data_8RPS
# 
_entry.id   8RPS 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8RPS         pdb_00008rps 10.2210/pdb8rps/pdb 
WWPDB D_1292135974 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-11-20 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8RPS 
_pdbx_database_status.recvd_initial_deposition_date   2024-01-17 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              rgds@st-andrews.ac.uk 
_pdbx_contact_author.name_first         Rafael 
_pdbx_contact_author.name_last          'da Silva' 
_pdbx_contact_author.name_mi            Guimaraes 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-1308-8190 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Devi, S.'       1 0000-0001-8651-2987 
'da Silva, R.G.' 2 0000-0002-1308-8190 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   GE 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Chembiochem 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1439-7633 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            25 
_citation.language                  ? 
_citation.page_first                e202400047 
_citation.page_last                 e202400047 
_citation.title                     
;Human 2'-Deoxynucleoside 5'-Phosphate N-Hydrolase 1: The Catalytic Roles of Tyr24 and Asp80.
;
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1002/cbic.202400047 
_citation.pdbx_database_id_PubMed   38350003 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Carberry, A.E.' 1 ? 
primary 'Devi, S.'       2 ? 
primary 'Harrison, D.J.' 3 ? 
primary 'da Silva, R.G.' 4 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 
;2'-deoxynucleoside 5'-phosphate N-hydrolase 1
;
16193.235 3   3.2.2.- D80N ? ? 
2 non-polymer syn "5-HYDROXYMETHYLURIDINE-2'-DEOXY-5'-MONOPHOSPHATE" 338.208   2   ?       ?    ? ? 
3 water       nat water                                              18.015    198 ?       ?    ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'c-Myc-responsive protein RCL' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GMRPALYFCGSIRGGREDRTLYERIVSRLRRFGTVLTEHVAAAELGARGEEAAGGDRLIHEQNLEWLQQADVVVAEVTQP
SLGVGYELGRAVAFNKRILCLFRPQSGRVLSAMIRGAADGSRFQVWDYEEGEVEALLDRYFEADP
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GMRPALYFCGSIRGGREDRTLYERIVSRLRRFGTVLTEHVAAAELGARGEEAAGGDRLIHEQNLEWLQQADVVVAEVTQP
SLGVGYELGRAVAFNKRILCLFRPQSGRVLSAMIRGAADGSRFQVWDYEEGEVEALLDRYFEADP
;
_entity_poly.pdbx_strand_id                 C,A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 "5-HYDROXYMETHYLURIDINE-2'-DEOXY-5'-MONOPHOSPHATE" 5HU 
3 water                                              HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   MET n 
1 3   ARG n 
1 4   PRO n 
1 5   ALA n 
1 6   LEU n 
1 7   TYR n 
1 8   PHE n 
1 9   CYS n 
1 10  GLY n 
1 11  SER n 
1 12  ILE n 
1 13  ARG n 
1 14  GLY n 
1 15  GLY n 
1 16  ARG n 
1 17  GLU n 
1 18  ASP n 
1 19  ARG n 
1 20  THR n 
1 21  LEU n 
1 22  TYR n 
1 23  GLU n 
1 24  ARG n 
1 25  ILE n 
1 26  VAL n 
1 27  SER n 
1 28  ARG n 
1 29  LEU n 
1 30  ARG n 
1 31  ARG n 
1 32  PHE n 
1 33  GLY n 
1 34  THR n 
1 35  VAL n 
1 36  LEU n 
1 37  THR n 
1 38  GLU n 
1 39  HIS n 
1 40  VAL n 
1 41  ALA n 
1 42  ALA n 
1 43  ALA n 
1 44  GLU n 
1 45  LEU n 
1 46  GLY n 
1 47  ALA n 
1 48  ARG n 
1 49  GLY n 
1 50  GLU n 
1 51  GLU n 
1 52  ALA n 
1 53  ALA n 
1 54  GLY n 
1 55  GLY n 
1 56  ASP n 
1 57  ARG n 
1 58  LEU n 
1 59  ILE n 
1 60  HIS n 
1 61  GLU n 
1 62  GLN n 
1 63  ASN n 
1 64  LEU n 
1 65  GLU n 
1 66  TRP n 
1 67  LEU n 
1 68  GLN n 
1 69  GLN n 
1 70  ALA n 
1 71  ASP n 
1 72  VAL n 
1 73  VAL n 
1 74  VAL n 
1 75  ALA n 
1 76  GLU n 
1 77  VAL n 
1 78  THR n 
1 79  GLN n 
1 80  PRO n 
1 81  SER n 
1 82  LEU n 
1 83  GLY n 
1 84  VAL n 
1 85  GLY n 
1 86  TYR n 
1 87  GLU n 
1 88  LEU n 
1 89  GLY n 
1 90  ARG n 
1 91  ALA n 
1 92  VAL n 
1 93  ALA n 
1 94  PHE n 
1 95  ASN n 
1 96  LYS n 
1 97  ARG n 
1 98  ILE n 
1 99  LEU n 
1 100 CYS n 
1 101 LEU n 
1 102 PHE n 
1 103 ARG n 
1 104 PRO n 
1 105 GLN n 
1 106 SER n 
1 107 GLY n 
1 108 ARG n 
1 109 VAL n 
1 110 LEU n 
1 111 SER n 
1 112 ALA n 
1 113 MET n 
1 114 ILE n 
1 115 ARG n 
1 116 GLY n 
1 117 ALA n 
1 118 ALA n 
1 119 ASP n 
1 120 GLY n 
1 121 SER n 
1 122 ARG n 
1 123 PHE n 
1 124 GLN n 
1 125 VAL n 
1 126 TRP n 
1 127 ASP n 
1 128 TYR n 
1 129 GLU n 
1 130 GLU n 
1 131 GLY n 
1 132 GLU n 
1 133 VAL n 
1 134 GLU n 
1 135 ALA n 
1 136 LEU n 
1 137 LEU n 
1 138 ASP n 
1 139 ARG n 
1 140 TYR n 
1 141 PHE n 
1 142 GLU n 
1 143 ALA n 
1 144 ASP n 
1 145 PRO n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   145 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'DNPH1, C6orf108, RCL' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
5HU 'DNA linking'       n "5-HYDROXYMETHYLURIDINE-2'-DEOXY-5'-MONOPHOSPHATE" ? 'C10 H15 N2 O9 P' 338.208 
ALA 'L-peptide linking' y ALANINE                                            ? 'C3 H7 N O2'      89.093  
ARG 'L-peptide linking' y ARGININE                                           ? 'C6 H15 N4 O2 1'  175.209 
ASN 'L-peptide linking' y ASPARAGINE                                         ? 'C4 H8 N2 O3'     132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                    ? 'C4 H7 N O4'      133.103 
CYS 'L-peptide linking' y CYSTEINE                                           ? 'C3 H7 N O2 S'    121.158 
GLN 'L-peptide linking' y GLUTAMINE                                          ? 'C5 H10 N2 O3'    146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                    ? 'C5 H9 N O4'      147.129 
GLY 'peptide linking'   y GLYCINE                                            ? 'C2 H5 N O2'      75.067  
HIS 'L-peptide linking' y HISTIDINE                                          ? 'C6 H10 N3 O2 1'  156.162 
HOH non-polymer         . WATER                                              ? 'H2 O'            18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                         ? 'C6 H13 N O2'     131.173 
LEU 'L-peptide linking' y LEUCINE                                            ? 'C6 H13 N O2'     131.173 
LYS 'L-peptide linking' y LYSINE                                             ? 'C6 H15 N2 O2 1'  147.195 
MET 'L-peptide linking' y METHIONINE                                         ? 'C5 H11 N O2 S'   149.211 
PHE 'L-peptide linking' y PHENYLALANINE                                      ? 'C9 H11 N O2'     165.189 
PRO 'L-peptide linking' y PROLINE                                            ? 'C5 H9 N O2'      115.130 
SER 'L-peptide linking' y SERINE                                             ? 'C3 H7 N O3'      105.093 
THR 'L-peptide linking' y THREONINE                                          ? 'C4 H9 N O3'      119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                         ? 'C11 H12 N2 O2'   204.225 
TYR 'L-peptide linking' y TYROSINE                                           ? 'C9 H11 N O3'     181.189 
VAL 'L-peptide linking' y VALINE                                             ? 'C5 H11 N O2'     117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   18  ?   ?   ?   C . n 
A 1 2   MET 2   19  19  MET MET C . n 
A 1 3   ARG 3   20  20  ARG ARG C . n 
A 1 4   PRO 4   21  21  PRO PRO C . n 
A 1 5   ALA 5   22  22  ALA ALA C . n 
A 1 6   LEU 6   23  23  LEU LEU C . n 
A 1 7   TYR 7   24  24  TYR TYR C . n 
A 1 8   PHE 8   25  25  PHE PHE C . n 
A 1 9   CYS 9   26  26  CYS CYS C . n 
A 1 10  GLY 10  27  27  GLY GLY C . n 
A 1 11  SER 11  28  28  SER SER C . n 
A 1 12  ILE 12  29  29  ILE ILE C . n 
A 1 13  ARG 13  30  30  ARG ARG C . n 
A 1 14  GLY 14  31  31  GLY GLY C . n 
A 1 15  GLY 15  32  32  GLY GLY C . n 
A 1 16  ARG 16  33  33  ARG ARG C . n 
A 1 17  GLU 17  34  34  GLU GLU C . n 
A 1 18  ASP 18  35  35  ASP ASP C . n 
A 1 19  ARG 19  36  36  ARG ARG C . n 
A 1 20  THR 20  37  37  THR THR C . n 
A 1 21  LEU 21  38  38  LEU LEU C . n 
A 1 22  TYR 22  39  39  TYR TYR C . n 
A 1 23  GLU 23  40  40  GLU GLU C . n 
A 1 24  ARG 24  41  41  ARG ARG C . n 
A 1 25  ILE 25  42  42  ILE ILE C . n 
A 1 26  VAL 26  43  43  VAL VAL C . n 
A 1 27  SER 27  44  44  SER SER C . n 
A 1 28  ARG 28  45  45  ARG ARG C . n 
A 1 29  LEU 29  46  46  LEU LEU C . n 
A 1 30  ARG 30  47  47  ARG ARG C . n 
A 1 31  ARG 31  48  48  ARG ARG C . n 
A 1 32  PHE 32  49  49  PHE PHE C . n 
A 1 33  GLY 33  50  50  GLY GLY C . n 
A 1 34  THR 34  51  51  THR THR C . n 
A 1 35  VAL 35  52  52  VAL VAL C . n 
A 1 36  LEU 36  53  53  LEU LEU C . n 
A 1 37  THR 37  54  54  THR THR C . n 
A 1 38  GLU 38  55  55  GLU GLU C . n 
A 1 39  HIS 39  56  56  HIS HIS C . n 
A 1 40  VAL 40  57  57  VAL VAL C . n 
A 1 41  ALA 41  58  58  ALA ALA C . n 
A 1 42  ALA 42  59  ?   ?   ?   C . n 
A 1 43  ALA 43  60  ?   ?   ?   C . n 
A 1 44  GLU 44  61  ?   ?   ?   C . n 
A 1 45  LEU 45  62  ?   ?   ?   C . n 
A 1 46  GLY 46  63  ?   ?   ?   C . n 
A 1 47  ALA 47  64  ?   ?   ?   C . n 
A 1 48  ARG 48  65  ?   ?   ?   C . n 
A 1 49  GLY 49  66  ?   ?   ?   C . n 
A 1 50  GLU 50  67  ?   ?   ?   C . n 
A 1 51  GLU 51  68  ?   ?   ?   C . n 
A 1 52  ALA 52  69  ?   ?   ?   C . n 
A 1 53  ALA 53  70  ?   ?   ?   C . n 
A 1 54  GLY 54  71  71  GLY GLY C . n 
A 1 55  GLY 55  72  72  GLY GLY C . n 
A 1 56  ASP 56  73  73  ASP ASP C . n 
A 1 57  ARG 57  74  74  ARG ARG C . n 
A 1 58  LEU 58  75  75  LEU LEU C . n 
A 1 59  ILE 59  76  76  ILE ILE C . n 
A 1 60  HIS 60  77  77  HIS HIS C . n 
A 1 61  GLU 61  78  78  GLU GLU C . n 
A 1 62  GLN 62  79  79  GLN GLN C . n 
A 1 63  ASN 63  80  80  ASN ASN C . n 
A 1 64  LEU 64  81  81  LEU LEU C . n 
A 1 65  GLU 65  82  82  GLU GLU C . n 
A 1 66  TRP 66  83  83  TRP TRP C . n 
A 1 67  LEU 67  84  84  LEU LEU C . n 
A 1 68  GLN 68  85  85  GLN GLN C . n 
A 1 69  GLN 69  86  86  GLN GLN C . n 
A 1 70  ALA 70  87  87  ALA ALA C . n 
A 1 71  ASP 71  88  88  ASP ASP C . n 
A 1 72  VAL 72  89  89  VAL VAL C . n 
A 1 73  VAL 73  90  90  VAL VAL C . n 
A 1 74  VAL 74  91  91  VAL VAL C . n 
A 1 75  ALA 75  92  92  ALA ALA C . n 
A 1 76  GLU 76  93  93  GLU GLU C . n 
A 1 77  VAL 77  94  94  VAL VAL C . n 
A 1 78  THR 78  95  95  THR THR C . n 
A 1 79  GLN 79  96  96  GLN GLN C . n 
A 1 80  PRO 80  97  97  PRO PRO C . n 
A 1 81  SER 81  98  98  SER SER C . n 
A 1 82  LEU 82  99  99  LEU LEU C . n 
A 1 83  GLY 83  100 100 GLY GLY C . n 
A 1 84  VAL 84  101 101 VAL VAL C . n 
A 1 85  GLY 85  102 102 GLY GLY C . n 
A 1 86  TYR 86  103 103 TYR TYR C . n 
A 1 87  GLU 87  104 104 GLU GLU C . n 
A 1 88  LEU 88  105 105 LEU LEU C . n 
A 1 89  GLY 89  106 106 GLY GLY C . n 
A 1 90  ARG 90  107 107 ARG ARG C . n 
A 1 91  ALA 91  108 108 ALA ALA C . n 
A 1 92  VAL 92  109 109 VAL VAL C . n 
A 1 93  ALA 93  110 110 ALA ALA C . n 
A 1 94  PHE 94  111 111 PHE PHE C . n 
A 1 95  ASN 95  112 112 ASN ASN C . n 
A 1 96  LYS 96  113 113 LYS LYS C . n 
A 1 97  ARG 97  114 114 ARG ARG C . n 
A 1 98  ILE 98  115 115 ILE ILE C . n 
A 1 99  LEU 99  116 116 LEU LEU C . n 
A 1 100 CYS 100 117 117 CYS CYS C . n 
A 1 101 LEU 101 118 118 LEU LEU C . n 
A 1 102 PHE 102 119 119 PHE PHE C . n 
A 1 103 ARG 103 120 120 ARG ARG C . n 
A 1 104 PRO 104 121 121 PRO PRO C . n 
A 1 105 GLN 105 122 122 GLN GLN C . n 
A 1 106 SER 106 123 123 SER SER C . n 
A 1 107 GLY 107 124 124 GLY GLY C . n 
A 1 108 ARG 108 125 125 ARG ARG C . n 
A 1 109 VAL 109 126 126 VAL VAL C . n 
A 1 110 LEU 110 127 127 LEU LEU C . n 
A 1 111 SER 111 128 128 SER SER C . n 
A 1 112 ALA 112 129 129 ALA ALA C . n 
A 1 113 MET 113 130 130 MET MET C . n 
A 1 114 ILE 114 131 131 ILE ILE C . n 
A 1 115 ARG 115 132 132 ARG ARG C . n 
A 1 116 GLY 116 133 133 GLY GLY C . n 
A 1 117 ALA 117 134 134 ALA ALA C . n 
A 1 118 ALA 118 135 135 ALA ALA C . n 
A 1 119 ASP 119 136 136 ASP ASP C . n 
A 1 120 GLY 120 137 137 GLY GLY C . n 
A 1 121 SER 121 138 138 SER SER C . n 
A 1 122 ARG 122 139 139 ARG ARG C . n 
A 1 123 PHE 123 140 140 PHE PHE C . n 
A 1 124 GLN 124 141 141 GLN GLN C . n 
A 1 125 VAL 125 142 142 VAL VAL C . n 
A 1 126 TRP 126 143 143 TRP TRP C . n 
A 1 127 ASP 127 144 144 ASP ASP C . n 
A 1 128 TYR 128 145 145 TYR TYR C . n 
A 1 129 GLU 129 146 146 GLU GLU C . n 
A 1 130 GLU 130 147 147 GLU GLU C . n 
A 1 131 GLY 131 148 148 GLY GLY C . n 
A 1 132 GLU 132 149 149 GLU GLU C . n 
A 1 133 VAL 133 150 150 VAL VAL C . n 
A 1 134 GLU 134 151 151 GLU GLU C . n 
A 1 135 ALA 135 152 152 ALA ALA C . n 
A 1 136 LEU 136 153 153 LEU LEU C . n 
A 1 137 LEU 137 154 154 LEU LEU C . n 
A 1 138 ASP 138 155 155 ASP ASP C . n 
A 1 139 ARG 139 156 156 ARG ARG C . n 
A 1 140 TYR 140 157 157 TYR TYR C . n 
A 1 141 PHE 141 158 158 PHE PHE C . n 
A 1 142 GLU 142 159 159 GLU GLU C . n 
A 1 143 ALA 143 160 ?   ?   ?   C . n 
A 1 144 ASP 144 161 ?   ?   ?   C . n 
A 1 145 PRO 145 162 ?   ?   ?   C . n 
B 1 1   GLY 1   18  18  GLY GLY A . n 
B 1 2   MET 2   19  19  MET MET A . n 
B 1 3   ARG 3   20  20  ARG ARG A . n 
B 1 4   PRO 4   21  21  PRO PRO A . n 
B 1 5   ALA 5   22  22  ALA ALA A . n 
B 1 6   LEU 6   23  23  LEU LEU A . n 
B 1 7   TYR 7   24  24  TYR TYR A . n 
B 1 8   PHE 8   25  25  PHE PHE A . n 
B 1 9   CYS 9   26  26  CYS CYS A . n 
B 1 10  GLY 10  27  27  GLY GLY A . n 
