data_8RV1
# 
_entry.id   8RV1 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8RV1         pdb_00008rv1 10.2210/pdb8rv1/pdb 
WWPDB D_1292136291 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-02-12 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8RV1 
_pdbx_database_status.recvd_initial_deposition_date   2024-01-31 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              christopher.schofield@chem.ox.ac.uk 
_pdbx_contact_author.name_first         Christopher 
_pdbx_contact_author.name_last          Schofield 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-0290-6565 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Fiorini, G.'     1 ? 
'Schofield, C.J.' 2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'investigating gatekeeper residues in prolyl hydroxyalse 2' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Fiorini, G.'     1 ? 
primary 'Schofield, C.J.' 2 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Egl nine homolog 1'                          25450.930 1   1.14.11.29 ? ? ? 
2 polymer     syn 'Endothelial PAS domain-containing protein 1' 2325.544  1   ?          ? ? ? 
3 non-polymer syn 'ACETATE ION'                                 59.044    2   ?          ? ? ? 
4 water       nat water                                         18.015    272 ?          ? ? ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
1 
;Hypoxia-inducible factor prolyl hydroxylase 2,HIF-PH2,HIF-prolyl hydroxylase 2,HPH-2,Prolyl hydroxylase domain-containing protein 2,PHD2,SM-20
;
2 
;EPAS-1,Basic-helix-loop-helix-PAS protein MOP2,Class E basic helix-loop-helix protein 73,bHLHe73,HIF-1-alpha-like factor,HLF,Hypoxia-inducible factor 2-alpha,HIF-2-alpha,HIF2-alpha,Member of PAS protein 2,PAS domain-containing protein 2
;
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no  
;PNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIE
GKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSG
GILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAISVWYFDADERARAKVKYLTGE
;
;PNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIE
GKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSG
GILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAISVWYFDADERARAKVKYLTGE
;
A ? 
2 'polypeptide(L)' no yes 'ELDLETLA(HYP)YIPMDGEDFQL' ELDLETLAPYIPMDGEDFQL B ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 'ACETATE ION' ACT 
4 water         HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   PRO n 
1 2   ASN n 
1 3   GLY n 
1 4   GLN n 
1 5   THR n 
1 6   LYS n 
1 7   PRO n 
1 8   LEU n 
1 9   PRO n 
1 10  ALA n 
1 11  LEU n 
1 12  LYS n 
1 13  LEU n 
1 14  ALA n 
1 15  LEU n 
1 16  GLU n 
1 17  TYR n 
1 18  ILE n 
1 19  VAL n 
1 20  PRO n 
1 21  CYS n 
1 22  MET n 
1 23  ASN n 
1 24  LYS n 
1 25  HIS n 
1 26  GLY n 
1 27  ILE n 
1 28  CYS n 
1 29  VAL n 
1 30  VAL n 
1 31  ASP n 
1 32  ASP n 
1 33  PHE n 
1 34  LEU n 
1 35  GLY n 
1 36  LYS n 
1 37  GLU n 
1 38  THR n 
1 39  GLY n 
1 40  GLN n 
1 41  GLN n 
1 42  ILE n 
1 43  GLY n 
1 44  ASP n 
1 45  GLU n 
1 46  VAL n 
1 47  ARG n 
1 48  ALA n 
1 49  LEU n 
1 50  HIS n 
1 51  ASP n 
1 52  THR n 
1 53  GLY n 
1 54  LYS n 
1 55  PHE n 
1 56  THR n 
1 57  ASP n 
1 58  GLY n 
1 59  GLN n 
1 60  LEU n 
1 61  VAL n 
1 62  SER n 
1 63  GLN n 
1 64  LYS n 
1 65  SER n 
1 66  ASP n 
1 67  SER n 
1 68  SER n 
1 69  LYS n 
1 70  ASP n 
1 71  ILE n 
1 72  ARG n 
1 73  GLY n 
1 74  ASP n 
1 75  LYS n 
1 76  ILE n 
1 77  THR n 
1 78  TRP n 
1 79  ILE n 
1 80  GLU n 
1 81  GLY n 
1 82  LYS n 
1 83  GLU n 
1 84  PRO n 
1 85  GLY n 
1 86  CYS n 
1 87  GLU n 
1 88  THR n 
1 89  ILE n 
1 90  GLY n 
1 91  LEU n 
1 92  LEU n 
1 93  MET n 
1 94  SER n 
1 95  SER n 
1 96  MET n 
1 97  ASP n 
1 98  ASP n 
1 99  LEU n 
1 100 ILE n 
1 101 ARG n 
1 102 HIS n 
1 103 CYS n 
1 104 ASN n 
1 105 GLY n 
1 106 LYS n 
1 107 LEU n 
1 108 GLY n 
1 109 SER n 
1 110 TYR n 
1 111 LYS n 
1 112 ILE n 
1 113 ASN n 
1 114 GLY n 
1 115 ARG n 
1 116 THR n 
1 117 LYS n 
1 118 ALA n 
1 119 MET n 
1 120 VAL n 
1 121 ALA n 
1 122 CYS n 
1 123 TYR n 
1 124 PRO n 
1 125 GLY n 
1 126 ASN n 
1 127 GLY n 
1 128 THR n 
1 129 GLY n 
1 130 TYR n 
1 131 VAL n 
1 132 ARG n 
1 133 HIS n 
1 134 VAL n 
1 135 ASP n 
1 136 ASN n 
1 137 PRO n 
1 138 ASN n 
1 139 GLY n 
1 140 ASP n 
1 141 GLY n 
1 142 ARG n 
1 143 CYS n 
1 144 VAL n 
1 145 THR n 
1 146 CYS n 
1 147 ILE n 
1 148 TYR n 
1 149 TYR n 
1 150 LEU n 
1 151 ASN n 
1 152 LYS n 
1 153 ASP n 
1 154 TRP n 
1 155 ASP n 
1 156 ALA n 
1 157 LYS n 
1 158 VAL n 
1 159 SER n 
1 160 GLY n 
1 161 GLY n 
1 162 ILE n 
1 163 LEU n 
1 164 ARG n 
1 165 ILE n 
1 166 PHE n 
1 167 PRO n 
1 168 GLU n 
1 169 GLY n 
1 170 LYS n 
1 171 ALA n 
1 172 GLN n 
1 173 PHE n 
1 174 ALA n 
1 175 ASP n 
1 176 ILE n 
1 177 GLU n 
1 178 PRO n 
1 179 LYS n 
1 180 PHE n 
1 181 ASP n 
1 182 ARG n 
1 183 LEU n 
1 184 LEU n 
1 185 PHE n 
1 186 PHE n 
1 187 TRP n 
1 188 SER n 
1 189 ASP n 
1 190 ARG n 
1 191 ARG n 
1 192 ASN n 
1 193 PRO n 
1 194 HIS n 
1 195 GLU n 
1 196 VAL n 
1 197 GLN n 
1 198 PRO n 
1 199 ALA n 
1 200 TYR n 
1 201 ALA n 
1 202 THR n 
1 203 ARG n 
1 204 TYR n 
1 205 ALA n 
1 206 ILE n 
1 207 SER n 
1 208 VAL n 
1 209 TRP n 
1 210 TYR n 
1 211 PHE n 
1 212 ASP n 
1 213 ALA n 
1 214 ASP n 
1 215 GLU n 
1 216 ARG n 
1 217 ALA n 
1 218 ARG n 
1 219 ALA n 
1 220 LYS n 
1 221 VAL n 
1 222 LYS n 
1 223 TYR n 
1 224 LEU n 
1 225 THR n 
1 226 GLY n 
1 227 GLU n 
2 1   GLU n 
2 2   LEU n 
2 3   ASP n 
2 4   LEU n 
2 5   GLU n 
2 6   THR n 
2 7   LEU n 
2 8   ALA n 
2 9   HYP n 
2 10  TYR n 
2 11  ILE n 
2 12  PRO n 
2 13  MET n 
2 14  ASP n 
2 15  GLY n 
2 16  GLU n 
2 17  ASP n 
2 18  PHE n 
2 19  GLN n 
2 20  LEU n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   227 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'EGLN1, C1orf12, PNAS-118, PNAS-137' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
_pdbx_entity_src_syn.entity_id              2 
_pdbx_entity_src_syn.pdbx_src_id            1 
_pdbx_entity_src_syn.pdbx_alt_source_flag   sample 
_pdbx_entity_src_syn.pdbx_beg_seq_num       1 
_pdbx_entity_src_syn.pdbx_end_seq_num       20 
_pdbx_entity_src_syn.organism_scientific    'Homo sapiens' 
_pdbx_entity_src_syn.organism_common_name   human 
_pdbx_entity_src_syn.ncbi_taxonomy_id       9606 
_pdbx_entity_src_syn.details                ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ACT non-polymer         . 'ACETATE ION'    ?              'C2 H3 O2 -1'    59.044  
ALA 'L-peptide linking' y ALANINE          ?              'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE         ?              'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE       ?              'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'  ?              'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE         ?              'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE        ?              'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'  ?              'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE          ?              'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE        ?              'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER            ?              'H2 O'           18.015  
HYP 'L-peptide linking' n 4-HYDROXYPROLINE HYDROXYPROLINE 'C5 H9 N O3'     131.130 
ILE 'L-peptide linking' y ISOLEUCINE       ?              'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE          ?              'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE           ?              'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE       ?              'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE    ?              'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE          ?              'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE           ?              'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE        ?              'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN       ?              'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE         ?              'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE           ?              'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   PRO 1   181 ?   ?   ?   A . n 
A 1 2   ASN 2   182 ?   ?   ?   A . n 
A 1 3   GLY 3   183 ?   ?   ?   A . n 
A 1 4   GLN 4   184 ?   ?   ?   A . n 
A 1 5   THR 5   185 ?   ?   ?   A . n 
A 1 6   LYS 6   186 ?   ?   ?   A . n 
A 1 7   PRO 7   187 ?   ?   ?   A . n 
A 1 8   LEU 8   188 188 LEU LEU A . n 
A 1 9   PRO 9   189 189 PRO PRO A . n 
A 1 10  ALA 10  190 190 ALA ALA A . n 
A 1 11  LEU 11  191 191 LEU LEU A . n 
A 1 12  LYS 12  192 192 LYS LYS A . n 
A 1 13  LEU 13  193 193 LEU LEU A . n 
A 1 14  ALA 14  194 194 ALA ALA A . n 
A 1 15  LEU 15  195 195 LEU LEU A . n 
A 1 16  GLU 16  196 196 GLU GLU A . n 
A 1 17  TYR 17  197 197 TYR TYR A . n 
A 1 18  ILE 18  198 198 ILE ILE A . n 
A 1 19  VAL 19  199 199 VAL VAL A . n 
A 1 20  PRO 20  200 200 PRO PRO A . n 
A 1 21  CYS 21  201 201 CYS CYS A . n 
A 1 22  MET 22  202 202 MET MET A . n 
A 1 23  ASN 23  203 203 ASN ASN A . n 
A 1 24  LYS 24  204 204 LYS LYS A . n 
A 1 25  HIS 25  205 205 HIS HIS A . n 
A 1 26  GLY 26  206 206 GLY GLY A . n 
A 1 27  ILE 27  207 207 ILE ILE A . n 
A 1 28  CYS 28  208 208 CYS CYS A . n 
A 1 29  VAL 29  209 209 VAL VAL A . n 
A 1 30  VAL 30  210 210 VAL VAL A . n 
A 1 31  ASP 31  211 211 ASP ASP A . n 
A 1 32  ASP 32  212 212 ASP ASP A . n 
A 1 33  PHE 33  213 213 PHE PHE A . n 
A 1 34  LEU 34  214 214 LEU LEU A . n 
A 1 35  GLY 35  215 215 GLY GLY A . n 
A 1 36  LYS 36  216 216 LYS LYS A . n 
A 1 37  GLU 37  217 217 GLU GLU A . n 
A 1 38  THR 38  218 218 THR THR A . n 
A 1 39  GLY 39  219 219 GLY GLY A . n 
A 1 40  GLN 40  220 220 GLN GLN A . n 
A 1 41  GLN 41  221 221 GLN GLN A . n 
A 1 42  ILE 42  222 222 ILE ILE A . n 
A 1 43  GLY 43  223 223 GLY GLY A . n 
A 1 44  ASP 44  224 224 ASP ASP A . n 
A 1 45  GLU 45  225 225 GLU GLU A . n 
A 1 46  VAL 46  226 226 VAL VAL A . n 
A 1 47  ARG 47  227 227 ARG ARG A . n 
A 1 48  ALA 48  228 228 ALA ALA A . n 
A 1 49  LEU 49  229 229 LEU LEU A . n 
A 1 50  HIS 50  230 230 HIS HIS A . n 
A 1 51  ASP 51  231 231 ASP ASP A . n 
A 1 52  THR 52  232 232 THR THR A . n 
A 1 53  GLY 53  233 233 GLY GLY A . n 
A 1 54  LYS 54  234 234 LYS LYS A . n 
A 1 55  PHE 55  235 235 PHE PHE A . n 
A 1 56  THR 56  236 236 THR THR A . n 
A 1 57  ASP 57  237 237 ASP ASP A . n 
A 1 58  GLY 58  238 238 GLY GLY A . n 
A 1 59  GLN 59  239 239 GLN GLN A . n 
A 1 60  LEU 60  240 240 LEU LEU A . n 
A 1 61  VAL 61  241 241 VAL VAL A . n 
A 1 62  SER 62  242 242 SER SER A . n 
A 1 63  GLN 63  243 243 GLN GLN A . n 
A 1 64  LYS 64  244 244 LYS LYS A . n 
A 1 65  SER 65  245 245 SER SER A . n 
A 1 66  ASP 66  246 246 ASP ASP A . n 
A 1 67  SER 67  247 247 SER SER A . n 
A 1 68  SER 68  248 248 SER SER A . n 
A 1 69  LYS 69  249 249 LYS LYS A . n 
A 1 70  ASP 70  250 250 ASP ASP A . n 
A 1 71  ILE 71  251 251 ILE ILE A . n 
A 1 72  ARG 72  252 252 ARG ARG A . n 
A 1 73  GLY 73  253 253 GLY GLY A . n 
A 1 74  ASP 74  254 254 ASP ASP A . n 
A 1 75  LYS 75  255 255 LYS LYS A . n 
A 1 76  ILE 76  256 256 ILE ILE A . n 
A 1 77  THR 77  257 257 THR THR A . n 
A 1 78  TRP 78  258 258 TRP TRP A . n 
A 1 79  ILE 79  259 259 ILE ILE A . n 
A 1 80  GLU 80  260 260 GLU GLU A . n 
A 1 81  GLY 81  261 261 GLY GLY A . n 
A 1 82  LYS 82  262 262 LYS LYS A . n 
A 1 83  GLU 83  263 263 GLU GLU A . n 
A 1 84  PRO 84  264 264 PRO PRO A . n 
A 1 85  GLY 85  265 265 GLY GLY A . n 
A 1 86  CYS 86  266 266 CYS CYS A . n 
A 1 87  GLU 87  267 267 GLU GLU A . n 
A 1 88  THR 88  268 268 THR THR A . n 
A 1 89  ILE 89  269 269 ILE ILE A . n 
A 1 90  GLY 90  270 270 GLY GLY A . n 
A 1 91  LEU 91  271 271 LEU LEU A . n 
A 1 92  LEU 92  272 272 LEU LEU A . n 
A 1 93  MET 93  273 273 MET MET A . n 
A 1 94  SER 94  274 274 SER SER A . n 
A 1 95  SER 95  275 275 SER SER A . n 
A 1 96  MET 96  276 276 MET MET A . n 
A 1 97  ASP 97  277 277 ASP ASP A . n 
A 1 98  ASP 98  278 278 ASP ASP A . n 
A 1 99  LEU 99  279 279 LEU LEU A . n 
A 1 100 ILE 100 280 280 ILE ILE A . n 
A 1 101 ARG 101 281 281 ARG ARG A . n 
A 1 102 HIS 102 282 282 HIS HIS A . n 
A 1 103 CYS 103 283 283 CYS CYS A . n 
A 1 104 ASN 104 284 284 ASN ASN A . n 
A 1 105 GLY 105 285 285 GLY GLY A . n 
A 1 106 LYS 106 286 286 LYS LYS A . n 
A 1 107 LEU 107 287 287 LEU LEU A . n 
A 1 108 GLY 108 288 288 GLY GLY A . n 
A 1 109 SER 109 289 289 SER SER A . n 
A 1 110 TYR 110 290 290 TYR TYR A . n 
A 1 111 LYS 111 291 291 LYS LYS A . n 
A 1 112 ILE 112 292 292 ILE ILE A . n 
A 1 113 ASN 113 293 293 ASN ASN A . n 
A 1 114 GLY 114 294 294 GLY GLY A . n 
A 1 115 ARG 115 295 295 ARG ARG A . n 
A 1 116 THR 116 296 296 THR THR A . n 
A 1 117 LYS 117 297 297 LYS LYS A . n 
A 1 118 ALA 118 298 298 ALA ALA A . n 
A 1 119 MET 119 299 299 MET MET A . n 
A 1 120 VAL 120 300 300 VAL VAL A . n 
A 1 121 ALA 121 301 301 ALA ALA A . n 
A 1 122 CYS 122 302 302 CYS CYS A . n 
A 1 123 TYR 123 303 303 TYR TYR A . n 
A 1 124 PRO 124 304 304 PRO PRO A . n 
A 1 125 GLY 125 305 305 GLY GLY A . n 
A 1 126 ASN 126 306 306 ASN ASN A . n 
A 1 127 GLY 127 307 307 GLY GLY A . n 
A 1 128 THR 128 308 308 THR THR A . n 
A 1 129 GLY 129 309 309 GLY GLY A . n 
A 1 130 TYR 130 310 310 TYR TYR A . n 
A 1 131 VAL 131 311 311 VAL VAL A . n 
A 1 132 ARG 132 312 312 ARG ARG A . n 
A 1 133 HIS 133 313 313 HIS HIS A . n 
A 1 134 VAL 134 314 314 VAL VAL A . n 
A 1 135 ASP 135 315 315 ASP ASP A . n 
A 1 136 ASN 136 316 316 ASN ASN A . n 
A 1 137 PRO 137 317 317 PRO PRO A . n 
A 1 138 ASN 138 318 318 ASN ASN A . n 
A 1 139 GLY 139 319 319 GLY GLY A . n 
A 1 140 ASP 140 320 320 ASP ASP A . n 
A 1 141 GLY 141 321 321 GLY GLY A . n 
A 1 142 ARG 142 322 322 ARG ARG A . n 
A 1 143 CYS 143 323 323 CYS CYS A . n 
A 1 144 VAL 144 324 324 VAL VAL A . n 
A 1 145 THR 145 325 325 THR THR A . n 
A 1 146 CYS 146 326 326 CYS CYS A . n 
A 1 147 ILE 147 327 327 ILE ILE A . n 
A 1 148 TYR 148 328 328 TYR TYR A . n 
A 1 149 TYR 149 329 329 TYR TYR A . n 
A 1 150 LEU 150 330 330 LEU LEU A . n 
A 1 151 ASN 151 331 331 ASN ASN A . n 
A 1 152 LYS 152 332 332 LYS LYS A . n 
A 1 153 ASP 153 333 333 ASP ASP A . n 
A 1 154 TRP 154 334 334 TRP TRP A . n 
A 1 155 ASP 155 335 335 ASP ASP A . n 
A 1 156 ALA 156 336 336 ALA ALA A . n 
A 1 157 LYS 157 337 337 LYS LYS A . n 
A 1 158 VAL 158 338 338 VAL VAL A . n 
A 1 159 SER 159 339 339 SER SER A . n 
A 1 160 GLY 160 340 340 GLY GLY A . n 
A 1 161 GLY 161 341 341 GLY GLY A . n 
A 1 162 ILE 162 342 342 ILE ILE A . n 
A 1 163 LEU 163 343 343 LEU LEU A . n 
A 1 164 ARG 164 344 344 ARG ARG A . n 
A 1 165 ILE 165 345 345 ILE ILE A . n 
A 1 166 PHE 166 346 346 PHE PHE A . n 
A 1 167 PRO 167 347 347 PRO PRO A . n 
A 1 168 GLU 168 348 348 GLU GLU A . n 
A 1 169 GLY 169 349 349 GLY GLY A . n 
A 1 170 LYS 170 350 350 LYS LYS A . n 
A 1 171 ALA 171 351 351 ALA ALA A . n 
A 1 172 GLN 172 352 352 GLN GLN A . n 
A 1 173 PHE 173 353 353 PHE PHE A . n 
A 1 174 ALA 174 354 354 ALA ALA A . n 
A 1 175 ASP 175 355 355 ASP ASP A . n 
A 1 176 ILE 176 356 356 ILE ILE A . n 
A 1 177 GLU 177 357 357 GLU GLU A . n 
A 1 178 PRO 178 358 358 PRO PRO A . n 
A 1 179 LYS 179 359 359 LYS LYS A . n 
A 1 180 PHE 180 360 360 PHE PHE A . n 
A 1 181 ASP 181 361 361 ASP ASP A . n 
A 1 182 ARG 182 362 362 ARG ARG A . n 
A 1 183 LEU 183 363 363 LEU LEU A . n 
A 1 184 LEU 184 364 364 LEU LEU A . n 
A 1 185 PHE 185 365 365 PHE PHE A . n 
A 1 186 PHE 186 366 366 PHE PHE A . n 
A 1 187 TRP 187 367 367 TRP TRP A . n 
A 1 188 SER 188 368 368 SER SER A . n 
A 1 189 ASP 189 369 369 ASP ASP A . n 
A 1 190 ARG 190 370 370 ARG ARG A . n 
A 1 191 ARG 191 371 371 ARG ARG A . n 
A 1 192 ASN 192 372 372 ASN ASN A . n 
A 1 193 PRO 193 373 373 PRO PRO A . n 
A 1 194 HIS 194 374 374 HIS HIS A . n 
A 1 195 GLU 195 375 375 GLU GLU A . n 
A 1 196 VAL 196 376 376 VAL VAL A . n 
A 1 197 GLN 197 377 377 GLN GLN A . n 
A 1 198 PRO 198 378 378 PRO PRO A . n 
A 1 199 ALA 199 379 379 ALA ALA A . n 
A 1 200 TYR 200 380 380 TYR TYR A . n 
A 1 201 ALA 201 381 381 ALA ALA A . n 
A 1 202 THR 202 382 382 THR THR A . n 
A 1 203 ARG 203 383 383 ARG ARG A . n 
A 1 204 TYR 204 384 384 TYR TYR A . n 
A 1 205 ALA 205 385 385 ALA ALA A . n 
A 1 206 ILE 206 386 386 ILE ILE A . n 
A 1 207 SER 207 387 387 SER SER A . n 
A 1 208 VAL 208 388 388 VAL VAL A . n 
A 1 209 TRP 209 389 389 TRP TRP A . n 
A 1 210 TYR 210 390 390 TYR TYR A . n 
A 1 211 PHE 211 391 391 PHE PHE A . n 
A 1 212 ASP 212 392 392 ASP ASP A . n 
A 1 213 ALA 213 393 393 ALA ALA A . n 
A 1 214 ASP 214 394 394 ASP ASP A . n 
A 1 215 GLU 215 395 395 GLU GLU A . n 
A 1 216 ARG 216 396 396 ARG ARG A . n 
A 1 217 ALA 217 397 397 ALA ALA A . n 
A 1 218 ARG 218 398 398 ARG ARG A . n 
A 1 219 ALA 219 399 399 ALA ALA A . n 
A 1 220 LYS 220 400 400 LYS LYS A . n 
A 1 221 VAL 221 401 401 VAL VAL A . n 
A 1 222 LYS 222 402 402 LYS LYS A . n 
A 1 223 TYR 223 403 403 TYR TYR A . n 
A 1 224 LEU 224 404 404 LEU LEU A . n 
A 1 225 THR 225 405 405 THR THR A . n 
A 1 226 GLY 226 406 406 GLY GLY A . n 
A 1 227 GLU 227 407 ?   ?   ?   A . n 
B 2 1   GLU 1   523 523 GLU GLU B . n 
B 2 2   LEU 2   524 524 LEU LEU B . n 
B 2 3   ASP 3   525 525 ASP ASP B . n 
B 2 4   LEU 4   526 526 LEU LEU B . n 
B 2 5   GLU 5   527 527 GLU GLU B . n 
B 2 6   THR 6   528 528 THR THR B . n 
B 2 7   LEU 7   529 529 LEU LEU B . n 
B 2 8   ALA 8   530 530 ALA ALA B . n 
B 2 9   HYP 9   531 531 HYP HYP B . n 
B 2 10  TYR 10  532 532 TYR TYR B . n 
B 2 11  ILE 11  533 533 ILE ILE B . n 
B 2 12  PRO 12  534 534 PRO PRO B . n 
B 2 13  MET 13  535 535 MET MET B . n 
B 2 14  ASP 14  536 536 ASP ASP B . n 
B 2 15  GLY 15  537 537 GLY GLY B . n 
B 2 16  GLU 16  538 538 GLU GLU B . n 
B 2 17  ASP 17  539 539 ASP ASP B . n 
B 2 18  PHE 18  540 540 PHE PHE B . n 
B 2 19  GLN 19  541 541 GLN GLN B . n 
B 2 20  LEU 20  542 542 LEU LEU B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        HYP 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   HYP 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 3 ACT 1   801  801 ACT ACT A . 
D 3 ACT 1   802  802 ACT ACT A . 
E 4 HOH 1   901  152 HOH HOH A . 
E 4 HOH 2   902  88  HOH HOH A . 
E 4 HOH 3   903  265 HOH HOH A . 
E 4 HOH 4   904  82  HOH HOH A . 
E 4 HOH 5   905  228 HOH HOH A . 
E 4 HOH 6   906  257 HOH HOH A . 
E 4 HOH 7   907  223 HOH HOH A . 
E 4 HOH 8   908  186 HOH HOH A . 
E 4 HOH 9   909  182 HOH HOH A . 
E 4 HOH 10  910  137 HOH HOH A . 
E 4 HOH 11  911  271 HOH HOH A . 
E 4 HOH 12  912  26  HOH HOH A . 
E 4 HOH 13  913  32  HOH HOH A . 
E 4 HOH 14  914  142 HOH HOH A . 
E 4 HOH 15  915  84  HOH HOH A . 
E 4 HOH 16  916  153 HOH HOH A . 
E 4 HOH 17  917  163 HOH HOH A . 
E 4 HOH 18  918  129 HOH HOH A . 
E 4 HOH 19  919  149 HOH HOH A . 
E 4 HOH 20  920  96  HOH HOH A . 
E 4 HOH 21  921  258 HOH HOH A . 
E 4 HOH 22  922  40  HOH HOH A . 
E 4 HOH 23  923  278 HOH HOH A . 
E 4 HOH 24  924  176 HOH HOH A . 
E 4 HOH 25  925  59  HOH HOH A . 
E 4 HOH 26  926  104 HOH HOH A . 
E 4 HOH 27  927  33  HOH HOH A . 
E 4 HOH 28  928  113 HOH HOH A . 
E 4 HOH 29  929  99  HOH HOH A . 
E 4 HOH 30  930  179 HOH HOH A . 
E 4 HOH 31  931  114 HOH HOH A . 
E 4 HOH 32  932  124 HOH HOH A . 
E 4 HOH 33  933  165 HOH HOH A . 
E 4 HOH 34  934  125 HOH HOH A . 
E 4 HOH 35  935  78  HOH HOH A . 
E 4 HOH 36  936  183 HOH HOH A . 
E 4 HOH 37  937  36  HOH HOH A . 
E 4 HOH 38  938  180 HOH HOH A . 
E 4 HOH 39  939  159 HOH HOH A . 
E 4 HOH 40  940  174 HOH HOH A . 
E 4 HOH 41  941  168 HOH HOH A . 
E 4 HOH 42  942  232 HOH HOH A . 
E 4 HOH 43  943  53  HOH HOH A . 
E 4 HOH 44  944  89  HOH HOH A . 
E 4 HOH 45  945  3   HOH HOH A . 
E 4 HOH 46  946  154 HOH HOH A . 
E 4 HOH 47  947  35  HOH HOH A . 
E 4 HOH 48  948  204 HOH HOH A . 
E 4 HOH 49  949  16  HOH HOH A . 
E 4 HOH 50  950  2   HOH HOH A . 
E 4 HOH 51  951  8   HOH HOH A . 
E 4 HOH 52  952  123 HOH HOH A . 
E 4 HOH 53  953  201 HOH HOH A . 
E 4 HOH 54  954  41  HOH HOH A . 
E 4 HOH 55  955  94  HOH HOH A . 
E 4 HOH 56  956  100 HOH HOH A . 
E 4 HOH 57  957  103 HOH HOH A . 
E 4 HOH 58  958  15  HOH HOH A . 
E 4 HOH 59  959  121 HOH HOH A . 
E 4 HOH 60  960  23  HOH HOH A . 
E 4 HOH 61  961  54  HOH HOH A . 
E 4 HOH 62  962  68  HOH HOH A . 
E 4 HOH 63  963  31  HOH HOH A . 
E 4 HOH 64  964  133 HOH HOH A . 
E 4 HOH 65  965  27  HOH HOH A . 
E 4 HOH 66  966  21  HOH HOH A . 
E 4 HOH 67  967  38  HOH HOH A . 
E 4 HOH 68  968  39  HOH HOH A . 
E 4 HOH 69  969  85  HOH HOH A . 
E 4 HOH 70  970  24  HOH HOH A . 
E 4 HOH 71  971  56  HOH HOH A . 
E 4 HOH 72  972  101 HOH HOH A . 
E 4 HOH 73  973  43  HOH HOH A . 
E 4 HOH 74  974  122 HOH HOH A . 
E 4 HOH 75  975  4   HOH HOH A . 
E 4 HOH 76  976  275 HOH HOH A . 
E 4 HOH 77  977  19  HOH HOH A . 
E 4 HOH 78  978  93  HOH HOH A . 
E 4 HOH 79  979  207 HOH HOH A . 
E 4 HOH 80  980  120 HOH HOH A . 
E 4 HOH 81  981  17  HOH HOH A . 
E 4 HOH 82  982  252 HOH HOH A . 
E 4 HOH 83  983  71  HOH HOH A . 
E 4 HOH 84  984  209 HOH HOH A . 
E 4 HOH 85  985  106 HOH HOH A . 
E 4 HOH 86  986  169 HOH HOH A . 
E 4 HOH 87  987  1   HOH HOH A . 
E 4 HOH 88  988  49  HOH HOH A . 
E 4 HOH 89  989  194 HOH HOH A . 
E 4 HOH 90  990  199 HOH HOH A . 
E 4 HOH 91  991  75  HOH HOH A . 
E 4 HOH 92  992  80  HOH HOH A . 
E 4 HOH 93  993  45  HOH HOH A . 
E 4 HOH 94  994  67  HOH HOH A . 
E 4 HOH 95  995  28  HOH HOH A . 
E 4 HOH 96  996  110 HOH HOH A . 
E 4 HOH 97  997  135 HOH HOH A . 
E 4 HOH 98  998  74  HOH HOH A . 
E 4 HOH 99  999  136 HOH HOH A . 
E 4 HOH 100 1000 264 HOH HOH A . 
E 4 HOH 101 1001 57  HOH HOH A . 
E 4 HOH 102 1002 79  HOH HOH A . 
E 4 HOH 103 1003 143 HOH HOH A . 
E 4 HOH 104 1004 61  HOH HOH A . 
E 4 HOH 105 1005 111 HOH HOH A . 
E 4 HOH 106 1006 5   HOH HOH A . 
E 4 HOH 107 1007 119 HOH HOH A . 
E 4 HOH 108 1008 210 HOH HOH A . 
E 4 HOH 109 1009 178 HOH HOH A . 
E 4 HOH 110 1010 65  HOH HOH A . 
E 4 HOH 111 1011 47  HOH HOH A . 
E 4 HOH 112 1012 22  HOH HOH A . 
E 4 HOH 113 1013 116 HOH HOH A . 
E 4 HOH 114 1014 95  HOH HOH A . 
E 4 HOH 115 1015 48  HOH HOH A . 
E 4 HOH 116 1016 128 HOH HOH A . 
E 4 HOH 117 1017 139 HOH HOH A . 
E 4 HOH 118 1018 14  HOH HOH A . 
E 4 HOH 119 1019 25  HOH HOH A . 
E 4 HOH 120 1020 256 HOH HOH A . 
E 4 HOH 121 1021 29  HOH HOH A . 
E 4 HOH 122 1022 138 HOH HOH A . 
E 4 HOH 123 1023 161 HOH HOH A . 
E 4 HOH 124 1024 118 HOH HOH A . 
E 4 HOH 125 1025 155 HOH HOH A . 
E 4 HOH 126 1026 87  HOH HOH A . 
E 4 HOH 127 1027 83  HOH HOH A . 
E 4 HOH 128 1028 34  HOH HOH A . 
E 4 HOH 129 1029 108 HOH HOH A . 
E 4 HOH 130 1030 132 HOH HOH A . 
E 4 HOH 131 1031 227 HOH HOH A . 
E 4 HOH 132 1032 102 HOH HOH A . 
E 4 HOH 133 1033 167 HOH HOH A . 
E 4 HOH 134 1034 10  HOH HOH A . 
E 4 HOH 135 1035 52  HOH HOH A . 
E 4 HOH 136 1036 20  HOH HOH A . 
E 4 HOH 137 1037 156 HOH HOH A . 
E 4 HOH 138 1038 158 HOH HOH A . 
E 4 HOH 139 1039 37  HOH HOH A . 
E 4 HOH 140 1040 98  HOH HOH A . 
E 4 HOH 141 1041 219 HOH HOH A . 
E 4 HOH 142 1042 76  HOH HOH A . 
E 4 HOH 143 1043 69  HOH HOH A . 
E 4 HOH 144 1044 198 HOH HOH A . 
E 4 HOH 145 1045 140 HOH HOH A . 
E 4 HOH 146 1046 262 HOH HOH A . 
E 4 HOH 147 1047 249 HOH HOH A . 
E 4 HOH 148 1048 187 HOH HOH A . 
E 4 HOH 149 1049 90  HOH HOH A . 
E 4 HOH 150 1050 126 HOH HOH A . 
E 4 HOH 151 1051 97  HOH HOH A . 
E 4 HOH 152 1052 170 HOH HOH A . 
E 4 HOH 153 1053 112 HOH HOH A . 
E 4 HOH 154 1054 146 HOH HOH A . 
E 4 HOH 155 1055 268 HOH HOH A . 
E 4 HOH 156 1056 86  HOH HOH A . 
E 4 HOH 157 1057 115 HOH HOH A . 
E 4 HOH 158 1058 267 HOH HOH A . 
E 4 HOH 159 1059 160 HOH HOH A . 
E 4 HOH 160 1060 212 HOH HOH A . 
E 4 HOH 161 1061 44  HOH HOH A . 
E 4 HOH 162 1062 134 HOH HOH A . 
E 4 HOH 163 1063 192 HOH HOH A . 
E 4 HOH 164 1064 263 HOH HOH A . 
E 4 HOH 165 1065 131 HOH HOH A . 
E 4 HOH 166 1066 244 HOH HOH A . 
E 4 HOH 167 1067 64  HOH HOH A . 
E 4 HOH 168 1068 226 HOH HOH A . 
E 4 HOH 169 1069 72  HOH HOH A . 
E 4 HOH 170 1070 73  HOH HOH A . 
E 4 HOH 171 1071 266 HOH HOH A . 
E 4 HOH 172 1072 58  HOH HOH A . 
E 4 HOH 173 1073 63  HOH HOH A . 
E 4 HOH 174 1074 190 HOH HOH A . 
E 4 HOH 175 1075 42  HOH HOH A . 
E 4 HOH 176 1076 184 HOH HOH A . 
E 4 HOH 177 1077 231 HOH HOH A . 
E 4 HOH 178 1078 272 HOH HOH A . 
E 4 HOH 179 1079 109 HOH HOH A . 
E 4 HOH 180 1080 213 HOH HOH A . 
E 4 HOH 181 1081 30  HOH HOH A . 
E 4 HOH 182 1082 214 HOH HOH A . 
E 4 HOH 183 1083 215 HOH HOH A . 
E 4 HOH 184 1084 224 HOH HOH A . 
E 4 HOH 185 1085 280 HOH HOH A . 
E 4 HOH 186 1086 229 HOH HOH A . 
E 4 HOH 187 1087 144 HOH HOH A . 
E 4 HOH 188 1088 269 HOH HOH A . 
E 4 HOH 189 1089 239 HOH HOH A . 
E 4 HOH 190 1090 203 HOH HOH A . 
E 4 HOH 191 1091 218 HOH HOH A . 
E 4 HOH 192 1092 202 HOH HOH A . 
E 4 HOH 193 1093 147 HOH HOH A . 
E 4 HOH 194 1094 175 HOH HOH A . 
E 4 HOH 195 1095 66  HOH HOH A . 
E 4 HOH 196 1096 235 HOH HOH A . 
E 4 HOH 197 1097 248 HOH HOH A . 
E 4 HOH 198 1098 276 HOH HOH A . 
E 4 HOH 199 1099 245 HOH HOH A . 
E 4 HOH 200 1100 230 HOH HOH A . 
E 4 HOH 201 1101 217 HOH HOH A . 
E 4 HOH 202 1102 246 HOH HOH A . 
E 4 HOH 203 1103 261 HOH HOH A . 
E 4 HOH 204 1104 171 HOH HOH A . 
E 4 HOH 205 1105 221 HOH HOH A . 
E 4 HOH 206 1106 205 HOH HOH A . 
E 4 HOH 207 1107 107 HOH HOH A . 
E 4 HOH 208 1108 238 HOH HOH A . 
E 4 HOH 209 1109 240 HOH HOH A . 
E 4 HOH 210 1110 279 HOH HOH A . 
E 4 HOH 211 1111 237 HOH HOH A . 
E 4 HOH 212 1112 260 HOH HOH A . 
E 4 HOH 213 1113 60  HOH HOH A . 
E 4 HOH 214 1114 242 HOH HOH A . 
E 4 HOH 215 1115 130 HOH HOH A . 
E 4 HOH 216 1116 250 HOH HOH A . 
E 4 HOH 217 1117 233 HOH HOH A . 
E 4 HOH 218 1118 191 HOH HOH A . 
E 4 HOH 219 1119 274 HOH HOH A . 
E 4 HOH 220 1120 255 HOH HOH A . 
E 4 HOH 221 1121 196 HOH HOH A . 
E 4 HOH 222 1122 127 HOH HOH A . 
E 4 HOH 223 1123 162 HOH HOH A . 
E 4 HOH 224 1124 206 HOH HOH A . 
E 4 HOH 225 1125 148 HOH HOH A . 
E 4 HOH 226 1126 157 HOH HOH A . 
E 4 HOH 227 1127 105 HOH HOH A . 
E 4 HOH 228 1128 273 HOH HOH A . 
E 4 HOH 229 1129 281 HOH HOH A . 
E 4 HOH 230 1130 189 HOH HOH A . 
E 4 HOH 231 1131 225 HOH HOH A . 
E 4 HOH 232 1132 253 HOH HOH A . 
E 4 HOH 233 1133 247 HOH HOH A . 
E 4 HOH 234 1134 81  HOH HOH A . 
E 4 HOH 235 1135 251 HOH HOH A . 
E 4 HOH 236 1136 236 HOH HOH A . 
E 4 HOH 237 1137 200 HOH HOH A . 
E 4 HOH 238 1138 197 HOH HOH A . 
E 4 HOH 239 1139 208 HOH HOH A . 
E 4 HOH 240 1140 259 HOH HOH A . 
E 4 HOH 241 1141 193 HOH HOH A . 
E 4 HOH 242 1142 166 HOH HOH A . 
E 4 HOH 243 1143 151 HOH HOH A . 
E 4 HOH 244 1144 173 HOH HOH A . 
E 4 HOH 245 1145 243 HOH HOH A . 
F 4 HOH 1   601  91  HOH HOH B . 
F 4 HOH 2   602  270 HOH HOH B . 
F 4 HOH 3   603  6   HOH HOH B . 
F 4 HOH 4   604  18  HOH HOH B . 
F 4 HOH 5   605  11  HOH HOH B . 
F 4 HOH 6   606  145 HOH HOH B . 
F 4 HOH 7   607  7   HOH HOH B . 
F 4 HOH 8   608  70  HOH HOH B . 
F 4 HOH 9   609  62  HOH HOH B . 
F 4 HOH 10  610  150 HOH HOH B . 
F 4 HOH 11  611  117 HOH HOH B . 
F 4 HOH 12  612  13  HOH HOH B . 
F 4 HOH 13  613  12  HOH HOH B . 
F 4 HOH 14  614  141 HOH HOH B . 
F 4 HOH 15  615  277 HOH HOH B . 
F 4 HOH 16  616  241 HOH HOH B . 
F 4 HOH 17  617  46  HOH HOH B . 
F 4 HOH 18  618  220 HOH HOH B . 
F 4 HOH 19  619  50  HOH HOH B . 
F 4 HOH 20  620  164 HOH HOH B . 
F 4 HOH 21  621  188 HOH HOH B . 
F 4 HOH 22  622  177 HOH HOH B . 
F 4 HOH 23  623  185 HOH HOH B . 
F 4 HOH 24  624  234 HOH HOH B . 
F 4 HOH 25  625  222 HOH HOH B . 
F 4 HOH 26  626  254 HOH HOH B . 
F 4 HOH 27  627  282 HOH HOH B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A LEU 188 ? CG  ? A LEU 8   CG  
2  1 Y 1 A LEU 188 ? CD1 ? A LEU 8   CD1 
3  1 Y 1 A LEU 188 ? CD2 ? A LEU 8   CD2 
4  1 Y 1 A LYS 192 ? CE  ? A LYS 12  CE  
5  1 Y 1 A LYS 192 ? NZ  ? A LYS 12  NZ  
6  1 Y 1 A LYS 216 ? CE  ? A LYS 36  CE  
7  1 Y 1 A LYS 216 ? NZ  ? A LYS 36  NZ  
8  1 Y 1 A GLU 217 ? CD  ? A GLU 37  CD  
9  1 Y 1 A GLU 217 ? OE1 ? A GLU 37  OE1 
10 1 Y 1 A GLU 217 ? OE2 ? A GLU 37  OE2 
11 1 Y 1 A LYS 244 ? CG  ? A LYS 64  CG  
12 1 Y 1 A LYS 244 ? CD  ? A LYS 64  CD  
13 1 Y 1 A LYS 244 ? CE  ? A LYS 64  CE  
14 1 Y 1 A LYS 244 ? NZ  ? A LYS 64  NZ  
15 1 Y 1 A LYS 249 ? NZ  ? A LYS 69  NZ  
16 1 Y 1 A GLU 260 ? CD  ? A GLU 80  CD  
17 1 Y 1 A GLU 260 ? OE1 ? A GLU 80  OE1 
18 1 Y 1 A GLU 260 ? OE2 ? A GLU 80  OE2 
19 1 Y 0 A GLU 260 ? CA  B A GLU 80  CA  
20 1 Y 0 A GLU 260 ? CB  B A GLU 80  CB  
21 1 Y 0 A GLU 260 ? CG  B A GLU 80  CG  
22 1 Y 1 A LYS 262 ? NZ  ? A LYS 82  NZ  
23 1 Y 1 A ASN 284 ? CG  ? A ASN 104 CG  
24 1 Y 1 A ASN 284 ? OD1 ? A ASN 104 OD1 
25 1 Y 1 A ASN 284 ? ND2 ? A ASN 104 ND2 
26 1 Y 1 A LYS 332 ? CD  ? A LYS 152 CD  
27 1 Y 1 A LYS 332 ? CE  ? A LYS 152 CE  
28 1 Y 1 A LYS 332 ? NZ  ? A LYS 152 NZ  
29 1 Y 1 A LYS 337 ? CE  ? A LYS 157 CE  
30 1 Y 1 A LYS 337 ? NZ  ? A LYS 157 NZ  
31 1 Y 1 A VAL 338 ? CG1 ? A VAL 158 CG1 
32 1 Y 1 A VAL 338 ? CG2 ? A VAL 158 CG2 
33 1 Y 1 A GLU 348 ? CD  ? A GLU 168 CD  
34 1 Y 1 A GLU 348 ? OE1 ? A GLU 168 OE1 
35 1 Y 1 A GLU 348 ? OE2 ? A GLU 168 OE2 
36 1 Y 1 A GLN 352 ? CG  ? A GLN 172 CG  
37 1 Y 1 A GLN 352 ? CD  ? A GLN 172 CD  
38 1 Y 1 A GLN 352 ? OE1 ? A GLN 172 OE1 
39 1 Y 1 A GLN 352 ? NE2 ? A GLN 172 NE2 
40 1 Y 1 A LYS 359 ? NZ  ? A LYS 179 NZ  
41 1 Y 1 A LYS 402 ? CE  ? A LYS 222 CE  
42 1 Y 1 A LYS 402 ? NZ  ? A LYS 222 NZ  
43 1 Y 1 B GLU 523 ? OE1 ? B GLU 1   OE1 
44 1 Y 1 B GLU 523 ? OE2 ? B GLU 1   OE2 
45 1 Y 1 B ASP 536 ? CG  ? B ASP 14  CG  
46 1 Y 1 B ASP 536 ? OD1 ? B ASP 14  OD1 
47 1 Y 1 B ASP 536 ? OD2 ? B ASP 14  OD2 
48 1 Y 1 B GLU 538 ? CG  ? B GLU 16  CG  
49 1 Y 1 B GLU 538 ? CD  ? B GLU 16  CD  
50 1 Y 1 B GLU 538 ? OE1 ? B GLU 16  OE1 
51 1 Y 1 B GLU 538 ? OE2 ? B GLU 16  OE2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.19.2_4158 1 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.19.2_4158 2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? xia2   ? ? ? .           3 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? d*TREK ? ? ? .           4 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .           5 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8RV1 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     130.760 
_cell.length_a_esd                 ? 
_cell.length_b                     38.120 
_cell.length_b_esd                 ? 
_cell.length_c                     42.400 
_cell.length_c_esd                 ? 
_cell.volume                       211345.819 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8RV1 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                18 
_symmetry.space_group_name_Hall            'P 2 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8RV1 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             1.90 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          35.34 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
'(10-35%) PEG 4K, 0.2 M ammonium acetate and 0.1 M sodium ammonium acetate trihydrate pH (4.1-5.6).' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            297 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2021-12-12 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.9795 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'DIAMOND BEAMLINE I04' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.9795 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   I04 
_diffrn_source.pdbx_synchrotron_site       Diamond 
# 
_reflns.B_iso_Wilson_estimate                          18.54 
_reflns.entry_id                                       8RV1 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.39 
_reflns.d_resolution_low                               43.59 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     43632 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                12.4 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          14.5 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   1 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.39 
_reflns_shell.d_res_low                                     1.41 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2103 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.3 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               23.03 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8RV1 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.39 
_refine.ls_d_res_low                             42.40 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     43568 
_refine.ls_number_reflns_R_free                  2143 
_refine.ls_number_reflns_R_work                  41425 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.83 
_refine.ls_percent_reflns_R_free                 4.92 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1737 
_refine.ls_R_factor_R_free                       0.1914 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1728 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 20.8175 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1734 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.39 
_refine_hist.d_res_low                        42.40 
_refine_hist.number_atoms_solvent             272 
_refine_hist.number_atoms_total               2121 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1841 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         8 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0118 ? 1943 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.3061 ? 2639 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0939 ? 282  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0132 ? 348  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 6.5158 ? 279  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.39 1.42  . . 144 2652 97.76  . . . . 0.3178 . . . . . . . . . . . 0.3547 
'X-RAY DIFFRACTION' 1.42 1.46  . . 151 2719 100.00 . . . . 0.2745 . . . . . . . . . . . 0.3201 
'X-RAY DIFFRACTION' 1.46 1.50  . . 124 2726 100.00 . . . . 0.2388 . . . . . . . . . . . 0.2674 
'X-RAY DIFFRACTION' 1.50 1.54  . . 146 2716 100.00 . . . . 0.2287 . . . . . . . . . . . 0.2647 
'X-RAY DIFFRACTION' 1.54 1.59  . . 138 2733 100.00 . . . . 0.2078 . . . . . . . . . . . 0.2546 
'X-RAY DIFFRACTION' 1.59 1.65  . . 147 2718 100.00 . . . . 0.2021 . . . . . . . . . . . 0.2554 
'X-RAY DIFFRACTION' 1.65 1.71  . . 124 2746 100.00 . . . . 0.1880 . . . . . . . . . . . 0.2366 
'X-RAY DIFFRACTION' 1.71 1.79  . . 155 2749 100.00 . . . . 0.1769 . . . . . . . . . . . 0.2166 
'X-RAY DIFFRACTION' 1.79 1.89  . . 142 2737 100.00 . . . . 0.1651 . . . . . . . . . . . 0.2072 
'X-RAY DIFFRACTION' 1.89 2.00  . . 138 2770 100.00 . . . . 0.1665 . . . . . . . . . . . 0.1816 
'X-RAY DIFFRACTION' 2.00 2.16  . . 137 2765 100.00 . . . . 0.1574 . . . . . . . . . . . 0.2155 
'X-RAY DIFFRACTION' 2.16 2.38  . . 163 2779 99.97  . . . . 0.1608 . . . . . . . . . . . 0.1915 
'X-RAY DIFFRACTION' 2.38 2.72  . . 124 2813 99.90  . . . . 0.1681 . . . . . . . . . . . 0.1703 
'X-RAY DIFFRACTION' 2.72 3.43  . . 150 2817 100.00 . . . . 0.1650 . . . . . . . . . . . 0.1806 
'X-RAY DIFFRACTION' 3.43 42.40 . . 160 2985 99.87  . . . . 0.1613 . . . . . . . . . . . 0.1566 
# 
_struct.entry_id                     8RV1 
_struct.title                        
'HIF prolyl hydroxylase 2 (PHD2) T387S variant bound to acetate (ACT) and hydroxylated Hypoxia-inducible Factor 2alpha (HIF2alpha)' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8RV1 
_struct_keywords.text            '2OG oxygenase, Prolyl hydroxylase, Oxygen sensing, hypoxia, OXIDOREDUCTASE' 
_struct_keywords.pdbx_keywords   OXIDOREDUCTASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 3 ? 
E N N 4 ? 
F N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP EGLN1_HUMAN Q9GZT9 ? 1 
;PNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIE
GKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSG
GILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGE
;
0   
2 UNP EPAS1_HUMAN Q99814 ? 2 ELDLETLAPYIPMDGEDFQL 523 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8RV1 A 1 ? 227 ? Q9GZT9 181 ? 407 ? 181 407 
2 2 8RV1 B 1 ? 20  ? Q99814 523 ? 542 ? 523 542 
# 
_struct_ref_seq_dif.align_id                     1 
_struct_ref_seq_dif.pdbx_pdb_id_code             8RV1 
_struct_ref_seq_dif.mon_id                       SER 
_struct_ref_seq_dif.pdbx_pdb_strand_id           A 
_struct_ref_seq_dif.seq_num                      207 
_struct_ref_seq_dif.pdbx_pdb_ins_code            ? 
_struct_ref_seq_dif.pdbx_seq_db_name             UNP 
_struct_ref_seq_dif.pdbx_seq_db_accession_code   Q9GZT9 
_struct_ref_seq_dif.db_mon_id                    THR 
_struct_ref_seq_dif.pdbx_seq_db_seq_num          387 
_struct_ref_seq_dif.details                      'engineered mutation' 
_struct_ref_seq_dif.pdbx_auth_seq_num            387 
_struct_ref_seq_dif.pdbx_ordinal                 1 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 PRO A 9   ? TYR A 17  ? PRO A 189 TYR A 197 1 ? 9  
HELX_P HELX_P2 AA2 TYR A 17  ? GLY A 26  ? TYR A 197 GLY A 206 1 ? 10 
HELX_P HELX_P3 AA3 GLY A 35  ? THR A 52  ? GLY A 215 THR A 232 1 ? 18 
HELX_P HELX_P4 AA4 SER A 67  ? ILE A 71  ? SER A 247 ILE A 251 5 ? 5  
HELX_P HELX_P5 AA5 CYS A 86  ? CYS A 103 ? CYS A 266 CYS A 283 1 ? 18 
HELX_P HELX_P6 AA6 ASP A 155 ? GLY A 160 ? ASP A 335 GLY A 340 1 ? 6  
HELX_P HELX_P7 AA7 ALA A 213 ? GLY A 226 ? ALA A 393 GLY A 406 1 ? 14 
HELX_P HELX_P8 AA8 ASP B 3   ? ALA B 8   ? ASP B 525 ALA B 530 5 ? 6  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
covale1 covale both ? B ALA 8 C ? ? ? 1_555 B HYP 9  N ? ? B ALA 530 B HYP 531 1_555 ? ? ? ? ? ? ? 1.316 ? ? 
covale2 covale both ? B HYP 9 C ? ? ? 1_555 B TYR 10 N ? ? B HYP 531 B TYR 532 1_555 ? ? ? ? ? ? ? 1.296 ? ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      HYP 
_pdbx_modification_feature.label_asym_id                      B 
_pdbx_modification_feature.label_seq_id                       9 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     . 
_pdbx_modification_feature.modified_residue_label_asym_id     . 
_pdbx_modification_feature.modified_residue_label_seq_id      . 
_pdbx_modification_feature.modified_residue_label_alt_id      . 
_pdbx_modification_feature.auth_comp_id                       HYP 
_pdbx_modification_feature.auth_asym_id                       B 
_pdbx_modification_feature.auth_seq_id                        531 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      . 
_pdbx_modification_feature.modified_residue_auth_asym_id      . 
_pdbx_modification_feature.modified_residue_auth_seq_id       . 
_pdbx_modification_feature.modified_residue_PDB_ins_code      . 
_pdbx_modification_feature.modified_residue_symmetry          . 
_pdbx_modification_feature.comp_id_linking_atom               . 
_pdbx_modification_feature.modified_residue_id_linking_atom   . 
_pdbx_modification_feature.modified_residue_id                PRO 
_pdbx_modification_feature.ref_pcm_id                         1 
_pdbx_modification_feature.ref_comp_id                        HYP 
_pdbx_modification_feature.type                               Hydroxylation 
_pdbx_modification_feature.category                           'Named protein modification' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 6 ? 
AA3 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA2 5 6 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ILE A 27  ? VAL A 30  ? ILE A 207 VAL A 210 
AA1 2 ARG A 182 ? TRP A 187 ? ARG A 362 TRP A 367 
AA1 3 ARG A 142 ? TYR A 149 ? ARG A 322 TYR A 329 
AA1 4 THR A 202 ? ASP A 212 ? THR A 382 ASP A 392 
AA1 5 ALA A 118 ? PRO A 124 ? ALA A 298 PRO A 304 
AA1 6 LYS A 75  ? ILE A 79  ? LYS A 255 ILE A 259 
AA1 7 THR A 56  ? ASP A 57  ? THR A 236 ASP A 237 
AA2 1 ILE A 27  ? VAL A 30  ? ILE A 207 VAL A 210 
AA2 2 ARG A 182 ? TRP A 187 ? ARG A 362 TRP A 367 
AA2 3 ARG A 142 ? TYR A 149 ? ARG A 322 TYR A 329 
AA2 4 THR A 202 ? ASP A 212 ? THR A 382 ASP A 392 
AA2 5 ILE A 112 ? ARG A 115 ? ILE A 292 ARG A 295 
AA2 6 PHE B 18  ? GLN B 19  ? PHE B 540 GLN B 541 
AA3 1 THR A 128 ? HIS A 133 ? THR A 308 HIS A 313 
AA3 2 HIS A 194 ? ALA A 199 ? HIS A 374 ALA A 379 
AA3 3 LEU A 163 ? ILE A 165 ? LEU A 343 ILE A 345 
AA3 4 ALA A 174 ? ILE A 176 ? ALA A 354 ILE A 356 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N VAL A 30  ? N VAL A 210 O LEU A 183 ? O LEU A 363 
AA1 2 3 O PHE A 186 ? O PHE A 366 N THR A 145 ? N THR A 325 
AA1 3 4 N CYS A 143 ? N CYS A 323 O TYR A 210 ? O TYR A 390 
AA1 4 5 O SER A 207 ? O SER A 387 N MET A 119 ? N MET A 299 
AA1 5 6 O VAL A 120 ? O VAL A 300 N THR A 77  ? N THR A 257 
AA1 6 7 O ILE A 76  ? O ILE A 256 N THR A 56  ? N THR A 236 
AA2 1 2 N VAL A 30  ? N VAL A 210 O LEU A 183 ? O LEU A 363 
AA2 2 3 O PHE A 186 ? O PHE A 366 N THR A 145 ? N THR A 325 
AA2 3 4 N CYS A 143 ? N CYS A 323 O TYR A 210 ? O TYR A 390 
AA2 4 5 O PHE A 211 ? O PHE A 391 N GLY A 114 ? N GLY A 294 
AA2 5 6 N ARG A 115 ? N ARG A 295 O PHE B 18  ? O PHE B 540 
AA3 1 2 N THR A 128 ? N THR A 308 O ALA A 199 ? O ALA A 379 
AA3 2 3 O GLU A 195 ? O GLU A 375 N ARG A 164 ? N ARG A 344 
AA3 3 4 N LEU A 163 ? N LEU A 343 O ILE A 176 ? O ILE A 356 
# 
_pdbx_entry_details.entry_id                   8RV1 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 HH22 A ARG 281 ? B O A HOH 902 ? ? 1.58 
2 1 O    B ASP 536 ? ? O B HOH 601 ? ? 2.07 
3 1 O    A HOH 930 ? ? O A HOH 936 ? ? 2.10 
4 1 O    A HOH 903 ? ? O A HOH 906 ? ? 2.13 
5 1 OD1  A ASP 246 ? ? O A HOH 901 ? ? 2.13 
6 1 NH2  A ARG 281 ? B O A HOH 902 ? ? 2.15 
# 
loop_
_pdbx_validate_symm_contact.id 
_pdbx_validate_symm_contact.PDB_model_num 
_pdbx_validate_symm_contact.auth_atom_id_1 
_pdbx_validate_symm_contact.auth_asym_id_1 
_pdbx_validate_symm_contact.auth_comp_id_1 
_pdbx_validate_symm_contact.auth_seq_id_1 
_pdbx_validate_symm_contact.PDB_ins_code_1 
_pdbx_validate_symm_contact.label_alt_id_1 
_pdbx_validate_symm_contact.site_symmetry_1 
_pdbx_validate_symm_contact.auth_atom_id_2 
_pdbx_validate_symm_contact.auth_asym_id_2 
_pdbx_validate_symm_contact.auth_comp_id_2 
_pdbx_validate_symm_contact.auth_seq_id_2 
_pdbx_validate_symm_contact.PDB_ins_code_2 
_pdbx_validate_symm_contact.label_alt_id_2 
_pdbx_validate_symm_contact.site_symmetry_2 
_pdbx_validate_symm_contact.dist 
1 1 OD2 A ASP 224  ? ? 1_555 HH12 A ARG 370 ? ? 1_556 1.59 
2 1 O   A HOH 1080 ? ? 1_555 O    B HOH 610 ? ? 1_545 1.96 
# 
_pdbx_validate_rmsd_angle.id                         1 
_pdbx_validate_rmsd_angle.PDB_model_num              1 
_pdbx_validate_rmsd_angle.auth_atom_id_1             CB 
_pdbx_validate_rmsd_angle.auth_asym_id_1             A 
_pdbx_validate_rmsd_angle.auth_comp_id_1             ASP 
_pdbx_validate_rmsd_angle.auth_seq_id_1              320 
_pdbx_validate_rmsd_angle.PDB_ins_code_1             ? 
_pdbx_validate_rmsd_angle.label_alt_id_1             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_2             CG 
_pdbx_validate_rmsd_angle.auth_asym_id_2             A 
_pdbx_validate_rmsd_angle.auth_comp_id_2             ASP 
_pdbx_validate_rmsd_angle.auth_seq_id_2              320 
_pdbx_validate_rmsd_angle.PDB_ins_code_2             ? 
_pdbx_validate_rmsd_angle.label_alt_id_2             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_3             OD1 
_pdbx_validate_rmsd_angle.auth_asym_id_3             A 
_pdbx_validate_rmsd_angle.auth_comp_id_3             ASP 
_pdbx_validate_rmsd_angle.auth_seq_id_3              320 
_pdbx_validate_rmsd_angle.PDB_ins_code_3             ? 
_pdbx_validate_rmsd_angle.label_alt_id_3             ? 
_pdbx_validate_rmsd_angle.angle_value                124.67 
_pdbx_validate_rmsd_angle.angle_target_value         118.30 
_pdbx_validate_rmsd_angle.angle_deviation            6.37 
_pdbx_validate_rmsd_angle.angle_standard_deviation   0.90 
_pdbx_validate_rmsd_angle.linker_flag                N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 TYR A 197 ? ? -125.93 -58.60  
2 1 LYS A 244 ? ? -128.04 -140.04 
3 1 LEU A 330 ? ? -140.51 32.33   
4 1 PHE A 346 ? ? -114.31 73.71   
5 1 ASP B 539 ? ? 102.64  152.24  
# 
_pdbx_struct_mod_residue.id               1 
_pdbx_struct_mod_residue.label_asym_id    B 
_pdbx_struct_mod_residue.label_comp_id    HYP 
_pdbx_struct_mod_residue.label_seq_id     9 
_pdbx_struct_mod_residue.auth_asym_id     B 
_pdbx_struct_mod_residue.auth_comp_id     HYP 
_pdbx_struct_mod_residue.auth_seq_id      531 
_pdbx_struct_mod_residue.PDB_ins_code     ? 
_pdbx_struct_mod_residue.parent_comp_id   PRO 
_pdbx_struct_mod_residue.details          'modified residue' 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x+1/2,y+1/2,-z 
4 -x,-y,z         
# 
loop_
_pdbx_refine_tls.id 
_pdbx_refine_tls.pdbx_refine_id 
_pdbx_refine_tls.details 
_pdbx_refine_tls.method 
_pdbx_refine_tls.origin_x 
_pdbx_refine_tls.origin_y 
_pdbx_refine_tls.origin_z 
_pdbx_refine_tls.T[1][1] 
_pdbx_refine_tls.T[1][1]_esd 
_pdbx_refine_tls.T[1][2] 
_pdbx_refine_tls.T[1][2]_esd 
_pdbx_refine_tls.T[1][3] 
_pdbx_refine_tls.T[1][3]_esd 
_pdbx_refine_tls.T[2][2] 
_pdbx_refine_tls.T[2][2]_esd 
_pdbx_refine_tls.T[2][3] 
_pdbx_refine_tls.T[2][3]_esd 
_pdbx_refine_tls.T[3][3] 
_pdbx_refine_tls.T[3][3]_esd 
_pdbx_refine_tls.L[1][1] 
_pdbx_refine_tls.L[1][1]_esd 
_pdbx_refine_tls.L[1][2] 
_pdbx_refine_tls.L[1][2]_esd 
_pdbx_refine_tls.L[1][3] 
_pdbx_refine_tls.L[1][3]_esd 
_pdbx_refine_tls.L[2][2] 
_pdbx_refine_tls.L[2][2]_esd 
_pdbx_refine_tls.L[2][3] 
_pdbx_refine_tls.L[2][3]_esd 
_pdbx_refine_tls.L[3][3] 
_pdbx_refine_tls.L[3][3]_esd 
_pdbx_refine_tls.S[1][1] 
_pdbx_refine_tls.S[1][1]_esd 
_pdbx_refine_tls.S[1][2] 
_pdbx_refine_tls.S[1][2]_esd 
_pdbx_refine_tls.S[1][3] 
_pdbx_refine_tls.S[1][3]_esd 
_pdbx_refine_tls.S[2][1] 
_pdbx_refine_tls.S[2][1]_esd 
_pdbx_refine_tls.S[2][2] 
_pdbx_refine_tls.S[2][2]_esd 
_pdbx_refine_tls.S[2][3] 
_pdbx_refine_tls.S[2][3]_esd 
_pdbx_refine_tls.S[3][1] 
_pdbx_refine_tls.S[3][1]_esd 
_pdbx_refine_tls.S[3][2] 
_pdbx_refine_tls.S[3][2]_esd 
_pdbx_refine_tls.S[3][3] 
_pdbx_refine_tls.S[3][3]_esd 
1  'X-RAY DIFFRACTION' ? refined -14.3971036206 -5.71652814913  -9.52082323087 0.132667274925  ? 0.0146594561508  ? 0.025774085613 
? 0.150856145594  ? 0.0441479063038  ? 0.161749256792  ? 1.25747416834 ? -1.04370958266  ? -0.0480585771467 ? 3.09474867573 ? 
1.69563665067   ? 4.3013251354  ? -0.151233660169  ? -0.0985232250371 ? -0.184643597754   ? 0.245419196652   ? 0.0674064560355  ? 
0.0285694935722  ? 0.278985498331   ? 0.353461526423   ? 0.0913852524379   ? 
2  'X-RAY DIFFRACTION' ? refined -18.4966511    12.5845199745   5.81111407406  0.30174685418   ? 0.0452527643056  ? 
0.0652813186752   ? 0.245282959572  ? -0.0260884540114 ? 0.119807801512  ? 1.18460241677 ? -0.059706947974 ? 1.39664853472    ? 
7.7511779755  ? -4.27555944157  ? 4.15053053972 ? -0.100814050472  ? -0.27082757126   ? 0.0593497314999   ? 0.741410933623   ? 
0.206830404025   ? 0.0649772800621  ? 0.0939852564978  ? 0.173550918398   ? -0.15499151547    ? 
3  'X-RAY DIFFRACTION' ? refined -14.8804797493 15.464510866    -8.16955979818 0.0819007361088 ? -0.0179369413714 ? 
0.0237732284833   ? 0.118048128221  ? 0.00234877169086 ? 0.109526568212  ? 2.2673048741  ? -1.72114634105  ? 0.211168567972   ? 
3.19211983127 ? -0.183495494385 ? 1.85360167433 ? -0.0288786281955 ? -0.10011503375   ? 0.111061196656    ? 0.127421570574   ? 
0.0515256366498  ? -0.0551067592853 ? -0.0989341466527 ? 0.0764081584438  ? -0.00205324814762 ? 
4  'X-RAY DIFFRACTION' ? refined -11.449785726  8.1227106097    -13.5184289256 0.138895144251  ? 0.0129876059246  ? 
-0.00565728071433 ? 0.143233790013  ? 0.0473065370835  ? 0.0928694481174 ? 3.52841749334 ? -2.58072065221  ? -1.4350210922    ? 
4.87012927003 ? 2.56271637202   ? 2.23597640427 ? 0.00398598516788 ? -0.0357270479785 ? -0.00243016315679 ? -0.0363212141276 ? 
0.088929838926   ? -0.148258871136  ? -0.0365140861434 ? 0.117377075695   ? -0.127933155957   ? 
5  'X-RAY DIFFRACTION' ? refined -24.6067369414 9.61394005193   -11.1876360267 0.103754507713  ? -0.0186128889767 ? 
0.0115903237164   ? 0.0919789533096 ? -0.0110333227486 ? 0.137166359339  ? 3.56683027607 ? -0.468315113123 ? -1.56459134008   ? 
1.35830440156 ? 0.0513406491706 ? 2.62401220219 ? -0.0273281100475 ? -0.0301372772549 ? -0.0102927774607  ? 0.0858936550251  ? 
0.0105400358679  ? 0.201788831413   ? 0.0578968613734  ? -0.158519359277  ? 0.0120172468582   ? 
6  'X-RAY DIFFRACTION' ? refined -28.607532667  0.0197671230763 -19.6224126916 0.188622520598  ? -0.0101684328144 ? 0.021616593257 
? 0.166899960966  ? -0.012125727324  ? 0.289447213168  ? 5.27274501801 ? 0.926830390287  ? 1.02957386515    ? 4.79014849399 ? 
4.36495632854   ? 3.94925046355 ? 0.0280225340014  ? 0.236599259929   ? -0.733886494547   ? -0.411273186158  ? -0.0710684663665 ? 
-0.108199929578  ? -0.0195930998252 ? -0.254451588394  ? 0.0546992370713   ? 
7  'X-RAY DIFFRACTION' ? refined -21.7078235455 2.31250687596   -9.86413339734 0.140569422235  ? 0.0056353993865  ? 
0.0153926975454   ? 0.115069955801  ? 0.0217276806386  ? 0.16729140039   ? 1.49836283175 ? -0.250270491301 ? 0.33856358604    ? 
1.46572681757 ? 0.313012503232  ? 4.12551160473 ? 0.0175127854926  ? -0.14637035913   ? -0.0721433428287  ? 0.146259667442   ? 
0.0501910025631  ? 0.197333954591   ? 0.106683961244   ? -0.0414071771156 ? -0.0598867673753  ? 
8  'X-RAY DIFFRACTION' ? refined -28.1388123487 8.52229220452   -15.8923051569 0.106281764613  ? 0.0159331047942  ? 
0.0100498263898   ? 0.110421571949  ? 0.0428118059212  ? 0.167492030471  ? 6.76021276446 ? -3.33050899117  ? -5.44283500996   ? 
4.42634983184 ? 5.26915556859   ? 8.76732511604 ? 0.151233525021   ? 0.0893289639981  ? -0.0728464973619  ? -0.167550316927  ? 
-0.174681475638  ? 0.371755975134   ? -0.299633909604  ? -0.224138622305  ? 0.00338824841184  ? 
9  'X-RAY DIFFRACTION' ? refined -10.4003230822 13.6501186463   -18.2890692149 0.100062174401  ? -0.0106054573616 ? 
-0.0125193531631  ? 0.121481042872  ? 0.00709416358963 ? 0.12361144325   ? 5.92092459368 ? 1.24913105216   ? -5.65582158067   ? 
1.01831678933 ? -1.2864620849   ? 7.07486777517 ? -0.0233042402684 ? 0.166129469773   ? 0.185025921636    ? -0.0700872008497 ? 
0.0924226428495  ? -0.0155475334245 ? -0.0680812766572 ? 0.0272809469926  ? -0.0690580979707  ? 
10 'X-RAY DIFFRACTION' ? refined -23.9975516384 16.7072965266   -28.2021990836 0.338656428672  ? -0.0243224240212 ? 
-0.018801471634   ? 0.298742311116  ? 0.014329286726   ? 0.184115857024  ? 6.10713737953 ? -0.367280460086 ? -2.23274678736   ? 
5.08431980386 ? 4.19873947134   ? 4.06951819732 ? -0.0993924316416 ? 1.12946078087    ? -0.14819079005    ? -1.49886108105   ? 
0.16612674379    ? 0.172169491031   ? -0.708793158481  ? -0.599397750702  ? 0.11882404049     ? 
11 'X-RAY DIFFRACTION' ? refined -8.11580229334 16.3858489139   -15.6304847072 0.177077121274  ? -0.0253809600904 ? 
-0.0482356252752  ? 0.215747427082  ? 0.0365180390439  ? 0.291865042379  ? 5.69954298251 ? -2.71975277242  ? 3.80250181004    ? 
1.29723966242 ? -1.84183754106  ? 2.540137877   ? -0.411955138974  ? 0.551584690573   ? 0.892449397534    ? 0.199502841443   ? 
-0.118467184127  ? -0.542474161705  ? -0.338573532824  ? 0.499390978101   ? 0.495454063151    ? 
# 
loop_
_pdbx_refine_tls_group.id 
_pdbx_refine_tls_group.pdbx_refine_id 
_pdbx_refine_tls_group.refine_tls_id 
_pdbx_refine_tls_group.beg_label_asym_id 
_pdbx_refine_tls_group.beg_label_seq_id 
_pdbx_refine_tls_group.beg_auth_asym_id 
_pdbx_refine_tls_group.beg_auth_seq_id 
_pdbx_refine_tls_group.beg_PDB_ins_code 
_pdbx_refine_tls_group.end_label_asym_id 
_pdbx_refine_tls_group.end_label_seq_id 
_pdbx_refine_tls_group.end_auth_asym_id 
_pdbx_refine_tls_group.end_auth_seq_id 
_pdbx_refine_tls_group.end_PDB_ins_code 
_pdbx_refine_tls_group.selection 
_pdbx_refine_tls_group.selection_details 
1  'X-RAY DIFFRACTION' 1  A 1   A 188 ? A 28  A 215 ? ? 
;chain 'A' and (resid 188 through 215 )
;
2  'X-RAY DIFFRACTION' 2  A 29  A 216 ? A 44  A 231 ? ? 
;chain 'A' and (resid 216 through 231 )
;
3  'X-RAY DIFFRACTION' 3  A 45  A 232 ? A 96  A 283 ? ? 
;chain 'A' and (resid 232 through 283 )
;
4  'X-RAY DIFFRACTION' 4  A 97  A 284 ? A 117 A 304 ? ? 
;chain 'A' and (resid 284 through 304 )
;
5  'X-RAY DIFFRACTION' 5  A 118 A 305 ? A 155 A 342 ? ? 
;chain 'A' and (resid 305 through 342 )
;
6  'X-RAY DIFFRACTION' 6  A 156 A 343 ? A 166 A 353 ? ? 
;chain 'A' and (resid 343 through 353 )
;
7  'X-RAY DIFFRACTION' 7  A 167 A 354 ? A 182 A 369 ? ? 
;chain 'A' and (resid 354 through 369 )
;
8  'X-RAY DIFFRACTION' 8  A 183 A 370 ? A 194 A 381 ? ? 
;chain 'A' and (resid 370 through 381 )
;
9  'X-RAY DIFFRACTION' 9  A 195 A 382 ? A 219 A 406 ? ? 
;chain 'A' and (resid 382 through 406 )
;
10 'X-RAY DIFFRACTION' 10 D 1   B 523 ? D 7   B 529 ? ? 
;chain 'B' and (resid 523 through 529 )
;
11 'X-RAY DIFFRACTION' 11 D 8   B 530 ? D 20  B 542 ? ? 
;chain 'B' and (resid 530 through 542 )
;
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      A 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       1145 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   7.13 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A PRO 181 ? A PRO 1   
2 1 Y 1 A ASN 182 ? A ASN 2   
3 1 Y 1 A GLY 183 ? A GLY 3   
4 1 Y 1 A GLN 184 ? A GLN 4   
5 1 Y 1 A THR 185 ? A THR 5   
6 1 Y 1 A LYS 186 ? A LYS 6   
7 1 Y 1 A PRO 187 ? A PRO 7   
8 1 Y 1 A GLU 407 ? A GLU 227 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ACT C    C N N 1   
ACT O    O N N 2   
ACT OXT  O N N 3   
ACT CH3  C N N 4   
ACT H1   H N N 5   
ACT H2   H N N 6   
ACT H3   H N N 7   
ALA N    N N N 8   
ALA CA   C N S 9   
ALA C    C N N 10  
ALA O    O N N 11  
ALA CB   C N N 12  
ALA OXT  O N N 13  
ALA H    H N N 14  
ALA H2   H N N 15  
ALA HA   H N N 16  
ALA HB1  H N N 17  
ALA HB2  H N N 18  
ALA HB3  H N N 19  
ALA HXT  H N N 20  
ARG N    N N N 21  
ARG CA   C N S 22  
ARG C    C N N 23  
ARG O    O N N 24  
ARG CB   C N N 25  
ARG CG   C N N 26  
ARG CD   C N N 27  
ARG NE   N N N 28  
ARG CZ   C N N 29  
ARG NH1  N N N 30  
ARG NH2  N N N 31  
ARG OXT  O N N 32  
ARG H    H N N 33  
ARG H2   H N N 34  
ARG HA   H N N 35  
ARG HB2  H N N 36  
ARG HB3  H N N 37  
ARG HG2  H N N 38  
ARG HG3  H N N 39  
ARG HD2  H N N 40  
ARG HD3  H N N 41  
ARG HE   H N N 42  
ARG HH11 H N N 43  
ARG HH12 H N N 44  
ARG HH21 H N N 45  
ARG HH22 H N N 46  
ARG HXT  H N N 47  
ASN N    N N N 48  
ASN CA   C N S 49  
ASN C    C N N 50  
ASN O    O N N 51  
ASN CB   C N N 52  
ASN CG   C N N 53  
ASN OD1  O N N 54  
ASN ND2  N N N 55  
ASN OXT  O N N 56  
ASN H    H N N 57  
ASN H2   H N N 58  
ASN HA   H N N 59  
ASN HB2  H N N 60  
ASN HB3  H N N 61  
ASN HD21 H N N 62  
ASN HD22 H N N 63  
ASN HXT  H N N 64  
ASP N    N N N 65  
ASP CA   C N S 66  
ASP C    C N N 67  
ASP O    O N N 68  
ASP CB   C N N 69  
ASP CG   C N N 70  
ASP OD1  O N N 71  
ASP OD2  O N N 72  
ASP OXT  O N N 73  
ASP H    H N N 74  
ASP H2   H N N 75  
ASP HA   H N N 76  
ASP HB2  H N N 77  
ASP HB3  H N N 78  
ASP HD2  H N N 79  
ASP HXT  H N N 80  
CYS N    N N N 81  
CYS CA   C N R 82  
CYS C    C N N 83  
CYS O    O N N 84  
CYS CB   C N N 85  
CYS SG   S N N 86  
CYS OXT  O N N 87  
CYS H    H N N 88  
CYS H2   H N N 89  
CYS HA   H N N 90  
CYS HB2  H N N 91  
CYS HB3  H N N 92  
CYS HG   H N N 93  
CYS HXT  H N N 94  
GLN N    N N N 95  
GLN CA   C N S 96  
GLN C    C N N 97  
GLN O    O N N 98  
GLN CB   C N N 99  
GLN CG   C N N 100 
GLN CD   C N N 101 
GLN OE1  O N N 102 
GLN NE2  N N N 103 
GLN OXT  O N N 104 
GLN H    H N N 105 
GLN H2   H N N 106 
GLN HA   H N N 107 
GLN HB2  H N N 108 
GLN HB3  H N N 109 
GLN HG2  H N N 110 
GLN HG3  H N N 111 
GLN HE21 H N N 112 
GLN HE22 H N N 113 
GLN HXT  H N N 114 
GLU N    N N N 115 
GLU CA   C N S 116 
GLU C    C N N 117 
GLU O    O N N 118 
GLU CB   C N N 119 
GLU CG   C N N 120 
GLU CD   C N N 121 
GLU OE1  O N N 122 
GLU OE2  O N N 123 
GLU OXT  O N N 124 
GLU H    H N N 125 
GLU H2   H N N 126 
GLU HA   H N N 127 
GLU HB2  H N N 128 
GLU HB3  H N N 129 
GLU HG2  H N N 130 
GLU HG3  H N N 131 
GLU HE2  H N N 132 
GLU HXT  H N N 133 
GLY N    N N N 134 
GLY CA   C N N 135 
GLY C    C N N 136 
GLY O    O N N 137 
GLY OXT  O N N 138 
GLY H    H N N 139 
GLY H2   H N N 140 
GLY HA2  H N N 141 
GLY HA3  H N N 142 
GLY HXT  H N N 143 
HIS N    N N N 144 
HIS CA   C N S 145 
HIS C    C N N 146 
HIS O    O N N 147 
HIS CB   C N N 148 
HIS CG   C Y N 149 
HIS ND1  N Y N 150 
HIS CD2  C Y N 151 
HIS CE1  C Y N 152 
HIS NE2  N Y N 153 
HIS OXT  O N N 154 
HIS H    H N N 155 
HIS H2   H N N 156 
HIS HA   H N N 157 
HIS HB2  H N N 158 
HIS HB3  H N N 159 
HIS HD1  H N N 160 
HIS HD2  H N N 161 
HIS HE1  H N N 162 
HIS HE2  H N N 163 
HIS HXT  H N N 164 
HOH O    O N N 165 
HOH H1   H N N 166 
HOH H2   H N N 167 
HYP N    N N N 168 
HYP CA   C N S 169 
HYP C    C N N 170 
HYP O    O N N 171 
HYP CB   C N N 172 
HYP CG   C N R 173 
HYP CD   C N N 174 
HYP OD1  O N N 175 
HYP OXT  O N N 176 
HYP H    H N N 177 
HYP HA   H N N 178 
HYP HB2  H N N 179 
HYP HB3  H N N 180 
HYP HG   H N N 181 
HYP HD22 H N N 182 
HYP HD23 H N N 183 
HYP HD1  H N N 184 
HYP HXT  H N N 185 
ILE N    N N N 186 
ILE CA   C N S 187 
ILE C    C N N 188 
ILE O    O N N 189 
ILE CB   C N S 190 
ILE CG1  C N N 191 
ILE CG2  C N N 192 
ILE CD1  C N N 193 
ILE OXT  O N N 194 
ILE H    H N N 195 
ILE H2   H N N 196 
ILE HA   H N N 197 
ILE HB   H N N 198 
ILE HG12 H N N 199 
ILE HG13 H N N 200 
ILE HG21 H N N 201 
ILE HG22 H N N 202 
ILE HG23 H N N 203 
ILE HD11 H N N 204 
ILE HD12 H N N 205 
ILE HD13 H N N 206 
ILE HXT  H N N 207 
LEU N    N N N 208 
LEU CA   C N S 209 
LEU C    C N N 210 
LEU O    O N N 211 
LEU CB   C N N 212 
LEU CG   C N N 213 
LEU CD1  C N N 214 
LEU CD2  C N N 215 
LEU OXT  O N N 216 
LEU H    H N N 217 
LEU H2   H N N 218 
LEU HA   H N N 219 
LEU HB2  H N N 220 
LEU HB3  H N N 221 
LEU HG   H N N 222 
LEU HD11 H N N 223 
LEU HD12 H N N 224 
LEU HD13 H N N 225 
LEU HD21 H N N 226 
LEU HD22 H N N 227 
LEU HD23 H N N 228 
LEU HXT  H N N 229 
LYS N    N N N 230 
LYS CA   C N S 231 
LYS C    C N N 232 
LYS O    O N N 233 
LYS CB   C N N 234 
LYS CG   C N N 235 
LYS CD   C N N 236 
LYS CE   C N N 237 
LYS NZ   N N N 238 
LYS OXT  O N N 239 
LYS H    H N N 240 
LYS H2   H N N 241 
LYS HA   H N N 242 
LYS HB2  H N N 243 
LYS HB3  H N N 244 
LYS HG2  H N N 245 
LYS HG3  H N N 246 
LYS HD2  H N N 247 
LYS HD3  H N N 248 
LYS HE2  H N N 249 
LYS HE3  H N N 250 
LYS HZ1  H N N 251 
LYS HZ2  H N N 252 
LYS HZ3  H N N 253 
LYS HXT  H N N 254 
MET N    N N N 255 
MET CA   C N S 256 
MET C    C N N 257 
MET O    O N N 258 
MET CB   C N N 259 
MET CG   C N N 260 
MET SD   S N N 261 
MET CE   C N N 262 
MET OXT  O N N 263 
MET H    H N N 264 
MET H2   H N N 265 
MET HA   H N N 266 
MET HB2  H N N 267 
MET HB3  H N N 268 
MET HG2  H N N 269 
MET HG3  H N N 270 
MET HE1  H N N 271 
MET HE2  H N N 272 
MET HE3  H N N 273 
MET HXT  H N N 274 
PHE N    N N N 275 
PHE CA   C N S 276 
PHE C    C N N 277 
PHE O    O N N 278 
PHE CB   C N N 279 
PHE CG   C Y N 280 
PHE CD1  C Y N 281 
PHE CD2  C Y N 282 
PHE CE1  C Y N 283 
PHE CE2  C Y N 284 
PHE CZ   C Y N 285 
PHE OXT  O N N 286 
PHE H    H N N 287 
PHE H2   H N N 288 
PHE HA   H N N 289 
PHE HB2  H N N 290 
PHE HB3  H N N 291 
PHE HD1  H N N 292 
PHE HD2  H N N 293 
PHE HE1  H N N 294 
PHE HE2  H N N 295 
PHE HZ   H N N 296 
PHE HXT  H N N 297 
PRO N    N N N 298 
PRO CA   C N S 299 
PRO C    C N N 300 
PRO O    O N N 301 
PRO CB   C N N 302 
PRO CG   C N N 303 
PRO CD   C N N 304 
PRO OXT  O N N 305 
PRO H    H N N 306 
PRO HA   H N N 307 
PRO HB2  H N N 308 
PRO HB3  H N N 309 
PRO HG2  H N N 310 
PRO HG3  H N N 311 
PRO HD2  H N N 312 
PRO HD3  H N N 313 
PRO HXT  H N N 314 
SER N    N N N 315 
SER CA   C N S 316 
SER C    C N N 317 
SER O    O N N 318 
SER CB   C N N 319 
SER OG   O N N 320 
SER OXT  O N N 321 
SER H    H N N 322 
SER H2   H N N 323 
SER HA   H N N 324 
SER HB2  H N N 325 
SER HB3  H N N 326 
SER HG   H N N 327 
SER HXT  H N N 328 
THR N    N N N 329 
THR CA   C N S 330 
THR C    C N N 331 
THR O    O N N 332 
THR CB   C N R 333 
THR OG1  O N N 334 
THR CG2  C N N 335 
THR OXT  O N N 336 
THR H    H N N 337 
THR H2   H N N 338 
THR HA   H N N 339 
THR HB   H N N 340 
THR HG1  H N N 341 
THR HG21 H N N 342 
THR HG22 H N N 343 
THR HG23 H N N 344 
THR HXT  H N N 345 
TRP N    N N N 346 
TRP CA   C N S 347 
TRP C    C N N 348 
TRP O    O N N 349 
TRP CB   C N N 350 
TRP CG   C Y N 351 
TRP CD1  C Y N 352 
TRP CD2  C Y N 353 
TRP NE1  N Y N 354 
TRP CE2  C Y N 355 
TRP CE3  C Y N 356 
TRP CZ2  C Y N 357 
TRP CZ3  C Y N 358 
TRP CH2  C Y N 359 
TRP OXT  O N N 360 
TRP H    H N N 361 
TRP H2   H N N 362 
TRP HA   H N N 363 
TRP HB2  H N N 364 
TRP HB3  H N N 365 
TRP HD1  H N N 366 
TRP HE1  H N N 367 
TRP HE3  H N N 368 
TRP HZ2  H N N 369 
TRP HZ3  H N N 370 
TRP HH2  H N N 371 
TRP HXT  H N N 372 
TYR N    N N N 373 
TYR CA   C N S 374 
TYR C    C N N 375 
TYR O    O N N 376 
TYR CB   C N N 377 
TYR CG   C Y N 378 
TYR CD1  C Y N 379 
TYR CD2  C Y N 380 
TYR CE1  C Y N 381 
TYR CE2  C Y N 382 
TYR CZ   C Y N 383 
TYR OH   O N N 384 
TYR OXT  O N N 385 
TYR H    H N N 386 
TYR H2   H N N 387 
TYR HA   H N N 388 
TYR HB2  H N N 389 
TYR HB3  H N N 390 
TYR HD1  H N N 391 
TYR HD2  H N N 392 
TYR HE1  H N N 393 
TYR HE2  H N N 394 
TYR HH   H N N 395 
TYR HXT  H N N 396 
VAL N    N N N 397 
VAL CA   C N S 398 
VAL C    C N N 399 
VAL O    O N N 400 
VAL CB   C N N 401 
VAL CG1  C N N 402 
VAL CG2  C N N 403 
VAL OXT  O N N 404 
VAL H    H N N 405 
VAL H2   H N N 406 
VAL HA   H N N 407 
VAL HB   H N N 408 
VAL HG11 H N N 409 
VAL HG12 H N N 410 
VAL HG13 H N N 411 
VAL HG21 H N N 412 
VAL HG22 H N N 413 
VAL HG23 H N N 414 
VAL HXT  H N N 415 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ACT C   O    doub N N 1   
ACT C   OXT  sing N N 2   
ACT C   CH3  sing N N 3   
ACT CH3 H1   sing N N 4   
ACT CH3 H2   sing N N 5   
ACT CH3 H3   sing N N 6   
ALA N   CA   sing N N 7   
ALA N   H    sing N N 8   
ALA N   H2   sing N N 9   
ALA CA  C    sing N N 10  
ALA CA  CB   sing N N 11  
ALA CA  HA   sing N N 12  
ALA C   O    doub N N 13  
ALA C   OXT  sing N N 14  
ALA CB  HB1  sing N N 15  
ALA CB  HB2  sing N N 16  
ALA CB  HB3  sing N N 17  
ALA OXT HXT  sing N N 18  
ARG N   CA   sing N N 19  
ARG N   H    sing N N 20  
ARG N   H2   sing N N 21  
ARG CA  C    sing N N 22  
ARG CA  CB   sing N N 23  
ARG CA  HA   sing N N 24  
ARG C   O    doub N N 25  
ARG C   OXT  sing N N 26  
ARG CB  CG   sing N N 27  
ARG CB  HB2  sing N N 28  
ARG CB  HB3  sing N N 29  
ARG CG  CD   sing N N 30  
ARG CG  HG2  sing N N 31  
ARG CG  HG3  sing N N 32  
ARG CD  NE   sing N N 33  
ARG CD  HD2  sing N N 34  
ARG CD  HD3  sing N N 35  
ARG NE  CZ   sing N N 36  
ARG NE  HE   sing N N 37  
ARG CZ  NH1  sing N N 38  
ARG CZ  NH2  doub N N 39  
ARG NH1 HH11 sing N N 40  
ARG NH1 HH12 sing N N 41  
ARG NH2 HH21 sing N N 42  
ARG NH2 HH22 sing N N 43  
ARG OXT HXT  sing N N 44  
ASN N   CA   sing N N 45  
ASN N   H    sing N N 46  
ASN N   H2   sing N N 47  
ASN CA  C    sing N N 48  
ASN CA  CB   sing N N 49  
ASN CA  HA   sing N N 50  
ASN C   O    doub N N 51  
ASN C   OXT  sing N N 52  
ASN CB  CG   sing N N 53  
ASN CB  HB2  sing N N 54  
ASN CB  HB3  sing N N 55  
ASN CG  OD1  doub N N 56  
ASN CG  ND2  sing N N 57  
ASN ND2 HD21 sing N N 58  
ASN ND2 HD22 sing N N 59  
ASN OXT HXT  sing N N 60  
ASP N   CA   sing N N 61  
ASP N   H    sing N N 62  
ASP N   H2   sing N N 63  
ASP CA  C    sing N N 64  
ASP CA  CB   sing N N 65  
ASP CA  HA   sing N N 66  
ASP C   O    doub N N 67  
ASP C   OXT  sing N N 68  
ASP CB  CG   sing N N 69  
ASP CB  HB2  sing N N 70  
ASP CB  HB3  sing N N 71  
ASP CG  OD1  doub N N 72  
ASP CG  OD2  sing N N 73  
ASP OD2 HD2  sing N N 74  
ASP OXT HXT  sing N N 75  
CYS N   CA   sing N N 76  
CYS N   H    sing N N 77  
CYS N   H2   sing N N 78  
CYS CA  C    sing N N 79  
CYS CA  CB   sing N N 80  
CYS CA  HA   sing N N 81  
CYS C   O    doub N N 82  
CYS C   OXT  sing N N 83  
CYS CB  SG   sing N N 84  
CYS CB  HB2  sing N N 85  
CYS CB  HB3  sing N N 86  
CYS SG  HG   sing N N 87  
CYS OXT HXT  sing N N 88  
GLN N   CA   sing N N 89  
GLN N   H    sing N N 90  
GLN N   H2   sing N N 91  
GLN CA  C    sing N N 92  
GLN CA  CB   sing N N 93  
GLN CA  HA   sing N N 94  
GLN C   O    doub N N 95  
GLN C   OXT  sing N N 96  
GLN CB  CG   sing N N 97  
GLN CB  HB2  sing N N 98  
GLN CB  HB3  sing N N 99  
GLN CG  CD   sing N N 100 
GLN CG  HG2  sing N N 101 
GLN CG  HG3  sing N N 102 
GLN CD  OE1  doub N N 103 
GLN CD  NE2  sing N N 104 
GLN NE2 HE21 sing N N 105 
GLN NE2 HE22 sing N N 106 
GLN OXT HXT  sing N N 107 
GLU N   CA   sing N N 108 
GLU N   H    sing N N 109 
GLU N   H2   sing N N 110 
GLU CA  C    sing N N 111 
GLU CA  CB   sing N N 112 
GLU CA  HA   sing N N 113 
GLU C   O    doub N N 114 
GLU C   OXT  sing N N 115 
GLU CB  CG   sing N N 116 
GLU CB  HB2  sing N N 117 
GLU CB  HB3  sing N N 118 
GLU CG  CD   sing N N 119 
GLU CG  HG2  sing N N 120 
GLU CG  HG3  sing N N 121 
GLU CD  OE1  doub N N 122 
GLU CD  OE2  sing N N 123 
GLU OE2 HE2  sing N N 124 
GLU OXT HXT  sing N N 125 
GLY N   CA   sing N N 126 
GLY N   H    sing N N 127 
GLY N   H2   sing N N 128 
GLY CA  C    sing N N 129 
GLY CA  HA2  sing N N 130 
GLY CA  HA3  sing N N 131 
GLY C   O    doub N N 132 
GLY C   OXT  sing N N 133 
GLY OXT HXT  sing N N 134 
HIS N   CA   sing N N 135 
HIS N   H    sing N N 136 
HIS N   H2   sing N N 137 
HIS CA  C    sing N N 138 
HIS CA  CB   sing N N 139 
HIS CA  HA   sing N N 140 
HIS C   O    doub N N 141 
HIS C   OXT  sing N N 142 
HIS CB  CG   sing N N 143 
HIS CB  HB2  sing N N 144 
HIS CB  HB3  sing N N 145 
HIS CG  ND1  sing Y N 146 
HIS CG  CD2  doub Y N 147 
HIS ND1 CE1  doub Y N 148 
HIS ND1 HD1  sing N N 149 
HIS CD2 NE2  sing Y N 150 
HIS CD2 HD2  sing N N 151 
HIS CE1 NE2  sing Y N 152 
HIS CE1 HE1  sing N N 153 
HIS NE2 HE2  sing N N 154 
HIS OXT HXT  sing N N 155 
HOH O   H1   sing N N 156 
HOH O   H2   sing N N 157 
HYP N   CA   sing N N 158 
HYP N   CD   sing N N 159 
HYP N   H    sing N N 160 
HYP CA  C    sing N N 161 
HYP CA  CB   sing N N 162 
HYP CA  HA   sing N N 163 
HYP C   O    doub N N 164 
HYP C   OXT  sing N N 165 
HYP CB  CG   sing N N 166 
HYP CB  HB2  sing N N 167 
HYP CB  HB3  sing N N 168 
HYP CG  CD   sing N N 169 
HYP CG  OD1  sing N N 170 
HYP CG  HG   sing N N 171 
HYP CD  HD22 sing N N 172 
HYP CD  HD23 sing N N 173 
HYP OD1 HD1  sing N N 174 
HYP OXT HXT  sing N N 175 
ILE N   CA   sing N N 176 
ILE N   H    sing N N 177 
ILE N   H2   sing N N 178 
ILE CA  C    sing N N 179 
ILE CA  CB   sing N N 180 
ILE CA  HA   sing N N 181 
ILE C   O    doub N N 182 
ILE C   OXT  sing N N 183 
ILE CB  CG1  sing N N 184 
ILE CB  CG2  sing N N 185 
ILE CB  HB   sing N N 186 
ILE CG1 CD1  sing N N 187 
ILE CG1 HG12 sing N N 188 
ILE CG1 HG13 sing N N 189 
ILE CG2 HG21 sing N N 190 
ILE CG2 HG22 sing N N 191 
ILE CG2 HG23 sing N N 192 
ILE CD1 HD11 sing N N 193 
ILE CD1 HD12 sing N N 194 
ILE CD1 HD13 sing N N 195 
ILE OXT HXT  sing N N 196 
LEU N   CA   sing N N 197 
LEU N   H    sing N N 198 
LEU N   H2   sing N N 199 
LEU CA  C    sing N N 200 
LEU CA  CB   sing N N 201 
LEU CA  HA   sing N N 202 
LEU C   O    doub N N 203 
LEU C   OXT  sing N N 204 
LEU CB  CG   sing N N 205 
LEU CB  HB2  sing N N 206 
LEU CB  HB3  sing N N 207 
LEU CG  CD1  sing N N 208 
LEU CG  CD2  sing N N 209 
LEU CG  HG   sing N N 210 
LEU CD1 HD11 sing N N 211 
LEU CD1 HD12 sing N N 212 
LEU CD1 HD13 sing N N 213 
LEU CD2 HD21 sing N N 214 
LEU CD2 HD22 sing N N 215 
LEU CD2 HD23 sing N N 216 
LEU OXT HXT  sing N N 217 
LYS N   CA   sing N N 218 
LYS N   H    sing N N 219 
LYS N   H2   sing N N 220 
LYS CA  C    sing N N 221 
LYS CA  CB   sing N N 222 
LYS CA  HA   sing N N 223 
LYS C   O    doub N N 224 
LYS C   OXT  sing N N 225 
LYS CB  CG   sing N N 226 
LYS CB  HB2  sing N N 227 
LYS CB  HB3  sing N N 228 
LYS CG  CD   sing N N 229 
LYS CG  HG2  sing N N 230 
LYS CG  HG3  sing N N 231 
LYS CD  CE   sing N N 232 
LYS CD  HD2  sing N N 233 
LYS CD  HD3  sing N N 234 
LYS CE  NZ   sing N N 235 
LYS CE  HE2  sing N N 236 
LYS CE  HE3  sing N N 237 
LYS NZ  HZ1  sing N N 238 
LYS NZ  HZ2  sing N N 239 
LYS NZ  HZ3  sing N N 240 
LYS OXT HXT  sing N N 241 
MET N   CA   sing N N 242 
MET N   H    sing N N 243 
MET N   H2   sing N N 244 
MET CA  C    sing N N 245 
MET CA  CB   sing N N 246 
MET CA  HA   sing N N 247 
MET C   O    doub N N 248 
MET C   OXT  sing N N 249 
MET CB  CG   sing N N 250 
MET CB  HB2  sing N N 251 
MET CB  HB3  sing N N 252 
MET CG  SD   sing N N 253 
MET CG  HG2  sing N N 254 
MET CG  HG3  sing N N 255 
MET SD  CE   sing N N 256 
MET CE  HE1  sing N N 257 
MET CE  HE2  sing N N 258 
MET CE  HE3  sing N N 259 
MET OXT HXT  sing N N 260 
PHE N   CA   sing N N 261 
PHE N   H    sing N N 262 
PHE N   H2   sing N N 263 
PHE CA  C    sing N N 264 
PHE CA  CB   sing N N 265 
PHE CA  HA   sing N N 266 
PHE C   O    doub N N 267 
PHE C   OXT  sing N N 268 
PHE CB  CG   sing N N 269 
PHE CB  HB2  sing N N 270 
PHE CB  HB3  sing N N 271 
PHE CG  CD1  doub Y N 272 
PHE CG  CD2  sing Y N 273 
PHE CD1 CE1  sing Y N 274 
PHE CD1 HD1  sing N N 275 
PHE CD2 CE2  doub Y N 276 
PHE CD2 HD2  sing N N 277 
PHE CE1 CZ   doub Y N 278 
PHE CE1 HE1  sing N N 279 
PHE CE2 CZ   sing Y N 280 
PHE CE2 HE2  sing N N 281 
PHE CZ  HZ   sing N N 282 
PHE OXT HXT  sing N N 283 
PRO N   CA   sing N N 284 
PRO N   CD   sing N N 285 
PRO N   H    sing N N 286 
PRO CA  C    sing N N 287 
PRO CA  CB   sing N N 288 
PRO CA  HA   sing N N 289 
PRO C   O    doub N N 290 
PRO C   OXT  sing N N 291 
PRO CB  CG   sing N N 292 
PRO CB  HB2  sing N N 293 
PRO CB  HB3  sing N N 294 
PRO CG  CD   sing N N 295 
PRO CG  HG2  sing N N 296 
PRO CG  HG3  sing N N 297 
PRO CD  HD2  sing N N 298 
PRO CD  HD3  sing N N 299 
PRO OXT HXT  sing N N 300 
SER N   CA   sing N N 301 
SER N   H    sing N N 302 
SER N   H2   sing N N 303 
SER CA  C    sing N N 304 
SER CA  CB   sing N N 305 
SER CA  HA   sing N N 306 
SER C   O    doub N N 307 
SER C   OXT  sing N N 308 
SER CB  OG   sing N N 309 
SER CB  HB2  sing N N 310 
SER CB  HB3  sing N N 311 
SER OG  HG   sing N N 312 
SER OXT HXT  sing N N 313 
THR N   CA   sing N N 314 
THR N   H    sing N N 315 
THR N   H2   sing N N 316 
THR CA  C    sing N N 317 
THR CA  CB   sing N N 318 
THR CA  HA   sing N N 319 
THR C   O    doub N N 320 
THR C   OXT  sing N N 321 
THR CB  OG1  sing N N 322 
THR CB  CG2  sing N N 323 
THR CB  HB   sing N N 324 
THR OG1 HG1  sing N N 325 
THR CG2 HG21 sing N N 326 
THR CG2 HG22 sing N N 327 
THR CG2 HG23 sing N N 328 
THR OXT HXT  sing N N 329 
TRP N   CA   sing N N 330 
TRP N   H    sing N N 331 
TRP N   H2   sing N N 332 
TRP CA  C    sing N N 333 
TRP CA  CB   sing N N 334 
TRP CA  HA   sing N N 335 
TRP C   O    doub N N 336 
TRP C   OXT  sing N N 337 
TRP CB  CG   sing N N 338 
TRP CB  HB2  sing N N 339 
TRP CB  HB3  sing N N 340 
TRP CG  CD1  doub Y N 341 
TRP CG  CD2  sing Y N 342 
TRP CD1 NE1  sing Y N 343 
TRP CD1 HD1  sing N N 344 
TRP CD2 CE2  doub Y N 345 
TRP CD2 CE3  sing Y N 346 
TRP NE1 CE2  sing Y N 347 
TRP NE1 HE1  sing N N 348 
TRP CE2 CZ2  sing Y N 349 
TRP CE3 CZ3  doub Y N 350 
TRP CE3 HE3  sing N N 351 
TRP CZ2 CH2  doub Y N 352 
TRP CZ2 HZ2  sing N N 353 
TRP CZ3 CH2  sing Y N 354 
TRP CZ3 HZ3  sing N N 355 
TRP CH2 HH2  sing N N 356 
TRP OXT HXT  sing N N 357 
TYR N   CA   sing N N 358 
TYR N   H    sing N N 359 
TYR N   H2   sing N N 360 
TYR CA  C    sing N N 361 
TYR CA  CB   sing N N 362 
TYR CA  HA   sing N N 363 
TYR C   O    doub N N 364 
TYR C   OXT  sing N N 365 
TYR CB  CG   sing N N 366 
TYR CB  HB2  sing N N 367 
TYR CB  HB3  sing N N 368 
TYR CG  CD1  doub Y N 369 
TYR CG  CD2  sing Y N 370 
TYR CD1 CE1  sing Y N 371 
TYR CD1 HD1  sing N N 372 
TYR CD2 CE2  doub Y N 373 
TYR CD2 HD2  sing N N 374 
TYR CE1 CZ   doub Y N 375 
TYR CE1 HE1  sing N N 376 
TYR CE2 CZ   sing Y N 377 
TYR CE2 HE2  sing N N 378 
TYR CZ  OH   sing N N 379 
TYR OH  HH   sing N N 380 
TYR OXT HXT  sing N N 381 
VAL N   CA   sing N N 382 
VAL N   H    sing N N 383 
VAL N   H2   sing N N 384 
VAL CA  C    sing N N 385 
VAL CA  CB   sing N N 386 
VAL CA  HA   sing N N 387 
VAL C   O    doub N N 388 
VAL C   OXT  sing N N 389 
VAL CB  CG1  sing N N 390 
VAL CB  CG2  sing N N 391 
VAL CB  HB   sing N N 392 
VAL CG1 HG11 sing N N 393 
VAL CG1 HG12 sing N N 394 
VAL CG1 HG13 sing N N 395 
VAL CG2 HG21 sing N N 396 
VAL CG2 HG22 sing N N 397 
VAL CG2 HG23 sing N N 398 
VAL OXT HXT  sing N N 399 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Biotechnology and Biological Sciences Research Council (BBSRC)' 'United Kingdom' 'BB/R013829/1, BB/J001694/2, BB/L000121/1' 1 
'Cancer Research UK'                                             'United Kingdom' C8717/A18245                               2 
'Wellcome Trust'                                                 'United Kingdom' 091857/7/10/7                              3 
'Other government'                                               ?                'Newton Abraham Scholarship'               4 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      Other 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          'PHD2 bound to hydroxylated HIF' 
# 
_space_group.name_H-M_alt     'P 21 21 2' 
_space_group.name_Hall        'P 2 2ab' 
_space_group.IT_number        18 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8RV1 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.007648 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.026233 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.023585 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N    . LEU A 1 8   ? -10.72716 -4.49048  0.93257   1.000 31.73358 ? 188  LEU A N    1 
ATOM   2    C CA   . LEU A 1 8   ? -10.30145 -5.85068  0.57783   1.000 39.55883 ? 188  LEU A CA   1 
ATOM   3    C C    . LEU A 1 8   ? -9.00877  -5.75347  -0.23018  1.000 27.73636 ? 188  LEU A C    1 
ATOM   4    O O    . LEU A 1 8   ? -8.72363  -4.71961  -0.84567  1.000 29.98159 ? 188  LEU A O    1 
ATOM   5    C CB   . LEU A 1 8   ? -11.39119 -6.56115  -0.21939  1.000 36.11509 ? 188  LEU A CB   1 
ATOM   6    H H    . LEU A 1 8   ? -11.16907 -4.08991  0.31013   1.000 38.08030 ? 188  LEU A H    1 
ATOM   7    H HA   . LEU A 1 8   ? -10.14527 -6.38598  1.37153   1.000 47.47060 ? 188  LEU A HA   1 
ATOM   8    N N    . PRO A 1 9   ? -8.21121  -6.82055  -0.24163  1.000 27.42651 ? 189  PRO A N    1 
ATOM   9    C CA   . PRO A 1 9   ? -6.93692  -6.76765  -0.97276  1.000 32.68786 ? 189  PRO A CA   1 
ATOM   10   C C    . PRO A 1 9   ? -7.13615  -6.40097  -2.43912  1.000 26.06480 ? 189  PRO A C    1 
ATOM   11   O O    . PRO A 1 9   ? -7.95576  -6.99181  -3.15304  1.000 25.55674 ? 189  PRO A O    1 
ATOM   12   C CB   . PRO A 1 9   ? -6.38743  -8.18793  -0.82059  1.000 32.45726 ? 189  PRO A CB   1 
ATOM   13   C CG   . PRO A 1 9   ? -6.90849  -8.64232  0.53949   1.000 29.52032 ? 189  PRO A CG   1 
ATOM   14   C CD   . PRO A 1 9   ? -8.25900  -7.95352  0.70718   1.000 30.51943 ? 189  PRO A CD   1 
ATOM   15   H HA   . PRO A 1 9   ? -6.33742  -6.12739  -0.55855  1.000 39.22543 ? 189  PRO A HA   1 
ATOM   16   H HB2  . PRO A 1 9   ? -6.72423  -8.75447  -1.53227  1.000 38.94871 ? 189  PRO A HB2  1 
ATOM   17   H HB3  . PRO A 1 9   ? -5.41767  -8.17459  -0.83797  1.000 38.94871 ? 189  PRO A HB3  1 
ATOM   18   H HG2  . PRO A 1 9   ? -7.00974  -9.60699  0.54738   1.000 35.42439 ? 189  PRO A HG2  1 
ATOM   19   H HG3  . PRO A 1 9   ? -6.29213  -8.36771  1.23633   1.000 35.42439 ? 189  PRO A HG3  1 
ATOM   20   H HD2  . PRO A 1 9   ? -8.98174  -8.55915  0.47964   1.000 36.62332 ? 189  PRO A HD2  1 
ATOM   21   H HD3  . PRO A 1 9   ? -8.36835  -7.63320  1.61621   1.000 36.62332 ? 189  PRO A HD3  1 
ATOM   22   N N    . ALA A 1 10  ? -6.33219  -5.44522  -2.90552  1.000 25.35884 ? 190  ALA A N    1 
ATOM   23   C CA   . ALA A 1 10  ? -6.57709  -4.86652  -4.21813  1.000 22.63584 ? 190  ALA A CA   1 
ATOM   24   C C    . ALA A 1 10  ? -6.30687  -5.85855  -5.33820  1.000 20.80109 ? 190  ALA A C    1 
ATOM   25   O O    . ALA A 1 10  ? -7.02392  -5.87548  -6.34912  1.000 20.95075 ? 190  ALA A O    1 
ATOM   26   C CB   . ALA A 1 10  ? -5.70279  -3.62666  -4.41018  1.000 26.11027 ? 190  ALA A CB   1 
ATOM   27   H H    . ALA A 1 10  ? -5.65281  -5.12265  -2.48840  1.000 30.43061 ? 190  ALA A H    1 
ATOM   28   H HA   . ALA A 1 10  ? -7.51089  -4.60785  -4.26293  1.000 27.16301 ? 190  ALA A HA   1 
ATOM   29   H HB1  . ALA A 1 10  ? -5.86935  -3.25614  -5.29102  1.000 31.33232 ? 190  ALA A HB1  1 
ATOM   30   H HB2  . ALA A 1 10  ? -5.92687  -2.97360  -3.72886  1.000 31.33232 ? 190  ALA A HB2  1 
ATOM   31   H HB3  . ALA A 1 10  ? -4.77050  -3.88209  -4.32966  1.000 31.33232 ? 190  ALA A HB3  1 
ATOM   32   N N    . LEU A 1 11  ? -5.25883  -6.67037  -5.19958  1.000 26.27005 ? 191  LEU A N    1 
ATOM   33   C CA   . LEU A 1 11  ? -4.84956  -7.52942  -6.30079  1.000 23.56323 ? 191  LEU A CA   1 
ATOM   34   C C    . LEU A 1 11  ? -5.96960  -8.46469  -6.73048  1.000 23.86518 ? 191  LEU A C    1 
ATOM   35   O O    . LEU A 1 11  ? -6.33025  -8.50736  -7.90850  1.000 23.50063 ? 191  LEU A O    1 
ATOM   36   C CB   . LEU A 1 11  ? -3.59082  -8.27909  -5.89852  1.000 24.67464 ? 191  LEU A CB   1 
ATOM   37   C CG   . LEU A 1 11  ? -2.94583  -9.19950  -6.92700  1.000 33.09180 ? 191  LEU A CG   1 
ATOM   38   C CD1  . LEU A 1 11  ? -3.73815  -10.47487 -7.14363  1.000 40.65527 ? 191  LEU A CD1  1 
ATOM   39   C CD2  . LEU A 1 11  ? -2.74698  -8.50363  -8.25253  1.000 36.76289 ? 191  LEU A CD2  1 
ATOM   40   H H    . LEU A 1 11  ? -4.77813  -6.73959  -4.48984  1.000 31.52405 ? 191  LEU A H    1 
ATOM   41   H HA   . LEU A 1 11  ? -4.63855  -6.98905  -7.07820  1.000 28.27587 ? 191  LEU A HA   1 
ATOM   42   H HB2  . LEU A 1 11  ? -2.92117  -7.62077  -5.65542  1.000 29.60957 ? 191  LEU A HB2  1 
ATOM   43   H HB3  . LEU A 1 11  ? -3.80898  -8.82968  -5.13030  1.000 29.60957 ? 191  LEU A HB3  1 
ATOM   44   H HG   . LEU A 1 11  ? -2.07837  -9.44370  -6.56814  1.000 39.71016 ? 191  LEU A HG   1 
ATOM   45   H HD11 . LEU A 1 11  ? -3.12964  -11.18462 -7.40221  1.000 48.78632 ? 191  LEU A HD11 1 
ATOM   46   H HD12 . LEU A 1 11  ? -4.18932  -10.71047 -6.31789  1.000 48.78632 ? 191  LEU A HD12 1 
ATOM   47   H HD13 . LEU A 1 11  ? -4.39032  -10.32603 -7.84607  1.000 48.78632 ? 191  LEU A HD13 1 
ATOM   48   H HD21 . LEU A 1 11  ? -2.38270  -9.13723  -8.89031  1.000 44.11546 ? 191  LEU A HD21 1 
ATOM   49   H HD22 . LEU A 1 11  ? -3.60285  -8.17274  -8.56702  1.000 44.11546 ? 191  LEU A HD22 1 
ATOM   50   H HD23 . LEU A 1 11  ? -2.13066  -7.76440  -8.13180  1.000 44.11546 ? 191  LEU A HD23 1 
ATOM   51   N N    . LYS A 1 12  ? -6.52969  -9.24194  -5.78333  1.000 25.73184 ? 192  LYS A N    1 
ATOM   52   C CA   . LYS A 1 12  ? -7.59720  -10.17348 -6.14865  1.000 21.94870 ? 192  LYS A CA   1 
ATOM   53   C C    . LYS A 1 12  ? -8.86046  -9.45888  -6.60443  1.000 19.57769 ? 192  LYS A C    1 
ATOM   54   O O    . LYS A 1 12  ? -9.51286  -9.88460  -7.55483  1.000 20.77296 ? 192  LYS A O    1 
ATOM   55   C CB   . LYS A 1 12  ? -7.91033  -11.10985 -4.97258  1.000 24.66302 ? 192  LYS A CB   1 
ATOM   56   C CG   . LYS A 1 12  ? -8.99448  -12.16958 -5.27805  1.000 29.52101 ? 192  LYS A CG   1 
ATOM   57   C CD   . LYS A 1 12  ? -9.05434  -13.24275 -4.19368  1.000 33.97568 ? 192  LYS A CD   1 
ATOM   58   H H    . LYS A 1 12  ? -6.31265  -9.24455  -4.95118  1.000 30.87821 ? 192  LYS A H    1 
ATOM   59   H HA   . LYS A 1 12  ? -7.28053  -10.70853 -6.89319  1.000 26.33843 ? 192  LYS A HA   1 
ATOM   60   H HB2  . LYS A 1 12  ? -7.09895  -11.58119 -4.72683  1.000 29.59563 ? 192  LYS A HB2  1 
ATOM   61   H HB3  . LYS A 1 12  ? -8.22293  -10.57579 -4.22561  1.000 29.59563 ? 192  LYS A HB3  1 
ATOM   62   H HG2  . LYS A 1 12  ? -9.86134  -11.73698 -5.32615  1.000 35.42521 ? 192  LYS A HG2  1 
ATOM   63   H HG3  . LYS A 1 12  ? -8.79191  -12.60145 -6.12266  1.000 35.42521 ? 192  LYS A HG3  1 
ATOM   64   N N    . LEU A 1 13  ? -9.25961  -8.39234  -5.92260  1.000 19.16157 ? 193  LEU A N    1 
ATOM   65   C CA   . LEU A 1 13  ? -10.45149 -7.67483  -6.33479  1.000 18.77896 ? 193  LEU A CA   1 
ATOM   66   C C    . LEU A 1 13  ? -10.31444 -7.16659  -7.76666  1.000 17.26509 ? 193  LEU A C    1 
ATOM   67   O O    . LEU A 1 13  ? -11.24314 -7.28907  -8.57068  1.000 17.32638 ? 193  LEU A O    1 
ATOM   68   C CB   . LEU A 1 13  ? -10.67865 -6.53592  -5.35435  1.000 20.08238 ? 193  LEU A CB   1 
ATOM   69   C CG   . LEU A 1 13  ? -11.97028 -5.78241  -5.59293  1.000 20.11245 ? 193  LEU A CG   1 
ATOM   70   C CD1  . LEU A 1 13  ? -13.20759 -6.66121  -5.58478  1.000 23.23375 ? 193  LEU A CD1  1 
ATOM   71   C CD2  . LEU A 1 13  ? -12.10145 -4.71461  -4.54819  1.000 22.28831 ? 193  LEU A CD2  1 
ATOM   72   H H    . LEU A 1 13  ? -8.86391  -8.07058  -5.23014  1.000 22.99388 ? 193  LEU A H    1 
ATOM   73   H HA   . LEU A 1 13  ? -11.22660 -8.25775  -6.31688  1.000 22.53476 ? 193  LEU A HA   1 
