data_8RSG
# 
_entry.id   8RSG 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8RSG         pdb_00008rsg 10.2210/pdb8rsg/pdb 
WWPDB D_1292135453 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-12-04 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8RSG 
_pdbx_database_status.recvd_initial_deposition_date   2024-01-24 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              ec.schulz@uke.de 
_pdbx_contact_author.name_first         Eike 
_pdbx_contact_author.name_last          Schulz 
_pdbx_contact_author.name_mi            C 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-1685-8605 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Bosman, R.'      1 0000-0002-9939-602X 
'Prester, A.'     2 0000-0003-2738-7682 
'von Soosten, L.' 3 0000-0001-7568-1013 
'Dibenedetto, S.' 4 ?                   
'Bartels, K.'     5 0000-0002-7980-1913 
'Sung, S.'        6 0000-0001-5820-4696 
'von Stetten, D.' 7 0000-0001-7906-9788 
'Mehrabi, P.'     8 0000-0003-3211-6959 
'Schulz, E.C.'    9 0000-0002-1685-8605 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Kapton-based HARE chips for fixed-target serial crystallography' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Bosman, R.'      1  0000-0001-5820-4696 
primary 'Prester, A.'     2  0000-0003-2738-7682 
primary 'von Soosten, L.' 3  0000-0001-7568-1013 
primary 'Dibenedetto, S.' 4  ?                   
primary 'Bartels, K.'     5  0000-0002-7980-1913 
primary 'Sung, S.'        6  0000-0001-5820-4696 
primary 'von Stetten, D.' 7  0000-0001-7906-9788 
primary 'Mehrabi, P.'     8  0000-0003-3211-6959 
primary 'Blatter, G.'     9  ?                   
primary 'Lu, G.'          10 ?                   
primary 'Bernhard, S.'    11 ?                   
primary 'Osbild, M.'      12 ?                   
primary 'Schulz, E.C.'    13 0000-0002-1685-8605 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     nat 'Proteinase K' 40364.902 1   3.4.21.64 ? ? ? 
2 non-polymer syn 'NITRATE ION'  62.005    1   ?         ? ? ? 
3 non-polymer syn 'CALCIUM ION'  40.078    1   ?         ? ? ? 
4 water       nat water          18.015    111 ?         ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Endopeptidase K,Tritirachium alkaline proteinase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MRLSVLLSLLPLALGAPAVEQRSEAAPLIEARGEMVANKYIVKFKEGSALSALDAAMEKISGKPDHVYKNVFSGFAATLD
ENMVRVLRAHPDVEYIEQDAVVTINAAQTNAPWGLARISSTSPGTSTYYYDESAGQGSCVYVIDTGIEASHPEFEGRAQM
VKTYYYSSRDGNGHGTHCAGTVGSRTYGVAKKTQLFGVKVLDDNGSGQYSTIIAGMDFVASDKNNRNCPKGVVASLSLGG
GYSSSVNSAAARLQSSGVMVAVAAGNNNADARNYSPASEPSVCTVGASDRYDRRSSFSNYGSVLDIFGPGTDILSTWIGG
STRSISGTSMATPHVAGLAAYLMTLGKTTAASACRYIADTANKGDLSNIPFGTVNLLAYNNYQA
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MRLSVLLSLLPLALGAPAVEQRSEAAPLIEARGEMVANKYIVKFKEGSALSALDAAMEKISGKPDHVYKNVFSGFAATLD
ENMVRVLRAHPDVEYIEQDAVVTINAAQTNAPWGLARISSTSPGTSTYYYDESAGQGSCVYVIDTGIEASHPEFEGRAQM
VKTYYYSSRDGNGHGTHCAGTVGSRTYGVAKKTQLFGVKVLDDNGSGQYSTIIAGMDFVASDKNNRNCPKGVVASLSLGG
GYSSSVNSAAARLQSSGVMVAVAAGNNNADARNYSPASEPSVCTVGASDRYDRRSSFSNYGSVLDIFGPGTDILSTWIGG
STRSISGTSMATPHVAGLAAYLMTLGKTTAASACRYIADTANKGDLSNIPFGTVNLLAYNNYQA
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'NITRATE ION' NO3 
3 'CALCIUM ION' CA  
4 water         HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ARG n 
1 3   LEU n 
1 4   SER n 
1 5   VAL n 
1 6   LEU n 
1 7   LEU n 
1 8   SER n 
1 9   LEU n 
1 10  LEU n 
1 11  PRO n 
1 12  LEU n 
1 13  ALA n 
1 14  LEU n 
1 15  GLY n 
1 16  ALA n 
1 17  PRO n 
1 18  ALA n 
1 19  VAL n 
1 20  GLU n 
1 21  GLN n 
1 22  ARG n 
1 23  SER n 
1 24  GLU n 
1 25  ALA n 
1 26  ALA n 
1 27  PRO n 
1 28  LEU n 
1 29  ILE n 
1 30  GLU n 
1 31  ALA n 
1 32  ARG n 
1 33  GLY n 
1 34  GLU n 
1 35  MET n 
1 36  VAL n 
1 37  ALA n 
1 38  ASN n 
1 39  LYS n 
1 40  TYR n 
1 41  ILE n 
1 42  VAL n 
1 43  LYS n 
1 44  PHE n 
1 45  LYS n 
1 46  GLU n 
1 47  GLY n 
1 48  SER n 
1 49  ALA n 
1 50  LEU n 
1 51  SER n 
1 52  ALA n 
1 53  LEU n 
1 54  ASP n 
1 55  ALA n 
1 56  ALA n 
1 57  MET n 
1 58  GLU n 
1 59  LYS n 
1 60  ILE n 
1 61  SER n 
1 62  GLY n 
1 63  LYS n 
1 64  PRO n 
1 65  ASP n 
1 66  HIS n 
1 67  VAL n 
1 68  TYR n 
1 69  LYS n 
1 70  ASN n 
1 71  VAL n 
1 72  PHE n 
1 73  SER n 
1 74  GLY n 
1 75  PHE n 
1 76  ALA n 
1 77  ALA n 
1 78  THR n 
1 79  LEU n 
1 80  ASP n 
1 81  GLU n 
1 82  ASN n 
1 83  MET n 
1 84  VAL n 
1 85  ARG n 
1 86  VAL n 
1 87  LEU n 
1 88  ARG n 
1 89  ALA n 
1 90  HIS n 
1 91  PRO n 
1 92  ASP n 
1 93  VAL n 
1 94  GLU n 
1 95  TYR n 
1 96  ILE n 
1 97  GLU n 
1 98  GLN n 
1 99  ASP n 
1 100 ALA n 
1 101 VAL n 
1 102 VAL n 
1 103 THR n 
1 104 ILE n 
1 105 ASN n 
1 106 ALA n 
1 107 ALA n 
1 108 GLN n 
1 109 THR n 
1 110 ASN n 
1 111 ALA n 
1 112 PRO n 
1 113 TRP n 
1 114 GLY n 
1 115 LEU n 
1 116 ALA n 
1 117 ARG n 
1 118 ILE n 
1 119 SER n 
1 120 SER n 
1 121 THR n 
1 122 SER n 
1 123 PRO n 
1 124 GLY n 
1 125 THR n 
1 126 SER n 
1 127 THR n 
1 128 TYR n 
1 129 TYR n 
1 130 TYR n 
1 131 ASP n 
1 132 GLU n 
1 133 SER n 
1 134 ALA n 
1 135 GLY n 
1 136 GLN n 
1 137 GLY n 
1 138 SER n 
1 139 CYS n 
1 140 VAL n 
1 141 TYR n 
1 142 VAL n 
1 143 ILE n 
1 144 ASP n 
1 145 THR n 
1 146 GLY n 
1 147 ILE n 
1 148 GLU n 
1 149 ALA n 
1 150 SER n 
1 151 HIS n 
1 152 PRO n 
1 153 GLU n 
1 154 PHE n 
1 155 GLU n 
1 156 GLY n 
1 157 ARG n 
1 158 ALA n 
1 159 GLN n 
1 160 MET n 
1 161 VAL n 
1 162 LYS n 
1 163 THR n 
1 164 TYR n 
1 165 TYR n 
1 166 TYR n 
1 167 SER n 
1 168 SER n 
1 169 ARG n 
1 170 ASP n 
1 171 GLY n 
1 172 ASN n 
1 173 GLY n 
1 174 HIS n 
1 175 GLY n 
1 176 THR n 
1 177 HIS n 
1 178 CYS n 
1 179 ALA n 
1 180 GLY n 
1 181 THR n 
1 182 VAL n 
1 183 GLY n 
1 184 SER n 
1 185 ARG n 
1 186 THR n 
1 187 TYR n 
1 188 GLY n 
1 189 VAL n 
1 190 ALA n 
1 191 LYS n 
1 192 LYS n 
1 193 THR n 
1 194 GLN n 
1 195 LEU n 
1 196 PHE n 
1 197 GLY n 
1 198 VAL n 
1 199 LYS n 
1 200 VAL n 
1 201 LEU n 
1 202 ASP n 
1 203 ASP n 
1 204 ASN n 
1 205 GLY n 
1 206 SER n 
1 207 GLY n 
1 208 GLN n 
1 209 TYR n 
1 210 SER n 
1 211 THR n 
1 212 ILE n 
1 213 ILE n 
1 214 ALA n 
1 215 GLY n 
1 216 MET n 
1 217 ASP n 
1 218 PHE n 
1 219 VAL n 
1 220 ALA n 
1 221 SER n 
1 222 ASP n 
1 223 LYS n 
1 224 ASN n 
1 225 ASN n 
1 226 ARG n 
1 227 ASN n 
1 228 CYS n 
1 229 PRO n 
1 230 LYS n 
1 231 GLY n 
1 232 VAL n 
1 233 VAL n 
1 234 ALA n 
1 235 SER n 
1 236 LEU n 
1 237 SER n 
1 238 LEU n 
1 239 GLY n 
1 240 GLY n 
1 241 GLY n 
1 242 TYR n 
1 243 SER n 
1 244 SER n 
1 245 SER n 
1 246 VAL n 
1 247 ASN n 
1 248 SER n 
1 249 ALA n 
1 250 ALA n 
1 251 ALA n 
1 252 ARG n 
1 253 LEU n 
1 254 GLN n 
1 255 SER n 
1 256 SER n 
1 257 GLY n 
1 258 VAL n 
1 259 MET n 
1 260 VAL n 
1 261 ALA n 
1 262 VAL n 
1 263 ALA n 
1 264 ALA n 
1 265 GLY n 
1 266 ASN n 
1 267 ASN n 
1 268 ASN n 
1 269 ALA n 
1 270 ASP n 
1 271 ALA n 
1 272 ARG n 
1 273 ASN n 
1 274 TYR n 
1 275 SER n 
1 276 PRO n 
1 277 ALA n 
1 278 SER n 
1 279 GLU n 
1 280 PRO n 
1 281 SER n 
1 282 VAL n 
1 283 CYS n 
1 284 THR n 
1 285 VAL n 
1 286 GLY n 
1 287 ALA n 
1 288 SER n 
1 289 ASP n 
1 290 ARG n 
1 291 TYR n 
1 292 ASP n 
1 293 ARG n 
1 294 ARG n 
1 295 SER n 
1 296 SER n 
1 297 PHE n 
1 298 SER n 
1 299 ASN n 
1 300 TYR n 
1 301 GLY n 
1 302 SER n 
1 303 VAL n 
1 304 LEU n 
1 305 ASP n 
1 306 ILE n 
1 307 PHE n 
1 308 GLY n 
1 309 PRO n 
1 310 GLY n 
1 311 THR n 
1 312 ASP n 
1 313 ILE n 
1 314 LEU n 
1 315 SER n 
1 316 THR n 
1 317 TRP n 
1 318 ILE n 
1 319 GLY n 
1 320 GLY n 
1 321 SER n 
1 322 THR n 
1 323 ARG n 
1 324 SER n 
1 325 ILE n 
1 326 SER n 
1 327 GLY n 
1 328 THR n 
1 329 SER n 
1 330 MET n 
1 331 ALA n 
1 332 THR n 
1 333 PRO n 
1 334 HIS n 
1 335 VAL n 
1 336 ALA n 
1 337 GLY n 
1 338 LEU n 
1 339 ALA n 
1 340 ALA n 
1 341 TYR n 
1 342 LEU n 
1 343 MET n 
1 344 THR n 
1 345 LEU n 
1 346 GLY n 
1 347 LYS n 
1 348 THR n 
1 349 THR n 
1 350 ALA n 
1 351 ALA n 
1 352 SER n 
1 353 ALA n 
1 354 CYS n 
1 355 ARG n 
1 356 TYR n 
1 357 ILE n 
1 358 ALA n 
1 359 ASP n 
1 360 THR n 
1 361 ALA n 
1 362 ASN n 
1 363 LYS n 
1 364 GLY n 
1 365 ASP n 
1 366 LEU n 
1 367 SER n 
1 368 ASN n 
1 369 ILE n 
1 370 PRO n 
1 371 PHE n 
1 372 GLY n 
1 373 THR n 
1 374 VAL n 
1 375 ASN n 
1 376 LEU n 
1 377 LEU n 
1 378 ALA n 
1 379 TYR n 
1 380 ASN n 
1 381 ASN n 
1 382 TYR n 
1 383 GLN n 
1 384 ALA n 
# 
_entity_src_nat.entity_id                  1 
_entity_src_nat.pdbx_src_id                1 
_entity_src_nat.pdbx_alt_source_flag       sample 
_entity_src_nat.pdbx_beg_seq_num           1 
_entity_src_nat.pdbx_end_seq_num           384 
_entity_src_nat.common_name                ? 
_entity_src_nat.pdbx_organism_scientific   'Parengyodontium album' 
_entity_src_nat.pdbx_ncbi_taxonomy_id      37998 
_entity_src_nat.genus                      ? 
_entity_src_nat.species                    ? 
_entity_src_nat.strain                     ? 
_entity_src_nat.tissue                     ? 
_entity_src_nat.tissue_fraction            ? 
_entity_src_nat.pdbx_secretion             ? 
_entity_src_nat.pdbx_fragment              ? 
_entity_src_nat.pdbx_variant               ? 
_entity_src_nat.pdbx_cell_line             ? 
_entity_src_nat.pdbx_atcc                  ? 
_entity_src_nat.pdbx_cellular_location     ? 
_entity_src_nat.pdbx_organ                 ? 
_entity_src_nat.pdbx_organelle             ? 
_entity_src_nat.pdbx_cell                  ? 
_entity_src_nat.pdbx_plasmid_name          ? 
_entity_src_nat.pdbx_plasmid_details       ? 
_entity_src_nat.details                    ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CA  non-polymer         . 'CALCIUM ION'   ? 'Ca 2'           40.078  
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
NO3 non-polymer         . 'NITRATE ION'   ? 'N O3 -1'        62.005  
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -104 ?   ?   ?   A . n 
A 1 2   ARG 2   -103 ?   ?   ?   A . n 
A 1 3   LEU 3   -102 ?   ?   ?   A . n 
A 1 4   SER 4   -101 ?   ?   ?   A . n 
A 1 5   VAL 5   -100 ?   ?   ?   A . n 
A 1 6   LEU 6   -99  ?   ?   ?   A . n 
A 1 7   LEU 7   -98  ?   ?   ?   A . n 
A 1 8   SER 8   -97  ?   ?   ?   A . n 
A 1 9   LEU 9   -96  ?   ?   ?   A . n 
A 1 10  LEU 10  -95  ?   ?   ?   A . n 
A 1 11  PRO 11  -94  ?   ?   ?   A . n 
A 1 12  LEU 12  -93  ?   ?   ?   A . n 
A 1 13  ALA 13  -92  ?   ?   ?   A . n 
A 1 14  LEU 14  -91  ?   ?   ?   A . n 
A 1 15  GLY 15  -90  ?   ?   ?   A . n 
A 1 16  ALA 16  -89  ?   ?   ?   A . n 
A 1 17  PRO 17  -88  ?   ?   ?   A . n 
A 1 18  ALA 18  -87  ?   ?   ?   A . n 
A 1 19  VAL 19  -86  ?   ?   ?   A . n 
A 1 20  GLU 20  -85  ?   ?   ?   A . n 
A 1 21  GLN 21  -84  ?   ?   ?   A . n 
A 1 22  ARG 22  -83  ?   ?   ?   A . n 
A 1 23  SER 23  -82  ?   ?   ?   A . n 
A 1 24  GLU 24  -81  ?   ?   ?   A . n 
A 1 25  ALA 25  -80  ?   ?   ?   A . n 
A 1 26  ALA 26  -79  ?   ?   ?   A . n 
A 1 27  PRO 27  -78  ?   ?   ?   A . n 
A 1 28  LEU 28  -77  ?   ?   ?   A . n 
A 1 29  ILE 29  -76  ?   ?   ?   A . n 
A 1 30  GLU 30  -75  ?   ?   ?   A . n 
A 1 31  ALA 31  -74  ?   ?   ?   A . n 
A 1 32  ARG 32  -73  ?   ?   ?   A . n 
A 1 33  GLY 33  -72  ?   ?   ?   A . n 
A 1 34  GLU 34  -71  ?   ?   ?   A . n 
A 1 35  MET 35  -70  ?   ?   ?   A . n 
A 1 36  VAL 36  -69  ?   ?   ?   A . n 
A 1 37  ALA 37  -68  ?   ?   ?   A . n 
A 1 38  ASN 38  -67  ?   ?   ?   A . n 
A 1 39  LYS 39  -66  ?   ?   ?   A . n 
A 1 40  TYR 40  -65  ?   ?   ?   A . n 
A 1 41  ILE 41  -64  ?   ?   ?   A . n 
A 1 42  VAL 42  -63  ?   ?   ?   A . n 
A 1 43  LYS 43  -62  ?   ?   ?   A . n 
A 1 44  PHE 44  -61  ?   ?   ?   A . n 
A 1 45  LYS 45  -60  ?   ?   ?   A . n 
A 1 46  GLU 46  -59  ?   ?   ?   A . n 
A 1 47  GLY 47  -58  ?   ?   ?   A . n 
A 1 48  SER 48  -57  ?   ?   ?   A . n 
A 1 49  ALA 49  -56  ?   ?   ?   A . n 
A 1 50  LEU 50  -55  ?   ?   ?   A . n 
A 1 51  SER 51  -54  ?   ?   ?   A . n 
A 1 52  ALA 52  -53  ?   ?   ?   A . n 
A 1 53  LEU 53  -52  ?   ?   ?   A . n 
A 1 54  ASP 54  -51  ?   ?   ?   A . n 
A 1 55  ALA 55  -50  ?   ?   ?   A . n 
A 1 56  ALA 56  -49  ?   ?   ?   A . n 
A 1 57  MET 57  -48  ?   ?   ?   A . n 
A 1 58  GLU 58  -47  ?   ?   ?   A . n 
A 1 59  LYS 59  -46  ?   ?   ?   A . n 
A 1 60  ILE 60  -45  ?   ?   ?   A . n 
A 1 61  SER 61  -44  ?   ?   ?   A . n 
A 1 62  GLY 62  -43  ?   ?   ?   A . n 
A 1 63  LYS 63  -42  ?   ?   ?   A . n 
A 1 64  PRO 64  -41  ?   ?   ?   A . n 
A 1 65  ASP 65  -40  ?   ?   ?   A . n 
A 1 66  HIS 66  -39  ?   ?   ?   A . n 
A 1 67  VAL 67  -38  ?   ?   ?   A . n 
A 1 68  TYR 68  -37  ?   ?   ?   A . n 
A 1 69  LYS 69  -36  ?   ?   ?   A . n 
A 1 70  ASN 70  -35  ?   ?   ?   A . n 
A 1 71  VAL 71  -34  ?   ?   ?   A . n 
A 1 72  PHE 72  -33  ?   ?   ?   A . n 
A 1 73  SER 73  -32  ?   ?   ?   A . n 
A 1 74  GLY 74  -31  ?   ?   ?   A . n 
A 1 75  PHE 75  -30  ?   ?   ?   A . n 
A 1 76  ALA 76  -29  ?   ?   ?   A . n 
A 1 77  ALA 77  -28  ?   ?   ?   A . n 
A 1 78  THR 78  -27  ?   ?   ?   A . n 
A 1 79  LEU 79  -26  ?   ?   ?   A . n 
A 1 80  ASP 80  -25  ?   ?   ?   A . n 
A 1 81  GLU 81  -24  ?   ?   ?   A . n 
A 1 82  ASN 82  -23  ?   ?   ?   A . n 
A 1 83  MET 83  -22  ?   ?   ?   A . n 
A 1 84  VAL 84  -21  ?   ?   ?   A . n 
A 1 85  ARG 85  -20  ?   ?   ?   A . n 
A 1 86  VAL 86  -19  ?   ?   ?   A . n 
A 1 87  LEU 87  -18  ?   ?   ?   A . n 
A 1 88  ARG 88  -17  ?   ?   ?   A . n 
A 1 89  ALA 89  -16  ?   ?   ?   A . n 
A 1 90  HIS 90  -15  ?   ?   ?   A . n 
A 1 91  PRO 91  -14  ?   ?   ?   A . n 
A 1 92  ASP 92  -13  ?   ?   ?   A . n 
A 1 93  VAL 93  -12  ?   ?   ?   A . n 
A 1 94  GLU 94  -11  ?   ?   ?   A . n 
A 1 95  TYR 95  -10  ?   ?   ?   A . n 
A 1 96  ILE 96  -9   ?   ?   ?   A . n 
A 1 97  GLU 97  -8   ?   ?   ?   A . n 
A 1 98  GLN 98  -7   ?   ?   ?   A . n 
A 1 99  ASP 99  -6   ?   ?   ?   A . n 
A 1 100 ALA 100 -5   ?   ?   ?   A . n 
A 1 101 VAL 101 -4   ?   ?   ?   A . n 
A 1 102 VAL 102 -3   ?   ?   ?   A . n 
A 1 103 THR 103 -2   ?   ?   ?   A . n 
A 1 104 ILE 104 -1   ?   ?   ?   A . n 
A 1 105 ASN 105 0    ?   ?   ?   A . n 
A 1 106 ALA 106 1    1   ALA ALA A . n 
A 1 107 ALA 107 2    2   ALA ALA A . n 
A 1 108 GLN 108 3    3   GLN GLN A . n 
A 1 109 THR 109 4    4   THR THR A . n 
A 1 110 ASN 110 5    5   ASN ASN A . n 
A 1 111 ALA 111 6    6   ALA ALA A . n 
A 1 112 PRO 112 7    7   PRO PRO A . n 
A 1 113 TRP 113 8    8   TRP TRP A . n 
A 1 114 GLY 114 9    9   GLY GLY A . n 
A 1 115 LEU 115 10   10  LEU LEU A . n 
A 1 116 ALA 116 11   11  ALA ALA A . n 
A 1 117 ARG 117 12   12  ARG ARG A . n 
A 1 118 ILE 118 13   13  ILE ILE A . n 
A 1 119 SER 119 14   14  SER SER A . n 
A 1 120 SER 120 15   15  SER SER A . n 
A 1 121 THR 121 16   16  THR THR A . n 
A 1 122 SER 122 17   17  SER SER A . n 
A 1 123 PRO 123 18   18  PRO PRO A . n 
A 1 124 GLY 124 19   19  GLY GLY A . n 
A 1 125 THR 125 20   20  THR THR A . n 
A 1 126 SER 126 21   21  SER SER A . n 
A 1 127 THR 127 22   22  THR THR A . n 
A 1 128 TYR 128 23   23  TYR TYR A . n 
A 1 129 TYR 129 24   24  TYR TYR A . n 
A 1 130 TYR 130 25   25  TYR TYR A . n 
A 1 131 ASP 131 26   26  ASP ASP A . n 
A 1 132 GLU 132 27   27  GLU GLU A . n 
A 1 133 SER 133 28   28  SER SER A . n 
A 1 134 ALA 134 29   29  ALA ALA A . n 
A 1 135 GLY 135 30   30  GLY GLY A . n 
A 1 136 GLN 136 31   31  GLN GLN A . n 
A 1 137 GLY 137 32   32  GLY GLY A . n 
A 1 138 SER 138 33   33  SER SER A . n 
A 1 139 CYS 139 34   34  CYS CYS A . n 
A 1 140 VAL 140 35   35  VAL VAL A . n 
A 1 141 TYR 141 36   36  TYR TYR A . n 
A 1 142 VAL 142 37   37  VAL VAL A . n 
A 1 143 ILE 143 38   38  ILE ILE A . n 
A 1 144 ASP 144 39   39  ASP ASP A . n 
A 1 145 THR 145 40   40  THR THR A . n 
A 1 146 GLY 146 41   41  GLY GLY A . n 
A 1 147 ILE 147 42   42  ILE ILE A . n 
A 1 148 GLU 148 43   43  GLU GLU A . n 
A 1 149 ALA 149 44   44  ALA ALA A . n 
A 1 150 SER 150 45   45  SER SER A . n 
A 1 151 HIS 151 46   46  HIS HIS A . n 
A 1 152 PRO 152 47   47  PRO PRO A . n 
A 1 153 GLU 153 48   48  GLU GLU A . n 
A 1 154 PHE 154 49   49  PHE PHE A . n 
A 1 155 GLU 155 50   50  GLU GLU A . n 
A 1 156 GLY 156 51   51  GLY GLY A . n 
A 1 157 ARG 157 52   52  ARG ARG A . n 
A 1 158 ALA 158 53   53  ALA ALA A . n 
A 1 159 GLN 159 54   54  GLN GLN A . n 
A 1 160 MET 160 55   55  MET MET A . n 
A 1 161 VAL 161 56   56  VAL VAL A . n 
A 1 162 LYS 162 57   57  LYS LYS A . n 
A 1 163 THR 163 58   58  THR THR A . n 
A 1 164 TYR 164 59   59  TYR TYR A . n 
A 1 165 TYR 165 60   60  TYR TYR A . n 
A 1 166 TYR 166 61   61  TYR TYR A . n 
A 1 167 SER 167 62   62  SER SER A . n 
A 1 168 SER 168 63   63  SER SER A . n 
A 1 169 ARG 169 64   64  ARG ARG A . n 
A 1 170 ASP 170 65   65  ASP ASP A . n 
A 1 171 GLY 171 66   66  GLY GLY A . n 
A 1 172 ASN 172 67   67  ASN ASN A . n 
A 1 173 GLY 173 68   68  GLY GLY A . n 
A 1 174 HIS 174 69   69  HIS HIS A . n 
A 1 175 GLY 175 70   70  GLY GLY A . n 
A 1 176 THR 176 71   71  THR THR A . n 
A 1 177 HIS 177 72   72  HIS HIS A . n 
A 1 178 CYS 178 73   73  CYS CYS A . n 
A 1 179 ALA 179 74   74  ALA ALA A . n 
A 1 180 GLY 180 75   75  GLY GLY A . n 
A 1 181 THR 181 76   76  THR THR A . n 
A 1 182 VAL 182 77   77  VAL VAL A . n 
A 1 183 GLY 183 78   78  GLY GLY A . n 
A 1 184 SER 184 79   79  SER SER A . n 
A 1 185 ARG 185 80   80  ARG ARG A . n 
A 1 186 THR 186 81   81  THR THR A . n 
A 1 187 TYR 187 82   82  TYR TYR A . n 
A 1 188 GLY 188 83   83  GLY GLY A . n 
A 1 189 VAL 189 84   84  VAL VAL A . n 
A 1 190 ALA 190 85   85  ALA ALA A . n 
A 1 191 LYS 191 86   86  LYS LYS A . n 
A 1 192 LYS 192 87   87  LYS LYS A . n 
A 1 193 THR 193 88   88  THR THR A . n 
A 1 194 GLN 194 89   89  GLN GLN A . n 
A 1 195 LEU 195 90   90  LEU LEU A . n 
A 1 196 PHE 196 91   91  PHE PHE A . n 
A 1 197 GLY 197 92   92  GLY GLY A . n 
A 1 198 VAL 198 93   93  VAL VAL A . n 
A 1 199 LYS 199 94   94  LYS LYS A . n 
A 1 200 VAL 200 95   95  VAL VAL A . n 
A 1 201 LEU 201 96   96  LEU LEU A . n 
A 1 202 ASP 202 97   97  ASP ASP A . n 
A 1 203 ASP 203 98   98  ASP ASP A . n 
A 1 204 ASN 204 99   99  ASN ASN A . n 
A 1 205 GLY 205 100  100 GLY GLY A . n 
A 1 206 SER 206 101  101 SER SER A . n 
A 1 207 GLY 207 102  102 GLY GLY A . n 
A 1 208 GLN 208 103  103 GLN GLN A . n 
A 1 209 TYR 209 104  104 TYR TYR A . n 
A 1 210 SER 210 105  105 SER SER A . n 
A 1 211 THR 211 106  106 THR THR A . n 
A 1 212 ILE 212 107  107 ILE ILE A . n 
A 1 213 ILE 213 108  108 ILE ILE A . n 
A 1 214 ALA 214 109  109 ALA ALA A . n 
A 1 215 GLY 215 110  110 GLY GLY A . n 
A 1 216 MET 216 111  111 MET MET A . n 
A 1 217 ASP 217 112  112 ASP ASP A . n 
A 1 218 PHE 218 113  113 PHE PHE A . n 
A 1 219 VAL 219 114  114 VAL VAL A . n 
A 1 220 ALA 220 115  115 ALA ALA A . n 
A 1 221 SER 221 116  116 SER SER A . n 
A 1 222 ASP 222 117  117 ASP ASP A . n 
A 1 223 LYS 223 118  118 LYS LYS A . n 
A 1 224 ASN 224 119  119 ASN ASN A . n 
A 1 225 ASN 225 120  120 ASN ASN A . n 
A 1 226 ARG 226 121  121 ARG ARG A . n 
A 1 227 ASN 227 122  122 ASN ASN A . n 
A 1 228 CYS 228 123  123 CYS CYS A . n 
A 1 229 PRO 229 124  124 PRO PRO A . n 
A 1 230 LYS 230 125  125 LYS LYS A . n 
A 1 231 GLY 231 126  126 GLY GLY A . n 
A 1 232 VAL 232 127  127 VAL VAL A . n 
A 1 233 VAL 233 128  128 VAL VAL A . n 
A 1 234 ALA 234 129  129 ALA ALA A . n 
A 1 235 SER 235 130  130 SER SER A . n 
A 1 236 LEU 236 131  131 LEU LEU A . n 
A 1 237 SER 237 132  132 SER SER A . n 
A 1 238 LEU 238 133  133 LEU LEU A . n 
A 1 239 GLY 239 134  134 GLY GLY A . n 
A 1 240 GLY 240 135  135 GLY GLY A . n 
A 1 241 GLY 241 136  136 GLY GLY A . n 
A 1 242 TYR 242 137  137 TYR TYR A . n 
A 1 243 SER 243 138  138 SER SER A . n 
A 1 244 SER 244 139  139 SER SER A . n 
A 1 245 SER 245 140  140 SER SER A . n 
A 1 246 VAL 246 141  141 VAL VAL A . n 
A 1 247 ASN 247 142  142 ASN ASN A . n 
A 1 248 SER 248 143  143 SER SER A . n 
A 1 249 ALA 249 144  144 ALA ALA A . n 
A 1 250 ALA 250 145  145 ALA ALA A . n 
A 1 251 ALA 251 146  146 ALA ALA A . n 
A 1 252 ARG 252 147  147 ARG ARG A . n 
A 1 253 LEU 253 148  148 LEU LEU A . n 
A 1 254 GLN 254 149  149 GLN GLN A . n 
A 1 255 SER 255 150  150 SER SER A . n 
A 1 256 SER 256 151  151 SER SER A . n 
A 1 257 GLY 257 152  152 GLY GLY A . n 
A 1 258 VAL 258 153  153 VAL VAL A . n 
A 1 259 MET 259 154  154 MET MET A . n 
A 1 260 VAL 260 155  155 VAL VAL A . n 
A 1 261 ALA 261 156  156 ALA ALA A . n 
A 1 262 VAL 262 157  157 VAL VAL A . n 
A 1 263 ALA 263 158  158 ALA ALA A . n 
A 1 264 ALA 264 159  159 ALA ALA A . n 
A 1 265 GLY 265 160  160 GLY GLY A . n 
A 1 266 ASN 266 161  161 ASN ASN A . n 
A 1 267 ASN 267 162  162 ASN ASN A . n 
A 1 268 ASN 268 163  163 ASN ASN A . n 
A 1 269 ALA 269 164  164 ALA ALA A . n 
A 1 270 ASP 270 165  165 ASP ASP A . n 
A 1 271 ALA 271 166  166 ALA ALA A . n 
A 1 272 ARG 272 167  167 ARG ARG A . n 
A 1 273 ASN 273 168  168 ASN ASN A . n 
A 1 274 TYR 274 169  169 TYR TYR A . n 
A 1 275 SER 275 170  170 SER SER A . n 
A 1 276 PRO 276 171  171 PRO PRO A . n 
A 1 277 ALA 277 172  172 ALA ALA A . n 
A 1 278 SER 278 173  173 SER SER A . n 
A 1 279 GLU 279 174  174 GLU GLU A . n 
A 1 280 PRO 280 175  175 PRO PRO A . n 
A 1 281 SER 281 176  176 SER SER A . n 
A 1 282 VAL 282 177  177 VAL VAL A . n 
A 1 283 CYS 283 178  178 CYS CYS A . n 
A 1 284 THR 284 179  179 THR THR A . n 
A 1 285 VAL 285 180  180 VAL VAL A . n 
A 1 286 GLY 286 181  181 GLY GLY A . n 
A 1 287 ALA 287 182  182 ALA ALA A . n 
A 1 288 SER 288 183  183 SER SER A . n 
A 1 289 ASP 289 184  184 ASP ASP A . n 
A 1 290 ARG 290 185  185 ARG ARG A . n 
A 1 291 TYR 291 186  186 TYR TYR A . n 
A 1 292 ASP 292 187  187 ASP ASP A . n 
A 1 293 ARG 293 188  188 ARG ARG A . n 
A 1 294 ARG 294 189  189 ARG ARG A . n 
A 1 295 SER 295 190  190 SER SER A . n 
A 1 296 SER 296 191  191 SER SER A . n 
A 1 297 PHE 297 192  192 PHE PHE A . n 
A 1 298 SER 298 193  193 SER SER A . n 
A 1 299 ASN 299 194  194 ASN ASN A . n 
A 1 300 TYR 300 195  195 TYR TYR A . n 
A 1 301 GLY 301 196  196 GLY GLY A . n 
A 1 302 SER 302 197  197 SER SER A . n 
A 1 303 VAL 303 198  198 VAL VAL A . n 
A 1 304 LEU 304 199  199 LEU LEU A . n 
A 1 305 ASP 305 200  200 ASP ASP A . n 
A 1 306 ILE 306 201  201 ILE ILE A . n 
A 1 307 PHE 307 202  202 PHE PHE A . n 
A 1 308 GLY 308 203  203 GLY GLY A . n 
A 1 309 PRO 309 204  204 PRO PRO A . n 
A 1 310 GLY 310 205  205 GLY GLY A . n 
A 1 311 THR 311 206  206 THR THR A . n 
A 1 312 ASP 312 207  207 ASP ASP A . n 
A 1 313 ILE 313 208  208 ILE ILE A . n 
A 1 314 LEU 314 209  209 LEU LEU A . n 
A 1 315 SER 315 210  210 SER SER A . n 
A 1 316 THR 316 211  211 THR THR A . n 
A 1 317 TRP 317 212  212 TRP TRP A . n 
A 1 318 ILE 318 213  213 ILE ILE A . n 
A 1 319 GLY 319 214  214 GLY GLY A . n 
A 1 320 GLY 320 215  215 GLY GLY A . n 
A 1 321 SER 321 216  216 SER SER A . n 
A 1 322 THR 322 217  217 THR THR A . n 
A 1 323 ARG 323 218  218 ARG ARG A . n 
A 1 324 SER 324 219  219 SER SER A . n 
A 1 325 ILE 325 220  220 ILE ILE A . n 
A 1 326 SER 326 221  221 SER SER A . n 
A 1 327 GLY 327 222  222 GLY GLY A . n 
A 1 328 THR 328 223  223 THR THR A . n 
A 1 329 SER 329 224  224 SER SER A . n 
A 1 330 MET 330 225  225 MET MET A . n 
A 1 331 ALA 331 226  226 ALA ALA A . n 
A 1 332 THR 332 227  227 THR THR A . n 
A 1 333 PRO 333 228  228 PRO PRO A . n 
A 1 334 HIS 334 229  229 HIS HIS A . n 
A 1 335 VAL 335 230  230 VAL VAL A . n 
A 1 336 ALA 336 231  231 ALA ALA A . n 
A 1 337 GLY 337 232  232 GLY GLY A . n 
A 1 338 LEU 338 233  233 LEU LEU A . n 
A 1 339 ALA 339 234  234 ALA ALA A . n 
A 1 340 ALA 340 235  235 ALA ALA A . n 
A 1 341 TYR 341 236  236 TYR TYR A . n 
A 1 342 LEU 342 237  237 LEU LEU A . n 
A 1 343 MET 343 238  238 MET MET A . n 
A 1 344 THR 344 239  239 THR THR A . n 
A 1 345 LEU 345 240  240 LEU LEU A . n 
A 1 346 GLY 346 241  241 GLY GLY A . n 
A 1 347 LYS 347 242  242 LYS LYS A . n 
A 1 348 THR 348 243  243 THR THR A . n 
A 1 349 THR 349 244  244 THR THR A . n 
A 1 350 ALA 350 245  245 ALA ALA A . n 
A 1 351 ALA 351 246  246 ALA ALA A . n 
A 1 352 SER 352 247  247 SER SER A . n 
A 1 353 ALA 353 248  248 ALA ALA A . n 
A 1 354 CYS 354 249  249 CYS CYS A . n 
A 1 355 ARG 355 250  250 ARG ARG A . n 
A 1 356 TYR 356 251  251 TYR TYR A . n 
A 1 357 ILE 357 252  252 ILE ILE A . n 
A 1 358 ALA 358 253  253 ALA ALA A . n 
A 1 359 ASP 359 254  254 ASP ASP A . n 
A 1 360 THR 360 255  255 THR THR A . n 
A 1 361 ALA 361 256  256 ALA ALA A . n 
A 1 362 ASN 362 257  257 ASN ASN A . n 
A 1 363 LYS 363 258  258 LYS LYS A . n 
A 1 364 GLY 364 259  259 GLY GLY A . n 
A 1 365 ASP 365 260  260 ASP ASP A . n 
A 1 366 LEU 366 261  261 LEU LEU A . n 
A 1 367 SER 367 262  262 SER SER A . n 
A 1 368 ASN 368 263  263 ASN ASN A . n 
A 1 369 ILE 369 264  264 ILE ILE A . n 
A 1 370 PRO 370 265  265 PRO PRO A . n 
A 1 371 PHE 371 266  266 PHE PHE A . n 
A 1 372 GLY 372 267  267 GLY GLY A . n 
A 1 373 THR 373 268  268 THR THR A . n 
A 1 374 VAL 374 269  269 VAL VAL A . n 
A 1 375 ASN 375 270  270 ASN ASN A . n 
A 1 376 LEU 376 271  271 LEU LEU A . n 
A 1 377 LEU 377 272  272 LEU LEU A . n 
A 1 378 ALA 378 273  273 ALA ALA A . n 
A 1 379 TYR 379 274  274 TYR TYR A . n 
A 1 380 ASN 380 275  275 ASN ASN A . n 
A 1 381 ASN 381 276  276 ASN ASN A . n 
A 1 382 TYR 382 277  277 TYR TYR A . n 
A 1 383 GLN 383 278  278 GLN GLN A . n 
A 1 384 ALA 384 279  279 ALA ALA A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 NO3 1   301 301 NO3 NO3 A . 
C 3 CA  1   302 1   CA  CA  A . 
D 4 HOH 1   401 74  HOH HOH A . 
D 4 HOH 2   402 61  HOH HOH A . 
D 4 HOH 3   403 57  HOH HOH A . 
D 4 HOH 4   404 111 HOH HOH A . 
D 4 HOH 5   405 46  HOH HOH A . 
D 4 HOH 6   406 81  HOH HOH A . 
D 4 HOH 7   407 58  HOH HOH A . 
D 4 HOH 8   408 54  HOH HOH A . 
D 4 HOH 9   409 35  HOH HOH A . 
D 4 HOH 10  410 47  HOH HOH A . 
D 4 HOH 11  411 37  HOH HOH A . 
D 4 HOH 12  412 83  HOH HOH A . 
D 4 HOH 13  413 98  HOH HOH A . 
D 4 HOH 14  414 3   HOH HOH A . 
D 4 HOH 15  415 102 HOH HOH A . 
D 4 HOH 16  416 30  HOH HOH A . 
D 4 HOH 17  417 9   HOH HOH A . 
D 4 HOH 18  418 51  HOH HOH A . 
D 4 HOH 19  419 100 HOH HOH A . 
D 4 HOH 20  420 67  HOH HOH A . 
D 4 HOH 21  421 40  HOH HOH A . 
D 4 HOH 22  422 44  HOH HOH A . 
D 4 HOH 23  423 41  HOH HOH A . 
D 4 HOH 24  424 32  HOH HOH A . 
D 4 HOH 25  425 10  HOH HOH A . 
D 4 HOH 26  426 92  HOH HOH A . 
D 4 HOH 27  427 21  HOH HOH A . 
D 4 HOH 28  428 12  HOH HOH A . 
D 4 HOH 29  429 6   HOH HOH A . 
D 4 HOH 30  430 80  HOH HOH A . 
D 4 HOH 31  431 18  HOH HOH A . 
D 4 HOH 32  432 34  HOH HOH A . 
D 4 HOH 33  433 1   HOH HOH A . 
D 4 HOH 34  434 108 HOH HOH A . 
D 4 HOH 35  435 93  HOH HOH A . 
D 4 HOH 36  436 36  HOH HOH A . 
D 4 HOH 37  437 76  HOH HOH A . 
D 4 HOH 38  438 91  HOH HOH A . 
D 4 HOH 39  439 106 HOH HOH A . 
D 4 HOH 40  440 2   HOH HOH A . 
D 4 HOH 41  441 68  HOH HOH A . 
D 4 HOH 42  442 49  HOH HOH A . 
D 4 HOH 43  443 4   HOH HOH A . 
D 4 HOH 44  444 17  HOH HOH A . 
D 4 HOH 45  445 28  HOH HOH A . 
D 4 HOH 46  446 87  HOH HOH A . 
D 4 HOH 47  447 48  HOH HOH A . 
D 4 HOH 48  448 38  HOH HOH A . 
D 4 HOH 49  449 60  HOH HOH A . 
D 4 HOH 50  450 39  HOH HOH A . 
D 4 HOH 51  451 53  HOH HOH A . 
D 4 HOH 52  452 19  HOH HOH A . 
D 4 HOH 53  453 15  HOH HOH A . 
D 4 HOH 54  454 45  HOH HOH A . 
D 4 HOH 55  455 26  HOH HOH A . 
D 4 HOH 56  456 23  HOH HOH A . 
D 4 HOH 57  457 29  HOH HOH A . 
D 4 HOH 58  458 86  HOH HOH A . 
D 4 HOH 59  459 8   HOH HOH A . 
D 4 HOH 60  460 59  HOH HOH A . 
D 4 HOH 61  461 24  HOH HOH A . 
D 4 HOH 62  462 72  HOH HOH A . 
D 4 HOH 63  463 22  HOH HOH A . 
D 4 HOH 64  464 95  HOH HOH A . 
D 4 HOH 65  465 104 HOH HOH A . 
D 4 HOH 66  466 27  HOH HOH A . 
D 4 HOH 67  467 11  HOH HOH A . 
D 4 HOH 68  468 64  HOH HOH A . 
D 4 HOH 69  469 50  HOH HOH A . 
D 4 HOH 70  470 69  HOH HOH A . 
D 4 HOH 71  471 99  HOH HOH A . 
D 4 HOH 72  472 85  HOH HOH A . 
D 4 HOH 73  473 73  HOH HOH A . 
D 4 HOH 74  474 89  HOH HOH A . 
D 4 HOH 75  475 71  HOH HOH A . 
D 4 HOH 76  476 63  HOH HOH A . 
D 4 HOH 77  477 14  HOH HOH A . 
D 4 HOH 78  478 66  HOH HOH A . 
D 4 HOH 79  479 5   HOH HOH A . 
D 4 HOH 80  480 7   HOH HOH A . 
D 4 HOH 81  481 107 HOH HOH A . 
D 4 HOH 82  482 75  HOH HOH A . 
D 4 HOH 83  483 77  HOH HOH A . 
D 4 HOH 84  484 55  HOH HOH A . 
D 4 HOH 85  485 79  HOH HOH A . 
D 4 HOH 86  486 13  HOH HOH A . 
D 4 HOH 87  487 82  HOH HOH A . 
D 4 HOH 88  488 94  HOH HOH A . 
D 4 HOH 89  489 70  HOH HOH A . 
D 4 HOH 90  490 25  HOH HOH A . 
D 4 HOH 91  491 88  HOH HOH A . 
D 4 HOH 92  492 31  HOH HOH A . 
D 4 HOH 93  493 20  HOH HOH A . 
D 4 HOH 94  494 96  HOH HOH A . 
D 4 HOH 95  495 103 HOH HOH A . 
D 4 HOH 96  496 62  HOH HOH A . 
D 4 HOH 97  497 43  HOH HOH A . 
D 4 HOH 98  498 16  HOH HOH A . 
D 4 HOH 99  499 42  HOH HOH A . 
D 4 HOH 100 500 109 HOH HOH A . 
D 4 HOH 101 501 90  HOH HOH A . 
D 4 HOH 102 502 56  HOH HOH A . 
D 4 HOH 103 503 105 HOH HOH A . 
D 4 HOH 104 504 65  HOH HOH A . 
D 4 HOH 105 505 33  HOH HOH A . 
D 4 HOH 106 506 110 HOH HOH A . 
D 4 HOH 107 507 84  HOH HOH A . 
D 4 HOH 108 508 52  HOH HOH A . 
D 4 HOH 109 509 97  HOH HOH A . 
D 4 HOH 110 510 101 HOH HOH A . 
D 4 HOH 111 511 78  HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.20.1_4487 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? CrystFEL ? ? ? 0.10.2      2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? CrystFEL ? ? ? 0.10.2      3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 2.8.3       4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8RSG 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     68.500 
_cell.length_a_esd                 ? 
_cell.length_b                     68.500 
_cell.length_b_esd                 ? 
_cell.length_c                     108.750 
_cell.length_c_esd                 ? 
_cell.volume                       510282.188 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8RSG 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                96 
_symmetry.space_group_name_Hall            'P 4nw 2abw' 
_symmetry.space_group_name_H-M             'P 43 21 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8RSG 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             ? 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          ? 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'BATCH MODE' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
;Microcrystals were obtained by mixing proteinase K solution (60mg/ml) with precipitant solution 1M NaNO3, 0.1M sodium 
citrate pH 6.5, in a 5:1 ratio and left overnight at room temperature.
;
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     293 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   Y 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 4M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-05-04 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.976 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'PETRA III, EMBL c/o DESY BEAMLINE P14 (MX2)' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.976 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   'P14 (MX2)' 
_diffrn_source.pdbx_synchrotron_site       'PETRA III, EMBL c/o DESY' 
# 
_reflns.B_iso_Wilson_estimate                          11.57 
_reflns.entry_id                                       8RSG 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.66 
_reflns.d_resolution_low                               57.96 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     32848 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                1181.8 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          19.23 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.993 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   0.0591 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.66 
_reflns_shell.d_res_low                                     1.73 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           14.68 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2803 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.987 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  0.0727 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               12.66 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8RSG 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.66 
_refine.ls_d_res_low                             57.96 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     31323 
_refine.ls_number_reflns_R_free                  1551 
_refine.ls_number_reflns_R_work                  29772 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.96 
_refine.ls_percent_reflns_R_free                 4.95 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1460 
_refine.ls_R_factor_R_free                       0.1790 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1443 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 15.3324 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1294 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.66 
_refine_hist.d_res_low                        57.96 
_refine_hist.number_atoms_solvent             111 
_refine_hist.number_atoms_total               2148 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2032 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         5 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0159 ? 2266 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.3246 ? 3105 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0984 ? 339  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0129 ? 422  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 5.9117 ? 351  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.66 1.71  . . 148 2655 99.93  . . . . 0.1596 . . . . . . . . . . . 0.2167 
'X-RAY DIFFRACTION' 1.71 1.77  . . 120 2657 99.96  . . . . 0.1272 . . . . . . . . . . . 0.1703 
'X-RAY DIFFRACTION' 1.77 1.85  . . 135 2679 99.96  . . . . 0.1263 . . . . . . . . . . . 0.1626 
'X-RAY DIFFRACTION' 1.85 1.93  . . 133 2638 99.96  . . . . 0.1313 . . . . . . . . . . . 0.1627 
'X-RAY DIFFRACTION' 1.93 2.03  . . 148 2672 99.93  . . . . 0.1428 . . . . . . . . . . . 0.2137 
'X-RAY DIFFRACTION' 2.03 2.16  . . 158 2663 100.00 . . . . 0.1346 . . . . . . . . . . . 0.1688 
'X-RAY DIFFRACTION' 2.16 2.33  . . 135 2687 99.96  . . . . 0.1418 . . . . . . . . . . . 0.1913 
'X-RAY DIFFRACTION' 2.33 2.56  . . 138 2711 100.00 . . . . 0.1608 . . . . . . . . . . . 0.1781 
'X-RAY DIFFRACTION' 2.56 2.93  . . 143 2726 100.00 . . . . 0.1628 . . . . . . . . . . . 0.2130 
'X-RAY DIFFRACTION' 2.93 3.69  . . 132 2771 100.00 . . . . 0.1469 . . . . . . . . . . . 0.1626 
'X-RAY DIFFRACTION' 3.69 57.96 . . 161 2913 99.90  . . . . 0.1376 . . . . . . . . . . . 0.1627 
# 
_struct.entry_id                     8RSG 
_struct.title                        'Proteinase K measured via serial crystallography from a kapton HARE-chip (125 micron)' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8RSG 
_struct_keywords.text            'Proteinase K, Serine protease, Hydrolase' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    PRTK_PARAQ 
_struct_ref.pdbx_db_accession          P06873 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MRLSVLLSLLPLALGAPAVEQRSEAAPLIEARGEMVANKYIVKFKEGSALSALDAAMEKISGKPDHVYKNVFSGFAATLD
ENMVRVLRAHPDVEYIEQDAVVTINAAQTNAPWGLARISSTSPGTSTYYYDESAGQGSCVYVIDTGIEASHPEFEGRAQM
VKTYYYSSRDGNGHGTHCAGTVGSRTYGVAKKTQLFGVKVLDDNGSGQYSTIIAGMDFVASDKNNRNCPKGVVASLSLGG
GYSSSVNSAAARLQSSGVMVAVAAGNNNADARNYSPASEPSVCTVGASDRYDRRSSFSNYGSVLDIFGPGTSILSTWIGG
STRSISGTSMATPHVAGLAAYLMTLGKTTAASACRYIADTANKGDLSNIPFGTVNLLAYNNYQA
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8RSG 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 384 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P06873 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  384 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       -104 
_struct_ref_seq.pdbx_auth_seq_align_end       279 
# 
_struct_ref_seq_dif.align_id                     1 
_struct_ref_seq_dif.pdbx_pdb_id_code             8RSG 
_struct_ref_seq_dif.mon_id                       ASP 
_struct_ref_seq_dif.pdbx_pdb_strand_id           A 
_struct_ref_seq_dif.seq_num                      312 
_struct_ref_seq_dif.pdbx_pdb_ins_code            ? 
_struct_ref_seq_dif.pdbx_seq_db_name             UNP 
_struct_ref_seq_dif.pdbx_seq_db_accession_code   P06873 
_struct_ref_seq_dif.db_mon_id                    SER 
_struct_ref_seq_dif.pdbx_seq_db_seq_num          312 
_struct_ref_seq_dif.details                      conflict 
_struct_ref_seq_dif.pdbx_auth_seq_num            207 
_struct_ref_seq_dif.pdbx_ordinal                 1 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 270   ? 
1 MORE         -11   ? 
1 'SSA (A^2)'  10360 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 PRO A 112 ? SER A 119 ? PRO A 7   SER A 14  1 ? 8  
HELX_P HELX_P2 AA2 HIS A 151 ? GLU A 155 ? HIS A 46  GLU A 50  5 ? 5  
HELX_P HELX_P3 AA3 GLY A 173 ? SER A 184 ? GLY A 68  SER A 79  1 ? 12 
HELX_P HELX_P4 AA4 GLN A 208 ? LYS A 223 ? GLN A 103 LYS A 118 1 ? 16 
HELX_P HELX_P5 AA5 ASN A 224 ? ARG A 226 ? ASN A 119 ARG A 121 5 ? 3  
HELX_P HELX_P6 AA6 SER A 243 ? SER A 256 ? SER A 138 SER A 151 1 ? 14 
HELX_P HELX_P7 AA7 ASP A 270 ? ARG A 272 ? ASP A 165 ARG A 167 5 ? 3  
HELX_P HELX_P8 AA8 GLY A 327 ? LEU A 345 ? GLY A 222 LEU A 240 1 ? 19 
HELX_P HELX_P9 AA9 SER A 352 ? THR A 360 ? SER A 247 THR A 255 1 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? A CYS 139 SG  ? ? ? 1_555 A CYS 228 SG ? ? A CYS 34  A CYS 123 1_555 ? ? ? ? ? ? ? 2.017 ? ? 
disulf2 disulf ? ? A CYS 283 SG  ? ? ? 1_555 A CYS 354 SG ? ? A CYS 178 A CYS 249 1_555 ? ? ? ? ? ? ? 2.024 ? ? 
metalc1 metalc ? ? A PRO 280 O   ? ? ? 1_555 C CA  .   CA ? ? A PRO 175 A CA  302 1_555 ? ? ? ? ? ? ? 2.387 ? ? 
metalc2 metalc ? ? A VAL 282 O   ? ? ? 1_555 C CA  .   CA ? ? A VAL 177 A CA  302 1_555 ? ? ? ? ? ? ? 2.429 ? ? 
metalc3 metalc ? ? A ASP 305 OD1 ? ? ? 1_555 C CA  .   CA ? ? A ASP 200 A CA  302 1_555 ? ? ? ? ? ? ? 2.746 ? ? 
metalc4 metalc ? ? A ASP 305 OD2 ? ? ? 1_555 C CA  .   CA ? ? A ASP 200 A CA  302 1_555 ? ? ? ? ? ? ? 2.426 ? ? 
metalc5 metalc ? ? C CA  .   CA  ? ? ? 1_555 D HOH .   O  ? ? A CA  302 A HOH 402 1_555 ? ? ? ? ? ? ? 2.540 ? ? 
metalc6 metalc ? ? C CA  .   CA  ? ? ? 1_555 D HOH .   O  ? ? A CA  302 A HOH 449 1_555 ? ? ? ? ? ? ? 2.491 ? ? 
metalc7 metalc ? ? C CA  .   CA  ? ? ? 1_555 D HOH .   O  ? ? A CA  302 A HOH 476 1_555 ? ? ? ? ? ? ? 2.386 ? ? 
metalc8 metalc ? ? C CA  .   CA  ? ? ? 1_555 D HOH .   O  ? ? A CA  302 A HOH 496 1_555 ? ? ? ? ? ? ? 2.515 ? ? 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
metalc ? ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  O   ? A PRO 280 ? A PRO 175 ? 1_555 CA ? C CA . ? A CA 302 ? 1_555 O   ? A VAL 282 ? A VAL 177 ? 1_555 86.9  ? 