B 1 11  SER 11  28  28  SER SER A . n 
B 1 12  ILE 12  29  29  ILE ILE A . n 
B 1 13  ARG 13  30  30  ARG ARG A . n 
B 1 14  GLY 14  31  31  GLY GLY A . n 
B 1 15  GLY 15  32  32  GLY GLY A . n 
B 1 16  ARG 16  33  33  ARG ARG A . n 
B 1 17  GLU 17  34  34  GLU GLU A . n 
B 1 18  ASP 18  35  35  ASP ASP A . n 
B 1 19  ARG 19  36  36  ARG ARG A . n 
B 1 20  THR 20  37  37  THR THR A . n 
B 1 21  LEU 21  38  38  LEU LEU A . n 
B 1 22  TYR 22  39  39  TYR TYR A . n 
B 1 23  GLU 23  40  40  GLU GLU A . n 
B 1 24  ARG 24  41  41  ARG ARG A . n 
B 1 25  ILE 25  42  42  ILE ILE A . n 
B 1 26  VAL 26  43  43  VAL VAL A . n 
B 1 27  SER 27  44  44  SER SER A . n 
B 1 28  ARG 28  45  45  ARG ARG A . n 
B 1 29  LEU 29  46  46  LEU LEU A . n 
B 1 30  ARG 30  47  47  ARG ARG A . n 
B 1 31  ARG 31  48  48  ARG ARG A . n 
B 1 32  PHE 32  49  49  PHE PHE A . n 
B 1 33  GLY 33  50  50  GLY GLY A . n 
B 1 34  THR 34  51  51  THR THR A . n 
B 1 35  VAL 35  52  52  VAL VAL A . n 
B 1 36  LEU 36  53  53  LEU LEU A . n 
B 1 37  THR 37  54  54  THR THR A . n 
B 1 38  GLU 38  55  55  GLU GLU A . n 
B 1 39  HIS 39  56  56  HIS HIS A . n 
B 1 40  VAL 40  57  ?   ?   ?   A . n 
B 1 41  ALA 41  58  ?   ?   ?   A . n 
B 1 42  ALA 42  59  ?   ?   ?   A . n 
B 1 43  ALA 43  60  ?   ?   ?   A . n 
B 1 44  GLU 44  61  ?   ?   ?   A . n 
B 1 45  LEU 45  62  ?   ?   ?   A . n 
B 1 46  GLY 46  63  ?   ?   ?   A . n 
B 1 47  ALA 47  64  ?   ?   ?   A . n 
B 1 48  ARG 48  65  ?   ?   ?   A . n 
B 1 49  GLY 49  66  ?   ?   ?   A . n 
B 1 50  GLU 50  67  ?   ?   ?   A . n 
B 1 51  GLU 51  68  ?   ?   ?   A . n 
B 1 52  ALA 52  69  ?   ?   ?   A . n 
B 1 53  ALA 53  70  70  ALA ALA A . n 
B 1 54  GLY 54  71  71  GLY GLY A . n 
B 1 55  GLY 55  72  72  GLY GLY A . n 
B 1 56  ASP 56  73  73  ASP ASP A . n 
B 1 57  ARG 57  74  74  ARG ARG A . n 
B 1 58  LEU 58  75  75  LEU LEU A . n 
B 1 59  ILE 59  76  76  ILE ILE A . n 
B 1 60  HIS 60  77  77  HIS HIS A . n 
B 1 61  GLU 61  78  78  GLU GLU A . n 
B 1 62  GLN 62  79  79  GLN GLN A . n 
B 1 63  ASN 63  80  80  ASN ASN A . n 
B 1 64  LEU 64  81  81  LEU LEU A . n 
B 1 65  GLU 65  82  82  GLU GLU A . n 
B 1 66  TRP 66  83  83  TRP TRP A . n 
B 1 67  LEU 67  84  84  LEU LEU A . n 
B 1 68  GLN 68  85  85  GLN GLN A . n 
B 1 69  GLN 69  86  86  GLN GLN A . n 
B 1 70  ALA 70  87  87  ALA ALA A . n 
B 1 71  ASP 71  88  88  ASP ASP A . n 
B 1 72  VAL 72  89  89  VAL VAL A . n 
B 1 73  VAL 73  90  90  VAL VAL A . n 
B 1 74  VAL 74  91  91  VAL VAL A . n 
B 1 75  ALA 75  92  92  ALA ALA A . n 
B 1 76  GLU 76  93  93  GLU GLU A . n 
B 1 77  VAL 77  94  94  VAL VAL A . n 
B 1 78  THR 78  95  95  THR THR A . n 
B 1 79  GLN 79  96  96  GLN GLN A . n 
B 1 80  PRO 80  97  97  PRO PRO A . n 
B 1 81  SER 81  98  98  SER SER A . n 
B 1 82  LEU 82  99  99  LEU LEU A . n 
B 1 83  GLY 83  100 100 GLY GLY A . n 
B 1 84  VAL 84  101 101 VAL VAL A . n 
B 1 85  GLY 85  102 102 GLY GLY A . n 
B 1 86  TYR 86  103 103 TYR TYR A . n 
B 1 87  GLU 87  104 104 GLU GLU A . n 
B 1 88  LEU 88  105 105 LEU LEU A . n 
B 1 89  GLY 89  106 106 GLY GLY A . n 
B 1 90  ARG 90  107 107 ARG ARG A . n 
B 1 91  ALA 91  108 108 ALA ALA A . n 
B 1 92  VAL 92  109 109 VAL VAL A . n 
B 1 93  ALA 93  110 110 ALA ALA A . n 
B 1 94  PHE 94  111 111 PHE PHE A . n 
B 1 95  ASN 95  112 112 ASN ASN A . n 
B 1 96  LYS 96  113 113 LYS LYS A . n 
B 1 97  ARG 97  114 114 ARG ARG A . n 
B 1 98  ILE 98  115 115 ILE ILE A . n 
B 1 99  LEU 99  116 116 LEU LEU A . n 
B 1 100 CYS 100 117 117 CYS CYS A . n 
B 1 101 LEU 101 118 118 LEU LEU A . n 
B 1 102 PHE 102 119 119 PHE PHE A . n 
B 1 103 ARG 103 120 120 ARG ARG A . n 
B 1 104 PRO 104 121 121 PRO PRO A . n 
B 1 105 GLN 105 122 122 GLN GLN A . n 
B 1 106 SER 106 123 123 SER SER A . n 
B 1 107 GLY 107 124 124 GLY GLY A . n 
B 1 108 ARG 108 125 125 ARG ARG A . n 
B 1 109 VAL 109 126 126 VAL VAL A . n 
B 1 110 LEU 110 127 127 LEU LEU A . n 
B 1 111 SER 111 128 128 SER SER A . n 
B 1 112 ALA 112 129 129 ALA ALA A . n 
B 1 113 MET 113 130 130 MET MET A . n 
B 1 114 ILE 114 131 131 ILE ILE A . n 
B 1 115 ARG 115 132 132 ARG ARG A . n 
B 1 116 GLY 116 133 133 GLY GLY A . n 
B 1 117 ALA 117 134 134 ALA ALA A . n 
B 1 118 ALA 118 135 135 ALA ALA A . n 
B 1 119 ASP 119 136 136 ASP ASP A . n 
B 1 120 GLY 120 137 137 GLY GLY A . n 
B 1 121 SER 121 138 138 SER SER A . n 
B 1 122 ARG 122 139 139 ARG ARG A . n 
B 1 123 PHE 123 140 140 PHE PHE A . n 
B 1 124 GLN 124 141 141 GLN GLN A . n 
B 1 125 VAL 125 142 142 VAL VAL A . n 
B 1 126 TRP 126 143 143 TRP TRP A . n 
B 1 127 ASP 127 144 144 ASP ASP A . n 
B 1 128 TYR 128 145 145 TYR TYR A . n 
B 1 129 GLU 129 146 146 GLU GLU A . n 
B 1 130 GLU 130 147 147 GLU GLU A . n 
B 1 131 GLY 131 148 148 GLY GLY A . n 
B 1 132 GLU 132 149 149 GLU GLU A . n 
B 1 133 VAL 133 150 150 VAL VAL A . n 
B 1 134 GLU 134 151 151 GLU GLU A . n 
B 1 135 ALA 135 152 152 ALA ALA A . n 
B 1 136 LEU 136 153 153 LEU LEU A . n 
B 1 137 LEU 137 154 154 LEU LEU A . n 
B 1 138 ASP 138 155 155 ASP ASP A . n 
B 1 139 ARG 139 156 156 ARG ARG A . n 
B 1 140 TYR 140 157 157 TYR TYR A . n 
B 1 141 PHE 141 158 158 PHE PHE A . n 
B 1 142 GLU 142 159 159 GLU GLU A . n 
B 1 143 ALA 143 160 ?   ?   ?   A . n 
B 1 144 ASP 144 161 ?   ?   ?   A . n 
B 1 145 PRO 145 162 ?   ?   ?   A . n 
C 1 1   GLY 1   18  18  GLY GLY B . n 
C 1 2   MET 2   19  19  MET MET B . n 
C 1 3   ARG 3   20  20  ARG ARG B . n 
C 1 4   PRO 4   21  21  PRO PRO B . n 
C 1 5   ALA 5   22  22  ALA ALA B . n 
C 1 6   LEU 6   23  23  LEU LEU B . n 
C 1 7   TYR 7   24  24  TYR TYR B . n 
C 1 8   PHE 8   25  25  PHE PHE B . n 
C 1 9   CYS 9   26  26  CYS CYS B . n 
C 1 10  GLY 10  27  27  GLY GLY B . n 
C 1 11  SER 11  28  28  SER SER B . n 
C 1 12  ILE 12  29  29  ILE ILE B . n 
C 1 13  ARG 13  30  30  ARG ARG B . n 
C 1 14  GLY 14  31  31  GLY GLY B . n 
C 1 15  GLY 15  32  32  GLY GLY B . n 
C 1 16  ARG 16  33  33  ARG ARG B . n 
C 1 17  GLU 17  34  34  GLU GLU B . n 
C 1 18  ASP 18  35  35  ASP ASP B . n 
C 1 19  ARG 19  36  36  ARG ARG B . n 
C 1 20  THR 20  37  37  THR THR B . n 
C 1 21  LEU 21  38  38  LEU LEU B . n 
C 1 22  TYR 22  39  39  TYR TYR B . n 
C 1 23  GLU 23  40  40  GLU GLU B . n 
C 1 24  ARG 24  41  41  ARG ARG B . n 
C 1 25  ILE 25  42  42  ILE ILE B . n 
C 1 26  VAL 26  43  43  VAL VAL B . n 
C 1 27  SER 27  44  44  SER SER B . n 
C 1 28  ARG 28  45  45  ARG ARG B . n 
C 1 29  LEU 29  46  46  LEU LEU B . n 
C 1 30  ARG 30  47  47  ARG ARG B . n 
C 1 31  ARG 31  48  48  ARG ARG B . n 
C 1 32  PHE 32  49  49  PHE PHE B . n 
C 1 33  GLY 33  50  50  GLY GLY B . n 
C 1 34  THR 34  51  51  THR THR B . n 
C 1 35  VAL 35  52  52  VAL VAL B . n 
C 1 36  LEU 36  53  53  LEU LEU B . n 
C 1 37  THR 37  54  54  THR THR B . n 
C 1 38  GLU 38  55  55  GLU GLU B . n 
C 1 39  HIS 39  56  56  HIS HIS B . n 
C 1 40  VAL 40  57  57  VAL VAL B . n 
C 1 41  ALA 41  58  ?   ?   ?   B . n 
C 1 42  ALA 42  59  ?   ?   ?   B . n 
C 1 43  ALA 43  60  ?   ?   ?   B . n 
C 1 44  GLU 44  61  ?   ?   ?   B . n 
C 1 45  LEU 45  62  ?   ?   ?   B . n 
C 1 46  GLY 46  63  ?   ?   ?   B . n 
C 1 47  ALA 47  64  ?   ?   ?   B . n 
C 1 48  ARG 48  65  ?   ?   ?   B . n 
C 1 49  GLY 49  66  ?   ?   ?   B . n 
C 1 50  GLU 50  67  ?   ?   ?   B . n 
C 1 51  GLU 51  68  ?   ?   ?   B . n 
C 1 52  ALA 52  69  ?   ?   ?   B . n 
C 1 53  ALA 53  70  ?   ?   ?   B . n 
C 1 54  GLY 54  71  ?   ?   ?   B . n 
C 1 55  GLY 55  72  72  GLY GLY B . n 
C 1 56  ASP 56  73  73  ASP ASP B . n 
C 1 57  ARG 57  74  74  ARG ARG B . n 
C 1 58  LEU 58  75  75  LEU LEU B . n 
C 1 59  ILE 59  76  76  ILE ILE B . n 
C 1 60  HIS 60  77  77  HIS HIS B . n 
C 1 61  GLU 61  78  78  GLU GLU B . n 
C 1 62  GLN 62  79  79  GLN GLN B . n 
C 1 63  ASN 63  80  80  ASN ASN B . n 
C 1 64  LEU 64  81  81  LEU LEU B . n 
C 1 65  GLU 65  82  82  GLU GLU B . n 
C 1 66  TRP 66  83  83  TRP TRP B . n 
C 1 67  LEU 67  84  84  LEU LEU B . n 
C 1 68  GLN 68  85  85  GLN GLN B . n 
C 1 69  GLN 69  86  86  GLN GLN B . n 
C 1 70  ALA 70  87  87  ALA ALA B . n 
C 1 71  ASP 71  88  88  ASP ASP B . n 
C 1 72  VAL 72  89  89  VAL VAL B . n 
C 1 73  VAL 73  90  90  VAL VAL B . n 
C 1 74  VAL 74  91  91  VAL VAL B . n 
C 1 75  ALA 75  92  92  ALA ALA B . n 
C 1 76  GLU 76  93  93  GLU GLU B . n 
C 1 77  VAL 77  94  94  VAL VAL B . n 
C 1 78  THR 78  95  95  THR THR B . n 
C 1 79  GLN 79  96  96  GLN GLN B . n 
C 1 80  PRO 80  97  97  PRO PRO B . n 
C 1 81  SER 81  98  98  SER SER B . n 
C 1 82  LEU 82  99  99  LEU LEU B . n 
C 1 83  GLY 83  100 100 GLY GLY B . n 
C 1 84  VAL 84  101 101 VAL VAL B . n 
C 1 85  GLY 85  102 102 GLY GLY B . n 
C 1 86  TYR 86  103 103 TYR TYR B . n 
C 1 87  GLU 87  104 104 GLU GLU B . n 
C 1 88  LEU 88  105 105 LEU LEU B . n 
C 1 89  GLY 89  106 106 GLY GLY B . n 
C 1 90  ARG 90  107 107 ARG ARG B . n 
C 1 91  ALA 91  108 108 ALA ALA B . n 
C 1 92  VAL 92  109 109 VAL VAL B . n 
C 1 93  ALA 93  110 110 ALA ALA B . n 
C 1 94  PHE 94  111 111 PHE PHE B . n 
C 1 95  ASN 95  112 112 ASN ASN B . n 
C 1 96  LYS 96  113 113 LYS LYS B . n 
C 1 97  ARG 97  114 114 ARG ARG B . n 
C 1 98  ILE 98  115 115 ILE ILE B . n 
C 1 99  LEU 99  116 116 LEU LEU B . n 
C 1 100 CYS 100 117 117 CYS CYS B . n 
C 1 101 LEU 101 118 118 LEU LEU B . n 
C 1 102 PHE 102 119 119 PHE PHE B . n 
C 1 103 ARG 103 120 120 ARG ARG B . n 
C 1 104 PRO 104 121 121 PRO PRO B . n 
C 1 105 GLN 105 122 122 GLN GLN B . n 
C 1 106 SER 106 123 123 SER SER B . n 
C 1 107 GLY 107 124 124 GLY GLY B . n 
C 1 108 ARG 108 125 125 ARG ARG B . n 
C 1 109 VAL 109 126 126 VAL VAL B . n 
C 1 110 LEU 110 127 127 LEU LEU B . n 
C 1 111 SER 111 128 128 SER SER B . n 
C 1 112 ALA 112 129 129 ALA ALA B . n 
C 1 113 MET 113 130 130 MET MET B . n 
C 1 114 ILE 114 131 131 ILE ILE B . n 
C 1 115 ARG 115 132 132 ARG ARG B . n 
C 1 116 GLY 116 133 133 GLY GLY B . n 
C 1 117 ALA 117 134 134 ALA ALA B . n 
C 1 118 ALA 118 135 135 ALA ALA B . n 
C 1 119 ASP 119 136 136 ASP ASP B . n 
C 1 120 GLY 120 137 137 GLY GLY B . n 
C 1 121 SER 121 138 138 SER SER B . n 
C 1 122 ARG 122 139 139 ARG ARG B . n 
C 1 123 PHE 123 140 140 PHE PHE B . n 
C 1 124 GLN 124 141 141 GLN GLN B . n 
C 1 125 VAL 125 142 142 VAL VAL B . n 
C 1 126 TRP 126 143 143 TRP TRP B . n 
C 1 127 ASP 127 144 144 ASP ASP B . n 
C 1 128 TYR 128 145 145 TYR TYR B . n 
C 1 129 GLU 129 146 146 GLU GLU B . n 
C 1 130 GLU 130 147 147 GLU GLU B . n 
C 1 131 GLY 131 148 148 GLY GLY B . n 
C 1 132 GLU 132 149 149 GLU GLU B . n 
C 1 133 VAL 133 150 150 VAL VAL B . n 
C 1 134 GLU 134 151 151 GLU GLU B . n 
C 1 135 ALA 135 152 152 ALA ALA B . n 
C 1 136 LEU 136 153 153 LEU LEU B . n 
C 1 137 LEU 137 154 154 LEU LEU B . n 
C 1 138 ASP 138 155 155 ASP ASP B . n 
C 1 139 ARG 139 156 156 ARG ARG B . n 
C 1 140 TYR 140 157 157 TYR TYR B . n 
C 1 141 PHE 141 158 158 PHE PHE B . n 
C 1 142 GLU 142 159 159 GLU GLU B . n 
C 1 143 ALA 143 160 160 ALA ALA B . n 
C 1 144 ASP 144 161 161 ASP ASP B . n 
C 1 145 PRO 145 162 162 PRO PRO B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        5HU 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   5HU 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
D 2 5HU 1  201 1   5HU 5HU C . 
E 2 5HU 1  201 2   5HU 5HU A . 
F 3 HOH 1  301 28  HOH HOH C . 
F 3 HOH 2  302 180 HOH HOH C . 
F 3 HOH 3  303 15  HOH HOH C . 
F 3 HOH 4  304 133 HOH HOH C . 
F 3 HOH 5  305 146 HOH HOH C . 
F 3 HOH 6  306 186 HOH HOH C . 
F 3 HOH 7  307 115 HOH HOH C . 
F 3 HOH 8  308 18  HOH HOH C . 
F 3 HOH 9  309 38  HOH HOH C . 
F 3 HOH 10 310 189 HOH HOH C . 
F 3 HOH 11 311 134 HOH HOH C . 
F 3 HOH 12 312 198 HOH HOH C . 
F 3 HOH 13 313 170 HOH HOH C . 
F 3 HOH 14 314 46  HOH HOH C . 
F 3 HOH 15 315 31  HOH HOH C . 
F 3 HOH 16 316 185 HOH HOH C . 
F 3 HOH 17 317 54  HOH HOH C . 
F 3 HOH 18 318 119 HOH HOH C . 
F 3 HOH 19 319 132 HOH HOH C . 
F 3 HOH 20 320 171 HOH HOH C . 
F 3 HOH 21 321 20  HOH HOH C . 
F 3 HOH 22 322 50  HOH HOH C . 
F 3 HOH 23 323 9   HOH HOH C . 
F 3 HOH 24 324 143 HOH HOH C . 
F 3 HOH 25 325 76  HOH HOH C . 
F 3 HOH 26 326 43  HOH HOH C . 
F 3 HOH 27 327 56  HOH HOH C . 
F 3 HOH 28 328 87  HOH HOH C . 
F 3 HOH 29 329 182 HOH HOH C . 
F 3 HOH 30 330 5   HOH HOH C . 
F 3 HOH 31 331 17  HOH HOH C . 
F 3 HOH 32 332 106 HOH HOH C . 
F 3 HOH 33 333 184 HOH HOH C . 
F 3 HOH 34 334 47  HOH HOH C . 
F 3 HOH 35 335 90  HOH HOH C . 
F 3 HOH 36 336 197 HOH HOH C . 
F 3 HOH 37 337 42  HOH HOH C . 
F 3 HOH 38 338 109 HOH HOH C . 
F 3 HOH 39 339 72  HOH HOH C . 
F 3 HOH 40 340 179 HOH HOH C . 
F 3 HOH 41 341 67  HOH HOH C . 
F 3 HOH 42 342 172 HOH HOH C . 
F 3 HOH 43 343 138 HOH HOH C . 
F 3 HOH 44 344 84  HOH HOH C . 
F 3 HOH 45 345 125 HOH HOH C . 
F 3 HOH 46 346 58  HOH HOH C . 
F 3 HOH 47 347 80  HOH HOH C . 
F 3 HOH 48 348 11  HOH HOH C . 
F 3 HOH 49 349 153 HOH HOH C . 
F 3 HOH 50 350 32  HOH HOH C . 
F 3 HOH 51 351 97  HOH HOH C . 
F 3 HOH 52 352 64  HOH HOH C . 
F 3 HOH 53 353 156 HOH HOH C . 
F 3 HOH 54 354 86  HOH HOH C . 
F 3 HOH 55 355 114 HOH HOH C . 
F 3 HOH 56 356 187 HOH HOH C . 
F 3 HOH 57 357 135 HOH HOH C . 
F 3 HOH 58 358 12  HOH HOH C . 
F 3 HOH 59 359 66  HOH HOH C . 
F 3 HOH 60 360 98  HOH HOH C . 
F 3 HOH 61 361 63  HOH HOH C . 
