data_8RUZ
# 
_entry.id   8RUZ 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8RUZ         pdb_00008ruz 10.2210/pdb8ruz/pdb 
WWPDB D_1292136289 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-02-12 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8RUZ 
_pdbx_database_status.recvd_initial_deposition_date   2024-01-31 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              christopher.schofield@chem.ox.ac.uk 
_pdbx_contact_author.name_first         Christopher 
_pdbx_contact_author.name_last          Schofield 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-0290-6565 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Fiorini, G.'     1 0000-0003-3885-4629 
'Schofield, C.J.' 2 0000-0002-0290-6565 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Investigating gatekeeper residues in Prolyl hydroxyalse 2' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Fiorini, G.'     1 ? 
primary 'Schofield, C.J.' 2 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Egl nine homolog 1'              25450.930 1  1.14.11.29 ? ? ? 
2 polymer     syn 'Hypoxia-inducible Factor-2alpha' 2180.430  1  ?          ? ? ? 
3 non-polymer syn 'ACETATE ION'                     59.044    1  ?          ? ? ? 
4 water       nat water                             18.015    87 ?          ? ? ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
1 
;Hypoxia-inducible factor prolyl hydroxylase 2,HIF-PH2,HIF-prolyl hydroxylase 2,HPH-2,Prolyl hydroxylase domain-containing protein 2,PHD2,SM-20
;
2 
;EPAS-1,Basic-helix-loop-helix-PAS protein MOP2,Class E basic helix-loop-helix protein 73,bHLHe73,HIF-1-alpha-like factor,HLF,Hypoxia-inducible factor 2-alpha,HIF-2-alpha,HIF2-alpha,Member of PAS protein 2,PAS domain-containing protein 2
;
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;PNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIE
GKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSG
GILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAISVWYFDADERARAKVKYLTGE
;
;PNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIE
GKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSG
GILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAISVWYFDADERARAKVKYLTGE
;
A ? 
2 'polypeptide(L)' no no LDLETLAPYIPMDGEDFQL LDLETLAPYIPMDGEDFQL B ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 'ACETATE ION' ACT 
4 water         HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   PRO n 
1 2   ASN n 
1 3   GLY n 
1 4   GLN n 
1 5   THR n 
1 6   LYS n 
1 7   PRO n 
1 8   LEU n 
1 9   PRO n 
1 10  ALA n 
1 11  LEU n 
1 12  LYS n 
1 13  LEU n 
1 14  ALA n 
1 15  LEU n 
1 16  GLU n 
1 17  TYR n 
1 18  ILE n 
1 19  VAL n 
1 20  PRO n 
1 21  CYS n 
1 22  MET n 
1 23  ASN n 
1 24  LYS n 
1 25  HIS n 
1 26  GLY n 
1 27  ILE n 
1 28  CYS n 
1 29  VAL n 
1 30  VAL n 
1 31  ASP n 
1 32  ASP n 
1 33  PHE n 
1 34  LEU n 
1 35  GLY n 
1 36  LYS n 
1 37  GLU n 
1 38  THR n 
1 39  GLY n 
1 40  GLN n 
1 41  GLN n 
1 42  ILE n 
1 43  GLY n 
1 44  ASP n 
1 45  GLU n 
1 46  VAL n 
1 47  ARG n 
1 48  ALA n 
1 49  LEU n 
1 50  HIS n 
1 51  ASP n 
1 52  THR n 
1 53  GLY n 
1 54  LYS n 
1 55  PHE n 
1 56  THR n 
1 57  ASP n 
1 58  GLY n 
1 59  GLN n 
1 60  LEU n 
1 61  VAL n 
1 62  SER n 
1 63  GLN n 
1 64  LYS n 
1 65  SER n 
1 66  ASP n 
1 67  SER n 
1 68  SER n 
1 69  LYS n 
1 70  ASP n 
1 71  ILE n 
1 72  ARG n 
1 73  GLY n 
1 74  ASP n 
1 75  LYS n 
1 76  ILE n 
1 77  THR n 
1 78  TRP n 
1 79  ILE n 
1 80  GLU n 
1 81  GLY n 
1 82  LYS n 
1 83  GLU n 
1 84  PRO n 
1 85  GLY n 
1 86  CYS n 
1 87  GLU n 
1 88  THR n 
1 89  ILE n 
1 90  GLY n 
1 91  LEU n 
1 92  LEU n 
1 93  MET n 
1 94  SER n 
1 95  SER n 
1 96  MET n 
1 97  ASP n 
1 98  ASP n 
1 99  LEU n 
1 100 ILE n 
1 101 ARG n 
1 102 HIS n 
1 103 CYS n 
1 104 ASN n 
1 105 GLY n 
1 106 LYS n 
1 107 LEU n 
1 108 GLY n 
1 109 SER n 
1 110 TYR n 
1 111 LYS n 
1 112 ILE n 
1 113 ASN n 
1 114 GLY n 
1 115 ARG n 
1 116 THR n 
1 117 LYS n 
1 118 ALA n 
1 119 MET n 
1 120 VAL n 
1 121 ALA n 
1 122 CYS n 
1 123 TYR n 
1 124 PRO n 
1 125 GLY n 
1 126 ASN n 
1 127 GLY n 
1 128 THR n 
1 129 GLY n 
1 130 TYR n 
1 131 VAL n 
1 132 ARG n 
1 133 HIS n 
1 134 VAL n 
1 135 ASP n 
1 136 ASN n 
1 137 PRO n 
1 138 ASN n 
1 139 GLY n 
1 140 ASP n 
1 141 GLY n 
1 142 ARG n 
1 143 CYS n 
1 144 VAL n 
1 145 THR n 
1 146 CYS n 
1 147 ILE n 
1 148 TYR n 
1 149 TYR n 
1 150 LEU n 
1 151 ASN n 
1 152 LYS n 
1 153 ASP n 
1 154 TRP n 
1 155 ASP n 
1 156 ALA n 
1 157 LYS n 
1 158 VAL n 
1 159 SER n 
1 160 GLY n 
1 161 GLY n 
1 162 ILE n 
1 163 LEU n 
1 164 ARG n 
1 165 ILE n 
1 166 PHE n 
1 167 PRO n 
1 168 GLU n 
1 169 GLY n 
1 170 LYS n 
1 171 ALA n 
1 172 GLN n 
1 173 PHE n 
1 174 ALA n 
1 175 ASP n 
1 176 ILE n 
1 177 GLU n 
1 178 PRO n 
1 179 LYS n 
1 180 PHE n 
1 181 ASP n 
1 182 ARG n 
1 183 LEU n 
1 184 LEU n 
1 185 PHE n 
1 186 PHE n 
1 187 TRP n 
1 188 SER n 
1 189 ASP n 
1 190 ARG n 
1 191 ARG n 
1 192 ASN n 
1 193 PRO n 
1 194 HIS n 
1 195 GLU n 
1 196 VAL n 
1 197 GLN n 
1 198 PRO n 
1 199 ALA n 
1 200 TYR n 
1 201 ALA n 
1 202 THR n 
1 203 ARG n 
1 204 TYR n 
1 205 ALA n 
1 206 ILE n 
1 207 SER n 
1 208 VAL n 
1 209 TRP n 
1 210 TYR n 
1 211 PHE n 
1 212 ASP n 
1 213 ALA n 
1 214 ASP n 
1 215 GLU n 
1 216 ARG n 
1 217 ALA n 
1 218 ARG n 
1 219 ALA n 
1 220 LYS n 
1 221 VAL n 
1 222 LYS n 
1 223 TYR n 
1 224 LEU n 
1 225 THR n 
1 226 GLY n 
1 227 GLU n 
2 1   LEU n 
2 2   ASP n 
2 3   LEU n 
2 4   GLU n 
2 5   THR n 
2 6   LEU n 
2 7   ALA n 
2 8   PRO n 
2 9   TYR n 
2 10  ILE n 
2 11  PRO n 
2 12  MET n 
2 13  ASP n 
2 14  GLY n 
2 15  GLU n 
2 16  ASP n 
2 17  PHE n 
2 18  GLN n 
2 19  LEU n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   227 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'EGLN1, C1orf12, PNAS-118, PNAS-137' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
_pdbx_entity_src_syn.entity_id              2 
_pdbx_entity_src_syn.pdbx_src_id            1 
_pdbx_entity_src_syn.pdbx_alt_source_flag   sample 
_pdbx_entity_src_syn.pdbx_beg_seq_num       1 
_pdbx_entity_src_syn.pdbx_end_seq_num       19 
_pdbx_entity_src_syn.organism_scientific    'Homo sapiens' 
_pdbx_entity_src_syn.organism_common_name   human 
_pdbx_entity_src_syn.ncbi_taxonomy_id       9606 
_pdbx_entity_src_syn.details                ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ACT non-polymer         . 'ACETATE ION'   ? 'C2 H3 O2 -1'    59.044  
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   PRO 1   181 ?   ?   ?   A . n 
A 1 2   ASN 2   182 ?   ?   ?   A . n 
A 1 3   GLY 3   183 ?   ?   ?   A . n 
A 1 4   GLN 4   184 ?   ?   ?   A . n 
A 1 5   THR 5   185 ?   ?   ?   A . n 
A 1 6   LYS 6   186 ?   ?   ?   A . n 
A 1 7   PRO 7   187 ?   ?   ?   A . n 
A 1 8   LEU 8   188 188 LEU LEU A . n 
A 1 9   PRO 9   189 189 PRO PRO A . n 
A 1 10  ALA 10  190 190 ALA ALA A . n 
A 1 11  LEU 11  191 191 LEU LEU A . n 
A 1 12  LYS 12  192 192 LYS LYS A . n 
A 1 13  LEU 13  193 193 LEU LEU A . n 
A 1 14  ALA 14  194 194 ALA ALA A . n 
A 1 15  LEU 15  195 195 LEU LEU A . n 
A 1 16  GLU 16  196 196 GLU GLU A . n 
A 1 17  TYR 17  197 197 TYR TYR A . n 
A 1 18  ILE 18  198 198 ILE ILE A . n 
A 1 19  VAL 19  199 199 VAL VAL A . n 
A 1 20  PRO 20  200 200 PRO PRO A . n 
A 1 21  CYS 21  201 201 CYS CYS A . n 
A 1 22  MET 22  202 202 MET MET A . n 
A 1 23  ASN 23  203 203 ASN ASN A . n 
A 1 24  LYS 24  204 204 LYS LYS A . n 
A 1 25  HIS 25  205 205 HIS HIS A . n 
A 1 26  GLY 26  206 206 GLY GLY A . n 
A 1 27  ILE 27  207 207 ILE ILE A . n 
A 1 28  CYS 28  208 208 CYS CYS A . n 
A 1 29  VAL 29  209 209 VAL VAL A . n 
A 1 30  VAL 30  210 210 VAL VAL A . n 
A 1 31  ASP 31  211 211 ASP ASP A . n 
A 1 32  ASP 32  212 212 ASP ASP A . n 
A 1 33  PHE 33  213 213 PHE PHE A . n 
A 1 34  LEU 34  214 214 LEU LEU A . n 
A 1 35  GLY 35  215 215 GLY GLY A . n 
A 1 36  LYS 36  216 216 LYS LYS A . n 
A 1 37  GLU 37  217 217 GLU GLU A . n 
A 1 38  THR 38  218 218 THR THR A . n 
A 1 39  GLY 39  219 219 GLY GLY A . n 
A 1 40  GLN 40  220 220 GLN GLN A . n 
A 1 41  GLN 41  221 221 GLN GLN A . n 
A 1 42  ILE 42  222 222 ILE ILE A . n 
A 1 43  GLY 43  223 223 GLY GLY A . n 
A 1 44  ASP 44  224 224 ASP ASP A . n 
A 1 45  GLU 45  225 225 GLU GLU A . n 
A 1 46  VAL 46  226 226 VAL VAL A . n 
A 1 47  ARG 47  227 227 ARG ARG A . n 
A 1 48  ALA 48  228 228 ALA ALA A . n 
A 1 49  LEU 49  229 229 LEU LEU A . n 
A 1 50  HIS 50  230 230 HIS HIS A . n 
A 1 51  ASP 51  231 231 ASP ASP A . n 
A 1 52  THR 52  232 232 THR THR A . n 
A 1 53  GLY 53  233 233 GLY GLY A . n 
A 1 54  LYS 54  234 234 LYS LYS A . n 
A 1 55  PHE 55  235 235 PHE PHE A . n 
A 1 56  THR 56  236 236 THR THR A . n 
A 1 57  ASP 57  237 237 ASP ASP A . n 
A 1 58  GLY 58  238 238 GLY GLY A . n 
A 1 59  GLN 59  239 239 GLN GLN A . n 
A 1 60  LEU 60  240 240 LEU LEU A . n 
A 1 61  VAL 61  241 241 VAL VAL A . n 
A 1 62  SER 62  242 242 SER SER A . n 
A 1 63  GLN 63  243 243 GLN GLN A . n 
A 1 64  LYS 64  244 244 LYS LYS A . n 
A 1 65  SER 65  245 245 SER SER A . n 
A 1 66  ASP 66  246 246 ASP ASP A . n 
A 1 67  SER 67  247 247 SER SER A . n 
A 1 68  SER 68  248 248 SER SER A . n 
A 1 69  LYS 69  249 249 LYS LYS A . n 
A 1 70  ASP 70  250 250 ASP ASP A . n 
A 1 71  ILE 71  251 251 ILE ILE A . n 
A 1 72  ARG 72  252 252 ARG ARG A . n 
A 1 73  GLY 73  253 253 GLY GLY A . n 
A 1 74  ASP 74  254 254 ASP ASP A . n 
A 1 75  LYS 75  255 255 LYS LYS A . n 
A 1 76  ILE 76  256 256 ILE ILE A . n 
A 1 77  THR 77  257 257 THR THR A . n 
A 1 78  TRP 78  258 258 TRP TRP A . n 
A 1 79  ILE 79  259 259 ILE ILE A . n 
A 1 80  GLU 80  260 260 GLU GLU A . n 
A 1 81  GLY 81  261 261 GLY GLY A . n 
A 1 82  LYS 82  262 262 LYS LYS A . n 
A 1 83  GLU 83  263 263 GLU GLU A . n 
A 1 84  PRO 84  264 264 PRO PRO A . n 
A 1 85  GLY 85  265 265 GLY GLY A . n 
A 1 86  CYS 86  266 266 CYS CYS A . n 
A 1 87  GLU 87  267 267 GLU GLU A . n 
A 1 88  THR 88  268 268 THR THR A . n 
A 1 89  ILE 89  269 269 ILE ILE A . n 
A 1 90  GLY 90  270 270 GLY GLY A . n 
A 1 91  LEU 91  271 271 LEU LEU A . n 
A 1 92  LEU 92  272 272 LEU LEU A . n 
A 1 93  MET 93  273 273 MET MET A . n 
A 1 94  SER 94  274 274 SER SER A . n 
A 1 95  SER 95  275 275 SER SER A . n 
A 1 96  MET 96  276 276 MET MET A . n 
A 1 97  ASP 97  277 277 ASP ASP A . n 
A 1 98  ASP 98  278 278 ASP ASP A . n 
A 1 99  LEU 99  279 279 LEU LEU A . n 
A 1 100 ILE 100 280 280 ILE ILE A . n 
A 1 101 ARG 101 281 281 ARG ARG A . n 
A 1 102 HIS 102 282 282 HIS HIS A . n 
A 1 103 CYS 103 283 283 CYS CYS A . n 
A 1 104 ASN 104 284 284 ASN ASN A . n 
A 1 105 GLY 105 285 285 GLY GLY A . n 
A 1 106 LYS 106 286 286 LYS LYS A . n 
A 1 107 LEU 107 287 287 LEU LEU A . n 
A 1 108 GLY 108 288 288 GLY GLY A . n 
A 1 109 SER 109 289 289 SER SER A . n 
A 1 110 TYR 110 290 290 TYR TYR A . n 
A 1 111 LYS 111 291 291 LYS LYS A . n 
A 1 112 ILE 112 292 292 ILE ILE A . n 
A 1 113 ASN 113 293 293 ASN ASN A . n 
A 1 114 GLY 114 294 294 GLY GLY A . n 
A 1 115 ARG 115 295 295 ARG ARG A . n 
A 1 116 THR 116 296 296 THR THR A . n 
A 1 117 LYS 117 297 297 LYS LYS A . n 
A 1 118 ALA 118 298 298 ALA ALA A . n 
A 1 119 MET 119 299 299 MET MET A . n 
A 1 120 VAL 120 300 300 VAL VAL A . n 
A 1 121 ALA 121 301 301 ALA ALA A . n 
A 1 122 CYS 122 302 302 CYS CYS A . n 
A 1 123 TYR 123 303 303 TYR TYR A . n 
A 1 124 PRO 124 304 304 PRO PRO A . n 
A 1 125 GLY 125 305 305 GLY GLY A . n 
A 1 126 ASN 126 306 306 ASN ASN A . n 
A 1 127 GLY 127 307 307 GLY GLY A . n 
A 1 128 THR 128 308 308 THR THR A . n 
A 1 129 GLY 129 309 309 GLY GLY A . n 
A 1 130 TYR 130 310 310 TYR TYR A . n 
A 1 131 VAL 131 311 311 VAL VAL A . n 
A 1 132 ARG 132 312 312 ARG ARG A . n 
A 1 133 HIS 133 313 313 HIS HIS A . n 
A 1 134 VAL 134 314 314 VAL VAL A . n 
A 1 135 ASP 135 315 315 ASP ASP A . n 
A 1 136 ASN 136 316 316 ASN ASN A . n 
A 1 137 PRO 137 317 317 PRO PRO A . n 
A 1 138 ASN 138 318 318 ASN ASN A . n 
A 1 139 GLY 139 319 319 GLY GLY A . n 
A 1 140 ASP 140 320 320 ASP ASP A . n 
A 1 141 GLY 141 321 321 GLY GLY A . n 
A 1 142 ARG 142 322 322 ARG ARG A . n 
A 1 143 CYS 143 323 323 CYS CYS A . n 
A 1 144 VAL 144 324 324 VAL VAL A . n 
A 1 145 THR 145 325 325 THR THR A . n 
A 1 146 CYS 146 326 326 CYS CYS A . n 
A 1 147 ILE 147 327 327 ILE ILE A . n 
A 1 148 TYR 148 328 328 TYR TYR A . n 
A 1 149 TYR 149 329 329 TYR TYR A . n 
A 1 150 LEU 150 330 330 LEU LEU A . n 
A 1 151 ASN 151 331 331 ASN ASN A . n 
A 1 152 LYS 152 332 332 LYS LYS A . n 
A 1 153 ASP 153 333 333 ASP ASP A . n 
A 1 154 TRP 154 334 334 TRP TRP A . n 
A 1 155 ASP 155 335 335 ASP ASP A . n 
A 1 156 ALA 156 336 336 ALA ALA A . n 
A 1 157 LYS 157 337 337 LYS LYS A . n 
A 1 158 VAL 158 338 338 VAL VAL A . n 
A 1 159 SER 159 339 339 SER SER A . n 
A 1 160 GLY 160 340 340 GLY GLY A . n 
A 1 161 GLY 161 341 341 GLY GLY A . n 
A 1 162 ILE 162 342 342 ILE ILE A . n 
A 1 163 LEU 163 343 343 LEU LEU A . n 
A 1 164 ARG 164 344 344 ARG ARG A . n 
A 1 165 ILE 165 345 345 ILE ILE A . n 
A 1 166 PHE 166 346 346 PHE PHE A . n 
A 1 167 PRO 167 347 347 PRO PRO A . n 
A 1 168 GLU 168 348 348 GLU GLU A . n 
A 1 169 GLY 169 349 349 GLY GLY A . n 
A 1 170 LYS 170 350 350 LYS LYS A . n 
A 1 171 ALA 171 351 351 ALA ALA A . n 
A 1 172 GLN 172 352 352 GLN GLN A . n 
A 1 173 PHE 173 353 353 PHE PHE A . n 
A 1 174 ALA 174 354 354 ALA ALA A . n 
A 1 175 ASP 175 355 355 ASP ASP A . n 
A 1 176 ILE 176 356 356 ILE ILE A . n 
A 1 177 GLU 177 357 357 GLU GLU A . n 
A 1 178 PRO 178 358 358 PRO PRO A . n 
A 1 179 LYS 179 359 359 LYS LYS A . n 
A 1 180 PHE 180 360 360 PHE PHE A . n 
A 1 181 ASP 181 361 361 ASP ASP A . n 
A 1 182 ARG 182 362 362 ARG ARG A . n 
A 1 183 LEU 183 363 363 LEU LEU A . n 
A 1 184 LEU 184 364 364 LEU LEU A . n 
A 1 185 PHE 185 365 365 PHE PHE A . n 
A 1 186 PHE 186 366 366 PHE PHE A . n 
A 1 187 TRP 187 367 367 TRP TRP A . n 
A 1 188 SER 188 368 368 SER SER A . n 
A 1 189 ASP 189 369 369 ASP ASP A . n 
A 1 190 ARG 190 370 370 ARG ARG A . n 
A 1 191 ARG 191 371 371 ARG ARG A . n 
A 1 192 ASN 192 372 372 ASN ASN A . n 
A 1 193 PRO 193 373 373 PRO PRO A . n 
A 1 194 HIS 194 374 374 HIS HIS A . n 
A 1 195 GLU 195 375 375 GLU GLU A . n 
A 1 196 VAL 196 376 376 VAL VAL A . n 
A 1 197 GLN 197 377 377 GLN GLN A . n 
A 1 198 PRO 198 378 378 PRO PRO A . n 
A 1 199 ALA 199 379 379 ALA ALA A . n 
A 1 200 TYR 200 380 380 TYR TYR A . n 
A 1 201 ALA 201 381 381 ALA ALA A . n 
A 1 202 THR 202 382 382 THR THR A . n 
A 1 203 ARG 203 383 383 ARG ARG A . n 
A 1 204 TYR 204 384 384 TYR TYR A . n 
A 1 205 ALA 205 385 385 ALA ALA A . n 
A 1 206 ILE 206 386 386 ILE ILE A . n 
A 1 207 SER 207 387 387 SER SER A . n 
A 1 208 VAL 208 388 388 VAL VAL A . n 
A 1 209 TRP 209 389 389 TRP TRP A . n 
A 1 210 TYR 210 390 390 TYR TYR A . n 
A 1 211 PHE 211 391 391 PHE PHE A . n 
A 1 212 ASP 212 392 392 ASP ASP A . n 
A 1 213 ALA 213 393 393 ALA ALA A . n 
A 1 214 ASP 214 394 394 ASP ASP A . n 
A 1 215 GLU 215 395 395 GLU GLU A . n 
A 1 216 ARG 216 396 396 ARG ARG A . n 
A 1 217 ALA 217 397 397 ALA ALA A . n 
A 1 218 ARG 218 398 398 ARG ARG A . n 
A 1 219 ALA 219 399 399 ALA ALA A . n 
A 1 220 LYS 220 400 400 LYS LYS A . n 
A 1 221 VAL 221 401 401 VAL VAL A . n 
A 1 222 LYS 222 402 402 LYS LYS A . n 
A 1 223 TYR 223 403 403 TYR TYR A . n 
A 1 224 LEU 224 404 404 LEU LEU A . n 
A 1 225 THR 225 405 405 THR THR A . n 
A 1 226 GLY 226 406 406 GLY GLY A . n 
A 1 227 GLU 227 407 ?   ?   ?   A . n 
B 2 1   LEU 1   524 524 LEU LEU B . n 
B 2 2   ASP 2   525 525 ASP ASP B . n 
B 2 3   LEU 3   526 526 LEU LEU B . n 
B 2 4   GLU 4   527 527 GLU GLU B . n 
B 2 5   THR 5   528 528 THR THR B . n 
B 2 6   LEU 6   529 529 LEU LEU B . n 
B 2 7   ALA 7   530 530 ALA ALA B . n 
B 2 8   PRO 8   531 531 PRO PRO B . n 
B 2 9   TYR 9   532 532 TYR TYR B . n 
B 2 10  ILE 10  533 533 ILE ILE B . n 
B 2 11  PRO 11  534 534 PRO PRO B . n 
B 2 12  MET 12  535 535 MET MET B . n 
B 2 13  ASP 13  536 536 ASP ASP B . n 
B 2 14  GLY 14  537 537 GLY GLY B . n 
B 2 15  GLU 15  538 538 GLU GLU B . n 
B 2 16  ASP 16  539 539 ASP ASP B . n 
B 2 17  PHE 17  540 540 PHE PHE B . n 
B 2 18  GLN 18  541 541 GLN GLN B . n 
B 2 19  LEU 19  542 542 LEU LEU B . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 3 ACT 1  501 501 ACT ACT A . 
D 4 HOH 1  601 38  HOH HOH A . 
D 4 HOH 2  602 47  HOH HOH A . 
D 4 HOH 3  603 73  HOH HOH A . 
D 4 HOH 4  604 49  HOH HOH A . 
D 4 HOH 5  605 39  HOH HOH A . 
D 4 HOH 6  606 68  HOH HOH A . 
D 4 HOH 7  607 51  HOH HOH A . 
D 4 HOH 8  608 46  HOH HOH A . 
D 4 HOH 9  609 24  HOH HOH A . 
D 4 HOH 10 610 10  HOH HOH A . 
D 4 HOH 11 611 79  HOH HOH A . 
D 4 HOH 12 612 48  HOH HOH A . 
D 4 HOH 13 613 69  HOH HOH A . 
D 4 HOH 14 614 1   HOH HOH A . 
D 4 HOH 15 615 18  HOH HOH A . 
D 4 HOH 16 616 76  HOH HOH A . 
D 4 HOH 17 617 13  HOH HOH A . 
D 4 HOH 18 618 92  HOH HOH A . 
D 4 HOH 19 619 90  HOH HOH A . 
D 4 HOH 20 620 5   HOH HOH A . 
D 4 HOH 21 621 35  HOH HOH A . 
D 4 HOH 22 622 6   HOH HOH A . 
D 4 HOH 23 623 14  HOH HOH A . 
D 4 HOH 24 624 7   HOH HOH A . 
D 4 HOH 25 625 59  HOH HOH A . 
D 4 HOH 26 626 2   HOH HOH A . 
D 4 HOH 27 627 85  HOH HOH A . 
D 4 HOH 28 628 53  HOH HOH A . 
D 4 HOH 29 629 16  HOH HOH A . 
D 4 HOH 30 630 28  HOH HOH A . 
D 4 HOH 31 631 67  HOH HOH A . 
D 4 HOH 32 632 45  HOH HOH A . 
D 4 HOH 33 633 23  HOH HOH A . 
D 4 HOH 34 634 31  HOH HOH A . 
D 4 HOH 35 635 78  HOH HOH A . 
D 4 HOH 36 636 87  HOH HOH A . 
D 4 HOH 37 637 60  HOH HOH A . 
D 4 HOH 38 638 50  HOH HOH A . 
D 4 HOH 39 639 3   HOH HOH A . 
D 4 HOH 40 640 33  HOH HOH A . 
D 4 HOH 41 641 22  HOH HOH A . 
D 4 HOH 42 642 12  HOH HOH A . 
D 4 HOH 43 643 44  HOH HOH A . 
D 4 HOH 44 644 4   HOH HOH A . 
D 4 HOH 45 645 17  HOH HOH A . 
D 4 HOH 46 646 91  HOH HOH A . 
D 4 HOH 47 647 32  HOH HOH A . 
D 4 HOH 48 648 88  HOH HOH A . 
D 4 HOH 49 649 86  HOH HOH A . 
D 4 HOH 50 650 8   HOH HOH A . 
D 4 HOH 51 651 40  HOH HOH A . 
D 4 HOH 52 652 43  HOH HOH A . 
D 4 HOH 53 653 20  HOH HOH A . 
D 4 HOH 54 654 26  HOH HOH A . 
D 4 HOH 55 655 70  HOH HOH A . 
D 4 HOH 56 656 27  HOH HOH A . 
D 4 HOH 57 657 52  HOH HOH A . 
D 4 HOH 58 658 19  HOH HOH A . 
D 4 HOH 59 659 66  HOH HOH A . 
D 4 HOH 60 660 29  HOH HOH A . 
D 4 HOH 61 661 15  HOH HOH A . 
D 4 HOH 62 662 71  HOH HOH A . 
D 4 HOH 63 663 77  HOH HOH A . 
D 4 HOH 64 664 30  HOH HOH A . 
D 4 HOH 65 665 82  HOH HOH A . 
D 4 HOH 66 666 72  HOH HOH A . 
D 4 HOH 67 667 63  HOH HOH A . 
D 4 HOH 68 668 9   HOH HOH A . 
D 4 HOH 69 669 25  HOH HOH A . 
D 4 HOH 70 670 37  HOH HOH A . 
D 4 HOH 71 671 34  HOH HOH A . 
D 4 HOH 72 672 83  HOH HOH A . 
D 4 HOH 73 673 61  HOH HOH A . 
D 4 HOH 74 674 64  HOH HOH A . 
D 4 HOH 75 675 75  HOH HOH A . 
D 4 HOH 76 676 74  HOH HOH A . 
D 4 HOH 77 677 62  HOH HOH A . 
D 4 HOH 78 678 56  HOH HOH A . 
D 4 HOH 79 679 80  HOH HOH A . 
E 4 HOH 1  601 21  HOH HOH B . 
E 4 HOH 2  602 84  HOH HOH B . 
E 4 HOH 3  603 11  HOH HOH B . 
E 4 HOH 4  604 41  HOH HOH B . 
E 4 HOH 5  605 89  HOH HOH B . 
E 4 HOH 6  606 54  HOH HOH B . 
E 4 HOH 7  607 55  HOH HOH B . 
E 4 HOH 8  608 58  HOH HOH B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A LEU 188 ? CG  ? A LEU 8   CG  
2  1 Y 1 A LEU 188 ? CD1 ? A LEU 8   CD1 
3  1 Y 1 A LEU 188 ? CD2 ? A LEU 8   CD2 
4  1 Y 1 A LYS 192 ? CE  ? A LYS 12  CE  
5  1 Y 1 A LYS 192 ? NZ  ? A LYS 12  NZ  
6  1 Y 1 A LYS 216 ? CE  ? A LYS 36  CE  
7  1 Y 1 A LYS 216 ? NZ  ? A LYS 36  NZ  
8  1 Y 1 A GLU 217 ? CD  ? A GLU 37  CD  
9  1 Y 1 A GLU 217 ? OE1 ? A GLU 37  OE1 
10 1 Y 1 A GLU 217 ? OE2 ? A GLU 37  OE2 
11 1 Y 1 A GLN 220 ? CG  ? A GLN 40  CG  
12 1 Y 1 A GLN 220 ? CD  ? A GLN 40  CD  
13 1 Y 1 A GLN 220 ? OE1 ? A GLN 40  OE1 
14 1 Y 1 A GLN 220 ? NE2 ? A GLN 40  NE2 
15 1 Y 1 A LYS 244 ? CE  ? A LYS 64  CE  
16 1 Y 1 A LYS 244 ? NZ  ? A LYS 64  NZ  
17 1 Y 1 A LYS 249 ? NZ  ? A LYS 69  NZ  
18 1 Y 1 A GLU 260 ? CD  ? A GLU 80  CD  
19 1 Y 1 A GLU 260 ? OE1 ? A GLU 80  OE1 
20 1 Y 1 A GLU 260 ? OE2 ? A GLU 80  OE2 
21 1 Y 1 A LYS 262 ? NZ  ? A LYS 82  NZ  
22 1 Y 1 A ASN 284 ? CG  ? A ASN 104 CG  
23 1 Y 1 A ASN 284 ? OD1 ? A ASN 104 OD1 
24 1 Y 1 A ASN 284 ? ND2 ? A ASN 104 ND2 
25 1 Y 1 A LYS 332 ? CD  ? A LYS 152 CD  
26 1 Y 1 A LYS 332 ? CE  ? A LYS 152 CE  
27 1 Y 1 A LYS 332 ? NZ  ? A LYS 152 NZ  
28 1 Y 1 A LYS 337 ? CE  ? A LYS 157 CE  
29 1 Y 1 A LYS 337 ? NZ  ? A LYS 157 NZ  
30 1 Y 1 A GLU 348 ? CD  ? A GLU 168 CD  
31 1 Y 1 A GLU 348 ? OE1 ? A GLU 168 OE1 
32 1 Y 1 A GLU 348 ? OE2 ? A GLU 168 OE2 
33 1 Y 1 A LYS 359 ? NZ  ? A LYS 179 NZ  
34 1 Y 1 A LYS 402 ? CE  ? A LYS 222 CE  
35 1 Y 1 A LYS 402 ? NZ  ? A LYS 222 NZ  
36 1 Y 1 B LEU 524 ? CG  ? B LEU 1   CG  
37 1 Y 1 B LEU 524 ? CD1 ? B LEU 1   CD1 
38 1 Y 1 B LEU 524 ? CD2 ? B LEU 1   CD2 
39 1 Y 1 B ASP 536 ? CG  ? B ASP 13  CG  
40 1 Y 1 B ASP 536 ? OD1 ? B ASP 13  OD1 
41 1 Y 1 B ASP 536 ? OD2 ? B ASP 13  OD2 
42 1 Y 1 B GLU 538 ? CG  ? B GLU 15  CG  
43 1 Y 1 B GLU 538 ? CD  ? B GLU 15  CD  
44 1 Y 1 B GLU 538 ? OE1 ? B GLU 15  OE1 
45 1 Y 1 B GLU 538 ? OE2 ? B GLU 15  OE2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.19.2_4158 1 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.19.2_4158 2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? autoPROC ? ? ? .           3 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? autoPROC ? ? ? .           4 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER   ? ? ? .           5 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8RUZ 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     130.295 
_cell.length_a_esd                 ? 
_cell.length_b                     37.951 
_cell.length_b_esd                 ? 
_cell.length_c                     42.076 
_cell.length_c_esd                 ? 
_cell.volume                       208058.480 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8RUZ 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                18 
_symmetry.space_group_name_Hall            'P 2 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8RUZ 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             1.88 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          34.66 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
'(10-35%) PEG 4K, 0.2 M ammonium acetate and 0.1 M sodium ammonium acetate trihydrate pH (4.1-5.6).' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            297 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-01-24 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.9762 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'DIAMOND BEAMLINE I03' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.9762 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   I03 
_diffrn_source.pdbx_synchrotron_site       Diamond 
# 
_reflns.B_iso_Wilson_estimate                          22.30 
_reflns.entry_id                                       8RUZ 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.82 
_reflns.d_resolution_low                               42.08 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     19502 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                12.9 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          7.8 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   1 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.82 
_reflns_shell.d_res_low                                     1.85 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             935 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.4 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               31.56 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8RUZ 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.82 
_refine.ls_d_res_low                             42.08 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     19492 
_refine.ls_number_reflns_R_free                  952 
_refine.ls_number_reflns_R_work                  18540 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.95 
_refine.ls_percent_reflns_R_free                 4.88 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2658 
_refine.ls_R_factor_R_free                       0.3144 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2632 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 34.1419 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2904 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.82 
_refine_hist.d_res_low                        42.08 
_refine_hist.number_atoms_solvent             87 
_refine_hist.number_atoms_total               1925 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1834 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         4 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0018 ? 1907 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.5352 ? 2588 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0433 ? 276  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0034 ? 340  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 5.0616 ? 269  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.82 1.91  . . 141 2587 99.82  . . . . 0.3580 . . . . . . . . . . . 0.4019 
'X-RAY DIFFRACTION' 1.91 2.03  . . 138 2575 100.00 . . . . 0.3469 . . . . . . . . . . . 0.3860 
'X-RAY DIFFRACTION' 2.03 2.19  . . 114 2631 100.00 . . . . 0.3195 . . . . . . . . . . . 0.3460 
'X-RAY DIFFRACTION' 2.19 2.41  . . 129 2618 100.00 . . . . 0.3094 . . . . . . . . . . . 0.3357 
'X-RAY DIFFRACTION' 2.41 2.76  . . 139 2630 99.96  . . . . 0.2842 . . . . . . . . . . . 0.3334 
'X-RAY DIFFRACTION' 2.76 3.48  . . 139 2691 100.00 . . . . 0.2464 . . . . . . . . . . . 0.3389 
'X-RAY DIFFRACTION' 3.48 42.08 . . 152 2808 99.93  . . . . 0.2079 . . . . . . . . . . . 0.2520 
# 
_struct.entry_id                     8RUZ 
_struct.title                        
'Anaerobic HIF prolyl-hydroxylase-2 (PHD2) T387S variant bound to acetate (ACT) and Hypoxia-inducible Factor-2alpha (HIF-2alpha)' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8RUZ 
_struct_keywords.text            '2OG oxygenase, Oxygen sensing, Prolyl Hydroxylase, substrate complex, OXIDOREDUCTASE' 
_struct_keywords.pdbx_keywords   OXIDOREDUCTASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP EGLN1_HUMAN Q9GZT9 ? 1 
;PNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIE
GKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSG
GILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGE
;
0   
2 UNP EPAS1_HUMAN Q99814 ? 2 LDLETLAPYIPMDGEDFQL 524 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8RUZ A 1 ? 227 ? Q9GZT9 181 ? 407 ? 181 407 
2 2 8RUZ B 1 ? 19  ? Q99814 524 ? 542 ? 524 542 
# 
_struct_ref_seq_dif.align_id                     1 
_struct_ref_seq_dif.pdbx_pdb_id_code             8RUZ 
_struct_ref_seq_dif.mon_id                       SER 
_struct_ref_seq_dif.pdbx_pdb_strand_id           A 
_struct_ref_seq_dif.seq_num                      207 
_struct_ref_seq_dif.pdbx_pdb_ins_code            ? 
_struct_ref_seq_dif.pdbx_seq_db_name             UNP 
_struct_ref_seq_dif.pdbx_seq_db_accession_code   Q9GZT9 
_struct_ref_seq_dif.db_mon_id                    THR 
_struct_ref_seq_dif.pdbx_seq_db_seq_num          387 
_struct_ref_seq_dif.details                      'engineered mutation' 
_struct_ref_seq_dif.pdbx_auth_seq_num            387 
_struct_ref_seq_dif.pdbx_ordinal                 1 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 2650  ? 
1 MORE         -14   ? 
1 'SSA (A^2)'  10860 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 PRO A 9   ? TYR A 17  ? PRO A 189 TYR A 197 1 ? 9  
HELX_P HELX_P2 AA2 TYR A 17  ? GLY A 26  ? TYR A 197 GLY A 206 1 ? 10 
HELX_P HELX_P3 AA3 GLY A 35  ? THR A 52  ? GLY A 215 THR A 232 1 ? 18 
HELX_P HELX_P4 AA4 SER A 67  ? ILE A 71  ? SER A 247 ILE A 251 5 ? 5  
HELX_P HELX_P5 AA5 CYS A 86  ? CYS A 103 ? CYS A 266 CYS A 283 1 ? 18 
HELX_P HELX_P6 AA6 ASP A 155 ? GLY A 160 ? ASP A 335 GLY A 340 1 ? 6  
HELX_P HELX_P7 AA7 ALA A 213 ? THR A 225 ? ALA A 393 THR A 405 1 ? 13 
HELX_P HELX_P8 AA8 ASP B 2   ? LEU B 6   ? ASP B 525 LEU B 529 5 ? 5  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 6 ? 
AA3 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA2 5 6 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ILE A 27  ? VAL A 30  ? ILE A 207 VAL A 210 
AA1 2 ARG A 182 ? TRP A 187 ? ARG A 362 TRP A 367 
AA1 3 ARG A 142 ? TYR A 149 ? ARG A 322 TYR A 329 
AA1 4 THR A 202 ? ASP A 212 ? THR A 382 ASP A 392 
AA1 5 ALA A 118 ? PRO A 124 ? ALA A 298 PRO A 304 
AA1 6 LYS A 75  ? ILE A 79  ? LYS A 255 ILE A 259 
AA1 7 THR A 56  ? ASP A 57  ? THR A 236 ASP A 237 
AA2 1 ILE A 27  ? VAL A 30  ? ILE A 207 VAL A 210 
AA2 2 ARG A 182 ? TRP A 187 ? ARG A 362 TRP A 367 
AA2 3 ARG A 142 ? TYR A 149 ? ARG A 322 TYR A 329 
AA2 4 THR A 202 ? ASP A 212 ? THR A 382 ASP A 392 
AA2 5 ILE A 112 ? ARG A 115 ? ILE A 292 ARG A 295 
AA2 6 PHE B 17  ? GLN B 18  ? PHE B 540 GLN B 541 
AA3 1 THR A 128 ? HIS A 133 ? THR A 308 HIS A 313 
AA3 2 HIS A 194 ? ALA A 199 ? HIS A 374 ALA A 379 
AA3 3 LEU A 163 ? ILE A 165 ? LEU A 343 ILE A 345 
AA3 4 ALA A 174 ? ILE A 176 ? ALA A 354 ILE A 356 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N VAL A 30  ? N VAL A 210 O LEU A 183 ? O LEU A 363 
AA1 2 3 O PHE A 186 ? O PHE A 366 N THR A 145 ? N THR A 325 
AA1 3 4 N CYS A 146 ? N CYS A 326 O VAL A 208 ? O VAL A 388 
AA1 4 5 O SER A 207 ? O SER A 387 N MET A 119 ? N MET A 299 
AA1 5 6 O CYS A 122 ? O CYS A 302 N LYS A 75  ? N LYS A 255 
AA1 6 7 O ILE A 76  ? O ILE A 256 N THR A 56  ? N THR A 236 
AA2 1 2 N VAL A 30  ? N VAL A 210 O LEU A 183 ? O LEU A 363 
AA2 2 3 O PHE A 186 ? O PHE A 366 N THR A 145 ? N THR A 325 
AA2 3 4 N CYS A 146 ? N CYS A 326 O VAL A 208 ? O VAL A 388 
AA2 4 5 O PHE A 211 ? O PHE A 391 N GLY A 114 ? N GLY A 294 
AA2 5 6 N ARG A 115 ? N ARG A 295 O PHE B 17  ? O PHE B 540 
AA3 1 2 N HIS A 133 ? N HIS A 313 O HIS A 194 ? O HIS A 374 
AA3 2 3 O GLU A 195 ? O GLU A 375 N ARG A 164 ? N ARG A 344 
AA3 3 4 N ILE A 165 ? N ILE A 345 O ALA A 174 ? O ALA A 354 
# 
_pdbx_entry_details.entry_id                   8RUZ 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   O 
_pdbx_validate_close_contact.auth_asym_id_1   A 
_pdbx_validate_close_contact.auth_comp_id_1   HOH 
_pdbx_validate_close_contact.auth_seq_id_1    633 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   O 
_pdbx_validate_close_contact.auth_asym_id_2   A 
_pdbx_validate_close_contact.auth_comp_id_2   HOH 
_pdbx_validate_close_contact.auth_seq_id_2    675 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             2.17 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    OD2 
_pdbx_validate_symm_contact.auth_asym_id_1    A 
_pdbx_validate_symm_contact.auth_comp_id_1    ASP 
_pdbx_validate_symm_contact.auth_seq_id_1     224 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    NH2 
_pdbx_validate_symm_contact.auth_asym_id_2    A 
_pdbx_validate_symm_contact.auth_comp_id_2    ARG 
_pdbx_validate_symm_contact.auth_seq_id_2     370 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   1_554 
_pdbx_validate_symm_contact.dist              2.14 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 PHE A 346 ? ? -110.27 72.77   
2 1 ASP A 369 ? ? -79.93  -168.04 
3 1 ASP B 536 ? ? -74.78  -72.07  
4 1 GLU B 538 ? ? -124.67 -56.46  
5 1 ASP B 539 ? ? 88.08   151.90  
6 1 ASP B 539 ? ? 88.08   151.85  
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x+1/2,y+1/2,-z 
4 -x,-y,z         
# 
loop_
_pdbx_refine_tls.id 
_pdbx_refine_tls.pdbx_refine_id 
_pdbx_refine_tls.details 
_pdbx_refine_tls.method 
_pdbx_refine_tls.origin_x 
_pdbx_refine_tls.origin_y 
_pdbx_refine_tls.origin_z 
_pdbx_refine_tls.T[1][1] 
_pdbx_refine_tls.T[1][1]_esd 
_pdbx_refine_tls.T[1][2] 
_pdbx_refine_tls.T[1][2]_esd 
_pdbx_refine_tls.T[1][3] 
_pdbx_refine_tls.T[1][3]_esd 
_pdbx_refine_tls.T[2][2] 
_pdbx_refine_tls.T[2][2]_esd 
_pdbx_refine_tls.T[2][3] 
_pdbx_refine_tls.T[2][3]_esd 
_pdbx_refine_tls.T[3][3] 
_pdbx_refine_tls.T[3][3]_esd 
_pdbx_refine_tls.L[1][1] 
_pdbx_refine_tls.L[1][1]_esd 
_pdbx_refine_tls.L[1][2] 
_pdbx_refine_tls.L[1][2]_esd 
_pdbx_refine_tls.L[1][3] 
_pdbx_refine_tls.L[1][3]_esd 
_pdbx_refine_tls.L[2][2] 
_pdbx_refine_tls.L[2][2]_esd 
_pdbx_refine_tls.L[2][3] 
_pdbx_refine_tls.L[2][3]_esd 
_pdbx_refine_tls.L[3][3] 
_pdbx_refine_tls.L[3][3]_esd 
_pdbx_refine_tls.S[1][1] 
_pdbx_refine_tls.S[1][1]_esd 
_pdbx_refine_tls.S[1][2] 
_pdbx_refine_tls.S[1][2]_esd 
_pdbx_refine_tls.S[1][3] 
_pdbx_refine_tls.S[1][3]_esd 
_pdbx_refine_tls.S[2][1] 
_pdbx_refine_tls.S[2][1]_esd 
_pdbx_refine_tls.S[2][2] 
_pdbx_refine_tls.S[2][2]_esd 
_pdbx_refine_tls.S[2][3] 
_pdbx_refine_tls.S[2][3]_esd 
_pdbx_refine_tls.S[3][1] 
_pdbx_refine_tls.S[3][1]_esd 
_pdbx_refine_tls.S[3][2] 
_pdbx_refine_tls.S[3][2]_esd 
_pdbx_refine_tls.S[3][3] 
_pdbx_refine_tls.S[3][3]_esd 
1 'X-RAY DIFFRACTION' ? refined -14.387252167  24.6250497529 -11.7833842851 0.212750183589 ? -0.00462981724026 ? -0.0955146884356 
? 0.129463037157 ? 0.0765025482842  ? 0.349010628121 ? 0.931110148219   ? 1.42367417513   ? 0.590309277277   ? 2.72010044264  ? 
0.760486651614   ? 2.14846511339 ? -0.101564419746  ? 0.0598515991469  ? 0.164142785724   ? -0.158871932908  ? -0.000743714050011 
? 0.933726870587  ? -0.104461362587  ? 0.0755354903711  ? 0.128074078671   ? 
2 'X-RAY DIFFRACTION' ? refined -18.4781246314 5.56325784375 -26.5976808165 0.600129476995 ? 0.005409748636    ? -0.416995918026  
? 0.261041530667 ? 0.0183998302633  ? 0.542692054625 ? 1.13119580488    ? -0.580288150352 ? 0.566434852808   ? 0.296434467844 ? 
-0.314121908048  ? 1.14282574274 ? 0.0147668628956  ? 0.260990552776   ? -0.108901083491  ? -0.305787646498  ? 0.0673933092351    
? 0.274176250148  ? 0.0703508241416  ? -0.0448940303639 ? -0.165430421098  ? 
3 'X-RAY DIFFRACTION' ? refined -15.2647689001 2.87478853081 -12.8774687131 0.18073887134  ? 0.00766061909102  ? -0.0839468563069 
? 0.1248726237   ? 0.0117649266534  ? 0.309370669194 ? 1.36466190726    ? 0.289351301984  ? 0.234404800359   ? 1.46545953238  ? 
0.385045084637   ? 1.51002121921 ? -0.0349583934244 ? 0.059919769684   ? -0.383447420352  ? -0.266880363187  ? -0.0320652186477   
? 0.594072309434  ? 0.189708177434   ? 0.1067540182     ? 0.00400219616923 ? 
4 'X-RAY DIFFRACTION' ? refined -19.7493905408 9.79996312562 -9.10026589898 0.197094013734 ? -0.0191913395608  ? -0.0431501463437 
? 0.152597995445 ? 0.00456489751229 ? 0.548119317997 ? 0.459691734745   ? -0.188849793552 ? 0.158575771613   ? 1.11914858683  ? 
0.230928461086   ? 0.92741473671 ? -0.108594377271  ? -0.0595006196417 ? -0.0436667197287 ? 0.0394353861695  ? -0.064077415725    
? 1.01943892348   ? 0.00460960944289 ? -0.147688950418  ? 0.0671513112533  ? 
5 'X-RAY DIFFRACTION' ? refined -28.6161205403 19.2248776148 -1.4304749522  0.280152557104 ? 0.0582066664576   ? 0.188476381764   
? 0.266371386986 ? 0.00838747707034 ? 1.07289030557  ? 1.36118966377    ? -1.29968473275  ? -0.0587633837925 ? 1.71700408614  ? 
0.917902697759   ? 1.56189906356 ? -0.100094481696  ? -0.160094061825  ? 0.314682517914   ? 0.0846577954006  ? -0.00706359893853  
? 0.0221675343918 ? -0.218723165477  ? -0.130519433197  ? -0.0466248158808 ? 
6 'X-RAY DIFFRACTION' ? refined -17.7850794939 9.96757804323 -6.04258521843 0.266498789494 ? -0.0186407574103  ? 0.0223911712445  
? 0.107108678682 ? 0.0602812056052  ? 0.425505688177 ? 1.93227610449    ? 0.226011945127  ? 0.564110348327   ? 1.48775658078  ? 
-0.0430298817668 ? 1.62058842392 ? 0.178202798212   ? -0.0349666779815 ? -0.393478950148  ? 0.166583596091   ? 0.0747218418451    
? 0.918687300782  ? 0.0981080892339  ? -0.0134798232278 ? -0.123944722056  ? 
7 'X-RAY DIFFRACTION' ? refined -22.0857639974 1.4524279674  6.12780129162  0.246887075148 ? 0.0252805604803   ? 0.118787871372   
? 0.138398669669 ? -0.130120908273  ? 0.668587951201 ? 0.00431821972103 ? 0.025805519782  ? -0.0845689831026 ? 5.74781426312  ? 
1.81010688002    ? 2.48579105885 ? -0.104862678635  ? -0.0542160631835 ? -0.108268820907  ? 0.510710203033   ? 0.112659955571     
? 0.231186149749  ? 0.0531336104999  ? -0.0553808933438 ? 0.109559277947   ? 
8 'X-RAY DIFFRACTION' ? refined -8.49298905257 2.88074549326 -5.56428386852 0.190040334233 ? 0.0258326747002   ? 0.015158251251   
? 0.131284951012 ? -0.0164470081107 ? 0.218918494321 ? 8.02799997715    ? 4.80367461486   ? -5.84708589123   ? 4.84596636999  ? 
-3.79314706434   ? 5.60580959122 ? -0.157680973845  ? -0.525283800822  ? -0.671865628626  ? -0.0169486833849 ? -0.274226933096    
? 0.183080539432  ? 0.322907627362   ? 0.320678777293   ? 0.423251488935   ? 
# 
loop_
_pdbx_refine_tls_group.id 
_pdbx_refine_tls_group.pdbx_refine_id 
_pdbx_refine_tls_group.refine_tls_id 
_pdbx_refine_tls_group.beg_label_asym_id 
_pdbx_refine_tls_group.beg_label_seq_id 
_pdbx_refine_tls_group.beg_auth_asym_id 
_pdbx_refine_tls_group.beg_auth_seq_id 
_pdbx_refine_tls_group.beg_PDB_ins_code 
_pdbx_refine_tls_group.end_label_asym_id 
_pdbx_refine_tls_group.end_label_seq_id 
_pdbx_refine_tls_group.end_auth_asym_id 
_pdbx_refine_tls_group.end_auth_seq_id 
_pdbx_refine_tls_group.end_PDB_ins_code 
_pdbx_refine_tls_group.selection 
_pdbx_refine_tls_group.selection_details 
1 'X-RAY DIFFRACTION' 1 A 1   A 188 ? A 28  A 215 ? ? 
;chain 'A' and (resid 188 through 215 )
;
2 'X-RAY DIFFRACTION' 2 A 29  A 216 ? A 44  A 231 ? ? 
;chain 'A' and (resid 216 through 231 )
;
3 'X-RAY DIFFRACTION' 3 A 45  A 232 ? A 96  A 283 ? ? 
;chain 'A' and (resid 232 through 283 )
;
4 'X-RAY DIFFRACTION' 4 A 97  A 284 ? A 155 A 342 ? ? 
;chain 'A' and (resid 284 through 342 )
;
5 'X-RAY DIFFRACTION' 5 A 156 A 343 ? A 166 A 353 ? ? 
;chain 'A' and (resid 343 through 353 )
;
6 'X-RAY DIFFRACTION' 6 A 167 A 354 ? A 219 A 406 ? ? 
;chain 'A' and (resid 354 through 406 )
;
7 'X-RAY DIFFRACTION' 7 C 1   B 524 ? C 5   B 528 ? ? 
;chain 'B' and (resid 524 through 528 )
;
8 'X-RAY DIFFRACTION' 8 C 6   B 529 ? C 19  B 542 ? ? 
;chain 'B' and (resid 529 through 542 )
;
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A PRO 181 ? A PRO 1   
2 1 Y 1 A ASN 182 ? A ASN 2   
3 1 Y 1 A GLY 183 ? A GLY 3   
4 1 Y 1 A GLN 184 ? A GLN 4   
5 1 Y 1 A THR 185 ? A THR 5   
6 1 Y 1 A LYS 186 ? A LYS 6   
7 1 Y 1 A PRO 187 ? A PRO 7   
8 1 Y 1 A GLU 407 ? A GLU 227 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ACT C    C N N 1   
ACT O    O N N 2   
ACT OXT  O N N 3   
ACT CH3  C N N 4   
ACT H1   H N N 5   
ACT H2   H N N 6   
ACT H3   H N N 7   
ALA N    N N N 8   
ALA CA   C N S 9   
ALA C    C N N 10  
ALA O    O N N 11  
ALA CB   C N N 12  
ALA OXT  O N N 13  
ALA H    H N N 14  
ALA H2   H N N 15  
ALA HA   H N N 16  
ALA HB1  H N N 17  
ALA HB2  H N N 18  
ALA HB3  H N N 19  
ALA HXT  H N N 20  
ARG N    N N N 21  
ARG CA   C N S 22  
ARG C    C N N 23  
ARG O    O N N 24  
ARG CB   C N N 25  
ARG CG   C N N 26  
ARG CD   C N N 27  
ARG NE   N N N 28  
ARG CZ   C N N 29  
ARG NH1  N N N 30  
ARG NH2  N N N 31  
ARG OXT  O N N 32  
ARG H    H N N 33  
ARG H2   H N N 34  
ARG HA   H N N 35  
ARG HB2  H N N 36  
ARG HB3  H N N 37  
ARG HG2  H N N 38  
ARG HG3  H N N 39  
ARG HD2  H N N 40  
ARG HD3  H N N 41  
ARG HE   H N N 42  
ARG HH11 H N N 43  
ARG HH12 H N N 44  
ARG HH21 H N N 45  
ARG HH22 H N N 46  
ARG HXT  H N N 47  
ASN N    N N N 48  
ASN CA   C N S 49  
ASN C    C N N 50  
ASN O    O N N 51  
ASN CB   C N N 52  
ASN CG   C N N 53  
ASN OD1  O N N 54  
ASN ND2  N N N 55  
ASN OXT  O N N 56  
ASN H    H N N 57  
ASN H2   H N N 58  
ASN HA   H N N 59  
ASN HB2  H N N 60  
ASN HB3  H N N 61  
ASN HD21 H N N 62  
ASN HD22 H N N 63  
ASN HXT  H N N 64  
ASP N    N N N 65  
ASP CA   C N S 66  
ASP C    C N N 67  
ASP O    O N N 68  
ASP CB   C N N 69  
ASP CG   C N N 70  
ASP OD1  O N N 71  
ASP OD2  O N N 72  
ASP OXT  O N N 73  
ASP H    H N N 74  
ASP H2   H N N 75  
ASP HA   H N N 76  
ASP HB2  H N N 77  
ASP HB3  H N N 78  
ASP HD2  H N N 79  
ASP HXT  H N N 80  
CYS N    N N N 81  
CYS CA   C N R 82  
CYS C    C N N 83  
CYS O    O N N 84  
CYS CB   C N N 85  
CYS SG   S N N 86  
CYS OXT  O N N 87  
CYS H    H N N 88  
CYS H2   H N N 89  
CYS HA   H N N 90  
CYS HB2  H N N 91  
CYS HB3  H N N 92  
CYS HG   H N N 93  
CYS HXT  H N N 94  
GLN N    N N N 95  
GLN CA   C N S 96  
GLN C    C N N 97  
GLN O    O N N 98  
GLN CB   C N N 99  
GLN CG   C N N 100 
GLN CD   C N N 101 
GLN OE1  O N N 102 
GLN NE2  N N N 103 
GLN OXT  O N N 104 
GLN H    H N N 105 
GLN H2   H N N 106 
GLN HA   H N N 107 
GLN HB2  H N N 108 
GLN HB3  H N N 109 
GLN HG2  H N N 110 
GLN HG3  H N N 111 
GLN HE21 H N N 112 
GLN HE22 H N N 113 
GLN HXT  H N N 114 
GLU N    N N N 115 
GLU CA   C N S 116 
GLU C    C N N 117 
GLU O    O N N 118 
GLU CB   C N N 119 
GLU CG   C N N 120 
GLU CD   C N N 121 
GLU OE1  O N N 122 
GLU OE2  O N N 123 
GLU OXT  O N N 124 
GLU H    H N N 125 
GLU H2   H N N 126 
GLU HA   H N N 127 
GLU HB2  H N N 128 
GLU HB3  H N N 129 
GLU HG2  H N N 130 
GLU HG3  H N N 131 
GLU HE2  H N N 132 
GLU HXT  H N N 133 
GLY N    N N N 134 
GLY CA   C N N 135 
GLY C    C N N 136 
GLY O    O N N 137 
GLY OXT  O N N 138 
GLY H    H N N 139 
GLY H2   H N N 140 
GLY HA2  H N N 141 
GLY HA3  H N N 142 
GLY HXT  H N N 143 
HIS N    N N N 144 
HIS CA   C N S 145 
HIS C    C N N 146 
HIS O    O N N 147 
HIS CB   C N N 148 
HIS CG   C Y N 149 
HIS ND1  N Y N 150 
HIS CD2  C Y N 151 
HIS CE1  C Y N 152 
HIS NE2  N Y N 153 
HIS OXT  O N N 154 
HIS H    H N N 155 
HIS H2   H N N 156 
HIS HA   H N N 157 
HIS HB2  H N N 158 
HIS HB3  H N N 159 
HIS HD1  H N N 160 
HIS HD2  H N N 161 
HIS HE1  H N N 162 
HIS HE2  H N N 163 
HIS HXT  H N N 164 
HOH O    O N N 165 
HOH H1   H N N 166 
HOH H2   H N N 167 
ILE N    N N N 168 
ILE CA   C N S 169 
ILE C    C N N 170 
ILE O    O N N 171 
ILE CB   C N S 172 
ILE CG1  C N N 173 
ILE CG2  C N N 174 
ILE CD1  C N N 175 
ILE OXT  O N N 176 
ILE H    H N N 177 
ILE H2   H N N 178 
ILE HA   H N N 179 
ILE HB   H N N 180 
ILE HG12 H N N 181 
ILE HG13 H N N 182 
ILE HG21 H N N 183 
ILE HG22 H N N 184 
ILE HG23 H N N 185 
ILE HD11 H N N 186 
ILE HD12 H N N 187 
ILE HD13 H N N 188 
ILE HXT  H N N 189 
LEU N    N N N 190 
LEU CA   C N S 191 
LEU C    C N N 192 
LEU O    O N N 193 
LEU CB   C N N 194 
LEU CG   C N N 195 
LEU CD1  C N N 196 
LEU CD2  C N N 197 
LEU OXT  O N N 198 
LEU H    H N N 199 
LEU H2   H N N 200 
LEU HA   H N N 201 
LEU HB2  H N N 202 
LEU HB3  H N N 203 
LEU HG   H N N 204 
LEU HD11 H N N 205 
LEU HD12 H N N 206 
LEU HD13 H N N 207 
LEU HD21 H N N 208 
LEU HD22 H N N 209 
LEU HD23 H N N 210 
LEU HXT  H N N 211 
LYS N    N N N 212 
LYS CA   C N S 213 
LYS C    C N N 214 
LYS O    O N N 215 
LYS CB   C N N 216 
LYS CG   C N N 217 
LYS CD   C N N 218 
LYS CE   C N N 219 
LYS NZ   N N N 220 
LYS OXT  O N N 221 
LYS H    H N N 222 
LYS H2   H N N 223 
LYS HA   H N N 224 
LYS HB2  H N N 225 
LYS HB3  H N N 226 
LYS HG2  H N N 227 
LYS HG3  H N N 228 
LYS HD2  H N N 229 
LYS HD3  H N N 230 
LYS HE2  H N N 231 
LYS HE3  H N N 232 
LYS HZ1  H N N 233 
LYS HZ2  H N N 234 
LYS HZ3  H N N 235 
LYS HXT  H N N 236 
MET N    N N N 237 
MET CA   C N S 238 
MET C    C N N 239 
MET O    O N N 240 
MET CB   C N N 241 
MET CG   C N N 242 
MET SD   S N N 243 
MET CE   C N N 244 
MET OXT  O N N 245 
MET H    H N N 246 
MET H2   H N N 247 
MET HA   H N N 248 
MET HB2  H N N 249 
MET HB3  H N N 250 
MET HG2  H N N 251 
MET HG3  H N N 252 
MET HE1  H N N 253 
MET HE2  H N N 254 
MET HE3  H N N 255 
MET HXT  H N N 256 
PHE N    N N N 257 
PHE CA   C N S 258 
PHE C    C N N 259 
PHE O    O N N 260 
PHE CB   C N N 261 
PHE CG   C Y N 262 
PHE CD1  C Y N 263 
PHE CD2  C Y N 264 
PHE CE1  C Y N 265 
PHE CE2  C Y N 266 
PHE CZ   C Y N 267 
PHE OXT  O N N 268 
PHE H    H N N 269 
PHE H2   H N N 270 
PHE HA   H N N 271 
PHE HB2  H N N 272 
PHE HB3  H N N 273 
PHE HD1  H N N 274 
PHE HD2  H N N 275 
PHE HE1  H N N 276 
PHE HE2  H N N 277 
PHE HZ   H N N 278 
PHE HXT  H N N 279 
PRO N    N N N 280 
PRO CA   C N S 281 
PRO C    C N N 282 
PRO O    O N N 283 
PRO CB   C N N 284 
PRO CG   C N N 285 
PRO CD   C N N 286 
PRO OXT  O N N 287 
PRO H    H N N 288 
PRO HA   H N N 289 
PRO HB2  H N N 290 
PRO HB3  H N N 291 
PRO HG2  H N N 292 
PRO HG3  H N N 293 
PRO HD2  H N N 294 
PRO HD3  H N N 295 
PRO HXT  H N N 296 
SER N    N N N 297 
SER CA   C N S 298 
SER C    C N N 299 
SER O    O N N 300 
SER CB   C N N 301 
SER OG   O N N 302 
SER OXT  O N N 303 
SER H    H N N 304 
SER H2   H N N 305 
SER HA   H N N 306 
SER HB2  H N N 307 
SER HB3  H N N 308 
SER HG   H N N 309 
SER HXT  H N N 310 
THR N    N N N 311 
THR CA   C N S 312 
THR C    C N N 313 
THR O    O N N 314 
THR CB   C N R 315 
THR OG1  O N N 316 
THR CG2  C N N 317 
THR OXT  O N N 318 
THR H    H N N 319 
THR H2   H N N 320 
THR HA   H N N 321 
THR HB   H N N 322 
THR HG1  H N N 323 
THR HG21 H N N 324 
THR HG22 H N N 325 
THR HG23 H N N 326 
THR HXT  H N N 327 
TRP N    N N N 328 
TRP CA   C N S 329 
TRP C    C N N 330 
TRP O    O N N 331 
TRP CB   C N N 332 
TRP CG   C Y N 333 
TRP CD1  C Y N 334 
TRP CD2  C Y N 335 
TRP NE1  N Y N 336 
TRP CE2  C Y N 337 
TRP CE3  C Y N 338 
TRP CZ2  C Y N 339 
TRP CZ3  C Y N 340 
TRP CH2  C Y N 341 
TRP OXT  O N N 342 
TRP H    H N N 343 
TRP H2   H N N 344 
TRP HA   H N N 345 
TRP HB2  H N N 346 
TRP HB3  H N N 347 
TRP HD1  H N N 348 
TRP HE1  H N N 349 
TRP HE3  H N N 350 
TRP HZ2  H N N 351 
TRP HZ3  H N N 352 
TRP HH2  H N N 353 
TRP HXT  H N N 354 
TYR N    N N N 355 
TYR CA   C N S 356 
TYR C    C N N 357 
TYR O    O N N 358 
TYR CB   C N N 359 
TYR CG   C Y N 360 
TYR CD1  C Y N 361 
TYR CD2  C Y N 362 
TYR CE1  C Y N 363 
TYR CE2  C Y N 364 
TYR CZ   C Y N 365 
TYR OH   O N N 366 
TYR OXT  O N N 367 
TYR H    H N N 368 
TYR H2   H N N 369 
TYR HA   H N N 370 
TYR HB2  H N N 371 
TYR HB3  H N N 372 
TYR HD1  H N N 373 
TYR HD2  H N N 374 
TYR HE1  H N N 375 
TYR HE2  H N N 376 
TYR HH   H N N 377 
TYR HXT  H N N 378 
VAL N    N N N 379 
VAL CA   C N S 380 
VAL C    C N N 381 
VAL O    O N N 382 
VAL CB   C N N 383 
VAL CG1  C N N 384 
VAL CG2  C N N 385 
VAL OXT  O N N 386 
VAL H    H N N 387 
VAL H2   H N N 388 
VAL HA   H N N 389 
VAL HB   H N N 390 
VAL HG11 H N N 391 
VAL HG12 H N N 392 
VAL HG13 H N N 393 
VAL HG21 H N N 394 
VAL HG22 H N N 395 
VAL HG23 H N N 396 
VAL HXT  H N N 397 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ACT C   O    doub N N 1   
ACT C   OXT  sing N N 2   
ACT C   CH3  sing N N 3   
ACT CH3 H1   sing N N 4   
ACT CH3 H2   sing N N 5   
ACT CH3 H3   sing N N 6   
ALA N   CA   sing N N 7   
ALA N   H    sing N N 8   
ALA N   H2   sing N N 9   
ALA CA  C    sing N N 10  
ALA CA  CB   sing N N 11  
ALA CA  HA   sing N N 12  
ALA C   O    doub N N 13  
ALA C   OXT  sing N N 14  
ALA CB  HB1  sing N N 15  
ALA CB  HB2  sing N N 16  
ALA CB  HB3  sing N N 17  
ALA OXT HXT  sing N N 18  
ARG N   CA   sing N N 19  
ARG N   H    sing N N 20  
ARG N   H2   sing N N 21  
ARG CA  C    sing N N 22  
ARG CA  CB   sing N N 23  
ARG CA  HA   sing N N 24  
ARG C   O    doub N N 25  
ARG C   OXT  sing N N 26  
ARG CB  CG   sing N N 27  
ARG CB  HB2  sing N N 28  
ARG CB  HB3  sing N N 29  
ARG CG  CD   sing N N 30  
ARG CG  HG2  sing N N 31  
ARG CG  HG3  sing N N 32  
ARG CD  NE   sing N N 33  
ARG CD  HD2  sing N N 34  
ARG CD  HD3  sing N N 35  
ARG NE  CZ   sing N N 36  
ARG NE  HE   sing N N 37  
ARG CZ  NH1  sing N N 38  
ARG CZ  NH2  doub N N 39  
ARG NH1 HH11 sing N N 40  
ARG NH1 HH12 sing N N 41  
ARG NH2 HH21 sing N N 42  
ARG NH2 HH22 sing N N 43  
ARG OXT HXT  sing N N 44  
ASN N   CA   sing N N 45  
ASN N   H    sing N N 46  
ASN N   H2   sing N N 47  
ASN CA  C    sing N N 48  
ASN CA  CB   sing N N 49  
ASN CA  HA   sing N N 50  
ASN C   O    doub N N 51  
ASN C   OXT  sing N N 52  
ASN CB  CG   sing N N 53  
ASN CB  HB2  sing N N 54  
ASN CB  HB3  sing N N 55  
ASN CG  OD1  doub N N 56  
ASN CG  ND2  sing N N 57  
ASN ND2 HD21 sing N N 58  
ASN ND2 HD22 sing N N 59  
ASN OXT HXT  sing N N 60  
ASP N   CA   sing N N 61  
ASP N   H    sing N N 62  
ASP N   H2   sing N N 63  
ASP CA  C    sing N N 64  
ASP CA  CB   sing N N 65  
ASP CA  HA   sing N N 66  
ASP C   O    doub N N 67  
ASP C   OXT  sing N N 68  
ASP CB  CG   sing N N 69  
ASP CB  HB2  sing N N 70  
ASP CB  HB3  sing N N 71  
ASP CG  OD1  doub N N 72  
ASP CG  OD2  sing N N 73  
ASP OD2 HD2  sing N N 74  
ASP OXT HXT  sing N N 75  
CYS N   CA   sing N N 76  
CYS N   H    sing N N 77  
CYS N   H2   sing N N 78  
CYS CA  C    sing N N 79  
CYS CA  CB   sing N N 80  
CYS CA  HA   sing N N 81  
CYS C   O    doub N N 82  
CYS C   OXT  sing N N 83  
CYS CB  SG   sing N N 84  
CYS CB  HB2  sing N N 85  
CYS CB  HB3  sing N N 86  
CYS SG  HG   sing N N 87  
CYS OXT HXT  sing N N 88  
GLN N   CA   sing N N 89  
GLN N   H    sing N N 90  
GLN N   H2   sing N N 91  
GLN CA  C    sing N N 92  
GLN CA  CB   sing N N 93  
GLN CA  HA   sing N N 94  
GLN C   O    doub N N 95  
GLN C   OXT  sing N N 96  
GLN CB  CG   sing N N 97  
GLN CB  HB2  sing N N 98  
GLN CB  HB3  sing N N 99  
GLN CG  CD   sing N N 100 
GLN CG  HG2  sing N N 101 
GLN CG  HG3  sing N N 102 
GLN CD  OE1  doub N N 103 
GLN CD  NE2  sing N N 104 
GLN NE2 HE21 sing N N 105 
GLN NE2 HE22 sing N N 106 
GLN OXT HXT  sing N N 107 
GLU N   CA   sing N N 108 
GLU N   H    sing N N 109 
GLU N   H2   sing N N 110 
GLU CA  C    sing N N 111 
GLU CA  CB   sing N N 112 
GLU CA  HA   sing N N 113 
GLU C   O    doub N N 114 
GLU C   OXT  sing N N 115 
GLU CB  CG   sing N N 116 
GLU CB  HB2  sing N N 117 
GLU CB  HB3  sing N N 118 
GLU CG  CD   sing N N 119 
GLU CG  HG2  sing N N 120 
GLU CG  HG3  sing N N 121 
GLU CD  OE1  doub N N 122 
GLU CD  OE2  sing N N 123 
GLU OE2 HE2  sing N N 124 
GLU OXT HXT  sing N N 125 
GLY N   CA   sing N N 126 
GLY N   H    sing N N 127 
GLY N   H2   sing N N 128 
GLY CA  C    sing N N 129 
GLY CA  HA2  sing N N 130 
GLY CA  HA3  sing N N 131 
GLY C   O    doub N N 132 
GLY C   OXT  sing N N 133 
GLY OXT HXT  sing N N 134 
HIS N   CA   sing N N 135 
HIS N   H    sing N N 136 
HIS N   H2   sing N N 137 
HIS CA  C    sing N N 138 
HIS CA  CB   sing N N 139 
HIS CA  HA   sing N N 140 
HIS C   O    doub N N 141 
HIS C   OXT  sing N N 142 
HIS CB  CG   sing N N 143 
HIS CB  HB2  sing N N 144 
HIS CB  HB3  sing N N 145 
HIS CG  ND1  sing Y N 146 
HIS CG  CD2  doub Y N 147 
HIS ND1 CE1  doub Y N 148 
HIS ND1 HD1  sing N N 149 
HIS CD2 NE2  sing Y N 150 
HIS CD2 HD2  sing N N 151 
HIS CE1 NE2  sing Y N 152 
HIS CE1 HE1  sing N N 153 
HIS NE2 HE2  sing N N 154 
HIS OXT HXT  sing N N 155 
HOH O   H1   sing N N 156 
HOH O   H2   sing N N 157 
ILE N   CA   sing N N 158 
ILE N   H    sing N N 159 
ILE N   H2   sing N N 160 
ILE CA  C    sing N N 161 
ILE CA  CB   sing N N 162 
ILE CA  HA   sing N N 163 
ILE C   O    doub N N 164 
ILE C   OXT  sing N N 165 
ILE CB  CG1  sing N N 166 
ILE CB  CG2  sing N N 167 
ILE CB  HB   sing N N 168 
ILE CG1 CD1  sing N N 169 
ILE CG1 HG12 sing N N 170 
ILE CG1 HG13 sing N N 171 
ILE CG2 HG21 sing N N 172 
ILE CG2 HG22 sing N N 173 
ILE CG2 HG23 sing N N 174 
ILE CD1 HD11 sing N N 175 
ILE CD1 HD12 sing N N 176 
ILE CD1 HD13 sing N N 177 
ILE OXT HXT  sing N N 178 
LEU N   CA   sing N N 179 
LEU N   H    sing N N 180 
LEU N   H2   sing N N 181 
LEU CA  C    sing N N 182 
LEU CA  CB   sing N N 183 
LEU CA  HA   sing N N 184 
LEU C   O    doub N N 185 
LEU C   OXT  sing N N 186 
LEU CB  CG   sing N N 187 
LEU CB  HB2  sing N N 188 
LEU CB  HB3  sing N N 189 
LEU CG  CD1  sing N N 190 
LEU CG  CD2  sing N N 191 
LEU CG  HG   sing N N 192 
LEU CD1 HD11 sing N N 193 
LEU CD1 HD12 sing N N 194 
LEU CD1 HD13 sing N N 195 
LEU CD2 HD21 sing N N 196 
LEU CD2 HD22 sing N N 197 
LEU CD2 HD23 sing N N 198 
LEU OXT HXT  sing N N 199 
LYS N   CA   sing N N 200 
LYS N   H    sing N N 201 
LYS N   H2   sing N N 202 
LYS CA  C    sing N N 203 
LYS CA  CB   sing N N 204 
LYS CA  HA   sing N N 205 
LYS C   O    doub N N 206 
LYS C   OXT  sing N N 207 
LYS CB  CG   sing N N 208 
LYS CB  HB2  sing N N 209 
LYS CB  HB3  sing N N 210 
LYS CG  CD   sing N N 211 
LYS CG  HG2  sing N N 212 
LYS CG  HG3  sing N N 213 
LYS CD  CE   sing N N 214 
LYS CD  HD2  sing N N 215 
LYS CD  HD3  sing N N 216 
LYS CE  NZ   sing N N 217 
LYS CE  HE2  sing N N 218 
LYS CE  HE3  sing N N 219 
LYS NZ  HZ1  sing N N 220 
LYS NZ  HZ2  sing N N 221 
LYS NZ  HZ3  sing N N 222 
LYS OXT HXT  sing N N 223 
MET N   CA   sing N N 224 
MET N   H    sing N N 225 
MET N   H2   sing N N 226 
MET CA  C    sing N N 227 
MET CA  CB   sing N N 228 
MET CA  HA   sing N N 229 
MET C   O    doub N N 230 
MET C   OXT  sing N N 231 
MET CB  CG   sing N N 232 
MET CB  HB2  sing N N 233 
MET CB  HB3  sing N N 234 
MET CG  SD   sing N N 235 
MET CG  HG2  sing N N 236 
MET CG  HG3  sing N N 237 
MET SD  CE   sing N N 238 
MET CE  HE1  sing N N 239 
MET CE  HE2  sing N N 240 
MET CE  HE3  sing N N 241 
MET OXT HXT  sing N N 242 
PHE N   CA   sing N N 243 
PHE N   H    sing N N 244 
PHE N   H2   sing N N 245 
PHE CA  C    sing N N 246 
PHE CA  CB   sing N N 247 
PHE CA  HA   sing N N 248 
PHE C   O    doub N N 249 
PHE C   OXT  sing N N 250 
PHE CB  CG   sing N N 251 
PHE CB  HB2  sing N N 252 
PHE CB  HB3  sing N N 253 
PHE CG  CD1  doub Y N 254 
PHE CG  CD2  sing Y N 255 
PHE CD1 CE1  sing Y N 256 
PHE CD1 HD1  sing N N 257 
PHE CD2 CE2  doub Y N 258 
PHE CD2 HD2  sing N N 259 
PHE CE1 CZ   doub Y N 260 
PHE CE1 HE1  sing N N 261 
PHE CE2 CZ   sing Y N 262 
PHE CE2 HE2  sing N N 263 
PHE CZ  HZ   sing N N 264 
PHE OXT HXT  sing N N 265 
PRO N   CA   sing N N 266 
PRO N   CD   sing N N 267 
PRO N   H    sing N N 268 
PRO CA  C    sing N N 269 
PRO CA  CB   sing N N 270 
PRO CA  HA   sing N N 271 
PRO C   O    doub N N 272 
PRO C   OXT  sing N N 273 
PRO CB  CG   sing N N 274 
PRO CB  HB2  sing N N 275 
PRO CB  HB3  sing N N 276 
PRO CG  CD   sing N N 277 
PRO CG  HG2  sing N N 278 
PRO CG  HG3  sing N N 279 
PRO CD  HD2  sing N N 280 
PRO CD  HD3  sing N N 281 
PRO OXT HXT  sing N N 282 
SER N   CA   sing N N 283 
SER N   H    sing N N 284 
SER N   H2   sing N N 285 
SER CA  C    sing N N 286 
SER CA  CB   sing N N 287 
SER CA  HA   sing N N 288 
SER C   O    doub N N 289 
SER C   OXT  sing N N 290 
SER CB  OG   sing N N 291 
SER CB  HB2  sing N N 292 
SER CB  HB3  sing N N 293 
SER OG  HG   sing N N 294 
SER OXT HXT  sing N N 295 
THR N   CA   sing N N 296 
THR N   H    sing N N 297 
THR N   H2   sing N N 298 
THR CA  C    sing N N 299 
THR CA  CB   sing N N 300 
THR CA  HA   sing N N 301 
THR C   O    doub N N 302 
THR C   OXT  sing N N 303 
THR CB  OG1  sing N N 304 
THR CB  CG2  sing N N 305 
THR CB  HB   sing N N 306 
THR OG1 HG1  sing N N 307 
THR CG2 HG21 sing N N 308 
THR CG2 HG22 sing N N 309 
THR CG2 HG23 sing N N 310 
THR OXT HXT  sing N N 311 
TRP N   CA   sing N N 312 
TRP N   H    sing N N 313 
TRP N   H2   sing N N 314 
TRP CA  C    sing N N 315 
TRP CA  CB   sing N N 316 
TRP CA  HA   sing N N 317 
TRP C   O    doub N N 318 
TRP C   OXT  sing N N 319 
TRP CB  CG   sing N N 320 
TRP CB  HB2  sing N N 321 
TRP CB  HB3  sing N N 322 
TRP CG  CD1  doub Y N 323 
TRP CG  CD2  sing Y N 324 
TRP CD1 NE1  sing Y N 325 
TRP CD1 HD1  sing N N 326 
TRP CD2 CE2  doub Y N 327 
TRP CD2 CE3  sing Y N 328 
TRP NE1 CE2  sing Y N 329 
TRP NE1 HE1  sing N N 330 
TRP CE2 CZ2  sing Y N 331 
TRP CE3 CZ3  doub Y N 332 
TRP CE3 HE3  sing N N 333 
TRP CZ2 CH2  doub Y N 334 
TRP CZ2 HZ2  sing N N 335 
TRP CZ3 CH2  sing Y N 336 
TRP CZ3 HZ3  sing N N 337 
TRP CH2 HH2  sing N N 338 
TRP OXT HXT  sing N N 339 
TYR N   CA   sing N N 340 
TYR N   H    sing N N 341 
TYR N   H2   sing N N 342 
TYR CA  C    sing N N 343 
TYR CA  CB   sing N N 344 
TYR CA  HA   sing N N 345 
TYR C   O    doub N N 346 
TYR C   OXT  sing N N 347 
TYR CB  CG   sing N N 348 
TYR CB  HB2  sing N N 349 
TYR CB  HB3  sing N N 350 
TYR CG  CD1  doub Y N 351 
TYR CG  CD2  sing Y N 352 
TYR CD1 CE1  sing Y N 353 
TYR CD1 HD1  sing N N 354 
TYR CD2 CE2  doub Y N 355 
TYR CD2 HD2  sing N N 356 
TYR CE1 CZ   doub Y N 357 
TYR CE1 HE1  sing N N 358 
TYR CE2 CZ   sing Y N 359 
TYR CE2 HE2  sing N N 360 
TYR CZ  OH   sing N N 361 
TYR OH  HH   sing N N 362 
TYR OXT HXT  sing N N 363 
VAL N   CA   sing N N 364 
VAL N   H    sing N N 365 
VAL N   H2   sing N N 366 
VAL CA  C    sing N N 367 
VAL CA  CB   sing N N 368 
VAL CA  HA   sing N N 369 
VAL C   O    doub N N 370 
VAL C   OXT  sing N N 371 
VAL CB  CG1  sing N N 372 
VAL CB  CG2  sing N N 373 
VAL CB  HB   sing N N 374 
VAL CG1 HG11 sing N N 375 
VAL CG1 HG12 sing N N 376 
VAL CG1 HG13 sing N N 377 
VAL CG2 HG21 sing N N 378 
VAL CG2 HG22 sing N N 379 
VAL CG2 HG23 sing N N 380 
VAL OXT HXT  sing N N 381 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Biotechnology and Biological Sciences Research Council (BBSRC)' 'United Kingdom' 'BB/R013829/1, BB/J001694/2, BB/L000121/1' 1 
'Cancer Research UK'                                             'United Kingdom' C8717/A18245                               2 
'Wellcome Trust'                                                 'United Kingdom' 091857/7/10/7                              3 
'Other government'                                               ?                'Newton Abraham Scholarship'               4 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      Other 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          'PHD2 bound to HIF' 
# 
_space_group.name_H-M_alt     'P 21 21 2' 
_space_group.name_Hall        'P 2 2ab' 
_space_group.IT_number        18 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8RUZ 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.007675 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.026350 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.023767 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N    . LEU A 1 8   ? -10.35112 23.05445  -22.55705 1.000 67.34551 ? 188 LEU A N    1 
ATOM   2    C CA   . LEU A 1 8   ? -10.06399 24.41296  -22.11073 1.000 73.09515 ? 188 LEU A CA   1 
ATOM   3    C C    . LEU A 1 8   ? -8.77508  24.45577  -21.29475 1.000 55.76747 ? 188 LEU A C    1 
ATOM   4    O O    . LEU A 1 8   ? -8.33554  23.43048  -20.78138 1.000 45.81339 ? 188 LEU A O    1 
ATOM   5    C CB   . LEU A 1 8   ? -11.22470 24.95906  -21.28012 1.000 72.53817 ? 188 LEU A CB   1 
ATOM   6    H H    . LEU A 1 8   ? -11.04093 22.70084  -22.17888 1.000 81.26666 ? 188 LEU A H    1 
ATOM   7    H HA   . LEU A 1 8   ? -9.95208  24.98448  -22.88645 1.000 88.16623 ? 188 LEU A HA   1 
ATOM   8    N N    . PRO A 1 9   ? -8.17179  25.63689  -21.16900 1.000 44.81326 ? 189 PRO A N    1 
ATOM   9    C CA   . PRO A 1 9   ? -6.95946  25.75218  -20.34599 1.000 36.65916 ? 189 PRO A CA   1 
ATOM   10   C C    . PRO A 1 9   ? -7.21338  25.27136  -18.92426 1.000 25.80279 ? 189 PRO A C    1 
ATOM   11   O O    . PRO A 1 9   ? -8.17550  25.68348  -18.27277 1.000 34.56297 ? 189 PRO A O    1 
ATOM   12   C CB   . PRO A 1 9   ? -6.62258  27.24848  -20.38637 1.000 44.20293 ? 189 PRO A CB   1 
ATOM   13   C CG   . PRO A 1 9   ? -7.69963  27.92381  -21.15036 1.000 49.05497 ? 189 PRO A CG   1 
ATOM   14   C CD   . PRO A 1 9   ? -8.59793  26.91326  -21.76315 1.000 46.85275 ? 189 PRO A CD   1 
ATOM   15   H HA   . PRO A 1 9   ? -6.23242  25.24755  -20.74306 1.000 44.44304 ? 189 PRO A HA   1 
ATOM   16   H HB2  . PRO A 1 9   ? -6.58324  27.59272  -19.48036 1.000 53.49556 ? 189 PRO A HB2  1 
ATOM   17   H HB3  . PRO A 1 9   ? -5.76683  27.37260  -20.82589 1.000 53.49556 ? 189 PRO A HB3  1 
ATOM   18   H HG2  . PRO A 1 9   ? -8.20479  28.48635  -20.54269 1.000 59.31801 ? 189 PRO A HG2  1 
ATOM   19   H HG3  . PRO A 1 9   ? -7.29388  28.46616  -21.84471 1.000 59.31801 ? 189 PRO A HG3  1 
ATOM   20   H HD2  . PRO A 1 9   ? -9.52347  27.10052  -21.54130 1.000 56.67535 ? 189 PRO A HD2  1 
ATOM   21   H HD3  . PRO A 1 9   ? -8.48466  26.89571  -22.72635 1.000 56.67535 ? 189 PRO A HD3  1 
ATOM   22   N N    . ALA A 1 10  ? -6.31748  24.40769  -18.43707 1.000 35.95759 ? 190 ALA A N    1 
ATOM   23   C CA   . ALA A 1 10  ? -6.50752  23.79599  -17.12531 1.000 23.36952 ? 190 ALA A CA   1 
ATOM   24   C C    . ALA A 1 10  ? -6.29479  24.80023  -15.99953 1.000 25.52025 ? 190 ALA A C    1 
ATOM   25   O O    . ALA A 1 10  ? -7.02945  24.78943  -15.00639 1.000 23.30642 ? 190 ALA A O    1 
ATOM   26   C CB   . ALA A 1 10  ? -5.55988  22.60733  -16.96208 1.000 19.45604 ? 190 ALA A CB   1 
ATOM   27   H H    . ALA A 1 10  ? -5.59985  24.16312  -18.84302 1.000 43.60116 ? 190 ALA A H    1 
ATOM   28   H HA   . ALA A 1 10  ? -7.41988  23.47186  -17.06671 1.000 28.49548 ? 190 ALA A HA   1 
ATOM   29   H HB1  . ALA A 1 10  ? -5.69815  22.21097  -16.08762 1.000 23.79930 ? 190 ALA A HB1  1 
ATOM   30   H HB2  . ALA A 1 10  ? -5.74925  21.95506  -17.65459 1.000 23.79930 ? 190 ALA A HB2  1 
ATOM   31   H HB3  . ALA A 1 10  ? -4.64501  22.91940  -17.04288 1.000 23.79930 ? 190 ALA A HB3  1 
ATOM   32   N N    . LEU A 1 11  ? -5.29250  25.67056  -16.13115 1.000 18.84276 ? 191 LEU A N    1 
ATOM   33   C CA   . LEU A 1 11  ? -4.91231  26.53833  -15.02021 1.000 19.47291 ? 191 LEU A CA   1 
ATOM   34   C C    . LEU A 1 11  ? -6.05550  27.46519  -14.61997 1.000 15.82024 ? 191 LEU A C    1 
ATOM   35   O O    . LEU A 1 11  ? -6.43333  27.53297  -13.44271 1.000 19.12121 ? 191 LEU A O    1 
ATOM   36   C CB   . LEU A 1 11  ? -3.67016  27.34316  -15.40465 1.000 26.30953 ? 191 LEU A CB   1 
ATOM   37   C CG   . LEU A 1 11  ? -3.13346  28.33859  -14.37666 1.000 21.35668 ? 191 LEU A CG   1 
ATOM   38   C CD1  . LEU A 1 11  ? -2.84506  27.64962  -13.05673 1.000 16.94694 ? 191 LEU A CD1  1 
ATOM   39   C CD2  . LEU A 1 11  ? -1.88253  29.01552  -14.91173 1.000 19.29117 ? 191 LEU A CD2  1 
ATOM   40   H H    . LEU A 1 11  ? -4.82333  25.77630  -16.84411 1.000 23.06337 ? 191 LEU A H    1 
ATOM   41   H HA   . LEU A 1 11  ? -4.69770  25.98905  -14.25006 1.000 23.81954 ? 191 LEU A HA   1 
ATOM   42   H HB2  . LEU A 1 11  ? -2.95426  26.71504  -15.58867 1.000 32.02349 ? 191 LEU A HB2  1 
ATOM   43   H HB3  . LEU A 1 11  ? -3.88035  27.85023  -16.20440 1.000 32.02349 ? 191 LEU A HB3  1 
ATOM   44   H HG   . LEU A 1 11  ? -3.80522  29.01873  -14.21217 1.000 26.08006 ? 191 LEU A HG   1 
ATOM   45   H HD11 . LEU A 1 11  ? -2.38685  28.27109  -12.46960 1.000 20.78838 ? 191 LEU A HD11 1 
ATOM   46   H HD12 . LEU A 1 11  ? -3.68349  27.37237  -12.65540 1.000 20.78838 ? 191 LEU A HD12 1 
ATOM   47   H HD13 . LEU A 1 11  ? -2.28469  26.87502  -13.22064 1.000 20.78838 ? 191 LEU A HD13 1 
ATOM   48   H HD21 . LEU A 1 11  ? -1.53132  29.61234  -14.23249 1.000 23.60145 ? 191 LEU A HD21 1 
ATOM   49   H HD22 . LEU A 1 11  ? -1.22419  28.33682  -15.12816 1.000 23.60145 ? 191 LEU A HD22 1 
ATOM   50   H HD23 . LEU A 1 11  ? -2.11222  29.51943  -15.70811 1.000 23.60145 ? 191 LEU A HD23 1 
ATOM   51   N N    . LYS A 1 12  ? -6.61531  28.19437  -15.58835 1.000 29.93877 ? 192 LYS A N    1 
ATOM   52   C CA   . LYS A 1 12  ? -7.67281  29.15156  -15.27771 1.000 27.17633 ? 192 LYS A CA   1 
ATOM   53   C C    . LYS A 1 12  ? -8.91137  28.44339  -14.74555 1.000 21.36948 ? 192 LYS A C    1 
ATOM   54   O O    . LYS A 1 12  ? -9.49316  28.85611  -13.73541 1.000 32.49791 ? 192 LYS A O    1 
ATOM   55   C CB   . LYS A 1 12  ? -8.01637  29.97186  -16.52200 1.000 26.82106 ? 192 LYS A CB   1 
ATOM   56   C CG   . LYS A 1 12  ? -9.18740  30.92555  -16.33592 1.000 27.65242 ? 192 LYS A CG   1 
ATOM   57   C CD   . LYS A 1 12  ? -9.35458  31.84176  -17.53900 1.000 29.42467 ? 192 LYS A CD   1 
ATOM   58   H H    . LYS A 1 12  ? -6.40286  28.15328  -16.42069 1.000 36.37857 ? 192 LYS A H    1 
ATOM   59   H HA   . LYS A 1 12  ? -7.35373  29.75956  -14.59257 1.000 33.06365 ? 192 LYS A HA   1 
ATOM   60   H HB2  . LYS A 1 12  ? -7.24176  30.50134  -16.76806 1.000 32.63732 ? 192 LYS A HB2  1 
ATOM   61   H HB3  . LYS A 1 12  ? -8.24420  29.36289  -17.24182 1.000 32.63732 ? 192 LYS A HB3  1 
ATOM   62   H HG2  . LYS A 1 12  ? -10.00427 30.41416  -16.22593 1.000 33.63495 ? 192 LYS A HG2  1 
ATOM   63   H HG3  . LYS A 1 12  ? -9.03252  31.47595  -15.55236 1.000 33.63495 ? 192 LYS A HG3  1 
ATOM   64   N N    . LEU A 1 13  ? -9.32050  27.35956  -15.40733 1.000 17.78061 ? 193 LEU A N    1 
ATOM   65   C CA   . LEU A 1 13  ? -10.50327 26.63040  -14.96509 1.000 28.37682 ? 193 LEU A CA   1 
ATOM   66   C C    . LEU A 1 13  ? -10.32910 26.11958  -13.54124 1.000 16.46436 ? 193 LEU A C    1 
ATOM   67   O O    . LEU A 1 13  ? -11.24826 26.21727  -12.71958 1.000 32.59391 ? 193 LEU A O    1 
ATOM   68   C CB   . LEU A 1 13  ? -10.78411 25.47165  -15.92218 1.000 24.70767 ? 193 LEU A CB   1 
ATOM   69   C CG   . LEU A 1 13  ? -12.02499 24.62534  -15.63355 1.000 23.12066 ? 193 LEU A CG   1 
ATOM   70   C CD1  . LEU A 1 13  ? -13.28864 25.46306  -15.72050 1.000 22.03579 ? 193 LEU A CD1  1 
ATOM   71   C CD2  . LEU A 1 13  ? -12.09124 23.44614  -16.59301 1.000 24.72868 ? 193 LEU A CD2  1 
ATOM   72   H H    . LEU A 1 13  ? -8.93618  27.03242  -16.10366 1.000 21.78878 ? 193 LEU A H    1 
ATOM   73   H HA   . LEU A 1 13  ? -11.26853 27.22627  -14.97920 1.000 34.50424 ? 193 LEU A HA   1 
ATOM   74   H HB2  . LEU A 1 13  ? -10.89196 25.83892  -16.81346 1.000 30.10125 ? 193 LEU A HB2  1 
ATOM   75   H HB3  . LEU A 1 13  ? -10.02095 24.87333  -15.90001 1.000 30.10125 ? 193 LEU A HB3  1 
ATOM   76   H HG   . LEU A 1 13  ? -11.96725 24.27971  -14.72906 1.000 28.19684 ? 193 LEU A HG   1 
ATOM   77   H HD11 . LEU A 1 13  ? -14.05959 24.88307  -15.61975 1.000 26.89499 ? 193 LEU A HD11 1 
ATOM   78   H HD12 . LEU A 1 13  ? -13.27797 26.12520  -15.01172 1.000 26.89499 ? 193 LEU A HD12 1 
ATOM   79   H HD13 . LEU A 1 13  ? -13.31671 25.90355  -16.58426 1.000 26.89499 ? 193 LEU A HD13 1 
ATOM   80   H HD21 . LEU A 1 13  ? -12.87813 22.91689  -16.38907 1.000 30.12647 ? 193 LEU A HD21 1 
ATOM   81   H HD22 . LEU A 1 13  ? -12.14428 23.78105  -17.50182 1.000 30.12647 ? 193 LEU A HD22 1 
ATOM   82   H HD23 . LEU A 1 13  ? -11.29255 22.90629  -16.48552 1.000 30.12647 ? 193 LEU A HD23 1 
ATOM   83   N N    . ALA A 1 14  ? -9.15264  25.57577  -13.22991 1.000 22.29611 ? 194 ALA A N    1 
ATOM   84   C CA   . ALA A 1 14  ? -8.91236  25.02660  -11.90136 1.000 24.36628 ? 194 ALA A CA   1 
ATOM   85   C C    . ALA A 1 14  ? -8.89531  26.11825  -10.83888 1.000 23.48175 ? 194 ALA A C    1 
ATOM   86   O O    . ALA A 1 14  ? -9.58729  26.01468  -9.81909  1.000 18.00859 ? 194 ALA A O    1 
ATOM   87   C CB   . ALA A 1 14  ? -7.59356  24.25262  -11.89286 1.000 34.89445 ? 194 ALA A CB   1 
ATOM   88   H H    . ALA A 1 14  ? -8.48347  25.51362  -13.76652 1.000 27.20738 ? 194 ALA A H    1 
ATOM   89   H HA   . ALA A 1 14  ? -9.63228  24.41347  -11.68529 1.000 29.69158 ? 194 ALA A HA   1 
ATOM   90   H HB1  . ALA A 1 14  ? -7.35464  24.04586  -10.97576 1.000 42.32539 ? 194 ALA A HB1  1 
ATOM   91   H HB2  . ALA A 1 14  ? -7.70549  23.43241  -12.39847 1.000 42.32539 ? 194 ALA A HB2  1 
ATOM   92   H HB3  . ALA A 1 14  ? -6.90349  24.80005  -12.29908 1.000 42.32539 ? 194 ALA A HB3  1 
ATOM   93   N N    . LEU A 1 15  ? -8.11372  27.17817  -11.05686 1.000 17.65121 ? 195 LEU A N    1 
ATOM   94   C CA   . LEU A 1 15  ? -7.88233  28.13285  -9.97705  1.000 16.76530 ? 195 LEU A CA   1 
ATOM   95   C C    . LEU A 1 15  ? -9.03404  29.11930  -9.81898  1.000 15.65986 ? 195 LEU A C    1 
ATOM   96   O O    . LEU A 1 15  ? -9.39865  29.46752  -8.69039  1.000 23.97619 ? 195 LEU A O    1 
ATOM   97   C CB   . LEU A 1 15  ? -6.57291  28.88785  -10.20864 1.000 24.78626 ? 195 LEU A CB   1 
ATOM   98   C CG   . LEU A 1 15  ? -5.28271  28.09331  -9.99189  1.000 14.18543 ? 195 LEU A CG   1 
ATOM   99   C CD1  . LEU A 1 15  ? -4.07490  28.95175  -10.33274 1.000 14.54079 ? 195 LEU A CD1  1 
ATOM   100  C CD2  . LEU A 1 15  ? -5.18352  27.56968  -8.56461  1.000 24.74976 ? 195 LEU A CD2  1 
ATOM   101  H H    . LEU A 1 15  ? -7.71853  27.36036  -11.79864 1.000 21.63351 ? 195 LEU A H    1 
ATOM   102  H HA   . LEU A 1 15  ? -7.80484  27.63381  -9.14889  1.000 20.57041 ? 195 LEU A HA   1 
ATOM   103  H HB2  . LEU A 1 15  ? -6.56452  29.20131  -11.12656 1.000 30.19555 ? 195 LEU A HB2  1 
ATOM   104  H HB3  . LEU A 1 15  ? -6.54909  29.64279  -9.60003  1.000 30.19555 ? 195 LEU A HB3  1 
ATOM   105  H HG   . LEU A 1 15  ? -5.29094  27.32266  -10.58090 1.000 14.76228 ? 195 LEU A HG   1 
ATOM   106  H HD11 . LEU A 1 15  ? -3.27274  28.41116  -10.26055 1.000 17.90099 ? 195 LEU A HD11 1 
ATOM   107  H HD12 . LEU A 1 15  ? -4.16934  29.28410  -11.23912 1.000 17.90099 ? 195 LEU A HD12 1 
ATOM   108  H HD13 . LEU A 1 15  ? -4.03004  29.69488  -9.71093  1.000 17.90099 ? 195 LEU A HD13 1 
ATOM   109  H HD21 . LEU A 1 15  ? -4.28424  27.24021  -8.41088  1.000 30.15176 ? 195 LEU A HD21 1 
ATOM   110  H HD22 . LEU A 1 15  ? -5.38078  28.29255  -7.94861  1.000 30.15176 ? 195 LEU A HD22 1 
ATOM   111  H HD23 . LEU A 1 15  ? -5.82388  26.85068  -8.44679  1.000 30.15176 ? 195 LEU A HD23 1 
ATOM   112  N N    . GLU A 1 16  ? -9.61999  29.58358  -10.92137 1.000 23.63673 ? 196 GLU A N    1 
ATOM   113  C CA   . GLU A 1 16  ? -10.61946 30.63870  -10.83787 1.000 22.04467 ? 196 GLU A CA   1 
ATOM   114  C C    . GLU A 1 16  ? -12.04841 30.11959  -10.75110 1.000 27.00332 ? 196 GLU A C    1 
ATOM   115  O O    . GLU A 1 16  ? -12.93413 30.87506  -10.33298 1.000 22.45355 ? 196 GLU A O    1 
ATOM   116  C CB   . GLU A 1 16  ? -10.48510 31.57833  -12.04109 1.000 20.12772 ? 196 GLU A CB   1 
ATOM   117  C CG   . GLU A 1 16  ? -9.05184  32.02861  -12.29308 1.000 20.53440 ? 196 GLU A CG   1 
ATOM   118  C CD   . GLU A 1 16  ? -8.95520  33.20301  -13.24653 1.000 36.86317 ? 196 GLU A CD   1 
ATOM   119  O OE1  . GLU A 1 16  ? -10.00982 33.70920  -13.68474 1.000 45.67527 ? 196 GLU A OE1  1 
ATOM   120  O OE2  . GLU A 1 16  ? -7.81918  33.62135  -13.55568 1.000 30.16127 ? 196 GLU A OE2  1 
ATOM   121  H H    . GLU A 1 16  ? -9.45605  29.30552  -11.71850 1.000 28.81613 ? 196 GLU A H    1 
ATOM   122  H HA   . GLU A 1 16  ? -10.45700 31.15585  -10.03346 1.000 26.90566 ? 196 GLU A HA   1 
ATOM   123  H HB2  . GLU A 1 16  ? -10.79747 31.11781  -12.83559 1.000 24.60531 ? 196 GLU A HB2  1 
ATOM   124  H HB3  . GLU A 1 16  ? -11.02332 32.36971  -11.88316 1.000 24.60531 ? 196 GLU A HB3  1 
ATOM   125  H HG2  . GLU A 1 16  ? -8.65301  32.29524  -11.45002 1.000 25.09333 ? 196 GLU A HG2  1 
ATOM   126  H HG3  . GLU A 1 16  ? -8.55318  31.29064  -12.67731 1.000 25.09333 ? 196 GLU A HG3  1 
ATOM   127  N N    . TYR A 1 17  ? -12.30520 28.86721  -11.13808 1.000 22.86398 ? 197 TYR A N    1 
ATOM   128  C CA   . TYR A 1 17  ? -13.64811 28.30378  -11.03376 1.000 30.20554 ? 197 TYR A CA   1 
ATOM   129  C C    . TYR A 1 17  ? -13.72088 27.11246  -10.08745 1.000 19.75043 ? 197 TYR A C    1 
ATOM   130  O O    . TYR A 1 17  ? -14.48187 27.15519  -9.11692  1.000 19.66706 ? 197 TYR A O    1 
ATOM   131  C CB   . TYR A 1 17  ? -14.16087 27.89588  -12.42110 1.000 19.23710 ? 197 TYR A CB   1 
ATOM   132  C CG   . TYR A 1 17  ? -15.57612 27.36273  -12.39592 1.000 20.49525 ? 197 TYR A CG   1 
ATOM   133  C CD1  . TYR A 1 17  ? -16.60067 28.09500  -11.81194 1.000 28.35194 ? 197 TYR A CD1  1 
ATOM   134  C CD2  . TYR A 1 17  ? -15.88617 26.12428  -12.94114 1.000 25.59176 ? 197 TYR A CD2  1 
ATOM   135  C CE1  . TYR A 1 17  ? -17.89506 27.61562  -11.78102 1.000 36.58226 ? 197 TYR A CE1  1 
ATOM   136  C CE2  . TYR A 1 17  ? -17.17992 25.63585  -12.91366 1.000 29.49115 ? 197 TYR A CE2  1 
ATOM   137  C CZ   . TYR A 1 17  ? -18.17942 26.38588  -12.33116 1.000 30.31509 ? 197 TYR A CZ   1 
ATOM   138  O OH   . TYR A 1 17  ? -19.46916 25.90588  -12.29953 1.000 33.75904 ? 197 TYR A OH   1 
ATOM   139  H H    . TYR A 1 17  ? -11.71876 28.32838  -11.46267 1.000 27.88883 ? 197 TYR A H    1 
ATOM   140  H HA   . TYR A 1 17  ? -14.22476 28.99703  -10.67630 1.000 36.69870 ? 197 TYR A HA   1 
ATOM   141  H HB2  . TYR A 1 17  ? -14.14370 28.67145  -13.00342 1.000 23.33534 ? 197 TYR A HB2  1 
ATOM   142  H HB3  . TYR A 1 17  ? -13.58565 27.20079  -12.77728 1.000 23.33534 ? 197 TYR A HB3  1 
ATOM   143  H HD1  . TYR A 1 17  ? -16.41171 28.92373  -11.43459 1.000 34.47438 ? 197 TYR A HD1  1 
ATOM   144  H HD2  . TYR A 1 17  ? -15.21304 25.61473  -13.33122 1.000 31.16216 ? 197 TYR A HD2  1 
ATOM   145  H HE1  . TYR A 1 17  ? -18.57136 28.12071  -11.39063 1.000 44.35076 ? 197 TYR A HE1  1 
ATOM   146  H HE2  . TYR A 1 17  ? -17.37451 24.80616  -13.28602 1.000 35.84143 ? 197 TYR A HE2  1 
ATOM   147  H HH   . TYR A 1 17  ? -19.50071 25.14360  -12.65101 1.000 40.96289 ? 197 TYR A HH   1 
ATOM   148  N N    . ILE A 1 18  ? -12.94889 26.05113  -10.32847 1.000 19.34125 ? 198 ILE A N    1 
ATOM   149  C CA   . ILE A 1 18  ? -13.16953 24.79955  -9.60676  1.000 25.72804 ? 198 ILE A CA   1 
ATOM   150  C C    . ILE A 1 18  ? -12.81104 24.95459  -8.13383  1.000 16.70618 ? 198 ILE A C    1 
ATOM   151  O O    . ILE A 1 18  ? -13.55853 24.52325  -7.24866  1.000 17.20364 ? 198 ILE A O    1 
ATOM   152  C CB   . ILE A 1 18  ? -12.37605 23.65389  -10.26093 1.000 28.20088 ? 198 ILE A CB   1 
ATOM   153  C CG1  . ILE A 1 18  ? -12.96534 23.32259  -11.63392 1.000 21.71072 ? 198 ILE A CG1  1 
ATOM   154  C CG2  . ILE A 1 18  ? -12.38357 22.42246  -9.35916  1.000 29.36964 ? 198 ILE A CG2  1 
ATOM   155  C CD1  . ILE A 1 18  ? -12.14535 22.33310  -12.43798 1.000 18.78226 ? 198 ILE A CD1  1 
ATOM   156  H H    . ILE A 1 18  ? -12.30218 26.03047  -10.89499 1.000 23.66155 ? 198 ILE A H    1 
ATOM   157  H HA   . ILE A 1 18  ? -14.11334 24.58216  -9.66038  1.000 31.32570 ? 198 ILE A HA   1 
ATOM   158  H HB   . ILE A 1 18  ? -11.45715 23.94038  -10.38113 1.000 34.29311 ? 198 ILE A HB   1 
ATOM   159  H HG12 . ILE A 1 18  ? -13.84810 22.94049  -11.50885 1.000 26.50491 ? 198 ILE A HG12 1 
ATOM   160  H HG13 . ILE A 1 18  ? -13.02831 24.14121  -12.15044 1.000 26.50491 ? 198 ILE A HG13 1 
ATOM   161  H HG21 . ILE A 1 18  ? -12.09442 21.65258  -9.87354  1.000 35.69562 ? 198 ILE A HG21 1 
ATOM   162  H HG22 . ILE A 1 18  ? -11.77717 22.57096  -8.61678  1.000 35.69562 ? 198 ILE A HG22 1 
ATOM   163  H HG23 . ILE A 1 18  ? -13.28380 22.27946  -9.02742  1.000 35.69562 ? 198 ILE A HG23 1 
ATOM   164  H HD11 . ILE A 1 18  ? -12.45038 22.34468  -13.35869 1.000 22.99077 ? 198 ILE A HD11 1 
ATOM   165  H HD12 . ILE A 1 18  ? -11.21081 22.58953  -12.39588 1.000 22.99077 ? 198 ILE A HD12 1 
ATOM   166  H HD13 . ILE A 1 18  ? -12.26239 21.44668  -12.06187 1.000 22.99077 ? 198 ILE A HD13 1 
ATOM   167  N N    . VAL A 1 19  ? -11.66552 25.56349  -7.84900  1.000 16.04680 ? 199 VAL A N    1 
ATOM   168  C CA   . VAL A 1 19  ? -11.16519 25.67444  -6.48086  1.000 19.89506 ? 199 VAL A CA   1 
ATOM   169  C C    . VAL A 1 19  ? -12.15701 26.45050  -5.61937  1.000 18.82271 ? 199 VAL A C    1 
ATOM   170  O O    . VAL A 1 19  ? -12.61060 25.92705  -4.58720  1.000 21.32946 ? 199 VAL A O    1 
ATOM   171  C CB   . VAL A 1 19  ? -9.77474  26.33150  -6.46025  1.000 23.14834 ? 199 VAL A CB   1 
ATOM   172  C CG1  . VAL A 1 19  ? -9.45241  26.87849  -5.07597  1.000 22.32418 ? 199 VAL A CG1  1 
ATOM   173  C CG2  . VAL A 1 19  ? -8.71559  25.33189  -6.89761  1.000 16.51622 ? 199 VAL A CG2  1 
ATOM   174  H H    . VAL A 1 19  ? -11.15254 25.92532  -8.43683  1.000 17.90206 ? 199 VAL A H    1 
