ATOM   917  O  O     . LYS A 1 152 ? 24.09600 10.28000  2.41800   1.000 71.48133  ? 1568 LYS A O     1 
ATOM   918  C  CB    . LYS A 1 152 ? 23.16900 12.33700  4.91900   1.000 73.53733  ? 1568 LYS A CB    1 
ATOM   919  C  CG    . LYS A 1 152 ? 24.52400 12.63600  5.60300   1.000 79.82760  ? 1568 LYS A CG    1 
ATOM   920  C  CD    . LYS A 1 152 ? 24.74200 14.13800  5.87000   1.000 88.87651  ? 1568 LYS A CD    1 
ATOM   921  C  CE    . LYS A 1 152 ? 26.17900 14.59800  5.57500   1.000 89.29115  ? 1568 LYS A CE    1 
ATOM   922  N  NZ    . LYS A 1 152 ? 26.34500 15.14300  4.18300   1.000 88.60686  ? 1568 LYS A NZ    1 
ATOM   923  N  N     . ASP A 1 153 ? 25.50100 11.98800  2.79200   1.000 70.06262  ? 1569 ASP A N     1 
ATOM   924  C  CA    . ASP A 1 153 ? 26.63600 11.23200  2.28700   1.000 72.77677  ? 1569 ASP A CA    1 
ATOM   925  C  C     . ASP A 1 153 ? 26.84000 9.97700   3.12500   1.000 70.06886  ? 1569 ASP A C     1 
ATOM   926  O  O     . ASP A 1 153 ? 26.87400 10.03300  4.35500   1.000 75.72373  ? 1569 ASP A O     1 
ATOM   927  C  CB    . ASP A 1 153 ? 27.89500 12.09800  2.29400   1.000 77.96910  ? 1569 ASP A CB    1 
ATOM   928  C  CG    . ASP A 1 153 ? 27.76800 13.32900  1.40200   1.000 80.92387  ? 1569 ASP A CG    1 
ATOM   929  O  OD1   . ASP A 1 153 ? 26.73900 13.47000  0.70100   1.000 81.67708  ? 1569 ASP A OD1   1 
ATOM   930  O  OD2   . ASP A 1 153 ? 28.70700 14.15100  1.40400   1.000 82.60098  ? 1569 ASP A OD2   1 
ATOM   931  N  N     . LEU A 1 154 ? 26.94300 8.83400   2.45800   1.000 68.06915  ? 1570 LEU A N     1 
ATOM   932  C  CA    . LEU A 1 154 ? 27.22200 7.58400   3.14700   1.000 66.46967  ? 1570 LEU A CA    1 
ATOM   933  C  C     . LEU A 1 154 ? 28.64300 7.15500   2.83000   1.000 68.84801  ? 1570 LEU A C     1 
ATOM   934  O  O     . LEU A 1 154 ? 28.94300 6.87800   1.65900   1.000 67.81127  ? 1570 LEU A O     1 
ATOM   935  C  CB    . LEU A 1 154 ? 26.23700 6.50000   2.72600   1.000 67.22112  ? 1570 LEU A CB    1 
ATOM   936  C  CG    . LEU A 1 154 ? 24.74800 6.83700   2.75300   1.000 63.49401  ? 1570 LEU A CG    1 
ATOM   937  C  CD1   . LEU A 1 154 ? 23.95000 5.58600   2.47800   1.000 60.14708  ? 1570 LEU A CD1   1 
ATOM   938  C  CD2   . LEU A 1 154 ? 24.35500 7.43500   4.08300   1.000 61.09040  ? 1570 LEU A CD2   1 
ATOM   939  N  N     . PRO A 1 155 ? 29.54500 7.08700   3.80700   1.000 69.78560  ? 1571 PRO A N     1 
ATOM   940  C  CA    . PRO A 1 155 ? 30.88700 6.55700   3.53700   1.000 67.72065  ? 1571 PRO A CA    1 
ATOM   941  C  C     . PRO A 1 155 ? 30.80400 5.14200   2.98500   1.000 69.85686  ? 1571 PRO A C     1 
ATOM   942  O  O     . PRO A 1 155 ? 29.76100 4.48400   3.02000   1.000 69.41553  ? 1571 PRO A O     1 
ATOM   943  C  CB    . PRO A 1 155 ? 31.57600 6.58200   4.90800   1.000 68.35180  ? 1571 PRO A CB    1 
ATOM   944  C  CG    . PRO A 1 155 ? 30.71900 7.46100   5.76600   1.000 65.55093  ? 1571 PRO A CG    1 
ATOM   945  C  CD    . PRO A 1 155 ? 29.33200 7.36800   5.23700   1.000 67.37320  ? 1571 PRO A CD    1 
ATOM   946  N  N     . SER A 1 156 ? 31.92900 4.67100   2.46200   1.000 69.39562  ? 1572 SER A N     1 
ATOM   947  C  CA    . SER A 1 156 ? 31.98700 3.32500   1.91300   1.000 72.17857  ? 1572 SER A CA    1 
ATOM   948  C  C     . SER A 1 156 ? 31.90600 2.29200   3.03200   1.000 75.41580  ? 1572 SER A C     1 
ATOM   949  O  O     . SER A 1 156 ? 32.40100 2.50400   4.14200   1.000 74.29461  ? 1572 SER A O     1 
ATOM   950  C  CB    . SER A 1 156 ? 33.27100 3.13700   1.10700   1.000 80.33481  ? 1572 SER A CB    1 
ATOM   951  O  OG    . SER A 1 156 ? 33.66600 1.77800   1.07700   1.000 87.44882  ? 1572 SER A OG    1 
ATOM   952  N  N     . ASN A 1 157 ? 31.26500 1.16500   2.72400   1.000 69.91777  ? 1573 ASN A N     1 
ATOM   953  C  CA    . ASN A 1 157 ? 31.04600 0.08100   3.68200   1.000 68.26300  ? 1573 ASN A CA    1 
ATOM   954  C  C     . ASN A 1 157 ? 30.08700 0.50700   4.79200   1.000 67.36565  ? 1573 ASN A C     1 
ATOM   955  O  O     . ASN A 1 157 ? 30.29300 0.19700   5.96300   1.000 69.13109  ? 1573 ASN A O     1 
ATOM   956  C  CB    . ASN A 1 157 ? 32.36600 -0.43700  4.26500   1.000 71.31748  ? 1573 ASN A CB    1 
ATOM   957  C  CG    . ASN A 1 157 ? 32.24900 -1.85200  4.81000   1.000 74.90671  ? 1573 ASN A CG    1 
ATOM   958  O  OD1   . ASN A 1 157 ? 31.26700 -2.56500  4.54700   1.000 67.46807  ? 1573 ASN A OD1   1 
ATOM   959  N  ND2   . ASN A 1 157 ? 33.25800 -2.27200  5.56600   1.000 78.55566  ? 1573 ASN A ND2   1 
ATOM   960  N  N     . THR A 1 158 ? 29.01900 1.19800   4.41800   1.000 61.66087  ? 1574 THR A N     1 
ATOM   961  C  CA    . THR A 1 158 ? 28.02100 1.66600   5.36500   1.000 59.75076  ? 1574 THR A CA    1 
ATOM   962  C  C     . THR A 1 158 ? 26.78200 0.79000   5.29000   1.000 60.90880  ? 1574 THR A C     1 
ATOM   963  O  O     . THR A 1 158 ? 26.27300 0.52200   4.19400   1.000 55.78213  ? 1574 THR A O     1 
ATOM   964  C  CB    . THR A 1 158 ? 27.64600 3.11500   5.08200   1.000 60.82918  ? 1574 THR A CB    1 
ATOM   965  O  OG1   . THR A 1 158 ? 28.77400 3.94400   5.36400   1.000 65.78431  ? 1574 THR A OG1   1 
ATOM   966  C  CG2   . THR A 1 158 ? 26.45900 3.53400   5.93200   1.000 55.12657  ? 1574 THR A CG2   1 
ATOM   967  N  N     . PHE A 1 159 ? 26.29900 0.35100   6.45500   1.000 53.88477  ? 1575 PHE A N     1 
ATOM   968  C  CA    . PHE A 1 159 ? 25.10300 -0.48000  6.51000   1.000 51.10040  ? 1575 PHE A CA    1 
ATOM   969  C  C     . PHE A 1 159 ? 23.89100 0.34400   6.09100   1.000 54.95312  ? 1575 PHE A C     1 
ATOM   970  O  O     . PHE A 1 159 ? 23.60700 1.38900   6.68200   1.000 51.51512  ? 1575 PHE A O     1 
ATOM   971  C  CB    . PHE A 1 159 ? 24.92300 -1.04300  7.92000   1.000 52.02879  ? 1575 PHE A CB    1 
ATOM   972  C  CG    . PHE A 1 159 ? 23.61700 -1.75500  8.13400   1.000 49.57847  ? 1575 PHE A CG    1 
ATOM   973  C  CD1   . PHE A 1 159 ? 23.21600 -2.77300  7.27700   1.000 47.59745  ? 1575 PHE A CD1   1 
ATOM   974  C  CD2   . PHE A 1 159 ? 22.79700 -1.42400  9.20500   1.000 49.55520  ? 1575 PHE A CD2   1 
ATOM   975  C  CE1   . PHE A 1 159 ? 22.01000 -3.44700  7.47200   1.000 45.02303  ? 1575 PHE A CE1   1 
ATOM   976  C  CE2   . PHE A 1 159 ? 21.58600 -2.08600  9.41600   1.000 47.49990  ? 1575 PHE A CE2   1 
ATOM   977  C  CZ    . PHE A 1 159 ? 21.18800 -3.10100  8.54300   1.000 50.26196  ? 1575 PHE A CZ    1 
ATOM   978  N  N     . VAL A 1 160 ? 23.17500 -0.11000  5.06900   1.000 50.45421  ? 1576 VAL A N     1 
ATOM   979  C  CA    . VAL A 1 160 ? 22.05700 0.67500   4.55800   1.000 50.63684  ? 1576 VAL A CA    1 
ATOM   980  C  C     . VAL A 1 160 ? 20.78300 0.22700   5.25800   1.000 50.79329  ? 1576 VAL A C     1 
ATOM   981  O  O     . VAL A 1 160 ? 20.19500 0.97400   6.04800   1.000 53.80835  ? 1576 VAL A O     1 
ATOM   982  C  CB    . VAL A 1 160 ? 21.90600 0.55700   3.02400   1.000 52.05840  ? 1576 VAL A CB    1 
ATOM   983  C  CG1   . VAL A 1 160 ? 20.66200 1.29500   2.56000   1.000 49.15776  ? 1576 VAL A CG1   1 
ATOM   984  C  CG2   . VAL A 1 160 ? 23.12800 1.10200   2.30300   1.000 51.30538  ? 1576 VAL A CG2   1 
ATOM   985  N  N     . LEU A 1 161 ? 20.33500 -0.98100  4.93600   1.000 53.27367  ? 1577 LEU A N     1 
ATOM   986  C  CA    . LEU A 1 161 ? 19.10400 -1.55600  5.45600   1.000 52.27355  ? 1577 LEU A CA    1 
ATOM   987  C  C     . LEU A 1 161 ? 19.20400 -3.06300  5.32600   1.000 49.58583  ? 1577 LEU A C     1 
ATOM   988  O  O     . LEU A 1 161 ? 19.93000 -3.57900  4.46700   1.000 49.22739  ? 1577 LEU A O     1 
ATOM   989  C  CB    . LEU A 1 161 ? 17.85400 -1.06800  4.70300   1.000 49.14369  ? 1577 LEU A CB    1 
ATOM   990  C  CG    . LEU A 1 161 ? 17.37700 0.37300   4.88200   1.000 58.01147  ? 1577 LEU A CG    1 
ATOM   991  C  CD1   . LEU A 1 161 ? 16.67000 0.85000   3.62900   1.000 50.93363  ? 1577 LEU A CD1   1 
ATOM   992  C  CD2   . LEU A 1 161 ? 16.49000 0.52700   6.12100   1.000 55.09501  ? 1577 LEU A CD2   1 
ATOM   993  N  N     . GLU A 1 162 ? 18.44000 -3.75800  6.16800   1.000 45.82009  ? 1578 GLU A N     1 
ATOM   994  C  CA    . GLU A 1 162 ? 18.26400 -5.19700  6.03300   1.000 49.93136  ? 1578 GLU A CA    1 
ATOM   995  C  C     . GLU A 1 162 ? 17.17500 -5.49600  5.00900   1.000 45.48507  ? 1578 GLU A C     1 
ATOM   996  O  O     . GLU A 1 162 ? 16.13600 -4.82800  4.97400   1.000 44.17784  ? 1578 GLU A O     1 
ATOM   997  C  CB    . GLU A 1 162 ? 17.89300 -5.83200  7.37600   1.000 44.10056  ? 1578 GLU A CB    1 
ATOM   998  C  CG    . GLU A 1 162 ? 17.41400 -7.28200  7.23200   1.000 52.01036  ? 1578 GLU A CG    1 
ATOM   999  C  CD    . GLU A 1 162 ? 17.22200 -8.00500  8.56400   1.000 54.63173  ? 1578 GLU A CD    1 
ATOM   1000 O  OE1   . GLU A 1 162 ? 17.36300 -7.36600  9.62600   1.000 47.03586  ? 1578 GLU A OE1   1 
ATOM   1001 O  OE2   . GLU A 1 162 ? 16.92800 -9.22200  8.54800   1.000 49.89628  ? 1578 GLU A OE2   1 
ATOM   1002 N  N     . TYR A 1 163 ? 17.41700 -6.49700  4.16500   1.000 45.71532  ? 1579 TYR A N     1 
ATOM   1003 C  CA    . TYR A 1 163 ? 16.37900 -6.99800  3.26800   1.000 46.39444  ? 1579 TYR A CA    1 
ATOM   1004 C  C     . TYR A 1 163 ? 15.49600 -7.96900  4.04500   1.000 46.95011  ? 1579 TYR A C     1 
ATOM   1005 O  O     . TYR A 1 163 ? 15.82100 -9.14200  4.16800   1.000 45.66044  ? 1579 TYR A O     1 
ATOM   1006 C  CB    . TYR A 1 163 ? 16.98700 -7.68100  2.04400   1.000 44.79132  ? 1579 TYR A CB    1 
ATOM   1007 C  CG    . TYR A 1 163 ? 15.98700 -7.84100  0.91600   1.000 40.92468  ? 1579 TYR A CG    1 
ATOM   1008 C  CD1   . TYR A 1 163 ? 15.67700 -6.76400  0.07000   1.000 39.49153  ? 1579 TYR A CD1   1 
ATOM   1009 C  CD2   . TYR A 1 163 ? 15.34200 -9.06000  0.69800   1.000 43.38464  ? 1579 TYR A CD2   1 
ATOM   1010 C  CE1   . TYR A 1 163 ? 14.75000 -6.90700  -0.94900  1.000 39.25872  ? 1579 TYR A CE1   1 
ATOM   1011 C  CE2   . TYR A 1 163 ? 14.42000 -9.21500  -0.31800  1.000 43.54475  ? 1579 TYR A CE2   1 
ATOM   1012 C  CZ    . TYR A 1 163 ? 14.13200 -8.13200  -1.14200  1.000 41.16246  ? 1579 TYR A CZ    1 
ATOM   1013 O  OH    . TYR A 1 163 ? 13.20600 -8.28200  -2.13500  1.000 41.30690  ? 1579 TYR A OH    1 
ATOM   1014 N  N     . CYS A 1 164 ? 14.36500 -7.49100  4.54900   1.000 44.76309  ? 1580 CYS A N     1 
ATOM   1015 C  CA    . CYS A 1 164 ? 13.41200 -8.31300  5.27700   1.000 45.53083  ? 1580 CYS A CA    1 
ATOM   1016 C  C     . CYS A 1 164 ? 12.31800 -8.80800  4.34600   1.000 47.40455  ? 1580 CYS A C     1 
ATOM   1017 O  O     . CYS A 1 164 ? 11.98300 -8.15400  3.35800   1.000 46.51111  ? 1580 CYS A O     1 
ATOM   1018 C  CB    . CYS A 1 164 ? 12.75500 -7.52700  6.41200   1.000 49.18042  ? 1580 CYS A CB    1 
ATOM   1019 S  SG    . CYS A 1 164 ? 13.85100 -7.04400  7.75200   1.000 52.50635  ? 1580 CYS A SG    1 
ATOM   1020 N  N     . GLY A 1 165 ? 11.72300 -9.93500  4.70600   1.000 46.23599  ? 1581 GLY A N     1 
ATOM   1021 C  CA    . GLY A 1 165 ? 10.57500 -10.43600 3.98100   1.000 47.67030  ? 1581 GLY A CA    1 
ATOM   1022 C  C     . GLY A 1 165 ? 10.04400 -11.69200 4.64000   1.000 50.96287  ? 1581 GLY A C     1 
ATOM   1023 O  O     . GLY A 1 165 ? 10.37900 -11.99600 5.78200   1.000 51.72808  ? 1581 GLY A O     1 
ATOM   1024 N  N     . GLU A 1 166 ? 9.20700  -12.42800 3.91000   1.000 50.37507  ? 1582 GLU A N     1 
ATOM   1025 C  CA    . GLU A 1 166 ? 8.75000  -13.74000 4.35400   1.000 51.86318  ? 1582 GLU A CA    1 
ATOM   1026 C  C     . GLU A 1 166 ? 9.70800  -14.79700 3.82700   1.000 57.30108  ? 1582 GLU A C     1 
ATOM   1027 O  O     . GLU A 1 166 ? 10.07500 -14.77000 2.64800   1.000 54.73548  ? 1582 GLU A O     1 
ATOM   1028 C  CB    . GLU A 1 166 ? 7.33100  -14.02300 3.86900   1.000 57.12555  ? 1582 GLU A CB    1 
ATOM   1029 C  CG    . GLU A 1 166 ? 6.28000  -13.11500 4.48200   1.000 54.16502  ? 1582 GLU A CG    1 
ATOM   1030 C  CD    . GLU A 1 166 ? 4.94600  -13.23400 3.77400   1.000 59.62344  ? 1582 GLU A CD    1 
ATOM   1031 O  OE1   . GLU A 1 166 ? 4.78700  -12.65000 2.68000   1.000 57.48645  ? 1582 GLU A OE1   1 
ATOM   1032 O  OE2   . GLU A 1 166 ? 4.05400  -13.92000 4.30800   1.000 63.95723  ? 1582 GLU A OE2   1 
ATOM   1033 N  N     . VAL A 1 167 ? 10.14500 -15.69500 4.70300   1.000 53.91652  ? 1583 VAL A N     1 
ATOM   1034 C  CA    . VAL A 1 167 ? 11.06900 -16.75000 4.31800   1.000 57.42188  ? 1583 VAL A CA    1 
ATOM   1035 C  C     . VAL A 1 167 ? 10.24200 -17.93600 3.83600   1.000 54.66430  ? 1583 VAL A C     1 
ATOM   1036 O  O     . VAL A 1 167 ? 9.44000  -18.49200 4.59300   1.000 61.17988  ? 1583 VAL A O     1 
ATOM   1037 C  CB    . VAL A 1 167 ? 11.99000 -17.14000 5.48200   1.000 59.15162  ? 1583 VAL A CB    1 
ATOM   1038 C  CG1   . VAL A 1 167 ? 13.07800 -18.08100 5.00500   1.000 64.60662  ? 1583 VAL A CG1   1 
ATOM   1039 C  CG2   . VAL A 1 167 ? 12.60900 -15.92100 6.08400   1.000 58.81837  ? 1583 VAL A CG2   1 
ATOM   1040 N  N     . LEU A 1 168 ? 10.42600 -18.31000 2.57200   1.000 55.83195  ? 1584 LEU A N     1 
ATOM   1041 C  CA    . LEU A 1 168 ? 9.64800  -19.35800 1.93100   1.000 53.77068  ? 1584 LEU A CA    1 
ATOM   1042 C  C     . LEU A 1 168 ? 10.48200 -20.61800 1.76300   1.000 59.20754  ? 1584 LEU A C     1 
ATOM   1043 O  O     . LEU A 1 168 ? 11.68300 -20.54700 1.48000   1.000 60.98403  ? 1584 LEU A O     1 
ATOM   1044 C  CB    . LEU A 1 168 ? 9.15200  -18.91600 0.55000   1.000 59.22248  ? 1584 LEU A CB    1 
ATOM   1045 C  CG    . LEU A 1 168 ? 8.70000  -17.46200 0.44200   1.000 51.34662  ? 1584 LEU A CG    1 
ATOM   1046 C  CD1   . LEU A 1 168 ? 8.37700  -17.13900 -1.01800  1.000 50.35499  ? 1584 LEU A CD1   1 
ATOM   1047 C  CD2   . LEU A 1 168 ? 7.49000  -17.21000 1.33200   1.000 50.54747  ? 1584 LEU A CD2   1 
ATOM   1048 N  N     . ASP A 1 169 ? 9.83500  -21.77200 1.91600   1.000 58.17116  ? 1585 ASP A N     1 
ATOM   1049 C  CA    . ASP A 1 169 ? 10.43700 -23.01300 1.46200   1.000 61.87292  ? 1585 ASP A CA    1 
ATOM   1050 C  C     . ASP A 1 169 ? 10.15100 -23.18800 -0.03200  1.000 60.23170  ? 1585 ASP A C     1 
ATOM   1051 O  O     . ASP A 1 169 ? 9.39600  -22.42000 -0.63700  1.000 59.37790  ? 1585 ASP A O     1 
ATOM   1052 C  CB    . ASP A 1 169 ? 9.94100  -24.20000 2.29300   1.000 60.26911  ? 1585 ASP A CB    1 
ATOM   1053 C  CG    . ASP A 1 169 ? 8.43700  -24.45000 2.16200   1.000 67.58328  ? 1585 ASP A CG    1 
ATOM   1054 O  OD1   . ASP A 1 169 ? 7.78300  -23.91300 1.24000   1.000 62.68269  ? 1585 ASP A OD1   1 
ATOM   1055 O  OD2   . ASP A 1 169 ? 7.90500  -25.22300 2.99300   1.000 69.12031  ? 1585 ASP A OD2   1 
ATOM   1056 N  N     . HIS A 1 170 ? 10.77000 -24.19900 -0.64400  1.000 58.31731  ? 1586 HIS A N     1 
ATOM   1057 C  CA    . HIS A 1 170 ? 10.68500 -24.27100 -2.09900  1.000 63.05920  ? 1586 HIS A CA    1 
ATOM   1058 C  C     . HIS A 1 170 ? 9.25200  -24.45000 -2.57000  1.000 62.87219  ? 1586 HIS A C     1 
ATOM   1059 O  O     . HIS A 1 170 ? 8.90200  -24.00300 -3.66900  1.000 60.85230  ? 1586 HIS A O     1 
ATOM   1060 C  CB    . HIS A 1 170 ? 11.54700 -25.39300 -2.66800  1.000 64.45327  ? 1586 HIS A CB    1 
ATOM   1061 C  CG    . HIS A 1 170 ? 11.62900 -25.35000 -4.16100  1.000 70.17382  ? 1586 HIS A CG    1 
ATOM   1062 N  ND1   . HIS A 1 170 ? 11.22500 -26.39500 -4.96500  1.000 72.79916  ? 1586 HIS A ND1   1 
ATOM   1063 C  CD2   . HIS A 1 170 ? 12.01200 -24.35700 -4.99800  1.000 68.34478  ? 1586 HIS A CD2   1 
ATOM   1064 C  CE1   . HIS A 1 170 ? 11.38500 -26.05900 -6.23300  1.000 69.44529  ? 1586 HIS A CE1   1 
ATOM   1065 N  NE2   . HIS A 1 170 ? 11.86500 -24.82800 -6.27900  1.000 70.78826  ? 1586 HIS A NE2   1 
ATOM   1066 N  N     . LYS A 1 171 ? 8.40200  -25.07900 -1.75700  1.000 62.41950  ? 1587 LYS A N     1 
ATOM   1067 C  CA    . LYS A 1 171 ? 7.03300  -25.30500 -2.19700  1.000 63.90095  ? 1587 LYS A CA    1 
ATOM   1068 C  C     . LYS A 1 171 ? 6.15800  -24.05500 -2.03700  1.000 63.71703  ? 1587 LYS A C     1 
ATOM   1069 O  O     . LYS A 1 171 ? 5.28500  -23.81300 -2.87800  1.000 61.14040  ? 1587 LYS A O     1 
ATOM   1070 C  CB    . LYS A 1 171 ? 6.45700  -26.52100 -1.47300  1.000 67.07875  ? 1587 LYS A CB    1 