F 3 HOH 62 362 53  HOH HOH C . 
F 3 HOH 63 363 108 HOH HOH C . 
F 3 HOH 64 364 103 HOH HOH C . 
F 3 HOH 65 365 164 HOH HOH C . 
F 3 HOH 66 366 169 HOH HOH C . 
F 3 HOH 67 367 49  HOH HOH C . 
F 3 HOH 68 368 110 HOH HOH C . 
F 3 HOH 69 369 95  HOH HOH C . 
F 3 HOH 70 370 70  HOH HOH C . 
F 3 HOH 71 371 158 HOH HOH C . 
F 3 HOH 72 372 141 HOH HOH C . 
F 3 HOH 73 373 165 HOH HOH C . 
F 3 HOH 74 374 104 HOH HOH C . 
F 3 HOH 75 375 160 HOH HOH C . 
F 3 HOH 76 376 168 HOH HOH C . 
F 3 HOH 77 377 193 HOH HOH C . 
F 3 HOH 78 378 48  HOH HOH C . 
F 3 HOH 79 379 102 HOH HOH C . 
F 3 HOH 80 380 116 HOH HOH C . 
F 3 HOH 81 381 161 HOH HOH C . 
F 3 HOH 82 382 78  HOH HOH C . 
F 3 HOH 83 383 128 HOH HOH C . 
F 3 HOH 84 384 194 HOH HOH C . 
F 3 HOH 85 385 117 HOH HOH C . 
G 3 HOH 1  301 75  HOH HOH A . 
G 3 HOH 2  302 173 HOH HOH A . 
G 3 HOH 3  303 3   HOH HOH A . 
G 3 HOH 4  304 151 HOH HOH A . 
G 3 HOH 5  305 68  HOH HOH A . 
G 3 HOH 6  306 105 HOH HOH A . 
G 3 HOH 7  307 100 HOH HOH A . 
G 3 HOH 8  308 107 HOH HOH A . 
G 3 HOH 9  309 6   HOH HOH A . 
G 3 HOH 10 310 26  HOH HOH A . 
G 3 HOH 11 311 89  HOH HOH A . 
G 3 HOH 12 312 65  HOH HOH A . 
G 3 HOH 13 313 166 HOH HOH A . 
G 3 HOH 14 314 2   HOH HOH A . 
G 3 HOH 15 315 157 HOH HOH A . 
G 3 HOH 16 316 22  HOH HOH A . 
G 3 HOH 17 317 79  HOH HOH A . 
G 3 HOH 18 318 30  HOH HOH A . 
G 3 HOH 19 319 14  HOH HOH A . 
G 3 HOH 20 320 118 HOH HOH A . 
G 3 HOH 21 321 93  HOH HOH A . 
G 3 HOH 22 322 122 HOH HOH A . 
G 3 HOH 23 323 36  HOH HOH A . 
G 3 HOH 24 324 69  HOH HOH A . 
G 3 HOH 25 325 94  HOH HOH A . 
G 3 HOH 26 326 27  HOH HOH A . 
G 3 HOH 27 327 142 HOH HOH A . 
G 3 HOH 28 328 59  HOH HOH A . 
G 3 HOH 29 329 40  HOH HOH A . 
G 3 HOH 30 330 35  HOH HOH A . 
G 3 HOH 31 331 159 HOH HOH A . 
G 3 HOH 32 332 101 HOH HOH A . 
G 3 HOH 33 333 82  HOH HOH A . 
G 3 HOH 34 334 113 HOH HOH A . 
G 3 HOH 35 335 4   HOH HOH A . 
G 3 HOH 36 336 129 HOH HOH A . 
G 3 HOH 37 337 121 HOH HOH A . 
G 3 HOH 38 338 120 HOH HOH A . 
G 3 HOH 39 339 13  HOH HOH A . 
G 3 HOH 40 340 34  HOH HOH A . 
G 3 HOH 41 341 149 HOH HOH A . 
G 3 HOH 42 342 136 HOH HOH A . 
G 3 HOH 43 343 10  HOH HOH A . 
G 3 HOH 44 344 88  HOH HOH A . 
G 3 HOH 45 345 45  HOH HOH A . 
G 3 HOH 46 346 130 HOH HOH A . 
G 3 HOH 47 347 144 HOH HOH A . 
G 3 HOH 48 348 73  HOH HOH A . 
G 3 HOH 49 349 139 HOH HOH A . 
G 3 HOH 50 350 178 HOH HOH A . 
G 3 HOH 51 351 196 HOH HOH A . 
G 3 HOH 52 352 57  HOH HOH A . 
G 3 HOH 53 353 71  HOH HOH A . 
G 3 HOH 54 354 148 HOH HOH A . 
G 3 HOH 55 355 147 HOH HOH A . 
G 3 HOH 56 356 177 HOH HOH A . 
G 3 HOH 57 357 155 HOH HOH A . 
G 3 HOH 58 358 154 HOH HOH A . 
G 3 HOH 59 359 163 HOH HOH A . 
H 3 HOH 1  201 191 HOH HOH B . 
H 3 HOH 2  202 192 HOH HOH B . 
H 3 HOH 3  203 190 HOH HOH B . 
H 3 HOH 4  204 1   HOH HOH B . 
H 3 HOH 5  205 85  HOH HOH B . 
H 3 HOH 6  206 83  HOH HOH B . 
H 3 HOH 7  207 137 HOH HOH B . 
H 3 HOH 8  208 188 HOH HOH B . 
H 3 HOH 9  209 21  HOH HOH B . 
H 3 HOH 10 210 61  HOH HOH B . 
H 3 HOH 11 211 195 HOH HOH B . 
H 3 HOH 12 212 81  HOH HOH B . 
H 3 HOH 13 213 140 HOH HOH B . 
H 3 HOH 14 214 33  HOH HOH B . 
H 3 HOH 15 215 92  HOH HOH B . 
H 3 HOH 16 216 39  HOH HOH B . 
H 3 HOH 17 217 16  HOH HOH B . 
H 3 HOH 18 218 37  HOH HOH B . 
H 3 HOH 19 219 23  HOH HOH B . 
H 3 HOH 20 220 62  HOH HOH B . 
H 3 HOH 21 221 77  HOH HOH B . 
H 3 HOH 22 222 51  HOH HOH B . 
H 3 HOH 23 223 183 HOH HOH B . 
H 3 HOH 24 224 29  HOH HOH B . 
H 3 HOH 25 225 145 HOH HOH B . 
H 3 HOH 26 226 174 HOH HOH B . 
H 3 HOH 27 227 60  HOH HOH B . 
H 3 HOH 28 228 111 HOH HOH B . 
H 3 HOH 29 229 176 HOH HOH B . 
H 3 HOH 30 230 44  HOH HOH B . 
H 3 HOH 31 231 96  HOH HOH B . 
H 3 HOH 32 232 41  HOH HOH B . 
H 3 HOH 33 233 19  HOH HOH B . 
H 3 HOH 34 234 24  HOH HOH B . 
H 3 HOH 35 235 55  HOH HOH B . 
H 3 HOH 36 236 8   HOH HOH B . 
H 3 HOH 37 237 25  HOH HOH B . 
H 3 HOH 38 238 7   HOH HOH B . 
H 3 HOH 39 239 126 HOH HOH B . 
H 3 HOH 40 240 112 HOH HOH B . 
H 3 HOH 41 241 131 HOH HOH B . 
H 3 HOH 42 242 99  HOH HOH B . 
H 3 HOH 43 243 74  HOH HOH B . 
H 3 HOH 44 244 52  HOH HOH B . 
H 3 HOH 45 245 162 HOH HOH B . 
H 3 HOH 46 246 175 HOH HOH B . 
H 3 HOH 47 247 123 HOH HOH B . 
H 3 HOH 48 248 167 HOH HOH B . 
H 3 HOH 49 249 150 HOH HOH B . 
H 3 HOH 50 250 181 HOH HOH B . 
H 3 HOH 51 251 152 HOH HOH B . 
H 3 HOH 52 252 124 HOH HOH B . 
H 3 HOH 53 253 127 HOH HOH B . 
H 3 HOH 54 254 91  HOH HOH B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 C ARG 36  ? CG  ? A ARG 19  CG  
2  1 Y 1 C ARG 36  ? CD  ? A ARG 19  CD  
3  1 Y 1 C ARG 36  ? NE  ? A ARG 19  NE  
4  1 Y 1 C ARG 36  ? CZ  ? A ARG 19  CZ  
5  1 Y 1 C ARG 36  ? NH1 ? A ARG 19  NH1 
6  1 Y 1 C ARG 36  ? NH2 ? A ARG 19  NH2 
7  1 Y 1 C VAL 57  ? CG1 ? A VAL 40  CG1 
8  1 Y 1 C VAL 57  ? CG2 ? A VAL 40  CG2 
9  1 Y 1 A MET 19  ? CG  ? B MET 2   CG  
10 1 Y 1 A MET 19  ? SD  ? B MET 2   SD  
11 1 Y 1 A MET 19  ? CE  ? B MET 2   CE  
12 1 Y 1 A ARG 36  ? CG  ? B ARG 19  CG  
13 1 Y 1 A ARG 36  ? CD  ? B ARG 19  CD  
14 1 Y 1 A ARG 36  ? NE  ? B ARG 19  NE  
15 1 Y 1 A ARG 36  ? CZ  ? B ARG 19  CZ  
16 1 Y 1 A ARG 36  ? NH1 ? B ARG 19  NH1 
17 1 Y 1 A ARG 36  ? NH2 ? B ARG 19  NH2 
18 1 Y 1 A GLU 55  ? CG  ? B GLU 38  CG  
19 1 Y 1 A GLU 55  ? CD  ? B GLU 38  CD  
20 1 Y 1 A GLU 55  ? OE1 ? B GLU 38  OE1 
21 1 Y 1 A GLU 55  ? OE2 ? B GLU 38  OE2 
22 1 Y 1 A HIS 56  ? CG  ? B HIS 39  CG  
23 1 Y 1 A HIS 56  ? ND1 ? B HIS 39  ND1 
24 1 Y 1 A HIS 56  ? CD2 ? B HIS 39  CD2 
25 1 Y 1 A HIS 56  ? CE1 ? B HIS 39  CE1 
26 1 Y 1 A HIS 56  ? NE2 ? B HIS 39  NE2 
27 1 Y 1 B ARG 33  ? CG  ? C ARG 16  CG  
28 1 Y 1 B ARG 33  ? CD  ? C ARG 16  CD  
29 1 Y 1 B ARG 33  ? NE  ? C ARG 16  NE  
30 1 Y 1 B ARG 33  ? CZ  ? C ARG 16  CZ  
31 1 Y 1 B ARG 33  ? NH1 ? C ARG 16  NH1 
32 1 Y 1 B ARG 33  ? NH2 ? C ARG 16  NH2 
33 1 Y 1 B VAL 57  ? CG1 ? C VAL 40  CG1 
34 1 Y 1 B VAL 57  ? CG2 ? C VAL 40  CG2 
35 1 Y 1 B GLU 78  ? CG  ? C GLU 61  CG  
36 1 Y 1 B GLU 78  ? CD  ? C GLU 61  CD  
37 1 Y 1 B GLU 78  ? OE1 ? C GLU 61  OE1 
38 1 Y 1 B GLU 78  ? OE2 ? C GLU 61  OE2 
39 1 Y 1 B ASP 161 ? CG  ? C ASP 144 CG  
40 1 Y 1 B ASP 161 ? OD1 ? C ASP 144 OD1 
41 1 Y 1 B ASP 161 ? OD2 ? C ASP 144 OD2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? '(1.20.1_4487: ???)' 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? DIALS   ? ? ? .                    2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .                    3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .                    4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   106.45 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8RPS 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     74.879 
_cell.length_a_esd                 ? 
_cell.length_b                     56.828 
_cell.length_b_esd                 ? 
_cell.length_c                     88.543 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        12 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8RPS 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'C 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8RPS 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             1.86 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          33.98 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              4.0 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '[25 mM sodium malonate, 37.5 mM imidazole and 37.5 mM boric acid] pH 4.0 and 15 % PEG 1500.' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293.15 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 X 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-07-09 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.6199 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'DIAMOND BEAMLINE I24' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.6199 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   I24 
_diffrn_source.pdbx_synchrotron_site       Diamond 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8RPS 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.75 
_reflns.d_resolution_low                               44.56 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     36132 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                5.7 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          8.4 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                0.102 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.99 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.102 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.75 
_reflns_shell.d_res_low                                     1.78 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           2.0 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1975 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               5.9 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               1.148 
_reflns_shell.pdbx_Rpim_I_all                               0.650 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.707 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          100.0 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.940 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8RPS 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.75 
_refine.ls_d_res_low                             42.46 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     36088 
_refine.ls_number_reflns_R_free                  1815 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.75 
_refine.ls_percent_reflns_R_free                 5.03 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1806 
_refine.ls_R_factor_R_free                       0.2039 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1794 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.36 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.10 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 21.38 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.20 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.pdbx_number_atoms_protein        3079 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         44 
_refine_hist.number_atoms_solvent             198 
_refine_hist.number_atoms_total               3321 
_refine_hist.d_res_high                       1.75 
_refine_hist.d_res_low                        42.46 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.007 ? ?   ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.971 ? ?   ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 6.542 ? 460 ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.054 ? 460 ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.018 ? 565 ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.75 1.80  . . 138 2565 99.00  . . . . 0.2432 . . . . . . . . . . . 0.2928 
'X-RAY DIFFRACTION' 1.80 1.85  . . 148 2620 100.00 . . . . 0.2209 . . . . . . . . . . . 0.2711 
'X-RAY DIFFRACTION' 1.85 1.91  . . 138 2607 99.00  . . . . 0.2607 . . . . . . . . . . . 0.3416 
'X-RAY DIFFRACTION' 1.91 1.98  . . 139 2638 100.00 . . . . 0.2095 . . . . . . . . . . . 0.2296 
'X-RAY DIFFRACTION' 1.98 2.06  . . 116 2660 100.00 . . . . 0.2039 . . . . . . . . . . . 0.2320 
'X-RAY DIFFRACTION' 2.06 2.15  . . 124 2640 100.00 . . . . 0.1909 . . . . . . . . . . . 0.2280 
'X-RAY DIFFRACTION' 2.15 2.26  . . 150 2612 99.00  . . . . 0.2066 . . . . . . . . . . . 0.2523 
'X-RAY DIFFRACTION' 2.26 2.40  . . 129 2622 100.00 . . . . 0.1793 . . . . . . . . . . . 0.2030 
'X-RAY DIFFRACTION' 2.40 2.59  . . 174 2629 100.00 . . . . 0.1749 . . . . . . . . . . . 0.1920 
'X-RAY DIFFRACTION' 2.59 2.85  . . 146 2621 100.00 . . . . 0.1770 . . . . . . . . . . . 0.2245 
'X-RAY DIFFRACTION' 2.85 3.26  . . 139 2653 100.00 . . . . 0.1724 . . . . . . . . . . . 0.1787 
'X-RAY DIFFRACTION' 3.26 4.11  . . 140 2671 100.00 . . . . 0.1558 . . . . . . . . . . . 0.1761 
'X-RAY DIFFRACTION' 4.11 42.46 . . 134 2735 100.00 . . . . 0.1630 . . . . . . . . . . . 0.1752 
# 
_struct.entry_id                     8RPS 
_struct.title                        'Crystal structure of human DNPH1 mutant- D80N bound to 5hmdUMP' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8RPS 
_struct_keywords.text            
;deoxyribonucleoside 5'-monophosphate N-glycosidase activity, HYDROLASE
;
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 1 ? 
D N N 2 ? 
E N N 2 ? 
F N N 3 ? 
G N N 3 ? 
H N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    DNPH1_HUMAN 
_struct_ref.pdbx_db_accession          O43598 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;RPALYFCGSIRGGREDRTLYERIVSRLRRFGTVLTEHVAAAELGARGEEAAGGDRLIHEQDLEWLQQADVVVAEVTQPSL
GVGYELGRAVAFNKRILCLFRPQSGRVLSAMIRGAADGSRFQVWDYEEGEVEALLDRYFEADP
;
_struct_ref.pdbx_align_begin           20 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8RPS C 3 ? 145 ? O43598 20 ? 162 ? 20 162 
2 1 8RPS A 3 ? 145 ? O43598 20 ? 162 ? 20 162 
3 1 8RPS B 3 ? 145 ? O43598 20 ? 162 ? 20 162 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8RPS GLY C 1  ? UNP O43598 ?   ?  'expression tag'      18 1 
1 8RPS MET C 2  ? UNP O43598 ?   ?  'expression tag'      19 2 
1 8RPS ASN C 63 ? UNP O43598 ASP 80 'engineered mutation' 80 3 
2 8RPS GLY A 1  ? UNP O43598 ?   ?  'expression tag'      18 4 
2 8RPS MET A 2  ? UNP O43598 ?   ?  'expression tag'      19 5 
2 8RPS ASN A 63 ? UNP O43598 ASP 80 'engineered mutation' 80 6 
3 8RPS GLY B 1  ? UNP O43598 ?   ?  'expression tag'      18 7 
3 8RPS MET B 2  ? UNP O43598 ?   ?  'expression tag'      19 8 
3 8RPS ASN B 63 ? UNP O43598 ASP 80 'engineered mutation' 80 9 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 software_defined_assembly PISA dimeric 2 
2 software_defined_assembly PISA dimeric 2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 4040  ? 
1 MORE         -34   ? 
1 'SSA (A^2)'  11530 ? 
2 'ABSA (A^2)' 3320  ? 
2 MORE         -32   ? 
2 'SSA (A^2)'  11690 ? 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1,2 A,D,F     
2 1   B,C,E,G,H 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z     1.0000000000  0.0000000000 0.0000000000 0.0000000000   0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000  
2 'crystal symmetry operation' 2_556 -x,y,-z+1 -1.0000000000 0.0000000000 0.0000000000 -25.0734746869 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 84.9186888507 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASP A 18  ? ARG A 30  ? ASP C 35  ARG C 47  1 ? 13 
HELX_P HELX_P2  AA2 GLY A 55  ? ALA A 70  ? GLY C 72  ALA C 87  1 ? 16 
HELX_P HELX_P3  AA3 SER A 81  ? PHE A 94  ? SER C 98  PHE C 111 1 ? 14 
HELX_P HELX_P4  AA4 SER A 111 ? GLY A 116 ? SER C 128 GLY C 133 1 ? 6  
HELX_P HELX_P5  AA5 GLU A 129 ? GLY A 131 ? GLU C 146 GLY C 148 5 ? 3  
HELX_P HELX_P6  AA6 GLU A 132 ? GLU A 142 ? GLU C 149 GLU C 159 1 ? 11 
HELX_P HELX_P7  AA7 ASP B 18  ? ARG B 30  ? ASP A 35  ARG A 47  1 ? 13 
HELX_P HELX_P8  AA8 GLY B 54  ? ALA B 70  ? GLY A 71  ALA A 87  1 ? 17 
HELX_P HELX_P9  AA9 SER B 81  ? PHE B 94  ? SER A 98  PHE A 111 1 ? 14 
HELX_P HELX_P10 AB1 ARG B 103 ? GLY B 107 ? ARG A 120 GLY A 124 5 ? 5  
HELX_P HELX_P11 AB2 SER B 111 ? GLY B 116 ? SER A 128 GLY A 133 1 ? 6  
HELX_P HELX_P12 AB3 GLU B 129 ? GLY B 131 ? GLU A 146 GLY A 148 5 ? 3  
HELX_P HELX_P13 AB4 GLU B 132 ? PHE B 141 ? GLU A 149 PHE A 158 1 ? 10 
HELX_P HELX_P14 AB5 GLY C 15  ? GLY C 33  ? GLY B 32  GLY B 50  1 ? 19 
HELX_P HELX_P15 AB6 ASP C 56  ? ALA C 70  ? ASP B 73  ALA B 87  1 ? 15 
HELX_P HELX_P16 AB7 SER C 81  ? PHE C 94  ? SER B 98  PHE B 111 1 ? 14 
HELX_P HELX_P17 AB8 ARG C 103 ? GLY C 107 ? ARG B 120 GLY B 124 5 ? 5  
HELX_P HELX_P18 AB9 SER C 111 ? GLY C 116 ? SER B 128 GLY B 133 1 ? 6  
HELX_P HELX_P19 AC1 GLU C 129 ? GLY C 131 ? GLU B 146 GLY B 148 5 ? 3  
HELX_P HELX_P20 AC2 GLU C 132 ? ASP C 144 ? GLU B 149 ASP B 161 1 ? 13 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 5 ? 