ATOM   175  H HA   . VAL A 1 19  ? -11.09751 24.78269  -6.10523  1.000 24.32612 ? 199 VAL A HA   1 
ATOM   176  H HB   . VAL A 1 19  ? -9.77265  27.07621  -7.08178  1.000 28.23006 ? 199 VAL A HB   1 
ATOM   177  H HG11 . VAL A 1 19  ? -8.50374  27.07477  -5.02700  1.000 27.24106 ? 199 VAL A HG11 1 
ATOM   178  H HG12 . VAL A 1 19  ? -9.96576  27.68828  -4.92899  1.000 27.24106 ? 199 VAL A HG12 1 
ATOM   179  H HG13 . VAL A 1 19  ? -9.68721  26.21269  -4.41078  1.000 27.24106 ? 199 VAL A HG13 1 
ATOM   180  H HG21 . VAL A 1 19  ? -7.87415  25.79790  -7.02296  1.000 20.27151 ? 199 VAL A HG21 1 
ATOM   181  H HG22 . VAL A 1 19  ? -8.61893  24.65352  -6.21106  1.000 20.27151 ? 199 VAL A HG22 1 
ATOM   182  H HG23 . VAL A 1 19  ? -8.99380  24.92148  -7.73131  1.000 20.27151 ? 199 VAL A HG23 1 
ATOM   183  N N    . PRO A 1 20  ? -12.49365 27.69902  -5.96793  1.000 21.27023 ? 200 PRO A N    1 
ATOM   184  C CA   . PRO A 1 20  ? -13.47476 28.43056  -5.14764  1.000 18.31311 ? 200 PRO A CA   1 
ATOM   185  C C    . PRO A 1 20  ? -14.82394 27.74041  -5.06815  1.000 23.65754 ? 200 PRO A C    1 
ATOM   186  O O    . PRO A 1 20  ? -15.46296 27.75955  -4.00837  1.000 25.85209 ? 200 PRO A O    1 
ATOM   187  C CB   . PRO A 1 20  ? -13.56635 29.79929  -5.84179  1.000 23.70392 ? 200 PRO A CB   1 
ATOM   188  C CG   . PRO A 1 20  ? -13.05381 29.58133  -7.22000  1.000 18.24834 ? 200 PRO A CG   1 
ATOM   189  C CD   . PRO A 1 20  ? -12.02667 28.49855  -7.11509  1.000 21.69650 ? 200 PRO A CD   1 
ATOM   190  H HA   . PRO A 1 20  ? -13.12520 28.55263  -4.25108  1.000 21.96342 ? 200 PRO A HA   1 
ATOM   191  H HB2  . PRO A 1 20  ? -14.48940 30.09687  -5.85975  1.000 28.89676 ? 200 PRO A HB2  1 
ATOM   192  H HB3  . PRO A 1 20  ? -13.01886 30.44472  -5.36789  1.000 28.89676 ? 200 PRO A HB3  1 
ATOM   193  H HG2  . PRO A 1 20  ? -13.78215 29.30758  -7.79921  1.000 21.43456 ? 200 PRO A HG2  1 
ATOM   194  H HG3  . PRO A 1 20  ? -12.65512 30.40055  -7.55292  1.000 21.43456 ? 200 PRO A HG3  1 
ATOM   195  H HD2  . PRO A 1 20  ? -12.00569 27.96299  -7.92357  1.000 26.48785 ? 200 PRO A HD2  1 
ATOM   196  H HD3  . PRO A 1 20  ? -11.14827 28.87152  -6.94132  1.000 26.48785 ? 200 PRO A HD3  1 
ATOM   197  N N    A CYS A 1 21  ? -15.27590 27.12249  -6.16238  0.580 23.10731 ? 201 CYS A N    1 
ATOM   198  N N    B CYS A 1 21  ? -15.27583 27.12002  -6.15971  0.420 23.10774 ? 201 CYS A N    1 
ATOM   199  C CA   A CYS A 1 21  ? -16.56213 26.43398  -6.14172  0.580 21.74229 ? 201 CYS A CA   1 
ATOM   200  C CA   B CYS A 1 21  ? -16.56726 26.44199  -6.13659  0.420 21.76442 ? 201 CYS A CA   1 
ATOM   201  C C    A CYS A 1 21  ? -16.56044 25.31399  -5.11214  0.580 20.34944 ? 201 CYS A C    1 
ATOM   202  C C    B CYS A 1 21  ? -16.56753 25.30841  -5.11867  0.420 20.35408 ? 201 CYS A C    1 
ATOM   203  O O    A CYS A 1 21  ? -17.50012 25.17713  -4.32223  0.580 25.46477 ? 201 CYS A O    1 
ATOM   204  O O    B CYS A 1 21  ? -17.51257 25.16111  -4.33641  0.420 25.41247 ? 201 CYS A O    1 
ATOM   205  C CB   A CYS A 1 21  ? -16.88558 25.87420  -7.52696  0.580 24.57457 ? 201 CYS A CB   1 
ATOM   206  C CB   B CYS A 1 21  ? -16.90857 25.91589  -7.53126  0.420 24.51804 ? 201 CYS A CB   1 
ATOM   207  S SG   A CYS A 1 21  ? -18.03373 26.87276  -8.48774  0.580 25.11804 ? 201 CYS A SG   1 
ATOM   208  S SG   B CYS A 1 21  ? -18.67977 25.81505  -7.87629  0.420 22.50491 ? 201 CYS A SG   1 
ATOM   209  H H    A CYS A 1 21  ? -14.86249 27.08890  -6.91574  0.580 28.18082 ? 201 CYS A H    1 
ATOM   210  H H    B CYS A 1 21  ? -14.86045 27.07871  -6.91162  0.420 28.18133 ? 201 CYS A H    1 
ATOM   211  H HA   A CYS A 1 21  ? -17.25153 27.07378  -5.90448  0.580 26.54280 ? 201 CYS A HA   1 
ATOM   212  H HA   B CYS A 1 21  ? -17.25237 27.07932  -5.88101  0.420 26.56935 ? 201 CYS A HA   1 
ATOM   213  H HB2  A CYS A 1 21  ? -16.06085 25.80769  -8.03321  0.580 29.94154 ? 201 CYS A HB2  1 
ATOM   214  H HB2  B CYS A 1 21  ? -16.51411 26.50809  -8.19049  0.420 29.87370 ? 201 CYS A HB2  1 
ATOM   215  H HB3  A CYS A 1 21  ? -17.28095 24.99493  -7.41988  0.580 29.94154 ? 201 CYS A HB3  1 
ATOM   216  H HB3  B CYS A 1 21  ? -16.53990 25.02350  -7.62416  0.420 29.87370 ? 201 CYS A HB3  1 
ATOM   217  H HG   A CYS A 1 21  ? -18.34411 26.26830  -9.47683  0.580 30.59370 ? 201 CYS A HG   1 
ATOM   218  N N    . MET A 1 22  ? -15.50651 24.49850  -5.10765  1.000 22.71323 ? 202 MET A N    1 
ATOM   219  C CA   . MET A 1 22  ? -15.43931 23.39274  -4.15927  1.000 19.12884 ? 202 MET A CA   1 
ATOM   220  C C    . MET A 1 22  ? -15.27164 23.89441  -2.73217  1.000 19.47406 ? 202 MET A C    1 
ATOM   221  O O    . MET A 1 22  ? -15.86740 23.33946  -1.80191  1.000 23.60608 ? 202 MET A O    1 
ATOM   222  C CB   . MET A 1 22  ? -14.30419 22.44406  -4.53685  1.000 23.93878 ? 202 MET A CB   1 
ATOM   223  C CG   . MET A 1 22  ? -14.41937 21.92438  -5.96097  1.000 18.50145 ? 202 MET A CG   1 
ATOM   224  S SD   . MET A 1 22  ? -15.39827 20.41110  -6.13401  1.000 24.69119 ? 202 MET A SD   1 
ATOM   225  C CE   . MET A 1 22  ? -14.93254 19.44351  -4.69680  1.000 19.86467 ? 202 MET A CE   1 
ATOM   226  H H    . MET A 1 22  ? -14.83112 24.56606  -5.63575  1.000 27.70793 ? 202 MET A H    1 
ATOM   227  H HA   . MET A 1 22  ? -16.26887 22.89293  -4.21324  1.000 20.98066 ? 202 MET A HA   1 
ATOM   228  H HB2  . MET A 1 22  ? -13.45983 22.91469  -4.45644  1.000 29.17859 ? 202 MET A HB2  1 
ATOM   229  H HB3  . MET A 1 22  ? -14.31753 21.68176  -3.93717  1.000 29.17859 ? 202 MET A HB3  1 
ATOM   230  H HG2  . MET A 1 22  ? -14.83930 22.60790  -6.50628  1.000 22.65379 ? 202 MET A HG2  1 
ATOM   231  H HG3  . MET A 1 22  ? -13.52812 21.73546  -6.29397  1.000 22.65379 ? 202 MET A HG3  1 
ATOM   232  H HE1  . MET A 1 22  ? -15.18230 18.51797  -4.84477  1.000 24.28965 ? 202 MET A HE1  1 
ATOM   233  H HE2  . MET A 1 22  ? -13.97348 19.51079  -4.56807  1.000 24.28965 ? 202 MET A HE2  1 
ATOM   234  H HE3  . MET A 1 22  ? -15.39591 19.79081  -3.91862  1.000 24.28965 ? 202 MET A HE3  1 
ATOM   235  N N    . ASN A 1 23  ? -14.47054 24.94277  -2.53377  1.000 25.31588 ? 203 ASN A N    1 
ATOM   236  C CA   . ASN A 1 23  ? -14.24023 25.41903  -1.17453  1.000 25.78688 ? 203 ASN A CA   1 
ATOM   237  C C    . ASN A 1 23  ? -15.47409 26.10597  -0.59824  1.000 31.44358 ? 203 ASN A C    1 
ATOM   238  O O    . ASN A 1 23  ? -15.66587 26.09889  0.62353   1.000 32.88656 ? 203 ASN A O    1 
ATOM   239  C CB   . ASN A 1 23  ? -13.03174 26.35469  -1.14464  1.000 19.44721 ? 203 ASN A CB   1 
ATOM   240  C CG   . ASN A 1 23  ? -11.71941 25.61660  -1.35946  1.000 26.86618 ? 203 ASN A CG   1 
ATOM   241  O OD1  . ASN A 1 23  ? -11.53783 24.49678  -0.87965  1.000 21.50998 ? 203 ASN A OD1  1 
ATOM   242  N ND2  . ASN A 1 23  ? -10.79725 26.24335  -2.08028  1.000 17.20501 ? 203 ASN A ND2  1 
ATOM   243  H H    . ASN A 1 23  ? -14.06194 25.38104  -3.15067  1.000 30.83110 ? 203 ASN A H    1 
ATOM   244  H HA   . ASN A 1 23  ? -14.03838 24.65914  -0.60645  1.000 31.39630 ? 203 ASN A HA   1 
ATOM   245  H HB2  . ASN A 1 23  ? -13.12452 27.01520  -1.84893  1.000 23.78870 ? 203 ASN A HB2  1 
ATOM   246  H HB3  . ASN A 1 23  ? -12.99216 26.79414  -0.28081  1.000 23.78870 ? 203 ASN A HB3  1 
ATOM   247  H HD21 . ASN A 1 23  ? -10.03864 25.86666  -2.22932  1.000 21.09806 ? 203 ASN A HD21 1 
ATOM   248  H HD22 . ASN A 1 23  ? -10.95854 27.02600  -2.39814  1.000 21.09806 ? 203 ASN A HD22 1 
ATOM   249  N N    . LYS A 1 24  ? -16.32776 26.68482  -1.44694  1.000 21.55430 ? 204 LYS A N    1 
ATOM   250  C CA   . LYS A 1 24  ? -17.52342 27.36245  -0.95736  1.000 24.55331 ? 204 LYS A CA   1 
ATOM   251  C C    . LYS A 1 24  ? -18.74097 26.44740  -0.88110  1.000 28.67300 ? 204 LYS A C    1 
ATOM   252  O O    . LYS A 1 24  ? -19.55790 26.58844  0.03532   1.000 31.59492 ? 204 LYS A O    1 
ATOM   253  C CB   . LYS A 1 24  ? -17.85122 28.56283  -1.84898  1.000 27.11443 ? 204 LYS A CB   1 
ATOM   254  C CG   . LYS A 1 24  ? -16.89694 29.73022  -1.69329  1.000 34.90064 ? 204 LYS A CG   1 
ATOM   255  C CD   . LYS A 1 24  ? -17.28483 30.87829  -2.61128  1.000 32.81067 ? 204 LYS A CD   1 
ATOM   256  C CE   . LYS A 1 24  ? -16.51990 32.14738  -2.27752  1.000 28.95794 ? 204 LYS A CE   1 
ATOM   257  N NZ   . LYS A 1 24  ? -16.77840 32.60797  -0.88544  1.000 25.29163 ? 204 LYS A NZ   1 
ATOM   258  H H    . LYS A 1 24  ? -16.23497 26.69703  -2.30184  1.000 23.60492 ? 204 LYS A H    1 
ATOM   259  H HA   . LYS A 1 24  ? -17.33769 27.68365  -0.06112  1.000 29.91602 ? 204 LYS A HA   1 
ATOM   260  H HB2  . LYS A 1 24  ? -17.81990 28.27854  -2.77585  1.000 32.98936 ? 204 LYS A HB2  1 
ATOM   261  H HB3  . LYS A 1 24  ? -18.74146 28.87889  -1.62880  1.000 32.98936 ? 204 LYS A HB3  1 
ATOM   262  H HG2  . LYS A 1 24  ? -16.92198 30.04801  -0.77717  1.000 42.33282 ? 204 LYS A HG2  1 
ATOM   263  H HG3  . LYS A 1 24  ? -15.99814 29.44539  -1.92119  1.000 42.33282 ? 204 LYS A HG3  1 
ATOM   264  H HD2  . LYS A 1 24  ? -17.08591 30.63597  -3.52921  1.000 39.82485 ? 204 LYS A HD2  1 
ATOM   265  H HD3  . LYS A 1 24  ? -18.23265 31.06020  -2.51411  1.000 39.82485 ? 204 LYS A HD3  1 
ATOM   266  H HE2  . LYS A 1 24  ? -15.56889 31.97973  -2.36893  1.000 35.20157 ? 204 LYS A HE2  1 
ATOM   267  H HE3  . LYS A 1 24  ? -16.79231 32.85284  -2.88499  1.000 35.20157 ? 204 LYS A HE3  1 
ATOM   268  H HZ1  . LYS A 1 24  ? -17.65452 32.67970  -0.74629  1.000 30.80201 ? 204 LYS A HZ1  1 
ATOM   269  H HZ2  . LYS A 1 24  ? -16.44041 32.02486  -0.30419  1.000 30.80201 ? 204 LYS A HZ2  1 
ATOM   270  H HZ3  . LYS A 1 24  ? -16.39880 33.40182  -0.75204  1.000 30.80201 ? 204 LYS A HZ3  1 
ATOM   271  N N    . HIS A 1 25  ? -18.88452 25.51211  -1.81879  1.000 28.90540 ? 205 HIS A N    1 
ATOM   272  C CA   . HIS A 1 25  ? -20.07350 24.67999  -1.91819  1.000 28.17695 ? 205 HIS A CA   1 
ATOM   273  C C    . HIS A 1 25  ? -19.79265 23.19383  -1.78407  1.000 26.23401 ? 205 HIS A C    1 
ATOM   274  O O    . HIS A 1 25  ? -20.68745 22.44614  -1.38423  1.000 29.42265 ? 205 HIS A O    1 
ATOM   275  C CB   . HIS A 1 25  ? -20.76989 24.91248  -3.26927  1.000 32.09294 ? 205 HIS A CB   1 
ATOM   276  C CG   . HIS A 1 25  ? -20.97619 26.35632  -3.60586  1.000 31.38895 ? 205 HIS A CG   1 
ATOM   277  N ND1  . HIS A 1 25  ? -21.90563 27.14732  -2.96545  1.000 39.79610 ? 205 HIS A ND1  1 
ATOM   278  C CD2  . HIS A 1 25  ? -20.37037 27.15210  -4.51837  1.000 25.70600 ? 205 HIS A CD2  1 
ATOM   279  C CE1  . HIS A 1 25  ? -21.86392 28.36772  -3.47008  1.000 28.73875 ? 205 HIS A CE1  1 
ATOM   280  N NE2  . HIS A 1 25  ? -20.94038 28.39736  -4.41338  1.000 27.10890 ? 205 HIS A NE2  1 
ATOM   281  H H    . HIS A 1 25  ? -18.29318 25.34004  -2.41905  1.000 35.13852 ? 205 HIS A H    1 
ATOM   282  H HA   . HIS A 1 25  ? -20.68503 24.93416  -1.20943  1.000 34.26438 ? 205 HIS A HA   1 
ATOM   283  H HB2  . HIS A 1 25  ? -20.22671 24.52046  -3.97082  1.000 38.96358 ? 205 HIS A HB2  1 
ATOM   284  H HB3  . HIS A 1 25  ? -21.64130 24.48696  -3.24747  1.000 38.96358 ? 205 HIS A HB3  1 
ATOM   285  H HD2  . HIS A 1 25  ? -19.69457 26.90227  -5.10640  1.000 28.58696 ? 205 HIS A HD2  1 
ATOM   286  H HE1  . HIS A 1 25  ? -22.39480 29.08412  -3.20581  1.000 32.22626 ? 205 HIS A HE1  1 
ATOM   287  H HE2  . HIS A 1 25  ? -20.72994 29.08476  -4.88538  1.000 30.36482 ? 205 HIS A HE2  1 
ATOM   288  N N    . GLY A 1 26  ? -18.58419 22.74543  -2.11191  1.000 23.91718 ? 206 GLY A N    1 
ATOM   289  C CA   . GLY A 1 26  ? -18.28444 21.33329  -2.16130  1.000 28.55793 ? 206 GLY A CA   1 
ATOM   290  C C    . GLY A 1 26  ? -18.79533 20.62598  -3.39442  1.000 27.46051 ? 206 GLY A C    1 
ATOM   291  O O    . GLY A 1 26  ? -18.67704 19.39623  -3.47632  1.000 22.40270 ? 206 GLY A O    1 
ATOM   292  H H    . GLY A 1 26  ? -17.91789 23.25134  -2.31116  1.000 29.15267 ? 206 GLY A H    1 
ATOM   293  H HA2  . GLY A 1 26  ? -17.32188 21.21762  -2.12966  1.000 34.72157 ? 206 GLY A HA2  1 
ATOM   294  H HA3  . GLY A 1 26  ? -18.67979 20.90340  -1.38683  1.000 34.72157 ? 206 GLY A HA3  1 
ATOM   295  N N    . ILE A 1 27  ? -19.37474 21.35625  -4.34394  1.000 22.95349 ? 207 ILE A N    1 
ATOM   296  C CA   . ILE A 1 27  ? -19.87260 20.79620  -5.59423  1.000 25.66752 ? 207 ILE A CA   1 
ATOM   297  C C    . ILE A 1 27  ? -19.53167 21.76768  -6.71520  1.000 24.20610 ? 207 ILE A C    1 
ATOM   298  O O    . ILE A 1 27  ? -19.68526 22.98405  -6.56400  1.000 23.04294 ? 207 ILE A O    1 
ATOM   299  C CB   . ILE A 1 27  ? -21.39241 20.53491  -5.54256  1.000 24.99158 ? 207 ILE A CB   1 
ATOM   300  C CG1  . ILE A 1 27  ? -21.73162 19.53547  -4.43305  1.000 26.16056 ? 207 ILE A CG1  1 
ATOM   301  C CG2  . ILE A 1 27  ? -21.88682 20.01969  -6.88599  1.000 29.42321 ? 207 ILE A CG2  1 
ATOM   302  C CD1  . ILE A 1 27  ? -23.19363 19.52942  -4.04247  1.000 35.62488 ? 207 ILE A CD1  1 
ATOM   303  H H    . ILE A 1 27  ? -19.49402 22.20580  -4.28363  1.000 25.28394 ? 207 ILE A H    1 
ATOM   304  H HA   . ILE A 1 27  ? -19.42904 19.95094  -5.76656  1.000 31.25308 ? 207 ILE A HA   1 
ATOM   305  H HB   . ILE A 1 27  ? -21.83692 21.37429  -5.34572  1.000 29.66435 ? 207 ILE A HB   1 
ATOM   306  H HG12 . ILE A 1 27  ? -21.50284 18.64310  -4.73676  1.000 31.84472 ? 207 ILE A HG12 1 
ATOM   307  H HG13 . ILE A 1 27  ? -21.21527 19.75962  -3.64309  1.000 31.84472 ? 207 ILE A HG13 1 
ATOM   308  H HG21 . ILE A 1 27  ? -22.78788 19.67642  -6.78037  1.000 35.75990 ? 207 ILE A HG21 1 
ATOM   309  H HG22 . ILE A 1 27  ? -21.88371 20.74968  -7.52474  1.000 35.75990 ? 207 ILE A HG22 1 
ATOM   310  H HG23 . ILE A 1 27  ? -21.29675 19.31213  -7.18943  1.000 35.75990 ? 207 ILE A HG23 1 
ATOM   311  H HD11 . ILE A 1 27  ? -23.30877 18.96984  -3.25856  1.000 43.20191 ? 207 ILE A HD11 1 
ATOM   312  H HD12 . ILE A 1 27  ? -23.47134 20.43746  -3.84436  1.000 43.20191 ? 207 ILE A HD12 1 
ATOM   313  H HD13 . ILE A 1 27  ? -23.71608 19.17718  -4.77995  1.000 43.20191 ? 207 ILE A HD13 1 
ATOM   314  N N    . CYS A 1 28  ? -19.06618 21.22883  -7.83963  1.000 21.82060 ? 208 CYS A N    1 
ATOM   315  C CA   . CYS A 1 28  ? -18.69216 22.03381  -8.99414  1.000 24.19101 ? 208 CYS A CA   1 
ATOM   316  C C    . CYS A 1 28  ? -19.12573 21.32820  -10.26857 1.000 22.59445 ? 208 CYS A C    1 
ATOM   317  O O    . CYS A 1 28  ? -18.90775 20.12298  -10.42148 1.000 21.81968 ? 208 CYS A O    1 
ATOM   318  C CB   . CYS A 1 28  ? -17.18163 22.28888  -9.03161  1.000 23.64660 ? 208 CYS A CB   1 
ATOM   319  S SG   . CYS A 1 28  ? -16.64484 23.29079  -10.43620 1.000 23.63752 ? 208 CYS A SG   1 
ATOM   320  H H    . CYS A 1 28  ? -18.95683 20.38408  -7.95815  1.000 24.66010 ? 208 CYS A H    1 
ATOM   321  H HA   . CYS A 1 28  ? -19.15096 22.88705  -8.94533  1.000 29.48126 ? 208 CYS A HA   1 
ATOM   322  H HB2  . CYS A 1 28  ? -16.92423 22.75446  -8.22051  1.000 28.82796 ? 208 CYS A HB2  1 
ATOM   323  H HB3  . CYS A 1 28  ? -16.72299 21.43578  -9.08423  1.000 28.82796 ? 208 CYS A HB3  1 
ATOM   324  H HG   . CYS A 1 28  ? -17.18123 24.36272  -10.37915 1.000 28.81707 ? 208 CYS A HG   1 
ATOM   325  N N    . VAL A 1 29  ? -19.72262 22.08516  -11.18514 1.000 25.71991 ? 209 VAL A N    1 
ATOM   326  C CA   . VAL A 1 29  ? -20.20967 21.56288  -12.45639 1.000 36.17045 ? 209 VAL A CA   1 
ATOM   327  C C    . VAL A 1 29  ? -19.53415 22.33213  -13.58285 1.000 30.35475 ? 209 VAL A C    1 
ATOM   328  O O    . VAL A 1 29  ? -19.52062 23.56864  -13.57664 1.000 32.86687 ? 209 VAL A O    1 
ATOM   329  C CB   . VAL A 1 29  ? -21.74214 21.66948  -12.56582 1.000 27.15098 ? 209 VAL A CB   1 
ATOM   330  C CG1  . VAL A 1 29  ? -22.20540 21.28642  -13.96637 1.000 27.02072 ? 209 VAL A CG1  1 
ATOM   331  C CG2  . VAL A 1 29  ? -22.41277 20.79348  -11.51766 1.000 25.73016 ? 209 VAL A CG2  1 
ATOM   332  H H    . VAL A 1 29  ? -19.86018 22.92865  -11.08920 1.000 31.31594 ? 209 VAL A H    1 
ATOM   333  H HA   . VAL A 1 29  ? -19.96147 20.62830  -12.53291 1.000 43.85658 ? 209 VAL A HA   1 
ATOM   334  H HB   . VAL A 1 29  ? -22.00582 22.58868  -12.40323 1.000 33.03322 ? 209 VAL A HB   1 
ATOM   335  H HG11 . VAL A 1 29  ? -23.15914 21.11070  -13.94650 1.000 32.87691 ? 209 VAL A HG11 1 
ATOM   336  H HG12 . VAL A 1 29  ? -22.01668 22.01947  -14.57294 1.000 32.87691 ? 209 VAL A HG12 1 
ATOM   337  H HG13 . VAL A 1 29  ? -21.72835 20.49099  -14.25027 1.000 32.87691 ? 209 VAL A HG13 1 
ATOM   338  H HG21 . VAL A 1 29  ? -23.37523 20.87223  -11.60914 1.000 30.47085 ? 209 VAL A HG21 1 
ATOM   339  H HG22 . VAL A 1 29  ? -22.14166 19.87239  -11.65551 1.000 30.47085 ? 209 VAL A HG22 1 
ATOM   340  H HG23 . VAL A 1 29  ? -22.13892 21.09044  -10.63577 1.000 30.47085 ? 209 VAL A HG23 1 
ATOM   341  N N    . VAL A 1 30  ? -18.97921 21.59881  -14.54528 1.000 24.92195 ? 210 VAL A N    1 
ATOM   342  C CA   . VAL A 1 30  ? -18.29587 22.16411  -15.70437 1.000 23.04121 ? 210 VAL A CA   1 
ATOM   343  C C    . VAL A 1 30  ? -18.95842 21.54871  -16.93059 1.000 28.42551 ? 210 VAL A C    1 
ATOM   344  O O    . VAL A 1 30  ? -18.69968 20.38712  -17.26573 1.000 28.14477 ? 210 VAL A O    1 
ATOM   345  C CB   . VAL A 1 30  ? -16.78976 21.87986  -15.69118 1.000 30.42493 ? 210 VAL A CB   1 
ATOM   346  C CG1  . VAL A 1 30  ? -16.13612 22.40027  -16.96376 1.000 28.39171 ? 210 VAL A CG1  1 
ATOM   347  C CG2  . VAL A 1 30  ? -16.13948 22.48648  -14.45687 1.000 23.09770 ? 210 VAL A CG2  1 
ATOM   348  H H    . VAL A 1 30  ? -18.98664 20.73885  -14.54781 1.000 30.35839 ? 210 VAL A H    1 
ATOM   349  H HA   . VAL A 1 30  ? -18.42629 23.12507  -15.72557 1.000 28.10150 ? 210 VAL A HA   1 
ATOM   350  H HB   . VAL A 1 30  ? -16.65263 20.92022  -15.65677 1.000 36.96196 ? 210 VAL A HB   1 
ATOM   351  H HG11 . VAL A 1 30  ? -15.17299 22.39596  -16.84860 1.000 34.52210 ? 210 VAL A HG11 1 
ATOM   352  H HG12 . VAL A 1 30  ? -16.38333 21.82430  -17.70405 1.000 34.52210 ? 210 VAL A HG12 1 
ATOM   353  H HG13 . VAL A 1 30  ? -16.44527 23.30443  -17.13058 1.000 34.52210 ? 210 VAL A HG13 1 
ATOM   354  H HG21 . VAL A 1 30  ? -15.19516 22.26476  -14.45617 1.000 28.16929 ? 210 VAL A HG21 1 
ATOM   355  H HG22 . VAL A 1 30  ? -16.25313 23.44949  -14.48105 1.000 28.16929 ? 210 VAL A HG22 1 
ATOM   356  H HG23 . VAL A 1 30  ? -16.56519 22.12296  -13.66470 1.000 28.16929 ? 210 VAL A HG23 1 
ATOM   357  N N    . ASP A 1 31  ? -19.81033 22.31653  -17.60139 1.000 30.45513 ? 211 ASP A N    1 
ATOM   358  C CA   . ASP A 1 31  ? -20.53380 21.83008  -18.76630 1.000 29.14497 ? 211 ASP A CA   1 
ATOM   359  C C    . ASP A 1 31  ? -19.70566 22.02717  -20.03041 1.000 26.70198 ? 211 ASP A C    1 
ATOM   360  O O    . ASP A 1 31  ? -18.84241 22.90555  -20.10138 1.000 25.12505 ? 211 ASP A O    1 
ATOM   361  C CB   . ASP A 1 31  ? -21.87752 22.54762  -18.90345 1.000 37.31501 ? 211 ASP A CB   1 
ATOM   362  C CG   . ASP A 1 31  ? -22.93673 21.98183  -17.97730 1.000 37.94236 ? 211 ASP A CG   1 
ATOM   363  O OD1  . ASP A 1 31  ? -22.92173 20.75720  -17.73257 1.000 32.26241 ? 211 ASP A OD1  1 
ATOM   364  O OD2  . ASP A 1 31  ? -23.78610 22.76046  -17.49583 1.000 41.75932 ? 211 ASP A OD2  1 
ATOM   365  H H    . ASP A 1 31  ? -19.98765 23.13302  -17.39770 1.000 36.99820 ? 211 ASP A H    1 
ATOM   366  H HA   . ASP A 1 31  ? -20.70760 20.88117  -18.66494 1.000 35.42601 ? 211 ASP A HA   1 
ATOM   367  H HB2  . ASP A 1 31  ? -21.75918 23.48581  -18.68737 1.000 45.23006 ? 211 ASP A HB2  1 
ATOM   368  H HB3  . ASP A 1 31  ? -22.19469 22.45465  -19.81540 1.000 45.23006 ? 211 ASP A HB3  1 
ATOM   369  N N    . ASP A 1 32  ? -19.98305 21.19621  -21.03424 1.000 27.88621 ? 212 ASP A N    1 
ATOM   370  C CA   . ASP A 1 32  ? -19.23298 21.19892  -22.28919 1.000 26.41589 ? 212 ASP A CA   1 
ATOM   371  C C    . ASP A 1 32  ? -17.73469 21.09959  -22.01034 1.000 29.41208 ? 212 ASP A C    1 
ATOM   372  O O    . ASP A 1 32  ? -16.92734 21.92473  -22.44766 1.000 24.84959 ? 212 ASP A O    1 
ATOM   373  C CB   . ASP A 1 32  ? -19.56650 22.43944  -23.11799 1.000 32.38697 ? 212 ASP A CB   1 
ATOM   374  C CG   . ASP A 1 32  ? -21.04001 22.52853  -23.46364 1.000 34.54324 ? 212 ASP A CG   1 
ATOM   375  O OD1  . ASP A 1 32  ? -21.52713 21.66381  -24.22309 1.000 42.80366 ? 212 ASP A OD1  1 
ATOM   376  O OD2  . ASP A 1 32  ? -21.71192 23.46046  -22.97395 1.000 37.83262 ? 212 ASP A OD2  1 
ATOM   377  H H    . ASP A 1 32  ? -20.61274 20.61089  -21.01195 1.000 33.91551 ? 212 ASP A H    1 
ATOM   378  H HA   . ASP A 1 32  ? -19.48775 20.42242  -22.81173 1.000 31.51615 ? 212 ASP A HA   1 
ATOM   379  H HB2  . ASP A 1 32  ? -19.32762 23.23204  -22.61239 1.000 39.31641 ? 212 ASP A HB2  1 
ATOM   380  H HB3  . ASP A 1 32  ? -19.06413 22.41103  -23.94728 1.000 39.31641 ? 212 ASP A HB3  1 
ATOM   381  N N    . PHE A 1 33  ? -17.37382 20.05818  -21.25908 1.000 23.70868 ? 213 PHE A N    1 
ATOM   382  C CA   . PHE A 1 33  ? -16.00440 19.91418  -20.77853 1.000 22.30258 ? 213 PHE A CA   1 
ATOM   383  C C    . PHE A 1 33  ? -15.04089 19.60515  -21.91941 1.000 31.23442 ? 213 PHE A C    1 
ATOM   384  O O    . PHE A 1 33  ? -13.97184 20.21886  -22.02235 1.000 25.06292 ? 213 PHE A O    1 
ATOM   385  C CB   . PHE A 1 33  ? -15.95099 18.82118  -19.70780 1.000 30.27158 ? 213 PHE A CB   1 
ATOM   386  C CG   . PHE A 1 33  ? -14.56178 18.48792  -19.24160 1.000 33.14630 ? 213 PHE A CG   1 
ATOM   387  C CD1  . PHE A 1 33  ? -13.65330 19.49049  -18.94758 1.000 23.99584 ? 213 PHE A CD1  1 
ATOM   388  C CD2  . PHE A 1 33  ? -14.16807 17.16903  -19.08882 1.000 19.97257 ? 213 PHE A CD2  1 
ATOM   389  C CE1  . PHE A 1 33  ? -12.37798 19.18371  -18.51781 1.000 26.57957 ? 213 PHE A CE1  1 
ATOM   390  C CE2  . PHE A 1 33  ? -12.89412 16.85714  -18.66074 1.000 34.05207 ? 213 PHE A CE2  1 
ATOM   391  C CZ   . PHE A 1 33  ? -11.99817 17.86572  -18.37370 1.000 18.56170 ? 213 PHE A CZ   1 
ATOM   392  H H    . PHE A 1 33  ? -17.90175 19.42455  -21.01538 1.000 28.43043 ? 213 PHE A H    1 
ATOM   393  H HA   . PHE A 1 33  ? -15.72142 20.75083  -20.37748 1.000 26.27979 ? 213 PHE A HA   1 
ATOM   394  H HB2  . PHE A 1 33  ? -16.45791 19.11750  -18.93571 1.000 36.77795 ? 213 PHE A HB2  1 
ATOM   395  H HB3  . PHE A 1 33  ? -16.34240 18.01125  -20.07073 1.000 36.77795 ? 213 PHE A HB3  1 
ATOM   396  H HD1  . PHE A 1 33  ? -13.90522 20.38086  -19.04071 1.000 29.24705 ? 213 PHE A HD1  1 
ATOM   397  H HD2  . PHE A 1 33  ? -14.76971 16.48529  -19.27707 1.000 24.35417 ? 213 PHE A HD2  1 
ATOM   398  H HE1  . PHE A 1 33  ? -11.77521 19.86532  -18.32555 1.000 32.34753 ? 213 PHE A HE1  1 
ATOM   399  H HE2  . PHE A 1 33  ? -12.63973 15.96766  -18.56582 1.000 41.31453 ? 213 PHE A HE2  1 
ATOM   400  H HZ   . PHE A 1 33  ? -11.13951 17.65743  -18.08350 1.000 21.15446 ? 213 PHE A HZ   1 
ATOM   401  N N    . LEU A 1 34  ? -15.40036 18.65779  -22.79121 1.000 32.05450 ? 214 LEU A N    1 
ATOM   402  C CA   . LEU A 1 34  ? -14.49732 18.19063  -23.83402 1.000 30.85594 ? 214 LEU A CA   1 
ATOM   403  C C    . LEU A 1 34  ? -14.96392 18.50026  -25.24820 1.000 31.55655 ? 214 LEU A C    1 
ATOM   404  O O    . LEU A 1 34  ? -14.15424 18.40663  -26.17758 1.000 33.63907 ? 214 LEU A O    1 
ATOM   405  C CB   . LEU A 1 34  ? -14.28842 16.67219  -23.71409 1.000 30.30328 ? 214 LEU A CB   1 
ATOM   406  C CG   . LEU A 1 34  ? -13.50702 16.18132  -22.49310 1.000 23.77145 ? 214 LEU A CG   1 
ATOM   407  C CD1  . LEU A 1 34  ? -13.42601 14.65943  -22.48188 1.000 29.48973 ? 214 LEU A CD1  1 
ATOM   408  C CD2  . LEU A 1 34  ? -12.11238 16.79089  -22.44878 1.000 29.45700 ? 214 LEU A CD2  1 
ATOM   409  H H    . LEU A 1 34  ? -16.16835 18.27079  -22.79493 1.000 38.91744 ? 214 LEU A H    1 
ATOM   410  H HA   . LEU A 1 34  ? -13.63833 18.62395  -23.71044 1.000 37.47917 ? 214 LEU A HA   1 
ATOM   411  H HB2  . LEU A 1 34  ? -15.16160 16.25104  -23.68111 1.000 36.81599 ? 214 LEU A HB2  1 
ATOM   412  H HB3  . LEU A 1 34  ? -13.80524 16.37295  -24.50014 1.000 36.81599 ? 214 LEU A HB3  1 
ATOM   413  H HG   . LEU A 1 34  ? -13.97769 16.46607  -21.69417 1.000 28.97778 ? 214 LEU A HG   1 
ATOM   414  H HD11 . LEU A 1 34  ? -12.92490 14.37560  -21.70135 1.000 35.83972 ? 214 LEU A HD11 1 
ATOM   415  H HD12 . LEU A 1 34  ? -14.32456 14.29558  -22.44839 1.000 35.83972 ? 214 LEU A HD12 1 
ATOM   416  H HD13 . LEU A 1 34  ? -12.97820 14.36106  -23.28894 1.000 35.83972 ? 214 LEU A HD13 1 
ATOM   417  H HD21 . LEU A 1 34  ? -11.59106 16.33752  -21.76792 1.000 35.80045 ? 214 LEU A HD21 1 
ATOM   418  H HD22 . LEU A 1 34  ? -11.69169 16.68029  -23.31578 1.000 35.80045 ? 214 LEU A HD22 1 
ATOM   419  H HD23 . LEU A 1 34  ? -12.18666 17.73414  -22.23508 1.000 35.80045 ? 214 LEU A HD23 1 
ATOM   420  N N    . GLY A 1 35  ? -16.22526 18.86192  -25.43942 1.000 32.77857 ? 215 GLY A N    1 
ATOM   421  C CA   . GLY A 1 35  ? -16.75651 19.11156  -26.76041 1.000 34.02343 ? 215 GLY A CA   1 
ATOM   422  C C    . GLY A 1 35  ? -17.59566 17.94977  -27.26879 1.000 43.58096 ? 215 GLY A C    1 
ATOM   423  O O    . GLY A 1 35  ? -17.55454 16.83183  -26.74912 1.000 36.07161 ? 215 GLY A O    1 
ATOM   424  H H    . GLY A 1 35  ? -16.79817 18.96977  -24.80717 1.000 39.78633 ? 215 GLY A H    1 
ATOM   425  H HA2  . GLY A 1 35  ? -17.31303 19.90575  -26.73908 1.000 41.28017 ? 215 GLY A HA2  1 
ATOM   426  H HA3  . GLY A 1 35  ? -16.02438 19.25552  -27.38021 1.000 41.28017 ? 215 GLY A HA3  1 
ATOM   427  N N    . LYS A 1 36  ? -18.37397 18.22968  -28.31682 1.000 38.59018 ? 216 LYS A N    1 
ATOM   428  C CA   . LYS A 1 36  ? -19.30437 17.23110  -28.83409 1.000 39.28289 ? 216 LYS A CA   1 
ATOM   429  C C    . LYS A 1 36  ? -18.56556 16.02491  -29.40069 1.000 41.83472 ? 216 LYS A C    1 
ATOM   430  O O    . LYS A 1 36  ? -18.94369 14.87558  -29.14192 1.000 43.46809 ? 216 LYS A O    1 
ATOM   431  C CB   . LYS A 1 36  ? -20.20216 17.85748  -29.90152 1.000 39.61067 ? 216 LYS A CB   1 
ATOM   432  C CG   . LYS A 1 36  ? -21.46952 17.06420  -30.17488 1.000 39.83051 ? 216 LYS A CG   1 
ATOM   433  C CD   . LYS A 1 36  ? -22.42036 17.82480  -31.08476 1.000 41.31022 ? 216 LYS A CD   1 
ATOM   434  H H    . LYS A 1 36  ? -18.38144 18.97899  -28.73881 1.000 44.04797 ? 216 LYS A H    1 
ATOM   435  H HA   . LYS A 1 36  ? -19.86705 16.92314  -28.10646 1.000 47.59152 ? 216 LYS A HA   1 
ATOM   436  H HB2  . LYS A 1 36  ? -20.46469 18.74385  -29.60770 1.000 45.27256 ? 216 LYS A HB2  1 
ATOM   437  H HB3  . LYS A 1 36  ? -19.70468 17.91709  -30.73209 1.000 45.27256 ? 216 LYS A HB3  1 
ATOM   438  H HG2  . LYS A 1 36  ? -21.23749 16.22781  -30.60792 1.000 45.53637 ? 216 LYS A HG2  1 
ATOM   439  H HG3  . LYS A 1 36  ? -21.92527 16.88861  -29.33681 1.000 45.53637 ? 216 LYS A HG3  1 
ATOM   440  N N    . GLU A 1 37  ? -17.50872 16.26630  -30.17819 1.000 44.09556 ? 217 GLU A N    1 
ATOM   441  C CA   . GLU A 1 37  ? -16.78365 15.16983  -30.81143 1.000 45.52584 ? 217 GLU A CA   1 
ATOM   442  C C    . GLU A 1 37  ? -16.23860 14.20135  -29.76906 1.000 40.19879 ? 217 GLU A C    1 
ATOM   443  O O    . GLU A 1 37  ? -16.61127 13.02172  -29.74373 1.000 44.76445 ? 217 GLU A O    1 
ATOM   444  C CB   . GLU A 1 37  ? -15.65009 15.72382  -31.67802 1.000 39.49909 ? 217 GLU A CB   1 
ATOM   445  C CG   . GLU A 1 37  ? -14.72809 14.65775  -32.25216 1.000 39.58267 ? 217 GLU A CG   1 
ATOM   446  H H    . GLU A 1 37  ? -17.19576 17.04819  -30.35224 1.000 53.36672 ? 217 GLU A H    1 
ATOM   447  H HA   . GLU A 1 37  ? -17.39456 14.68352  -31.38693 1.000 55.08306 ? 217 GLU A HA   1 
ATOM   448  H HB2  . GLU A 1 37  ? -16.03775 16.21002  -32.42249 1.000 45.13867 ? 217 GLU A HB2  1 
ATOM   449  H HB3  . GLU A 1 37  ? -15.10946 16.32077  -31.13741 1.000 45.13867 ? 217 GLU A HB3  1 
ATOM   450  N N    . THR A 1 38  ? -15.34736 14.68823  -28.90078 1.000 38.20594 ? 218 THR A N    1 
ATOM   451  C CA   . THR A 1 38  ? -14.71307 13.81949  -27.91419 1.000 36.87615 ? 218 THR A CA   1 
ATOM   452  C C    . THR A 1 38  ? -15.75052 13.12806  -27.03923 1.000 36.45036 ? 218 THR A C    1 
ATOM   453  O O    . THR A 1 38  ? -15.58684 11.95650  -26.67583 1.000 38.70624 ? 218 THR A O    1 
ATOM   454  C CB   . THR A 1 38  ? -13.73966 14.63103  -27.05879 1.000 36.46526 ? 218 THR A CB   1 
ATOM   455  O OG1  . THR A 1 38  ? -12.75062 15.23327  -27.90341 1.000 36.97930 ? 218 THR A OG1  1 
ATOM   456  C CG2  . THR A 1 38  ? -13.05011 13.74300  -26.03446 1.000 36.06392 ? 218 THR A CG2  1 
ATOM   457  H H    . THR A 1 38  ? -15.09637 15.50996  -28.86393 1.000 46.29917 ? 218 THR A H    1 
ATOM   458  H HA   . THR A 1 38  ? -14.20843 13.13223  -28.37669 1.000 41.99114 ? 218 THR A HA   1 
ATOM   459  H HB   . THR A 1 38  ? -14.22807 15.32065  -26.58258 1.000 44.01260 ? 218 THR A HB   1 
ATOM   460  H HG1  . THR A 1 38  ? -12.21126 15.68073  -27.44031 1.000 42.11492 ? 218 THR A HG1  1 
ATOM   461  H HG21 . THR A 1 38  ? -12.32510 14.22765  -25.60975 1.000 43.72875 ? 218 THR A HG21 1 
ATOM   462  H HG22 . THR A 1 38  ? -13.68442 13.46624  -25.35479 1.000 43.72875 ? 218 THR A HG22 1 
ATOM   463  H HG23 . THR A 1 38  ? -12.68958 12.95402  -26.46854 1.000 43.72875 ? 218 THR A HG23 1 
ATOM   464  N N    . GLY A 1 39  ? -16.82173 13.83720  -26.68296 1.000 36.54966 ? 219 GLY A N    1 
ATOM   465  C CA   . GLY A 1 39  ? -17.89691 13.19774  -25.94479 1.000 36.31504 ? 219 GLY A CA   1 
ATOM   466  C C    . GLY A 1 39  ? -18.50691 12.03891  -26.70898 1.000 36.70753 ? 219 GLY A C    1 
ATOM   467  O O    . GLY A 1 39  ? -18.80069 10.98784  -26.13429 1.000 42.29595 ? 219 GLY A O    1 
ATOM   468  H H    . GLY A 1 39  ? -16.94434 14.67102  -26.85417 1.000 41.59935 ? 219 GLY A H    1 
ATOM   469  H HA2  . GLY A 1 39  ? -17.55326 12.86210  -25.10208 1.000 41.31780 ? 219 GLY A HA2  1 
ATOM   470  H HA3  . GLY A 1 39  ? -18.59445 13.84740  -25.76509 1.000 41.31780 ? 219 GLY A HA3  1 
ATOM   471  N N    . GLN A 1 40  ? -18.69989 12.21286  -28.01868 1.000 37.42378 ? 220 GLN A N    1 
ATOM   472  C CA   . GLN A 1 40  ? -19.24543 11.13514  -28.83706 1.000 40.29014 ? 220 GLN A CA   1 
ATOM   473  C C    . GLN A 1 40  ? -18.29358 9.94581   -28.89621 1.000 43.79583 ? 220 GLN A C    1 
ATOM   474  O O    . GLN A 1 40  ? -18.73225 8.79194   -28.83003 1.000 42.39955 ? 220 GLN A O    1 
ATOM   475  C CB   . GLN A 1 40  ? -19.54691 11.64903  -30.24423 1.000 38.79104 ? 220 GLN A CB   1 
ATOM   476  H H    . GLN A 1 40  ? -18.52501 12.93593  -28.45017 1.000 44.67797 ? 220 GLN A H    1 
ATOM   477  H HA   . GLN A 1 40  ? -20.07746 10.83359  -28.43994 1.000 48.80022 ? 220 GLN A HA   1 
ATOM   478  N N    . GLN A 1 41  ? -16.98897 10.20165  -29.03622 1.000 37.54383 ? 221 GLN A N    1 
ATOM   479  C CA   . GLN A 1 41  ? -16.03476 9.09085   -29.02581 1.000 41.94296 ? 221 GLN A CA   1 
ATOM   480  C C    . GLN A 1 41  ? -16.07132 8.34972   -27.69206 1.000 40.69367 ? 221 GLN A C    1 
ATOM   481  O O    . GLN A 1 41  ? -16.02941 7.11213   -27.65661 1.000 36.70314 ? 221 GLN A O    1 
ATOM   482  C CB   . GLN A 1 41  ? -14.60400 9.56063   -29.31311 1.000 45.24978 ? 221 GLN A CB   1 
ATOM   483  C CG   . GLN A 1 41  ? -14.28865 9.90623   -30.76769 1.000 46.98890 ? 221 GLN A CG   1 
ATOM   484  C CD   . GLN A 1 41  ? -13.84091 11.34146  -30.95997 1.000 65.37754 ? 221 GLN A CD   1 
ATOM   485  O OE1  . GLN A 1 41  ? -14.56928 12.27377  -30.65901 1.000 65.20380 ? 221 GLN A OE1  1 
ATOM   486  N NE2  . GLN A 1 41  ? -12.62499 11.52002  -31.45659 1.000 72.67863 ? 221 GLN A NE2  1 
ATOM   487  H H    . GLN A 1 41  ? -16.64246 10.98248  -29.13537 1.000 42.79235 ? 221 GLN A H    1 
ATOM   488  H HA   . GLN A 1 41  ? -16.28924 8.48619   -29.74032 1.000 50.78360 ? 221 GLN A HA   1 
ATOM   489  H HB2  . GLN A 1 41  ? -14.43589 10.35792  -28.78683 1.000 54.75178 ? 221 GLN A HB2  1 
ATOM   490  H HB3  . GLN A 1 41  ? -13.99460 8.85386   -29.04851 1.000 54.75178 ? 221 GLN A HB3  1 
ATOM   491  H HG2  . GLN A 1 41  ? -13.57560 9.32768   -31.08033 1.000 56.83873 ? 221 GLN A HG2  1 
ATOM   492  H HG3  . GLN A 1 41  ? -15.08593 9.76904   -31.30289 1.000 56.83873 ? 221 GLN A HG3  1 
ATOM   493  H HE21 . GLN A 1 41  ? -12.13586 10.83996  -31.65120 1.000 87.66640 ? 221 GLN A HE21 1 
ATOM   494  H HE22 . GLN A 1 41  ? -12.32523 12.31592  -31.58418 1.000 87.66640 ? 221 GLN A HE22 1 
ATOM   495  N N    . ILE A 1 42  ? -16.13369 9.08845   -26.58171 1.000 36.93777 ? 222 ILE A N    1 
ATOM   496  C CA   . ILE A 1 42  ? -16.18296 8.44100   -25.27336 1.000 37.88914 ? 222 ILE A CA   1 
ATOM   497  C C    . ILE A 1 42  ? -17.44959 7.60483   -25.14699 1.000 40.98156 ? 222 ILE A C    1 
ATOM   498  O O    . ILE A 1 42  ? -17.42338 6.48212   -24.62633 1.000 38.20573 ? 222 ILE A O    1 
ATOM   499  C CB   . ILE A 1 42  ? -16.08009 9.48870   -24.14995 1.000 37.82744 ? 222 ILE A CB   1 
ATOM   500  C CG1  . ILE A 1 42  ? -14.71550 10.17824  -24.20049 1.000 34.58991 ? 222 ILE A CG1  1 
ATOM   501  C CG2  . ILE A 1 42  ? -16.29347 8.83059   -22.79355 1.000 38.70546 ? 222 ILE A CG2  1 
ATOM   502  C CD1  . ILE A 1 42  ? -14.60151 11.39921  -23.31107 1.000 34.24887 ? 222 ILE A CD1  1 
ATOM   503  H H    . ILE A 1 42  ? -16.14838 9.94806   -26.56029 1.000 44.77737 ? 222 ILE A H    1 
ATOM   504  H HA   . ILE A 1 42  ? -15.42044 7.84667   -25.19439 1.000 45.91902 ? 222 ILE A HA   1 
ATOM   505  H HB   . ILE A 1 42  ? -16.77171 10.15585  -24.28214 1.000 45.84497 ? 222 ILE A HB   1 
ATOM   506  H HG12 . ILE A 1 42  ? -14.03748 9.54464   -23.91811 1.000 39.24765 ? 222 ILE A HG12 1 
ATOM   507  H HG13 . ILE A 1 42  ? -14.54525 10.46197  -25.11231 1.000 39.24765 ? 222 ILE A HG13 1 
ATOM   508  H HG21 . ILE A 1 42  ? -16.02075 9.44778   -22.09669 1.000 46.89860 ? 222 ILE A HG21 1 
ATOM   509  H HG22 . ILE A 1 42  ? -17.23318 8.61222   -22.69282 1.000 46.89860 ? 222 ILE A HG22 1 
ATOM   510  H HG23 . ILE A 1 42  ? -15.75923 8.02230   -22.74717 1.000 46.89860 ? 222 ILE A HG23 1 
ATOM   511  H HD11 . ILE A 1 42  ? -13.78859 11.87853  -23.53539 1.000 41.38437 ? 222 ILE A HD11 1 
ATOM   512  H HD12 . ILE A 1 42  ? -15.37261 11.96930  -23.45698 1.000 41.38437 ? 222 ILE A HD12 1 
ATOM   513  H HD13 . ILE A 1 42  ? -14.57203 11.11338  -22.38461 1.000 41.38437 ? 222 ILE A HD13 1 
ATOM   514  N N    . GLY A 1 43  ? -18.57989 8.14311   -25.60728 1.000 36.18158 ? 223 GLY A N    1 
ATOM   515  C CA   . GLY A 1 43  ? -19.81310 7.37539   -25.58563 1.000 45.66238 ? 223 GLY A CA   1 
ATOM   516  C C    . GLY A 1 43  ? -19.72494 6.11445   -26.42264 1.000 41.89426 ? 223 GLY A C    1 
ATOM   517  O O    . GLY A 1 43  ? -20.22918 5.06044   -26.02969 1.000 48.55469 ? 223 GLY A O    1 
ATOM   518  H H    . GLY A 1 43  ? -18.65434 8.93651   -25.93064 1.000 41.15766 ? 223 GLY A H    1 
ATOM   519  H HA2  . GLY A 1 43  ? -20.01703 7.12181   -24.67184 1.000 55.24690 ? 223 GLY A HA2  1 
ATOM   520  H HA3  . GLY A 1 43  ? -20.53680 7.92122   -25.93090 1.000 55.24690 ? 223 GLY A HA3  1 
ATOM   521  N N    . ASP A 1 44  ? -19.08909 6.20613   -27.59280 1.000 45.33846 ? 224 ASP A N    1 
ATOM   522  C CA   . ASP A 1 44  ? -18.91077 5.02277   -28.42753 1.000 45.82302 ? 224 ASP A CA   1 
ATOM   523  C C    . ASP A 1 44  ? -18.07303 3.96956   -27.71803 1.000 37.74502 ? 224 ASP A C    1 
ATOM   524  O O    . ASP A 1 44  ? -18.39188 2.77760   -27.76576 1.000 42.66159 ? 224 ASP A O    1 
ATOM   525  C CB   . ASP A 1 44  ? -18.25416 5.40055   -29.75330 1.000 44.92248 ? 224 ASP A CB   1 
ATOM   526  C CG   . ASP A 1 44  ? -19.23899 5.95135   -30.75420 1.000 47.48201 ? 224 ASP A CG   1 
ATOM   527  O OD1  . ASP A 1 44  ? -20.45149 5.97700   -30.45625 1.000 58.75118 ? 224 ASP A OD1  1 
ATOM   528  O OD2  . ASP A 1 44  ? -18.79828 6.35143   -31.85068 1.000 51.99521 ? 224 ASP A OD2  1 
ATOM   529  H H    . ASP A 1 44  ? -18.75794 6.92963   -27.91912 1.000 54.85820 ? 224 ASP A H    1 
ATOM   530  H HA   . ASP A 1 44  ? -19.78541 4.64826   -28.61629 1.000 55.43967 ? 224 ASP A HA   1 
ATOM   531  H HB2  . ASP A 1 44  ? -17.58028 6.07901   -29.59058 1.000 54.35902 ? 224 ASP A HB2  1 
ATOM   532  H HB3  . ASP A 1 44  ? -17.84361 4.61103   -30.13930 1.000 54.35902 ? 224 ASP A HB3  1 
ATOM   533  N N    . GLU A 1 45  ? -16.98573 4.38630   -27.06912 1.000 36.99645 ? 225 GLU A N    1 
ATOM   534  C CA   . GLU A 1 45  ? -16.15124 3.42155   -26.35739 1.000 38.16633 ? 225 GLU A CA   1 
ATOM   535  C C    . GLU A 1 45  ? -16.91405 2.78697   -25.19807 1.000 40.29101 ? 225 GLU A C    1 
ATOM   536  O O    . GLU A 1 45  ? -16.80249 1.57724   -24.95390 1.000 39.95583 ? 225 GLU A O    1 
ATOM   537  C CB   . GLU A 1 45  ? -14.87105 4.09977   -25.87006 1.000 35.86998 ? 225 GLU A CB   1 
ATOM   538  C CG   . GLU A 1 45  ? -14.00445 4.63367   -27.00396 1.000 36.22983 ? 225 GLU A CG   1 
ATOM   539  C CD   . GLU A 1 45  ? -12.73496 5.29882   -26.51418 1.000 35.62820 ? 225 GLU A CD   1 
ATOM   540  O OE1  . GLU A 1 45  ? -12.50863 5.32191   -25.28691 1.000 40.84146 ? 225 GLU A OE1  1 
ATOM   541  O OE2  . GLU A 1 45  ? -11.96198 5.79717   -27.35934 1.000 35.95220 ? 225 GLU A OE2  1 
ATOM   542  H H    . GLU A 1 45  ? -16.71582 5.20174   -27.02649 1.000 42.13549 ? 225 GLU A H    1 
ATOM   543  H HA   . GLU A 1 45  ? -15.89469 2.71097   -26.96579 1.000 46.25164 ? 225 GLU A HA   1 
ATOM   544  H HB2  . GLU A 1 45  ? -15.10950 4.84710   -25.29949 1.000 40.78373 ? 225 GLU A HB2  1 
ATOM   545  H HB3  . GLU A 1 45  ? -14.34524 3.45560   -25.37059 1.000 40.78373 ? 225 GLU A HB3  1 
ATOM   546  H HG2  . GLU A 1 45  ? -13.75216 3.89666   -27.58194 1.000 41.21555 ? 225 GLU A HG2  1 
ATOM   547  H HG3  . GLU A 1 45  ? -14.51170 5.29049   -27.50614 1.000 41.21555 ? 225 GLU A HG3  1 
ATOM   548  N N    . VAL A 1 46  ? -17.70708 3.58523   -24.48008 1.000 42.58691 ? 226 VAL A N    1 
ATOM   549  C CA   . VAL A 1 46  ? -18.50355 3.04604   -23.38046 1.000 46.73429 ? 226 VAL A CA   1 
ATOM   550  C C    . VAL A 1 46  ? -19.52112 2.03954   -23.90327 1.000 38.19988 ? 226 VAL A C    1 
ATOM   551  O O    . VAL A 1 46  ? -19.73024 0.97495   -23.30741 1.000 38.49399 ? 226 VAL A O    1 
ATOM   552  C CB   . VAL A 1 46  ? -19.18703 4.18864   -22.60667 1.000 35.53401 ? 226 VAL A CB   1 
ATOM   553  C CG1  . VAL A 1 46  ? -20.20660 3.62869   -21.62477 1.000 35.63061 ? 226 VAL A CG1  1 
ATOM   554  C CG2  . VAL A 1 46  ? -18.15056 5.03341   -21.88348 1.000 40.91918 ? 226 VAL A CG2  1 
ATOM   555  H H    . VAL A 1 46  ? -17.80007 4.43055   -24.60810 1.000 51.55634 ? 226 VAL A H    1 
ATOM   556  H HA   . VAL A 1 46  ? -17.90980 2.58167   -22.76994 1.000 56.53320 ? 226 VAL A HA   1 
ATOM   557  H HB   . VAL A 1 46  ? -19.65588 4.75997   -23.23488 1.000 42.27305 ? 226 VAL A HB   1 
ATOM   558  H HG11 . VAL A 1 46  ? -20.41793 4.30914   -20.96658 1.000 40.49648 ? 226 VAL A HG11 1 
ATOM   559  H HG12 . VAL A 1 46  ? -21.00801 3.37794   -22.11034 1.000 40.49648 ? 226 VAL A HG12 1 
ATOM   560  H HG13 . VAL A 1 46  ? -19.82842 2.85048   -21.18629 1.000 40.49648 ? 226 VAL A HG13 1 
ATOM   561  H HG21 . VAL A 1 46  ? -18.58619 5.81425   -21.50743 1.000 49.55507 ? 226 VAL A HG21 1 
ATOM   562  H HG22 . VAL A 1 46  ? -17.75050 4.50471   -21.17543 1.000 49.55507 ? 226 VAL A HG22 1 
ATOM   563  H HG23 . VAL A 1 46  ? -17.46904 5.30775   -22.51685 1.000 49.55507 ? 226 VAL A HG23 1 
ATOM   564  N N    . ARG A 1 47  ? -20.17872 2.36187   -25.01827 1.000 38.98431 ? 227 ARG A N    1 
ATOM   565  C CA   . ARG A 1 47  ? -21.16351 1.44501   -25.57985 1.000 45.29999 ? 227 ARG A CA   1 
ATOM   566  C C    . ARG A 1 47  ? -20.50491 0.19515   -26.14821 1.000 38.86479 ? 227 ARG A C    1 
ATOM   567  O O    . ARG A 1 47  ? -21.12752 -0.86984  -26.17501 1.000 39.55681 ? 227 ARG A O    1 
ATOM   568  C CB   . ARG A 1 47  ? -21.98825 2.15436   -26.65284 1.000 44.56347 ? 227 ARG A CB   1 
ATOM   569  C CG   . ARG A 1 47  ? -23.15768 2.95011   -26.08873 1.000 45.65950 ? 227 ARG A CG   1 
ATOM   570  C CD   . ARG A 1 47  ? -23.92139 3.69136   -27.17529 1.000 50.53036 ? 227 ARG A CD   1 
ATOM   571  N NE   . ARG A 1 47  ? -23.04713 4.52195   -27.99633 1.000 61.95993 ? 227 ARG A NE   1 
ATOM   572  C CZ   . ARG A 1 47  ? -22.89068 5.83226   -27.85312 1.000 63.37589 ? 227 ARG A CZ   1 
ATOM   573  N NH1  . ARG A 1 47  ? -23.53206 6.51072   -26.91439 1.000 47.16516 ? 227 ARG A NH1  1 
ATOM   574  N NH2  . ARG A 1 47  ? -22.06730 6.47932   -28.67297 1.000 56.85571 ? 227 ARG A NH2  1 
ATOM   575  H H    . ARG A 1 47  ? -20.07386 3.09246   -25.45967 1.000 47.23322 ? 227 ARG A H    1 
ATOM   576  H HA   . ARG A 1 47  ? -21.77029 1.16640   -24.87622 1.000 54.81204 ? 227 ARG A HA   1 
ATOM   577  H HB2  . ARG A 1 47  ? -21.41339 2.77025   -27.13358 1.000 53.92821 ? 227 ARG A HB2  1 
ATOM   578  H HB3  . ARG A 1 47  ? -22.34649 1.49036   -27.26248 1.000 53.92821 ? 227 ARG A HB3  1 
ATOM   579  H HG2  . ARG A 1 47  ? -23.77254 2.34393   -25.64670 1.000 55.24345 ? 227 ARG A HG2  1 
ATOM   580  H HG3  . ARG A 1 47  ? -22.82286 3.60358   -25.45487 1.000 55.24345 ? 227 ARG A HG3  1 
ATOM   581  H HD2  . ARG A 1 47  ? -24.35671 3.04658   -27.75465 1.000 61.08848 ? 227 ARG A HD2  1 
ATOM   582  H HD3  . ARG A 1 47  ? -24.58412 4.26685   -26.76235 1.000 61.08848 ? 227 ARG A HD3  1 
ATOM   583  H HE   . ARG A 1 47  ? -22.59969 4.13360   -28.61970 1.000 74.80397 ? 227 ARG A HE   1 
ATOM   584  H HH11 . ARG A 1 47  ? -24.06624 6.10266   -26.37798 1.000 57.05024 ? 227 ARG A HH11 1 
ATOM   585  H HH12 . ARG A 1 47  ? -23.41449 7.35948   -26.84104 1.000 57.05024 ? 227 ARG A HH12 1 
ATOM   586  H HH21 . ARG A 1 47  ? -21.64465 6.04879   -29.28585 1.000 68.67891 ? 227 ARG A HH21 1 
ATOM   587  H HH22 . ARG A 1 47  ? -21.95751 7.32826   -28.59023 1.000 68.67891 ? 227 ARG A HH22 1 
ATOM   588  N N    . ALA A 1 48  ? -19.26053 0.30337   -26.61717 1.000 38.60410 ? 228 ALA A N    1 
ATOM   589  C CA   . ALA A 1 48  ? -18.52170 -0.88622  -27.02711 1.000 39.02362 ? 228 ALA A CA   1 
ATOM   590  C C    . ALA A 1 48  ? -18.21063 -1.77244  -25.82836 1.000 43.04162 ? 228 ALA A C    1 
ATOM   591  O O    . ALA A 1 48  ? -18.30964 -3.00230  -25.91353 1.000 39.25252 ? 228 ALA A O    1 
ATOM   592  C CB   . ALA A 1 48  ? -17.23512 -0.48502  -27.74736 1.000 40.24145 ? 228 ALA A CB   1 
ATOM   593  H H    . ALA A 1 48  ? -18.82950 1.04223   -26.70604 1.000 44.06467 ? 228 ALA A H    1 
ATOM   594  H HA   . ALA A 1 48  ? -19.06413 -1.39521  -27.64967 1.000 46.80357 ? 228 ALA A HA   1 
ATOM   595  H HB1  . ALA A 1 48  ? -16.75844 -1.28708  -28.01263 1.000 48.74179 ? 228 ALA A HB1  1 
ATOM   596  H HB2  . ALA A 1 48  ? -17.46234 0.03923   -28.53122 1.000 48.74179 ? 228 ALA A HB2  1 
ATOM   597  H HB3  . ALA A 1 48  ? -16.68691 0.04154   -27.14478 1.000 48.74179 ? 228 ALA A HB3  1 
ATOM   598  N N    . LEU A 1 49  ? -17.82890 -1.16463  -24.70275 1.000 37.63438 ? 229 LEU A N    1 
ATOM   599  C CA   . LEU A 1 49  ? -17.65326 -1.93896  -23.47767 1.000 37.26388 ? 229 LEU A CA   1 
ATOM   600  C C    . LEU A 1 49  ? -18.95220 -2.63162  -23.08474 1.000 37.88203 ? 229 LEU A C    1 
ATOM   601  O O    . LEU A 1 49  ? -18.95309 -3.81270  -22.71795 1.000 39.41115 ? 229 LEU A O    1 
ATOM   602  C CB   . LEU A 1 49  ? -17.17647 -1.03495  -22.34040 1.000 38.71233 ? 229 LEU A CB   1 
ATOM   603  C CG   . LEU A 1 49  ? -15.77123 -0.44199  -22.44366 1.000 35.54124 ? 229 LEU A CG   1 
ATOM   604  C CD1  . LEU A 1 49  ? -15.60142 0.67649   -21.42818 1.000 34.66163 ? 229 LEU A CD1  1 
ATOM   605  C CD2  . LEU A 1 49  ? -14.71632 -1.51583  -22.23755 1.000 35.48332 ? 229 LEU A CD2  1 
ATOM   606  H H    . LEU A 1 49  ? -17.66894 -0.32325  -24.62472 1.000 42.90102 ? 229 LEU A H    1 
ATOM   607  H HA   . LEU A 1 49  ? -16.97312 -2.61341  -23.63076 1.000 42.45641 ? 229 LEU A HA   1 
ATOM   608  H HB2  . LEU A 1 49  ? -17.79158 -0.28741  -22.27950 1.000 46.90684 ? 229 LEU A HB2  1 
ATOM   609  H HB3  . LEU A 1 49  ? -17.20177 -1.55304  -21.52074 1.000 46.90684 ? 229 LEU A HB3  1 
ATOM   610  H HG   . LEU A 1 49  ? -15.64638 -0.07239  -23.33175 1.000 40.38924 ? 229 LEU A HG   1 
ATOM   611  H HD11 . LEU A 1 49  ? -14.70320 1.03540   -21.50093 1.000 39.33371 ? 229 LEU A HD11 1 
ATOM   612  H HD12 . LEU A 1 49  ? -16.25159 1.37221   -21.61298 1.000 39.33371 ? 229 LEU A HD12 1 
ATOM   613  H HD13 . LEU A 1 49  ? -15.74363 0.31891   -20.53778 1.000 39.33371 ? 229 LEU A HD13 1 
ATOM   614  H HD21 . LEU A 1 49  ? -13.83744 -1.10776  -22.28177 1.000 40.31974 ? 229 LEU A HD21 1 
ATOM   615  H HD22 . LEU A 1 49  ? -14.84773 -1.92482  -21.36786 1.000 40.31974 ? 229 LEU A HD22 1 
ATOM   616  H HD23 . LEU A 1 49  ? -14.80598 -2.18451  -22.93449 1.000 40.31974 ? 229 LEU A HD23 1 
ATOM   617  N N    . HIS A 1 50  ? -20.06946 -1.90546  -23.15434 1.000 38.06446 ? 230 HIS A N    1 
ATOM   618  C CA   . HIS A 1 50  ? -21.36043 -2.48066  -22.78770 1.000 38.73673 ? 230 HIS A CA   1 
ATOM   619  C C    . HIS A 1 50  ? -21.74113 -3.63074  -23.71270 1.000 39.90686 ? 230 HIS A C    1 
ATOM   620  O O    . HIS A 1 50  ? -22.21172 -4.67831  -23.25428 1.000 40.48613 ? 230 HIS A O    1 
ATOM   621  C CB   . HIS A 1 50  ? -22.43834 -1.39617  -22.82157 1.000 38.77607 ? 230 HIS A CB   1 
ATOM   622  C CG   . HIS A 1 50  ? -23.72713 -1.80174  -22.17664 1.000 39.33476 ? 230 HIS A CG   1 
ATOM   623  N ND1  . HIS A 1 50  ? -24.84214 -0.99168  -22.16930 1.000 39.56040 ? 230 HIS A ND1  1 
ATOM   624  C CD2  . HIS A 1 50  ? -24.07886 -2.93107  -21.51767 1.000 39.80021 ? 230 HIS A CD2  1 
ATOM   625  C CE1  . HIS A 1 50  ? -25.82476 -1.60403  -21.53362 1.000 40.14312 ? 230 HIS A CE1  1 
ATOM   626  N NE2  . HIS A 1 50  ? -25.38792 -2.78258  -21.12840 1.000 51.70689 ? 230 HIS A NE2  1 
ATOM   627  H H    . HIS A 1 50  ? -20.10610 -1.08471  -23.40854 1.000 43.41710 ? 230 HIS A H    1 
ATOM   628  H HA   . HIS A 1 50  ? -21.30079 -2.82907  -21.88440 1.000 44.88336 ? 230 HIS A HA   1 
ATOM   629  H HB2  . HIS A 1 50  ? -22.10736 -0.61350  -22.35384 1.000 44.27104 ? 230 HIS A HB2  1 
ATOM   630  H HB3  . HIS A 1 50  ? -22.62786 -1.17435  -23.74666 1.000 44.27104 ? 230 HIS A HB3  1 
ATOM   631  H HD2  . HIS A 1 50  ? -23.53589 -3.66912  -21.35840 1.000 45.50001 ? 230 HIS A HD2  1 
ATOM   632  H HE1  . HIS A 1 50  ? -26.67889 -1.26323  -21.39500 1.000 45.91150 ? 230 HIS A HE1  1 
ATOM   633  H HE2  . HIS A 1 50  ? -25.84829 -3.36300  -20.69164 1.000 62.50032 ? 230 HIS A HE2  1 
ATOM   634  N N    . ASP A 1 51  ? -21.53957 -3.45334  -25.01975 1.000 40.35679 ? 231 ASP A N    1 
ATOM   635  C CA   . ASP A 1 51  ? -21.99043 -4.44005  -25.99422 1.000 41.59757 ? 231 ASP A CA   1 
ATOM   636  C C    . ASP A 1 51  ? -21.25466 -5.76407  -25.84575 1.000 41.93936 ? 231 ASP A C    1 
ATOM   637  O O    . ASP A 1 51  ? -21.81196 -6.81948  -26.16883 1.000 52.61215 ? 231 ASP A O    1 
ATOM   638  C CB   . ASP A 1 51  ? -21.80376 -3.88801  -27.40810 1.000 41.97177 ? 231 ASP A CB   1 
ATOM   639  C CG   . ASP A 1 51  ? -22.40801 -4.78315  -28.46963 1.000 66.79950 ? 231 ASP A CG   1 
ATOM   640  O OD1  . ASP A 1 51  ? -23.64796 -4.93120  -28.48897 1.000 80.24026 ? 231 ASP A OD1  1 
ATOM   641  O OD2  . ASP A 1 51  ? -21.64248 -5.33599  -29.28740 1.000 60.99275 ? 231 ASP A OD2  1 
ATOM   642  H H    . ASP A 1 51  ? -21.14530 -2.77175  -25.36557 1.000 46.16790 ? 231 ASP A H    1 
ATOM   643  H HA   . ASP A 1 51  ? -22.93472 -4.61034  -25.85202 1.000 47.73380 ? 231 ASP A HA   1 
ATOM   644  H HB2  . ASP A 1 51  ? -22.23248 -3.01995  -27.46788 1.000 48.10588 ? 231 ASP A HB2  1 
ATOM   645  H HB3  . ASP A 1 51  ? -20.85511 -3.80285  -27.59171 1.000 48.10588 ? 231 ASP A HB3  1 
ATOM   646  N N    . THR A 1 52  ? -20.01329 -5.73331  -25.36198 1.000 40.07507 ? 232 THR A N    1 
ATOM   647  C CA   . THR A 1 52  ? -19.18397 -6.92456  -25.24965 1.000 44.08776 ? 232 THR A CA   1 
ATOM   648  C C    . THR A 1 52  ? -19.23698 -7.54439  -23.85641 1.000 31.29781 ? 232 THR A C    1 
ATOM   649  O O    . THR A 1 52  ? -18.36011 -8.34067  -23.50475 1.000 31.33735 ? 232 THR A O    1 
ATOM   650  C CB   . THR A 1 52  ? -17.73910 -6.59399  -25.62696 1.000 35.89684 ? 232 THR A CB   1 
ATOM   651  O OG1  . THR A 1 52  ? -17.23977 -5.56243  -24.76707 1.000 39.42040 ? 232 THR A OG1  1 
ATOM   652  C CG2  . THR A 1 52  ? -17.66053 -6.12693  -27.07396 1.000 34.35829 ? 232 THR A CG2  1 
ATOM   653  H H    . THR A 1 52  ? -19.62430 -5.01713  -25.08744 1.000 48.54213 ? 232 THR A H    1 
ATOM   654  H HA   . THR A 1 52  ? -19.51437 -7.58698  -25.87649 1.000 53.35737 ? 232 THR A HA   1 
ATOM   655  H HB   . THR A 1 52  ? -17.18983 -7.38759  -25.52996 1.000 43.52826 ? 232 THR A HB   1 
ATOM   656  H HG1  . THR A 1 52  ? -16.46014 -5.34971  -24.99627 1.000 47.75652 ? 232 THR A HG1  1 
ATOM   657  H HG21 . THR A 1 52  ? -16.73681 -5.96162  -27.31952 1.000 41.68200 ? 232 THR A HG21 1 
ATOM   658  H HG22 . THR A 1 52  ? -18.02589 -6.80623  -27.66214 1.000 41.68200 ? 232 THR A HG22 1 
ATOM   659  H HG23 . THR A 1 52  ? -18.16754 -5.30762  -27.18611 1.000 41.68200 ? 232 THR A HG23 1 
ATOM   660  N N    . GLY A 1 53  ? -20.24036 -7.19259  -23.05885 1.000 33.05194 ? 233 GLY A N    1 
ATOM   661  C CA   . GLY A 1 53  ? -20.42256 -7.82703  -21.76208 1.000 34.83152 ? 233 GLY A CA   1 
ATOM   662  C C    . GLY A 1 53  ? -19.28301 -7.60219  -20.79335 1.000 31.51431 ? 233 GLY A C    1 
ATOM   663  O O    . GLY A 1 53  ? -18.88401 -8.53308  -20.08179 1.000 31.32109 ? 233 GLY A O    1 
ATOM   664  H H    . GLY A 1 53  ? -20.82658 -6.59158  -23.24522 1.000 40.11438 ? 233 GLY A H    1 
ATOM   665  H HA2  . GLY A 1 53  ? -21.23212 -7.48084  -21.35506 1.000 42.24987 ? 233 GLY A HA2  1 
ATOM   666  H HA3  . GLY A 1 53  ? -20.51855 -8.78347  -21.89211 1.000 42.24987 ? 233 GLY A HA3  1 
ATOM   667  N N    . LYS A 1 54  ? -18.74473 -6.38408  -20.74803 1.000 35.34345 ? 234 LYS A N    1 
ATOM   668  C CA   . LYS A 1 54  ? -17.68767 -6.05151  -19.80297 1.000 26.56956 ? 234 LYS A CA   1 
ATOM   669  C C    . LYS A 1 54  ? -18.21559 -5.63622  -18.43678 1.000 30.01788 ? 234 LYS A C    1 
ATOM   670  O O    . LYS A 1 54  ? -17.44045 -5.60250  -17.47426 1.000 27.84194 ? 234 LYS A O    1 
ATOM   671  C CB   . LYS A 1 54  ? -16.81887 -4.91512  -20.35265 1.000 25.49237 ? 234 LYS A CB   1 
ATOM   672  C CG   . LYS A 1 54  ? -16.22398 -5.17493  -21.72471 1.000 36.64360 ? 234 LYS A CG   1 
ATOM   673  C CD   . LYS A 1 54  ? -15.17179 -6.27086  -21.68582 1.000 33.43523 ? 234 LYS A CD   1 
ATOM   674  C CE   . LYS A 1 54  ? -14.32206 -6.25797  -22.94706 1.000 27.75431 ? 234 LYS A CE   1 
ATOM   675  N NZ   . LYS A 1 54  ? -13.88591 -7.62180  -23.35495 1.000 38.07851 ? 234 LYS A NZ   1 
ATOM   676  H H    . LYS A 1 54  ? -18.97779 -5.73196  -21.25794 1.000 42.86419 ? 234 LYS A H    1 
ATOM   677  H HA   . LYS A 1 54  ? -17.12875 -6.83610  -19.68927 1.000 29.62323 ? 234 LYS A HA   1 
ATOM   678  H HB2  . LYS A 1 54  ? -17.36357 -4.11514  -20.41764 1.000 28.33060 ? 234 LYS A HB2  1 
ATOM   679  H HB3  . LYS A 1 54  ? -16.08259 -4.76620  -19.73896 1.000 28.33060 ? 234 LYS A HB3  1 
ATOM   680  H HG2  . LYS A 1 54  ? -16.92814 -5.45164  -22.33174 1.000 44.42437 ? 234 LYS A HG2  1 
ATOM   681  H HG3  . LYS A 1 54  ? -15.80484 -4.36320  -22.05080 1.000 44.42437 ? 234 LYS A HG3  1 
ATOM   682  H HD2  . LYS A 1 54  ? -14.58958 -6.13265  -20.92238 1.000 40.57432 ? 234 LYS A HD2  1 
ATOM   683  H HD3  . LYS A 1 54  ? -15.60767 -7.13479  -21.61853 1.000 40.57432 ? 234 LYS A HD3  1 
ATOM   684  H HE2  . LYS A 1 54  ? -14.83936 -5.87768  -23.67416 1.000 33.75722 ? 234 LYS A HE2  1 
ATOM   685  H HE3  . LYS A 1 54  ? -13.52840 -5.72306  -22.78936 1.000 33.75722 ? 234 LYS A HE3  1 
ATOM   686  H HZ1  . LYS A 1 54  ? -13.40261 -7.99345  -22.70657 1.000 46.14626 ? 234 LYS A HZ1  1 
ATOM   687  H HZ2  . LYS A 1 54  ? -14.59634 -8.13339  -23.51511 1.000 46.14626 ? 234 LYS A HZ2  1 
ATOM   688  H HZ3  . LYS A 1 54  ? -13.39125 -7.57507  -24.09335 1.000 46.14626 ? 234 LYS A HZ3  1 
ATOM   689  N N    . PHE A 1 55  ? -19.50354 -5.32431  -18.32669 1.000 28.62369 ? 235 PHE A N    1 
ATOM   690  C CA   . PHE A 1 55  ? -20.05671 -4.75414  -17.10774 1.000 25.46839 ? 235 PHE A CA   1 
ATOM   691  C C    . PHE A 1 55  ? -20.53345 -5.85234  -16.16624 1.000 26.33458 ? 235 PHE A C    1 
ATOM   692  O O    . PHE A 1 55  ? -21.10157 -6.85821  -16.60005 1.000 29.87376 ? 235 PHE A O    1 
ATOM   693  C CB   . PHE A 1 55  ? -21.21970 -3.81412  -17.43322 1.000 29.44643 ? 235 PHE A CB   1 
ATOM   694  C CG   . PHE A 1 55  ? -20.83272 -2.61646  -18.26094 1.000 29.59423 ? 235 PHE A CG   1 
ATOM   695  C CD1  . PHE A 1 55  ? -19.50989 -2.21936  -18.37504 1.000 32.43305 ? 235 PHE A CD1  1 
ATOM   696  C CD2  . PHE A 1 55  ? -21.80347 -1.88342  -18.92210 1.000 31.05329 ? 235 PHE A CD2  1 
ATOM   697  C CE1  . PHE A 1 55  ? -19.16624 -1.11850  -19.13514 1.000 26.97111 ? 235 PHE A CE1  1 
ATOM   698  C CE2  . PHE A 1 55  ? -21.46462 -0.78290  -19.68168 1.000 35.25207 ? 235 PHE A CE2  1 
ATOM   699  C CZ   . PHE A 1 55  ? -20.14437 -0.40025  -19.78821 1.000 24.25446 ? 235 PHE A CZ   1 
ATOM   700  H H    . PHE A 1 55  ? -20.08247 -5.43564  -18.95282 1.000 34.80047 ? 235 PHE A H    1 
ATOM   701  H HA   . PHE A 1 55  ? -19.36519 -4.24655  -16.65491 1.000 28.30182 ? 235 PHE A HA   1 
ATOM   702  H HB2  . PHE A 1 55  ? -21.88997 -4.31007  -17.92888 1.000 35.78776 ? 235 PHE A HB2  1 
ATOM   703  H HB3  . PHE A 1 55  ? -21.59656 -3.48737  -16.60129 1.000 35.78776 ? 235 PHE A HB3  1 
ATOM   704  H HD1  . PHE A 1 55  ? -18.84610 -2.69952  -17.93488 1.000 39.37171 ? 235 PHE A HD1  1 
ATOM   705  H HD2  . PHE A 1 55  ? -22.69577 -2.13631  -18.85322 1.000 37.71600 ? 235 PHE A HD2  1 
ATOM   706  H HE1  . PHE A 1 55  ? -18.27512 -0.86207  -19.20617 1.000 32.81738 ? 235 PHE A HE1  1 
ATOM   707  H HE2  . PHE A 1 55  ? -22.12621 -0.29946  -20.12156 1.000 42.75453 ? 235 PHE A HE2  1 
ATOM   708  H HZ   . PHE A 1 55  ? -19.91425 0.34139   -20.29998 1.000 29.55740 ? 235 PHE A HZ   1 
ATOM   709  N N    . THR A 1 56  ? -20.29693 -5.64783  -14.87200 1.000 33.07116 ? 236 THR A N    1 
ATOM   710  C CA   . THR A 1 56  ? -20.74722 -6.55058  -13.82323 1.000 28.79458 ? 236 THR A CA   1 
ATOM   711  C C    . THR A 1 56  ? -21.41969 -5.73619  -12.72535 1.000 25.80870 ? 236 THR A C    1 
ATOM   712  O O    . THR A 1 56  ? -21.31216 -4.50795  -12.67755 1.000 31.02875 ? 236 THR A O    1 
ATOM   713  C CB   . THR A 1 56  ? -19.58595 -7.37155  -13.24443 1.000 26.25938 ? 236 THR A CB   1 
ATOM   714  O OG1  . THR A 1 56  ? -18.58233 -6.49176  -12.72351 1.000 25.35554 ? 236 THR A OG1  1 
ATOM   715  C CG2  . THR A 1 56  ? -18.97383 -8.25937  -14.31840 1.000 30.29978 ? 236 THR A CG2  1 
ATOM   716  H H    . THR A 1 56  ? -19.86291 -4.96960  -14.56994 1.000 40.13745 ? 236 THR A H    1 
ATOM   717  H HA   . THR A 1 56  ? -21.39631 -7.17119  -14.18988 1.000 35.00554 ? 236 THR A HA   1 
ATOM   718  H HB   . THR A 1 56  ? -19.91641 -7.93833  -12.52998 1.000 30.29149 ? 236 THR A HB   1 
ATOM   719  H HG1  . THR A 1 56  ? -18.28698 -5.99830  -13.33577 1.000 30.87869 ? 236 THR A HG1  1 
ATOM   720  H HG21 . THR A 1 56  ? -18.17678 -8.69313  -13.97568 1.000 36.81178 ? 236 THR A HG21 1 
ATOM   721  H HG22 . THR A 1 56  ? -19.61043 -8.93926  -14.58933 1.000 36.81178 ? 236 THR A HG22 1 
ATOM   722  H HG23 . THR A 1 56  ? -18.73400 -7.72633  -15.09251 1.000 36.81178 ? 236 THR A HG23 1 
ATOM   723  N N    . ASP A 1 57  ? -22.11390 -6.43842  -11.83182 1.000 26.77611 ? 237 ASP A N    1 
ATOM   724  C CA   . ASP A 1 57  ? -22.90229 -5.77446  -10.80111 1.000 27.25921 ? 237 ASP A CA   1 
ATOM   725  C C    . ASP A 1 57  ? -22.03383 -4.84121  -9.96670  1.000 25.33335 ? 237 ASP A C    1 
ATOM   726  O O    . ASP A 1 57  ? -20.97652 -5.23585  -9.46604  1.000 24.57697 ? 237 ASP A O    1 
ATOM   727  C CB   . ASP A 1 57  ? -23.56452 -6.81493  -9.89653  1.000 35.20904 ? 237 ASP A CB   1 
ATOM   728  C CG   . ASP A 1 57  ? -24.70777 -7.54035  -10.57726 1.000 33.83408 ? 237 ASP A CG   1 
ATOM   729  O OD1  . ASP A 1 57  ? -25.15040 -7.08378  -11.65234 1.000 40.40910 ? 237 ASP A OD1  1 
ATOM   730  O OD2  . ASP A 1 57  ? -25.16514 -8.56804  -10.03370 1.000 31.11026 ? 237 ASP A OD2  1 
ATOM   731  H H    . ASP A 1 57  ? -22.14420 -7.29736  -11.80188 1.000 31.32385 ? 237 ASP A H    1 
ATOM   732  H HA   . ASP A 1 57  ? -23.59423 -5.24521  -11.22775 1.000 33.16310 ? 237 ASP A HA   1 
ATOM   733  H HB2  . ASP A 1 57  ? -22.90284 -7.47488  -9.63664  1.000 42.70290 ? 237 ASP A HB2  1 
ATOM   734  H HB3  . ASP A 1 57  ? -23.91718 -6.37097  -9.10949  1.000 42.70290 ? 237 ASP A HB3  1 
ATOM   735  N N    . GLY A 1 58  ? -22.49027 -3.59975  -9.81348  1.000 29.35802 ? 238 GLY A N    1 
ATOM   736  C CA   . GLY A 1 58  ? -21.82293 -2.64880  -8.94689  1.000 32.35341 ? 238 GLY A CA   1 
ATOM   737  C C    . GLY A 1 58  ? -21.76663 -3.14535  -7.51821  1.000 29.53592 ? 238 GLY A C    1 
ATOM   738  O O    . GLY A 1 58  ? -22.77223 -3.62361  -6.98478  1.000 29.01723 ? 238 GLY A O    1 
ATOM   739  H H    . GLY A 1 58  ? -23.18919 -3.28719  -10.20516 1.000 35.68168 ? 238 GLY A H    1 
ATOM   740  H HA2  . GLY A 1 58  ? -20.91645 -2.50465  -9.26062  1.000 39.27614 ? 238 GLY A HA2  1 
ATOM   741  H HA3  . GLY A 1 58  ? -22.30059 -1.80471  -8.96281  1.000 39.27614 ? 238 GLY A HA3  1 
ATOM   742  N N    . GLN A 1 59  ? -20.60317 -3.03867  -6.88702  1.000 30.19197 ? 239 GLN A N    1 
ATOM   743  C CA   . GLN A 1 59  ? -20.37339 -3.60195  -5.56562  1.000 34.46616 ? 239 GLN A CA   1 
ATOM   744  C C    . GLN A 1 59  ? -20.30868 -2.50112  -4.51476  1.000 28.33191 ? 239 GLN A C    1 
ATOM   745  O O    . GLN A 1 59  ? -20.27112 -1.30652  -4.82284  1.000 24.83139 ? 239 GLN A O    1 
ATOM   746  C CB   . GLN A 1 59  ? -19.08355 -4.42997  -5.55249  1.000 23.74132 ? 239 GLN A CB   1 
ATOM   747  C CG   . GLN A 1 59  ? -19.14154 -5.65656  -6.44279  1.000 24.24554 ? 239 GLN A CG   1 
ATOM   748  C CD   . GLN A 1 59  ? -20.20334 -6.63803  -5.99816  1.000 25.88326 ? 239 GLN A CD   1 
ATOM   749  O OE1  . GLN A 1 59  ? -20.11658 -7.21171  -4.91339  1.000 26.03755 ? 239 GLN A OE1  1 
ATOM   750  N NE2  . GLN A 1 59  ? -21.22032 -6.82917  -6.83085  1.000 28.45496 ? 239 GLN A NE2  1 
ATOM   751  H H    . GLN A 1 59  ? -19.91736 -2.63494  -7.21300  1.000 36.68241 ? 239 GLN A H    1 
ATOM   752  H HA   . GLN A 1 59  ? -21.11536 -4.18377  -5.33788  1.000 41.81145 ? 239 GLN A HA   1 
ATOM   753  H HB2  . GLN A 1 59  ? -18.35161 -3.87329  -5.86114  1.000 28.94164 ? 239 GLN A HB2  1 
ATOM   754  H HB3  . GLN A 1 59  ? -18.91333 -4.72903  -4.64558  1.000 28.94164 ? 239 GLN A HB3  1 
ATOM   755  H HG2  . GLN A 1 59  ? -19.34565 -5.38140  -7.35028  1.000 29.54670 ? 239 GLN A HG2  1 
ATOM   756  H HG3  . GLN A 1 59  ? -18.28347 -6.10821  -6.41812  1.000 29.54670 ? 239 GLN A HG3  1 
ATOM   757  H HE21 . GLN A 1 59  ? -21.24991 -6.40449  -7.57809  1.000 34.59800 ? 239 GLN A HE21 1 
ATOM   758  H HE22 . GLN A 1 59  ? -21.84922 -7.37761  -6.62275  1.000 34.59800 ? 239 GLN A HE22 1 
ATOM   759  N N    . LEU A 1 60  ? -20.29523 -2.93080  -3.25494  1.000 28.33129 ? 240 LEU A N    1 
ATOM   760  C CA   . LEU A 1 60  ? -20.26711 -2.04157  -2.10551  1.000 24.04247 ? 240 LEU A CA   1 
ATOM   761  C C    . LEU A 1 60  ? -18.99917 -2.28478  -1.29775  1.000 26.73962 ? 240 LEU A C    1 
ATOM   762  O O    . LEU A 1 60  ? -18.38520 -3.35299  -1.37025  1.000 30.61418 ? 240 LEU A O    1 
ATOM   763  C CB   . LEU A 1 60  ? -21.49768 -2.24796  -1.20914  1.000 26.04622 ? 240 LEU A CB   1 
ATOM   764  C CG   . LEU A 1 60  ? -22.86808 -1.83890  -1.75982  1.000 29.54211 ? 240 LEU A CG   1 
ATOM   765  C CD1  . LEU A 1 60  ? -22.81207 -0.47806  -2.44015  1.000 28.83622 ? 240 LEU A CD1  1 
ATOM   766  C CD2  . LEU A 1 60  ? -23.41089 -2.89571  -2.71568  1.000 24.96889 ? 240 LEU A CD2  1 
ATOM   767  H H    . LEU A 1 60  ? -20.30226 -3.76273  -3.03712  1.000 34.44960 ? 240 LEU A H    1 
ATOM   768  H HA   . LEU A 1 60  ? -20.26516 -1.12126  -2.41199  1.000 29.30301 ? 240 LEU A HA   1 
ATOM   769  H HB2  . LEU A 1 60  ? -21.55326 -3.19327  -0.99891  1.000 31.70752 ? 240 LEU A HB2  1 
ATOM   770  H HB3  . LEU A 1 60  ? -21.35970 -1.73513  -0.39744  1.000 31.70752 ? 240 LEU A HB3  1 
ATOM   771  H HG   . LEU A 1 60  ? -23.48227 -1.76649  -1.01253  1.000 35.90258 ? 240 LEU A HG   1 
ATOM   772  H HD11 . LEU A 1 60  ? -23.71585 -0.18601  -2.63708  1.000 35.05552 ? 240 LEU A HD11 1 
ATOM   773  H HD12 . LEU A 1 60  ? -22.38218 0.15536   -1.84444  1.000 35.05552 ? 240 LEU A HD12 1 
ATOM   774  H HD13 . LEU A 1 60  ? -22.30333 -0.55671  -3.26227  1.000 35.05552 ? 240 LEU A HD13 1 
ATOM   775  H HD21 . LEU A 1 60  ? -24.32656 -2.67309  -2.94562  1.000 28.78059 ? 240 LEU A HD21 1 
ATOM   776  H HD22 . LEU A 1 60  ? -23.38054 -3.76154  -2.27943  1.000 28.78059 ? 240 LEU A HD22 1 
ATOM   777  H HD23 . LEU A 1 60  ? -22.86280 -2.90912  -3.51588  1.000 28.78059 ? 240 LEU A HD23 1 
ATOM   778  N N    . VAL A 1 61  ? -18.61231 -1.27228  -0.51924  1.000 24.65307 ? 241 VAL A N    1 
ATOM   779  C CA   . VAL A 1 61  ? -17.41462 -1.38662  0.30975   1.000 22.78469 ? 241 VAL A CA   1 
ATOM   780  C C    . VAL A 1 61  ? -17.55733 -2.54558  1.28865   1.000 28.94991 ? 241 VAL A C    1 
ATOM   781  O O    . VAL A 1 61  ? -16.64578 -3.36722  1.44524   1.000 27.80545 ? 241 VAL A O    1 
ATOM   782  C CB   . VAL A 1 61  ? -17.14546 -0.06143  1.04615   1.000 34.27719 ? 241 VAL A CB   1 
ATOM   783  C CG1  . VAL A 1 61  ? -16.08598 -0.25347  2.12374   1.000 27.31361 ? 241 VAL A CG1  1 
ATOM   784  C CG2  . VAL A 1 61  ? -16.72530 1.01823   0.06173   1.000 34.35957 ? 241 VAL A CG2  1 
ATOM   785  H H    . VAL A 1 61  ? -19.02102 -0.51840  -0.45424  1.000 30.03574 ? 241 VAL A H    1 
ATOM   786  H HA   . VAL A 1 61  ? -16.65700 -1.57180  -0.26697  1.000 27.79367 ? 241 VAL A HA   1 
ATOM   787  H HB   . VAL A 1 61  ? -17.96333 0.22881   1.47946   1.000 41.58468 ? 241 VAL A HB   1 
ATOM   788  H HG11 . VAL A 1 61  ? -15.73075 0.61335   2.37540   1.000 33.22839 ? 241 VAL A HG11 1 
ATOM   789  H HG12 . VAL A 1 61  ? -16.49264 -0.68056  2.89388   1.000 33.22839 ? 241 VAL A HG12 1 
ATOM   790  H HG13 . VAL A 1 61  ? -15.37563 -0.81263  1.77211   1.000 33.22839 ? 241 VAL A HG13 1 
ATOM   791  H HG21 . VAL A 1 61  ? -16.56746 1.84347   0.54647   1.000 41.68354 ? 241 VAL A HG21 1 
ATOM   792  H HG22 . VAL A 1 61  ? -15.91240 0.73749   -0.38692  1.000 41.68354 ? 241 VAL A HG22 1 
ATOM   793  H HG23 . VAL A 1 61  ? -17.43419 1.14654   -0.58781  1.000 41.68354 ? 241 VAL A HG23 1 
ATOM   794  N N    . SER A 1 62  ? -18.70397 -2.62803  1.96103   1.000 31.27229 ? 242 SER A N    1 
ATOM   795  C CA   A SER A 1 62  ? -18.97934 -3.67081  2.94468   0.440 31.95361 ? 242 SER A CA   1 
ATOM   796  C CA   B SER A 1 62  ? -18.97934 -3.67082  2.94464   0.560 31.93453 ? 242 SER A CA   1 
ATOM   797  C C    . SER A 1 62  ? -20.18655 -4.46957  2.47145   1.000 37.88435 ? 242 SER A C    1 
ATOM   798  O O    . SER A 1 62  ? -21.30093 -3.93941  2.40654   1.000 31.45817 ? 242 SER A O    1 
ATOM   799  C CB   A SER A 1 62  ? -19.22849 -3.06649  4.32623   0.440 35.74579 ? 242 SER A CB   1 
ATOM   800  C CB   B SER A 1 62  ? -19.22850 -3.06651  4.32617   0.560 35.74531 ? 242 SER A CB   1 
ATOM   801  O OG   A SER A 1 62  ? -19.55631 -4.07007  5.27115   0.440 45.55923 ? 242 SER A OG   1 
ATOM   802  O OG   B SER A 1 62  ? -19.58245 -4.06687  5.26499   0.560 45.62208 ? 242 SER A OG   1 
ATOM   803  H H    A SER A 1 62  ? -19.35502 -2.07514  1.86081   0.440 37.97879 ? 242 SER A H    1 
ATOM   804  H H    B SER A 1 62  ? -19.35501 -2.07513  1.86082   0.560 37.97879 ? 242 SER A H    1 
ATOM   805  H HA   . SER A 1 62  ? -18.21843 -4.26958  3.00297   1.000 38.77349 ? 242 SER A HA   1 
ATOM   806  H HB2  A SER A 1 62  ? -18.42483 -2.60906  4.61913   0.440 43.34699 ? 242 SER A HB2  1 
ATOM   807  H HB2  B SER A 1 62  ? -18.41893 -2.62499  4.62708   0.560 43.34643 ? 242 SER A HB2  1 
ATOM   808  H HB3  A SER A 1 62  ? -19.96491 -2.43797  4.26655   0.440 43.34699 ? 242 SER A HB3  1 
ATOM   809  H HB3  B SER A 1 62  ? -19.95266 -2.42429  4.26268   0.560 43.34643 ? 242 SER A HB3  1 
ATOM   810  H HG   A SER A 1 62  ? -18.92486 -4.62013  5.33679   0.440 55.12312 ? 242 SER A HG   1 
ATOM   811  H HG   B SER A 1 62  ? -18.96182 -4.62871  5.33388   0.560 55.19855 ? 242 SER A HG   1 
ATOM   812  N N    . GLN A 1 63  ? -19.96681 -5.73994  2.14363   1.000 35.10077 ? 243 GLN A N    1 
ATOM   813  C CA   . GLN A 1 63  ? -21.04294 -6.61601  1.70580   1.000 36.05117 ? 243 GLN A CA   1 
ATOM   814  C C    . GLN A 1 63  ? -21.59148 -7.39591  2.89296   1.000 43.15766 ? 243 GLN A C    1 
ATOM   815  O O    . GLN A 1 63  ? -20.83463 -7.91871  3.71647   1.000 30.22787 ? 243 GLN A O    1 
ATOM   816  C CB   . GLN A 1 63  ? -20.55869 -7.57871  0.61883   1.000 32.51136 ? 243 GLN A CB   1 
ATOM   817  C CG   . GLN A 1 63  ? -21.61497 -8.58255  0.16312   1.000 33.89047 ? 243 GLN A CG   1 
ATOM   818  C CD   . GLN A 1 63  ? -22.68205 -7.95208  -0.71184  1.000 39.45741 ? 243 GLN A CD   1 
ATOM   819  O OE1  . GLN A 1 63  ? -22.64660 -6.75346  -0.98752  1.000 32.90730 ? 243 GLN A OE1  1 
ATOM   820  N NE2  . GLN A 1 63  ? -23.64896 -8.75594  -1.13824  1.000 42.71836 ? 243 GLN A NE2  1 
ATOM   821  H H    . GLN A 1 63  ? -19.19527 -6.11910  2.16756   1.000 42.57297 ? 243 GLN A H    1 
ATOM   822  H HA   . GLN A 1 63  ? -21.76036 -6.08307  1.32874   1.000 43.71346 ? 243 GLN A HA   1 
ATOM   823  H HB2  . GLN A 1 63  ? -20.28877 -7.06191  -0.15639  1.000 39.46568 ? 243 GLN A HB2  1 
ATOM   824  H HB3  . GLN A 1 63  ? -19.80314 -8.08076  0.96232   1.000 39.46568 ? 243 GLN A HB3  1 
ATOM   825  H HG2  . GLN A 1 63  ? -21.18396 -9.28521  -0.34817  1.000 41.12061 ? 243 GLN A HG2  1 
ATOM   826  H HG3  . GLN A 1 63  ? -22.05065 -8.95961  0.94344   1.000 41.12061 ? 243 GLN A HG3  1 
ATOM   827  H HE21 . GLN A 1 63  ? -23.64701 -9.58662  -0.91561  1.000 51.71409 ? 243 GLN A HE21 1 
ATOM   828  H HE22 . GLN A 1 63  ? -24.27720 -8.44593  -1.63706  1.000 51.71409 ? 243 GLN A HE22 1 
ATOM   829  N N    . LYS A 1 64  ? -22.91425 -7.47363  2.96707   1.000 31.62275 ? 244 LYS A N    1 
ATOM   830  C CA   . LYS A 1 64  ? -23.59974 -8.13478  4.06980   1.000 42.29419 ? 244 LYS A CA   1 
ATOM   831  C C    . LYS A 1 64  ? -24.77189 -8.91065  3.47690   1.000 41.53392 ? 244 LYS A C    1 
ATOM   832  O O    . LYS A 1 64  ? -24.83262 -9.15700  2.26724   1.000 40.52389 ? 244 LYS A O    1 
ATOM   833  C CB   . LYS A 1 64  ? -24.00940 -7.10602  5.13528   1.000 47.07992 ? 244 LYS A CB   1 
ATOM   834  C CG   . LYS A 1 64  ? -22.82843 -6.47970  5.86393   1.000 46.67544 ? 244 LYS A CG   1 
ATOM   835  C CD   . LYS A 1 64  ? -23.28453 -5.60742  7.02197   1.000 45.35723 ? 244 LYS A CD   1 
ATOM   836  H H    . LYS A 1 64  ? -23.44802 -7.14428  2.37866   1.000 38.39935 ? 244 LYS A H    1 
ATOM   837  H HA   . LYS A 1 64  ? -22.99576 -8.77058  4.48436   1.000 51.20508 ? 244 LYS A HA   1 
ATOM   838  H HB2  . LYS A 1 64  ? -24.50556 -6.39187  4.70549   1.000 56.94795 ? 244 LYS A HB2  1 
ATOM   839  H HB3  . LYS A 1 64  ? -24.56656 -7.54591  5.79631   1.000 56.94795 ? 244 LYS A HB3  1 
ATOM   840  H HG2  . LYS A 1 64  ? -22.26015 -7.18198  6.21714   1.000 56.46258 ? 244 LYS A HG2  1 
ATOM   841  H HG3  . LYS A 1 64  ? -22.32641 -5.92639  5.24528   1.000 56.46258 ? 244 LYS A HG3  1 
ATOM   842  N N    . SER A 1 65  ? -25.71442 -9.31175  4.33322   1.000 42.38653 ? 245 SER A N    1 
ATOM   843  C CA   . SER A 1 65  ? -26.79941 -10.18851 3.90624   1.000 46.06074 ? 245 SER A CA   1 
ATOM   844  C C    . SER A 1 65  ? -27.55678 -9.65766  2.69502   1.000 37.54873 ? 245 SER A C    1 
ATOM   845  O O    . SER A 1 65  ? -28.19585 -10.44266 1.98530   1.000 41.62995 ? 245 SER A O    1 
ATOM   846  C CB   . SER A 1 65  ? -27.77800 -10.39994 5.06497   1.000 48.09998 ? 245 SER A CB   1 
ATOM   847  O OG   . SER A 1 65  ? -28.55014 -9.23429  5.29847   1.000 44.71591 ? 245 SER A OG   1 
ATOM   848  H H    . SER A 1 65  ? -25.74643 -9.08999  5.16352   1.000 51.31589 ? 245 SER A H    1 
ATOM   849  H HA   . SER A 1 65  ? -26.41603 -11.04441 3.65854   1.000 55.72494 ? 245 SER A HA   1 
ATOM   850  H HB2  . SER A 1 65  ? -28.37348 -11.13321 4.84447   1.000 58.17203 ? 245 SER A HB2  1 
ATOM   851  H HB3  . SER A 1 65  ? -27.27525 -10.61061 5.86731   1.000 58.17203 ? 245 SER A HB3  1 
ATOM   852  H HG   . SER A 1 65  ? -29.07619 -9.36203  5.94077   1.000 54.11114 ? 245 SER A HG   1 
ATOM   853  N N    . ASP A 1 66  ? -27.50286 -8.35489  2.43758   1.000 45.07811 ? 246 ASP A N    1 
ATOM   854  C CA   . ASP A 1 66  ? -28.29034 -7.76463  1.36617   1.000 35.59274 ? 246 ASP A CA   1 
ATOM   855  C C    . ASP A 1 66  ? -27.61511 -7.94679  0.01218   1.000 34.49009 ? 246 ASP A C    1 
ATOM   856  O O    . ASP A 1 66  ? -26.38638 -7.97825  -0.09888  1.000 33.24390 ? 246 ASP A O    1 
ATOM   857  C CB   . ASP A 1 66  ? -28.51449 -6.27613  1.62961   1.000 34.45320 ? 246 ASP A CB   1 
ATOM   858  C CG   . ASP A 1 66  ? -29.62959 -6.02472  2.61876   1.000 35.94188 ? 246 ASP A CG   1 
ATOM   859  O OD1  . ASP A 1 66  ? -30.75840 -6.49571  2.37085   1.000 46.31015 ? 246 ASP A OD1  1 
ATOM   860  O OD2  . ASP A 1 66  ? -29.37524 -5.36500  3.64788   1.000 44.14608 ? 246 ASP A OD2  1 
ATOM   861  H H    . ASP A 1 66  ? -27.01714 -7.79231  2.87021   1.000 54.54579 ? 246 ASP A H    1 
ATOM   862  H HA   . ASP A 1 66  ? -29.15207 -8.20846  1.32973   1.000 40.45104 ? 246 ASP A HA   1 
ATOM   863  H HB2  . ASP A 1 66  ? -27.70009 -5.89184  1.99012   1.000 39.08360 ? 246 ASP A HB2  1 
ATOM   864  H HB3  . ASP A 1 66  ? -28.74726 -5.83820  0.79598   1.000 39.08360 ? 246 ASP A HB3  1 
ATOM   865  N N    . SER A 1 67  ? -28.44145 -8.06727  -1.02396  1.000 35.09594 ? 247 SER A N    1 
ATOM   866  C CA   . SER A 1 67  ? -27.95156 -8.10472  -2.39387  1.000 39.86653 ? 247 SER A CA   1 
ATOM   867  C C    . SER A 1 67  ? -27.53489 -6.70908  -2.83871  1.000 38.36540 ? 247 SER A C    1 
ATOM   868  O O    . SER A 1 67  ? -28.16067 -5.71027  -2.47074  1.000 32.02087 ? 247 SER A O    1 
ATOM   869  C CB   . SER A 1 67  ? -29.02638 -8.65277  -3.33321  1.000 37.96018 ? 247 SER A CB   1 
ATOM   870  O OG   . SER A 1 67  ? -28.68747 -8.41337  -4.68851  1.000 45.44744 ? 247 SER A OG   1 
ATOM   871  H H    . SER A 1 67  ? -29.29661 -8.12945  -0.95733  1.000 39.85489 ? 247 SER A H    1 
ATOM   872  H HA   . SER A 1 67  ? -27.17994 -8.69011  -2.44706  1.000 48.29189 ? 247 SER A HA   1 
ATOM   873  H HB2  . SER A 1 67  ? -29.10914 -9.60906  -3.19336  1.000 46.00427 ? 247 SER A HB2  1 
ATOM   874  H HB3  . SER A 1 67  ? -29.86929 -8.21464  -3.13714  1.000 46.00427 ? 247 SER A HB3  1 
ATOM   875  H HG   . SER A 1 67  ? -29.28363 -8.72308  -5.19275  1.000 54.98897 ? 247 SER A HG   1 
ATOM   876  N N    . SER A 1 68  ? -26.47018 -6.64626  -3.64128  1.000 34.77003 ? 248 SER A N    1 
ATOM   877  C CA   . SER A 1 68  ? -25.96782 -5.35513  -4.09734  1.000 41.80762 ? 248 SER A CA   1 
ATOM   878  C C    . SER A 1 68  ? -27.00013 -4.61254  -4.93530  1.000 37.09132 ? 248 SER A C    1 
ATOM   879  O O    . SER A 1 68  ? -26.98746 -3.37695  -4.98192  1.000 33.89827 ? 248 SER A O    1 
ATOM   880  C CB   . SER A 1 68  ? -24.68046 -5.54888  -4.89870  1.000 35.43938 ? 248 SER A CB   1 
ATOM   881  O OG   . SER A 1 68  ? -24.89768 -6.39647  -6.01372  1.000 28.81016 ? 248 SER A OG   1 
ATOM   882  H H    . SER A 1 68  ? -26.02941 -7.32584  -3.93024  1.000 42.17609 ? 248 SER A H    1 
ATOM   883  H HA   . SER A 1 68  ? -25.76382 -4.81019  -3.32125  1.000 50.62119 ? 248 SER A HA   1 
ATOM   884  H HB2  . SER A 1 68  ? -24.37331 -4.68486  -5.21499  1.000 42.97931 ? 248 SER A HB2  1 
ATOM   885  H HB3  . SER A 1 68  ? -24.00930 -5.94969  -4.32442  1.000 42.97931 ? 248 SER A HB3  1 
ATOM   886  H HG   . SER A 1 68  ? -24.18341 -6.49221  -6.44529  1.000 33.86650 ? 248 SER A HG   1 
ATOM   887  N N    . LYS A 1 69  ? -27.89987 -5.33926  -5.60194  1.000 30.78070 ? 249 LYS A N    1 
ATOM   888  C CA   . LYS A 1 69  ? -28.87804 -4.68928  -6.46605  1.000 38.87253 ? 249 LYS A CA   1 
ATOM   889  C C    . LYS A 1 69  ? -29.97055 -3.97977  -5.67645  1.000 31.87032 ? 249 LYS A C    1 
ATOM   890  O O    . LYS A 1 69  ? -30.68241 -3.14450  -6.24410  1.000 31.97040 ? 249 LYS A O    1 
ATOM   891  C CB   . LYS A 1 69  ? -29.49581 -5.71208  -7.41924  1.000 35.83257 ? 249 LYS A CB   1 
ATOM   892  C CG   . LYS A 1 69  ? -28.53883 -6.18748  -8.50245  1.000 37.56390 ? 249 LYS A CG   1 
ATOM   893  C CD   . LYS A 1 69  ? -29.18107 -7.23326  -9.39886  1.000 51.87956 ? 249 LYS A CD   1 
ATOM   894  C CE   . LYS A 1 69  ? -28.23727 -7.66761  -10.50938 1.000 39.85267 ? 249 LYS A CE   1 
ATOM   895  H H    . LYS A 1 69  ? -27.96196 -6.19642  -5.56986  1.000 34.67660 ? 249 LYS A H    1 
ATOM   896  H HA   . LYS A 1 69  ? -28.42362 -4.02062  -7.00204  1.000 47.09909 ? 249 LYS A HA   1 
ATOM   897  H HB2  . LYS A 1 69  ? -29.77475 -6.48766  -6.90780  1.000 43.45114 ? 249 LYS A HB2  1 
ATOM   898  H HB3  . LYS A 1 69  ? -30.26262 -5.30936  -7.85595  1.000 43.45114 ? 249 LYS A HB3  1 
ATOM   899  H HG2  . LYS A 1 69  ? -28.27810 -5.43310  -9.05366  1.000 45.52873 ? 249 LYS A HG2  1 
ATOM   900  H HG3  . LYS A 1 69  ? -27.75557 -6.58184  -8.08786  1.000 45.52873 ? 249 LYS A HG3  1 
ATOM   901  H HD2  . LYS A 1 69  ? -29.40974 -8.01359  -8.87000  1.000 62.70752 ? 249 LYS A HD2  1 
ATOM   902  H HD3  . LYS A 1 69  ? -29.97991 -6.86201  -9.80498  1.000 62.70752 ? 249 LYS A HD3  1 
ATOM   903  N N    . ASP A 1 70  ? -30.12448 -4.29146  -4.38928  1.000 36.51341 ? 250 ASP A N    1 
ATOM   904  C CA   . ASP A 1 70  ? -31.02203 -3.52830  -3.53248  1.000 35.76339 ? 250 ASP A CA   1 
ATOM   905  C C    . ASP A 1 70  ? -30.44300 -2.17571  -3.13972  1.000 31.45546 ? 250 ASP A C    1 
ATOM   906  O O    . ASP A 1 70  ? -31.17467 -1.33939  -2.59811  1.000 31.85765 ? 250 ASP A O    1 
ATOM   907  C CB   . ASP A 1 70  ? -31.35049 -4.32460  -2.26707  1.000 34.61850 ? 250 ASP A CB   1 
ATOM   908  C CG   . ASP A 1 70  ? -32.11654 -5.59915  -2.56142  1.000 49.18559 ? 250 ASP A CG   1 
ATOM   909  O OD1  . ASP A 1 70  ? -33.24099 -5.50772  -3.09690  1.000 49.80046 ? 250 ASP A OD1  1 
ATOM   910  O OD2  . ASP A 1 70  ? -31.59702 -6.69206  -2.25218  1.000 51.26493 ? 250 ASP A OD2  1 
ATOM   911  H H    . ASP A 1 70  ? -29.72047 -4.93870  -3.99248  1.000 44.26814 ? 250 ASP A H    1 
ATOM   912  H HA   . ASP A 1 70  ? -31.85236 -3.37637  -4.01036  1.000 43.36811 ? 250 ASP A HA   1 
ATOM   913  H HB2  . ASP A 1 70  ? -30.52336 -4.56725  -1.82224  1.000 41.99424 ? 250 ASP A HB2  1 
ATOM   914  H HB3  . ASP A 1 70  ? -31.89425 -3.77610  -1.68023  1.000 41.99424 ? 250 ASP A HB3  1 
ATOM   915  N N    . ILE A 1 71  ? -29.15946 -1.94492  -3.40011  1.000 29.74403 ? 251 ILE A N    1 
ATOM   916  C CA   . ILE A 1 71  ? -28.47696 -0.71248  -3.02898  1.000 33.12647 ? 251 ILE A CA   1 
ATOM   917  C C    . ILE A 1 71  ? -28.11588 0.11103   -4.26064  1.000 36.98307 ? 251 ILE A C    1 
ATOM   918  O O    . ILE A 1 71  ? -28.38642 1.31138   -4.31700  1.000 32.22137 ? 251 ILE A O    1 
ATOM   919  C CB   . ILE A 1 71  ? -27.22318 -1.01776  -2.17844  1.000 27.25690 ? 251 ILE A CB   1 
ATOM   920  C CG1  . ILE A 1 71  ? -27.63249 -1.65427  -0.84782  1.000 33.86922 ? 251 ILE A CG1  1 
ATOM   921  C CG2  . ILE A 1 71  ? -26.41792 0.24861   -1.93390  1.000 25.62026 ? 251 ILE A CG2  1 
ATOM   922  C CD1  . ILE A 1 71  ? -26.53564 -2.46313  -0.19147  1.000 34.15194 ? 251 ILE A CD1  1 
ATOM   923  H H    . ILE A 1 71  ? -28.64832 -2.50645  -3.80386  1.000 35.59910 ? 251 ILE A H    1 