ATOM   1071 C  CG    . LYS A 1 171 ? 6.78300  -27.85800 -2.19700  1.000 87.22774  ? 1587 LYS A CG    1 
ATOM   1072 C  CD    . LYS A 1 171 ? 8.11500  -28.49500 -1.74400  1.000 94.51283  ? 1587 LYS A CD    1 
ATOM   1073 C  CE    . LYS A 1 171 ? 8.92400  -29.11900 -2.90200  1.000 82.55350  ? 1587 LYS A CE    1 
ATOM   1074 N  NZ    . LYS A 1 171 ? 10.34900 -29.36300 -2.48500  1.000 85.83547  ? 1587 LYS A NZ    1 
ATOM   1075 N  N     . GLU A 1 172 ? 6.38000  -23.21400 -1.02100  1.000 57.54570  ? 1588 GLU A N     1 
ATOM   1076 C  CA    . GLU A 1 172 ? 5.65900  -21.94300 -1.06100  1.000 62.85214  ? 1588 GLU A CA    1 
ATOM   1077 C  C     . GLU A 1 172 ? 6.23800  -20.99600 -2.10900  1.000 56.34954  ? 1588 GLU A C     1 
ATOM   1078 O  O     . GLU A 1 172 ? 5.51200  -20.15100 -2.64400  1.000 52.77078  ? 1588 GLU A O     1 
ATOM   1079 C  CB    . GLU A 1 172 ? 5.64400  -21.26800 0.31000   1.000 56.67671  ? 1588 GLU A CB    1 
ATOM   1080 C  CG    . GLU A 1 172 ? 4.93900  -19.90700 0.33100   1.000 61.12956  ? 1588 GLU A CG    1 
ATOM   1081 C  CD    . GLU A 1 172 ? 3.41500  -20.00400 0.29800   1.000 70.88631  ? 1588 GLU A CD    1 
ATOM   1082 O  OE1   . GLU A 1 172 ? 2.88400  -21.11900 0.11200   1.000 80.32691  ? 1588 GLU A OE1   1 
ATOM   1083 O  OE2   . GLU A 1 172 ? 2.74400  -18.95900 0.44100   1.000 70.86262  ? 1588 GLU A OE2   1 
ATOM   1084 N  N     . PHE A 1 173 ? 7.52600  -21.12200 -2.43200  1.000 50.94080  ? 1589 PHE A N     1 
ATOM   1085 C  CA    . PHE A 1 173 ? 8.09400  -20.28800 -3.48500  1.000 52.29751  ? 1589 PHE A CA    1 
ATOM   1086 C  C     . PHE A 1 173 ? 7.37600  -20.53700 -4.81000  1.000 55.97931  ? 1589 PHE A C     1 
ATOM   1087 O  O     . PHE A 1 173 ? 6.96300  -19.59300 -5.49100  1.000 53.72696  ? 1589 PHE A O     1 
ATOM   1088 C  CB    . PHE A 1 173 ? 9.59100  -20.55800 -3.63500  1.000 48.88152  ? 1589 PHE A CB    1 
ATOM   1089 C  CG    . PHE A 1 173 ? 10.16800 -20.02300 -4.93000  1.000 52.67078  ? 1589 PHE A CG    1 
ATOM   1090 C  CD1   . PHE A 1 173 ? 10.22900 -18.65300 -5.16100  1.000 49.47517  ? 1589 PHE A CD1   1 
ATOM   1091 C  CD2   . PHE A 1 173 ? 10.62700 -20.87900 -5.90800  1.000 53.34819  ? 1589 PHE A CD2   1 
ATOM   1092 C  CE1   . PHE A 1 173 ? 10.74700 -18.15300 -6.33000  1.000 50.47603  ? 1589 PHE A CE1   1 
ATOM   1093 C  CE2   . PHE A 1 173 ? 11.14900 -20.38300 -7.10900  1.000 57.62042  ? 1589 PHE A CE2   1 
ATOM   1094 C  CZ    . PHE A 1 173 ? 11.21000 -19.02000 -7.31300  1.000 52.33093  ? 1589 PHE A CZ    1 
ATOM   1095 N  N     . LYS A 1 174 ? 7.17300  -21.80800 -5.15900  1.000 50.98846  ? 1590 LYS A N     1 
ATOM   1096 C  CA    . LYS A 1 174 ? 6.46700  -22.13600 -6.39500  1.000 55.42626  ? 1590 LYS A CA    1 
ATOM   1097 C  C     . LYS A 1 174 ? 5.03100  -21.63000 -6.36600  1.000 55.93452  ? 1590 LYS A C     1 
ATOM   1098 O  O     . LYS A 1 174 ? 4.51400  -21.15500 -7.38300  1.000 50.20751  ? 1590 LYS A O     1 
ATOM   1099 C  CB    . LYS A 1 174 ? 6.49300  -23.64000 -6.63700  1.000 50.30961  ? 1590 LYS A CB    1 
ATOM   1100 C  CG    . LYS A 1 174 ? 7.86700  -24.19500 -6.95700  1.000 54.10039  ? 1590 LYS A CG    1 
ATOM   1101 C  CD    . LYS A 1 174 ? 7.81000  -25.68700 -7.33200  1.000 58.21536  ? 1590 LYS A CD    1 
ATOM   1102 C  CE    . LYS A 1 174 ? 7.75300  -26.58800 -6.11800  1.000 66.37281  ? 1590 LYS A CE    1 
ATOM   1103 N  NZ    . LYS A 1 174 ? 8.00600  -27.98000 -6.52400  1.000 67.96097  ? 1590 LYS A NZ    1 
ATOM   1104 N  N     . ALA A 1 175 ? 4.37100  -21.71400 -5.21000  1.000 49.53375  ? 1591 ALA A N     1 
ATOM   1105 C  CA    . ALA A 1 175 ? 3.00500  -21.21100 -5.11800  1.000 52.60254  ? 1591 ALA A CA    1 
ATOM   1106 C  C     . ALA A 1 175 ? 2.94500  -19.70600 -5.37000  1.000 52.46048  ? 1591 ALA A C     1 
ATOM   1107 O  O     . ALA A 1 175 ? 2.01000  -19.21700 -6.01600  1.000 55.23053  ? 1591 ALA A O     1 
ATOM   1108 C  CB    . ALA A 1 175 ? 2.41100  -21.55800 -3.75500  1.000 52.88701  ? 1591 ALA A CB    1 
ATOM   1109 N  N     . ARG A 1 176 ? 3.93700  -18.95500 -4.87700  1.000 52.01149  ? 1592 ARG A N     1 
ATOM   1110 C  CA    . ARG A 1 176 ? 3.94000  -17.51300 -5.09400  1.000 52.48488  ? 1592 ARG A CA    1 
ATOM   1111 C  C     . ARG A 1 176 ? 4.36500  -17.16300 -6.50700  1.000 50.59952  ? 1592 ARG A C     1 
ATOM   1112 O  O     . ARG A 1 176 ? 3.86700  -16.18200 -7.06800  1.000 52.67097  ? 1592 ARG A O     1 
ATOM   1113 C  CB    . ARG A 1 176 ? 4.85200  -16.82200 -4.08600  1.000 51.92139  ? 1592 ARG A CB    1 
ATOM   1114 C  CG    . ARG A 1 176 ? 4.52500  -17.20300 -2.64600  1.000 51.45482  ? 1592 ARG A CG    1 
ATOM   1115 C  CD    . ARG A 1 176 ? 4.37700  -15.99100 -1.77400  1.000 55.77903  ? 1592 ARG A CD    1 
ATOM   1116 N  NE    . ARG A 1 176 ? 3.85100  -16.33300 -0.45900  1.000 56.55301  ? 1592 ARG A NE    1 
ATOM   1117 C  CZ    . ARG A 1 176 ? 4.05800  -15.59700 0.62600   1.000 57.86025  ? 1592 ARG A CZ    1 
ATOM   1118 N  NH1   . ARG A 1 176 ? 4.77800  -14.49300 0.53600   1.000 57.00539  ? 1592 ARG A NH1   1 
ATOM   1119 N  NH2   . ARG A 1 176 ? 3.53800  -15.95100 1.78600   1.000 61.84470  ? 1592 ARG A NH2   1 
ATOM   1120 N  N     . VAL A 1 177 ? 5.28600  -17.93600 -7.09200  1.000 48.66102  ? 1593 VAL A N     1 
ATOM   1121 C  CA    . VAL A 1 177 ? 5.59100  -17.75800 -8.50700  1.000 53.77799  ? 1593 VAL A CA    1 
ATOM   1122 C  C     . VAL A 1 177 ? 4.29900  -17.78500 -9.30300  1.000 55.30183  ? 1593 VAL A C     1 
ATOM   1123 O  O     . VAL A 1 177 ? 4.00800  -16.87300 -10.08700 1.000 50.82391  ? 1593 VAL A O     1 
ATOM   1124 C  CB    . VAL A 1 177 ? 6.57800  -18.83300 -8.99200  1.000 53.93148  ? 1593 VAL A CB    1 
ATOM   1125 C  CG1   . VAL A 1 177 ? 6.53500  -18.94300 -10.51000 1.000 54.72207  ? 1593 VAL A CG1   1 
ATOM   1126 C  CG2   . VAL A 1 177 ? 7.99500  -18.50800 -8.51200  1.000 52.28296  ? 1593 VAL A CG2   1 
ATOM   1127 N  N     . LYS A 1 178 ? 3.46500  -18.79000 -9.04100  1.000 55.65998  ? 1594 LYS A N     1 
ATOM   1128 C  CA    . LYS A 1 178 ? 2.20600  -18.91100 -9.76400  1.000 57.28535  ? 1594 LYS A CA    1 
ATOM   1129 C  C     . LYS A 1 178 ? 1.29800  -17.73200 -9.46500  1.000 52.34077  ? 1594 LYS A C     1 
ATOM   1130 O  O     . LYS A 1 178 ? 0.70500  -17.15200 -10.38400 1.000 53.98427  ? 1594 LYS A O     1 
ATOM   1131 C  CB    . LYS A 1 178 ? 1.50900  -20.23200 -9.41900  1.000 56.30971  ? 1594 LYS A CB    1 
ATOM   1132 C  CG    . LYS A 1 178 ? 0.14100  -20.34900 -10.04200 1.000 59.76174  ? 1594 LYS A CG    1 
ATOM   1133 C  CD    . LYS A 1 178 ? -0.24600 -21.78800 -10.30000 1.000 57.13914  ? 1594 LYS A CD    1 
ATOM   1134 C  CE    . LYS A 1 178 ? -1.06800 -22.31600 -9.15200  1.000 61.35269  ? 1594 LYS A CE    1 
ATOM   1135 N  NZ    . LYS A 1 178 ? -1.54200 -23.68800 -9.36300  1.000 59.80340  ? 1594 LYS A NZ    1 
ATOM   1136 N  N     . GLU A 1 179 ? 1.20100  -17.33400 -8.19200  1.000 48.11731  ? 1595 GLU A N     1 
ATOM   1137 C  CA    . GLU A 1 179 ? 0.28100  -16.25100 -7.83900  1.000 55.43378  ? 1595 GLU A CA    1 
ATOM   1138 C  C     . GLU A 1 179 ? 0.70800  -14.92000 -8.44000  1.000 55.70483  ? 1595 GLU A C     1 
ATOM   1139 O  O     . GLU A 1 179 ? -0.13100 -14.15000 -8.92500  1.000 55.93506  ? 1595 GLU A O     1 
ATOM   1140 C  CB    . GLU A 1 179 ? 0.16800  -16.09900 -6.32700  1.000 53.40638  ? 1595 GLU A CB    1 
ATOM   1141 C  CG    . GLU A 1 179 ? -0.79700 -14.99600 -5.93300  1.000 59.66030  ? 1595 GLU A CG    1 
ATOM   1142 C  CD    . GLU A 1 179 ? -0.78200 -14.70800 -4.44300  1.000 82.14555  ? 1595 GLU A CD    1 
ATOM   1143 O  OE1   . GLU A 1 179 ? -0.22500 -15.52700 -3.68200  1.000 86.64083  ? 1595 GLU A OE1   1 
ATOM   1144 O  OE2   . GLU A 1 179 ? -1.33200 -13.66200 -4.03500  1.000 91.96515  ? 1595 GLU A OE2   1 
ATOM   1145 N  N     . TYR A 1 180 ? 1.99800  -14.60700 -8.37500  1.000 54.25082  ? 1596 TYR A N     1 
ATOM   1146 C  CA    . TYR A 1 180 ? 2.45500  -13.32100 -8.87800  1.000 52.32276  ? 1596 TYR A CA    1 
ATOM   1147 C  C     . TYR A 1 180 ? 2.33500  -13.27700 -10.39300 1.000 52.42300  ? 1596 TYR A C     1 
ATOM   1148 O  O     . TYR A 1 180 ? 1.97200  -12.24200 -10.96500 1.000 53.53104  ? 1596 TYR A O     1 
ATOM   1149 C  CB    . TYR A 1 180 ? 3.89500  -13.06400 -8.42600  1.000 51.11735  ? 1596 TYR A CB    1 
ATOM   1150 C  CG    . TYR A 1 180 ? 4.07200  -13.03300 -6.91000  1.000 52.02781  ? 1596 TYR A CG    1 
ATOM   1151 C  CD1   . TYR A 1 180 ? 2.99400  -12.75500 -6.07600  1.000 52.95596  ? 1596 TYR A CD1   1 
ATOM   1152 C  CD2   . TYR A 1 180 ? 5.32500  -13.26200 -6.32300  1.000 49.34826  ? 1596 TYR A CD2   1 
ATOM   1153 C  CE1   . TYR A 1 180 ? 3.14600  -12.71000 -4.69600  1.000 54.04863  ? 1596 TYR A CE1   1 
ATOM   1154 C  CE2   . TYR A 1 180 ? 5.49100  -13.21700 -4.95200  1.000 49.80397  ? 1596 TYR A CE2   1 
ATOM   1155 C  CZ    . TYR A 1 180 ? 4.39000  -12.94600 -4.14100  1.000 49.18874  ? 1596 TYR A CZ    1 
ATOM   1156 O  OH    . TYR A 1 180 ? 4.52700  -12.88500 -2.78100  1.000 51.91869  ? 1596 TYR A OH    1 
ATOM   1157 N  N     . ALA A 1 181 ? 2.59800  -14.40600 -11.05200 1.000 47.92929  ? 1597 ALA A N     1 
ATOM   1158 C  CA    . ALA A 1 181 ? 2.43700  -14.47700 -12.49900 1.000 53.53952  ? 1597 ALA A CA    1 
ATOM   1159 C  C     . ALA A 1 181 ? 0.97800  -14.29900 -12.89400 1.000 53.57657  ? 1597 ALA A C     1 
ATOM   1160 O  O     . ALA A 1 181 ? 0.66100  -13.50500 -13.78600 1.000 60.46171  ? 1597 ALA A O     1 
ATOM   1161 C  CB    . ALA A 1 181 ? 2.98400  -15.80300 -13.02800 1.000 56.06678  ? 1597 ALA A CB    1 
ATOM   1162 N  N     . ARG A 1 182 ? 0.06800  -15.00600 -12.22400 1.000 56.76224  ? 1598 ARG A N     1 
ATOM   1163 C  CA    . ARG A 1 182 ? -1.33900 -14.86500 -12.57600 1.000 59.09791  ? 1598 ARG A CA    1 
ATOM   1164 C  C     . ARG A 1 182 ? -1.87600 -13.48000 -12.22700 1.000 60.70567  ? 1598 ARG A C     1 
ATOM   1165 O  O     . ARG A 1 182 ? -2.83200 -13.01500 -12.85800 1.000 60.40714  ? 1598 ARG A O     1 
ATOM   1166 C  CB    . ARG A 1 182 ? -2.16800 -15.95800 -11.90600 1.000 67.20052  ? 1598 ARG A CB    1 
ATOM   1167 C  CG    . ARG A 1 182 ? -2.38600 -17.17300 -12.82000 1.000 77.47271  ? 1598 ARG A CG    1 
ATOM   1168 C  CD    . ARG A 1 182 ? -3.71100 -17.88000 -12.56100 1.000 87.74059  ? 1598 ARG A CD    1 
ATOM   1169 N  NE    . ARG A 1 182 ? -3.48700 -18.95300 -11.60200 1.000 94.51283  ? 1598 ARG A NE    1 
ATOM   1170 C  CZ    . ARG A 1 182 ? -3.90300 -18.91300 -10.34100 1.000 93.69431  ? 1598 ARG A CZ    1 
ATOM   1171 N  NH1   . ARG A 1 182 ? -4.58100 -17.86100 -9.90600  1.000 95.69028  ? 1598 ARG A NH1   1 
ATOM   1172 N  NH2   . ARG A 1 182 ? -3.64200 -19.91200 -9.51100  1.000 95.91563  ? 1598 ARG A NH2   1 
ATOM   1173 N  N     . ASN A 1 183 ? -1.27900 -12.80000 -11.23800 1.000 59.70039  ? 1599 ASN A N     1 
ATOM   1174 C  CA    . ASN A 1 183 ? -1.68700 -11.43100 -10.92900 1.000 57.15835  ? 1599 ASN A CA    1 
ATOM   1175 C  C     . ASN A 1 183 ? -1.08400 -10.42300 -11.89000 1.000 56.34574  ? 1599 ASN A C     1 
ATOM   1176 O  O     . ASN A 1 183 ? -1.53300 -9.26900  -11.92300 1.000 56.99848  ? 1599 ASN A O     1 
ATOM   1177 C  CB    . ASN A 1 183 ? -1.29400 -11.04700 -9.49500  1.000 54.60562  ? 1599 ASN A CB    1 
ATOM   1178 C  CG    . ASN A 1 183 ? -2.16100 -11.71700 -8.46200  1.000 63.40707  ? 1599 ASN A CG    1 
ATOM   1179 O  OD1   . ASN A 1 183 ? -2.99000 -12.56200 -8.79800  1.000 72.30753  ? 1599 ASN A OD1   1 
ATOM   1180 N  ND2   . ASN A 1 183 ? -1.97800 -11.35000 -7.19500  1.000 62.48396  ? 1599 ASN A ND2   1 
ATOM   1181 N  N     . LYS A 1 184 ? -0.07200 -10.83800 -12.65000 1.000 53.87425  ? 1600 LYS A N     1 
ATOM   1182 C  CA    . LYS A 1 184 ? 0.62000  -9.99200  -13.62400 1.000 56.80320  ? 1600 LYS A CA    1 
ATOM   1183 C  C     . LYS A 1 184 ? 1.39300  -8.87100  -12.93100 1.000 53.20261  ? 1600 LYS A C     1 
ATOM   1184 O  O     . LYS A 1 184 ? 1.44600  -7.74300  -13.42600 1.000 51.61143  ? 1600 LYS A O     1 
ATOM   1185 C  CB    . LYS A 1 184 ? -0.33800 -9.42800  -14.68400 1.000 56.67160  ? 1600 LYS A CB    1 
ATOM   1186 C  CG    . LYS A 1 184 ? -1.01700 -10.47500 -15.55200 1.000 62.66691  ? 1600 LYS A CG    1 
ATOM   1187 C  CD    . LYS A 1 184 ? -2.29900 -9.93000  -16.18500 1.000 71.59955  ? 1600 LYS A CD    1 
ATOM   1188 C  CE    . LYS A 1 184 ? -3.20500 -11.04500 -16.70500 1.000 78.09770  ? 1600 LYS A CE    1 
ATOM   1189 N  NZ    . LYS A 1 184 ? -4.35100 -11.28400 -15.78700 1.000 87.50146  ? 1600 LYS A NZ    1 
ATOM   1190 N  N     . ASN A 1 185 ? 1.99100  -9.18500  -11.77700 1.000 50.34511  ? 1601 ASN A N     1 
ATOM   1191 C  CA    . ASN A 1 185 ? 2.88700  -8.23700  -11.12800 1.000 51.88602  ? 1601 ASN A CA    1 
ATOM   1192 C  C     . ASN A 1 185 ? 3.99400  -7.82400  -12.08500 1.000 49.07655  ? 1601 ASN A C     1 
ATOM   1193 O  O     . ASN A 1 185 ? 4.47000  -8.61600  -12.90400 1.000 48.86554  ? 1601 ASN A O     1 
ATOM   1194 C  CB    . ASN A 1 185 ? 3.54200  -8.82500  -9.87500  1.000 48.66535  ? 1601 ASN A CB    1 
ATOM   1195 C  CG    . ASN A 1 185 ? 2.54800  -9.26600  -8.84400  1.000 50.06305  ? 1601 ASN A CG    1 
ATOM   1196 O  OD1   . ASN A 1 185 ? 1.34600  -9.08900  -9.01100  1.000 53.47106  ? 1601 ASN A OD1   1 
ATOM   1197 N  ND2   . ASN A 1 185 ? 3.04800  -9.85800  -7.76000  1.000 47.51772  ? 1601 ASN A ND2   1 
ATOM   1198 N  N     . ILE A 1 186 ? 4.40900  -6.56900  -11.96000 1.000 48.92180  ? 1602 ILE A N     1 
ATOM   1199 C  CA    . ILE A 1 186 ? 5.57200  -6.07600  -12.67900 1.000 49.27267  ? 1602 ILE A CA    1 
ATOM   1200 C  C     . ILE A 1 186 ? 6.83400  -6.25800  -11.85600 1.000 48.07414  ? 1602 ILE A C     1 
ATOM   1201 O  O     . ILE A 1 186 ? 7.83400  -6.78900  -12.34300 1.000 48.72948  ? 1602 ILE A O     1 
ATOM   1202 C  CB    . ILE A 1 186 ? 5.35900  -4.60100  -13.05600 1.000 50.93951  ? 1602 ILE A CB    1 
ATOM   1203 C  CG1   . ILE A 1 186 ? 3.99700  -4.43100  -13.72800 1.000 55.16436  ? 1602 ILE A CG1   1 
ATOM   1204 C  CG2   . ILE A 1 186 ? 6.52500  -4.12600  -13.91900 1.000 49.55661  ? 1602 ILE A CG2   1 
ATOM   1205 C  CD1   . ILE A 1 186 ? 3.84000  -3.13100  -14.49900 1.000 56.61834  ? 1602 ILE A CD1   1 
ATOM   1206 N  N     . HIS A 1 187 ? 6.81500  -5.81100  -10.60200 1.000 49.49414  ? 1603 HIS A N     1 
ATOM   1207 C  CA    . HIS A 1 187 ? 7.99200  -5.87500  -9.74800  1.000 48.13841  ? 1603 HIS A CA    1 
ATOM   1208 C  C     . HIS A 1 187 ? 8.05000  -7.23200  -9.06800  1.000 45.66586  ? 1603 HIS A C     1 
ATOM   1209 O  O     . HIS A 1 187 ? 7.01800  -7.79500  -8.69800  1.000 43.06382  ? 1603 HIS A O     1 
ATOM   1210 C  CB    . HIS A 1 187 ? 7.96900  -4.75100  -8.70100  1.000 46.28291  ? 1603 HIS A CB    1 
ATOM   1211 C  CG    . HIS A 1 187 ? 7.87400  -3.38200  -9.30100  1.000 51.71751  ? 1603 HIS A CG    1 
ATOM   1212 N  ND1   . HIS A 1 187 ? 8.82100  -2.88600  -10.17100 1.000 50.45957  ? 1603 HIS A ND1   1 
ATOM   1213 C  CD2   . HIS A 1 187 ? 6.92100  -2.42800  -9.20000  1.000 50.50540  ? 1603 HIS A CD2   1 
ATOM   1214 C  CE1   . HIS A 1 187 ? 8.46500  -1.67600  -10.56600 1.000 50.60114  ? 1603 HIS A CE1   1 
ATOM   1215 N  NE2   . HIS A 1 187 ? 7.31500  -1.37500  -9.99000  1.000 50.77923  ? 1603 HIS A NE2   1 
ATOM   1216 N  N     . TYR A 1 188 ? 9.25700  -7.77200  -8.93400  1.000 45.53830  ? 1604 TYR A N     1 
ATOM   1217 C  CA    . TYR A 1 188 ? 9.46300  -9.00800  -8.19600  1.000 46.54949  ? 1604 TYR A CA    1 
ATOM   1218 C  C     . TYR A 1 188 ? 10.45800 -8.75600  -7.08000  1.000 43.56488  ? 1604 TYR A C     1 
ATOM   1219 O  O     . TYR A 1 188 ? 11.31600 -7.87200  -7.17400  1.000 38.62217  ? 1604 TYR A O     1 
ATOM   1220 C  CB    . TYR A 1 188 ? 9.95200  -10.15200 -9.08300  1.000 42.42711  ? 1604 TYR A CB    1 
ATOM   1221 C  CG    . TYR A 1 188 ? 8.80700  -10.81000 -9.80700  1.000 45.59865  ? 1604 TYR A CG    1 
ATOM   1222 C  CD1   . TYR A 1 188 ? 8.21900  -10.20300 -10.92800 1.000 46.04712  ? 1604 TYR A CD1   1 
ATOM   1223 C  CD2   . TYR A 1 188 ? 8.28100  -11.99700 -9.35700  1.000 46.10922  ? 1604 TYR A CD2   1 
ATOM   1224 C  CE1   . TYR A 1 188 ? 7.14600  -10.79600 -11.56600 1.000 49.64174  ? 1604 TYR A CE1   1 
ATOM   1225 C  CE2   . TYR A 1 188 ? 7.22700  -12.59900 -9.99400  1.000 47.53333  ? 1604 TYR A CE2   1 