AA3 ? 5 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel 
AA1 2 3 ? parallel 
AA1 3 4 ? parallel 
AA1 4 5 ? parallel 
AA2 1 2 ? parallel 
AA2 2 3 ? parallel 
AA2 3 4 ? parallel 
AA2 4 5 ? parallel 
AA3 1 2 ? parallel 
AA3 2 3 ? parallel 
AA3 3 4 ? parallel 
AA3 4 5 ? parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 THR A 34  ? THR A 37  ? THR C 51  THR C 54  
AA1 2 ALA A 5   ? CYS A 9   ? ALA C 22  CYS C 26  
AA1 3 VAL A 72  ? GLU A 76  ? VAL C 89  GLU C 93  
AA1 4 ILE A 98  ? PHE A 102 ? ILE C 115 PHE C 119 
AA1 5 PHE A 123 ? ASP A 127 ? PHE C 140 ASP C 144 
AA2 1 THR B 34  ? VAL B 35  ? THR A 51  VAL A 52  
AA2 2 ALA B 5   ? CYS B 9   ? ALA A 22  CYS A 26  
AA2 3 VAL B 72  ? GLU B 76  ? VAL A 89  GLU A 93  
AA2 4 ARG B 97  ? PHE B 102 ? ARG A 114 PHE A 119 
AA2 5 PHE B 123 ? ASP B 127 ? PHE A 140 ASP A 144 
AA3 1 THR C 34  ? THR C 37  ? THR B 51  THR B 54  
AA3 2 ALA C 5   ? CYS C 9   ? ALA B 22  CYS B 26  
AA3 3 VAL C 72  ? GLU C 76  ? VAL B 89  GLU B 93  
AA3 4 ARG C 97  ? PHE C 102 ? ARG B 114 PHE B 119 
AA3 5 PHE C 123 ? ASP C 127 ? PHE B 140 ASP B 144 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O THR A 34  ? O THR C 51  N LEU A 6   ? N LEU C 23  
AA1 2 3 N TYR A 7   ? N TYR C 24  O VAL A 74  ? O VAL C 91  
AA1 3 4 N VAL A 73  ? N VAL C 90  O LEU A 99  ? O LEU C 116 
AA1 4 5 N CYS A 100 ? N CYS C 117 O GLN A 124 ? O GLN C 141 
AA2 1 2 O THR B 34  ? O THR A 51  N LEU B 6   ? N LEU A 23  
AA2 2 3 N TYR B 7   ? N TYR A 24  O VAL B 74  ? O VAL A 91  
AA2 3 4 N VAL B 73  ? N VAL A 90  O LEU B 99  ? O LEU A 116 
AA2 4 5 N CYS B 100 ? N CYS A 117 O GLN B 124 ? O GLN A 141 
AA3 1 2 O LEU C 36  ? O LEU B 53  N LEU C 6   ? N LEU B 23  
AA3 2 3 N CYS C 9   ? N CYS B 26  O VAL C 74  ? O VAL B 91  
AA3 3 4 N VAL C 73  ? N VAL B 90  O ARG C 97  ? O ARG B 114 
AA3 4 5 N CYS C 100 ? N CYS B 117 O GLN C 124 ? O GLN B 141 
# 
_pdbx_entry_details.entry_id                   8RPS 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ILE C 29  ? ? -134.38 -75.04  
2 1 SER C 128 ? ? -36.62  132.70  
3 1 SER C 138 ? ? -131.80 -80.43  
4 1 ILE A 29  ? ? -121.39 -72.42  
5 1 SER A 138 ? ? -128.74 -75.77  
6 1 ARG B 30  ? ? -165.33 -164.19 
7 1 SER B 128 ? ? -35.71  129.40  
8 1 SER B 138 ? ? -129.26 -80.92  
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 C GLY 18  ? A GLY 1   
2  1 Y 1 C ALA 59  ? A ALA 42  
3  1 Y 1 C ALA 60  ? A ALA 43  
4  1 Y 1 C GLU 61  ? A GLU 44  
5  1 Y 1 C LEU 62  ? A LEU 45  
6  1 Y 1 C GLY 63  ? A GLY 46  
7  1 Y 1 C ALA 64  ? A ALA 47  
8  1 Y 1 C ARG 65  ? A ARG 48  
9  1 Y 1 C GLY 66  ? A GLY 49  
10 1 Y 1 C GLU 67  ? A GLU 50  
11 1 Y 1 C GLU 68  ? A GLU 51  
12 1 Y 1 C ALA 69  ? A ALA 52  
13 1 Y 1 C ALA 70  ? A ALA 53  
14 1 Y 1 C ALA 160 ? A ALA 143 
15 1 Y 1 C ASP 161 ? A ASP 144 
16 1 Y 1 C PRO 162 ? A PRO 145 
17 1 Y 1 A VAL 57  ? B VAL 40  
18 1 Y 1 A ALA 58  ? B ALA 41  
19 1 Y 1 A ALA 59  ? B ALA 42  
20 1 Y 1 A ALA 60  ? B ALA 43  
21 1 Y 1 A GLU 61  ? B GLU 44  
22 1 Y 1 A LEU 62  ? B LEU 45  
23 1 Y 1 A GLY 63  ? B GLY 46  
24 1 Y 1 A ALA 64  ? B ALA 47  
25 1 Y 1 A ARG 65  ? B ARG 48  
26 1 Y 1 A GLY 66  ? B GLY 49  
27 1 Y 1 A GLU 67  ? B GLU 50  
28 1 Y 1 A GLU 68  ? B GLU 51  
29 1 Y 1 A ALA 69  ? B ALA 52  
30 1 Y 1 A ALA 160 ? B ALA 143 
31 1 Y 1 A ASP 161 ? B ASP 144 
32 1 Y 1 A PRO 162 ? B PRO 145 
33 1 Y 1 B ALA 58  ? C ALA 41  
34 1 Y 1 B ALA 59  ? C ALA 42  
35 1 Y 1 B ALA 60  ? C ALA 43  
36 1 Y 1 B GLU 61  ? C GLU 44  
37 1 Y 1 B LEU 62  ? C LEU 45  
38 1 Y 1 B GLY 63  ? C GLY 46  
39 1 Y 1 B ALA 64  ? C ALA 47  
40 1 Y 1 B ARG 65  ? C ARG 48  
41 1 Y 1 B GLY 66  ? C GLY 49  
42 1 Y 1 B GLU 67  ? C GLU 50  
43 1 Y 1 B GLU 68  ? C GLU 51  
44 1 Y 1 B ALA 69  ? C ALA 52  
45 1 Y 1 B ALA 70  ? C ALA 53  
46 1 Y 1 B GLY 71  ? C GLY 54  
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
5HU P      P N N 1   
5HU OP1    O N N 2   
5HU OP2    O N N 3   
5HU OP3    O N N 4   
5HU "O5'"  O N N 5   
5HU "C5'"  C N N 6   
5HU "C4'"  C N R 7   
5HU "O4'"  O N N 8   
5HU "C3'"  C N S 9   
5HU "O3'"  O N N 10  
5HU "C2'"  C N N 11  
5HU "C1'"  C N R 12  
5HU N1     N N N 13  
5HU C2     C N N 14  
5HU O2     O N N 15  
5HU N3     N N N 16  
5HU C4     C N N 17  
5HU O4     O N N 18  
5HU C5     C N N 19  
5HU C5A    C N N 20  
5HU C6     C N N 21  
5HU O5B    O N N 22  
5HU HO2P   H N N 23  
5HU HO3P   H N N 24  
5HU "H5'"  H N N 25  
5HU "H5''" H N N 26  
5HU "HC4'" H N N 27  
5HU "HC3'" H N N 28  
5HU "HO3'" H N N 29  
5HU "H2'"  H N N 30  
5HU "H2''" H N N 31  
5HU "HC1'" H N N 32  
5HU HN3    H N N 33  
5HU H5A1   H N N 34  
5HU H5A2   H N N 35  
5HU HC6    H N N 36  
5HU HO5B   H N N 37  
ALA N      N N N 38  
ALA CA     C N S 39  
ALA C      C N N 40  
ALA O      O N N 41  
ALA CB     C N N 42  
ALA OXT    O N N 43  
ALA H      H N N 44  
ALA H2     H N N 45  
ALA HA     H N N 46  
ALA HB1    H N N 47  
ALA HB2    H N N 48  
ALA HB3    H N N 49  
ALA HXT    H N N 50  
ARG N      N N N 51  
ARG CA     C N S 52  
ARG C      C N N 53  
ARG O      O N N 54  
ARG CB     C N N 55  
ARG CG     C N N 56  
ARG CD     C N N 57  
ARG NE     N N N 58  
ARG CZ     C N N 59  
ARG NH1    N N N 60  
ARG NH2    N N N 61  
ARG OXT    O N N 62  
ARG H      H N N 63  
ARG H2     H N N 64  
ARG HA     H N N 65  
ARG HB2    H N N 66  
ARG HB3    H N N 67  
ARG HG2    H N N 68  
ARG HG3    H N N 69  
ARG HD2    H N N 70  
ARG HD3    H N N 71  
ARG HE     H N N 72  
ARG HH11   H N N 73  
ARG HH12   H N N 74  
ARG HH21   H N N 75  
ARG HH22   H N N 76  
ARG HXT    H N N 77  
ASN N      N N N 78  
ASN CA     C N S 79  
ASN C      C N N 80  
ASN O      O N N 81  
ASN CB     C N N 82  
ASN CG     C N N 83  
ASN OD1    O N N 84  
ASN ND2    N N N 85  
ASN OXT    O N N 86  
ASN H      H N N 87  
ASN H2     H N N 88  
ASN HA     H N N 89  
ASN HB2    H N N 90  
ASN HB3    H N N 91  
ASN HD21   H N N 92  
ASN HD22   H N N 93  
ASN HXT    H N N 94  
ASP N      N N N 95  
ASP CA     C N S 96  
ASP C      C N N 97  
ASP O      O N N 98  
ASP CB     C N N 99  
ASP CG     C N N 100 
ASP OD1    O N N 101 
ASP OD2    O N N 102 
ASP OXT    O N N 103 
ASP H      H N N 104 
ASP H2     H N N 105 
ASP HA     H N N 106 
ASP HB2    H N N 107 
ASP HB3    H N N 108 
ASP HD2    H N N 109 
ASP HXT    H N N 110 
CYS N      N N N 111 
CYS CA     C N R 112 
CYS C      C N N 113 
CYS O      O N N 114 
CYS CB     C N N 115 
CYS SG     S N N 116 
CYS OXT    O N N 117 
CYS H      H N N 118 
CYS H2     H N N 119 
CYS HA     H N N 120 
CYS HB2    H N N 121 
CYS HB3    H N N 122 
CYS HG     H N N 123 
CYS HXT    H N N 124 
GLN N      N N N 125 
GLN CA     C N S 126 
GLN C      C N N 127 
GLN O      O N N 128 
GLN CB     C N N 129 
GLN CG     C N N 130 
GLN CD     C N N 131 
GLN OE1    O N N 132 
GLN NE2    N N N 133 
GLN OXT    O N N 134 
GLN H      H N N 135 
GLN H2     H N N 136 
GLN HA     H N N 137 
GLN HB2    H N N 138 
GLN HB3    H N N 139 
GLN HG2    H N N 140 
GLN HG3    H N N 141 
GLN HE21   H N N 142 
GLN HE22   H N N 143 
GLN HXT    H N N 144 
GLU N      N N N 145 
GLU CA     C N S 146 
GLU C      C N N 147 
GLU O      O N N 148 
GLU CB     C N N 149 
GLU CG     C N N 150 
GLU CD     C N N 151 
GLU OE1    O N N 152 
GLU OE2    O N N 153 
GLU OXT    O N N 154 
GLU H      H N N 155 
GLU H2     H N N 156 
GLU HA     H N N 157 
GLU HB2    H N N 158 
GLU HB3    H N N 159 
GLU HG2    H N N 160 
GLU HG3    H N N 161 
GLU HE2    H N N 162 
GLU HXT    H N N 163 
GLY N      N N N 164 
GLY CA     C N N 165 
GLY C      C N N 166 
GLY O      O N N 167 
GLY OXT    O N N 168 
GLY H      H N N 169 
GLY H2     H N N 170 
GLY HA2    H N N 171 
GLY HA3    H N N 172 
GLY HXT    H N N 173 
HIS N      N N N 174 
HIS CA     C N S 175 
HIS C      C N N 176 
HIS O      O N N 177 
HIS CB     C N N 178 
HIS CG     C Y N 179 
HIS ND1    N Y N 180 
HIS CD2    C Y N 181 
HIS CE1    C Y N 182 
HIS NE2    N Y N 183 
HIS OXT    O N N 184 
HIS H      H N N 185 
HIS H2     H N N 186 
HIS HA     H N N 187 
HIS HB2    H N N 188 
HIS HB3    H N N 189 
HIS HD1    H N N 190 
HIS HD2    H N N 191 
HIS HE1    H N N 192 
HIS HE2    H N N 193 
HIS HXT    H N N 194 
HOH O      O N N 195 
HOH H1     H N N 196 
HOH H2     H N N 197 
ILE N      N N N 198 
ILE CA     C N S 199 
ILE C      C N N 200 
ILE O      O N N 201 
ILE CB     C N S 202 
ILE CG1    C N N 203 
ILE CG2    C N N 204 
ILE CD1    C N N 205 
ILE OXT    O N N 206 
ILE H      H N N 207 
ILE H2     H N N 208 
ILE HA     H N N 209 
ILE HB     H N N 210 
ILE HG12   H N N 211 
ILE HG13   H N N 212 
ILE HG21   H N N 213 
ILE HG22   H N N 214 
ILE HG23   H N N 215 
ILE HD11   H N N 216 
ILE HD12   H N N 217 
ILE HD13   H N N 218 
ILE HXT    H N N 219 
LEU N      N N N 220 
LEU CA     C N S 221 
LEU C      C N N 222 
LEU O      O N N 223 
LEU CB     C N N 224 
LEU CG     C N N 225 
LEU CD1    C N N 226 
LEU CD2    C N N 227 
LEU OXT    O N N 228 
LEU H      H N N 229 
LEU H2     H N N 230 
LEU HA     H N N 231 
LEU HB2    H N N 232 
LEU HB3    H N N 233 
LEU HG     H N N 234 
LEU HD11   H N N 235 
LEU HD12   H N N 236 
LEU HD13   H N N 237 
LEU HD21   H N N 238 
LEU HD22   H N N 239 
LEU HD23   H N N 240 
LEU HXT    H N N 241 
LYS N      N N N 242 
LYS CA     C N S 243 
LYS C      C N N 244 
LYS O      O N N 245 
LYS CB     C N N 246 
LYS CG     C N N 247 
LYS CD     C N N 248 
LYS CE     C N N 249 
LYS NZ     N N N 250 
LYS OXT    O N N 251 
LYS H      H N N 252 
LYS H2     H N N 253 
LYS HA     H N N 254 
LYS HB2    H N N 255 
LYS HB3    H N N 256 
LYS HG2    H N N 257 
LYS HG3    H N N 258 
LYS HD2    H N N 259 
LYS HD3    H N N 260 
LYS HE2    H N N 261 
LYS HE3    H N N 262 
LYS HZ1    H N N 263 
LYS HZ2    H N N 264 
LYS HZ3    H N N 265 
LYS HXT    H N N 266 
MET N      N N N 267 
MET CA     C N S 268 
MET C      C N N 269 
MET O      O N N 270 
MET CB     C N N 271 
MET CG     C N N 272 
MET SD     S N N 273 
MET CE     C N N 274 
MET OXT    O N N 275 
MET H      H N N 276 
MET H2     H N N 277 
MET HA     H N N 278 
MET HB2    H N N 279 
MET HB3    H N N 280 
MET HG2    H N N 281 
MET HG3    H N N 282 
MET HE1    H N N 283 
MET HE2    H N N 284 
MET HE3    H N N 285 
MET HXT    H N N 286 
PHE N      N N N 287 
PHE CA     C N S 288 
PHE C      C N N 289 
PHE O      O N N 290 
PHE CB     C N N 291 
PHE CG     C Y N 292 
PHE CD1    C Y N 293 
PHE CD2    C Y N 294 
PHE CE1    C Y N 295 
PHE CE2    C Y N 296 
PHE CZ     C Y N 297 
PHE OXT    O N N 298 
PHE H      H N N 299 
PHE H2     H N N 300 
PHE HA     H N N 301 
PHE HB2    H N N 302 
PHE HB3    H N N 303 
PHE HD1    H N N 304 
PHE HD2    H N N 305 
PHE HE1    H N N 306 
PHE HE2    H N N 307 
PHE HZ     H N N 308 
PHE HXT    H N N 309 
PRO N      N N N 310 
PRO CA     C N S 311 
PRO C      C N N 312 
PRO O      O N N 313 
PRO CB     C N N 314 
PRO CG     C N N 315 
PRO CD     C N N 316 
PRO OXT    O N N 317 
PRO H      H N N 318 
PRO HA     H N N 319 
PRO HB2    H N N 320 
PRO HB3    H N N 321 
PRO HG2    H N N 322 
PRO HG3    H N N 323 
PRO HD2    H N N 324 
PRO HD3    H N N 325 
PRO HXT    H N N 326 
SER N      N N N 327 
SER CA     C N S 328 
SER C      C N N 329 
SER O      O N N 330 
SER CB     C N N 331 
SER OG     O N N 332 
SER OXT    O N N 333 
SER H      H N N 334 
SER H2     H N N 335 
SER HA     H N N 336 
SER HB2    H N N 337 
SER HB3    H N N 338 
SER HG     H N N 339 
SER HXT    H N N 340 
THR N      N N N 341 
THR CA     C N S 342 
THR C      C N N 343 
THR O      O N N 344 
THR CB     C N R 345 
THR OG1    O N N 346 
THR CG2    C N N 347 
THR OXT    O N N 348 
THR H      H N N 349 
THR H2     H N N 350 
THR HA     H N N 351 
THR HB     H N N 352 
THR HG1    H N N 353 
THR HG21   H N N 354 
THR HG22   H N N 355 
THR HG23   H N N 356 
THR HXT    H N N 357 
TRP N      N N N 358 
TRP CA     C N S 359 
TRP C      C N N 360 
TRP O      O N N 361 
TRP CB     C N N 362 
TRP CG     C Y N 363 
TRP CD1    C Y N 364 
TRP CD2    C Y N 365 
TRP NE1    N Y N 366 
TRP CE2    C Y N 367 
TRP CE3    C Y N 368 
TRP CZ2    C Y N 369 
TRP CZ3    C Y N 370 
TRP CH2    C Y N 371 
TRP OXT    O N N 372 
TRP H      H N N 373 
TRP H2     H N N 374 
TRP HA     H N N 375 
TRP HB2    H N N 376 
TRP HB3    H N N 377 
TRP HD1    H N N 378 
TRP HE1    H N N 379 
TRP HE3    H N N 380 
TRP HZ2    H N N 381 
TRP HZ3    H N N 382 
TRP HH2    H N N 383 
TRP HXT    H N N 384 
TYR N      N N N 385 
TYR CA     C N S 386 
TYR C      C N N 387 
TYR O      O N N 388 
TYR CB     C N N 389 
TYR CG     C Y N 390 
TYR CD1    C Y N 391 
TYR CD2    C Y N 392 
TYR CE1    C Y N 393 
TYR CE2    C Y N 394 
TYR CZ     C Y N 395 
TYR OH     O N N 396 
TYR OXT    O N N 397 
TYR H      H N N 398 
TYR H2     H N N 399 
TYR HA     H N N 400 
TYR HB2    H N N 401 
TYR HB3    H N N 402 
TYR HD1    H N N 403 
TYR HD2    H N N 404 
TYR HE1    H N N 405 
TYR HE2    H N N 406 
TYR HH     H N N 407 
TYR HXT    H N N 408 
VAL N      N N N 409 
VAL CA     C N S 410 
VAL C      C N N 411 
VAL O      O N N 412 
VAL CB     C N N 413 
VAL CG1    C N N 414 
VAL CG2    C N N 415 
VAL OXT    O N N 416 
VAL H      H N N 417 
VAL H2     H N N 418 
VAL HA     H N N 419 
VAL HB     H N N 420 
VAL HG11   H N N 421 
VAL HG12   H N N 422 
VAL HG13   H N N 423 
VAL HG21   H N N 424 
VAL HG22   H N N 425 
VAL HG23   H N N 426 