ATOM   924  H HA   . ILE A 1 71  ? -29.07842 -0.17667  -2.48856  1.000 40.20381 ? 251 ILE A HA   1 
ATOM   925  H HB   . ILE A 1 71  ? -26.66712 -1.64372  -2.66821  1.000 30.44803 ? 251 ILE A HB   1 
ATOM   926  H HG12 . ILE A 1 71  ? -27.88907 -0.95018  -0.23193  1.000 41.09511 ? 251 ILE A HG12 1 
ATOM   927  H HG13 . ILE A 1 71  ? -28.38352 -2.24776  -1.00472  1.000 41.09511 ? 251 ILE A HG13 1 
ATOM   928  H HG21 . ILE A 1 71  ? -25.79057 0.08935   -1.21143  1.000 28.48407 ? 251 ILE A HG21 1 
ATOM   929  H HG22 . ILE A 1 71  ? -25.93743 0.47877   -2.74449  1.000 28.48407 ? 251 ILE A HG22 1 
ATOM   930  H HG23 . ILE A 1 71  ? -27.02401 0.96675   -1.69343  1.000 28.48407 ? 251 ILE A HG23 1 
ATOM   931  H HD11 . ILE A 1 71  ? -26.87435 -2.84293  0.63432   1.000 41.43437 ? 251 ILE A HD11 1 
ATOM   932  H HD12 . ILE A 1 71  ? -26.26249 -3.17237  -0.79418  1.000 41.43437 ? 251 ILE A HD12 1 
ATOM   933  H HD13 . ILE A 1 71  ? -25.78310 -1.88068  -0.00347  1.000 41.43437 ? 251 ILE A HD13 1 
ATOM   934  N N    . ARG A 1 72  ? -27.49314 -0.51934  -5.25491  1.000 31.13444 ? 252 ARG A N    1 
ATOM   935  C CA   . ARG A 1 72  ? -27.18119 0.13446   -6.51929  1.000 25.77340 ? 252 ARG A CA   1 
ATOM   936  C C    . ARG A 1 72  ? -27.53328 -0.80853  -7.65780  1.000 26.74706 ? 252 ARG A C    1 
ATOM   937  O O    . ARG A 1 72  ? -27.14232 -1.97933  -7.63965  1.000 27.14100 ? 252 ARG A O    1 
ATOM   938  C CB   . ARG A 1 72  ? -25.70268 0.53069   -6.59745  1.000 24.05191 ? 252 ARG A CB   1 
ATOM   939  C CG   . ARG A 1 72  ? -24.73524 -0.63608  -6.48936  1.000 23.91762 ? 252 ARG A CG   1 
ATOM   940  C CD   . ARG A 1 72  ? -23.31234 -0.15363  -6.26006  1.000 32.47144 ? 252 ARG A CD   1 
ATOM   941  N NE   . ARG A 1 72  ? -22.74351 0.45554   -7.45657  1.000 28.75637 ? 252 ARG A NE   1 
ATOM   942  C CZ   . ARG A 1 72  ? -21.48798 0.86908   -7.56391  1.000 27.10259 ? 252 ARG A CZ   1 
ATOM   943  N NH1  . ARG A 1 72  ? -20.63333 0.75438   -6.56001  1.000 30.17903 ? 252 ARG A NH1  1 
ATOM   944  N NH2  . ARG A 1 72  ? -21.07888 1.40958   -8.70823  1.000 26.42192 ? 252 ARG A NH2  1 
ATOM   945  H H    . ARG A 1 72  ? -27.23781 -1.33975  -5.21845  1.000 37.81337 ? 252 ARG A H    1 
ATOM   946  H HA   . ARG A 1 72  ? -27.71352 0.94048   -6.60795  1.000 28.66783 ? 252 ARG A HA   1 
ATOM   947  H HB2  . ARG A 1 72  ? -25.54353 0.96620   -7.44945  1.000 26.60204 ? 252 ARG A HB2  1 
ATOM   948  H HB3  . ARG A 1 72  ? -25.50731 1.14250   -5.87052  1.000 26.60204 ? 252 ARG A HB3  1 
ATOM   949  H HG2  . ARG A 1 72  ? -24.99147 -1.19881  -5.74198  1.000 26.44090 ? 252 ARG A HG2  1 
ATOM   950  H HG3  . ARG A 1 72  ? -24.75538 -1.14855  -7.31269  1.000 26.44090 ? 252 ARG A HG3  1 
ATOM   951  H HD2  . ARG A 1 72  ? -23.31017 0.50941   -5.55205  1.000 39.41778 ? 252 ARG A HD2  1 
ATOM   952  H HD3  . ARG A 1 72  ? -22.75585 -0.90777  -6.01005  1.000 39.41778 ? 252 ARG A HD3  1 
ATOM   953  H HE   . ARG A 1 72  ? -23.25728 0.55334   -8.13927  1.000 34.95970 ? 252 ARG A HE   1 
ATOM   954  H HH11 . ARG A 1 72  ? -20.88774 0.40504   -5.81648  1.000 36.66688 ? 252 ARG A HH11 1 
ATOM   955  H HH12 . ARG A 1 72  ? -19.82352 1.02917   -6.65116  1.000 36.66688 ? 252 ARG A HH12 1 
ATOM   956  H HH21 . ARG A 1 72  ? -21.62625 1.48734   -9.36696  1.000 32.15835 ? 252 ARG A HH21 1 
ATOM   957  H HH22 . ARG A 1 72  ? -20.26698 1.68130   -8.78941  1.000 32.15835 ? 252 ARG A HH22 1 
ATOM   958  N N    . GLY A 1 73  ? -28.26577 -0.29791  -8.64227  1.000 29.42060 ? 253 GLY A N    1 
ATOM   959  C CA   . GLY A 1 73  ? -28.70853 -1.08113  -9.77470  1.000 29.35995 ? 253 GLY A CA   1 
ATOM   960  C C    . GLY A 1 73  ? -27.84818 -0.97113  -11.01320 1.000 31.65422 ? 253 GLY A C    1 
ATOM   961  O O    . GLY A 1 73  ? -28.26704 -1.43847  -12.07903 1.000 42.82286 ? 253 GLY A O    1 
ATOM   962  H H    . GLY A 1 73  ? -28.52232 0.52242   -8.67138  1.000 35.75677 ? 253 GLY A H    1 
ATOM   963  H HA2  . GLY A 1 73  ? -28.73062 -2.01524  -9.51422  1.000 35.68398 ? 253 GLY A HA2  1 
ATOM   964  H HA3  . GLY A 1 73  ? -29.60518 -0.79864  -10.01370 1.000 35.68398 ? 253 GLY A HA3  1 
ATOM   965  N N    . ASP A 1 74  ? -26.66472 -0.37525  -10.91646 1.000 31.31590 ? 254 ASP A N    1 
ATOM   966  C CA   . ASP A 1 74  ? -25.80873 -0.18524  -12.07596 1.000 30.32767 ? 254 ASP A CA   1 
ATOM   967  C C    . ASP A 1 74  ? -24.84940 -1.35770  -12.24556 1.000 32.14225 ? 254 ASP A C    1 
ATOM   968  O O    . ASP A 1 74  ? -24.54449 -2.09296  -11.30303 1.000 28.75720 ? 254 ASP A O    1 
ATOM   969  C CB   . ASP A 1 74  ? -25.01122 1.11634   -11.96090 1.000 33.85686 ? 254 ASP A CB   1 
ATOM   970  C CG   . ASP A 1 74  ? -24.17018 1.17997   -10.70043 1.000 22.50276 ? 254 ASP A CG   1 
ATOM   971  O OD1  . ASP A 1 74  ? -24.55224 0.54844   -9.69412  1.000 30.71290 ? 254 ASP A OD1  1 
ATOM   972  O OD2  . ASP A 1 74  ? -23.12411 1.86210   -10.71835 1.000 22.58409 ? 254 ASP A OD2  1 
ATOM   973  H H    . ASP A 1 74  ? -26.33444 -0.07052  -10.18321 1.000 38.03113 ? 254 ASP A H    1 
ATOM   974  H HA   . ASP A 1 74  ? -26.36841 -0.13160  -12.86639 1.000 36.84525 ? 254 ASP A HA   1 
ATOM   975  H HB2  . ASP A 1 74  ? -24.41558 1.19044   -12.72289 1.000 41.08028 ? 254 ASP A HB2  1 
ATOM   976  H HB3  . ASP A 1 74  ? -25.62804 1.86484   -11.94793 1.000 41.08028 ? 254 ASP A HB3  1 
ATOM   977  N N    . LYS A 1 75  ? -24.37996 -1.52314  -13.47728 0.790 24.97565 ? 255 LYS A N    1 
ATOM   978  C CA   . LYS A 1 75  ? -23.33376 -2.47732  -13.81298 0.790 26.75437 ? 255 LYS A CA   1 
ATOM   979  C C    . LYS A 1 75  ? -22.11126 -1.70280  -14.28594 0.790 32.53822 ? 255 LYS A C    1 
ATOM   980  O O    . LYS A 1 75  ? -22.23230 -0.75363  -15.06769 0.790 28.39484 ? 255 LYS A O    1 
ATOM   981  C CB   . LYS A 1 75  ? -23.80409 -3.46231  -14.88726 0.790 32.73659 ? 255 LYS A CB   1 
ATOM   982  C CG   . LYS A 1 75  ? -24.49648 -2.81506  -16.08215 0.790 26.82173 ? 255 LYS A CG   1 
ATOM   983  C CD   . LYS A 1 75  ? -25.16426 -3.84660  -16.99043 0.790 30.97306 ? 255 LYS A CD   1 
ATOM   984  C CE   . LYS A 1 75  ? -26.29482 -4.58679  -16.28588 0.790 37.82761 ? 255 LYS A CE   1 
ATOM   985  N NZ   . LYS A 1 75  ? -27.05389 -5.46758  -17.21656 0.790 31.63382 ? 255 LYS A NZ   1 
ATOM   986  H H    . LYS A 1 75  ? -24.66243 -1.07833  -14.15695 0.790 27.71053 ? 255 LYS A H    1 
ATOM   987  H HA   . LYS A 1 75  ? -23.08608 -3.00082  -13.03483 0.790 32.55729 ? 255 LYS A HA   1 
ATOM   988  H HB2  . LYS A 1 75  ? -23.03238 -3.94503  -15.22244 0.790 39.73596 ? 255 LYS A HB2  1 
ATOM   989  H HB3  . LYS A 1 75  ? -24.43317 -4.08107  -14.48442 0.790 39.73596 ? 255 LYS A HB3  1 
ATOM   990  H HG2  . LYS A 1 75  ? -25.18065 -2.20618  -15.76266 0.790 29.92583 ? 255 LYS A HG2  1 
ATOM   991  H HG3  . LYS A 1 75  ? -23.84006 -2.33065  -16.60690 0.790 29.92583 ? 255 LYS A HG3  1 
ATOM   992  H HD2  . LYS A 1 75  ? -25.53494 -3.39635  -17.76553 0.790 37.61972 ? 255 LYS A HD2  1 
ATOM   993  H HD3  . LYS A 1 75  ? -24.50399 -4.49972  -17.27040 0.790 37.61972 ? 255 LYS A HD3  1 
ATOM   994  H HE2  . LYS A 1 75  ? -25.92309 -5.14022  -15.58130 0.790 45.84518 ? 255 LYS A HE2  1 
ATOM   995  H HE3  . LYS A 1 75  ? -26.91272 -3.94085  -15.90925 0.790 45.84518 ? 255 LYS A HE3  1 
ATOM   996  H HZ1  . LYS A 1 75  ? -27.41525 -4.98169  -17.86880 0.790 35.70035 ? 255 LYS A HZ1  1 
ATOM   997  H HZ2  . LYS A 1 75  ? -27.70293 -5.88823  -16.77622 0.790 35.70035 ? 255 LYS A HZ2  1 
ATOM   998  H HZ3  . LYS A 1 75  ? -26.50891 -6.07289  -17.57531 0.790 35.70035 ? 255 LYS A HZ3  1 
ATOM   999  N N    . ILE A 1 76  ? -20.93324 -2.09895  -13.80179 1.000 34.33976 ? 256 ILE A N    1 
ATOM   1000 C CA   . ILE A 1 76  ? -19.74056 -1.27454  -13.92442 1.000 30.45584 ? 256 ILE A CA   1 
ATOM   1001 C C    . ILE A 1 76  ? -18.56524 -2.09606  -14.43275 1.000 27.59768 ? 256 ILE A C    1 
ATOM   1002 O O    . ILE A 1 76  ? -18.57782 -3.32874  -14.42755 1.000 28.54702 ? 256 ILE A O    1 
ATOM   1003 C CB   . ILE A 1 76  ? -19.36606 -0.60670  -12.58178 1.000 27.27082 ? 256 ILE A CB   1 
ATOM   1004 C CG1  . ILE A 1 76  ? -18.78625 -1.63920  -11.60894 1.000 27.95829 ? 256 ILE A CG1  1 
ATOM   1005 C CG2  . ILE A 1 76  ? -20.58236 0.06746   -11.96616 1.000 28.79836 ? 256 ILE A CG2  1 
ATOM   1006 C CD1  . ILE A 1 76  ? -17.26887 -1.74368  -11.63707 1.000 27.60680 ? 256 ILE A CD1  1 
ATOM   1007 H H    . ILE A 1 76  ? -20.80368 -2.84637  -13.39659 0.970 41.65976 ? 256 ILE A H    1 
ATOM   1008 H HA   . ILE A 1 76  ? -19.91885 -0.59231  -14.59051 1.000 36.99905 ? 256 ILE A HA   1 
ATOM   1009 H HB   . ILE A 1 76  ? -18.69001 0.06611   -12.75840 1.000 33.17703 ? 256 ILE A HB   1 
ATOM   1010 H HG12 . ILE A 1 76  ? -19.04712 -1.39554  -10.70701 1.000 34.00200 ? 256 ILE A HG12 1 
ATOM   1011 H HG13 . ILE A 1 76  ? -19.14489 -2.51200  -11.83367 1.000 34.00200 ? 256 ILE A HG13 1 
ATOM   1012 H HG21 . ILE A 1 76  ? -20.30063 0.58388   -11.19490 1.000 35.01008 ? 256 ILE A HG21 1 
ATOM   1013 H HG22 . ILE A 1 76  ? -20.98703 0.65220   -12.62588 1.000 35.01008 ? 256 ILE A HG22 1 
ATOM   1014 H HG23 . ILE A 1 76  ? -21.21713 -0.61371  -11.69420 1.000 35.01008 ? 256 ILE A HG23 1 
ATOM   1015 H HD11 . ILE A 1 76  ? -16.95754 -2.05315  -10.77209 1.000 33.58021 ? 256 ILE A HD11 1 
ATOM   1016 H HD12 . ILE A 1 76  ? -17.00844 -2.37366  -12.32714 1.000 33.58021 ? 256 ILE A HD12 1 
ATOM   1017 H HD13 . ILE A 1 76  ? -16.89563 -0.86929  -11.82951 1.000 33.58021 ? 256 ILE A HD13 1 
ATOM   1018 N N    . THR A 1 77  ? -17.53955 -1.37459  -14.87901 1.000 34.63212 ? 257 THR A N    1 
ATOM   1019 C CA   . THR A 1 77  ? -16.23829 -1.95479  -15.18015 1.000 34.19285 ? 257 THR A CA   1 
ATOM   1020 C C    . THR A 1 77  ? -15.17138 -0.91806  -14.85501 1.000 30.45506 ? 257 THR A C    1 
ATOM   1021 O O    . THR A 1 77  ? -15.46196 0.27148   -14.70414 1.000 32.11062 ? 257 THR A O    1 
ATOM   1022 C CB   . THR A 1 77  ? -16.13295 -2.40825  -16.64247 1.000 23.84205 ? 257 THR A CB   1 
ATOM   1023 O OG1  . THR A 1 77  ? -14.98292 -3.24903  -16.80324 1.000 24.69378 ? 257 THR A OG1  1 
ATOM   1024 C CG2  . THR A 1 77  ? -16.01978 -1.21213  -17.57581 1.000 27.88836 ? 257 THR A CG2  1 
ATOM   1025 H H    . THR A 1 77  ? -17.57483 -0.52668  -15.01832 1.000 42.01059 ? 257 THR A H    1 
ATOM   1026 H HA   . THR A 1 77  ? -16.09274 -2.73657  -14.62469 1.000 41.48347 ? 257 THR A HA   1 
ATOM   1027 H HB   . THR A 1 77  ? -16.93249 -2.90227  -16.88242 1.000 29.06251 ? 257 THR A HB   1 
ATOM   1028 H HG1  . THR A 1 77  ? -15.04759 -3.92254  -16.30543 1.000 30.08459 ? 257 THR A HG1  1 
ATOM   1029 H HG21 . THR A 1 77  ? -16.19573 -1.48641  -18.48943 1.000 33.91809 ? 257 THR A HG21 1 
ATOM   1030 H HG22 . THR A 1 77  ? -16.66257 -0.53141  -17.32215 1.000 33.91809 ? 257 THR A HG22 1 
ATOM   1031 H HG23 . THR A 1 77  ? -15.12700 -0.83608  -17.52641 1.000 33.91809 ? 257 THR A HG23 1 
ATOM   1032 N N    . TRP A 1 78  ? -13.93110 -1.38166  -14.72882 1.000 24.40884 ? 258 TRP A N    1 
ATOM   1033 C CA   . TRP A 1 78  ? -12.80586 -0.52371  -14.37891 1.000 21.39426 ? 258 TRP A CA   1 
ATOM   1034 C C    . TRP A 1 78  ? -11.87096 -0.38217  -15.57176 1.000 28.99178 ? 258 TRP A C    1 
ATOM   1035 O O    . TRP A 1 78  ? -11.54148 -1.37245  -16.23367 1.000 28.19906 ? 258 TRP A O    1 
ATOM   1036 C CB   . TRP A 1 78  ? -12.04746 -1.07402  -13.16975 1.000 23.41545 ? 258 TRP A CB   1 
ATOM   1037 C CG   . TRP A 1 78  ? -12.88129 -1.13367  -11.92820 1.000 22.19080 ? 258 TRP A CG   1 
ATOM   1038 C CD1  . TRP A 1 78  ? -13.59111 -2.20338  -11.46699 1.000 22.10486 ? 258 TRP A CD1  1 
ATOM   1039 C CD2  . TRP A 1 78  ? -13.10366 -0.07112  -10.99364 1.000 18.42715 ? 258 TRP A CD2  1 
ATOM   1040 N NE1  . TRP A 1 78  ? -14.23516 -1.87569  -10.29770 1.000 19.21166 ? 258 TRP A NE1  1 
ATOM   1041 C CE2  . TRP A 1 78  ? -13.95348 -0.57118  -9.98718  1.000 29.27119 ? 258 TRP A CE2  1 
ATOM   1042 C CE3  . TRP A 1 78  ? -12.66453 1.25426   -10.90918 1.000 22.09436 ? 258 TRP A CE3  1 
ATOM   1043 C CZ2  . TRP A 1 78  ? -14.37148 0.20615   -8.90957  1.000 22.37097 ? 258 TRP A CZ2  1 
ATOM   1044 C CZ3  . TRP A 1 78  ? -13.07997 2.02313   -9.83965  1.000 15.08365 ? 258 TRP A CZ3  1 
ATOM   1045 C CH2  . TRP A 1 78  ? -13.92523 1.49753   -8.85385  1.000 26.45862 ? 258 TRP A CH2  1 
ATOM   1046 H H    . TRP A 1 78  ? -13.71387 -2.20583  -14.84353 1.000 29.74266 ? 258 TRP A H    1 
ATOM   1047 H HA   . TRP A 1 78  ? -13.13820 0.35917   -14.15317 1.000 26.12516 ? 258 TRP A HA   1 
ATOM   1048 H HB2  . TRP A 1 78  ? -11.74660 -1.97403  -13.37066 1.000 28.55059 ? 258 TRP A HB2  1 
ATOM   1049 H HB3  . TRP A 1 78  ? -11.28516 -0.50176  -12.99002 1.000 28.55059 ? 258 TRP A HB3  1 
ATOM   1050 H HD1  . TRP A 1 78  ? -13.63318 -3.03392  -11.88330 1.000 26.97788 ? 258 TRP A HD1  1 
ATOM   1051 H HE1  . TRP A 1 78  ? -14.73354 -2.40329  -9.83634  1.000 23.50605 ? 258 TRP A HE1  1 
ATOM   1052 H HE3  . TRP A 1 78  ? -12.10405 1.61061   -11.56015 1.000 26.96528 ? 258 TRP A HE3  1 
ATOM   1053 H HZ2  . TRP A 1 78  ? -14.93239 -0.13976  -8.25334  1.000 27.29721 ? 258 TRP A HZ2  1 
ATOM   1054 H HZ3  . TRP A 1 78  ? -12.79351 2.90538   -9.77275  1.000 17.63810 ? 258 TRP A HZ3  1 
ATOM   1055 H HH2  . TRP A 1 78  ? -14.18888 2.03922   -8.14536  1.000 32.20240 ? 258 TRP A HH2  1 
ATOM   1056 N N    . ILE A 1 79  ? -11.44906 0.85250   -15.83436 1.000 22.33224 ? 259 ILE A N    1 
ATOM   1057 C CA   . ILE A 1 79  ? -10.62606 1.20076   -16.98372 1.000 22.39561 ? 259 ILE A CA   1 
ATOM   1058 C C    . ILE A 1 79  ? -9.38647  1.92987   -16.48581 1.000 21.38601 ? 259 ILE A C    1 
ATOM   1059 O O    . ILE A 1 79  ? -9.49124  2.87196   -15.68961 1.000 21.24790 ? 259 ILE A O    1 
ATOM   1060 C CB   . ILE A 1 79  ? -11.39622 2.08210   -17.98733 1.000 24.46914 ? 259 ILE A CB   1 
ATOM   1061 C CG1  . ILE A 1 79  ? -12.53924 1.29791   -18.64245 1.000 26.20814 ? 259 ILE A CG1  1 
ATOM   1062 C CG2  . ILE A 1 79  ? -10.45112 2.63909   -19.04422 1.000 26.90397 ? 259 ILE A CG2  1 
ATOM   1063 C CD1  . ILE A 1 79  ? -12.12151 -0.01778  -19.26331 1.000 32.61210 ? 259 ILE A CD1  1 
ATOM   1064 H H    . ILE A 1 79  ? -11.63563 1.53075   -15.33963 1.000 27.25074 ? 259 ILE A H    1 
ATOM   1065 H HA   . ILE A 1 79  ? -10.34487 0.38889   -17.43393 1.000 27.32679 ? 259 ILE A HA   1 
ATOM   1066 H HB   . ILE A 1 79  ? -11.78393 2.82406   -17.49736 1.000 29.81501 ? 259 ILE A HB   1 
ATOM   1067 H HG12 . ILE A 1 79  ? -13.20795 1.10401   -17.96708 1.000 31.90182 ? 259 ILE A HG12 1 
ATOM   1068 H HG13 . ILE A 1 79  ? -12.92577 1.84379   -19.34495 1.000 31.90182 ? 259 ILE A HG13 1 
ATOM   1069 H HG21 . ILE A 1 79  ? -10.97106 2.93956   -19.80598 1.000 32.73682 ? 259 ILE A HG21 1 
ATOM   1070 H HG22 . ILE A 1 79  ? -9.95794  3.38378   -18.66591 1.000 32.73682 ? 259 ILE A HG22 1 
ATOM   1071 H HG23 . ILE A 1 79  ? -9.83657  1.94036   -19.31808 1.000 32.73682 ? 259 ILE A HG23 1 
ATOM   1072 H HD11 . ILE A 1 79  ? -12.79722 -0.29424  -19.90198 1.000 39.58657 ? 259 ILE A HD11 1 
ATOM   1073 H HD12 . ILE A 1 79  ? -11.27035 0.10136   -19.71302 1.000 39.58657 ? 259 ILE A HD12 1 
ATOM   1074 H HD13 . ILE A 1 79  ? -12.03551 -0.68399  -18.56355 1.000 39.58657 ? 259 ILE A HD13 1 
ATOM   1075 N N    . GLU A 1 80  ? -8.21498  1.47963   -16.94225 1.000 28.14955 ? 260 GLU A N    1 
ATOM   1076 C CA   A GLU A 1 80  ? -6.96912  2.16637   -16.62292 0.660 30.39596 ? 260 GLU A CA   1 
ATOM   1077 C CA   B GLU A 1 80  ? -6.96995  2.16702   -16.62244 0.340 30.30998 ? 260 GLU A CA   1 
ATOM   1078 C C    . GLU A 1 80  ? -6.71710  3.34449   -17.55478 1.000 26.25759 ? 260 GLU A C    1 
ATOM   1079 O O    . GLU A 1 80  ? -6.03412  4.29972   -17.16830 1.000 40.27016 ? 260 GLU A O    1 
ATOM   1080 C CB   A GLU A 1 80  ? -5.79722  1.18523   -16.69422 0.660 27.61014 ? 260 GLU A CB   1 
ATOM   1081 C CB   B GLU A 1 80  ? -5.79703  1.18808   -16.69319 0.340 27.67473 ? 260 GLU A CB   1 
ATOM   1082 C CG   A GLU A 1 80  ? -4.42962  1.85007   -16.71997 0.660 34.37801 ? 260 GLU A CG   1 
ATOM   1083 C CG   B GLU A 1 80  ? -5.87317  0.05619   -15.68285 0.340 35.43528 ? 260 GLU A CG   1 
ATOM   1084 H H    A GLU A 1 80  ? -8.11784  0.78214   -17.43588 0.660 34.23151 ? 260 GLU A H    1 
ATOM   1085 H H    B GLU A 1 80  ? -8.11758  0.78217   -17.43587 0.340 34.23151 ? 260 GLU A H    1 
ATOM   1086 H HA   A GLU A 1 80  ? -7.02177  2.50525   -15.71557 0.660 36.92720 ? 260 GLU A HA   1 
ATOM   1087 H HA   B GLU A 1 80  ? -7.02456  2.50555   -15.71507 0.340 36.82402 ? 260 GLU A HA   1 
ATOM   1088 H HB2  A GLU A 1 80  ? -5.82891  0.60702   -15.91604 0.660 33.58421 ? 260 GLU A HB2  1 
ATOM   1089 H HB2  B GLU A 1 80  ? -5.77586  0.79216   -17.57846 0.340 33.66173 ? 260 GLU A HB2  1 
ATOM   1090 H HB3  A GLU A 1 80  ? -5.88330  0.65740   -17.50346 0.660 33.58421 ? 260 GLU A HB3  1 
ATOM   1091 H HB3  B GLU A 1 80  ? -4.97498  1.67582   -16.52815 0.340 33.66173 ? 260 GLU A HB3  1 
ATOM   1092 N N    . GLY A 1 81  ? -7.25512  3.29604   -18.77361 1.000 29.45361 ? 261 GLY A N    1 
ATOM   1093 C CA   . GLY A 1 81  ? -7.09245  4.34396   -19.75796 1.000 38.75902 ? 261 GLY A CA   1 
ATOM   1094 C C    . GLY A 1 81  ? -6.18636  3.97913   -20.91459 1.000 27.71964 ? 261 GLY A C    1 
ATOM   1095 O O    . GLY A 1 81  ? -6.23322  4.64983   -21.95459 1.000 21.69453 ? 261 GLY A O    1 
ATOM   1096 H H    . GLY A 1 81  ? -7.73395  2.63951   -19.05520 1.000 35.79638 ? 261 GLY A H    1 
ATOM   1097 H HA2  . GLY A 1 81  ? -7.96303  4.56954   -20.12142 1.000 46.96287 ? 261 GLY A HA2  1 
ATOM   1098 H HA3  . GLY A 1 81  ? -6.71943  5.12657   -19.32291 1.000 46.96287 ? 261 GLY A HA3  1 
ATOM   1099 N N    . LYS A 1 82  ? -5.36683  2.93954   -20.76909 1.000 28.04569 ? 262 LYS A N    1 
ATOM   1100 C CA   . LYS A 1 82  ? -4.43553  2.52647   -21.80956 1.000 29.79251 ? 262 LYS A CA   1 
ATOM   1101 C C    . LYS A 1 82  ? -4.91967  1.32057   -22.60392 1.000 29.09845 ? 262 LYS A C    1 
ATOM   1102 O O    . LYS A 1 82  ? -4.20958  0.86811   -23.50740 1.000 28.07579 ? 262 LYS A O    1 
ATOM   1103 C CB   . LYS A 1 82  ? -3.06865  2.21357   -21.19294 1.000 39.05966 ? 262 LYS A CB   1 
ATOM   1104 C CG   . LYS A 1 82  ? -2.38123  3.41726   -20.57022 1.000 40.15187 ? 262 LYS A CG   1 
ATOM   1105 C CD   . LYS A 1 82  ? -0.97081  3.07720   -20.11738 1.000 35.97159 ? 262 LYS A CD   1 
ATOM   1106 C CE   . LYS A 1 82  ? -0.24044  4.30720   -19.60379 1.000 37.45995 ? 262 LYS A CE   1 
ATOM   1107 H H    . LYS A 1 82  ? -5.33316  2.45043   -20.06252 1.000 34.10687 ? 262 LYS A H    1 
ATOM   1108 H HA   . LYS A 1 82  ? -4.32691  3.26292   -22.43145 1.000 36.20306 ? 262 LYS A HA   1 
ATOM   1109 H HB2  . LYS A 1 82  ? -3.18657  1.54831   -20.49693 1.000 47.32364 ? 262 LYS A HB2  1 
ATOM   1110 H HB3  . LYS A 1 82  ? -2.48628  1.86766   -21.88726 1.000 47.32364 ? 262 LYS A HB3  1 
ATOM   1111 H HG2  . LYS A 1 82  ? -2.32802  4.13148   -21.22440 1.000 48.63430 ? 262 LYS A HG2  1 
ATOM   1112 H HG3  . LYS A 1 82  ? -2.88728  3.71249   -19.79713 1.000 48.63430 ? 262 LYS A HG3  1 
ATOM   1113 H HD2  . LYS A 1 82  ? -1.01174  2.42513   -19.40043 1.000 43.61796 ? 262 LYS A HD2  1 
ATOM   1114 H HD3  . LYS A 1 82  ? -0.47100  2.71606   -20.86616 1.000 43.61796 ? 262 LYS A HD3  1 
ATOM   1115 N N    . GLU A 1 83  ? -6.10099  0.79206   -22.29734 1.000 33.78236 ? 263 GLU A N    1 
ATOM   1116 C CA   . GLU A 1 83  ? -6.58600  -0.38622  -22.99571 1.000 34.14195 ? 263 GLU A CA   1 
ATOM   1117 C C    . GLU A 1 83  ? -6.95807  -0.03766  -24.43718 1.000 37.01748 ? 263 GLU A C    1 
ATOM   1118 O O    . GLU A 1 83  ? -7.41607  1.07376   -24.71669 1.000 34.76246 ? 263 GLU A O    1 
ATOM   1119 C CB   . GLU A 1 83  ? -7.80009  -0.97103  -22.27991 1.000 29.46725 ? 263 GLU A CB   1 
ATOM   1120 C CG   . GLU A 1 83  ? -7.54375  -1.36760  -20.83483 1.000 22.33397 ? 263 GLU A CG   1 
ATOM   1121 C CD   . GLU A 1 83  ? -7.85219  -0.24914  -19.85819 1.000 30.96084 ? 263 GLU A CD   1 
ATOM   1122 O OE1  . GLU A 1 83  ? -7.83564  0.92881   -20.27388 1.000 32.92105 ? 263 GLU A OE1  1 
ATOM   1123 O OE2  . GLU A 1 83  ? -8.11637  -0.54881  -18.67522 1.000 27.51166 ? 263 GLU A OE2  1 
ATOM   1124 H H    . GLU A 1 83  ? -6.63386  1.09556   -21.69440 1.000 40.99088 ? 263 GLU A H    1 
ATOM   1125 H HA   . GLU A 1 83  ? -5.88807  -1.05963  -23.01356 1.000 41.42238 ? 263 GLU A HA   1 
ATOM   1126 H HB2  . GLU A 1 83  ? -8.50908  -0.30904  -22.28154 1.000 35.81275 ? 263 GLU A HB2  1 
ATOM   1127 H HB3  . GLU A 1 83  ? -8.08719  -1.76581  -22.75615 1.000 35.81275 ? 263 GLU A HB3  1 
ATOM   1128 H HG2  . GLU A 1 83  ? -8.10562  -2.12576  -20.61033 1.000 27.25282 ? 263 GLU A HG2  1 
ATOM   1129 H HG3  . GLU A 1 83  ? -6.60896  -1.60579  -20.73313 1.000 27.25282 ? 263 GLU A HG3  1 
ATOM   1130 N N    . PRO A 1 84  ? -6.77036  -0.96915  -25.37374 1.000 28.95858 ? 264 PRO A N    1 
ATOM   1131 C CA   . PRO A 1 84  ? -7.20836  -0.71221  -26.75106 1.000 30.72059 ? 264 PRO A CA   1 
ATOM   1132 C C    . PRO A 1 84  ? -8.70994  -0.47639  -26.80777 1.000 31.20978 ? 264 PRO A C    1 
ATOM   1133 O O    . PRO A 1 84  ? -9.49057  -1.15334  -26.13535 1.000 36.81260 ? 264 PRO A O    1 
ATOM   1134 C CB   . PRO A 1 84  ? -6.80310  -1.98747  -27.50087 1.000 44.34185 ? 264 PRO A CB   1 
ATOM   1135 C CG   . PRO A 1 84  ? -6.66906  -3.03151  -26.44305 1.000 38.18754 ? 264 PRO A CG   1 
ATOM   1136 C CD   . PRO A 1 84  ? -6.17556  -2.30952  -25.22852 1.000 33.79065 ? 264 PRO A CD   1 
ATOM   1137 H HA   . PRO A 1 84  ? -6.73986  0.04777   -27.13031 1.000 37.31676 ? 264 PRO A HA   1 
ATOM   1138 H HB2  . PRO A 1 84  ? -7.49194  -2.22753  -28.14021 1.000 53.66227 ? 264 PRO A HB2  1 
ATOM   1139 H HB3  . PRO A 1 84  ? -5.95967  -1.84716  -27.95895 1.000 53.66227 ? 264 PRO A HB3  1 
ATOM   1140 H HG2  . PRO A 1 84  ? -7.53215  -3.44067  -26.27402 1.000 46.27709 ? 264 PRO A HG2  1 
ATOM   1141 H HG3  . PRO A 1 84  ? -6.03187  -3.70595  -26.72593 1.000 46.27709 ? 264 PRO A HG3  1 
ATOM   1142 H HD2  . PRO A 1 84  ? -6.48850  -2.74118  -24.41818 1.000 41.00083 ? 264 PRO A HD2  1 
ATOM   1143 H HD3  . PRO A 1 84  ? -5.20684  -2.25985  -25.22509 1.000 41.00083 ? 264 PRO A HD3  1 
ATOM   1144 N N    . GLY A 1 85  ? -9.11131  0.49425   -27.62437 1.000 38.98016 ? 265 GLY A N    1 
ATOM   1145 C CA   . GLY A 1 85  ? -10.50291 0.87557   -27.71736 1.000 36.74920 ? 265 GLY A CA   1 
ATOM   1146 C C    . GLY A 1 85  ? -11.00246 1.73581   -26.57865 1.000 30.89212 ? 265 GLY A C    1 
ATOM   1147 O O    . GLY A 1 85  ? -12.19830 2.05432   -26.54481 1.000 36.66420 ? 265 GLY A O    1 
ATOM   1148 H H    . GLY A 1 85  ? -8.58770  0.94601   -28.13560 1.000 47.22824 ? 265 GLY A H    1 
ATOM   1149 H HA2  . GLY A 1 85  ? -10.63537 1.36938   -28.54168 1.000 44.55109 ? 265 GLY A HA2  1 
ATOM   1150 H HA3  . GLY A 1 85  ? -11.04460 0.07125   -27.74053 1.000 44.55109 ? 265 GLY A HA3  1 
ATOM   1151 N N    . CYS A 1 86  ? -10.13070 2.11829   -25.64426 1.000 34.61516 ? 266 CYS A N    1 
ATOM   1152 C CA   . CYS A 1 86  ? -10.47987 2.98869   -24.52801 1.000 34.56629 ? 266 CYS A CA   1 
ATOM   1153 C C    . CYS A 1 86  ? -9.60208  4.23670   -24.51651 1.000 23.35237 ? 266 CYS A C    1 
ATOM   1154 O O    . CYS A 1 86  ? -9.37491  4.83874   -23.46558 1.000 30.91470 ? 266 CYS A O    1 
ATOM   1155 C CB   . CYS A 1 86  ? -10.35949 2.23699   -23.20268 1.000 25.73614 ? 266 CYS A CB   1 
ATOM   1156 S SG   . CYS A 1 86  ? -11.53735 0.87751   -23.00473 1.000 30.11495 ? 266 CYS A SG   1 
ATOM   1157 H H    . CYS A 1 86  ? -9.30523  1.87713   -25.63802 1.000 41.99024 ? 266 CYS A H    1 
ATOM   1158 H HA   . CYS A 1 86  ? -11.40247 3.27155   -24.62650 1.000 41.93159 ? 266 CYS A HA   1 
ATOM   1159 H HB2  . CYS A 1 86  ? -9.46661  1.86332   -23.13911 1.000 31.33542 ? 266 CYS A HB2  1 
ATOM   1160 H HB3  . CYS A 1 86  ? -10.50946 2.86323   -22.47726 1.000 31.33542 ? 266 CYS A HB3  1 
ATOM   1161 H HG   . CYS A 1 86  ? -11.33655 0.33670   -21.95249 1.000 36.58999 ? 266 CYS A HG   1 
ATOM   1162 N N    . GLU A 1 87  ? -9.10079  4.63056   -25.68943 1.000 38.20677 ? 267 GLU A N    1 
ATOM   1163 C CA   . GLU A 1 87  ? -8.14484  5.73100   -25.76164 1.000 29.26665 ? 267 GLU A CA   1 
ATOM   1164 C C    . GLU A 1 87  ? -8.78326  7.05872   -25.36918 1.000 20.27864 ? 267 GLU A C    1 
ATOM   1165 O O    . GLU A 1 87  ? -8.16724  7.86333   -24.65938 1.000 25.57170 ? 267 GLU A O    1 
ATOM   1166 C CB   . GLU A 1 87  ? -7.55878  5.81054   -27.17126 1.000 34.93980 ? 267 GLU A CB   1 
ATOM   1167 C CG   . GLU A 1 87  ? -6.66199  4.63149   -27.53335 1.000 38.29894 ? 267 GLU A CG   1 
ATOM   1168 C CD   . GLU A 1 87  ? -7.42528  3.46269   -28.13671 1.000 33.35189 ? 267 GLU A CD   1 
ATOM   1169 O OE1  . GLU A 1 87  ? -8.63095  3.61224   -28.42857 1.000 37.05910 ? 267 GLU A OE1  1 
ATOM   1170 O OE2  . GLU A 1 87  ? -6.81514  2.38862   -28.31957 1.000 39.99994 ? 267 GLU A OE2  1 
ATOM   1171 H H    . GLU A 1 87  ? -9.29686  4.27976   -26.44976 1.000 46.30017 ? 267 GLU A H    1 
ATOM   1172 H HA   . GLU A 1 87  ? -7.42210  5.55863   -25.13807 1.000 35.57202 ? 267 GLU A HA   1 
ATOM   1173 H HB2  . GLU A 1 87  ? -8.28774  5.83505   -27.81073 1.000 42.37981 ? 267 GLU A HB2  1 
ATOM   1174 H HB3  . GLU A 1 87  ? -7.02759  6.61903   -27.24257 1.000 42.37981 ? 267 GLU A HB3  1 
ATOM   1175 H HG2  . GLU A 1 87  ? -6.00367  4.92475   -28.18259 1.000 46.41078 ? 267 GLU A HG2  1 
ATOM   1176 H HG3  . GLU A 1 87  ? -6.21844  4.31551   -26.73066 1.000 46.41078 ? 267 GLU A HG3  1 
ATOM   1177 N N    . THR A 1 88  ? -10.01320 7.31314   -25.82215 1.000 26.69500 ? 268 THR A N    1 
ATOM   1178 C CA   . THR A 1 88  ? -10.66062 8.57815   -25.48899 1.000 21.27444 ? 268 THR A CA   1 
ATOM   1179 C C    . THR A 1 88  ? -11.04799 8.63327   -24.01595 1.000 28.15616 ? 268 THR A C    1 
ATOM   1180 O O    . THR A 1 88  ? -11.03145 9.71167   -23.40978 1.000 23.17218 ? 268 THR A O    1 
ATOM   1181 C CB   . THR A 1 88  ? -11.88766 8.79889   -26.37258 1.000 33.45075 ? 268 THR A CB   1 
ATOM   1182 O OG1  . THR A 1 88  ? -11.60551 8.36346   -27.70846 1.000 27.32722 ? 268 THR A OG1  1 
ATOM   1183 C CG2  . THR A 1 88  ? -12.25031 10.27434  -26.40646 1.000 23.06482 ? 268 THR A CG2  1 
ATOM   1184 H H    . THR A 1 88  ? -10.48107 6.78274   -26.31141 1.000 32.48605 ? 268 THR A H    1 
ATOM   1185 H HA   . THR A 1 88  ? -10.03907 9.30157   -25.66571 1.000 25.98138 ? 268 THR A HA   1 
ATOM   1186 H HB   . THR A 1 88  ? -12.63678 8.29602   -26.01643 1.000 40.59295 ? 268 THR A HB   1 
ATOM   1187 H HG1  . THR A 1 88  ? -11.53497 7.52668   -27.72903 1.000 33.24471 ? 268 THR A HG1  1 
ATOM   1188 H HG21 . THR A 1 88  ? -13.09786 10.39727  -26.86192 1.000 28.12983 ? 268 THR A HG21 1 
ATOM   1189 H HG22 . THR A 1 88  ? -12.32586 10.61824  -25.50263 1.000 28.12983 ? 268 THR A HG22 1 
ATOM   1190 H HG23 . THR A 1 88  ? -11.56472 10.77376  -26.87703 1.000 28.12983 ? 268 THR A HG23 1 
ATOM   1191 N N    . ILE A 1 89  ? -11.39620 7.48981   -23.42291 1.000 23.20852 ? 269 ILE A N    1 
ATOM   1192 C CA   . ILE A 1 89  ? -11.59126 7.44284   -21.97699 1.000 24.94998 ? 269 ILE A CA   1 
ATOM   1193 C C    . ILE A 1 89  ? -10.29372 7.80486   -21.26624 1.000 20.64375 ? 269 ILE A C    1 
ATOM   1194 O O    . ILE A 1 89  ? -10.29729 8.51483   -20.25302 1.000 22.87253 ? 269 ILE A O    1 
ATOM   1195 C CB   . ILE A 1 89  ? -12.10639 6.05576   -21.54873 1.000 22.73985 ? 269 ILE A CB   1 
ATOM   1196 C CG1  . ILE A 1 89  ? -13.46867 5.76937   -22.18537 1.000 34.46670 ? 269 ILE A CG1  1 
ATOM   1197 C CG2  . ILE A 1 89  ? -12.21170 5.96869   -20.03238 1.000 29.94309 ? 269 ILE A CG2  1 
ATOM   1198 C CD1  . ILE A 1 89  ? -13.75776 4.29407   -22.36738 1.000 39.89285 ? 269 ILE A CD1  1 
ATOM   1199 H H    . ILE A 1 89  ? -11.52303 6.74206   -23.82837 1.000 28.30228 ? 269 ILE A H    1 
ATOM   1200 H HA   . ILE A 1 89  ? -12.26512 8.09580   -21.73114 1.000 30.39202 ? 269 ILE A HA   1 
ATOM   1201 H HB   . ILE A 1 89  ? -11.47075 5.39130   -21.85752 1.000 27.73987 ? 269 ILE A HB   1 
ATOM   1202 H HG12 . ILE A 1 89  ? -14.16252 6.13933   -21.61740 1.000 41.81209 ? 269 ILE A HG12 1 
ATOM   1203 H HG13 . ILE A 1 89  ? -13.49827 6.18718   -23.06027 1.000 41.81209 ? 269 ILE A HG13 1 
ATOM   1204 H HG21 . ILE A 1 89  ? -12.72710 5.18160   -19.79629 1.000 36.38375 ? 269 ILE A HG21 1 
ATOM   1205 H HG22 . ILE A 1 89  ? -11.31957 5.90475   -19.65701 1.000 36.38375 ? 269 ILE A HG22 1 
ATOM   1206 H HG23 . ILE A 1 89  ? -12.65397 6.76556   -19.70026 1.000 36.38375 ? 269 ILE A HG23 1 
ATOM   1207 H HD11 . ILE A 1 89  ? -14.63176 4.19151   -22.77542 1.000 48.32347 ? 269 ILE A HD11 1 
ATOM   1208 H HD12 . ILE A 1 89  ? -13.07759 3.90737   -22.94074 1.000 48.32347 ? 269 ILE A HD12 1 
ATOM   1209 H HD13 . ILE A 1 89  ? -13.74477 3.86034   -21.49985 1.000 48.32347 ? 269 ILE A HD13 1 
ATOM   1210 N N    . GLY A 1 90  ? -9.16280  7.32409   -21.78659 1.000 24.00324 ? 270 GLY A N    1 
ATOM   1211 C CA   . GLY A 1 90  ? -7.88027  7.72027   -21.23036 1.000 24.24528 ? 270 GLY A CA   1 
ATOM   1212 C C    . GLY A 1 90  ? -7.62644  9.20940   -21.36397 1.000 19.43428 ? 270 GLY A C    1 
ATOM   1213 O O    . GLY A 1 90  ? -7.06278  9.83604   -20.46479 1.000 35.50072 ? 270 GLY A O    1 
ATOM   1214 H H    . GLY A 1 90  ? -9.11580  6.77777   -22.44911 1.000 29.25593 ? 270 GLY A H    1 
ATOM   1215 H HA2  . GLY A 1 90  ? -7.85387  7.48915   -20.28867 1.000 29.54639 ? 270 GLY A HA2  1 
ATOM   1216 H HA3  . GLY A 1 90  ? -7.17048  7.24677   -21.69177 1.000 29.54639 ? 270 GLY A HA3  1 
ATOM   1217 N N    . LEU A 1 91  ? -8.03130  9.79518   -22.49261 1.000 25.35663 ? 271 LEU A N    1 
ATOM   1218 C CA   . LEU A 1 91  ? -7.89529  11.23990  -22.66345 1.000 21.31175 ? 271 LEU A CA   1 
ATOM   1219 C C    . LEU A 1 91  ? -8.72494  11.99237  -21.63000 1.000 19.80191 ? 271 LEU A C    1 
ATOM   1220 O O    . LEU A 1 91  ? -8.25520  12.96800  -21.03011 1.000 23.48242 ? 271 LEU A O    1 
ATOM   1221 C CB   . LEU A 1 91  ? -8.31399  11.63745  -24.08006 1.000 23.06298 ? 271 LEU A CB   1 
ATOM   1222 C CG   . LEU A 1 91  ? -8.09733  13.08627  -24.53494 1.000 32.35970 ? 271 LEU A CG   1 
ATOM   1223 C CD1  . LEU A 1 91  ? -9.32406  13.94232  -24.23532 1.000 24.09170 ? 271 LEU A CD1  1 
ATOM   1224 C CD2  . LEU A 1 91  ? -6.85187  13.69824  -23.91012 1.000 26.20637 ? 271 LEU A CD2  1 
ATOM   1225 H H    . LEU A 1 91  ? -8.38186  9.38561   -23.16266 1.000 30.88000 ? 271 LEU A H    1 
ATOM   1226 H HA   . LEU A 1 91  ? -6.96516  11.48731  -22.54282 1.000 26.02615 ? 271 LEU A HA   1 
ATOM   1227 H HB2  . LEU A 1 91  ? -7.81832  11.07795  -24.69827 1.000 28.12762 ? 271 LEU A HB2  1 
ATOM   1228 H HB3  . LEU A 1 91  ? -9.26443  11.46226  -24.16300 1.000 28.12762 ? 271 LEU A HB3  1 
ATOM   1229 H HG   . LEU A 1 91  ? -7.96131  13.07663  -25.49530 1.000 39.28369 ? 271 LEU A HG   1 
ATOM   1230 H HD11 . LEU A 1 91  ? -9.19267  14.82580  -24.61360 1.000 29.36209 ? 271 LEU A HD11 1 
ATOM   1231 H HD12 . LEU A 1 91  ? -10.10474 13.52531  -24.63222 1.000 29.36209 ? 271 LEU A HD12 1 
ATOM   1232 H HD13 . LEU A 1 91  ? -9.43657  14.00746  -23.27407 1.000 29.36209 ? 271 LEU A HD13 1 
ATOM   1233 H HD21 . LEU A 1 91  ? -6.68915  14.56494  -24.31417 1.000 31.89970 ? 271 LEU A HD21 1 
ATOM   1234 H HD22 . LEU A 1 91  ? -6.99443  13.79959  -22.95603 1.000 31.89970 ? 271 LEU A HD22 1 
ATOM   1235 H HD23 . LEU A 1 91  ? -6.09670  13.11116  -24.07122 1.000 31.89970 ? 271 LEU A HD23 1 
ATOM   1236 N N    . LEU A 1 92  ? -9.96570  11.55259  -21.41297 1.000 19.04212 ? 272 LEU A N    1 
ATOM   1237 C CA   . LEU A 1 92  ? -10.80762 12.17426  -20.39391 1.000 19.78493 ? 272 LEU A CA   1 
ATOM   1238 C C    . LEU A 1 92  ? -10.16886 12.05485  -19.01558 1.000 21.61086 ? 272 LEU A C    1 
ATOM   1239 O O    . LEU A 1 92  ? -10.16551 13.01369  -18.23079 1.000 14.00884 ? 272 LEU A O    1 
ATOM   1240 C CB   . LEU A 1 92  ? -12.19287 11.52414  -20.40739 1.000 20.59180 ? 272 LEU A CB   1 
ATOM   1241 C CG   . LEU A 1 92  ? -13.09229 11.67159  -19.17733 1.000 23.68873 ? 272 LEU A CG   1 
ATOM   1242 C CD1  . LEU A 1 92  ? -13.63034 13.09029  -19.07176 1.000 23.16788 ? 272 LEU A CD1  1 
ATOM   1243 C CD2  . LEU A 1 92  ? -14.22815 10.65651  -19.23235 1.000 16.16226 ? 272 LEU A CD2  1 
ATOM   1244 H H    . LEU A 1 92  ? -10.33878 10.90402  -21.83695 1.000 23.30259 ? 272 LEU A H    1 
ATOM   1245 H HA   . LEU A 1 92  ? -10.91432 13.11732  -20.59430 1.000 24.19397 ? 272 LEU A HA   1 
ATOM   1246 H HB2  . LEU A 1 92  ? -12.68420 11.90205  -21.15350 1.000 25.16221 ? 272 LEU A HB2  1 
ATOM   1247 H HB3  . LEU A 1 92  ? -12.06592 10.57195  -20.54197 1.000 25.16221 ? 272 LEU A HB3  1 
ATOM   1248 H HG   . LEU A 1 92  ? -12.57262 11.49726  -18.37705 1.000 28.87853 ? 272 LEU A HG   1 
ATOM   1249 H HD11 . LEU A 1 92  ? -14.30639 13.12074  -18.37684 1.000 28.25350 ? 272 LEU A HD11 1 
ATOM   1250 H HD12 . LEU A 1 92  ? -12.90035 13.68916  -18.84956 1.000 28.25350 ? 272 LEU A HD12 1 
ATOM   1251 H HD13 . LEU A 1 92  ? -14.01941 13.34465  -19.92313 1.000 28.25350 ? 272 LEU A HD13 1 
ATOM   1252 H HD21 . LEU A 1 92  ? -14.78358 10.76107  -18.44401 1.000 17.47181 ? 272 LEU A HD21 1 
ATOM   1253 H HD22 . LEU A 1 92  ? -14.75478 10.81488  -20.03140 1.000 17.47181 ? 272 LEU A HD22 1 
ATOM   1254 H HD23 . LEU A 1 92  ? -13.85206 9.76270   -19.25582 1.000 17.47181 ? 272 LEU A HD23 1 
ATOM   1255 N N    . MET A 1 93  ? -9.62713  10.87674  -18.70482 1.000 20.67769 ? 273 MET A N    1 
ATOM   1256 C CA   . MET A 1 93  ? -8.97444  10.66900  -17.41877 1.000 13.89359 ? 273 MET A CA   1 
ATOM   1257 C C    . MET A 1 93  ? -7.77909  11.59935  -17.25569 1.000 13.13684 ? 273 MET A C    1 
ATOM   1258 O O    . MET A 1 93  ? -7.57340  12.18346  -16.18408 1.000 15.49889 ? 273 MET A O    1 
ATOM   1259 C CB   . MET A 1 93  ? -8.54301  9.20739   -17.30404 1.000 16.92803 ? 273 MET A CB   1 
ATOM   1260 C CG   . MET A 1 93  ? -9.69571  8.24822   -17.05252 1.000 26.79521 ? 273 MET A CG   1 
ATOM   1261 S SD   . MET A 1 93  ? -9.19709  6.51691   -17.12181 1.000 19.41763 ? 273 MET A SD   1 
ATOM   1262 C CE   . MET A 1 93  ? -8.10336  6.42208   -15.70943 1.000 18.74499 ? 273 MET A CE   1 
ATOM   1263 H H    . MET A 1 93  ? -9.62493  10.18720  -19.21875 1.000 25.26528 ? 273 MET A H    1 
ATOM   1264 H HA   . MET A 1 93  ? -9.60553  10.85458  -16.70589 1.000 17.12436 ? 273 MET A HA   1 
ATOM   1265 H HB2  . MET A 1 93  ? -8.11275  8.94309   -18.13224 1.000 20.76568 ? 273 MET A HB2  1 
ATOM   1266 H HB3  . MET A 1 93  ? -7.92039  9.12288   -16.56505 1.000 20.76568 ? 273 MET A HB3  1 
ATOM   1267 H HG2  . MET A 1 93  ? -10.06151 8.41916   -16.17055 1.000 32.60630 ? 273 MET A HG2  1 
ATOM   1268 H HG3  . MET A 1 93  ? -10.37744 8.39050   -17.72772 1.000 32.60630 ? 273 MET A HG3  1 
ATOM   1269 H HE1  . MET A 1 93  ? -7.85847  5.49526   -15.56131 1.000 22.94604 ? 273 MET A HE1  1 
ATOM   1270 H HE2  . MET A 1 93  ? -7.30925  6.94939   -15.88898 1.000 22.94604 ? 273 MET A HE2  1 
ATOM   1271 H HE3  . MET A 1 93  ? -8.56309  6.77136   -14.92998 1.000 22.94604 ? 273 MET A HE3  1 
ATOM   1272 N N    . SER A 1 94  ? -6.97839  11.74691  -18.31255 1.000 24.49107 ? 274 SER A N    1 
ATOM   1273 C CA   . SER A 1 94  ? -5.81764  12.62692  -18.25321 1.000 21.93112 ? 274 SER A CA   1 
ATOM   1274 C C    . SER A 1 94  ? -6.23494  14.08224  -18.08520 1.000 16.72408 ? 274 SER A C    1 
ATOM   1275 O O    . SER A 1 94  ? -5.55764  14.84774  -17.39527 1.000 19.26116 ? 274 SER A O    1 
ATOM   1276 C CB   . SER A 1 94  ? -4.96654  12.45525  -19.51024 1.000 27.52668 ? 274 SER A CB   1 
ATOM   1277 O OG   . SER A 1 94  ? -4.08898  13.55447  -19.68200 1.000 46.70637 ? 274 SER A OG   1 
ATOM   1278 H H    . SER A 1 94  ? -7.08575  11.35136  -19.06860 1.000 29.84133 ? 274 SER A H    1 
ATOM   1279 H HA   . SER A 1 94  ? -5.27701  12.37928  -17.48686 1.000 26.76939 ? 274 SER A HA   1 
ATOM   1280 H HB2  . SER A 1 94  ? -4.44241  11.64323  -19.42770 1.000 33.48407 ? 274 SER A HB2  1 
ATOM   1281 H HB3  . SER A 1 94  ? -5.55173  12.39544  -20.28152 1.000 33.48407 ? 274 SER A HB3  1 
ATOM   1282 H HG   . SER A 1 94  ? -3.62051  13.44327  -20.37030 1.000 56.49970 ? 274 SER A HG   1 
ATOM   1283 N N    . SER A 1 95  ? -7.33543  14.48935  -18.71951 1.000 20.89602 ? 275 SER A N    1 
ATOM   1284 C CA   . SER A 1 95  ? -7.83728  15.84762  -18.52201 1.000 21.78663 ? 275 SER A CA   1 
ATOM   1285 C C    . SER A 1 95  ? -8.25684  16.06613  -17.07145 1.000 14.64385 ? 275 SER A C    1 
ATOM   1286 O O    . SER A 1 95  ? -7.93655  17.09750  -16.45929 1.000 27.37932 ? 275 SER A O    1 
ATOM   1287 C CB   . SER A 1 95  ? -9.00835  16.10991  -19.46859 1.000 23.33480 ? 275 SER A CB   1 
ATOM   1288 O OG   . SER A 1 95  ? -8.59008  16.05509  -20.82150 1.000 19.87950 ? 275 SER A OG   1 
ATOM   1289 H H    . SER A 1 95  ? -7.80088  14.00790  -19.25911 1.000 25.52728 ? 275 SER A H    1 
ATOM   1290 H HA   . SER A 1 95  ? -7.13229  16.48017  -18.73125 1.000 26.59600 ? 275 SER A HA   1 
ATOM   1291 H HB2  . SER A 1 95  ? -9.68947  15.43507  -19.32174 1.000 28.45381 ? 275 SER A HB2  1 
ATOM   1292 H HB3  . SER A 1 95  ? -9.36981  16.99133  -19.28598 1.000 28.45381 ? 275 SER A HB3  1 
ATOM   1293 H HG   . SER A 1 95  ? -8.27514  15.29578  -20.99430 1.000 24.30744 ? 275 SER A HG   1 
ATOM   1294 N N    . MET A 1 96  ? -8.98163  15.09735  -16.50604 1.000 25.96541 ? 276 MET A N    1 
ATOM   1295 C CA   . MET A 1 96  ? -9.35097  15.17334  -15.09600 1.000 19.35364 ? 276 MET A CA   1 
ATOM   1296 C C    . MET A 1 96  ? -8.10911  15.33981  -14.22831 1.000 23.80331 ? 276 MET A C    1 
ATOM   1297 O O    . MET A 1 96  ? -8.05017  16.21346  -13.34963 1.000 17.91799 ? 276 MET A O    1 
ATOM   1298 C CB   . MET A 1 96  ? -10.10954 13.90886  -14.68752 1.000 12.74141 ? 276 MET A CB   1 
ATOM   1299 C CG   . MET A 1 96  ? -11.54994 13.82261  -15.16140 1.000 23.75126 ? 276 MET A CG   1 
ATOM   1300 S SD   . MET A 1 96  ? -12.19062 12.15246  -14.89903 1.000 23.73638 ? 276 MET A SD   1 
ATOM   1301 C CE   . MET A 1 96  ? -13.91526 12.34488  -15.33885 1.000 27.91318 ? 276 MET A CE   1 
ATOM   1302 H H    . MET A 1 96  ? -9.26735  14.39566  -16.91298 1.000 31.61054 ? 276 MET A H    1 
ATOM   1303 H HA   . MET A 1 96  ? -9.94002  15.93333  -14.96818 1.000 23.67642 ? 276 MET A HA   1 
ATOM   1304 H HB2  . MET A 1 96  ? -9.64045  13.14179  -15.05145 1.000 15.74174 ? 276 MET A HB2  1 
ATOM   1305 H HB3  . MET A 1 96  ? -10.12197 13.86118  -13.71877 1.000 15.74174 ? 276 MET A HB3  1 
ATOM   1306 H HG2  . MET A 1 96  ? -12.09638 14.44790  -14.66009 1.000 28.95356 ? 276 MET A HG2  1 
ATOM   1307 H HG3  . MET A 1 96  ? -11.59476 14.02797  -16.10835 1.000 28.95356 ? 276 MET A HG3  1 
ATOM   1308 H HE1  . MET A 1 96  ? -14.36325 11.49004  -15.24158 1.000 33.94787 ? 276 MET A HE1  1 
ATOM   1309 H HE2  . MET A 1 96  ? -14.32044 12.99968  -14.74897 1.000 33.94787 ? 276 MET A HE2  1 
ATOM   1310 H HE3  . MET A 1 96  ? -13.97479 12.64674  -16.25876 1.000 33.94787 ? 276 MET A HE3  1 
ATOM   1311 N N    . ASP A 1 97  ? -7.09967  14.50030  -14.47425 1.000 24.10340 ? 277 ASP A N    1 
ATOM   1312 C CA   . ASP A 1 97  ? -5.87095  14.55062  -13.69151 1.000 12.54028 ? 277 ASP A CA   1 
ATOM   1313 C C    . ASP A 1 97  ? -5.16474  15.88895  -13.86122 1.000 16.99146 ? 277 ASP A C    1 
ATOM   1314 O O    . ASP A 1 97  ? -4.57565  16.41129  -12.91126 1.000 29.28949 ? 277 ASP A O    1 
ATOM   1315 C CB   . ASP A 1 97  ? -4.94521  13.40630  -14.10357 1.000 12.42766 ? 277 ASP A CB   1 
ATOM   1316 C CG   . ASP A 1 97  ? -5.50682  12.04260  -13.74992 1.000 25.10662 ? 277 ASP A CG   1 
ATOM   1317 O OD1  . ASP A 1 97  ? -6.51366  11.98046  -13.01298 1.000 14.35617 ? 277 ASP A OD1  1 
ATOM   1318 O OD2  . ASP A 1 97  ? -4.94258  11.02766  -14.21253 1.000 24.29596 ? 277 ASP A OD2  1 
ATOM   1319 H H    . ASP A 1 97  ? -7.10356  13.89615  -15.08629 1.000 29.37613 ? 277 ASP A H    1 
ATOM   1320 H HA   . ASP A 1 97  ? -6.09205  14.44188  -12.75333 1.000 15.50039 ? 277 ASP A HA   1 
ATOM   1321 H HB2  . ASP A 1 97  ? -4.81306  13.43660  -15.06405 1.000 15.36524 ? 277 ASP A HB2  1 
ATOM   1322 H HB3  . ASP A 1 97  ? -4.09474  13.50792  -13.64830 1.000 15.36524 ? 277 ASP A HB3  1 
ATOM   1323 N N    . ASP A 1 98  ? -5.19234  16.44614  -15.07161 1.000 13.81357 ? 278 ASP A N    1 
ATOM   1324 C CA   . ASP A 1 98  ? -4.56601  17.74176  -15.31397 1.000 18.20497 ? 278 ASP A CA   1 
ATOM   1325 C C    . ASP A 1 98  ? -5.21897  18.82353  -14.46552 1.000 20.69053 ? 278 ASP A C    1 
ATOM   1326 O O    . ASP A 1 98  ? -4.53372  19.63306  -13.82392 1.000 19.28902 ? 278 ASP A O    1 
ATOM   1327 C CB   . ASP A 1 98  ? -4.66286  18.08676  -16.80097 1.000 21.86128 ? 278 ASP A CB   1 
ATOM   1328 C CG   . ASP A 1 98  ? -3.88754  19.33592  -17.16550 1.000 20.88087 ? 278 ASP A CG   1 
ATOM   1329 O OD1  . ASP A 1 98  ? -2.93368  19.68091  -16.43888 1.000 28.71165 ? 278 ASP A OD1  1 
ATOM   1330 O OD2  . ASP A 1 98  ? -4.23721  19.97475  -18.17991 1.000 33.11269 ? 278 ASP A OD2  1 
ATOM   1331 H H    . ASP A 1 98  ? -5.56453  16.09690  -15.76378 1.000 17.02833 ? 278 ASP A H    1 
ATOM   1332 H HA   . ASP A 1 98  ? -3.62747  17.69563  -15.07330 1.000 22.29802 ? 278 ASP A HA   1 
ATOM   1333 H HB2  . ASP A 1 98  ? -4.30510  17.34970  -17.32025 1.000 26.68558 ? 278 ASP A HB2  1 
ATOM   1334 H HB3  . ASP A 1 98  ? -5.59360  18.23379  -17.03120 1.000 26.68558 ? 278 ASP A HB3  1 
ATOM   1335 N N    . LEU A 1 99  ? -6.55278  18.84421  -14.43936 1.000 22.43235 ? 279 LEU A N    1 
ATOM   1336 C CA   . LEU A 1 99  ? -7.24313  19.81939  -13.59826 1.000 22.53940 ? 279 LEU A CA   1 
ATOM   1337 C C    . LEU A 1 99  ? -6.88014  19.62311  -12.12866 1.000 23.11196 ? 279 LEU A C    1 
ATOM   1338 O O    . LEU A 1 99  ? -6.55863  20.58570  -11.41822 1.000 21.56940 ? 279 LEU A O    1 
ATOM   1339 C CB   . LEU A 1 99  ? -8.75789  19.72548  -13.79741 1.000 12.76425 ? 279 LEU A CB   1 
ATOM   1340 C CG   . LEU A 1 99  ? -9.37388  20.39047  -15.03607 1.000 20.30608 ? 279 LEU A CG   1 
ATOM   1341 C CD1  . LEU A 1 99  ? -8.75411  19.93750  -16.34987 1.000 35.06272 ? 279 LEU A CD1  1 
ATOM   1342 C CD2  . LEU A 1 99  ? -10.87832 20.14658  -15.05390 1.000 25.27086 ? 279 LEU A CD2  1 
ATOM   1343 H H    . LEU A 1 99  ? -7.06636  18.31911  -14.88669 1.000 27.37087 ? 279 LEU A H    1 
ATOM   1344 H HA   . LEU A 1 99  ? -6.96629  20.70943  -13.86675 1.000 27.49932 ? 279 LEU A HA   1 
ATOM   1345 H HB2  . LEU A 1 99  ? -8.98940  18.78468  -13.84436 1.000 15.76914 ? 279 LEU A HB2  1 
ATOM   1346 H HB3  . LEU A 1 99  ? -9.18066  20.13304  -13.02536 1.000 15.76914 ? 279 LEU A HB3  1 
ATOM   1347 H HG   . LEU A 1 99  ? -9.18890  21.34055  -14.97252 1.000 24.81934 ? 279 LEU A HG   1 
ATOM   1348 H HD11 . LEU A 1 99  ? -8.98550  20.57405  -17.04425 1.000 42.52732 ? 279 LEU A HD11 1 
ATOM   1349 H HD12 . LEU A 1 99  ? -7.79049  19.89617  -16.24679 1.000 42.52732 ? 279 LEU A HD12 1 
ATOM   1350 H HD13 . LEU A 1 99  ? -9.10046  19.06026  -16.57656 1.000 42.52732 ? 279 LEU A HD13 1 
ATOM   1351 H HD21 . LEU A 1 99  ? -11.26837 20.63328  -15.79679 1.000 30.77708 ? 279 LEU A HD21 1 
ATOM   1352 H HD22 . LEU A 1 99  ? -11.04299 19.19635  -15.15807 1.000 30.77708 ? 279 LEU A HD22 1 
ATOM   1353 H HD23 . LEU A 1 99  ? -11.25874 20.45851  -14.21791 1.000 30.77708 ? 279 LEU A HD23 1 
ATOM   1354 N N    . ILE A 1 100 ? -6.89966  18.37438  -11.65750 1.000 22.45230 ? 280 ILE A N    1 
ATOM   1355 C CA   . ILE A 1 100 ? -6.61156  18.13087  -10.24464 1.000 9.84951  ? 280 ILE A CA   1 
ATOM   1356 C C    . ILE A 1 100 ? -5.18898  18.56498  -9.90516  1.000 11.81401 ? 280 ILE A C    1 
ATOM   1357 O O    . ILE A 1 100 ? -4.94479  19.17226  -8.85492  1.000 11.15073 ? 280 ILE A O    1 
ATOM   1358 C CB   . ILE A 1 100 ? -6.85892  16.65323  -9.88918  1.000 9.64764  ? 280 ILE A CB   1 
ATOM   1359 C CG1  . ILE A 1 100 ? -8.36386  16.36134  -9.83250  1.000 18.21922 ? 280 ILE A CG1  1 
ATOM   1360 C CG2  . ILE A 1 100 ? -6.19143  16.29951  -8.56451  1.000 10.69000 ? 280 ILE A CG2  1 
ATOM   1361 C CD1  . ILE A 1 100 ? -9.14900  17.23882  -8.86964  1.000 19.68577 ? 280 ILE A CD1  1 
ATOM   1362 H H    . ILE A 1 100 ? -7.07186  17.67120  -12.12171 1.000 27.39480 ? 280 ILE A H    1 
ATOM   1363 H HA   . ILE A 1 100 ? -7.21970  18.66775  -9.71282  1.000 11.52723 ? 280 ILE A HA   1 
ATOM   1364 H HB   . ILE A 1 100 ? -6.46557  16.10330  -10.58471 1.000 11.46288 ? 280 ILE A HB   1 
ATOM   1365 H HG12 . ILE A 1 100 ? -8.73665  16.49434  -10.71807 1.000 22.31512 ? 280 ILE A HG12 1 
ATOM   1366 H HG13 . ILE A 1 100 ? -8.48840  15.44026  -9.55502  1.000 22.31512 ? 280 ILE A HG13 1 
ATOM   1367 H HG21 . ILE A 1 100 ? -6.58143  15.47947  -8.22342  1.000 13.28005 ? 280 ILE A HG21 1 
ATOM   1368 H HG22 . ILE A 1 100 ? -5.24069  16.17695  -8.71276  1.000 13.28005 ? 280 ILE A HG22 1 
ATOM   1369 H HG23 . ILE A 1 100 ? -6.33747  17.02234  -7.93436  1.000 13.28005 ? 280 ILE A HG23 1 
ATOM   1370 H HD11 . ILE A 1 100 ? -9.99913  16.81355  -8.67643  1.000 24.07498 ? 280 ILE A HD11 1 
ATOM   1371 H HD12 . ILE A 1 100 ? -8.63879  17.34506  -8.05154  1.000 24.07498 ? 280 ILE A HD12 1 
ATOM   1372 H HD13 . ILE A 1 100 ? -9.29814  18.10442  -9.28123  1.000 24.07498 ? 280 ILE A HD13 1 
ATOM   1373 N N    . ARG A 1 101 ? -4.22955  18.26841  -10.78546 1.000 10.57070 ? 281 ARG A N    1 
ATOM   1374 C CA   . ARG A 1 101 ? -2.85670  18.70595  -10.55808 1.000 17.77205 ? 281 ARG A CA   1 
ATOM   1375 C C    . ARG A 1 101 ? -2.77468  20.22337  -10.48919 1.000 15.19900 ? 281 ARG A C    1 
ATOM   1376 O O    . ARG A 1 101 ? -2.03935  20.77613  -9.66320  1.000 15.64843 ? 281 ARG A O    1 
ATOM   1377 C CB   . ARG A 1 101 ? -1.94052  18.18044  -11.66274 1.000 23.50923 ? 281 ARG A CB   1 
ATOM   1378 C CG   . ARG A 1 101 ? -1.55957  16.72005  -11.52075 1.000 29.00220 ? 281 ARG A CG   1 
ATOM   1379 C CD   . ARG A 1 101 ? -0.44743  16.34836  -12.48988 1.000 25.35089 ? 281 ARG A CD   1 
ATOM   1380 N NE   . ARG A 1 101 ? -0.51020  14.94528  -12.87992 1.000 32.94760 ? 281 ARG A NE   1 
ATOM   1381 C CZ   . ARG A 1 101 ? -1.32414  14.45979  -13.80750 1.000 25.10744 ? 281 ARG A CZ   1 
ATOM   1382 N NH1  . ARG A 1 101 ? -2.15752  15.24115  -14.47488 1.000 21.45487 ? 281 ARG A NH1  1 
ATOM   1383 N NH2  . ARG A 1 101 ? -1.30217  13.15679  -14.07124 1.000 31.33192 ? 281 ARG A NH2  1 
ATOM   1384 H H    . ARG A 1 101 ? -4.34755  17.82170  -11.51080 1.000 13.13688 ? 281 ARG A H    1 
ATOM   1385 H HA   . ARG A 1 101 ? -2.55056  18.33927  -9.71385  1.000 21.77851 ? 281 ARG A HA   1 
ATOM   1386 H HB2  . ARG A 1 101 ? -2.39278  18.28390  -12.51460 1.000 28.66312 ? 281 ARG A HB2  1 
ATOM   1387 H HB3  . ARG A 1 101 ? -1.12082  18.69906  -11.65716 1.000 28.66312 ? 281 ARG A HB3  1 
ATOM   1388 H HG2  . ARG A 1 101 ? -1.24742  16.55406  -10.61747 1.000 35.25469 ? 281 ARG A HG2  1 
ATOM   1389 H HG3  . ARG A 1 101 ? -2.33154  16.16482  -11.71227 1.000 35.25469 ? 281 ARG A HG3  1 
ATOM   1390 H HD2  . ARG A 1 101 ? -0.52785  16.88948  -13.29089 1.000 30.87312 ? 281 ARG A HD2  1 
ATOM   1391 H HD3  . ARG A 1 101 ? 0.41094   16.50725  -12.06697 1.000 30.87312 ? 281 ARG A HD3  1 
ATOM   1392 H HE   . ARG A 1 101 ? 0.01660   14.39469  -12.48126 1.000 39.98916 ? 281 ARG A HE   1 
ATOM   1393 H HH11 . ARG A 1 101 ? -2.18000  16.08512  -14.31114 1.000 26.19789 ? 281 ARG A HH11 1 
ATOM   1394 H HH12 . ARG A 1 101 ? -2.67674  14.90508  -15.07242 1.000 26.19789 ? 281 ARG A HH12 1 
ATOM   1395 H HH21 . ARG A 1 101 ? -0.76469  12.64027  -13.64239 1.000 38.05036 ? 281 ARG A HH21 1 
ATOM   1396 H HH22 . ARG A 1 101 ? -1.82545  12.83053  -14.67068 1.000 38.05036 ? 281 ARG A HH22 1 
ATOM   1397 N N    . HIS A 1 102 ? -3.51212  20.91626  -11.35872 1.000 17.71558 ? 282 HIS A N    1 
ATOM   1398 C CA   . HIS A 1 102 ? -3.54903  22.37164  -11.28131 1.000 16.37336 ? 282 HIS A CA   1 
ATOM   1399 C C    . HIS A 1 102 ? -4.27359  22.87299  -10.03690 1.000 16.22347 ? 282 HIS A C    1 
ATOM   1400 O O    . HIS A 1 102 ? -4.16439  24.06233  -9.71699  1.000 15.87890 ? 282 HIS A O    1 
ATOM   1401 C CB   . HIS A 1 102 ? -4.20142  22.94787  -12.53871 1.000 20.30972 ? 282 HIS A CB   1 
ATOM   1402 C CG   . HIS A 1 102 ? -3.28089  23.00967  -13.71842 1.000 28.34636 ? 282 HIS A CG   1 
ATOM   1403 N ND1  . HIS A 1 102 ? -2.95092  21.89915  -14.46518 1.000 23.86976 ? 282 HIS A ND1  1 
ATOM   1404 C CD2  . HIS A 1 102 ? -2.61103  24.04773  -14.27289 1.000 23.99827 ? 282 HIS A CD2  1 
ATOM   1405 C CE1  . HIS A 1 102 ? -2.12365  22.25207  -15.43299 1.000 18.98931 ? 282 HIS A CE1  1 
ATOM   1406 N NE2  . HIS A 1 102 ? -1.90024  23.55025  -15.33774 1.000 17.67480 ? 282 HIS A NE2  1 
ATOM   1407 H H    . HIS A 1 102 ? -3.98810  20.57276  -11.98725 1.000 21.71074 ? 282 HIS A H    1 
ATOM   1408 H HA   . HIS A 1 102 ? -2.63919  22.70607  -11.24593 1.000 20.10008 ? 282 HIS A HA   1 
ATOM   1409 H HB2  . HIS A 1 102 ? -4.95760  22.39094  -12.78146 1.000 24.82371 ? 282 HIS A HB2  1 
ATOM   1410 H HB3  . HIS A 1 102 ? -4.50157  23.85058  -12.34916 1.000 24.82371 ? 282 HIS A HB3  1 
ATOM   1411 H HD1  . HIS A 1 102 ? -3.23858  21.10119  -14.32332 1.000 29.09576 ? 282 HIS A HD1  1 
ATOM   1412 H HD2  . HIS A 1 102 ? -2.62891  24.93227  -13.98624 1.000 29.24997 ? 282 HIS A HD2  1 
ATOM   1413 H HE1  . HIS A 1 102 ? -1.76037  21.68304  -16.07263 1.000 23.23921 ? 282 HIS A HE1  1 
ATOM   1414 N N    . CYS A 1 103 ? -5.00295  22.00639  -9.33186  1.000 29.25495 ? 283 CYS A N    1 
ATOM   1415 C CA   . CYS A 1 103 ? -5.60977  22.36106  -8.05303  1.000 14.48355 ? 283 CYS A CA   1 
ATOM   1416 C C    . CYS A 1 103 ? -4.74148  21.97878  -6.85370  1.000 26.38388 ? 283 CYS A C    1 
ATOM   1417 O O    . CYS A 1 103 ? -5.23840  21.97066  -5.72194  1.000 22.67974 ? 283 CYS A O    1 
ATOM   1418 C CB   . CYS A 1 103 ? -6.98352  21.69936  -7.91229  1.000 17.64057 ? 283 CYS A CB   1 
ATOM   1419 S SG   . CYS A 1 103 ? -8.22689  22.25370  -9.08971  1.000 29.68030 ? 283 CYS A SG   1 
ATOM   1420 H H    . CYS A 1 103 ? -5.16096  21.19785  -9.57863  1.000 35.55799 ? 283 CYS A H    1 
ATOM   1421 H HA   . CYS A 1 103 ? -5.73479  23.32288  -8.03986  1.000 17.83231 ? 283 CYS A HA   1 
ATOM   1422 H HB2  . CYS A 1 103 ? -6.87615  20.74289  -8.03289  1.000 21.62073 ? 283 CYS A HB2  1 
ATOM   1423 H HB3  . CYS A 1 103 ? -7.32308  21.88556  -7.02295  1.000 21.62073 ? 283 CYS A HB3  1 
ATOM   1424 H HG   . CYS A 1 103 ? -7.84204  22.02197  -10.20245 1.000 36.06841 ? 283 CYS A HG   1 
ATOM   1425 N N    . ASN A 1 104 ? -3.46421  21.67268  -7.07112  1.000 37.74607 ? 284 ASN A N    1 
ATOM   1426 C CA   . ASN A 1 104 ? -2.61834  21.15504  -6.00131  1.000 31.16706 ? 284 ASN A CA   1 
ATOM   1427 C C    . ASN A 1 104 ? -2.57083  22.11817  -4.82062  1.000 18.98435 ? 284 ASN A C    1 
ATOM   1428 O O    . ASN A 1 104 ? -2.16246  23.27491  -4.96317  1.000 21.26270 ? 284 ASN A O    1 
ATOM   1429 C CB   . ASN A 1 104 ? -1.20814  20.90030  -6.53318  1.000 42.55241 ? 284 ASN A CB   1 
ATOM   1430 H H    . ASN A 1 104 ? -3.06461  21.75568  -7.82811  1.000 45.74734 ? 284 ASN A H    1 
ATOM   1431 H HA   . ASN A 1 104 ? -2.99198  20.31670  -5.68751  1.000 37.85252 ? 284 ASN A HA   1 
ATOM   1432 N N    . GLY A 1 105 ? -2.98420  21.63266  -3.65147  1.000 25.15756 ? 285 GLY A N    1 
ATOM   1433 C CA   . GLY A 1 105 ? -2.88308  22.39535  -2.42457  1.000 20.11328 ? 285 GLY A CA   1 
ATOM   1434 C C    . GLY A 1 105 ? -3.90901  23.49051  -2.25018  1.000 29.43023 ? 285 GLY A C    1 
ATOM   1435 O O    . GLY A 1 105 ? -3.75097  24.32337  -1.35000  1.000 31.22054 ? 285 GLY A O    1 
ATOM   1436 H H    . GLY A 1 105 ? -3.33084  20.85252  -3.54746  1.000 30.64113 ? 285 GLY A H    1 
ATOM   1437 H HA2  . GLY A 1 105 ? -2.97504  21.78624  -1.67528  1.000 24.58798 ? 285 GLY A HA2  1 
ATOM   1438 H HA3  . GLY A 1 105 ? -2.00589  22.80798  -2.39031  1.000 24.58798 ? 285 GLY A HA3  1 
ATOM   1439 N N    . LYS A 1 106 ? -4.95408  23.52130  -3.07746  1.000 18.67366 ? 286 LYS A N    1 
ATOM   1440 C CA   . LYS A 1 106 ? -5.99289  24.53390  -2.97989  1.000 14.84113 ? 286 LYS A CA   1 
ATOM   1441 C C    . LYS A 1 106 ? -7.36969  23.96786  -2.66727  1.000 23.93756 ? 286 LYS A C    1 
ATOM   1442 O O    . LYS A 1 106 ? -8.28361  24.74645  -2.37166  1.000 21.78150 ? 286 LYS A O    1 
ATOM   1443 C CB   . LYS A 1 106 ? -6.07463  25.34137  -4.28537  1.000 16.57829 ? 286 LYS A CB   1 
ATOM   1444 C CG   . LYS A 1 106 ? -4.76242  25.99927  -4.69629  1.000 29.88373 ? 286 LYS A CG   1 
ATOM   1445 C CD   . LYS A 1 106 ? -4.35173  27.10370  -3.73076  1.000 28.41952 ? 286 LYS A CD   1 
ATOM   1446 C CE   . LYS A 1 106 ? -5.25150  28.32449  -3.85577  1.000 36.67324 ? 286 LYS A CE   1 
ATOM   1447 N NZ   . LYS A 1 106 ? -4.47185  29.59327  -3.83135  1.000 33.60904 ? 286 LYS A NZ   1 
ATOM   1448 H H    . LYS A 1 106 ? -5.08181  22.95534  -3.71226  1.000 22.86044 ? 286 LYS A H    1 
ATOM   1449 H HA   . LYS A 1 106 ? -5.75818  25.14709  -2.26589  1.000 15.91072 ? 286 LYS A HA   1 
ATOM   1450 H HB2  . LYS A 1 106 ? -6.34217  24.74537  -5.00238  1.000 20.34600 ? 286 LYS A HB2  1 
ATOM   1451 H HB3  . LYS A 1 106 ? -6.73407  26.04405  -4.17458  1.000 20.34600 ? 286 LYS A HB3  1 
ATOM   1452 H HG2  . LYS A 1 106 ? -4.05977  25.33066  -4.70822  1.000 36.31253 ? 286 LYS A HG2  1 
ATOM   1453 H HG3  . LYS A 1 106 ? -4.86343  26.39015  -5.57828  1.000 36.31253 ? 286 LYS A HG3  1 
ATOM   1454 H HD2  . LYS A 1 106 ? -4.41286  26.77301  -2.82092  1.000 34.55547 ? 286 LYS A HD2  1 
ATOM   1455 H HD3  . LYS A 1 106 ? -3.44113  27.37623  -3.92423  1.000 34.55547 ? 286 LYS A HD3  1 
ATOM   1456 H HE2  . LYS A 1 106 ? -5.73429  28.28111  -4.69597  1.000 44.45993 ? 286 LYS A HE2  1 
ATOM   1457 H HE3  . LYS A 1 106 ? -5.87667  28.33815  -3.11424  1.000 44.45993 ? 286 LYS A HE3  1 
ATOM   1458 H HZ1  . LYS A 1 106 ? -5.02090  30.28947  -3.90843  1.000 40.78290 ? 286 LYS A HZ1  1 
ATOM   1459 H HZ2  . LYS A 1 106 ? -4.02505  29.66128  -3.06464  1.000 40.78290 ? 286 LYS A HZ2  1 
ATOM   1460 H HZ3  . LYS A 1 106 ? -3.89155  29.60699  -4.50601  1.000 40.78290 ? 286 LYS A HZ3  1 
ATOM   1461 N N    . LEU A 1 107 ? -7.54883  22.65075  -2.72623  1.000 25.25887 ? 287 LEU A N    1 
ATOM   1462 C CA   . LEU A 1 107 ? -8.82774  22.01759  -2.41151  1.000 23.03072 ? 287 LEU A CA   1 
ATOM   1463 C C    . LEU A 1 107 ? -8.80285  21.61763  -0.94175  1.000 16.27891 ? 287 LEU A C    1 
ATOM   1464 O O    . LEU A 1 107 ? -8.24548  20.57996  -0.57768  1.000 20.45855 ? 287 LEU A O    1 
ATOM   1465 C CB   . LEU A 1 107 ? -9.06706  20.81848  -3.32105  1.000 15.82093 ? 287 LEU A CB   1 
ATOM   1466 C CG   . LEU A 1 107 ? -9.25486  21.15863  -4.80179  1.000 24.26425 ? 287 LEU A CG   1 
ATOM   1467 C CD1  . LEU A 1 107 ? -9.32960  19.89384  -5.63935  1.000 20.95683 ? 287 LEU A CD1  1 
ATOM   1468 C CD2  . LEU A 1 107 ? -10.49996 22.01074  -5.00768  1.000 23.39154 ? 287 LEU A CD2  1 
ATOM   1469 H H    . LEU A 1 107 ? -6.93411  22.09244  -2.94986  1.000 30.76270 ? 287 LEU A H    1 
ATOM   1470 H HA   . LEU A 1 107 ? -9.55084  22.65006  -2.54576  1.000 28.08891 ? 287 LEU A HA   1 
ATOM   1471 H HB2  . LEU A 1 107 ? -8.30313  20.22464  -3.25275  1.000 16.72487 ? 287 LEU A HB2  1 
ATOM   1472 H HB3  . LEU A 1 107 ? -9.86945  20.36253  -3.02242  1.000 16.72487 ? 287 LEU A HB3  1 
ATOM   1473 H HG   . LEU A 1 107 ? -8.48835  21.67203  -5.10143  1.000 29.56915 ? 287 LEU A HG   1 
ATOM   1474 H HD11 . LEU A 1 107 ? -9.44530  20.13832  -6.57088  1.000 25.60025 ? 287 LEU A HD11 1 
ATOM   1475 H HD12 . LEU A 1 107 ? -8.50650  19.39268  -5.52867  1.000 25.60025 ? 287 LEU A HD12 1 
ATOM   1476 H HD13 . LEU A 1 107 ? -10.08362 19.36157  -5.34096  1.000 25.60025 ? 287 LEU A HD13 1 
ATOM   1477 H HD21 . LEU A 1 107 ? -10.68505 22.07509  -5.95768  1.000 28.52190 ? 287 LEU A HD21 1 
ATOM   1478 H HD22 . LEU A 1 107 ? -11.24760 21.59259  -4.55261  1.000 28.52190 ? 287 LEU A HD22 1 
ATOM   1479 H HD23 . LEU A 1 107 ? -10.34190 22.89468  -4.64086  1.000 28.52190 ? 287 LEU A HD23 1 
ATOM   1480 N N    . GLY A 1 108 ? -9.40353  22.44732  -0.09192  1.000 17.09371 ? 288 GLY A N    1 
ATOM   1481 C CA   . GLY A 1 108 ? -9.38232  22.16862  1.33319   1.000 22.59484 ? 288 GLY A CA   1 
ATOM   1482 C C    . GLY A 1 108 ? -7.96083  22.06188  1.84474   1.000 26.85956 ? 288 GLY A C    1 
ATOM   1483 O O    . GLY A 1 108 ? -7.05362  22.76931  1.39248   1.000 29.70513 ? 288 GLY A O    1 
ATOM   1484 H H    . GLY A 1 108 ? -9.82219  23.16511  -0.31352  1.000 18.25221 ? 288 GLY A H    1 
ATOM   1485 H HA2  . GLY A 1 108 ? -9.83273  22.88176  1.81222   1.000 27.56585 ? 288 GLY A HA2  1 
ATOM   1486 H HA3  . GLY A 1 108 ? -9.84007  21.33173  1.50920   1.000 27.56585 ? 288 GLY A HA3  1 
ATOM   1487 N N    . SER A 1 109 ? -7.75901  21.16313  2.80599   1.000 23.70259 ? 289 SER A N    1 
ATOM   1488 C CA   . SER A 1 109 ? -6.43461  20.84176  3.31785   1.000 30.10087 ? 289 SER A CA   1 
ATOM   1489 C C    . SER A 1 109 ? -5.85771  19.58947  2.67103   1.000 32.95723 ? 289 SER A C    1 
ATOM   1490 O O    . SER A 1 109 ? -4.80088  19.11171  3.09636   1.000 28.72620 ? 289 SER A O    1 
ATOM   1491 C CB   . SER A 1 109 ? -6.48553  20.66650  4.83692   1.000 35.76963 ? 289 SER A CB   1 
ATOM   1492 O OG   . SER A 1 109 ? -7.36418  19.61510  5.19889   1.000 43.16851 ? 289 SER A OG   1 
ATOM   1493 H H    . SER A 1 109 ? -8.38985  20.71763  3.18435   1.000 28.89516 ? 289 SER A H    1 
ATOM   1494 H HA   . SER A 1 109 ? -5.83848  21.58234  3.12531   1.000 36.57309 ? 289 SER A HA   1 
ATOM   1495 H HB2  . SER A 1 109 ? -5.59497  20.45795  5.15990   1.000 43.37561 ? 289 SER A HB2  1 
ATOM   1496 H HB3  . SER A 1 109 ? -6.79940  21.49165  5.23880   1.000 43.37561 ? 289 SER A HB3  1 
ATOM   1497 H HG   . SER A 1 109 ? -7.37819  19.52711  6.03415   1.000 52.25426 ? 289 SER A HG   1 
ATOM   1498 N N    . TYR A 1 110 ? -6.52714  19.05232  1.65516   1.000 28.45455 ? 290 TYR A N    1 
ATOM   1499 C CA   . TYR A 1 110 ? -6.12100  17.78791  1.06227   1.000 20.46061 ? 290 TYR A CA   1 
ATOM   1500 C C    . TYR A 1 110 ? -4.80539  17.92719  0.30525   1.000 22.89444 ? 290 TYR A C    1 
ATOM   1501 O O    . TYR A 1 110 ? -4.47532  18.98790  -0.23266  1.000 14.30103 ? 290 TYR A O    1 
ATOM   1502 C CB   . TYR A 1 110 ? -7.20571  17.27562  0.11445   1.000 14.69853 ? 290 TYR A CB   1 
ATOM   1503 C CG   . TYR A 1 110 ? -8.52290  16.98340  0.79291   1.000 15.75191 ? 290 TYR A CG   1 
ATOM   1504 C CD1  . TYR A 1 110 ? -8.60201  16.06768  1.83427   1.000 28.50728 ? 290 TYR A CD1  1 
ATOM   1505 C CD2  . TYR A 1 110 ? -9.68823  17.62194  0.39259   1.000 17.95673 ? 290 TYR A CD2  1 
ATOM   1506 C CE1  . TYR A 1 110 ? -9.80450  15.79788  2.45733   1.000 23.47907 ? 290 TYR A CE1  1 
ATOM   1507 C CE2  . TYR A 1 110 ? -10.89497 17.35810  1.00892   1.000 18.25289 ? 290 TYR A CE2  1 
ATOM   1508 C CZ   . TYR A 1 110 ? -10.94731 16.44706  2.04051   1.000 20.63847 ? 290 TYR A CZ   1 
ATOM   1509 O OH   . TYR A 1 110 ? -12.14780 16.18386  2.65576   1.000 26.65661 ? 290 TYR A OH   1 
ATOM   1510 H H    . TYR A 1 110 ? -7.22268  19.40310  1.29076   1.000 34.59751 ? 290 TYR A H    1 
ATOM   1511 H HA   . TYR A 1 110 ? -5.99140  17.13644  1.76916   1.000 25.00478 ? 290 TYR A HA   1 
ATOM   1512 H HB2  . TYR A 1 110 ? -7.36672  17.94740  -0.56650  1.000 15.37799 ? 290 TYR A HB2  1 
ATOM   1513 H HB3  . TYR A 1 110 ? -6.89654  16.45348  -0.29714  1.000 15.37799 ? 290 TYR A HB3  1 
ATOM   1514 H HD1  . TYR A 1 110 ? -7.83221  15.62887  2.11667   1.000 34.66078 ? 290 TYR A HD1  1 
ATOM   1515 H HD2  . TYR A 1 110 ? -9.65561  18.23834  -0.30302  1.000 22.00013 ? 290 TYR A HD2  1 
ATOM   1516 H HE1  . TYR A 1 110 ? -9.84327  15.18240  3.15345   1.000 28.62694 ? 290 TYR A HE1  1 
ATOM   1517 H HE2  . TYR A 1 110 ? -11.66799 17.79295  0.72921   1.000 22.35552 ? 290 TYR A HE2  1 
ATOM   1518 H HH   . TYR A 1 110 ? -12.04222 15.60628  3.25648   1.000 32.43998 ? 290 TYR A HH   1 
ATOM   1519 N N    . LYS A 1 111 ? -4.04999  16.83255  0.27353   0.960 13.62822 ? 291 LYS A N    1 
ATOM   1520 C CA   . LYS A 1 111 ? -2.84300  16.70784  -0.54094  0.960 20.81482 ? 291 LYS A CA   1 
ATOM   1521 C C    . LYS A 1 111 ? -3.07485  15.52189  -1.47245  0.960 21.69352 ? 291 LYS A C    1 
ATOM   1522 O O    . LYS A 1 111 ? -2.84997  14.36947  -1.08907  0.960 19.22139 ? 291 LYS A O    1 
ATOM   1523 C CB   . LYS A 1 111 ? -1.60412  16.51844  0.32931   0.960 26.28811 ? 291 LYS A CB   1 
ATOM   1524 C CG   . LYS A 1 111 ? -0.29862  16.48479  -0.44984  0.960 24.62681 ? 291 LYS A CG   1 
ATOM   1525 C CD   . LYS A 1 111 ? 0.88442   16.84483  0.43789   0.960 33.64983 ? 291 LYS A CD   1 
ATOM   1526 C CE   . LYS A 1 111 ? 0.96443   15.94893  1.66336   0.960 33.01064 ? 291 LYS A CE   1 
ATOM   1527 N NZ   . LYS A 1 111 ? 2.30546   16.01323  2.31251   0.960 30.33382 ? 291 LYS A NZ   1 
ATOM   1528 H H    . LYS A 1 111 ? -4.22206  16.12481  0.73080   0.960 16.80591 ? 291 LYS A H    1 
ATOM   1529 H HA   . LYS A 1 111 ? -2.70548  17.50939  -1.06962  0.960 25.42983 ? 291 LYS A HA   1 
ATOM   1530 H HB2  . LYS A 1 111 ? -1.55221  17.25353  0.96006   0.960 31.99779 ? 291 LYS A HB2  1 
ATOM   1531 H HB3  . LYS A 1 111 ? -1.68486  15.67744  0.80587   0.960 31.99779 ? 291 LYS A HB3  1 
ATOM   1532 H HG2  . LYS A 1 111 ? -0.15637  15.59207  -0.80159  0.960 30.00423 ? 291 LYS A HG2  1 
ATOM   1533 H HG3  . LYS A 1 111 ? -0.34105  17.12511  -1.17723  0.960 30.00423 ? 291 LYS A HG3  1 
ATOM   1534 H HD2  . LYS A 1 111 ? 1.70630   16.74256  -0.06703  0.960 40.83185 ? 291 LYS A HD2  1 
ATOM   1535 H HD3  . LYS A 1 111 ? 0.79161   17.76245  0.73830   0.960 40.83185 ? 291 LYS A HD3  1 
ATOM   1536 H HE2  . LYS A 1 111 ? 0.30010   16.23271  2.31069   0.960 40.06482 ? 291 LYS A HE2  1 
ATOM   1537 H HE3  . LYS A 1 111 ? 0.79901   15.03038  1.39914   0.960 40.06482 ? 291 LYS A HE3  1 
ATOM   1538 H HZ1  . LYS A 1 111 ? 2.47985   16.84747  2.56890   0.960 36.85263 ? 291 LYS A HZ1  1 
ATOM   1539 H HZ2  . LYS A 1 111 ? 2.32395   15.48187  3.02624   0.960 36.85263 ? 291 LYS A HZ2  1 
ATOM   1540 H HZ3  . LYS A 1 111 ? 2.93378   15.74974  1.73990   0.960 36.85263 ? 291 LYS A HZ3  1 
ATOM   1541 N N    . ILE A 1 112 ? -3.53272  15.80298  -2.68843  1.000 17.70812 ? 292 ILE A N    1 
ATOM   1542 C CA   . ILE A 1 112 ? -3.97569  14.76576  -3.61331  1.000 12.88883 ? 292 ILE A CA   1 
ATOM   1543 C C    . ILE A 1 112 ? -2.77172  14.25976  -4.39652  1.000 21.81924 ? 292 ILE A C    1 
ATOM   1544 O O    . ILE A 1 112 ? -2.07607  15.03773  -5.05841  1.000 25.47566 ? 292 ILE A O    1 
ATOM   1545 C CB   . ILE A 1 112 ? -5.06989  15.29289  -4.55363  1.000 23.51934 ? 292 ILE A CB   1 
ATOM   1546 C CG1  . ILE A 1 112 ? -6.27051  15.77925  -3.73545  1.000 18.35477 ? 292 ILE A CG1  1 
ATOM   1547 C CG2  . ILE A 1 112 ? -5.49880  14.20642  -5.53223  1.000 26.05931 ? 292 ILE A CG2  1 
ATOM   1548 C CD1  . ILE A 1 112 ? -7.33836  16.47630  -4.55248  1.000 24.91350 ? 292 ILE A CD1  1 
ATOM   1549 H H    . ILE A 1 112 ? -3.59737  16.59974  -3.00560  1.000 21.70180 ? 292 ILE A H    1 
ATOM   1550 H HA   . ILE A 1 112 ? -4.33793  14.02178  -3.10717  1.000 15.91865 ? 292 ILE A HA   1 
ATOM   1551 H HB   . ILE A 1 112 ? -4.71173  16.03862  -5.06009  1.000 28.67526 ? 292 ILE A HB   1 
ATOM   1552 H HG12 . ILE A 1 112 ? -6.68260  15.01403  -3.30474  1.000 22.47778 ? 292 ILE A HG12 1 
ATOM   1553 H HG13 . ILE A 1 112 ? -5.95581  16.40698  -3.06626  1.000 22.47778 ? 292 ILE A HG13 1 
ATOM   1554 H HG21 . ILE A 1 112 ? -6.25217  14.52856  -6.05143  1.000 31.72322 ? 292 ILE A HG21 1 
ATOM   1555 H HG22 . ILE A 1 112 ? -4.75571  14.00004  -6.12055  1.000 31.72322 ? 292 ILE A HG22 1 
ATOM   1556 H HG23 . ILE A 1 112 ? -5.75520  13.41518  -5.03314  1.000 31.72322 ? 292 ILE A HG23 1 
ATOM   1557 H HD11 . ILE A 1 112 ? -7.96014  16.91498  -3.95094  1.000 30.34824 ? 292 ILE A HD11 1 
ATOM   1558 H HD12 . ILE A 1 112 ? -6.91676  17.13278  -5.12883  1.000 30.34824 ? 292 ILE A HD12 1 
ATOM   1559 H HD13 . ILE A 1 112 ? -7.80619  15.81717  -5.08875  1.000 30.34824 ? 292 ILE A HD13 1 
ATOM   1560 N N    . ASN A 1 113 ? -2.53105  12.94878  -4.32404  1.000 27.86657 ? 293 ASN A N    1 
ATOM   1561 C CA   . ASN A 1 113 ? -1.39664  12.32601  -4.98734  1.000 25.32387 ? 293 ASN A CA   1 
ATOM   1562 C C    . ASN A 1 113 ? -1.78302  11.14698  -5.86976  1.000 23.44424 ? 293 ASN A C    1 
ATOM   1563 O O    . ASN A 1 113 ? -0.90776  10.58616  -6.53828  1.000 21.21208 ? 293 ASN A O    1 
ATOM   1564 C CB   . ASN A 1 113 ? -0.36952  11.85303  -3.94687  1.000 21.62455 ? 293 ASN A CB   1 
ATOM   1565 C CG   . ASN A 1 113 ? -0.89863  10.72848  -3.07587  1.000 35.49464 ? 293 ASN A CG   1 
ATOM   1566 O OD1  . ASN A 1 113 ? -2.10822  10.51497  -2.98275  1.000 29.29455 ? 293 ASN A OD1  1 
ATOM   1567 N ND2  . ASN A 1 113 ? 0.00790   10.00153  -2.43335  1.000 43.01213 ? 293 ASN A ND2  1 
ATOM   1568 H H    . ASN A 1 113 ? -3.02189  12.39343  -3.88786  1.000 33.89193 ? 293 ASN A H    1 
ATOM   1569 H HA   . ASN A 1 113 ? -0.96988  12.98896  -5.55238  1.000 30.84069 ? 293 ASN A HA   1 
ATOM   1570 H HB2  . ASN A 1 113 ? 0.42162   11.53079  -4.40639  1.000 26.40151 ? 293 ASN A HB2  1 
ATOM   1571 H HB3  . ASN A 1 113 ? -0.13777  12.59716  -3.36941  1.000 26.40151 ? 293 ASN A HB3  1 
ATOM   1572 H HD21 . ASN A 1 113 ? -0.24147  9.35256   -1.92714  1.000 52.06661 ? 293 ASN A HD21 1 
ATOM   1573 H HD22 . ASN A 1 113 ? 0.84441   10.17967  -2.52341  1.000 52.06661 ? 293 ASN A HD22 1 
ATOM   1574 N N    . GLY A 1 114 ? -3.05240  10.75781  -5.89769  1.000 17.30009 ? 294 GLY A N    1 
ATOM   1575 C CA   . GLY A 1 114 ? -3.44834  9.59684   -6.67179  1.000 28.53969 ? 294 GLY A CA   1 
ATOM   1576 C C    . GLY A 1 114 ? -4.95334  9.50596   -6.77652  1.000 19.48457 ? 294 GLY A C    1 
ATOM   1577 O O    . GLY A 1 114 ? -5.69173  10.31450  -6.20717  1.000 16.35243 ? 294 GLY A O    1 
ATOM   1578 H H    A GLY A 1 114 ? -3.69553  11.14712  -5.48005  0.500 21.21216 ? 294 GLY A H    1 
ATOM   1579 H H    B GLY A 1 114 ? -3.69553  11.14712  -5.48005  0.500 21.21216 ? 294 GLY A H    1 
ATOM   1580 H HA2  . GLY A 1 114 ? -3.07709  9.65742   -7.56588  1.000 34.69968 ? 294 GLY A HA2  1 
ATOM   1581 H HA3  . GLY A 1 114 ? -3.11661  8.79087   -6.24603  1.000 34.69968 ? 294 GLY A HA3  1 
ATOM   1582 N N    . ARG A 1 115 ? -5.39933  8.49454   -7.51967  1.000 12.62630 ? 295 ARG A N    1 
ATOM   1583 C CA   . ARG A 1 115 ? -6.81788  8.27902   -7.75716  1.000 13.04856 ? 295 ARG A CA   1 
ATOM   1584 C C    . ARG A 1 115 ? -7.05824  6.80638   -8.05003  1.000 14.21780 ? 295 ARG A C    1 
ATOM   1585 O O    . ARG A 1 115 ? -6.12800  6.04977   -8.34076  1.000 18.21492 ? 295 ARG A O    1 
ATOM   1586 C CB   . ARG A 1 115 ? -7.33205  9.12540   -8.92752  1.000 12.86567 ? 295 ARG A CB   1 
ATOM   1587 C CG   . ARG A 1 115 ? -6.52577  8.95965   -10.20926 1.000 13.92052 ? 295 ARG A CG   1 
ATOM   1588 C CD   . ARG A 1 115 ? -7.37674  9.23788   -11.43707 1.000 19.49715 ? 295 ARG A CD   1 
ATOM   1589 N NE   . ARG A 1 115 ? -6.61119  9.17539   -12.67593 1.000 13.39880 ? 295 ARG A NE   1 
ATOM   1590 C CZ   . ARG A 1 115 ? -6.28039  8.05200   -13.29813 1.000 21.03102 ? 295 ARG A CZ   1 
ATOM   1591 N NH1  . ARG A 1 115 ? -6.62639  6.86726   -12.81942 1.000 18.55093 ? 295 ARG A NH1  1 
ATOM   1592 N NH2  . ARG A 1 115 ? -5.58264  8.11859   -14.42805 1.000 26.57222 ? 295 ARG A NH2  1 
ATOM   1593 H H    . ARG A 1 115 ? -4.89146  7.91425   -7.90038  1.000 15.60360 ? 295 ARG A H    1 
ATOM   1594 H HA   . ARG A 1 115 ? -7.30800  8.52185   -6.95610  1.000 16.11032 ? 295 ARG A HA   1 
ATOM   1595 H HB2  . ARG A 1 115 ? -8.24763  8.86851   -9.11889  1.000 15.06263 ? 295 ARG A HB2  1 
ATOM   1596 H HB3  . ARG A 1 115 ? -7.29600  10.06112  -8.67449  1.000 15.06263 ? 295 ARG A HB3  1 
ATOM   1597 H HG2  . ARG A 1 115 ? -5.78247  9.58286   -10.20496 1.000 17.15667 ? 295 ARG A HG2  1 
ATOM   1598 H HG3  . ARG A 1 115 ? -6.19526  8.04948   -10.26634 1.000 17.15667 ? 295 ARG A HG3  1 
ATOM   1599 H HD2  . ARG A 1 115 ? -8.08493  8.57700   -11.48804 1.000 23.84863 ? 295 ARG A HD2  1 
ATOM   1600 H HD3  . ARG A 1 115 ? -7.75738  10.12706  -11.36381 1.000 23.84863 ? 295 ARG A HD3  1 
ATOM   1601 H HE   . ARG A 1 115 ? -6.35663  9.91787   -13.02739 1.000 16.53061 ? 295 ARG A HE   1 
ATOM   1602 H HH11 . ARG A 1 115 ? -7.07633  6.81353   -12.08848 1.000 22.71316 ? 295 ARG A HH11 1 
ATOM   1603 H HH12 . ARG A 1 115 ? -6.40123  6.15134   -13.23937 1.000 22.71316 ? 295 ARG A HH12 1 
ATOM   1604 H HH21 . ARG A 1 115 ? -5.35170  8.88340   -14.74638 1.000 32.33871 ? 295 ARG A HH21 1 
ATOM   1605 H HH22 . ARG A 1 115 ? -5.36228  7.39685   -14.84052 1.000 32.33871 ? 295 ARG A HH22 1 
ATOM   1606 N N    . THR A 1 116 ? -8.32580  6.40972   -7.97155  1.000 14.93565 ? 296 THR A N    1 
ATOM   1607 C CA   . THR A 1 116 ? -8.72653  5.08478   -8.41317  1.000 16.85791 ? 296 THR A CA   1 
ATOM   1608 C C    . THR A 1 116 ? -8.66715  4.99753   -9.93725  1.000 15.01867 ? 296 THR A C    1 
ATOM   1609 O O    . THR A 1 116 ? -8.43300  5.98614   -10.63837 1.000 14.92699 ? 296 THR A O    1 
ATOM   1610 C CB   . THR A 1 116 ? -10.14579 4.76009   -7.94393  1.000 15.32018 ? 296 THR A CB   1 
ATOM   1611 O OG1  . THR A 1 116 ? -11.07204 5.67028   -8.55078  1.000 16.85702 ? 296 THR A OG1  1 
ATOM   1612 C CG2  . THR A 1 116 ? -10.25977 4.85831   -6.43333  1.000 16.11220 ? 296 THR A CG2  1 
ATOM   1613 H H    . THR A 1 116 ? -8.97001  6.89073   -7.66623  1.000 18.37482 ? 296 THR A H    1 
ATOM   1614 H HA   . THR A 1 116 ? -8.11931  4.43174   -8.03144  1.000 20.68154 ? 296 THR A HA   1 
ATOM   1615 H HB   . THR A 1 116 ? -10.36472 3.85087   -8.20141  1.000 16.62694 ? 296 THR A HB   1 
ATOM   1616 H HG1  . THR A 1 116 ? -11.09990 5.54128   -9.38034  1.000 20.68048 ? 296 THR A HG1  1 
ATOM   1617 H HG21 . THR A 1 116 ? -11.17637 4.69914   -6.15874  1.000 19.78669 ? 296 THR A HG21 1 
ATOM   1618 H HG22 . THR A 1 116 ? -9.68627  4.19805   -6.01373  1.000 19.78669 ? 296 THR A HG22 1 
ATOM   1619 H HG23 . THR A 1 116 ? -9.99138  5.74213   -6.13715  1.000 19.78669 ? 296 THR A HG23 1 
ATOM   1620 N N    . LYS A 1 117 ? -8.88302  3.78973   -10.45182 1.000 18.05947 ? 297 LYS A N    1 
ATOM   1621 C CA   . LYS A 1 117 ? -9.14217  3.63925   -11.87284 1.000 20.12395 ? 297 LYS A CA   1 
ATOM   1622 C C    . LYS A 1 117 ? -10.50572 4.24158   -12.20563 1.000 23.32121 ? 297 LYS A C    1 
ATOM   1623 O O    . LYS A 1 117 ? -11.28069 4.61951   -11.32185 1.000 15.98687 ? 297 LYS A O    1 
ATOM   1624 C CB   . LYS A 1 117 ? -9.09483  2.16820   -12.28211 1.000 25.80888 ? 297 LYS A CB   1 
ATOM   1625 C CG   . LYS A 1 117 ? -7.72152  1.52888   -12.16955 1.000 18.09715 ? 297 LYS A CG   1 
ATOM   1626 C CD   . LYS A 1 117 ? -7.75840  0.07397   -12.61399 1.000 15.90620 ? 297 LYS A CD   1 
ATOM   1627 C CE   . LYS A 1 117 ? -6.44083  -0.62904  -12.34027 1.000 35.93125 ? 297 LYS A CE   1 
ATOM   1628 N NZ   . LYS A 1 117 ? -6.53349  -2.09360  -12.59501 1.000 42.55303 ? 297 LYS A NZ   1 
ATOM   1629 H H    . LYS A 1 117 ? -8.88402  3.05563   -10.00382 1.000 22.12342 ? 297 LYS A H    1 
ATOM   1630 H HA   . LYS A 1 117 ? -8.45887  4.10407   -12.38072 1.000 24.60079 ? 297 LYS A HA   1 
ATOM   1631 H HB2  . LYS A 1 117 ? -9.69867  1.66863   -11.71052 1.000 31.42270 ? 297 LYS A HB2  1 
ATOM   1632 H HB3  . LYS A 1 117 ? -9.37734  2.09537   -13.20720 1.000 31.42270 ? 297 LYS A HB3  1 
ATOM   1633 H HG2  . LYS A 1 117 ? -7.09527  2.00681   -12.73550 1.000 22.16862 ? 297 LYS A HG2  1 
ATOM   1634 H HG3  . LYS A 1 117 ? -7.42517  1.56031   -11.24647 1.000 22.16862 ? 297 LYS A HG3  1 
ATOM   1635 H HD2  . LYS A 1 117 ? -8.45801  -0.39170  -12.12964 1.000 19.53948 ? 297 LYS A HD2  1 
ATOM   1636 H HD3  . LYS A 1 117 ? -7.93207  0.03420   -13.56749 1.000 19.53948 ? 297 LYS A HD3  1 
ATOM   1637 H HE2  . LYS A 1 117 ? -5.75560  -0.26227  -12.92067 1.000 43.56954 ? 297 LYS A HE2  1 
ATOM   1638 H HE3  . LYS A 1 117 ? -6.19439  -0.49702  -11.41144 1.000 43.56954 ? 297 LYS A HE3  1 
ATOM   1639 H HZ1  . LYS A 1 117 ? -6.75358  -2.24147  -13.44460 1.000 51.51569 ? 297 LYS A HZ1  1 
ATOM   1640 H HZ2  . LYS A 1 117 ? -5.75028  -2.48182  -12.42776 1.000 51.51569 ? 297 LYS A HZ2  1 
ATOM   1641 H HZ3  . LYS A 1 117 ? -7.15343  -2.45546  -12.06886 1.000 51.51569 ? 297 LYS A HZ3  1 
ATOM   1642 N N    . ALA A 1 118 ? -10.80003 4.33516   -13.49926 1.000 18.15994 ? 298 ALA A N    1 
ATOM   1643 C CA   . ALA A 1 118 ? -12.06132 4.92069   -13.93617 1.000 16.58703 ? 298 ALA A CA   1 
ATOM   1644 C C    . ALA A 1 118 ? -13.15995 3.86687   -13.87847 1.000 26.39694 ? 298 ALA A C    1 
ATOM   1645 O O    . ALA A 1 118 ? -13.03301 2.79757   -14.48033 1.000 26.65311 ? 298 ALA A O    1 
ATOM   1646 C CB   . ALA A 1 118 ? -11.92926 5.48596   -15.34787 1.000 16.49461 ? 298 ALA A CB   1 
ATOM   1647 H H    . ALA A 1 118 ? -10.28927 4.06860   -14.13775 1.000 22.24398 ? 298 ALA A H    1 
ATOM   1648 H HA   . ALA A 1 118 ? -12.30004 5.64803   -13.34044 1.000 17.64419 ? 298 ALA A HA   1 
ATOM   1649 H HB1  . ALA A 1 118 ? -12.79576 5.80848   -15.64125 1.000 19.76626 ? 298 ALA A HB1  1 
ATOM   1650 H HB2  . ALA A 1 118 ? -11.29080 6.21614   -15.33723 1.000 19.76626 ? 298 ALA A HB2  1 
ATOM   1651 H HB3  . ALA A 1 118 ? -11.61926 4.78413   -15.94136 1.000 19.76626 ? 298 ALA A HB3  1 
ATOM   1652 N N    . MET A 1 119 ? -14.23407 4.16283   -13.15395 1.000 20.82029 ? 299 MET A N    1 
ATOM   1653 C CA   . MET A 1 119 ? -15.39691 3.28624   -13.09243 1.000 19.92394 ? 299 MET A CA   1 
ATOM   1654 C C    . MET A 1 119 ? -16.37672 3.72265   -14.17428 1.000 32.79043 ? 299 MET A C    1 
ATOM   1655 O O    . MET A 1 119 ? -17.00576 4.77933   -14.05984 1.000 26.07049 ? 299 MET A O    1 
ATOM   1656 C CB   . MET A 1 119 ? -16.04598 3.34023   -11.71173 1.000 31.81267 ? 299 MET A CB   1 
ATOM   1657 C CG   . MET A 1 119 ? -17.33680 2.53665   -11.60208 1.000 29.07123 ? 299 MET A CG   1 
ATOM   1658 S SD   . MET A 1 119 ? -18.03197 2.53401   -9.93731  1.000 29.02620 ? 299 MET A SD   1 
ATOM   1659 C CE   . MET A 1 119 ? -19.22083 3.86839   -10.06892 1.000 39.18858 ? 299 MET A CE   1 
ATOM   1660 H H    . MET A 1 119 ? -14.31385 4.87729   -12.68195 1.000 25.43640 ? 299 MET A H    1 
ATOM   1661 H HA   . MET A 1 119 ? -15.11741 2.37140   -13.25320 1.000 24.36078 ? 299 MET A HA   1 
ATOM   1662 H HB2  . MET A 1 119 ? -15.42105 2.98527   -11.06029 1.000 38.62725 ? 299 MET A HB2  1 
ATOM   1663 H HB3  . MET A 1 119 ? -16.25466 4.26404   -11.50216 1.000 38.62725 ? 299 MET A HB3  1 
ATOM   1664 H HG2  . MET A 1 119 ? -17.99733 2.91943   -12.20048 1.000 35.33753 ? 299 MET A HG2  1 
ATOM   1665 H HG3  . MET A 1 119 ? -17.15672 1.61673   -11.85153 1.000 35.33753 ? 299 MET A HG3  1 
ATOM   1666 H HE1  . MET A 1 119 ? -19.66031 3.98544   -9.21214  1.000 47.47834 ? 299 MET A HE1  1 
ATOM   1667 H HE2  . MET A 1 119 ? -18.75541 4.68280   -10.31594 1.000 47.47834 ? 299 MET A HE2  1 
ATOM   1668 H HE3  . MET A 1 119 ? -19.87531 3.64239   -10.74824 1.000 47.47834 ? 299 MET A HE3  1 
ATOM   1669 N N    . VAL A 1 120 ? -16.48333 2.92791   -15.23402 1.000 34.46974 ? 300 VAL A N    1 
ATOM   1670 C CA   . VAL A 1 120 ? -17.50648 3.12348   -16.25344 1.000 24.63780 ? 300 VAL A CA   1 
ATOM   1671 C C    . VAL A 1 120 ? -18.75312 2.40039   -15.76131 1.000 23.28288 ? 300 VAL A C    1 