ATOM   1226 C  CZ    . TYR A 1 188 ? 6.66600  -12.00200 -11.09500 1.000 47.26634  ? 1604 TYR A CZ    1 
ATOM   1227 O  OH    . TYR A 1 188 ? 5.60900  -12.60800 -11.70400 1.000 55.85030  ? 1604 TYR A OH    1 
ATOM   1228 N  N     . TYR A 1 189 ? 10.33400 -9.55200  -6.02400  1.000 44.03593  ? 1605 TYR A N     1 
ATOM   1229 C  CA    . TYR A 1 189 ? 11.01100 -9.22000  -4.78400  1.000 41.68396  ? 1605 TYR A CA    1 
ATOM   1230 C  C     . TYR A 1 189 ? 11.60400 -10.45400 -4.13300  1.000 47.53030  ? 1605 TYR A C     1 
ATOM   1231 O  O     . TYR A 1 189 ? 11.65800 -10.53600 -2.90700  1.000 46.39127  ? 1605 TYR A O     1 
ATOM   1232 C  CB    . TYR A 1 189 ? 10.04800 -8.53600  -3.80200  1.000 45.20431  ? 1605 TYR A CB    1 
ATOM   1233 C  CG    . TYR A 1 189 ? 9.37100  -7.28100  -4.30800  1.000 47.48394  ? 1605 TYR A CG    1 
ATOM   1234 C  CD1   . TYR A 1 189 ? 8.19300  -7.34500  -5.05600  1.000 46.26201  ? 1605 TYR A CD1   1 
ATOM   1235 C  CD2   . TYR A 1 189 ? 9.91000  -6.02300  -4.03900  1.000 47.46722  ? 1605 TYR A CD2   1 
ATOM   1236 C  CE1   . TYR A 1 189 ? 7.57200  -6.17900  -5.51600  1.000 48.02373  ? 1605 TYR A CE1   1 
ATOM   1237 C  CE2   . TYR A 1 189 ? 9.29900  -4.86000  -4.48200  1.000 45.79125  ? 1605 TYR A CE2   1 
ATOM   1238 C  CZ    . TYR A 1 189 ? 8.13200  -4.93900  -5.21900  1.000 46.10439  ? 1605 TYR A CZ    1 
ATOM   1239 O  OH    . TYR A 1 189 ? 7.53600  -3.76800  -5.64800  1.000 48.48768  ? 1605 TYR A OH    1 
ATOM   1240 N  N     . PHE A 1 190 ? 12.03200 -11.42800 -4.93000  1.000 45.95931  ? 1606 PHE A N     1 
ATOM   1241 C  CA    . PHE A 1 190 ? 12.60300 -12.66900 -4.42000  1.000 47.87951  ? 1606 PHE A CA    1 
ATOM   1242 C  C     . PHE A 1 190 ? 14.11000 -12.51200 -4.25500  1.000 46.31231  ? 1606 PHE A C     1 
ATOM   1243 O  O     . PHE A 1 190 ? 14.82800 -12.25800 -5.23000  1.000 44.78911  ? 1606 PHE A O     1 
ATOM   1244 C  CB    . PHE A 1 190 ? 12.33700 -13.82700 -5.37800  1.000 51.72023  ? 1606 PHE A CB    1 
ATOM   1245 C  CG    . PHE A 1 190 ? 10.89700 -14.20000 -5.53500  1.000 48.26518  ? 1606 PHE A CG    1 
ATOM   1246 C  CD1   . PHE A 1 190 ? 10.10300 -14.46800 -4.43500  1.000 44.34608  ? 1606 PHE A CD1   1 
ATOM   1247 C  CD2   . PHE A 1 190 ? 10.35200 -14.35000 -6.80700  1.000 47.15733  ? 1606 PHE A CD2   1 
ATOM   1248 C  CE1   . PHE A 1 190 ? 8.78400  -14.84600 -4.58800  1.000 44.47944  ? 1606 PHE A CE1   1 
ATOM   1249 C  CE2   . PHE A 1 190 ? 9.03700  -14.73200 -6.96100  1.000 44.93846  ? 1606 PHE A CE2   1 
ATOM   1250 C  CZ    . PHE A 1 190 ? 8.25400  -14.98600 -5.84200  1.000 46.50707  ? 1606 PHE A CZ    1 
ATOM   1251 N  N     . MET A 1 191 ? 14.59400 -12.69500 -3.03700  1.000 46.18335  ? 1607 MET A N     1 
ATOM   1252 C  CA    . MET A 1 191 ? 16.02000 -12.80100 -2.76100  1.000 50.72834  ? 1607 MET A CA    1 
ATOM   1253 C  C     . MET A 1 191 ? 16.31700 -14.25500 -2.43200  1.000 54.26621  ? 1607 MET A C     1 
ATOM   1254 O  O     . MET A 1 191 ? 15.60600 -14.86000 -1.62400  1.000 60.22450  ? 1607 MET A O     1 
ATOM   1255 C  CB    . MET A 1 191 ? 16.41400 -11.87100 -1.60700  1.000 51.56820  ? 1607 MET A CB    1 
ATOM   1256 C  CG    . MET A 1 191 ? 17.87000 -11.92100 -1.16800  1.000 55.25022  ? 1607 MET A CG    1 
ATOM   1257 S  SD    . MET A 1 191 ? 18.91600 -10.75300 -2.06300  1.000 62.09407  ? 1607 MET A SD    1 
ATOM   1258 C  CE    . MET A 1 191 ? 18.14000 -9.18300  -1.71000  1.000 46.47966  ? 1607 MET A CE    1 
ATOM   1259 N  N     . ALA A 1 192 ? 17.33800 -14.81200 -3.07500  1.000 54.29889  ? 1608 ALA A N     1 
ATOM   1260 C  CA    . ALA A 1 192 ? 17.69800 -16.22600 -2.84900  1.000 60.78937  ? 1608 ALA A CA    1 
ATOM   1261 C  C     . ALA A 1 192 ? 19.05300 -16.29700 -2.15700  1.000 65.67162  ? 1608 ALA A C     1 
ATOM   1262 O  O     . ALA A 1 192 ? 20.05800 -16.47200 -2.85700  1.000 73.44714  ? 1608 ALA A O     1 
ATOM   1263 C  CB    . ALA A 1 192 ? 17.75900 -16.95500 -4.15400  1.000 56.53423  ? 1608 ALA A CB    1 
ATOM   1264 N  N     . PRO A 1 193 ? 19.11900 -16.16200 -0.82100  1.000 63.63129  ? 1609 PRO A N     1 
ATOM   1265 C  CA    . PRO A 1 193 ? 20.37900 -16.29000 -0.12800  1.000 77.19211  ? 1609 PRO A CA    1 
ATOM   1266 C  C     . PRO A 1 193 ? 21.04400 -17.58500 -0.59900  1.000 84.90157  ? 1609 PRO A C     1 
ATOM   1267 O  O     . PRO A 1 193 ? 20.38800 -18.60300 -0.64800  1.000 83.31095  ? 1609 PRO A O     1 
ATOM   1268 C  CB    . PRO A 1 193 ? 19.94400 -16.35700 1.33400   1.000 70.92895  ? 1609 PRO A CB    1 
ATOM   1269 C  CG    . PRO A 1 193 ? 18.69300 -15.53100 1.37800   1.000 64.42936  ? 1609 PRO A CG    1 
ATOM   1270 C  CD    . PRO A 1 193 ? 18.00900 -15.84700 0.06900   1.000 63.91462  ? 1609 PRO A CD    1 
ATOM   1271 N  N     . LYS A 1 194 ? 22.32800 -17.50900 -0.92800  1.000 89.07091  ? 1610 LYS A N     1 
ATOM   1272 C  CA    . LYS A 1 194 ? 23.04100 -18.69200 -1.47800  1.000 100.41353 ? 1610 LYS A CA    1 
ATOM   1273 C  C     . LYS A 1 194 ? 22.83800 -19.90400 -0.56400  1.000 102.08215 ? 1610 LYS A C     1 
ATOM   1274 O  O     . LYS A 1 194 ? 22.99200 -19.74900 0.66600   1.000 107.99865 ? 1610 LYS A O     1 
ATOM   1275 C  CB    . LYS A 1 194 ? 24.52200 -18.36200 -1.67900  1.000 108.29079 ? 1610 LYS A CB    1 
ATOM   1276 C  CG    . LYS A 1 194 ? 24.80500 -16.94600 -2.17000  1.000 112.04914 ? 1610 LYS A CG    1 
ATOM   1277 C  CD    . LYS A 1 194 ? 23.99200 -16.53000 -3.38500  1.000 106.45636 ? 1610 LYS A CD    1 
ATOM   1278 C  CE    . LYS A 1 194 ? 24.49400 -17.12300 -4.68400  1.000 111.25367 ? 1610 LYS A CE    1 
ATOM   1279 N  NZ    . LYS A 1 194 ? 23.57400 -18.16300 -5.20000  1.000 115.91013 ? 1610 LYS A NZ    1 
ATOM   1280 N  N     . ASN A 1 195 ? 22.48800 -21.05100 -1.15100  1.000 98.79713  ? 1611 ASN A N     1 
ATOM   1281 C  CA    . ASN A 1 195 ? 22.27000 -22.29300 -0.36700  1.000 99.38920  ? 1611 ASN A CA    1 
ATOM   1282 C  C     . ASN A 1 195 ? 21.20900 -22.04500 0.70500   1.000 99.55394  ? 1611 ASN A C     1 
ATOM   1283 O  O     . ASN A 1 195 ? 21.40100 -22.54300 1.82500   1.000 99.83059  ? 1611 ASN A O     1 
ATOM   1284 C  CB    . ASN A 1 195 ? 23.56900 -22.79500 0.26700   1.000 99.24616  ? 1611 ASN A CB    1 
ATOM   1285 C  CG    . ASN A 1 195 ? 23.72500 -24.29800 0.20500   1.000 104.44517 ? 1611 ASN A CG    1 
ATOM   1286 O  OD1   . ASN A 1 195 ? 22.79400 -25.04000 0.51300   1.000 110.88058 ? 1611 ASN A OD1   1 
ATOM   1287 N  ND2   . ASN A 1 195 ? 24.90200 -24.75600 -0.18800  1.000 107.06518 ? 1611 ASN A ND2   1 
ATOM   1288 N  N     . ASP A 1 196 ? 20.13800 -21.31300 0.38500   1.000 97.29395  ? 1612 ASP A N     1 
ATOM   1289 C  CA    . ASP A 1 196 ? 19.18800 -21.03400 1.45300   1.000 92.50995  ? 1612 ASP A CA    1 
ATOM   1290 C  C     . ASP A 1 196 ? 17.81800 -20.70100 0.88300   1.000 89.33326  ? 1612 ASP A C     1 
ATOM   1291 O  O     . ASP A 1 196 ? 17.62800 -20.57300 -0.32900  1.000 95.93405  ? 1612 ASP A O     1 
ATOM   1292 C  CB    . ASP A 1 196 ? 19.67900 -19.90700 2.36600   1.000 89.50649  ? 1612 ASP A CB    1 
ATOM   1293 C  CG    . ASP A 1 196 ? 19.54900 -20.26700 3.83300   1.000 92.20724  ? 1612 ASP A CG    1 
ATOM   1294 O  OD1   . ASP A 1 196 ? 18.56400 -20.95300 4.19900   1.000 89.40432  ? 1612 ASP A OD1   1 
ATOM   1295 O  OD2   . ASP A 1 196 ? 20.44700 -19.89600 4.61700   1.000 96.18145  ? 1612 ASP A OD2   1 
ATOM   1296 N  N     . GLU A 1 197 ? 16.86300 -20.56400 1.80100   1.000 82.46111  ? 1613 GLU A N     1 
ATOM   1297 C  CA    . GLU A 1 197 ? 15.47700 -20.31300 1.45500   1.000 77.79372  ? 1613 GLU A CA    1 
ATOM   1298 C  C     . GLU A 1 197 ? 15.31500 -18.91600 0.86700   1.000 70.85649  ? 1613 GLU A C     1 
ATOM   1299 O  O     . GLU A 1 197 ? 16.14300 -18.02400 1.06800   1.000 73.76297  ? 1613 GLU A O     1 
ATOM   1300 C  CB    . GLU A 1 197 ? 14.58300 -20.47300 2.68500   1.000 71.03566  ? 1613 GLU A CB    1 
ATOM   1301 C  CG    . GLU A 1 197 ? 15.04000 -21.57100 3.65700   1.000 83.31092  ? 1613 GLU A CG    1 
ATOM   1302 C  CD    . GLU A 1 197 ? 14.09400 -21.75100 4.84300   1.000 96.56570  ? 1613 GLU A CD    1 
ATOM   1303 O  OE1   . GLU A 1 197 ? 12.98800 -22.29900 4.64900   1.000 103.81921 ? 1613 GLU A OE1   1 
ATOM   1304 O  OE2   . GLU A 1 197 ? 14.45800 -21.35300 5.97400   1.000 104.51139 ? 1613 GLU A OE2   1 
ATOM   1305 N  N     . ILE A 1 198 ? 14.22500 -18.73700 0.14000   1.000 62.82646  ? 1614 ILE A N     1 
ATOM   1306 C  CA    . ILE A 1 198 ? 13.90300 -17.45100 -0.46900  1.000 57.24224  ? 1614 ILE A CA    1 
ATOM   1307 C  C     . ILE A 1 198 ? 13.39300 -16.47200 0.58200   1.000 55.28401  ? 1614 ILE A C     1 
ATOM   1308 O  O     . ILE A 1 198 ? 12.57700 -16.82200 1.44300   1.000 55.02125  ? 1614 ILE A O     1 
ATOM   1309 C  CB    . ILE A 1 198 ? 12.85200 -17.64100 -1.56500  1.000 56.66192  ? 1614 ILE A CB    1 
ATOM   1310 C  CG1   . ILE A 1 198 ? 13.37100 -18.61600 -2.63500  1.000 59.89025  ? 1614 ILE A CG1   1 
ATOM   1311 C  CG2   . ILE A 1 198 ? 12.46000 -16.28200 -2.11400  1.000 53.62410  ? 1614 ILE A CG2   1 
ATOM   1312 C  CD1   . ILE A 1 198 ? 14.15700 -17.93500 -3.74800  1.000 61.03513  ? 1614 ILE A CD1   1 
ATOM   1313 N  N     . ILE A 1 199 ? 13.85600 -15.23500 0.50400   1.000 52.22767  ? 1615 ILE A N     1 
ATOM   1314 C  CA    . ILE A 1 199 ? 13.24900 -14.11800 1.21400   1.000 50.03644  ? 1615 ILE A CA    1 
ATOM   1315 C  C     . ILE A 1 199 ? 12.37000 -13.35400 0.23100   1.000 49.79455  ? 1615 ILE A C     1 
ATOM   1316 O  O     . ILE A 1 199 ? 12.86800 -12.66900 -0.66800  1.000 44.59643  ? 1615 ILE A O     1 
ATOM   1317 C  CB    . ILE A 1 199 ? 14.29800 -13.18700 1.83300   1.000 45.44045  ? 1615 ILE A CB    1 
ATOM   1318 C  CG1   . ILE A 1 199 ? 15.23300 -13.94200 2.77700   1.000 52.38106  ? 1615 ILE A CG1   1 
ATOM   1319 C  CG2   . ILE A 1 199 ? 13.58700 -12.04100 2.52400   1.000 44.00582  ? 1615 ILE A CG2   1 
ATOM   1320 C  CD1   . ILE A 1 199 ? 16.38700 -13.09800 3.28300   1.000 47.53336  ? 1615 ILE A CD1   1 
ATOM   1321 N  N     . ASP A 1 200 ? 11.06100 -13.42100 0.43400   1.000 46.85142  ? 1616 ASP A N     1 
ATOM   1322 C  CA    . ASP A 1 200 ? 10.08700 -12.76000 -0.42800  1.000 47.11058  ? 1616 ASP A CA    1 
ATOM   1323 C  C     . ASP A 1 200 ? 9.59100  -11.48900 0.26200   1.000 49.01291  ? 1616 ASP A C     1 
ATOM   1324 O  O     . ASP A 1 200 ? 8.91400  -11.55600 1.29600   1.000 50.05602  ? 1616 ASP A O     1 
ATOM   1325 C  CB    . ASP A 1 200 ? 8.93800  -13.72400 -0.72900  1.000 47.40847  ? 1616 ASP A CB    1 
ATOM   1326 C  CG    . ASP A 1 200 ? 7.83400  -13.08200 -1.53500  1.000 49.84218  ? 1616 ASP A CG    1 
ATOM   1327 O  OD1   . ASP A 1 200 ? 8.06000  -11.98400 -2.06100  1.000 48.27771  ? 1616 ASP A OD1   1 
ATOM   1328 O  OD2   . ASP A 1 200 ? 6.74300  -13.68100 -1.65600  1.000 46.08252  ? 1616 ASP A OD2   1 
ATOM   1329 N  N     . ALA A 1 201 ? 9.93100  -10.33000 -0.29800  1.000 46.85626  ? 1617 ALA A N     1 
ATOM   1330 C  CA    . ALA A 1 201 ? 9.51500  -9.05800  0.27300   1.000 47.90445  ? 1617 ALA A CA    1 
ATOM   1331 C  C     . ALA A 1 201 ? 8.38900  -8.42100  -0.52200  1.000 47.09100  ? 1617 ALA A C     1 
ATOM   1332 O  O     . ALA A 1 201 ? 8.18400  -7.21700  -0.42600  1.000 49.79533  ? 1617 ALA A O     1 
ATOM   1333 C  CB    . ALA A 1 201 ? 10.69700 -8.09400  0.37800   1.000 45.87278  ? 1617 ALA A CB    1 
ATOM   1334 N  N     . THR A 1 202 ? 7.63600  -9.22100  -1.27300  1.000 47.49141  ? 1618 THR A N     1 
ATOM   1335 C  CA    . THR A 1 202 ? 6.56500  -8.70100  -2.11800  1.000 47.86446  ? 1618 THR A CA    1 
ATOM   1336 C  C     . THR A 1 202 ? 5.41100  -8.15000  -1.28900  1.000 49.54127  ? 1618 THR A C     1 
ATOM   1337 O  O     . THR A 1 202 ? 4.87100  -7.08900  -1.61000  1.000 51.12328  ? 1618 THR A O     1 
ATOM   1338 C  CB    . THR A 1 202 ? 6.06500  -9.81400  -3.04700  1.000 45.12530  ? 1618 THR A CB    1 
ATOM   1339 O  OG1   . THR A 1 202 ? 7.15600  -10.33700 -3.81300  1.000 47.29106  ? 1618 THR A OG1   1 
ATOM   1340 C  CG2   . THR A 1 202 ? 4.96400  -9.33000  -3.98100  1.000 47.58612  ? 1618 THR A CG2   1 
ATOM   1341 N  N     . GLN A 1 203 ? 5.00600  -8.85700  -0.22800  1.000 51.27240  ? 1619 GLN A N     1 
ATOM   1342 C  CA    . GLN A 1 203 ? 3.85600  -8.47300  0.59000   1.000 51.89301  ? 1619 GLN A CA    1 
ATOM   1343 C  C     . GLN A 1 203 ? 4.22700  -7.92000  1.95500   1.000 50.11549  ? 1619 GLN A C     1 
ATOM   1344 O  O     . GLN A 1 203 ? 3.51500  -7.06200  2.48600   1.000 52.20699  ? 1619 GLN A O     1 
ATOM   1345 C  CB    . GLN A 1 203 ? 2.92100  -9.67000  0.80100   1.000 54.72351  ? 1619 GLN A CB    1 
ATOM   1346 C  CG    . GLN A 1 203 ? 2.65200  -10.47200 -0.46200  1.000 58.94540  ? 1619 GLN A CG    1 
ATOM   1347 C  CD    . GLN A 1 203 ? 1.66900  -11.62000 -0.24100  1.000 68.90976  ? 1619 GLN A CD    1 
ATOM   1348 O  OE1   . GLN A 1 203 ? 0.70100  -11.48700 0.50500   1.000 78.27667  ? 1619 GLN A OE1   1 
ATOM   1349 N  NE2   . GLN A 1 203 ? 1.92300  -12.75700 -0.88900  1.000 69.44666  ? 1619 GLN A NE2   1 
ATOM   1350 N  N     . LYS A 1 204 ? 5.31300  -8.40200  2.53700   1.000 49.38951  ? 1620 LYS A N     1 
ATOM   1351 C  CA    . LYS A 1 204 ? 5.82400  -7.89700  3.79700   1.000 52.83817  ? 1620 LYS A CA    1 
ATOM   1352 C  C     . LYS A 1 204 ? 7.30800  -7.60800  3.62800   1.000 45.77277  ? 1620 LYS A C     1 
ATOM   1353 O  O     . LYS A 1 204 ? 8.02200  -8.37000  2.96900   1.000 55.08968  ? 1620 LYS A O     1 
ATOM   1354 C  CB    . LYS A 1 204 ? 5.59300  -8.91900  4.92100   1.000 54.37567  ? 1620 LYS A CB    1 
ATOM   1355 C  CG    . LYS A 1 204 ? 4.20000  -9.55600  4.89100   1.000 54.45987  ? 1620 LYS A CG    1 
ATOM   1356 C  CD    . LYS A 1 204 ? 3.86000  -10.29500 6.20700   1.000 56.57327  ? 1620 LYS A CD    1 
ATOM   1357 C  CE    . LYS A 1 204 ? 2.42300  -10.82100 6.18000   1.000 58.10193  ? 1620 LYS A CE    1 
ATOM   1358 N  NZ    . LYS A 1 204 ? 2.06300  -11.52500 7.45900   1.000 64.83168  ? 1620 LYS A NZ    1 
ATOM   1359 N  N     . GLY A 1 205 ? 7.76700  -6.49700  4.19100   1.000 44.83426  ? 1621 GLY A N     1 
ATOM   1360 C  CA    . GLY A 1 205 ? 9.17500  -6.16200  4.09700   1.000 42.80970  ? 1621 GLY A CA    1 
ATOM   1361 C  C     . GLY A 1 205 ? 9.42000  -4.79900  4.70100   1.000 45.05689  ? 1621 GLY A C     1 
ATOM   1362 O  O     . GLY A 1 205 ? 8.58200  -4.27500  5.43800   1.000 47.94000  ? 1621 GLY A O     1 
ATOM   1363 N  N     . ASN A 1 206 ? 10.57700 -4.23000  4.38100   1.000 42.21002  ? 1622 ASN A N     1 
ATOM   1364 C  CA    . ASN A 1 206 ? 10.79000 -2.84100  4.75900   1.000 48.08760  ? 1622 ASN A CA    1 
ATOM   1365 C  C     . ASN A 1 206 ? 11.16500 -2.04600  3.50800   1.000 44.90563  ? 1622 ASN A C     1 
ATOM   1366 O  O     . ASN A 1 206 ? 11.03500 -2.54900  2.38400   1.000 41.64587  ? 1622 ASN A O     1 
ATOM   1367 C  CB    . ASN A 1 206 ? 11.84000 -2.73300  5.88400   1.000 43.96942  ? 1622 ASN A CB    1 
ATOM   1368 C  CG    . ASN A 1 206 ? 13.18700 -3.28500  5.48800   1.000 47.40545  ? 1622 ASN A CG    1 
ATOM   1369 O  OD1   . ASN A 1 206 ? 13.54700 -3.27600  4.31600   1.000 44.30746  ? 1622 ASN A OD1   1 
ATOM   1370 N  ND2   . ASN A 1 206 ? 13.96100 -3.73900  6.47200   1.000 39.83190  ? 1622 ASN A ND2   1 
ATOM   1371 N  N     . CYS A 1 207 ? 11.61900 -0.81200  3.67000   1.000 42.21708  ? 1623 CYS A N     1 
ATOM   1372 C  CA    . CYS A 1 207 ? 11.92600 -0.00900  2.48800   1.000 48.92643  ? 1623 CYS A CA    1 
ATOM   1373 C  C     . CYS A 1 207 ? 13.13600 -0.50100  1.70100   1.000 45.26588  ? 1623 CYS A C     1 
ATOM   1374 O  O     . CYS A 1 207 ? 13.42100 0.05700   0.64400   1.000 40.25137  ? 1623 CYS A O     1 
ATOM   1375 C  CB    . CYS A 1 207 ? 12.14400 1.45400   2.87600   1.000 48.05199  ? 1623 CYS A CB    1 
ATOM   1376 S  SG    . CYS A 1 207 ? 10.62900 2.28400   3.41400   1.000 54.50030  ? 1623 CYS A SG    1 
ATOM   1377 N  N     . SER A 1 208 ? 13.86600 -1.50500  2.17300   1.000 46.48488  ? 1624 SER A N     1 
ATOM   1378 C  CA    . SER A 1 208 ? 14.94300 -2.02900  1.34900   1.000 40.23976  ? 1624 SER A CA    1 
ATOM   1379 C  C     . SER A 1 208 ? 14.41600 -2.71100  0.09200   1.000 44.29986  ? 1624 SER A C     1 