VAL HXT    H N N 427 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
5HU P     OP1    doub N N 1   
5HU P     OP2    sing N N 2   
5HU P     OP3    sing N N 3   
5HU P     "O5'"  sing N N 4   
5HU OP2   HO2P   sing N N 5   
5HU OP3   HO3P   sing N N 6   
5HU "O5'" "C5'"  sing N N 7   
5HU "C5'" "C4'"  sing N N 8   
5HU "C5'" "H5'"  sing N N 9   
5HU "C5'" "H5''" sing N N 10  
5HU "C4'" "O4'"  sing N N 11  
5HU "C4'" "C3'"  sing N N 12  
5HU "C4'" "HC4'" sing N N 13  
5HU "O4'" "C1'"  sing N N 14  
5HU "C3'" "O3'"  sing N N 15  
5HU "C3'" "C2'"  sing N N 16  
5HU "C3'" "HC3'" sing N N 17  
5HU "O3'" "HO3'" sing N N 18  
5HU "C2'" "C1'"  sing N N 19  
5HU "C2'" "H2'"  sing N N 20  
5HU "C2'" "H2''" sing N N 21  
5HU "C1'" N1     sing N N 22  
5HU "C1'" "HC1'" sing N N 23  
5HU N1    C2     sing N N 24  
5HU N1    C6     sing N N 25  
5HU C2    O2     doub N N 26  
5HU C2    N3     sing N N 27  
5HU N3    C4     sing N N 28  
5HU N3    HN3    sing N N 29  
5HU C4    O4     doub N N 30  
5HU C4    C5     sing N N 31  
5HU C5    C5A    sing N N 32  
5HU C5    C6     doub N N 33  
5HU C5A   O5B    sing N N 34  
5HU C5A   H5A1   sing N N 35  
5HU C5A   H5A2   sing N N 36  
5HU C6    HC6    sing N N 37  
5HU O5B   HO5B   sing N N 38  
ALA N     CA     sing N N 39  
ALA N     H      sing N N 40  
ALA N     H2     sing N N 41  
ALA CA    C      sing N N 42  
ALA CA    CB     sing N N 43  
ALA CA    HA     sing N N 44  
ALA C     O      doub N N 45  
ALA C     OXT    sing N N 46  
ALA CB    HB1    sing N N 47  
ALA CB    HB2    sing N N 48  
ALA CB    HB3    sing N N 49  
ALA OXT   HXT    sing N N 50  
ARG N     CA     sing N N 51  
ARG N     H      sing N N 52  
ARG N     H2     sing N N 53  
ARG CA    C      sing N N 54  
ARG CA    CB     sing N N 55  
ARG CA    HA     sing N N 56  
ARG C     O      doub N N 57  
ARG C     OXT    sing N N 58  
ARG CB    CG     sing N N 59  
ARG CB    HB2    sing N N 60  
ARG CB    HB3    sing N N 61  
ARG CG    CD     sing N N 62  
ARG CG    HG2    sing N N 63  
ARG CG    HG3    sing N N 64  
ARG CD    NE     sing N N 65  
ARG CD    HD2    sing N N 66  
ARG CD    HD3    sing N N 67  
ARG NE    CZ     sing N N 68  
ARG NE    HE     sing N N 69  
ARG CZ    NH1    sing N N 70  
ARG CZ    NH2    doub N N 71  
ARG NH1   HH11   sing N N 72  
ARG NH1   HH12   sing N N 73  
ARG NH2   HH21   sing N N 74  
ARG NH2   HH22   sing N N 75  
ARG OXT   HXT    sing N N 76  
ASN N     CA     sing N N 77  
ASN N     H      sing N N 78  
ASN N     H2     sing N N 79  
ASN CA    C      sing N N 80  
ASN CA    CB     sing N N 81  
ASN CA    HA     sing N N 82  
ASN C     O      doub N N 83  
ASN C     OXT    sing N N 84  
ASN CB    CG     sing N N 85  
ASN CB    HB2    sing N N 86  
ASN CB    HB3    sing N N 87  
ASN CG    OD1    doub N N 88  
ASN CG    ND2    sing N N 89  
ASN ND2   HD21   sing N N 90  
ASN ND2   HD22   sing N N 91  
ASN OXT   HXT    sing N N 92  
ASP N     CA     sing N N 93  
ASP N     H      sing N N 94  
ASP N     H2     sing N N 95  
ASP CA    C      sing N N 96  
ASP CA    CB     sing N N 97  
ASP CA    HA     sing N N 98  
ASP C     O      doub N N 99  
ASP C     OXT    sing N N 100 
ASP CB    CG     sing N N 101 
ASP CB    HB2    sing N N 102 
ASP CB    HB3    sing N N 103 
ASP CG    OD1    doub N N 104 
ASP CG    OD2    sing N N 105 
ASP OD2   HD2    sing N N 106 
ASP OXT   HXT    sing N N 107 
CYS N     CA     sing N N 108 
CYS N     H      sing N N 109 
CYS N     H2     sing N N 110 
CYS CA    C      sing N N 111 
CYS CA    CB     sing N N 112 
CYS CA    HA     sing N N 113 
CYS C     O      doub N N 114 
CYS C     OXT    sing N N 115 
CYS CB    SG     sing N N 116 
CYS CB    HB2    sing N N 117 
CYS CB    HB3    sing N N 118 
CYS SG    HG     sing N N 119 
CYS OXT   HXT    sing N N 120 
GLN N     CA     sing N N 121 
GLN N     H      sing N N 122 
GLN N     H2     sing N N 123 
GLN CA    C      sing N N 124 
GLN CA    CB     sing N N 125 
GLN CA    HA     sing N N 126 
GLN C     O      doub N N 127 
GLN C     OXT    sing N N 128 
GLN CB    CG     sing N N 129 
GLN CB    HB2    sing N N 130 
GLN CB    HB3    sing N N 131 
GLN CG    CD     sing N N 132 
GLN CG    HG2    sing N N 133 
GLN CG    HG3    sing N N 134 
GLN CD    OE1    doub N N 135 
GLN CD    NE2    sing N N 136 
GLN NE2   HE21   sing N N 137 
GLN NE2   HE22   sing N N 138 
GLN OXT   HXT    sing N N 139 
GLU N     CA     sing N N 140 
GLU N     H      sing N N 141 
GLU N     H2     sing N N 142 
GLU CA    C      sing N N 143 
GLU CA    CB     sing N N 144 
GLU CA    HA     sing N N 145 
GLU C     O      doub N N 146 
GLU C     OXT    sing N N 147 
GLU CB    CG     sing N N 148 
GLU CB    HB2    sing N N 149 
GLU CB    HB3    sing N N 150 
GLU CG    CD     sing N N 151 
GLU CG    HG2    sing N N 152 
GLU CG    HG3    sing N N 153 
GLU CD    OE1    doub N N 154 
GLU CD    OE2    sing N N 155 
GLU OE2   HE2    sing N N 156 
GLU OXT   HXT    sing N N 157 
GLY N     CA     sing N N 158 
GLY N     H      sing N N 159 
GLY N     H2     sing N N 160 
GLY CA    C      sing N N 161 
GLY CA    HA2    sing N N 162 
GLY CA    HA3    sing N N 163 
GLY C     O      doub N N 164 
GLY C     OXT    sing N N 165 
GLY OXT   HXT    sing N N 166 
HIS N     CA     sing N N 167 
HIS N     H      sing N N 168 
HIS N     H2     sing N N 169 
HIS CA    C      sing N N 170 
HIS CA    CB     sing N N 171 
HIS CA    HA     sing N N 172 
HIS C     O      doub N N 173 
HIS C     OXT    sing N N 174 
HIS CB    CG     sing N N 175 
HIS CB    HB2    sing N N 176 
HIS CB    HB3    sing N N 177 
HIS CG    ND1    sing Y N 178 
HIS CG    CD2    doub Y N 179 
HIS ND1   CE1    doub Y N 180 
HIS ND1   HD1    sing N N 181 
HIS CD2   NE2    sing Y N 182 
HIS CD2   HD2    sing N N 183 
HIS CE1   NE2    sing Y N 184 
HIS CE1   HE1    sing N N 185 
HIS NE2   HE2    sing N N 186 
HIS OXT   HXT    sing N N 187 
HOH O     H1     sing N N 188 
HOH O     H2     sing N N 189 
ILE N     CA     sing N N 190 
ILE N     H      sing N N 191 
ILE N     H2     sing N N 192 
ILE CA    C      sing N N 193 
ILE CA    CB     sing N N 194 
ILE CA    HA     sing N N 195 
ILE C     O      doub N N 196 
ILE C     OXT    sing N N 197 
ILE CB    CG1    sing N N 198 
ILE CB    CG2    sing N N 199 
ILE CB    HB     sing N N 200 
ILE CG1   CD1    sing N N 201 
ILE CG1   HG12   sing N N 202 
ILE CG1   HG13   sing N N 203 
ILE CG2   HG21   sing N N 204 
ILE CG2   HG22   sing N N 205 
ILE CG2   HG23   sing N N 206 
ILE CD1   HD11   sing N N 207 
ILE CD1   HD12   sing N N 208 
ILE CD1   HD13   sing N N 209 
ILE OXT   HXT    sing N N 210 
LEU N     CA     sing N N 211 
LEU N     H      sing N N 212 
LEU N     H2     sing N N 213 
LEU CA    C      sing N N 214 
LEU CA    CB     sing N N 215 
LEU CA    HA     sing N N 216 
LEU C     O      doub N N 217 
LEU C     OXT    sing N N 218 
LEU CB    CG     sing N N 219 
LEU CB    HB2    sing N N 220 
LEU CB    HB3    sing N N 221 
LEU CG    CD1    sing N N 222 
LEU CG    CD2    sing N N 223 
LEU CG    HG     sing N N 224 
LEU CD1   HD11   sing N N 225 
LEU CD1   HD12   sing N N 226 
LEU CD1   HD13   sing N N 227 
LEU CD2   HD21   sing N N 228 
LEU CD2   HD22   sing N N 229 
LEU CD2   HD23   sing N N 230 
LEU OXT   HXT    sing N N 231 
LYS N     CA     sing N N 232 
LYS N     H      sing N N 233 
LYS N     H2     sing N N 234 
LYS CA    C      sing N N 235 
LYS CA    CB     sing N N 236 
LYS CA    HA     sing N N 237 
LYS C     O      doub N N 238 
LYS C     OXT    sing N N 239 
LYS CB    CG     sing N N 240 
LYS CB    HB2    sing N N 241 
LYS CB    HB3    sing N N 242 
LYS CG    CD     sing N N 243 
LYS CG    HG2    sing N N 244 
LYS CG    HG3    sing N N 245 
LYS CD    CE     sing N N 246 
LYS CD    HD2    sing N N 247 
LYS CD    HD3    sing N N 248 
LYS CE    NZ     sing N N 249 
LYS CE    HE2    sing N N 250 
LYS CE    HE3    sing N N 251 
LYS NZ    HZ1    sing N N 252 
LYS NZ    HZ2    sing N N 253 
LYS NZ    HZ3    sing N N 254 
LYS OXT   HXT    sing N N 255 
MET N     CA     sing N N 256 
MET N     H      sing N N 257 
MET N     H2     sing N N 258 
MET CA    C      sing N N 259 
MET CA    CB     sing N N 260 
MET CA    HA     sing N N 261 
MET C     O      doub N N 262 
MET C     OXT    sing N N 263 
MET CB    CG     sing N N 264 
MET CB    HB2    sing N N 265 
MET CB    HB3    sing N N 266 
MET CG    SD     sing N N 267 
MET CG    HG2    sing N N 268 
MET CG    HG3    sing N N 269 
MET SD    CE     sing N N 270 
MET CE    HE1    sing N N 271 
MET CE    HE2    sing N N 272 
MET CE    HE3    sing N N 273 
MET OXT   HXT    sing N N 274 
PHE N     CA     sing N N 275 
PHE N     H      sing N N 276 
PHE N     H2     sing N N 277 
PHE CA    C      sing N N 278 
PHE CA    CB     sing N N 279 
PHE CA    HA     sing N N 280 
PHE C     O      doub N N 281 
PHE C     OXT    sing N N 282 
PHE CB    CG     sing N N 283 
PHE CB    HB2    sing N N 284 
PHE CB    HB3    sing N N 285 
PHE CG    CD1    doub Y N 286 
PHE CG    CD2    sing Y N 287 
PHE CD1   CE1    sing Y N 288 
PHE CD1   HD1    sing N N 289 
PHE CD2   CE2    doub Y N 290 
PHE CD2   HD2    sing N N 291 
PHE CE1   CZ     doub Y N 292 
PHE CE1   HE1    sing N N 293 
PHE CE2   CZ     sing Y N 294 
PHE CE2   HE2    sing N N 295 
PHE CZ    HZ     sing N N 296 
PHE OXT   HXT    sing N N 297 
PRO N     CA     sing N N 298 
PRO N     CD     sing N N 299 
PRO N     H      sing N N 300 
PRO CA    C      sing N N 301 
PRO CA    CB     sing N N 302 
PRO CA    HA     sing N N 303 
PRO C     O      doub N N 304 
PRO C     OXT    sing N N 305 
PRO CB    CG     sing N N 306 
PRO CB    HB2    sing N N 307 
PRO CB    HB3    sing N N 308 
PRO CG    CD     sing N N 309 
PRO CG    HG2    sing N N 310 
PRO CG    HG3    sing N N 311 
PRO CD    HD2    sing N N 312 
PRO CD    HD3    sing N N 313 
PRO OXT   HXT    sing N N 314 
SER N     CA     sing N N 315 
SER N     H      sing N N 316 
SER N     H2     sing N N 317 
SER CA    C      sing N N 318 
SER CA    CB     sing N N 319 
SER CA    HA     sing N N 320 
SER C     O      doub N N 321 
SER C     OXT    sing N N 322 
SER CB    OG     sing N N 323 
SER CB    HB2    sing N N 324 
SER CB    HB3    sing N N 325 
SER OG    HG     sing N N 326 
SER OXT   HXT    sing N N 327 
THR N     CA     sing N N 328 
THR N     H      sing N N 329 
THR N     H2     sing N N 330 
THR CA    C      sing N N 331 
THR CA    CB     sing N N 332 
THR CA    HA     sing N N 333 
THR C     O      doub N N 334 
THR C     OXT    sing N N 335 
THR CB    OG1    sing N N 336 
THR CB    CG2    sing N N 337 
THR CB    HB     sing N N 338 
THR OG1   HG1    sing N N 339 
THR CG2   HG21   sing N N 340 
THR CG2   HG22   sing N N 341 
THR CG2   HG23   sing N N 342 
THR OXT   HXT    sing N N 343 
TRP N     CA     sing N N 344 
TRP N     H      sing N N 345 
TRP N     H2     sing N N 346 
TRP CA    C      sing N N 347 
TRP CA    CB     sing N N 348 
TRP CA    HA     sing N N 349 
TRP C     O      doub N N 350 
TRP C     OXT    sing N N 351 
TRP CB    CG     sing N N 352 
TRP CB    HB2    sing N N 353 
TRP CB    HB3    sing N N 354 
TRP CG    CD1    doub Y N 355 
TRP CG    CD2    sing Y N 356 
TRP CD1   NE1    sing Y N 357 
TRP CD1   HD1    sing N N 358 
TRP CD2   CE2    doub Y N 359 
TRP CD2   CE3    sing Y N 360 
TRP NE1   CE2    sing Y N 361 
TRP NE1   HE1    sing N N 362 
TRP CE2   CZ2    sing Y N 363 
TRP CE3   CZ3    doub Y N 364 
TRP CE3   HE3    sing N N 365 
TRP CZ2   CH2    doub Y N 366 
TRP CZ2   HZ2    sing N N 367 
TRP CZ3   CH2    sing Y N 368 
TRP CZ3   HZ3    sing N N 369 
TRP CH2   HH2    sing N N 370 
TRP OXT   HXT    sing N N 371 
TYR N     CA     sing N N 372 
TYR N     H      sing N N 373 
TYR N     H2     sing N N 374 
TYR CA    C      sing N N 375 
TYR CA    CB     sing N N 376 
TYR CA    HA     sing N N 377 
TYR C     O      doub N N 378 
TYR C     OXT    sing N N 379 
TYR CB    CG     sing N N 380 
TYR CB    HB2    sing N N 381 
TYR CB    HB3    sing N N 382 
TYR CG    CD1    doub Y N 383 
TYR CG    CD2    sing Y N 384 
TYR CD1   CE1    sing Y N 385 
TYR CD1   HD1    sing N N 386 
TYR CD2   CE2    doub Y N 387 
TYR CD2   HD2    sing N N 388 
TYR CE1   CZ     doub Y N 389 
TYR CE1   HE1    sing N N 390 
TYR CE2   CZ     sing Y N 391 
TYR CE2   HE2    sing N N 392 
TYR CZ    OH     sing N N 393 
TYR OH    HH     sing N N 394 
TYR OXT   HXT    sing N N 395 
VAL N     CA     sing N N 396 
VAL N     H      sing N N 397 
VAL N     H2     sing N N 398 
VAL CA    C      sing N N 399 
VAL CA    CB     sing N N 400 
VAL CA    HA     sing N N 401 
VAL C     O      doub N N 402 
VAL C     OXT    sing N N 403 
VAL CB    CG1    sing N N 404 
VAL CB    CG2    sing N N 405 
VAL CB    HB     sing N N 406 
VAL CG1   HG11   sing N N 407 
VAL CG1   HG12   sing N N 408 
VAL CG1   HG13   sing N N 409 
VAL CG2   HG21   sing N N 410 
VAL CG2   HG22   sing N N 411 
VAL CG2   HG23   sing N N 412 
VAL OXT   HXT    sing N N 413 
# 
_pdbx_audit_support.funding_organization   'Other private' 
_pdbx_audit_support.country                'United Kingdom' 