ATOM   74   H HB2  . LEU A 1 13  ? -10.70729 -6.89899  -4.45532  1.000 24.09885 ? 193  LEU A HB2  1 
ATOM   75   H HB3  . LEU A 1 13  ? -9.94646  -5.90469  -5.43406  1.000 24.09885 ? 193  LEU A HB3  1 
ATOM   76   H HG   . LEU A 1 13  ? -11.92781 -5.40016  -6.48342  1.000 24.13494 ? 193  LEU A HG   1 
ATOM   77   H HD11 . LEU A 1 13  ? -13.99590 -6.09646  -5.56168  1.000 27.88050 ? 193  LEU A HD11 1 
ATOM   78   H HD12 . LEU A 1 13  ? -13.21384 -7.20523  -6.38783  1.000 27.88050 ? 193  LEU A HD12 1 
ATOM   79   H HD13 . LEU A 1 13  ? -13.18543 -7.23052  -4.79973  1.000 27.88050 ? 193  LEU A HD13 1 
ATOM   80   H HD21 . LEU A 1 13  ? -12.84449 -4.13571  -4.77985  1.000 26.74598 ? 193  LEU A HD21 1 
ATOM   81   H HD22 . LEU A 1 13  ? -12.26348 -5.13260  -3.68800  1.000 26.74598 ? 193  LEU A HD22 1 
ATOM   82   H HD23 . LEU A 1 13  ? -11.27924 -4.20092  -4.51669  1.000 26.74598 ? 193  LEU A HD23 1 
ATOM   83   N N    . ALA A 1 14  ? -9.14971  -6.61477  -8.09838  1.000 17.49534 ? 194  ALA A N    1 
ATOM   84   C CA   . ALA A 1 14  ? -8.91218  -6.10764  -9.43802  1.000 16.00899 ? 194  ALA A CA   1 
ATOM   85   C C    . ALA A 1 14  ? -8.91868  -7.23405  -10.45111 1.000 16.92474 ? 194  ALA A C    1 
ATOM   86   O O    . ALA A 1 14  ? -9.66544  -7.16985  -11.44471 1.000 19.37091 ? 194  ALA A O    1 
ATOM   87   C CB   . ALA A 1 14  ? -7.55665  -5.38684  -9.47544  1.000 19.51644 ? 194  ALA A CB   1 
ATOM   88   H H    . ALA A 1 14  ? -8.48230  -6.52340  -7.56376  1.000 20.99441 ? 194  ALA A H    1 
ATOM   89   H HA   . ALA A 1 14  ? -9.61415  -5.47903  -9.66822  1.000 19.21079 ? 194  ALA A HA   1 
ATOM   90   H HB1  . ALA A 1 14  ? -7.36193  -5.12765  -10.38967 1.000 23.41972 ? 194  ALA A HB1  1 
ATOM   91   H HB2  . ALA A 1 14  ? -7.60202  -4.59936  -8.91090  1.000 23.41972 ? 194  ALA A HB2  1 
ATOM   92   H HB3  . ALA A 1 14  ? -6.86974  -5.98884  -9.14885  1.000 23.41972 ? 194  ALA A HB3  1 
ATOM   93   N N    . LEU A 1 15  ? -8.10339  -8.25980  -10.22912 1.000 17.29175 ? 195  LEU A N    1 
ATOM   94   C CA   . LEU A 1 15  ? -7.86703  -9.19811  -11.31267 1.000 17.94595 ? 195  LEU A CA   1 
ATOM   95   C C    . LEU A 1 15  ? -8.98609  -10.22392 -11.46162 1.000 20.59457 ? 195  LEU A C    1 
ATOM   96   O O    . LEU A 1 15  ? -9.23033  -10.71470 -12.56750 1.000 20.84565 ? 195  LEU A O    1 
ATOM   97   C CB   . LEU A 1 15  ? -6.54738  -9.93836  -11.08523 1.000 20.89485 ? 195  LEU A CB   1 
ATOM   98   C CG   . LEU A 1 15  ? -5.25903  -9.10204  -11.24844 1.000 22.83346 ? 195  LEU A CG   1 
ATOM   99   C CD1  . LEU A 1 15  ? -4.04989  -9.93995  -11.11938 1.000 24.83258 ? 195  LEU A CD1  1 
ATOM   100  C CD2  . LEU A 1 15  ? -5.29243  -8.36937  -12.59202 1.000 25.46770 ? 195  LEU A CD2  1 
ATOM   101  H H    . LEU A 1 15  ? -7.69364  -8.42577  -9.49145  1.000 20.75010 ? 195  LEU A H    1 
ATOM   102  H HA   . LEU A 1 15  ? -7.80970  -8.69022  -12.13708 1.000 21.53514 ? 195  LEU A HA   1 
ATOM   103  H HB2  . LEU A 1 15  ? -6.54945  -10.28728 -10.18015 1.000 25.07382 ? 195  LEU A HB2  1 
ATOM   104  H HB3  . LEU A 1 15  ? -6.49744  -10.66831 -11.72207 1.000 25.07382 ? 195  LEU A HB3  1 
ATOM   105  H HG   . LEU A 1 15  ? -5.21170  -8.44227  -10.53897 1.000 27.40016 ? 195  LEU A HG   1 
ATOM   106  H HD11 . LEU A 1 15  ? -3.26488  -9.37972  -11.22328 1.000 29.79910 ? 195  LEU A HD11 1 
ATOM   107  H HD12 . LEU A 1 15  ? -4.04589  -10.35575 -10.24303 1.000 29.79910 ? 195  LEU A HD12 1 
ATOM   108  H HD13 . LEU A 1 15  ? -4.06319  -10.62193 -11.80903 1.000 29.79910 ? 195  LEU A HD13 1 
ATOM   109  H HD21 . LEU A 1 15  ? -4.40545  -8.02942  -12.78848 1.000 30.56124 ? 195  LEU A HD21 1 
ATOM   110  H HD22 . LEU A 1 15  ? -5.56928  -8.99056  -13.28367 1.000 30.56124 ? 195  LEU A HD22 1 
ATOM   111  H HD23 . LEU A 1 15  ? -5.92323  -7.63467  -12.53549 1.000 30.56124 ? 195  LEU A HD23 1 
ATOM   112  N N    . GLU A 1 16  ? -9.64246  -10.60212 -10.37146 1.000 20.95482 ? 196  GLU A N    1 
ATOM   113  C CA   . GLU A 1 16  ? -10.61738 -11.67280 -10.42204 1.000 19.33541 ? 196  GLU A CA   1 
ATOM   114  C C    . GLU A 1 16  ? -12.04418 -11.17102 -10.48057 1.000 18.16945 ? 196  GLU A C    1 
ATOM   115  O O    . GLU A 1 16  ? -12.95646 -11.97286 -10.72102 1.000 21.02085 ? 196  GLU A O    1 
ATOM   116  C CB   . GLU A 1 16  ? -10.42479 -12.62655 -9.22300  1.000 22.31312 ? 196  GLU A CB   1 
ATOM   117  C CG   . GLU A 1 16  ? -9.01278  -13.23720 -9.17680  1.000 21.00233 ? 196  GLU A CG   1 
ATOM   118  C CD   . GLU A 1 16  ? -8.84532  -14.34839 -8.18302  1.000 25.34605 ? 196  GLU A CD   1 
ATOM   119  O OE1  . GLU A 1 16  ? -9.86728  -14.89394 -7.69638  1.000 28.38841 ? 196  GLU A OE1  1 
ATOM   120  O OE2  . GLU A 1 16  ? -7.67343  -14.65617 -7.85082  1.000 28.23597 ? 196  GLU A OE2  1 
ATOM   121  H H    . GLU A 1 16  ? -9.53811  -10.25190 -9.59296  1.000 25.14579 ? 196  GLU A H    1 
ATOM   122  H HA   . GLU A 1 16  ? -10.47392 -12.20251 -11.22186 1.000 23.20250 ? 196  GLU A HA   1 
ATOM   123  H HB2  . GLU A 1 16  ? -10.56694 -12.13322 -8.40000  1.000 26.77575 ? 196  GLU A HB2  1 
ATOM   124  H HB3  . GLU A 1 16  ? -11.06501 -13.35220 -9.28962  1.000 26.77575 ? 196  GLU A HB3  1 
ATOM   125  H HG2  . GLU A 1 16  ? -8.80206  -13.59508 -10.05339 1.000 25.20280 ? 196  GLU A HG2  1 
ATOM   126  H HG3  . GLU A 1 16  ? -8.38155  -12.53874 -8.94311  1.000 25.20280 ? 196  GLU A HG3  1 
ATOM   127  N N    . TYR A 1 17  ? -12.27781 -9.89021  -10.22892 1.000 17.15941 ? 197  TYR A N    1 
ATOM   128  C CA   . TYR A 1 17  ? -13.61690 -9.34079  -10.33045 1.000 18.41037 ? 197  TYR A CA   1 
ATOM   129  C C    . TYR A 1 17  ? -13.69285 -8.13380  -11.24282 1.000 17.35171 ? 197  TYR A C    1 
ATOM   130  O O    . TYR A 1 17  ? -14.42258 -8.15308  -12.23028 1.000 19.14267 ? 197  TYR A O    1 
ATOM   131  C CB   . TYR A 1 17  ? -14.16499 -9.03748  -8.93254  1.000 18.88120 ? 197  TYR A CB   1 
ATOM   132  C CG   . TYR A 1 17  ? -15.59261 -8.53322  -8.96731  1.000 17.65195 ? 197  TYR A CG   1 
ATOM   133  C CD1  . TYR A 1 17  ? -16.60071 -9.32716  -9.46428  1.000 20.34568 ? 197  TYR A CD1  1 
ATOM   134  C CD2  . TYR A 1 17  ? -15.90448 -7.25843  -8.56025  1.000 16.88943 ? 197  TYR A CD2  1 
ATOM   135  C CE1  . TYR A 1 17  ? -17.91293 -8.83968  -9.52652  1.000 24.86748 ? 197  TYR A CE1  1 
ATOM   136  C CE2  . TYR A 1 17  ? -17.19062 -6.79610  -8.58865  1.000 20.09218 ? 197  TYR A CE2  1 
ATOM   137  C CZ   . TYR A 1 17  ? -18.18343 -7.57660  -9.08085  1.000 23.60365 ? 197  TYR A CZ   1 
ATOM   138  O OH   . TYR A 1 17  ? -19.47943 -7.09430  -9.12512  1.000 27.61534 ? 197  TYR A OH   1 
ATOM   139  H H    . TYR A 1 17  ? -11.67653 -9.32046  -9.99773  1.000 20.59129 ? 197  TYR A H    1 
ATOM   140  H HA   . TYR A 1 17  ? -14.19089 -10.00590 -10.74163 1.000 22.09245 ? 197  TYR A HA   1 
ATOM   141  H HB2  . TYR A 1 17  ? -14.14465 -9.84885  -8.40135  1.000 22.65744 ? 197  TYR A HB2  1 
ATOM   142  H HB3  . TYR A 1 17  ? -13.61428 -8.35532  -8.51747  1.000 22.65744 ? 197  TYR A HB3  1 
ATOM   143  H HD1  . TYR A 1 17  ? -16.41083 -10.18846 -9.75924  1.000 24.41482 ? 197  TYR A HD1  1 
ATOM   144  H HD2  . TYR A 1 17  ? -15.22608 -6.69816  -8.25897  1.000 20.26731 ? 197  TYR A HD2  1 
ATOM   145  H HE1  . TYR A 1 17  ? -18.59464 -9.37180  -9.86859  1.000 29.84098 ? 197  TYR A HE1  1 
ATOM   146  H HE2  . TYR A 1 17  ? -17.38477 -5.94438  -8.26964  1.000 24.11062 ? 197  TYR A HE2  1 
ATOM   147  H HH   . TYR A 1 17  ? -19.50176 -6.30407  -8.84115  1.000 33.13840 ? 197  TYR A HH   1 
ATOM   148  N N    . ILE A 1 18  ? -12.93847 -7.07322  -10.95630 1.000 15.97918 ? 198  ILE A N    1 
ATOM   149  C CA   . ILE A 1 18  ? -13.14540 -5.82505  -11.69215 1.000 16.07507 ? 198  ILE A CA   1 
ATOM   150  C C    . ILE A 1 18  ? -12.79828 -5.99868  -13.16157 1.000 15.89075 ? 198  ILE A C    1 
ATOM   151  O O    . ILE A 1 18  ? -13.54453 -5.56123  -14.04252 1.000 16.17425 ? 198  ILE A O    1 
ATOM   152  C CB   . ILE A 1 18  ? -12.37040 -4.65585  -11.05442 1.000 16.77942 ? 198  ILE A CB   1 
ATOM   153  C CG1  . ILE A 1 18  ? -12.90372 -4.37172  -9.65532  1.000 18.89404 ? 198  ILE A CG1  1 
ATOM   154  C CG2  . ILE A 1 18  ? -12.45870 -3.36545  -11.92447 1.000 16.23218 ? 198  ILE A CG2  1 
ATOM   155  C CD1  . ILE A 1 18  ? -11.97227 -3.48257  -8.85036  1.000 19.12521 ? 198  ILE A CD1  1 
ATOM   156  H H    . ILE A 1 18  ? -12.31951 -7.04958  -10.35970 1.000 19.17502 ? 198  ILE A H    1 
ATOM   157  H HA   . ILE A 1 18  ? -14.08873 -5.60672  -11.63416 1.000 19.29009 ? 198  ILE A HA   1 
ATOM   158  H HB   . ILE A 1 18  ? -11.43889 -4.92072  -10.99941 1.000 20.13530 ? 198  ILE A HB   1 
ATOM   159  H HG12 . ILE A 1 18  ? -13.76097 -3.92363  -9.72767  1.000 22.67284 ? 198  ILE A HG12 1 
ATOM   160  H HG13 . ILE A 1 18  ? -13.00690 -5.21035  -9.17892  1.000 22.67284 ? 198  ILE A HG13 1 
ATOM   161  H HG21 . ILE A 1 18  ? -12.12531 -2.61400  -11.40962 1.000 19.47862 ? 198  ILE A HG21 1 
ATOM   162  H HG22 . ILE A 1 18  ? -11.91990 -3.48493  -12.72217 1.000 19.47862 ? 198  ILE A HG22 1 
ATOM   163  H HG23 . ILE A 1 18  ? -13.38456 -3.21314  -12.17043 1.000 19.47862 ? 198  ILE A HG23 1 
ATOM   164  H HD11 . ILE A 1 18  ? -12.24890 -3.49502  -7.92073  1.000 22.95025 ? 198  ILE A HD11 1 
ATOM   165  H HD12 . ILE A 1 18  ? -11.06631 -3.81979  -8.93043  1.000 22.95025 ? 198  ILE A HD12 1 
ATOM   166  H HD13 . ILE A 1 18  ? -12.02050 -2.57819  -9.19775  1.000 22.95025 ? 198  ILE A HD13 1 
ATOM   167  N N    . VAL A 1 19  ? -11.64926 -6.58804  -13.44691 1.000 15.66532 ? 199  VAL A N    1 
ATOM   168  C CA   . VAL A 1 19  ? -11.22171 -6.74807  -14.83597 1.000 16.51544 ? 199  VAL A CA   1 
ATOM   169  C C    . VAL A 1 19  ? -12.21808 -7.56167  -15.65131 1.000 16.65520 ? 199  VAL A C    1 
ATOM   170  O O    . VAL A 1 19  ? -12.67115 -7.07197  -16.69907 1.000 17.09373 ? 199  VAL A O    1 
ATOM   171  C CB   . VAL A 1 19  ? -9.80038  -7.34937  -14.87476 1.000 16.74070 ? 199  VAL A CB   1 
ATOM   172  C CG1  . VAL A 1 19  ? -9.49120  -7.86656  -16.26399 1.000 18.62118 ? 199  VAL A CG1  1 
ATOM   173  C CG2  . VAL A 1 19  ? -8.75061  -6.32435  -14.43360 1.000 17.96779 ? 199  VAL A CG2  1 
ATOM   174  H H    . VAL A 1 19  ? -11.09985 -6.90304  -12.86508 1.000 18.79838 ? 199  VAL A H    1 
ATOM   175  H HA   . VAL A 1 19  ? -11.18220 -5.86231  -15.22938 1.000 19.81853 ? 199  VAL A HA   1 
ATOM   176  H HB   . VAL A 1 19  ? -9.76159  -8.09168  -14.25157 1.000 20.08885 ? 199  VAL A HB   1 
ATOM   177  H HG11 . VAL A 1 19  ? -8.53444  -8.00496  -16.34376 1.000 22.34542 ? 199  VAL A HG11 1 
ATOM   178  H HG12 . VAL A 1 19  ? -9.95922  -8.70519  -16.40016 1.000 22.34542 ? 199  VAL A HG12 1 
ATOM   179  H HG13 . VAL A 1 19  ? -9.78648  -7.21310  -16.91721 1.000 22.34542 ? 199  VAL A HG13 1 
ATOM   180  H HG21 . VAL A 1 19  ? -7.87744  -6.74680  -14.43311 1.000 21.56135 ? 199  VAL A HG21 1 
ATOM   181  H HG22 . VAL A 1 19  ? -8.75699  -5.57876  -15.05404 1.000 21.56135 ? 199  VAL A HG22 1 
ATOM   182  H HG23 . VAL A 1 19  ? -8.96826  -6.01366  -13.54086 1.000 21.56135 ? 199  VAL A HG23 1 
ATOM   183  N N    . PRO A 1 20  ? -12.58552 -8.79101  -15.26979 1.000 16.23715 ? 200  PRO A N    1 
ATOM   184  C CA   . PRO A 1 20  ? -13.54756 -9.51301  -16.09170 1.000 18.25513 ? 200  PRO A CA   1 
ATOM   185  C C    . PRO A 1 20  ? -14.89857 -8.85004  -16.15709 1.000 17.57587 ? 200  PRO A C    1 
ATOM   186  O O    . PRO A 1 20  ? -15.54010 -8.85020  -17.21404 1.000 18.89027 ? 200  PRO A O    1 
ATOM   187  C CB   . PRO A 1 20  ? -13.59286 -10.90998 -15.43169 1.000 20.15211 ? 200  PRO A CB   1 
ATOM   188  C CG   . PRO A 1 20  ? -13.09153 -10.69554 -14.02516 1.000 24.51832 ? 200  PRO A CG   1 
ATOM   189  C CD   . PRO A 1 20  ? -12.07048 -9.59468  -14.14342 1.000 17.79355 ? 200  PRO A CD   1 
ATOM   190  H HA   . PRO A 1 20  ? -13.21341 -9.61042  -16.99711 1.000 21.90615 ? 200  PRO A HA   1 
ATOM   191  H HB2  . PRO A 1 20  ? -14.50360 -11.24380 -15.42822 1.000 24.18253 ? 200  PRO A HB2  1 
ATOM   192  H HB3  . PRO A 1 20  ? -13.01691 -11.52231 -15.91566 1.000 24.18253 ? 200  PRO A HB3  1 
ATOM   193  H HG2  . PRO A 1 20  ? -13.82490 -10.42858 -13.44915 1.000 29.42199 ? 200  PRO A HG2  1 
ATOM   194  H HG3  . PRO A 1 20  ? -12.68621 -11.51060 -13.69004 1.000 29.42199 ? 200  PRO A HG3  1 
ATOM   195  H HD2  . PRO A 1 20  ? -12.03224 -9.06779  -13.32989 1.000 21.35226 ? 200  PRO A HD2  1 
ATOM   196  H HD3  . PRO A 1 20  ? -11.19322 -9.95521  -14.34672 1.000 21.35226 ? 200  PRO A HD3  1 
ATOM   197  N N    A CYS A 1 21  ? -15.34064 -8.22513  -15.05657 0.526 17.51909 ? 201  CYS A N    1 
ATOM   198  N N    B CYS A 1 21  ? -15.35003 -8.19907  -15.09699 0.474 17.48724 ? 201  CYS A N    1 
ATOM   199  C CA   A CYS A 1 21  ? -16.60673 -7.51539  -15.09025 0.526 17.54368 ? 201  CYS A CA   1 
ATOM   200  C CA   B CYS A 1 21  ? -16.64286 -7.55157  -15.15827 0.474 17.48776 ? 201  CYS A CA   1 
ATOM   201  C C    A CYS A 1 21  ? -16.56971 -6.43051  -16.14772 0.526 16.88748 ? 201  CYS A C    1 
ATOM   202  C C    B CYS A 1 21  ? -16.61544 -6.36720  -16.11413 0.474 16.95096 ? 201  CYS A C    1 
ATOM   203  O O    A CYS A 1 21  ? -17.48126 -6.31463  -16.97409 0.526 17.93592 ? 201  CYS A O    1 
ATOM   204  O O    B CYS A 1 21  ? -17.57684 -6.13607  -16.86118 0.474 17.40595 ? 201  CYS A O    1 
ATOM   205  C CB   A CYS A 1 21  ? -16.89347 -6.84237  -13.74290 0.526 18.97977 ? 201  CYS A CB   1 
ATOM   206  C CB   B CYS A 1 21  ? -16.99702 -7.12771  -13.74548 0.474 18.89679 ? 201  CYS A CB   1 
ATOM   207  S SG   A CYS A 1 21  ? -17.76896 -7.84718  -12.57676 0.526 18.95813 ? 201  CYS A SG   1 
ATOM   208  S SG   B CYS A 1 21  ? -18.68496 -6.83529  -13.47471 0.474 18.45669 ? 201  CYS A SG   1 
ATOM   209  H H    A CYS A 1 21  ? -14.93066 -8.20246  -14.30092 0.526 21.02291 ? 201  CYS A H    1 
ATOM   210  H H    B CYS A 1 21  ? -14.93545 -8.12006  -14.34767 0.474 20.98469 ? 201  CYS A H    1 
ATOM   211  H HA   A CYS A 1 21  ? -17.30445 -8.16218  -15.27932 0.526 21.05242 ? 201  CYS A HA   1 
ATOM   212  H HA   B CYS A 1 21  ? -17.32531 -8.15571  -15.49019 0.474 20.98531 ? 201  CYS A HA   1 
ATOM   213  H HB2  A CYS A 1 21  ? -16.04783 -6.59521  -13.33705 0.526 22.77572 ? 201  CYS A HB2  1 
ATOM   214  H HB2  B CYS A 1 21  ? -16.72104 -7.82959  -13.13547 0.474 22.67615 ? 201  CYS A HB2  1 
ATOM   215  H HB3  A CYS A 1 21  ? -17.42867 -6.04949  -13.90352 0.526 22.77572 ? 201  CYS A HB3  1 
ATOM   216  H HB3  B CYS A 1 21  ? -16.52248 -6.30638  -13.54268 0.474 22.67615 ? 201  CYS A HB3  1 
ATOM   217  H HG   A CYS A 1 21  ? -18.24610 -7.14028  -11.73259 0.526 22.74976 ? 201  CYS A HG   1 
ATOM   218  N N    . MET A 1 22  ? -15.52610 -5.59959  -16.11848 1.000 16.15078 ? 202  MET A N    1 
ATOM   219  C CA   . MET A 1 22  ? -15.44055 -4.47928  -17.04412 1.000 15.95827 ? 202  MET A CA   1 
ATOM   220  C C    . MET A 1 22  ? -15.34760 -4.96741  -18.48195 1.000 16.02276 ? 202  MET A C    1 
ATOM   221  O O    . MET A 1 22  ? -16.00233 -4.42457  -19.37706 1.000 16.17120 ? 202  MET A O    1 
ATOM   222  C CB   . MET A 1 22  ? -14.19548 -3.65054  -16.69988 1.000 16.30697 ? 202  MET A CB   1 
ATOM   223  C CG   . MET A 1 22  ? -14.45050 -2.79071  -15.43139 1.000 16.55940 ? 202  MET A CG   1 
ATOM   224  S SD   . MET A 1 22  ? -15.78616 -1.55716  -15.60307 1.000 17.39747 ? 202  MET A SD   1 
ATOM   225  C CE   . MET A 1 22  ? -14.95466 -0.38692  -16.63660 1.000 18.87808 ? 202  MET A CE   1 
ATOM   226  H H    . MET A 1 22  ? -14.86324 -5.66724  -15.57475 1.000 19.38093 ? 202  MET A H    1 
ATOM   227  H HA   . MET A 1 22  ? -16.23075 -3.92483  -16.94884 1.000 19.14993 ? 202  MET A HA   1 
ATOM   228  H HB2  . MET A 1 22  ? -13.44798 -4.24411  -16.52719 1.000 19.56836 ? 202  MET A HB2  1 
ATOM   229  H HB3  . MET A 1 22  ? -13.98510 -3.05845  -17.43885 1.000 19.56836 ? 202  MET A HB3  1 
ATOM   230  H HG2  . MET A 1 22  ? -14.69127 -3.38185  -14.70099 1.000 19.87128 ? 202  MET A HG2  1 
ATOM   231  H HG3  . MET A 1 22  ? -13.63590 -2.31064  -15.21492 1.000 19.87128 ? 202  MET A HG3  1 
ATOM   232  H HE1  . MET A 1 22  ? -15.54976 0.35886   -16.81144 1.000 22.65370 ? 202  MET A HE1  1 
ATOM   233  H HE2  . MET A 1 22  ? -14.15725 -0.07414  -16.18141 1.000 22.65370 ? 202  MET A HE2  1 
ATOM   234  H HE3  . MET A 1 22  ? -14.71164 -0.81873  -17.47050 1.000 22.65370 ? 202  MET A HE3  1 
ATOM   235  N N    . ASN A 1 23  ? -14.50994 -5.97638  -18.73399 1.000 15.95359 ? 203  ASN A N    1 
ATOM   236  C CA   . ASN A 1 23  ? -14.31952 -6.38014  -20.11617 1.000 17.67725 ? 203  ASN A CA   1 
ATOM   237  C C    . ASN A 1 23  ? -15.58506 -7.04221  -20.66740 1.000 19.21519 ? 203  ASN A C    1 
ATOM   238  O O    . ASN A 1 23  ? -15.91163 -6.83274  -21.84608 1.000 20.71706 ? 203  ASN A O    1 
ATOM   239  C CB   . ASN A 1 23  ? -13.09159 -7.28448  -20.22576 1.000 17.50774 ? 203  ASN A CB   1 
ATOM   240  C CG   . ASN A 1 23  ? -11.77915 -6.50964  -20.09082 1.000 20.11837 ? 203  ASN A CG   1 
ATOM   241  O OD1  . ASN A 1 23  ? -11.66242 -5.35810  -20.52803 1.000 20.38156 ? 203  ASN A OD1  1 
ATOM   242  N ND2  . ASN A 1 23  ? -10.78722 -7.15130  -19.46175 1.000 21.68095 ? 203  ASN A ND2  1 
ATOM   243  H H    . ASN A 1 23  ? -14.06358 -6.41911  -18.14717 1.000 19.14431 ? 203  ASN A H    1 
ATOM   244  H HA   . ASN A 1 23  ? -14.13969 -5.60594  -20.67220 1.000 21.21270 ? 203  ASN A HA   1 
ATOM   245  H HB2  . ASN A 1 23  ? -13.12295 -7.94859  -19.51945 1.000 21.00929 ? 203  ASN A HB2  1 
ATOM   246  H HB3  . ASN A 1 23  ? -13.09565 -7.72097  -21.09198 1.000 21.00929 ? 203  ASN A HB3  1 
ATOM   247  H HD21 . ASN A 1 23  ? -10.91161 -7.94837  -19.16376 1.000 26.01714 ? 203  ASN A HD21 1 
ATOM   248  H HD22 . ASN A 1 23  ? -10.02547 -6.76652  -19.35554 1.000 26.01714 ? 203  ASN A HD22 1 
ATOM   249  N N    . LYS A 1 24  ? -16.35275 -7.76420  -19.83340 1.000 16.50561 ? 204  LYS A N    1 
ATOM   250  C CA   . LYS A 1 24  ? -17.58299 -8.40307  -20.32294 1.000 16.69628 ? 204  LYS A CA   1 
ATOM   251  C C    . LYS A 1 24  ? -18.75349 -7.43372  -20.41048 1.000 16.24001 ? 204  LYS A C    1 
ATOM   252  O O    . LYS A 1 24  ? -19.56633 -7.52805  -21.34606 1.000 21.28911 ? 204  LYS A O    1 
ATOM   253  C CB   . LYS A 1 24  ? -17.99192 -9.54727  -19.40619 1.000 17.40792 ? 204  LYS A CB   1 
ATOM   254  C CG   . LYS A 1 24  ? -17.11125 -10.72627 -19.44468 1.000 18.51675 ? 204  LYS A CG   1 
ATOM   255  C CD   . LYS A 1 24  ? -17.69963 -11.80623 -18.55208 1.000 20.68575 ? 204  LYS A CD   1 
ATOM   256  C CE   . LYS A 1 24  ? -16.99091 -13.10916 -18.77240 1.000 23.18347 ? 204  LYS A CE   1 
ATOM   257  N NZ   . LYS A 1 24  ? -17.05812 -13.58654 -20.19471 1.000 23.16600 ? 204  LYS A NZ   1 
ATOM   258  H H    . LYS A 1 24  ? -16.18648 -7.89557  -18.99992 1.000 19.80674 ? 204  LYS A H    1 
ATOM   259  H HA   . LYS A 1 24  ? -17.38692 -8.74509  -21.20922 1.000 20.03554 ? 204  LYS A HA   1 
ATOM   260  H HB2  . LYS A 1 24  ? -17.99916 -9.22037  -18.49296 1.000 20.88951 ? 204  LYS A HB2  1 
ATOM   261  H HB3  . LYS A 1 24  ? -18.88077 -9.84078  -19.66055 1.000 20.88951 ? 204  LYS A HB3  1 
ATOM   262  H HG2  . LYS A 1 24  ? -17.04964 -11.06462 -20.35167 1.000 22.22010 ? 204  LYS A HG2  1 
ATOM   263  H HG3  . LYS A 1 24  ? -16.22875 -10.49174 -19.11743 1.000 22.22010 ? 204  LYS A HG3  1 
ATOM   264  H HD2  . LYS A 1 24  ? -17.59693 -11.55140 -17.62181 1.000 24.82290 ? 204  LYS A HD2  1 
ATOM   265  H HD3  . LYS A 1 24  ? -18.63918 -11.92560 -18.76159 1.000 24.82290 ? 204  LYS A HD3  1 
ATOM   266  H HE2  . LYS A 1 24  ? -16.05574 -13.00210 -18.53812 1.000 27.82017 ? 204  LYS A HE2  1 
ATOM   267  H HE3  . LYS A 1 24  ? -17.39798 -13.78749 -18.21109 1.000 27.82017 ? 204  LYS A HE3  1 
ATOM   268  H HZ1  . LYS A 1 24  ? -16.77147 -14.42747 -20.24742 1.000 27.79920 ? 204  LYS A HZ1  1 
ATOM   269  H HZ2  . LYS A 1 24  ? -17.89709 -13.54837 -20.48929 1.000 27.79920 ? 204  LYS A HZ2  1 
ATOM   270  H HZ3  . LYS A 1 24  ? -16.54666 -13.07407 -20.71229 1.000 27.79920 ? 204  LYS A HZ3  1 
ATOM   271  N N    . HIS A 1 25  ? -18.90204 -6.52843  -19.43038 1.000 16.31517 ? 205  HIS A N    1 
ATOM   272  C CA   . HIS A 1 25  ? -20.12233 -5.74054  -19.28184 1.000 15.81185 ? 205  HIS A CA   1 
ATOM   273  C C    . HIS A 1 25  ? -19.91327 -4.23887  -19.34285 1.000 16.05434 ? 205  HIS A C    1 
ATOM   274  O O    . HIS A 1 25  ? -20.88201 -3.51976  -19.54879 1.000 16.91368 ? 205  HIS A O    1 
ATOM   275  C CB   . HIS A 1 25  ? -20.77488 -6.04201  -17.92980 1.000 17.06345 ? 205  HIS A CB   1 
ATOM   276  C CG   . HIS A 1 25  ? -20.96354 -7.50099  -17.67314 1.000 16.95003 ? 205  HIS A CG   1 
ATOM   277  N ND1  . HIS A 1 25  ? -21.72674 -8.29056  -18.49826 1.000 19.19101 ? 205  HIS A ND1  1 
ATOM   278  C CD2  . HIS A 1 25  ? -20.44503 -8.32209  -16.73285 1.000 17.38850 ? 205  HIS A CD2  1 
ATOM   279  C CE1  . HIS A 1 25  ? -21.69373 -9.53560  -18.04958 1.000 22.02325 ? 205  HIS A CE1  1 
ATOM   280  N NE2  . HIS A 1 25  ? -20.92581 -9.57107  -16.97754 1.000 19.47860 ? 205  HIS A NE2  1 
ATOM   281  H H    . HIS A 1 25  ? -18.30261 -6.35597  -18.83832 1.000 19.57820 ? 205  HIS A H    1 
ATOM   282  H HA   . HIS A 1 25  ? -20.72666 -5.99128  -19.99796 1.000 18.97422 ? 205  HIS A HA   1 
ATOM   283  H HB2  . HIS A 1 25  ? -20.21214 -5.68631  -17.22432 1.000 20.47614 ? 205  HIS A HB2  1 
ATOM   284  H HB3  . HIS A 1 25  ? -21.64781 -5.61995  -17.90244 1.000 20.47614 ? 205  HIS A HB3  1 
ATOM   285  H HD2  . HIS A 1 25  ? -19.86702 -8.07849  -16.04621 1.000 20.86620 ? 205  HIS A HD2  1 
ATOM   286  H HE1  . HIS A 1 25  ? -22.13652 -10.26163 -18.42606 1.000 26.42789 ? 205  HIS A HE1  1 
ATOM   287  H HE2  . HIS A 1 25  ? -20.75622 -10.27161 -16.50840 1.000 23.37432 ? 205  HIS A HE2  1 
ATOM   288  N N    . GLY A 1 26  ? -18.68570 -3.76110  -19.13395 1.000 16.25695 ? 206  GLY A N    1 
ATOM   289  C CA   . GLY A 1 26  ? -18.39617 -2.35075  -19.13556 1.000 16.36108 ? 206  GLY A CA   1 
ATOM   290  C C    . GLY A 1 26  ? -18.88681 -1.60837  -17.92766 1.000 15.49350 ? 206  GLY A C    1 
ATOM   291  O O    . GLY A 1 26  ? -18.80895 -0.37629  -17.90147 1.000 14.30651 ? 206  GLY A O    1 
ATOM   292  H H    . GLY A 1 26  ? -17.99575 -4.25293  -18.98673 1.000 19.50834 ? 206  GLY A H    1 
ATOM   293  H HA2  . GLY A 1 26  ? -17.43505 -2.23050  -19.18733 1.000 19.63329 ? 206  GLY A HA2  1 
ATOM   294  H HA3  . GLY A 1 26  ? -18.80718 -1.94965  -19.91729 1.000 19.63329 ? 206  GLY A HA3  1 
ATOM   295  N N    . ILE A 1 27  ? -19.34773 -2.34249  -16.91489 1.000 15.81372 ? 207  ILE A N    1 
ATOM   296  C CA   . ILE A 1 27  ? -19.89437 -1.82418  -15.66284 1.000 14.75977 ? 207  ILE A CA   1 
ATOM   297  C C    . ILE A 1 27  ? -19.50568 -2.79952  -14.56472 1.000 17.08483 ? 207  ILE A C    1 
ATOM   298  O O    . ILE A 1 27  ? -19.61164 -4.01569  -14.74244 1.000 18.10760 ? 207  ILE A O    1 
ATOM   299  C CB   . ILE A 1 27  ? -21.43639 -1.74702  -15.73129 1.000 16.53780 ? 207  ILE A CB   1 
ATOM   300  C CG1  . ILE A 1 27  ? -21.88540 -0.84158  -16.88254 1.000 14.20574 ? 207  ILE A CG1  1 
ATOM   301  C CG2  . ILE A 1 27  ? -21.98729 -1.21727  -14.38394 1.000 18.17788 ? 207  ILE A CG2  1 
ATOM   302  C CD1  . ILE A 1 27  ? -23.38833 -0.85106  -17.14658 1.000 22.15667 ? 207  ILE A CD1  1 
ATOM   303  H H    . ILE A 1 27  ? -19.35472 -3.20231  -16.93066 1.000 18.97646 ? 207  ILE A H    1 
ATOM   304  H HA   . ILE A 1 27  ? -19.52422 -0.94514  -15.48627 1.000 17.71172 ? 207  ILE A HA   1 
ATOM   305  H HB   . ILE A 1 27  ? -21.78508 -2.63706  -15.89602 1.000 19.84535 ? 207  ILE A HB   1 
ATOM   306  H HG12 . ILE A 1 27  ? -21.63028 0.07104   -16.67534 1.000 17.04688 ? 207  ILE A HG12 1 
ATOM   307  H HG13 . ILE A 1 27  ? -21.44350 -1.13320  -17.69530 1.000 17.04688 ? 207  ILE A HG13 1 
ATOM   308  H HG21 . ILE A 1 27  ? -22.93379 -1.02900  -14.48190 1.000 21.81345 ? 207  ILE A HG21 1 
ATOM   309  H HG22 . ILE A 1 27  ? -21.85334 -1.89255  -13.70060 1.000 21.81345 ? 207  ILE A HG22 1 
ATOM   310  H HG23 . ILE A 1 27  ? -21.51167 -0.40627  -14.14527 1.000 21.81345 ? 207  ILE A HG23 1 
ATOM   311  H HD11 . ILE A 1 27  ? -23.56332 -0.40791  -17.99150 1.000 26.58800 ? 207  ILE A HD11 1 
ATOM   312  H HD12 . ILE A 1 27  ? -23.69643 -1.77002  -17.18500 1.000 26.58800 ? 207  ILE A HD12 1 
ATOM   313  H HD13 . ILE A 1 27  ? -23.83832 -0.38112  -16.42716 1.000 26.58800 ? 207  ILE A HD13 1 
ATOM   314  N N    . CYS A 1 28  ? -19.11812 -2.27842  -13.40981 1.000 15.69932 ? 208  CYS A N    1 
ATOM   315  C CA   . CYS A 1 28  ? -18.72141 -3.14518  -12.28776 1.000 14.85920 ? 208  CYS A CA   1 
ATOM   316  C C    . CYS A 1 28  ? -19.07026 -2.45166  -10.98820 1.000 12.48138 ? 208  CYS A C    1 
ATOM   317  O O    . CYS A 1 28  ? -18.64288 -1.32499  -10.75185 1.000 15.42842 ? 208  CYS A O    1 
ATOM   318  C CB   . CYS A 1 28  ? -17.20663 -3.43162  -12.30122 1.000 14.65937 ? 208  CYS A CB   1 
ATOM   319  S SG   . CYS A 1 28  ? -16.66122 -4.43126  -10.91516 1.000 17.35341 ? 208  CYS A SG   1 
ATOM   320  H H    . CYS A 1 28  ? -19.07374 -1.43573  -13.24396 1.000 18.83919 ? 208  CYS A H    1 
ATOM   321  H HA   . CYS A 1 28  ? -19.20625 -3.98269  -12.35415 1.000 17.83104 ? 208  CYS A HA   1 
ATOM   322  H HB2  . CYS A 1 28  ? -16.98470 -3.90684  -13.11719 1.000 17.59124 ? 208  CYS A HB2  1 
ATOM   323  H HB3  . CYS A 1 28  ? -16.72789 -2.58866  -12.26756 1.000 17.59124 ? 208  CYS A HB3  1 
ATOM   324  H HG   . CYS A 1 28  ? -17.19560 -5.50415  -10.97304 1.000 20.82409 ? 208  CYS A HG   1 
ATOM   325  N N    . VAL A 1 29  ? -19.81105 -3.14878  -10.13245 1.000 14.73104 ? 209  VAL A N    1 
ATOM   326  C CA   . VAL A 1 29  ? -20.20053 -2.63347  -8.82348  1.000 14.84694 ? 209  VAL A CA   1 
ATOM   327  C C    . VAL A 1 29  ? -19.50836 -3.44324  -7.73487  1.000 17.60879 ? 209  VAL A C    1 
ATOM   328  O O    . VAL A 1 29  ? -19.58919 -4.67611  -7.72293  1.000 17.76250 ? 209  VAL A O    1 
ATOM   329  C CB   . VAL A 1 29  ? -21.71623 -2.73349  -8.64058  1.000 16.36691 ? 209  VAL A CB   1 
ATOM   330  C CG1  . VAL A 1 29  ? -22.15273 -2.38426  -7.24802  1.000 21.01431 ? 209  VAL A CG1  1 
ATOM   331  C CG2  . VAL A 1 29  ? -22.42167 -1.79454  -9.64159  1.000 20.50823 ? 209  VAL A CG2  1 
ATOM   332  H H    . VAL A 1 29  ? -20.10659 -3.94059  -10.29148 1.000 17.67725 ? 209  VAL A H    1 
ATOM   333  H HA   . VAL A 1 29  ? -19.90955 -1.71086  -8.75261  1.000 17.81633 ? 209  VAL A HA   1 
ATOM   334  H HB   . VAL A 1 29  ? -21.96981 -3.65570  -8.80222  1.000 19.64029 ? 209  VAL A HB   1 
ATOM   335  H HG11 . VAL A 1 29  ? -23.10815 -2.21672  -7.24922  1.000 25.21717 ? 209  VAL A HG11 1 
ATOM   336  H HG12 . VAL A 1 29  ? -21.94770 -3.12594  -6.65746  1.000 25.21717 ? 209  VAL A HG12 1 
ATOM   337  H HG13 . VAL A 1 29  ? -21.67792 -1.58962  -6.95818  1.000 25.21717 ? 209  VAL A HG13 1 
ATOM   338  H HG21 . VAL A 1 29  ? -23.38138 -1.86922  -9.52214  1.000 24.60987 ? 209  VAL A HG21 1 
ATOM   339  H HG22 . VAL A 1 29  ? -22.13737 -0.88253  -9.47331  1.000 24.60987 ? 209  VAL A HG22 1 
ATOM   340  H HG23 . VAL A 1 29  ? -22.17935 -2.05540  -10.54389 1.000 24.60987 ? 209  VAL A HG23 1 
ATOM   341  N N    . VAL A 1 30  ? -18.86320 -2.73890  -6.81873  1.000 15.14226 ? 210  VAL A N    1 
ATOM   342  C CA   . VAL A 1 30  ? -18.23282 -3.32443  -5.62729  1.000 15.61684 ? 210  VAL A CA   1 
ATOM   343  C C    . VAL A 1 30  ? -18.96867 -2.73155  -4.42879  1.000 17.75359 ? 210  VAL A C    1 
ATOM   344  O O    . VAL A 1 30  ? -18.81041 -1.54460  -4.12062  1.000 17.74866 ? 210  VAL A O    1 
ATOM   345  C CB   . VAL A 1 30  ? -16.74180 -2.98641  -5.53762  1.000 17.98441 ? 210  VAL A CB   1 
ATOM   346  C CG1  . VAL A 1 30  ? -16.17593 -3.58172  -4.26233  1.000 20.93260 ? 210  VAL A CG1  1 
ATOM   347  C CG2  . VAL A 1 30  ? -15.96684 -3.49810  -6.76304  1.000 19.59736 ? 210  VAL A CG2  1 
ATOM   348  H H    . VAL A 1 30  ? -18.76912 -1.88505  -6.85988  1.000 18.17071 ? 210  VAL A H    1 
ATOM   349  H HA   . VAL A 1 30  ? -18.33379 -4.28904  -5.64289  1.000 18.74020 ? 210  VAL A HA   1 
ATOM   350  H HB   . VAL A 1 30  ? -16.63681 -2.02223  -5.52213  1.000 21.58129 ? 210  VAL A HB   1 
ATOM   351  H HG11 . VAL A 1 30  ? -15.20719 -3.55682  -4.30492  1.000 25.11912 ? 210  VAL A HG11 1 
ATOM   352  H HG12 . VAL A 1 30  ? -16.48725 -3.06099  -3.50548  1.000 25.11912 ? 210  VAL A HG12 1 
ATOM   353  H HG13 . VAL A 1 30  ? -16.47993 -4.49917  -4.18008  1.000 25.11912 ? 210  VAL A HG13 1 
ATOM   354  H HG21 . VAL A 1 30  ? -15.02328 -3.30878  -6.64162  1.000 23.51683 ? 210  VAL A HG21 1 
ATOM   355  H HG22 . VAL A 1 30  ? -16.10420 -4.45467  -6.84671  1.000 23.51683 ? 210  VAL A HG22 1 
ATOM   356  H HG23 . VAL A 1 30  ? -16.29554 -3.04613  -7.55587  1.000 23.51683 ? 210  VAL A HG23 1 
ATOM   357  N N    . ASP A 1 31  ? -19.74731 -3.53526  -3.74066  1.000 18.99487 ? 211  ASP A N    1 
ATOM   358  C CA   . ASP A 1 31  ? -20.46615 -3.04378  -2.56734  1.000 16.41885 ? 211  ASP A CA   1 
ATOM   359  C C    . ASP A 1 31  ? -19.61343 -3.18175  -1.32448  1.000 19.74623 ? 211  ASP A C    1 
ATOM   360  O O    . ASP A 1 31  ? -18.69215 -3.99184  -1.25927  1.000 21.08047 ? 211  ASP A O    1 
ATOM   361  C CB   . ASP A 1 31  ? -21.80561 -3.73696  -2.39469  1.000 22.11999 ? 211  ASP A CB   1 
ATOM   362  C CG   . ASP A 1 31  ? -22.88807 -3.07149  -3.21738  1.000 21.94985 ? 211  ASP A CG   1 
ATOM   363  O OD1  . ASP A 1 31  ? -22.90730 -1.81061  -3.25987  1.000 25.90795 ? 211  ASP A OD1  1 
ATOM   364  O OD2  . ASP A 1 31  ? -23.73062 -3.79920  -3.79345  1.000 30.12273 ? 211  ASP A OD2  1 
ATOM   365  H H    . ASP A 1 31  ? -19.88085 -4.36473  -3.92433  1.000 22.79385 ? 211  ASP A H    1 
ATOM   366  H HA   . ASP A 1 31  ? -20.65989 -2.10137  -2.69070  1.000 19.70262 ? 211  ASP A HA   1 
ATOM   367  H HB2  . ASP A 1 31  ? -21.72820 -4.66004  -2.68248  1.000 26.54399 ? 211  ASP A HB2  1 
ATOM   368  H HB3  . ASP A 1 31  ? -22.06695 -3.70128  -1.46124  1.000 26.54399 ? 211  ASP A HB3  1 
ATOM   369  N N    . ASP A 1 32  ? -19.94448 -2.37650  -0.31763  1.000 20.87368 ? 212  ASP A N    1 
ATOM   370  C CA   . ASP A 1 32  ? -19.24695 -2.40338  0.96677   1.000 21.14175 ? 212  ASP A CA   1 
ATOM   371  C C    . ASP A 1 32  ? -17.74231 -2.28065  0.75499   1.000 18.71388 ? 212  ASP A C    1 
ATOM   372  O O    . ASP A 1 32  ? -16.94723 -3.09596  1.22615   1.000 21.47160 ? 212  ASP A O    1 
ATOM   373  C CB   . ASP A 1 32  ? -19.62819 -3.64830  1.76967   1.000 24.07848 ? 212  ASP A CB   1 
ATOM   374  C CG   . ASP A 1 32  ? -21.12106 -3.72352  2.00889   1.000 26.60783 ? 212  ASP A CG   1 
ATOM   375  O OD1  . ASP A 1 32  ? -21.65907 -2.75548  2.56950   1.000 28.01582 ? 212  ASP A OD1  1 
ATOM   376  O OD2  . ASP A 1 32  ? -21.76152 -4.71681  1.58750   1.000 31.23217 ? 212  ASP A OD2  1 
ATOM   377  H H    . ASP A 1 32  ? -20.57899 -1.79714  -0.35415  1.000 25.04842 ? 212  ASP A H    1 
ATOM   378  H HA   . ASP A 1 32  ? -19.52007 -1.63820  1.49669   1.000 25.37010 ? 212  ASP A HA   1 
ATOM   379  H HB2  . ASP A 1 32  ? -19.35797 -4.44061  1.27966   1.000 28.89418 ? 212  ASP A HB2  1 
ATOM   380  H HB3  . ASP A 1 32  ? -19.18265 -3.62282  2.63092   1.000 28.89418 ? 212  ASP A HB3  1 
ATOM   381  N N    . PHE A 1 33  ? -17.36093 -1.23051  0.02608   1.000 19.04727 ? 213  PHE A N    1 
ATOM   382  C CA   . PHE A 1 33  ? -15.97669 -1.06713  -0.41703  1.000 17.75465 ? 213  PHE A CA   1 
ATOM   383  C C    . PHE A 1 33  ? -15.02561 -0.75674  0.73083   1.000 22.10161 ? 213  PHE A C    1 
ATOM   384  O O    . PHE A 1 33  ? -13.96469 -1.38681  0.85132   1.000 22.39849 ? 213  PHE A O    1 
ATOM   385  C CB   . PHE A 1 33  ? -15.92538 0.02967   -1.48608  1.000 17.76041 ? 213  PHE A CB   1 
ATOM   386  C CG   . PHE A 1 33  ? -14.54172 0.37107   -1.98118  1.000 19.83686 ? 213  PHE A CG   1 
ATOM   387  C CD1  . PHE A 1 33  ? -13.63898 -0.64212  -2.26814  1.000 20.68416 ? 213  PHE A CD1  1 
ATOM   388  C CD2  . PHE A 1 33  ? -14.16038 1.67641   -2.16753  1.000 19.52950 ? 213  PHE A CD2  1 
ATOM   389  C CE1  . PHE A 1 33  ? -12.38031 -0.31740  -2.75985  1.000 20.01634 ? 213  PHE A CE1  1 
ATOM   390  C CE2  . PHE A 1 33  ? -12.89715 2.01460   -2.64070  1.000 19.07169 ? 213  PHE A CE2  1 
ATOM   391  C CZ   . PHE A 1 33  ? -12.00694 0.99571   -2.92699  1.000 20.26216 ? 213  PHE A CZ   1 
ATOM   392  H H    . PHE A 1 33  ? -17.88493 -0.59690  -0.22605  1.000 22.85672 ? 213  PHE A H    1 
ATOM   393  H HA   . PHE A 1 33  ? -15.67336 -1.90372  -0.80305  1.000 21.30558 ? 213  PHE A HA   1 
ATOM   394  H HB2  . PHE A 1 33  ? -16.44444 -0.26278  -2.25156  1.000 21.31249 ? 213  PHE A HB2  1 
ATOM   395  H HB3  . PHE A 1 33  ? -16.30948 0.83918   -1.11451  1.000 21.31249 ? 213  PHE A HB3  1 
ATOM   396  H HD1  . PHE A 1 33  ? -13.87409 -1.53165  -2.13260  1.000 24.82099 ? 213  PHE A HD1  1 
ATOM   397  H HD2  . PHE A 1 33  ? -14.76508 2.35522   -1.97143  1.000 23.43541 ? 213  PHE A HD2  1 
ATOM   398  H HE1  . PHE A 1 33  ? -11.78334 -0.99616  -2.97849  1.000 24.01961 ? 213  PHE A HE1  1 
ATOM   399  H HE2  . PHE A 1 33  ? -12.65674 2.90480   -2.76172  1.000 22.88602 ? 213  PHE A HE2  1 
ATOM   400  H HZ   . PHE A 1 33  ? -11.15284 1.19916   -3.23360  1.000 24.31459 ? 213  PHE A HZ   1 
ATOM   401  N N    . LEU A 1 34  ? -15.34510 0.25816   1.55731   1.000 19.84422 ? 214  LEU A N    1 
ATOM   402  C CA   . LEU A 1 34  ? -14.41658 0.70593   2.60082   1.000 22.99733 ? 214  LEU A CA   1 
ATOM   403  C C    . LEU A 1 34  ? -14.88146 0.38582   4.01032   1.000 23.61008 ? 214  LEU A C    1 
ATOM   404  O O    . LEU A 1 34  ? -14.10496 0.55774   4.94572   1.000 26.18306 ? 214  LEU A O    1 
ATOM   405  C CB   . LEU A 1 34  ? -14.15420 2.22096   2.51760   1.000 18.95805 ? 214  LEU A CB   1 
ATOM   406  C CG   . LEU A 1 34  ? -13.52314 2.66007   1.19142   1.000 21.88435 ? 214  LEU A CG   1 
ATOM   407  C CD1  . LEU A 1 34  ? -13.34429 4.15101   1.09120   1.000 22.06492 ? 214  LEU A CD1  1 
ATOM   408  C CD2  . LEU A 1 34  ? -12.17677 1.97754   1.00135   1.000 27.03796 ? 214  LEU A CD2  1 
ATOM   409  H H    . LEU A 1 34  ? -16.08584 0.69419   1.52932   1.000 23.81306 ? 214  LEU A H    1 
ATOM   410  H HA   . LEU A 1 34  ? -13.57358 0.25335   2.44136   1.000 27.59679 ? 214  LEU A HA   1 
ATOM   411  H HB2  . LEU A 1 34  ? -14.99773 2.68971   2.61572   1.000 22.74967 ? 214  LEU A HB2  1 
ATOM   412  H HB3  . LEU A 1 34  ? -13.54953 2.47281   3.23303   1.000 22.74967 ? 214  LEU A HB3  1 
ATOM   413  H HG   . LEU A 1 34  ? -14.13272 2.39807   0.48384   1.000 26.26122 ? 214  LEU A HG   1 
ATOM   414  H HD11 . LEU A 1 34  ? -12.95900 4.36549   0.22722   1.000 26.47790 ? 214  LEU A HD11 1 
ATOM   415  H HD12 . LEU A 1 34  ? -14.20951 4.57975   1.18316   1.000 26.47790 ? 214  LEU A HD12 1 
ATOM   416  H HD13 . LEU A 1 34  ? -12.75175 4.44635   1.80012   1.000 26.47790 ? 214  LEU A HD13 1 
ATOM   417  H HD21 . LEU A 1 34  ? -11.69793 2.41845   0.28217   1.000 32.44555 ? 214  LEU A HD21 1 
ATOM   418  H HD22 . LEU A 1 34  ? -11.66988 2.04394   1.82569   1.000 32.44555 ? 214  LEU A HD22 1 
ATOM   419  H HD23 . LEU A 1 34  ? -12.32410 1.04522   0.77781   1.000 32.44555 ? 214  LEU A HD23 1 
ATOM   420  N N    . GLY A 1 35  ? -16.11710 -0.05092  4.17496   1.000 22.57753 ? 215  GLY A N    1 
ATOM   421  C CA   . GLY A 1 35  ? -16.68195 -0.28397  5.47387   1.000 22.18159 ? 215  GLY A CA   1 
ATOM   422  C C    . GLY A 1 35  ? -17.38268 0.92053   6.06438   1.000 23.53776 ? 215  GLY A C    1 
ATOM   423  O O    . GLY A 1 35  ? -17.24330 2.06266   5.62022   1.000 23.20765 ? 215  GLY A O    1 
ATOM   424  H H    . GLY A 1 35  ? -16.65711 -0.22216  3.52792   1.000 27.09304 ? 215  GLY A H    1 
ATOM   425  H HA2  . GLY A 1 35  ? -17.32789 -1.00492  5.41153   1.000 26.61791 ? 215  GLY A HA2  1 
ATOM   426  H HA3  . GLY A 1 35  ? -15.97380 -0.54619  6.08269   1.000 26.61791 ? 215  GLY A HA3  1 
ATOM   427  N N    . LYS A 1 36  ? -18.16272 0.62911   7.09753   1.000 26.33861 ? 216  LYS A N    1 
ATOM   428  C CA   . LYS A 1 36  ? -19.05702 1.62279   7.68304   1.000 25.95302 ? 216  LYS A CA   1 
ATOM   429  C C    . LYS A 1 36  ? -18.29862 2.80333   8.29373   1.000 23.82043 ? 216  LYS A C    1 
ATOM   430  O O    . LYS A 1 36  ? -18.67098 3.96221   8.09489   1.000 25.90596 ? 216  LYS A O    1 
ATOM   431  C CB   . LYS A 1 36  ? -19.94756 0.94036   8.73131   1.000 30.94678 ? 216  LYS A CB   1 
ATOM   432  C CG   . LYS A 1 36  ? -21.16865 1.75044   9.20839   1.000 36.98937 ? 216  LYS A CG   1 
ATOM   433  C CD   . LYS A 1 36  ? -22.06188 0.91360   10.15870  1.000 33.36213 ? 216  LYS A CD   1 
ATOM   434  H H    . LYS A 1 36  ? -18.19517 -0.13958  7.48180   1.000 31.60634 ? 216  LYS A H    1 
ATOM   435  H HA   . LYS A 1 36  ? -19.61772 1.98728   6.98043   1.000 31.14363 ? 216  LYS A HA   1 
ATOM   436  H HB2  . LYS A 1 36  ? -20.28272 0.11282   8.35215   1.000 37.13613 ? 216  LYS A HB2  1 
ATOM   437  H HB3  . LYS A 1 36  ? -19.40544 0.75143   9.51317   1.000 37.13613 ? 216  LYS A HB3  1 
ATOM   438  H HG2  . LYS A 1 36  ? -20.86585 2.53763   9.68750   1.000 44.38724 ? 216  LYS A HG2  1 
ATOM   439  H HG3  . LYS A 1 36  ? -21.70068 2.01329   8.44109   1.000 44.38724 ? 216  LYS A HG3  1 
ATOM   440  N N    A GLU A 1 37  ? -17.24938 2.53001   9.06571   0.490 25.20524 ? 217  GLU A N    1 
ATOM   441  N N    B GLU A 1 37  ? -17.24912 2.52979   9.06523   0.510 25.19690 ? 217  GLU A N    1 
ATOM   442  C CA   A GLU A 1 37  ? -16.55655 3.62061   9.74385   0.490 24.17680 ? 217  GLU A CA   1 
ATOM   443  C CA   B GLU A 1 37  ? -16.55597 3.61970   9.74400   0.510 24.17039 ? 217  GLU A CA   1 
ATOM   444  C C    A GLU A 1 37  ? -15.97645 4.60979   8.73658   0.490 26.32802 ? 217  GLU A C    1 
ATOM   445  C C    B GLU A 1 37  ? -15.97583 4.60942   8.73718   0.510 26.32928 ? 217  GLU A C    1 
ATOM   446  O O    A GLU A 1 37  ? -16.21201 5.82579   8.82217   0.490 26.57373 ? 217  GLU A O    1 
ATOM   447  O O    B GLU A 1 37  ? -16.21110 5.82549   8.82367   0.510 26.56402 ? 217  GLU A O    1 
ATOM   448  C CB   A GLU A 1 37  ? -15.45784 3.06569   10.64357  0.490 28.35830 ? 217  GLU A CB   1 
ATOM   449  C CB   B GLU A 1 37  ? -15.45762 3.06343   10.64323  0.510 28.35767 ? 217  GLU A CB   1 
ATOM   450  C CG   A GLU A 1 37  ? -14.66323 4.15225   11.33416  0.490 34.41245 ? 217  GLU A CG   1 
ATOM   451  C CG   B GLU A 1 37  ? -14.66421 4.14897   11.33631  0.510 34.42033 ? 217  GLU A CG   1 
ATOM   452  H H    A GLU A 1 37  ? -16.92808 1.74531   9.20923   0.490 30.24628 ? 217  GLU A H    1 
ATOM   453  H H    B GLU A 1 37  ? -16.92771 1.74501   9.20812   0.510 30.23628 ? 217  GLU A H    1 
ATOM   454  H HA   A GLU A 1 37  ? -17.19232 4.09384   10.30309  0.490 29.01216 ? 217  GLU A HA   1 
ATOM   455  H HA   B GLU A 1 37  ? -17.19127 4.09307   10.30366  0.510 29.00447 ? 217  GLU A HA   1 
ATOM   456  H HB2  A GLU A 1 37  ? -15.86110 2.50783   11.32700  0.490 34.02996 ? 217  GLU A HB2  1 
ATOM   457  H HB2  B GLU A 1 37  ? -15.86102 2.50400   11.32529  0.510 34.02920 ? 217  GLU A HB2  1 
ATOM   458  H HB3  A GLU A 1 37  ? -14.84461 2.54057   10.10590  0.490 34.02996 ? 217  GLU A HB3  1 
ATOM   459  H HB3  B GLU A 1 37  ? -14.84379 2.53969   10.10489  0.510 34.02920 ? 217  GLU A HB3  1 
ATOM   460  N N    . THR A 1 38  ? -15.22115 4.10470   7.76559   1.000 23.72142 ? 218  THR A N    1 
ATOM   461  C CA   . THR A 1 38  ? -14.63320 4.99573   6.77895   1.000 22.41671 ? 218  THR A CA   1 
ATOM   462  C C    . THR A 1 38  ? -15.69940 5.67551   5.94099   1.000 23.70966 ? 218  THR A C    1 
ATOM   463  O O    . THR A 1 38  ? -15.59168 6.87665   5.65123   1.000 22.17702 ? 218  THR A O    1 
ATOM   464  C CB   . THR A 1 38  ? -13.67780 4.20709   5.90057   1.000 23.49946 ? 218  THR A CB   1 
ATOM   465  O OG1  . THR A 1 38  ? -12.61142 3.69065   6.71564   1.000 28.02700 ? 218  THR A OG1  1 
ATOM   466  C CG2  . THR A 1 38  ? -13.10581 5.07260   4.78924   1.000 24.77492 ? 218  THR A CG2  1 
ATOM   467  H H    . THR A 1 38  ? -15.04164 3.27001   7.66231   1.000 28.46570 ? 218  THR A H    1 
ATOM   468  H HA   . THR A 1 38  ? -14.13216 5.69151   7.23256   1.000 26.90005 ? 218  THR A HA   1 
ATOM   469  H HB   . THR A 1 38  ? -14.15410 3.47465   5.47918   1.000 28.19935 ? 218  THR A HB   1 
ATOM   470  H HG1  . THR A 1 38  ? -12.08280 3.23869   6.24458   1.000 33.63240 ? 218  THR A HG1  1 
ATOM   471  H HG21 . THR A 1 38  ? -12.36023 4.61899   4.36586   1.000 29.72991 ? 218  THR A HG21 1 
ATOM   472  H HG22 . THR A 1 38  ? -13.78727 5.24867   4.12177   1.000 29.72991 ? 218  THR A HG22 1 
ATOM   473  H HG23 . THR A 1 38  ? -12.79547 5.91676   5.15255   1.000 29.72991 ? 218  THR A HG23 1 
ATOM   474  N N    . GLY A 1 39  ? -16.72197 4.94002   5.52098   1.000 21.70833 ? 219  GLY A N    1 
ATOM   475  C CA   . GLY A 1 39  ? -17.79187 5.56291   4.74941   1.000 24.61699 ? 219  GLY A CA   1 
ATOM   476  C C    . GLY A 1 39  ? -18.46553 6.71528   5.47579   1.000 23.73208 ? 219  GLY A C    1 
ATOM   477  O O    . GLY A 1 39  ? -18.77876 7.74984   4.87308   1.000 23.42664 ? 219  GLY A O    1 
ATOM   478  H H    . GLY A 1 39  ? -16.82003 4.09782   5.66476   1.000 26.05000 ? 219  GLY A H    1 
ATOM   479  H HA2  . GLY A 1 39  ? -17.42666 5.90291   3.91759   1.000 29.54039 ? 219  GLY A HA2  1 
ATOM   480  H HA3  . GLY A 1 39  ? -18.46761 4.89661   4.54864   1.000 29.54039 ? 219  GLY A HA3  1 
ATOM   481  N N    . GLN A 1 40  ? -18.71857 6.56209   6.77602   0.960 22.30693 ? 220  GLN A N    1 
ATOM   482  C CA   . GLN A 1 40  ? -19.30945 7.65699   7.54261   0.960 21.77744 ? 220  GLN A CA   1 
ATOM   483  C C    . GLN A 1 40  ? -18.33813 8.81559   7.69883   0.960 22.78509 ? 220  GLN A C    1 
ATOM   484  O O    . GLN A 1 40  ? -18.77034 9.97544   7.74614   0.960 21.91040 ? 220  GLN A O    1 
ATOM   485  C CB   . GLN A 1 40  ? -19.80187 7.08194   8.87292   0.960 24.11817 ? 220  GLN A CB   1 
ATOM   486  C CG   . GLN A 1 40  ? -20.96695 6.09935   8.65460   0.960 30.14671 ? 220  GLN A CG   1 
ATOM   487  C CD   . GLN A 1 40  ? -21.98565 6.02420   9.78091   0.960 43.63581 ? 220  GLN A CD   1 
ATOM   488  O OE1  . GLN A 1 40  ? -21.78689 5.27845   10.76477  0.960 37.22171 ? 220  GLN A OE1  1 
ATOM   489  N NE2  . GLN A 1 40  ? -23.06010 6.79675   9.66807   0.960 45.12393 ? 220  GLN A NE2  1 
ATOM   490  H H    . GLN A 1 40  ? -18.56076 5.84850   7.22932   0.960 26.76832 ? 220  GLN A H    1 
ATOM   491  H HA   . GLN A 1 40  ? -20.07942 8.03666   7.09106   0.960 26.13292 ? 220  GLN A HA   1 
ATOM   492  H HB2  . GLN A 1 40  ? -19.07604 6.60657   9.30662   0.960 28.94180 ? 220  GLN A HB2  1 
ATOM   493  H HB3  . GLN A 1 40  ? -20.11155 7.80450   9.44116   0.960 28.94180 ? 220  GLN A HB3  1 
ATOM   494  H HG2  . GLN A 1 40  ? -21.44392 6.36549   7.85300   0.960 36.17605 ? 220  GLN A HG2  1 
ATOM   495  H HG3  . GLN A 1 40  ? -20.59793 5.20950   8.54104   0.960 36.17605 ? 220  GLN A HG3  1 
ATOM   496  H HE21 . GLN A 1 40  ? -23.15298 7.30659   8.98174   0.960 54.14871 ? 220  GLN A HE21 1 
ATOM   497  H HE22 . GLN A 1 40  ? -23.66294 6.78716   10.28133  0.960 54.14871 ? 220  GLN A HE22 1 
ATOM   498  N N    . GLN A 1 41  ? -17.02974 8.53505   7.76009   1.000 23.33725 ? 221  GLN A N    1 
ATOM   499  C CA   . GLN A 1 41  ? -16.06673 9.64079   7.84738   1.000 22.94697 ? 221  GLN A CA   1 
ATOM   500  C C    . GLN A 1 41  ? -16.05615 10.44431  6.54339   1.000 21.09191 ? 221  GLN A C    1 
ATOM   501  O O    . GLN A 1 41  ? -16.00141 11.68776  6.56149   1.000 22.76134 ? 221  GLN A O    1 
ATOM   502  C CB   . GLN A 1 41  ? -14.67277 9.09339   8.16250   1.000 26.20816 ? 221  GLN A CB   1 
ATOM   503  C CG   . GLN A 1 41  ? -14.51945 8.51158   9.57815   1.000 24.73739 ? 221  GLN A CG   1 
ATOM   504  C CD   . GLN A 1 41  ? -13.23166 7.70200   9.79325   1.000 35.36209 ? 221  GLN A CD   1 
ATOM   505  O OE1  . GLN A 1 41  ? -12.50005 7.37930   8.85342   1.000 38.54590 ? 221  GLN A OE1  1 
ATOM   506  N NE2  . GLN A 1 41  ? -12.98075 7.34869   11.05090  1.000 44.02913 ? 221  GLN A NE2  1 
ATOM   507  H H    . GLN A 1 41  ? -16.68722 7.74624   7.75313   1.000 28.00470 ? 221  GLN A H    1 
ATOM   508  H HA   . GLN A 1 41  ? -16.31947 10.23580  8.57056   1.000 27.53637 ? 221  GLN A HA   1 
ATOM   509  H HB2  . GLN A 1 41  ? -14.46922 8.38542   7.53142   1.000 31.44979 ? 221  GLN A HB2  1 
ATOM   510  H HB3  . GLN A 1 41  ? -14.03014 9.81420   8.07107   1.000 31.44979 ? 221  GLN A HB3  1 
ATOM   511  H HG2  . GLN A 1 41  ? -14.51595 9.24297   10.21529  1.000 29.68487 ? 221  GLN A HG2  1 
ATOM   512  H HG3  . GLN A 1 41  ? -15.26935 7.92198   9.75398   1.000 29.68487 ? 221  GLN A HG3  1 
ATOM   513  H HE21 . GLN A 1 41  ? -13.52434 7.57498   11.67772  1.000 52.83495 ? 221  GLN A HE21 1 
ATOM   514  H HE22 . GLN A 1 41  ? -12.27496 6.89399   11.23717  1.000 52.83495 ? 221  GLN A HE22 1 
ATOM   515  N N    . ILE A 1 42  ? -16.13330 9.75695   5.40839   1.000 20.41838 ? 222  ILE A N    1 
ATOM   516  C CA   . ILE A 1 42  ? -16.26502 10.43761  4.12148   1.000 18.61319 ? 222  ILE A CA   1 
ATOM   517  C C    . ILE A 1 42  ? -17.53471 11.27394  4.10672   1.000 19.08808 ? 222  ILE A C    1 
ATOM   518  O O    . ILE A 1 42  ? -17.52706 12.43294  3.68046   1.000 20.79992 ? 222  ILE A O    1 
ATOM   519  C CB   . ILE A 1 42  ? -16.22281 9.40602   2.98456   1.000 19.93923 ? 222  ILE A CB   1 
ATOM   520  C CG1  . ILE A 1 42  ? -14.82662 8.78762   2.93344   1.000 20.13753 ? 222  ILE A CG1  1 
ATOM   521  C CG2  . ILE A 1 42  ? -16.60686 10.06765  1.65315   1.000 19.91652 ? 222  ILE A CG2  1 
ATOM   522  C CD1  . ILE A 1 42  ? -14.69156 7.53635   2.11139   1.000 20.29286 ? 222  ILE A CD1  1 
ATOM   523  H H    . ILE A 1 42  ? -16.11201 8.89895   5.35372   1.000 24.50205 ? 222  ILE A H    1 
ATOM   524  H HA   . ILE A 1 42  ? -15.51969 11.04507  3.99346   1.000 22.33583 ? 222  ILE A HA   1 
ATOM   525  H HB   . ILE A 1 42  ? -16.86721 8.70008   3.14978   1.000 23.92707 ? 222  ILE A HB   1 
ATOM   526  H HG12 . ILE A 1 42  ? -14.21776 9.44355   2.55934   1.000 24.16504 ? 222  ILE A HG12 1 
ATOM   527  H HG13 . ILE A 1 42  ? -14.55966 8.56580   3.83922   1.000 24.16504 ? 222  ILE A HG13 1 
ATOM   528  H HG21 . ILE A 1 42  ? -16.32676 9.49381   0.92298   1.000 23.89982 ? 222  ILE A HG21 1 
ATOM   529  H HG22 . ILE A 1 42  ? -17.56874 10.19020  1.62728   1.000 23.89982 ? 222  ILE A HG22 1 
ATOM   530  H HG23 . ILE A 1 42  ? -16.16202 10.92715  1.58774   1.000 23.89982 ? 222  ILE A HG23 1 
ATOM   531  H HD11 . ILE A 1 42  ? -13.79000 7.19146   2.20700   1.000 24.35143 ? 222  ILE A HD11 1 
ATOM   532  H HD12 . ILE A 1 42  ? -15.33204 6.88008   2.42760   1.000 24.35143 ? 222  ILE A HD12 1 
ATOM   533  H HD13 . ILE A 1 42  ? -14.86751 7.74890   1.18146   1.000 24.35143 ? 222  ILE A HD13 1 
ATOM   534  N N    . GLY A 1 43  ? -18.64120 10.69598  4.55920   1.000 22.94020 ? 223  GLY A N    1 
ATOM   535  C CA   . GLY A 1 43  ? -19.88792 11.45466  4.63061   1.000 22.02120 ? 223  GLY A CA   1 
ATOM   536  C C    . GLY A 1 43  ? -19.76063 12.73090  5.42768   1.000 21.08111 ? 223  GLY A C    1 
ATOM   537  O O    . GLY A 1 43  ? -20.31862 13.76695  5.05633   1.000 22.47489 ? 223  GLY A O    1 
ATOM   538  H H    . GLY A 1 43  ? -18.69936 9.88082   4.82703   1.000 27.52824 ? 223  GLY A H    1 
ATOM   539  H HA2  . GLY A 1 43  ? -20.17142 11.68593  3.73225   1.000 26.42544 ? 223  GLY A HA2  1 
ATOM   540  H HA3  . GLY A 1 43  ? -20.57117 10.90542  5.04582   1.000 26.42544 ? 223  GLY A HA3  1 
ATOM   541  N N    . ASP A 1 44  ? -19.07756 12.67039  6.56565   1.000 21.13041 ? 224  ASP A N    1 
ATOM   542  C CA   . ASP A 1 44  ? -18.91054 13.87315  7.38744   1.000 22.90969 ? 224  ASP A CA   1 
ATOM   543  C C    . ASP A 1 44  ? -18.08118 14.91752  6.65348   1.000 22.45019 ? 224  ASP A C    1 
ATOM   544  O O    . ASP A 1 44  ? -18.39773 16.12042  6.68713   1.000 21.92309 ? 224  ASP A O    1 
ATOM   545  C CB   . ASP A 1 44  ? -18.22313 13.48627  8.69899   1.000 23.59660 ? 224  ASP A CB   1 
ATOM   546  C CG   . ASP A 1 44  ? -19.14027 12.75429  9.64782   1.000 32.23006 ? 224  ASP A CG   1 
ATOM   547  O OD1  . ASP A 1 44  ? -20.37394 12.70457  9.40023   1.000 29.39193 ? 224  ASP A OD1  1 
ATOM   548  O OD2  . ASP A 1 44  ? -18.61025 12.21102  10.64845  1.000 38.18109 ? 224  ASP A OD2  1 
ATOM   549  H H    . ASP A 1 44  ? -18.70645 11.96220  6.88241   1.000 25.35649 ? 224  ASP A H    1 
ATOM   550  H HA   . ASP A 1 44  ? -19.77918 14.25669  7.58555   1.000 27.49163 ? 224  ASP A HA   1 
ATOM   551  H HB2  . ASP A 1 44  ? -17.47105 12.90618  8.50210   1.000 28.31592 ? 224  ASP A HB2  1 
ATOM   552  H HB3  . ASP A 1 44  ? -17.91381 14.29143  9.14278   1.000 28.31592 ? 224  ASP A HB3  1 
ATOM   553  N N    . GLU A 1 45  ? -17.01821 14.47164  5.97312   1.000 21.55162 ? 225  GLU A N    1 
ATOM   554  C CA   . GLU A 1 45  ? -16.18753 15.39898  5.20132   1.000 19.34024 ? 225  GLU A CA   1 
ATOM   555  C C    . GLU A 1 45  ? -16.97147 16.05062  4.06040   1.000 21.62957 ? 225  GLU A C    1 
ATOM   556  O O    . GLU A 1 45  ? -16.84334 17.26273  3.80532   1.000 21.28318 ? 225  GLU A O    1 
ATOM   557  C CB   . GLU A 1 45  ? -14.96022 14.65550  4.65662   1.000 18.97835 ? 225  GLU A CB   1 
ATOM   558  C CG   . GLU A 1 45  ? -14.06887 14.19288  5.76931   1.000 22.19822 ? 225  GLU A CG   1 
ATOM   559  C CD   . GLU A 1 45  ? -12.78738 13.54766  5.29592   1.000 21.12410 ? 225  GLU A CD   1 
ATOM   560  O OE1  . GLU A 1 45  ? -12.58658 13.39765  4.07869   1.000 22.07752 ? 225  GLU A OE1  1 
ATOM   561  O OE2  . GLU A 1 45  ? -11.95941 13.20051  6.16757   1.000 27.32393 ? 225  GLU A OE2  1 
ATOM   562  H H    . GLU A 1 45  ? -16.76153 13.65139  5.94295   1.000 25.86195 ? 225  GLU A H    1 
ATOM   563  H HA   . GLU A 1 45  ? -15.88478 16.10934  5.78837   1.000 23.20829 ? 225  GLU A HA   1 
ATOM   564  H HB2  . GLU A 1 45  ? -15.25162 13.87894  4.15369   1.000 22.77401 ? 225  GLU A HB2  1 
ATOM   565  H HB3  . GLU A 1 45  ? -14.45199 15.25046  4.08336   1.000 22.77401 ? 225  GLU A HB3  1 
ATOM   566  H HG2  . GLU A 1 45  ? -13.83016 14.95750  6.31636   1.000 26.63787 ? 225  GLU A HG2  1 
ATOM   567  H HG3  . GLU A 1 45  ? -14.54878 13.54018  6.30276   1.000 26.63787 ? 225  GLU A HG3  1 
ATOM   568  N N    . VAL A 1 46  ? -17.81533 15.27517  3.38907   1.000 19.03514 ? 226  VAL A N    1 
ATOM   569  C CA   . VAL A 1 46  ? -18.62466 15.80863  2.29447   1.000 18.31204 ? 226  VAL A CA   1 
ATOM   570  C C    . VAL A 1 46  ? -19.65661 16.78439  2.84061   1.000 18.47578 ? 226  VAL A C    1 
ATOM   571  O O    . VAL A 1 46  ? -19.87433 17.85997  2.26778   1.000 19.91864 ? 226  VAL A O    1 
ATOM   572  C CB   . VAL A 1 46  ? -19.26411 14.66689  1.48449   1.000 17.65242 ? 226  VAL A CB   1 
ATOM   573  C CG1  . VAL A 1 46  ? -20.34468 15.20321  0.53205   1.000 16.83246 ? 226  VAL A CG1  1 
ATOM   574  C CG2  . VAL A 1 46  ? -18.18530 13.88440  0.73791   1.000 20.13971 ? 226  VAL A CG2  1 
ATOM   575  H H    . VAL A 1 46  ? -17.94008 14.43861  3.54461   1.000 22.84216 ? 226  VAL A H    1 
ATOM   576  H HA   . VAL A 1 46  ? -18.04804 16.29638  1.68577   1.000 21.97445 ? 226  VAL A HA   1 
ATOM   577  H HB   . VAL A 1 46  ? -19.70682 14.05391  2.09208   1.000 21.18291 ? 226  VAL A HB   1 
ATOM   578  H HG11 . VAL A 1 46  ? -20.55135 14.52191  -0.12675  1.000 20.19895 ? 226  VAL A HG11 1 
ATOM   579  H HG12 . VAL A 1 46  ? -21.13907 15.41895  1.04517   1.000 20.19895 ? 226  VAL A HG12 1 
ATOM   580  H HG13 . VAL A 1 46  ? -20.00967 15.99935  0.09065   1.000 20.19895 ? 226  VAL A HG13 1 
ATOM   581  H HG21 . VAL A 1 46  ? -18.60364 13.16090  0.24553   1.000 24.16765 ? 226  VAL A HG21 1 
ATOM   582  H HG22 . VAL A 1 46  ? -17.72939 14.48171  0.12449   1.000 24.16765 ? 226  VAL A HG22 1 
ATOM   583  H HG23 . VAL A 1 46  ? -17.55378 13.52529  1.38066   1.000 24.16765 ? 226  VAL A HG23 1 
ATOM   584  N N    . ARG A 1 47  ? -20.30250 16.43618  3.94700   0.921 19.35365 ? 227  ARG A N    1 
ATOM   585  C CA   . ARG A 1 47  ? -21.30893 17.31532  4.50988   0.921 17.72110 ? 227  ARG A CA   1 
ATOM   586  C C    . ARG A 1 47  ? -20.68755 18.61937  4.98163   0.921 20.95117 ? 227  ARG A C    1 
ATOM   587  O O    . ARG A 1 47  ? -21.33229 19.67016  4.94338   0.921 21.47851 ? 227  ARG A O    1 
ATOM   588  C CB   . ARG A 1 47  ? -22.02067 16.58659  5.65010   0.921 21.41396 ? 227  ARG A CB   1 
ATOM   589  C CG   . ARG A 1 47  ? -23.17608 15.68771  5.15495   0.921 25.45161 ? 227  ARG A CG   1 
ATOM   590  C CD   . ARG A 1 47  ? -23.93285 14.93593  6.26695   0.921 31.05494 ? 227  ARG A CD   1 
ATOM   591  N NE   . ARG A 1 47  ? -23.08826 13.98791  6.99234   0.921 32.72499 ? 227  ARG A NE   1 
ATOM   592  C CZ   . ARG A 1 47  ? -22.99791 12.70396  6.67734   0.921 33.37247 ? 227  ARG A CZ   1 
ATOM   593  N NH1  . ARG A 1 47  ? -23.63942 12.21063  5.63115   0.921 32.45250 ? 227  ARG A NH1  1 
ATOM   594  N NH2  . ARG A 1 47  ? -22.23872 11.89627  7.41999   0.921 31.05903 ? 227  ARG A NH2  1 
ATOM   595  H H    . ARG A 1 47  ? -20.17674 15.70586  4.38338   0.921 23.22438 ? 227  ARG A H    1 
ATOM   596  H HA   . ARG A 1 47  ? -21.97526 17.54013  3.84178   0.921 21.26532 ? 227  ARG A HA   1 
ATOM   597  H HB2  . ARG A 1 47  ? -21.38042 16.02471  6.11408   0.921 25.69676 ? 227  ARG A HB2  1 
ATOM   598  H HB3  . ARG A 1 47  ? -22.39090 17.24233  6.26152   0.921 25.69676 ? 227  ARG A HB3  1 
ATOM   599  H HG2  . ARG A 1 47  ? -23.82066 16.24265  4.68863   0.921 30.54194 ? 227  ARG A HG2  1 
ATOM   600  H HG3  . ARG A 1 47  ? -22.81202 15.02245  4.55014   0.921 30.54194 ? 227  ARG A HG3  1 
ATOM   601  H HD2  . ARG A 1 47  ? -24.27591 15.58004  6.90596   0.921 37.26593 ? 227  ARG A HD2  1 
ATOM   602  H HD3  . ARG A 1 47  ? -24.66577 14.43992  5.86984   0.921 37.26593 ? 227  ARG A HD3  1 
ATOM   603  H HE   . ARG A 1 47  ? -22.62667 14.27843  7.65727   0.921 39.26999 ? 227  ARG A HE   1 
ATOM   604  H HH11 . ARG A 1 47  ? -24.12509 12.72543  5.14257   0.921 38.94299 ? 227  ARG A HH11 1 
ATOM   605  H HH12 . ARG A 1 47  ? -23.57087 11.37506  5.43949   0.921 38.94299 ? 227  ARG A HH12 1 
ATOM   606  H HH21 . ARG A 1 47  ? -21.81227 12.20996  8.09774   0.921 37.27083 ? 227  ARG A HH21 1 
ATOM   607  H HH22 . ARG A 1 47  ? -22.17583 11.06200  7.22091   0.921 37.27083 ? 227  ARG A HH22 1 
ATOM   608  N N    . ALA A 1 48  ? -19.42166 18.57944  5.40107   1.000 20.44348 ? 228  ALA A N    1 
ATOM   609  C CA   . ALA A 1 48  ? -18.76714 19.81687  5.79229   1.000 21.40017 ? 228  ALA A CA   1 
ATOM   610  C C    . ALA A 1 48  ? -18.41228 20.68841  4.59273   1.000 19.01177 ? 228  ALA A C    1 
ATOM   611  O O    . ALA A 1 48  ? -18.51576 21.91573  4.68739   1.000 21.59774 ? 228  ALA A O    1 
ATOM   612  C CB   . ALA A 1 48  ? -17.54346 19.52415  6.67854   1.000 25.61894 ? 228  ALA A CB   1 
ATOM   613  H H    . ALA A 1 48  ? -18.93909 17.87045  5.46481   1.000 24.53218 ? 228  ALA A H    1 
ATOM   614  H HA   . ALA A 1 48  ? -19.38826 20.33265  6.32995   1.000 25.68020 ? 228  ALA A HA   1 
ATOM   615  H HB1  . ALA A 1 48  ? -17.13907 20.36427  6.94607   1.000 30.74273 ? 228  ALA A HB1  1 
ATOM   616  H HB2  . ALA A 1 48  ? -17.83206 19.03145  7.46267   1.000 30.74273 ? 228  ALA A HB2  1 
ATOM   617  H HB3  . ALA A 1 48  ? -16.90597 18.99653  6.17246   1.000 30.74273 ? 228  ALA A HB3  1 
ATOM   618  N N    . LEU A 1 49  ? -18.00414 20.08268  3.46810   1.000 19.13266 ? 229  LEU A N    1 
ATOM   619  C CA   . LEU A 1 49  ? -17.83883 20.87978  2.24844   1.000 18.30053 ? 229  LEU A CA   1 
ATOM   620  C C    . LEU A 1 49  ? -19.15853 21.54916  1.85746   1.000 17.65765 ? 229  LEU A C    1 
ATOM   621  O O    . LEU A 1 49  ? -19.19068 22.73032  1.47351   1.000 19.65057 ? 229  LEU A O    1 
ATOM   622  C CB   . LEU A 1 49  ? -17.37315 19.97330  1.09976   1.000 19.73294 ? 229  LEU A CB   1 
ATOM   623  C CG   . LEU A 1 49  ? -15.95921 19.41590  1.26459   1.000 18.42193 ? 229  LEU A CG   1 
ATOM   624  C CD1  . LEU A 1 49  ? -15.68382 18.31649  0.26607   1.000 17.91147 ? 229  LEU A CD1  1 
ATOM   625  C CD2  . LEU A 1 49  ? -14.88852 20.51119  1.12630   1.000 20.95279 ? 229  LEU A CD2  1 
ATOM   626  H H    . LEU A 1 49  ? -17.82393 19.24548  3.38921   1.000 22.95920 ? 229  LEU A H    1 
ATOM   627  H HA   . LEU A 1 49  ? -17.16875 21.56320  2.40601   1.000 21.96063 ? 229  LEU A HA   1 
ATOM   628  H HB2  . LEU A 1 49  ? -17.98031 19.21947  1.03653   1.000 23.67952 ? 229  LEU A HB2  1 
ATOM   629  H HB3  . LEU A 1 49  ? -17.39272 20.48507  0.27599   1.000 23.67952 ? 229  LEU A HB3  1 
ATOM   630  H HG   . LEU A 1 49  ? -15.90108 19.04848  2.16043   1.000 22.10631 ? 229  LEU A HG   1 
ATOM   631  H HD11 . LEU A 1 49  ? -14.77667 17.99648  0.39088   1.000 21.49377 ? 229  LEU A HD11 1 
ATOM   632  H HD12 . LEU A 1 49  ? -16.31290 17.59267  0.41180   1.000 21.49377 ? 229  LEU A HD12 1 
ATOM   633  H HD13 . LEU A 1 49  ? -15.78916 18.67075  -0.63076  1.000 21.49377 ? 229  LEU A HD13 1 
ATOM   634  H HD21 . LEU A 1 49  ? -14.01052 20.09979  1.15376   1.000 25.14335 ? 229  LEU A HD21 1 
ATOM   635  H HD22 . LEU A 1 49  ? -15.01284 20.96933  0.28040   1.000 25.14335 ? 229  LEU A HD22 1 
ATOM   636  H HD23 . LEU A 1 49  ? -14.98264 21.13919  1.85956   1.000 25.14335 ? 229  LEU A HD23 1 
ATOM   637  N N    . HIS A 1 50  ? -20.25614 20.80589  1.95877   1.000 20.48972 ? 230  HIS A N    1 
ATOM   638  C CA   . HIS A 1 50  ? -21.57829 21.34590  1.63964   1.000 18.57198 ? 230  HIS A CA   1 
ATOM   639  C C    . HIS A 1 50  ? -21.93572 22.50675  2.56219   1.000 19.86973 ? 230  HIS A C    1 
ATOM   640  O O    . HIS A 1 50  ? -22.29426 23.59834  2.10022   1.000 19.89273 ? 230  HIS A O    1 
ATOM   641  C CB   . HIS A 1 50  ? -22.57013 20.19164  1.77211   1.000 18.79915 ? 230  HIS A CB   1 
ATOM   642  C CG   . HIS A 1 50  ? -23.92030 20.43939  1.17596   1.000 19.43262 ? 230  HIS A CG   1 
ATOM   643  N ND1  . HIS A 1 50  ? -24.93139 19.50239  1.23313   1.000 20.95251 ? 230  HIS A ND1  1 
ATOM   644  C CD2  . HIS A 1 50  ? -24.42512 21.50797  0.49010   1.000 19.03399 ? 230  HIS A CD2  1 
ATOM   645  C CE1  . HIS A 1 50  ? -26.00219 19.98113  0.61474   1.000 24.44952 ? 230  HIS A CE1  1 
ATOM   646  N NE2  . HIS A 1 50  ? -25.71706 21.18383  0.14859   1.000 19.18363 ? 230  HIS A NE2  1 
ATOM   647  H H    . HIS A 1 50  ? -20.26605 19.98357  2.21036   1.000 24.58767 ? 230  HIS A H    1 
ATOM   648  H HA   . HIS A 1 50  ? -21.60664 21.69791  0.73621   1.000 22.28638 ? 230  HIS A HA   1 
ATOM   649  H HB2  . HIS A 1 50  ? -22.19599 19.41407  1.32904   1.000 22.55898 ? 230  HIS A HB2  1 
ATOM   650  H HB3  . HIS A 1 50  ? -22.69949 20.00581  2.71531   1.000 22.55898 ? 230  HIS A HB3  1 
ATOM   651  H HD2  . HIS A 1 50  ? -23.98099 22.30083  0.29256   1.000 22.84079 ? 230  HIS A HD2  1 
ATOM   652  H HE1  . HIS A 1 50  ? -26.81770 19.54334  0.52429   1.000 29.33943 ? 230  HIS A HE1  1 
ATOM   653  H HE2  . HIS A 1 50  ? -26.25463 21.68501  -0.29800  1.000 23.02035 ? 230  HIS A HE2  1 
ATOM   654  N N    . ASP A 1 51  ? -21.78233 22.30658  3.86730   1.000 21.28077 ? 231  ASP A N    1 
ATOM   655  C CA   . ASP A 1 51  ? -22.18915 23.28800  4.84367   1.000 24.10269 ? 231  ASP A CA   1 
ATOM   656  C C    . ASP A 1 51  ? -21.33636 24.54367  4.80635   1.000 22.68690 ? 231  ASP A C    1 
ATOM   657  O O    . ASP A 1 51  ? -21.82717 25.60731  5.21259   1.000 28.32328 ? 231  ASP A O    1 
ATOM   658  C CB   . ASP A 1 51  ? -22.14267 22.64738  6.23260   1.000 24.14948 ? 231  ASP A CB   1 
ATOM   659  C CG   . ASP A 1 51  ? -22.46371 23.60494  7.32105   1.000 43.25565 ? 231  ASP A CG   1 
ATOM   660  O OD1  . ASP A 1 51  ? -23.66847 23.89623  7.48072   1.000 69.89078 ? 231  ASP A OD1  1 
ATOM   661  O OD2  . ASP A 1 51  ? -21.53393 24.03969  8.03553   1.000 50.77772 ? 231  ASP A OD2  1 
ATOM   662  H H    . ASP A 1 51  ? -21.43914 21.59724  4.21175   1.000 25.53693 ? 231  ASP A H    1 
ATOM   663  H HA   . ASP A 1 51  ? -23.10016 23.56692  4.66153   1.000 28.92322 ? 231  ASP A HA   1 
ATOM   664  H HB2  . ASP A 1 51  ? -22.78916 21.92513  6.26885   1.000 28.97938 ? 231  ASP A HB2  1 
ATOM   665  H HB3  . ASP A 1 51  ? -21.25020 22.30204  6.39119   1.000 28.97938 ? 231  ASP A HB3  1 
ATOM   666  N N    . THR A 1 52  ? -20.09851 24.46359  4.33102   1.000 26.02341 ? 232  THR A N    1 
ATOM   667  C CA   . THR A 1 52  ? -19.21666 25.62732  4.26881   1.000 22.72901 ? 232  THR A CA   1 
ATOM   668  C C    . THR A 1 52  ? -19.23830 26.30137  2.90773   1.000 29.84685 ? 232  THR A C    1 
ATOM   669  O O    . THR A 1 52  ? -18.38738 27.15046  2.63354   1.000 30.72281 ? 232  THR A O    1 
ATOM   670  C CB   . THR A 1 52  ? -17.79947 25.25215  4.71649   1.000 25.21817 ? 232  THR A CB   1 
ATOM   671  O OG1  . THR A 1 52  ? -17.26442 24.23840  3.86055   1.000 28.26495 ? 232  THR A OG1  1 
ATOM   672  C CG2  . THR A 1 52  ? -17.86885 24.78890  6.17295   1.000 26.44358 ? 232  THR A CG2  1 
ATOM   673  H H    . THR A 1 52  ? -19.74165 23.73920  4.03520   1.000 31.22809 ? 232  THR A H    1 
ATOM   674  H HA   . THR A 1 52  ? -19.52280 26.29393  4.90348   1.000 27.27481 ? 232  THR A HA   1 
ATOM   675  H HB   . THR A 1 52  ? -17.19491 26.00867  4.66090   1.000 30.26180 ? 232  THR A HB   1 
ATOM   676  H HG1  . THR A 1 52  ? -16.49623 24.01918  4.12020   1.000 33.91794 ? 232  THR A HG1  1 
ATOM   677  H HG21 . THR A 1 52  ? -16.97885 24.58053  6.49756   1.000 31.73230 ? 232  THR A HG21 1 
ATOM   678  H HG22 . THR A 1 52  ? -18.24975 25.48891  6.72595   1.000 31.73230 ? 232  THR A HG22 1 
ATOM   679  H HG23 . THR A 1 52  ? -18.42309 23.99591  6.24282   1.000 31.73230 ? 232  THR A HG23 1 
ATOM   680  N N    . GLY A 1 53  ? -20.18426 25.95175  2.05313   1.000 21.60642 ? 233  GLY A N    1 
ATOM   681  C CA   . GLY A 1 53  ? -20.37953 26.73875  0.84832   1.000 22.88943 ? 233  GLY A CA   1 
ATOM   682  C C    . GLY A 1 53  ? -19.40762 26.43096  -0.27322  1.000 21.14595 ? 233  GLY A C    1 
ATOM   683  O O    . GLY A 1 53  ? -19.22121 27.27237  -1.17027  1.000 24.77139 ? 233  GLY A O    1 
ATOM   684  H H    . GLY A 1 53  ? -20.71359 25.28016  2.14464   1.000 25.92770 ? 233  GLY A H    1 
ATOM   685  H HA2  . GLY A 1 53  ? -21.27663 26.58047  0.51509   1.000 27.46731 ? 233  GLY A HA2  1 
ATOM   686  H HA3  . GLY A 1 53  ? -20.28676 27.67812  1.07166   1.000 27.46731 ? 233  GLY A HA3  1 
ATOM   687  N N    . LYS A 1 54  ? -18.78556 25.26722  -0.26344  1.000 17.86099 ? 234  LYS A N    1 
ATOM   688  C CA   . LYS A 1 54  ? -17.80170 24.95538  -1.29786  1.000 20.35865 ? 234  LYS A CA   1 
ATOM   689  C C    . LYS A 1 54  ? -18.43084 24.58177  -2.63504  1.000 22.85601 ? 234  LYS A C    1 
ATOM   690  O O    . LYS A 1 54  ? -17.74997 24.67542  -3.66096  1.000 20.33403 ? 234  LYS A O    1 
ATOM   691  C CB   . LYS A 1 54  ? -16.87042 23.82254  -0.86454  1.000 20.33297 ? 234  LYS A CB   1 
ATOM   692  C CG   . LYS A 1 54  ? -16.10468 24.07208  0.41820   1.000 25.67423 ? 234  LYS A CG   1 
ATOM   693  C CD   . LYS A 1 54  ? -15.26219 25.31972  0.35664   1.000 28.89527 ? 234  LYS A CD   1 
ATOM   694  C CE   . LYS A 1 54  ? -14.51057 25.47737  1.66527   1.000 37.52300 ? 234  LYS A CE   1 
ATOM   695  N NZ   . LYS A 1 54  ? -13.93044 26.83981  1.74877   1.000 55.68567 ? 234  LYS A NZ   1 
ATOM   696  H H    . LYS A 1 54  ? -18.90870 24.64662  0.31905   1.000 21.43318 ? 234  LYS A H    1 
ATOM   697  H HA   . LYS A 1 54  ? -17.26239 25.75212  -1.42135  1.000 24.43038 ? 234  LYS A HA   1 
ATOM   698  H HB2  . LYS A 1 54  ? -17.40236 23.02203  -0.73363  1.000 24.39956 ? 234  LYS A HB2  1 
ATOM   699  H HB3  . LYS A 1 54  ? -16.21841 23.67630  -1.56768  1.000 24.39956 ? 234  LYS A HB3  1 
ATOM   700  H HG2  . LYS A 1 54  ? -16.73447 24.17096  1.14928   1.000 30.80908 ? 234  LYS A HG2  1 
ATOM   701  H HG3  . LYS A 1 54  ? -15.51561 23.32018  0.58718   1.000 30.80908 ? 234  LYS A HG3  1 
ATOM   702  H HD2  . LYS A 1 54  ? -14.62122 25.24998  -0.36806  1.000 34.67433 ? 234  LYS A HD2  1 
ATOM   703  H HD3  . LYS A 1 54  ? -15.82963 26.09520  0.22419   1.000 34.67433 ? 234  LYS A HD3  1 
ATOM   704  H HE2  . LYS A 1 54  ? -15.11896 25.35069  2.41005   1.000 45.02760 ? 234  LYS A HE2  1 
ATOM   705  H HE3  . LYS A 1 54  ? -13.79122 24.82822  1.71039   1.000 45.02760 ? 234  LYS A HE3  1 
ATOM   706  H HZ1  . LYS A 1 54  ? -13.48866 26.93608  2.51537   1.000 66.82280 ? 234  LYS A HZ1  1 
ATOM   707  H HZ2  . LYS A 1 54  ? -13.36758 26.97297  1.07235   1.000 66.82280 ? 234  LYS A HZ2  1 
ATOM   708  H HZ3  . LYS A 1 54  ? -14.57789 27.44924  1.71003   1.000 66.82280 ? 234  LYS A HZ3  1 
ATOM   709  N N    . PHE A 1 55  ? -19.69797 24.16054  -2.67892  1.000 16.76193 ? 235  PHE A N    1 
ATOM   710  C CA   . PHE A 1 55  ? -20.22021 23.59959  -3.92483  1.000 14.98021 ? 235  PHE A CA   1 
ATOM   711  C C    . PHE A 1 55  ? -20.68718 24.70820  -4.87269  1.000 15.74514 ? 235  PHE A C    1 
ATOM   712  O O    . PHE A 1 55  ? -21.25273 25.71533  -4.44873  1.000 20.81024 ? 235  PHE A O    1 
ATOM   713  C CB   . PHE A 1 55  ? -21.38941 22.64589  -3.67085  1.000 17.79513 ? 235  PHE A CB   1 
ATOM   714  C CG   . PHE A 1 55  ? -21.06506 21.40989  -2.86936  1.000 15.43314 ? 235  PHE A CG   1 
ATOM   715  C CD1  . PHE A 1 55  ? -19.80376 20.87388  -2.79386  1.000 18.43279 ? 235  PHE A CD1  1 
ATOM   716  C CD2  . PHE A 1 55  ? -22.09080 20.78522  -2.20966  1.000 15.60451 ? 235  PHE A CD2  1 
ATOM   717  C CE1  . PHE A 1 55  ? -19.59144 19.67342  -2.05792  1.000 20.23179 ? 235  PHE A CE1  1 
ATOM   718  C CE2  . PHE A 1 55  ? -21.89276 19.65322  -1.45165  1.000 17.07637 ? 235  PHE A CE2  1 
ATOM   719  C CZ   . PHE A 1 55  ? -20.63874 19.09644  -1.40127  1.000 18.46976 ? 235  PHE A CZ   1 
ATOM   720  H H    . PHE A 1 55  ? -20.25434 24.18838  -2.02373  1.000 20.11432 ? 235  PHE A H    1 
ATOM   721  H HA   . PHE A 1 55  ? -19.50400 23.09903  -4.34602  1.000 17.97625 ? 235  PHE A HA   1 
ATOM   722  H HB2  . PHE A 1 55  ? -22.07703 23.12984  -3.18725  1.000 21.35416 ? 235  PHE A HB2  1 
ATOM   723  H HB3  . PHE A 1 55  ? -21.73264 22.35040  -4.52862  1.000 21.35416 ? 235  PHE A HB3  1 
ATOM   724  H HD1  . PHE A 1 55  ? -19.09159 21.29248  -3.22105  1.000 22.11935 ? 235  PHE A HD1  1 
ATOM   725  H HD2  . PHE A 1 55  ? -22.94891 21.13753  -2.27615  1.000 18.72541 ? 235  PHE A HD2  1 
ATOM   726  H HE1  . PHE A 1 55  ? -18.74648 19.28628  -2.02526  1.000 24.27814 ? 235  PHE A HE1  1 
ATOM   727  H HE2  . PHE A 1 55  ? -22.59793 19.27131  -0.98071  1.000 20.49165 ? 235  PHE A HE2  1 
ATOM   728  H HZ   . PHE A 1 55  ? -20.50165 18.31653  -0.91359  1.000 22.16372 ? 235  PHE A HZ   1 
ATOM   729  N N    . THR A 1 56  ? -20.44372 24.50489  -6.17534  1.000 16.40602 ? 236  THR A N    1 
ATOM   730  C CA   . THR A 1 56  ? -20.92269 25.39358  -7.22758  1.000 15.73034 ? 236  THR A CA   1 
ATOM   731  C C    . THR A 1 56  ? -21.59958 24.58227  -8.33009  1.000 16.95532 ? 236  THR A C    1 
ATOM   732  O O    . THR A 1 56  ? -21.45996 23.37681  -8.41501  1.000 16.54133 ? 236  THR A O    1 
ATOM   733  C CB   . THR A 1 56  ? -19.76966 26.21476  -7.83885  1.000 22.18492 ? 236  THR A CB   1 
ATOM   734  O OG1  . THR A 1 56  ? -18.78165 25.34880  -8.36689  1.000 25.48603 ? 236  THR A OG1  1 
ATOM   735  C CG2  . THR A 1 56  ? -19.13138 27.12034  -6.77321  1.000 29.54761 ? 236  THR A CG2  1 
ATOM   736  H H    . THR A 1 56  ? -19.99029 23.83892  -6.47616  1.000 19.68722 ? 236  THR A H    1 
ATOM   737  H HA   . THR A 1 56  ? -21.57773 26.00103  -6.84967  1.000 18.87641 ? 236  THR A HA   1 
ATOM   738  H HB   . THR A 1 56  ? -20.11911 26.77178  -8.55195  1.000 26.62191 ? 236  THR A HB   1 
ATOM   739  H HG1  . THR A 1 56  ? -19.11837 24.85455  -8.95675  1.000 30.58324 ? 236  THR A HG1  1 
ATOM   740  H HG21 . THR A 1 56  ? -18.43527 27.66425  -7.17381  1.000 35.45713 ? 236  THR A HG21 1 
ATOM   741  H HG22 . THR A 1 56  ? -19.80372 27.70350  -6.38749  1.000 35.45713 ? 236  THR A HG22 1 
ATOM   742  H HG23 . THR A 1 56  ? -18.74189 26.57957  -6.06839  1.000 35.45713 ? 236  THR A HG23 1 
ATOM   743  N N    . ASP A 1 57  ? -22.38218 25.25210  -9.18414  1.000 18.59131 ? 237  ASP A N    1 
ATOM   744  C CA   . ASP A 1 57  ? -23.16036 24.50728  -10.17987 1.000 18.22081 ? 237  ASP A CA   1 
ATOM   745  C C    . ASP A 1 57  ? -22.27156 23.59936  -11.03471 1.000 17.00841 ? 237  ASP A C    1 
ATOM   746  O O    . ASP A 1 57  ? -21.23853 24.02813  -11.54770 1.000 18.48729 ? 237  ASP A O    1 
ATOM   747  C CB   . ASP A 1 57  ? -23.85510 25.48793  -11.14005 1.000 16.97253 ? 237  ASP A CB   1 
ATOM   748  C CG   . ASP A 1 57  ? -25.00269 26.26452  -10.51393 1.000 28.18807 ? 237  ASP A CG   1 
ATOM   749  O OD1  . ASP A 1 57  ? -25.37306 25.99563  -9.35478  1.000 28.14085 ? 237  ASP A OD1  1 
ATOM   750  O OD2  . ASP A 1 57  ? -25.52125 27.16461  -11.21684 1.000 35.05637 ? 237  ASP A OD2  1 
ATOM   751  H H    . ASP A 1 57  ? -22.47676 26.10657  -9.20704  1.000 22.30957 ? 237  ASP A H    1 
ATOM   752  H HA   . ASP A 1 57  ? -23.80958 23.96742  -9.70241  1.000 21.86497 ? 237  ASP A HA   1 
ATOM   753  H HB2  . ASP A 1 57  ? -23.20087 26.13188  -11.45343 1.000 20.36704 ? 237  ASP A HB2  1 
ATOM   754  H HB3  . ASP A 1 57  ? -24.21340 24.98738  -11.88971 1.000 20.36704 ? 237  ASP A HB3  1 
ATOM   755  N N    . GLY A 1 58  ? -22.69556 22.34447  -11.22200 1.000 16.62977 ? 238  GLY A N    1 
ATOM   756  C CA   . GLY A 1 58  ? -21.98060 21.47026  -12.13466 1.000 15.86256 ? 238  GLY A CA   1 
ATOM   757  C C    . GLY A 1 58  ? -21.97686 22.02758  -13.54265 1.000 14.84494 ? 238  GLY A C    1 
ATOM   758  O O    . GLY A 1 58  ? -22.95612 22.61612  -13.99729 1.000 15.46820 ? 238  GLY A O    1 
ATOM   759  H H    . GLY A 1 58  ? -23.37872 21.98910  -10.83911 1.000 19.95572 ? 238  GLY A H    1 
ATOM   760  H HA2  . GLY A 1 58  ? -21.06232 21.37132  -11.83823 1.000 19.03508 ? 238  GLY A HA2  1 
ATOM   761  H HA3  . GLY A 1 58  ? -22.40388 20.59759  -12.14806 1.000 19.03508 ? 238  GLY A HA3  1 
ATOM   762  N N    . GLN A 1 59  ? -20.87539 21.83146  -14.23912 1.000 15.02350 ? 239  GLN A N    1 
ATOM   763  C CA   . GLN A 1 59  ? -20.63392 22.42508  -15.55027 1.000 15.28048 ? 239  GLN A CA   1 
ATOM   764  C C    . GLN A 1 59  ? -20.46657 21.36011  -16.62303 1.000 13.67943 ? 239  GLN A C    1 
ATOM   765  O O    . GLN A 1 59  ? -20.31730 20.17574  -16.33199 1.000 15.38758 ? 239  GLN A O    1 
ATOM   766  C CB   . GLN A 1 59  ? -19.39390 23.31783  -15.47507 1.000 16.78092 ? 239  GLN A CB   1 
ATOM   767  C CG   . GLN A 1 59  ? -19.56732 24.45463  -14.51059 1.000 18.25537 ? 239  GLN A CG   1 
ATOM   768  C CD   . GLN A 1 59  ? -20.54338 25.47480  -14.99537 1.000 19.77396 ? 239  GLN A CD   1 
ATOM   769  O OE1  . GLN A 1 59  ? -20.26762 26.17882  -15.96346 1.000 25.09607 ? 239  GLN A OE1  1 
ATOM   770  N NE2  . GLN A 1 59  ? -21.69828 25.55330  -14.36105 1.000 22.68395 ? 239  GLN A NE2  1 
ATOM   771  H H    . GLN A 1 59  ? -20.22398 21.33996  -13.96766 1.000 18.02820 ? 239  GLN A H    1 
ATOM   772  H HA   . GLN A 1 59  ? -21.40083 22.95319  -15.82203 1.000 18.33658 ? 239  GLN A HA   1 
ATOM   773  H HB2  . GLN A 1 59  ? -18.63731 22.78601  -15.18244 1.000 20.13710 ? 239  GLN A HB2  1 
ATOM   774  H HB3  . GLN A 1 59  ? -19.21761 23.69064  -16.35304 1.000 20.13710 ? 239  GLN A HB3  1 
ATOM   775  H HG2  . GLN A 1 59  ? -19.89162 24.10618  -13.66542 1.000 21.90644 ? 239  GLN A HG2  1 
ATOM   776  H HG3  . GLN A 1 59  ? -18.71219 24.89409  -14.38204 1.000 21.90644 ? 239  GLN A HG3  1 
ATOM   777  H HE21 . GLN A 1 59  ? -21.86162 25.02949  -13.69882 1.000 27.22074 ? 239  GLN A HE21 1 
ATOM   778  H HE22 . GLN A 1 59  ? -22.28739 26.12825  -14.61001 1.000 27.22074 ? 239  GLN A HE22 1 
ATOM   779  N N    . LEU A 1 60  ? -20.52942 21.80698  -17.86908 1.000 14.35189 ? 240  LEU A N    1 
ATOM   780  C CA   . LEU A 1 60  ? -20.48173 20.91612  -19.02283 1.000 13.47387 ? 240  LEU A CA   1 
ATOM   781  C C    . LEU A 1 60  ? -19.22000 21.15037  -19.85100 1.000 16.12851 ? 240  LEU A C    1 
ATOM   782  O O    . LEU A 1 60  ? -18.60512 22.20966  -19.81270 1.000 17.18577 ? 240  LEU A O    1 
ATOM   783  C CB   . LEU A 1 60  ? -21.73953 21.08706  -19.86660 1.000 17.72841 ? 240  LEU A CB   1 
ATOM   784  C CG   . LEU A 1 60  ? -23.10710 20.71898  -19.25113 1.000 17.10139 ? 240  LEU A CG   1 
ATOM   785  C CD1  . LEU A 1 60  ? -23.03478 19.34988  -18.64114 1.000 17.96018 ? 240  LEU A CD1  1 
ATOM   786  C CD2  . LEU A 1 60  ? -23.61796 21.78045  -18.28249 1.000 17.01537 ? 240  LEU A CD2  1 
ATOM   787  H H    . LEU A 1 60  ? -20.60132 22.63830  -18.07723 1.000 17.22227 ? 240  LEU A H    1 
ATOM   788  H HA   . LEU A 1 60  ? -20.44046 19.99422  -18.72400 1.000 16.16864 ? 240  LEU A HA   1 
ATOM   789  H HB2  . LEU A 1 60  ? -21.79509 22.02177  -20.11986 1.000 21.27409 ? 240  LEU A HB2  1 
ATOM   790  H HB3  . LEU A 1 60  ? -21.63669 20.53465  -20.65727 1.000 21.27409 ? 240  LEU A HB3  1 
ATOM   791  H HG   . LEU A 1 60  ? -23.77539 20.69215  -19.95367 1.000 20.52167 ? 240  LEU A HG   1 
ATOM   792  H HD11 . LEU A 1 60  ? -23.93147 19.05713  -18.41502 1.000 21.55222 ? 240  LEU A HD11 1 
ATOM   793  H HD12 . LEU A 1 60  ? -22.63921 18.73894  -19.28238 1.000 21.55222 ? 240  LEU A HD12 1 
ATOM   794  H HD13 . LEU A 1 60  ? -22.48799 19.38917  -17.84090 1.000 21.55222 ? 240  LEU A HD13 1 
ATOM   795  H HD21 . LEU A 1 60  ? -24.56973 21.65193  -18.14640 1.000 20.41845 ? 240  LEU A HD21 1 
ATOM   796  H HD22 . LEU A 1 60  ? -23.45347 22.65843  -18.66063 1.000 20.41845 ? 240  LEU A HD22 1 
ATOM   797  H HD23 . LEU A 1 60  ? -23.14804 21.69036  -17.43872 1.000 20.41845 ? 240  LEU A HD23 1 
ATOM   798  N N    . VAL A 1 61  ? -18.85489 20.15387  -20.64393 1.000 14.54867 ? 241  VAL A N    1 
ATOM   799  C CA   . VAL A 1 61  ? -17.63469 20.24361  -21.43867 1.000 17.75778 ? 241  VAL A CA   1 
ATOM   800  C C    . VAL A 1 61  ? -17.70699 21.43284  -22.39643 1.000 18.31667 ? 241  VAL A C    1 
ATOM   801  O O    . VAL A 1 61  ? -16.74928 22.21931  -22.54310 1.000 19.53865 ? 241  VAL A O    1 
ATOM   802  C CB   . VAL A 1 61  ? -17.36097 18.91001  -22.18308 1.000 15.01209 ? 241  VAL A CB   1 
ATOM   803  C CG1  . VAL A 1 61  ? -16.25834 19.08767  -23.21864 1.000 17.34049 ? 241  VAL A CG1  1 
ATOM   804  C CG2  . VAL A 1 61  ? -17.00029 17.78877  -21.20689 1.000 15.52397 ? 241  VAL A CG2  1 
ATOM   805  H H    . VAL A 1 61  ? -19.29068 19.41890  -20.74139 1.000 17.45841 ? 241  VAL A H    1 
ATOM   806  H HA   . VAL A 1 61  ? -16.88926 20.39661  -20.83716 1.000 21.30933 ? 241  VAL A HA   1 
ATOM   807  H HB   . VAL A 1 61  ? -18.17506 18.65077  -22.64237 1.000 18.01451 ? 241  VAL A HB   1 
ATOM   808  H HG11 . VAL A 1 61  ? -15.95374 18.21362  -23.50874 1.000 20.80859 ? 241  VAL A HG11 1 
ATOM   809  H HG12 . VAL A 1 61  ? -16.61168 19.58247  -23.97444 1.000 20.80859 ? 241  VAL A HG12 1 
ATOM   810  H HG13 . VAL A 1 61  ? -15.52374 19.57743  -22.81691 1.000 20.80859 ? 241  VAL A HG13 1 
ATOM   811  H HG21 . VAL A 1 61  ? -16.85898 16.96900  -21.70580 1.000 18.62876 ? 241  VAL A HG21 1 
ATOM   812  H HG22 . VAL A 1 61  ? -16.18956 18.03143  -20.73284 1.000 18.62876 ? 241  VAL A HG22 1 
ATOM   813  H HG23 . VAL A 1 61  ? -17.72898 17.67150  -20.57748 1.000 18.62876 ? 241  VAL A HG23 1 
ATOM   814  N N    . SER A 1 62  ? -18.83788 21.55726  -23.11211 1.000 18.24136 ? 242  SER A N    1 
ATOM   815  C CA   A SER A 1 62  ? -19.10922 22.61735  -24.06750 0.411 19.81014 ? 242  SER A CA   1 
ATOM   816  C CA   B SER A 1 62  ? -19.11045 22.61539  -24.06912 0.589 19.74329 ? 242  SER A CA   1 
ATOM   817  C C    . SER A 1 62  ? -20.39321 23.30727  -23.62326 1.000 19.95439 ? 242  SER A C    1 
ATOM   818  O O    . SER A 1 62  ? -21.32651 22.64070  -23.16582 1.000 22.64297 ? 242  SER A O    1 
ATOM   819  C CB   A SER A 1 62  ? -19.30931 22.01499  -25.46977 0.411 21.05840 ? 242  SER A CB   1 
ATOM   820  C CB   B SER A 1 62  ? -19.31565 22.00433  -25.47331 0.589 20.98476 ? 242  SER A CB   1 
ATOM   821  O OG   A SER A 1 62  ? -19.82227 22.97365  -26.36460 0.411 36.46796 ? 242  SER A OG   1 
ATOM   822  O OG   B SER A 1 62  ? -19.94227 22.91555  -26.34023 0.589 36.83297 ? 242  SER A OG   1 
ATOM   823  H H    A SER A 1 62  ? -19.49249 21.00299  -23.04998 0.411 21.88963 ? 242  SER A H    1 
ATOM   824  H H    B SER A 1 62  ? -19.49267 21.00333  -23.04886 0.589 21.88963 ? 242  SER A H    1 
ATOM   825  H HA   . SER A 1 62  ? -18.38576 23.26235  -24.10605 1.000 23.69195 ? 242  SER A HA   1 
ATOM   826  H HB2  A SER A 1 62  ? -18.45413 21.70009  -25.80203 0.411 25.27008 ? 242  SER A HB2  1 
ATOM   827  H HB2  B SER A 1 62  ? -18.45049 21.76533  -25.84111 0.589 25.18171 ? 242  SER A HB2  1 
ATOM   828  H HB3  A SER A 1 62  ? -19.93409 21.27553  -25.40848 0.411 25.27008 ? 242  SER A HB3  1 
ATOM   829  H HB3  B SER A 1 62  ? -19.87201 21.21378  -25.39336 0.589 25.18171 ? 242  SER A HB3  1 
ATOM   830  H HG   A SER A 1 62  ? -19.31456 23.64231  -26.39139 0.411 43.76156 ? 242  SER A HG   1 
ATOM   831  H HG   B SER A 1 62  ? -19.50166 23.62994  -26.37348 0.589 44.19956 ? 242  SER A HG   1 
ATOM   832  N N    . GLN A 1 63  ? -20.41837 24.64175  -23.72362 1.000 28.41438 ? 243  GLN A N    1 
ATOM   833  C CA   . GLN A 1 63  ? -21.51840 25.50125  -23.27711 1.000 41.12242 ? 243  GLN A CA   1 
ATOM   834  C C    . GLN A 1 63  ? -21.95354 26.32126  -24.49913 1.000 27.09035 ? 243  GLN A C    1 
ATOM   835  O O    . GLN A 1 63  ? -21.13880 26.86501  -25.23134 1.000 28.69089 ? 243  GLN A O    1 
ATOM   836  C CB   . GLN A 1 63  ? -21.01708 26.33049  -22.04008 1.000 32.63906 ? 243  GLN A CB   1 
ATOM   837  C CG   . GLN A 1 63  ? -21.95053 27.31851  -21.25958 1.000 41.08073 ? 243  GLN A CG   1 
ATOM   838  C CD   . GLN A 1 63  ? -23.18166 26.73516  -20.46273 1.000 52.34444 ? 243  GLN A CD   1 
ATOM   839  O OE1  . GLN A 1 63  ? -23.08978 25.95144  -19.45271 1.000 27.59706 ? 243  GLN A OE1  1 
ATOM   840  N NE2  . GLN A 1 63  ? -24.35186 27.16604  -20.91368 1.000 47.60964 ? 243  GLN A NE2  1 
ATOM   841  H H    . GLN A 1 63  ? -19.77312 25.09560  -24.06609 1.000 34.09725 ? 243  GLN A H    1 
ATOM   842  H HA   . GLN A 1 63  ? -22.31770 25.04268  -22.97422 1.000 49.34691 ? 243  GLN A HA   1 
ATOM   843  H HB2  . GLN A 1 63  ? -20.71097 25.68843  -21.38057 1.000 39.16687 ? 243  GLN A HB2  1 
ATOM   844  H HB3  . GLN A 1 63  ? -20.27197 26.86883  -22.34977 1.000 39.16687 ? 243  GLN A HB3  1 
ATOM   845  H HG2  . GLN A 1 63  ? -21.40252 27.78755  -20.61106 1.000 49.29688 ? 243  GLN A HG2  1 
ATOM   846  H HG3  . GLN A 1 63  ? -22.31415 27.94680  -21.90295 1.000 49.29688 ? 243  GLN A HG3  1 
ATOM   847  H HE21 . GLN A 1 63  ? -24.38240 27.71018  -21.57894 1.000 57.13157 ? 243  GLN A HE21 1 
ATOM   848  H HE22 . GLN A 1 63  ? -25.08025 26.90134  -20.54087 1.000 57.13157 ? 243  GLN A HE22 1 
ATOM   849  N N    . LYS A 1 64  ? -23.25928 26.40119  -24.72560 1.000 34.20798 ? 244  LYS A N    1 
ATOM   850  C CA   . LYS A 1 64  ? -23.90371 27.04932  -25.86466 1.000 35.18930 ? 244  LYS A CA   1 
ATOM   851  C C    . LYS A 1 64  ? -24.90211 27.95958  -25.15301 1.000 27.22806 ? 244  LYS A C    1 
ATOM   852  O O    . LYS A 1 64  ? -24.52230 28.63160  -24.19048 1.000 29.75480 ? 244  LYS A O    1 
ATOM   853  C CB   . LYS A 1 64  ? -24.58737 26.07220  -26.80450 1.000 43.56508 ? 244  LYS A CB   1 
ATOM   854  H H    . LYS A 1 64  ? -23.84228 26.06115  -24.19260 1.000 41.04958 ? 244  LYS A H    1 
ATOM   855  H HA   . LYS A 1 64  ? -23.29206 27.51000  -26.46012 1.000 42.22716 ? 244  LYS A HA   1 
ATOM   856  N N    . SER A 1 65  ? -26.11815 28.09778  -25.66185 1.000 25.36942 ? 245  SER A N    1 
ATOM   857  C CA   . SER A 1 65  ? -27.07940 28.99669  -25.00361 1.000 25.10794 ? 245  SER A CA   1 
ATOM   858  C C    . SER A 1 65  ? -27.69040 28.47069  -23.69890 1.000 23.34821 ? 245  SER A C    1 
ATOM   859  O O    . SER A 1 65  ? -28.27445 29.29265  -22.96532 1.000 24.69816 ? 245  SER A O    1 
ATOM   860  C CB   . SER A 1 65  ? -28.18654 29.34517  -25.99275 1.000 29.93724 ? 245  SER A CB   1 
ATOM   861  O OG   . SER A 1 65  ? -29.03970 28.22055  -26.19639 1.000 35.92062 ? 245  SER A OG   1 
ATOM   862  H H    . SER A 1 65  ? -26.41098 27.69865  -26.36509 1.000 30.44330 ? 245  SER A H    1 
ATOM   863  H HA   . SER A 1 65  ? -26.59594 29.79855  -24.75027 1.000 30.12953 ? 245  SER A HA   1 
ATOM   864  H HB2  . SER A 1 65  ? -28.70965 30.08108  -25.63822 1.000 35.92469 ? 245  SER A HB2  1 
ATOM   865  H HB3  . SER A 1 65  ? -27.78784 29.59933  -26.83971 1.000 35.92469 ? 245  SER A HB3  1 
ATOM   866  H HG   . SER A 1 65  ? -29.66616 28.42572  -26.71702 1.000 43.10474 ? 245  SER A HG   1 
ATOM   867  N N    . ASP A 1 66  ? -27.62791 27.17967  -23.40582 1.000 25.50829 ? 246  ASP A N    1 
ATOM   868  C CA   . ASP A 1 66  ? -28.46030 26.61781  -22.35741 1.000 26.94336 ? 246  ASP A CA   1 
ATOM   869  C C    . ASP A 1 66  ? -27.92498 26.88972  -20.95198 1.000 26.93669 ? 246  ASP A C    1 
ATOM   870  O O    . ASP A 1 66  ? -26.71312 26.87627  -20.70412 1.000 28.25165 ? 246  ASP A O    1 
ATOM   871  C CB   . ASP A 1 66  ? -28.58780 25.09553  -22.50212 1.000 26.17025 ? 246  ASP A CB   1 
ATOM   872  C CG   . ASP A 1 66  ? -28.87753 24.64138  -23.93278 1.000 35.74065 ? 246  ASP A CG   1 