2  O   ? A PRO 280 ? A PRO 175 ? 1_555 CA ? C CA . ? A CA 302 ? 1_555 OD1 ? A ASP 305 ? A ASP 200 ? 1_555 151.7 ? 
3  O   ? A VAL 282 ? A VAL 177 ? 1_555 CA ? C CA . ? A CA 302 ? 1_555 OD1 ? A ASP 305 ? A ASP 200 ? 1_555 114.7 ? 
4  O   ? A PRO 280 ? A PRO 175 ? 1_555 CA ? C CA . ? A CA 302 ? 1_555 OD2 ? A ASP 305 ? A ASP 200 ? 1_555 158.1 ? 
5  O   ? A VAL 282 ? A VAL 177 ? 1_555 CA ? C CA . ? A CA 302 ? 1_555 OD2 ? A ASP 305 ? A ASP 200 ? 1_555 81.2  ? 
6  OD1 ? A ASP 305 ? A ASP 200 ? 1_555 CA ? C CA . ? A CA 302 ? 1_555 OD2 ? A ASP 305 ? A ASP 200 ? 1_555 49.6  ? 
7  O   ? A PRO 280 ? A PRO 175 ? 1_555 CA ? C CA . ? A CA 302 ? 1_555 O   ? D HOH .   ? A HOH 402 ? 1_555 93.5  ? 
8  O   ? A VAL 282 ? A VAL 177 ? 1_555 CA ? C CA . ? A CA 302 ? 1_555 O   ? D HOH .   ? A HOH 402 ? 1_555 145.8 ? 
9  OD1 ? A ASP 305 ? A ASP 200 ? 1_555 CA ? C CA . ? A CA 302 ? 1_555 O   ? D HOH .   ? A HOH 402 ? 1_555 78.9  ? 
10 OD2 ? A ASP 305 ? A ASP 200 ? 1_555 CA ? C CA . ? A CA 302 ? 1_555 O   ? D HOH .   ? A HOH 402 ? 1_555 86.3  ? 
11 O   ? A PRO 280 ? A PRO 175 ? 1_555 CA ? C CA . ? A CA 302 ? 1_555 O   ? D HOH .   ? A HOH 449 ? 1_555 80.7  ? 
12 O   ? A VAL 282 ? A VAL 177 ? 1_555 CA ? C CA . ? A CA 302 ? 1_555 O   ? D HOH .   ? A HOH 449 ? 1_555 74.4  ? 
13 OD1 ? A ASP 305 ? A ASP 200 ? 1_555 CA ? C CA . ? A CA 302 ? 1_555 O   ? D HOH .   ? A HOH 449 ? 1_555 121.4 ? 
14 OD2 ? A ASP 305 ? A ASP 200 ? 1_555 CA ? C CA . ? A CA 302 ? 1_555 O   ? D HOH .   ? A HOH 449 ? 1_555 78.5  ? 
15 O   ? D HOH .   ? A HOH 402 ? 1_555 CA ? C CA . ? A CA 302 ? 1_555 O   ? D HOH .   ? A HOH 449 ? 1_555 71.9  ? 
16 O   ? A PRO 280 ? A PRO 175 ? 1_555 CA ? C CA . ? A CA 302 ? 1_555 O   ? D HOH .   ? A HOH 476 ? 1_555 91.0  ? 
17 O   ? A VAL 282 ? A VAL 177 ? 1_555 CA ? C CA . ? A CA 302 ? 1_555 O   ? D HOH .   ? A HOH 476 ? 1_555 73.5  ? 
18 OD1 ? A ASP 305 ? A ASP 200 ? 1_555 CA ? C CA . ? A CA 302 ? 1_555 O   ? D HOH .   ? A HOH 476 ? 1_555 78.9  ? 
19 OD2 ? A ASP 305 ? A ASP 200 ? 1_555 CA ? C CA . ? A CA 302 ? 1_555 O   ? D HOH .   ? A HOH 476 ? 1_555 103.0 ? 
20 O   ? D HOH .   ? A HOH 402 ? 1_555 CA ? C CA . ? A CA 302 ? 1_555 O   ? D HOH .   ? A HOH 476 ? 1_555 140.7 ? 
21 O   ? D HOH .   ? A HOH 449 ? 1_555 CA ? C CA . ? A CA 302 ? 1_555 O   ? D HOH .   ? A HOH 476 ? 1_555 147.1 ? 
22 O   ? A PRO 280 ? A PRO 175 ? 1_555 CA ? C CA . ? A CA 302 ? 1_555 O   ? D HOH .   ? A HOH 496 ? 1_555 75.1  ? 
23 O   ? A VAL 282 ? A VAL 177 ? 1_555 CA ? C CA . ? A CA 302 ? 1_555 O   ? D HOH .   ? A HOH 496 ? 1_555 139.9 ? 
24 OD1 ? A ASP 305 ? A ASP 200 ? 1_555 CA ? C CA . ? A CA 302 ? 1_555 O   ? D HOH .   ? A HOH 496 ? 1_555 76.6  ? 
25 OD2 ? A ASP 305 ? A ASP 200 ? 1_555 CA ? C CA . ? A CA 302 ? 1_555 O   ? D HOH .   ? A HOH 496 ? 1_555 125.2 ? 
26 O   ? D HOH .   ? A HOH 402 ? 1_555 CA ? C CA . ? A CA 302 ? 1_555 O   ? D HOH .   ? A HOH 496 ? 1_555 72.1  ? 
27 O   ? D HOH .   ? A HOH 449 ? 1_555 CA ? C CA . ? A CA 302 ? 1_555 O   ? D HOH .   ? A HOH 496 ? 1_555 134.8 ? 
28 O   ? D HOH .   ? A HOH 476 ? 1_555 CA ? C CA . ? A CA 302 ? 1_555 O   ? D HOH .   ? A HOH 496 ? 1_555 71.4  ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 139 ? CYS A 228 ? CYS A 34  ? 1_555 CYS A 123 ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS A 283 ? CYS A 354 ? CYS A 178 ? 1_555 CYS A 249 ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          SER 
_struct_mon_prot_cis.label_seq_id           275 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           SER 
_struct_mon_prot_cis.auth_seq_id            170 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    276 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     171 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       0.43 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 2 ? 
AA2 ? 7 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
AA5 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? parallel      
AA2 3 4 ? parallel      
AA2 4 5 ? parallel      
AA2 5 6 ? parallel      
AA2 6 7 ? parallel      
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA5 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ALA A 107 ? GLN A 108 ? ALA A 2   GLN A 3   
AA1 2 TYR A 128 ? TYR A 129 ? TYR A 23  TYR A 24  
AA2 1 ALA A 158 ? THR A 163 ? ALA A 53  THR A 58  
AA2 2 GLN A 194 ? LYS A 199 ? GLN A 89  LYS A 94  
AA2 3 SER A 138 ? ASP A 144 ? SER A 33  ASP A 39  
AA2 4 GLY A 231 ? LEU A 236 ? GLY A 126 LEU A 131 
AA2 5 MET A 259 ? ALA A 263 ? MET A 154 ALA A 158 
AA2 6 CYS A 283 ? SER A 288 ? CYS A 178 SER A 183 
AA2 7 ILE A 306 ? PRO A 309 ? ILE A 201 PRO A 204 
AA3 1 GLY A 240 ? GLY A 241 ? GLY A 135 GLY A 136 
AA3 2 TYR A 274 ? SER A 275 ? TYR A 169 SER A 170 
AA4 1 ILE A 313 ? TRP A 317 ? ILE A 208 TRP A 212 
AA4 2 SER A 321 ? ILE A 325 ? SER A 216 ILE A 220 
AA5 1 ASN A 362 ? LYS A 363 ? ASN A 257 LYS A 258 
AA5 2 LEU A 376 ? LEU A 377 ? LEU A 271 LEU A 272 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N GLN A 108 ? N GLN A 3   O TYR A 128 ? O TYR A 23  
AA2 1 2 N GLN A 159 ? N GLN A 54  O GLY A 197 ? O GLY A 92  
AA2 2 3 O GLN A 194 ? O GLN A 89  N VAL A 140 ? N VAL A 35  
AA2 3 4 N TYR A 141 ? N TYR A 36  O VAL A 233 ? O VAL A 128 
AA2 4 5 N LEU A 236 ? N LEU A 131 O ALA A 261 ? O ALA A 156 
AA2 5 6 N VAL A 262 ? N VAL A 157 O CYS A 283 ? O CYS A 178 
AA2 6 7 N GLY A 286 ? N GLY A 181 O ILE A 306 ? O ILE A 201 
AA3 1 2 N GLY A 240 ? N GLY A 135 O SER A 275 ? O SER A 170 
AA4 1 2 N ILE A 313 ? N ILE A 208 O ILE A 325 ? O ILE A 220 
AA5 1 2 N ASN A 362 ? N ASN A 257 O LEU A 377 ? O LEU A 272 
# 
_pdbx_entry_details.entry_id                   8RSG 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 39  ? ? -169.71 -148.69 
2 1 TYR A 60  ? ? -127.72 -166.88 
3 1 ASP A 207 ? B 62.43   61.42   
4 1 SER A 216 ? A -110.91 -169.19 
5 1 ASN A 270 ? ? -112.53 78.56   
# 
_pdbx_struct_special_symmetry.id              1 
_pdbx_struct_special_symmetry.PDB_model_num   1 
_pdbx_struct_special_symmetry.auth_asym_id    A 
_pdbx_struct_special_symmetry.auth_comp_id    HOH 
_pdbx_struct_special_symmetry.auth_seq_id     444 
_pdbx_struct_special_symmetry.PDB_ins_code    ? 
_pdbx_struct_special_symmetry.label_asym_id   D 
_pdbx_struct_special_symmetry.label_comp_id   HOH 
_pdbx_struct_special_symmetry.label_seq_id    . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z               
2 -y+1/2,x+1/2,z+3/4  
3 y+1/2,-x+1/2,z+1/4  
4 x+1/2,-y+1/2,-z+1/4 
5 -x+1/2,y+1/2,-z+3/4 
6 -x,-y,z+1/2         
7 y,x,-z              
8 -y,-x,-z+1/2        
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A MET -104 ? A MET 1   
2   1 Y 1 A ARG -103 ? A ARG 2   
3   1 Y 1 A LEU -102 ? A LEU 3   
4   1 Y 1 A SER -101 ? A SER 4   
5   1 Y 1 A VAL -100 ? A VAL 5   
6   1 Y 1 A LEU -99  ? A LEU 6   
7   1 Y 1 A LEU -98  ? A LEU 7   
8   1 Y 1 A SER -97  ? A SER 8   
9   1 Y 1 A LEU -96  ? A LEU 9   
10  1 Y 1 A LEU -95  ? A LEU 10  
11  1 Y 1 A PRO -94  ? A PRO 11  
12  1 Y 1 A LEU -93  ? A LEU 12  
13  1 Y 1 A ALA -92  ? A ALA 13  
14  1 Y 1 A LEU -91  ? A LEU 14  
15  1 Y 1 A GLY -90  ? A GLY 15  
16  1 Y 1 A ALA -89  ? A ALA 16  
17  1 Y 1 A PRO -88  ? A PRO 17  
18  1 Y 1 A ALA -87  ? A ALA 18  
19  1 Y 1 A VAL -86  ? A VAL 19  
20  1 Y 1 A GLU -85  ? A GLU 20  
21  1 Y 1 A GLN -84  ? A GLN 21  
22  1 Y 1 A ARG -83  ? A ARG 22  
23  1 Y 1 A SER -82  ? A SER 23  
24  1 Y 1 A GLU -81  ? A GLU 24  
25  1 Y 1 A ALA -80  ? A ALA 25  
26  1 Y 1 A ALA -79  ? A ALA 26  
27  1 Y 1 A PRO -78  ? A PRO 27  
28  1 Y 1 A LEU -77  ? A LEU 28  
29  1 Y 1 A ILE -76  ? A ILE 29  
30  1 Y 1 A GLU -75  ? A GLU 30  
31  1 Y 1 A ALA -74  ? A ALA 31  
32  1 Y 1 A ARG -73  ? A ARG 32  
33  1 Y 1 A GLY -72  ? A GLY 33  
34  1 Y 1 A GLU -71  ? A GLU 34  
35  1 Y 1 A MET -70  ? A MET 35  
36  1 Y 1 A VAL -69  ? A VAL 36  
37  1 Y 1 A ALA -68  ? A ALA 37  
38  1 Y 1 A ASN -67  ? A ASN 38  
39  1 Y 1 A LYS -66  ? A LYS 39  
40  1 Y 1 A TYR -65  ? A TYR 40  
41  1 Y 1 A ILE -64  ? A ILE 41  
42  1 Y 1 A VAL -63  ? A VAL 42  
43  1 Y 1 A LYS -62  ? A LYS 43  
44  1 Y 1 A PHE -61  ? A PHE 44  
45  1 Y 1 A LYS -60  ? A LYS 45  
46  1 Y 1 A GLU -59  ? A GLU 46  
47  1 Y 1 A GLY -58  ? A GLY 47  
48  1 Y 1 A SER -57  ? A SER 48  
49  1 Y 1 A ALA -56  ? A ALA 49  
50  1 Y 1 A LEU -55  ? A LEU 50  
51  1 Y 1 A SER -54  ? A SER 51  
52  1 Y 1 A ALA -53  ? A ALA 52  
53  1 Y 1 A LEU -52  ? A LEU 53  
54  1 Y 1 A ASP -51  ? A ASP 54  
55  1 Y 1 A ALA -50  ? A ALA 55  
56  1 Y 1 A ALA -49  ? A ALA 56  
57  1 Y 1 A MET -48  ? A MET 57  
58  1 Y 1 A GLU -47  ? A GLU 58  
59  1 Y 1 A LYS -46  ? A LYS 59  
60  1 Y 1 A ILE -45  ? A ILE 60  
61  1 Y 1 A SER -44  ? A SER 61  
62  1 Y 1 A GLY -43  ? A GLY 62  
63  1 Y 1 A LYS -42  ? A LYS 63  
64  1 Y 1 A PRO -41  ? A PRO 64  
65  1 Y 1 A ASP -40  ? A ASP 65  
66  1 Y 1 A HIS -39  ? A HIS 66  
67  1 Y 1 A VAL -38  ? A VAL 67  
68  1 Y 1 A TYR -37  ? A TYR 68  
69  1 Y 1 A LYS -36  ? A LYS 69  
70  1 Y 1 A ASN -35  ? A ASN 70  
71  1 Y 1 A VAL -34  ? A VAL 71  
72  1 Y 1 A PHE -33  ? A PHE 72  
73  1 Y 1 A SER -32  ? A SER 73  
74  1 Y 1 A GLY -31  ? A GLY 74  
75  1 Y 1 A PHE -30  ? A PHE 75  
76  1 Y 1 A ALA -29  ? A ALA 76  
77  1 Y 1 A ALA -28  ? A ALA 77  
78  1 Y 1 A THR -27  ? A THR 78  
79  1 Y 1 A LEU -26  ? A LEU 79  
80  1 Y 1 A ASP -25  ? A ASP 80  
81  1 Y 1 A GLU -24  ? A GLU 81  
82  1 Y 1 A ASN -23  ? A ASN 82  
83  1 Y 1 A MET -22  ? A MET 83  
84  1 Y 1 A VAL -21  ? A VAL 84  
85  1 Y 1 A ARG -20  ? A ARG 85  
86  1 Y 1 A VAL -19  ? A VAL 86  
87  1 Y 1 A LEU -18  ? A LEU 87  
88  1 Y 1 A ARG -17  ? A ARG 88  
89  1 Y 1 A ALA -16  ? A ALA 89  
90  1 Y 1 A HIS -15  ? A HIS 90  
91  1 Y 1 A PRO -14  ? A PRO 91  
92  1 Y 1 A ASP -13  ? A ASP 92  
93  1 Y 1 A VAL -12  ? A VAL 93  
94  1 Y 1 A GLU -11  ? A GLU 94  
95  1 Y 1 A TYR -10  ? A TYR 95  
96  1 Y 1 A ILE -9   ? A ILE 96  
97  1 Y 1 A GLU -8   ? A GLU 97  
98  1 Y 1 A GLN -7   ? A GLN 98  
99  1 Y 1 A ASP -6   ? A ASP 99  
100 1 Y 1 A ALA -5   ? A ALA 100 
101 1 Y 1 A VAL -4   ? A VAL 101 
102 1 Y 1 A VAL -3   ? A VAL 102 
103 1 Y 1 A THR -2   ? A THR 103 
104 1 Y 1 A ILE -1   ? A ILE 104 
105 1 Y 1 A ASN 0    ? A ASN 105 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CA  CA   CA N N 74  
CYS N    N  N N 75  
CYS CA   C  N R 76  
CYS C    C  N N 77  
CYS O    O  N N 78  
CYS CB   C  N N 79  
CYS SG   S  N N 80  
CYS OXT  O  N N 81  
CYS H    H  N N 82  
CYS H2   H  N N 83  
CYS HA   H  N N 84  
CYS HB2  H  N N 85  
CYS HB3  H  N N 86  
CYS HG   H  N N 87  
CYS HXT  H  N N 88  
GLN N    N  N N 89  
GLN CA   C  N S 90  
GLN C    C  N N 91  
GLN O    O  N N 92  
GLN CB   C  N N 93  
GLN CG   C  N N 94  
GLN CD   C  N N 95  
GLN OE1  O  N N 96  
GLN NE2  N  N N 97  
GLN OXT  O  N N 98  
GLN H    H  N N 99  
GLN H2   H  N N 100 
GLN HA   H  N N 101 
GLN HB2  H  N N 102 
GLN HB3  H  N N 103 
GLN HG2  H  N N 104 
GLN HG3  H  N N 105 
GLN HE21 H  N N 106 
GLN HE22 H  N N 107 
GLN HXT  H  N N 108 
GLU N    N  N N 109 
GLU CA   C  N S 110 
GLU C    C  N N 111 
GLU O    O  N N 112 
GLU CB   C  N N 113 
GLU CG   C  N N 114 
GLU CD   C  N N 115 
GLU OE1  O  N N 116 
GLU OE2  O  N N 117 
GLU OXT  O  N N 118 
GLU H    H  N N 119 
GLU H2   H  N N 120 
GLU HA   H  N N 121 
GLU HB2  H  N N 122 
GLU HB3  H  N N 123 
GLU HG2  H  N N 124 
GLU HG3  H  N N 125 
GLU HE2  H  N N 126 
GLU HXT  H  N N 127 
GLY N    N  N N 128 
GLY CA   C  N N 129 
GLY C    C  N N 130 
GLY O    O  N N 131 
GLY OXT  O  N N 132 
GLY H    H  N N 133 
GLY H2   H  N N 134 
GLY HA2  H  N N 135 
GLY HA3  H  N N 136 
GLY HXT  H  N N 137 
HIS N    N  N N 138 
HIS CA   C  N S 139 
HIS C    C  N N 140 
HIS O    O  N N 141 
HIS CB   C  N N 142 
HIS CG   C  Y N 143 
HIS ND1  N  Y N 144 
HIS CD2  C  Y N 145 
HIS CE1  C  Y N 146 
HIS NE2  N  Y N 147 
HIS OXT  O  N N 148 
HIS H    H  N N 149 
HIS H2   H  N N 150 
HIS HA   H  N N 151 
HIS HB2  H  N N 152 
HIS HB3  H  N N 153 
HIS HD1  H  N N 154 
HIS HD2  H  N N 155 
HIS HE1  H  N N 156 
HIS HE2  H  N N 157 
HIS HXT  H  N N 158 
HOH O    O  N N 159 
HOH H1   H  N N 160 
HOH H2   H  N N 161 
ILE N    N  N N 162 
ILE CA   C  N S 163 
ILE C    C  N N 164 
ILE O    O  N N 165 
ILE CB   C  N S 166 
ILE CG1  C  N N 167 
ILE CG2  C  N N 168 
ILE CD1  C  N N 169 
ILE OXT  O  N N 170 
ILE H    H  N N 171 
ILE H2   H  N N 172 
ILE HA   H  N N 173 
ILE HB   H  N N 174 
ILE HG12 H  N N 175 
ILE HG13 H  N N 176 
ILE HG21 H  N N 177 
ILE HG22 H  N N 178 
ILE HG23 H  N N 179 
ILE HD11 H  N N 180 
ILE HD12 H  N N 181 
ILE HD13 H  N N 182 
ILE HXT  H  N N 183 
LEU N    N  N N 184 
LEU CA   C  N S 185 
LEU C    C  N N 186 
LEU O    O  N N 187 
LEU CB   C  N N 188 
LEU CG   C  N N 189 
LEU CD1  C  N N 190 
LEU CD2  C  N N 191 
LEU OXT  O  N N 192 
LEU H    H  N N 193 
LEU H2   H  N N 194 
LEU HA   H  N N 195 
LEU HB2  H  N N 196 
LEU HB3  H  N N 197 
LEU HG   H  N N 198 
LEU HD11 H  N N 199 
LEU HD12 H  N N 200 
LEU HD13 H  N N 201 
LEU HD21 H  N N 202 
LEU HD22 H  N N 203 
LEU HD23 H  N N 204 
LEU HXT  H  N N 205 
LYS N    N  N N 206 
LYS CA   C  N S 207 
LYS C    C  N N 208 
LYS O    O  N N 209 
LYS CB   C  N N 210 
LYS CG   C  N N 211 
LYS CD   C  N N 212 
LYS CE   C  N N 213 
LYS NZ   N  N N 214 
LYS OXT  O  N N 215 
LYS H    H  N N 216 
LYS H2   H  N N 217 
LYS HA   H  N N 218 
LYS HB2  H  N N 219 
LYS HB3  H  N N 220 
LYS HG2  H  N N 221 
LYS HG3  H  N N 222 
LYS HD2  H  N N 223 
LYS HD3  H  N N 224 
LYS HE2  H  N N 225 
LYS HE3  H  N N 226 
LYS HZ1  H  N N 227 
LYS HZ2  H  N N 228 
LYS HZ3  H  N N 229 
LYS HXT  H  N N 230 
MET N    N  N N 231 
MET CA   C  N S 232 
MET C    C  N N 233 
MET O    O  N N 234 
MET CB   C  N N 235 
MET CG   C  N N 236 
MET SD   S  N N 237 
MET CE   C  N N 238 
MET OXT  O  N N 239 
MET H    H  N N 240 
MET H2   H  N N 241 
MET HA   H  N N 242 
MET HB2  H  N N 243 
MET HB3  H  N N 244 
MET HG2  H  N N 245 
MET HG3  H  N N 246 
MET HE1  H  N N 247 
MET HE2  H  N N 248 
MET HE3  H  N N 249 
MET HXT  H  N N 250 
NO3 N    N  N N 251 
NO3 O1   O  N N 252 
NO3 O2   O  N N 253 
NO3 O3   O  N N 254 
PHE N    N  N N 255 
PHE CA   C  N S 256 
PHE C    C  N N 257 
PHE O    O  N N 258 
PHE CB   C  N N 259 
PHE CG   C  Y N 260 
PHE CD1  C  Y N 261 
PHE CD2  C  Y N 262 
PHE CE1  C  Y N 263 
PHE CE2  C  Y N 264 
PHE CZ   C  Y N 265 
PHE OXT  O  N N 266 
PHE H    H  N N 267 
PHE H2   H  N N 268 
PHE HA   H  N N 269 
PHE HB2  H  N N 270 
PHE HB3  H  N N 271 
PHE HD1  H  N N 272 
PHE HD2  H  N N 273 
PHE HE1  H  N N 274 
PHE HE2  H  N N 275 
PHE HZ   H  N N 276 
PHE HXT  H  N N 277 
PRO N    N  N N 278 
PRO CA   C  N S 279 
PRO C    C  N N 280 
PRO O    O  N N 281 
PRO CB   C  N N 282 
PRO CG   C  N N 283 
PRO CD   C  N N 284 
PRO OXT  O  N N 285 
PRO H    H  N N 286 
PRO HA   H  N N 287 
PRO HB2  H  N N 288 
PRO HB3  H  N N 289 
PRO HG2  H  N N 290 
PRO HG3  H  N N 291 
PRO HD2  H  N N 292 
PRO HD3  H  N N 293 
PRO HXT  H  N N 294 
SER N    N  N N 295 
SER CA   C  N S 296 
SER C    C  N N 297 
SER O    O  N N 298 
SER CB   C  N N 299 
SER OG   O  N N 300 
SER OXT  O  N N 301 
SER H    H  N N 302 
SER H2   H  N N 303 
SER HA   H  N N 304 
SER HB2  H  N N 305 
SER HB3  H  N N 306 
SER HG   H  N N 307 
SER HXT  H  N N 308 
THR N    N  N N 309 
THR CA   C  N S 310 
THR C    C  N N 311 
THR O    O  N N 312 
THR CB   C  N R 313 
THR OG1  O  N N 314 
THR CG2  C  N N 315 
THR OXT  O  N N 316 
THR H    H  N N 317 
THR H2   H  N N 318 
THR HA   H  N N 319 
THR HB   H  N N 320 
THR HG1  H  N N 321 
THR HG21 H  N N 322 
THR HG22 H  N N 323 
THR HG23 H  N N 324 
THR HXT  H  N N 325 
TRP N    N  N N 326 
TRP CA   C  N S 327 
TRP C    C  N N 328 
TRP O    O  N N 329 
TRP CB   C  N N 330 
TRP CG   C  Y N 331 
TRP CD1  C  Y N 332 
TRP CD2  C  Y N 333 
TRP NE1  N  Y N 334 
TRP CE2  C  Y N 335 
TRP CE3  C  Y N 336 
TRP CZ2  C  Y N 337 
TRP CZ3  C  Y N 338 
TRP CH2  C  Y N 339 
TRP OXT  O  N N 340 
TRP H    H  N N 341 
TRP H2   H  N N 342 
TRP HA   H  N N 343 
TRP HB2  H  N N 344 
TRP HB3  H  N N 345 
TRP HD1  H  N N 346 
TRP HE1  H  N N 347 
TRP HE3  H  N N 348 
TRP HZ2  H  N N 349 
TRP HZ3  H  N N 350 
TRP HH2  H  N N 351 
TRP HXT  H  N N 352 
TYR N    N  N N 353 
TYR CA   C  N S 354 
TYR C    C  N N 355 
TYR O    O  N N 356 
TYR CB   C  N N 357 
TYR CG   C  Y N 358 
TYR CD1  C  Y N 359 
TYR CD2  C  Y N 360 
TYR CE1  C  Y N 361 
TYR CE2  C  Y N 362 
TYR CZ   C  Y N 363 
TYR OH   O  N N 364 
TYR OXT  O  N N 365 
TYR H    H  N N 366 
TYR H2   H  N N 367 
TYR HA   H  N N 368 
TYR HB2  H  N N 369 
TYR HB3  H  N N 370 
TYR HD1  H  N N 371 
TYR HD2  H  N N 372 
TYR HE1  H  N N 373 
TYR HE2  H  N N 374 
TYR HH   H  N N 375 
TYR HXT  H  N N 376 
VAL N    N  N N 377 
VAL CA   C  N S 378 
VAL C    C  N N 379 
VAL O    O  N N 380 
VAL CB   C  N N 381 
VAL CG1  C  N N 382 
VAL CG2  C  N N 383 
VAL OXT  O  N N 384 
VAL H    H  N N 385 
VAL H2   H  N N 386 
VAL HA   H  N N 387 
VAL HB   H  N N 388 
VAL HG11 H  N N 389 
VAL HG12 H  N N 390 
VAL HG13 H  N N 391 
VAL HG21 H  N N 392 
VAL HG22 H  N N 393 
VAL HG23 H  N N 394 
VAL HXT  H  N N 395 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
NO3 N   O1   doub N N 237 
NO3 N   O2   sing N N 238 
NO3 N   O3   sing N N 239 
PHE N   CA   sing N N 240 
PHE N   H    sing N N 241 
PHE N   H2   sing N N 242 
PHE CA  C    sing N N 243 
PHE CA  CB   sing N N 244 
PHE CA  HA   sing N N 245 
PHE C   O    doub N N 246 
PHE C   OXT  sing N N 247 
PHE CB  CG   sing N N 248 
PHE CB  HB2  sing N N 249 
PHE CB  HB3  sing N N 250 
PHE CG  CD1  doub Y N 251 
PHE CG  CD2  sing Y N 252 
PHE CD1 CE1  sing Y N 253 
PHE CD1 HD1  sing N N 254 
PHE CD2 CE2  doub Y N 255 
PHE CD2 HD2  sing N N 256 
PHE CE1 CZ   doub Y N 257 
PHE CE1 HE1  sing N N 258 
PHE CE2 CZ   sing Y N 259 
PHE CE2 HE2  sing N N 260 
PHE CZ  HZ   sing N N 261 
PHE OXT HXT  sing N N 262 
PRO N   CA   sing N N 263 
PRO N   CD   sing N N 264 
PRO N   H    sing N N 265 
PRO CA  C    sing N N 266 
PRO CA  CB   sing N N 267 
PRO CA  HA   sing N N 268 
PRO C   O    doub N N 269 
PRO C   OXT  sing N N 270 
PRO CB  CG   sing N N 271 
PRO CB  HB2  sing N N 272 
PRO CB  HB3  sing N N 273 
PRO CG  CD   sing N N 274 
PRO CG  HG2  sing N N 275 
PRO CG  HG3  sing N N 276 
PRO CD  HD2  sing N N 277 
PRO CD  HD3  sing N N 278 
PRO OXT HXT  sing N N 279 
SER N   CA   sing N N 280 
SER N   H    sing N N 281 
SER N   H2   sing N N 282 
SER CA  C    sing N N 283 
SER CA  CB   sing N N 284 
SER CA  HA   sing N N 285 
SER C   O    doub N N 286 
SER C   OXT  sing N N 287 
SER CB  OG   sing N N 288 
SER CB  HB2  sing N N 289 
SER CB  HB3  sing N N 290 
SER OG  HG   sing N N 291 
SER OXT HXT  sing N N 292 
THR N   CA   sing N N 293 
THR N   H    sing N N 294 
THR N   H2   sing N N 295 
THR CA  C    sing N N 296 
THR CA  CB   sing N N 297 
THR CA  HA   sing N N 298 
THR C   O    doub N N 299 
THR C   OXT  sing N N 300 
THR CB  OG1  sing N N 301 
THR CB  CG2  sing N N 302 
THR CB  HB   sing N N 303 
THR OG1 HG1  sing N N 304 
THR CG2 HG21 sing N N 305 
THR CG2 HG22 sing N N 306 
THR CG2 HG23 sing N N 307 
THR OXT HXT  sing N N 308 
TRP N   CA   sing N N 309 
TRP N   H    sing N N 310 
TRP N   H2   sing N N 311 
TRP CA  C    sing N N 312 
TRP CA  CB   sing N N 313 
TRP CA  HA   sing N N 314 
TRP C   O    doub N N 315 
TRP C   OXT  sing N N 316 
TRP CB  CG   sing N N 317 
TRP CB  HB2  sing N N 318 
TRP CB  HB3  sing N N 319 
TRP CG  CD1  doub Y N 320 
TRP CG  CD2  sing Y N 321 
TRP CD1 NE1  sing Y N 322 
TRP CD1 HD1  sing N N 323 
TRP CD2 CE2  doub Y N 324 
TRP CD2 CE3  sing Y N 325 
TRP NE1 CE2  sing Y N 326 
TRP NE1 HE1  sing N N 327 
TRP CE2 CZ2  sing Y N 328 
TRP CE3 CZ3  doub Y N 329 
TRP CE3 HE3  sing N N 330 
TRP CZ2 CH2  doub Y N 331 
TRP CZ2 HZ2  sing N N 332 
TRP CZ3 CH2  sing Y N 333 
TRP CZ3 HZ3  sing N N 334 
TRP CH2 HH2  sing N N 335 
TRP OXT HXT  sing N N 336 
TYR N   CA   sing N N 337 
TYR N   H    sing N N 338 
TYR N   H2   sing N N 339 
TYR CA  C    sing N N 340 
TYR CA  CB   sing N N 341 
TYR CA  HA   sing N N 342 
TYR C   O    doub N N 343 
TYR C   OXT  sing N N 344 
TYR CB  CG   sing N N 345 
TYR CB  HB2  sing N N 346 
TYR CB  HB3  sing N N 347 
TYR CG  CD1  doub Y N 348 
TYR CG  CD2  sing Y N 349 
TYR CD1 CE1  sing Y N 350 
TYR CD1 HD1  sing N N 351 
TYR CD2 CE2  doub Y N 352 
TYR CD2 HD2  sing N N 353 
TYR CE1 CZ   doub Y N 354 
TYR CE1 HE1  sing N N 355 
TYR CE2 CZ   sing Y N 356 
TYR CE2 HE2  sing N N 357 
TYR CZ  OH   sing N N 358 
TYR OH  HH   sing N N 359 
TYR OXT HXT  sing N N 360 
VAL N   CA   sing N N 361 
VAL N   H    sing N N 362 
VAL N   H2   sing N N 363 
VAL CA  C    sing N N 364 
VAL CA  CB   sing N N 365 
VAL CA  HA   sing N N 366 
VAL C   O    doub N N 367 
VAL C   OXT  sing N N 368 
VAL CB  CG1  sing N N 369 
VAL CB  CG2  sing N N 370 
VAL CB  HB   sing N N 371 
VAL CG1 HG11 sing N N 372 
VAL CG1 HG12 sing N N 373 
VAL CG1 HG13 sing N N 374 
VAL CG2 HG21 sing N N 375 
VAL CG2 HG22 sing N N 376 
VAL CG2 HG23 sing N N 377 
VAL OXT HXT  sing N N 378 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'German Research Foundation (DFG)'                        Germany 458246365 1 
'German Research Foundation (DFG)'                        Germany 451079909 2 
'German Federal Ministry for Economic Affairs and Energy' Germany 01KI2114  3 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   1IC6 
_pdbx_initial_refinement_model.details          ? 
# 
_pdbx_serial_crystallography_sample_delivery.diffrn_id     1 
_pdbx_serial_crystallography_sample_delivery.description   ? 
_pdbx_serial_crystallography_sample_delivery.method        'fixed target' 
# 
_pdbx_serial_crystallography_sample_delivery_fixed_target.diffrn_id                       1 
_pdbx_serial_crystallography_sample_delivery_fixed_target.description                     ? 
_pdbx_serial_crystallography_sample_delivery_fixed_target.sample_holding                  'HARE-Chip , kapton 125um' 
_pdbx_serial_crystallography_sample_delivery_fixed_target.support_base                    ? 
_pdbx_serial_crystallography_sample_delivery_fixed_target.sample_unit_size                ? 
_pdbx_serial_crystallography_sample_delivery_fixed_target.crystals_per_unit               ? 
_pdbx_serial_crystallography_sample_delivery_fixed_target.sample_solvent                  ? 
_pdbx_serial_crystallography_sample_delivery_fixed_target.sample_dehydration_prevention   ? 
_pdbx_serial_crystallography_sample_delivery_fixed_target.motion_control                  ? 
_pdbx_serial_crystallography_sample_delivery_fixed_target.velocity_horizontal             ? 
_pdbx_serial_crystallography_sample_delivery_fixed_target.velocity_vertical               ? 
_pdbx_serial_crystallography_sample_delivery_fixed_target.details                         ? 
# 
_space_group.name_H-M_alt     'P 43 21 2' 
_space_group.name_Hall        'P 4nw 2abw' 
_space_group.IT_number        96 
_space_group.crystal_system   tetragonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    8RSG 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.014599 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.014599 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009195 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356  2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
CA ? ? 16.26893 3.65395 ? ? 3.58509  77.28589 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032  2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882  3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732  6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . ALA A 1 106 ? 23.85662 -22.60869 -17.73916 1.000 15.71088 ? 1   ALA A N   1 
ATOM   2    C  CA  . ALA A 1 106 ? 25.01700 -22.25964 -16.85885 1.000 15.05644 ? 1   ALA A CA  1 
ATOM   3    C  C   . ALA A 1 106 ? 25.10713 -23.27581 -15.74076 1.000 15.09154 ? 1   ALA A C   1 
ATOM   4    O  O   . ALA A 1 106 ? 24.13063 -23.95069 -15.42855 1.000 14.57519 ? 1   ALA A O   1 
ATOM   5    C  CB  . ALA A 1 106 ? 24.86799 -20.86064 -16.27154 1.000 15.20990 ? 1   ALA A CB  1 
ATOM   6    N  N   . ALA A 1 107 ? 26.30122 -23.44986 -15.16283 1.000 14.95859 ? 2   ALA A N   1 
ATOM   7    C  CA  . ALA A 1 107 ? 26.44275 -24.42702 -14.10055 1.000 16.20067 ? 2   ALA A CA  1 
ATOM   8    C  C   . ALA A 1 107 ? 27.42956 -23.84111 -13.10257 1.000 23.21251 ? 2   ALA A C   1 
ATOM   9    O  O   . ALA A 1 107 ? 28.50024 -23.36249 -13.48775 1.000 20.79191 ? 2   ALA A O   1 
ATOM   10   C  CB  . ALA A 1 107 ? 26.93063 -25.79885 -14.58485 1.000 17.02623 ? 2   ALA A CB  1 
ATOM   11   N  N   . GLN A 1 108 ? 27.06549 -23.87456 -11.83233 1.000 12.27040 ? 3   GLN A N   1 
ATOM   12   C  CA  . GLN A 1 108 ? 27.96933 -23.47541 -10.76733 1.000 10.84996 ? 3   GLN A CA  1 
ATOM   13   C  C   . GLN A 1 108 ? 28.45938 -24.74184 -10.07322 1.000 11.31826 ? 3   GLN A C   1 
ATOM   14   O  O   . GLN A 1 108 ? 27.66305 -25.46421 -9.44921  1.000 10.55183 ? 3   GLN A O   1 
ATOM   15   C  CB  . GLN A 1 108 ? 27.21308 -22.56086 -9.77227  1.000 8.81496  ? 3   GLN A CB  1 
ATOM   16   C  CG  . GLN A 1 108 ? 28.07090 -22.20519 -8.60550  1.000 9.61160  ? 3   GLN A CG  1 
ATOM   17   C  CD  . GLN A 1 108 ? 27.28243 -21.46952 -7.53827  1.000 12.78602 ? 3   GLN A CD  1 
ATOM   18   O  OE1 . GLN A 1 108 ? 26.10944 -21.08300 -7.77068  1.000 12.60269 ? 3   GLN A OE1 1 
ATOM   19   N  NE2 . GLN A 1 108 ? 27.90621 -21.27008 -6.36365  1.000 10.58688 ? 3   GLN A NE2 1 
ATOM   20   N  N   . THR A 1 109 ? 29.77617 -25.04300 -10.17504 1.000 11.18014 ? 4   THR A N   1 
ATOM   21   C  CA  . THR A 1 109 ? 30.25891 -26.24421 -9.51181  1.000 12.91673 ? 4   THR A CA  1 
ATOM   22   C  C   . THR A 1 109 ? 30.52719 -25.97126 -8.02142  1.000 9.49382  ? 4   THR A C   1 
ATOM   23   O  O   . THR A 1 109 ? 30.76159 -24.83208 -7.60640  1.000 13.58805 ? 4   THR A O   1 
ATOM   24   C  CB  . THR A 1 109 ? 31.52682 -26.78390 -10.20603 1.000 19.69164 ? 4   THR A CB  1 
ATOM   25   O  OG1 . THR A 1 109 ? 32.48639 -25.74574 -10.22897 1.000 23.09211 ? 4   THR A OG1 1 
ATOM   26   C  CG2 . THR A 1 109 ? 31.23867 -27.19312 -11.63713 1.000 20.55961 ? 4   THR A CG2 1 
ATOM   27   N  N   . ASN A 1 110 ? 30.49456 -27.05155 -7.23238  1.000 14.10752 ? 5   ASN A N   1 
ATOM   28   C  CA  . ASN A 1 110 ? 30.70041 -26.99963 -5.78285  1.000 15.98338 ? 5   ASN A CA  1 
ATOM   29   C  C   . ASN A 1 110 ? 29.80341 -25.93875 -5.15523  1.000 14.77234 ? 5   ASN A C   1 
ATOM   30   O  O   . ASN A 1 110 ? 30.21268 -25.09499 -4.35895  1.000 15.73200 ? 5   ASN A O   1 
ATOM   31   C  CB  . ASN A 1 110 ? 32.16989 -26.77567 -5.40825  1.000 19.76249 ? 5   ASN A CB  1 
ATOM   32   C  CG  . ASN A 1 110 ? 33.05895 -27.82631 -6.03837  1.000 37.13366 ? 5   ASN A CG  1 
ATOM   33   O  OD1 . ASN A 1 110 ? 33.01123 -28.99238 -5.64754  1.000 39.68725 ? 5   ASN A OD1 1 
ATOM   34   N  ND2 . ASN A 1 110 ? 33.89461 -27.41877 -6.98425  1.000 44.29028 ? 5   ASN A ND2 1 
ATOM   35   N  N   . ALA A 1 111 ? 28.53356 -25.98743 -5.56139  1.000 12.18949 ? 6   ALA A N   1 
ATOM   36   C  CA  . ALA A 1 111 ? 27.58787 -25.01598 -5.04194  1.000 10.13848 ? 6   ALA A CA  1 
ATOM   37   C  C   . ALA A 1 111 ? 27.14674 -25.41641 -3.63074  1.000 9.86547  ? 6   ALA A C   1 
ATOM   38   O  O   . ALA A 1 111 ? 27.19797 -26.58773 -3.26660  1.000 13.34471 ? 6   ALA A O   1 
ATOM   39   C  CB  . ALA A 1 111 ? 26.37245 -24.97405 -5.97447  1.000 11.60211 ? 6   ALA A CB  1 
ATOM   40   N  N   . PRO A 1 112 ? 26.61168 -24.46822 -2.84920  1.000 8.67163  ? 7   PRO A N   1 
ATOM   41   C  CA  . PRO A 1 112 ? 25.91941 -24.87052 -1.61012  1.000 9.64614  ? 7   PRO A CA  1 
ATOM   42   C  C   . PRO A 1 112 ? 24.82431 -25.88635 -1.92160  1.000 10.33733 ? 7   PRO A C   1 
ATOM   43   O  O   . PRO A 1 112 ? 24.18814 -25.85487 -2.98160  1.000 11.91110 ? 7   PRO A O   1 
ATOM   44   C  CB  . PRO A 1 112 ? 25.30132 -23.57452 -1.08417  1.000 11.39082 ? 7   PRO A CB  1 
ATOM   45   C  CG  . PRO A 1 112 ? 26.00767 -22.44859 -1.80865  1.000 12.47726 ? 7   PRO A CG  1 
ATOM   46   C  CD  . PRO A 1 112 ? 26.58354 -23.02140 -3.09577  1.000 9.93133  ? 7   PRO A CD  1 
ATOM   47   N  N   . TRP A 1 113 ? 24.61720 -26.81234 -0.99379  1.000 7.79407  ? 8   TRP A N   1 
ATOM   48   C  CA  . TRP A 1 113 ? 23.77190 -27.96452 -1.32973  1.000 6.54134  ? 8   TRP A CA  1 
ATOM   49   C  C   . TRP A 1 113 ? 22.36249 -27.56587 -1.70227  1.000 6.92895  ? 8   TRP A C   1 
ATOM   50   O  O   . TRP A 1 113 ? 21.74610 -28.27889 -2.49700  1.000 8.42079  ? 8   TRP A O   1 
ATOM   51   C  CB  . TRP A 1 113 ? 23.73814 -28.94765 -0.14546  1.000 8.50404  ? 8   TRP A CB  1 
ATOM   52   C  CG  . TRP A 1 113 ? 22.82665 -28.56736 1.02136   1.000 8.33814  ? 8   TRP A CG  1 
ATOM   53   C  CD1 . TRP A 1 113 ? 23.19499 -27.93777 2.22339   1.000 9.12781  ? 8   TRP A CD1 1 
ATOM   54   C  CD2 . TRP A 1 113 ? 21.43271 -28.83909 1.13177   1.000 7.69272  ? 8   TRP A CD2 1 
ATOM   55   N  NE1 . TRP A 1 113 ? 22.08427 -27.79317 3.04116   1.000 8.11512  ? 8   TRP A NE1 1 
ATOM   56   C  CE2 . TRP A 1 113 ? 20.99224 -28.32992 2.38885   1.000 8.98930  ? 8   TRP A CE2 1 
ATOM   57   C  CE3 . TRP A 1 113 ? 20.49322 -29.45781 0.28309   1.000 8.07546  ? 8   TRP A CE3 1 
ATOM   58   C  CZ2 . TRP A 1 113 ? 19.64280 -28.41519 2.80161   1.000 7.99108  ? 8   TRP A CZ2 1 
ATOM   59   C  CZ3 . TRP A 1 113 ? 19.16902 -29.55164 0.69683   1.000 9.03427  ? 8   TRP A CZ3 1 
ATOM   60   C  CH2 . TRP A 1 113 ? 18.74494 -29.02153 1.94041   1.000 8.01362  ? 8   TRP A CH2 1 
ATOM   61   N  N   . GLY A 1 114 ? 21.83325 -26.49562 -1.09618  1.000 8.27118  ? 9   GLY A N   1 
ATOM   62   C  CA  . GLY A 1 114 ? 20.44686 -26.11692 -1.38116  1.000 7.00021  ? 9   GLY A CA  1 
ATOM   63   C  C   . GLY A 1 114 ? 20.25061 -25.64139 -2.80957  1.000 7.72288  ? 9   GLY A C   1 
ATOM   64   O  O   . GLY A 1 114 ? 19.19928 -25.90806 -3.42440  1.000 8.69462  ? 9   GLY A O   1 
ATOM   65   N  N   . LEU A 1 115 ? 21.24296 -24.91059 -3.35590  1.000 7.67295  ? 10  LEU A N   1 
ATOM   66   C  CA  . LEU A 1 115 ? 21.14540 -24.52090 -4.76748  1.000 6.80604  ? 10  LEU A CA  1 
ATOM   67   C  C   . LEU A 1 115 ? 21.22367 -25.75498 -5.67437  1.000 9.42668  ? 10  LEU A C   1 
ATOM   68   O  O   . LEU A 1 115 ? 20.46153 -25.88071 -6.64968  1.000 10.89931 ? 10  LEU A O   1 
ATOM   69   C  CB  . LEU A 1 115 ? 22.25917 -23.56038 -5.14693  1.000 9.47615  ? 10  LEU A CB  1 
ATOM   70   C  CG  . LEU A 1 115 ? 22.34692 -22.26388 -4.34299  1.000 11.42198 ? 10  LEU A CG  1 
ATOM   71   C  CD1 . LEU A 1 115 ? 23.40938 -21.32975 -5.02219  1.000 9.25459  ? 10  LEU A CD1 1 
ATOM   72   C  CD2 . LEU A 1 115 ? 20.98578 -21.53280 -4.36897  1.000 11.94922 ? 10  LEU A CD2 1 
ATOM   73   N  N   . ALA A 1 116 ? 22.14334 -26.68985 -5.37928  1.000 8.77054  ? 11  ALA A N   1 
ATOM   74   C  CA  . ALA A 1 116 ? 22.17250 -27.91229 -6.16686  1.000 8.37428  ? 11  ALA A CA  1 
ATOM   75   C  C   . ALA A 1 116 ? 20.84392 -28.65752 -6.09330  1.000 9.72398  ? 11  ALA A C   1 
ATOM   76   O  O   . ALA A 1 116 ? 20.36563 -29.19842 -7.10230  1.000 11.07209 ? 11  ALA A O   1 
ATOM   77   C  CB  . ALA A 1 116 ? 23.32755 -28.79118 -5.68463  1.000 10.13373 ? 11  ALA A CB  1 
ATOM   78   N  N   . ARG A 1 117 ? 20.22145 -28.68610 -4.91363  1.000 8.12903  ? 12  ARG A N   1 
ATOM   79   C  CA  . ARG A 1 117 ? 19.02271 -29.49576 -4.71891  1.000 7.88104  ? 12  ARG A CA  1 
ATOM   80   C  C   . ARG A 1 117 ? 17.88236 -28.96854 -5.56085  1.000 11.07715 ? 12  ARG A C   1 
ATOM   81   O  O   . ARG A 1 117 ? 17.07282 -29.76604 -6.04923  1.000 9.30744  ? 12  ARG A O   1 
ATOM   82   C  CB  . ARG A 1 117 ? 18.58571 -29.49851 -3.22632  1.000 9.35660  ? 12  ARG A CB  1 
ATOM   83   C  CG  . ARG A 1 117 ? 17.46776 -30.49575 -2.90832  1.000 9.83355  ? 12  ARG A CG  1 
ATOM   84   C  CD  . ARG A 1 117 ? 17.95092 -31.95158 -3.09091  1.000 12.19863 ? 12  ARG A CD  1 
ATOM   85   N  NE  . ARG A 1 117 ? 16.84529 -32.91689 -3.08080  1.000 8.74888  ? 12  ARG A NE  1 
ATOM   86   C  CZ  . ARG A 1 117 ? 16.17576 -33.28971 -4.17374  1.000 10.28129 ? 12  ARG A CZ  1 
ATOM   87   N  NH1 . ARG A 1 117 ? 16.36061 -32.68476 -5.33300  1.000 10.17545 ? 12  ARG A NH1 1 
ATOM   88   N  NH2 . ARG A 1 117 ? 15.30346 -34.29532 -4.09828  1.000 12.30396 ? 12  ARG A NH2 1 
ATOM   89   N  N   . ILE A 1 118 ? 17.74428 -27.63831 -5.65943  1.000 8.20855  ? 13  ILE A N   1 
ATOM   90   C  CA  . ILE A 1 118 ? 16.63215 -27.07488 -6.42396  1.000 7.28674  ? 13  ILE A CA  1 
ATOM   91   C  C   . ILE A 1 118 ? 16.81110 -27.22675 -7.91977  1.000 10.01456 ? 13  ILE A C   1 
ATOM   92   O  O   . ILE A 1 118 ? 15.86371 -26.93056 -8.65575  1.000 10.84743 ? 13  ILE A O   1 
ATOM   93   C  CB  . ILE A 1 118 ? 16.30439 -25.61227 -6.10746  1.000 11.99366 ? 13  ILE A CB  1 
ATOM   94   C  CG1 . ILE A 1 118 ? 17.40724 -24.66267 -6.52687  1.000 16.21926 ? 13  ILE A CG1 1 
ATOM   95   C  CG2 . ILE A 1 118 ? 15.83502 -25.46190 -4.60286  1.000 15.67021 ? 13  ILE A CG2 1 
ATOM   96   C  CD1 . ILE A 1 118 ? 16.97102 -23.19746 -6.34289  1.000 22.11250 ? 13  ILE A CD1 1 
ATOM   97   N  N   . SER A 1 119 ? 17.98272 -27.70163 -8.41192  1.000 7.85320  ? 14  SER A N   1 
ATOM   98   C  CA  . SER A 1 119 ? 18.14610 -27.94826 -9.85588  1.000 10.57371 ? 14  SER A CA  1 
ATOM   99   C  C   . SER A 1 119 ? 18.35351 -29.43341 -10.17265 1.000 13.36120 ? 14  SER A C   1 
ATOM   100  O  O   . SER A 1 119 ? 18.81080 -29.79386 -11.27963 1.000 15.86377 ? 14  SER A O   1 
ATOM   101  C  CB  . SER A 1 119 ? 19.28034 -27.09685 -10.43084 1.000 10.95354 ? 14  SER A CB  1 
ATOM   102  O  OG  . SER A 1 119 ? 20.56517 -27.47797 -9.89669  1.000 12.59792 ? 14  SER A OG  1 
ATOM   103  N  N   . SER A 1 120 ? 17.92436 -30.31260 -9.27852  1.000 8.97803  ? 15  SER A N   1 
ATOM   104  C  CA  . SER A 1 120 ? 18.11849 -31.75360 -9.41183  1.000 9.00420  ? 15  SER A CA  1 
ATOM   105  C  C   . SER A 1 120 ? 16.85573 -32.52874 -9.06309  1.000 12.64403 ? 15  SER A C   1 
ATOM   106  O  O   . SER A 1 120 ? 16.06145 -32.10611 -8.21740  1.000 11.40143 ? 15  SER A O   1 
ATOM   107  C  CB  . SER A 1 120 ? 19.24928 -32.22143 -8.47245  1.000 12.81125 ? 15  SER A CB  1 
ATOM   108  O  OG  . SER A 1 120 ? 19.51365 -33.63250 -8.69291  1.000 16.90704 ? 15  SER A OG  1 
ATOM   109  N  N   . THR A 1 121 ? 16.70054 -33.70768 -9.66952  1.000 14.77295 ? 16  THR A N   1 
ATOM   110  C  CA  . THR A 1 121 ? 15.63139 -34.57096 -9.20494  1.000 12.57517 ? 16  THR A CA  1 
ATOM   111  C  C   . THR A 1 121 ? 16.09370 -35.54881 -8.13831  1.000 17.67679 ? 16  THR A C   1 
ATOM   112  O  O   . THR A 1 121 ? 15.30911 -36.40738 -7.71913  1.000 25.85850 ? 16  THR A O   1 
ATOM   113  C  CB  . THR A 1 121 ? 15.01326 -35.35372 -10.35653 1.000 16.35925 ? 16  THR A CB  1 
ATOM   114  O  OG1 . THR A 1 121 ? 16.06537 -36.12568 -10.95886 1.000 19.08717 ? 16  THR A OG1 1 
ATOM   115  C  CG2 . THR A 1 121 ? 14.49172 -34.38917 -11.36752 1.000 18.17669 ? 16  THR A CG2 1 
ATOM   116  N  N   . SER A 1 122 ? 17.33756 -35.48376 -7.70508  1.000 17.31596 ? 17  SER A N   1 
ATOM   117  C  CA  . SER A 1 122 ? 17.78956 -36.37852 -6.62864  1.000 16.00856 ? 17  SER A CA  1 
ATOM   118  C  C   . SER A 1 122 ? 18.68858 -35.62581 -5.65325  1.000 13.72361 ? 17  SER A C   1 
ATOM   119  O  O   . SER A 1 122 ? 19.36912 -34.67237 -6.04384  1.000 14.63343 ? 17  SER A O   1 
ATOM   120  C  CB  . SER A 1 122 ? 18.55085 -37.58758 -7.19209  1.000 16.73925 ? 17  SER A CB  1 
ATOM   121  O  OG  . SER A 1 122 ? 19.62158 -37.12087 -7.97747  1.000 29.59350 ? 17  SER A OG  1 
ATOM   122  N  N   . PRO A 1 123 ? 18.71477 -36.02988 -4.38606  1.000 14.30423 ? 18  PRO A N   1 
ATOM   123  C  CA  . PRO A 1 123 ? 19.63064 -35.39885 -3.43928  1.000 13.06200 ? 18  PRO A CA  1 
ATOM   124  C  C   . PRO A 1 123 ? 21.05201 -35.86724 -3.68137  1.000 13.81415 ? 18  PRO A C   1 
ATOM   125  O  O   . PRO A 1 123 ? 21.29951 -36.85278 -4.39467  1.000 18.44010 ? 18  PRO A O   1 
ATOM   126  C  CB  . PRO A 1 123 ? 19.11734 -35.87235 -2.07466  1.000 15.06347 ? 18  PRO A CB  1 
ATOM   127  C  CG  . PRO A 1 123 ? 18.47713 -37.24700 -2.37423  1.000 18.52285 ? 18  PRO A CG  1 