_pdbx_audit_support.grant_number           'IBioIC 2021-01-01' 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   8OS9 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8RPS 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.013355 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.003943 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.017597 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.011776 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
P 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N     . MET A 1 2   ? -33.996 17.791  30.042 1.00 47.76 ? 19  MET C N     1 
ATOM   2    C CA    . MET A 1 2   ? -35.148 17.111  29.391 1.00 42.88 ? 19  MET C CA    1 
ATOM   3    C C     . MET A 1 2   ? -35.592 15.911  30.232 1.00 39.83 ? 19  MET C C     1 
ATOM   4    O O     . MET A 1 2   ? -36.802 15.721  30.376 1.00 38.02 ? 19  MET C O     1 
ATOM   5    C CB    . MET A 1 2   ? -34.797 16.636  27.981 1.00 47.73 ? 19  MET C CB    1 
ATOM   6    C CG    . MET A 1 2   ? -35.866 15.774  27.354 1.00 53.10 ? 19  MET C CG    1 
ATOM   7    S SD    . MET A 1 2   ? -36.705 16.668  26.029 1.00 93.25 ? 19  MET C SD    1 
ATOM   8    C CE    . MET A 1 2   ? -35.581 18.047  25.812 1.00 58.83 ? 19  MET C CE    1 
ATOM   9    N N     . ARG A 1 3   ? -34.651 15.102  30.722 1.00 34.93 ? 20  ARG C N     1 
ATOM   10   C CA    . ARG A 1 3   ? -35.070 13.950  31.561 1.00 36.07 ? 20  ARG C CA    1 
ATOM   11   C C     . ARG A 1 3   ? -34.039 13.656  32.654 1.00 36.17 ? 20  ARG C C     1 
ATOM   12   O O     . ARG A 1 3   ? -32.856 13.923  32.430 1.00 31.32 ? 20  ARG C O     1 
ATOM   13   C CB    . ARG A 1 3   ? -35.323 12.719  30.690 1.00 30.00 ? 20  ARG C CB    1 
ATOM   14   C CG    . ARG A 1 3   ? -36.784 12.310  30.610 1.00 30.00 ? 20  ARG C CG    1 
ATOM   15   C CD    . ARG A 1 3   ? -36.918 11.032  29.813 1.00 30.00 ? 20  ARG C CD    1 
ATOM   16   N NE    . ARG A 1 3   ? -36.904 9.826   30.626 1.00 30.00 ? 20  ARG C NE    1 
ATOM   17   C CZ    . ARG A 1 3   ? -37.806 9.537   31.553 1.00 30.00 ? 20  ARG C CZ    1 
ATOM   18   N NH1   . ARG A 1 3   ? -38.789 10.382  31.806 1.00 30.00 ? 20  ARG C NH1   1 
ATOM   19   N NH2   . ARG A 1 3   ? -37.719 8.409   32.231 1.00 30.00 ? 20  ARG C NH2   1 
ATOM   20   N N     . PRO A 1 4   ? -34.459 13.116  33.820 1.00 36.47 ? 21  PRO C N     1 
ATOM   21   C CA    . PRO A 1 4   ? -33.535 12.752  34.888 1.00 32.78 ? 21  PRO C CA    1 
ATOM   22   C C     . PRO A 1 4   ? -32.654 11.610  34.367 1.00 30.34 ? 21  PRO C C     1 
ATOM   23   O O     . PRO A 1 4   ? -33.171 10.735  33.737 1.00 33.20 ? 21  PRO C O     1 
ATOM   24   C CB    . PRO A 1 4   ? -34.443 12.212  36.003 1.00 36.84 ? 21  PRO C CB    1 
ATOM   25   C CG    . PRO A 1 4   ? -35.810 12.763  35.679 1.00 37.08 ? 21  PRO C CG    1 
ATOM   26   C CD    . PRO A 1 4   ? -35.851 12.849  34.171 1.00 39.27 ? 21  PRO C CD    1 
ATOM   27   N N     . ALA A 1 5   ? -31.359 11.646  34.671 1.00 30.51 ? 22  ALA C N     1 
ATOM   28   C CA    . ALA A 1 5   ? -30.438 10.601  34.176 1.00 30.31 ? 22  ALA C CA    1 
ATOM   29   C C     . ALA A 1 5   ? -29.912 9.778   35.352 1.00 24.02 ? 22  ALA C C     1 
ATOM   30   O O     . ALA A 1 5   ? -29.454 10.372  36.326 1.00 26.99 ? 22  ALA C O     1 
ATOM   31   C CB    . ALA A 1 5   ? -29.311 11.237  33.407 1.00 26.59 ? 22  ALA C CB    1 
ATOM   32   N N     . LEU A 1 6   ? -29.992 8.456   35.228 1.00 24.32 ? 23  LEU C N     1 
ATOM   33   C CA    . LEU A 1 6   ? -29.502 7.530   36.277 1.00 22.84 ? 23  LEU C CA    1 
ATOM   34   C C     . LEU A 1 6   ? -28.311 6.754   35.720 1.00 20.71 ? 23  LEU C C     1 
ATOM   35   O O     . LEU A 1 6   ? -28.484 6.060   34.733 1.00 23.57 ? 23  LEU C O     1 
ATOM   36   C CB    . LEU A 1 6   ? -30.620 6.552   36.643 1.00 24.23 ? 23  LEU C CB    1 
ATOM   37   C CG    . LEU A 1 6   ? -31.956 7.181   37.024 1.00 29.38 ? 23  LEU C CG    1 
ATOM   38   C CD1   . LEU A 1 6   ? -32.937 6.112   37.464 1.00 29.97 ? 23  LEU C CD1   1 
ATOM   39   C CD2   . LEU A 1 6   ? -31.766 8.215   38.115 1.00 30.30 ? 23  LEU C CD2   1 
ATOM   40   N N     . TYR A 1 7   ? -27.145 6.902   36.337 1.00 19.87 ? 24  TYR C N     1 
ATOM   41   C CA    . TYR A 1 7   ? -25.980 6.138   35.911 1.00 21.53 ? 24  TYR C CA    1 
ATOM   42   C C     . TYR A 1 7   ? -25.929 4.815   36.667 1.00 22.20 ? 24  TYR C C     1 
ATOM   43   O O     . TYR A 1 7   ? -26.001 4.802   37.900 1.00 22.21 ? 24  TYR C O     1 
ATOM   44   C CB    . TYR A 1 7   ? -24.705 6.942   36.155 1.00 20.02 ? 24  TYR C CB    1 
ATOM   45   C CG    . TYR A 1 7   ? -23.465 6.187   35.820 1.00 20.31 ? 24  TYR C CG    1 
ATOM   46   C CD1   . TYR A 1 7   ? -23.173 5.847   34.510 1.00 24.83 ? 24  TYR C CD1   1 
ATOM   47   C CD2   . TYR A 1 7   ? -22.580 5.797   36.816 1.00 26.06 ? 24  TYR C CD2   1 
ATOM   48   C CE1   . TYR A 1 7   ? -22.011 5.132   34.196 1.00 22.74 ? 24  TYR C CE1   1 
ATOM   49   C CE2   . TYR A 1 7   ? -21.430 5.092   36.517 1.00 23.53 ? 24  TYR C CE2   1 
ATOM   50   C CZ    . TYR A 1 7   ? -21.149 4.768   35.212 1.00 24.66 ? 24  TYR C CZ    1 
ATOM   51   O OH    . TYR A 1 7   ? -20.008 4.063   34.927 1.00 29.04 ? 24  TYR C OH    1 
ATOM   52   N N     . PHE A 1 8   ? -25.817 3.703   35.944 1.00 18.44 ? 25  PHE C N     1 
ATOM   53   C CA    . PHE A 1 8   ? -25.689 2.407   36.593 1.00 18.64 ? 25  PHE C CA    1 
ATOM   54   C C     . PHE A 1 8   ? -24.317 1.796   36.330 1.00 22.23 ? 25  PHE C C     1 
ATOM   55   O O     . PHE A 1 8   ? -23.844 1.788   35.193 1.00 22.54 ? 25  PHE C O     1 
ATOM   56   C CB    . PHE A 1 8   ? -26.734 1.395   36.142 1.00 24.53 ? 25  PHE C CB    1 
ATOM   57   C CG    . PHE A 1 8   ? -26.516 0.038   36.762 1.00 23.00 ? 25  PHE C CG    1 
ATOM   58   C CD1   . PHE A 1 8   ? -26.805 -0.175  38.110 1.00 19.59 ? 25  PHE C CD1   1 
ATOM   59   C CD2   . PHE A 1 8   ? -25.954 -0.997  36.030 1.00 24.06 ? 25  PHE C CD2   1 
ATOM   60   C CE1   . PHE A 1 8   ? -26.573 -1.400  38.694 1.00 20.51 ? 25  PHE C CE1   1 
ATOM   61   C CE2   . PHE A 1 8   ? -25.714 -2.223  36.608 1.00 26.29 ? 25  PHE C CE2   1 
ATOM   62   C CZ    . PHE A 1 8   ? -26.029 -2.429  37.951 1.00 25.25 ? 25  PHE C CZ    1 
ATOM   63   N N     . CYS A 1 9   ? -23.677 1.287   37.383 1.00 19.50 ? 26  CYS C N     1 
ATOM   64   C CA    . CYS A 1 9   ? -22.383 0.597   37.180 1.00 21.36 ? 26  CYS C CA    1 
ATOM   65   C C     . CYS A 1 9   ? -22.319 -0.743  37.912 1.00 20.61 ? 26  CYS C C     1 
ATOM   66   O O     . CYS A 1 9   ? -22.774 -0.831  39.062 1.00 20.62 ? 26  CYS C O     1 
ATOM   67   C CB    . CYS A 1 9   ? -21.165 1.394   37.620 1.00 25.70 ? 26  CYS C CB    1 
ATOM   68   S SG    . CYS A 1 9   ? -21.351 2.334   39.145 1.00 27.40 ? 26  CYS C SG    1 
ATOM   69   N N     . GLY A 1 10  ? -21.755 -1.723  37.231 1.00 17.90 ? 27  GLY C N     1 
ATOM   70   C CA    . GLY A 1 10  ? -21.572 -3.042  37.820 1.00 19.20 ? 27  GLY C CA    1 
ATOM   71   C C     . GLY A 1 10  ? -20.289 -3.629  37.290 1.00 20.57 ? 27  GLY C C     1 
ATOM   72   O O     . GLY A 1 10  ? -19.751 -3.086  36.325 1.00 21.24 ? 27  GLY C O     1 
ATOM   73   N N     . SER A 1 11  ? -19.823 -4.700  37.908 1.00 16.89 ? 28  SER C N     1 
ATOM   74   C CA    . SER A 1 11  ? -18.541 -5.311  37.508 1.00 18.05 ? 28  SER C CA    1 
ATOM   75   C C     . SER A 1 11  ? -18.599 -5.819  36.067 1.00 21.27 ? 28  SER C C     1 
ATOM   76   O O     . SER A 1 11  ? -19.671 -6.202  35.649 1.00 22.26 ? 28  SER C O     1 
ATOM   77   C CB    . SER A 1 11  ? -18.214 -6.462  38.410 1.00 18.01 ? 28  SER C CB    1 
ATOM   78   O OG    . SER A 1 11  ? -17.047 -7.148  37.988 1.00 21.36 ? 28  SER C OG    1 
ATOM   79   N N     . ILE A 1 12  ? -17.457 -5.853  35.390 1.00 18.25 ? 29  ILE C N     1 
ATOM   80   C CA    . ILE A 1 12  ? -17.351 -6.473  34.041 1.00 19.88 ? 29  ILE C CA    1 
ATOM   81   C C     . ILE A 1 12  ? -16.083 -7.332  34.078 1.00 21.63 ? 29  ILE C C     1 
ATOM   82   O O     . ILE A 1 12  ? -16.206 -8.540  34.240 1.00 23.49 ? 29  ILE C O     1 
ATOM   83   C CB    . ILE A 1 12  ? -17.338 -5.429  32.912 1.00 19.00 ? 29  ILE C CB    1 
ATOM   84   C CG1   . ILE A 1 12  ? -18.629 -4.607  32.901 1.00 19.94 ? 29  ILE C CG1   1 
ATOM   85   C CG2   . ILE A 1 12  ? -17.094 -6.115  31.581 1.00 20.75 ? 29  ILE C CG2   1 
ATOM   86   C CD1   . ILE A 1 12  ? -18.724 -3.607  31.783 1.00 22.66 ? 29  ILE C CD1   1 
ATOM   87   N N     . ARG A 1 13  ? -14.910 -6.692  34.020 1.00 20.25 ? 30  ARG C N     1 
ATOM   88   C CA    . ARG A 1 13  ? -13.592 -7.388  34.087 1.00 18.58 ? 30  ARG C CA    1 
ATOM   89   C C     . ARG A 1 13  ? -13.328 -7.943  35.493 1.00 22.64 ? 30  ARG C C     1 
ATOM   90   O O     . ARG A 1 13  ? -12.528 -8.869  35.618 1.00 23.39 ? 30  ARG C O     1 
ATOM   91   C CB    . ARG A 1 13  ? -12.471 -6.549  33.476 1.00 21.50 ? 30  ARG C CB    1 
ATOM   92   C CG    . ARG A 1 13  ? -12.579 -6.467  31.963 1.00 24.73 ? 30  ARG C CG    1 
ATOM   93   C CD    . ARG A 1 13  ? -11.468 -5.691  31.302 1.00 20.60 ? 30  ARG C CD    1 
ATOM   94   N NE    . ARG A 1 13  ? -11.730 -5.573  29.881 1.00 25.43 ? 30  ARG C NE    1 
ATOM   95   C CZ    . ARG A 1 13  ? -11.243 -4.610  29.118 0.81 25.68 ? 30  ARG C CZ    1 
ATOM   96   N NH1   . ARG A 1 13  ? -10.463 -3.687  29.645 1.00 24.32 ? 30  ARG C NH1   1 
ATOM   97   N NH2   . ARG A 1 13  ? -11.537 -4.569  27.833 0.80 31.35 ? 30  ARG C NH2   1 
ATOM   98   N N     . GLY A 1 14  ? -13.966 -7.362  36.516 1.00 20.30 ? 31  GLY C N     1 
ATOM   99   C CA    . GLY A 1 14  ? -13.926 -7.865  37.903 1.00 22.03 ? 31  GLY C CA    1 
ATOM   100  C C     . GLY A 1 14  ? -14.596 -9.232  37.993 1.00 22.71 ? 31  GLY C C     1 
ATOM   101  O O     . GLY A 1 14  ? -14.226 -10.013 38.868 1.00 31.22 ? 31  GLY C O     1 
ATOM   102  N N     . GLY A 1 15  ? -15.613 -9.454  37.155 1.00 24.34 ? 32  GLY C N     1 
ATOM   103  C CA    . GLY A 1 15  ? -16.383 -10.702 37.019 1.00 28.74 ? 32  GLY C CA    1 
ATOM   104  C C     . GLY A 1 15  ? -17.803 -10.400 36.577 1.00 29.67 ? 32  GLY C C     1 
ATOM   105  O O     . GLY A 1 15  ? -18.356 -9.401  37.040 1.00 26.33 ? 32  GLY C O     1 
ATOM   106  N N     . ARG A 1 16  ? -18.384 -11.282 35.759 1.00 29.63 ? 33  ARG C N     1 
ATOM   107  C CA    . ARG A 1 16  ? -19.755 -11.091 35.212 1.00 31.10 ? 33  ARG C CA    1 
ATOM   108  C C     . ARG A 1 16  ? -20.737 -12.010 35.939 1.00 32.03 ? 33  ARG C C     1 
ATOM   109  O O     . ARG A 1 16  ? -21.785 -12.307 35.377 1.00 29.85 ? 33  ARG C O     1 
ATOM   110  C CB    . ARG A 1 16  ? -19.815 -11.369 33.708 1.00 30.00 ? 33  ARG C CB    1 
ATOM   111  C CG    . ARG A 1 16  ? -18.816 -10.586 32.872 1.00 30.00 ? 33  ARG C CG    1 
ATOM   112  C CD    . ARG A 1 16  ? -19.237 -9.176  32.539 1.00 30.00 ? 33  ARG C CD    1 
ATOM   113  N NE    . ARG A 1 16  ? -20.634 -8.874  32.260 1.00 30.00 ? 33  ARG C NE    1 
ATOM   114  C CZ    . ARG A 1 16  ? -21.447 -8.256  33.112 1.00 30.00 ? 33  ARG C CZ    1 
ATOM   115  N NH1   . ARG A 1 16  ? -21.014 -7.933  34.315 1.00 30.00 ? 33  ARG C NH1   1 
ATOM   116  N NH2   . ARG A 1 16  ? -22.694 -7.983  32.775 1.00 30.00 ? 33  ARG C NH2   1 
ATOM   117  N N     . GLU A 1 17  ? -20.411 -12.409 37.166 1.00 30.87 ? 34  GLU C N     1 
ATOM   118  C CA    . GLU A 1 17  ? -21.281 -13.339 37.933 1.00 35.64 ? 34  GLU C CA    1 
ATOM   119  C C     . GLU A 1 17  ? -22.682 -12.752 38.150 1.00 32.97 ? 34  GLU C C     1 
ATOM   120  O O     . GLU A 1 17  ? -23.627 -13.537 38.148 1.00 32.60 ? 34  GLU C O     1 
ATOM   121  C CB    . GLU A 1 17  ? -20.654 -13.673 39.284 1.00 34.26 ? 34  GLU C CB    1 
ATOM   122  C CG    . GLU A 1 17  ? -19.385 -14.488 39.160 1.00 40.66 ? 34  GLU C CG    1 
ATOM   123  C CD    . GLU A 1 17  ? -18.128 -13.660 39.333 1.00 39.77 ? 34  GLU C CD    1 
ATOM   124  O OE1   . GLU A 1 17  ? -18.178 -12.483 38.998 1.00 36.17 ? 34  GLU C OE1   1 
ATOM   125  O OE2   . GLU A 1 17  ? -17.117 -14.201 39.810 1.00 40.03 ? 34  GLU C OE2   1 
ATOM   126  N N     . ASP A 1 18  ? -22.799 -11.438 38.364 1.00 27.66 ? 35  ASP C N     1 
ATOM   127  C CA    . ASP A 1 18  ? -24.108 -10.798 38.657 1.00 28.45 ? 35  ASP C CA    1 
ATOM   128  C C     . ASP A 1 18  ? -24.745 -10.186 37.404 1.00 26.86 ? 35  ASP C C     1 
ATOM   129  O O     . ASP A 1 18  ? -25.695 -9.425  37.564 1.00 27.53 ? 35  ASP C O     1 
ATOM   130  C CB    . ASP A 1 18  ? -23.966 -9.751  39.760 1.00 27.02 ? 35  ASP C CB    1 
ATOM   131  C CG    . ASP A 1 18  ? -23.658 -10.376 41.102 1.00 27.81 ? 35  ASP C CG    1 
ATOM   132  O OD1   . ASP A 1 18  ? -24.053 -11.530 41.296 1.00 31.25 ? 35  ASP C OD1   1 
ATOM   133  O OD2   . ASP A 1 18  ? -23.022 -9.709  41.926 1.00 26.16 ? 35  ASP C OD2   1 
ATOM   134  N N     . ARG A 1 19  ? -24.305 -10.585 36.210 1.00 30.89 ? 36  ARG C N     1 
ATOM   135  C CA    . ARG A 1 19  ? -24.794 -9.964  34.948 1.00 32.36 ? 36  ARG C CA    1 
ATOM   136  C C     . ARG A 1 19  ? -26.321 -10.047 34.853 1.00 31.27 ? 36  ARG C C     1 
ATOM   137  O O     . ARG A 1 19  ? -26.929 -9.053  34.444 1.00 28.81 ? 36  ARG C O     1 
ATOM   138  C CB    . ARG A 1 19  ? -24.198 -10.696 33.743 1.00 31.44 ? 36  ARG C CB    1 
ATOM   139  N N     . THR A 1 20  ? -26.922 -11.177 35.212 1.00 31.39 ? 37  THR C N     1 
ATOM   140  C CA    . THR A 1 20  ? -28.405 -11.242 35.150 1.00 33.40 ? 37  THR C CA    1 
ATOM   141  C C     . THR A 1 20  ? -29.005 -10.286 36.188 1.00 35.79 ? 37  THR C C     1 
ATOM   142  O O     . THR A 1 20  ? -30.008 -9.637  35.861 1.00 32.17 ? 37  THR C O     1 