ATOM   873  O OD1  . ASP A 1 66  ? -27.92721 24.42862  -24.72711 1.000 34.99981 ? 246  ASP A OD1  1 
ATOM   874  O OD2  . ASP A 1 66  ? -30.06669 24.54653  -24.28632 1.000 32.46636 ? 246  ASP A OD2  1 
ATOM   875  H H    . ASP A 1 66  ? -27.11419 26.61227  -23.79793 1.000 30.60995 ? 246  ASP A H    1 
ATOM   876  H HA   . ASP A 1 66  ? -29.32832 27.04146  -22.44666 1.000 32.33203 ? 246  ASP A HA   1 
ATOM   877  H HB2  . ASP A 1 66  ? -27.75526 24.68350  -22.22281 1.000 31.40430 ? 246  ASP A HB2  1 
ATOM   878  H HB3  . ASP A 1 66  ? -29.31555 24.78727  -21.93976 1.000 31.40430 ? 246  ASP A HB3  1 
ATOM   879  N N    . SER A 1 67  ? -28.85352 27.07711  -20.00780 1.000 23.68710 ? 247  SER A N    1 
ATOM   880  C CA   . SER A 1 67  ? -28.48754 27.00334  -18.59931 1.000 21.62644 ? 247  SER A CA   1 
ATOM   881  C C    . SER A 1 67  ? -27.98541 25.60643  -18.24809 1.000 22.34900 ? 247  SER A C    1 
ATOM   882  O O    . SER A 1 67  ? -28.63855 24.59849  -18.55678 1.000 21.32196 ? 247  SER A O    1 
ATOM   883  C CB   . SER A 1 67  ? -29.70470 27.29871  -17.75710 1.000 23.86875 ? 247  SER A CB   1 
ATOM   884  O OG   . SER A 1 67  ? -29.40795 27.05881  -16.38993 1.000 25.72567 ? 247  SER A OG   1 
ATOM   885  H H    . SER A 1 67  ? -29.68360 27.24458  -20.15791 1.000 28.42451 ? 247  SER A H    1 
ATOM   886  H HA   . SER A 1 67  ? -27.78723 27.64901  -18.41606 1.000 25.95173 ? 247  SER A HA   1 
ATOM   887  H HB2  . SER A 1 67  ? -29.95634 28.22840  -17.87222 1.000 28.64250 ? 247  SER A HB2  1 
ATOM   888  H HB3  . SER A 1 67  ? -30.43346 26.72112  -18.03315 1.000 28.64250 ? 247  SER A HB3  1 
ATOM   889  H HG   . SER A 1 67  ? -30.06248 27.27784  -15.91116 1.000 30.87081 ? 247  SER A HG   1 
ATOM   890  N N    . SER A 1 68  ? -26.84729 25.54210  -17.54141 1.000 19.08500 ? 248  SER A N    1 
ATOM   891  C CA   . SER A 1 68  ? -26.35520 24.25881  -17.07980 1.000 16.47048 ? 248  SER A CA   1 
ATOM   892  C C    . SER A 1 68  ? -27.40400 23.50159  -16.26823 1.000 16.77271 ? 248  SER A C    1 
ATOM   893  O O    . SER A 1 68  ? -27.42685 22.26310  -16.29406 1.000 16.65112 ? 248  SER A O    1 
ATOM   894  C CB   . SER A 1 68  ? -25.06725 24.37799  -16.26862 1.000 19.13611 ? 248  SER A CB   1 
ATOM   895  O OG   . SER A 1 68  ? -25.28196 25.12291  -15.07583 1.000 20.66897 ? 248  SER A OG   1 
ATOM   896  H H    . SER A 1 68  ? -26.35936 26.21664  -17.32572 1.000 22.90200 ? 248  SER A H    1 
ATOM   897  H HA   . SER A 1 68  ? -26.13841 23.74781  -17.87528 1.000 19.76458 ? 248  SER A HA   1 
ATOM   898  H HB2  . SER A 1 68  ? -24.75968 23.48860  -16.03346 1.000 22.96334 ? 248  SER A HB2  1 
ATOM   899  H HB3  . SER A 1 68  ? -24.39742 24.82946  -16.80565 1.000 22.96334 ? 248  SER A HB3  1 
ATOM   900  H HG   . SER A 1 68  ? -24.55696 25.21884  -14.66259 1.000 24.80276 ? 248  SER A HG   1 
ATOM   901  N N    . LYS A 1 69  ? -28.26649 24.21217  -15.54735 1.000 19.01172 ? 249  LYS A N    1 
ATOM   902  C CA   . LYS A 1 69  ? -29.23565 23.55308  -14.65430 1.000 20.45264 ? 249  LYS A CA   1 
ATOM   903  C C    . LYS A 1 69  ? -30.34156 22.82881  -15.38809 1.000 23.52186 ? 249  LYS A C    1 
ATOM   904  O O    . LYS A 1 69  ? -31.03928 22.00163  -14.76928 1.000 20.48173 ? 249  LYS A O    1 
ATOM   905  C CB   . LYS A 1 69  ? -29.84430 24.59094  -13.71516 1.000 23.45888 ? 249  LYS A CB   1 
ATOM   906  C CG   . LYS A 1 69  ? -28.87720 24.99236  -12.63248 1.000 22.33356 ? 249  LYS A CG   1 
ATOM   907  C CD   . LYS A 1 69  ? -29.52360 25.90879  -11.62662 1.000 29.00004 ? 249  LYS A CD   1 
ATOM   908  C CE   . LYS A 1 69  ? -28.65628 25.98096  -10.37162 1.000 39.10390 ? 249  LYS A CE   1 
ATOM   909  H H    . LYS A 1 69  ? -28.31629 25.07071  -15.55227 1.000 22.81406 ? 249  LYS A H    1 
ATOM   910  H HA   . LYS A 1 69  ? -28.76236 22.89070  -14.12690 1.000 24.54317 ? 249  LYS A HA   1 
ATOM   911  H HB2  . LYS A 1 69  ? -30.08029 25.38300  -14.22294 1.000 28.15065 ? 249  LYS A HB2  1 
ATOM   912  H HB3  . LYS A 1 69  ? -30.63528 24.21813  -13.29531 1.000 28.15065 ? 249  LYS A HB3  1 
ATOM   913  H HG2  . LYS A 1 69  ? -28.56799 24.19915  -12.16762 1.000 26.80027 ? 249  LYS A HG2  1 
ATOM   914  H HG3  . LYS A 1 69  ? -28.12505 25.45824  -13.03011 1.000 26.80027 ? 249  LYS A HG3  1 
ATOM   915  H HD2  . LYS A 1 69  ? -29.60847 26.79985  -12.00039 1.000 34.80005 ? 249  LYS A HD2  1 
ATOM   916  H HD3  . LYS A 1 69  ? -30.39800 25.56620  -11.38381 1.000 34.80005 ? 249  LYS A HD3  1 
ATOM   917  N N    . ASP A 1 70  ? -30.54224 23.09329  -16.68529 1.000 18.28435 ? 250  ASP A N    1 
ATOM   918  C CA   . ASP A 1 70  ? -31.47422 22.28727  -17.47642 1.000 19.23853 ? 250  ASP A CA   1 
ATOM   919  C C    . ASP A 1 70  ? -30.85297 20.96728  -17.91579 1.000 18.63399 ? 250  ASP A C    1 
ATOM   920  O O    . ASP A 1 70  ? -31.56960 20.13736  -18.51222 1.000 22.33960 ? 250  ASP A O    1 
ATOM   921  C CB   . ASP A 1 70  ? -31.94275 23.08099  -18.69312 1.000 20.52966 ? 250  ASP A CB   1 
ATOM   922  C CG   . ASP A 1 70  ? -32.95099 24.09921  -18.34261 1.000 23.05379 ? 250  ASP A CG   1 
ATOM   923  O OD1  . ASP A 1 70  ? -33.87435 23.80225  -17.51807 1.000 24.00056 ? 250  ASP A OD1  1 
ATOM   924  O OD2  . ASP A 1 70  ? -32.91839 25.21518  -18.92703 1.000 25.14740 ? 250  ASP A OD2  1 
ATOM   925  H H    . ASP A 1 70  ? -30.15541 23.72521  -17.12193 1.000 21.94122 ? 250  ASP A H    1 
ATOM   926  H HA   . ASP A 1 70  ? -32.26109 22.08495  -16.94651 1.000 23.08624 ? 250  ASP A HA   1 
ATOM   927  H HB2  . ASP A 1 70  ? -31.18192 23.53349  -19.08971 1.000 24.63559 ? 250  ASP A HB2  1 
ATOM   928  H HB3  . ASP A 1 70  ? -32.33907 22.47254  -19.33625 1.000 24.63559 ? 250  ASP A HB3  1 
ATOM   929  N N    . ILE A 1 71  ? -29.56619 20.80603  -17.68617 1.000 16.25535 ? 251  ILE A N    1 
ATOM   930  C CA   . ILE A 1 71  ? -28.82346 19.60649  -18.04615 1.000 17.62613 ? 251  ILE A CA   1 
ATOM   931  C C    . ILE A 1 71  ? -28.46463 18.79363  -16.81428 1.000 16.05479 ? 251  ILE A C    1 
ATOM   932  O O    . ILE A 1 71  ? -28.77708 17.60016  -16.72342 1.000 17.20972 ? 251  ILE A O    1 
ATOM   933  C CB   . ILE A 1 71  ? -27.55044 19.97594  -18.85975 1.000 17.10343 ? 251  ILE A CB   1 
ATOM   934  C CG1  . ILE A 1 71  ? -28.02951 20.63744  -20.15167 1.000 22.06954 ? 251  ILE A CG1  1 
ATOM   935  C CG2  . ILE A 1 71  ? -26.72554 18.73788  -19.13066 1.000 17.87813 ? 251  ILE A CG2  1 
ATOM   936  C CD1  . ILE A 1 71  ? -26.99934 21.45132  -20.87865 1.000 23.63845 ? 251  ILE A CD1  1 
ATOM   937  H H    . ILE A 1 71  ? -29.07571 21.40155  -17.30619 1.000 19.50642 ? 251  ILE A H    1 
ATOM   938  H HA   . ILE A 1 71  ? -29.38515 19.04986  -18.60790 1.000 21.15136 ? 251  ILE A HA   1 
ATOM   939  H HB   . ILE A 1 71  ? -26.97925 20.58638  -18.36781 1.000 20.52411 ? 251  ILE A HB   1 
ATOM   940  H HG12 . ILE A 1 71  ? -28.32906 19.94210  -20.75803 1.000 26.48345 ? 251  ILE A HG12 1 
ATOM   941  H HG13 . ILE A 1 71  ? -28.76667 21.23000  -19.93631 1.000 26.48345 ? 251  ILE A HG13 1 
ATOM   942  H HG21 . ILE A 1 71  ? -26.07933 18.93502  -19.82668 1.000 21.45376 ? 251  ILE A HG21 1 
ATOM   943  H HG22 . ILE A 1 71  ? -26.26614 18.48003  -18.31619 1.000 21.45376 ? 251  ILE A HG22 1 
ATOM   944  H HG23 . ILE A 1 71  ? -27.31434 18.02291  -19.41883 1.000 21.45376 ? 251  ILE A HG23 1 
ATOM   945  H HD11 . ILE A 1 71  ? -27.40044 21.82764  -21.67765 1.000 28.36614 ? 251  ILE A HD11 1 
ATOM   946  H HD12 . ILE A 1 71  ? -26.69100 22.16333  -20.29652 1.000 28.36614 ? 251  ILE A HD12 1 
ATOM   947  H HD13 . ILE A 1 71  ? -26.25622 20.87679  -21.12072 1.000 28.36614 ? 251  ILE A HD13 1 
ATOM   948  N N    . ARG A 1 72  ? -27.81644 19.42243  -15.84210 1.000 15.30583 ? 252  ARG A N    1 
ATOM   949  C CA   . ARG A 1 72  ? -27.42694 18.73882  -14.60653 1.000 15.19068 ? 252  ARG A CA   1 
ATOM   950  C C    . ARG A 1 72  ? -27.75076 19.64918  -13.43302 1.000 15.80313 ? 252  ARG A C    1 
ATOM   951  O O    . ARG A 1 72  ? -27.43107 20.83765  -13.44215 1.000 16.74198 ? 252  ARG A O    1 
ATOM   952  C CB   . ARG A 1 72  ? -25.94499 18.34238  -14.61031 1.000 15.86482 ? 252  ARG A CB   1 
ATOM   953  C CG   . ARG A 1 72  ? -24.93654 19.49797  -14.72914 1.000 14.42071 ? 252  ARG A CG   1 
ATOM   954  C CD   . ARG A 1 72  ? -23.50402 19.04920  -14.86697 1.000 15.93135 ? 252  ARG A CD   1 
ATOM   955  N NE   . ARG A 1 72  ? -23.03752 18.39660  -13.64934 1.000 14.80187 ? 252  ARG A NE   1 
ATOM   956  C CZ   . ARG A 1 72  ? -21.78068 18.04059  -13.43370 1.000 13.85508 ? 252  ARG A CZ   1 
ATOM   957  N NH1  . ARG A 1 72  ? -20.84733 18.25524  -14.32557 1.000 14.25936 ? 252  ARG A NH1  1 
ATOM   958  N NH2  . ARG A 1 72  ? -21.46669 17.43562  -12.28749 1.000 14.99143 ? 252  ARG A NH2  1 
ATOM   959  H H    . ARG A 1 72  ? -27.58749 20.25090  -15.87082 1.000 18.36699 ? 252  ARG A H    1 
ATOM   960  H HA   . ARG A 1 72  ? -27.93670 17.91938  -14.50875 1.000 18.22882 ? 252  ARG A HA   1 
ATOM   961  H HB2  . ARG A 1 72  ? -25.75326 17.87942  -13.77977 1.000 19.03779 ? 252  ARG A HB2  1 
ATOM   962  H HB3  . ARG A 1 72  ? -25.79185 17.75026  -15.36320 1.000 19.03779 ? 252  ARG A HB3  1 
ATOM   963  H HG2  . ARG A 1 72  ? -25.15674 20.02456  -15.51344 1.000 17.30486 ? 252  ARG A HG2  1 
ATOM   964  H HG3  . ARG A 1 72  ? -24.99729 20.04799  -13.93247 1.000 17.30486 ? 252  ARG A HG3  1 
ATOM   965  H HD2  . ARG A 1 72  ? -23.43311 18.41757  -15.59971 1.000 19.11762 ? 252  ARG A HD2  1 
ATOM   966  H HD3  . ARG A 1 72  ? -22.93978 19.81961  -15.03729 1.000 19.11762 ? 252  ARG A HD3  1 
ATOM   967  H HE   . ARG A 1 72  ? -23.61455 18.23281  -13.03305 1.000 17.76224 ? 252  ARG A HE   1 
ATOM   968  H HH11 . ARG A 1 72  ? -21.04451 18.63531  -15.07141 1.000 17.11123 ? 252  ARG A HH11 1 
ATOM   969  H HH12 . ARG A 1 72  ? -20.03680 18.01623  -14.16583 1.000 17.11123 ? 252  ARG A HH12 1 
ATOM   970  H HH21 . ARG A 1 72  ? -22.07679 17.28201  -11.70116 1.000 17.98971 ? 252  ARG A HH21 1 
ATOM   971  H HH22 . ARG A 1 72  ? -20.65411 17.19910  -12.13464 1.000 17.98971 ? 252  ARG A HH22 1 
ATOM   972  N N    . GLY A 1 73  ? -28.37877 19.09496  -12.41545 1.000 15.81133 ? 253  GLY A N    1 
ATOM   973  C CA   . GLY A 1 73  ? -28.80528 19.91502  -11.31447 1.000 17.95771 ? 253  GLY A CA   1 
ATOM   974  C C    . GLY A 1 73  ? -27.99899 19.76625  -10.04560 1.000 17.21823 ? 253  GLY A C    1 
ATOM   975  O O    . GLY A 1 73  ? -28.46267 20.19445  -8.97124  1.000 20.31127 ? 253  GLY A O    1 
ATOM   976  H H    . GLY A 1 73  ? -28.56500 18.25841  -12.34400 1.000 18.97359 ? 253  GLY A H    1 
ATOM   977  H HA2  . GLY A 1 73  ? -28.75674 20.84526  -11.58500 1.000 21.54925 ? 253  GLY A HA2  1 
ATOM   978  H HA3  . GLY A 1 73  ? -29.72622 19.69503  -11.10383 1.000 21.54925 ? 253  GLY A HA3  1 
ATOM   979  N N    . ASP A 1 74  ? -26.79929 19.21769  -10.14099 1.000 15.95907 ? 254  ASP A N    1 
ATOM   980  C CA   . ASP A 1 74  ? -25.93501 19.01862  -8.99575  1.000 14.46698 ? 254  ASP A CA   1 
ATOM   981  C C    . ASP A 1 74  ? -25.02557 20.21121  -8.75261  1.000 15.29439 ? 254  ASP A C    1 
ATOM   982  O O    . ASP A 1 74  ? -24.86049 21.10219  -9.60731  1.000 16.44387 ? 254  ASP A O    1 
ATOM   983  C CB   . ASP A 1 74  ? -25.12230 17.70394  -9.10806  1.000 16.76347 ? 254  ASP A CB   1 
ATOM   984  C CG   . ASP A 1 74  ? -24.33429 17.58114  -10.38665 1.000 15.76890 ? 254  ASP A CG   1 
ATOM   985  O OD1  . ASP A 1 74  ? -24.68311 18.20154  -11.41940 1.000 17.35665 ? 254  ASP A OD1  1 
ATOM   986  O OD2  . ASP A 1 74  ? -23.30258 16.87379  -10.32021 1.000 15.96053 ? 254  ASP A OD2  1 
ATOM   987  H H    . ASP A 1 74  ? -26.45470 18.94511  -10.88029 1.000 19.15089 ? 254  ASP A H    1 
ATOM   988  H HA   . ASP A 1 74  ? -26.49792 18.93414  -8.21032  1.000 17.36038 ? 254  ASP A HA   1 
ATOM   989  H HB2  . ASP A 1 74  ? -24.49496 17.66117  -8.36946  1.000 20.11617 ? 254  ASP A HB2  1 
ATOM   990  H HB3  . ASP A 1 74  ? -25.73570 16.95368  -9.06620  1.000 20.11617 ? 254  ASP A HB3  1 
ATOM   991  N N    . LYS A 1 75  ? -24.46609 20.23797  -7.54673  0.886 15.10540 ? 255  LYS A N    1 
ATOM   992  C CA   . LYS A 1 75  ? -23.49037 21.24226  -7.13756  0.886 13.89958 ? 255  LYS A CA   1 
ATOM   993  C C    . LYS A 1 75  ? -22.25800 20.48077  -6.64976  0.886 13.52092 ? 255  LYS A C    1 
ATOM   994  O O    . LYS A 1 75  ? -22.38436 19.44688  -5.98983  0.886 14.00966 ? 255  LYS A O    1 
ATOM   995  C CB   . LYS A 1 75  ? -24.06614 22.19725  -6.12281  0.886 18.30047 ? 255  LYS A CB   1 
ATOM   996  C CG   . LYS A 1 75  ? -24.64919 21.59227  -4.89957  0.886 21.87081 ? 255  LYS A CG   1 
ATOM   997  C CD   . LYS A 1 75  ? -25.30374 22.64725  -3.98317  0.886 22.37117 ? 255  LYS A CD   1 
ATOM   998  C CE   . LYS A 1 75  ? -26.65695 23.17481  -4.47144  0.886 23.35760 ? 255  LYS A CE   1 
ATOM   999  N NZ   . LYS A 1 75  ? -27.31773 24.14433  -3.53792  0.886 23.69023 ? 255  LYS A NZ   1 
ATOM   1000 H H    . LYS A 1 75  ? -24.64158 19.66632  -6.92865  0.886 18.12648 ? 255  LYS A H    1 
ATOM   1001 H HA   . LYS A 1 75  ? -23.21000 21.81472  -7.86872  0.886 16.67950 ? 255  LYS A HA   1 
ATOM   1002 H HB2  . LYS A 1 75  ? -23.35749 22.79374  -5.83485  0.886 21.96056 ? 255  LYS A HB2  1 
ATOM   1003 H HB3  . LYS A 1 75  ? -24.77212 22.70432  -6.55336  0.886 21.96056 ? 255  LYS A HB3  1 
ATOM   1004 H HG2  . LYS A 1 75  ? -25.32984 20.95008  -5.15494  0.886 26.24497 ? 255  LYS A HG2  1 
ATOM   1005 H HG3  . LYS A 1 75  ? -23.94729 21.14968  -4.39723  0.886 26.24497 ? 255  LYS A HG3  1 
ATOM   1006 H HD2  . LYS A 1 75  ? -25.44467 22.25137  -3.10892  0.886 26.84540 ? 255  LYS A HD2  1 
ATOM   1007 H HD3  . LYS A 1 75  ? -24.70487 23.40687  -3.91076  0.886 26.84540 ? 255  LYS A HD3  1 
ATOM   1008 H HE2  . LYS A 1 75  ? -26.52540 23.62797  -5.31892  0.886 28.02912 ? 255  LYS A HE2  1 
ATOM   1009 H HE3  . LYS A 1 75  ? -27.25914 22.42322  -4.58708  0.886 28.02912 ? 255  LYS A HE3  1 
ATOM   1010 H HZ1  . LYS A 1 75  ? -27.47052 23.75467  -2.75248  0.886 28.42827 ? 255  LYS A HZ1  1 
ATOM   1011 H HZ2  . LYS A 1 75  ? -28.09251 24.41702  -3.88064  0.886 28.42827 ? 255  LYS A HZ2  1 
ATOM   1012 H HZ3  . LYS A 1 75  ? -26.79261 24.85180  -3.41207  0.886 28.42827 ? 255  LYS A HZ3  1 
ATOM   1013 N N    . ILE A 1 76  ? -21.07653 20.94657  -7.04626  1.000 15.74406 ? 256  ILE A N    1 
ATOM   1014 C CA   . ILE A 1 76  ? -19.85613 20.16011  -6.94470  1.000 14.66789 ? 256  ILE A CA   1 
ATOM   1015 C C    . ILE A 1 76  ? -18.68849 21.00249  -6.45173  1.000 14.80596 ? 256  ILE A C    1 
ATOM   1016 O O    . ILE A 1 76  ? -18.71607 22.23277  -6.46154  1.000 17.41335 ? 256  ILE A O    1 
ATOM   1017 C CB   . ILE A 1 76  ? -19.52757 19.54665  -8.33343  1.000 15.37646 ? 256  ILE A CB   1 
ATOM   1018 C CG1  . ILE A 1 76  ? -19.06639 20.61506  -9.32617  1.000 18.78301 ? 256  ILE A CG1  1 
ATOM   1019 C CG2  . ILE A 1 76  ? -20.75610 18.84086  -8.91578  1.000 16.29502 ? 256  ILE A CG2  1 
ATOM   1020 C CD1  . ILE A 1 76  ? -17.59989 20.92827  -9.34430  1.000 19.79363 ? 256  ILE A CD1  1 
ATOM   1021 H H    . ILE A 1 76  ? -20.95707 21.72891  -7.38281  0.881 18.89287 ? 256  ILE A H    1 
ATOM   1022 H HA   . ILE A 1 76  ? -19.97193 19.46896  -6.27403  1.000 17.60146 ? 256  ILE A HA   1 
ATOM   1023 H HB   . ILE A 1 76  ? -18.80899 18.91007  -8.19447  1.000 18.45176 ? 256  ILE A HB   1 
ATOM   1024 H HG12 . ILE A 1 76  ? -19.30414 20.31875  -10.21868 1.000 22.53961 ? 256  ILE A HG12 1 
ATOM   1025 H HG13 . ILE A 1 76  ? -19.53015 21.44073  -9.11618  1.000 22.53961 ? 256  ILE A HG13 1 
ATOM   1026 H HG21 . ILE A 1 76  ? -20.48871 18.33776  -9.70082  1.000 19.55402 ? 256  ILE A HG21 1 
ATOM   1027 H HG22 . ILE A 1 76  ? -21.12209 18.24087  -8.24722  1.000 19.55402 ? 256  ILE A HG22 1 
ATOM   1028 H HG23 . ILE A 1 76  ? -21.41731 19.50743  -9.15946  1.000 19.55402 ? 256  ILE A HG23 1 
ATOM   1029 H HD11 . ILE A 1 76  ? -17.35199 21.22822  -10.23282 1.000 23.75236 ? 256  ILE A HD11 1 
ATOM   1030 H HD12 . ILE A 1 76  ? -17.41819 21.62709  -8.69658  1.000 23.75236 ? 256  ILE A HD12 1 
ATOM   1031 H HD13 . ILE A 1 76  ? -17.10305 20.12737  -9.11494  1.000 23.75236 ? 256  ILE A HD13 1 
ATOM   1032 N N    . THR A 1 77  ? -17.65046 20.29343  -5.98921  1.000 15.30029 ? 257  THR A N    1 
ATOM   1033 C CA   . THR A 1 77  ? -16.32413 20.89074  -5.82065  1.000 14.53394 ? 257  THR A CA   1 
ATOM   1034 C C    . THR A 1 77  ? -15.28838 19.84249  -6.17608  1.000 15.81131 ? 257  THR A C    1 
ATOM   1035 O O    . THR A 1 77  ? -15.56340 18.63751  -6.11004  1.000 15.85810 ? 257  THR A O    1 
ATOM   1036 C CB   . THR A 1 77  ? -16.15680 21.45899  -4.41145  1.000 17.85002 ? 257  THR A CB   1 
ATOM   1037 O OG1  . THR A 1 77  ? -14.95506 22.23523  -4.33877  1.000 20.52558 ? 257  THR A OG1  1 
ATOM   1038 C CG2  . THR A 1 77  ? -16.12127 20.35836  -3.39674  1.000 18.96918 ? 257  THR A CG2  1 
ATOM   1039 H H    . THR A 1 77  ? -17.69196 19.46378  -5.76662  1.000 18.36035 ? 257  THR A H    1 
ATOM   1040 H HA   . THR A 1 77  ? -16.18286 21.63336  -6.42848  1.000 17.44073 ? 257  THR A HA   1 
ATOM   1041 H HB   . THR A 1 77  ? -16.91183 22.03099  -4.20252  1.000 21.42002 ? 257  THR A HB   1 
ATOM   1042 H HG1  . THR A 1 77  ? -14.85853 22.54335  -3.56331  1.000 24.63070 ? 257  THR A HG1  1 
ATOM   1043 H HG21 . THR A 1 77  ? -16.20625 20.72752  -2.50377  1.000 22.76301 ? 257  THR A HG21 1 
ATOM   1044 H HG22 . THR A 1 77  ? -16.85202 19.73979  -3.55251  1.000 22.76301 ? 257  THR A HG22 1 
ATOM   1045 H HG23 . THR A 1 77  ? -15.28192 19.87623  -3.45950  1.000 22.76301 ? 257  THR A HG23 1 
ATOM   1046 N N    . TRP A 1 78  ? -14.10068 20.30103  -6.50972  1.000 16.81166 ? 258  TRP A N    1 
ATOM   1047 C CA   . TRP A 1 78  ? -12.99354 19.43249  -6.91482  1.000 15.01764 ? 258  TRP A CA   1 
ATOM   1048 C C    . TRP A 1 78  ? -12.01449 19.31070  -5.74951  1.000 15.16189 ? 258  TRP A C    1 
ATOM   1049 O O    . TRP A 1 78  ? -11.61882 20.30450  -5.15456  1.000 18.12063 ? 258  TRP A O    1 
ATOM   1050 C CB   . TRP A 1 78  ? -12.26033 20.01481  -8.12318  1.000 16.29434 ? 258  TRP A CB   1 
ATOM   1051 C CG   . TRP A 1 78  ? -13.12572 20.08766  -9.35340  1.000 14.37873 ? 258  TRP A CG   1 
ATOM   1052 C CD1  . TRP A 1 78  ? -13.79879 21.18933  -9.78049  1.000 15.37191 ? 258  TRP A CD1  1 
ATOM   1053 C CD2  . TRP A 1 78  ? -13.41990 19.03856  -10.27678 1.000 18.69212 ? 258  TRP A CD2  1 
ATOM   1054 N NE1  . TRP A 1 78  ? -14.49302 20.88483  -10.94211 1.000 16.48946 ? 258  TRP A NE1  1 
ATOM   1055 C CE2  . TRP A 1 78  ? -14.28423 19.57197  -11.26017 1.000 16.64837 ? 258  TRP A CE2  1 
ATOM   1056 C CE3  . TRP A 1 78  ? -13.03849 17.69101  -10.38622 1.000 15.62510 ? 258  TRP A CE3  1 
ATOM   1057 C CZ2  . TRP A 1 78  ? -14.77405 18.80835  -12.31813 1.000 17.58454 ? 258  TRP A CZ2  1 
ATOM   1058 C CZ3  . TRP A 1 78  ? -13.51039 16.95502  -11.43664 1.000 16.21395 ? 258  TRP A CZ3  1 
ATOM   1059 C CH2  . TRP A 1 78  ? -14.36822 17.51266  -12.40367 1.000 17.38759 ? 258  TRP A CH2  1 
ATOM   1060 H H    . TRP A 1 78  ? -13.89583 21.13627  -6.51238  1.000 20.17399 ? 258  TRP A H    1 
ATOM   1061 H HA   . TRP A 1 78  ? -13.33600 18.55561  -7.14870  1.000 18.02117 ? 258  TRP A HA   1 
ATOM   1062 H HB2  . TRP A 1 78  ? -11.96588 20.91414  -7.91011  1.000 19.55321 ? 258  TRP A HB2  1 
ATOM   1063 H HB3  . TRP A 1 78  ? -11.49511 19.45489  -8.32767  1.000 19.55321 ? 258  TRP A HB3  1 
ATOM   1064 H HD1  . TRP A 1 78  ? -13.79435 22.01837  -9.35910  1.000 18.44629 ? 258  TRP A HD1  1 
ATOM   1065 H HE1  . TRP A 1 78  ? -14.97806 21.43500  -11.39116 1.000 19.78735 ? 258  TRP A HE1  1 
ATOM   1066 H HE3  . TRP A 1 78  ? -12.47452 17.30631  -9.75468  1.000 18.75012 ? 258  TRP A HE3  1 
ATOM   1067 H HZ2  . TRP A 1 78  ? -15.35809 19.17190  -12.94393 1.000 21.10145 ? 258  TRP A HZ2  1 
ATOM   1068 H HZ3  . TRP A 1 78  ? -13.25845 16.06320  -11.51460 1.000 19.45674 ? 258  TRP A HZ3  1 
ATOM   1069 H HH2  . TRP A 1 78  ? -14.66216 16.98692  -13.11226 1.000 20.86511 ? 258  TRP A HH2  1 
ATOM   1070 N N    . ILE A 1 79  ? -11.64085 18.07538  -5.44473  1.000 16.08844 ? 259  ILE A N    1 
ATOM   1071 C CA   . ILE A 1 79  ? -10.78279 17.74557  -4.29960  1.000 15.83757 ? 259  ILE A CA   1 
ATOM   1072 C C    . ILE A 1 79  ? -9.55104  17.00330  -4.79676  1.000 17.12609 ? 259  ILE A C    1 
ATOM   1073 O O    . ILE A 1 79  ? -9.67288  15.99002  -5.50596  1.000 16.24670 ? 259  ILE A O    1 
ATOM   1074 C CB   . ILE A 1 79  ? -11.56367 16.86343  -3.28861  1.000 16.67777 ? 259  ILE A CB   1 
ATOM   1075 C CG1  . ILE A 1 79  ? -12.72658 17.65787  -2.68009  1.000 20.31864 ? 259  ILE A CG1  1 
ATOM   1076 C CG2  . ILE A 1 79  ? -10.61455 16.29796  -2.25499  1.000 20.23905 ? 259  ILE A CG2  1 
ATOM   1077 C CD1  . ILE A 1 79  ? -12.33017 18.86078  -1.91001  1.000 26.66653 ? 259  ILE A CD1  1 
ATOM   1078 H H    . ILE A 1 79  ? -11.87667 17.38384  -5.89834  1.000 19.30613 ? 259  ILE A H    1 
ATOM   1079 H HA   . ILE A 1 79  ? -10.48336 18.56250  -3.87081  1.000 19.00509 ? 259  ILE A HA   1 
ATOM   1080 H HB   . ILE A 1 79  ? -11.95992 16.10646  -3.74783  1.000 20.01333 ? 259  ILE A HB   1 
ATOM   1081 H HG12 . ILE A 1 79  ? -13.30704 17.95179  -3.39952  1.000 24.38237 ? 259  ILE A HG12 1 
ATOM   1082 H HG13 . ILE A 1 79  ? -13.21429 17.07488  -2.07746  1.000 24.38237 ? 259  ILE A HG13 1 
ATOM   1083 H HG21 . ILE A 1 79  ? -11.12359 16.01942  -1.47770  1.000 24.28686 ? 259  ILE A HG21 1 
ATOM   1084 H HG22 . ILE A 1 79  ? -10.14964 15.53671  -2.63611  1.000 24.28686 ? 259  ILE A HG22 1 
ATOM   1085 H HG23 . ILE A 1 79  ? -9.97606  16.98367  -2.00391  1.000 24.28686 ? 259  ILE A HG23 1 
ATOM   1086 H HD11 . ILE A 1 79  ? -13.05509 19.10769  -1.31467  1.000 31.99983 ? 259  ILE A HD11 1 
ATOM   1087 H HD12 . ILE A 1 79  ? -11.53371 18.65772  -1.39493  1.000 31.99983 ? 259  ILE A HD12 1 
ATOM   1088 H HD13 . ILE A 1 79  ? -12.14835 19.58579  -2.52824  1.000 31.99983 ? 259  ILE A HD13 1 
ATOM   1089 N N    . GLU A 1 80  ? -8.37566  17.48562  -4.38249  1.000 17.00112 ? 260  GLU A N    1 
ATOM   1090 C CA   A GLU A 1 80  ? -7.09036  16.89325  -4.77152  1.000 21.29717 ? 260  GLU A CA   1 
ATOM   1091 C CA   B GLU A 1 80  ? -7.10737  16.88702  -4.77894  0.000 21.44022 ? 260  GLU A CA   1 
ATOM   1092 C C    . GLU A 1 80  ? -6.73157  15.71555  -3.88256  1.000 26.91668 ? 260  GLU A C    1 
ATOM   1093 O O    . GLU A 1 80  ? -6.02794  14.80152  -4.33260  1.000 26.93421 ? 260  GLU A O    1 
ATOM   1094 C CB   A GLU A 1 80  ? -5.98038  17.96347  -4.71943  1.000 26.53830 ? 260  GLU A CB   1 
ATOM   1095 C CB   B GLU A 1 80  ? -6.00104  17.94289  -4.70980  0.000 26.37451 ? 260  GLU A CB   1 
ATOM   1096 C CG   A GLU A 1 80  ? -4.51367  17.54019  -5.02169  1.000 34.11929 ? 260  GLU A CG   1 
ATOM   1097 C CG   B GLU A 1 80  ? -6.25844  19.17086  -5.56204  0.000 25.02760 ? 260  GLU A CG   1 
ATOM   1098 H H    A GLU A 1 80  ? -8.29158  18.16791  -3.86575  1.000 20.40135 ? 260  GLU A H    1 
ATOM   1099 H H    B GLU A 1 80  ? -8.28784  18.16697  -3.86515  0.000 20.40135 ? 260  GLU A H    1 
ATOM   1100 H HA   A GLU A 1 80  ? -7.14714  16.57416  -5.68577  1.000 25.55660 ? 260  GLU A HA   1 
ATOM   1101 H HA   B GLU A 1 80  ? -7.18206  16.56681  -5.69151  0.000 25.72827 ? 260  GLU A HA   1 
ATOM   1102 H HB2  A GLU A 1 80  ? -6.20633  18.64987  -5.36650  1.000 31.84596 ? 260  GLU A HB2  1 
ATOM   1103 H HB2  B GLU A 1 80  ? -5.91033  18.23702  -3.78993  0.000 31.64941 ? 260  GLU A HB2  1 
ATOM   1104 H HB3  A GLU A 1 80  ? -5.97849  18.33854  -3.82489  1.000 31.84596 ? 260  GLU A HB3  1 
ATOM   1105 H HB3  B GLU A 1 80  ? -5.17126  17.54274  -5.01352  0.000 31.64941 ? 260  GLU A HB3  1 
ATOM   1106 N N    . GLY A 1 81  ? -7.20389  15.72042  -2.63387  1.000 25.65598 ? 261  GLY A N    1 
ATOM   1107 C CA   . GLY A 1 81  ? -6.98457  14.64745  -1.67758  1.000 25.22559 ? 261  GLY A CA   1 
ATOM   1108 C C    . GLY A 1 81  ? -6.15404  15.03632  -0.47742  1.000 26.00084 ? 261  GLY A C    1 
ATOM   1109 O O    . GLY A 1 81  ? -6.21896  14.35408  0.55823   1.000 26.29624 ? 261  GLY A O    1 
ATOM   1110 H H    . GLY A 1 81  ? -7.67318  16.36408  -2.30973  1.000 30.78718 ? 261  GLY A H    1 
ATOM   1111 H HA2  . GLY A 1 81  ? -7.84483  14.33626  -1.35508  1.000 30.27071 ? 261  GLY A HA2  1 
ATOM   1112 H HA3  . GLY A 1 81  ? -6.53256  13.91638  -2.12715  1.000 30.27071 ? 261  GLY A HA3  1 
ATOM   1113 N N    . LYS A 1 82  ? -5.37696  16.10281  -0.56870  1.000 28.28764 ? 262  LYS A N    1 
ATOM   1114 C CA   . LYS A 1 82  ? -4.47406  16.49255  0.50439   1.000 30.31723 ? 262  LYS A CA   1 
ATOM   1115 C C    . LYS A 1 82  ? -4.99925  17.65902  1.32699   1.000 25.01107 ? 262  LYS A C    1 
ATOM   1116 O O    . LYS A 1 82  ? -4.30577  18.11406  2.24846   1.000 30.80791 ? 262  LYS A O    1 
ATOM   1117 C CB   . LYS A 1 82  ? -3.10309  16.84931  -0.08023  1.000 40.45534 ? 262  LYS A CB   1 
ATOM   1118 C CG   . LYS A 1 82  ? -2.35881  15.66288  -0.69912  1.000 47.50455 ? 262  LYS A CG   1 
ATOM   1119 C CD   . LYS A 1 82  ? -0.93700  16.04310  -1.13143  1.000 53.28287 ? 262  LYS A CD   1 
ATOM   1120 C CE   . LYS A 1 82  ? -0.20357  14.86624  -1.77093  1.000 50.35922 ? 262  LYS A CE   1 
ATOM   1121 H H    . LYS A 1 82  ? -5.35326  16.62519  -1.25146  1.000 33.94517 ? 262  LYS A H    1 
ATOM   1122 H HA   . LYS A 1 82  ? -4.35999  15.74008  1.10579   1.000 36.38067 ? 262  LYS A HA   1 
ATOM   1123 H HB2  . LYS A 1 82  ? -3.22563  17.51505  -0.77498  1.000 48.54641 ? 262  LYS A HB2  1 
ATOM   1124 H HB3  . LYS A 1 82  ? -2.54714  17.20833  0.62894   1.000 48.54641 ? 262  LYS A HB3  1 
ATOM   1125 H HG2  . LYS A 1 82  ? -2.29640  14.94844  -0.04599  1.000 57.00546 ? 262  LYS A HG2  1 
ATOM   1126 H HG3  . LYS A 1 82  ? -2.84187  15.35537  -1.48206  1.000 57.00546 ? 262  LYS A HG3  1 
ATOM   1127 H HD2  . LYS A 1 82  ? -0.98159  16.76199  -1.78112  1.000 63.93945 ? 262  LYS A HD2  1 
ATOM   1128 H HD3  . LYS A 1 82  ? -0.43199  16.32915  -0.35424  1.000 63.93945 ? 262  LYS A HD3  1 
ATOM   1129 N N    . GLU A 1 83  ? -6.20135  18.15226  1.04174   1.000 27.48710 ? 263  GLU A N    1 
ATOM   1130 C CA   . GLU A 1 83  ? -6.67455  19.33503  1.73350   1.000 28.80066 ? 263  GLU A CA   1 
ATOM   1131 C C    . GLU A 1 83  ? -7.03643  19.00163  3.18393   1.000 28.35373 ? 263  GLU A C    1 
ATOM   1132 O O    . GLU A 1 83  ? -7.54457  17.90478  3.46921   1.000 27.77700 ? 263  GLU A O    1 
ATOM   1133 C CB   . GLU A 1 83  ? -7.92261  19.85420  1.04571   1.000 26.86485 ? 263  GLU A CB   1 
ATOM   1134 C CG   . GLU A 1 83  ? -7.76058  20.33612  -0.39940  1.000 27.30668 ? 263  GLU A CG   1 
ATOM   1135 C CD   . GLU A 1 83  ? -8.01613  19.24933  -1.44701  1.000 23.25120 ? 263  GLU A CD   1 
ATOM   1136 O OE1  . GLU A 1 83  ? -7.95223  18.04179  -1.13124  1.000 22.17270 ? 263  GLU A OE1  1 
ATOM   1137 O OE2  . GLU A 1 83  ? -8.34402  19.60055  -2.60416  1.000 22.78680 ? 263  GLU A OE2  1 
ATOM   1138 H H    . GLU A 1 83  ? -6.74726  17.82467  0.46359   1.000 32.98452 ? 263  GLU A H    1 
ATOM   1139 H HA   . GLU A 1 83  ? -5.98085  20.01301  1.72825   1.000 34.56079 ? 263  GLU A HA   1 
ATOM   1140 H HB2  . GLU A 1 83  ? -8.57887  19.13999  1.03473   1.000 32.23783 ? 263  GLU A HB2  1 
ATOM   1141 H HB3  . GLU A 1 83  ? -8.25839  20.60542  1.55936   1.000 32.23783 ? 263  GLU A HB3  1 
ATOM   1142 H HG2  . GLU A 1 83  ? -8.39076  21.05567  -0.56068  1.000 32.76802 ? 263  GLU A HG2  1 
ATOM   1143 H HG3  . GLU A 1 83  ? -6.85311  20.65629  -0.52146  1.000 32.76802 ? 263  GLU A HG3  1 
ATOM   1144 N N    . PRO A 1 84  ? -6.78830  19.92007  4.11693   1.000 32.32704 ? 264  PRO A N    1 
ATOM   1145 C CA   . PRO A 1 84  ? -7.23685  19.68089  5.49679   1.000 34.45854 ? 264  PRO A CA   1 
ATOM   1146 C C    . PRO A 1 84  ? -8.74086  19.44878  5.52893   1.000 33.41421 ? 264  PRO A C    1 
ATOM   1147 O O    . PRO A 1 84  ? -9.51585  20.16668  4.89207   1.000 33.92078 ? 264  PRO A O    1 
ATOM   1148 C CB   . PRO A 1 84  ? -6.84993  20.96730  6.24353   1.000 49.31927 ? 264  PRO A CB   1 
ATOM   1149 C CG   . PRO A 1 84  ? -6.07719  21.81763  5.28892   1.000 49.39040 ? 264  PRO A CG   1 
ATOM   1150 C CD   . PRO A 1 84  ? -5.87571  21.07395  4.00179   1.000 38.11137 ? 264  PRO A CD   1 
ATOM   1151 H HA   . PRO A 1 84  ? -6.76515  18.92951  5.88901   1.000 41.35025 ? 264  PRO A HA   1 
ATOM   1152 H HB2  . PRO A 1 84  ? -7.65481  21.42602  6.53102   1.000 59.18313 ? 264  PRO A HB2  1 
ATOM   1153 H HB3  . PRO A 1 84  ? -6.30471  20.74018  7.01298   1.000 59.18313 ? 264  PRO A HB3  1 
ATOM   1154 H HG2  . PRO A 1 84  ? -6.57596  22.63303  5.12386   1.000 59.26847 ? 264  PRO A HG2  1 
ATOM   1155 H HG3  . PRO A 1 84  ? -5.21757  22.02906  5.68546   1.000 59.26847 ? 264  PRO A HG3  1 
ATOM   1156 H HD2  . PRO A 1 84  ? -6.11701  21.62839  3.24333   1.000 45.73364 ? 264  PRO A HD2  1 
ATOM   1157 H HD3  . PRO A 1 84  ? -4.95607  20.77741  3.91673   1.000 45.73364 ? 264  PRO A HD3  1 
ATOM   1158 N N    . GLY A 1 85  ? -9.15588  18.42848  6.27797   1.000 32.72623 ? 265  GLY A N    1 
ATOM   1159 C CA   . GLY A 1 85  ? -10.57020 18.12307  6.35463   1.000 28.69564 ? 265  GLY A CA   1 
ATOM   1160 C C    . GLY A 1 85  ? -11.09087 17.24132  5.24763   1.000 30.29620 ? 265  GLY A C    1 
ATOM   1161 O O    . GLY A 1 85  ? -12.29245 16.94113  5.23261   1.000 33.02416 ? 265  GLY A O    1 
ATOM   1162 H H    . GLY A 1 85  ? -8.64408  17.91331  6.73868   1.000 39.27148 ? 265  GLY A H    1 
ATOM   1163 H HA2  . GLY A 1 85  ? -10.74563 17.67488  7.19680   1.000 34.43477 ? 265  GLY A HA2  1 
ATOM   1164 H HA3  . GLY A 1 85  ? -11.06899 18.95462  6.32954   1.000 34.43477 ? 265  GLY A HA3  1 
ATOM   1165 N N    . CYS A 1 86  ? -10.22992 16.82833  4.30029   1.000 27.16010 ? 266  CYS A N    1 
ATOM   1166 C CA   . CYS A 1 86  ? -10.58550 15.89616  3.24696   1.000 24.97908 ? 266  CYS A CA   1 
ATOM   1167 C C    . CYS A 1 86  ? -9.71953  14.64376  3.29879   1.000 22.92943 ? 266  CYS A C    1 
ATOM   1168 O O    . CYS A 1 86  ? -9.55842  13.95654  2.28929   1.000 20.92999 ? 266  CYS A O    1 
ATOM   1169 C CB   . CYS A 1 86  ? -10.45236 16.58640  1.89355   1.000 21.08724 ? 266  CYS A CB   1 
ATOM   1170 S SG   . CYS A 1 86  ? -11.65212 17.93965  1.70780   1.000 28.78120 ? 266  CYS A SG   1 
ATOM   1171 H H    . CYS A 1 86  ? -9.41167  17.08929  4.25596   1.000 32.59212 ? 266  CYS A H    1 
ATOM   1172 H HA   . CYS A 1 86  ? -11.50786 15.61616  3.35530   1.000 29.97490 ? 266  CYS A HA   1 
ATOM   1173 H HB2  . CYS A 1 86  ? -9.55974  16.95674  1.81010   1.000 25.30469 ? 266  CYS A HB2  1 
ATOM   1174 H HB3  . CYS A 1 86  ? -10.61054 15.93974  1.18806   1.000 25.30469 ? 266  CYS A HB3  1 
ATOM   1175 H HG   . CYS A 1 86  ? -11.36954 18.58137  0.73397   1.000 34.53744 ? 266  CYS A HG   1 
ATOM   1176 N N    . GLU A 1 87  ? -9.15694  14.32109  4.45854   1.000 24.71718 ? 267  GLU A N    1 
ATOM   1177 C CA   . GLU A 1 87  ? -8.18008  13.23057  4.51836   1.000 22.84589 ? 267  GLU A CA   1 
ATOM   1178 C C    . GLU A 1 87  ? -8.79856  11.88726  4.15508   1.000 24.84200 ? 267  GLU A C    1 
ATOM   1179 O O    . GLU A 1 87  ? -8.14300  11.03551  3.53150   1.000 23.17022 ? 267  GLU A O    1 
ATOM   1180 C CB   . GLU A 1 87  ? -7.57942  13.15352  5.92746   1.000 32.68284 ? 267  GLU A CB   1 
ATOM   1181 C CG   . GLU A 1 87  ? -6.65779  14.30642  6.31959   1.000 30.86274 ? 267  GLU A CG   1 
ATOM   1182 C CD   . GLU A 1 87  ? -7.38567  15.53818  6.82417   1.000 28.22846 ? 267  GLU A CD   1 
ATOM   1183 O OE1  . GLU A 1 87  ? -8.63244  15.52084  6.91430   1.000 34.37238 ? 267  GLU A OE1  1 
ATOM   1184 O OE2  . GLU A 1 87  ? -6.69302  16.53916  7.14909   1.000 36.90204 ? 267  GLU A OE2  1 
ATOM   1185 H H    . GLU A 1 87  ? -9.31680  14.70630  5.21064   1.000 29.66062 ? 267  GLU A H    1 
ATOM   1186 H HA   . GLU A 1 87  ? -7.47643  13.42009  3.87816   1.000 27.41506 ? 267  GLU A HA   1 
ATOM   1187 H HB2  . GLU A 1 87  ? -8.30770  13.13685  6.56795   1.000 39.21941 ? 267  GLU A HB2  1 
ATOM   1188 H HB3  . GLU A 1 87  ? -7.06132  12.33609  5.99286   1.000 39.21941 ? 267  GLU A HB3  1 
ATOM   1189 H HG2  . GLU A 1 87  ? -6.06580  14.00456  7.02623   1.000 37.03529 ? 267  GLU A HG2  1 
ATOM   1190 H HG3  . GLU A 1 87  ? -6.13999  14.56856  5.54238   1.000 37.03529 ? 267  GLU A HG3  1 
ATOM   1191 N N    . THR A 1 88  ? -10.04473 11.64120  4.58564   1.000 21.95019 ? 268  THR A N    1 
ATOM   1192 C CA   . THR A 1 88  ? -10.66783 10.35631  4.25736   1.000 21.60607 ? 268  THR A CA   1 
ATOM   1193 C C    . THR A 1 88  ? -11.09637 10.30677  2.80500   1.000 20.11768 ? 268  THR A C    1 
ATOM   1194 O O    . THR A 1 88  ? -11.02762 9.24274   2.17888   1.000 19.29431 ? 268  THR A O    1 
ATOM   1195 C CB   . THR A 1 88  ? -11.84061 10.06939  5.19576   1.000 21.49582 ? 268  THR A CB   1 
ATOM   1196 O OG1  . THR A 1 88  ? -11.51388 10.52705  6.52571   1.000 25.89108 ? 268  THR A OG1  1 
ATOM   1197 C CG2  . THR A 1 88  ? -12.13402 8.55953   5.29379   1.000 21.76886 ? 268  THR A CG2  1 
ATOM   1198 H H    . THR A 1 88  ? -10.52835 12.18018  5.04956   1.000 26.34022 ? 268  THR A H    1 
ATOM   1199 H HA   . THR A 1 88  ? -10.02570 9.64328   4.39934   1.000 25.92729 ? 268  THR A HA   1 
ATOM   1200 H HB   . THR A 1 88  ? -12.62432 10.52264  4.84752   1.000 25.79498 ? 268  THR A HB   1 
ATOM   1201 H HG1  . THR A 1 88  ? -11.50647 11.36676  6.54686   1.000 31.06929 ? 268  THR A HG1  1 
ATOM   1202 H HG21 . THR A 1 88  ? -12.93847 8.41105   5.81505   1.000 26.12263 ? 268  THR A HG21 1 
ATOM   1203 H HG22 . THR A 1 88  ? -12.26059 8.18789   4.40679   1.000 26.12263 ? 268  THR A HG22 1 
ATOM   1204 H HG23 . THR A 1 88  ? -11.39247 8.10464   5.72283   1.000 26.12263 ? 268  THR A HG23 1 
ATOM   1205 N N    . ILE A 1 89  ? -11.52052 11.44289  2.22864   1.000 18.72980 ? 269  ILE A N    1 
ATOM   1206 C CA   . ILE A 1 89  ? -11.69787 11.48931  0.78221   1.000 18.57937 ? 269  ILE A CA   1 
ATOM   1207 C C    . ILE A 1 89  ? -10.38695 11.12454  0.08395   1.000 15.61529 ? 269  ILE A C    1 
ATOM   1208 O O    . ILE A 1 89  ? -10.38026 10.38262  -0.90774  1.000 16.33085 ? 269  ILE A O    1 
ATOM   1209 C CB   . ILE A 1 89  ? -12.25115 12.86460  0.33331   1.000 16.71311 ? 269  ILE A CB   1 
ATOM   1210 C CG1  . ILE A 1 89  ? -13.65122 13.07862  0.90997   1.000 19.50552 ? 269  ILE A CG1  1 
ATOM   1211 C CG2  . ILE A 1 89  ? -12.33917 12.94289  -1.16410  1.000 19.41360 ? 269  ILE A CG2  1 
ATOM   1212 C CD1  . ILE A 1 89  ? -14.18693 14.50343  0.74486   1.000 19.69807 ? 269  ILE A CD1  1 
ATOM   1213 H H    . ILE A 1 89  ? -11.70464 12.17286  2.64437   1.000 22.47576 ? 269  ILE A H    1 
ATOM   1214 H HA   . ILE A 1 89  ? -12.36194 10.82930  0.52862   1.000 22.29524 ? 269  ILE A HA   1 
ATOM   1215 H HB   . ILE A 1 89  ? -11.64357 13.54667  0.65968   1.000 20.05573 ? 269  ILE A HB   1 
ATOM   1216 H HG12 . ILE A 1 89  ? -14.26688 12.47891  0.46031   1.000 23.40662 ? 269  ILE A HG12 1 
ATOM   1217 H HG13 . ILE A 1 89  ? -13.62921 12.88080  1.85933   1.000 23.40662 ? 269  ILE A HG13 1 
ATOM   1218 H HG21 . ILE A 1 89  ? -12.82642 13.74469  -1.41031  1.000 23.29632 ? 269  ILE A HG21 1 
ATOM   1219 H HG22 . ILE A 1 89  ? -11.44219 12.97486  -1.53194  1.000 23.29632 ? 269  ILE A HG22 1 
ATOM   1220 H HG23 . ILE A 1 89  ? -12.80443 12.15852  -1.49454  1.000 23.29632 ? 269  ILE A HG23 1 
ATOM   1221 H HD11 . ILE A 1 89  ? -14.97143 14.61272  1.30479   1.000 23.63768 ? 269  ILE A HD11 1 
ATOM   1222 H HD12 . ILE A 1 89  ? -13.49898 15.13253  1.01293   1.000 23.63768 ? 269  ILE A HD12 1 
ATOM   1223 H HD13 . ILE A 1 89  ? -14.42187 14.64667  -0.18529  1.000 23.63768 ? 269  ILE A HD13 1 
ATOM   1224 N N    . GLY A 1 90  ? -9.26966  11.61380  0.59812   1.000 19.09675 ? 270  GLY A N    1 
ATOM   1225 C CA   . GLY A 1 90  ? -7.98274  11.24485  0.03451   1.000 20.43229 ? 270  GLY A CA   1 
ATOM   1226 C C    . GLY A 1 90  ? -7.72115  9.76063   0.12426   1.000 18.08802 ? 270  GLY A C    1 
ATOM   1227 O O    . GLY A 1 90  ? -7.16785  9.16665   -0.80047  1.000 18.82572 ? 270  GLY A O    1 
ATOM   1228 H H    . GLY A 1 90  ? -9.22825  12.15484  1.26532   1.000 22.91610 ? 270  GLY A H    1 
ATOM   1229 H HA2  . GLY A 1 90  ? -7.95495  11.50445  -0.89970  1.000 24.51875 ? 270  GLY A HA2  1 
ATOM   1230 H HA3  . GLY A 1 90  ? -7.27782  11.70919  0.51241   1.000 24.51875 ? 270  GLY A HA3  1 
ATOM   1231 N N    . LEU A 1 91  ? -8.11117  9.14674   1.24955   1.000 19.60303 ? 271  LEU A N    1 
ATOM   1232 C CA   . LEU A 1 91  ? -7.94755  7.69736   1.37710   1.000 19.51576 ? 271  LEU A CA   1 
ATOM   1233 C C    . LEU A 1 91  ? -8.79877  6.96593   0.35264   1.000 18.71293 ? 271  LEU A C    1 
ATOM   1234 O O    . LEU A 1 91  ? -8.36191  5.96657   -0.24290  1.000 18.77436 ? 271  LEU A O    1 
ATOM   1235 C CB   . LEU A 1 91  ? -8.28336  7.23239   2.79509   1.000 22.31740 ? 271  LEU A CB   1 
ATOM   1236 C CG   . LEU A 1 91  ? -8.39827  5.72453   3.04003   1.000 23.64269 ? 271  LEU A CG   1 
ATOM   1237 C CD1  . LEU A 1 91  ? -7.08312  4.98564   2.81518   1.000 28.28581 ? 271  LEU A CD1  1 
ATOM   1238 C CD2  . LEU A 1 91  ? -8.91055  5.42427   4.46751   1.000 28.47839 ? 271  LEU A CD2  1 
ATOM   1239 H H    . LEU A 1 91  ? -8.46216  9.53580   1.93149   1.000 23.52363 ? 271  LEU A H    1 
ATOM   1240 H HA   . LEU A 1 91  ? -7.01679  7.47584   1.21736   1.000 23.41892 ? 271  LEU A HA   1 
ATOM   1241 H HB2  . LEU A 1 91  ? -7.58777  7.56002   3.38647   1.000 26.78088 ? 271  LEU A HB2  1 
ATOM   1242 H HB3  . LEU A 1 91  ? -9.13741  7.62179   3.03975   1.000 26.78088 ? 271  LEU A HB3  1 
ATOM   1243 H HG   . LEU A 1 91  ? -9.03843  5.39152   2.39181   1.000 28.37122 ? 271  LEU A HG   1 
ATOM   1244 H HD11 . LEU A 1 91  ? -7.21746  4.04120   2.99093   1.000 33.94297 ? 271  LEU A HD11 1 
ATOM   1245 H HD12 . LEU A 1 91  ? -6.80181  5.11427   1.89582   1.000 33.94297 ? 271  LEU A HD12 1 
ATOM   1246 H HD13 . LEU A 1 91  ? -6.41316  5.34246   3.41910   1.000 33.94297 ? 271  LEU A HD13 1 
ATOM   1247 H HD21 . LEU A 1 91  ? -8.96499  4.46331   4.58788   1.000 34.17407 ? 271  LEU A HD21 1 
ATOM   1248 H HD22 . LEU A 1 91  ? -8.29214  5.80376   5.11130   1.000 34.17407 ? 271  LEU A HD22 1 
ATOM   1249 H HD23 . LEU A 1 91  ? -9.78844  5.82175   4.57811   1.000 34.17407 ? 271  LEU A HD23 1 
ATOM   1250 N N    . LEU A 1 92  ? -10.02531 7.44518   0.12494   1.000 17.72526 ? 272  LEU A N    1 
ATOM   1251 C CA   . LEU A 1 92  ? -10.84643 6.84675   -0.90745  1.000 16.35912 ? 272  LEU A CA   1 
ATOM   1252 C C    . LEU A 1 92  ? -10.14670 6.93006   -2.26008  1.000 15.56581 ? 272  LEU A C    1 
ATOM   1253 O O    . LEU A 1 92  ? -10.11572 5.94869   -3.00926  1.000 15.51727 ? 272  LEU A O    1 
ATOM   1254 C CB   . LEU A 1 92  ? -12.17706 7.60069   -0.98465  1.000 17.70519 ? 272  LEU A CB   1 
ATOM   1255 C CG   . LEU A 1 92  ? -13.08524 7.36315   -2.19978  1.000 16.34274 ? 272  LEU A CG   1 
ATOM   1256 C CD1  . LEU A 1 92  ? -13.61736 5.91544   -2.24010  1.000 17.46841 ? 272  LEU A CD1  1 
ATOM   1257 C CD2  . LEU A 1 92  ? -14.20433 8.44248   -2.28804  1.000 17.80716 ? 272  LEU A CD2  1 
ATOM   1258 H H    . LEU A 1 92  ? -10.38919 8.09969   0.54780   1.000 21.27031 ? 272  LEU A H    1 
ATOM   1259 H HA   . LEU A 1 92  ? -11.01039 5.91594   -0.68924  1.000 19.63095 ? 272  LEU A HA   1 
ATOM   1260 H HB2  . LEU A 1 92  ? -12.69553 7.35975   -0.20104  1.000 21.24623 ? 272  LEU A HB2  1 
ATOM   1261 H HB3  . LEU A 1 92  ? -11.97665 8.54966   -0.97094  1.000 21.24623 ? 272  LEU A HB3  1 
ATOM   1262 H HG   . LEU A 1 92  ? -12.55926 7.46352   -3.00859  1.000 19.61128 ? 272  LEU A HG   1 
ATOM   1263 H HD11 . LEU A 1 92  ? -14.18635 5.80968   -3.01854  1.000 20.96210 ? 272  LEU A HD11 1 
ATOM   1264 H HD12 . LEU A 1 92  ? -12.86608 5.30423   -2.29403  1.000 20.96210 ? 272  LEU A HD12 1 
ATOM   1265 H HD13 . LEU A 1 92  ? -14.12638 5.74346   -1.43250  1.000 20.96210 ? 272  LEU A HD13 1 
ATOM   1266 H HD21 . LEU A 1 92  ? -14.74061 8.27739   -3.07927  1.000 21.36859 ? 272  LEU A HD21 1 
ATOM   1267 H HD22 . LEU A 1 92  ? -14.75963 8.38725   -1.49463  1.000 21.36859 ? 272  LEU A HD22 1 
ATOM   1268 H HD23 . LEU A 1 92  ? -13.79358 9.31944   -2.34391  1.000 21.36859 ? 272  LEU A HD23 1 
ATOM   1269 N N    . MET A 1 93  ? -9.60005  8.10202   -2.58461  1.000 14.89857 ? 273  MET A N    1 
ATOM   1270 C CA   . MET A 1 93  ? -8.96525  8.32056   -3.87650  1.000 14.72108 ? 273  MET A CA   1 
ATOM   1271 C C    . MET A 1 93  ? -7.77514  7.37758   -4.01612  1.000 14.92710 ? 273  MET A C    1 
ATOM   1272 O O    . MET A 1 93  ? -7.57632  6.73795   -5.04556  1.000 15.40095 ? 273  MET A O    1 
ATOM   1273 C CB   . MET A 1 93  ? -8.51903  9.76292   -3.82524  1.000 17.08386 ? 273  MET A CB   1 
ATOM   1274 C CG   . MET A 1 93  ? -9.74148  10.71479  -3.99586  1.000 17.27355 ? 273  MET A CG   1 
ATOM   1275 S SD   . MET A 1 93  ? -9.28908  12.44814  -3.94001  1.000 17.28071 ? 273  MET A SD   1 
ATOM   1276 C CE   . MET A 1 93  ? -8.58704  12.73169  -5.50179  1.000 16.81191 ? 273  MET A CE   1 
ATOM   1277 H H    . MET A 1 93  ? -9.58442  8.79041   -2.06937  1.000 17.87829 ? 273  MET A H    1 
ATOM   1278 H HA   . MET A 1 93  ? -9.55166  8.16915   -4.63420  1.000 17.66530 ? 273  MET A HA   1 
ATOM   1279 H HB2  . MET A 1 93  ? -8.10192  9.94371   -2.96836  1.000 20.50063 ? 273  MET A HB2  1 
ATOM   1280 H HB3  . MET A 1 93  ? -7.88967  9.93401   -4.54325  1.000 20.50063 ? 273  MET A HB3  1 
ATOM   1281 H HG2  . MET A 1 93  ? -10.15863 10.54182  -4.85432  1.000 20.72826 ? 273  MET A HG2  1 
ATOM   1282 H HG3  . MET A 1 93  ? -10.37409 10.54732  -3.27985  1.000 20.72826 ? 273  MET A HG3  1 
ATOM   1283 H HE1  . MET A 1 93  ? -8.32406  13.66319  -5.56542  1.000 20.17429 ? 273  MET A HE1  1 
ATOM   1284 H HE2  . MET A 1 93  ? -7.81002  12.16068  -5.60714  1.000 20.17429 ? 273  MET A HE2  1 
ATOM   1285 H HE3  . MET A 1 93  ? -9.24382  12.52597  -6.18532  1.000 20.17429 ? 273  MET A HE3  1 
ATOM   1286 N N    A SER A 1 94  ? -6.98615  7.23550   -2.95886  0.414 16.27585 ? 274  SER A N    1 
ATOM   1287 N N    B SER A 1 94  ? -6.99130  7.24188   -2.94694  0.586 16.21551 ? 274  SER A N    1 
ATOM   1288 C CA   A SER A 1 94  ? -5.83993  6.33300   -3.04852  0.414 16.99661 ? 274  SER A CA   1 
ATOM   1289 C CA   B SER A 1 94  ? -5.84313  6.33175   -2.95969  0.586 16.92496 ? 274  SER A CA   1 
ATOM   1290 C C    A SER A 1 94  ? -6.28247  4.87228   -3.16491  0.414 16.42240 ? 274  SER A C    1 
ATOM   1291 C C    B SER A 1 94  ? -6.27945  4.87933   -3.13895  0.586 16.41079 ? 274  SER A C    1 
ATOM   1292 O O    A SER A 1 94  ? -5.62364  4.08704   -3.85166  0.414 16.93186 ? 274  SER A O    1 
ATOM   1293 O O    B SER A 1 94  ? -5.61850  4.11623   -3.84782  0.586 16.87795 ? 274  SER A O    1 
ATOM   1294 C CB   A SER A 1 94  ? -4.86451  6.58131   -1.90242  0.414 21.47836 ? 274  SER A CB   1 
ATOM   1295 C CB   B SER A 1 94  ? -5.00584  6.53787   -1.69777  0.586 21.59083 ? 274  SER A CB   1 
ATOM   1296 O OG   A SER A 1 94  ? -5.40644  6.16767   -0.67362  0.414 24.02355 ? 274  SER A OG   1 
ATOM   1297 O OG   B SER A 1 94  ? -4.03310  5.52295   -1.54046  0.586 26.70994 ? 274  SER A OG   1 
ATOM   1298 H H    A SER A 1 94  ? -7.08585  7.63416   -2.20339  0.414 19.53102 ? 274  SER A H    1 
ATOM   1299 H H    B SER A 1 94  ? -7.09978  7.66188   -2.20436  0.586 19.45861 ? 274  SER A H    1 
ATOM   1300 H HA   A SER A 1 94  ? -5.33748  6.52661   -3.85534  0.414 20.39594 ? 274  SER A HA   1 
ATOM   1301 H HA   B SER A 1 94  ? -5.26837  6.53988   -3.71284  0.586 20.30995 ? 274  SER A HA   1 
ATOM   1302 H HB2  A SER A 1 94  ? -4.04948  6.08278   -2.07001  0.414 25.77403 ? 274  SER A HB2  1 
ATOM   1303 H HB2  B SER A 1 94  ? -4.55537  7.39474   -1.75895  0.586 25.90900 ? 274  SER A HB2  1 
ATOM   1304 H HB3  A SER A 1 94  ? -4.66933  7.53034   -1.85610  0.414 25.77403 ? 274  SER A HB3  1 
ATOM   1305 H HB3  B SER A 1 94  ? -5.59512  6.52711   -0.92736  0.586 25.90900 ? 274  SER A HB3  1 
ATOM   1306 H HG   A SER A 1 94  ? -6.14242  6.55018   -0.54089  0.414 28.82826 ? 274  SER A HG   1 
ATOM   1307 H HG   B SER A 1 94  ? -4.40756  4.78886   -1.37766  0.586 32.05192 ? 274  SER A HG   1 
ATOM   1308 N N    . SER A 1 95  ? -7.43194  4.51109   -2.58221  1.000 17.16829 ? 275  SER A N    1 
ATOM   1309 C CA   . SER A 1 95  ? -7.92715  3.13829   -2.70603  1.000 18.54050 ? 275  SER A CA   1 
ATOM   1310 C C    . SER A 1 95  ? -8.39801  2.84895   -4.12651  1.000 15.53396 ? 275  SER A C    1 
ATOM   1311 O O    . SER A 1 95  ? -8.15750  1.75008   -4.68235  1.000 16.84954 ? 275  SER A O    1 
ATOM   1312 C CB   . SER A 1 95  ? -9.08466  2.95396   -1.72311  1.000 16.58507 ? 275  SER A CB   1 
ATOM   1313 O OG   . SER A 1 95  ? -8.59873  3.16659   -0.40159  1.000 20.76090 ? 275  SER A OG   1 
ATOM   1314 H H    . SER A 1 95  ? -7.94289  5.03465   -2.13008  1.000 20.60195 ? 275  SER A H    1 
ATOM   1315 H HA   . SER A 1 95  ? -7.21713  2.51241   -2.49379  1.000 22.24859 ? 275  SER A HA   1 
ATOM   1316 H HB2  . SER A 1 95  ? -9.78278  3.59810   -1.91959  1.000 19.90208 ? 275  SER A HB2  1 
ATOM   1317 H HB3  . SER A 1 95  ? -9.43424  2.05233   -1.79904  1.000 19.90208 ? 275  SER A HB3  1 
ATOM   1318 H HG   . SER A 1 95  ? -8.26170  3.93349   -0.33934  1.000 24.91308 ? 275  SER A HG   1 
ATOM   1319 N N    . MET A 1 96  ? -9.06734  3.83135   -4.73072  1.000 14.49109 ? 276  MET A N    1 
ATOM   1320 C CA   . MET A 1 96  ? -9.49610  3.69618   -6.12429  1.000 14.53779 ? 276  MET A CA   1 
ATOM   1321 C C    . MET A 1 96  ? -8.25981  3.55022   -7.00576  1.000 14.24390 ? 276  MET A C    1 
ATOM   1322 O O    . MET A 1 96  ? -8.18803  2.66558   -7.86324  1.000 14.54671 ? 276  MET A O    1 
ATOM   1323 C CB   . MET A 1 96  ? -10.30963 4.90573   -6.61133  1.000 17.73110 ? 276  MET A CB   1 
ATOM   1324 C CG   . MET A 1 96  ? -11.58996 5.27009   -5.88656  1.000 13.93672 ? 276  MET A CG   1 
ATOM   1325 S SD   . MET A 1 96  ? -12.16837 6.87457   -6.47418  1.000 18.07944 ? 276  MET A SD   1 
ATOM   1326 C CE   . MET A 1 96  ? -13.97789 6.82151   -6.14491  1.000 18.72598 ? 276  MET A CE   1 
ATOM   1327 H H    . MET A 1 96  ? -9.28378  4.57751   -4.36196  1.000 17.38931 ? 276  MET A H    1 
ATOM   1328 H HA   . MET A 1 96  ? -10.08352 2.92623   -6.17922  1.000 17.44535 ? 276  MET A HA   1 
ATOM   1329 H HB2  . MET A 1 96  ? -9.73395  5.68458   -6.55772  1.000 21.27732 ? 276  MET A HB2  1 
ATOM   1330 H HB3  . MET A 1 96  ? -10.55615 4.73830   -7.53442  1.000 21.27732 ? 276  MET A HB3  1 
ATOM   1331 H HG2  . MET A 1 96  ? -12.27182 4.60419   -6.06699  1.000 16.72407 ? 276  MET A HG2  1 
ATOM   1332 H HG3  . MET A 1 96  ? -11.42435 5.32523   -4.93239  1.000 16.72407 ? 276  MET A HG3  1 
ATOM   1333 H HE1  . MET A 1 96  ? -14.37798 7.65266   -6.44495  1.000 22.47117 ? 276  MET A HE1  1 
ATOM   1334 H HE2  . MET A 1 96  ? -14.36502 6.07474   -6.62798  1.000 22.47117 ? 276  MET A HE2  1 
ATOM   1335 H HE3  . MET A 1 96  ? -14.12239 6.70982   -5.19226  1.000 22.47117 ? 276  MET A HE3  1 
ATOM   1336 N N    . ASP A 1 97  ? -7.25566  4.40937   -6.78131  1.000 15.11396 ? 277  ASP A N    1 
ATOM   1337 C CA   . ASP A 1 97  ? -6.03289  4.38309   -7.57841  1.000 14.04875 ? 277  ASP A CA   1 
ATOM   1338 C C    . ASP A 1 97  ? -5.33267  3.03664   -7.44310  1.000 15.72377 ? 277  ASP A C    1 
ATOM   1339 O O    . ASP A 1 97  ? -4.77496  2.50346   -8.42190  1.000 15.99053 ? 277  ASP A O    1 
ATOM   1340 C CB   . ASP A 1 97  ? -5.08236  5.49742   -7.10749  1.000 16.95323 ? 277  ASP A CB   1 
ATOM   1341 C CG   . ASP A 1 97  ? -5.56107  6.89900   -7.42950  1.000 15.85766 ? 277  ASP A CG   1 
ATOM   1342 O OD1  . ASP A 1 97  ? -6.48947  7.06130   -8.22665  1.000 16.24939 ? 277  ASP A OD1  1 
ATOM   1343 O OD2  . ASP A 1 97  ? -4.94188  7.83535   -6.86552  1.000 17.43549 ? 277  ASP A OD2  1 
ATOM   1344 H H    . ASP A 1 97  ? -7.26126  5.01629   -6.17204  1.000 18.13675 ? 277  ASP A H    1 
ATOM   1345 H HA   . ASP A 1 97  ? -6.26006  4.53345   -8.50937  1.000 16.85850 ? 277  ASP A HA   1 
ATOM   1346 H HB2  . ASP A 1 97  ? -4.98316  5.43473   -6.14461  1.000 20.34388 ? 277  ASP A HB2  1 
ATOM   1347 H HB3  . ASP A 1 97  ? -4.22203  5.37448   -7.53834  1.000 20.34388 ? 277  ASP A HB3  1 
ATOM   1348 N N    . ASP A 1 98  ? -5.30007  2.48376   -6.23198  1.000 16.88489 ? 278  ASP A N    1 
ATOM   1349 C CA   . ASP A 1 98  ? -4.66033  1.18415   -5.99499  1.000 16.25398 ? 278  ASP A CA   1 
ATOM   1350 C C    . ASP A 1 98  ? -5.32956  0.09908   -6.84394  1.000 16.26536 ? 278  ASP A C    1 
ATOM   1351 O O    . ASP A 1 98  ? -4.65905  -0.72651  -7.48957  1.000 16.77520 ? 278  ASP A O    1 
ATOM   1352 C CB   . ASP A 1 98  ? -4.76598  0.85982   -4.49372  1.000 18.17253 ? 278  ASP A CB   1 
ATOM   1353 C CG   . ASP A 1 98  ? -3.84333  -0.23421  -4.00369  1.000 29.65472 ? 278  ASP A CG   1 
ATOM   1354 O OD1  . ASP A 1 98  ? -2.80158  -0.55080  -4.61170  1.000 26.16913 ? 278  ASP A OD1  1 
ATOM   1355 O OD2  . ASP A 1 98  ? -4.14239  -0.76111  -2.89957  1.000 29.96240 ? 278  ASP A OD2  1 
ATOM   1356 H H    . ASP A 1 98  ? -5.64067  2.83803   -5.52623  1.000 20.26187 ? 278  ASP A H    1 
ATOM   1357 H HA   . ASP A 1 98  ? -3.72257  1.21469   -6.24111  1.000 19.50477 ? 278  ASP A HA   1 
ATOM   1358 H HB2  . ASP A 1 98  ? -4.55558  1.66238   -3.99121  1.000 21.80703 ? 278  ASP A HB2  1 
ATOM   1359 H HB3  . ASP A 1 98  ? -5.67470  0.57839   -4.30416  1.000 21.80703 ? 278  ASP A HB3  1 
ATOM   1360 N N    . LEU A 1 99  ? -6.65711  0.10019   -6.88354  1.000 16.76732 ? 279  LEU A N    1 
ATOM   1361 C CA   . LEU A 1 99  ? -7.33132  -0.87377  -7.74153  1.000 17.49612 ? 279  LEU A CA   1 
ATOM   1362 C C    . LEU A 1 99  ? -6.95370  -0.69327  -9.21261  1.000 16.30449 ? 279  LEU A C    1 
ATOM   1363 O O    . LEU A 1 99  ? -6.62564  -1.64862  -9.91798  1.000 18.09283 ? 279  LEU A O    1 
ATOM   1364 C CB   . LEU A 1 99  ? -8.85034  -0.72870  -7.55914  1.000 17.35174 ? 279  LEU A CB   1 
ATOM   1365 C CG   . LEU A 1 99  ? -9.35074  -1.21504  -6.20223  1.000 17.15392 ? 279  LEU A CG   1 
ATOM   1366 C CD1  . LEU A 1 99  ? -10.79916 -0.82385  -6.09259  1.000 17.93063 ? 279  LEU A CD1  1 
ATOM   1367 C CD2  . LEU A 1 99  ? -9.20398  -2.70903  -6.07708  1.000 19.52622 ? 279  LEU A CD2  1 
ATOM   1368 H H    . LEU A 1 99  ? -7.17175  0.63035   -6.44345  1.000 20.12079 ? 279  LEU A H    1 
ATOM   1369 H HA   . LEU A 1 99  ? -7.05873  -1.76692  -7.47907  1.000 20.99534 ? 279  LEU A HA   1 
ATOM   1370 H HB2  . LEU A 1 99  ? -9.08681  0.20808   -7.64528  1.000 20.82209 ? 279  LEU A HB2  1 
ATOM   1371 H HB3  . LEU A 1 99  ? -9.29793  -1.24830  -8.24512  1.000 20.82209 ? 279  LEU A HB3  1 
ATOM   1372 H HG   . LEU A 1 99  ? -8.83377  -0.81845  -5.48365  1.000 20.58470 ? 279  LEU A HG   1 
ATOM   1373 H HD11 . LEU A 1 99  ? -11.15272 -1.15413  -5.25187  1.000 21.51675 ? 279  LEU A HD11 1 
ATOM   1374 H HD12 . LEU A 1 99  ? -10.86830 0.14320   -6.12339  1.000 21.51675 ? 279  LEU A HD12 1 
ATOM   1375 H HD13 . LEU A 1 99  ? -11.28867 -1.21423  -6.83346  1.000 21.51675 ? 279  LEU A HD13 1 
ATOM   1376 H HD21 . LEU A 1 99  ? -9.60897  -2.99747  -5.24420  1.000 23.43146 ? 279  LEU A HD21 1 
ATOM   1377 H HD22 . LEU A 1 99  ? -9.64994  -3.13402  -6.82635  1.000 23.43146 ? 279  LEU A HD22 1 
ATOM   1378 H HD23 . LEU A 1 99  ? -8.26073  -2.93520  -6.08199  1.000 23.43146 ? 279  LEU A HD23 1 
ATOM   1379 N N    . ILE A 1 100 ? -6.98412  0.55575   -9.68481  1.000 16.34375 ? 280  ILE A N    1 
ATOM   1380 C CA   . ILE A 1 100 ? -6.67012  0.79456   -11.08933 1.000 16.09328 ? 280  ILE A CA   1 
ATOM   1381 C C    . ILE A 1 100 ? -5.23397  0.38114   -11.40821 1.000 14.43127 ? 280  ILE A C    1 
ATOM   1382 O O    . ILE A 1 100 ? -4.96677  -0.21825  -12.45115 1.000 17.30769 ? 280  ILE A O    1 
ATOM   1383 C CB   . ILE A 1 100 ? -6.93064  2.27490   -11.44499 1.000 17.22560 ? 280  ILE A CB   1 
ATOM   1384 C CG1  . ILE A 1 100 ? -8.45139  2.54020   -11.46889 1.000 16.16967 ? 280  ILE A CG1  1 
ATOM   1385 C CG2  . ILE A 1 100 ? -6.28216  2.63589   -12.77115 1.000 17.08719 ? 280  ILE A CG2  1 
ATOM   1386 C CD1  . ILE A 1 100 ? -9.21254  1.75862   -12.57595 1.000 20.42244 ? 280  ILE A CD1  1 
ATOM   1387 H H    . ILE A 1 100 ? -7.17732  1.25718   -9.22627  1.000 19.61250 ? 280  ILE A H    1 
ATOM   1388 H HA   . ILE A 1 100 ? -7.25640  0.24324   -11.63084 1.000 19.31194 ? 280  ILE A HA   1 
ATOM   1389 H HB   . ILE A 1 100 ? -6.52904  2.83825   -10.76509 1.000 20.67072 ? 280  ILE A HB   1 
ATOM   1390 H HG12 . ILE A 1 100 ? -8.82597  2.27927   -10.61303 1.000 19.40361 ? 280  ILE A HG12 1 
ATOM   1391 H HG13 . ILE A 1 100 ? -8.59950  3.48666   -11.62116 1.000 19.40361 ? 280  ILE A HG13 1 
ATOM   1392 H HG21 . ILE A 1 100 ? -6.69400  3.44427   -13.11438 1.000 20.50463 ? 280  ILE A HG21 1 
ATOM   1393 H HG22 . ILE A 1 100 ? -5.33380  2.78231   -12.62945 1.000 20.50463 ? 280  ILE A HG22 1 
ATOM   1394 H HG23 . ILE A 1 100 ? -6.41441  1.90615   -13.39636 1.000 20.50463 ? 280  ILE A HG23 1 
ATOM   1395 H HD11 . ILE A 1 100 ? -10.11148 2.11488   -12.65279 1.000 24.50693 ? 280  ILE A HD11 1 
ATOM   1396 H HD12 . ILE A 1 100 ? -8.74184  1.86420   -13.41749 1.000 24.50693 ? 280  ILE A HD12 1 
ATOM   1397 H HD13 . ILE A 1 100 ? -9.24827  0.82038   -12.33237 1.000 24.50693 ? 280  ILE A HD13 1 
ATOM   1398 N N    A ARG A 1 101 ? -4.28658  0.65945   -10.51222 0.618 16.42266 ? 281  ARG A N    1 
ATOM   1399 N N    B ARG A 1 101 ? -4.28893  0.64920   -10.50566 0.382 16.45940 ? 281  ARG A N    1 
ATOM   1400 C CA   A ARG A 1 101 ? -2.90316  0.27520   -10.77519 0.618 16.86125 ? 281  ARG A CA   1 
ATOM   1401 C CA   B ARG A 1 101 ? -2.90030  0.27837   -10.77083 0.382 16.92281 ? 281  ARG A CA   1 
ATOM   1402 C C    A ARG A 1 101 ? -2.75311  -1.23403  -10.89183 0.618 18.87155 ? 281  ARG A C    1 
ATOM   1403 C C    B ARG A 1 101 ? -2.72375  -1.23205  -10.85544 0.382 18.91332 ? 281  ARG A C    1 
ATOM   1404 O O    A ARG A 1 101 ? -1.91737  -1.71860  -11.65689 0.618 20.95969 ? 281  ARG A O    1 
ATOM   1405 O O    B ARG A 1 101 ? -1.82525  -1.71228  -11.55406 0.382 20.84730 ? 281  ARG A O    1 
ATOM   1406 C CB   A ARG A 1 101 ? -1.97184  0.77992   -9.68960  0.618 17.66377 ? 281  ARG A CB   1 
ATOM   1407 C CB   B ARG A 1 101 ? -1.96929  0.84278   -9.70472  0.382 17.73742 ? 281  ARG A CB   1 
ATOM   1408 C CG   A ARG A 1 101 ? -1.67643  2.27158   -9.75580  0.618 18.14269 ? 281  ARG A CG   1 
ATOM   1409 C CG   B ARG A 1 101 ? -1.59068  2.30797   -9.93245  0.382 18.34846 ? 281  ARG A CG   1 
ATOM   1410 C CD   A ARG A 1 101 ? -0.45896  2.54918   -8.89825  0.618 20.49689 ? 281  ARG A CD   1 
ATOM   1411 C CD   B ARG A 1 101 ? -0.48681  2.74414   -8.97164  0.382 20.15777 ? 281  ARG A CD   1 
ATOM   1412 N NE   A ARG A 1 101 ? -0.39746  3.96541   -8.58293  0.618 21.99142 ? 281  ARG A NE   1 
ATOM   1413 N NE   B ARG A 1 101 ? -1.00058  2.87777   -7.61309  0.382 15.68299 ? 281  ARG A NE   1 
ATOM   1414 C CZ   A ARG A 1 101 ? -1.04049  4.53712   -7.57144  0.618 17.97456 ? 281  ARG A CZ   1 
ATOM   1415 C CZ   B ARG A 1 101 ? -1.44243  4.02047   -7.10292  0.382 19.98875 ? 281  ARG A CZ   1 
ATOM   1416 N NH1  A ARG A 1 101 ? -1.74950  3.82116   -6.71393  0.618 18.61936 ? 281  ARG A NH1  1 
ATOM   1417 N NH1  B ARG A 1 101 ? -1.37056  5.15709   -7.77938  0.382 21.26781 ? 281  ARG A NH1  1 
ATOM   1418 N NH2  A ARG A 1 101 ? -0.97589  5.85563   -7.42409  0.618 18.16460 ? 281  ARG A NH2  1 
ATOM   1419 N NH2  B ARG A 1 101 ? -1.97573  4.02492   -5.89017  0.382 18.68642 ? 281  ARG A NH2  1 
ATOM   1420 H H    A ARG A 1 101 ? -4.41596  1.06028   -9.76243  0.618 19.70720 ? 281  ARG A H    1 
ATOM   1421 H H    B ARG A 1 101 ? -4.42240  1.03608   -9.74927  0.382 19.75128 ? 281  ARG A H    1 
ATOM   1422 H HA   A ARG A 1 101 ? -2.64244  0.69059   -11.61208 0.618 20.23350 ? 281  ARG A HA   1 
ATOM   1423 H HA   B ARG A 1 101 ? -2.64901  0.66887   -11.62246 0.382 20.30738 ? 281  ARG A HA   1 
ATOM   1424 H HB2  A ARG A 1 101 ? -2.37644  0.59926   -8.82672  0.618 21.19653 ? 281  ARG A HB2  1 
ATOM   1425 H HB2  B ARG A 1 101 ? -2.40863  0.78073   -8.84215  0.382 21.28490 ? 281  ARG A HB2  1 
ATOM   1426 H HB3  A ARG A 1 101 ? -1.12653  0.31010   -9.76456  0.618 21.19653 ? 281  ARG A HB3  1 
ATOM   1427 H HB3  B ARG A 1 101 ? -1.15059  0.32259   -9.69823  0.382 21.28490 ? 281  ARG A HB3  1 
ATOM   1428 H HG2  A ARG A 1 101 ? -1.48906  2.53478   -10.67042 0.618 21.77122 ? 281  ARG A HG2  1 
ATOM   1429 H HG2  B ARG A 1 101 ? -1.26947  2.42132   -10.84067 0.382 22.01815 ? 281  ARG A HG2  1 
ATOM   1430 H HG3  A ARG A 1 101 ? -2.43004  2.77694   -9.41291  0.618 21.77122 ? 281  ARG A HG3  1 
ATOM   1431 H HG3  B ARG A 1 101 ? -2.36736  2.86944   -9.78274  0.382 22.01815 ? 281  ARG A HG3  1 
ATOM   1432 H HD2  A ARG A 1 101 ? -0.51881  2.04663   -8.07075  0.618 24.59627 ? 281  ARG A HD2  1 
ATOM   1433 H HD2  B ARG A 1 101 ? 0.22029   2.08013   -8.96893  0.382 24.18933 ? 281  ARG A HD2  1 
ATOM   1434 H HD3  A ARG A 1 101 ? 0.34545   2.30058   -9.37993  0.618 24.59627 ? 281  ARG A HD3  1 
ATOM   1435 H HD3  B ARG A 1 101 ? -0.13434  3.60298   -9.25282  0.382 24.18933 ? 281  ARG A HD3  1 
ATOM   1436 H HE   A ARG A 1 101 ? 0.08790   4.46747   -9.08487  0.618 26.38970 ? 281  ARG A HE   1 
ATOM   1437 H HE   B ARG A 1 101 ? -1.01817  2.17699   -7.11489  0.382 18.81959 ? 281  ARG A HE   1 
ATOM   1438 H HH11 A ARG A 1 101 ? -1.80073  2.96758   -6.80549  0.618 22.34324 ? 281  ARG A HH11 1 
ATOM   1439 H HH11 B ARG A 1 101 ? -1.03110  5.16652   -8.56949  0.382 25.52137 ? 281  ARG A HH11 1 
ATOM   1440 H HH12 A ARG A 1 101 ? -2.15911  4.20938   -6.06500  0.618 22.34324 ? 281  ARG A HH12 1 
ATOM   1441 H HH12 B ARG A 1 101 ? -1.66335  5.88559   -7.42844  0.382 25.52137 ? 281  ARG A HH12 1 
ATOM   1442 H HH21 A ARG A 1 101 ? -0.52144  6.32870   -7.98021  0.618 21.79752 ? 281  ARG A HH21 1 
ATOM   1443 H HH21 B ARG A 1 101 ? -2.03256  3.29268   -5.44274  0.382 22.42370 ? 281  ARG A HH21 1 
ATOM   1444 H HH22 A ARG A 1 101 ? -1.38850  6.23622   -6.77255  0.618 21.79752 ? 281  ARG A HH22 1 
ATOM   1445 H HH22 B ARG A 1 101 ? -2.26508  4.76004   -5.55037  0.382 22.42370 ? 281  ARG A HH22 1 
ATOM   1446 N N    . HIS A 1 102 ? -3.53390  -1.99131  -10.11493 1.000 18.58670 ? 282  HIS A N    1 
ATOM   1447 C CA   . HIS A 1 102 ? -3.48868  -3.43903  -10.22705 1.000 20.92691 ? 282  HIS A CA   1 
ATOM   1448 C C    . HIS A 1 102 ? -4.17494  -3.96783  -11.47447 1.000 18.74018 ? 282  HIS A C    1 
ATOM   1449 O O    . HIS A 1 102 ? -4.04752  -5.15509  -11.79766 1.000 19.61716 ? 282  HIS A O    1 
ATOM   1450 C CB   . HIS A 1 102 ? -4.13889  -4.03828  -8.98028  1.000 18.68976 ? 282  HIS A CB   1 
ATOM   1451 C CG   . HIS A 1 102 ? -3.25633  -4.02774  -7.77409  1.000 20.01971 ? 282  HIS A CG   1 
ATOM   1452 N ND1  . HIS A 1 102 ? -3.05064  -2.90509  -6.99766  1.000 20.22785 ? 282  HIS A ND1  1 
ATOM   1453 C CD2  . HIS A 1 102 ? -2.52352  -5.01229  -7.21285  1.000 21.99606 ? 282  HIS A CD2  1 
ATOM   1454 C CE1  . HIS A 1 102 ? -2.24253  -3.21701  -5.99602  1.000 20.77393 ? 282  HIS A CE1  1 
ATOM   1455 N NE2  . HIS A 1 102 ? -1.89474  -4.48594  -6.10599  1.000 21.94998 ? 282  HIS A NE2  1 
ATOM   1456 H H    . HIS A 1 102 ? -4.08598  -1.69081  -9.52797  1.000 22.30404 ? 282  HIS A H    1 
ATOM   1457 H HA   . HIS A 1 102 ? -2.56467  -3.72974  -10.27799 1.000 25.11230 ? 282  HIS A HA   1 
ATOM   1458 H HB2  . HIS A 1 102 ? -4.93557  -3.52718  -8.76818  1.000 22.42772 ? 282  HIS A HB2  1 
ATOM   1459 H HB3  . HIS A 1 102 ? -4.37585  -4.96053  -9.16521  1.000 22.42772 ? 282  HIS A HB3  1 
ATOM   1460 H HD1  . HIS A 1 102 ? -3.39198  -2.12889  -7.14118  1.000 24.27342 ? 282  HIS A HD1  1 
ATOM   1461 H HD2  . HIS A 1 102 ? -2.45535  -5.88806  -7.51825  1.000 26.39527 ? 282  HIS A HD2  1 
ATOM   1462 H HE1  . HIS A 1 102 ? -1.96511  -2.63666  -5.32436  1.000 24.92871 ? 282  HIS A HE1  1 
ATOM   1463 N N    . CYS A 1 103 ? -4.95058  -3.11264  -12.14792 1.000 21.34303 ? 283  CYS A N    1 
ATOM   1464 C CA   . CYS A 1 103 ? -5.53243  -3.44128  -13.45851 1.000 25.44595 ? 283  CYS A CA   1 
ATOM   1465 C C    . CYS A 1 103 ? -4.67083  -3.04855  -14.66588 1.000 23.97844 ? 283  CYS A C    1 
ATOM   1466 O O    . CYS A 1 103 ? -5.16666  -3.13000  -15.80126 1.000 26.96596 ? 283  CYS A O    1 
ATOM   1467 C CB   . CYS A 1 103 ? -6.88621  -2.76685  -13.61889 1.000 24.61095 ? 283  CYS A CB   1 
ATOM   1468 S SG   . CYS A 1 103 ? -8.10514  -3.23487  -12.46427 1.000 26.13255 ? 283  CYS A SG   1 
ATOM   1469 H H    . CYS A 1 103 ? -5.15763  -2.32727  -11.86519 1.000 25.61163 ? 283  CYS A H    1 
ATOM   1470 H HA   . CYS A 1 103 ? -5.63699  -4.40555  -13.47067 1.000 30.53514 ? 283  CYS A HA   1 
ATOM   1471 H HB2  . CYS A 1 103 ? -6.76086  -1.80884  -13.53290 1.000 29.53314 ? 283  CYS A HB2  1 
ATOM   1472 H HB3  . CYS A 1 103 ? -7.22894  -2.97871  -14.50125 1.000 29.53314 ? 283  CYS A HB3  1 
ATOM   1473 H HG   . CYS A 1 103 ? -7.68331  -3.05338  -11.35561 1.000 31.35906 ? 283  CYS A HG   1 
ATOM   1474 N N    . ASN A 1 104 ? -3.41630  -2.63337  -14.48133 1.000 31.59263 ? 284  ASN A N    1 
ATOM   1475 C CA   . ASN A 1 104 ? -2.66110  -2.07308  -15.59487 1.000 26.86849 ? 284  ASN A CA   1 
ATOM   1476 C C    . ASN A 1 104 ? -2.61551  -3.01706  -16.77801 1.000 27.94835 ? 284  ASN A C    1 
ATOM   1477 O O    . ASN A 1 104 ? -2.21389  -4.18595  -16.66680 1.000 28.04656 ? 284  ASN A O    1 
ATOM   1478 C CB   . ASN A 1 104 ? -1.24163  -1.72087  -15.14377 1.000 25.44904 ? 284  ASN A CB   1 
ATOM   1479 H H    . ASN A 1 104 ? -2.99085  -2.66594  -13.73465 1.000 37.91115 ? 284  ASN A H    1 
ATOM   1480 H HA   . ASN A 1 104 ? -3.10508  -1.25974  -15.88166 1.000 32.24219 ? 284  ASN A HA   1 
ATOM   1481 N N    . GLY A 1 105 ? -3.02693  -2.51103  -17.93826 1.000 26.56551 ? 285  GLY A N    1 
ATOM   1482 C CA   . GLY A 1 105 ? -2.96816  -3.28222  -19.13991 1.000 22.97322 ? 285  GLY A CA   1 
ATOM   1483 C C    . GLY A 1 105 ? -4.01101  -4.36934  -19.27227 1.000 25.44132 ? 285  GLY A C    1 
ATOM   1484 O O    . GLY A 1 105 ? -3.92560  -5.17018  -20.20534 1.000 26.13096 ? 285  GLY A O    1 
ATOM   1485 H H    . GLY A 1 105 ? -3.34335  -1.71788  -18.04023 1.000 31.87861 ? 285  GLY A H    1 
ATOM   1486 H HA2  . GLY A 1 105 ? -3.07327  -2.68277  -19.89524 1.000 27.56786 ? 285  GLY A HA2  1 
ATOM   1487 H HA3  . GLY A 1 105 ? -2.09677  -3.70521  -19.19131 1.000 27.56786 ? 285  GLY A HA3  1 
ATOM   1488 N N    . LYS A 1 106 ? -4.98105  -4.43833  -18.37462 1.000 19.81202 ? 286  LYS A N    1 
ATOM   1489 C CA   . LYS A 1 106 ? -5.98855  -5.48042  -18.47914 1.000 18.12519 ? 286  LYS A CA   1 
ATOM   1490 C C    . LYS A 1 106 ? -7.37511  -4.93525  -18.69941 1.000 16.49525 ? 286  LYS A C    1 
ATOM   1491 O O    . LYS A 1 106 ? -8.29913  -5.73723  -18.90566 1.000 20.68418 ? 286  LYS A O    1 
ATOM   1492 C CB   . LYS A 1 106 ? -6.00337  -6.35509  -17.22387 1.000 21.65238 ? 286  LYS A CB   1 
ATOM   1493 C CG   . LYS A 1 106 ? -4.65854  -7.02320  -16.91928 1.000 27.55535 ? 286  LYS A CG   1 
ATOM   1494 C CD   . LYS A 1 106 ? -4.77770  -8.52795  -16.62117 1.000 34.01624 ? 286  LYS A CD   1 
ATOM   1495 C CE   . LYS A 1 106 ? -3.40835  -9.23303  -16.72092 1.000 44.45858 ? 286  LYS A CE   1 
ATOM   1496 N NZ   . LYS A 1 106 ? -3.16485  -10.29822 -15.69222 1.000 35.75173 ? 286  LYS A NZ   1 
ATOM   1497 H H    . LYS A 1 106 ? -5.07545  -3.90303  -17.70818 1.000 23.77442 ? 286  LYS A H    1 
ATOM   1498 H HA   . LYS A 1 106 ? -5.75433  -6.04591  -19.23165 1.000 21.75023 ? 286  LYS A HA   1 
ATOM   1499 H HB2  . LYS A 1 106 ? -6.23860  -5.80270  -16.46201 1.000 25.98285 ? 286  LYS A HB2  1 
ATOM   1500 H HB3  . LYS A 1 106 ? -6.66263  -7.05692  -17.34095 1.000 25.98285 ? 286  LYS A HB3  1 
ATOM   1501 H HG2  . LYS A 1 106 ? -4.07462  -6.91796  -17.68665 1.000 33.06641 ? 286  LYS A HG2  1 
ATOM   1502 H HG3  . LYS A 1 106 ? -4.26496  -6.59686  -16.14196 1.000 33.06641 ? 286  LYS A HG3  1 
ATOM   1503 H HD2  . LYS A 1 106 ? -5.11968  -8.65148  -15.72190 1.000 40.81949 ? 286  LYS A HD2  1 
ATOM   1504 H HD3  . LYS A 1 106 ? -5.37872  -8.93642  -17.26369 1.000 40.81949 ? 286  LYS A HD3  1 
ATOM   1505 H HE2  . LYS A 1 106 ? -3.34114  -9.65188  -17.59325 1.000 53.35030 ? 286  LYS A HE2  1 
ATOM   1506 H HE3  . LYS A 1 106 ? -2.71122  -8.56641  -16.61839 1.000 53.35030 ? 286  LYS A HE3  1 
ATOM   1507 H HZ1  . LYS A 1 106 ? -3.77906  -10.93814 -15.76539 1.000 42.90208 ? 286  LYS A HZ1  1 
ATOM   1508 H HZ2  . LYS A 1 106 ? -2.35881  -10.65668 -15.81012 1.000 42.90208 ? 286  LYS A HZ2  1 
ATOM   1509 H HZ3  . LYS A 1 106 ? -3.20852  -9.94801  -14.87519 1.000 42.90208 ? 286  LYS A HZ3  1 
ATOM   1510 N N    . LEU A 1 107 ? -7.56160  -3.61206  -18.69259 1.000 18.43628 ? 287  LEU A N    1 
ATOM   1511 C CA   . LEU A 1 107 ? -8.87322  -2.98621  -18.94522 1.000 16.55025 ? 287  LEU A CA   1 
ATOM   1512 C C    . LEU A 1 107 ? -8.90354  -2.60112  -20.41202 1.000 19.44774 ? 287  LEU A C    1 
ATOM   1513 O O    . LEU A 1 107 ? -8.36677  -1.56135  -20.80663 1.000 19.26455 ? 287  LEU A O    1 
ATOM   1514 C CB   . LEU A 1 107 ? -9.09639  -1.78519  -18.05209 1.000 18.35445 ? 287  LEU A CB   1 
ATOM   1515 C CG   . LEU A 1 107 ? -9.24006  -2.12522  -16.57435 1.000 18.10672 ? 287  LEU A CG   1 
ATOM   1516 C CD1  . LEU A 1 107 ? -9.27103  -0.83981  -15.75177 1.000 21.02819 ? 287  LEU A CD1  1 
ATOM   1517 C CD2  . LEU A 1 107 ? -10.52795 -2.93462  -16.35320 1.000 20.38595 ? 287  LEU A CD2  1 
ATOM   1518 H H    . LEU A 1 107 ? -6.93501  -3.04263  -18.54182 1.000 22.12354 ? 287  LEU A H    1 
ATOM   1519 H HA   . LEU A 1 107 ? -9.57983  -3.62482  -18.76143 1.000 19.86030 ? 287  LEU A HA   1 
ATOM   1520 H HB2  . LEU A 1 107 ? -8.33951  -1.18564  -18.14467 1.000 22.02534 ? 287  LEU A HB2  1 
ATOM   1521 H HB3  . LEU A 1 107 ? -9.91017  -1.33788  -18.33241 1.000 22.02534 ? 287  LEU A HB3  1 
ATOM   1522 H HG   . LEU A 1 107 ? -8.48603  -2.66001  -16.28051 1.000 21.72806 ? 287  LEU A HG   1 
ATOM   1523 H HD11 . LEU A 1 107 ? -9.38583  -1.06662  -14.81567 1.000 25.23383 ? 287  LEU A HD11 1 
ATOM   1524 H HD12 . LEU A 1 107 ? -8.43469  -0.36463  -15.87683 1.000 25.23383 ? 287  LEU A HD12 1 
ATOM   1525 H HD13 . LEU A 1 107 ? -10.01179 -0.29037  -16.05225 1.000 25.23383 ? 287  LEU A HD13 1 
ATOM   1526 H HD21 . LEU A 1 107 ? -10.68286 -3.02747  -15.40017 1.000 24.46314 ? 287  LEU A HD21 1 
ATOM   1527 H HD22 . LEU A 1 107 ? -11.27043 -2.46541  -16.76485 1.000 24.46314 ? 287  LEU A HD22 1 
ATOM   1528 H HD23 . LEU A 1 107 ? -10.42434 -3.80988  -16.75829 1.000 24.46314 ? 287  LEU A HD23 1 
ATOM   1529 N N    . GLY A 1 108 ? -9.52377  -3.43611  -21.22559 1.000 19.06026 ? 288  GLY A N    1 
ATOM   1530 C CA   . GLY A 1 108 ? -9.52757  -3.17174  -22.65666 1.000 23.66751 ? 288  GLY A CA   1 
ATOM   1531 C C    . GLY A 1 108 ? -8.11053  -3.02268  -23.17208 1.000 22.17660 ? 288  GLY A C    1 
ATOM   1532 O O    . GLY A 1 108 ? -7.18330  -3.67802  -22.71700 1.000 24.94571 ? 288  GLY A O    1 
ATOM   1533 H H    . GLY A 1 108 ? -9.94163  -4.14790  -20.98405 1.000 22.87231 ? 288  GLY A H    1 
ATOM   1534 H HA2  . GLY A 1 108 ? -9.95608  -3.90502  -23.12525 1.000 28.40102 ? 288  GLY A HA2  1 
ATOM   1535 H HA3  . GLY A 1 108 ? -10.01499 -2.35302  -22.83839 1.000 28.40102 ? 288  GLY A HA3  1 
ATOM   1536 N N    . SER A 1 109 ? -7.92894  -2.11222  -24.13172 1.000 22.54026 ? 289  SER A N    1 
ATOM   1537 C CA   . SER A 1 109 ? -6.60879  -1.81293  -24.67216 1.000 23.38337 ? 289  SER A CA   1 
ATOM   1538 C C    . SER A 1 109 ? -6.03597  -0.51602  -24.10693 1.000 21.83527 ? 289  SER A C    1 
ATOM   1539 O O    . SER A 1 109 ? -5.08979  0.04350   -24.67847 1.000 21.95538 ? 289  SER A O    1 
ATOM   1540 C CB   . SER A 1 109 ? -6.68022  -1.72714  -26.18641 1.000 28.29702 ? 289  SER A CB   1 
ATOM   1541 O OG   . SER A 1 109 ? -7.55285  -0.66686  -26.54157 1.000 41.63539 ? 289  SER A OG   1 
ATOM   1542 H H    . SER A 1 109 ? -8.56353  -1.65275  -24.48638 1.000 27.04831 ? 289  SER A H    1 
ATOM   1543 H HA   . SER A 1 109 ? -6.00622  -2.53507  -24.43483 1.000 28.06005 ? 289  SER A HA   1 
ATOM   1544 H HB2  . SER A 1 109 ? -5.79540  -1.55216  -26.54332 1.000 33.95642 ? 289  SER A HB2  1 
ATOM   1545 H HB3  . SER A 1 109 ? -7.02253  -2.56190  -26.54264 1.000 33.95642 ? 289  SER A HB3  1 
ATOM   1546 H HG   . SER A 1 109 ? -7.59154  -0.59440  -27.37755 1.000 49.96247 ? 289  SER A HG   1 
ATOM   1547 N N    . TYR A 1 110 ? -6.59196  -0.03409  -22.99747 1.000 19.46739 ? 290  TYR A N    1 
ATOM   1548 C CA   . TYR A 1 110 ? -6.19550  1.24408   -22.44343 1.000 19.57933 ? 290  TYR A CA   1 
ATOM   1549 C C    . TYR A 1 110 ? -4.88704  1.12576   -21.66441 1.000 19.81305 ? 290  TYR A C    1 
ATOM   1550 O O    . TYR A 1 110 ? -4.51111  0.05931   -21.16050 1.000 22.83603 ? 290  TYR A O    1 
ATOM   1551 C CB   . TYR A 1 110 ? -7.28591  1.75880   -21.52057 1.000 17.28057 ? 290  TYR A CB   1 
ATOM   1552 C CG   . TYR A 1 110 ? -8.64144  1.99414   -22.18371 1.000 19.06753 ? 290  TYR A CG   1 
ATOM   1553 C CD1  . TYR A 1 110 ? -8.75853  2.85134   -23.25947 1.000 18.87504 ? 290  TYR A CD1  1 
ATOM   1554 C CD2  . TYR A 1 110 ? -9.79007  1.41240   -21.67774 1.000 20.23720 ? 290  TYR A CD2  1 
ATOM   1555 C CE1  . TYR A 1 110 ? -10.00690 3.08530   -23.86680 1.000 19.11602 ? 290  TYR A CE1  1 
ATOM   1556 C CE2  . TYR A 1 110 ? -11.01288 1.65208   -22.24628 1.000 19.79044 ? 290  TYR A CE2  1 
ATOM   1557 C CZ   . TYR A 1 110 ? -11.12396 2.48843   -23.32228 1.000 21.75834 ? 290  TYR A CZ   1 
ATOM   1558 O OH   . TYR A 1 110 ? -12.35512 2.72625   -23.89447 1.000 23.44196 ? 290  TYR A OH   1 
ATOM   1559 H H    . TYR A 1 110 ? -7.20519  -0.43567  -22.54773 1.000 23.36087 ? 290  TYR A H    1 
ATOM   1560 H HA   . TYR A 1 110 ? -6.05725  1.87969   -23.16300 1.000 23.49520 ? 290  TYR A HA   1 
ATOM   1561 H HB2  . TYR A 1 110 ? -7.41866  1.11011   -20.81170 1.000 20.73668 ? 290  TYR A HB2  1 
ATOM   1562 H HB3  . TYR A 1 110 ? -6.99569  2.60508   -21.14575 1.000 20.73668 ? 290  TYR A HB3  1 
ATOM   1563 H HD1  . TYR A 1 110 ? -8.00165  3.28057   -23.58780 1.000 22.65005 ? 290  TYR A HD1  1 
ATOM   1564 H HD2  . TYR A 1 110 ? -9.73101  0.84957   -20.93974 1.000 24.28464 ? 290  TYR A HD2  1 
ATOM   1565 H HE1  . TYR A 1 110 ? -10.07637 3.62966   -24.61763 1.000 22.93922 ? 290  TYR A HE1  1 
ATOM   1566 H HE2  . TYR A 1 110 ? -11.77236 1.24342   -21.89830 1.000 23.74853 ? 290  TYR A HE2  1 
ATOM   1567 H HH   . TYR A 1 110 ? -12.26692 3.21087   -24.57488 1.000 28.13035 ? 290  TYR A HH   1 
ATOM   1568 N N    . LYS A 1 111 ? -4.16558  2.23548   -21.60306 1.000 20.15079 ? 291  LYS A N    1 
ATOM   1569 C CA   . LYS A 1 111 ? -2.95711  2.37258   -20.78511 1.000 19.52640 ? 291  LYS A CA   1 
ATOM   1570 C C    . LYS A 1 111 ? -3.26414  3.51630   -19.82073 1.000 19.25721 ? 291  LYS A C    1 
ATOM   1571 O O    . LYS A 1 111 ? -3.17401  4.68021   -20.19297 1.000 21.60786 ? 291  LYS A O    1 
ATOM   1572 C CB   . LYS A 1 111 ? -1.75429  2.70812   -21.65255 1.000 25.63644 ? 291  LYS A CB   1 
ATOM   1573 C CG   . LYS A 1 111 ? -0.40972  2.33996   -21.03850 1.000 36.46472 ? 291  LYS A CG   1 
ATOM   1574 C CD   . LYS A 1 111 ? 0.66384   2.19335   -22.12372 1.000 45.88065 ? 291  LYS A CD   1 
ATOM   1575 C CE   . LYS A 1 111 ? 0.99128   3.48706   -22.86610 1.000 48.70569 ? 291  LYS A CE   1 
ATOM   1576 N NZ   . LYS A 1 111 ? 1.38357   4.63039   -21.99012 1.000 56.80489 ? 291  LYS A NZ   1 
ATOM   1577 H H    . LYS A 1 111 ? -4.35875  2.95060   -22.03996 1.000 24.18095 ? 291  LYS A H    1 
ATOM   1578 H HA   . LYS A 1 111 ? -2.76253  1.55397   -20.30249 1.000 23.43168 ? 291  LYS A HA   1 
ATOM   1579 H HB2  . LYS A 1 111 ? -1.83468  2.22753   -22.49128 1.000 30.76373 ? 291  LYS A HB2  1 
ATOM   1580 H HB3  . LYS A 1 111 ? -1.74923  3.66405   -21.81711 1.000 30.76373 ? 291  LYS A HB3  1 
ATOM   1581 H HG2  . LYS A 1 111 ? -0.13260  3.03733   -20.42386 1.000 43.75767 ? 291  LYS A HG2  1 
ATOM   1582 H HG3  . LYS A 1 111 ? -0.48895  1.49538   -20.56807 1.000 43.75767 ? 291  LYS A HG3  1 
ATOM   1583 H HD2  . LYS A 1 111 ? 1.48255   1.87853   -21.70958 1.000 55.05678 ? 291  LYS A HD2  1 
ATOM   1584 H HD3  . LYS A 1 111 ? 0.35528   1.54943   -22.78027 1.000 55.05678 ? 291  LYS A HD3  1 
ATOM   1585 H HE2  . LYS A 1 111 ? 1.73045   3.31695   -23.47074 1.000 58.44683 ? 291  LYS A HE2  1 
ATOM   1586 H HE3  . LYS A 1 111 ? 0.20801   3.76097   -23.36847 1.000 58.44683 ? 291  LYS A HE3  1 
ATOM   1587 H HZ1  . LYS A 1 111 ? 0.71728   4.83142   -21.43538 1.000 68.16587 ? 291  LYS A HZ1  1 
ATOM   1588 H HZ2  . LYS A 1 111 ? 2.10250   4.41473   -21.51186 1.000 68.16587 ? 291  LYS A HZ2  1 
ATOM   1589 H HZ3  . LYS A 1 111 ? 1.57092   5.34444   -22.48725 1.000 68.16587 ? 291  LYS A HZ3  1 
ATOM   1590 N N    . ILE A 1 112 ? -3.68194  3.20657   -18.60104 1.000 16.18843 ? 292  ILE A N    1 
ATOM   1591 C CA   . ILE A 1 112 ? -4.15219  4.21837   -17.66474 1.000 16.98186 ? 292  ILE A CA   1 
ATOM   1592 C C    . ILE A 1 112 ? -2.98163  4.74821   -16.83456 1.000 19.76948 ? 292  ILE A C    1 
ATOM   1593 O O    . ILE A 1 112 ? -2.36677  3.99170   -16.07768 1.000 26.39592 ? 292  ILE A O    1 
ATOM   1594 C CB   . ILE A 1 112 ? -5.24903  3.65754   -16.78109 1.000 16.80783 ? 292  ILE A CB   1 
ATOM   1595 C CG1  . ILE A 1 112 ? -6.42086  3.25511   -17.65537 1.000 20.92215 ? 292  ILE A CG1  1 
ATOM   1596 C CG2  . ILE A 1 112 ? -5.58077  4.72561   -15.69296 1.000 20.43503 ? 292  ILE A CG2  1 
ATOM   1597 C CD1  . ILE A 1 112 ? -7.51312  2.49709   -16.90689 1.000 24.73463 ? 292  ILE A CD1  1 
ATOM   1598 H H    . ILE A 1 112 ? -3.70304  2.40601   -18.28758 1.000 19.42611 ? 292  ILE A H    1 
ATOM   1599 H HA   . ILE A 1 112 ? -4.50210  4.97046   -18.16757 1.000 20.37823 ? 292  ILE A HA   1 
ATOM   1600 H HB   . ILE A 1 112 ? -4.97973  2.85242   -16.31187 1.000 20.16939 ? 292  ILE A HB   1 
ATOM   1601 H HG12 . ILE A 1 112 ? -6.81978  4.05578   -18.03045 1.000 25.10658 ? 292  ILE A HG12 1 
ATOM   1602 H HG13 . ILE A 1 112 ? -6.09661  2.68133   -18.36708 1.000 25.10658 ? 292  ILE A HG13 1 
ATOM   1603 H HG21 . ILE A 1 112 ? -6.40178  4.47295   -15.24240 1.000 24.52204 ? 292  ILE A HG21 1 
ATOM   1604 H HG22 . ILE A 1 112 ? -4.85131  4.76332   -15.05472 1.000 24.52204 ? 292  ILE A HG22 1 
ATOM   1605 H HG23 . ILE A 1 112 ? -5.69065  5.58904   -16.12111 1.000 24.52204 ? 292  ILE A HG23 1 
ATOM   1606 H HD11 . ILE A 1 112 ? -8.15620  2.15538   -17.54766 1.000 29.68156 ? 292  ILE A HD11 1 
ATOM   1607 H HD12 . ILE A 1 112 ? -7.10983  1.76213   -16.41895 1.000 29.68156 ? 292  ILE A HD12 1 
ATOM   1608 H HD13 . ILE A 1 112 ? -7.95158  3.10308   -16.28929 1.000 29.68156 ? 292  ILE A HD13 1 
ATOM   1609 N N    . ASN A 1 113 ? -2.68571  6.04506   -16.97592 1.000 20.28840 ? 293  ASN A N    1 
ATOM   1610 C CA   . ASN A 1 113 ? -1.53388  6.68216   -16.33524 1.000 22.58522 ? 293  ASN A CA   1 
ATOM   1611 C C    . ASN A 1 113 ? -1.91761  7.82001   -15.39721 1.000 18.71665 ? 293  ASN A C    1 
ATOM   1612 O O    . ASN A 1 113 ? -1.05517  8.36975   -14.73201 1.000 20.12855 ? 293  ASN A O    1 
ATOM   1613 C CB   . ASN A 1 113 ? -0.55407  7.25994   -17.39270 1.000 22.87791 ? 293  ASN A CB   1 
ATOM   1614 C CG   . ASN A 1 113 ? -1.15612  8.42155   -18.20567 1.000 39.50361 ? 293  ASN A CG   1 
ATOM   1615 O OD1  . ASN A 1 113 ? -2.38142  8.57511   -18.32488 1.000 35.89491 ? 293  ASN A OD1  1 
ATOM   1616 N ND2  . ASN A 1 113 ? -0.27468  9.23269   -18.80090 1.000 43.37735 ? 293  ASN A ND2  1 
ATOM   1617 H H    . ASN A 1 113 ? -3.15087  6.59023   -17.45132 1.000 24.34607 ? 293  ASN A H    1 
ATOM   1618 H HA   . ASN A 1 113 ? -1.06335  6.00062   -15.83026 1.000 27.10226 ? 293  ASN A HA   1 
ATOM   1619 H HB2  . ASN A 1 113 ? 0.23738   7.59133   -16.94027 1.000 27.45349 ? 293  ASN A HB2  1 
ATOM   1620 H HB3  . ASN A 1 113 ? -0.31074  6.55583   -18.01393 1.000 27.45349 ? 293  ASN A HB3  1 
ATOM   1621 H HD21 . ASN A 1 113 ? 0.56873   9.08776   -18.71572 1.000 52.05282 ? 293  ASN A HD21 1 
ATOM   1622 H HD22 . ASN A 1 113 ? -0.55138  9.89912   -19.26877 1.000 52.05282 ? 293  ASN A HD22 1 
ATOM   1623 N N    . GLY A 1 114 ? -3.17635  8.22997   -15.38606 1.000 16.21377 ? 294  GLY A N    1 
ATOM   1624 C CA   . GLY A 1 114 ? -3.51725  9.43274   -14.66063 1.000 16.89493 ? 294  GLY A CA   1 
ATOM   1625 C C    . GLY A 1 114 ? -5.01872  9.51520   -14.53247 1.000 14.27687 ? 294  GLY A C    1 
ATOM   1626 O O    . GLY A 1 114 ? -5.76835  8.65917   -15.02046 1.000 14.27805 ? 294  GLY A O    1 
ATOM   1627 H H    A GLY A 1 114 ? -3.83190  7.83776   -15.78106 0.500 19.45652 ? 294  GLY A H    1 
ATOM   1628 H H    B GLY A 1 114 ? -3.83190  7.83776   -15.78106 0.500 19.45652 ? 294  GLY A H    1 
ATOM   1629 H HA2  . GLY A 1 114 ? -3.12091  9.41417   -13.77549 1.000 20.27392 ? 294  GLY A HA2  1 
ATOM   1630 H HA3  . GLY A 1 114 ? -3.19307  10.21397  -15.13547 1.000 20.27392 ? 294  GLY A HA3  1 
ATOM   1631 N N    . ARG A 1 115 ? -5.45624  10.55383  -13.81792 1.000 14.52418 ? 295  ARG A N    1 
ATOM   1632 C CA   . ARG A 1 115 ? -6.88213  10.76225  -13.60287 1.000 13.32538 ? 295  ARG A CA   1 
ATOM   1633 C C    . ARG A 1 115 ? -7.14536  12.23770  -13.28621 1.000 13.60726 ? 295  ARG A C    1 
ATOM   1634 O O    . ARG A 1 115 ? -6.24350  13.03012  -13.01603 1.000 15.21765 ? 295  ARG A O    1 
ATOM   1635 C CB   . ARG A 1 115 ? -7.41638  9.88785   -12.47126 1.000 15.95339 ? 295  ARG A CB   1 
ATOM   1636 C CG   . ARG A 1 115 ? -6.73395  10.07799  -11.15276 1.000 17.73637 ? 295  ARG A CG   1 
ATOM   1637 C CD   . ARG A 1 115 ? -7.67314  9.81334   -9.98634  1.000 18.06117 ? 295  ARG A CD   1 
ATOM   1638 N NE   . ARG A 1 115 ? -6.99444  9.76890   -8.70582  1.000 19.75242 ? 295  ARG A NE   1 
ATOM   1639 C CZ   . ARG A 1 115 ? -6.53374  10.81022  -8.01554  1.000 18.61839 ? 295  ARG A CZ   1 
ATOM   1640 N NH1  . ARG A 1 115 ? -6.78103  12.06886  -8.38666  1.000 16.60486 ? 295  ARG A NH1  1 
ATOM   1641 N NH2  . ARG A 1 115 ? -5.87439  10.59745  -6.88728  1.000 22.58197 ? 295  ARG A NH2  1 
ATOM   1642 H H    . ARG A 1 115 ? -4.94914  11.14432  -13.45217 1.000 17.42901 ? 295  ARG A H    1 
ATOM   1643 H HA   . ARG A 1 115 ? -7.34169  10.53712  -14.42689 1.000 15.99046 ? 295  ARG A HA   1 
ATOM   1644 H HB2  . ARG A 1 115 ? -8.35664  10.08967  -12.34446 1.000 19.14407 ? 295  ARG A HB2  1 
ATOM   1645 H HB3  . ARG A 1 115 ? -7.30787  8.95767   -12.72403 1.000 19.14407 ? 295  ARG A HB3  1 
ATOM   1646 H HG2  . ARG A 1 115 ? -5.98745  9.46210   -11.08702 1.000 21.28364 ? 295  ARG A HG2  1 
ATOM   1647 H HG3  . ARG A 1 115 ? -6.41672  10.99218  -11.08550 1.000 21.28364 ? 295  ARG A HG3  1 
ATOM   1648 H HD2  . ARG A 1 115 ? -8.33498  10.52145  -9.94834  1.000 21.67340 ? 295  ARG A HD2  1 
ATOM   1649 H HD3  . ARG A 1 115 ? -8.10993  8.95791   -10.12189 1.000 21.67340 ? 295  ARG A HD3  1 
ATOM   1650 H HE   . ARG A 1 115 ? -6.87764  8.99158   -8.35693  1.000 23.70290 ? 295  ARG A HE   1 
ATOM   1651 H HH11 . ARG A 1 115 ? -7.25027  12.22543  -9.09015  1.000 19.92584 ? 295  ARG A HH11 1 
ATOM   1652 H HH12 . ARG A 1 115 ? -6.47105  12.72291  -7.92219  1.000 19.92584 ? 295  ARG A HH12 1 
ATOM   1653 H HH21 . ARG A 1 115 ? -5.74797  9.79391   -6.60809  1.000 27.09836 ? 295  ARG A HH21 1 
ATOM   1654 H HH22 . ARG A 1 115 ? -5.57254  11.26278  -6.43360  1.000 27.09836 ? 295  ARG A HH22 1 
ATOM   1655 N N    . THR A 1 116 ? -8.43800  12.55660  -13.25347 1.000 13.71149 ? 296  THR A N    1 
ATOM   1656 C CA   . THR A 1 116 ? -8.89676  13.83873  -12.75691 1.000 15.41284 ? 296  THR A CA   1 
ATOM   1657 C C    . THR A 1 116 ? -8.76474  13.90132  -11.24488 1.000 13.83899 ? 296  THR A C    1 
ATOM   1658 O O    . THR A 1 116 ? -8.60896  12.87856  -10.55675 1.000 14.18280 ? 296  THR A O    1 
ATOM   1659 C CB   . THR A 1 116 ? -10.37062 14.05176  -13.09310 1.000 12.38646 ? 296  THR A CB   1 
ATOM   1660 O OG1  . THR A 1 116 ? -11.17362 13.10119  -12.42465 1.000 13.79297 ? 296  THR A OG1  1 
ATOM   1661 C CG2  . THR A 1 116 ? -10.60534 13.94538  -14.59593 1.000 14.68820 ? 296  THR A CG2  1 
ATOM   1662 H H    . THR A 1 116 ? -9.07195  12.03873  -13.51713 1.000 16.45379 ? 296  THR A H    1 
ATOM   1663 H HA   . THR A 1 116 ? -8.35784  14.53097  -13.17075 1.000 18.49541 ? 296  THR A HA   1 
ATOM   1664 H HB   . THR A 1 116 ? -10.62943 14.94075  -12.80394 1.000 14.86375 ? 296  THR A HB   1 
ATOM   1665 H HG1  . THR A 1 116 ? -11.21256 13.28318  -11.60553 1.000 16.55156 ? 296  THR A HG1  1 
ATOM   1666 H HG21 . THR A 1 116 ? -11.53478 14.13281  -14.80064 1.000 17.62583 ? 296  THR A HG21 1 
ATOM   1667 H HG22 . THR A 1 116 ? -10.04487 14.58300  -15.06520 1.000 17.62583 ? 296  THR A HG22 1 
ATOM   1668 H HG23 . THR A 1 116 ? -10.38957 13.05089  -14.90292 1.000 17.62583 ? 296  THR A HG23 1 
ATOM   1669 N N    . LYS A 1 117 ? -8.88125  15.11872  -10.71270 1.000 14.94771 ? 297  LYS A N    1 
ATOM   1670 C CA   . LYS A 1 117 ? -9.23453  15.32213  -9.31319  1.000 14.49628 ? 297  LYS A CA   1 
ATOM   1671 C C    . LYS A 1 117 ? -10.59178 14.69055  -9.02279  1.000 15.06851 ? 297  LYS A C    1 