ATOM   1380 O  O     . SER A 1 208 ? 15.19200 -2.95200  -0.83100  1.000 40.92745  ? 1624 SER A O     1 
ATOM   1381 C  CB    . SER A 1 208 ? 15.75800 -3.05500  2.11200   1.000 43.83270  ? 1624 SER A CB    1 
ATOM   1382 O  OG    . SER A 1 208 ? 14.99100 -4.23700  2.27900   1.000 39.41279  ? 1624 SER A OG    1 
ATOM   1383 N  N     . ARG A 1 209 ? 13.13100 -3.08100  0.07000   1.000 42.07744  ? 1625 ARG A N     1 
ATOM   1384 C  CA    . ARG A 1 209 ? 12.51600 -3.72400  -1.07400  1.000 42.97579  ? 1625 ARG A CA    1 
ATOM   1385 C  C     . ARG A 1 209 ? 12.42600 -2.77300  -2.25600  1.000 44.68843  ? 1625 ARG A C     1 
ATOM   1386 O  O     . ARG A 1 209 ? 12.03400 -3.19500  -3.34800  1.000 43.49157  ? 1625 ARG A O     1 
ATOM   1387 C  CB    . ARG A 1 209 ? 11.12100 -4.23200  -0.70600  1.000 37.92109  ? 1625 ARG A CB    1 
ATOM   1388 C  CG    . ARG A 1 209 ? 10.07300 -3.10500  -0.59100  1.000 45.33834  ? 1625 ARG A CG    1 
ATOM   1389 C  CD    . ARG A 1 209 ? 8.77300  -3.54000  0.11200   1.000 46.15896  ? 1625 ARG A CD    1 
ATOM   1390 N  NE    . ARG A 1 209 ? 7.88000  -4.35000  -0.72600  1.000 46.84058  ? 1625 ARG A NE    1 
ATOM   1391 C  CZ    . ARG A 1 209 ? 7.05900  -3.86400  -1.66700  1.000 54.00797  ? 1625 ARG A CZ    1 
ATOM   1392 N  NH1   . ARG A 1 209 ? 7.01400  -2.55400  -1.92500  1.000 47.47034  ? 1625 ARG A NH1   1 
ATOM   1393 N  NH2   . ARG A 1 209 ? 6.28900  -4.69500  -2.37100  1.000 46.60462  ? 1625 ARG A NH2   1 
ATOM   1394 N  N     . PHE A 1 210 ? 12.77800 -1.50800  -2.05300  1.000 46.25170  ? 1626 PHE A N     1 
ATOM   1395 C  CA    . PHE A 1 210 ? 12.78000 -0.50900  -3.10300  1.000 42.14427  ? 1626 PHE A CA    1 
ATOM   1396 C  C     . PHE A 1 210 ? 14.13800 -0.35300  -3.77100  1.000 43.26870  ? 1626 PHE A C     1 
ATOM   1397 O  O     . PHE A 1 210 ? 14.27400 0.48900   -4.65400  1.000 45.52391  ? 1626 PHE A O     1 
ATOM   1398 C  CB    . PHE A 1 210 ? 12.31500 0.84000   -2.53400  1.000 46.39167  ? 1626 PHE A CB    1 
ATOM   1399 C  CG    . PHE A 1 210 ? 10.87000 0.84300   -2.11300  1.000 46.06496  ? 1626 PHE A CG    1 
ATOM   1400 C  CD1   . PHE A 1 210 ? 9.86600  0.62600   -3.04600  1.000 42.76164  ? 1626 PHE A CD1   1 
ATOM   1401 C  CD2   . PHE A 1 210 ? 10.51700 1.04100   -0.78600  1.000 40.44689  ? 1626 PHE A CD2   1 
ATOM   1402 C  CE1   . PHE A 1 210 ? 8.54100  0.61900   -2.67300  1.000 43.89697  ? 1626 PHE A CE1   1 
ATOM   1403 C  CE2   . PHE A 1 210 ? 9.18800  1.03600   -0.40000  1.000 43.56689  ? 1626 PHE A CE2   1 
ATOM   1404 C  CZ    . PHE A 1 210 ? 8.19600  0.81300   -1.34100  1.000 50.57861  ? 1626 PHE A CZ    1 
ATOM   1405 N  N     . MET A 1 211 ? 15.14600 -1.12200  -3.37500  1.000 42.20057  ? 1627 MET A N     1 
ATOM   1406 C  CA    . MET A 1 211 ? 16.47300 -0.90000  -3.92000  1.000 46.04084  ? 1627 MET A CA    1 
ATOM   1407 C  C     . MET A 1 211 ? 16.53500 -1.46900  -5.33000  1.000 47.45673  ? 1627 MET A C     1 
ATOM   1408 O  O     . MET A 1 211 ? 16.33800 -2.66900  -5.52900  1.000 37.42514  ? 1627 MET A O     1 
ATOM   1409 C  CB    . MET A 1 211 ? 17.54800 -1.53300  -3.05000  1.000 43.41975  ? 1627 MET A CB    1 
ATOM   1410 C  CG    . MET A 1 211 ? 18.96000 -1.14100  -3.54500  1.000 56.12401  ? 1627 MET A CG    1 
ATOM   1411 S  SD    . MET A 1 211 ? 20.25200 -1.18700  -2.28200  1.000 62.86012  ? 1627 MET A SD    1 
ATOM   1412 C  CE    . MET A 1 211 ? 19.32000 -0.46800  -0.93200  1.000 46.94660  ? 1627 MET A CE    1 
ATOM   1413 N  N     . ASN A 1 212 ? 16.81600 -0.61200  -6.29300  1.000 45.04100  ? 1628 ASN A N     1 
ATOM   1414 C  CA    . ASN A 1 212 ? 16.76700 -0.99200  -7.69600  1.000 43.31014  ? 1628 ASN A CA    1 
ATOM   1415 C  C     . ASN A 1 212 ? 18.10000 -1.59500  -8.13100  1.000 41.10379  ? 1628 ASN A C     1 
ATOM   1416 O  O     . ASN A 1 212 ? 19.11600 -1.48700  -7.43800  1.000 43.78935  ? 1628 ASN A O     1 
ATOM   1417 C  CB    . ASN A 1 212 ? 16.40200 0.23100   -8.53800  1.000 42.33081  ? 1628 ASN A CB    1 
ATOM   1418 C  CG    . ASN A 1 212 ? 14.91400 0.55200   -8.47400  1.000 45.62520  ? 1628 ASN A CG    1 
ATOM   1419 O  OD1   . ASN A 1 212 ? 14.07200 -0.34700  -8.45000  1.000 44.05869  ? 1628 ASN A OD1   1 
ATOM   1420 N  ND2   . ASN A 1 212 ? 14.58900 1.83000   -8.46100  1.000 44.24062  ? 1628 ASN A ND2   1 
ATOM   1421 N  N     . HIS A 1 213 ? 18.07900 -2.26800  -9.27500  1.000 46.54411  ? 1629 HIS A N     1 
ATOM   1422 C  CA    . HIS A 1 213 ? 19.27700 -2.91600  -9.77800  1.000 45.25504  ? 1629 HIS A CA    1 
ATOM   1423 C  C     . HIS A 1 213 ? 20.07800 -1.93900  -10.63500 1.000 46.59765  ? 1629 HIS A C     1 
ATOM   1424 O  O     . HIS A 1 213 ? 19.52000 -1.03500  -11.26200 1.000 43.23803  ? 1629 HIS A O     1 
ATOM   1425 C  CB    . HIS A 1 213 ? 18.92200 -4.15600  -10.60500 1.000 45.18143  ? 1629 HIS A CB    1 
ATOM   1426 C  CG    . HIS A 1 213 ? 20.02600 -4.58200  -11.52000 1.000 44.19390  ? 1629 HIS A CG    1 
ATOM   1427 N  ND1   . HIS A 1 213 ? 21.08500 -5.35700  -11.09900 1.000 44.99370  ? 1629 HIS A ND1   1 
ATOM   1428 C  CD2   . HIS A 1 213 ? 20.27500 -4.27600  -12.81300 1.000 45.23995  ? 1629 HIS A CD2   1 
ATOM   1429 C  CE1   . HIS A 1 213 ? 21.91600 -5.54800  -12.10800 1.000 48.88888  ? 1629 HIS A CE1   1 
ATOM   1430 N  NE2   . HIS A 1 213 ? 21.45200 -4.89500  -13.15900 1.000 48.65351  ? 1629 HIS A NE2   1 
ATOM   1431 N  N     . SER A 1 214 ? 21.39900 -2.11500  -10.63700 1.000 47.12380  ? 1630 SER A N     1 
ATOM   1432 C  CA    . SER A 1 214 ? 22.27700 -1.38400  -11.53200 1.000 49.65593  ? 1630 SER A CA    1 
ATOM   1433 C  C     . SER A 1 214 ? 23.41500 -2.30400  -11.93600 1.000 52.62320  ? 1630 SER A C     1 
ATOM   1434 O  O     . SER A 1 214 ? 23.94400 -3.05700  -11.10800 1.000 46.70298  ? 1630 SER A O     1 
ATOM   1435 C  CB    . SER A 1 214 ? 22.83800 -0.09600  -10.91600 1.000 52.79087  ? 1630 SER A CB    1 
ATOM   1436 O  OG    . SER A 1 214 ? 24.02200 0.31000   -11.59000 1.000 54.31623  ? 1630 SER A OG    1 
ATOM   1437 N  N     . CYS A 1 215 ? 23.75700 -2.26900  -13.23000 1.000 53.11536  ? 1631 CYS A N     1 
ATOM   1438 C  CA    . CYS A 1 215 ? 24.92000 -3.00800  -13.69100 1.000 54.31286  ? 1631 CYS A CA    1 
ATOM   1439 C  C     . CYS A 1 215 ? 26.21800 -2.41400  -13.15500 1.000 55.70724  ? 1631 CYS A C     1 
ATOM   1440 O  O     . CYS A 1 215 ? 27.28600 -3.00500  -13.34400 1.000 57.49278  ? 1631 CYS A O     1 
ATOM   1441 C  CB    . CYS A 1 215 ? 24.91500 -3.05300  -15.23300 1.000 60.36108  ? 1631 CYS A CB    1 
ATOM   1442 S  SG    . CYS A 1 215 ? 23.37900 -3.75900  -15.90400 1.000 46.05577  ? 1631 CYS A SG    1 
ATOM   1443 N  N     . GLU A 1 216 ? 26.14400 -1.27900  -12.46300 1.000 55.38578  ? 1632 GLU A N     1 
ATOM   1444 C  CA    . GLU A 1 216 ? 27.32100 -0.57000  -11.96300 1.000 62.24092  ? 1632 GLU A CA    1 
ATOM   1445 C  C     . GLU A 1 216 ? 26.96500 0.00500   -10.59300 1.000 53.73425  ? 1632 GLU A C     1 
ATOM   1446 O  O     . GLU A 1 216 ? 26.91600 1.22400   -10.39700 1.000 58.96779  ? 1632 GLU A O     1 
ATOM   1447 C  CB    . GLU A 1 216 ? 27.74500 0.51000   -12.96200 1.000 68.40261  ? 1632 GLU A CB    1 
ATOM   1448 C  CG    . GLU A 1 216 ? 29.11200 1.13800   -12.71400 1.000 80.12689  ? 1632 GLU A CG    1 
ATOM   1449 C  CD    . GLU A 1 216 ? 29.38000 2.33300   -13.62600 1.000 88.15943  ? 1632 GLU A CD    1 
ATOM   1450 O  OE1   . GLU A 1 216 ? 28.86500 2.34900   -14.76500 1.000 85.90653  ? 1632 GLU A OE1   1 
ATOM   1451 O  OE2   . GLU A 1 216 ? 30.11400 3.25400   -13.20400 1.000 90.63276  ? 1632 GLU A OE2   1 
ATOM   1452 N  N     . PRO A 1 217 ? 26.73100 -0.86000  -9.61100  1.000 53.01048  ? 1633 PRO A N     1 
ATOM   1453 C  CA    . PRO A 1 217 ? 26.04100 -0.45200  -8.38600  1.000 54.83384  ? 1633 PRO A CA    1 
ATOM   1454 C  C     . PRO A 1 217 ? 26.95800 0.18600   -7.34600  1.000 54.72195  ? 1633 PRO A C     1 
ATOM   1455 O  O     . PRO A 1 217 ? 28.18800 0.13000   -7.42400  1.000 57.12165  ? 1633 PRO A O     1 
ATOM   1456 C  CB    . PRO A 1 217 ? 25.49600 -1.78600  -7.86800  1.000 49.89114  ? 1633 PRO A CB    1 
ATOM   1457 C  CG    . PRO A 1 217 ? 26.57500 -2.74500  -8.21200  1.000 52.03825  ? 1633 PRO A CG    1 
ATOM   1458 C  CD    . PRO A 1 217 ? 27.15900 -2.26900  -9.54300  1.000 57.53997  ? 1633 PRO A CD    1 
ATOM   1459 N  N     . ASN A 1 218 ? 26.33000 0.78900   -6.33900  1.000 53.90824  ? 1634 ASN A N     1 
ATOM   1460 C  CA    . ASN A 1 218 ? 27.08800 1.37600   -5.24200  1.000 53.56900  ? 1634 ASN A CA    1 
ATOM   1461 C  C     . ASN A 1 218 ? 26.83500 0.68300   -3.90500  1.000 53.87239  ? 1634 ASN A C     1 
ATOM   1462 O  O     . ASN A 1 218 ? 27.38400 1.12100   -2.89100  1.000 57.29273  ? 1634 ASN A O     1 
ATOM   1463 C  CB    . ASN A 1 218 ? 26.79800 2.88200   -5.13500  1.000 51.75613  ? 1634 ASN A CB    1 
ATOM   1464 C  CG    . ASN A 1 218 ? 25.31700 3.18900   -5.10900  1.000 51.66552  ? 1634 ASN A CG    1 
ATOM   1465 O  OD1   . ASN A 1 218 ? 24.49700 2.33500   -4.76600  1.000 52.81177  ? 1634 ASN A OD1   1 
ATOM   1466 N  ND2   . ASN A 1 218 ? 24.96300 4.41400   -5.47800  1.000 51.06288  ? 1634 ASN A ND2   1 
ATOM   1467 N  N     . CYS A 1 219 ? 26.03300 -0.38800  -3.88500  1.000 52.07933  ? 1635 CYS A N     1 
ATOM   1468 C  CA    . CYS A 1 219 ? 25.82000 -1.25200  -2.72500  1.000 51.02100  ? 1635 CYS A CA    1 
ATOM   1469 C  C     . CYS A 1 219 ? 26.04400 -2.72300  -3.07700  1.000 49.14926  ? 1635 CYS A C     1 
ATOM   1470 O  O     . CYS A 1 219 ? 26.03700 -3.12600  -4.24700  1.000 52.16535  ? 1635 CYS A O     1 
ATOM   1471 C  CB    . CYS A 1 219 ? 24.40700 -1.09900  -2.14700  1.000 51.73911  ? 1635 CYS A CB    1 
ATOM   1472 S  SG    . CYS A 1 219 ? 23.98800 0.58500   -1.62400  1.000 51.07428  ? 1635 CYS A SG    1 
ATOM   1473 N  N     . GLU A 1 220 ? 26.23600 -3.52700  -2.03000  1.000 50.11409  ? 1636 GLU A N     1 
ATOM   1474 C  CA    . GLU A 1 220 ? 26.32400 -4.97900  -2.13300  1.000 48.20246  ? 1636 GLU A CA    1 
ATOM   1475 C  C     . GLU A 1 220 ? 25.48400 -5.61000  -1.02800  1.000 50.11452  ? 1636 GLU A C     1 
ATOM   1476 O  O     . GLU A 1 220 ? 25.25700 -5.00300  0.02500   1.000 48.41444  ? 1636 GLU A O     1 
ATOM   1477 C  CB    . GLU A 1 220 ? 27.77800 -5.48100  -2.00700  1.000 52.07772  ? 1636 GLU A CB    1 
ATOM   1478 C  CG    . GLU A 1 220 ? 28.35400 -5.34600  -0.59400  1.000 57.04444  ? 1636 GLU A CG    1 
ATOM   1479 C  CD    . GLU A 1 220 ? 29.82300 -5.74800  -0.49200  1.000 64.44010  ? 1636 GLU A CD    1 
ATOM   1480 O  OE1   . GLU A 1 220 ? 30.38200 -6.25000  -1.49100  1.000 65.09105  ? 1636 GLU A OE1   1 
ATOM   1481 O  OE2   . GLU A 1 220 ? 30.42300 -5.55500  0.59700   1.000 67.75962  ? 1636 GLU A OE2   1 
ATOM   1482 N  N     . THR A 1 221 ? 25.02000 -6.83100  -1.26000  1.000 46.73005  ? 1637 THR A N     1 
ATOM   1483 C  CA    . THR A 1 221 ? 24.46200 -7.57700  -0.14600  1.000 47.64095  ? 1637 THR A CA    1 
ATOM   1484 C  C     . THR A 1 221 ? 25.58600 -8.18500  0.66300   1.000 49.60132  ? 1637 THR A C     1 
ATOM   1485 O  O     . THR A 1 221 ? 26.67000 -8.47300  0.14400   1.000 52.63423  ? 1637 THR A O     1 
ATOM   1486 C  CB    . THR A 1 221 ? 23.54100 -8.69800  -0.60400  1.000 50.22847  ? 1637 THR A CB    1 
ATOM   1487 O  OG1   . THR A 1 221 ? 24.32700 -9.64400  -1.33500  1.000 55.18704  ? 1637 THR A OG1   1 
ATOM   1488 C  CG2   . THR A 1 221 ? 22.41600 -8.14000  -1.44800  1.000 48.99745  ? 1637 THR A CG2   1 
ATOM   1489 N  N     . GLN A 1 222 ? 25.29700 -8.41100  1.93900   1.000 48.61427  ? 1638 GLN A N     1 
ATOM   1490 C  CA    . GLN A 1 222 ? 26.25300 -9.10000  2.83500   1.000 50.44599  ? 1638 GLN A CA    1 
ATOM   1491 C  C     . GLN A 1 222 ? 25.40900 -10.04700 3.69000   1.000 48.61775  ? 1638 GLN A C     1 
ATOM   1492 O  O     . GLN A 1 222 ? 24.36800 -9.60900  4.19300   1.000 48.31616  ? 1638 GLN A O     1 
ATOM   1493 C  CB    . GLN A 1 222 ? 27.02600 -8.09700  3.68500   1.000 50.76367  ? 1638 GLN A CB    1 
ATOM   1494 C  CG    . GLN A 1 222 ? 28.25400 -7.50200  3.01900   1.000 48.41068  ? 1638 GLN A CG    1 
ATOM   1495 C  CD    . GLN A 1 222 ? 28.97400 -6.58000  3.97100   1.000 53.98642  ? 1638 GLN A CD    1 
ATOM   1496 O  OE1   . GLN A 1 222 ? 28.82400 -6.67500  5.18600   1.000 53.79325  ? 1638 GLN A OE1   1 
ATOM   1497 N  NE2   . GLN A 1 222 ? 29.75900 -5.66800  3.42400   1.000 53.11700  ? 1638 GLN A NE2   1 
ATOM   1498 N  N     . LYS A 1 223 ? 25.81200 -11.30900 3.79500   1.000 50.11853  ? 1639 LYS A N     1 
ATOM   1499 C  CA    . LYS A 1 223 ? 25.02100 -12.31200 4.54700   1.000 49.49192  ? 1639 LYS A CA    1 
ATOM   1500 C  C     . LYS A 1 223 ? 25.51900 -12.37100 5.99000   1.000 52.91860  ? 1639 LYS A C     1 
ATOM   1501 O  O     . LYS A 1 223 ? 26.60200 -12.91400 6.21900   1.000 53.95292  ? 1639 LYS A O     1 
ATOM   1502 C  CB    . LYS A 1 223 ? 25.11100 -13.68100 3.87300   1.000 56.80681  ? 1639 LYS A CB    1 
ATOM   1503 C  CG    . LYS A 1 223 ? 24.45700 -13.78100 2.50300   1.000 67.38326  ? 1639 LYS A CG    1 
ATOM   1504 C  CD    . LYS A 1 223 ? 24.87000 -15.01900 1.73900   1.000 81.37441  ? 1639 LYS A CD    1 
ATOM   1505 C  CE    . LYS A 1 223 ? 24.31900 -16.29400 2.34100   1.000 88.69371  ? 1639 LYS A CE    1 
ATOM   1506 N  NZ    . LYS A 1 223 ? 24.92000 -17.49900 1.72500   1.000 88.45437  ? 1639 LYS A NZ    1 
ATOM   1507 N  N     . TRP A 1 224 ? 24.72100 -11.86600 6.92300   1.000 50.08302  ? 1640 TRP A N     1 
ATOM   1508 C  CA    . TRP A 1 224 ? 25.15100 -11.80200 8.33700   1.000 51.23145  ? 1640 TRP A CA    1 
ATOM   1509 C  C     . TRP A 1 224 ? 24.34200 -12.77500 9.18000   1.000 53.38514  ? 1640 TRP A C     1 
ATOM   1510 O  O     . TRP A 1 224 ? 23.19600 -13.07600 8.81500   1.000 52.27725  ? 1640 TRP A O     1 
ATOM   1511 C  CB    . TRP A 1 224 ? 24.96700 -10.37500 8.86200   1.000 44.54436  ? 1640 TRP A CB    1 
ATOM   1512 C  CG    . TRP A 1 224 ? 26.07700 -9.42400  8.51300   1.000 48.34573  ? 1640 TRP A CG    1 
ATOM   1513 C  CD1   . TRP A 1 224 ? 26.36000 -8.89200  7.29100   1.000 48.60151  ? 1640 TRP A CD1   1 
ATOM   1514 C  CD2   . TRP A 1 224 ? 27.04900 -8.87600  9.42600   1.000 47.63087  ? 1640 TRP A CD2   1 
ATOM   1515 N  NE1   . TRP A 1 224 ? 27.44700 -8.06600  7.37500   1.000 51.73569  ? 1640 TRP A NE1   1 
ATOM   1516 C  CE2   . TRP A 1 224 ? 27.88900 -8.03300  8.67000   1.000 48.68456  ? 1640 TRP A CE2   1 
ATOM   1517 C  CE3   . TRP A 1 224 ? 27.28800 -9.01800  10.79600  1.000 49.38193  ? 1640 TRP A CE3   1 
ATOM   1518 C  CZ2   . TRP A 1 224 ? 28.95100 -7.34100  9.24300   1.000 49.16152  ? 1640 TRP A CZ2   1 
ATOM   1519 C  CZ3   . TRP A 1 224 ? 28.33900 -8.33200  11.35900  1.000 46.45941  ? 1640 TRP A CZ3   1 
ATOM   1520 C  CH2   . TRP A 1 224 ? 29.15700 -7.50800  10.59200  1.000 46.65099  ? 1640 TRP A CH2   1 
ATOM   1521 N  N     . THR A 1 225 ? 24.93200 -13.27700 10.25900  1.000 51.08516  ? 1641 THR A N     1 
ATOM   1522 C  CA    . THR A 1 225 ? 24.19800 -14.11600 11.19200  1.000 55.88348  ? 1641 THR A CA    1 
ATOM   1523 C  C     . THR A 1 225 ? 23.91400 -13.31200 12.45400  1.000 52.04194  ? 1641 THR A C     1 
ATOM   1524 O  O     . THR A 1 225 ? 24.83100 -12.75600 13.07400  1.000 48.95804  ? 1641 THR A O     1 
ATOM   1525 C  CB    . THR A 1 225 ? 24.95900 -15.40000 11.53300  1.000 57.36831  ? 1641 THR A CB    1 
ATOM   1526 O  OG1   . THR A 1 225 ? 26.05700 -15.09900 12.38900  1.000 61.32464  ? 1641 THR A OG1   1 
ATOM   1527 C  CG2   . THR A 1 225 ? 25.49700 -16.03000 10.27600  1.000 57.35985  ? 1641 THR A CG2   1 
ATOM   1528 N  N     . VAL A 1 226 ? 22.64100 -13.24500 12.81900  1.000 56.87010  ? 1642 VAL A N     1 
ATOM   1529 C  CA    . VAL A 1 226 ? 22.20100 -12.60800 14.04200  1.000 59.19303  ? 1642 VAL A CA    1 
ATOM   1530 C  C     . VAL A 1 226 ? 21.44000 -13.65500 14.84300  1.000 66.11803  ? 1642 VAL A C     1 
ATOM   1531 O  O     . VAL A 1 226 ? 20.38600 -14.13300 14.40300  1.000 69.01766  ? 1642 VAL A O     1 
ATOM   1532 C  CB    . VAL A 1 226 ? 21.33600 -11.37600 13.76100  1.000 57.44493  ? 1642 VAL A CB    1 
ATOM   1533 C  CG1   . VAL A 1 226 ? 20.75800 -10.84100 15.04500  1.000 66.20417  ? 1642 VAL A CG1   1 
ATOM   1534 C  CG2   . VAL A 1 226 ? 22.16000 -10.32900 13.07000  1.000 58.68221  ? 1642 VAL A CG2   1 