ATOM   128  C  CD  . PRO A 1 123 ? 17.96304 -37.14583 -3.78643  1.000 19.41270 ? 18  PRO A CD  1 
ATOM   129  N  N   . GLY A 1 124 ? 21.98986 -35.12892 -3.09834  1.000 15.23861 ? 19  GLY A N   1 
ATOM   130  C  CA  . GLY A 1 124 ? 23.38154 -35.54075 -3.08550  1.000 15.60136 ? 19  GLY A CA  1 
ATOM   131  C  C   . GLY A 1 124 ? 24.24000 -34.99084 -4.19741  1.000 19.83482 ? 19  GLY A C   1 
ATOM   132  O  O   . GLY A 1 124 ? 25.39106 -35.39890 -4.31440  1.000 20.91628 ? 19  GLY A O   1 
ATOM   133  N  N   . THR A 1 125 ? 23.71624 -34.12379 -5.04963  1.000 15.25051 ? 20  THR A N   1 
ATOM   134  C  CA  . THR A 1 125 ? 24.51773 -33.52366 -6.11962  1.000 13.95394 ? 20  THR A CA  1 
ATOM   135  C  C   . THR A 1 125 ? 25.17370 -32.22228 -5.63776  1.000 13.88194 ? 20  THR A C   1 
ATOM   136  O  O   . THR A 1 125 ? 24.81513 -31.65157 -4.60888  1.000 16.33670 ? 20  THR A O   1 
ATOM   137  C  CB  . THR A 1 125 ? 23.67468 -33.24978 -7.37401  1.000 20.50621 ? 20  THR A CB  1 
ATOM   138  O  OG1 . THR A 1 125 ? 22.75163 -32.18125 -7.10606  1.000 18.26011 ? 20  THR A OG1 1 
ATOM   139  C  CG2 . THR A 1 125 ? 22.87163 -34.45838 -7.82491  1.000 17.77990 ? 20  THR A CG2 1 
ATOM   140  N  N   . SER A 1 126 ? 26.15117 -31.73077 -6.39749  1.000 16.24424 ? 21  SER A N   1 
ATOM   141  C  CA  . SER A 1 126 ? 26.86605 -30.54361 -5.94956  1.000 16.57684 ? 21  SER A CA  1 
ATOM   142  C  C   . SER A 1 126 ? 26.93768 -29.44042 -7.00572  1.000 12.51715 ? 21  SER A C   1 
ATOM   143  O  O   . SER A 1 126 ? 27.64591 -28.45584 -6.79320  1.000 16.16277 ? 21  SER A O   1 
ATOM   144  C  CB  . SER A 1 126 ? 28.28638 -30.91090 -5.48989  1.000 20.54174 ? 21  SER A CB  1 
ATOM   145  O  OG  . SER A 1 126 ? 28.92180 -31.44777 -6.60775  1.000 26.61348 ? 21  SER A OG  1 
ATOM   146  N  N   . THR A 1 127 ? 26.24800 -29.57313 -8.14706  1.000 11.60978 ? 22  THR A N   1 
ATOM   147  C  CA  . THR A 1 127 ? 26.27605 -28.54601 -9.17810  1.000 11.15755 ? 22  THR A CA  1 
ATOM   148  C  C   . THR A 1 127 ? 24.90394 -27.88843 -9.25052  1.000 11.01581 ? 22  THR A C   1 
ATOM   149  O  O   . THR A 1 127 ? 23.88840 -28.59636 -9.27895  1.000 13.75960 ? 22  THR A O   1 
ATOM   150  C  CB  . THR A 1 127 ? 26.62736 -29.13887 -10.53550 1.000 14.30374 ? 22  THR A CB  1 
ATOM   151  O  OG1 . THR A 1 127 ? 27.95843 -29.73912 -10.42980 1.000 19.17554 ? 22  THR A OG1 1 
ATOM   152  C  CG2 . THR A 1 127 ? 26.64885 -28.11823 -11.59249 1.000 13.97883 ? 22  THR A CG2 1 
ATOM   153  N  N   . TYR A 1 128 ? 24.89695 -26.55750 -9.29207  1.000 8.55174  ? 23  TYR A N   1 
ATOM   154  C  CA  . TYR A 1 128 ? 23.65437 -25.80574 -9.52838  1.000 8.19937  ? 23  TYR A CA  1 
ATOM   155  C  C   . TYR A 1 128 ? 23.54656 -25.45606 -11.01241 1.000 10.01491 ? 23  TYR A C   1 
ATOM   156  O  O   . TYR A 1 128 ? 24.36059 -24.69705 -11.53895 1.000 10.12257 ? 23  TYR A O   1 
ATOM   157  C  CB  . TYR A 1 128 ? 23.64598 -24.54613 -8.65336  1.000 7.20899  ? 23  TYR A CB  1 
ATOM   158  C  CG  . TYR A 1 128 ? 22.46690 -23.57322 -8.86534  1.000 7.54281  ? 23  TYR A CG  1 
ATOM   159  C  CD1 . TYR A 1 128 ? 21.18825 -24.06999 -9.12915  1.000 9.71371  ? 23  TYR A CD1 1 
ATOM   160  C  CD2 . TYR A 1 128 ? 22.66834 -22.19982 -8.79857  1.000 8.54516  ? 23  TYR A CD2 1 
ATOM   161  C  CE1 . TYR A 1 128 ? 20.13326 -23.15435 -9.28003  1.000 8.05539  ? 23  TYR A CE1 1 
ATOM   162  C  CE2 . TYR A 1 128 ? 21.60016 -21.28384 -8.93927  1.000 7.61491  ? 23  TYR A CE2 1 
ATOM   163  C  CZ  . TYR A 1 128 ? 20.34909 -21.81466 -9.19904  1.000 10.24640 ? 23  TYR A CZ  1 
ATOM   164  O  OH  . TYR A 1 128 ? 19.29967 -20.94081 -9.35827  1.000 10.57710 ? 23  TYR A OH  1 
ATOM   165  N  N   . TYR A 1 129 ? 22.52353 -25.99867 -11.69050 1.000 11.01246 ? 24  TYR A N   1 
ATOM   166  C  CA  . TYR A 1 129 ? 22.29650 -25.73610 -13.11228 1.000 12.74247 ? 24  TYR A CA  1 
ATOM   167  C  C   . TYR A 1 129 ? 21.18355 -24.71705 -13.23882 1.000 9.50334  ? 24  TYR A C   1 
ATOM   168  O  O   . TYR A 1 129 ? 20.13834 -24.90230 -12.60496 1.000 13.91645 ? 24  TYR A O   1 
ATOM   169  C  CB  . TYR A 1 129 ? 21.87847 -27.01713 -13.81577 1.000 12.99085 ? 24  TYR A CB  1 
ATOM   170  C  CG  . TYR A 1 129 ? 22.85205 -28.21730 -13.71317 1.000 12.82795 ? 24  TYR A CG  1 
ATOM   171  C  CD1 . TYR A 1 129 ? 23.92614 -28.37087 -14.59741 1.000 29.49270 ? 24  TYR A CD1 1 
ATOM   172  C  CD2 . TYR A 1 129 ? 22.61265 -29.21220 -12.75490 1.000 20.47879 ? 24  TYR A CD2 1 
ATOM   173  C  CE1 . TYR A 1 129 ? 24.76913 -29.48987 -14.48108 1.000 25.88226 ? 24  TYR A CE1 1 
ATOM   174  C  CE2 . TYR A 1 129 ? 23.44454 -30.32725 -12.64004 1.000 25.96427 ? 24  TYR A CE2 1 
ATOM   175  C  CZ  . TYR A 1 129 ? 24.50532 -30.45624 -13.51084 1.000 24.55963 ? 24  TYR A CZ  1 
ATOM   176  O  OH  . TYR A 1 129 ? 25.32374 -31.59150 -13.37778 1.000 31.90640 ? 24  TYR A OH  1 
ATOM   177  N  N   . TYR A 1 130 ? 21.40064 -23.67697 -14.04539 1.000 9.19905  ? 25  TYR A N   1 
ATOM   178  C  CA  . TYR A 1 130 ? 20.40843 -22.59786 -14.16474 1.000 11.50197 ? 25  TYR A CA  1 
ATOM   179  C  C   . TYR A 1 130 ? 20.57477 -21.84953 -15.48500 1.000 11.48563 ? 25  TYR A C   1 
ATOM   180  O  O   . TYR A 1 130 ? 21.65177 -21.84324 -16.08796 1.000 11.74524 ? 25  TYR A O   1 
ATOM   181  C  CB  . TYR A 1 130 ? 20.53893 -21.63056 -12.94310 1.000 9.05704  ? 25  TYR A CB  1 
ATOM   182  C  CG  . TYR A 1 130 ? 21.87772 -20.88292 -12.86525 1.000 11.49860 ? 25  TYR A CG  1 
ATOM   183  C  CD1 . TYR A 1 130 ? 22.99370 -21.52418 -12.32153 1.000 10.50680 ? 25  TYR A CD1 1 
ATOM   184  C  CD2 . TYR A 1 130 ? 22.03116 -19.57388 -13.38464 1.000 8.96026  ? 25  TYR A CD2 1 
ATOM   185  C  CE1 . TYR A 1 130 ? 24.21673 -20.89568 -12.32102 1.000 10.69900 ? 25  TYR A CE1 1 
ATOM   186  C  CE2 . TYR A 1 130 ? 23.28068 -18.89279 -13.36656 1.000 10.66871 ? 25  TYR A CE2 1 
ATOM   187  C  CZ  . TYR A 1 130 ? 24.35066 -19.57171 -12.78938 1.000 14.38624 ? 25  TYR A CZ  1 
ATOM   188  O  OH  . TYR A 1 130 ? 25.56829 -18.92687 -12.76659 1.000 18.85037 ? 25  TYR A OH  1 
ATOM   189  N  N   . ASP A 1 131 ? 19.48982 -21.24077 -15.95043 1.000 9.49937  ? 26  ASP A N   1 
ATOM   190  C  CA  . ASP A 1 131 ? 19.55858 -20.39815 -17.12812 1.000 11.53066 ? 26  ASP A CA  1 
ATOM   191  C  C   . ASP A 1 131 ? 20.30725 -19.10673 -16.83280 1.000 11.04279 ? 26  ASP A C   1 
ATOM   192  O  O   . ASP A 1 131 ? 20.07506 -18.44872 -15.80292 1.000 11.81981 ? 26  ASP A O   1 
ATOM   193  C  CB  . ASP A 1 131 ? 18.12910 -20.04731 -17.61158 1.000 10.75851 ? 26  ASP A CB  1 
ATOM   194  C  CG  . ASP A 1 131 ? 18.13731 -19.35425 -18.98321 1.000 13.12476 ? 26  ASP A CG  1 
ATOM   195  O  OD1 . ASP A 1 131 ? 18.10180 -20.10508 -19.99002 1.000 21.47475 ? 26  ASP A OD1 1 
ATOM   196  O  OD2 . ASP A 1 131 ? 18.16059 -18.10561 -19.05449 1.000 14.42395 ? 26  ASP A OD2 1 
ATOM   197  N  N   . GLU A 1 132 ? 21.19983 -18.72372 -17.78781 1.000 11.46460 ? 27  GLU A N   1 
ATOM   198  C  CA  . GLU A 1 132 ? 22.01588 -17.51184 -17.71838 1.000 12.74915 ? 27  GLU A CA  1 
ATOM   199  C  C   . GLU A 1 132 ? 21.23783 -16.22175 -17.42536 1.000 12.20629 ? 27  GLU A C   1 
ATOM   200  O  O   . GLU A 1 132 ? 21.83993 -15.26648 -16.93792 1.000 13.41224 ? 27  GLU A O   1 
ATOM   201  C  CB  . GLU A 1 132 ? 22.71879 -17.27762 -19.09057 1.000 20.70954 ? 27  GLU A CB  1 
ATOM   202  C  CG  . GLU A 1 132 ? 23.90206 -18.15923 -19.57564 1.000 43.46535 ? 27  GLU A CG  1 
ATOM   203  C  CD  . GLU A 1 132 ? 23.66277 -19.70410 -19.57093 1.000 48.44513 ? 27  GLU A CD  1 
ATOM   204  O  OE1 . GLU A 1 132 ? 22.53535 -20.20085 -19.81548 1.000 26.78803 ? 27  GLU A OE1 1 
ATOM   205  O  OE2 . GLU A 1 132 ? 24.65404 -20.44918 -19.45582 1.000 37.03587 ? 27  GLU A OE2 1 
ATOM   206  N  N   . SER A 1 133 ? 19.92416 -16.14532 -17.76221 1.000 12.33504 ? 28  SER A N   1 
ATOM   207  C  CA  . SER A 1 133 ? 19.17389 -14.90403 -17.52296 1.000 9.80598  ? 28  SER A CA  1 
ATOM   208  C  C   . SER A 1 133 ? 19.15318 -14.56521 -16.03579 1.000 10.95608 ? 28  SER A C   1 
ATOM   209  O  O   . SER A 1 133 ? 19.18531 -13.38567 -15.66084 1.000 12.45948 ? 28  SER A O   1 
ATOM   210  C  CB  . SER A 1 133 ? 17.74375 -15.04660 -18.05125 1.000 9.81052  ? 28  SER A CB  1 
ATOM   211  O  OG  . SER A 1 133 ? 17.10004 -16.19099 -17.52114 1.000 14.31583 ? 28  SER A OG  1 
ATOM   212  N  N   . ALA A 1 134 ? 19.10588 -15.61029 -15.19690 1.000 10.17683 ? 29  ALA A N   1 
ATOM   213  C  CA  . ALA A 1 134 ? 19.40700 -15.51868 -13.74393 1.000 6.90041  ? 29  ALA A CA  1 
ATOM   214  C  C   . ALA A 1 134 ? 18.57585 -14.45717 -13.02334 1.000 9.14248  ? 29  ALA A C   1 
ATOM   215  O  O   . ALA A 1 134 ? 19.04133 -13.77185 -12.13859 1.000 10.37019 ? 29  ALA A O   1 
ATOM   216  C  CB  . ALA A 1 134 ? 20.91567 -15.27246 -13.50325 1.000 12.15131 ? 29  ALA A CB  1 
ATOM   217  N  N   . GLY A 1 135 ? 17.30109 -14.29072 -13.39803 1.000 8.53416  ? 30  GLY A N   1 
ATOM   218  C  CA  . GLY A 1 135 ? 16.53361 -13.28020 -12.70637 1.000 8.16862  ? 30  GLY A CA  1 
ATOM   219  C  C   . GLY A 1 135 ? 16.73683 -11.83183 -13.10154 1.000 7.22986  ? 30  GLY A C   1 
ATOM   220  O  O   . GLY A 1 135 ? 16.13849 -10.94143 -12.45323 1.000 9.64501  ? 30  GLY A O   1 
ATOM   221  N  N   . GLN A 1 136 ? 17.48570 -11.55623 -14.17449 1.000 9.64731  ? 31  GLN A N   1 
ATOM   222  C  CA  . GLN A 1 136 ? 17.69828 -10.17668 -14.57626 1.000 8.20254  ? 31  GLN A CA  1 
ATOM   223  C  C   . GLN A 1 136 ? 16.36131 -9.53661  -14.94888 1.000 12.93420 ? 31  GLN A C   1 
ATOM   224  O  O   . GLN A 1 136 ? 15.56549 -10.12387 -15.67870 1.000 14.55904 ? 31  GLN A O   1 
ATOM   225  C  CB  . GLN A 1 136 ? 18.63267 -10.14984 -15.79299 1.000 12.81091 ? 31  GLN A CB  1 
ATOM   226  C  CG  . GLN A 1 136 ? 19.06973 -8.72124  -16.13081 1.000 20.97961 ? 31  GLN A CG  1 
ATOM   227  C  CD  . GLN A 1 136 ? 20.25277 -8.69062  -17.08374 1.000 49.91384 ? 31  GLN A CD  1 
ATOM   228  O  OE1 . GLN A 1 136 ? 20.89168 -9.71330  -17.32557 1.000 47.26208 ? 31  GLN A OE1 1 
ATOM   229  N  NE2 . GLN A 1 136 ? 20.54212 -7.51316  -17.63537 1.000 59.93738 ? 31  GLN A NE2 1 
ATOM   230  N  N   . GLY A 1 137 ? 16.15504 -8.30261  -14.49316 1.000 8.65185  ? 32  GLY A N   1 
ATOM   231  C  CA  . GLY A 1 137 ? 14.90747 -7.60772  -14.78841 1.000 11.54285 ? 32  GLY A CA  1 
ATOM   232  C  C   . GLY A 1 137 ? 13.80977 -7.79957  -13.76654 1.000 12.67298 ? 32  GLY A C   1 
ATOM   233  O  O   . GLY A 1 137 ? 12.79174 -7.10057  -13.85039 1.000 11.04341 ? 32  GLY A O   1 
ATOM   234  N  N   . SER A 1 138 ? 13.97351 -8.72766  -12.81507 1.000 9.95142  ? 33  SER A N   1 
ATOM   235  C  CA  . SER A 1 138 ? 13.07353 -8.85998  -11.66528 1.000 8.21465  ? 33  SER A CA  1 
ATOM   236  C  C   . SER A 1 138 ? 13.63010 -8.12057  -10.43834 1.000 6.87663  ? 33  SER A C   1 
ATOM   237  O  O   . SER A 1 138 ? 14.80943 -7.69968  -10.39235 1.000 9.19136  ? 33  SER A O   1 
ATOM   238  C  CB  . SER A 1 138 ? 12.84673 -10.32624 -11.31647 1.000 9.14746  ? 33  SER A CB  1 
ATOM   239  O  OG  . SER A 1 138 ? 14.02769 -10.88158 -10.78213 1.000 11.23128 ? 33  SER A OG  1 
ATOM   240  N  N   . CYS A 1 139 ? 12.74313 -7.92666  -9.45566  1.000 7.28948  ? 34  CYS A N   1 
ATOM   241  C  CA  . CYS A 1 139 ? 13.08411 -7.23430  -8.22042  1.000 8.36717  ? 34  CYS A CA  1 
ATOM   242  C  C   . CYS A 1 139 ? 12.60021 -8.06163  -7.04604  1.000 7.25054  ? 34  CYS A C   1 
ATOM   243  O  O   . CYS A 1 139 ? 11.45961 -8.51928  -7.05004  1.000 10.08917 ? 34  CYS A O   1 
ATOM   244  C  CB  . CYS A 1 139 ? 12.46461 -5.84563  -8.11387  1.000 9.84807  ? 34  CYS A CB  1 
ATOM   245  S  SG  . CYS A 1 139 ? 13.08231 -4.78600  -9.48443  1.000 10.57632 ? 34  CYS A SG  1 
ATOM   246  N  N   . VAL A 1 140 ? 13.43380 -8.16871  -5.99712  1.000 6.19276  ? 35  VAL A N   1 
ATOM   247  C  CA  . VAL A 1 140 ? 12.99618 -8.90353  -4.78126  1.000 6.33478  ? 35  VAL A CA  1 
ATOM   248  C  C   . VAL A 1 140 ? 13.18476 -7.98347  -3.59904  1.000 7.55775  ? 35  VAL A C   1 
ATOM   249  O  O   . VAL A 1 140 ? 14.31907 -7.57453  -3.30664  1.000 9.18990  ? 35  VAL A O   1 
ATOM   250  C  CB  . VAL A 1 140 ? 13.80286 -10.20584 -4.56558  1.000 6.10324  ? 35  VAL A CB  1 
ATOM   251  C  CG1 . VAL A 1 140 ? 13.27224 -10.93978 -3.32735  1.000 8.77093  ? 35  VAL A CG1 1 
ATOM   252  C  CG2 . VAL A 1 140 ? 13.66471 -11.12866 -5.82338  1.000 6.69375  ? 35  VAL A CG2 1 
ATOM   253  N  N   . TYR A 1 141 ? 12.10523 -7.75637  -2.84328  1.000 5.93959  ? 36  TYR A N   1 
ATOM   254  C  CA  . TYR A 1 141 ? 12.18203 -7.00319  -1.59352  1.000 4.96437  ? 36  TYR A CA  1 
ATOM   255  C  C   . TYR A 1 141 ? 12.42870 -7.98677  -0.46917  1.000 9.11017  ? 36  TYR A C   1 
ATOM   256  O  O   . TYR A 1 141 ? 11.71618 -8.96695  -0.36214  1.000 8.41923  ? 36  TYR A O   1 
ATOM   257  C  CB  . TYR A 1 141 ? 10.86932 -6.25690  -1.32792  1.000 6.03018  ? 36  TYR A CB  1 
ATOM   258  C  CG  . TYR A 1 141 ? 10.65365 -5.03527  -2.18463  1.000 7.33766  ? 36  TYR A CG  1 
ATOM   259  C  CD1 . TYR A 1 141 ? 10.13519 -5.16599  -3.49761  1.000 7.58400  ? 36  TYR A CD1 1 
ATOM   260  C  CD2 . TYR A 1 141 ? 10.91706 -3.76450  -1.67226  1.000 6.64734  ? 36  TYR A CD2 1 
ATOM   261  C  CE1 . TYR A 1 141 ? 9.89423  -4.03376  -4.28558  1.000 8.35104  ? 36  TYR A CE1 1 
ATOM   262  C  CE2 . TYR A 1 141 ? 10.64662 -2.61108  -2.44983  1.000 6.42270  ? 36  TYR A CE2 1 
ATOM   263  C  CZ  . TYR A 1 141 ? 10.16247 -2.78661  -3.75644  1.000 7.02974  ? 36  TYR A CZ  1 
ATOM   264  O  OH  . TYR A 1 141 ? 9.89634  -1.62692  -4.48465  1.000 9.85753  ? 36  TYR A OH  1 
ATOM   265  N  N   . VAL A 1 142 ? 13.44107 -7.73525  0.35709   1.000 5.07814  ? 37  VAL A N   1 
ATOM   266  C  CA  . VAL A 1 142 ? 13.73257 -8.61470  1.49547   1.000 6.41150  ? 37  VAL A CA  1 
ATOM   267  C  C   . VAL A 1 142 ? 13.32911 -7.82231  2.72283   1.000 7.05279  ? 37  VAL A C   1 
ATOM   268  O  O   . VAL A 1 142 ? 13.92838 -6.78810  2.99648   1.000 9.27727  ? 37  VAL A O   1 
ATOM   269  C  CB  . VAL A 1 142 ? 15.22434 -8.99254  1.54344   1.000 7.35146  ? 37  VAL A CB  1 
ATOM   270  C  CG1 . VAL A 1 142 ? 15.51922 -9.95170  2.72631   1.000 10.52672 ? 37  VAL A CG1 1 
ATOM   271  C  CG2 . VAL A 1 142 ? 15.63990 -9.74226  0.29351   1.000 11.44056 ? 37  VAL A CG2 1 
ATOM   272  N  N   . ILE A 1 143 ? 12.26705 -8.25421  3.42074   1.000 5.39444  ? 38  ILE A N   1 
ATOM   273  C  CA  . ILE A 1 143 ? 11.66977 -7.49139  4.50368   1.000 6.09600  ? 38  ILE A CA  1 
ATOM   274  C  C   . ILE A 1 143 ? 12.14483 -8.15115  5.79684   1.000 6.54567  ? 38  ILE A C   1 
ATOM   275  O  O   . ILE A 1 143 ? 11.71773 -9.26658  6.10417   1.000 8.08197  ? 38  ILE A O   1 
ATOM   276  C  CB  . ILE A 1 143 ? 10.13785 -7.50215  4.35461   1.000 6.91715  ? 38  ILE A CB  1 
ATOM   277  C  CG1 . ILE A 1 143 ? 9.78377  -6.95729  2.96128   1.000 12.31994 ? 38  ILE A CG1 1 
ATOM   278  C  CG2 . ILE A 1 143 ? 9.43408  -6.73343  5.51156   1.000 9.33436  ? 38  ILE A CG2 1 
ATOM   279  C  CD1 . ILE A 1 143 ? 8.22687  -7.12912  2.59636   1.000 13.56021 ? 38  ILE A CD1 1 
ATOM   280  N  N   . ASP A 1 144 ? 13.09873 -7.50311  6.50417   1.000 6.44209  ? 39  ASP A N   1 
ATOM   281  C  CA  . ASP A 1 144 ? 13.91052 -8.27942  7.46842   1.000 4.95990  ? 39  ASP A CA  1 
ATOM   282  C  C   . ASP A 1 144 ? 14.73419 -7.30340  8.32706   1.000 7.21547  ? 39  ASP A C   1 
ATOM   283  O  O   . ASP A 1 144 ? 14.23410 -6.22686  8.63151   1.000 7.82979  ? 39  ASP A O   1 
ATOM   284  C  CB  . ASP A 1 144 ? 14.79240 -9.30521  6.70634   1.000 5.81473  ? 39  ASP A CB  1 
ATOM   285  C  CG  . ASP A 1 144 ? 15.12310 -10.51286 7.52600   1.000 9.75183  ? 39  ASP A CG  1 
ATOM   286  O  OD1 . ASP A 1 144 ? 15.88673 -10.37668 8.51065   1.000 8.95738  ? 39  ASP A OD1 1 
ATOM   287  O  OD2 . ASP A 1 144 ? 14.65790 -11.62466 7.15417   1.000 12.55828 ? 39  ASP A OD2 1 
ATOM   288  N  N   . THR A 1 145 ? 15.92498 -7.68795  8.78022   1.000 7.27394  ? 40  THR A N   1 
ATOM   289  C  CA  . THR A 1 145 ? 16.76181 -6.79027  9.61867   1.000 4.53346  ? 40  THR A CA  1 
ATOM   290  C  C   . THR A 1 145 ? 17.58321 -5.80173  8.81007   1.000 7.43385  ? 40  THR A C   1 
ATOM   291  O  O   . THR A 1 145 ? 18.41681 -5.08842  9.40480   1.000 8.24357  ? 40  THR A O   1 
ATOM   292  C  CB  . THR A 1 145 ? 17.73207 -7.59695  10.50444  1.000 5.62574  ? 40  THR A CB  1 
ATOM   293  O  OG1 . THR A 1 145 ? 18.63364 -8.33664  9.62490   1.000 8.04464  ? 40  THR A OG1 1 
ATOM   294  C  CG2 . THR A 1 145 ? 16.93965 -8.56855  11.41531  1.000 9.71958  ? 40  THR A CG2 1 
ATOM   295  N  N   . GLY A 1 146 ? 17.42687 -5.78532  7.48222   1.000 8.17205  ? 41  GLY A N   1 
ATOM   296  C  CA  . GLY A 1 146 ? 18.27026 -4.97136  6.61593   1.000 6.75753  ? 41  GLY A CA  1 
ATOM   297  C  C   . GLY A 1 146 ? 19.16363 -5.84071  5.74815   1.000 6.85078  ? 41  GLY A C   1 
ATOM   298  O  O   . GLY A 1 146 ? 19.14687 -7.07475  5.81859   1.000 10.70785 ? 41  GLY A O   1 
ATOM   299  N  N   . ILE A 1 147 ? 19.96097 -5.18876  4.91471   1.000 7.12150  ? 42  ILE A N   1 
ATOM   300  C  CA  . ILE A 1 147 ? 20.89769 -5.86067  4.01029   1.000 6.66940  ? 42  ILE A CA  1 
ATOM   301  C  C   . ILE A 1 147 ? 22.19281 -5.06380  4.05737   1.000 8.04888  ? 42  ILE A C   1 
ATOM   302  O  O   . ILE A 1 147 ? 22.16927 -3.82893  3.87610   1.000 10.48100 ? 42  ILE A O   1 
ATOM   303  C  CB  . ILE A 1 147 ? 20.43681 -5.93530  2.53177   1.000 10.73022 ? 42  ILE A CB  1 
ATOM   304  C  CG1 . ILE A 1 147 ? 19.05704 -6.57418  2.42124   1.000 10.38250 ? 42  ILE A CG1 1 
ATOM   305  C  CG2 . ILE A 1 147 ? 21.48688 -6.74482  1.67322   1.000 11.48590 ? 42  ILE A CG2 1 
ATOM   306  C  CD1 . ILE A 1 147 ? 18.51099 -6.45175  0.92801   1.000 9.33714  ? 42  ILE A CD1 1 
ATOM   307  N  N   . GLU A 1 148 ? 23.31319 -5.75469  4.26150   1.000 6.79470  ? 43  GLU A N   1 
ATOM   308  C  CA  . GLU A 1 148 ? 24.62926 -5.11090  4.09325   1.000 7.62307  ? 43  GLU A CA  1 
ATOM   309  C  C   . GLU A 1 148 ? 24.91666 -4.97625  2.58911   1.000 8.74217  ? 43  GLU A C   1 
ATOM   310  O  O   . GLU A 1 148 ? 25.56008 -5.83347  1.94361   1.000 10.92803 ? 43  GLU A O   1 
ATOM   311  C  CB  . GLU A 1 148 ? 25.70947 -5.91953  4.80106   1.000 9.91412  ? 43  GLU A CB  1 
ATOM   312  C  CG  . GLU A 1 148 ? 27.10973 -5.21081  4.79756   1.000 9.51517  ? 43  GLU A CG  1 
ATOM   313  C  CD  . GLU A 1 148 ? 28.10770 -5.98521  5.64463   1.000 8.42851  ? 43  GLU A CD  1 
ATOM   314  O  OE1 . GLU A 1 148 ? 28.03391 -5.76030  6.87402   1.000 12.02310 ? 43  GLU A OE1 1 
ATOM   315  O  OE2 . GLU A 1 148 ? 28.90237 -6.74810  5.01468   1.000 13.92912 ? 43  GLU A OE2 1 
ATOM   316  N  N   . ALA A 1 149 ? 24.44780 -3.83404  2.03383   1.000 9.46389  ? 44  ALA A N   1 
ATOM   317  C  CA  . ALA A 1 149 ? 24.47343 -3.68158  0.56644   1.000 11.77800 ? 44  ALA A CA  1 
ATOM   318  C  C   . ALA A 1 149 ? 25.87643 -3.61397  0.00569   1.000 12.04235 ? 44  ALA A C   1 
ATOM   319  O  O   . ALA A 1 149 ? 26.07529 -3.91339  -1.18199  1.000 17.23062 ? 44  ALA A O   1 
ATOM   320  C  CB  . ALA A 1 149 ? 23.69460 -2.41918  0.17852   1.000 16.63985 ? 44  ALA A CB  1 
ATOM   321  N  N   . SER A 1 150 ? 26.84650 -3.21828  0.82192   1.000 11.12888 ? 45  SER A N   1 
ATOM   322  C  CA  . SER A 1 150 ? 28.22546 -3.13151  0.35429   1.000 11.41534 ? 45  SER A CA  1 
ATOM   323  C  C   . SER A 1 150 ? 28.93026 -4.47336  0.25456   1.000 13.16864 ? 45  SER A C   1 
ATOM   324  O  O   . SER A 1 150 ? 30.08916 -4.50029  -0.17219  1.000 12.62624 ? 45  SER A O   1 
ATOM   325  C  CB  . SER A 1 150 ? 28.99773 -2.19284  1.27614   1.000 15.72334 ? 45  SER A CB  1 
ATOM   326  O  OG  . SER A 1 150 ? 29.12330 -2.78790  2.54988   1.000 20.30223 ? 45  SER A OG  1 
ATOM   327  N  N   . HIS A 1 151 ? 28.29471 -5.59971  0.68393   1.000 9.66927  ? 46  HIS A N   1 
ATOM   328  C  CA  . HIS A 1 151 ? 28.97384 -6.86766  0.60835   1.000 9.19163  ? 46  HIS A CA  1 
ATOM   329  C  C   . HIS A 1 151 ? 29.35824 -7.15434  -0.84825  1.000 9.48473  ? 46  HIS A C   1 
ATOM   330  O  O   . HIS A 1 151 ? 28.50560 -7.07197  -1.74661  1.000 10.13913 ? 46  HIS A O   1 
ATOM   331  C  CB  . HIS A 1 151 ? 28.02320 -7.96112  1.13101   1.000 8.12283  ? 46  HIS A CB  1 
ATOM   332  C  CG  . HIS A 1 151 ? 28.71893 -9.25217  1.51178   1.000 9.52384  ? 46  HIS A CG  1 
ATOM   333  N  ND1 . HIS A 1 151 ? 29.46865 -10.00554 0.62555   1.000 9.50005  ? 46  HIS A ND1 1 
ATOM   334  C  CD2 . HIS A 1 151 ? 28.76114 -9.91596  2.70056   1.000 11.31186 ? 46  HIS A CD2 1 
ATOM   335  C  CE1 . HIS A 1 151 ? 29.92889 -11.07666 1.23680   1.000 11.08978 ? 46  HIS A CE1 1 
ATOM   336  N  NE2 . HIS A 1 151 ? 29.52541 -11.03557 2.50010   1.000 10.04413 ? 46  HIS A NE2 1 
ATOM   337  N  N   . PRO A 1 152 ? 30.61353 -7.52756  -1.12985  1.000 9.81262  ? 47  PRO A N   1 
ATOM   338  C  CA  . PRO A 1 152 ? 31.03173 -7.78791  -2.52462  1.000 9.90875  ? 47  PRO A CA  1 
ATOM   339  C  C   . PRO A 1 152 ? 30.16181 -8.78716  -3.26294  1.000 9.58694  ? 47  PRO A C   1 
ATOM   340  O  O   . PRO A 1 152 ? 30.02713 -8.68652  -4.48362  1.000 10.74683 ? 47  PRO A O   1 
ATOM   341  C  CB  . PRO A 1 152 ? 32.47047 -8.32209  -2.35229  1.000 15.69533 ? 47  PRO A CB  1 
ATOM   342  C  CG  . PRO A 1 152 ? 32.92433 -7.67545  -1.11904  1.000 14.41168 ? 47  PRO A CG  1 
ATOM   343  C  CD  . PRO A 1 152 ? 31.73919 -7.61082  -0.16182  1.000 10.61835 ? 47  PRO A CD  1 
ATOM   344  N  N   . GLU A 1 153 ? 29.52280 -9.72552  -2.55170  1.000 9.05569  ? 48  GLU A N   1 
ATOM   345  C  CA  . GLU A 1 153 ? 28.70372 -10.74041 -3.18843  1.000 7.11776  ? 48  GLU A CA  1 
ATOM   346  C  C   . GLU A 1 153 ? 27.43222 -10.18816 -3.80091  1.000 8.63855  ? 48  GLU A C   1 
ATOM   347  O  O   . GLU A 1 153 ? 26.82651 -10.89977 -4.59800  1.000 9.20036  ? 48  GLU A O   1 
ATOM   348  C  CB  . GLU A 1 153 ? 28.33985 -11.80047 -2.12659  1.000 8.18739  ? 48  GLU A CB  1 
ATOM   349  C  CG  . GLU A 1 153 ? 29.47674 -12.79624 -1.88175  1.000 10.61091 ? 48  GLU A CG  1 
ATOM   350  C  CD  . GLU A 1 153 ? 29.50034 -13.82594 -2.94866  1.000 18.47766 ? 48  GLU A CD  1 
ATOM   351  O  OE1 . GLU A 1 153 ? 28.41253 -14.11372 -3.49928  1.000 19.35006 ? 48  GLU A OE1 1 
ATOM   352  O  OE2 . GLU A 1 153 ? 30.57766 -14.35273 -3.22925  1.000 20.55233 ? 48  GLU A OE2 1 
ATOM   353  N  N   . PHE A 1 154 ? 27.03982 -8.96144  -3.48075  1.000 9.67467  ? 49  PHE A N   1 
ATOM   354  C  CA  . PHE A 1 154 ? 25.83969 -8.42576  -4.12638  1.000 8.10519  ? 49  PHE A CA  1 
ATOM   355  C  C   . PHE A 1 154 ? 26.17449 -7.62280  -5.37276  1.000 10.87667 ? 49  PHE A C   1 
ATOM   356  O  O   . PHE A 1 154 ? 25.26202 -7.32027  -6.13512  1.000 9.91284  ? 49  PHE A O   1 
ATOM   357  C  CB  . PHE A 1 154 ? 25.05904 -7.52563  -3.16366  1.000 8.14826  ? 49  PHE A CB  1 
ATOM   358  C  CG  . PHE A 1 154 ? 24.48136 -8.28897  -1.99807  1.000 9.01166  ? 49  PHE A CG  1 
ATOM   359  C  CD1 . PHE A 1 154 ? 23.62317 -9.34537  -2.23957  1.000 9.82708  ? 49  PHE A CD1 1 
ATOM   360  C  CD2 . PHE A 1 154 ? 24.82560 -7.98664  -0.71347  1.000 8.23226  ? 49  PHE A CD2 1 
ATOM   361  C  CE1 . PHE A 1 154 ? 23.09150 -10.12829 -1.13961  1.000 11.03179 ? 49  PHE A CE1 1 
ATOM   362  C  CE2 . PHE A 1 154 ? 24.28957 -8.74185  0.38203   1.000 11.20719 ? 49  PHE A CE2 1 
ATOM   363  C  CZ  . PHE A 1 154 ? 23.41919 -9.81386  0.14103   1.000 8.67073  ? 49  PHE A CZ  1 
ATOM   364  N  N   . GLU A 1 155 ? 27.45563 -7.28756  -5.61087  1.000 9.55227  ? 50  GLU A N   1 
ATOM   365  C  CA  . GLU A 1 155 ? 27.89800 -6.72779  -6.91337  1.000 8.46623  ? 50  GLU A CA  1 
ATOM   366  C  C   . GLU A 1 155 ? 27.19467 -5.42698  -7.24742  1.000 9.70662  ? 50  GLU A C   1 
ATOM   367  O  O   . GLU A 1 155 ? 27.02864 -5.10293  -8.43055  1.000 13.40781 ? 50  GLU A O   1 
ATOM   368  C  CB  . GLU A 1 155 ? 27.72610 -7.71658  -8.06554  1.000 10.13772 ? 50  GLU A CB  1 
ATOM   369  C  CG  . GLU A 1 155 ? 28.33759 -9.12153  -7.82984  1.000 13.04000 ? 50  GLU A CG  1 
ATOM   370  C  CD  . GLU A 1 155 ? 28.05937 -10.04881 -8.96424  1.000 18.93237 ? 50  GLU A CD  1 
ATOM   371  O  OE1 . GLU A 1 155 ? 26.88248 -10.33254 -9.19870  1.000 15.16992 ? 50  GLU A OE1 1 
ATOM   372  O  OE2 . GLU A 1 155 ? 29.02017 -10.49342 -9.67217  1.000 17.04145 ? 50  GLU A OE2 1 
ATOM   373  N  N   . GLY A 1 156 ? 26.80378 -4.66513  -6.23844  1.000 10.91965 ? 51  GLY A N   1 
ATOM   374  C  CA  . GLY A 1 156 ? 26.11747 -3.40987  -6.46980  1.000 12.58453 ? 51  GLY A CA  1 
ATOM   375  C  C   . GLY A 1 156 ? 24.63043 -3.52936  -6.75299  1.000 13.05781 ? 51  GLY A C   1 
ATOM   376  O  O   . GLY A 1 156 ? 23.98264 -2.50424  -7.05817  1.000 12.82426 ? 51  GLY A O   1 
ATOM   377  N  N   . ARG A 1 157 ? 24.08209 -4.74254  -6.70175  1.000 7.92555  ? 52  ARG A N   1 
ATOM   378  C  CA  . ARG A 1 157 ? 22.67182 -4.97745  -7.05582  1.000 6.13753  ? 52  ARG A CA  1 
ATOM   379  C  C   . ARG A 1 157 ? 21.73484 -4.88618  -5.85399  1.000 12.67427 ? 52  ARG A C   1 
ATOM   380  O  O   . ARG A 1 157 ? 20.52375 -5.15226  -6.01544  1.000 12.48675 ? 52  ARG A O   1 
ATOM   381  C  CB  . ARG A 1 157 ? 22.50049 -6.34487  -7.69801  1.000 9.53879  ? 52  ARG A CB  1 
ATOM   382  C  CG  . ARG A 1 157 ? 23.17932 -6.47031  -9.08986  1.000 8.51647  ? 52  ARG A CG  1 
ATOM   383  C  CD  . ARG A 1 157 ? 23.06089 -7.86709  -9.66454  1.000 9.97052  ? 52  ARG A CD  1 
ATOM   384  N  NE  . ARG A 1 157 ? 23.95196 -8.82516  -8.98050  1.000 9.59898  ? 52  ARG A NE  1 
ATOM   385  C  CZ  . ARG A 1 157 ? 23.54414 -9.72017  -8.08026  1.000 10.14243 ? 52  ARG A CZ  1 
ATOM   386  N  NH1 . ARG A 1 157 ? 22.25807 -9.81842  -7.69394  1.000 9.59799  ? 52  ARG A NH1 1 
ATOM   387  N  NH2 . ARG A 1 157 ? 24.44554 -10.54313 -7.51443  1.000 8.90658  ? 52  ARG A NH2 1 
ATOM   388  N  N   . ALA A 1 158 ? 22.23455 -4.52559  -4.68558  1.000 10.20400 ? 53  ALA A N   1 
ATOM   389  C  CA  . ALA A 1 158 ? 21.38905 -4.40996  -3.47630  1.000 8.76508  ? 53  ALA A CA  1 
ATOM   390  C  C   . ALA A 1 158 ? 21.34712 -2.96895  -2.98703  1.000 10.75026 ? 53  ALA A C   1 
ATOM   391  O  O   . ALA A 1 158 ? 22.35691 -2.24788  -3.04264  1.000 12.85502 ? 53  ALA A O   1 
ATOM   392  C  CB  . ALA A 1 158 ? 21.86881 -5.32433  -2.30752  1.000 10.18631 ? 53  ALA A CB  1 
ATOM   393  N  N   . GLN A 1 159 ? 20.18867 -2.55513  -2.48870  1.000 9.03824  ? 54  GLN A N   1 
ATOM   394  C  CA  . GLN A 1 159 ? 20.05695 -1.21606  -1.94125  1.000 10.59268 ? 54  GLN A CA  1 
ATOM   395  C  C   . GLN A 1 159 ? 19.03090 -1.24925  -0.83161  1.000 11.28067 ? 54  GLN A C   1 
ATOM   396  O  O   . GLN A 1 159 ? 18.02494 -1.93750  -0.94522  1.000 11.99781 ? 54  GLN A O   1 
ATOM   397  C  CB  . GLN A 1 159 ? 19.65987 -0.29904  -3.10409  1.000 17.64861 ? 54  GLN A CB  1 
ATOM   398  C  CG  . GLN A 1 159 ? 19.06874 1.03539   -2.88315  1.000 40.56202 ? 54  GLN A CG  1 
ATOM   399  C  CD  . GLN A 1 159 ? 18.46705 1.52966   -4.19924  1.000 41.34660 ? 54  GLN A CD  1 
ATOM   400  O  OE1 . GLN A 1 159 ? 18.96174 1.16832   -5.27920  1.000 49.54341 ? 54  GLN A OE1 1 
ATOM   401  N  NE2 . GLN A 1 159 ? 17.47796 2.42011   -4.12121  1.000 57.91891 ? 54  GLN A NE2 1 
ATOM   402  N  N   . MET A 1 160 ? 19.30740 -0.53436  0.26428   1.000 9.72589  ? 55  MET A N   1 
ATOM   403  C  CA  . MET A 1 160 ? 18.26113 -0.26755  1.24984   1.000 6.70588  ? 55  MET A CA  1 
ATOM   404  C  C   . MET A 1 160 ? 17.34206 0.82318   0.78051   1.000 13.08392 ? 55  MET A C   1 
ATOM   405  O  O   . MET A 1 160 ? 17.81734 1.88058   0.32266   1.000 14.99983 ? 55  MET A O   1 
ATOM   406  C  CB  . MET A 1 160 ? 18.89263 0.17033   2.57965   1.000 9.67863  ? 55  MET A CB  1 
ATOM   407  C  CG  . MET A 1 160 ? 19.62746 -0.88752  3.40445   1.000 11.14744 ? 55  MET A CG  1 
ATOM   408  S  SD  . MET A 1 160 ? 18.56678 -2.32117  3.75821   1.000 10.24867 ? 55  MET A SD  1 
ATOM   409  C  CE  . MET A 1 160 ? 17.45524 -1.56250  4.85090   1.000 11.43456 ? 55  MET A CE  1 
ATOM   410  N  N   . VAL A 1 161 ? 16.03832 0.59329   0.91527   1.000 8.57824  ? 56  VAL A N   1 
ATOM   411  C  CA  . VAL A 1 161 ? 15.05443 1.58247   0.50278   1.000 7.00047  ? 56  VAL A CA  1 
ATOM   412  C  C   . VAL A 1 161 ? 14.21578 2.10467   1.64354   1.000 10.15103 ? 56  VAL A C   1 
ATOM   413  O  O   . VAL A 1 161 ? 13.59227 3.16357   1.48202   1.000 13.19858 ? 56  VAL A O   1 
ATOM   414  C  CB  . VAL A 1 161 ? 14.14318 1.06706   -0.62645  1.000 9.35261  ? 56  VAL A CB  1 
ATOM   415  C  CG1 . VAL A 1 161 ? 14.98519 0.78354   -1.89913  1.000 14.60973 ? 56  VAL A CG1 1 
ATOM   416  C  CG2 . VAL A 1 161 ? 13.33658 -0.14696  -0.17900  1.000 13.89729 ? 56  VAL A CG2 1 
ATOM   417  N  N   . LYS A 1 162 ? 14.18989 1.45414   2.82410   1.000 8.98189  ? 57  LYS A N   1 
ATOM   418  C  CA  . LYS A 1 162 ? 13.35861 1.96267   3.91635   1.000 8.20309  ? 57  LYS A CA  1 
ATOM   419  C  C   . LYS A 1 162 ? 13.81527 1.33353   5.21241   1.000 9.49359  ? 57  LYS A C   1 
ATOM   420  O  O   . LYS A 1 162 ? 14.09912 0.15262   5.24050   1.000 10.91521 ? 57  LYS A O   1 
ATOM   421  C  CB  . LYS A 1 162 ? 11.87264 1.57901   3.65757   1.000 11.25826 ? 57  LYS A CB  1 
ATOM   422  C  CG  . LYS A 1 162 ? 10.90562 1.96799   4.76817   1.000 11.30535 ? 57  LYS A CG  1 
ATOM   423  C  CD  . LYS A 1 162 ? 10.66926 3.48934   4.76020   1.000 13.55291 ? 57  LYS A CD  1 
ATOM   424  C  CE  . LYS A 1 162 ? 9.62217  3.81776   5.78512   1.000 22.58608 ? 57  LYS A CE  1 
ATOM   425  N  NZ  . LYS A 1 162 ? 9.62822  5.26948   6.12658   1.000 29.85684 ? 57  LYS A NZ  1 
ATOM   426  N  N   . THR A 1 163 ? 13.84172 2.11651   6.28871   1.000 9.75300  ? 58  THR A N   1 
ATOM   427  C  CA  . THR A 1 163 ? 14.05407 1.57365   7.62017   1.000 9.77795  ? 58  THR A CA  1 
ATOM   428  C  C   . THR A 1 163 ? 13.02363 2.16470   8.58104   1.000 10.97505 ? 58  THR A C   1 
ATOM   429  O  O   . THR A 1 163 ? 12.53819 3.29715   8.39581   1.000 13.44052 ? 58  THR A O   1 
ATOM   430  C  CB  . THR A 1 163 ? 15.47215 1.83115   8.12598   1.000 9.55038  ? 58  THR A CB  1 
ATOM   431  O  OG1 . THR A 1 163 ? 15.59138 1.24553   9.43335   1.000 9.83475  ? 58  THR A OG1 1 
ATOM   432  C  CG2 . THR A 1 163 ? 15.78714 3.35429   8.24051   1.000 10.81791 ? 58  THR A CG2 1 
ATOM   433  N  N   . TYR A 1 164 ? 12.67019 1.37695   9.59552   1.000 8.78925  ? 59  TYR A N   1 
ATOM   434  C  CA  . TYR A 1 164 ? 11.76392 1.80497   10.64847  1.000 7.06420  ? 59  TYR A CA  1 
ATOM   435  C  C   . TYR A 1 164 ? 12.49874 2.01940   11.95336  1.000 9.29334  ? 59  TYR A C   1 
ATOM   436  O  O   . TYR A 1 164 ? 11.86320 2.13328   13.01142  1.000 13.27925 ? 59  TYR A O   1 
ATOM   437  C  CB  . TYR A 1 164 ? 10.60266 0.79227   10.82758  1.000 11.12634 ? 59  TYR A CB  1 
ATOM   438  C  CG  . TYR A 1 164 ? 9.69657  0.83186   9.63032   1.000 8.86253  ? 59  TYR A CG  1 
ATOM   439  C  CD1 . TYR A 1 164 ? 8.66092  1.75363   9.55806   1.000 13.13927 ? 59  TYR A CD1 1 
ATOM   440  C  CD2 . TYR A 1 164 ? 9.89018  -0.03424  8.55117   1.000 9.17237  ? 59  TYR A CD2 1 
ATOM   441  C  CE1 . TYR A 1 164 ? 7.84057  1.85377   8.43139   1.000 12.12060 ? 59  TYR A CE1 1 
ATOM   442  C  CE2 . TYR A 1 164 ? 9.06208  0.07737   7.39969   1.000 9.96492  ? 59  TYR A CE2 1 
ATOM   443  C  CZ  . TYR A 1 164 ? 8.03914  0.99347   7.37578   1.000 12.23781 ? 59  TYR A CZ  1 
ATOM   444  O  OH  . TYR A 1 164 ? 7.22999  1.10238   6.25653   1.000 13.44402 ? 59  TYR A OH  1 
ATOM   445  N  N   . TYR A 1 165 ? 13.83500 2.03173   11.91491  1.000 11.17186 ? 60  TYR A N   1 
ATOM   446  C  CA  . TYR A 1 165 ? 14.64341 2.27632   13.09737  1.000 10.25786 ? 60  TYR A CA  1 
ATOM   447  C  C   . TYR A 1 165 ? 15.64968 3.39098   12.83444  1.000 12.24951 ? 60  TYR A C   1 
ATOM   448  O  O   . TYR A 1 165 ? 15.55040 4.11822   11.84097  1.000 16.24273 ? 60  TYR A O   1 
ATOM   449  C  CB  . TYR A 1 165 ? 15.39094 0.98302   13.50943  1.000 12.17909 ? 60  TYR A CB  1 
ATOM   450  C  CG  . TYR A 1 165 ? 14.37785 -0.09926  13.78524  1.000 13.23561 ? 60  TYR A CG  1 
ATOM   451  C  CD1 . TYR A 1 165 ? 13.84126 -0.25661  15.03918  1.000 14.22497 ? 60  TYR A CD1 1 
ATOM   452  C  CD2 . TYR A 1 165 ? 13.92067 -0.91988  12.75427  1.000 17.65657 ? 60  TYR A CD2 1 
ATOM   453  C  CE1 . TYR A 1 165 ? 12.83983 -1.25384  15.28310  1.000 16.71645 ? 60  TYR A CE1 1 
ATOM   454  C  CE2 . TYR A 1 165 ? 12.94880 -1.88488  12.96089  1.000 13.92426 ? 60  TYR A CE2 1 
ATOM   455  C  CZ  . TYR A 1 165 ? 12.41104 -2.03792  14.19508  1.000 12.03324 ? 60  TYR A CZ  1 
ATOM   456  O  OH  . TYR A 1 165 ? 11.41449 -3.00732  14.32966  1.000 18.91233 ? 60  TYR A OH  1 
ATOM   457  N  N   . TYR A 1 166 ? 16.62522 3.53084   13.73366  1.000 11.49799 ? 61  TYR A N   1 
ATOM   458  C  CA  . TYR A 1 166 ? 17.49513 4.71681   13.68022  1.000 11.49489 ? 61  TYR A CA  1 
ATOM   459  C  C   . TYR A 1 166 ? 18.43722 4.68913   12.50680  1.000 15.54882 ? 61  TYR A C   1 
ATOM   460  O  O   . TYR A 1 166 ? 18.85890 5.74812   12.03574  1.000 19.09604 ? 61  TYR A O   1 
ATOM   461  C  CB  . TYR A 1 166 ? 18.30597 4.82112   14.95778  1.000 13.13794 ? 61  TYR A CB  1 
ATOM   462  C  CG  . TYR A 1 166 ? 17.49407 4.69117   16.18467  1.000 18.50945 ? 61  TYR A CG  1 
ATOM   463  C  CD1 . TYR A 1 166 ? 16.80710 5.80562   16.73225  1.000 17.47125 ? 61  TYR A CD1 1 
ATOM   464  C  CD2 . TYR A 1 166 ? 17.37424 3.46696   16.83319  1.000 19.23468 ? 61  TYR A CD2 1 
ATOM   465  C  CE1 . TYR A 1 166 ? 16.02926 5.67718   17.90014  1.000 16.41240 ? 61  TYR A CE1 1 
ATOM   466  C  CE2 . TYR A 1 166 ? 16.59180 3.34363   17.98429  1.000 19.23459 ? 61  TYR A CE2 1 
ATOM   467  C  CZ  . TYR A 1 166 ? 15.93567 4.43849   18.50871  1.000 20.98064 ? 61  TYR A CZ  1 
ATOM   468  O  OH  . TYR A 1 166 ? 15.16797 4.23287   19.64793  1.000 23.93380 ? 61  TYR A OH  1 
ATOM   469  N  N   . SER A 1 167 ? 18.79677 3.48661   12.03449  1.000 13.27160 ? 62  SER A N   1 
ATOM   470  C  CA  . SER A 1 167 ? 19.72008 3.31414   10.93324  1.000 13.94024 ? 62  SER A CA  1 
ATOM   471  C  C   . SER A 1 167 ? 19.12960 2.29625   9.97160   1.000 13.19386 ? 62  SER A C   1 
ATOM   472  O  O   . SER A 1 167 ? 18.22675 1.52996   10.33929  1.000 14.16180 ? 62  SER A O   1 
ATOM   473  C  CB  . SER A 1 167 ? 21.06224 2.78317   11.45695  1.000 18.20078 ? 62  SER A CB  1 
ATOM   474  O  OG  . SER A 1 167 ? 21.94492 2.48008   10.42414  1.000 19.67713 ? 62  SER A OG  1 
ATOM   475  N  N   A SER A 1 168 ? 19.64253 2.31008   8.74953   0.566 13.66649 ? 63  SER A N   1 
ATOM   476  N  N   B SER A 1 168 ? 19.63728 2.31422   8.73693   0.434 13.64727 ? 63  SER A N   1 
ATOM   477  C  CA  A SER A 1 168 ? 19.32178 1.28252   7.77390   0.566 13.08624 ? 63  SER A CA  1 
ATOM   478  C  CA  B SER A 1 168 ? 19.29355 1.31193   7.73367   0.434 13.08115 ? 63  SER A CA  1 
ATOM   479  C  C   A SER A 1 168 ? 20.33686 0.15528   7.76770   0.566 12.25283 ? 63  SER A C   1 
ATOM   480  C  C   B SER A 1 168 ? 20.15291 0.06668   7.82279   0.434 12.11448 ? 63  SER A C   1 
ATOM   481  O  O   A SER A 1 168 ? 20.30141 -0.68320  6.86026   0.566 10.66280 ? 63  SER A O   1 
ATOM   482  O  O   B SER A 1 168 ? 19.78181 -0.97700  7.26162   0.434 10.07219 ? 63  SER A O   1 
ATOM   483  C  CB  A SER A 1 168 ? 19.24751 1.88773   6.37648   0.566 15.12999 ? 63  SER A CB  1 
ATOM   484  C  CB  B SER A 1 168 ? 19.45524 1.88551   6.32392   0.434 14.98419 ? 63  SER A CB  1 
ATOM   485  O  OG  A SER A 1 168 ? 20.51619 2.38276   6.01864   0.566 15.34196 ? 63  SER A OG  1 
ATOM   486  O  OG  B SER A 1 168 ? 18.62118 3.01057   6.14348   0.434 18.57989 ? 63  SER A OG  1 
ATOM   487  N  N   A ARG A 1 169 ? 21.23712 0.10272   8.74864   0.566 12.04074 ? 64  ARG A N   1 
ATOM   488  N  N   B ARG A 1 169 ? 21.30741 0.15915   8.47285   0.434 12.31057 ? 64  ARG A N   1 
ATOM   489  C  CA  A ARG A 1 169 ? 22.27972 -0.91392  8.77007   0.566 13.51030 ? 64  ARG A CA  1 
ATOM   490  C  CA  B ARG A 1 169 ? 22.26089 -0.93724  8.48466   0.434 12.92293 ? 64  ARG A CA  1 
ATOM   491  C  C   A ARG A 1 169 ? 21.74346 -2.23694  9.29242   0.566 9.67070  ? 64  ARG A C   1 
ATOM   492  C  C   B ARG A 1 169 ? 21.64689 -2.19080  9.09875   0.434 9.57615  ? 64  ARG A C   1 
ATOM   493  O  O   A ARG A 1 169 ? 21.02788 -2.27362  10.30196  0.566 9.78805  ? 64  ARG A O   1 