ATOM   1672 O O    . VAL A 1 120 ? -18.75237 1.17406   -15.62561 1.000 28.14862 ? 300 VAL A O    1 
ATOM   1673 C CB   . VAL A 1 120 ? -17.05561 2.59661   -17.62010 1.000 30.94827 ? 300 VAL A CB   1 
ATOM   1674 C CG1  . VAL A 1 120 ? -18.12218 2.86664   -18.67329 1.000 31.68236 ? 300 VAL A CG1  1 
ATOM   1675 C CG2  . VAL A 1 120 ? -15.72852 3.22455   -18.02132 1.000 35.95598 ? 300 VAL A CG2  1 
ATOM   1676 H H    . VAL A 1 120 ? -15.96612 2.25799   -15.38672 1.000 41.81573 ? 300 VAL A H    1 
ATOM   1677 H HA   . VAL A 1 120 ? -17.70099 4.06868   -16.35171 1.000 30.01741 ? 300 VAL A HA   1 
ATOM   1678 H HB   . VAL A 1 120 ? -16.92791 1.63684   -17.56138 1.000 37.58997 ? 300 VAL A HB   1 
ATOM   1679 H HG11 . VAL A 1 120 ? -17.76712 2.64114   -19.54736 1.000 38.47088 ? 300 VAL A HG11 1 
ATOM   1680 H HG12 . VAL A 1 120 ? -18.90068 2.32067   -18.48159 1.000 38.47088 ? 300 VAL A HG12 1 
ATOM   1681 H HG13 . VAL A 1 120 ? -18.36218 3.80609   -18.64607 1.000 38.47088 ? 300 VAL A HG13 1 
ATOM   1682 H HG21 . VAL A 1 120 ? -15.50361 2.93986   -18.92091 1.000 43.59922 ? 300 VAL A HG21 1 
ATOM   1683 H HG22 . VAL A 1 120 ? -15.81436 4.19029   -17.99174 1.000 43.59922 ? 300 VAL A HG22 1 
ATOM   1684 H HG23 . VAL A 1 120 ? -15.04152 2.93438   -17.40105 1.000 43.59922 ? 300 VAL A HG23 1 
ATOM   1685 N N    . ALA A 1 121 ? -19.80938 3.16054   -15.48229 1.000 28.30265 ? 301 ALA A N    1 
ATOM   1686 C CA   . ALA A 1 121 ? -21.02215 2.64553   -14.86584 1.000 26.76680 ? 301 ALA A CA   1 
ATOM   1687 C C    . ALA A 1 121 ? -22.21361 2.89175   -15.77808 1.000 33.63436 ? 301 ALA A C    1 
ATOM   1688 O O    . ALA A 1 121 ? -22.32332 3.95391   -16.40348 1.000 27.54909 ? 301 ALA A O    1 
ATOM   1689 C CB   . ALA A 1 121 ? -21.26921 3.30458   -13.50410 1.000 39.89483 ? 301 ALA A CB   1 
ATOM   1690 H H    . ALA A 1 121 ? -19.84511 4.00381   -15.64727 1.000 34.41523 ? 301 ALA A H    1 
ATOM   1691 H HA   . ALA A 1 121 ? -20.93428 1.68845   -14.73474 1.000 32.57221 ? 301 ALA A HA   1 
ATOM   1692 H HB1  . ALA A 1 121 ? -22.08351 2.94246   -13.12109 1.000 48.32584 ? 301 ALA A HB1  1 
ATOM   1693 H HB2  . ALA A 1 121 ? -20.51721 3.11629   -12.92104 1.000 48.32584 ? 301 ALA A HB2  1 
ATOM   1694 H HB3  . ALA A 1 121 ? -21.35961 4.26230   -13.62852 1.000 48.32584 ? 301 ALA A HB3  1 
ATOM   1695 N N    . CYS A 1 122 ? -23.10379 1.90263   -15.85107 1.000 34.00271 ? 302 CYS A N    1 
ATOM   1696 C CA   . CYS A 1 122 ? -24.32007 1.99558   -16.64628 1.000 32.22144 ? 302 CYS A CA   1 
ATOM   1697 C C    . CYS A 1 122 ? -25.50734 1.57979   -15.79382 1.000 37.40445 ? 302 CYS A C    1 
ATOM   1698 O O    . CYS A 1 122 ? -25.52889 0.46858   -15.25401 1.000 36.96359 ? 302 CYS A O    1 
ATOM   1699 C CB   . CYS A 1 122 ? -24.23688 1.11292   -17.89432 1.000 40.88058 ? 302 CYS A CB   1 
ATOM   1700 S SG   . CYS A 1 122 ? -25.83554 0.84310   -18.70149 1.000 36.42626 ? 302 CYS A SG   1 
ATOM   1701 H H    . CYS A 1 122 ? -23.02033 1.15269   -15.43847 1.000 41.25531 ? 302 CYS A H    1 
ATOM   1702 H HA   . CYS A 1 122 ? -24.44567 2.91726   -16.92129 1.000 39.11778 ? 302 CYS A HA   1 
ATOM   1703 H HB2  . CYS A 1 122 ? -23.64753 1.53683   -18.53765 1.000 49.50875 ? 302 CYS A HB2  1 
ATOM   1704 H HB3  . CYS A 1 122 ? -23.88263 0.24630   -17.64061 1.000 49.50875 ? 302 CYS A HB3  1 
ATOM   1705 H HG   . CYS A 1 122 ? -25.65343 0.30722   -19.75963 1.000 44.16356 ? 302 CYS A HG   1 
ATOM   1706 N N    . TYR A 1 123 ? -26.48581 2.47441   -15.67277 1.000 32.32684 ? 303 TYR A N    1 
ATOM   1707 C CA   . TYR A 1 123 ? -27.79465 2.11966   -15.14600 1.000 34.11929 ? 303 TYR A CA   1 
ATOM   1708 C C    . TYR A 1 123 ? -28.67750 1.77352   -16.33845 1.000 35.42578 ? 303 TYR A C    1 
ATOM   1709 O O    . TYR A 1 123 ? -29.01146 2.67284   -17.12598 1.000 35.73420 ? 303 TYR A O    1 
ATOM   1710 C CB   . TYR A 1 123 ? -28.38999 3.27509   -14.35283 1.000 35.60587 ? 303 TYR A CB   1 
ATOM   1711 C CG   . TYR A 1 123 ? -27.62608 3.62750   -13.09209 1.000 33.60561 ? 303 TYR A CG   1 
ATOM   1712 C CD1  . TYR A 1 123 ? -26.50035 4.43934   -13.14237 1.000 31.97270 ? 303 TYR A CD1  1 
ATOM   1713 C CD2  . TYR A 1 123 ? -28.04072 3.16121   -11.85062 1.000 34.79806 ? 303 TYR A CD2  1 
ATOM   1714 C CE1  . TYR A 1 123 ? -25.80211 4.76805   -11.99431 1.000 31.06211 ? 303 TYR A CE1  1 
ATOM   1715 C CE2  . TYR A 1 123 ? -27.34930 3.48612   -10.69588 1.000 33.41390 ? 303 TYR A CE2  1 
ATOM   1716 C CZ   . TYR A 1 123 ? -26.23112 4.28996   -10.77448 1.000 39.04218 ? 303 TYR A CZ   1 
ATOM   1717 O OH   . TYR A 1 123 ? -25.53879 4.61596   -9.63047  1.000 43.80353 ? 303 TYR A OH   1 
ATOM   1718 H H    . TYR A 1 123 ? -26.41280 3.30271   -15.89228 1.000 36.53197 ? 303 TYR A H    1 
ATOM   1719 H HA   . TYR A 1 123 ? -27.73056 1.35549   -14.55201 1.000 38.68290 ? 303 TYR A HA   1 
ATOM   1720 H HB2  . TYR A 1 123 ? -28.40378 4.06355   -14.91766 1.000 43.17910 ? 303 TYR A HB2  1 
ATOM   1721 H HB3  . TYR A 1 123 ? -29.29366 3.03812   -14.09182 1.000 43.17910 ? 303 TYR A HB3  1 
ATOM   1722 H HD1  . TYR A 1 123 ? -26.21069 4.76794   -13.96275 1.000 36.10699 ? 303 TYR A HD1  1 
ATOM   1723 H HD2  . TYR A 1 123 ? -28.79592 2.62139   -11.79431 1.000 42.20972 ? 303 TYR A HD2  1 
ATOM   1724 H HE1  . TYR A 1 123 ? -25.04717 5.30878   -12.04510 1.000 35.01429 ? 303 TYR A HE1  1 
ATOM   1725 H HE2  . TYR A 1 123 ? -27.63708 3.16431   -9.87215  1.000 37.91511 ? 303 TYR A HE2  1 
ATOM   1726 H HH   . TYR A 1 123 ? -24.88115 5.10240   -9.82144  1.000 53.01629 ? 303 TYR A HH   1 
ATOM   1727 N N    . PRO A 1 124 ? -29.06884 0.49851   -16.53219 1.000 37.70906 ? 304 PRO A N    1 
ATOM   1728 C CA   . PRO A 1 124 ? -29.77895 0.09393   -17.75276 1.000 37.43664 ? 304 PRO A CA   1 
ATOM   1729 C C    . PRO A 1 124 ? -31.28247 0.36513   -17.71350 1.000 42.27910 ? 304 PRO A C    1 
ATOM   1730 O O    . PRO A 1 124 ? -32.09899 -0.51146  -18.00213 1.000 44.18545 ? 304 PRO A O    1 
ATOM   1731 C CB   . PRO A 1 124 ? -29.47464 -1.40478  -17.83666 1.000 37.42585 ? 304 PRO A CB   1 
ATOM   1732 C CG   . PRO A 1 124 ? -29.33126 -1.83273  -16.41877 1.000 37.28760 ? 304 PRO A CG   1 
ATOM   1733 C CD   . PRO A 1 124 ? -28.81444 -0.64886  -15.64052 1.000 36.20536 ? 304 PRO A CD   1 
ATOM   1734 H HA   . PRO A 1 124 ? -29.39614 0.54437   -18.52182 1.000 42.66372 ? 304 PRO A HA   1 
ATOM   1735 H HB2  . PRO A 1 124 ? -30.20797 -1.86940  -18.26939 1.000 42.65077 ? 304 PRO A HB2  1 
ATOM   1736 H HB3  . PRO A 1 124 ? -28.65241 -1.55013  -18.33033 1.000 42.65077 ? 304 PRO A HB3  1 
ATOM   1737 H HG2  . PRO A 1 124 ? -30.19631 -2.10939  -16.07811 1.000 42.48487 ? 304 PRO A HG2  1 
ATOM   1738 H HG3  . PRO A 1 124 ? -28.70342 -2.57040  -16.36822 1.000 42.48487 ? 304 PRO A HG3  1 
ATOM   1739 H HD2  . PRO A 1 124 ? -29.29885 -0.54890  -14.80609 1.000 41.18619 ? 304 PRO A HD2  1 
ATOM   1740 H HD3  . PRO A 1 124 ? -27.86523 -0.74228  -15.46395 1.000 41.18619 ? 304 PRO A HD3  1 
ATOM   1741 N N    . GLY A 1 125 ? -31.65039 1.59351   -17.35884 1.000 39.73466 ? 305 GLY A N    1 
ATOM   1742 C CA   . GLY A 1 125 ? -33.05735 1.93016   -17.30400 1.000 41.74926 ? 305 GLY A CA   1 
ATOM   1743 C C    . GLY A 1 125 ? -33.78985 1.05077   -16.30889 1.000 43.04184 ? 305 GLY A C    1 
ATOM   1744 O O    . GLY A 1 125 ? -33.25121 0.65070   -15.27311 1.000 42.52496 ? 305 GLY A O    1 
ATOM   1745 H H    . GLY A 1 125 ? -31.11336 2.23221   -17.15082 1.000 45.42135 ? 305 GLY A H    1 
ATOM   1746 H HA2  . GLY A 1 125 ? -33.16107 2.85656   -17.03583 1.000 47.83887 ? 305 GLY A HA2  1 
ATOM   1747 H HA3  . GLY A 1 125 ? -33.45648 1.80829   -18.17964 1.000 47.83887 ? 305 GLY A HA3  1 
ATOM   1748 N N    . ASN A 1 126 ? -35.04559 0.74235   -16.63003 1.000 51.42762 ? 306 ASN A N    1 
ATOM   1749 C CA   . ASN A 1 126 ? -35.87448 -0.15906  -15.83254 1.000 46.65434 ? 306 ASN A CA   1 
ATOM   1750 C C    . ASN A 1 126 ? -36.02527 0.31251   -14.38980 1.000 52.47475 ? 306 ASN A C    1 
ATOM   1751 O O    . ASN A 1 126 ? -36.29708 -0.49515  -13.49510 1.000 53.35055 ? 306 ASN A O    1 
ATOM   1752 C CB   . ASN A 1 126 ? -35.31289 -1.58632  -15.85286 1.000 46.84641 ? 306 ASN A CB   1 
ATOM   1753 C CG   . ASN A 1 126 ? -35.24487 -2.16900  -17.25059 1.000 46.28740 ? 306 ASN A CG   1 
ATOM   1754 O OD1  . ASN A 1 126 ? -34.22235 -2.72268  -17.65414 1.000 45.36401 ? 306 ASN A OD1  1 
ATOM   1755 N ND2  . ASN A 1 126 ? -36.33758 -2.05311  -17.99541 1.000 48.04197 ? 306 ASN A ND2  1 
ATOM   1756 H H    . ASN A 1 126 ? -35.44920 1.05139   -17.32371 1.000 62.16520 ? 306 ASN A H    1 
ATOM   1757 H HA   . ASN A 1 126 ? -36.76068 -0.17321  -16.22668 1.000 53.72497 ? 306 ASN A HA   1 
ATOM   1758 H HB2  . ASN A 1 126 ? -34.41447 -1.57788  -15.48724 1.000 56.66774 ? 306 ASN A HB2  1 
ATOM   1759 H HB3  . ASN A 1 126 ? -35.88390 -2.15848  -15.31670 1.000 56.66774 ? 306 ASN A HB3  1 
ATOM   1760 H HD21 . ASN A 1 126 ? -37.03512 -1.66308  -17.67776 1.000 55.39012 ? 306 ASN A HD21 1 
ATOM   1761 H HD22 . ASN A 1 126 ? -36.34794 -2.36807  -18.79560 1.000 55.39012 ? 306 ASN A HD22 1 
ATOM   1762 N N    . GLY A 1 127 ? -35.85176 1.60776   -14.14031 1.000 46.16284 ? 307 GLY A N    1 
ATOM   1763 C CA   . GLY A 1 127 ? -35.98002 2.13907   -12.80038 1.000 46.30337 ? 307 GLY A CA   1 
ATOM   1764 C C    . GLY A 1 127 ? -34.78499 1.91523   -11.90402 1.000 44.51634 ? 307 GLY A C    1 
ATOM   1765 O O    . GLY A 1 127 ? -34.86416 2.21894   -10.70814 1.000 44.68671 ? 307 GLY A O    1 
ATOM   1766 H H    . GLY A 1 127 ? -35.65852 2.19673   -14.73643 1.000 53.13517 ? 307 GLY A H    1 
ATOM   1767 H HA2  . GLY A 1 127 ? -36.12863 3.09577   -12.85980 1.000 53.30380 ? 307 GLY A HA2  1 
ATOM   1768 H HA3  . GLY A 1 127 ? -36.74816 1.72592   -12.37592 1.000 53.30380 ? 307 GLY A HA3  1 
ATOM   1769 N N    . THR A 1 128 ? -33.68321 1.39344   -12.43554 1.000 42.88469 ? 308 THR A N    1 
ATOM   1770 C CA   . THR A 1 128 ? -32.49640 1.16978   -11.62426 1.000 41.19639 ? 308 THR A CA   1 
ATOM   1771 C C    . THR A 1 128 ? -31.90175 2.49753   -11.16694 1.000 43.95186 ? 308 THR A C    1 
ATOM   1772 O O    . THR A 1 128 ? -31.96321 3.51005   -11.87035 1.000 43.36442 ? 308 THR A O    1 
ATOM   1773 C CB   . THR A 1 128 ? -31.43955 0.37970   -12.40134 1.000 39.76929 ? 308 THR A CB   1 
ATOM   1774 O OG1  . THR A 1 128 ? -30.83640 1.22816   -13.38759 1.000 45.33808 ? 308 THR A OG1  1 
ATOM   1775 C CG2  . THR A 1 128 ? -32.03397 -0.87336  -13.05877 1.000 40.97345 ? 308 THR A CG2  1 
ATOM   1776 H H    . THR A 1 128 ? -33.59930 1.16210   -13.25958 1.000 49.20138 ? 308 THR A H    1 
ATOM   1777 H HA   . THR A 1 128 ? -32.74458 0.65128   -10.84294 1.000 47.17542 ? 308 THR A HA   1 
ATOM   1778 H HB   . THR A 1 128 ? -30.75615 0.07218   -11.78547 1.000 47.14339 ? 308 THR A HB   1 
ATOM   1779 H HG1  . THR A 1 128 ? -30.11985 0.88594   -13.66151 1.000 54.85775 ? 308 THR A HG1  1 
ATOM   1780 H HG21 . THR A 1 128 ? -31.47664 -1.15457  -13.80121 1.000 49.22192 ? 308 THR A HG21 1 
ATOM   1781 H HG22 . THR A 1 128 ? -32.08474 -1.59479  -12.41235 1.000 49.22192 ? 308 THR A HG22 1 
ATOM   1782 H HG23 . THR A 1 128 ? -32.92597 -0.68329  -13.38907 1.000 49.22192 ? 308 THR A HG23 1 
ATOM   1783 N N    . GLY A 1 129 ? -31.31986 2.48173   -9.97853  1.000 53.12882 ? 309 GLY A N    1 
ATOM   1784 C CA   . GLY A 1 129 ? -30.71443 3.66714   -9.42248  1.000 38.43967 ? 309 GLY A CA   1 
ATOM   1785 C C    . GLY A 1 129 ? -29.73003 3.32793   -8.32862  1.000 38.84796 ? 309 GLY A C    1 
ATOM   1786 O O    . GLY A 1 129 ? -29.19325 2.22074   -8.26970  1.000 36.53821 ? 309 GLY A O    1 
ATOM   1787 H H    . GLY A 1 129 ? -31.26427 1.78810   -9.47317  1.000 64.20664 ? 309 GLY A H    1 
ATOM   1788 H HA2  . GLY A 1 129 ? -30.24555 4.15000   -10.12097 1.000 46.57965 ? 309 GLY A HA2  1 
ATOM   1789 H HA3  . GLY A 1 129 ? -31.40374 4.23958   -9.05091  1.000 46.57965 ? 309 GLY A HA3  1 
ATOM   1790 N N    . TYR A 1 130 ? -29.49765 4.30421   -7.45421  1.000 36.64132 ? 310 TYR A N    1 
ATOM   1791 C CA   . TYR A 1 130 ? -28.56502 4.15959   -6.34230  1.000 35.57808 ? 310 TYR A CA   1 
ATOM   1792 C C    . TYR A 1 130 ? -29.17728 4.83226   -5.12526  1.000 37.79657 ? 310 TYR A C    1 
ATOM   1793 O O    . TYR A 1 130 ? -29.44445 6.03742   -5.15196  1.000 40.86950 ? 310 TYR A O    1 
ATOM   1794 C CB   . TYR A 1 130 ? -27.20503 4.78052   -6.68018  1.000 36.17854 ? 310 TYR A CB   1 
ATOM   1795 C CG   . TYR A 1 130 ? -26.03885 4.21938   -5.89286  1.000 34.08158 ? 310 TYR A CG   1 
ATOM   1796 C CD1  . TYR A 1 130 ? -26.14985 3.95400   -4.53363  1.000 32.76939 ? 310 TYR A CD1  1 
ATOM   1797 C CD2  . TYR A 1 130 ? -24.82354 3.95790   -6.51283  1.000 30.63040 ? 310 TYR A CD2  1 
ATOM   1798 C CE1  . TYR A 1 130 ? -25.08408 3.44393   -3.81585  1.000 31.68026 ? 310 TYR A CE1  1 
ATOM   1799 C CE2  . TYR A 1 130 ? -23.75299 3.44836   -5.80378  1.000 29.54098 ? 310 TYR A CE2  1 
ATOM   1800 C CZ   . TYR A 1 130 ? -23.88843 3.19277   -4.45646  1.000 38.54853 ? 310 TYR A CZ   1 
ATOM   1801 O OH   . TYR A 1 130 ? -22.82418 2.68461   -3.74825  1.000 29.05832 ? 310 TYR A OH   1 
ATOM   1802 H H    . TYR A 1 130 ? -29.87664 5.07556   -7.48557  1.000 41.70934 ? 310 TYR A H    1 
ATOM   1803 H HA   . TYR A 1 130 ? -28.42781 3.22033   -6.14264  1.000 40.43346 ? 310 TYR A HA   1 
ATOM   1804 H HB2  . TYR A 1 130 ? -27.02225 4.62884   -7.62065  1.000 43.86629 ? 310 TYR A HB2  1 
ATOM   1805 H HB3  . TYR A 1 130 ? -27.24777 5.73266   -6.49988  1.000 43.86629 ? 310 TYR A HB3  1 
ATOM   1806 H HD1  . TYR A 1 130 ? -26.95476 4.12234   -4.09926  1.000 39.13880 ? 310 TYR A HD1  1 
ATOM   1807 H HD2  . TYR A 1 130 ? -24.72885 4.12903   -7.42203  1.000 34.49623 ? 310 TYR A HD2  1 
ATOM   1808 H HE1  . TYR A 1 130 ? -25.17268 3.27111   -2.90635  1.000 37.82244 ? 310 TYR A HE1  1 
ATOM   1809 H HE2  . TYR A 1 130 ? -22.94567 3.27883   -6.23320  1.000 33.18894 ? 310 TYR A HE2  1 
ATOM   1810 H HH   . TYR A 1 130 ? -23.03598 2.58813   -2.94114  1.000 34.47765 ? 310 TYR A HH   1 
ATOM   1811 N N    . VAL A 1 131 ? -29.39520 4.05646   -4.06011  1.000 37.29861 ? 311 VAL A N    1 
ATOM   1812 C CA   . VAL A 1 131 ? -30.01328 4.61448   -2.86468  1.000 38.39503 ? 311 VAL A CA   1 
ATOM   1813 C C    . VAL A 1 131 ? -29.10524 5.68553   -2.25947  1.000 37.06588 ? 311 VAL A C    1 
ATOM   1814 O O    . VAL A 1 131 ? -27.90691 5.77268   -2.55483  1.000 35.32021 ? 311 VAL A O    1 
ATOM   1815 C CB   . VAL A 1 131 ? -30.32664 3.51672   -1.83462  1.000 47.82289 ? 311 VAL A CB   1 
ATOM   1816 C CG1  . VAL A 1 131 ? -30.92157 2.29126   -2.51549  1.000 40.38834 ? 311 VAL A CG1  1 
ATOM   1817 C CG2  . VAL A 1 131 ? -29.07362 3.13880   -1.05517  1.000 42.01945 ? 311 VAL A CG2  1 
ATOM   1818 H H    . VAL A 1 131 ? -29.19746 3.22113   -4.00788  1.000 44.32552 ? 311 VAL A H    1 
ATOM   1819 H HA   . VAL A 1 131 ? -30.85001 5.03645   -3.11513  1.000 43.81379 ? 311 VAL A HA   1 
ATOM   1820 H HB   . VAL A 1 131 ? -30.98195 3.86023   -1.20734  1.000 57.83952 ? 311 VAL A HB   1 
ATOM   1821 H HG11 . VAL A 1 131 ? -31.40019 1.76484   -1.85617  1.000 46.74241 ? 311 VAL A HG11 1 
ATOM   1822 H HG12 . VAL A 1 131 ? -31.53060 2.58166   -3.21238  1.000 46.74241 ? 311 VAL A HG12 1 
ATOM   1823 H HG13 . VAL A 1 131 ? -30.20403 1.76492   -2.90150  1.000 46.74241 ? 311 VAL A HG13 1 
ATOM   1824 H HG21 . VAL A 1 131 ? -29.20757 2.27074   -0.64356  1.000 50.87538 ? 311 VAL A HG21 1 
ATOM   1825 H HG22 . VAL A 1 131 ? -28.32077 3.10274   -1.66575  1.000 50.87538 ? 311 VAL A HG22 1 
ATOM   1826 H HG23 . VAL A 1 131 ? -28.91323 3.80788   -0.37143  1.000 50.87538 ? 311 VAL A HG23 1 
ATOM   1827 N N    . ARG A 1 132 ? -29.69795 6.51304   -1.40013  1.000 38.02461 ? 312 ARG A N    1 
ATOM   1828 C CA   . ARG A 1 132 ? -28.95685 7.56609   -0.71651  1.000 37.02737 ? 312 ARG A CA   1 
ATOM   1829 C C    . ARG A 1 132 ? -27.75375 6.98250   0.01225   1.000 40.77583 ? 312 ARG A C    1 
ATOM   1830 O O    . ARG A 1 132 ? -27.87368 5.99340   0.73997   1.000 36.30939 ? 312 ARG A O    1 
ATOM   1831 C CB   . ARG A 1 132 ? -29.88306 8.27915   0.27055   1.000 39.39088 ? 312 ARG A CB   1 
ATOM   1832 C CG   . ARG A 1 132 ? -29.40809 9.64322   0.73318   1.000 37.89349 ? 312 ARG A CG   1 
ATOM   1833 C CD   . ARG A 1 132 ? -29.86744 9.90148   2.16069   1.000 49.52919 ? 312 ARG A CD   1 
ATOM   1834 N NE   . ARG A 1 132 ? -29.85887 11.31931  2.50480   1.000 55.04319 ? 312 ARG A NE   1 
ATOM   1835 C CZ   . ARG A 1 132 ? -29.33058 11.83240  3.60986   1.000 64.00858 ? 312 ARG A CZ   1 
ATOM   1836 N NH1  . ARG A 1 132 ? -28.73755 11.07178  4.51694   1.000 68.42725 ? 312 ARG A NH1  1 
ATOM   1837 N NH2  . ARG A 1 132 ? -29.40233 13.14472  3.81228   1.000 65.11344 ? 312 ARG A NH2  1 
ATOM   1838 H H    . ARG A 1 132 ? -30.53274 6.48433   -1.19545  1.000 43.79268 ? 312 ARG A H    1 
ATOM   1839 H HA   . ARG A 1 132 ? -28.63510 8.21514   -1.36159  1.000 42.17260 ? 312 ARG A HA   1 
ATOM   1840 H HB2  . ARG A 1 132 ? -30.74663 8.40158   -0.15389  1.000 47.72110 ? 312 ARG A HB2  1 
ATOM   1841 H HB3  . ARG A 1 132 ? -29.97696 7.72218   1.05913   1.000 47.72110 ? 312 ARG A HB3  1 
ATOM   1842 H HG2  . ARG A 1 132 ? -28.43902 9.67742   0.70777   1.000 43.21194 ? 312 ARG A HG2  1 
ATOM   1843 H HG3  . ARG A 1 132 ? -29.77950 10.33055  0.15826   1.000 43.21194 ? 312 ARG A HG3  1 
ATOM   1844 H HD2  . ARG A 1 132 ? -30.77369 9.57219   2.26640   1.000 59.88708 ? 312 ARG A HD2  1 
ATOM   1845 H HD3  . ARG A 1 132 ? -29.27329 9.44014   2.77310   1.000 59.88708 ? 312 ARG A HD3  1 
ATOM   1846 H HE   . ARG A 1 132 ? -30.22407 11.86477  1.94919   1.000 66.50388 ? 312 ARG A HE   1 
ATOM   1847 H HH11 . ARG A 1 132 ? -28.68692 10.22148  4.39849   1.000 82.56475 ? 312 ARG A HH11 1 
ATOM   1848 H HH12 . ARG A 1 132 ? -28.40298 11.42803  5.22458   1.000 82.56475 ? 312 ARG A HH12 1 
ATOM   1849 H HH21 . ARG A 1 132 ? -29.78704 13.64899  3.23149   1.000 78.58818 ? 312 ARG A HH21 1 
ATOM   1850 H HH22 . ARG A 1 132 ? -29.06403 13.48916  4.52397   1.000 78.58818 ? 312 ARG A HH22 1 
ATOM   1851 N N    . HIS A 1 133 ? -26.59118 7.60277   -0.18097  1.000 42.75507 ? 313 HIS A N    1 
ATOM   1852 C CA   . HIS A 1 133 ? -25.34820 7.04373   0.33327   1.000 39.82952 ? 313 HIS A CA   1 
ATOM   1853 C C    . HIS A 1 133 ? -24.26854 8.11725   0.34735   1.000 35.87309 ? 313 HIS A C    1 
ATOM   1854 O O    . HIS A 1 133 ? -24.42135 9.19518   -0.23298  1.000 30.96303 ? 313 HIS A O    1 
ATOM   1855 C CB   . HIS A 1 133 ? -24.89891 5.84406   -0.50666  1.000 32.87578 ? 313 HIS A CB   1 
ATOM   1856 C CG   . HIS A 1 133 ? -24.41457 6.21591   -1.87390  1.000 30.84073 ? 313 HIS A CG   1 
ATOM   1857 N ND1  . HIS A 1 133 ? -25.26987 6.56723   -2.89607  1.000 31.57500 ? 313 HIS A ND1  1 
ATOM   1858 C CD2  . HIS A 1 133 ? -23.16351 6.29949   -2.38520  1.000 29.13571 ? 313 HIS A CD2  1 
ATOM   1859 C CE1  . HIS A 1 133 ? -24.56708 6.84663   -3.97924  1.000 31.22882 ? 313 HIS A CE1  1 
ATOM   1860 N NE2  . HIS A 1 133 ? -23.28628 6.69301   -3.69579  1.000 30.30894 ? 313 HIS A NE2  1 
ATOM   1861 H H    . HIS A 1 133 ? -26.49877 8.34519   -0.60509  1.000 51.75813 ? 313 HIS A H    1 
ATOM   1862 H HA   . HIS A 1 133 ? -25.49441 6.75980   1.24920   1.000 48.24748 ? 313 HIS A HA   1 
ATOM   1863 H HB2  . HIS A 1 133 ? -24.17241 5.39524   -0.04660  1.000 39.90299 ? 313 HIS A HB2  1 
ATOM   1864 H HB3  . HIS A 1 133 ? -25.64912 5.23833   -0.61239  1.000 39.90299 ? 313 HIS A HB3  1 
ATOM   1865 H HD1  . HIS A 1 133 ? -26.12728 6.59951   -2.83781  1.000 37.38423 ? 313 HIS A HD1  1 
ATOM   1866 H HD2  . HIS A 1 133 ? -22.36973 6.12347   -1.93372  1.000 33.76546 ? 313 HIS A HD2  1 
ATOM   1867 H HE1  . HIS A 1 133 ? -24.91500 7.10716   -4.80142  1.000 37.92663 ? 313 HIS A HE1  1 
ATOM   1868 N N    . VAL A 1 134 ? -23.16764 7.79735   1.02746   1.000 36.04913 ? 314 VAL A N    1 
ATOM   1869 C CA   . VAL A 1 134 ? -21.96634 8.62264   1.06447   1.000 37.93860 ? 314 VAL A CA   1 
ATOM   1870 C C    . VAL A 1 134 ? -20.82896 7.82686   0.44009   1.000 34.13653 ? 314 VAL A C    1 
ATOM   1871 O O    . VAL A 1 134 ? -20.65870 6.63832   0.73320   1.000 31.03905 ? 314 VAL A O    1 
ATOM   1872 C CB   . VAL A 1 134 ? -21.60490 9.04936   2.50277   1.000 33.49184 ? 314 VAL A CB   1 
ATOM   1873 C CG1  . VAL A 1 134 ? -20.20256 9.64320   2.54745   1.000 29.76617 ? 314 VAL A CG1  1 
ATOM   1874 C CG2  . VAL A 1 134 ? -22.62528 10.04168  3.03548   1.000 30.48067 ? 314 VAL A CG2  1 
ATOM   1875 H H    . VAL A 1 134 ? -23.09247 7.07798   1.49270   1.000 43.71101 ? 314 VAL A H    1 
ATOM   1876 H HA   . VAL A 1 134 ? -22.11237 9.42670   0.54192   1.000 45.97836 ? 314 VAL A HA   1 
ATOM   1877 H HB   . VAL A 1 134 ? -21.61844 8.26627   3.07503   1.000 40.64226 ? 314 VAL A HB   1 
ATOM   1878 H HG11 . VAL A 1 134 ? -20.08480 10.11203  3.38842   1.000 36.17146 ? 314 VAL A HG11 1 
ATOM   1879 H HG12 . VAL A 1 134 ? -19.55347 8.92605   2.47483   1.000 36.17146 ? 314 VAL A HG12 1 
ATOM   1880 H HG13 . VAL A 1 134 ? -20.09739 10.26078  1.80689   1.000 36.17146 ? 314 VAL A HG13 1 
ATOM   1881 H HG21 . VAL A 1 134 ? -22.38099 10.29064  3.94060   1.000 37.02885 ? 314 VAL A HG21 1 
ATOM   1882 H HG22 . VAL A 1 134 ? -22.62924 10.82695  2.46607   1.000 37.02885 ? 314 VAL A HG22 1 
ATOM   1883 H HG23 . VAL A 1 134 ? -23.50172 9.62605   3.03187   1.000 37.02885 ? 314 VAL A HG23 1 
ATOM   1884 N N    . ASP A 1 135 ? -20.05220 8.48294   -0.42452  1.000 27.72209 ? 315 ASP A N    1 
ATOM   1885 C CA   . ASP A 1 135 ? -19.01046 7.77179   -1.15979  1.000 29.35125 ? 315 ASP A CA   1 
ATOM   1886 C C    . ASP A 1 135 ? -17.90865 7.26640   -0.23378  1.000 33.90199 ? 315 ASP A C    1 
ATOM   1887 O O    . ASP A 1 135 ? -17.45287 6.12555   -0.37399  1.000 26.44609 ? 315 ASP A O    1 
ATOM   1888 C CB   . ASP A 1 135 ? -18.42769 8.67524   -2.24624  1.000 23.52358 ? 315 ASP A CB   1 
ATOM   1889 C CG   . ASP A 1 135 ? -19.26821 8.68228   -3.51053  1.000 30.58126 ? 315 ASP A CG   1 
ATOM   1890 O OD1  . ASP A 1 135 ? -20.30618 7.98628   -3.54224  1.000 28.00596 ? 315 ASP A OD1  1 
ATOM   1891 O OD2  . ASP A 1 135 ? -18.89116 9.38147   -4.47427  1.000 23.42922 ? 315 ASP A OD2  1 
ATOM   1892 H H    . ASP A 1 135 ? -20.10757 9.32315   -0.59940  1.000 33.71855 ? 315 ASP A H    1 
ATOM   1893 H HA   . ASP A 1 135 ? -19.41031 6.99948   -1.58940  1.000 35.67355 ? 315 ASP A HA   1 
ATOM   1894 H HB2  . ASP A 1 135 ? -18.38097 9.58428   -1.91104  1.000 27.94614 ? 315 ASP A HB2  1 
ATOM   1895 H HB3  . ASP A 1 135 ? -17.53963 8.36075   -2.47719  1.000 27.94614 ? 315 ASP A HB3  1 
ATOM   1896 N N    . ASN A 1 136 ? -17.45936 8.09572   0.70893   1.000 29.31776 ? 316 ASN A N    1 
ATOM   1897 C CA   . ASN A 1 136 ? -16.38753 7.73793   1.64032   1.000 26.88787 ? 316 ASN A CA   1 
ATOM   1898 C C    . ASN A 1 136 ? -16.79422 8.14573   3.04998   1.000 28.29897 ? 316 ASN A C    1 
ATOM   1899 O O    . ASN A 1 136 ? -16.36735 9.19295   3.55469   1.000 24.53182 ? 316 ASN A O    1 
ATOM   1900 C CB   . ASN A 1 136 ? -15.06572 8.39656   1.24198   1.000 21.25619 ? 316 ASN A CB   1 
ATOM   1901 C CG   . ASN A 1 136 ? -13.96439 8.15276   2.25581   1.000 24.91619 ? 316 ASN A CG   1 
ATOM   1902 O OD1  . ASN A 1 136 ? -14.06804 7.26483   3.10379   1.000 21.14040 ? 316 ASN A OD1  1 
ATOM   1903 N ND2  . ASN A 1 136 ? -12.89935 8.93947   2.17088   1.000 20.56630 ? 316 ASN A ND2  1 
ATOM   1904 H H    . ASN A 1 136 ? -17.76702 8.88943   0.83128   1.000 35.63336 ? 316 ASN A H    1 
ATOM   1905 H HA   . ASN A 1 136 ? -16.27413 6.77468   1.62678   1.000 32.71749 ? 316 ASN A HA   1 
ATOM   1906 H HB2  . ASN A 1 136 ? -14.77561 8.03464   0.39007   1.000 23.24718 ? 316 ASN A HB2  1 
ATOM   1907 H HB3  . ASN A 1 136 ? -15.19899 9.35447   1.16739   1.000 23.24718 ? 316 ASN A HB3  1 
ATOM   1908 H HD21 . ASN A 1 136 ? -12.24723 8.84144   2.72291   1.000 25.13161 ? 316 ASN A HD21 1 
ATOM   1909 H HD22 . ASN A 1 136 ? -12.86114 9.54742   1.56381   1.000 25.13161 ? 316 ASN A HD22 1 
ATOM   1910 N N    . PRO A 1 137 ? -17.61689 7.33907   3.71994   1.000 30.57875 ? 317 PRO A N    1 
ATOM   1911 C CA   . PRO A 1 137 ? -18.06776 7.71191   5.06760   1.000 37.02048 ? 317 PRO A CA   1 
ATOM   1912 C C    . PRO A 1 137 ? -17.05196 7.41923   6.16333   1.000 33.42295 ? 317 PRO A C    1 
ATOM   1913 O O    . PRO A 1 137 ? -17.00533 8.13863   7.16631   1.000 41.01975 ? 317 PRO A O    1 
ATOM   1914 C CB   . PRO A 1 137 ? -19.33866 6.87274   5.24927   1.000 27.46456 ? 317 PRO A CB   1 
ATOM   1915 C CG   . PRO A 1 137 ? -19.11204 5.66925   4.40223   1.000 34.98758 ? 317 PRO A CG   1 
ATOM   1916 C CD   . PRO A 1 137 ? -18.27872 6.11662   3.22916   1.000 34.77007 ? 317 PRO A CD   1 
ATOM   1917 H HA   . PRO A 1 137 ? -18.28127 8.65790   5.08798   1.000 44.87663 ? 317 PRO A HA   1 
ATOM   1918 H HB2  . PRO A 1 137 ? -19.44536 6.62841   6.18191   1.000 32.94351 ? 317 PRO A HB2  1 
ATOM   1919 H HB3  . PRO A 1 137 ? -20.11309 7.37221   4.94646   1.000 32.94351 ? 317 PRO A HB3  1 
ATOM   1920 H HG2  . PRO A 1 137 ? -18.64134 4.99509   4.91687   1.000 42.43714 ? 317 PRO A HG2  1 
ATOM   1921 H HG3  . PRO A 1 137 ? -19.96534 5.32042   4.10040   1.000 42.43714 ? 317 PRO A HG3  1 
ATOM   1922 H HD2  . PRO A 1 137 ? -17.62334 5.44089   2.99511   1.000 42.17613 ? 317 PRO A HD2  1 
ATOM   1923 H HD3  . PRO A 1 137 ? -18.84044 6.31335   2.46323   1.000 42.17613 ? 317 PRO A HD3  1 
ATOM   1924 N N    . ASN A 1 138 ? -16.23818 6.37683   5.99568   1.000 33.53543 ? 318 ASN A N    1 
ATOM   1925 C CA   . ASN A 1 138 ? -15.30692 5.93098   7.02780   1.000 34.77240 ? 318 ASN A CA   1 
ATOM   1926 C C    . ASN A 1 138 ? -13.85482 6.09415   6.58828   1.000 30.07823 ? 318 ASN A C    1 
ATOM   1927 O O    . ASN A 1 138 ? -12.99649 5.26274   6.89368   1.000 25.50002 ? 318 ASN A O    1 
ATOM   1928 C CB   . ASN A 1 138 ? -15.58256 4.48134   7.42542   1.000 36.24187 ? 318 ASN A CB   1 
ATOM   1929 C CG   . ASN A 1 138 ? -17.04340 4.23136   7.75367   1.000 41.42563 ? 318 ASN A CG   1 
ATOM   1930 O OD1  . ASN A 1 138 ? -17.90744 5.06047   7.47276   1.000 46.16139 ? 318 ASN A OD1  1 
ATOM   1931 N ND2  . ASN A 1 138 ? -17.32491 3.08135   8.35580   1.000 49.82943 ? 318 ASN A ND2  1 
ATOM   1932 H H    . ASN A 1 138 ? -16.20841 5.90428   5.27776   1.000 40.69457 ? 318 ASN A H    1 
ATOM   1933 H HA   . ASN A 1 138 ? -15.44044 6.49317   7.80691   1.000 42.17893 ? 318 ASN A HA   1 
ATOM   1934 H HB2  . ASN A 1 138 ? -15.33641 3.89927   6.68955   1.000 43.94229 ? 318 ASN A HB2  1 
ATOM   1935 H HB3  . ASN A 1 138 ? -15.05687 4.26342   8.21095   1.000 43.94229 ? 318 ASN A HB3  1 
ATOM   1936 H HD21 . ASN A 1 138 ? -16.69423 2.52595   8.53849   1.000 60.24736 ? 318 ASN A HD21 1 
ATOM   1937 H HD22 . ASN A 1 138 ? -18.13787 2.89216   8.56296   1.000 60.24736 ? 318 ASN A HD22 1 
ATOM   1938 N N    . GLY A 1 139 ? -13.56453 7.17258   5.86452   1.000 22.62568 ? 319 GLY A N    1 
ATOM   1939 C CA   . GLY A 1 139 ? -12.19412 7.58419   5.62662   1.000 25.88278 ? 319 GLY A CA   1 
ATOM   1940 C C    . GLY A 1 139 ? -11.31415 6.59339   4.89188   1.000 23.85543 ? 319 GLY A C    1 
ATOM   1941 O O    . GLY A 1 139 ? -10.21200 6.28666   5.35666   1.000 22.91499 ? 319 GLY A O    1 
ATOM   1942 H H    . GLY A 1 139 ? -14.15152 7.68405   5.49921   1.000 27.60286 ? 319 GLY A H    1 
ATOM   1943 H HA2  . GLY A 1 139 ? -12.20684 8.40183   5.10489   1.000 31.51138 ? 319 GLY A HA2  1 
ATOM   1944 H HA3  . GLY A 1 139 ? -11.77559 7.76268   6.48328   1.000 31.51138 ? 319 GLY A HA3  1 
ATOM   1945 N N    . ASP A 1 140 ? -11.77550 6.08032   3.75236   1.000 25.33397 ? 320 ASP A N    1 
ATOM   1946 C CA   . ASP A 1 140 ? -10.96170 5.17946   2.94371   1.000 24.96190 ? 320 ASP A CA   1 
ATOM   1947 C C    . ASP A 1 140 ? -9.99215  5.91852   2.02339   1.000 21.95318 ? 320 ASP A C    1 
ATOM   1948 O O    . ASP A 1 140 ? -9.42109  5.29545   1.12073   1.000 21.18865 ? 320 ASP A O    1 
ATOM   1949 C CB   . ASP A 1 140 ? -11.86041 4.24687   2.12349   1.000 21.11272 ? 320 ASP A CB   1 
ATOM   1950 C CG   . ASP A 1 140 ? -12.64263 4.97396   1.04389   1.000 23.51123 ? 320 ASP A CG   1 
ATOM   1951 O OD1  . ASP A 1 140 ? -12.42235 6.18569   0.83975   1.000 23.61140 ? 320 ASP A OD1  1 
ATOM   1952 O OD2  . ASP A 1 140 ? -13.48937 4.32465   0.39451   1.000 23.83968 ? 320 ASP A OD2  1 
ATOM   1953 H H    . ASP A 1 140 ? -12.55599 6.23984   3.42835   1.000 30.85281 ? 320 ASP A H    1 
ATOM   1954 H HA   . ASP A 1 140 ? -10.43318 4.62605   3.53978   1.000 30.40633 ? 320 ASP A HA   1 
ATOM   1955 H HB2  . ASP A 1 140 ? -11.30817 3.57623   1.69201   1.000 25.78731 ? 320 ASP A HB2  1 
ATOM   1956 H HB3  . ASP A 1 140 ? -12.49725 3.82000   2.71772   1.000 25.78731 ? 320 ASP A HB3  1 
ATOM   1957 N N    . GLY A 1 141 ? -9.79661  7.22204   2.22772   1.000 22.33681 ? 321 GLY A N    1 
ATOM   1958 C CA   . GLY A 1 141 ? -8.82120  7.99647   1.49581   1.000 17.46963 ? 321 GLY A CA   1 
ATOM   1959 C C    . GLY A 1 141 ? -9.38828  8.86264   0.38911   1.000 16.58031 ? 321 GLY A C    1 
ATOM   1960 O O    . GLY A 1 141 ? -8.71363  9.80337   -0.04507  1.000 15.40146 ? 321 GLY A O    1 
ATOM   1961 H H    . GLY A 1 141 ? -10.23515 7.68497   2.80477   1.000 27.25622 ? 321 GLY A H    1 
ATOM   1962 H HA2  . GLY A 1 141 ? -8.35791  8.57892   2.11791   1.000 21.41560 ? 321 GLY A HA2  1 
ATOM   1963 H HA3  . GLY A 1 141 ? -8.18022  7.38856   1.09520   1.000 21.41560 ? 321 GLY A HA3  1 
ATOM   1964 N N    . ARG A 1 142 ? -10.60092 8.57821   -0.07672  1.000 21.17010 ? 322 ARG A N    1 
ATOM   1965 C CA   . ARG A 1 142 ? -11.19278 9.37182   -1.14550  1.000 17.02952 ? 322 ARG A CA   1 
ATOM   1966 C C    . ARG A 1 142 ? -11.61755 10.73375  -0.61158  1.000 17.46525 ? 322 ARG A C    1 
ATOM   1967 O O    . ARG A 1 142 ? -12.30785 10.82241  0.40796   1.000 18.34096 ? 322 ARG A O    1 
ATOM   1968 C CB   . ARG A 1 142 ? -12.39307 8.63978   -1.74104  1.000 18.31982 ? 322 ARG A CB   1 
ATOM   1969 C CG   . ARG A 1 142 ? -12.05331 7.29309   -2.35828  1.000 17.59072 ? 322 ARG A CG   1 
ATOM   1970 C CD   . ARG A 1 142 ? -13.28532 6.62433   -2.94456  1.000 18.58524 ? 322 ARG A CD   1 
ATOM   1971 N NE   . ARG A 1 142 ? -13.86548 5.65414   -2.02383  1.000 23.31040 ? 322 ARG A NE   1 
ATOM   1972 C CZ   . ARG A 1 142 ? -14.94395 4.92668   -2.28060  1.000 20.51342 ? 322 ARG A CZ   1 
ATOM   1973 N NH1  . ARG A 1 142 ? -15.59070 5.03084   -3.42973  1.000 20.82116 ? 322 ARG A NH1  1 
ATOM   1974 N NH2  . ARG A 1 142 ? -15.38466 4.07258   -1.36041  1.000 22.93276 ? 322 ARG A NH2  1 
ATOM   1975 H H    . ARG A 1 142 ? -11.09711 7.93580   0.20737   1.000 25.85617 ? 322 ARG A H    1 
ATOM   1976 H HA   . ARG A 1 142 ? -10.53910 9.50760   -1.84918  1.000 18.17517 ? 322 ARG A HA   1 
ATOM   1977 H HB2  . ARG A 1 142 ? -13.04348 8.48628   -1.03797  1.000 22.43584 ? 322 ARG A HB2  1 
ATOM   1978 H HB3  . ARG A 1 142 ? -12.78089 9.19357   -2.43661  1.000 22.43584 ? 322 ARG A HB3  1 
ATOM   1979 H HG2  . ARG A 1 142 ? -11.40684 7.41962   -3.07030  1.000 21.07889 ? 322 ARG A HG2  1 
ATOM   1980 H HG3  . ARG A 1 142 ? -11.68535 6.71021   -1.67582  1.000 21.07889 ? 322 ARG A HG3  1 
ATOM   1981 H HD2  . ARG A 1 142 ? -13.95505 7.29937   -3.13611  1.000 20.04204 ? 322 ARG A HD2  1 
ATOM   1982 H HD3  . ARG A 1 142 ? -13.03968 6.15994   -3.75997  1.000 20.04204 ? 322 ARG A HD3  1 
ATOM   1983 H HE   . ARG A 1 142 ? -13.48182 5.54623   -1.26175  1.000 28.42453 ? 322 ARG A HE   1 
ATOM   1984 H HH11 . ARG A 1 142 ? -15.31367 5.57995   -4.03084  1.000 23.42460 ? 322 ARG A HH11 1 
ATOM   1985 H HH12 . ARG A 1 142 ? -16.28823 4.54945   -3.57574  1.000 23.42460 ? 322 ARG A HH12 1 
ATOM   1986 H HH21 . ARG A 1 142 ? -14.97102 3.99755   -0.61016  1.000 27.97136 ? 322 ARG A HH21 1 
ATOM   1987 H HH22 . ARG A 1 142 ? -16.08314 3.59557   -1.51592  1.000 27.97136 ? 322 ARG A HH22 1 
ATOM   1988 N N    . CYS A 1 143 ? -11.20475 11.79730  -1.30033  1.000 16.92487 ? 323 CYS A N    1 
ATOM   1989 C CA   . CYS A 1 143 ? -11.55948 13.15492  -0.91390  1.000 19.49863 ? 323 CYS A CA   1 
ATOM   1990 C C    . CYS A 1 143 ? -12.34727 13.90933  -1.97389  1.000 23.10426 ? 323 CYS A C    1 
ATOM   1991 O O    . CYS A 1 143 ? -13.10324 14.81718  -1.62190  1.000 19.40096 ? 323 CYS A O    1 
ATOM   1992 C CB   . CYS A 1 143 ? -10.29577 13.96023  -0.56611  1.000 16.44734 ? 323 CYS A CB   1 
ATOM   1993 S SG   . CYS A 1 143 ? -9.18859  14.27903  -1.95498  1.000 20.26027 ? 323 CYS A SG   1 
ATOM   1994 H H    . CYS A 1 143 ? -10.71196 11.75394  -2.00381  1.000 20.47706 ? 323 CYS A H    1 
ATOM   1995 H HA   . CYS A 1 143 ? -12.11090 13.11326  -0.11697  1.000 23.85041 ? 323 CYS A HA   1 
ATOM   1996 H HB2  . CYS A 1 143 ? -10.56831 14.81956  -0.20809  1.000 17.47656 ? 323 CYS A HB2  1 
ATOM   1997 H HB3  . CYS A 1 143 ? -9.79186  13.46780  0.10060   1.000 17.47656 ? 323 CYS A HB3  1 
ATOM   1998 H HG   . CYS A 1 143 ? -8.80201  13.23161  -2.39484  1.000 24.76437 ? 323 CYS A HG   1 
ATOM   1999 N N    . VAL A 1 144 ? -12.19690 13.56612  -3.25216  1.000 19.19320 ? 324 VAL A N    1 
ATOM   2000 C CA   . VAL A 1 144 ? -12.93109 14.21194  -4.33381  1.000 17.75361 ? 324 VAL A CA   1 
ATOM   2001 C C    . VAL A 1 144 ? -13.48821 13.13961  -5.25824  1.000 18.02584 ? 324 VAL A C    1 
ATOM   2002 O O    . VAL A 1 144 ? -12.75528 12.24134  -5.68724  1.000 18.60211 ? 324 VAL A O    1 
ATOM   2003 C CB   . VAL A 1 144 ? -12.04289 15.19011  -5.12669  1.000 16.95440 ? 324 VAL A CB   1 
ATOM   2004 C CG1  . VAL A 1 144 ? -12.76346 15.65961  -6.38216  1.000 23.63356 ? 324 VAL A CG1  1 
ATOM   2005 C CG2  . VAL A 1 144 ? -11.64738 16.37242  -4.25733  1.000 17.45460 ? 324 VAL A CG2  1 
ATOM   2006 H H    . VAL A 1 144 ? -11.66299 12.94797  -3.52129  1.000 23.48389 ? 324 VAL A H    1 
ATOM   2007 H HA   . VAL A 1 144 ? -13.67592 14.70519  -3.95587  1.000 19.04409 ? 324 VAL A HA   1 
ATOM   2008 H HB   . VAL A 1 144 ? -11.23150 14.73283  -5.39768  1.000 18.08504 ? 324 VAL A HB   1 
ATOM   2009 H HG11 . VAL A 1 144 ? -12.34162 16.47191  -6.70329  1.000 28.81232 ? 324 VAL A HG11 1 
ATOM   2010 H HG12 . VAL A 1 144 ? -12.70412 14.96653  -7.05819  1.000 28.81232 ? 324 VAL A HG12 1 
ATOM   2011 H HG13 . VAL A 1 144 ? -13.69323 15.83268  -6.16659  1.000 28.81232 ? 324 VAL A HG13 1 
ATOM   2012 H HG21 . VAL A 1 144 ? -11.08167 16.96826  -4.77292  1.000 21.39757 ? 324 VAL A HG21 1 
ATOM   2013 H HG22 . VAL A 1 144 ? -12.44947 16.83941  -3.97541  1.000 21.39757 ? 324 VAL A HG22 1 
ATOM   2014 H HG23 . VAL A 1 144 ? -11.16448 16.04656  -3.48175  1.000 21.39757 ? 324 VAL A HG23 1 
ATOM   2015 N N    . THR A 1 145 ? -14.77778 13.23951  -5.56767  1.000 19.20061 ? 325 THR A N    1 
ATOM   2016 C CA   . THR A 1 145 ? -15.42646 12.40915  -6.56931  1.000 19.55390 ? 325 THR A CA   1 
ATOM   2017 C C    . THR A 1 145 ? -15.57464 13.22319  -7.84560  1.000 24.06354 ? 325 THR A C    1 
ATOM   2018 O O    . THR A 1 145 ? -16.08310 14.35221  -7.81150  1.000 20.65489 ? 325 THR A O    1 
ATOM   2019 C CB   . THR A 1 145 ? -16.79887 11.93375  -6.09148  1.000 20.92546 ? 325 THR A CB   1 
ATOM   2020 O OG1  . THR A 1 145 ? -16.65854 11.21235  -4.86189  1.000 21.00203 ? 325 THR A OG1  1 
ATOM   2021 C CG2  . THR A 1 145 ? -17.45206 11.04123  -7.13994  1.000 21.42990 ? 325 THR A CG2  1 
ATOM   2022 H H    . THR A 1 145 ? -15.31328 13.80094  -5.19667  1.000 23.49278 ? 325 THR A H    1 
ATOM   2023 H HA   . THR A 1 145 ? -14.88542 11.62384  -6.74672  1.000 22.22344 ? 325 THR A HA   1 
ATOM   2024 H HB   . THR A 1 145 ? -17.37500 12.70059  -5.94684  1.000 22.85031 ? 325 THR A HB   1 
ATOM   2025 H HG1  . THR A 1 145 ? -17.41022 10.94679  -4.59721  1.000 22.94220 ? 325 THR A HG1  1 
ATOM   2026 H HG21 . THR A 1 145 ? -18.23796 10.61196  -6.76712  1.000 23.78144 ? 325 THR A HG21 1 
ATOM   2027 H HG22 . THR A 1 145 ? -17.71725 11.57105  -7.90797  1.000 23.78144 ? 325 THR A HG22 1 
ATOM   2028 H HG23 . THR A 1 145 ? -16.82756 10.35779  -7.42945  1.000 23.78144 ? 325 THR A HG23 1 
ATOM   2029 N N    . CYS A 1 146 ? -15.12621 12.65052  -8.96020  1.000 19.03674 ? 326 CYS A N    1 
ATOM   2030 C CA   . CYS A 1 146 ? -15.16166 13.29896  -10.26293 1.000 19.02532 ? 326 CYS A CA   1 
ATOM   2031 C C    . CYS A 1 146 ? -15.90452 12.39050  -11.23148 1.000 20.86128 ? 326 CYS A C    1 
ATOM   2032 O O    . CYS A 1 146 ? -15.53983 11.22153  -11.39340 1.000 22.45688 ? 326 CYS A O    1 
ATOM   2033 C CB   . CYS A 1 146 ? -13.74515 13.59040  -10.76128 1.000 26.20154 ? 326 CYS A CB   1 
ATOM   2034 S SG   . CYS A 1 146 ? -13.67031 14.36939  -12.37944 1.000 25.43263 ? 326 CYS A SG   1 
ATOM   2035 H H    . CYS A 1 146 ? -14.78638 11.86089  -8.98483  1.000 23.25798 ? 326 CYS A H    1 
ATOM   2036 H HA   . CYS A 1 146 ? -15.63692 14.14297  -10.21118 1.000 20.57015 ? 326 CYS A HA   1 
ATOM   2037 H HB2  . CYS A 1 146 ? -13.31162 14.18505  -10.12935 1.000 31.89389 ? 326 CYS A HB2  1 
ATOM   2038 H HB3  . CYS A 1 146 ? -13.25867 12.75302  -10.81629 1.000 31.89389 ? 326 CYS A HB3  1 
ATOM   2039 H HG   . CYS A 1 146 ? -12.52319 14.58984  -12.65423 1.000 30.97121 ? 326 CYS A HG   1 
ATOM   2040 N N    . ILE A 1 147 ? -16.94109 12.92877  -11.87065 1.000 20.64167 ? 327 ILE A N    1 
ATOM   2041 C CA   . ILE A 1 147 ? -17.82818 12.15594  -12.73316 1.000 22.72797 ? 327 ILE A CA   1 
ATOM   2042 C C    . ILE A 1 147 ? -17.96842 12.86400  -14.07283 1.000 23.72933 ? 327 ILE A C    1 
ATOM   2043 O O    . ILE A 1 147 ? -18.13753 14.08591  -14.12505 1.000 22.95727 ? 327 ILE A O    1 
ATOM   2044 C CB   . ILE A 1 147 ? -19.21832 11.95473  -12.09092 1.000 22.89353 ? 327 ILE A CB   1 
ATOM   2045 C CG1  . ILE A 1 147 ? -19.07902 11.43560  -10.65841 1.000 24.50106 ? 327 ILE A CG1  1 
ATOM   2046 C CG2  . ILE A 1 147 ? -20.05666 10.99524  -12.92820 1.000 23.77380 ? 327 ILE A CG2  1 
ATOM   2047 C CD1  . ILE A 1 147 ? -20.39987 11.26829  -9.93668  1.000 25.10718 ? 327 ILE A CD1  1 
ATOM   2048 H H    . ILE A 1 147 ? -17.15468 13.76017  -11.81806 1.000 22.50976 ? 327 ILE A H    1 
ATOM   2049 H HA   . ILE A 1 147 ? -17.42690 11.28668  -12.88891 1.000 27.72561 ? 327 ILE A HA   1 
ATOM   2050 H HB   . ILE A 1 147 ? -19.66715 12.81415  -12.06185 1.000 25.21199 ? 327 ILE A HB   1 
ATOM   2051 H HG12 . ILE A 1 147 ? -18.64316 10.56936  -10.68197 1.000 29.85332 ? 327 ILE A HG12 1 
ATOM   2052 H HG13 . ILE A 1 147 ? -18.54193 12.06353  -10.15034 1.000 29.85332 ? 327 ILE A HG13 1 
ATOM   2053 H HG21 . ILE A 1 147 ? -20.94426 10.93203  -12.54210 1.000 26.26832 ? 327 ILE A HG21 1 
ATOM   2054 H HG22 . ILE A 1 147 ? -20.11383 11.33472  -13.83505 1.000 26.26832 ? 327 ILE A HG22 1 
ATOM   2055 H HG23 . ILE A 1 147 ? -19.63284 10.12272  -12.92774 1.000 26.26832 ? 327 ILE A HG23 1 
ATOM   2056 H HD11 . ILE A 1 147 ? -20.22803 11.12405  -8.99298  1.000 30.58066 ? 327 ILE A HD11 1 
ATOM   2057 H HD12 . ILE A 1 147 ? -20.92969 12.07179  -10.05739 1.000 30.58066 ? 327 ILE A HD12 1 
ATOM   2058 H HD13 . ILE A 1 147 ? -20.86818 10.50436  -10.30817 1.000 30.58066 ? 327 ILE A HD13 1 
ATOM   2059 N N    . TYR A 1 148 ? -17.90782 12.09440  -15.15624 1.000 21.67373 ? 328 TYR A N    1 
ATOM   2060 C CA   . TYR A 1 148 ? -18.15698 12.59817  -16.50096 1.000 22.06739 ? 328 TYR A CA   1 
ATOM   2061 C C    . TYR A 1 148 ? -19.37674 11.89114  -17.07462 1.000 28.02912 ? 328 TYR A C    1 
ATOM   2062 O O    . TYR A 1 148 ? -19.41846 10.65733  -17.11891 1.000 29.26377 ? 328 TYR A O    1 
ATOM   2063 C CB   . TYR A 1 148 ? -16.93891 12.38309  -17.40485 1.000 26.33238 ? 328 TYR A CB   1 
ATOM   2064 C CG   . TYR A 1 148 ? -17.11628 12.89706  -18.81754 1.000 21.40243 ? 328 TYR A CG   1 
ATOM   2065 C CD1  . TYR A 1 148 ? -17.03909 14.25394  -19.09878 1.000 21.75391 ? 328 TYR A CD1  1 
ATOM   2066 C CD2  . TYR A 1 148 ? -17.35112 12.02309  -19.87013 1.000 23.84624 ? 328 TYR A CD2  1 
ATOM   2067 C CE1  . TYR A 1 148 ? -17.19725 14.72741  -20.38770 1.000 21.95535 ? 328 TYR A CE1  1 
ATOM   2068 C CE2  . TYR A 1 148 ? -17.51072 12.48643  -21.16220 1.000 26.05741 ? 328 TYR A CE2  1 
ATOM   2069 C CZ   . TYR A 1 148 ? -17.43159 13.83822  -21.41548 1.000 22.87189 ? 328 TYR A CZ   1 
ATOM   2070 O OH   . TYR A 1 148 ? -17.59002 14.30271  -22.70002 1.000 25.54829 ? 328 TYR A OH   1 
ATOM   2071 H H    . TYR A 1 148 ? -17.71922 11.25559  -15.13541 1.000 24.47630 ? 328 TYR A H    1 
ATOM   2072 H HA   . TYR A 1 148 ? -18.34162 13.54982  -16.46659 1.000 26.46430 ? 328 TYR A HA   1 
ATOM   2073 H HB2  . TYR A 1 148 ? -16.17933 12.84506  -17.01688 1.000 32.05090 ? 328 TYR A HB2  1 
ATOM   2074 H HB3  . TYR A 1 148 ? -16.75662 11.43188  -17.45855 1.000 32.05090 ? 328 TYR A HB3  1 
ATOM   2075 H HD1  . TYR A 1 148 ? -16.87811 14.85522  -18.40781 1.000 26.55674 ? 328 TYR A HD1  1 
ATOM   2076 H HD2  . TYR A 1 148 ? -17.40195 11.10968  -19.70282 1.000 29.06754 ? 328 TYR A HD2  1 
ATOM   2077 H HE1  . TYR A 1 148 ? -17.14596 15.63974  -20.56073 1.000 24.08618 ? 328 TYR A HE1  1 
ATOM   2078 H HE2  . TYR A 1 148 ? -17.67064 11.88907  -21.85682 1.000 31.72094 ? 328 TYR A HE2  1 
ATOM   2079 H HH   . TYR A 1 148 ? -17.52706 15.14026  -22.71247 1.000 31.11000 ? 328 TYR A HH   1 
ATOM   2080 N N    . TYR A 1 149 ? -20.36275 12.67096  -17.51116 1.000 28.20920 ? 329 TYR A N    1 
ATOM   2081 C CA   . TYR A 1 149 ? -21.58762 12.14151  -18.09534 1.000 25.84262 ? 329 TYR A CA   1 
ATOM   2082 C C    . TYR A 1 149 ? -21.53691 12.28470  -19.61108 1.000 26.89130 ? 329 TYR A C    1 
ATOM   2083 O O    . TYR A 1 149 ? -21.04886 13.29151  -20.13256 1.000 33.16661 ? 329 TYR A O    1 
ATOM   2084 C CB   . TYR A 1 149 ? -22.81541 12.86862  -17.54346 1.000 28.95264 ? 329 TYR A CB   1 
ATOM   2085 C CG   . TYR A 1 149 ? -22.95782 12.78585  -16.04063 1.000 27.66880 ? 329 TYR A CG   1 
ATOM   2086 C CD1  . TYR A 1 149 ? -23.50014 11.66023  -15.43433 1.000 27.73227 ? 329 TYR A CD1  1 
ATOM   2087 C CD2  . TYR A 1 149 ? -22.55396 13.83660  -15.22775 1.000 26.69987 ? 329 TYR A CD2  1 
ATOM   2088 C CE1  . TYR A 1 149 ? -23.63244 11.58271  -14.05994 1.000 27.82016 ? 329 TYR A CE1  1 
ATOM   2089 C CE2  . TYR A 1 149 ? -22.68327 13.76872  -13.85434 1.000 26.76886 ? 329 TYR A CE2  1 
ATOM   2090 C CZ   . TYR A 1 149 ? -23.22272 12.64014  -13.27569 1.000 27.33380 ? 329 TYR A CZ   1 
ATOM   2091 O OH   . TYR A 1 149 ? -23.35077 12.57321  -11.90779 1.000 27.48389 ? 329 TYR A OH   1 
ATOM   2092 H H    . TYR A 1 149 ? -20.34311 13.53009  -17.47800 1.000 34.30309 ? 329 TYR A H    1 
ATOM   2093 H HA   . TYR A 1 149 ? -21.67203 11.20025  -17.87667 1.000 29.59106 ? 329 TYR A HA   1 
ATOM   2094 H HB2  . TYR A 1 149 ? -22.75426 13.80674  -17.78242 1.000 35.19522 ? 329 TYR A HB2  1 
ATOM   2095 H HB3  . TYR A 1 149 ? -23.61101 12.47725  -17.93683 1.000 35.19522 ? 329 TYR A HB3  1 
ATOM   2096 H HD1  . TYR A 1 149 ? -23.77903 10.94659  -15.96145 1.000 31.01848 ? 329 TYR A HD1  1 
ATOM   2097 H HD2  . TYR A 1 149 ? -22.18988 14.59974  -15.61501 1.000 29.77960 ? 329 TYR A HD2  1 
ATOM   2098 H HE1  . TYR A 1 149 ? -23.99555 10.82199  -13.66705 1.000 31.12394 ? 329 TYR A HE1  1 
ATOM   2099 H HE2  . TYR A 1 149 ? -22.40788 14.48057  -13.32299 1.000 31.93855 ? 329 TYR A HE2  1 
ATOM   2100 H HH   . TYR A 1 149 ? -23.71894 11.85068  -11.68871 1.000 30.72042 ? 329 TYR A HH   1 
ATOM   2101 N N    . LEU A 1 150 ? -22.03690 11.27004  -20.31608 1.000 26.68548 ? 330 LEU A N    1 
ATOM   2102 C CA   . LEU A 1 150 ? -21.95556 11.22755  -21.77381 1.000 46.01343 ? 330 LEU A CA   1 
ATOM   2103 C C    . LEU A 1 150 ? -23.26025 10.71929  -22.37865 1.000 36.41237 ? 330 LEU A C    1 
ATOM   2104 O O    . LEU A 1 150 ? -23.25917 9.95580   -23.34964 1.000 47.82963 ? 330 LEU A O    1 
ATOM   2105 C CB   . LEU A 1 150 ? -20.76763 10.37562  -22.23465 1.000 33.51874 ? 330 LEU A CB   1 
ATOM   2106 C CG   . LEU A 1 150 ? -20.52681 8.95180   -21.70487 1.000 45.35245 ? 330 LEU A CG   1 
ATOM   2107 C CD1  . LEU A 1 150 ? -20.47329 8.88163   -20.17861 1.000 32.26599 ? 330 LEU A CD1  1 
ATOM   2108 C CD2  . LEU A 1 150 ? -21.56435 7.97706   -22.24401 1.000 31.85779 ? 330 LEU A CD2  1 
ATOM   2109 H H    . LEU A 1 150 ? -22.43112 10.58927  -19.96860 1.000 29.76233 ? 330 LEU A H    1 
ATOM   2110 H HA   . LEU A 1 150 ? -21.82293 12.13198  -22.09832 1.000 55.66816 ? 330 LEU A HA   1 
ATOM   2111 H HB2  . LEU A 1 150 ? -20.84742 10.28504  -23.19711 1.000 40.67454 ? 330 LEU A HB2  1 
ATOM   2112 H HB3  . LEU A 1 150 ? -19.96562 10.87450  -22.01374 1.000 40.67454 ? 330 LEU A HB3  1 
ATOM   2113 H HG   . LEU A 1 150 ? -19.65259 8.68144   -22.02667 1.000 54.87499 ? 330 LEU A HG   1 
ATOM   2114 H HD11 . LEU A 1 150 ? -19.96863 8.09594   -19.91610 1.000 39.17124 ? 330 LEU A HD11 1 
ATOM   2115 H HD12 . LEU A 1 150 ? -20.04019 9.68110   -19.84072 1.000 39.17124 ? 330 LEU A HD12 1 
ATOM   2116 H HD13 . LEU A 1 150 ? -21.37790 8.82437   -19.83320 1.000 39.17124 ? 330 LEU A HD13 1 
ATOM   2117 H HD21 . LEU A 1 150 ? -21.32677 7.07813   -21.96765 1.000 38.68140 ? 330 LEU A HD21 1 
ATOM   2118 H HD22 . LEU A 1 150 ? -22.43498 8.21346   -21.88761 1.000 38.68140 ? 330 LEU A HD22 1 
ATOM   2119 H HD23 . LEU A 1 150 ? -21.57703 8.03295   -23.21231 1.000 38.68140 ? 330 LEU A HD23 1 
ATOM   2120 N N    . ASN A 1 151 ? -24.39376 11.15743  -21.83220 1.000 36.13932 ? 331 ASN A N    1 
ATOM   2121 C CA   . ASN A 1 151 ? -25.71191 10.73407  -22.30782 1.000 31.41056 ? 331 ASN A CA   1 
ATOM   2122 C C    . ASN A 1 151 ? -26.27989 11.82153  -23.21513 1.000 42.42380 ? 331 ASN A C    1 
ATOM   2123 O O    . ASN A 1 151 ? -26.92223 12.76817  -22.75807 1.000 33.08738 ? 331 ASN A O    1 
ATOM   2124 C CB   . ASN A 1 151 ? -26.64316 10.44774  -21.13602 1.000 32.32107 ? 331 ASN A CB   1 
ATOM   2125 C CG   . ASN A 1 151 ? -26.04428 9.47816   -20.14245 1.000 31.40074 ? 331 ASN A CG   1 
ATOM   2126 O OD1  . ASN A 1 151 ? -26.01204 8.27046   -20.37766 1.000 33.21293 ? 331 ASN A OD1  1 
ATOM   2127 N ND2  . ASN A 1 151 ? -25.56217 10.00258  -19.02336 1.000 30.60979 ? 331 ASN A ND2  1 
ATOM   2128 H H    . ASN A 1 151 ? -24.42614 11.70968  -21.17375 1.000 43.81924 ? 331 ASN A H    1 
ATOM   2129 H HA   . ASN A 1 151 ? -25.60482 9.92642   -22.83426 1.000 36.47316 ? 331 ASN A HA   1 
ATOM   2130 H HB2  . ASN A 1 151 ? -26.83104 11.27772  -20.67049 1.000 36.52504 ? 331 ASN A HB2  1 
ATOM   2131 H HB3  . ASN A 1 151 ? -27.46715 10.06248  -21.47296 1.000 36.52504 ? 331 ASN A HB3  1 
ATOM   2132 H HD21 . ASN A 1 151 ? -25.21094 9.49307   -18.42618 1.000 34.47150 ? 331 ASN A HD21 1 
ATOM   2133 H HD22 . ASN A 1 151 ? -25.60086 10.85208  -18.89506 1.000 34.47150 ? 331 ASN A HD22 1 
ATOM   2134 N N    . LYS A 1 152 ? -26.04106 11.67933  -24.51589 1.000 32.41290 ? 332 LYS A N    1 
ATOM   2135 C CA   . LYS A 1 152 ? -26.64361 12.58258  -25.48520 1.000 42.92634 ? 332 LYS A CA   1 
ATOM   2136 C C    . LYS A 1 152 ? -28.12596 12.26630  -25.64292 1.000 53.91399 ? 332 LYS A C    1 
ATOM   2137 O O    . LYS A 1 152 ? -28.53441 11.10175  -25.62681 1.000 52.50453 ? 332 LYS A O    1 
ATOM   2138 C CB   . LYS A 1 152 ? -25.93272 12.47134  -26.83316 1.000 33.06292 ? 332 LYS A CB   1 
ATOM   2139 C CG   . LYS A 1 152 ? -26.20332 13.63624  -27.77129 1.000 42.23421 ? 332 LYS A CG   1 
ATOM   2140 H H    . LYS A 1 152 ? -25.53758 11.07224  -24.85874 1.000 36.63523 ? 332 LYS A H    1 
ATOM   2141 H HA   . LYS A 1 152 ? -26.55427 13.49815  -25.17755 1.000 51.96366 ? 332 LYS A HA   1 
ATOM   2142 H HB2  . LYS A 1 152 ? -24.97596 12.43316  -26.67804 1.000 38.57662 ? 332 LYS A HB2  1 
ATOM   2143 H HB3  . LYS A 1 152 ? -26.22970 11.66077  -27.27550 1.000 38.57662 ? 332 LYS A HB3  1 
ATOM   2144 N N    . ASP A 1 153 ? -28.93271 13.31661  -25.79159 1.000 55.42012 ? 333 ASP A N    1 
ATOM   2145 C CA   . ASP A 1 153 ? -30.38175 13.21782  -25.93784 1.000 51.42199 ? 333 ASP A CA   1 
ATOM   2146 C C    . ASP A 1 153 ? -31.07949 12.81576  -24.64433 1.000 39.11968 ? 333 ASP A C    1 
ATOM   2147 O O    . ASP A 1 153 ? -32.24885 12.41922  -24.67081 1.000 41.69142 ? 333 ASP A O    1 
ATOM   2148 C CB   . ASP A 1 153 ? -30.76617 12.23482  -27.05078 1.000 46.94838 ? 333 ASP A CB   1 
ATOM   2149 C CG   . ASP A 1 153 ? -30.00945 12.48670  -28.33830 1.000 54.27418 ? 333 ASP A CG   1 
ATOM   2150 O OD1  . ASP A 1 153 ? -30.30480 11.80858  -29.34462 1.000 67.49812 ? 333 ASP A OD1  1 
ATOM   2151 O OD2  . ASP A 1 153 ? -29.11881 13.36206  -28.34345 1.000 66.30739 ? 333 ASP A OD2  1 
ATOM   2152 H H    . ASP A 1 153 ? -28.65020 14.12865  -25.81131 1.000 66.95620 ? 333 ASP A H    1 
ATOM   2153 H HA   . ASP A 1 153 ? -30.70999 14.09717  -26.18258 1.000 62.15843 ? 333 ASP A HA   1 
ATOM   2154 H HB2  . ASP A 1 153 ? -30.56810 11.33162  -26.75769 1.000 56.79011 ? 333 ASP A HB2  1 
ATOM   2155 H HB3  . ASP A 1 153 ? -31.71400 12.32273  -27.23728 1.000 56.79011 ? 333 ASP A HB3  1 
ATOM   2156 N N    . TRP A 1 154 ? -30.39292 12.90387  -23.50762 1.000 37.86376 ? 334 TRP A N    1 
ATOM   2157 C CA   . TRP A 1 154 ? -31.02494 12.59833  -22.23128 1.000 38.42176 ? 334 TRP A CA   1 
ATOM   2158 C C    . TRP A 1 154 ? -32.04706 13.67192  -21.87741 1.000 44.63888 ? 334 TRP A C    1 
ATOM   2159 O O    . TRP A 1 154 ? -31.75260 14.87009  -21.93620 1.000 41.70352 ? 334 TRP A O    1 
ATOM   2160 C CB   . TRP A 1 154 ? -29.97504 12.49105  -21.12617 1.000 45.10980 ? 334 TRP A CB   1 
ATOM   2161 C CG   . TRP A 1 154 ? -30.52419 11.94257  -19.84268 1.000 42.35679 ? 334 TRP A CG   1 
ATOM   2162 C CD1  . TRP A 1 154 ? -30.96023 12.65808  -18.76580 1.000 47.46560 ? 334 TRP A CD1  1 
ATOM   2163 C CD2  . TRP A 1 154 ? -30.69982 10.56167  -19.50378 1.000 39.35274 ? 334 TRP A CD2  1 
ATOM   2164 N NE1  . TRP A 1 154 ? -31.39620 11.80916  -17.77753 1.000 38.20033 ? 334 TRP A NE1  1 
ATOM   2165 C CE2  . TRP A 1 154 ? -31.24702 10.51663  -18.20582 1.000 41.78417 ? 334 TRP A CE2  1 
ATOM   2166 C CE3  . TRP A 1 154 ? -30.44768 9.35973   -20.17126 1.000 37.24055 ? 334 TRP A CE3  1 
ATOM   2167 C CZ2  . TRP A 1 154 ? -31.54523 9.31791   -17.56278 1.000 40.00953 ? 334 TRP A CZ2  1 
ATOM   2168 C CZ3  . TRP A 1 154 ? -30.74365 8.17112   -19.53031 1.000 39.87934 ? 334 TRP A CZ3  1 
ATOM   2169 C CH2  . TRP A 1 154 ? -31.28950 8.15929   -18.24099 1.000 38.69697 ? 334 TRP A CH2  1 
ATOM   2170 H H    . TRP A 1 154 ? -29.56696 13.13646  -23.45029 1.000 43.17627 ? 334 TRP A H    1 
ATOM   2171 H HA   . TRP A 1 154 ? -31.48247 11.74578  -22.30001 1.000 43.84587 ? 334 TRP A HA   1 
ATOM   2172 H HB2  . TRP A 1 154 ? -29.26491 11.90094  -21.42347 1.000 54.58381 ? 334 TRP A HB2  1 
ATOM   2173 H HB3  . TRP A 1 154 ? -29.61810 13.37457  -20.94486 1.000 54.58381 ? 334 TRP A HB3  1 
ATOM   2174 H HD1  . TRP A 1 154 ? -30.96205 13.58634  -18.70902 1.000 57.41076 ? 334 TRP A HD1  1 
ATOM   2175 H HE1  . TRP A 1 154 ? -31.71136 12.04997  -17.01445 1.000 45.75065 ? 334 TRP A HE1  1 
ATOM   2176 H HE3  . TRP A 1 154 ? -30.08819 9.35961   -21.02897 1.000 42.42841 ? 334 TRP A HE3  1 
ATOM   2177 H HZ2  . TRP A 1 154 ? -31.90449 9.30627   -16.70505 1.000 48.46349 ? 334 TRP A HZ2  1 
ATOM   2178 H HZ3  . TRP A 1 154 ? -30.57722 7.36503   -19.96322 1.000 48.30725 ? 334 TRP A HZ3  1 
ATOM   2179 H HH2  . TRP A 1 154 ? -31.48249 7.34424   -17.83683 1.000 46.88841 ? 334 TRP A HH2  1 
ATOM   2180 N N    . ASP A 1 155 ? -33.24933 13.23884  -21.50696 1.000 43.02961 ? 335 ASP A N    1 
ATOM   2181 C CA   . ASP A 1 155 ? -34.31466 14.12588  -21.04346 1.000 43.02233 ? 335 ASP A CA   1 
ATOM   2182 C C    . ASP A 1 155 ? -34.69391 13.65739  -19.64185 1.000 48.88944 ? 335 ASP A C    1 
ATOM   2183 O O    . ASP A 1 155 ? -35.39362 12.65197  -19.48231 1.000 44.36586 ? 335 ASP A O    1 
ATOM   2184 C CB   . ASP A 1 155 ? -35.50648 14.10516  -21.99591 1.000 45.03033 ? 335 ASP A CB   1 
ATOM   2185 C CG   . ASP A 1 155 ? -36.65868 14.96417  -21.50925 1.000 46.77989 ? 335 ASP A CG   1 
ATOM   2186 O OD1  . ASP A 1 155 ? -36.47965 15.70040  -20.51681 1.000 46.36347 ? 335 ASP A OD1  1 
ATOM   2187 O OD2  . ASP A 1 155 ? -37.74629 14.90020  -22.11955 1.000 48.63831 ? 335 ASP A OD2  1 
ATOM   2188 H H    . ASP A 1 155 ? -33.47890 12.41009  -21.51562 1.000 52.08758 ? 335 ASP A H    1 
ATOM   2189 H HA   . ASP A 1 155 ? -33.99500 15.04052  -20.99714 1.000 49.36655 ? 335 ASP A HA   1 
ATOM   2190 H HB2  . ASP A 1 155 ? -35.22583 14.44140  -22.86140 1.000 51.77615 ? 335 ASP A HB2  1 
ATOM   2191 H HB3  . ASP A 1 155 ? -35.82691 13.19368  -22.08211 1.000 51.77615 ? 335 ASP A HB3  1 
ATOM   2192 N N    . ALA A 1 156 ? -34.22927 14.39144  -18.62862 1.000 42.51949 ? 336 ALA A N    1 
ATOM   2193 C CA   . ALA A 1 156 ? -34.37050 13.93350  -17.25008 1.000 50.48755 ? 336 ALA A CA   1 
ATOM   2194 C C    . ALA A 1 156 ? -35.83135 13.86267  -16.82434 1.000 46.14559 ? 336 ALA A C    1 
ATOM   2195 O O    . ALA A 1 156 ? -36.22089 12.95859  -16.07563 1.000 45.32723 ? 336 ALA A O    1 
ATOM   2196 C CB   . ALA A 1 156 ? -33.58827 14.85355  -16.31589 1.000 46.93856 ? 336 ALA A CB   1 
ATOM   2197 H H    . ALA A 1 156 ? -33.83279 15.14993  -18.71283 1.000 48.76314 ? 336 ALA A H    1 
ATOM   2198 H HA   . ALA A 1 156 ? -34.00010 13.03949  -17.18339 1.000 61.03711 ? 336 ALA A HA   1 
ATOM   2199 H HB1  . ALA A 1 156 ? -33.68806 14.53700  -15.40444 1.000 56.77832 ? 336 ALA A HB1  1 
ATOM   2200 H HB2  . ALA A 1 156 ? -32.65228 14.83999  -16.57015 1.000 56.77832 ? 336 ALA A HB2  1 
ATOM   2201 H HB3  . ALA A 1 156 ? -33.93907 15.75456  -16.39339 1.000 56.77832 ? 336 ALA A HB3  1 
ATOM   2202 N N    . LYS A 1 157 ? -36.65365 14.80879  -17.28089 1.000 48.15090 ? 337 LYS A N    1 
ATOM   2203 C CA   . LYS A 1 157 ? -38.04429 14.85196  -16.84564 1.000 51.88036 ? 337 LYS A CA   1 
ATOM   2204 C C    . LYS A 1 157 ? -38.80036 13.57639  -17.19217 1.000 49.59962 ? 337 LYS A C    1 
ATOM   2205 O O    . LYS A 1 157 ? -39.81751 13.28209  -16.55451 1.000 56.81652 ? 337 LYS A O    1 
ATOM   2206 C CB   . LYS A 1 157 ? -38.74811 16.05717  -17.46865 1.000 49.63656 ? 337 LYS A CB   1 
ATOM   2207 C CG   . LYS A 1 157 ? -38.42057 17.38188  -16.79877 1.000 55.64354 ? 337 LYS A CG   1 
ATOM   2208 C CD   . LYS A 1 157 ? -39.46450 17.75197  -15.75689 1.000 62.90461 ? 337 LYS A CD   1 
ATOM   2209 H H    . LYS A 1 157 ? -36.43216 15.42764  -17.83547 1.000 58.23312 ? 337 LYS A H    1 
ATOM   2210 H HA   . LYS A 1 157 ? -38.06319 14.95483  -15.88129 1.000 62.70848 ? 337 LYS A HA   1 
ATOM   2211 H HB2  . LYS A 1 157 ? -38.48350 16.12427  -18.39944 1.000 57.30363 ? 337 LYS A HB2  1 
ATOM   2212 H HB3  . LYS A 1 157 ? -39.70681 15.92391  -17.40507 1.000 57.30363 ? 337 LYS A HB3  1 
ATOM   2213 H HG2  . LYS A 1 157 ? -37.55954 17.31450  -16.35719 1.000 67.22429 ? 337 LYS A HG2  1 
ATOM   2214 H HG3  . LYS A 1 157 ? -38.39601 18.08324  -17.46839 1.000 67.22429 ? 337 LYS A HG3  1 
ATOM   2215 N N    . VAL A 1 158 ? -38.33553 12.81808  -18.18173 1.000 56.64104 ? 338 VAL A N    1 
ATOM   2216 C CA   . VAL A 1 158 ? -38.95886 11.56181  -18.57930 1.000 51.37234 ? 338 VAL A CA   1 
ATOM   2217 C C    . VAL A 1 158 ? -38.11143 10.36467  -18.16021 1.000 48.60880 ? 338 VAL A C    1 
ATOM   2218 O O    . VAL A 1 158 ? -38.62976 9.38358   -17.62590 1.000 49.48967 ? 338 VAL A O    1 
ATOM   2219 C CB   . VAL A 1 158 ? -39.23760 11.53585  -20.10051 1.000 50.66871 ? 338 VAL A CB   1 
ATOM   2220 C CG1  . VAL A 1 158 ? -40.32059 12.54018  -20.45848 1.000 52.54325 ? 338 VAL A CG1  1 
ATOM   2221 C CG2  . VAL A 1 158 ? -37.96703 11.80407  -20.89840 1.000 48.68458 ? 338 VAL A CG2  1 
ATOM   2222 H H    . VAL A 1 158 ? -37.64160 13.01729  -18.64903 1.000 68.42129 ? 338 VAL A H    1 
ATOM   2223 H HA   . VAL A 1 158 ? -39.81188 11.48954  -18.12319 1.000 62.09886 ? 338 VAL A HA   1 
ATOM   2224 H HB   . VAL A 1 158 ? -39.55150 10.64994  -20.34037 1.000 58.54221 ? 338 VAL A HB   1 
ATOM   2225 H HG11 . VAL A 1 158 ? -40.47797 12.50740  -21.41506 1.000 61.17442 ? 338 VAL A HG11 1 
ATOM   2226 H HG12 . VAL A 1 158 ? -41.13361 12.31139  -19.98145 1.000 61.17442 ? 338 VAL A HG12 1 
ATOM   2227 H HG13 . VAL A 1 158 ? -40.02530 13.42785  -20.20206 1.000 61.17442 ? 338 VAL A HG13 1 
ATOM   2228 H HG21 . VAL A 1 158 ? -38.18015 11.79328  -21.84464 1.000 56.16125 ? 338 VAL A HG21 1 
ATOM   2229 H HG22 . VAL A 1 158 ? -37.61469 12.67260  -20.64859 1.000 56.16125 ? 338 VAL A HG22 1 
ATOM   2230 H HG23 . VAL A 1 158 ? -37.31647 11.11307  -20.69796 1.000 56.16125 ? 338 VAL A HG23 1 
ATOM   2231 N N    . SER A 1 159 ? -36.80087 10.43154  -18.39314 1.000 53.60620 ? 339 SER A N    1 
ATOM   2232 C CA   . SER A 1 159 ? -35.90596 9.31713   -18.11314 1.000 45.10660 ? 339 SER A CA   1 
ATOM   2233 C C    . SER A 1 159 ? -35.34774 9.33178   -16.69615 1.000 44.11773 ? 339 SER A C    1 
ATOM   2234 O O    . SER A 1 159 ? -34.70659 8.35529   -16.29266 1.000 43.17979 ? 339 SER A O    1 
ATOM   2235 C CB   . SER A 1 159 ? -34.74291 9.31615   -19.11170 1.000 43.39994 ? 339 SER A CB   1 
ATOM   2236 O OG   . SER A 1 159 ? -35.21803 9.32992   -20.44643 1.000 49.17669 ? 339 SER A OG   1 
ATOM   2237 H H    . SER A 1 159 ? -36.40362 11.12195  -18.71738 1.000 64.77949 ? 339 SER A H    1 
ATOM   2238 H HA   . SER A 1 159 ? -36.40199 8.49097   -18.22409 1.000 51.86768 ? 339 SER A HA   1 
ATOM   2239 H HB2  . SER A 1 159 ? -34.19930 10.10559  -18.96276 1.000 49.81969 ? 339 SER A HB2  1 
ATOM   2240 H HB3  . SER A 1 159 ? -34.21111 8.51653   -18.97496 1.000 49.81969 ? 339 SER A HB3  1 
ATOM   2241 H HG   . SER A 1 159 ? -34.57075 9.33064   -20.98180 1.000 59.46408 ? 339 SER A HG   1 
ATOM   2242 N N    . GLY A 1 160 ? -35.57361 10.39942  -15.93549 1.000 44.36452 ? 340 GLY A N    1 
ATOM   2243 C CA   . GLY A 1 160 ? -35.06133 10.44680  -14.57701 1.000 45.38480 ? 340 GLY A CA   1 
ATOM   2244 C C    . GLY A 1 160 ? -33.54939 10.36326  -14.54904 1.000 41.96891 ? 340 GLY A C    1 
ATOM   2245 O O    . GLY A 1 160 ? -32.85081 10.95430  -15.38005 1.000 49.40418 ? 340 GLY A O    1 
ATOM   2246 H H    . GLY A 1 160 ? -36.01345 11.09685  -16.17990 1.000 52.86692 ? 340 GLY A H    1 
ATOM   2247 H HA2  . GLY A 1 160 ? -35.33260 11.27784  -14.15666 1.000 54.91381 ? 340 GLY A HA2  1 
ATOM   2248 H HA3  . GLY A 1 160 ? -35.42123 9.70342   -14.06832 1.000 54.91381 ? 340 GLY A HA3  1 
ATOM   2249 N N    . GLY A 1 161 ? -33.03082 9.61815   -13.57530 1.000 46.16335 ? 341 GLY A N    1 
ATOM   2250 C CA   . GLY A 1 161 ? -31.59795 9.43931   -13.45831 1.000 38.73357 ? 341 GLY A CA   1 
ATOM   2251 C C    . GLY A 1 161 ? -30.85076 10.63431  -12.91633 1.000 45.47280 ? 341 GLY A C    1 
ATOM   2252 O O    . GLY A 1 161 ? -29.64242 10.74786  -13.13678 1.000 46.71628 ? 341 GLY A O    1 
ATOM   2253 H H    . GLY A 1 161 ? -33.49008 9.20900   -12.97424 1.000 55.84806 ? 341 GLY A H    1 
ATOM   2254 H HA2  . GLY A 1 161 ? -31.42574 8.68989   -12.86703 1.000 46.93233 ? 341 GLY A HA2  1 
ATOM   2255 H HA3  . GLY A 1 161 ? -31.23734 9.23837   -14.33609 1.000 46.93233 ? 341 GLY A HA3  1 
ATOM   2256 N N    . ILE A 1 162 ? -31.53445 11.53563  -12.21057 1.000 39.07136 ? 342 ILE A N    1 
ATOM   2257 C CA   . ILE A 1 162 ? -30.87194 12.70804  -11.65615 1.000 45.86624 ? 342 ILE A CA   1 
ATOM   2258 C C    . ILE A 1 162 ? -30.03309 12.30160  -10.45326 1.000 46.52935 ? 342 ILE A C    1 
ATOM   2259 O O    . ILE A 1 162 ? -30.45257 11.48061  -9.62557  1.000 36.83273 ? 342 ILE A O    1 
ATOM   2260 C CB   . ILE A 1 162 ? -31.90524 13.77936  -11.26707 1.000 51.21307 ? 342 ILE A CB   1 
ATOM   2261 C CG1  . ILE A 1 162 ? -32.46902 14.45878  -12.51672 1.000 50.12359 ? 342 ILE A CG1  1 
ATOM   2262 C CG2  . ILE A 1 162 ? -31.27868 14.81003  -10.33252 1.000 40.30377 ? 342 ILE A CG2  1 
ATOM   2263 C CD1  . ILE A 1 162 ? -33.73390 15.25615  -12.25986 1.000 44.24701 ? 342 ILE A CD1  1 
ATOM   2264 H H    . ILE A 1 162 ? -32.37636 11.48929  -12.04135 1.000 47.33768 ? 342 ILE A H    1 
ATOM   2265 H HA   . ILE A 1 162 ? -30.28474 13.08263  -12.33127 1.000 55.49154 ? 342 ILE A HA   1 
ATOM   2266 H HB   . ILE A 1 162 ? -32.63521 13.34337  -10.80021 1.000 61.90774 ? 342 ILE A HB   1 
ATOM   2267 H HG12 . ILE A 1 162 ? -31.80127 15.06790  -12.86883 1.000 60.60036 ? 342 ILE A HG12 1 
ATOM   2268 H HG13 . ILE A 1 162 ? -32.67688 13.77763  -13.17531 1.000 60.60036 ? 342 ILE A HG13 1 
ATOM   2269 H HG21 . ILE A 1 162 ? -31.83148 15.60707  -10.32531 1.000 48.81657 ? 342 ILE A HG21 1 
ATOM   2270 H HG22 . ILE A 1 162 ? -31.22632 14.43571  -9.43919  1.000 48.81657 ? 342 ILE A HG22 1 
ATOM   2271 H HG23 . ILE A 1 162 ? -30.38923 15.02726  -10.65280 1.000 48.81657 ? 342 ILE A HG23 1 
ATOM   2272 H HD11 . ILE A 1 162 ? -34.10972 15.53459  -13.10964 1.000 53.54846 ? 342 ILE A HD11 1 
ATOM   2273 H HD12 . ILE A 1 162 ? -34.36854 14.69722  -11.78475 1.000 53.54846 ? 342 ILE A HD12 1 
ATOM   2274 H HD13 . ILE A 1 162 ? -33.51331 16.03457  -11.72478 1.000 53.54846 ? 342 ILE A HD13 1 
ATOM   2275 N N    . LEU A 1 163 ? -28.83551 12.87281  -10.35313 1.000 40.63546 ? 343 LEU A N    1 
ATOM   2276 C CA   . LEU A 1 163 ? -28.00110 12.72158  -9.16633  1.000 39.25840 ? 343 LEU A CA   1 
ATOM   2277 C C    . LEU A 1 163 ? -28.36851 13.83947  -8.19784  1.000 43.09744 ? 343 LEU A C    1 
ATOM   2278 O O    . LEU A 1 163 ? -28.03885 15.00598  -8.43209  1.000 40.04496 ? 343 LEU A O    1 
ATOM   2279 C CB   . LEU A 1 163 ? -26.51906 12.76547  -9.53036  1.000 38.98468 ? 343 LEU A CB   1 
ATOM   2280 C CG   . LEU A 1 163 ? -25.53171 12.91779  -8.36826  1.000 38.83854 ? 343 LEU A CG   1 
ATOM   2281 C CD1  . LEU A 1 163 ? -25.46798 11.64051  -7.54421  1.000 38.42122 ? 343 LEU A CD1  1 
ATOM   2282 C CD2  . LEU A 1 163 ? -24.15028 13.29288  -8.88232  1.000 38.89769 ? 343 LEU A CD2  1 
ATOM   2283 H H    . LEU A 1 163 ? -28.48074 13.35875  -10.96763 1.000 49.21461 ? 343 LEU A H    1 
ATOM   2284 H HA   . LEU A 1 163 ? -28.17525 11.86498  -8.74583  1.000 45.16558 ? 343 LEU A HA   1 
ATOM   2285 H HB2  . LEU A 1 163 ? -26.29727 11.93824  -9.98579  1.000 44.52137 ? 343 LEU A HB2  1 
ATOM   2286 H HB3  . LEU A 1 163 ? -26.37812 13.51928  -10.12433 1.000 44.52137 ? 343 LEU A HB3  1 
ATOM   2287 H HG   . LEU A 1 163 ? -25.84007 13.63207  -7.78893  1.000 46.52661 ? 343 LEU A HG   1 
ATOM   2288 H HD11 . LEU A 1 163 ? -24.81944 11.75608  -6.83221  1.000 43.84522 ? 343 LEU A HD11 1 
ATOM   2289 H HD12 . LEU A 1 163 ? -26.34429 11.46342  -7.16789  1.000 43.84522 ? 343 LEU A HD12 1 
ATOM   2290 H HD13 . LEU A 1 163 ? -25.20052 10.90664  -8.11936  1.000 43.84522 ? 343 LEU A HD13 1 
ATOM   2291 H HD21 . LEU A 1 163 ? -23.55382 13.41220  -8.12674  1.000 44.41698 ? 343 LEU A HD21 1 
ATOM   2292 H HD22 . LEU A 1 163 ? -23.82197 12.58113  -9.45374  1.000 44.41698 ? 343 LEU A HD22 1 
ATOM   2293 H HD23 . LEU A 1 163 ? -24.21456 14.11895  -9.38667  1.000 44.41698 ? 343 LEU A HD23 1 
ATOM   2294 N N    . ARG A 1 164 ? -29.06283 13.49260  -7.12106  1.000 39.74551 ? 344 ARG A N    1 
ATOM   2295 C CA   . ARG A 1 164 ? -29.45545 14.46633  -6.11259  1.000 40.20360 ? 344 ARG A CA   1 
ATOM   2296 C C    . ARG A 1 164 ? -28.45112 14.41280  -4.96993  1.000 43.22183 ? 344 ARG A C    1 
ATOM   2297 O O    . ARG A 1 164 ? -28.28935 13.36834  -4.32989  1.000 39.77699 ? 344 ARG A O    1 
ATOM   2298 C CB   . ARG A 1 164 ? -30.87028 14.20007  -5.60166  1.000 51.58320 ? 344 ARG A CB   1 
ATOM   2299 C CG   . ARG A 1 164 ? -31.29585 15.14385  -4.48922  1.000 43.00612 ? 344 ARG A CG   1 
ATOM   2300 C CD   . ARG A 1 164 ? -32.80551 15.17437  -4.32099  1.000 41.91590 ? 344 ARG A CD   1 
ATOM   2301 N NE   . ARG A 1 164 ? -33.45844 15.90728  -5.39925  1.000 44.41916 ? 344 ARG A NE   1 
ATOM   2302 C CZ   . ARG A 1 164 ? -34.76758 16.09764  -5.49350  1.000 52.75256 ? 344 ARG A CZ   1 
ATOM   2303 N NH1  . ARG A 1 164 ? -35.60231 15.63283  -4.57832  1.000 43.34047 ? 344 ARG A NH1  1 
ATOM   2304 N NH2  . ARG A 1 164 ? -35.25113 16.77634  -6.52988  1.000 49.43056 ? 344 ARG A NH2  1 
ATOM   2305 H H    . ARG A 1 164 ? -29.32068 12.68991  -6.95134  1.000 45.43437 ? 344 ARG A H    1 
ATOM   2306 H HA   . ARG A 1 164 ? -29.44347 15.35547  -6.50012  1.000 46.16462 ? 344 ARG A HA   1 
ATOM   2307 H HB2  . ARG A 1 164 ? -31.49411 14.30562  -6.33691  1.000 62.35189 ? 344 ARG A HB2  1 
ATOM   2308 H HB3  . ARG A 1 164 ? -30.91384 13.29440  -5.25703  1.000 62.35189 ? 344 ARG A HB3  1 
ATOM   2309 H HG2  . ARG A 1 164 ? -30.90313 14.84991  -3.65240  1.000 52.05939 ? 344 ARG A HG2  1 
ATOM   2310 H HG3  . ARG A 1 164 ? -30.99567 16.04202  -4.69916  1.000 52.05939 ? 344 ARG A HG3  1 
ATOM   2311 H HD2  . ARG A 1 164 ? -33.14560 14.26594  -4.32234  1.000 50.75112 ? 344 ARG A HD2  1 
ATOM   2312 H HD3  . ARG A 1 164 ? -33.02482 15.60947  -3.48225  1.000 50.75112 ? 344 ARG A HD3  1 
ATOM   2313 H HE   . ARG A 1 164 ? -32.96021 16.23905  -6.01675  1.000 53.75504 ? 344 ARG A HE   1 
ATOM   2314 H HH11 . ARG A 1 164 ? -36.44778 15.76783  -4.65927  1.000 49.74832 ? 344 ARG A HH11 1 
ATOM   2315 H HH12 . ARG A 1 164 ? -35.29943 15.19568  -3.90247  1.000 49.74832 ? 344 ARG A HH12 1 
ATOM   2316 H HH21 . ARG A 1 164 ? -34.71668 17.08561  -7.12847  1.000 59.76872 ? 344 ARG A HH21 1 
ATOM   2317 H HH22 . ARG A 1 164 ? -36.09828 16.90597  -6.60150  1.000 59.76872 ? 344 ARG A HH22 1 
ATOM   2318 N N    . ILE A 1 165 ? -27.77711 15.53420  -4.72787  1.000 40.31343 ? 345 ILE A N    1 
ATOM   2319 C CA   . ILE A 1 165 ? -26.80209 15.67630  -3.65611  1.000 40.37715 ? 345 ILE A CA   1 
ATOM   2320 C C    . ILE A 1 165 ? -27.42019 16.54730  -2.57332  1.000 41.00928 ? 345 ILE A C    1 
ATOM   2321 O O    . ILE A 1 165 ? -28.04528 17.57282  -2.86846  1.000 41.47653 ? 345 ILE A O    1 
ATOM   2322 C CB   . ILE A 1 165 ? -25.48176 16.29305  -4.16012  1.000 40.45741 ? 345 ILE A CB   1 
ATOM   2323 C CG1  . ILE A 1 165 ? -24.99709 15.58051  -5.42569  1.000 39.97615 ? 345 ILE A CG1  1 
ATOM   2324 C CG2  . ILE A 1 165 ? -24.41661 16.22828  -3.07320  1.000 40.59387 ? 345 ILE A CG2  1 
ATOM   2325 C CD1  . ILE A 1 165 ? -23.78550 16.22967  -6.06407  1.000 40.26071 ? 345 ILE A CD1  1 
ATOM   2326 H H    . ILE A 1 165 ? -27.87313 16.25274  -5.19055  1.000 46.11587 ? 345 ILE A H    1 
ATOM   2327 H HA   . ILE A 1 165 ? -26.60192 14.80193  -3.28690  1.000 46.19234 ? 345 ILE A HA   1 
ATOM   2328 H HB   . ILE A 1 165 ? -25.64838 17.22311  -4.37950  1.000 46.28865 ? 345 ILE A HB   1 
ATOM   2329 H HG12 . ILE A 1 165 ? -24.75908 14.66804  -5.19840  1.000 47.46560 ? 345 ILE A HG12 1 
ATOM   2330 H HG13 . ILE A 1 165 ? -25.71373 15.58343  -6.07938  1.000 47.46560 ? 345 ILE A HG13 1 
ATOM   2331 H HG21 . ILE A 1 165 ? -23.61458 16.67235  -3.39013  1.000 46.45241 ? 345 ILE A HG21 1 
ATOM   2332 H HG22 . ILE A 1 165 ? -24.74913 16.67368  -2.27824  1.000 46.45241 ? 345 ILE A HG22 1 
ATOM   2333 H HG23 . ILE A 1 165 ? -24.22362 15.29853  -2.87516  1.000 46.45241 ? 345 ILE A HG23 1 
ATOM   2334 H HD11 . ILE A 1 165 ? -23.63192 15.82612  -6.93267  1.000 46.05261 ? 345 ILE A HD11 1 
ATOM   2335 H HD12 . ILE A 1 165 ? -23.95302 17.17968  -6.16566  1.000 46.05261 ? 345 ILE A HD12 1 
ATOM   2336 H HD13 . ILE A 1 165 ? -23.01419 16.08901  -5.49294  1.000 46.05261 ? 345 ILE A HD13 1 
ATOM   2337 N N    . PHE A 1 166 ? -27.23563 16.14362  -1.32294  1.000 41.13119 ? 346 PHE A N    1 
ATOM   2338 C CA   . PHE A 1 166 ? -27.77013 16.86670  -0.17952  1.000 41.81895 ? 346 PHE A CA   1 
ATOM   2339 C C    . PHE A 1 166 ? -26.61352 17.50165  0.58025   1.000 42.20577 ? 346 PHE A C    1 
ATOM   2340 O O    . PHE A 1 166 ? -26.25923 17.03737  1.67123   1.000 42.41110 ? 346 PHE A O    1 
ATOM   2341 C CB   . PHE A 1 166 ? -28.56078 15.92755  0.73264   1.000 41.95578 ? 346 PHE A CB   1 
ATOM   2342 C CG   . PHE A 1 166 ? -29.67729 15.20386  0.03629   1.000 41.76541 ? 346 PHE A CG   1 
ATOM   2343 C CD1  . PHE A 1 166 ? -30.89834 15.82388  -0.17047  1.000 42.22746 ? 346 PHE A CD1  1 
ATOM   2344 C CD2  . PHE A 1 166 ? -29.50665 13.90459  -0.41200  1.000 45.59124 ? 346 PHE A CD2  1 
ATOM   2345 C CE1  . PHE A 1 166 ? -31.92884 15.16184  -0.81163  1.000 45.54688 ? 346 PHE A CE1  1 
ATOM   2346 C CE2  . PHE A 1 166 ? -30.53331 13.23774  -1.05333  1.000 41.25308 ? 346 PHE A CE2  1 
ATOM   2347 C CZ   . PHE A 1 166 ? -31.74569 13.86800  -1.25409  1.000 49.25164 ? 346 PHE A CZ   1 
ATOM   2348 H H    . PHE A 1 166 ? -26.79435 15.43797  -1.10631  1.000 49.61270 ? 346 PHE A H    1 
ATOM   2349 H HA   . PHE A 1 166 ? -28.37475 17.56386  -0.47837  1.000 47.92250 ? 346 PHE A HA   1 
ATOM   2350 H HB2  . PHE A 1 166 ? -27.95560 15.26076  1.09326   1.000 48.08669 ? 346 PHE A HB2  1 
ATOM   2351 H HB3  . PHE A 1 166 ? -28.94941 16.44733  1.45353   1.000 48.08669 ? 346 PHE A HB3  1 
ATOM   2352 H HD1  . PHE A 1 166 ? -31.02662 16.69612  0.12557   1.000 48.41271 ? 346 PHE A HD1  1 
ATOM   2353 H HD2  . PHE A 1 166 ? -28.69193 13.47600  -0.27996  1.000 55.16153 ? 346 PHE A HD2  1 
ATOM   2354 H HE1  . PHE A 1 166 ? -32.74460 15.58819  -0.94453  1.000 55.10830 ? 346 PHE A HE1  1 
ATOM   2355 H HE2  . PHE A 1 166 ? -30.40786 12.36514  -1.34952  1.000 49.80023 ? 346 PHE A HE2  1 
ATOM   2356 H HZ   . PHE A 1 166 ? -32.43718 13.42117  -1.68664  1.000 59.55401 ? 346 PHE A HZ   1 
ATOM   2357 N N    . PRO A 1 167 ? -26.00055 18.55512  0.04213   1.000 45.94354 ? 347 PRO A N    1 
ATOM   2358 C CA   . PRO A 1 167 ? -24.83269 19.14326  0.71056   1.000 43.02540 ? 347 PRO A CA   1 
ATOM   2359 C C    . PRO A 1 167 ? -25.16675 19.55222  2.13718   1.000 43.74745 ? 347 PRO A C    1 
ATOM   2360 O O    . PRO A 1 167 ? -26.19872 20.17371  2.40067   1.000 44.56427 ? 347 PRO A O    1 
ATOM   2361 C CB   . PRO A 1 167 ? -24.48871 20.35206  -0.16954  1.000 43.47605 ? 347 PRO A CB   1 
ATOM   2362 C CG   . PRO A 1 167 ? -25.74060 20.64546  -0.93730  1.000 44.97748 ? 347 PRO A CG   1 
ATOM   2363 C CD   . PRO A 1 167 ? -26.39388 19.31677  -1.15526  1.000 42.55289 ? 347 PRO A CD   1 
ATOM   2364 H HA   . PRO A 1 167 ? -24.08703 18.52288  0.71478   1.000 49.37024 ? 347 PRO A HA   1 
ATOM   2365 H HB2  . PRO A 1 167 ? -24.23946 21.10554  0.38817   1.000 49.91102 ? 347 PRO A HB2  1 
ATOM   2366 H HB3  . PRO A 1 167 ? -23.75955 20.12696  -0.76833  1.000 49.91102 ? 347 PRO A HB3  1 
ATOM   2367 H HG2  . PRO A 1 167 ? -26.31444 21.23143  -0.41938  1.000 54.42503 ? 347 PRO A HG2  1 
ATOM   2368 H HG3  . PRO A 1 167 ? -25.51714 21.06323  -1.78372  1.000 54.42503 ? 347 PRO A HG3  1 
ATOM   2369 H HD2  . PRO A 1 167 ? -27.35816 19.40892  -1.20606  1.000 48.80323 ? 347 PRO A HD2  1 
ATOM   2370 H HD3  . PRO A 1 167 ? -26.05815 18.89357  -1.96092  1.000 48.80323 ? 347 PRO A HD3  1 
ATOM   2371 N N    . GLU A 1 168 ? -24.27680 19.19633  3.05956   1.000 44.01848 ? 348 GLU A N    1 
ATOM   2372 C CA   . GLU A 1 168 ? -24.53058 19.42715  4.47422   1.000 44.79762 ? 348 GLU A CA   1 
ATOM   2373 C C    . GLU A 1 168 ? -24.63186 20.91864  4.76677   1.000 52.19933 ? 348 GLU A C    1 
ATOM   2374 O O    . GLU A 1 168 ? -23.79795 21.71185  4.32042   1.000 46.09404 ? 348 GLU A O    1 
ATOM   2375 C CB   . GLU A 1 168 ? -23.41810 18.79607  5.31213   1.000 48.80600 ? 348 GLU A CB   1 
ATOM   2376 C CG   . GLU A 1 168 ? -23.66777 18.83985  6.81030   1.000 48.88871 ? 348 GLU A CG   1 
ATOM   2377 H H    . GLU A 1 168 ? -23.52148 18.82099  2.89158   1.000 50.56193 ? 348 GLU A H    1 
ATOM   2378 H HA   . GLU A 1 168 ? -25.37305 19.01422  4.72047   1.000 51.49690 ? 348 GLU A HA   1 
ATOM   2379 H HB2  . GLU A 1 168 ? -23.32672 17.86501  5.05585   1.000 59.01925 ? 348 GLU A HB2  1 
ATOM   2380 H HB3  . GLU A 1 168 ? -22.59057 19.27101  5.13744   1.000 59.01925 ? 348 GLU A HB3  1 
ATOM   2381 H HG2  . GLU A 1 168 ? -23.45680 19.72760  7.13888   1.000 59.11850 ? 348 GLU A HG2  1 
ATOM   2382 H HG3  . GLU A 1 168 ? -24.60033 18.63569  6.98124   1.000 59.11850 ? 348 GLU A HG3  1 
ATOM   2383 N N    . GLY A 1 169 ? -25.66327 21.29709  5.51938   1.000 53.05441 ? 349 GLY A N    1 
ATOM   2384 C CA   . GLY A 1 169 ? -25.82060 22.65889  5.98131   1.000 51.98084 ? 349 GLY A CA   1 
ATOM   2385 C C    . GLY A 1 169 ? -26.41366 23.62581  4.98132   1.000 56.96056 ? 349 GLY A C    1 
ATOM   2386 O O    . GLY A 1 169 ? -26.54508 24.81393  5.30290   1.000 61.19227 ? 349 GLY A O    1 
ATOM   2387 H H    . GLY A 1 169 ? -26.29191 20.76942  5.77625   1.000 64.11734 ? 349 GLY A H    1 
ATOM   2388 H HA2  . GLY A 1 169 ? -26.39768 22.65415  6.76096   1.000 62.82906 ? 349 GLY A HA2  1 
ATOM   2389 H HA3  . GLY A 1 169 ? -24.94880 22.99968  6.23577   1.000 62.82906 ? 349 GLY A HA3  1 
ATOM   2390 N N    . LYS A 1 170 ? -26.77905 23.16856  3.78795   1.000 48.44271 ? 350 LYS A N    1 
ATOM   2391 C CA   . LYS A 1 170 ? -27.30878 24.04013  2.74955   1.000 46.59715 ? 350 LYS A CA   1 
ATOM   2392 C C    . LYS A 1 170 ? -28.83168 24.02619  2.76984   1.000 52.60649 ? 350 LYS A C    1 
ATOM   2393 O O    . LYS A 1 170 ? -29.45432 22.98638  3.00594   1.000 49.59663 ? 350 LYS A O    1 
ATOM   2394 C CB   . LYS A 1 170 ? -26.80000 23.61652  1.36872   1.000 45.87023 ? 350 LYS A CB   1 
ATOM   2395 C CG   . LYS A 1 170 ? -25.28649 23.75950  1.15178   1.000 46.04537 ? 350 LYS A CG   1 
ATOM   2396 C CD   . LYS A 1 170 ? -24.67865 24.96099  1.87400   1.000 47.27507 ? 350 LYS A CD   1 
ATOM   2397 C CE   . LYS A 1 170 ? -23.16304 24.97353  1.76366   1.000 48.77953 ? 350 LYS A CE   1 
ATOM   2398 N NZ   . LYS A 1 170 ? -22.59845 26.31121  2.09874   1.000 49.02012 ? 350 LYS A NZ   1 
ATOM   2399 H H    . LYS A 1 170 ? -26.72795 22.34265  3.55372   1.000 58.58330 ? 350 LYS A H    1 
ATOM   2400 H HA   . LYS A 1 170 ? -27.01503 24.94934  2.91675   1.000 55.67118 ? 350 LYS A HA   1 
ATOM   2401 H HB2  . LYS A 1 170 ? -27.02438 22.68251  1.23393   1.000 52.78403 ? 350 LYS A HB2  1 
ATOM   2402 H HB3  . LYS A 1 170 ? -27.24083 24.16350  0.69984   1.000 52.78403 ? 350 LYS A HB3  1 
ATOM   2403 H HG2  . LYS A 1 170 ? -24.84547 22.96106  1.48179   1.000 53.50506 ? 350 LYS A HG2  1 
ATOM   2404 H HG3  . LYS A 1 170 ? -25.11419 23.86561  0.20312   1.000 53.50506 ? 350 LYS A HG3  1 
ATOM   2405 H HD2  . LYS A 1 170 ? -25.01922 25.77874  1.47879   1.000 54.46984 ? 350 LYS A HD2  1 
ATOM   2406 H HD3  . LYS A 1 170 ? -24.91493 24.92336  2.81403   1.000 54.46984 ? 350 LYS A HD3  1 
ATOM   2407 H HE2  . LYS A 1 170 ? -22.79139 24.32320  2.37997   1.000 58.98749 ? 350 LYS A HE2  1 
ATOM   2408 H HE3  . LYS A 1 170 ? -22.90601 24.75369  0.85453   1.000 58.98749 ? 350 LYS A HE3  1 
ATOM   2409 H HZ1  . LYS A 1 170 ? -22.81849 26.53451  2.93170   1.000 56.56390 ? 350 LYS A HZ1  1 
ATOM   2410 H HZ2  . LYS A 1 170 ? -22.91951 26.92562  1.54060   1.000 56.56390 ? 350 LYS A HZ2  1 
ATOM   2411 H HZ3  . LYS A 1 170 ? -21.71135 26.29327  2.02928   1.000 56.56390 ? 350 LYS A HZ3  1 
ATOM   2412 N N    . ALA A 1 171 ? -29.42460 25.19521  2.51899   1.000 47.33535 ? 351 ALA A N    1 
ATOM   2413 C CA   . ALA A 1 171 ? -30.87436 25.33306  2.50007   1.000 47.55569 ? 351 ALA A CA   1 
ATOM   2414 C C    . ALA A 1 171 ? -31.51280 24.68038  1.28274   1.000 46.85633 ? 351 ALA A C    1 
ATOM   2415 O O    . ALA A 1 171 ? -32.74413 24.62654  1.20973   1.000 47.06002 ? 351 ALA A O    1 
ATOM   2416 C CB   . ALA A 1 171 ? -31.25910 26.81304  2.54749   1.000 48.65649 ? 351 ALA A CB   1 
ATOM   2417 H H    . ALA A 1 171 ? -29.00343 25.92706  2.35583   1.000 56.13658 ? 351 ALA A H    1 
ATOM   2418 H HA   . ALA A 1 171 ? -31.23468 24.90271  3.29119   1.000 54.80659 ? 351 ALA A HA   1 
ATOM   2419 H HB1  . ALA A 1 171 ? -32.22608 26.88850  2.53556   1.000 56.12755 ? 351 ALA A HB1  1 