ATOM   1535 N  N     . ASN A 1 227 ? 21.98000 -14.01000 16.01100  1.000 62.90920  ? 1643 ASN A N     1 
ATOM   1536 C  CA    . ASN A 1 227 ? 21.38500 -14.99200 16.92000  1.000 72.27298  ? 1643 ASN A CA    1 
ATOM   1537 C  C     . ASN A 1 227 ? 21.12000 -16.33200 16.23300  1.000 75.17367  ? 1643 ASN A C     1 
ATOM   1538 O  O     . ASN A 1 227 ? 20.08100 -16.96300 16.43300  1.000 75.27894  ? 1643 ASN A O     1 
ATOM   1539 C  CB    . ASN A 1 227 ? 20.11100 -14.44100 17.55700  1.000 80.07053  ? 1643 ASN A CB    1 
ATOM   1540 C  CG    . ASN A 1 227 ? 20.36200 -13.85600 18.93300  1.000 85.13275  ? 1643 ASN A CG    1 
ATOM   1541 O  OD1   . ASN A 1 227 ? 21.40300 -14.10400 19.55100  1.000 85.47490  ? 1643 ASN A OD1   1 
ATOM   1542 N  ND2   . ASN A 1 227 ? 19.41800 -13.06400 19.41300  1.000 90.00702  ? 1643 ASN A ND2   1 
ATOM   1543 N  N     . GLY A 1 228 ? 22.08300 -16.78500 15.43800  1.000 69.42034  ? 1644 GLY A N     1 
ATOM   1544 C  CA    . GLY A 1 228 ? 21.97100 -18.05100 14.75400  1.000 69.62300  ? 1644 GLY A CA    1 
ATOM   1545 C  C     . GLY A 1 228 ? 21.19400 -18.02100 13.46200  1.000 67.88008  ? 1644 GLY A C     1 
ATOM   1546 O  O     . GLY A 1 228 ? 21.11900 -19.05200 12.78300  1.000 66.72154  ? 1644 GLY A O     1 
ATOM   1547 N  N     . GLN A 1 229 ? 20.63300 -16.87700 13.08700  1.000 65.22040  ? 1645 GLN A N     1 
ATOM   1548 C  CA    . GLN A 1 229 ? 19.79900 -16.76800 11.90500  1.000 67.41127  ? 1645 GLN A CA    1 
ATOM   1549 C  C     . GLN A 1 229 ? 20.46800 -15.90800 10.84400  1.000 58.49429  ? 1645 GLN A C     1 
ATOM   1550 O  O     . GLN A 1 229 ? 21.08200 -14.87700 11.14300  1.000 53.84081  ? 1645 GLN A O     1 
ATOM   1551 C  CB    . GLN A 1 229 ? 18.43900 -16.17100 12.24500  1.000 71.00644  ? 1645 GLN A CB    1 
ATOM   1552 C  CG    . GLN A 1 229 ? 17.36400 -17.20300 12.48600  1.000 80.29270  ? 1645 GLN A CG    1 
ATOM   1553 C  CD    . GLN A 1 229 ? 16.38900 -16.74700 13.52900  1.000 91.17295  ? 1645 GLN A CD    1 
ATOM   1554 O  OE1   . GLN A 1 229 ? 15.88900 -15.62000 13.47400  1.000 89.09376  ? 1645 GLN A OE1   1 
ATOM   1555 N  NE2   . GLN A 1 229 ? 16.11000 -17.61300 14.49900  1.000 111.70436 ? 1645 GLN A NE2   1 
ATOM   1556 N  N     . LEU A 1 230 ? 20.32200 -16.33200 9.60300   1.000 56.47780  ? 1646 LEU A N     1 
ATOM   1557 C  CA    . LEU A 1 230 ? 20.81700 -15.55300 8.48800   1.000 54.68505  ? 1646 LEU A CA    1 
ATOM   1558 C  C     . LEU A 1 230 ? 19.97500 -14.29800 8.32900   1.000 54.84677  ? 1646 LEU A C     1 
ATOM   1559 O  O     . LEU A 1 230 ? 18.74500 -14.33000 8.43600   1.000 56.98201  ? 1646 LEU A O     1 
ATOM   1560 C  CB    . LEU A 1 230 ? 20.78800 -16.39300 7.21400   1.000 53.50818  ? 1646 LEU A CB    1 
ATOM   1561 C  CG    . LEU A 1 230 ? 20.89400 -15.65300 5.88000   1.000 51.74980  ? 1646 LEU A CG    1 
ATOM   1562 C  CD1   . LEU A 1 230 ? 22.24100 -14.95200 5.79800   1.000 47.66927  ? 1646 LEU A CD1   1 
ATOM   1563 C  CD2   . LEU A 1 230 ? 20.76600 -16.66700 4.75800   1.000 64.46338  ? 1646 LEU A CD2   1 
ATOM   1564 N  N     . ARG A 1 231 ? 20.65500 -13.17900 8.12400   1.000 51.56373  ? 1647 ARG A N     1 
ATOM   1565 C  CA    . ARG A 1 231 ? 20.01100 -11.93400 7.75200   1.000 55.01680  ? 1647 ARG A CA    1 
ATOM   1566 C  C     . ARG A 1 231 ? 20.86800 -11.28900 6.67400   1.000 49.67164  ? 1647 ARG A C     1 
ATOM   1567 O  O     . ARG A 1 231 ? 22.09900 -11.31600 6.74300   1.000 49.48971  ? 1647 ARG A O     1 
ATOM   1568 C  CB    . ARG A 1 231 ? 19.81900 -11.00500 8.96800   1.000 50.21051  ? 1647 ARG A CB    1 
ATOM   1569 C  CG    . ARG A 1 231 ? 18.84800 -11.59100 10.00400  1.000 58.13215  ? 1647 ARG A CG    1 
ATOM   1570 C  CD    . ARG A 1 231 ? 18.89700 -10.91800 11.35800  1.000 54.99230  ? 1647 ARG A CD    1 
ATOM   1571 N  NE    . ARG A 1 231 ? 18.12700 -9.68500  11.36300  1.000 54.46329  ? 1647 ARG A NE    1 
ATOM   1572 C  CZ    . ARG A 1 231 ? 17.50200 -9.17800  12.41800  1.000 58.52456  ? 1647 ARG A CZ    1 
ATOM   1573 N  NH1   . ARG A 1 231 ? 17.51700 -9.80700  13.59400  1.000 52.78168  ? 1647 ARG A NH1   1 
ATOM   1574 N  NH2   . ARG A 1 231 ? 16.84300 -8.03400  12.28700  1.000 51.98259  ? 1647 ARG A NH2   1 
ATOM   1575 N  N     . VAL A 1 232 ? 20.21800 -10.75000 5.66100   1.000 50.32216  ? 1648 VAL A N     1 
ATOM   1576 C  CA    . VAL A 1 232 ? 20.91300 -10.16900 4.52800   1.000 44.22991  ? 1648 VAL A CA    1 
ATOM   1577 C  C     . VAL A 1 232 ? 20.82400 -8.65800  4.64900   1.000 47.34852  ? 1648 VAL A C     1 
ATOM   1578 O  O     . VAL A 1 232 ? 19.73000 -8.11200  4.82700   1.000 47.40114  ? 1648 VAL A O     1 
ATOM   1579 C  CB    . VAL A 1 232 ? 20.30700 -10.65400 3.20000   1.000 49.06631  ? 1648 VAL A CB    1 
ATOM   1580 C  CG1   . VAL A 1 232 ? 21.06900 -10.06400 2.01800   1.000 44.42632  ? 1648 VAL A CG1   1 
ATOM   1581 C  CG2   . VAL A 1 232 ? 20.30500 -12.17800 3.14800   1.000 51.01255  ? 1648 VAL A CG2   1 
ATOM   1582 N  N     . GLY A 1 233 ? 21.96600 -7.98300  4.54300   1.000 43.37532  ? 1649 GLY A N     1 
ATOM   1583 C  CA    . GLY A 1 233 ? 22.01100 -6.53400  4.60600   1.000 44.68869  ? 1649 GLY A CA    1 
ATOM   1584 C  C     . GLY A 1 233 ? 22.58300 -5.93100  3.33600   1.000 47.90984  ? 1649 GLY A C     1 
ATOM   1585 O  O     . GLY A 1 233 ? 23.43100 -6.53100  2.66600   1.000 45.37586  ? 1649 GLY A O     1 
ATOM   1586 N  N     . PHE A 1 234 ? 22.12600 -4.72200  3.01900   1.000 46.86455  ? 1650 PHE A N     1 
ATOM   1587 C  CA    . PHE A 1 234 ? 22.73400 -3.89700  1.97900   1.000 47.57787  ? 1650 PHE A CA    1 
ATOM   1588 C  C     . PHE A 1 234 ? 23.78900 -2.98200  2.59600   1.000 50.79478  ? 1650 PHE A C     1 
ATOM   1589 O  O     . PHE A 1 234 ? 23.51800 -2.29500  3.58900   1.000 49.76803  ? 1650 PHE A O     1 
ATOM   1590 C  CB    . PHE A 1 234 ? 21.66600 -3.05500  1.28400   1.000 43.02692  ? 1650 PHE A CB    1 
ATOM   1591 C  CG    . PHE A 1 234 ? 20.69500 -3.84700  0.47300   1.000 45.55640  ? 1650 PHE A CG    1 
ATOM   1592 C  CD1   . PHE A 1 234 ? 21.13700 -4.70900  -0.51600  1.000 48.86994  ? 1650 PHE A CD1   1 
ATOM   1593 C  CD2   . PHE A 1 234 ? 19.33100 -3.69500  0.66700   1.000 44.82792  ? 1650 PHE A CD2   1 
ATOM   1594 C  CE1   . PHE A 1 234 ? 20.23600 -5.42400  -1.28700  1.000 44.48899  ? 1650 PHE A CE1   1 
ATOM   1595 C  CE2   . PHE A 1 234 ? 18.41700 -4.40900  -0.10000  1.000 45.83331  ? 1650 PHE A CE2   1 
ATOM   1596 C  CZ    . PHE A 1 234 ? 18.87200 -5.27500  -1.07000  1.000 45.72028  ? 1650 PHE A CZ    1 
ATOM   1597 N  N     . PHE A 1 235 ? 24.97500 -2.95500  2.00200   1.000 49.27499  ? 1651 PHE A N     1 
ATOM   1598 C  CA    . PHE A 1 235 ? 26.08300 -2.13700  2.47700   1.000 49.15790  ? 1651 PHE A CA    1 
ATOM   1599 C  C     . PHE A 1 235 ? 26.65700 -1.36400  1.30300   1.000 54.02101  ? 1651 PHE A C     1 
ATOM   1600 O  O     . PHE A 1 235 ? 26.76000 -1.91000  0.20400   1.000 51.42612  ? 1651 PHE A O     1 
ATOM   1601 C  CB    . PHE A 1 235 ? 27.20100 -3.00000  3.08000   1.000 50.77482  ? 1651 PHE A CB    1 
ATOM   1602 C  CG    . PHE A 1 235 ? 26.84200 -3.64900  4.39000   1.000 51.38407  ? 1651 PHE A CG    1 
ATOM   1603 C  CD1   . PHE A 1 235 ? 25.93800 -4.68700  4.44100   1.000 50.06083  ? 1651 PHE A CD1   1 
ATOM   1604 C  CD2   . PHE A 1 235 ? 27.43500 -3.22900  5.56500   1.000 53.12278  ? 1651 PHE A CD2   1 
ATOM   1605 C  CE1   . PHE A 1 235 ? 25.61600 -5.28200  5.64200   1.000 50.38385  ? 1651 PHE A CE1   1 
ATOM   1606 C  CE2   . PHE A 1 235 ? 27.11500 -3.81900  6.77400   1.000 51.66822  ? 1651 PHE A CE2   1 
ATOM   1607 C  CZ    . PHE A 1 235 ? 26.20800 -4.84700  6.81100   1.000 47.60194  ? 1651 PHE A CZ    1 
ATOM   1608 N  N     . THR A 1 236 ? 27.06500 -0.11600  1.53000   1.000 54.81614  ? 1652 THR A N     1 
ATOM   1609 C  CA    . THR A 1 236 ? 27.68800 0.63200   0.44800   1.000 54.28439  ? 1652 THR A CA    1 
ATOM   1610 C  C     . THR A 1 236 ? 29.04100 0.02700   0.11500   1.000 60.42932  ? 1652 THR A C     1 
ATOM   1611 O  O     . THR A 1 236 ? 29.69300 -0.58800  0.96500   1.000 58.17918  ? 1652 THR A O     1 
ATOM   1612 C  CB    . THR A 1 236 ? 27.87000 2.10300   0.81300   1.000 61.15842  ? 1652 THR A CB    1 
ATOM   1613 O  OG1   . THR A 1 236 ? 28.58600 2.20400   2.05100   1.000 63.93684  ? 1652 THR A OG1   1 
ATOM   1614 C  CG2   . THR A 1 236 ? 26.51900 2.80400   0.93300   1.000 56.96582  ? 1652 THR A CG2   1 
ATOM   1615 N  N     . THR A 1 237 ? 29.45300 0.19000   -1.14600  1.000 58.09212  ? 1653 THR A N     1 
ATOM   1616 C  CA    . THR A 1 237 ? 30.76700 -0.23900  -1.60300  1.000 58.25729  ? 1653 THR A CA    1 
ATOM   1617 C  C     . THR A 1 237 ? 31.64600 0.93200   -2.00200  1.000 61.13992  ? 1653 THR A C     1 
ATOM   1618 O  O     . THR A 1 237 ? 32.78900 0.72300   -2.42600  1.000 63.19538  ? 1653 THR A O     1 
ATOM   1619 C  CB    . THR A 1 237 ? 30.63200 -1.21500  -2.77800  1.000 54.93642  ? 1653 THR A CB    1 
ATOM   1620 O  OG1   . THR A 1 237 ? 29.84600 -0.61100  -3.81500  1.000 55.14701  ? 1653 THR A OG1   1 
ATOM   1621 C  CG2   . THR A 1 237 ? 29.96000 -2.50400  -2.31200  1.000 56.04155  ? 1653 THR A CG2   1 
ATOM   1622 N  N     . LYS A 1 238 ? 31.13800 2.15300   -1.87500  1.000 57.83619  ? 1654 LYS A N     1 
ATOM   1623 C  CA    . LYS A 1 238 ? 31.86600 3.37600   -2.17800  1.000 63.83344  ? 1654 LYS A CA    1 
ATOM   1624 C  C     . LYS A 1 238 ? 31.15200 4.50400   -1.45200  1.000 68.93964  ? 1654 LYS A C     1 
ATOM   1625 O  O     . LYS A 1 238 ? 30.05500 4.31600   -0.91500  1.000 67.89702  ? 1654 LYS A O     1 
ATOM   1626 C  CB    . LYS A 1 238 ? 31.92200 3.63800   -3.68900  1.000 66.36880  ? 1654 LYS A CB    1 
ATOM   1627 C  CG    . LYS A 1 238 ? 30.60500 4.11500   -4.28400  1.000 66.00933  ? 1654 LYS A CG    1 
ATOM   1628 C  CD    . LYS A 1 238 ? 30.67900 4.24400   -5.81000  1.000 65.56811  ? 1654 LYS A CD    1 
ATOM   1629 C  CE    . LYS A 1 238 ? 30.52100 2.88600   -6.48300  1.000 69.07820  ? 1654 LYS A CE    1 
ATOM   1630 N  NZ    . LYS A 1 238 ? 30.48900 2.98700   -7.97600  1.000 75.05260  ? 1654 LYS A NZ    1 
ATOM   1631 N  N     . LEU A 1 239 ? 31.77200 5.68800   -1.44200  1.000 71.12314  ? 1655 LEU A N     1 
ATOM   1632 C  CA    . LEU A 1 239 ? 31.09500 6.84000   -0.85700  1.000 69.82726  ? 1655 LEU A CA    1 
ATOM   1633 C  C     . LEU A 1 239 ? 29.94200 7.23100   -1.76100  1.000 66.86434  ? 1655 LEU A C     1 
ATOM   1634 O  O     . LEU A 1 239 ? 30.15000 7.62700   -2.91000  1.000 69.61669  ? 1655 LEU A O     1 
ATOM   1635 C  CB    . LEU A 1 239 ? 32.04000 8.01700   -0.64400  1.000 76.53699  ? 1655 LEU A CB    1 
ATOM   1636 C  CG    . LEU A 1 239 ? 31.49700 8.94100   0.47000   1.000 77.76608  ? 1655 LEU A CG    1 
ATOM   1637 C  CD1   . LEU A 1 239 ? 32.61200 9.62100   1.24600   1.000 77.49093  ? 1655 LEU A CD1   1 
ATOM   1638 C  CD2   . LEU A 1 239 ? 30.49400 9.98300   -0.04600  1.000 72.13909  ? 1655 LEU A CD2   1 
ATOM   1639 N  N     . VAL A 1 240 ? 28.72500 7.10600   -1.25300  1.000 69.10936  ? 1656 VAL A N     1 
ATOM   1640 C  CA    . VAL A 1 240 ? 27.52500 7.49500   -1.97700  1.000 67.60683  ? 1656 VAL A CA    1 
ATOM   1641 C  C     . VAL A 1 240 ? 27.18000 8.92900   -1.56400  1.000 67.78519  ? 1656 VAL A C     1 
ATOM   1642 O  O     . VAL A 1 240 ? 26.91300 9.16200   -0.38000  1.000 68.24272  ? 1656 VAL A O     1 
ATOM   1643 C  CB    . VAL A 1 240 ? 26.36600 6.54600   -1.67500  1.000 65.02701  ? 1656 VAL A CB    1 
ATOM   1644 C  CG1   . VAL A 1 240 ? 25.08000 7.06000   -2.28200  1.000 59.36527  ? 1656 VAL A CG1   1 
ATOM   1645 C  CG2   . VAL A 1 240 ? 26.69500 5.17100   -2.17100  1.000 61.49582  ? 1656 VAL A CG2   1 
ATOM   1646 N  N     . PRO A 1 241 ? 27.19800 9.88500   -2.48000  1.000 70.10547  ? 1657 PRO A N     1 
ATOM   1647 C  CA    . PRO A 1 241 ? 26.87800 11.26000  -2.09700  1.000 71.87236  ? 1657 PRO A CA    1 
ATOM   1648 C  C     . PRO A 1 241 ? 25.39000 11.42500  -1.85300  1.000 74.76309  ? 1657 PRO A C     1 
ATOM   1649 O  O     . PRO A 1 241 ? 24.55500 10.68900  -2.37900  1.000 70.87116  ? 1657 PRO A O     1 
ATOM   1650 C  CB    . PRO A 1 241 ? 27.34400 12.09100  -3.30400  1.000 73.72868  ? 1657 PRO A CB    1 
ATOM   1651 C  CG    . PRO A 1 241 ? 28.24100 11.18100  -4.09200  1.000 68.83319  ? 1657 PRO A CG    1 
ATOM   1652 C  CD    . PRO A 1 241 ? 27.66800 9.80000   -3.86900  1.000 71.45949  ? 1657 PRO A CD    1 
ATOM   1653 N  N     . SER A 1 242 ? 25.07500 12.42200  -1.03200  1.000 78.97149  ? 1658 SER A N     1 
ATOM   1654 C  CA    . SER A 1 242 ? 23.68900 12.74000  -0.72400  1.000 79.41628  ? 1658 SER A CA    1 
ATOM   1655 C  C     . SER A 1 242 ? 22.89500 12.96700  -2.00300  1.000 75.32981  ? 1658 SER A C     1 
ATOM   1656 O  O     . SER A 1 242 ? 23.35200 13.65800  -2.91600  1.000 86.45660  ? 1658 SER A O     1 
ATOM   1657 C  CB    . SER A 1 242 ? 23.63000 13.98000  0.16700   1.000 80.35587  ? 1658 SER A CB    1 
ATOM   1658 O  OG    . SER A 1 242 ? 22.29300 14.31400  0.48000   1.000 88.15417  ? 1658 SER A OG    1 
ATOM   1659 N  N     . GLY A 1 243 ? 21.70800 12.36900  -2.07000  1.000 68.88983  ? 1659 GLY A N     1 
ATOM   1660 C  CA    . GLY A 1 243 ? 20.83700 12.51900  -3.21400  1.000 70.43544  ? 1659 GLY A CA    1 
ATOM   1661 C  C     . GLY A 1 243 ? 20.96200 11.44100  -4.26900  1.000 64.60163  ? 1659 GLY A C     1 
ATOM   1662 O  O     . GLY A 1 243 ? 20.08300 11.34500  -5.13400  1.000 67.27262  ? 1659 GLY A O     1 
ATOM   1663 N  N     . SER A 1 244 ? 22.01300 10.62100  -4.22400  1.000 60.71568  ? 1660 SER A N     1 
ATOM   1664 C  CA    . SER A 1 244 ? 22.20100 9.57100   -5.22000  1.000 63.62149  ? 1660 SER A CA    1 
ATOM   1665 C  C     . SER A 1 244 ? 21.32800 8.36400   -4.92700  1.000 59.84867  ? 1660 SER A C     1 
ATOM   1666 O  O     . SER A 1 244 ? 21.10000 8.00200   -3.76500  1.000 54.50193  ? 1660 SER A O     1 
ATOM   1667 C  CB    . SER A 1 244 ? 23.66600 9.13500   -5.28500  1.000 63.93411  ? 1660 SER A CB    1 
ATOM   1668 O  OG    . SER A 1 244 ? 24.53400 10.24700  -5.17200  1.000 84.20633  ? 1660 SER A OG    1 
ATOM   1669 N  N     . GLU A 1 245 ? 20.86100 7.72700   -5.99600  1.000 54.35083  ? 1661 GLU A N     1 
ATOM   1670 C  CA    . GLU A 1 245 ? 20.11300 6.48900   -5.86000  1.000 51.25995  ? 1661 GLU A CA    1 
ATOM   1671 C  C     . GLU A 1 245 ? 21.01800 5.37700   -5.35400  1.000 50.38549  ? 1661 GLU A C     1 
ATOM   1672 O  O     . GLU A 1 245 ? 22.18300 5.27200   -5.74300  1.000 51.51235  ? 1661 GLU A O     1 
ATOM   1673 C  CB    . GLU A 1 245 ? 19.48300 6.07700   -7.19700  1.000 53.16565  ? 1661 GLU A CB    1 
ATOM   1674 C  CG    . GLU A 1 245 ? 18.53300 4.88200   -7.02700  1.000 47.68814  ? 1661 GLU A CG    1 
ATOM   1675 C  CD    . GLU A 1 245 ? 17.81700 4.43700   -8.31400  1.000 50.38734  ? 1661 GLU A CD    1 
ATOM   1676 O  OE1   . GLU A 1 245 ? 18.04000 5.02900   -9.39700  1.000 48.77576  ? 1661 GLU A OE1   1 
ATOM   1677 O  OE2   . GLU A 1 245 ? 17.01100 3.48200   -8.22700  1.000 47.22829  ? 1661 GLU A OE2   1 
ATOM   1678 N  N     . LEU A 1 246 ? 20.48800 4.55900   -4.45800  1.000 49.36285  ? 1662 LEU A N     1 
ATOM   1679 C  CA    . LEU A 1 246 ? 21.19000 3.38300   -3.97400  1.000 50.93330  ? 1662 LEU A CA    1 
ATOM   1680 C  C     . LEU A 1 246 ? 20.73600 2.17700   -4.78500  1.000 47.24749  ? 1662 LEU A C     1 
ATOM   1681 O  O     . LEU A 1 246 ? 19.54300 2.01600   -5.05500  1.000 47.69405  ? 1662 LEU A O     1 
ATOM   1682 C  CB    . LEU A 1 246 ? 20.92800 3.16100   -2.49000  1.000 48.50225  ? 1662 LEU A CB    1 
ATOM   1683 C  CG    . LEU A 1 246 ? 21.45000 4.33100   -1.63100  1.000 52.54104  ? 1662 LEU A CG    1 
ATOM   1684 C  CD1   . LEU A 1 246 ? 20.65100 4.50800   -0.35200  1.000 50.79808  ? 1662 LEU A CD1   1 
ATOM   1685 C  CD2   . LEU A 1 246 ? 22.92800 4.15700   -1.31700  1.000 54.04159  ? 1662 LEU A CD2   1 
ATOM   1686 N  N     . THR A 1 247 ? 21.69800 1.34300   -5.18200  1.000 45.33999  ? 1663 THR A N     1 
ATOM   1687 C  CA    . THR A 1 247 ? 21.45300 0.23300   -6.08900  1.000 47.39078  ? 1663 THR A CA    1 
ATOM   1688 C  C     . THR A 1 247 ? 22.37000 -0.92200  -5.73000  1.000 47.65715  ? 1663 THR A C     1 