ATOM   1672 O O    . LYS A 1 117 ? -11.35476 14.30708  -9.92799  1.000 14.20609 ? 297  LYS A O    1 
ATOM   1673 C CB   . LYS A 1 117 ? -9.27706  16.82038  -9.00743  1.000 15.60231 ? 297  LYS A CB   1 
ATOM   1674 C CG   . LYS A 1 117 ? -7.90964  17.51696  -9.05207  1.000 17.55969 ? 297  LYS A CG   1 
ATOM   1675 C CD   . LYS A 1 117 ? -8.02763  18.98842  -8.72965  1.000 20.38301 ? 297  LYS A CD   1 
ATOM   1676 C CE   . LYS A 1 117 ? -6.67274  19.63592  -8.84152  1.000 22.90097 ? 297  LYS A CE   1 
ATOM   1677 N NZ   . LYS A 1 117 ? -6.75992  21.08501  -8.63752  1.000 28.75107 ? 297  LYS A NZ   1 
ATOM   1678 H H    . LYS A 1 117 ? -8.75900  15.85041  -11.14777 1.000 17.93725 ? 297  LYS A H    1 
ATOM   1679 H HA   . LYS A 1 117 ? -8.57332  14.90570  -8.73848  1.000 17.39554 ? 297  LYS A HA   1 
ATOM   1680 H HB2  . LYS A 1 117 ? -9.84810  17.25322  -9.66124  1.000 18.72277 ? 297  LYS A HB2  1 
ATOM   1681 H HB3  . LYS A 1 117 ? -9.64007  16.94386  -8.11643  1.000 18.72277 ? 297  LYS A HB3  1 
ATOM   1682 H HG2  . LYS A 1 117 ? -7.31929  17.10825  -8.39989  1.000 21.07163 ? 297  LYS A HG2  1 
ATOM   1683 H HG3  . LYS A 1 117 ? -7.53299  17.42893  -9.94161  1.000 21.07163 ? 297  LYS A HG3  1 
ATOM   1684 H HD2  . LYS A 1 117 ? -8.63192  19.41540  -9.35689  1.000 24.45961 ? 297  LYS A HD2  1 
ATOM   1685 H HD3  . LYS A 1 117 ? -8.35539  19.10164  -7.82375  1.000 24.45961 ? 297  LYS A HD3  1 
ATOM   1686 H HE2  . LYS A 1 117 ? -6.08216  19.26645  -8.16654  1.000 27.48116 ? 297  LYS A HE2  1 
ATOM   1687 H HE3  . LYS A 1 117 ? -6.30928  19.47231  -9.72585  1.000 27.48116 ? 297  LYS A HE3  1 
ATOM   1688 H HZ1  . LYS A 1 117 ? -7.08135  21.25938  -7.82612  1.000 34.50128 ? 297  LYS A HZ1  1 
ATOM   1689 H HZ2  . LYS A 1 117 ? -5.95277  21.45221  -8.71350  1.000 34.50128 ? 297  LYS A HZ2  1 
ATOM   1690 H HZ3  . LYS A 1 117 ? -7.29995  21.44610  -9.24586  1.000 34.50128 ? 297  LYS A HZ3  1 
ATOM   1691 N N    . ALA A 1 118 ? -10.90074 14.56549  -7.73472  1.000 14.00400 ? 298  ALA A N    1 
ATOM   1692 C CA   . ALA A 1 118 ? -12.20821 14.01247  -7.37629  1.000 14.36504 ? 298  ALA A CA   1 
ATOM   1693 C C    . ALA A 1 118 ? -13.28110 15.08729  -7.46776  1.000 14.20954 ? 298  ALA A C    1 
ATOM   1694 O O    . ALA A 1 118 ? -13.07668 16.21980  -7.02003  1.000 17.49987 ? 298  ALA A O    1 
ATOM   1695 C CB   . ALA A 1 118 ? -12.16987 13.40668  -5.97521  1.000 17.14400 ? 298  ALA A CB   1 
ATOM   1696 H H    . ALA A 1 118 ? -10.39339 14.78381  -7.07552  1.000 16.80480 ? 298  ALA A H    1 
ATOM   1697 H HA   . ALA A 1 118 ? -12.44207 13.30323  -7.99531  1.000 17.23804 ? 298  ALA A HA   1 
ATOM   1698 H HB1  . ALA A 1 118 ? -13.04660 13.05140  -5.76067  1.000 20.57279 ? 298  ALA A HB1  1 
ATOM   1699 H HB2  . ALA A 1 118 ? -11.51101 12.69503  -5.95677  1.000 20.57279 ? 298  ALA A HB2  1 
ATOM   1700 H HB3  . ALA A 1 118 ? -11.92823 14.09775  -5.33886  1.000 20.57279 ? 298  ALA A HB3  1 
ATOM   1701 N N    . MET A 1 119 ? -14.40799 14.73446  -8.04029  1.000 13.90452 ? 299  MET A N    1 
ATOM   1702 C CA   . MET A 1 119 ? -15.58833 15.60604  -8.06883  1.000 12.36674 ? 299  MET A CA   1 
ATOM   1703 C C    . MET A 1 119 ? -16.51919 15.15867  -6.96515  1.000 13.64387 ? 299  MET A C    1 
ATOM   1704 O O    . MET A 1 119 ? -17.11080 14.08462  -7.05335  1.000 15.58861 ? 299  MET A O    1 
ATOM   1705 C CB   . MET A 1 119 ? -16.30561 15.53558  -9.41904  1.000 15.50676 ? 299  MET A CB   1 
ATOM   1706 C CG   . MET A 1 119 ? -17.47291 16.53348  -9.54724  1.000 15.87340 ? 299  MET A CG   1 
ATOM   1707 S SD   . MET A 1 119 ? -18.41531 16.31884  -11.04309 1.000 15.76747 ? 299  MET A SD   1 
ATOM   1708 C CE   . MET A 1 119 ? -19.16004 14.68255  -10.84025 1.000 17.04515 ? 299  MET A CE   1 
ATOM   1709 H H    . MET A 1 119 ? -14.52942 13.97868  -8.43228  1.000 16.68543 ? 299  MET A H    1 
ATOM   1710 H HA   . MET A 1 119 ? -15.30265 16.52196  -7.92606  1.000 14.84008 ? 299  MET A HA   1 
ATOM   1711 H HB2  . MET A 1 119 ? -15.66769 15.73228  -10.12280 1.000 18.60812 ? 299  MET A HB2  1 
ATOM   1712 H HB3  . MET A 1 119 ? -16.66416 14.64197  -9.53655  1.000 18.60812 ? 299  MET A HB3  1 
ATOM   1713 H HG2  . MET A 1 119 ? -18.07422 16.41258  -8.79576  1.000 19.04807 ? 299  MET A HG2  1 
ATOM   1714 H HG3  . MET A 1 119 ? -17.11710 17.43586  -9.54558  1.000 19.04807 ? 299  MET A HG3  1 
ATOM   1715 H HE1  . MET A 1 119 ? -19.70214 14.48349  -11.61961 1.000 20.45418 ? 299  MET A HE1  1 
ATOM   1716 H HE2  . MET A 1 119 ? -18.45422 14.02318  -10.75110 1.000 20.45418 ? 299  MET A HE2  1 
ATOM   1717 H HE3  . MET A 1 119 ? -19.71376 14.68412  -10.04382 1.000 20.45418 ? 299  MET A HE3  1 
ATOM   1718 N N    . VAL A 1 120 ? -16.64685 15.96427  -5.92753  1.000 14.11132 ? 300  VAL A N    1 
ATOM   1719 C CA   . VAL A 1 120 ? -17.63389 15.73809  -4.87813  1.000 14.67078 ? 300  VAL A CA   1 
ATOM   1720 C C    . VAL A 1 120 ? -18.90708 16.41875  -5.35066  1.000 14.60426 ? 300  VAL A C    1 
ATOM   1721 O O    . VAL A 1 120 ? -18.90575 17.62838  -5.61225  1.000 16.21073 ? 300  VAL A O    1 
ATOM   1722 C CB   . VAL A 1 120 ? -17.16421 16.33277  -3.54223  1.000 15.50621 ? 300  VAL A CB   1 
ATOM   1723 C CG1  . VAL A 1 120 ? -18.23130 16.17989  -2.47005  1.000 16.98783 ? 300  VAL A CG1  1 
ATOM   1724 C CG2  . VAL A 1 120 ? -15.88485 15.68299  -3.11225  1.000 18.63330 ? 300  VAL A CG2  1 
ATOM   1725 H H    . VAL A 1 120 ? -16.16487 16.66535  -5.80188  1.000 16.93358 ? 300  VAL A H    1 
ATOM   1726 H HA   . VAL A 1 120 ? -17.78804 14.78962  -4.74572  1.000 17.60493 ? 300  VAL A HA   1 
ATOM   1727 H HB   . VAL A 1 120 ? -17.00433 17.28199  -3.66188  1.000 18.60745 ? 300  VAL A HB   1 
ATOM   1728 H HG11 . VAL A 1 120 ? -17.86051 16.44850  -1.61490  1.000 20.38539 ? 300  VAL A HG11 1 
ATOM   1729 H HG12 . VAL A 1 120 ? -18.98767 16.74416  -2.69454  1.000 20.38539 ? 300  VAL A HG12 1 
ATOM   1730 H HG13 . VAL A 1 120 ? -18.51064 15.25174  -2.43259  1.000 20.38539 ? 300  VAL A HG13 1 
ATOM   1731 H HG21 . VAL A 1 120 ? -15.66839 15.97603  -2.21327  1.000 22.35996 ? 300  VAL A HG21 1 
ATOM   1732 H HG22 . VAL A 1 120 ? -15.99906 14.71986  -3.12771  1.000 22.35996 ? 300  VAL A HG22 1 
ATOM   1733 H HG23 . VAL A 1 120 ? -15.17794 15.94211  -3.72383  1.000 22.35996 ? 300  VAL A HG23 1 
ATOM   1734 N N    . ALA A 1 121 ? -19.98683 15.65272  -5.48968  1.000 14.87380 ? 301  ALA A N    1 
ATOM   1735 C CA   . ALA A 1 121 ? -21.21584 16.14705  -6.06872  1.000 16.76999 ? 301  ALA A CA   1 
ATOM   1736 C C    . ALA A 1 121 ? -22.43263 15.88884  -5.18807  1.000 16.69758 ? 301  ALA A C    1 
ATOM   1737 O O    . ALA A 1 121 ? -22.61257 14.81100  -4.61340  1.000 16.95350 ? 301  ALA A O    1 
ATOM   1738 C CB   . ALA A 1 121 ? -21.48856 15.50360  -7.42604  1.000 16.80572 ? 301  ALA A CB   1 
ATOM   1739 H H    . ALA A 1 121 ? -20.02482 14.82800  -5.24885  1.000 17.84855 ? 301  ALA A H    1 
ATOM   1740 H HA   . ALA A 1 121 ? -21.11218 17.10790  -6.15194  1.000 20.12399 ? 301  ALA A HA   1 
ATOM   1741 H HB1  . ALA A 1 121 ? -22.32203 15.85228  -7.77907  1.000 20.16686 ? 301  ALA A HB1  1 
ATOM   1742 H HB2  . ALA A 1 121 ? -20.75910 15.71673  -8.02884  1.000 20.16686 ? 301  ALA A HB2  1 
ATOM   1743 H HB3  . ALA A 1 121 ? -21.55377 14.54247  -7.31250  1.000 20.16686 ? 301  ALA A HB3  1 
ATOM   1744 N N    . CYS A 1 122 ? -23.30577 16.87908  -5.15279  1.000 14.84681 ? 302  CYS A N    1 
ATOM   1745 C CA   . CYS A 1 122 ? -24.55741 16.79900  -4.41660  1.000 17.95917 ? 302  CYS A CA   1 
ATOM   1746 C C    . CYS A 1 122 ? -25.71910 17.15227  -5.32445  1.000 15.49219 ? 302  CYS A C    1 
ATOM   1747 O O    . CYS A 1 122 ? -25.73477 18.23397  -5.91955  1.000 15.71322 ? 302  CYS A O    1 
ATOM   1748 C CB   . CYS A 1 122 ? -24.51833 17.78134  -3.24550  1.000 15.88789 ? 302  CYS A CB   1 
ATOM   1749 S SG   . CYS A 1 122 ? -26.07868 18.02325  -2.41304  1.000 19.71776 ? 302  CYS A SG   1 
ATOM   1750 H H    . CYS A 1 122 ? -23.19431 17.62935  -5.55810  1.000 17.81617 ? 302  CYS A H    1 
ATOM   1751 H HA   . CYS A 1 122 ? -24.69433 15.89286  -4.09868  1.000 21.55101 ? 302  CYS A HA   1 
ATOM   1752 H HB2  . CYS A 1 122 ? -23.88600 17.45076  -2.58841  1.000 19.06547 ? 302  CYS A HB2  1 
ATOM   1753 H HB3  . CYS A 1 122 ? -24.22923 18.64517  -3.57885  1.000 19.06547 ? 302  CYS A HB3  1 
ATOM   1754 H HG   . CYS A 1 122 ? -26.03001 19.04154  -1.78001  1.000 23.66131 ? 302  CYS A HG   1 
ATOM   1755 N N    . TYR A 1 123 ? -26.71230 16.26738  -5.39261  1.000 16.46112 ? 303  TYR A N    1 
ATOM   1756 C CA   . TYR A 1 123 ? -28.01522 16.63420  -5.92502  1.000 17.56881 ? 303  TYR A CA   1 
ATOM   1757 C C    . TYR A 1 123 ? -28.86840 16.99619  -4.73280  1.000 18.89282 ? 303  TYR A C    1 
ATOM   1758 O O    . TYR A 1 123 ? -29.15556 16.11938  -3.90861  1.000 19.89559 ? 303  TYR A O    1 
ATOM   1759 C CB   . TYR A 1 123 ? -28.61350 15.46279  -6.67960  1.000 18.35261 ? 303  TYR A CB   1 
ATOM   1760 C CG   . TYR A 1 123 ? -27.85586 15.15097  -7.94605  1.000 17.30654 ? 303  TYR A CG   1 
ATOM   1761 C CD1  . TYR A 1 123 ? -26.70550 14.34896  -7.92874  1.000 16.17036 ? 303  TYR A CD1  1 
ATOM   1762 C CD2  . TYR A 1 123 ? -28.29912 15.65986  -9.16876  1.000 17.77610 ? 303  TYR A CD2  1 
ATOM   1763 C CE1  . TYR A 1 123 ? -26.00669 14.04254  -9.10439  1.000 15.38580 ? 303  TYR A CE1  1 
ATOM   1764 C CE2  . TYR A 1 123 ? -27.60546 15.35629  -10.34273 1.000 18.00891 ? 303  TYR A CE2  1 
ATOM   1765 C CZ   . TYR A 1 123 ? -26.47807 14.56661  -10.30170 1.000 16.93506 ? 303  TYR A CZ   1 
ATOM   1766 O OH   . TYR A 1 123 ? -25.76060 14.25313  -11.45084 1.000 17.55384 ? 303  TYR A OH   1 
ATOM   1767 H H    . TYR A 1 123 ? -26.65320 15.44872  -5.13588  1.000 19.75335 ? 303  TYR A H    1 
ATOM   1768 H HA   . TYR A 1 123 ? -27.95934 17.38641  -6.53489  1.000 21.08257 ? 303  TYR A HA   1 
ATOM   1769 H HB2  . TYR A 1 123 ? -28.59204 14.67580  -6.11295  1.000 22.02313 ? 303  TYR A HB2  1 
ATOM   1770 H HB3  . TYR A 1 123 ? -29.52933 15.67403  -6.91945  1.000 22.02313 ? 303  TYR A HB3  1 
ATOM   1771 H HD1  . TYR A 1 123 ? -26.39902 14.01239  -7.11776  1.000 19.40443 ? 303  TYR A HD1  1 
ATOM   1772 H HD2  . TYR A 1 123 ? -29.05530 16.20026  -9.20140  1.000 21.33132 ? 303  TYR A HD2  1 
ATOM   1773 H HE1  . TYR A 1 123 ? -25.24897 13.50371  -9.08364  1.000 18.46296 ? 303  TYR A HE1  1 
ATOM   1774 H HE2  . TYR A 1 123 ? -27.90689 15.68955  -11.15696 1.000 21.61070 ? 303  TYR A HE2  1 
ATOM   1775 H HH   . TYR A 1 123 ? -26.00382 14.74723  -12.08512 1.000 21.06461 ? 303  TYR A HH   1 
ATOM   1776 N N    . PRO A 1 124 ? -29.26095 18.25532  -4.56959  1.000 19.48235 ? 304  PRO A N    1 
ATOM   1777 C CA   . PRO A 1 124 ? -29.87612 18.69966  -3.31110  1.000 20.39844 ? 304  PRO A CA   1 
ATOM   1778 C C    . PRO A 1 124 ? -31.37440 18.45639  -3.29156  1.000 22.36826 ? 304  PRO A C    1 
ATOM   1779 O O    . PRO A 1 124 ? -32.17686 19.37718  -3.08101  1.000 24.14328 ? 304  PRO A O    1 
ATOM   1780 C CB   . PRO A 1 124 ? -29.60156 20.20429  -3.30538  1.000 20.20954 ? 304  PRO A CB   1 
ATOM   1781 C CG   . PRO A 1 124 ? -29.62100 20.56167  -4.74554  1.000 21.01195 ? 304  PRO A CG   1 
ATOM   1782 C CD   . PRO A 1 124 ? -29.00315 19.40522  -5.47821  1.000 18.55416 ? 304  PRO A CD   1 
ATOM   1783 H HA   . PRO A 1 124 ? -29.43819 18.27133  -2.55901  1.000 24.47813 ? 304  PRO A HA   1 
ATOM   1784 H HB2  . PRO A 1 124 ? -30.29667 20.67163  -2.81618  1.000 24.25145 ? 304  PRO A HB2  1 
ATOM   1785 H HB3  . PRO A 1 124 ? -28.73587 20.38717  -2.90784  1.000 24.25145 ? 304  PRO A HB3  1 
ATOM   1786 H HG2  . PRO A 1 124 ? -30.53697 20.69851  -5.03395  1.000 25.21434 ? 304  PRO A HG2  1 
ATOM   1787 H HG3  . PRO A 1 124 ? -29.10444 21.37048  -4.88655  1.000 25.21434 ? 304  PRO A HG3  1 
ATOM   1788 H HD2  . PRO A 1 124 ? -29.43268 19.27053  -6.33743  1.000 22.26499 ? 304  PRO A HD2  1 
ATOM   1789 H HD3  . PRO A 1 124 ? -28.05082 19.54241  -5.60126  1.000 22.26499 ? 304  PRO A HD3  1 
ATOM   1790 N N    . GLY A 1 125 ? -31.76680 17.22903  -3.56587  1.000 17.63847 ? 305  GLY A N    1 
ATOM   1791 C CA   . GLY A 1 125 ? -33.17554 16.90716  -3.57496  1.000 19.72507 ? 305  GLY A CA   1 
ATOM   1792 C C    . GLY A 1 125 ? -33.90711 17.75051  -4.60713  1.000 23.73276 ? 305  GLY A C    1 
ATOM   1793 O O    . GLY A 1 125 ? -33.36083 18.11071  -5.67192  1.000 20.90723 ? 305  GLY A O    1 
ATOM   1794 H H    . GLY A 1 125 ? -31.24353 16.57133  -3.74817  1.000 21.16616 ? 305  GLY A H    1 
ATOM   1795 H HA2  . GLY A 1 125 ? -33.29711 15.96978  -3.79274  1.000 23.67009 ? 305  GLY A HA2  1 
ATOM   1796 H HA3  . GLY A 1 125 ? -33.55789 17.08037  -2.70048  1.000 23.67009 ? 305  GLY A HA3  1 
ATOM   1797 N N    . ASN A 1 126 ? -35.17331 18.04798  -4.30559  1.000 24.08693 ? 306  ASN A N    1 
ATOM   1798 C CA   . ASN A 1 126 ? -35.96753 18.93739  -5.13524  1.000 22.94345 ? 306  ASN A CA   1 
ATOM   1799 C C    . ASN A 1 126 ? -36.10758 18.47288  -6.56935  1.000 21.42260 ? 306  ASN A C    1 
ATOM   1800 O O    . ASN A 1 126 ? -36.41855 19.27675  -7.45687  1.000 24.90499 ? 306  ASN A O    1 
ATOM   1801 C CB   . ASN A 1 126 ? -35.39826 20.34486  -5.05447  1.000 21.18353 ? 306  ASN A CB   1 
ATOM   1802 C CG   . ASN A 1 126 ? -35.43334 20.87986  -3.64983  1.000 23.83058 ? 306  ASN A CG   1 
ATOM   1803 O OD1  . ASN A 1 126 ? -36.40369 20.65511  -2.91233  1.000 27.03220 ? 306  ASN A OD1  1 
ATOM   1804 N ND2  . ASN A 1 126 ? -34.35766 21.56295  -3.25031  1.000 26.01809 ? 306  ASN A ND2  1 
ATOM   1805 H H    . ASN A 1 126 ? -35.59095 17.74123  -3.61924  1.000 28.90432 ? 306  ASN A H    1 
ATOM   1806 H HA   . ASN A 1 126 ? -36.87675 18.94955  -4.79749  1.000 27.53214 ? 306  ASN A HA   1 
ATOM   1807 H HB2  . ASN A 1 126 ? -34.47545 20.33445  -5.35313  1.000 25.42023 ? 306  ASN A HB2  1 
ATOM   1808 H HB3  . ASN A 1 126 ? -35.92271 20.93501  -5.61801  1.000 25.42023 ? 306  ASN A HB3  1 
ATOM   1809 H HD21 . ASN A 1 126 ? -33.69570 21.67544  -3.78767  1.000 31.22170 ? 306  ASN A HD21 1 
ATOM   1810 H HD22 . ASN A 1 126 ? -34.32689 21.89036  -2.45567  1.000 31.22170 ? 306  ASN A HD22 1 
ATOM   1811 N N    . GLY A 1 127 ? -35.96561 17.17526  -6.80121  1.000 20.53511 ? 307  GLY A N    1 
ATOM   1812 C CA   . GLY A 1 127 ? -36.12567 16.65271  -8.11772  1.000 19.74009 ? 307  GLY A CA   1 
ATOM   1813 C C    . GLY A 1 127 ? -34.96217 16.87623  -9.04682  1.000 21.96766 ? 307  GLY A C    1 
ATOM   1814 O O    . GLY A 1 127 ? -35.09728 16.62286  -10.25018 1.000 23.18116 ? 307  GLY A O    1 
ATOM   1815 H H    . GLY A 1 127 ? -35.77633 16.58782  -6.20231  1.000 24.64213 ? 307  GLY A H    1 
ATOM   1816 H HA2  . GLY A 1 127 ? -36.27099 15.69577  -8.05419  1.000 23.68811 ? 307  GLY A HA2  1 
ATOM   1817 H HA3  . GLY A 1 127 ? -36.90616 17.06462  -8.52030  1.000 23.68811 ? 307  GLY A HA3  1 
ATOM   1818 N N    . THR A 1 128 ? -33.82274 17.33454  -8.53869  1.000 20.05602 ? 308  THR A N    1 
ATOM   1819 C CA   . THR A 1 128 ? -32.63565 17.53219  -9.36765  1.000 20.97780 ? 308  THR A CA   1 
ATOM   1820 C C    . THR A 1 128 ? -32.11405 16.17683  -9.87714  1.000 20.31718 ? 308  THR A C    1 
ATOM   1821 O O    . THR A 1 128 ? -32.23650 15.13726  -9.22456  1.000 19.82049 ? 308  THR A O    1 
ATOM   1822 C CB   . THR A 1 128 ? -31.53208 18.29561  -8.58607  1.000 18.67482 ? 308  THR A CB   1 
ATOM   1823 O OG1  . THR A 1 128 ? -31.17164 17.55783  -7.37516  1.000 20.58944 ? 308  THR A OG1  1 
ATOM   1824 C CG2  . THR A 1 128 ? -31.98128 19.70376  -8.19037  1.000 22.73196 ? 308  THR A CG2  1 
ATOM   1825 H H    . THR A 1 128 ? -33.70822 17.54048  -7.71161  1.000 24.06723 ? 308  THR A H    1 
ATOM   1826 H HA   . THR A 1 128 ? -32.86077 18.07677  -10.13814 1.000 25.17337 ? 308  THR A HA   1 
ATOM   1827 H HB   . THR A 1 128 ? -30.75869 18.38026  -9.16538  1.000 22.40978 ? 308  THR A HB   1 
ATOM   1828 H HG1  . THR A 1 128 ? -31.84515 17.47033  -6.88087  1.000 24.70733 ? 308  THR A HG1  1 
ATOM   1829 H HG21 . THR A 1 128 ? -31.25669 20.17028  -7.74515  1.000 27.27836 ? 308  THR A HG21 1 
ATOM   1830 H HG22 . THR A 1 128 ? -32.23930 20.20395  -8.98039  1.000 27.27836 ? 308  THR A HG22 1 
ATOM   1831 H HG23 . THR A 1 128 ? -32.74002 19.65300  -7.58819  1.000 27.27836 ? 308  THR A HG23 1 
ATOM   1832 N N    . GLY A 1 129 ? -31.49713 16.21194  -11.05588 1.000 18.51415 ? 309  GLY A N    1 
ATOM   1833 C CA   . GLY A 1 129 ? -30.90464 15.04576  -11.66477 1.000 15.31012 ? 309  GLY A CA   1 
ATOM   1834 C C    . GLY A 1 129 ? -30.00657 15.45197  -12.79814 1.000 16.57012 ? 309  GLY A C    1 
ATOM   1835 O O    . GLY A 1 129 ? -29.54138 16.58441  -12.86563 1.000 16.19260 ? 309  GLY A O    1 
ATOM   1836 H H    . GLY A 1 129 ? -31.40950 16.92323  -11.53125 1.000 22.21698 ? 309  GLY A H    1 
ATOM   1837 H HA2  . GLY A 1 129 ? -30.38193 14.56020  -11.00758 1.000 18.37214 ? 309  GLY A HA2  1 
ATOM   1838 H HA3  . GLY A 1 129 ? -31.60040 14.46338  -12.00779 1.000 18.37214 ? 309  GLY A HA3  1 
ATOM   1839 N N    . TYR A 1 130 ? -29.78262 14.53508  -13.71310 1.000 14.38678 ? 310  TYR A N    1 
ATOM   1840 C CA   . TYR A 1 130 ? -28.85145 14.77337  -14.82895 1.000 14.19049 ? 310  TYR A CA   1 
ATOM   1841 C C    . TYR A 1 130 ? -29.44199 14.03931  -16.03136 1.000 16.11683 ? 310  TYR A C    1 
ATOM   1842 O O    . TYR A 1 130 ? -29.63070 12.81567  -15.98061 1.000 15.62746 ? 310  TYR A O    1 
ATOM   1843 C CB   . TYR A 1 130 ? -27.45387 14.23940  -14.48205 1.000 15.81866 ? 310  TYR A CB   1 
ATOM   1844 C CG   . TYR A 1 130 ? -26.27320 14.77595  -15.26753 1.000 14.22288 ? 310  TYR A CG   1 
ATOM   1845 C CD1  . TYR A 1 130 ? -26.38555 15.14056  -16.61211 1.000 13.91157 ? 310  TYR A CD1  1 
ATOM   1846 C CD2  . TYR A 1 130 ? -25.03834 14.84202  -14.67103 1.000 15.00198 ? 310  TYR A CD2  1 
ATOM   1847 C CE1  . TYR A 1 130 ? -25.28068 15.59921  -17.32796 1.000 15.12469 ? 310  TYR A CE1  1 
ATOM   1848 C CE2  . TYR A 1 130 ? -23.91542 15.29938  -15.37778 1.000 15.40365 ? 310  TYR A CE2  1 
ATOM   1849 C CZ   . TYR A 1 130 ? -24.06039 15.67013  -16.69763 1.000 14.36277 ? 310  TYR A CZ   1 
ATOM   1850 O OH   . TYR A 1 130 ? -22.94267 16.10801  -17.39950 1.000 14.83311 ? 310  TYR A OH   1 
ATOM   1851 H H    . TYR A 1 130 ? -30.15254 13.75876  -13.72222 1.000 17.26414 ? 310  TYR A H    1 
ATOM   1852 H HA   . TYR A 1 130 ? -28.76370 15.71720  -15.03483 1.000 17.02859 ? 310  TYR A HA   1 
ATOM   1853 H HB2  . TYR A 1 130 ? -27.28285 14.44312  -13.54923 1.000 18.98239 ? 310  TYR A HB2  1 
ATOM   1854 H HB3  . TYR A 1 130 ? -27.46308 13.27868  -14.61554 1.000 18.98239 ? 310  TYR A HB3  1 
ATOM   1855 H HD1  . TYR A 1 130 ? -27.21075 15.07616  -17.03614 1.000 16.69389 ? 310  TYR A HD1  1 
ATOM   1856 H HD2  . TYR A 1 130 ? -24.94445 14.57933  -13.78385 1.000 18.00237 ? 310  TYR A HD2  1 
ATOM   1857 H HE1  . TYR A 1 130 ? -25.36750 15.85340  -18.21833 1.000 18.14963 ? 310  TYR A HE1  1 
ATOM   1858 H HE2  . TYR A 1 130 ? -23.08535 15.35160  -14.96167 1.000 18.48438 ? 310  TYR A HE2  1 
ATOM   1859 H HH   . TYR A 1 130 ? -23.17548 16.42474  -18.14185 1.000 17.79973 ? 310  TYR A HH   1 
ATOM   1860 N N    . VAL A 1 131 ? -29.77665 14.77578  -17.07402 1.000 15.41904 ? 311  VAL A N    1 
ATOM   1861 C CA   . VAL A 1 131 ? -30.36302 14.17990  -18.26255 1.000 15.98976 ? 311  VAL A CA   1 
ATOM   1862 C C    . VAL A 1 131 ? -29.40296 13.13605  -18.84999 1.000 15.81170 ? 311  VAL A C    1 
ATOM   1863 O O    . VAL A 1 131 ? -28.19162 13.12434  -18.57598 1.000 15.42079 ? 311  VAL A O    1 
ATOM   1864 C CB   . VAL A 1 131 ? -30.67909 15.25086  -19.31988 1.000 16.86107 ? 311  VAL A CB   1 
ATOM   1865 C CG1  . VAL A 1 131 ? -31.67352 16.26681  -18.82852 1.000 17.52672 ? 311  VAL A CG1  1 
ATOM   1866 C CG2  . VAL A 1 131 ? -29.38781 15.92970  -19.75466 1.000 18.75559 ? 311  VAL A CG2  1 
ATOM   1867 H H    . VAL A 1 131 ? -29.67543 15.62842  -17.12262 1.000 18.50284 ? 311  VAL A H    1 
ATOM   1868 H HA   . VAL A 1 131 ? -31.18881 13.73778  -18.01057 1.000 19.18771 ? 311  VAL A HA   1 
ATOM   1869 H HB   . VAL A 1 131 ? -31.08902 14.81378  -20.08265 1.000 20.23329 ? 311  VAL A HB   1 
ATOM   1870 H HG11 . VAL A 1 131 ? -31.85599 16.90001  -19.54032 1.000 21.03206 ? 311  VAL A HG11 1 
ATOM   1871 H HG12 . VAL A 1 131 ? -32.49095 15.81100  -18.57368 1.000 21.03206 ? 311  VAL A HG12 1 
ATOM   1872 H HG13 . VAL A 1 131 ? -31.29996 16.72932  -18.06208 1.000 21.03206 ? 311  VAL A HG13 1 
ATOM   1873 H HG21 . VAL A 1 131 ? -29.60438 16.68848  -20.31880 1.000 22.50671 ? 311  VAL A HG21 1 
ATOM   1874 H HG22 . VAL A 1 131 ? -28.90789 16.22955  -18.96684 1.000 22.50671 ? 311  VAL A HG22 1 
ATOM   1875 H HG23 . VAL A 1 131 ? -28.84752 15.29356  -20.24894 1.000 22.50671 ? 311  VAL A HG23 1 
ATOM   1876 N N    . ARG A 1 132 ? -29.95468 12.26003  -19.69235 1.000 17.18570 ? 312  ARG A N    1 
ATOM   1877 C CA   . ARG A 1 132 ? -29.13911 11.20713  -20.29972 1.000 17.43331 ? 312  ARG A CA   1 
ATOM   1878 C C    . ARG A 1 132 ? -27.96091 11.79557  -21.07294 1.000 15.87391 ? 312  ARG A C    1 
ATOM   1879 O O    . ARG A 1 132 ? -28.12444 12.72671  -21.86937 1.000 18.89831 ? 312  ARG A O    1 
ATOM   1880 C CB   . ARG A 1 132 ? -30.03387 10.37868  -21.21434 1.000 22.54070 ? 312  ARG A CB   1 
ATOM   1881 C CG   . ARG A 1 132 ? -29.38859 9.12908   -21.78280 1.000 17.17665 ? 312  ARG A CG   1 
ATOM   1882 C CD   . ARG A 1 132 ? -30.23761 8.77256   -22.98598 1.000 32.00428 ? 312  ARG A CD   1 
ATOM   1883 N NE   . ARG A 1 132 ? -29.95272 7.45021   -23.50512 1.000 46.71071 ? 312  ARG A NE   1 
ATOM   1884 C CZ   . ARG A 1 132 ? -29.15893 7.22451   -24.54073 1.000 50.21772 ? 312  ARG A CZ   1 
ATOM   1885 N NH1  . ARG A 1 132 ? -28.50934 8.21595   -25.13036 1.000 39.94158 ? 312  ARG A NH1  1 
ATOM   1886 N NH2  . ARG A 1 132 ? -28.98488 5.96934   -24.97340 1.000 29.33473 ? 312  ARG A NH2  1 
ATOM   1887 H H    . ARG A 1 132 ? -30.78280 12.25363  -19.92426 1.000 20.62284 ? 312  ARG A H    1 
ATOM   1888 H HA   . ARG A 1 132 ? -28.76298 10.63467  -19.61291 1.000 20.91997 ? 312  ARG A HA   1 
ATOM   1889 H HB2  . ARG A 1 132 ? -30.81381 10.09935  -20.70979 1.000 27.04884 ? 312  ARG A HB2  1 
ATOM   1890 H HB3  . ARG A 1 132 ? -30.30417 10.93274  -21.96324 1.000 27.04884 ? 312  ARG A HB3  1 
ATOM   1891 H HG2  . ARG A 1 132 ? -28.47582 9.30528   -22.05974 1.000 20.61198 ? 312  ARG A HG2  1 
ATOM   1892 H HG3  . ARG A 1 132 ? -29.40554 8.40545   -21.13706 1.000 20.61198 ? 312  ARG A HG3  1 
ATOM   1893 H HD2  . ARG A 1 132 ? -31.17317 8.79873   -22.73115 1.000 38.40514 ? 312  ARG A HD2  1 
ATOM   1894 H HD3  . ARG A 1 132 ? -30.06832 9.41446   -23.69323 1.000 38.40514 ? 312  ARG A HD3  1 
ATOM   1895 H HE   . ARG A 1 132 ? -30.31937 6.77463   -23.11942 1.000 56.05285 ? 312  ARG A HE   1 
ATOM   1896 H HH11 . ARG A 1 132 ? -28.59966 9.02099   -24.84165 1.000 47.92989 ? 312  ARG A HH11 1 
ATOM   1897 H HH12 . ARG A 1 132 ? -27.99704 8.05496   -25.80209 1.000 47.92989 ? 312  ARG A HH12 1 
ATOM   1898 H HH21 . ARG A 1 132 ? -29.38679 5.31908   -24.57942 1.000 35.20168 ? 312  ARG A HH21 1 
ATOM   1899 H HH22 . ARG A 1 132 ? -28.47118 5.81346   -25.64527 1.000 35.20168 ? 312  ARG A HH22 1 
ATOM   1900 N N    . HIS A 1 133 ? -26.78656 11.24829  -20.82767 1.000 14.75371 ? 313  HIS A N    1 
ATOM   1901 C CA   . HIS A 1 133 ? -25.55573 11.75433  -21.41847 1.000 14.55057 ? 313  HIS A CA   1 
ATOM   1902 C C    . HIS A 1 133 ? -24.46127 10.69842  -21.42484 1.000 13.57459 ? 313  HIS A C    1 
ATOM   1903 O O    . HIS A 1 133 ? -24.58796 9.63116   -20.80665 1.000 14.94901 ? 313  HIS A O    1 
ATOM   1904 C CB   . HIS A 1 133 ? -25.02971 12.96816  -20.63733 1.000 14.71933 ? 313  HIS A CB   1 
ATOM   1905 C CG   . HIS A 1 133 ? -24.62190 12.64913  -19.24001 1.000 13.47846 ? 313  HIS A CG   1 
ATOM   1906 N ND1  . HIS A 1 133 ? -25.54156 12.46182  -18.23682 1.000 14.74248 ? 313  HIS A ND1  1 
ATOM   1907 C CD2  . HIS A 1 133 ? -23.40411 12.49286  -18.66483 1.000 14.51644 ? 313  HIS A CD2  1 
ATOM   1908 C CE1  . HIS A 1 133 ? -24.91197 12.19868  -17.09855 1.000 16.97999 ? 313  HIS A CE1  1 
ATOM   1909 N NE2  . HIS A 1 133 ? -23.61152 12.17084  -17.33821 1.000 14.69102 ? 313  HIS A NE2  1 
ATOM   1910 H H    . HIS A 1 133 ? -26.66927 10.56939  -20.31295 1.000 17.70445 ? 313  HIS A H    1 
ATOM   1911 H HA   . HIS A 1 133 ? -25.76808 11.98012  -22.33762 1.000 17.46068 ? 313  HIS A HA   1 
ATOM   1912 H HB2  . HIS A 1 133 ? -24.25417 13.32410  -21.09856 1.000 17.66320 ? 313  HIS A HB2  1 
ATOM   1913 H HB3  . HIS A 1 133 ? -25.72844 13.63972  -20.59623 1.000 17.66320 ? 313  HIS A HB3  1 
ATOM   1914 H HD1  . HIS A 1 133 ? -26.39504 12.50804  -18.33192 1.000 17.69098 ? 313  HIS A HD1  1 
ATOM   1915 H HD2  . HIS A 1 133 ? -22.58035 12.58554  -19.08641 1.000 17.41973 ? 313  HIS A HD2  1 
ATOM   1916 H HE1  . HIS A 1 133 ? -25.31631 12.05784  -16.27298 1.000 20.37598 ? 313  HIS A HE1  1 
ATOM   1917 N N    . VAL A 1 134 ? -23.37118 11.01873  -22.11827 1.000 15.17086 ? 314  VAL A N    1 
ATOM   1918 C CA   . VAL A 1 134 ? -22.14124 10.23376  -22.17600 1.000 15.13982 ? 314  VAL A CA   1 
ATOM   1919 C C    . VAL A 1 134 ? -21.05764 11.04293  -21.49197 1.000 14.46552 ? 314  VAL A C    1 
ATOM   1920 O O    . VAL A 1 134 ? -20.98273 12.25422  -21.68349 1.000 15.19538 ? 314  VAL A O    1 
ATOM   1921 C CB   . VAL A 1 134 ? -21.81969 9.95135   -23.65121 1.000 14.50266 ? 314  VAL A CB   1 
ATOM   1922 C CG1  . VAL A 1 134 ? -20.41522 9.41081   -23.81537 1.000 14.50292 ? 314  VAL A CG1  1 
ATOM   1923 C CG2  . VAL A 1 134 ? -22.86970 9.05223   -24.27715 1.000 16.46834 ? 314  VAL A CG2  1 
ATOM   1924 H H    . VAL A 1 134 ? -23.31713 11.73304  -22.59413 1.000 18.20503 ? 314  VAL A H    1 
ATOM   1925 H HA   . VAL A 1 134 ? -22.21192 9.39039   -21.70205 1.000 18.16778 ? 314  VAL A HA   1 
ATOM   1926 H HB   . VAL A 1 134 ? -21.84712 10.78884  -24.13985 1.000 17.40319 ? 314  VAL A HB   1 
ATOM   1927 H HG11 . VAL A 1 134 ? -20.30651 9.08426   -24.72226 1.000 17.40350 ? 314  VAL A HG11 1 
ATOM   1928 H HG12 . VAL A 1 134 ? -19.78032 10.12338  -23.64205 1.000 17.40350 ? 314  VAL A HG12 1 
ATOM   1929 H HG13 . VAL A 1 134 ? -20.27987 8.68649   -23.18454 1.000 17.40350 ? 314  VAL A HG13 1 
ATOM   1930 H HG21 . VAL A 1 134 ? -22.65435 8.91967   -25.21360 1.000 19.76201 ? 314  VAL A HG21 1 
ATOM   1931 H HG22 . VAL A 1 134 ? -22.87198 8.19974   -23.81437 1.000 19.76201 ? 314  VAL A HG22 1 
ATOM   1932 H HG23 . VAL A 1 134 ? -23.73833 9.47592   -24.19424 1.000 19.76201 ? 314  VAL A HG23 1 
ATOM   1933 N N    . ASP A 1 135 ? -20.24653 10.40383  -20.67002 1.000 13.57753 ? 315  ASP A N    1 
ATOM   1934 C CA   . ASP A 1 135 ? -19.24256 11.14822  -19.92968 1.000 13.93353 ? 315  ASP A CA   1 
ATOM   1935 C C    . ASP A 1 135 ? -18.17601 11.69930  -20.86663 1.000 13.74884 ? 315  ASP A C    1 
ATOM   1936 O O    . ASP A 1 135 ? -17.71717 12.83694  -20.70162 1.000 15.88475 ? 315  ASP A O    1 
ATOM   1937 C CB   . ASP A 1 135 ? -18.64057 10.28019  -18.86611 1.000 14.10903 ? 315  ASP A CB   1 
ATOM   1938 C CG   . ASP A 1 135 ? -19.41266 10.29420  -17.55995 1.000 15.88650 ? 315  ASP A CG   1 
ATOM   1939 O OD1  . ASP A 1 135 ? -20.46297 10.96791  -17.46617 1.000 15.26363 ? 315  ASP A OD1  1 
ATOM   1940 O OD2  . ASP A 1 135 ? -19.00361 9.58509   -16.63413 1.000 14.93548 ? 315  ASP A OD2  1 
ATOM   1941 H H    . ASP A 1 135 ? -20.25422 9.55638   -20.52382 1.000 16.29303 ? 315  ASP A H    1 
ATOM   1942 H HA   . ASP A 1 135 ? -19.66279 11.90089  -19.48494 1.000 16.72023 ? 315  ASP A HA   1 
ATOM   1943 H HB2  . ASP A 1 135 ? -18.61651 9.36481   -19.18612 1.000 16.93084 ? 315  ASP A HB2  1 
ATOM   1944 H HB3  . ASP A 1 135 ? -17.74041 10.59082  -18.68139 1.000 16.93084 ? 315  ASP A HB3  1 
ATOM   1945 N N    . ASN A 1 136 ? -17.73890 10.89251  -21.84306 1.000 13.77402 ? 316  ASN A N    1 
ATOM   1946 C CA   . ASN A 1 136 ? -16.68549 11.32782  -22.76275 1.000 14.31339 ? 316  ASN A CA   1 
ATOM   1947 C C    . ASN A 1 136 ? -17.07512 10.90814  -24.16300 1.000 13.86301 ? 316  ASN A C    1 
ATOM   1948 O O    . ASN A 1 136 ? -16.70242 9.83103   -24.63210 1.000 15.18259 ? 316  ASN A O    1 
ATOM   1949 C CB   . ASN A 1 136 ? -15.32037 10.74690  -22.39434 1.000 13.85809 ? 316  ASN A CB   1 
ATOM   1950 C CG   . ASN A 1 136 ? -14.28029 10.95941  -23.47958 1.000 15.44855 ? 316  ASN A CG   1 
ATOM   1951 O OD1  . ASN A 1 136 ? -14.38722 11.87840  -24.28008 1.000 17.83587 ? 316  ASN A OD1  1 
ATOM   1952 N ND2  . ASN A 1 136 ? -13.27668 10.08010  -23.55116 1.000 15.71126 ? 316  ASN A ND2  1 
ATOM   1953 H H    . ASN A 1 136 ? -18.03522 10.09845  -21.98890 1.000 16.52882 ? 316  ASN A H    1 
ATOM   1954 H HA   . ASN A 1 136 ? -16.61862 12.29475  -22.72424 1.000 17.17606 ? 316  ASN A HA   1 
ATOM   1955 H HB2  . ASN A 1 136 ? -15.00181 11.17658  -21.58515 1.000 16.62971 ? 316  ASN A HB2  1 
ATOM   1956 H HB3  . ASN A 1 136 ? -15.41174 9.79220   -22.24911 1.000 16.62971 ? 316  ASN A HB3  1 
ATOM   1957 H HD21 . ASN A 1 136 ? -13.23825 9.42525   -22.99502 1.000 18.85351 ? 316  ASN A HD21 1 
ATOM   1958 H HD22 . ASN A 1 136 ? -12.66919 10.16903  -24.15336 1.000 18.85351 ? 316  ASN A HD22 1 
ATOM   1959 N N    . PRO A 1 137 ? -17.85368 11.73670  -24.86295 1.000 13.94908 ? 317  PRO A N    1 
ATOM   1960 C CA   . PRO A 1 137 ? -18.32000 11.36731  -26.20228 1.000 16.23937 ? 317  PRO A CA   1 
ATOM   1961 C C    . PRO A 1 137 ? -17.33882 11.66297  -27.31678 1.000 18.43958 ? 317  PRO A C    1 
ATOM   1962 O O    . PRO A 1 137 ? -17.43426 11.03685  -28.39081 1.000 22.45838 ? 317  PRO A O    1 
ATOM   1963 C CB   . PRO A 1 137 ? -19.58997 12.21912  -26.37536 1.000 16.68780 ? 317  PRO A CB   1 
ATOM   1964 C CG   . PRO A 1 137 ? -19.32528 13.42175  -25.55519 1.000 17.14839 ? 317  PRO A CG   1 
ATOM   1965 C CD   . PRO A 1 137 ? -18.55709 12.93707  -24.33838 1.000 15.05025 ? 317  PRO A CD   1 
ATOM   1966 H HA   . PRO A 1 137 ? -18.54446 10.42375  -26.21689 1.000 19.48724 ? 317  PRO A HA   1 
ATOM   1967 H HB2  . PRO A 1 137 ? -19.71274 12.45095  -27.30921 1.000 20.02535 ? 317  PRO A HB2  1 
ATOM   1968 H HB3  . PRO A 1 137 ? -20.36465 11.73505  -26.04908 1.000 20.02535 ? 317  PRO A HB3  1 
ATOM   1969 H HG2  . PRO A 1 137 ? -18.79617 14.05492  -26.06513 1.000 20.57807 ? 317  PRO A HG2  1 
ATOM   1970 H HG3  . PRO A 1 137 ? -20.16539 13.82833  -25.29099 1.000 20.57807 ? 317  PRO A HG3  1 
ATOM   1971 H HD2  . PRO A 1 137 ? -17.92465 13.60728  -24.03553 1.000 18.06030 ? 317  PRO A HD2  1 
ATOM   1972 H HD3  . PRO A 1 137 ? -19.16040 12.70012  -23.61673 1.000 18.06030 ? 317  PRO A HD3  1 
ATOM   1973 N N    . ASN A 1 138 ? -16.38803 12.57630  -27.10405 0.983 17.67020 ? 318  ASN A N    1 
ATOM   1974 C CA   . ASN A 1 138 ? -15.59816 13.12733  -28.19990 0.983 20.84258 ? 318  ASN A CA   1 
ATOM   1975 C C    . ASN A 1 138 ? -14.09984 13.00896  -27.94572 0.983 21.40198 ? 318  ASN A C    1 
ATOM   1976 O O    . ASN A 1 138 ? -13.32873 13.82281  -28.46536 0.983 23.69660 ? 318  ASN A O    1 
ATOM   1977 C CB   . ASN A 1 138 ? -15.98373 14.59023  -28.45348 0.983 22.71073 ? 318  ASN A CB   1 
ATOM   1978 C CG   . ASN A 1 138 ? -15.40218 15.17206  -29.75071 0.983 40.73021 ? 318  ASN A CG   1 
ATOM   1979 O OD1  . ASN A 1 138 ? -15.10072 14.45256  -30.71160 0.983 35.52219 ? 318  ASN A OD1  1 
ATOM   1980 N ND2  . ASN A 1 138 ? -15.28705 16.49869  -29.79044 0.983 46.30797 ? 318  ASN A ND2  1 
ATOM   1981 H H    . ASN A 1 138 ? -16.18386 12.89128  -26.33029 0.983 21.20424 ? 318  ASN A H    1 
ATOM   1982 H HA   . ASN A 1 138 ? -15.78929 12.61152  -28.99884 0.983 25.01109 ? 318  ASN A HA   1 
ATOM   1983 H HB2  . ASN A 1 138 ? -16.95010 14.65251  -28.50954 0.983 27.25287 ? 318  ASN A HB2  1 
ATOM   1984 H HB3  . ASN A 1 138 ? -15.65869 15.13039  -27.71627 0.983 27.25287 ? 318  ASN A HB3  1 
ATOM   1985 H HD21 . ASN A 1 138 ? -15.53194 16.97196  -29.11543 0.983 55.56957 ? 318  ASN A HD21 1 
ATOM   1986 H HD22 . ASN A 1 138 ? -14.96782 16.88181  -30.49109 0.983 55.56957 ? 318  ASN A HD22 1 
ATOM   1987 N N    . GLY A 1 139 ? -13.65532 12.02573  -27.17647 1.000 18.68572 ? 319  GLY A N    1 
ATOM   1988 C CA   . GLY A 1 139 ? -12.23110 11.71913  -27.16295 1.000 17.61445 ? 319  GLY A CA   1 
ATOM   1989 C C    . GLY A 1 139 ? -11.37620 12.56760  -26.24067 1.000 15.95555 ? 319  GLY A C    1 
ATOM   1990 O O    . GLY A 1 139 ? -10.23664 12.87957  -26.59460 1.000 19.87807 ? 319  GLY A O    1 
ATOM   1991 H H    . GLY A 1 139 ? -14.14298 11.53390  -26.66667 1.000 22.42287 ? 319  GLY A H    1 
ATOM   1992 H HA2  . GLY A 1 139 ? -12.11963 10.79410  -26.89314 1.000 21.13733 ? 319  GLY A HA2  1 
ATOM   1993 H HA3  . GLY A 1 139 ? -11.88563 11.82951  -28.06260 1.000 21.13733 ? 319  GLY A HA3  1 
ATOM   1994 N N    . ASP A 1 140 ? -11.87475 12.91861  -25.03874 1.000 16.57870 ? 320  ASP A N    1 
ATOM   1995 C CA   . ASP A 1 140 ? -11.12906 13.83403  -24.18382 1.000 15.78871 ? 320  ASP A CA   1 
ATOM   1996 C C    . ASP A 1 140 ? -10.13536 13.12233  -23.28728 1.000 14.52097 ? 320  ASP A C    1 
ATOM   1997 O O    . ASP A 1 140 ? -9.46648  13.77828  -22.47946 1.000 16.31856 ? 320  ASP A O    1 
ATOM   1998 C CB   . ASP A 1 140 ? -12.04749 14.75801  -23.37122 1.000 15.71450 ? 320  ASP A CB   1 
ATOM   1999 C CG   . ASP A 1 140 ? -12.80717 14.08922  -22.24507 1.000 16.60885 ? 320  ASP A CG   1 
ATOM   2000 O OD1  . ASP A 1 140 ? -12.58835 12.94373  -21.83116 1.000 16.99510 ? 320  ASP A OD1  1 
ATOM   2001 O OD2  . ASP A 1 140 ? -13.64490 14.82819  -21.69139 1.000 23.28418 ? 320  ASP A OD2  1 
ATOM   2002 H H    . ASP A 1 140 ? -12.62210 12.64199  -24.71539 1.000 19.89444 ? 320  ASP A H    1 
ATOM   2003 H HA   . ASP A 1 140 ? -10.62747 14.42662  -24.76532 1.000 18.94645 ? 320  ASP A HA   1 
ATOM   2004 H HB2  . ASP A 1 140 ? -11.50528 15.45931  -22.97740 1.000 18.85739 ? 320  ASP A HB2  1 
ATOM   2005 H HB3  . ASP A 1 140 ? -12.70325 15.14397  -23.97281 1.000 18.85739 ? 320  ASP A HB3  1 
ATOM   2006 N N    . GLY A 1 141 ? -10.01023 11.81493  -23.42021 1.000 14.19914 ? 321  GLY A N    1 
ATOM   2007 C CA   . GLY A 1 141 ? -9.05351  11.05170  -22.65415 1.000 15.28380 ? 321  GLY A CA   1 
ATOM   2008 C C    . GLY A 1 141 ? -9.66218  10.16156  -21.60156 1.000 14.53702 ? 321  GLY A C    1 
ATOM   2009 O O    . GLY A 1 141 ? -9.01509  9.19282   -21.17459 1.000 16.34703 ? 321  GLY A O    1 
ATOM   2010 H H    . GLY A 1 141 ? -10.48098 11.34034  -23.96128 1.000 17.03896 ? 321  GLY A H    1 
ATOM   2011 H HA2  . GLY A 1 141 ? -8.54513  10.49011  -23.26002 1.000 18.34056 ? 321  GLY A HA2  1 
ATOM   2012 H HA3  . GLY A 1 141 ? -8.44820  11.66574  -22.20979 1.000 18.34056 ? 321  GLY A HA3  1 
ATOM   2013 N N    . ARG A 1 142 ? -10.87168 10.46404  -21.14401 1.000 13.34945 ? 322  ARG A N    1 
ATOM   2014 C CA   . ARG A 1 142 ? -11.46318 9.66675   -20.06829 1.000 14.72846 ? 322  ARG A CA   1 
ATOM   2015 C C    . ARG A 1 142 ? -11.86653 8.27217   -20.57825 1.000 13.47152 ? 322  ARG A C    1 
ATOM   2016 O O    . ARG A 1 142 ? -12.61659 8.14915   -21.54974 1.000 15.89831 ? 322  ARG A O    1 
ATOM   2017 C CB   . ARG A 1 142 ? -12.67656 10.40408  -19.48939 1.000 13.93007 ? 322  ARG A CB   1 
ATOM   2018 C CG   . ARG A 1 142 ? -12.33988 11.66506  -18.76557 1.000 15.97691 ? 322  ARG A CG   1 
ATOM   2019 C CD   . ARG A 1 142 ? -13.61370 12.28691  -18.21622 1.000 14.66351 ? 322  ARG A CD   1 
ATOM   2020 N NE   . ARG A 1 142 ? -14.23122 13.21286  -19.16785 1.000 14.67388 ? 322  ARG A NE   1 
ATOM   2021 C CZ   . ARG A 1 142 ? -15.23533 14.02023  -18.84917 1.000 14.67572 ? 322  ARG A CZ   1 
ATOM   2022 N NH1  . ARG A 1 142 ? -15.89071 13.88550  -17.70558 1.000 16.32389 ? 322  ARG A NH1  1 
ATOM   2023 N NH2  . ARG A 1 142 ? -15.57691 14.98123  -19.69076 1.000 14.45267 ? 322  ARG A NH2  1 
ATOM   2024 H H    . ARG A 1 142 ? -11.36180 11.11007  -21.43040 1.000 16.01934 ? 322  ARG A H    1 
ATOM   2025 H HA   . ARG A 1 142 ? -10.81100 9.54035   -19.36148 1.000 17.67415 ? 322  ARG A HA   1 
ATOM   2026 H HB2  . ARG A 1 142 ? -13.27567 10.63368  -20.21689 1.000 16.71609 ? 322  ARG A HB2  1 
ATOM   2027 H HB3  . ARG A 1 142 ? -13.12615 9.81623   -18.86233 1.000 16.71609 ? 322  ARG A HB3  1 
ATOM   2028 H HG2  . ARG A 1 142 ? -11.74162 11.47120  -18.02706 1.000 19.17229 ? 322  ARG A HG2  1 
ATOM   2029 H HG3  . ARG A 1 142 ? -11.92175 12.29313  -19.37517 1.000 19.17229 ? 322  ARG A HG3  1 
ATOM   2030 H HD2  . ARG A 1 142 ? -14.25270 11.58387  -18.02049 1.000 17.59621 ? 322  ARG A HD2  1 
ATOM   2031 H HD3  . ARG A 1 142 ? -13.40450 12.77969  -17.40734 1.000 17.59621 ? 322  ARG A HD3  1 
ATOM   2032 H HE   . ARG A 1 142 ? -13.92849 13.23459  -19.97252 1.000 17.60865 ? 322  ARG A HE   1 
ATOM   2033 H HH11 . ARG A 1 142 ? -15.66800 13.26547  -17.15280 1.000 19.58866 ? 322  ARG A HH11 1 
ATOM   2034 H HH12 . ARG A 1 142 ? -16.53883 14.41807  -17.51607 1.000 19.58866 ? 322  ARG A HH12 1 
ATOM   2035 H HH21 . ARG A 1 142 ? -15.15042 15.07573  -20.43156 1.000 17.34321 ? 322  ARG A HH21 1 
ATOM   2036 H HH22 . ARG A 1 142 ? -16.22554 15.51175  -19.49732 1.000 17.34321 ? 322  ARG A HH22 1 
ATOM   2037 N N    . CYS A 1 143 ? -11.40689 7.22749   -19.91989 1.000 13.25398 ? 323  CYS A N    1 
ATOM   2038 C CA   . CYS A 1 143 ? -11.78120 5.88290   -20.28822 1.000 13.62501 ? 323  CYS A CA   1 
ATOM   2039 C C    . CYS A 1 143 ? -12.57202 5.12690   -19.22701 1.000 14.34004 ? 323  CYS A C    1 
ATOM   2040 O O    . CYS A 1 143 ? -13.40512 4.30806   -19.60311 1.000 14.89151 ? 323  CYS A O    1 
ATOM   2041 C CB   . CYS A 1 143 ? -10.56404 5.05964   -20.77212 1.000 15.87414 ? 323  CYS A CB   1 
ATOM   2042 S SG   . CYS A 1 143 ? -9.31540  4.68679   -19.52351 1.000 17.27519 ? 323  CYS A SG   1 
ATOM   2043 H H    . CYS A 1 143 ? -10.87094 7.27404   -19.24893 1.000 15.90477 ? 323  CYS A H    1 
ATOM   2044 H HA   . CYS A 1 143 ? -12.36886 5.94019   -21.05781 1.000 16.35001 ? 323  CYS A HA   1 
ATOM   2045 H HB2  . CYS A 1 143 ? -10.88835 4.21231   -21.11529 1.000 19.04897 ? 323  CYS A HB2  1 
ATOM   2046 H HB3  . CYS A 1 143 ? -10.12336 5.55696   -21.47878 1.000 19.04897 ? 323  CYS A HB3  1 
ATOM   2047 H HG   . CYS A 1 143 ? -8.48197  3.97086   -20.00605 1.000 20.73022 ? 323  CYS A HG   1 
ATOM   2048 N N    . VAL A 1 144 ? -12.37078 5.39973   -17.94767 1.000 13.63851 ? 324  VAL A N    1 
ATOM   2049 C CA   . VAL A 1 144 ? -13.11365 4.74352   -16.86882 1.000 12.82200 ? 324  VAL A CA   1 
ATOM   2050 C C    . VAL A 1 144 ? -13.63121 5.78639   -15.90944 1.000 13.30035 ? 324  VAL A C    1 
ATOM   2051 O O    . VAL A 1 144 ? -12.86358 6.61071   -15.40244 1.000 14.17867 ? 324  VAL A O    1 
ATOM   2052 C CB   . VAL A 1 144 ? -12.22219 3.73981   -16.10940 1.000 11.82831 ? 324  VAL A CB   1 
ATOM   2053 C CG1  . VAL A 1 144 ? -12.94647 3.18284   -14.87998 1.000 15.79074 ? 324  VAL A CG1  1 
ATOM   2054 C CG2  . VAL A 1 144 ? -11.71746 2.62863   -16.97231 1.000 14.93447 ? 324  VAL A CG2  1 
ATOM   2055 H H    . VAL A 1 144 ? -11.79620 5.97473   -17.66690 1.000 16.36622 ? 324  VAL A H    1 
ATOM   2056 H HA   . VAL A 1 144 ? -13.87571 4.28163   -17.25199 1.000 15.38640 ? 324  VAL A HA   1 
ATOM   2057 H HB   . VAL A 1 144 ? -11.44035 4.23244   -15.81454 1.000 14.19397 ? 324  VAL A HB   1 
ATOM   2058 H HG11 . VAL A 1 144 ? -12.47563 2.39502   -14.56605 1.000 18.94889 ? 324  VAL A HG11 1 
ATOM   2059 H HG12 . VAL A 1 144 ? -12.95711 3.86033   -14.18586 1.000 18.94889 ? 324  VAL A HG12 1 
ATOM   2060 H HG13 . VAL A 1 144 ? -13.85463 2.94869   -15.12761 1.000 18.94889 ? 324  VAL A HG13 1 
ATOM   2061 H HG21 . VAL A 1 144 ? -11.14653 2.05117   -16.44177 1.000 17.92137 ? 324  VAL A HG21 1 
ATOM   2062 H HG22 . VAL A 1 144 ? -12.47326 2.12460   -17.31235 1.000 17.92137 ? 324  VAL A HG22 1 
ATOM   2063 H HG23 . VAL A 1 144 ? -11.21269 3.00581   -17.70976 1.000 17.92137 ? 324  VAL A HG23 1 
ATOM   2064 N N    . THR A 1 145 ? -14.93490 5.75185   -15.62956 1.000 12.84592 ? 325  THR A N    1 
ATOM   2065 C CA   . THR A 1 145 ? -15.54509 6.56149   -14.58885 1.000 11.62395 ? 325  THR A CA   1 
ATOM   2066 C C    . THR A 1 145 ? -15.62118 5.69618   -13.33509 1.000 11.44778 ? 325  THR A C    1 
ATOM   2067 O O    . THR A 1 145 ? -16.02211 4.53738   -13.39641 1.000 14.99028 ? 325  THR A O    1 
ATOM   2068 C CB   . THR A 1 145 ? -16.96493 6.88091   -15.02676 1.000 12.13285 ? 325  THR A CB   1 
ATOM   2069 O OG1  . THR A 1 145 ? -16.92545 7.56408   -16.29682 1.000 14.21293 ? 325  THR A OG1  1 
ATOM   2070 C CG2  . THR A 1 145 ? -17.64779 7.76516   -13.99434 1.000 14.85500 ? 325  THR A CG2  1 
ATOM   2071 H H    . THR A 1 145 ? -15.49858 5.25132   -16.04348 1.000 15.41510 ? 325  THR A H    1 
ATOM   2072 H HA   . THR A 1 145 ? -15.04616 7.37500   -14.41513 1.000 13.94875 ? 325  THR A HA   1 
ATOM   2073 H HB   . THR A 1 145 ? -17.47804 6.06239   -15.11419 1.000 14.55941 ? 325  THR A HB   1 
ATOM   2074 H HG1  . THR A 1 145 ? -17.10393 8.37803   -16.19088 1.000 17.05552 ? 325  THR A HG1  1 
ATOM   2075 H HG21 . THR A 1 145 ? -18.46729 8.13183   -14.36159 1.000 17.82600 ? 325  THR A HG21 1 
ATOM   2076 H HG22 . THR A 1 145 ? -17.86182 7.24665   -13.20298 1.000 17.82600 ? 325  THR A HG22 1 
ATOM   2077 H HG23 . THR A 1 145 ? -17.06105 8.49552   -13.74296 1.000 17.82600 ? 325  THR A HG23 1 
ATOM   2078 N N    . CYS A 1 146 ? -15.21785 6.28087   -12.19961 1.000 12.87509 ? 326  CYS A N    1 
ATOM   2079 C CA   . CYS A 1 146 ? -15.26255 5.56923   -10.92224 1.000 13.94328 ? 326  CYS A CA   1 
ATOM   2080 C C    . CYS A 1 146 ? -16.01741 6.47201   -9.94517  1.000 12.87779 ? 326  CYS A C    1 
ATOM   2081 O O    . CYS A 1 146 ? -15.64386 7.63112   -9.74509  1.000 15.15553 ? 326  CYS A O    1 
ATOM   2082 C CB   . CYS A 1 146 ? -13.83438 5.35997   -10.42921 1.000 15.60358 ? 326  CYS A CB   1 
ATOM   2083 S SG   . CYS A 1 146 ? -13.69723 4.50252   -8.87682  1.000 17.84827 ? 326  CYS A SG   1 
ATOM   2084 H H    . CYS A 1 146 ? -14.91659 7.08471   -12.14784 1.000 15.45011 ? 326  CYS A H    1 
ATOM   2085 H HA   . CYS A 1 146 ? -15.71245 4.71249   -10.98919 1.000 16.73193 ? 326  CYS A HA   1 
ATOM   2086 H HB2  . CYS A 1 146 ? -13.35316 4.84089   -11.09245 1.000 18.72430 ? 326  CYS A HB2  1 
ATOM   2087 H HB3  . CYS A 1 146 ? -13.41635 6.22849   -10.32043 1.000 18.72430 ? 326  CYS A HB3  1 
ATOM   2088 H HG   . CYS A 1 146 ? -14.21227 3.42355   -8.97963  1.000 21.41792 ? 326  CYS A HG   1 
ATOM   2089 N N    . ILE A 1 147 ? -17.04424 5.92409   -9.31981  1.000 14.20103 ? 327  ILE A N    1 
ATOM   2090 C CA   . ILE A 1 147 ? -17.92443 6.69730   -8.44602  1.000 14.07171 ? 327  ILE A CA   1 
ATOM   2091 C C    . ILE A 1 147 ? -18.08374 5.96292   -7.13178  1.000 13.24813 ? 327  ILE A C    1 
ATOM   2092 O O    . ILE A 1 147 ? -18.34651 4.76800   -7.11912  1.000 15.44445 ? 327  ILE A O    1 
ATOM   2093 C CB   . ILE A 1 147 ? -19.32584 6.92426   -9.05191  1.000 13.25638 ? 327  ILE A CB   1 
ATOM   2094 C CG1  . ILE A 1 147 ? -19.20502 7.47227   -10.48200 1.000 14.72584 ? 327  ILE A CG1  1 
ATOM   2095 C CG2  . ILE A 1 147 ? -20.15630 7.90389   -8.20231  1.000 13.67184 ? 327  ILE A CG2  1 
ATOM   2096 C CD1  . ILE A 1 147 ? -20.57296 7.80830   -11.11707 1.000 16.06840 ? 327  ILE A CD1  1 
ATOM   2097 H H    . ILE A 1 147 ? -17.25890 5.09376   -9.38358  1.000 17.04124 ? 327  ILE A H    1 
ATOM   2098 H HA   . ILE A 1 147 ? -17.50137 7.55741   -8.29727  1.000 16.88606 ? 327  ILE A HA   1 
ATOM   2099 H HB   . ILE A 1 147 ? -19.77646 6.06539   -9.06517  1.000 15.90765 ? 327  ILE A HB   1 
ATOM   2100 H HG12 . ILE A 1 147 ? -18.67562 8.28487   -10.46410 1.000 17.67101 ? 327  ILE A HG12 1 
ATOM   2101 H HG13 . ILE A 1 147 ? -18.77200 6.80640   -11.03879 1.000 17.67101 ? 327  ILE A HG13 1 
ATOM   2102 H HG21 . ILE A 1 147 ? -21.07476 7.89206   -8.51406  1.000 16.40620 ? 327  ILE A HG21 1 
ATOM   2103 H HG22 . ILE A 1 147 ? -20.11865 7.62670   -7.27352  1.000 16.40620 ? 327  ILE A HG22 1 
ATOM   2104 H HG23 . ILE A 1 147 ? -19.78643 8.79563   -8.29662  1.000 16.40620 ? 327  ILE A HG23 1 
ATOM   2105 H HD11 . ILE A 1 147 ? -20.45257 7.95179   -12.06881 1.000 19.28208 ? 327  ILE A HD11 1 
ATOM   2106 H HD12 . ILE A 1 147 ? -21.18070 7.06701   -10.96858 1.000 19.28208 ? 327  ILE A HD12 1 
ATOM   2107 H HD13 . ILE A 1 147 ? -20.92435 8.61213   -10.70320 1.000 19.28208 ? 327  ILE A HD13 1 
ATOM   2108 N N    . TYR A 1 148 ? -17.98737 6.68791   -6.02940  1.000 13.01572 ? 328  TYR A N    1 
ATOM   2109 C CA   . TYR A 1 148 ? -18.25437 6.16741   -4.69197  1.000 14.35192 ? 328  TYR A CA   1 
ATOM   2110 C C    . TYR A 1 148 ? -19.49462 6.86459   -4.15842  1.000 15.04285 ? 328  TYR A C    1 
ATOM   2111 O O    . TYR A 1 148 ? -19.57080 8.08929   -4.17197  1.000 15.53243 ? 328  TYR A O    1 
ATOM   2112 C CB   . TYR A 1 148 ? -17.04688 6.45067   -3.80443  1.000 13.37868 ? 328  TYR A CB   1 
ATOM   2113 C CG   . TYR A 1 148 ? -17.19403 5.94064   -2.40803  1.000 16.19983 ? 328  TYR A CG   1 
ATOM   2114 C CD1  . TYR A 1 148 ? -17.08095 4.56397   -2.11386  1.000 15.88827 ? 328  TYR A CD1  1 
ATOM   2115 C CD2  . TYR A 1 148 ? -17.45947 6.78411   -1.33297  1.000 17.27371 ? 328  TYR A CD2  1 
ATOM   2116 C CE1  . TYR A 1 148 ? -17.23874 4.08416   -0.84681  1.000 16.89728 ? 328  TYR A CE1  1 
ATOM   2117 C CE2  . TYR A 1 148 ? -17.61216 6.30932   -0.05918  1.000 18.29806 ? 328  TYR A CE2  1 
ATOM   2118 C CZ   . TYR A 1 148 ? -17.46014 4.94510   0.22810   1.000 18.20524 ? 328  TYR A CZ   1 
ATOM   2119 O OH   . TYR A 1 148 ? -17.61731 4.48364   1.50141   1.000 20.01938 ? 328  TYR A OH   1 
ATOM   2120 H H    . TYR A 1 148 ? -17.76016 7.51734   -6.02694  1.000 15.61887 ? 328  TYR A H    1 
ATOM   2121 H HA   . TYR A 1 148 ? -18.42185 5.21200   -4.69839  1.000 17.22230 ? 328  TYR A HA   1 
ATOM   2122 H HB2  . TYR A 1 148 ? -16.26677 6.02590   -4.19420  1.000 16.05442 ? 328  TYR A HB2  1 
ATOM   2123 H HB3  . TYR A 1 148 ? -16.91308 7.41021   -3.75669  1.000 16.05442 ? 328  TYR A HB3  1 
ATOM   2124 H HD1  . TYR A 1 148 ? -16.89376 3.96818   -2.80298  1.000 19.06593 ? 328  TYR A HD1  1 
ATOM   2125 H HD2  . TYR A 1 148 ? -17.53533 7.69840   -1.48537  1.000 20.72845 ? 328  TYR A HD2  1 
ATOM   2126 H HE1  . TYR A 1 148 ? -17.19802 3.16721   -0.69701  1.000 20.27674 ? 328  TYR A HE1  1 
ATOM   2127 H HE2  . TYR A 1 148 ? -17.82019 6.90092   0.62757   1.000 21.95767 ? 328  TYR A HE2  1 
ATOM   2128 H HH   . TYR A 1 148 ? -17.50024 3.65209   1.52214   1.000 24.02325 ? 328  TYR A HH   1 
ATOM   2129 N N    . TYR A 1 149 ? -20.44568 6.09161   -3.66387  1.000 15.29299 ? 329  TYR A N    1 
ATOM   2130 C CA   . TYR A 1 149 ? -21.66175 6.64404   -3.08942  1.000 14.69352 ? 329  TYR A CA   1 
ATOM   2131 C C    . TYR A 1 149 ? -21.62250 6.54092   -1.57945  1.000 16.50482 ? 329  TYR A C    1 
ATOM   2132 O O    . TYR A 1 149 ? -21.05407 5.60909   -1.01088  1.000 18.81586 ? 329  TYR A O    1 
ATOM   2133 C CB   . TYR A 1 149 ? -22.85548 5.87865   -3.62383  1.000 16.13631 ? 329  TYR A CB   1 
ATOM   2134 C CG   . TYR A 1 149 ? -23.01517 6.01211   -5.11803  1.000 15.11645 ? 329  TYR A CG   1 
ATOM   2135 C CD1  . TYR A 1 149 ? -23.49889 7.17830   -5.67577  1.000 14.03289 ? 329  TYR A CD1  1 
ATOM   2136 C CD2  . TYR A 1 149 ? -22.70109 4.95938   -5.95137  1.000 16.35770 ? 329  TYR A CD2  1 
ATOM   2137 C CE1  . TYR A 1 149 ? -23.67929 7.29878   -7.03728  1.000 16.70177 ? 329  TYR A CE1  1 
ATOM   2138 C CE2  . TYR A 1 149 ? -22.87591 5.05669   -7.31352  1.000 15.43511 ? 329  TYR A CE2  1 
ATOM   2139 C CZ   . TYR A 1 149 ? -23.34078 6.22291   -7.85621  1.000 17.12467 ? 329  TYR A CZ   1 
ATOM   2140 O OH   . TYR A 1 149 ? -23.48480 6.25659   -9.22361  1.000 17.89078 ? 329  TYR A OH   1 
ATOM   2141 H H    . TYR A 1 149 ? -20.41007 5.23248   -3.64900  1.000 18.35159 ? 329  TYR A H    1 
ATOM   2142 H HA   . TYR A 1 149 ? -21.74960 7.58320   -3.31562  1.000 17.63223 ? 329  TYR A HA   1 
ATOM   2143 H HB2  . TYR A 1 149 ? -22.74513 4.93746   -3.41676  1.000 19.36357 ? 329  TYR A HB2  1 
ATOM   2144 H HB3  . TYR A 1 149 ? -23.66146 6.21834   -3.20443  1.000 19.36357 ? 329  TYR A HB3  1 
ATOM   2145 H HD1  . TYR A 1 149 ? -23.70707 7.89640   -5.12269  1.000 16.83947 ? 329  TYR A HD1  1 
ATOM   2146 H HD2  . TYR A 1 149 ? -22.36608 4.17168   -5.58778  1.000 19.62923 ? 329  TYR A HD2  1 
ATOM   2147 H HE1  . TYR A 1 149 ? -24.02042 8.08314   -7.40240  1.000 20.04213 ? 329  TYR A HE1  1 
ATOM   2148 H HE2  . TYR A 1 149 ? -22.67869 4.33234   -7.86244  1.000 18.52213 ? 329  TYR A HE2  1 
ATOM   2149 H HH   . TYR A 1 149 ? -23.79863 6.99863   -9.46126  1.000 21.46894 ? 329  TYR A HH   1 
ATOM   2150 N N    . LEU A 1 150 ? -22.27266 7.50974   -0.91680  1.000 16.91973 ? 330  LEU A N    1 
ATOM   2151 C CA   . LEU A 1 150 ? -22.12182 7.64604   0.52333   1.000 18.19475 ? 330  LEU A CA   1 
ATOM   2152 C C    . LEU A 1 150 ? -23.41402 7.99973   1.25213   1.000 17.00069 ? 330  LEU A C    1 
ATOM   2153 O O    . LEU A 1 150 ? -23.37936 8.61823   2.32247   1.000 21.35243 ? 330  LEU A O    1 
ATOM   2154 C CB   . LEU A 1 150 ? -21.01429 8.64101   0.87122   1.000 21.70071 ? 330  LEU A CB   1 
ATOM   2155 C CG   . LEU A 1 150 ? -21.24195 9.99215   0.20535   1.000 18.02755 ? 330  LEU A CG   1 
ATOM   2156 C CD1  . LEU A 1 150 ? -20.94473 11.04768  1.20827   1.000 21.47469 ? 330  LEU A CD1  1 
ATOM   2157 C CD2  . LEU A 1 150 ? -20.25570 10.17000  -0.97720  1.000 19.18597 ? 330  LEU A CD2  1 
ATOM   2158 H H    . LEU A 1 150 ? -22.79636 8.08680   -1.28059  1.000 20.30368 ? 330  LEU A H    1 
ATOM   2159 H HA   . LEU A 1 150 ? -21.86758 6.77342   0.86215   1.000 21.83370 ? 330  LEU A HA   1 
ATOM   2160 H HB2  . LEU A 1 150 ? -20.99431 8.77335   1.83194   1.000 26.04085 ? 330  LEU A HB2  1 
ATOM   2161 H HB3  . LEU A 1 150 ? -20.16276 8.29003   0.56690   1.000 26.04085 ? 330  LEU A HB3  1 
ATOM   2162 H HG   . LEU A 1 150 ? -22.15308 10.05759  -0.12093  1.000 21.63306 ? 330  LEU A HG   1 
ATOM   2163 H HD11 . LEU A 1 150 ? -21.06957 11.91758  0.79767   1.000 25.76962 ? 330  LEU A HD11 1 
ATOM   2164 H HD12 . LEU A 1 150 ? -21.54857 10.94736  1.96074   1.000 25.76962 ? 330  LEU A HD12 1 
ATOM   2165 H HD13 . LEU A 1 150 ? -20.02656 10.95105  1.50580   1.000 25.76962 ? 330  LEU A HD13 1 
ATOM   2166 H HD21 . LEU A 1 150 ? -20.38186 11.05059  -1.36392  1.000 23.02316 ? 330  LEU A HD21 1 
ATOM   2167 H HD22 . LEU A 1 150 ? -19.34787 10.08050  -0.64747  1.000 23.02316 ? 330  LEU A HD22 1 
ATOM   2168 H HD23 . LEU A 1 150 ? -20.43460 9.48762   -1.64297  1.000 23.02316 ? 330  LEU A HD23 1 
ATOM   2169 N N    . ASN A 1 151 ? -24.54703 7.53334   0.75392   1.000 18.56959 ? 331  ASN A N    1 
ATOM   2170 C CA   . ASN A 1 151 ? -25.85752 7.93135   1.26139   1.000 18.52579 ? 331  ASN A CA   1 
ATOM   2171 C C    . ASN A 1 151 ? -26.38131 6.84938   2.20932   1.000 18.97642 ? 331  ASN A C    1 
ATOM   2172 O O    . ASN A 1 151 ? -27.05546 5.88967   1.79853   1.000 22.61684 ? 331  ASN A O    1 
ATOM   2173 C CB   . ASN A 1 151 ? -26.75028 8.17922   0.04696   1.000 16.29322 ? 331  ASN A CB   1 
ATOM   2174 C CG   . ASN A 1 151 ? -26.14251 9.15193   -0.89456  1.000 15.78235 ? 331  ASN A CG   1 
ATOM   2175 O OD1  . ASN A 1 151 ? -26.00343 10.33308  -0.54074  1.000 18.37000 ? 331  ASN A OD1  1 
ATOM   2176 N ND2  . ASN A 1 151 ? -25.70016 8.67670   -2.03111  1.000 16.01450 ? 331  ASN A ND2  1 
ATOM   2177 H H    . ASN A 1 151 ? -24.58783 6.97061   0.10487   1.000 22.28351 ? 331  ASN A H    1 
ATOM   2178 H HA   . ASN A 1 151 ? -25.80562 8.73256   1.80571   1.000 22.23094 ? 331  ASN A HA   1 
ATOM   2179 H HB2  . ASN A 1 151 ? -26.88657 7.34319   -0.42567  1.000 19.55186 ? 331  ASN A HB2  1 
ATOM   2180 H HB3  . ASN A 1 151 ? -27.60236 8.53523   0.34382   1.000 19.55186 ? 331  ASN A HB3  1 
ATOM   2181 H HD21 . ASN A 1 151 ? -25.76937 7.83670   -2.20202  1.000 19.21741 ? 331  ASN A HD21 1 
ATOM   2182 H HD22 . ASN A 1 151 ? -25.34031 9.20445   -2.60694  1.000 19.21741 ? 331  ASN A HD22 1 
ATOM   2183 N N    . LYS A 1 152 ? -26.06556 7.02266   3.49802   1.000 20.95084 ? 332  LYS A N    1 
ATOM   2184 C CA   . LYS A 1 152 ? -26.56169 6.13069   4.51780   1.000 21.56288 ? 332  LYS A CA   1 
ATOM   2185 C C    . LYS A 1 152 ? -28.06071 6.42550   4.56615   1.000 30.37969 ? 332  LYS A C    1 
ATOM   2186 O O    . LYS A 1 152 ? -28.47111 7.58757   4.43528   1.000 45.87327 ? 332  LYS A O    1 
ATOM   2187 C CB   . LYS A 1 152 ? -25.93122 6.51111   5.86794   1.000 24.50453 ? 332  LYS A CB   1 
ATOM   2188 C CG   . LYS A 1 152 ? -25.92683 5.38230   6.90168   1.000 28.27107 ? 332  LYS A CG   1 
ATOM   2189 H H    . LYS A 1 152 ? -25.56379 7.65410   3.79653   1.000 25.14101 ? 332  LYS A H    1 
ATOM   2190 H HA   . LYS A 1 152 ? -26.36608 5.19508   4.35271   1.000 25.87546 ? 332  LYS A HA   1 
ATOM   2191 H HB2  . LYS A 1 152 ? -25.00998 6.77422   5.71633   1.000 29.40543 ? 332  LYS A HB2  1 
ATOM   2192 H HB3  . LYS A 1 152 ? -26.43030 7.25262   6.24477   1.000 29.40543 ? 332  LYS A HB3  1 
ATOM   2193 N N    . ASP A 1 153 ? -28.87239 5.41029   4.65460   1.000 44.27000 ? 333  ASP A N    1 
ATOM   2194 C CA   . ASP A 1 153 ? -30.31911 5.59073   4.72348   1.000 29.15118 ? 333  ASP A CA   1 
ATOM   2195 C C    . ASP A 1 153 ? -31.03040 5.87815   3.40556   1.000 23.15395 ? 333  ASP A C    1 
ATOM   2196 O O    . ASP A 1 153 ? -32.26061 6.05137   3.45861   1.000 26.10508 ? 333  ASP A O    1 
ATOM   2197 C CB   . ASP A 1 153 ? -30.79911 6.64659   5.73858   1.000 32.10367 ? 333  ASP A CB   1 
ATOM   2198 C CG   . ASP A 1 153 ? -30.00544 6.65645   7.01869   1.000 53.75312 ? 333  ASP A CG   1 
ATOM   2199 O OD1  . ASP A 1 153 ? -29.61715 7.75758   7.46299   1.000 61.61315 ? 333  ASP A OD1  1 
ATOM   2200 O OD2  . ASP A 1 153 ? -29.78253 5.56011   7.57852   1.000 44.61717 ? 333  ASP A OD2  1 
ATOM   2201 H H    . ASP A 1 153 ? -28.61446 4.59020   4.67747   1.000 53.12400 ? 333  ASP A H    1 
ATOM   2202 H HA   . ASP A 1 153 ? -30.62544 4.71649   5.01119   1.000 34.98142 ? 333  ASP A HA   1 
ATOM   2203 H HB2  . ASP A 1 153 ? -30.72257 7.52559   5.33559   1.000 38.52440 ? 333  ASP A HB2  1 
ATOM   2204 H HB3  . ASP A 1 153 ? -31.72464 6.46489   5.96504   1.000 38.52440 ? 333  ASP A HB3  1 
ATOM   2205 N N    . TRP A 1 154 ? -30.37685 5.90455   2.26673   1.000 21.01886 ? 334  TRP A N    1 
ATOM   2206 C CA   . TRP A 1 154 ? -31.07037 6.13025   1.00825   1.000 19.19487 ? 334  TRP A CA   1 
ATOM   2207 C C    . TRP A 1 154 ? -32.07422 5.02409   0.72362   1.000 21.70075 ? 334  TRP A C    1 
ATOM   2208 O O    . TRP A 1 154 ? -31.73068 3.83816   0.73267   1.000 23.35366 ? 334  TRP A O    1 
ATOM   2209 C CB   . TRP A 1 154 ? -30.06349 6.18401   -0.13317  1.000 19.96111 ? 334  TRP A CB   1 
ATOM   2210 C CG   . TRP A 1 154 ? -30.61835 6.78916   -1.37436  1.000 18.28164 ? 334  TRP A CG   1 
ATOM   2211 C CD1  . TRP A 1 154 ? -31.11463 6.14820   -2.46660  1.000 18.86598 ? 334  TRP A CD1  1 
ATOM   2212 C CD2  . TRP A 1 154 ? -30.77048 8.18242   -1.62422  1.000 17.93438 ? 334  TRP A CD2  1 
ATOM   2213 N NE1  . TRP A 1 154 ? -31.54100 7.06200   -3.40655  1.000 19.25352 ? 334  TRP A NE1  1 
ATOM   2214 C CE2  . TRP A 1 154 ? -31.34016 8.31865   -2.90419  1.000 20.25050 ? 334  TRP A CE2  1 
ATOM   2215 C CE3  . TRP A 1 154 ? -30.47580 9.33501   -0.87791  1.000 18.07696 ? 334  TRP A CE3  1 
ATOM   2216 C CZ2  . TRP A 1 154 ? -31.61908 9.56482   -3.46534  1.000 18.01393 ? 334  TRP A CZ2  1 
ATOM   2217 C CZ3  . TRP A 1 154 ? -30.74608 10.56540  -1.44236  1.000 19.33849 ? 334  TRP A CZ3  1 
ATOM   2218 C CH2  . TRP A 1 154 ? -31.32141 10.66589  -2.71284  1.000 19.70099 ? 334  TRP A CH2  1 
ATOM   2219 H H    . TRP A 1 154 ? -29.52754 5.79477   2.18784   1.000 25.22263 ? 334  TRP A H    1 
ATOM   2220 H HA   . TRP A 1 154 ? -31.54604 6.97354   1.06746   1.000 23.03384 ? 334  TRP A HA   1 
ATOM   2221 H HB2  . TRP A 1 154 ? -29.30197 6.71693   0.14428   1.000 23.95333 ? 334  TRP A HB2  1 
ATOM   2222 H HB3  . TRP A 1 154 ? -29.77776 5.28112   -0.34306  1.000 23.95333 ? 334  TRP A HB3  1 
ATOM   2223 H HD1  . TRP A 1 154 ? -31.15987 5.22456   -2.56527  1.000 22.63917 ? 334  TRP A HD1  1 
ATOM   2224 H HE1  . TRP A 1 154 ? -31.87565 6.87445   -4.17625  1.000 23.10423 ? 334  TRP A HE1  1 
ATOM   2225 H HE3  . TRP A 1 154 ? -30.10831 9.27103   -0.02600  1.000 21.69235 ? 334  TRP A HE3  1 
ATOM   2226 H HZ2  . TRP A 1 154 ? -31.99116 9.64285   -4.31408  1.000 21.61672 ? 334  TRP A HZ2  1 
ATOM   2227 H HZ3  . TRP A 1 154 ? -30.54219 11.34010  -0.96995  1.000 23.20618 ? 334  TRP A HZ3  1 
ATOM   2228 H HH2  . TRP A 1 154 ? -31.50755 11.50962  -3.05690  1.000 23.64119 ? 334  TRP A HH2  1 
ATOM   2229 N N    . ASP A 1 155 ? -33.31204 5.42007   0.43855   1.000 21.72587 ? 335  ASP A N    1 
ATOM   2230 C CA   . ASP A 1 155 ? -34.36937 4.51992   -0.01282  1.000 24.86750 ? 335  ASP A CA   1 
ATOM   2231 C C    . ASP A 1 155 ? -34.77359 4.99751   -1.40251  1.000 23.64079 ? 335  ASP A C    1 
ATOM   2232 O O    . ASP A 1 155 ? -35.56686 5.94356   -1.53863  1.000 23.32673 ? 335  ASP A O    1 
ATOM   2233 C CB   . ASP A 1 155 ? -35.53961 4.53836   0.96770   1.000 23.10051 ? 335  ASP A CB   1 
ATOM   2234 C CG   . ASP A 1 155 ? -36.66827 3.63863   0.53988   1.000 24.05526 ? 335  ASP A CG   1 
ATOM   2235 O OD1  . ASP A 1 155 ? -36.51806 2.95037   -0.49881  1.000 26.94824 ? 335  ASP A OD1  1 
ATOM   2236 O OD2  . ASP A 1 155 ? -37.68538 3.61772   1.22496   1.000 24.69657 ? 335  ASP A OD2  1 
ATOM   2237 H H    . ASP A 1 155 ? -33.57295 6.23711   0.50159   1.000 26.07104 ? 335  ASP A H    1 
ATOM   2238 H HA   . ASP A 1 155 ? -34.04905 3.60646   -0.07519  1.000 29.84100 ? 335  ASP A HA   1 
ATOM   2239 H HB2  . ASP A 1 155 ? -35.22937 4.23875   1.83654   1.000 27.72062 ? 335  ASP A HB2  1 
ATOM   2240 H HB3  . ASP A 1 155 ? -35.88428 5.44276   1.03226   1.000 27.72062 ? 335  ASP A HB3  1 
ATOM   2241 N N    . ALA A 1 156 ? -34.20659 4.37176   -2.44757  1.000 22.33252 ? 336  ALA A N    1 
ATOM   2242 C CA   . ALA A 1 156 ? -34.40231 4.87534   -3.80187  1.000 22.55631 ? 336  ALA A CA   1 
ATOM   2243 C C    . ALA A 1 156 ? -35.85330 4.81327   -4.24620  1.000 24.22925 ? 336  ALA A C    1 
ATOM   2244 O O    . ALA A 1 156 ? -36.26971 5.56239   -5.13978  1.000 23.83682 ? 336  ALA A O    1 
ATOM   2245 C CB   . ALA A 1 156 ? -33.53768 4.10387   -4.79954  1.000 26.02760 ? 336  ALA A CB   1 
ATOM   2246 H H    . ALA A 1 156 ? -33.71496 3.66821   -2.39360  1.000 26.79902 ? 336  ALA A H    1 
ATOM   2247 H HA   . ALA A 1 156 ? -34.12352 5.80441   -3.80269  1.000 27.06758 ? 336  ALA A HA   1 
ATOM   2248 H HB1  . ALA A 1 156 ? -33.67988 4.46709   -5.68766  1.000 31.23312 ? 336  ALA A HB1  1 
ATOM   2249 H HB2  . ALA A 1 156 ? -32.60544 4.19853   -4.54882  1.000 31.23312 ? 336  ALA A HB2  1 
ATOM   2250 H HB3  . ALA A 1 156 ? -33.79201 3.16801   -4.78029  1.000 31.23312 ? 336  ALA A HB3  1 
ATOM   2251 N N    . LYS A 1 157 ? -36.64075 3.90001   -3.68282  1.000 21.75568 ? 337  LYS A N    1 
ATOM   2252 C CA   . LYS A 1 157 ? -38.03992 3.82719   -4.09917  1.000 22.10170 ? 337  LYS A CA   1 
ATOM   2253 C C    . LYS A 1 157 ? -38.79062 5.10162   -3.71983  1.000 27.54442 ? 337  LYS A C    1 
ATOM   2254 O O    . LYS A 1 157 ? -39.77371 5.46085   -4.37773  1.000 33.77242 ? 337  LYS A O    1 
ATOM   2255 C CB   . LYS A 1 157 ? -38.72636 2.60458   -3.49075  1.000 25.84889 ? 337  LYS A CB   1 
ATOM   2256 C CG   . LYS A 1 157 ? -38.56319 1.32131   -4.30921  1.000 38.32318 ? 337  LYS A CG   1 
ATOM   2257 C CD   . LYS A 1 157 ? -39.50550 1.27620   -5.51514  1.000 45.05641 ? 337  LYS A CD   1 
ATOM   2258 H H    . LYS A 1 157 ? -36.40087 3.33347   -3.08191  1.000 26.10681 ? 337  LYS A H    1 
ATOM   2259 H HA   . LYS A 1 157 ? -38.07158 3.72331   -5.06308  1.000 26.52203 ? 337  LYS A HA   1 
ATOM   2260 H HB2  . LYS A 1 157 ? -38.34959 2.44285   -2.61167  1.000 31.01867 ? 337  LYS A HB2  1 
ATOM   2261 H HB3  . LYS A 1 157 ? -39.67608 2.78727   -3.41616  1.000 31.01867 ? 337  LYS A HB3  1 
ATOM   2262 H HG2  . LYS A 1 157 ? -37.65182 1.26671   -4.63680  1.000 45.98781 ? 337  LYS A HG2  1 
ATOM   2263 H HG3  . LYS A 1 157 ? -38.75924 0.55707   -3.74493  1.000 45.98781 ? 337  LYS A HG3  1 
ATOM   2264 N N    A VAL A 1 158 ? -38.33508 5.79221   -2.68058  0.676 25.18999 ? 338  VAL A N    1 
ATOM   2265 N N    B VAL A 1 158 ? -38.34193 5.79792   -2.67998  0.324 25.16628 ? 338  VAL A N    1 
ATOM   2266 C CA   A VAL A 1 158 ? -38.93551 7.04503   -2.23308  0.676 28.14651 ? 338  VAL A CA   1 
ATOM   2267 C CA   B VAL A 1 158 ? -38.95965 7.04660   -2.25210  0.324 28.08167 ? 338  VAL A CA   1 
ATOM   2268 C C    A VAL A 1 158 ? -38.16455 8.23877   -2.76245  0.676 26.68818 ? 338  VAL A C    1 
ATOM   2269 C C    B VAL A 1 158 ? -38.16935 8.25660   -2.72865  0.324 26.65651 ? 338  VAL A C    1 
ATOM   2270 O O    A VAL A 1 158 ? -38.74588 9.20483   -3.25461  0.676 28.77561 ? 338  VAL A O    1 
ATOM   2271 O O    B VAL A 1 158 ? -38.75082 9.25820   -3.14431  0.324 28.61269 ? 338  VAL A O    1 
ATOM   2272 C CB   A VAL A 1 158 ? -38.98749 7.08393   -0.68946  0.676 24.92154 ? 338  VAL A CB   1 
ATOM   2273 C CB   B VAL A 1 158 ? -39.12097 7.07129   -0.71743  0.324 25.32236 ? 338  VAL A CB   1 
ATOM   2274 H H    A VAL A 1 158 ? -37.66083 5.54933   -2.20518  0.676 30.22799 ? 338  VAL A H    1 
ATOM   2275 H H    B VAL A 1 158 ? -37.66926 5.56282   -2.19848  0.324 30.19954 ? 338  VAL A H    1 
ATOM   2276 H HA   A VAL A 1 158 ? -39.84251 7.08948   -2.57407  0.676 33.77581 ? 338  VAL A HA   1 
ATOM   2277 H HA   B VAL A 1 158 ? -39.84397 7.09636   -2.64758  0.324 33.69800 ? 338  VAL A HA   1 
ATOM   2278 N N    . SER A 1 159 ? -36.84537 8.19477   -2.65373  1.000 22.35348 ? 339  SER A N    1 
ATOM   2279 C CA   . SER A 1 159 ? -36.01938 9.36805   -2.90243  1.000 23.38508 ? 339  SER A CA   1 
ATOM   2280 C C    . SER A 1 159 ? -35.43374 9.42616   -4.29421  1.000 21.77425 ? 339  SER A C    1 
ATOM   2281 O O    . SER A 1 159 ? -34.81337 10.43657  -4.63230  1.000 21.80894 ? 339  SER A O    1 
ATOM   2282 C CB   . SER A 1 159 ? -34.91086 9.42885   -1.86989  1.000 22.67048 ? 339  SER A CB   1 
ATOM   2283 O OG   . SER A 1 159 ? -35.47664 9.59280   -0.59253  1.000 24.49111 ? 339  SER A OG   1 
ATOM   2284 H H    . SER A 1 159 ? -36.39936 7.49255   -2.43565  1.000 26.82418 ? 339  SER A H    1 
ATOM   2285 H HA   . SER A 1 159 ? -36.56822 10.16209  -2.80661  1.000 28.06210 ? 339  SER A HA   1 
ATOM   2286 H HB2  . SER A 1 159 ? -34.40266 8.60298   -1.89367  1.000 27.20457 ? 339  SER A HB2  1 
ATOM   2287 H HB3  . SER A 1 159 ? -34.33037 10.18130  -2.06423  1.000 27.20457 ? 339  SER A HB3  1 
ATOM   2288 H HG   . SER A 1 159 ? -34.87291 9.59067   -0.00848  1.000 29.38933 ? 339  SER A HG   1 
ATOM   2289 N N    . GLY A 1 160 ? -35.60081 8.39418   -5.10132  1.000 21.55561 ? 340  GLY A N    1 
ATOM   2290 C CA   . GLY A 1 160 ? -35.14338 8.44326   -6.48274  1.000 21.27359 ? 340  GLY A CA   1 
ATOM   2291 C C    . GLY A 1 160 ? -33.63766 8.39782   -6.57446  1.000 21.73412 ? 340  GLY A C    1 
ATOM   2292 O O    . GLY A 1 160 ? -32.95848 7.66214   -5.84597  1.000 20.08794 ? 340  GLY A O    1 
ATOM   2293 H H    . GLY A 1 160 ? -35.97502 7.65262   -4.87848  1.000 25.86673 ? 340  GLY A H    1 
ATOM   2294 H HA2  . GLY A 1 160 ? -35.50485 7.68688   -6.97074  1.000 25.52831 ? 340  GLY A HA2  1 
ATOM   2295 H HA3  . GLY A 1 160 ? -35.45281 9.26371   -6.89749  1.000 25.52831 ? 340  GLY A HA3  1 
ATOM   2296 N N    . GLY A 1 161 ? -33.09981 9.17888   -7.50399  1.000 17.03145 ? 341  GLY A N    1 
ATOM   2297 C CA   . GLY A 1 161 ? -31.65347 9.28073   -7.59316  1.000 15.52861 ? 341  GLY A CA   1 
ATOM   2298 C C    . GLY A 1 161 ? -30.93629 8.06803   -8.14539  1.000 18.07931 ? 341  GLY A C    1 
ATOM   2299 O O    . GLY A 1 161 ? -29.71426 7.98080   -7.96425  1.000 16.66454 ? 341  GLY A O    1 
ATOM   2300 H H    . GLY A 1 161 ? -33.53892 9.64581   -8.07737  1.000 20.43774 ? 341  GLY A H    1 
ATOM   2301 H HA2  . GLY A 1 161 ? -31.43414 10.03346  -8.16428  1.000 18.63433 ? 341  GLY A HA2  1 
ATOM   2302 H HA3  . GLY A 1 161 ? -31.30277 9.44619   -6.70404  1.000 18.63433 ? 341  GLY A HA3  1 
ATOM   2303 N N    . ILE A 1 162 ? -31.63027 7.16933   -8.82846  1.000 17.00538 ? 342  ILE A N    1 
ATOM   2304 C CA   . ILE A 1 162 ? -30.95031 6.03580   -9.43719  1.000 17.70709 ? 342  ILE A CA   1 
ATOM   2305 C C    . ILE A 1 162 ? -30.12355 6.54449   -10.59991 1.000 19.69632 ? 342  ILE A C    1 
ATOM   2306 O O    . ILE A 1 162 ? -30.57912 7.39273   -11.39931 1.000 17.63618 ? 342  ILE A O    1 
ATOM   2307 C CB   . ILE A 1 162 ? -31.99064 5.01525   -9.88927  1.000 19.48069 ? 342  ILE A CB   1 
ATOM   2308 C CG1  . ILE A 1 162 ? -32.61026 4.34027   -8.65737  1.000 18.44436 ? 342  ILE A CG1  1 
ATOM   2309 C CG2  . ILE A 1 162 ? -31.36889 3.93852   -10.78607 1.000 22.66970 ? 342  ILE A CG2  1 
ATOM   2310 C CD1  . ILE A 1 162 ? -33.77791 3.42194   -8.93351  1.000 23.97319 ? 342  ILE A CD1  1 
ATOM   2311 H H    . ILE A 1 162 ? -32.48098 7.19180   -8.95249  1.000 20.40646 ? 342  ILE A H    1 
ATOM   2312 H HA   . ILE A 1 162 ? -30.35653 5.60553   -8.80221  1.000 21.24851 ? 342  ILE A HA   1 
ATOM   2313 H HB   . ILE A 1 162 ? -32.66834 5.48745   -10.39784 1.000 23.37683 ? 342  ILE A HB   1 
ATOM   2314 H HG12 . ILE A 1 162 ? -31.92373 3.81057   -8.22265  1.000 22.13323 ? 342  ILE A HG12 1 
ATOM   2315 H HG13 . ILE A 1 162 ? -32.92487 5.03344   -8.05617  1.000 22.13323 ? 342  ILE A HG13 1 
ATOM   2316 H HG21 . ILE A 1 162 ? -32.00374 3.21331   -10.89533 1.000 27.20364 ? 342  ILE A HG21 1 
ATOM   2317 H HG22 . ILE A 1 162 ? -31.16029 4.32842   -11.64941 1.000 27.20364 ? 342  ILE A HG22 1 
ATOM   2318 H HG23 . ILE A 1 162 ? -30.55841 3.60841   -10.36767 1.000 27.20364 ? 342  ILE A HG23 1 
ATOM   2319 H HD11 . ILE A 1 162 ? -34.22479 3.21896   -8.09684  1.000 28.76783 ? 342  ILE A HD11 1 
ATOM   2320 H HD12 . ILE A 1 162 ? -34.39306 3.86618   -9.53778  1.000 28.76783 ? 342  ILE A HD12 1 
ATOM   2321 H HD13 . ILE A 1 162 ? -33.44804 2.60485   -9.33904  1.000 28.76783 ? 342  ILE A HD13 1 
ATOM   2322 N N    . LEU A 1 163 ? -28.88117 6.05576   -10.69266 1.000 16.35117 ? 343  LEU A N    1 
ATOM   2323 C CA   . LEU A 1 163 ? -28.06878 6.18552   -11.90179 1.000 16.10011 ? 343  LEU A CA   1 
ATOM   2324 C C    . LEU A 1 163 ? -28.47589 5.04648   -12.83894 1.000 16.11462 ? 343  LEU A C    1 
ATOM   2325 O O    . LEU A 1 163 ? -28.19552 3.87869   -12.52964 1.000 18.08803 ? 343  LEU A O    1 
ATOM   2326 C CB   . LEU A 1 163 ? -26.57910 6.09218   -11.56442 1.000 16.65942 ? 343  LEU A CB   1 
ATOM   2327 C CG   . LEU A 1 163 ? -25.70164 6.10531   -12.82365 1.000 16.21888 ? 343  LEU A CG   1 
ATOM   2328 C CD1  . LEU A 1 163 ? -25.71729 7.48576   -13.54368 1.000 17.72317 ? 343  LEU A CD1  1 
ATOM   2329 C CD2  . LEU A 1 163 ? -24.29551 5.68608   -12.51461 1.000 16.90987 ? 343  LEU A CD2  1 
ATOM   2330 H H    . LEU A 1 163 ? -28.48180 5.63785   -10.05591 1.000 19.62141 ? 343  LEU A H    1 
ATOM   2331 H HA   . LEU A 1 163 ? -28.22804 7.04437   -12.32359 1.000 19.32013 ? 343  LEU A HA   1 
ATOM   2332 H HB2  . LEU A 1 163 ? -26.33014 6.84995   -11.01242 1.000 19.99131 ? 343  LEU A HB2  1 
ATOM   2333 H HB3  . LEU A 1 163 ? -26.41270 5.26467   -11.08647 1.000 19.99131 ? 343  LEU A HB3  1 
ATOM   2334 H HG   . LEU A 1 163 ? -26.07944 5.45975   -13.44125 1.000 19.46266 ? 343  LEU A HG   1 
ATOM   2335 H HD11 . LEU A 1 163 ? -25.11437 7.45283   -14.30283 1.000 21.26780 ? 343  LEU A HD11 1 
ATOM   2336 H HD12 . LEU A 1 163 ? -26.61959 7.67414   -13.84581 1.000 21.26780 ? 343  LEU A HD12 1 
ATOM   2337 H HD13 . LEU A 1 163 ? -25.42744 8.17028   -12.92053 1.000 21.26780 ? 343  LEU A HD13 1 
ATOM   2338 H HD21 . LEU A 1 163 ? -23.77050 5.71662   -13.32968 1.000 20.29184 ? 343  LEU A HD21 1 
ATOM   2339 H HD22 . LEU A 1 163 ? -23.92191 6.29399   -11.85753 1.000 20.29184 ? 343  LEU A HD22 1 
ATOM   2340 H HD23 . LEU A 1 163 ? -24.30571 4.78274   -12.16138 1.000 20.29184 ? 343  LEU A HD23 1 
ATOM   2341 N N    . ARG A 1 164 ? -29.20742 5.36198   -13.89708 1.000 15.70145 ? 344  ARG A N    1 
ATOM   2342 C CA   . ARG A 1 164 ? -29.59443 4.37474   -14.89962 1.000 17.02737 ? 344  ARG A CA   1 
ATOM   2343 C C    . ARG A 1 164 ? -28.58340 4.44009   -16.04560 1.000 13.58520 ? 344  ARG A C    1 
ATOM   2344 O O    . ARG A 1 164 ? -28.41039 5.47341   -16.67632 1.000 14.94744 ? 344  ARG A O    1 
ATOM   2345 C CB   . ARG A 1 164 ? -31.04235 4.54703   -15.37636 1.000 16.01323 ? 344  ARG A CB   1 
ATOM   2346 C CG   . ARG A 1 164 ? -31.43180 3.56948   -16.50010 1.000 17.31825 ? 344  ARG A CG   1 
ATOM   2347 C CD   . ARG A 1 164 ? -32.94040 3.57887   -16.70329 1.000 18.65220 ? 344  ARG A CD   1 
ATOM   2348 N NE   . ARG A 1 164 ? -33.57465 2.89651   -15.58621 1.000 18.45401 ? 344  ARG A NE   1 
ATOM   2349 C CZ   . ARG A 1 164 ? -34.88701 2.73064   -15.45270 1.000 22.22944 ? 344  ARG A CZ   1 
ATOM   2350 N NH1  . ARG A 1 164 ? -35.74066 3.24577   -16.32641 1.000 23.40890 ? 344  ARG A NH1  1 
ATOM   2351 N NH2  . ARG A 1 164 ? -35.35472 1.98371   -14.44511 1.000 25.53995 ? 344  ARG A NH2  1 
ATOM   2352 H H    . ARG A 1 164 ? -29.49788 6.15463   -14.06121 1.000 18.84174 ? 344  ARG A H    1 
ATOM   2353 H HA   . ARG A 1 164 ? -29.55926 3.48652   -14.51137 1.000 20.43284 ? 344  ARG A HA   1 
ATOM   2354 H HB2  . ARG A 1 164 ? -31.63964 4.39413   -14.62752 1.000 19.21588 ? 344  ARG A HB2  1 
ATOM   2355 H HB3  . ARG A 1 164 ? -31.15665 5.44953   -15.71301 1.000 19.21588 ? 344  ARG A HB3  1 
ATOM   2356 H HG2  . ARG A 1 164 ? -31.00512 3.83796   -17.32882 1.000 20.78190 ? 344  ARG A HG2  1 
ATOM   2357 H HG3  . ARG A 1 164 ? -31.15619 2.67071   -16.26106 1.000 20.78190 ? 344  ARG A HG3  1 
ATOM   2358 H HD2  . ARG A 1 164 ? -33.26324 4.49288   -16.73871 1.000 22.38264 ? 344  ARG A HD2  1 
ATOM   2359 H HD3  . ARG A 1 164 ? -33.16592 3.11529   -17.52495 1.000 22.38264 ? 344  ARG A HD3  1 
ATOM   2360 H HE   . ARG A 1 164 ? -33.06595 2.57861   -14.96996 1.000 22.14481 ? 344  ARG A HE   1 
ATOM   2361 H HH11 . ARG A 1 164 ? -35.44897 3.69834   -16.99701 1.000 28.09068 ? 344  ARG A HH11 1 
ATOM   2362 H HH12 . ARG A 1 164 ? -36.58612 3.12738   -16.22261 1.000 28.09068 ? 344  ARG A HH12 1 
ATOM   2363 H HH21 . ARG A 1 164 ? -34.80787 1.61671   -13.89205 1.000 30.64794 ? 344  ARG A HH21 1 
ATOM   2364 H HH22 . ARG A 1 164 ? -36.20205 1.87083   -14.35083 1.000 30.64794 ? 344  ARG A HH22 1 
ATOM   2365 N N    . ILE A 1 165 ? -27.90017 3.33655   -16.29877 1.000 15.41792 ? 345  ILE A N    1 
ATOM   2366 C CA   . ILE A 1 165 ? -26.95306 3.22258   -17.39999 1.000 15.89602 ? 345  ILE A CA   1 
ATOM   2367 C C    . ILE A 1 165 ? -27.59558 2.36067   -18.46792 1.000 15.18018 ? 345  ILE A C    1 
ATOM   2368 O O    . ILE A 1 165 ? -28.26278 1.36159   -18.14640 1.000 16.67349 ? 345  ILE A O    1 
ATOM   2369 C CB   . ILE A 1 165 ? -25.65212 2.57208   -16.92408 1.000 16.04211 ? 345  ILE A CB   1 
ATOM   2370 C CG1  . ILE A 1 165 ? -25.11520 3.26651   -15.66246 1.000 16.36364 ? 345  ILE A CG1  1 
ATOM   2371 C CG2  . ILE A 1 165 ? -24.57216 2.63405   -18.03981 1.000 17.83806 ? 345  ILE A CG2  1 
ATOM   2372 C CD1  . ILE A 1 165 ? -23.95673 2.54607   -15.01444 1.000 17.61460 ? 345  ILE A CD1  1 
ATOM   2373 H H    . ILE A 1 165 ? -27.96885 2.61680   -15.83311 1.000 18.50151 ? 345  ILE A H    1 
ATOM   2374 H HA   . ILE A 1 165 ? -26.75739 4.10011   -17.76407 1.000 19.07523 ? 345  ILE A HA   1 
ATOM   2375 H HB   . ILE A 1 165 ? -25.85136 1.64638   -16.71364 1.000 19.25053 ? 345  ILE A HB   1 
ATOM   2376 H HG12 . ILE A 1 165 ? -24.81317 4.15673   -15.90159 1.000 19.63637 ? 345  ILE A HG12 1 
ATOM   2377 H HG13 . ILE A 1 165 ? -25.83051 3.32303   -15.00975 1.000 19.63637 ? 345  ILE A HG13 1 
ATOM   2378 H HG21 . ILE A 1 165 ? -23.78203 2.15704   -17.74137 1.000 21.40568 ? 345  ILE A HG21 1 
ATOM   2379 H HG22 . ILE A 1 165 ? -24.92431 2.22056   -18.84350 1.000 21.40568 ? 345  ILE A HG22 1 
ATOM   2380 H HG23 . ILE A 1 165 ? -24.35174 3.56234   -18.21476 1.000 21.40568 ? 345  ILE A HG23 1 
ATOM   2381 H HD11 . ILE A 1 165 ? -23.77905 2.94770   -14.14955 1.000 21.13752 ? 345  ILE A HD11 1 
ATOM   2382 H HD12 . ILE A 1 165 ? -24.18874 1.61079   -14.90343 1.000 21.13752 ? 345  ILE A HD12 1 
ATOM   2383 H HD13 . ILE A 1 165 ? -23.17569 2.62780   -15.58382 1.000 21.13752 ? 345  ILE A HD13 1 
ATOM   2384 N N    . PHE A 1 166 ? -27.36789 2.73062   -19.73396 1.000 16.88042 ? 346  PHE A N    1 
ATOM   2385 C CA   . PHE A 1 166 ? -27.90914 2.01591   -20.87484 1.000 16.94071 ? 346  PHE A CA   1 
ATOM   2386 C C    . PHE A 1 166 ? -26.76541 1.40068   -21.65312 1.000 18.53420 ? 346  PHE A C    1 
ATOM   2387 O O    . PHE A 1 166 ? -26.44055 1.86481   -22.74637 1.000 19.15624 ? 346  PHE A O    1 
ATOM   2388 C CB   . PHE A 1 166 ? -28.67952 2.99197   -21.76683 1.000 18.80288 ? 346  PHE A CB   1 
ATOM   2389 C CG   . PHE A 1 166 ? -29.80470 3.69739   -21.06314 1.000 17.46532 ? 346  PHE A CG   1 
ATOM   2390 C CD1  . PHE A 1 166 ? -31.05022 3.09745   -20.93684 1.000 19.11226 ? 346  PHE A CD1  1 
ATOM   2391 C CD2  . PHE A 1 166 ? -29.64673 4.95136   -20.56427 1.000 17.91043 ? 346  PHE A CD2  1 
ATOM   2392 C CE1  . PHE A 1 166 ? -32.08467 3.71341   -20.30713 1.000 19.44090 ? 346  PHE A CE1  1 
ATOM   2393 C CE2  . PHE A 1 166 ? -30.70200 5.61244   -19.94928 1.000 21.93359 ? 346  PHE A CE2  1 
ATOM   2394 C CZ   . PHE A 1 166 ? -31.92556 4.97704   -19.84940 1.000 19.80790 ? 346  PHE A CZ   1 
ATOM   2395 H H    . PHE A 1 166 ? -26.88992 3.41053   -19.95502 1.000 20.25650 ? 346  PHE A H    1 
ATOM   2396 H HA   . PHE A 1 166 ? -28.50942 1.31161   -20.58411 1.000 20.32885 ? 346  PHE A HA   1 
ATOM   2397 H HB2  . PHE A 1 166 ? -28.06483 3.66761   -22.09327 1.000 22.56346 ? 346  PHE A HB2  1 
ATOM   2398 H HB3  . PHE A 1 166 ? -29.05858 2.50041   -22.51220 1.000 22.56346 ? 346  PHE A HB3  1 
ATOM   2399 H HD1  . PHE A 1 166 ? -31.18043 2.24865   -21.29389 1.000 22.93471 ? 346  PHE A HD1  1 
ATOM   2400 H HD2  . PHE A 1 166 ? -28.82071 5.37269   -20.63560 1.000 21.49252 ? 346  PHE A HD2  1 
ATOM   2401 H HE1  . PHE A 1 166 ? -32.89444 3.27086   -20.19172 1.000 23.32909 ? 346  PHE A HE1  1 
ATOM   2402 H HE2  . PHE A 1 166 ? -30.58708 6.47047   -19.60946 1.000 26.32030 ? 346  PHE A HE2  1 
ATOM   2403 H HZ   . PHE A 1 166 ? -32.64579 5.42183   -19.46426 1.000 23.76948 ? 346  PHE A HZ   1 
ATOM   2404 N N    . PRO A 1 167 ? -26.14073 0.33997   -21.16196 1.000 18.33416 ? 347  PRO A N    1 
ATOM   2405 C CA   . PRO A 1 167 ? -24.98055 -0.20817  -21.87968 1.000 19.42883 ? 347  PRO A CA   1 
ATOM   2406 C C    . PRO A 1 167 ? -25.37773 -0.66669  -23.27006 1.000 21.05395 ? 347  PRO A C    1 
ATOM   2407 O O    . PRO A 1 167 ? -26.35309 -1.41467  -23.45885 1.000 22.73160 ? 347  PRO A O    1 
ATOM   2408 C CB   . PRO A 1 167 ? -24.52771 -1.36650  -20.99001 1.000 19.65321 ? 347  PRO A CB   1 
ATOM   2409 C CG   . PRO A 1 167 ? -25.76494 -1.72854  -20.19586 1.000 21.87955 ? 347  PRO A CG   1 
ATOM   2410 C CD   . PRO A 1 167 ? -26.50085 -0.45055  -19.97254 1.000 19.54403 ? 347  PRO A CD   1 
ATOM   2411 H HA   . PRO A 1 167 ? -24.26440 0.44300   -21.94293 1.000 23.31460 ? 347  PRO A HA   1 
ATOM   2412 H HB2  . PRO A 1 167 ? -24.23206 -2.11123  -21.53670 1.000 23.58386 ? 347  PRO A HB2  1 
ATOM   2413 H HB3  . PRO A 1 167 ? -23.80892 -1.07756  -20.40625 1.000 23.58386 ? 347  PRO A HB3  1 
ATOM   2414 H HG2  . PRO A 1 167 ? -26.30746 -2.35226  -20.70336 1.000 26.25546 ? 347  PRO A HG2  1 
ATOM   2415 H HG3  . PRO A 1 167 ? -25.50503 -2.12662  -19.35036 1.000 26.25546 ? 347  PRO A HG3  1 
ATOM   2416 H HD2  . PRO A 1 167 ? -27.45801 -0.60272  -19.93276 1.000 23.45283 ? 347  PRO A HD2  1 
ATOM   2417 H HD3  . PRO A 1 167 ? -26.20037 -0.01350  -19.16038 1.000 23.45283 ? 347  PRO A HD3  1 
ATOM   2418 N N    . GLU A 1 168 ? -24.60099 -0.23318  -24.24896 1.000 22.45189 ? 348  GLU A N    1 
ATOM   2419 C CA   . GLU A 1 168 ? -24.86643 -0.58000  -25.62922 1.000 24.51153 ? 348  GLU A CA   1 
ATOM   2420 C C    . GLU A 1 168 ? -24.84056 -2.09731  -25.81773 1.000 30.91459 ? 348  GLU A C    1 
ATOM   2421 O O    . GLU A 1 168 ? -23.99792 -2.80587  -25.25709 1.000 27.91884 ? 348  GLU A O    1 
ATOM   2422 C CB   . GLU A 1 168 ? -23.80624 0.06649   -26.52609 1.000 29.97951 ? 348  GLU A CB   1 
ATOM   2423 C CG   . GLU A 1 168 ? -24.13172 0.07173   -28.01646 1.000 44.73728 ? 348  GLU A CG   1 
ATOM   2424 H H    . GLU A 1 168 ? -23.90972 0.26636   -24.13849 1.000 26.94227 ? 348  GLU A H    1 
ATOM   2425 H HA   . GLU A 1 168 ? -25.74398 -0.25556  -25.88522 1.000 29.41383 ? 348  GLU A HA   1 
ATOM   2426 H HB2  . GLU A 1 168 ? -23.69379 0.98972   -26.25060 1.000 35.97541 ? 348  GLU A HB2  1 
ATOM   2427 H HB3  . GLU A 1 168 ? -22.97314 -0.41730  -26.41294 1.000 35.97541 ? 348  GLU A HB3  1 
ATOM   2428 H HG2  . GLU A 1 168 ? -24.07281 -0.82334  -28.37404 1.000 53.68474 ? 348  GLU A HG2  1 
ATOM   2429 H HG3  . GLU A 1 168 ? -25.02469 0.43169   -28.14751 1.000 53.68474 ? 348  GLU A HG3  1 
ATOM   2430 N N    . GLY A 1 169 ? -25.81534 -2.58290  -26.57826 1.000 27.71522 ? 349  GLY A N    1 
ATOM   2431 C CA   . GLY A 1 169 ? -25.87732 -3.96960  -26.97931 1.000 31.65413 ? 349  GLY A CA   1 
ATOM   2432 C C    . GLY A 1 169 ? -26.49608 -4.90741  -25.97418 1.000 36.87949 ? 349  GLY A C    1 
ATOM   2433 O O    . GLY A 1 169 ? -26.51842 -6.12302  -26.22526 1.000 38.57939 ? 349  GLY A O    1 
ATOM   2434 H H    . GLY A 1 169 ? -26.46786 -2.11094  -26.88003 1.000 33.25826 ? 349  GLY A H    1 
ATOM   2435 H HA2  . GLY A 1 169 ? -26.39646 -4.03123  -27.79637 1.000 37.98496 ? 349  GLY A HA2  1 
ATOM   2436 H HA3  . GLY A 1 169 ? -24.97528 -4.28052  -27.15408 1.000 37.98496 ? 349  GLY A HA3  1 
ATOM   2437 N N    . LYS A 1 170 ? -27.00602 -4.40314  -24.86138 1.000 27.29804 ? 350  LYS A N    1 
ATOM   2438 C CA   . LYS A 1 170 ? -27.51336 -5.24633  -23.78554 1.000 27.06804 ? 350  LYS A CA   1 
ATOM   2439 C C    . LYS A 1 170 ? -29.03978 -5.23744  -23.79227 1.000 26.26348 ? 350  LYS A C    1 
ATOM   2440 O O    . LYS A 1 170 ? -29.67415 -4.22148  -24.09356 1.000 26.32964 ? 350  LYS A O    1 
ATOM   2441 C CB   . LYS A 1 170 ? -26.99388 -4.73382  -22.42852 1.000 23.49720 ? 350  LYS A CB   1 
ATOM   2442 C CG   . LYS A 1 170 ? -25.47994 -4.77393  -22.27399 1.000 27.14329 ? 350  LYS A CG   1 
ATOM   2443 C CD   . LYS A 1 170 ? -25.04384 -6.15736  -21.75942 1.000 40.24150 ? 350  LYS A CD   1 
ATOM   2444 C CE   . LYS A 1 170 ? -23.72579 -6.14646  -20.97064 1.000 34.74996 ? 350  LYS A CE   1 
ATOM   2445 N NZ   . LYS A 1 170 ? -23.07436 -7.47547  -20.87834 1.000 32.63772 ? 350  LYS A NZ   1 
ATOM   2446 H H    . LYS A 1 170 ? -27.07097 -3.56062  -24.70156 1.000 32.75765 ? 350  LYS A H    1 
ATOM   2447 H HA   . LYS A 1 170 ? -27.21978 -6.16257  -23.90888 1.000 32.48164 ? 350  LYS A HA   1 
ATOM   2448 H HB2  . LYS A 1 170 ? -27.27492 -3.81194  -22.31870 1.000 28.19663 ? 350  LYS A HB2  1 
ATOM   2449 H HB3  . LYS A 1 170 ? -27.37448 -5.28271  -21.72512 1.000 28.19663 ? 350  LYS A HB3  1 
ATOM   2450 H HG2  . LYS A 1 170 ? -25.05861 -4.61369  -23.13288 1.000 32.57195 ? 350  LYS A HG2  1 
ATOM   2451 H HG3  . LYS A 1 170 ? -25.19787 -4.10056  -21.63531 1.000 32.57195 ? 350  LYS A HG3  1 
ATOM   2452 H HD2  . LYS A 1 170 ? -25.73449 -6.50316  -21.17263 1.000 48.28980 ? 350  LYS A HD2  1 
ATOM   2453 H HD3  . LYS A 1 170 ? -24.92679 -6.74929  -22.51890 1.000 48.28980 ? 350  LYS A HD3  1 
ATOM   2454 H HE2  . LYS A 1 170 ? -23.10498 -5.54275  -21.40771 1.000 41.69996 ? 350  LYS A HE2  1 
ATOM   2455 H HE3  . LYS A 1 170 ? -23.90465 -5.84161  -20.06733 1.000 41.69996 ? 350  LYS A HE3  1 
ATOM   2456 H HZ1  . LYS A 1 170 ? -23.51517 -7.99118  -20.30229 1.000 39.16527 ? 350  LYS A HZ1  1 
ATOM   2457 H HZ2  . LYS A 1 170 ? -22.23410 -7.38390  -20.59962 1.000 39.16527 ? 350  LYS A HZ2  1 
ATOM   2458 H HZ3  . LYS A 1 170 ? -23.07266 -7.86971  -21.67625 1.000 39.16527 ? 350  LYS A HZ3  1 
ATOM   2459 N N    . ALA A 1 171 ? -29.61364 -6.37407  -23.41428 1.000 26.16267 ? 351  ALA A N    1 
ATOM   2460 C CA   . ALA A 1 171 ? -31.04998 -6.53271  -23.31335 1.000 26.41199 ? 351  ALA A CA   1 
ATOM   2461 C C    . ALA A 1 171 ? -31.61147 -5.92949  -22.03794 1.000 25.04902 ? 351  ALA A C    1 
ATOM   2462 O O    . ALA A 1 171 ? -32.78476 -6.13515  -21.74356 1.000 26.33331 ? 351  ALA A O    1 
ATOM   2463 C CB   . ALA A 1 171 ? -31.43053 -8.01246  -23.34380 1.000 28.68342 ? 351  ALA A CB   1 
ATOM   2464 H H    . ALA A 1 171 ? -29.17676 -7.08499  -23.20614 1.000 31.39521 ? 351  ALA A H    1 
ATOM   2465 H HA   . ALA A 1 171 ? -31.45306 -6.09606  -24.08000 1.000 31.69439 ? 351  ALA A HA   1 
ATOM   2466 H HB1  . ALA A 1 171 ? -32.39582 -8.09146  -23.29016 1.000 34.42011 ? 351  ALA A HB1  1 
ATOM   2467 H HB2  . ALA A 1 171 ? -31.11219 -8.40341  -24.17249 1.000 34.42011 ? 351  ALA A HB2  1 
ATOM   2468 H HB3  . ALA A 1 171 ? -31.01950 -8.45987  -22.58764 1.000 34.42011 ? 351  ALA A HB3  1 
ATOM   2469 N N    . GLN A 1 172 ? -30.81124 -5.26022  -21.23492 1.000 24.96222 ? 352  GLN A N    1 
ATOM   2470 C CA   . GLN A 1 172 ? -31.33096 -4.66232  -20.01974 1.000 22.54393 ? 352  GLN A CA   1 