ATOM   2420 H HB2  . ALA A 1 171 ? -30.90674 27.20500  3.36180   1.000 56.12755 ? 351 ALA A HB2  1 
ATOM   2421 H HB3  . ALA A 1 171 ? -30.88272 27.26211  1.77445   1.000 56.12755 ? 351 ALA A HB3  1 
ATOM   2422 N N    . GLN A 1 172 ? -30.71693 24.20715  0.32607   1.000 46.17602 ? 352 GLN A N    1 
ATOM   2423 C CA   . GLN A 1 172 ? -31.23114 23.54056  -0.86028  1.000 45.58271 ? 352 GLN A CA   1 
ATOM   2424 C C    . GLN A 1 172 ? -30.30269 22.39153  -1.22438  1.000 44.64566 ? 352 GLN A C    1 
ATOM   2425 O O    . GLN A 1 172 ? -29.13151 22.36809  -0.83827  1.000 44.55284 ? 352 GLN A O    1 
ATOM   2426 C CB   . GLN A 1 172 ? -31.35221 24.50769  -2.04564  1.000 49.90536 ? 352 GLN A CB   1 
ATOM   2427 C CG   . GLN A 1 172 ? -32.56104 25.42475  -1.98658  1.000 46.94853 ? 352 GLN A CG   1 
ATOM   2428 C CD   . GLN A 1 172 ? -32.24501 26.83067  -2.45979  1.000 61.64144 ? 352 GLN A CD   1 
ATOM   2429 O OE1  . GLN A 1 172 ? -31.70758 27.64491  -1.70862  1.000 48.52606 ? 352 GLN A OE1  1 
ATOM   2430 N NE2  . GLN A 1 172 ? -32.57450 27.12168  -3.71324  1.000 67.20634 ? 352 GLN A NE2  1 
ATOM   2431 H H    . GLN A 1 172 ? -29.85892 24.26265  0.34448   1.000 53.15098 ? 352 GLN A H    1 
ATOM   2432 H HA   . GLN A 1 172 ? -32.11080 23.17901  -0.66956  1.000 52.44207 ? 352 GLN A HA   1 
ATOM   2433 H HB2  . GLN A 1 172 ? -30.56035 25.06738  -2.07022  1.000 60.33848 ? 352 GLN A HB2  1 
ATOM   2434 H HB3  . GLN A 1 172 ? -31.41726 23.98888  -2.86265  1.000 60.33848 ? 352 GLN A HB3  1 
ATOM   2435 H HG2  . GLN A 1 172 ? -33.25996 25.06547  -2.55520  1.000 54.07799 ? 352 GLN A HG2  1 
ATOM   2436 H HG3  . GLN A 1 172 ? -32.87398 25.47860  -1.07002  1.000 54.07799 ? 352 GLN A HG3  1 
ATOM   2437 H HE21 . GLN A 1 172 ? -32.94654 26.52589  -4.20944  1.000 81.09965 ? 352 GLN A HE21 1 
ATOM   2438 H HE22 . GLN A 1 172 ? -32.41578 27.90588  -4.02857  1.000 81.09965 ? 352 GLN A HE22 1 
ATOM   2439 N N    . PHE A 1 173 ? -30.83938 21.43303  -1.97229  1.000 44.06136 ? 353 PHE A N    1 
ATOM   2440 C CA   . PHE A 1 173 ? -30.04920 20.33752  -2.51283  1.000 43.22212 ? 353 PHE A CA   1 
ATOM   2441 C C    . PHE A 1 173 ? -29.72391 20.60584  -3.97842  1.000 43.14030 ? 353 PHE A C    1 
ATOM   2442 O O    . PHE A 1 173 ? -30.35777 21.43201  -4.63997  1.000 49.74471 ? 353 PHE A O    1 
ATOM   2443 C CB   . PHE A 1 173 ? -30.77833 18.99565  -2.35698  1.000 42.75840 ? 353 PHE A CB   1 
ATOM   2444 C CG   . PHE A 1 173 ? -32.17696 18.98019  -2.91300  1.000 43.07434 ? 353 PHE A CG   1 
ATOM   2445 C CD1  . PHE A 1 173 ? -32.40606 19.11339  -4.27315  1.000 43.05075 ? 353 PHE A CD1  1 
ATOM   2446 C CD2  . PHE A 1 173 ? -33.26322 18.81464  -2.07065  1.000 43.54866 ? 353 PHE A CD2  1 
ATOM   2447 C CE1  . PHE A 1 173 ? -33.69043 19.09373  -4.77904  1.000 48.72819 ? 353 PHE A CE1  1 
ATOM   2448 C CE2  . PHE A 1 173 ? -34.55023 18.79249  -2.57121  1.000 44.00014 ? 353 PHE A CE2  1 
ATOM   2449 C CZ   . PHE A 1 173 ? -34.76414 18.93240  -3.92686  1.000 46.90360 ? 353 PHE A CZ   1 
ATOM   2450 H H    . PHE A 1 173 ? -31.67251 21.39688  -2.18250  1.000 50.61339 ? 353 PHE A H    1 
ATOM   2451 H HA   . PHE A 1 173 ? -29.21515 20.26724  -2.02262  1.000 50.67088 ? 353 PHE A HA   1 
ATOM   2452 H HB2  . PHE A 1 173 ? -30.27053 18.31181  -2.82109  1.000 49.04984 ? 353 PHE A HB2  1 
ATOM   2453 H HB3  . PHE A 1 173 ? -30.83575 18.78254  -1.41242  1.000 49.04984 ? 353 PHE A HB3  1 
ATOM   2454 H HD1  . PHE A 1 173 ? -31.68583 19.21730  -4.85226  1.000 50.54410 ? 353 PHE A HD1  1 
ATOM   2455 H HD2  . PHE A 1 173 ? -33.12448 18.71713  -1.15624  1.000 49.99815 ? 353 PHE A HD2  1 
ATOM   2456 H HE1  . PHE A 1 173 ? -33.83206 19.18910  -5.69323  1.000 58.92587 ? 353 PHE A HE1  1 
ATOM   2457 H HE2  . PHE A 1 173 ? -35.27197 18.68336  -1.99494  1.000 50.53992 ? 353 PHE A HE2  1 
ATOM   2458 H HZ   . PHE A 1 173 ? -35.63002 18.91804  -4.26587  1.000 56.73637 ? 353 PHE A HZ   1 
ATOM   2459 N N    . ALA A 1 174 ? -28.71784 19.89527  -4.47951  1.000 32.61198 ? 354 ALA A N    1 
ATOM   2460 C CA   . ALA A 1 174 ? -28.21125 20.09062  -5.83189  1.000 33.19210 ? 354 ALA A CA   1 
ATOM   2461 C C    . ALA A 1 174 ? -28.65817 18.93122  -6.71079  1.000 36.71414 ? 354 ALA A C    1 
ATOM   2462 O O    . ALA A 1 174 ? -28.32192 17.77503  -6.43828  1.000 37.50387 ? 354 ALA A O    1 
ATOM   2463 C CB   . ALA A 1 174 ? -26.68663 20.20313  -5.83000  1.000 32.08404 ? 354 ALA A CB   1 
ATOM   2464 H H    . ALA A 1 174 ? -28.30392 19.28015  -4.04375  1.000 36.87413 ? 354 ALA A H    1 
ATOM   2465 H HA   . ALA A 1 174 ? -28.58422 20.90816  -6.19716  1.000 40.28257 ? 354 ALA A HA   1 
ATOM   2466 H HB1  . ALA A 1 174 ? -26.37831 20.33145  -6.74070  1.000 38.95290 ? 354 ALA A HB1  1 
ATOM   2467 H HB2  . ALA A 1 174 ? -26.42655 20.96070  -5.28288  1.000 38.95290 ? 354 ALA A HB2  1 
ATOM   2468 H HB3  . ALA A 1 174 ? -26.31019 19.38694  -5.46525  1.000 38.95290 ? 354 ALA A HB3  1 
ATOM   2469 N N    . ASP A 1 175 ? -29.40288 19.24176  -7.76610  1.000 33.27979 ? 355 ASP A N    1 
ATOM   2470 C CA   . ASP A 1 175 ? -29.82559 18.25108  -8.74659  1.000 33.09488 ? 355 ASP A CA   1 
ATOM   2471 C C    . ASP A 1 175 ? -28.89282 18.33420  -9.94772  1.000 36.64530 ? 355 ASP A C    1 
ATOM   2472 O O    . ASP A 1 175 ? -28.78211 19.39153  -10.57849 1.000 35.31679 ? 355 ASP A O    1 
ATOM   2473 C CB   . ASP A 1 175 ? -31.27520 18.48336  -9.17141  1.000 43.45896 ? 355 ASP A CB   1 
ATOM   2474 C CG   . ASP A 1 175 ? -32.26881 18.10270  -8.09031  1.000 36.75740 ? 355 ASP A CG   1 
ATOM   2475 O OD1  . ASP A 1 175 ? -31.92671 17.26058  -7.23404  1.000 39.62477 ? 355 ASP A OD1  1 
ATOM   2476 O OD2  . ASP A 1 175 ? -33.39390 18.64521  -8.09818  1.000 43.81523 ? 355 ASP A OD2  1 
ATOM   2477 H H    . ASP A 1 175 ? -29.68123 20.03699  -7.93853  1.000 40.38780 ? 355 ASP A H    1 
ATOM   2478 H HA   . ASP A 1 175 ? -29.76506 17.36239  -8.36257  1.000 40.16590 ? 355 ASP A HA   1 
ATOM   2479 H HB2  . ASP A 1 175 ? -31.39853 19.42367  -9.37517  1.000 52.60280 ? 355 ASP A HB2  1 
ATOM   2480 H HB3  . ASP A 1 175 ? -31.46494 17.94614  -9.95645  1.000 52.60280 ? 355 ASP A HB3  1 
ATOM   2481 N N    . ILE A 1 176 ? -28.22368 17.22762  -10.25843 1.000 35.09315 ? 356 ILE A N    1 
ATOM   2482 C CA   . ILE A 1 176 ? -27.28939 17.14911  -11.37242 1.000 35.81597 ? 356 ILE A CA   1 
ATOM   2483 C C    . ILE A 1 176 ? -27.88660 16.19844  -12.39744 1.000 41.16227 ? 356 ILE A C    1 
ATOM   2484 O O    . ILE A 1 176 ? -27.96037 14.98443  -12.16562 1.000 36.56640 ? 356 ILE A O    1 
ATOM   2485 C CB   . ILE A 1 176 ? -25.90083 16.67275  -10.92493 1.000 29.20663 ? 356 ILE A CB   1 
ATOM   2486 C CG1  . ILE A 1 176 ? -25.44296 17.43264  -9.67630  1.000 35.54574 ? 356 ILE A CG1  1 
ATOM   2487 C CG2  . ILE A 1 176 ? -24.89863 16.83356  -12.05822 1.000 33.83512 ? 356 ILE A CG2  1 
ATOM   2488 C CD1  . ILE A 1 176 ? -25.37802 18.93635  -9.85315  1.000 39.13033 ? 356 ILE A CD1  1 
ATOM   2489 H H    . ILE A 1 176 ? -28.29801 16.48895  -9.82433  1.000 42.56383 ? 356 ILE A H    1 
ATOM   2490 H HA   . ILE A 1 176 ? -27.19767 18.02664  -11.77544 1.000 43.43122 ? 356 ILE A HA   1 
ATOM   2491 H HB   . ILE A 1 176 ? -25.95851 15.73184  -10.69631 1.000 35.50000 ? 356 ILE A HB   1 
ATOM   2492 H HG12 . ILE A 1 176 ? -26.06496 17.24784  -8.95527  1.000 43.10693 ? 356 ILE A HG12 1 
ATOM   2493 H HG13 . ILE A 1 176 ? -24.55483 17.12620  -9.43500  1.000 43.10693 ? 356 ILE A HG13 1 
ATOM   2494 H HG21 . ILE A 1 176 ? -24.00909 16.64072  -11.72289 1.000 41.05419 ? 356 ILE A HG21 1 
ATOM   2495 H HG22 . ILE A 1 176 ? -25.12505 16.21491  -12.77019 1.000 41.05419 ? 356 ILE A HG22 1 
ATOM   2496 H HG23 . ILE A 1 176 ? -24.93764 17.74520  -12.38730 1.000 41.05419 ? 356 ILE A HG23 1 
ATOM   2497 H HD11 . ILE A 1 176 ? -25.04388 19.33640  -9.03509  1.000 47.40845 ? 356 ILE A HD11 1 
ATOM   2498 H HD12 . ILE A 1 176 ? -24.78139 19.14222  -10.58973 1.000 47.40845 ? 356 ILE A HD12 1 
ATOM   2499 H HD13 . ILE A 1 176 ? -26.26817 19.27049  -10.04518 1.000 47.40845 ? 356 ILE A HD13 1 
ATOM   2500 N N    . GLU A 1 177 ? -28.31968 16.74489  -13.52171 1.000 37.57666 ? 357 GLU A N    1 
ATOM   2501 C CA   . GLU A 1 177 ? -28.78677 15.89867  -14.60712 1.000 37.97598 ? 357 GLU A CA   1 
ATOM   2502 C C    . GLU A 1 177 ? -27.58886 15.28154  -15.32711 1.000 39.96995 ? 357 GLU A C    1 
ATOM   2503 O O    . GLU A 1 177 ? -26.58678 15.96437  -15.55722 1.000 28.93101 ? 357 GLU A O    1 
ATOM   2504 C CB   . GLU A 1 177 ? -29.62930 16.70552  -15.58952 1.000 37.26603 ? 357 GLU A CB   1 
ATOM   2505 C CG   . GLU A 1 177 ? -31.05242 16.94265  -15.11493 1.000 38.25836 ? 357 GLU A CG   1 
ATOM   2506 C CD   . GLU A 1 177 ? -31.75809 18.03437  -15.89471 1.000 36.01975 ? 357 GLU A CD   1 
ATOM   2507 O OE1  . GLU A 1 177 ? -31.59431 18.08507  -17.13156 1.000 38.99622 ? 357 GLU A OE1  1 
ATOM   2508 O OE2  . GLU A 1 177 ? -32.47833 18.84051  -15.27003 1.000 46.97219 ? 357 GLU A OE2  1 
ATOM   2509 H H    . GLU A 1 177 ? -28.35330 17.58952  -13.68005 1.000 45.54404 ? 357 GLU A H    1 
ATOM   2510 H HA   . GLU A 1 177 ? -29.34052 15.18326  -14.25718 1.000 46.02322 ? 357 GLU A HA   1 
ATOM   2511 H HB2  . GLU A 1 177 ? -29.21206 17.57113  -15.72193 1.000 45.17128 ? 357 GLU A HB2  1 
ATOM   2512 H HB3  . GLU A 1 177 ? -29.67285 16.22595  -16.43155 1.000 45.17128 ? 357 GLU A HB3  1 
ATOM   2513 H HG2  . GLU A 1 177 ? -31.56089 16.12324  -15.21946 1.000 46.36208 ? 357 GLU A HG2  1 
ATOM   2514 H HG3  . GLU A 1 177 ? -31.03441 17.20510  -14.18128 1.000 46.36208 ? 357 GLU A HG3  1 
ATOM   2515 N N    . PRO A 1 178 ? -27.65521 13.99577  -15.69283 1.000 34.75305 ? 358 PRO A N    1 
ATOM   2516 C CA   . PRO A 1 178 ? -26.51162 13.37617  -16.37898 1.000 33.10343 ? 358 PRO A CA   1 
ATOM   2517 C C    . PRO A 1 178 ? -26.34339 13.90883  -17.79371 1.000 40.29363 ? 358 PRO A C    1 
ATOM   2518 O O    . PRO A 1 178 ? -26.37153 13.14945  -18.76769 1.000 30.47566 ? 358 PRO A O    1 
ATOM   2519 C CB   . PRO A 1 178 ? -26.86252 11.88251  -16.36406 1.000 32.06767 ? 358 PRO A CB   1 
ATOM   2520 C CG   . PRO A 1 178 ? -28.34895 11.85072  -16.29628 1.000 32.17335 ? 358 PRO A CG   1 
ATOM   2521 C CD   . PRO A 1 178 ? -28.73938 13.02676  -15.44764 1.000 32.14190 ? 358 PRO A CD   1 
ATOM   2522 H HA   . PRO A 1 178 ? -25.69005 13.51225  -15.88159 1.000 40.17616 ? 358 PRO A HA   1 
ATOM   2523 H HB2  . PRO A 1 178 ? -26.54083 11.45743  -17.17445 1.000 38.93325 ? 358 PRO A HB2  1 
ATOM   2524 H HB3  . PRO A 1 178 ? -26.46842 11.45628  -15.58694 1.000 38.93325 ? 358 PRO A HB3  1 
ATOM   2525 H HG2  . PRO A 1 178 ? -28.72005 11.93161  -17.18883 1.000 36.34777 ? 358 PRO A HG2  1 
ATOM   2526 H HG3  . PRO A 1 178 ? -28.64130 11.02011  -15.88945 1.000 36.34777 ? 358 PRO A HG3  1 
ATOM   2527 H HD2  . PRO A 1 178 ? -29.59481 13.38704  -15.72930 1.000 37.19235 ? 358 PRO A HD2  1 
ATOM   2528 H HD3  . PRO A 1 178 ? -28.77599 12.77933  -14.51044 1.000 37.19235 ? 358 PRO A HD3  1 
ATOM   2529 N N    . LYS A 1 179 ? -26.15381 15.22079  -17.90792 1.000 37.14276 ? 359 LYS A N    1 
ATOM   2530 C CA   . LYS A 1 179 ? -26.13644 15.87616  -19.20657 1.000 32.90095 ? 359 LYS A CA   1 
ATOM   2531 C C    . LYS A 1 179 ? -24.87992 15.50654  -19.98716 1.000 28.67846 ? 359 LYS A C    1 
ATOM   2532 O O    . LYS A 1 179 ? -23.81335 15.25665  -19.41966 1.000 27.90877 ? 359 LYS A O    1 
ATOM   2533 C CB   . LYS A 1 179 ? -26.22693 17.39369  -19.03011 1.000 36.86167 ? 359 LYS A CB   1 
ATOM   2534 C CG   . LYS A 1 179 ? -25.94832 18.20258  -20.28871 1.000 35.61599 ? 359 LYS A CG   1 
ATOM   2535 C CD   . LYS A 1 179 ? -26.10026 19.69432  -20.02850 1.000 35.47778 ? 359 LYS A CD   1 
ATOM   2536 C CE   . LYS A 1 179 ? -25.86993 20.50590  -21.29263 1.000 30.62412 ? 359 LYS A CE   1 
ATOM   2537 H H    . LYS A 1 179 ? -26.03248 15.75447  -17.24454 1.000 45.02337 ? 359 LYS A H    1 
ATOM   2538 H HA   . LYS A 1 179 ? -26.90145 15.58573  -19.72744 1.000 39.93319 ? 359 LYS A HA   1 
ATOM   2539 H HB2  . LYS A 1 179 ? -27.12340 17.61576  -18.73360 1.000 44.68606 ? 359 LYS A HB2  1 
ATOM   2540 H HB3  . LYS A 1 179 ? -25.57942 17.66444  -18.36054 1.000 44.68606 ? 359 LYS A HB3  1 
ATOM   2541 H HG2  . LYS A 1 179 ? -25.04034 18.03449  -20.58572 1.000 43.19124 ? 359 LYS A HG2  1 
ATOM   2542 H HG3  . LYS A 1 179 ? -26.57681 17.94712  -20.98199 1.000 43.19124 ? 359 LYS A HG3  1 
ATOM   2543 H HD2  . LYS A 1 179 ? -26.99826 19.87510  -19.70943 1.000 43.02539 ? 359 LYS A HD2  1 
ATOM   2544 H HD3  . LYS A 1 179 ? -25.45002 19.97265  -19.36470 1.000 43.02539 ? 359 LYS A HD3  1 
ATOM   2545 N N    . PHE A 1 180 ? -25.02353 15.47461  -21.30935 1.000 31.96483 ? 360 PHE A N    1 
ATOM   2546 C CA   . PHE A 1 180 ? -23.91549 15.12472  -22.18716 1.000 28.96613 ? 360 PHE A CA   1 
ATOM   2547 C C    . PHE A 1 180 ? -22.75578 16.09783  -22.01022 1.000 30.32334 ? 360 PHE A C    1 
ATOM   2548 O O    . PHE A 1 180 ? -22.94682 17.31709  -21.99608 1.000 27.67192 ? 360 PHE A O    1 
ATOM   2549 C CB   . PHE A 1 180 ? -24.39947 15.12575  -23.63882 1.000 32.47576 ? 360 PHE A CB   1 
ATOM   2550 C CG   . PHE A 1 180 ? -23.31981 14.85146  -24.64495 1.000 35.99724 ? 360 PHE A CG   1 
ATOM   2551 C CD1  . PHE A 1 180 ? -22.90557 13.55526  -24.90254 1.000 40.36868 ? 360 PHE A CD1  1 
ATOM   2552 C CD2  . PHE A 1 180 ? -22.72835 15.88971  -25.34343 1.000 30.99162 ? 360 PHE A CD2  1 
ATOM   2553 C CE1  . PHE A 1 180 ? -21.91545 13.30156  -25.83232 1.000 38.72432 ? 360 PHE A CE1  1 
ATOM   2554 C CE2  . PHE A 1 180 ? -21.73847 15.64236  -26.27342 1.000 40.78674 ? 360 PHE A CE2  1 
ATOM   2555 C CZ   . PHE A 1 180 ? -21.33165 14.34664  -26.51851 1.000 40.36312 ? 360 PHE A CZ   1 
ATOM   2556 H H    . PHE A 1 180 ? -25.75583 15.65233  -21.72379 1.000 38.80984 ? 360 PHE A H    1 
ATOM   2557 H HA   . PHE A 1 180 ? -23.59167 14.23743  -21.96635 1.000 33.54255 ? 360 PHE A HA   1 
ATOM   2558 H HB2  . PHE A 1 180 ? -25.07799 14.44005  -23.74047 1.000 39.42297 ? 360 PHE A HB2  1 
ATOM   2559 H HB3  . PHE A 1 180 ? -24.77544 15.99695  -23.84024 1.000 39.42297 ? 360 PHE A HB3  1 
ATOM   2560 H HD1  . PHE A 1 180 ? -23.29830 12.84755  -24.44449 1.000 48.89446 ? 360 PHE A HD1  1 
ATOM   2561 H HD2  . PHE A 1 180 ? -23.00103 16.76449  -25.18436 1.000 37.64199 ? 360 PHE A HD2  1 
ATOM   2562 H HE1  . PHE A 1 180 ? -21.64285 12.42749  -25.99542 1.000 46.92123 ? 360 PHE A HE1  1 
ATOM   2563 H HE2  . PHE A 1 180 ? -21.34611 16.34839  -26.73438 1.000 49.39614 ? 360 PHE A HE2  1 
ATOM   2564 H HZ   . PHE A 1 180 ? -20.66528 14.17817  -27.14498 1.000 48.88780 ? 360 PHE A HZ   1 
ATOM   2565 N N    . ASP A 1 181 ? -21.54769 15.54898  -21.87490 1.000 28.80497 ? 361 ASP A N    1 
ATOM   2566 C CA   . ASP A 1 181 ? -20.30502 16.31310  -21.80485 1.000 31.97056 ? 361 ASP A CA   1 
ATOM   2567 C C    . ASP A 1 181 ? -20.15440 17.09350  -20.50386 1.000 26.50975 ? 361 ASP A C    1 
ATOM   2568 O O    . ASP A 1 181 ? -19.36628 18.04265  -20.44070 1.000 24.39610 ? 361 ASP A O    1 
ATOM   2569 C CB   . ASP A 1 181 ? -20.18314 17.27298  -22.99563 1.000 30.78963 ? 361 ASP A CB   1 
ATOM   2570 C CG   . ASP A 1 181 ? -18.74074 17.62027  -23.32477 1.000 25.88638 ? 361 ASP A CG   1 
ATOM   2571 O OD1  . ASP A 1 181 ? -17.82596 16.92029  -22.84186 1.000 28.76798 ? 361 ASP A OD1  1 
ATOM   2572 O OD2  . ASP A 1 181 ? -18.52119 18.59356  -24.07490 1.000 25.27192 ? 361 ASP A OD2  1 
ATOM   2573 H H    . ASP A 1 181 ? -21.41983 14.70035  -21.81944 1.000 35.01801 ? 361 ASP A H    1 
ATOM   2574 H HA   . ASP A 1 181 ? -19.57021 15.68090  -21.84060 1.000 38.81672 ? 361 ASP A HA   1 
ATOM   2575 H HB2  . ASP A 1 181 ? -20.57783 16.85757  -23.77829 1.000 37.39960 ? 361 ASP A HB2  1 
ATOM   2576 H HB3  . ASP A 1 181 ? -20.64996 18.09713  -22.78647 1.000 37.39960 ? 361 ASP A HB3  1 
ATOM   2577 N N    . ARG A 1 182 ? -20.87755 16.71184  -19.45511 1.000 32.81951 ? 362 ARG A N    1 
ATOM   2578 C CA   . ARG A 1 182 ? -20.81536 17.41415  -18.18143 1.000 29.05289 ? 362 ARG A CA   1 
ATOM   2579 C C    . ARG A 1 182 ? -19.80671 16.75077  -17.25313 1.000 28.16302 ? 362 ARG A C    1 
ATOM   2580 O O    . ARG A 1 182 ? -19.76964 15.52325  -17.12828 1.000 24.08027 ? 362 ARG A O    1 
ATOM   2581 C CB   . ARG A 1 182 ? -22.19201 17.44455  -17.51450 1.000 29.86936 ? 362 ARG A CB   1 
ATOM   2582 C CG   . ARG A 1 182 ? -22.17734 17.95638  -16.08037 1.000 27.00022 ? 362 ARG A CG   1 
ATOM   2583 C CD   . ARG A 1 182 ? -23.58531 18.12928  -15.53451 1.000 26.75930 ? 362 ARG A CD   1 
ATOM   2584 N NE   . ARG A 1 182 ? -24.23491 19.32539  -16.05779 1.000 27.10582 ? 362 ARG A NE   1 
ATOM   2585 C CZ   . ARG A 1 182 ? -25.47490 19.69417  -15.76547 1.000 28.94382 ? 362 ARG A CZ   1 
ATOM   2586 N NH1  . ARG A 1 182 ? -26.23800 18.97631  -14.95729 1.000 28.36190 ? 362 ARG A NH1  1 
ATOM   2587 N NH2  . ARG A 1 182 ? -25.96167 20.81181  -16.29726 1.000 28.62316 ? 362 ARG A NH2  1 
ATOM   2588 H H    . ARG A 1 182 ? -21.41679 16.04190  -19.45804 1.000 39.83546 ? 362 ARG A H    1 
ATOM   2589 H HA   . ARG A 1 182 ? -20.52945 18.32799  -18.33653 1.000 35.31551 ? 362 ARG A HA   1 
ATOM   2590 H HB2  . ARG A 1 182 ? -22.77339 18.02613  -18.02895 1.000 36.29528 ? 362 ARG A HB2  1 
ATOM   2591 H HB3  . ARG A 1 182 ? -22.55088 16.54346  -17.50208 1.000 36.29528 ? 362 ARG A HB3  1 
ATOM   2592 H HG2  . ARG A 1 182 ? -21.70834 17.32076  -15.51740 1.000 32.85231 ? 362 ARG A HG2  1 
ATOM   2593 H HG3  . ARG A 1 182 ? -21.73153 18.81737  -16.05129 1.000 32.85231 ? 362 ARG A HG3  1 
ATOM   2594 H HD2  . ARG A 1 182 ? -24.12082 17.36028  -15.78506 1.000 32.56321 ? 362 ARG A HD2  1 
ATOM   2595 H HD3  . ARG A 1 182 ? -23.54535 18.20512  -14.56831 1.000 32.56321 ? 362 ARG A HD3  1 
ATOM   2596 H HE   . ARG A 1 182 ? -23.78336 19.82557  -16.59214 1.000 32.97903 ? 362 ARG A HE   1 
ATOM   2597 H HH11 . ARG A 1 182 ? -25.93258 18.25215  -14.60813 1.000 33.53863 ? 362 ARG A HH11 1 
ATOM   2598 H HH12 . ARG A 1 182 ? -27.03939 19.23390  -14.78117 1.000 33.53863 ? 362 ARG A HH12 1 
ATOM   2599 H HH21 . ARG A 1 182 ? -25.47371 21.28559  -16.82360 1.000 32.08755 ? 362 ARG A HH21 1 
ATOM   2600 H HH22 . ARG A 1 182 ? -26.76438 21.06073  -16.11480 1.000 32.08755 ? 362 ARG A HH22 1 
ATOM   2601 N N    . LEU A 1 183 ? -18.98930 17.57520  -16.60351 1.000 21.27743 ? 363 LEU A N    1 
ATOM   2602 C CA   . LEU A 1 183 ? -18.03594 17.12650  -15.59937 1.000 26.03625 ? 363 LEU A CA   1 
ATOM   2603 C C    . LEU A 1 183 ? -18.47463 17.63495  -14.23260 1.000 28.78938 ? 363 LEU A C    1 
ATOM   2604 O O    . LEU A 1 183 ? -18.94580 18.76776  -14.10409 1.000 22.59481 ? 363 LEU A O    1 
ATOM   2605 C CB   . LEU A 1 183 ? -16.62334 17.62331  -15.91819 1.000 29.87818 ? 363 LEU A CB   1 
ATOM   2606 C CG   . LEU A 1 183 ? -15.50497 17.09569  -15.01635 1.000 18.13320 ? 363 LEU A CG   1 
ATOM   2607 C CD1  . LEU A 1 183 ? -15.15523 15.66197  -15.38365 1.000 26.83857 ? 363 LEU A CD1  1 
ATOM   2608 C CD2  . LEU A 1 183 ? -14.27693 17.98495  -15.10599 1.000 23.51163 ? 363 LEU A CD2  1 
ATOM   2609 H H    . LEU A 1 183 ? -18.96980 18.42516  -16.73312 1.000 24.03633 ? 363 LEU A H    1 
ATOM   2610 H HA   . LEU A 1 183 ? -18.01009 16.15711  -15.57654 1.000 31.69554 ? 363 LEU A HA   1 
ATOM   2611 H HB2  . LEU A 1 183 ? -16.40808 17.35929  -16.82641 1.000 36.30586 ? 363 LEU A HB2  1 
ATOM   2612 H HB3  . LEU A 1 183 ? -16.61938 18.59047  -15.84407 1.000 36.30586 ? 363 LEU A HB3  1 
ATOM   2613 H HG   . LEU A 1 183 ? -15.81332 17.10494  -14.09671 1.000 22.21189 ? 363 LEU A HG   1 
ATOM   2614 H HD11 . LEU A 1 183 ? -14.34091 15.40740  -14.92214 1.000 32.65833 ? 363 LEU A HD11 1 
ATOM   2615 H HD12 . LEU A 1 183 ? -15.88349 15.08043  -15.11467 1.000 32.65833 ? 363 LEU A HD12 1 
ATOM   2616 H HD13 . LEU A 1 183 ? -15.02341 15.60491  -16.34296 1.000 32.65833 ? 363 LEU A HD13 1 
ATOM   2617 H HD21 . LEU A 1 183 ? -13.56111 17.58830  -14.58525 1.000 28.66600 ? 363 LEU A HD21 1 
ATOM   2618 H HD22 . LEU A 1 183 ? -14.00808 18.05941  -16.03501 1.000 28.66600 ? 363 LEU A HD22 1 
ATOM   2619 H HD23 . LEU A 1 183 ? -14.49560 18.86183  -14.75362 1.000 28.66600 ? 363 LEU A HD23 1 
ATOM   2620 N N    . LEU A 1 184 ? -18.32135 16.79374  -13.21409 1.000 23.54296 ? 364 LEU A N    1 
ATOM   2621 C CA   . LEU A 1 184 ? -18.80152 17.09160  -11.87259 1.000 20.10688 ? 364 LEU A CA   1 
ATOM   2622 C C    . LEU A 1 184 ? -17.72090 16.74926  -10.86136 1.000 25.54188 ? 364 LEU A C    1 
ATOM   2623 O O    . LEU A 1 184 ? -17.10702 15.68250  -10.94550 1.000 18.55994 ? 364 LEU A O    1 
ATOM   2624 C CB   . LEU A 1 184 ? -20.08180 16.30393  -11.56396 1.000 21.13962 ? 364 LEU A CB   1 
ATOM   2625 C CG   . LEU A 1 184 ? -20.57019 16.30813  -10.11293 1.000 24.05000 ? 364 LEU A CG   1 
ATOM   2626 C CD1  . LEU A 1 184 ? -21.15587 17.66142  -9.74588  1.000 22.15312 ? 364 LEU A CD1  1 
ATOM   2627 C CD2  . LEU A 1 184 ? -21.58939 15.19905  -9.89262  1.000 23.35404 ? 364 LEU A CD2  1 
ATOM   2628 H H    . LEU A 1 184 ? -17.93395 16.02868  -13.27887 1.000 28.70360 ? 364 LEU A H    1 
ATOM   2629 H HA   . LEU A 1 184 ? -18.99292 18.03974  -11.79976 1.000 24.58030 ? 364 LEU A HA   1 
ATOM   2630 H HB2  . LEU A 1 184 ? -20.79731 16.67458  -12.10393 1.000 23.10730 ? 364 LEU A HB2  1 
ATOM   2631 H HB3  . LEU A 1 184 ? -19.92800 15.37771  -11.80758 1.000 23.10730 ? 364 LEU A HB3  1 
ATOM   2632 H HG   . LEU A 1 184 ? -19.81615 16.14426  -9.52516  1.000 29.31205 ? 364 LEU A HG   1 
ATOM   2633 H HD11 . LEU A 1 184 ? -21.48849 17.62513  -8.83542  1.000 27.03579 ? 364 LEU A HD11 1 
ATOM   2634 H HD12 . LEU A 1 184 ? -20.46235 18.33575  -9.81805  1.000 27.03579 ? 364 LEU A HD12 1 
ATOM   2635 H HD13 . LEU A 1 184 ? -21.88193 17.86711  -10.35534 1.000 27.03579 ? 364 LEU A HD13 1 
ATOM   2636 H HD21 . LEU A 1 184 ? -21.87756 15.21437  -8.96654  1.000 28.47690 ? 364 LEU A HD21 1 
ATOM   2637 H HD22 . LEU A 1 184 ? -22.34869 15.34711  -10.47780 1.000 28.47690 ? 364 LEU A HD22 1 
ATOM   2638 H HD23 . LEU A 1 184 ? -21.17622 14.34543  -10.09640 1.000 28.47690 ? 364 LEU A HD23 1 
ATOM   2639 N N    . PHE A 1 185 ? -17.50136 17.65318  -9.91029  1.000 25.99189 ? 365 PHE A N    1 
ATOM   2640 C CA   . PHE A 1 185 ? -16.64047 17.42532  -8.75954  1.000 19.17408 ? 365 PHE A CA   1 
ATOM   2641 C C    . PHE A 1 185 ? -17.46651 17.58795  -7.49207  1.000 20.79355 ? 365 PHE A C    1 
ATOM   2642 O O    . PHE A 1 185 ? -18.33352 18.46394  -7.42260  1.000 20.07307 ? 365 PHE A O    1 
ATOM   2643 C CB   . PHE A 1 185 ? -15.47411 18.41930  -8.71166  1.000 17.18431 ? 365 PHE A CB   1 
ATOM   2644 C CG   . PHE A 1 185 ? -14.54294 18.33755  -9.88207  1.000 20.38714 ? 365 PHE A CG   1 
ATOM   2645 C CD1  . PHE A 1 185 ? -13.47472 17.45834  -9.87369  1.000 22.26655 ? 365 PHE A CD1  1 
ATOM   2646 C CD2  . PHE A 1 185 ? -14.71777 19.16330  -10.97895 1.000 23.05989 ? 365 PHE A CD2  1 
ATOM   2647 C CE1  . PHE A 1 185 ? -12.60863 17.39097  -10.94546 1.000 15.30015 ? 365 PHE A CE1  1 
ATOM   2648 C CE2  . PHE A 1 185 ? -13.85587 19.10091  -12.05286 1.000 16.22622 ? 365 PHE A CE2  1 
ATOM   2649 C CZ   . PHE A 1 185 ? -12.79901 18.21592  -12.03662 1.000 20.29817 ? 365 PHE A CZ   1 
ATOM   2650 H H    . PHE A 1 185 ? -17.85563 18.43682  -9.91225  1.000 31.64232 ? 365 PHE A H    1 
ATOM   2651 H HA   . PHE A 1 185 ? -16.27511 16.52805  -8.80774  1.000 23.46094 ? 365 PHE A HA   1 
ATOM   2652 H HB2  . PHE A 1 185 ? -15.83535 19.31918  -8.68656  1.000 21.07322 ? 365 PHE A HB2  1 
ATOM   2653 H HB3  . PHE A 1 185 ? -14.95433 18.24800  -7.91080  1.000 21.07322 ? 365 PHE A HB3  1 
ATOM   2654 H HD1  . PHE A 1 185 ? -13.33900 16.90664  -9.13741  1.000 27.17191 ? 365 PHE A HD1  1 
ATOM   2655 H HD2  . PHE A 1 185 ? -15.42490 19.76721  -10.99158 1.000 28.12391 ? 365 PHE A HD2  1 
ATOM   2656 H HE1  . PHE A 1 185 ? -11.89797 16.79120  -10.93320 1.000 17.81488 ? 365 PHE A HE1  1 
ATOM   2657 H HE2  . PHE A 1 185 ? -13.98723 19.65544  -12.78781 1.000 19.80630 ? 365 PHE A HE2  1 
ATOM   2658 H HZ   . PHE A 1 185 ? -12.21514 18.17446  -12.75930 1.000 24.80985 ? 365 PHE A HZ   1 
ATOM   2659 N N    . PHE A 1 186 ? -17.20210 16.75440  -6.48885  1.000 19.26193 ? 366 PHE A N    1 
ATOM   2660 C CA   . PHE A 1 186 ? -17.77938 17.02602  -5.17596  1.000 19.44347 ? 366 PHE A CA   1 
ATOM   2661 C C    . PHE A 1 186 ? -17.02520 16.25711  -4.10151  1.000 19.12231 ? 366 PHE A C    1 
ATOM   2662 O O    . PHE A 1 186 ? -16.48384 15.18122  -4.35590  1.000 19.92345 ? 366 PHE A O    1 
ATOM   2663 C CB   . PHE A 1 186 ? -19.27918 16.68922  -5.13073  1.000 20.86292 ? 366 PHE A CB   1 
ATOM   2664 C CG   . PHE A 1 186 ? -19.60151 15.24284  -5.40027  1.000 21.25778 ? 366 PHE A CG   1 
ATOM   2665 C CD1  . PHE A 1 186 ? -19.81378 14.79329  -6.69360  1.000 22.53164 ? 366 PHE A CD1  1 
ATOM   2666 C CD2  . PHE A 1 186 ? -19.72049 14.34033  -4.35633  1.000 21.80798 ? 366 PHE A CD2  1 
ATOM   2667 C CE1  . PHE A 1 186 ? -20.12154 13.46635  -6.94179  1.000 23.41064 ? 366 PHE A CE1  1 
ATOM   2668 C CE2  . PHE A 1 186 ? -20.02853 13.01155  -4.59760  1.000 22.34970 ? 366 PHE A CE2  1 
ATOM   2669 C CZ   . PHE A 1 186 ? -20.23037 12.57482  -5.89171  1.000 23.44231 ? 366 PHE A CZ   1 
ATOM   2670 H H    . PHE A 1 186 ? -16.70981 16.05119  -6.54141  1.000 23.56636 ? 366 PHE A H    1 
ATOM   2671 H HA   . PHE A 1 186 ? -17.67165 17.97068  -4.98384  1.000 22.97630 ? 366 PHE A HA   1 
ATOM   2672 H HB2  . PHE A 1 186 ? -19.61820 16.90552  -4.24802  1.000 22.77526 ? 366 PHE A HB2  1 
ATOM   2673 H HB3  . PHE A 1 186 ? -19.73591 17.22116  -5.80106  1.000 22.77526 ? 366 PHE A HB3  1 
ATOM   2674 H HD1  . PHE A 1 186 ? -19.74874 15.39022  -7.40377  1.000 27.49001 ? 366 PHE A HD1  1 
ATOM   2675 H HD2  . PHE A 1 186 ? -19.59189 14.63023  -3.48208  1.000 23.90934 ? 366 PHE A HD2  1 
ATOM   2676 H HE1  . PHE A 1 186 ? -20.25496 13.17521  -7.81491  1.000 28.54482 ? 366 PHE A HE1  1 
ATOM   2677 H HE2  . PHE A 1 186 ? -20.09934 12.41407  -3.88844  1.000 24.55939 ? 366 PHE A HE2  1 
ATOM   2678 H HZ   . PHE A 1 186 ? -20.43888 11.68354  -6.05612  1.000 28.58282 ? 366 PHE A HZ   1 
ATOM   2679 N N    . TRP A 1 187 ? -17.00028 16.82154  -2.89331  1.000 21.28361 ? 367 TRP A N    1 
ATOM   2680 C CA   . TRP A 1 187 ? -16.35291 16.14303  -1.77760  1.000 19.37317 ? 367 TRP A CA   1 
ATOM   2681 C C    . TRP A 1 187 ? -16.97571 14.76600  -1.58390  1.000 20.18257 ? 367 TRP A C    1 
ATOM   2682 O O    . TRP A 1 187 ? -18.20191 14.62124  -1.57636  1.000 21.32049 ? 367 TRP A O    1 
ATOM   2683 C CB   . TRP A 1 187 ? -16.48404 16.95509  -0.48757  1.000 19.99807 ? 367 TRP A CB   1 
ATOM   2684 C CG   . TRP A 1 187 ? -15.96206 18.36325  -0.54648  1.000 20.98232 ? 367 TRP A CG   1 
ATOM   2685 C CD1  . TRP A 1 187 ? -16.60153 19.48379  -0.10587  1.000 24.07131 ? 367 TRP A CD1  1 
ATOM   2686 C CD2  . TRP A 1 187 ? -14.69400 18.80096  -1.05695  1.000 19.10603 ? 367 TRP A CD2  1 
ATOM   2687 N NE1  . TRP A 1 187 ? -15.81637 20.59156  -0.31179  1.000 20.80765 ? 367 TRP A NE1  1 
ATOM   2688 C CE2  . TRP A 1 187 ? -14.64132 20.20081  -0.89668  1.000 22.34980 ? 367 TRP A CE2  1 
ATOM   2689 C CE3  . TRP A 1 187 ? -13.60199 18.14803  -1.63599  1.000 26.02412 ? 367 TRP A CE3  1 
ATOM   2690 C CZ2  . TRP A 1 187 ? -13.54128 20.95838  -1.29462  1.000 17.50547 ? 367 TRP A CZ2  1 
ATOM   2691 C CZ3  . TRP A 1 187 ? -12.51016 18.90350  -2.03120  1.000 23.97795 ? 367 TRP A CZ3  1 
ATOM   2692 C CH2  . TRP A 1 187 ? -12.48861 20.29269  -1.85805  1.000 22.35544 ? 367 TRP A CH2  1 
ATOM   2693 H H    . TRP A 1 187 ? -17.34610 17.58457  -2.69889  1.000 25.99238 ? 367 TRP A H    1 
ATOM   2694 H HA   . TRP A 1 187 ? -15.40724 16.04851  -1.97172  1.000 20.98756 ? 367 TRP A HA   1 
ATOM   2695 H HB2  . TRP A 1 187 ? -17.42429 17.00659  -0.25480  1.000 21.73744 ? 367 TRP A HB2  1 
ATOM   2696 H HB3  . TRP A 1 187 ? -15.99372 16.49584  0.21213   1.000 21.73744 ? 367 TRP A HB3  1 
ATOM   2697 H HD1  . TRP A 1 187 ? -17.44808 19.49622  0.27897   1.000 29.33762 ? 367 TRP A HD1  1 
ATOM   2698 H HE1  . TRP A 1 187 ? -16.02819 21.39945  -0.10675  1.000 25.42122 ? 367 TRP A HE1  1 
ATOM   2699 H HE3  . TRP A 1 187 ? -13.60834 17.22551  -1.75348  1.000 31.68099 ? 367 TRP A HE3  1 
ATOM   2700 H HZ2  . TRP A 1 187 ? -13.52404 21.88128  -1.18122  1.000 19.38327 ? 367 TRP A HZ2  1 
ATOM   2701 H HZ3  . TRP A 1 187 ? -11.77822 18.48027  -2.41855  1.000 29.22558 ? 367 TRP A HZ3  1 
ATOM   2702 H HH2  . TRP A 1 187 ? -11.74129 20.77340  -2.13253  1.000 27.27858 ? 367 TRP A HH2  1 
ATOM   2703 N N    . SER A 1 188 ? -16.12418 13.75233  -1.42155  1.000 20.63008 ? 368 SER A N    1 
ATOM   2704 C CA   . SER A 1 188 ? -16.59864 12.37853  -1.31528  1.000 20.56249 ? 368 SER A CA   1 
ATOM   2705 C C    . SER A 1 188 ? -17.08883 12.01771  0.08126   1.000 22.80223 ? 368 SER A C    1 
ATOM   2706 O O    . SER A 1 188 ? -17.77972 11.00438  0.23410   1.000 23.76986 ? 368 SER A O    1 
ATOM   2707 C CB   . SER A 1 188 ? -15.48501 11.40826  -1.71829  1.000 19.81822 ? 368 SER A CB   1 
ATOM   2708 O OG   . SER A 1 188 ? -14.77515 11.88062  -2.84876  1.000 18.68774 ? 368 SER A OG   1 
ATOM   2709 H H    . SER A 1 188 ? -15.26980 13.83614  -1.37037  1.000 25.20815 ? 368 SER A H    1 
ATOM   2710 H HA   . SER A 1 188 ? -17.34273 12.26877  -1.92780  1.000 22.41474 ? 368 SER A HA   1 
ATOM   2711 H HB2  . SER A 1 188 ? -14.86713 11.31403  -0.97651  1.000 21.52162 ? 368 SER A HB2  1 
ATOM   2712 H HB3  . SER A 1 188 ? -15.87997 10.54856  -1.93234  1.000 21.52162 ? 368 SER A HB3  1 
ATOM   2713 H HG   . SER A 1 188 ? -15.29544 11.95570  -3.50395  1.000 22.13934 ? 368 SER A HG   1 
ATOM   2714 N N    . ASP A 1 189 ? -16.76427 12.81600  1.09441   1.000 21.78410 ? 369 ASP A N    1 
ATOM   2715 C CA   . ASP A 1 189 ? -17.06163 12.45345  2.47364   1.000 22.99659 ? 369 ASP A CA   1 
ATOM   2716 C C    . ASP A 1 189 ? -18.52912 12.74923  2.78788   1.000 27.87153 ? 369 ASP A C    1 
ATOM   2717 O O    . ASP A 1 189 ? -19.34066 13.02875  1.90092   1.000 24.65559 ? 369 ASP A O    1 
ATOM   2718 C CB   . ASP A 1 189 ? -16.10580 13.17252  3.42428   1.000 28.09775 ? 369 ASP A CB   1 
ATOM   2719 C CG   . ASP A 1 189 ? -16.25681 14.68239  3.38314   1.000 29.78959 ? 369 ASP A CG   1 
ATOM   2720 O OD1  . ASP A 1 189 ? -17.15500 15.18125  2.67291   1.000 29.05185 ? 369 ASP A OD1  1 
ATOM   2721 O OD2  . ASP A 1 189 ? -15.46921 15.37142  4.06539   1.000 22.02723 ? 369 ASP A OD2  1 
ATOM   2722 H H    . ASP A 1 189 ? -16.36991 13.57527  1.00729   1.000 25.09718 ? 369 ASP A H    1 
ATOM   2723 H HA   . ASP A 1 189 ? -16.92514 11.49786  2.56906   1.000 27.16926 ? 369 ASP A HA   1 
ATOM   2724 H HB2  . ASP A 1 189 ? -16.28265 12.87860  4.33160   1.000 34.16935 ? 369 ASP A HB2  1 
ATOM   2725 H HB3  . ASP A 1 189 ? -15.19304 12.95613  3.17741   1.000 34.16935 ? 369 ASP A HB3  1 
ATOM   2726 N N    . ARG A 1 190 ? -18.88051 12.69984  4.07514   1.000 25.78907 ? 370 ARG A N    1 
ATOM   2727 C CA   . ARG A 1 190 ? -20.27115 12.80619  4.50017   1.000 27.54556 ? 370 ARG A CA   1 
ATOM   2728 C C    . ARG A 1 190 ? -20.88831 14.16253  4.19770   1.000 27.67181 ? 370 ARG A C    1 
ATOM   2729 O O    . ARG A 1 190 ? -22.10304 14.31587  4.35997   1.000 29.60782 ? 370 ARG A O    1 
ATOM   2730 C CB   . ARG A 1 190 ? -20.38858 12.53271  5.99963   1.000 28.99444 ? 370 ARG A CB   1 
ATOM   2731 C CG   . ARG A 1 190 ? -19.81752 11.20132  6.43727   1.000 38.10921 ? 370 ARG A CG   1 
ATOM   2732 C CD   . ARG A 1 190 ? -19.36287 11.24769  7.88166   1.000 40.49281 ? 370 ARG A CD   1 
ATOM   2733 N NE   . ARG A 1 190 ? -19.18996 9.90519   8.41860   1.000 53.84816 ? 370 ARG A NE   1 
ATOM   2734 C CZ   . ARG A 1 190 ? -20.18366 9.13418   8.83755   1.000 37.60825 ? 370 ARG A CZ   1 
ATOM   2735 N NH1  . ARG A 1 190 ? -21.43935 9.55198   8.82144   1.000 44.56404 ? 370 ARG A NH1  1 
ATOM   2736 N NH2  . ARG A 1 190 ? -19.91179 7.91140   9.27892   1.000 45.25880 ? 370 ARG A NH2  1 
ATOM   2737 H H    . ARG A 1 190 ? -18.32548 12.60441  4.72509   1.000 28.68664 ? 370 ARG A H    1 
ATOM   2738 H HA   . ARG A 1 190 ? -20.77907 12.13115  4.02348   1.000 31.43236 ? 370 ARG A HA   1 
ATOM   2739 H HB2  . ARG A 1 190 ? -19.91248 13.22844  6.47940   1.000 32.53308 ? 370 ARG A HB2  1 
ATOM   2740 H HB3  . ARG A 1 190 ? -21.32728 12.54416  6.24379   1.000 32.53308 ? 370 ARG A HB3  1 
ATOM   2741 H HG2  . ARG A 1 190 ? -20.49794 10.51521  6.35251   1.000 46.18311 ? 370 ARG A HG2  1 
ATOM   2742 H HG3  . ARG A 1 190 ? -19.05290 10.98058  5.88271   1.000 46.18311 ? 370 ARG A HG3  1 
ATOM   2743 H HD2  . ARG A 1 190 ? -18.51342 11.71264  7.93798   1.000 49.04342 ? 370 ARG A HD2  1 
ATOM   2744 H HD3  . ARG A 1 190 ? -20.02921 11.70830  8.41525   1.000 49.04342 ? 370 ARG A HD3  1 
ATOM   2745 H HE   . ARG A 1 190 ? -18.39054 9.59187   8.46713   1.000 65.06984 ? 370 ARG A HE   1 
ATOM   2746 H HH11 . ARG A 1 190 ? -21.62643 10.34076  8.53433   1.000 53.92889 ? 370 ARG A HH11 1 
ATOM   2747 H HH12 . ARG A 1 190 ? -22.06822 9.03469   9.09807   1.000 53.92889 ? 370 ARG A HH12 1 
ATOM   2748 H HH21 . ARG A 1 190 ? -19.09953 7.62908   9.29035   1.000 54.76260 ? 370 ARG A HH21 1 
ATOM   2749 H HH22 . ARG A 1 190 ? -20.54800 7.40193   9.55328   1.000 54.76260 ? 370 ARG A HH22 1 
ATOM   2750 N N    . ARG A 1 191 ? -20.09103 15.15036  3.79232   1.000 26.86125 ? 371 ARG A N    1 
ATOM   2751 C CA   . ARG A 1 191 ? -20.65065 16.45123  3.45273   1.000 35.79929 ? 371 ARG A CA   1 
ATOM   2752 C C    . ARG A 1 191 ? -21.57844 16.38213  2.24727   1.000 29.25385 ? 371 ARG A C    1 
ATOM   2753 O O    . ARG A 1 191 ? -22.41383 17.27617  2.07319   1.000 40.94416 ? 371 ARG A O    1 
ATOM   2754 C CB   . ARG A 1 191 ? -19.52425 17.44865  3.18348   1.000 41.03731 ? 371 ARG A CB   1 
ATOM   2755 C CG   . ARG A 1 191 ? -18.77730 17.88458  4.43216   1.000 31.04459 ? 371 ARG A CG   1 
ATOM   2756 C CD   . ARG A 1 191 ? -17.63139 18.82300  4.09134   1.000 35.75123 ? 371 ARG A CD   1 
ATOM   2757 N NE   . ARG A 1 191 ? -16.59589 18.16018  3.30734   1.000 29.53121 ? 371 ARG A NE   1 
ATOM   2758 C CZ   . ARG A 1 191 ? -15.44656 18.72077  2.95593   1.000 38.79494 ? 371 ARG A CZ   1 
ATOM   2759 N NH1  . ARG A 1 191 ? -15.15004 19.96416  3.29810   1.000 30.21417 ? 371 ARG A NH1  1 
ATOM   2760 N NH2  . ARG A 1 191 ? -14.57281 18.01628  2.24223   1.000 44.86356 ? 371 ARG A NH2  1 
ATOM   2761 H H    . ARG A 1 191 ? -19.23722 15.09195  3.70756   1.000 32.68555 ? 371 ARG A H    1 
ATOM   2762 H HA   . ARG A 1 191 ? -21.16663 16.77443  4.20784   1.000 43.41120 ? 371 ARG A HA   1 
ATOM   2763 H HB2  . ARG A 1 191 ? -18.88223 17.03856  2.58303   1.000 49.69682 ? 371 ARG A HB2  1 
ATOM   2764 H HB3  . ARG A 1 191 ? -19.90246 18.24205  2.77316   1.000 49.69682 ? 371 ARG A HB3  1 
ATOM   2765 H HG2  . ARG A 1 191 ? -19.38697 18.34982  5.02610   1.000 37.70555 ? 371 ARG A HG2  1 
ATOM   2766 H HG3  . ARG A 1 191 ? -18.41127 17.10432  4.87727   1.000 37.70555 ? 371 ARG A HG3  1 
ATOM   2767 H HD2  . ARG A 1 191 ? -17.97290 19.56848  3.57314   1.000 43.35353 ? 371 ARG A HD2  1 
ATOM   2768 H HD3  . ARG A 1 191 ? -17.22896 19.14649  4.91250   1.000 43.35353 ? 371 ARG A HD3  1 
ATOM   2769 H HE   . ARG A 1 191 ? -16.74033 17.35061  3.05570   1.000 35.88950 ? 371 ARG A HE   1 
ATOM   2770 H HH11 . ARG A 1 191 ? -15.70855 20.42816  3.75894   1.000 36.70905 ? 371 ARG A HH11 1 
ATOM   2771 H HH12 . ARG A 1 191 ? -14.39882 20.30826  3.05963   1.000 36.70905 ? 371 ARG A HH12 1 
ATOM   2772 H HH21 . ARG A 1 191 ? -14.75641 17.20760  2.01434   1.000 54.28832 ? 371 ARG A HH21 1 
ATOM   2773 H HH22 . ARG A 1 191 ? -13.82427 18.36945  2.00865   1.000 54.28832 ? 371 ARG A HH22 1 
ATOM   2774 N N    . ASN A 1 192 ? -21.45997 15.34569  1.41747   1.000 26.16512 ? 372 ASN A N    1 
ATOM   2775 C CA   . ASN A 1 192 ? -22.23676 15.22350  0.18436   1.000 26.32557 ? 372 ASN A CA   1 
ATOM   2776 C C    . ASN A 1 192 ? -22.87207 13.84209  0.08758   1.000 28.15856 ? 372 ASN A C    1 
ATOM   2777 O O    . ASN A 1 192 ? -22.46338 13.01142  -0.73254  1.000 32.00113 ? 372 ASN A O    1 
ATOM   2778 C CB   . ASN A 1 192 ? -21.35879 15.49422  -1.03862  1.000 32.15232 ? 372 ASN A CB   1 
ATOM   2779 C CG   . ASN A 1 192 ? -21.02984 16.96114  -1.20441  1.000 28.68653 ? 372 ASN A CG   1 
ATOM   2780 O OD1  . ASN A 1 192 ? -21.83787 17.82912  -0.87696  1.000 31.87437 ? 372 ASN A OD1  1 
ATOM   2781 N ND2  . ASN A 1 192 ? -19.84013 17.24699  -1.72027  1.000 22.58773 ? 372 ASN A ND2  1 
ATOM   2782 H H    . ASN A 1 192 ? -20.92401 14.68653  1.55104   1.000 29.13790 ? 372 ASN A H    1 
ATOM   2783 H HA   . ASN A 1 192 ? -22.95528 15.87434  0.21656   1.000 30.88107 ? 372 ASN A HA   1 
ATOM   2784 H HB2  . ASN A 1 192 ? -20.52486 15.00795  -0.94375  1.000 39.03483 ? 372 ASN A HB2  1 
ATOM   2785 H HB3  . ASN A 1 192 ? -21.82617 15.19897  -1.83567  1.000 39.03483 ? 372 ASN A HB3  1 
ATOM   2786 H HD21 . ASN A 1 192 ? -19.60660 18.06678  -1.83428  1.000 24.84504 ? 372 ASN A HD21 1 
ATOM   2787 H HD22 . ASN A 1 192 ? -19.30314 16.61232  -1.94037  1.000 24.84504 ? 372 ASN A HD22 1 
ATOM   2788 N N    . PRO A 1 193 ? -23.88137 13.56150  0.90954   1.000 31.61048 ? 373 PRO A N    1 
ATOM   2789 C CA   . PRO A 1 193 ? -24.73401 12.40177  0.63169   1.000 30.20491 ? 373 PRO A CA   1 
ATOM   2790 C C    . PRO A 1 193 ? -25.42117 12.60146  -0.70793  1.000 30.25166 ? 373 PRO A C    1 
ATOM   2791 O O    . PRO A 1 193 ? -25.71088 13.72728  -1.11268  1.000 30.14299 ? 373 PRO A O    1 
ATOM   2792 C CB   . PRO A 1 193 ? -25.73812 12.39599  1.79088   1.000 36.15987 ? 373 PRO A CB   1 
ATOM   2793 C CG   . PRO A 1 193 ? -25.17172 13.31314  2.82720   1.000 35.29538 ? 373 PRO A CG   1 
ATOM   2794 C CD   . PRO A 1 193 ? -24.32336 14.30581  2.09999   1.000 30.20770 ? 373 PRO A CD   1 
ATOM   2795 H HA   . PRO A 1 193 ? -24.23824 11.56822  0.64925   1.000 35.65193 ? 373 PRO A HA   1 
ATOM   2796 H HB2  . PRO A 1 193 ? -26.59832 12.71840  1.47943   1.000 43.84389 ? 373 PRO A HB2  1 
ATOM   2797 H HB3  . PRO A 1 193 ? -25.82806 11.49568  2.14055   1.000 43.84389 ? 373 PRO A HB3  1 
ATOM   2798 H HG2  . PRO A 1 193 ? -25.89468 13.76010  3.29459   1.000 42.80650 ? 373 PRO A HG2  1 
ATOM   2799 H HG3  . PRO A 1 193 ? -24.63673 12.80233  3.45470   1.000 42.80650 ? 373 PRO A HG3  1 
ATOM   2800 H HD2  . PRO A 1 193 ? -24.84282 15.08505  1.84728   1.000 33.98900 ? 373 PRO A HD2  1 
ATOM   2801 H HD3  . PRO A 1 193 ? -23.56451 14.57424  2.64127   1.000 33.98900 ? 373 PRO A HD3  1 
ATOM   2802 N N    . HIS A 1 194 ? -25.66032 11.50586  -1.41902  1.000 30.51479 ? 374 HIS A N    1 
ATOM   2803 C CA   . HIS A 1 194 ? -26.27087 11.64833  -2.73192  1.000 32.16364 ? 374 HIS A CA   1 
ATOM   2804 C C    . HIS A 1 194 ? -26.97276 10.36051  -3.12514  1.000 35.00685 ? 374 HIS A C    1 
ATOM   2805 O O    . HIS A 1 194 ? -26.70976 9.28663   -2.57857  1.000 32.20691 ? 374 HIS A O    1 
ATOM   2806 C CB   . HIS A 1 194 ? -25.23364 12.04168  -3.79015  1.000 28.74631 ? 374 HIS A CB   1 
ATOM   2807 C CG   . HIS A 1 194 ? -24.04151 11.13911  -3.83358  1.000 27.57145 ? 374 HIS A CG   1 
ATOM   2808 N ND1  . HIS A 1 194 ? -23.04822 11.17323  -2.87897  1.000 26.76284 ? 374 HIS A ND1  1 
ATOM   2809 C CD2  . HIS A 1 194 ? -23.67900 10.18234  -4.72019  1.000 28.74356 ? 374 HIS A CD2  1 
ATOM   2810 C CE1  . HIS A 1 194 ? -22.12714 10.27339  -3.17321  1.000 28.33986 ? 374 HIS A CE1  1 
ATOM   2811 N NE2  . HIS A 1 194 ? -22.48566 9.65875   -4.28592  1.000 27.85613 ? 374 HIS A NE2  1 
ATOM   2812 H H    . HIS A 1 194 ? -25.48473 10.70101  -1.17204  1.000 34.35750 ? 374 HIS A H    1 
ATOM   2813 H HA   . HIS A 1 194 ? -26.94779 12.34129  -2.68202  1.000 39.04842 ? 374 HIS A HA   1 
ATOM   2814 H HB2  . HIS A 1 194 ? -25.65497 12.01719  -4.66352  1.000 34.71935 ? 374 HIS A HB2  1 
ATOM   2815 H HB3  . HIS A 1 194 ? -24.91837 12.93887  -3.59893  1.000 34.71935 ? 374 HIS A HB3  1 
ATOM   2816 H HD1  . HIS A 1 194 ? -23.03078 11.69832  -2.19811  1.000 31.65986 ? 374 HIS A HD1  1 
ATOM   2817 H HD2  . HIS A 1 194 ? -24.14969 9.92740   -5.48069  1.000 34.94432 ? 374 HIS A HD2  1 
ATOM   2818 H HE1  . HIS A 1 194 ? -21.35716 10.10180  -2.68067  1.000 34.45988 ? 374 HIS A HE1  1 
ATOM   2819 N N    . GLU A 1 195 ? -27.87805 10.49856  -4.08849  1.000 32.92265 ? 375 GLU A N    1 
ATOM   2820 C CA   . GLU A 1 195 ? -28.66071 9.38653   -4.59943  1.000 36.24628 ? 375 GLU A CA   1 
ATOM   2821 C C    . GLU A 1 195 ? -28.78868 9.51914   -6.10867  1.000 43.89567 ? 375 GLU A C    1 
ATOM   2822 O O    . GLU A 1 195 ? -28.81044 10.62748  -6.65200  1.000 36.64277 ? 375 GLU A O    1 
ATOM   2823 C CB   . GLU A 1 195 ? -30.05588 9.34285   -3.96596  1.000 36.29058 ? 375 GLU A CB   1 
ATOM   2824 C CG   . GLU A 1 195 ? -30.99141 10.41484  -4.50056  1.000 37.04840 ? 375 GLU A CG   1 
ATOM   2825 C CD   . GLU A 1 195 ? -32.19820 10.64519  -3.61486  1.000 45.81441 ? 375 GLU A CD   1 
ATOM   2826 O OE1  . GLU A 1 195 ? -32.12395 10.34324  -2.40469  1.000 39.79833 ? 375 GLU A OE1  1 
ATOM   2827 O OE2  . GLU A 1 195 ? -33.22539 11.12759  -4.13567  1.000 45.72706 ? 375 GLU A OE2  1 
ATOM   2828 H H    . GLU A 1 195 ? -28.05971 11.24743  -4.47031  1.000 39.95923 ? 375 GLU A H    1 
ATOM   2829 H HA   . GLU A 1 195 ? -28.20772 8.55208   -4.40092  1.000 43.94758 ? 375 GLU A HA   1 
ATOM   2830 H HB2  . GLU A 1 195 ? -30.45672 8.47874   -4.14914  1.000 41.28845 ? 375 GLU A HB2  1 
ATOM   2831 H HB3  . GLU A 1 195 ? -29.96992 9.47241   -3.00850  1.000 41.28845 ? 375 GLU A HB3  1 
ATOM   2832 H HG2  . GLU A 1 195 ? -30.50578 11.25188  -4.56712  1.000 43.08494 ? 375 GLU A HG2  1 
ATOM   2833 H HG3  . GLU A 1 195 ? -31.31066 10.14598  -5.37617  1.000 43.08494 ? 375 GLU A HG3  1 
ATOM   2834 N N    . VAL A 1 196 ? -28.87074 8.37583   -6.78029  1.000 38.35643 ? 376 VAL A N    1 
ATOM   2835 C CA   . VAL A 1 196 ? -29.14333 8.31540   -8.21090  1.000 34.23693 ? 376 VAL A CA   1 
ATOM   2836 C C    . VAL A 1 196 ? -30.60661 7.91279   -8.34803  1.000 36.51627 ? 376 VAL A C    1 
ATOM   2837 O O    . VAL A 1 196 ? -30.96278 6.74535   -8.16651  1.000 37.72361 ? 376 VAL A O    1 
ATOM   2838 C CB   . VAL A 1 196 ? -28.21283 7.33654   -8.93151  1.000 33.38451 ? 376 VAL A CB   1 
ATOM   2839 C CG1  . VAL A 1 196 ? -28.57515 7.25038   -10.40892 1.000 33.80120 ? 376 VAL A CG1  1 
ATOM   2840 C CG2  . VAL A 1 196 ? -26.75982 7.75444   -8.75707  1.000 39.17998 ? 376 VAL A CG2  1 
ATOM   2841 H H    . VAL A 1 196 ? -28.76940 7.60202   -6.41898  1.000 46.47976 ? 376 VAL A H    1 
ATOM   2842 H HA   . VAL A 1 196 ? -29.01751 9.19291   -8.60467  1.000 38.82407 ? 376 VAL A HA   1 
ATOM   2843 H HB   . VAL A 1 196 ? -28.32015 6.45484   -8.54165  1.000 37.80117 ? 376 VAL A HB   1 
ATOM   2844 H HG11 . VAL A 1 196 ? -27.87493 6.77055   -10.87833 1.000 38.30120 ? 376 VAL A HG11 1 
ATOM   2845 H HG12 . VAL A 1 196 ? -29.41786 6.77883   -10.50043 1.000 38.30120 ? 376 VAL A HG12 1 
ATOM   2846 H HG13 . VAL A 1 196 ? -28.65795 8.14820   -10.76664 1.000 38.30120 ? 376 VAL A HG13 1 
ATOM   2847 H HG21 . VAL A 1 196 ? -26.19317 7.13953   -9.24868  1.000 47.46803 ? 376 VAL A HG21 1 
ATOM   2848 H HG22 . VAL A 1 196 ? -26.64677 8.65468   -9.10012  1.000 47.46803 ? 376 VAL A HG22 1 
ATOM   2849 H HG23 . VAL A 1 196 ? -26.53504 7.72924   -7.81381  1.000 47.46803 ? 376 VAL A HG23 1 
ATOM   2850 N N    . GLN A 1 197 ? -31.46101 8.88012   -8.66539  1.000 38.19358 ? 377 GLN A N    1 
ATOM   2851 C CA   . GLN A 1 197 ? -32.88330 8.60290   -8.75485  1.000 39.56886 ? 377 GLN A CA   1 
ATOM   2852 C C    . GLN A 1 197 ? -33.15593 7.63548   -9.90637  1.000 42.57462 ? 377 GLN A C    1 
ATOM   2853 O O    . GLN A 1 197 ? -32.37172 7.55322   -10.85529 1.000 47.46859 ? 377 GLN A O    1 
ATOM   2854 C CB   . GLN A 1 197 ? -33.66861 9.89602   -8.95117  1.000 46.93023 ? 377 GLN A CB   1 
ATOM   2855 C CG   . GLN A 1 197 ? -33.52081 10.87473  -7.79515  1.000 40.34007 ? 377 GLN A CG   1 
ATOM   2856 C CD   . GLN A 1 197 ? -34.35396 12.12736  -7.97443  1.000 42.82109 ? 377 GLN A CD   1 
ATOM   2857 O OE1  . GLN A 1 197 ? -34.68314 12.51358  -9.09596  1.000 41.02791 ? 377 GLN A OE1  1 
ATOM   2858 N NE2  . GLN A 1 197 ? -34.70131 12.76954  -6.86503  1.000 41.51866 ? 377 GLN A NE2  1 
ATOM   2859 H H    . GLN A 1 197 ? -31.24263 9.69523   -8.83126  1.000 46.28434 ? 377 GLN A H    1 
ATOM   2860 H HA   . GLN A 1 197 ? -33.19256 8.19122   -7.93279  1.000 45.22239 ? 377 GLN A HA   1 
ATOM   2861 H HB2  . GLN A 1 197 ? -33.35182 10.33568  -9.75569  1.000 56.76832 ? 377 GLN A HB2  1 
ATOM   2862 H HB3  . GLN A 1 197 ? -34.61013 9.68018   -9.03986  1.000 56.76832 ? 377 GLN A HB3  1 
ATOM   2863 H HG2  . GLN A 1 197 ? -33.80517 10.44062  -6.97564  1.000 48.86014 ? 377 GLN A HG2  1 
ATOM   2864 H HG3  . GLN A 1 197 ? -32.59085 11.14118  -7.72401  1.000 48.86014 ? 377 GLN A HG3  1 
ATOM   2865 H HE21 . GLN A 1 197 ? -34.45321 12.46877  -6.09849  1.000 47.56215 ? 377 GLN A HE21 1 
ATOM   2866 H HE22 . GLN A 1 197 ? -35.17433 13.48615  -6.91319  1.000 47.56215 ? 377 GLN A HE22 1 
ATOM   2867 N N    . PRO A 1 198 ? -34.25398 6.88223   -9.83712  1.000 42.51005 ? 378 PRO A N    1 
ATOM   2868 C CA   . PRO A 1 198 ? -34.49888 5.83792   -10.83811 1.000 49.79024 ? 378 PRO A CA   1 
ATOM   2869 C C    . PRO A 1 198 ? -34.32156 6.34854   -12.26066 1.000 42.79295 ? 378 PRO A C    1 
ATOM   2870 O O    . PRO A 1 198 ? -34.77303 7.43982   -12.61374 1.000 49.18158 ? 378 PRO A O    1 
ATOM   2871 C CB   . PRO A 1 198 ? -35.95112 5.42402   -10.57200 1.000 46.14751 ? 378 PRO A CB   1 
ATOM   2872 C CG   . PRO A 1 198 ? -36.27835 5.90606   -9.18594  1.000 52.94831 ? 378 PRO A CG   1 
ATOM   2873 C CD   . PRO A 1 198 ? -35.14805 6.75159   -8.67472  1.000 44.25377 ? 378 PRO A CD   1 
ATOM   2874 H HA   . PRO A 1 198 ? -33.90152 5.08857   -10.68797 1.000 60.20034 ? 378 PRO A HA   1 
ATOM   2875 H HB2  . PRO A 1 198 ? -36.53318 5.84132   -11.22620 1.000 53.11677 ? 378 PRO A HB2  1 
ATOM   2876 H HB3  . PRO A 1 198 ? -36.02921 4.45870   -10.62638 1.000 53.11677 ? 378 PRO A HB3  1 
ATOM   2877 H HG2  . PRO A 1 198 ? -37.09374 6.43025   -9.22133  1.000 63.99002 ? 378 PRO A HG2  1 
ATOM   2878 H HG3  . PRO A 1 198 ? -36.40332 5.13675   -8.60849  1.000 63.99002 ? 378 PRO A HG3  1 
ATOM   2879 H HD2  . PRO A 1 198 ? -35.47093 7.62099   -8.39048  1.000 53.05414 ? 378 PRO A HD2  1 
ATOM   2880 H HD3  . PRO A 1 198 ? -34.69388 6.30995   -7.94016  1.000 53.05414 ? 378 PRO A HD3  1 
ATOM   2881 N N    . ALA A 1 199 ? -33.65114 5.54171   -13.07768 1.000 42.26115 ? 379 ALA A N    1 
ATOM   2882 C CA   . ALA A 1 199 ? -33.43898 5.83006   -14.48848 1.000 41.88600 ? 379 ALA A CA   1 
ATOM   2883 C C    . ALA A 1 199 ? -34.30365 4.89668   -15.32211 1.000 46.29602 ? 379 ALA A C    1 
ATOM   2884 O O    . ALA A 1 199 ? -34.33036 3.68572   -15.07738 1.000 44.85956 ? 379 ALA A O    1 
ATOM   2885 C CB   . ALA A 1 199 ? -31.96656 5.66459   -14.86885 1.000 39.83386 ? 379 ALA A CB   1 
ATOM   2886 H H    . ALA A 1 199 ? -33.29926 4.79790   -12.82763 1.000 48.45613 ? 379 ALA A H    1 
ATOM   2887 H HA   . ALA A 1 199 ? -33.69896 6.74549   -14.67637 1.000 50.03980 ? 379 ALA A HA   1 
ATOM   2888 H HB1  . ALA A 1 199 ? -31.85972 5.86401   -15.81210 1.000 47.21306 ? 379 ALA A HB1  1 
ATOM   2889 H HB2  . ALA A 1 199 ? -31.43272 6.27690   -14.33877 1.000 47.21306 ? 379 ALA A HB2  1 
ATOM   2890 H HB3  . ALA A 1 199 ? -31.69533 4.75037   -14.69126 1.000 47.21306 ? 379 ALA A HB3  1 
ATOM   2891 N N    . TYR A 1 200 ? -35.01371 5.46228   -16.29671 1.000 44.93303 ? 380 TYR A N    1 
ATOM   2892 C CA   . TYR A 1 200 ? -35.84924 4.69130   -17.20772 1.000 47.03107 ? 380 TYR A CA   1 
ATOM   2893 C C    . TYR A 1 200 ? -35.27514 4.64894   -18.61789 1.000 46.56819 ? 380 TYR A C    1 
ATOM   2894 O O    . TYR A 1 200 ? -35.98477 4.28048   -19.55984 1.000 48.32157 ? 380 TYR A O    1 
ATOM   2895 C CB   . TYR A 1 200 ? -37.26880 5.25831   -17.21111 1.000 50.90744 ? 380 TYR A CB   1 
ATOM   2896 C CG   . TYR A 1 200 ? -37.86455 5.32246   -15.82264 1.000 49.71634 ? 380 TYR A CG   1 
ATOM   2897 C CD1  . TYR A 1 200 ? -38.32779 4.17442   -15.19337 1.000 51.21963 ? 380 TYR A CD1  1 
ATOM   2898 C CD2  . TYR A 1 200 ? -37.94497 6.52527   -15.13281 1.000 52.10541 ? 380 TYR A CD2  1 
ATOM   2899 C CE1  . TYR A 1 200 ? -38.86491 4.22276   -13.92194 1.000 52.02578 ? 380 TYR A CE1  1 
ATOM   2900 C CE2  . TYR A 1 200 ? -38.48163 6.58383   -13.85929 1.000 55.22950 ? 380 TYR A CE2  1 
ATOM   2901 C CZ   . TYR A 1 200 ? -38.93931 5.42891   -13.25926 1.000 51.32198 ? 380 TYR A CZ   1 
ATOM   2902 O OH   . TYR A 1 200 ? -39.47456 5.47976   -11.99270 1.000 59.25593 ? 380 TYR A OH   1 
ATOM   2903 H H    . TYR A 1 200 ? -35.02638 6.30818   -16.45131 1.000 51.65940 ? 380 TYR A H    1 
ATOM   2904 H HA   . TYR A 1 200 ? -35.90357 3.77488   -16.89449 1.000 54.17705 ? 380 TYR A HA   1 
ATOM   2905 H HB2  . TYR A 1 200 ? -37.25054 6.15769   -17.57400 1.000 61.54098 ? 380 TYR A HB2  1 
ATOM   2906 H HB3  . TYR A 1 200 ? -37.83570 4.69160   -17.75734 1.000 61.54098 ? 380 TYR A HB3  1 
ATOM   2907 H HD1  . TYR A 1 200 ? -38.27537 3.35827   -15.63615 1.000 59.20331 ? 380 TYR A HD1  1 
ATOM   2908 H HD2  . TYR A 1 200 ? -37.63282 7.30417   -15.53378 1.000 62.97854 ? 380 TYR A HD2  1 
ATOM   2909 H HE1  . TYR A 1 200 ? -39.17462 3.44585   -13.51526 1.000 60.17069 ? 380 TYR A HE1  1 
ATOM   2910 H HE2  . TYR A 1 200 ? -38.53361 7.39663   -13.41034 1.000 66.72745 ? 380 TYR A HE2  1 
ATOM   2911 H HH   . TYR A 1 200 ? -39.44544 6.26653   -11.69987 1.000 71.55916 ? 380 TYR A HH   1 
ATOM   2912 N N    . ALA A 1 201 ? -34.00776 5.02183   -18.78000 1.000 44.38717 ? 381 ALA A N    1 
ATOM   2913 C CA   . ALA A 1 201 ? -33.27339 4.84303   -20.02218 1.000 43.90959 ? 381 ALA A CA   1 
ATOM   2914 C C    . ALA A 1 201 ? -31.83700 4.48789   -19.66628 1.000 41.92383 ? 381 ALA A C    1 
ATOM   2915 O O    . ALA A 1 201 ? -31.40762 4.63118   -18.51834 1.000 42.38172 ? 381 ALA A O    1 
ATOM   2916 C CB   . ALA A 1 201 ? -33.32898 6.09654   -20.90316 1.000 43.57537 ? 381 ALA A CB   1 
ATOM   2917 H H    . ALA A 1 201 ? -33.53862 5.39297   -18.16213 1.000 52.95474 ? 381 ALA A H    1 
ATOM   2918 H HA   . ALA A 1 201 ? -33.65939 4.11461   -20.53335 1.000 50.43127 ? 381 ALA A HA   1 
ATOM   2919 H HB1  . ALA A 1 201 ? -32.78324 5.95256   -21.69205 1.000 50.03020 ? 381 ALA A HB1  1 
ATOM   2920 H HB2  . ALA A 1 201 ? -34.24927 6.25948   -21.16282 1.000 50.03020 ? 381 ALA A HB2  1 
ATOM   2921 H HB3  . ALA A 1 201 ? -32.98879 6.85219   -20.39902 1.000 50.03020 ? 381 ALA A HB3  1 
ATOM   2922 N N    . THR A 1 202 ? -31.09064 4.00901   -20.65694 1.000 41.70476 ? 382 THR A N    1 
ATOM   2923 C CA   . THR A 1 202 ? -29.69967 3.63828   -20.42570 1.000 40.02104 ? 382 THR A CA   1 
ATOM   2924 C C    . THR A 1 202 ? -28.89748 4.88509   -20.06964 1.000 37.88907 ? 382 THR A C    1 
ATOM   2925 O O    . THR A 1 202 ? -28.79495 5.81667   -20.87449 1.000 39.09730 ? 382 THR A O    1 
ATOM   2926 C CB   . THR A 1 202 ? -29.11903 2.95309   -21.65975 1.000 41.10083 ? 382 THR A CB   1 
ATOM   2927 O OG1  . THR A 1 202 ? -29.89632 1.78953   -21.96978 1.000 49.84563 ? 382 THR A OG1  1 
ATOM   2928 C CG2  . THR A 1 202 ? -27.67425 2.53307   -21.41307 1.000 38.93916 ? 382 THR A CG2  1 
ATOM   2929 H H    . THR A 1 202 ? -31.36360 3.89053   -21.46382 1.000 49.08490 ? 382 THR A H    1 
ATOM   2930 H HA   . THR A 1 202 ? -29.64756 3.01187   -19.68691 1.000 45.76501 ? 382 THR A HA   1 
ATOM   2931 H HB   . THR A 1 202 ? -29.13658 3.57010   -22.40801 1.000 49.77305 ? 382 THR A HB   1 
ATOM   2932 H HG1  . THR A 1 202 ? -29.57847 1.40309   -22.64449 1.000 60.26680 ? 382 THR A HG1  1 
ATOM   2933 H HG21 . THR A 1 202 ? -27.31894 2.08932   -22.19904 1.000 44.46675 ? 382 THR A HG21 1 
ATOM   2934 H HG22 . THR A 1 202 ? -27.13065 3.31264   -21.21896 1.000 44.46675 ? 382 THR A HG22 1 
ATOM   2935 H HG23 . THR A 1 202 ? -27.63002 1.92307   -20.66018 1.000 44.46675 ? 382 THR A HG23 1 
ATOM   2936 N N    . ARG A 1 203 ? -28.32637 4.89927   -18.86685 1.000 38.21008 ? 383 ARG A N    1 
ATOM   2937 C CA   . ARG A 1 203 ? -27.64121 6.06439   -18.31830 1.000 35.06088 ? 383 ARG A CA   1 
ATOM   2938 C C    . ARG A 1 203 ? -26.18690 5.69853   -18.06351 1.000 33.16151 ? 383 ARG A C    1 
ATOM   2939 O O    . ARG A 1 203 ? -25.90427 4.77503   -17.29492 1.000 33.19020 ? 383 ARG A O    1 
ATOM   2940 C CB   . ARG A 1 203 ? -28.32968 6.52031   -17.02874 1.000 41.07603 ? 383 ARG A CB   1 
ATOM   2941 C CG   . ARG A 1 203 ? -27.65929 7.65923   -16.27336 1.000 33.10752 ? 383 ARG A CG   1 
ATOM   2942 C CD   . ARG A 1 203 ? -28.25652 7.76531   -14.87497 1.000 36.39377 ? 383 ARG A CD   1 
ATOM   2943 N NE   . ARG A 1 203 ? -27.82034 8.95198   -14.14825 1.000 32.15722 ? 383 ARG A NE   1 
ATOM   2944 C CZ   . ARG A 1 203 ? -26.67092 9.05597   -13.49480 1.000 30.56384 ? 383 ARG A CZ   1 
ATOM   2945 N NH1  . ARG A 1 203 ? -25.78897 8.07025   -13.48314 1.000 29.99846 ? 383 ARG A NH1  1 
ATOM   2946 N NH2  . ARG A 1 203 ? -26.40037 10.17770  -12.83398 1.000 30.61416 ? 383 ARG A NH2  1 
ATOM   2947 H H    . ARG A 1 203 ? -28.32351 4.22381   -18.33454 1.000 46.30414 ? 383 ARG A H    1 
ATOM   2948 H HA   . ARG A 1 203 ? -27.65632 6.79650   -18.95445 1.000 42.52511 ? 383 ARG A HA   1 
ATOM   2949 H HB2  . ARG A 1 203 ? -29.22609 6.81536   -17.25303 1.000 49.74329 ? 383 ARG A HB2  1 
ATOM   2950 H HB3  . ARG A 1 203 ? -28.37126 5.76266   -16.42448 1.000 49.74329 ? 383 ARG A HB3  1 
ATOM   2951 H HG2  . ARG A 1 203 ? -26.70798 7.48666   -16.19514 1.000 37.46879 ? 383 ARG A HG2  1 
ATOM   2952 H HG3  . ARG A 1 203 ? -27.80732 8.49595   -16.74122 1.000 37.46879 ? 383 ARG A HG3  1 
ATOM   2953 H HD2  . ARG A 1 203 ? -29.22312 7.80032   -14.94824 1.000 44.12457 ? 383 ARG A HD2  1 
ATOM   2954 H HD3  . ARG A 1 203 ? -27.99079 6.98727   -14.36026 1.000 44.12457 ? 383 ARG A HD3  1 
ATOM   2955 H HE   . ARG A 1 203 ? -28.34579 9.63277   -14.14303 1.000 36.48555 ? 383 ARG A HE   1 
ATOM   2956 H HH11 . ARG A 1 203 ? -25.95466 7.34000   -13.90609 1.000 33.73791 ? 383 ARG A HH11 1 
ATOM   2957 H HH12 . ARG A 1 203 ? -25.04988 8.15961   -13.05262 1.000 33.73791 ? 383 ARG A HH12 1 
ATOM   2958 H HH21 . ARG A 1 203 ? -26.96750 10.82420  -12.83395 1.000 37.18904 ? 383 ARG A HH21 1 
ATOM   2959 H HH22 . ARG A 1 203 ? -25.65826 10.25668  -12.40661 1.000 37.18904 ? 383 ARG A HH22 1 
ATOM   2960 N N    . TYR A 1 204 ? -25.27014 6.42655   -18.69467 1.000 31.91921 ? 384 TYR A N    1 
ATOM   2961 C CA   . TYR A 1 204 ? -23.84467 6.15385   -18.59536 1.000 32.35279 ? 384 TYR A CA   1 
ATOM   2962 C C    . TYR A 1 204 ? -23.14670 7.21984   -17.76044 1.000 34.72900 ? 384 TYR A C    1 
ATOM   2963 O O    . TYR A 1 204 ? -23.55106 8.38637   -17.74257 1.000 39.97650 ? 384 TYR A O    1 
ATOM   2964 C CB   . TYR A 1 204 ? -23.19046 6.10247   -19.98001 1.000 30.58572 ? 384 TYR A CB   1 
ATOM   2965 C CG   . TYR A 1 204 ? -23.59878 4.92496   -20.83379 1.000 32.28195 ? 384 TYR A CG   1 
ATOM   2966 C CD1  . TYR A 1 204 ? -23.52435 3.62758   -20.34692 1.000 33.92337 ? 384 TYR A CD1  1 
ATOM   2967 C CD2  . TYR A 1 204 ? -24.04496 5.11178   -22.13461 1.000 33.38709 ? 384 TYR A CD2  1 
ATOM   2968 C CE1  . TYR A 1 204 ? -23.89070 2.54943   -21.12965 1.000 34.63471 ? 384 TYR A CE1  1 
ATOM   2969 C CE2  . TYR A 1 204 ? -24.41386 4.04213   -22.92348 1.000 35.08212 ? 384 TYR A CE2  1 
ATOM   2970 C CZ   . TYR A 1 204 ? -24.33712 2.76403   -22.41666 1.000 37.66019 ? 384 TYR A CZ   1 
ATOM   2971 O OH   . TYR A 1 204 ? -24.70277 1.69985   -23.20663 1.000 37.54586 ? 384 TYR A OH   1 
ATOM   2972 H H    . TYR A 1 204 ? -25.45659 7.09888   -19.19747 1.000 36.04281 ? 384 TYR A H    1 
ATOM   2973 H HA   . TYR A 1 204 ? -23.72539 5.29554   -18.15951 1.000 39.27540 ? 384 TYR A HA   1 
ATOM   2974 H HB2  . TYR A 1 204 ? -23.42953 6.90900   -20.46298 1.000 34.44262 ? 384 TYR A HB2  1 
ATOM   2975 H HB3  . TYR A 1 204 ? -22.22845 6.05814   -19.86392 1.000 34.44262 ? 384 TYR A HB3  1 
ATOM   2976 H HD1  . TYR A 1 204 ? -23.22287 3.48135   -19.47938 1.000 41.16009 ? 384 TYR A HD1  1 
ATOM   2977 H HD2  . TYR A 1 204 ? -24.09612 5.97352   -22.48058 1.000 37.80427 ? 384 TYR A HD2  1 
ATOM   2978 H HE1  . TYR A 1 204 ? -23.83659 1.68502   -20.79087 1.000 39.30141 ? 384 TYR A HE1  1 
ATOM   2979 H HE2  . TYR A 1 204 ? -24.71273 4.18330   -23.79276 1.000 40.42343 ? 384 TYR A HE2  1 
ATOM   2980 H HH   . TYR A 1 204 ? -24.18143 1.05392   -23.07781 1.000 42.79478 ? 384 TYR A HH   1 
ATOM   2981 N N    . ALA A 1 205 ? -22.08789 6.80263   -17.06907 1.000 27.73040 ? 385 ALA A N    1 
ATOM   2982 C CA   . ALA A 1 205 ? -21.22914 7.73312   -16.35215 1.000 28.51869 ? 385 ALA A CA   1 
ATOM   2983 C C    . ALA A 1 205 ? -19.83427 7.13549   -16.24644 1.000 25.17416 ? 385 ALA A C    1 
ATOM   2984 O O    . ALA A 1 205 ? -19.65007 5.91918   -16.33509 1.000 34.06076 ? 385 ALA A O    1 
ATOM   2985 C CB   . ALA A 1 205 ? -21.78160 8.05536   -14.95836 1.000 26.01070 ? 385 ALA A CB   1 
ATOM   2986 H H    . ALA A 1 205 ? -21.84670 5.97994   -17.00115 1.000 31.01623 ? 385 ALA A H    1 
ATOM   2987 H HA   . ALA A 1 205 ? -21.16842 8.56232   -16.85179 1.000 34.67448 ? 385 ALA A HA   1 
ATOM   2988 H HB1  . ALA A 1 205 ? -21.18053 8.67489   -14.51588 1.000 29.15682 ? 385 ALA A HB1  1 
ATOM   2989 H HB2  . ALA A 1 205 ? -22.65991 8.45630   -15.05173 1.000 29.15682 ? 385 ALA A HB2  1 
ATOM   2990 H HB3  . ALA A 1 205 ? -21.84567 7.23397   -14.44639 1.000 29.15682 ? 385 ALA A HB3  1 
ATOM   2991 N N    . ILE A 1 206 ? -18.84729 8.01018   -16.06693 1.000 23.77163 ? 386 ILE A N    1 
ATOM   2992 C CA   . ILE A 1 206 ? -17.46977 7.60614   -15.80856 1.000 27.32511 ? 386 ILE A CA   1 
ATOM   2993 C C    . ILE A 1 206 ? -17.00399 8.35375   -14.56882 1.000 29.60152 ? 386 ILE A C    1 
ATOM   2994 O O    . ILE A 1 206 ? -16.95258 9.58981   -14.56793 1.000 20.99272 ? 386 ILE A O    1 
ATOM   2995 C CB   . ILE A 1 206 ? -16.54265 7.89053   -17.00167 1.000 22.47934 ? 386 ILE A CB   1 
ATOM   2996 C CG1  . ILE A 1 206 ? -17.09893 7.22947   -18.26609 1.000 23.84536 ? 386 ILE A CG1  1 
ATOM   2997 C CG2  . ILE A 1 206 ? -15.13668 7.37577   -16.71747 1.000 21.74806 ? 386 ILE A CG2  1 
ATOM   2998 C CD1  . ILE A 1 206 ? -16.19580 7.34847   -19.47783 1.000 23.80611 ? 386 ILE A CD1  1 
ATOM   2999 H H    . ILE A 1 206 ? -18.95498 8.86307   -16.09109 1.000 28.72153 ? 386 ILE A H    1 
ATOM   3000 H HA   . ILE A 1 206 ? -17.43694 6.65342   -15.62928 1.000 33.24218 ? 386 ILE A HA   1 
ATOM   3001 H HB   . ILE A 1 206 ? -16.50131 8.85008   -17.13758 1.000 24.71496 ? 386 ILE A HB   1 
ATOM   3002 H HG12 . ILE A 1 206 ? -17.23159 6.28492   -18.08963 1.000 27.79397 ? 386 ILE A HG12 1 
ATOM   3003 H HG13 . ILE A 1 206 ? -17.94558 7.64762   -18.48795 1.000 27.79397 ? 386 ILE A HG13 1 
ATOM   3004 H HG21 . ILE A 1 206 ? -14.54646 7.65735   -17.43388 1.000 24.73445 ? 386 ILE A HG21 1 
ATOM   3005 H HG22 . ILE A 1 206 ? -14.83068 7.74268   -15.87329 1.000 24.73445 ? 386 ILE A HG22 1 
ATOM   3006 H HG23 . ILE A 1 206 ? -15.15886 6.40725   -16.66856 1.000 24.73445 ? 386 ILE A HG23 1 
ATOM   3007 H HD11 . ILE A 1 206 ? -16.69529 7.09579   -20.27002 1.000 28.46483 ? 386 ILE A HD11 1 
ATOM   3008 H HD12 . ILE A 1 206 ? -15.89261 8.26648   -19.55679 1.000 28.46483 ? 386 ILE A HD12 1 
ATOM   3009 H HD13 . ILE A 1 206 ? -15.43507 6.75751   -19.36397 1.000 28.46483 ? 386 ILE A HD13 1 
ATOM   3010 N N    . SER A 1 207 ? -16.65647 7.60920   -13.52391 1.000 28.06812 ? 387 SER A N    1 
ATOM   3011 C CA   . SER A 1 207 ? -16.34624 8.17709   -12.22265 1.000 20.75152 ? 387 SER A CA   1 
ATOM   3012 C C    . SER A 1 207 ? -14.89725 7.89994   -11.84916 1.000 25.24362 ? 387 SER A C    1 
ATOM   3013 O O    . SER A 1 207 ? -14.32951 6.86371   -12.20449 1.000 20.19113 ? 387 SER A O    1 
ATOM   3014 C CB   . SER A 1 207 ? -17.26889 7.60542   -11.13839 1.000 29.55238 ? 387 SER A CB   1 
ATOM   3015 O OG   . SER A 1 207 ? -18.60158 8.05298   -11.31154 1.000 29.41308 ? 387 SER A OG   1 
ATOM   3016 H H    . SER A 1 207 ? -16.59274 6.75189   -13.54779 1.000 34.13379 ? 387 SER A H    1 
ATOM   3017 H HA   . SER A 1 207 ? -16.46555 9.13895   -12.26135 1.000 23.76404 ? 387 SER A HA   1 
ATOM   3018 H HB2  . SER A 1 207 ? -17.25323 6.63697   -11.19093 1.000 35.91491 ? 387 SER A HB2  1 
ATOM   3019 H HB3  . SER A 1 207 ? -16.95023 7.89572   -10.26943 1.000 35.91491 ? 387 SER A HB3  1 
ATOM   3020 H HG   . SER A 1 207 ? -18.89158 7.80869   -12.06109 1.000 35.74774 ? 387 SER A HG   1 
ATOM   3021 N N    . VAL A 1 208 ? -14.30533 8.84475   -11.12467 1.000 18.84184 ? 388 VAL A N    1 
ATOM   3022 C CA   . VAL A 1 208 ? -12.97159 8.69171   -10.56175 1.000 18.38723 ? 388 VAL A CA   1 
ATOM   3023 C C    . VAL A 1 208 ? -12.99400 9.27780   -9.15903  1.000 17.66374 ? 388 VAL A C    1 
ATOM   3024 O O    . VAL A 1 208 ? -13.70048 10.25232  -8.88565  1.000 18.11461 ? 388 VAL A O    1 
ATOM   3025 C CB   . VAL A 1 208 ? -11.89165 9.37302   -11.43074 1.000 37.38338 ? 388 VAL A CB   1 
ATOM   3026 C CG1  . VAL A 1 208 ? -10.59749 9.53483   -10.65446 1.000 25.77948 ? 388 VAL A CG1  1 
ATOM   3027 C CG2  . VAL A 1 208 ? -11.64815 8.56578   -12.69455 1.000 17.79232 ? 388 VAL A CG2  1 
ATOM   3028 H H    . VAL A 1 208 ? -14.66743 9.60301   -10.94158 1.000 20.34997 ? 388 VAL A H    1 
ATOM   3029 H HA   . VAL A 1 208 ? -12.74461 7.75044   -10.50352 1.000 22.51672 ? 388 VAL A HA   1 
ATOM   3030 H HB   . VAL A 1 208 ? -12.20567 10.25605  -11.68083 1.000 45.31211 ? 388 VAL A HB   1 
ATOM   3031 H HG11 . VAL A 1 208 ? -9.90731  9.85741   -11.25487 1.000 31.38742 ? 388 VAL A HG11 1 
ATOM   3032 H HG12 . VAL A 1 208 ? -10.73699 10.17311  -9.93750  1.000 31.38742 ? 388 VAL A HG12 1 
ATOM   3033 H HG13 . VAL A 1 208 ? -10.34036 8.67497   -10.28645 1.000 31.38742 ? 388 VAL A HG13 1 
ATOM   3034 H HG21 . VAL A 1 208 ? -10.96361 9.00520   -13.22296 1.000 19.33134 ? 388 VAL A HG21 1 
ATOM   3035 H HG22 . VAL A 1 208 ? -11.35478 7.67458   -12.44842 1.000 19.33134 ? 388 VAL A HG22 1 
ATOM   3036 H HG23 . VAL A 1 208 ? -12.47421 8.51418   -13.20039 1.000 19.33134 ? 388 VAL A HG23 1 
ATOM   3037 N N    . TRP A 1 209 ? -12.22520 8.66694   -8.26223  1.000 17.54033 ? 389 TRP A N    1 
ATOM   3038 C CA   . TRP A 1 209 ? -12.10628 9.12781   -6.88496  1.000 17.35145 ? 389 TRP A CA   1 
ATOM   3039 C C    . TRP A 1 209 ? -10.64705 9.45485   -6.60701  1.000 16.38188 ? 389 TRP A C    1 
ATOM   3040 O O    . TRP A 1 209 ? -9.78615  8.56964   -6.66551  1.000 17.28313 ? 389 TRP A O    1 
ATOM   3041 C CB   . TRP A 1 209 ? -12.62568 8.07346   -5.90568  1.000 20.58349 ? 389 TRP A CB   1 
ATOM   3042 C CG   . TRP A 1 209 ? -14.11849 7.92505   -5.92910  1.000 20.91198 ? 389 TRP A CG   1 
ATOM   3043 C CD1  . TRP A 1 209 ? -15.03253 8.72901   -5.31199  1.000 19.60997 ? 389 TRP A CD1  1 
ATOM   3044 C CD2  . TRP A 1 209 ? -14.87006 6.90787   -6.60316  1.000 20.34887 ? 389 TRP A CD2  1 
ATOM   3045 N NE1  . TRP A 1 209 ? -16.30603 8.27585   -5.56018  1.000 20.76307 ? 389 TRP A NE1  1 
ATOM   3046 C CE2  . TRP A 1 209 ? -16.23346 7.15927   -6.35090  1.000 21.22228 ? 389 TRP A CE2  1 
ATOM   3047 C CE3  . TRP A 1 209 ? -14.52215 5.80984   -7.39564  1.000 23.84299 ? 389 TRP A CE3  1 
ATOM   3048 C CZ2  . TRP A 1 209 ? -17.24844 6.35234   -6.86208  1.000 22.46424 ? 389 TRP A CZ2  1 
ATOM   3049 C CZ3  . TRP A 1 209 ? -15.53066 5.01102   -7.90273  1.000 23.28478 ? 389 TRP A CZ3  1 
ATOM   3050 C CH2  . TRP A 1 209 ? -16.87721 5.28592   -7.63404  1.000 22.82198 ? 389 TRP A CH2  1 
ATOM   3051 H H    . TRP A 1 209 ? -11.75333 7.96856   -8.43314  1.000 18.78815 ? 389 TRP A H    1 
ATOM   3052 H HA   . TRP A 1 209 ? -12.62877 9.93605   -6.76395  1.000 21.27378 ? 389 TRP A HA   1 
ATOM   3053 H HB2  . TRP A 1 209 ? -12.23738 7.21455   -6.13457  1.000 25.15224 ? 389 TRP A HB2  1 
ATOM   3054 H HB3  . TRP A 1 209 ? -12.36558 8.32596   -5.00596  1.000 25.15224 ? 389 TRP A HB3  1 
ATOM   3055 H HD1  . TRP A 1 209 ? -14.82382 9.47542   -4.79797  1.000 23.65773 ? 389 TRP A HD1  1 
ATOM   3056 H HE1  . TRP A 1 209 ? -17.03049 8.63468   -5.26693  1.000 24.00698 ? 389 TRP A HE1  1 
ATOM   3057 H HE3  . TRP A 1 209 ? -13.63013 5.62041   -7.57815  1.000 29.06364 ? 389 TRP A HE3  1 
ATOM   3058 H HZ2  . TRP A 1 209 ? -18.14359 6.53206   -6.68513  1.000 24.69684 ? 389 TRP A HZ2  1 
ATOM   3059 H HZ3  . TRP A 1 209 ? -15.31074 4.27829   -8.43154  1.000 28.39378 ? 389 TRP A HZ3  1 
ATOM   3060 H HH2  . TRP A 1 209 ? -17.53390 4.73090   -7.98846  1.000 25.12614 ? 389 TRP A HH2  1 
ATOM   3061 N N    . TYR A 1 210 ? -10.37357 10.72243  -6.31067  1.000 15.67887 ? 390 TYR A N    1 
ATOM   3062 C CA   . TYR A 1 210 ? -9.02585  11.17569  -6.00098  1.000 17.82790 ? 390 TYR A CA   1 
ATOM   3063 C C    . TYR A 1 210 ? -8.75298  11.00774  -4.51278  1.000 15.08046 ? 390 TYR A C    1 
ATOM   3064 O O    . TYR A 1 210 ? -9.62115  11.27408  -3.67616  1.000 20.17396 ? 390 TYR A O    1 
ATOM   3065 C CB   . TYR A 1 210 ? -8.84588  12.63436  -6.42434  1.000 15.73053 ? 390 TYR A CB   1 
ATOM   3066 C CG   . TYR A 1 210 ? -8.80790  12.79835  -7.92615  1.000 22.53725 ? 390 TYR A CG   1 
ATOM   3067 C CD1  . TYR A 1 210 ? -7.61111  12.70694  -8.62367  1.000 17.06561 ? 390 TYR A CD1  1 
ATOM   3068 C CD2  . TYR A 1 210 ? -9.97322  13.01075  -8.65129  1.000 18.90592 ? 390 TYR A CD2  1 
ATOM   3069 C CE1  . TYR A 1 210 ? -7.57304  12.83852  -9.99731  1.000 13.77123 ? 390 TYR A CE1  1 
ATOM   3070 C CE2  . TYR A 1 210 ? -9.94405  13.14456  -10.02720 1.000 20.27428 ? 390 TYR A CE2  1 
ATOM   3071 C CZ   . TYR A 1 210 ? -8.73995  13.05507  -10.69365 1.000 14.20309 ? 390 TYR A CZ   1 
ATOM   3072 O OH   . TYR A 1 210 ? -8.69396  13.18553  -12.05903 1.000 19.95545 ? 390 TYR A OH   1 
ATOM   3073 H H    . TYR A 1 210 ? -10.96314 11.34790  -6.28253  1.000 17.26669 ? 390 TYR A H    1 
ATOM   3074 H HA   . TYR A 1 210 ? -8.37504  10.64448  -6.48592  1.000 21.84553 ? 390 TYR A HA   1 
ATOM   3075 H HB2  . TYR A 1 210 ? -9.58769  13.15750  -6.08237  1.000 19.32868 ? 390 TYR A HB2  1 
ATOM   3076 H HB3  . TYR A 1 210 ? -8.00994  12.96843  -6.06311  1.000 19.32868 ? 390 TYR A HB3  1 
ATOM   3077 H HD1  . TYR A 1 210 ? -6.82108  12.55438  -8.15732  1.000 20.93078 ? 390 TYR A HD1  1 
ATOM   3078 H HD2  . TYR A 1 210 ? -10.78681 13.06387  -8.20392  1.000 23.13915 ? 390 TYR A HD2  1 
ATOM   3079 H HE1  . TYR A 1 210 ? -6.76264  12.78108  -10.44992 1.000 14.26524 ? 390 TYR A HE1  1 
ATOM   3080 H HE2  . TYR A 1 210 ? -10.73090 13.29386  -10.49991 1.000 24.78118 ? 390 TYR A HE2  1 
ATOM   3081 H HH   . TYR A 1 210 ? -7.90105  13.11676  -12.32767 1.000 24.39859 ? 390 TYR A HH   1 
ATOM   3082 N N    . PHE A 1 211 ? -7.54544  10.55093  -4.19248  1.000 14.86611 ? 391 PHE A N    1 
ATOM   3083 C CA   . PHE A 1 211 ? -7.17123  10.20601  -2.82882  1.000 17.21164 ? 391 PHE A CA   1 
ATOM   3084 C C    . PHE A 1 211 ? -6.41811  11.34855  -2.16228  1.000 18.55676 ? 391 PHE A C    1 
ATOM   3085 O O    . PHE A 1 211 ? -5.60243  12.02499  -2.79544  1.000 22.80465 ? 391 PHE A O    1 
ATOM   3086 C CB   . PHE A 1 211 ? -6.29168  8.95205   -2.79850  1.000 17.20623 ? 391 PHE A CB   1 
ATOM   3087 C CG   . PHE A 1 211 ? -7.00114  7.69383   -3.20837  1.000 16.42188 ? 391 PHE A CG   1 
ATOM   3088 C CD1  . PHE A 1 211 ? -8.08711  7.22825   -2.48698  1.000 22.04809 ? 391 PHE A CD1  1 
ATOM   3089 C CD2  . PHE A 1 211 ? -6.56693  6.96440   -4.30170  1.000 27.21688 ? 391 PHE A CD2  1 
ATOM   3090 C CE1  . PHE A 1 211 ? -8.73533  6.06733   -2.85697  1.000 18.24417 ? 391 PHE A CE1  1 
ATOM   3091 C CE2  . PHE A 1 211 ? -7.21147  5.80251   -4.67538  1.000 17.46742 ? 391 PHE A CE2  1 
ATOM   3092 C CZ   . PHE A 1 211 ? -8.29511  5.35315   -3.94947  1.000 18.31968 ? 391 PHE A CZ   1 
ATOM   3093 H H    . PHE A 1 211 ? -6.91286  10.43028  -4.76246  1.000 18.21258 ? 391 PHE A H    1 
ATOM   3094 H HA   . PHE A 1 211 ? -7.98349  10.03861  -2.32572  1.000 21.10601 ? 391 PHE A HA   1 
ATOM   3095 H HB2  . PHE A 1 211 ? -5.54644  9.08095   -3.40588  1.000 21.09952 ? 391 PHE A HB2  1 
ATOM   3096 H HB3  . PHE A 1 211 ? -5.96448  8.82427   -1.89434  1.000 21.09952 ? 391 PHE A HB3  1 
ATOM   3097 H HD1  . PHE A 1 211 ? -8.38331  7.70332   -1.74436  1.000 26.90975 ? 391 PHE A HD1  1 
ATOM   3098 H HD2  . PHE A 1 211 ? -5.83281  7.26046   -4.78988  1.000 33.11230 ? 391 PHE A HD2  1 
ATOM   3099 H HE1  . PHE A 1 211 ? -9.46835  5.76765   -2.36934  1.000 20.57732 ? 391 PHE A HE1  1 
ATOM   3100 H HE2  . PHE A 1 211 ? -6.91566  5.32325   -5.41545  1.000 18.70066 ? 391 PHE A HE2  1 
ATOM   3101 H HZ   . PHE A 1 211 ? -8.72820  4.56844   -4.19760  1.000 19.72337 ? 391 PHE A HZ   1 
ATOM   3102 N N    . ASP A 1 212 ? -6.70120  11.55706  -0.87999  1.000 15.06640 ? 392 ASP A N    1 
ATOM   3103 C CA   . ASP A 1 212 ? -5.83058  12.35490  -0.02982  1.000 16.38193 ? 392 ASP A CA   1 
ATOM   3104 C C    . ASP A 1 212 ? -4.69113  11.47154  0.46383   1.000 17.23249 ? 392 ASP A C    1 
ATOM   3105 O O    . ASP A 1 212 ? -4.91904  10.33951  0.90252   1.000 24.65996 ? 392 ASP A O    1 
ATOM   3106 C CB   . ASP A 1 212 ? -6.60918  12.93559  1.14800   1.000 21.24034 ? 392 ASP A CB   1 
ATOM   3107 C CG   . ASP A 1 212 ? -5.75167  13.81605  2.03247   1.000 25.15636 ? 392 ASP A CG   1 
ATOM   3108 O OD1  . ASP A 1 212 ? -5.22700  14.83126  1.52887   1.000 21.41911 ? 392 ASP A OD1  1 
ATOM   3109 O OD2  . ASP A 1 212 ? -5.59897  13.49076  3.22850   1.000 23.97716 ? 392 ASP A OD2  1 
ATOM   3110 H H    . ASP A 1 212 ? -7.39487  11.24527  -0.47848  1.000 16.20615 ? 392 ASP A H    1 
ATOM   3111 H HA   . ASP A 1 212 ? -5.46458  13.10118  -0.52983  1.000 20.11037 ? 392 ASP A HA   1 
ATOM   3112 H HB2  . ASP A 1 212 ? -7.34260  13.47253  0.80935   1.000 25.94046 ? 392 ASP A HB2  1 
ATOM   3113 H HB3  . ASP A 1 212 ? -6.95307  12.20841  1.69008   1.000 25.94046 ? 392 ASP A HB3  1 
ATOM   3114 N N    . ALA A 1 213 ? -3.46383  11.98758  0.38954   1.000 23.09829 ? 393 ALA A N    1 
ATOM   3115 C CA   . ALA A 1 213 ? -2.29448  11.15400  0.65282   1.000 25.19777 ? 393 ALA A CA   1 
ATOM   3116 C C    . ALA A 1 213 ? -2.33067  10.56815  2.06039   1.000 29.47572 ? 393 ALA A C    1 
ATOM   3117 O O    . ALA A 1 213 ? -2.19905  9.35245   2.24251   1.000 28.00453 ? 393 ALA A O    1 
ATOM   3118 C CB   . ALA A 1 213 ? -1.01825  11.96909  0.43985   1.000 23.68489 ? 393 ALA A CB   1 
ATOM   3119 H H    . ALA A 1 213 ? -3.28436  12.80503  0.19164   1.000 28.17000 ? 393 ALA A H    1 
ATOM   3120 H HA   . ALA A 1 213 ? -2.29338  10.41432  0.02530   1.000 30.68937 ? 393 ALA A HA   1 
ATOM   3121 H HB1  . ALA A 1 213 ? -0.24967  11.40432  0.61653   1.000 28.87391 ? 393 ALA A HB1  1 
ATOM   3122 H HB2  . ALA A 1 213 ? -0.99376  12.28357  -0.47743  1.000 28.87391 ? 393 ALA A HB2  1 
ATOM   3123 H HB3  . ALA A 1 213 ? -1.02064  12.72435  1.04851   1.000 28.87391 ? 393 ALA A HB3  1 
ATOM   3124 N N    . ASP A 1 214 ? -2.51540  11.41796  3.07143   1.000 32.08313 ? 394 ASP A N    1 
ATOM   3125 C CA   . ASP A 1 214 ? -2.44383  10.95127  4.45323   1.000 29.37734 ? 394 ASP A CA   1 
ATOM   3126 C C    . ASP A 1 214 ? -3.60044  10.01420  4.78609   1.000 38.51497 ? 394 ASP A C    1 
ATOM   3127 O O    . ASP A 1 214 ? -3.40055  8.94654   5.38325   1.000 29.01230 ? 394 ASP A O    1 
ATOM   3128 C CB   . ASP A 1 214 ? -2.43413  12.14898  5.40223   1.000 21.38123 ? 394 ASP A CB   1 
ATOM   3129 C CG   . ASP A 1 214 ? -1.23688  13.05118  5.18796   1.000 37.11442 ? 394 ASP A CG   1 
ATOM   3130 O OD1  . ASP A 1 214 ? -0.14371  12.52875  4.88440   1.000 37.68287 ? 394 ASP A OD1  1 
ATOM   3131 O OD2  . ASP A 1 214 ? -1.38925  14.28329  5.32257   1.000 37.96661 ? 394 ASP A OD2  1 
ATOM   3132 H H    . ASP A 1 214 ? -2.68115  12.25740  2.98495   1.000 38.95181 ? 394 ASP A H    1 
ATOM   3133 H HA   . ASP A 1 214 ? -1.61773  10.45710  4.57266   1.000 35.70486 ? 394 ASP A HA   1 
ATOM   3134 H HB2  . ASP A 1 214 ? -3.23641  12.67454  5.25718   1.000 26.10953 ? 394 ASP A HB2  1 
ATOM   3135 H HB3  . ASP A 1 214 ? -2.40875  11.82794  6.31720   1.000 26.10953 ? 394 ASP A HB3  1 
ATOM   3136 N N    . GLU A 1 215 ? -4.82394  10.40525  4.42189   1.000 28.91689 ? 395 GLU A N    1 
ATOM   3137 C CA   . GLU A 1 215 ? -5.98004  9.56797   4.72081   1.000 34.28644 ? 395 GLU A CA   1 
ATOM   3138 C C    . GLU A 1 215 ? -5.89607  8.23718   3.98644   1.000 24.57925 ? 395 GLU A C    1 
ATOM   3139 O O    . GLU A 1 215 ? -6.22472  7.18658   4.54923   1.000 30.79929 ? 395 GLU A O    1 
ATOM   3140 C CB   . GLU A 1 215 ? -7.26986  10.29969  4.35380   1.000 20.21432 ? 395 GLU A CB   1 
ATOM   3141 C CG   . GLU A 1 215 ? -8.52689  9.61341   4.86538   1.000 25.76099 ? 395 GLU A CG   1 
ATOM   3142 C CD   . GLU A 1 215 ? -9.79604  10.26826  4.36334   1.000 29.41851 ? 395 GLU A CD   1 
ATOM   3143 O OE1  . GLU A 1 215 ? -10.04431 11.43908  4.71967   1.000 38.45433 ? 395 GLU A OE1  1 
ATOM   3144 O OE2  . GLU A 1 215 ? -10.54683 9.60890   3.61327   1.000 22.73440 ? 395 GLU A OE2  1 
ATOM   3145 H H    . GLU A 1 215 ? -5.00607  11.13716  4.00868   1.000 35.15232 ? 395 GLU A H    1 
ATOM   3146 H HA   . GLU A 1 215 ? -5.99809  9.38893   5.67397   1.000 41.59578 ? 395 GLU A HA   1 
ATOM   3147 H HB2  . GLU A 1 215 ? -7.24247  11.19117  4.73513   1.000 24.70923 ? 395 GLU A HB2  1 
ATOM   3148 H HB3  . GLU A 1 215 ? -7.33391  10.35404  3.38745   1.000 24.70923 ? 395 GLU A HB3  1 
ATOM   3149 H HG2  . GLU A 1 215 ? -8.52708  8.69047   4.56691   1.000 31.36523 ? 395 GLU A HG2  1 
ATOM   3150 H HG3  . GLU A 1 215 ? -8.53421  9.64861   5.83472   1.000 31.36523 ? 395 GLU A HG3  1 
ATOM   3151 N N    . ARG A 1 216 ? -5.46852  8.26274   2.72255   1.000 18.29586 ? 396 ARG A N    1 
ATOM   3152 C CA   . ARG A 1 216 ? -5.32289  7.02102   1.97075   1.000 27.67686 ? 396 ARG A CA   1 
ATOM   3153 C C    . ARG A 1 216 ? -4.24530  6.13638   2.58305   1.000 29.32410 ? 396 ARG A C    1 
ATOM   3154 O O    . ARG A 1 216 ? -4.39254  4.90954   2.63269   1.000 22.16938 ? 396 ARG A O    1 
ATOM   3155 C CB   . ARG A 1 216 ? -5.00485  7.32818   0.50708   1.000 26.27877 ? 396 ARG A CB   1 
ATOM   3156 C CG   . ARG A 1 216 ? -4.96772  6.10600   -0.40979  1.000 21.39809 ? 396 ARG A CG   1 
ATOM   3157 C CD   . ARG A 1 216 ? -6.18578  5.20743   -0.22523  1.000 18.82222 ? 396 ARG A CD   1 
ATOM   3158 N NE   . ARG A 1 216 ? -6.23970  4.14178   -1.21904  1.000 25.30986 ? 396 ARG A NE   1 
ATOM   3159 C CZ   . ARG A 1 216 ? -7.21778  3.25088   -1.31175  1.000 26.75552 ? 396 ARG A CZ   1 
ATOM   3160 N NH1  . ARG A 1 216 ? -8.24286  3.25891   -0.47515  1.000 21.04738 ? 396 ARG A NH1  1 
ATOM   3161 N NH2  . ARG A 1 216 ? -7.16704  2.32936   -2.26927  1.000 23.18086 ? 396 ARG A NH2  1 
ATOM   3162 H H    . ARG A 1 216 ? -5.26019  8.97398   2.28629   1.000 22.40708 ? 396 ARG A H    1 
ATOM   3163 H HA   . ARG A 1 216 ? -6.16203  6.53514   1.99661   1.000 33.66428 ? 396 ARG A HA   1 
ATOM   3164 H HB2  . ARG A 1 216 ? -5.68401  7.92985   0.16410   1.000 31.98657 ? 396 ARG A HB2  1 
ATOM   3165 H HB3  . ARG A 1 216 ? -4.13351  7.75219   0.46372   1.000 31.98657 ? 396 ARG A HB3  1 
ATOM   3166 H HG2  . ARG A 1 216 ? -4.94820  6.40150   -1.33348  1.000 26.12976 ? 396 ARG A HG2  1 
ATOM   3167 H HG3  . ARG A 1 216 ? -4.17480  5.58352   -0.21179  1.000 26.12976 ? 396 ARG A HG3  1 
ATOM   3168 H HD2  . ARG A 1 216 ? -6.15003  4.79915   0.65394   1.000 21.51889 ? 396 ARG A HD2  1 