ATOM   494  O  O   B ARG A 1 169 ? 20.77345 -2.13107  9.96791   0.434 11.88045 ? 64  ARG A O   1 
ATOM   495  C  CB  A ARG A 1 169 ? 23.44132 -0.44355  9.66366   0.566 13.59015 ? 64  ARG A CB  1 
ATOM   496  C  CB  B ARG A 1 169 ? 23.50014 -0.51690  9.28582   0.434 14.99974 ? 64  ARG A CB  1 
ATOM   497  C  CG  A ARG A 1 169 ? 24.64548 -1.35034  9.62679   0.566 18.57830 ? 64  ARG A CG  1 
ATOM   498  C  CG  B ARG A 1 169 ? 24.39230 0.46047   8.53757   0.434 18.24880 ? 64  ARG A CG  1 
ATOM   499  C  CD  A ARG A 1 169 ? 25.76631 -0.87962  10.59513  0.566 20.09731 ? 64  ARG A CD  1 
ATOM   500  C  CD  B ARG A 1 169 ? 25.77614 0.56548   9.18484   0.434 27.99635 ? 64  ARG A CD  1 
ATOM   501  N  NE  A ARG A 1 169 ? 25.26213 -0.82685  11.95481  0.566 30.90612 ? 64  ARG A NE  1 
ATOM   502  N  NE  B ARG A 1 169 ? 25.73865 1.14162   10.52369  0.434 30.45129 ? 64  ARG A NE  1 
ATOM   503  C  CZ  A ARG A 1 169 ? 25.60929 -1.68676  12.90172  0.566 34.61468 ? 64  ARG A CZ  1 
ATOM   504  C  CZ  B ARG A 1 169 ? 25.51086 2.42173   10.79592  0.434 31.68577 ? 64  ARG A CZ  1 
ATOM   505  N  NH1 A ARG A 1 169 ? 26.55386 -2.59637  12.69788  0.566 31.67935 ? 64  ARG A NH1 1 
ATOM   506  N  NH1 B ARG A 1 169 ? 25.36159 3.31979   9.83588   0.434 39.02399 ? 64  ARG A NH1 1 
ATOM   507  N  NH2 A ARG A 1 169 ? 24.98980 -1.63720  14.07703  0.566 33.25179 ? 64  ARG A NH2 1 
ATOM   508  N  NH2 B ARG A 1 169 ? 25.43166 2.81007   12.06492  0.434 34.92892 ? 64  ARG A NH2 1 
ATOM   509  N  N   . ASP A 1 170 ? 22.12900 -3.33967  8.63775   1.000 8.17055  ? 65  ASP A N   1 
ATOM   510  C  CA  . ASP A 1 170 ? 21.84937 -4.64301  9.24912   1.000 9.23394  ? 65  ASP A CA  1 
ATOM   511  C  C   . ASP A 1 170 ? 22.88857 -4.88201  10.35336  1.000 10.22378 ? 65  ASP A C   1 
ATOM   512  O  O   . ASP A 1 170 ? 24.04873 -5.23340  10.07859  1.000 10.90279 ? 65  ASP A O   1 
ATOM   513  C  CB  . ASP A 1 170 ? 21.90089 -5.72759  8.18666   1.000 8.97107  ? 65  ASP A CB  1 
ATOM   514  C  CG  . ASP A 1 170 ? 21.62436 -7.12458  8.74159   1.000 9.76803  ? 65  ASP A CG  1 
ATOM   515  O  OD1 . ASP A 1 170 ? 21.17140 -7.23474  9.88107   1.000 8.80805  ? 65  ASP A OD1 1 
ATOM   516  O  OD2 . ASP A 1 170 ? 21.85868 -8.10343  7.99342   1.000 9.04427  ? 65  ASP A OD2 1 
ATOM   517  N  N   . GLY A 1 171 ? 22.46355 -4.70669  11.59703  1.000 8.77823  ? 66  GLY A N   1 
ATOM   518  C  CA  . GLY A 1 171 ? 23.33807 -4.99060  12.71937  1.000 10.71282 ? 66  GLY A CA  1 
ATOM   519  C  C   . GLY A 1 171 ? 23.21979 -6.40189  13.22630  1.000 10.77241 ? 66  GLY A C   1 
ATOM   520  O  O   . GLY A 1 171 ? 23.77025 -6.74182  14.27589  1.000 14.99541 ? 66  GLY A O   1 
ATOM   521  N  N   . ASN A 1 172 ? 22.38504 -7.21859  12.60121  1.000 9.54513  ? 67  ASN A N   1 
ATOM   522  C  CA  . ASN A 1 172 ? 22.11692 -8.57250  13.06486  1.000 8.73510  ? 67  ASN A CA  1 
ATOM   523  C  C   . ASN A 1 172 ? 22.77400 -9.63251  12.19691  1.000 11.17686 ? 67  ASN A C   1 
ATOM   524  O  O   . ASN A 1 172 ? 23.49729 -10.51505 12.70447  1.000 12.27817 ? 67  ASN A O   1 
ATOM   525  C  CB  . ASN A 1 172 ? 20.59387 -8.79732  13.09538  1.000 9.94213  ? 67  ASN A CB  1 
ATOM   526  C  CG  . ASN A 1 172 ? 20.20058 -10.17936 13.58984  1.000 14.04933 ? 67  ASN A CG  1 
ATOM   527  O  OD1 . ASN A 1 172 ? 20.19808 -11.16084 12.83756  1.000 11.06429 ? 67  ASN A OD1 1 
ATOM   528  N  ND2 . ASN A 1 172 ? 19.89490 -10.28555 14.90392  1.000 15.32347 ? 67  ASN A ND2 1 
ATOM   529  N  N   . GLY A 1 173 ? 22.52635 -9.59794  10.88050  1.000 9.33212  ? 68  GLY A N   1 
ATOM   530  C  CA  . GLY A 1 173 ? 23.03354 -10.59519 9.95376   1.000 6.61218  ? 68  GLY A CA  1 
ATOM   531  C  C   . GLY A 1 173 ? 21.92067 -11.35754 9.24274   1.000 7.30761  ? 68  GLY A C   1 
ATOM   532  O  O   . GLY A 1 173 ? 22.10854 -11.77959 8.10166   1.000 8.16729  ? 68  GLY A O   1 
ATOM   533  N  N   . HIS A 1 174 ? 20.78598 -11.57709 9.91733   1.000 7.93033  ? 69  HIS A N   1 
ATOM   534  C  CA  . HIS A 1 174 ? 19.71730 -12.41730 9.36058   1.000 7.13504  ? 69  HIS A CA  1 
ATOM   535  C  C   . HIS A 1 174 ? 19.25306 -11.92829 7.97710   1.000 8.21249  ? 69  HIS A C   1 
ATOM   536  O  O   . HIS A 1 174 ? 19.13921 -12.71529 7.02446   1.000 6.69380  ? 69  HIS A O   1 
ATOM   537  C  CB  . HIS A 1 174 ? 18.56378 -12.39298 10.35229  1.000 7.19656  ? 69  HIS A CB  1 
ATOM   538  C  CG  . HIS A 1 174 ? 17.42767 -13.31688 10.05465  1.000 7.01142  ? 69  HIS A CG  1 
ATOM   539  N  ND1 . HIS A 1 174 ? 16.29838 -12.89971 9.37796   1.000 8.03711  ? 69  HIS A ND1 1 
ATOM   540  C  CD2 . HIS A 1 174 ? 17.21156 -14.62463 10.39610  1.000 12.05748 ? 69  HIS A CD2 1 
ATOM   541  C  CE1 . HIS A 1 174 ? 15.41881 -13.90479 9.33882   1.000 9.81327  ? 69  HIS A CE1 1 
ATOM   542  N  NE2 . HIS A 1 174 ? 15.93775 -14.94435 9.98392   1.000 10.57558 ? 69  HIS A NE2 1 
ATOM   543  N  N   . GLY A 1 175 ? 18.99105 -10.62499 7.85495   1.000 7.45847  ? 70  GLY A N   1 
ATOM   544  C  CA  . GLY A 1 175 ? 18.49778 -10.11020 6.57614   1.000 9.00918  ? 70  GLY A CA  1 
ATOM   545  C  C   . GLY A 1 175 ? 19.53614 -10.22014 5.46678   1.000 7.59735  ? 70  GLY A C   1 
ATOM   546  O  O   . GLY A 1 175 ? 19.19887 -10.53320 4.30377   1.000 6.31537  ? 70  GLY A O   1 
ATOM   547  N  N   . THR A 1 176 ? 20.81607 -10.01237 5.80245   1.000 5.13769  ? 71  THR A N   1 
ATOM   548  C  CA  . THR A 1 176 ? 21.88588 -10.17787 4.80903   1.000 5.40710  ? 71  THR A CA  1 
ATOM   549  C  C   . THR A 1 176 ? 22.04020 -11.64165 4.36386   1.000 6.11387  ? 71  THR A C   1 
ATOM   550  O  O   . THR A 1 176 ? 22.23704 -11.91514 3.16771   1.000 6.57294  ? 71  THR A O   1 
ATOM   551  C  CB  . THR A 1 176 ? 23.18476 -9.63924  5.43591   1.000 5.76729  ? 71  THR A CB  1 
ATOM   552  O  OG1 . THR A 1 176 ? 23.05860 -8.22816  5.62327   1.000 8.33133  ? 71  THR A OG1 1 
ATOM   553  C  CG2 . THR A 1 176 ? 24.40555 -9.97241  4.56540   1.000 8.98752  ? 71  THR A CG2 1 
ATOM   554  N  N   . HIS A 1 177 ? 21.84334 -12.60549 5.29372   1.000 6.03295  ? 72  HIS A N   1 
ATOM   555  C  CA  . HIS A 1 177 ? 21.87292 -14.01435 4.92003   1.000 4.86383  ? 72  HIS A CA  1 
ATOM   556  C  C   . HIS A 1 177 ? 20.73124 -14.36345 3.97428   1.000 4.56892  ? 72  HIS A C   1 
ATOM   557  O  O   . HIS A 1 177 ? 20.93405 -14.97211 2.92073   1.000 6.16639  ? 72  HIS A O   1 
ATOM   558  C  CB  . HIS A 1 177 ? 21.78551 -14.84167 6.22002   1.000 7.11706  ? 72  HIS A CB  1 
ATOM   559  C  CG  . HIS A 1 177 ? 22.17866 -16.27753 6.05924   1.000 7.38305  ? 72  HIS A CG  1 
ATOM   560  N  ND1 . HIS A 1 177 ? 21.28727 -17.24481 5.62930   1.000 8.12332  ? 72  HIS A ND1 1 
ATOM   561  C  CD2 . HIS A 1 177 ? 23.36347 -16.91725 6.30179   1.000 7.68326  ? 72  HIS A CD2 1 
ATOM   562  C  CE1 . HIS A 1 177 ? 21.91462 -18.41301 5.58200   1.000 7.33162  ? 72  HIS A CE1 1 
ATOM   563  N  NE2 . HIS A 1 177 ? 23.17724 -18.23608 5.96619   1.000 6.21881  ? 72  HIS A NE2 1 
ATOM   564  N  N   . CYS A 1 178 ? 19.51822 -13.90960 4.31413   1.000 5.81821  ? 73  CYS A N   1 
ATOM   565  C  CA  . CYS A 1 178 ? 18.36253 -14.21706 3.45386   1.000 6.36988  ? 73  CYS A CA  1 
ATOM   566  C  C   . CYS A 1 178 ? 18.53711 -13.59230 2.07635   1.000 5.69638  ? 73  CYS A C   1 
ATOM   567  O  O   . CYS A 1 178 ? 18.28692 -14.24021 1.05701   1.000 6.87254  ? 73  CYS A O   1 
ATOM   568  C  CB  . CYS A 1 178 ? 17.09103 -13.68050 4.11716   1.000 7.20135  ? 73  CYS A CB  1 
ATOM   569  S  SG  . CYS A 1 178 ? 16.66228 -14.63314 5.62649   1.000 8.61718  ? 73  CYS A SG  1 
ATOM   570  N  N   . ALA A 1 179 ? 18.93788 -12.30617 2.03317   1.000 5.78812  ? 74  ALA A N   1 
ATOM   571  C  CA  . ALA A 1 179 ? 19.16183 -11.64691 0.73688   1.000 6.39682  ? 74  ALA A CA  1 
ATOM   572  C  C   . ALA A 1 179 ? 20.21888 -12.38662 -0.08126  1.000 7.53756  ? 74  ALA A C   1 
ATOM   573  O  O   . ALA A 1 179 ? 20.10973 -12.49156 -1.32464  1.000 5.84453  ? 74  ALA A O   1 
ATOM   574  C  CB  . ALA A 1 179 ? 19.58724 -10.17529 0.98575   1.000 7.23353  ? 74  ALA A CB  1 
ATOM   575  N  N   . GLY A 1 180 ? 21.26340 -12.91932 0.59164   1.000 5.89883  ? 75  GLY A N   1 
ATOM   576  C  CA  . GLY A 1 180 ? 22.27749 -13.66448 -0.16384  1.000 6.79346  ? 75  GLY A CA  1 
ATOM   577  C  C   . GLY A 1 180 ? 21.72157 -14.92834 -0.80803  1.000 5.46651  ? 75  GLY A C   1 
ATOM   578  O  O   . GLY A 1 180 ? 22.17042 -15.31354 -1.89943  1.000 7.11611  ? 75  GLY A O   1 
ATOM   579  N  N   . THR A 1 181 ? 20.75091 -15.60057 -0.14601  1.000 4.28811  ? 76  THR A N   1 
ATOM   580  C  CA  . THR A 1 181 ? 20.18600 -16.81276 -0.76493  1.000 4.53121  ? 76  THR A CA  1 
ATOM   581  C  C   . THR A 1 181 ? 19.29355 -16.43372 -1.94340  1.000 5.51866  ? 76  THR A C   1 
ATOM   582  O  O   . THR A 1 181 ? 19.16137 -17.20760 -2.91128  1.000 6.60706  ? 76  THR A O   1 
ATOM   583  C  CB  . THR A 1 181 ? 19.44466 -17.61582 0.30808   1.000 6.73296  ? 76  THR A CB  1 
ATOM   584  O  OG1 . THR A 1 181 ? 20.42120 -18.06746 1.26732   1.000 6.95281  ? 76  THR A OG1 1 
ATOM   585  C  CG2 . THR A 1 181 ? 18.71588 -18.82737 -0.26838  1.000 7.94743  ? 76  THR A CG2 1 
ATOM   586  N  N   . VAL A 1 182 ? 18.63629 -15.26171 -1.85967  1.000 6.60515  ? 77  VAL A N   1 
ATOM   587  C  CA  . VAL A 1 182 ? 17.86420 -14.77291 -3.03387  1.000 5.07837  ? 77  VAL A CA  1 
ATOM   588  C  C   . VAL A 1 182 ? 18.78906 -14.49829 -4.21608  1.000 6.23453  ? 77  VAL A C   1 
ATOM   589  O  O   . VAL A 1 182 ? 18.56568 -15.01914 -5.31511  1.000 6.50122  ? 77  VAL A O   1 
ATOM   590  C  CB  . VAL A 1 182 ? 17.09599 -13.50460 -2.69062  1.000 6.22285  ? 77  VAL A CB  1 
ATOM   591  C  CG1 . VAL A 1 182 ? 16.35965 -13.03259 -4.00868  1.000 7.31221  ? 77  VAL A CG1 1 
ATOM   592  C  CG2 . VAL A 1 182 ? 16.03254 -13.76379 -1.63482  1.000 7.74277  ? 77  VAL A CG2 1 
ATOM   593  N  N   . GLY A 1 183 ? 19.86612 -13.72916 -3.98436  1.000 7.27506  ? 78  GLY A N   1 
ATOM   594  C  CA  . GLY A 1 183 ? 20.47852 -13.05608 -5.13751  1.000 8.04845  ? 78  GLY A CA  1 
ATOM   595  C  C   . GLY A 1 183 ? 21.96959 -12.77537 -5.07601  1.000 9.88659  ? 78  GLY A C   1 
ATOM   596  O  O   . GLY A 1 183 ? 22.44087 -12.02304 -5.90621  1.000 10.56411 ? 78  GLY A O   1 
ATOM   597  N  N   . SER A 1 184 ? 22.71317 -13.29532 -4.11816  1.000 7.98837  ? 79  SER A N   1 
ATOM   598  C  CA  . SER A 1 184 ? 24.17400 -13.08095 -4.17965  1.000 6.97645  ? 79  SER A CA  1 
ATOM   599  C  C   . SER A 1 184 ? 24.78221 -13.91874 -5.30955  1.000 9.73105  ? 79  SER A C   1 
ATOM   600  O  O   . SER A 1 184 ? 24.22072 -14.89955 -5.78569  1.000 7.91073  ? 79  SER A O   1 
ATOM   601  C  CB  . SER A 1 184 ? 24.83306 -13.43069 -2.82782  1.000 7.37836  ? 79  SER A CB  1 
ATOM   602  O  OG  . SER A 1 184 ? 24.76561 -14.84891 -2.57150  1.000 8.50960  ? 79  SER A OG  1 
ATOM   603  N  N   . ARG A 1 185 ? 25.98559 -13.51495 -5.73455  1.000 6.71541  ? 80  ARG A N   1 
ATOM   604  C  CA  . ARG A 1 185 ? 26.67204 -14.21746 -6.80635  1.000 7.49741  ? 80  ARG A CA  1 
ATOM   605  C  C   . ARG A 1 185 ? 26.94536 -15.68495 -6.48510  1.000 8.59949  ? 80  ARG A C   1 
ATOM   606  O  O   . ARG A 1 185 ? 26.55799 -16.57007 -7.24360  1.000 10.41608 ? 80  ARG A O   1 
ATOM   607  C  CB  . ARG A 1 185 ? 27.95963 -13.44008 -7.14030  1.000 10.93271 ? 80  ARG A CB  1 
ATOM   608  C  CG  . ARG A 1 185 ? 28.77586 -14.12585 -8.26066  1.000 12.78357 ? 80  ARG A CG  1 
ATOM   609  C  CD  . ARG A 1 185 ? 30.24493 -13.63811 -8.21911  1.000 22.01697 ? 80  ARG A CD  1 
ATOM   610  N  NE  . ARG A 1 185 ? 30.95900 -14.40913 -7.21715  1.000 32.08517 ? 80  ARG A NE  1 
ATOM   611  C  CZ  . ARG A 1 185 ? 32.25551 -14.68689 -7.27674  1.000 57.68591 ? 80  ARG A CZ  1 
ATOM   612  N  NH1 . ARG A 1 185 ? 33.01256 -14.24153 -8.27364  1.000 45.77654 ? 80  ARG A NH1 1 
ATOM   613  N  NH2 . ARG A 1 185 ? 32.79235 -15.48023 -6.34786  1.000 40.60728 ? 80  ARG A NH2 1 
ATOM   614  N  N   . THR A 1 186 ? 27.58533 -15.97147 -5.34610  1.000 9.21160  ? 81  THR A N   1 
ATOM   615  C  CA  . THR A 1 186 ? 27.93323 -17.34326 -5.03803  1.000 7.07307  ? 81  THR A CA  1 
ATOM   616  C  C   . THR A 1 186 ? 26.82561 -18.11972 -4.35907  1.000 9.98915  ? 81  THR A C   1 
ATOM   617  O  O   . THR A 1 186 ? 26.67912 -19.31697 -4.60359  1.000 11.43061 ? 81  THR A O   1 
ATOM   618  C  CB  . THR A 1 186 ? 29.16795 -17.35370 -4.12288  1.000 8.64958  ? 81  THR A CB  1 
ATOM   619  O  OG1 . THR A 1 186 ? 30.22439 -16.62170 -4.78954  1.000 10.47955 ? 81  THR A OG1 1 
ATOM   620  C  CG2 . THR A 1 186 ? 29.64961 -18.78742 -3.85610  1.000 11.65789 ? 81  THR A CG2 1 
ATOM   621  N  N   . TYR A 1 187 ? 26.01357 -17.45660 -3.54763  1.000 6.85310  ? 82  TYR A N   1 
ATOM   622  C  CA  . TYR A 1 187 ? 25.08597 -18.19201 -2.68073  1.000 7.82940  ? 82  TYR A CA  1 
ATOM   623  C  C   . TYR A 1 187 ? 23.62951 -18.03740 -3.10943  1.000 6.89399  ? 82  TYR A C   1 
ATOM   624  O  O   . TYR A 1 187 ? 22.74324 -18.63364 -2.49125  1.000 7.19092  ? 82  TYR A O   1 
ATOM   625  C  CB  . TYR A 1 187 ? 25.25442 -17.76748 -1.17434  1.000 6.00065  ? 82  TYR A CB  1 
ATOM   626  C  CG  . TYR A 1 187 ? 26.72766 -17.78069 -0.80018  1.000 5.19187  ? 82  TYR A CG  1 
ATOM   627  C  CD1 . TYR A 1 187 ? 27.36738 -18.97307 -0.58206  1.000 11.75416 ? 82  TYR A CD1 1 
ATOM   628  C  CD2 . TYR A 1 187 ? 27.43267 -16.61316 -0.78893  1.000 9.47877  ? 82  TYR A CD2 1 
ATOM   629  C  CE1 . TYR A 1 187 ? 28.73898 -18.99620 -0.32017  1.000 9.54380  ? 82  TYR A CE1 1 
ATOM   630  C  CE2 . TYR A 1 187 ? 28.81709 -16.60568 -0.50558  1.000 10.79643 ? 82  TYR A CE2 1 
ATOM   631  C  CZ  . TYR A 1 187 ? 29.43801 -17.79823 -0.31802  1.000 12.24250 ? 82  TYR A CZ  1 
ATOM   632  O  OH  . TYR A 1 187 ? 30.82678 -17.80457 -0.04833  1.000 13.75662 ? 82  TYR A OH  1 
ATOM   633  N  N   . GLY A 1 188 ? 23.35890 -17.37712 -4.23645  1.000 7.06668  ? 83  GLY A N   1 
ATOM   634  C  CA  . GLY A 1 188 ? 21.99796 -16.96556 -4.58196  1.000 8.05901  ? 83  GLY A CA  1 
ATOM   635  C  C   . GLY A 1 188 ? 21.36621 -17.82819 -5.65920  1.000 9.49798  ? 83  GLY A C   1 
ATOM   636  O  O   . GLY A 1 188 ? 22.03585 -18.34142 -6.55384  1.000 8.88494  ? 83  GLY A O   1 
ATOM   637  N  N   . VAL A 1 189 ? 20.03588 -17.90302 -5.60413  1.000 4.74756  ? 84  VAL A N   1 
ATOM   638  C  CA  . VAL A 1 189 ? 19.26972 -18.59131 -6.64553  1.000 7.64967  ? 84  VAL A CA  1 
ATOM   639  C  C   . VAL A 1 189 ? 19.22493 -17.76012 -7.92500  1.000 8.73601  ? 84  VAL A C   1 
ATOM   640  O  O   . VAL A 1 189 ? 19.35498 -18.29620 -9.04134  1.000 10.37152 ? 84  VAL A O   1 
ATOM   641  C  CB  . VAL A 1 189 ? 17.84629 -18.84041 -6.12576  1.000 5.52559  ? 84  VAL A CB  1 
ATOM   642  C  CG1 . VAL A 1 189 ? 16.97164 -19.41347 -7.22688  1.000 8.13340  ? 84  VAL A CG1 1 
ATOM   643  C  CG2 . VAL A 1 189 ? 17.89051 -19.82611 -4.96353  1.000 7.21640  ? 84  VAL A CG2 1 
ATOM   644  N  N   . ALA A 1 190 ? 18.90761 -16.48335 -7.80426  1.000 6.95396  ? 85  ALA A N   1 
ATOM   645  C  CA  . ALA A 1 190 ? 18.66247 -15.58834 -8.93249  1.000 5.88527  ? 85  ALA A CA  1 
ATOM   646  C  C   . ALA A 1 190 ? 19.79283 -14.56321 -8.92928  1.000 7.30700  ? 85  ALA A C   1 
ATOM   647  O  O   . ALA A 1 190 ? 19.67514 -13.48354 -8.34195  1.000 7.92090  ? 85  ALA A O   1 
ATOM   648  C  CB  . ALA A 1 190 ? 17.27776 -14.90095 -8.76502  1.000 7.94509  ? 85  ALA A CB  1 
ATOM   649  N  N   . LYS A 1 191 ? 20.88976 -14.90958 -9.64642  1.000 8.24838  ? 86  LYS A N   1 
ATOM   650  C  CA  . LYS A 1 191 ? 22.16719 -14.21922 -9.44824  1.000 6.67967  ? 86  LYS A CA  1 
ATOM   651  C  C   . LYS A 1 191 ? 22.24882 -12.84383 -10.09483 1.000 11.90399 ? 86  LYS A C   1 
ATOM   652  O  O   . LYS A 1 191 ? 23.25209 -12.11865 -9.86281  1.000 10.90006 ? 86  LYS A O   1 
ATOM   653  C  CB  . LYS A 1 191 ? 23.27767 -15.12723 -9.96092  1.000 8.74351  ? 86  LYS A CB  1 
ATOM   654  C  CG  . LYS A 1 191 ? 23.38222 -16.39673 -9.12755  1.000 8.59367  ? 86  LYS A CG  1 
ATOM   655  C  CD  . LYS A 1 191 ? 24.44921 -17.33861 -9.74012  1.000 10.98350 ? 86  LYS A CD  1 
ATOM   656  C  CE  . LYS A 1 191 ? 24.49481 -18.71989 -9.05675  1.000 9.57739  ? 86  LYS A CE  1 
ATOM   657  N  NZ  . LYS A 1 191 ? 24.80693 -18.61980 -7.57404  1.000 8.20794  ? 86  LYS A NZ  1 
ATOM   658  N  N   . LYS A 1 192 ? 21.24593 -12.45868 -10.89611 1.000 8.21288  ? 87  LYS A N   1 
ATOM   659  C  CA  . LYS A 1 192 ? 21.22171 -11.13446 -11.50792 1.000 6.70603  ? 87  LYS A CA  1 
ATOM   660  C  C   . LYS A 1 192 ? 19.98879 -10.31182 -11.13673 1.000 8.77567  ? 87  LYS A C   1 
ATOM   661  O  O   . LYS A 1 192 ? 19.77313 -9.22924  -11.73149 1.000 10.49992 ? 87  LYS A O   1 
ATOM   662  C  CB  . LYS A 1 192 ? 21.34038 -11.24747 -13.03305 1.000 9.70481  ? 87  LYS A CB  1 
ATOM   663  C  CG  . LYS A 1 192 ? 22.71890 -11.76607 -13.42046 1.000 12.76295 ? 87  LYS A CG  1 
ATOM   664  C  CD  . LYS A 1 192 ? 22.63160 -12.10941 -14.93969 1.000 25.44494 ? 87  LYS A CD  1 
ATOM   665  C  CE  . LYS A 1 192 ? 24.01137 -12.46474 -15.51312 1.000 38.31408 ? 87  LYS A CE  1 
ATOM   666  N  NZ  . LYS A 1 192 ? 23.90931 -13.20131 -16.81397 1.000 39.27586 ? 87  LYS A NZ  1 
ATOM   667  N  N   . THR A 1 193 ? 19.22885 -10.71668 -10.10320 1.000 9.20882  ? 88  THR A N   1 
ATOM   668  C  CA  . THR A 1 193 ? 18.07784 -9.91622  -9.68830  1.000 9.02584  ? 88  THR A CA  1 
ATOM   669  C  C   . THR A 1 193 ? 18.52048 -8.66209  -8.94313  1.000 9.12464  ? 88  THR A C   1 
ATOM   670  O  O   . THR A 1 193 ? 19.66813 -8.53018  -8.52458  1.000 9.45364  ? 88  THR A O   1 
ATOM   671  C  CB  . THR A 1 193 ? 17.14615 -10.77459 -8.82854  1.000 10.03043 ? 88  THR A CB  1 
ATOM   672  O  OG1 . THR A 1 193 ? 15.86673 -10.14085 -8.73833  1.000 9.48775  ? 88  THR A OG1 1 
ATOM   673  C  CG2 . THR A 1 193 ? 17.66948 -10.94501 -7.40248  1.000 10.09035 ? 88  THR A CG2 1 
ATOM   674  N  N   A GLN A 1 194 ? 17.58794 -7.71026  -8.79673  0.533 6.89757  ? 89  GLN A N   1 
ATOM   675  N  N   B GLN A 1 194 ? 17.60953 -7.70345  -8.85049  0.467 6.94523  ? 89  GLN A N   1 
ATOM   676  C  CA  A GLN A 1 194 ? 17.80758 -6.47945  -8.02997  0.533 8.25140  ? 89  GLN A CA  1 
ATOM   677  C  CA  B GLN A 1 194 ? 17.82258 -6.53368  -8.01546  0.467 8.31966  ? 89  GLN A CA  1 
ATOM   678  C  C   A GLN A 1 194 ? 17.16621 -6.64286  -6.64753  0.533 8.43120  ? 89  GLN A C   1 
ATOM   679  C  C   B GLN A 1 194 ? 17.24117 -6.82778  -6.63361  0.467 8.23818  ? 89  GLN A C   1 
ATOM   680  O  O   A GLN A 1 194 ? 15.96606 -6.95901  -6.55457  0.533 8.65854  ? 89  GLN A O   1 
ATOM   681  O  O   B GLN A 1 194 ? 16.17952 -7.44748  -6.52078  0.467 8.68825  ? 89  GLN A O   1 
ATOM   682  C  CB  A GLN A 1 194 ? 17.19195 -5.27127  -8.73578  0.533 11.29504 ? 89  GLN A CB  1 
ATOM   683  C  CB  B GLN A 1 194 ? 17.16678 -5.30776  -8.64194  0.467 11.28664 ? 89  GLN A CB  1 
ATOM   684  C  CG  A GLN A 1 194 ? 16.99753 -4.04923  -7.81363  0.533 10.17092 ? 89  GLN A CG  1 
ATOM   685  C  CG  B GLN A 1 194 ? 17.86098 -4.83763  -9.92911  0.467 11.68825 ? 89  GLN A CG  1 
ATOM   686  C  CD  A GLN A 1 194 ? 18.26420 -3.18367  -7.56731  0.533 19.52141 ? 89  GLN A CD  1 
ATOM   687  C  CD  B GLN A 1 194 ? 19.16745 -4.11297  -9.63711  0.467 20.72363 ? 89  GLN A CD  1 
ATOM   688  O  OE1 A GLN A 1 194 ? 18.63361 -2.81152  -6.40781  0.533 14.73759 ? 89  GLN A OE1 1 
ATOM   689  O  OE1 B GLN A 1 194 ? 19.21531 -3.25453  -8.75411  0.467 26.34336 ? 89  GLN A OE1 1 
ATOM   690  N  NE2 A GLN A 1 194 ? 18.87195 -2.76886  -8.66337  0.533 29.65693 ? 89  GLN A NE2 1 
ATOM   691  N  NE2 B GLN A 1 194 ? 20.22245 -4.42193  -10.39804 0.467 19.70532 ? 89  GLN A NE2 1 
ATOM   692  N  N   . LEU A 1 195 ? 17.94899 -6.40310  -5.58737  1.000 7.89229  ? 90  LEU A N   1 
ATOM   693  C  CA  . LEU A 1 195 ? 17.50649 -6.60871  -4.19942  1.000 7.07469  ? 90  LEU A CA  1 
ATOM   694  C  C   . LEU A 1 195 ? 17.21947 -5.27883  -3.53458  1.000 8.95167  ? 90  LEU A C   1 
ATOM   695  O  O   . LEU A 1 195 ? 18.05887 -4.37729  -3.58843  1.000 11.03684 ? 90  LEU A O   1 
ATOM   696  C  CB  . LEU A 1 195 ? 18.59367 -7.33367  -3.37704  1.000 5.71959  ? 90  LEU A CB  1 
ATOM   697  C  CG  . LEU A 1 195 ? 18.84866 -8.73582  -3.93081  1.000 10.26289 ? 90  LEU A CG  1 
ATOM   698  C  CD1 . LEU A 1 195 ? 20.22908 -9.22703  -3.45715  1.000 18.09122 ? 90  LEU A CD1 1 
ATOM   699  C  CD2 . LEU A 1 195 ? 17.80049 -9.73640  -3.51221  1.000 14.28508 ? 90  LEU A CD2 1 
ATOM   700  N  N   . PHE A 1 196 ? 16.04643 -5.16695  -2.86442  1.000 5.72635  ? 91  PHE A N   1 
ATOM   701  C  CA  . PHE A 1 196 ? 15.68736 -3.97027  -2.11411  1.000 7.42228  ? 91  PHE A CA  1 
ATOM   702  C  C   . PHE A 1 196 ? 15.47310 -4.35249  -0.66231  1.000 9.90101  ? 91  PHE A C   1 
ATOM   703  O  O   . PHE A 1 196 ? 14.74054 -5.29942  -0.37760  1.000 10.25819 ? 91  PHE A O   1 
ATOM   704  C  CB  . PHE A 1 196 ? 14.39486 -3.36638  -2.65318  1.000 8.44079  ? 91  PHE A CB  1 
ATOM   705  C  CG  . PHE A 1 196 ? 14.49373 -2.88234  -4.06752  1.000 10.79778 ? 91  PHE A CG  1 
ATOM   706  C  CD1 . PHE A 1 196 ? 15.43058 -1.93069  -4.40686  1.000 14.21647 ? 91  PHE A CD1 1 
ATOM   707  C  CD2 . PHE A 1 196 ? 13.61895 -3.34393  -5.02245  1.000 13.51672 ? 91  PHE A CD2 1 
ATOM   708  C  CE1 . PHE A 1 196 ? 15.52374 -1.45732  -5.72957  1.000 13.18136 ? 91  PHE A CE1 1 
ATOM   709  C  CE2 . PHE A 1 196 ? 13.69101 -2.85491  -6.36197  1.000 18.90311 ? 91  PHE A CE2 1 
ATOM   710  C  CZ  . PHE A 1 196 ? 14.64715 -1.92751  -6.68386  1.000 13.29002 ? 91  PHE A CZ  1 
ATOM   711  N  N   . GLY A 1 197 ? 16.12134 -3.65929  0.26052   1.000 7.83003  ? 92  GLY A N   1 
ATOM   712  C  CA  . GLY A 1 197 ? 15.98552 -4.01267  1.67907   1.000 7.03040  ? 92  GLY A CA  1 
ATOM   713  C  C   . GLY A 1 197 ? 15.00928 -3.09533  2.39334   1.000 6.52213  ? 92  GLY A C   1 
ATOM   714  O  O   . GLY A 1 197 ? 15.02254 -1.88146  2.20738   1.000 9.16847  ? 92  GLY A O   1 
ATOM   715  N  N   . VAL A 1 198 ? 14.13116 -3.69737  3.20494   1.000 5.44429  ? 93  VAL A N   1 
ATOM   716  C  CA  . VAL A 1 198 ? 13.19789 -2.96432  4.06449   1.000 8.35997  ? 93  VAL A CA  1 
ATOM   717  C  C   . VAL A 1 198 ? 13.44329 -3.44966  5.49514   1.000 8.55717  ? 93  VAL A C   1 
ATOM   718  O  O   . VAL A 1 198 ? 13.22443 -4.63091  5.78197   1.000 8.74251  ? 93  VAL A O   1 
ATOM   719  C  CB  . VAL A 1 198 ? 11.75240 -3.20451  3.64203   1.000 8.28842  ? 93  VAL A CB  1 
ATOM   720  C  CG1 . VAL A 1 198 ? 10.80657 -2.38459  4.54292   1.000 10.23377 ? 93  VAL A CG1 1 
ATOM   721  C  CG2 . VAL A 1 198 ? 11.56731 -2.86771  2.16569   1.000 13.61667 ? 93  VAL A CG2 1 
ATOM   722  N  N   . LYS A 1 199 ? 13.94581 -2.55938  6.37280   1.000 7.06097  ? 94  LYS A N   1 
ATOM   723  C  CA  . LYS A 1 199 ? 14.29302 -2.98812  7.74441   1.000 7.71879  ? 94  LYS A CA  1 
ATOM   724  C  C   . LYS A 1 199 ? 13.08163 -2.81407  8.66926   1.000 7.73613  ? 94  LYS A C   1 
ATOM   725  O  O   . LYS A 1 199 ? 12.83016 -1.71331  9.19237   1.000 9.34030  ? 94  LYS A O   1 
ATOM   726  C  CB  . LYS A 1 199 ? 15.50303 -2.19475  8.22064   1.000 8.60679  ? 94  LYS A CB  1 
ATOM   727  C  CG  . LYS A 1 199 ? 15.95965 -2.60718  9.63126   1.000 8.49517  ? 94  LYS A CG  1 
ATOM   728  C  CD  . LYS A 1 199 ? 17.34596 -1.94206  9.95320   1.000 6.66431  ? 94  LYS A CD  1 
ATOM   729  C  CE  . LYS A 1 199 ? 17.74460 -2.17945  11.46411  1.000 10.14425 ? 94  LYS A CE  1 
ATOM   730  N  NZ  . LYS A 1 199 ? 17.88374 -3.68311  11.77442  1.000 9.16424  ? 94  LYS A NZ  1 
ATOM   731  N  N   . VAL A 1 200 ? 12.34134 -3.90076  8.87521   1.000 7.62415  ? 95  VAL A N   1 
ATOM   732  C  CA  . VAL A 1 200 ? 11.22844 -3.88540  9.82465   1.000 7.48732  ? 95  VAL A CA  1 
ATOM   733  C  C   . VAL A 1 200 ? 11.59866 -4.57201  11.13226  1.000 5.01401  ? 95  VAL A C   1 
ATOM   734  O  O   . VAL A 1 200 ? 10.81973 -4.46946  12.12029  1.000 9.39588  ? 95  VAL A O   1 
ATOM   735  C  CB  . VAL A 1 200 ? 9.95030  -4.56224  9.27886   1.000 7.48587  ? 95  VAL A CB  1 
ATOM   736  C  CG1 . VAL A 1 200 ? 9.39827  -3.85567  7.97920   1.000 9.25126  ? 95  VAL A CG1 1 
ATOM   737  C  CG2 . VAL A 1 200 ? 10.22924 -6.03776  8.96824   1.000 8.77268  ? 95  VAL A CG2 1 
ATOM   738  N  N   . LEU A 1 201 ? 12.74339 -5.25129  11.18479  1.000 8.35548  ? 96  LEU A N   1 
ATOM   739  C  CA  . LEU A 1 201 ? 13.20439 -5.92341  12.41452  1.000 8.55140  ? 96  LEU A CA  1 
ATOM   740  C  C   . LEU A 1 201 ? 14.39555 -5.18178  12.97957  1.000 9.97541  ? 96  LEU A C   1 
ATOM   741  O  O   . LEU A 1 201 ? 15.29132 -4.77885  12.23254  1.000 9.81905  ? 96  LEU A O   1 
ATOM   742  C  CB  . LEU A 1 201 ? 13.60297 -7.40079  12.14525  1.000 8.85987  ? 96  LEU A CB  1 
ATOM   743  C  CG  . LEU A 1 201 ? 12.44791 -8.27328  11.56976  1.000 9.65822  ? 96  LEU A CG  1 
ATOM   744  C  CD1 . LEU A 1 201 ? 12.94166 -9.73242  11.27239  1.000 12.14598 ? 96  LEU A CD1 1 
ATOM   745  C  CD2 . LEU A 1 201 ? 11.24187 -8.31925  12.48520  1.000 12.41783 ? 96  LEU A CD2 1 
ATOM   746  N  N   . ASP A 1 202 ? 14.44797 -5.08383  14.31355  1.000 11.92694 ? 97  ASP A N   1 
ATOM   747  C  CA  . ASP A 1 202 ? 15.60080 -4.42090  14.91150  1.000 11.83167 ? 97  ASP A CA  1 
ATOM   748  C  C   . ASP A 1 202 ? 16.83056 -5.35320  14.90486  1.000 12.05282 ? 97  ASP A C   1 
ATOM   749  O  O   . ASP A 1 202 ? 16.80803 -6.47790  14.37000  1.000 11.96102 ? 97  ASP A O   1 
ATOM   750  C  CB  . ASP A 1 202 ? 15.22013 -3.91411  16.32292  1.000 10.30408 ? 97  ASP A CB  1 
ATOM   751  C  CG  . ASP A 1 202 ? 14.98944 -5.02306  17.33673  1.000 19.80741 ? 97  ASP A CG  1 
ATOM   752  O  OD1 . ASP A 1 202 ? 15.50393 -6.17154  17.20094  1.000 13.50947 ? 97  ASP A OD1 1 
ATOM   753  O  OD2 . ASP A 1 202 ? 14.31811 -4.72282  18.36665  1.000 20.54628 ? 97  ASP A OD2 1 
ATOM   754  N  N   . ASP A 1 203 ? 17.94948 -4.87697  15.47437  1.000 10.63736 ? 98  ASP A N   1 
ATOM   755  C  CA  . ASP A 1 203 ? 19.20247 -5.62644  15.36670  1.000 12.69580 ? 98  ASP A CA  1 
ATOM   756  C  C   . ASP A 1 203 ? 19.25219 -6.82200  16.29937  1.000 13.42261 ? 98  ASP A C   1 
ATOM   757  O  O   . ASP A 1 203 ? 20.20370 -7.61609  16.23136  1.000 13.96463 ? 98  ASP A O   1 
ATOM   758  C  CB  . ASP A 1 203 ? 20.39929 -4.69541  15.59955  1.000 11.09785 ? 98  ASP A CB  1 
ATOM   759  C  CG  . ASP A 1 203 ? 20.62385 -3.72263  14.47587  1.000 16.34423 ? 98  ASP A CG  1 
ATOM   760  O  OD1 . ASP A 1 203 ? 20.18798 -3.98978  13.32107  1.000 12.33524 ? 98  ASP A OD1 1 
ATOM   761  O  OD2 . ASP A 1 203 ? 21.26340 -2.67171  14.70962  1.000 17.03599 ? 98  ASP A OD2 1 
ATOM   762  N  N   . ASN A 1 204 ? 18.23672 -7.00318  17.12312  1.000 14.57062 ? 99  ASN A N   1 
ATOM   763  C  CA  . ASN A 1 204 ? 18.09721 -8.24825  17.84574  1.000 15.87177 ? 99  ASN A CA  1 
ATOM   764  C  C   . ASN A 1 204 ? 17.18177 -9.20660  17.12341  1.000 20.03759 ? 99  ASN A C   1 
ATOM   765  O  O   . ASN A 1 204 ? 16.90642 -10.27721 17.64412  1.000 21.01508 ? 99  ASN A O   1 
ATOM   766  C  CB  . ASN A 1 204 ? 17.54701 -7.97873  19.25067  1.000 23.96305 ? 99  ASN A CB  1 
ATOM   767  C  CG  . ASN A 1 204 ? 18.58793 -7.31880  20.12246  1.000 26.77156 ? 99  ASN A CG  1 
ATOM   768  O  OD1 . ASN A 1 204 ? 19.75678 -7.72036  20.10253  1.000 33.44401 ? 99  ASN A OD1 1 
ATOM   769  N  ND2 . ASN A 1 204 ? 18.20371 -6.23822  20.80192  1.000 30.65694 ? 99  ASN A ND2 1 
ATOM   770  N  N   . GLY A 1 205 ? 16.67109 -8.83743  15.94624  1.000 12.97977 ? 100 GLY A N   1 
ATOM   771  C  CA  . GLY A 1 205 ? 15.79072 -9.72315  15.21887  1.000 11.92453 ? 100 GLY A CA  1 
ATOM   772  C  C   . GLY A 1 205 ? 14.32998 -9.60893  15.56424  1.000 18.98118 ? 100 GLY A C   1 
ATOM   773  O  O   . GLY A 1 205 ? 13.55312 -10.47359 15.15566  1.000 21.50882 ? 100 GLY A O   1 
ATOM   774  N  N   . SER A 1 206 ? 13.93219 -8.60127  16.32841  1.000 15.01173 ? 101 SER A N   1 
ATOM   775  C  CA  . SER A 1 206 ? 12.55238 -8.47307  16.81171  1.000 16.68738 ? 101 SER A CA  1 
ATOM   776  C  C   . SER A 1 206 ? 11.86181 -7.29181  16.14613  1.000 17.82490 ? 101 SER A C   1 
ATOM   777  O  O   . SER A 1 206 ? 12.49310 -6.32676  15.71871  1.000 16.86072 ? 101 SER A O   1 
ATOM   778  C  CB  . SER A 1 206 ? 12.50600 -8.21540  18.33174  1.000 27.31283 ? 101 SER A CB  1 
ATOM   779  O  OG  . SER A 1 206 ? 13.24827 -9.16685  19.03947  1.000 40.62134 ? 101 SER A OG  1 
ATOM   780  N  N   . GLY A 1 207 ? 10.53709 -7.35027  16.09848  1.000 19.23616 ? 102 GLY A N   1 
ATOM   781  C  CA  . GLY A 1 207 ? 9.79367  -6.18359  15.65324  1.000 12.90041 ? 102 GLY A CA  1 
ATOM   782  C  C   . GLY A 1 207 ? 8.31835  -6.30043  15.98913  1.000 16.41036 ? 102 GLY A C   1 
ATOM   783  O  O   . GLY A 1 207 ? 7.79154  -7.41345  16.05975  1.000 23.01196 ? 102 GLY A O   1 
ATOM   784  N  N   . GLN A 1 208 ? 7.66317  -5.18290  16.21836  1.000 13.12979 ? 103 GLN A N   1 
ATOM   785  C  CA  . GLN A 1 208 ? 6.23369  -5.19244  16.50059  1.000 12.81006 ? 103 GLN A CA  1 
ATOM   786  C  C   . GLN A 1 208 ? 5.41516  -5.40120  15.24619  1.000 14.49789 ? 103 GLN A C   1 
ATOM   787  O  O   . GLN A 1 208 ? 5.80675  -5.01296  14.14433  1.000 13.09508 ? 103 GLN A O   1 
ATOM   788  C  CB  . GLN A 1 208 ? 5.80127  -3.88231  17.13350  1.000 21.59435 ? 103 GLN A CB  1 
ATOM   789  C  CG  . GLN A 1 208 ? 6.80893  -3.37494  18.11788  1.000 36.38023 ? 103 GLN A CG  1 
ATOM   790  C  CD  . GLN A 1 208 ? 6.10691  -2.83675  19.35231  1.000 71.44943 ? 103 GLN A CD  1 
ATOM   791  O  OE1 . GLN A 1 208 ? 5.26109  -1.92888  19.26268  1.000 64.89710 ? 103 GLN A OE1 1 
ATOM   792  N  NE2 . GLN A 1 208 ? 6.38915  -3.45058  20.50499  1.000 56.76997 ? 103 GLN A NE2 1 
ATOM   793  N  N   . TYR A 1 209 ? 4.24003  -5.98297  15.44148  1.000 12.38838 ? 104 TYR A N   1 
ATOM   794  C  CA  . TYR A 1 209 ? 3.38065  -6.25854  14.29640  1.000 10.61336 ? 104 TYR A CA  1 
ATOM   795  C  C   . TYR A 1 209 ? 3.00868  -4.98004  13.52523  1.000 9.86230  ? 104 TYR A C   1 
ATOM   796  O  O   . TYR A 1 209 ? 2.89928  -5.02527  12.28345  1.000 12.37957 ? 104 TYR A O   1 
ATOM   797  C  CB  . TYR A 1 209 ? 2.15778  -7.02055  14.78346  1.000 12.23691 ? 104 TYR A CB  1 
ATOM   798  C  CG  . TYR A 1 209 ? 2.34128  -8.54706  14.76263  1.000 19.20875 ? 104 TYR A CG  1 
ATOM   799  C  CD1 . TYR A 1 209 ? 3.41505  -9.13148  14.08393  1.000 16.04836 ? 104 TYR A CD1 1 
ATOM   800  C  CD2 . TYR A 1 209 ? 1.42715  -9.38122  15.40253  1.000 14.67043 ? 104 TYR A CD2 1 
ATOM   801  C  CE1 . TYR A 1 209 ? 3.56888  -10.55584 14.00153  1.000 20.89300 ? 104 TYR A CE1 1 
ATOM   802  C  CE2 . TYR A 1 209 ? 1.57937  -10.79314 15.36284  1.000 18.71511 ? 104 TYR A CE2 1 
ATOM   803  C  CZ  . TYR A 1 209 ? 2.65109  -11.35928 14.66485  1.000 23.90345 ? 104 TYR A CZ  1 
ATOM   804  O  OH  . TYR A 1 209 ? 2.75681  -12.73978 14.58809  1.000 23.80614 ? 104 TYR A OH  1 
ATOM   805  N  N   . SER A 1 210 ? 2.78960  -3.83504  14.21182  1.000 11.28626 ? 105 SER A N   1 
ATOM   806  C  CA  . SER A 1 210 ? 2.41410  -2.62504  13.47878  1.000 14.00675 ? 105 SER A CA  1 
ATOM   807  C  C   . SER A 1 210 ? 3.50071  -2.22946  12.48323  1.000 10.61934 ? 105 SER A C   1 
ATOM   808  O  O   . SER A 1 210 ? 3.19689  -1.70311  11.39819  1.000 11.92413 ? 105 SER A O   1 
ATOM   809  C  CB  . SER A 1 210 ? 2.12035  -1.46235  14.45686  1.000 14.31125 ? 105 SER A CB  1 
ATOM   810  O  OG  . SER A 1 210 ? 3.21577  -1.29109  15.31124  1.000 24.30327 ? 105 SER A OG  1 
ATOM   811  N  N   . THR A 1 211 ? 4.76501  -2.43164  12.84988  1.000 9.19099  ? 106 THR A N   1 
ATOM   812  C  CA  . THR A 1 211 ? 5.88389  -2.06476  11.98193  1.000 9.04559  ? 106 THR A CA  1 
ATOM   813  C  C   . THR A 1 211 ? 5.98778  -3.03260  10.81095  1.000 9.84733  ? 106 THR A C   1 
ATOM   814  O  O   . THR A 1 211 ? 6.26154  -2.63469  9.66470   1.000 10.55382 ? 106 THR A O   1 
ATOM   815  C  CB  . THR A 1 211 ? 7.17534  -2.05020  12.79109  1.000 13.46485 ? 106 THR A CB  1 
ATOM   816  O  OG1 . THR A 1 211 ? 7.03986  -1.08916  13.84511  1.000 18.39039 ? 106 THR A OG1 1 
ATOM   817  C  CG2 . THR A 1 211 ? 8.34307  -1.65248  11.90899  1.000 12.84362 ? 106 THR A CG2 1 
ATOM   818  N  N   . ILE A 1 212 ? 5.77228  -4.31596  11.07606  1.000 8.55341  ? 107 ILE A N   1 
ATOM   819  C  CA  . ILE A 1 212 ? 5.82709  -5.27889  9.98680   1.000 6.95998  ? 107 ILE A CA  1 
ATOM   820  C  C   . ILE A 1 212 ? 4.71601  -5.02069  8.97043   1.000 10.67738 ? 107 ILE A C   1 
ATOM   821  O  O   . ILE A 1 212 ? 4.93304  -5.10356  7.73923   1.000 9.88621  ? 107 ILE A O   1 
ATOM   822  C  CB  . ILE A 1 212 ? 5.77710  -6.69886  10.60111  1.000 10.29263 ? 107 ILE A CB  1 
ATOM   823  C  CG1 . ILE A 1 212 ? 7.07902  -6.96340  11.31979  1.000 11.62450 ? 107 ILE A CG1 1 
ATOM   824  C  CG2 . ILE A 1 212 ? 5.54786  -7.72478  9.53447   1.000 15.50054 ? 107 ILE A CG2 1 
ATOM   825  C  CD1 . ILE A 1 212 ? 6.93594  -8.09287  12.42196  1.000 17.53943 ? 107 ILE A CD1 1 
ATOM   826  N  N   . ILE A 1 213 ? 3.50767  -4.70164  9.45644   1.000 8.05360  ? 108 ILE A N   1 
ATOM   827  C  CA  . ILE A 1 213 ? 2.41134  -4.34032  8.55006   1.000 6.89513  ? 108 ILE A CA  1 
ATOM   828  C  C   . ILE A 1 213 ? 2.77036  -3.09569  7.74905   1.000 9.16693  ? 108 ILE A C   1 
ATOM   829  O  O   . ILE A 1 213 ? 2.60389  -3.05100  6.52835   1.000 7.98641  ? 108 ILE A O   1 
ATOM   830  C  CB  . ILE A 1 213 ? 1.13676  -4.11311  9.38307   1.000 6.99345  ? 108 ILE A CB  1 
ATOM   831  C  CG1 . ILE A 1 213 ? 0.62254  -5.47173  9.90865   1.000 9.07606  ? 108 ILE A CG1 1 
ATOM   832  C  CG2 . ILE A 1 213 ? 0.02069  -3.42701  8.52294   1.000 8.28038  ? 108 ILE A CG2 1 
ATOM   833  C  CD1 . ILE A 1 213 ? -0.46669 -5.29521  11.01782  1.000 13.33457 ? 108 ILE A CD1 1 
ATOM   834  N  N   . ALA A 1 214 ? 3.31707  -2.07139  8.40269   1.000 7.48953  ? 109 ALA A N   1 
ATOM   835  C  CA  . ALA A 1 214 ? 3.68669  -0.87345  7.63950   1.000 9.12789  ? 109 ALA A CA  1 
ATOM   836  C  C   . ALA A 1 214 ? 4.68657  -1.17256  6.54143   1.000 9.33682  ? 109 ALA A C   1 
ATOM   837  O  O   . ALA A 1 214 ? 4.59051  -0.60858  5.42164   1.000 8.46198  ? 109 ALA A O   1 
ATOM   838  C  CB  . ALA A 1 214 ? 4.23741  0.21953   8.58207   1.000 10.13369 ? 109 ALA A CB  1 
ATOM   839  N  N   . GLY A 1 215 ? 5.65182  -2.06760  6.81117   1.000 6.54537  ? 110 GLY A N   1 
ATOM   840  C  CA  . GLY A 1 215 ? 6.64263  -2.41305  5.80620   1.000 8.00250  ? 110 GLY A CA  1 
ATOM   841  C  C   . GLY A 1 215 ? 6.02757  -3.14997  4.61764   1.000 9.62145  ? 110 GLY A C   1 
ATOM   842  O  O   . GLY A 1 215 ? 6.44255  -2.92605  3.49528   1.000 8.87732  ? 110 GLY A O   1 
ATOM   843  N  N   . MET A 1 216 ? 5.00867  -3.99070  4.83816   1.000 6.85822  ? 111 MET A N   1 
ATOM   844  C  CA  . MET A 1 216 ? 4.31328  -4.65511  3.73106   1.000 6.38067  ? 111 MET A CA  1 
ATOM   845  C  C   . MET A 1 216 ? 3.55897  -3.60451  2.88758   1.000 7.90617  ? 111 MET A C   1 
ATOM   846  O  O   . MET A 1 216 ? 3.61918  -3.60883  1.64864   1.000 8.97174  ? 111 MET A O   1 
ATOM   847  C  CB  . MET A 1 216 ? 3.40935  -5.66192  4.44355   1.000 11.13653 ? 111 MET A CB  1 
ATOM   848  C  CG  . MET A 1 216 ? 4.19266  -6.91997  4.75952   1.000 8.35778  ? 111 MET A CG  1 
ATOM   849  S  SD  . MET A 1 216 ? 3.04319  -8.33552  5.00735   1.000 13.83131 ? 111 MET A SD  1 
ATOM   850  C  CE  . MET A 1 216 ? 2.98250  -8.25370  6.75460   1.000 15.07773 ? 111 MET A CE  1 
ATOM   851  N  N   . ASP A 1 217 ? 2.82587  -2.70534  3.54916   1.000 7.40505  ? 112 ASP A N   1 
ATOM   852  C  CA  . ASP A 1 217 ? 2.09930  -1.69715  2.76971   1.000 6.39459  ? 112 ASP A CA  1 
ATOM   853  C  C   . ASP A 1 217 ? 3.07643  -0.78208  2.03743   1.000 9.82659  ? 112 ASP A C   1 
ATOM   854  O  O   . ASP A 1 217 ? 2.76623  -0.30552  0.92912   1.000 8.70278  ? 112 ASP A O   1 
ATOM   855  C  CB  . ASP A 1 217 ? 1.17145  -0.86295  3.68008   1.000 9.42674  ? 112 ASP A CB  1 
ATOM   856  C  CG  . ASP A 1 217 ? -0.04938 -1.66419  4.25676   1.000 12.75069 ? 112 ASP A CG  1 
ATOM   857  O  OD1 . ASP A 1 217 ? -0.54513 -2.51733  3.53959   1.000 21.35016 ? 112 ASP A OD1 1 
ATOM   858  O  OD2 . ASP A 1 217 ? -0.44613 -1.29271  5.36483   1.000 23.08983 ? 112 ASP A OD2 1 
ATOM   859  N  N   . PHE A 1 218 ? 4.25392  -0.51277  2.63004   1.000 7.83455  ? 113 PHE A N   1 