ATOM   2471 C C    . GLN A 1 172 ? -30.51015 -3.41676  -19.75519 1.000 26.85021 ? 352  GLN A C    1 
ATOM   2472 O O    . GLN A 1 172 ? -29.37024 -3.30666  -20.21350 1.000 31.86152 ? 352  GLN A O    1 
ATOM   2473 C CB   . GLN A 1 172 ? -31.27300 -5.61919  -18.81744 1.000 26.46053 ? 352  GLN A CB   1 
ATOM   2474 H H    . GLN A 1 172 ? -29.97048 -5.13793  -21.36825 1.000 29.95466 ? 352  GLN A H    1 
ATOM   2475 H HA   . GLN A 1 172 ? -32.26359 -4.42161  -20.13448 1.000 27.05272 ? 352  GLN A HA   1 
ATOM   2476 N N    . PHE A 1 173 ? -31.08143 -2.47428  -19.04393 1.000 21.94595 ? 353  PHE A N    1 
ATOM   2477 C CA   . PHE A 1 173 ? -30.26885 -1.37470  -18.52881 1.000 20.55019 ? 353  PHE A CA   1 
ATOM   2478 C C    . PHE A 1 173 ? -29.84399 -1.74530  -17.11654 1.000 20.68051 ? 353  PHE A C    1 
ATOM   2479 O O    . PHE A 1 173 ? -30.28301 -2.75444  -16.54914 1.000 25.07320 ? 353  PHE A O    1 
ATOM   2480 C CB   . PHE A 1 173 ? -30.94505 0.00331   -18.67358 1.000 30.54092 ? 353  PHE A CB   1 
ATOM   2481 C CG   . PHE A 1 173 ? -32.40128 0.01784   -18.37054 1.000 24.29428 ? 353  PHE A CG   1 
ATOM   2482 C CD1  . PHE A 1 173 ? -32.82895 -0.09681  -17.06689 1.000 28.46187 ? 353  PHE A CD1  1 
ATOM   2483 C CD2  . PHE A 1 173 ? -33.32818 0.23894   -19.37707 1.000 30.37710 ? 353  PHE A CD2  1 
ATOM   2484 C CE1  . PHE A 1 173 ? -34.16753 -0.06201  -16.75739 1.000 23.81807 ? 353  PHE A CE1  1 
ATOM   2485 C CE2  . PHE A 1 173 ? -34.67484 0.29284   -19.08990 1.000 25.78788 ? 353  PHE A CE2  1 
ATOM   2486 C CZ   . PHE A 1 173 ? -35.10257 0.14885   -17.76563 1.000 30.21477 ? 353  PHE A CZ   1 
ATOM   2487 H H    . PHE A 1 173 ? -31.91762 -2.44168  -18.84563 1.000 26.33514 ? 353  PHE A H    1 
ATOM   2488 H HA   . PHE A 1 173 ? -29.46690 -1.25135  -19.06037 1.000 24.66023 ? 353  PHE A HA   1 
ATOM   2489 H HB2  . PHE A 1 173 ? -30.51415 0.62328   -18.06460 1.000 36.64911 ? 353  PHE A HB2  1 
ATOM   2490 H HB3  . PHE A 1 173 ? -30.83443 0.30602   -19.58847 1.000 36.64911 ? 353  PHE A HB3  1 
ATOM   2491 H HD1  . PHE A 1 173 ? -32.20341 -0.19923  -16.38636 1.000 34.15425 ? 353  PHE A HD1  1 
ATOM   2492 H HD2  . PHE A 1 173 ? -33.03880 0.35188   -20.25366 1.000 36.45252 ? 353  PHE A HD2  1 
ATOM   2493 H HE1  . PHE A 1 173 ? -34.44694 -0.17886  -15.87808 1.000 28.58169 ? 353  PHE A HE1  1 
ATOM   2494 H HE2  . PHE A 1 173 ? -35.29444 0.42388   -19.77096 1.000 30.94546 ? 353  PHE A HE2  1 
ATOM   2495 H HZ   . PHE A 1 173 ? -36.00847 0.19393   -17.56017 1.000 36.25772 ? 353  PHE A HZ   1 
ATOM   2496 N N    . ALA A 1 174 ? -28.90904 -0.99052  -16.59042 1.000 18.23979 ? 354  ALA A N    1 
ATOM   2497 C CA   . ALA A 1 174 ? -28.28089 -1.23520  -15.28983 1.000 16.72717 ? 354  ALA A CA   1 
ATOM   2498 C C    . ALA A 1 174 ? -28.69969 -0.10350  -14.36056 1.000 17.31448 ? 354  ALA A C    1 
ATOM   2499 O O    . ALA A 1 174 ? -28.32419 1.05884   -14.59234 1.000 19.86127 ? 354  ALA A O    1 
ATOM   2500 C CB   . ALA A 1 174 ? -26.76793 -1.24176  -15.42305 1.000 18.43367 ? 354  ALA A CB   1 
ATOM   2501 H H    . ALA A 1 174 ? -28.59695 -0.29010  -16.97979 1.000 21.88775 ? 354  ALA A H    1 
ATOM   2502 H HA   . ALA A 1 174 ? -28.58073 -2.08754  -14.93698 1.000 20.07261 ? 354  ALA A HA   1 
ATOM   2503 H HB1  . ALA A 1 174 ? -26.37510 -1.41636  -14.55351 1.000 22.12040 ? 354  ALA A HB1  1 
ATOM   2504 H HB2  . ALA A 1 174 ? -26.50899 -1.93648  -16.04852 1.000 22.12040 ? 354  ALA A HB2  1 
ATOM   2505 H HB3  . ALA A 1 174 ? -26.47595 -0.37653  -15.75021 1.000 22.12040 ? 354  ALA A HB3  1 
ATOM   2506 N N    . ASP A 1 175 ? -29.48821 -0.41348  -13.34749 1.000 19.74190 ? 355  ASP A N    1 
ATOM   2507 C CA   . ASP A 1 175 ? -29.93014 0.57913   -12.37272 1.000 19.03193 ? 355  ASP A CA   1 
ATOM   2508 C C    . ASP A 1 175 ? -29.01624 0.50291   -11.16033 1.000 19.26764 ? 355  ASP A C    1 
ATOM   2509 O O    . ASP A 1 175 ? -28.98922 -0.52798  -10.46972 1.000 21.73788 ? 355  ASP A O    1 
ATOM   2510 C CB   . ASP A 1 175 ? -31.38164 0.34382   -11.98608 1.000 20.23224 ? 355  ASP A CB   1 
ATOM   2511 C CG   . ASP A 1 175 ? -32.35551 0.74935   -13.09741 1.000 21.94875 ? 355  ASP A CG   1 
ATOM   2512 O OD1  . ASP A 1 175 ? -31.96143 1.63018   -13.88149 1.000 21.87038 ? 355  ASP A OD1  1 
ATOM   2513 O OD2  . ASP A 1 175 ? -33.46615 0.19845   -13.17417 1.000 26.42160 ? 355  ASP A OD2  1 
ATOM   2514 H H    . ASP A 1 175 ? -29.78841 -1.20518  -13.19686 1.000 23.69028 ? 355  ASP A H    1 
ATOM   2515 H HA   . ASP A 1 175 ? -29.86450 1.47075   -12.74904 1.000 22.83832 ? 355  ASP A HA   1 
ATOM   2516 H HB2  . ASP A 1 175 ? -31.51181 -0.59935  -11.80064 1.000 24.27869 ? 355  ASP A HB2  1 
ATOM   2517 H HB3  . ASP A 1 175 ? -31.58908 0.86875   -11.19721 1.000 24.27869 ? 355  ASP A HB3  1 
ATOM   2518 N N    . ILE A 1 176 ? -28.30102 1.58060   -10.89139 1.000 17.10118 ? 356  ILE A N    1 
ATOM   2519 C CA   . ILE A 1 176 ? -27.35468 1.67485   -9.78600  1.000 16.10623 ? 356  ILE A CA   1 
ATOM   2520 C C    . ILE A 1 176 ? -27.97321 2.61176   -8.76064  1.000 15.34243 ? 356  ILE A C    1 
ATOM   2521 O O    . ILE A 1 176 ? -27.96830 3.84114   -8.95414  1.000 16.20619 ? 356  ILE A O    1 
ATOM   2522 C CB   . ILE A 1 176 ? -25.98299 2.19886   -10.23649 1.000 17.00132 ? 356  ILE A CB   1 
ATOM   2523 C CG1  . ILE A 1 176 ? -25.49623 1.51317   -11.51739 1.000 18.38486 ? 356  ILE A CG1  1 
ATOM   2524 C CG2  . ILE A 1 176 ? -24.96977 2.02151   -9.08970  1.000 20.81706 ? 356  ILE A CG2  1 
ATOM   2525 C CD1  . ILE A 1 176 ? -25.34306 0.09288   -11.40594 1.000 20.50786 ? 356  ILE A CD1  1 
ATOM   2526 H H    . ILE A 1 176 ? -28.34610 2.30425   -11.35389 1.000 20.52141 ? 356  ILE A H    1 
ATOM   2527 H HA   . ILE A 1 176 ? -27.23152 0.79646   -9.39336  1.000 19.32748 ? 356  ILE A HA   1 
ATOM   2528 H HB   . ILE A 1 176 ? -26.07200 3.14148   -10.44728 1.000 20.40159 ? 356  ILE A HB   1 
ATOM   2529 H HG12 . ILE A 1 176 ? -26.13877 1.68452   -12.22356 1.000 22.06184 ? 356  ILE A HG12 1 
ATOM   2530 H HG13 . ILE A 1 176 ? -24.63253 1.88353   -11.75769 1.000 22.06184 ? 356  ILE A HG13 1 
ATOM   2531 H HG21 . ILE A 1 176 ? -24.08092 2.22758   -9.41893  1.000 24.98048 ? 356  ILE A HG21 1 
ATOM   2532 H HG22 . ILE A 1 176 ? -25.20265 2.62449   -8.36646  1.000 24.98048 ? 356  ILE A HG22 1 
ATOM   2533 H HG23 . ILE A 1 176 ? -25.00260 1.10339   -8.77845  1.000 24.98048 ? 356  ILE A HG23 1 
ATOM   2534 H HD11 . ILE A 1 176 ? -25.04513 -0.26051  -12.25873 1.000 24.60943 ? 356  ILE A HD11 1 
ATOM   2535 H HD12 . ILE A 1 176 ? -24.68551 -0.10095  -10.71967 1.000 24.60943 ? 356  ILE A HD12 1 
ATOM   2536 H HD13 . ILE A 1 176 ? -26.19724 -0.29899  -11.16572 1.000 24.60943 ? 356  ILE A HD13 1 
ATOM   2537 N N    . GLU A 1 177 ? -28.49820 2.05624   -7.69409  1.000 16.68683 ? 357  GLU A N    1 
ATOM   2538 C CA   . GLU A 1 177 ? -28.94703 2.88583   -6.58918  1.000 16.22670 ? 357  GLU A CA   1 
ATOM   2539 C C    . GLU A 1 177 ? -27.70141 3.47225   -5.93065  1.000 17.19022 ? 357  GLU A C    1 
ATOM   2540 O O    . GLU A 1 177 ? -26.66246 2.80924   -5.85645  1.000 16.87141 ? 357  GLU A O    1 
ATOM   2541 C CB   . GLU A 1 177 ? -29.75051 2.06486   -5.58518  1.000 20.31091 ? 357  GLU A CB   1 
ATOM   2542 C CG   . GLU A 1 177 ? -31.04744 1.52933   -6.24404  1.000 19.28526 ? 357  GLU A CG   1 
ATOM   2543 C CD   . GLU A 1 177 ? -31.99877 0.78270   -5.34250  1.000 26.38237 ? 357  GLU A CD   1 
ATOM   2544 O OE1  . GLU A 1 177 ? -31.75663 0.65400   -4.12718  1.000 27.04034 ? 357  GLU A OE1  1 
ATOM   2545 O OE2  . GLU A 1 177 ? -33.03227 0.31121   -5.88812  1.000 35.27255 ? 357  GLU A OE2  1 
ATOM   2546 H H    . GLU A 1 177 ? -28.60745 1.21085   -7.58014  1.000 20.02420 ? 357  GLU A H    1 
ATOM   2547 H HA   . GLU A 1 177 ? -29.53166 3.59862   -6.89090  1.000 19.47203 ? 357  GLU A HA   1 
ATOM   2548 H HB2  . GLU A 1 177 ? -29.22054 1.31032   -5.28403  1.000 24.37309 ? 357  GLU A HB2  1 
ATOM   2549 H HB3  . GLU A 1 177 ? -29.99326 2.62246   -4.82950  1.000 24.37309 ? 357  GLU A HB3  1 
ATOM   2550 H HG2  . GLU A 1 177 ? -31.53494 2.28449   -6.60870  1.000 23.14232 ? 357  GLU A HG2  1 
ATOM   2551 H HG3  . GLU A 1 177 ? -30.79534 0.92171   -6.95687  1.000 23.14232 ? 357  GLU A HG3  1 
ATOM   2552 N N    . PRO A 1 178 ? -27.77780 4.70640   -5.44074  1.000 16.56284 ? 358  PRO A N    1 
ATOM   2553 C CA   . PRO A 1 178 ? -26.58001 5.39763   -4.89512  1.000 16.12050 ? 358  PRO A CA   1 
ATOM   2554 C C    . PRO A 1 178 ? -26.29926 4.99078   -3.45480  1.000 16.72841 ? 358  PRO A C    1 
ATOM   2555 O O    . PRO A 1 178 ? -26.24883 5.82868   -2.52732  1.000 16.66460 ? 358  PRO A O    1 
ATOM   2556 C CB   . PRO A 1 178 ? -26.96812 6.87609   -5.02130  1.000 17.15225 ? 358  PRO A CB   1 
ATOM   2557 C CG   . PRO A 1 178 ? -28.47596 6.87788   -4.81693  1.000 17.70786 ? 358  PRO A CG   1 
ATOM   2558 C CD   . PRO A 1 178 ? -28.94352 5.61617   -5.53047  1.000 18.45147 ? 358  PRO A CD   1 
ATOM   2559 H HA   . PRO A 1 178 ? -25.80268 5.22114   -5.44785  1.000 19.34460 ? 358  PRO A HA   1 
ATOM   2560 H HB2  . PRO A 1 178 ? -26.52064 7.39885   -4.33765  1.000 20.58270 ? 358  PRO A HB2  1 
ATOM   2561 H HB3  . PRO A 1 178 ? -26.73278 7.20973   -5.90118  1.000 20.58270 ? 358  PRO A HB3  1 
ATOM   2562 H HG2  . PRO A 1 178 ? -28.68582 6.84370   -3.87052  1.000 21.24944 ? 358  PRO A HG2  1 
ATOM   2563 H HG3  . PRO A 1 178 ? -28.86708 7.67125   -5.21504  1.000 21.24944 ? 358  PRO A HG3  1 
ATOM   2564 H HD2  . PRO A 1 178 ? -29.71325 5.23311   -5.08139  1.000 22.14176 ? 358  PRO A HD2  1 
ATOM   2565 H HD3  . PRO A 1 178 ? -29.16029 5.80598   -6.45669  1.000 22.14176 ? 358  PRO A HD3  1 
ATOM   2566 N N    . LYS A 1 179 ? -26.10786 3.68635   -3.26609  1.000 17.23265 ? 359  LYS A N    1 
ATOM   2567 C CA   . LYS A 1 179 ? -26.07153 3.03111   -1.96276  1.000 19.44314 ? 359  LYS A CA   1 
ATOM   2568 C C    . LYS A 1 179 ? -24.81131 3.38216   -1.16449  1.000 18.61725 ? 359  LYS A C    1 
ATOM   2569 O O    . LYS A 1 179 ? -23.69704 3.50382   -1.69454  1.000 16.48771 ? 359  LYS A O    1 
ATOM   2570 C CB   . LYS A 1 179 ? -26.16412 1.51752   -2.21586  1.000 20.37365 ? 359  LYS A CB   1 
ATOM   2571 C CG   . LYS A 1 179 ? -26.01015 0.63744   -1.01651  1.000 26.13042 ? 359  LYS A CG   1 
ATOM   2572 C CD   . LYS A 1 179 ? -26.10040 -0.86412  -1.33001  1.000 30.49467 ? 359  LYS A CD   1 
ATOM   2573 C CE   . LYS A 1 179 ? -25.87286 -1.67166  -0.03894  1.000 26.13069 ? 359  LYS A CE   1 
ATOM   2574 H H    . LYS A 1 179 ? -25.99025 3.12955   -3.91087  1.000 20.67919 ? 359  LYS A H    1 
ATOM   2575 H HA   . LYS A 1 179 ? -26.81056 3.32566   -1.40780  1.000 23.33176 ? 359  LYS A HA   1 
ATOM   2576 H HB2  . LYS A 1 179 ? -27.03454 1.32781   -2.59964  1.000 24.44838 ? 359  LYS A HB2  1 
ATOM   2577 H HB3  . LYS A 1 179 ? -25.46493 1.27231   -2.84188  1.000 24.44838 ? 359  LYS A HB3  1 
ATOM   2578 H HG2  . LYS A 1 179 ? -25.14188 0.80332   -0.61715  1.000 31.35650 ? 359  LYS A HG2  1 
ATOM   2579 H HG3  . LYS A 1 179 ? -26.71291 0.84869   -0.38217  1.000 31.35650 ? 359  LYS A HG3  1 
ATOM   2580 H HD2  . LYS A 1 179 ? -26.97990 -1.07484  -1.68068  1.000 36.59361 ? 359  LYS A HD2  1 
ATOM   2581 H HD3  . LYS A 1 179 ? -25.41875 -1.10703  -1.97595  1.000 36.59361 ? 359  LYS A HD3  1 
ATOM   2582 N N    . PHE A 1 180 ? -24.97571 3.50382   0.14036   1.000 19.47414 ? 360  PHE A N    1 
ATOM   2583 C CA   . PHE A 1 180 ? -23.84301 3.78586   1.00872   1.000 19.54727 ? 360  PHE A CA   1 
ATOM   2584 C C    . PHE A 1 180 ? -22.69901 2.78750   0.80934   1.000 18.40671 ? 360  PHE A C    1 
ATOM   2585 O O    . PHE A 1 180 ? -22.90611 1.57505   0.85417   1.000 19.58111 ? 360  PHE A O    1 
ATOM   2586 C CB   . PHE A 1 180 ? -24.34767 3.69559   2.45106   1.000 22.54008 ? 360  PHE A CB   1 
ATOM   2587 C CG   . PHE A 1 180 ? -23.27281 3.86495   3.47880   1.000 20.02282 ? 360  PHE A CG   1 
ATOM   2588 C CD1  . PHE A 1 180 ? -22.74734 5.11804   3.75404   1.000 21.73978 ? 360  PHE A CD1  1 
ATOM   2589 C CD2  . PHE A 1 180 ? -22.78587 2.77896   4.18184   1.000 22.17410 ? 360  PHE A CD2  1 
ATOM   2590 C CE1  . PHE A 1 180 ? -21.74833 5.29491   4.71435   1.000 26.26057 ? 360  PHE A CE1  1 
ATOM   2591 C CE2  . PHE A 1 180 ? -21.78938 2.93815   5.15081   1.000 23.94345 ? 360  PHE A CE2  1 
ATOM   2592 C CZ   . PHE A 1 180 ? -21.27054 4.18652   5.42014   1.000 24.76871 ? 360  PHE A CZ   1 
ATOM   2593 H H    . PHE A 1 180 ? -25.72873 3.42835   0.54885   1.000 23.36897 ? 360  PHE A H    1 
ATOM   2594 H HA   . PHE A 1 180 ? -23.48881 4.66724   0.81225   1.000 23.45673 ? 360  PHE A HA   1 
ATOM   2595 H HB2  . PHE A 1 180 ? -25.00692 4.39246   2.59483   1.000 27.04810 ? 360  PHE A HB2  1 
ATOM   2596 H HB3  . PHE A 1 180 ? -24.75141 2.82400   2.58606   1.000 27.04810 ? 360  PHE A HB3  1 
ATOM   2597 H HD1  . PHE A 1 180 ? -23.06703 5.85728   3.28905   1.000 26.08773 ? 360  PHE A HD1  1 
ATOM   2598 H HD2  . PHE A 1 180 ? -23.12538 1.93072   4.00830   1.000 26.60892 ? 360  PHE A HD2  1 
ATOM   2599 H HE1  . PHE A 1 180 ? -21.40413 6.14231   4.88270   1.000 31.51268 ? 360  PHE A HE1  1 
ATOM   2600 H HE2  . PHE A 1 180 ? -21.47496 2.19694   5.61625   1.000 28.73214 ? 360  PHE A HE2  1 
ATOM   2601 H HZ   . PHE A 1 180 ? -20.60885 4.29055   6.06530   1.000 29.72245 ? 360  PHE A HZ   1 
ATOM   2602 N N    . ASP A 1 181 ? -21.48583 3.31201   0.62170   1.000 17.09984 ? 361  ASP A N    1 
ATOM   2603 C CA   . ASP A 1 181 ? -20.26059 2.48580   0.54406   1.000 16.72351 ? 361  ASP A CA   1 
ATOM   2604 C C    . ASP A 1 181 ? -20.18152 1.65596   -0.71758  1.000 17.22705 ? 361  ASP A C    1 
ATOM   2605 O O    . ASP A 1 181 ? -19.47520 0.65791   -0.75701  1.000 19.15835 ? 361  ASP A O    1 
ATOM   2606 C CB   . ASP A 1 181 ? -20.10229 1.63231   1.81604   1.000 18.18567 ? 361  ASP A CB   1 
ATOM   2607 C CG   . ASP A 1 181 ? -18.66903 1.18500   2.05514   1.000 17.55871 ? 361  ASP A CG   1 
ATOM   2608 O OD1  . ASP A 1 181 ? -17.71114 1.83354   1.56912   1.000 18.69229 ? 361  ASP A OD1  1 
ATOM   2609 O OD2  . ASP A 1 181 ? -18.50683 0.17788   2.76855   1.000 18.98245 ? 361  ASP A OD2  1 
ATOM   2610 H H    . ASP A 1 181 ? -21.33843 4.15480   0.53464   1.000 20.51980 ? 361  ASP A H    1 
ATOM   2611 H HA   . ASP A 1 181 ? -19.48900 3.07199   0.50023   1.000 20.06821 ? 361  ASP A HA   1 
ATOM   2612 H HB2  . ASP A 1 181 ? -20.38468 2.15434   2.58327   1.000 21.82280 ? 361  ASP A HB2  1 
ATOM   2613 H HB3  . ASP A 1 181 ? -20.65363 0.83848   1.73380   1.000 21.82280 ? 361  ASP A HB3  1 
ATOM   2614 N N    . ARG A 1 182 ? -20.88982 2.05751   -1.76311  1.000 16.36929 ? 362  ARG A N    1 
ATOM   2615 C CA   . ARG A 1 182 ? -20.85128 1.37652   -3.05234  1.000 15.68020 ? 362  ARG A CA   1 
ATOM   2616 C C    . ARG A 1 182 ? -19.83883 2.06142   -3.95031  1.000 15.13180 ? 362  ARG A C    1 
ATOM   2617 O O    . ARG A 1 182 ? -19.84439 3.28779   -4.09856  1.000 15.45602 ? 362  ARG A O    1 
ATOM   2618 C CB   . ARG A 1 182 ? -22.23258 1.41489   -3.70776  1.000 17.33894 ? 362  ARG A CB   1 
ATOM   2619 C CG   . ARG A 1 182 ? -22.22176 1.02153   -5.17449  1.000 16.82078 ? 362  ARG A CG   1 
ATOM   2620 C CD   . ARG A 1 182 ? -23.63041 0.80377   -5.69429  1.000 17.89542 ? 362  ARG A CD   1 
ATOM   2621 N NE   . ARG A 1 182 ? -24.23191 -0.40023  -5.14562  1.000 18.59248 ? 362  ARG A NE   1 
ATOM   2622 C CZ   . ARG A 1 182 ? -25.43151 -0.85740  -5.48518  1.000 20.18751 ? 362  ARG A CZ   1 
ATOM   2623 N NH1  . ARG A 1 182 ? -26.22902 -0.16199  -6.27445  1.000 21.02476 ? 362  ARG A NH1  1 
ATOM   2624 N NH2  . ARG A 1 182 ? -25.81033 -2.06059  -5.06312  1.000 24.81232 ? 362  ARG A NH2  1 
ATOM   2625 H H    . ARG A 1 182 ? -21.41406 2.73916   -1.75185  1.000 19.64315 ? 362  ARG A H    1 
ATOM   2626 H HA   . ARG A 1 182 ? -20.58363 0.45206   -2.93139  1.000 18.81624 ? 362  ARG A HA   1 
ATOM   2627 H HB2  . ARG A 1 182 ? -22.81752 0.79872   -3.23969  1.000 20.80673 ? 362  ARG A HB2  1 
ATOM   2628 H HB3  . ARG A 1 182 ? -22.58292 2.31725   -3.64521  1.000 20.80673 ? 362  ARG A HB3  1 
ATOM   2629 H HG2  . ARG A 1 182 ? -21.80925 1.72854   -5.69494  1.000 20.18494 ? 362  ARG A HG2  1 
ATOM   2630 H HG3  . ARG A 1 182 ? -21.72424 0.19598   -5.28330  1.000 20.18494 ? 362  ARG A HG3  1 
ATOM   2631 H HD2  . ARG A 1 182 ? -24.18367 1.56019   -5.44403  1.000 21.47451 ? 362  ARG A HD2  1 
ATOM   2632 H HD3  . ARG A 1 182 ? -23.60457 0.71675   -6.66003  1.000 21.47451 ? 362  ARG A HD3  1 
ATOM   2633 H HE   . ARG A 1 182 ? -23.78184 -0.84532  -4.56344  1.000 22.31098 ? 362  ARG A HE   1 
ATOM   2634 H HH11 . ARG A 1 182 ? -25.97460 0.60131   -6.57817  1.000 25.22972 ? 362  ARG A HH11 1 
ATOM   2635 H HH12 . ARG A 1 182 ? -27.00300 -0.47224  -6.48492  1.000 25.22972 ? 362  ARG A HH12 1 
ATOM   2636 H HH21 . ARG A 1 182 ? -25.28063 -2.53207  -4.57658  1.000 29.77479 ? 362  ARG A HH21 1 
ATOM   2637 H HH22 . ARG A 1 182 ? -26.58496 -2.36703  -5.27678  1.000 29.77479 ? 362  ARG A HH22 1 
ATOM   2638 N N    . LEU A 1 183 ? -18.98010 1.28024   -4.57201  1.000 15.28464 ? 363  LEU A N    1 
ATOM   2639 C CA   . LEU A 1 183 ? -18.05393 1.74468   -5.59393  1.000 15.85483 ? 363  LEU A CA   1 
ATOM   2640 C C    . LEU A 1 183 ? -18.50854 1.21649   -6.94995  1.000 14.63777 ? 363  LEU A C    1 
ATOM   2641 O O    . LEU A 1 183 ? -18.88457 0.06116   -7.08356  1.000 16.24658 ? 363  LEU A O    1 
ATOM   2642 C CB   . LEU A 1 183 ? -16.64484 1.21175   -5.27864  1.000 16.83957 ? 363  LEU A CB   1 
ATOM   2643 C CG   . LEU A 1 183 ? -15.47508 1.69694   -6.14334  1.000 16.23980 ? 363  LEU A CG   1 
ATOM   2644 C CD1  . LEU A 1 183 ? -15.29161 3.15797   -5.79605  1.000 18.57120 ? 363  LEU A CD1  1 
ATOM   2645 C CD2  . LEU A 1 183 ? -14.22072 0.87363   -5.84354  1.000 17.96692 ? 363  LEU A CD2  1 
ATOM   2646 H H    . LEU A 1 183 ? -18.90838 0.43775   -4.41497  1.000 18.34157 ? 363  LEU A H    1 
ATOM   2647 H HA   . LEU A 1 183 ? -18.03087 2.71365   -5.63211  1.000 19.02580 ? 363  LEU A HA   1 
ATOM   2648 H HB2  . LEU A 1 183 ? -16.43529 1.45903   -4.36440  1.000 20.20749 ? 363  LEU A HB2  1 
ATOM   2649 H HB3  . LEU A 1 183 ? -16.67059 0.24581   -5.36347  1.000 20.20749 ? 363  LEU A HB3  1 
ATOM   2650 H HG   . LEU A 1 183 ? -15.63793 1.59377   -7.09399  1.000 19.48777 ? 363  LEU A HG   1 
ATOM   2651 H HD11 . LEU A 1 183 ? -14.50161 3.49324   -6.24815  1.000 22.28544 ? 363  LEU A HD11 1 
ATOM   2652 H HD12 . LEU A 1 183 ? -16.07392 3.65232   -6.08676  1.000 22.28544 ? 363  LEU A HD12 1 
ATOM   2653 H HD13 . LEU A 1 183 ? -15.18441 3.24327   -4.83578  1.000 22.28544 ? 363  LEU A HD13 1 
ATOM   2654 H HD21 . LEU A 1 183 ? -13.47330 1.24566   -6.33735  1.000 21.56030 ? 363  LEU A HD21 1 
ATOM   2655 H HD22 . LEU A 1 183 ? -14.03911 0.91014   -4.89140  1.000 21.56030 ? 363  LEU A HD22 1 
ATOM   2656 H HD23 . LEU A 1 183 ? -14.37308 -0.04469  -6.11625  1.000 21.56030 ? 363  LEU A HD23 1 
ATOM   2657 N N    . LEU A 1 184 ? -18.45270 2.07756   -7.96023  1.000 14.18977 ? 364  LEU A N    1 
ATOM   2658 C CA   . LEU A 1 184 ? -18.90905 1.77296   -9.30016  1.000 13.32495 ? 364  LEU A CA   1 
ATOM   2659 C C    . LEU A 1 184 ? -17.82509 2.14453   -10.30423 1.000 14.51570 ? 364  LEU A C    1 
ATOM   2660 O O    . LEU A 1 184 ? -17.24528 3.22051   -10.21090 1.000 14.54905 ? 364  LEU A O    1 
ATOM   2661 C CB   . LEU A 1 184 ? -20.18583 2.60715   -9.60303  1.000 15.31481 ? 364  LEU A CB   1 
ATOM   2662 C CG   . LEU A 1 184 ? -20.68732 2.65901   -11.03915 1.000 15.54260 ? 364  LEU A CG   1 
ATOM   2663 C CD1  . LEU A 1 184 ? -21.20822 1.30687   -11.45986 1.000 17.78396 ? 364  LEU A CD1  1 
ATOM   2664 C CD2  . LEU A 1 184 ? -21.81284 3.69086   -11.24811 1.000 16.59119 ? 364  LEU A CD2  1 
ATOM   2665 H H    . LEU A 1 184 ? -18.14096 2.87561   -7.88580  1.000 17.02773 ? 364  LEU A H    1 
ATOM   2666 H HA   . LEU A 1 184 ? -19.09446 0.82528   -9.39193  1.000 15.98994 ? 364  LEU A HA   1 
ATOM   2667 H HB2  . LEU A 1 184 ? -20.90882 2.24171   -9.06951  1.000 18.37777 ? 364  LEU A HB2  1 
ATOM   2668 H HB3  . LEU A 1 184 ? -20.00798 3.52309   -9.33781  1.000 18.37777 ? 364  LEU A HB3  1 
ATOM   2669 H HG   . LEU A 1 184 ? -19.93210 2.92443   -11.58696 1.000 18.65112 ? 364  LEU A HG   1 
ATOM   2670 H HD11 . LEU A 1 184 ? -21.51829 1.35943   -12.37746 1.000 21.34076 ? 364  LEU A HD11 1 
ATOM   2671 H HD12 . LEU A 1 184 ? -20.49191 0.65661   -11.38948 1.000 21.34076 ? 364  LEU A HD12 1 
ATOM   2672 H HD13 . LEU A 1 184 ? -21.94156 1.05557   -10.87679 1.000 21.34076 ? 364  LEU A HD13 1 
ATOM   2673 H HD21 . LEU A 1 184 ? -22.12341 3.63800   -12.16553 1.000 19.90943 ? 364  LEU A HD21 1 
ATOM   2674 H HD22 . LEU A 1 184 ? -22.54166 3.49068   -10.64012 1.000 19.90943 ? 364  LEU A HD22 1 
ATOM   2675 H HD23 . LEU A 1 184 ? -21.46536 4.57822   -11.06714 1.000 19.90943 ? 364  LEU A HD23 1 
ATOM   2676 N N    . PHE A 1 185 ? -17.60074 1.27634   -11.27285 1.000 14.03580 ? 365  PHE A N    1 
ATOM   2677 C CA   . PHE A 1 185 ? -16.78337 1.62852   -12.43865 1.000 13.47572 ? 365  PHE A CA   1 
ATOM   2678 C C    . PHE A 1 185 ? -17.60200 1.38813   -13.70111 1.000 13.94462 ? 365  PHE A C    1 
ATOM   2679 O O    . PHE A 1 185 ? -18.40783 0.45522   -13.77646 1.000 14.47848 ? 365  PHE A O    1 
ATOM   2680 C CB   . PHE A 1 185 ? -15.58336 0.70477   -12.57933 1.000 14.70558 ? 365  PHE A CB   1 
ATOM   2681 C CG   . PHE A 1 185 ? -14.63412 0.66599   -11.41959 1.000 14.61952 ? 365  PHE A CG   1 
ATOM   2682 C CD1  . PHE A 1 185 ? -14.86002 -0.18056  -10.35679 1.000 14.92130 ? 365  PHE A CD1  1 
ATOM   2683 C CD2  . PHE A 1 185 ? -13.49530 1.45541   -11.40809 1.000 16.59822 ? 365  PHE A CD2  1 
ATOM   2684 C CE1  . PHE A 1 185 ? -13.97266 -0.26897  -9.31067  1.000 16.42086 ? 365  PHE A CE1  1 
ATOM   2685 C CE2  . PHE A 1 185 ? -12.59044 1.38881   -10.35971 1.000 18.23169 ? 365  PHE A CE2  1 
ATOM   2686 C CZ   . PHE A 1 185 ? -12.82513 0.51942   -9.30369  1.000 18.63488 ? 365  PHE A CZ   1 
ATOM   2687 H H    . PHE A 1 185 ? -17.90819 0.47326   -11.28516 1.000 16.84296 ? 365  PHE A H    1 
ATOM   2688 H HA   . PHE A 1 185 ? -16.50298 2.55262   -12.34747 1.000 16.17086 ? 365  PHE A HA   1 
ATOM   2689 H HB2  . PHE A 1 185 ? -15.91156 -0.19872  -12.70924 1.000 17.64670 ? 365  PHE A HB2  1 
ATOM   2690 H HB3  . PHE A 1 185 ? -15.07414 0.98750   -13.35500 1.000 17.64670 ? 365  PHE A HB3  1 
ATOM   2691 H HD1  . PHE A 1 185 ? -15.62911 -0.70335  -10.34675 1.000 17.90556 ? 365  PHE A HD1  1 
ATOM   2692 H HD2  . PHE A 1 185 ? -13.33550 2.03886   -12.11445 1.000 19.91786 ? 365  PHE A HD2  1 
ATOM   2693 H HE1  . PHE A 1 185 ? -14.13875 -0.85508  -8.60796  1.000 19.70503 ? 365  PHE A HE1  1 
ATOM   2694 H HE2  . PHE A 1 185 ? -11.82995 1.92411   -10.36412 1.000 21.87803 ? 365  PHE A HE2  1 
ATOM   2695 H HZ   . PHE A 1 185 ? -12.22171 0.46399   -8.59820  1.000 22.36186 ? 365  PHE A HZ   1 
ATOM   2696 N N    . PHE A 1 186 ? -17.37988 2.22340   -14.71977 1.000 14.09686 ? 366  PHE A N    1 
ATOM   2697 C CA   . PHE A 1 186 ? -17.95544 1.96486   -16.04613 1.000 13.65783 ? 366  PHE A CA   1 
ATOM   2698 C C    . PHE A 1 186 ? -17.13735 2.66670   -17.12243 1.000 14.03381 ? 366  PHE A C    1 
ATOM   2699 O O    . PHE A 1 186 ? -16.48759 3.68555   -16.86382 1.000 12.76445 ? 366  PHE A O    1 
ATOM   2700 C CB   . PHE A 1 186 ? -19.46500 2.32119   -16.12876 1.000 13.92068 ? 366  PHE A CB   1 
ATOM   2701 C CG   . PHE A 1 186 ? -19.83056 3.75542   -15.85281 1.000 14.12157 ? 366  PHE A CG   1 
ATOM   2702 C CD1  . PHE A 1 186 ? -19.84363 4.68414   -16.89002 1.000 15.19740 ? 366  PHE A CD1  1 
ATOM   2703 C CD2  . PHE A 1 186 ? -20.20287 4.17941   -14.58097 1.000 14.89342 ? 366  PHE A CD2  1 
ATOM   2704 C CE1  . PHE A 1 186 ? -20.21763 5.99054   -16.68868 1.000 15.70212 ? 366  PHE A CE1  1 
ATOM   2705 C CE2  . PHE A 1 186 ? -20.57841 5.50208   -14.35742 1.000 14.73630 ? 366  PHE A CE2  1 
ATOM   2706 C CZ   . PHE A 1 186 ? -20.56685 6.41909   -15.39966 1.000 14.53096 ? 366  PHE A CZ   1 
ATOM   2707 H H    . PHE A 1 186 ? -16.90512 2.93879   -14.67056 1.000 16.91623 ? 366  PHE A H    1 
ATOM   2708 H HA   . PHE A 1 186 ? -17.88607 1.01426   -16.22625 1.000 16.38939 ? 366  PHE A HA   1 
ATOM   2709 H HB2  . PHE A 1 186 ? -19.77471 2.11583   -17.02476 1.000 16.70481 ? 366  PHE A HB2  1 
ATOM   2710 H HB3  . PHE A 1 186 ? -19.93924 1.77685   -15.48092 1.000 16.70481 ? 366  PHE A HB3  1 
ATOM   2711 H HD1  . PHE A 1 186 ? -19.59210 4.41241   -17.74314 1.000 18.23688 ? 366  PHE A HD1  1 
ATOM   2712 H HD2  . PHE A 1 186 ? -20.20100 3.57480   -13.87433 1.000 17.87211 ? 366  PHE A HD2  1 
ATOM   2713 H HE1  . PHE A 1 186 ? -20.23912 6.58669   -17.40215 1.000 18.84254 ? 366  PHE A HE1  1 
ATOM   2714 H HE2  . PHE A 1 186 ? -20.83802 5.77203   -13.50617 1.000 17.68356 ? 366  PHE A HE2  1 
ATOM   2715 H HZ   . PHE A 1 186 ? -20.78850 7.30889   -15.24465 1.000 17.43716 ? 366  PHE A HZ   1 
ATOM   2716 N N    . TRP A 1 187 ? -17.13767 2.10307   -18.33048 1.000 13.42069 ? 367  TRP A N    1 
ATOM   2717 C CA   . TRP A 1 187 ? -16.47042 2.79426   -19.42795 1.000 12.86291 ? 367  TRP A CA   1 
ATOM   2718 C C    . TRP A 1 187 ? -17.11116 4.16818   -19.63606 1.000 13.38572 ? 367  TRP A C    1 
ATOM   2719 O O    . TRP A 1 187 ? -18.33726 4.28871   -19.75039 1.000 14.39115 ? 367  TRP A O    1 
ATOM   2720 C CB   . TRP A 1 187 ? -16.57333 2.03903   -20.74285 1.000 14.14408 ? 367  TRP A CB   1 
ATOM   2721 C CG   . TRP A 1 187 ? -16.08096 0.63681   -20.78028 1.000 14.28720 ? 367  TRP A CG   1 
ATOM   2722 C CD1  . TRP A 1 187 ? -16.74442 -0.41707  -21.32465 1.000 14.83115 ? 367  TRP A CD1  1 
ATOM   2723 C CD2  . TRP A 1 187 ? -14.80427 0.13263   -20.37966 1.000 13.81169 ? 367  TRP A CD2  1 
ATOM   2724 N NE1  . TRP A 1 187 ? -16.00197 -1.54324  -21.24255 1.000 16.28436 ? 367  TRP A NE1  1 
ATOM   2725 C CE2  . TRP A 1 187 ? -14.79473 -1.24545  -20.67382 1.000 14.95312 ? 367  TRP A CE2  1 
ATOM   2726 C CE3  . TRP A 1 187 ? -13.67019 0.70206   -19.80080 1.000 15.85577 ? 367  TRP A CE3  1 
ATOM   2727 C CZ2  . TRP A 1 187 ? -13.71231 -2.05541  -20.39670 1.000 17.64439 ? 367  TRP A CZ2  1 
ATOM   2728 C CZ3  . TRP A 1 187 ? -12.60116 -0.10573  -19.50720 1.000 17.75731 ? 367  TRP A CZ3  1 
ATOM   2729 C CH2  . TRP A 1 187 ? -12.62150 -1.47808  -19.82100 1.000 18.50667 ? 367  TRP A CH2  1 
ATOM   2730 H H    . TRP A 1 187 ? -17.50306 1.35090   -18.53128 1.000 16.10482 ? 367  TRP A H    1 
ATOM   2731 H HA   . TRP A 1 187 ? -15.53222 2.86830   -19.19300 1.000 15.43550 ? 367  TRP A HA   1 
ATOM   2732 H HB2  . TRP A 1 187 ? -17.50937 2.01189   -20.99582 1.000 16.97289 ? 367  TRP A HB2  1 
ATOM   2733 H HB3  . TRP A 1 187 ? -16.06439 2.53023   -21.40663 1.000 16.97289 ? 367  TRP A HB3  1 
ATOM   2734 H HD1  . TRP A 1 187 ? -17.59312 -0.36968  -21.70198 1.000 17.79738 ? 367  TRP A HD1  1 
ATOM   2735 H HE1  . TRP A 1 187 ? -16.24955 -2.32350  -21.50621 1.000 19.54124 ? 367  TRP A HE1  1 
ATOM   2736 H HE3  . TRP A 1 187 ? -13.63937 1.61323   -19.61715 1.000 19.02692 ? 367  TRP A HE3  1 
ATOM   2737 H HZ2  . TRP A 1 187 ? -13.72725 -2.96366  -20.59611 1.000 21.17327 ? 367  TRP A HZ2  1 
ATOM   2738 H HZ3  . TRP A 1 187 ? -11.85155 0.25862   -19.09460 1.000 21.30877 ? 367  TRP A HZ3  1 
ATOM   2739 H HH2  . TRP A 1 187 ? -11.87570 -2.00035  -19.63150 1.000 22.20801 ? 367  TRP A HH2  1 
ATOM   2740 N N    . SER A 1 188 ? -16.27902 5.20093   -19.75474 1.000 14.68365 ? 368  SER A N    1 
ATOM   2741 C CA   . SER A 1 188 ? -16.77772 6.56755   -19.86876 1.000 13.70635 ? 368  SER A CA   1 
ATOM   2742 C C    . SER A 1 188 ? -17.28022 6.93881   -21.25170 1.000 14.01117 ? 368  SER A C    1 
ATOM   2743 O O    . SER A 1 188 ? -17.89837 7.99531   -21.37996 1.000 13.61650 ? 368  SER A O    1 
ATOM   2744 C CB   . SER A 1 188 ? -15.65942 7.55094   -19.54112 1.000 12.80306 ? 368  SER A CB   1 
ATOM   2745 O OG   . SER A 1 188 ? -15.03034 7.26229   -18.31421 1.000 13.81329 ? 368  SER A OG   1 
ATOM   2746 H H    . SER A 1 188 ? -15.42167 5.13566   -19.77170 1.000 17.62037 ? 368  SER A H    1 
ATOM   2747 H HA   . SER A 1 188 ? -17.50963 6.65137   -19.23774 1.000 16.44762 ? 368  SER A HA   1 
ATOM   2748 H HB2  . SER A 1 188 ? -14.99489 7.50961   -20.24652 1.000 15.36367 ? 368  SER A HB2  1 
ATOM   2749 H HB3  . SER A 1 188 ? -16.03675 8.44323   -19.49267 1.000 15.36367 ? 368  SER A HB3  1 
ATOM   2750 H HG   . SER A 1 188 ? -15.60810 7.14072   -17.71671 1.000 16.57595 ? 368  SER A HG   1 
ATOM   2751 N N    . ASP A 1 189 ? -16.96452 6.16207   -22.27854 1.000 14.21211 ? 369  ASP A N    1 
ATOM   2752 C CA   . ASP A 1 189 ? -17.28570 6.53098   -23.65306 1.000 14.63077 ? 369  ASP A CA   1 
ATOM   2753 C C    . ASP A 1 189 ? -18.74431 6.21520   -24.00218 1.000 16.22101 ? 369  ASP A C    1 
ATOM   2754 O O    . ASP A 1 189 ? -19.57347 5.96320   -23.11981 1.000 15.97971 ? 369  ASP A O    1 
ATOM   2755 C CB   . ASP A 1 189 ? -16.25324 5.91344   -24.60552 1.000 14.52396 ? 369  ASP A CB   1 
ATOM   2756 C CG   . ASP A 1 189 ? -16.37383 4.40445   -24.74593 1.000 19.22741 ? 369  ASP A CG   1 
ATOM   2757 O OD1  . ASP A 1 189 ? -17.38111 3.80622   -24.32778 1.000 17.33856 ? 369  ASP A OD1  1 
ATOM   2758 O OD2  . ASP A 1 189 ? -15.40626 3.79181   -25.29572 1.000 19.11982 ? 369  ASP A OD2  1 
ATOM   2759 H H    . ASP A 1 189 ? -16.55922 5.40698   -22.20658 1.000 17.05453 ? 369  ASP A H    1 
ATOM   2760 H HA   . ASP A 1 189 ? -17.21930 7.49590   -23.72670 1.000 17.55692 ? 369  ASP A HA   1 
ATOM   2761 H HB2  . ASP A 1 189 ? -16.36940 6.30244   -25.48648 1.000 17.42875 ? 369  ASP A HB2  1 
ATOM   2762 H HB3  . ASP A 1 189 ? -15.36394 6.10900   -24.27114 1.000 17.42875 ? 369  ASP A HB3  1 
ATOM   2763 N N    . ARG A 1 190 ? -19.07813 6.29878   -25.29768 1.000 16.68035 ? 370  ARG A N    1 
ATOM   2764 C CA   . ARG A 1 190 ? -20.46394 6.16108   -25.75075 1.000 17.88352 ? 370  ARG A CA   1 
ATOM   2765 C C    . ARG A 1 190 ? -21.05875 4.77815   -25.49632 1.000 18.14628 ? 370  ARG A C    1 
ATOM   2766 O O    . ARG A 1 190 ? -22.26296 4.60798   -25.69851 1.000 18.16606 ? 370  ARG A O    1 
ATOM   2767 C CB   . ARG A 1 190 ? -20.57392 6.41487   -27.26077 1.000 20.90204 ? 370  ARG A CB   1 
ATOM   2768 C CG   . ARG A 1 190 ? -20.47850 7.86327   -27.64664 1.000 24.19499 ? 370  ARG A CG   1 
ATOM   2769 C CD   . ARG A 1 190 ? -20.15867 7.96820   -29.12280 1.000 30.89683 ? 370  ARG A CD   1 
ATOM   2770 N NE   . ARG A 1 190 ? -21.07570 8.84432   -29.83306 1.000 48.78921 ? 370  ARG A NE   1 
ATOM   2771 C CZ   . ARG A 1 190 ? -20.66610 9.91578   -30.48426 1.000 39.25624 ? 370  ARG A CZ   1 
ATOM   2772 N NH1  . ARG A 1 190 ? -19.39425 10.27896  -30.47426 1.000 48.56207 ? 370  ARG A NH1  1 
ATOM   2773 N NH2  . ARG A 1 190 ? -21.55066 10.65614  -31.14805 1.000 53.31826 ? 370  ARG A NH2  1 
ATOM   2774 H H    . ARG A 1 190 ? -18.51682 6.43532   -25.93478 1.000 20.01642 ? 370  ARG A H    1 
ATOM   2775 H HA   . ARG A 1 190 ? -20.97430 6.82797   -25.26528 1.000 21.46022 ? 370  ARG A HA   1 
ATOM   2776 H HB2  . ARG A 1 190 ? -19.85462 5.94246   -27.70837 1.000 25.08245 ? 370  ARG A HB2  1 
ATOM   2777 H HB3  . ARG A 1 190 ? -21.43146 6.08324   -27.56987 1.000 25.08245 ? 370  ARG A HB3  1 
ATOM   2778 H HG2  . ARG A 1 190 ? -21.32454 8.30614   -27.47640 1.000 29.03398 ? 370  ARG A HG2  1 
ATOM   2779 H HG3  . ARG A 1 190 ? -19.77129 8.29322   -27.14079 1.000 29.03398 ? 370  ARG A HG3  1 
ATOM   2780 H HD2  . ARG A 1 190 ? -19.26208 8.32306   -29.22819 1.000 37.07619 ? 370  ARG A HD2  1 
ATOM   2781 H HD3  . ARG A 1 190 ? -20.21555 7.08630   -29.52269 1.000 37.07619 ? 370  ARG A HD3  1 
ATOM   2782 H HE   . ARG A 1 190 ? -21.91514 8.65743   -29.82853 1.000 58.54706 ? 370  ARG A HE   1 
ATOM   2783 H HH11 . ARG A 1 190 ? -18.81760 9.81360   -30.03778 1.000 58.27448 ? 370  ARG A HH11 1 
ATOM   2784 H HH12 . ARG A 1 190 ? -19.14398 10.98044  -30.90425 1.000 58.27448 ? 370  ARG A HH12 1 
ATOM   2785 H HH21 . ARG A 1 190 ? -22.38161 10.43453  -31.15003 1.000 63.98191 ? 370  ARG A HH21 1 
ATOM   2786 H HH22 . ARG A 1 190 ? -21.29130 11.35616  -31.57501 1.000 63.98191 ? 370  ARG A HH22 1 
ATOM   2787 N N    . ARG A 1 191 ? -20.27274 3.80251   -25.08425 1.000 16.17408 ? 371  ARG A N    1 
ATOM   2788 C CA   . ARG A 1 191 ? -20.88966 2.53136   -24.72368 1.000 16.29213 ? 371  ARG A CA   1 
ATOM   2789 C C    . ARG A 1 191 ? -21.87342 2.64979   -23.55782 1.000 17.52571 ? 371  ARG A C    1 
ATOM   2790 O O    . ARG A 1 191 ? -22.77583 1.81468   -23.44482 1.000 17.64323 ? 371  ARG A O    1 
ATOM   2791 C CB   . ARG A 1 191 ? -19.82661 1.49691   -24.39743 1.000 16.45865 ? 371  ARG A CB   1 
ATOM   2792 C CG   . ARG A 1 191 ? -19.11194 0.98721   -25.62530 1.000 17.01420 ? 371  ARG A CG   1 
ATOM   2793 C CD   . ARG A 1 191 ? -17.92307 0.13360   -25.32192 1.000 19.32243 ? 371  ARG A CD   1 
ATOM   2794 N NE   . ARG A 1 191 ? -16.82258 0.87972   -24.74139 1.000 18.42360 ? 371  ARG A NE   1 
ATOM   2795 C CZ   . ARG A 1 191 ? -15.66167 0.34142   -24.40526 1.000 21.06884 ? 371  ARG A CZ   1 
ATOM   2796 N NH1  . ARG A 1 191 ? -15.45013 -0.96140  -24.52006 1.000 20.96183 ? 371  ARG A NH1  1 
ATOM   2797 N NH2  . ARG A 1 191 ? -14.68172 1.12015   -23.98532 1.000 20.93832 ? 371  ARG A NH2  1 
ATOM   2798 H H    . ARG A 1 191 ? -19.41728 3.84340   -25.00606 1.000 19.40889 ? 371  ARG A H    1 
ATOM   2799 H HA   . ARG A 1 191 ? -21.38814 2.21747   -25.49433 1.000 19.55055 ? 371  ARG A HA   1 
ATOM   2800 H HB2  . ARG A 1 191 ? -19.16651 1.89704   -23.81002 1.000 19.75037 ? 371  ARG A HB2  1 
ATOM   2801 H HB3  . ARG A 1 191 ? -20.24631 0.74057   -23.95845 1.000 19.75037 ? 371  ARG A HB3  1 
ATOM   2802 H HG2  . ARG A 1 191 ? -19.73129 0.45489   -26.14871 1.000 20.41704 ? 371  ARG A HG2  1 
ATOM   2803 H HG3  . ARG A 1 191 ? -18.80497 1.74615   -26.14557 1.000 20.41704 ? 371  ARG A HG3  1 
ATOM   2804 H HD2  . ARG A 1 191 ? -18.18259 -0.55559  -24.69060 1.000 23.18692 ? 371  ARG A HD2  1 
ATOM   2805 H HD3  . ARG A 1 191 ? -17.60783 -0.27192  -26.14476 1.000 23.18692 ? 371  ARG A HD3  1 
ATOM   2806 H HE   . ARG A 1 191 ? -16.93134 1.72228   -24.60777 1.000 22.10833 ? 371  ARG A HE   1 
ATOM   2807 H HH11 . ARG A 1 191 ? -16.07351 -1.47368  -24.81766 1.000 25.15420 ? 371  ARG A HH11 1 
ATOM   2808 H HH12 . ARG A 1 191 ? -14.68942 -1.29482  -24.29698 1.000 25.15420 ? 371  ARG A HH12 1 
ATOM   2809 H HH21 . ARG A 1 191 ? -14.80075 1.97020   -23.93199 1.000 25.12599 ? 371  ARG A HH21 1 
ATOM   2810 H HH22 . ARG A 1 191 ? -13.92436 0.77735   -23.76511 1.000 25.12599 ? 371  ARG A HH22 1 
ATOM   2811 N N    . ASN A 1 192 ? -21.73656 3.65903   -22.68871 1.000 14.97985 ? 372  ASN A N    1 
ATOM   2812 C CA   . ASN A 1 192 ? -22.52622 3.77264   -21.45178 1.000 14.69293 ? 372  ASN A CA   1 
ATOM   2813 C C    . ASN A 1 192 ? -23.19935 5.14550   -21.31438 1.000 16.17494 ? 372  ASN A C    1 
ATOM   2814 O O    . ASN A 1 192 ? -22.87883 5.92572   -20.39461 1.000 15.20016 ? 372  ASN A O    1 
ATOM   2815 C CB   . ASN A 1 192 ? -21.64905 3.49691   -20.23480 1.000 14.02749 ? 372  ASN A CB   1 
ATOM   2816 C CG   . ASN A 1 192 ? -21.26495 2.04047   -20.12521 1.000 15.70983 ? 372  ASN A CG   1 
ATOM   2817 O OD1  . ASN A 1 192 ? -22.10336 1.17012   -20.32426 1.000 15.84812 ? 372  ASN A OD1  1 
ATOM   2818 N ND2  . ASN A 1 192 ? -20.04779 1.77655   -19.73706 1.000 13.87856 ? 372  ASN A ND2  1 
ATOM   2819 H H    . ASN A 1 192 ? -21.17975 4.30566   -22.79563 1.000 17.97582 ? 372  ASN A H    1 
ATOM   2820 H HA   . ASN A 1 192 ? -23.24183 3.12063   -21.51254 1.000 17.63152 ? 372  ASN A HA   1 
ATOM   2821 H HB2  . ASN A 1 192 ? -20.83493 4.01964   -20.30449 1.000 16.83299 ? 372  ASN A HB2  1 
ATOM   2822 H HB3  . ASN A 1 192 ? -22.13348 3.74289   -19.43123 1.000 16.83299 ? 372  ASN A HB3  1 
ATOM   2823 H HD21 . ASN A 1 192 ? -19.50511 2.41891   -19.55686 1.000 16.65427 ? 372  ASN A HD21 1 
ATOM   2824 H HD22 . ASN A 1 192 ? -19.78808 0.96021   -19.66137 1.000 16.65427 ? 372  ASN A HD22 1 
ATOM   2825 N N    . PRO A 1 193 ? -24.17465 5.45970   -22.16597 1.000 14.02543 ? 373  PRO A N    1 
ATOM   2826 C CA   . PRO A 1 193 ? -25.04881 6.57720   -21.84121 1.000 13.24159 ? 373  PRO A CA   1 
ATOM   2827 C C    . PRO A 1 193 ? -25.71900 6.33641   -20.49020 1.000 14.63417 ? 373  PRO A C    1 
ATOM   2828 O O    . PRO A 1 193 ? -25.96912 5.19563   -20.09762 1.000 15.77779 ? 373  PRO A O    1 
ATOM   2829 C CB   . PRO A 1 193 ? -26.07359 6.59037   -22.99246 1.000 15.84223 ? 373  PRO A CB   1 
ATOM   2830 C CG   . PRO A 1 193 ? -25.46635 5.66355   -24.05346 1.000 16.93242 ? 373  PRO A CG   1 
ATOM   2831 C CD   . PRO A 1 193 ? -24.61021 4.70401   -23.35651 1.000 14.33532 ? 373  PRO A CD   1 
ATOM   2832 H HA   . PRO A 1 193 ? -24.56907 7.42026   -21.83903 1.000 15.88991 ? 373  PRO A HA   1 
ATOM   2833 H HB2  . PRO A 1 193 ? -26.92796 6.25263   -22.68120 1.000 19.01068 ? 373  PRO A HB2  1 
ATOM   2834 H HB3  . PRO A 1 193 ? -26.17801 7.49200   -23.33460 1.000 19.01068 ? 373  PRO A HB3  1 
ATOM   2835 H HG2  . PRO A 1 193 ? -26.17914 5.20211   -24.52240 1.000 20.31891 ? 373  PRO A HG2  1 
ATOM   2836 H HG3  . PRO A 1 193 ? -24.94438 6.19020   -24.67883 1.000 20.31891 ? 373  PRO A HG3  1 
ATOM   2837 H HD2  . PRO A 1 193 ? -25.11078 3.91316   -23.10178 1.000 17.20238 ? 373  PRO A HD2  1 
ATOM   2838 H HD3  . PRO A 1 193 ? -23.85089 4.45343   -23.90564 1.000 17.20238 ? 373  PRO A HD3  1 
ATOM   2839 N N    . HIS A 1 194 ? -25.99417 7.41945   -19.75234 1.000 16.11154 ? 374  HIS A N    1 
ATOM   2840 C CA   . HIS A 1 194 ? -26.54297 7.24963   -18.41280 1.000 15.48227 ? 374  HIS A CA   1 
ATOM   2841 C C    . HIS A 1 194 ? -27.25241 8.52827   -18.00010 1.000 13.08324 ? 374  HIS A C    1 
ATOM   2842 O O    . HIS A 1 194 ? -26.98229 9.61012   -18.49496 1.000 15.09074 ? 374  HIS A O    1 
ATOM   2843 C CB   . HIS A 1 194 ? -25.48593 6.83474   -17.37458 1.000 16.02567 ? 374  HIS A CB   1 
ATOM   2844 C CG   . HIS A 1 194 ? -24.28065 7.72927   -17.35004 1.000 13.97647 ? 374  HIS A CG   1 
ATOM   2845 N ND1  . HIS A 1 194 ? -23.27017 7.61214   -18.27701 1.000 14.82223 ? 374  HIS A ND1  1 
ATOM   2846 C CD2  . HIS A 1 194 ? -23.91564 8.74990   -16.53292 1.000 14.75556 ? 374  HIS A CD2  1 
ATOM   2847 C CE1  . HIS A 1 194 ? -22.34244 8.52510   -18.04070 1.000 15.65426 ? 374  HIS A CE1  1 
ATOM   2848 N NE2  . HIS A 1 194 ? -22.71455 9.23264   -17.00149 1.000 14.79978 ? 374  HIS A NE2  1 
ATOM   2849 H H    . HIS A 1 194 ? -25.87397 8.23369   -20.00166 1.000 19.33385 ? 374  HIS A H    1 
ATOM   2850 H HA   . HIS A 1 194 ? -27.20041 6.53705   -18.44287 1.000 18.57873 ? 374  HIS A HA   1 
ATOM   2851 H HB2  . HIS A 1 194 ? -25.88922 6.85671   -16.49266 1.000 19.23081 ? 374  HIS A HB2  1 
ATOM   2852 H HB3  . HIS A 1 194 ? -25.18374 5.93594   -17.57889 1.000 19.23081 ? 374  HIS A HB3  1 
ATOM   2853 H HD1  . HIS A 1 194 ? -23.24559 7.03366   -18.91290 1.000 17.78668 ? 374  HIS A HD1  1 
ATOM   2854 H HD2  . HIS A 1 194 ? -24.38781 9.06379   -15.79574 1.000 17.70667 ? 374  HIS A HD2  1 
ATOM   2855 H HE1  . HIS A 1 194 ? -21.55974 8.64467   -18.52853 1.000 18.78512 ? 374  HIS A HE1  1 
ATOM   2856 N N    . GLU A 1 195 ? -28.20807 8.36690   -17.09295 1.000 15.40449 ? 375  GLU A N    1 
ATOM   2857 C CA   . GLU A 1 195 ? -28.95131 9.47247   -16.51560 1.000 15.91923 ? 375  GLU A CA   1 
ATOM   2858 C C    . GLU A 1 195 ? -28.98150 9.31086   -15.00281 1.000 15.26706 ? 375  GLU A C    1 
ATOM   2859 O O    . GLU A 1 195 ? -29.02362 8.19940   -14.50023 1.000 17.06337 ? 375  GLU A O    1 
ATOM   2860 C CB   . GLU A 1 195 ? -30.38749 9.49165   -17.07439 1.000 20.02731 ? 375  GLU A CB   1 
ATOM   2861 C CG   . GLU A 1 195 ? -31.17303 8.25156   -16.73007 1.000 22.87632 ? 375  GLU A CG   1 
ATOM   2862 C CD   . GLU A 1 195 ? -32.39645 7.98409   -17.61905 1.000 29.20433 ? 375  GLU A CD   1 
ATOM   2863 O OE1  . GLU A 1 195 ? -32.40105 8.32297   -18.83295 1.000 29.61484 ? 375  GLU A OE1  1 
ATOM   2864 O OE2  . GLU A 1 195 ? -33.36094 7.36855   -17.10129 1.000 31.27174 ? 375  GLU A OE2  1 
ATOM   2865 H H    . GLU A 1 195 ? -28.44994 7.60011   -16.78777 1.000 18.48538 ? 375  GLU A H    1 
ATOM   2866 H HA   . GLU A 1 195 ? -28.52438 10.31909  -16.72021 1.000 19.10308 ? 375  GLU A HA   1 
ATOM   2867 H HB2  . GLU A 1 195 ? -30.85804 10.25553  -16.70565 1.000 24.03277 ? 375  GLU A HB2  1 
ATOM   2868 H HB3  . GLU A 1 195 ? -30.34773 9.56148   -18.04105 1.000 24.03277 ? 375  GLU A HB3  1 
ATOM   2869 H HG2  . GLU A 1 195 ? -30.58479 7.48431   -16.80880 1.000 27.45158 ? 375  GLU A HG2  1 
ATOM   2870 H HG3  . GLU A 1 195 ? -31.49092 8.33360   -15.81731 1.000 27.45158 ? 375  GLU A HG3  1 
ATOM   2871 N N    . VAL A 1 196 ? -28.92788 10.43366  -14.28357 1.000 15.29459 ? 376  VAL A N    1 
ATOM   2872 C CA   . VAL A 1 196 ? -29.26964 10.46203  -12.86416 1.000 15.70978 ? 376  VAL A CA   1 
ATOM   2873 C C    . VAL A 1 196 ? -30.73839 10.85645  -12.75496 1.000 16.06463 ? 376  VAL A C    1 
ATOM   2874 O O    . VAL A 1 196 ? -31.12986 11.99118  -13.07152 1.000 16.24763 ? 376  VAL A O    1 
ATOM   2875 C CB   . VAL A 1 196 ? -28.36718 11.38609  -12.03963 1.000 15.02169 ? 376  VAL A CB   1 
ATOM   2876 C CG1  . VAL A 1 196 ? -28.82505 11.44692  -10.55511 1.000 17.13786 ? 376  VAL A CG1  1 
ATOM   2877 C CG2  . VAL A 1 196 ? -26.88500 10.96605  -12.16553 1.000 15.64332 ? 376  VAL A CG2  1 
ATOM   2878 H H    . VAL A 1 196 ? -28.69378 11.19785  -14.60107 1.000 18.35351 ? 376  VAL A H    1 
ATOM   2879 H HA   . VAL A 1 196 ? -29.15765 9.56796   -12.50499 1.000 18.85174 ? 376  VAL A HA   1 
ATOM   2880 H HB   . VAL A 1 196 ? -28.44372 12.28547  -12.39483 1.000 18.02603 ? 376  VAL A HB   1 
ATOM   2881 H HG11 . VAL A 1 196 ? -28.15429 11.91846  -10.03681 1.000 20.56543 ? 376  VAL A HG11 1 
ATOM   2882 H HG12 . VAL A 1 196 ? -29.67231 11.91653  -10.50493 1.000 20.56543 ? 376  VAL A HG12 1 
ATOM   2883 H HG13 . VAL A 1 196 ? -28.92757 10.54282  -10.21895 1.000 20.56543 ? 376  VAL A HG13 1 
ATOM   2884 H HG21 . VAL A 1 196 ? -26.33575 11.59357  -11.67010 1.000 18.77198 ? 376  VAL A HG21 1 
ATOM   2885 H HG22 . VAL A 1 196 ? -26.77771 10.07340  -11.80145 1.000 18.77198 ? 376  VAL A HG22 1 
ATOM   2886 H HG23 . VAL A 1 196 ? -26.63305 10.97374  -13.10221 1.000 18.77198 ? 376  VAL A HG23 1 
ATOM   2887 N N    . GLN A 1 197 ? -31.54756 9.89625   -12.32731 1.000 16.56629 ? 377  GLN A N    1 
ATOM   2888 C CA   . GLN A 1 197 ? -32.98205 10.12624  -12.23742 1.000 16.12696 ? 377  GLN A CA   1 
ATOM   2889 C C    . GLN A 1 197 ? -33.27025 11.07162  -11.07662 1.000 17.45706 ? 377  GLN A C    1 
ATOM   2890 O O    . GLN A 1 197 ? -32.48042 11.15408  -10.13448 1.000 16.47687 ? 377  GLN A O    1 
ATOM   2891 C CB   . GLN A 1 197 ? -33.72563 8.81390   -12.05319 1.000 20.30123 ? 377  GLN A CB   1 
ATOM   2892 C CG   . GLN A 1 197 ? -33.47366 7.87918   -13.17906 1.000 19.48582 ? 377  GLN A CG   1 
ATOM   2893 C CD   . GLN A 1 197 ? -34.34220 6.64502   -13.14461 1.000 22.93767 ? 377  GLN A CD   1 
ATOM   2894 O OE1  . GLN A 1 197 ? -34.74671 6.18089   -12.08143 1.000 25.25755 ? 377  GLN A OE1  1 
ATOM   2895 N NE2  . GLN A 1 197 ? -34.69291 6.12940   -14.32627 1.000 27.58897 ? 377  GLN A NE2  1 
ATOM   2896 H H    . GLN A 1 197 ? -31.29384 9.11086   -12.08566 1.000 19.87955 ? 377  GLN A H    1 
ATOM   2897 H HA   . GLN A 1 197 ? -33.30835 10.52919  -13.05721 1.000 19.35236 ? 377  GLN A HA   1 
ATOM   2898 H HB2  . GLN A 1 197 ? -33.42865 8.39032   -11.23266 1.000 24.36148 ? 377  GLN A HB2  1 
ATOM   2899 H HB3  . GLN A 1 197 ? -34.67862 8.98946   -12.00983 1.000 24.36148 ? 377  GLN A HB3  1 
ATOM   2900 H HG2  . GLN A 1 197 ? -33.64760 8.34096   -14.01416 1.000 23.38299 ? 377  GLN A HG2  1 
ATOM   2901 H HG3  . GLN A 1 197 ? -32.54796 7.59132   -13.14569 1.000 23.38299 ? 377  GLN A HG3  1 
ATOM   2902 H HE21 . GLN A 1 197 ? -34.42441 6.50055   -15.05411 1.000 33.10677 ? 377  GLN A HE21 1 
ATOM   2903 H HE22 . GLN A 1 197 ? -35.18714 5.42636   -14.35901 1.000 33.10677 ? 377  GLN A HE22 1 
ATOM   2904 N N    . PRO A 1 198 ? -34.39715 11.80284  -11.13409 1.000 19.51044 ? 378  PRO A N    1 
ATOM   2905 C CA   . PRO A 1 198 ? -34.64252 12.85770  -10.15083 1.000 20.01407 ? 378  PRO A CA   1 
ATOM   2906 C C    . PRO A 1 198 ? -34.49162 12.36114  -8.73324  1.000 21.13664 ? 378  PRO A C    1 
ATOM   2907 O O    . PRO A 1 198 ? -35.01184 11.29876  -8.36680  1.000 20.60242 ? 378  PRO A O    1 
ATOM   2908 C CB   . PRO A 1 198 ? -36.08004 13.27988  -10.45193 1.000 22.23899 ? 378  PRO A CB   1 
ATOM   2909 C CG   . PRO A 1 198 ? -36.22345 13.02763  -11.90188 1.000 26.05511 ? 378  PRO A CG   1 
ATOM   2910 C CD   . PRO A 1 198 ? -35.41172 11.82663  -12.21635 1.000 21.65118 ? 378  PRO A CD   1 
ATOM   2911 H HA   . PRO A 1 198 ? -34.03646 13.60165  -10.29273 1.000 24.01689 ? 378  PRO A HA   1 
ATOM   2912 H HB2  . PRO A 1 198 ? -36.70220 12.74160  -9.93803  1.000 26.68678 ? 378  PRO A HB2  1 
ATOM   2913 H HB3  . PRO A 1 198 ? -36.20407 14.21925  -10.24436 1.000 26.68678 ? 378  PRO A HB3  1 
ATOM   2914 H HG2  . PRO A 1 198 ? -37.15747 12.86995  -12.11078 1.000 31.26613 ? 378  PRO A HG2  1 
ATOM   2915 H HG3  . PRO A 1 198 ? -35.89801 13.79600  -12.39644 1.000 31.26613 ? 378  PRO A HG3  1 
ATOM   2916 H HD2  . PRO A 1 198 ? -35.95836 11.02565  -12.19397 1.000 25.98141 ? 378  PRO A HD2  1 
ATOM   2917 H HD3  . PRO A 1 198 ? -34.98775 11.91480  -13.08432 1.000 25.98141 ? 378  PRO A HD3  1 
ATOM   2918 N N    . ALA A 1 199 ? -33.81189 13.17016  -7.92613  1.000 21.65297 ? 379  ALA A N    1 
ATOM   2919 C CA   . ALA A 1 199 ? -33.56387 12.91068  -6.50769  1.000 17.75903 ? 379  ALA A CA   1 
ATOM   2920 C C    . ALA A 1 199 ? -34.46596 13.78255  -5.65230  1.000 18.71639 ? 379  ALA A C    1 
ATOM   2921 O O    . ALA A 1 199 ? -34.56309 15.00128  -5.87006  1.000 20.14068 ? 379  ALA A O    1 
ATOM   2922 C CB   . ALA A 1 199 ? -32.10072 13.23026  -6.17409  1.000 19.86808 ? 379  ALA A CB   1 
ATOM   2923 H H    . ALA A 1 199 ? -33.46673 13.91280  -8.18870  1.000 25.98357 ? 379  ALA A H    1 
ATOM   2924 H HA   . ALA A 1 199 ? -33.75975 11.98165  -6.30914  1.000 21.31083 ? 379  ALA A HA   1 
ATOM   2925 H HB1  . ALA A 1 199 ? -31.94633 13.05653  -5.23235  1.000 23.84170 ? 379  ALA A HB1  1 
ATOM   2926 H HB2  . ALA A 1 199 ? -31.52362 12.66713  -6.71329  1.000 23.84170 ? 379  ALA A HB2  1 
ATOM   2927 H HB3  . ALA A 1 199 ? -31.92878 14.16445  -6.37065  1.000 23.84170 ? 379  ALA A HB3  1 
ATOM   2928 N N    . TYR A 1 200 ? -35.06040 13.19394  -4.62712  1.000 19.47077 ? 380  TYR A N    1 
ATOM   2929 C CA   . TYR A 1 200 ? -35.99391 13.89131  -3.75349  1.000 19.91608 ? 380  TYR A CA   1 
ATOM   2930 C C    . TYR A 1 200 ? -35.46393 14.04517  -2.33294  1.000 22.02437 ? 380  TYR A C    1 
ATOM   2931 O O    . TYR A 1 200 ? -36.17905 14.55289  -1.45617  1.000 26.38197 ? 380  TYR A O    1 
ATOM   2932 C CB   . TYR A 1 200 ? -37.37358 13.20011  -3.78678  1.000 23.69542 ? 380  TYR A CB   1 
ATOM   2933 C CG   . TYR A 1 200 ? -37.86753 13.12935  -5.22130  1.000 25.27939 ? 380  TYR A CG   1 
ATOM   2934 C CD1  . TYR A 1 200 ? -38.29252 14.28819  -5.86707  1.000 29.06217 ? 380  TYR A CD1  1 
ATOM   2935 C CD2  . TYR A 1 200 ? -37.92871 11.93160  -5.90357  1.000 28.60753 ? 380  TYR A CD2  1 
ATOM   2936 C CE1  . TYR A 1 200 ? -38.71708 14.26387  -7.16776  1.000 30.66823 ? 380  TYR A CE1  1 
ATOM   2937 C CE2  . TYR A 1 200 ? -38.37608 11.88732  -7.21353  1.000 30.51422 ? 380  TYR A CE2  1 
ATOM   2938 C CZ   . TYR A 1 200 ? -38.77306 13.06951  -7.83360  1.000 25.53147 ? 380  TYR A CZ   1 
ATOM   2939 O OH   . TYR A 1 200 ? -39.21113 12.99891  -9.14611  1.000 43.01492 ? 380  TYR A OH   1 
ATOM   2940 H H    . TYR A 1 200 ? -34.93737 12.37086  -4.41030  1.000 23.36492 ? 380  TYR A H    1 
ATOM   2941 H HA   . TYR A 1 200 ? -36.14076 14.79055  -4.08621  1.000 23.89930 ? 380  TYR A HA   1 
ATOM   2942 H HB2  . TYR A 1 200 ? -37.29831 12.29916  -3.43533  1.000 28.43451 ? 380  TYR A HB2  1 
ATOM   2943 H HB3  . TYR A 1 200 ? -38.00916 13.70963  -3.26014  1.000 28.43451 ? 380  TYR A HB3  1 
ATOM   2944 H HD1  . TYR A 1 200 ? -38.28760 15.09508  -5.40467  1.000 34.87460 ? 380  TYR A HD1  1 
ATOM   2945 H HD2  . TYR A 1 200 ? -37.66695 11.14632  -5.47963  1.000 34.32904 ? 380  TYR A HD2  1 
ATOM   2946 H HE1  . TYR A 1 200 ? -38.96527 15.05161  -7.59527  1.000 36.80188 ? 380  TYR A HE1  1 
ATOM   2947 H HE2  . TYR A 1 200 ? -38.41093 11.07936  -7.67275  1.000 36.61707 ? 380  TYR A HE2  1 
ATOM   2948 H HH   . TYR A 1 200 ? -39.18117 12.20423  -9.41664  1.000 51.61790 ? 380  TYR A HH   1 
ATOM   2949 N N    . ALA A 1 201 ? -34.22665 13.60946  -2.09393  1.000 23.67869 ? 381  ALA A N    1 
ATOM   2950 C CA   . ALA A 1 201 ? -33.49406 13.92142  -0.88060  1.000 22.42168 ? 381  ALA A CA   1 
ATOM   2951 C C    . ALA A 1 201 ? -32.05721 14.24253  -1.28516  1.000 21.58316 ? 381  ALA A C    1 
ATOM   2952 O O    . ALA A 1 201 ? -31.64108 14.01261  -2.42190  1.000 21.92788 ? 381  ALA A O    1 
ATOM   2953 C CB   . ALA A 1 201 ? -33.55473 12.78769  0.15140   1.000 25.44985 ? 381  ALA A CB   1 
ATOM   2954 H H    . ALA A 1 201 ? -33.78149 13.11649  -2.64020  1.000 28.41443 ? 381  ALA A H    1 
ATOM   2955 H HA   . ALA A 1 201 ? -33.88106 14.69944  -0.44954  1.000 26.90601 ? 381  ALA A HA   1 
ATOM   2956 H HB1  . ALA A 1 201 ? -33.06371 13.05544  0.94393   1.000 30.53983 ? 381  ALA A HB1  1 
ATOM   2957 H HB2  . ALA A 1 201 ? -34.48211 12.61694  0.37881   1.000 30.53983 ? 381  ALA A HB2  1 
ATOM   2958 H HB3  . ALA A 1 201 ? -33.15584 11.99061  -0.23129  1.000 30.53983 ? 381  ALA A HB3  1 
ATOM   2959 N N    . THR A 1 202 ? -31.28955 14.75807  -0.33770  1.000 22.05939 ? 382  THR A N    1 
ATOM   2960 C CA   . THR A 1 202 ? -29.91448 15.16954  -0.60113  1.000 22.21600 ? 382  THR A CA   1 
ATOM   2961 C C    . THR A 1 202 ? -29.06896 13.94350  -0.89752  1.000 20.15554 ? 382  THR A C    1 
ATOM   2962 O O    . THR A 1 202 ? -28.94953 13.03992  -0.05964  1.000 20.32360 ? 382  THR A O    1 
ATOM   2963 C CB   . THR A 1 202 ? -29.36724 15.89339  0.62423   1.000 25.29110 ? 382  THR A CB   1 
ATOM   2964 O OG1  . THR A 1 202 ? -30.19844 16.98601  0.95748   1.000 26.82519 ? 382  THR A OG1  1 
ATOM   2965 C CG2  . THR A 1 202 ? -27.93958 16.36961  0.37021   1.000 22.94918 ? 382  THR A CG2  1 
ATOM   2966 H H    . THR A 1 202 ? -31.54070 14.88268  0.47532   1.000 26.47127 ? 382  THR A H    1 
ATOM   2967 H HA   . THR A 1 202 ? -29.88454 15.76483  -1.36640  1.000 26.65921 ? 382  THR A HA   1 
ATOM   2968 H HB   . THR A 1 202 ? -29.34862 15.28345  1.37824   1.000 30.34933 ? 382  THR A HB   1 
ATOM   2969 H HG1  . THR A 1 202 ? -29.90600 17.37031  1.64479   1.000 32.19022 ? 382  THR A HG1  1 
ATOM   2970 H HG21 . THR A 1 202 ? -27.64265 16.93301  1.10186   1.000 27.53902 ? 382  THR A HG21 1 
ATOM   2971 H HG22 . THR A 1 202 ? -27.34365 15.60770  0.29770   1.000 27.53902 ? 382  THR A HG22 1 
ATOM   2972 H HG23 . THR A 1 202 ? -27.90147 16.87868  -0.45460  1.000 27.53902 ? 382  THR A HG23 1 
ATOM   2973 N N    . ARG A 1 203 ? -28.43856 13.92992  -2.07146  1.000 16.91144 ? 383  ARG A N    1 
ATOM   2974 C CA   . ARG A 1 203 ? -27.73107 12.78049  -2.60792  1.000 16.49149 ? 383  ARG A CA   1 
ATOM   2975 C C    . ARG A 1 203 ? -26.28287 13.15973  -2.88664  1.000 17.18031 ? 383  ARG A C    1 
ATOM   2976 O O    . ARG A 1 203 ? -26.03409 14.12889  -3.60987  1.000 18.61690 ? 383  ARG A O    1 
ATOM   2977 C CB   . ARG A 1 203 ? -28.41426 12.37258  -3.92009  1.000 16.11317 ? 383  ARG A CB   1 
ATOM   2978 C CG   . ARG A 1 203 ? -27.78249 11.16544  -4.63308  1.000 15.68852 ? 383  ARG A CG   1 
ATOM   2979 C CD   . ARG A 1 203 ? -28.26541 11.09955  -6.04774  1.000 17.40431 ? 383  ARG A CD   1 
ATOM   2980 N NE   . ARG A 1 203 ? -27.93870 9.89753   -6.83875  1.000 15.90287 ? 383  ARG A NE   1 
ATOM   2981 C CZ   . ARG A 1 203 ? -26.85012 9.76537   -7.57850  1.000 15.44294 ? 383  ARG A CZ   1 
ATOM   2982 N NH1  . ARG A 1 203 ? -25.83686 10.59489  -7.47600  1.000 14.88862 ? 383  ARG A NH1  1 
ATOM   2983 N NH2  . ARG A 1 203 ? -26.78077 8.76631   -8.45136  1.000 16.18559 ? 383  ARG A NH2  1 
ATOM   2984 H H    . ARG A 1 203 ? -28.40835 14.61023  -2.59668  1.000 20.29373 ? 383  ARG A H    1 
ATOM   2985 H HA   . ARG A 1 203 ? -27.72805 12.04552  -1.97490  1.000 19.78979 ? 383  ARG A HA   1 
ATOM   2986 H HB2  . ARG A 1 203 ? -29.33778 12.14644  -3.72806  1.000 19.33580 ? 383  ARG A HB2  1 
ATOM   2987 H HB3  . ARG A 1 203 ? -28.37711 13.12416  -4.53218  1.000 19.33580 ? 383  ARG A HB3  1 
ATOM   2988 H HG2  . ARG A 1 203 ? -26.81677 11.25637  -4.63743  1.000 18.82622 ? 383  ARG A HG2  1 
ATOM   2989 H HG3  . ARG A 1 203 ? -28.03660 10.34700  -4.17867  1.000 18.82622 ? 383  ARG A HG3  1 
ATOM   2990 H HD2  . ARG A 1 203 ? -29.23300 11.16641  -6.03306  1.000 20.88518 ? 383  ARG A HD2  1 
ATOM   2991 H HD3  . ARG A 1 203 ? -27.88784 11.85532  -6.52434  1.000 20.88518 ? 383  ARG A HD3  1 
ATOM   2992 H HE   . ARG A 1 203 ? -28.49232 9.23977   -6.81743  1.000 19.08345 ? 383  ARG A HE   1 
ATOM   2993 H HH11 . ARG A 1 203 ? -25.86963 11.24659  -6.91580  1.000 17.86635 ? 383  ARG A HH11 1 
ATOM   2994 H HH12 . ARG A 1 203 ? -25.14067 10.48631  -7.96908  1.000 17.86635 ? 383  ARG A HH12 1 
ATOM   2995 H HH21 . ARG A 1 203 ? -27.43785 8.21697   -8.52924  1.000 19.42271 ? 383  ARG A HH21 1 
ATOM   2996 H HH22 . ARG A 1 203 ? -26.07880 8.66891   -8.93855  1.000 19.42271 ? 383  ARG A HH22 1 
ATOM   2997 N N    . TYR A 1 204 ? -25.35981 12.39412  -2.36302  1.000 16.72867 ? 384  TYR A N    1 
ATOM   2998 C CA   . TYR A 1 204 ? -23.93843 12.66565  -2.53989  1.000 15.34553 ? 384  TYR A CA   1 
ATOM   2999 C C    . TYR A 1 204 ? -23.21357 11.51657  -3.25365  1.000 16.94890 ? 384  TYR A C    1 
ATOM   3000 O O    . TYR A 1 204 ? -23.52187 10.32656  -3.05538  1.000 14.47116 ? 384  TYR A O    1 
ATOM   3001 C CB   . TYR A 1 204 ? -23.25413 12.79911  -1.18024  1.000 16.62624 ? 384  TYR A CB   1 
ATOM   3002 C CG   . TYR A 1 204 ? -23.71868 13.93479  -0.29051  1.000 17.20448 ? 384  TYR A CG   1 
ATOM   3003 C CD1  . TYR A 1 204 ? -23.54308 15.26906  -0.63616  1.000 17.94762 ? 384  TYR A CD1  1 
ATOM   3004 C CD2  . TYR A 1 204 ? -24.26858 13.67531  0.97093   1.000 18.41339 ? 384  TYR A CD2  1 
ATOM   3005 C CE1  . TYR A 1 204 ? -23.92822 16.30520  0.20868   1.000 19.57450 ? 384  TYR A CE1  1 
ATOM   3006 C CE2  . TYR A 1 204 ? -24.65414 14.71346  1.80884   1.000 18.41733 ? 384  TYR A CE2  1 
ATOM   3007 C CZ   . TYR A 1 204 ? -24.48871 16.03067  1.43726   1.000 19.92433 ? 384  TYR A CZ   1 
ATOM   3008 O OH   . TYR A 1 204 ? -24.87226 17.01935  2.27757   1.000 21.94387 ? 384  TYR A OH   1 
ATOM   3009 H H    . TYR A 1 204 ? -25.52511 11.69513  -1.89006  1.000 20.07440 ? 384  TYR A H    1 
ATOM   3010 H HA   . TYR A 1 204 ? -23.86288 13.47148  -3.07452  1.000 18.41464 ? 384  TYR A HA   1 
ATOM   3011 H HB2  . TYR A 1 204 ? -23.40079 11.97601  -0.68841  1.000 19.95149 ? 384  TYR A HB2  1 
ATOM   3012 H HB3  . TYR A 1 204 ? -22.30521 12.92948  -1.33341  1.000 19.95149 ? 384  TYR A HB3  1 
ATOM   3013 H HD1  . TYR A 1 204 ? -23.15667 15.47563  -1.45648  1.000 21.53714 ? 384  TYR A HD1  1 
ATOM   3014 H HD2  . TYR A 1 204 ? -24.37711 12.79531  1.25151   1.000 22.09607 ? 384  TYR A HD2  1 
ATOM   3015 H HE1  . TYR A 1 204 ? -23.80673 17.18805  -0.05724  1.000 23.48940 ? 384  TYR A HE1  1 
ATOM   3016 H HE2  . TYR A 1 204 ? -25.03092 14.51645  2.63595   1.000 22.10080 ? 384  TYR A HE2  1 
ATOM   3017 H HH   . TYR A 1 204 ? -24.25132 17.57808  2.36622   1.000 26.33264 ? 384  TYR A HH   1 
ATOM   3018 N N    . ALA A 1 205 ? -22.19185 11.87794  -4.03228  1.000 15.30409 ? 385  ALA A N    1 
ATOM   3019 C CA   . ALA A 1 205 ? -21.33367 10.91992  -4.73999  1.000 13.89531 ? 385  ALA A CA   1 
ATOM   3020 C C    . ALA A 1 205 ? -20.00953 11.59660  -5.01489  1.000 14.64035 ? 385  ALA A C    1 
ATOM   3021 O O    . ALA A 1 205 ? -19.93758 12.82222  -5.14925  1.000 15.82482 ? 385  ALA A O    1 
ATOM   3022 C CB   . ALA A 1 205 ? -21.94937 10.39412  -6.02809  1.000 16.58652 ? 385  ALA A CB   1 
ATOM   3023 H H    . ALA A 1 205 ? -21.96654 12.69596  -4.17255  1.000 18.36491 ? 385  ALA A H    1 
ATOM   3024 H HA   . ALA A 1 205 ? -21.18847 10.14784  -4.17104  1.000 16.67437 ? 385  ALA A HA   1 
ATOM   3025 H HB1  . ALA A 1 205 ? -21.35910 9.72615   -6.41057  1.000 19.90383 ? 385  ALA A HB1  1 
ATOM   3026 H HB2  . ALA A 1 205 ? -22.81149 9.99756   -5.82713  1.000 19.90383 ? 385  ALA A HB2  1 
ATOM   3027 H HB3  . ALA A 1 205 ? -22.06091 11.13124  -6.64866  1.000 19.90383 ? 385  ALA A HB3  1 
ATOM   3028 N N    . ILE A 1 206 ? -18.94931 10.80797  -5.04885  1.000 14.27222 ? 386  ILE A N    1 
ATOM   3029 C CA   . ILE A 1 206 ? -17.60251 11.28928  -5.34667  1.000 13.44023 ? 386  ILE A CA   1 
ATOM   3030 C C    . ILE A 1 206 ? -17.10255 10.53911  -6.56624  1.000 15.17076 ? 386  ILE A C    1 
ATOM   3031 O O    . ILE A 1 206 ? -17.01779 9.31083   -6.53069  1.000 14.20832 ? 386  ILE A O    1 
ATOM   3032 C CB   . ILE A 1 206 ? -16.65074 11.06793  -4.16917  1.000 14.38144 ? 386  ILE A CB   1 
ATOM   3033 C CG1  . ILE A 1 206 ? -17.17797 11.76964  -2.90963  1.000 14.16999 ? 386  ILE A CG1  1 
ATOM   3034 C CG2  . ILE A 1 206 ? -15.27070 11.54995  -4.58964  1.000 14.36077 ? 386  ILE A CG2  1 
ATOM   3035 C CD1  . ILE A 1 206 ? -16.32906 11.58094  -1.69612  1.000 18.20890 ? 386  ILE A CD1  1 
ATOM   3036 H H    . ILE A 1 206 ? -18.98139 9.96183   -4.89844  1.000 17.12667 ? 386  ILE A H    1 
ATOM   3037 H HA   . ILE A 1 206 ? -17.63916 12.23698  -5.55019  1.000 16.12827 ? 386  ILE A HA   1 
ATOM   3038 H HB   . ILE A 1 206 ? -16.59384 10.12716  -3.93980  1.000 17.25772 ? 386  ILE A HB   1 
ATOM   3039 H HG12 . ILE A 1 206 ? -17.23049 12.72213  -3.08539  1.000 17.00399 ? 386  ILE A HG12 1 
ATOM   3040 H HG13 . ILE A 1 206 ? -18.06007 11.42045  -2.70746  1.000 17.00399 ? 386  ILE A HG13 1 
ATOM   3041 H HG21 . ILE A 1 206 ? -14.69021 11.56233  -3.81261  1.000 17.23293 ? 386  ILE A HG21 1 
ATOM   3042 H HG22 . ILE A 1 206 ? -14.91495 10.94437  -5.25868  1.000 17.23293 ? 386  ILE A HG22 1 
ATOM   3043 H HG23 . ILE A 1 206 ? -15.34738 12.44338  -4.95951  1.000 17.23293 ? 386  ILE A HG23 1 
ATOM   3044 H HD11 . ILE A 1 206 ? -16.83534 11.84578  -0.91225  1.000 21.85068 ? 386  ILE A HD11 1 
ATOM   3045 H HD12 . ILE A 1 206 ? -16.07879 10.64626  -1.62801  1.000 21.85068 ? 386  ILE A HD12 1 
ATOM   3046 H HD13 . ILE A 1 206 ? -15.53434 12.13105  -1.77801  1.000 21.85068 ? 386  ILE A HD13 1 
ATOM   3047 N N    . SER A 1 207 ? -16.75256 11.28989  -7.63565  1.000 14.36435 ? 387  SER A N    1 
ATOM   3048 C CA   . SER A 1 207 ? -16.33666 10.68799  -8.90804  1.000 14.69269 ? 387  SER A CA   1 
ATOM   3049 C C    . SER A 1 207 ? -14.89018 11.04616  -9.23985  1.000 12.88292 ? 387  SER A C    1 
ATOM   3050 O O    . SER A 1 207 ? -14.45570 12.16899  -9.02054  1.000 14.48577 ? 387  SER A O    1 
ATOM   3051 C CB   . SER A 1 207 ? -17.21586 11.19766  -10.06459 1.000 15.75531 ? 387  SER A CB   1 
ATOM   3052 O OG   . SER A 1 207 ? -18.59544 10.86004  -9.93677  1.000 16.57587 ? 387  SER A OG   1 
ATOM   3053 H H    . SER A 1 207 ? -16.75080 12.14988  -7.64015  1.000 17.23722 ? 387  SER A H    1 
ATOM   3054 H HA   . SER A 1 207 ? -16.40797 9.72416   -8.82533  1.000 17.63123 ? 387  SER A HA   1 
ATOM   3055 H HB2  . SER A 1 207 ? -17.14229 12.16429  -10.09791 1.000 18.90637 ? 387  SER A HB2  1 
ATOM   3056 H HB3  . SER A 1 207 ? -16.88453 10.81106  -10.89021 1.000 18.90637 ? 387  SER A HB3  1 
ATOM   3057 H HG   . SER A 1 207 ? -19.04141 11.24130  -10.53790 1.000 19.89104 ? 387  SER A HG   1 
ATOM   3058 N N    . VAL A 1 208 ? -14.18392 10.10608  -9.85803  1.000 14.34263 ? 388  VAL A N    1 
ATOM   3059 C CA   . VAL A 1 208 ? -12.94077 10.41105  -10.55068 1.000 14.49960 ? 388  VAL A CA   1 
ATOM   3060 C C    . VAL A 1 208 ? -13.03680 9.80276   -11.94052 1.000 14.09891 ? 388  VAL A C    1 
ATOM   3061 O O    . VAL A 1 208 ? -13.73294 8.81777   -12.16720 1.000 15.60075 ? 388  VAL A O    1 
ATOM   3062 C CB   . VAL A 1 208 ? -11.67233 9.89076   -9.85439  1.000 18.18660 ? 388  VAL A CB   1 
ATOM   3063 C CG1  . VAL A 1 208 ? -11.48379 10.50117  -8.47900  1.000 17.20285 ? 388  VAL A CG1  1 
ATOM   3064 C CG2  . VAL A 1 208 ? -11.69446 8.40627   -9.77165  1.000 23.39925 ? 388  VAL A CG2  1 
ATOM   3065 H H    . VAL A 1 208 ? -14.40794 9.27636   -9.88957  1.000 17.21116 ? 388  VAL A H    1 
ATOM   3066 H HA   . VAL A 1 208 ? -12.85656 11.37635  -10.59534 1.000 17.39952 ? 388  VAL A HA   1 
ATOM   3067 H HB   . VAL A 1 208 ? -10.90997 10.16054  -10.39006 1.000 21.82392 ? 388  VAL A HB   1 
ATOM   3068 H HG11 . VAL A 1 208 ? -10.70628 10.10058  -8.05959  1.000 20.64341 ? 388  VAL A HG11 1 
ATOM   3069 H HG12 . VAL A 1 208 ? -11.35282 11.45765  -8.57323  1.000 20.64341 ? 388  VAL A HG12 1 
ATOM   3070 H HG13 . VAL A 1 208 ? -12.27448 10.32660  -7.94493  1.000 20.64341 ? 388  VAL A HG13 1 
ATOM   3071 H HG21 . VAL A 1 208 ? -10.95649 8.10990   -9.21625  1.000 28.07910 ? 388  VAL A HG21 1 
ATOM   3072 H HG22 . VAL A 1 208 ? -12.53640 8.12426   -9.38113  1.000 28.07910 ? 388  VAL A HG22 1 
ATOM   3073 H HG23 . VAL A 1 208 ? -11.60458 8.03882   -10.66485 1.000 28.07910 ? 388  VAL A HG23 1 
ATOM   3074 N N    . TRP A 1 209 ? -12.31101 10.36328  -12.88958 1.000 13.09513 ? 389  TRP A N    1 
ATOM   3075 C CA   . TRP A 1 209 ? -12.23043 9.75077   -14.20418 1.000 12.30250 ? 389  TRP A CA   1 
ATOM   3076 C C    . TRP A 1 209 ? -10.78015 9.43535   -14.51426 1.000 14.59094 ? 389  TRP A C    1 
ATOM   3077 O O    . TRP A 1 209 ? -9.91017  10.29387  -14.37774 1.000 14.56633 ? 389  TRP A O    1 
ATOM   3078 C CB   . TRP A 1 209 ? -12.76912 10.65534  -15.28094 1.000 13.65456 ? 389  TRP A CB   1 
ATOM   3079 C CG   . TRP A 1 209 ? -14.24417 10.88975  -15.26640 1.000 11.99177 ? 389  TRP A CG   1 
ATOM   3080 C CD1  . TRP A 1 209 ? -15.16644 10.14716  -15.90492 1.000 13.53786 ? 389  TRP A CD1  1 
ATOM   3081 C CD2  . TRP A 1 209 ? -14.94994 11.94701  -14.59676 1.000 14.36465 ? 389  TRP A CD2  1 
ATOM   3082 N NE1  . TRP A 1 209 ? -16.43683 10.68683  -15.70797 1.000 13.68838 ? 389  TRP A NE1  1 
ATOM   3083 C CE2  . TRP A 1 209 ? -16.31560 11.78031  -14.90215 1.000 12.83936 ? 389  TRP A CE2  1 
ATOM   3084 C CE3  . TRP A 1 209 ? -14.56381 13.01148  -13.79051 1.000 14.57504 ? 389  TRP A CE3  1 
ATOM   3085 C CZ2  . TRP A 1 209 ? -17.28998 12.66638  -14.44405 1.000 15.68866 ? 389  TRP A CZ2  1 
ATOM   3086 C CZ3  . TRP A 1 209 ? -15.54808 13.86954  -13.31134 1.000 16.29458 ? 389  TRP A CZ3  1 
ATOM   3087 C CH2  . TRP A 1 209 ? -16.88353 13.68833  -13.64055 1.000 18.65807 ? 389  TRP A CH2  1 
ATOM   3088 H H    . TRP A 1 209 ? -11.86088 11.09035  -12.79820 1.000 15.71415 ? 389  TRP A H    1 
ATOM   3089 H HA   . TRP A 1 209 ? -12.75158 8.93270   -14.19615 1.000 14.76300 ? 389  TRP A HA   1 
ATOM   3090 H HB2  . TRP A 1 209 ? -12.34129 11.52122  -15.19088 1.000 16.38548 ? 389  TRP A HB2  1 
ATOM   3091 H HB3  . TRP A 1 209 ? -12.55028 10.26508  -16.14159 1.000 16.38548 ? 389  TRP A HB3  1 
ATOM   3092 H HD1  . TRP A 1 209 ? -14.98327 9.38474   -16.40497 1.000 16.24543 ? 389  TRP A HD1  1 
ATOM   3093 H HE1  . TRP A 1 209 ? -17.17046 10.38256  -16.03781 1.000 16.42606 ? 389  TRP A HE1  1 
ATOM   3094 H HE3  . TRP A 1 209 ? -13.66889 13.14670  -13.57663 1.000 17.49004 ? 389  TRP A HE3  1 
ATOM   3095 H HZ2  . TRP A 1 209 ? -18.18405 12.56339  -14.67840 1.000 18.82639 ? 389  TRP A HZ2  1 
ATOM   3096 H HZ3  . TRP A 1 209 ? -15.30635 14.57822  -12.75976 1.000 19.55350 ? 389  TRP A HZ3  1 
ATOM   3097 H HH2  . TRP A 1 209 ? -17.51745 14.27976  -13.30401 1.000 22.38968 ? 389  TRP A HH2  1 
ATOM   3098 N N    . TYR A 1 210 ? -10.53365 8.19111   -14.88623 1.000 12.80186 ? 390  TYR A N    1 
ATOM   3099 C CA   . TYR A 1 210 ? -9.19483  7.69286   -15.25148 1.000 13.51347 ? 390  TYR A CA   1 
ATOM   3100 C C    . TYR A 1 210 ? -8.96811  7.92011   -16.74404 1.000 15.04301 ? 390  TYR A C    1 
ATOM   3101 O O    . TYR A 1 210 ? -9.86655  7.65714   -17.56048 1.000 16.95610 ? 390  TYR A O    1 
ATOM   3102 C CB   . TYR A 1 210 ? -9.03583  6.23380   -14.87471 1.000 15.56823 ? 390  TYR A CB   1 
ATOM   3103 C CG   . TYR A 1 210 ? -8.94800  6.09644   -13.36834 1.000 15.57659 ? 390  TYR A CG   1 
ATOM   3104 C CD1  . TYR A 1 210 ? -7.74548  6.23979   -12.72361 1.000 16.41872 ? 390  TYR A CD1  1 
ATOM   3105 C CD2  . TYR A 1 210 ? -10.09694 5.92135   -12.60764 1.000 16.38645 ? 390  TYR A CD2  1 
ATOM   3106 C CE1  . TYR A 1 210 ? -7.67228  6.18478   -11.32953 1.000 16.13594 ? 390  TYR A CE1  1 
ATOM   3107 C CE2  . TYR A 1 210 ? -10.01896 5.85491   -11.21101 1.000 17.24427 ? 390  TYR A CE2  1 
ATOM   3108 C CZ   . TYR A 1 210 ? -8.81253  5.99068   -10.60087 1.000 16.67567 ? 390  TYR A CZ   1 
ATOM   3109 O OH   . TYR A 1 210 ? -8.77263  5.93988   -9.22702  1.000 19.09134 ? 390  TYR A OH   1 
ATOM   3110 H H    . TYR A 1 210 ? -11.14042 7.58412   -14.94087 1.000 15.36224 ? 390  TYR A H    1 
ATOM   3111 H HA   . TYR A 1 210 ? -8.50761  8.17543   -14.76595 1.000 16.21616 ? 390  TYR A HA   1 
ATOM   3112 H HB2  . TYR A 1 210 ? -9.80217  5.72966   -15.19008 1.000 18.68188 ? 390  TYR A HB2  1 
ATOM   3113 H HB3  . TYR A 1 210 ? -8.22223  5.88164   -15.26834 1.000 18.68188 ? 390  TYR A HB3  1 
ATOM   3114 H HD1  . TYR A 1 210 ? -6.97070  6.37503   -13.21993 1.000 19.70246 ? 390  TYR A HD1  1 
ATOM   3115 H HD2  . TYR A 1 210 ? -10.92304 5.84779   -13.02841 1.000 19.66374 ? 390  TYR A HD2  1 
ATOM   3116 H HE1  . TYR A 1 210 ? -6.85293  6.27962   -10.89992 1.000 19.36313 ? 390  TYR A HE1  1 
ATOM   3117 H HE2  . TYR A 1 210 ? -10.78722 5.71887   -10.70487 1.000 20.69312 ? 390  TYR A HE2  1 
ATOM   3118 H HH   . TYR A 1 210 ? -7.98119  5.83382   -8.96632  1.000 22.90961 ? 390  TYR A HH   1 
ATOM   3119 N N    . PHE A 1 211 ? -7.76678  8.37201   -17.09532 1.000 14.92565 ? 391  PHE A N    1 
ATOM   3120 C CA   . PHE A 1 211 ? -7.36315  8.69660   -18.45564 1.000 14.43798 ? 391  PHE A CA   1 
ATOM   3121 C C    . PHE A 1 211 ? -6.61580  7.55329   -19.12845 1.000 18.60396 ? 391  PHE A C    1 
ATOM   3122 O O    . PHE A 1 211 ? -5.73437  6.91928   -18.53349 1.000 21.24312 ? 391  PHE A O    1 
ATOM   3123 C CB   . PHE A 1 211 ? -6.41216  9.89637   -18.42912 1.000 16.41924 ? 391  PHE A CB   1 
ATOM   3124 C CG   . PHE A 1 211 ? -7.05257  11.19876  -17.98790 1.000 14.21166 ? 391  PHE A CG   1 
ATOM   3125 C CD1  . PHE A 1 211 ? -8.20576  11.67587  -18.61855 1.000 16.30833 ? 391  PHE A CD1  1 
ATOM   3126 C CD2  . PHE A 1 211 ? -6.51810  11.91759  -16.94908 1.000 14.59372 ? 391  PHE A CD2  1 
ATOM   3127 C CE1  . PHE A 1 211 ? -8.79502  12.86694  -18.19711 1.000 17.84192 ? 391  PHE A CE1  1 
ATOM   3128 C CE2  . PHE A 1 211 ? -7.11172  13.10388  -16.54357 1.000 15.80018 ? 391  PHE A CE2  1 
ATOM   3129 C CZ   . PHE A 1 211 ? -8.21672  13.57366  -17.15384 1.000 14.59409 ? 391  PHE A CZ   1 
ATOM   3130 H H    . PHE A 1 211 ? -7.13358  8.50570   -16.52895 1.000 17.91078 ? 391  PHE A H    1 
ATOM   3131 H HA   . PHE A 1 211 ? -8.16583  8.87796   -18.96918 1.000 17.32558 ? 391  PHE A HA   1 
ATOM   3132 H HB2  . PHE A 1 211 ? -5.68812  9.70293   -17.81329 1.000 19.70309 ? 391  PHE A HB2  1 
ATOM   3133 H HB3  . PHE A 1 211 ? -6.06033  10.03133  -19.32294 1.000 19.70309 ? 391  PHE A HB3  1 
ATOM   3134 H HD1  . PHE A 1 211 ? -8.58107  11.19681  -19.32179 1.000 19.57000 ? 391  PHE A HD1  1 
ATOM   3135 H HD2  . PHE A 1 211 ? -5.75558  11.60873  -16.51541 1.000 17.51246 ? 391  PHE A HD2  1 
ATOM   3136 H HE1  . PHE A 1 211 ? -9.56581  13.18327  -18.61029 1.000 21.41030 ? 391  PHE A HE1  1 
ATOM   3137 H HE2  . PHE A 1 211 ? -6.74040  13.58305  -15.83829 1.000 18.96022 ? 391  PHE A HE2  1 
ATOM   3138 H HZ   . PHE A 1 211 ? -8.59382  14.37637  -16.87392 1.000 17.51290 ? 391  PHE A HZ   1 
ATOM   3139 N N    . ASP A 1 212 ? -6.91468  7.35425   -20.40871 1.000 17.86139 ? 392  ASP A N    1 
ATOM   3140 C CA   . ASP A 1 212 ? -6.04657  6.58825   -21.29953 1.000 19.81687 ? 392  ASP A CA   1 
ATOM   3141 C C    . ASP A 1 212 ? -4.92907  7.49783   -21.79044 1.000 17.96125 ? 392  ASP A C    1 
ATOM   3142 O O    . ASP A 1 212 ? -5.19196  8.60884   -22.26445 1.000 17.30385 ? 392  ASP A O    1 
ATOM   3143 C CB   . ASP A 1 212 ? -6.84254  6.07238   -22.50330 1.000 20.10139 ? 392  ASP A CB   1 
ATOM   3144 C CG   . ASP A 1 212 ? -5.95990  5.41467   -23.50884 1.000 20.22550 ? 392  ASP A CG   1 
ATOM   3145 O OD1  . ASP A 1 212 ? -5.41072  4.34906   -23.22553 1.000 24.24652 ? 392  ASP A OD1  1 
ATOM   3146 O OD2  . ASP A 1 212 ? -5.73282  6.00409   -24.59145 1.000 22.97472 ? 392  ASP A OD2  1 
ATOM   3147 H H    . ASP A 1 212 ? -7.62327  7.65583   -20.79151 1.000 21.43367 ? 392  ASP A H    1 
ATOM   3148 H HA   . ASP A 1 212 ? -5.67319  5.82786   -20.82700 1.000 23.78024 ? 392  ASP A HA   1 
ATOM   3149 H HB2  . ASP A 1 212 ? -7.49547  5.42220   -22.20022 1.000 24.12167 ? 392  ASP A HB2  1 
ATOM   3150 H HB3  . ASP A 1 212 ? -7.29103  6.81729   -22.93327 1.000 24.12167 ? 392  ASP A HB3  1 
ATOM   3151 N N    . ALA A 1 213 ? -3.69884  7.04017   -21.66277 1.000 19.88273 ? 393  ALA A N    1 
ATOM   3152 C CA   . ALA A 1 213 ? -2.55936  7.91940   -21.92831 1.000 19.48333 ? 393  ALA A CA   1 
ATOM   3153 C C    . ALA A 1 213 ? -2.60135  8.48143   -23.34098 1.000 19.82467 ? 393  ALA A C    1 
ATOM   3154 O O    . ALA A 1 213 ? -2.42435  9.68783   -23.54516 1.000 19.22481 ? 393  ALA A O    1 
ATOM   3155 C CB   . ALA A 1 213 ? -1.24593  7.17059   -21.71116 1.000 22.72239 ? 393  ALA A CB   1 
ATOM   3156 H H    . ALA A 1 213 ? -3.49103  6.23933   -21.42810 1.000 23.85927 ? 393  ALA A H    1 
ATOM   3157 H HA   . ALA A 1 213 ? -2.60319  8.65832   -21.30144 1.000 23.37999 ? 393  ALA A HA   1 
ATOM   3158 H HB1  . ALA A 1 213 ? -0.50622  7.77154   -21.89170 1.000 27.26687 ? 393  ALA A HB1  1 
ATOM   3159 H HB2  . ALA A 1 213 ? -1.20578  6.86341   -20.79196 1.000 27.26687 ? 393  ALA A HB2  1 
ATOM   3160 H HB3  . ALA A 1 213 ? -1.21110  6.41237   -22.31513 1.000 27.26687 ? 393  ALA A HB3  1 
ATOM   3161 N N    . ASP A 1 214 ? -2.79952  7.62427   -24.33591 1.000 20.83661 ? 394  ASP A N    1 
ATOM   3162 C CA   . ASP A 1 214 ? -2.66489  8.11260   -25.70506 1.000 20.93244 ? 394  ASP A CA   1 
ATOM   3163 C C    . ASP A 1 214 ? -3.83982  9.01619   -26.08400 1.000 18.68739 ? 394  ASP A C    1 
ATOM   3164 O O    . ASP A 1 214 ? -3.64414  10.05878  -26.72468 1.000 19.10932 ? 394  ASP A O    1 
ATOM   3165 C CB   . ASP A 1 214 ? -2.59862  6.94058   -26.66547 1.000 24.15293 ? 394  ASP A CB   1 
ATOM   3166 C CG   . ASP A 1 214 ? -1.27176  6.19018   -26.60776 1.000 35.77524 ? 394  ASP A CG   1 
ATOM   3167 O OD1  . ASP A 1 214 ? -0.28718  6.68483   -26.02881 1.000 30.26171 ? 394  ASP A OD1  1 
ATOM   3168 O OD2  . ASP A 1 214 ? -1.21638  5.10106   -27.19961 1.000 41.15894 ? 394  ASP A OD2  1 
ATOM   3169 H H    . ASP A 1 214 ? -3.00347  6.79311   -24.25123 1.000 25.00393 ? 394  ASP A H    1 
ATOM   3170 H HA   . ASP A 1 214 ? -1.84231  8.62205   -25.77384 1.000 25.11892 ? 394  ASP A HA   1 
ATOM   3171 H HB2  . ASP A 1 214 ? -3.30535  6.31363   -26.44556 1.000 28.98352 ? 394  ASP A HB2  1 
ATOM   3172 H HB3  . ASP A 1 214 ? -2.71617  7.26888   -27.57062 1.000 28.98352 ? 394  ASP A HB3  1 
ATOM   3173 N N    . GLU A 1 215 ? -5.05980  8.64881   -25.69219 1.000 17.81338 ? 395  GLU A N    1 
ATOM   3174 C CA   . GLU A 1 215 ? -6.19506  9.51058   -25.97698 1.000 21.25756 ? 395  GLU A CA   1 
ATOM   3175 C C    . GLU A 1 215 ? -6.06586  10.84895  -25.24995 1.000 17.50105 ? 395  GLU A C    1 
ATOM   3176 O O    . GLU A 1 215 ? -6.34228  11.91237  -25.83019 1.000 18.64384 ? 395  GLU A O    1 
ATOM   3177 C CB   . GLU A 1 215 ? -7.49261  8.82361   -25.57024 1.000 20.10931 ? 395  GLU A CB   1 
ATOM   3178 C CG   . GLU A 1 215 ? -8.69176  9.61259   -25.99406 1.000 19.98921 ? 395  GLU A CG   1 
ATOM   3179 C CD   . GLU A 1 215 ? -9.98600  8.98872   -25.51739 1.000 22.41247 ? 395  GLU A CD   1 
ATOM   3180 O OE1  . GLU A 1 215 ? -10.10704 7.75627   -25.65679 1.000 31.43698 ? 395  GLU A OE1  1 
ATOM   3181 O OE2  . GLU A 1 215 ? -10.85623 9.69330   -24.98158 1.000 19.72248 ? 395  GLU A OE2  1 
ATOM   3182 H H    . GLU A 1 215 ? -5.24874  7.92333   -25.27079 1.000 21.37606 ? 395  GLU A H    1 
ATOM   3183 H HA   . GLU A 1 215 ? -6.22358  9.67755   -26.93208 1.000 25.50907 ? 395  GLU A HA   1 
ATOM   3184 H HB2  . GLU A 1 215 ? -7.53774  7.95059   -25.99059 1.000 24.13117 ? 395  GLU A HB2  1 
ATOM   3185 H HB3  . GLU A 1 215 ? -7.51543  8.72873   -24.60516 1.000 24.13117 ? 395  GLU A HB3  1 
ATOM   3186 H HG2  . GLU A 1 215 ? -8.63219  10.50638  -25.62192 1.000 23.98706 ? 395  GLU A HG2  1 
ATOM   3187 H HG3  . GLU A 1 215 ? -8.71682  9.65752   -26.96270 1.000 23.98706 ? 395  GLU A HG3  1 
ATOM   3188 N N    . ARG A 1 216 ? -5.64828  10.83696  -23.98640 1.000 14.88432 ? 396  ARG A N    1 
ATOM   3189 C CA   . ARG A 1 216 ? -5.50713  12.07365  -23.22988 1.000 13.94198 ? 396  ARG A CA   1 
ATOM   3190 C C    . ARG A 1 216 ? -4.42960  12.95721  -23.84244 1.000 18.54705 ? 396  ARG A C    1 
ATOM   3191 O O    . ARG A 1 216 ? -4.58778  14.16895  -23.90114 1.000 16.02895 ? 396  ARG A O    1 
ATOM   3192 C CB   . ARG A 1 216 ? -5.21175  11.77827  -21.75904 1.000 18.66977 ? 396  ARG A CB   1 
ATOM   3193 C CG   . ARG A 1 216 ? -5.19435  12.99768  -20.82420 1.000 17.24169 ? 396  ARG A CG   1 
ATOM   3194 C CD   . ARG A 1 216 ? -6.47344  13.81306  -20.91830 1.000 15.36236 ? 396  ARG A CD   1 
ATOM   3195 N NE   . ARG A 1 216 ? -6.47131  14.86958  -19.90583 1.000 18.72899 ? 396  ARG A NE   1 
ATOM   3196 C CZ   . ARG A 1 216 ? -7.40365  15.80756  -19.80896 1.000 16.73287 ? 396  ARG A CZ   1 
ATOM   3197 N NH1  . ARG A 1 216 ? -8.41334  15.85149  -20.65392 1.000 18.18337 ? 396  ARG A NH1  1 
ATOM   3198 N NH2  . ARG A 1 216 ? -7.32223  16.70943  -18.82358 1.000 17.99801 ? 396  ARG A NH2  1 
ATOM   3199 H H    . ARG A 1 216 ? -5.44103  10.12798  -23.54595 1.000 17.86118 ? 396  ARG A H    1 
ATOM   3200 H HA   . ARG A 1 216 ? -6.34758  12.55724  -23.25610 1.000 16.73038 ? 396  ARG A HA   1 
ATOM   3201 H HB2  . ARG A 1 216 ? -5.89245  11.17168  -21.42800 1.000 22.40372 ? 396  ARG A HB2  1 
ATOM   3202 H HB3  . ARG A 1 216 ? -4.33850  11.35980  -21.70230 1.000 22.40372 ? 396  ARG A HB3  1 
ATOM   3203 H HG2  . ARG A 1 216 ? -5.09619  12.69508  -19.90785 1.000 20.69003 ? 396  ARG A HG2  1 
ATOM   3204 H HG3  . ARG A 1 216 ? -4.45142  13.57298  -21.06499 1.000 20.69003 ? 396  ARG A HG3  1 
ATOM   3205 H HD2  . ARG A 1 216 ? -6.53565  14.22282  -21.79529 1.000 18.43483 ? 396  ARG A HD2  1 
ATOM   3206 H HD3  . ARG A 1 216 ? -7.23936  13.23772  -20.76584 1.000 18.43483 ? 396  ARG A HD3  1 
ATOM   3207 H HE   . ARG A 1 216 ? -5.82525  14.88303  -19.33835 1.000 22.47478 ? 396  ARG A HE   1 
ATOM   3208 H HH11 . ARG A 1 216 ? -8.47530  15.26592  -21.28071 1.000 21.82004 ? 396  ARG A HH11 1 
ATOM   3209 H HH12 . ARG A 1 216 ? -9.01054  16.46574  -20.57874 1.000 21.82004 ? 396  ARG A HH12 1 
ATOM   3210 H HH21 . ARG A 1 216 ? -6.67095  16.67615  -18.26294 1.000 21.59762 ? 396  ARG A HH21 1 
ATOM   3211 H HH22 . ARG A 1 216 ? -7.92120  17.32226  -18.75100 1.000 21.59762 ? 396  ARG A HH22 1 
ATOM   3212 N N    . ALA A 1 217 ? -3.33367  12.36168  -24.32393 1.000 18.40066 ? 397  ALA A N    1 
ATOM   3213 C CA   . ALA A 1 217 ? -2.30789  13.13742  -25.01607 1.000 20.15290 ? 397  ALA A CA   1 
ATOM   3214 C C    . ALA A 1 217 ? -2.88642  13.80914  -26.25147 1.000 19.89932 ? 397  ALA A C    1 
ATOM   3215 O O    . ALA A 1 217 ? -2.66111  14.99753  -26.49318 1.000 18.78281 ? 397  ALA A O    1 
ATOM   3216 C CB   . ALA A 1 217 ? -1.13626  12.22933  -25.38651 1.000 18.44218 ? 397  ALA A CB   1 
ATOM   3217 H H    . ALA A 1 217 ? -3.16426  11.52075  -24.26272 1.000 22.08079 ? 397  ALA A H    1 
ATOM   3218 H HA   . ALA A 1 217 ? -1.97402  13.82990  -24.42454 1.000 24.18348 ? 397  ALA A HA   1 
ATOM   3219 H HB1  . ALA A 1 217 ? -0.44970  12.76041  -25.81951 1.000 22.13062 ? 397  ALA A HB1  1 
ATOM   3220 H HB2  . ALA A 1 217 ? -0.78192  11.82564  -24.57881 1.000 22.13062 ? 397  ALA A HB2  1 
ATOM   3221 H HB3  . ALA A 1 217 ? -1.45067  11.53886  -25.99091 1.000 22.13062 ? 397  ALA A HB3  1 
ATOM   3222 N N    . ARG A 1 218 ? -3.65254  13.06822  -27.05380 1.000 18.19289 ? 398  ARG A N    1 
ATOM   3223 C CA   . ARG A 1 218 ? -4.27478  13.70239  -28.22808 1.000 19.50850 ? 398  ARG A CA   1 
ATOM   3224 C C    . ARG A 1 218 ? -5.21600  14.85015  -27.83618 1.000 21.40872 ? 398  ARG A C    1 
ATOM   3225 O O    . ARG A 1 218 ? -5.22764  15.90949  -28.48382 1.000 19.83859 ? 398  ARG A O    1 
ATOM   3226 C CB   . ARG A 1 218 ? -5.01475  12.66932  -29.07776 1.000 21.25198 ? 398  ARG A CB   1 
ATOM   3227 C CG   . ARG A 1 218 ? -4.12518  11.66724  -29.79341 1.000 24.53480 ? 398  ARG A CG   1 
ATOM   3228 C CD   . ARG A 1 218 ? -4.89196  10.71684  -30.74276 1.000 28.20304 ? 398  ARG A CD   1 
ATOM   3229 N NE   . ARG A 1 218 ? -5.87755  9.88354   -30.06055 1.000 35.58146 ? 398  ARG A NE   1 
ATOM   3230 C CZ   . ARG A 1 218 ? -5.66734  8.64942   -29.61689 1.000 31.52774 ? 398  ARG A CZ   1 
ATOM   3231 N NH1  . ARG A 1 218 ? -4.48705  8.06475   -29.72410 1.000 36.58164 ? 398  ARG A NH1  1 
ATOM   3232 N NH2  . ARG A 1 218 ? -6.66680  7.99702   -29.03311 1.000 30.53725 ? 398  ARG A NH2  1 
ATOM   3233 H H    . ARG A 1 218 ? -3.82383  12.23192  -26.94961 1.000 21.83146 ? 398  ARG A H    1 
ATOM   3234 H HA   . ARG A 1 218 ? -3.56247  14.07691  -28.76961 1.000 23.41020 ? 398  ARG A HA   1 
ATOM   3235 H HB2  . ARG A 1 218 ? -5.61103  12.16767  -28.50010 1.000 25.50238 ? 398  ARG A HB2  1 
ATOM   3236 H HB3  . ARG A 1 218 ? -5.52629  13.13906  -29.75494 1.000 25.50238 ? 398  ARG A HB3  1 
ATOM   3237 H HG2  . ARG A 1 218 ? -3.47335  12.15139  -30.32409 1.000 29.44176 ? 398  ARG A HG2  1 
ATOM   3238 H HG3  . ARG A 1 218 ? -3.67385  11.12120  -29.13081 1.000 29.44176 ? 398  ARG A HG3  1 
ATOM   3239 H HD2  . ARG A 1 218 ? -5.36031  11.24728  -31.40622 1.000 33.84365 ? 398  ARG A HD2  1 
ATOM   3240 H HD3  . ARG A 1 218 ? -4.25572  10.12787  -31.17774 1.000 33.84365 ? 398  ARG A HD3  1 
ATOM   3241 H HE   . ARG A 1 218 ? -6.65922  10.21966  -29.93555 1.000 42.69775 ? 398  ARG A HE   1 
ATOM   3242 H HH11 . ARG A 1 218 ? -3.83085  8.48437   -30.08868 1.000 43.89797 ? 398  ARG A HH11 1 
ATOM   3243 H HH12 . ARG A 1 218 ? -4.37516  7.26464   -29.42930 1.000 43.89797 ? 398  ARG A HH12 1 
ATOM   3244 H HH21 . ARG A 1 218 ? -7.43479  8.37445   -28.94750 1.000 36.64471 ? 398  ARG A HH21 1 
ATOM   3245 H HH22 . ARG A 1 218 ? -6.54572  7.19732   -28.74086 1.000 36.64471 ? 398  ARG A HH22 1 
ATOM   3246 N N    . ALA A 1 219 ? -5.98020  14.67366  -26.76756 1.000 18.14105 ? 399  ALA A N    1 
ATOM   3247 C CA   . ALA A 1 219 ? -6.90930  15.70080  -26.31128 1.000 22.11243 ? 399  ALA A CA   1 
ATOM   3248 C C    . ALA A 1 219 ? -6.16075  16.92890  -25.82272 1.000 18.67373 ? 399  ALA A C    1 
ATOM   3249 O O    . ALA A 1 219 ? -6.54394  18.07373  -26.12856 1.000 21.93816 ? 399  ALA A O    1 
ATOM   3250 C CB   . ALA A 1 219 ? -7.77983  15.13438  -25.17864 1.000 20.04037 ? 399  ALA A CB   1 
ATOM   3251 H H    . ALA A 1 219 ? -5.98210  13.96321  -26.28293 1.000 21.76926 ? 399  ALA A H    1 
ATOM   3252 H HA   . ALA A 1 219 ? -7.48403  15.96230  -27.04764 1.000 26.53492 ? 399  ALA A HA   1 
ATOM   3253 H HB1  . ALA A 1 219 ? -8.41799  15.81067  -24.90245 1.000 24.04844 ? 399  ALA A HB1  1 
ATOM   3254 H HB2  . ALA A 1 219 ? -8.24893  14.34979  -25.50309 1.000 24.04844 ? 399  ALA A HB2  1 
ATOM   3255 H HB3  . ALA A 1 219 ? -7.20925  14.89348  -24.43211 1.000 24.04844 ? 399  ALA A HB3  1 
ATOM   3256 N N    . LYS A 1 220 ? -5.07051  16.72567  -25.10304 1.000 22.09090 ? 400  LYS A N    1 
ATOM   3257 C CA   . LYS A 1 220 ? -4.26762  17.85660  -24.64575 1.000 19.80354 ? 400  LYS A CA   1 
ATOM   3258 C C    . LYS A 1 220 ? -3.65207  18.60233  -25.81510 1.000 20.37938 ? 400  LYS A C    1 
ATOM   3259 O O    . LYS A 1 220 ? -3.55662  19.83611  -25.78676 1.000 22.66976 ? 400  LYS A O    1 
ATOM   3260 C CB   . LYS A 1 220 ? -3.18653  17.36957  -23.68747 1.000 26.17259 ? 400  LYS A CB   1 
ATOM   3261 C CG   . LYS A 1 220 ? -3.77983  17.11729  -22.31857 1.000 25.39701 ? 400  LYS A CG   1 
ATOM   3262 C CD   . LYS A 1 220 ? -2.73023  17.06858  -21.23405 1.000 38.19046 ? 400  LYS A CD   1 
ATOM   3263 C CE   . LYS A 1 220 ? -3.38699  17.01119  -19.86027 1.000 49.42131 ? 400  LYS A CE   1 
ATOM   3264 N NZ   . LYS A 1 220 ? -2.85798  18.09054  -18.96792 1.000 52.51721 ? 400  LYS A NZ   1 
ATOM   3265 H H    . LYS A 1 220 ? -4.77273  15.95453  -24.86585 1.000 26.50908 ? 400  LYS A H    1 
ATOM   3266 H HA   . LYS A 1 220 ? -4.83923  18.47611  -24.16578 1.000 23.76425 ? 400  LYS A HA   1 
ATOM   3267 H HB2  . LYS A 1 220 ? -2.80594  16.54141  -24.01943 1.000 31.40711 ? 400  LYS A HB2  1 
ATOM   3268 H HB3  . LYS A 1 220 ? -2.49419  18.04422  -23.60736 1.000 31.40711 ? 400  LYS A HB3  1 
ATOM   3269 H HG2  . LYS A 1 220 ? -4.40011  17.83175  -22.10478 1.000 30.47641 ? 400  LYS A HG2  1 