ATOM   1689 O  O     . THR A 1 247 ? 23.42400 -0.73200  -5.11700  1.000 48.76750  ? 1663 THR A O     1 
ATOM   1690 C  CB    . THR A 1 247 ? 21.74500 0.64100   -7.53300  1.000 48.48223  ? 1663 THR A CB    1 
ATOM   1691 O  OG1   . THR A 1 247 ? 23.09200 1.12800   -7.59600  1.000 47.41179  ? 1663 THR A OG1   1 
ATOM   1692 C  CG2   . THR A 1 247 ? 20.78700 1.73000   -7.99500  1.000 41.77895  ? 1663 THR A CG2   1 
ATOM   1693 N  N     . PHE A 1 248 ? 21.99300 -2.12100  -6.16200  1.000 44.16547  ? 1664 PHE A N     1 
ATOM   1694 C  CA    . PHE A 1 248 ? 22.91900 -3.24200  -6.11200  1.000 45.78235  ? 1664 PHE A CA    1 
ATOM   1695 C  C     . PHE A 1 248 ? 22.73700 -4.08600  -7.36600  1.000 47.41771  ? 1664 PHE A C     1 
ATOM   1696 O  O     . PHE A 1 248 ? 21.85800 -3.83300  -8.19300  1.000 45.91226  ? 1664 PHE A O     1 
ATOM   1697 C  CB    . PHE A 1 248 ? 22.76900 -4.06500  -4.81700  1.000 46.18716  ? 1664 PHE A CB    1 
ATOM   1698 C  CG    . PHE A 1 248 ? 21.52900 -4.91900  -4.74300  1.000 46.65901  ? 1664 PHE A CG    1 
ATOM   1699 C  CD1   . PHE A 1 248 ? 20.28700 -4.35100  -4.50100  1.000 46.08638  ? 1664 PHE A CD1   1 
ATOM   1700 C  CD2   . PHE A 1 248 ? 21.61700 -6.30300  -4.85800  1.000 45.07990  ? 1664 PHE A CD2   1 
ATOM   1701 C  CE1   . PHE A 1 248 ? 19.13400 -5.14400  -4.40800  1.000 43.07334  ? 1664 PHE A CE1   1 
ATOM   1702 C  CE2   . PHE A 1 248 ? 20.47000 -7.11400  -4.75200  1.000 44.71949  ? 1664 PHE A CE2   1 
ATOM   1703 C  CZ    . PHE A 1 248 ? 19.22800 -6.52800  -4.52000  1.000 43.37549  ? 1664 PHE A CZ    1 
ATOM   1704 N  N     . ASP A 1 249 ? 23.63200 -5.05400  -7.53300  1.000 48.39998  ? 1665 ASP A N     1 
ATOM   1705 C  CA    . ASP A 1 249 ? 23.59900 -5.96800  -8.67000  1.000 46.09104  ? 1665 ASP A CA    1 
ATOM   1706 C  C     . ASP A 1 249 ? 22.72100 -7.15100  -8.28300  1.000 43.93734  ? 1665 ASP A C     1 
ATOM   1707 O  O     . ASP A 1 249 ? 23.14900 -8.03900  -7.55200  1.000 49.82342  ? 1665 ASP A O     1 
ATOM   1708 C  CB    . ASP A 1 249 ? 25.00800 -6.40800  -9.06200  1.000 51.72621  ? 1665 ASP A CB    1 
ATOM   1709 C  CG    . ASP A 1 249 ? 25.02900 -7.20000  -10.37500 1.000 54.42843  ? 1665 ASP A CG    1 
ATOM   1710 O  OD1   . ASP A 1 249 ? 23.94200 -7.54200  -10.87600 1.000 44.57476  ? 1665 ASP A OD1   1 
ATOM   1711 O  OD2   . ASP A 1 249 ? 26.12400 -7.48600  -10.90500 1.000 54.78929  ? 1665 ASP A OD2   1 
ATOM   1712 N  N     . TYR A 1 250 ? 21.48400 -7.16300  -8.78300  1.000 45.96476  ? 1666 TYR A N     1 
ATOM   1713 C  CA    . TYR A 1 250 ? 20.57000 -8.26100  -8.49600  1.000 47.16424  ? 1666 TYR A CA    1 
ATOM   1714 C  C     . TYR A 1 250 ? 21.17300 -9.62500  -8.80200  1.000 48.71256  ? 1666 TYR A C     1 
ATOM   1715 O  O     . TYR A 1 250 ? 20.77100 -10.62500 -8.19400  1.000 44.70166  ? 1666 TYR A O     1 
ATOM   1716 C  CB    . TYR A 1 250 ? 19.29000 -8.11700  -9.31600  1.000 44.40553  ? 1666 TYR A CB    1 
ATOM   1717 C  CG    . TYR A 1 250 ? 18.32600 -7.04800  -8.86100  1.000 46.84296  ? 1666 TYR A CG    1 
ATOM   1718 C  CD1   . TYR A 1 250 ? 18.66200 -6.14400  -7.85100  1.000 43.26114  ? 1666 TYR A CD1   1 
ATOM   1719 C  CD2   . TYR A 1 250 ? 17.07700 -6.93000  -9.45500  1.000 43.33394  ? 1666 TYR A CD2   1 
ATOM   1720 C  CE1   . TYR A 1 250 ? 17.76900 -5.14800  -7.45300  1.000 42.12757  ? 1666 TYR A CE1   1 
ATOM   1721 C  CE2   . TYR A 1 250 ? 16.18700 -5.94000  -9.07500  1.000 45.81332  ? 1666 TYR A CE2   1 
ATOM   1722 C  CZ    . TYR A 1 250 ? 16.53300 -5.06600  -8.05200  1.000 46.99625  ? 1666 TYR A CZ    1 
ATOM   1723 O  OH    . TYR A 1 250 ? 15.64400 -4.09800  -7.65200  1.000 42.09149  ? 1666 TYR A OH    1 
ATOM   1724 N  N     . GLN A 1 251 ? 22.10500 -9.69900  -9.75800  1.000 53.48440  ? 1667 GLN A N     1 
ATOM   1725 C  CA    . GLN A 1 251 ? 22.49900 -10.98200 -10.33500 1.000 51.43638  ? 1667 GLN A CA    1 
ATOM   1726 C  C     . GLN A 1 251 ? 21.23800 -11.77700 -10.66100 1.000 49.99330  ? 1667 GLN A C     1 
ATOM   1727 O  O     . GLN A 1 251 ? 21.07700 -12.93800 -10.29100 1.000 47.16122  ? 1667 GLN A O     1 
ATOM   1728 C  CB    . GLN A 1 251 ? 23.42200 -11.76000 -9.39200  1.000 61.85733  ? 1667 GLN A CB    1 
ATOM   1729 C  CG    . GLN A 1 251 ? 24.86400 -11.27100 -9.35900  1.000 67.14407  ? 1667 GLN A CG    1 
ATOM   1730 C  CD    . GLN A 1 251 ? 25.59700 -11.52700 -10.65700 1.000 84.58795  ? 1667 GLN A CD    1 
ATOM   1731 O  OE1   . GLN A 1 251 ? 25.38700 -12.54800 -11.31100 1.000 97.06050  ? 1667 GLN A OE1   1 
ATOM   1732 N  NE2   . GLN A 1 251 ? 26.46200 -10.59600 -11.04300 1.000 90.51761  ? 1667 GLN A NE2   1 
ATOM   1733 N  N     . PHE A 1 252 ? 20.31100 -11.09600 -11.31300 1.000 44.89399  ? 1668 PHE A N     1 
ATOM   1734 C  CA    . PHE A 1 252 ? 18.95100 -11.58700 -11.47700 1.000 51.22053  ? 1668 PHE A CA    1 
ATOM   1735 C  C     . PHE A 1 252 ? 18.90800 -12.85500 -12.32900 1.000 52.43897  ? 1668 PHE A C     1 
ATOM   1736 O  O     . PHE A 1 252 ? 19.59800 -12.96600 -13.34900 1.000 51.03004  ? 1668 PHE A O     1 
ATOM   1737 C  CB    . PHE A 1 252 ? 18.13300 -10.47600 -12.11700 1.000 49.05127  ? 1668 PHE A CB    1 
ATOM   1738 C  CG    . PHE A 1 252 ? 16.65600 -10.69700 -12.12100 1.000 50.44204  ? 1668 PHE A CG    1 
ATOM   1739 C  CD1   . PHE A 1 252 ? 15.89500 -10.41100 -10.99000 1.000 53.17258  ? 1668 PHE A CD1   1 
ATOM   1740 C  CD2   . PHE A 1 252 ? 16.01200 -11.09300 -13.28900 1.000 52.06675  ? 1668 PHE A CD2   1 
ATOM   1741 C  CE1   . PHE A 1 252 ? 14.52000 -10.57400 -11.00800 1.000 51.22002  ? 1668 PHE A CE1   1 
ATOM   1742 C  CE2   . PHE A 1 252 ? 14.63900 -11.25500 -13.32600 1.000 53.16423  ? 1668 PHE A CE2   1 
ATOM   1743 C  CZ    . PHE A 1 252 ? 13.89200 -10.99500 -12.18700 1.000 57.01096  ? 1668 PHE A CZ    1 
ATOM   1744 N  N     . GLN A 1 253 ? 18.09000 -13.81700 -11.89500 1.000 52.60347  ? 1669 GLN A N     1 
ATOM   1745 C  CA    . GLN A 1 253 ? 17.87200 -15.08100 -12.58900 1.000 55.50685  ? 1669 GLN A CA    1 
ATOM   1746 C  C     . GLN A 1 253 ? 16.43900 -15.08400 -13.10700 1.000 50.61793  ? 1669 GLN A C     1 
ATOM   1747 O  O     . GLN A 1 253 ? 15.50200 -15.31200 -12.34300 1.000 48.19701  ? 1669 GLN A O     1 
ATOM   1748 C  CB    . GLN A 1 253 ? 18.12000 -16.25700 -11.65500 1.000 55.92662  ? 1669 GLN A CB    1 
ATOM   1749 C  CG    . GLN A 1 253 ? 19.37800 -16.13100 -10.84400 1.000 60.25442  ? 1669 GLN A CG    1 
ATOM   1750 C  CD    . GLN A 1 253 ? 20.61600 -16.27100 -11.69000 1.000 68.00965  ? 1669 GLN A CD    1 
ATOM   1751 O  OE1   . GLN A 1 253 ? 20.86200 -17.32300 -12.27300 1.000 77.39498  ? 1669 GLN A OE1   1 
ATOM   1752 N  NE2   . GLN A 1 253 ? 21.40500 -15.21000 -11.76300 1.000 70.48889  ? 1669 GLN A NE2   1 
ATOM   1753 N  N     . ARG A 1 254 ? 16.26500 -14.83000 -14.40100 1.000 50.15840  ? 1670 ARG A N     1 
ATOM   1754 C  CA    . ARG A 1 254 ? 14.92500 -14.76100 -14.96500 1.000 48.90218  ? 1670 ARG A CA    1 
ATOM   1755 C  C     . ARG A 1 254 ? 14.41400 -16.16800 -15.26300 1.000 55.81611  ? 1670 ARG A C     1 
ATOM   1756 O  O     . ARG A 1 254 ? 15.12300 -16.98100 -15.86500 1.000 53.66088  ? 1670 ARG A O     1 
ATOM   1757 C  CB    . ARG A 1 254 ? 14.91500 -13.90300 -16.24300 1.000 51.86661  ? 1670 ARG A CB    1 
ATOM   1758 C  CG    . ARG A 1 254 ? 13.67600 -14.07900 -17.11200 1.000 47.13082  ? 1670 ARG A CG    1 
ATOM   1759 C  CD    . ARG A 1 254 ? 13.75300 -13.22800 -18.40100 1.000 56.17506  ? 1670 ARG A CD    1 
ATOM   1760 N  NE    . ARG A 1 254 ? 15.09200 -13.22300 -18.99500 1.000 58.83410  ? 1670 ARG A NE    1 
ATOM   1761 C  CZ    . ARG A 1 254 ? 15.48000 -14.05900 -19.94700 1.000 65.15404  ? 1670 ARG A CZ    1 
ATOM   1762 N  NH1   . ARG A 1 254 ? 14.62100 -14.94600 -20.42800 1.000 68.60709  ? 1670 ARG A NH1   1 
ATOM   1763 N  NH2   . ARG A 1 254 ? 16.71800 -14.00000 -20.43000 1.000 75.29210  ? 1670 ARG A NH2   1 
ATOM   1764 N  N     . TYR A 1 255 ? 13.19100 -16.46400 -14.81300 1.000 52.15572  ? 1671 TYR A N     1 
ATOM   1765 C  CA    . TYR A 1 255 ? 12.44700 -17.60800 -15.32800 1.000 52.99811  ? 1671 TYR A CA    1 
ATOM   1766 C  C     . TYR A 1 255 ? 11.26600 -17.19400 -16.19200 1.000 57.29693  ? 1671 TYR A C     1 
ATOM   1767 O  O     . TYR A 1 255 ? 10.65400 -18.05900 -16.81800 1.000 57.62761  ? 1671 TYR A O     1 
ATOM   1768 C  CB    . TYR A 1 255 ? 11.94900 -18.51700 -14.18100 1.000 51.24586  ? 1671 TYR A CB    1 
ATOM   1769 C  CG    . TYR A 1 255 ? 11.09900 -17.80500 -13.14800 1.000 54.41742  ? 1671 TYR A CG    1 
ATOM   1770 C  CD1   . TYR A 1 255 ? 9.78700  -17.43300 -13.43200 1.000 53.48949  ? 1671 TYR A CD1   1 
ATOM   1771 C  CD2   . TYR A 1 255 ? 11.61100 -17.49200 -11.89300 1.000 51.19272  ? 1671 TYR A CD2   1 
ATOM   1772 C  CE1   . TYR A 1 255 ? 9.00800  -16.76800 -12.49700 1.000 53.52479  ? 1671 TYR A CE1   1 
ATOM   1773 C  CE2   . TYR A 1 255 ? 10.84300 -16.82000 -10.94900 1.000 51.51363  ? 1671 TYR A CE2   1 
ATOM   1774 C  CZ    . TYR A 1 255 ? 9.53800  -16.46500 -11.25600 1.000 52.08669  ? 1671 TYR A CZ    1 
ATOM   1775 O  OH    . TYR A 1 255 ? 8.76400  -15.79100 -10.32900 1.000 50.24954  ? 1671 TYR A OH    1 
ATOM   1776 N  N     . GLY A 1 256 ? 10.92000 -15.90700 -16.23500 1.000 52.08137  ? 1672 GLY A N     1 
ATOM   1777 C  CA    . GLY A 1 256 ? 9.85800  -15.46900 -17.12200 1.000 55.58877  ? 1672 GLY A CA    1 
ATOM   1778 C  C     . GLY A 1 256 ? 10.24600 -15.60800 -18.58400 1.000 53.46317  ? 1672 GLY A C     1 
ATOM   1779 O  O     . GLY A 1 256 ? 11.42000 -15.55600 -18.94700 1.000 50.93141  ? 1672 GLY A O     1 
ATOM   1780 N  N     . LYS A 1 257 ? 9.23200  -15.80400 -19.43700 1.000 59.75344  ? 1673 LYS A N     1 
ATOM   1781 C  CA    . LYS A 1 257 ? 9.45900  -15.85000 -20.88400 1.000 62.43505  ? 1673 LYS A CA    1 
ATOM   1782 C  C     . LYS A 1 257 ? 10.03300 -14.53400 -21.41500 1.000 66.33576  ? 1673 LYS A C     1 
ATOM   1783 O  O     . LYS A 1 257 ? 10.91000 -14.54200 -22.28600 1.000 65.56462  ? 1673 LYS A O     1 
ATOM   1784 C  CB    . LYS A 1 257 ? 8.15400  -16.17600 -21.61000 1.000 63.18938  ? 1673 LYS A CB    1 
ATOM   1785 C  CG    . LYS A 1 257 ? 7.63400  -17.60000 -21.43900 1.000 71.38649  ? 1673 LYS A CG    1 
ATOM   1786 C  CD    . LYS A 1 257 ? 6.13100  -17.68600 -21.76500 1.000 78.64837  ? 1673 LYS A CD    1 
ATOM   1787 C  CE    . LYS A 1 257 ? 5.72700  -19.05500 -22.31600 1.000 80.73086  ? 1673 LYS A CE    1 
ATOM   1788 N  NZ    . LYS A 1 257 ? 4.25200  -19.28800 -22.22300 1.000 82.79201  ? 1673 LYS A NZ    1 
ATOM   1789 N  N     . GLU A 1 258 ? 9.56000  -13.39200 -20.89600 1.000 64.68961  ? 1674 GLU A N     1 
ATOM   1790 C  CA    . GLU A 1 258 ? 9.87300  -12.07300 -21.44400 1.000 63.44403  ? 1674 GLU A CA    1 
ATOM   1791 C  C     . GLU A 1 258 ? 10.87500 -11.34800 -20.56000 1.000 61.65384  ? 1674 GLU A C     1 
ATOM   1792 O  O     . GLU A 1 258 ? 10.59000 -11.07200 -19.38700 1.000 54.47709  ? 1674 GLU A O     1 
ATOM   1793 C  CB    . GLU A 1 258 ? 8.61000  -11.22600 -21.59600 1.000 66.45453  ? 1674 GLU A CB    1 
ATOM   1794 C  CG    . GLU A 1 258 ? 7.75700  -11.61800 -22.79300 1.000 86.12761  ? 1674 GLU A CG    1 
ATOM   1795 C  CD    . GLU A 1 258 ? 6.28500  -11.66800 -22.45600 1.000 102.97174 ? 1674 GLU A CD    1 
ATOM   1796 O  OE1   . GLU A 1 258 ? 5.73200  -10.61700 -22.06100 1.000 105.68522 ? 1674 GLU A OE1   1 
ATOM   1797 O  OE2   . GLU A 1 258 ? 5.68400  -12.75900 -22.57700 1.000 109.98837 ? 1674 GLU A OE2   1 
ATOM   1798 N  N     . ALA A 1 259 ? 12.02800 -11.00800 -21.13000 1.000 58.44386  ? 1675 ALA A N     1 
ATOM   1799 C  CA    . ALA A 1 259 ? 13.06600 -10.35000 -20.35000 1.000 55.13585  ? 1675 ALA A CA    1 
ATOM   1800 C  C     . ALA A 1 259 ? 12.71600 -8.89300  -20.10200 1.000 54.30901  ? 1675 ALA A C     1 
ATOM   1801 O  O     . ALA A 1 259 ? 11.93000 -8.28000  -20.83100 1.000 51.76429  ? 1675 ALA A O     1 
ATOM   1802 C  CB    . ALA A 1 259 ? 14.41700 -10.44100 -21.05100 1.000 52.76469  ? 1675 ALA A CB    1 
ATOM   1803 N  N     . GLN A 1 260 ? 13.30900 -8.34500  -19.04500 1.000 52.47092  ? 1676 GLN A N     1 
ATOM   1804 C  CA    . GLN A 1 260 ? 13.10900 -6.95800  -18.64800 1.000 49.20845  ? 1676 GLN A CA    1 
ATOM   1805 C  C     . GLN A 1 260 ? 14.35100 -6.15500  -19.02000 1.000 50.74922  ? 1676 GLN A C     1 
ATOM   1806 O  O     . GLN A 1 260 ? 15.44100 -6.43600  -18.51200 1.000 49.27910  ? 1676 GLN A O     1 
ATOM   1807 C  CB    . GLN A 1 260 ? 12.84200 -6.85200  -17.14000 1.000 50.65426  ? 1676 GLN A CB    1 
ATOM   1808 C  CG    . GLN A 1 260 ? 12.75000 -5.42600  -16.64400 1.000 49.51964  ? 1676 GLN A CG    1 
ATOM   1809 C  CD    . GLN A 1 260 ? 11.69800 -4.61700  -17.39100 1.000 47.68523  ? 1676 GLN A CD    1 
ATOM   1810 O  OE1   . GLN A 1 260 ? 10.49800 -4.87800  -17.28500 1.000 55.98452  ? 1676 GLN A OE1   1 
ATOM   1811 N  NE2   . GLN A 1 260 ? 12.14900 -3.63300  -18.15500 1.000 50.65172  ? 1676 GLN A NE2   1 
ATOM   1812 N  N     . LYS A 1 261 ? 14.18900 -5.16900  -19.90500 1.000 42.92760  ? 1677 LYS A N     1 
ATOM   1813 C  CA    . LYS A 1 261 ? 15.30300 -4.30500  -20.26800 1.000 47.67238  ? 1677 LYS A CA    1 
ATOM   1814 C  C     . LYS A 1 261 ? 15.77400 -3.51900  -19.05700 1.000 50.72258  ? 1677 LYS A C     1 
ATOM   1815 O  O     . LYS A 1 261 ? 14.96800 -3.02300  -18.26000 1.000 43.26594  ? 1677 LYS A O     1 
ATOM   1816 C  CB    . LYS A 1 261 ? 14.88400 -3.33600  -21.38300 1.000 49.28077  ? 1677 LYS A CB    1 
ATOM   1817 C  CG    . LYS A 1 261 ? 14.33500 -4.01800  -22.62800 1.000 51.85596  ? 1677 LYS A CG    1 
ATOM   1818 C  CD    . LYS A 1 261 ? 14.19000 -3.04200  -23.80400 1.000 57.81107  ? 1677 LYS A CD    1 
ATOM   1819 C  CE    . LYS A 1 261 ? 13.64900 -3.77300  -25.04700 1.000 56.37394  ? 1677 LYS A CE    1 
ATOM   1820 N  NZ    . LYS A 1 261 ? 14.05100 -3.03500  -26.27600 1.000 54.23082  ? 1677 LYS A NZ    1 
ATOM   1821 N  N     . CYS A 1 262 ? 17.08600 -3.36800  -18.93200 1.000 49.41211  ? 1678 CYS A N     1 
ATOM   1822 C  CA    . CYS A 1 262 ? 17.66400 -2.70500  -17.76700 1.000 46.67675  ? 1678 CYS A CA    1 
ATOM   1823 C  C     . CYS A 1 262 ? 17.83900 -1.21100  -18.03000 1.000 48.25596  ? 1678 CYS A C     1 
ATOM   1824 O  O     . CYS A 1 262 ? 18.54100 -0.82400  -18.97000 1.000 49.48389  ? 1678 CYS A O     1 
ATOM   1825 C  CB    . CYS A 1 262 ? 18.99800 -3.35400  -17.41600 1.000 52.63675  ? 1678 CYS A CB    1 
ATOM   1826 S  SG    . CYS A 1 262 ? 19.92000 -2.48500  -16.13900 1.000 46.97087  ? 1678 CYS A SG    1 
ATOM   1827 N  N     . PHE A 1 263 ? 17.22200 -0.36700  -17.19500 1.000 47.41723  ? 1679 PHE A N     1 
ATOM   1828 C  CA    . PHE A 1 263 ? 17.36700 1.07800   -17.34600 1.000 45.71971  ? 1679 PHE A CA    1 
ATOM   1829 C  C     . PHE A 1 263 ? 18.36100 1.67100   -16.35200 1.000 48.68727  ? 1679 PHE A C     1 
ATOM   1830 O  O     . PHE A 1 263 ? 18.21500 2.83500   -15.96400 1.000 47.93356  ? 1679 PHE A O     1 
ATOM   1831 C  CB    . PHE A 1 263 ? 16.02100 1.79000   -17.21100 1.000 42.51653  ? 1679 PHE A CB    1 
ATOM   1832 C  CG    . PHE A 1 263 ? 14.93100 1.20900   -18.05100 1.000 45.55765  ? 1679 PHE A CG    1 
ATOM   1833 C  CD1   . PHE A 1 263 ? 15.04400 1.16400   -19.44200 1.000 52.48171  ? 1679 PHE A CD1   1 
ATOM   1834 C  CD2   . PHE A 1 263 ? 13.77900 0.70900   -17.45900 1.000 42.02413  ? 1679 PHE A CD2   1 
ATOM   1835 C  CE1   . PHE A 1 263 ? 14.02400 0.62200   -20.22600 1.000 52.40515  ? 1679 PHE A CE1   1 
ATOM   1836 C  CE2   . PHE A 1 263 ? 12.75100 0.16500   -18.23100 1.000 47.64176  ? 1679 PHE A CE2   1 
ATOM   1837 C  CZ    . PHE A 1 263 ? 12.88000 0.12300   -19.63700 1.000 48.01510  ? 1679 PHE A CZ    1 
ATOM   1838 N  N     . CYS A 1 264 ? 19.38400 0.90800   -15.94100 1.000 50.16678  ? 1680 CYS A N     1 
ATOM   1839 C  CA    . CYS A 1 264 ? 20.32500 1.45100   -14.95900 1.000 49.13970  ? 1680 CYS A CA    1 
ATOM   1840 C  C     . CYS A 1 264 ? 21.11200 2.61100   -15.54600 1.000 53.84745  ? 1680 CYS A C     1 
ATOM   1841 O  O     . CYS A 1 264 ? 21.55600 3.49400   -14.80900 1.000 49.75584  ? 1680 CYS A O     1 
ATOM   1842 C  CB    . CYS A 1 264 ? 21.28100 0.36100   -14.44400 1.000 51.51214  ? 1680 CYS A CB    1 