ATOM   143  C CB    . THR A 1 20  ? -28.919 -12.674 35.308 1.00 39.10 ? 37  THR C CB    1 
ATOM   144  O OG1   . THR A 1 20  ? -28.122 -13.489 34.452 1.00 40.29 ? 37  THR C OG1   1 
ATOM   145  C CG2   . THR A 1 20  ? -30.375 -12.804 34.925 1.00 42.33 ? 37  THR C CG2   1 
ATOM   146  N N     . LEU A 1 21  ? -28.416 -10.190 37.386 1.00 31.70 ? 38  LEU C N     1 
ATOM   147  C CA    . LEU A 1 21  ? -29.011 -9.259  38.373 1.00 24.27 ? 38  LEU C CA    1 
ATOM   148  C C     . LEU A 1 21  ? -28.955 -7.827  37.825 1.00 28.97 ? 38  LEU C C     1 
ATOM   149  O O     . LEU A 1 21  ? -29.922 -7.085  38.006 1.00 25.89 ? 38  LEU C O     1 
ATOM   150  C CB    . LEU A 1 21  ? -28.246 -9.391  39.690 1.00 28.82 ? 38  LEU C CB    1 
ATOM   151  C CG    . LEU A 1 21  ? -28.658 -8.415  40.785 1.00 31.44 ? 38  LEU C CG    1 
ATOM   152  C CD1   . LEU A 1 21  ? -30.115 -8.613  41.165 1.00 31.00 ? 38  LEU C CD1   1 
ATOM   153  C CD2   . LEU A 1 21  ? -27.759 -8.565  41.997 1.00 27.32 ? 38  LEU C CD2   1 
ATOM   154  N N     . TYR A 1 22  ? -27.850 -7.465  37.174 1.00 25.79 ? 39  TYR C N     1 
ATOM   155  C CA    . TYR A 1 22  ? -27.680 -6.081  36.667 1.00 25.57 ? 39  TYR C CA    1 
ATOM   156  C C     . TYR A 1 22  ? -28.786 -5.720  35.677 1.00 25.58 ? 39  TYR C C     1 
ATOM   157  O O     . TYR A 1 22  ? -29.307 -4.617  35.765 1.00 24.62 ? 39  TYR C O     1 
ATOM   158  C CB    . TYR A 1 22  ? -26.324 -5.901  35.991 1.00 28.00 ? 39  TYR C CB    1 
ATOM   159  C CG    . TYR A 1 22  ? -25.128 -6.132  36.874 1.00 27.36 ? 39  TYR C CG    1 
ATOM   160  C CD1   . TYR A 1 22  ? -25.214 -6.123  38.256 1.00 24.06 ? 39  TYR C CD1   1 
ATOM   161  C CD2   . TYR A 1 22  ? -23.893 -6.362  36.308 1.00 26.65 ? 39  TYR C CD2   1 
ATOM   162  C CE1   . TYR A 1 22  ? -24.094 -6.340  39.043 1.00 21.35 ? 39  TYR C CE1   1 
ATOM   163  C CE2   . TYR A 1 22  ? -22.768 -6.589  37.075 1.00 24.70 ? 39  TYR C CE2   1 
ATOM   164  C CZ    . TYR A 1 22  ? -22.867 -6.577  38.450 1.00 23.31 ? 39  TYR C CZ    1 
ATOM   165  O OH    . TYR A 1 22  ? -21.738 -6.797  39.176 1.00 20.86 ? 39  TYR C OH    1 
ATOM   166  N N     . GLU A 1 23  ? -29.112 -6.618  34.749 1.00 27.84 ? 40  GLU C N     1 
ATOM   167  C CA    . GLU A 1 23  ? -30.152 -6.259  33.786 1.00 31.59 ? 40  GLU C CA    1 
ATOM   168  C C     . GLU A 1 23  ? -31.492 -6.049  34.485 1.00 30.51 ? 40  GLU C C     1 
ATOM   169  O O     . GLU A 1 23  ? -32.264 -5.163  34.095 1.00 29.80 ? 40  GLU C O     1 
ATOM   170  C CB    . GLU A 1 23  ? -30.231 -7.309  32.670 1.00 38.39 ? 40  GLU C CB    1 
ATOM   171  C CG    . GLU A 1 23  ? -30.581 -8.696  33.121 1.00 43.26 ? 40  GLU C CG    1 
ATOM   172  C CD    . GLU A 1 23  ? -30.637 -9.707  31.986 1.00 58.76 ? 40  GLU C CD    1 
ATOM   173  O OE1   . GLU A 1 23  ? -29.768 -9.641  31.087 1.00 67.84 ? 40  GLU C OE1   1 
ATOM   174  O OE2   . GLU A 1 23  ? -31.532 -10.585 32.008 1.00 66.10 ? 40  GLU C OE2   1 
ATOM   175  N N     . ARG A 1 24  ? -31.755 -6.803  35.554 1.00 31.06 ? 41  ARG C N     1 
ATOM   176  C CA    . ARG A 1 24  ? -32.961 -6.571  36.344 1.00 32.29 ? 41  ARG C CA    1 
ATOM   177  C C     . ARG A 1 24  ? -32.960 -5.183  36.967 1.00 29.87 ? 41  ARG C C     1 
ATOM   178  O O     . ARG A 1 24  ? -33.993 -4.500  36.981 1.00 29.73 ? 41  ARG C O     1 
ATOM   179  C CB    . ARG A 1 24  ? -33.086 -7.636  37.429 1.00 34.86 ? 41  ARG C CB    1 
ATOM   180  C CG    . ARG A 1 24  ? -34.022 -8.773  37.111 1.00 43.75 ? 41  ARG C CG    1 
ATOM   181  C CD    . ARG A 1 24  ? -33.897 -9.816  38.196 1.00 44.29 ? 41  ARG C CD    1 
ATOM   182  N NE    . ARG A 1 24  ? -34.607 -9.429  39.408 1.00 45.55 ? 41  ARG C NE    1 
ATOM   183  C CZ    . ARG A 1 24  ? -34.436 -10.017 40.585 1.00 44.05 ? 41  ARG C CZ    1 
ATOM   184  N NH1   . ARG A 1 24  ? -33.581 -11.019 40.741 1.00 43.52 ? 41  ARG C NH1   1 
ATOM   185  N NH2   . ARG A 1 24  ? -35.127 -9.578  41.636 1.00 41.67 ? 41  ARG C NH2   1 
ATOM   186  N N     . ILE A 1 25  ? -31.816 -4.763  37.516 1.00 28.89 ? 42  ILE C N     1 
ATOM   187  C CA    . ILE A 1 25  ? -31.701 -3.426  38.090 1.00 26.30 ? 42  ILE C CA    1 
ATOM   188  C C     . ILE A 1 25  ? -31.899 -2.366  37.018 1.00 26.74 ? 42  ILE C C     1 
ATOM   189  O O     . ILE A 1 25  ? -32.650 -1.400  37.203 1.00 28.12 ? 42  ILE C O     1 
ATOM   190  C CB    . ILE A 1 25  ? -30.341 -3.260  38.795 1.00 26.97 ? 42  ILE C CB    1 
ATOM   191  C CG1   . ILE A 1 25  ? -30.225 -4.220  39.982 1.00 24.25 ? 42  ILE C CG1   1 
ATOM   192  C CG2   . ILE A 1 25  ? -30.091 -1.802  39.176 1.00 27.15 ? 42  ILE C CG2   1 
ATOM   193  C CD1   . ILE A 1 25  ? -28.784 -4.382  40.504 1.00 26.06 ? 42  ILE C CD1   1 
ATOM   194  N N     . VAL A 1 26  ? -31.180 -2.501  35.897 1.00 28.40 ? 43  VAL C N     1 
ATOM   195  C CA    . VAL A 1 26  ? -31.282 -1.502  34.837 1.00 28.78 ? 43  VAL C CA    1 
ATOM   196  C C     . VAL A 1 26  ? -32.715 -1.386  34.350 1.00 28.10 ? 43  VAL C C     1 
ATOM   197  O O     . VAL A 1 26  ? -33.225 -0.276  34.151 1.00 26.88 ? 43  VAL C O     1 
ATOM   198  C CB    . VAL A 1 26  ? -30.320 -1.841  33.682 1.00 27.29 ? 43  VAL C CB    1 
ATOM   199  C CG1   . VAL A 1 26  ? -30.711 -1.086  32.422 1.00 29.46 ? 43  VAL C CG1   1 
ATOM   200  C CG2   . VAL A 1 26  ? -28.900 -1.472  34.077 1.00 25.70 ? 43  VAL C CG2   1 
ATOM   201  N N     . SER A 1 27  ? -33.399 -2.521  34.192 1.00 27.57 ? 44  SER C N     1 
ATOM   202  C CA    . SER A 1 27  ? -34.748 -2.452  33.640 1.00 31.33 ? 44  SER C CA    1 
ATOM   203  C C     . SER A 1 27  ? -35.697 -1.755  34.605 1.00 30.83 ? 44  SER C C     1 
ATOM   204  O O     . SER A 1 27  ? -36.551 -0.969  34.181 1.00 35.12 ? 44  SER C O     1 
ATOM   205  C CB    . SER A 1 27  ? -35.246 -3.845  33.259 1.00 32.44 ? 44  SER C CB    1 
ATOM   206  O OG    . SER A 1 27  ? -35.108 -4.759  34.324 1.00 42.45 ? 44  SER C OG    1 
ATOM   207  N N     . ARG A 1 28  ? -35.517 -1.968  35.909 1.00 31.42 ? 45  ARG C N     1 
ATOM   208  C CA    . ARG A 1 28  ? -36.292 -1.214  36.888 1.00 28.89 ? 45  ARG C CA    1 
ATOM   209  C C     . ARG A 1 28  ? -35.938 0.268   36.866 1.00 31.88 ? 45  ARG C C     1 
ATOM   210  O O     . ARG A 1 28  ? -36.823 1.128   36.967 1.00 31.82 ? 45  ARG C O     1 
ATOM   211  C CB    . ARG A 1 28  ? -36.063 -1.790  38.284 1.00 30.56 ? 45  ARG C CB    1 
ATOM   212  C CG    . ARG A 1 28  ? -37.130 -1.374  39.260 1.00 36.52 ? 45  ARG C CG    1 
ATOM   213  C CD    . ARG A 1 28  ? -38.481 -1.844  38.750 1.00 38.80 ? 45  ARG C CD    1 
ATOM   214  N NE    . ARG A 1 28  ? -39.439 -2.022  39.832 1.00 43.73 ? 45  ARG C NE    1 
ATOM   215  C CZ    . ARG A 1 28  ? -40.513 -2.792  39.760 1.00 41.68 ? 45  ARG C CZ    1 
ATOM   216  N NH1   . ARG A 1 28  ? -40.781 -3.508  38.677 1.00 41.90 ? 45  ARG C NH1   1 
ATOM   217  N NH2   . ARG A 1 28  ? -41.335 -2.851  40.803 1.00 45.91 ? 45  ARG C NH2   1 
ATOM   218  N N     . LEU A 1 29  ? -34.645 0.594   36.762 1.00 28.68 ? 46  LEU C N     1 
ATOM   219  C CA    . LEU A 1 29  ? -34.238 1.993   36.796 1.00 28.71 ? 46  LEU C CA    1 
ATOM   220  C C     . LEU A 1 29  ? -34.870 2.795   35.659 1.00 26.07 ? 46  LEU C C     1 
ATOM   221  O O     . LEU A 1 29  ? -35.114 4.001   35.808 1.00 28.74 ? 46  LEU C O     1 
ATOM   222  C CB    . LEU A 1 29  ? -32.708 2.083   36.739 1.00 28.49 ? 46  LEU C CB    1 
ATOM   223  C CG    . LEU A 1 29  ? -31.953 1.632   37.999 1.00 26.71 ? 46  LEU C CG    1 
ATOM   224  C CD1   . LEU A 1 29  ? -30.421 1.759   37.804 1.00 25.17 ? 46  LEU C CD1   1 
ATOM   225  C CD2   . LEU A 1 29  ? -32.385 2.437   39.198 1.00 26.98 ? 46  LEU C CD2   1 
ATOM   226  N N     . ARG A 1 30  ? -35.155 2.145   34.526 1.00 30.74 ? 47  ARG C N     1 
ATOM   227  C CA    . ARG A 1 30  ? -35.703 2.858   33.375 1.00 34.71 ? 47  ARG C CA    1 
ATOM   228  C C     . ARG A 1 30  ? -37.050 3.492   33.694 1.00 33.46 ? 47  ARG C C     1 
ATOM   229  O O     . ARG A 1 30  ? -37.432 4.488   33.064 1.00 34.18 ? 47  ARG C O     1 
ATOM   230  C CB    . ARG A 1 30  ? -35.848 1.903   32.198 1.00 35.26 ? 47  ARG C CB    1 
ATOM   231  C CG    . ARG A 1 30  ? -34.515 1.371   31.689 1.00 37.48 ? 47  ARG C CG    1 
ATOM   232  C CD    . ARG A 1 30  ? -34.506 1.063   30.211 1.00 36.54 ? 47  ARG C CD    1 
ATOM   233  N NE    . ARG A 1 30  ? -33.247 0.422   29.853 1.00 40.56 ? 47  ARG C NE    1 
ATOM   234  C CZ    . ARG A 1 30  ? -32.124 1.067   29.567 1.00 44.65 ? 47  ARG C CZ    1 
ATOM   235  N NH1   . ARG A 1 30  ? -32.069 2.391   29.561 1.00 40.96 ? 47  ARG C NH1   1 
ATOM   236  N NH2   . ARG A 1 30  ? -31.027 0.367   29.284 1.00 42.35 ? 47  ARG C NH2   1 
ATOM   237  N N     . ARG A 1 31  ? -37.763 2.945   34.677 1.00 33.26 ? 48  ARG C N     1 
ATOM   238  C CA    . ARG A 1 31  ? -39.037 3.505   35.104 1.00 31.71 ? 48  ARG C CA    1 
ATOM   239  C C     . ARG A 1 31  ? -38.898 4.902   35.688 1.00 36.87 ? 48  ARG C C     1 
ATOM   240  O O     . ARG A 1 31  ? -39.884 5.648   35.714 1.00 38.35 ? 48  ARG C O     1 
ATOM   241  C CB    . ARG A 1 31  ? -39.671 2.568   36.120 1.00 36.12 ? 48  ARG C CB    1 
ATOM   242  C CG    . ARG A 1 31  ? -39.833 1.144   35.609 1.00 35.96 ? 48  ARG C CG    1 
ATOM   243  C CD    . ARG A 1 31  ? -40.558 0.288   36.632 1.00 41.27 ? 48  ARG C CD    1 
ATOM   244  N NE    . ARG A 1 31  ? -40.893 -1.027  36.101 1.00 49.73 ? 48  ARG C NE    1 
ATOM   245  C CZ    . ARG A 1 31  ? -42.035 -1.658  36.340 1.00 53.11 ? 48  ARG C CZ    1 
ATOM   246  N NH1   . ARG A 1 31  ? -42.934 -1.164  37.177 1.00 50.43 ? 48  ARG C NH1   1 
ATOM   247  N NH2   . ARG A 1 31  ? -42.277 -2.816  35.728 1.00 54.72 ? 48  ARG C NH2   1 
ATOM   248  N N     . PHE A 1 32  ? -37.697 5.285   36.125 1.00 31.73 ? 49  PHE C N     1 
ATOM   249  C CA    . PHE A 1 32  ? -37.505 6.515   36.876 1.00 32.33 ? 49  PHE C CA    1 
ATOM   250  C C     . PHE A 1 32  ? -36.707 7.563   36.124 1.00 31.77 ? 49  PHE C C     1 
ATOM   251  O O     . PHE A 1 32  ? -36.645 8.714   36.572 1.00 30.87 ? 49  PHE C O     1 
ATOM   252  C CB    . PHE A 1 32  ? -36.835 6.181   38.220 1.00 34.03 ? 49  PHE C CB    1 
ATOM   253  C CG    . PHE A 1 32  ? -37.527 5.056   38.955 1.00 35.59 ? 49  PHE C CG    1 
ATOM   254  C CD1   . PHE A 1 32  ? -38.825 5.214   39.423 1.00 38.57 ? 49  PHE C CD1   1 
ATOM   255  C CD2   . PHE A 1 32  ? -36.917 3.822   39.108 1.00 36.11 ? 49  PHE C CD2   1 
ATOM   256  C CE1   . PHE A 1 32  ? -39.481 4.177   40.073 1.00 37.78 ? 49  PHE C CE1   1 
ATOM   257  C CE2   . PHE A 1 32  ? -37.575 2.777   39.756 1.00 35.41 ? 49  PHE C CE2   1 
ATOM   258  C CZ    . PHE A 1 32  ? -38.857 2.956   40.232 1.00 35.99 ? 49  PHE C CZ    1 
ATOM   259  N N     . GLY A 1 33  ? -36.125 7.209   34.988 1.00 34.78 ? 50  GLY C N     1 
ATOM   260  C CA    . GLY A 1 33  ? -35.419 8.175   34.174 1.00 31.68 ? 50  GLY C CA    1 
ATOM   261  C C     . GLY A 1 33  ? -34.647 7.460   33.085 1.00 27.04 ? 50  GLY C C     1 
ATOM   262  O O     . GLY A 1 33  ? -34.756 6.245   32.907 1.00 30.85 ? 50  GLY C O     1 
ATOM   263  N N     . THR A 1 34  ? -33.871 8.247   32.349 1.00 30.66 ? 51  THR C N     1 
ATOM   264  C CA    . THR A 1 34  ? -32.990 7.679   31.340 1.00 29.96 ? 51  THR C CA    1 
ATOM   265  C C     . THR A 1 34  ? -31.813 7.001   32.030 1.00 28.18 ? 51  THR C C     1 
ATOM   266  O O     . THR A 1 34  ? -31.103 7.632   32.818 1.00 26.22 ? 51  THR C O     1 
ATOM   267  C CB    . THR A 1 34  ? -32.468 8.761   30.390 1.00 34.35 ? 51  THR C CB    1 
ATOM   268  O OG1   . THR A 1 34  ? -33.523 9.665   30.022 1.00 35.38 ? 51  THR C OG1   1 
ATOM   269  C CG2   . THR A 1 34  ? -31.850 8.126   29.141 1.00 36.34 ? 51  THR C CG2   1 
ATOM   270  N N     . VAL A 1 35  ? -31.590 5.732   31.727 1.00 23.42 ? 52  VAL C N     1 
ATOM   271  C CA    . VAL A 1 35  ? -30.478 5.006   32.328 1.00 25.10 ? 52  VAL C CA    1 
ATOM   272  C C     . VAL A 1 35  ? -29.272 5.085   31.402 1.00 25.85 ? 52  VAL C C     1 
ATOM   273  O O     . VAL A 1 35  ? -29.333 4.651   30.241 1.00 26.38 ? 52  VAL C O     1 
ATOM   274  C CB    . VAL A 1 35  ? -30.840 3.549   32.634 1.00 27.30 ? 52  VAL C CB    1 
ATOM   275  C CG1   . VAL A 1 35  ? -29.604 2.817   33.161 1.00 24.80 ? 52  VAL C CG1   1 
ATOM   276  C CG2   . VAL A 1 35  ? -31.964 3.490   33.667 1.00 27.00 ? 52  VAL C CG2   1 
ATOM   277  N N     . LEU A 1 36  ? -28.182 5.638   31.933 1.00 25.42 ? 53  LEU C N     1 
ATOM   278  C CA    . LEU A 1 36  ? -26.883 5.696   31.267 1.00 23.34 ? 53  LEU C CA    1 
ATOM   279  C C     . LEU A 1 36  ? -26.057 4.553   31.833 1.00 27.90 ? 53  LEU C C     1 
ATOM   280  O O     . LEU A 1 36  ? -25.743 4.540   33.030 1.00 24.59 ? 53  LEU C O     1 
ATOM   281  C CB    . LEU A 1 36  ? -26.208 7.040   31.517 1.00 23.34 ? 53  LEU C CB    1 
ATOM   282  C CG    . LEU A 1 36  ? -27.009 8.291   31.154 1.00 24.95 ? 53  LEU C CG    1 
ATOM   283  C CD1   . LEU A 1 36  ? -26.284 9.583   31.528 1.00 23.16 ? 53  LEU C CD1   1 
ATOM   284  C CD2   . LEU A 1 36  ? -27.366 8.266   29.658 1.00 21.56 ? 53  LEU C CD2   1 
ATOM   285  N N     . THR A 1 37  ? -25.716 3.587   30.990 1.00 22.68 ? 54  THR C N     1 
ATOM   286  C CA    . THR A 1 37  ? -24.989 2.432   31.485 1.00 25.67 ? 54  THR C CA    1 
ATOM   287  C C     . THR A 1 37  ? -24.298 1.764   30.312 1.00 27.44 ? 54  THR C C     1 