ATOM   3270 H HG3  . LYS A 1 220 ? -4.24435  16.26578  -22.32586 1.000 30.47641 ? 400  LYS A HG3  1 
ATOM   3271 H HD2  . LYS A 1 220 ? -2.18134  16.27695  -21.34782 1.000 45.82855 ? 400  LYS A HD2  1 
ATOM   3272 H HD3  . LYS A 1 220 ? -2.17789  17.86465  -21.27984 1.000 45.82855 ? 400  LYS A HD3  1 
ATOM   3273 H HE2  . LYS A 1 220 ? -4.34473  17.13248  -19.95466 1.000 59.30558 ? 400  LYS A HE2  1 
ATOM   3274 H HE3  . LYS A 1 220 ? -3.20025  16.15304  -19.44844 1.000 59.30558 ? 400  LYS A HE3  1 
ATOM   3275 H HZ1  . LYS A 1 220 ? -3.25606  18.05056  -18.17291 1.000 63.02065 ? 400  LYS A HZ1  1 
ATOM   3276 H HZ2  . LYS A 1 220 ? -1.98057  17.99094  -18.85694 1.000 63.02065 ? 400  LYS A HZ2  1 
ATOM   3277 H HZ3  . LYS A 1 220 ? -3.01464  18.88851  -19.32958 1.000 63.02065 ? 400  LYS A HZ3  1 
ATOM   3278 N N    . VAL A 1 221 ? -3.20198  17.88022  -26.84564 1.000 22.15450 ? 401  VAL A N    1 
ATOM   3279 C CA   . VAL A 1 221 ? -2.66723  18.54904  -28.03539 1.000 25.49793 ? 401  VAL A CA   1 
ATOM   3280 C C    . VAL A 1 221 ? -3.73968  19.42122  -28.66530 1.000 23.90662 ? 401  VAL A C    1 
ATOM   3281 O O    . VAL A 1 221 ? -3.49019  20.57432  -29.04137 1.000 26.77887 ? 401  VAL A O    1 
ATOM   3282 C CB   . VAL A 1 221 ? -2.08904  17.50630  -29.00884 1.000 23.88303 ? 401  VAL A CB   1 
ATOM   3283 C CG1  . VAL A 1 221 ? -1.77139  18.13728  -30.34940 1.000 24.98610 ? 401  VAL A CG1  1 
ATOM   3284 C CG2  . VAL A 1 221 ? -0.81829  16.85871  -28.40145 1.000 22.95194 ? 401  VAL A CG2  1 
ATOM   3285 H H    . VAL A 1 221 ? -3.19498  17.02097  -26.88090 1.000 26.58540 ? 401  VAL A H    1 
ATOM   3286 H HA   . VAL A 1 221 ? -1.93706  19.13428  -27.77997 1.000 30.59752 ? 401  VAL A HA   1 
ATOM   3287 H HB   . VAL A 1 221 ? -2.75186  16.81339  -29.15531 1.000 28.65964 ? 401  VAL A HB   1 
ATOM   3288 H HG11 . VAL A 1 221 ? -1.17918  17.54867  -30.84308 1.000 29.98332 ? 401  VAL A HG11 1 
ATOM   3289 H HG12 . VAL A 1 221 ? -2.59719  18.26474  -30.84205 1.000 29.98332 ? 401  VAL A HG12 1 
ATOM   3290 H HG13 . VAL A 1 221 ? -1.33920  18.99293  -30.20121 1.000 29.98332 ? 401  VAL A HG13 1 
ATOM   3291 H HG21 . VAL A 1 221 ? -0.50260  16.16234  -28.99837 1.000 27.54233 ? 401  VAL A HG21 1 
ATOM   3292 H HG22 . VAL A 1 221 ? -0.13558  17.53989  -28.29752 1.000 27.54233 ? 401  VAL A HG22 1 
ATOM   3293 H HG23 . VAL A 1 221 ? -1.04008  16.47812  -27.53723 1.000 27.54233 ? 401  VAL A HG23 1 
ATOM   3294 N N    . LYS A 1 222 ? -4.96312  18.89636  -28.75757 1.000 23.98319 ? 402  LYS A N    1 
ATOM   3295 C CA   . LYS A 1 222 ? -6.07272  19.67691  -29.31232 1.000 29.46520 ? 402  LYS A CA   1 
ATOM   3296 C C    . LYS A 1 222 ? -6.31330  20.95136  -28.50516 1.000 27.39543 ? 402  LYS A C    1 
ATOM   3297 O O    . LYS A 1 222 ? -6.45265  22.03578  -29.07660 1.000 29.66594 ? 402  LYS A O    1 
ATOM   3298 C CB   . LYS A 1 222 ? -7.32593  18.78922  -29.38484 1.000 29.49857 ? 402  LYS A CB   1 
ATOM   3299 C CG   . LYS A 1 222 ? -7.29319  17.82599  -30.60262 1.000 34.70494 ? 402  LYS A CG   1 
ATOM   3300 C CD   . LYS A 1 222 ? -8.55538  16.94120  -30.77062 1.000 39.65078 ? 402  LYS A CD   1 
ATOM   3301 H H    . LYS A 1 222 ? -5.17643  18.10094  -28.50977 1.000 28.77983 ? 402  LYS A H    1 
ATOM   3302 H HA   . LYS A 1 222 ? -5.86073  19.95906  -30.21584 1.000 35.35824 ? 402  LYS A HA   1 
ATOM   3303 H HB2  . LYS A 1 222 ? -7.38386  18.25465  -28.57751 1.000 35.39829 ? 402  LYS A HB2  1 
ATOM   3304 H HB3  . LYS A 1 222 ? -8.11075  19.35345  -29.46616 1.000 35.39829 ? 402  LYS A HB3  1 
ATOM   3305 H HG2  . LYS A 1 222 ? -7.19945  18.35419  -31.41078 1.000 41.64593 ? 402  LYS A HG2  1 
ATOM   3306 H HG3  . LYS A 1 222 ? -6.53301  17.23146  -30.50482 1.000 41.64593 ? 402  LYS A HG3  1 
ATOM   3307 N N    . TYR A 1 223 ? -6.30349  20.84742  -27.18051 1.000 25.64092 ? 403  TYR A N    1 
ATOM   3308 C CA   . TYR A 1 223 ? -6.53408  22.02086  -26.34701 1.000 27.03147 ? 403  TYR A CA   1 
ATOM   3309 C C    . TYR A 1 223 ? -5.39417  23.03247  -26.48126 1.000 28.80487 ? 403  TYR A C    1 
ATOM   3310 O O    . TYR A 1 223 ? -5.63242  24.24402  -26.57508 1.000 30.93146 ? 403  TYR A O    1 
ATOM   3311 C CB   . TYR A 1 223 ? -6.68281  21.56520  -24.90716 1.000 28.88439 ? 403  TYR A CB   1 
ATOM   3312 C CG   . TYR A 1 223 ? -6.81928  22.67896  -23.92397 1.000 30.77641 ? 403  TYR A CG   1 
ATOM   3313 C CD1  . TYR A 1 223 ? -8.03629  23.31364  -23.75175 1.000 36.53962 ? 403  TYR A CD1  1 
ATOM   3314 C CD2  . TYR A 1 223 ? -5.74095  23.09981  -23.18067 1.000 30.07848 ? 403  TYR A CD2  1 
ATOM   3315 C CE1  . TYR A 1 223 ? -8.17342  24.34091  -22.85482 1.000 37.59615 ? 403  TYR A CE1  1 
ATOM   3316 C CE2  . TYR A 1 223 ? -5.85769  24.13386  -22.28633 1.000 36.62274 ? 403  TYR A CE2  1 
ATOM   3317 C CZ   . TYR A 1 223 ? -7.07278  24.75687  -22.13000 1.000 42.33894 ? 403  TYR A CZ   1 
ATOM   3318 O OH   . TYR A 1 223 ? -7.18110  25.78085  -21.22408 1.000 45.28040 ? 403  TYR A OH   1 
ATOM   3319 H H    . TYR A 1 223 ? -6.16756  20.11882  -26.74431 1.000 30.76910 ? 403  TYR A H    1 
ATOM   3320 H HA   . TYR A 1 223 ? -7.34955  22.46712  -26.62405 1.000 32.43777 ? 403  TYR A HA   1 
ATOM   3321 H HB2  . TYR A 1 223 ? -7.47671  21.01226  -24.83733 1.000 34.66127 ? 403  TYR A HB2  1 
ATOM   3322 H HB3  . TYR A 1 223 ? -5.89774  21.05095  -24.66199 1.000 34.66127 ? 403  TYR A HB3  1 
ATOM   3323 H HD1  . TYR A 1 223 ? -8.77132  23.03960  -24.25128 1.000 43.84754 ? 403  TYR A HD1  1 
ATOM   3324 H HD2  . TYR A 1 223 ? -4.91955  22.67661  -23.28603 1.000 36.09418 ? 403  TYR A HD2  1 
ATOM   3325 H HE1  . TYR A 1 223 ? -8.99824  24.75356  -22.73529 1.000 45.11538 ? 403  TYR A HE1  1 
ATOM   3326 H HE2  . TYR A 1 223 ? -5.12125  24.41068  -21.79042 1.000 43.94729 ? 403  TYR A HE2  1 
ATOM   3327 H HH   . TYR A 1 223 ? -6.43659  25.92464  -20.86266 1.000 54.33648 ? 403  TYR A HH   1 
ATOM   3328 N N    . LEU A 1 224 ? -4.15019  22.56083  -26.52027 1.000 23.97701 ? 404  LEU A N    1 
ATOM   3329 C CA   . LEU A 1 224 ? -2.99371  23.46391  -26.49844 1.000 27.10814 ? 404  LEU A CA   1 
ATOM   3330 C C    . LEU A 1 224 ? -2.73848  24.13302  -27.82978 1.000 31.73334 ? 404  LEU A C    1 
ATOM   3331 O O    . LEU A 1 224 ? -1.97902  25.11150  -27.89483 1.000 31.01061 ? 404  LEU A O    1 
ATOM   3332 C CB   . LEU A 1 224 ? -1.75321  22.67130  -26.11715 1.000 27.01261 ? 404  LEU A CB   1 
ATOM   3333 C CG   . LEU A 1 224 ? -1.75087  22.17297  -24.67743 1.000 26.69510 ? 404  LEU A CG   1 
ATOM   3334 C CD1  . LEU A 1 224 ? -0.66826  21.10228  -24.49558 1.000 32.64315 ? 404  LEU A CD1  1 
ATOM   3335 C CD2  . LEU A 1 224 ? -1.49770  23.32837  -23.69832 1.000 32.19590 ? 404  LEU A CD2  1 
ATOM   3336 H H    . LEU A 1 224 ? -3.94590  21.72637  -26.55946 1.000 28.77241 ? 404  LEU A H    1 
ATOM   3337 H HA   . LEU A 1 224 ? -3.15524  24.15737  -25.83972 1.000 32.52977 ? 404  LEU A HA   1 
ATOM   3338 H HB2  . LEU A 1 224 ? -1.68990  21.89683  -26.69774 1.000 32.41513 ? 404  LEU A HB2  1 
ATOM   3339 H HB3  . LEU A 1 224 ? -0.97507  23.23842  -26.23454 1.000 32.41513 ? 404  LEU A HB3  1 
ATOM   3340 H HG   . LEU A 1 224 ? -2.61920  21.78873  -24.47930 1.000 32.03412 ? 404  LEU A HG   1 
ATOM   3341 H HD11 . LEU A 1 224 ? -0.69177  20.78166  -23.58040 1.000 39.17178 ? 404  LEU A HD11 1 
ATOM   3342 H HD12 . LEU A 1 224 ? -0.84253  20.36989  -25.10724 1.000 39.17178 ? 404  LEU A HD12 1 
ATOM   3343 H HD13 . LEU A 1 224 ? 0.19838   21.49381  -24.68674 1.000 39.17178 ? 404  LEU A HD13 1 
ATOM   3344 H HD21 . LEU A 1 224 ? -1.41965  22.96999  -22.80033 1.000 38.63508 ? 404  LEU A HD21 1 
ATOM   3345 H HD22 . LEU A 1 224 ? -0.67554  23.77889  -23.94728 1.000 38.63508 ? 404  LEU A HD22 1 
ATOM   3346 H HD23 . LEU A 1 224 ? -2.24171  23.94913  -23.74321 1.000 38.63508 ? 404  LEU A HD23 1 
ATOM   3347 N N    . THR A 1 225 ? -3.30175  23.61007  -28.90366 1.000 27.82959 ? 405  THR A N    1 
ATOM   3348 C CA   . THR A 1 225 ? -3.20063  24.24637  -30.20290 1.000 28.77931 ? 405  THR A CA   1 
ATOM   3349 C C    . THR A 1 225 ? -4.44324  25.04818  -30.55420 1.000 35.42344 ? 405  THR A C    1 
ATOM   3350 O O    . THR A 1 225 ? -4.47691  25.67439  -31.61446 1.000 42.89341 ? 405  THR A O    1 
ATOM   3351 C CB   . THR A 1 225 ? -2.96264  23.17863  -31.26892 1.000 30.19196 ? 405  THR A CB   1 
ATOM   3352 O OG1  . THR A 1 225 ? -4.04015  22.23983  -31.25289 1.000 35.03369 ? 405  THR A OG1  1 
ATOM   3353 C CG2  . THR A 1 225 ? -1.66234  22.43196  -31.02504 1.000 33.03959 ? 405  THR A CG2  1 
ATOM   3354 H H    . THR A 1 225 ? -3.75342  22.87822  -28.90517 1.000 33.39551 ? 405  THR A H    1 
ATOM   3355 H HA   . THR A 1 225 ? -2.44501  24.85459  -30.20552 1.000 34.53518 ? 405  THR A HA   1 
ATOM   3356 H HB   . THR A 1 225 ? -2.90626  23.61052  -32.13563 1.000 36.23036 ? 405  THR A HB   1 
ATOM   3357 H HG1  . THR A 1 225 ? -4.04764  21.82350  -30.52336 1.000 42.04043 ? 405  THR A HG1  1 
ATOM   3358 H HG21 . THR A 1 225 ? -1.51818  21.77862  -31.72737 1.000 39.64751 ? 405  THR A HG21 1 
ATOM   3359 H HG22 . THR A 1 225 ? -0.91867  23.05469  -31.01692 1.000 39.64751 ? 405  THR A HG22 1 
ATOM   3360 H HG23 . THR A 1 225 ? -1.69825  21.97337  -30.17104 1.000 39.64751 ? 405  THR A HG23 1 
ATOM   3361 N N    . GLY A 1 226 ? -5.44495  25.07163  -29.68573 1.000 42.72740 ? 406  GLY A N    1 
ATOM   3362 C CA   . GLY A 1 226 ? -6.69507  25.74161  -29.99958 1.000 45.64716 ? 406  GLY A CA   1 
ATOM   3363 C C    . GLY A 1 226 ? -7.76942  24.74221  -30.39072 1.000 54.24640 ? 406  GLY A C    1 
ATOM   3364 O O    . GLY A 1 226 ? -8.36935  24.85607  -31.45910 1.000 66.54717 ? 406  GLY A O    1 
ATOM   3365 H H    . GLY A 1 226 ? -5.42413  24.70614  -28.90754 1.000 51.27288 ? 406  GLY A H    1 
ATOM   3366 H HA2  . GLY A 1 226 ? -7.00068  26.23994  -29.22552 1.000 54.77659 ? 406  GLY A HA2  1 
ATOM   3367 H HA3  . GLY A 1 226 ? -6.55868  26.35647  -30.73731 1.000 54.77659 ? 406  GLY A HA3  1 
ATOM   3368 N N    A GLU B 2 1   ? -28.64038 15.54695  -35.32118 0.660 60.15029 ? 523  GLU B N    1 
ATOM   3369 N N    B GLU B 2 1   ? -27.26517 15.28526  -35.48215 0.340 53.08283 ? 523  GLU B N    1 
ATOM   3370 C CA   A GLU B 2 1   ? -28.14160 14.97003  -34.07692 0.660 53.38190 ? 523  GLU B CA   1 
ATOM   3371 C CA   B GLU B 2 1   ? -27.29493 14.75300  -34.12594 0.340 54.16037 ? 523  GLU B CA   1 
ATOM   3372 C C    A GLU B 2 1   ? -27.84558 16.12528  -33.10644 0.660 58.65563 ? 523  GLU B C    1 
ATOM   3373 C C    B GLU B 2 1   ? -26.80010 15.80483  -33.12886 0.340 56.15098 ? 523  GLU B C    1 
ATOM   3374 O O    A GLU B 2 1   ? -28.08562 17.29886  -33.40825 0.660 58.45584 ? 523  GLU B O    1 
ATOM   3375 O O    B GLU B 2 1   ? -25.93137 16.61655  -33.44674 0.340 51.68762 ? 523  GLU B O    1 
ATOM   3376 C CB   A GLU B 2 1   ? -26.92547 14.06929  -34.35525 0.660 52.29194 ? 523  GLU B CB   1 
ATOM   3377 C CB   B GLU B 2 1   ? -26.43913 13.48901  -34.03997 0.340 52.45548 ? 523  GLU B CB   1 
ATOM   3378 C CG   A GLU B 2 1   ? -26.60950 13.06099  -33.22318 0.660 53.33910 ? 523  GLU B CG   1 
ATOM   3379 C CG   B GLU B 2 1   ? -26.86887 12.38300  -34.99612 0.340 42.90033 ? 523  GLU B CG   1 
ATOM   3380 C CD   A GLU B 2 1   ? -25.65602 11.94220  -33.64109 0.660 44.03693 ? 523  GLU B CD   1 
ATOM   3381 C CD   B GLU B 2 1   ? -26.07630 11.10355  -34.79797 0.340 43.27193 ? 523  GLU B CD   1 
ATOM   3382 H HA   A GLU B 2 1   ? -28.78803 14.38476  -33.65207 0.660 64.05828 ? 523  GLU B HA   1 
ATOM   3383 H HA   B GLU B 2 1   ? -28.20383 14.51454  -33.88524 0.340 64.99244 ? 523  GLU B HA   1 
ATOM   3384 H HB2  A GLU B 2 1   ? -27.09503 13.56050  -35.16351 0.660 62.75032 ? 523  GLU B HB2  1 
ATOM   3385 H HB2  B GLU B 2 1   ? -25.52090 13.72047  -34.25016 0.340 62.94658 ? 523  GLU B HB2  1 
ATOM   3386 H HB3  A GLU B 2 1   ? -26.14417 14.63156  -34.47495 0.660 62.75032 ? 523  GLU B HB3  1 
ATOM   3387 H HB3  B GLU B 2 1   ? -26.49435 13.13704  -33.13777 0.340 62.94658 ? 523  GLU B HB3  1 
ATOM   3388 H HG2  A GLU B 2 1   ? -26.19900 13.53873  -32.48552 0.660 64.00692 ? 523  GLU B HG2  1 
ATOM   3389 H HG2  B GLU B 2 1   ? -27.80630 12.18241  -34.84815 0.340 51.48039 ? 523  GLU B HG2  1 
ATOM   3390 H HG3  A GLU B 2 1   ? -27.43810 12.64941  -32.93177 0.660 64.00692 ? 523  GLU B HG3  1 
ATOM   3391 H HG3  B GLU B 2 1   ? -26.73374 12.68256  -35.90875 0.340 51.48039 ? 523  GLU B HG3  1 
ATOM   3392 N N    . LEU B 2 2   ? -27.36570 15.78232  -31.92363 1.000 65.49206 ? 524  LEU B N    1 
ATOM   3393 C CA   . LEU B 2 2   ? -27.01276 16.75490  -30.90391 1.000 50.89015 ? 524  LEU B CA   1 
ATOM   3394 C C    . LEU B 2 2   ? -25.54006 16.60144  -30.58021 1.000 41.57562 ? 524  LEU B C    1 
ATOM   3395 O O    . LEU B 2 2   ? -24.98511 15.50700  -30.67502 1.000 42.99729 ? 524  LEU B O    1 
ATOM   3396 C CB   . LEU B 2 2   ? -27.86123 16.51003  -29.65964 1.000 53.38499 ? 524  LEU B CB   1 
ATOM   3397 C CG   . LEU B 2 2   ? -27.59731 17.40388  -28.45922 1.000 49.43528 ? 524  LEU B CG   1 
ATOM   3398 C CD1  . LEU B 2 2   ? -27.78681 18.83706  -28.89291 1.000 49.83751 ? 524  LEU B CD1  1 
ATOM   3399 C CD2  . LEU B 2 2   ? -28.56383 17.00090  -27.36438 1.000 42.84712 ? 524  LEU B CD2  1 
ATOM   3400 H H    A LEU B 2 2   ? -27.23147 14.96838  -31.68056 0.660 78.59047 ? 524  LEU B H    1 
ATOM   3401 H H    B LEU B 2 2   ? -27.95803 15.21106  -31.67380 0.340 78.59047 ? 524  LEU B H    1 
ATOM   3402 H HA   . LEU B 2 2   ? -27.16922 17.66302  -31.20679 1.000 61.06818 ? 524  LEU B HA   1 
ATOM   3403 H HB2  . LEU B 2 2   ? -28.79198 16.63183  -29.90411 1.000 64.06198 ? 524  LEU B HB2  1 
ATOM   3404 H HB3  . LEU B 2 2   ? -27.71093 15.59633  -29.37073 1.000 64.06198 ? 524  LEU B HB3  1 
ATOM   3405 H HG   . LEU B 2 2   ? -26.69599 17.31804  -28.11114 1.000 59.32234 ? 524  LEU B HG   1 
ATOM   3406 H HD11 . LEU B 2 2   ? -28.12123 19.35255  -28.14235 1.000 59.80501 ? 524  LEU B HD11 1 
ATOM   3407 H HD12 . LEU B 2 2   ? -26.93358 19.19396  -29.18535 1.000 59.80501 ? 524  LEU B HD12 1 
ATOM   3408 H HD13 . LEU B 2 2   ? -28.42458 18.86430  -29.62327 1.000 59.80501 ? 524  LEU B HD13 1 
ATOM   3409 H HD21 . LEU B 2 2   ? -28.41194 17.56101  -26.58714 1.000 51.41655 ? 524  LEU B HD21 1 
ATOM   3410 H HD22 . LEU B 2 2   ? -29.47157 17.11933  -27.68515 1.000 51.41655 ? 524  LEU B HD22 1 
ATOM   3411 H HD23 . LEU B 2 2   ? -28.41240 16.07036  -27.13621 1.000 51.41655 ? 524  LEU B HD23 1 
ATOM   3412 N N    . ASP B 2 3   ? -24.87480 17.71760  -30.26200 1.000 35.20807 ? 525  ASP B N    1 
ATOM   3413 C CA   . ASP B 2 3   ? -23.46865 17.64095  -29.88020 1.000 26.36607 ? 525  ASP B CA   1 
ATOM   3414 C C    . ASP B 2 3   ? -23.38942 17.15972  -28.43611 1.000 23.47987 ? 525  ASP B C    1 
ATOM   3415 O O    . ASP B 2 3   ? -23.68673 17.90080  -27.49909 1.000 21.14912 ? 525  ASP B O    1 
ATOM   3416 C CB   . ASP B 2 3   ? -22.76016 18.97967  -30.04459 1.000 27.41847 ? 525  ASP B CB   1 
ATOM   3417 C CG   . ASP B 2 3   ? -21.27374 18.90412  -29.69649 1.000 32.03522 ? 525  ASP B CG   1 
ATOM   3418 O OD1  . ASP B 2 3   ? -20.80038 17.87660  -29.14509 1.000 26.80866 ? 525  ASP B OD1  1 
ATOM   3419 O OD2  . ASP B 2 3   ? -20.56712 19.88486  -29.99390 1.000 35.04450 ? 525  ASP B OD2  1 
ATOM   3420 H H    . ASP B 2 3   ? -25.21111 18.50912  -30.26101 1.000 42.24968 ? 525  ASP B H    1 
ATOM   3421 H HA   . ASP B 2 3   ? -23.02294 17.00534  -30.46178 1.000 31.63928 ? 525  ASP B HA   1 
ATOM   3422 H HB2  . ASP B 2 3   ? -22.83853 19.26828  -30.96734 1.000 32.90216 ? 525  ASP B HB2  1 
ATOM   3423 H HB3  . ASP B 2 3   ? -23.17380 19.63119  -29.45695 1.000 32.90216 ? 525  ASP B HB3  1 
ATOM   3424 N N    . LEU B 2 4   ? -22.99559 15.90382  -28.23978 1.000 21.67593 ? 526  LEU B N    1 
ATOM   3425 C CA   . LEU B 2 4   ? -23.00934 15.32344  -26.89966 1.000 17.60261 ? 526  LEU B CA   1 
ATOM   3426 C C    . LEU B 2 4   ? -22.02337 15.99529  -25.95567 1.000 16.52441 ? 526  LEU B C    1 
ATOM   3427 O O    . LEU B 2 4   ? -22.17270 15.85348  -24.71567 1.000 15.63689 ? 526  LEU B O    1 
ATOM   3428 C CB   . LEU B 2 4   ? -22.73303 13.82115  -27.01373 1.000 18.91720 ? 526  LEU B CB   1 
ATOM   3429 C CG   . LEU B 2 4   ? -23.83228 12.93713  -27.58416 1.000 19.42309 ? 526  LEU B CG   1 
ATOM   3430 C CD1  . LEU B 2 4   ? -23.28738 11.52057  -27.82310 1.000 22.64772 ? 526  LEU B CD1  1 
ATOM   3431 C CD2  . LEU B 2 4   ? -25.01938 12.94647  -26.64761 1.000 26.67637 ? 526  LEU B CD2  1 
ATOM   3432 H H    . LEU B 2 4   ? -22.71931 15.37273  -28.85721 1.000 26.01112 ? 526  LEU B H    1 
ATOM   3433 H HA   . LEU B 2 4   ? -23.88566 15.44238  -26.50114 1.000 21.12313 ? 526  LEU B HA   1 
ATOM   3434 H HB2  . LEU B 2 4   ? -21.95776 13.70632  -27.58528 1.000 22.70064 ? 526  LEU B HB2  1 
ATOM   3435 H HB3  . LEU B 2 4   ? -22.54094 13.48805  -26.12320 1.000 22.70064 ? 526  LEU B HB3  1 
ATOM   3436 H HG   . LEU B 2 4   ? -24.13707 13.27199  -28.44199 1.000 23.30771 ? 526  LEU B HG   1 
ATOM   3437 H HD11 . LEU B 2 4   ? -23.98686 10.97521  -28.21578 1.000 27.17726 ? 526  LEU B HD11 1 
ATOM   3438 H HD12 . LEU B 2 4   ? -22.52954 11.57133  -28.42642 1.000 27.17726 ? 526  LEU B HD12 1 
ATOM   3439 H HD13 . LEU B 2 4   ? -23.00973 11.14170  -26.97441 1.000 27.17726 ? 526  LEU B HD13 1 
ATOM   3440 H HD21 . LEU B 2 4   ? -25.64823 12.26322  -26.92802 1.000 32.01164 ? 526  LEU B HD21 1 
ATOM   3441 H HD22 . LEU B 2 4   ? -24.71185 12.76306  -25.74612 1.000 32.01164 ? 526  LEU B HD22 1 
ATOM   3442 H HD23 . LEU B 2 4   ? -25.44183 13.81897  -26.68191 1.000 32.01164 ? 526  LEU B HD23 1 
ATOM   3443 N N    . GLU B 2 5   ? -21.04434 16.74644  -26.47032 1.000 17.02363 ? 527  GLU B N    1 
ATOM   3444 C CA   . GLU B 2 5   ? -20.16637 17.47114  -25.54692 1.000 17.96856 ? 527  GLU B CA   1 
ATOM   3445 C C    . GLU B 2 5   ? -20.95857 18.47414  -24.72525 1.000 16.41198 ? 527  GLU B C    1 
ATOM   3446 O O    . GLU B 2 5   ? -20.53808 18.84391  -23.60968 1.000 18.66101 ? 527  GLU B O    1 
ATOM   3447 C CB   . GLU B 2 5   ? -18.91994 18.12598  -26.21527 1.000 22.21880 ? 527  GLU B CB   1 
ATOM   3448 C CG   . GLU B 2 5   ? -17.74054 17.08249  -26.38142 1.000 28.44410 ? 527  GLU B CG   1 
ATOM   3449 C CD   . GLU B 2 5   ? -16.34934 17.68943  -26.61109 1.000 40.97593 ? 527  GLU B CD   1 
ATOM   3450 O OE1  . GLU B 2 5   ? -16.29559 18.80734  -27.14004 1.000 32.50085 ? 527  GLU B OE1  1 
ATOM   3451 O OE2  . GLU B 2 5   ? -15.31291 17.02295  -26.28677 1.000 38.15124 ? 527  GLU B OE2  1 
ATOM   3452 H H    . GLU B 2 5   ? -20.87583 16.84811  -27.30750 1.000 20.42836 ? 527  GLU B H    1 
ATOM   3453 H HA   . GLU B 2 5   ? -19.76702 16.81427  -24.95536 1.000 21.56228 ? 527  GLU B HA   1 
ATOM   3454 H HB2  . GLU B 2 5   ? -19.16316 18.45600  -27.09438 1.000 26.66257 ? 527  GLU B HB2  1 
ATOM   3455 H HB3  . GLU B 2 5   ? -18.60585 18.85774  -25.66140 1.000 26.66257 ? 527  GLU B HB3  1 
ATOM   3456 H HG2  . GLU B 2 5   ? -17.69139 16.54590  -25.57485 1.000 34.13292 ? 527  GLU B HG2  1 
ATOM   3457 H HG3  . GLU B 2 5   ? -17.93797 16.51713  -27.14450 1.000 34.13292 ? 527  GLU B HG3  1 
ATOM   3458 N N    . THR B 2 6   ? -22.13578 18.90493  -25.23118 1.000 16.26091 ? 528  THR B N    1 
ATOM   3459 C CA   . THR B 2 6   ? -22.92151 19.88336  -24.47684 1.000 16.54231 ? 528  THR B CA   1 
ATOM   3460 C C    . THR B 2 6   ? -23.62164 19.26138  -23.26983 1.000 14.07511 ? 528  THR B C    1 
ATOM   3461 O O    . THR B 2 6   ? -24.18005 20.00740  -22.44146 1.000 17.24465 ? 528  THR B O    1 
ATOM   3462 C CB   . THR B 2 6   ? -23.95369 20.59398  -25.37269 1.000 17.97590 ? 528  THR B CB   1 
ATOM   3463 O OG1  . THR B 2 6   ? -24.92510 19.63347  -25.84147 1.000 20.36949 ? 528  THR B OG1  1 
ATOM   3464 C CG2  . THR B 2 6   ? -23.28973 21.31774  -26.52089 1.000 20.99910 ? 528  THR B CG2  1 
ATOM   3465 H H    . THR B 2 6   ? -22.47911 18.65153  -25.97784 1.000 19.51310 ? 528  THR B H    1 
ATOM   3466 H HA   . THR B 2 6   ? -22.31412 20.56987  -24.15955 1.000 19.85078 ? 528  THR B HA   1 
ATOM   3467 H HB   . THR B 2 6   ? -24.41737 21.27445  -24.86000 1.000 21.57108 ? 528  THR B HB   1 
ATOM   3468 H HG1  . THR B 2 6   ? -24.54007 19.01897  -26.26542 1.000 24.44338 ? 528  THR B HG1  1 
ATOM   3469 H HG21 . THR B 2 6   ? -23.95814 21.77053  -27.05858 1.000 25.19892 ? 528  THR B HG21 1 
ATOM   3470 H HG22 . THR B 2 6   ? -22.66191 21.97422  -26.18062 1.000 25.19892 ? 528  THR B HG22 1 
ATOM   3471 H HG23 . THR B 2 6   ? -22.81177 20.68522  -27.07980 1.000 25.19892 ? 528  THR B HG23 1 
ATOM   3472 N N    . LEU B 2 7   ? -23.60347 17.93056  -23.15631 1.000 14.71221 ? 529  LEU B N    1 
ATOM   3473 C CA   . LEU B 2 7   ? -24.21053 17.26876  -22.01492 1.000 14.84333 ? 529  LEU B CA   1 
ATOM   3474 C C    . LEU B 2 7   ? -23.18842 16.58610  -21.13316 1.000 15.73126 ? 529  LEU B C    1 
ATOM   3475 O O    . LEU B 2 7   ? -23.56837 16.04688  -20.09434 1.000 15.97133 ? 529  LEU B O    1 
ATOM   3476 C CB   . LEU B 2 7   ? -25.22143 16.23098  -22.50001 1.000 15.79597 ? 529  LEU B CB   1 
ATOM   3477 C CG   . LEU B 2 7   ? -26.25775 16.67873  -23.53020 1.000 15.06486 ? 529  LEU B CG   1 
ATOM   3478 C CD1  . LEU B 2 7   ? -27.15484 15.48217  -23.88008 1.000 18.82122 ? 529  LEU B CD1  1 
ATOM   3479 C CD2  . LEU B 2 7   ? -27.06111 17.84030  -22.99484 1.000 17.57406 ? 529  LEU B CD2  1 
ATOM   3480 H H    . LEU B 2 7   ? -23.24541 17.39778  -23.72862 1.000 17.65465 ? 529  LEU B H    1 
ATOM   3481 H HA   . LEU B 2 7   ? -24.68054 17.92893  -21.48185 1.000 17.81200 ? 529  LEU B HA   1 
ATOM   3482 H HB2  . LEU B 2 7   ? -24.72581 15.49977  -22.90077 1.000 18.95517 ? 529  LEU B HB2  1 
ATOM   3483 H HB3  . LEU B 2 7   ? -25.71389 15.91358  -21.72694 1.000 18.95517 ? 529  LEU B HB3  1 
ATOM   3484 H HG   . LEU B 2 7   ? -25.82460 16.98623  -24.34182 1.000 18.07783 ? 529  LEU B HG   1 
ATOM   3485 H HD11 . LEU B 2 7   ? -27.82728 15.76756  -24.51826 1.000 22.58547 ? 529  LEU B HD11 1 
ATOM   3486 H HD12 . LEU B 2 7   ? -26.60842 14.78028  -24.26697 1.000 22.58547 ? 529  LEU B HD12 1 
ATOM   3487 H HD13 . LEU B 2 7   ? -27.58217 15.16057  -23.07085 1.000 22.58547 ? 529  LEU B HD13 1 
ATOM   3488 H HD21 . LEU B 2 7   ? -27.75153 18.06919  -23.63657 1.000 21.08887 ? 529  LEU B HD21 1 
ATOM   3489 H HD22 . LEU B 2 7   ? -27.46552 17.58262  -22.15166 1.000 21.08887 ? 529  LEU B HD22 1 
ATOM   3490 H HD23 . LEU B 2 7   ? -26.47018 18.59770  -22.86047 1.000 21.08887 ? 529  LEU B HD23 1 
ATOM   3491 N N    . ALA B 2 8   ? -21.90465 16.59350  -21.53435 1.000 13.04368 ? 530  ALA B N    1 
ATOM   3492 C CA   . ALA B 2 8   ? -20.86874 15.81864  -20.85569 1.000 13.87845 ? 530  ALA B CA   1 
ATOM   3493 C C    . ALA B 2 8   ? -20.35409 16.59033  -19.65177 1.000 13.63591 ? 530  ALA B C    1 
ATOM   3494 O O    . ALA B 2 8   ? -20.14345 17.79609  -19.74335 1.000 15.09187 ? 530  ALA B O    1 
ATOM   3495 C CB   . ALA B 2 8   ? -19.78420 15.48307  -21.78446 1.000 15.16527 ? 530  ALA B CB   1 
ATOM   3496 H H    . ALA B 2 8   ? -21.61240 17.04617  -22.20463 1.000 15.65241 ? 530  ALA B H    1 
ATOM   3497 H HA   . ALA B 2 8   ? -21.23617 14.97788  -20.54104 1.000 16.65413 ? 530  ALA B HA   1 
ATOM   3498 H HB1  . ALA B 2 8   ? -19.09079 15.00686  -21.30144 1.000 18.19832 ? 530  ALA B HB1  1 
ATOM   3499 H HB2  . ALA B 2 8   ? -20.13749 14.92326  -22.49347 1.000 18.19832 ? 530  ALA B HB2  1 
ATOM   3500 H HB3  . ALA B 2 8   ? -19.42381 16.30234  -22.15837 1.000 18.19832 ? 530  ALA B HB3  1 
HETATM 3501 N N    . HYP B 2 9   ? -20.13964 15.91614  -18.54182 1.000 14.66791 ? 531  HYP B N    1 
HETATM 3502 C CA   . HYP B 2 9   ? -19.68610 16.67217  -17.32534 1.000 14.02852 ? 531  HYP B CA   1 
HETATM 3503 C C    . HYP B 2 9   ? -18.23857 17.23747  -17.50240 1.000 13.92000 ? 531  HYP B C    1 
HETATM 3504 O O    . HYP B 2 9   ? -17.31500 16.49745  -17.92400 1.000 15.07149 ? 531  HYP B O    1 
HETATM 3505 C CB   . HYP B 2 9   ? -19.72304 15.67623  -16.18604 1.000 14.42793 ? 531  HYP B CB   1 
HETATM 3506 C CG   . HYP B 2 9   ? -19.73483 14.30710  -16.83148 1.000 14.80064 ? 531  HYP B CG   1 
HETATM 3507 C CD   . HYP B 2 9   ? -20.31991 14.47304  -18.20063 1.000 15.31237 ? 531  HYP B CD   1 
HETATM 3508 O OD1  . HYP B 2 9   ? -20.43126 13.37360  -16.03575 1.000 16.30547 ? 531  HYP B OD1  1 
HETATM 3509 H HG   . HYP B 2 9   ? -18.84688 13.93589  -16.95244 1.000 17.76076 ? 531  HYP B HG   1 
HETATM 3510 H HD22 . HYP B 2 9   ? -19.87513 13.89459  -18.83974 1.000 18.37484 ? 531  HYP B HD22 1 
HETATM 3511 H HD23 . HYP B 2 9   ? -21.25506 14.21559  -18.21115 1.000 18.37484 ? 531  HYP B HD23 1 
HETATM 3512 H HD1  . HYP B 2 9   ? -20.37053 12.59299  -16.37312 1.000 19.56656 ? 531  HYP B HD1  1 
ATOM   3513 N N    . TYR B 2 10  ? -18.08669 18.48807  -17.19733 1.000 14.45806 ? 532  TYR B N    1 
ATOM   3514 C CA   . TYR B 2 10  ? -16.80083 19.15769  -17.32355 1.000 14.86301 ? 532  TYR B CA   1 
ATOM   3515 C C    . TYR B 2 10  ? -15.66390 18.56481  -16.53216 1.000 15.57410 ? 532  TYR B C    1 
ATOM   3516 O O    . TYR B 2 10  ? -15.85776 18.13256  -15.40910 1.000 16.48529 ? 532  TYR B O    1 
ATOM   3517 C CB   . TYR B 2 10  ? -16.98639 20.58645  -16.83934 1.000 16.30074 ? 532  TYR B CB   1 
ATOM   3518 C CG   . TYR B 2 10  ? -15.74094 21.43670  -16.90012 1.000 18.22692 ? 532  TYR B CG   1 
ATOM   3519 C CD1  . TYR B 2 10  ? -15.30871 22.02552  -18.09409 1.000 19.85119 ? 532  TYR B CD1  1 
ATOM   3520 C CD2  . TYR B 2 10  ? -15.00227 21.67036  -15.76468 1.000 21.73217 ? 532  TYR B CD2  1 
ATOM   3521 C CE1  . TYR B 2 10  ? -14.18317 22.78577  -18.15256 1.000 21.35866 ? 532  TYR B CE1  1 
ATOM   3522 C CE2  . TYR B 2 10  ? -13.86166 22.46628  -15.80048 1.000 23.13034 ? 532  TYR B CE2  1 
ATOM   3523 C CZ   . TYR B 2 10  ? -13.46483 23.02153  -16.98132 1.000 22.48020 ? 532  TYR B CZ   1 
ATOM   3524 O OH   . TYR B 2 10  ? -12.29202 23.77988  -16.96415 1.000 28.24966 ? 532  TYR B OH   1 
ATOM   3525 H H    . TYR B 2 10  ? -18.71737 18.99562  -16.90710 1.000 17.34968 ? 532  TYR B H    1 
ATOM   3526 H HA   . TYR B 2 10  ? -16.53640 19.08430  -18.25392 1.000 17.83561 ? 532  TYR B HA   1 
ATOM   3527 H HB2  . TYR B 2 10  ? -17.65989 21.01427  -17.39095 1.000 19.56089 ? 532  TYR B HB2  1 
ATOM   3528 H HB3  . TYR B 2 10  ? -17.28011 20.56345  -15.91516 1.000 19.56089 ? 532  TYR B HB3  1 
ATOM   3529 H HD1  . TYR B 2 10  ? -15.80537 21.89298  -18.86911 1.000 23.82143 ? 532  TYR B HD1  1 
ATOM   3530 H HD2  . TYR B 2 10  ? -15.26938 21.29010  -14.95910 1.000 26.07861 ? 532  TYR B HD2  1 
ATOM   3531 H HE1  . TYR B 2 10  ? -13.89668 23.14325  -18.96190 1.000 25.63039 ? 532  TYR B HE1  1 
ATOM   3532 H HE2  . TYR B 2 10  ? -13.37289 22.61873  -15.02410 1.000 27.75641 ? 532  TYR B HE2  1 
ATOM   3533 H HH   . TYR B 2 10  ? -12.11600 24.05433  -17.73829 1.000 33.89959 ? 532  TYR B HH   1 
ATOM   3534 N N    . ILE B 2 11  ? -14.47483 18.54927  -17.13198 1.000 15.97069 ? 533  ILE B N    1 
ATOM   3535 C CA   . ILE B 2 11  ? -13.22928 18.33052  -16.39802 1.000 17.91349 ? 533  ILE B CA   1 
ATOM   3536 C C    . ILE B 2 11  ? -12.21618 19.35744  -16.84135 1.000 19.10102 ? 533  ILE B C    1 
ATOM   3537 O O    . ILE B 2 11  ? -12.21086 19.83146  -17.98642 1.000 19.12323 ? 533  ILE B O    1 
ATOM   3538 C CB   . ILE B 2 11  ? -12.64210 16.91150  -16.62593 1.000 15.88164 ? 533  ILE B CB   1 
ATOM   3539 C CG1  . ILE B 2 11  ? -12.40582 16.66117  -18.12346 1.000 16.49080 ? 533  ILE B CG1  1 
ATOM   3540 C CG2  . ILE B 2 11  ? -13.53955 15.86601  -16.05548 1.000 16.27842 ? 533  ILE B CG2  1 
ATOM   3541 C CD1  . ILE B 2 11  ? -11.38247 15.53817  -18.42066 1.000 17.29044 ? 533  ILE B CD1  1 
ATOM   3542 H H    . ILE B 2 11  ? -14.36042 18.66472  -17.97648 1.000 19.16483 ? 533  ILE B H    1 
ATOM   3543 H HA   . ILE B 2 11  ? -13.40021 18.43484  -15.44892 1.000 21.49619 ? 533  ILE B HA   1 
ATOM   3544 H HB   . ILE B 2 11  ? -11.78926 16.86302  -16.16634 1.000 19.05797 ? 533  ILE B HB   1 
ATOM   3545 H HG12 . ILE B 2 11  ? -13.24804 16.40874  -18.53315 1.000 19.78896 ? 533  ILE B HG12 1 
ATOM   3546 H HG13 . ILE B 2 11  ? -12.07256 17.47814  -18.52645 1.000 19.78896 ? 533  ILE B HG13 1 
ATOM   3547 H HG21 . ILE B 2 11  ? -13.16143 14.99153  -16.23773 1.000 19.53410 ? 533  ILE B HG21 1 
ATOM   3548 H HG22 . ILE B 2 11  ? -13.61333 16.00142  -15.09781 1.000 19.53410 ? 533  ILE B HG22 1 
ATOM   3549 H HG23 . ILE B 2 11  ? -14.41403 15.94087  -16.46848 1.000 19.53410 ? 533  ILE B HG23 1 
ATOM   3550 H HD11 . ILE B 2 11  ? -11.68196 14.71806  -17.99803 1.000 20.74852 ? 533  ILE B HD11 1 
ATOM   3551 H HD12 . ILE B 2 11  ? -11.32145 15.41246  -19.38054 1.000 20.74852 ? 533  ILE B HD12 1 
ATOM   3552 H HD13 . ILE B 2 11  ? -10.51775 15.79676  -18.06529 1.000 20.74852 ? 533  ILE B HD13 1 
ATOM   3553 N N    . PRO B 2 12  ? -11.32013 19.72982  -15.94124 1.000 21.66355 ? 534  PRO B N    1 
ATOM   3554 C CA   . PRO B 2 12  ? -10.25238 20.66039  -16.33427 1.000 25.54970 ? 534  PRO B CA   1 
ATOM   3555 C C    . PRO B 2 12  ? -9.44801  20.10539  -17.49482 1.000 25.75588 ? 534  PRO B C    1 
ATOM   3556 O O    . PRO B 2 12  ? -9.01925  18.96488  -17.47626 1.000 23.54587 ? 534  PRO B O    1 
ATOM   3557 C CB   . PRO B 2 12  ? -9.39872  20.78083  -15.06923 1.000 30.68478 ? 534  PRO B CB   1 
ATOM   3558 C CG   . PRO B 2 12  ? -10.29226 20.38415  -13.95760 1.000 28.07966 ? 534  PRO B CG   1 
ATOM   3559 C CD   . PRO B 2 12  ? -11.26031 19.36506  -14.51405 1.000 26.91774 ? 534  PRO B CD   1 
ATOM   3560 H HA   . PRO B 2 12  ? -10.62049 21.52706  -16.56724 1.000 30.65964 ? 534  PRO B HA   1 
ATOM   3561 H HB2  . PRO B 2 12  ? -8.63541  20.18530  -15.12929 1.000 36.82174 ? 534  PRO B HB2  1 
ATOM   3562 H HB3  . PRO B 2 12  ? -9.09742  21.69652  -14.96140 1.000 36.82174 ? 534  PRO B HB3  1 
ATOM   3563 H HG2  . PRO B 2 12  ? -9.76469  19.99615  -13.24204 1.000 33.69560 ? 534  PRO B HG2  1 
ATOM   3564 H HG3  . PRO B 2 12  ? -10.76928 21.16383  -13.63287 1.000 33.69560 ? 534  PRO B HG3  1 
ATOM   3565 H HD2  . PRO B 2 12  ? -10.92160 18.46346  -14.39874 1.000 32.30128 ? 534  PRO B HD2  1 
ATOM   3566 H HD3  . PRO B 2 12  ? -12.13184 19.44800  -14.09639 1.000 32.30128 ? 534  PRO B HD3  1 
ATOM   3567 N N    . MET B 2 13  ? -9.21054  20.93478  -18.50626 1.000 32.30817 ? 535  MET B N    1 
ATOM   3568 C CA   . MET B 2 13  ? -8.35327  20.47254  -19.58745 1.000 29.73070 ? 535  MET B CA   1 
ATOM   3569 C C    . MET B 2 13  ? -6.90677  20.95954  -19.45072 1.000 40.79320 ? 535  MET B C    1 
ATOM   3570 O O    . MET B 2 13  ? -6.00492  20.33556  -20.01758 1.000 42.92041 ? 535  MET B O    1 
ATOM   3571 C CB   . MET B 2 13  ? -8.90497  20.89887  -20.95807 1.000 36.84982 ? 535  MET B CB   1 
ATOM   3572 C CG   . MET B 2 13  ? -10.25022 20.25897  -21.38353 1.000 29.33234 ? 535  MET B CG   1 
ATOM   3573 S SD   . MET B 2 13  ? -10.28897 18.43480  -21.40224 1.000 37.40656 ? 535  MET B SD   1 
ATOM   3574 C CE   . MET B 2 13  ? -9.40131  18.11432  -22.95830 1.000 40.91233 ? 535  MET B CE   1 
ATOM   3575 H H    . MET B 2 13  ? -9.52094  21.73304  -18.58391 1.000 38.76981 ? 535  MET B H    1 
ATOM   3576 H HA   . MET B 2 13  ? -8.35830  19.50259  -19.57985 1.000 35.67685 ? 535  MET B HA   1 
ATOM   3577 H HB2  . MET B 2 13  ? -9.03727  21.85972  -20.94501 1.000 44.21979 ? 535  MET B HB2  1 
ATOM   3578 H HB3  . MET B 2 13  ? -8.25028  20.66329  -21.63393 1.000 44.21979 ? 535  MET B HB3  1 
ATOM   3579 H HG2  . MET B 2 13  ? -10.93698 20.55451  -20.76555 1.000 35.19881 ? 535  MET B HG2  1 
ATOM   3580 H HG3  . MET B 2 13  ? -10.46012 20.55993  -22.28146 1.000 35.19881 ? 535  MET B HG3  1 
ATOM   3581 H HE1  . MET B 2 13  ? -9.33555  17.15594  -23.09274 1.000 49.09480 ? 535  MET B HE1  1 
ATOM   3582 H HE2  . MET B 2 13  ? -9.89230  18.51819  -23.69091 1.000 49.09480 ? 535  MET B HE2  1 
ATOM   3583 H HE3  . MET B 2 13  ? -8.51398  18.50200  -22.90131 1.000 49.09480 ? 535  MET B HE3  1 
ATOM   3584 N N    . ASP B 2 14  ? -6.70032  22.05699  -18.70111 1.000 40.69479 ? 536  ASP B N    1 
ATOM   3585 C CA   . ASP B 2 14  ? -5.44085  22.73616  -18.42446 1.000 51.84727 ? 536  ASP B CA   1 
ATOM   3586 C C    . ASP B 2 14  ? -4.90255  22.20681  -17.10131 1.000 36.45886 ? 536  ASP B C    1 
ATOM   3587 O O    . ASP B 2 14  ? -5.44171  21.26100  -16.52583 1.000 62.77642 ? 536  ASP B O    1 
ATOM   3588 C CB   . ASP B 2 14  ? -5.68237  24.25691  -18.41053 1.000 45.87047 ? 536  ASP B CB   1 
ATOM   3589 H H    . ASP B 2 14  ? -7.34756  22.46169  -18.30499 1.000 48.83375 ? 536  ASP B H    1 
ATOM   3590 H HA   . ASP B 2 14  ? -4.78878  22.55047  -19.11816 1.000 62.21673 ? 536  ASP B HA   1 
ATOM   3591 N N    . GLY B 2 15  ? -3.83121  22.81005  -16.60251 1.000 52.06660 ? 537  GLY B N    1 
ATOM   3592 C CA   . GLY B 2 15  ? -3.18179  22.17149  -15.47426 1.000 45.88468 ? 537  GLY B CA   1 
ATOM   3593 C C    . GLY B 2 15  ? -2.56893  20.86584  -15.93760 1.000 47.76116 ? 537  GLY B C    1 
ATOM   3594 O O    . GLY B 2 15  ? -2.43677  20.59801  -17.14662 1.000 62.49036 ? 537  GLY B O    1 
ATOM   3595 H H    . GLY B 2 15  ? -3.48317  23.54460  -16.88343 1.000 62.47992 ? 537  GLY B H    1 
ATOM   3596 H HA2  . GLY B 2 15  ? -2.48432  22.74536  -15.12055 1.000 55.06162 ? 537  GLY B HA2  1 
ATOM   3597 H HA3  . GLY B 2 15  ? -3.82814  21.99150  -14.77373 1.000 55.06162 ? 537  GLY B HA3  1 
ATOM   3598 N N    . GLU B 2 16  ? -2.20257  20.02959  -14.96125 1.000 59.84695 ? 538  GLU B N    1 
ATOM   3599 C CA   . GLU B 2 16  ? -1.58068  18.74180  -15.28127 1.000 53.38995 ? 538  GLU B CA   1 
ATOM   3600 C C    . GLU B 2 16  ? -2.57429  17.62461  -15.51217 1.000 45.94493 ? 538  GLU B C    1 
ATOM   3601 O O    . GLU B 2 16  ? -2.63511  17.04077  -16.59650 1.000 76.92258 ? 538  GLU B O    1 
ATOM   3602 C CB   . GLU B 2 16  ? -0.83841  18.15901  -14.07908 1.000 52.79569 ? 538  GLU B CB   1 
ATOM   3603 H H    . GLU B 2 16  ? -2.30197  20.18285  -14.12087 1.000 71.81634 ? 538  GLU B H    1 
ATOM   3604 H HA   . GLU B 2 16  ? -1.02815  18.95653  -16.04906 1.000 64.06794 ? 538  GLU B HA   1 
ATOM   3605 N N    . ASP B 2 17  ? -3.32430  17.30430  -14.46039 1.000 55.96257 ? 539  ASP B N    1 
ATOM   3606 C CA   . ASP B 2 17  ? -3.96028  16.00897  -14.22399 1.000 35.91314 ? 539  ASP B CA   1 
ATOM   3607 C C    . ASP B 2 17  ? -3.11064  15.27040  -13.17664 1.000 26.33979 ? 539  ASP B C    1 
ATOM   3608 O O    . ASP B 2 17  ? -1.89303  15.43586  -13.13857 1.000 33.56352 ? 539  ASP B O    1 
ATOM   3609 C CB   . ASP B 2 17  ? -3.95303  15.06289  -15.42423 1.000 25.90111 ? 539  ASP B CB   1 
ATOM   3610 C CG   . ASP B 2 17  ? -4.78630  15.57492  -16.61503 1.000 27.60993 ? 539  ASP B CG   1 
ATOM   3611 O OD1  . ASP B 2 17  ? -5.78689  16.30919  -16.43437 1.000 24.40001 ? 539  ASP B OD1  1 
ATOM   3612 O OD2  . ASP B 2 17  ? -4.46119  15.11469  -17.73482 1.000 24.59670 ? 539  ASP B OD2  1 
ATOM   3613 H H    . ASP B 2 17  ? -3.49261  17.85770  -13.82398 1.000 67.15509 ? 539  ASP B H    1 
ATOM   3614 H HA   . ASP B 2 17  ? -4.88055  16.19421  -13.97967 1.000 43.09577 ? 539  ASP B HA   1 
ATOM   3615 H HB2  . ASP B 2 17  ? -3.03894  14.94978  -15.72843 1.000 31.08134 ? 539  ASP B HB2  1 
ATOM   3616 H HB3  . ASP B 2 17  ? -4.32004  14.20755  -15.15111 1.000 31.08134 ? 539  ASP B HB3  1 
ATOM   3617 N N    . PHE B 2 18  ? -3.71024  14.39188  -12.40312 1.000 22.45702 ? 540  PHE B N    1 
ATOM   3618 C CA   . PHE B 2 18  ? -2.95859  13.62905  -11.40380 1.000 18.62396 ? 540  PHE B CA   1 
ATOM   3619 C C    . PHE B 2 18  ? -2.29601  12.40859  -12.03494 1.000 18.03438 ? 540  PHE B C    1 
ATOM   3620 O O    . PHE B 2 18  ? -2.93134  11.68658  -12.79667 1.000 18.36030 ? 540  PHE B O    1 
ATOM   3621 C CB   . PHE B 2 18  ? -3.92400  13.15581  -10.33639 1.000 18.28594 ? 540  PHE B CB   1 
ATOM   3622 C CG   . PHE B 2 18  ? -3.26980  12.43593  -9.24151  1.000 18.66799 ? 540  PHE B CG   1 
ATOM   3623 C CD1  . PHE B 2 18  ? -2.70319  13.14594  -8.20072  1.000 23.61230 ? 540  PHE B CD1  1 
ATOM   3624 C CD2  . PHE B 2 18  ? -3.16684  11.06325  -9.25206  1.000 19.64584 ? 540  PHE B CD2  1 
ATOM   3625 C CE1  . PHE B 2 18  ? -2.07216  12.48441  -7.15424  1.000 25.45805 ? 540  PHE B CE1  1 
ATOM   3626 C CE2  . PHE B 2 18  ? -2.53587  10.39393  -8.19919  1.000 20.47927 ? 540  PHE B CE2  1 
ATOM   3627 C CZ   . PHE B 2 18  ? -1.98905  11.11177  -7.15939  1.000 26.39094 ? 540  PHE B CZ   1 
ATOM   3628 H H    . PHE B 2 18  ? -4.55086  14.21235  -12.42997 1.000 26.94842 ? 540  PHE B H    1 
ATOM   3629 H HA   . PHE B 2 18  ? -2.26195  14.18796  -11.02536 1.000 22.34875 ? 540  PHE B HA   1 
ATOM   3630 H HB2  . PHE B 2 18  ? -4.37591  13.92637  -9.95833  1.000 21.94312 ? 540  PHE B HB2  1 
ATOM   3631 H HB3  . PHE B 2 18  ? -4.57107  12.55755  -10.74171 1.000 21.94312 ? 540  PHE B HB3  1 
ATOM   3632 H HD1  . PHE B 2 18  ? -2.74445  14.07502  -8.20042  1.000 28.33476 ? 540  PHE B HD1  1 
ATOM   3633 H HD2  . PHE B 2 18  ? -3.51890  10.57850  -9.96338  1.000 23.57501 ? 540  PHE B HD2  1 
ATOM   3634 H HE1  . PHE B 2 18  ? -1.70610  12.96988  -6.45052  1.000 30.54965 ? 540  PHE B HE1  1 
ATOM   3635 H HE2  . PHE B 2 18  ? -2.48561  9.46529   -8.20120  1.000 24.57512 ? 540  PHE B HE2  1 
ATOM   3636 H HZ   . PHE B 2 18  ? -1.56378  10.66871  -6.46100  1.000 31.66913 ? 540  PHE B HZ   1 
ATOM   3637 N N    . GLN B 2 19  ? -1.00968  12.18809  -11.74637 1.000 18.98266 ? 541  GLN B N    1 
ATOM   3638 C CA   . GLN B 2 19  ? -0.27481  11.07163  -12.34405 1.000 20.06892 ? 541  GLN B CA   1 
ATOM   3639 C C    . GLN B 2 19  ? -0.20002  9.91571   -11.35392 1.000 19.46027 ? 541  GLN B C    1 
ATOM   3640 O O    . GLN B 2 19  ? 0.18146   10.10198  -10.19510 1.000 17.47738 ? 541  GLN B O    1 
ATOM   3641 C CB   . GLN B 2 19  ? 1.13360   11.49988  -12.76998 1.000 22.98840 ? 541  GLN B CB   1 
ATOM   3642 C CG   . GLN B 2 19  ? 1.17557   12.67881  -13.74815 1.000 28.45529 ? 541  GLN B CG   1 
ATOM   3643 C CD   . GLN B 2 19  ? 0.42352   12.45251  -15.03512 1.000 32.79536 ? 541  GLN B CD   1 
ATOM   3644 O OE1  . GLN B 2 19  ? 0.74852   11.55336  -15.81092 1.000 39.38367 ? 541  GLN B OE1  1 
ATOM   3645 N NE2  . GLN B 2 19  ? -0.59807  13.26023  -15.26679 1.000 35.25596 ? 541  GLN B NE2  1 
ATOM   3646 H H    . GLN B 2 19  ? -0.54370  12.67101  -11.20855 1.000 22.77920 ? 541  GLN B H    1 
ATOM   3647 H HA   . GLN B 2 19  ? -0.74768  10.76611  -13.13396 1.000 24.08270 ? 541  GLN B HA   1 
ATOM   3648 H HB2  . GLN B 2 19  ? 1.62952   11.75966  -11.97784 1.000 27.58608 ? 541  GLN B HB2  1 
ATOM   3649 H HB3  . GLN B 2 19  ? 1.56754   10.74700  -13.20099 1.000 27.58608 ? 541  GLN B HB3  1 
ATOM   3650 H HG2  . GLN B 2 19  ? 0.78613   13.45422  -13.31460 1.000 34.14635 ? 541  GLN B HG2  1 
ATOM   3651 H HG3  . GLN B 2 19  ? 2.10096   12.85704  -13.97793 1.000 34.14635 ? 541  GLN B HG3  1 
ATOM   3652 H HE21 . GLN B 2 19  ? -0.80004  13.87228  -14.69740 1.000 42.30715 ? 541  GLN B HE21 1 
ATOM   3653 H HE22 . GLN B 2 19  ? -1.06028  13.17332  -15.98679 1.000 42.30715 ? 541  GLN B HE22 1 
ATOM   3654 N N    . LEU B 2 20  ? -0.54223  8.72116   -11.82763 1.000 19.19287 ? 542  LEU B N    1 
ATOM   3655 C CA   . LEU B 2 20  ? -0.61274  7.53674   -10.97986 1.000 18.69517 ? 542  LEU B CA   1 
ATOM   3656 C C    . LEU B 2 20  ? 0.72789   6.88114   -10.79921 1.000 20.40945 ? 542  LEU B C    1 
ATOM   3657 O O    . LEU B 2 20  ? 0.83507   6.12347   -9.83197  1.000 21.20634 ? 542  LEU B O    1 
ATOM   3658 C CB   . LEU B 2 20  ? -1.57534  6.50191   -11.57466 1.000 19.92542 ? 542  LEU B CB   1 
ATOM   3659 C CG   . LEU B 2 20  ? -3.02881  6.98834   -11.64636 1.000 21.62948 ? 542  LEU B CG   1 
ATOM   3660 C CD1  . LEU B 2 20  ? -3.84223  5.93140   -12.34516 1.000 24.80457 ? 542  LEU B CD1  1 
ATOM   3661 C CD2  . LEU B 2 20  ? -3.57224  7.26867   -10.28210 1.000 24.44927 ? 542  LEU B CD2  1 
ATOM   3662 O OXT  . LEU B 2 20  ? 1.68331   7.06594   -11.58391 1.000 21.13393 ? 542  LEU B OXT  1 
ATOM   3663 H H    . LEU B 2 20  ? -0.74146  8.56839   -12.65017 1.000 23.03144 ? 542  LEU B H    1 
ATOM   3664 H HA   . LEU B 2 20  ? -0.93471  7.82294   -10.11076 1.000 22.43421 ? 542  LEU B HA   1 
ATOM   3665 H HB2  . LEU B 2 20  ? -1.28741  6.28982   -12.47633 1.000 23.91051 ? 542  LEU B HB2  1 
ATOM   3666 H HB3  . LEU B 2 20  ? -1.55516  5.70389   -11.02360 1.000 23.91051 ? 542  LEU B HB3  1 
ATOM   3667 H HG   . LEU B 2 20  ? -3.08189  7.82114   -12.14085 1.000 25.95538 ? 542  LEU B HG   1 
ATOM   3668 H HD11 . LEU B 2 20  ? -4.76049  6.23561   -12.41687 1.000 29.76548 ? 542  LEU B HD11 1 
ATOM   3669 H HD12 . LEU B 2 20  ? -3.47313  5.78230   -13.22971 1.000 29.76548 ? 542  LEU B HD12 1 
ATOM   3670 H HD13 . LEU B 2 20  ? -3.80487  5.11124   -11.82859 1.000 29.76548 ? 542  LEU B HD13 1 
ATOM   3671 H HD21 . LEU B 2 20  ? -4.53202  7.39462   -10.34421 1.000 29.33912 ? 542  LEU B HD21 1 
ATOM   3672 H HD22 . LEU B 2 20  ? -3.37415  6.51648   -9.70256  1.000 29.33912 ? 542  LEU B HD22 1 
ATOM   3673 H HD23 . LEU B 2 20  ? -3.15491  8.07257   -9.93498  1.000 29.33912 ? 542  LEU B HD23 1 
HETATM 3674 C C    . ACT C 3 .   ? -32.34665 18.48671  -13.68349 1.000 15.01270 ? 801  ACT A C    1 
HETATM 3675 O O    . ACT C 3 .   ? -31.52700 18.77858  -14.65756 1.000 34.27722 ? 801  ACT A O    1 
HETATM 3676 O OXT  . ACT C 3 .   ? -33.36513 17.80004  -13.70806 1.000 48.56840 ? 801  ACT A OXT  1 
HETATM 3677 C CH3  . ACT C 3 .   ? -31.95805 18.86863  -12.36737 1.000 19.08061 ? 801  ACT A CH3  1 
HETATM 3678 H H1   . ACT C 3 .   ? -32.16659 19.80571  -12.22849 1.000 22.89673 ? 801  ACT A H1   1 
HETATM 3679 H H2   . ACT C 3 .   ? -31.00417 18.72953  -12.25941 1.000 22.89673 ? 801  ACT A H2   1 
HETATM 3680 H H3   . ACT C 3 .   ? -32.43932 18.33018  -11.71979 1.000 22.89673 ? 801  ACT A H3   1 
HETATM 3681 C C    . ACT D 3 .   ? -23.90898 9.62094   -10.21342 1.000 14.55281 ? 802  ACT A C    1 
HETATM 3682 O O    . ACT D 3 .   ? -24.54239 8.55195   -10.18996 1.000 15.03958 ? 802  ACT A O    1 
HETATM 3683 O OXT  . ACT D 3 .   ? -23.71645 10.39318  -9.26098  1.000 16.49495 ? 802  ACT A OXT  1 
HETATM 3684 C CH3  . ACT D 3 .   ? -23.31077 10.10021  -11.55723 1.000 17.24323 ? 802  ACT A CH3  1 
HETATM 3685 H H1   . ACT D 3 .   ? -23.74289 10.92579  -11.82663 1.000 20.69187 ? 802  ACT A H1   1 
HETATM 3686 H H2   . ACT D 3 .   ? -23.45631 9.42208   -12.23536 1.000 20.69187 ? 802  ACT A H2   1 
HETATM 3687 H H3   . ACT D 3 .   ? -22.35878 10.25264  -11.45056 1.000 20.69187 ? 802  ACT A H3   1 
HETATM 3688 O O    . HOH E 4 .   ? -26.45253 23.17000  -25.62064 1.000 56.41855 ? 901  HOH A O    1 
HETATM 3689 O O    . HOH E 4 .   ? -2.94730  4.77111   -4.12494  1.000 28.60929 ? 902  HOH A O    1 
HETATM 3690 O O    . HOH E 4 .   ? -10.66461 14.95192  8.01599   1.000 39.28796 ? 903  HOH A O    1 
HETATM 3691 O O    . HOH E 4 .   ? -28.90538 9.04773   2.59855   1.000 26.65258 ? 904  HOH A O    1 
HETATM 3692 O O    . HOH E 4 .   ? -27.94025 6.33822   -27.10330 1.000 49.21275 ? 905  HOH A O    1 
HETATM 3693 O O    . HOH E 4 .   ? -12.21037 13.59036  8.55834   1.000 43.88818 ? 906  HOH A O    1 
HETATM 3694 O O    . HOH E 4 .   ? -8.83100  5.74602   -26.19858 1.000 35.03788 ? 907  HOH A O    1 
HETATM 3695 O O    . HOH E 4 .   ? -2.87773  10.88982  -19.11469 1.000 36.17568 ? 908  HOH A O    1 
HETATM 3696 O O    . HOH E 4 .   ? -12.86040 4.63646   -25.49052 1.000 31.35799 ? 909  HOH A O    1 
HETATM 3697 O O    . HOH E 4 .   ? -25.73301 27.46430  -13.76750 1.000 31.85407 ? 910  HOH A O    1 
HETATM 3698 O O    . HOH E 4 .   ? -36.00197 1.09371   -2.22166  1.000 36.37318 ? 911  HOH A O    1 
HETATM 3699 O O    . HOH E 4 .   ? -20.32027 -1.22079  4.16482   1.000 23.64688 ? 912  HOH A O    1 
HETATM 3700 O O    . HOH E 4 .   ? -1.07224  0.88906   -5.91825  1.000 24.77150 ? 913  HOH A O    1 
HETATM 3701 O O    . HOH E 4 .   ? -4.41354  3.27670   -0.28285  1.000 37.32696 ? 914  HOH A O    1 
HETATM 3702 O O    . HOH E 4 .   ? -8.37863  12.51650  -28.39236 1.000 35.99628 ? 915  HOH A O    1 
HETATM 3703 O O    . HOH E 4 .   ? -19.37479 4.77732   11.63514  1.000 35.20478 ? 916  HOH A O    1 
HETATM 3704 O O    . HOH E 4 .   ? -37.23656 11.40740  0.06941   1.000 30.29257 ? 917  HOH A O    1 
HETATM 3705 O O    . HOH E 4 .   ? -9.16487  22.07445  -2.80248  1.000 36.76679 ? 918  HOH A O    1 
HETATM 3706 O O    . HOH E 4 .   ? -11.75899 -13.79460 -6.26347  1.000 33.04723 ? 919  HOH A O    1 
HETATM 3707 O O    . HOH E 4 .   ? -6.18765  -0.37413  -1.31125  1.000 27.68576 ? 920  HOH A O    1 
HETATM 3708 O O    . HOH E 4 .   ? -29.57031 0.02420   -2.81546  1.000 39.79064 ? 921  HOH A O    1 
HETATM 3709 O O    . HOH E 4 .   ? -22.52563 12.66747  -8.69140  1.000 19.89014 ? 922  HOH A O    1 
HETATM 3710 O O    . HOH E 4 .   ? -30.52081 -2.03764  -8.93682  1.000 45.89551 ? 923  HOH A O    1 
HETATM 3711 O O    . HOH E 4 .   ? -24.17692 5.19786   -27.42454 1.000 34.64112 ? 924  HOH A O    1 
HETATM 3712 O O    . HOH E 4 .   ? -5.87076  -1.06539  -19.18624 1.000 25.72738 ? 925  HOH A O    1 
HETATM 3713 O O    . HOH E 4 .   ? -21.52239 -5.68727  -13.98456 1.000 31.18632 ? 926  HOH A O    1 
HETATM 3714 O O    . HOH E 4 .   ? -30.37946 13.73262  -22.83046 1.000 24.74852 ? 927  HOH A O    1 
HETATM 3715 O O    . HOH E 4 .   ? -30.03662 19.47209  0.03414   1.000 36.72068 ? 928  HOH A O    1 
HETATM 3716 O O    . HOH E 4 .   ? -6.38748  15.28812  3.04991   1.000 30.97926 ? 929  HOH A O    1 
HETATM 3717 O O    . HOH E 4 .   ? -11.67185 22.81818  -4.23034  1.000 39.61045 ? 930  HOH A O    1 
HETATM 3718 O O    . HOH E 4 .   ? -27.64542 26.94532  -28.09520 1.000 31.24351 ? 931  HOH A O    1 
HETATM 3719 O O    . HOH E 4 .   ? -2.09286  8.99534   -30.48417 1.000 34.20087 ? 932  HOH A O    1 
HETATM 3720 O O    . HOH E 4 .   ? -15.833   11.980    -31.451   1.000 31.56971 ? 933  HOH A O    1 
HETATM 3721 O O    . HOH E 4 .   ? -19.40606 -8.63484  -23.78473 1.000 30.69636 ? 934  HOH A O    1 
HETATM 3722 O O    . HOH E 4 .   ? -32.03208 2.58388   -2.27660  1.000 30.88529 ? 935  HOH A O    1 
HETATM 3723 O O    . HOH E 4 .   ? -12.80694 21.80740  -2.77674  1.000 36.90818 ? 936  HOH A O    1 
HETATM 3724 O O    . HOH E 4 .   ? -14.99820 9.39354   -26.66770 1.000 24.28407 ? 937  HOH A O    1 
HETATM 3725 O O    . HOH E 4 .   ? -30.29751 -2.01338  -25.50024 1.000 36.79442 ? 938  HOH A O    1 
HETATM 3726 O O    . HOH E 4 .   ? -5.49353  10.91522  3.06839   1.000 35.00973 ? 939  HOH A O    1 
HETATM 3727 O O    . HOH E 4 .   ? -27.91558 22.36673  -7.47768  1.000 33.93026 ? 940  HOH A O    1 
HETATM 3728 O O    . HOH E 4 .   ? -33.14940 -2.45484  -13.50665 1.000 33.12071 ? 941  HOH A O    1 
HETATM 3729 O O    . HOH E 4 .   ? -2.250    -5.565    -14.354   1.000 36.79152 ? 942  HOH A O    1 
HETATM 3730 O O    . HOH E 4 .   ? -34.08792 8.16261   1.21873   1.000 24.90361 ? 943  HOH A O    1 
HETATM 3731 O O    . HOH E 4 .   ? -8.95005  -16.81584 -6.03750  1.000 26.27406 ? 944  HOH A O    1 
HETATM 3732 O O    . HOH E 4 .   ? -19.88128 11.41885  -12.24508 1.000 17.39777 ? 945  HOH A O    1 
HETATM 3733 O O    . HOH E 4 .   ? 0.81231   9.09529   -26.55377 1.000 40.26201 ? 946  HOH A O    1 
HETATM 3734 O O    . HOH E 4 .   ? -25.15441 24.45401  -20.34210 1.000 20.81457 ? 947  HOH A O    1 
HETATM 3735 O O    . HOH E 4 .   ? -17.36056 6.60663   11.14236  1.000 34.40406 ? 948  HOH A O    1 
HETATM 3736 O O    . HOH E 4 .   ? -20.95630 24.54683  -18.54843 1.000 18.43573 ? 949  HOH A O    1 
HETATM 3737 O O    . HOH E 4 .   ? -23.06884 14.29218  -11.11251 1.000 16.12054 ? 950  HOH A O    1 
HETATM 3738 O O    . HOH E 4 .   ? -19.75185 12.55444  -8.16287  1.000 16.07992 ? 951  HOH A O    1 
HETATM 3739 O O    . HOH E 4 .   ? -35.18464 21.51093  -16.89147 1.000 27.67758 ? 952  HOH A O    1 
HETATM 3740 O O    . HOH E 4 .   ? -22.17202 9.04913   4.71358   1.000 34.72375 ? 953  HOH A O    1 
HETATM 3741 O O    . HOH E 4 .   ? -13.14757 17.49562  -21.74386 1.000 26.93733 ? 954  HOH A O    1 
HETATM 3742 O O    . HOH E 4 .   ? -5.71215  -12.78306 -7.73933  1.000 33.41529 ? 955  HOH A O    1 
HETATM 3743 O O    . HOH E 4 .   ? -12.92153 -3.44320  -0.58829  1.000 35.05238 ? 956  HOH A O    1 
HETATM 3744 O O    . HOH E 4 .   ? -19.61337 26.18042  -11.18014 1.000 25.23845 ? 957  HOH A O    1 
HETATM 3745 O O    . HOH E 4 .   ? -37.53388 22.35395  -1.10947  1.000 21.63860 ? 958  HOH A O    1 
HETATM 3746 O O    . HOH E 4 .   ? -15.11861 25.13051  -4.19253  1.000 28.48551 ? 959  HOH A O    1 
HETATM 3747 O O    . HOH E 4 .   ? -36.38901 9.29235   -9.59125  1.000 22.25106 ? 960  HOH A O    1 
HETATM 3748 O O    . HOH E 4 .   ? -7.72371  -10.50784 -14.82855 1.000 26.34165 ? 961  HOH A O    1 
HETATM 3749 O O    . HOH E 4 .   ? -26.76068 16.44414  4.15629   1.000 27.40982 ? 962  HOH A O    1 
HETATM 3750 O O    . HOH E 4 .   ? -14.49234 18.52808  4.93110   1.000 25.35478 ? 963  HOH A O    1 
HETATM 3751 O O    . HOH E 4 .   ? -33.40162 24.76040  -15.00590 1.000 35.05358 ? 964  HOH A O    1 
HETATM 3752 O O    . HOH E 4 .   ? -2.56620  7.22368   -5.65633  1.000 23.73110 ? 965  HOH A O    1 
HETATM 3753 O O    . HOH E 4 .   ? -25.58158 23.00613  -13.33330 1.000 18.73057 ? 966  HOH A O    1 
HETATM 3754 O O    . HOH E 4 .   ? -27.28375 11.31704  1.66917   1.000 23.78160 ? 967  HOH A O    1 
HETATM 3755 O O    . HOH E 4 .   ? -14.26450 1.28181   7.58215   1.000 23.05836 ? 968  HOH A O    1 
HETATM 3756 O O    . HOH E 4 .   ? -26.57798 22.96063  -10.66207 1.000 24.44774 ? 969  HOH A O    1 
HETATM 3757 O O    . HOH E 4 .   ? -34.81011 6.94583   -9.44937  1.000 20.92140 ? 970  HOH A O    1 
HETATM 3758 O O    . HOH E 4 .   ? -31.74821 26.75381  -20.87760 1.000 24.94931 ? 971  HOH A O    1 
HETATM 3759 O O    . HOH E 4 .   ? -33.03726 20.02638  -0.55470  1.000 28.72016 ? 972  HOH A O    1 
HETATM 3760 O O    . HOH E 4 .   ? -31.63180 21.72462  -12.10097 1.000 25.81640 ? 973  HOH A O    1 
HETATM 3761 O O    . HOH E 4 .   ? -6.32640  1.87755   0.45023   1.000 31.55863 ? 974  HOH A O    1 
HETATM 3762 O O    . HOH E 4 .   ? -20.99572 -1.19002  -21.19910 1.000 17.02069 ? 975  HOH A O    1 
HETATM 3763 O O    . HOH E 4 .   ? -20.76793 -7.25308  1.15080   1.000 42.68664 ? 976  HOH A O    1 
HETATM 3764 O O    . HOH E 4 .   ? -22.92476 11.42380  -14.76951 1.000 18.87730 ? 977  HOH A O    1 
HETATM 3765 O O    . HOH E 4 .   ? -20.05703 -6.19118  -4.43625  1.000 34.62098 ? 978  HOH A O    1 
HETATM 3766 O O    . HOH E 4 .   ? -4.81154  12.36618  -4.81018  1.000 33.97986 ? 979  HOH A O    1 
HETATM 3767 O O    . HOH E 4 .   ? -34.18646 19.34503  -18.10786 1.000 29.86041 ? 980  HOH A O    1 
HETATM 3768 O O    . HOH E 4 .   ? 1.68093   8.25767   -14.31175 1.000 22.41844 ? 981  HOH A O    1 
HETATM 3769 O O    . HOH E 4 .   ? 1.95955   5.79356   -24.67445 1.000 39.04554 ? 982  HOH A O    1 
HETATM 3770 O O    . HOH E 4 .   ? -0.61572  -5.84168  -4.05505  1.000 25.53675 ? 983  HOH A O    1 
HETATM 3771 O O    . HOH E 4 .   ? -33.04395 -0.35857  -8.57917  1.000 33.66376 ? 984  HOH A O    1 
HETATM 3772 O O    . HOH E 4 .   ? -4.21058  0.74446   -14.94270 1.000 26.87433 ? 985  HOH A O    1 
HETATM 3773 O O    . HOH E 4 .   ? -26.75822 10.27392  -24.48405 1.000 33.04069 ? 986  HOH A O    1 
HETATM 3774 O O    . HOH E 4 .   ? -20.59339 7.50636   -20.50497 1.000 15.72667 ? 987  HOH A O    1 
HETATM 3775 O O    . HOH E 4 .   ? -1.33145  11.15774  -21.45120 1.000 27.15118 ? 988  HOH A O    1 
HETATM 3776 O O    . HOH E 4 .   ? -30.43114 12.26006  2.16370   1.000 29.57521 ? 989  HOH A O    1 
HETATM 3777 O O    . HOH E 4 .   ? -10.18627 -2.79366  -2.23059  1.000 29.89223 ? 990  HOH A O    1 
HETATM 3778 O O    . HOH E 4 .   ? -1.33444  10.26458  -28.27138 1.000 28.89432 ? 991  HOH A O    1 
HETATM 3779 O O    . HOH E 4 .   ? -11.54341 1.64326   5.12455   1.000 29.64840 ? 992  HOH A O    1 
HETATM 3780 O O    . HOH E 4 .   ? -14.14034 21.75581  -21.66801 1.000 23.22054 ? 993  HOH A O    1 
HETATM 3781 O O    . HOH E 4 .   ? -19.94708 17.13325  8.77572   1.000 26.78304 ? 994  HOH A O    1 
HETATM 3782 O O    . HOH E 4 .   ? -1.81601  2.98399   -13.52458 1.000 22.14132 ? 995  HOH A O    1 
HETATM 3783 O O    . HOH E 4 .   ? -9.26437  18.68291  -26.40205 1.000 32.93751 ? 996  HOH A O    1 
HETATM 3784 O O    . HOH E 4 .   ? -36.74305 4.24149   -11.75585 1.000 32.91174 ? 997  HOH A O    1 
HETATM 3785 O O    . HOH E 4 .   ? -27.46477 2.80155   -25.18378 1.000 27.61008 ? 998  HOH A O    1 
HETATM 3786 O O    . HOH E 4 .   ? -36.46181 17.30689  -1.91360  1.000 30.49324 ? 999  HOH A O    1 
HETATM 3787 O O    . HOH E 4 .   ? -32.00142 3.83510   7.47316   1.000 45.12391 ? 1000 HOH A O    1 
HETATM 3788 O O    . HOH E 4 .   ? -22.99725 26.10684  -2.27320  1.000 24.78492 ? 1001 HOH A O    1 
HETATM 3789 O O    . HOH E 4 .   ? -17.24336 -3.09347  -24.93443 1.000 33.88571 ? 1002 HOH A O    1 
HETATM 3790 O O    . HOH E 4 .   ? -14.60200 23.35769  4.12634   1.000 39.43464 ? 1003 HOH A O    1 
HETATM 3791 O O    . HOH E 4 .   ? -0.59802  -4.01517  -12.62417 1.000 24.91450 ? 1004 HOH A O    1 
HETATM 3792 O O    . HOH E 4 .   ? -25.25833 24.59805  -23.83196 1.000 30.16037 ? 1005 HOH A O    1 
HETATM 3793 O O    . HOH E 4 .   ? -14.34884 4.32066   -22.26480 1.000 15.83959 ? 1006 HOH A O    1 
HETATM 3794 O O    . HOH E 4 .   ? -28.99946 30.34661  -20.44556 1.000 32.03388 ? 1007 HOH A O    1 
HETATM 3795 O O    . HOH E 4 .   ? -18.21390 -2.04928  7.99774   1.000 37.02271 ? 1008 HOH A O    1 
HETATM 3796 O O    . HOH E 4 .   ? -6.71934  -2.96111  0.09894   1.000 37.97404 ? 1009 HOH A O    1 
HETATM 3797 O O    . HOH E 4 .   ? -2.72850  4.68856   -24.06022 1.000 27.46963 ? 1010 HOH A O    1 
HETATM 3798 O O    . HOH E 4 .   ? -6.00609  14.59338  -7.36708  1.000 22.78624 ? 1011 HOH A O    1 
HETATM 3799 O O    . HOH E 4 .   ? -22.46873 -0.91354  -0.61066  1.000 21.31448 ? 1012 HOH A O    1 
HETATM 3800 O O    . HOH E 4 .   ? -26.13730 8.78855   -26.56698 1.000 33.95042 ? 1013 HOH A O    1 
HETATM 3801 O O    . HOH E 4 .   ? -9.70864  -9.12610  -2.51218  1.000 27.55027 ? 1014 HOH A O    1 
HETATM 3802 O O    . HOH E 4 .   ? -8.00744  21.71199  -11.11065 1.000 25.77926 ? 1015 HOH A O    1 
HETATM 3803 O O    . HOH E 4 .   ? -37.40579 16.43143  -11.89713 1.000 32.35240 ? 1016 HOH A O    1 
HETATM 3804 O O    . HOH E 4 .   ? -34.82309 0.13130   -10.67596 1.000 30.70262 ? 1017 HOH A O    1 
HETATM 3805 O O    . HOH E 4 .   ? -20.71782 9.82301   -14.36735 1.000 16.67706 ? 1018 HOH A O    1 
HETATM 3806 O O    . HOH E 4 .   ? -21.02114 -5.67058  -11.05970 1.000 21.46970 ? 1019 HOH A O    1 
HETATM 3807 O O    . HOH E 4 .   ? -8.29172  25.03297  -27.24787 1.000 41.81487 ? 1020 HOH A O    1 
HETATM 3808 O O    . HOH E 4 .   ? -21.87068 24.06435  -0.68540  1.000 20.10998 ? 1021 HOH A O    1 
HETATM 3809 O O    . HOH E 4 .   ? -30.46533 -3.07917  -12.99286 1.000 30.13881 ? 1022 HOH A O    1 
HETATM 3810 O O    . HOH E 4 .   ? -4.47891  15.62246  -31.23740 1.000 32.58233 ? 1023 HOH A O    1 
HETATM 3811 O O    . HOH E 4 .   ? -31.636   29.321    -26.724   1.000 33.11876 ? 1024 HOH A O    1 
HETATM 3812 O O    . HOH E 4 .   ? 0.58023   25.25036  -29.18421 1.000 27.69420 ? 1025 HOH A O    1 
HETATM 3813 O O    . HOH E 4 .   ? -12.69246 -4.30595  -22.99190 1.000 27.90519 ? 1026 HOH A O    1 
HETATM 3814 O O    . HOH E 4 .   ? -25.32972 26.21501  -3.56328  1.000 28.33658 ? 1027 HOH A O    1 
HETATM 3815 O O    . HOH E 4 .   ? -28.75297 -0.82546  -7.47073  1.000 22.65934 ? 1028 HOH A O    1 
HETATM 3816 O O    . HOH E 4 .   ? -12.06435 6.53074   -23.86841 1.000 29.43616 ? 1029 HOH A O    1 
HETATM 3817 O O    . HOH E 4 .   ? -21.45780 -6.60313  -6.65156  1.000 42.46032 ? 1030 HOH A O    1 
HETATM 3818 O O    . HOH E 4 .   ? -2.205    27.289    -26.007   1.000 38.06478 ? 1031 HOH A O    1 
HETATM 3819 O O    . HOH E 4 .   ? -15.95690 2.39813   -27.76848 1.000 30.34887 ? 1032 HOH A O    1 
HETATM 3820 O O    . HOH E 4 .   ? -8.54360  11.01286  -30.15897 1.000 33.99352 ? 1033 HOH A O    1 
HETATM 3821 O O    . HOH E 4 .   ? -8.73930  17.29069  -12.63383 1.000 18.28791 ? 1034 HOH A O    1 
HETATM 3822 O O    . HOH E 4 .   ? -15.71682 14.40229  -24.83334 1.000 22.55672 ? 1035 HOH A O    1 
HETATM 3823 O O    . HOH E 4 .   ? -24.49464 12.81631  -6.16143  1.000 20.04470 ? 1036 HOH A O    1 
HETATM 3824 O O    . HOH E 4 .   ? -5.04405  -12.10115 -14.38536 1.000 38.70791 ? 1037 HOH A O    1 
HETATM 3825 O O    . HOH E 4 .   ? -25.96529 11.99017  3.87967   1.000 35.34708 ? 1038 HOH A O    1 
HETATM 3826 O O    . HOH E 4 .   ? -12.34105 -14.37908 -12.25644 1.000 25.60162 ? 1039 HOH A O    1 
HETATM 3827 O O    . HOH E 4 .   ? -23.79947 -0.77531  2.38424   1.000 33.34575 ? 1040 HOH A O    1 
HETATM 3828 O O    . HOH E 4 .   ? -22.840   3.717     13.000    1.000 41.21149 ? 1041 HOH A O    1 
HETATM 3829 O O    . HOH E 4 .   ? -17.09496 -4.07424  -22.22009 1.000 24.39713 ? 1042 HOH A O    1 
HETATM 3830 O O    . HOH E 4 .   ? -8.35537  -0.46333  -2.77459  1.000 24.31371 ? 1043 HOH A O    1 
HETATM 3831 O O    . HOH E 4 .   ? -16.35606 28.73409  1.23687   1.000 36.83691 ? 1044 HOH A O    1 
HETATM 3832 O O    . HOH E 4 .   ? -16.25961 -0.15010  9.72140   1.000 35.37610 ? 1045 HOH A O    1 
HETATM 3833 O O    . HOH E 4 .   ? -15.42827 23.93407  -24.53375 1.000 46.01867 ? 1046 HOH A O    1 
HETATM 3834 O O    . HOH E 4 .   ? -34.84279 21.20014  -9.02913  1.000 41.19869 ? 1047 HOH A O    1 
HETATM 3835 O O    . HOH E 4 .   ? -22.17169 15.59852  9.27863   1.000 32.87478 ? 1048 HOH A O    1 
HETATM 3836 O O    . HOH E 4 .   ? -25.76971 9.76658   4.53430   1.000 31.21038 ? 1049 HOH A O    1 
HETATM 3837 O O    . HOH E 4 .   ? -5.23548  10.55675  -2.54003  1.000 33.95796 ? 1050 HOH A O    1 
HETATM 3838 O O    . HOH E 4 .   ? -10.48944 5.45856   7.75196   1.000 40.94755 ? 1051 HOH A O    1 
HETATM 3839 O O    . HOH E 4 .   ? -3.97818  21.98657  -9.04137  1.000 34.73435 ? 1052 HOH A O    1 
HETATM 3840 O O    . HOH E 4 .   ? -24.86265 27.71829  -17.32313 1.000 26.80923 ? 1053 HOH A O    1 
HETATM 3841 O O    . HOH E 4 .   ? -10.40835 -0.70966  -24.92893 1.000 30.61694 ? 1054 HOH A O    1 
HETATM 3842 O O    . HOH E 4 .   ? -29.92192 23.93288  -4.93262  1.000 43.08139 ? 1055 HOH A O    1 
HETATM 3843 O O    . HOH E 4 .   ? -23.58119 27.81269  -14.73994 1.000 26.89086 ? 1056 HOH A O    1 
HETATM 3844 O O    . HOH E 4 .   ? -30.17859 22.57613  -9.40489  1.000 31.54830 ? 1057 HOH A O    1 
HETATM 3845 O O    . HOH E 4 .   ? -3.92659  2.97011   -25.40127 1.000 39.40604 ? 1058 HOH A O    1 
HETATM 3846 O O    . HOH E 4 .   ? -4.407    -2.784    -22.127   1.000 30.32456 ? 1059 HOH A O    1 
HETATM 3847 O O    . HOH E 4 .   ? -27.46074 24.30105  -27.67124 1.000 34.89529 ? 1060 HOH A O    1 
HETATM 3848 O O    . HOH E 4 .   ? -29.03433 -0.88999  -22.25256 1.000 22.34944 ? 1061 HOH A O    1 
HETATM 3849 O O    . HOH E 4 .   ? -15.12914 9.61149   -29.64610 1.000 33.95535 ? 1062 HOH A O    1 
HETATM 3850 O O    . HOH E 4 .   ? -24.27897 -7.78441  -27.29574 1.000 37.11220 ? 1063 HOH A O    1 
HETATM 3851 O O    . HOH E 4 .   ? -28.50084 -4.93267  -15.54133 1.000 42.97952 ? 1064 HOH A O    1 
HETATM 3852 O O    . HOH E 4 .   ? -36.67350 5.40205   -8.10150  1.000 27.62153 ? 1065 HOH A O    1 
HETATM 3853 O O    . HOH E 4 .   ? -17.60413 27.20315  -15.04814 1.000 34.04349 ? 1066 HOH A O    1 
HETATM 3854 O O    . HOH E 4 .   ? -12.97844 7.62869   -26.56709 1.000 28.42296 ? 1067 HOH A O    1 
HETATM 3855 O O    . HOH E 4 .   ? -33.201   3.758     5.178     1.000 37.34222 ? 1068 HOH A O    1 
HETATM 3856 O O    . HOH E 4 .   ? -3.99675  0.38185   -17.59153 1.000 26.60412 ? 1069 HOH A O    1 
HETATM 3857 O O    . HOH E 4 .   ? -18.28575 25.82721  -25.50786 1.000 31.38957 ? 1070 HOH A O    1 
HETATM 3858 O O    . HOH E 4 .   ? -35.88766 0.43718   -6.87553  1.000 47.31800 ? 1071 HOH A O    1 
HETATM 3859 O O    . HOH E 4 .   ? -3.17123  -6.76481  -3.00696  1.000 25.55347 ? 1072 HOH A O    1 
HETATM 3860 O O    . HOH E 4 .   ? -12.64590 -1.27651  -23.41898 1.000 28.48384 ? 1073 HOH A O    1 
HETATM 3861 O O    . HOH E 4 .   ? -33.13278 15.94390  1.76962   1.000 38.05964 ? 1074 HOH A O    1 
HETATM 3862 O O    . HOH E 4 .   ? -33.99627 -3.12354  -18.39620 1.000 25.66146 ? 1075 HOH A O    1 
HETATM 3863 O O    . HOH E 4 .   ? -14.23798 12.54458  8.91970   1.000 32.90800 ? 1076 HOH A O    1 
HETATM 3864 O O    . HOH E 4 .   ? -23.18238 8.98707   7.15762   1.000 36.82350 ? 1077 HOH A O    1 
HETATM 3865 O O    . HOH E 4 .   ? -4.75398  -7.59431  -21.90859 1.000 50.81685 ? 1078 HOH A O    1 
HETATM 3866 O O    . HOH E 4 .   ? -22.76446 28.21701  -8.43639  1.000 35.30728 ? 1079 HOH A O    1 
HETATM 3867 O O    . HOH E 4 .   ? -9.380    -13.573   -13.723   1.000 38.44166 ? 1080 HOH A O    1 
HETATM 3868 O O    . HOH E 4 .   ? -11.10619 -10.14915 -18.76736 1.000 23.38707 ? 1081 HOH A O    1 
HETATM 3869 O O    . HOH E 4 .   ? -29.207   26.554    -3.032    1.000 32.45856 ? 1082 HOH A O    1 
HETATM 3870 O O    . HOH E 4 .   ? -5.06457  -10.39978 -3.30134  1.000 30.74922 ? 1083 HOH A O    1 
HETATM 3871 O O    . HOH E 4 .   ? -23.91019 12.66812  -31.41428 1.000 38.36199 ? 1084 HOH A O    1 
HETATM 3872 O O    . HOH E 4 .   ? -28.42868 -1.01435  -27.34597 1.000 46.11974 ? 1085 HOH A O    1 
HETATM 3873 O O    . HOH E 4 .   ? -15.639   15.882    -33.471   1.000 38.64659 ? 1086 HOH A O    1 
HETATM 3874 O O    . HOH E 4 .   ? -19.78008 -4.67173  -22.68796 1.000 29.75249 ? 1087 HOH A O    1 
HETATM 3875 O O    . HOH E 4 .   ? -32.80871 12.81226  -15.85984 1.000 37.98930 ? 1088 HOH A O    1 
HETATM 3876 O O    . HOH E 4 .   ? -21.27753 -2.27112  -23.69445 1.000 33.97307 ? 1089 HOH A O    1 
HETATM 3877 O O    . HOH E 4 .   ? -28.23356 11.91819  -24.96088 1.000 37.17759 ? 1090 HOH A O    1 
HETATM 3878 O O    . HOH E 4 .   ? -15.90245 -11.87083 -22.63310 1.000 39.06454 ? 1091 HOH A O    1 
HETATM 3879 O O    . HOH E 4 .   ? -29.38201 2.44696   -0.96698  1.000 29.37293 ? 1092 HOH A O    1 
HETATM 3880 O O    . HOH E 4 .   ? -39.91284 11.61300  -1.27803  1.000 35.02083 ? 1093 HOH A O    1 
HETATM 3881 O O    . HOH E 4 .   ? -12.36745 -10.88222 -6.40559  1.000 25.46016 ? 1094 HOH A O    1 
HETATM 3882 O O    . HOH E 4 .   ? -10.67895 -16.00376 -10.63831 1.000 22.97893 ? 1095 HOH A O    1 
HETATM 3883 O O    . HOH E 4 .   ? -4.62376  8.56497   1.40589   1.000 36.23144 ? 1096 HOH A O    1 
HETATM 3884 O O    . HOH E 4 .   ? -14.16376 17.84423  7.78406   1.000 38.87293 ? 1097 HOH A O    1 
HETATM 3885 O O    . HOH E 4 .   ? -16.15916 28.38123  -1.84152  1.000 38.70564 ? 1098 HOH A O    1 
HETATM 3886 O O    . HOH E 4 .   ? -0.59046  15.63427  -19.57665 1.000 47.76283 ? 1099 HOH A O    1 
HETATM 3887 O O    . HOH E 4 .   ? -24.24176 26.04553  -6.06083  1.000 32.86394 ? 1100 HOH A O    1 
HETATM 3888 O O    . HOH E 4 .   ? -29.13490 18.22048  3.96467   1.000 34.51534 ? 1101 HOH A O    1 
HETATM 3889 O O    . HOH E 4 .   ? -17.690   17.093    -32.307   1.000 36.85546 ? 1102 HOH A O    1 
HETATM 3890 O O    . HOH E 4 .   ? -11.61797 25.79288  -0.77119  1.000 45.18884 ? 1103 HOH A O    1 
HETATM 3891 O O    . HOH E 4 .   ? -21.140   -9.546    -11.156   1.000 32.33507 ? 1104 HOH A O    1 
HETATM 3892 O O    . HOH E 4 .   ? -14.41895 -3.33954  3.90601   1.000 39.25558 ? 1105 HOH A O    1 
HETATM 3893 O O    . HOH E 4 .   ? -21.85729 -8.61649  -13.47263 1.000 39.67397 ? 1106 HOH A O    1 
HETATM 3894 O O    . HOH E 4 .   ? -12.03030 -9.90463  -3.86643  1.000 27.14246 ? 1107 HOH A O    1 
HETATM 3895 O O    . HOH E 4 .   ? -21.166   1.844     -28.294   1.000 39.19376 ? 1108 HOH A O    1 
HETATM 3896 O O    . HOH E 4 .   ? -36.97082 2.03381   -10.93454 1.000 41.58846 ? 1109 HOH A O    1 
HETATM 3897 O O    . HOH E 4 .   ? -14.10233 -10.28750 -21.86514 1.000 44.04276 ? 1110 HOH A O    1 
HETATM 3898 O O    . HOH E 4 .   ? -22.90781 28.59721  -1.09697  1.000 33.93017 ? 1111 HOH A O    1 
HETATM 3899 O O    . HOH E 4 .   ? -26.26038 -3.07887  -9.21291  1.000 40.87277 ? 1112 HOH A O    1 
HETATM 3900 O O    . HOH E 4 .   ? -32.06985 9.86454   2.30353   1.000 30.48281 ? 1113 HOH A O    1 
HETATM 3901 O O    . HOH E 4 .   ? -30.959   30.770    -16.161   1.000 52.64867 ? 1114 HOH A O    1 
HETATM 3902 O O    . HOH E 4 .   ? -4.65736  -12.77774 -5.09979  1.000 37.02696 ? 1115 HOH A O    1 
HETATM 3903 O O    . HOH E 4 .   ? -5.815    13.420    9.597     1.000 37.91632 ? 1116 HOH A O    1 
HETATM 3904 O O    . HOH E 4 .   ? -14.43314 -12.61606 -6.97660  1.000 38.66175 ? 1117 HOH A O    1 
HETATM 3905 O O    . HOH E 4 .   ? -24.66953 -4.88111  -7.81052  1.000 43.31605 ? 1118 HOH A O    1 
HETATM 3906 O O    . HOH E 4 .   ? -27.42423 10.13777  -28.60346 1.000 44.18628 ? 1119 HOH A O    1 
HETATM 3907 O O    . HOH E 4 .   ? -13.69027 20.89039  4.72272   1.000 39.17641 ? 1120 HOH A O    1 
HETATM 3908 O O    . HOH E 4 .   ? -22.21893 -0.40057  6.05437   1.000 33.24418 ? 1121 HOH A O    1 
HETATM 3909 O O    . HOH E 4 .   ? -17.99190 0.13747   12.49705  1.000 40.83530 ? 1122 HOH A O    1 
HETATM 3910 O O    . HOH E 4 .   ? -19.80887 -2.69272  -25.99241 1.000 32.80778 ? 1123 HOH A O    1 
HETATM 3911 O O    . HOH E 4 .   ? -0.924    8.443     -4.035    1.000 35.39909 ? 1124 HOH A O    1 
HETATM 3912 O O    . HOH E 4 .   ? -1.44485  13.77057  -20.76297 1.000 39.21079 ? 1125 HOH A O    1 
HETATM 3913 O O    . HOH E 4 .   ? -13.57984 26.66330  -2.51001  1.000 40.97339 ? 1126 HOH A O    1 
HETATM 3914 O O    . HOH E 4 .   ? -10.75932 17.06930  -25.74141 1.000 27.33729 ? 1127 HOH A O    1 
HETATM 3915 O O    . HOH E 4 .   ? -9.07803  -11.01249 -0.74653  1.000 44.53327 ? 1128 HOH A O    1 
HETATM 3916 O O    . HOH E 4 .   ? -36.10888 12.93098  2.54454   1.000 51.35404 ? 1129 HOH A O    1 
HETATM 3917 O O    . HOH E 4 .   ? -18.53308 2.89518   13.17195  1.000 42.49752 ? 1130 HOH A O    1 
HETATM 3918 O O    . HOH E 4 .   ? -10.54726 19.01850  -11.53238 1.000 31.93163 ? 1131 HOH A O    1 
HETATM 3919 O O    . HOH E 4 .   ? -26.00694 3.10272   -27.25054 1.000 36.39321 ? 1132 HOH A O    1 
HETATM 3920 O O    . HOH E 4 .   ? -27.36772 28.23645  -30.21815 1.000 41.21674 ? 1133 HOH A O    1 
HETATM 3921 O O    . HOH E 4 .   ? -12.98117 20.73113  -24.30728 1.000 30.08992 ? 1134 HOH A O    1 
HETATM 3922 O O    . HOH E 4 .   ? -35.82722 21.52365  -14.20474 1.000 47.07917 ? 1135 HOH A O    1 
HETATM 3923 O O    . HOH E 4 .   ? -24.05872 -4.40012  -15.15940 1.000 41.24561 ? 1136 HOH A O    1 
HETATM 3924 O O    . HOH E 4 .   ? -23.62380 -5.53988  -10.21001 1.000 35.21305 ? 1137 HOH A O    1 
HETATM 3925 O O    . HOH E 4 .   ? -3.70875  -13.41576 -9.73065  1.000 30.23754 ? 1138 HOH A O    1 
HETATM 3926 O O    . HOH E 4 .   ? -2.84373  -9.27832  -2.28601  1.000 32.78198 ? 1139 HOH A O    1 
HETATM 3927 O O    . HOH E 4 .   ? -24.76508 -4.80731  -17.39496 1.000 42.69691 ? 1140 HOH A O    1 
HETATM 3928 O O    . HOH E 4 .   ? -8.52089  1.79550   5.48134   1.000 40.41545 ? 1141 HOH A O    1 
HETATM 3929 O O    . HOH E 4 .   ? -4.71711  -13.18990 -12.26440 1.000 44.66503 ? 1142 HOH A O    1 
HETATM 3930 O O    . HOH E 4 .   ? -1.874    14.176    -31.414   1.000 33.66012 ? 1143 HOH A O    1 
HETATM 3931 O O    . HOH E 4 .   ? -11.98401 22.75300  -0.22727  1.000 37.08294 ? 1144 HOH A O    1 
HETATM 3932 O O    . HOH E 4 .   ? 0.05399   -11.21710 -3.78595  1.000 42.13629 ? 1145 HOH A O    1 
HETATM 3933 O O    . HOH F 4 .   ? -5.93443  19.25050  -16.56968 1.000 33.36882 ? 601  HOH B O    1 
HETATM 3934 O O    . HOH F 4 .   ? -10.21778 24.34086  -16.37654 1.000 43.52749 ? 602  HOH B O    1 
HETATM 3935 O O    . HOH F 4 .   ? -13.95579 19.55509  -20.02415 1.000 18.42832 ? 603  HOH B O    1 
HETATM 3936 O O    . HOH F 4 .   ? -24.02182 22.70953  -22.32478 1.000 18.15566 ? 604  HOH B O    1 
HETATM 3937 O O    . HOH F 4 .   ? -18.01738 17.98724  -13.75491 1.000 16.82478 ? 605  HOH B O    1 
HETATM 3938 O O    . HOH F 4 .   ? -10.56740 23.11858  -19.46518 1.000 33.23371 ? 606  HOH B O    1 
HETATM 3939 O O    . HOH F 4 .   ? -22.80185 13.53744  -23.33558 1.000 16.39247 ? 607  HOH B O    1 
HETATM 3940 O O    . HOH F 4 .   ? 1.15058   12.38940  -8.90501  1.000 25.59707 ? 608  HOH B O    1 
HETATM 3941 O O    . HOH F 4 .   ? -27.06804 21.04528  -27.00951 1.000 26.09195 ? 609  HOH B O    1 
HETATM 3942 O O    . HOH F 4 .   ? -11.21555 24.21927  -14.34099 1.000 32.77128 ? 610  HOH B O    1 
HETATM 3943 O O    . HOH F 4 .   ? -22.24991 14.30180  -30.52800 1.000 27.73714 ? 611  HOH B O    1 
HETATM 3944 O O    . HOH F 4 .   ? -8.75830  16.95411  -15.40967 1.000 17.12871 ? 612  HOH B O    1 
HETATM 3945 O O    . HOH F 4 .   ? -21.43077 13.48110  -13.31485 1.000 16.92499 ? 613  HOH B O    1 
HETATM 3946 O O    . HOH F 4 .   ? 0.34897   14.26145  -10.06316 1.000 33.12436 ? 614  HOH B O    1 
HETATM 3947 O O    . HOH F 4 .   ? -7.39363  23.82411  -16.29883 1.000 51.45484 ? 615  HOH B O    1 
HETATM 3948 O O    . HOH F 4 .   ? -15.15558 21.58165  -26.18543 1.000 38.76667 ? 616  HOH B O    1 
HETATM 3949 O O    . HOH F 4 .   ? -5.57477  17.53832  -12.14165 1.000 25.66410 ? 617  HOH B O    1 
HETATM 3950 O O    . HOH F 4 .   ? -13.263   26.268    -18.911   1.000 33.64013 ? 618  HOH B O    1 
HETATM 3951 O O    . HOH F 4 .   ? -12.91933 18.20808  -24.32659 1.000 26.91891 ? 619  HOH B O    1 
HETATM 3952 O O    . HOH F 4 .   ? -2.35343  22.42505  -19.98974 1.000 43.38852 ? 620  HOH B O    1 
HETATM 3953 O O    . HOH F 4 .   ? -4.65032  16.58685  -9.75704  1.000 33.78476 ? 621  HOH B O    1 
HETATM 3954 O O    . HOH F 4 .   ? -20.902   19.503    -33.544   1.000 33.40270 ? 622  HOH B O    1 
HETATM 3955 O O    . HOH F 4 .   ? -5.99442  19.96173  -13.01955 1.000 42.67327 ? 623  HOH B O    1 
HETATM 3956 O O    . HOH F 4 .   ? -16.01705 24.89460  -15.54362 1.000 31.97850 ? 624  HOH B O    1 
HETATM 3957 O O    . HOH F 4 .   ? -9.190    26.848    -16.927   1.000 32.43774 ? 625  HOH B O    1 
HETATM 3958 O O    . HOH F 4 .   ? -12.29361 23.56538  -21.44546 1.000 37.93771 ? 626  HOH B O    1 
HETATM 3959 O O    . HOH F 4 .   ? -28.34513 12.76695  -28.14565 1.000 48.65589 ? 627  HOH B O    1 
# 
loop_
_atom_site_anisotrop.id 
_atom_site_anisotrop.type_symbol 
_atom_site_anisotrop.pdbx_label_atom_id 
_atom_site_anisotrop.pdbx_label_alt_id 
_atom_site_anisotrop.pdbx_label_comp_id 
_atom_site_anisotrop.pdbx_label_asym_id 
_atom_site_anisotrop.pdbx_label_seq_id 
_atom_site_anisotrop.pdbx_PDB_ins_code 
_atom_site_anisotrop.U[1][1] 
_atom_site_anisotrop.U[2][2] 
_atom_site_anisotrop.U[3][3] 
_atom_site_anisotrop.U[1][2] 
_atom_site_anisotrop.U[1][3] 
_atom_site_anisotrop.U[2][3] 
_atom_site_anisotrop.pdbx_auth_seq_id 
_atom_site_anisotrop.pdbx_auth_comp_id 
_atom_site_anisotrop.pdbx_auth_asym_id 
_atom_site_anisotrop.pdbx_auth_atom_id 
1    N N   . LEU A 8   ? 0.45025 0.44094 0.31455 0.11333  -0.02766 0.05265  188 LEU A N   
2    C CA  . LEU A 8   ? 0.55559 0.53592 0.41154 0.12849  -0.02503 0.05681  188 LEU A CA  
3    C C   . LEU A 8   ? 0.37894 0.40646 0.26846 0.13014  -0.03971 0.04492  188 LEU A C   
4    O O   . LEU A 8   ? 0.38441 0.44695 0.30780 0.11105  -0.04450 0.03635  188 LEU A O   
5    C CB  . LEU A 8   ? 0.51916 0.47370 0.37935 0.11539  -0.00416 0.06593  188 LEU A CB  
8    N N   . PRO A 9   ? 0.37861 0.40624 0.25724 0.15312  -0.04593 0.04373  189 PRO A N   
9    C CA  . PRO A 9   ? 0.41648 0.49565 0.32986 0.15635  -0.05873 0.03007  189 PRO A CA  
10   C C   . PRO A 9   ? 0.31197 0.41366 0.26471 0.13035  -0.04848 0.02858  189 PRO A C   
11   O O   . PRO A 9   ? 0.31547 0.39042 0.26515 0.12315  -0.03371 0.03747  189 PRO A O   
12   C CB  . PRO A 9   ? 0.42778 0.48612 0.31933 0.17837  -0.05809 0.02878  189 PRO A CB  
13   C CG  . PRO A 9   ? 0.42384 0.43078 0.26702 0.19010  -0.05378 0.03566  189 PRO A CG  
14   C CD  . PRO A 9   ? 0.44657 0.42976 0.28327 0.17140  -0.04093 0.04756  189 PRO A CD  
22   N N   . ALA A 10  ? 0.27485 0.42532 0.26335 0.11608  -0.05632 0.01603  190 ALA A N   
23   C CA  . ALA A 10  ? 0.22566 0.39073 0.24367 0.08931  -0.04565 0.01542  190 ALA A CA  
24   C C   . ALA A 10  ? 0.19676 0.36826 0.22532 0.09544  -0.03852 0.01587  190 ALA A C   
25   O O   . ALA A 10  ? 0.20148 0.35856 0.23599 0.08047  -0.02606 0.02145  190 ALA A O   
26   C CB  . ALA A 10  ? 0.24425 0.45489 0.29293 0.07089  -0.05333 0.00199  190 ALA A CB  
32   N N   . LEU A 11  ? 0.25790 0.45206 0.28818 0.11934  -0.04771 0.00835  191 LEU A N   
33   C CA  . LEU A 11  ? 0.21573 0.42175 0.25781 0.12656  -0.04210 0.00601  191 LEU A CA  
34   C C   . LEU A 11  ? 0.24547 0.39814 0.26316 0.12838  -0.02924 0.01940  191 LEU A C   
35   O O   . LEU A 11  ? 0.23685 0.38846 0.26760 0.11442  -0.01887 0.02076  191 LEU A O   
36   C CB  . LEU A 11  ? 0.22380 0.45039 0.26334 0.15118  -0.05343 -0.00578 191 LEU A CB  
37   C CG  . LEU A 11  ? 0.32386 0.56188 0.37159 0.15988  -0.04876 -0.01148 191 LEU A CG  
38   C CD1 . LEU A 11  ? 0.44868 0.63282 0.46321 0.17515  -0.04180 0.00051  191 LEU A CD1 
39   C CD2 . LEU A 11  ? 0.34573 0.62087 0.43022 0.13601  -0.03877 -0.01617 191 LEU A CD2 
51   N N   . LYS A 12  ? 0.29722 0.40323 0.27724 0.14514  -0.02927 0.02864  192 LYS A N   
52   C CA  . LYS A 12  ? 0.27361 0.32834 0.23200 0.14352  -0.01559 0.03966  192 LYS A CA  
53   C C   . LYS A 12  ? 0.24427 0.28563 0.21397 0.11419  -0.00338 0.04509  192 LYS A C   
54   O O   . LYS A 12  ? 0.26279 0.28872 0.23776 0.10464  0.00623  0.04711  192 LYS A O   
55   C CB  . LYS A 12  ? 0.34075 0.34409 0.25224 0.16489  -0.01528 0.04873  192 LYS A CB  
56   C CG  . LYS A 12  ? 0.42928 0.37552 0.31686 0.16061  0.00092  0.05910  192 LYS A CG  
57   C CD  . LYS A 12  ? 0.51790 0.41460 0.35843 0.17449  0.00376  0.06297  192 LYS A CD  
64   N N   . LEU A 13  ? 0.23692 0.28254 0.20859 0.10173  -0.00482 0.04620  193 LEU A N   
65   C CA  . LEU A 13  ? 0.23228 0.26736 0.21388 0.07805  0.00469  0.04938  193 LEU A CA  
66   C C   . LEU A 13  ? 0.19531 0.25570 0.20499 0.06265  0.00614  0.04364  193 LEU A C   
67   O O   . LEU A 13  ? 0.19981 0.24456 0.21396 0.05170  0.01431  0.04537  193 LEU A O   
68   C CB  . LEU A 13  ? 0.24877 0.28794 0.22633 0.07128  0.00020  0.04933  193 LEU A CB  
69   C CG  . LEU A 13  ? 0.25144 0.27788 0.23487 0.05191  0.00862  0.05164  193 LEU A CG  
70   C CD1 . LEU A 13  ? 0.30619 0.29798 0.27860 0.05017  0.02272  0.05802  193 LEU A CD1 
71   C CD2 . LEU A 13  ? 0.28134 0.30934 0.25617 0.04930  0.00317  0.05081  193 LEU A CD2 
83   N N   . ALA A 14  ? 0.17912 0.27880 0.20682 0.06187  -0.00136 0.03574  194 ALA A N   
84   C CA  . ALA A 14  ? 0.14634 0.26716 0.19477 0.04714  0.00240  0.03102  194 ALA A CA  
85   C C   . ALA A 14  ? 0.16068 0.27359 0.20879 0.05566  0.00817  0.03103  194 ALA A C   
86   O O   . ALA A 14  ? 0.19546 0.29486 0.24569 0.04477  0.01468  0.03216  194 ALA A O   
87   C CB  . ALA A 14  ? 0.16879 0.33554 0.23720 0.04331  -0.00399 0.02138  194 ALA A CB  
93   N N   . LEU A 15  ? 0.16479 0.28437 0.20784 0.07710  0.00435  0.02854  195 LEU A N   
94   C CA  . LEU A 15  ? 0.17305 0.29139 0.21743 0.08577  0.00867  0.02587  195 LEU A CA  
95   C C   . LEU A 15  ? 0.22964 0.29901 0.25385 0.08901  0.01494  0.03242  195 LEU A C   
96   O O   . LEU A 15  ? 0.23490 0.29611 0.26103 0.08746  0.01965  0.03017  195 LEU A O   
97   C CB  . LEU A 15  ? 0.20124 0.34567 0.24700 0.11072  0.00131  0.01865  195 LEU A CB  
98   C CG  . LEU A 15  ? 0.19572 0.40085 0.27099 0.10669  -0.00313 0.00712  195 LEU A CG  
99   C CD1 . LEU A 15  ? 0.21041 0.44376 0.28936 0.13355  -0.01080 -0.00276 195 LEU A CD1 
100  C CD2 . LEU A 15  ? 0.21738 0.43953 0.31075 0.08372  0.00752  0.00473  195 LEU A CD2 
112  N N   . GLU A 16  ? 0.25229 0.28804 0.25585 0.09322  0.01587  0.03953  196 GLU A N   
113  C CA  . GLU A 16  ? 0.25385 0.24251 0.23830 0.09429  0.02397  0.04455  196 GLU A CA  
114  C C   . GLU A 16  ? 0.24241 0.21453 0.23342 0.07197  0.03187  0.04715  196 GLU A C   
115  O O   . GLU A 16  ? 0.29184 0.23136 0.27549 0.06695  0.03983  0.04818  196 GLU A O   
116  C CB  . GLU A 16  ? 0.31423 0.26858 0.26498 0.11440  0.02332  0.05079  196 GLU A CB  
117  C CG  . GLU A 16  ? 0.29494 0.26575 0.23730 0.14267  0.01273  0.04575  196 GLU A CG  
118  C CD  . GLU A 16  ? 0.37923 0.30504 0.27877 0.16741  0.01108  0.05174  196 GLU A CD  
119  O OE1 . GLU A 16  ? 0.44347 0.31777 0.31739 0.15876  0.02220  0.06021  196 GLU A OE1 
120  O OE2 . GLU A 16  ? 0.41132 0.35722 0.30430 0.18655  -0.00045 0.04416  196 GLU A OE2 
127  N N   . TYR A 17  ? 0.21818 0.21129 0.22251 0.05896  0.02963  0.04680  197 TYR A N   
128  C CA  . TYR A 17  ? 0.23476 0.21767 0.24708 0.04127  0.03529  0.04680  197 TYR A CA  
129  C C   . TYR A 17  ? 0.20696 0.21473 0.23760 0.02892  0.03084  0.04152  197 TYR A C   
130  O O   . TYR A 17  ? 0.22854 0.23152 0.26727 0.02142  0.03248  0.03705  197 TYR A O   
131  C CB  . TYR A 17  ? 0.24948 0.21858 0.24934 0.03974  0.03895  0.05251  197 TYR A CB  
132  C CG  . TYR A 17  ? 0.23245 0.19530 0.24294 0.02369  0.04570  0.05045  197 TYR A CG  
133  C CD1 . TYR A 17  ? 0.27073 0.21534 0.28697 0.01593  0.05454  0.04740  197 TYR A CD1 
134  C CD2 . TYR A 17  ? 0.21600 0.19342 0.23230 0.01702  0.04211  0.04928  197 TYR A CD2 
135  C CE1 . TYR A 17  ? 0.32168 0.26954 0.35364 0.00241  0.05943  0.04193  197 TYR A CE1 
136  C CE2 . TYR A 17  ? 0.25374 0.22927 0.28040 0.00627  0.04698  0.04535  197 TYR A CE2 
137  C CZ  . TYR A 17  ? 0.29859 0.26294 0.33531 -0.00064 0.05536  0.04101  197 TYR A CZ  
138  O OH  . TYR A 17  ? 0.34201 0.31269 0.39456 -0.01023 0.05911  0.03374  197 TYR A OH  
148  N N   . ILE A 18  ? 0.18035 0.21186 0.21492 0.02679  0.02474  0.04112  198 ILE A N   
149  C CA  . ILE A 18  ? 0.17475 0.21802 0.21801 0.01341  0.02219  0.03766  198 ILE A CA  
150  C C   . ILE A 18  ? 0.16829 0.21884 0.21665 0.01208  0.02320  0.03350  198 ILE A C   
151  O O   . ILE A 18  ? 0.17476 0.21680 0.22299 0.00494  0.02316  0.03067  198 ILE A O   
152  C CB  . ILE A 18  ? 0.17711 0.23932 0.22110 0.00848  0.01655  0.03742  198 ILE A CB  
153  C CG1 . ILE A 18  ? 0.21082 0.26157 0.24549 0.01039  0.01510  0.04078  198 ILE A CG1 
154  C CG2 . ILE A 18  ? 0.16848 0.23428 0.21399 -0.00604 0.01525  0.03455  198 ILE A CG2 
155  C CD1 . ILE A 18  ? 0.20799 0.27693 0.24175 0.00911  0.00742  0.03896  198 ILE A CD1 
167  N N   . VAL A 19  ? 0.15899 0.22622 0.20999 0.02085  0.02348  0.03204  199 VAL A N   
168  C CA  . VAL A 19  ? 0.16608 0.24183 0.21960 0.02068  0.02625  0.02781  199 VAL A CA  
169  C C   . VAL A 19  ? 0.17796 0.22852 0.22633 0.02341  0.02792  0.02571  199 VAL A C   
170  O O   . VAL A 19  ? 0.18619 0.23163 0.23167 0.01694  0.02777  0.02255  199 VAL A O   
171  C CB  . VAL A 19  ? 0.15783 0.26074 0.21750 0.03279  0.02670  0.02469  199 VAL A CB  
172  C CG1 . VAL A 19  ? 0.18081 0.28721 0.23950 0.03706  0.03141  0.02021  199 VAL A CG1 
173  C CG2 . VAL A 19  ? 0.15804 0.29522 0.22944 0.02495  0.02507  0.02224  199 VAL A CG2 
183  N N   . PRO A 20  ? 0.18040 0.21185 0.22469 0.03268  0.02922  0.02635  200 PRO A N   
184  C CA  . PRO A 20  ? 0.21412 0.22302 0.25648 0.03185  0.03031  0.02164  200 PRO A CA  
185  C C   . PRO A 20  ? 0.20656 0.20647 0.25477 0.01958  0.02868  0.01883  200 PRO A C   
186  O O   . PRO A 20  ? 0.22484 0.21874 0.27416 0.01738  0.02573  0.01166  200 PRO A O   
187  C CB  . PRO A 20  ? 0.24893 0.23430 0.28246 0.04173  0.03365  0.02374  200 PRO A CB  
188  C CG  . PRO A 20  ? 0.30426 0.29456 0.33276 0.04615  0.03378  0.03106  200 PRO A CG  
189  C CD  . PRO A 20  ? 0.20407 0.23054 0.24146 0.04507  0.02941  0.03047  200 PRO A CD  
197  N N   A CYS A 21  ? 0.20457 0.20535 0.25573 0.01355  0.02932  0.02288  201 CYS A N   
198  N N   B CYS A 21  ? 0.20405 0.20507 0.25531 0.01338  0.02916  0.02268  201 CYS A N   
199  C CA  A CYS A 21  ? 0.20360 0.20107 0.26191 0.00461  0.02716  0.01833  201 CYS A CA  
200  C CA  B CYS A 21  ? 0.20297 0.19996 0.26153 0.00462  0.02706  0.01784  201 CYS A CA  
201  C C   A CYS A 21  ? 0.19429 0.19895 0.24841 0.00249  0.02044  0.01455  201 CYS A C   
202  C C   B CYS A 21  ? 0.19503 0.19975 0.24928 0.00213  0.02026  0.01453  201 CYS A C   
203  O O   A CYS A 21  ? 0.20890 0.20761 0.26498 0.00194  0.01559  0.00632  201 CYS A O   
204  O O   B CYS A 21  ? 0.20192 0.20115 0.25828 0.00115  0.01516  0.00646  201 CYS A O   
205  C CB  A CYS A 21  ? 0.22090 0.22072 0.27953 0.00070  0.02900  0.02333  201 CYS A CB  
206  C CB  B CYS A 21  ? 0.22060 0.21737 0.28001 0.00104  0.03027  0.02289  201 CYS A CB  
207  S SG  A CYS A 21  ? 0.22582 0.20808 0.28643 -0.00149 0.03943  0.02525  201 CYS A SG  
208  S SG  B CYS A 21  ? 0.21175 0.20518 0.28435 -0.00703 0.03187  0.01545  201 CYS A SG  
218  N N   . MET A 22  ? 0.18378 0.19972 0.23016 0.00114  0.02000  0.01963  202 MET A N   
219  C CA  . MET A 22  ? 0.18586 0.20016 0.22032 -0.00289 0.01633  0.01800  202 MET A CA  
220  C C   . MET A 22  ? 0.19125 0.19978 0.21776 0.00218  0.01605  0.01312  202 MET A C   
221  O O   . MET A 22  ? 0.20153 0.19717 0.21573 0.00322  0.01052  0.00825  202 MET A O   
222  C CB  . MET A 22  ? 0.18737 0.21523 0.21699 -0.00919 0.01921  0.02363  202 MET A CB  
223  C CG  . MET A 22  ? 0.19030 0.21801 0.22087 -0.01448 0.01630  0.02658  202 MET A CG  
224  S SD  . MET A 22  ? 0.21255 0.21856 0.22991 -0.01691 0.00897  0.02309  202 MET A SD  