ATOM   860  C  CA  . PHE A 1 218 ? 5.26021  0.27865   1.92529   1.000 8.37544  ? 113 PHE A CA  1 
ATOM   861  C  C   . PHE A 1 218 ? 5.68124  -0.38590  0.61849   1.000 9.42638  ? 113 PHE A C   1 
ATOM   862  O  O   . PHE A 1 218 ? 5.80951  0.28875   -0.40336  1.000 8.65707  ? 113 PHE A O   1 
ATOM   863  C  CB  . PHE A 1 218 ? 6.49151  0.47668   2.84935   1.000 8.43931  ? 113 PHE A CB  1 
ATOM   864  C  CG  . PHE A 1 218 ? 7.65639  1.08622   2.11395   1.000 8.56926  ? 113 PHE A CG  1 
ATOM   865  C  CD1 . PHE A 1 218 ? 7.70580  2.46310   1.92530   1.000 15.52496 ? 113 PHE A CD1 1 
ATOM   866  C  CD2 . PHE A 1 218 ? 8.63792  0.28720   1.56604   1.000 11.29639 ? 113 PHE A CD2 1 
ATOM   867  C  CE1 . PHE A 1 218 ? 8.79680  3.03382   1.20640   1.000 15.41818 ? 113 PHE A CE1 1 
ATOM   868  C  CE2 . PHE A 1 218 ? 9.69916  0.86073   0.82519   1.000 12.07864 ? 113 PHE A CE2 1 
ATOM   869  C  CZ  . PHE A 1 218 ? 9.74613  2.22419   0.68233   1.000 12.75953 ? 113 PHE A CZ  1 
ATOM   870  N  N   . VAL A 1 219 ? 5.97462  -1.70624  0.64097   1.000 6.77526  ? 114 VAL A N   1 
ATOM   871  C  CA  . VAL A 1 219 ? 6.40969  -2.38532  -0.60031  1.000 5.79419  ? 114 VAL A CA  1 
ATOM   872  C  C   . VAL A 1 219 ? 5.32512  -2.30633  -1.67345  1.000 6.05059  ? 114 VAL A C   1 
ATOM   873  O  O   . VAL A 1 219 ? 5.61456  -2.13705  -2.86356  1.000 8.91777  ? 114 VAL A O   1 
ATOM   874  C  CB  . VAL A 1 219 ? 6.79779  -3.85858  -0.30821  1.000 7.31387  ? 114 VAL A CB  1 
ATOM   875  C  CG1 . VAL A 1 219 ? 7.10886  -4.62137  -1.63504  1.000 9.67412  ? 114 VAL A CG1 1 
ATOM   876  C  CG2 . VAL A 1 219 ? 7.98287  -3.85993  0.61607   1.000 10.76685 ? 114 VAL A CG2 1 
ATOM   877  N  N   . ALA A 1 220 ? 4.05567  -2.47342  -1.28008  1.000 6.43236  ? 115 ALA A N   1 
ATOM   878  C  CA  . ALA A 1 220 ? 2.98527  -2.44258  -2.28640  1.000 7.72870  ? 115 ALA A CA  1 
ATOM   879  C  C   . ALA A 1 220 ? 2.94620  -1.12305  -3.02541  1.000 8.87234  ? 115 ALA A C   1 
ATOM   880  O  O   . ALA A 1 220 ? 2.61865  -1.08671  -4.21351  1.000 12.78356 ? 115 ALA A O   1 
ATOM   881  C  CB  . ALA A 1 220 ? 1.62557  -2.69088  -1.60782  1.000 9.98878  ? 115 ALA A CB  1 
ATOM   882  N  N   . SER A 1 221 ? 3.25826  -0.03138  -2.34071  1.000 8.65408  ? 116 SER A N   1 
ATOM   883  C  CA  . SER A 1 221 ? 3.34146  1.26531   -3.01000  1.000 8.05842  ? 116 SER A CA  1 
ATOM   884  C  C   . SER A 1 221 ? 4.68598  1.49366   -3.71387  1.000 11.50134 ? 116 SER A C   1 
ATOM   885  O  O   . SER A 1 221 ? 4.73316  2.04374   -4.84172  1.000 10.63309 ? 116 SER A O   1 
ATOM   886  C  CB  . SER A 1 221 ? 3.09433  2.37199   -1.96839  1.000 9.61709  ? 116 SER A CB  1 
ATOM   887  O  OG  . SER A 1 221 ? 3.21684  3.70392   -2.54664  1.000 10.75293 ? 116 SER A OG  1 
ATOM   888  N  N   . ASP A 1 222 ? 5.80142  1.18093   -3.03738  1.000 6.96537  ? 117 ASP A N   1 
ATOM   889  C  CA  . ASP A 1 222 ? 7.09815  1.55520   -3.57357  1.000 7.24247  ? 117 ASP A CA  1 
ATOM   890  C  C   . ASP A 1 222 ? 7.38257  0.87291   -4.89855  1.000 9.38758  ? 117 ASP A C   1 
ATOM   891  O  O   . ASP A 1 222 ? 8.13725  1.43345   -5.70305  1.000 11.36642 ? 117 ASP A O   1 
ATOM   892  C  CB  . ASP A 1 222 ? 8.17837  1.18694   -2.54358  1.000 9.29481  ? 117 ASP A CB  1 
ATOM   893  C  CG  . ASP A 1 222 ? 9.58602  1.60795   -2.96935  1.000 10.26232 ? 117 ASP A CG  1 
ATOM   894  O  OD1 . ASP A 1 222 ? 9.81562  2.82301   -2.92668  1.000 12.66136 ? 117 ASP A OD1 1 
ATOM   895  O  OD2 . ASP A 1 222 ? 10.36128 0.69663   -3.36468  1.000 10.84725 ? 117 ASP A OD2 1 
ATOM   896  N  N   . LYS A 1 223 ? 6.82000  -0.32534  -5.15023  1.000 8.54780  ? 118 LYS A N   1 
ATOM   897  C  CA  . LYS A 1 223 ? 7.16154  -1.05488  -6.37781  1.000 8.36063  ? 118 LYS A CA  1 
ATOM   898  C  C   . LYS A 1 223 ? 6.70643  -0.26483  -7.59528  1.000 13.60392 ? 118 LYS A C   1 
ATOM   899  O  O   . LYS A 1 223 ? 7.26671  -0.43442  -8.68986  1.000 14.92341 ? 118 LYS A O   1 
ATOM   900  C  CB  . LYS A 1 223 ? 6.51299  -2.46554  -6.37893  1.000 10.86103 ? 118 LYS A CB  1 
ATOM   901  C  CG  . LYS A 1 223 ? 4.93954  -2.34764  -6.39904  1.000 14.95854 ? 118 LYS A CG  1 
ATOM   902  C  CD  . LYS A 1 223 ? 4.33775  -3.59000  -6.83367  1.000 20.85295 ? 118 LYS A CD  1 
ATOM   903  C  CE  . LYS A 1 223 ? 2.93110  -3.49744  -7.35843  1.000 18.01234 ? 118 LYS A CE  1 
ATOM   904  N  NZ  . LYS A 1 223 ? 2.10651  -2.74560  -6.47385  1.000 19.28004 ? 118 LYS A NZ  1 
ATOM   905  N  N   . ASN A 1 224 ? 5.73127  0.63592   -7.40812  1.000 15.04773 ? 119 ASN A N   1 
ATOM   906  C  CA  . ASN A 1 224 ? 5.26378  1.45231   -8.52692  1.000 17.06087 ? 119 ASN A CA  1 
ATOM   907  C  C   . ASN A 1 224 ? 6.27871  2.53805   -8.90094  1.000 19.48935 ? 119 ASN A C   1 
ATOM   908  O  O   . ASN A 1 224 ? 6.09177  3.19997   -9.92224  1.000 27.73410 ? 119 ASN A O   1 
ATOM   909  C  CB  . ASN A 1 224 ? 3.85846  2.06709   -8.18165  1.000 15.75878 ? 119 ASN A CB  1 
ATOM   910  C  CG  . ASN A 1 224 ? 2.77454  1.02888   -7.75895  1.000 22.20876 ? 119 ASN A CG  1 
ATOM   911  O  OD1 . ASN A 1 224 ? 2.00778  1.25934   -6.79671  1.000 19.53632 ? 119 ASN A OD1 1 
ATOM   912  N  ND2 . ASN A 1 224 ? 2.66800  -0.09034  -8.49082  1.000 19.33719 ? 119 ASN A ND2 1 
ATOM   913  N  N   . ASN A 1 225 ? 7.32696  2.77167   -8.10944  1.000 16.19970 ? 120 ASN A N   1 
ATOM   914  C  CA  . ASN A 1 225 ? 8.39169  3.73748   -8.39902  1.000 19.24095 ? 120 ASN A CA  1 
ATOM   915  C  C   . ASN A 1 225 ? 9.65067  3.07411   -8.96171  1.000 21.06044 ? 120 ASN A C   1 
ATOM   916  O  O   . ASN A 1 225 ? 10.67334 3.74952   -9.13434  1.000 23.20151 ? 120 ASN A O   1 
ATOM   917  C  CB  . ASN A 1 225 ? 8.80380  4.52398   -7.14489  1.000 24.75778 ? 120 ASN A CB  1 
ATOM   918  C  CG  . ASN A 1 225 ? 7.65781  5.13671   -6.40722  1.000 31.31608 ? 120 ASN A CG  1 
ATOM   919  O  OD1 . ASN A 1 225 ? 6.56185  5.32875   -6.95326  1.000 43.55380 ? 120 ASN A OD1 1 
ATOM   920  N  ND2 . ASN A 1 225 ? 7.84255  5.25625   -5.08492  1.000 35.51212 ? 120 ASN A ND2 1 
ATOM   921  N  N   . ARG A 1 226 ? 9.62321  1.76139   -9.20385  1.000 15.35165 ? 121 ARG A N   1 
ATOM   922  C  CA  . ARG A 1 226 ? 10.84813 1.03344   -9.52670  1.000 14.82944 ? 121 ARG A CA  1 
ATOM   923  C  C   . ARG A 1 226 ? 10.69151 0.39774   -10.89036 1.000 14.02515 ? 121 ARG A C   1 
ATOM   924  O  O   . ARG A 1 226 ? 9.58580  0.03156   -11.32270 1.000 17.68526 ? 121 ARG A O   1 
ATOM   925  C  CB  . ARG A 1 226 ? 11.16334 -0.10776  -8.54125  1.000 13.69327 ? 121 ARG A CB  1 
ATOM   926  C  CG  . ARG A 1 226 ? 11.17284 0.25522   -7.04721  1.000 16.49325 ? 121 ARG A CG  1 
ATOM   927  C  CD  . ARG A 1 226 ? 12.37251 1.04059   -6.61867  1.000 16.36802 ? 121 ARG A CD  1 
ATOM   928  N  NE  . ARG A 1 226 ? 12.28010 1.56319   -5.26292  1.000 14.02054 ? 121 ARG A NE  1 
ATOM   929  C  CZ  . ARG A 1 226 ? 13.08201 2.48945   -4.78620  1.000 12.12894 ? 121 ARG A CZ  1 
ATOM   930  N  NH1 . ARG A 1 226 ? 14.13174 2.91588   -5.49290  1.000 16.61023 ? 121 ARG A NH1 1 
ATOM   931  N  NH2 . ARG A 1 226 ? 12.77229 3.08940   -3.63733  1.000 14.68877 ? 121 ARG A NH2 1 
ATOM   932  N  N   . ASN A 1 227 ? 11.81946 0.21380   -11.54869 1.000 15.99547 ? 122 ASN A N   1 
ATOM   933  C  CA  . ASN A 1 227 ? 11.81993 -0.39230  -12.87054 1.000 16.45289 ? 122 ASN A CA  1 
ATOM   934  C  C   . ASN A 1 227 ? 12.12677 -1.90573  -12.72711 1.000 14.52352 ? 122 ASN A C   1 
ATOM   935  O  O   . ASN A 1 227 ? 13.28134 -2.33002  -12.61570 1.000 16.77240 ? 122 ASN A O   1 
ATOM   936  C  CB  . ASN A 1 227 ? 12.82430 0.34854   -13.73966 1.000 21.29417 ? 122 ASN A CB  1 
ATOM   937  C  CG  . ASN A 1 227 ? 12.42807 0.32598   -15.18302 1.000 37.53931 ? 122 ASN A CG  1 
ATOM   938  O  OD1 . ASN A 1 227 ? 12.14361 -0.71970  -15.74744 1.000 34.05842 ? 122 ASN A OD1 1 
ATOM   939  N  ND2 . ASN A 1 227 ? 12.35575 1.51133   -15.78376 1.000 46.62866 ? 122 ASN A ND2 1 
ATOM   940  N  N   . CYS A 1 228 ? 11.06508 -2.71494  -12.73708 1.000 11.50811 ? 123 CYS A N   1 
ATOM   941  C  CA  . CYS A 1 228 ? 11.12087 -4.16439  -12.52469 1.000 9.78846  ? 123 CYS A CA  1 
ATOM   942  C  C   . CYS A 1 228 ? 10.28845 -4.83825  -13.61565 1.000 9.44030  ? 123 CYS A C   1 
ATOM   943  O  O   . CYS A 1 228 ? 9.18370  -5.36925  -13.38023 1.000 11.76813 ? 123 CYS A O   1 
ATOM   944  C  CB  . CYS A 1 228 ? 10.58018 -4.48838  -11.11761 1.000 12.35232 ? 123 CYS A CB  1 
ATOM   945  S  SG  . CYS A 1 228 ? 11.46608 -3.61663  -9.78413  1.000 12.45348 ? 123 CYS A SG  1 
ATOM   946  N  N   . PRO A 1 229 ? 10.78150 -4.80526  -14.85065 1.000 11.23095 ? 124 PRO A N   1 
ATOM   947  C  CA  . PRO A 1 229 ? 9.92129  -5.21343  -15.98493 1.000 14.46022 ? 124 PRO A CA  1 
ATOM   948  C  C   . PRO A 1 229 ? 9.49180  -6.66501  -15.95721 1.000 14.54102 ? 124 PRO A C   1 
ATOM   949  O  O   . PRO A 1 229 ? 8.41317  -6.99505  -16.47019 1.000 16.71523 ? 124 PRO A O   1 
ATOM   950  C  CB  . PRO A 1 229 ? 10.79389 -4.89687  -17.20402 1.000 13.49140 ? 124 PRO A CB  1 
ATOM   951  C  CG  . PRO A 1 229 ? 12.21931 -4.76210  -16.66204 1.000 15.50715 ? 124 PRO A CG  1 
ATOM   952  C  CD  . PRO A 1 229 ? 12.08618 -4.26379  -15.25175 1.000 12.18956 ? 124 PRO A CD  1 
ATOM   953  N  N   . LYS A 1 230 ? 10.25311 -7.54645  -15.31118 1.000 8.78174  ? 125 LYS A N   1 
ATOM   954  C  CA  . LYS A 1 230 ? 9.90715  -8.94676  -15.24855 1.000 9.10944  ? 125 LYS A CA  1 
ATOM   955  C  C   . LYS A 1 230 ? 9.11012  -9.28667  -13.99057 1.000 12.65022 ? 125 LYS A C   1 
ATOM   956  O  O   . LYS A 1 230 ? 8.67200  -10.42461 -13.88496 1.000 15.18998 ? 125 LYS A O   1 
ATOM   957  C  CB  . LYS A 1 230 ? 11.19977 -9.79545  -15.25454 1.000 11.60322 ? 125 LYS A CB  1 
ATOM   958  C  CG  . LYS A 1 230 ? 11.99572 -9.70926  -16.56645 1.000 13.06502 ? 125 LYS A CG  1 
ATOM   959  C  CD  . LYS A 1 230 ? 11.09901 -9.99548  -17.75251 1.000 18.04534 ? 125 LYS A CD  1 
ATOM   960  C  CE  . LYS A 1 230 ? 11.56670 -9.18107  -18.94091 1.000 48.15140 ? 125 LYS A CE  1 
ATOM   961  N  NZ  . LYS A 1 230 ? 11.42595 -9.99636  -20.17234 1.000 37.13219 ? 125 LYS A NZ  1 
ATOM   962  N  N   . GLY A 1 231 ? 8.92082  -8.34834  -13.05119 1.000 10.73190 ? 126 GLY A N   1 
ATOM   963  C  CA  . GLY A 1 231 ? 8.01595  -8.60447  -11.92836 1.000 11.64743 ? 126 GLY A CA  1 
ATOM   964  C  C   . GLY A 1 231 ? 8.69283  -8.41257  -10.58586 1.000 11.96770 ? 126 GLY A C   1 
ATOM   965  O  O   . GLY A 1 231 ? 9.89309  -8.17945  -10.49158 1.000 9.76635  ? 126 GLY A O   1 
ATOM   966  N  N   . VAL A 1 232 ? 7.87611  -8.52929  -9.53888  1.000 6.82110  ? 127 VAL A N   1 
ATOM   967  C  CA  . VAL A 1 232 ? 8.28403  -8.14593  -8.17890  1.000 6.58172  ? 127 VAL A CA  1 
ATOM   968  C  C   . VAL A 1 232 ? 7.93204  -9.27922  -7.21483  1.000 7.68305  ? 127 VAL A C   1 
ATOM   969  O  O   . VAL A 1 232 ? 6.81567  -9.81715  -7.25564  1.000 9.22531  ? 127 VAL A O   1 
ATOM   970  C  CB  . VAL A 1 232 ? 7.57099  -6.84435  -7.74739  1.000 9.35948  ? 127 VAL A CB  1 
ATOM   971  C  CG1 . VAL A 1 232 ? 8.02578  -6.40236  -6.35741  1.000 9.34725  ? 127 VAL A CG1 1 
ATOM   972  C  CG2 . VAL A 1 232 ? 7.86207  -5.73996  -8.72785  1.000 14.00125 ? 127 VAL A CG2 1 
ATOM   973  N  N   . VAL A 1 233 ? 8.88068  -9.59390  -6.31103  1.000 6.37912  ? 128 VAL A N   1 
ATOM   974  C  CA  . VAL A 1 233 ? 8.76920  -10.63088 -5.27908  1.000 6.16666  ? 128 VAL A CA  1 
ATOM   975  C  C   . VAL A 1 233 ? 9.04532  -9.97422  -3.93443  1.000 4.91474  ? 128 VAL A C   1 
ATOM   976  O  O   . VAL A 1 233 ? 9.80728  -9.01575  -3.84681  1.000 7.42281  ? 128 VAL A O   1 
ATOM   977  C  CB  . VAL A 1 233 ? 9.78653  -11.76853 -5.55144  1.000 9.09894  ? 128 VAL A CB  1 
ATOM   978  C  CG1 . VAL A 1 233 ? 9.73880  -12.88996 -4.50507  1.000 8.25327  ? 128 VAL A CG1 1 
ATOM   979  C  CG2 . VAL A 1 233 ? 9.54930  -12.35823 -6.94922  1.000 9.67720  ? 128 VAL A CG2 1 
ATOM   980  N  N   . ALA A 1 234 ? 8.41308  -10.49672 -2.87690  1.000 6.11435  ? 129 ALA A N   1 
ATOM   981  C  CA  . ALA A 1 234 ? 8.73989  -10.07584 -1.49853  1.000 5.06615  ? 129 ALA A CA  1 
ATOM   982  C  C   . ALA A 1 234 ? 8.99988  -11.33201 -0.69027  1.000 10.66113 ? 129 ALA A C   1 
ATOM   983  O  O   . ALA A 1 234 ? 8.22249  -12.28201 -0.74476  1.000 9.29908  ? 129 ALA A O   1 
ATOM   984  C  CB  . ALA A 1 234 ? 7.59367  -9.26154  -0.83713  1.000 8.05423  ? 129 ALA A CB  1 
ATOM   985  N  N   A SER A 1 235 ? 10.06447 -11.30429 0.08690   0.645 6.24032  ? 130 SER A N   1 
ATOM   986  N  N   B SER A 1 235 ? 10.10543 -11.35801 0.03297   0.355 6.30260  ? 130 SER A N   1 
ATOM   987  C  CA  A SER A 1 235 ? 10.51145 -12.46307 0.87199   0.645 6.19190  ? 130 SER A CA  1 
ATOM   988  C  CA  B SER A 1 235 ? 10.41781 -12.48041 0.91989   0.355 6.19754  ? 130 SER A CA  1 
ATOM   989  C  C   A SER A 1 235 ? 10.41682 -12.10685 2.34629   0.645 6.57294  ? 130 SER A C   1 
ATOM   990  C  C   B SER A 1 235 ? 10.30849 -12.03466 2.36962   0.355 6.66538  ? 130 SER A C   1 
ATOM   991  O  O   A SER A 1 235 ? 11.10418 -11.18828 2.79587   0.645 6.84806  ? 130 SER A O   1 
ATOM   992  O  O   B SER A 1 235 ? 10.83048 -10.97931 2.73992   0.355 6.82895  ? 130 SER A O   1 
ATOM   993  C  CB  A SER A 1 235 ? 11.94824 -12.83122 0.48773   0.645 6.66921  ? 130 SER A CB  1 
ATOM   994  C  CB  B SER A 1 235 ? 11.81199 -13.04677 0.63446   0.355 8.12325  ? 130 SER A CB  1 
ATOM   995  O  OG  A SER A 1 235 ? 12.33279 -14.10916 1.05199   0.645 4.83708  ? 130 SER A OG  1 
ATOM   996  O  OG  B SER A 1 235 ? 12.29795 -12.69102 -0.63541  0.355 18.29357 ? 130 SER A OG  1 
ATOM   997  N  N   A LEU A 1 236 ? 9.55183  -12.83750 3.11004   0.645 5.90586  ? 131 LEU A N   1 
ATOM   998  N  N   B LEU A 1 236 ? 9.63160  -12.84838 3.19653   0.355 6.02940  ? 131 LEU A N   1 
ATOM   999  C  CA  A LEU A 1 236 ? 9.30793  -12.54287 4.53925   0.645 7.08796  ? 131 LEU A CA  1 
ATOM   1000 C  CA  B LEU A 1 236 ? 9.31791  -12.46690 4.58216   0.355 7.09859  ? 131 LEU A CA  1 
ATOM   1001 C  C   A LEU A 1 236 ? 9.76184  -13.72407 5.38822   0.645 6.81495  ? 131 LEU A C   1 
ATOM   1002 C  C   B LEU A 1 236 ? 9.71280  -13.62756 5.48637   0.355 6.85472  ? 131 LEU A C   1 
ATOM   1003 O  O   A LEU A 1 236 ? 9.00130  -14.67467 5.56429   0.645 8.39743  ? 131 LEU A O   1 
ATOM   1004 O  O   B LEU A 1 236 ? 8.86936  -14.48185 5.76254   0.355 8.37730  ? 131 LEU A O   1 
ATOM   1005 C  CB  A LEU A 1 236 ? 7.82960  -12.27089 4.83436   0.645 8.27426  ? 131 LEU A CB  1 
ATOM   1006 C  CB  B LEU A 1 236 ? 7.83189  -12.13207 4.71577   0.355 8.39064  ? 131 LEU A CB  1 
ATOM   1007 C  CG  A LEU A 1 236 ? 7.29449  -10.89568 4.52371   0.645 10.82969 ? 131 LEU A CG  1 
ATOM   1008 C  CG  B LEU A 1 236 ? 7.54744  -10.72230 4.22557   0.355 8.55694  ? 131 LEU A CG  1 
ATOM   1009 C  CD1 A LEU A 1 236 ? 5.80081  -11.01729 4.31547   0.645 15.93171 ? 131 LEU A CD1 1 
ATOM   1010 C  CD1 B LEU A 1 236 ? 6.71345  -10.86150 2.99159   0.355 6.02285  ? 131 LEU A CD1 1 
ATOM   1011 C  CD2 A LEU A 1 236 ? 7.57553  -9.91137  5.66806   0.645 18.37850 ? 131 LEU A CD2 1 
ATOM   1012 C  CD2 B LEU A 1 236 ? 6.75831  -9.91175  5.29770   0.355 11.98901 ? 131 LEU A CD2 1 
ATOM   1013 N  N   . SER A 1 237 ? 10.98204 -13.65702 5.89980   1.000 7.38332  ? 132 SER A N   1 
ATOM   1014 C  CA  . SER A 1 237 ? 11.49508 -14.72171 6.77507   1.000 4.99647  ? 132 SER A CA  1 
ATOM   1015 C  C   . SER A 1 237 ? 11.28089 -14.28398 8.21224   1.000 7.49722  ? 132 SER A C   1 
ATOM   1016 O  O   . SER A 1 237 ? 12.23188 -13.99524 8.95164   1.000 11.85021 ? 132 SER A O   1 
ATOM   1017 C  CB  . SER A 1 237 ? 12.97062 -14.97280 6.50634   1.000 7.54563  ? 132 SER A CB  1 
ATOM   1018 O  OG  . SER A 1 237 ? 13.11407 -15.57164 5.22957   1.000 7.81176  ? 132 SER A OG  1 
ATOM   1019 N  N   . LEU A 1 238 ? 9.99308  -14.21121 8.59336   1.000 9.00095  ? 133 LEU A N   1 
ATOM   1020 C  CA  . LEU A 1 238 ? 9.62886  -13.72935 9.92538   1.000 8.62397  ? 133 LEU A CA  1 
ATOM   1021 C  C   . LEU A 1 238 ? 8.22661  -14.23418 10.25963  1.000 11.30804 ? 133 LEU A C   1 
ATOM   1022 O  O   . LEU A 1 238 ? 7.48741  -14.73154 9.40996   1.000 12.17738 ? 133 LEU A O   1 
ATOM   1023 C  CB  . LEU A 1 238 ? 9.71205  -12.19545 10.03827  1.000 11.23486 ? 133 LEU A CB  1 
ATOM   1024 C  CG  . LEU A 1 238 ? 8.90092  -11.42265 8.99709   1.000 11.69390 ? 133 LEU A CG  1 
ATOM   1025 C  CD1 . LEU A 1 238 ? 7.42141  -11.31245 9.36130   1.000 16.87258 ? 133 LEU A CD1 1 
ATOM   1026 C  CD2 . LEU A 1 238 ? 9.46889  -10.02971 8.94019   1.000 16.46800 ? 133 LEU A CD2 1 
ATOM   1027 N  N   . GLY A 1 239 ? 7.87668  -14.13038 11.53835  1.000 11.78438 ? 134 GLY A N   1 
ATOM   1028 C  CA  . GLY A 1 239 ? 6.50421  -14.42770 11.89129  1.000 15.18586 ? 134 GLY A CA  1 
ATOM   1029 C  C   . GLY A 1 239 ? 6.36964  -14.50751 13.39493  1.000 15.56820 ? 134 GLY A C   1 
ATOM   1030 O  O   . GLY A 1 239 ? 7.35291  -14.42960 14.14647  1.000 17.78497 ? 134 GLY A O   1 
ATOM   1031 N  N   . GLY A 1 240 ? 5.14663  -14.68112 13.81358  1.000 12.75825 ? 135 GLY A N   1 
ATOM   1032 C  CA  . GLY A 1 240 ? 4.86411  -14.84686 15.22442  1.000 11.19692 ? 135 GLY A CA  1 
ATOM   1033 C  C   . GLY A 1 240 ? 3.47253  -15.44319 15.35979  1.000 11.54161 ? 135 GLY A C   1 
ATOM   1034 O  O   . GLY A 1 240 ? 2.97772  -16.10791 14.45522  1.000 11.22229 ? 135 GLY A O   1 
ATOM   1035 N  N   . GLY A 1 241 ? 2.83509  -15.21188 16.51215  1.000 12.28691 ? 136 GLY A N   1 
ATOM   1036 C  CA  . GLY A 1 241 ? 1.53062  -15.84801 16.73031  1.000 11.23536 ? 136 GLY A CA  1 
ATOM   1037 C  C   . GLY A 1 241 ? 0.46105  -15.24909 15.83096  1.000 12.68199 ? 136 GLY A C   1 
ATOM   1038 O  O   . GLY A 1 241 ? 0.62169  -14.14956 15.27596  1.000 13.52494 ? 136 GLY A O   1 
ATOM   1039 N  N   . TYR A 1 242 ? -0.63437 -16.00137 15.67408  1.000 10.00107 ? 137 TYR A N   1 
ATOM   1040 C  CA  . TYR A 1 242 ? -1.71005 -15.63012 14.74964  1.000 7.66418  ? 137 TYR A CA  1 
ATOM   1041 C  C   . TYR A 1 242 ? -2.19409 -14.20839 14.99043  1.000 12.47818 ? 137 TYR A C   1 
ATOM   1042 O  O   . TYR A 1 242 ? -2.49123 -13.80189 16.14717  1.000 12.15636 ? 137 TYR A O   1 
ATOM   1043 C  CB  . TYR A 1 242 ? -2.91032 -16.58232 14.92236  1.000 9.90880  ? 137 TYR A CB  1 
ATOM   1044 C  CG  . TYR A 1 242 ? -4.00894 -16.24181 13.96704  1.000 7.85669  ? 137 TYR A CG  1 
ATOM   1045 C  CD1 . TYR A 1 242 ? -4.02870 -16.76376 12.69372  1.000 11.73318 ? 137 TYR A CD1 1 
ATOM   1046 C  CD2 . TYR A 1 242 ? -5.04403 -15.38288 14.36109  1.000 11.33944 ? 137 TYR A CD2 1 
ATOM   1047 C  CE1 . TYR A 1 242 ? -5.02682 -16.41387 11.78952  1.000 14.42982 ? 137 TYR A CE1 1 
ATOM   1048 C  CE2 . TYR A 1 242 ? -6.06025 -15.03383 13.47729  1.000 13.87990 ? 137 TYR A CE2 1 
ATOM   1049 C  CZ  . TYR A 1 242 ? -6.04082 -15.53618 12.20612  1.000 12.55342 ? 137 TYR A CZ  1 
ATOM   1050 O  OH  . TYR A 1 242 ? -7.06660 -15.20365 11.33015  1.000 21.20319 ? 137 TYR A OH  1 
ATOM   1051 N  N   . SER A 1 243 ? -2.31490 -13.46396 13.88578  1.000 9.86676  ? 138 SER A N   1 
ATOM   1052 C  CA  . SER A 1 243 ? -2.88481 -12.10894 13.88514  1.000 7.72741  ? 138 SER A CA  1 
ATOM   1053 C  C   . SER A 1 243 ? -3.62720 -11.90116 12.58438  1.000 12.47297 ? 138 SER A C   1 
ATOM   1054 O  O   . SER A 1 243 ? -3.04687 -12.00842 11.49629  1.000 12.36599 ? 138 SER A O   1 
ATOM   1055 C  CB  . SER A 1 243 ? -1.78950 -11.03748 14.00383  1.000 12.97594 ? 138 SER A CB  1 
ATOM   1056 O  OG  . SER A 1 243 ? -2.30010 -9.72677  13.59614  1.000 13.65708 ? 138 SER A OG  1 
ATOM   1057 N  N   A SER A 1 244 ? -4.93674 -11.66468 12.66778  0.623 12.09904 ? 139 SER A N   1 
ATOM   1058 N  N   B SER A 1 244 ? -4.89409 -11.50977 12.69965  0.377 12.00040 ? 139 SER A N   1 
ATOM   1059 C  CA  A SER A 1 244 ? -5.67341 -11.50900 11.42911  0.623 11.40762 ? 139 SER A CA  1 
ATOM   1060 C  CA  B SER A 1 244 ? -5.65737 -11.27231 11.49291  0.377 11.55349 ? 139 SER A CA  1 
ATOM   1061 C  C   A SER A 1 244 ? -5.21295 -10.25609 10.68325  0.623 11.47163 ? 139 SER A C   1 
ATOM   1062 C  C   B SER A 1 244 ? -5.15746 -10.02123 10.76620  0.377 10.60623 ? 139 SER A C   1 
ATOM   1063 O  O   A SER A 1 244 ? -5.26408 -10.22383 9.44719   0.623 13.30966 ? 139 SER A O   1 
ATOM   1064 O  O   B SER A 1 244 ? -5.18873 -9.97746  9.53258   0.377 12.94693 ? 139 SER A O   1 
ATOM   1065 C  CB  A SER A 1 244 ? -7.17055 -11.47604 11.72148  0.623 13.71744 ? 139 SER A CB  1 
ATOM   1066 C  CB  B SER A 1 244 ? -7.14346 -11.19064 11.83921  0.377 13.89804 ? 139 SER A CB  1 
ATOM   1067 O  OG  A SER A 1 244 ? -7.45487 -10.34513 12.51997  0.623 13.31378 ? 139 SER A OG  1 
ATOM   1068 O  OG  B SER A 1 244 ? -7.91512 -10.94792 10.68561  0.377 14.71289 ? 139 SER A OG  1 
ATOM   1069 N  N   A SER A 1 245 ? -4.71540 -9.25123  11.40945  0.623 9.93816  ? 140 SER A N   1 
ATOM   1070 N  N   B SER A 1 245 ? -4.64964 -9.02508  11.49473  0.377 10.90860 ? 140 SER A N   1 
ATOM   1071 C  CA  A SER A 1 245 ? -4.26890 -8.01977  10.74828  0.623 10.06636 ? 140 SER A CA  1 
ATOM   1072 C  CA  B SER A 1 245 ? -4.16858 -7.81448  10.82439  0.377 9.84450  ? 140 SER A CA  1 
ATOM   1073 C  C   A SER A 1 245 ? -2.98824 -8.26243  9.95721   0.623 8.52929  ? 140 SER A C   1 
ATOM   1074 C  C   B SER A 1 245 ? -2.82682 -8.02116  10.12182  0.377 8.76263  ? 140 SER A C   1 
ATOM   1075 O  O   A SER A 1 245 ? -2.83485 -7.75166  8.84261   0.623 8.61060  ? 140 SER A O   1 
ATOM   1076 O  O   B SER A 1 245 ? -2.50904 -7.28841  9.17683   0.377 9.98053  ? 140 SER A O   1 
ATOM   1077 C  CB  A SER A 1 245 ? -4.01559 -6.90296  11.75767  0.623 11.48309 ? 140 SER A CB  1 
ATOM   1078 C  CB  B SER A 1 245 ? -4.05225 -6.65310  11.81020  0.377 11.61161 ? 140 SER A CB  1 
ATOM   1079 O  OG  A SER A 1 245 ? -5.18387 -6.55517  12.45700  0.623 21.47790 ? 140 SER A OG  1 
ATOM   1080 O  OG  B SER A 1 245 ? -3.27251 -7.04116  12.92672  0.377 12.60473 ? 140 SER A OG  1 
ATOM   1081 N  N   . VAL A 1 246 ? -2.04100 -9.01800  10.53640  1.000 8.77506  ? 141 VAL A N   1 
ATOM   1082 C  CA  . VAL A 1 246 ? -0.80445 -9.32362  9.81634   1.000 7.71381  ? 141 VAL A CA  1 
ATOM   1083 C  C   . VAL A 1 246 ? -1.14136 -10.15596 8.59813   1.000 7.92845  ? 141 VAL A C   1 
ATOM   1084 O  O   . VAL A 1 246 ? -0.60163 -9.93928  7.50606   1.000 9.52520  ? 141 VAL A O   1 
ATOM   1085 C  CB  . VAL A 1 246 ? 0.19398  -10.05400 10.74671  1.000 9.98898  ? 141 VAL A CB  1 
ATOM   1086 C  CG1 . VAL A 1 246 ? 1.37424  -10.57017 9.92525   1.000 11.56575 ? 141 VAL A CG1 1 
ATOM   1087 C  CG2 . VAL A 1 246 ? 0.66659  -9.10036  11.79773  1.000 11.16752 ? 141 VAL A CG2 1 
ATOM   1088 N  N   . ASN A 1 247 ? -2.07789 -11.09627 8.73543   1.000 7.77404  ? 142 ASN A N   1 
ATOM   1089 C  CA  . ASN A 1 247 ? -2.46173 -11.88835 7.56786   1.000 8.64074  ? 142 ASN A CA  1 
ATOM   1090 C  C   . ASN A 1 247 ? -3.06266 -10.99952 6.49956   1.000 9.25729  ? 142 ASN A C   1 
ATOM   1091 O  O   . ASN A 1 247 ? -2.78476 -11.17382 5.28747   1.000 8.98189  ? 142 ASN A O   1 
ATOM   1092 C  CB  . ASN A 1 247 ? -3.46602 -12.97897 7.92693   1.000 9.03905  ? 142 ASN A CB  1 
ATOM   1093 C  CG  . ASN A 1 247 ? -2.81771 -14.17298 8.58892   1.000 9.94130  ? 142 ASN A CG  1 
ATOM   1094 O  OD1 . ASN A 1 247 ? -1.65299 -14.14585 8.98157   1.000 10.63560 ? 142 ASN A OD1 1 
ATOM   1095 N  ND2 . ASN A 1 247 ? -3.61395 -15.24310 8.73117   1.000 10.88407 ? 142 ASN A ND2 1 
ATOM   1096 N  N   A SER A 1 248 ? -3.86106 -10.02291 6.92292   0.583 8.94377  ? 143 SER A N   1 
ATOM   1097 N  N   B SER A 1 248 ? -3.90308 -10.04401 6.90023   0.417 8.98230  ? 143 SER A N   1 
ATOM   1098 C  CA  A SER A 1 248 ? -4.53866 -9.17983  5.95127   0.583 8.77184  ? 143 SER A CA  1 
ATOM   1099 C  CA  B SER A 1 248 ? -4.53024 -9.18526  5.89827   0.417 8.78043  ? 143 SER A CA  1 
ATOM   1100 C  C   A SER A 1 248 ? -3.53110 -8.31272  5.20807   0.583 9.73485  ? 143 SER A C   1 
ATOM   1101 C  C   B SER A 1 248 ? -3.49271 -8.34090  5.17693   0.417 9.74525  ? 143 SER A C   1 
ATOM   1102 O  O   A SER A 1 248 ? -3.69028 -8.07655  3.99313   0.583 10.47290 ? 143 SER A O   1 
ATOM   1103 O  O   B SER A 1 248 ? -3.60295 -8.11847  3.95885   0.417 10.45658 ? 143 SER A O   1 
ATOM   1104 C  CB  A SER A 1 248 ? -5.59834 -8.32230  6.65769   0.583 11.61312 ? 143 SER A CB  1 
ATOM   1105 C  CB  B SER A 1 248 ? -5.60248 -8.29239  6.53045   0.417 11.60986 ? 143 SER A CB  1 
ATOM   1106 O  OG  A SER A 1 248 ? -6.20585 -7.43213  5.74967   0.583 15.35351 ? 143 SER A OG  1 
ATOM   1107 O  OG  B SER A 1 248 ? -6.64812 -9.07761  7.04599   0.417 15.64746 ? 143 SER A OG  1 
ATOM   1108 N  N   . ALA A 1 249 ? -2.47142 -7.86799  5.89770   1.000 6.92186  ? 144 ALA A N   1 
ATOM   1109 C  CA  . ALA A 1 249 ? -1.42825 -7.11610  5.22492   1.000 7.71200  ? 144 ALA A CA  1 
ATOM   1110 C  C   . ALA A 1 249 ? -0.69246 -7.96128  4.18628   1.000 9.94970  ? 144 ALA A C   1 
ATOM   1111 O  O   . ALA A 1 249 ? -0.37686 -7.46544  3.09422   1.000 7.44569  ? 144 ALA A O   1 
ATOM   1112 C  CB  . ALA A 1 249 ? -0.44184 -6.53003  6.25719   1.000 10.83042 ? 144 ALA A CB  1 
ATOM   1113 N  N   . ALA A 1 250 ? -0.44873 -9.24745  4.48135   1.000 7.70489  ? 145 ALA A N   1 
ATOM   1114 C  CA  . ALA A 1 250 ? 0.21662  -10.07495 3.47579   1.000 5.83970  ? 145 ALA A CA  1 
ATOM   1115 C  C   . ALA A 1 250 ? -0.68322 -10.30187 2.26724   1.000 7.05043  ? 145 ALA A C   1 
ATOM   1116 O  O   . ALA A 1 250 ? -0.20590 -10.31524 1.13670   1.000 6.73839  ? 145 ALA A O   1 
ATOM   1117 C  CB  . ALA A 1 250 ? 0.62888  -11.40614 4.15092   1.000 7.61611  ? 145 ALA A CB  1 
ATOM   1118 N  N   . ALA A 1 251 ? -1.97911 -10.55021 2.50961   1.000 6.63642  ? 146 ALA A N   1 
ATOM   1119 C  CA  . ALA A 1 251 ? -2.95056 -10.70069 1.43460   1.000 8.65746  ? 146 ALA A CA  1 
ATOM   1120 C  C   . ALA A 1 251 ? -3.02286 -9.45394  0.54895   1.000 7.16451  ? 146 ALA A C   1 
ATOM   1121 O  O   . ALA A 1 251 ? -3.11785 -9.57769  -0.69022  1.000 9.58403  ? 146 ALA A O   1 
ATOM   1122 C  CB  . ALA A 1 251 ? -4.32830 -11.01883 2.04183   1.000 8.16093  ? 146 ALA A CB  1 
ATOM   1123 N  N   . ARG A 1 252 ? -2.97450 -8.25194  1.16658   1.000 7.53313  ? 147 ARG A N   1 
ATOM   1124 C  CA  . ARG A 1 252 ? -2.96812 -7.01156  0.39326   1.000 7.22387  ? 147 ARG A CA  1 
ATOM   1125 C  C   . ARG A 1 252 ? -1.74031 -6.93626  -0.48975  1.000 8.60414  ? 147 ARG A C   1 
ATOM   1126 O  O   . ARG A 1 252 ? -1.83628 -6.54815  -1.66162  1.000 8.85787  ? 147 ARG A O   1 
ATOM   1127 C  CB  . ARG A 1 252 ? -2.96009 -5.77619  1.32641   1.000 10.87905 ? 147 ARG A CB  1 
ATOM   1128 C  CG  . ARG A 1 252 ? -4.27411 -5.50847  1.97309   1.000 13.70511 ? 147 ARG A CG  1 
ATOM   1129 C  CD  . ARG A 1 252 ? -4.25038 -4.01660  2.46598   1.000 11.20128 ? 147 ARG A CD  1 
ATOM   1130 N  NE  . ARG A 1 252 ? -3.23689 -3.76936  3.50288   1.000 11.17445 ? 147 ARG A NE  1 
ATOM   1131 C  CZ  . ARG A 1 252 ? -3.39909 -4.04976  4.79507   1.000 11.76767 ? 147 ARG A CZ  1 
ATOM   1132 N  NH1 . ARG A 1 252 ? -4.47705 -4.67500  5.24908   1.000 10.64220 ? 147 ARG A NH1 1 
ATOM   1133 N  NH2 . ARG A 1 252 ? -2.45752 -3.65961  5.67744   1.000 10.45768 ? 147 ARG A NH2 1 
ATOM   1134 N  N   . LEU A 1 253 ? -0.55592 -7.25482  0.07691   1.000 6.59062  ? 148 LEU A N   1 
ATOM   1135 C  CA  . LEU A 1 253 ? 0.65980  -7.18636  -0.72772  1.000 5.77975  ? 148 LEU A CA  1 
ATOM   1136 C  C   . LEU A 1 253 ? 0.59585  -8.11683  -1.94152  1.000 6.29610  ? 148 LEU A C   1 
ATOM   1137 O  O   . LEU A 1 253 ? 0.88904  -7.70693  -3.08072  1.000 8.25064  ? 148 LEU A O   1 
ATOM   1138 C  CB  . LEU A 1 253 ? 1.85116  -7.47662  0.21369   1.000 7.69292  ? 148 LEU A CB  1 
ATOM   1139 C  CG  . LEU A 1 253 ? 3.23740  -7.39160  -0.44244  1.000 8.92543  ? 148 LEU A CG  1 
ATOM   1140 C  CD1 . LEU A 1 253 ? 3.52108  -6.02642  -1.12850  1.000 10.17199 ? 148 LEU A CD1 1 
ATOM   1141 C  CD2 . LEU A 1 253 ? 4.31877  -7.74323  0.58323   1.000 10.24966 ? 148 LEU A CD2 1 
ATOM   1142 N  N   . GLN A 1 254 ? 0.10196  -9.32301  -1.73686  1.000 7.12528  ? 149 GLN A N   1 
ATOM   1143 C  CA  . GLN A 1 254 ? -0.05948 -10.27693 -2.82769  1.000 6.07785  ? 149 GLN A CA  1 
ATOM   1144 C  C   . GLN A 1 254 ? -1.05776 -9.75731  -3.87015  1.000 8.93191  ? 149 GLN A C   1 
ATOM   1145 O  O   . GLN A 1 254 ? -0.78400 -9.77216  -5.08192  1.000 8.40550  ? 149 GLN A O   1 
ATOM   1146 C  CB  . GLN A 1 254 ? -0.50308 -11.63563 -2.21496  1.000 6.53819  ? 149 GLN A CB  1 
ATOM   1147 C  CG  . GLN A 1 254 ? -0.81314 -12.70385 -3.27548  1.000 7.78817  ? 149 GLN A CG  1 
ATOM   1148 C  CD  . GLN A 1 254 ? 0.45201  -13.24109 -3.92448  1.000 8.57623  ? 149 GLN A CD  1 
ATOM   1149 O  OE1 . GLN A 1 254 ? 1.45214  -13.51570 -3.27553  1.000 8.02332  ? 149 GLN A OE1 1 
ATOM   1150 N  NE2 . GLN A 1 254 ? 0.39196  -13.39900 -5.22603  1.000 14.61244 ? 149 GLN A NE2 1 
ATOM   1151 N  N   A SER A 1 255 ? -2.19089 -9.23019  -3.40114  0.513 8.33376  ? 150 SER A N   1 
ATOM   1152 N  N   B SER A 1 255 ? -2.19793 -9.24848  -3.42939  0.487 8.34946  ? 150 SER A N   1 
ATOM   1153 C  CA  A SER A 1 255 ? -3.21515 -8.69379  -4.30070  0.513 7.41922  ? 150 SER A CA  1 
ATOM   1154 C  CA  B SER A 1 255 ? -3.16036 -8.78550  -4.42737  0.487 7.36301  ? 150 SER A CA  1 
ATOM   1155 C  C   A SER A 1 255 ? -2.68888 -7.53918  -5.14735  0.513 9.04062  ? 150 SER A C   1 
ATOM   1156 C  C   B SER A 1 255 ? -2.68288 -7.53654  -5.17696  0.487 9.05376  ? 150 SER A C   1 
ATOM   1157 O  O   A SER A 1 255 ? -3.13282 -7.35849  -6.30369  0.513 11.22331 ? 150 SER A O   1 
ATOM   1158 O  O   B SER A 1 255 ? -3.15617 -7.29410  -6.30798  0.487 11.21706 ? 150 SER A O   1 
ATOM   1159 C  CB  A SER A 1 255 ? -4.43307 -8.27103  -3.45938  0.513 8.11540  ? 150 SER A CB  1 
ATOM   1160 C  CB  B SER A 1 255 ? -4.51028 -8.55935  -3.74358  0.487 9.65104  ? 150 SER A CB  1 
ATOM   1161 O  OG  A SER A 1 255 ? -5.32769 -7.36797  -4.13752  0.513 10.45525 ? 150 SER A OG  1 
ATOM   1162 O  OG  B SER A 1 255 ? -4.45524 -7.39146  -2.96814  0.487 11.41776 ? 150 SER A OG  1 
ATOM   1163 N  N   . SER A 1 256 ? -1.75133 -6.75471  -4.60318  1.000 7.45722  ? 151 SER A N   1 
ATOM   1164 C  CA  . SER A 1 256 ? -1.20223 -5.59292  -5.31764  1.000 6.64290  ? 151 SER A CA  1 
ATOM   1165 C  C   . SER A 1 256 ? -0.32508 -5.96938  -6.51027  1.000 10.26384 ? 151 SER A C   1 
ATOM   1166 O  O   . SER A 1 256 ? 0.11610  -5.06329  -7.24198  1.000 12.37310 ? 151 SER A O   1 
ATOM   1167 C  CB  . SER A 1 256 ? -0.43322 -4.73443  -4.33822  1.000 8.03359  ? 151 SER A CB  1 
ATOM   1168 O  OG  . SER A 1 256 ? 0.90963  -5.18242  -4.19413  1.000 9.84921  ? 151 SER A OG  1 
ATOM   1169 N  N   . GLY A 1 257 ? 0.00653  -7.24349  -6.66150  1.000 8.23125  ? 152 GLY A N   1 
ATOM   1170 C  CA  . GLY A 1 257 ? 0.78034  -7.75484  -7.78481  1.000 9.25953  ? 152 GLY A CA  1 
ATOM   1171 C  C   . GLY A 1 257 ? 2.20590  -8.18908  -7.43527  1.000 10.07507 ? 152 GLY A C   1 
ATOM   1172 O  O   . GLY A 1 257 ? 3.08830  -8.09869  -8.30120  1.000 15.27256 ? 152 GLY A O   1 
ATOM   1173 N  N   . VAL A 1 258 ? 2.46373  -8.53885  -6.18333  1.000 8.53404  ? 153 VAL A N   1 
ATOM   1174 C  CA  . VAL A 1 258 ? 3.79537  -8.94255  -5.72229  1.000 6.10311  ? 153 VAL A CA  1 
ATOM   1175 C  C   . VAL A 1 258 ? 3.68165  -10.40419 -5.32606  1.000 9.57660  ? 153 VAL A C   1 
ATOM   1176 O  O   . VAL A 1 258 ? 2.74291  -10.78060 -4.61039  1.000 9.16004  ? 153 VAL A O   1 
ATOM   1177 C  CB  . VAL A 1 258 ? 4.17172  -8.06713  -4.51469  1.000 6.77429  ? 153 VAL A CB  1 
ATOM   1178 C  CG1 . VAL A 1 258 ? 5.50874  -8.55415  -3.92437  1.000 9.58575  ? 153 VAL A CG1 1 
ATOM   1179 C  CG2 . VAL A 1 258 ? 4.38143  -6.57116  -4.87129  1.000 9.78347  ? 153 VAL A CG2 1 
ATOM   1180 N  N   . MET A 1 259 ? 4.66088  -11.23957 -5.72117  1.000 5.58687  ? 154 MET A N   1 
ATOM   1181 C  CA  . MET A 1 259 ? 4.71548  -12.61132 -5.27979  1.000 6.33506  ? 154 MET A CA  1 
ATOM   1182 C  C   . MET A 1 259 ? 5.20353  -12.62272 -3.84772  1.000 7.82300  ? 154 MET A C   1 
ATOM   1183 O  O   . MET A 1 259 ? 6.34816  -12.27453 -3.62489  1.000 6.95528  ? 154 MET A O   1 
ATOM   1184 C  CB  . MET A 1 259 ? 5.68567  -13.40743 -6.15177  1.000 7.74865  ? 154 MET A CB  1 
ATOM   1185 C  CG  . MET A 1 259 ? 5.40442  -14.88102 -6.00258  1.000 14.36059 ? 154 MET A CG  1 
ATOM   1186 S  SD  . MET A 1 259 ? 6.48741  -15.50278 -4.60098  1.000 12.48748 ? 154 MET A SD  1 
ATOM   1187 C  CE  . MET A 1 259 ? 6.12719  -17.30760 -4.77808  1.000 13.19768 ? 154 MET A CE  1 
ATOM   1188 N  N   . VAL A 1 260 ? 4.36563  -13.00855 -2.88495  1.000 6.53225  ? 155 VAL A N   1 
ATOM   1189 C  CA  . VAL A 1 260 ? 4.77109  -12.99471 -1.47453  1.000 4.18993  ? 155 VAL A CA  1 
ATOM   1190 C  C   . VAL A 1 260 ? 5.13328  -14.40537 -1.05071  1.000 7.13366  ? 155 VAL A C   1 
ATOM   1191 O  O   . VAL A 1 260 ? 4.28740  -15.31442 -1.11641  1.000 7.89003  ? 155 VAL A O   1 
ATOM   1192 C  CB  . VAL A 1 260 ? 3.64650  -12.44379 -0.60383  1.000 4.84456  ? 155 VAL A CB  1 
ATOM   1193 C  CG1 . VAL A 1 260 ? 4.06085  -12.43918 0.86259   1.000 8.78262  ? 155 VAL A CG1 1 
ATOM   1194 C  CG2 . VAL A 1 260 ? 3.29418  -11.04256 -1.06420  1.000 7.80430  ? 155 VAL A CG2 1 
ATOM   1195 N  N   . ALA A 1 261 ? 6.37125  -14.59097 -0.55436  1.000 5.32238  ? 156 ALA A N   1 
ATOM   1196 C  CA  . ALA A 1 261 ? 6.78701  -15.87170 0.03719   1.000 4.60739  ? 156 ALA A CA  1 
ATOM   1197 C  C   . ALA A 1 261 ? 7.04590  -15.64997 1.51772   1.000 5.97131  ? 156 ALA A C   1 
ATOM   1198 O  O   . ALA A 1 261 ? 7.73361  -14.68374 1.88074   1.000 7.24060  ? 156 ALA A O   1 
ATOM   1199 C  CB  . ALA A 1 261 ? 8.08905  -16.34333 -0.62729  1.000 9.46286  ? 156 ALA A CB  1 
ATOM   1200 N  N   A VAL A 1 262 ? 6.48090  -16.51895 2.38284   0.787 5.01263  ? 157 VAL A N   1 
ATOM   1201 N  N   B VAL A 1 262 ? 6.57510  -16.57257 2.35433   0.213 5.08626  ? 157 VAL A N   1 
ATOM   1202 C  CA  A VAL A 1 262 ? 6.64989  -16.33293 3.83076   0.787 6.41457  ? 157 VAL A CA  1 
ATOM   1203 C  CA  B VAL A 1 262 ? 6.61817  -16.37664 3.79680   0.213 6.42486  ? 157 VAL A CA  1 
ATOM   1204 C  C   A VAL A 1 262 ? 7.10841  -17.62600 4.48361   0.787 6.33122  ? 157 VAL A C   1 
ATOM   1205 C  C   B VAL A 1 262 ? 7.16239  -17.63867 4.45509   0.213 6.33364  ? 157 VAL A C   1 
ATOM   1206 O  O   A VAL A 1 262 ? 6.75203  -18.73134 4.06319   0.787 6.51688  ? 157 VAL A O   1 
ATOM   1207 O  O   B VAL A 1 262 ? 6.95948  -18.75072 3.95594   0.213 6.44527  ? 157 VAL A O   1 
ATOM   1208 C  CB  A VAL A 1 262 ? 5.38938  -15.82551 4.57176   0.787 7.18504  ? 157 VAL A CB  1 
ATOM   1209 C  CB  B VAL A 1 262 ? 5.21652  -16.03283 4.33691   0.213 7.29642  ? 157 VAL A CB  1 
ATOM   1210 C  CG1 A VAL A 1 262 ? 4.83272  -14.60957 3.86662   0.787 9.00890  ? 157 VAL A CG1 1 
ATOM   1211 C  CG1 B VAL A 1 262 ? 5.26597  -15.83055 5.81170   0.213 6.91131  ? 157 VAL A CG1 1 
ATOM   1212 C  CG2 A VAL A 1 262 ? 4.32966  -16.92181 4.63815   0.787 9.87237  ? 157 VAL A CG2 1 
ATOM   1213 C  CG2 B VAL A 1 262 ? 4.64127  -14.81805 3.60812   0.213 8.16586  ? 157 VAL A CG2 1 
ATOM   1214 N  N   . ALA A 1 263 ? 7.85645  -17.47549 5.59261   1.000 5.69803  ? 158 ALA A N   1 
ATOM   1215 C  CA  . ALA A 1 263 ? 8.33628  -18.66693 6.31270   1.000 4.86024  ? 158 ALA A CA  1 
ATOM   1216 C  C   . ALA A 1 263 ? 7.22845  -19.36412 7.07823   1.000 6.54129  ? 158 ALA A C   1 
ATOM   1217 O  O   . ALA A 1 263 ? 6.36806  -18.71166 7.68233   1.000 9.06940  ? 158 ALA A O   1 
ATOM   1218 C  CB  . ALA A 1 263 ? 9.43929  -18.28619 7.28352   1.000 6.93558  ? 158 ALA A CB  1 
ATOM   1219 N  N   . ALA A 1 264 ? 7.25983  -20.72827 7.06639   1.000 5.66024  ? 159 ALA A N   1 
ATOM   1220 C  CA  . ALA A 1 264 ? 6.21197  -21.41851 7.82609   1.000 7.09985  ? 159 ALA A CA  1 
ATOM   1221 C  C   . ALA A 1 264 ? 6.38454  -21.29857 9.35034   1.000 8.66340  ? 159 ALA A C   1 
ATOM   1222 O  O   . ALA A 1 264 ? 5.39438  -21.44213 10.08587  1.000 10.56372 ? 159 ALA A O   1 
ATOM   1223 C  CB  . ALA A 1 264 ? 6.17706  -22.90781 7.48634   1.000 8.61426  ? 159 ALA A CB  1 
ATOM   1224 N  N   . GLY A 1 265 ? 7.60828  -21.11081 9.84656   1.000 7.50459  ? 160 GLY A N   1 