ATOM   1843 S  SG    . CYS A 1 264 ? 22.56400 -0.12500  -15.67100 1.000 50.87673  ? 1680 CYS A SG    1 
ATOM   1844 N  N     . GLY A 1 265 ? 21.29100 2.62800   -16.86200 1.000 56.78750  ? 1681 GLY A N     1 
ATOM   1845 C  CA    . GLY A 1 265 ? 21.96300 3.73200   -17.50300 1.000 56.13873  ? 1681 GLY A CA    1 
ATOM   1846 C  C     . GLY A 1 265 ? 23.46300 3.64800   -17.45600 1.000 58.55929  ? 1681 GLY A C     1 
ATOM   1847 O  O     . GLY A 1 265 ? 24.13700 4.59500   -17.87800 1.000 63.90799  ? 1681 GLY A O     1 
ATOM   1848 N  N     . SER A 1 266 ? 24.00700 2.54400   -16.95600 1.000 58.67226  ? 1682 SER A N     1 
ATOM   1849 C  CA    . SER A 1 266 ? 25.45100 2.38500   -16.91300 1.000 64.58604  ? 1682 SER A CA    1 
ATOM   1850 C  C     . SER A 1 266 ? 26.00700 2.21700   -18.32200 1.000 65.79201  ? 1682 SER A C     1 
ATOM   1851 O  O     . SER A 1 266 ? 25.38700 1.58300   -19.18100 1.000 63.36087  ? 1682 SER A O     1 
ATOM   1852 C  CB    . SER A 1 266 ? 25.81100 1.18200   -16.04300 1.000 62.24491  ? 1682 SER A CB    1 
ATOM   1853 O  OG    . SER A 1 266 ? 27.15400 0.79800   -16.24200 1.000 75.12629  ? 1682 SER A OG    1 
ATOM   1854 N  N     . ALA A 1 267 ? 27.17400 2.81400   -18.56800 1.000 68.56142  ? 1683 ALA A N     1 
ATOM   1855 C  CA    . ALA A 1 267 ? 27.83500 2.64000   -19.85400 1.000 68.97297  ? 1683 ALA A CA    1 
ATOM   1856 C  C     . ALA A 1 267 ? 28.30000 1.20900   -20.06300 1.000 74.62660  ? 1683 ALA A C     1 
ATOM   1857 O  O     . ALA A 1 267 ? 28.61600 0.83600   -21.19800 1.000 76.26725  ? 1683 ALA A O     1 
ATOM   1858 C  CB    . ALA A 1 267 ? 29.01700 3.60100   -19.98400 1.000 64.92408  ? 1683 ALA A CB    1 
ATOM   1859 N  N     . ASN A 1 268 ? 28.34000 0.39900   -19.00200 1.000 70.61605  ? 1684 ASN A N     1 
ATOM   1860 C  CA    . ASN A 1 268 ? 28.57800 -1.03500  -19.11500 1.000 74.23924  ? 1684 ASN A CA    1 
ATOM   1861 C  C     . ASN A 1 268 ? 27.32800 -1.84200  -18.77000 1.000 65.19333  ? 1684 ASN A C     1 
ATOM   1862 O  O     . ASN A 1 268 ? 27.42000 -2.93600  -18.20500 1.000 63.84252  ? 1684 ASN A O     1 
ATOM   1863 C  CB    . ASN A 1 268 ? 29.75200 -1.45700  -18.23300 1.000 88.95427  ? 1684 ASN A CB    1 
ATOM   1864 C  CG    . ASN A 1 268 ? 29.62300 -0.95600  -16.80600 1.000 101.86371 ? 1684 ASN A CG    1 
ATOM   1865 O  OD1   . ASN A 1 268 ? 29.81300 0.22800   -16.53300 1.000 110.46737 ? 1684 ASN A OD1   1 
ATOM   1866 N  ND2   . ASN A 1 268 ? 29.30300 -1.86200  -15.88400 1.000 102.64538 ? 1684 ASN A ND2   1 
ATOM   1867 N  N     . CYS A 1 269 ? 26.15600 -1.30600  -19.09800 1.000 62.66575  ? 1685 CYS A N     1 
ATOM   1868 C  CA    . CYS A 1 269 ? 24.90700 -1.98100  -18.78000 1.000 57.95975  ? 1685 CYS A CA    1 
ATOM   1869 C  C     . CYS A 1 269 ? 24.78300 -3.27700  -19.56400 1.000 59.68431  ? 1685 CYS A C     1 
ATOM   1870 O  O     . CYS A 1 269 ? 25.07800 -3.32900  -20.76100 1.000 60.37479  ? 1685 CYS A O     1 
ATOM   1871 C  CB    . CYS A 1 269 ? 23.71900 -1.06800  -19.08200 1.000 53.59264  ? 1685 CYS A CB    1 
ATOM   1872 S  SG    . CYS A 1 269 ? 22.09700 -1.89500  -19.00700 1.000 47.27387  ? 1685 CYS A SG    1 
ATOM   1873 N  N     . ARG A 1 270 ? 24.33000 -4.32600  -18.88400 1.000 63.66965  ? 1686 ARG A N     1 
ATOM   1874 C  CA    . ARG A 1 270 ? 24.23200 -5.64600  -19.49500 1.000 59.13998  ? 1686 ARG A CA    1 
ATOM   1875 C  C     . ARG A 1 270 ? 22.99600 -5.81100  -20.37000 1.000 54.80160  ? 1686 ARG A C     1 
ATOM   1876 O  O     . ARG A 1 270 ? 22.80200 -6.89800  -20.92800 1.000 57.03561  ? 1686 ARG A O     1 
ATOM   1877 C  CB    . ARG A 1 270 ? 24.23200 -6.73300  -18.40600 1.000 58.82434  ? 1686 ARG A CB    1 
ATOM   1878 C  CG    . ARG A 1 270 ? 25.43300 -6.68100  -17.48100 1.000 60.63771  ? 1686 ARG A CG    1 
ATOM   1879 C  CD    . ARG A 1 270 ? 25.59000 -7.96800  -16.68500 1.000 56.29378  ? 1686 ARG A CD    1 
ATOM   1880 N  NE    . ARG A 1 270 ? 24.55900 -8.12000  -15.66100 1.000 55.66255  ? 1686 ARG A NE    1 
ATOM   1881 C  CZ    . ARG A 1 270 ? 24.74500 -7.82500  -14.37700 1.000 56.73026  ? 1686 ARG A CZ    1 
ATOM   1882 N  NH1   . ARG A 1 270 ? 25.91600 -7.33700  -13.98000 1.000 52.47829  ? 1686 ARG A NH1   1 
ATOM   1883 N  NH2   . ARG A 1 270 ? 23.76100 -8.00400  -13.49500 1.000 48.74845  ? 1686 ARG A NH2   1 
ATOM   1884 N  N     . GLY A 1 271 ? 22.14400 -4.78800  -20.47100 1.000 55.64217  ? 1687 GLY A N     1 
ATOM   1885 C  CA    . GLY A 1 271 ? 20.98100 -4.82500  -21.34700 1.000 58.84310  ? 1687 GLY A CA    1 
ATOM   1886 C  C     . GLY A 1 271 ? 19.65900 -5.24500  -20.72500 1.000 51.75507  ? 1687 GLY A C     1 
ATOM   1887 O  O     . GLY A 1 271 ? 18.66900 -4.51200  -20.80300 1.000 52.71571  ? 1687 GLY A O     1 
ATOM   1888 N  N     . TYR A 1 272 ? 19.61500 -6.43400  -20.13200 1.000 47.90982  ? 1688 TYR A N     1 
ATOM   1889 C  CA    . TYR A 1 272 ? 18.41000 -6.94700  -19.49500 1.000 50.66633  ? 1688 TYR A CA    1 
ATOM   1890 C  C     . TYR A 1 272 ? 18.74200 -7.35700  -18.06400 1.000 53.27639  ? 1688 TYR A C     1 
ATOM   1891 O  O     . TYR A 1 272 ? 19.89000 -7.67300  -17.75300 1.000 50.73797  ? 1688 TYR A O     1 
ATOM   1892 C  CB    . TYR A 1 272 ? 17.85200 -8.13800  -20.26100 1.000 54.87987  ? 1688 TYR A CB    1 
ATOM   1893 C  CG    . TYR A 1 272 ? 17.49700 -7.85700  -21.70900 1.000 54.32786  ? 1688 TYR A CG    1 
ATOM   1894 C  CD1   . TYR A 1 272 ? 18.44500 -7.94400  -22.70900 1.000 58.23730  ? 1688 TYR A CD1   1 
ATOM   1895 C  CD2   . TYR A 1 272 ? 16.20000 -7.52100  -22.06800 1.000 52.50699  ? 1688 TYR A CD2   1 
ATOM   1896 C  CE1   . TYR A 1 272 ? 18.11100 -7.69900  -24.03800 1.000 62.31148  ? 1688 TYR A CE1   1 
ATOM   1897 C  CE2   . TYR A 1 272 ? 15.85200 -7.27500  -23.38700 1.000 57.92667  ? 1688 TYR A CE2   1 
ATOM   1898 C  CZ    . TYR A 1 272 ? 16.80700 -7.36100  -24.36600 1.000 61.08513  ? 1688 TYR A CZ    1 
ATOM   1899 O  OH    . TYR A 1 272 ? 16.44200 -7.11300  -25.67700 1.000 69.50892  ? 1688 TYR A OH    1 
ATOM   1900 N  N     . LEU A 1 273 ? 17.73400 -7.34900  -17.18900 1.000 52.80962  ? 1689 LEU A N     1 
ATOM   1901 C  CA    . LEU A 1 273 ? 17.98500 -7.67600  -15.78000 1.000 48.64786  ? 1689 LEU A CA    1 
ATOM   1902 C  C     . LEU A 1 273 ? 18.58400 -9.06100  -15.63400 1.000 51.80430  ? 1689 LEU A C     1 
ATOM   1903 O  O     . LEU A 1 273 ? 19.50500 -9.26700  -14.83100 1.000 51.63423  ? 1689 LEU A O     1 
ATOM   1904 C  CB    . LEU A 1 273 ? 16.69500 -7.59300  -14.97100 1.000 48.22273  ? 1689 LEU A CB    1 
ATOM   1905 C  CG    . LEU A 1 273 ? 16.13200 -6.20000  -14.71500 1.000 45.96522  ? 1689 LEU A CG    1 
ATOM   1906 C  CD1   . LEU A 1 273 ? 15.02300 -6.30100  -13.70800 1.000 47.64053  ? 1689 LEU A CD1   1 
ATOM   1907 C  CD2   . LEU A 1 273 ? 17.24400 -5.26600  -14.25400 1.000 45.88077  ? 1689 LEU A CD2   1 
ATOM   1908 N  N     . GLY A 1 274 ? 18.08100 -10.01800 -16.41200 1.000 51.34203  ? 1690 GLY A N     1 
ATOM   1909 C  CA    . GLY A 1 274 ? 18.43900 -11.40800 -16.27200 1.000 55.25490  ? 1690 GLY A CA    1 
ATOM   1910 C  C     . GLY A 1 274 ? 19.57500 -11.90700 -17.12500 1.000 55.03416  ? 1690 GLY A C     1 
ATOM   1911 O  O     . GLY A 1 274 ? 19.95300 -13.07700 -17.00100 1.000 59.10858  ? 1690 GLY A O     1 
ATOM   1912 N  N     . GLY A 1 275 ? 20.14800 -11.07500 -17.97900 1.000 56.37784  ? 1691 GLY A N     1 
ATOM   1913 C  CA    . GLY A 1 275 ? 21.14600 -11.56600 -18.90900 1.000 70.09944  ? 1691 GLY A CA    1 
ATOM   1914 C  C     . GLY A 1 275 ? 20.52900 -12.29200 -20.09200 1.000 74.58438  ? 1691 GLY A C     1 
ATOM   1915 O  O     . GLY A 1 275 ? 19.33800 -12.17500 -20.39200 1.000 72.56546  ? 1691 GLY A O     1 
ATOM   1916 N  N     . GLU A 1 276 ? 21.36900 -13.08200 -20.76200 1.000 82.58155  ? 1692 GLU A N     1 
ATOM   1917 C  CA    . GLU A 1 276 ? 20.98800 -13.61700 -22.06800 1.000 87.88730  ? 1692 GLU A CA    1 
ATOM   1918 C  C     . GLU A 1 276 ? 20.07600 -14.83500 -21.97500 1.000 85.52582  ? 1692 GLU A C     1 
ATOM   1919 O  O     . GLU A 1 276 ? 19.30900 -15.09100 -22.90800 1.000 86.43768  ? 1692 GLU A O     1 
ATOM   1920 C  CB    . GLU A 1 276 ? 22.23300 -13.98100 -22.89200 1.000 92.42643  ? 1692 GLU A CB    1 
ATOM   1921 C  CG    . GLU A 1 276 ? 23.15100 -12.80200 -23.24600 1.000 98.20256  ? 1692 GLU A CG    1 
ATOM   1922 C  CD    . GLU A 1 276 ? 22.70300 -12.03400 -24.48500 1.000 100.67504 ? 1692 GLU A CD    1 
ATOM   1923 O  OE1   . GLU A 1 276 ? 22.88300 -12.54900 -25.61900 1.000 98.61280  ? 1692 GLU A OE1   1 
ATOM   1924 O  OE2   . GLU A 1 276 ? 22.17300 -10.90900 -24.31400 1.000 99.13398  ? 1692 GLU A OE2   1 
ATOM   1925 N  N     . ASN A 1 277 ? 20.13200 -15.59700 -20.88800 1.000 83.07337  ? 1693 ASN A N     1 
ATOM   1926 C  CA    . ASN A 1 277 ? 19.48100 -16.89800 -20.87900 1.000 81.38904  ? 1693 ASN A CA    1 
ATOM   1927 C  C     . ASN A 1 277 ? 18.53300 -17.05100 -19.69800 1.000 76.61477  ? 1693 ASN A C     1 
ATOM   1928 O  O     . ASN A 1 277 ? 18.77800 -16.52900 -18.60600 1.000 73.64085  ? 1693 ASN A O     1 
ATOM   1929 C  CB    . ASN A 1 277 ? 20.52300 -18.01800 -20.89300 1.000 87.89382  ? 1693 ASN A CB    1 
ATOM   1930 C  CG    . ASN A 1 277 ? 21.06900 -18.27400 -22.30000 1.000 98.18336  ? 1693 ASN A CG    1 
ATOM   1931 O  OD1   . ASN A 1 277 ? 20.40000 -17.98500 -23.29900 1.000 94.80570  ? 1693 ASN A OD1   1 
ATOM   1932 N  ND2   . ASN A 1 277 ? 22.28500 -18.80500 -22.38200 1.000 104.63246 ? 1693 ASN A ND2   1 
ATOM   1933 N  N     . ARG A 1 278 ? 17.43600 -17.75800 -19.95400 1.000 70.37473  ? 1694 ARG A N     1 
ATOM   1934 C  CA    . ARG A 1 278 ? 16.39800 -18.03400 -18.97700 1.000 67.19991  ? 1694 ARG A CA    1 
ATOM   1935 C  C     . ARG A 1 278 ? 16.75400 -19.28600 -18.18800 1.000 65.47889  ? 1694 ARG A C     1 
ATOM   1936 O  O     . ARG A 1 278 ? 17.27400 -20.25300 -18.74800 1.000 70.00199  ? 1694 ARG A O     1 
ATOM   1937 C  CB    . ARG A 1 278 ? 15.05500 -18.22500 -19.68900 1.000 62.77259  ? 1694 ARG A CB    1 
ATOM   1938 C  CG    . ARG A 1 278 ? 13.95300 -18.77100 -18.79900 1.000 65.89097  ? 1694 ARG A CG    1 
ATOM   1939 C  CD    . ARG A 1 278 ? 12.58900 -18.67100 -19.45400 1.000 64.01847  ? 1694 ARG A CD    1 
ATOM   1940 N  NE    . ARG A 1 278 ? 12.51500 -19.51000 -20.62700 1.000 78.34143  ? 1694 ARG A NE    1 
ATOM   1941 C  CZ    . ARG A 1 278 ? 11.84200 -20.65400 -20.69100 1.000 87.53563  ? 1694 ARG A CZ    1 
ATOM   1942 N  NH1   . ARG A 1 278 ? 11.17000 -21.09500 -19.63700 1.000 85.51976  ? 1694 ARG A NH1   1 
ATOM   1943 N  NH2   . ARG A 1 278 ? 11.84200 -21.35700 -21.81700 1.000 91.23718  ? 1694 ARG A NH2   1 
ATOM   1944 N  N     . VAL A 1 279 ? 16.47200 -19.27000 -16.88400 1.000 59.58232  ? 1695 VAL A N     1 
ATOM   1945 C  CA    . VAL A 1 279 ? 16.67400 -20.44500 -16.03600 1.000 56.41496  ? 1695 VAL A CA    1 
ATOM   1946 C  C     . VAL A 1 279 ? 15.32000 -21.05300 -15.67600 1.000 58.67061  ? 1695 VAL A C     1 
ATOM   1947 O  O     . VAL A 1 279 ? 14.28100 -20.38100 -15.71100 1.000 58.43803  ? 1695 VAL A O     1 
ATOM   1948 C  CB    . VAL A 1 279 ? 17.48000 -20.09900 -14.76900 1.000 61.07592  ? 1695 VAL A CB    1 
ATOM   1949 C  CG1   . VAL A 1 279 ? 18.81900 -19.50400 -15.15900 1.000 58.20084  ? 1695 VAL A CG1   1 
ATOM   1950 C  CG2   . VAL A 1 279 ? 16.69600 -19.12700 -13.86100 1.000 57.05801  ? 1695 VAL A CG2   1 
ATOM   1951 N  N     . SER A 1 280 ? 15.32800 -22.34400 -15.35100 1.000 54.48102  ? 1696 SER A N     1 
ATOM   1952 C  CA    . SER A 1 280 ? 14.11700 -22.98400 -14.86600 1.000 59.44650  ? 1696 SER A CA    1 
ATOM   1953 C  C     . SER A 1 280 ? 13.66800 -22.34300 -13.54800 1.000 62.42136  ? 1696 SER A C     1 
ATOM   1954 O  O     . SER A 1 280 ? 14.37700 -21.54600 -12.93700 1.000 60.10086  ? 1696 SER A O     1 
ATOM   1955 C  CB    . SER A 1 280 ? 14.34300 -24.47700 -14.67500 1.000 63.86153  ? 1696 SER A CB    1 
ATOM   1956 O  OG    . SER A 1 280 ? 14.90000 -24.72300 -13.39700 1.000 68.32548  ? 1696 SER A OG    1 
ATOM   1957 N  N     . ILE A 1 281 ? 12.45300 -22.69800 -13.12500 1.000 61.52203  ? 1697 ILE A N     1 
ATOM   1958 C  CA    . ILE A 1 281 ? 11.88700 -22.14900 -11.89500 1.000 66.98584  ? 1697 ILE A CA    1 
ATOM   1959 C  C     . ILE A 1 281 ? 12.59000 -22.73800 -10.67800 1.000 67.73477  ? 1697 ILE A C     1 
ATOM   1960 O  O     . ILE A 1 281 ? 12.81500 -22.05200 -9.67600  1.000 66.18635  ? 1697 ILE A O     1 
ATOM   1961 C  CB    . ILE A 1 281 ? 10.36600 -22.40500 -11.85700 1.000 65.74096  ? 1697 ILE A CB    1 
ATOM   1962 C  CG1   . ILE A 1 281 ? 9.63300  -21.45100 -12.80200 1.000 61.62748  ? 1697 ILE A CG1   1 
ATOM   1963 C  CG2   . ILE A 1 281 ? 9.80800  -22.25900 -10.44600 1.000 62.26949  ? 1697 ILE A CG2   1 
ATOM   1964 C  CD1   . ILE A 1 281 ? 8.12300  -21.63400 -12.78700 1.000 61.64228  ? 1697 ILE A CD1   1 
ATOM   1965 N  N     . ARG A 1 282 ? 12.95300 -24.01500 -10.74500 1.000 68.14381  ? 1698 ARG A N     1 
ATOM   1966 C  CA    . ARG A 1 282 ? 13.59700 -24.64000 -9.60200  1.000 72.69071  ? 1698 ARG A CA    1 
ATOM   1967 C  C     . ARG A 1 282 ? 15.03300 -24.15300 -9.44200  1.000 73.03657  ? 1698 ARG A C     1 
ATOM   1968 O  O     . ARG A 1 282 ? 15.50100 -23.95900 -8.31500  1.000 76.09904  ? 1698 ARG A O     1 
ATOM   1969 C  CB    . ARG A 1 282 ? 13.53300 -26.15600 -9.73800  1.000 82.09339  ? 1698 ARG A CB    1 
ATOM   1970 C  CG    . ARG A 1 282 ? 14.33500 -26.71700 -10.87900 1.000 86.74869  ? 1698 ARG A CG    1 
ATOM   1971 C  CD    . ARG A 1 282 ? 15.20700 -27.84700 -10.38900 1.000 98.85996  ? 1698 ARG A CD    1 
ATOM   1972 N  NE    . ARG A 1 282 ? 14.52600 -28.64200 -9.37200  1.000 108.98491 ? 1698 ARG A NE    1 
ATOM   1973 C  CZ    . ARG A 1 282 ? 15.14600 -29.46000 -8.52800  1.000 118.66572 ? 1698 ARG A CZ    1 
ATOM   1974 N  NH1   . ARG A 1 282 ? 16.46400 -29.59200 -8.58300  1.000 122.73989 ? 1698 ARG A NH1   1 
ATOM   1975 N  NH2   . ARG A 1 282 ? 14.45300 -30.14800 -7.63100  1.000 120.53437 ? 1698 ARG A NH2   1 
ATOM   1976 N  N     . ALA A 1 283 ? 15.74600 -23.92500 -10.55200 1.000 69.62300  ? 1699 ALA A N     1 
ATOM   1977 C  CA    . ALA A 1 283 ? 17.09900 -23.38400 -10.44600 1.000 69.65325  ? 1699 ALA A CA    1 
ATOM   1978 C  C     . ALA A 1 283 ? 17.07500 -21.94100 -9.97000  1.000 67.56519  ? 1699 ALA A C     1 
ATOM   1979 O  O     . ALA A 1 283 ? 17.96000 -21.50900 -9.22400  1.000 65.51593  ? 1699 ALA A O     1 
ATOM   1980 C  CB    . ALA A 1 283 ? 17.82600 -23.49000 -11.78200 1.000 62.48004  ? 1699 ALA A CB    1 
ATOM   1981 N  N     . ALA A 1 284 ? 16.07600 -21.17500 -10.39900 1.000 65.35405  ? 1700 ALA A N     1 
ATOM   1982 C  CA    . ALA A 1 284 ? 15.93500 -19.81800 -9.89200  1.000 66.85193  ? 1700 ALA A CA    1 
ATOM   1983 C  C     . ALA A 1 284 ? 15.76000 -19.82200 -8.38200  1.000 64.99895  ? 1700 ALA A C     1 
ATOM   1984 O  O     . ALA A 1 284 ? 16.38900 -19.02700 -7.66700  1.000 65.77673  ? 1700 ALA A O     1 
ATOM   1985 C  CB    . ALA A 1 284 ? 14.75400 -19.13000 -10.57900 1.000 58.79934  ? 1700 ALA A CB    1 
ATOM   1986 N  N     . GLY A 1 285 ? 14.92300 -20.72700 -7.87700  1.000 66.09310  ? 1701 GLY A N     1 
ATOM   1987 C  CA    . GLY A 1 285 ? 14.69300 -20.91600 -6.46400  1.000 66.18941  ? 1701 GLY A CA    1 
ATOM   1988 C  C     . GLY A 1 285 ? 15.81500 -21.59700 -5.71700  1.000 75.77900  ? 1701 GLY A C     1 
ATOM   1989 O  O     . GLY A 1 285 ? 15.66800 -21.87800 -4.52500  1.000 77.26076  ? 1701 GLY A O     1 
ATOM   1990 N  N     . GLY A 1 286 ? 16.93000 -21.88200 -6.38300  1.000 78.66356  ? 1702 GLY A N     1 
ATOM   1991 C  CA    . GLY A 1 286 ? 18.09900 -22.43000 -5.72000  1.000 78.72856  ? 1702 GLY A CA    1 
ATOM   1992 C  C     . GLY A 1 286 ? 17.97400 -23.87600 -5.30600  1.000 87.68157  ? 1702 GLY A C     1 
ATOM   1993 O  O     . GLY A 1 286 ? 18.42800 -24.24200 -4.21500  1.000 94.64442  ? 1702 GLY A O     1 
ATOM   1994 N  N     . LYS A 1 287 ? 17.36400 -24.70900 -6.14500  1.000 87.90898  ? 1703 LYS A N     1 
ATOM   1995 C  CA    . LYS A 1 287 ? 17.26000 -26.14200 -5.90000  1.000 94.09070  ? 1703 LYS A CA    1 
ATOM   1996 C  C     . LYS A 1 287 ? 18.05100 -26.87100 -6.97700  1.000 101.21866 ? 1703 LYS A C     1 
ATOM   1997 O  O     . LYS A 1 287 ? 17.76600 -26.71700 -8.16900  1.000 98.96896  ? 1703 LYS A O     1 