225  C CE  . MET A 22  ? 0.24283 0.23832 0.23613 -0.02549 0.00995  0.02504  202 MET A CE  
235  N N   . ASN A 23  ? 0.18668 0.20311 0.21637 0.00801  0.02100  0.01362  203 ASN A N   
236  C CA  . ASN A 23  ? 0.21407 0.22493 0.23266 0.01393  0.02140  0.00873  203 ASN A CA  
237  C C   . ASN A 23  ? 0.23881 0.23225 0.25904 0.01858  0.01440  -0.00046 203 ASN A C   
238  O O   . ASN A 23  ? 0.26621 0.24915 0.27180 0.02266  0.00961  -0.00650 203 ASN A O   
239  C CB  . ASN A 23  ? 0.20594 0.23167 0.22760 0.02149  0.02809  0.00988  203 ASN A CB  
240  C CG  . ASN A 23  ? 0.23055 0.28100 0.25286 0.01579  0.03490  0.01428  203 ASN A CG  
241  O OD1 . ASN A 23  ? 0.23820 0.28692 0.24929 0.00551  0.03724  0.01605  203 ASN A OD1 
242  N ND2 . ASN A 23  ? 0.23891 0.31139 0.27348 0.02261  0.03789  0.01490  203 ASN A ND2 
249  N N   . LYS A 24  ? 0.20043 0.18983 0.23688 0.01709  0.01381  -0.00266 204 LYS A N   
250  C CA  . LYS A 24  ? 0.20417 0.18180 0.24842 0.01773  0.00791  -0.01438 204 LYS A CA  
251  C C   . LYS A 24  ? 0.19655 0.17545 0.24505 0.01462  -0.00071 -0.02140 204 LYS A C   
252  O O   . LYS A 24  ? 0.26238 0.23615 0.31036 0.01899  -0.01010 -0.03391 204 LYS A O   
253  C CB  . LYS A 24  ? 0.21065 0.18105 0.26972 0.01389  0.01375  -0.01483 204 LYS A CB  
254  C CG  . LYS A 24  ? 0.23060 0.19120 0.28175 0.02116  0.01920  -0.01161 204 LYS A CG  
255  C CD  . LYS A 24  ? 0.26183 0.20401 0.32012 0.01586  0.02573  -0.01191 204 LYS A CD  
256  C CE  . LYS A 24  ? 0.30472 0.22702 0.34913 0.02581  0.02894  -0.01128 204 LYS A CE  
257  N NZ  . LYS A 24  ? 0.30853 0.22395 0.34773 0.03175  0.02238  -0.02265 204 LYS A NZ  
271  N N   . HIS A 25  ? 0.19388 0.17977 0.24625 0.00929  0.00072  -0.01549 205 HIS A N   
272  C CA  . HIS A 25  ? 0.18406 0.17292 0.24380 0.00866  -0.00716 -0.02370 205 HIS A CA  
273  C C   . HIS A 25  ? 0.19546 0.17995 0.23459 0.01075  -0.01220 -0.01889 205 HIS A C   
274  O O   . HIS A 25  ? 0.20759 0.19022 0.24483 0.01581  -0.02205 -0.02755 205 HIS A O   
275  C CB  . HIS A 25  ? 0.18959 0.18702 0.27173 0.00095  -0.00012 -0.02336 205 HIS A CB  
276  C CG  . HIS A 25  ? 0.18453 0.17785 0.28164 -0.00420 0.00817  -0.02597 205 HIS A CG  
277  N ND1 . HIS A 25  ? 0.20961 0.20073 0.31883 -0.00486 0.00372  -0.04026 205 HIS A ND1 
278  C CD2 . HIS A 25  ? 0.19267 0.17845 0.28957 -0.00809 0.01992  -0.01654 205 HIS A CD2 
279  C CE1 . HIS A 25  ? 0.24679 0.22690 0.36310 -0.01157 0.01403  -0.03903 205 HIS A CE1 
280  N NE2 . HIS A 25  ? 0.21964 0.19436 0.32610 -0.01238 0.02402  -0.02400 205 HIS A NE2 
288  N N   . GLY A 26  ? 0.20362 0.18638 0.22769 0.00697  -0.00584 -0.00671 206 GLY A N   
289  C CA  . GLY A 26  ? 0.21556 0.18856 0.21752 0.00509  -0.00844 -0.00166 206 GLY A CA  
290  C C   . GLY A 26  ? 0.20139 0.17747 0.20982 0.00201  -0.00992 -0.00021 206 GLY A C   
291  O O   . GLY A 26  ? 0.19794 0.16035 0.18529 0.00121  -0.01379 0.00237  206 GLY A O   
295  N N   . ILE A 27  ? 0.19266 0.18244 0.22575 0.00006  -0.00559 -0.00140 207 ILE A N   
296  C CA  . ILE A 27  ? 0.17518 0.16987 0.21576 -0.00174 -0.00477 -0.00079 207 ILE A CA  
297  C C   . ILE A 27  ? 0.19677 0.20056 0.25182 -0.00632 0.00599  0.00560  207 ILE A C   
298  O O   . ILE A 27  ? 0.20519 0.21058 0.27224 -0.00667 0.01114  0.00373  207 ILE A O   
299  C CB  . ILE A 27  ? 0.19104 0.19139 0.24593 0.00401  -0.01103 -0.01435 207 ILE A CB  
300  C CG1 . ILE A 27  ? 0.17236 0.15992 0.20748 0.01409  -0.02489 -0.02231 207 ILE A CG1 
301  C CG2 . ILE A 27  ? 0.20704 0.21454 0.26910 0.00304  -0.00778 -0.01405 207 ILE A CG2 
302  C CD1 . ILE A 27  ? 0.26313 0.26290 0.31582 0.02353  -0.03457 -0.04007 207 ILE A CD1 
314  N N   . CYS A 28  ? 0.18036 0.18570 0.23045 -0.00862 0.00868  0.01236  208 CYS A N   
315  C CA  . CYS A 28  ? 0.16685 0.17546 0.22227 -0.00953 0.01770  0.01900  208 CYS A CA  
316  C C   . CYS A 28  ? 0.13820 0.14674 0.18929 -0.00955 0.01900  0.02106  208 CYS A C   
317  O O   . CYS A 28  ? 0.18023 0.18718 0.21880 -0.01011 0.01277  0.02278  208 CYS A O   
318  C CB  . CYS A 28  ? 0.16541 0.17828 0.21330 -0.00873 0.01846  0.02642  208 CYS A CB  
319  S SG  . CYS A 28  ? 0.20081 0.21244 0.24610 -0.00353 0.02562  0.03387  208 CYS A SG  
325  N N   . VAL A 29  ? 0.16442 0.17199 0.22330 -0.00981 0.02842  0.02082  209 VAL A N   
326  C CA  . VAL A 29  ? 0.16840 0.17494 0.22077 -0.00848 0.03236  0.02276  209 VAL A CA  
327  C C   . VAL A 29  ? 0.21045 0.20816 0.25045 -0.00597 0.04062  0.03255  209 VAL A C   
328  O O   . VAL A 29  ? 0.21465 0.20345 0.25680 -0.00692 0.05007  0.03507  209 VAL A O   
329  C CB  . VAL A 29  ? 0.17994 0.19298 0.24895 -0.01054 0.03942  0.01345  209 VAL A CB  
330  C CG1 . VAL A 29  ? 0.24174 0.25372 0.30299 -0.00870 0.04748  0.01553  209 VAL A CG1 
331  C CG2 . VAL A 29  ? 0.22684 0.24858 0.30380 -0.00732 0.02720  0.00179  209 VAL A CG2 
341  N N   . VAL A 30  ? 0.18499 0.18161 0.20874 -0.00175 0.03611  0.03710  210 VAL A N   
342  C CA  . VAL A 30  ? 0.20040 0.18708 0.20589 0.00507  0.04079  0.04520  210 VAL A CA  
343  C C   . VAL A 30  ? 0.23324 0.21420 0.22711 0.00729  0.04584  0.04510  210 VAL A C   
344  O O   . VAL A 30  ? 0.23382 0.21947 0.22108 0.00880  0.03630  0.04227  210 VAL A O   
345  C CB  . VAL A 30  ? 0.23054 0.22548 0.22731 0.01005  0.02875  0.04768  210 VAL A CB  
346  C CG1 . VAL A 30  ? 0.27885 0.26294 0.25356 0.02167  0.03061  0.05401  210 VAL A CG1 
347  C CG2 . VAL A 30  ? 0.24353 0.24853 0.25255 0.00851  0.02518  0.04658  210 VAL A CG2 
357  N N   . ASP A 31  ? 0.25483 0.22330 0.24359 0.00696  0.06181  0.04788  211 ASP A N   
358  C CA  . ASP A 31  ? 0.22819 0.19168 0.20397 0.00971  0.06987  0.04773  211 ASP A CA  
359  C C   . ASP A 31  ? 0.28737 0.23370 0.22920 0.02120  0.06877  0.05648  211 ASP A C   
360  O O   . ASP A 31  ? 0.31234 0.24772 0.24091 0.02750  0.06635  0.06298  211 ASP A O   
361  C CB  . ASP A 31  ? 0.29738 0.25828 0.28480 0.00145  0.09071  0.04483  211 ASP A CB  
362  C CG  . ASP A 31  ? 0.27640 0.26198 0.29562 -0.00478 0.08809  0.03120  211 ASP A CG  
363  O OD1 . ASP A 31  ? 0.32350 0.31929 0.34160 0.00115  0.07483  0.02582  211 ASP A OD1 
364  O OD2 . ASP A 31  ? 0.36935 0.36243 0.41275 -0.01466 0.09846  0.02469  211 ASP A OD2 
369  N N   . ASP A 32  ? 0.30797 0.25161 0.23353 0.02655  0.06937  0.05531  212 ASP A N   
370  C CA  . ASP A 32  ? 0.32940 0.25552 0.21837 0.03987  0.06695  0.06181  212 ASP A CA  
371  C C   . ASP A 32  ? 0.29762 0.23087 0.18255 0.04675  0.04655  0.06219  212 ASP A C   
372  O O   . ASP A 32  ? 0.34386 0.26418 0.20778 0.05799  0.04484  0.06821  212 ASP A O   
373  C CB  . ASP A 32  ? 0.38480 0.28199 0.24808 0.04337  0.08805  0.07133  212 ASP A CB  
374  C CG  . ASP A 32  ? 0.41398 0.31060 0.28640 0.03306  0.11106  0.06864  212 ASP A CG  
375  O OD1 . ASP A 32  ? 0.42975 0.33539 0.29934 0.03594  0.11117  0.06321  212 ASP A OD1 
376  O OD2 . ASP A 32  ? 0.46988 0.36056 0.35624 0.02144  0.12739  0.06924  212 ASP A OD2 
381  N N   . PHE A 33  ? 0.28843 0.24233 0.19294 0.04014  0.03131  0.05460  213 PHE A N   
382  C CA  . PHE A 33  ? 0.26474 0.23390 0.17595 0.04095  0.01463  0.05222  213 PHE A CA  
383  C C   . PHE A 33  ? 0.32818 0.29615 0.21543 0.05355  0.00189  0.05089  213 PHE A C   
384  O O   . PHE A 33  ? 0.33118 0.30568 0.21419 0.06304  -0.00593 0.05150  213 PHE A O   
385  C CB  . PHE A 33  ? 0.25206 0.23716 0.18560 0.02744  0.00560  0.04486  213 PHE A CB  
386  C CG  . PHE A 33  ? 0.26868 0.27275 0.21229 0.02316  -0.00830 0.04070  213 PHE A CG  
387  C CD1 . PHE A 33  ? 0.27331 0.28884 0.22376 0.02871  -0.00920 0.04281  213 PHE A CD1 
388  C CD2 . PHE A 33  ? 0.26212 0.27193 0.20799 0.01327  -0.01912 0.03377  213 PHE A CD2 
389  C CE1 . PHE A 33  ? 0.25154 0.29218 0.21681 0.02375  -0.02005 0.03665  213 PHE A CE1 
390  C CE2 . PHE A 33  ? 0.24535 0.27544 0.20385 0.00493  -0.02871 0.02847  213 PHE A CE2 
391  C CZ  . PHE A 33  ? 0.24982 0.29936 0.22068 0.01035  -0.02870 0.02939  213 PHE A CZ  
401  N N   . LEU A 34  ? 0.30690 0.26856 0.17853 0.05551  -0.00270 0.04691  214 LEU A N   
402  C CA  . LEU A 34  ? 0.35378 0.31625 0.20377 0.06682  -0.01844 0.04242  214 LEU A CA  
403  C C   . LEU A 34  ? 0.38347 0.31988 0.19372 0.08378  -0.01149 0.04750  214 LEU A C   
404  O O   . LEU A 34  ? 0.42470 0.35871 0.21144 0.09757  -0.02532 0.04388  214 LEU A O   
405  C CB  . LEU A 34  ? 0.29718 0.26915 0.15399 0.05647  -0.03305 0.03177  214 LEU A CB  
406  C CG  . LEU A 34  ? 0.31641 0.30984 0.20527 0.03853  -0.03954 0.02667  214 LEU A CG  
407  C CD1 . LEU A 34  ? 0.31905 0.31126 0.20805 0.02584  -0.05096 0.01729  214 LEU A CD1 
408  C CD2 . LEU A 34  ? 0.36919 0.38699 0.27113 0.04186  -0.04813 0.02423  214 LEU A CD2 
420  N N   . GLY A 35  ? 0.37911 0.29733 0.18140 0.08270  0.00970  0.05443  215 GLY A N   
421  C CA  . GLY A 35  ? 0.39622 0.28772 0.15887 0.09610  0.02117  0.05965  215 GLY A CA  
422  C C   . GLY A 35  ? 0.41717 0.30676 0.17040 0.09629  0.02049  0.05296  215 GLY A C   
423  O O   . GLY A 35  ? 0.40211 0.30673 0.17294 0.08850  0.00623  0.04347  215 GLY A O   
427  N N   . LYS A 36  ? 0.54419 0.28521 0.17135 0.08690  0.00499  0.03126  216 LYS A N   
428  C CA  . LYS A 36  ? 0.52235 0.29159 0.17215 0.07252  0.01739  0.03729  216 LYS A CA  
429  C C   . LYS A 36  ? 0.48010 0.28157 0.14340 0.08013  0.02575  0.02447  216 LYS A C   
430  O O   . LYS A 36  ? 0.49175 0.31567 0.17689 0.07368  0.03706  0.02105  216 LYS A O   
431  C CB  . LYS A 36  ? 0.59311 0.35043 0.23230 0.06308  0.01711  0.05526  216 LYS A CB  
432  C CG  . LYS A 36  ? 0.65568 0.43377 0.31598 0.05149  0.03703  0.07087  216 LYS A CG  
433  C CD  . LYS A 36  ? 0.61187 0.38397 0.27177 0.04286  0.03921  0.09334  216 LYS A CD  
440  N N   A GLU A 37  ? 0.50300 0.30239 0.15229 0.09207  0.01625  0.01968  217 GLU A N   
441  N N   B GLU A 37  ? 0.50289 0.30228 0.15219 0.09207  0.01625  0.01968  217 GLU A N   
442  C CA  A GLU A 37  ? 0.48163 0.30048 0.13650 0.09404  0.01491  0.01170  217 GLU A CA  
443  C CA  B GLU A 37  ? 0.48156 0.30039 0.13642 0.09405  0.01490  0.01170  217 GLU A CA  
444  C C   A GLU A 37  ? 0.48648 0.33607 0.17780 0.09529  0.01740  0.00282  217 GLU A C   
445  C C   B GLU A 37  ? 0.48650 0.33608 0.17781 0.09529  0.01739  0.00282  217 GLU A C   
446  O O   A GLU A 37  ? 0.48173 0.34534 0.18261 0.08771  0.02332  -0.00229 217 GLU A O   
447  O O   B GLU A 37  ? 0.48163 0.34522 0.18247 0.08772  0.02331  -0.00229 217 GLU A O   
448  C CB  A GLU A 37  ? 0.54323 0.35230 0.18196 0.10332  -0.00414 0.01336  217 GLU A CB  
449  C CB  B GLU A 37  ? 0.54324 0.35228 0.18195 0.10333  -0.00415 0.01337  217 GLU A CB  
450  C CG  A GLU A 37  ? 0.61611 0.43544 0.25597 0.10077  -0.01612 0.00892  217 GLU A CG  
451  C CG  B GLU A 37  ? 0.61627 0.43551 0.25603 0.10078  -0.01613 0.00894  217 GLU A CG  
460  N N   . THR A 38  ? 0.44565 0.30184 0.15382 0.10660  0.01511  0.00211  218 THR A N   
461  C CA  . THR A 38  ? 0.40758 0.29387 0.15028 0.10886  0.02069  -0.00277 218 THR A CA  
462  C C   . THR A 38  ? 0.42177 0.30899 0.17009 0.09505  0.03263  -0.00655 218 THR A C   
463  O O   . THR A 38  ? 0.38588 0.29836 0.15839 0.08841  0.03581  -0.01119 218 THR A O   
464  C CB  . THR A 38  ? 0.41835 0.30432 0.17021 0.12917  0.02398  0.00044  218 THR A CB  
465  O OG1 . THR A 38  ? 0.47001 0.36374 0.23115 0.14254  0.01144  0.00853  218 THR A OG1 
466  C CG2 . THR A 38  ? 0.41307 0.32941 0.19885 0.13302  0.03528  -0.00101 218 THR A CG2 
474  N N   . GLY A 39  ? 0.41249 0.27105 0.14128 0.08853  0.03528  -0.00180 219 GLY A N   
475  C CA  . GLY A 39  ? 0.44505 0.30451 0.18577 0.07240  0.04142  0.00022  219 GLY A CA  
476  C C   . GLY A 39  ? 0.42063 0.30171 0.17937 0.06237  0.04954  0.00105  219 GLY A C   
477  O O   . GLY A 39  ? 0.40322 0.30134 0.18555 0.05427  0.05500  -0.00168 219 GLY A O   
481  N N   . GLN A 40  ? 0.41054 0.28479 0.15223 0.06445  0.05214  0.00532  220 GLN A N   
482  C CA  . GLN A 40  ? 0.40075 0.28231 0.14438 0.06134  0.06525  0.00552  220 GLN A CA  
483  C C   . GLN A 40  ? 0.40717 0.30258 0.15598 0.06380  0.05852  -0.00863 220 GLN A C   
484  O O   . GLN A 40  ? 0.39005 0.29208 0.15037 0.05904  0.06626  -0.01165 220 GLN A O   
485  C CB  . GLN A 40  ? 0.44542 0.30777 0.16320 0.06407  0.07095  0.01501  220 GLN A CB  
486  C CG  . GLN A 40  ? 0.52372 0.37669 0.24502 0.05731  0.07805  0.03665  220 GLN A CG  
487  C CD  . GLN A 40  ? 0.69786 0.54572 0.41438 0.05791  0.09704  0.05369  220 GLN A CD  
488  O OE1 . GLN A 40  ? 0.63125 0.46227 0.32073 0.06190  0.09310  0.05575  220 GLN A OE1 
489  N NE2 . GLN A 40  ? 0.70011 0.56490 0.44949 0.05487  0.11748  0.06650  220 GLN A NE2 
498  N N   . GLN A 41  ? 0.41427 0.31391 0.15853 0.07089  0.04230  -0.01390 221 GLN A N   
499  C CA  . GLN A 41  ? 0.40045 0.31522 0.15622 0.06921  0.02994  -0.02083 221 GLN A CA  
500  C C   . GLN A 41  ? 0.35474 0.29724 0.14941 0.06329  0.03500  -0.02399 221 GLN A C   
501  O O   . GLN A 41  ? 0.37102 0.32029 0.17352 0.05621  0.03193  -0.02889 221 GLN A O   
502  C CB  . GLN A 41  ? 0.43740 0.35978 0.19861 0.07650  0.00927  -0.01674 221 GLN A CB  
503  C CG  . GLN A 41  ? 0.44389 0.33414 0.16187 0.07904  -0.00334 -0.01348 221 GLN A CG  
504  C CD  . GLN A 41  ? 0.57016 0.47016 0.30327 0.08727  -0.02459 -0.00408 221 GLN A CD  
505  O OE1 . GLN A 41  ? 0.58559 0.51683 0.36215 0.09633  -0.02300 0.00156  221 GLN A OE1 
506  N NE2 . GLN A 41  ? 0.70296 0.57242 0.39753 0.08599  -0.04242 -0.00017 221 GLN A NE2 
515  N N   . ILE A 42  ? 0.33859 0.28826 0.14895 0.06571  0.04151  -0.02117 222 ILE A N   
516  C CA  . ILE A 42  ? 0.30149 0.26777 0.13796 0.05891  0.04741  -0.02317 222 ILE A CA  
517  C C   . ILE A 42  ? 0.30752 0.26934 0.14840 0.04638  0.05552  -0.02349 222 ILE A C   
518  O O   . ILE A 42  ? 0.31752 0.29443 0.17835 0.03896  0.05536  -0.02738 222 ILE A O   
519  C CB  . ILE A 42  ? 0.32495 0.27811 0.15454 0.06491  0.05249  -0.02002 222 ILE A CB  
520  C CG1 . ILE A 42  ? 0.32255 0.28589 0.15669 0.08349  0.05094  -0.01734 222 ILE A CG1 
521  C CG2 . ILE A 42  ? 0.31933 0.27571 0.16170 0.05466  0.05775  -0.02121 222 ILE A CG2 
522  C CD1 . ILE A 42  ? 0.34352 0.27635 0.15117 0.09774  0.05846  -0.01497 222 ILE A CD1 
534  N N   . GLY A 43  ? 0.36696 0.31005 0.19461 0.04447  0.06322  -0.01579 223 GLY A N   
535  C CA  . GLY A 43  ? 0.35010 0.29407 0.19253 0.03652  0.07535  -0.00925 223 GLY A CA  
536  C C   . GLY A 43  ? 0.34057 0.28466 0.17575 0.04026  0.08030  -0.01747 223 GLY A C   
537  O O   . GLY A 43  ? 0.34906 0.30028 0.20460 0.03519  0.08709  -0.01724 223 GLY A O   
541  N N   . ASP A 44  ? 0.35734 0.28590 0.15961 0.04805  0.07378  -0.02347 224 ASP A N   
542  C CA  . ASP A 44  ? 0.39237 0.30423 0.17386 0.04945  0.07128  -0.03129 224 ASP A CA  
543  C C   . ASP A 44  ? 0.37670 0.30307 0.17324 0.04256  0.05663  -0.04034 224 ASP A C   
544  O O   . ASP A 44  ? 0.37472 0.29059 0.16767 0.04019  0.05928  -0.04521 224 ASP A O   
545  C CB  . ASP A 44  ? 0.42542 0.30879 0.16236 0.05484  0.05889  -0.03366 224 ASP A CB  
546  C CG  . ASP A 44  ? 0.54591 0.41115 0.26753 0.06057  0.07425  -0.02371 224 ASP A CG  
547  O OD1 . ASP A 44  ? 0.49932 0.37324 0.24421 0.06178  0.09544  -0.01312 224 ASP A OD1 
548  O OD2 . ASP A 44  ? 0.64154 0.48250 0.32667 0.06399  0.06416  -0.02401 224 ASP A OD2 
553  N N   . GLU A 45  ? 0.34794 0.30117 0.16975 0.03912  0.04079  -0.03933 225 GLU A N   
554  C CA  . GLU A 45  ? 0.30116 0.27959 0.15409 0.03013  0.02649  -0.04101 225 GLU A CA  
555  C C   . GLU A 45  ? 0.31579 0.30839 0.19765 0.02212  0.03829  -0.04147 225 GLU A C   
556  O O   . GLU A 45  ? 0.30622 0.30307 0.19938 0.01365  0.03065  -0.04485 225 GLU A O   
557  C CB  . GLU A 45  ? 0.27765 0.28579 0.15765 0.03365  0.01672  -0.03365 225 GLU A CB  
558  C CG  . GLU A 45  ? 0.32772 0.32589 0.18982 0.03863  -0.00185 -0.02923 225 GLU A CG  
559  C CD  . GLU A 45  ? 0.28966 0.32271 0.19025 0.04561  -0.00970 -0.01626 225 GLU A CD  
560  O OE1 . GLU A 45  ? 0.28207 0.34224 0.21454 0.04990  0.00457  -0.01218 225 GLU A OE1 
561  O OE2 . GLU A 45  ? 0.37033 0.40038 0.26747 0.04799  -0.02976 -0.00781 225 GLU A OE2 
568  N N   . VAL A 46  ? 0.27918 0.27354 0.17053 0.02238  0.05251  -0.03625 226 VAL A N   
569  C CA  . VAL A 46  ? 0.25860 0.26099 0.17618 0.01173  0.05850  -0.03306 226 VAL A CA  
570  C C   . VAL A 46  ? 0.26427 0.25467 0.18305 0.01120  0.06824  -0.03241 226 VAL A C   
571  O O   . VAL A 46  ? 0.27341 0.27075 0.21266 0.00309  0.06601  -0.03380 226 VAL A O   
572  C CB  . VAL A 46  ? 0.25195 0.24720 0.17156 0.00866  0.06305  -0.02398 226 VAL A CB  
573  C CG1 . VAL A 46  ? 0.23317 0.22843 0.17796 -0.00602 0.06405  -0.01571 226 VAL A CG1 
574  C CG2 . VAL A 46  ? 0.28548 0.28353 0.19621 0.01379  0.05822  -0.02597 226 VAL A CG2 
584  N N   . ARG A 47  ? 0.28990 0.26000 0.18545 0.02203  0.08181  -0.02869 227 ARG A N   
585  C CA  . ARG A 47  ? 0.27508 0.22971 0.16853 0.02879  0.09990  -0.02495 227 ARG A CA  
586  C C   . ARG A 47  ? 0.33202 0.26585 0.19818 0.03116  0.09076  -0.03939 227 ARG A C   
587  O O   . ARG A 47  ? 0.34037 0.26333 0.21238 0.03408  0.10074  -0.03910 227 ARG A O   
588  C CB  . ARG A 47  ? 0.33524 0.27177 0.20662 0.04206  0.11783  -0.01480 227 ARG A CB  
589  C CG  . ARG A 47  ? 0.36776 0.32160 0.27768 0.03779  0.13165  0.00843  227 ARG A CG  
590  C CD  . ARG A 47  ? 0.44596 0.38837 0.34561 0.04834  0.14557  0.02345  227 ARG A CD  
591  N NE  . ARG A 47  ? 0.48616 0.41329 0.34396 0.05168  0.13478  0.01454  227 ARG A NE  
592  C CZ  . ARG A 47  ? 0.49304 0.42445 0.35052 0.04647  0.12966  0.02254  227 ARG A CZ  
593  N NH1 . ARG A 47  ? 0.46406 0.41041 0.35858 0.03338  0.12684  0.03917  227 ARG A NH1 
594  N NH2 . ARG A 47  ? 0.48109 0.39704 0.30198 0.05135  0.11934  0.01512  227 ARG A NH2 
608  N N   . ALA A 48  ? 0.33761 0.26333 0.17582 0.02885  0.06841  -0.04931 228 ALA A N   
609  C CA  . ALA A 48  ? 0.36727 0.26751 0.17833 0.02521  0.04970  -0.05947 228 ALA A CA  
610  C C   . ALA A 48  ? 0.31207 0.24253 0.16777 0.00940  0.03514  -0.05973 228 ALA A C   
611  O O   . ALA A 48  ? 0.35688 0.26406 0.19967 0.00668  0.02843  -0.06522 228 ALA A O   
612  C CB  . ALA A 48  ? 0.44040 0.32060 0.21241 0.02359  0.02340  -0.06318 228 ALA A CB  
618  N N   . LEU A 49  ? 0.28398 0.25857 0.18440 0.00023  0.03125  -0.05355 229 LEU A N   
619  C CA  . LEU A 49  ? 0.25190 0.25230 0.19114 -0.01411 0.02317  -0.05161 229 LEU A CA  
620  C C   . LEU A 49  ? 0.24192 0.23358 0.19541 -0.01492 0.03818  -0.04997 229 LEU A C   
621  O O   . LEU A 49  ? 0.26453 0.25329 0.22881 -0.02331 0.02933  -0.05231 229 LEU A O   
622  C CB  . LEU A 49  ? 0.24841 0.28373 0.21762 -0.01859 0.02516  -0.04443 229 LEU A CB  
623  C CG  . LEU A 49  ? 0.22438 0.27889 0.19668 -0.01542 0.01328  -0.04035 229 LEU A CG  
624  C CD1 . LEU A 49  ? 0.20714 0.28063 0.19278 -0.01030 0.02554  -0.03388 229 LEU A CD1 
625  C CD2 . LEU A 49  ? 0.24335 0.31594 0.23682 -0.02754 -0.00940 -0.03557 229 LEU A CD2 
637  N N   . HIS A 50  ? 0.27698 0.26562 0.23591 -0.00696 0.05908  -0.04217 230 HIS A N   
638  C CA  . HIS A 50  ? 0.24433 0.23088 0.23044 -0.00658 0.07404  -0.03252 230 HIS A CA  
639  C C   . HIS A 50  ? 0.28089 0.23334 0.24073 0.00718  0.08376  -0.03853 230 HIS A C   
640  O O   . HIS A 50  ? 0.27596 0.22537 0.25450 0.00313  0.08155  -0.03809 230 HIS A O   
641  C CB  . HIS A 50  ? 0.24102 0.23240 0.24085 -0.00118 0.09155  -0.01640 230 HIS A CB  
642  C CG  . HIS A 50  ? 0.22916 0.23140 0.27779 -0.00630 0.10146  0.00407  230 HIS A CG  
643  N ND1 . HIS A 50  ? 0.23741 0.24721 0.31149 -0.00602 0.11262  0.02697  230 HIS A ND1 
644  C CD2 . HIS A 50  ? 0.21067 0.21894 0.29360 -0.01396 0.09818  0.00944  230 HIS A CD2 
645  C CE1 . HIS A 50  ? 0.25974 0.28241 0.38682 -0.01383 0.11482  0.04822  230 HIS A CE1 
646  N NE2 . HIS A 50  ? 0.19179 0.21314 0.32396 -0.01792 0.10683  0.03687  230 HIS A NE2 
654  N N   . ASP A 51  ? 0.32788 0.24572 0.23497 0.02408  0.09313  -0.04492 231 ASP A N   
655  C CA  . ASP A 51  ? 0.39613 0.26276 0.25691 0.04251  0.10742  -0.05090 231 ASP A CA  
656  C C   . ASP A 51  ? 0.39723 0.23552 0.22925 0.03310  0.07884  -0.06573 231 ASP A C   
657  O O   . ASP A 51  ? 0.49370 0.28711 0.29535 0.04606  0.08865  -0.07007 231 ASP A O   
658  C CB  . ASP A 51  ? 0.42860 0.25895 0.23002 0.05969  0.11905  -0.05247 231 ASP A CB  
659  C CG  . ASP A 51  ? 0.70611 0.48179 0.45562 0.07548  0.12522  -0.05450 231 ASP A CG  
660  O OD1 . ASP A 51  ? 1.03764 0.81183 0.80605 0.09083  0.15435  -0.03983 231 ASP A OD1 
661  O OD2 . ASP A 51  ? 0.83577 0.56778 0.52578 0.07212  0.10045  -0.06700 231 ASP A OD2 
666  N N   . THR A 52  ? 0.42920 0.33361 0.22597 0.11168  0.02309  -0.07265 232 THR A N   
667  C CA  . THR A 52  ? 0.39463 0.27807 0.19090 0.10680  0.00209  -0.09115 232 THR A CA  
668  C C   . THR A 52  ? 0.47643 0.35561 0.30200 0.09210  0.00072  -0.09199 232 THR A C   
669  O O   . THR A 52  ? 0.48903 0.35289 0.32541 0.08226  -0.01593 -0.10375 232 THR A O   
670  C CB  . THR A 52  ? 0.42809 0.30985 0.22023 0.10165  -0.01686 -0.10037 232 THR A CB  
671  O OG1 . THR A 52  ? 0.45368 0.35256 0.26770 0.08744  -0.01469 -0.09211 232 THR A OG1 
672  C CG2 . THR A 52  ? 0.45345 0.33604 0.21525 0.11877  -0.01635 -0.09790 232 THR A CG2 
680  N N   . GLY A 53  ? 0.35996 0.25534 0.20564 0.08770  0.01714  -0.07655 233 GLY A N   
681  C CA  . GLY A 53  ? 0.36888 0.26024 0.24057 0.07613  0.01631  -0.07423 233 GLY A CA  
682  C C   . GLY A 53  ? 0.33420 0.23389 0.23535 0.05463  0.00945  -0.06937 233 GLY A C   
683  O O   . GLY A 53  ? 0.37763 0.26753 0.29604 0.04527  0.00552  -0.06963 233 GLY A O   
687  N N   . LYS A 54  ? 0.28526 0.20166 0.19172 0.04793  0.00913  -0.06400 234 LYS A N   
688  C CA  . LYS A 54  ? 0.30524 0.23022 0.23807 0.02982  0.00371  -0.05960 234 LYS A CA  
689  C C   . LYS A 54  ? 0.32555 0.26391 0.27896 0.02248  0.01447  -0.04564 234 LYS A C   
690  O O   . LYS A 54  ? 0.28655 0.22698 0.25908 0.01004  0.01164  -0.04191 234 LYS A O   
691  C CB  . LYS A 54  ? 0.30113 0.23895 0.23248 0.02671  -0.00118 -0.05924 234 LYS A CB  
692  C CG  . LYS A 54  ? 0.37957 0.30587 0.29006 0.03471  -0.01541 -0.07389 234 LYS A CG  
693  C CD  . LYS A 54  ? 0.42255 0.33130 0.34404 0.02737  -0.03158 -0.08747 234 LYS A CD  
694  C CE  . LYS A 54  ? 0.54245 0.44038 0.44288 0.03662  -0.04942 -0.10436 234 LYS A CE  
695  N NZ  . LYS A 54  ? 0.77652 0.65237 0.68692 0.03138  -0.06636 -0.12010 234 LYS A NZ  
709  N N   . PHE A 55  ? 0.24591 0.19392 0.19705 0.03050  0.02642  -0.03776 235 PHE A N   
710  C CA  . PHE A 55  ? 0.21188 0.17436 0.18294 0.02385  0.03279  -0.02635 235 PHE A CA  
711  C C   . PHE A 55  ? 0.22229 0.17467 0.20129 0.02343  0.03265  -0.02526 235 PHE A C   
712  O O   . PHE A 55  ? 0.29411 0.23280 0.26378 0.03254  0.03320  -0.03037 235 PHE A O   
713  C CB  . PHE A 55  ? 0.24122 0.22017 0.21474 0.03076  0.04397  -0.01809 235 PHE A CB  
714  C CG  . PHE A 55  ? 0.21033 0.19881 0.17725 0.03160  0.04692  -0.01511 235 PHE A CG  
715  C CD1 . PHE A 55  ? 0.24915 0.23754 0.21367 0.02443  0.03906  -0.01772 235 PHE A CD1 
716  C CD2 . PHE A 55  ? 0.20979 0.20800 0.17510 0.04051  0.05898  -0.00810 235 PHE A CD2 
717  C CE1 . PHE A 55  ? 0.27189 0.26795 0.22888 0.02720  0.04239  -0.01346 235 PHE A CE1 
718  C CE2 . PHE A 55  ? 0.22865 0.23329 0.18688 0.04270  0.06402  -0.00279 235 PHE A CE2 
719  C CZ  . PHE A 55  ? 0.24889 0.25132 0.20156 0.03625  0.05500  -0.00570 235 PHE A CZ  
729  N N   . THR A 56  ? 0.22396 0.18177 0.21762 0.01467  0.03213  -0.01825 236 THR A N   
730  C CA  . THR A 56  ? 0.21644 0.16567 0.21557 0.01584  0.03287  -0.01430 236 THR A CA  
731  C C   . THR A 56  ? 0.22307 0.18853 0.23262 0.01573  0.03567  -0.00555 236 THR A C   
732  O O   . THR A 56  ? 0.21098 0.19157 0.22594 0.01174  0.03611  -0.00292 236 THR A O   
733  C CB  . THR A 56  ? 0.30192 0.23560 0.30541 0.00669  0.02837  -0.01440 236 THR A CB  
734  O OG1 . THR A 56  ? 0.33699 0.28233 0.34903 -0.00303 0.02771  -0.01018 236 THR A OG1 
735  C CG2 . THR A 56  ? 0.40346 0.31857 0.40065 0.00620  0.02189  -0.02553 236 THR A CG2 
743  N N   . ASP A 57  ? 0.24460 0.20543 0.25636 0.02147  0.03612  -0.00178 237 ASP A N   
744  C CA  . ASP A 57  ? 0.23175 0.20779 0.25277 0.02378  0.03541  0.00401  237 ASP A CA  
745  C C   . ASP A 57  ? 0.21383 0.19595 0.23646 0.01553  0.03281  0.00744  237 ASP A C   
746  O O   . ASP A 57  ? 0.23776 0.20927 0.25540 0.01055  0.03284  0.00964  237 ASP A O   
747  C CB  . ASP A 57  ? 0.21969 0.18628 0.23891 0.03204  0.03375  0.00751  237 ASP A CB  
748  C CG  . ASP A 57  ? 0.36212 0.32643 0.38246 0.04350  0.03617  0.00487  237 ASP A CG  
749  O OD1 . ASP A 57  ? 0.35833 0.33020 0.38070 0.04610  0.04060  0.00097  237 ASP A OD1 
750  O OD2 . ASP A 57  ? 0.45349 0.40759 0.47091 0.05162  0.03441  0.00753  237 ASP A OD2 
755  N N   . GLY A 58  ? 0.20055 0.19941 0.23189 0.01466  0.03112  0.00831  238 GLY A N   
756  C CA  . GLY A 58  ? 0.18979 0.19275 0.22016 0.00996  0.02790  0.01049  238 GLY A CA  
757  C C   . GLY A 58  ? 0.18242 0.17712 0.20450 0.01506  0.02525  0.01467  238 GLY A C   
758  O O   . GLY A 58  ? 0.19110 0.18355 0.21307 0.02340  0.02259  0.01564  238 GLY A O   
762  N N   . GLN A 59  ? 0.18863 0.17925 0.20295 0.01175  0.02666  0.01792  239 GLN A N   
763  C CA  . GLN A 59  ? 0.19970 0.17977 0.20111 0.01785  0.02768  0.02443  239 GLN A CA  
764  C C   . GLN A 59  ? 0.18007 0.16637 0.17332 0.02220  0.02350  0.02495  239 GLN A C   
765  O O   . GLN A 59  ? 0.19595 0.19309 0.19562 0.01815  0.02022  0.02027  239 GLN A O   
766  C CB  . GLN A 59  ? 0.22338 0.19115 0.22307 0.01159  0.03601  0.02983  239 GLN A CB  
767  C CG  . GLN A 59  ? 0.24391 0.20054 0.24917 0.00881  0.03746  0.02731  239 GLN A CG  
768  C CD  . GLN A 59  ? 0.26975 0.21379 0.26778 0.01879  0.03680  0.03049  239 GLN A CD  
769  O OE1 . GLN A 59  ? 0.34468 0.27528 0.33358 0.02286  0.04088  0.03928  239 GLN A OE1 
770  N NE2 . GLN A 59  ? 0.30380 0.25235 0.30573 0.02425  0.03279  0.02473  239 GLN A NE2 
779  N N   . LEU A 60  ? 0.19725 0.17430 0.17376 0.03228  0.02337  0.03062  240 LEU A N   
780  C CA  . LEU A 60  ? 0.19031 0.16958 0.15205 0.04103  0.01778  0.02989  240 LEU A CA  
781  C C   . LEU A 60  ? 0.23233 0.20325 0.17723 0.04395  0.02887  0.03944  240 LEU A C   
782  O O   . LEU A 60  ? 0.24895 0.21013 0.19390 0.04094  0.04001  0.04862  240 LEU A O   
783  C CB  . LEU A 60  ? 0.24812 0.22491 0.20057 0.05479  0.00625  0.02758  240 LEU A CB  
784  C CG  . LEU A 60  ? 0.22866 0.21809 0.20303 0.05366  -0.00532 0.01872  240 LEU A CG  
785  C CD1 . LEU A 60  ? 0.22944 0.23210 0.22086 0.04426  -0.00934 0.01142  240 LEU A CD1 
786  C CD2 . LEU A 60  ? 0.22358 0.21179 0.21114 0.05027  0.00033  0.02073  240 LEU A CD2 
798  N N   . VAL A 61  ? 0.21582 0.18989 0.14708 0.05074  0.02619  0.03757  241 VAL A N   
799  C CA  . VAL A 61  ? 0.26330 0.23241 0.17900 0.05545  0.03912  0.04750  241 VAL A CA  
800  C C   . VAL A 61  ? 0.28248 0.23574 0.17773 0.06695  0.04716  0.06008  241 VAL A C   
801  O O   . VAL A 61  ? 0.29958 0.24652 0.19628 0.06381  0.06357  0.07318  241 VAL A O   
802  C CB  . VAL A 61  ? 0.23247 0.20584 0.13208 0.06482  0.03362  0.04162  241 VAL A CB  
803  C CG1 . VAL A 61  ? 0.27123 0.23882 0.14881 0.07538  0.04878  0.05354  241 VAL A CG1 
804  C CG2 . VAL A 61  ? 0.22767 0.21399 0.14818 0.05273  0.02972  0.03268  241 VAL A CG2 
814  N N   . SER A 62  ? 0.29000 0.23635 0.16674 0.08132  0.03548  0.05699  242 SER A N   
815  C CA  A SER A 62  ? 0.32367 0.25306 0.17597 0.09603  0.04034  0.06849  242 SER A CA  
816  C CA  B SER A 62  ? 0.32283 0.25223 0.17509 0.09606  0.04031  0.06847  242 SER A CA  
817  C C   . SER A 62  ? 0.32299 0.24982 0.18536 0.09650  0.02921  0.06370  242 SER A C   
818  O O   . SER A 62  ? 0.34818 0.28727 0.22489 0.09428  0.01345  0.05021  242 SER A O   
819  C CB  A SER A 62  ? 0.35402 0.27756 0.16854 0.11842  0.03332  0.06750  242 SER A CB  
820  C CB  B SER A 62  ? 0.35309 0.27670 0.16753 0.11851  0.03314  0.06736  242 SER A CB  
821  O OG  A SER A 62  ? 0.55927 0.47007 0.35628 0.13138  0.03389  0.07255  242 SER A OG  
822  O OG  B SER A 62  ? 0.56370 0.47504 0.36074 0.13183  0.03168  0.07124  242 SER A OG  
832  N N   . GLN A 63  ? 0.43691 0.34790 0.29481 0.09910  0.03856  0.07550  243 GLN A N   
833  C CA  . GLN A 63  ? 0.59651 0.50244 0.46351 0.10086  0.03120  0.07301  243 GLN A CA  
834  C C   . GLN A 63  ? 0.43575 0.32282 0.27074 0.12203  0.03137  0.08377  243 GLN A C   
835  O O   . GLN A 63  ? 0.46309 0.34072 0.28632 0.12307  0.04577  0.09374  243 GLN A O   
836  C CB  . GLN A 63  ? 0.48163 0.38340 0.37510 0.08277  0.04196  0.07548  243 GLN A CB  
837  C CG  . GLN A 63  ? 0.58652 0.48140 0.49295 0.08210  0.03781  0.07221  243 GLN A CG  
838  C CD  . GLN A 63  ? 0.71684 0.63061 0.64140 0.08156  0.02330  0.05725  243 GLN A CD  
839  O OE1 . GLN A 63  ? 0.39112 0.32131 0.33613 0.06899  0.02145  0.04791  243 GLN A OE1 
840  N NE2 . GLN A 63  ? 0.65985 0.57120 0.57791 0.09632  0.01402  0.05646  243 GLN A NE2 
849  N N   . LYS A 64  ? 0.52589 0.41596 0.35790 0.13373  0.01469  0.07571  244 LYS A N   
850  C CA  . LYS A 64  ? 0.54861 0.42999 0.35844 0.14954  0.01014  0.07704  244 LYS A CA  
851  C C   . LYS A 64  ? 0.44305 0.32167 0.26982 0.14977  0.00473  0.07592  244 LYS A C   
852  O O   . LYS A 64  ? 0.47222 0.34276 0.31557 0.13856  0.01567  0.08153  244 LYS A O   
853  C CB  . LYS A 64  ? 0.65640 0.54804 0.45083 0.16280  -0.00832 0.06432  244 LYS A CB  
856  N N   . SER A 65  ? 0.41934 0.30271 0.24188 0.16270  -0.01080 0.06880  245 SER A N   
857  C CA  . SER A 65  ? 0.41054 0.29291 0.25053 0.16428  -0.01472 0.06775  245 SER A CA  
858  C C   . SER A 65  ? 0.37011 0.27155 0.24547 0.15618  -0.02225 0.05766  245 SER A C   
859  O O   . SER A 65  ? 0.38290 0.28185 0.27366 0.15630  -0.02028 0.05776  245 SER A O   
860  C CB  . SER A 65  ? 0.47595 0.35914 0.30239 0.18104  -0.02831 0.06394  245 SER A CB  
861  O OG  . SER A 65  ? 0.54033 0.44606 0.37844 0.18446  -0.04872 0.04903  245 SER A OG  
867  N N   . ASP A 66  ? 0.38669 0.30688 0.27563 0.15049  -0.03018 0.04873  246 ASP A N   
868  C CA  . ASP A 66  ? 0.38375 0.32877 0.31121 0.14084  -0.03751 0.03678  246 ASP A CA  
869  C C   . ASP A 66  ? 0.37695 0.32226 0.32426 0.12251  -0.02180 0.03742  246 ASP A C   
870  O O   . ASP A 66  ? 0.39950 0.33480 0.33913 0.11081  -0.00915 0.04220  246 ASP A O   
871  C CB  . ASP A 66  ? 0.36254 0.32853 0.30327 0.13516  -0.05025 0.02539  246 ASP A CB  
872  C CG  . ASP A 66  ? 0.49264 0.45610 0.40924 0.15092  -0.06686 0.02145  246 ASP A CG  
873  O OD1 . ASP A 66  ? 0.49833 0.44794 0.38357 0.15370  -0.06132 0.02581  246 ASP A OD1 
874  O OD2 . ASP A 66  ? 0.44240 0.41834 0.37284 0.15648  -0.08234 0.01294  246 ASP A OD2 
879  N N   . SER A 67  ? 0.32237 0.28114 0.29649 0.12110  -0.02340 0.03179  247 SER A N   
880  C CA  . SER A 67  ? 0.28842 0.25228 0.28100 0.10555  -0.01188 0.02898  247 SER A CA  
881  C C   . SER A 67  ? 0.28796 0.26845 0.29275 0.09137  -0.01252 0.02353  247 SER A C   
882  O O   . SER A 67  ? 0.26367 0.26308 0.28339 0.09250  -0.02419 0.01743  247 SER A O   
883  C CB  . SER A 67  ? 0.30369 0.28208 0.32114 0.11043  -0.01324 0.02429  247 SER A CB  
884  O OG  . SER A 67  ? 0.32037 0.30508 0.35201 0.09788  -0.00266 0.02101  247 SER A OG  
890  N N   . SER A 68  ? 0.25019 0.22346 0.25149 0.07793  -0.00102 0.02507  248 SER A N   
891  C CA  . SER A 68  ? 0.20860 0.19618 0.22103 0.06549  -0.00076 0.02049  248 SER A CA  
892  C C   . SER A 68  ? 0.19506 0.20560 0.23662 0.06297  -0.00449 0.01429  248 SER A C   
893  O O   . SER A 68  ? 0.18484 0.20904 0.23879 0.05678  -0.00961 0.01048  248 SER A O   
894  C CB  . SER A 68  ? 0.24688 0.22550 0.25470 0.05280  0.01084  0.02222  248 SER A CB  
895  O OG  . SER A 68  ? 0.26513 0.23996 0.28024 0.05088  0.01723  0.02032  248 SER A OG  
901  N N   . LYS A 69  ? 0.21806 0.23247 0.27183 0.06814  -0.00088 0.01397  249 LYS A N   
902  C CA  . LYS A 69  ? 0.21847 0.25604 0.30260 0.06600  0.00032  0.01084  249 LYS A CA  
903  C C   . LYS A 69  ? 0.24261 0.30023 0.35088 0.07076  -0.01348 0.00773  249 LYS A C   
904  O O   . LYS A 69  ? 0.18655 0.26545 0.32620 0.06573  -0.01258 0.00632  249 LYS A O   
905  C CB  . LYS A 69  ? 0.25582 0.29154 0.34397 0.07329  0.00951  0.01170  249 LYS A CB  
906  C CG  . LYS A 69  ? 0.25196 0.27259 0.32403 0.06678  0.02133  0.01146  249 LYS A CG  
907  C CD  . LYS A 69  ? 0.33679 0.35474 0.41034 0.07604  0.02977  0.01030  249 LYS A CD  
908  C CE  . LYS A 69  ? 0.47292 0.48013 0.53272 0.06989  0.03901  0.00745  249 LYS A CE  
917  N N   . ASP A 70  ? 0.18245 0.23391 0.27837 0.08083  -0.02673 0.00677  250 ASP A N   
918  C CA  . ASP A 70  ? 0.18133 0.25055 0.29909 0.08518  -0.04466 0.00094  250 ASP A CA  
919  C C   . ASP A 70  ? 0.17402 0.24402 0.28996 0.07591  -0.05222 -0.00367 250 ASP A C   
920  O O   . ASP A 70  ? 0.20958 0.29294 0.34628 0.07750  -0.06922 -0.01073 250 ASP A O   
921  C CB  . ASP A 70  ? 0.20638 0.26704 0.30662 0.10285  -0.05803 0.00066  250 ASP A CB  
922  C CG  . ASP A 70  ? 0.23152 0.29864 0.34578 0.11391  -0.05597 0.00288  250 ASP A CG  
923  O OD1 . ASP A 70  ? 0.22239 0.31370 0.37583 0.11092  -0.05331 0.00121  250 ASP A OD1 
924  O OD2 . ASP A 70  ? 0.27288 0.32169 0.36092 0.12750  -0.05680 0.00710  250 ASP A OD2 
929  N N   . ILE A 71  ? 0.15651 0.21197 0.24915 0.06764  -0.04169 -0.00068 251 ILE A N   
930  C CA  . ILE A 71  ? 0.17644 0.22997 0.26329 0.06018  -0.04650 -0.00449 251 ILE A CA  
931  C C   . ILE A 71  ? 0.14768 0.20933 0.25300 0.04525  -0.03535 -0.00341 251 ILE A C   
932  O O   . ILE A 71  ? 0.15115 0.22361 0.27913 0.03851  -0.04197 -0.00763 251 ILE A O   
933  C CB  . ILE A 71  ? 0.19076 0.22264 0.23646 0.06444  -0.04279 -0.00082 251 ILE A CB  
934  C CG1 . ILE A 71  ? 0.26329 0.28665 0.28860 0.08194  -0.05465 -0.00095 251 ILE A CG1 
935  C CG2 . ILE A 71  ? 0.20322 0.23355 0.24251 0.05809  -0.04566 -0.00473 251 ILE A CG2 
936  C CD1 . ILE A 71  ? 0.30365 0.30479 0.28972 0.08932  -0.04583 0.00755  251 ILE A CD1 
948  N N   . ARG A 72  ? 0.14363 0.19860 0.23933 0.04063  -0.01924 0.00205  252 ARG A N   
949  C CA  . ARG A 72  ? 0.13654 0.19718 0.24346 0.02938  -0.00836 0.00372  252 ARG A CA  
950  C C   . ARG A 72  ? 0.14270 0.20467 0.25308 0.03105  0.00456  0.00739  252 ARG A C   
951  O O   . ARG A 72  ? 0.16536 0.21396 0.25680 0.03630  0.00859  0.00877  252 ARG A O   
952  C CB  . ARG A 72  ? 0.15655 0.20505 0.24119 0.02285  -0.00407 0.00436  252 ARG A CB  
953  C CG  . ARG A 72  ? 0.15263 0.18454 0.21076 0.02492  0.00296  0.00777  252 ARG A CG  
954  C CD  . ARG A 72  ? 0.17930 0.20380 0.22222 0.01897  0.00633  0.00870  252 ARG A CD  
955  N NE  . ARG A 72  ? 0.16059 0.19038 0.21144 0.01026  0.01261  0.00825  252 ARG A NE  
956  C CZ  . ARG A 72  ? 0.15282 0.17886 0.19475 0.00482  0.01626  0.00882  252 ARG A CZ  
957  N NH1 . ARG A 72  ? 0.16506 0.18375 0.19298 0.00612  0.01638  0.01066  252 ARG A NH1 
958  N NH2 . ARG A 72  ? 0.16379 0.19443 0.21138 -0.00079 0.02053  0.00839  252 ARG A NH2 
972  N N   . GLY A 73  ? 0.13022 0.20659 0.26395 0.02750  0.01173  0.00934  253 GLY A N   
973  C CA  . GLY A 73  ? 0.15650 0.23459 0.29122 0.03259  0.02423  0.01225  253 GLY A CA  
974  C C   . GLY A 73  ? 0.15404 0.22560 0.27458 0.02816  0.03655  0.01411  253 GLY A C   
975  O O   . GLY A 73  ? 0.19177 0.26649 0.31347 0.03384  0.04779  0.01631  253 GLY A O   
979  N N   . ASP A 74  ? 0.14634 0.20858 0.25145 0.02038  0.03439  0.01290  254 ASP A N   
980  C CA  . ASP A 74  ? 0.13442 0.19042 0.22484 0.01709  0.04281  0.01359  254 ASP A CA  
981  C C   . ASP A 74  ? 0.15930 0.19740 0.22442 0.01929  0.04332  0.00978  254 ASP A C   
982  O O   . ASP A 74  ? 0.17954 0.20774 0.23751 0.02129  0.03814  0.00823  254 ASP A O   
983  C CB  . ASP A 74  ? 0.16293 0.22007 0.25394 0.00818  0.03992  0.01431  254 ASP A CB  
984  C CG  . ASP A 74  ? 0.15553 0.20565 0.23796 0.00486  0.02961  0.01115  254 ASP A CG  
985  O OD1 . ASP A 74  ? 0.17684 0.22444 0.25820 0.00911  0.02311  0.00964  254 ASP A OD1 
986  O OD2 . ASP A 74  ? 0.16191 0.20841 0.23611 -0.00037 0.02893  0.01076  254 ASP A OD2 
991  N N   . LYS A 75  ? 0.16304 0.19589 0.21501 0.01969  0.04931  0.00848  255 LYS A N   
992  C CA  . LYS A 75  ? 0.16045 0.17588 0.19179 0.02020  0.04745  0.00288  255 LYS A CA  
993  C C   . LYS A 75  ? 0.15886 0.17302 0.18185 0.01347  0.04553  0.00146  255 LYS A C   
994  O O   . LYS A 75  ? 0.16145 0.18439 0.18646 0.01361  0.04994  0.00468  255 LYS A O   
995  C CB  . LYS A 75  ? 0.22205 0.23024 0.24305 0.03087  0.05310  -0.00041 255 LYS A CB  
996  C CG  . LYS A 75  ? 0.26488 0.28223 0.28388 0.03783  0.06317  0.00234  255 LYS A CG  
997  C CD  . LYS A 75  ? 0.27856 0.28764 0.28380 0.05219  0.06968  -0.00146 255 LYS A CD  
998  C CE  . LYS A 75  ? 0.28239 0.30027 0.30482 0.06001  0.07422  0.00200  255 LYS A CE  
999  N NZ  . LYS A 75  ? 0.29391 0.30417 0.30204 0.07647  0.08216  -0.00156 255 LYS A NZ  
1013 N N   . ILE A 76  ? 0.19247 0.19665 0.20909 0.00765  0.03938  -0.00203 256 ILE A N   
1014 C CA  . ILE A 76  ? 0.17858 0.18532 0.19342 0.00080  0.03595  -0.00269 256 ILE A CA  
1015 C C   . ILE A 76  ? 0.18686 0.18191 0.19379 -0.00190 0.03057  -0.00941 256 ILE A C   
1016 O O   . ILE A 76  ? 0.22510 0.20718 0.22934 -0.00065 0.02874  -0.01322 256 ILE A O   
1017 C CB  . ILE A 76  ? 0.18242 0.19499 0.20682 -0.00495 0.03342  0.00160  256 ILE A CB  
1018 C CG1 . ILE A 76  ? 0.22892 0.23180 0.25295 -0.00698 0.03155  0.00218  256 ILE A CG1 
1019 C CG2 . ILE A 76  ? 0.18733 0.20947 0.22234 -0.00225 0.03462  0.00560  256 ILE A CG2 
1020 C CD1 . ILE A 76  ? 0.24300 0.24138 0.26768 -0.01365 0.02953  0.00081  256 ILE A CD1 
1032 N N   . THR A 77  ? 0.19223 0.19166 0.19745 -0.00547 0.02691  -0.01127 257 THR A N   
1033 C CA  . THR A 77  ? 0.18382 0.17715 0.19125 -0.01106 0.01929  -0.01723 257 THR A CA  
1034 C C   . THR A 77  ? 0.19325 0.19857 0.20894 -0.01657 0.01737  -0.01434 257 THR A C   
1035 O O   . THR A 77  ? 0.19174 0.20597 0.20483 -0.01415 0.02038  -0.01019 257 THR A O   
1036 C CB  . THR A 77  ? 0.23406 0.21727 0.22689 -0.00501 0.01331  -0.02720 257 THR A CB  
1037 O OG1 . THR A 77  ? 0.26748 0.24352 0.26888 -0.01180 0.00328  -0.03461 257 THR A OG1 
1038 C CG2 . THR A 77  ? 0.25027 0.24074 0.22974 0.00158  0.01372  -0.02718 257 THR A CG2 
1046 N N   . TRP A 78  ? 0.20194 0.20718 0.22965 -0.02365 0.01273  -0.01628 258 TRP A N   
1047 C CA  . TRP A 78  ? 0.17131 0.18941 0.20988 -0.02794 0.01159  -0.01346 258 TRP A CA  
1048 C C   . TRP A 78  ? 0.17217 0.19307 0.21084 -0.02756 0.00146  -0.02167 258 TRP A C   
1049 O O   . TRP A 78  ? 0.21133 0.22391 0.25325 -0.02955 -0.00651 -0.02980 258 TRP A O   
1050 C CB  . TRP A 78  ? 0.18115 0.20067 0.23729 -0.03519 0.01518  -0.00814 258 TRP A CB  
1051 C CG  . TRP A 78  ? 0.15950 0.17565 0.21117 -0.03288 0.02357  -0.00014 258 TRP A CG  
1052 C CD1 . TRP A 78  ? 0.17701 0.18048 0.22657 -0.03233 0.02637  0.00181  258 TRP A CD1 
1053 C CD2 . TRP A 78  ? 0.21317 0.23686 0.26018 -0.02911 0.02799  0.00557  258 TRP A CD2 
1054 N NE1 . TRP A 78  ? 0.19301 0.19726 0.23626 -0.02779 0.03191  0.00884  258 TRP A NE1 
1055 C CE2 . TRP A 78  ? 0.19166 0.20780 0.23309 -0.02587 0.03220  0.01030  258 TRP A CE2 
1056 C CE3 . TRP A 78  ? 0.17114 0.20543 0.21711 -0.02703 0.02758  0.00637  258 TRP A CE3 
1057 C CZ2 . TRP A 78  ? 0.20485 0.22414 0.23915 -0.02045 0.03413  0.01425  258 TRP A CZ2 
1058 C CZ3 . TRP A 78  ? 0.18018 0.21586 0.22001 -0.02250 0.03035  0.01025  258 TRP A CZ3 
1059 C CH2 . TRP A 78  ? 0.19949 0.22794 0.23322 -0.01912 0.03281  0.01352  258 TRP A CH2 
1070 N N   . ILE A 79  ? 0.18177 0.21299 0.21653 -0.02411 0.00044  -0.02010 259 ILE A N   
1071 C CA  . ILE A 79  ? 0.17882 0.21362 0.20931 -0.02037 -0.01022 -0.02731 259 ILE A CA  
1072 C C   . ILE A 79  ? 0.18396 0.23439 0.23236 -0.02380 -0.01230 -0.02467 259 ILE A C   
1073 O O   . ILE A 79  ? 0.17072 0.22762 0.21896 -0.02240 -0.00482 -0.01702 259 ILE A O   
1074 C CB  . ILE A 79  ? 0.19928 0.23034 0.20405 -0.00928 -0.00816 -0.02614 259 ILE A CB  
1075 C CG1 . ILE A 79  ? 0.25556 0.27319 0.24326 -0.00363 -0.00492 -0.02886 259 ILE A CG1 
1076 C CG2 . ILE A 79  ? 0.24564 0.28088 0.24246 -0.00287 -0.01886 -0.03148 259 ILE A CG2 
1077 C CD1 . ILE A 79  ? 0.34125 0.34819 0.32376 -0.00196 -0.01618 -0.04115 259 ILE A CD1 
1089 N N   . GLU A 80  ? 0.17492 0.23134 0.23971 -0.02734 -0.02352 -0.03194 260 GLU A N   
1090 C CA  A GLU A 80  ? 0.21575 0.29042 0.30302 -0.02992 -0.02601 -0.02994 260 GLU A CA  
1091 C CA  B GLU A 80  ? 0.21770 0.29224 0.30469 -0.02988 -0.02583 -0.02983 260 GLU A CA  
1092 C C   . GLU A 80  ? 0.28968 0.37028 0.36275 -0.01973 -0.03315 -0.03216 260 GLU A C   
1093 O O   . GLU A 80  ? 0.28195 0.37610 0.36533 -0.01798 -0.03093 -0.02744 260 GLU A O   
1094 C CB  A GLU A 80  ? 0.26946 0.35036 0.38851 -0.03927 -0.03563 -0.03642 260 GLU A CB  
1095 C CB  B GLU A 80  ? 0.26770 0.34844 0.38598 -0.03903 -0.03556 -0.03639 260 GLU A CB  
1096 C CG  A GLU A 80  ? 0.34684 0.45100 0.49853 -0.04255 -0.03917 -0.03503 260 GLU A CG  
1097 C CG  B GLU A 80  ? 0.24824 0.32043 0.38226 -0.04922 -0.02791 -0.03259 260 GLU A CG  
1106 N N   . GLY A 81  ? 0.28603 0.35547 0.33332 -0.01109 -0.04083 -0.03860 261 GLY A N   
1107 C CA  . GLY A 81  ? 0.28684 0.35763 0.31399 0.00116  -0.04669 -0.03917 261 GLY A CA  
1108 C C   . GLY A 81  ? 0.29779 0.36932 0.32080 0.00753  -0.06633 -0.05201 261 GLY A C   
1109 O O   . GLY A 81  ? 0.31259 0.37892 0.30762 0.02135  -0.07173 -0.05321 261 GLY A O   
1113 N N   . LYS A 82  ? 0.31607 0.39277 0.36596 -0.00139 -0.07789 -0.06159 262 LYS A N   
1114 C CA  . LYS A 82  ? 0.34036 0.41919 0.39236 0.00383  -0.10094 -0.07648 262 LYS A CA  
1115 C C   . LYS A 82  ? 0.28608 0.34456 0.31967 0.00654  -0.11127 -0.08942 262 LYS A C   
1116 O O   . LYS A 82  ? 0.36078 0.41639 0.39339 0.01146  -0.13139 -0.10318 262 LYS A O   
1117 C CB  . LYS A 82  ? 0.44485 0.54520 0.54707 -0.00827 -0.10990 -0.07988 262 LYS A CB  
1118 C CG  . LYS A 82  ? 0.52114 0.64347 0.64035 -0.00662 -0.10316 -0.06983 262 LYS A CG  
1119 C CD  . LYS A 82  ? 0.57246 0.71432 0.73772 -0.01645 -0.10772 -0.06992 262 LYS A CD  
1120 C CE  . LYS A 82  ? 0.52296 0.68675 0.70371 -0.01255 -0.09996 -0.06015 262 LYS A CE  
1129 N N   . GLU A 83  ? 0.32794 0.37067 0.34577 0.00486  -0.09717 -0.08474 263 GLU A N   
1130 C CA  . GLU A 83  ? 0.35662 0.37904 0.35864 0.00804  -0.10628 -0.09751 263 GLU A CA  
1131 C C   . GLU A 83  ? 0.37116 0.38061 0.32554 0.02926  -0.11498 -0.10520 263 GLU A C   
1132 O O   . GLU A 83  ? 0.37218 0.38308 0.30014 0.04044  -0.10330 -0.09419 263 GLU A O   
1133 C CB  . GLU A 83  ? 0.33797 0.34849 0.33428 0.00342  -0.08754 -0.08908 263 GLU A CB  
1134 C CG  . GLU A 83  ? 0.32841 0.34618 0.36294 -0.01441 -0.07717 -0.08053 263 GLU A CG  
1135 C CD  . GLU A 83  ? 0.27028 0.30226 0.31089 -0.01732 -0.05895 -0.06364 263 GLU A CD  
1136 O OE1 . GLU A 83  ? 0.25852 0.29864 0.28530 -0.00913 -0.05704 -0.05903 263 GLU A OE1 
1137 O OE2 . GLU A 83  ? 0.25892 0.29140 0.31547 -0.02651 -0.04662 -0.05497 263 GLU A OE2 
1144 N N   . PRO A 84  ? 0.42973 0.42479 0.37376 0.03532  -0.13036 -0.11927 264 PRO A N   
1145 C CA  . PRO A 84  ? 0.47722 0.45779 0.37426 0.05727  -0.13191 -0.12163 264 PRO A CA  
1146 C C   . PRO A 84  ? 0.47926 0.44869 0.34164 0.06680  -0.11174 -0.11248 264 PRO A C   
1147 O O   . PRO A 84  ? 0.48632 0.44832 0.35419 0.05963  -0.10333 -0.11283 264 PRO A O   
1148 C CB  . PRO A 84  ? 0.66972 0.63540 0.56879 0.05919  -0.14829 -0.13678 264 PRO A CB  
1149 C CG  . PRO A 84  ? 0.65133 0.62435 0.60094 0.03723  -0.15522 -0.14100 264 PRO A CG  
1150 C CD  . PRO A 84  ? 0.49139 0.48539 0.47127 0.02271  -0.14395 -0.12893 264 PRO A CD  
1158 N N   . GLY A 85  ? 0.48205 0.45031 0.31108 0.08329  -0.10219 -0.10261 265 GLY A N   
1159 C CA  . GLY A 85  ? 0.44239 0.40312 0.24479 0.09195  -0.07939 -0.09012 265 GLY A CA  
1160 C C   . GLY A 85  ? 0.45256 0.42630 0.27226 0.08125  -0.06027 -0.07356 265 GLY A C   
1161 O O   . GLY A 85  ? 0.49226 0.46271 0.29980 0.08578  -0.03949 -0.06079 265 GLY A O   
1165 N N   . CYS A 86  ? 0.39517 0.38512 0.25167 0.06551  -0.06449 -0.07076 266 CYS A N   
1166 C CA  . CYS A 86  ? 0.35641 0.35837 0.23432 0.05496  -0.04718 -0.05406 266 CYS A CA  
1167 C C   . CYS A 86  ? 0.32582 0.33868 0.20672 0.05777  -0.05107 -0.04844 266 CYS A C   
1168 O O   . CYS A 86  ? 0.28855 0.31263 0.19407 0.04732  -0.04351 -0.03940 266 CYS A O   
1169 C CB  . CYS A 86  ? 0.29178 0.30110 0.20834 0.03557  -0.04548 -0.05459 266 CYS A CB  
1170 S SG  . CYS A 86  ? 0.39534 0.39024 0.30798 0.03348  -0.03784 -0.05781 266 CYS A SG  
1176 N N   . GLU A 87  ? 0.35899 0.36747 0.21268 0.07376  -0.06341 -0.05405 267 GLU A N   
1177 C CA  . GLU A 87  ? 0.33021 0.34926 0.18857 0.07756  -0.07038 -0.05047 267 GLU A CA  
1178 C C   . GLU A 87  ? 0.35659 0.37572 0.21158 0.07852  -0.05060 -0.03135 267 GLU A C   
1179 O O   . GLU A 87  ? 0.32527 0.35517 0.19992 0.07365  -0.05106 -0.02624 267 GLU A O   
1180 C CB  . GLU A 87  ? 0.46820 0.47964 0.29395 0.09724  -0.08697 -0.05926 267 GLU A CB  
1181 C CG  . GLU A 87  ? 0.43967 0.45171 0.28127 0.09385  -0.10892 -0.07826 267 GLU A CG  
1182 C CD  . GLU A 87  ? 0.41703 0.41219 0.24333 0.09643  -0.10903 -0.08695 267 GLU A CD  
1183 O OE1 . GLU A 87  ? 0.50609 0.49061 0.30929 0.10179  -0.09110 -0.07816 267 GLU A OE1 
1184 O OE2 . GLU A 87  ? 0.52324 0.51580 0.36307 0.09336  -0.12674 -0.10215 267 GLU A OE2 
1191 N N   . THR A 88  ? 0.33209 0.33881 0.16311 0.08587  -0.03315 -0.02049 268 THR A N   
1192 C CA  . THR A 88  ? 0.32747 0.33279 0.16068 0.08515  -0.01509 -0.00226 268 THR A CA  
1193 C C   . THR A 88  ? 0.29358 0.30729 0.16351 0.06601  -0.00596 0.00206  268 THR A C   
1194 O O   . THR A 88  ? 0.27767 0.29414 0.16129 0.06154  -0.00023 0.01103  268 THR A O   
1195 C CB  . THR A 88  ? 0.34125 0.33269 0.14281 0.09877  0.00209  0.00990  268 THR A CB  
1196 O OG1 . THR A 88  ? 0.41047 0.39262 0.18065 0.11578  -0.00767 0.00172  268 THR A OG1 
1197 C CG2 . THR A 88  ? 0.34767 0.33407 0.14537 0.10312  0.01625  0.02878  268 THR A CG2 
1205 N N   . ILE A 89  ? 0.27036 0.28641 0.15488 0.05589  -0.00560 -0.00480 269 ILE A N   
1206 C CA  . ILE A 89  ? 0.25489 0.27926 0.17178 0.03971  -0.00084 -0.00278 269 ILE A CA  
1207 C C   . ILE A 89  ? 0.20673 0.24280 0.14378 0.03402  -0.01109 -0.00671 269 ILE A C   
1208 O O   . ILE A 89  ? 0.20872 0.24941 0.16236 0.02762  -0.00548 -0.00066 269 ILE A O   
1209 C CB  . ILE A 89  ? 0.22844 0.25179 0.15478 0.03202  -0.00017 -0.00950 269 ILE A CB  
1210 C CG1 . ILE A 89  ? 0.27225 0.28666 0.18222 0.03872  0.01287  -0.00367 269 ILE A CG1 
1211 C CG2 . ILE A 89  ? 0.25062 0.28149 0.20552 0.01809  0.00356  -0.00730 269 ILE A CG2 
1212 C CD1 . ILE A 89  ? 0.27521 0.28555 0.18768 0.03580  0.01222  -0.01149 269 ILE A CD1 
1224 N N   . GLY A 90  ? 0.24923 0.29048 0.18588 0.03740  -0.02660 -0.01729 270 GLY A N   
1225 C CA  . GLY A 90  ? 0.25386 0.30959 0.21288 0.03363  -0.03539 -0.02008 270 GLY A CA  
1226 C C   . GLY A 90  ? 0.22659 0.28247 0.17820 0.04171  -0.03225 -0.01125 270 GLY A C   
1227 O O   . GLY A 90  ? 0.22626 0.29147 0.19757 0.03722  -0.03055 -0.00846 270 GLY A O   
1231 N N   . LEU A 91  ? 0.25993 0.30376 0.18113 0.05529  -0.03063 -0.00615 271 LEU A N   
1232 C CA  . LEU A 91  ? 0.26307 0.30261 0.17583 0.06357  -0.02633 0.00418  271 LEU A CA  
1233 C C   . LEU A 91  ? 0.25006 0.28472 0.17622 0.05456  -0.01121 0.01440  271 LEU A C   
1234 O O   . LEU A 91  ? 0.24715 0.28306 0.18313 0.05477  -0.01043 0.01844  271 LEU A O   
1235 C CB  . LEU A 91  ? 0.31595 0.34090 0.19111 0.08088  -0.02489 0.01029  271 LEU A CB  
1236 C CG  . LEU A 91  ? 0.34052 0.35453 0.20327 0.09003  -0.01635 0.02485  271 LEU A CG  
1237 C CD1 . LEU A 91  ? 0.39325 0.41609 0.26539 0.09520  -0.02843 0.02201  271 LEU A CD1 
1238 C CD2 . LEU A 91  ? 0.42087 0.41826 0.24293 0.10807  -0.01054 0.03388  271 LEU A CD2 
1250 N N   . LEU A 92  ? 0.23910 0.26786 0.16652 0.04754  -0.00037 0.01764  272 LEU A N   
1251 C CA  . LEU A 92  ? 0.21744 0.24281 0.16132 0.03840  0.01025  0.02465  272 LEU A CA  
1252 C C   . LEU A 92  ? 0.19599 0.23233 0.16311 0.02988  0.00530  0.01850  272 LEU A C   
1253 O O   . LEU A 92  ? 0.19364 0.22695 0.16899 0.02880  0.00779  0.02218  272 LEU A O   
1254 C CB  . LEU A 92  ? 0.23477 0.25692 0.18103 0.03231  0.01965  0.02654  272 LEU A CB  
1255 C CG  . LEU A 92  ? 0.21032 0.23230 0.17833 0.02133  0.02645  0.02964  272 LEU A CG  
1256 C CD1 . LEU A 92  ? 0.22661 0.23833 0.19879 0.02212  0.03351  0.04040  272 LEU A CD1 
1257 C CD2 . LEU A 92  ? 0.22692 0.25029 0.19938 0.01645  0.03226  0.02850  272 LEU A CD2 
1269 N N   . MET A 93  ? 0.18044 0.22793 0.15771 0.02461  -0.00097 0.00955  273 MET A N   
1270 C CA  . MET A 93  ? 0.16746 0.22587 0.16600 0.01753  -0.00227 0.00596  273 MET A CA  
1271 C C   . MET A 93  ? 0.16599 0.23173 0.16944 0.02409  -0.00722 0.00608  273 MET A C   
1272 O O   . MET A 93  ? 0.16854 0.23581 0.18082 0.02355  -0.00376 0.00783  273 MET A O   
1273 C CB  . MET A 93  ? 0.19137 0.25842 0.19932 0.01202  -0.00788 -0.00180 273 MET A CB  
1274 C CG  . MET A 93  ? 0.19739 0.25639 0.20253 0.00582  -0.00170 -0.00174 273 MET A CG  
1275 S SD  . MET A 93  ? 0.19237 0.25567 0.20855 -0.00087 -0.00835 -0.01074 273 MET A SD  
1276 C CE  . MET A 93  ? 0.17404 0.24867 0.21607 -0.00938 -0.00451 -0.00885 273 MET A CE  
1286 N N   A SER A 94  ? 0.18446 0.25392 0.18002 0.03258  -0.01614 0.00376  274 SER A N   
1287 N N   B SER A 94  ? 0.18378 0.25317 0.17917 0.03260  -0.01617 0.00374  274 SER A N   
1288 C CA  A SER A 94  ? 0.18880 0.26667 0.19032 0.04058  -0.02151 0.00396  274 SER A CA  
1289 C CA  B SER A 94  ? 0.18844 0.26590 0.18872 0.04109  -0.02193 0.00394  274 SER A CA  
1290 C C   A SER A 94  ? 0.19061 0.25323 0.18013 0.04710  -0.01518 0.01235  274 SER A C   
1291 C C   B SER A 94  ? 0.19056 0.25317 0.17981 0.04722  -0.01532 0.01233  274 SER A C   
1292 O O   A SER A 94  ? 0.19299 0.25939 0.19096 0.05116  -0.01528 0.01286  274 SER A O   
1293 O O   B SER A 94  ? 0.19213 0.25885 0.19030 0.05102  -0.01536 0.01273  274 SER A O   
1294 C CB  A SER A 94  ? 0.24395 0.33069 0.24144 0.04915  -0.03551 -0.00182 274 SER A CB  
1295 C CB  B SER A 94  ? 0.24816 0.33181 0.24038 0.05044  -0.03549 -0.00121 274 SER A CB  
1296 O OG  A SER A 94  ? 0.29139 0.36247 0.25893 0.05936  -0.03665 0.00205  274 SER A OG  
1297 O OG  B SER A 94  ? 0.31072 0.40018 0.30395 0.06157  -0.04134 0.00028  274 SER A OG  
1308 N N   . SER A 95  ? 0.21169 0.25648 0.18415 0.04782  -0.00851 0.01932  275 SER A N   
1309 C CA  . SER A 95  ? 0.23679 0.26459 0.20307 0.05175  -0.00222 0.02808  275 SER A CA  
1310 C C   . SER A 95  ? 0.19458 0.21932 0.17632 0.04337  0.00243  0.02674  275 SER A C   
1311 O O   . SER A 95  ? 0.21338 0.22972 0.19711 0.04769  0.00229  0.02818  275 SER A O   
1312 C CB  . SER A 95  ? 0.22288 0.23464 0.17264 0.05324  0.00598  0.03754  275 SER A CB  
1313 O OG  . SER A 95  ? 0.28273 0.29498 0.21111 0.06490  0.00090  0.03828  275 SER A OG  
1319 N N   . MET A 96  ? 0.17675 0.20653 0.16731 0.03306  0.00541  0.02317  276 MET A N   
1320 C CA  . MET A 96  ? 0.17439 0.20186 0.17612 0.02714  0.00766  0.02037  276 MET A CA  
1321 C C   . MET A 96  ? 0.16480 0.20342 0.17298 0.03208  0.00428  0.01525  276 MET A C   
1322 O O   . MET A 96  ? 0.17114 0.20199 0.17958 0.03605  0.00430  0.01408  276 MET A O   
1323 C CB  . MET A 96  ? 0.21101 0.24342 0.21927 0.01751  0.01048  0.01755  276 MET A CB  
1324 C CG  . MET A 96  ? 0.16617 0.19172 0.17164 0.01294  0.01546  0.02206  276 MET A CG  
1325 S SD  . MET A 96  ? 0.21342 0.24757 0.22594 0.00468  0.01677  0.01712  276 MET A SD  
1326 C CE  . MET A 96  ? 0.22316 0.24848 0.23986 0.00020  0.02379  0.02303  276 MET A CE  
1336 N N   . ASP A 97  ? 0.16749 0.22446 0.18231 0.03262  0.00129  0.01198  277 ASP A N   
1337 C CA  . ASP A 97  ? 0.14500 0.21728 0.17151 0.03722  0.00066  0.00896  277 ASP A CA  
1338 C C   . ASP A 97  ? 0.16923 0.23730 0.19091 0.04948  -0.00212 0.01036  277 ASP A C   
1339 O O   . ASP A 97  ? 0.17044 0.24129 0.19584 0.05589  0.00023  0.00876  277 ASP A O   
1340 C CB  . ASP A 97  ? 0.16991 0.26324 0.21099 0.03440  -0.00345 0.00596  277 ASP A CB  
1341 C CG  . ASP A 97  ? 0.15218 0.24934 0.20099 0.02300  -0.00037 0.00430  277 ASP A CG  
1342 O OD1 . ASP A 97  ? 0.16203 0.24952 0.20586 0.01857  0.00569  0.00560  277 ASP A OD1 
1343 O OD2 . ASP A 97  ? 0.16393 0.27356 0.22498 0.01925  -0.00565 0.00101  277 ASP A OD2 
1348 N N   . ASP A 98  ? 0.18988 0.25061 0.20106 0.05508  -0.00674 0.01364  278 ASP A N   
1349 C CA  . ASP A 98  ? 0.18638 0.24014 0.19105 0.06816  -0.00978 0.01610  278 ASP A CA  
1350 C C   . ASP A 98  ? 0.19583 0.22761 0.19457 0.06969  -0.00569 0.01735  278 ASP A C   
1351 O O   . ASP A 98  ? 0.20275 0.23260 0.20203 0.07955  -0.00645 0.01524  278 ASP A O   
1352 C CB  . ASP A 98  ? 0.21893 0.26373 0.20781 0.07419  -0.01414 0.02145  278 ASP A CB  
1353 C CG  . ASP A 98  ? 0.36761 0.40958 0.34956 0.08994  -0.01966 0.02414  278 ASP A CG  
1354 O OD1 . ASP A 98  ? 0.31518 0.37029 0.30884 0.09735  -0.02237 0.02033  278 ASP A OD1 
1355 O OD2 . ASP A 98  ? 0.38287 0.40957 0.34600 0.09683  -0.02080 0.03121  278 ASP A OD2 
1360 N N   . LEU A 99  ? 0.20902 0.22421 0.20386 0.06050  -0.00213 0.01981  279 LEU A N   
1361 C CA  . LEU A 99  ? 0.22568 0.21975 0.21934 0.06053  -0.00140 0.01868  279 LEU A CA  
1362 C C   . LEU A 99  ? 0.20702 0.20804 0.20444 0.06289  -0.00153 0.01031  279 LEU A C   
1363 O O   . LEU A 99  ? 0.23500 0.22469 0.22775 0.07228  -0.00364 0.00658  279 LEU A O   
1364 C CB  . LEU A 99  ? 0.22744 0.20801 0.22385 0.04859  0.00173  0.02230  279 LEU A CB  
1365 C CG  . LEU A 99  ? 0.23112 0.19910 0.22155 0.04891  0.00528  0.03326  279 LEU A CG  
1366 C CD1 . LEU A 99  ? 0.24002 0.20240 0.23887 0.03680  0.01061  0.03708  279 LEU A CD1 
1367 C CD2 . LEU A 99  ? 0.27011 0.21536 0.25643 0.05687  0.00402  0.03790  279 LEU A CD2 
1379 N N   . ILE A 100 ? 0.19970 0.21791 0.20338 0.05598  0.00136  0.00770  280 ILE A N   
1380 C CA  . ILE A 100 ? 0.19468 0.21862 0.19817 0.05993  0.00366  0.00202  280 ILE A CA  
1381 C C   . ILE A 100 ? 0.16882 0.20556 0.17395 0.07352  0.00534  0.00098  280 ILE A C   
1382 O O   . ILE A 100 ? 0.21002 0.24026 0.20733 0.08394  0.00649  -0.00341 280 ILE A O   
1383 C CB  . ILE A 100 ? 0.20182 0.24079 0.21189 0.05039  0.00802  0.00206  280 ILE A CB  
1384 C CG1 . ILE A 100 ? 0.19381 0.21880 0.20177 0.04012  0.00622  0.00164  280 ILE A CG1 
1385 C CG2 . ILE A 100 ? 0.19705 0.24616 0.20603 0.05726  0.01357  -0.00044 280 ILE A CG2 
1386 C CD1 . ILE A 100 ? 0.25665 0.26251 0.25680 0.04369  0.00178  -0.00432 280 ILE A CD1 
1398 N N   A ARG A 101 ? 0.18454 0.23968 0.19977 0.07528  0.00469  0.00429  281 ARG A N   
1399 N N   B ARG A 101 ? 0.18509 0.24006 0.20023 0.07533  0.00464  0.00430  281 ARG A N   
1400 C CA  A ARG A 101 ? 0.18220 0.25364 0.20480 0.08855  0.00622  0.00378  281 ARG A CA  
1401 C CA  B ARG A 101 ? 0.18293 0.25446 0.20560 0.08854  0.00621  0.00379  281 ARG A CA  
1402 C C   A ARG A 101 ? 0.21870 0.27013 0.22821 0.10257  0.00289  0.00221  281 ARG A C   
1403 C C   B ARG A 101 ? 0.21892 0.27091 0.22878 0.10267  0.00279  0.00234  281 ARG A C   
1404 O O   A ARG A 101 ? 0.24327 0.30052 0.25259 0.11623  0.00617  -0.00027 281 ARG A O   
1405 O O   B ARG A 101 ? 0.24078 0.29989 0.25143 0.11651  0.00590  0.00014  281 ARG A O   
1406 C CB  A ARG A 101 ? 0.17933 0.27378 0.21803 0.08800  0.00223  0.00623  281 ARG A CB  
1407 C CB  B ARG A 101 ? 0.17974 0.27507 0.21913 0.08750  0.00243  0.00622  281 ARG A CB  
1408 C CG  A ARG A 101 ? 0.17086 0.28911 0.22937 0.07683  0.00530  0.00645  281 ARG A CG  
1409 C CG  B ARG A 101 ? 0.17229 0.29253 0.23234 0.07734  0.00660  0.00644  281 ARG A CG  
1410 C CD  A ARG A 101 ? 0.18532 0.32863 0.26484 0.08000  -0.00123 0.00631  281 ARG A CD  
1411 C CD  B ARG A 101 ? 0.17977 0.32478 0.26136 0.07807  -0.00038 0.00631  281 ARG A CD  
1412 N NE  A ARG A 101 ? 0.19299 0.35184 0.29074 0.06658  -0.00266 0.00536  281 ARG A NE  
1413 N NE  B ARG A 101 ? 0.12988 0.26501 0.20099 0.07359  -0.01052 0.00561  281 ARG A NE  
1414 C CZ  A ARG A 101 ? 0.14745 0.29798 0.23752 0.05827  -0.01024 0.00352  281 ARG A CZ  
1415 C CZ  B ARG A 101 ? 0.18226 0.31997 0.25725 0.06146  -0.01326 0.00400  281 ARG A CZ  
1416 N NH1 A ARG A 101 ? 0.17069 0.30033 0.23643 0.06224  -0.01544 0.00436  281 ARG A NH1 
1417 N NH1 B ARG A 101 ? 0.18841 0.33861 0.28107 0.05118  -0.00759 0.00337  281 ARG A NH1 
1418 N NH2 A ARG A 101 ? 0.14045 0.30250 0.24723 0.04661  -0.01162 0.00142  281 ARG A NH2 
1419 N NH2 B ARG A 101 ? 0.17511 0.30082 0.23407 0.06099  -0.02097 0.00361  281 ARG A NH2 
1446 N N   . HIS A 102 ? 0.22663 0.25380 0.22577 0.10026  -0.00256 0.00451  282 HIS A N   
1447 C CA  . HIS A 102 ? 0.26825 0.27100 0.25588 0.11234  -0.00608 0.00345  282 HIS A CA  
1448 C C   . HIS A 102 ? 0.25117 0.23192 0.22895 0.11415  -0.00667 -0.00393 282 HIS A C   
1449 O O   . HIS A 102 ? 0.27277 0.23165 0.24094 0.12580  -0.01045 -0.00748 282 HIS A O   
1450 C CB  . HIS A 102 ? 0.24865 0.23113 0.23034 0.10852  -0.00979 0.01071  282 HIS A CB  
1451 C CG  . HIS A 102 ? 0.26074 0.25681 0.24310 0.11581  -0.01254 0.01649  282 HIS A CG  
1452 N ND1 . HIS A 102 ? 0.25354 0.27228 0.24274 0.10904  -0.01342 0.01830  282 HIS A ND1 
1453 C CD2 . HIS A 102 ? 0.29040 0.27918 0.26617 0.13081  -0.01645 0.01987  282 HIS A CD2 
1454 C CE1 . HIS A 102 ? 0.25940 0.28449 0.24542 0.11984  -0.01907 0.02180  282 HIS A CE1 
1455 N NE2 . HIS A 102 ? 0.28265 0.29079 0.26056 0.13351  -0.02051 0.02354  282 HIS A NE2 
1463 N N   . CYS A 103 ? 0.28278 0.26653 0.26162 0.10353  -0.00469 -0.00702 283 CYS A N   
1464 C CA  . CYS A 103 ? 0.34438 0.31062 0.31183 0.10736  -0.00734 -0.01609 283 CYS A CA  
1465 C C   . CYS A 103 ? 0.32295 0.30498 0.28314 0.12030  -0.00071 -0.02055 283 CYS A C   
1466 O O   . CYS A 103 ? 0.36997 0.33883 0.31578 0.12517  -0.00293 -0.02843 283 CYS A O   
1467 C CB  . CYS A 103 ? 0.33473 0.29490 0.30548 0.09161  -0.00974 -0.01716 283 CYS A CB  
1468 S SG  . CYS A 103 ? 0.35706 0.29801 0.33785 0.07727  -0.01435 -0.01122 283 CYS A SG  
1474 N N   . ASN A 104 ? 0.38282 0.40555 0.41200 0.07749  -0.02981 0.01082  284 ASN A N   
1475 C CA  . ASN A 104 ? 0.30788 0.35315 0.35985 0.06612  -0.02604 -0.00385 284 ASN A CA  
1476 C C   . ASN A 104 ? 0.31934 0.36169 0.38088 0.06238  -0.01887 -0.00822 284 ASN A C   
1477 O O   . ASN A 104 ? 0.32066 0.35655 0.38843 0.07323  -0.02232 -0.01015 284 ASN A O   
1478 C CB  . ASN A 104 ? 0.27467 0.34367 0.34861 0.07481  -0.03568 -0.02060 284 ASN A CB  
1481 N N   . GLY A 105 ? 0.30139 0.34683 0.36115 0.04961  -0.00908 -0.01046 285 GLY A N   
1482 C CA  . GLY A 105 ? 0.25406 0.29945 0.31937 0.04809  -0.00335 -0.01804 285 GLY A CA  
1483 C C   . GLY A 105 ? 0.29167 0.32061 0.35437 0.04979  -0.00452 -0.01494 285 GLY A C   
1484 O O   . GLY A 105 ? 0.29720 0.32721 0.36845 0.05065  -0.00214 -0.02503 285 GLY A O   
1488 N N   . LYS A 106 ? 0.22796 0.24177 0.28303 0.05009  -0.00605 -0.00361 286 LYS A N   
1489 C CA  . LYS A 106 ? 0.20921 0.20668 0.27279 0.04932  -0.00233 -0.00380 286 LYS A CA  
1490 C C   . LYS A 106 ? 0.19019 0.18621 0.25035 0.04075  -0.00062 -0.00352 286 LYS A C   
1491 O O   . LYS A 106 ? 0.24041 0.22757 0.31792 0.03806  0.00320  -0.00985 286 LYS A O   
1492 C CB  . LYS A 106 ? 0.26196 0.23569 0.32504 0.05898  0.00073  0.00841  286 LYS A CB  
1493 C CG  . LYS A 106 ? 0.33591 0.30949 0.40158 0.07325  -0.00442 0.00681  286 LYS A CG  
1494 C CD  . LYS A 106 ? 0.42438 0.36959 0.49849 0.08274  0.00301  0.01094  286 LYS A CD  
1495 C CE  . LYS A 106 ? 0.55238 0.50268 0.63416 0.09739  -0.00439 0.00350  286 LYS A CE  
1496 N NZ  . LYS A 106 ? 0.45717 0.37394 0.52729 0.11832  -0.00150 0.01665  286 LYS A NZ  
1510 N N   . LEU A 107 ? 0.21734 0.22233 0.26082 0.03676  -0.00296 0.00076  287 LEU A N   
1511 C CA  . LEU A 107 ? 0.19457 0.20030 0.23396 0.03144  -0.00382 -0.00065 287 LEU A CA  
1512 C C   . LEU A 107 ? 0.23040 0.24825 0.26028 0.03305  -0.00746 -0.01316 287 LEU A C   
1513 O O   . LEU A 107 ? 0.23340 0.25583 0.24273 0.03376  -0.00568 -0.00931 287 LEU A O   
1514 C CB  . LEU A 107 ? 0.22305 0.22757 0.24677 0.02914  -0.00397 0.01180  287 LEU A CB  
1515 C CG  . LEU A 107 ? 0.22491 0.21465 0.24841 0.03185  -0.00005 0.02429  287 LEU A CG  
1516 C CD1 . LEU A 107 ? 0.26667 0.25922 0.27309 0.03132  -0.00230 0.03303  287 LEU A CD1 
1517 C CD2 . LEU A 107 ? 0.25275 0.22850 0.29332 0.02837  0.00829  0.02331  287 LEU A CD2 
1529 N N   . GLY A 108 ? 0.21977 0.24071 0.26372 0.03534  -0.01103 -0.02917 288 GLY A N   
1530 C CA  . GLY A 108 ? 0.28061 0.31152 0.30713 0.04296  -0.01616 -0.04266 288 GLY A CA  
1531 C C   . GLY A 108 ? 0.26638 0.29903 0.27721 0.04579  -0.00892 -0.03949 288 GLY A C   
1532 O O   . GLY A 108 ? 0.29630 0.32816 0.32336 0.04353  -0.00465 -0.03729 288 GLY A O   
1536 N N   . SER A 109 ? 0.28174 0.31484 0.25985 0.05242  -0.00557 -0.03924 289 SER A N   
1537 C CA  . SER A 109 ? 0.29704 0.32952 0.26190 0.05369  0.00806  -0.03627 289 SER A CA  
1538 C C   . SER A 109 ? 0.28220 0.30911 0.23833 0.04680  0.01981  -0.02062 289 SER A C   
1539 O O   . SER A 109 ? 0.28867 0.31221 0.23332 0.04703  0.03643  -0.01854 289 SER A O   
1540 C CB  . SER A 109 ? 0.37132 0.40171 0.30213 0.06779  0.01077  -0.04606 289 SER A CB  
1541 O OG  . SER A 109 ? 0.55489 0.57640 0.45067 0.07621  0.00798  -0.04015 289 SER A OG  
1547 N N   . TYR A 110 ? 0.24996 0.27525 0.21446 0.04043  0.01384  -0.01143 290 TYR A N   
1548 C CA  . TYR A 110 ? 0.25441 0.27547 0.21405 0.03429  0.02291  -0.00033 290 TYR A CA  
1549 C C   . TYR A 110 ? 0.24446 0.27524 0.23310 0.02786  0.02780  -0.00229 290 TYR A C   
1550 O O   . TYR A 110 ? 0.27319 0.31150 0.28297 0.02944  0.01985  -0.00768 290 TYR A O   
1551 C CB  . TYR A 110 ? 0.22674 0.24456 0.18529 0.03162  0.01334  0.00723  290 TYR A CB  
1552 C CG  . TYR A 110 ? 0.25836 0.27096 0.19516 0.03945  0.00552  0.00527  290 TYR A CG  
1553 C CD1 . TYR A 110 ? 0.27120 0.27326 0.17270 0.04898  0.01194  0.00760  290 TYR A CD1 
1554 C CD2 . TYR A 110 ? 0.26658 0.28339 0.21895 0.03900  -0.00680 0.00039  290 TYR A CD2 
1555 C CE1 . TYR A 110 ? 0.28254 0.28189 0.16189 0.06174  0.00010  0.00269  290 TYR A CE1 
1556 C CE2 . TYR A 110 ? 0.26425 0.28199 0.20570 0.04717  -0.01638 -0.00703 290 TYR A CE2 
1557 C CZ  . TYR A 110 ? 0.30386 0.31468 0.20818 0.05996  -0.01585 -0.00677 290 TYR A CZ  
1558 O OH  . TYR A 110 ? 0.32846 0.34223 0.22000 0.07340  -0.02992 -0.01724 290 TYR A OH  
1568 N N   . LYS A 111 ? 0.24798 0.27798 0.23968 0.02223  0.04155  -0.00002 291 LYS A N   
1569 C CA  . LYS A 111 ? 0.22358 0.26808 0.25025 0.01691  0.04384  -0.00772 291 LYS A CA  
1570 C C   . LYS A 111 ? 0.21971 0.26278 0.24919 0.01181  0.04160  -0.00254 291 LYS A C   
1571 O O   . LYS A 111 ? 0.25431 0.28811 0.27859 0.00613  0.05786  0.00062  291 LYS A O   
1572 C CB  . LYS A 111 ? 0.29549 0.34283 0.33575 0.01279  0.06659  -0.01621 291 LYS A CB  
1573 C CG  . LYS A 111 ? 0.40933 0.47980 0.49637 0.01077  0.06478  -0.03316 291 LYS A CG  
1574 C CD  . LYS A 111 ? 0.52229 0.59644 0.62452 0.00811  0.08809  -0.04386 291 LYS A CD  
1575 C CE  . LYS A 111 ? 0.56453 0.62330 0.66277 -0.00106 0.12141  -0.04045 291 LYS A CE  
1576 N NZ  . LYS A 111 ? 0.65327 0.71901 0.78605 -0.01145 0.12687  -0.04691 291 LYS A NZ  
1590 N N   . ILE A 112 ? 0.17759 0.22581 0.21168 0.01515  0.02379  -0.00073 292 ILE A N   
1591 C CA  . ILE A 112 ? 0.18900 0.23547 0.22077 0.01241  0.01968  0.00367  292 ILE A CA  
1592 C C   . ILE A 112 ? 0.20712 0.27163 0.27240 0.01088  0.01812  -0.01105 292 ILE A C   
1593 O O   . ILE A 112 ? 0.28140 0.35986 0.36166 0.01981  0.00408  -0.02015 292 ILE A O   
1594 C CB  . ILE A 112 ? 0.19392 0.23447 0.21023 0.01841  0.00483  0.01261  292 ILE A CB  
1595 C CG1 . ILE A 112 ? 0.25703 0.28511 0.25281 0.01870  0.00628  0.01987  292 ILE A CG1 
1596 C CG2 . ILE A 112 ? 0.24004 0.28133 0.25507 0.01709  0.00055  0.01462  292 ILE A CG2 
1597 C CD1 . ILE A 112 ? 0.30907 0.33060 0.30013 0.02234  -0.00256 0.02576  292 ILE A CD1 
1609 N N   . ASN A 113 ? 0.20973 0.27314 0.28800 0.00154  0.03231  -0.01526 293 ASN A N   
1610 C CA  . ASN A 113 ? 0.21724 0.30119 0.33971 -0.00217 0.03348  -0.03630 293 ASN A CA  
1611 C C   . ASN A 113 ? 0.16640 0.25107 0.29368 -0.00474 0.02864  -0.03904 293 ASN A C   
1612 O O   . ASN A 113 ? 0.16406 0.26908 0.33166 -0.00625 0.02547  -0.06112 293 ASN A O   
1613 C CB  . ASN A 113 ? 0.21173 0.29460 0.36293 -0.01414 0.06280  -0.04588 293 ASN A CB  
1614 C CG  . ASN A 113 ? 0.43989 0.49300 0.56807 -0.02301 0.08862  -0.03037 293 ASN A CG  
1615 O OD1 . ASN A 113 ? 0.41501 0.44877 0.50007 -0.01855 0.08296  -0.01135 293 ASN A OD1 
1616 N ND2 . ASN A 113 ? 0.48079 0.52826 0.63909 -0.03427 0.11938  -0.03928 293 ASN A ND2 
1623 N N   . GLY A 114 ? 0.15318 0.21795 0.24492 -0.00511 0.02838  -0.02056 294 GLY A N   
1624 C CA  . GLY A 114 ? 0.16028 0.22348 0.25817 -0.00892 0.02802  -0.02367 294 GLY A CA  
1625 C C   . GLY A 114 ? 0.14701 0.19189 0.20355 -0.00523 0.02202  -0.00357 294 GLY A C   
1626 O O   . GLY A 114 ? 0.15942 0.19473 0.18835 -0.00057 0.01854  0.00992  294 GLY A O   
1631 N N   . ARG A 115 ? 0.15018 0.19292 0.20875 -0.00719 0.02022  -0.00546 295 ARG A N   
1632 C CA  . ARG A 115 ? 0.15061 0.17887 0.17682 -0.00387 0.01513  0.01015  295 ARG A CA  
1633 C C   . ARG A 115 ? 0.15397 0.17471 0.18833 -0.00950 0.02243  0.00707  295 ARG A C   
1634 O O   . ARG A 115 ? 0.16040 0.18917 0.22862 -0.01588 0.02930  -0.00929 295 ARG A O   
1635 C CB  . ARG A 115 ? 0.18608 0.22241 0.19767 0.00686  -0.00362 0.01233  295 ARG A CB  
1636 C CG  . ARG A 115 ? 0.19764 0.25199 0.22427 0.01429  -0.01680 -0.00391 295 ARG A CG  
1637 C CD  . ARG A 115 ? 0.21240 0.26260 0.21124 0.02562  -0.02779 0.00359  295 ARG A CD  
1638 N NE  . ARG A 115 ? 0.22788 0.29380 0.22883 0.04040  -0.04363 -0.01173 295 ARG A NE  
1639 C CZ  . ARG A 115 ? 0.20208 0.28288 0.22245 0.04197  -0.05052 -0.03154 295 ARG A CZ  
1640 N NH1 . ARG A 115 ? 0.17142 0.24881 0.21068 0.02754  -0.03958 -0.03542 295 ARG A NH1 
1641 N NH2 . ARG A 115 ? 0.24728 0.34496 0.26576 0.06105  -0.06940 -0.04865 295 ARG A NH2 
1655 N N   . THR A 116 ? 0.16873 0.17572 0.17652 -0.00655 0.01998  0.02019  296 THR A N   
1656 C CA  . THR A 116 ? 0.19132 0.19119 0.20311 -0.00909 0.02303  0.01800  296 THR A CA  
1657 C C   . THR A 116 ? 0.16075 0.18034 0.18473 -0.00467 0.00726  0.00395  296 THR A C   
1658 O O   . THR A 116 ? 0.16287 0.19608 0.17993 0.00393  -0.00660 0.00149  296 THR A O   
1659 C CB  . THR A 116 ? 0.16864 0.15202 0.14997 -0.00418 0.02165  0.03343  296 THR A CB  
1660 O OG1 . THR A 116 ? 0.18732 0.18064 0.15610 0.00209  0.00729  0.03662  296 THR A OG1 
1661 C CG2 . THR A 116 ? 0.21147 0.17546 0.17115 -0.00148 0.03245  0.04570  296 THR A CG2 
1669 N N   . LYS A 117 ? 0.17082 0.18871 0.20841 -0.00783 0.00984  -0.00486 297 LYS A N   
1670 C CA  . LYS A 117 ? 0.16166 0.19270 0.19644 0.00014  -0.00547 -0.01470 297 LYS A CA  
1671 C C   . LYS A 117 ? 0.18373 0.20685 0.18196 0.00781  -0.01132 0.00287  297 LYS A C   
1672 O O   . LYS A 117 ? 0.18270 0.19222 0.16485 0.00587  -0.00521 0.01890  297 LYS A O   
1673 C CB  . LYS A 117 ? 0.16981 0.19651 0.22649 -0.00590 0.00119  -0.02664 297 LYS A CB  
1674 C CG  . LYS A 117 ? 0.17425 0.21196 0.28098 -0.01486 0.00902  -0.05145 297 LYS A CG  
1675 C CD  . LYS A 117 ? 0.20388 0.23419 0.33640 -0.02160 0.01792  -0.06433 297 LYS A CD  
1676 C CE  . LYS A 117 ? 0.21203 0.25295 0.40514 -0.03307 0.03014  -0.09213 297 LYS A CE  
1677 N NZ  . LYS A 117 ? 0.27963 0.30853 0.50424 -0.04178 0.04382  -0.10519 297 LYS A NZ  
1691 N N   . ALA A 118 ? 0.17122 0.20336 0.15751 0.01809  -0.02248 -0.00254 298 ALA A N   
1692 C CA  . ALA A 118 ? 0.18835 0.21128 0.14618 0.02376  -0.02192 0.01258  298 ALA A CA  
1693 C C   . ALA A 118 ? 0.18938 0.20294 0.14758 0.01925  -0.01614 0.01541  298 ALA A C   
1694 O O   . ALA A 118 ? 0.22570 0.24219 0.19702 0.01799  -0.01711 0.00315  298 ALA A O   
1695 C CB  . ALA A 118 ? 0.22866 0.25785 0.16489 0.03946  -0.03074 0.00931  298 ALA A CB  
1701 N N   . MET A 119 ? 0.19211 0.19599 0.14021 0.01788  -0.01112 0.02833  299 MET A N   
1702 C CA  . MET A 119 ? 0.17511 0.17200 0.12278 0.01738  -0.00802 0.03007  299 MET A CA  
1703 C C   . MET A 119 ? 0.19395 0.19421 0.13025 0.02349  -0.00710 0.03137  299 MET A C   
1704 O O   . MET A 119 ? 0.22079 0.21931 0.15220 0.02439  -0.00271 0.03891  299 MET A O   
1705 C CB  . MET A 119 ? 0.21853 0.20564 0.16502 0.01588  -0.00524 0.03858  299 MET A CB  
1706 C CG  . MET A 119 ? 0.22523 0.20548 0.17241 0.01911  -0.00492 0.03807  299 MET A CG  
1707 S SD  . MET A 119 ? 0.22832 0.20128 0.16949 0.02568  -0.00819 0.04324  299 MET A SD  
1708 C CE  . MET A 119 ? 0.23598 0.22473 0.18693 0.02472  -0.01023 0.04085  299 MET A CE  
1718 N N   . VAL A 120 ? 0.19964 0.20319 0.13334 0.02773  -0.00853 0.02300  300 VAL A N   
1719 C CA  . VAL A 120 ? 0.21142 0.21450 0.13150 0.03443  -0.00293 0.02457  300 VAL A CA  
1720 C C   . VAL A 120 ? 0.20709 0.20711 0.14070 0.03027  0.00139  0.02483  300 VAL A C   
1721 O O   . VAL A 120 ? 0.22470 0.22283 0.16841 0.02853  -0.00222 0.01853  300 VAL A O   
1722 C CB  . VAL A 120 ? 0.22420 0.23344 0.13153 0.04449  -0.00818 0.01255  300 VAL A CB  
1723 C CG1 . VAL A 120 ? 0.25100 0.25576 0.13870 0.05296  0.00198  0.01548  300 VAL A CG1 
1724 C CG2 . VAL A 120 ? 0.26583 0.28123 0.16092 0.05330  -0.01718 0.00813  300 VAL A CG2 
1734 N N   . ALA A 121 ? 0.20939 0.20849 0.14726 0.02943  0.00965  0.03016  301 ALA A N   
1735 C CA  . ALA A 121 ? 0.22653 0.22752 0.18313 0.02790  0.01036  0.02636  301 ALA A CA  
1736 C C   . ALA A 121 ? 0.22217 0.22630 0.18596 0.02937  0.02361  0.02318  301 ALA A C   
1737 O O   . ALA A 121 ? 0.22826 0.22881 0.18709 0.02916  0.03745  0.02843  301 ALA A O   
1738 C CB  . ALA A 121 ? 0.22234 0.22456 0.19165 0.02554  0.00605  0.02829  301 ALA A CB  
1744 N N   . CYS A 122 ? 0.19285 0.20106 0.17021 0.03129  0.02202  0.01472  302 CYS A N   
1745 C CA  . CYS A 122 ? 0.22567 0.23902 0.21767 0.03199  0.03619  0.00838  302 CYS A CA  
1746 C C   . CYS A 122 ? 0.17964 0.20362 0.20538 0.03265  0.02972  -0.00292 302 CYS A C   
1747 O O   . CYS A 122 ? 0.18269 0.20554 0.20881 0.03809  0.01529  -0.00675 302 CYS A O   
1748 C CB  . CYS A 122 ? 0.20531 0.21682 0.18154 0.03752  0.03922  0.00394  302 CYS A CB  
1749 S SG  . CYS A 122 ? 0.24510 0.26304 0.24105 0.03921  0.05744  -0.00618 302 CYS A SG  
1755 N N   . TYR A 123 ? 0.17878 0.21204 0.23463 0.02891  0.04133  -0.01013 303 TYR A N   
1756 C CA  . TYR A 123 ? 0.17409 0.22374 0.26970 0.03228  0.03599  -0.02827 303 TYR A CA  
1757 C C   . TYR A 123 ? 0.18549 0.23865 0.29370 0.03135  0.05508  -0.03535 303 TYR A C   
1758 O O   . TYR A 123 ? 0.19748 0.24670 0.31176 0.02475  0.08121  -0.03275 303 TYR A O   
1759 C CB  . TYR A 123 ? 0.16729 0.22974 0.30029 0.02803  0.03806  -0.03909 303 TYR A CB  
1760 C CG  . TYR A 123 ? 0.15935 0.21974 0.27847 0.03177  0.01783  -0.03471 303 TYR A CG  
1761 C CD1 . TYR A 123 ? 0.15816 0.20525 0.25099 0.02572  0.02268  -0.01845 303 TYR A CD1 
1762 C CD2 . TYR A 123 ? 0.15856 0.22925 0.28759 0.04456  -0.00620 -0.04747 303 TYR A CD2 
1763 C CE1 . TYR A 123 ? 0.15282 0.19819 0.23357 0.02911  0.00653  -0.01532 303 TYR A CE1 
1764 C CE2 . TYR A 123 ? 0.16960 0.23553 0.27913 0.05061  -0.02218 -0.04282 303 TYR A CE2 
1765 C CZ  . TYR A 123 ? 0.16724 0.22130 0.25491 0.04143  -0.01464 -0.02713 303 TYR A CZ  
1766 O OH  . TYR A 123 ? 0.18316 0.23232 0.25149 0.04709  -0.02784 -0.02290 303 TYR A OH  
1776 N N   . PRO A 124 ? 0.19140 0.24800 0.30084 0.03866  0.04620  -0.04302 304 PRO A N   
1777 C CA  . PRO A 124 ? 0.20164 0.25928 0.31413 0.03883  0.06505  -0.04841 304 PRO A CA  
1778 C C   . PRO A 124 ? 0.20199 0.27902 0.36888 0.03687  0.07789  -0.06877 304 PRO A C   
1779 O O   . PRO A 124 ? 0.21435 0.30176 0.40122 0.04291  0.07509  -0.08308 304 PRO A O   
1780 C CB  . PRO A 124 ? 0.20625 0.25944 0.30218 0.04766  0.04747  -0.05042 304 PRO A CB  
1781 C CG  . PRO A 124 ? 0.21249 0.26765 0.31822 0.05440  0.02305  -0.05333 304 PRO A CG  
1782 C CD  . PRO A 124 ? 0.18406 0.23730 0.28361 0.04886  0.02059  -0.04419 304 PRO A CD  
1790 N N   . GLY A 125 ? 0.19485 0.20675 0.26858 0.02361  0.08439  -0.04454 305 GLY A N   
1791 C CA  . GLY A 125 ? 0.21018 0.24046 0.29883 0.02868  0.08907  -0.03682 305 GLY A CA  
1792 C C   . GLY A 125 ? 0.25335 0.28536 0.36303 0.03904  0.09050  -0.02988 305 GLY A C   
1793 O O   . GLY A 125 ? 0.21969 0.24225 0.33244 0.04040  0.08414  -0.02525 305 GLY A O   
1797 N N   . ASN A 126 ? 0.24782 0.29491 0.37246 0.04778  0.09949  -0.02735 306 ASN A N   
1798 C CA  . ASN A 126 ? 0.22450 0.27720 0.37004 0.06162  0.10293  -0.01913 306 ASN A CA  
1799 C C   . ASN A 126 ? 0.19641 0.26519 0.35236 0.06148  0.09023  -0.00650 306 ASN A C   
1800 O O   . ASN A 126 ? 0.23541 0.30663 0.40424 0.07400  0.09080  0.00260  306 ASN A O   
1801 C CB  . ASN A 126 ? 0.21301 0.23595 0.35592 0.06945  0.11165  -0.02535 306 ASN A CB  
1802 C CG  . ASN A 126 ? 0.25460 0.26609 0.38477 0.06816  0.12134  -0.03978 306 ASN A CG  
1803 O OD1 . ASN A 126 ? 0.28838 0.31720 0.42153 0.07122  0.12680  -0.04039 306 ASN A OD1 
1804 N ND2 . ASN A 126 ? 0.29579 0.28112 0.41166 0.06241  0.12304  -0.05223 306 ASN A ND2 
1811 N N   . GLY A 127 ? 0.18243 0.26417 0.33364 0.04854  0.08004  -0.00547 307 GLY A N   
1812 C CA  . GLY A 127 ? 0.16341 0.26339 0.32323 0.04655  0.06814  0.00269  307 GLY A CA  
1813 C C   . GLY A 127 ? 0.20133 0.28336 0.34998 0.04544  0.05998  0.00484  307 GLY A C   
1814 O O   . GLY A 127 ? 0.20913 0.30787 0.36378 0.04641  0.05062  0.01189  307 GLY A O   
1818 N N   . THR A 128 ? 0.19237 0.24438 0.32529 0.04293  0.06327  -0.00178 308 THR A N   
1819 C CA  . THR A 128 ? 0.21283 0.24811 0.33612 0.04058  0.05682  -0.00003 308 THR A CA  
1820 C C   . THR A 128 ? 0.20479 0.24793 0.31924 0.02820  0.04501  -0.00041 308 THR A C   
1821 O O   . THR A 128 ? 0.19816 0.24675 0.30818 0.01909  0.04422  -0.00489 308 THR A O   
1822 C CB  . THR A 128 ? 0.19776 0.20297 0.30883 0.03811  0.06366  -0.00995 308 THR A CB  
1823 O OG1 . THR A 128 ? 0.22694 0.23100 0.32437 0.02818  0.06404  -0.02040 308 THR A OG1 
1824 C CG2 . THR A 128 ? 0.25041 0.24202 0.37129 0.04983  0.07762  -0.01170 308 THR A CG2 
1832 N N   . GLY A 129 ? 0.18333 0.22508 0.29504 0.02868  0.03759  0.00488  309 GLY A N   
1833 C CA  . GLY A 129 ? 0.14417 0.19020 0.24735 0.01839  0.02782  0.00341  309 GLY A CA  
1834 C C   . GLY A 129 ? 0.16443 0.20327 0.26189 0.02120  0.02301  0.00856  309 GLY A C   
1835 O O   . GLY A 129 ? 0.16495 0.18788 0.26242 0.02818  0.02857  0.01200  309 GLY A O   
1839 N N   . TYR A 130 ? 0.13438 0.18452 0.22774 0.01550  0.01417  0.00872  310 TYR A N   
1840 C CA  . TYR A 130 ? 0.13606 0.18148 0.22164 0.01756  0.00979  0.01350  310 TYR A CA  
1841 C C   . TYR A 130 ? 0.15013 0.22395 0.23829 0.01658  0.00074  0.01502  310 TYR A C   
1842 O O   . TYR A 130 ? 0.14158 0.22331 0.22888 0.00583  -0.00336 0.00638  310 TYR A O   
1843 C CB  . TYR A 130 ? 0.16812 0.19300 0.23992 0.00861  0.00898  0.00700  310 TYR A CB  
1844 C CG  . TYR A 130 ? 0.15396 0.16772 0.21872 0.01068  0.00850  0.01131  310 TYR A CG  
1845 C CD1 . TYR A 130 ? 0.14569 0.17165 0.21124 0.01779  0.00558  0.02072  310 TYR A CD1 
1846 C CD2 . TYR A 130 ? 0.17248 0.16777 0.22976 0.00535  0.01091  0.00619  310 TYR A CD2 
1847 C CE1 . TYR A 130 ? 0.16656 0.18245 0.22565 0.01939  0.00691  0.02590  310 TYR A CE1 
1848 C CE2 . TYR A 130 ? 0.18174 0.16864 0.23489 0.00572  0.01148  0.00972  310 TYR A CE2 
1849 C CZ  . TYR A 130 ? 0.16533 0.16092 0.21947 0.01260  0.01024  0.01996  310 TYR A CZ  
1850 O OH  . TYR A 130 ? 0.17526 0.16284 0.22548 0.01286  0.01252  0.02473  310 TYR A OH  
1860 N N   . VAL A 131 ? 0.13461 0.22477 0.22648 0.02778  -0.00134 0.02560  311 VAL A N   
1861 C CA  . VAL A 131 ? 0.12998 0.25435 0.22321 0.02771  -0.01093 0.02596  311 VAL A CA  
1862 C C   . VAL A 131 ? 0.13423 0.25318 0.21337 0.01654  -0.01663 0.01699  311 VAL A C   
1863 O O   . VAL A 131 ? 0.14210 0.23321 0.21061 0.01322  -0.01334 0.01560  311 VAL A O   
1864 C CB  . VAL A 131 ? 0.13388 0.27713 0.22963 0.04489  -0.01157 0.04238  311 VAL A CB  
1865 C CG1 . VAL A 131 ? 0.13508 0.28442 0.24644 0.05858  -0.00458 0.05248  311 VAL A CG1 
1866 C CG2 . VAL A 131 ? 0.17063 0.28786 0.25414 0.04940  -0.00697 0.05056  311 VAL A CG2 
1876 N N   . ARG A 132 ? 0.14151 0.28980 0.22166 0.01075  -0.02488 0.00972  312 ARG A N   
1877 C CA  . ARG A 132 ? 0.15043 0.29385 0.21810 0.00037  -0.02885 -0.00100 312 ARG A CA  
1878 C C   . ARG A 132 ? 0.13924 0.27153 0.19237 0.00809  -0.02836 0.00769  312 ARG A C   
1879 O O   . ARG A 132 ? 0.17256 0.32101 0.22448 0.02085  -0.02951 0.02082  312 ARG A O   
1880 C CB  . ARG A 132 ? 0.20083 0.38248 0.27313 -0.00644 -0.03738 -0.01174 312 ARG A CB  
1881 C CG  . ARG A 132 ? 0.13810 0.31449 0.20005 -0.01928 -0.03973 -0.02748 312 ARG A CG  
1882 C CD  . ARG A 132 ? 0.30962 0.53233 0.37406 -0.02205 -0.04937 -0.03634 312 ARG A CD  
1883 N NE  . ARG A 132 ? 0.49862 0.71912 0.55705 -0.03712 -0.05030 -0.05658 312 ARG A NE  
1884 C CZ  . ARG A 132 ? 0.54870 0.76955 0.58979 -0.03534 -0.05221 -0.06027 312 ARG A CZ  
1885 N NH1 . ARG A 132 ? 0.42021 0.64821 0.44918 -0.02071 -0.05487 -0.04501 312 ARG A NH1 
1886 N NH2 . ARG A 132 ? 0.28925 0.49981 0.32553 -0.04756 -0.04908 -0.07827 312 ARG A NH2 
1900 N N   . HIS A 133 ? 0.13711 0.24319 0.18027 0.00128  -0.02558 0.00188  313 HIS A N   
1901 C CA  . HIS A 133 ? 0.14255 0.23631 0.17399 0.00673  -0.02341 0.00926  313 HIS A CA  
1902 C C   . HIS A 133 ? 0.13895 0.21630 0.16052 -0.00214 -0.02275 -0.00123 313 HIS A C   
1903 O O   . HIS A 133 ? 0.15840 0.22734 0.18226 -0.01163 -0.02223 -0.01256 313 HIS A O   
1904 C CB  . HIS A 133 ? 0.15141 0.22119 0.18667 0.01304  -0.01543 0.02000  313 HIS A CB  
1905 C CG  . HIS A 133 ? 0.14288 0.18861 0.18063 0.00538  -0.01126 0.01248  313 HIS A CG  
1906 N ND1 . HIS A 133 ? 0.15579 0.20196 0.20240 0.00255  -0.01007 0.00823  313 HIS A ND1 
1907 C CD2 . HIS A 133 ? 0.16481 0.18964 0.19711 0.00095  -0.00797 0.00924  313 HIS A CD2 
1908 C CE1 . HIS A 133 ? 0.19155 0.21768 0.23593 -0.00275 -0.00616 0.00323  313 HIS A CE1 
1909 N NE2 . HIS A 133 ? 0.16923 0.18377 0.20519 -0.00384 -0.00560 0.00336  313 HIS A NE2 
1917 N N   . VAL A 134 ? 0.16422 0.23639 0.17581 0.00206  -0.02109 0.00416  314 VAL A N   
1918 C CA  . VAL A 134 ? 0.17179 0.22876 0.17470 -0.00284 -0.01889 -0.00262 314 VAL A CA  
1919 C C   . VAL A 134 ? 0.16967 0.20575 0.17420 -0.00034 -0.01284 0.00535  314 VAL A C   
1920 O O   . VAL A 134 ? 0.17802 0.21386 0.18548 0.00610  -0.00968 0.01686  314 VAL A O   
1921 C CB  . VAL A 134 ? 0.16170 0.23682 0.15252 -0.00023 -0.02170 -0.00419 314 VAL A CB  
1922 C CG1 . VAL A 134 ? 0.16946 0.22957 0.15201 -0.00191 -0.01747 -0.00784 314 VAL A CG1 
1923 C CG2 . VAL A 134 ? 0.17897 0.27790 0.16885 -0.00570 -0.02819 -0.01723 314 VAL A CG2 
1933 N N   . ASP A 135 ? 0.16405 0.18375 0.16809 -0.00529 -0.01042 -0.00058 315 ASP A N   
1934 C CA  . ASP A 135 ? 0.17202 0.17809 0.17930 -0.00474 -0.00585 0.00406  315 ASP A CA  
1935 C C   . ASP A 135 ? 0.17022 0.17856 0.17361 -0.00145 -0.00283 0.01060  315 ASP A C   
1936 O O   . ASP A 135 ? 0.19734 0.19956 0.20665 -0.00027 0.00207  0.01766  315 ASP A O   
1937 C CB  . ASP A 135 ? 0.17790 0.17333 0.18485 -0.00886 -0.00495 -0.00247 315 ASP A CB  
1938 C CG  . ASP A 135 ? 0.20037 0.19045 0.21279 -0.01118 -0.00457 -0.00464 315 ASP A CG  
1939 O OD1 . ASP A 135 ? 0.18934 0.18331 0.20730 -0.01005 -0.00484 -0.00242 315 ASP A OD1 
1940 O OD2 . ASP A 135 ? 0.19095 0.17468 0.20185 -0.01282 -0.00337 -0.00762 315 ASP A OD2 
1945 N N   . ASN A 136 ? 0.17100 0.18715 0.16520 -0.00065 -0.00408 0.00745  316 ASN A N   
1946 C CA  . ASN A 136 ? 0.17791 0.19822 0.16770 0.00277  0.00001  0.01403  316 ASN A CA  
1947 C C   . ASN A 136 ? 0.17025 0.20826 0.14822 0.00670  -0.00261 0.01343  316 ASN A C   
1948 O O   . ASN A 136 ? 0.18859 0.22980 0.15847 0.00523  -0.00334 0.00384  316 ASN A O   
1949 C CB  . ASN A 136 ? 0.17421 0.18795 0.16438 0.00043  0.00298  0.00965  316 ASN A CB  
1950 C CG  . ASN A 136 ? 0.19333 0.21498 0.17866 0.00377  0.00774  0.01496  316 ASN A CG  
1951 O OD1 . ASN A 136 ? 0.22194 0.24991 0.20583 0.00732  0.01081  0.02517  316 ASN A OD1 
1952 N ND2 . ASN A 136 ? 0.19738 0.21948 0.18009 0.00409  0.00967  0.00946  316 ASN A ND2 
1959 N N   . PRO A 137 ? 0.16739 0.21888 0.14373 0.01266  -0.00361 0.02330  317 PRO A N   
1960 C CA  . PRO A 137 ? 0.19249 0.26870 0.15583 0.01709  -0.00761 0.02223  317 PRO A CA  
1961 C C   . PRO A 137 ? 0.22112 0.30577 0.17374 0.02287  -0.00224 0.03049  317 PRO A C   
1962 O O   . PRO A 137 ? 0.26993 0.37505 0.20833 0.02500  -0.00517 0.02444  317 PRO A O   
1963 C CB  . PRO A 137 ? 0.19180 0.28310 0.15916 0.02375  -0.01082 0.03265  317 PRO A CB  
1964 C CG  . PRO A 137 ? 0.20048 0.27067 0.18041 0.02602  -0.00343 0.04520  317 PRO A CG  
1965 C CD  . PRO A 137 ? 0.17944 0.22608 0.16632 0.01619  -0.00162 0.03419  317 PRO A CD  