ATOM   1225 C  CA  . GLY A 1 265 ? 7.91903  -21.04579 11.25966  1.000 8.11630  ? 160 GLY A CA  1 
ATOM   1226 C  C   . GLY A 1 265 ? 8.63878  -22.29759 11.73983  1.000 7.73934  ? 160 GLY A C   1 
ATOM   1227 O  O   . GLY A 1 265 ? 8.63978  -23.34788 11.07346  1.000 7.89985  ? 160 GLY A O   1 
ATOM   1228 N  N   . ASN A 1 266 ? 9.28050  -22.16820 12.93580  1.000 8.94531  ? 161 ASN A N   1 
ATOM   1229 C  CA  . ASN A 1 266 ? 10.27273 -23.14746 13.40678  1.000 8.20909  ? 161 ASN A CA  1 
ATOM   1230 C  C   . ASN A 1 266 ? 9.84813  -23.82087 14.70488  1.000 11.26688 ? 161 ASN A C   1 
ATOM   1231 O  O   . ASN A 1 266 ? 10.70655 -24.11106 15.55598  1.000 14.65376 ? 161 ASN A O   1 
ATOM   1232 C  CB  . ASN A 1 266 ? 11.62869 -22.47560 13.62482  1.000 8.94110  ? 161 ASN A CB  1 
ATOM   1233 C  CG  . ASN A 1 266 ? 12.16687 -21.79649 12.36492  1.000 18.11236 ? 161 ASN A CG  1 
ATOM   1234 O  OD1 . ASN A 1 266 ? 11.95141 -22.25635 11.24349  1.000 14.91082 ? 161 ASN A OD1 1 
ATOM   1235 N  ND2 . ASN A 1 266 ? 12.75141 -20.62311 12.54113  1.000 31.47863 ? 161 ASN A ND2 1 
ATOM   1236 N  N   . ASN A 1 267 ? 8.54719  -24.09263 14.87899  1.000 8.92616  ? 162 ASN A N   1 
ATOM   1237 C  CA  . ASN A 1 267 ? 8.02597  -24.63459 16.15905  1.000 8.91860  ? 162 ASN A CA  1 
ATOM   1238 C  C   . ASN A 1 267 ? 7.65245  -26.11234 16.08705  1.000 15.53768 ? 162 ASN A C   1 
ATOM   1239 O  O   . ASN A 1 267 ? 7.03908  -26.64457 17.04696  1.000 12.51387 ? 162 ASN A O   1 
ATOM   1240 C  CB  . ASN A 1 267 ? 6.77274  -23.85602 16.57044  1.000 15.47655 ? 162 ASN A CB  1 
ATOM   1241 C  CG  . ASN A 1 267 ? 6.91097  -22.35552 16.30008  1.000 36.19799 ? 162 ASN A CG  1 
ATOM   1242 O  OD1 . ASN A 1 267 ? 6.47966  -21.81451 15.24240  1.000 25.13900 ? 162 ASN A OD1 1 
ATOM   1243 N  ND2 . ASN A 1 267 ? 7.52590  -21.67694 17.24632  1.000 24.76061 ? 162 ASN A ND2 1 
ATOM   1244 N  N   . ASN A 1 268 ? 7.93885  -26.78094 14.97262  1.000 11.05453 ? 163 ASN A N   1 
ATOM   1245 C  CA  . ASN A 1 268 ? 7.51431  -28.16633 14.74281  1.000 9.98477  ? 163 ASN A CA  1 
ATOM   1246 C  C   . ASN A 1 268 ? 6.03256  -28.34212 15.06834  1.000 11.51903 ? 163 ASN A C   1 
ATOM   1247 O  O   . ASN A 1 268 ? 5.61207  -29.25670 15.80757  1.000 12.91467 ? 163 ASN A O   1 
ATOM   1248 C  CB  . ASN A 1 268 ? 8.39577  -29.11799 15.55839  1.000 9.57389  ? 163 ASN A CB  1 
ATOM   1249 C  CG  . ASN A 1 268 ? 8.14894  -30.57648 15.25606  1.000 11.89901 ? 163 ASN A CG  1 
ATOM   1250 O  OD1 . ASN A 1 268 ? 7.84095  -30.96943 14.15810  1.000 12.17794 ? 163 ASN A OD1 1 
ATOM   1251 N  ND2 . ASN A 1 268 ? 8.21859  -31.42558 16.34130  1.000 14.81741 ? 163 ASN A ND2 1 
ATOM   1252 N  N   . ALA A 1 269 ? 5.22709  -27.39286 14.56591  1.000 9.18369  ? 164 ALA A N   1 
ATOM   1253 C  CA  . ALA A 1 269 ? 3.80557  -27.35950 14.90017  1.000 11.29931 ? 164 ALA A CA  1 
ATOM   1254 C  C   . ALA A 1 269 ? 3.01910  -27.01840 13.64314  1.000 12.25779 ? 164 ALA A C   1 
ATOM   1255 O  O   . ALA A 1 269 ? 3.58908  -26.76691 12.57794  1.000 11.45567 ? 164 ALA A O   1 
ATOM   1256 C  CB  . ALA A 1 269 ? 3.55242  -26.31122 15.98485  1.000 14.76272 ? 164 ALA A CB  1 
ATOM   1257 N  N   . ASP A 1 270 ? 1.68671  -27.01769 13.76830  1.000 12.33872 ? 165 ASP A N   1 
ATOM   1258 C  CA  . ASP A 1 270 ? 0.83548  -26.64209 12.64788  1.000 10.48828 ? 165 ASP A CA  1 
ATOM   1259 C  C   . ASP A 1 270 ? 0.90368  -25.13822 12.43781  1.000 10.22791 ? 165 ASP A C   1 
ATOM   1260 O  O   . ASP A 1 270 ? 0.68121  -24.34282 13.36993  1.000 11.00254 ? 165 ASP A O   1 
ATOM   1261 C  CB  . ASP A 1 270 ? -0.61248 -27.06824 12.90447  1.000 13.75862 ? 165 ASP A CB  1 
ATOM   1262 C  CG  . ASP A 1 270 ? -1.45101 -27.07646 11.62321  1.000 18.70929 ? 165 ASP A CG  1 
ATOM   1263 O  OD1 . ASP A 1 270 ? -1.46858 -26.04768 10.92378  1.000 15.74727 ? 165 ASP A OD1 1 
ATOM   1264 O  OD2 . ASP A 1 270 ? -2.14618 -28.08508 11.31034  1.000 23.38008 ? 165 ASP A OD2 1 
ATOM   1265 N  N   . ALA A 1 271 ? 1.26551  -24.75510 11.20831  1.000 9.63797  ? 166 ALA A N   1 
ATOM   1266 C  CA  . ALA A 1 271 ? 1.44528  -23.36109 10.87194  1.000 10.34622 ? 166 ALA A CA  1 
ATOM   1267 C  C   . ALA A 1 271 ? 0.16113  -22.55339 10.89669  1.000 11.17418 ? 166 ALA A C   1 
ATOM   1268 O  O   . ALA A 1 271 ? 0.26639  -21.32786 10.77082  1.000 10.15131 ? 166 ALA A O   1 
ATOM   1269 C  CB  . ALA A 1 271 ? 2.08823  -23.28158 9.47407   1.000 10.10317 ? 166 ALA A CB  1 
ATOM   1270 N  N   . ARG A 1 272 ? -1.01529 -23.19090 11.08010  1.000 10.99479 ? 167 ARG A N   1 
ATOM   1271 C  CA  . ARG A 1 272 ? -2.28285 -22.44224 11.15858  1.000 10.47906 ? 167 ARG A CA  1 
ATOM   1272 C  C   . ARG A 1 272 ? -2.29594 -21.46989 12.32151  1.000 10.68386 ? 167 ARG A C   1 
ATOM   1273 O  O   . ARG A 1 272 ? -3.11251 -20.53838 12.32536  1.000 10.91703 ? 167 ARG A O   1 
ATOM   1274 C  CB  . ARG A 1 272 ? -3.44527 -23.44549 11.27654  1.000 14.10699 ? 167 ARG A CB  1 
ATOM   1275 C  CG  . ARG A 1 272 ? -3.48085 -24.12361 12.60734  1.000 22.04135 ? 167 ARG A CG  1 
ATOM   1276 C  CD  . ARG A 1 272 ? -4.27823 -25.43919 12.47757  1.000 43.32647 ? 167 ARG A CD  1 
ATOM   1277 N  NE  . ARG A 1 272 ? -5.71415 -25.21945 12.48669  1.000 44.33715 ? 167 ARG A NE  1 
ATOM   1278 C  CZ  . ARG A 1 272 ? -6.56498 -25.87794 11.71463  1.000 57.48774 ? 167 ARG A CZ  1 
ATOM   1279 N  NH1 . ARG A 1 272 ? -6.14216 -26.78009 10.84303  1.000 57.67258 ? 167 ARG A NH1 1 
ATOM   1280 N  NH2 . ARG A 1 272 ? -7.86891 -25.61016 11.80780  1.000 47.52649 ? 167 ARG A NH2 1 
ATOM   1281 N  N   . ASN A 1 273 ? -1.41800 -21.63301 13.31621  1.000 8.36138  ? 168 ASN A N   1 
ATOM   1282 C  CA  . ASN A 1 273 ? -1.45456 -20.77477 14.47981  1.000 9.58617  ? 168 ASN A CA  1 
ATOM   1283 C  C   . ASN A 1 273 ? -0.41267 -19.67204 14.43819  1.000 8.62545  ? 168 ASN A C   1 
ATOM   1284 O  O   . ASN A 1 273 ? -0.12584 -19.03218 15.46346  1.000 10.60154 ? 168 ASN A O   1 
ATOM   1285 C  CB  . ASN A 1 273 ? -1.27722 -21.61543 15.75284  1.000 8.54970  ? 168 ASN A CB  1 
ATOM   1286 C  CG  . ASN A 1 273 ? -2.54638 -22.39083 16.09980  1.000 21.32533 ? 168 ASN A CG  1 
ATOM   1287 O  OD1 . ASN A 1 273 ? -3.65381 -21.91285 15.87364  1.000 18.98270 ? 168 ASN A OD1 1 
ATOM   1288 N  ND2 . ASN A 1 273 ? -2.38811 -23.63342 16.59097  1.000 13.83149 ? 168 ASN A ND2 1 
ATOM   1289 N  N   . TYR A 1 274 ? 0.16885  -19.40797 13.26244  1.000 9.68043  ? 169 TYR A N   1 
ATOM   1290 C  CA  . TYR A 1 274 ? 1.23111  -18.42137 13.12705  1.000 9.65973  ? 169 TYR A CA  1 
ATOM   1291 C  C   . TYR A 1 274 ? 0.94929  -17.49876 11.95167  1.000 7.22796  ? 169 TYR A C   1 
ATOM   1292 O  O   . TYR A 1 274 ? 0.25992  -17.88799 11.00391  1.000 9.28781  ? 169 TYR A O   1 
ATOM   1293 C  CB  . TYR A 1 274 ? 2.63354  -19.12269 12.89497  1.000 13.27017 ? 169 TYR A CB  1 
ATOM   1294 C  CG  . TYR A 1 274 ? 2.95694  -19.99569 14.09138  1.000 9.37607  ? 169 TYR A CG  1 
ATOM   1295 C  CD1 . TYR A 1 274 ? 3.53304  -19.42912 15.21243  1.000 17.47977 ? 169 TYR A CD1 1 
ATOM   1296 C  CD2 . TYR A 1 274 ? 2.61628  -21.34426 14.09027  1.000 12.11198 ? 169 TYR A CD2 1 
ATOM   1297 C  CE1 . TYR A 1 274 ? 3.80332  -20.17239 16.33440  1.000 21.57123 ? 169 TYR A CE1 1 
ATOM   1298 C  CE2 . TYR A 1 274 ? 2.85513  -22.14257 15.26935  1.000 11.75895 ? 169 TYR A CE2 1 
ATOM   1299 C  CZ  . TYR A 1 274 ? 3.46414  -21.50015 16.36837  1.000 14.63208 ? 169 TYR A CZ  1 
ATOM   1300 O  OH  . TYR A 1 274 ? 3.78080  -22.21557 17.53313  1.000 20.61900 ? 169 TYR A OH  1 
ATOM   1301 N  N   . SER A 1 275 ? 1.48173  -16.28131 12.02325  1.000 8.91482  ? 170 SER A N   1 
ATOM   1302 C  CA  . SER A 1 275 ? 1.25549  -15.29115 10.96504  1.000 8.39038  ? 170 SER A CA  1 
ATOM   1303 C  C   . SER A 1 275 ? 2.57836  -14.65274 10.56287  1.000 8.53705  ? 170 SER A C   1 
ATOM   1304 O  O   . SER A 1 275 ? 3.44448  -14.39488 11.41208  1.000 11.47687 ? 170 SER A O   1 
ATOM   1305 C  CB  . SER A 1 275 ? 0.31514  -14.17448 11.46124  1.000 9.18028  ? 170 SER A CB  1 
ATOM   1306 O  OG  . SER A 1 275 ? -0.98512 -14.70913 11.56376  1.000 9.72302  ? 170 SER A OG  1 
ATOM   1307 N  N   . PRO A 1 276 ? 2.72676  -14.30179 9.28417   1.000 7.68156  ? 171 PRO A N   1 
ATOM   1308 C  CA  . PRO A 1 276 ? 1.73655  -14.45740 8.20485   1.000 7.90764  ? 171 PRO A CA  1 
ATOM   1309 C  C   . PRO A 1 276 ? 1.67759  -15.83107 7.56057   1.000 7.59994  ? 171 PRO A C   1 
ATOM   1310 O  O   . PRO A 1 276 ? 0.98765  -15.98819 6.54013   1.000 9.37983  ? 171 PRO A O   1 
ATOM   1311 C  CB  . PRO A 1 276 ? 2.21694  -13.40361 7.16054   1.000 7.90494  ? 171 PRO A CB  1 
ATOM   1312 C  CG  . PRO A 1 276 ? 3.67482  -13.32169 7.38018   1.000 11.30205 ? 171 PRO A CG  1 
ATOM   1313 C  CD  . PRO A 1 276 ? 3.90005  -13.51039 8.87790   1.000 9.82935  ? 171 PRO A CD  1 
ATOM   1314 N  N   . ALA A 1 277 ? 2.37670  -16.82211 8.13300   1.000 8.02492  ? 172 ALA A N   1 
ATOM   1315 C  CA  . ALA A 1 277 ? 2.34899  -18.18291 7.60127   1.000 8.59499  ? 172 ALA A CA  1 
ATOM   1316 C  C   . ALA A 1 277 ? 0.94409  -18.68178 7.28096   1.000 9.00730  ? 172 ALA A C   1 
ATOM   1317 O  O   . ALA A 1 277 ? 0.74601  -19.37968 6.28564   1.000 9.24014  ? 172 ALA A O   1 
ATOM   1318 C  CB  . ALA A 1 277 ? 2.98506  -19.15701 8.61726   1.000 10.35497 ? 172 ALA A CB  1 
ATOM   1319 N  N   . SER A 1 278 ? -0.04588 -18.34657 8.13051   1.000 6.75333  ? 173 SER A N   1 
ATOM   1320 C  CA  . SER A 1 278 ? -1.36817 -18.93114 7.98286   1.000 8.29886  ? 173 SER A CA  1 
ATOM   1321 C  C   . SER A 1 278 ? -2.26487 -18.22787 6.97153   1.000 10.28728 ? 173 SER A C   1 
ATOM   1322 O  O   . SER A 1 278 ? -3.40130 -18.66418 6.80894   1.000 11.28472 ? 173 SER A O   1 
ATOM   1323 C  CB  . SER A 1 278 ? -2.06076 -18.96233 9.36750   1.000 8.64929  ? 173 SER A CB  1 
ATOM   1324 O  OG  . SER A 1 278 ? -2.15937 -17.66997 9.92297   1.000 9.66107  ? 173 SER A OG  1 
ATOM   1325 N  N   . GLU A 1 279 ? -1.79838 -17.16228 6.30464   1.000 9.61295  ? 174 GLU A N   1 
ATOM   1326 C  CA  . GLU A 1 279 ? -2.59639 -16.49269 5.28522   1.000 8.99345  ? 174 GLU A CA  1 
ATOM   1327 C  C   . GLU A 1 279 ? -2.65131 -17.35457 4.02487   1.000 8.82418  ? 174 GLU A C   1 
ATOM   1328 O  O   . GLU A 1 279 ? -1.61772 -17.59372 3.40639   1.000 8.68954  ? 174 GLU A O   1 
ATOM   1329 C  CB  . GLU A 1 279 ? -1.97716 -15.12064 4.98589   1.000 7.51087  ? 174 GLU A CB  1 
ATOM   1330 C  CG  . GLU A 1 279 ? -2.56406 -14.42744 3.68218   1.000 9.57481  ? 174 GLU A CG  1 
ATOM   1331 C  CD  . GLU A 1 279 ? -4.11078 -14.41774 3.67111   1.000 10.63408 ? 174 GLU A CD  1 
ATOM   1332 O  OE1 . GLU A 1 279 ? -4.77032 -14.22843 4.74761   1.000 11.27860 ? 174 GLU A OE1 1 
ATOM   1333 O  OE2 . GLU A 1 279 ? -4.70450 -14.65207 2.57770   1.000 10.57730 ? 174 GLU A OE2 1 
ATOM   1334 N  N   . PRO A 1 280 ? -3.81985 -17.83312 3.58186   1.000 10.11611 ? 175 PRO A N   1 
ATOM   1335 C  CA  . PRO A 1 280 ? -3.80167 -18.83410 2.50384   1.000 9.26189  ? 175 PRO A CA  1 
ATOM   1336 C  C   . PRO A 1 280 ? -3.27547 -18.27654 1.17807   1.000 7.93113  ? 175 PRO A C   1 
ATOM   1337 O  O   . PRO A 1 280 ? -2.72899 -19.04859 0.37573   1.000 9.71856  ? 175 PRO A O   1 
ATOM   1338 C  CB  . PRO A 1 280 ? -5.28590 -19.22721 2.32221   1.000 13.58308 ? 175 PRO A CB  1 
ATOM   1339 C  CG  . PRO A 1 280 ? -5.97828 -18.72127 3.50535   1.000 22.88180 ? 175 PRO A CG  1 
ATOM   1340 C  CD  . PRO A 1 280 ? -5.09950 -17.83222 4.33232   1.000 12.02406 ? 175 PRO A CD  1 
ATOM   1341 N  N   . SER A 1 281 ? -3.48085 -16.97963 0.89596   1.000 7.42694  ? 176 SER A N   1 
ATOM   1342 C  CA  . SER A 1 281 ? -3.22372 -16.45561 -0.44519  1.000 6.63490  ? 176 SER A CA  1 
ATOM   1343 C  C   . SER A 1 281 ? -1.76783 -16.21062 -0.76188  1.000 9.88861  ? 176 SER A C   1 
ATOM   1344 O  O   . SER A 1 281 ? -1.46950 -15.88070 -1.92613  1.000 11.85073 ? 176 SER A O   1 
ATOM   1345 C  CB  . SER A 1 281 ? -4.03238 -15.15933 -0.67183  1.000 12.57348 ? 176 SER A CB  1 
ATOM   1346 O  OG  . SER A 1 281 ? -3.57174 -14.07696 0.13214   1.000 12.45675 ? 176 SER A OG  1 
ATOM   1347 N  N   . VAL A 1 282 ? -0.87567 -16.32348 0.22590   1.000 7.90237  ? 177 VAL A N   1 
ATOM   1348 C  CA  . VAL A 1 282 ? 0.55113  -16.14247 -0.05118  1.000 8.05087  ? 177 VAL A CA  1 
ATOM   1349 C  C   . VAL A 1 282 ? 1.19195  -17.52498 -0.17274  1.000 7.83721  ? 177 VAL A C   1 
ATOM   1350 O  O   . VAL A 1 282 ? 0.49383  -18.55115 -0.21151  1.000 9.67087  ? 177 VAL A O   1 
ATOM   1351 C  CB  . VAL A 1 282 ? 1.23170  -15.27521 1.03198   1.000 8.36887  ? 177 VAL A CB  1 
ATOM   1352 C  CG1 . VAL A 1 282 ? 0.50732  -13.89670 1.09554   1.000 11.24534 ? 177 VAL A CG1 1 
ATOM   1353 C  CG2 . VAL A 1 282 ? 1.19534  -15.92657 2.40678   1.000 10.90197 ? 177 VAL A CG2 1 
ATOM   1354 N  N   . CYS A 1 283 ? 2.51731  -17.56812 -0.34971  1.000 6.68967  ? 178 CYS A N   1 
ATOM   1355 C  CA  . CYS A 1 283 ? 3.20240  -18.84486 -0.55421  1.000 6.45267  ? 178 CYS A CA  1 
ATOM   1356 C  C   . CYS A 1 283 ? 3.95245  -19.18502 0.72109   1.000 8.37912  ? 178 CYS A C   1 
ATOM   1357 O  O   . CYS A 1 283 ? 4.94649  -18.54021 1.04475   1.000 8.31684  ? 178 CYS A O   1 
ATOM   1358 C  CB  . CYS A 1 283 ? 4.17864  -18.70572 -1.74181  1.000 5.78642  ? 178 CYS A CB  1 
ATOM   1359 S  SG  . CYS A 1 283 ? 4.56037  -20.26265 -2.59066  1.000 7.31215  ? 178 CYS A SG  1 
ATOM   1360 N  N   . THR A 1 284 ? 3.47598  -20.18499 1.44968   1.000 6.67364  ? 179 THR A N   1 
ATOM   1361 C  CA  . THR A 1 284 ? 4.03987  -20.51597 2.76289   1.000 4.87972  ? 179 THR A CA  1 
ATOM   1362 C  C   . THR A 1 284 ? 5.02512  -21.66793 2.60194   1.000 5.67065  ? 179 THR A C   1 
ATOM   1363 O  O   . THR A 1 284 ? 4.67900  -22.71199 2.04621   1.000 7.51953  ? 179 THR A O   1 
ATOM   1364 C  CB  . THR A 1 284 ? 2.90097  -20.89707 3.69735   1.000 7.57369  ? 179 THR A CB  1 
ATOM   1365 O  OG1 . THR A 1 284 ? 2.04111  -19.76355 3.78782   1.000 7.99077  ? 179 THR A OG1 1 
ATOM   1366 C  CG2 . THR A 1 284 ? 3.42149  -21.29351 5.13063   1.000 8.43765  ? 179 THR A CG2 1 
ATOM   1367 N  N   . VAL A 1 285 ? 6.24593  -21.46717 3.10577   1.000 4.84980  ? 180 VAL A N   1 
ATOM   1368 C  CA  . VAL A 1 285 ? 7.41458  -22.30586 2.77056   1.000 6.20126  ? 180 VAL A CA  1 
ATOM   1369 C  C   . VAL A 1 285 ? 7.92336  -23.04152 3.99377   1.000 6.15365  ? 180 VAL A C   1 
ATOM   1370 O  O   . VAL A 1 285 ? 8.33963  -22.41881 4.98200   1.000 8.05614  ? 180 VAL A O   1 
ATOM   1371 C  CB  . VAL A 1 285 ? 8.53280  -21.41477 2.18570   1.000 5.36253  ? 180 VAL A CB  1 
ATOM   1372 C  CG1 . VAL A 1 285 ? 9.73687  -22.31900 1.73552   1.000 8.67384  ? 180 VAL A CG1 1 
ATOM   1373 C  CG2 . VAL A 1 285 ? 8.01127  -20.65063 0.98546   1.000 6.21266  ? 180 VAL A CG2 1 
ATOM   1374 N  N   . GLY A 1 286 ? 7.93284  -24.40200 3.91590   1.000 5.93391  ? 181 GLY A N   1 
ATOM   1375 C  CA  . GLY A 1 286 ? 8.58137  -25.21857 4.95562   1.000 6.77900  ? 181 GLY A CA  1 
ATOM   1376 C  C   . GLY A 1 286 ? 10.05275 -25.50840 4.60870   1.000 5.95174  ? 181 GLY A C   1 
ATOM   1377 O  O   . GLY A 1 286 ? 10.52283 -25.20620 3.51488   1.000 7.27333  ? 181 GLY A O   1 
ATOM   1378 N  N   . ALA A 1 287 ? 10.76132 -26.13837 5.53419   1.000 5.19765  ? 182 ALA A N   1 
ATOM   1379 C  CA  . ALA A 1 287 ? 12.19530 -26.40755 5.35386   1.000 7.56915  ? 182 ALA A CA  1 
ATOM   1380 C  C   . ALA A 1 287 ? 12.49521 -27.90340 5.25230   1.000 8.35954  ? 182 ALA A C   1 
ATOM   1381 O  O   . ALA A 1 287 ? 11.92003 -28.71324 5.99725   1.000 7.44566  ? 182 ALA A O   1 
ATOM   1382 C  CB  . ALA A 1 287 ? 13.00863 -25.82184 6.54119   1.000 6.07545  ? 182 ALA A CB  1 
ATOM   1383 N  N   . SER A 1 288 ? 13.49560 -28.21954 4.39657   1.000 5.72888  ? 183 SER A N   1 
ATOM   1384 C  CA  . SER A 1 288 ? 14.03310 -29.58001 4.34367   1.000 6.23600  ? 183 SER A CA  1 
ATOM   1385 C  C   . SER A 1 288 ? 15.53850 -29.58668 4.56919   1.000 7.45231  ? 183 SER A C   1 
ATOM   1386 O  O   . SER A 1 288 ? 16.21470 -28.56442 4.47691   1.000 8.57030  ? 183 SER A O   1 
ATOM   1387 C  CB  . SER A 1 288 ? 13.69430 -30.21661 2.98073   1.000 7.83438  ? 183 SER A CB  1 
ATOM   1388 O  OG  . SER A 1 288 ? 14.36987 -29.50874 1.95293   1.000 10.68544 ? 183 SER A OG  1 
ATOM   1389 N  N   . ASP A 1 289 ? 16.09413 -30.78431 4.78853   1.000 8.58745  ? 184 ASP A N   1 
ATOM   1390 C  CA  . ASP A 1 289 ? 17.53742 -30.91862 4.96294   1.000 6.76799  ? 184 ASP A CA  1 
ATOM   1391 C  C   . ASP A 1 289 ? 18.15897 -31.67614 3.78439   1.000 9.06995  ? 184 ASP A C   1 
ATOM   1392 O  O   . ASP A 1 289 ? 17.48380 -32.07141 2.85585   1.000 8.40920  ? 184 ASP A O   1 
ATOM   1393 C  CB  . ASP A 1 289 ? 17.88347 -31.58183 6.32880   1.000 7.24640  ? 184 ASP A CB  1 
ATOM   1394 C  CG  . ASP A 1 289 ? 17.56472 -33.12546 6.41829   1.000 10.42557 ? 184 ASP A CG  1 
ATOM   1395 O  OD1 . ASP A 1 289 ? 17.36405 -33.79063 5.37669   1.000 9.38319  ? 184 ASP A OD1 1 
ATOM   1396 O  OD2 . ASP A 1 289 ? 17.55438 -33.59122 7.59075   1.000 13.09167 ? 184 ASP A OD2 1 
ATOM   1397 N  N   . ARG A 1 290 ? 19.50055 -31.85168 3.82197   1.000 8.16834  ? 185 ARG A N   1 
ATOM   1398 C  CA  . ARG A 1 290 ? 20.17679 -32.34311 2.62663   1.000 8.94432  ? 185 ARG A CA  1 
ATOM   1399 C  C   . ARG A 1 290 ? 19.96704 -33.83008 2.36549   1.000 9.86994  ? 185 ARG A C   1 
ATOM   1400 O  O   . ARG A 1 290 ? 20.33206 -34.29657 1.28970   1.000 12.93824 ? 185 ARG A O   1 
ATOM   1401 C  CB  . ARG A 1 290 ? 21.67167 -32.01747 2.74755   1.000 14.08238 ? 185 ARG A CB  1 
ATOM   1402 C  CG  . ARG A 1 290 ? 22.32558 -32.99662 3.67411   1.000 17.31735 ? 185 ARG A CG  1 
ATOM   1403 C  CD  . ARG A 1 290 ? 23.87702 -32.84511 3.59348   1.000 27.47531 ? 185 ARG A CD  1 
ATOM   1404 N  NE  . ARG A 1 290 ? 24.33119 -31.55483 4.08062   1.000 32.12133 ? 185 ARG A NE  1 
ATOM   1405 C  CZ  . ARG A 1 290 ? 25.27930 -30.83642 3.48765   1.000 44.53331 ? 185 ARG A CZ  1 
ATOM   1406 N  NH1 . ARG A 1 290 ? 25.78111 -31.19139 2.31329   1.000 37.45663 ? 185 ARG A NH1 1 
ATOM   1407 N  NH2 . ARG A 1 290 ? 25.71566 -29.72217 4.07448   1.000 37.01325 ? 185 ARG A NH2 1 
ATOM   1408 N  N   . TYR A 1 291 ? 19.31992 -34.54449 3.26137   1.000 10.29313 ? 186 TYR A N   1 
ATOM   1409 C  CA  . TYR A 1 291 ? 18.90294 -35.93314 3.04987   1.000 12.17710 ? 186 TYR A CA  1 
ATOM   1410 C  C   . TYR A 1 291 ? 17.43123 -36.06752 2.68924   1.000 13.17304 ? 186 TYR A C   1 
ATOM   1411 O  O   . TYR A 1 291 ? 16.87863 -37.18785 2.73094   1.000 12.37726 ? 186 TYR A O   1 
ATOM   1412 C  CB  . TYR A 1 291 ? 19.24135 -36.77842 4.27866   1.000 11.25248 ? 186 TYR A CB  1 
ATOM   1413 C  CG  . TYR A 1 291 ? 20.72477 -36.75990 4.62956   1.000 15.13372 ? 186 TYR A CG  1 
ATOM   1414 C  CD1 . TYR A 1 291 ? 21.62307 -37.44640 3.82833   1.000 27.35964 ? 186 TYR A CD1 1 
ATOM   1415 C  CD2 . TYR A 1 291 ? 21.21666 -35.90147 5.60095   1.000 17.78006 ? 186 TYR A CD2 1 
ATOM   1416 C  CE1 . TYR A 1 291 ? 22.98205 -37.41193 4.10710   1.000 29.40211 ? 186 TYR A CE1 1 
ATOM   1417 C  CE2 . TYR A 1 291 ? 22.56458 -35.85425 5.87634   1.000 26.60087 ? 186 TYR A CE2 1 
ATOM   1418 C  CZ  . TYR A 1 291 ? 23.43272 -36.61562 5.12747   1.000 29.38807 ? 186 TYR A CZ  1 
ATOM   1419 O  OH  . TYR A 1 291 ? 24.78584 -36.56436 5.39731   1.000 37.76971 ? 186 TYR A OH  1 
ATOM   1420 N  N   . ASP A 1 292 ? 16.78039 -34.95554 2.31643   1.000 9.01761  ? 187 ASP A N   1 
ATOM   1421 C  CA  . ASP A 1 292 ? 15.38690 -34.93071 1.92907   1.000 9.19322  ? 187 ASP A CA  1 
ATOM   1422 C  C   . ASP A 1 292 ? 14.46471 -35.33123 3.07624   1.000 9.35838  ? 187 ASP A C   1 
ATOM   1423 O  O   . ASP A 1 292 ? 13.38885 -35.88911 2.83230   1.000 12.81662 ? 187 ASP A O   1 
ATOM   1424 C  CB  . ASP A 1 292 ? 15.12634 -35.80716 0.68757   1.000 12.18777 ? 187 ASP A CB  1 
ATOM   1425 C  CG  . ASP A 1 292 ? 15.49844 -35.11762 -0.60937  1.000 16.64024 ? 187 ASP A CG  1 
ATOM   1426 O  OD1 . ASP A 1 292 ? 15.89557 -33.93425 -0.60153  1.000 12.07471 ? 187 ASP A OD1 1 
ATOM   1427 O  OD2 . ASP A 1 292 ? 15.41530 -35.79360 -1.67003  1.000 14.92091 ? 187 ASP A OD2 1 
ATOM   1428 N  N   . ARG A 1 293 ? 14.83090 -34.98115 4.31600   1.000 9.77801  ? 188 ARG A N   1 
ATOM   1429 C  CA  . ARG A 1 293 ? 13.89765 -35.04623 5.43799   1.000 8.55423  ? 188 ARG A CA  1 
ATOM   1430 C  C   . ARG A 1 293 ? 13.29645 -33.67526 5.69624   1.000 8.41183  ? 188 ARG A C   1 
ATOM   1431 O  O   . ARG A 1 293 ? 13.95921 -32.66798 5.47637   1.000 10.34139 ? 188 ARG A O   1 
ATOM   1432 C  CB  . ARG A 1 293 ? 14.60935 -35.50961 6.70163   1.000 8.36015  ? 188 ARG A CB  1 
ATOM   1433 C  CG  . ARG A 1 293 ? 15.30956 -36.84214 6.43577   1.000 11.67404 ? 188 ARG A CG  1 
ATOM   1434 C  CD  . ARG A 1 293 ? 16.00832 -37.30697 7.71218   1.000 15.64187 ? 188 ARG A CD  1 
ATOM   1435 N  NE  . ARG A 1 293 ? 17.15710 -36.45139 7.96427   1.000 19.16046 ? 188 ARG A NE  1 
ATOM   1436 C  CZ  . ARG A 1 293 ? 18.35215 -36.84617 8.38934   1.000 12.92588 ? 188 ARG A CZ  1 
ATOM   1437 N  NH1 . ARG A 1 293 ? 18.61349 -38.11699 8.68116   1.000 14.90177 ? 188 ARG A NH1 1 
ATOM   1438 N  NH2 . ARG A 1 293 ? 19.29215 -35.94414 8.56688   1.000 14.58439 ? 188 ARG A NH2 1 
ATOM   1439 N  N   . ARG A 1 294 ? 12.02363 -33.63006 6.12356   1.000 8.23061  ? 189 ARG A N   1 
ATOM   1440 C  CA  . ARG A 1 294 ? 11.55336 -32.38853 6.72865   1.000 9.74655  ? 189 ARG A CA  1 
ATOM   1441 C  C   . ARG A 1 294 ? 12.51958 -31.97360 7.83682   1.000 8.55031  ? 189 ARG A C   1 
ATOM   1442 O  O   . ARG A 1 294 ? 12.93505 -32.79150 8.67683   1.000 9.36260  ? 189 ARG A O   1 
ATOM   1443 C  CB  . ARG A 1 294 ? 10.12121 -32.56306 7.27385   1.000 8.84907  ? 189 ARG A CB  1 
ATOM   1444 C  CG  . ARG A 1 294 ? 9.62361  -31.31650 7.97765   1.000 10.12744 ? 189 ARG A CG  1 
ATOM   1445 C  CD  . ARG A 1 294 ? 8.16353  -31.44619 8.47213   1.000 11.81971 ? 189 ARG A CD  1 
ATOM   1446 N  NE  . ARG A 1 294 ? 8.02024  -32.48885 9.46993   1.000 12.93172 ? 189 ARG A NE  1 
ATOM   1447 C  CZ  . ARG A 1 294 ? 8.07953  -32.29386 10.78596  1.000 17.76767 ? 189 ARG A CZ  1 
ATOM   1448 N  NH1 . ARG A 1 294 ? 8.25205  -31.08745 11.30915  1.000 15.10204 ? 189 ARG A NH1 1 
ATOM   1449 N  NH2 . ARG A 1 294 ? 7.98616  -33.34237 11.61168  1.000 22.00832 ? 189 ARG A NH2 1 
ATOM   1450 N  N   . SER A 1 295 ? 12.92628 -30.71298 7.82439   1.000 7.44240  ? 190 SER A N   1 
ATOM   1451 C  CA  . SER A 1 295 ? 13.78191 -30.21641 8.89665   1.000 6.75829  ? 190 SER A CA  1 
ATOM   1452 C  C   . SER A 1 295 ? 13.10076 -30.39354 10.24480  1.000 6.75741  ? 190 SER A C   1 
ATOM   1453 O  O   . SER A 1 295 ? 11.88247 -30.20699 10.39534  1.000 10.18546 ? 190 SER A O   1 
ATOM   1454 C  CB  . SER A 1 295 ? 14.12312 -28.71790 8.70138   1.000 8.63852  ? 190 SER A CB  1 
ATOM   1455 O  OG  . SER A 1 295 ? 14.84315 -28.48980 7.47694   1.000 8.65890  ? 190 SER A OG  1 
ATOM   1456 N  N   . SER A 1 296 ? 13.89536 -30.78052 11.24983  1.000 9.83295  ? 191 SER A N   1 
ATOM   1457 C  CA  . SER A 1 296 ? 13.23516 -31.20064 12.48580  1.000 8.99677  ? 191 SER A CA  1 
ATOM   1458 C  C   . SER A 1 296 ? 12.43890 -30.09645 13.17531  1.000 12.57903 ? 191 SER A C   1 
ATOM   1459 O  O   . SER A 1 296 ? 11.54309 -30.42181 13.95855  1.000 13.94066 ? 191 SER A O   1 
ATOM   1460 C  CB  . SER A 1 296 ? 14.27482 -31.71914 13.47552  1.000 12.52903 ? 191 SER A CB  1 
ATOM   1461 O  OG  . SER A 1 296 ? 15.19793 -30.70086 13.76892  1.000 20.44419 ? 191 SER A OG  1 
ATOM   1462 N  N   . PHE A 1 297 ? 12.77716 -28.81894 12.92961  1.000 8.40320  ? 192 PHE A N   1 
ATOM   1463 C  CA  . PHE A 1 297 ? 12.07954 -27.67281 13.47981  1.000 7.86839  ? 192 PHE A CA  1 
ATOM   1464 C  C   . PHE A 1 297 ? 10.95106 -27.18220 12.59645  1.000 7.29578  ? 192 PHE A C   1 
ATOM   1465 O  O   . PHE A 1 297 ? 10.20013 -26.28401 13.03571  1.000 10.10057 ? 192 PHE A O   1 
ATOM   1466 C  CB  . PHE A 1 297 ? 13.07042 -26.49300 13.64372  1.000 9.00576  ? 192 PHE A CB  1 
ATOM   1467 C  CG  . PHE A 1 297 ? 13.90665 -26.23569 12.41430  1.000 9.36053  ? 192 PHE A CG  1 
ATOM   1468 C  CD1 . PHE A 1 297 ? 13.38048 -25.48178 11.33245  1.000 10.50575 ? 192 PHE A CD1 1 
ATOM   1469 C  CD2 . PHE A 1 297 ? 15.18774 -26.77607 12.27634  1.000 10.89189 ? 192 PHE A CD2 1 
ATOM   1470 C  CE1 . PHE A 1 297 ? 14.09670 -25.24103 10.21745  1.000 10.44012 ? 192 PHE A CE1 1 
ATOM   1471 C  CE2 . PHE A 1 297 ? 15.93219 -26.54350 11.12877  1.000 8.93889  ? 192 PHE A CE2 1 
ATOM   1472 C  CZ  . PHE A 1 297 ? 15.38128 -25.78455 10.09093  1.000 10.84764 ? 192 PHE A CZ  1 
ATOM   1473 N  N   . SER A 1 298 ? 10.81332 -27.68998 11.35788  1.000 7.85542  ? 193 SER A N   1 
ATOM   1474 C  CA  . SER A 1 298 ? 9.90040  -27.00592 10.41594  1.000 7.81736  ? 193 SER A CA  1 
ATOM   1475 C  C   . SER A 1 298 ? 8.44321  -27.17453 10.84246  1.000 7.46506  ? 193 SER A C   1 
ATOM   1476 O  O   . SER A 1 298 ? 7.99090  -28.29526 11.13837  1.000 11.06549 ? 193 SER A O   1 
ATOM   1477 C  CB  . SER A 1 298 ? 10.06840 -27.57218 8.99744   1.000 9.66019  ? 193 SER A CB  1 
ATOM   1478 O  OG  . SER A 1 298 ? 9.18978  -26.87118 8.10100   1.000 8.85691  ? 193 SER A OG  1 
ATOM   1479 N  N   . ASN A 1 299 ? 7.67655  -26.07913 10.83985  1.000 7.18389  ? 194 ASN A N   1 
ATOM   1480 C  CA  . ASN A 1 299 ? 6.22138  -26.23481 10.91244  1.000 6.31342  ? 194 ASN A CA  1 
ATOM   1481 C  C   . ASN A 1 299 ? 5.68295  -26.97769 9.69888   1.000 9.79390  ? 194 ASN A C   1 
ATOM   1482 O  O   . ASN A 1 299 ? 6.34354  -27.15496 8.65584   1.000 11.03282 ? 194 ASN A O   1 
ATOM   1483 C  CB  . ASN A 1 299 ? 5.55025  -24.85233 11.03007  1.000 7.79179  ? 194 ASN A CB  1 
ATOM   1484 C  CG  . ASN A 1 299 ? 5.67890  -24.24882 12.42292  1.000 12.13271 ? 194 ASN A CG  1 
ATOM   1485 O  OD1 . ASN A 1 299 ? 6.15069  -24.88356 13.37980  1.000 10.36494 ? 194 ASN A OD1 1 
ATOM   1486 N  ND2 . ASN A 1 299 ? 5.29352  -22.97467 12.54211  1.000 9.78642  ? 194 ASN A ND2 1 
ATOM   1487 N  N   . TYR A 1 300 ? 4.42600  -27.44136 9.82961   1.000 10.38388 ? 195 TYR A N   1 
ATOM   1488 C  CA  . TYR A 1 300 ? 3.79735  -28.24648 8.78653   1.000 9.11692  ? 195 TYR A CA  1 
ATOM   1489 C  C   . TYR A 1 300 ? 2.31214  -27.89187 8.76364   1.000 8.01718  ? 195 TYR A C   1 
ATOM   1490 O  O   . TYR A 1 300 ? 1.88788  -26.92447 9.40002   1.000 12.83269 ? 195 TYR A O   1 
ATOM   1491 C  CB  . TYR A 1 300 ? 4.01013  -29.76583 9.03294   1.000 10.69896 ? 195 TYR A CB  1 
ATOM   1492 C  CG  . TYR A 1 300 ? 3.65313  -30.15398 10.45525  1.000 13.76614 ? 195 TYR A CG  1 
ATOM   1493 C  CD1 . TYR A 1 300 ? 2.34093  -30.43704 10.80136  1.000 12.15768 ? 195 TYR A CD1 1 
ATOM   1494 C  CD2 . TYR A 1 300 ? 4.63591  -30.19796 11.45445  1.000 13.95953 ? 195 TYR A CD2 1 
ATOM   1495 C  CE1 . TYR A 1 300 ? 2.01132  -30.77049 12.11231  1.000 22.26622 ? 195 TYR A CE1 1 
ATOM   1496 C  CE2 . TYR A 1 300 ? 4.30884  -30.52661 12.75327  1.000 18.29091 ? 195 TYR A CE2 1 
ATOM   1497 C  CZ  . TYR A 1 300 ? 2.99809  -30.83101 13.06908  1.000 26.64525 ? 195 TYR A CZ  1 
ATOM   1498 O  OH  . TYR A 1 300 ? 2.69112  -31.17167 14.37161  1.000 28.28917 ? 195 TYR A OH  1 
ATOM   1499 N  N   . GLY A 1 301 ? 1.52363  -28.66024 8.03626   1.000 9.70614  ? 196 GLY A N   1 
ATOM   1500 C  CA  . GLY A 1 301 ? 0.08565  -28.41688 8.02520   1.000 10.63505 ? 196 GLY A CA  1 
ATOM   1501 C  C   . GLY A 1 301 ? -0.44702 -28.12446 6.63381   1.000 11.91918 ? 196 GLY A C   1 
ATOM   1502 O  O   . GLY A 1 301 ? 0.28914  -27.95367 5.66724   1.000 11.66423 ? 196 GLY A O   1 
ATOM   1503 N  N   . SER A 1 302 ? -1.78314 -28.06057 6.55274   1.000 10.19480 ? 197 SER A N   1 
ATOM   1504 C  CA  . SER A 1 302 ? -2.42420 -27.87905 5.23747   1.000 10.29360 ? 197 SER A CA  1 
ATOM   1505 C  C   . SER A 1 302 ? -2.13738 -26.52699 4.57909   1.000 9.85078  ? 197 SER A C   1 
ATOM   1506 O  O   . SER A 1 302 ? -2.30632 -26.41584 3.35893   1.000 13.14540 ? 197 SER A O   1 
ATOM   1507 C  CB  . SER A 1 302 ? -3.95235 -28.03203 5.36371   1.000 16.28370 ? 197 SER A CB  1 
ATOM   1508 O  OG  . SER A 1 302 ? -4.42674 -27.10867 6.28485   1.000 20.34087 ? 197 SER A OG  1 
ATOM   1509 N  N   A VAL A 1 303 ? -1.74622 -25.51145 5.35115   0.582 10.55443 ? 198 VAL A N   1 
ATOM   1510 N  N   B VAL A 1 303 ? -1.70879 -25.51918 5.35019   0.418 10.54380 ? 198 VAL A N   1 
ATOM   1511 C  CA  A VAL A 1 303 ? -1.50834 -24.21020 4.72218   0.582 7.66464  ? 198 VAL A CA  1 
ATOM   1512 C  CA  B VAL A 1 303 ? -1.44865 -24.18371 4.80007   0.418 7.75126  ? 198 VAL A CA  1 
ATOM   1513 C  C   A VAL A 1 303 ? -0.17595 -24.17860 3.96272   0.582 8.08960  ? 198 VAL A C   1 
ATOM   1514 C  C   B VAL A 1 303 ? -0.05364 -24.04052 4.20434   0.418 8.24687  ? 198 VAL A C   1 
ATOM   1515 O  O   A VAL A 1 303 ? -0.01900 -23.32823 3.05046   0.582 8.81288  ? 198 VAL A O   1 
ATOM   1516 O  O   B VAL A 1 303 ? 0.27852  -22.96312 3.65763   0.418 8.27401  ? 198 VAL A O   1 
ATOM   1517 C  CB  A VAL A 1 303 ? -1.60853 -23.05780 5.75120   0.582 10.85141 ? 198 VAL A CB  1 
ATOM   1518 C  CB  B VAL A 1 303 ? -1.64926 -23.10898 5.87954   0.418 10.84196 ? 198 VAL A CB  1 
ATOM   1519 C  CG1 A VAL A 1 303 ? -0.37299 -22.94052 6.66679   0.582 11.43531 ? 198 VAL A CG1 1 
ATOM   1520 C  CG1 B VAL A 1 303 ? -3.06154 -23.19722 6.36328   0.418 11.64411 ? 198 VAL A CG1 1 
ATOM   1521 C  CG2 A VAL A 1 303 ? -1.92152 -21.70994 5.01791   0.582 7.96602  ? 198 VAL A CG2 1 
ATOM   1522 C  CG2 B VAL A 1 303 ? -0.64871 -23.30850 7.00575   0.418 11.49237 ? 198 VAL A CG2 1 
ATOM   1523 N  N   . LEU A 1 304 ? 0.76697  -25.08798 4.27152   1.000 8.50054  ? 199 LEU A N   1 
ATOM   1524 C  CA  . LEU A 1 304 ? 2.04596  -25.05174 3.56151   1.000 6.76715  ? 199 LEU A CA  1 
ATOM   1525 C  C   . LEU A 1 304 ? 1.79806  -25.25800 2.08472   1.000 8.57537  ? 199 LEU A C   1 
ATOM   1526 O  O   . LEU A 1 304 ? 0.97353  -26.11432 1.67665   1.000 9.36360  ? 199 LEU A O   1 
ATOM   1527 C  CB  . LEU A 1 304 ? 2.98374  -26.14368 4.02999   1.000 8.30825  ? 199 LEU A CB  1 
ATOM   1528 C  CG  . LEU A 1 304 ? 3.94353  -25.65120 5.10921   1.000 12.27759 ? 199 LEU A CG  1 
ATOM   1529 C  CD1 . LEU A 1 304 ? 3.18595  -25.38102 6.40866   1.000 12.29180 ? 199 LEU A CD1 1 
ATOM   1530 C  CD2 . LEU A 1 304 ? 5.03867  -26.68574 5.30692   1.000 14.10692 ? 199 LEU A CD2 1 
ATOM   1531 N  N   . ASP A 1 305 ? 2.56362  -24.52125 1.25869   1.000 6.03936  ? 200 ASP A N   1 
ATOM   1532 C  CA  . ASP A 1 305 ? 2.44943  -24.66582 -0.19010  1.000 5.28439  ? 200 ASP A CA  1 
ATOM   1533 C  C   . ASP A 1 305 ? 3.59342  -25.47764 -0.77947  1.000 7.66707  ? 200 ASP A C   1 
ATOM   1534 O  O   . ASP A 1 305 ? 3.41863  -26.09419 -1.84695  1.000 9.79625  ? 200 ASP A O   1 
ATOM   1535 C  CB  . ASP A 1 305 ? 2.46080  -23.27165 -0.88773  1.000 5.92815  ? 200 ASP A CB  1 
ATOM   1536 C  CG  . ASP A 1 305 ? 1.22907  -22.45587 -0.53956  1.000 9.71625  ? 200 ASP A CG  1 
ATOM   1537 O  OD1 . ASP A 1 305 ? 0.17808  -22.80531 -1.11337  1.000 11.62240 ? 200 ASP A OD1 1 
ATOM   1538 O  OD2 . ASP A 1 305 ? 1.27022  -21.56605 0.32010   1.000 8.19690  ? 200 ASP A OD2 1 
ATOM   1539 N  N   . ILE A 1 306 ? 4.77347  -25.43985 -0.13583  1.000 6.79731  ? 201 ILE A N   1 
ATOM   1540 C  CA  . ILE A 1 306 ? 6.00346  -25.90799 -0.79165  1.000 6.54750  ? 201 ILE A CA  1 
ATOM   1541 C  C   . ILE A 1 306 ? 7.09296  -26.02420 0.25493   1.000 6.75288  ? 201 ILE A C   1 
ATOM   1542 O  O   . ILE A 1 306 ? 7.03944  -25.33329 1.26715   1.000 7.88343  ? 201 ILE A O   1 
ATOM   1543 C  CB  . ILE A 1 306 ? 6.40538  -24.90357 -1.91534  1.000 6.71400  ? 201 ILE A CB  1 
ATOM   1544 C  CG1 . ILE A 1 306 ? 7.57114  -25.41512 -2.76340  1.000 8.07209  ? 201 ILE A CG1 1 
ATOM   1545 C  CG2 . ILE A 1 306 ? 6.82596  -23.55848 -1.32303  1.000 8.45598  ? 201 ILE A CG2 1 
ATOM   1546 C  CD1 . ILE A 1 306 ? 7.10850  -26.54756 -3.70327  1.000 10.50199 ? 201 ILE A CD1 1 
ATOM   1547 N  N   . PHE A 1 307 ? 8.06256  -26.90744 0.03814   1.000 7.06209  ? 202 PHE A N   1 
ATOM   1548 C  CA  . PHE A 1 307 ? 9.26210  -26.96066 0.88244   1.000 5.85140  ? 202 PHE A CA  1 
ATOM   1549 C  C   . PHE A 1 307 ? 10.46997 -26.50432 0.08244   1.000 8.02823  ? 202 PHE A C   1 
ATOM   1550 O  O   . PHE A 1 307 ? 10.51149 -26.63773 -1.14613  1.000 8.58925  ? 202 PHE A O   1 
ATOM   1551 C  CB  . PHE A 1 307 ? 9.51675  -28.42032 1.35301   1.000 7.84436  ? 202 PHE A CB  1 
ATOM   1552 C  CG  . PHE A 1 307 ? 8.65212  -28.83182 2.50075   1.000 8.52312  ? 202 PHE A CG  1 
ATOM   1553 C  CD1 . PHE A 1 307 ? 7.33126  -29.25950 2.27251   1.000 9.37708  ? 202 PHE A CD1 1 
ATOM   1554 C  CD2 . PHE A 1 307 ? 9.12916  -28.75270 3.80798   1.000 9.21658  ? 202 PHE A CD2 1 
ATOM   1555 C  CE1 . PHE A 1 307 ? 6.53019  -29.60605 3.35492   1.000 11.07847 ? 202 PHE A CE1 1 
ATOM   1556 C  CE2 . PHE A 1 307 ? 8.36522  -29.08056 4.88247   1.000 8.93725  ? 202 PHE A CE2 1 
ATOM   1557 C  CZ  . PHE A 1 307 ? 7.04973  -29.53860 4.65633   1.000 11.58293 ? 202 PHE A CZ  1 
ATOM   1558 N  N   . GLY A 1 308 ? 11.45194 -25.93246 0.77792   1.000 6.47247  ? 203 GLY A N   1 
ATOM   1559 C  CA  . GLY A 1 308 ? 12.73246 -25.62799 0.16768   1.000 8.80148  ? 203 GLY A CA  1 
ATOM   1560 C  C   . GLY A 1 308 ? 13.84612 -25.93269 1.16562   1.000 7.52302  ? 203 GLY A C   1 
ATOM   1561 O  O   . GLY A 1 308 ? 13.61271 -26.16283 2.35483   1.000 7.53335  ? 203 GLY A O   1 
ATOM   1562 N  N   . PRO A 1 309 ? 15.09547 -25.90182 0.71516   1.000 7.70233  ? 204 PRO A N   1 
ATOM   1563 C  CA  . PRO A 1 309 ? 16.20970 -26.23165 1.61361   1.000 5.15664  ? 204 PRO A CA  1 
ATOM   1564 C  C   . PRO A 1 309 ? 16.34100 -25.24321 2.76364   1.000 4.89480  ? 204 PRO A C   1 
ATOM   1565 O  O   . PRO A 1 309 ? 16.36850 -24.00876 2.54444   1.000 7.80076  ? 204 PRO A O   1 
ATOM   1566 C  CB  . PRO A 1 309 ? 17.44122 -26.13662 0.68843   1.000 8.20351  ? 204 PRO A CB  1 
ATOM   1567 C  CG  . PRO A 1 309 ? 16.86728 -26.40143 -0.67910  1.000 8.34391  ? 204 PRO A CG  1 
ATOM   1568 C  CD  . PRO A 1 309 ? 15.51935 -25.75606 -0.70254  1.000 11.91621 ? 204 PRO A CD  1 
ATOM   1569 N  N   . GLY A 1 310 ? 16.41295 -25.79000 3.99354   1.000 6.35443  ? 205 GLY A N   1 
ATOM   1570 C  CA  . GLY A 1 310 ? 16.44401 -24.89787 5.17122   1.000 6.15898  ? 205 GLY A CA  1 
ATOM   1571 C  C   . GLY A 1 310 ? 17.43058 -25.27394 6.26134   1.000 8.25390  ? 205 GLY A C   1 
ATOM   1572 O  O   . GLY A 1 310 ? 17.63612 -24.47505 7.18054   1.000 10.42154 ? 205 GLY A O   1 
ATOM   1573 N  N   . THR A 1 311 ? 18.05765 -26.44603 6.21738   1.000 6.56129  ? 206 THR A N   1 
ATOM   1574 C  CA  . THR A 1 311 ? 19.02651 -26.81912 7.26367   1.000 4.49447  ? 206 THR A CA  1 
ATOM   1575 C  C   . THR A 1 311 ? 20.45555 -26.66630 6.73856   1.000 7.28693  ? 206 THR A C   1 
ATOM   1576 O  O   . THR A 1 311 ? 20.77568 -27.19590 5.67545   1.000 9.82675  ? 206 THR A O   1 
ATOM   1577 C  CB  . THR A 1 311 ? 18.77403 -28.28259 7.68737   1.000 7.40953  ? 206 THR A CB  1 
ATOM   1578 O  OG1 . THR A 1 311 ? 17.44810 -28.38188 8.25180   1.000 10.66448 ? 206 THR A OG1 1 
ATOM   1579 C  CG2 . THR A 1 311 ? 19.79031 -28.74245 8.71028   1.000 7.88074  ? 206 THR A CG2 1 
ATOM   1580 N  N   A ASP A 1 312 ? 21.29703 -25.92862 7.48110   0.627 7.08739  ? 207 ASP A N   1 
ATOM   1581 N  N   B ASP A 1 312 ? 21.30012 -25.94915 7.48837   0.373 7.14502  ? 207 ASP A N   1 
ATOM   1582 C  CA  A ASP A 1 312 ? 22.72381 -25.79241 7.19829   0.627 7.66284  ? 207 ASP A CA  1 
ATOM   1583 C  CA  B ASP A 1 312 ? 22.71637 -25.82261 7.16680   0.373 7.69667  ? 207 ASP A CA  1 
ATOM   1584 C  C   A ASP A 1 312 ? 22.95461 -25.10528 5.85334   0.627 7.18631  ? 207 ASP A C   1 
ATOM   1585 C  C   B ASP A 1 312 ? 22.89914 -25.13179 5.81427   0.373 7.28677  ? 207 ASP A C   1 
ATOM   1586 O  O   A ASP A 1 312 ? 23.56776 -25.66062 4.93466   0.627 8.80855  ? 207 ASP A O   1 
ATOM   1587 O  O   B ASP A 1 312 ? 23.42168 -25.70977 4.85220   0.373 8.68428  ? 207 ASP A O   1 
ATOM   1588 C  CB  A ASP A 1 312 ? 23.41874 -27.16737 7.25114   0.627 9.07882  ? 207 ASP A CB  1 
ATOM   1589 C  CB  B ASP A 1 312 ? 23.39020 -27.20925 7.19643   0.373 9.10028  ? 207 ASP A CB  1 
ATOM   1590 C  CG  A ASP A 1 312 ? 23.48865 -27.72038 8.63405   0.627 12.18404 ? 207 ASP A CG  1 