ATOM   1998 C  CB    . LYS A 1 287 ? 15.80100 -26.60100 -5.89000  1.000 91.07064  ? 1703 LYS A CB    1 
ATOM   1999 C  CG    . LYS A 1 287 ? 15.11600 -26.43600 -4.53400  1.000 88.79043  ? 1703 LYS A CG    1 
ATOM   2000 C  CD    . LYS A 1 287 ? 15.30000 -27.67300 -3.65200  1.000 93.57802  ? 1703 LYS A CD    1 
ATOM   2001 C  CE    . LYS A 1 287 ? 14.82000 -27.42900 -2.21200  1.000 88.04009  ? 1703 LYS A CE    1 
ATOM   2002 N  NZ    . LYS A 1 287 ? 14.31900 -28.67800 -1.55400  1.000 91.03815  ? 1703 LYS A NZ    1 
ATOM   2003 N  N     . MET A 1 288 ? 19.04000 -27.65800 -6.55300  1.000 109.15540 ? 1704 MET A N     1 
ATOM   2004 C  CA    . MET A 1 288 ? 19.93900 -28.35500 -7.47500  1.000 112.08107 ? 1704 MET A CA    1 
ATOM   2005 C  C     . MET A 1 288 ? 19.44300 -29.76300 -7.79800  1.000 112.67736 ? 1704 MET A C     1 
ATOM   2006 O  O     . MET A 1 288 ? 19.36100 -30.15200 -8.96200  1.000 116.28004 ? 1704 MET A O     1 
ATOM   2007 C  CB    . MET A 1 288 ? 21.35300 -28.42000 -6.88500  1.000 114.46734 ? 1704 MET A CB    1 
ATOM   2008 C  CG    . MET A 1 288 ? 22.38700 -29.07000 -7.80100  1.000 124.19868 ? 1704 MET A CG    1 
ATOM   2009 S  SD    . MET A 1 288 ? 22.86400 -30.73800 -7.29100  1.000 136.03813 ? 1704 MET A SD    1 
ATOM   2010 C  CE    . MET A 1 288 ? 24.45300 -30.43500 -6.51500  1.000 130.31761 ? 1704 MET A CE    1 
ATOM   2011 N  N     . ALA B 2 1   ? 5.08000  -21.41600 -19.19000 1.000 102.13742 ? 29   ALA B N     1 
ATOM   2012 C  CA    . ALA B 2 1   ? 5.90000  -20.60900 -18.29400 1.000 92.62313  ? 29   ALA B CA    1 
ATOM   2013 C  C     . ALA B 2 1   ? 5.20800  -19.30100 -17.92900 1.000 89.20166  ? 29   ALA B C     1 
ATOM   2014 O  O     . ALA B 2 1   ? 4.36300  -18.81000 -18.68000 1.000 100.75305 ? 29   ALA B O     1 
ATOM   2015 C  CB    . ALA B 2 1   ? 7.25500  -20.32600 -18.93200 1.000 84.52623  ? 29   ALA B CB    1 
ATOM   2016 N  N     . PRO B 2 2   ? 5.55100  -18.74200 -16.76900 1.000 81.23187  ? 30   PRO B N     1 
ATOM   2017 C  CA    . PRO B 2 2   ? 5.09900  -17.38200 -16.45600 1.000 75.50235  ? 30   PRO B CA    1 
ATOM   2018 C  C     . PRO B 2 2   ? 5.63600  -16.38000 -17.47300 1.000 67.38842  ? 30   PRO B C     1 
ATOM   2019 O  O     . PRO B 2 2   ? 6.72100  -16.54900 -18.03300 1.000 61.89501  ? 30   PRO B O     1 
ATOM   2020 C  CB    . PRO B 2 2   ? 5.66300  -17.12600 -15.04700 1.000 66.87084  ? 30   PRO B CB    1 
ATOM   2021 C  CG    . PRO B 2 2   ? 6.61300  -18.24400 -14.76400 1.000 66.40246  ? 30   PRO B CG    1 
ATOM   2022 C  CD    . PRO B 2 2   ? 6.19000  -19.39700 -15.61600 1.000 76.52788  ? 30   PRO B CD    1 
ATOM   2023 N  N     . SER B 2 3   ? 4.85200  -15.32500 -17.71000 1.000 67.92044  ? 31   SER B N     1 
ATOM   2024 C  CA    . SER B 2 3   ? 5.25600  -14.29100 -18.65800 1.000 65.94626  ? 31   SER B CA    1 
ATOM   2025 C  C     . SER B 2 3   ? 6.51000  -13.55800 -18.18300 1.000 64.25971  ? 31   SER B C     1 
ATOM   2026 O  O     . SER B 2 3   ? 7.45500  -13.36000 -18.95300 1.000 62.04841  ? 31   SER B O     1 
ATOM   2027 C  CB    . SER B 2 3   ? 4.10900  -13.31300 -18.86900 1.000 71.18877  ? 31   SER B CB    1 
ATOM   2028 O  OG    . SER B 2 3   ? 3.31400  -13.72700 -19.96900 1.000 83.72286  ? 31   SER B OG    1 
ATOM   2029 N  N     . THR B 2 4   ? 6.53800  -13.14400 -16.91300 1.000 60.81751  ? 32   THR B N     1 
ATOM   2030 C  CA    . THR B 2 4   ? 7.69700  -12.48600 -16.31500 1.000 59.27403  ? 32   THR B CA    1 
ATOM   2031 C  C     . THR B 2 4   ? 7.98800  -13.13200 -14.96700 1.000 58.51299  ? 32   THR B C     1 
ATOM   2032 O  O     . THR B 2 4   ? 7.20000  -13.93600 -14.45800 1.000 56.78806  ? 32   THR B O     1 
ATOM   2033 C  CB    . THR B 2 4   ? 7.47000  -10.98100 -16.14800 1.000 52.62885  ? 32   THR B CB    1 
ATOM   2034 O  OG1   . THR B 2 4   ? 6.40400  -10.76700 -15.22600 1.000 61.25222  ? 32   THR B OG1   1 
ATOM   2035 C  CG2   . THR B 2 4   ? 7.10400  -10.31200 -17.49400 1.000 65.19505  ? 32   THR B CG2   1 
ATOM   2036 N  N     . GLY B 2 5   ? 9.13100  -12.76900 -14.38700 1.000 52.95043  ? 33   GLY B N     1 
ATOM   2037 C  CA    . GLY B 2 5   ? 9.51100  -13.24100 -13.06500 1.000 54.83488  ? 33   GLY B CA    1 
ATOM   2038 C  C     . GLY B 2 5   ? 10.95900 -13.69100 -12.98700 1.000 53.37195  ? 33   GLY B C     1 
ATOM   2039 O  O     . GLY B 2 5   ? 11.55700 -14.12500 -13.97100 1.000 50.38122  ? 33   GLY B O     1 
ATOM   2040 N  N     . GLY B 2 6   ? 11.52700 -13.58200 -11.79200 1.000 47.33969  ? 34   GLY B N     1 
ATOM   2041 C  CA    . GLY B 2 6   ? 12.89100 -14.01600 -11.55700 1.000 49.82608  ? 34   GLY B CA    1 
ATOM   2042 C  C     . GLY B 2 6   ? 13.25600 -13.86200 -10.08900 1.000 53.53182  ? 34   GLY B C     1 
ATOM   2043 O  O     . GLY B 2 6   ? 12.43000 -13.47400 -9.26000  1.000 60.67719  ? 34   GLY B O     1 
ATOM   2044 N  N     . VAL B 2 7   ? 14.51400 -14.17400 -9.77700  1.000 50.18638  ? 35   VAL B N     1 
ATOM   2045 C  CA    . VAL B 2 7   ? 15.02000 -14.21600 -8.40900  1.000 51.93341  ? 35   VAL B CA    1 
ATOM   2046 C  C     . VAL B 2 7   ? 16.37000 -13.51500 -8.37000  1.000 51.73491  ? 35   VAL B C     1 
ATOM   2047 O  O     . VAL B 2 7   ? 17.20600 -13.71400 -9.25600  1.000 50.48008  ? 35   VAL B O     1 
ATOM   2048 C  CB    . VAL B 2 7   ? 15.14500 -15.67000 -7.90900  1.000 52.12943  ? 35   VAL B CB    1 
ATOM   2049 C  CG1   . VAL B 2 7   ? 15.63600 -15.70400 -6.50500  1.000 54.01732  ? 35   VAL B CG1   1 
ATOM   2050 C  CG2   . VAL B 2 7   ? 13.80500 -16.38800 -7.98400  1.000 53.00024  ? 35   VAL B CG2   1 
ATOM   2051 N  N     . MET B 2 8   ? 16.58600 -12.67700 -7.35800  1.000 50.75651  ? 36   MET B N     1 
ATOM   2052 C  CA    . MET B 2 8   ? 17.88100 -12.02700 -7.20000  1.000 52.13860  ? 36   MET B CA    1 
ATOM   2053 C  C     . MET B 2 8   ? 18.80200 -12.95100 -6.41500  1.000 56.73728  ? 36   MET B C     1 
ATOM   2054 O  O     . MET B 2 8   ? 18.34600 -13.70100 -5.55100  1.000 56.91919  ? 36   MET B O     1 
ATOM   2055 C  CB    . MET B 2 8   ? 17.75000 -10.68500 -6.48000  1.000 48.49363  ? 36   MET B CB    1 
ATOM   2056 C  CG    . MET B 2 8   ? 16.57000 -9.84900  -6.93200  1.000 49.48350  ? 36   MET B CG    1 
ATOM   2057 S  SD    . MET B 2 8   ? 16.20700 -8.42500  -5.86700  1.000 48.25167  ? 36   MET B SD    1 
ATOM   2058 C  CE    . MET B 2 8   ? 14.75700 -9.03400  -5.00500  1.000 48.32582  ? 36   MET B CE    1 
ATOM   2059 N  N     . LYS B 2 9   ? 20.10000 -12.88600 -6.71800  1.000 58.48010  ? 37   LYS B N     1 
ATOM   2060 C  CA    . LYS B 2 9   ? 21.11400 -13.69000 -6.04100  1.000 64.32029  ? 37   LYS B CA    1 
ATOM   2061 C  C     . LYS B 2 9   ? 22.23600 -12.81300 -5.49900  1.000 74.74081  ? 37   LYS B C     1 
ATOM   2062 O  O     . LYS B 2 9   ? 22.81700 -12.01400 -6.25800  1.000 73.12342  ? 37   LYS B O     1 
ATOM   2063 C  CB    . LYS B 2 9   ? 21.66700 -14.74700 -6.98700  1.000 69.33120  ? 37   LYS B CB    1 
ATOM   2064 C  CG    . LYS B 2 9   ? 20.58800 -15.65200 -7.54500  1.000 63.43115  ? 37   LYS B CG    1 
ATOM   2065 C  CD    . LYS B 2 9   ? 20.61900 -17.03600 -6.92900  1.000 67.54036  ? 37   LYS B CD    1 
ATOM   2066 C  CE    . LYS B 2 9   ? 19.58400 -17.95200 -7.62500  1.000 68.43828  ? 37   LYS B CE    1 
ATOM   2067 N  NZ    . LYS B 2 9   ? 20.00000 -19.38200 -7.74900  1.000 69.87828  ? 37   LYS B NZ    1 
ATOM   2068 N  N     . PRO B 2 10  ? 22.56700 -12.90900 -4.20100  1.000 79.49906  ? 38   PRO B N     1 
ATOM   2069 C  CA    . PRO B 2 10  ? 23.75500 -12.22500 -3.66400  1.000 84.11466  ? 38   PRO B CA    1 
ATOM   2070 C  C     . PRO B 2 10  ? 25.03100 -12.35800 -4.49100  1.000 94.81921  ? 38   PRO B C     1 
ATOM   2071 O  O     . PRO B 2 10  ? 25.62200 -11.34900 -4.89400  1.000 95.20397  ? 38   PRO B O     1 
ATOM   2072 C  CB    . PRO B 2 10  ? 23.93000 -12.88800 -2.29300  1.000 88.34541  ? 38   PRO B CB    1 
ATOM   2073 C  CG    . PRO B 2 10  ? 22.57200 -13.45200 -1.92100  1.000 82.75947  ? 38   PRO B CG    1 
ATOM   2074 C  CD    . PRO B 2 10  ? 21.66400 -13.35200 -3.12600  1.000 76.03407  ? 38   PRO B CD    1 
ATOM   2075 N  N     . HIS B 2 11  ? 25.49100 -13.58400 -4.72100  1.000 107.96181 ? 39   HIS B N     1 
ATOM   2076 C  CA    . HIS B 2 11  ? 26.68900 -13.79300 -5.52800  1.000 128.77483 ? 39   HIS B CA    1 
ATOM   2077 C  C     . HIS B 2 11  ? 26.32000 -14.19700 -6.94900  1.000 139.62613 ? 39   HIS B C     1 
ATOM   2078 O  O     . HIS B 2 11  ? 26.34900 -15.37700 -7.29600  1.000 137.16268 ? 39   HIS B O     1 
ATOM   2079 C  CB    . HIS B 2 11  ? 27.59000 -14.85300 -4.89900  1.000 134.69396 ? 39   HIS B CB    1 
HETATM 2080 ZN ZN    . ZN  C 3 .   ? 33.96500 -7.50500  19.60700  1.000 57.66777  2 1801 ZN  A ZN    1 
HETATM 2081 ZN ZN    . ZN  D 3 .   ? 30.29200 -6.59000  20.44900  1.000 52.24660  2 1802 ZN  A ZN    1 
HETATM 2082 ZN ZN    . ZN  E 3 .   ? 22.08100 -2.08400  -16.52400 1.000 47.64374  2 1803 ZN  A ZN    1 
HETATM 2083 N  N     . SAM F 4 .   ? 11.26300 -0.49400  -8.26000  1.000 45.58881  ? 1804 SAM A N     1 
HETATM 2084 C  CA    . SAM F 4 .   ? 10.57800 -1.42600  -7.36700  1.000 49.43506  ? 1804 SAM A CA    1 
HETATM 2085 C  C     . SAM F 4 .   ? 9.22800  -0.90700  -6.89900  1.000 51.09374  ? 1804 SAM A C     1 
HETATM 2086 O  O     . SAM F 4 .   ? 8.79200  0.16900   -7.32500  1.000 51.77876  ? 1804 SAM A O     1 
HETATM 2087 O  OXT   . SAM F 4 .   ? 8.55600  -1.56200  -6.09500  1.000 48.60970  ? 1804 SAM A OXT   1 
HETATM 2088 C  CB    . SAM F 4 .   ? 11.43900 -1.72600  -6.14900  1.000 46.77824  ? 1804 SAM A CB    1 
HETATM 2089 C  CG    . SAM F 4 .   ? 12.56700 -2.69400  -6.46400  1.000 47.86043  ? 1804 SAM A CG    1 
HETATM 2090 S  SD    . SAM F 4 .   ? 11.90200 -4.34600  -6.78200  1.000 44.21724  ? 1804 SAM A SD    1 
HETATM 2091 C  CE    . SAM F 4 .   ? 13.05200 -5.25800  -5.72300  1.000 50.15179  ? 1804 SAM A CE    1 
HETATM 2092 C  "C5'" . SAM F 4 .   ? 12.61200 -4.85500  -8.37900  1.000 47.53660  ? 1804 SAM A "C5'" 1 
HETATM 2093 C  "C4'" . SAM F 4 .   ? 11.71800 -4.46300  -9.55200  1.000 43.85928  ? 1804 SAM A "C4'" 1 
HETATM 2094 O  "O4'" . SAM F 4 .   ? 11.94400 -3.10400  -9.86500  1.000 42.54236  ? 1804 SAM A "O4'" 1 
HETATM 2095 C  "C3'" . SAM F 4 .   ? 11.96600 -5.28000  -10.81500 1.000 46.71829  ? 1804 SAM A "C3'" 1 
HETATM 2096 O  "O3'" . SAM F 4 .   ? 10.98000 -6.28700  -10.88300 1.000 46.59181  ? 1804 SAM A "O3'" 1 
HETATM 2097 C  "C2'" . SAM F 4 .   ? 11.77700 -4.26400  -11.91500 1.000 42.59225  ? 1804 SAM A "C2'" 1 
HETATM 2098 O  "O2'" . SAM F 4 .   ? 10.38200 -4.16500  -12.11000 1.000 39.55967  ? 1804 SAM A "O2'" 1 
HETATM 2099 C  "C1'" . SAM F 4 .   ? 12.17900 -2.96000  -11.25800 1.000 47.24587  ? 1804 SAM A "C1'" 1 
HETATM 2100 N  N9    . SAM F 4 .   ? 13.60400 -2.63400  -11.48900 1.000 47.44932  ? 1804 SAM A N9    1 
HETATM 2101 C  C8    . SAM F 4 .   ? 14.60600 -2.56800  -10.54900 1.000 42.53310  ? 1804 SAM A C8    1 
HETATM 2102 N  N7    . SAM F 4 .   ? 15.77400 -2.22000  -11.14700 1.000 42.90006  ? 1804 SAM A N7    1 
HETATM 2103 C  C5    . SAM F 4 .   ? 15.52800 -2.08500  -12.48400 1.000 44.36987  ? 1804 SAM A C5    1 
HETATM 2104 C  C6    . SAM F 4 .   ? 16.34100 -1.75900  -13.57100 1.000 44.97740  ? 1804 SAM A C6    1 
HETATM 2105 N  N6    . SAM F 4 .   ? 17.64200 -1.49700  -13.43300 1.000 45.92788  ? 1804 SAM A N6    1 
HETATM 2106 N  N1    . SAM F 4 .   ? 15.77900 -1.68600  -14.82700 1.000 47.51475  ? 1804 SAM A N1    1 
HETATM 2107 C  C2    . SAM F 4 .   ? 14.43900 -1.92800  -15.00300 1.000 46.74067  ? 1804 SAM A C2    1 
HETATM 2108 N  N3    . SAM F 4 .   ? 13.63800 -2.25400  -13.92800 1.000 45.97884  ? 1804 SAM A N3    1 
HETATM 2109 C  C4    . SAM F 4 .   ? 14.17200 -2.33000  -12.69600 1.000 41.93844  ? 1804 SAM A C4    1 
HETATM 2110 O  O     . HOH G 5 .   ? 13.93400 -22.04000 -3.78600  1.000 66.94243  ? 1901 HOH A O     1 
HETATM 2111 O  O     . HOH G 5 .   ? 26.43500 -5.32300  13.00400  1.000 52.77374  ? 1902 HOH A O     1 
HETATM 2112 O  O     . HOH G 5 .   ? 16.00100 -14.63800 9.23900   1.000 55.47185  ? 1903 HOH A O     1 
HETATM 2113 O  O     . HOH G 5 .   ? 6.49600  -11.00600 1.25300   1.000 48.73877  ? 1904 HOH A O     1 
HETATM 2114 O  O     . HOH G 5 .   ? 20.69700 -8.63800  -12.68800 1.000 47.21337  ? 1905 HOH A O     1 
HETATM 2115 O  O     . HOH G 5 .   ? 23.68200 0.51900   23.26800  1.000 54.19283  ? 1906 HOH A O     1 
HETATM 2116 O  O     . HOH G 5 .   ? 6.38500  -15.40700 -11.15700 1.000 53.39271  ? 1907 HOH A O     1 
HETATM 2117 O  O     . HOH G 5 .   ? 24.53900 -3.87200  23.71400  1.000 46.21485  ? 1908 HOH A O     1 
HETATM 2118 O  O     . HOH G 5 .   ? 15.26500 -10.45300 10.13800  1.000 50.63396  ? 1909 HOH A O     1 
HETATM 2119 O  O     . HOH G 5 .   ? 16.96200 2.20100   -5.94000  1.000 43.84756  ? 1910 HOH A O     1 
HETATM 2120 O  O     . HOH G 5 .   ? 27.45400 0.56600   14.68400  1.000 53.27210  ? 1911 HOH A O     1 
HETATM 2121 O  O     . HOH G 5 .   ? 6.12400  -0.50000  -5.56300  1.000 53.75639  ? 1912 HOH A O     1 
HETATM 2122 O  O     . HOH G 5 .   ? 20.81100 1.27100   -19.15500 1.000 53.05632  ? 1913 HOH A O     1 
HETATM 2123 O  O     . HOH G 5 .   ? 19.40300 1.67500   -11.28300 1.000 46.77726  ? 1914 HOH A O     1 
HETATM 2124 O  O     . HOH G 5 .   ? 23.91300 3.03900   -11.33700 1.000 52.89297  ? 1915 HOH A O     1 
HETATM 2125 O  O     . HOH G 5 .   ? 24.60700 -15.70700 15.57300  1.000 57.95481  ? 1916 HOH A O     1 
HETATM 2126 O  O     . HOH G 5 .   ? 18.52300 -15.31100 -16.13900 1.000 58.79362  ? 1917 HOH A O     1 
HETATM 2127 O  O     . HOH G 5 .   ? 21.58000 3.38000   -12.04700 1.000 53.35245  ? 1918 HOH A O     1 
HETATM 2128 O  O     . HOH G 5 .   ? 27.24900 3.52100   -8.85300  1.000 60.70467  ? 1919 HOH A O     1 
HETATM 2129 O  O     . HOH G 5 .   ? 33.27100 6.41000   21.59400  1.000 65.37731  ? 1920 HOH A O     1 
HETATM 2130 O  O     . HOH G 5 .   ? 4.76900  -0.81100  -3.03800  1.000 47.91209  ? 1921 HOH A O     1 
HETATM 2131 O  O     . HOH G 5 .   ? 8.85400  4.75100   -12.97900 1.000 49.86608  ? 1922 HOH A O     1 
HETATM 2132 O  O     . HOH G 5 .   ? 25.55300 -1.70600  17.41900  1.000 49.61743  ? 1923 HOH A O     1 
HETATM 2133 O  O     . HOH G 5 .   ? 30.17200 -2.57700  7.45500   1.000 63.28975  ? 1924 HOH A O     1 
HETATM 2134 O  O     . HOH G 5 .   ? 5.04400  -25.44000 3.08000   1.000 69.57792  ? 1925 HOH A O     1 
HETATM 2135 O  O     . HOH G 5 .   ? 26.11300 -5.55400  -5.78300  1.000 51.79136  ? 1926 HOH A O     1 
HETATM 2136 O  O     . HOH G 5 .   ? 24.78300 -3.59400  28.67900  1.000 54.48379  ? 1927 HOH A O     1 
HETATM 2137 O  O     . HOH G 5 .   ? 15.33200 -10.17600 -17.31100 1.000 41.49591  ? 1928 HOH A O     1 
HETATM 2138 O  O     . HOH G 5 .   ? 3.70200  -4.86300  -9.70200  1.000 42.70797  ? 1929 HOH A O     1 
HETATM 2139 O  O     . HOH G 5 .   ? 11.64100 -4.91700  -21.37100 1.000 50.63581  ? 1930 HOH A O     1 
HETATM 2140 O  O     . HOH G 5 .   ? 28.02300 -11.82700 21.86600  1.000 59.84128  ? 1931 HOH A O     1 
HETATM 2141 O  O     . HOH G 5 .   ? 25.91800 -8.05300  -3.87700  1.000 57.69058  ? 1932 HOH A O     1 
HETATM 2142 O  O     . HOH G 5 .   ? 32.07200 0.35900   13.82800  1.000 55.50212  ? 1933 HOH A O     1 
HETATM 2143 O  O     . HOH G 5 .   ? 27.60600 0.96400   9.14200   1.000 52.94502  ? 1934 HOH A O     1 
HETATM 2144 O  O     . HOH G 5 .   ? 13.62400 -21.58300 -0.85400  1.000 64.17630  ? 1935 HOH A O     1 
HETATM 2145 O  O     . HOH G 5 .   ? 20.75700 -10.53900 23.01500  1.000 47.65938  ? 1936 HOH A O     1 
HETATM 2146 O  O     . HOH G 5 .   ? 30.31200 -10.43000 21.69200  1.000 62.22118  ? 1937 HOH A O     1 
HETATM 2147 O  O     . HOH G 5 .   ? 12.09800 0.71500   6.40900   1.000 50.00718  ? 1938 HOH A O     1 
HETATM 2148 O  O     . HOH G 5 .   ? 14.88900 5.16200   -14.40400 1.000 38.80501  ? 1939 HOH A O     1 
HETATM 2149 O  O     . HOH G 5 .   ? 29.85700 -0.36200  12.29900  1.000 47.79156  ? 1940 HOH A O     1 
HETATM 2150 O  O     . HOH G 5 .   ? 31.62500 -4.59300  8.97600   1.000 53.61022  ? 1941 HOH A O     1 
HETATM 2151 O  O     . HOH G 5 .   ? 23.90300 -4.68200  26.21300  1.000 56.34681  ? 1942 HOH A O     1 
# 