ATOM   3169 H HD3  . ARG A 1 216 ? -6.99117  5.74124   -0.31061  1.000 21.51889 ? 396 ARG A HD3  1 
ATOM   3170 H HE   . ARG A 1 216 ? -5.59320  4.08726   -1.78354  1.000 30.82388 ? 396 ARG A HE   1 
ATOM   3171 H HH11 . ARG A 1 216 ? -8.28566  3.85130   0.14681   1.000 24.96130 ? 396 ARG A HH11 1 
ATOM   3172 H HH12 . ARG A 1 216 ? -8.86633  2.67174   -0.55337  1.000 24.96130 ? 396 ARG A HH12 1 
ATOM   3173 H HH21 . ARG A 1 216 ? -6.50563  2.31619   -2.81877  1.000 28.26908 ? 396 ARG A HH21 1 
ATOM   3174 H HH22 . ARG A 1 216 ? -7.79565  1.74662   -2.33896  1.000 28.26908 ? 396 ARG A HH22 1 
ATOM   3175 N N    . ALA A 1 217 ? -3.15160  6.73960   3.05309   1.000 25.23131 ? 397 ALA A N    1 
ATOM   3176 C CA   . ALA A 1 217 ? -2.11389  5.96475   3.72321   1.000 30.30153 ? 397 ALA A CA   1 
ATOM   3177 C C    . ALA A 1 217 ? -2.66579  5.28253   4.96865   1.000 30.98796 ? 397 ALA A C    1 
ATOM   3178 O O    . ALA A 1 217 ? -2.41324  4.09537   5.20548   1.000 28.52536 ? 397 ALA A O    1 
ATOM   3179 C CB   . ALA A 1 217 ? -0.93534  6.87154   4.07962   1.000 24.90423 ? 397 ALA A CB   1 
ATOM   3180 H H    . ALA A 1 217 ? -2.99076  7.58255   2.99674   1.000 30.72963 ? 397 ALA A H    1 
ATOM   3181 H HA   . ALA A 1 217 ? -1.79204  5.27726   3.11934   1.000 36.81388 ? 397 ALA A HA   1 
ATOM   3182 H HB1  . ALA A 1 217 ? -0.25392  6.34361   4.52444   1.000 30.33713 ? 397 ALA A HB1  1 
ATOM   3183 H HB2  . ALA A 1 217 ? -0.57595  7.25706   3.26530   1.000 30.33713 ? 397 ALA A HB2  1 
ATOM   3184 H HB3  . ALA A 1 217 ? -1.24595  7.57577   4.66995   1.000 30.33713 ? 397 ALA A HB3  1 
ATOM   3185 N N    . ARG A 1 218 ? -3.43172  6.01953   5.77723   1.000 33.10452 ? 398 ARG A N    1 
ATOM   3186 C CA   . ARG A 1 218 ? -4.01221  5.42056   6.97778   1.000 22.22996 ? 398 ARG A CA   1 
ATOM   3187 C C    . ARG A 1 218 ? -4.99287  4.30711   6.62247   1.000 25.90740 ? 398 ARG A C    1 
ATOM   3188 O O    . ARG A 1 218 ? -5.02764  3.26220   7.28507   1.000 24.52004 ? 398 ARG A O    1 
ATOM   3189 C CB   . ARG A 1 218 ? -4.70237  6.48984   7.82334   1.000 26.38571 ? 398 ARG A CB   1 
ATOM   3190 C CG   . ARG A 1 218 ? -3.74716  7.47499   8.47646   1.000 21.95027 ? 398 ARG A CG   1 
ATOM   3191 C CD   . ARG A 1 218 ? -4.47069  8.37263   9.46895   1.000 29.34139 ? 398 ARG A CD   1 
ATOM   3192 N NE   . ARG A 1 218 ? -5.54140  9.13694   8.83837   1.000 31.25002 ? 398 ARG A NE   1 
ATOM   3193 C CZ   . ARG A 1 218 ? -5.41379  10.37081  8.36699   1.000 31.21622 ? 398 ARG A CZ   1 
ATOM   3194 N NH1  . ARG A 1 218 ? -4.26550  11.02522  8.43685   1.000 36.59371 ? 398 ARG A NH1  1 
ATOM   3195 N NH2  . ARG A 1 218 ? -6.46537  10.96275  7.80767   1.000 33.49717 ? 398 ARG A NH2  1 
ATOM   3196 H H    . ARG A 1 218 ? -3.62563  6.84853   5.65575   1.000 40.17748 ? 398 ARG A H    1 
ATOM   3197 H HA   . ARG A 1 218 ? -3.29654  5.03571   7.50751   1.000 24.41571 ? 398 ARG A HA   1 
ATOM   3198 H HB2  . ARG A 1 218 ? -5.30389  6.99531   7.25450   1.000 32.11490 ? 398 ARG A HB2  1 
ATOM   3199 H HB3  . ARG A 1 218 ? -5.20299  6.05217   8.52954   1.000 32.11490 ? 398 ARG A HB3  1 
ATOM   3200 H HG2  . ARG A 1 218 ? -3.05720  6.98695   8.95256   1.000 24.08008 ? 398 ARG A HG2  1 
ATOM   3201 H HG3  . ARG A 1 218 ? -3.34611  8.03533   7.79375   1.000 24.08008 ? 398 ARG A HG3  1 
ATOM   3202 H HD2  . ARG A 1 218 ? -4.86104  7.82521   10.16814  1.000 35.66171 ? 398 ARG A HD2  1 
ATOM   3203 H HD3  . ARG A 1 218 ? -3.83733  8.99908   9.85275   1.000 35.66171 ? 398 ARG A HD3  1 
ATOM   3204 H HE   . ARG A 1 218 ? -6.31132  8.76048   8.76694   1.000 37.95208 ? 398 ARG A HE   1 
ATOM   3205 H HH11 . ARG A 1 218 ? -3.57855  10.65131  8.79448   1.000 44.36450 ? 398 ARG A HH11 1 
ATOM   3206 H HH12 . ARG A 1 218 ? -4.20630  11.82434  8.12461   1.000 44.36450 ? 398 ARG A HH12 1 
ATOM   3207 H HH21 . ARG A 1 218 ? -7.21583  10.54605  7.75508   1.000 40.64865 ? 398 ARG A HH21 1 
ATOM   3208 H HH22 . ARG A 1 218 ? -6.39484  11.76219  7.49861   1.000 40.64865 ? 398 ARG A HH22 1 
ATOM   3209 N N    . ALA A 1 219 ? -5.80644  4.51591   5.58482   1.000 28.67822 ? 399 ALA A N    1 
ATOM   3210 C CA   . ALA A 1 219 ? -6.75217  3.48463   5.16956   1.000 30.56451 ? 399 ALA A CA   1 
ATOM   3211 C C    . ALA A 1 219 ? -6.02722  2.22587   4.70963   1.000 28.25461 ? 399 ALA A C    1 
ATOM   3212 O O    . ALA A 1 219 ? -6.43717  1.10523   5.03906   1.000 25.34074 ? 399 ALA A O    1 
ATOM   3213 C CB   . ALA A 1 219 ? -7.65295  4.01857   4.05668   1.000 31.29524 ? 399 ALA A CB   1 
ATOM   3214 H H    . ALA A 1 219 ? -5.82929  5.23464   5.11311   1.000 34.86592 ? 399 ALA A H    1 
ATOM   3215 H HA   . ALA A 1 219 ? -7.31258  3.25104   5.92605   1.000 37.12946 ? 399 ALA A HA   1 
ATOM   3216 H HB1  . ALA A 1 219 ? -8.27494  3.32266   3.79261   1.000 38.00633 ? 399 ALA A HB1  1 
ATOM   3217 H HB2  . ALA A 1 219 ? -8.14003  4.78954   4.38722   1.000 38.00633 ? 399 ALA A HB2  1 
ATOM   3218 H HB3  . ALA A 1 219 ? -7.10236  4.27456   3.30023   1.000 38.00633 ? 399 ALA A HB3  1 
ATOM   3219 N N    . LYS A 1 220 ? -4.95049  2.38971   3.93832   1.000 23.12252 ? 400 LYS A N    1 
ATOM   3220 C CA   . LYS A 1 220 ? -4.17406  1.23439   3.50263   1.000 25.51004 ? 400 LYS A CA   1 
ATOM   3221 C C    . LYS A 1 220 ? -3.52474  0.53469   4.68873   1.000 25.08905 ? 400 LYS A C    1 
ATOM   3222 O O    . LYS A 1 220 ? -3.44207  -0.69807  4.72189   1.000 29.11938 ? 400 LYS A O    1 
ATOM   3223 C CB   . LYS A 1 220 ? -3.11840  1.66289   2.48445   1.000 34.93006 ? 400 LYS A CB   1 
ATOM   3224 C CG   . LYS A 1 220 ? -3.64001  1.73693   1.05833   1.000 21.72160 ? 400 LYS A CG   1 
ATOM   3225 C CD   . LYS A 1 220 ? -2.54940  2.15276   0.08658   1.000 24.56254 ? 400 LYS A CD   1 
ATOM   3226 C CE   . LYS A 1 220 ? -3.06943  2.19688   -1.33945  1.000 27.06963 ? 400 LYS A CE   1 
ATOM   3227 N NZ   . LYS A 1 220 ? -3.33627  0.83736   -1.88315  1.000 39.20926 ? 400 LYS A NZ   1 
ATOM   3228 H H    . LYS A 1 220 ? -4.65462  3.14734   3.65893   1.000 28.19907 ? 400 LYS A H    1 
ATOM   3229 H HA   . LYS A 1 220 ? -4.76733  0.60267   3.06691   1.000 31.06410 ? 400 LYS A HA   1 
ATOM   3230 H HB2  . LYS A 1 220 ? -2.79073  2.54324   2.72634   1.000 42.36812 ? 400 LYS A HB2  1 
ATOM   3231 H HB3  . LYS A 1 220 ? -2.39056  1.02189   2.50100   1.000 42.36812 ? 400 LYS A HB3  1 
ATOM   3232 H HG2  . LYS A 1 220 ? -3.96968  0.86464   0.79125   1.000 23.80567 ? 400 LYS A HG2  1 
ATOM   3233 H HG3  . LYS A 1 220 ? -4.35524  2.39050   1.01149   1.000 23.80567 ? 400 LYS A HG3  1 
ATOM   3234 H HD2  . LYS A 1 220 ? -2.22790  3.03705   0.32232   1.000 29.92709 ? 400 LYS A HD2  1 
ATOM   3235 H HD3  . LYS A 1 220 ? -1.82111  1.51333   0.12684   1.000 29.92709 ? 400 LYS A HD3  1 
ATOM   3236 H HE2  . LYS A 1 220 ? -3.89920  2.69880   -1.36042  1.000 32.93561 ? 400 LYS A HE2  1 
ATOM   3237 H HE3  . LYS A 1 220 ? -2.40859  2.62454   -1.90629  1.000 32.93561 ? 400 LYS A HE3  1 
ATOM   3238 H HZ1  . LYS A 1 220 ? -2.58812  0.35534   -1.87831  1.000 47.50316 ? 400 LYS A HZ1  1 
ATOM   3239 H HZ2  . LYS A 1 220 ? -3.94854  0.42535   -1.38568  1.000 47.50316 ? 400 LYS A HZ2  1 
ATOM   3240 H HZ3  . LYS A 1 220 ? -3.63588  0.89723   -2.71906  1.000 47.50316 ? 400 LYS A HZ3  1 
ATOM   3241 N N    . VAL A 1 221 ? -3.05159  1.30407   5.67101   1.000 31.32679 ? 401 VAL A N    1 
ATOM   3242 C CA   . VAL A 1 221 ? -2.49177  0.70109   6.87825   1.000 32.08192 ? 401 VAL A CA   1 
ATOM   3243 C C    . VAL A 1 221 ? -3.54614  -0.14844  7.57497   1.000 27.65303 ? 401 VAL A C    1 
ATOM   3244 O O    . VAL A 1 221 ? -3.28086  -1.27911  8.00049   1.000 37.19608 ? 401 VAL A O    1 
ATOM   3245 C CB   . VAL A 1 221 ? -1.94079  1.78971   7.81729   1.000 39.05335 ? 401 VAL A CB   1 
ATOM   3246 C CG1  . VAL A 1 221 ? -1.74713  1.23366   9.22433   1.000 27.24296 ? 401 VAL A CG1  1 
ATOM   3247 C CG2  . VAL A 1 221 ? -0.63690  2.35120   7.27531   1.000 37.19443 ? 401 VAL A CG2  1 
ATOM   3248 H H    . VAL A 1 221 ? -3.04354  2.16399   5.66253   1.000 38.04420 ? 401 VAL A H    1 
ATOM   3249 H HA   . VAL A 1 221 ? -1.75528  0.12371   6.62308   1.000 38.95035 ? 401 VAL A HA   1 
ATOM   3250 H HB   . VAL A 1 221 ? -2.58226  2.51563   7.86683   1.000 47.31606 ? 401 VAL A HB   1 
ATOM   3251 H HG11 . VAL A 1 221 ? -1.15379  1.82166   9.71738   1.000 31.98035 ? 401 VAL A HG11 1 
ATOM   3252 H HG12 . VAL A 1 221 ? -2.60908  1.18678   9.66677   1.000 31.98035 ? 401 VAL A HG12 1 
ATOM   3253 H HG13 . VAL A 1 221 ? -1.35825  0.34716   9.16281   1.000 31.98035 ? 401 VAL A HG13 1 
ATOM   3254 H HG21 . VAL A 1 221 ? -0.35925  3.09676   7.83025   1.000 45.08537 ? 401 VAL A HG21 1 
ATOM   3255 H HG22 . VAL A 1 221 ? 0.03861   1.65533   7.29407   1.000 45.08537 ? 401 VAL A HG22 1 
ATOM   3256 H HG23 . VAL A 1 221 ? -0.77712  2.65159   6.36372   1.000 45.08537 ? 401 VAL A HG23 1 
ATOM   3257 N N    . LYS A 1 222 ? -4.76125  0.38801   7.70329   1.000 29.41850 ? 402 LYS A N    1 
ATOM   3258 C CA   . LYS A 1 222 ? -5.83046  -0.36296  8.35400   1.000 31.43802 ? 402 LYS A CA   1 
ATOM   3259 C C    . LYS A 1 222 ? -6.15568  -1.63686  7.58478   1.000 30.08118 ? 402 LYS A C    1 
ATOM   3260 O O    . LYS A 1 222 ? -6.33735  -2.70390  8.18300   1.000 34.25721 ? 402 LYS A O    1 
ATOM   3261 C CB   . LYS A 1 222 ? -7.07967  0.50714   8.49001   1.000 36.92243 ? 402 LYS A CB   1 
ATOM   3262 C CG   . LYS A 1 222 ? -7.20213  1.20865   9.83204   1.000 42.03618 ? 402 LYS A CG   1 
ATOM   3263 C CD   . LYS A 1 222 ? -8.22228  2.33423   9.77905   1.000 41.03198 ? 402 LYS A CD   1 
ATOM   3264 H H    . LYS A 1 222 ? -4.98728  1.17042   7.42698   1.000 35.75425 ? 402 LYS A H    1 
ATOM   3265 H HA   . LYS A 1 222 ? -5.53689  -0.61116  9.24457   1.000 38.17768 ? 402 LYS A HA   1 
ATOM   3266 H HB2  . LYS A 1 222 ? -7.05936  1.18976   7.80115   1.000 44.75896 ? 402 LYS A HB2  1 
ATOM   3267 H HB3  . LYS A 1 222 ? -7.86289  -0.05403  8.37798   1.000 44.75896 ? 402 LYS A HB3  1 
ATOM   3268 H HG2  . LYS A 1 222 ? -7.48717  0.56983   10.50402  1.000 50.89546 ? 402 LYS A HG2  1 
ATOM   3269 H HG3  . LYS A 1 222 ? -6.34304  1.58667   10.07691  1.000 50.89546 ? 402 LYS A HG3  1 
ATOM   3270 N N    . TYR A 1 223 ? -6.23794  -1.54407  6.25600   1.000 35.01717 ? 403 TYR A N    1 
ATOM   3271 C CA   . TYR A 1 223 ? -6.57022  -2.71871  5.45614   1.000 29.87869 ? 403 TYR A CA   1 
ATOM   3272 C C    . TYR A 1 223 ? -5.48444  -3.78449  5.55296   1.000 37.02173 ? 403 TYR A C    1 
ATOM   3273 O O    . TYR A 1 223 ? -5.78391  -4.97344  5.71257   1.000 35.67703 ? 403 TYR A O    1 
ATOM   3274 C CB   . TYR A 1 223 ? -6.78492  -2.31660  3.99859   1.000 35.58359 ? 403 TYR A CB   1 
ATOM   3275 C CG   . TYR A 1 223 ? -6.84222  -3.49391  3.05548   1.000 36.41493 ? 403 TYR A CG   1 
ATOM   3276 C CD1  . TYR A 1 223 ? -8.03018  -4.17911  2.83647   1.000 40.27147 ? 403 TYR A CD1  1 
ATOM   3277 C CD2  . TYR A 1 223 ? -5.70221  -3.93598  2.40208   1.000 41.04410 ? 403 TYR A CD2  1 
ATOM   3278 C CE1  . TYR A 1 223 ? -8.08194  -5.26032  1.97731   1.000 44.69228 ? 403 TYR A CE1  1 
ATOM   3279 C CE2  . TYR A 1 223 ? -5.74347  -5.01572  1.55122   1.000 43.62911 ? 403 TYR A CE2  1 
ATOM   3280 C CZ   . TYR A 1 223 ? -6.93419  -5.67412  1.33748   1.000 46.29408 ? 403 TYR A CZ   1 
ATOM   3281 O OH   . TYR A 1 223 ? -6.97252  -6.75141  0.48217   1.000 59.84108 ? 403 TYR A OH   1 
ATOM   3282 H H    . TYR A 1 223 ? -6.10805  -0.82501  5.80248   1.000 42.47265 ? 403 TYR A H    1 
ATOM   3283 H HA   . TYR A 1 223 ? -7.39672  -3.09754  5.79420   1.000 36.02385 ? 403 TYR A HA   1 
ATOM   3284 H HB2  . TYR A 1 223 ? -7.62442  -1.83603  3.92642   1.000 43.15236 ? 403 TYR A HB2  1 
ATOM   3285 H HB3  . TYR A 1 223 ? -6.05134  -1.74671  3.71934   1.000 43.15236 ? 403 TYR A HB3  1 
ATOM   3286 H HD1  . TYR A 1 223 ? -8.80341  -3.90592  3.27509   1.000 48.77781 ? 403 TYR A HD1  1 
ATOM   3287 H HD2  . TYR A 1 223 ? -4.89553  -3.49471  2.54154   1.000 49.70496 ? 403 TYR A HD2  1 
ATOM   3288 H HE1  . TYR A 1 223 ? -8.88559  -5.70527  1.83214   1.000 54.08279 ? 403 TYR A HE1  1 
ATOM   3289 H HE2  . TYR A 1 223 ? -4.96950  -5.30050  1.12138   1.000 52.80697 ? 403 TYR A HE2  1 
ATOM   3290 H HH   . TYR A 1 223 ? -6.21673  -6.86983  0.13523   1.000 72.26134 ? 403 TYR A HH   1 
ATOM   3291 N N    . LEU A 1 224 ? -4.21642  -3.37753  5.45500   1.000 41.18961 ? 404 LEU A N    1 
ATOM   3292 C CA   . LEU A 1 224 ? -3.11311  -4.33047  5.43506   1.000 34.32272 ? 404 LEU A CA   1 
ATOM   3293 C C    . LEU A 1 224 ? -2.88336  -4.98886  6.78884   1.000 35.10781 ? 404 LEU A C    1 
ATOM   3294 O O    . LEU A 1 224 ? -2.23319  -6.03807  6.84950   1.000 51.14865 ? 404 LEU A O    1 
ATOM   3295 C CB   . LEU A 1 224 ? -1.83374  -3.62812  4.97466   1.000 38.79336 ? 404 LEU A CB   1 
ATOM   3296 C CG   . LEU A 1 224 ? -1.85881  -3.07659  3.54584   1.000 37.29394 ? 404 LEU A CG   1 
ATOM   3297 C CD1  . LEU A 1 224 ? -0.68990  -2.13397  3.30905   1.000 35.02215 ? 404 LEU A CD1  1 
ATOM   3298 C CD2  . LEU A 1 224 ? -1.84089  -4.20782  2.52986   1.000 34.35459 ? 404 LEU A CD2  1 
ATOM   3299 H H    . LEU A 1 224 ? -3.97124  -2.55514  5.39890   1.000 49.87958 ? 404 LEU A H    1 
ATOM   3300 H HA   . LEU A 1 224 ? -3.32129  -5.03358  4.80009   1.000 41.63931 ? 404 LEU A HA   1 
ATOM   3301 H HB2  . LEU A 1 224 ? -1.66624  -2.88077  5.56991   1.000 47.00408 ? 404 LEU A HB2  1 
ATOM   3302 H HB3  . LEU A 1 224 ? -1.10273  -4.26362  5.02624   1.000 47.00408 ? 404 LEU A HB3  1 
ATOM   3303 H HG   . LEU A 1 224 ? -2.67975  -2.57451  3.42394   1.000 45.20478 ? 404 LEU A HG   1 
ATOM   3304 H HD11 . LEU A 1 224 ? -0.73111  -1.80231  2.39845   1.000 42.47863 ? 404 LEU A HD11 1 
ATOM   3305 H HD12 . LEU A 1 224 ? -0.74931  -1.39413  3.93356   1.000 42.47863 ? 404 LEU A HD12 1 
ATOM   3306 H HD13 . LEU A 1 224 ? 0.13921   -2.61801  3.44758   1.000 42.47863 ? 404 LEU A HD13 1 
ATOM   3307 H HD21 . LEU A 1 224 ? -1.79195  -3.83027  1.63770   1.000 41.67756 ? 404 LEU A HD21 1 
ATOM   3308 H HD22 . LEU A 1 224 ? -1.06652  -4.76821  2.69483   1.000 41.67756 ? 404 LEU A HD22 1 
ATOM   3309 H HD23 . LEU A 1 224 ? -2.65303  -4.72978  2.62406   1.000 41.67756 ? 404 LEU A HD23 1 
ATOM   3310 N N    . THR A 1 225 ? -3.39518  -4.40290  7.86935   1.000 34.78551 ? 405 THR A N    1 
ATOM   3311 C CA   . THR A 1 225 ? -3.23372  -4.94914  9.20917   1.000 35.86886 ? 405 THR A CA   1 
ATOM   3312 C C    . THR A 1 225 ? -4.44786  -5.74802  9.66592   1.000 39.77831 ? 405 THR A C    1 
ATOM   3313 O O    . THR A 1 225 ? -4.50548  -6.15706  10.82997  1.000 40.74614 ? 405 THR A O    1 
ATOM   3314 C CB   . THR A 1 225 ? -2.95476  -3.82405  10.20891  1.000 34.11634 ? 405 THR A CB   1 
ATOM   3315 O OG1  . THR A 1 225 ? -4.02707  -2.87382  10.17677  1.000 39.90729 ? 405 THR A OG1  1 
ATOM   3316 C CG2  . THR A 1 225 ? -1.64445  -3.12277  9.87740   1.000 37.90634 ? 405 THR A CG2  1 
ATOM   3317 H H    . THR A 1 225 ? -3.84908  -3.67273  7.84846   1.000 42.19467 ? 405 THR A H    1 
ATOM   3318 H HA   . THR A 1 225 ? -2.46764  -5.54412  9.20386   1.000 43.49468 ? 405 THR A HA   1 
ATOM   3319 H HB   . THR A 1 225 ? -2.88180  -4.19698  11.10137  1.000 38.67936 ? 405 THR A HB   1 
ATOM   3320 H HG1  . THR A 1 225 ? -4.07739  -2.52307  9.41516   1.000 48.34079 ? 405 THR A HG1  1 
ATOM   3321 H HG21 . THR A 1 225 ? -1.52169  -2.35663  10.45952  1.000 45.93966 ? 405 THR A HG21 1 
ATOM   3322 H HG22 . THR A 1 225 ? -0.90098  -3.73361  9.99999   1.000 45.93966 ? 405 THR A HG22 1 
ATOM   3323 H HG23 . THR A 1 225 ? -1.65423  -2.81970  8.95602   1.000 45.93966 ? 405 THR A HG23 1 
ATOM   3324 N N    . GLY A 1 226 ? -5.41529  -5.97530  8.78360   1.000 39.95974 ? 406 GLY A N    1 
ATOM   3325 C CA   . GLY A 1 226 ? -6.62297  -6.69304  9.14524   1.000 60.53266 ? 406 GLY A CA   1 
ATOM   3326 C C    . GLY A 1 226 ? -7.66989  -5.78859  9.76554   1.000 65.78379 ? 406 GLY A C    1 
ATOM   3327 O O    . GLY A 1 226 ? -8.38438  -6.18802  10.68482  1.000 88.45997 ? 406 GLY A O    1 
ATOM   3328 H H    . GLY A 1 226 ? -5.39237  -5.72017  7.96264   1.000 48.40374 ? 406 GLY A H    1 
ATOM   3329 H HA2  . GLY A 1 226 ? -7.00312  -7.10127  8.35168   1.000 73.09124 ? 406 GLY A HA2  1 
ATOM   3330 H HA3  . GLY A 1 226 ? -6.40313  -7.38912  9.78402   1.000 73.09124 ? 406 GLY A HA3  1 
ATOM   3331 N N    . LEU B 2 1   ? -27.47857 2.11892   8.66177   1.000 50.29485 ? 524 LEU B N    1 
ATOM   3332 C CA   . LEU B 2 1   ? -26.61379 2.25404   9.82784   1.000 47.86654 ? 524 LEU B CA   1 
ATOM   3333 C C    . LEU B 2 1   ? -25.15640 2.37762   9.39573   1.000 46.13616 ? 524 LEU B C    1 
ATOM   3334 O O    . LEU B 2 1   ? -24.64475 3.48407   9.22204   1.000 46.58888 ? 524 LEU B O    1 
ATOM   3335 C CB   . LEU B 2 1   ? -26.79099 1.06134   10.76900  1.000 33.92259 ? 524 LEU B CB   1 
ATOM   3336 H H1   A LEU B 2 1   ? -27.05856 2.13777   7.91128   0.440 60.80587 ? 524 LEU B H1   1 
ATOM   3337 H H1   B LEU B 2 1   ? -27.05854 2.13782   7.91129   0.560 60.80587 ? 524 LEU B H1   1 
ATOM   3338 H HA   . LEU B 2 1   ? -26.85553 3.05443   10.31961  1.000 57.89190 ? 524 LEU B HA   1 
ATOM   3339 N N    . ASP B 2 2   ? -24.49040 1.23781   9.22264   1.000 39.69084 ? 525 ASP B N    1 
ATOM   3340 C CA   . ASP B 2 2   ? -23.11018 1.22792   8.74919   1.000 29.80094 ? 525 ASP B CA   1 
ATOM   3341 C C    . ASP B 2 2   ? -23.08523 1.74360   7.31634   1.000 37.98229 ? 525 ASP B C    1 
ATOM   3342 O O    . ASP B 2 2   ? -23.50315 1.04355   6.38826   1.000 35.30167 ? 525 ASP B O    1 
ATOM   3343 C CB   . ASP B 2 2   ? -22.53076 -0.18056  8.84186   1.000 30.03751 ? 525 ASP B CB   1 
ATOM   3344 C CG   . ASP B 2 2   ? -21.04863 -0.22967  8.51121   1.000 38.99370 ? 525 ASP B CG   1 
ATOM   3345 O OD1  . ASP B 2 2   ? -20.55531 0.67787   7.80899   1.000 47.26515 ? 525 ASP B OD1  1 
ATOM   3346 O OD2  . ASP B 2 2   ? -20.37395 -1.18192  8.95584   1.000 41.33042 ? 525 ASP B OD2  1 
ATOM   3347 H H    . ASP B 2 2   ? -24.81679 0.45645   9.37282   1.000 48.08106 ? 525 ASP B H    1 
ATOM   3348 H HA   . ASP B 2 2   ? -22.56543 1.80879   9.30303   1.000 33.50088 ? 525 ASP B HA   1 
ATOM   3349 H HB2  . ASP B 2 2   ? -22.64738 -0.51141  9.74620   1.000 34.90779 ? 525 ASP B HB2  1 
ATOM   3350 H HB3  . ASP B 2 2   ? -22.99699 -0.75594  8.21538   1.000 34.90779 ? 525 ASP B HB3  1 
ATOM   3351 N N    . LEU B 2 3   ? -22.59449 2.97051   7.13086   1.000 31.61328 ? 526 LEU B N    1 
ATOM   3352 C CA   . LEU B 2 3   ? -22.67643 3.60569   5.82069   1.000 27.55366 ? 526 LEU B CA   1 
ATOM   3353 C C    . LEU B 2 3   ? -21.78560 2.91828   4.79314   1.000 31.42116 ? 526 LEU B C    1 
ATOM   3354 O O    . LEU B 2 3   ? -22.06021 3.00177   3.59026   1.000 26.64239 ? 526 LEU B O    1 
ATOM   3355 C CB   . LEU B 2 3   ? -22.31358 5.08645   5.94075   1.000 27.44978 ? 526 LEU B CB   1 
ATOM   3356 C CG   . LEU B 2 3   ? -23.41134 5.99059   6.51275   1.000 29.45399 ? 526 LEU B CG   1 
ATOM   3357 C CD1  . LEU B 2 3   ? -22.92514 7.43052   6.60696   1.000 34.67680 ? 526 LEU B CD1  1 
ATOM   3358 C CD2  . LEU B 2 3   ? -24.69221 5.92500   5.68231   1.000 31.56687 ? 526 LEU B CD2  1 
ATOM   3359 H H    . LEU B 2 3   ? -22.21585 3.44678   7.73864   1.000 38.38798 ? 526 LEU B H    1 
ATOM   3360 H HA   . LEU B 2 3   ? -23.58893 3.55188   5.49610   1.000 31.88304 ? 526 LEU B HA   1 
ATOM   3361 H HB2  . LEU B 2 3   ? -21.54183 5.16445   6.52317   1.000 30.67949 ? 526 LEU B HB2  1 
ATOM   3362 H HB3  . LEU B 2 3   ? -22.09644 5.41932   5.05591   1.000 30.67949 ? 526 LEU B HB3  1 
ATOM   3363 H HG   . LEU B 2 3   ? -23.62355 5.67203   7.40404   1.000 35.79683 ? 526 LEU B HG   1 
ATOM   3364 H HD11 . LEU B 2 3   ? -23.63537 7.98032   6.97328   1.000 42.06421 ? 526 LEU B HD11 1 
ATOM   3365 H HD12 . LEU B 2 3   ? -22.14824 7.46422   7.18677   1.000 42.06421 ? 526 LEU B HD12 1 
ATOM   3366 H HD13 . LEU B 2 3   ? -22.68932 7.74292   5.71943   1.000 42.06421 ? 526 LEU B HD13 1 
ATOM   3367 H HD21 . LEU B 2 3   ? -25.34694 6.53090   6.06326   1.000 38.33229 ? 526 LEU B HD21 1 
ATOM   3368 H HD22 . LEU B 2 3   ? -24.49093 6.18647   4.77016   1.000 38.33229 ? 526 LEU B HD22 1 
ATOM   3369 H HD23 . LEU B 2 3   ? -25.03298 5.01698   5.69858   1.000 38.33229 ? 526 LEU B HD23 1 
ATOM   3370 N N    . GLU B 2 4   ? -20.72709 2.23696   5.23392   1.000 33.29939 ? 527 GLU B N    1 
ATOM   3371 C CA   . GLU B 2 4   ? -19.87294 1.52802   4.28923   1.000 37.03893 ? 527 GLU B CA   1 
ATOM   3372 C C    . GLU B 2 4   ? -20.61737 0.40947   3.57381   1.000 27.77649 ? 527 GLU B C    1 
ATOM   3373 O O    . GLU B 2 4   ? -20.17163 -0.03453  2.50984   1.000 28.37431 ? 527 GLU B O    1 
ATOM   3374 C CB   . GLU B 2 4   ? -18.64577 0.96716   5.00662   1.000 36.61496 ? 527 GLU B CB   1 
ATOM   3375 C CG   . GLU B 2 4   ? -17.51408 1.97117   5.14287   1.000 27.38273 ? 527 GLU B CG   1 
ATOM   3376 C CD   . GLU B 2 4   ? -16.17668 1.31731   5.42659   1.000 39.37935 ? 527 GLU B CD   1 
ATOM   3377 O OE1  . GLU B 2 4   ? -16.15882 0.26341   6.09610   1.000 38.34669 ? 527 GLU B OE1  1 
ATOM   3378 O OE2  . GLU B 2 4   ? -15.14215 1.86093   4.98395   1.000 37.17582 ? 527 GLU B OE2  1 
ATOM   3379 H H    . GLU B 2 4   ? -20.48864 2.17215   6.05765   1.000 40.41132 ? 527 GLU B H    1 
ATOM   3380 H HA   . GLU B 2 4   ? -19.56171 2.15586   3.61852   1.000 44.89876 ? 527 GLU B HA   1 
ATOM   3381 H HB2  . GLU B 2 4   ? -18.90501 0.68823   5.89875   1.000 44.39001 ? 527 GLU B HB2  1 
ATOM   3382 H HB3  . GLU B 2 4   ? -18.31051 0.20717   4.50571   1.000 44.39001 ? 527 GLU B HB3  1 
ATOM   3383 H HG2  . GLU B 2 4   ? -17.43364 2.47026   4.31502   1.000 30.59903 ? 527 GLU B HG2  1 
ATOM   3384 H HG3  . GLU B 2 4   ? -17.71387 2.57432   5.87581   1.000 30.59903 ? 527 GLU B HG3  1 
ATOM   3385 N N    . THR B 2 5   ? -21.73775 -0.05719  4.12919   1.000 32.72392 ? 528 THR B N    1 
ATOM   3386 C CA   . THR B 2 5   ? -22.56202 -1.03491  3.43119   1.000 30.04042 ? 528 THR B CA   1 
ATOM   3387 C C    . THR B 2 5   ? -23.25984 -0.43990  2.21618   1.000 36.81426 ? 528 THR B C    1 
ATOM   3388 O O    . THR B 2 5   ? -23.81533 -1.19465  1.41096   1.000 27.14688 ? 528 THR B O    1 
ATOM   3389 C CB   . THR B 2 5   ? -23.60781 -1.62799  4.37946   1.000 35.40408 ? 528 THR B CB   1 
ATOM   3390 O OG1  . THR B 2 5   ? -24.55969 -0.61987  4.74197   1.000 30.80091 ? 528 THR B OG1  1 
ATOM   3391 C CG2  . THR B 2 5   ? -22.94446 -2.17736  5.63628   1.000 40.85360 ? 528 THR B CG2  1 
ATOM   3392 H H    . THR B 2 5   ? -22.03637 0.17614   4.90119   1.000 39.72076 ? 528 THR B H    1 
ATOM   3393 H HA   . THR B 2 5   ? -21.99155 -1.76032  3.13247   1.000 36.50055 ? 528 THR B HA   1 
ATOM   3394 H HB   . THR B 2 5   ? -24.06721 -2.35770  3.93520   1.000 42.93694 ? 528 THR B HB   1 
ATOM   3395 H HG1  . THR B 2 5   ? -24.17052 0.01804   5.12565   1.000 37.41314 ? 528 THR B HG1  1 
ATOM   3396 H HG21 . THR B 2 5   ? -23.60679 -2.60585  6.20074   1.000 49.47637 ? 528 THR B HG21 1 
ATOM   3397 H HG22 . THR B 2 5   ? -22.26679 -2.82852  5.39616   1.000 49.47637 ? 528 THR B HG22 1 
ATOM   3398 H HG23 . THR B 2 5   ? -22.52649 -1.45657  6.13292   1.000 49.47637 ? 528 THR B HG23 1 
ATOM   3399 N N    . LEU B 2 6   ? -23.24513 0.88662   2.06795   1.000 31.12007 ? 529 LEU B N    1 
ATOM   3400 C CA   . LEU B 2 6   ? -23.85363 1.55536   0.92992   1.000 33.34425 ? 529 LEU B CA   1 
ATOM   3401 C C    . LEU B 2 6   ? -22.85670 2.31544   0.06658   1.000 27.74292 ? 529 LEU B C    1 
ATOM   3402 O O    . LEU B 2 6   ? -23.23607 2.78114   -1.01387  1.000 33.65063 ? 529 LEU B O    1 
ATOM   3403 C CB   . LEU B 2 6   ? -24.94070 2.53548   1.40165   1.000 32.07269 ? 529 LEU B CB   1 
ATOM   3404 C CG   . LEU B 2 6   ? -25.77224 2.12125   2.61811   1.000 33.89737 ? 529 LEU B CG   1 
ATOM   3405 C CD1  . LEU B 2 6   ? -26.39199 3.34221   3.28059   1.000 41.16234 ? 529 LEU B CD1  1 
ATOM   3406 C CD2  . LEU B 2 6   ? -26.84617 1.11983   2.21831   1.000 35.97624 ? 529 LEU B CD2  1 
ATOM   3407 H H    . LEU B 2 6   ? -22.87974 1.42742   2.62797   1.000 37.79614 ? 529 LEU B H    1 
ATOM   3408 H HA   . LEU B 2 6   ? -24.27971 0.88503   0.37314   1.000 40.46515 ? 529 LEU B HA   1 
ATOM   3409 H HB2  . LEU B 2 6   ? -24.50848 3.37405   1.62720   1.000 37.54822 ? 529 LEU B HB2  1 
ATOM   3410 H HB3  . LEU B 2 6   ? -25.56077 2.66873   0.66771   1.000 37.54822 ? 529 LEU B HB3  1 
ATOM   3411 H HG   . LEU B 2 6   ? -25.19205 1.69145   3.26584   1.000 39.43250 ? 529 LEU B HG   1 
ATOM   3412 H HD11 . LEU B 2 6   ? -26.92517 3.05407   4.03795   1.000 49.84686 ? 529 LEU B HD11 1 
ATOM   3413 H HD12 . LEU B 2 6   ? -25.68325 3.93265   3.58054   1.000 49.84686 ? 529 LEU B HD12 1 
ATOM   3414 H HD13 . LEU B 2 6   ? -26.95356 3.80039   2.63592   1.000 49.84686 ? 529 LEU B HD13 1 
ATOM   3415 H HD21 . LEU B 2 6   ? -27.35252 0.86826   3.00649   1.000 43.62354 ? 529 LEU B HD21 1 
ATOM   3416 H HD22 . LEU B 2 6   ? -27.43367 1.53079   1.56497   1.000 43.62354 ? 529 LEU B HD22 1 
ATOM   3417 H HD23 . LEU B 2 6   ? -26.42089 0.33703   1.83459   1.000 43.62354 ? 529 LEU B HD23 1 
ATOM   3418 N N    . ALA B 2 7   ? -21.60786 2.46191   0.50630   1.000 26.85059 ? 530 ALA B N    1 
ATOM   3419 C CA   . ALA B 2 7   ? -20.62045 3.19772   -0.26613  1.000 38.96455 ? 530 ALA B CA   1 
ATOM   3420 C C    . ALA B 2 7   ? -20.14425 2.37341   -1.46161  1.000 29.10135 ? 530 ALA B C    1 
ATOM   3421 O O    . ALA B 2 7   ? -20.02951 1.14800   -1.37429  1.000 30.93064 ? 530 ALA B O    1 
ATOM   3422 C CB   . ALA B 2 7   ? -19.42845 3.56433   0.60985   1.000 36.40362 ? 530 ALA B CB   1 
ATOM   3423 H H    . ALA B 2 7   ? -21.31049 2.14416   1.24806   1.000 32.67276 ? 530 ALA B H    1 
ATOM   3424 H HA   . ALA B 2 7   ? -21.02055 4.01485   -0.60246  1.000 47.20951 ? 530 ALA B HA   1 
ATOM   3425 H HB1  . ALA B 2 7   ? -18.78224 4.05222   0.07574   1.000 44.13639 ? 530 ALA B HB1  1 
ATOM   3426 H HB2  . ALA B 2 7   ? -19.73519 4.11780   1.34503   1.000 44.13639 ? 530 ALA B HB2  1 
ATOM   3427 H HB3  . ALA B 2 7   ? -19.02693 2.75088   0.95334   1.000 44.13639 ? 530 ALA B HB3  1 
ATOM   3428 N N    . PRO B 2 8   ? -19.85164 3.02289   -2.58918  1.000 27.62432 ? 531 PRO B N    1 
ATOM   3429 C CA   . PRO B 2 8   ? -19.39240 2.27239   -3.76311  1.000 23.20391 ? 531 PRO B CA   1 
ATOM   3430 C C    . PRO B 2 8   ? -18.00592 1.69160   -3.53916  1.000 28.27672 ? 531 PRO B C    1 
ATOM   3431 O O    . PRO B 2 8   ? -17.11384 2.34947   -2.99815  1.000 25.35180 ? 531 PRO B O    1 
ATOM   3432 C CB   . PRO B 2 8   ? -19.39472 3.32013   -4.88175  1.000 23.18963 ? 531 PRO B CB   1 
ATOM   3433 C CG   . PRO B 2 8   ? -19.21784 4.61782   -4.18262  1.000 23.16769 ? 531 PRO B CG   1 
ATOM   3434 C CD   . PRO B 2 8   ? -19.87280 4.47653   -2.83495  1.000 23.24665 ? 531 PRO B CD   1 
ATOM   3435 H HA   . PRO B 2 8   ? -20.01242 1.56015   -3.98489  1.000 28.29675 ? 531 PRO B HA   1 
ATOM   3436 H HB2  . PRO B 2 8   ? -18.66196 3.15207   -5.49471  1.000 28.27960 ? 531 PRO B HB2  1 
ATOM   3437 H HB3  . PRO B 2 8   ? -20.23894 3.29376   -5.35872  1.000 28.27960 ? 531 PRO B HB3  1 
ATOM   3438 H HG2  . PRO B 2 8   ? -18.27137 4.80536   -4.08305  1.000 28.25328 ? 531 PRO B HG2  1 
ATOM   3439 H HG3  . PRO B 2 8   ? -19.64349 5.32244   -4.69568  1.000 28.25328 ? 531 PRO B HG3  1 
ATOM   3440 H HD2  . PRO B 2 8   ? -19.36609 4.94773   -2.15516  1.000 27.74352 ? 531 PRO B HD2  1 
ATOM   3441 H HD3  . PRO B 2 8   ? -20.78406 4.80810   -2.85892  1.000 27.74352 ? 531 PRO B HD3  1 
ATOM   3442 N N    . TYR B 2 9   ? -17.83519 0.44398   -3.96728  1.000 20.84719 ? 532 TYR B N    1 
ATOM   3443 C CA   . TYR B 2 9   ? -16.58546 -0.26692  -3.74269  1.000 21.53797 ? 532 TYR B CA   1 
ATOM   3444 C C    . TYR B 2 9   ? -15.46028 0.31551   -4.58741  1.000 18.85680 ? 532 TYR B C    1 
ATOM   3445 O O    . TYR B 2 9   ? -15.65424 0.67810   -5.75080  1.000 22.37834 ? 532 TYR B O    1 
ATOM   3446 C CB   . TYR B 2 9   ? -16.75930 -1.75111  -4.06913  1.000 21.87757 ? 532 TYR B CB   1 
ATOM   3447 C CG   . TYR B 2 9   ? -15.46621 -2.53944  -4.08523  1.000 22.12727 ? 532 TYR B CG   1 
ATOM   3448 C CD1  . TYR B 2 9   ? -14.89740 -3.00337  -2.90606  1.000 23.61814 ? 532 TYR B CD1  1 
ATOM   3449 C CD2  . TYR B 2 9   ? -14.81744 -2.82405  -5.28018  1.000 22.63678 ? 532 TYR B CD2  1 
ATOM   3450 C CE1  . TYR B 2 9   ? -13.71852 -3.72613  -2.91627  1.000 25.07832 ? 532 TYR B CE1  1 
ATOM   3451 C CE2  . TYR B 2 9   ? -13.63780 -3.54465  -5.29946  1.000 23.71428 ? 532 TYR B CE2  1 
ATOM   3452 C CZ   . TYR B 2 9   ? -13.09371 -3.99322  -4.11486  1.000 24.08439 ? 532 TYR B CZ   1 
ATOM   3453 O OH   . TYR B 2 9   ? -11.92016 -4.71135  -4.12904  1.000 26.85250 ? 532 TYR B OH   1 
ATOM   3454 H H    . TYR B 2 9   ? -18.42883 -0.01215  -4.39052  1.000 24.46376 ? 532 TYR B H    1 
ATOM   3455 H HA   . TYR B 2 9   ? -16.33647 -0.17809  -2.80941  1.000 26.29761 ? 532 TYR B HA   1 
ATOM   3456 H HB2  . TYR B 2 9   ? -17.33847 -2.14976  -3.40090  1.000 24.28818 ? 532 TYR B HB2  1 
ATOM   3457 H HB3  . TYR B 2 9   ? -17.16287 -1.83014  -4.94764  1.000 24.28818 ? 532 TYR B HB3  1 
ATOM   3458 H HD1  . TYR B 2 9   ? -15.31675 -2.82478  -2.09541  1.000 28.79382 ? 532 TYR B HD1  1 
ATOM   3459 H HD2  . TYR B 2 9   ? -15.18306 -2.52460  -6.08115  1.000 26.13944 ? 532 TYR B HD2  1 
ATOM   3460 H HE1  . TYR B 2 9   ? -13.34951 -4.03020  -2.11860  1.000 30.54604 ? 532 TYR B HE1  1 
ATOM   3461 H HE2  . TYR B 2 9   ? -13.21365 -3.72579  -6.10704  1.000 28.90919 ? 532 TYR B HE2  1 
ATOM   3462 H HH   . TYR B 2 9   ? -11.64867 -4.80255  -4.91870  1.000 32.67504 ? 532 TYR B HH   1 
ATOM   3463 N N    . ILE B 2 10  ? -14.27683 0.40366   -3.98958  1.000 18.02190 ? 533 ILE B N    1 
ATOM   3464 C CA   . ILE B 2 10  ? -13.04628 0.67367   -4.72797  1.000 17.14932 ? 533 ILE B CA   1 
ATOM   3465 C C    . ILE B 2 10  ? -12.01644 -0.35751  -4.28214  1.000 18.13280 ? 533 ILE B C    1 
ATOM   3466 O O    . ILE B 2 10  ? -12.03598 -0.77495  -3.11527  1.000 22.70597 ? 533 ILE B O    1 
ATOM   3467 C CB   . ILE B 2 10  ? -12.53876 2.10558   -4.49522  1.000 21.98225 ? 533 ILE B CB   1 
ATOM   3468 C CG1  . ILE B 2 10  ? -12.27783 2.35753   -3.00689  1.000 18.99717 ? 533 ILE B CG1  1 
ATOM   3469 C CG2  . ILE B 2 10  ? -13.53664 3.11654   -5.03944  1.000 22.40071 ? 533 ILE B CG2  1 
ATOM   3470 C CD1  . ILE B 2 10  ? -11.40225 3.56276   -2.74099  1.000 15.62881 ? 533 ILE B CD1  1 
ATOM   3471 H H    . ILE B 2 10  ? -14.15754 0.30945   -3.14312  1.000 20.63412 ? 533 ILE B H    1 
ATOM   3472 H HA   . ILE B 2 10  ? -13.20963 0.57964   -5.67948  1.000 19.55173 ? 533 ILE B HA   1 
ATOM   3473 H HB   . ILE B 2 10  ? -11.69955 2.20799   -4.97075  1.000 26.83074 ? 533 ILE B HB   1 
ATOM   3474 H HG12 . ILE B 2 10  ? -13.12687 2.50340   -2.56107  1.000 23.24865 ? 533 ILE B HG12 1 
ATOM   3475 H HG13 . ILE B 2 10  ? -11.83510 1.58046   -2.63131  1.000 23.24865 ? 533 ILE B HG13 1 
ATOM   3476 H HG21 . ILE B 2 10  ? -13.18607 4.01075   -4.90384  1.000 27.33290 ? 533 ILE B HG21 1 
ATOM   3477 H HG22 . ILE B 2 10  ? -13.66756 2.95266   -5.98649  1.000 27.33290 ? 533 ILE B HG22 1 
ATOM   3478 H HG23 . ILE B 2 10  ? -14.37777 3.01583   -4.56694  1.000 27.33290 ? 533 ILE B HG23 1 
ATOM   3479 H HD11 . ILE B 2 10  ? -11.80905 4.34431   -3.14671  1.000 17.96994 ? 533 ILE B HD11 1 
ATOM   3480 H HD12 . ILE B 2 10  ? -11.32353 3.69066   -1.78269  1.000 17.96994 ? 533 ILE B HD12 1 
ATOM   3481 H HD13 . ILE B 2 10  ? -10.52600 3.40788   -3.12711  1.000 17.96994 ? 533 ILE B HD13 1 
ATOM   3482 N N    . PRO B 2 11  ? -11.10859 -0.79792  -5.15161  1.000 25.15070 ? 534 PRO B N    1 
ATOM   3483 C CA   . PRO B 2 11  ? -10.05351 -1.71050  -4.69738  1.000 23.02128 ? 534 PRO B CA   1 
ATOM   3484 C C    . PRO B 2 11  ? -9.23787  -1.07829  -3.58021  1.000 28.11567 ? 534 PRO B C    1 
ATOM   3485 O O    . PRO B 2 11  ? -8.85481  0.09113   -3.65277  1.000 25.36082 ? 534 PRO B O    1 
ATOM   3486 C CB   . PRO B 2 11  ? -9.21447  -1.93234  -5.96058  1.000 25.27148 ? 534 PRO B CB   1 
ATOM   3487 C CG   . PRO B 2 11  ? -10.17933 -1.69689  -7.07865  1.000 26.82895 ? 534 PRO B CG   1 
ATOM   3488 C CD   . PRO B 2 11  ? -11.01311 -0.54362  -6.59979  1.000 29.56644 ? 534 PRO B CD   1 
ATOM   3489 H HA   . PRO B 2 11  ? -10.42175 -2.55673  -4.39871  1.000 28.07758 ? 534 PRO B HA   1 
ATOM   3490 H HB2  . PRO B 2 11  ? -8.48084  -1.29848  -5.99055  1.000 30.77783 ? 534 PRO B HB2  1 
ATOM   3491 H HB3  . PRO B 2 11  ? -8.87043  -2.83910  -5.97878  1.000 30.77783 ? 534 PRO B HB3  1 
ATOM   3492 H HG2  . PRO B 2 11  ? -9.70114  -1.47006  -7.89154  1.000 32.64679 ? 534 PRO B HG2  1 
ATOM   3493 H HG3  . PRO B 2 11  ? -10.72356 -2.48669  -7.22331  1.000 32.64679 ? 534 PRO B HG3  1 
ATOM   3494 H HD2  . PRO B 2 11  ? -10.57190 0.30198   -6.77643  1.000 35.93177 ? 534 PRO B HD2  1 
ATOM   3495 H HD3  . PRO B 2 11  ? -11.89042 -0.55285  -7.01347  1.000 35.93177 ? 534 PRO B HD3  1 
ATOM   3496 N N    . MET B 2 12  ? -8.96756  -1.86474  -2.53892  1.000 28.83484 ? 535 MET B N    1 
ATOM   3497 C CA   . MET B 2 12  ? -8.23737  -1.36419  -1.38020  1.000 34.85008 ? 535 MET B CA   1 
ATOM   3498 C C    . MET B 2 12  ? -6.76131  -1.74229  -1.39877  1.000 30.36681 ? 535 MET B C    1 
ATOM   3499 O O    . MET B 2 12  ? -5.90651  -0.87017  -1.22522  1.000 38.90031 ? 535 MET B O    1 
ATOM   3500 C CB   . MET B 2 12  ? -8.87886  -1.86484  -0.07892  1.000 35.11322 ? 535 MET B CB   1 
ATOM   3501 C CG   . MET B 2 12  ? -10.19071 -1.17435  0.28408   1.000 32.26435 ? 535 MET B CG   1 
ATOM   3502 S SD   . MET B 2 12  ? -10.05285 0.62483   0.41051   1.000 28.14214 ? 535 MET B SD   1 
ATOM   3503 C CE   . MET B 2 12  ? -8.82521  0.79969   1.70512   1.000 24.21057 ? 535 MET B CE   1 
ATOM   3504 H H    . MET B 2 12  ? -9.19766  -2.69146  -2.48249  1.000 35.05386 ? 535 MET B H    1 
ATOM   3505 H HA   . MET B 2 12  ? -8.30733  -0.39675  -1.38839  1.000 42.27214 ? 535 MET B HA   1 
ATOM   3506 H HB2  . MET B 2 12  ? -9.06171  -2.81316  -0.16919  1.000 42.58791 ? 535 MET B HB2  1 
ATOM   3507 H HB3  . MET B 2 12  ? -8.25689  -1.71482  0.65014   1.000 42.58791 ? 535 MET B HB3  1 
ATOM   3508 H HG2  . MET B 2 12  ? -10.84869 -1.37363  -0.40021  1.000 39.16927 ? 535 MET B HG2  1 
ATOM   3509 H HG3  . MET B 2 12  ? -10.49315 -1.50929  1.14271   1.000 39.16927 ? 535 MET B HG3  1 
ATOM   3510 H HE1  . MET B 2 12  ? -8.71676  1.74105   1.91243   1.000 29.42077 ? 535 MET B HE1  1 
ATOM   3511 H HE2  . MET B 2 12  ? -9.12626  0.32009   2.49268   1.000 29.42077 ? 535 MET B HE2  1 
ATOM   3512 H HE3  . MET B 2 12  ? -7.98381  0.43034   1.39443   1.000 29.42077 ? 535 MET B HE3  1 
ATOM   3513 N N    . ASP B 2 13  ? -6.42842  -3.01776  -1.60276  1.000 52.72060 ? 536 ASP B N    1 
ATOM   3514 C CA   . ASP B 2 13  ? -5.02045  -3.39557  -1.52220  1.000 71.28155 ? 536 ASP B CA   1 
ATOM   3515 C C    . ASP B 2 13  ? -4.27058  -2.92463  -2.76288  1.000 65.01414 ? 536 ASP B C    1 
ATOM   3516 O O    . ASP B 2 13  ? -3.47204  -1.98446  -2.69669  1.000 64.02523 ? 536 ASP B O    1 
ATOM   3517 C CB   . ASP B 2 13  ? -4.89041  -4.91456  -1.37159  1.000 70.56143 ? 536 ASP B CB   1 
ATOM   3518 H H    . ASP B 2 13  ? -6.97743  -3.65507  -1.78172  1.000 63.71677 ? 536 ASP B H    1 
ATOM   3519 H HA   . ASP B 2 13  ? -4.61871  -2.97593  -0.74541  1.000 85.98991 ? 536 ASP B HA   1 
ATOM   3520 N N    . GLY B 2 14  ? -4.52196  -3.57896  -3.89385  1.000 60.84903 ? 537 GLY B N    1 
ATOM   3521 C CA   . GLY B 2 14  ? -4.22788  -3.05514  -5.21045  1.000 56.92343 ? 537 GLY B CA   1 
ATOM   3522 C C    . GLY B 2 14  ? -2.97189  -2.22282  -5.31890  1.000 40.49544 ? 537 GLY B C    1 
ATOM   3523 O O    . GLY B 2 14  ? -1.95367  -2.49524  -4.67579  1.000 45.01950 ? 537 GLY B O    1 
ATOM   3524 H H    . GLY B 2 14  ? -4.87794  -4.36138  -3.92041  1.000 73.47088 ? 537 GLY B H    1 
ATOM   3525 H HA2  . GLY B 2 14  ? -4.13793  -3.80012  -5.82512  1.000 68.76016 ? 537 GLY B HA2  1 
ATOM   3526 H HA3  . GLY B 2 14  ? -4.97100  -2.49984  -5.49386  1.000 68.76016 ? 537 GLY B HA3  1 
ATOM   3527 N N    . GLU B 2 15  ? -3.05263  -1.19015  -6.15557  1.000 61.64385 ? 538 GLU B N    1 
ATOM   3528 C CA   . GLU B 2 15  ? -1.98892  -0.20644  -6.30418  1.000 53.13217 ? 538 GLU B CA   1 
ATOM   3529 C C    . GLU B 2 15  ? -2.47214  1.22040   -6.07307  1.000 42.29572 ? 538 GLU B C    1 
ATOM   3530 O O    . GLU B 2 15  ? -1.96538  1.89497   -5.17253  1.000 48.23633 ? 538 GLU B O    1 
ATOM   3531 C CB   . GLU B 2 15  ? -1.38560  -0.36091  -7.70504  1.000 54.36409 ? 538 GLU B CB   1 
ATOM   3532 H H    . GLU B 2 15  ? -3.73182  -1.03562  -6.65998  1.000 74.42467 ? 538 GLU B H    1 
ATOM   3533 H HA   . GLU B 2 15  ? -1.30331  -0.37216  -5.63833  1.000 64.21065 ? 538 GLU B HA   1 
ATOM   3534 N N    . ASP B 2 16  ? -3.48651  1.67069   -6.82280  1.000 35.74236 ? 539 ASP B N    1 
ATOM   3535 C CA   . ASP B 2 16  ? -3.89521  3.07010   -6.97801  1.000 30.96540 ? 539 ASP B CA   1 
ATOM   3536 C C    . ASP B 2 16  ? -3.10646  3.69404   -8.12582  1.000 25.79284 ? 539 ASP B C    1 
ATOM   3537 O O    . ASP B 2 16  ? -1.97953  3.27674   -8.41058  1.000 25.76303 ? 539 ASP B O    1 
ATOM   3538 C CB   . ASP B 2 16  ? -3.69994  3.91319   -5.70663  1.000 21.58095 ? 539 ASP B CB   1 
ATOM   3539 C CG   . ASP B 2 16  ? -4.64880  3.52532   -4.58809  1.000 16.15280 ? 539 ASP B CG   1 
ATOM   3540 O OD1  . ASP B 2 16  ? -5.70561  2.93651   -4.88277  1.000 15.70615 ? 539 ASP B OD1  1 
ATOM   3541 O OD2  . ASP B 2 16  ? -4.34167  3.83082   -3.41529  1.000 25.55398 ? 539 ASP B OD2  1 
ATOM   3542 H H    . ASP B 2 16  ? -3.98899  1.14705   -7.28422  1.000 43.34288 ? 539 ASP B H    1 
ATOM   3543 H HA   . ASP B 2 16  ? -4.84759  3.08119   -7.16173  1.000 37.61053 ? 539 ASP B HA   1 
ATOM   3544 H HB2  . ASP B 2 16  ? -2.79289  3.79283   -5.38465  1.000 26.34919 ? 539 ASP B HB2  1 
ATOM   3545 H HB3  . ASP B 2 16  ? -3.85504  4.84657   -5.92028  1.000 26.34919 ? 539 ASP B HB3  1 
ATOM   3546 N N    A PHE B 2 17  ? -3.68490  4.69294   -8.78611  0.170 25.42370 ? 540 PHE B N    1 
ATOM   3547 N N    B PHE B 2 17  ? -3.68461  4.69237   -8.78716  0.830 25.54789 ? 540 PHE B N    1 
ATOM   3548 C CA   A PHE B 2 17  ? -2.98901  5.43228   -9.82992  0.170 20.33921 ? 540 PHE B CA   1 
ATOM   3549 C CA   B PHE B 2 17  ? -2.98858  5.43167   -9.83117  0.830 19.87060 ? 540 PHE B CA   1 
ATOM   3550 C C    A PHE B 2 17  ? -2.32941  6.66025   -9.21747  0.170 21.79324 ? 540 PHE B C    1 
ATOM   3551 C C    B PHE B 2 17  ? -2.32966  6.66025   -9.21919  0.830 21.81214 ? 540 PHE B C    1 
ATOM   3552 O O    A PHE B 2 17  ? -2.98970  7.45133   -8.53706  0.170 20.67817 ? 540 PHE B O    1 
ATOM   3553 O O    B PHE B 2 17  ? -2.99155  7.45288   -8.54252  0.830 20.78787 ? 540 PHE B O    1 
ATOM   3554 C CB   A PHE B 2 17  ? -3.95434  5.84716   -10.93920 0.170 17.78423 ? 540 PHE B CB   1 
ATOM   3555 C CB   B PHE B 2 17  ? -3.95456  5.84703   -10.93952 0.830 18.63982 ? 540 PHE B CB   1 
ATOM   3556 C CG   A PHE B 2 17  ? -3.29232  6.56808   -12.07941 0.170 23.58183 ? 540 PHE B CG   1 
ATOM   3557 C CG   B PHE B 2 17  ? -3.29391  6.56773   -12.07991 0.830 23.27462 ? 540 PHE B CG   1 
ATOM   3558 C CD1  A PHE B 2 17  ? -2.75776  5.86478   -13.14616 0.170 23.82875 ? 540 PHE B CD1  1 
ATOM   3559 C CD1  B PHE B 2 17  ? -2.78072  5.86549   -13.15782 0.830 24.01605 ? 540 PHE B CD1  1 
ATOM   3560 C CD2  A PHE B 2 17  ? -3.20235  7.95028   -12.08286 0.170 24.80322 ? 540 PHE B CD2  1 
ATOM   3561 C CD2  B PHE B 2 17  ? -3.18449  7.94872   -12.07337 0.830 25.06079 ? 540 PHE B CD2  1 
ATOM   3562 C CE1  A PHE B 2 17  ? -2.14880  6.52718   -14.19597 0.170 24.19830 ? 540 PHE B CE1  1 
ATOM   3563 C CE1  B PHE B 2 17  ? -2.17352  6.52716   -14.20812 0.830 24.31199 ? 540 PHE B CE1  1 
ATOM   3564 C CE2  A PHE B 2 17  ? -2.59440  8.61742   -13.12928 0.170 22.71645 ? 540 PHE B CE2  1 
ATOM   3565 C CE2  B PHE B 2 17  ? -2.57811  8.61520   -13.12060 0.830 22.64780 ? 540 PHE B CE2  1 
ATOM   3566 C CZ   A PHE B 2 17  ? -2.06704  7.90528   -14.18654 0.170 25.57913 ? 540 PHE B CZ   1 
ATOM   3567 C CZ   B PHE B 2 17  ? -2.07191  7.90407   -14.18829 0.830 25.71268 ? 540 PHE B CZ   1 
ATOM   3568 H H    A PHE B 2 17  ? -4.48903  4.96320   -8.64492  0.170 30.96048 ? 540 PHE B H    1 
ATOM   3569 H H    B PHE B 2 17  ? -4.48891  4.96244   -8.64661  0.830 31.10952 ? 540 PHE B H    1 
ATOM   3570 H HA   A PHE B 2 17  ? -2.30360  4.87167   -10.22595 0.170 24.85909 ? 540 PHE B HA   1 
ATOM   3571 H HA   B PHE B 2 17  ? -2.30311  4.87096   -10.22695 0.830 24.29677 ? 540 PHE B HA   1 
ATOM   3572 H HB2  A PHE B 2 17  ? -4.37775  5.05156   -11.29788 0.170 21.79313 ? 540 PHE B HB2  1 
ATOM   3573 H HB2  B PHE B 2 17  ? -4.37850  5.05160   -11.29794 0.830 22.81983 ? 540 PHE B HB2  1 
ATOM   3574 H HB3  A PHE B 2 17  ? -4.62477  6.43925   -10.56391 0.170 21.79313 ? 540 PHE B HB3  1 
ATOM   3575 H HB3  B PHE B 2 17  ? -4.62450  6.43923   -10.56352 0.830 22.81983 ? 540 PHE B HB3  1 
ATOM   3576 H HD1  A PHE B 2 17  ? -2.80902  4.93625   -13.15643 0.170 29.04655 ? 540 PHE B HD1  1 
ATOM   3577 H HD1  B PHE B 2 17  ? -2.84553  4.93791   -13.17494 0.830 29.27130 ? 540 PHE B HD1  1 
ATOM   3578 H HD2  A PHE B 2 17  ? -3.55541  8.43530   -11.37222 0.170 30.21592 ? 540 PHE B HD2  1 
ATOM   3579 H HD2  B PHE B 2 17  ? -3.52333  8.43299   -11.35534 0.830 30.52499 ? 540 PHE B HD2  1 
ATOM   3580 H HE1  A PHE B 2 17  ? -1.79459  6.04480   -14.90783 0.170 29.49001 ? 540 PHE B HE1  1 
ATOM   3581 H HE1  B PHE B 2 17  ? -1.83371  6.04561   -14.92752 0.830 29.62644 ? 540 PHE B HE1  1 
ATOM   3582 H HE2  A PHE B 2 17  ? -2.54082  9.54583   -13.12076 0.170 27.71179 ? 540 PHE B HE2  1 
ATOM   3583 H HE2  B PHE B 2 17  ? -2.51133  9.54268   -13.10558 0.830 27.62941 ? 540 PHE B HE2  1 
ATOM   3584 H HZ   A PHE B 2 17  ? -1.65730  8.35260   -14.89147 0.170 31.14701 ? 540 PHE B HZ   1 
ATOM   3585 H HZ   B PHE B 2 17  ? -1.66280  8.35114   -14.89373 0.830 31.30727 ? 540 PHE B HZ   1 
ATOM   3586 N N    . GLN B 2 18  ? -1.03244  6.81674   -9.46172  1.000 22.27596 ? 541 GLN B N    1 
ATOM   3587 C CA   . GLN B 2 18  ? -0.25353  7.90821   -8.89305  1.000 23.40414 ? 541 GLN B CA   1 
ATOM   3588 C C    . GLN B 2 18  ? -0.14599  9.03901   -9.90697  1.000 14.16217 ? 541 GLN B C    1 
ATOM   3589 O O    . GLN B 2 18  ? 0.22699   8.80961   -11.06234 1.000 19.36278 ? 541 GLN B O    1 
ATOM   3590 C CB   . GLN B 2 18  ? 1.13697   7.42107   -8.48369  1.000 26.44926 ? 541 GLN B CB   1 
ATOM   3591 C CG   . GLN B 2 18  ? 1.12318   6.13817   -7.66059  1.000 27.17800 ? 541 GLN B CG   1 
ATOM   3592 C CD   . GLN B 2 18  ? 0.46836   6.31789   -6.30570  1.000 27.06024 ? 541 GLN B CD   1 
ATOM   3593 O OE1  . GLN B 2 18  ? -0.52899  5.66619   -5.99461  1.000 32.34572 ? 541 GLN B OE1  1 
ATOM   3594 N NE2  . GLN B 2 18  ? 1.02747   7.20495   -5.49059  1.000 33.06587 ? 541 GLN B NE2  1 
ATOM   3595 H H    . GLN B 2 18  ? -0.57026  6.29282   -9.96322  1.000 27.18320 ? 541 GLN B H    1 
ATOM   3596 H HA   . GLN B 2 18  ? -0.69945  8.25239   -8.10337  1.000 28.53702 ? 541 GLN B HA   1 
ATOM   3597 H HB2  . GLN B 2 18  ? 1.65639   7.25250   -9.28537  1.000 32.19116 ? 541 GLN B HB2  1 
ATOM   3598 H HB3  . GLN B 2 18  ? 1.56380   8.10990   -7.95056  1.000 32.19116 ? 541 GLN B HB3  1 
ATOM   3599 H HG2  . GLN B 2 18  ? 0.62960   5.45754   -8.14434  1.000 33.06564 ? 541 GLN B HG2  1 
ATOM   3600 H HG3  . GLN B 2 18  ? 2.03663   5.84568   -7.51581  1.000 33.06564 ? 541 GLN B HG3  1 
ATOM   3601 H HE21 . GLN B 2 18  ? 1.72427   7.64135   -5.74284  1.000 40.13110 ? 541 GLN B HE21 1 
ATOM   3602 H HE22 . GLN B 2 18  ? 0.69272   7.34295   -4.71053  1.000 40.13110 ? 541 GLN B HE22 1 
ATOM   3603 N N    . LEU B 2 19  ? -0.47064  10.25301  -9.46971  1.000 26.48262 ? 542 LEU B N    1 
ATOM   3604 C CA   . LEU B 2 19  ? -0.49807  11.41424  -10.35311 1.000 15.23860 ? 542 LEU B CA   1 
ATOM   3605 C C    . LEU B 2 19  ? 0.87832   12.05493  -10.48648 1.000 23.90030 ? 542 LEU B C    1 
ATOM   3606 O O    . LEU B 2 19  ? 1.12537   12.81916  -11.42110 1.000 20.02162 ? 542 LEU B O    1 
ATOM   3607 C CB   . LEU B 2 19  ? -1.49816  12.45288  -9.83790  1.000 17.02876 ? 542 LEU B CB   1 
ATOM   3608 C CG   . LEU B 2 19  ? -2.94392  11.98238  -9.66999  1.000 13.70608 ? 542 LEU B CG   1 
ATOM   3609 C CD1  . LEU B 2 19  ? -3.81105  13.09199  -9.09660  1.000 31.61667 ? 542 LEU B CD1  1 
ATOM   3610 C CD2  . LEU B 2 19  ? -3.51044  11.48879  -10.99076 1.000 24.87578 ? 542 LEU B CD2  1 
ATOM   3611 O OXT  . LEU B 2 19  ? 1.76843   11.83367  -9.66600  1.000 13.09340 ? 542 LEU B OXT  1 
ATOM   3612 H H    . LEU B 2 19  ? -0.68163  10.43223  -8.65549  1.000 32.23120 ? 542 LEU B H    1 
ATOM   3613 H HA   . LEU B 2 19  ? -0.77740  11.12140  -11.23465 1.000 18.73837 ? 542 LEU B HA   1 
ATOM   3614 H HB2  . LEU B 2 19  ? -1.19444  12.75709  -8.96835  1.000 20.88656 ? 542 LEU B HB2  1 
ATOM   3615 H HB3  . LEU B 2 19  ? -1.51035  13.19438  -10.46314 1.000 20.88656 ? 542 LEU B HB3  1 
ATOM   3616 H HG   . LEU B 2 19  ? -2.95602  11.24064  -9.04504  1.000 16.89934 ? 542 LEU B HG   1 
ATOM   3617 H HD11 . LEU B 2 19  ? -4.71830  12.76382  -8.99614  1.000 38.39205 ? 542 LEU B HD11 1 
ATOM   3618 H HD12 . LEU B 2 19  ? -3.45690  13.35508  -8.23274  1.000 38.39205 ? 542 LEU B HD12 1 
ATOM   3619 H HD13 . LEU B 2 19  ? -3.79823  13.84844  -9.70365  1.000 38.39205 ? 542 LEU B HD13 1 
ATOM   3620 H HD21 . LEU B 2 19  ? -4.45835  11.31396  -10.88216 1.000 30.30298 ? 542 LEU B HD21 1 
ATOM   3621 H HD22 . LEU B 2 19  ? -3.37524  12.17092  -11.66701 1.000 30.30298 ? 542 LEU B HD22 1 
ATOM   3622 H HD23 . LEU B 2 19  ? -3.05094  10.67373  -11.24658 1.000 30.30298 ? 542 LEU B HD23 1 
HETATM 3623 C C    . ACT C 3 .   ? -23.77435 9.39023   -10.81273 1.000 24.66038 ? 501 ACT A C    1 
HETATM 3624 O O    . ACT C 3 .   ? -23.51273 8.45275   -11.61396 1.000 23.16314 ? 501 ACT A O    1 
HETATM 3625 O OXT  . ACT C 3 .   ? -24.46241 10.43016  -11.01120 1.000 34.02032 ? 501 ACT A OXT  1 
HETATM 3626 C CH3  . ACT C 3 .   ? -23.17150 9.27016   -9.38114  1.000 31.54359 ? 501 ACT A CH3  1 
HETATM 3627 H H1   . ACT C 3 .   ? -22.50278 8.56759   -9.37050  1.000 38.30435 ? 501 ACT A H1   1 
HETATM 3628 H H2   . ACT C 3 .   ? -23.87694 9.05556   -8.75090  1.000 38.30435 ? 501 ACT A H2   1 
HETATM 3629 H H3   . ACT C 3 .   ? -22.76019 10.11272  -9.13251  1.000 38.30435 ? 501 ACT A H3   1 
HETATM 3630 O O    . HOH D 4 .   ? -28.10292 8.92679   -25.87412 1.000 33.15151 ? 601 HOH A O    1 
HETATM 3631 O O    . HOH D 4 .   ? -24.72024 25.71104  6.40737   1.000 34.90765 ? 602 HOH A O    1 
HETATM 3632 O O    . HOH D 4 .   ? -9.03753  13.51310  4.94235   1.000 28.15442 ? 603 HOH A O    1 
HETATM 3633 O O    . HOH D 4 .   ? 0.60611   15.30129  4.60658   1.000 31.56263 ? 604 HOH A O    1 
HETATM 3634 O O    . HOH D 4 .   ? -7.58707  21.22986  -21.35728 1.000 33.18656 ? 605 HOH A O    1 
HETATM 3635 O O    . HOH D 4 .   ? -0.14367  11.07593  -13.64789 1.000 34.06284 ? 606 HOH A O    1 
HETATM 3636 O O    . HOH D 4 .   ? -31.98211 16.10480  -19.86736 1.000 33.79242 ? 607 HOH A O    1 
HETATM 3637 O O    . HOH D 4 .   ? -22.69686 19.73187  -19.96286 1.000 31.32138 ? 608 HOH A O    1 
HETATM 3638 O O    . HOH D 4 .   ? -26.76709 -10.38431 -9.57127  1.000 32.88398 ? 609 HOH A O    1 
HETATM 3639 O O    . HOH D 4 .   ? -22.47942 5.53028   1.97429   1.000 31.23842 ? 610 HOH A O    1 
HETATM 3640 O O    . HOH D 4 .   ? -5.83360  19.25772  -19.92107 1.000 25.21441 ? 611 HOH A O    1 
HETATM 3641 O O    . HOH D 4 .   ? -12.29800 11.29675  5.73678   1.000 28.66147 ? 612 HOH A O    1 
HETATM 3642 O O    . HOH D 4 .   ? -10.77364 -3.71134  -16.50781 1.000 26.92528 ? 613 HOH A O    1 
HETATM 3643 O O    . HOH D 4 .   ? -20.15636 11.47394  -0.40366  1.000 19.41957 ? 614 HOH A O    1 
HETATM 3644 O O    . HOH D 4 .   ? -2.53498  11.83520  -15.83336 1.000 20.44113 ? 615 HOH A O    1 
HETATM 3645 O O    . HOH D 4 .   ? -31.86875 -3.55181  -17.24640 1.000 39.74668 ? 616 HOH A O    1 
HETATM 3646 O O    . HOH D 4 .   ? -14.52598 17.40647  -28.47318 1.000 31.45789 ? 617 HOH A O    1 
HETATM 3647 O O    . HOH D 4 .   ? -2.94893  8.20467   -2.32737  1.000 28.76331 ? 618 HOH A O    1 
HETATM 3648 O O    . HOH D 4 .   ? -1.98095  10.74484  9.53913   1.000 35.07494 ? 619 HOH A O    1 
HETATM 3649 O O    . HOH D 4 .   ? -0.61259  24.86102  -17.11147 1.000 12.78987 ? 620 HOH A O    1 
HETATM 3650 O O    . HOH D 4 .   ? -5.64982  20.21652  -2.16468  1.000 18.35272 ? 621 HOH A O    1 
HETATM 3651 O O    . HOH D 4 .   ? -19.33755 -7.13471  -10.12973 1.000 23.52917 ? 622 HOH A O    1 
HETATM 3652 O O    . HOH D 4 .   ? -20.81678 -5.52071  -2.39547  1.000 22.31086 ? 623 HOH A O    1 
HETATM 3653 O O    . HOH D 4 .   ? -10.98215 28.83389  -2.46038  1.000 18.64932 ? 624 HOH A O    1 
HETATM 3654 O O    . HOH D 4 .   ? -19.62981 6.31089   -13.01412 1.000 31.93327 ? 625 HOH A O    1 
HETATM 3655 O O    . HOH D 4 .   ? 1.70529   10.92497  -6.80969  1.000 23.71371 ? 626 HOH A O    1 
HETATM 3656 O O    . HOH D 4 .   ? -29.21679 21.85174  -11.49494 1.000 28.03376 ? 627 HOH A O    1 
HETATM 3657 O O    . HOH D 4 .   ? -15.12257 1.62813   8.72764   1.000 34.87160 ? 628 HOH A O    1 
HETATM 3658 O O    . HOH D 4 .   ? -12.58628 20.17053  2.59609   1.000 26.63871 ? 629 HOH A O    1 
HETATM 3659 O O    . HOH D 4 .   ? -36.27926 9.47138   -11.76918 1.000 24.22957 ? 630 HOH A O    1 
HETATM 3660 O O    . HOH D 4 .   ? -16.57345 -5.52602  -14.20818 1.000 24.82064 ? 631 HOH A O    1 
HETATM 3661 O O    . HOH D 4 .   ? -29.51798 15.86603  -29.21386 1.000 36.94022 ? 632 HOH A O    1 
HETATM 3662 O O    . HOH D 4 .   ? -12.56437 33.47372  -14.47105 1.000 31.10616 ? 633 HOH A O    1 
HETATM 3663 O O    . HOH D 4 .   ? -20.81613 20.12184  0.08090   1.000 18.78935 ? 634 HOH A O    1 
HETATM 3664 O O    . HOH D 4 .   ? -22.18500 6.19455   -12.23561 1.000 32.77640 ? 635 HOH A O    1 
HETATM 3665 O O    . HOH D 4 .   ? -10.96989 20.93940  -24.11204 1.000 32.59796 ? 636 HOH A O    1 
HETATM 3666 O O    . HOH D 4 .   ? -8.99956  -3.09416  -18.51069 1.000 22.56267 ? 637 HOH A O    1 
HETATM 3667 O O    . HOH D 4 .   ? -14.46035 0.65424   -25.93938 1.000 29.84076 ? 638 HOH A O    1 
HETATM 3668 O O    . HOH D 4 .   ? -14.12274 14.62707  0.89232   1.000 14.16544 ? 639 HOH A O    1 
HETATM 3669 O O    . HOH D 4 .   ? -4.37242  13.26314  -22.38154 1.000 30.95703 ? 640 HOH A O    1 
HETATM 3670 O O    . HOH D 4 .   ? -12.77303 22.46131  -21.01442 1.000 40.12654 ? 641 HOH A O    1 
HETATM 3671 O O    . HOH D 4 .   ? -22.02794 6.95010   -6.11185  1.000 24.92578 ? 642 HOH A O    1 
HETATM 3672 O O    . HOH D 4 .   ? -28.71275 19.92108  -14.26384 1.000 31.12516 ? 643 HOH A O    1 
HETATM 3673 O O    . HOH D 4 .   ? -12.15949 33.19159  -9.06224  1.000 21.42968 ? 644 HOH A O    1 
HETATM 3674 O O    . HOH D 4 .   ? -3.69562  18.41744  -3.56294  1.000 23.16423 ? 645 HOH A O    1 
HETATM 3675 O O    . HOH D 4 .   ? -7.88701  6.25232   6.89662   1.000 35.31298 ? 646 HOH A O    1 
HETATM 3676 O O    . HOH D 4 .   ? -24.47727 6.00642   -15.23233 1.000 28.88245 ? 647 HOH A O    1 
HETATM 3677 O O    . HOH D 4 .   ? -6.10659  14.12912  5.90952   1.000 27.66771 ? 648 HOH A O    1 
HETATM 3678 O O    . HOH D 4 .   ? -1.29264  18.74004  -18.53377 1.000 28.97897 ? 649 HOH A O    1 
HETATM 3679 O O    . HOH D 4 .   ? -0.81513  18.08051  -15.47977 1.000 21.57203 ? 650 HOH A O    1 
HETATM 3680 O O    . HOH D 4 .   ? -2.89434  13.99248  -16.89884 1.000 25.14772 ? 651 HOH A O    1 
HETATM 3681 O O    . HOH D 4 .   ? -20.89667 24.77956  -10.11799 1.000 25.52743 ? 652 HOH A O    1 
HETATM 3682 O O    . HOH D 4 .   ? -13.22269 1.52414   0.79138   1.000 27.61444 ? 653 HOH A O    1 
HETATM 3683 O O    . HOH D 4 .   ? -5.78452  31.75421  -14.31796 1.000 24.40806 ? 654 HOH A O    1 
HETATM 3684 O O    . HOH D 4 .   ? -8.88132  -2.22182  -15.57414 1.000 26.91652 ? 655 HOH A O    1 
HETATM 3685 O O    . HOH D 4 .   ? -1.25893  13.30261  -20.20759 1.000 33.78659 ? 656 HOH A O    1 
HETATM 3686 O O    . HOH D 4 .   ? -0.99128  8.11245   -0.45724  1.000 27.67783 ? 657 HOH A O    1 
HETATM 3687 O O    . HOH D 4 .   ? -0.77989  23.15072  -8.51274  1.000 27.67731 ? 658 HOH A O    1 
HETATM 3688 O O    . HOH D 4 .   ? -18.05795 -1.61133  -7.24239  1.000 22.55975 ? 659 HOH A O    1 
HETATM 3689 O O    . HOH D 4 .   ? -8.37354  1.42716   -8.77810  1.000 14.70771 ? 660 HOH A O    1 
HETATM 3690 O O    . HOH D 4 .   ? -20.36826 8.86678   -6.99124  1.000 19.95542 ? 661 HOH A O    1 
HETATM 3691 O O    . HOH D 4 .   ? -23.46849 -8.72084  -7.23268  1.000 29.67422 ? 662 HOH A O    1 
HETATM 3692 O O    . HOH D 4 .   ? -5.80945  4.23156   -13.92275 1.000 21.00415 ? 663 HOH A O    1 
HETATM 3693 O O    . HOH D 4 .   ? -9.32249  0.73967   5.84163   1.000 21.01026 ? 664 HOH A O    1 
HETATM 3694 O O    . HOH D 4 .   ? -10.23046 19.35448  4.23810   1.000 31.83549 ? 665 HOH A O    1 
HETATM 3695 O O    . HOH D 4 .   ? -30.04971 -3.88622  -11.87480 1.000 30.77380 ? 666 HOH A O    1 
HETATM 3696 O O    . HOH D 4 .   ? -21.78975 24.28120  -25.94882 1.000 25.12757 ? 667 HOH A O    1 
HETATM 3697 O O    . HOH D 4 .   ? -28.92804 19.72035  0.74518   1.000 21.99479 ? 668 HOH A O    1 
HETATM 3698 O O    . HOH D 4 .   ? -25.04843 8.93288   -25.72328 1.000 32.48062 ? 669 HOH A O    1 
HETATM 3699 O O    . HOH D 4 .   ? -28.91435 26.53829  -0.95412  1.000 33.73662 ? 670 HOH A O    1 
HETATM 3700 O O    . HOH D 4 .   ? -38.61683 -2.26472  -15.58785 1.000 27.89152 ? 671 HOH A O    1 
HETATM 3701 O O    . HOH D 4 .   ? -1.16253  9.27857   7.88080   1.000 35.79758 ? 672 HOH A O    1 
HETATM 3702 O O    . HOH D 4 .   ? -27.97464 7.84382   5.18986   1.000 39.40872 ? 673 HOH A O    1 
HETATM 3703 O O    . HOH D 4 .   ? -20.52878 25.41070  -16.35949 1.000 24.22613 ? 674 HOH A O    1 
HETATM 3704 O O    . HOH D 4 .   ? -13.75819 31.95599  -13.47319 1.000 35.70879 ? 675 HOH A O    1 
HETATM 3705 O O    . HOH D 4 .   ? -9.05148  19.94053  -23.44274 1.000 33.29553 ? 676 HOH A O    1 
HETATM 3706 O O    . HOH D 4 .   ? -22.78970 -9.93829  -12.94690 1.000 33.02389 ? 677 HOH A O    1 
HETATM 3707 O O    . HOH D 4 .   ? -10.62497 2.14615   4.48992   1.000 26.34862 ? 678 HOH A O    1 
HETATM 3708 O O    . HOH D 4 .   ? -21.00292 5.47439   -7.58161  1.000 26.58584 ? 679 HOH A O    1 
HETATM 3709 O O    . HOH E 4 .   ? -17.71527 0.80100   -7.27200  1.000 16.74067 ? 601 HOH B O    1 
HETATM 3710 O O    . HOH E 4 .   ? 2.75326   9.07646   -6.05532  1.000 43.29938 ? 602 HOH B O    1 
HETATM 3711 O O    . HOH E 4 .   ? -13.74478 -0.46164  -1.11603  1.000 26.09729 ? 603 HOH B O    1 
HETATM 3712 O O    . HOH E 4 .   ? -23.81411 -3.82205  0.49690   1.000 37.63604 ? 604 HOH B O    1 
HETATM 3713 O O    . HOH E 4 .   ? -8.54379  1.99574   -5.67313  1.000 21.79442 ? 605 HOH B O    1 
HETATM 3714 O O    . HOH E 4 .   ? 0.96712   6.25377   -12.11057 1.000 25.38018 ? 606 HOH B O    1 
HETATM 3715 O O    . HOH E 4 .   ? -10.39020 -4.24797  -1.64836  1.000 24.05090 ? 607 HOH B O    1 
HETATM 3716 O O    . HOH E 4 .   ? -12.912   -7.535    -1.355    1.000 28.76382 ? 608 HOH B O    1 
# 
loop_
_atom_site_anisotrop.id 
_atom_site_anisotrop.type_symbol 
_atom_site_anisotrop.pdbx_label_atom_id 
_atom_site_anisotrop.pdbx_label_alt_id 
_atom_site_anisotrop.pdbx_label_comp_id 
_atom_site_anisotrop.pdbx_label_asym_id 
_atom_site_anisotrop.pdbx_label_seq_id 
_atom_site_anisotrop.pdbx_PDB_ins_code 
_atom_site_anisotrop.U[1][1] 
_atom_site_anisotrop.U[2][2] 
_atom_site_anisotrop.U[3][3] 
_atom_site_anisotrop.U[1][2] 
_atom_site_anisotrop.U[1][3] 
_atom_site_anisotrop.U[2][3] 
_atom_site_anisotrop.pdbx_auth_seq_id 
_atom_site_anisotrop.pdbx_auth_comp_id 
_atom_site_anisotrop.pdbx_auth_asym_id 
_atom_site_anisotrop.pdbx_auth_atom_id 
1    N N   . LEU A 8   ? 0.92634 0.80093 0.83156 -0.07270 -0.16214 0.06660  188 LEU A N   
2    C CA  . LEU A 8   ? 0.99950 0.87432 0.90346 -0.07587 -0.15976 0.06899  188 LEU A CA  
3    C C   . LEU A 8   ? 0.77516 0.67586 0.66789 -0.07081 -0.14234 0.06407  188 LEU A C   
4    O O   . LEU A 8   ? 0.64267 0.56077 0.53726 -0.06142 -0.13386 0.05974  188 LEU A O   
5    C CB  . LEU A 8   ? 0.98341 0.85109 0.92162 -0.07003 -0.16821 0.07309  188 LEU A CB  
8    N N   . PRO A 9   ? 0.63984 0.54166 0.52119 -0.07710 -0.13804 0.06476  189 PRO A N   
9    C CA  . PRO A 9   ? 0.53078 0.45768 0.40443 -0.07262 -0.12193 0.05989  189 PRO A CA  
10   C C   . PRO A 9   ? 0.38245 0.32113 0.27681 -0.05875 -0.11681 0.06098  189 PRO A C   
11   O O   . PRO A 9   ? 0.49009 0.41805 0.40509 -0.05543 -0.12314 0.06639  189 PRO A O   
12   C CB  . PRO A 9   ? 0.63244 0.55135 0.49573 -0.08267 -0.12180 0.06238  189 PRO A CB  
13   C CG  . PRO A 9   ? 0.70343 0.59140 0.56904 -0.09128 -0.13911 0.06904  189 PRO A CG  
14   C CD  . PRO A 9   ? 0.67558 0.55348 0.55113 -0.08868 -0.14913 0.07016  189 PRO A CD  
22   N N   . ALA A 10  ? 0.50549 0.46592 0.39481 -0.05066 -0.10549 0.05554  190 ALA A N   
23   C CA  . ALA A 10  ? 0.33810 0.30654 0.24330 -0.03814 -0.10062 0.05766  190 ALA A CA  
24   C C   . ALA A 10  ? 0.36304 0.33512 0.27150 -0.03772 -0.09393 0.06084  190 ALA A C   
25   O O   . ALA A 10  ? 0.33100 0.29722 0.25732 -0.03176 -0.09425 0.06643  190 ALA A O   
26   C CB  . ALA A 10  ? 0.28516 0.27249 0.18159 -0.02970 -0.09285 0.05115  190 ALA A CB  
32   N N   . LEU A 11  ? 0.28095 0.26173 0.17325 -0.04444 -0.08713 0.05712  191 LEU A N   
33   C CA  . LEU A 11  ? 0.28740 0.27278 0.17970 -0.04425 -0.07938 0.05881  191 LEU A CA  
34   C C   . LEU A 11  ? 0.24387 0.20884 0.14839 -0.04730 -0.08773 0.06660  191 LEU A C   
35   O O   . LEU A 11  ? 0.28257 0.24597 0.19798 -0.04175 -0.08400 0.07110  191 LEU A O   
36   C CB  . LEU A 11  ? 0.37596 0.37168 0.25201 -0.05203 -0.07217 0.05293  191 LEU A CB  
37   C CG  . LEU A 11  ? 0.31250 0.31211 0.18685 -0.05373 -0.06434 0.05340  191 LEU A CG  
38   C CD1 . LEU A 11  ? 0.25069 0.26183 0.13139 -0.04289 -0.05585 0.05312  191 LEU A CD1 
39   C CD2 . LEU A 11  ? 0.28708 0.29652 0.14937 -0.06187 -0.05866 0.04754  191 LEU A CD2 
51   N N   . LYS A 12  ? 0.42907 0.37630 0.33217 -0.05607 -0.09955 0.06837  192 LYS A N   
52   C CA  . LYS A 12  ? 0.39607 0.32301 0.31351 -0.05757 -0.11027 0.07437  192 LYS A CA  
53   C C   . LYS A 12  ? 0.31351 0.23528 0.26315 -0.04669 -0.11531 0.07826  192 LYS A C   
54   O O   . LYS A 12  ? 0.44977 0.36638 0.41862 -0.04100 -0.11305 0.08210  192 LYS A O   
55   C CB  . LYS A 12  ? 0.40105 0.30750 0.31053 -0.06883 -0.12432 0.07502  192 LYS A CB  
56   C CG  . LYS A 12  ? 0.41230 0.29710 0.34126 -0.06847 -0.13938 0.07942  192 LYS A CG  
57   C CD  . LYS A 12  ? 0.44722 0.30857 0.36221 -0.08130 -0.15420 0.08016  192 LYS A CD  
64   N N   . LEU A 13  ? 0.26489 0.18757 0.22312 -0.04366 -0.11983 0.07657  193 LEU A N   
65   C CA  . LEU A 13  ? 0.38850 0.30800 0.38169 -0.03405 -0.12241 0.07836  193 LEU A CA  
66   C C   . LEU A 13  ? 0.23156 0.16011 0.23390 -0.02480 -0.10744 0.08054  193 LEU A C   
67   O O   . LEU A 13  ? 0.42743 0.35009 0.46090 -0.01892 -0.10326 0.08215  193 LEU A O   
68   C CB  . LEU A 13  ? 0.34185 0.26089 0.33604 -0.03403 -0.12831 0.07557  193 LEU A CB  
69   C CG  . LEU A 13  ? 0.31040 0.22720 0.34088 -0.02635 -0.13045 0.07557  193 LEU A CG  
70   C CD1 . LEU A 13  ? 0.28882 0.19647 0.35197 -0.02727 -0.14076 0.07574  193 LEU A CD1 
71   C CD2 . LEU A 13  ? 0.33391 0.24890 0.35677 -0.02783 -0.13596 0.07305  193 LEU A CD2 
83   N N   . ALA A 14  ? 0.30920 0.25177 0.28619 -0.02403 -0.09747 0.07912  194 ALA A N   
84   C CA  . ALA A 14  ? 0.33199 0.28098 0.31283 -0.01695 -0.08269 0.08029  194 ALA A CA  
85   C C   . ALA A 14  ? 0.32134 0.26694 0.30392 -0.01925 -0.07240 0.08157  194 ALA A C   
86   O O   . ALA A 14  ? 0.24644 0.18711 0.25070 -0.01512 -0.06057 0.08014  194 ALA A O   
87   C CB  . ALA A 14  ? 0.46866 0.43466 0.42251 -0.01523 -0.07711 0.07717  194 ALA A CB  
93   N N   . LEU A 15  ? 0.25531 0.20219 0.21317 -0.02748 -0.07580 0.08359  195 LEU A N   
94   C CA  . LEU A 15  ? 0.24687 0.19076 0.19938 -0.03042 -0.06444 0.08429  195 LEU A CA  
95   C C   . LEU A 15  ? 0.23057 0.15554 0.20889 -0.03025 -0.06759 0.08494  195 LEU A C   
96   O O   . LEU A 15  ? 0.33336 0.25338 0.32425 -0.02836 -0.05342 0.08269  195 LEU A O   
97   C CB  . LEU A 15  ? 0.35550 0.31069 0.27557 -0.03900 -0.06302 0.08120  195 LEU A CB  
98   C CG  . LEU A 15  ? 0.21813 0.19681 0.12404 -0.03577 -0.05263 0.07385  195 LEU A CG  
99   C CD1 . LEU A 15  ? 0.22401 0.21380 0.11468 -0.04215 -0.04879 0.06603  195 LEU A CD1 
100  C CD2 . LEU A 15  ? 0.35097 0.33162 0.25779 -0.03057 -0.04037 0.07619  195 LEU A CD2 
112  N N   . GLU A 16  ? 0.33282 0.24588 0.31939 -0.03241 -0.08639 0.08734  196 GLU A N   
113  C CA  . GLU A 16  ? 0.31043 0.20491 0.32225 -0.03113 -0.09280 0.08757  196 GLU A CA  
114  C C   . GLU A 16  ? 0.35778 0.24932 0.41890 -0.02161 -0.09369 0.08389  196 GLU A C   
115  O O   . GLU A 16  ? 0.29298 0.17616 0.38399 -0.01765 -0.09182 0.07972  196 GLU A O   
116  C CB  . GLU A 16  ? 0.29488 0.18080 0.28908 -0.03920 -0.11151 0.08737  196 GLU A CB  
117  C CG  . GLU A 16  ? 0.31272 0.20628 0.26121 -0.05088 -0.10827 0.08676  196 GLU A CG  
118  C CD  . GLU A 16  ? 0.52993 0.40886 0.46185 -0.06154 -0.12252 0.08534  196 GLU A CD  
119  O OE1 . GLU A 16  ? 0.64005 0.50210 0.59330 -0.05899 -0.13785 0.08610  196 GLU A OE1 
120  O OE2 . GLU A 16  ? 0.45316 0.33840 0.35443 -0.07230 -0.11712 0.08201  196 GLU A OE2 
127  N N   . TYR A 17  ? 0.29891 0.20007 0.36975 -0.01805 -0.09512 0.08282  197 TYR A N   
128  C CA  . TYR A 17  ? 0.37597 0.27949 0.49221 -0.01114 -0.09374 0.07732  197 TYR A CA  
129  C C   . TYR A 17  ? 0.23787 0.14935 0.36320 -0.00745 -0.07472 0.07493  197 TYR A C   
130  O O   . TYR A 17  ? 0.22706 0.13867 0.38153 -0.00487 -0.05940 0.06927  197 TYR A O   
131  C CB  . TYR A 17  ? 0.23457 0.14047 0.35588 -0.01306 -0.11314 0.07605  197 TYR A CB  
132  C CG  . TYR A 17  ? 0.23321 0.14437 0.40115 -0.00810 -0.11395 0.07065  197 TYR A CG  
133  C CD1 . TYR A 17  ? 0.31918 0.23069 0.52737 -0.00367 -0.11013 0.06540  197 TYR A CD1 
134  C CD2 . TYR A 17  ? 0.29451 0.21099 0.46687 -0.00848 -0.11791 0.07000  197 TYR A CD2 
135  C CE1 . TYR A 17  ? 0.40525 0.32543 0.65928 -0.00048 -0.11047 0.05966  197 TYR A CE1 
136  C CE2 . TYR A 17  ? 0.32777 0.25003 0.54273 -0.00597 -0.11909 0.06545  197 TYR A CE2 
137  C CZ  . TYR A 17  ? 0.32306 0.24867 0.58010 -0.00228 -0.11535 0.06027  197 TYR A CZ  
138  O OH  . TYR A 17  ? 0.34824 0.28261 0.65183 -0.00082 -0.11626 0.05496  197 TYR A OH  
148  N N   . ILE A 18  ? 0.23889 0.15830 0.33769 -0.00797 -0.07362 0.07662  198 ILE A N   
149  C CA  . ILE A 18  ? 0.31562 0.24002 0.42191 -0.00476 -0.05928 0.07338  198 ILE A CA  
150  C C   . ILE A 18  ? 0.20426 0.12933 0.30116 -0.00608 -0.03699 0.07090  198 ILE A C   
151  O O   . ILE A 18  ? 0.20449 0.12711 0.32206 -0.00610 -0.02229 0.06648  198 ILE A O   
152  C CB  . ILE A 18  ? 0.35416 0.28396 0.43338 -0.00362 -0.06547 0.07520  198 ILE A CB  
153  C CG1 . ILE A 18  ? 0.26952 0.19529 0.36010 -0.00403 -0.08550 0.07662  198 ILE A CG1 
154  C CG2 . ILE A 18  ? 0.36922 0.29965 0.44704 -0.00061 -0.05085 0.07276  198 ILE A CG2 
155  C CD1 . ILE A 18  ? 0.24076 0.17032 0.30256 -0.00374 -0.09208 0.07687  198 ILE A CD1 
167  N N   . VAL A 19  ? 0.20605 0.13381 0.26985 -0.00915 -0.03403 0.07345  199 VAL A N   
168  C CA  . VAL A 19  ? 0.26055 0.18744 0.30793 -0.01201 -0.01506 0.07224  199 VAL A CA  
169  C C   . VAL A 19  ? 0.24088 0.15877 0.31553 -0.01419 -0.00154 0.06711  199 VAL A C   
170  O O   . VAL A 19  ? 0.27134 0.18535 0.35373 -0.01625 0.01575  0.06301  199 VAL A O   
171  C CB  . VAL A 19  ? 0.31236 0.24536 0.32181 -0.01604 -0.01715 0.07589  199 VAL A CB  
172  C CG1 . VAL A 19  ? 0.30821 0.23610 0.30390 -0.02120 0.00025  0.07494  199 VAL A CG1 
173  C CG2 . VAL A 19  ? 0.23248 0.17781 0.21726 -0.01324 -0.02331 0.07775  199 VAL A CG2 
183  N N   . PRO A 20  ? 0.26921 0.18187 0.35709 -0.01461 -0.00815 0.06638  200 PRO A N   
184  C CA  . PRO A 20  ? 0.22409 0.12886 0.34286 -0.01506 0.00575  0.05900  200 PRO A CA  
185  C C   . PRO A 20  ? 0.27574 0.18310 0.44003 -0.01171 0.01107  0.05224  200 PRO A C   
186  O O   . PRO A 20  ? 0.29828 0.20329 0.48069 -0.01468 0.03201  0.04415  200 PRO A O   
187  C CB  . PRO A 20  ? 0.29292 0.18963 0.41809 -0.01392 -0.00936 0.06037  200 PRO A CB  
188  C CG  . PRO A 20  ? 0.22837 0.12833 0.33666 -0.01344 -0.03320 0.06801  200 PRO A CG  
189  C CD  . PRO A 20  ? 0.27944 0.19076 0.35417 -0.01546 -0.02854 0.07142  200 PRO A CD  
197  N N   A CYS A 21  ? 0.26119 0.17340 0.44338 -0.00729 -0.00667 0.05468  201 CYS A N   
198  N N   B CYS A 21  ? 0.26120 0.17342 0.44337 -0.00730 -0.00662 0.05467  201 CYS A N   
199  C CA  A CYS A 21  ? 0.22760 0.14423 0.45428 -0.00536 -0.00295 0.04830  201 CYS A CA  
200  C CA  B CYS A 21  ? 0.22781 0.14442 0.45471 -0.00536 -0.00286 0.04824  201 CYS A CA  
201  C C   A CYS A 21  ? 0.21332 0.13072 0.42914 -0.01069 0.01830  0.04525  201 CYS A C   
202  C C   B CYS A 21  ? 0.21328 0.13073 0.42935 -0.01066 0.01821  0.04524  201 CYS A C   
203  O O   A CYS A 21  ? 0.26792 0.18627 0.51336 -0.01421 0.03606  0.03631  201 CYS A O   
204  O O   B CYS A 21  ? 0.26707 0.18553 0.51295 -0.01416 0.03585  0.03632  201 CYS A O   
205  C CB  A CYS A 21  ? 0.25844 0.17820 0.49709 -0.00155 -0.02741 0.05299  201 CYS A CB  
206  C CB  B CYS A 21  ? 0.25739 0.17706 0.49713 -0.00146 -0.02759 0.05287  201 CYS A CB  
207  S SG  A CYS A 21  ? 0.24930 0.17286 0.53221 0.00341  -0.04846 0.04928  201 CYS A SG  
208  S SG  B CYS A 21  ? 0.20683 0.13581 0.51244 0.00195  -0.03311 0.04424  201 CYS A SG  
218  N N   . MET A 22  ? 0.25793 0.17405 0.43102 -0.01198 0.01648  0.05197  202 MET A N   
219  C CA  . MET A 22  ? 0.21949 0.13086 0.37646 -0.01728 0.03280  0.05064  202 MET A CA  
220  C C   . MET A 22  ? 0.23119 0.13485 0.37389 -0.02512 0.05596  0.04656  202 MET A C   
221  O O   . MET A 22  ? 0.28376 0.18118 0.43199 -0.03285 0.07444  0.04097  202 MET A O   
222  C CB  . MET A 22  ? 0.29405 0.20471 0.41081 -0.01451 0.02232  0.05832  202 MET A CB  
223  C CG  . MET A 22  ? 0.22034 0.13648 0.34616 -0.00839 0.00094  0.06134  202 MET A CG  
224  S SD  . MET A 22  ? 0.29389 0.20551 0.43875 -0.00952 0.00094  0.05890  202 MET A SD  
225  C CE  . MET A 22  ? 0.24824 0.14654 0.35999 -0.01546 0.02000  0.05899  202 MET A CE  
235  N N   . ASN A 23  ? 0.31274 0.21500 0.43414 -0.02536 0.05575  0.04901  203 ASN A N   
236  C CA  . ASN A 23  ? 0.32834 0.22082 0.43062 -0.03429 0.07723  0.04551  203 ASN A CA  
237  C C   . ASN A 23  ? 0.38734 0.27766 0.52971 -0.03796 0.09497  0.03352  203 ASN A C   
238  O O   . ASN A 23  ? 0.41185 0.29456 0.54313 -0.04730 0.11668  0.02683  203 ASN A O   
239  C CB  . ASN A 23  ? 0.25981 0.15147 0.32762 -0.03463 0.07150  0.05130  203 ASN A CB  
240  C CG  . ASN A 23  ? 0.36596 0.26171 0.39313 -0.03301 0.06011  0.06043  203 ASN A CG  
241  O OD1 . ASN A 23  ? 0.30491 0.19599 0.31638 -0.03484 0.06410  0.06218  203 ASN A OD1 
242  N ND2 . ASN A 23  ? 0.24646 0.15043 0.25682 -0.02997 0.04563  0.06556  203 ASN A ND2 
249  N N   . LYS A 24  ? 0.24438 0.14273 0.43185 -0.03016 0.08439  0.02922  204 LYS A N   
250  C CA  . LYS A 24  ? 0.26659 0.16608 0.50024 -0.03122 0.10012  0.01575  204 LYS A CA  
251  C C   . LYS A 24  ? 0.30231 0.21032 0.57681 -0.03369 0.10911  0.00730  204 LYS A C   
252  O O   . LYS A 24  ? 0.33143 0.24222 0.62681 -0.03928 0.13189  -0.00602 204 LYS A O   
253  C CB  . LYS A 24  ? 0.28780 0.18979 0.55264 -0.02084 0.08230  0.01467  204 LYS A CB  
254  C CG  . LYS A 24  ? 0.40144 0.29235 0.63227 -0.02140 0.07946  0.01906  204 LYS A CG  
255  C CD  . LYS A 24  ? 0.36629 0.25445 0.62592 -0.01192 0.05934  0.01855  204 LYS A CD  
256  C CE  . LYS A 24  ? 0.33251 0.20614 0.56162 -0.01446 0.06064  0.02028  204 LYS A CE  
257  N NZ  . LYS A 24  ? 0.28806 0.15402 0.51889 -0.02102 0.09049  0.00859  204 LYS A NZ  
271  N N   . HIS A 25  ? 0.30056 0.21545 0.58226 -0.02931 0.09115  0.01345  205 HIS A N   
272  C CA  . HIS A 25  ? 0.27447 0.19875 0.59738 -0.03181 0.09588  0.00603  205 HIS A CA  
273  C C   . HIS A 25  ? 0.26230 0.18173 0.55275 -0.03813 0.09697  0.01167  205 HIS A C   
274  O O   . HIS A 25  ? 0.29546 0.21994 0.60253 -0.04426 0.10868  0.00375  205 HIS A O   
275  C CB  . HIS A 25  ? 0.30495 0.24099 0.67344 -0.02078 0.07016  0.00690  205 HIS A CB  
276  C CG  . HIS A 25  ? 0.28651 0.22375 0.68238 -0.01198 0.06092  0.00354  205 HIS A CG  
277  N ND1 . HIS A 25  ? 0.37568 0.31845 0.81794 -0.01140 0.07741  -0.01121 205 HIS A ND1 
278  C CD2 . HIS A 25  ? 0.22108 0.15254 0.60309 -0.00403 0.03663  0.01250  205 HIS A CD2 
279  C CE1 . HIS A 25  ? 0.23226 0.17380 0.68588 -0.00173 0.06153  -0.01050 205 HIS A CE1 
280  N NE2 . HIS A 25  ? 0.22705 0.16129 0.64168 0.00167  0.03647  0.00426  205 HIS A NE2 
288  N N   . GLY A 26  ? 0.25170 0.16205 0.49499 -0.03588 0.08409  0.02417  206 GLY A N   
289  C CA  . GLY A 26  ? 0.32211 0.22501 0.53795 -0.03918 0.08056  0.03000  206 GLY A CA  
290  C C   . GLY A 26  ? 0.29797 0.20829 0.53712 -0.03322 0.06050  0.03251  206 GLY A C   
291  O O   . GLY A 26  ? 0.24306 0.14548 0.46266 -0.03597 0.05754  0.03616  206 GLY A O   
295  N N   . ILE A 27  ? 0.22369 0.14609 0.50234 -0.02578 0.04558  0.03078  207 ILE A N   
296  C CA  . ILE A 27  ? 0.24908 0.17714 0.54903 -0.02117 0.02384  0.03371  207 ILE A CA  
297  C C   . ILE A 27  ? 0.22791 0.15965 0.53216 -0.01197 0.00024  0.03906  207 ILE A C   
298  O O   . ILE A 27  ? 0.20613 0.14063 0.52877 -0.00907 0.00142  0.03580  207 ILE A O   
299  C CB  . ILE A 27  ? 0.21827 0.15684 0.57445 -0.02584 0.03010  0.02382  207 ILE A CB  
300  C CG1 . ILE A 27  ? 0.23891 0.17288 0.58219 -0.03766 0.05402  0.01804  207 ILE A CG1 
301  C CG2 . ILE A 27  ? 0.26605 0.20982 0.64207 -0.02165 0.00471  0.02775  207 ILE A CG2 
302  C CD1 . ILE A 27  ? 0.33686 0.28682 0.72990 -0.04266 0.06769  0.00434  207 ILE A CD1 
314  N N   . CYS A 28  ? 0.20514 0.13426 0.48968 -0.00851 -0.02105 0.04682  208 CYS A N   
315  C CA  . CYS A 28  ? 0.23671 0.16645 0.51598 -0.00323 -0.04446 0.05237  208 CYS A CA  
316  C C   . CYS A 28  ? 0.21362 0.14668 0.49818 -0.00313 -0.06567 0.05456  208 CYS A C   
317  O O   . CYS A 28  ? 0.21170 0.13929 0.47806 -0.00486 -0.06558 0.05672  208 CYS A O   
318  C CB  . CYS A 28  ? 0.24888 0.17345 0.47614 -0.00211 -0.04599 0.05901  208 CYS A CB  
319  S SG  . CYS A 28  ? 0.25427 0.17916 0.46469 -0.00061 -0.07188 0.06430  208 CYS A SG  
325  N N   . VAL A 29  ? 0.24371 0.18331 0.55022 -0.00226 -0.08444 0.05391  209 VAL A N   
326  C CA  . VAL A 29  ? 0.37398 0.31486 0.68547 -0.00505 -0.10614 0.05577  209 VAL A CA  
327  C C   . VAL A 29  ? 0.31279 0.24798 0.59258 -0.00760 -0.12526 0.05991  209 VAL A C   
328  O O   . VAL A 29  ? 0.34321 0.27794 0.62764 -0.00704 -0.12918 0.05924  209 VAL A O   
329  C CB  . VAL A 29  ? 0.23632 0.18772 0.60758 -0.00578 -0.11247 0.05020  209 VAL A CB  
330  C CG1 . VAL A 29  ? 0.23501 0.18398 0.60768 -0.01103 -0.13815 0.05299  209 VAL A CG1 
331  C CG2 . VAL A 29  ? 0.20700 0.16272 0.60791 -0.00620 -0.09132 0.04469  209 VAL A CG2 
341  N N   . VAL A 30  ? 0.25739 0.18571 0.50383 -0.01148 -0.13605 0.06328  210 VAL A N   
342  C CA  . VAL A 30  ? 0.24806 0.16736 0.46004 -0.01720 -0.15179 0.06600  210 VAL A CA  
343  C C   . VAL A 30  ? 0.31730 0.22943 0.53330 -0.02423 -0.17027 0.06612  210 VAL A C   
344  O O   . VAL A 30  ? 0.32071 0.22927 0.51940 -0.02528 -0.17006 0.06680  210 VAL A O   
345  C CB  . VAL A 30  ? 0.35906 0.27477 0.52218 -0.01663 -0.14395 0.06858  210 VAL A CB  
346  C CG1 . VAL A 30  ? 0.34813 0.25351 0.47712 -0.02501 -0.15827 0.07011  210 VAL A CG1 
347  C CG2 . VAL A 30  ? 0.26626 0.18664 0.42470 -0.01111 -0.12710 0.06944  210 VAL A CG2 
357  N N   . ASP A 31  ? 0.33763 0.24439 0.57514 -0.02927 -0.18690 0.06547  211 ASP A N   
358  C CA  . ASP A 31  ? 0.32350 0.21804 0.56584 -0.03746 -0.20572 0.06626  211 ASP A CA  
359  C C   . ASP A 31  ? 0.31614 0.19036 0.50805 -0.04551 -0.21590 0.06956  211 ASP A C   
360  O O   . ASP A 31  ? 0.30670 0.17524 0.47269 -0.04804 -0.21497 0.07064  211 ASP A O   
361  C CB  . ASP A 31  ? 0.41329 0.30782 0.69669 -0.03561 -0.21513 0.06449  211 ASP A CB  
362  C CG  . ASP A 31  ? 0.39850 0.30945 0.73369 -0.02966 -0.20549 0.06045  211 ASP A CG  
363  O OD1 . ASP A 31  ? 0.32459 0.24133 0.65990 -0.02915 -0.19849 0.06084  211 ASP A OD1 
364  O OD2 . ASP A 31  ? 0.43111 0.34804 0.80752 -0.02579 -0.20468 0.05630  211 ASP A OD2 
369  N N   . ASP A 32  ? 0.33984 0.20248 0.51723 -0.04961 -0.22420 0.07141  212 ASP A N   
370  C CA  . ASP A 32  ? 0.34393 0.18595 0.47380 -0.05784 -0.23124 0.07465  212 ASP A CA  
371  C C   . ASP A 32  ? 0.39381 0.23559 0.48813 -0.05982 -0.22039 0.07391  212 ASP A C   
372  O O   . ASP A 32  ? 0.34914 0.18158 0.41345 -0.06491 -0.22045 0.07571  212 ASP A O   
373  C CB  . ASP A 32  ? 0.42656 0.25371 0.55029 -0.06246 -0.24417 0.07768  212 ASP A CB  
374  C CG  . ASP A 32  ? 0.44295 0.26740 0.60213 -0.06082 -0.25758 0.07861  212 ASP A CG  
375  O OD1 . ASP A 32  ? 0.55190 0.36745 0.70700 -0.06369 -0.26487 0.08117  212 ASP A OD1 
376  O OD2 . ASP A 32  ? 0.47175 0.30202 0.66370 -0.05673 -0.26154 0.07677  212 ASP A OD2 
381  N N   . PHE A 33  ? 0.31617 0.17310 0.41155 -0.05213 -0.20743 0.07137  213 PHE A N   
382  C CA  . PHE A 33  ? 0.30543 0.17173 0.37024 -0.04681 -0.19182 0.07012  213 PHE A CA  
383  C C   . PHE A 33  ? 0.43763 0.29169 0.45744 -0.05391 -0.19392 0.07003  213 PHE A C   
384  O O   . PHE A 33  ? 0.36740 0.22495 0.35992 -0.05584 -0.18690 0.06954  213 PHE A O   
385  C CB  . PHE A 33  ? 0.39766 0.27767 0.47485 -0.03606 -0.17870 0.06828  213 PHE A CB  
386  C CG  . PHE A 33  ? 0.44184 0.32924 0.48833 -0.02961 -0.16462 0.06696  213 PHE A CG  
387  C CD1 . PHE A 33  ? 0.32897 0.22349 0.35926 -0.02953 -0.15771 0.06741  213 PHE A CD1 
388  C CD2 . PHE A 33  ? 0.27924 0.16592 0.31371 -0.02359 -0.15943 0.06501  213 PHE A CD2 
389  C CE1 . PHE A 33  ? 0.36668 0.27140 0.37183 -0.02396 -0.14600 0.06559  213 PHE A CE1 
390  C CE2 . PHE A 33  ? 0.46341 0.35786 0.47255 -0.01659 -0.14847 0.06296  213 PHE A CE2 
391  C CZ  . PHE A 33  ? 0.26795 0.17354 0.26377 -0.01694 -0.14181 0.06306  213 PHE A CZ  
401  N N   . LEU A 34  ? 0.45518 0.29595 0.46679 -0.05857 -0.20268 0.07013  214 LEU A N   
402  C CA  . LEU A 34  ? 0.45705 0.28876 0.42658 -0.06465 -0.20217 0.06864  214 LEU A CA  
403  C C   . LEU A 34  ? 0.47947 0.28617 0.43337 -0.07772 -0.21648 0.07348  214 LEU A C   
404  O O   . LEU A 34  ? 0.52025 0.32075 0.43713 -0.08527 -0.21413 0.07219  214 LEU A O   
405  C CB  . LEU A 34  ? 0.45155 0.28586 0.41398 -0.05874 -0.19889 0.06428  214 LEU A CB  
406  C CG  . LEU A 34  ? 0.36167 0.21554 0.32600 -0.04518 -0.18412 0.06039  214 LEU A CG  
407  C CD1 . LEU A 34  ? 0.43878 0.28704 0.39465 -0.03919 -0.18453 0.05683  214 LEU A CD1 
408  C CD2 . LEU A 34  ? 0.43807 0.30571 0.37546 -0.04459 -0.17281 0.05688  214 LEU A CD2 
420  N N   . GLY A 35  ? 0.49041 0.28348 0.47155 -0.08075 -0.23072 0.07871  215 GLY A N   
421  C CA  . GLY A 35  ? 0.51930 0.28761 0.48582 -0.09117 -0.24548 0.08512  215 GLY A CA  
422  C C   . GLY A 35  ? 0.64042 0.40217 0.61329 -0.09103 -0.25371 0.08625  215 GLY A C   