ATOM   1591 C  CG  B ASP A 1 312 ? 24.90449 -27.12968 7.22319   0.373 14.11978 ? 207 ASP A CG  1 
ATOM   1592 O  OD1 A ASP A 1 312 ? 23.45418 -26.93516 9.60851   0.627 12.63945 ? 207 ASP A OD1 1 
ATOM   1593 O  OD1 B ASP A 1 312 ? 25.45001 -26.10655 7.67292   0.373 15.93439 ? 207 ASP A OD1 1 
ATOM   1594 O  OD2 A ASP A 1 312 ? 23.56684 -28.96364 8.75702   0.627 17.39963 ? 207 ASP A OD2 1 
ATOM   1595 O  OD2 B ASP A 1 312 ? 25.54790 -28.12210 6.79544   0.373 18.22406 ? 207 ASP A OD2 1 
ATOM   1596 N  N   . ILE A 1 313 ? 22.41785 -23.88449 5.74197   1.000 6.59211  ? 208 ILE A N   1 
ATOM   1597 C  CA  . ILE A 1 313 ? 22.42891 -23.09852 4.51116   1.000 6.31893  ? 208 ILE A CA  1 
ATOM   1598 C  C   . ILE A 1 313 ? 23.51891 -22.02477 4.58304   1.000 6.25473  ? 208 ILE A C   1 
ATOM   1599 O  O   . ILE A 1 313 ? 23.47674 -21.13907 5.45524   1.000 6.75150  ? 208 ILE A O   1 
ATOM   1600 C  CB  . ILE A 1 313 ? 21.05228 -22.44557 4.27554   1.000 6.60131  ? 208 ILE A CB  1 
ATOM   1601 C  CG1 . ILE A 1 313 ? 19.93733 -23.50913 4.23970   1.000 7.29844  ? 208 ILE A CG1 1 
ATOM   1602 C  CG2 . ILE A 1 313 ? 21.09103 -21.55257 3.02220   1.000 6.82903  ? 208 ILE A CG2 1 
ATOM   1603 C  CD1 . ILE A 1 313 ? 20.07615 -24.51344 3.11188   1.000 9.09188  ? 208 ILE A CD1 1 
ATOM   1604 N  N   . LEU A 1 314 ? 24.52277 -22.12332 3.67025   1.000 7.26162  ? 209 LEU A N   1 
ATOM   1605 C  CA  . LEU A 1 314 ? 25.63658 -21.16178 3.63188   1.000 5.78368  ? 209 LEU A CA  1 
ATOM   1606 C  C   . LEU A 1 314 ? 25.18931 -19.94259 2.81986   1.000 6.71020  ? 209 LEU A C   1 
ATOM   1607 O  O   . LEU A 1 314 ? 24.67292 -20.09224 1.69861   1.000 8.05140  ? 209 LEU A O   1 
ATOM   1608 C  CB  . LEU A 1 314 ? 26.84562 -21.83495 2.95265   1.000 7.51629  ? 209 LEU A CB  1 
ATOM   1609 C  CG  . LEU A 1 314 ? 28.11697 -20.98420 2.76805   1.000 10.46636 ? 209 LEU A CG  1 
ATOM   1610 C  CD1 . LEU A 1 314 ? 28.63420 -20.59454 4.11957   1.000 14.88634 ? 209 LEU A CD1 1 
ATOM   1611 C  CD2 . LEU A 1 314 ? 29.08316 -21.85180 1.99010   1.000 13.42150 ? 209 LEU A CD2 1 
ATOM   1612 N  N   . SER A 1 315 ? 25.43936 -18.74889 3.36645   1.000 6.46111  ? 210 SER A N   1 
ATOM   1613 C  CA  . SER A 1 315 ? 25.09760 -17.51668 2.63489   1.000 5.27558  ? 210 SER A CA  1 
ATOM   1614 C  C   . SER A 1 315 ? 25.96527 -16.38622 3.17928   1.000 8.01169  ? 210 SER A C   1 
ATOM   1615 O  O   . SER A 1 315 ? 26.82981 -16.60233 4.04389   1.000 9.41655  ? 210 SER A O   1 
ATOM   1616 C  CB  . SER A 1 315 ? 23.58178 -17.24933 2.75131   1.000 6.39619  ? 210 SER A CB  1 
ATOM   1617 O  OG  . SER A 1 315 ? 23.26683 -16.17971 1.86250   1.000 6.79792  ? 210 SER A OG  1 
ATOM   1618 N  N   . THR A 1 316 ? 25.69506 -15.16361 2.70272   1.000 6.76465  ? 211 THR A N   1 
ATOM   1619 C  CA  . THR A 1 316 ? 26.36700 -13.96003 3.16157   1.000 6.17393  ? 211 THR A CA  1 
ATOM   1620 C  C   . THR A 1 316 ? 25.98941 -13.58661 4.58941   1.000 8.57865  ? 211 THR A C   1 
ATOM   1621 O  O   . THR A 1 316 ? 24.91470 -13.91918 5.08694   1.000 10.75940 ? 211 THR A O   1 
ATOM   1622 C  CB  . THR A 1 316 ? 25.98493 -12.79850 2.25237   1.000 9.06402  ? 211 THR A CB  1 
ATOM   1623 O  OG1 . THR A 1 316 ? 24.56451 -12.90111 1.97345   1.000 8.28678  ? 211 THR A OG1 1 
ATOM   1624 C  CG2 . THR A 1 316 ? 26.71164 -12.96572 0.90027   1.000 9.60499  ? 211 THR A CG2 1 
ATOM   1625 N  N   . TRP A 1 317 ? 26.91920 -12.88213 5.25426   1.000 6.86860  ? 212 TRP A N   1 
ATOM   1626 C  CA  . TRP A 1 317 ? 26.73052 -12.39102 6.61226   1.000 7.65877  ? 212 TRP A CA  1 
ATOM   1627 C  C   . TRP A 1 317 ? 27.38658 -11.01985 6.71592   1.000 8.41986  ? 212 TRP A C   1 
ATOM   1628 O  O   . TRP A 1 317 ? 28.11983 -10.60377 5.80176   1.000 9.53498  ? 212 TRP A O   1 
ATOM   1629 C  CB  . TRP A 1 317 ? 27.35088 -13.36107 7.63858   1.000 9.82256  ? 212 TRP A CB  1 
ATOM   1630 C  CG  . TRP A 1 317 ? 26.82252 -13.17344 9.07784   1.000 8.12408  ? 212 TRP A CG  1 
ATOM   1631 C  CD1 . TRP A 1 317 ? 27.47422 -12.56288 10.17235  1.000 9.33827  ? 212 TRP A CD1 1 
ATOM   1632 C  CD2 . TRP A 1 317 ? 25.56115 -13.61004 9.58317   1.000 9.01650  ? 212 TRP A CD2 1 
ATOM   1633 N  NE1 . TRP A 1 317 ? 26.66559 -12.60419 11.28156  1.000 9.32858  ? 212 TRP A NE1 1 
ATOM   1634 C  CE2 . TRP A 1 317 ? 25.50609 -13.26488 10.95522  1.000 8.36099  ? 212 TRP A CE2 1 
ATOM   1635 C  CE3 . TRP A 1 317 ? 24.46476 -14.29771 9.01645   1.000 8.40341  ? 212 TRP A CE3 1 
ATOM   1636 C  CZ2 . TRP A 1 317 ? 24.39856 -13.55990 11.76500  1.000 9.21622  ? 212 TRP A CZ2 1 
ATOM   1637 C  CZ3 . TRP A 1 317 ? 23.37595 -14.61352 9.84786   1.000 8.67877  ? 212 TRP A CZ3 1 
ATOM   1638 C  CH2 . TRP A 1 317 ? 23.34150 -14.21694 11.18898  1.000 11.42347 ? 212 TRP A CH2 1 
ATOM   1639 N  N   . ILE A 1 318 ? 27.04685 -10.30116 7.79488   1.000 7.13625  ? 213 ILE A N   1 
ATOM   1640 C  CA  . ILE A 1 318 ? 27.56266 -8.94146  7.96452   1.000 5.19904  ? 213 ILE A CA  1 
ATOM   1641 C  C   . ILE A 1 318 ? 29.08441 -8.96122  8.23790   1.000 9.83866  ? 213 ILE A C   1 
ATOM   1642 O  O   . ILE A 1 318 ? 29.70382 -9.98887  8.51674   1.000 11.95633 ? 213 ILE A O   1 
ATOM   1643 C  CB  . ILE A 1 318 ? 26.81657 -8.18426  9.05504   1.000 8.77897  ? 213 ILE A CB  1 
ATOM   1644 C  CG1 . ILE A 1 318 ? 26.81519 -8.92820  10.40667  1.000 13.76716 ? 213 ILE A CG1 1 
ATOM   1645 C  CG2 . ILE A 1 318 ? 25.37066 -7.90212  8.61831   1.000 11.50642 ? 213 ILE A CG2 1 
ATOM   1646 C  CD1 . ILE A 1 318 ? 26.27800 -8.04144  11.57321  1.000 13.77184 ? 213 ILE A CD1 1 
ATOM   1647 N  N   . GLY A 1 319 ? 29.68741 -7.79432  8.04684   1.000 9.61741  ? 214 GLY A N   1 
ATOM   1648 C  CA  . GLY A 1 319 ? 31.15153 -7.74150  8.07510   1.000 11.49540 ? 214 GLY A CA  1 
ATOM   1649 C  C   . GLY A 1 319 ? 31.81820 -8.34724  6.87454   1.000 11.85696 ? 214 GLY A C   1 
ATOM   1650 O  O   . GLY A 1 319 ? 33.00460 -8.71599  6.95377   1.000 14.13498 ? 214 GLY A O   1 
ATOM   1651 N  N   . GLY A 1 320 ? 31.12049 -8.42374  5.73336   1.000 8.29730  ? 215 GLY A N   1 
ATOM   1652 C  CA  . GLY A 1 320 ? 31.70024 -8.98635  4.53383   1.000 9.44855  ? 215 GLY A CA  1 
ATOM   1653 C  C   . GLY A 1 320 ? 32.02186 -10.46273 4.64903   1.000 12.33588 ? 215 GLY A C   1 
ATOM   1654 O  O   . GLY A 1 320 ? 32.93175 -10.95612 3.97263   1.000 14.14823 ? 215 GLY A O   1 
ATOM   1655 N  N   A SER A 1 321 ? 31.28414 -11.18747 5.49435   0.694 10.13894 ? 216 SER A N   1 
ATOM   1656 N  N   B SER A 1 321 ? 31.27103 -11.19209 5.46700   0.306 10.12412 ? 216 SER A N   1 
ATOM   1657 C  CA  A SER A 1 321 ? 31.61425 -12.56427 5.82223   0.694 8.27888  ? 216 SER A CA  1 
ATOM   1658 C  CA  B SER A 1 321 ? 31.60186 -12.56677 5.81192   0.306 8.34229  ? 216 SER A CA  1 
ATOM   1659 C  C   A SER A 1 321 ? 30.56711 -13.54583 5.22805   0.694 8.70462  ? 216 SER A C   1 
ATOM   1660 C  C   B SER A 1 321 ? 30.50978 -13.52988 5.30776   0.306 8.71717  ? 216 SER A C   1 
ATOM   1661 O  O   A SER A 1 321 ? 29.72067 -13.17952 4.37789   0.694 8.90305  ? 216 SER A O   1 
ATOM   1662 O  O   B SER A 1 321 ? 29.57139 -13.13365 4.60292   0.306 9.13861  ? 216 SER A O   1 
ATOM   1663 C  CB  A SER A 1 321 ? 31.74855 -12.70525 7.36892   0.694 10.10241 ? 216 SER A CB  1 
ATOM   1664 C  CB  B SER A 1 321 ? 31.80890 -12.67259 7.32952   0.306 10.13346 ? 216 SER A CB  1 
ATOM   1665 O  OG  A SER A 1 321 ? 30.52885 -12.51609 8.06703   0.694 9.48746  ? 216 SER A OG  1 
ATOM   1666 O  OG  B SER A 1 321 ? 32.40831 -13.90917 7.65953   0.306 8.31082  ? 216 SER A OG  1 
ATOM   1667 N  N   . THR A 1 322 ? 30.65648 -14.81407 5.66323   1.000 9.14785  ? 217 THR A N   1 
ATOM   1668 C  CA  . THR A 1 322 ? 29.68161 -15.85185 5.30782   1.000 6.83475  ? 217 THR A CA  1 
ATOM   1669 C  C   . THR A 1 322 ? 29.44440 -16.70495 6.53920   1.000 8.49861  ? 217 THR A C   1 
ATOM   1670 O  O   . THR A 1 322 ? 30.29127 -16.78043 7.43374   1.000 12.13358 ? 217 THR A O   1 
ATOM   1671 C  CB  . THR A 1 322 ? 30.13812 -16.74569 4.15723   1.000 10.02796 ? 217 THR A CB  1 
ATOM   1672 O  OG1 . THR A 1 322 ? 31.37011 -17.37360 4.57102   1.000 14.43461 ? 217 THR A OG1 1 
ATOM   1673 C  CG2 . THR A 1 322 ? 30.39086 -15.93478 2.86851   1.000 11.37569 ? 217 THR A CG2 1 
ATOM   1674 N  N   . ARG A 1 323 ? 28.27529 -17.33681 6.59963   1.000 8.07742  ? 218 ARG A N   1 
ATOM   1675 C  CA  . ARG A 1 323 ? 28.07612 -18.35099 7.62459   1.000 8.58905  ? 218 ARG A CA  1 
ATOM   1676 C  C   . ARG A 1 323 ? 26.89387 -19.23001 7.26851   1.000 8.40477  ? 218 ARG A C   1 
ATOM   1677 O  O   . ARG A 1 323 ? 26.11019 -18.92452 6.35832   1.000 7.69498  ? 218 ARG A O   1 
ATOM   1678 C  CB  . ARG A 1 323 ? 27.95768 -17.73337 9.01747   1.000 18.36238 ? 218 ARG A CB  1 
ATOM   1679 C  CG  . ARG A 1 323 ? 26.67300 -17.17443 9.37856   1.000 11.47592 ? 218 ARG A CG  1 
ATOM   1680 C  CD  . ARG A 1 323 ? 26.58973 -16.76130 10.91488  1.000 9.70520  ? 218 ARG A CD  1 
ATOM   1681 N  NE  . ARG A 1 323 ? 27.73402 -15.91579 11.26904  1.000 10.43585 ? 218 ARG A NE  1 
ATOM   1682 C  CZ  . ARG A 1 323 ? 27.95686 -15.41065 12.48280  1.000 9.39476  ? 218 ARG A CZ  1 
ATOM   1683 N  NH1 . ARG A 1 323 ? 27.16786 -15.68730 13.49422  1.000 12.25892 ? 218 ARG A NH1 1 
ATOM   1684 N  NH2 . ARG A 1 323 ? 29.05483 -14.68187 12.68744  1.000 11.25121 ? 218 ARG A NH2 1 
ATOM   1685 N  N   A SER A 1 324 ? 26.84153 -20.37865 7.92959   0.757 7.90830  ? 219 SER A N   1 
ATOM   1686 N  N   B SER A 1 324 ? 26.81219 -20.34835 7.96899   0.243 7.96901  ? 219 SER A N   1 
ATOM   1687 C  CA  A SER A 1 324 ? 25.79349 -21.38899 7.69004   0.757 7.60408  ? 219 SER A CA  1 
ATOM   1688 C  CA  B SER A 1 324 ? 25.71396 -21.28824 7.80837   0.243 7.78839  ? 219 SER A CA  1 
ATOM   1689 C  C   A SER A 1 324 ? 24.84817 -21.41566 8.88086   0.757 10.10934 ? 219 SER A C   1 
ATOM   1690 C  C   B SER A 1 324 ? 24.74586 -21.15005 8.97779   0.243 9.69001  ? 219 SER A C   1 
ATOM   1691 O  O   A SER A 1 324 ? 25.29006 -21.64130 10.01747  0.757 11.50694 ? 219 SER A O   1 
ATOM   1692 O  O   B SER A 1 324 ? 25.15338 -21.00692 10.13894  0.243 7.65346  ? 219 SER A O   1 
ATOM   1693 C  CB  A SER A 1 324 ? 26.42681 -22.76715 7.49818   0.757 12.81789 ? 219 SER A CB  1 
ATOM   1694 C  CB  B SER A 1 324 ? 26.24849 -22.71991 7.68017   0.243 11.47008 ? 219 SER A CB  1 
ATOM   1695 O  OG  A SER A 1 324 ? 25.45129 -23.77279 7.31212   0.757 16.24273 ? 219 SER A OG  1 
ATOM   1696 O  OG  B SER A 1 324 ? 27.17690 -22.82302 6.58845   0.243 5.99762  ? 219 SER A OG  1 
ATOM   1697 N  N   A ILE A 1 325 ? 23.54786 -21.22000 8.63869   0.757 7.64136  ? 220 ILE A N   1 
ATOM   1698 N  N   B ILE A 1 325 ? 23.45432 -21.14084 8.65186   0.243 7.71991  ? 220 ILE A N   1 
ATOM   1699 C  CA  A ILE A 1 325 ? 22.55168 -21.29346 9.70422   0.757 7.33616  ? 220 ILE A CA  1 
ATOM   1700 C  CA  B ILE A 1 325 ? 22.38754 -21.06008 9.64088   0.243 8.02172  ? 220 ILE A CA  1 
ATOM   1701 C  C   A ILE A 1 325 ? 21.32624 -22.02736 9.15681   0.757 7.48383  ? 220 ILE A C   1 
ATOM   1702 C  C   B ILE A 1 325 ? 21.22238 -21.88465 9.11986   0.243 7.59918  ? 220 ILE A C   1 
ATOM   1703 O  O   A ILE A 1 325 ? 21.25606 -22.37649 7.96353   0.757 7.51901  ? 220 ILE A O   1 
ATOM   1704 O  O   B ILE A 1 325 ? 21.13301 -22.19829 7.92496   0.243 7.38155  ? 220 ILE A O   1 
ATOM   1705 C  CB  A ILE A 1 325 ? 22.14324 -19.90143 10.27531  0.757 8.43478  ? 220 ILE A CB  1 
ATOM   1706 C  CB  B ILE A 1 325 ? 21.94406 -19.60039 9.94562   0.243 9.27366  ? 220 ILE A CB  1 
ATOM   1707 C  CG1 A ILE A 1 325 ? 21.68987 -18.93990 9.16019   0.757 10.65718 ? 220 ILE A CG1 1 
ATOM   1708 C  CG1 B ILE A 1 325 ? 20.88430 -19.54691 11.06265  0.243 9.64965  ? 220 ILE A CG1 1 
ATOM   1709 C  CG2 A ILE A 1 325 ? 23.27457 -19.16418 11.01359  0.757 9.26272  ? 220 ILE A CG2 1 
ATOM   1710 C  CG2 B ILE A 1 325 ? 21.42473 -18.93759 8.71328   0.243 12.06273 ? 220 ILE A CG2 1 
ATOM   1711 C  CD1 A ILE A 1 325 ? 20.94956 -17.56711 9.61499   0.757 7.72815  ? 220 ILE A CD1 1 
ATOM   1712 C  CD1 B ILE A 1 325 ? 20.69091 -18.19804 11.70735  0.243 19.11475 ? 220 ILE A CD1 1 
ATOM   1713 N  N   . SER A 1 326 ? 20.32617 -22.24965 10.03287  1.000 7.62459  ? 221 SER A N   1 
ATOM   1714 C  CA  . SER A 1 326 ? 19.19593 -23.11498 9.70752   1.000 7.54928  ? 221 SER A CA  1 
ATOM   1715 C  C   . SER A 1 326 ? 17.87979 -22.44369 10.10735  1.000 7.95082  ? 221 SER A C   1 
ATOM   1716 O  O   . SER A 1 326 ? 17.82180 -21.68524 11.07950  1.000 12.66428 ? 221 SER A O   1 
ATOM   1717 C  CB  . SER A 1 326 ? 19.27004 -24.47659 10.44771  1.000 9.12533  ? 221 SER A CB  1 
ATOM   1718 O  OG  . SER A 1 326 ? 20.49158 -25.17821 10.16880  1.000 9.35987  ? 221 SER A OG  1 
ATOM   1719 N  N   . GLY A 1 327 ? 16.85057 -22.69198 9.33027   1.000 7.10474  ? 222 GLY A N   1 
ATOM   1720 C  CA  . GLY A 1 327 ? 15.52477 -22.17178 9.65679   1.000 8.25363  ? 222 GLY A CA  1 
ATOM   1721 C  C   . GLY A 1 327 ? 14.60316 -22.23373 8.46434   1.000 6.07104  ? 222 GLY A C   1 
ATOM   1722 O  O   . GLY A 1 327 ? 15.03938 -22.34555 7.32263   1.000 7.52903  ? 222 GLY A O   1 
ATOM   1723 N  N   . THR A 1 328 ? 13.27269 -22.09506 8.72585   1.000 7.08317  ? 223 THR A N   1 
ATOM   1724 C  CA  . THR A 1 328 ? 12.38326 -21.83709 7.59354   1.000 6.67250  ? 223 THR A CA  1 
ATOM   1725 C  C   . THR A 1 328 ? 12.66592 -20.46694 7.00856   1.000 7.34605  ? 223 THR A C   1 
ATOM   1726 O  O   . THR A 1 328 ? 12.30626 -20.24478 5.85496   1.000 8.48388  ? 223 THR A O   1 
ATOM   1727 C  CB  . THR A 1 328 ? 10.85568 -21.93079 7.93715   1.000 5.71483  ? 223 THR A CB  1 
ATOM   1728 O  OG1 . THR A 1 328 ? 10.52409 -21.07453 9.02658   1.000 8.56014  ? 223 THR A OG1 1 
ATOM   1729 C  CG2 . THR A 1 328 ? 10.51446 -23.39022 8.31018   1.000 7.47151  ? 223 THR A CG2 1 
ATOM   1730 N  N   . SER A 1 329 ? 13.37551 -19.60382 7.76141   1.000 6.49293  ? 224 SER A N   1 
ATOM   1731 C  CA  . SER A 1 329 ? 13.84387 -18.32874 7.22476   1.000 5.53048  ? 224 SER A CA  1 
ATOM   1732 C  C   . SER A 1 329 ? 14.79129 -18.52672 6.06405   1.000 6.36804  ? 224 SER A C   1 
ATOM   1733 O  O   . SER A 1 329 ? 14.95174 -17.61734 5.24435   1.000 6.11684  ? 224 SER A O   1 
ATOM   1734 C  CB  . SER A 1 329 ? 14.62831 -17.54540 8.26813   1.000 10.58915 ? 224 SER A CB  1 
ATOM   1735 O  OG  . SER A 1 329 ? 13.80681 -17.02615 9.28959   1.000 13.51666 ? 224 SER A OG  1 
ATOM   1736 N  N   . MET A 1 330 ? 15.51218 -19.64895 6.03841   1.000 5.88884  ? 225 MET A N   1 
ATOM   1737 C  CA  . MET A 1 330 ? 16.44681 -19.95434 4.94712   1.000 5.92677  ? 225 MET A CA  1 
ATOM   1738 C  C   . MET A 1 330 ? 15.79598 -20.61736 3.76146   1.000 5.18712  ? 225 MET A C   1 
ATOM   1739 O  O   . MET A 1 330 ? 16.25549 -20.45494 2.63050   1.000 7.55102  ? 225 MET A O   1 
ATOM   1740 C  CB  . MET A 1 330 ? 17.65282 -20.84415 5.42047   1.000 8.11185  ? 225 MET A CB  1 
ATOM   1741 C  CG  . MET A 1 330 ? 18.66640 -20.22219 6.41602   1.000 9.25506  ? 225 MET A CG  1 
ATOM   1742 S  SD  . MET A 1 330 ? 18.05227 -19.54902 7.95688   1.000 9.09653  ? 225 MET A SD  1 
ATOM   1743 C  CE  . MET A 1 330 ? 18.08269 -17.78488 7.57553   1.000 10.80681 ? 225 MET A CE  1 
ATOM   1744 N  N   . ALA A 1 331 ? 14.70027 -21.33316 3.99049   1.000 6.85805  ? 226 ALA A N   1 
ATOM   1745 C  CA  . ALA A 1 331 ? 13.99323 -21.96522 2.90216   1.000 6.37011  ? 226 ALA A CA  1 
ATOM   1746 C  C   . ALA A 1 331 ? 13.23651 -20.92155 2.08879   1.000 5.50454  ? 226 ALA A C   1 
ATOM   1747 O  O   . ALA A 1 331 ? 13.18823 -21.02477 0.85213   1.000 7.06106  ? 226 ALA A O   1 
ATOM   1748 C  CB  . ALA A 1 331 ? 13.02389 -23.02456 3.47602   1.000 7.82051  ? 226 ALA A CB  1 
ATOM   1749 N  N   . THR A 1 332 ? 12.63664 -19.92832 2.76521   1.000 5.12319  ? 227 THR A N   1 
ATOM   1750 C  CA  . THR A 1 332 ? 11.79808 -18.92533 2.08125   1.000 3.41916  ? 227 THR A CA  1 
ATOM   1751 C  C   . THR A 1 332 ? 12.55101 -18.19603 0.95944   1.000 6.03421  ? 227 THR A C   1 
ATOM   1752 O  O   . THR A 1 332 ? 11.99491 -18.07780 -0.15015  1.000 6.14222  ? 227 THR A O   1 
ATOM   1753 C  CB  . THR A 1 332 ? 11.25667 -17.96313 3.13080   1.000 7.64955  ? 227 THR A CB  1 
ATOM   1754 O  OG1 . THR A 1 332 ? 10.47950 -18.73946 4.08679   1.000 6.94649  ? 227 THR A OG1 1 
ATOM   1755 C  CG2 . THR A 1 332 ? 10.37984 -16.83599 2.46442   1.000 8.45798  ? 227 THR A CG2 1 
ATOM   1756 N  N   . PRO A 1 333 ? 13.79121 -17.72920 1.14400   1.000 4.39739  ? 228 PRO A N   1 
ATOM   1757 C  CA  . PRO A 1 333 ? 14.46248 -17.03706 0.03223   1.000 5.27406  ? 228 PRO A CA  1 
ATOM   1758 C  C   . PRO A 1 333 ? 14.83913 -17.94428 -1.12651  1.000 5.95097  ? 228 PRO A C   1 
ATOM   1759 O  O   . PRO A 1 333 ? 15.01154 -17.43239 -2.23766  1.000 6.98128  ? 228 PRO A O   1 
ATOM   1760 C  CB  . PRO A 1 333 ? 15.72993 -16.42780 0.66070   1.000 7.37839  ? 228 PRO A CB  1 
ATOM   1761 C  CG  . PRO A 1 333 ? 15.89246 -17.14398 1.98367   1.000 7.81544  ? 228 PRO A CG  1 
ATOM   1762 C  CD  . PRO A 1 333 ? 14.47839 -17.53555 2.43080   1.000 5.31607  ? 228 PRO A CD  1 
ATOM   1763 N  N   . HIS A 1 334 ? 14.96264 -19.26002 -0.91318  1.000 5.29113  ? 229 HIS A N   1 
ATOM   1764 C  CA  . HIS A 1 334 ? 15.14682 -20.13091 -2.07321  1.000 5.74595  ? 229 HIS A CA  1 
ATOM   1765 C  C   . HIS A 1 334 ? 13.92636 -20.05454 -2.97055  1.000 7.21447  ? 229 HIS A C   1 
ATOM   1766 O  O   . HIS A 1 334 ? 14.05670 -20.03145 -4.20389  1.000 7.91056  ? 229 HIS A O   1 
ATOM   1767 C  CB  . HIS A 1 334 ? 15.35115 -21.59958 -1.64425  1.000 6.55604  ? 229 HIS A CB  1 
ATOM   1768 C  CG  . HIS A 1 334 ? 16.72268 -21.93172 -1.12247  1.000 6.07544  ? 229 HIS A CG  1 
ATOM   1769 N  ND1 . HIS A 1 334 ? 17.04165 -21.82535 0.21308   1.000 6.74929  ? 229 HIS A ND1 1 
ATOM   1770 C  CD2 . HIS A 1 334 ? 17.79957 -22.50136 -1.73566  1.000 8.17584  ? 229 HIS A CD2 1 
ATOM   1771 C  CE1 . HIS A 1 334 ? 18.29712 -22.23577 0.38912   1.000 9.11211  ? 229 HIS A CE1 1 
ATOM   1772 N  NE2 . HIS A 1 334 ? 18.79047 -22.64348 -0.77747  1.000 8.95680  ? 229 HIS A NE2 1 
ATOM   1773 N  N   . VAL A 1 335 ? 12.71261 -20.04461 -2.34767  1.000 5.68658  ? 230 VAL A N   1 
ATOM   1774 C  CA  . VAL A 1 335 ? 11.47522 -20.00486 -3.13359  1.000 6.42341  ? 230 VAL A CA  1 
ATOM   1775 C  C   . VAL A 1 335 ? 11.27007 -18.61948 -3.72844  1.000 7.72594  ? 230 VAL A C   1 
ATOM   1776 O  O   . VAL A 1 335 ? 10.87923 -18.49743 -4.89895  1.000 8.01990  ? 230 VAL A O   1 
ATOM   1777 C  CB  . VAL A 1 335 ? 10.29346 -20.48170 -2.26451  1.000 4.97990  ? 230 VAL A CB  1 
ATOM   1778 C  CG1 . VAL A 1 335 ? 8.94268  -20.15928 -2.91572  1.000 7.83206  ? 230 VAL A CG1 1 
ATOM   1779 C  CG2 . VAL A 1 335 ? 10.44368 -21.99569 -2.01629  1.000 8.37597  ? 230 VAL A CG2 1 
ATOM   1780 N  N   . ALA A 1 336 ? 11.57910 -17.54713 -2.97019  1.000 6.28233  ? 231 ALA A N   1 
ATOM   1781 C  CA  . ALA A 1 336 ? 11.46666 -16.18284 -3.53138  1.000 4.28373  ? 231 ALA A CA  1 
ATOM   1782 C  C   . ALA A 1 336 ? 12.41480 -15.97939 -4.71267  1.000 7.28279  ? 231 ALA A C   1 
ATOM   1783 O  O   . ALA A 1 336 ? 12.03106 -15.41438 -5.74566  1.000 6.58002  ? 231 ALA A O   1 
ATOM   1784 C  CB  . ALA A 1 336 ? 11.80570 -15.16382 -2.43657  1.000 5.91770  ? 231 ALA A CB  1 
ATOM   1785 N  N   . GLY A 1 337 ? 13.65233 -16.44898 -4.58684  1.000 6.23368  ? 232 GLY A N   1 
ATOM   1786 C  CA  . GLY A 1 337 ? 14.58282 -16.38415 -5.70738  1.000 6.42944  ? 232 GLY A CA  1 
ATOM   1787 C  C   . GLY A 1 337 ? 14.11611 -17.22093 -6.88885  1.000 6.71014  ? 232 GLY A C   1 
ATOM   1788 O  O   . GLY A 1 337 ? 14.31805 -16.81592 -8.03498  1.000 8.43572  ? 232 GLY A O   1 
ATOM   1789 N  N   . LEU A 1 338 ? 13.61668 -18.43580 -6.63117  1.000 6.01630  ? 233 LEU A N   1 
ATOM   1790 C  CA  . LEU A 1 338 ? 13.11754 -19.26216 -7.75181  1.000 6.54389  ? 233 LEU A CA  1 
ATOM   1791 C  C   . LEU A 1 338 ? 11.96821 -18.56143 -8.46215  1.000 7.94969  ? 233 LEU A C   1 
ATOM   1792 O  O   . LEU A 1 338 ? 11.87940 -18.57833 -9.70561  1.000 7.72770  ? 233 LEU A O   1 
ATOM   1793 C  CB  . LEU A 1 338 ? 12.69431 -20.63332 -7.21451  1.000 7.72112  ? 233 LEU A CB  1 
ATOM   1794 C  CG  . LEU A 1 338 ? 12.09193 -21.59035 -8.23580  1.000 10.09662 ? 233 LEU A CG  1 
ATOM   1795 C  CD1 . LEU A 1 338 ? 13.17593 -21.87396 -9.35405  1.000 11.22643 ? 233 LEU A CD1 1 
ATOM   1796 C  CD2 . LEU A 1 338 ? 11.62836 -22.88674 -7.58267  1.000 10.74558 ? 233 LEU A CD2 1 
ATOM   1797 N  N   . ALA A 1 339 ? 11.06912 -17.91774 -7.70486  1.000 7.13792  ? 234 ALA A N   1 
ATOM   1798 C  CA  . ALA A 1 339 ? 9.99969  -17.18772 -8.37223  1.000 5.94660  ? 234 ALA A CA  1 
ATOM   1799 C  C   . ALA A 1 339 ? 10.54660 -16.09008 -9.28980  1.000 8.41862  ? 234 ALA A C   1 
ATOM   1800 O  O   . ALA A 1 339 ? 10.06311 -15.90925 -10.42390 1.000 9.03204  ? 234 ALA A O   1 
ATOM   1801 C  CB  . ALA A 1 339 ? 9.00829  -16.62616 -7.33512  1.000 7.18863  ? 234 ALA A CB  1 
ATOM   1802 N  N   . ALA A 1 340 ? 11.49119 -15.27312 -8.78922  1.000 6.29810  ? 235 ALA A N   1 
ATOM   1803 C  CA  . ALA A 1 340 ? 12.07670 -14.22091 -9.62936  1.000 6.31905  ? 235 ALA A CA  1 
ATOM   1804 C  C   . ALA A 1 340 ? 12.69938 -14.81048 -10.88797 1.000 9.53969  ? 235 ALA A C   1 
ATOM   1805 O  O   . ALA A 1 340 ? 12.52812 -14.26944 -11.98516 1.000 9.76147  ? 235 ALA A O   1 
ATOM   1806 C  CB  . ALA A 1 340 ? 13.14197 -13.41787 -8.84062  1.000 8.76581  ? 235 ALA A CB  1 
ATOM   1807 N  N   . TYR A 1 341 ? 13.41658 -15.92422 -10.72827 1.000 7.73485  ? 236 TYR A N   1 
ATOM   1808 C  CA  . TYR A 1 341 ? 14.04582 -16.61827 -11.84595 1.000 6.60136  ? 236 TYR A CA  1 
ATOM   1809 C  C   . TYR A 1 341 ? 13.00601 -17.06656 -12.87618 1.000 8.82697  ? 236 TYR A C   1 
ATOM   1810 O  O   . TYR A 1 341 ? 13.19153 -16.86428 -14.09072 1.000 9.15232  ? 236 TYR A O   1 
ATOM   1811 C  CB  . TYR A 1 341 ? 14.83162 -17.81129 -11.28136 1.000 7.14472  ? 236 TYR A CB  1 
ATOM   1812 C  CG  . TYR A 1 341 ? 15.34436 -18.82918 -12.31290 1.000 6.29047  ? 236 TYR A CG  1 
ATOM   1813 C  CD1 . TYR A 1 341 ? 16.60562 -18.64878 -12.88755 1.000 10.54107 ? 236 TYR A CD1 1 
ATOM   1814 C  CD2 . TYR A 1 341 ? 14.61988 -19.94344 -12.62722 1.000 8.35838  ? 236 TYR A CD2 1 
ATOM   1815 C  CE1 . TYR A 1 341 ? 17.07132 -19.57288 -13.78873 1.000 9.57857  ? 236 TYR A CE1 1 
ATOM   1816 C  CE2 . TYR A 1 341 ? 15.09048 -20.89343 -13.50437 1.000 9.41832  ? 236 TYR A CE2 1 
ATOM   1817 C  CZ  . TYR A 1 341 ? 16.33078 -20.71696 -14.05306 1.000 11.54589 ? 236 TYR A CZ  1 
ATOM   1818 O  OH  . TYR A 1 341 ? 16.75109 -21.69781 -14.92104 1.000 11.48126 ? 236 TYR A OH  1 
ATOM   1819 N  N   . LEU A 1 342 ? 11.89981 -17.65096 -12.40034 1.000 6.50993  ? 237 LEU A N   1 
ATOM   1820 C  CA  . LEU A 1 342 ? 10.89871 -18.14037 -13.35232 1.000 6.75986  ? 237 LEU A CA  1 
ATOM   1821 C  C   . LEU A 1 342 ? 10.10800 -16.99238 -13.99123 1.000 9.91816  ? 237 LEU A C   1 
ATOM   1822 O  O   . LEU A 1 342 ? 9.68080  -17.10257 -15.16929 1.000 10.52043 ? 237 LEU A O   1 
ATOM   1823 C  CB  . LEU A 1 342 ? 9.92778  -19.08302 -12.63907 1.000 8.34457  ? 237 LEU A CB  1 
ATOM   1824 C  CG  . LEU A 1 342 ? 10.57896 -20.36528 -12.12655 1.000 9.36730  ? 237 LEU A CG  1 
ATOM   1825 C  CD1 . LEU A 1 342 ? 9.63076  -21.12155 -11.14999 1.000 10.45424 ? 237 LEU A CD1 1 
ATOM   1826 C  CD2 . LEU A 1 342 ? 10.96925 -21.29658 -13.30377 1.000 11.98901 ? 237 LEU A CD2 1 
ATOM   1827 N  N   A MET A 1 343 ? 9.87521  -15.88811 -13.26561 0.486 8.50196  ? 238 MET A N   1 
ATOM   1828 N  N   B MET A 1 343 ? 9.87628  -15.90758 -13.26098 0.514 8.48648  ? 238 MET A N   1 
ATOM   1829 C  CA  A MET A 1 343 ? 9.19529  -14.72861 -13.87252 0.486 7.45588  ? 238 MET A CA  1 
ATOM   1830 C  CA  B MET A 1 343 ? 9.20906  -14.76082 -13.87672 0.514 7.45853  ? 238 MET A CA  1 
ATOM   1831 C  C   A MET A 1 343 ? 10.04586 -14.06744 -14.96124 0.486 9.56330  ? 238 MET A C   1 
ATOM   1832 C  C   B MET A 1 343 ? 10.05272 -14.18916 -15.00858 0.514 9.51226  ? 238 MET A C   1 
ATOM   1833 O  O   A MET A 1 343 ? 9.50701  -13.56317 -15.96505 0.486 9.60781  ? 238 MET A O   1 
ATOM   1834 O  O   B MET A 1 343 ? 9.52632  -13.90999 -16.10214 0.514 8.88079  ? 238 MET A O   1 
ATOM   1835 C  CB  A MET A 1 343 ? 8.82227  -13.70443 -12.77139 0.486 9.72478  ? 238 MET A CB  1 
ATOM   1836 C  CB  B MET A 1 343 ? 8.93442  -13.71903 -12.78087 0.514 9.71281  ? 238 MET A CB  1 
ATOM   1837 C  CG  A MET A 1 343 ? 7.60345  -14.17643 -11.89575 0.486 10.03936 ? 238 MET A CG  1 
ATOM   1838 C  CG  B MET A 1 343 ? 7.88472  -14.32448 -11.82897 0.514 9.71200  ? 238 MET A CG  1 
ATOM   1839 S  SD  A MET A 1 343 ? 7.65972  -13.62727 -10.11421 0.486 16.07310 ? 238 MET A SD  1 
ATOM   1840 S  SD  B MET A 1 343 ? 7.51996  -13.28873 -10.35699 0.514 22.02133 ? 238 MET A SD  1 
ATOM   1841 C  CE  A MET A 1 343 ? 7.70243  -11.87464 -10.47467 0.486 10.29759 ? 238 MET A CE  1 
ATOM   1842 C  CE  B MET A 1 343 ? 6.63621  -12.06411 -11.13660 0.514 11.32654 ? 238 MET A CE  1 
ATOM   1843 N  N   . THR A 1 344 ? 11.37306 -14.02068 -14.77700 1.000 7.89697  ? 239 THR A N   1 
ATOM   1844 C  CA  . THR A 1 344 ? 12.23999 -13.50890 -15.82267 1.000 7.53862  ? 239 THR A CA  1 
ATOM   1845 C  C   . THR A 1 344 ? 12.21606 -14.39513 -17.07829 1.000 8.93634  ? 239 THR A C   1 
ATOM   1846 O  O   . THR A 1 344 ? 12.28954 -13.86242 -18.21648 1.000 12.05768 ? 239 THR A O   1 
ATOM   1847 C  CB  . THR A 1 344 ? 13.66809 -13.42549 -15.26498 1.000 9.72435  ? 239 THR A CB  1 
ATOM   1848 O  OG1 . THR A 1 344 ? 13.72555 -12.35169 -14.33879 1.000 12.04762 ? 239 THR A OG1 1 
ATOM   1849 C  CG2 . THR A 1 344 ? 14.71193 -13.22447 -16.36318 1.000 12.27325 ? 239 THR A CG2 1 
ATOM   1850 N  N   . LEU A 1 345 ? 12.08890 -15.71947 -16.91473 1.000 9.77702  ? 240 LEU A N   1 
ATOM   1851 C  CA  . LEU A 1 345 ? 11.97427 -16.64590 -18.04449 1.000 9.42176  ? 240 LEU A CA  1 
ATOM   1852 C  C   . LEU A 1 345 ? 10.60668 -16.59588 -18.70146 1.000 13.49608 ? 240 LEU A C   1 
ATOM   1853 O  O   . LEU A 1 345 ? 10.42382 -17.22057 -19.75949 1.000 17.12491 ? 240 LEU A O   1 
ATOM   1854 C  CB  . LEU A 1 345 ? 12.22653 -18.07522 -17.58726 1.000 10.40649 ? 240 LEU A CB  1 
ATOM   1855 C  CG  . LEU A 1 345 ? 13.71283 -18.38440 -17.36429 1.000 16.83793 ? 240 LEU A CG  1 
ATOM   1856 C  CD1 . LEU A 1 345 ? 13.86591 -19.77665 -16.85833 1.000 18.36555 ? 240 LEU A CD1 1 
ATOM   1857 C  CD2 . LEU A 1 345 ? 14.47167 -18.24612 -18.66925 1.000 20.49217 ? 240 LEU A CD2 1 
ATOM   1858 N  N   . GLY A 1 346 ? 9.66417  -15.90277 -18.09374 1.000 9.59312  ? 241 GLY A N   1 
ATOM   1859 C  CA  . GLY A 1 346 ? 8.30775  -15.81097 -18.65045 1.000 9.69880  ? 241 GLY A CA  1 
ATOM   1860 C  C   . GLY A 1 346 ? 7.39696  -16.98909 -18.40768 1.000 10.92817 ? 241 GLY A C   1 
ATOM   1861 O  O   . GLY A 1 346 ? 6.36936  -17.11823 -19.09612 1.000 13.99144 ? 241 GLY A O   1 
ATOM   1862 N  N   . LYS A 1 347 ? 7.74493  -17.88184 -17.49327 1.000 10.68998 ? 242 LYS A N   1 
ATOM   1863 C  CA  . LYS A 1 347 ? 7.00024  -19.10357 -17.30383 1.000 8.10452  ? 242 LYS A CA  1 
ATOM   1864 C  C   . LYS A 1 347 ? 5.78089  -18.86451 -16.44746 1.000 9.71600  ? 242 LYS A C   1 
ATOM   1865 O  O   . LYS A 1 347 ? 4.85704  -19.69640 -16.47060 1.000 12.72544 ? 242 LYS A O   1 
ATOM   1866 C  CB  . LYS A 1 347 ? 7.88493  -20.18140 -16.65705 1.000 13.66790 ? 242 LYS A CB  1 
ATOM   1867 C  CG  . LYS A 1 347 ? 9.04901  -20.59024 -17.58900 1.000 20.39099 ? 242 LYS A CG  1 
ATOM   1868 C  CD  . LYS A 1 347 ? 9.39580  -22.05250 -17.48271 1.000 37.77901 ? 242 LYS A CD  1 
ATOM   1869 C  CE  . LYS A 1 347 ? 10.86670 -22.34434 -17.81816 1.000 51.95618 ? 242 LYS A CE  1 
ATOM   1870 N  NZ  . LYS A 1 347 ? 11.48109 -23.43595 -16.94506 1.000 53.37597 ? 242 LYS A NZ  1 
ATOM   1871 N  N   . THR A 1 348 ? 5.79125  -17.78662 -15.65957 1.000 10.93025 ? 243 THR A N   1 
ATOM   1872 C  CA  . THR A 1 348 ? 4.69142  -17.55079 -14.72880 1.000 10.40822 ? 243 THR A CA  1 
ATOM   1873 C  C   . THR A 1 348 ? 4.67521  -16.06550 -14.37776 1.000 11.84023 ? 243 THR A C   1 
ATOM   1874 O  O   . THR A 1 348 ? 5.51590  -15.28319 -14.83547 1.000 13.28022 ? 243 THR A O   1 
ATOM   1875 C  CB  . THR A 1 348 ? 4.84439  -18.43869 -13.49049 1.000 13.71257 ? 243 THR A CB  1 
ATOM   1876 O  OG1 . THR A 1 348 ? 3.66246  -18.38431 -12.66790 1.000 11.21697 ? 243 THR A OG1 1 
ATOM   1877 C  CG2 . THR A 1 348 ? 6.07786  -18.05763 -12.61109 1.000 11.12700 ? 243 THR A CG2 1 
ATOM   1878 N  N   . THR A 1 349 ? 3.66990  -15.66685 -13.61023 1.000 10.75008 ? 244 THR A N   1 
ATOM   1879 C  CA  . THR A 1 349 ? 3.46718  -14.27676 -13.18769 1.000 11.43361 ? 244 THR A CA  1 
ATOM   1880 C  C   . THR A 1 349 ? 3.42849  -14.25082 -11.67200 1.000 10.66716 ? 244 THR A C   1 
ATOM   1881 O  O   . THR A 1 349 ? 3.38465  -15.29469 -11.03730 1.000 10.33169 ? 244 THR A O   1 
ATOM   1882 C  CB  . THR A 1 349 ? 2.13966  -13.70880 -13.69743 1.000 13.63527 ? 244 THR A CB  1 
ATOM   1883 O  OG1 . THR A 1 349 ? 1.08571  -14.47226 -13.07622 1.000 16.35105 ? 244 THR A OG1 1 
ATOM   1884 C  CG2 . THR A 1 349 ? 2.05955  -13.92352 -15.18733 1.000 18.49433 ? 244 THR A CG2 1 
ATOM   1885 N  N   . ALA A 1 350 ? 3.42900  -13.03873 -11.10143 1.000 10.84294 ? 245 ALA A N   1 
ATOM   1886 C  CA  . ALA A 1 350 ? 3.37857  -12.93190 -9.63169  1.000 8.65828  ? 245 ALA A CA  1 
ATOM   1887 C  C   . ALA A 1 350 ? 2.13263  -13.56924 -9.05954  1.000 13.28029 ? 245 ALA A C   1 
ATOM   1888 O  O   . ALA A 1 350 ? 2.18253  -14.16687 -7.96502  1.000 13.78257 ? 245 ALA A O   1 
ATOM   1889 C  CB  . ALA A 1 350 ? 3.44972  -11.46218 -9.18852  1.000 10.55047 ? 245 ALA A CB  1 
ATOM   1890 N  N   . ALA A 1 351 ? 0.98511  -13.44586 -9.75313  1.000 9.24110  ? 246 ALA A N   1 
ATOM   1891 C  CA  . ALA A 1 351 ? -0.24126 -13.99783 -9.21269  1.000 12.44798 ? 246 ALA A CA  1 
ATOM   1892 C  C   . ALA A 1 351 ? -0.25320 -15.51145 -9.16186  1.000 12.76840 ? 246 ALA A C   1 
ATOM   1893 O  O   . ALA A 1 351 ? -0.89625 -16.08414 -8.28402  1.000 15.45478 ? 246 ALA A O   1 
ATOM   1894 C  CB  . ALA A 1 351 ? -1.47300 -13.52785 -10.01368 1.000 12.72093 ? 246 ALA A CB  1 
ATOM   1895 N  N   A SER A 1 352 ? 0.46063  -16.17641 -10.06203 0.603 8.31855  ? 247 SER A N   1 
ATOM   1896 N  N   B SER A 1 352 ? 0.43713  -16.18434 -10.08947 0.397 8.36856  ? 247 SER A N   1 
ATOM   1897 C  CA  A SER A 1 352 ? 0.34400  -17.61561 -10.17455 0.603 9.95739  ? 247 SER A CA  1 
ATOM   1898 C  CA  B SER A 1 352 ? 0.36179  -17.63372 -10.20645 0.397 10.01049 ? 247 SER A CA  1 
ATOM   1899 C  C   A SER A 1 352 ? 1.65574  -18.34257 -9.91814  0.603 10.73750 ? 247 SER A C   1 
ATOM   1900 C  C   B SER A 1 352 ? 1.62078  -18.36448 -9.77145  0.397 10.84051 ? 247 SER A C   1 
ATOM   1901 O  O   A SER A 1 352 ? 1.71333  -19.54990 -10.12687 0.603 8.92667  ? 247 SER A O   1 
ATOM   1902 O  O   B SER A 1 352 ? 1.60292  -19.59860 -9.72189  0.397 9.36539  ? 247 SER A O   1 
ATOM   1903 C  CB  A SER A 1 352 ? -0.17832 -17.99176 -11.58005 0.603 12.00030 ? 247 SER A CB  1 
ATOM   1904 C  CB  B SER A 1 352 ? 0.06536  -18.05191 -11.66850 0.397 11.29651 ? 247 SER A CB  1 
ATOM   1905 O  OG  A SER A 1 352 ? 0.67406  -17.50083 -12.59707 0.603 13.32314 ? 247 SER A OG  1 
ATOM   1906 O  OG  B SER A 1 352 ? -0.82468 -17.15914 -12.29906 0.397 15.15679 ? 247 SER A OG  1 
ATOM   1907 N  N   . ALA A 1 353 ? 2.70274  -17.64582 -9.45550  1.000 8.57998  ? 248 ALA A N   1 
ATOM   1908 C  CA  . ALA A 1 353 ? 3.99508  -18.30672 -9.32111  1.000 7.01607  ? 248 ALA A CA  1 
ATOM   1909 C  C   . ALA A 1 353 ? 3.98808  -19.39685 -8.25418  1.000 8.67836  ? 248 ALA A C   1 
ATOM   1910 O  O   . ALA A 1 353 ? 4.62904  -20.42300 -8.41391  1.000 8.07364  ? 248 ALA A O   1 
ATOM   1911 C  CB  . ALA A 1 353 ? 5.05327  -17.22691 -9.04735  1.000 9.73626  ? 248 ALA A CB  1 
ATOM   1912 N  N   . CYS A 1 354 ? 3.29307  -19.18381 -7.12198  1.000 6.43678  ? 249 CYS A N   1 
ATOM   1913 C  CA  . CYS A 1 354 ? 3.33467  -20.20303 -6.07737  1.000 7.31658  ? 249 CYS A CA  1 
ATOM   1914 C  C   . CYS A 1 354 ? 2.71274  -21.49769 -6.59355  1.000 11.25670 ? 249 CYS A C   1 
ATOM   1915 O  O   . CYS A 1 354 ? 3.25221  -22.59884 -6.37348  1.000 10.10402 ? 249 CYS A O   1 
ATOM   1916 C  CB  . CYS A 1 354 ? 2.59540  -19.66271 -4.84020  1.000 7.17016  ? 249 CYS A CB  1 
ATOM   1917 S  SG  . CYS A 1 354 ? 2.75666  -20.75325 -3.36714  1.000 9.14803  ? 249 CYS A SG  1 
ATOM   1918 N  N   A ARG A 1 355 ? 1.57024  -21.37783 -7.28116  0.510 8.56672  ? 250 ARG A N   1 
ATOM   1919 N  N   B ARG A 1 355 ? 1.57431  -21.36882 -7.28868  0.490 8.57517  ? 250 ARG A N   1 
ATOM   1920 C  CA  A ARG A 1 355 ? 0.92936  -22.55133 -7.86855  0.510 9.59930  ? 250 ARG A CA  1 
ATOM   1921 C  CA  B ARG A 1 355 ? 0.90662  -22.52154 -7.88831  0.490 9.63133  ? 250 ARG A CA  1 
ATOM   1922 C  C   A ARG A 1 355 ? 1.81042  -23.19353 -8.93564  0.510 8.81061  ? 250 ARG A C   1 
ATOM   1923 C  C   B ARG A 1 355 ? 1.77564  -23.18172 -8.95769  0.490 8.80614  ? 250 ARG A C   1 
ATOM   1924 O  O   A ARG A 1 355 ? 1.91811  -24.42065 -8.97625  0.510 11.48996 ? 250 ARG A O   1 
ATOM   1925 O  O   B ARG A 1 355 ? 1.86270  -24.41078 -9.00243  0.490 11.50331 ? 250 ARG A O   1 
ATOM   1926 C  CB  A ARG A 1 355 ? -0.44008 -22.15944 -8.44376  0.510 14.15024 ? 250 ARG A CB  1 
ATOM   1927 C  CB  B ARG A 1 355 ? -0.46870 -22.07291 -8.43087  0.490 14.11562 ? 250 ARG A CB  1 
ATOM   1928 C  CG  A ARG A 1 355 ? -1.16922 -23.35375 -9.06642  0.510 18.61878 ? 250 ARG A CG  1 
ATOM   1929 C  CG  B ARG A 1 355 ? -1.16915 -23.11701 -9.29677  0.490 19.01908 ? 250 ARG A CG  1 
ATOM   1930 C  CD  A ARG A 1 355 ? -2.26356 -23.92217 -8.16680  0.510 37.03898 ? 250 ARG A CD  1 
ATOM   1931 C  CD  B ARG A 1 355 ? -2.32569 -22.55683 -10.15615 0.490 13.94834 ? 250 ARG A CD  1 
ATOM   1932 N  NE  A ARG A 1 355 ? -1.80483 -24.18464 -6.80984  0.510 34.84423 ? 250 ARG A NE  1 
ATOM   1933 N  NE  B ARG A 1 355 ? -3.34979 -21.86181 -9.39711  0.490 32.52648 ? 250 ARG A NE  1 
ATOM   1934 C  CZ  A ARG A 1 355 ? -1.16159 -25.28064 -6.43624  0.510 28.89916 ? 250 ARG A CZ  1 
ATOM   1935 C  CZ  B ARG A 1 355 ? -4.43891 -22.45069 -8.92013  0.490 32.03170 ? 250 ARG A CZ  1 
ATOM   1936 N  NH1 A ARG A 1 355 ? -0.90501 -26.25790 -7.28870  0.510 18.63225 ? 250 ARG A NH1 1 
ATOM   1937 N  NH1 B ARG A 1 355 ? -4.58689 -23.76201 -8.95385  0.490 41.78967 ? 250 ARG A NH1 1 
ATOM   1938 N  NH2 A ARG A 1 355 ? -0.77497 -25.40035 -5.17105  0.510 27.50616 ? 250 ARG A NH2 1 
ATOM   1939 N  NH2 B ARG A 1 355 ? -5.39775 -21.70566 -8.38339  0.490 40.77196 ? 250 ARG A NH2 1 
ATOM   1940 N  N   . TYR A 1 356 ? 2.45935  -22.39074 -9.78332  1.000 9.28136  ? 251 TYR A N   1 
ATOM   1941 C  CA  . TYR A 1 356 ? 3.37238  -22.93941 -10.79565 1.000 8.27548  ? 251 TYR A CA  1 
ATOM   1942 C  C   . TYR A 1 356 ? 4.52423  -23.69881 -10.13529 1.000 10.72855 ? 251 TYR A C   1 
ATOM   1943 O  O   . TYR A 1 356 ? 4.90624  -24.77156 -10.59826 1.000 9.55513  ? 251 TYR A O   1 
ATOM   1944 C  CB  . TYR A 1 356 ? 3.91582  -21.80627 -11.69857 1.000 10.00745 ? 251 TYR A CB  1 
ATOM   1945 C  CG  . TYR A 1 356 ? 4.85026  -22.28014 -12.79167 1.000 6.63728  ? 251 TYR A CG  1 
ATOM   1946 C  CD1 . TYR A 1 356 ? 4.35027  -22.68858 -13.99710 1.000 11.40050 ? 251 TYR A CD1 1 
ATOM   1947 C  CD2 . TYR A 1 356 ? 6.20957  -22.38266 -12.58100 1.000 9.66688  ? 251 TYR A CD2 1 
ATOM   1948 C  CE1 . TYR A 1 356 ? 5.18331  -23.17163 -15.00587 1.000 14.76492 ? 251 TYR A CE1 1 
ATOM   1949 C  CE2 . TYR A 1 356 ? 7.05895  -22.84724 -13.58403 1.000 11.73145 ? 251 TYR A CE2 1 
ATOM   1950 C  CZ  . TYR A 1 356 ? 6.51455  -23.26124 -14.79024 1.000 14.47964 ? 251 TYR A CZ  1 
ATOM   1951 O  OH  . TYR A 1 356 ? 7.35569  -23.73523 -15.78516 1.000 14.76330 ? 251 TYR A OH  1 
ATOM   1952 N  N   . ILE A 1 357 ? 5.12484  -23.11512 -9.07615  1.000 8.38992  ? 252 ILE A N   1 
ATOM   1953 C  CA  . ILE A 1 357 ? 6.20250  -23.80388 -8.36201  1.000 7.24746  ? 252 ILE A CA  1 
ATOM   1954 C  C   . ILE A 1 357 ? 5.70628  -25.14208 -7.78625  1.000 8.51544  ? 252 ILE A C   1 
ATOM   1955 O  O   . ILE A 1 357 ? 6.40057  -26.18011 -7.90200  1.000 9.78470  ? 252 ILE A O   1 