1973 N N   . ASN A 138 ? 0.21372 0.28467 0.17300 0.02447  0.00635  0.04268  318 ASN A N   
1974 C CA  . ASN A 138 ? 0.25341 0.33376 0.20475 0.03105  0.01378  0.05550  318 ASN A CA  
1975 C C   . ASN A 138 ? 0.26293 0.33084 0.21941 0.02623  0.02123  0.05352  318 ASN A C   
1976 O O   . ASN A 138 ? 0.29128 0.35956 0.24952 0.02926  0.03078  0.06708  318 ASN A O   
1977 C CB  . ASN A 138 ? 0.27545 0.35521 0.23225 0.03931  0.02036  0.07717  318 ASN A CB  
1978 C CG  . ASN A 138 ? 0.50265 0.59606 0.44884 0.04856  0.02907  0.09448  318 ASN A CG  
1979 O OD1 . ASN A 138 ? 0.43553 0.54903 0.36512 0.05121  0.02700  0.08973  318 ASN A OD1 
1980 N ND2 . ASN A 138 ? 0.57399 0.65586 0.52964 0.05397  0.04040  0.11497  318 ASN A ND2 
1987 N N   . GLY A 139 ? 0.23040 0.28911 0.19047 0.01956  0.01814  0.03843  319 GLY A N   
1988 C CA  . GLY A 139 ? 0.21668 0.27284 0.17975 0.01768  0.02427  0.03627  319 GLY A CA  
1989 C C   . GLY A 139 ? 0.19353 0.23797 0.17473 0.01214  0.02998  0.04151  319 GLY A C   
1990 O O   . GLY A 139 ? 0.24015 0.28906 0.22607 0.01163  0.03787  0.04670  319 GLY A O   
1994 N N   . ASP A 140 ? 0.20199 0.23378 0.19414 0.00704  0.02654  0.03843  320 ASP A N   
1995 C CA  . ASP A 140 ? 0.18905 0.21243 0.19841 0.00012  0.03204  0.04051  320 ASP A CA  
1996 C C   . ASP A 140 ? 0.16959 0.19619 0.18595 -0.00448 0.02975  0.03015  320 ASP A C   
1997 O O   . ASP A 140 ? 0.18778 0.21334 0.21891 -0.01172 0.03261  0.02824  320 ASP A O   
1998 C CB  . ASP A 140 ? 0.18977 0.19959 0.20772 -0.00273 0.03177  0.04211  320 ASP A CB  
1999 C CG  . ASP A 140 ? 0.20292 0.20804 0.22010 -0.00484 0.02293  0.03095  320 ASP A CG  
2000 O OD1 . ASP A 140 ? 0.20807 0.21700 0.22066 -0.00523 0.01742  0.02204  320 ASP A OD1 
2001 O OD2 . ASP A 140 ? 0.28875 0.28437 0.31158 -0.00570 0.02346  0.03235  320 ASP A OD2 
2006 N N   . GLY A 141 ? 0.16695 0.19872 0.17384 -0.00015 0.02546  0.02328  321 GLY A N   
2007 C CA  . GLY A 141 ? 0.17697 0.21400 0.18974 -0.00055 0.02426  0.01676  321 GLY A CA  
2008 C C   . GLY A 141 ? 0.17089 0.20051 0.18095 0.00033  0.01757  0.00944  321 GLY A C   
2009 O O   . GLY A 141 ? 0.19238 0.22589 0.20284 0.00441  0.01718  0.00607  321 GLY A O   
2013 N N   . ARG A 142 ? 0.15979 0.17940 0.16803 -0.00226 0.01360  0.00842  322 ARG A N   
2014 C CA  . ARG A 142 ? 0.18010 0.19285 0.18667 -0.00196 0.00894  0.00291  322 ARG A CA  
2015 C C   . ARG A 142 ? 0.16943 0.17670 0.16573 0.00271  0.00875  -0.00164 322 ARG A C   
2016 O O   . ARG A 142 ? 0.20292 0.20949 0.19165 0.00278  0.00824  -0.00346 322 ARG A O   
2017 C CB  . ARG A 142 ? 0.17189 0.17688 0.18051 -0.00598 0.00622  0.00290  322 ARG A CB  
2018 C CG  . ARG A 142 ? 0.19394 0.19963 0.21348 -0.01152 0.00801  0.00367  322 ARG A CG  
2019 C CD  . ARG A 142 ? 0.17996 0.17632 0.20087 -0.01345 0.00681  0.00304  322 ARG A CD  
2020 N NE  . ARG A 142 ? 0.18110 0.17343 0.20300 -0.01181 0.01027  0.01031  322 ARG A NE  
2021 C CZ  . ARG A 142 ? 0.18223 0.16709 0.20828 -0.01168 0.01159  0.01216  322 ARG A CZ  
2022 N NH1 . ARG A 142 ? 0.20391 0.18492 0.23141 -0.01361 0.00904  0.00592  322 ARG A NH1 
2023 N NH2 . ARG A 142 ? 0.17953 0.16136 0.20825 -0.00813 0.01674  0.02177  322 ARG A NH2 
2037 N N   . CYS A 143 ? 0.16765 0.17180 0.16414 0.00667  0.00983  -0.00382 323 CYS A N   
2038 C CA  . CYS A 143 ? 0.17834 0.17165 0.16770 0.01007  0.01252  -0.00931 323 CYS A CA  
2039 C C   . CYS A 143 ? 0.19154 0.17181 0.18151 0.00950  0.01233  -0.01073 323 CYS A C   
2040 O O   . CYS A 143 ? 0.20362 0.17250 0.18969 0.00732  0.01437  -0.01724 323 CYS A O   
2041 C CB  . CYS A 143 ? 0.20631 0.20220 0.19464 0.01796  0.01864  -0.00966 323 CYS A CB  
2042 S SG  . CYS A 143 ? 0.21840 0.22231 0.21567 0.02626  0.02038  -0.00246 323 CYS A SG  
2048 N N   . VAL A 144 ? 0.17999 0.16341 0.17480 0.01049  0.01050  -0.00562 324 VAL A N   
2049 C CA  . VAL A 144 ? 0.17332 0.14613 0.16773 0.01091  0.01160  -0.00438 324 VAL A CA  
2050 C C   . VAL A 144 ? 0.17612 0.15581 0.17342 0.00610  0.00664  -0.00278 324 VAL A C   
2051 O O   . VAL A 144 ? 0.18139 0.17496 0.18237 0.00608  0.00387  -0.00097 324 VAL A O   
2052 C CB  . VAL A 144 ? 0.16108 0.13260 0.15575 0.02127  0.01662  0.00208  324 VAL A CB  
2053 C CG1 . VAL A 144 ? 0.21469 0.17708 0.20820 0.02283  0.01902  0.00691  324 VAL A CG1 
2054 C CG2 . VAL A 144 ? 0.20469 0.16523 0.19753 0.02758  0.02421  0.00005  324 VAL A CG2 
2064 N N   . THR A 145 ? 0.17331 0.14457 0.17020 0.00136  0.00627  -0.00492 325 THR A N   
2065 C CA  . THR A 145 ? 0.15573 0.13118 0.15474 -0.00182 0.00366  -0.00404 325 THR A CA  
2066 C C   . THR A 145 ? 0.15559 0.12760 0.15177 0.00269  0.00712  0.00075  325 THR A C   
2067 O O   . THR A 145 ? 0.20534 0.16396 0.20026 0.00445  0.01270  0.00232  325 THR A O   
2068 C CB  . THR A 145 ? 0.16300 0.13387 0.16413 -0.00765 0.00259  -0.00763 325 THR A CB  
2069 O OG1 . THR A 145 ? 0.18745 0.16325 0.18932 -0.00919 0.00016  -0.00923 325 THR A OG1 
2070 C CG2 . THR A 145 ? 0.19539 0.16965 0.19938 -0.00992 0.00147  -0.00728 325 THR A CG2 
2078 N N   . CYS A 146 ? 0.16973 0.15455 0.16492 0.00439  0.00477  0.00279  326 CYS A N   
2079 C CA  . CYS A 146 ? 0.18427 0.17119 0.17432 0.01058  0.00796  0.00962  326 CYS A CA  
2080 C C   . CYS A 146 ? 0.16878 0.16288 0.15764 0.00601  0.00593  0.00621  326 CYS A C   
2081 O O   . CYS A 146 ? 0.19277 0.19929 0.18378 0.00198  0.00142  -0.00028 326 CYS A O   
2082 C CB  . CYS A 146 ? 0.19999 0.20490 0.18798 0.01938  0.00638  0.01488  326 CYS A CB  
2083 S SG  . CYS A 146 ? 0.22807 0.24260 0.20748 0.03115  0.01014  0.02721  326 CYS A SG  
2089 N N   . ILE A 147 ? 0.18917 0.17488 0.17553 0.00636  0.01086  0.00995  327 ILE A N   
2090 C CA  . ILE A 147 ? 0.18607 0.17725 0.17134 0.00263  0.01078  0.00639  327 ILE A CA  
2091 C C   . ILE A 147 ? 0.17691 0.17294 0.15352 0.00941  0.01605  0.01533  327 ILE A C   
2092 O O   . ILE A 147 ? 0.20923 0.19245 0.18513 0.01340  0.02326  0.02456  327 ILE A O   
2093 C CB  . ILE A 147 ? 0.17709 0.15665 0.16993 -0.00439 0.01264  0.00231  327 ILE A CB  
2094 C CG1 . ILE A 147 ? 0.19459 0.17080 0.19412 -0.00852 0.00827  -0.00304 327 ILE A CG1 
2095 C CG2 . ILE A 147 ? 0.17995 0.16628 0.17324 -0.00688 0.01325  -0.00214 327 ILE A CG2 
2096 C CD1 . ILE A 147 ? 0.21012 0.18291 0.21749 -0.01360 0.00852  -0.00632 327 ILE A CD1 
2108 N N   . TYR A 148 ? 0.17023 0.18403 0.14027 0.01039  0.01389  0.01223  328 TYR A N   
2109 C CA  . TYR A 148 ? 0.18763 0.21088 0.14680 0.01740  0.01904  0.02088  328 TYR A CA  
2110 C C   . TYR A 148 ? 0.19648 0.21892 0.15616 0.01165  0.02207  0.01439  328 TYR A C   
2111 O O   . TYR A 148 ? 0.19968 0.22817 0.16232 0.00570  0.01782  0.00142  328 TYR A O   
2112 C CB  . TYR A 148 ? 0.16890 0.22136 0.11808 0.02405  0.01333  0.02070  328 TYR A CB  
2113 C CG  . TYR A 148 ? 0.20403 0.27275 0.13874 0.03367  0.01790  0.03116  328 TYR A CG  
2114 C CD1 . TYR A 148 ? 0.20394 0.26659 0.13316 0.04605  0.02600  0.05135  328 TYR A CD1 
2115 C CD2 . TYR A 148 ? 0.21369 0.30350 0.13912 0.03171  0.01610  0.02210  328 TYR A CD2 
2116 C CE1 . TYR A 148 ? 0.21641 0.29429 0.13132 0.05663  0.03179  0.06437  328 TYR A CE1 
2117 C CE2 . TYR A 148 ? 0.22588 0.33380 0.13556 0.04155  0.02072  0.03257  328 TYR A CE2 
2118 C CZ  . TYR A 148 ? 0.22805 0.33225 0.13142 0.05518  0.02839  0.05563  328 TYR A CZ  
2119 O OH  . TYR A 148 ? 0.25028 0.37360 0.13677 0.06669  0.03433  0.06911  328 TYR A OH  
2129 N N   . TYR A 149 ? 0.20287 0.21733 0.16086 0.01373  0.03107  0.02367  329 TYR A N   
2130 C CA  . TYR A 149 ? 0.19432 0.21046 0.15351 0.00968  0.03561  0.01907  329 TYR A CA  
2131 C C   . TYR A 149 ? 0.21636 0.25125 0.15950 0.01727  0.04003  0.02486  329 TYR A C   
2132 O O   . TYR A 149 ? 0.24709 0.28788 0.17995 0.02676  0.04347  0.03900  329 TYR A O   
2133 C CB  . TYR A 149 ? 0.21476 0.21255 0.18580 0.00488  0.04358  0.02436  329 TYR A CB  
2134 C CG  . TYR A 149 ? 0.20128 0.18657 0.18651 -0.00255 0.03857  0.01719  329 TYR A CG  
2135 C CD1 . TYR A 149 ? 0.18373 0.17225 0.17721 -0.00760 0.03339  0.00634  329 TYR A CD1 
2136 C CD2 . TYR A 149 ? 0.22034 0.19120 0.20998 -0.00333 0.04029  0.02179  329 TYR A CD2 
2137 C CE1 . TYR A 149 ? 0.21615 0.19785 0.22059 -0.01252 0.02890  0.00193  329 TYR A CE1 
2138 C CE2 . TYR A 149 ? 0.20754 0.17117 0.20776 -0.00995 0.03567  0.01419  329 TYR A CE2 
2139 C CZ  . TYR A 149 ? 0.22430 0.19540 0.23096 -0.01405 0.02932  0.00518  329 TYR A CZ  
2140 O OH  . TYR A 149 ? 0.23232 0.20021 0.24724 -0.01873 0.02475  -0.00017 329 TYR A OH  
2150 N N   . LEU A 150 ? 0.21912 0.26415 0.15960 0.01436  0.04108  0.01449  330 LEU A N   
2151 C CA  . LEU A 150 ? 0.23339 0.30222 0.15572 0.02111  0.04364  0.01550  330 LEU A CA  
2152 C C   . LEU A 150 ? 0.21799 0.28881 0.13915 0.01977  0.05279  0.01278  330 LEU A C   
2153 O O   . LEU A 150 ? 0.27079 0.36250 0.17801 0.02249  0.05361  0.00486  330 LEU A O   
2154 C CB  . LEU A 150 ? 0.27296 0.36419 0.18738 0.02010  0.03357  0.00007  330 LEU A CB  
2155 C CG  . LEU A 150 ? 0.22538 0.30651 0.15308 0.00941  0.02999  -0.01975 330 LEU A CG  
2156 C CD1 . LEU A 150 ? 0.26516 0.36817 0.18261 0.00721  0.02840  -0.03766 330 LEU A CD1 
2157 C CD2 . LEU A 150 ? 0.23910 0.31205 0.17783 0.00500  0.02159  -0.02297 330 LEU A CD2 
2169 N N   . ASN A 151 ? 0.23919 0.29202 0.17435 0.01588  0.06047  0.01917  331 ASN A N   
2170 C CA  . ASN A 151 ? 0.23641 0.29168 0.17580 0.01386  0.06942  0.01590  331 ASN A CA  
2171 C C   . ASN A 151 ? 0.24356 0.30327 0.17419 0.01976  0.08240  0.03388  331 ASN A C   
2172 O O   . ASN A 151 ? 0.29057 0.33488 0.23388 0.01651  0.09067  0.04564  331 ASN A O   
2173 C CB  . ASN A 151 ? 0.20573 0.24453 0.16881 0.00553  0.06877  0.01092  331 ASN A CB  
2174 C CG  . ASN A 151 ? 0.19876 0.23229 0.16861 0.00193  0.05783  -0.00206 331 ASN A CG  
2175 O OD1 . ASN A 151 ? 0.23043 0.27059 0.19696 0.00209  0.05592  -0.01540 331 ASN A OD1 
2176 N ND2 . ASN A 151 ? 0.20296 0.22437 0.18115 -0.00118 0.05200  0.00123  331 ASN A ND2 
2183 N N   . LYS A 152 ? 0.26831 0.35060 0.17712 0.02800  0.08505  0.03538  332 LYS A N   
2184 C CA  . LYS A 152 ? 0.27733 0.36709 0.17487 0.03549  0.09891  0.05392  332 LYS A CA  
2185 C C   . LYS A 152 ? 0.38572 0.47089 0.29767 0.02918  0.10940  0.05000  332 LYS A C   
2186 O O   . LYS A 152 ? 0.57850 0.66793 0.49654 0.02491  0.10554  0.03146  332 LYS A O   
2187 C CB  . LYS A 152 ? 0.31337 0.43115 0.18654 0.04389  0.09447  0.05030  332 LYS A CB  
2188 C CG  . LYS A 152 ? 0.36292 0.48460 0.22665 0.05304  0.10048  0.07113  332 LYS A CG  
2193 N N   . ASP A 153 ? 0.56202 0.63665 0.48339 0.02766  0.12213  0.06605  333 ASP A N   
2194 C CA  . ASP A 153 ? 0.36501 0.43956 0.30304 0.02115  0.13207  0.06318  333 ASP A CA  
2195 C C   . ASP A 153 ? 0.28370 0.34555 0.25050 0.00992  0.12908  0.05338  333 ASP A C   
2196 O O   . ASP A 153 ? 0.31391 0.38129 0.29668 0.00540  0.13769  0.05141  333 ASP A O   
2197 C CB  . ASP A 153 ? 0.39911 0.49494 0.32575 0.02502  0.13415  0.05104  333 ASP A CB  
2198 C CG  . ASP A 153 ? 0.67730 0.78952 0.57556 0.03417  0.13053  0.05283  333 ASP A CG  
2199 O OD1 . ASP A 153 ? 0.77626 0.90326 0.66150 0.03638  0.12434  0.03530  333 ASP A OD1 
2200 O OD2 . ASP A 153 ? 0.56484 0.67468 0.45573 0.03904  0.13404  0.07104  333 ASP A OD2 
2205 N N   . TRP A 154 ? 0.25846 0.30677 0.23339 0.00547  0.11662  0.04728  334 TRP A N   
2206 C CA  . TRP A 154 ? 0.22930 0.26980 0.23021 -0.00449 0.11173  0.03831  334 TRP A CA  
2207 C C   . TRP A 154 ? 0.25653 0.29031 0.27769 -0.01348 0.12345  0.04759  334 TRP A C   
2208 O O   . TRP A 154 ? 0.28285 0.30201 0.30247 -0.01505 0.13020  0.05989  334 TRP A O   
2209 C CB  . TRP A 154 ? 0.24275 0.27064 0.24504 -0.00671 0.09761  0.03258  334 TRP A CB  
2210 C CG  . TRP A 154 ? 0.21491 0.24178 0.23793 -0.01356 0.08977  0.02144  334 TRP A CG  
2211 C CD1 . TRP A 154 ? 0.21795 0.23858 0.26029 -0.02267 0.08860  0.02117  334 TRP A CD1 
2212 C CD2 . TRP A 154 ? 0.20688 0.24134 0.23321 -0.01088 0.08307  0.00925  334 TRP A CD2 
2213 N NE1 . TRP A 154 ? 0.21584 0.24404 0.27167 -0.02443 0.07989  0.01104  334 TRP A NE1 
2214 C CE2 . TRP A 154 ? 0.22942 0.26373 0.27628 -0.01647 0.07740  0.00515  334 TRP A CE2 
2215 C CE3 . TRP A 154 ? 0.21050 0.25179 0.22455 -0.00422 0.08242  0.00076  334 TRP A CE3 
2216 C CZ2 . TRP A 154 ? 0.19648 0.23617 0.25180 -0.01317 0.07180  -0.00318 334 TRP A CZ2 
2217 C CZ3 . TRP A 154 ? 0.22296 0.26466 0.24716 -0.00288 0.07816  -0.00980 334 TRP A CZ3 
2218 C CH2 . TRP A 154 ? 0.22115 0.26167 0.26572 -0.00613 0.07338  -0.00970 334 TRP A CH2 
2229 N N   . ASP A 155 ? 0.24616 0.29090 0.28843 -0.01957 0.12660  0.04114  335 ASP A N   
2230 C CA  . ASP A 155 ? 0.27779 0.32162 0.34543 -0.03164 0.13553  0.04469  335 ASP A CA  
2231 C C   . ASP A 155 ? 0.25304 0.30290 0.34230 -0.03907 0.12335  0.03133  335 ASP A C   
2232 O O   . ASP A 155 ? 0.23889 0.30753 0.33989 -0.03711 0.12069  0.02395  335 ASP A O   
2233 C CB  . ASP A 155 ? 0.24877 0.30823 0.32072 -0.03085 0.14546  0.04834  335 ASP A CB  
2234 C CG  . ASP A 155 ? 0.25217 0.31313 0.34869 -0.04372 0.14923  0.04874  335 ASP A CG  
2235 O OD1 . ASP A 155 ? 0.28887 0.33783 0.39721 -0.05322 0.14376  0.04490  335 ASP A OD1 
2236 O OD2 . ASP A 155 ? 0.25330 0.32836 0.35670 -0.04466 0.15755  0.05148  335 ASP A OD2 
2241 N N   . ALA A 156 ? 0.23989 0.27530 0.33334 -0.04584 0.11594  0.02857  336 ALA A N   
2242 C CA  . ALA A 156 ? 0.23502 0.27888 0.34314 -0.05051 0.10229  0.01644  336 ALA A CA  
2243 C C   . ALA A 156 ? 0.23883 0.30572 0.37605 -0.06029 0.10548  0.01115  336 ALA A C   
2244 O O   . ALA A 156 ? 0.22380 0.30881 0.37308 -0.05959 0.09474  0.00295  336 ALA A O   
2245 C CB  . ALA A 156 ? 0.28587 0.31140 0.39166 -0.05629 0.09559  0.01372  336 ALA A CB  
2251 N N   . LYS A 157 ? 0.20555 0.27223 0.34884 -0.06658 0.11467  0.01611  337 LYS A N   
2252 C CA  . LYS A 157 ? 0.19364 0.28498 0.36115 -0.07486 0.11358  0.01039  337 LYS A CA  
2253 C C   . LYS A 157 ? 0.25097 0.36930 0.42629 -0.06561 0.11422  0.00963  337 LYS A C   
2254 O O   . LYS A 157 ? 0.31393 0.45929 0.50998 -0.06819 0.10864  0.00396  337 LYS A O   
2255 C CB  . LYS A 157 ? 0.24136 0.32617 0.41461 -0.08384 0.12509  0.01608  337 LYS A CB  
2256 C CG  . LYS A 157 ? 0.40337 0.47051 0.58222 -0.09628 0.12343  0.01087  337 LYS A CG  
2257 C CD  . LYS A 157 ? 0.47274 0.56447 0.67473 -0.10767 0.11390  -0.00263 337 LYS A CD  
2264 N N   A VAL A 158 ? 0.22876 0.34140 0.38694 -0.05362 0.12091  0.01493  338 VAL A N   
2265 N N   B VAL A 158 ? 0.22837 0.34118 0.38665 -0.05359 0.12091  0.01491  338 VAL A N   
2266 C CA  A VAL A 158 ? 0.25820 0.39082 0.42041 -0.04237 0.12322  0.01287  338 VAL A CA  
2267 C CA  B VAL A 158 ? 0.25701 0.39016 0.41981 -0.04249 0.12310  0.01276  338 VAL A CA  
2268 C C   A VAL A 158 ? 0.24416 0.37216 0.39771 -0.03159 0.11276  0.00685  338 VAL A C   
2269 C C   B VAL A 158 ? 0.24384 0.37189 0.39709 -0.03131 0.11303  0.00691  338 VAL A C   
2270 O O   A VAL A 158 ? 0.26045 0.40563 0.42726 -0.02464 0.10808  0.00271  338 VAL A O   
2271 O O   B VAL A 158 ? 0.25884 0.40375 0.42456 -0.02378 0.10901  0.00287  338 VAL A O   
2272 C CB  A VAL A 158 ? 0.22446 0.35362 0.36883 -0.03522 0.13626  0.01990  338 VAL A CB  
2273 C CB  B VAL A 158 ? 0.22800 0.35935 0.37479 -0.03579 0.13637  0.01976  338 VAL A CB  
2278 N N   . SER A 159 ? 0.20567 0.30932 0.33434 -0.02862 0.10726  0.00735  339 SER A N   
2279 C CA  . SER A 159 ? 0.22631 0.32111 0.34110 -0.01831 0.09756  0.00167  339 SER A CA  
2280 C C   . SER A 159 ? 0.20681 0.29561 0.32490 -0.02091 0.08336  -0.00163 339 SER A C   
2281 O O   . SER A 159 ? 0.21223 0.29387 0.32254 -0.01309 0.07645  -0.00534 339 SER A O   
2282 C CB  . SER A 159 ? 0.23224 0.31065 0.31849 -0.01320 0.10001  0.00262  339 SER A CB  
2283 O OG  . SER A 159 ? 0.25400 0.34188 0.33467 -0.00852 0.11290  0.00441  339 SER A OG  
2289 N N   . GLY A 160 ? 0.19955 0.29063 0.32883 -0.03202 0.08011  -0.00117 340 GLY A N   
2290 C CA  . GLY A 160 ? 0.19536 0.28548 0.32746 -0.03424 0.06700  -0.00528 340 GLY A CA  
2291 C C   . GLY A 160 ? 0.21704 0.28223 0.32653 -0.03177 0.06123  -0.00502 340 GLY A C   
2292 O O   . GLY A 160 ? 0.20622 0.25537 0.30167 -0.03361 0.06644  -0.00113 340 GLY A O   
2296 N N   . GLY A 161 ? 0.15881 0.22274 0.26557 -0.02671 0.05095  -0.00775 341 GLY A N   
2297 C CA  . GLY A 161 ? 0.15292 0.19659 0.24051 -0.02414 0.04581  -0.00796 341 GLY A CA  
2298 C C   . GLY A 161 ? 0.19084 0.22288 0.27322 -0.03184 0.04291  -0.00780 341 GLY A C   
2299 O O   . GLY A 161 ? 0.18331 0.20007 0.24979 -0.02910 0.04082  -0.00647 341 GLY A O   
2303 N N   . ILE A 162 ? 0.16995 0.20993 0.26624 -0.04135 0.04311  -0.01041 342 ILE A N   
2304 C CA  . ILE A 162 ? 0.18488 0.21078 0.27712 -0.04866 0.04196  -0.01259 342 ILE A CA  
2305 C C   . ILE A 162 ? 0.21258 0.23787 0.29792 -0.04497 0.03065  -0.01604 342 ILE A C   
2306 O O   . ILE A 162 ? 0.17823 0.22125 0.27061 -0.04173 0.02348  -0.01813 342 ILE A O   
2307 C CB  . ILE A 162 ? 0.19770 0.23345 0.30903 -0.06214 0.04620  -0.01837 342 ILE A CB  
2308 C CG1 . ILE A 162 ? 0.18447 0.21496 0.30138 -0.06640 0.06076  -0.01241 342 ILE A CG1 
2309 C CG2 . ILE A 162 ? 0.24344 0.26508 0.35283 -0.07049 0.04491  -0.02486 342 ILE A CG2 
2310 C CD1 . ILE A 162 ? 0.24359 0.28504 0.38224 -0.08084 0.06685  -0.01834 342 ILE A CD1 
2322 N N   . LEU A 163 ? 0.12182 0.26569 0.23376 -0.00558 0.00637  0.03875  343 LEU A N   
2323 C CA  . LEU A 163 ? 0.13433 0.23804 0.23935 0.00331  0.00915  0.03867  343 LEU A CA  
2324 C C   . LEU A 163 ? 0.14363 0.22516 0.24349 -0.00153 0.00971  0.04145  343 LEU A C   
2325 O O   . LEU A 163 ? 0.16799 0.24385 0.27543 -0.00908 0.01107  0.05262  343 LEU A O   
2326 C CB  . LEU A 163 ? 0.14133 0.23658 0.25508 0.00610  0.01415  0.04462  343 LEU A CB  
2327 C CG  . LEU A 163 ? 0.14909 0.20888 0.25828 0.00903  0.02279  0.03932  343 LEU A CG  
2328 C CD1 . LEU A 163 ? 0.17962 0.22227 0.27151 0.01269  0.02731  0.03005  343 LEU A CD1 
2329 C CD2 . LEU A 163 ? 0.15141 0.20990 0.28119 0.01096  0.02673  0.03781  343 LEU A CD2 
2341 N N   . ARG A 164 ? 0.14657 0.21584 0.23417 0.00349  0.00553  0.03049  344 ARG A N   
2342 C CA  . ARG A 164 ? 0.17028 0.22240 0.25428 0.00047  0.00542  0.02739  344 ARG A CA  
2343 C C   . ARG A 164 ? 0.14392 0.16114 0.21112 0.00460  0.01223  0.02665  344 ARG A C   
2344 O O   . ARG A 164 ? 0.17578 0.17445 0.21771 0.01096  0.01183  0.02317  344 ARG A O   
2345 C CB  . ARG A 164 ? 0.15385 0.21927 0.23531 0.00388  -0.00564 0.01097  344 ARG A CB  
2346 C CG  . ARG A 164 ? 0.17597 0.22682 0.25522 0.00222  -0.00677 0.00286  344 ARG A CG  
2347 C CD  . ARG A 164 ? 0.18108 0.25737 0.27024 0.00466  -0.01902 -0.01873 344 ARG A CD  
2348 N NE  . ARG A 164 ? 0.15723 0.26784 0.27609 -0.01310 -0.01148 -0.02004 344 ARG A NE  
2349 C CZ  . ARG A 164 ? 0.18630 0.33155 0.32677 -0.01889 -0.01558 -0.04335 344 ARG A CZ  
2350 N NH1 . ARG A 164 ? 0.19880 0.35163 0.33901 -0.00241 -0.03321 -0.06938 344 ARG A NH1 
2351 N NH2 . ARG A 164 ? 0.21252 0.38396 0.37392 -0.04298 -0.00209 -0.04202 344 ARG A NH2 
2365 N N   . ILE A 165 ? 0.16599 0.17282 0.24700 -0.00079 0.01890  0.02858  345 ILE A N   
2366 C CA  . ILE A 165 ? 0.18304 0.16629 0.25464 -0.00100 0.02893  0.02049  345 ILE A CA  
2367 C C   . ILE A 165 ? 0.17783 0.15385 0.24509 -0.00294 0.02658  0.00971  345 ILE A C   
2368 O O   . ILE A 165 ? 0.18541 0.17195 0.27616 -0.00675 0.02082  0.00996  345 ILE A O   
2369 C CB  . ILE A 165 ? 0.17445 0.15823 0.27684 -0.00288 0.03536  0.02080  345 ILE A CB  
2370 C CG1 . ILE A 165 ? 0.17011 0.16910 0.28253 0.00056  0.03358  0.02955  345 ILE A CG1 
2371 C CG2 . ILE A 165 ? 0.20360 0.17263 0.30153 -0.00628 0.05064  0.00379  345 ILE A CG2 
2372 C CD1 . ILE A 165 ? 0.17380 0.17611 0.31937 0.00351  0.03127  0.02887  345 ILE A CD1 
2384 N N   . PHE A 166 ? 0.21642 0.17345 0.25151 -0.00269 0.03229  -0.00043 346 PHE A N   
2385 C CA  . PHE A 166 ? 0.22170 0.17470 0.24727 -0.00344 0.02965  -0.01498 346 PHE A CA  
2386 C C   . PHE A 166 ? 0.24174 0.18761 0.27486 -0.01123 0.04576  -0.02903 346 PHE A C   
2387 O O   . PHE A 166 ? 0.26840 0.19902 0.26043 -0.01569 0.05509  -0.03785 346 PHE A O   
2388 C CB  . PHE A 166 ? 0.26866 0.20548 0.24029 0.00393  0.01929  -0.01726 346 PHE A CB  
2389 C CG  . PHE A 166 ? 0.24787 0.19606 0.21967 0.01441  0.00067  -0.01207 346 PHE A CG  
2390 C CD1 . PHE A 166 ? 0.25260 0.22571 0.24787 0.01816  -0.01304 -0.02401 346 PHE A CD1 
2391 C CD2 . PHE A 166 ? 0.26287 0.20047 0.21717 0.01948  -0.00254 -0.00120 346 PHE A CD2 
2392 C CE1 . PHE A 166 ? 0.24751 0.23995 0.25121 0.02630  -0.02856 -0.02794 346 PHE A CE1 
2393 C CE2 . PHE A 166 ? 0.30607 0.25951 0.26780 0.03035  -0.02117 -0.00377 346 PHE A CE2 
2394 C CZ  . PHE A 166 ? 0.26086 0.24405 0.24770 0.03380  -0.03407 -0.01895 346 PHE A CZ  
2404 N N   . PRO A 167 ? 0.21930 0.17468 0.30263 -0.01375 0.04857  -0.03373 347 PRO A N   
2405 C CA  . PRO A 167 ? 0.22700 0.18247 0.32873 -0.01969 0.06295  -0.05564 347 PRO A CA  
2406 C C   . PRO A 167 ? 0.25384 0.20965 0.33646 -0.02398 0.06667  -0.07716 347 PRO A C   
2407 O O   . PRO A 167 ? 0.26892 0.23063 0.36414 -0.02071 0.05465  -0.08175 347 PRO A O   
2408 C CB  . PRO A 167 ? 0.20731 0.16849 0.37094 -0.01590 0.05440  -0.05577 347 PRO A CB  
2409 C CG  . PRO A 167 ? 0.23450 0.19501 0.40182 -0.01388 0.03866  -0.03540 347 PRO A CG  
2410 C CD  . PRO A 167 ? 0.21844 0.18219 0.34195 -0.01214 0.03726  -0.02104 347 PRO A CD  
2418 N N   . GLU A 168 ? 0.28307 0.23484 0.33516 -0.03376 0.08519  -0.09323 348 GLU A N   
2419 C CA  . GLU A 168 ? 0.31795 0.27217 0.34121 -0.03996 0.09068  -0.11554 348 GLU A CA  
2420 C C   . GLU A 168 ? 0.37053 0.34586 0.45822 -0.03830 0.08666  -0.14174 348 GLU A C   
2421 O O   . GLU A 168 ? 0.30912 0.29329 0.45837 -0.03739 0.08866  -0.15203 348 GLU A O   
2422 C CB  . GLU A 168 ? 0.40306 0.35124 0.38479 -0.05756 0.11768  -0.13022 348 GLU A CB  
2423 C CG  . GLU A 168 ? 0.61155 0.55572 0.53254 -0.06722 0.12459  -0.14698 348 GLU A CG  
2430 N N   . GLY A 169 ? 0.33194 0.31345 0.40766 -0.03572 0.07714  -0.15361 349 GLY A N   
2431 C CA  . GLY A 169 ? 0.35648 0.35680 0.48944 -0.03578 0.07427  -0.18353 349 GLY A CA  
2432 C C   . GLY A 169 ? 0.40321 0.40110 0.59694 -0.02868 0.05702  -0.17287 349 GLY A C   
2433 O O   . GLY A 169 ? 0.40361 0.41006 0.65217 -0.02923 0.05337  -0.19677 349 GLY A O   
2437 N N   . LYS A 170 ? 0.28880 0.27441 0.47399 -0.02441 0.04740  -0.13952 350 LYS A N   
2438 C CA  . LYS A 170 ? 0.27234 0.25090 0.50523 -0.02387 0.03519  -0.12491 350 LYS A CA  
2439 C C   . LYS A 170 ? 0.26342 0.25040 0.48407 -0.02453 0.02568  -0.12234 350 LYS A C   
2440 O O   . LYS A 170 ? 0.27838 0.27187 0.45015 -0.01970 0.02228  -0.11824 350 LYS A O   
2441 C CB  . LYS A 170 ? 0.23147 0.19697 0.46435 -0.02181 0.03283  -0.09306 350 LYS A CB  
2442 C CG  . LYS A 170 ? 0.27112 0.23289 0.52732 -0.01893 0.03888  -0.10012 350 LYS A CG  
2443 C CD  . LYS A 170 ? 0.42013 0.36788 0.74099 -0.01592 0.02645  -0.10505 350 LYS A CD  
2444 C CE  . LYS A 170 ? 0.34377 0.28732 0.68924 -0.00719 0.02064  -0.09989 350 LYS A CE  
2445 N NZ  . LYS A 170 ? 0.30010 0.24543 0.69455 -0.00022 0.00537  -0.10928 350 LYS A NZ  
2459 N N   . ALA A 171 ? 0.24693 0.23163 0.51550 -0.03078 0.02024  -0.12629 351 ALA A N   
2460 C CA  . ALA A 171 ? 0.24434 0.24248 0.51671 -0.03558 0.01426  -0.13054 351 ALA A CA  
2461 C C   . ALA A 171 ? 0.23211 0.22921 0.49043 -0.04038 0.01231  -0.10104 351 ALA A C   
2462 O O   . ALA A 171 ? 0.23927 0.25116 0.51012 -0.04873 0.01031  -0.10664 351 ALA A O   
2463 C CB  . ALA A 171 ? 0.25489 0.24795 0.58700 -0.04628 0.01351  -0.14711 351 ALA A CB  
2469 N N   . GLN A 172 ? 0.24163 0.22636 0.48046 -0.03741 0.01417  -0.07445 352 GLN A N   
2470 C CA  . GLN A 172 ? 0.21377 0.20386 0.43893 -0.04271 0.01307  -0.05052 352 GLN A CA  
2471 C C   . GLN A 172 ? 0.28087 0.26879 0.47053 -0.03194 0.01386  -0.03523 352 GLN A C   
2472 O O   . GLN A 172 ? 0.34965 0.32576 0.53519 -0.02559 0.01793  -0.03796 352 GLN A O   
2473 C CB  . GLN A 172 ? 0.26090 0.23128 0.51321 -0.05823 0.01430  -0.02846 352 GLN A CB  
2476 N N   . PHE A 173 ? 0.22079 0.22326 0.38980 -0.03127 0.01135  -0.02423 353 PHE A N   
2477 C CA  . PHE A 173 ? 0.21243 0.21133 0.35706 -0.02370 0.01268  -0.00819 353 PHE A CA  
2478 C C   . PHE A 173 ? 0.21031 0.20526 0.37020 -0.03182 0.01367  0.01510  353 PHE A C   
2479 O O   . PHE A 173 ? 0.26104 0.25089 0.44074 -0.04501 0.01339  0.02241  353 PHE A O   
2480 C CB  . PHE A 173 ? 0.34496 0.35785 0.45761 -0.01434 0.00633  -0.01255 353 PHE A CB  
2481 C CG  . PHE A 173 ? 0.25324 0.29337 0.37646 -0.01781 -0.00104 -0.02413 353 PHE A CG  
2482 C CD1 . PHE A 173 ? 0.29386 0.35365 0.43391 -0.03054 0.00283  -0.01439 353 PHE A CD1 
2483 C CD2 . PHE A 173 ? 0.33036 0.37954 0.44429 -0.00830 -0.01247 -0.04785 353 PHE A CD2 
2484 C CE1 . PHE A 173 ? 0.21889 0.31183 0.37425 -0.03770 0.00010  -0.03192 353 PHE A CE1 
2485 C CE2 . PHE A 173 ? 0.25497 0.33685 0.38800 -0.01014 -0.02048 -0.06687 353 PHE A CE2 
2486 C CZ  . PHE A 173 ? 0.29473 0.40137 0.45193 -0.02651 -0.01200 -0.06089 353 PHE A CZ  
2496 N N   . ALA A 174 ? 0.18851 0.20724 0.29728 -0.03353 -0.01648 0.02019  354 ALA A N   
2497 C CA  . ALA A 174 ? 0.17699 0.18285 0.27572 -0.03394 -0.00826 0.02427  354 ALA A CA  
2498 C C   . ALA A 174 ? 0.17490 0.20038 0.28260 -0.02726 0.00030  0.02635  354 ALA A C   
2499 O O   . ALA A 174 ? 0.20723 0.23455 0.31286 -0.01541 0.00034  0.02418  354 ALA A O   
2500 C CB  . ALA A 174 ? 0.21252 0.19565 0.29223 -0.02505 -0.00978 0.02247  354 ALA A CB  
2506 N N   . ASP A 175 ? 0.19864 0.23730 0.31416 -0.03497 0.00763  0.03033  355 ASP A N   
2507 C CA  . ASP A 175 ? 0.18111 0.23885 0.30316 -0.02737 0.01667  0.03138  355 ASP A CA  
2508 C C   . ASP A 175 ? 0.19593 0.23577 0.30038 -0.02537 0.02341  0.03423  355 ASP A C   
2509 O O   . ASP A 175 ? 0.23284 0.26319 0.32991 -0.03569 0.02671  0.03916  355 ASP A O   
2510 C CB  . ASP A 175 ? 0.17869 0.26917 0.32088 -0.03621 0.02178  0.03356  355 ASP A CB  
2511 C CG  . ASP A 175 ? 0.18478 0.30221 0.34697 -0.03348 0.01469  0.02953  355 ASP A CG  
2512 O OD1 . ASP A 175 ? 0.18750 0.29799 0.34549 -0.01959 0.00873  0.02582  355 ASP A OD1 
2513 O OD2 . ASP A 175 ? 0.22610 0.37125 0.40655 -0.04564 0.01486  0.03037  355 ASP A OD2 
2518 N N   . ILE A 176 ? 0.17329 0.20730 0.26918 -0.01302 0.02492  0.03136  356 ILE A N   
2519 C CA  . ILE A 176 ? 0.17104 0.19098 0.24994 -0.00987 0.02963  0.03246  356 ILE A CA  
2520 C C   . ILE A 176 ? 0.15542 0.19081 0.23671 -0.00336 0.03851  0.03168  356 ILE A C   
2521 O O   . ILE A 176 ? 0.16588 0.20289 0.24699 0.00729  0.03807  0.02693  356 ILE A O   
2522 C CB  . ILE A 176 ? 0.19233 0.19522 0.25843 -0.00306 0.02419  0.02851  356 ILE A CB  
2523 C CG1 . ILE A 176 ? 0.21321 0.20643 0.27890 -0.00580 0.01551  0.02735  356 ILE A CG1 
2524 C CG2 . ILE A 176 ? 0.24989 0.24177 0.29929 -0.00162 0.02718  0.02954  356 ILE A CG2 
2525 C CD1 . ILE A 176 ? 0.24602 0.22744 0.30575 -0.01269 0.01356  0.03052  356 ILE A CD1 
2537 N N   . GLU A 177 ? 0.16970 0.21392 0.25040 -0.00925 0.04660  0.03625  357 GLU A N   
2538 C CA  . GLU A 177 ? 0.16000 0.21791 0.23863 -0.00160 0.05602  0.03481  357 GLU A CA  
2539 C C   . GLU A 177 ? 0.18637 0.22321 0.24356 0.00569  0.05534  0.03162  357 GLU A C   
2540 O O   . GLU A 177 ? 0.19258 0.21129 0.23717 0.00168  0.05104  0.03371  357 GLU A O   
2541 C CB  . GLU A 177 ? 0.20583 0.27934 0.28656 -0.01158 0.06592  0.04144  357 GLU A CB  
2542 C CG  . GLU A 177 ? 0.17581 0.27632 0.28062 -0.02197 0.06648  0.04381  357 GLU A CG  
2543 C CD  . GLU A 177 ? 0.25668 0.37901 0.36672 -0.03543 0.07752  0.05073  357 GLU A CD  
2544 O OE1 . GLU A 177 ? 0.27237 0.38909 0.36594 -0.03592 0.08611  0.05469  357 GLU A OE1 
2545 O OE2 . GLU A 177 ? 0.35392 0.50141 0.48487 -0.04702 0.07748  0.05232  357 GLU A OE2 
2552 N N   . PRO A 178 ? 0.17949 0.21855 0.23126 0.01687  0.05889  0.02587  358 PRO A N   
2553 C CA  . PRO A 178 ? 0.18740 0.20648 0.21862 0.02167  0.05676  0.02116  358 PRO A CA  
2554 C C   . PRO A 178 ? 0.20055 0.21892 0.21614 0.02023  0.06309  0.02353  358 PRO A C   
2555 O O   . PRO A 178 ? 0.20458 0.22147 0.20713 0.02756  0.06759  0.01848  358 PRO A O   
2556 C CB  . PRO A 178 ? 0.20159 0.21901 0.23110 0.03371  0.05754  0.01373  358 PRO A CB  
2557 C CG  . PRO A 178 ? 0.19443 0.23880 0.23959 0.03910  0.06524  0.01488  358 PRO A CG  
2558 C CD  . PRO A 178 ? 0.19286 0.25160 0.25662 0.02698  0.06321  0.02203  358 PRO A CD  
2566 N N   . LYS A 179 ? 0.20838 0.22449 0.22189 0.01128  0.06289  0.03119  359 LYS A N   
2567 C CA  . LYS A 179 ? 0.24167 0.25728 0.23980 0.00853  0.06942  0.03672  359 LYS A CA  
2568 C C   . LYS A 179 ? 0.24326 0.24502 0.21909 0.01392  0.06578  0.03289  359 LYS A C   
2569 O O   . LYS A 179 ? 0.22103 0.21193 0.19350 0.01497  0.05652  0.02924  359 LYS A O   
2570 C CB  . LYS A 179 ? 0.25548 0.26411 0.25452 -0.00274 0.06788  0.04640  359 LYS A CB  
2571 C CG  . LYS A 179 ? 0.33809 0.33815 0.31660 -0.00679 0.07288  0.05464  359 LYS A CG  
2572 C CD  . LYS A 179 ? 0.40007 0.38397 0.37462 -0.01833 0.07037  0.06446  359 LYS A CD  
2573 C CE  . LYS A 179 ? 0.35863 0.32814 0.30608 -0.02083 0.07514  0.07389  359 LYS A CE  
2582 N N   . PHE A 180 ? 0.25812 0.26347 0.21834 0.01675  0.07313  0.03364  360 PHE A N   
2583 C CA  . PHE A 180 ? 0.26993 0.26506 0.20771 0.02133  0.06910  0.02975  360 PHE A CA  
2584 C C   . PHE A 180 ? 0.26216 0.24514 0.19208 0.01901  0.05966  0.03434  360 PHE A C   
2585 O O   . PHE A 180 ? 0.28005 0.25698 0.20696 0.01459  0.06064  0.04411  360 PHE A O   
2586 C CB  . PHE A 180 ? 0.31161 0.31294 0.23187 0.02355  0.07928  0.03280  360 PHE A CB  
2587 C CG  . PHE A 180 ? 0.29120 0.28387 0.18571 0.02822  0.07492  0.02944  360 PHE A CG  
2588 C CD1 . PHE A 180 ? 0.31668 0.30670 0.20264 0.03389  0.07144  0.01708  360 PHE A CD1 
2589 C CD2 . PHE A 180 ? 0.32690 0.31228 0.20333 0.02688  0.07341  0.03844  360 PHE A CD2 
2590 C CE1 . PHE A 180 ? 0.38343 0.36850 0.24586 0.03681  0.06616  0.01274  360 PHE A CE1 
2591 C CE2 . PHE A 180 ? 0.35891 0.33972 0.21111 0.03260  0.06803  0.03500  360 PHE A CE2 
2592 C CZ  . PHE A 180 ? 0.37049 0.35363 0.21698 0.03689  0.06425  0.02177  360 PHE A CZ  
2602 N N   . ASP A 181 ? 0.24844 0.22780 0.17347 0.02216  0.05051  0.02698  361 ASP A N   
2603 C CA  . ASP A 181 ? 0.24822 0.22222 0.16497 0.02396  0.04096  0.02927  361 ASP A CA  
2604 C C   . ASP A 181 ? 0.25157 0.22065 0.18233 0.02157  0.03611  0.03313  361 ASP A C   
2605 O O   . ASP A 181 ? 0.28126 0.24299 0.20368 0.02514  0.03003  0.03730  361 ASP A O   
2606 C CB  . ASP A 181 ? 0.27642 0.24474 0.16981 0.02754  0.04259  0.03671  361 ASP A CB  
2607 C CG  . ASP A 181 ? 0.27321 0.24056 0.15338 0.03448  0.03141  0.03550  361 ASP A CG  
2608 O OD1 . ASP A 181 ? 0.28171 0.25931 0.16920 0.03542  0.02366  0.02642  361 ASP A OD1 
2609 O OD2 . ASP A 181 ? 0.30097 0.25820 0.16207 0.03909  0.03043  0.04404  361 ASP A OD2 
2614 N N   . ARG A 182 ? 0.23332 0.20537 0.18326 0.01728  0.03800  0.03125  362 ARG A N   
2615 C CA  . ARG A 182 ? 0.22187 0.18954 0.18436 0.01488  0.03299  0.03325  362 ARG A CA  
2616 C C   . ARG A 182 ? 0.21102 0.18400 0.17991 0.01646  0.02574  0.02542  362 ARG A C   
2617 O O   . ARG A 182 ? 0.21217 0.18999 0.18510 0.01495  0.02679  0.01913  362 ARG A O   
2618 C CB  . ARG A 182 ? 0.23605 0.20731 0.21544 0.00894  0.03843  0.03564  362 ARG A CB  
2619 C CG  . ARG A 182 ? 0.22606 0.19431 0.21874 0.00641  0.03237  0.03498  362 ARG A CG  
2620 C CD  . ARG A 182 ? 0.23256 0.20665 0.24073 -0.00039 0.03652  0.03822  362 ARG A CD  
2621 N NE  . ARG A 182 ? 0.24567 0.21273 0.24803 -0.00770 0.04024  0.04664  362 ARG A NE  
2622 C CZ  . ARG A 182 ? 0.25943 0.23323 0.27437 -0.01745 0.04369  0.05048  362 ARG A CZ  
2623 N NH1 . ARG A 182 ? 0.25740 0.24901 0.29244 -0.01806 0.04398  0.04637  362 ARG A NH1 
2624 N NH2 . ARG A 182 ? 0.32511 0.28668 0.33096 -0.02726 0.04603  0.05872  362 ARG A NH2 
2638 N N   . LEU A 183 ? 0.21386 0.18486 0.18202 0.01947  0.01871  0.02581  363 LEU A N   
2639 C CA  . LEU A 183 ? 0.21552 0.19552 0.19137 0.01970  0.01292  0.01947  363 LEU A CA  
2640 C C   . LEU A 183 ? 0.19810 0.17281 0.18526 0.01808  0.01126  0.02102  363 LEU A C   
2641 O O   . LEU A 183 ? 0.22336 0.18632 0.20761 0.01953  0.01026  0.02601  363 LEU A O   
2642 C CB  . LEU A 183 ? 0.22840 0.21665 0.19478 0.02718  0.00599  0.01741  363 LEU A CB  
2643 C CG  . LEU A 183 ? 0.21222 0.21870 0.18611 0.02677  0.00080  0.01034  363 LEU A CG  
2644 C CD1 . LEU A 183 ? 0.23876 0.25342 0.21344 0.01780  0.00281  0.00456  363 LEU A CD1 
2645 C CD2 . LEU A 183 ? 0.23245 0.25147 0.19874 0.03787  -0.00625 0.00895  363 LEU A CD2 
2657 N N   . LEU A 184 ? 0.18705 0.16789 0.18421 0.01439  0.01048  0.01667  364 LEU A N   
2658 C CA  . LEU A 184 ? 0.17400 0.15154 0.18075 0.01282  0.00853  0.01717  364 LEU A CA  
2659 C C   . LEU A 184 ? 0.18514 0.17268 0.19370 0.01317  0.00441  0.01221  364 LEU A C   
2660 O O   . LEU A 184 ? 0.18318 0.17886 0.19076 0.00914  0.00517  0.00857  364 LEU A O   
2661 C CB  . LEU A 184 ? 0.19649 0.17263 0.21277 0.00832  0.01270  0.01793  364 LEU A CB  
2662 C CG  . LEU A 184 ? 0.19635 0.17201 0.22219 0.00662  0.00984  0.01748  364 LEU A CG  
2663 C CD1 . LEU A 184 ? 0.22584 0.19541 0.25445 0.00584  0.00721  0.02051  364 LEU A CD1 
2664 C CD2 . LEU A 184 ? 0.20665 0.18368 0.24006 0.00579  0.01282  0.01752  364 LEU A CD2 
2676 N N   . PHE A 185 ? 0.17916 0.16520 0.18895 0.01683  0.00047  0.01188  365 PHE A N   
2677 C CA  . PHE A 185 ? 0.16728 0.16501 0.17972 0.01655  -0.00191 0.00760  365 PHE A CA  
2678 C C   . PHE A 185 ? 0.17442 0.16371 0.19170 0.01518  -0.00336 0.00839  365 PHE A C   
2679 O O   . PHE A 185 ? 0.18544 0.16179 0.20288 0.01659  -0.00500 0.01075  365 PHE A O   
2680 C CB  . PHE A 185 ? 0.18123 0.18911 0.18841 0.02613  -0.00610 0.00450  365 PHE A CB  
2681 C CG  . PHE A 185 ? 0.17777 0.19817 0.17953 0.03077  -0.00714 0.00312  365 PHE A CG  
2682 C CD1 . PHE A 185 ? 0.18901 0.19638 0.18156 0.03758  -0.00835 0.00685  365 PHE A CD1 
2683 C CD2 . PHE A 185 ? 0.19329 0.23944 0.19793 0.02738  -0.00735 -0.00172 365 PHE A CD2 
2684 C CE1 . PHE A 185 ? 0.20637 0.22575 0.19180 0.04387  -0.01068 0.00566  365 PHE A CE1 
2685 C CE2 . PHE A 185 ? 0.20999 0.27228 0.21045 0.03188  -0.00987 -0.00396 365 PHE A CE2 
2686 C CZ  . PHE A 185 ? 0.22292 0.27180 0.21332 0.04161  -0.01202 -0.00035 365 PHE A CZ  
2696 N N   . PHE A 186 ? 0.17336 0.16944 0.19281 0.01118  -0.00320 0.00651  366 PHE A N   
2697 C CA  . PHE A 186 ? 0.16890 0.15978 0.19026 0.01141  -0.00594 0.00642  366 PHE A CA  
2698 C C   . PHE A 186 ? 0.17096 0.17312 0.18914 0.00882  -0.00560 0.00416  366 PHE A C   
2699 O O   . PHE A 186 ? 0.15289 0.16300 0.16909 0.00261  -0.00246 0.00398  366 PHE A O   
2700 C CB  . PHE A 186 ? 0.17336 0.15422 0.20134 0.00787  -0.00562 0.00982  366 PHE A CB  
2701 C CG  . PHE A 186 ? 0.17594 0.15592 0.20470 0.00412  -0.00216 0.01138  366 PHE A CG  
2702 C CD1 . PHE A 186 ? 0.19146 0.16939 0.21658 0.00205  -0.00308 0.01172  366 PHE A CD1 
2703 C CD2 . PHE A 186 ? 0.18614 0.16387 0.21587 0.00368  0.00183  0.01256  366 PHE A CD2 
2704 C CE1 . PHE A 186 ? 0.20196 0.17154 0.22311 0.00028  -0.00086 0.01326  366 PHE A CE1 
2705 C CE2 . PHE A 186 ? 0.18696 0.15903 0.21392 0.00253  0.00443  0.01278  366 PHE A CE2 
2706 C CZ  . PHE A 186 ? 0.18814 0.15398 0.21000 0.00107  0.00278  0.01314  366 PHE A CZ  
2716 N N   . TRP A 187 ? 0.16398 0.16628 0.17967 0.01233  -0.00870 0.00225  367 TRP A N   
2717 C CA  . TRP A 187 ? 0.15491 0.16814 0.16569 0.00883  -0.00727 0.00124  367 TRP A CA  
2718 C C   . TRP A 187 ? 0.16527 0.16898 0.17434 0.00037  -0.00534 0.00579  367 TRP A C   
2719 O O   . TRP A 187 ? 0.18147 0.17191 0.19343 0.00159  -0.00772 0.00836  367 TRP A O   
2720 C CB  . TRP A 187 ? 0.17310 0.18542 0.17889 0.01456  -0.01102 -0.00159 367 TRP A CB  
2721 C CG  . TRP A 187 ? 0.17558 0.18927 0.17799 0.02564  -0.01422 -0.00697 367 TRP A CG  
2722 C CD1 . TRP A 187 ? 0.18925 0.18697 0.18730 0.03121  -0.01986 -0.00963 367 TRP A CD1 
2723 C CD2 . TRP A 187 ? 0.16455 0.19528 0.16496 0.03370  -0.01295 -0.01117 367 TRP A CD2 
2724 N NE1 . TRP A 187 ? 0.21030 0.20743 0.20101 0.04284  -0.02208 -0.01494 367 TRP A NE1 
2725 C CE2 . TRP A 187 ? 0.18542 0.20469 0.17804 0.04643  -0.01799 -0.01597 367 TRP A CE2 
2726 C CE3 . TRP A 187 ? 0.18109 0.23637 0.18499 0.03160  -0.00881 -0.01192 367 TRP A CE3 
2727 C CZ2 . TRP A 187 ? 0.21760 0.24785 0.20495 0.06042  -0.01899 -0.02110 367 TRP A CZ2 
2728 C CZ3 . TRP A 187 ? 0.19994 0.27259 0.20217 0.04414  -0.00993 -0.01710 367 TRP A CZ3 
2729 C CH2 . TRP A 187 ? 0.21666 0.27641 0.21010 0.06024  -0.01498 -0.02158 367 TRP A CH2 
2740 N N   . SER A 188 ? 0.18144 0.19197 0.18450 -0.00812 -0.00145 0.00666  368 SER A N   
2741 C CA  . SER A 188 ? 0.17701 0.17103 0.17273 -0.01564 0.00008  0.01115  368 SER A CA  
2742 C C   . SER A 188 ? 0.18698 0.17165 0.17373 -0.01537 -0.00198 0.01459  368 SER A C   
2743 O O   . SER A 188 ? 0.19111 0.15677 0.16949 -0.01776 -0.00223 0.01893  368 SER A O   
2744 C CB  . SER A 188 ? 0.16597 0.16602 0.15447 -0.02832 0.00460  0.01109  368 SER A CB  
2745 O OG  . SER A 188 ? 0.17222 0.18509 0.16754 -0.02896 0.00561  0.00725  368 SER A OG  
2751 N N   . ASP A 189 ? 0.18624 0.18239 0.17136 -0.01157 -0.00360 0.01254  369 ASP A N   
2752 C CA  . ASP A 189 ? 0.19782 0.18717 0.17091 -0.01171 -0.00551 0.01575  369 ASP A CA  
2753 C C   . ASP A 189 ? 0.22090 0.19760 0.19782 -0.00307 -0.01262 0.01659  369 ASP A C   
2754 O O   . ASP A 189 ? 0.21530 0.18759 0.20427 0.00060  -0.01459 0.01593  369 ASP A O   
2755 C CB  . ASP A 189 ? 0.19155 0.20124 0.15906 -0.01127 -0.00346 0.01229  369 ASP A CB  
2756 C CG  . ASP A 189 ? 0.24619 0.26361 0.22075 0.00067  -0.00794 0.00537  369 ASP A CG  
2757 O OD1 . ASP A 189 ? 0.22362 0.22896 0.20621 0.00615  -0.01327 0.00431  369 ASP A OD1 
2758 O OD2 . ASP A 189 ? 0.23993 0.27600 0.21054 0.00445  -0.00582 0.00056  369 ASP A OD2 
2763 N N   . ARG A 190 ? 0.23909 0.22341 0.17128 -0.01455 0.04011  0.00374  370 ARG A N   
2764 C CA  . ARG A 190 ? 0.26156 0.23878 0.17915 0.00960  0.02182  0.01746  370 ARG A CA  
2765 C C   . ARG A 190 ? 0.23923 0.25288 0.19737 0.01451  -0.00401 0.00768  370 ARG A C   
2766 O O   . ARG A 190 ? 0.23450 0.25864 0.19708 0.02853  -0.01789 0.00669  370 ARG A O   
2767 C CB  . ARG A 190 ? 0.32165 0.28219 0.19035 0.02873  0.02714  0.02372  370 ARG A CB  
2768 C CG  . ARG A 190 ? 0.40380 0.30288 0.21262 0.03644  0.06088  0.04291  370 ARG A CG  
2769 C CD  . ARG A 190 ? 0.51458 0.39308 0.26627 0.05507  0.07464  0.04986  370 ARG A CD  
2770 N NE  . ARG A 190 ? 0.76495 0.61455 0.47427 0.09343  0.07526  0.06757  370 ARG A NE  
2771 C CZ  . ARG A 190 ? 0.67653 0.46738 0.34765 0.09983  0.10845  0.07893  370 ARG A CZ  
2772 N NH1 . ARG A 190 ? 0.80405 0.56186 0.47923 0.06495  0.14306  0.07180  370 ARG A NH1 
2773 N NH2 . ARG A 190 ? 0.87638 0.64328 0.50619 0.14447  0.10952  0.09293  370 ARG A NH2 
2787 N N   . ARG A 191 ? 0.19859 0.23079 0.18516 0.00551  -0.00629 -0.00278 371 ARG A N   
2788 C CA  . ARG A 191 ? 0.18557 0.22903 0.20442 0.00946  -0.01697 -0.00903 371 ARG A CA  
2789 C C   . ARG A 191 ? 0.19888 0.23425 0.23277 0.00995  -0.01725 -0.00040 371 ARG A C   
2790 O O   . ARG A 191 ? 0.19149 0.22873 0.25014 0.00954  -0.01816 -0.00845 371 ARG A O   
2791 C CB  . ARG A 191 ? 0.18025 0.23114 0.21397 0.01017  -0.01369 -0.01561 371 ARG A CB  
2792 C CG  . ARG A 191 ? 0.18444 0.24762 0.21440 0.00976  -0.01449 -0.03000 371 ARG A CG  
2793 C CD  . ARG A 191 ? 0.20635 0.28105 0.24676 0.01664  -0.01121 -0.03752 371 ARG A CD  
2794 N NE  . ARG A 191 ? 0.18898 0.28708 0.22395 0.01475  -0.00689 -0.04105 371 ARG A NE  
2795 C CZ  . ARG A 191 ? 0.20939 0.33814 0.25299 0.02728  -0.00726 -0.05391 371 ARG A CZ  
2796 N NH1 . ARG A 191 ? 0.20799 0.33085 0.25762 0.04707  -0.00941 -0.05540 371 ARG A NH1 
2797 N NH2 . ARG A 191 ? 0.19277 0.36199 0.24081 0.02099  -0.00259 -0.07087 371 ARG A NH2 
2811 N N   . ASN A 192 ? 0.17293 0.20025 0.19599 0.00746  -0.01180 0.01064  372 ASN A N   
2812 C CA  . ASN A 192 ? 0.16703 0.18891 0.20233 0.00831  -0.01030 0.01866  372 ASN A CA  
2813 C C   . ASN A 192 ? 0.19416 0.20574 0.21468 0.00876  -0.00855 0.02569  372 ASN A C   
2814 O O   . ASN A 192 ? 0.18478 0.19193 0.20083 0.00353  -0.00024 0.02942  372 ASN A O   
2815 C CB  . ASN A 192 ? 0.15571 0.18482 0.19245 0.01185  -0.00497 0.02202  372 ASN A CB  
2816 C CG  . ASN A 192 ? 0.17631 0.20122 0.21937 0.02369  -0.00223 0.02214  372 ASN A CG  
2817 O OD1 . ASN A 192 ? 0.18031 0.18482 0.23702 0.02230  0.00395  0.02173  372 ASN A OD1 
2818 N ND2 . ASN A 192 ? 0.14935 0.19416 0.18381 0.03693  -0.00281 0.01895  372 ASN A ND2 
2825 N N   . PRO A 193 ? 0.16948 0.18162 0.18180 0.01949  -0.01579 0.02434  373 PRO A N   
2826 C CA  . PRO A 193 ? 0.16764 0.16845 0.16704 0.02927  -0.01418 0.03236  373 PRO A CA  
2827 C C   . PRO A 193 ? 0.17263 0.18143 0.20197 0.02193  -0.01334 0.03189  373 PRO A C   
2828 O O   . PRO A 193 ? 0.17368 0.19440 0.23140 0.01487  -0.01344 0.02464  373 PRO A O   
2829 C CB  . PRO A 193 ? 0.19701 0.21848 0.18644 0.05348  -0.02865 0.02431  373 PRO A CB  
2830 C CG  . PRO A 193 ? 0.20505 0.24307 0.19524 0.05148  -0.03444 0.01251  373 PRO A CG  
2831 C CD  . PRO A 193 ? 0.16406 0.19823 0.18238 0.02798  -0.02743 0.00995  373 PRO A CD  
2839 N N   . HIS A 194 ? 0.19953 0.19373 0.21891 0.02345  -0.00612 0.03977  374 HIS A N   
2840 C CA  . HIS A 194 ? 0.18129 0.18332 0.22365 0.01704  -0.00288 0.03990  374 HIS A CA  
2841 C C   . HIS A 194 ? 0.15812 0.14853 0.19046 0.02483  0.00152  0.04386  374 HIS A C   
2842 O O   . HIS A 194 ? 0.20279 0.16555 0.20504 0.03232  0.00988  0.04985  374 HIS A O   
2843 C CB  . HIS A 194 ? 0.18679 0.19152 0.23058 0.00762  0.00473  0.04243  374 HIS A CB  
2844 C CG  . HIS A 194 ? 0.16696 0.16987 0.19421 0.00033  0.01265  0.03757  374 HIS A CG  
2845 N ND1 . HIS A 194 ? 0.18095 0.18361 0.19863 -0.00415 0.01450  0.03181  374 HIS A ND1 
2846 C CD2 . HIS A 194 ? 0.17689 0.18221 0.20154 -0.00787 0.02418  0.02978  374 HIS A CD2 
2847 C CE1 . HIS A 194 ? 0.19257 0.19716 0.20505 -0.01749 0.02989  0.01882  374 HIS A CE1 
2848 N NE2 . HIS A 194 ? 0.17912 0.18599 0.19721 -0.02074 0.03623  0.01538  374 HIS A NE2 
2856 N N   . GLU A 195 ? 0.17488 0.17976 0.23066 0.02377  0.00147  0.04031  375 GLU A N   
2857 C CA  . GLU A 195 ? 0.18483 0.18309 0.23693 0.03170  0.00592  0.04162  375 GLU A CA  
2858 C C   . GLU A 195 ? 0.16903 0.17451 0.23654 0.01858  0.01538  0.04154  375 GLU A C   
2859 O O   . GLU A 195 ? 0.18329 0.19920 0.26584 0.01135  0.01852  0.04146  375 GLU A O   
2860 C CB  . GLU A 195 ? 0.22277 0.24827 0.28991 0.05161  -0.00640 0.03021  375 GLU A CB  
2861 C CG  . GLU A 195 ? 0.23123 0.29371 0.34426 0.03773  -0.00708 0.01165  375 GLU A CG  
2862 C CD  . GLU A 195 ? 0.28430 0.39979 0.42554 0.05308  -0.02150 -0.01721 375 GLU A CD  
2863 O OE1 . GLU A 195 ? 0.29245 0.42200 0.41078 0.07982  -0.03800 -0.02047 375 GLU A OE1 
2864 O OE2 . GLU A 195 ? 0.28370 0.43319 0.47129 0.03882  -0.01369 -0.04162 375 GLU A OE2 
2871 N N   . VAL A 196 ? 0.17636 0.17048 0.23429 0.01790  0.02467  0.04157  376 VAL A N   
2872 C CA  . VAL A 196 ? 0.17290 0.18126 0.24274 0.01214  0.03209  0.03874  376 VAL A CA  
2873 C C   . VAL A 196 ? 0.16938 0.18497 0.25603 0.02177  0.03087  0.03386  376 VAL A C   
2874 O O   . VAL A 196 ? 0.18059 0.18040 0.25635 0.03512  0.03209  0.03272  376 VAL A O   
2875 C CB  . VAL A 196 ? 0.16812 0.17591 0.22673 0.00352  0.04331  0.03056  376 VAL A CB  
2876 C CG1 . VAL A 196 ? 0.18490 0.21502 0.25124 0.00310  0.04926  0.02593  376 VAL A CG1 
2877 C CG2 . VAL A 196 ? 0.17414 0.19594 0.22430 -0.00396 0.04263  0.02460  376 VAL A CG2 
2887 N N   . GLN A 197 ? 0.16026 0.19689 0.27229 0.01663  0.03331  0.02906  377 GLN A N   
2888 C CA  . GLN A 197 ? 0.13748 0.19811 0.27716 0.02291  0.03290  0.01433  377 GLN A CA  
2889 C C   . GLN A 197 ? 0.15655 0.21424 0.29250 0.02379  0.04262  0.01438  377 GLN A C   
2890 O O   . GLN A 197 ? 0.15321 0.20068 0.27216 0.01508  0.05206  0.02207  377 GLN A O   
2891 C CB  . GLN A 197 ? 0.17172 0.25309 0.34654 0.00747  0.04458  0.00089  377 GLN A CB  
2892 C CG  . GLN A 197 ? 0.15653 0.24308 0.34076 0.00385  0.03810  -0.00628 377 GLN A CG  
2893 C CD  . GLN A 197 ? 0.17908 0.28455 0.40790 -0.01685 0.05830  -0.03123 377 GLN A CD  
2894 O OE1 . GLN A 197 ? 0.21605 0.30093 0.44269 -0.03079 0.08295  -0.02958 377 GLN A OE1 
2895 N NE2 . GLN A 197 ? 0.22047 0.35632 0.47147 -0.01729 0.04683  -0.05719 377 GLN A NE2 
2904 N N   . PRO A 198 ? 0.17148 0.24659 0.32324 0.03855  0.03914  0.00158  378 PRO A N   
2905 C CA  . PRO A 198 ? 0.18206 0.24971 0.32867 0.04179  0.04895  -0.00014 378 PRO A CA  
2906 C C   . PRO A 198 ? 0.19231 0.26783 0.34296 0.02201  0.06522  0.00113  378 PRO A C   
2907 O O   . PRO A 198 ? 0.17423 0.26505 0.34352 0.01069  0.07567  -0.00179 378 PRO A O   
2908 C CB  . PRO A 198 ? 0.19095 0.29115 0.36288 0.06380  0.04162  -0.01836 378 PRO A CB  
2909 C CG  . PRO A 198 ? 0.23582 0.34939 0.40476 0.08498  0.02280  -0.02186 378 PRO A CG  
2910 C CD  . PRO A 198 ? 0.18110 0.28967 0.35188 0.06082  0.02326  -0.01546 378 PRO A CD  
2918 N N   . ALA A 199 ? 0.20924 0.27328 0.34020 0.01935  0.07238  0.00223  379 ALA A N   
2919 C CA  . ALA A 199 ? 0.15760 0.23707 0.28009 0.01102  0.08545  0.00190  379 ALA A CA  
2920 C C   . ALA A 199 ? 0.16102 0.25324 0.29689 0.01332  0.09489  -0.01211 379 ALA A C   
2921 O O   . ALA A 199 ? 0.18310 0.26157 0.32059 0.01993  0.09447  -0.02219 379 ALA A O   
2922 C CB  . ALA A 199 ? 0.19195 0.27345 0.28950 0.00776  0.08433  -0.00062 379 ALA A CB  
2928 N N   . TYR A 200 ? 0.16323 0.27369 0.30288 0.00902  0.10935  -0.01207 380 TYR A N   
2929 C CA  . TYR A 200 ? 0.16042 0.28595 0.31035 0.00996  0.11658  -0.02609 380 TYR A CA  
2930 C C   . TYR A 200 ? 0.19171 0.33206 0.31306 0.01005  0.12600  -0.02706 380 TYR A C   
2931 O O   . TYR A 200 ? 0.24135 0.39464 0.36641 0.01077  0.13280  -0.03705 380 TYR A O   
2932 C CB  . TYR A 200 ? 0.19670 0.33313 0.37049 0.00467  0.12163  -0.03149 380 TYR A CB  
2933 C CG  . TYR A 200 ? 0.20455 0.34808 0.40787 0.01096  0.10690  -0.04025 380 TYR A CG  
2934 C CD1 . TYR A 200 ? 0.24529 0.39665 0.46228 0.03279  0.09406  -0.05209 380 TYR A CD1 
2935 C CD2 . TYR A 200 ? 0.24437 0.38634 0.45625 0.00088  0.10699  -0.03842 380 TYR A CD2 
2936 C CE1 . TYR A 200 ? 0.25644 0.42136 0.48745 0.05101  0.07649  -0.05918 380 TYR A CE1 
2937 C CE2 . TYR A 200 ? 0.25346 0.41572 0.49023 0.01020  0.08975  -0.05222 380 TYR A CE2 
2938 C CZ  . TYR A 200 ? 0.18304 0.36111 0.42593 0.03849  0.07199  -0.06153 380 TYR A CZ  
2939 O OH  . TYR A 200 ? 0.39374 0.59513 0.64550 0.05757  0.05134  -0.07266 380 TYR A OH  
2949 N N   . ALA A 201 ? 0.22004 0.36702 0.31262 0.01399  0.12565  -0.01950 381 ALA A N   
2950 C CA  . ALA A 201 ? 0.20450 0.37855 0.26887 0.02250  0.12826  -0.02870 381 ALA A CA  
2951 C C   . ALA A 201 ? 0.19238 0.37909 0.24859 0.02140  0.11260  -0.04132 381 ALA A C   
2952 O O   . ALA A 201 ? 0.19847 0.37061 0.26408 0.01623  0.10677  -0.03554 381 ALA A O   
2953 C CB  . ALA A 201 ? 0.25663 0.43005 0.28030 0.03416  0.14080  -0.01239 381 ALA A CB  
2959 N N   . THR A 202 ? 0.23098 0.28009 0.32708 0.08859  0.09176  0.04315  382 THR A N   
2960 C CA  . THR A 202 ? 0.24915 0.26161 0.33335 0.08140  0.09292  0.02990  382 THR A CA  
2961 C C   . THR A 202 ? 0.22324 0.24776 0.29483 0.06172  0.06511  0.01769  382 THR A C   
2962 O O   . THR A 202 ? 0.22944 0.25411 0.28865 0.04938  0.05622  0.00549  382 THR A O   
2963 C CB  . THR A 202 ? 0.31036 0.27459 0.37600 0.07098  0.11216  0.00735  382 THR A CB  
2964 O OG1 . THR A 202 ? 0.33606 0.27979 0.40338 0.07968  0.13444  0.01787  382 THR A OG1 
2965 C CG2 . THR A 202 ? 0.29487 0.23039 0.34670 0.05738  0.11479  -0.00902 382 THR A CG2 
2973 N N   . ARG A 203 ? 0.17896 0.21046 0.25314 0.06107  0.05582  0.02310  383 ARG A N   
2974 C CA  . ARG A 203 ? 0.17341 0.21498 0.23821 0.04602  0.03584  0.01572  383 ARG A CA  
2975 C C   . ARG A 203 ? 0.19379 0.21002 0.24897 0.04143  0.03385  0.00669  383 ARG A C   
2976 O O   . ARG A 203 ? 0.21246 0.22042 0.27448 0.04936  0.04195  0.01383  383 ARG A O   
2977 C CB  . ARG A 203 ? 0.14994 0.23572 0.22656 0.04533  0.02762  0.02991  383 ARG A CB  
2978 C CG  . ARG A 203 ? 0.14709 0.23710 0.21190 0.02626  0.01496  0.01967  383 ARG A CG  
2979 C CD  . ARG A 203 ? 0.14997 0.28792 0.22339 0.02084  0.00957  0.03020  383 ARG A CD  
2980 N NE  . ARG A 203 ? 0.13294 0.27825 0.19305 -0.00385 0.00433  0.01692  383 ARG A NE  
2981 C CZ  . ARG A 203 ? 0.13607 0.26263 0.18806 -0.00822 0.00112  0.01157  383 ARG A CZ  
2982 N NH1 . ARG A 203 ? 0.13856 0.23507 0.19208 0.00723  0.00003  0.01504  383 ARG A NH1 
2983 N NH2 . ARG A 203 ? 0.14545 0.28368 0.18585 -0.03225 0.00232  0.00001  383 ARG A NH2 
2997 N N   . TYR A 204 ? 0.19520 0.20439 0.23603 0.03076  0.02550  -0.00505 384 TYR A N   
2998 C CA  . TYR A 204 ? 0.18397 0.18283 0.21626 0.02492  0.02254  -0.01275 384 TYR A CA  
2999 C C   . TYR A 204 ? 0.20298 0.20980 0.23119 0.02183  0.01070  -0.00973 384 TYR A C   
3000 O O   . TYR A 204 ? 0.17173 0.18222 0.19589 0.02061  0.00932  -0.00715 384 TYR A O   
3001 C CB  . TYR A 204 ? 0.20478 0.20392 0.22302 0.01594  0.02607  -0.02590 384 TYR A CB  
3002 C CG  . TYR A 204 ? 0.21840 0.20201 0.23329 0.01145  0.04447  -0.03706 384 TYR A CG  
3003 C CD1 . TYR A 204 ? 0.23663 0.19267 0.25263 0.00886  0.06360  -0.04364 384 TYR A CD1 
3004 C CD2 . TYR A 204 ? 0.23353 0.22484 0.24125 0.00820  0.04849  -0.04247 384 TYR A CD2 
3005 C CE1 . TYR A 204 ? 0.26826 0.19794 0.27755 0.00222  0.09057  -0.05700 384 TYR A CE1 
3006 C CE2 . TYR A 204 ? 0.24187 0.21461 0.24330 0.00083  0.07032  -0.05636 384 TYR A CE2 
3007 C CZ  . TYR A 204 ? 0.27236 0.21084 0.27383 -0.00294 0.09378  -0.06487 384 TYR A CZ  
3008 O OH  . TYR A 204 ? 0.31036 0.22050 0.30291 -0.01221 0.12319  -0.08005 384 TYR A OH  
3018 N N   . ALA A 205 ? 0.18341 0.18699 0.21108 0.02008  0.00753  -0.01075 385 ALA A N   
3019 C CA  . ALA A 205 ? 0.16607 0.17241 0.18948 0.01865  0.00127  -0.00798 385 ALA A CA  
3020 C C   . ALA A 205 ? 0.17581 0.18336 0.19709 0.01598  -0.00079 -0.01182 385 ALA A C   
3021 O O   . ALA A 205 ? 0.19261 0.19198 0.21668 0.01280  0.00441  -0.01687 385 ALA A O   
3022 C CB  . ALA A 205 ? 0.19767 0.20720 0.22534 0.01546  -0.00031 -0.00377 385 ALA A CB  
3028 N N   . ILE A 206 ? 0.16970 0.18672 0.18586 0.01777  -0.00365 -0.00822 386 ILE A N   
3029 C CA  . ILE A 206 ? 0.15545 0.18492 0.17030 0.01401  -0.00650 -0.01057 386 ILE A CA  
3030 C C   . ILE A 206 ? 0.17925 0.20141 0.19576 0.01891  -0.00739 -0.00332 386 ILE A C   
3031 O O   . ILE A 206 ? 0.16949 0.18765 0.18271 0.02698  -0.00136 0.00531  386 ILE A O   
3032 C CB  . ILE A 206 ? 0.15724 0.22356 0.16563 0.01333  -0.00740 -0.00869 386 ILE A CB  
3033 C CG1 . ILE A 206 ? 0.15333 0.22931 0.15575 0.00261  -0.00406 -0.02037 386 ILE A CG1 
3034 C CG2 . ILE A 206 ? 0.14902 0.23940 0.15722 0.00611  -0.01053 -0.01133 386 ILE A CG2 
3035 C CD1 . ILE A 206 ? 0.18904 0.31974 0.18308 -0.00256 -0.00591 -0.01864 386 ILE A CD1 
3047 N N   . SER A 207 ? 0.16979 0.18603 0.18997 0.01393  -0.00992 -0.00666 387 SER A N   
3048 C CA  . SER A 207 ? 0.17614 0.18585 0.19627 0.01512  -0.00977 -0.00261 387 SER A CA  
3049 C C   . SER A 207 ? 0.14875 0.17134 0.16941 0.01441  -0.01181 -0.00222 387 SER A C   
3050 O O   . SER A 207 ? 0.16610 0.19635 0.18794 0.00639  -0.01332 -0.00914 387 SER A O   
3051 C CB  . SER A 207 ? 0.19009 0.19410 0.21445 0.01023  -0.01152 -0.00290 387 SER A CB  
3052 O OG  . SER A 207 ? 0.19918 0.20598 0.22465 0.00848  -0.01022 -0.00195 387 SER A OG  
3058 N N   . VAL A 208 ? 0.16823 0.18965 0.18708 0.02064  -0.00736 0.00452  388 VAL A N   
3059 C CA  . VAL A 208 ? 0.16551 0.19890 0.18651 0.01995  -0.00891 0.00596  388 VAL A CA  
3060 C C   . VAL A 208 ? 0.16879 0.18030 0.18661 0.01863  -0.00312 0.00580  388 VAL A C   
3061 O O   . VAL A 208 ? 0.19652 0.18819 0.20805 0.01802  0.00687  0.00491  388 VAL A O   
3062 C CB  . VAL A 208 ? 0.20005 0.26808 0.22288 0.03119  -0.00563 0.01805  388 VAL A CB  
3063 C CG1 . VAL A 208 ? 0.17448 0.28193 0.19722 0.02541  -0.01174 0.01559  388 VAL A CG1 
3064 C CG2 . VAL A 208 ? 0.27160 0.32540 0.29207 0.04967  0.01053  0.03336  388 VAL A CG2 
3074 N N   . TRP A 209 ? 0.15401 0.16981 0.17374 0.01413  -0.00635 0.00421  389 TRP A N   
3075 C CA  . TRP A 209 ? 0.15063 0.15197 0.16483 0.01032  0.00067  0.00266  389 TRP A CA  
3076 C C   . TRP A 209 ? 0.17638 0.18563 0.19238 0.01858  0.00699  0.00920  389 TRP A C   
3077 O O   . TRP A 209 ? 0.16604 0.19877 0.18864 0.01790  -0.00120 0.01068  389 TRP A O   
3078 C CB  . TRP A 209 ? 0.16633 0.17131 0.18117 -0.00071 -0.00717 -0.00111 389 TRP A CB  
3079 C CG  . TRP A 209 ? 0.14358 0.15334 0.15871 -0.00603 -0.01085 -0.00170 389 TRP A CG  
3080 C CD1 . TRP A 209 ? 0.16382 0.17943 0.17113 -0.01776 -0.00685 -0.00645 389 TRP A CD1 
3081 C CD2 . TRP A 209 ? 0.16930 0.18382 0.19267 -0.00140 -0.01567 0.00277  389 TRP A CD2 
3082 N NE1 . TRP A 209 ? 0.15705 0.19297 0.17007 -0.01861 -0.01293 -0.00149 389 TRP A NE1 
3083 C CE2 . TRP A 209 ? 0.14481 0.17462 0.16841 -0.00529 -0.01668 0.00587  389 TRP A CE2 
3084 C CE3 . TRP A 209 ? 0.17220 0.18051 0.20107 0.00259  -0.01497 0.00272  389 TRP A CE3 
3085 C CZ2 . TRP A 209 ? 0.17500 0.21328 0.20781 0.00248  -0.01699 0.01492  389 TRP A CZ2 
3086 C CZ3 . TRP A 209 ? 0.19353 0.19770 0.22788 0.00663  -0.01110 0.00678  389 TRP A CZ3 
3087 C CH2 . TRP A 209 ? 0.21751 0.23595 0.25546 0.01028  -0.01217 0.01558  389 TRP A CH2 
3098 N N   . TYR A 210 ? 0.16266 0.15162 0.17213 0.02523  0.02616  0.01274  390 TYR A N   
3099 C CA  . TYR A 210 ? 0.16920 0.16297 0.18128 0.03864  0.03930  0.02359  390 TYR A CA  
3100 C C   . TYR A 210 ? 0.19410 0.17711 0.20035 0.02471  0.03996  0.01320  390 TYR A C   
3101 O O   . TYR A 210 ? 0.22915 0.19164 0.22346 0.00715  0.04449  -0.00049 390 TYR A O   
3102 C CB  . TYR A 210 ? 0.20543 0.17311 0.21298 0.05737  0.06994  0.03633  390 TYR A CB  
3103 C CG  . TYR A 210 ? 0.19333 0.18908 0.20943 0.07687  0.06812  0.05469  390 TYR A CG  
3104 C CD1 . TYR A 210 ? 0.18189 0.23113 0.21082 0.09689  0.06533  0.07681  390 TYR A CD1 
3105 C CD2 . TYR A 210 ? 0.21009 0.19114 0.22137 0.07194  0.06672  0.04941  390 TYR A CD2 
3106 C CE1 . TYR A 210 ? 0.16604 0.25240 0.19466 0.10332  0.05913  0.09056  390 TYR A CE1 
3107 C CE2 . TYR A 210 ? 0.20800 0.22130 0.22590 0.08829  0.06382  0.06628  390 TYR A CE2 
3108 C CZ  . TYR A 210 ? 0.18064 0.24777 0.20519 0.10105  0.05927  0.08561  390 TYR A CZ  
3109 O OH  . TYR A 210 ? 0.19908 0.30433 0.22198 0.10620  0.05514  0.09791  390 TYR A OH  
3119 N N   . PHE A 211 ? 0.18268 0.18796 0.19647 0.03023  0.03623  0.01974  391 PHE A N   
3120 C CA  . PHE A 211 ? 0.17923 0.18052 0.18883 0.01900  0.03592  0.01256  391 PHE A CA  
3121 C C   . PHE A 211 ? 0.24144 0.22062 0.24481 0.02799  0.06348  0.01638  391 PHE A C   
3122 O O   . PHE A 211 ? 0.26963 0.25646 0.28106 0.05183  0.07921  0.03445  391 PHE A O   
3123 C CB  . PHE A 211 ? 0.18888 0.22509 0.20988 0.01773  0.01991  0.01628  391 PHE A CB  
3124 C CG  . PHE A 211 ? 0.15697 0.20178 0.18123 0.00572  0.00251  0.00982  391 PHE A CG  
3125 C CD1 . PHE A 211 ? 0.19081 0.21926 0.20957 -0.00448 -0.00244 0.00415  391 PHE A CD1 
3126 C CD2 . PHE A 211 ? 0.14982 0.22300 0.18168 0.00409  -0.00421 0.01046  391 PHE A CD2 
3127 C CE1 . PHE A 211 ? 0.20852 0.23783 0.23156 -0.00918 -0.00973 0.00336  391 PHE A CE1 
3128 C CE2 . PHE A 211 ? 0.16693 0.23467 0.19873 -0.00862 -0.01033 0.00184  391 PHE A CE2 
3129 C CZ  . PHE A 211 ? 0.16179 0.20246 0.19026 -0.01182 -0.01094 0.00031  391 PHE A CZ  
3139 N N   . ASP A 212 ? 0.24369 0.20204 0.23292 0.00946  0.07155  0.00155  392 ASP A N   
3140 C CA  . ASP A 212 ? 0.27781 0.21534 0.25980 0.01282  0.09810  0.00113  392 ASP A CA  
3141 C C   . ASP A 212 ? 0.23912 0.21046 0.23287 0.01702  0.08275  0.00872  392 ASP A C   
3142 O O   . ASP A 212 ? 0.22354 0.21547 0.21846 0.00174  0.05902  0.00247  392 ASP A O   
3143 C CB  . ASP A 212 ? 0.29850 0.20880 0.25646 -0.01754 0.11321  -0.02319 392 ASP A CB  
3144 C CG  . ASP A 212 ? 0.31159 0.19777 0.25912 -0.01904 0.14247  -0.02807 392 ASP A CG  
3145 O OD1 . ASP A 212 ? 0.37442 0.22424 0.32260 -0.00189 0.17080  -0.01850 392 ASP A OD1 
3146 O OD2 . ASP A 212 ? 0.34130 0.24761 0.28403 -0.03494 0.13095  -0.03597 392 ASP A OD2 
3151 N N   . ALA A 213 ? 0.25772 0.23678 0.26095 0.03934  0.09944  0.02502  393 ALA A N   
3152 C CA  . ALA A 213 ? 0.23399 0.25552 0.25076 0.04251  0.08445  0.03316  393 ALA A CA  
3153 C C   . ALA A 213 ? 0.24456 0.25803 0.25066 0.02000  0.07824  0.01763  393 ALA A C   
3154 O O   . ALA A 213 ? 0.22615 0.26595 0.23836 0.00933  0.05586  0.01595  393 ALA A O   
3155 C CB  . ALA A 213 ? 0.26500 0.30429 0.29406 0.07214  0.10816  0.05667  393 ALA A CB  
3161 N N   . ASP A 214 ? 0.27537 0.25255 0.26377 0.01105  0.10223  0.00606  394 ASP A N   
3162 C CA  . ASP A 214 ? 0.27841 0.26037 0.25655 -0.00902 0.09756  -0.00547 394 ASP A CA  
3163 C C   . ASP A 214 ? 0.24721 0.24472 0.21811 -0.03173 0.07243  -0.01503 394 ASP A C   
3164 O O   . ASP A 214 ? 0.24350 0.26489 0.21769 -0.03861 0.05610  -0.01176 394 ASP A O   
3165 C CB  . ASP A 214 ? 0.33938 0.28197 0.29636 -0.01870 0.13366  -0.01950 394 ASP A CB  
3166 C CG  . ASP A 214 ? 0.48830 0.41682 0.45417 0.00852  0.16389  -0.00421 394 ASP A CG  
3167 O OD1 . ASP A 214 ? 0.39793 0.36484 0.38704 0.03187  0.15236  0.01780  394 ASP A OD1 
3168 O OD2 . ASP A 214 ? 0.57579 0.45997 0.52809 0.00325  0.18757  -0.01313 394 ASP A OD2 
3173 N N   . GLU A 215 ? 0.24239 0.22976 0.20467 -0.04111 0.07194  -0.02319 395 GLU A N   
3174 C CA  . GLU A 215 ? 0.27800 0.29214 0.23755 -0.05629 0.04988  -0.02472 395 GLU A CA  
3175 C C   . GLU A 215 ? 0.21776 0.25000 0.19720 -0.04252 0.02749  -0.00914 395 GLU A C   
3176 O O   . GLU A 215 ? 0.22459 0.27748 0.20630 -0.04686 0.01555  -0.00171 395 GLU A O   
3177 C CB  . GLU A 215 ? 0.26952 0.27628 0.21826 -0.06865 0.05473  -0.03553 395 GLU A CB  
3178 C CG  . GLU A 215 ? 0.25473 0.30327 0.20150 -0.08244 0.03514  -0.03264 395 GLU A CG  
3179 C CD  . GLU A 215 ? 0.28709 0.33906 0.22542 -0.09607 0.03816  -0.04276 395 GLU A CD  
3180 O OE1 . GLU A 215 ? 0.41642 0.44174 0.33630 -0.11393 0.06284  -0.06316 395 GLU A OE1 
3181 O OE2 . GLU A 215 ? 0.24129 0.31747 0.19061 -0.08945 0.02097  -0.03111 395 GLU A OE2 
3188 N N   . ARG A 216 ? 0.18237 0.20833 0.17484 -0.02696 0.02596  -0.00339 396 ARG A N   
3189 C CA  . ARG A 216 ? 0.16121 0.20089 0.16764 -0.02226 0.01131  0.00411  396 ARG A CA  
3190 C C   . ARG A 216 ? 0.21364 0.26559 0.22547 -0.02504 0.00994  0.00773  396 ARG A C   
3191 O O   . ARG A 216 ? 0.17988 0.23357 0.19558 -0.02978 0.00482  0.01122  396 ARG A O   
3192 C CB  . ARG A 216 ? 0.21656 0.26032 0.23248 -0.01067 0.01117  0.00696  396 ARG A CB  
3193 C CG  . ARG A 216 ? 0.19110 0.24784 0.21616 -0.01440 0.00080  0.00718  396 ARG A CG  
3194 C CD  . ARG A 216 ? 0.17315 0.21500 0.19555 -0.01988 -0.00404 0.00677  396 ARG A CD  
3195 N NE  . ARG A 216 ? 0.21408 0.25539 0.24214 -0.02455 -0.00439 0.00371  396 ARG A NE  
3196 C CZ  . ARG A 216 ? 0.19451 0.21840 0.22286 -0.02564 -0.00107 0.00637  396 ARG A CZ  
3197 N NH1 . ARG A 216 ? 0.21474 0.23505 0.24110 -0.01954 -0.00158 0.01712  396 ARG A NH1 
3198 N NH2 . ARG A 216 ? 0.21287 0.22803 0.24295 -0.03374 0.00616  -0.00118 396 ARG A NH2 
3212 N N   . ALA A 217 ? 0.21017 0.26700 0.22197 -0.02150 0.01935  0.00793  397 ALA A N   
3213 C CA  . ALA A 217 ? 0.22631 0.29707 0.24234 -0.02645 0.01907  0.01039  397 ALA A CA  
3214 C C   . ALA A 217 ? 0.22778 0.29381 0.23449 -0.03676 0.01661  0.01167  397 ALA A C   
3215 O O   . ALA A 217 ? 0.21134 0.28001 0.22231 -0.04117 0.01478  0.01696  397 ALA A O   
3216 C CB  . ALA A 217 ? 0.20137 0.28016 0.21919 -0.01768 0.03247  0.01288  397 ALA A CB  
3222 N N   . ARG A 218 ? 0.21191 0.27486 0.20447 -0.04243 0.02006  0.00759  398 ARG A N   
3223 C CA  . ARG A 218 ? 0.22595 0.30541 0.20988 -0.05151 0.01628  0.01399  398 ARG A CA  
3224 C C   . ARG A 218 ? 0.24561 0.33050 0.23732 -0.04558 0.00841  0.02843  398 ARG A C   
3225 O O   . ARG A 218 ? 0.22211 0.31549 0.21617 -0.04280 0.01019  0.04381  398 ARG A O   
3226 C CB  . ARG A 218 ? 0.25077 0.34158 0.21513 -0.06670 0.02199  0.00318  398 ARG A CB  
3227 C CG  . ARG A 218 ? 0.30068 0.37877 0.25276 -0.07491 0.03942  -0.01094 398 ARG A CG  
3228 C CD  . ARG A 218 ? 0.35223 0.44108 0.27827 -0.10115 0.05159  -0.02899 398 ARG A CD  
3229 N NE  . ARG A 218 ? 0.45238 0.52877 0.37079 -0.10950 0.05770  -0.04143 398 ARG A NE  
3230 C CZ  . ARG A 218 ? 0.41843 0.45110 0.32839 -0.11113 0.08289  -0.05718 398 ARG A CZ  
3231 N NH1 . ARG A 218 ? 0.49351 0.49253 0.40389 -0.10018 0.10532  -0.05916 398 ARG A NH1 
3232 N NH2 . ARG A 218 ? 0.41205 0.43422 0.31401 -0.12141 0.08933  -0.06811 398 ARG A NH2 
3246 N N   . ALA A 219 ? 0.20555 0.28204 0.20169 -0.04094 0.00436  0.02623  399 ALA A N   
3247 C CA  . ALA A 219 ? 0.25324 0.32971 0.25722 -0.03253 0.00243  0.04056  399 ALA A CA  
3248 C C   . ALA A 219 ? 0.21440 0.26695 0.22817 -0.02890 0.01092  0.04447  399 ALA A C   
3249 O O   . ALA A 219 ? 0.25688 0.30241 0.27427 -0.02168 0.02107  0.06185  399 ALA A O   
3250 C CB  . ALA A 219 ? 0.22845 0.29868 0.23431 -0.03009 -0.00228 0.03382  399 ALA A CB  
3256 N N   . LYS A 220 ? 0.25950 0.30299 0.27686 -0.03482 0.01147  0.02986  400 LYS A N   
3257 C CA  . LYS A 220 ? 0.23375 0.26222 0.25648 -0.04236 0.02236  0.02622  400 LYS A CA  
3258 C C   . LYS A 220 ? 0.24273 0.26813 0.26346 -0.04564 0.03247  0.03490  400 LYS A C   
3259 O O   . LYS A 220 ? 0.27969 0.28003 0.30163 -0.04944 0.05044  0.03949  400 LYS A O   
3260 C CB  . LYS A 220 ? 0.30750 0.35245 0.33449 -0.05091 0.01850  0.01054  400 LYS A CB  
3261 C CG  . LYS A 220 ? 0.29697 0.34179 0.32622 -0.04939 0.01412  0.00417  400 LYS A CG  
3262 C CD  . LYS A 220 ? 0.44738 0.52246 0.48123 -0.06091 0.01343  -0.00767 400 LYS A CD  
3263 C CE  . LYS A 220 ? 0.58898 0.66587 0.62293 -0.06204 0.01081  -0.01386 400 LYS A CE  
3264 N NZ  . LYS A 220 ? 0.62601 0.71184 0.65756 -0.08821 0.02173  -0.03102 400 LYS A NZ  
3278 N N   . VAL A 221 ? 0.26007 0.30556 0.27613 -0.04544 0.02622  0.03639  401 VAL A N   
3279 C CA  . VAL A 221 ? 0.30304 0.34959 0.31618 -0.04781 0.03522  0.04657  401 VAL A CA  
3280 C C   . VAL A 221 ? 0.28481 0.32705 0.29648 -0.03578 0.04403  0.07142  401 VAL A C   
3281 O O   . VAL A 221 ? 0.32734 0.34950 0.34063 -0.03355 0.06296  0.08470  401 VAL A O   
3282 C CB  . VAL A 221 ? 0.27712 0.34707 0.28326 -0.05063 0.02861  0.04197  401 VAL A CB  
3283 C CG1 . VAL A 221 ? 0.29031 0.36784 0.29121 -0.05213 0.03610  0.05520  401 VAL A CG1 
3284 C CG2 . VAL A 221 ? 0.26100 0.33778 0.27329 -0.05524 0.02791  0.02670  401 VAL A CG2 
3294 N N   . LYS A 222 ? 0.27930 0.34350 0.28845 -0.02696 0.03417  0.08062  402 LYS A N   
3295 C CA  . LYS A 222 ? 0.34301 0.42243 0.35411 -0.01018 0.04246  0.11204  402 LYS A CA  
3296 C C   . LYS A 222 ? 0.32891 0.36269 0.34931 0.00128  0.06581  0.12351  402 LYS A C   
3297 O O   . LYS A 222 ? 0.36084 0.38221 0.38412 0.01583  0.08809  0.14975  402 LYS A O   
3298 C CB  . LYS A 222 ? 0.32995 0.45374 0.33712 -0.00840 0.02656  0.11551  402 LYS A CB  
3299 C CG  . LYS A 222 ? 0.38412 0.55798 0.37653 -0.02323 0.01522  0.10982  402 LYS A CG  
3300 C CD  . LYS A 222 ? 0.43197 0.65867 0.41591 -0.03214 0.00355  0.10794  402 LYS A CD  
3307 N N   . TYR A 223 ? 0.31513 0.32039 0.33872 -0.00596 0.06530  0.10246  403 TYR A N   
3308 C CA  . TYR A 223 ? 0.34765 0.30356 0.37586 -0.00150 0.09313  0.10639  403 TYR A CA  
3309 C C   . TYR A 223 ? 0.38487 0.29968 0.40991 -0.01584 0.12006  0.09856  403 TYR A C   
3310 O O   . TYR A 223 ? 0.42288 0.30438 0.44799 -0.00402 0.14456  0.10600  403 TYR A O   
3311 C CB  . TYR A 223 ? 0.37455 0.31935 0.40358 -0.01235 0.08426  0.08077  403 TYR A CB  
3312 C CG  . TYR A 223 ? 0.41603 0.30800 0.44533 -0.01674 0.11529  0.07478  403 TYR A CG  
3313 C CD1 . TYR A 223 ? 0.49234 0.36952 0.52648 0.00725  0.13043  0.09444  403 TYR A CD1 
3314 C CD2 . TYR A 223 ? 0.41721 0.28516 0.44048 -0.04577 0.12778  0.04433  403 TYR A CD2 
3315 C CE1 . TYR A 223 ? 0.52117 0.35461 0.55271 0.00499  0.15724  0.07950  403 TYR A CE1 
3316 C CE2 . TYR A 223 ? 0.51465 0.34544 0.53141 -0.05159 0.15116  0.02752  403 TYR A CE2 
3317 C CZ  . TYR A 223 ? 0.59360 0.40103 0.61407 -0.02598 0.16864  0.04471  403 TYR A CZ  
3318 O OH  . TYR A 223 ? 0.64652 0.41498 0.65895 -0.03257 0.19901  0.02568  403 TYR A OH  
3328 N N   . LEU A 224 ? 0.32043 0.24869 0.34190 -0.03818 0.10751  0.07396  404 LEU A N   
3329 C CA  . LEU A 224 ? 0.37128 0.26999 0.38872 -0.05968 0.13085  0.05898  404 LEU A CA  
3330 C C   . LEU A 224 ? 0.43229 0.32620 0.44723 -0.04797 0.14225  0.07936  404 LEU A C   
3331 O O   . LEU A 224 ? 0.43435 0.29924 0.44468 -0.05916 0.16234  0.06789  404 LEU A O   
3332 C CB  . LEU A 224 ? 0.35835 0.29218 0.37583 -0.08423 0.11116  0.03067  404 LEU A CB  
3333 C CG  . LEU A 224 ? 0.34886 0.29759 0.36785 -0.09679 0.09929  0.00754  404 LEU A CG  
3334 C CD1 . LEU A 224 ? 0.40446 0.40833 0.42750 -0.10586 0.07542  -0.00609 404 LEU A CD1 
3335 C CD2 . LEU A 224 ? 0.43169 0.34896 0.44265 -0.11659 0.12281  -0.01395 404 LEU A CD2 
3347 N N   . THR A 225 ? 0.37082 0.29939 0.38719 -0.02806 0.12942  0.10700  405 THR A N   
3348 C CA  . THR A 225 ? 0.38190 0.31569 0.39590 -0.01419 0.13833  0.12886  405 THR A CA  
3349 C C   . THR A 225 ? 0.46436 0.39637 0.48520 0.01888  0.15104  0.15838  405 THR A C   
3350 O O   . THR A 225 ? 0.55520 0.49615 0.57840 0.03541  0.16154  0.18034  405 THR A O   
3351 C CB  . THR A 225 ? 0.38268 0.37177 0.39271 -0.01587 0.11532  0.13693  405 THR A CB  
3352 O OG1 . THR A 225 ? 0.42939 0.46192 0.43981 -0.00591 0.09368  0.14575  405 THR A OG1 
3353 C CG2 . THR A 225 ? 0.41683 0.41318 0.42534 -0.04168 0.10341  0.10615  405 THR A CG2 
3361 N N   . GLY A 226 ? 0.55700 0.48218 0.58427 0.03051  0.15262  0.16035  406 GLY A N   
3362 C CA  . GLY A 226 ? 0.58493 0.52383 0.62562 0.06532  0.16561  0.19043  406 GLY A CA  
3363 C C   . GLY A 226 ? 0.66716 0.68002 0.71393 0.07681  0.13622  0.20731  406 GLY A C   
3364 O O   . GLY A 226 ? 0.80113 0.86942 0.85794 0.09645  0.13277  0.23409  406 GLY A O   
3368 N N   A GLU B 1   ? 0.88477 0.96916 0.43151 0.01001  -0.19014 -0.04929 523 GLU B N   
3369 N N   B GLU B 1   ? 0.82345 0.86657 0.32688 -0.01274 -0.15142 -0.05419 523 GLU B N   
3370 C CA  A GLU B 1   ? 0.76968 0.86529 0.39330 -0.00136 -0.16845 -0.06449 523 GLU B CA  
3371 C CA  B GLU B 1   ? 0.79041 0.86731 0.40013 -0.01838 -0.14246 -0.06813 523 GLU B CA  
3372 C C   A GLU B 1   ? 0.85179 0.90196 0.47490 0.01658  -0.16032 -0.02207 523 GLU B C   
3373 C C   B GLU B 1   ? 0.83032 0.85429 0.44887 -0.00771 -0.12450 -0.02640 523 GLU B C   
3374 O O   A GLU B 1   ? 0.87393 0.89367 0.45345 0.03653  -0.16803 0.01415  523 GLU B O   
3375 O O   B GLU B 1   ? 0.81689 0.78026 0.36674 -0.01015 -0.10063 -0.00009 523 GLU B O   
3376 C CB  A GLU B 1   ? 0.75917 0.84627 0.38142 -0.03755 -0.12749 -0.09012 523 GLU B CB  
3377 C CB  B GLU B 1   ? 0.74709 0.83522 0.41076 -0.05532 -0.10546 -0.10380 523 GLU B CB  
3378 C CG  A GLU B 1   ? 0.72855 0.83326 0.46483 -0.05809 -0.10128 -0.11065 523 GLU B CG  
3379 C CG  B GLU B 1   ? 0.60713 0.74082 0.28206 -0.06786 -0.11443 -0.14773 523 GLU B CG  
3380 C CD  A GLU B 1   ? 0.60453 0.71013 0.35854 -0.09144 -0.06713 -0.14505 523 GLU B CD  
3381 C CD  B GLU B 1   ? 0.58576 0.72825 0.33012 -0.10060 -0.07695 -0.18164 523 GLU B CD  
3392 N N   . LEU B 2   ? 0.91165 0.96028 0.61647 0.00180  -0.13280 -0.02428 524 LEU B N   
3393 C CA  . LEU B 2   ? 0.73297 0.74443 0.45619 0.01246  -0.11861 0.00833  524 LEU B CA  
3394 C C   . LEU B 2   ? 0.62532 0.59996 0.35441 -0.01242 -0.07173 0.00833  524 LEU B C   
3395 O O   . LEU B 2   ? 0.62806 0.61886 0.38678 -0.03580 -0.05300 -0.01956 524 LEU B O   
3396 C CB  . LEU B 2   ? 0.71826 0.77278 0.53734 0.02096  -0.13189 0.00160  524 LEU B CB  
3397 C CG  . LEU B 2   ? 0.66504 0.69618 0.51710 0.03073  -0.11843 0.02739  524 LEU B CG  
3398 C CD1 . LEU B 2   ? 0.70553 0.69542 0.49266 0.05604  -0.13234 0.05949  524 LEU B CD1 
3399 C CD2 . LEU B 2   ? 0.53597 0.61652 0.47551 0.03580  -0.13166 0.01506  524 LEU B CD2 
3412 N N   . ASP B 3   ? 0.57008 0.49511 0.27255 -0.00715 -0.05152 0.03577  525 ASP B N   
3413 C CA  . ASP B 3   ? 0.46110 0.36031 0.18038 -0.02924 -0.00777 0.02856  525 ASP B CA  
3414 C C   . ASP B 3   ? 0.38093 0.31384 0.19736 -0.02864 -0.00313 0.01972  525 ASP B C   
3415 O O   . ASP B 3   ? 0.34078 0.27485 0.18795 -0.01312 -0.00823 0.03645  525 ASP B O   
3416 C CB  . ASP B 3   ? 0.51364 0.35060 0.17753 -0.02757 0.01784  0.05350  525 ASP B CB  
3417 C CG  . ASP B 3   ? 0.56953 0.38898 0.25869 -0.05210 0.06432  0.03570  525 ASP B CG  
3418 O OD1 . ASP B 3   ? 0.46897 0.32541 0.22423 -0.06365 0.07184  0.00872  525 ASP B OD1 
3419 O OD2 . ASP B 3   ? 0.63854 0.40738 0.28561 -0.05838 0.09372  0.04660  525 ASP B OD2 
3424 N N   . LEU B 4   ? 0.33375 0.29273 0.19710 -0.04437 0.00722  -0.00647 526 LEU B N   
3425 C CA  . LEU B 4   ? 0.24588 0.23283 0.19011 -0.04023 0.00951  -0.01071 526 LEU B CA  
3426 C C   . LEU B 4   ? 0.22940 0.20248 0.19596 -0.03671 0.03186  -0.00347 526 LEU B C   
3427 O O   . LEU B 4   ? 0.19227 0.18831 0.21354 -0.02622 0.02888  0.00073  526 LEU B O   
3428 C CB  . LEU B 4   ? 0.24360 0.24933 0.22584 -0.05571 0.01855  -0.03798 526 LEU B CB  
3429 C CG  . LEU B 4   ? 0.23721 0.27180 0.22897 -0.06041 -0.00150 -0.05435 526 LEU B CG  
3430 C CD1 . LEU B 4   ? 0.26394 0.30504 0.29153 -0.07935 0.01726  -0.08433 526 LEU B CD1 
3431 C CD2 . LEU B 4   ? 0.30454 0.36650 0.34254 -0.04637 -0.02107 -0.04453 526 LEU B CD2 
3443 N N   . GLU B 5   ? 0.26069 0.19922 0.18691 -0.04573 0.05586  -0.00435 527 GLU B N   
3444 C CA  . GLU B 5   ? 0.26408 0.19804 0.22061 -0.04263 0.07712  -0.00499 527 GLU B CA  
3445 C C   . GLU B 5   ? 0.23795 0.17700 0.20864 -0.02329 0.06208  0.01773  527 GLU B C   
3446 O O   . GLU B 5   ? 0.24534 0.20186 0.26183 -0.01664 0.07114  0.01390  527 GLU B O   
3447 C CB  . GLU B 5   ? 0.34262 0.23862 0.26297 -0.06059 0.11383  -0.01745 527 GLU B CB  
3448 C CG  . GLU B 5   ? 0.40649 0.31626 0.35800 -0.07461 0.12832  -0.05263 527 GLU B CG  
3449 C CD  . GLU B 5   ? 0.57193 0.45809 0.52687 -0.08466 0.14325  -0.07131 527 GLU B CD  
3450 O OE1 . GLU B 5   ? 0.49142 0.34077 0.40270 -0.08844 0.15693  -0.06221 527 GLU B OE1 
3451 O OE2 . GLU B 5   ? 0.51077 0.42573 0.51307 -0.08590 0.13705  -0.08599 527 GLU B OE2 
3458 N N   . THR B 6   ? 0.25040 0.18075 0.18669 -0.01205 0.03680  0.03779  528 THR B N   
3459 C CA  . THR B 6   ? 0.24535 0.18135 0.20183 0.00725  0.02243  0.05594  528 THR B CA  
3460 C C   . THR B 6   ? 0.17462 0.16166 0.19851 0.01594  0.00578  0.05143  528 THR B C   
3461 O O   . THR B 6   ? 0.20048 0.20110 0.25363 0.02934  -0.00201 0.06014  528 THR B O   
3462 C CB  . THR B 6   ? 0.28977 0.20134 0.19189 0.02227  -0.00230 0.07750  528 THR B CB  
3463 O OG1 . THR B 6   ? 0.30915 0.25356 0.21124 0.02519  -0.03267 0.07003  528 THR B OG1 
3464 C CG2 . THR B 6   ? 0.37566 0.22515 0.19706 0.01547  0.01806  0.08927  528 THR B CG2 
3472 N N   . LEU B 7   ? 0.16649 0.17789 0.21462 0.00758  0.00384  0.03766  529 LEU B N   
3473 C CA  . LEU B 7   ? 0.13712 0.18624 0.24062 0.01324  -0.00439 0.03597  529 LEU B CA  
3474 C C   . LEU B 7   ? 0.13830 0.19326 0.26615 0.01006  0.01401  0.02596  529 LEU B C   
3475 O O   . LEU B 7   ? 0.14683 0.19862 0.26138 0.01059  0.00845  0.02143  529 LEU B O   
3476 C CB  . LEU B 7   ? 0.14107 0.20734 0.25176 0.00810  -0.02140 0.02818  529 LEU B CB  
3477 C CG  . LEU B 7   ? 0.14251 0.20926 0.22063 0.01394  -0.04742 0.02989  529 LEU B CG  
3478 C CD1 . LEU B 7   ? 0.17225 0.26865 0.27422 0.00539  -0.06001 0.01019  529 LEU B CD1 
3479 C CD2 . LEU B 7   ? 0.16749 0.24267 0.25757 0.03248  -0.06346 0.04375  529 LEU B CD2 
3491 N N   . ALA B 8   ? 0.19384 0.15108 0.15068 0.00805  0.02266  0.01236  530 ALA B N   
3492 C CA  . ALA B 8   ? 0.20053 0.16510 0.16170 0.01123  0.02175  0.00729  530 ALA B CA  
3493 C C   . ALA B 8   ? 0.20023 0.15303 0.16484 0.01133  0.01168  0.00431  530 ALA B C   
3494 O O   . ALA B 8   ? 0.21817 0.16333 0.19191 0.00500  0.00186  0.00855  530 ALA B O   
3495 C CB  . ALA B 8   ? 0.20531 0.19551 0.17539 0.00929  0.02568  0.01099  530 ALA B CB  
3501 N N   . HYP B 9   ? 0.21527 0.16666 0.17539 0.01945  0.01053  -0.00255 531 HYP B N   
3502 C CA  . HYP B 9   ? 0.21086 0.15137 0.17079 0.02519  -0.00219 -0.00949 531 HYP B CA  
3503 C C   . HYP B 9   ? 0.20215 0.14469 0.18206 0.01452  -0.01144 -0.00619 531 HYP B C   
3504 O O   . HYP B 9   ? 0.20764 0.16869 0.19632 0.00928  -0.00389 -0.00161 531 HYP B O   
3505 C CB  . HYP B 9   ? 0.21602 0.16420 0.16797 0.03727  0.00103  -0.01401 531 HYP B CB  
3506 C CG  . HYP B 9   ? 0.21505 0.17516 0.17215 0.03281  0.01164  -0.00855 531 HYP B CG  
3507 C CD  . HYP B 9   ? 0.22175 0.18076 0.17929 0.02575  0.01625  -0.00400 531 HYP B CD  
3508 O OD1 . HYP B 9   ? 0.23228 0.20011 0.18714 0.04162  0.01372  -0.00383 531 HYP B OD1 
3513 N N   . TYR B 10  ? 0.21163 0.13702 0.20069 0.01286  -0.03006 -0.00749 532 TYR B N   
3514 C CA  . TYR B 10  ? 0.20707 0.13344 0.22422 0.00043  -0.04487 0.00161  532 TYR B CA  
3515 C C   . TYR B 10  ? 0.21228 0.14520 0.23426 0.00292  -0.04659 -0.00326 532 TYR B C   
3516 O O   . TYR B 10  ? 0.23243 0.15732 0.23661 0.01819  -0.04769 -0.01908 532 TYR B O   
3517 C CB  . TYR B 10  ? 0.23177 0.12791 0.25967 0.00238  -0.07456 -0.00376 532 TYR B CB  
3518 C CG  . TYR B 10  ? 0.24462 0.13614 0.31178 -0.01257 -0.09919 0.00969  532 TYR B CG  
3519 C CD1 . TYR B 10  ? 0.24771 0.15703 0.34952 -0.03427 -0.10220 0.03920  532 TYR B CD1 
3520 C CD2 . TYR B 10  ? 0.29289 0.16635 0.36649 -0.00460 -0.12161 -0.00359 532 TYR B CD2 
3521 C CE1 . TYR B 10  ? 0.25125 0.16262 0.39767 -0.05019 -0.12682 0.05972  532 TYR B CE1 
3522 C CE2 . TYR B 10  ? 0.29842 0.16540 0.41503 -0.01998 -0.14938 0.01167  532 TYR B CE2 
3523 C CZ  . TYR B 10  ? 0.27083 0.15708 0.42624 -0.04399 -0.15248 0.04538  532 TYR B CZ  
3524 O OH  . TYR B 10  ? 0.32703 0.21791 0.52842 -0.05717 -0.17916 0.06699  532 TYR B OH  
3534 N N   . ILE B 11  ? 0.20196 0.15579 0.24906 -0.01096 -0.04625 0.01320  533 ILE B N   
3535 C CA  . ILE B 11  ? 0.22115 0.17850 0.28099 -0.01179 -0.05426 0.01178  533 ILE B CA  
3536 C C   . ILE B 11  ? 0.21994 0.18444 0.32138 -0.02956 -0.07374 0.03500  533 ILE B C   
3537 O O   . ILE B 11  ? 0.20614 0.19246 0.32800 -0.04258 -0.07127 0.05917  533 ILE B O   
3538 C CB  . ILE B 11  ? 0.18862 0.17539 0.23941 -0.00879 -0.03203 0.01174  533 ILE B CB  
3539 C CG1 . ILE B 11  ? 0.18071 0.20521 0.24065 -0.01593 -0.01731 0.03070  533 ILE B CG1 
3540 C CG2 . ILE B 11  ? 0.20622 0.18484 0.22745 0.00595  -0.01977 -0.00581 533 ILE B CG2 
3541 C CD1 . ILE B 11  ? 0.17932 0.23859 0.23906 -0.01105 -0.00445 0.03236  533 ILE B CD1 
3553 N N   . PRO B 12  ? 0.25143 0.20115 0.37055 -0.03058 -0.09561 0.03159  534 PRO B N   
3554 C CA  . PRO B 12  ? 0.28072 0.24003 0.45003 -0.05047 -0.11858 0.06039  534 PRO B CA  
3555 C C   . PRO B 12  ? 0.25807 0.27579 0.44474 -0.06219 -0.09560 0.09152  534 PRO B C   
3556 O O   . PRO B 12  ? 0.22834 0.27070 0.39559 -0.05380 -0.07315 0.08451  534 PRO B O   
3557 C CB  . PRO B 12  ? 0.35067 0.28597 0.52924 -0.04535 -0.14234 0.04626  534 PRO B CB  
3558 C CG  . PRO B 12  ? 0.34262 0.24821 0.47607 -0.01996 -0.14000 0.00829  534 PRO B CG  
3559 C CD  . PRO B 12  ? 0.33292 0.25915 0.43069 -0.01294 -0.10325 0.00403  534 PRO B CD  
3567 N N   . MET B 13  ? 0.31912 0.36374 0.54470 -0.07951 -0.10360 0.12771  535 MET B N   
3568 C CA  . MET B 13  ? 0.25742 0.37148 0.50073 -0.08540 -0.08294 0.16101  535 MET B CA  
3569 C C   . MET B 13  ? 0.38000 0.51049 0.65947 -0.09444 -0.09960 0.18958  535 MET B C   
3570 O O   . MET B 13  ? 0.38937 0.57289 0.66852 -0.09044 -0.08087 0.20787  535 MET B O   
3571 C CB  . MET B 13  ? 0.33514 0.48238 0.58261 -0.08820 -0.07209 0.18582  535 MET B CB  
3572 C CG  . MET B 13  ? 0.25711 0.39649 0.46089 -0.07488 -0.04917 0.16074  535 MET B CG  
3573 S SD  . MET B 13  ? 0.37067 0.52786 0.52275 -0.04965 -0.01725 0.12917  535 MET B SD  
3574 C CE  . MET B 13  ? 0.37848 0.62980 0.54621 -0.04414 0.00175  0.16528  535 MET B CE  
3584 N N   . ASP B 14  ? 0.38778 0.46886 0.68957 -0.10010 -0.13519 0.19017  536 ASP B N   
3585 C CA  . ASP B 14  ? 0.51871 0.59700 0.85426 -0.10666 -0.15879 0.21614  536 ASP B CA  
3586 C C   . ASP B 14  ? 0.33606 0.38511 0.66410 -0.10165 -0.16689 0.18751  536 ASP B C   
3587 O O   . ASP B 14  ? 0.68191 0.72315 0.98015 -0.09292 -0.15262 0.15237  536 ASP B O   
3588 C CB  . ASP B 14  ? 0.44605 0.48604 0.81078 -0.11027 -0.19704 0.23075  536 ASP B CB  
3591 N N   . GLY B 15  ? 0.52940 0.56299 0.88590 -0.10596 -0.19198 0.20381  537 GLY B N   
3592 C CA  . GLY B 15  ? 0.45952 0.47668 0.80722 -0.10026 -0.19465 0.17950  537 GLY B CA  
3593 C C   . GLY B 15  ? 0.46668 0.54528 0.80275 -0.10101 -0.15835 0.18671  537 GLY B C   
3594 O O   . GLY B 15  ? 0.63434 0.76901 0.97100 -0.10342 -0.13469 0.21471  537 GLY B O   
3598 N N   . GLU B 16  ? 0.62745 0.69737 0.94909 -0.09364 -0.15505 0.15908  538 GLU B N   
3599 C CA  . GLU B 16  ? 0.53066 0.65700 0.84092 -0.08930 -0.12409 0.16185  538 GLU B CA  
3600 C C   . GLU B 16  ? 0.44653 0.58497 0.71420 -0.07382 -0.09504 0.13374  538 GLU B C   
3601 O O   . GLU B 16  ? 0.82575 1.01468 1.08228 -0.06819 -0.06884 0.14644  538 GLU B O   
3602 C CB  . GLU B 16  ? 0.52993 0.63956 0.83651 -0.08388 -0.13123 0.14001  538 GLU B CB  
3605 N N   . ASP B 17  ? 0.60345 0.68887 0.83401 -0.05988 -0.09766 0.09287  539 ASP B N   
3606 C CA  . ASP B 17  ? 0.36744 0.44909 0.54801 -0.04049 -0.07098 0.06200  539 ASP B CA  
3607 C C   . ASP B 17  ? 0.25049 0.32637 0.42394 -0.03342 -0.07144 0.04641  539 ASP B C   
3608 O O   . ASP B 17  ? 0.32481 0.42217 0.52828 -0.04283 -0.07977 0.06517  539 ASP B O   
3609 C CB  . ASP B 17  ? 0.22865 0.36054 0.39494 -0.03389 -0.04197 0.07082  539 ASP B CB  
3610 C CG  . ASP B 17  ? 0.24420 0.39238 0.41248 -0.03737 -0.03578 0.08618  539 ASP B CG  
3611 O OD1 . ASP B 17  ? 0.21733 0.32790 0.38186 -0.04080 -0.04669 0.07896  539 ASP B OD1 
3612 O OD2 . ASP B 17  ? 0.18790 0.39031 0.35635 -0.03200 -0.01857 0.10229  539 ASP B OD2 
3617 N N   . PHE B 18  ? 0.22047 0.27509 0.35770 -0.01751 -0.06130 0.01705  540 PHE B N   
3618 C CA  . PHE B 18  ? 0.17535 0.22693 0.30535 -0.01010 -0.06065 0.00317  540 PHE B CA  
3619 C C   . PHE B 18  ? 0.15641 0.24815 0.28066 -0.00637 -0.03888 0.00782  540 PHE B C   
3620 O O   . PHE B 18  ? 0.16210 0.26777 0.26774 0.00129  -0.02251 0.00366  540 PHE B O   
3621 C CB  . PHE B 18  ? 0.19176 0.21376 0.28927 0.00656  -0.05892 -0.02409 540 PHE B CB  
3622 C CG  . PHE B 18  ? 0.19970 0.21945 0.29015 0.01516  -0.05929 -0.03697 540 PHE B CG  
3623 C CD1 . PHE B 18  ? 0.26583 0.26478 0.36655 0.01779  -0.08241 -0.04450 540 PHE B CD1 
3624 C CD2 . PHE B 18  ? 0.21093 0.24810 0.28742 0.02149  -0.04070 -0.04200 540 PHE B CD2 
3625 C CE1 . PHE B 18  ? 0.29154 0.29071 0.38504 0.02705  -0.08261 -0.05647 540 PHE B CE1 
3626 C CE2 . PHE B 18  ? 0.22316 0.25935 0.29561 0.02872  -0.04179 -0.05203 540 PHE B CE2 
3627 C CZ  . PHE B 18  ? 0.30123 0.32059 0.38091 0.03136  -0.06061 -0.05861 540 PHE B CZ  
3637 N N   . GLN B 19  ? 0.15665 0.26700 0.29761 -0.00968 -0.04178 0.01531  541 GLN B N   
3638 C CA  . GLN B 19  ? 0.15834 0.31045 0.29374 -0.00206 -0.02429 0.01817  541 GLN B CA  
3639 C C   . GLN B 19  ? 0.16378 0.29803 0.27759 0.00988  -0.02008 -0.00691 541 GLN B C   
3640 O O   . GLN B 19  ? 0.14493 0.25618 0.26295 0.00816  -0.03124 -0.01450 541 GLN B O   
3641 C CB  . GLN B 19  ? 0.16927 0.36501 0.33917 -0.01208 -0.02834 0.04768  541 GLN B CB  
3642 C CG  . GLN B 19  ? 0.21840 0.44173 0.42104 -0.02664 -0.03516 0.08290  541 GLN B CG  
3643 C CD  . GLN B 19  ? 0.26835 0.52254 0.45519 -0.01779 -0.01806 0.08795  541 GLN B CD  
3644 O OE1 . GLN B 19  ? 0.34128 0.64182 0.51330 -0.00149 -0.00102 0.08748  541 GLN B OE1 
3645 N NE2 . GLN B 19  ? 0.30765 0.53606 0.49585 -0.02526 -0.02472 0.09010  541 GLN B NE2 
3654 N N   . LEU B 20  ? 0.16327 0.30915 0.25681 0.02313  -0.00726 -0.01904 542 LEU B N   
3655 C CA  . LEU B 20  ? 0.16743 0.29686 0.24604 0.03328  -0.00599 -0.03892 542 LEU B CA  
3656 C C   . LEU B 20  ? 0.17893 0.33189 0.26465 0.03717  -0.00476 -0.03924 542 LEU B C   
3657 O O   . LEU B 20  ? 0.19662 0.33271 0.27641 0.04176  -0.00717 -0.05236 542 LEU B O   
3658 C CB  . LEU B 20  ? 0.18974 0.31600 0.25133 0.04523  -0.00100 -0.05099 542 LEU B CB  
3659 C CG  . LEU B 20  ? 0.22213 0.32413 0.27556 0.04228  -0.00157 -0.05104 542 LEU B CG  
3660 C CD1 . LEU B 20  ? 0.26615 0.36679 0.30951 0.05317  -0.00089 -0.06040 542 LEU B CD1 
3661 C CD2 . LEU B 20  ? 0.26829 0.34213 0.31853 0.04027  -0.00698 -0.05498 542 LEU B CD2 
3662 O OXT . LEU B 20  ? 0.17064 0.36369 0.26867 0.03697  -0.00117 -0.02454 542 LEU B OXT 
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