423  O O   . GLY A 35  ? 0.54093 0.30924 0.52039 -0.08600 -0.24900 0.08249  215 GLY A O   
427  N N   . LYS A 36  ? 0.61977 0.29503 0.55145 -0.00995 -0.33844 0.04746  216 LYS A N   
428  C CA  . LYS A 36  ? 0.62680 0.30614 0.55963 -0.00832 -0.34004 0.04537  216 LYS A CA  
429  C C   . LYS A 36  ? 0.66109 0.34175 0.58668 -0.00913 -0.33953 0.04327  216 LYS A C   
430  O O   . LYS A 36  ? 0.67983 0.36202 0.60974 -0.00783 -0.33914 0.03878  216 LYS A O   
431  C CB  . LYS A 36  ? 0.63182 0.31224 0.56097 -0.00793 -0.34469 0.04974  216 LYS A CB  
432  C CG  . LYS A 36  ? 0.63143 0.31648 0.56547 -0.00590 -0.34703 0.04752  216 LYS A CG  
433  C CD  . LYS A 36  ? 0.65042 0.33733 0.58185 -0.00483 -0.35138 0.05180  216 LYS A CD  
440  N N   . GLU A 37  ? 0.69339 0.37418 0.60786 -0.01101 -0.33975 0.04676  217 GLU A N   
441  C CA  . GLU A 37  ? 0.71340 0.39740 0.61897 -0.01051 -0.33931 0.04451  217 GLU A CA  
442  C C   . GLU A 37  ? 0.64476 0.32750 0.55511 -0.00947 -0.33528 0.03873  217 GLU A C   
443  O O   . GLU A 37  ? 0.70188 0.38487 0.61409 -0.00764 -0.33589 0.03382  217 GLU A O   
444  C CB  . GLU A 37  ? 0.64000 0.32745 0.53333 -0.01240 -0.33932 0.05025  217 GLU A CB  
445  C CG  . GLU A 37  ? 0.64261 0.33591 0.52544 -0.01086 -0.33804 0.04755  217 GLU A CG  
450  N N   . THR A 38  ? 0.61932 0.30048 0.53186 -0.01064 -0.33159 0.03939  218 THR A N   
451  C CA  . THR A 38  ? 0.60133 0.28225 0.51754 -0.00928 -0.32742 0.03429  218 THR A CA  
452  C C   . THR A 38  ? 0.59215 0.27231 0.52049 -0.00726 -0.32690 0.02955  218 THR A C   
453  O O   . THR A 38  ? 0.62013 0.30039 0.55015 -0.00565 -0.32546 0.02513  218 THR A O   
454  C CB  . THR A 38  ? 0.59588 0.27563 0.51401 -0.01084 -0.32417 0.03594  218 THR A CB  
455  O OG1 . THR A 38  ? 0.60524 0.28702 0.51279 -0.01353 -0.32508 0.04177  218 THR A OG1 
456  C CG2 . THR A 38  ? 0.58939 0.26997 0.51091 -0.00889 -0.31961 0.03071  218 THR A CG2 
464  N N   . GLY A 39  ? 0.59047 0.27085 0.52740 -0.00713 -0.32815 0.03083  219 GLY A N   
465  C CA  . GLY A 39  ? 0.58272 0.26567 0.53142 -0.00535 -0.32786 0.02779  219 GLY A CA  
466  C C   . GLY A 39  ? 0.58815 0.27098 0.53560 -0.00524 -0.33166 0.02629  219 GLY A C   
467  O O   . GLY A 39  ? 0.65630 0.33985 0.61090 -0.00450 -0.33118 0.02315  219 GLY A O   
471  N N   . GLN A 40  ? 0.60044 0.28262 0.53887 -0.00596 -0.33594 0.02860  220 GLN A N   
472  C CA  . GLN A 40  ? 0.63761 0.31957 0.57367 -0.00553 -0.34046 0.02643  220 GLN A CA  
473  C C   . GLN A 40  ? 0.68490 0.36445 0.61469 -0.00443 -0.33952 0.02196  220 GLN A C   
474  O O   . GLN A 40  ? 0.66651 0.34405 0.60043 -0.00379 -0.34209 0.01849  220 GLN A O   
475  C CB  . GLN A 40  ? 0.62132 0.30492 0.54765 -0.00579 -0.34489 0.02943  220 GLN A CB  
478  N N   . GLN A 41  ? 0.60890 0.28889 0.52871 -0.00411 -0.33628 0.02224  221 GLN A N   
479  C CA  . GLN A 41  ? 0.66712 0.34612 0.58040 -0.00210 -0.33484 0.01763  221 GLN A CA  
480  C C   . GLN A 41  ? 0.64846 0.32463 0.57309 -0.00141 -0.33200 0.01437  221 GLN A C   
481  O O   . GLN A 41  ? 0.59895 0.27210 0.52350 0.00030  -0.33360 0.01006  221 GLN A O   
482  C CB  . GLN A 41  ? 0.71171 0.39442 0.61315 -0.00190 -0.33128 0.01930  221 GLN A CB  
483  C CG  . GLN A 41  ? 0.73662 0.42483 0.62391 -0.00169 -0.33397 0.02193  221 GLN A CG  
484  C CD  . GLN A 41  ? 0.96936 0.66089 0.85379 -0.00454 -0.33257 0.02936  221 GLN A CD  
485  O OE1 . GLN A 41  ? 0.96550 0.65411 0.85784 -0.00667 -0.33351 0.03303  221 GLN A OE1 
486  N NE2 . GLN A 41  ? 1.06339 0.76154 0.93653 -0.00451 -0.33057 0.03185  221 GLN A NE2 
495  N N   . ILE A 42  ? 0.59722 0.27478 0.53146 -0.00238 -0.32804 0.01618  222 ILE A N   
496  C CA  . ILE A 42  ? 0.60553 0.28322 0.55087 -0.00147 -0.32492 0.01337  222 ILE A CA  
497  C C   . ILE A 42  ? 0.64133 0.31852 0.59726 -0.00198 -0.32896 0.01266  222 ILE A C   
498  O O   . ILE A 42  ? 0.60516 0.28039 0.56609 -0.00126 -0.32924 0.00986  222 ILE A O   
499  C CB  . ILE A 42  ? 0.60079 0.28258 0.55390 -0.00173 -0.32009 0.01488  222 ILE A CB  
500  C CG1 . ILE A 42  ? 0.56306 0.24448 0.50672 -0.00184 -0.31684 0.01579  222 ILE A CG1 
501  C CG2 . ILE A 42  ? 0.60655 0.29213 0.57196 -0.00039 -0.31671 0.01218  222 ILE A CG2 
502  C CD1 . ILE A 42  ? 0.55597 0.23985 0.50547 -0.00224 -0.31377 0.01735  222 ILE A CD1 
514  N N   . GLY A 43  ? 0.57848 0.25777 0.53849 -0.00338 -0.33250 0.01572  223 GLY A N   
515  C CA  . GLY A 43  ? 0.69487 0.37489 0.66521 -0.00443 -0.33709 0.01607  223 GLY A CA  
516  C C   . GLY A 43  ? 0.65139 0.32476 0.61564 -0.00413 -0.34258 0.01296  223 GLY A C   
517  O O   . GLY A 43  ? 0.73344 0.40477 0.70665 -0.00487 -0.34555 0.01199  223 GLY A O   
521  N N   . ASP A 44  ? 0.70096 0.37177 0.64992 -0.00286 -0.34432 0.01146  224 ASP A N   
522  C CA  . ASP A 44  ? 0.71145 0.37707 0.65254 -0.00124 -0.34940 0.00710  224 ASP A CA  
523  C C   . ASP A 44  ? 0.61067 0.27166 0.55180 0.00081  -0.34733 0.00312  224 ASP A C   
524  O O   . ASP A 44  ? 0.67378 0.32912 0.61804 0.00139  -0.35222 0.00034  224 ASP A O   
525  C CB  . ASP A 44  ? 0.70523 0.37277 0.62885 0.00055  -0.35037 0.00586  224 ASP A CB  
526  C CG  . ASP A 44  ? 0.73706 0.40764 0.65940 -0.00070 -0.35530 0.00832  224 ASP A CG  
527  O OD1 . ASP A 44  ? 0.87552 0.54642 0.81033 -0.00288 -0.35829 0.01067  224 ASP A OD1 
528  O OD2 . ASP A 44  ? 0.79757 0.47166 0.70635 0.00068  -0.35620 0.00814  224 ASP A OD2 
533  N N   . GLU A 45  ? 0.60166 0.26476 0.53928 0.00203  -0.34058 0.00290  225 GLU A N   
534  C CA  . GLU A 45  ? 0.61776 0.27734 0.55505 0.00450  -0.33824 -0.00089 225 GLU A CA  
535  C C   . GLU A 45  ? 0.63944 0.29742 0.59402 0.00279  -0.33902 0.00012  225 GLU A C   
536  O O   . GLU A 45  ? 0.63649 0.28852 0.59313 0.00422  -0.34181 -0.00265 225 GLU A O   
537  C CB  . GLU A 45  ? 0.58936 0.25329 0.52025 0.00585  -0.33080 -0.00084 225 GLU A CB  
538  C CG  . GLU A 45  ? 0.59831 0.26592 0.51235 0.00708  -0.33011 -0.00097 225 GLU A CG  
539  C CD  . GLU A 45  ? 0.59071 0.26341 0.49959 0.00766  -0.32342 0.00017  225 GLU A CD  
540  O OE1 . GLU A 45  ? 0.65375 0.32647 0.57156 0.00768  -0.31923 0.00008  225 GLU A OE1 
541  O OE2 . GLU A 45  ? 0.59732 0.27521 0.49349 0.00801  -0.32253 0.00139  225 GLU A OE2 
548  N N   . VAL A 46  ? 0.66217 0.32659 0.62935 -0.00012 -0.33681 0.00420  226 VAL A N   
549  C CA  . VAL A 46  ? 0.70787 0.37543 0.69239 -0.00222 -0.33715 0.00583  226 VAL A CA  
550  C C   . VAL A 46  ? 0.59953 0.26167 0.59022 -0.00418 -0.34575 0.00678  226 VAL A C   
551  O O   . VAL A 46  ? 0.60112 0.26029 0.60119 -0.00518 -0.34842 0.00670  226 VAL A O   
552  C CB  . VAL A 46  ? 0.55851 0.23780 0.55382 -0.00372 -0.33268 0.00981  226 VAL A CB  
553  C CG1 . VAL A 46  ? 0.55100 0.23804 0.56476 -0.00576 -0.33335 0.01279  226 VAL A CG1 
554  C CG2 . VAL A 46  ? 0.62648 0.31059 0.61767 -0.00154 -0.32473 0.00853  226 VAL A CG2 
564  N N   . ARG A 47  ? 0.61133 0.27250 0.59740 -0.00500 -0.35067 0.00794  227 ARG A N   
565  C CA  . ARG A 47  ? 0.69093 0.34755 0.68271 -0.00694 -0.35949 0.00870  227 ARG A CA  
566  C C   . ARG A 47  ? 0.61625 0.26194 0.59849 -0.00395 -0.36430 0.00356  227 ARG A C   
567  O O   . ARG A 47  ? 0.62422 0.26445 0.61430 -0.00535 -0.37147 0.00401  227 ARG A O   
568  C CB  . ARG A 47  ? 0.68169 0.34160 0.66992 -0.00814 -0.36327 0.01047  227 ARG A CB  
569  C CG  . ARG A 47  ? 0.68723 0.35772 0.68990 -0.01121 -0.36205 0.01631  227 ARG A CG  
570  C CD  . ARG A 47  ? 0.74937 0.42315 0.74740 -0.01173 -0.36572 0.01793  227 ARG A CD  
571  N NE  . ARG A 47  ? 0.90033 0.57259 0.88128 -0.00903 -0.36289 0.01564  227 ARG A NE  
572  C CZ  . ARG A 47  ? 0.91729 0.59510 0.89560 -0.00836 -0.35773 0.01815  227 ARG A CZ  
573  N NH1 . ARG A 47  ? 0.70533 0.39102 0.69571 -0.00907 -0.35424 0.02197  227 ARG A NH1 
574  N NH2 . ARG A 47  ? 0.84026 0.51655 0.80345 -0.00664 -0.35622 0.01699  227 ARG A NH2 
588  N N   . ALA A 48  ? 0.61930 0.26272 0.58476 0.00031  -0.36079 -0.00118 228 ALA A N   
589  C CA  . ALA A 48  ? 0.63070 0.26571 0.58630 0.00441  -0.36425 -0.00701 228 ALA A CA  
590  C C   . ALA A 48  ? 0.67986 0.31062 0.64491 0.00509  -0.36326 -0.00666 228 ALA A C   
591  O O   . ALA A 48  ? 0.63400 0.25676 0.60066 0.00658  -0.36975 -0.00864 228 ALA A O   
592  C CB  . ALA A 48  ? 0.65203 0.28919 0.58777 0.00876  -0.35971 -0.01183 228 ALA A CB  
598  N N   . LEU A 49  ? 0.60734 0.24385 0.57875 0.00414  -0.35552 -0.00438 229 LEU A N   
599  C CA  . LEU A 49  ? 0.59873 0.23594 0.58118 0.00388  -0.35349 -0.00377 229 LEU A CA  
600  C C   . LEU A 49  ? 0.59933 0.23969 0.60032 -0.00099 -0.35891 0.00104  229 LEU A C   
601  O O   . LEU A 49  ? 0.61708 0.25648 0.62389 -0.00070 -0.36173 0.00099  229 LEU A O   
602  C CB  . LEU A 49  ? 0.61128 0.26104 0.59857 0.00281  -0.34301 -0.00286 229 LEU A CB  
603  C CG  . LEU A 49  ? 0.57676 0.22516 0.54848 0.00699  -0.33702 -0.00674 229 LEU A CG  
604  C CD1 . LEU A 49  ? 0.55955 0.21956 0.53788 0.00513  -0.32891 -0.00501 229 LEU A CD1 
605  C CD2 . LEU A 49  ? 0.57952 0.22495 0.54374 0.01184  -0.33569 -0.01127 229 LEU A CD2 
617  N N   . HIS A 50  ? 0.59724 0.24105 0.60798 -0.00562 -0.36111 0.00569  230 HIS A N   
618  C CA  . HIS A 50  ? 0.59838 0.24552 0.62792 -0.01097 -0.36693 0.01138  230 HIS A CA  
619  C C   . HIS A 50  ? 0.61806 0.25290 0.64532 -0.01031 -0.37818 0.01077  230 HIS A C   
620  O O   . HIS A 50  ? 0.62084 0.25662 0.66082 -0.01292 -0.38268 0.01391  230 HIS A O   
621  C CB  . HIS A 50  ? 0.59320 0.24893 0.63119 -0.01489 -0.36667 0.01612  230 HIS A CB  
622  C CG  . HIS A 50  ? 0.59028 0.25433 0.64993 -0.02065 -0.37054 0.02326  230 HIS A CG  
623  N ND1 . HIS A 50  ? 0.58561 0.26305 0.65446 -0.02317 -0.36978 0.02856  230 HIS A ND1 
624  C CD2 . HIS A 50  ? 0.59188 0.25408 0.66627 -0.02425 -0.37525 0.02685  230 HIS A CD2 
625  C CE1 . HIS A 50  ? 0.58393 0.26902 0.67230 -0.02791 -0.37333 0.03539  230 HIS A CE1 
626  N NE2 . HIS A 50  ? 0.73200 0.40792 0.82470 -0.02929 -0.37690 0.03477  230 HIS A NE2 
634  N N   . ASP A 51  ? 0.63168 0.25876 0.64294 -0.00705 -0.38226 0.00639  231 ASP A N   
635  C CA  . ASP A 51  ? 0.65104 0.27002 0.65946 -0.00663 -0.39279 0.00415  231 ASP A CA  
636  C C   . ASP A 51  ? 0.65997 0.26915 0.66438 -0.00240 -0.39695 0.00046  231 ASP A C   
637  O O   . ASP A 51  ? 0.79545 0.39837 0.80520 -0.00360 -0.40675 0.00059  231 ASP A O   
638  C CB  . ASP A 51  ? 0.66171 0.28073 0.65230 -0.00403 -0.39345 -0.00170 231 ASP A CB  
639  C CG  . ASP A 51  ? 0.97929 0.59143 0.96736 -0.00419 -0.40436 -0.00521 231 ASP A CG  
640  O OD1 . ASP A 51  ? 1.14416 0.75823 1.14637 -0.00953 -0.41063 -0.00021 231 ASP A OD1 
641  O OD2 . ASP A 51  ? 0.91335 0.51883 0.88527 0.00104  -0.40670 -0.01336 231 ASP A OD2 
646  N N   . THR A 52  ? 0.53357 0.34372 0.64539 -0.00008 -0.20532 -0.10236 232 THR A N   
647  C CA  . THR A 52  ? 0.59038 0.38791 0.69685 0.00320  -0.19836 -0.10928 232 THR A CA  
648  C C   . THR A 52  ? 0.41928 0.21663 0.55326 0.00324  -0.18644 -0.10169 232 THR A C   
649  O O   . THR A 52  ? 0.42499 0.21215 0.55353 0.00799  -0.17794 -0.10392 232 THR A O   
650  C CB  . THR A 52  ? 0.49927 0.29424 0.57041 0.00884  -0.19491 -0.11378 232 THR A CB  
651  O OG1 . THR A 52  ? 0.54114 0.34681 0.60984 0.01008  -0.18890 -0.10391 232 THR A OG1 
652  C CG2 . THR A 52  ? 0.48993 0.28463 0.53091 0.00761  -0.20425 -0.12095 232 THR A CG2 
660  N N   . GLY A 53  ? 0.42827 0.23683 0.59072 -0.00141 -0.18471 -0.09243 233 GLY A N   
661  C CA  . GLY A 53  ? 0.44217 0.25126 0.63000 -0.00299 -0.17220 -0.08431 233 GLY A CA  
662  C C   . GLY A 53  ? 0.40283 0.21251 0.58206 0.00205  -0.15964 -0.07684 233 GLY A C   
663  O O   . GLY A 53  ? 0.40122 0.20217 0.58667 0.00425  -0.14904 -0.07352 233 GLY A O   
667  N N   . LYS A 54  ? 0.45332 0.27224 0.61733 0.00421  -0.16058 -0.07351 234 LYS A N   
668  C CA  . LYS A 54  ? 0.34421 0.16492 0.50040 0.00912  -0.14901 -0.06592 234 LYS A CA  
669  C C   . LYS A 54  ? 0.37545 0.20904 0.55605 0.00551  -0.13857 -0.05231 234 LYS A C   
670  O O   . LYS A 54  ? 0.34840 0.18304 0.52643 0.00964  -0.12654 -0.04384 234 LYS A O   
671  C CB  . LYS A 54  ? 0.33935 0.16336 0.46589 0.01218  -0.15441 -0.06900 234 LYS A CB  
672  C CG  . LYS A 54  ? 0.49360 0.30817 0.59051 0.01523  -0.16341 -0.08274 234 LYS A CG  
673  C CD  . LYS A 54  ? 0.46083 0.26201 0.54755 0.02378  -0.15598 -0.08910 234 LYS A CD  
674  C CE  . LYS A 54  ? 0.40211 0.19877 0.45365 0.02777  -0.16214 -0.10314 234 LYS A CE  
675  N NZ  . LYS A 54  ? 0.53864 0.32101 0.58716 0.03426  -0.15927 -0.11343 234 LYS A NZ  
689  N N   . PHE A 55  ? 0.34658 0.19083 0.55016 -0.00110 -0.14237 -0.05009 235 PHE A N   
690  C CA  . PHE A 55  ? 0.29448 0.15342 0.51978 -0.00457 -0.13290 -0.03901 235 PHE A CA  
691  C C   . PHE A 55  ? 0.29889 0.15518 0.54653 -0.00785 -0.12144 -0.03335 235 PHE A C   
692  O O   . PHE A 55  ? 0.34362 0.19092 0.60053 -0.01050 -0.12524 -0.03889 235 PHE A O   
693  C CB  . PHE A 55  ? 0.33558 0.20805 0.57520 -0.00826 -0.14228 -0.04005 235 PHE A CB  
694  C CG  . PHE A 55  ? 0.34446 0.21916 0.56083 -0.00556 -0.15303 -0.04306 235 PHE A CG  
695  C CD1 . PHE A 55  ? 0.39184 0.26100 0.57947 -0.00180 -0.15142 -0.04309 235 PHE A CD1 
696  C CD2 . PHE A 55  ? 0.35887 0.23997 0.58104 -0.00634 -0.16445 -0.04535 235 PHE A CD2 
697  C CE1 . PHE A 55  ? 0.33013 0.20088 0.49377 -0.00074 -0.16077 -0.04529 235 PHE A CE1 
698  C CE2 . PHE A 55  ? 0.42032 0.30107 0.61802 -0.00387 -0.17331 -0.04632 235 PHE A CE2 
699  C CZ  . PHE A 55  ? 0.29260 0.16873 0.46024 -0.00184 -0.17114 -0.04605 235 PHE A CZ  
709  N N   . THR A 56  ? 0.37955 0.24294 0.63407 -0.00803 -0.10735 -0.02196 236 THR A N   
710  C CA  . THR A 56  ? 0.31972 0.18136 0.59299 -0.01188 -0.09517 -0.01434 236 THR A CA  
711  C C   . THR A 56  ? 0.26944 0.14933 0.56184 -0.01627 -0.08636 -0.00555 236 THR A C   
712  O O   . THR A 56  ? 0.33276 0.22489 0.62130 -0.01497 -0.08813 -0.00441 236 THR A O   
713  C CB  . THR A 56  ? 0.29729 0.14565 0.55479 -0.00603 -0.08464 -0.00809 236 THR A CB  
714  O OG1 . THR A 56  ? 0.28870 0.14451 0.53018 -0.00026 -0.07848 -0.00114 236 THR A OG1 
715  C CG2 . THR A 56  ? 0.36015 0.19001 0.60109 -0.00078 -0.09257 -0.01828 236 THR A CG2 
723  N N   . ASP A 57  ? 0.27481 0.15544 0.58712 -0.02160 -0.07650 0.00040  237 ASP A N   
724  C CA  . ASP A 57  ? 0.26829 0.16629 0.60114 -0.02615 -0.06740 0.00716  237 ASP A CA  
725  C C   . ASP A 57  ? 0.24545 0.15206 0.56504 -0.02254 -0.05796 0.01593  237 ASP A C   
726  O O   . ASP A 57  ? 0.24457 0.14282 0.54642 -0.01855 -0.04999 0.02311  237 ASP A O   
727  C CB  . ASP A 57  ? 0.36439 0.25857 0.71482 -0.03243 -0.05627 0.01326  237 ASP A CB  
728  C CG  . ASP A 57  ? 0.34185 0.23198 0.71171 -0.03786 -0.06462 0.00493  237 ASP A CG  
729  O OD1 . ASP A 57  ? 0.42269 0.31688 0.79580 -0.03662 -0.07868 -0.00495 237 ASP A OD1 
730  O OD2 . ASP A 57  ? 0.30635 0.18855 0.68715 -0.04355 -0.05732 0.00870  237 ASP A OD2 
735  N N   . GLY A 58  ? 0.28810 0.21115 0.61622 -0.02323 -0.05907 0.01537  238 GLY A N   
736  C CA  . GLY A 58  ? 0.32613 0.25864 0.64451 -0.02111 -0.04944 0.02350  238 GLY A CA  
737  C C   . GLY A 58  ? 0.28805 0.22292 0.61126 -0.02376 -0.03157 0.03520  238 GLY A C   
738  O O   . GLY A 58  ? 0.27329 0.21197 0.61726 -0.02929 -0.02559 0.03632  238 GLY A O   
742  N N   . GLN A 59  ? 0.30397 0.23663 0.60656 -0.01961 -0.02302 0.04430  239 GLN A N   
743  C CA  . GLN A 59  ? 0.35875 0.29153 0.65928 -0.02105 -0.00703 0.05663  239 GLN A CA  
744  C C   . GLN A 59  ? 0.27563 0.22595 0.57490 -0.02209 0.00422  0.06363  239 GLN A C   
745  O O   . GLN A 59  ? 0.22831 0.18868 0.52649 -0.02098 -0.00035 0.05946  239 GLN A O   
746  C CB  . GLN A 59  ? 0.23604 0.15360 0.51242 -0.01399 -0.00549 0.06262  239 GLN A CB  
747  C CG  . GLN A 59  ? 0.24869 0.14742 0.52512 -0.01288 -0.01440 0.05564  239 GLN A CG  
748  C CD  . GLN A 59  ? 0.26456 0.15808 0.56080 -0.02083 -0.00974 0.05717  239 GLN A CD  
749  O OE1 . GLN A 59  ? 0.26820 0.15867 0.56244 -0.02266 0.00198  0.06801  239 GLN A OE1 
750  N NE2 . GLN A 59  ? 0.29142 0.18409 0.60564 -0.02567 -0.01925 0.04660  239 GLN A NE2 
759  N N   . LEU A 60  ? 0.27542 0.22855 0.57249 -0.02439 0.01879  0.07404  240 LEU A N   
760  C CA  . LEU A 60  ? 0.21717 0.18711 0.50922 -0.02557 0.03116  0.08023  240 LEU A CA  
761  C C   . LEU A 60  ? 0.26089 0.22881 0.52628 -0.02085 0.03978  0.09250  240 LEU A C   
762  O O   . LEU A 60  ? 0.31836 0.27119 0.57366 -0.01745 0.03880  0.09762  240 LEU A O   
763  C CB  . LEU A 60  ? 0.23443 0.21181 0.54339 -0.03241 0.04089  0.08041  240 LEU A CB  
764  C CG  . LEU A 60  ? 0.26740 0.25178 0.60328 -0.03614 0.03456  0.06886  240 LEU A CG  
765  C CD1 . LEU A 60  ? 0.25507 0.24892 0.59165 -0.03226 0.02552  0.06091  240 LEU A CD1 
766  C CD2 . LEU A 60  ? 0.20880 0.17988 0.56003 -0.03848 0.02434  0.06318  240 LEU A CD2 
778  N N   . VAL A 61  ? 0.23350 0.21726 0.48594 -0.01980 0.04743  0.09616  241 VAL A N   
779  C CA  . VAL A 61  ? 0.21820 0.20418 0.44333 -0.01476 0.05473  0.10693  241 VAL A CA  
780  C C   . VAL A 61  ? 0.30024 0.27819 0.52154 -0.01677 0.06300  0.11528  241 VAL A C   
781  O O   . VAL A 61  ? 0.29450 0.26206 0.49993 -0.01145 0.06290  0.12316  241 VAL A O   
782  C CB  . VAL A 61  ? 0.36195 0.36763 0.57280 -0.01429 0.06060  0.10628  241 VAL A CB  
783  C CG1 . VAL A 61  ? 0.28178 0.29176 0.46425 -0.00998 0.06768  0.11555  241 VAL A CG1 
784  C CG2 . VAL A 61  ? 0.36161 0.37312 0.57078 -0.01200 0.05203  0.10038  241 VAL A CG2 
794  N N   . SER A 62  ? 0.32380 0.30582 0.55859 -0.02426 0.06977  0.11353  242 SER A N   
795  C CA  A SER A 62  ? 0.33637 0.31041 0.56731 -0.02851 0.07805  0.12164  242 SER A CA  
796  C CA  B SER A 62  ? 0.33613 0.31017 0.56707 -0.02851 0.07805  0.12164  242 SER A CA  
797  C C   . SER A 62  ? 0.40607 0.37015 0.66321 -0.03562 0.07582  0.11692  242 SER A C   
798  O O   . SER A 62  ? 0.31494 0.28897 0.59135 -0.04104 0.07683  0.10889  242 SER A O   
799  C CB  A SER A 62  ? 0.38384 0.37197 0.60237 -0.03239 0.08906  0.12395  242 SER A CB  
800  C CB  B SER A 62  ? 0.38383 0.37196 0.60236 -0.03239 0.08906  0.12395  242 SER A CB  
801  O OG  A SER A 62  ? 0.51241 0.49203 0.72660 -0.03815 0.09676  0.13204  242 SER A OG  
802  O OG  B SER A 62  ? 0.51302 0.49271 0.72771 -0.03829 0.09677  0.13188  242 SER A OG  
812  N N   . GLN A 63  ? 0.37739 0.32178 0.63450 -0.03518 0.07218  0.12113  243 GLN A N   
813  C CA  . GLN A 63  ? 0.38567 0.31908 0.66503 -0.04239 0.06945  0.11660  243 GLN A CA  
814  C C   . GLN A 63  ? 0.47810 0.40679 0.75490 -0.05061 0.08073  0.12529  243 GLN A C   
815  O O   . GLN A 63  ? 0.32432 0.24503 0.57917 -0.04862 0.08590  0.13654  243 GLN A O   
816  C CB  . GLN A 63  ? 0.34789 0.26023 0.62716 -0.03793 0.05801  0.11411  243 GLN A CB  
817  C CG  . GLN A 63  ? 0.36288 0.26228 0.66252 -0.04565 0.05441  0.10908  243 GLN A CG  
818  C CD  . GLN A 63  ? 0.42095 0.33199 0.74626 -0.04945 0.04719  0.09556  243 GLN A CD  
819  O OE1 . GLN A 63  ? 0.33178 0.25896 0.65958 -0.04618 0.04453  0.09004  243 GLN A OE1 
820  N NE2 . GLN A 63  ? 0.45885 0.36143 0.80282 -0.05637 0.04348  0.09028  243 GLN A NE2 
829  N N   . LYS A 64  ? 0.32303 0.25671 0.62178 -0.06001 0.08391  0.11996  244 LYS A N   
830  C CA  . LYS A 64  ? 0.45938 0.39025 0.75736 -0.07011 0.09518  0.12717  244 LYS A CA  
831  C C   . LYS A 64  ? 0.44357 0.36663 0.76789 -0.07874 0.09190  0.12110  244 LYS A C   
832  O O   . LYS A 64  ? 0.42893 0.34428 0.76651 -0.07574 0.08009  0.11306  244 LYS A O   
833  C CB  . LYS A 64  ? 0.51436 0.46699 0.80747 -0.07370 0.10607  0.12683  244 LYS A CB  
834  C CG  . LYS A 64  ? 0.51707 0.47585 0.78053 -0.06649 0.10941  0.13336  244 LYS A CG  
835  C CD  . LYS A 64  ? 0.49665 0.47432 0.75240 -0.07159 0.12011  0.13228  244 LYS A CD  
842  N N   . SER A 65  ? 0.45143 0.37678 0.78229 -0.09021 0.10210  0.12454  245 SER A N   
843  C CA  . SER A 65  ? 0.49309 0.41000 0.84701 -0.09996 0.10017  0.12046  245 SER A CA  
844  C C   . SER A 65  ? 0.37240 0.29979 0.75449 -0.09831 0.08962  0.10534  245 SER A C   
845  O O   . SER A 65  ? 0.42166 0.33890 0.82119 -0.10344 0.08315  0.10032  245 SER A O   
846  C CB  . SER A 65  ? 0.51506 0.43959 0.87294 -0.11338 0.11408  0.12520  245 SER A CB  
847  O OG  . SER A 65  ? 0.45874 0.40969 0.83057 -0.11476 0.11876  0.11671  245 SER A OG  
853  N N   . ASP A 66  ? 0.46020 0.40659 0.84597 -0.09140 0.08693  0.09790  246 ASP A N   
854  C CA  . ASP A 66  ? 0.32795 0.28495 0.73947 -0.08975 0.07648  0.08395  246 ASP A CA  
855  C C   . ASP A 66  ? 0.31863 0.26324 0.72860 -0.08164 0.06041  0.07840  246 ASP A C   
856  O O   . ASP A 66  ? 0.31331 0.24853 0.70127 -0.07409 0.05774  0.08355  246 ASP A O   
857  C CB  . ASP A 66  ? 0.30496 0.28472 0.71939 -0.08547 0.07920  0.07817  246 ASP A CB  
858  C CG  . ASP A 66  ? 0.31463 0.31005 0.74095 -0.09442 0.09182  0.07742  246 ASP A CG  
859  O OD1 . ASP A 66  ? 0.43700 0.43472 0.88785 -0.10216 0.09111  0.07220  246 ASP A OD1 
860  O OD2 . ASP A 66  ? 0.42025 0.42625 0.83085 -0.09410 0.10232  0.08163  246 ASP A OD2 
865  N N   . SER A 67  ? 0.31845 0.26380 0.75124 -0.08340 0.04937  0.06733  247 SER A N   
866  C CA  . SER A 67  ? 0.38234 0.31870 0.81371 -0.07629 0.03278  0.05953  247 SER A CA  
867  C C   . SER A 67  ? 0.36013 0.31046 0.78712 -0.06730 0.02640  0.05404  247 SER A C   
868  O O   . SER A 67  ? 0.27028 0.23854 0.70782 -0.06744 0.03039  0.05077  247 SER A O   
869  C CB  . SER A 67  ? 0.35106 0.28467 0.80658 -0.08148 0.02240  0.04916  247 SER A CB  
870  O OG  . SER A 67  ? 0.44785 0.37742 0.90152 -0.07436 0.00544  0.03961  247 SER A OG  
876  N N   . SER A 68  ? 0.32335 0.26425 0.73350 -0.05965 0.01635  0.05267  248 SER A N   
877  C CA  . SER A 68  ? 0.41133 0.36303 0.81413 -0.05205 0.00979  0.04831  248 SER A CA  
878  C C   . SER A 68  ? 0.34077 0.30381 0.76472 -0.05164 -0.00140 0.03624  248 SER A C   
879  O O   . SER A 68  ? 0.29649 0.27180 0.71970 -0.04724 -0.00351 0.03318  248 SER A O   
880  C CB  . SER A 68  ? 0.34271 0.28077 0.72305 -0.04514 0.00044  0.04816  248 SER A CB  
881  O OG  . SER A 68  ? 0.26185 0.18624 0.64656 -0.04573 -0.01218 0.04020  248 SER A OG  
887  N N   . LYS A 69  ? 0.25642 0.21466 0.69845 -0.05593 -0.00912 0.02942  249 LYS A N   
888  C CA  . LYS A 69  ? 0.34927 0.31720 0.81051 -0.05457 -0.02137 0.01821  249 LYS A CA  
889  C C   . LYS A 69  ? 0.24797 0.23337 0.72958 -0.05752 -0.01236 0.01707  249 LYS A C   
890  O O   . LYS A 69  ? 0.24160 0.23633 0.73680 -0.05427 -0.02145 0.00868  249 LYS A O   
891  C CB  . LYS A 69  ? 0.31016 0.26782 0.78349 -0.05844 -0.03253 0.01115  249 LYS A CB  
892  C CG  . LYS A 69  ? 0.34438 0.28572 0.79715 -0.05396 -0.04526 0.00794  249 LYS A CG  
893  C CD  . LYS A 69  ? 0.52580 0.45620 0.98919 -0.05832 -0.05556 0.00039  249 LYS A CD  
894  C CE  . LYS A 69  ? 0.38663 0.30047 0.82712 -0.05345 -0.06796 -0.00441 249 LYS A CE  
903  N N   . ASP A 70  ? 0.30527 0.29444 0.78763 -0.06346 0.00500  0.02506  250 ASP A N   
904  C CA  . ASP A 70  ? 0.28525 0.29166 0.78194 -0.06599 0.01528  0.02373  250 ASP A CA  
905  C C   . ASP A 70  ? 0.23246 0.24806 0.71464 -0.05895 0.01839  0.02465  250 ASP A C   
906  O O   . ASP A 70  ? 0.22926 0.25889 0.72229 -0.05930 0.02432  0.02106  250 ASP A O   
907  C CB  . ASP A 70  ? 0.27002 0.27717 0.76815 -0.07565 0.03294  0.03204  250 ASP A CB  
908  C CG  . ASP A 70  ? 0.45152 0.45049 0.96682 -0.08456 0.03103  0.03067  250 ASP A CG  
909  O OD1 . ASP A 70  ? 0.44806 0.45521 0.98892 -0.08708 0.02440  0.02143  250 ASP A OD1 
910  O OD2 . ASP A 70  ? 0.48709 0.47071 0.99003 -0.08911 0.03589  0.03886  250 ASP A OD2 
915  N N   . ILE A 71  ? 0.22138 0.22934 0.67942 -0.05302 0.01457  0.02884  251 ILE A N   
916  C CA  . ILE A 71  ? 0.26735 0.28252 0.70878 -0.04724 0.01754  0.03042  251 ILE A CA  
917  C C   . ILE A 71  ? 0.31852 0.33118 0.75549 -0.03988 0.00029  0.02343  251 ILE A C   
918  O O   . ILE A 71  ? 0.25488 0.27557 0.69382 -0.03604 -0.00265 0.01855  251 ILE A O   
919  C CB  . ILE A 71  ? 0.20360 0.21378 0.61826 -0.04711 0.02870  0.04212  251 ILE A CB  
920  C CG1 . ILE A 71  ? 0.28612 0.29943 0.70132 -0.05446 0.04581  0.04942  251 ILE A CG1 
921  C CG2 . ILE A 71  ? 0.18681 0.20396 0.58269 -0.04133 0.02996  0.04317  251 ILE A CG2 
922  C CD1 . ILE A 71  ? 0.30120 0.30389 0.69252 -0.05515 0.05390  0.06168  251 ILE A CD1 
934  N N   . ARG A 72  ? 0.25130 0.25162 0.68004 -0.03810 -0.01149 0.02268  252 ARG A N   
935  C CA  . ARG A 72  ? 0.18700 0.18356 0.60871 -0.03220 -0.02919 0.01581  252 ARG A CA  
936  C C   . ARG A 72  ? 0.20028 0.18673 0.62925 -0.03326 -0.04282 0.00975  252 ARG A C   
937  O O   . ARG A 72  ? 0.21041 0.18650 0.63432 -0.03651 -0.04013 0.01317  252 ARG A O   
938  C CB  . ARG A 72  ? 0.17613 0.16804 0.56969 -0.02845 -0.02991 0.02090  252 ARG A CB  
939  C CG  . ARG A 72  ? 0.18346 0.16320 0.56210 -0.03002 -0.02567 0.02763  252 ARG A CG  
940  C CD  . ARG A 72  ? 0.30128 0.27902 0.65347 -0.02658 -0.02230 0.03412  252 ARG A CD  
941  N NE  . ARG A 72  ? 0.26071 0.23328 0.59862 -0.02247 -0.03803 0.02776  252 ARG A NE  
942  C CZ  . ARG A 72  ? 0.24954 0.21756 0.56267 -0.01933 -0.03855 0.03147  252 ARG A CZ  
943  N NH1 . ARG A 72  ? 0.29240 0.26132 0.59294 -0.01880 -0.02459 0.04211  252 ARG A NH1 
944  N NH2 . ARG A 72  ? 0.24786 0.20980 0.54626 -0.01619 -0.05345 0.02478  252 ARG A NH2 
958  N N   . GLY A 73  ? 0.23031 0.21829 0.66925 -0.03031 -0.05759 0.00079  253 GLY A N   
959  C CA  . GLY A 73  ? 0.23026 0.20986 0.67543 -0.03119 -0.07156 -0.00603 253 GLY A CA  
960  C C   . GLY A 73  ? 0.27085 0.23980 0.69207 -0.02654 -0.08721 -0.00974 253 GLY A C   
961  O O   . GLY A 73  ? 0.41371 0.37592 0.83744 -0.02646 -0.10063 -0.01670 253 GLY A O   
965  N N   . ASP A 74  ? 0.27530 0.24239 0.67217 -0.02322 -0.08574 -0.00563 254 ASP A N   
966  C CA  . ASP A 74  ? 0.27474 0.23183 0.64573 -0.01938 -0.09977 -0.00946 254 ASP A CA  
967  C C   . ASP A 74  ? 0.30777 0.25143 0.66206 -0.02095 -0.09750 -0.00809 254 ASP A C   
968  O O   . ASP A 74  ? 0.26463 0.20628 0.62173 -0.02385 -0.08362 -0.00136 254 ASP A O   
969  C CB  . ASP A 74  ? 0.32468 0.28539 0.67634 -0.01551 -0.10016 -0.00656 254 ASP A CB  
970  C CG  . ASP A 74  ? 0.18151 0.14664 0.52685 -0.01722 -0.08306 0.00261  254 ASP A CG  
971  O OD1 . ASP A 74  ? 0.27877 0.24818 0.64000 -0.02083 -0.06925 0.00748  254 ASP A OD1 
972  O OD2 . ASP A 74  ? 0.19056 0.15411 0.51342 -0.01522 -0.08333 0.00537  254 ASP A OD2 
977  N N   . LYS A 75  ? 0.22720 0.15975 0.56201 -0.01836 -0.11122 -0.01461 255 LYS A N   
978  C CA  . LYS A 75  ? 0.26184 0.17901 0.57569 -0.01762 -0.11060 -0.01537 255 LYS A CA  
979  C C   . LYS A 75  ? 0.34689 0.25966 0.62975 -0.01300 -0.11522 -0.01579 255 LYS A C   
980  O O   . LYS A 75  ? 0.29669 0.21204 0.57014 -0.01101 -0.12702 -0.01994 255 LYS A O   
981  C CB  . LYS A 75  ? 0.34069 0.24660 0.65655 -0.01871 -0.12177 -0.02429 255 LYS A CB  
982  C CG  . LYS A 75  ? 0.26531 0.17338 0.58041 -0.01691 -0.13884 -0.03220 255 LYS A CG  
983  C CD  . LYS A 75  ? 0.31870 0.21734 0.64080 -0.01917 -0.14830 -0.04047 255 LYS A CD  
984  C CE  . LYS A 75  ? 0.39283 0.29656 0.74789 -0.02493 -0.14125 -0.03890 255 LYS A CE  
985  N NZ  . LYS A 75  ? 0.31436 0.20985 0.67773 -0.02783 -0.15186 -0.04753 255 LYS A NZ  
999  N N   . ILE A 76  ? 0.37796 0.28300 0.64380 -0.01066 -0.10571 -0.01085 256 ILE A N   
1000 C CA  . ILE A 76  ? 0.33844 0.24142 0.57733 -0.00619 -0.10620 -0.00904 256 ILE A CA  
1001 C C   . ILE A 76  ? 0.31558 0.20243 0.53058 -0.00051 -0.10664 -0.01209 256 ILE A C   
1002 O O   . ILE A 76  ? 0.32919 0.20643 0.54903 0.00004  -0.10346 -0.01353 256 ILE A O   
1003 C CB  . ILE A 76  ? 0.29369 0.20729 0.53519 -0.00592 -0.09153 0.00240  256 ILE A CB  
1004 C CG1 . ILE A 76  ? 0.30400 0.21286 0.54542 -0.00384 -0.07652 0.01094  256 ILE A CG1 
1005 C CG2 . ILE A 76  ? 0.29878 0.22828 0.56715 -0.01086 -0.08896 0.00426  256 ILE A CG2 
1006 C CD1 . ILE A 76  ? 0.31091 0.21695 0.52107 0.00460  -0.07203 0.01412  256 ILE A CD1 
1018 N N   . THR A 77  ? 0.41387 0.30222 0.59978 0.00429  -0.10917 -0.01306 257 THR A N   
1019 C CA  . THR A 77  ? 0.41887 0.30259 0.57771 0.01175  -0.10490 -0.01458 257 THR A CA  
1020 C C   . THR A 77  ? 0.37455 0.27468 0.50792 0.01527  -0.09759 -0.00844 257 THR A C   
1021 O O   . THR A 77  ? 0.39222 0.30305 0.52479 0.01162  -0.09934 -0.00544 257 THR A O   
1022 C CB  . THR A 77  ? 0.29733 0.16731 0.44125 0.01288  -0.11879 -0.02820 257 THR A CB  
1023 O OG1 . THR A 77  ? 0.31627 0.18065 0.44134 0.02083  -0.11271 -0.03065 257 THR A OG1 
1024 C CG2 . THR A 77  ? 0.35388 0.23009 0.47566 0.01096  -0.12963 -0.03277 257 THR A CG2 
1032 N N   . TRP A 78  ? 0.30383 0.20595 0.41765 0.02250  -0.08952 -0.00688 258 TRP A N   
1033 C CA  . TRP A 78  ? 0.26778 0.18684 0.35826 0.02563  -0.08172 -0.00134 258 TRP A CA  
1034 C C   . TRP A 78  ? 0.37388 0.29318 0.43450 0.02883  -0.08748 -0.01040 258 TRP A C   
1035 O O   . TRP A 78  ? 0.36919 0.27769 0.42456 0.03357  -0.09015 -0.01848 258 TRP A O   
1036 C CB  . TRP A 78  ? 0.29051 0.21636 0.38281 0.03146  -0.06704 0.00856  258 TRP A CB  
1037 C CG  . TRP A 78  ? 0.26616 0.19346 0.38353 0.02738  -0.05948 0.01848  258 TRP A CG  
1038 C CD1 . TRP A 78  ? 0.26172 0.17600 0.40217 0.02623  -0.05701 0.02104  258 TRP A CD1 
1039 C CD2 . TRP A 78  ? 0.21216 0.15461 0.33338 0.02310  -0.05278 0.02669  258 TRP A CD2 
1040 N NE1 . TRP A 78  ? 0.21674 0.13854 0.37467 0.02115  -0.04840 0.03070  258 TRP A NE1 
1041 C CE2 . TRP A 78  ? 0.34208 0.28136 0.48873 0.01964  -0.04569 0.03372  258 TRP A CE2 
1042 C CE3 . TRP A 78  ? 0.25890 0.21651 0.36407 0.02136  -0.05179 0.02842  258 TRP A CE3 
1043 C CZ2 . TRP A 78  ? 0.24728 0.19936 0.40335 0.01516  -0.03720 0.04152  258 TRP A CZ2 
1044 C CZ3 . TRP A 78  ? 0.16314 0.13175 0.27823 0.01727  -0.04422 0.03595  258 TRP A CZ3 
1045 C CH2 . TRP A 78  ? 0.29956 0.26602 0.43973 0.01452  -0.03678 0.04201  258 TRP A CH2 
1056 N N   . ILE A 79  ? 0.29218 0.22334 0.33300 0.02580  -0.08887 -0.00928 259 ILE A N   
1057 C CA  . ILE A 79  ? 0.30247 0.23556 0.31291 0.02627  -0.09394 -0.01706 259 ILE A CA  
1058 C C   . ILE A 79  ? 0.28969 0.24232 0.28056 0.02787  -0.08324 -0.01094 259 ILE A C   
1059 O O   . ILE A 79  ? 0.28351 0.24623 0.27759 0.02405  -0.07896 -0.00242 259 ILE A O   
1060 C CB  . ILE A 79  ? 0.33370 0.25965 0.33636 0.01877  -0.10872 -0.02197 259 ILE A CB  
1061 C CG1 . ILE A 79  ? 0.35588 0.26371 0.37621 0.01719  -0.12109 -0.03009 259 ILE A CG1 
1062 C CG2 . ILE A 79  ? 0.37512 0.30513 0.34198 0.01752  -0.11180 -0.02745 259 ILE A CG2 
1063 C CD1 . ILE A 79  ? 0.44221 0.33941 0.45750 0.02269  -0.12144 -0.03982 259 ILE A CD1 
1075 N N   . GLU A 80  ? 0.37969 0.33837 0.35149 0.03351  -0.07877 -0.01612 260 GLU A N   
1076 C CA  A GLU A 80  ? 0.40765 0.38700 0.36025 0.03427  -0.06950 -0.01203 260 GLU A CA  
1077 C CA  B GLU A 80  ? 0.40656 0.38591 0.35917 0.03426  -0.06950 -0.01202 260 GLU A CA  
1078 C C   . GLU A 80  ? 0.36270 0.34603 0.28894 0.02623  -0.07536 -0.01516 260 GLU A C   
1079 O O   . GLU A 80  ? 0.53921 0.53809 0.45279 0.02260  -0.06944 -0.00950 260 GLU A O   
1080 C CB  A GLU A 80  ? 0.37213 0.35892 0.31801 0.04426  -0.06180 -0.01669 260 GLU A CB  
1081 C CB  B GLU A 80  ? 0.37294 0.35976 0.31881 0.04424  -0.06179 -0.01668 260 GLU A CB  
1082 C CG  A GLU A 80  ? 0.45753 0.46743 0.38125 0.04445  -0.05394 -0.01615 260 GLU A CG  
1083 C CG  B GLU A 80  ? 0.46502 0.44751 0.43385 0.05282  -0.05549 -0.01156 260 GLU A CG  
1092 N N   . GLY A 81  ? 0.41124 0.37993 0.32793 0.02277  -0.08728 -0.02382 261 GLY A N   
1093 C CA  . GLY A 81  ? 0.53830 0.50684 0.42753 0.01462  -0.09437 -0.02634 261 GLY A CA  
1094 C C   . GLY A 81  ? 0.40674 0.37766 0.26882 0.01576  -0.09408 -0.03686 261 GLY A C   
1095 O O   . GLY A 81  ? 0.33588 0.30547 0.18294 0.00707  -0.09619 -0.03814 261 GLY A O   
1099 N N   . LYS A 82  ? 0.40729 0.38591 0.27241 0.02493  -0.08488 -0.04198 262 LYS A N   
1100 C CA  . LYS A 82  ? 0.43567 0.41930 0.27701 0.02729  -0.08249 -0.05349 262 LYS A CA  
1101 C C   . LYS A 82  ? 0.43151 0.39676 0.27733 0.03265  -0.08965 -0.06592 262 LYS A C   
1102 O O   . LYS A 82  ? 0.42402 0.39194 0.25079 0.03545  -0.08765 -0.07750 262 LYS A O   
1103 C CB  . LYS A 82  ? 0.54538 0.55238 0.38633 0.03497  -0.06740 -0.05273 262 LYS A CB  
1104 C CG  . LYS A 82  ? 0.55505 0.58239 0.38816 0.02800  -0.05939 -0.04234 262 LYS A CG  
1105 C CD  . LYS A 82  ? 0.49365 0.54486 0.32825 0.03456  -0.04513 -0.04268 262 LYS A CD  
1106 C CE  . LYS A 82  ? 0.50820 0.56955 0.34555 0.02251  -0.03529 -0.03084 262 LYS A CE  
1115 N N   . GLU A 83  ? 0.48857 0.43585 0.35916 0.03364  -0.09751 -0.06458 263 GLU A N   
1116 C CA  . GLU A 83  ? 0.49731 0.42598 0.37394 0.03801  -0.10460 -0.07666 263 GLU A CA  
1117 C C   . GLU A 83  ? 0.54585 0.46348 0.39717 0.03050  -0.11754 -0.08656 263 GLU A C   
1118 O O   . GLU A 83  ? 0.52021 0.43812 0.36249 0.02088  -0.12371 -0.07993 263 GLU A O   
1119 C CB  . GLU A 83  ? 0.43197 0.34514 0.34252 0.03883  -0.10973 -0.07208 263 GLU A CB  
1120 C CG  . GLU A 83  ? 0.33102 0.25223 0.26534 0.04542  -0.09766 -0.06135 263 GLU A CG  
1121 C CD  . GLU A 83  ? 0.43380 0.36623 0.37635 0.03952  -0.09463 -0.04712 263 GLU A CD  
1122 O OE1 . GLU A 83  ? 0.46245 0.40114 0.38726 0.03192  -0.09874 -0.04525 263 GLU A OE1 
1123 O OE2 . GLU A 83  ? 0.38188 0.31576 0.34768 0.04227  -0.08813 -0.03790 263 GLU A OE2 
1130 N N   . PRO A 84  ? 0.45043 0.35851 0.29136 0.03455  -0.12037 -0.10131 264 PRO A N   
1131 C CA  . PRO A 84  ? 0.48086 0.38145 0.30493 0.02579  -0.12787 -0.10615 264 PRO A CA  
1132 C C   . PRO A 84  ? 0.48582 0.37132 0.32869 0.01956  -0.14126 -0.10096 264 PRO A C   
1133 O O   . PRO A 84  ? 0.55291 0.42471 0.42109 0.02346  -0.14901 -0.10314 264 PRO A O   
1134 C CB  . PRO A 84  ? 0.65850 0.55080 0.47549 0.03317  -0.12707 -0.12311 264 PRO A CB  
1135 C CG  . PRO A 84  ? 0.57439 0.46118 0.41538 0.04562  -0.12338 -0.12621 264 PRO A CG  
1136 C CD  . PRO A 84  ? 0.50879 0.41524 0.35986 0.04642  -0.11213 -0.11016 264 PRO A CD  
1144 N N   . GLY A 85  ? 0.58640 0.47561 0.41906 0.00972  -0.14313 -0.09421 265 GLY A N   
1145 C CA  . GLY A 85  ? 0.55591 0.43456 0.40583 0.00516  -0.15458 -0.08855 265 GLY A CA  
1146 C C   . GLY A 85  ? 0.47416 0.35662 0.34299 0.00388  -0.15481 -0.07589 265 GLY A C   
1147 O O   . GLY A 85  ? 0.54378 0.41870 0.43059 0.00133  -0.16358 -0.07138 265 GLY A O   
1151 N N   . CYS A 86  ? 0.51811 0.41321 0.38390 0.00587  -0.14506 -0.07036 266 CYS A N   
1152 C CA  . CYS A 86  ? 0.51041 0.41110 0.39185 0.00421  -0.14356 -0.05852 266 CYS A CA  
1153 C C   . CYS A 86  ? 0.36868 0.28676 0.23184 -0.00091 -0.13175 -0.04973 266 CYS A C   
1154 O O   . CYS A 86  ? 0.45904 0.38629 0.32929 -0.00095 -0.12588 -0.04144 266 CYS A O   
1155 C CB  . CYS A 86  ? 0.39231 0.29257 0.29298 0.01115  -0.14368 -0.05951 266 CYS A CB  
1156 S SG  . CYS A 86  ? 0.44142 0.32460 0.37822 0.01461  -0.15056 -0.06555 266 CYS A SG  
1162 N N   . GLU A 87  ? 0.56207 0.48611 0.40350 -0.00593 -0.12792 -0.05186 267 GLU A N   
1163 C CA  . GLU A 87  ? 0.44696 0.39054 0.27450 -0.01128 -0.11588 -0.04543 267 GLU A CA  
1164 C C   . GLU A 87  ? 0.33028 0.27312 0.16710 -0.01507 -0.11700 -0.03488 267 GLU A C   
1165 O O   . GLU A 87  ? 0.39241 0.34912 0.23008 -0.01629 -0.10755 -0.02834 267 GLU A O   
1166 C CB  . GLU A 87  ? 0.52354 0.47454 0.32948 -0.01576 -0.11306 -0.05129 267 GLU A CB  
1167 C CG  . GLU A 87  ? 0.56868 0.52393 0.36258 -0.01258 -0.10830 -0.06240 267 GLU A CG  
1168 C CD  . GLU A 87  ? 0.51252 0.44673 0.30797 -0.00836 -0.11971 -0.07297 267 GLU A CD  
1169 O OE1 . GLU A 87  ? 0.56117 0.48069 0.36622 -0.00979 -0.13130 -0.07119 267 GLU A OE1 
1170 O OE2 . GLU A 87  ? 0.59956 0.53223 0.38803 -0.00289 -0.11693 -0.08374 267 GLU A OE2 
1177 N N   . THR A 88  ? 0.41449 0.34100 0.25880 -0.01632 -0.12858 -0.03379 268 THR A N   
1178 C CA  . THR A 88  ? 0.34448 0.26716 0.19669 -0.01895 -0.13049 -0.02493 268 THR A CA  
1179 C C   . THR A 88  ? 0.42437 0.34712 0.29831 -0.01608 -0.12938 -0.01996 268 THR A C   
1180 O O   . THR A 88  ? 0.35883 0.28557 0.23603 -0.01812 -0.12486 -0.01293 268 THR A O   
1181 C CB  . THR A 88  ? 0.50353 0.40910 0.35834 -0.02012 -0.14398 -0.02541 268 THR A CB  
1182 O OG1 . THR A 88  ? 0.43261 0.33726 0.26844 -0.02202 -0.14661 -0.03201 268 THR A OG1 
1183 C CG2 . THR A 88  ? 0.37391 0.27534 0.22711 -0.02342 -0.14518 -0.01727 268 THR A CG2 
1191 N N   . ILE A 89  ? 0.35806 0.27611 0.24765 -0.01131 -0.13379 -0.02403 269 ILE A N   
1192 C CA  . ILE A 89  ? 0.37208 0.29383 0.28208 -0.00865 -0.13165 -0.01947 269 ILE A CA  
1193 C C   . ILE A 89  ? 0.31562 0.25510 0.21365 -0.00900 -0.11794 -0.01522 269 ILE A C   
1194 O O   . ILE A 89  ? 0.33876 0.28494 0.24534 -0.00987 -0.11285 -0.00831 269 ILE A O   
1195 C CB  . ILE A 89  ? 0.33964 0.25398 0.27040 -0.00339 -0.13933 -0.02543 269 ILE A CB  
1196 C CG1 . ILE A 89  ? 0.48738 0.38717 0.43502 -0.00369 -0.15174 -0.02925 269 ILE A CG1 
1197 C CG2 . ILE A 89  ? 0.42093 0.34248 0.37429 -0.00104 -0.13663 -0.01991 269 ILE A CG2 
1198 C CD1 . ILE A 89  ? 0.55468 0.44589 0.51518 -0.00007 -0.15866 -0.03870 269 ILE A CD1 
1210 N N   . GLY A 90  ? 0.36138 0.31016 0.24047 -0.00822 -0.11130 -0.01981 270 GLY A N   
1211 C CA  . GLY A 90  ? 0.36083 0.33023 0.23015 -0.00866 -0.09739 -0.01614 270 GLY A CA  
1212 C C   . GLY A 90  ? 0.29842 0.27693 0.16305 -0.01382 -0.09059 -0.01057 270 GLY A C   
1213 O O   . GLY A 90  ? 0.49661 0.48779 0.36447 -0.01333 -0.08160 -0.00564 270 GLY A O   
1217 N N   . LEU A 91  ? 0.37886 0.34896 0.23562 -0.01751 -0.09567 -0.01179 271 LEU A N   
1218 C CA  . LEU A 91  ? 0.32858 0.30041 0.18076 -0.02112 -0.09218 -0.00676 271 LEU A CA  
1219 C C   . LEU A 91  ? 0.30727 0.27068 0.17443 -0.02204 -0.09464 -0.00034 271 LEU A C   
1220 O O   . LEU A 91  ? 0.35164 0.32173 0.21886 -0.02336 -0.08735 0.00387  271 LEU A O   
1221 C CB  . LEU A 91  ? 0.35869 0.31903 0.19857 -0.02469 -0.09980 -0.00844 271 LEU A CB  
1222 C CG  . LEU A 91  ? 0.48058 0.43817 0.31077 -0.02893 -0.09822 -0.00359 271 LEU A CG  
1223 C CD1 . LEU A 91  ? 0.37910 0.31786 0.21841 -0.03127 -0.10728 0.00204  271 LEU A CD1 
1224 C CD2 . LEU A 91  ? 0.40003 0.37001 0.22569 -0.02950 -0.08666 -0.00081 271 LEU A CD2 
1236 N N   . LEU A 92  ? 0.29786 0.24632 0.17934 -0.02070 -0.10537 -0.00045 272 LEU A N   
1237 C CA  . LEU A 92  ? 0.30357 0.24592 0.20225 -0.02063 -0.10816 0.00446  272 LEU A CA  
1238 C C   . LEU A 92  ? 0.31952 0.27663 0.22497 -0.01900 -0.09828 0.00754  272 LEU A C   
1239 O O   . LEU A 92  ? 0.22099 0.18093 0.13035 -0.02076 -0.09394 0.01199  272 LEU A O   
1240 C CB  . LEU A 92  ? 0.31207 0.23987 0.23046 -0.01774 -0.12116 0.00220  272 LEU A CB  
1241 C CG  . LEU A 92  ? 0.34301 0.26945 0.28761 -0.01580 -0.12384 0.00522  272 LEU A CG  
1242 C CD1 . LEU A 92  ? 0.33818 0.25774 0.28436 -0.01820 -0.12597 0.00921  272 LEU A CD1 
1243 C CD2 . LEU A 92  ? 0.24244 0.16051 0.21114 -0.01216 -0.13445 0.00096  272 LEU A CD2 
1255 N N   . MET A 93  ? 0.30473 0.27022 0.21070 -0.01538 -0.09539 0.00520  273 MET A N   
1256 C CA  . MET A 93  ? 0.21247 0.19229 0.12314 -0.01305 -0.08646 0.00914  273 MET A CA  
1257 C C   . MET A 93  ? 0.20199 0.19702 0.10012 -0.01432 -0.07339 0.01066  273 MET A C   
1258 O O   . MET A 93  ? 0.22805 0.22944 0.13140 -0.01439 -0.06686 0.01489  273 MET A O   
1259 C CB  . MET A 93  ? 0.24992 0.23298 0.16029 -0.00774 -0.08747 0.00631  273 MET A CB  
1260 C CG  . MET A 93  ? 0.37213 0.34119 0.30478 -0.00373 -0.10028 0.00481  273 MET A CG  
1261 S SD  . MET A 93  ? 0.27611 0.24664 0.21503 0.00487  -0.09440 -0.00092 273 MET A SD  
1262 C CE  . MET A 93  ? 0.25953 0.25148 0.20121 0.00913  -0.07602 0.00709  273 MET A CE  
1272 N N   . SER A 94  ? 0.34916 0.34880 0.23259 -0.01438 -0.07007 0.00650  274 SER A N   
1273 C CA  . SER A 94  ? 0.31670 0.32488 0.19170 -0.01333 -0.06001 0.00680  274 SER A CA  
1274 C C   . SER A 94  ? 0.25265 0.25297 0.12982 -0.01899 -0.06070 0.01096  274 SER A C   
1275 O O   . SER A 94  ? 0.28401 0.28745 0.16038 -0.02117 -0.05380 0.01374  274 SER A O   
1276 C CB  . SER A 94  ? 0.39163 0.40266 0.25160 -0.01165 -0.05870 0.00169  274 SER A CB  
1277 O OG  . SER A 94  ? 0.63872 0.64744 0.48847 -0.01771 -0.05369 0.00472  274 SER A OG  
1283 N N   . SER A 95  ? 0.31008 0.29581 0.18806 -0.02341 -0.07061 0.01197  275 SER A N   
1284 C CA  . SER A 95  ? 0.32456 0.29952 0.20372 -0.02834 -0.07322 0.01605  275 SER A CA  
1285 C C   . SER A 95  ? 0.22899 0.20576 0.12165 -0.02792 -0.07128 0.01928  275 SER A C   
1286 O O   . SER A 95  ? 0.39014 0.36802 0.28213 -0.03072 -0.06655 0.02170  275 SER A O   
1287 C CB  . SER A 95  ? 0.35117 0.30651 0.22894 -0.03101 -0.08622 0.01642  275 SER A CB  
1288 O OG  . SER A 95  ? 0.31307 0.26658 0.17568 -0.03255 -0.08782 0.01409  275 SER A OG  
1294 N N   . MET A 96  ? 0.36822 0.34475 0.27360 -0.02485 -0.07558 0.01937  276 MET A N   
1295 C CA  . MET A 96  ? 0.27859 0.25930 0.19746 -0.02425 -0.07358 0.02295  276 MET A CA  
1296 C C   . MET A 96  ? 0.33130 0.32815 0.24497 -0.02341 -0.05998 0.02396  276 MET A C   
1297 O O   . MET A 96  ? 0.25529 0.25403 0.17148 -0.02596 -0.05583 0.02643  276 MET A O   
1298 C CB  . MET A 96  ? 0.18957 0.16972 0.12483 -0.02044 -0.07985 0.02331  276 MET A CB  
1299 C CG  . MET A 96  ? 0.32916 0.29276 0.28052 -0.01965 -0.09378 0.02153  276 MET A CG  
1300 S SD  . MET A 96  ? 0.32096 0.28525 0.29566 -0.01432 -0.10018 0.01989  276 MET A SD  
1301 C CE  . MET A 96  ? 0.37073 0.31899 0.37085 -0.01336 -0.11373 0.01630  276 MET A CE  
1311 N N   . ASP A 97  ? 0.33407 0.34075 0.24100 -0.01930 -0.05372 0.02137  277 ASP A N   
1312 C CA  . ASP A 97  ? 0.18500 0.20206 0.08941 -0.01738 -0.04214 0.02154  277 ASP A CA  
1313 C C   . ASP A 97  ? 0.24378 0.25986 0.14196 -0.02325 -0.03826 0.02167  277 ASP A C   
1314 O O   . ASP A 97  ? 0.39584 0.41919 0.29783 -0.02692 -0.03169 0.02358  277 ASP A O   
1315 C CB  . ASP A 97  ? 0.18424 0.20607 0.08188 -0.01245 -0.03891 0.01861  277 ASP A CB  
1316 C CG  . ASP A 97  ? 0.34158 0.36668 0.24567 -0.00903 -0.04278 0.02037  277 ASP A CG  
1317 O OD1 . ASP A 97  ? 0.20113 0.22645 0.11789 -0.01039 -0.04670 0.02513  277 ASP A OD1 
1318 O OD2 . ASP A 97  ? 0.33281 0.35999 0.23034 -0.00547 -0.04271 0.01776  277 ASP A OD2 
1323 N N   . ASP A 98  ? 0.20931 0.21775 0.09779 -0.02765 -0.04329 0.02081  278 ASP A N   
1324 C CA  . ASP A 98  ? 0.26833 0.27423 0.14916 -0.03714 -0.04159 0.02278  278 ASP A CA  
1325 C C   . ASP A 98  ? 0.29985 0.29982 0.18648 -0.04055 -0.04298 0.02544  278 ASP A C   
1326 O O   . ASP A 98  ? 0.28040 0.28533 0.16717 -0.04639 -0.03788 0.02671  278 ASP A O   
1327 C CB  . ASP A 98  ? 0.32268 0.31768 0.19027 -0.04138 -0.04799 0.02234  278 ASP A CB  
1328 C CG  . ASP A 98  ? 0.31480 0.30649 0.17209 -0.05217 -0.04629 0.02473  278 ASP A CG  
1329 O OD1 . ASP A 98  ? 0.40905 0.41217 0.26970 -0.05622 -0.03897 0.02526  278 ASP A OD1 
1330 O OD2 . ASP A 98  ? 0.47823 0.45563 0.32427 -0.05730 -0.05294 0.02617  278 ASP A OD2 
1335 N N   . LEU A 99  ? 0.32315 0.31335 0.21583 -0.03706 -0.05050 0.02576  279 LEU A N   
1336 C CA  . LEU A 99  ? 0.32468 0.30886 0.22285 -0.03929 -0.05264 0.02787  279 LEU A CA  
1337 C C   . LEU A 99  ? 0.32476 0.32233 0.23105 -0.03772 -0.04412 0.02849  279 LEU A C   
1338 O O   . LEU A 99  ? 0.30503 0.30382 0.21069 -0.04162 -0.04043 0.02915  279 LEU A O   
1339 C CB  . LEU A 99  ? 0.20364 0.17292 0.10842 -0.03899 -0.06538 0.02941  279 LEU A CB  
1340 C CG  . LEU A 99  ? 0.30824 0.25763 0.20567 -0.04182 -0.07636 0.02979  279 LEU A CG  
1341 C CD1 . LEU A 99  ? 0.49835 0.44928 0.38459 -0.04164 -0.07524 0.02771  279 LEU A CD1 
1342 C CD2 . LEU A 99  ? 0.37119 0.30671 0.28227 -0.03866 -0.08966 0.03006  279 LEU A CD2 
1354 N N   . ILE A 100 ? 0.31088 0.31807 0.22414 -0.03260 -0.04116 0.02851  280 ILE A N   
1355 C CA  . ILE A 100 ? 0.14461 0.16410 0.06552 -0.03161 -0.03310 0.03005  280 ILE A CA  
1356 C C   . ILE A 100 ? 0.16706 0.19617 0.08565 -0.03439 -0.02452 0.02830  280 ILE A C   
1357 O O   . ILE A 100 ? 0.15503 0.19070 0.07795 -0.03735 -0.02018 0.02878  280 ILE A O   
1358 C CB  . ILE A 100 ? 0.13691 0.16440 0.06526 -0.02679 -0.03207 0.03203  280 ILE A CB  
1359 C CG1 . ILE A 100 ? 0.24414 0.26543 0.18269 -0.02735 -0.04284 0.03638  280 ILE A CG1 
1360 C CG2 . ILE A 100 ? 0.14296 0.18502 0.07819 -0.02522 -0.02148 0.03317  280 ILE A CG2 
1361 C CD1 . ILE A 100 ? 0.26022 0.28100 0.20675 -0.03106 -0.04507 0.04037  280 ILE A CD1 
1373 N N   . ARG A 101 ? 0.15196 0.18502 0.06466 -0.03645 -0.02357 0.02698  281 ARG A N   
1374 C CA  . ARG A 101 ? 0.23852 0.28504 0.15169 -0.04284 -0.01823 0.02636  281 ARG A CA  
1375 C C   . ARG A 101 ? 0.20932 0.25024 0.11794 -0.05165 -0.01974 0.02695  281 ARG A C   
1376 O O   . ARG A 101 ? 0.20983 0.26172 0.12302 -0.05646 -0.01601 0.02652  281 ARG A O   
1377 C CB  . ARG A 101 ? 0.31187 0.36294 0.21844 -0.04364 -0.01778 0.02483  281 ARG A CB  
1378 C CG  . ARG A 101 ? 0.37660 0.43742 0.28793 -0.03598 -0.01466 0.02377  281 ARG A CG  
1379 C CD  . ARG A 101 ? 0.32988 0.39851 0.23482 -0.03747 -0.01321 0.02163  281 ARG A CD  
1380 N NE  . ARG A 101 ? 0.42720 0.49472 0.32994 -0.02909 -0.01339 0.01999  281 ARG A NE  
1381 C CZ  . ARG A 101 ? 0.33638 0.38817 0.22942 -0.02482 -0.01902 0.01854  281 ARG A CZ  
1382 N NH1 . ARG A 101 ? 0.29683 0.33502 0.18334 -0.02749 -0.02516 0.01885  281 ARG A NH1 
1383 N NH2 . ARG A 101 ? 0.41658 0.46691 0.30698 -0.01773 -0.01958 0.01647  281 ARG A NH2 
1397 N N   . HIS A 102 ? 0.25015 0.27352 0.14944 -0.05404 -0.02625 0.02787  282 HIS A N   
1398 C CA  . HIS A 102 ? 0.23832 0.25225 0.13154 -0.06219 -0.02861 0.02894  282 HIS A CA  
1399 C C   . HIS A 102 ? 0.23496 0.24715 0.13430 -0.06000 -0.02805 0.02914  282 HIS A C   
1400 O O   . HIS A 102 ? 0.23415 0.24039 0.12878 -0.06643 -0.02881 0.02943  282 HIS A O   
1401 C CB  . HIS A 102 ? 0.29879 0.29261 0.18027 -0.06488 -0.03709 0.03046  282 HIS A CB  
1402 C CG  . HIS A 102 ? 0.40411 0.39803 0.27489 -0.07149 -0.03706 0.03063  282 HIS A CG  
1403 N ND1 . HIS A 102 ? 0.34549 0.34632 0.21513 -0.06724 -0.03591 0.02916  282 HIS A ND1 
1404 C CD2 . HIS A 102 ? 0.35473 0.34267 0.21442 -0.08238 -0.03800 0.03197  282 HIS A CD2 
1405 C CE1 . HIS A 102 ? 0.28756 0.28790 0.14605 -0.07493 -0.03577 0.02947  282 HIS A CE1 
1406 N NE2 . HIS A 102 ? 0.27548 0.26815 0.12793 -0.08469 -0.03702 0.03142  282 HIS A NE2 
1414 N N   . CYS A 103 ? 0.39551 0.41213 0.30392 -0.05145 -0.02670 0.02902  283 CYS A N   
1415 C CA  . CYS A 103 ? 0.20608 0.22418 0.12006 -0.04912 -0.02458 0.02911  283 CYS A CA  
1416 C C   . CYS A 103 ? 0.34782 0.38464 0.27000 -0.04949 -0.01630 0.02805  283 CYS A C   
1417 O O   . CYS A 103 ? 0.29807 0.33829 0.22536 -0.04641 -0.01314 0.02814  283 CYS A O   
1418 C CB  . CYS A 103 ? 0.24585 0.26013 0.16429 -0.04670 -0.03033 0.03229  283 CYS A CB  
1419 S SG  . CYS A 103 ? 0.40815 0.39839 0.32118 -0.04923 -0.04632 0.03436  283 CYS A SG  
1425 N N   . ASN A 104 ? 0.54272 0.46756 0.42390 -0.03121 -0.06497 0.03571  284 ASN A N   
1426 C CA  . ASN A 104 ? 0.45836 0.39416 0.33169 -0.02716 -0.05050 0.03399  284 ASN A CA  
1427 C C   . ASN A 104 ? 0.31097 0.23831 0.17204 -0.02733 -0.04691 0.03382  284 ASN A C   
1428 O O   . ASN A 104 ? 0.34056 0.26635 0.20097 -0.02969 -0.05038 0.03197  284 ASN A O   
1429 C CB  . ASN A 104 ? 0.59410 0.54842 0.47428 -0.02419 -0.04397 0.02995  284 ASN A CB  
1432 N N   . GLY A 105 ? 0.39535 0.31518 0.24535 -0.02468 -0.03812 0.03589  285 GLY A N   
1433 C CA  . GLY A 105 ? 0.33876 0.25021 0.17524 -0.02342 -0.03069 0.03465  285 GLY A CA  
1434 C C   . GLY A 105 ? 0.46197 0.35404 0.30221 -0.02371 -0.03556 0.03447  285 GLY A C   
1435 O O   . GLY A 105 ? 0.49013 0.37543 0.32068 -0.02247 -0.03015 0.03182  285 GLY A O   
1439 N N   . LYS A 106 ? 0.31717 0.20721 0.18513 -0.02296 -0.04348 0.03375  286 LYS A N   
1440 C CA  . LYS A 106 ? 0.26456 0.14496 0.15437 -0.02018 -0.04617 0.02978  286 LYS A CA  
1441 C C   . LYS A 106 ? 0.36759 0.24947 0.29246 -0.01384 -0.03651 0.02626  286 LYS A C   
1442 O O   . LYS A 106 ? 0.33589 0.21103 0.28068 -0.01004 -0.03552 0.02206  286 LYS A O   
1443 C CB  . LYS A 106 ? 0.28730 0.16229 0.18031 -0.02475 -0.06665 0.03145  286 LYS A CB  
1444 C CG  . LYS A 106 ? 0.46744 0.34046 0.32755 -0.03219 -0.07683 0.03517  286 LYS A CG  
1445 C CD  . LYS A 106 ? 0.45709 0.32145 0.30127 -0.03249 -0.07241 0.03274  286 LYS A CD  
1446 C CE  . LYS A 106 ? 0.56072 0.41137 0.42132 -0.03045 -0.07995 0.02944  286 LYS A CE  
1447 N NZ  . LYS A 106 ? 0.53330 0.37350 0.37019 -0.03598 -0.08818 0.03011  286 LYS A NZ  
1461 N N   . LEU A 107 ? 0.37861 0.26900 0.31211 -0.01266 -0.02939 0.02765  287 LEU A N   
1462 C CA  . LEU A 107 ? 0.33824 0.23107 0.30575 -0.00766 -0.01906 0.02451  287 LEU A CA  
1463 C C   . LEU A 107 ? 0.25501 0.14766 0.21586 -0.00329 0.00282  0.02292  287 LEU A C   
1464 O O   . LEU A 107 ? 0.31126 0.20859 0.25748 -0.00338 0.01205  0.02558  287 LEU A O   
1465 C CB  . LEU A 107 ? 0.24000 0.14048 0.22064 -0.00935 -0.02406 0.02686  287 LEU A CB  
1466 C CG  . LEU A 107 ? 0.34420 0.24391 0.33382 -0.01281 -0.04569 0.02799  287 LEU A CG  
1467 C CD1 . LEU A 107 ? 0.29746 0.20421 0.29460 -0.01445 -0.05012 0.03025  287 LEU A CD1 
1468 C CD2 . LEU A 107 ? 0.32408 0.21878 0.34591 -0.00966 -0.05168 0.02348  287 LEU A CD2 
1480 N N   . GLY A 108 ? 0.26429 0.15057 0.23463 0.00100  0.01108  0.01852  288 GLY A N   
1481 C CA  . GLY A 108 ? 0.33754 0.22188 0.29907 0.00551  0.03197  0.01685  288 GLY A CA  
1482 C C   . GLY A 108 ? 0.40555 0.28906 0.32593 0.00348  0.03448  0.01987  288 GLY A C   
1483 O O   . GLY A 108 ? 0.44945 0.33111 0.34810 -0.00083 0.02135  0.02145  288 GLY A O   
1487 N N   . SER A 109 ? 0.36879 0.25355 0.27825 0.00656  0.05155  0.02069  289 SER A N   
1488 C CA  . SER A 109 ? 0.46220 0.34752 0.33397 0.00558  0.05463  0.02350  289 SER A CA  
1489 C C   . SER A 109 ? 0.49820 0.39193 0.36209 0.00293  0.05123  0.02822  289 SER A C   
1490 O O   . SER A 109 ? 0.45372 0.34932 0.28842 0.00304  0.05477  0.03057  289 SER A O   
1491 C CB  . SER A 109 ? 0.53994 0.41935 0.39979 0.01149  0.07506  0.02145  289 SER A CB  
1492 O OG  . SER A 109 ? 0.62648 0.50741 0.50631 0.01487  0.09001  0.02169  289 SER A OG  
1498 N N   . TYR A 110 ? 0.43114 0.32973 0.32027 0.00098  0.04396  0.02928  290 TYR A N   
1499 C CA  . TYR A 110 ? 0.32929 0.23468 0.21344 -0.00076 0.04176  0.03319  290 TYR A CA  
1500 C C   . TYR A 110 ? 0.36773 0.27792 0.22423 -0.00537 0.02705  0.03641  290 TYR A C   
1501 O O   . TYR A 110 ? 0.26107 0.17016 0.11214 -0.00905 0.01394  0.03606  290 TYR A O   
1502 C CB  . TYR A 110 ? 0.24362 0.15224 0.16261 -0.00190 0.03600  0.03282  290 TYR A CB  
1503 C CG  . TYR A 110 ? 0.24750 0.15385 0.19715 0.00201  0.05111  0.02972  290 TYR A CG  
1504 C CD1 . TYR A 110 ? 0.41139 0.31594 0.35582 0.00538  0.07048  0.03048  290 TYR A CD1 
1505 C CD2 . TYR A 110 ? 0.26415 0.17013 0.24799 0.00241  0.04618  0.02604  290 TYR A CD2 
1506 C CE1 . TYR A 110 ? 0.33883 0.24172 0.31155 0.00832  0.08549  0.02784  290 TYR A CE1 
1507 C CE2 . TYR A 110 ? 0.25796 0.16369 0.27188 0.00582  0.06056  0.02288  290 TYR A CE2 
1508 C CZ  . TYR A 110 ? 0.29046 0.19488 0.29882 0.00839  0.08067  0.02389  290 TYR A CZ  
1509 O OH  . TYR A 110 ? 0.35657 0.26113 0.39513 0.01116  0.09611  0.02093  290 TYR A OH  
1519 N N   . LYS A 111 ? 0.25352 0.17002 0.09427 -0.00508 0.02937  0.03920  291 LYS A N   
1520 C CA  . LYS A 111 ? 0.33279 0.27524 0.18284 -0.00716 0.01381  0.03703  291 LYS A CA  
1521 C C   . LYS A 111 ? 0.34124 0.28587 0.19715 -0.00765 0.01044  0.03976  291 LYS A C   
1522 O O   . LYS A 111 ? 0.30515 0.25892 0.16625 -0.00534 0.01656  0.03921  291 LYS A O   
1523 C CB  . LYS A 111 ? 0.39054 0.35831 0.24997 -0.00459 0.01537  0.03323  291 LYS A CB  
1524 C CG  . LYS A 111 ? 0.36268 0.34541 0.22762 -0.00328 0.00692  0.03145  291 LYS A CG  
1525 C CD  . LYS A 111 ? 0.47768 0.46396 0.33691 -0.00286 0.00819  0.02838  291 LYS A CD  
1526 C CE  . LYS A 111 ? 0.47104 0.45635 0.32686 -0.00274 0.01578  0.02734  291 LYS A CE  
1527 N NZ  . LYS A 111 ? 0.43693 0.42756 0.28806 -0.00229 0.01499  0.02518  291 LYS A NZ  
1541 N N   . ILE A 112 ? 0.29362 0.22940 0.14981 -0.01188 -0.00186 0.04245  292 ILE A N   
1542 C CA  . ILE A 112 ? 0.23181 0.16468 0.09323 -0.01354 -0.00735 0.04572  292 ILE A CA  
1543 C C   . ILE A 112 ? 0.33259 0.29113 0.20531 -0.00935 -0.01197 0.04026  292 ILE A C   
1544 O O   . ILE A 112 ? 0.37383 0.34157 0.25256 -0.00869 -0.01824 0.03623  292 ILE A O   
1545 C CB  . ILE A 112 ? 0.35822 0.28738 0.24803 -0.01601 -0.01930 0.04438  292 ILE A CB  
1546 C CG1 . ILE A 112 ? 0.28568 0.20938 0.20234 -0.01300 -0.00888 0.04060  292 ILE A CG1 
1547 C CG2 . ILE A 112 ? 0.38457 0.31644 0.28913 -0.01659 -0.02586 0.04521  292 ILE A CG2 
1548 C CD1 . ILE A 112 ? 0.35943 0.28080 0.30636 -0.01423 -0.02086 0.03805  292 ILE A CD1 
1560 N N   . ASN A 113 ? 0.40540 0.37197 0.28143 -0.00564 -0.00645 0.04049  293 ASN A N   
1561 C CA  . ASN A 113 ? 0.36523 0.34831 0.24865 -0.00055 -0.00843 0.03624  293 ASN A CA  
1562 C C   . ASN A 113 ? 0.34065 0.32254 0.22758 -0.00004 -0.01134 0.03741  293 ASN A C   
1563 O O   . ASN A 113 ? 0.31172 0.29691 0.19732 0.00001  -0.01450 0.03415  293 ASN A O   
1564 C CB  . ASN A 113 ? 0.31660 0.30813 0.19690 0.00105  -0.00183 0.03462  293 ASN A CB  
1565 C CG  . ASN A 113 ? 0.49128 0.48398 0.37337 -0.00134 0.00523  0.03710  293 ASN A CG  
1566 O OD1 . ASN A 113 ? 0.41692 0.39851 0.29762 -0.00313 0.00883  0.04127  293 ASN A OD1 
1567 N ND2 . ASN A 113 ? 0.58696 0.58239 0.46492 -0.00246 0.00772  0.03447  293 ASN A ND2 
1574 N N   . GLY A 114 ? 0.27134 0.23375 0.15223 -0.00639 -0.01370 0.04298  294 GLY A N   
1575 C CA  . GLY A 114 ? 0.41471 0.37219 0.29747 -0.00756 -0.01832 0.04484  294 GLY A CA  
1576 C C   . GLY A 114 ? 0.30277 0.24090 0.19666 -0.01303 -0.02254 0.05029  294 GLY A C   
1577 O O   . GLY A 114 ? 0.25807 0.19356 0.16969 -0.01312 -0.01733 0.04822  294 GLY A O   
1582 N N   . ARG A 115 ? 0.21199 0.14912 0.11863 -0.01324 -0.02751 0.05001  295 ARG A N   
1583 C CA  . ARG A 115 ? 0.20580 0.13959 0.15039 -0.01424 -0.02799 0.04718  295 ARG A CA  
1584 C C   . ARG A 115 ? 0.21946 0.15081 0.16995 -0.01349 -0.02597 0.04742  295 ARG A C   
1585 O O   . ARG A 115 ? 0.27827 0.21040 0.20341 -0.01212 -0.02824 0.04961  295 ARG A O   
1586 C CB  . ARG A 115 ? 0.19760 0.13230 0.15894 -0.01728 -0.04665 0.04535  295 ARG A CB  
1587 C CG  . ARG A 115 ? 0.21697 0.15389 0.15805 -0.01893 -0.06373 0.04711  295 ARG A CG  
1588 C CD  . ARG A 115 ? 0.28046 0.21549 0.24485 -0.02115 -0.08121 0.04487  295 ARG A CD  
1589 N NE  . ARG A 115 ? 0.20678 0.14639 0.15592 -0.02216 -0.08855 0.04188  295 ARG A NE  
1590 C CZ  . ARG A 115 ? 0.30411 0.24623 0.24874 -0.02075 -0.08638 0.03955  295 ARG A CZ  
1591 N NH1 . ARG A 115 ? 0.27409 0.21059 0.22016 -0.01966 -0.08693 0.04388  295 ARG A NH1 
1592 N NH2 . ARG A 115 ? 0.37364 0.32279 0.31320 -0.01945 -0.08278 0.03425  295 ARG A NH2 
1606 N N   . THR A 116 ? 0.21801 0.14645 0.20302 -0.01440 -0.02174 0.04489  296 THR A N   
1607 C CA  . THR A 116 ? 0.23982 0.16498 0.23573 -0.01484 -0.02249 0.04449  296 THR A CA  
1608 C C   . THR A 116 ? 0.21566 0.14217 0.21281 -0.01671 -0.04402 0.04347  296 THR A C   
1609 O O   . THR A 116 ? 0.21510 0.14467 0.20738 -0.01792 -0.05773 0.04320  296 THR A O   
1610 C CB  . THR A 116 ? 0.20795 0.13066 0.24349 -0.01626 -0.01253 0.04171  296 THR A CB  
1611 O OG1 . THR A 116 ? 0.21619 0.14230 0.28200 -0.01834 -0.02391 0.03814  296 THR A OG1 
1612 C CG2 . THR A 116 ? 0.21926 0.13973 0.25321 -0.01429 0.00968  0.04273  296 THR A CG2 
1620 N N   . LYS A 117 ? 0.25358 0.17650 0.25609 -0.01694 -0.04697 0.04292  297 LYS A N   
1621 C CA  . LYS A 117 ? 0.27699 0.19964 0.28799 -0.01871 -0.06693 0.04091  297 LYS A CA  
1622 C C   . LYS A 117 ? 0.30358 0.22704 0.35548 -0.02130 -0.07379 0.03691  297 LYS A C   
1623 O O   . LYS A 117 ? 0.20252 0.12710 0.27782 -0.02168 -0.06171 0.03555  297 LYS A O   
1624 C CB  . LYS A 117 ? 0.35185 0.26924 0.35953 -0.01814 -0.06801 0.04073  297 LYS A CB  
1625 C CG  . LYS A 117 ? 0.26793 0.18474 0.23493 -0.01465 -0.06461 0.04410  297 LYS A CG  
1626 C CD  . LYS A 117 ? 0.24309 0.15304 0.20823 -0.01368 -0.06655 0.04343  297 LYS A CD  
1627 C CE  . LYS A 117 ? 0.50998 0.41905 0.43619 -0.00911 -0.06102 0.04650  297 LYS A CE  
1628 N NZ  . LYS A 117 ? 0.59727 0.49752 0.52203 -0.00763 -0.06058 0.04582  297 LYS A NZ  
1642 N N   . ALA A 118 ? 0.23561 0.15850 0.29588 -0.02265 -0.09360 0.03477  298 ALA A N   
1643 C CA  . ALA A 118 ? 0.20260 0.12649 0.30114 -0.02444 -0.10300 0.03058  298 ALA A CA  
1644 C C   . ALA A 118 ? 0.31609 0.23809 0.44879 -0.02615 -0.09892 0.02721  298 ALA A C   
1645 O O   . ALA A 118 ? 0.32249 0.24034 0.44987 -0.02665 -0.10465 0.02685  298 ALA A O   
1646 C CB  . ALA A 118 ? 0.20396 0.12677 0.29599 -0.02490 -0.12668 0.02970  298 ALA A CB  
1652 N N   . MET A 119 ? 0.23272 0.15773 0.40062 -0.02717 -0.08881 0.02456  299 MET A N   
1653 C CA  . MET A 119 ? 0.20880 0.13352 0.41470 -0.02977 -0.08482 0.02093  299 MET A CA  
1654 C C   . MET A 119 ? 0.36030 0.28854 0.59705 -0.03036 -0.10454 0.01585  299 MET A C   
1655 O O   . MET A 119 ? 0.26676 0.20142 0.52238 -0.02845 -0.10609 0.01360  299 MET A O   
1656 C CB  . MET A 119 ? 0.35117 0.27873 0.57883 -0.03029 -0.06182 0.02066  299 MET A CB  
1657 C CG  . MET A 119 ? 0.30147 0.23024 0.57286 -0.03390 -0.05644 0.01672  299 MET A CG  
1658 S SD  . MET A 119 ? 0.29252 0.22419 0.58615 -0.03467 -0.02684 0.01699  299 MET A SD  
1659 C CE  . MET A 119 ? 0.40398 0.34819 0.73682 -0.03267 -0.03334 0.01113  299 MET A CE  
1669 N N   . VAL A 120 ? 0.38265 0.31009 0.61695 -0.02948 -0.11759 0.01429  300 VAL A N   
1670 C CA  . VAL A 120 ? 0.24879 0.18166 0.50567 -0.02554 -0.13185 0.01029  300 VAL A CA  
1671 C C   . VAL A 120 ? 0.21656 0.15543 0.51266 -0.02696 -0.12108 0.00643  300 VAL A C   
1672 O O   . VAL A 120 ? 0.27908 0.21475 0.57569 -0.02980 -0.11475 0.00642  300 VAL A O   
1673 C CB  . VAL A 120 ? 0.33896 0.26469 0.57224 -0.02270 -0.14875 0.01113  300 VAL A CB  
1674 C CG1 . VAL A 120 ? 0.34218 0.26694 0.59467 -0.01754 -0.16132 0.00798  300 VAL A CG1 
1675 C CG2 . VAL A 120 ? 0.41904 0.33775 0.60937 -0.02159 -0.15523 0.01559  300 VAL A CG2 
1685 N N   . ALA A 121 ? 0.26674 0.21357 0.59506 -0.02492 -0.11875 0.00318  301 ALA A N   
1686 C CA  . ALA A 121 ? 0.23191 0.18578 0.59932 -0.02629 -0.10640 -0.00049 301 ALA A CA  
1687 C C   . ALA A 121 ? 0.30791 0.26605 0.70400 -0.02167 -0.12062 -0.00518 301 ALA A C   
1688 O O   . ALA A 121 ? 0.23210 0.18881 0.62583 -0.01683 -0.13376 -0.00578 301 ALA A O   
1689 C CB  . ALA A 121 ? 0.39147 0.35021 0.77414 -0.02759 -0.08700 -0.00041 301 ALA A CB  
1695 N N   . CYS A 122 ? 0.30314 0.26411 0.72470 -0.02309 -0.11760 -0.00828 302 CYS A N   
1696 C CA  . CYS A 122 ? 0.26989 0.23337 0.72101 -0.01899 -0.12955 -0.01309 302 CYS A CA  
1697 C C   . CYS A 122 ? 0.31868 0.29106 0.81147 -0.02138 -0.11424 -0.01700 302 CYS A C   
1698 O O   . CYS A 122 ? 0.31176 0.28451 0.80819 -0.02654 -0.10142 -0.01635 302 CYS A O   
1699 C CB  . CYS A 122 ? 0.38631 0.34223 0.82474 -0.01790 -0.14523 -0.01335 302 CYS A CB  
1700 S SG  . CYS A 122 ? 0.31610 0.27369 0.79424 -0.01455 -0.15600 -0.01969 302 CYS A SG  
1706 N N   . TYR A 123 ? 0.24248 0.22041 0.76539 -0.01758 -0.11516 -0.02102 303 TYR A N   
1707 C CA  . TYR A 123 ? 0.24829 0.23398 0.81410 -0.01866 -0.10453 -0.02587 303 TYR A CA  
1708 C C   . TYR A 123 ? 0.25994 0.24317 0.84291 -0.01565 -0.12225 -0.03017 303 TYR A C   
1709 O O   . TYR A 123 ? 0.26437 0.24350 0.84986 -0.00991 -0.13797 -0.03241 303 TYR A O   
1710 C CB  . TYR A 123 ? 0.25708 0.24897 0.84681 -0.01595 -0.09556 -0.02859 303 TYR A CB  
1711 C CG  . TYR A 123 ? 0.23581 0.22969 0.81136 -0.01878 -0.07619 -0.02476 303 TYR A CG  
1712 C CD1 . TYR A 123 ? 0.22769 0.21703 0.77010 -0.01761 -0.08149 -0.02071 303 TYR A CD1 
1713 C CD2 . TYR A 123 ? 0.24315 0.24197 0.83705 -0.02258 -0.05210 -0.02509 303 TYR A CD2 
1714 C CE1 . TYR A 123 ? 0.22066 0.21034 0.74922 -0.02023 -0.06386 -0.01733 303 TYR A CE1 
1715 C CE2 . TYR A 123 ? 0.23101 0.22916 0.80940 -0.02459 -0.03354 -0.02138 303 TYR A CE2 
1716 C CZ  . TYR A 123 ? 0.31458 0.30814 0.86071 -0.02342 -0.03974 -0.01762 303 TYR A CZ  
1717 O OH  . TYR A 123 ? 0.38120 0.37248 0.91065 -0.02530 -0.02132 -0.01396 303 TYR A OH  
1727 N N   . PRO A 124 ? 0.28527 0.26888 0.87862 -0.01942 -0.12064 -0.03141 304 PRO A N   
1728 C CA  . PRO A 124 ? 0.27927 0.25893 0.88421 -0.01677 -0.13876 -0.03516 304 PRO A CA  
1729 C C   . PRO A 124 ? 0.32334 0.30915 0.97392 -0.01485 -0.13882 -0.04189 304 PRO A C   
1730 O O   . PRO A 124 ? 0.33914 0.32690 1.01280 -0.01702 -0.14047 -0.04542 304 PRO A O   
1731 C CB  . PRO A 124 ? 0.28303 0.26036 0.87863 -0.02250 -0.13522 -0.03353 304 PRO A CB  
1732 C CG  . PRO A 124 ? 0.27755 0.26036 0.87885 -0.02863 -0.11055 -0.03148 304 PRO A CG  
1733 C CD  . PRO A 124 ? 0.26624 0.25163 0.85777 -0.02656 -0.10190 -0.02910 304 PRO A CD  
1741 N N   . GLY A 125 ? 0.28589 0.27423 0.94962 -0.01096 -0.13731 -0.04400 305 GLY A N   
1742 C CA  . GLY A 125 ? 0.29546 0.28883 1.00200 -0.00906 -0.13742 -0.05095 305 GLY A CA  
1743 C C   . GLY A 125 ? 0.29802 0.30144 1.03593 -0.01494 -0.11724 -0.05312 305 GLY A C   
1744 O O   . GLY A 125 ? 0.29329 0.30016 1.02231 -0.01961 -0.09806 -0.04927 305 GLY A O   
1748 N N   . ASN A 126 ? 0.39093 0.39794 1.16515 -0.01495 -0.12126 -0.05935 306 ASN A N   
1749 C CA  . ASN A 126 ? 0.31696 0.33264 1.12306 -0.02092 -0.10367 -0.06190 306 ASN A CA  
1750 C C   . ASN A 126 ? 0.38388 0.40658 1.20334 -0.02283 -0.07951 -0.06166 306 ASN A C   
1751 O O   . ASN A 126 ? 0.38916 0.41662 1.22130 -0.02873 -0.05982 -0.06099 306 ASN A O   
1752 C CB  . ASN A 126 ? 0.32596 0.33929 1.11470 -0.02721 -0.09904 -0.05775 306 ASN A CB  
1753 C CG  . ASN A 126 ? 0.32503 0.33115 1.10254 -0.02571 -0.12163 -0.05853 306 ASN A CG  
1754 O OD1 . ASN A 126 ? 0.32726 0.32627 1.07010 -0.02703 -0.12696 -0.05374 306 ASN A OD1 
1755 N ND2 . ASN A 126 ? 0.33727 0.34446 1.14364 -0.02292 -0.13482 -0.06482 306 ASN A ND2 
1762 N N   . GLY A 127 ? 0.30550 0.32757 1.12090 -0.01804 -0.08024 -0.06212 307 GLY A N   
1763 C CA  . GLY A 127 ? 0.30180 0.32931 1.12822 -0.01923 -0.05789 -0.06215 307 GLY A CA  
1764 C C   . GLY A 127 ? 0.29059 0.31617 1.08467 -0.02232 -0.04137 -0.05486 307 GLY A C   
1765 O O   . GLY A 127 ? 0.28941 0.31827 1.09021 -0.02370 -0.02027 -0.05436 307 GLY A O   
1769 N N   . THR A 128 ? 0.28392 0.30342 1.04209 -0.02350 -0.04996 -0.04934 308 THR A N   
1770 C CA  . THR A 128 ? 0.27450 0.29103 0.99975 -0.02669 -0.03527 -0.04253 308 THR A CA  
1771 C C   . THR A 128 ? 0.31431 0.33027 1.02539 -0.02271 -0.03298 -0.04097 308 THR A C   
1772 O O   . THR A 128 ? 0.30733 0.32174 1.01858 -0.01734 -0.05013 -0.04324 308 THR A O   
1773 C CB  . THR A 128 ? 0.27089 0.28013 0.96003 -0.02878 -0.04727 -0.03767 308 THR A CB  
1774 O OG1 . THR A 128 ? 0.35016 0.35483 1.01766 -0.02351 -0.06881 -0.03688 308 THR A OG1 
1775 C CG2 . THR A 128 ? 0.28188 0.29043 0.98449 -0.03219 -0.05377 -0.03982 308 THR A CG2 
1783 N N   . GLY A 129 ? 0.43526 0.45093 1.13247 -0.02542 -0.01154 -0.03695 309 GLY A N   
1784 C CA  . GLY A 129 ? 0.25413 0.26912 0.93728 -0.02242 -0.00700 -0.03524 309 GLY A CA  
1785 C C   . GLY A 129 ? 0.27011 0.28123 0.92471 -0.02614 0.01383  -0.02899 309 GLY A C   
1786 O O   . GLY A 129 ? 0.24900 0.25537 0.88392 -0.03062 0.01895  -0.02488 309 GLY A O   
1790 N N   . TYR A 130 ? 0.24315 0.25471 0.89434 -0.02405 0.02582  -0.02842 310 TYR A N   
1791 C CA  . TYR A 130 ? 0.24117 0.24733 0.86330 -0.02651 0.04640  -0.02258 310 TYR A CA  
1792 C C   . TYR A 130 ? 0.26235 0.27095 0.90280 -0.02462 0.06772  -0.02496 310 TYR A C   
1793 O O   . TYR A 130 ? 0.29591 0.30778 0.94917 -0.02058 0.06223  -0.02846 310 TYR A O   
1794 C CB  . TYR A 130 ? 0.26328 0.26406 0.84728 -0.02579 0.03531  -0.01792 310 TYR A CB  
1795 C CG  . TYR A 130 ? 0.25295 0.24433 0.79767 -0.02919 0.05103  -0.01087 310 TYR A CG  
1796 C CD1 . TYR A 130 ? 0.23787 0.22646 0.78076 -0.03003 0.07819  -0.00898 310 TYR A CD1 
1797 C CD2 . TYR A 130 ? 0.22457 0.20790 0.73134 -0.03088 0.03855  -0.00614 310 TYR A CD2 
1798 C CE1 . TYR A 130 ? 0.24064 0.21854 0.74452 -0.03193 0.09203  -0.00240 310 TYR A CE1 
1799 C CE2 . TYR A 130 ? 0.22674 0.19943 0.69626 -0.03314 0.05235  0.00017  310 TYR A CE2 
1800 C CZ  . TYR A 130 ? 0.34224 0.31222 0.81020 -0.03342 0.07888  0.00212  310 TYR A CZ  
1801 O OH  . TYR A 130 ? 0.23926 0.19736 0.66746 -0.03438 0.09213  0.00853  310 TYR A OH  
1811 N N   . VAL A 131 ? 0.25744 0.26289 0.89684 -0.02744 0.09177  -0.02307 311 VAL A N   
1812 C CA  . VAL A 131 ? 0.26652 0.27238 0.91993 -0.02573 0.11316  -0.02527 311 VAL A CA  
1813 C C   . VAL A 131 ? 0.25950 0.26158 0.88726 -0.02275 0.11897  -0.02237 311 VAL A C   
1814 O O   . VAL A 131 ? 0.24964 0.24749 0.84488 -0.02314 0.11134  -0.01745 311 VAL A O   
1815 C CB  . VAL A 131 ? 0.38876 0.38932 1.03897 -0.02926 0.13746  -0.02295 311 VAL A CB  
1816 C CG1 . VAL A 131 ? 0.28798 0.29102 0.95558 -0.03339 0.13041  -0.02428 311 VAL A CG1 
1817 C CG2 . VAL A 131 ? 0.33424 0.32372 0.93858 -0.03006 0.15135  -0.01534 311 VAL A CG2 
1827 N N   . ARG A 132 ? 0.26661 0.26974 0.90841 -0.02017 0.13249  -0.02556 312 ARG A N   
1828 C CA  . ARG A 132 ? 0.26266 0.26229 0.88192 -0.01712 0.13992  -0.02340 312 ARG A CA  
1829 C C   . ARG A 132 ? 0.32852 0.31780 0.90298 -0.01843 0.15433  -0.01567 312 ARG A C   
1830 O O   . ARG A 132 ? 0.27756 0.26018 0.84185 -0.02046 0.17131  -0.01310 312 ARG A O   
1831 C CB  . ARG A 132 ? 0.28604 0.28682 0.92382 -0.01498 0.15603  -0.02769 312 ARG A CB  
1832 C CG  . ARG A 132 ? 0.27175 0.27218 0.89585 -0.01076 0.15777  -0.02789 312 ARG A CG  
1833 C CD  . ARG A 132 ? 0.42227 0.41835 1.04126 -0.00947 0.18237  -0.02833 312 ARG A CD  
1834 N NE  . ARG A 132 ? 0.49162 0.49057 1.10920 -0.00470 0.18154  -0.03114 312 ARG A NE  
1835 C CZ  . ARG A 132 ? 0.61768 0.60957 1.20478 -0.00156 0.19716  -0.02850 312 ARG A CZ  
1836 N NH1 . ARG A 132 ? 0.68873 0.66901 1.24218 -0.00277 0.21468  -0.02271 312 ARG A NH1 
1837 N NH2 . ARG A 132 ? 0.63019 0.62555 1.21827 0.00354  0.19393  -0.03196 312 ARG A NH2 
1851 N N   . HIS A 133 ? 0.36373 0.35067 0.91010 -0.01732 0.14698  -0.01195 313 HIS A N   
1852 C CA  . HIS A 133 ? 0.34564 0.32166 0.84604 -0.01867 0.15674  -0.00447 313 HIS A CA  
1853 C C   . HIS A 133 ? 0.30491 0.27866 0.77945 -0.01695 0.15175  -0.00165 313 HIS A C   
1854 O O   . HIS A 133 ? 0.23706 0.21628 0.72311 -0.01368 0.13542  -0.00562 313 HIS A O   
1855 C CB  . HIS A 133 ? 0.26273 0.23568 0.75072 -0.02308 0.14487  -0.00112 313 HIS A CB  
1856 C CG  . HIS A 133 ? 0.23647 0.21232 0.72302 -0.02445 0.11706  -0.00141 313 HIS A CG  
1857 N ND1 . HIS A 133 ? 0.23066 0.21653 0.75252 -0.02370 0.09752  -0.00734 313 HIS A ND1 
1858 C CD2 . HIS A 133 ? 0.22983 0.19731 0.67988 -0.02571 0.10461  0.00335  313 HIS A CD2 
1859 C CE1 . HIS A 133 ? 0.23235 0.21607 0.73813 -0.02429 0.07411  -0.00612 313 HIS A CE1 
1860 N NE2 . HIS A 133 ? 0.23899 0.21119 0.70142 -0.02573 0.07797  0.00024  313 HIS A NE2 
1868 N N   . VAL A 134 ? 0.32664 0.28859 0.75447 -0.01621 0.16249  0.00458  314 VAL A N   
1869 C CA  . VAL A 134 ? 0.36817 0.32276 0.75056 -0.01146 0.15350  0.00713  314 VAL A CA  
1870 C C   . VAL A 134 ? 0.33497 0.28169 0.68038 -0.01395 0.14158  0.01267  314 VAL A C   
1871 O O   . VAL A 134 ? 0.30076 0.24181 0.63677 -0.01715 0.15252  0.01653  314 VAL A O   
1872 C CB  . VAL A 134 ? 0.32287 0.27057 0.67910 -0.00684 0.17617  0.00880  314 VAL A CB  
1873 C CG1 . VAL A 134 ? 0.29569 0.23471 0.60058 -0.00326 0.16708  0.01228  314 VAL A CG1 
1874 C CG2 . VAL A 134 ? 0.27116 0.22655 0.66042 -0.00302 0.18525  0.00266  314 VAL A CG2 
1884 N N   . ASP A 135 ? 0.26104 0.20703 0.58525 -0.01239 0.11938  0.01306  315 ASP A N   
1885 C CA  . ASP A 135 ? 0.29419 0.23461 0.58642 -0.01451 0.10620  0.01758  315 ASP A CA  
1886 C C   . ASP A 135 ? 0.37039 0.30082 0.61691 -0.01278 0.12087  0.02330  315 ASP A C   
1887 O O   . ASP A 135 ? 0.28299 0.20811 0.51373 -0.01507 0.12234  0.02708  315 ASP A O   
1888 C CB  . ASP A 135 ? 0.22417 0.16622 0.50340 -0.01327 0.08060  0.01678  315 ASP A CB  
1889 C CG  . ASP A 135 ? 0.29895 0.24801 0.61499 -0.01585 0.06081  0.01265  315 ASP A CG  
1890 O OD1 . ASP A 135 ? 0.25228 0.20608 0.60574 -0.01881 0.06658  0.01000  315 ASP A OD1 
1891 O OD2 . ASP A 135 ? 0.21115 0.16060 0.51845 -0.01509 0.03935  0.01204  315 ASP A OD2 
1896 N N   . ASN A 136 ? 0.32090 0.24801 0.54503 -0.00837 0.13106  0.02376  316 ASN A N   
1897 C CA  . ASN A 136 ? 0.30820 0.22578 0.48763 -0.00583 0.14403  0.02868  316 ASN A CA  
1898 C C   . ASN A 136 ? 0.32690 0.24116 0.50717 -0.00235 0.16756  0.02765  316 ASN A C   
1899 O O   . ASN A 136 ? 0.28584 0.19841 0.44785 0.00178  0.16835  0.02652  316 ASN A O   
1900 C CB  . ASN A 136 ? 0.25062 0.16643 0.39059 -0.00368 0.12829  0.03064  316 ASN A CB  
1901 C CG  . ASN A 136 ? 0.31481 0.22198 0.40992 -0.00032 0.14089  0.03486  316 ASN A CG  
1902 O OD1 . ASN A 136 ? 0.27125 0.17193 0.36006 0.00023  0.15934  0.03735  316 ASN A OD1 
1903 N ND2 . ASN A 136 ? 0.27044 0.17709 0.33390 0.00184  0.13069  0.03568  316 ASN A ND2 
1910 N N   . PRO A 137 ? 0.34961 0.26218 0.55007 -0.00407 0.18740  0.02797  317 PRO A N   
1911 C CA  . PRO A 137 ? 0.43294 0.34133 0.63234 0.00003  0.20847  0.02625  317 PRO A CA  
1912 C C   . PRO A 137 ? 0.41014 0.30386 0.55592 0.00521  0.21352  0.02909  317 PRO A C   
1913 O O   . PRO A 137 ? 0.51347 0.40139 0.64370 0.00951  0.21984  0.02746  317 PRO A O   
1914 C CB  . PRO A 137 ? 0.30020 0.20967 0.53366 -0.00241 0.21684  0.02359  317 PRO A CB  
1915 C CG  . PRO A 137 ? 0.39511 0.30469 0.62957 -0.00712 0.20852  0.02660  317 PRO A CG  
1916 C CD  . PRO A 137 ? 0.39344 0.30751 0.62015 -0.00963 0.18869  0.02877  317 PRO A CD  
1924 N N   . ASN A 138 ? 0.42271 0.31046 0.54103 0.00478  0.20852  0.03293  318 ASN A N   
1925 C CA  . ASN A 138 ? 0.45774 0.33301 0.53044 0.00961  0.20967  0.03476  318 ASN A CA  
1926 C C   . ASN A 138 ? 0.41016 0.28607 0.44660 0.01133  0.19503  0.03713  318 ASN A C   
1927 O O   . ASN A 138 ? 0.36399 0.23404 0.37086 0.01351  0.18996  0.03884  318 ASN A O   
1928 C CB  . ASN A 138 ? 0.47973 0.34693 0.55037 0.00889  0.21634  0.03617  318 ASN A CB  
1929 C CG  . ASN A 138 ? 0.53275 0.40030 0.64093 0.00628  0.22999  0.03377  318 ASN A CG  
1930 O OD1 . ASN A 138 ? 0.57857 0.45498 0.72037 0.00454  0.23242  0.03063  318 ASN A OD1 
1931 N ND2 . ASN A 138 ? 0.64384 0.50214 0.74732 0.00607  0.23842  0.03493  318 ASN A ND2 
1938 N N   . GLY A 139 ? 0.31203 0.19567 0.35197 0.01023  0.18740  0.03701  319 GLY A N   
1939 C CA  . GLY A 139 ? 0.36523 0.24937 0.36883 0.01221  0.17369  0.03849  319 GLY A CA  
1940 C C   . GLY A 139 ? 0.34560 0.23051 0.33029 0.01097  0.16200  0.04155  319 GLY A C   
1941 O O   . GLY A 139 ? 0.34499 0.22823 0.29745 0.01451  0.15333  0.04103  319 GLY A O   
1945 N N   . ASP A 140 ? 0.35544 0.24370 0.36343 0.00541  0.15962  0.04444  320 ASP A N   
1946 C CA  . ASP A 140 ? 0.35686 0.24486 0.34671 0.00421  0.14778  0.04757  320 ASP A CA  
1947 C C   . ASP A 140 ? 0.32301 0.21661 0.29450 0.00360  0.12920  0.04867  320 ASP A C   
1948 O O   . ASP A 140 ? 0.31601 0.21145 0.27761 0.00232  0.11612  0.05033  320 ASP A O   
1949 C CB  . ASP A 140 ? 0.29722 0.18526 0.31970 -0.00131 0.14721  0.04862  320 ASP A CB  
1950 C CG  . ASP A 140 ? 0.31208 0.21044 0.37081 -0.00486 0.13084  0.04417  320 ASP A CG  
1951 O OD1 . ASP A 140 ? 0.31243 0.21608 0.36862 -0.00364 0.12115  0.04195  320 ASP A OD1 
1952 O OD2 . ASP A 140 ? 0.30520 0.20564 0.39496 -0.00888 0.12722  0.04280  320 ASP A OD2 
1957 N N   . GLY A 141 ? 0.32829 0.22533 0.29508 0.00492  0.12533  0.04640  321 GLY A N   
1958 C CA  . GLY A 141 ? 0.27135 0.17404 0.21838 0.00452  0.10679  0.04633  321 GLY A CA  
1959 C C   . GLY A 141 ? 0.24874 0.15856 0.22268 0.00101  0.08943  0.04315  321 GLY A C   
1960 O O   . GLY A 141 ? 0.23751 0.15075 0.19693 0.00048  0.07629  0.04274  321 GLY A O   
1964 N N   . ARG A 142 ? 0.29337 0.20518 0.30582 -0.00148 0.08874  0.04088  322 ARG A N   
1965 C CA  . ARG A 142 ? 0.23022 0.14798 0.26885 -0.00413 0.07132  0.03766  322 ARG A CA  
1966 C C   . ARG A 142 ? 0.23233 0.15041 0.28086 -0.00230 0.07421  0.03430  322 ARG A C   
1967 O O   . ARG A 142 ? 0.23977 0.15545 0.30165 -0.00007 0.09169  0.03254  322 ARG A O   
1968 C CB  . ARG A 142 ? 0.23254 0.15268 0.31085 -0.00695 0.06979  0.03564  322 ARG A CB  
1969 C CG  . ARG A 142 ? 0.22643 0.14501 0.29693 -0.00890 0.06544  0.03839  322 ARG A CG  
1970 C CD  . ARG A 142 ? 0.22460 0.14533 0.33623 -0.01224 0.06314  0.03578  322 ARG A CD  
1971 N NE  . ARG A 142 ? 0.28220 0.19838 0.40511 -0.01262 0.08401  0.03668  322 ARG A NE  
1972 C CZ  . ARG A 142 ? 0.23451 0.15186 0.39305 -0.01608 0.08675  0.03469  322 ARG A CZ  
1973 N NH1 . ARG A 142 ? 0.22686 0.15005 0.41420 -0.01894 0.06932  0.03128  322 ARG A NH1 
1974 N NH2 . ARG A 142 ? 0.26470 0.17679 0.42985 -0.01685 0.10736  0.03616  322 ARG A NH2 
1988 N N   . CYS A 143 ? 0.22719 0.14746 0.26843 -0.00318 0.05734  0.03342  323 CYS A N   
1989 C CA  . CYS A 143 ? 0.25747 0.17672 0.30666 -0.00139 0.05735  0.03007  323 CYS A CA  
1990 C C   . CYS A 143 ? 0.29218 0.21471 0.37097 -0.00301 0.04003  0.02679  323 CYS A C   
1991 O O   . CYS A 143 ? 0.23878 0.16068 0.33769 -0.00081 0.04273  0.02291  323 CYS A O   
1992 C CB  . CYS A 143 ? 0.23290 0.14924 0.24279 -0.00061 0.05415  0.03181  323 CYS A CB  
1993 S SG  . CYS A 143 ? 0.28775 0.20733 0.27472 -0.00482 0.02952  0.03461  323 CYS A SG  
1999 N N   . VAL A 144 ? 0.24090 0.16624 0.32212 -0.00623 0.02221  0.02805  324 VAL A N   
2000 C CA  . VAL A 144 ? 0.21323 0.14052 0.32080 -0.00746 0.00419  0.02516  324 VAL A CA  
2001 C C   . VAL A 144 ? 0.20822 0.13912 0.33756 -0.00984 -0.00350 0.02497  324 VAL A C   
2002 O O   . VAL A 144 ? 0.22227 0.15316 0.33137 -0.01176 -0.00693 0.02837  324 VAL A O   
2003 C CB  . VAL A 144 ? 0.21227 0.13715 0.29476 -0.00923 -0.01437 0.02691  324 VAL A CB  
2004 C CG1 . VAL A 144 ? 0.28858 0.21393 0.39546 -0.01045 -0.03453 0.02464  324 VAL A CG1 
2005 C CG2 . VAL A 144 ? 0.22559 0.14609 0.29151 -0.00723 -0.00837 0.02615  324 VAL A CG2 
2015 N N   . THR A 145 ? 0.20826 0.14230 0.37898 -0.00947 -0.00666 0.02060  325 THR A N   
2016 C CA  . THR A 145 ? 0.20334 0.14069 0.39893 -0.01188 -0.01755 0.01932  325 THR A CA  
2017 C C   . THR A 145 ? 0.25848 0.19529 0.46054 -0.01243 -0.04210 0.01778  325 THR A C   
2018 O O   . THR A 145 ? 0.21073 0.14695 0.42712 -0.01016 -0.04687 0.01474  325 THR A O   
2019 C CB  . THR A 145 ? 0.20436 0.14651 0.44420 -0.01144 -0.00529 0.01512  325 THR A CB  
2020 O OG1 . THR A 145 ? 0.20855 0.14942 0.44002 -0.01100 0.01860  0.01705  325 THR A OG1 
2021 C CG2 . THR A 145 ? 0.20100 0.14642 0.46682 -0.01443 -0.01749 0.01343  325 THR A CG2 
2029 N N   . CYS A 146 ? 0.19908 0.13503 0.38920 -0.01502 -0.05754 0.01985  326 CYS A N   
2030 C CA  . CYS A 146 ? 0.19942 0.13318 0.39027 -0.01574 -0.08158 0.01917  326 CYS A CA  
2031 C C   . CYS A 146 ? 0.21338 0.14937 0.42989 -0.01726 -0.09295 0.01682  326 CYS A C   