ATOM   1956 C  CB  . ILE A 1 357 ? 6.79916  -22.85815 -7.29015  1.000 8.37457  ? 252 ILE A CB  1 
ATOM   1957 C  CG1 . ILE A 1 357 ? 7.57813  -21.75116 -7.98903  1.000 8.84996  ? 252 ILE A CG1 1 
ATOM   1958 C  CG2 . ILE A 1 357 ? 7.67710  -23.61620 -6.29136  1.000 8.96053  ? 252 ILE A CG2 1 
ATOM   1959 C  CD1 . ILE A 1 357 ? 7.99291  -20.57448 -7.09197  1.000 11.46796 ? 252 ILE A CD1 1 
ATOM   1960 N  N   . ALA A 1 358 ? 4.47910  -25.16677 -7.19301  1.000 7.73497  ? 253 ALA A N   1 
ATOM   1961 C  CA  . ALA A 1 358 ? 3.92085  -26.41473 -6.65656  1.000 8.02436  ? 253 ALA A CA  1 
ATOM   1962 C  C   . ALA A 1 358 ? 3.67050  -27.42332 -7.77844  1.000 10.74174 ? 253 ALA A C   1 
ATOM   1963 O  O   . ALA A 1 358 ? 3.93163  -28.63347 -7.60004  1.000 11.64443 ? 253 ALA A O   1 
ATOM   1964 C  CB  . ALA A 1 358 ? 2.60714  -26.13204 -5.88357  1.000 10.24086 ? 253 ALA A CB  1 
ATOM   1965 N  N   . ASP A 1 359 ? 3.15163  -26.94952 -8.93142  1.000 9.20506  ? 254 ASP A N   1 
ATOM   1966 C  CA  . ASP A 1 359 ? 2.79324  -27.85991 -10.02919 1.000 9.81504  ? 254 ASP A CA  1 
ATOM   1967 C  C   . ASP A 1 359 ? 4.02365  -28.53636 -10.60653 1.000 11.27566 ? 254 ASP A C   1 
ATOM   1968 O  O   . ASP A 1 359 ? 3.92348  -29.68619 -11.11794 1.000 14.47395 ? 254 ASP A O   1 
ATOM   1969 C  CB  . ASP A 1 359 ? 2.15180  -27.11883 -11.16795 1.000 11.74251 ? 254 ASP A CB  1 
ATOM   1970 C  CG  . ASP A 1 359 ? 0.65866  -26.77817 -10.94240 1.000 18.73827 ? 254 ASP A CG  1 
ATOM   1971 O  OD1 . ASP A 1 359 ? 0.04536  -27.28972 -10.01342 1.000 24.35531 ? 254 ASP A OD1 1 
ATOM   1972 O  OD2 . ASP A 1 359 ? 0.20012  -25.97258 -11.75081 1.000 24.77575 ? 254 ASP A OD2 1 
ATOM   1973 N  N   . THR A 1 360 ? 5.15998  -27.82101 -10.61205 1.000 9.39935  ? 255 THR A N   1 
ATOM   1974 C  CA  . THR A 1 360 ? 6.39008  -28.29955 -11.25615 1.000 10.28618 ? 255 THR A CA  1 
ATOM   1975 C  C   . THR A 1 360 ? 7.41572  -28.83154 -10.25226 1.000 9.76677  ? 255 THR A C   1 
ATOM   1976 O  O   . THR A 1 360 ? 8.56819  -29.12188 -10.64623 1.000 10.97977 ? 255 THR A O   1 
ATOM   1977 C  CB  . THR A 1 360 ? 7.03744  -27.18726 -12.11131 1.000 12.34708 ? 255 THR A CB  1 
ATOM   1978 O  OG1 . THR A 1 360 ? 7.33385  -26.01225 -11.30797 1.000 10.36230 ? 255 THR A OG1 1 
ATOM   1979 C  CG2 . THR A 1 360 ? 6.09919  -26.72994 -13.24624 1.000 13.63281 ? 255 THR A CG2 1 
ATOM   1980 N  N   . ALA A 1 361 ? 7.03638  -28.93519 -8.97726  1.000 8.49347  ? 256 ALA A N   1 
ATOM   1981 C  CA  . ALA A 1 361 ? 7.92949  -29.39088 -7.90478  1.000 7.06490  ? 256 ALA A CA  1 
ATOM   1982 C  C   . ALA A 1 361 ? 8.32576  -30.85996 -8.06773  1.000 11.13447 ? 256 ALA A C   1 
ATOM   1983 O  O   . ALA A 1 361 ? 7.61878  -31.66068 -8.71022  1.000 12.88734 ? 256 ALA A O   1 
ATOM   1984 C  CB  . ALA A 1 361 ? 7.22501  -29.24644 -6.57594  1.000 10.39915 ? 256 ALA A CB  1 
ATOM   1985 N  N   . ASN A 1 362 ? 9.40437  -31.23920 -7.37945  1.000 9.07048  ? 257 ASN A N   1 
ATOM   1986 C  CA  . ASN A 1 362 ? 9.63455  -32.66708 -7.15450  1.000 11.05315 ? 257 ASN A CA  1 
ATOM   1987 C  C   . ASN A 1 362 ? 8.61402  -33.18940 -6.14831  1.000 12.79402 ? 257 ASN A C   1 
ATOM   1988 O  O   . ASN A 1 362 ? 8.45205  -32.62554 -5.05733  1.000 11.22993 ? 257 ASN A O   1 
ATOM   1989 C  CB  . ASN A 1 362 ? 11.05324 -32.89982 -6.64539  1.000 10.19027 ? 257 ASN A CB  1 
ATOM   1990 C  CG  . ASN A 1 362 ? 12.08389 -32.88367 -7.76690  1.000 15.24280 ? 257 ASN A CG  1 
ATOM   1991 O  OD1 . ASN A 1 362 ? 11.89870 -33.55907 -8.80811  1.000 15.63349 ? 257 ASN A OD1 1 
ATOM   1992 N  ND2 . ASN A 1 362 ? 13.13647 -32.06265 -7.61271  1.000 13.94017 ? 257 ASN A ND2 1 
ATOM   1993 N  N   . LYS A 1 363 ? 7.88300  -34.26645 -6.51091  1.000 10.79729 ? 258 LYS A N   1 
ATOM   1994 C  CA  . LYS A 1 363 ? 6.73973  -34.71335 -5.69219  1.000 11.75327 ? 258 LYS A CA  1 
ATOM   1995 C  C   . LYS A 1 363 ? 7.04935  -36.05259 -5.02161  1.000 11.28854 ? 258 LYS A C   1 
ATOM   1996 O  O   . LYS A 1 363 ? 7.57024  -36.96445 -5.67266  1.000 16.01855 ? 258 LYS A O   1 
ATOM   1997 C  CB  . LYS A 1 363 ? 5.47116  -34.85211 -6.57898  1.000 16.02724 ? 258 LYS A CB  1 
ATOM   1998 C  CG  . LYS A 1 363 ? 5.33985  -33.81229 -7.67004  1.000 27.82700 ? 258 LYS A CG  1 
ATOM   1999 C  CD  . LYS A 1 363 ? 3.87819  -33.57112 -8.06577  1.000 33.57761 ? 258 LYS A CD  1 
ATOM   2000 C  CE  . LYS A 1 363 ? 3.69404  -32.38216 -9.05228  1.000 39.17520 ? 258 LYS A CE  1 
ATOM   2001 N  NZ  . LYS A 1 363 ? 4.90968  -32.00923 -9.88343  1.000 30.20710 ? 258 LYS A NZ  1 
ATOM   2002 N  N   . GLY A 1 364 ? 6.76222  -36.15370 -3.72935  1.000 11.31751 ? 259 GLY A N   1 
ATOM   2003 C  CA  . GLY A 1 364 ? 6.84710  -37.40033 -2.97249  1.000 13.23430 ? 259 GLY A CA  1 
ATOM   2004 C  C   . GLY A 1 364 ? 8.23621  -37.79859 -2.52668  1.000 19.48667 ? 259 GLY A C   1 
ATOM   2005 O  O   . GLY A 1 364 ? 8.40452  -38.90777 -2.01682  1.000 19.61541 ? 259 GLY A O   1 
ATOM   2006 N  N   . ASP A 1 365 ? 9.23797  -36.93681 -2.69224  1.000 13.82440 ? 260 ASP A N   1 
ATOM   2007 C  CA  . ASP A 1 365 ? 10.61892 -37.28226 -2.34023  1.000 14.17614 ? 260 ASP A CA  1 
ATOM   2008 C  C   . ASP A 1 365 ? 10.98459 -37.02360 -0.87470  1.000 14.09537 ? 260 ASP A C   1 
ATOM   2009 O  O   . ASP A 1 365 ? 12.03178 -37.51369 -0.40936  1.000 16.94546 ? 260 ASP A O   1 
ATOM   2010 C  CB  . ASP A 1 365 ? 11.56821 -36.53335 -3.26764  1.000 16.12462 ? 260 ASP A CB  1 
ATOM   2011 C  CG  . ASP A 1 365 ? 11.41658 -36.97396 -4.74287  1.000 24.96675 ? 260 ASP A CG  1 
ATOM   2012 O  OD1 . ASP A 1 365 ? 11.13547 -38.16375 -4.97996  1.000 31.29268 ? 260 ASP A OD1 1 
ATOM   2013 O  OD2 . ASP A 1 365 ? 11.54207 -36.13182 -5.65223  1.000 32.23991 ? 260 ASP A OD2 1 
ATOM   2014 N  N   . LEU A 1 366 ? 10.18831 -36.27334 -0.10398  1.000 10.39990 ? 261 LEU A N   1 
ATOM   2015 C  CA  . LEU A 1 366 ? 10.57443 -35.92422 1.25160   1.000 11.17684 ? 261 LEU A CA  1 
ATOM   2016 C  C   . LEU A 1 366 ? 10.07590 -36.96869 2.24821   1.000 12.73455 ? 261 LEU A C   1 
ATOM   2017 O  O   . LEU A 1 366 ? 9.01769  -37.60451 2.04872   1.000 15.58061 ? 261 LEU A O   1 
ATOM   2018 C  CB  . LEU A 1 366 ? 10.00361 -34.54596 1.62536   1.000 10.40042 ? 261 LEU A CB  1 
ATOM   2019 C  CG  . LEU A 1 366 ? 10.56903 -33.45484 0.75471   1.000 10.84590 ? 261 LEU A CG  1 
ATOM   2020 C  CD1 . LEU A 1 366 ? 9.74328  -32.17873 1.12770   1.000 14.80304 ? 261 LEU A CD1 1 
ATOM   2021 C  CD2 . LEU A 1 366 ? 12.10440 -33.28868 1.09150   1.000 15.35938 ? 261 LEU A CD2 1 
ATOM   2022 N  N   A SER A 1 367 ? 10.86427 -37.20906 3.28926   0.542 11.03129 ? 262 SER A N   1 
ATOM   2023 N  N   B SER A 1 367 ? 10.83778 -37.12731 3.33394   0.458 11.04960 ? 262 SER A N   1 
ATOM   2024 C  CA  A SER A 1 367 ? 10.42766 -38.08128 4.36544   0.542 12.32562 ? 262 SER A CA  1 
ATOM   2025 C  CA  B SER A 1 367 ? 10.49946 -37.97083 4.46976   0.458 12.19964 ? 262 SER A CA  1 
ATOM   2026 C  C   A SER A 1 367 ? 10.05386 -37.23663 5.57109   0.542 12.41443 ? 262 SER A C   1 
ATOM   2027 C  C   B SER A 1 367 ? 10.07551 -37.13055 5.67056   0.458 12.88457 ? 262 SER A C   1 
ATOM   2028 O  O   A SER A 1 367 ? 10.40424 -36.05086 5.64412   0.542 14.13371 ? 262 SER A O   1 
ATOM   2029 O  O   B SER A 1 367 ? 10.31711 -35.91960 5.72342   0.458 13.83272 ? 262 SER A O   1 
ATOM   2030 C  CB  A SER A 1 367 ? 11.51159 -39.09069 4.75689   0.542 14.63746 ? 262 SER A CB  1 
ATOM   2031 C  CB  B SER A 1 367 ? 11.68702 -38.86147 4.85150   0.458 14.50842 ? 262 SER A CB  1 
ATOM   2032 O  OG  A SER A 1 367 ? 12.61583 -38.42276 5.31636   0.542 16.76414 ? 262 SER A OG  1 
ATOM   2033 O  OG  B SER A 1 367 ? 11.94005 -39.80354 3.82401   0.458 21.73185 ? 262 SER A OG  1 
ATOM   2034 N  N   A ASN A 1 368 ? 9.31224  -37.86028 6.50611   0.542 12.25158 ? 263 ASN A N   1 
ATOM   2035 N  N   B ASN A 1 368 ? 9.44003  -37.80335 6.64481   0.458 12.35373 ? 263 ASN A N   1 
ATOM   2036 C  CA  A ASN A 1 368 ? 8.87718  -37.26577 7.77839   0.542 11.42980 ? 263 ASN A CA  1 
ATOM   2037 C  CA  B ASN A 1 368 ? 8.85055  -37.19949 7.85217   0.458 11.46952 ? 263 ASN A CA  1 
ATOM   2038 C  C   A ASN A 1 368 ? 7.85387  -36.13134 7.59222   0.542 11.63264 ? 263 ASN A C   1 
ATOM   2039 C  C   B ASN A 1 368 ? 7.93025  -36.02714 7.50400   0.458 11.51918 ? 263 ASN A C   1 
ATOM   2040 O  O   A ASN A 1 368 ? 7.78985  -35.20016 8.40512   0.542 12.79772 ? 263 ASN A O   1 
ATOM   2041 O  O   B ASN A 1 368 ? 8.02975  -34.93809 8.07350   0.458 12.65469 ? 263 ASN A O   1 
ATOM   2042 C  CB  A ASN A 1 368 ? 10.07066 -36.81392 8.63090   0.542 16.24375 ? 263 ASN A CB  1 
ATOM   2043 C  CB  B ASN A 1 368 ? 9.90986  -36.75883 8.86260   0.458 16.14466 ? 263 ASN A CB  1 
ATOM   2044 C  CG  A ASN A 1 368 ? 11.09551 -37.95163 8.85547   0.542 14.19745 ? 263 ASN A CG  1 
ATOM   2045 C  CG  B ASN A 1 368 ? 9.33247  -36.55699 10.28484  0.458 17.00848 ? 263 ASN A CG  1 
ATOM   2046 O  OD1 A ASN A 1 368 ? 10.77324 -39.12703 8.67267   0.542 16.28310 ? 263 ASN A OD1 1 
ATOM   2047 O  OD1 B ASN A 1 368 ? 8.31950  -37.18055 10.66356  0.458 26.61939 ? 263 ASN A OD1 1 
ATOM   2048 N  ND2 A ASN A 1 368 ? 12.32663 -37.59390 9.28092   0.542 15.01515 ? 263 ASN A ND2 1 
ATOM   2049 N  ND2 B ASN A 1 368 ? 9.98360  -35.71926 11.07267  0.458 25.53682 ? 263 ASN A ND2 1 
ATOM   2050 N  N   . ILE A 1 369 ? 7.03441  -36.26460 6.56143   1.000 13.38064 ? 264 ILE A N   1 
ATOM   2051 C  CA  . ILE A 1 369 ? 5.96405  -35.32382 6.23240   1.000 11.21070 ? 264 ILE A CA  1 
ATOM   2052 C  C   . ILE A 1 369 ? 4.66026  -35.86321 6.82149   1.000 14.23534 ? 264 ILE A C   1 
ATOM   2053 O  O   . ILE A 1 369 ? 4.23766  -36.96771 6.43316   1.000 15.31202 ? 264 ILE A O   1 
ATOM   2054 C  CB  . ILE A 1 369 ? 5.84597  -35.16236 4.71078   1.000 15.19158 ? 264 ILE A CB  1 
ATOM   2055 C  CG1 . ILE A 1 369 ? 7.18160  -34.66993 4.09429   1.000 17.46556 ? 264 ILE A CG1 1 
ATOM   2056 C  CG2 . ILE A 1 369 ? 4.66283  -34.22311 4.35589   1.000 15.96757 ? 264 ILE A CG2 1 
ATOM   2057 C  CD1 . ILE A 1 369 ? 7.46424  -33.23760 4.44682   1.000 16.64185 ? 264 ILE A CD1 1 
ATOM   2058 N  N   . PRO A 1 370 ? 4.02427  -35.15761 7.76731   1.000 14.31588 ? 265 PRO A N   1 
ATOM   2059 C  CA  . PRO A 1 370 ? 2.76372  -35.64723 8.36871   1.000 12.86227 ? 265 PRO A CA  1 
ATOM   2060 C  C   . PRO A 1 370 ? 1.64812  -35.70040 7.35723   1.000 19.28566 ? 265 PRO A C   1 
ATOM   2061 O  O   . PRO A 1 370 ? 1.60857  -34.92383 6.41104   1.000 16.20660 ? 265 PRO A O   1 
ATOM   2062 C  CB  . PRO A 1 370 ? 2.45752  -34.60369 9.44724   1.000 19.77352 ? 265 PRO A CB  1 
ATOM   2063 C  CG  . PRO A 1 370 ? 3.71273  -33.84813 9.65242   1.000 22.09515 ? 265 PRO A CG  1 
ATOM   2064 C  CD  . PRO A 1 370 ? 4.35429  -33.82255 8.30830   1.000 14.60370 ? 265 PRO A CD  1 
ATOM   2065 N  N   A PHE A 1 371 ? 0.75456  -36.68611 7.51392   0.597 17.20751 ? 266 PHE A N   1 
ATOM   2066 N  N   B PHE A 1 371 ? 0.70699  -36.62027 7.59633   0.403 17.08819 ? 266 PHE A N   1 
ATOM   2067 C  CA  A PHE A 1 371 ? -0.39152 -36.77246 6.61327   0.597 16.05602 ? 266 PHE A CA  1 
ATOM   2068 C  CA  B PHE A 1 371 ? -0.47628 -36.72827 6.75378   0.403 16.53069 ? 266 PHE A CA  1 
ATOM   2069 C  C   A PHE A 1 371 ? -1.16735 -35.45011 6.62299   0.597 13.64528 ? 266 PHE A C   1 
ATOM   2070 C  C   B PHE A 1 371 ? -1.17638 -35.37755 6.65553   0.403 13.64389 ? 266 PHE A C   1 
ATOM   2071 O  O   A PHE A 1 371 ? -1.42912 -34.87927 7.67281   0.597 18.69567 ? 266 PHE A O   1 
ATOM   2072 O  O   B PHE A 1 371 ? -1.41207 -34.72136 7.66541   0.403 18.83451 ? 266 PHE A O   1 
ATOM   2073 C  CB  A PHE A 1 371 ? -1.29908 -37.97106 7.01388   0.597 16.27801 ? 266 PHE A CB  1 
ATOM   2074 C  CB  B PHE A 1 371 ? -1.43159 -37.79070 7.33813   0.403 16.37361 ? 266 PHE A CB  1 
ATOM   2075 C  CG  A PHE A 1 371 ? -2.30839 -38.34180 5.95406   0.597 11.94325 ? 266 PHE A CG  1 
ATOM   2076 C  CG  B PHE A 1 371 ? -2.84846 -37.66799 6.84590   0.403 14.45805 ? 266 PHE A CG  1 
ATOM   2077 C  CD1 A PHE A 1 371 ? -1.98036 -39.14617 4.89606   0.597 17.72409 ? 266 PHE A CD1 1 
ATOM   2078 C  CD1 B PHE A 1 371 ? -3.22128 -38.25510 5.63369   0.403 17.21642 ? 266 PHE A CD1 1 
ATOM   2079 C  CD2 A PHE A 1 371 ? -3.61092 -37.79172 6.03113   0.597 18.06949 ? 266 PHE A CD2 1 
ATOM   2080 C  CD2 B PHE A 1 371 ? -3.81010 -36.99119 7.58972   0.403 15.35073 ? 266 PHE A CD2 1 
ATOM   2081 C  CE1 A PHE A 1 371 ? -2.93010 -39.42922 3.89880   0.597 17.72034 ? 266 PHE A CE1 1 
ATOM   2082 C  CE1 B PHE A 1 371 ? -4.52924 -38.11934 5.14757   0.403 16.16241 ? 266 PHE A CE1 1 
ATOM   2083 C  CE2 A PHE A 1 371 ? -4.56950 -38.04218 5.03422   0.597 15.82737 ? 266 PHE A CE2 1 
ATOM   2084 C  CE2 B PHE A 1 371 ? -5.10623 -36.86714 7.11857   0.403 19.97075 ? 266 PHE A CE2 1 
ATOM   2085 C  CZ  A PHE A 1 371 ? -4.22976 -38.85589 3.98184   0.597 17.78317 ? 266 PHE A CZ  1 
ATOM   2086 C  CZ  B PHE A 1 371 ? -5.46681 -37.43728 5.89838   0.403 15.93112 ? 266 PHE A CZ  1 
ATOM   2087 N  N   . GLY A 1 372 ? -1.50728 -34.95906 5.42821   1.000 16.45007 ? 267 GLY A N   1 
ATOM   2088 C  CA  . GLY A 1 372 ? -2.21798 -33.69703 5.27266   1.000 16.94477 ? 267 GLY A CA  1 
ATOM   2089 C  C   . GLY A 1 372 ? -1.32705 -32.52021 4.89447   1.000 17.18352 ? 267 GLY A C   1 
ATOM   2090 O  O   . GLY A 1 372 ? -1.83462 -31.42432 4.57190   1.000 18.51108 ? 267 GLY A O   1 
ATOM   2091 N  N   . THR A 1 373 ? -0.02539 -32.70862 4.95027   1.000 11.17056 ? 268 THR A N   1 
ATOM   2092 C  CA  . THR A 1 373 ? 0.92182  -31.69655 4.46276   1.000 9.93213  ? 268 THR A CA  1 
ATOM   2093 C  C   . THR A 1 373 ? 1.44953  -32.10127 3.08386   1.000 12.07439 ? 268 THR A C   1 
ATOM   2094 O  O   . THR A 1 373 ? 1.64317  -33.29645 2.79386   1.000 12.91277 ? 268 THR A O   1 
ATOM   2095 C  CB  . THR A 1 373 ? 2.06128  -31.59388 5.48142   1.000 11.69162 ? 268 THR A CB  1 
ATOM   2096 O  OG1 . THR A 1 373 ? 1.58504  -31.18793 6.75748   1.000 13.53813 ? 268 THR A OG1 1 
ATOM   2097 C  CG2 . THR A 1 373 ? 3.16887  -30.60471 5.01489   1.000 12.49220 ? 268 THR A CG2 1 
ATOM   2098 N  N   . VAL A 1 374 ? 1.62051  -31.10878 2.19207   1.000 10.01435 ? 269 VAL A N   1 
ATOM   2099 C  CA  . VAL A 1 374 ? 2.11894  -31.41637 0.85066   1.000 10.21568 ? 269 VAL A CA  1 
ATOM   2100 C  C   . VAL A 1 374 ? 3.52562  -32.00935 0.90626   1.000 10.98873 ? 269 VAL A C   1 
ATOM   2101 O  O   . VAL A 1 374 ? 4.34091  -31.68255 1.77484   1.000 14.60144 ? 269 VAL A O   1 
ATOM   2102 C  CB  . VAL A 1 374 ? 2.12017  -30.18638 -0.07732  1.000 12.58259 ? 269 VAL A CB  1 
ATOM   2103 C  CG1 . VAL A 1 374 ? 0.70803  -29.73078 -0.38975  1.000 18.47461 ? 269 VAL A CG1 1 
ATOM   2104 C  CG2 . VAL A 1 374 ? 2.98250  -29.05746 0.46019   1.000 11.02983 ? 269 VAL A CG2 1 
ATOM   2105 N  N   . ASN A 1 375 ? 3.79854  -32.90762 -0.02693  1.000 8.57470  ? 270 ASN A N   1 
ATOM   2106 C  CA  . ASN A 1 375 ? 5.15184  -33.44616 -0.16756  1.000 8.51407  ? 270 ASN A CA  1 
ATOM   2107 C  C   . ASN A 1 375 ? 5.68661  -32.93855 -1.49401  1.000 10.08420 ? 270 ASN A C   1 
ATOM   2108 O  O   . ASN A 1 375 ? 5.67430  -33.63395 -2.50927  1.000 10.78421 ? 270 ASN A O   1 
ATOM   2109 C  CB  . ASN A 1 375 ? 5.11646  -35.01038 -0.08736  1.000 10.05538 ? 270 ASN A CB  1 
ATOM   2110 C  CG  . ASN A 1 375 ? 6.48380  -35.60525 0.06501   1.000 12.71855 ? 270 ASN A CG  1 
ATOM   2111 O  OD1 . ASN A 1 375 ? 7.45577  -35.06060 -0.44345  1.000 12.72737 ? 270 ASN A OD1 1 
ATOM   2112 N  ND2 . ASN A 1 375 ? 6.57031  -36.74910 0.76894   1.000 15.85468 ? 270 ASN A ND2 1 
ATOM   2113 N  N   . LEU A 1 376 ? 6.12576  -31.66154 -1.49718  1.000 8.21229  ? 271 LEU A N   1 
ATOM   2114 C  CA  . LEU A 1 376 ? 6.54225  -30.96557 -2.71006  1.000 7.71510  ? 271 LEU A CA  1 
ATOM   2115 C  C   . LEU A 1 376 ? 7.80574  -30.17586 -2.38854  1.000 9.62802  ? 271 LEU A C   1 
ATOM   2116 O  O   . LEU A 1 376 ? 7.82720  -29.41522 -1.40333  1.000 9.58772  ? 271 LEU A O   1 
ATOM   2117 C  CB  . LEU A 1 376 ? 5.48455  -29.96085 -3.17519  1.000 8.64403  ? 271 LEU A CB  1 
ATOM   2118 C  CG  . LEU A 1 376 ? 4.11924  -30.59828 -3.48406  1.000 10.84312 ? 271 LEU A CG  1 
ATOM   2119 C  CD1 . LEU A 1 376 ? 3.13018  -29.42576 -3.73349  1.000 12.69380 ? 271 LEU A CD1 1 
ATOM   2120 C  CD2 . LEU A 1 376 ? 4.25728  -31.41318 -4.77524  1.000 14.06884 ? 271 LEU A CD2 1 
ATOM   2121 N  N   . LEU A 1 377 ? 8.83003  -30.32798 -3.23123  1.000 7.53329  ? 272 LEU A N   1 
ATOM   2122 C  CA  . LEU A 1 377 ? 10.13807 -29.69398 -3.03128  1.000 7.77000  ? 272 LEU A CA  1 
ATOM   2123 C  C   . LEU A 1 377 ? 10.42454 -28.82838 -4.25167  1.000 8.46909  ? 272 LEU A C   1 
ATOM   2124 O  O   . LEU A 1 377 ? 10.38568 -29.32028 -5.37484  1.000 9.70848  ? 272 LEU A O   1 
ATOM   2125 C  CB  . LEU A 1 377 ? 11.23822 -30.76649 -2.86022  1.000 11.66861 ? 272 LEU A CB  1 
ATOM   2126 C  CG  . LEU A 1 377 ? 12.68537 -30.26509 -2.61351  1.000 11.05036 ? 272 LEU A CG  1 
ATOM   2127 C  CD1 . LEU A 1 377 ? 12.76759 -29.48804 -1.30061  1.000 12.58197 ? 272 LEU A CD1 1 
ATOM   2128 C  CD2 . LEU A 1 377 ? 13.61971 -31.52460 -2.57194  1.000 12.48149 ? 272 LEU A CD2 1 
ATOM   2129 N  N   . ALA A 1 378 ? 10.72941 -27.54610 -4.03078  1.000 6.66435  ? 273 ALA A N   1 
ATOM   2130 C  CA  . ALA A 1 378 ? 10.93312 -26.58756 -5.11436  1.000 7.98532  ? 273 ALA A CA  1 
ATOM   2131 C  C   . ALA A 1 378 ? 11.99345 -27.09057 -6.09377  1.000 9.48841  ? 273 ALA A C   1 
ATOM   2132 O  O   . ALA A 1 378 ? 13.03984 -27.59436 -5.67963  1.000 10.22688 ? 273 ALA A O   1 
ATOM   2133 C  CB  . ALA A 1 378 ? 11.40968 -25.24946 -4.49631  1.000 9.86843  ? 273 ALA A CB  1 
ATOM   2134 N  N   . TYR A 1 379 ? 11.75033 -26.87328 -7.38638  1.000 7.95386  ? 274 TYR A N   1 
ATOM   2135 C  CA  . TYR A 1 379 ? 12.57129 -27.45670 -8.46556  1.000 8.58588  ? 274 TYR A CA  1 
ATOM   2136 C  C   . TYR A 1 379 ? 12.50800 -26.54736 -9.68925  1.000 11.93835 ? 274 TYR A C   1 
ATOM   2137 O  O   . TYR A 1 379 ? 11.41667 -26.08403 -10.06941 1.000 11.68557 ? 274 TYR A O   1 
ATOM   2138 C  CB  . TYR A 1 379 ? 12.03413 -28.85995 -8.80493  1.000 7.57443  ? 274 TYR A CB  1 
ATOM   2139 C  CG  . TYR A 1 379 ? 12.75694 -29.55567 -9.98676  1.000 8.62362  ? 274 TYR A CG  1 
ATOM   2140 C  CD1 . TYR A 1 379 ? 14.13549 -29.63435 -10.01042 1.000 12.08514 ? 274 TYR A CD1 1 
ATOM   2141 C  CD2 . TYR A 1 379 ? 12.03831 -30.13317 -11.02660 1.000 15.40696 ? 274 TYR A CD2 1 
ATOM   2142 C  CE1 . TYR A 1 379 ? 14.77152 -30.27993 -11.04094 1.000 10.81100 ? 274 TYR A CE1 1 
ATOM   2143 C  CE2 . TYR A 1 379 ? 12.66280 -30.77336 -12.05344 1.000 15.58450 ? 274 TYR A CE2 1 
ATOM   2144 C  CZ  . TYR A 1 379 ? 14.01596 -30.82483 -12.08446 1.000 13.47076 ? 274 TYR A CZ  1 
ATOM   2145 O  OH  . TYR A 1 379 ? 14.64348 -31.46417 -13.19293 1.000 14.95453 ? 274 TYR A OH  1 
ATOM   2146 N  N   . ASN A 1 380 ? 13.66448 -26.26268 -10.31043 1.000 8.50576  ? 275 ASN A N   1 
ATOM   2147 C  CA  . ASN A 1 380 ? 13.66635 -25.26898 -11.39170 1.000 6.53404  ? 275 ASN A CA  1 
ATOM   2148 C  C   . ASN A 1 380 ? 13.49369 -25.87096 -12.77999 1.000 10.44210 ? 275 ASN A C   1 
ATOM   2149 O  O   . ASN A 1 380 ? 13.36192 -25.11017 -13.73448 1.000 10.75580 ? 275 ASN A O   1 
ATOM   2150 C  CB  . ASN A 1 380 ? 14.94416 -24.36692 -11.31024 1.000 8.03152  ? 275 ASN A CB  1 
ATOM   2151 C  CG  . ASN A 1 380 ? 16.23400 -25.07392 -11.73414 1.000 8.97116  ? 275 ASN A CG  1 
ATOM   2152 O  OD1 . ASN A 1 380 ? 16.23315 -26.24991 -12.05918 1.000 10.31903 ? 275 ASN A OD1 1 
ATOM   2153 N  ND2 . ASN A 1 380 ? 17.32628 -24.28408 -11.78264 1.000 11.27477 ? 275 ASN A ND2 1 
ATOM   2154 N  N   A ASN A 1 381 ? 13.51446 -27.20830 -12.88761 0.470 13.15019 ? 276 ASN A N   1 
ATOM   2155 N  N   B ASN A 1 381 ? 13.40770 -27.19273 -12.89731 0.530 13.16077 ? 276 ASN A N   1 
ATOM   2156 C  CA  A ASN A 1 381 ? 13.21494 -27.95082 -14.12243 0.470 12.18298 ? 276 ASN A CA  1 
ATOM   2157 C  CA  B ASN A 1 381 ? 13.15557 -27.81469 -14.20408 0.530 12.22286 ? 276 ASN A CA  1 
ATOM   2158 C  C   A ASN A 1 381 ? 14.18947 -27.65869 -15.26360 0.470 12.93856 ? 276 ASN A C   1 
ATOM   2159 C  C   B ASN A 1 381 ? 14.09991 -27.30197 -15.28902 0.530 12.19999 ? 276 ASN A C   1 
ATOM   2160 O  O   A ASN A 1 381 ? 13.87441 -27.91156 -16.43241 0.470 11.32382 ? 276 ASN A O   1 
ATOM   2161 O  O   B ASN A 1 381 ? 13.69117 -27.04483 -16.43533 0.530 12.89562 ? 276 ASN A O   1 
ATOM   2162 C  CB  A ASN A 1 381 ? 11.77804 -27.66558 -14.56698 0.470 13.43783 ? 276 ASN A CB  1 
ATOM   2163 C  CB  B ASN A 1 381 ? 11.70903 -27.59646 -14.64351 0.530 13.29744 ? 276 ASN A CB  1 
ATOM   2164 C  CG  A ASN A 1 381 ? 10.78019 -28.42845 -13.73610 0.470 13.75828 ? 276 ASN A CG  1 
ATOM   2165 C  CG  B ASN A 1 381 ? 11.11019 -28.84429 -15.18808 0.530 23.14555 ? 276 ASN A CG  1 
ATOM   2166 O  OD1 A ASN A 1 381 ? 10.22725 -27.89622 -12.78123 0.470 18.39802 ? 276 ASN A OD1 1 
ATOM   2167 O  OD1 B ASN A 1 381 ? 11.50329 -29.30824 -16.24256 0.530 29.19218 ? 276 ASN A OD1 1 
ATOM   2168 N  ND2 A ASN A 1 381 ? 10.56715 -29.69030 -14.07679 0.470 17.34818 ? 276 ASN A ND2 1 
ATOM   2169 N  ND2 B ASN A 1 381 ? 10.19579 -29.43995 -14.43678 0.530 25.10731 ? 276 ASN A ND2 1 
ATOM   2170 N  N   . TYR A 1 382 ? 15.37973 -27.15287 -14.95226 1.000 13.23827 ? 277 TYR A N   1 
ATOM   2171 C  CA  . TYR A 1 382 ? 16.31485 -26.69965 -15.96517 1.000 12.81293 ? 277 TYR A CA  1 
ATOM   2172 C  C   . TYR A 1 382 ? 16.75482 -27.84705 -16.86043 1.000 15.72500 ? 277 TYR A C   1 
ATOM   2173 O  O   . TYR A 1 382 ? 17.10990 -28.91701 -16.38005 1.000 22.17595 ? 277 TYR A O   1 
ATOM   2174 C  CB  . TYR A 1 382 ? 17.51770 -26.06094 -15.28729 1.000 15.02301 ? 277 TYR A CB  1 
ATOM   2175 C  CG  . TYR A 1 382 ? 18.57921 -25.58272 -16.27504 1.000 16.64156 ? 277 TYR A CG  1 
ATOM   2176 C  CD1 . TYR A 1 382 ? 18.34966 -24.45498 -17.05573 1.000 22.72257 ? 277 TYR A CD1 1 
ATOM   2177 C  CD2 . TYR A 1 382 ? 19.72345 -26.31879 -16.46204 1.000 19.93298 ? 277 TYR A CD2 1 
ATOM   2178 C  CE1 . TYR A 1 382 ? 19.30023 -24.00747 -17.97171 1.000 25.70195 ? 277 TYR A CE1 1 
ATOM   2179 C  CE2 . TYR A 1 382 ? 20.68950 -25.89937 -17.38814 1.000 17.74728 ? 277 TYR A CE2 1 
ATOM   2180 C  CZ  . TYR A 1 382 ? 20.46255 -24.73622 -18.10803 1.000 18.69375 ? 277 TYR A CZ  1 
ATOM   2181 O  OH  . TYR A 1 382 ? 21.42385 -24.30884 -19.03093 1.000 26.28622 ? 277 TYR A OH  1 
ATOM   2182 N  N   A GLN A 1 383 ? 16.70816 -27.60490 -18.16436 0.407 18.61991 ? 278 GLN A N   1 
ATOM   2183 N  N   B GLN A 1 383 ? 16.75163 -27.58970 -18.15992 0.593 18.47979 ? 278 GLN A N   1 
ATOM   2184 C  CA  A GLN A 1 383 ? 17.19542 -28.54447 -19.16597 0.407 30.90977 ? 278 GLN A CA  1 
ATOM   2185 C  CA  B GLN A 1 383 ? 17.17499 -28.55485 -19.17069 0.593 31.03203 ? 278 GLN A CA  1 
ATOM   2186 C  C   A GLN A 1 383 ? 18.15221 -27.79223 -20.07015 0.407 23.55978 ? 278 GLN A C   1 
ATOM   2187 C  C   B GLN A 1 383 ? 18.13569 -27.81878 -20.09318 0.593 23.46967 ? 278 GLN A C   1 
ATOM   2188 O  O   A GLN A 1 383 ? 17.75933 -26.81316 -20.71342 0.407 30.04100 ? 278 GLN A O   1 
ATOM   2189 O  O   B GLN A 1 383 ? 17.73668 -26.85869 -20.76126 0.593 30.17310 ? 278 GLN A O   1 
ATOM   2190 C  CB  A GLN A 1 383 ? 16.04042 -29.14630 -19.96916 0.407 38.81876 ? 278 GLN A CB  1 
ATOM   2191 C  CB  B GLN A 1 383 ? 15.95916 -29.10086 -19.92573 0.593 38.90640 ? 278 GLN A CB  1 
ATOM   2192 C  CG  A GLN A 1 383 ? 14.94965 -29.72404 -19.08979 0.407 38.93085 ? 278 GLN A CG  1 
ATOM   2193 C  CG  B GLN A 1 383 ? 15.28935 -30.29784 -19.23560 0.593 44.41340 ? 278 GLN A CG  1 
ATOM   2194 C  CD  A GLN A 1 383 ? 15.44870 -30.90905 -18.28044 0.407 40.36418 ? 278 GLN A CD  1 
ATOM   2195 C  CD  B GLN A 1 383 ? 13.75547 -30.27006 -19.30445 0.593 48.85476 ? 278 GLN A CD  1 
ATOM   2196 O  OE1 A GLN A 1 383 ? 16.30445 -31.67646 -18.74415 0.407 38.96780 ? 278 GLN A OE1 1 
ATOM   2197 O  OE1 B GLN A 1 383 ? 13.14864 -29.26844 -19.70701 0.593 35.69053 ? 278 GLN A OE1 1 
ATOM   2198 N  NE2 A GLN A 1 383 ? 14.93654 -31.05150 -17.05527 0.407 35.44980 ? 278 GLN A NE2 1 
ATOM   2199 N  NE2 B GLN A 1 383 ? 13.12677 -31.38174 -18.90549 0.593 41.72234 ? 278 GLN A NE2 1 
ATOM   2200 N  N   . ALA A 1 384 ? 19.40575 -28.22481 -20.09181 1.000 19.88233 ? 279 ALA A N   1 
ATOM   2201 C  CA  . ALA A 1 384 ? 20.42111 -27.57737 -20.93864 1.000 26.45025 ? 279 ALA A CA  1 
ATOM   2202 C  C   . ALA A 1 384 ? 20.05468 -27.74575 -22.42983 1.000 31.96157 ? 279 ALA A C   1 
ATOM   2203 O  O   . ALA A 1 384 ? 20.34725 -26.92981 -23.30729 1.000 34.99321 ? 279 ALA A O   1 
ATOM   2204 C  CB  . ALA A 1 384 ? 21.80150 -28.16077 -20.64141 1.000 33.26197 ? 279 ALA A CB  1 
ATOM   2205 O  OXT . ALA A 1 384 ? 19.36402 -28.68350 -22.79950 1.000 28.95428 ? 279 ALA A OXT 1 
HETATM 2206 N  N   . NO3 B 2 .   ? 17.83971 -1.30299  15.90535  1.000 30.92157 ? 301 NO3 A N   1 
HETATM 2207 O  O1  . NO3 B 2 .   ? 17.72581 -1.60519  14.68709  1.000 22.62228 ? 301 NO3 A O1  1 
HETATM 2208 O  O2  . NO3 B 2 .   ? 18.04746 -2.21774  16.75128  1.000 24.07729 ? 301 NO3 A O2  1 
HETATM 2209 O  O3  . NO3 B 2 .   ? 17.75682 -0.08268  16.27570  1.000 33.22837 ? 301 NO3 A O3  1 
HETATM 2210 CA CA  . CA  C 3 .   ? -0.89894 -20.53138 -0.01339  1.000 8.96821  ? 302 CA  A CA  1 
HETATM 2211 O  O   . HOH D 4 .   ? 23.09388 -30.82484 7.28640   1.000 29.20592 ? 401 HOH A O   1 
HETATM 2212 O  O   . HOH D 4 .   ? -1.80755 -22.31120 1.55369   1.000 12.26984 ? 402 HOH A O   1 
HETATM 2213 O  O   . HOH D 4 .   ? 26.38343 -4.17588  7.99153   1.000 24.86802 ? 403 HOH A O   1 
HETATM 2214 O  O   . HOH D 4 .   ? 31.34566 -10.13191 -8.67702  1.000 35.19071 ? 404 HOH A O   1 
HETATM 2215 O  O   . HOH D 4 .   ? 27.29659 -4.97374  -3.19188  1.000 27.40335 ? 405 HOH A O   1 
HETATM 2216 O  O   . HOH D 4 .   ? 22.09827 -30.46082 -9.08172  1.000 25.94969 ? 406 HOH A O   1 
HETATM 2217 O  O   . HOH D 4 .   ? 12.92380 -11.62019 5.22363   1.000 9.90072  ? 407 HOH A O   1 
HETATM 2218 O  O   . HOH D 4 .   ? -7.18829 -14.36422 1.88326   1.000 26.14300 ? 408 HOH A O   1 
HETATM 2219 O  O   . HOH D 4 .   ? 14.61597 -38.27462 -1.85470  1.000 19.69561 ? 409 HOH A O   1 
HETATM 2220 O  O   . HOH D 4 .   ? 0.35267  -4.66116  2.34042   1.000 18.26377 ? 410 HOH A O   1 
HETATM 2221 O  O   . HOH D 4 .   ? -3.40262 -28.53398 9.05956   1.000 22.26130 ? 411 HOH A O   1 
HETATM 2222 O  O   . HOH D 4 .   ? -2.33814 -25.68582 8.46707   1.000 25.65917 ? 412 HOH A O   1 
HETATM 2223 O  O   . HOH D 4 .   ? 8.23953  4.78082   -2.14009  1.000 30.29012 ? 413 HOH A O   1 
HETATM 2224 O  O   . HOH D 4 .   ? 13.63719 -13.57600 3.28188   1.000 11.23122 ? 414 HOH A O   1 
HETATM 2225 O  O   . HOH D 4 .   ? 25.26984 -21.93535 12.64734  1.000 29.44735 ? 415 HOH A O   1 
HETATM 2226 O  O   . HOH D 4 .   ? 20.63570 -17.57575 -11.24271 1.000 13.96274 ? 416 HOH A O   1 
HETATM 2227 O  O   . HOH D 4 .   ? 21.01492 -32.50633 -5.13478  1.000 14.12027 ? 417 HOH A O   1 
HETATM 2228 O  O   . HOH D 4 .   ? 5.78710  3.33131   6.17857   1.000 26.49404 ? 418 HOH A O   1 
HETATM 2229 O  O   . HOH D 4 .   ? 25.92161 -12.58328 -10.25481 1.000 27.44535 ? 419 HOH A O   1 
HETATM 2230 O  O   . HOH D 4 .   ? 14.26261 -19.33422 10.75795  1.000 23.35759 ? 420 HOH A O   1 
HETATM 2231 O  O   . HOH D 4 .   ? 14.92893 -23.53982 -15.59244 1.000 20.18296 ? 421 HOH A O   1 
HETATM 2232 O  O   . HOH D 4 .   ? -0.41019 -32.28698 8.21062   1.000 23.44621 ? 422 HOH A O   1 
HETATM 2233 O  O   . HOH D 4 .   ? 24.92487 -3.59017  -3.60456  1.000 17.82384 ? 423 HOH A O   1 
HETATM 2234 O  O   . HOH D 4 .   ? 5.39382  -16.53760 8.95925   1.000 16.14195 ? 424 HOH A O   1 
HETATM 2235 O  O   . HOH D 4 .   ? 3.72935  1.94186   5.17236   1.000 12.55021 ? 425 HOH A O   1 
HETATM 2236 O  O   . HOH D 4 .   ? 5.43062  5.12659   -1.92547  1.000 28.22461 ? 426 HOH A O   1 
HETATM 2237 O  O   . HOH D 4 .   ? 14.17685 -30.04646 -5.83596  1.000 16.15058 ? 427 HOH A O   1 
HETATM 2238 O  O   . HOH D 4 .   ? -3.62526 -5.03378  8.16467   1.000 14.62267 ? 428 HOH A O   1 
HETATM 2239 O  O   . HOH D 4 .   ? 15.90836 -31.31533 0.63762   1.000 11.16566 ? 429 HOH A O   1 
HETATM 2240 O  O   . HOH D 4 .   ? 13.07810 -39.32977 1.31369   1.000 28.77641 ? 430 HOH A O   1 
HETATM 2241 O  O   . HOH D 4 .   ? 4.97290  -8.36443  -10.24381 1.000 13.72232 ? 431 HOH A O   1 
HETATM 2242 O  O   . HOH D 4 .   ? 21.14747 -0.85872  12.68466  1.000 18.28374 ? 432 HOH A O   1 
HETATM 2243 O  O   . HOH D 4 .   ? 9.08774  -26.13909 -8.32921  1.000 10.29418 ? 433 HOH A O   1 
HETATM 2244 O  O   . HOH D 4 .   ? 14.86297 -38.83626 3.55396   1.000 29.04928 ? 434 HOH A O   1 
HETATM 2245 O  O   . HOH D 4 .   ? 12.56326 -35.03158 10.21255  1.000 29.13329 ? 435 HOH A O   1 
HETATM 2246 O  O   . HOH D 4 .   ? 30.58991 -5.36405  3.35805   1.000 19.16005 ? 436 HOH A O   1 
HETATM 2247 O  O   . HOH D 4 .   ? 22.03568 -37.84944 -6.84177  1.000 26.18675 ? 437 HOH A O   1 
HETATM 2248 O  O   . HOH D 4 .   ? -9.47264 -14.55247 12.48802  1.000 25.77540 ? 438 HOH A O   1 
HETATM 2249 O  O   . HOH D 4 .   ? -5.21816 -8.43676  14.46023  1.000 29.61414 ? 439 HOH A O   1 
HETATM 2250 O  O   . HOH D 4 .   ? 0.37007  -28.51271 2.97538   1.000 10.77513 ? 440 HOH A O   1 
HETATM 2251 O  O   . HOH D 4 .   ? 30.06489 -29.62577 -8.66345  1.000 24.53887 ? 441 HOH A O   1 
HETATM 2252 O  O   . HOH D 4 .   ? -3.25779 -16.02223 -4.02368  1.000 24.41953 ? 442 HOH A O   1 
HETATM 2253 O  O   . HOH D 4 .   ? 15.86382 -16.11990 -15.04472 1.000 11.13347 ? 443 HOH A O   1 
HETATM 2254 O  O   . HOH D 4 .   ? 0.20659  0.20659   0.00000   0.50  13.47954 ? 444 HOH A O   1 
HETATM 2255 O  O   . HOH D 4 .   ? -4.35693 -11.87980 -1.61029  1.000 16.16264 ? 445 HOH A O   1 
HETATM 2256 O  O   . HOH D 4 .   ? 18.60347 -32.41973 9.88249   1.000 27.50589 ? 446 HOH A O   1 
HETATM 2257 O  O   . HOH D 4 .   ? -5.665   -20.057   11.324    1.000 22.77019 ? 447 HOH A O   1 
HETATM 2258 O  O   . HOH D 4 .   ? 21.09961 -33.17400 -1.14262  1.000 20.28256 ? 448 HOH A O   1 
HETATM 2259 O  O   . HOH D 4 .   ? -0.37305 -19.84474 2.32292   1.000 10.33408 ? 449 HOH A O   1 
HETATM 2260 O  O   . HOH D 4 .   ? 9.85932  -24.54884 -14.85192 1.000 20.86939 ? 450 HOH A O   1 
HETATM 2261 O  O   . HOH D 4 .   ? -6.55202 -12.11253 5.16302   1.000 24.48554 ? 451 HOH A O   1 
HETATM 2262 O  O   . HOH D 4 .   ? 2.61516  -16.03150 -3.66074  1.000 13.80866 ? 452 HOH A O   1 
HETATM 2263 O  O   . HOH D 4 .   ? 16.90272 -21.64980 -10.61763 1.000 14.41168 ? 453 HOH A O   1 
HETATM 2264 O  O   . HOH D 4 .   ? 0.14201  -25.00723 16.03814  1.000 23.38967 ? 454 HOH A O   1 
HETATM 2265 O  O   . HOH D 4 .   ? 16.94680 -30.10763 10.40443  1.000 14.72477 ? 455 HOH A O   1 
HETATM 2266 O  O   . HOH D 4 .   ? 0.80832  -26.48106 -2.79860  1.000 15.24760 ? 456 HOH A O   1 
HETATM 2267 O  O   . HOH D 4 .   ? 0.22991  -17.48098 -3.49100  1.000 17.35276 ? 457 HOH A O   1 
HETATM 2268 O  O   . HOH D 4 .   ? 8.16228  -35.60855 -8.96418  1.000 25.89676 ? 458 HOH A O   1 
HETATM 2269 O  O   . HOH D 4 .   ? 8.96688  -33.98904 -2.65130  1.000 13.49779 ? 459 HOH A O   1 
HETATM 2270 O  O   . HOH D 4 .   ? 22.36580 -19.84375 0.02053   1.000 10.96644 ? 460 HOH A O   1 
HETATM 2271 O  O   . HOH D 4 .   ? 9.79915  -24.94166 -12.14807 1.000 14.22933 ? 461 HOH A O   1 
HETATM 2272 O  O   . HOH D 4 .   ? 27.35156 -19.72241 -19.06699 1.000 30.14045 ? 462 HOH A O   1 
HETATM 2273 O  O   . HOH D 4 .   ? 22.61321 -24.64210 0.88571   1.000 12.60914 ? 463 HOH A O   1 
HETATM 2274 O  O   . HOH D 4 .   ? 1.83818  -19.80280 -14.31061 1.000 26.72378 ? 464 HOH A O   1 
HETATM 2275 O  O   . HOH D 4 .   ? 0.651    -19.135   18.191    1.000 29.18144 ? 465 HOH A O   1 
HETATM 2276 O  O   . HOH D 4 .   ? 21.94500 -31.09686 -2.77332  1.000 16.06423 ? 466 HOH A O   1 
HETATM 2277 O  O   . HOH D 4 .   ? 2.05511  -16.54204 -6.41323  1.000 13.27326 ? 467 HOH A O   1 
HETATM 2278 O  O   . HOH D 4 .   ? 24.32554 -3.20924  6.82829   1.000 21.58438 ? 468 HOH A O   1 
HETATM 2279 O  O   . HOH D 4 .   ? -7.10326 -11.79879 7.94574   1.000 21.88179 ? 469 HOH A O   1 
HETATM 2280 O  O   . HOH D 4 .   ? 9.09228  -2.43748  15.88011  1.000 22.08179 ? 470 HOH A O   1 
HETATM 2281 O  O   . HOH D 4 .   ? 32.97173 -16.34616 9.03971   1.000 28.90298 ? 471 HOH A O   1 
HETATM 2282 O  O   . HOH D 4 .   ? 15.63717 -33.27279 9.68803   1.000 21.98318 ? 472 HOH A O   1 
HETATM 2283 O  O   . HOH D 4 .   ? 11.50531 2.75055   15.78183  1.000 21.66481 ? 473 HOH A O   1 
HETATM 2284 O  O   . HOH D 4 .   ? 0.88543  -0.07422  10.93646  1.000 28.26640 ? 474 HOH A O   1 
HETATM 2285 O  O   . HOH D 4 .   ? 3.98602  -10.56662 -12.43882 1.000 21.11112 ? 475 HOH A O   1 
HETATM 2286 O  O   . HOH D 4 .   ? -0.86792 -19.95133 -2.32796  1.000 14.73701 ? 476 HOH A O   1 
HETATM 2287 O  O   . HOH D 4 .   ? 24.88093 -24.88355 2.48960   1.000 13.87246 ? 477 HOH A O   1 
HETATM 2288 O  O   . HOH D 4 .   ? 21.82850 0.87894   0.36394   1.000 19.83357 ? 478 HOH A O   1 
HETATM 2289 O  O   . HOH D 4 .   ? 21.69905 -22.62465 -0.67070  1.000 10.71114 ? 479 HOH A O   1 
HETATM 2290 O  O   . HOH D 4 .   ? 18.99916 -17.72748 3.89158   1.000 9.68543  ? 480 HOH A O   1 
HETATM 2291 O  O   . HOH D 4 .   ? -6.75174 -7.92620  2.92925   1.000 29.95300 ? 481 HOH A O   1 
HETATM 2292 O  O   . HOH D 4 .   ? 32.10652 -15.33502 -0.94839  1.000 27.66274 ? 482 HOH A O   1 
HETATM 2293 O  O   . HOH D 4 .   ? 30.78665 -22.37747 -6.03049  1.000 25.21143 ? 483 HOH A O   1 
HETATM 2294 O  O   . HOH D 4 .   ? 12.92272 -13.76211 11.77715  1.000 24.25059 ? 484 HOH A O   1 
HETATM 2295 O  O   . HOH D 4 .   ? 1.79465  -33.74750 -1.97643  1.000 23.62005 ? 485 HOH A O   1 
HETATM 2296 O  O   . HOH D 4 .   ? 16.06288 -6.48937  4.99850   1.000 12.64729 ? 486 HOH A O   1 
HETATM 2297 O  O   . HOH D 4 .   ? 28.17954 -20.24820 -12.65923 1.000 27.36397 ? 487 HOH A O   1 
HETATM 2298 O  O   . HOH D 4 .   ? 2.07129  -3.85471  17.07422  1.000 27.52404 ? 488 HOH A O   1 
HETATM 2299 O  O   . HOH D 4 .   ? 19.02089 1.02594   13.84969  1.000 21.61082 ? 489 HOH A O   1 
HETATM 2300 O  O   . HOH D 4 .   ? 21.06273 -30.20099 5.71480   1.000 14.11933 ? 490 HOH A O   1 
HETATM 2301 O  O   . HOH D 4 .   ? 8.31702  -1.83461  -13.41410 1.000 26.15336 ? 491 HOH A O   1 
HETATM 2302 O  O   . HOH D 4 .   ? -6.220   -11.555   15.353    1.000 19.34981 ? 492 HOH A O   1 
HETATM 2303 O  O   . HOH D 4 .   ? 30.177   -14.999   9.819     1.000 13.84257 ? 493 HOH A O   1 
HETATM 2304 O  O   . HOH D 4 .   ? -1.72035 -25.02319 0.78873   1.000 28.58062 ? 494 HOH A O   1 
HETATM 2305 O  O   . HOH D 4 .   ? 3.76820  -7.25988  18.09924  1.000 32.49607 ? 495 HOH A O   1 
HETATM 2306 O  O   . HOH D 4 .   ? -2.86699 -21.62059 -1.13894  1.000 14.62870 ? 496 HOH A O   1 
HETATM 2307 O  O   . HOH D 4 .   ? 20.94722 -21.97438 12.96447  1.000 23.74492 ? 497 HOH A O   1 
HETATM 2308 O  O   . HOH D 4 .   ? 29.18011 -21.25885 9.62442   1.000 15.23601 ? 498 HOH A O   1 
HETATM 2309 O  O   . HOH D 4 .   ? 24.52136 -17.10970 13.97081  1.000 21.20749 ? 499 HOH A O   1 
HETATM 2310 O  O   . HOH D 4 .   ? 16.27089 6.50744   10.09776  1.000 32.06221 ? 500 HOH A O   1 
HETATM 2311 O  O   . HOH D 4 .   ? 0.24250  -27.56461 16.42436  1.000 29.23709 ? 501 HOH A O   1 
HETATM 2312 O  O   . HOH D 4 .   ? 0.53131  -11.13980 -11.73809 1.000 26.59194 ? 502 HOH A O   1 
HETATM 2313 O  O   . HOH D 4 .   ? 8.27378  -40.64959 5.72595   1.000 30.82861 ? 503 HOH A O   1 
HETATM 2314 O  O   . HOH D 4 .   ? 13.96232 5.14695   5.59285   1.000 19.54704 ? 504 HOH A O   1 
HETATM 2315 O  O   . HOH D 4 .   ? -0.06137 -18.70454 -6.81435  1.000 19.30384 ? 505 HOH A O   1 
HETATM 2316 O  O   . HOH D 4 .   ? 6.89631  -38.50254 4.30598   1.000 26.11252 ? 506 HOH A O   1 
HETATM 2317 O  O   . HOH D 4 .   ? 26.76458 -27.05835 1.36669   1.000 24.94029 ? 507 HOH A O   1 
HETATM 2318 O  O   . HOH D 4 .   ? -0.48663 -28.53601 -4.28586  1.000 28.51186 ? 508 HOH A O   1 
HETATM 2319 O  O   . HOH D 4 .   ? 10.58818 -13.54164 13.31611  1.000 26.06319 ? 509 HOH A O   1 
HETATM 2320 O  O   . HOH D 4 .   ? 32.079   -13.232   -11.446   1.000 29.88767 ? 510 HOH A O   1 
HETATM 2321 O  O   . HOH D 4 .   ? 13.77118 3.82574   15.95252  1.000 27.43141 ? 511 HOH A O   1 
# 