2032 O O   . CYS A 146 ? 0.23678 0.17306 0.44342 -0.01919 -0.09003 0.01879  326 CYS A O   
2033 C CB  . CYS A 146 ? 0.30679 0.23644 0.45231 -0.01750 -0.09077 0.02419  326 CYS A CB  
2034 S SG  . CYS A 146 ? 0.30050 0.22530 0.44053 -0.01883 -0.11951 0.02443  326 CYS A SG  
2040 N N   . ILE A 147 ? 0.19938 0.13642 0.44849 -0.01606 -0.10644 0.01234  327 ILE A N   
2041 C CA  . ILE A 147 ? 0.21470 0.15443 0.49443 -0.01721 -0.11775 0.00885  327 ILE A CA  
2042 C C   . ILE A 147 ? 0.23016 0.16802 0.50342 -0.01326 -0.14069 0.00861  327 ILE A C   
2043 O O   . ILE A 147 ? 0.22087 0.15584 0.49556 -0.01051 -0.14724 0.00776  327 ILE A O   
2044 C CB  . ILE A 147 ? 0.19807 0.14640 0.52538 -0.01552 -0.10603 0.00340  327 ILE A CB  
2045 C CG1 . ILE A 147 ? 0.21843 0.16827 0.54423 -0.01650 -0.07891 0.00489  327 ILE A CG1 
2046 C CG2 . ILE A 147 ? 0.19958 0.15466 0.54906 -0.01413 -0.11386 0.00074  327 ILE A CG2 
2047 C CD1 . ILE A 147 ? 0.20789 0.16554 0.58053 -0.01582 -0.06508 -0.00022 327 ILE A CD1 
2059 N N   . TYR A 148 ? 0.20900 0.14344 0.47107 -0.01178 -0.15049 0.00997  328 TYR A N   
2060 C CA  . TYR A 148 ? 0.22236 0.14379 0.47231 -0.00760 -0.16553 0.01009  328 TYR A CA  
2061 C C   . TYR A 148 ? 0.28713 0.20984 0.56801 -0.00450 -0.16964 0.00577  328 TYR A C   
2062 O O   . TYR A 148 ? 0.29942 0.22699 0.58548 -0.00603 -0.16607 0.00566  328 TYR A O   
2063 C CB  . TYR A 148 ? 0.29636 0.20579 0.49835 -0.01030 -0.16933 0.01465  328 TYR A CB  
2064 C CG  . TYR A 148 ? 0.24418 0.13849 0.43053 -0.00905 -0.17943 0.01378  328 TYR A CG  
2065 C CD1 . TYR A 148 ? 0.25519 0.14097 0.43039 -0.00889 -0.18373 0.01378  328 TYR A CD1 
2066 C CD2 . TYR A 148 ? 0.27809 0.16674 0.46122 -0.00845 -0.18432 0.01272  328 TYR A CD2 
2067 C CE1 . TYR A 148 ? 0.26627 0.13958 0.42835 -0.00845 -0.19176 0.01277  328 TYR A CE1 
2068 C CE2 . TYR A 148 ? 0.31474 0.19045 0.48487 -0.00773 -0.19271 0.01164  328 TYR A CE2 
2069 C CZ  . TYR A 148 ? 0.28016 0.14879 0.44008 -0.00786 -0.19603 0.01171  328 TYR A CZ  
2070 O OH  . TYR A 148 ? 0.32186 0.17919 0.46966 -0.00740 -0.20364 0.01060  328 TYR A OH  
2080 N N   . TYR A 149 ? 0.28455 0.20239 0.58489 -0.00077 -0.17714 0.00179  329 TYR A N   
2081 C CA  . TYR A 149 ? 0.24467 0.16367 0.57356 0.00164  -0.18172 -0.00319 329 TYR A CA  
2082 C C   . TYR A 149 ? 0.27158 0.17564 0.57453 0.00191  -0.19438 -0.00312 329 TYR A C   
2083 O O   . TYR A 149 ? 0.36325 0.25738 0.63955 0.00123  -0.19941 -0.00158 329 TYR A O   
2084 C CB  . TYR A 149 ? 0.26827 0.19477 0.63703 0.00416  -0.17946 -0.00922 329 TYR A CB  
2085 C CG  . TYR A 149 ? 0.23725 0.17859 0.63545 0.00378  -0.16382 -0.01018 329 TYR A CG  
2086 C CD1 . TYR A 149 ? 0.22447 0.17782 0.65141 0.00214  -0.15155 -0.01228 329 TYR A CD1 
2087 C CD2 . TYR A 149 ? 0.22528 0.16931 0.61988 0.00349  -0.15887 -0.00946 329 TYR A CD2 
2088 C CE1 . TYR A 149 ? 0.21436 0.18022 0.66246 -0.00081 -0.13205 -0.01359 329 TYR A CE1 
2089 C CE2 . TYR A 149 ? 0.21361 0.17119 0.63230 0.00149  -0.14113 -0.01098 329 TYR A CE2 
2090 C CZ  . TYR A 149 ? 0.20939 0.17649 0.65268 -0.00118 -0.12625 -0.01300 329 TYR A CZ  
2091 O OH  . TYR A 149 ? 0.20321 0.17767 0.66339 -0.00438 -0.10417 -0.01423 329 TYR A OH  
2101 N N   . LEU A 150 ? 0.26658 0.16897 0.57838 0.00275  -0.19878 -0.00487 330 LEU A N   
2102 C CA  . LEU A 150 ? 0.52381 0.41231 0.81217 0.00297  -0.20959 -0.00484 330 LEU A CA  
2103 C C   . LEU A 150 ? 0.39200 0.28072 0.71079 0.00574  -0.21707 -0.01027 330 LEU A C   
2104 O O   . LEU A 150 ? 0.54232 0.42383 0.85115 0.00593  -0.22342 -0.01033 330 LEU A O   
2105 C CB  . LEU A 150 ? 0.37931 0.26168 0.63257 0.00031  -0.20790 -0.00010 330 LEU A CB  
2106 C CG  . LEU A 150 ? 0.52416 0.41403 0.78500 -0.00065 -0.20188 0.00136  330 LEU A CG  
2107 C CD1 . LEU A 150 ? 0.34650 0.25183 0.62763 -0.00174 -0.19016 0.00209  330 LEU A CD1 
2108 C CD2 . LEU A 150 ? 0.34412 0.23504 0.63130 0.00150  -0.20763 -0.00265 330 LEU A CD2 
2120 N N   . ASN A 151 ? 0.37334 0.26987 0.72991 0.00786  -0.21642 -0.01529 331 ASN A N   
2121 C CA  . ASN A 151 ? 0.30211 0.19963 0.69172 0.01033  -0.22310 -0.02118 331 ASN A CA  
2122 C C   . ASN A 151 ? 0.44612 0.33324 0.83255 0.01235  -0.23519 -0.02451 331 ASN A C   
2123 O O   . ASN A 151 ? 0.32005 0.21062 0.72650 0.01365  -0.23518 -0.02816 331 ASN A O   
2124 C CB  . ASN A 151 ? 0.29307 0.20579 0.72920 0.01099  -0.21320 -0.02536 331 ASN A CB  
2125 C CG  . ASN A 151 ? 0.27671 0.19976 0.71661 0.00882  -0.19980 -0.02188 331 ASN A CG  
2126 O OD1 . ASN A 151 ? 0.29844 0.22233 0.74117 0.00821  -0.19973 -0.02108 331 ASN A OD1 
2127 N ND2 . ASN A 151 ? 0.26403 0.19462 0.70438 0.00764  -0.18857 -0.01991 331 ASN A ND2 
2134 N N   . LYS A 152 ? 0.33200 0.20598 0.69356 0.01262  -0.24542 -0.02350 332 LYS A N   
2135 C CA  . LYS A 152 ? 0.46922 0.33246 0.82932 0.01474  -0.25782 -0.02692 332 LYS A CA  
2136 C C   . LYS A 152 ? 0.59316 0.46017 0.99516 0.01768  -0.26455 -0.03410 332 LYS A C   
2137 O O   . LYS A 152 ? 0.56739 0.43946 0.98808 0.01794  -0.26353 -0.03559 332 LYS A O   
2138 C CB  . LYS A 152 ? 0.36199 0.21001 0.68424 0.01404  -0.26544 -0.02384 332 LYS A CB  
2139 C CG  . LYS A 152 ? 0.48603 0.32141 0.79727 0.01554  -0.27649 -0.02570 332 LYS A CG  
2144 N N   . ASP A 153 ? 0.60798 0.47231 1.02543 0.01982  -0.27169 -0.03884 333 ASP A N   
2145 C CA  . ASP A 153 ? 0.54261 0.41000 1.00119 0.02268  -0.27881 -0.04657 333 ASP A CA  
2146 C C   . ASP A 153 ? 0.36705 0.25120 0.86812 0.02242  -0.26729 -0.05013 333 ASP A C   
2147 O O   . ASP A 153 ? 0.38552 0.27421 0.92435 0.02414  -0.27052 -0.05648 333 ASP A O   
2148 C CB  . ASP A 153 ? 0.48806 0.34824 0.94751 0.02399  -0.28889 -0.04821 333 ASP A CB  
2149 C CG  . ASP A 153 ? 0.60055 0.44406 1.01756 0.02389  -0.29816 -0.04454 333 ASP A CG  
2150 O OD1 . ASP A 153 ? 0.77125 0.60697 1.18640 0.02522  -0.30756 -0.04613 333 ASP A OD1 
2151 O OD2 . ASP A 153 ? 0.76502 0.60305 1.15131 0.02237  -0.29568 -0.04024 333 ASP A OD2 
2156 N N   . TRP A 154 ? 0.34952 0.24279 0.84635 0.02022  -0.25334 -0.04641 334 TRP A N   
2157 C CA  . TRP A 154 ? 0.33803 0.24678 0.87504 0.01972  -0.24026 -0.04980 334 TRP A CA  
2158 C C   . TRP A 154 ? 0.40569 0.31742 0.97296 0.02150  -0.24229 -0.05677 334 TRP A C   
2159 O O   . TRP A 154 ? 0.37596 0.28219 0.92639 0.02195  -0.24654 -0.05629 334 TRP A O   
2160 C CB  . TRP A 154 ? 0.42489 0.34152 0.94755 0.01707  -0.22504 -0.04404 334 TRP A CB  
2161 C CG  . TRP A 154 ? 0.37186 0.30377 0.93374 0.01613  -0.20906 -0.04676 334 TRP A CG  
2162 C CD1 . TRP A 154 ? 0.42532 0.36593 1.01223 0.01595  -0.19860 -0.05018 334 TRP A CD1 
2163 C CD2 . TRP A 154 ? 0.32501 0.26449 0.90573 0.01497  -0.20055 -0.04645 334 TRP A CD2 
2164 N NE1 . TRP A 154 ? 0.29308 0.24576 0.91260 0.01460  -0.18262 -0.05191 334 TRP A NE1 
2165 C CE2 . TRP A 154 ? 0.33958 0.29183 0.95621 0.01397  -0.18368 -0.04958 334 TRP A CE2 
2166 C CE3 . TRP A 154 ? 0.30270 0.23882 0.87345 0.01453  -0.20515 -0.04399 334 TRP A CE3 
2167 C CZ2 . TRP A 154 ? 0.30557 0.26712 0.94749 0.01230  -0.17050 -0.05004 334 TRP A CZ2 
2168 C CZ3 . TRP A 154 ? 0.32416 0.27013 0.92095 0.01304  -0.19377 -0.04460 334 TRP A CZ3 
2169 C CH2 . TRP A 154 ? 0.29353 0.25363 0.92315 0.01099  -0.17568 -0.04743 334 TRP A CH2 
2180 N N   . ASP A 155 ? 0.36732 0.28757 0.98004 0.02235  -0.23916 -0.06352 335 ASP A N   
2181 C CA  . ASP A 155 ? 0.35387 0.27889 1.00189 0.02376  -0.23915 -0.07122 335 ASP A CA  
2182 C C   . ASP A 155 ? 0.41120 0.35156 1.09482 0.02180  -0.21946 -0.07336 335 ASP A C   
2183 O O   . ASP A 155 ? 0.34166 0.28825 1.05579 0.02142  -0.21420 -0.07645 335 ASP A O   
2184 C CB  . ASP A 155 ? 0.37313 0.29278 1.04504 0.02664  -0.25423 -0.07852 335 ASP A CB  
2185 C CG  . ASP A 155 ? 0.38017 0.30538 1.09188 0.02814  -0.25447 -0.08736 335 ASP A CG  
2186 O OD1 . ASP A 155 ? 0.37105 0.30281 1.08774 0.02701  -0.24405 -0.08757 335 ASP A OD1 
2187 O OD2 . ASP A 155 ? 0.39541 0.31842 1.13421 0.03051  -0.26532 -0.09448 335 ASP A OD2 
2192 N N   . ALA A 156 ? 0.33001 0.27581 1.00972 0.02044  -0.20804 -0.07179 336 ALA A N   
2193 C CA  . ALA A 156 ? 0.41764 0.37660 1.12405 0.01813  -0.18656 -0.07245 336 ALA A CA  
2194 C C   . ALA A 156 ? 0.34267 0.30908 1.10158 0.01856  -0.18120 -0.08165 336 ALA A C   
2195 O O   . ALA A 156 ? 0.32041 0.29552 1.10630 0.01671  -0.16540 -0.08283 336 ALA A O   
2196 C CB  . ALA A 156 ? 0.37695 0.33890 1.06760 0.01682  -0.17672 -0.06940 336 ALA A CB  
2202 N N   . LYS A 157 ? 0.36410 0.32698 1.13843 0.02090  -0.19370 -0.08841 337 LYS A N   
2203 C CA  . LYS A 157 ? 0.39170 0.36301 1.21650 0.02128  -0.18860 -0.09771 337 LYS A CA  
2204 C C   . LYS A 157 ? 0.35298 0.32945 1.20213 0.02085  -0.18782 -0.09999 337 LYS A C   
2205 O O   . LYS A 157 ? 0.42677 0.41645 1.31555 0.01954  -0.17620 -0.10554 337 LYS A O   
2206 C CB  . LYS A 157 ? 0.36209 0.32792 1.19596 0.02446  -0.20572 -0.10457 337 LYS A CB  
2207 C CG  . LYS A 157 ? 0.44010 0.40785 1.26626 0.02455  -0.20234 -0.10495 337 LYS A CG  
2208 C CD  . LYS A 157 ? 0.51217 0.49723 1.38068 0.02466  -0.18803 -0.11181 337 LYS A CD  
2215 N N   . VAL A 158 ? 0.45295 0.41989 1.27926 0.02173  -0.19956 -0.09587 338 VAL A N   
2216 C CA  . VAL A 158 ? 0.37802 0.34969 1.22420 0.02104  -0.20023 -0.09755 338 VAL A CA  
2217 C C   . VAL A 158 ? 0.34711 0.32324 1.17657 0.01789  -0.18716 -0.09004 338 VAL A C   
2218 O O   . VAL A 158 ? 0.34588 0.33356 1.20095 0.01485  -0.17411 -0.09135 338 VAL A O   
2219 C CB  . VAL A 158 ? 0.37676 0.33507 1.21335 0.02452  -0.22452 -0.09968 338 VAL A CB  
2220 C CG1 . VAL A 158 ? 0.39256 0.34935 1.25449 0.02737  -0.23634 -0.10858 338 VAL A CG1 
2221 C CG2 . VAL A 158 ? 0.37420 0.31816 1.15743 0.02559  -0.23572 -0.09186 338 VAL A CG2 
2231 N N   . SER A 159 ? 0.42778 0.39512 1.21389 0.01820  -0.19035 -0.08220 339 SER A N   
2232 C CA  . SER A 159 ? 0.32549 0.29667 1.09169 0.01538  -0.18043 -0.07501 339 SER A CA  
2233 C C   . SER A 159 ? 0.30995 0.29114 1.07518 0.01221  -0.15766 -0.07146 339 SER A C   
2234 O O   . SER A 159 ? 0.30037 0.28669 1.05358 0.00907  -0.14664 -0.06622 339 SER A O   
2235 C CB  . SER A 159 ? 0.32430 0.28165 1.04304 0.01707  -0.19513 -0.06831 339 SER A CB  
2236 O OG  . SER A 159 ? 0.40206 0.34871 1.11772 0.01983  -0.21525 -0.07127 339 SER A OG  
2242 N N   . GLY A 160 ? 0.30837 0.29211 1.08518 0.01262  -0.15025 -0.07436 340 GLY A N   
2243 C CA  . GLY A 160 ? 0.31895 0.31115 1.09431 0.00976  -0.12790 -0.07118 340 GLY A CA  
2244 C C   . GLY A 160 ? 0.29176 0.27931 1.02355 0.00931  -0.12753 -0.06248 340 GLY A C   
2245 O O   . GLY A 160 ? 0.39992 0.37628 1.10094 0.01178  -0.14419 -0.05958 340 GLY A O   
2249 N N   . GLY A 161 ? 0.34343 0.33930 1.07126 0.00570  -0.10770 -0.05823 341 GLY A N   
2250 C CA  . GLY A 161 ? 0.26326 0.25700 0.95144 0.00450  -0.10579 -0.05024 341 GLY A CA  
2251 C C   . GLY A 161 ? 0.35543 0.34663 1.02570 0.00573  -0.10317 -0.04804 341 GLY A C   
2252 O O   . GLY A 161 ? 0.38467 0.37179 1.01855 0.00560  -0.10849 -0.04186 341 GLY A O   
2256 N N   . ILE A 162 ? 0.26543 0.25919 0.95992 0.00636  -0.09518 -0.05314 342 ILE A N   
2257 C CA  . ILE A 162 ? 0.35735 0.34882 1.03653 0.00691  -0.09256 -0.05165 342 ILE A CA  
2258 C C   . ILE A 162 ? 0.36736 0.36586 1.03468 0.00404  -0.07002 -0.04638 342 ILE A C   
2259 O O   . ILE A 162 ? 0.23625 0.24209 0.92113 0.00126  -0.04987 -0.04686 342 ILE A O   
2260 C CB  . ILE A 162 ? 0.41453 0.40817 1.12317 0.00745  -0.09078 -0.05923 342 ILE A CB  
2261 C CG1 . ILE A 162 ? 0.40306 0.38972 1.11169 0.01008  -0.11540 -0.06340 342 ILE A CG1 
2262 C CG2 . ILE A 162 ? 0.27929 0.27546 0.97661 0.00664  -0.08092 -0.05770 342 ILE A CG2 
2263 C CD1 . ILE A 162 ? 0.31496 0.30504 1.06119 0.01092  -0.11508 -0.07230 342 ILE A CD1 
2275 N N   . LEU A 163 ? 0.30197 0.28368 0.95831 0.02392  0.15752  0.05071  343 LEU A N   
2276 C CA  . LEU A 163 ? 0.28689 0.26191 0.94283 0.01836  0.16131  0.05163  343 LEU A CA  
2277 C C   . LEU A 163 ? 0.33365 0.30759 0.99627 0.01798  0.16312  0.04769  343 LEU A C   
2278 O O   . LEU A 163 ? 0.29349 0.26615 0.96189 0.01903  0.16383  0.05003  343 LEU A O   
2279 C CB  . LEU A 163 ? 0.28555 0.25621 0.93948 0.01674  0.16289  0.05880  343 LEU A CB  
2280 C CG  . LEU A 163 ? 0.28535 0.25076 0.93957 0.01365  0.16497  0.05778  343 LEU A CG  
2281 C CD1 . LEU A 163 ? 0.28314 0.24768 0.92901 0.01310  0.16490  0.05483  343 LEU A CD1 
2282 C CD2 . LEU A 163 ? 0.28667 0.25193 0.93934 0.01434  0.16518  0.06239  343 LEU A CD2 
2294 N N   . ARG A 164 ? 0.29092 0.26573 0.95350 0.01714  0.16461  0.04175  344 ARG A N   
2295 C CA  . ARG A 164 ? 0.29471 0.27023 0.96261 0.01790  0.16615  0.03699  344 ARG A CA  
2296 C C   . ARG A 164 ? 0.33485 0.30622 1.00117 0.01547  0.16894  0.03707  344 ARG A C   
2297 O O   . ARG A 164 ? 0.29373 0.26409 0.95352 0.01470  0.17149  0.03672  344 ARG A O   
2298 C CB  . ARG A 164 ? 0.43629 0.41773 1.10591 0.01987  0.16711  0.02987  344 ARG A CB  
2299 C CG  . ARG A 164 ? 0.32560 0.30910 0.99934 0.02192  0.16889  0.02447  344 ARG A CG  
2300 C CD  . ARG A 164 ? 0.30758 0.29948 0.98556 0.02520  0.16916  0.01708  344 ARG A CD  
2301 N NE  . ARG A 164 ? 0.33651 0.33278 1.01843 0.03005  0.16334  0.01497  344 ARG A NE  
2302 C CZ  . ARG A 164 ? 0.43728 0.44284 1.12424 0.03459  0.16140  0.00719  344 ARG A CZ  
2303 N NH1 . ARG A 164 ? 0.31465 0.32675 1.00534 0.03353  0.16606  0.00116  344 ARG A NH1 
2304 N NH2 . ARG A 164 ? 0.39377 0.40259 1.08178 0.04141  0.15504  0.00519  344 ARG A NH2 
2318 N N   . ILE A 165 ? 0.29617 0.26594 0.96962 0.01508  0.16849  0.03689  345 ILE A N   
2319 C CA  . ILE A 165 ? 0.29683 0.26537 0.97195 0.01399  0.16947  0.03437  345 ILE A CA  
2320 C C   . ILE A 165 ? 0.30222 0.27409 0.98186 0.01716  0.16967  0.02701  345 ILE A C   
2321 O O   . ILE A 165 ? 0.30577 0.27822 0.99193 0.01918  0.16804  0.02515  345 ILE A O   
2322 C CB  . ILE A 165 ? 0.29601 0.26116 0.98002 0.01112  0.16865  0.03769  345 ILE A CB  
2323 C CG1 . ILE A 165 ? 0.29288 0.25602 0.97001 0.01042  0.16819  0.04516  345 ILE A CG1 
2324 C CG2 . ILE A 165 ? 0.29663 0.26277 0.98298 0.01079  0.16810  0.03280  345 ILE A CG2 
2325 C CD1 . ILE A 165 ? 0.29519 0.25830 0.97624 0.01035  0.16771  0.04820  345 ILE A CD1 
2337 N N   . PHE A 166 ? 0.30451 0.27883 0.97945 0.01926  0.17157  0.02267  346 PHE A N   
2338 C CA  . PHE A 166 ? 0.31145 0.28940 0.98808 0.02428  0.17186  0.01509  346 PHE A CA  
2339 C C   . PHE A 166 ? 0.31457 0.29231 0.99674 0.02589  0.16863  0.00986  346 PHE A C   
2340 O O   . PHE A 166 ? 0.31848 0.29921 0.99373 0.03035  0.16974  0.00574  346 PHE A O   
2341 C CB  . PHE A 166 ? 0.31514 0.29710 0.98189 0.02769  0.17783  0.01355  346 PHE A CB  
2342 C CG  . PHE A 166 ? 0.31309 0.29586 0.97794 0.02552  0.18090  0.01669  346 PHE A CG  
2343 C CD1 . PHE A 166 ? 0.31589 0.30283 0.98572 0.02763  0.18020  0.01286  346 PHE A CD1 
2344 C CD2 . PHE A 166 ? 0.36443 0.34435 1.02348 0.02227  0.18360  0.02202  346 PHE A CD2 
2345 C CE1 . PHE A 166 ? 0.35672 0.34651 1.02735 0.02619  0.18186  0.01332  346 PHE A CE1 
2346 C CE2 . PHE A 166 ? 0.30895 0.28981 0.96867 0.02068  0.18532  0.02280  346 PHE A CE2 
2347 C CZ  . PHE A 166 ? 0.40614 0.39275 1.07245 0.02244  0.18431  0.01797  346 PHE A CZ  
2357 N N   . PRO A 167 ? 0.35860 0.33297 1.05407 0.02321  0.16491  0.00928  347 PRO A N   
2358 C CA  . PRO A 167 ? 0.31842 0.29279 1.02356 0.02395  0.16111  0.00243  347 PRO A CA  
2359 C C   . PRO A 167 ? 0.32813 0.30534 1.02873 0.03243  0.15860  -0.00800 347 PRO A C   
2360 O O   . PRO A 167 ? 0.33917 0.31607 1.03801 0.03660  0.15840  -0.01095 347 PRO A O   
2361 C CB  . PRO A 167 ? 0.31975 0.28915 1.04299 0.01955  0.15971  0.00399  347 PRO A CB  
2362 C CG  . PRO A 167 ? 0.34082 0.30841 1.05971 0.02066  0.16139  0.00897  347 PRO A CG  
2363 C CD  . PRO A 167 ? 0.31419 0.28489 1.01773 0.02057  0.16446  0.01399  347 PRO A CD  
2371 N N   . GLU A 168 ? 0.33154 0.31191 1.02905 0.03662  0.15614  -0.01432 348 GLU A N   
2372 C CA  . GLU A 168 ? 0.34339 0.32649 1.03222 0.04749  0.15379  -0.02437 348 GLU A CA  
2373 C C   . GLU A 168 ? 0.43419 0.41372 1.13543 0.05005  0.14728  -0.03359 348 GLU A C   
2374 O O   . GLU A 168 ? 0.35192 0.32772 1.07173 0.04465  0.14272  -0.03659 348 GLU A O   
2375 C CB  . GLU A 168 ? 0.39499 0.38185 1.07757 0.05343  0.15078  -0.03042 348 GLU A CB  
2376 C CG  . GLU A 168 ? 0.40014 0.38933 1.06808 0.06791  0.14904  -0.04017 348 GLU A CG  
2383 N N   . GLY A 169 ? 0.44780 0.42819 1.13983 0.05844  0.14754  -0.03821 349 GLY A N   
2384 C CA  . GLY A 169 ? 0.43288 0.40925 1.13291 0.06344  0.14039  -0.04846 349 GLY A CA  
2385 C C   . GLY A 169 ? 0.49428 0.46407 1.20590 0.05777  0.13985  -0.04459 349 GLY A C   
2386 O O   . GLY A 169 ? 0.54748 0.51170 1.26585 0.06187  0.13361  -0.05289 349 GLY A O   
2390 N N   . LYS A 170 ? 0.38620 0.35562 1.09878 0.04998  0.14552  -0.03287 350 LYS A N   
2391 C CA  . LYS A 170 ? 0.36234 0.32516 1.08297 0.04680  0.14506  -0.02856 350 LYS A CA  
2392 C C   . LYS A 170 ? 0.44095 0.40735 1.15051 0.05276  0.14705  -0.02820 350 LYS A C   
2393 O O   . LYS A 170 ? 0.40366 0.37820 1.10259 0.05390  0.15241  -0.02548 350 LYS A O   
2394 C CB  . LYS A 170 ? 0.35148 0.31248 1.07890 0.03721  0.14930  -0.01695 350 LYS A CB  
2395 C CG  . LYS A 170 ? 0.34914 0.30781 1.09257 0.03051  0.14850  -0.01701 350 LYS A CG  
2396 C CD  . LYS A 170 ? 0.36185 0.31489 1.11949 0.03264  0.14193  -0.02855 350 LYS A CD  
2397 C CE  . LYS A 170 ? 0.37409 0.32792 1.15139 0.02577  0.14142  -0.03092 350 LYS A CE  
2398 N NZ  . LYS A 170 ? 0.37302 0.31931 1.17021 0.02527  0.13579  -0.04110 350 LYS A NZ  
2412 N N   . ALA A 171 ? 0.37518 0.33513 1.08822 0.05678  0.14289  -0.03146 351 ALA A N   
2413 C CA  . ALA A 171 ? 0.37925 0.34357 1.08408 0.06365  0.14347  -0.03311 351 ALA A CA  
2414 C C   . ALA A 171 ? 0.36997 0.33769 1.07266 0.05964  0.14761  -0.02404 351 ALA A C   
2415 O O   . ALA A 171 ? 0.37205 0.34622 1.06980 0.06493  0.14818  -0.02628 351 ALA A O   
2416 C CB  . ALA A 171 ? 0.39554 0.35016 1.10303 0.07060  0.13645  -0.03988 351 ALA A CB  
2422 N N   . GLN A 172 ? 0.36102 0.32555 1.06791 0.05140  0.14994  -0.01504 352 GLN A N   
2423 C CA  . GLN A 172 ? 0.35361 0.32103 1.05729 0.04876  0.15267  -0.00724 352 GLN A CA  
2424 C C   . GLN A 172 ? 0.34102 0.31033 1.04498 0.04024  0.15693  0.00035  352 GLN A C   
2425 O O   . GLN A 172 ? 0.33896 0.30572 1.04812 0.03618  0.15721  0.00055  352 GLN A O   
2426 C CB  . GLN A 172 ? 0.41094 0.36871 1.11652 0.05136  0.14964  -0.00333 352 GLN A CB  
2427 C CG  . GLN A 172 ? 0.37563 0.33164 1.07656 0.06170  0.14482  -0.01004 352 GLN A CG  
2428 C CD  . GLN A 172 ? 0.56698 0.50611 1.26901 0.06567  0.14075  -0.00929 352 GLN A CD  
2429 O OE1 . GLN A 172 ? 0.40174 0.33307 1.10896 0.06582  0.13819  -0.01434 352 GLN A OE1 
2430 N NE2 . GLN A 172 ? 0.64200 0.57382 1.33771 0.06977  0.13992  -0.00332 352 GLN A NE2 
2439 N N   . PHE A 173 ? 0.33384 0.30783 1.03246 0.03834  0.15935  0.00532  353 PHE A N   
2440 C CA  . PHE A 173 ? 0.32383 0.29783 1.02058 0.03145  0.16238  0.01281  353 PHE A CA  
2441 C C   . PHE A 173 ? 0.32342 0.29302 1.02269 0.03022  0.16165  0.02049  353 PHE A C   
2442 O O   . PHE A 173 ? 0.40800 0.37491 1.10716 0.03581  0.15907  0.02029  353 PHE A O   
2443 C CB  . PHE A 173 ? 0.31854 0.29893 1.00716 0.03051  0.16553  0.01290  353 PHE A CB  
2444 C CG  . PHE A 173 ? 0.32089 0.30699 1.00875 0.03465  0.16415  0.01003  353 PHE A CG  
2445 C CD1 . PHE A 173 ? 0.32081 0.30603 1.00890 0.03619  0.16085  0.01360  353 PHE A CD1 
2446 C CD2 . PHE A 173 ? 0.32452 0.31840 1.01173 0.03810  0.16636  0.00303  353 PHE A CD2 
2447 C CE1 . PHE A 173 ? 0.39036 0.38272 1.07836 0.04162  0.15807  0.00877  353 PHE A CE1 
2448 C CE2 . PHE A 173 ? 0.32691 0.32859 1.01630 0.04197  0.16469  -0.00148 353 PHE A CE2 
2449 C CZ  . PHE A 173 ? 0.36364 0.36484 1.05365 0.04397  0.15972  0.00067  353 PHE A CZ  
2459 N N   . ALA A 174 ? 0.28944 0.21258 0.73708 0.01916  0.13815  0.08905  354 ALA A N   
2460 C CA  . ALA A 174 ? 0.30372 0.22379 0.73364 0.01705  0.10897  0.08552  354 ALA A CA  
2461 C C   . ALA A 174 ? 0.33389 0.26813 0.79295 0.01282  0.08758  0.08874  354 ALA A C   
2462 O O   . ALA A 174 ? 0.34619 0.28206 0.79673 0.00835  0.08637  0.08913  354 ALA A O   
2463 C CB  . ALA A 174 ? 0.31653 0.21964 0.68288 0.01357  0.10403  0.07888  354 ALA A CB  
2469 N N   . ASP A 175 ? 0.27646 0.21970 0.76832 0.01406  0.06962  0.09077  355 ASP A N   
2470 C CA  . ASP A 175 ? 0.26096 0.21638 0.78011 0.00974  0.04624  0.09271  355 ASP A CA  
2471 C C   . ASP A 175 ? 0.32160 0.26778 0.80298 0.00731  0.02088  0.08699  355 ASP A C   
2472 O O   . ASP A 175 ? 0.31051 0.25074 0.78063 0.01009  0.01259  0.08596  355 ASP A O   
2473 C CB  . ASP A 175 ? 0.36561 0.33781 0.94782 0.01143  0.04134  0.09908  355 ASP A CB  
2474 C CG  . ASP A 175 ? 0.26076 0.24570 0.89016 0.01269  0.06497  0.10613  355 ASP A CG  
2475 O OD1 . ASP A 175 ? 0.30187 0.28489 0.91880 0.01144  0.07813  0.10680  355 ASP A OD1 
2476 O OD2 . ASP A 175 ? 0.33062 0.32611 1.00806 0.01465  0.07030  0.11141  355 ASP A OD2 
2481 N N   . ILE A 176 ? 0.30892 0.25321 0.77125 0.00244  0.00897  0.08357  356 ILE A N   
2482 C CA  . ILE A 176 ? 0.33200 0.26818 0.76067 0.00004  -0.01367 0.07789  356 ILE A CA  
2483 C C   . ILE A 176 ? 0.38496 0.33234 0.84667 -0.00329 -0.03779 0.07798  356 ILE A C   
2484 O O   . ILE A 176 ? 0.32179 0.27323 0.79433 -0.00639 -0.03939 0.07731  356 ILE A O   
2485 C CB  . ILE A 176 ? 0.26963 0.19269 0.64740 -0.00250 -0.00839 0.07227  356 ILE A CB  
2486 C CG1 . ILE A 176 ? 0.36213 0.27542 0.71303 -0.00033 0.01749  0.07261  356 ILE A CG1 
2487 C CG2 . ILE A 176 ? 0.34227 0.25682 0.68649 -0.00413 -0.02917 0.06684  356 ILE A CG2 
2488 C CD1 . ILE A 176 ? 0.41424 0.31983 0.75270 0.00339  0.02053  0.07269  356 ILE A CD1 
2500 N N   . GLU A 177 ? 0.33314 0.28433 0.81027 -0.00286 -0.05744 0.07893  357 GLU A N   
2501 C CA  . GLU A 177 ? 0.32649 0.28600 0.83042 -0.00681 -0.08377 0.07770  357 GLU A CA  
2502 C C   . GLU A 177 ? 0.36885 0.31784 0.83198 -0.00928 -0.10089 0.06933  357 GLU A C   
2503 O O   . GLU A 177 ? 0.24708 0.18447 0.66770 -0.00802 -0.10149 0.06647  357 GLU A O   
2504 C CB  . GLU A 177 ? 0.30644 0.27189 0.83760 -0.00659 -0.10052 0.08163  357 GLU A CB  
2505 C CG  . GLU A 177 ? 0.29590 0.27505 0.88269 -0.00595 -0.09024 0.08930  357 GLU A CG  
2506 C CD  . GLU A 177 ? 0.26195 0.24195 0.86468 -0.00452 -0.10150 0.09334  357 GLU A CD  
2507 O OE1 . GLU A 177 ? 0.30530 0.28051 0.89586 -0.00743 -0.12686 0.09124  357 GLU A OE1 
2508 O OE2 . GLU A 177 ? 0.39171 0.37575 1.01726 -0.00007 -0.08491 0.09846  357 GLU A OE2 
2515 N N   . PRO A 178 ? 0.29739 0.24966 0.77341 -0.01254 -0.11535 0.06512  358 PRO A N   
2516 C CA  . PRO A 178 ? 0.29243 0.23407 0.73128 -0.01389 -0.13194 0.05552  358 PRO A CA  
2517 C C   . PRO A 178 ? 0.38771 0.32587 0.81740 -0.01447 -0.15877 0.05265  358 PRO A C   
2518 O O   . PRO A 178 ? 0.26170 0.19875 0.69749 -0.01686 -0.18389 0.04606  358 PRO A O   
2519 C CB  . PRO A 178 ? 0.27015 0.21622 0.73205 -0.01583 -0.14037 0.05216  358 PRO A CB  
2520 C CG  . PRO A 178 ? 0.24780 0.20870 0.76595 -0.01618 -0.14100 0.06052  358 PRO A CG  
2521 C CD  . PRO A 178 ? 0.24389 0.20875 0.76861 -0.01435 -0.11681 0.06869  358 PRO A CD  
2529 N N   . LYS A 179 ? 0.35494 0.28940 0.76692 -0.01223 -0.15394 0.05742  359 LYS A N   
2530 C CA  . LYS A 179 ? 0.30496 0.23817 0.70696 -0.01247 -0.17757 0.05779  359 LYS A CA  
2531 C C   . LYS A 179 ? 0.26769 0.19873 0.62323 -0.01286 -0.19380 0.04789  359 LYS A C   
2532 O O   . LYS A 179 ? 0.27168 0.19720 0.59153 -0.01335 -0.18058 0.04185  359 LYS A O   
2533 C CB  . LYS A 179 ? 0.35876 0.28986 0.75195 -0.00951 -0.16657 0.06624  359 LYS A CB  
2534 C CG  . LYS A 179 ? 0.35149 0.28124 0.72051 -0.01013 -0.18791 0.06794  359 LYS A CG  
2535 C CD  . LYS A 179 ? 0.35296 0.27755 0.71749 -0.00726 -0.17680 0.07708  359 LYS A CD  
2536 C CE  . LYS A 179 ? 0.30000 0.22356 0.64002 -0.00934 -0.19801 0.08059  359 LYS A CE  
2545 N N   . PHE A 180 ? 0.31469 0.24752 0.65232 -0.01548 -0.21138 0.04273  360 PHE A N   
2546 C CA  . PHE A 180 ? 0.29408 0.22815 0.57836 -0.01622 -0.21915 0.03092  360 PHE A CA  
2547 C C   . PHE A 180 ? 0.32387 0.25982 0.56846 -0.01707 -0.21354 0.03265  360 PHE A C   
2548 O O   . PHE A 180 ? 0.28983 0.22475 0.53683 -0.01722 -0.21314 0.04353  360 PHE A O   
2549 C CB  . PHE A 180 ? 0.34131 0.27802 0.61460 -0.01702 -0.23397 0.02828  360 PHE A CB  
2550 C CG  . PHE A 180 ? 0.40135 0.34442 0.62196 -0.01720 -0.23776 0.01683  360 PHE A CG  
2551 C CD1 . PHE A 180 ? 0.46029 0.40468 0.66886 -0.01521 -0.23890 0.00344  360 PHE A CD1 
2552 C CD2 . PHE A 180 ? 0.34769 0.29680 0.53306 -0.01932 -0.23883 0.01992  360 PHE A CD2 
2553 C CE1 . PHE A 180 ? 0.45073 0.40547 0.61515 -0.01475 -0.23917 -0.00729 360 PHE A CE1 
2554 C CE2 . PHE A 180 ? 0.48288 0.44322 0.62361 -0.01984 -0.23838 0.00986  360 PHE A CE2 
2555 C CZ  . PHE A 180 ? 0.47912 0.44396 0.61054 -0.01731 -0.23772 -0.00402 360 PHE A CZ  
2565 N N   . ASP A 181 ? 0.31645 0.25416 0.52385 -0.01736 -0.20892 0.02206  361 ASP A N   
2566 C CA  . ASP A 181 ? 0.37084 0.31112 0.53278 -0.01955 -0.20309 0.02137  361 ASP A CA  
2567 C C   . ASP A 181 ? 0.30484 0.23435 0.46806 -0.01912 -0.18010 0.03036  361 ASP A C   
2568 O O   . ASP A 181 ? 0.29036 0.21786 0.41872 -0.02169 -0.17247 0.03336  361 ASP A O   
2569 C CB  . ASP A 181 ? 0.36397 0.30864 0.49726 -0.02214 -0.20939 0.02502  361 ASP A CB  
2570 C CG  . ASP A 181 ? 0.31751 0.26989 0.39616 -0.02493 -0.20153 0.01930  361 ASP A CG  
2571 O OD1 . ASP A 181 ? 0.35902 0.31489 0.41914 -0.02365 -0.19242 0.00963  361 ASP A OD1 
2572 O OD2 . ASP A 181 ? 0.31594 0.27213 0.37214 -0.02843 -0.20334 0.02487  361 ASP A OD2 
2577 N N   . ARG A 182 ? 0.37549 0.29701 0.57449 -0.01630 -0.16550 0.03438  362 ARG A N   
2578 C CA  . ARG A 182 ? 0.33187 0.24202 0.52999 -0.01517 -0.13953 0.04168  362 ARG A CA  
2579 C C   . ARG A 182 ? 0.33034 0.23716 0.50257 -0.01551 -0.12367 0.03473  362 ARG A C   
2580 O O   . ARG A 182 ? 0.27469 0.18359 0.45667 -0.01460 -0.12715 0.02803  362 ARG A O   
2581 C CB  . ARG A 182 ? 0.32601 0.23169 0.57721 -0.01190 -0.13047 0.05070  362 ARG A CB  
2582 C CG  . ARG A 182 ? 0.29306 0.18783 0.54500 -0.01013 -0.10168 0.05605  362 ARG A CG  
2583 C CD  . ARG A 182 ? 0.27196 0.17440 0.57037 -0.00673 -0.09041 0.06243  362 ARG A CD  
2584 N NE  . ARG A 182 ? 0.27174 0.17527 0.58289 -0.00437 -0.09601 0.06890  362 ARG A NE  
2585 C CZ  . ARG A 182 ? 0.27879 0.19138 0.62957 -0.00104 -0.08888 0.07389  362 ARG A CZ  
2586 N NH1 . ARG A 182 ? 0.25747 0.17976 0.64039 -0.00037 -0.07575 0.07425  362 ARG A NH1 
2587 N NH2 . ARG A 182 ? 0.27221 0.18404 0.63129 0.00140  -0.09562 0.07930  362 ARG A NH2 
2601 N N   . LEU A 183 ? 0.25605 0.15678 0.39562 -0.01697 -0.10732 0.03661  363 LEU A N   
2602 C CA  . LEU A 183 ? 0.32589 0.22311 0.44025 -0.01732 -0.09083 0.03184  363 LEU A CA  
2603 C C   . LEU A 183 ? 0.36053 0.24535 0.48799 -0.01610 -0.06615 0.03975  363 LEU A C   
2604 O O   . LEU A 183 ? 0.28205 0.16026 0.41620 -0.01574 -0.05957 0.04685  363 LEU A O   
2605 C CB  . LEU A 183 ? 0.38991 0.29243 0.45289 -0.02096 -0.09192 0.02640  363 LEU A CB  
2606 C CG  . LEU A 183 ? 0.25067 0.15294 0.28537 -0.02114 -0.07856 0.02037  363 LEU A CG  
2607 C CD1 . LEU A 183 ? 0.35754 0.26839 0.39382 -0.01815 -0.09048 0.00990  363 LEU A CD1 
2608 C CD2 . LEU A 183 ? 0.33265 0.23900 0.32168 -0.02599 -0.07481 0.01866  363 LEU A CD2 
2620 N N   . LEU A 184 ? 0.29424 0.17549 0.42480 -0.01520 -0.05275 0.03839  364 LEU A N   
2621 C CA  . LEU A 184 ? 0.24952 0.12090 0.39354 -0.01416 -0.02870 0.04533  364 LEU A CA  
2622 C C   . LEU A 184 ? 0.33115 0.19849 0.44084 -0.01566 -0.01405 0.04197  364 LEU A C   
2623 O O   . LEU A 184 ? 0.24470 0.11633 0.34417 -0.01562 -0.02128 0.03618  364 LEU A O   
2624 C CB  . LEU A 184 ? 0.24537 0.12035 0.43749 -0.01198 -0.02629 0.04983  364 LEU A CB  
2625 C CG  . LEU A 184 ? 0.27970 0.15535 0.47875 -0.01071 -0.00067 0.05395  364 LEU A CG  
2626 C CD1 . LEU A 184 ? 0.25447 0.12867 0.45858 -0.00815 0.01233  0.05783  364 LEU A CD1 
2627 C CD2 . LEU A 184 ? 0.25447 0.14113 0.49174 -0.01030 -0.00139 0.05635  364 LEU A CD2 
2639 N N   . PHE A 185 ? 0.34548 0.20411 0.43798 -0.01656 0.00565  0.04520  365 PHE A N   
2640 C CA  . PHE A 185 ? 0.27052 0.12440 0.33361 -0.01818 0.02196  0.04372  365 PHE A CA  
2641 C C   . PHE A 185 ? 0.28714 0.13277 0.37015 -0.01689 0.04490  0.05064  365 PHE A C   
2642 O O   . PHE A 185 ? 0.27189 0.11919 0.37161 -0.01439 0.05012  0.05272  365 PHE A O   
2643 C CB  . PHE A 185 ? 0.26133 0.11311 0.27848 -0.02180 0.02518  0.03986  365 PHE A CB  
2644 C CG  . PHE A 185 ? 0.30620 0.16931 0.29911 -0.02396 0.00542  0.03312  365 PHE A CG  
2645 C CD1 . PHE A 185 ? 0.33503 0.20675 0.30425 -0.02424 0.00024  0.02630  365 PHE A CD1 
2646 C CD2 . PHE A 185 ? 0.33905 0.20498 0.33214 -0.02551 -0.00765 0.03387  365 PHE A CD2 
2647 C CE1 . PHE A 185 ? 0.24971 0.13479 0.19684 -0.02572 -0.01639 0.01911  365 PHE A CE1 
2648 C CE2 . PHE A 185 ? 0.25638 0.13492 0.22521 -0.02824 -0.02456 0.02802  365 PHE A CE2 
2649 C CZ  . PHE A 185 ? 0.31202 0.20119 0.25802 -0.02822 -0.02824 0.02001  365 PHE A CZ  
2659 N N   . PHE A 186 ? 0.27013 0.11640 0.34533 -0.01742 0.05533  0.05115  366 PHE A N   
2660 C CA  . PHE A 186 ? 0.27019 0.11892 0.34966 -0.01603 0.07561  0.05390  366 PHE A CA  
2661 C C   . PHE A 186 ? 0.27459 0.12177 0.33020 -0.01795 0.08515  0.05425  366 PHE A C   
2662 O O   . PHE A 186 ? 0.28645 0.13243 0.33813 -0.01913 0.07542  0.05422  366 PHE A O   
2663 C CB  . PHE A 186 ? 0.26930 0.12783 0.39556 -0.01288 0.07747  0.05842  366 PHE A CB  
2664 C CG  . PHE A 186 ? 0.26470 0.12933 0.41367 -0.01377 0.06657  0.06045  366 PHE A CG  
2665 C CD1 . PHE A 186 ? 0.27335 0.14164 0.44111 -0.01354 0.04509  0.05832  366 PHE A CD1 
2666 C CD2 . PHE A 186 ? 0.27026 0.13654 0.42181 -0.01497 0.07710  0.06440  366 PHE A CD2 
2667 C CE1 . PHE A 186 ? 0.27595 0.14889 0.46466 -0.01439 0.03430  0.05885  366 PHE A CE1 
2668 C CE2 . PHE A 186 ? 0.26897 0.13880 0.44142 -0.01629 0.06634  0.06653  366 PHE A CE2 
2669 C CZ  . PHE A 186 ? 0.27550 0.14840 0.46679 -0.01590 0.04499  0.06316  366 PHE A CZ  
2679 N N   . TRP A 187 ? 0.30741 0.15371 0.34756 -0.01752 0.10355  0.05413  367 TRP A N   
2680 C CA  . TRP A 187 ? 0.29074 0.13705 0.30830 -0.01891 0.11166  0.05473  367 TRP A CA  
2681 C C   . TRP A 187 ? 0.29047 0.14104 0.33533 -0.01896 0.10881  0.06104  367 TRP A C   
2682 O O   . TRP A 187 ? 0.29105 0.14715 0.37188 -0.01735 0.11238  0.06513  367 TRP A O   
2683 C CB  . TRP A 187 ? 0.30405 0.14887 0.30692 -0.01738 0.13056  0.05266  367 TRP A CB  
2684 C CG  . TRP A 187 ? 0.32700 0.16550 0.30473 -0.01743 0.13364  0.04573  367 TRP A CG  
2685 C CD1 . TRP A 187 ? 0.36643 0.19906 0.34911 -0.01450 0.14719  0.04350  367 TRP A CD1 
2686 C CD2 . TRP A 187 ? 0.31502 0.15151 0.25941 -0.02080 0.12315  0.04009  367 TRP A CD2 
2687 N NE1 . TRP A 187 ? 0.33708 0.16216 0.29136 -0.01633 0.14462  0.03698  367 TRP A NE1 
2688 C CE2 . TRP A 187 ? 0.36298 0.19218 0.29402 -0.02059 0.12935  0.03489  367 TRP A CE2 
2689 C CE3 . TRP A 187 ? 0.40795 0.24785 0.33300 -0.02387 0.10970  0.03879  367 TRP A CE3 
2690 C CZ2 . TRP A 187 ? 0.31227 0.13965 0.21320 -0.02438 0.12054  0.02887  367 TRP A CZ2 
2691 C CZ3 . TRP A 187 ? 0.39180 0.23254 0.28672 -0.02692 0.10221  0.03229  367 TRP A CZ3 
2692 C CH2 . TRP A 187 ? 0.37636 0.21203 0.26102 -0.02760 0.10655  0.02761  367 TRP A CH2 
2703 N N   . SER A 188 ? 0.30255 0.15036 0.33094 -0.02084 0.10227  0.06208  368 SER A N   
2704 C CA  . SER A 188 ? 0.29346 0.14213 0.34569 -0.02156 0.09666  0.06806  368 SER A CA  
2705 C C   . SER A 188 ? 0.32013 0.17177 0.37448 -0.02262 0.11191  0.07432  368 SER A C   
2706 O O   . SER A 188 ? 0.32345 0.17673 0.40297 -0.02406 0.10962  0.08070  368 SER A O   
2707 C CB  . SER A 188 ? 0.29230 0.13324 0.32747 -0.02202 0.08304  0.06695  368 SER A CB  
2708 O OG  . SER A 188 ? 0.28372 0.12036 0.30597 -0.02088 0.07218  0.06019  368 SER A OG  
2714 N N   . ASP A 189 ? 0.31578 0.16774 0.34418 -0.02216 0.12615  0.07211  369 ASP A N   
2715 C CA  . ASP A 189 ? 0.33202 0.18571 0.35604 -0.02339 0.13889  0.07730  369 ASP A CA  
2716 C C   . ASP A 189 ? 0.38105 0.23988 0.43806 -0.02185 0.15210  0.08112  369 ASP A C   
2717 O O   . ASP A 189 ? 0.32878 0.19108 0.41694 -0.01981 0.14922  0.08087  369 ASP A O   
2718 C CB  . ASP A 189 ? 0.41052 0.26277 0.39430 -0.02329 0.14524  0.07160  369 ASP A CB  
2719 C CG  . ASP A 189 ? 0.43501 0.28551 0.41135 -0.02039 0.15319  0.06340  369 ASP A CG  
2720 O OD1 . ASP A 189 ? 0.41677 0.26740 0.41967 -0.01802 0.15614  0.06342  369 ASP A OD1 
2721 O OD2 . ASP A 189 ? 0.34746 0.19618 0.29329 -0.02065 0.15499  0.05707  369 ASP A OD2 
2726 N N   . ARG A 190 ? 0.35623 0.21649 0.40714 -0.02277 0.16638  0.08484  370 ARG A N   
2727 C CA  . ARG A 190 ? 0.36600 0.23190 0.44870 -0.02158 0.18060  0.08989  370 ARG A CA  
2728 C C   . ARG A 190 ? 0.36359 0.22922 0.45860 -0.01594 0.19082  0.08385  370 ARG A C   
2729 O O   . ARG A 190 ? 0.37527 0.24650 0.50319 -0.01370 0.20237  0.08780  370 ARG A O   
2730 C CB  . ARG A 190 ? 0.38922 0.25618 0.45625 -0.02452 0.19371  0.09474  370 ARG A CB  
2731 C CG  . ARG A 190 ? 0.50896 0.37502 0.56400 -0.03056 0.18490  0.10259  370 ARG A CG  
2732 C CD  . ARG A 190 ? 0.54982 0.41604 0.57268 -0.03366 0.19360  0.10421  370 ARG A CD  
2733 N NE  . ARG A 190 ? 0.71989 0.58589 0.74021 -0.04020 0.18843  0.11533  370 ARG A NE  
2734 C CZ  . ARG A 190 ? 0.50505 0.37494 0.54895 -0.04477 0.19488  0.12608  370 ARG A CZ  
2735 N NH1 . ARG A 190 ? 0.58095 0.45778 0.65450 -0.04302 0.20759  0.12715  370 ARG A NH1 
2736 N NH2 . ARG A 190 ? 0.60484 0.47131 0.64348 -0.05144 0.18832  0.13651  370 ARG A NH2 
2750 N N   . ARG A 191 ? 0.36376 0.22267 0.43418 -0.01380 0.18728  0.07495  371 ARG A N   
2751 C CA  . ARG A 191 ? 0.47405 0.32968 0.55648 -0.00874 0.19633  0.06995  371 ARG A CA  
2752 C C   . ARG A 191 ? 0.37353 0.23652 0.50146 -0.00671 0.18932  0.07358  371 ARG A C   
2753 O O   . ARG A 191 ? 0.51348 0.37669 0.66552 -0.00197 0.19923  0.07274  371 ARG A O   
2754 C CB  . ARG A 191 ? 0.55589 0.40192 0.60142 -0.00859 0.19103  0.06053  371 ARG A CB  
2755 C CG  . ARG A 191 ? 0.44496 0.28398 0.45061 -0.00982 0.19808  0.05501  371 ARG A CG  
2756 C CD  . ARG A 191 ? 0.51834 0.34927 0.49077 -0.01084 0.18966  0.04582  371 ARG A CD  
2757 N NE  . ARG A 191 ? 0.44220 0.27818 0.40167 -0.01430 0.17110  0.04586  371 ARG A NE  
2758 C CZ  . ARG A 191 ? 0.56981 0.40313 0.50108 -0.01646 0.16052  0.03905  371 ARG A CZ  
2759 N NH1 . ARG A 191 ? 0.47022 0.29476 0.38302 -0.01639 0.16470  0.03174  371 ARG A NH1 
2760 N NH2 . ARG A 191 ? 0.64761 0.48677 0.57023 -0.01906 0.14531  0.03967  371 ARG A NH2 
2774 N N   . ASN A 192 ? 0.32802 0.19656 0.46957 -0.01007 0.17133  0.07727  372 ASN A N   
2775 C CA  . ASN A 192 ? 0.31397 0.19005 0.49624 -0.00901 0.15857  0.07933  372 ASN A CA  
2776 C C   . ASN A 192 ? 0.32436 0.20874 0.53680 -0.01215 0.15085  0.08665  372 ASN A C   
2777 O O   . ASN A 192 ? 0.37291 0.25687 0.58612 -0.01514 0.13125  0.08615  372 ASN A O   
2778 C CB  . ASN A 192 ? 0.39493 0.26648 0.56023 -0.01020 0.13849  0.07359  372 ASN A CB  
2779 C CG  . ASN A 192 ? 0.35962 0.22392 0.50642 -0.00753 0.14368  0.06772  372 ASN A CG  
2780 O OD1 . ASN A 192 ? 0.39394 0.25836 0.55879 -0.00328 0.15812  0.06811  372 ASN A OD1 
2781 N ND2 . ASN A 192 ? 0.29645 0.15352 0.40825 -0.01002 0.13226  0.06249  372 ASN A ND2 
2788 N N   . PRO A 193 ? 0.35756 0.24848 0.59501 -0.01170 0.16575  0.09327  373 PRO A N   
2789 C CA  . PRO A 193 ? 0.32394 0.22407 0.59964 -0.01480 0.15753  0.10069  373 PRO A CA  
2790 C C   . PRO A 193 ? 0.30879 0.21722 0.62341 -0.01262 0.14247  0.09931  373 PRO A C   
2791 O O   . PRO A 193 ? 0.30359 0.21364 0.62806 -0.00785 0.14600  0.09594  373 PRO A O   
2792 C CB  . PRO A 193 ? 0.39120 0.29733 0.68538 -0.01425 0.17938  0.10773  373 PRO A CB  
2793 C CG  . PRO A 193 ? 0.39610 0.29362 0.65134 -0.01177 0.19740  0.10319  373 PRO A CG  
2794 C CD  . PRO A 193 ? 0.34197 0.23158 0.57421 -0.00850 0.19024  0.09384  373 PRO A CD  
2802 N N   . HIS A 194 ? 0.30357 0.21633 0.63952 -0.01627 0.12412  0.10163  374 HIS A N   
2803 C CA  . HIS A 194 ? 0.31018 0.23131 0.68058 -0.01468 0.10663  0.09952  374 HIS A CA  
2804 C C   . HIS A 194 ? 0.33231 0.26062 0.73717 -0.01872 0.09299  0.10433  374 HIS A C   
2805 O O   . HIS A 194 ? 0.30191 0.22521 0.69659 -0.02332 0.09265  0.10795  374 HIS A O   
2806 C CB  . HIS A 194 ? 0.27927 0.19259 0.62037 -0.01420 0.08839  0.09046  374 HIS A CB  
2807 C CG  . HIS A 194 ? 0.28003 0.18229 0.58527 -0.01782 0.07739  0.08696  374 HIS A CG  
2808 N ND1 . HIS A 194 ? 0.28693 0.17891 0.55102 -0.01884 0.08895  0.08657  374 HIS A ND1 
2809 C CD2 . HIS A 194 ? 0.29552 0.19513 0.60147 -0.01999 0.05571  0.08333  374 HIS A CD2 
2810 C CE1 . HIS A 194 ? 0.31667 0.20029 0.55983 -0.02126 0.07504  0.08378  374 HIS A CE1 
2811 N NE2 . HIS A 194 ? 0.30115 0.18848 0.56877 -0.02162 0.05527  0.08121  374 HIS A NE2 
2819 N N   . GLU A 195 ? 0.28834 0.22787 0.73470 -0.01713 0.08081  0.10457  375 GLU A N   
2820 C CA  . GLU A 195 ? 0.31535 0.26258 0.79926 -0.02071 0.06581  0.10842  375 GLU A CA  
2821 C C   . GLU A 195 ? 0.40501 0.35704 0.90579 -0.01962 0.04059  0.10225  375 GLU A C   
2822 O O   . GLU A 195 ? 0.31189 0.26674 0.81363 -0.01560 0.03891  0.09889  375 GLU A O   
2823 C CB  . GLU A 195 ? 0.29629 0.25611 0.82648 -0.02018 0.08050  0.11848  375 GLU A CB  
2824 C CG  . GLU A 195 ? 0.28896 0.26075 0.85796 -0.01415 0.08194  0.11918  375 GLU A CG  
2825 C CD  . GLU A 195 ? 0.38449 0.36573 0.99052 -0.01173 0.10354  0.12841  375 GLU A CD  
2826 O OE1 . GLU A 195 ? 0.31529 0.29258 0.90429 -0.01411 0.12299  0.13297  375 GLU A OE1 
2827 O OE2 . GLU A 195 ? 0.36456 0.35680 1.01606 -0.00759 0.10044  0.13122  375 GLU A OE2 
2834 N N   . VAL A 196 ? 0.33082 0.28271 0.84384 -0.02343 0.02031  0.10077  376 VAL A N   
2835 C CA  . VAL A 196 ? 0.27010 0.22735 0.80340 -0.02295 -0.00551 0.09528  376 VAL A CA  
2836 C C   . VAL A 196 ? 0.27528 0.24624 0.86593 -0.02364 -0.00930 0.10312  376 VAL A C   
2837 O O   . VAL A 196 ? 0.28581 0.25587 0.89164 -0.02792 -0.01427 0.10675  376 VAL A O   
2838 C CB  . VAL A 196 ? 0.27156 0.21788 0.77902 -0.02561 -0.02667 0.08657  376 VAL A CB  
2839 C CG1 . VAL A 196 ? 0.26772 0.21965 0.79692 -0.02496 -0.05396 0.08058  376 VAL A CG1 
2840 C CG2 . VAL A 196 ? 0.36778 0.30054 0.82034 -0.02416 -0.02205 0.07961  376 VAL A CG2 
2850 N N   . GLN A 197 ? 0.28174 0.26431 0.90513 -0.01935 -0.00738 0.10623  377 GLN A N   
2851 C CA  . GLN A 197 ? 0.27637 0.27120 0.95586 -0.01879 -0.00980 0.11452  377 GLN A CA  
2852 C C   . GLN A 197 ? 0.30855 0.30330 1.00579 -0.02174 -0.03954 0.11111  377 GLN A C   
2853 O O   . GLN A 197 ? 0.38097 0.36939 1.05323 -0.02213 -0.05933 0.10151  377 GLN A O   
2854 C CB  . GLN A 197 ? 0.35562 0.36078 1.06674 -0.01217 -0.00376 0.11801  377 GLN A CB  
2855 C CG  . GLN A 197 ? 0.27700 0.28106 0.97468 -0.00820 0.02668  0.12085  377 GLN A CG  
2856 C CD  . GLN A 197 ? 0.29337 0.30620 1.02743 -0.00081 0.03304  0.12435  377 GLN A CD  
2857 O OE1 . GLN A 197 ? 0.26126 0.27991 1.01771 0.00105  0.01225  0.12286  377 GLN A OE1 
2858 N NE2 . GLN A 197 ? 0.27515 0.28744 1.01493 0.00365  0.06143  0.12901  377 GLN A NE2 
2867 N N   . PRO A 198 ? 0.29237 0.29240 1.03042 -0.02398 -0.04301 0.11855  378 PRO A N   
2868 C CA  . PRO A 198 ? 0.38123 0.37771 1.13285 -0.02723 -0.07061 0.11498  378 PRO A CA  
2869 C C   . PRO A 198 ? 0.29412 0.28902 1.04280 -0.02323 -0.09576 0.10667  378 PRO A C   
2870 O O   . PRO A 198 ? 0.36770 0.36825 1.13273 -0.01808 -0.09567 0.10898  378 PRO A O   
2871 C CB  . PRO A 198 ? 0.31558 0.31994 1.11787 -0.02930 -0.06761 0.12600  378 PRO A CB  
2872 C CG  . PRO A 198 ? 0.39774 0.40843 1.20563 -0.02886 -0.03563 0.13526  378 PRO A CG  
2873 C CD  . PRO A 198 ? 0.30365 0.30984 1.06796 -0.02535 -0.01991 0.13007  378 PRO A CD  
2881 N N   . ALA A 199 ? 0.29814 0.28308 1.02451 -0.02535 -0.11762 0.09706  379 ALA A N   
2882 C CA  . ALA A 199 ? 0.29822 0.27750 1.01576 -0.02198 -0.14367 0.08848  379 ALA A CA  
2883 C C   . ALA A 199 ? 0.34719 0.32026 1.09160 -0.02357 -0.16602 0.08826  379 ALA A C   
2884 O O   . ALA A 199 ? 0.32902 0.29821 1.07723 -0.02819 -0.16930 0.08760  379 ALA A O   
2885 C CB  . ALA A 199 ? 0.29258 0.26185 0.95908 -0.02228 -0.15155 0.07590  379 ALA A CB  
2891 N N   . TYR A 200 ? 0.32591 0.29499 1.08635 -0.02088 -0.18102 0.08897  380 TYR A N   
2892 C CA  . TYR A 200 ? 0.34851 0.30932 1.12914 -0.02390 -0.20268 0.08747  380 TYR A CA  
2893 C C   . TYR A 200 ? 0.35938 0.30396 1.10604 -0.02299 -0.22726 0.07439  380 TYR A C   
2894 O O   . TYR A 200 ? 0.37978 0.31788 1.13834 -0.02582 -0.24576 0.07167  380 TYR A O   
2895 C CB  . TYR A 200 ? 0.38076 0.34802 1.20547 -0.02488 -0.19940 0.09835  380 TYR A CB  
2896 C CG  . TYR A 200 ? 0.35010 0.33268 1.20621 -0.02560 -0.17293 0.11059  380 TYR A CG  
2897 C CD1 . TYR A 200 ? 0.36035 0.34789 1.23787 -0.03134 -0.16843 0.11546  380 TYR A CD1 
2898 C CD2 . TYR A 200 ? 0.37592 0.36623 1.23762 -0.02120 -0.15164 0.11693  380 TYR A CD2 
2899 C CE1 . TYR A 200 ? 0.35860 0.35845 1.25970 -0.03324 -0.14286 0.12658  380 TYR A CE1 
2900 C CE2 . TYR A 200 ? 0.40323 0.40599 1.28925 -0.02182 -0.12552 0.12691  380 TYR A CE2 
2901 C CZ  . TYR A 200 ? 0.34609 0.35359 1.25032 -0.02815 -0.12096 0.13182  380 TYR A CZ  
2902 O OH  . TYR A 200 ? 0.43638 0.45463 1.36045 -0.02985 -0.09424 0.14193  380 TYR A OH  
2912 N N   . ALA A 201 ? 0.34814 0.28727 1.05110 -0.01994 -0.22684 0.06576  381 ALA A N   
2913 C CA  . ALA A 201 ? 0.36049 0.28448 1.02339 -0.01952 -0.24678 0.05150  381 ALA A CA  
2914 C C   . ALA A 201 ? 0.34929 0.27042 0.97320 -0.01710 -0.24193 0.04267  381 ALA A C   
2915 O O   . ALA A 201 ? 0.35111 0.28312 0.97608 -0.01691 -0.22302 0.04798  381 ALA A O   
2916 C CB  . ALA A 201 ? 0.36314 0.28351 1.00901 -0.01984 -0.25262 0.05010  381 ALA A CB  
2922 N N   . THR A 202 ? 0.36289 0.27103 0.95067 -0.01606 -0.25789 0.02815  382 THR A N   
2923 C CA  . THR A 202 ? 0.35582 0.25957 0.90523 -0.01338 -0.25470 0.01829  382 THR A CA  
2924 C C   . THR A 202 ? 0.33591 0.24439 0.85932 -0.01202 -0.24140 0.02013  382 THR A C   
2925 O O   . THR A 202 ? 0.35907 0.26454 0.86191 -0.01226 -0.24642 0.01732  382 THR A O   
2926 C CB  . THR A 202 ? 0.38498 0.27564 0.90103 -0.01146 -0.27324 0.00123  382 THR A CB  
2927 O OG1 . THR A 202 ? 0.48846 0.37444 1.03101 -0.01305 -0.28628 -0.00044 382 THR A OG1 
2928 C CG2 . THR A 202 ? 0.37191 0.25777 0.84983 -0.00765 -0.26949 -0.00952 382 THR A CG2 
2936 N N   . ARG A 203 ? 0.33728 0.25510 0.85942 -0.01251 -0.22383 0.02451  383 ARG A N   
2937 C CA  . ARG A 203 ? 0.30162 0.22656 0.80397 -0.01269 -0.20845 0.02752  383 ARG A CA  
2938 C C   . ARG A 203 ? 0.29401 0.21233 0.75365 -0.01223 -0.20488 0.01727  383 ARG A C   
2939 O O   . ARG A 203 ? 0.29469 0.21168 0.75470 -0.01428 -0.19718 0.01681  383 ARG A O   
2940 C CB  . ARG A 203 ? 0.36195 0.30304 0.89571 -0.01635 -0.18466 0.04122  383 ARG A CB  
2941 C CG  . ARG A 203 ? 0.26765 0.21264 0.77765 -0.01777 -0.16336 0.04411  383 ARG A CG  
2942 C CD  . ARG A 203 ? 0.29981 0.25257 0.83042 -0.02014 -0.13584 0.05547  383 ARG A CD  
2943 N NE  . ARG A 203 ? 0.25365 0.20613 0.76204 -0.01941 -0.11374 0.05910  383 ARG A NE  
2944 C CZ  . ARG A 203 ? 0.25171 0.19328 0.71630 -0.01926 -0.09976 0.05588  383 ARG A CZ  
2945 N NH1 . ARG A 203 ? 0.25628 0.18774 0.69578 -0.02005 -0.10564 0.04881  383 ARG A NH1 
2946 N NH2 . ARG A 203 ? 0.25904 0.19892 0.70524 -0.01753 -0.07998 0.05974  383 ARG A NH2 
2960 N N   . TYR A 204 ? 0.29325 0.20534 0.71420 -0.00996 -0.20960 0.00956  384 TYR A N   
2961 C CA  . TYR A 204 ? 0.31520 0.22053 0.69352 -0.00828 -0.20782 -0.00144 384 TYR A CA  
2962 C C   . TYR A 204 ? 0.35091 0.25926 0.70937 -0.01107 -0.18921 0.00343  384 TYR A C   
2963 O O   . TYR A 204 ? 0.41318 0.32689 0.77885 -0.01294 -0.18338 0.01139  384 TYR A O   
2964 C CB  . TYR A 204 ? 0.30802 0.20674 0.64736 -0.00457 -0.22329 -0.01633 384 TYR A CB  
2965 C CG  . TYR A 204 ? 0.32941 0.22155 0.67561 -0.00189 -0.23873 -0.02510 384 TYR A CG  
2966 C CD1 . TYR A 204 ? 0.34750 0.23372 0.70771 0.00013  -0.24115 -0.02794 384 TYR A CD1 
2967 C CD2 . TYR A 204 ? 0.34581 0.23919 0.68355 -0.00206 -0.25087 -0.03035 384 TYR A CD2 
2968 C CE1 . TYR A 204 ? 0.35645 0.23555 0.72395 0.00252  -0.25622 -0.03634 384 TYR A CE1 
2969 C CE2 . TYR A 204 ? 0.36715 0.25490 0.71091 -0.00017 -0.26488 -0.03907 384 TYR A CE2 
2970 C CZ  . TYR A 204 ? 0.39742 0.27679 0.75671 0.00237  -0.26786 -0.04237 384 TYR A CZ  
2971 O OH  . TYR A 204 ? 0.39585 0.26868 0.76204 0.00422  -0.28282 -0.05142 384 TYR A OH  
2981 N N   . ALA A 205 ? 0.27360 0.17516 0.60487 -0.01066 -0.17923 -0.00124 385 ALA A N   
2982 C CA  . ALA A 205 ? 0.29510 0.19238 0.59610 -0.01156 -0.16123 0.00171  385 ALA A CA  
2983 C C   . ALA A 205 ? 0.26819 0.15640 0.53191 -0.00845 -0.16334 -0.01013 385 ALA A C   
2984 O O   . ALA A 205 ? 0.38076 0.26600 0.64739 -0.00566 -0.17193 -0.01724 385 ALA A O   
2985 C CB  . ALA A 205 ? 0.25777 0.15757 0.57294 -0.01388 -0.13339 0.01642  385 ALA A CB  
2991 N N   . ILE A 206 ? 0.26286 0.15142 0.48894 -0.00753 -0.15414 -0.01174 386 ILE A N   
2992 C CA  . ILE A 206 ? 0.32115 0.20905 0.50803 -0.00321 -0.15085 -0.02106 386 ILE A CA  
2993 C C   . ILE A 206 ? 0.35749 0.24217 0.52506 -0.00421 -0.12520 -0.01052 386 ILE A C   
2994 O O   . ILE A 206 ? 0.25131 0.14187 0.40444 -0.00611 -0.11615 -0.00523 386 ILE A O   
2995 C CB  . ILE A 206 ? 0.26704 0.16928 0.41779 -0.00011 -0.16554 -0.03558 386 ILE A CB  
2996 C CG1 . ILE A 206 ? 0.27804 0.18418 0.44380 0.00196  -0.18738 -0.04481 386 ILE A CG1 
2997 C CG2 . ILE A 206 ? 0.26899 0.17309 0.38425 0.00523  -0.16232 -0.04591 386 ILE A CG2 
2998 C CD1 . ILE A 206 ? 0.28710 0.20739 0.41003 0.00759  -0.18900 -0.05562 386 ILE A CD1 
3010 N N   . SER A 207 ? 0.34197 0.21624 0.50825 -0.00315 -0.11447 -0.00752 387 SER A N   
3011 C CA  . SER A 207 ? 0.25588 0.12545 0.40714 -0.00478 -0.09008 0.00316  387 SER A CA  
3012 C C   . SER A 207 ? 0.32579 0.19666 0.43669 -0.00079 -0.08690 -0.00399 387 SER A C   
3013 O O   . SER A 207 ? 0.26376 0.13352 0.36988 0.00392  -0.10036 -0.01431 387 SER A O   
3014 C CB  . SER A 207 ? 0.35994 0.21933 0.54358 -0.00809 -0.07687 0.01613  387 SER A CB  
3015 O OG  . SER A 207 ? 0.34426 0.21387 0.55943 -0.01126 -0.07333 0.02339  387 SER A OG  
3021 N N   . VAL A 208 ? 0.25327 0.12653 0.33611 -0.00240 -0.06942 0.00108  388 VAL A N   
3022 C CA  . VAL A 208 ? 0.25900 0.13446 0.30517 0.00036  -0.06361 -0.00314 388 VAL A CA  
3023 C C   . VAL A 208 ? 0.25543 0.12323 0.29248 -0.00344 -0.03982 0.00934  388 VAL A C   
3024 O O   . VAL A 208 ? 0.25895 0.12498 0.30434 -0.00756 -0.02775 0.01732  388 VAL A O   
3025 C CB  . VAL A 208 ? 0.50587 0.39816 0.51636 0.00174  -0.07101 -0.01428 388 VAL A CB  
3026 C CG1 . VAL A 208 ? 0.36966 0.26622 0.34362 0.00274  -0.06054 -0.01554 388 VAL A CG1 
3027 C CG2 . VAL A 208 ? 0.25389 0.15477 0.26737 0.00689  -0.09374 -0.02892 388 VAL A CG2 
3037 N N   . TRP A 209 ? 0.26119 0.12419 0.28108 -0.00153 -0.03355 0.01065  389 TRP A N   
3038 C CA  . TRP A 209 ? 0.26587 0.12209 0.27132 -0.00510 -0.01179 0.02139  389 TRP A CA  
3039 C C   . TRP A 209 ? 0.26526 0.12979 0.22739 -0.00363 -0.00942 0.01549  389 TRP A C   
3040 O O   . TRP A 209 ? 0.27945 0.14673 0.23050 0.00156  -0.01924 0.00918  389 TRP A O   
3041 C CB  . TRP A 209 ? 0.30461 0.14682 0.33065 -0.00573 -0.00549 0.03174  389 TRP A CB  
3042 C CG  . TRP A 209 ? 0.29647 0.13228 0.36581 -0.00940 -0.00264 0.04039  389 TRP A CG  
3043 C CD1 . TRP A 209 ? 0.27597 0.11007 0.35905 -0.01407 0.01559  0.05050  389 TRP A CD1 
3044 C CD2 . TRP A 209 ? 0.27853 0.11000 0.38464 -0.00866 -0.01873 0.03909  389 TRP A CD2 
3045 N NE1 . TRP A 209 ? 0.27663 0.11391 0.39836 -0.01575 0.01172  0.05404  389 TRP A NE1 
3046 C CE2 . TRP A 209 ? 0.27828 0.11381 0.41426 -0.01326 -0.00879 0.04771  389 TRP A CE2 
3047 C CE3 . TRP A 209 ? 0.32136 0.15075 0.43382 -0.00399 -0.04048 0.02906  389 TRP A CE3 
3048 C CZ2 . TRP A 209 ? 0.28080 0.12234 0.45040 -0.01426 -0.01956 0.04717  389 TRP A CZ2 
3049 C CZ3 . TRP A 209 ? 0.30232 0.13203 0.45036 -0.00548 -0.05111 0.02902  389 TRP A CZ3 
3050 C CH2 . TRP A 209 ? 0.28473 0.12281 0.45959 -0.01106 -0.04026 0.03834  389 TRP A CH2 
3061 N N   . TYR A 210 ? 0.26266 0.13114 0.20192 -0.00806 0.00294  0.01726  390 TYR A N   
3062 C CA  . TYR A 210 ? 0.30035 0.17781 0.19922 -0.00865 0.00613  0.01256  390 TYR A CA  
3063 C C   . TYR A 210 ? 0.27347 0.14163 0.15789 -0.01040 0.02203  0.02120  390 TYR A C   
3064 O O   . TYR A 210 ? 0.33793 0.19440 0.23419 -0.01400 0.03745  0.03127  390 TYR A O   
3065 C CB  . TYR A 210 ? 0.27754 0.16198 0.15817 -0.01393 0.01029  0.01042  390 TYR A CB  
3066 C CG  . TYR A 210 ? 0.35804 0.25503 0.24324 -0.01269 -0.00702 0.00168  390 TYR A CG  
3067 C CD1 . TYR A 210 ? 0.29113 0.20570 0.15159 -0.01100 -0.01820 -0.00880 390 TYR A CD1 
3068 C CD2 . TYR A 210 ? 0.30355 0.19657 0.21822 -0.01314 -0.01246 0.00399  390 TYR A CD2 
3069 C CE1 . TYR A 210 ? 0.24453 0.17204 0.10667 -0.01031 -0.03339 -0.01672 390 TYR A CE1 
3070 C CE2 . TYR A 210 ? 0.31638 0.22107 0.23288 -0.01243 -0.02916 -0.00347 390 TYR A CE2 
3071 C CZ  . TYR A 210 ? 0.24301 0.16476 0.13188 -0.01122 -0.03918 -0.01384 390 TYR A CZ  
3072 O OH  . TYR A 210 ? 0.31185 0.24673 0.19964 -0.01099 -0.05500 -0.02125 390 TYR A OH  
3082 N N   . PHE A 211 ? 0.27701 0.15181 0.13602 -0.00756 0.01803  0.01715  391 PHE A N   
3083 C CA  . PHE A 211 ? 0.31452 0.18142 0.15802 -0.00849 0.02941  0.02532  391 PHE A CA  
3084 C C   . PHE A 211 ? 0.34201 0.21376 0.14931 -0.01430 0.04180  0.02536  391 PHE A C   
3085 O O   . PHE A 211 ? 0.39052 0.28370 0.19226 -0.01461 0.03357  0.01552  391 PHE A O   
3086 C CB  . PHE A 211 ? 0.31487 0.18509 0.15380 -0.00108 0.01620  0.02169  391 PHE A CB  
3087 C CG  . PHE A 211 ? 0.29679 0.15713 0.17004 0.00421  0.00451  0.02267  391 PHE A CG  
3088 C CD1 . PHE A 211 ? 0.36582 0.20899 0.26292 0.00102  0.01335  0.03569  391 PHE A CD1 
3089 C CD2 . PHE A 211 ? 0.42806 0.29661 0.30945 0.01199  -0.01523 0.01020  391 PHE A CD2 
3090 C CE1 . PHE A 211 ? 0.31016 0.14323 0.23980 0.00440  0.00174  0.03709  391 PHE A CE1 
3091 C CE2 . PHE A 211 ? 0.29798 0.15513 0.21058 0.01646  -0.02712 0.00999  391 PHE A CE2 
3092 C CZ  . PHE A 211 ? 0.30672 0.14541 0.24394 0.01214  -0.01911 0.02391  391 PHE A CZ  
3102 N N   . ASP A 212 ? 0.29818 0.16592 0.10835 -0.01735 0.05540  0.03272  392 ASP A N   
3103 C CA  . ASP A 212 ? 0.30514 0.19840 0.11890 -0.01831 0.05374  0.02719  392 ASP A CA  
3104 C C   . ASP A 212 ? 0.31484 0.21934 0.12058 -0.01474 0.04620  0.02699  392 ASP A C   
3105 O O   . ASP A 212 ? 0.41795 0.30403 0.21499 -0.01283 0.04860  0.03487  392 ASP A O   
3106 C CB  . ASP A 212 ? 0.36516 0.25396 0.18792 -0.02120 0.06609  0.03196  392 ASP A CB  
3107 C CG  . ASP A 212 ? 0.40770 0.31723 0.23090 -0.02180 0.06306  0.02786  392 ASP A CG  
3108 O OD1 . ASP A 212 ? 0.35722 0.27568 0.18093 -0.02254 0.05808  0.02134  392 ASP A OD1 
3109 O OD2 . ASP A 212 ? 0.39304 0.30472 0.21327 -0.02205 0.06661  0.03207  392 ASP A OD2 
3114 N N   . ALA A 213 ? 0.37666 0.31196 0.18901 -0.01290 0.03746  0.02012  393 ALA A N   
3115 C CA  . ALA A 213 ? 0.39931 0.35025 0.20784 -0.00860 0.02977  0.01892  393 ALA A CA  
3116 C C   . ALA A 213 ? 0.45982 0.40037 0.25976 -0.00983 0.03564  0.02749  393 ALA A C   
3117 O O   . ALA A 213 ? 0.45073 0.37612 0.23720 -0.00688 0.03292  0.03227  393 ALA A O   
3118 C CB  . ALA A 213 ? 0.37141 0.34521 0.18330 -0.00715 0.02470  0.01183  393 ALA A CB  
3124 N N   . ASP A 214 ? 0.49093 0.43398 0.29410 -0.01340 0.04306  0.02970  394 ASP A N   
3125 C CA  . ASP A 214 ? 0.46090 0.39936 0.25594 -0.01475 0.04790  0.03716  394 ASP A CA  
3126 C C   . ASP A 214 ? 0.58590 0.49930 0.37819 -0.01620 0.05553  0.04769  394 ASP A C   
3127 O O   . ASP A 214 ? 0.47177 0.37599 0.25457 -0.01502 0.05475  0.05606  394 ASP A O   
3128 C CB  . ASP A 214 ? 0.36333 0.29735 0.15171 -0.01910 0.05539  0.03467  394 ASP A CB  
3129 C CG  . ASP A 214 ? 0.56069 0.50526 0.34424 -0.01943 0.04990  0.02662  394 ASP A CG  
3130 O OD1 . ASP A 214 ? 0.56361 0.52271 0.34546 -0.01541 0.04173  0.02494  394 ASP A OD1 
3131 O OD2 . ASP A 214 ? 0.57420 0.51233 0.35603 -0.02375 0.05392  0.02244  394 ASP A OD2 
3136 N N   . GLU A 215 ? 0.46646 0.36526 0.26699 -0.01851 0.06377  0.04870  395 GLU A N   
3137 C CA  . GLU A 215 ? 0.54029 0.41654 0.34590 -0.01977 0.07276  0.06016  395 GLU A CA  
3138 C C   . GLU A 215 ? 0.42571 0.28182 0.22637 -0.01546 0.06632  0.06669  395 GLU A C   
3139 O O   . GLU A 215 ? 0.50799 0.34975 0.31249 -0.01531 0.06753  0.07907  395 GLU A O   
3140 C CB  . GLU A 215 ? 0.35873 0.22838 0.18094 -0.02212 0.08217  0.05936  395 GLU A CB  
3141 C CG  . GLU A 215 ? 0.42746 0.28428 0.26706 -0.02433 0.09187  0.07127  395 GLU A CG  
3142 C CD  . GLU A 215 ? 0.46772 0.32098 0.32907 -0.02544 0.09991  0.07007  395 GLU A CD  
3143 O OE1 . GLU A 215 ? 0.58021 0.44101 0.43988 -0.02625 0.10581  0.06359  395 GLU A OE1 
3144 O OE2 . GLU A 215 ? 0.37939 0.22186 0.26256 -0.02509 0.09879  0.07578  395 GLU A OE2 
3151 N N   . ARG A 216 ? 0.34948 0.20331 0.14238 -0.01143 0.05726  0.05901  396 ARG A N   
3152 C CA  . ARG A 216 ? 0.47515 0.31036 0.26608 -0.00413 0.04458  0.06234  396 ARG A CA  
3153 C C   . ARG A 216 ? 0.50190 0.33745 0.27483 0.00134  0.03546  0.06541  396 ARG A C   
3154 O O   . ARG A 216 ? 0.40885 0.23331 0.20017 0.00663  0.02531  0.07090  396 ARG A O   
3155 C CB  . ARG A 216 ? 0.44989 0.30005 0.24853 0.00042  0.03051  0.04607  396 ARG A CB  
3156 C CG  . ARG A 216 ? 0.37995 0.22922 0.20386 0.00979  0.01025  0.03945  396 ARG A CG  
3157 C CD  . ARG A 216 ? 0.34243 0.17190 0.20083 0.00888  0.01047  0.05003  396 ARG A CD  
3158 N NE  . ARG A 216 ? 0.41698 0.24384 0.30085 0.01709  -0.00980 0.04150  396 ARG A NE  
3159 C CZ  . ARG A 216 ? 0.42964 0.24008 0.34687 0.01671  -0.01468 0.04785  396 ARG A CZ  
3160 N NH1 . ARG A 216 ? 0.35713 0.15435 0.28822 0.00842  -0.00011 0.06388  396 ARG A NH1 
3161 N NH2 . ARG A 216 ? 0.37849 0.18637 0.31591 0.02451  -0.03456 0.03740  396 ARG A NH2 
3175 N N   . ALA A 217 ? 0.44509 0.30740 0.20619 -0.00011 0.03450  0.05729  397 ALA A N   
3176 C CA  . ALA A 217 ? 0.51142 0.37883 0.26107 0.00440  0.02613  0.06027  397 ALA A CA  
3177 C C   . ALA A 217 ? 0.52522 0.37584 0.27634 0.00115  0.03356  0.07727  397 ALA A C   
3178 O O   . ALA A 217 ? 0.50260 0.33465 0.24659 0.00749  0.02459  0.08733  397 ALA A O   
3179 C CB  . ALA A 217 ? 0.42722 0.33542 0.18361 0.00070  0.02435  0.04950  397 ALA A CB  
3185 N N   . ARG A 218 ? 0.54509 0.40396 0.30877 -0.00776 0.04759  0.08024  398 ARG A N   
3186 C CA  . ARG A 218 ? 0.40868 0.25881 0.17714 -0.01208 0.05446  0.09521  398 ARG A CA  
3187 C C   . ARG A 218 ? 0.45984 0.28065 0.24387 -0.01067 0.05367  0.10836  398 ARG A C   
3188 O O   . ARG A 218 ? 0.44550 0.25408 0.23207 -0.01053 0.05000  0.12206  398 ARG A O   
3189 C CB  . ARG A 218 ? 0.45272 0.31890 0.23092 -0.01986 0.06723  0.09323  398 ARG A CB  
3190 C CG  . ARG A 218 ? 0.38981 0.28370 0.16050 -0.02098 0.06550  0.08411  398 ARG A CG  
3191 C CD  . ARG A 218 ? 0.47845 0.38138 0.25501 -0.02633 0.07618  0.08452  398 ARG A CD  
3192 N NE  . ARG A 218 ? 0.50021 0.39702 0.29013 -0.02758 0.08333  0.07897  398 ARG A NE  
3193 C CZ  . ARG A 218 ? 0.49582 0.40142 0.28883 -0.02672 0.08283  0.06702  398 ARG A CZ  
3194 N NH1 . ARG A 218 ? 0.56573 0.47873 0.34594 -0.02534 0.07784  0.05831  398 ARG A NH1 
3195 N NH2 . ARG A 218 ? 0.52304 0.42136 0.32834 -0.02759 0.08910  0.06405  398 ARG A NH2 
3209 N N   . ALA A 219 ? 0.49265 0.30361 0.29338 -0.01014 0.05532  0.10472  399 ALA A N   
3210 C CA  . ALA A 219 ? 0.51476 0.30248 0.34408 -0.00917 0.05107  0.11487  399 ALA A CA  
3211 C C   . ALA A 219 ? 0.49047 0.26269 0.32039 0.00127  0.03022  0.11548  399 ALA A C   
3212 O O   . ALA A 219 ? 0.45314 0.20793 0.30176 0.00136  0.02447  0.12777  399 ALA A O   
3213 C CB  . ALA A 219 ? 0.51722 0.30241 0.36944 -0.00990 0.05349  0.10773  399 ALA A CB  
3219 N N   . LYS A 220 ? 0.42451 0.21169 0.24236 0.01001  0.01624  0.09884  400 LYS A N   
3220 C CA  . LYS A 220 ? 0.45321 0.23733 0.27873 0.02175  -0.00601 0.09334  400 LYS A CA  
3221 C C   . LYS A 220 ? 0.45757 0.23198 0.26372 0.02325  -0.00783 0.10786  400 LYS A C   
3222 O O   . LYS A 220 ? 0.50849 0.26741 0.33051 0.02976  -0.02238 0.11331  400 LYS A O   
3223 C CB  . LYS A 220 ? 0.56860 0.37556 0.38302 0.03043  -0.01783 0.07222  400 LYS A CB  
3224 C CG  . LYS A 220 ? 0.39074 0.20305 0.23153 0.03346  -0.02647 0.05711  400 LYS A CG  
3225 C CD  . LYS A 220 ? 0.42302 0.26024 0.25001 0.04128  -0.03698 0.03722  400 LYS A CD  
3226 C CE  . LYS A 220 ? 0.44512 0.28785 0.29555 0.04397  -0.04621 0.02264  400 LYS A CE  
3227 N NZ  . LYS A 220 ? 0.59410 0.42212 0.47355 0.05306  -0.06407 0.01835  400 LYS A NZ  
3241 N N   . VAL A 221 ? 0.54558 0.32781 0.31688 0.01726  0.00576  0.11428  401 VAL A N   
3242 C CA  . VAL A 221 ? 0.56251 0.33965 0.31681 0.01696  0.00451  0.12861  401 VAL A CA  
3243 C C   . VAL A 221 ? 0.50353 0.26377 0.28339 0.01002  0.00928  0.14682  401 VAL A C   
3244 O O   . VAL A 221 ? 0.62743 0.37355 0.41230 0.01436  -0.00231 0.15809  401 VAL A O   
3245 C CB  . VAL A 221 ? 0.64525 0.45539 0.38321 0.00806  0.01735  0.12362  401 VAL A CB  
3246 C CG1 . VAL A 221 ? 0.49627 0.30857 0.23027 0.00357  0.01891  0.13877  401 VAL A CG1 
3247 C CG2 . VAL A 221 ? 0.61934 0.45278 0.34111 0.01419  0.00851  0.10649  401 VAL A CG2 
3257 N N   . LYS A 222 ? 0.51771 0.28283 0.31723 -0.00104 0.02521  0.14935  402 LYS A N   
3258 C CA  . LYS A 222 ? 0.53748 0.29327 0.36375 -0.00978 0.02886  0.16556  402 LYS A CA  
3259 C C   . LYS A 222 ? 0.51909 0.24901 0.37485 -0.00308 0.01224  0.16999  402 LYS A C   
3260 O O   . LYS A 222 ? 0.57099 0.28955 0.44108 -0.00525 0.00560  0.18499  402 LYS A O   
3261 C CB  . LYS A 222 ? 0.59767 0.36597 0.43924 -0.02142 0.04547  0.16314  402 LYS A CB  
3262 C CG  . LYS A 222 ? 0.66075 0.44982 0.48661 -0.03100 0.05947  0.16645  402 LYS A CG  
3263 C CD  . LYS A 222 ? 0.63980 0.44307 0.47616 -0.03707 0.07435  0.15775  402 LYS A CD  
3270 N N   . TYR A 223 ? 0.58054 0.30217 0.44779 0.00485  0.00374  0.15592  403 TYR A N   
3271 C CA  . TYR A 223 ? 0.51049 0.21310 0.41167 0.01139  -0.01483 0.15378  403 TYR A CA  
3272 C C   . TYR A 223 ? 0.60648 0.29963 0.50054 0.02336  -0.03564 0.15326  403 TYR A C   
3273 O O   . TYR A 223 ? 0.58598 0.26637 0.50322 0.02509  -0.04253 0.15933  403 TYR A O   
3274 C CB  . TYR A 223 ? 0.57360 0.28499 0.49342 0.01629  -0.02373 0.13240  403 TYR A CB  
3275 C CG  . TYR A 223 ? 0.57823 0.27571 0.52967 0.02517  -0.04757 0.12358  403 TYR A CG  
3276 C CD1 . TYR A 223 ? 0.61701 0.30963 0.60349 0.01925  -0.04476 0.12516  403 TYR A CD1 
3277 C CD2 . TYR A 223 ? 0.63749 0.34032 0.58168 0.04004  -0.06730 0.10684  403 TYR A CD2 
3278 C CE1 . TYR A 223 ? 0.66631 0.35338 0.67841 0.02621  -0.06362 0.11322  403 TYR A CE1 
3279 C CE2 . TYR A 223 ? 0.66396 0.35744 0.63631 0.04861  -0.08713 0.09565  403 TYR A CE2 
3280 C CZ  . TYR A 223 ? 0.68840 0.37621 0.69435 0.04064  -0.08406 0.09841  403 TYR A CZ  
3281 O OH  . TYR A 223 ? 0.85334 0.53712 0.88323 0.04722  -0.10161 0.08494  403 TYR A OH  
3291 N N   . LEU A 224 ? 0.66468 0.37165 0.52869 0.03256  -0.04262 0.14214  404 LEU A N   
3292 C CA  . LEU A 224 ? 0.58095 0.28257 0.44058 0.04647  -0.06382 0.13889  404 LEU A CA  
3293 C C   . LEU A 224 ? 0.59830 0.28932 0.44632 0.04306  -0.06113 0.16094  404 LEU A C   
3294 O O   . LEU A 224 ? 0.80156 0.48478 0.65708 0.05345  -0.07815 0.16141  404 LEU A O   
3295 C CB  . LEU A 224 ? 0.63616 0.36641 0.47139 0.05624  -0.06851 0.11935  404 LEU A CB  
3296 C CG  . LEU A 224 ? 0.60660 0.35546 0.45494 0.06098  -0.07266 0.09477  404 LEU A CG  
3297 C CD1 . LEU A 224 ? 0.57711 0.35711 0.39647 0.06546  -0.07112 0.08003  404 LEU A CD1 
3298 C CD2 . LEU A 224 ? 0.56279 0.30043 0.44209 0.07369  -0.09505 0.08206  404 LEU A CD2 
3310 N N   . THR A 225 ? 0.59587 0.29465 0.43117 0.02910  -0.03856 0.17627  405 THR A N   
3311 C CA  . THR A 225 ? 0.61238 0.31066 0.43981 0.02496  -0.03287 0.19580  405 THR A CA  
3312 C C   . THR A 225 ? 0.65918 0.34016 0.51205 0.01837  -0.02178 0.21045  405 THR A C   
3313 O O   . THR A 225 ? 0.67700 0.35304 0.51812 0.01485  -0.01244 0.22663  405 THR A O   
3314 C CB  . THR A 225 ? 0.59168 0.31560 0.38899 0.01461  -0.01573 0.19970  405 THR A CB  
3315 O OG1 . THR A 225 ? 0.65811 0.39364 0.46455 0.00140  0.00235  0.19723  405 THR A OG1 
3316 C CG2 . THR A 225 ? 0.64501 0.38467 0.41059 0.02298  -0.02305 0.18330  405 THR A CG2 
3324 N N   . GLY A 226 ? 0.65706 0.32518 0.53605 0.01672  -0.02238 0.20182  406 GLY A N   
3325 C CA  . GLY A 226 ? 0.92043 0.56781 0.81173 0.00714  -0.01480 0.20915  406 GLY A CA  
3326 C C   . GLY A 226 ? 0.99280 0.64092 0.86576 -0.01034 0.00633  0.21132  406 GLY A C   
3327 O O   . GLY A 226 ? 1.28540 0.92331 1.15237 -0.02270 0.01363  0.22275  406 GLY A O   
3331 N N   . LEU B 1   ? 0.53252 0.45417 0.92429 0.00046  0.16323  -0.09792 524 LEU B N   
3332 C CA  . LEU B 1   ? 0.52748 0.41872 0.87251 0.00742  0.16575  -0.09432 524 LEU B CA  
3333 C C   . LEU B 1   ? 0.51109 0.40394 0.83793 0.01213  0.14294  -0.09310 524 LEU B C   
3334 O O   . LEU B 1   ? 0.51789 0.41445 0.83783 0.01559  0.13182  -0.09351 524 LEU B O   
3335 C CB  . LEU B 1   ? 0.36756 0.23016 0.69119 0.00548  0.18422  -0.09327 524 LEU B CB  
3339 N N   . ASP B 2   ? 0.43271 0.32187 0.75350 0.01175  0.13730  -0.09269 525 ASP B N   
3340 C CA  . ASP B 2   ? 0.30824 0.20256 0.62151 0.01488  0.11754  -0.09378 525 ASP B CA  
3341 C C   . ASP B 2   ? 0.39158 0.31697 0.73460 0.00908  0.10880  -0.09544 525 ASP B C   
3342 O O   . ASP B 2   ? 0.34480 0.28577 0.71074 0.00334  0.10919  -0.09590 525 ASP B O   
3343 C CB  . ASP B 2   ? 0.31854 0.20135 0.62141 0.01652  0.11395  -0.09382 525 ASP B CB  
3344 C CG  . ASP B 2   ? 0.43158 0.31896 0.73104 0.02063  0.09469  -0.09719 525 ASP B CG  
3345 O OD1 . ASP B 2   ? 0.52409 0.43222 0.83955 0.01778  0.08717  -0.09971 525 ASP B OD1 
3346 O OD2 . ASP B 2   ? 0.47369 0.34177 0.75490 0.02656  0.08772  -0.09842 525 ASP B OD2 
3351 N N   . LEU B 3   ? 0.31145 0.24015 0.64956 0.01059  0.10108  -0.09689 526 LEU B N   
3352 C CA  . LEU B 3   ? 0.24807 0.19502 0.60383 0.00592  0.09484  -0.09872 526 LEU B CA  
3353 C C   . LEU B 3   ? 0.28999 0.24851 0.65536 0.00145  0.08753  -0.10106 526 LEU B C   
3354 O O   . LEU B 3   ? 0.22201 0.19046 0.59982 -0.00254 0.08490  -0.10232 526 LEU B O   
3355 C CB  . LEU B 3   ? 0.25327 0.19431 0.59539 0.00862  0.09090  -0.10015 526 LEU B CB  
3356 C CG  . LEU B 3   ? 0.28279 0.21598 0.62035 0.01279  0.09777  -0.09859 526 LEU B CG  
3357 C CD1 . LEU B 3   ? 0.35828 0.28178 0.67751 0.01584  0.09309  -0.10010 526 LEU B CD1 
3358 C CD2 . LEU B 3   ? 0.29679 0.24281 0.65980 0.01097  0.09906  -0.09948 526 LEU B CD2 
3370 N N   . GLU B 4   ? 0.31741 0.27183 0.67598 0.00340  0.08366  -0.10265 527 GLU B N   
3371 C CA  . GLU B 4   ? 0.35667 0.32285 0.72779 -0.00065 0.07891  -0.10599 527 GLU B CA  
3372 C C   . GLU B 4   ? 0.23332 0.20555 0.61650 -0.00420 0.08258  -0.10359 527 GLU B C   
3373 O O   . GLU B 4   ? 0.23470 0.21591 0.62749 -0.00816 0.08059  -0.10590 527 GLU B O   
3374 C CB  . GLU B 4   ? 0.35499 0.31533 0.72088 0.00431  0.07178  -0.11003 527 GLU B CB  
3375 C CG  . GLU B 4   ? 0.23597 0.19957 0.60487 0.00442  0.06543  -0.11706 527 GLU B CG  
3376 C CD  . GLU B 4   ? 0.38339 0.34991 0.76294 0.00807  0.05528  -0.12520 527 GLU B CD  
3377 O OE1 . GLU B 4   ? 0.37834 0.33173 0.74692 0.01576  0.05018  -0.12372 527 GLU B OE1 
3378 O OE2 . GLU B 4   ? 0.34403 0.32458 0.74391 0.00365  0.05270  -0.13436 527 GLU B OE2 
3385 N N   . THR B 5   ? 0.29776 0.26402 0.68157 -0.00327 0.08975  -0.10006 528 THR B N   
3386 C CA  . THR B 5   ? 0.25585 0.22893 0.65662 -0.00771 0.09363  -0.09945 528 THR B CA  
3387 C C   . THR B 5   ? 0.33229 0.31676 0.74972 -0.01121 0.08979  -0.10141 528 THR B C   
3388 O O   . THR B 5   ? 0.20260 0.19331 0.63555 -0.01398 0.08922  -0.10261 528 THR B O   
3389 C CB  . THR B 5   ? 0.32649 0.28987 0.72884 -0.00742 0.10602  -0.09749 528 THR B CB  
3390 O OG1 . THR B 5   ? 0.26538 0.22966 0.67525 -0.00762 0.11163  -0.09784 528 THR B OG1 
3391 C CG2 . THR B 5   ? 0.41266 0.35321 0.78637 -0.00088 0.10881  -0.09577 528 THR B CG2 
3399 N N   . LEU B 6   ? 0.29657 0.25005 0.63580 -0.03994 0.17273  -0.01895 529 LEU B N   
3400 C CA  . LEU B 6   ? 0.29655 0.27916 0.69123 -0.03241 0.15927  -0.00601 529 LEU B CA  
3401 C C   . LEU B 6   ? 0.23308 0.21548 0.60555 -0.02455 0.14064  -0.00890 529 LEU B C   
3402 O O   . LEU B 6   ? 0.28334 0.29784 0.69739 -0.02044 0.12305  0.00760  529 LEU B O   
3403 C CB  . LEU B 6   ? 0.26717 0.24905 0.70239 -0.01844 0.18524  0.00474  529 LEU B CB  
3404 C CG  . LEU B 6   ? 0.29683 0.26096 0.73015 -0.02150 0.21095  0.00049  529 LEU B CG  
3405 C CD1 . LEU B 6   ? 0.39303 0.32707 0.84388 -0.01061 0.24768  0.00165  529 LEU B CD1 
3406 C CD2 . LEU B 6   ? 0.29839 0.29671 0.77184 -0.02773 0.19285  0.01682  529 LEU B CD2 
3418 N N   . ALA B 7   ? 0.25112 0.20714 0.56194 -0.02487 0.14276  -0.02438 530 ALA B N   
3419 C CA  . ALA B 7   ? 0.41231 0.36708 0.70108 -0.01833 0.12716  -0.02803 530 ALA B CA  
3420 C C   . ALA B 7   ? 0.28852 0.25349 0.56371 -0.02112 0.09119  -0.02581 530 ALA B C   
3421 O O   . ALA B 7   ? 0.32079 0.27642 0.57802 -0.02905 0.08595  -0.02841 530 ALA B O   
3422 C CB  . ALA B 7   ? 0.40762 0.34111 0.63444 -0.02470 0.13993  -0.04272 530 ALA B CB  
3428 N N   . PRO B 8   ? 0.26248 0.24199 0.54513 -0.01693 0.07225  -0.02138 531 PRO B N   
3429 C CA  . PRO B 8   ? 0.21207 0.19652 0.47306 -0.02729 0.04432  -0.02467 531 PRO B CA  
3430 C C   . PRO B 8   ? 0.30509 0.25781 0.51148 -0.02401 0.04541  -0.03692 531 PRO B C   
3431 O O   . PRO B 8   ? 0.27896 0.22344 0.46086 -0.01447 0.05215  -0.03905 531 PRO B O   
3432 C CB  . PRO B 8   ? 0.19544 0.20840 0.47726 -0.02389 0.02689  -0.01259 531 PRO B CB  
3433 C CG  . PRO B 8   ? 0.19444 0.19614 0.48969 -0.00528 0.05081  -0.00981 531 PRO B CG  
3434 C CD  . PRO B 8   ? 0.19585 0.18266 0.50476 -0.00455 0.08183  -0.01344 531 PRO B CD  
3442 N N   . TYR B 9   ? 0.22147 0.15812 0.41250 -0.03486 0.04317  -0.04253 532 TYR B N   
3443 C CA  . TYR B 9   ? 0.25067 0.15920 0.40847 -0.02697 0.05256  -0.04321 532 TYR B CA  
3444 C C   . TYR B 9   ? 0.22523 0.13219 0.35905 -0.02065 0.04007  -0.04692 532 TYR B C   
3445 O O   . TYR B 9   ? 0.26698 0.18283 0.40046 -0.03108 0.02415  -0.05459 532 TYR B O   
3446 C CB  . TYR B 9   ? 0.26530 0.14429 0.42166 -0.03991 0.06724  -0.04872 532 TYR B CB  
3447 C CG  . TYR B 9   ? 0.28513 0.13199 0.42361 -0.02769 0.08575  -0.04197 532 TYR B CG  
3448 C CD1 . TYR B 9   ? 0.30200 0.14881 0.44657 -0.00990 0.10267  -0.01665 532 TYR B CD1 
3449 C CD2 . TYR B 9   ? 0.30517 0.13215 0.42277 -0.03431 0.08765  -0.05409 532 TYR B CD2 
3450 C CE1 . TYR B 9   ? 0.32619 0.15461 0.47206 0.00591  0.12274  0.00337  532 TYR B CE1 
3451 C CE2 . TYR B 9   ? 0.32765 0.13503 0.43836 -0.01849 0.10937  -0.04088 532 TYR B CE2 
3452 C CZ  . TYR B 9   ? 0.32467 0.13416 0.45627 0.00336  0.12744  -0.00973 532 TYR B CZ  
3453 O OH  . TYR B 9   ? 0.35889 0.16179 0.49960 0.02077  0.15102  0.01368  532 TYR B OH  
3463 N N   . ILE B 10  ? 0.22215 0.12616 0.33643 -0.00673 0.04608  -0.03721 533 ILE B N   
3464 C CA  . ILE B 10  ? 0.21951 0.11920 0.31289 0.00033  0.03918  -0.03752 533 ILE B CA  
3465 C C   . ILE B 10  ? 0.23652 0.12448 0.32796 0.01222  0.05762  -0.01758 533 ILE B C   
3466 O O   . ILE B 10  ? 0.28732 0.18826 0.38714 0.01642  0.06810  0.00275  533 ILE B O   
3467 C CB  . ILE B 10  ? 0.27759 0.19958 0.35805 0.00464  0.02797  -0.03764 533 ILE B CB  
3468 C CG1 . ILE B 10  ? 0.23718 0.17751 0.30712 0.00284  0.03812  -0.02617 533 ILE B CG1 
3469 C CG2 . ILE B 10  ? 0.27364 0.20491 0.37257 -0.00051 0.01848  -0.04728 533 ILE B CG2 
3470 C CD1 . ILE B 10  ? 0.19769 0.15517 0.24096 -0.00234 0.03436  -0.02886 533 ILE B CD1 
3482 N N   . PRO B 11  ? 0.33436 0.20107 0.42019 0.01811  0.06592  -0.01722 534 PRO B N   
3483 C CA  . PRO B 11  ? 0.30381 0.16552 0.40537 0.03629  0.09015  0.01438  534 PRO B CA  
3484 C C   . PRO B 11  ? 0.35080 0.26753 0.44994 0.04466  0.07721  0.04637  534 PRO B C   
3485 O O   . PRO B 11  ? 0.31504 0.25731 0.39125 0.03875  0.05578  0.03747  534 PRO B O   
3486 C CB  . PRO B 11  ? 0.34436 0.17831 0.43753 0.03851  0.10099  0.00437  534 PRO B CB  
3487 C CG  . PRO B 11  ? 0.37729 0.19650 0.44559 0.01214  0.08667  -0.03429 534 PRO B CG  
3488 C CD  . PRO B 11  ? 0.40217 0.24997 0.47125 0.00727  0.05859  -0.04114 534 PRO B CD  
3496 N N   . MET B 12  ? 0.34516 0.28373 0.46669 0.05356  0.09214  0.08594  535 MET B N   
3497 C CA  . MET B 12  ? 0.40144 0.40806 0.51464 0.04916  0.07807  0.12169  535 MET B CA  
3498 C C   . MET B 12  ? 0.32390 0.36690 0.46300 0.06724  0.08504  0.17150  535 MET B C   
3499 O O   . MET B 12  ? 0.42189 0.51518 0.54097 0.05761  0.06427  0.18193  535 MET B O   
3500 C CB  . MET B 12  ? 0.39456 0.42540 0.51418 0.04072  0.08443  0.14410  535 MET B CB  
3501 C CG  . MET B 12  ? 0.37203 0.38869 0.46517 0.01897  0.07636  0.10292  535 MET B CG  
3502 S SD  . MET B 12  ? 0.32815 0.36761 0.37351 -0.00596 0.05604  0.07094  535 MET B SD  
3503 C CE  . MET B 12  ? 0.25964 0.38167 0.27858 -0.02795 0.04805  0.11614  535 MET B CE  
3513 N N   . ASP B 13  ? 0.59824 0.61908 0.78583 0.09140  0.11825  0.20258  536 ASP B N   
3514 C CA  . ASP B 13  ? 0.80218 0.87949 1.02671 0.10423  0.12633  0.23980  536 ASP B CA  
3515 C C   . ASP B 13  ? 0.73576 0.78629 0.94818 0.10762  0.12785  0.21792  536 ASP B C   
3516 O O   . ASP B 13  ? 0.71227 0.81094 0.90945 0.10166  0.10256  0.22808  536 ASP B O   
3517 C CB  . ASP B 13  ? 0.77554 0.84752 1.05796 0.12181  0.16881  0.26336  536 ASP B CB  
3520 N N   . GLY B 14  ? 0.70725 0.68520 0.91954 0.10974  0.15687  0.18456  537 GLY B N   
3521 C CA  . GLY B 14  ? 0.68070 0.61816 0.86397 0.10419  0.15359  0.14768  537 GLY B CA  
3522 C C   . GLY B 14  ? 0.45686 0.44127 0.64052 0.11027  0.13676  0.16873  537 GLY B C   
3523 O O   . GLY B 14  ? 0.48059 0.52791 0.70204 0.11881  0.14388  0.21646  537 GLY B O   
3527 N N   . GLU B 15  ? 0.74522 0.70655 0.89041 0.10335  0.11454  0.13257  538 GLU B N   
3528 C CA  . GLU B 15  ? 0.62589 0.62988 0.76301 0.10546  0.09424  0.14526  538 GLU B CA  
3529 C C   . GLU B 15  ? 0.49646 0.52134 0.58925 0.08882  0.05462  0.12015  538 GLU B C   
3530 O O   . GLU B 15  ? 0.55279 0.64466 0.63531 0.07584  0.03331  0.14301  538 GLU B O   
3531 C CB  . GLU B 15  ? 0.65850 0.61718 0.78990 0.10715  0.11366  0.12248  538 GLU B CB  
3534 N N   . ASP B 16  ? 0.44051 0.41620 0.50134 0.07598  0.04621  0.06840  539 ASP B N   
3535 C CA  . ASP B 16  ? 0.39010 0.37363 0.41281 0.05714  0.01831  0.03592  539 ASP B CA  
3536 C C   . ASP B 16  ? 0.33290 0.30556 0.34155 0.05942  0.01363  0.02307  539 ASP B C   
3537 O O   . ASP B 16  ? 0.32365 0.30499 0.35024 0.07328  0.02693  0.04688  539 ASP B O   
3538 C CB  . ASP B 16  ? 0.25823 0.29741 0.26434 0.03993  0.00247  0.04858  539 ASP B CB  
3539 C CG  . ASP B 16  ? 0.18577 0.23315 0.19481 0.03082  0.00604  0.05308  539 ASP B CG  
3540 O OD1 . ASP B 16  ? 0.18979 0.19615 0.21082 0.03664  0.01466  0.03677  539 ASP B OD1 
3541 O OD2 . ASP B 16  ? 0.29245 0.39097 0.28752 0.01210  0.00035  0.07215  539 ASP B OD2 
3546 N N   A PHE B 17  ? 0.34195 0.29870 0.32534 0.04757  -0.00226 -0.00878 540 PHE B N   
3547 N N   B PHE B 17  ? 0.34353 0.30025 0.32692 0.04758  -0.00225 -0.00879 540 PHE B N   
3548 C CA  A PHE B 17  ? 0.28511 0.23576 0.25193 0.04715  -0.00900 -0.01978 540 PHE B CA  
3549 C CA  B PHE B 17  ? 0.27919 0.22980 0.24600 0.04716  -0.00899 -0.01978 540 PHE B CA  
3550 C C   A PHE B 17  ? 0.29577 0.28457 0.24771 0.03815  -0.02202 -0.01475 540 PHE B C   
3551 C C   B PHE B 17  ? 0.29602 0.28478 0.24796 0.03816  -0.02202 -0.01478 540 PHE B C   
3552 O O   A PHE B 17  ? 0.28290 0.27873 0.22404 0.02453  -0.02733 -0.02590 540 PHE B O   
3553 O O   B PHE B 17  ? 0.28435 0.28002 0.22547 0.02456  -0.02735 -0.02599 540 PHE B O   
3554 C CB  A PHE B 17  ? 0.26720 0.18905 0.21946 0.03706  -0.01840 -0.04762 540 PHE B CB  
3555 C CB  B PHE B 17  ? 0.27804 0.19988 0.23030 0.03706  -0.01840 -0.04762 540 PHE B CB  
3556 C CG  A PHE B 17  ? 0.34659 0.26659 0.28282 0.03346  -0.02416 -0.05401 540 PHE B CG  
3557 C CG  B PHE B 17  ? 0.34270 0.26269 0.27894 0.03344  -0.02416 -0.05402 540 PHE B CG  
3558 C CD1 A PHE B 17  ? 0.35854 0.25740 0.28944 0.03071  -0.00920 -0.05818 540 PHE B CD1 
3559 C CD1 B PHE B 17  ? 0.36088 0.25980 0.29181 0.03030  -0.00930 -0.05836 540 PHE B CD1 
3560 C CD2 A PHE B 17  ? 0.35412 0.29739 0.29089 0.02719  -0.03354 -0.04968 540 PHE B CD2 
3561 C CD2 B PHE B 17  ? 0.35742 0.30075 0.29403 0.02734  -0.03352 -0.04965 540 PHE B CD2 
3562 C CE1 A PHE B 17  ? 0.36394 0.27028 0.28520 0.02303  -0.01184 -0.05985 540 PHE B CE1 
3563 C CE1 B PHE B 17  ? 0.36534 0.27177 0.28664 0.02263  -0.01193 -0.06000 540 PHE B CE1 
3564 C CE2 A PHE B 17  ? 0.32757 0.27476 0.26078 0.02282  -0.03344 -0.04711 540 PHE B CE2 
3565 C CE2 B PHE B 17  ? 0.32673 0.27395 0.25983 0.02294  -0.03341 -0.04708 540 PHE B CE2 
3566 C CZ  A PHE B 17  ? 0.37218 0.30435 0.29536 0.02089  -0.02649 -0.05205 540 PHE B CZ  
3567 C CZ  B PHE B 17  ? 0.37387 0.30602 0.29707 0.02084  -0.02649 -0.05207 540 PHE B CZ  
3586 N N   . GLN B 18  ? 0.29474 0.30528 0.24637 0.04233  -0.02145 0.00069  541 GLN B N   
3587 C CA  . GLN B 18  ? 0.30156 0.35317 0.23452 0.02545  -0.03162 0.00543  541 GLN B CA  
3588 C C   . GLN B 18  ? 0.19957 0.22664 0.11188 0.02138  -0.03709 -0.01965 541 GLN B C   
3589 O O   . GLN B 18  ? 0.27172 0.27700 0.18698 0.03392  -0.03490 -0.02247 541 GLN B O   
3590 C CB  . GLN B 18  ? 0.31520 0.42206 0.26770 0.02959  -0.02974 0.04693  541 GLN B CB  
3591 C CG  . GLN B 18  ? 0.30341 0.43735 0.29187 0.04159  -0.01974 0.08588  541 GLN B CG  
3592 C CD  . GLN B 18  ? 0.29709 0.46195 0.26914 0.01722  -0.02800 0.08747  541 GLN B CD  
3593 O OE1 . GLN B 18  ? 0.36961 0.50905 0.35033 0.02394  -0.02103 0.08281  541 GLN B OE1 
3594 N NE2 . GLN B 18  ? 0.36659 0.56510 0.32466 -0.01601 -0.03244 0.08072  541 GLN B NE2 
3603 N N   . LEU B 19  ? 0.36200 0.37754 0.26668 -0.00189 -0.03242 -0.02959 542 LEU B N   
3604 C CA  . LEU B 19  ? 0.22675 0.21957 0.13267 -0.00928 -0.02551 -0.03727 542 LEU B CA  
3605 C C   . LEU B 19  ? 0.34049 0.33257 0.23505 -0.00865 -0.02977 -0.03074 542 LEU B C   
3606 O O   . LEU B 19  ? 0.29363 0.27651 0.19059 -0.01224 -0.02508 -0.03319 542 LEU B O   
3607 C CB  . LEU B 19  ? 0.26090 0.22465 0.16146 -0.00973 -0.01906 -0.04590 542 LEU B CB  
3608 C CG  . LEU B 19  ? 0.21324 0.17701 0.13052 -0.00993 -0.01252 -0.05550 542 LEU B CG  
3609 C CD1 . LEU B 19  ? 0.44550 0.38932 0.36647 -0.00484 -0.00385 -0.06818 542 LEU B CD1 
3610 C CD2 . LEU B 19  ? 0.34797 0.30943 0.28776 0.00793  -0.02371 -0.05185 542 LEU B CD2 
3611 O OXT . LEU B 19  ? 0.18946 0.22252 0.08551 -0.01309 -0.03163 -0.02270 542 LEU B OXT 
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