ATOM   288  O O     . THR A 1 37  ? -24.698 1.926   29.156 1.00 27.96 ? 54  THR C O     1 
ATOM   289  C CB    . THR A 1 37  ? -25.919 1.445   32.213 1.00 28.55 ? 54  THR C CB    1 
ATOM   290  O OG1   . THR A 1 37  ? -25.142 0.546   33.012 1.00 27.87 ? 54  THR C OG1   1 
ATOM   291  C CG2   . THR A 1 37  ? -26.727 0.633   31.224 1.00 26.26 ? 54  THR C CG2   1 
ATOM   292  N N     . GLU A 1 38  ? -23.242 1.025   30.628 1.00 24.00 ? 55  GLU C N     1 
ATOM   293  C CA    . GLU A 1 38  ? -22.557 0.255   29.608 1.00 26.89 ? 55  GLU C CA    1 
ATOM   294  C C     . GLU A 1 38  ? -23.461 -0.845  29.065 1.00 30.69 ? 55  GLU C C     1 
ATOM   295  O O     . GLU A 1 38  ? -24.082 -1.592  29.829 1.00 30.03 ? 55  GLU C O     1 
ATOM   296  C CB    . GLU A 1 38  ? -21.282 -0.372  30.169 1.00 27.23 ? 55  GLU C CB    1 
ATOM   297  C CG    . GLU A 1 38  ? -20.583 -1.278  29.148 1.00 27.15 ? 55  GLU C CG    1 
ATOM   298  C CD    . GLU A 1 38  ? -19.847 -0.483  28.071 1.00 26.90 ? 55  GLU C CD    1 
ATOM   299  O OE1   . GLU A 1 38  ? -20.280 0.648   27.774 1.00 27.62 ? 55  GLU C OE1   1 
ATOM   300  O OE2   . GLU A 1 38  ? -18.827 -0.976  27.535 1.00 24.46 ? 55  GLU C OE2   1 
ATOM   301  N N     . HIS A 1 39  ? -23.436 -0.994  27.745 1.00 28.39 ? 56  HIS C N     1 
ATOM   302  C CA    . HIS A 1 39  ? -24.073 -2.177  27.119 1.00 38.06 ? 56  HIS C CA    1 
ATOM   303  C C     . HIS A 1 39  ? -22.918 -3.171  27.002 1.00 42.07 ? 56  HIS C C     1 
ATOM   304  O O     . HIS A 1 39  ? -21.948 -2.852  26.292 1.00 44.20 ? 56  HIS C O     1 
ATOM   305  C CB    . HIS A 1 39  ? -24.678 -1.864  25.754 1.00 38.11 ? 56  HIS C CB    1 
ATOM   306  C CG    . HIS A 1 39  ? -24.944 -3.092  24.952 1.00 51.34 ? 56  HIS C CG    1 
ATOM   307  N ND1   . HIS A 1 39  ? -23.978 -3.733  24.207 1.00 55.34 ? 56  HIS C ND1   1 
ATOM   308  C CD2   . HIS A 1 39  ? -26.063 -3.802  24.795 1.00 50.03 ? 56  HIS C CD2   1 
ATOM   309  C CE1   . HIS A 1 39  ? -24.511 -4.792  23.621 1.00 59.77 ? 56  HIS C CE1   1 
ATOM   310  N NE2   . HIS A 1 39  ? -25.777 -4.850  23.960 1.00 55.26 ? 56  HIS C NE2   1 
ATOM   311  N N     . VAL A 1 40  ? -22.986 -4.297  27.693 1.00 42.08 ? 57  VAL C N     1 
ATOM   312  C CA    . VAL A 1 40  ? -21.920 -5.289  27.740 1.00 46.11 ? 57  VAL C CA    1 
ATOM   313  C C     . VAL A 1 40  ? -22.309 -6.445  26.831 1.00 55.52 ? 57  VAL C C     1 
ATOM   314  O O     . VAL A 1 40  ? -23.457 -6.908  26.861 1.00 59.01 ? 57  VAL C O     1 
ATOM   315  C CB    . VAL A 1 40  ? -21.664 -5.770  29.180 1.00 42.10 ? 57  VAL C CB    1 
ATOM   316  N N     . ALA A 1 41  ? -21.363 -6.898  26.013 1.00 58.89 ? 58  ALA C N     1 
ATOM   317  C CA    . ALA A 1 41  ? -21.585 -8.061  25.161 1.00 60.46 ? 58  ALA C CA    1 
ATOM   318  C C     . ALA A 1 41  ? -21.701 -9.328  26.005 1.00 61.04 ? 58  ALA C C     1 
ATOM   319  O O     . ALA A 1 41  ? -20.974 -9.502  26.986 1.00 58.33 ? 58  ALA C O     1 
ATOM   320  C CB    . ALA A 1 41  ? -20.465 -8.198  24.147 1.00 53.04 ? 58  ALA C CB    1 
ATOM   321  N N     . GLY A 1 54  ? -6.914  -0.956  22.851 1.00 37.81 ? 71  GLY C N     1 
ATOM   322  C CA    . GLY A 1 54  ? -7.078  0.390   22.320 1.00 35.32 ? 71  GLY C CA    1 
ATOM   323  C C     . GLY A 1 54  ? -8.407  1.024   22.703 1.00 34.22 ? 71  GLY C C     1 
ATOM   324  O O     . GLY A 1 54  ? -8.523  2.253   22.765 1.00 32.39 ? 71  GLY C O     1 
ATOM   325  N N     . GLY A 1 55  ? -9.403  0.177   22.983 1.00 33.04 ? 72  GLY C N     1 
ATOM   326  C CA    . GLY A 1 55  ? -10.753 0.620   23.288 1.00 25.28 ? 72  GLY C CA    1 
ATOM   327  C C     . GLY A 1 55  ? -10.981 1.161   24.690 1.00 24.76 ? 72  GLY C C     1 
ATOM   328  O O     . GLY A 1 55  ? -12.037 1.752   24.944 1.00 22.81 ? 72  GLY C O     1 
ATOM   329  N N     . ASP A 1 56  ? -10.014 1.017   25.599 1.00 23.80 ? 73  ASP C N     1 
ATOM   330  C CA    . ASP A 1 56  ? -10.283 1.363   26.994 1.00 21.05 ? 73  ASP C CA    1 
ATOM   331  C C     . ASP A 1 56  ? -10.445 2.865   27.202 1.00 19.69 ? 73  ASP C C     1 
ATOM   332  O O     . ASP A 1 56  ? -11.235 3.290   28.056 1.00 19.73 ? 73  ASP C O     1 
ATOM   333  C CB    . ASP A 1 56  ? -9.182  0.809   27.907 1.00 23.70 ? 73  ASP C CB    1 
ATOM   334  C CG    . ASP A 1 56  ? -9.182  -0.721  27.988 1.00 28.14 ? 73  ASP C CG    1 
ATOM   335  O OD1   . ASP A 1 56  ? -10.166 -1.367  27.556 1.00 28.86 ? 73  ASP C OD1   1 
ATOM   336  O OD2   . ASP A 1 56  ? -8.198  -1.282  28.522 1.00 35.08 ? 73  ASP C OD2   1 
ATOM   337  N N     . ARG A 1 57  ? -9.677  3.682   26.482 1.00 18.15 ? 74  ARG C N     1 
ATOM   338  C CA    . ARG A 1 57  ? -9.770  5.125   26.685 1.00 19.83 ? 74  ARG C CA    1 
ATOM   339  C C     . ARG A 1 57  ? -11.177 5.628   26.401 1.00 20.43 ? 74  ARG C C     1 
ATOM   340  O O     . ARG A 1 57  ? -11.719 6.454   27.151 1.00 17.52 ? 74  ARG C O     1 
ATOM   341  C CB    . ARG A 1 57  ? -8.759  5.858   25.796 1.00 21.57 ? 74  ARG C CB    1 
ATOM   342  C CG    . ARG A 1 57  ? -8.618  7.342   26.138 1.00 25.28 ? 74  ARG C CG    1 
ATOM   343  C CD    . ARG A 1 57  ? -8.292  8.220   24.920 1.00 25.67 ? 74  ARG C CD    1 
ATOM   344  N NE    . ARG A 1 57  ? -9.421  8.302   23.998 1.00 26.64 ? 74  ARG C NE    1 
ATOM   345  C CZ    . ARG A 1 57  ? -10.491 9.063   24.188 1.00 27.68 ? 74  ARG C CZ    1 
ATOM   346  N NH1   . ARG A 1 57  ? -10.568 9.905   25.208 1.00 23.52 ? 74  ARG C NH1   1 
ATOM   347  N NH2   . ARG A 1 57  ? -11.501 8.988   23.324 1.00 25.47 ? 74  ARG C NH2   1 
ATOM   348  N N     . LEU A 1 58  ? -11.781 5.155   25.309 1.00 17.77 ? 75  LEU C N     1 
ATOM   349  C CA    . LEU A 1 58  ? -13.142 5.573   24.995 1.00 19.57 ? 75  LEU C CA    1 
ATOM   350  C C     . LEU A 1 58  ? -14.129 5.076   26.044 1.00 20.45 ? 75  LEU C C     1 
ATOM   351  O O     . LEU A 1 58  ? -15.043 5.809   26.435 1.00 20.49 ? 75  LEU C O     1 
ATOM   352  C CB    . LEU A 1 58  ? -13.532 5.073   23.608 1.00 21.51 ? 75  LEU C CB    1 
ATOM   353  C CG    . LEU A 1 58  ? -14.911 5.549   23.181 1.00 21.00 ? 75  LEU C CG    1 
ATOM   354  C CD1   . LEU A 1 58  ? -14.979 7.095   23.187 1.00 22.18 ? 75  LEU C CD1   1 
ATOM   355  C CD2   . LEU A 1 58  ? -15.255 4.971   21.813 1.00 23.64 ? 75  LEU C CD2   1 
ATOM   356  N N     . ILE A 1 59  ? -13.951 3.843   26.527 1.00 16.75 ? 76  ILE C N     1 
ATOM   357  C CA    . ILE A 1 59  ? -14.814 3.341   27.591 1.00 17.03 ? 76  ILE C CA    1 
ATOM   358  C C     . ILE A 1 59  ? -14.706 4.227   28.828 1.00 16.46 ? 76  ILE C C     1 
ATOM   359  O O     . ILE A 1 59  ? -15.717 4.593   29.441 1.00 17.11 ? 76  ILE C O     1 
ATOM   360  C CB    . ILE A 1 59  ? -14.474 1.876   27.910 1.00 17.92 ? 76  ILE C CB    1 
ATOM   361  C CG1   . ILE A 1 59  ? -14.880 1.004   26.713 1.00 21.87 ? 76  ILE C CG1   1 
ATOM   362  C CG2   . ILE A 1 59  ? -15.181 1.453   29.196 1.00 18.66 ? 76  ILE C CG2   1 
ATOM   363  C CD1   . ILE A 1 59  ? -14.285 -0.399  26.715 1.00 22.06 ? 76  ILE C CD1   1 
ATOM   364  N N     . HIS A 1 60  ? -13.475 4.589   29.206 1.00 15.96 ? 77  HIS C N     1 
ATOM   365  C CA    . HIS A 1 60  ? -13.273 5.487   30.341 1.00 17.50 ? 77  HIS C CA    1 
ATOM   366  C C     . HIS A 1 60  ? -13.977 6.822   30.109 1.00 20.12 ? 77  HIS C C     1 
ATOM   367  O O     . HIS A 1 60  ? -14.655 7.357   30.996 1.00 19.04 ? 77  HIS C O     1 
ATOM   368  C CB    . HIS A 1 60  ? -11.776 5.704   30.558 1.00 19.90 ? 77  HIS C CB    1 
ATOM   369  C CG    . HIS A 1 60  ? -11.457 6.663   31.658 1.00 19.71 ? 77  HIS C CG    1 
ATOM   370  N ND1   . HIS A 1 60  ? -11.244 8.006   31.430 1.00 22.56 ? 77  HIS C ND1   1 
ATOM   371  C CD2   . HIS A 1 60  ? -11.312 6.479   32.994 1.00 17.71 ? 77  HIS C CD2   1 
ATOM   372  C CE1   . HIS A 1 60  ? -11.002 8.613   32.580 1.00 22.61 ? 77  HIS C CE1   1 
ATOM   373  N NE2   . HIS A 1 60  ? -11.028 7.709   33.544 1.00 19.97 ? 77  HIS C NE2   1 
ATOM   374  N N     . GLU A 1 61  ? -13.794 7.393   28.919 1.00 17.39 ? 78  GLU C N     1 
ATOM   375  C CA    . GLU A 1 61  ? -14.393 8.682   28.606 1.00 18.76 ? 78  GLU C CA    1 
ATOM   376  C C     . GLU A 1 61  ? -15.916 8.640   28.707 1.00 18.56 ? 78  GLU C C     1 
ATOM   377  O O     . GLU A 1 61  ? -16.546 9.543   29.275 1.00 18.36 ? 78  GLU C O     1 
ATOM   378  C CB    . GLU A 1 61  ? -13.985 9.096   27.201 1.00 19.45 ? 78  GLU C CB    1 
ATOM   379  C CG    . GLU A 1 61  ? -14.791 10.288  26.724 1.00 22.54 ? 78  GLU C CG    1 
ATOM   380  C CD    . GLU A 1 61  ? -14.417 10.670  25.310 1.00 26.18 ? 78  GLU C CD    1 
ATOM   381  O OE1   . GLU A 1 61  ? -13.241 11.023  25.090 1.00 29.42 ? 78  GLU C OE1   1 
ATOM   382  O OE2   . GLU A 1 61  ? -15.294 10.565  24.421 1.00 26.29 ? 78  GLU C OE2   1 
ATOM   383  N N     . GLN A 1 62  ? -16.530 7.604   28.139 1.00 19.09 ? 79  GLN C N     1 
ATOM   384  C CA    . GLN A 1 62  ? -17.982 7.570   28.076 1.00 19.55 ? 79  GLN C CA    1 
ATOM   385  C C     . GLN A 1 62  ? -18.588 7.372   29.456 1.00 18.21 ? 79  GLN C C     1 
ATOM   386  O O     . GLN A 1 62  ? -19.566 8.039   29.812 1.00 18.46 ? 79  GLN C O     1 
ATOM   387  C CB    . GLN A 1 62  ? -18.423 6.479   27.103 1.00 19.57 ? 79  GLN C CB    1 
ATOM   388  C CG    . GLN A 1 62  ? -17.955 6.795   25.675 1.00 20.47 ? 79  GLN C CG    1 
ATOM   389  C CD    . GLN A 1 62  ? -18.634 5.960   24.614 1.00 25.65 ? 79  GLN C CD    1 
ATOM   390  O OE1   . GLN A 1 62  ? -18.930 4.785   24.825 1.00 26.64 ? 79  GLN C OE1   1 
ATOM   391  N NE2   . GLN A 1 62  ? -18.892 6.568   23.465 1.00 19.05 ? 79  GLN C NE2   1 
ATOM   392  N N     . ASN A 1 63  ? -18.002 6.488   30.264 1.00 18.56 ? 80  ASN C N     1 
ATOM   393  C CA    . ASN A 1 63  ? -18.524 6.316   31.613 1.00 20.82 ? 80  ASN C CA    1 
ATOM   394  C C     . ASN A 1 63  ? -18.304 7.562   32.455 1.00 20.76 ? 80  ASN C C     1 
ATOM   395  O O     . ASN A 1 63  ? -19.142 7.907   33.298 1.00 19.42 ? 80  ASN C O     1 
ATOM   396  C CB    . ASN A 1 63  ? -17.888 5.108   32.280 1.00 20.49 ? 80  ASN C CB    1 
ATOM   397  C CG    . ASN A 1 63  ? -18.537 3.817   31.860 1.00 21.09 ? 80  ASN C CG    1 
ATOM   398  O OD1   . ASN A 1 63  ? -19.529 3.391   32.467 1.00 25.35 ? 80  ASN C OD1   1 
ATOM   399  N ND2   . ASN A 1 63  ? -17.971 3.162   30.846 1.00 21.19 ? 80  ASN C ND2   1 
ATOM   400  N N     . LEU A 1 64  ? -17.178 8.241   32.262 1.00 19.78 ? 81  LEU C N     1 
ATOM   401  C CA    . LEU A 1 64  ? -16.948 9.450   33.045 1.00 22.34 ? 81  LEU C CA    1 
ATOM   402  C C     . LEU A 1 64  ? -17.965 10.526  32.683 1.00 25.01 ? 81  LEU C C     1 
ATOM   403  O O     . LEU A 1 64  ? -18.492 11.218  33.566 1.00 22.73 ? 81  LEU C O     1 
ATOM   404  C CB    . LEU A 1 64  ? -15.518 9.941   32.837 1.00 23.45 ? 81  LEU C CB    1 
ATOM   405  C CG    . LEU A 1 64  ? -15.020 11.087  33.710 1.00 31.26 ? 81  LEU C CG    1 
ATOM   406  C CD1   . LEU A 1 64  ? -15.091 10.717  35.186 1.00 24.81 ? 81  LEU C CD1   1 
ATOM   407  C CD2   . LEU A 1 64  ? -13.585 11.485  33.297 1.00 30.11 ? 81  LEU C CD2   1 
ATOM   408  N N     . GLU A 1 65  ? -18.277 10.671  31.393 1.00 19.46 ? 82  GLU C N     1 
ATOM   409  C CA    . GLU A 1 65  ? -19.281 11.663  31.003 1.00 24.90 ? 82  GLU C CA    1 
ATOM   410  C C     . GLU A 1 65  ? -20.663 11.291  31.521 1.00 24.41 ? 82  GLU C C     1 
ATOM   411  O O     . GLU A 1 65  ? -21.404 12.159  32.007 1.00 26.52 ? 82  GLU C O     1 
ATOM   412  C CB    . GLU A 1 65  ? -19.316 11.828  29.481 1.00 22.48 ? 82  GLU C CB    1 
ATOM   413  C CG    . GLU A 1 65  ? -20.222 12.971  29.001 1.00 32.14 ? 82  GLU C CG    1 
ATOM   414  C CD    . GLU A 1 65  ? -20.014 14.275  29.777 1.00 44.15 ? 82  GLU C CD    1 
ATOM   415  O OE1   . GLU A 1 65  ? -18.848 14.731  29.873 1.00 44.71 ? 82  GLU C OE1   1 
ATOM   416  O OE2   . GLU A 1 65  ? -21.003 14.826  30.322 1.00 44.28 ? 82  GLU C OE2   1 
ATOM   417  N N     . TRP A 1 66  ? -21.026 10.023  31.421 1.00 22.23 ? 83  TRP C N     1 
ATOM   418  C CA    . TRP A 1 66  ? -22.337 9.571   31.940 1.00 20.99 ? 83  TRP C CA    1 
ATOM   419  C C     . TRP A 1 66  ? -22.454 9.845   33.439 1.00 25.56 ? 83  TRP C C     1 
ATOM   420  O O     . TRP A 1 66  ? -23.476 10.356  33.884 1.00 25.49 ? 83  TRP C O     1 
ATOM   421  C CB    . TRP A 1 66  ? -22.496 8.080   31.670 1.00 21.08 ? 83  TRP C CB    1 
ATOM   422  C CG    . TRP A 1 66  ? -22.748 7.751   30.227 1.00 23.43 ? 83  TRP C CG    1 
ATOM   423  C CD1   . TRP A 1 66  ? -23.306 8.551   29.276 1.00 22.79 ? 83  TRP C CD1   1 
ATOM   424  C CD2   . TRP A 1 66  ? -22.439 6.503   29.578 1.00 21.22 ? 83  TRP C CD2   1 
ATOM   425  N NE1   . TRP A 1 66  ? -23.364 7.891   28.080 1.00 19.25 ? 83  TRP C NE1   1 
ATOM   426  C CE2   . TRP A 1 66  ? -22.841 6.635   28.234 1.00 21.82 ? 83  TRP C CE2   1 
ATOM   427  C CE3   . TRP A 1 66  ? -21.870 5.301   30.003 1.00 21.28 ? 83  TRP C CE3   1 
ATOM   428  C CZ2   . TRP A 1 66  ? -22.687 5.602   27.315 1.00 26.33 ? 83  TRP C CZ2   1 
ATOM   429  C CZ3   . TRP A 1 66  ? -21.716 4.284   29.091 1.00 23.79 ? 83  TRP C CZ3   1 
ATOM   430  C CH2   . TRP A 1 66  ? -22.122 4.434   27.769 1.00 24.49 ? 83  TRP C CH2   1 
ATOM   431  N N     . LEU A 1 67  ? -21.418 9.477   34.181 1.00 21.48 ? 84  LEU C N     1 
ATOM   432  C CA    . LEU A 1 67  ? -21.423 9.680   35.645 1.00 27.42 ? 84  LEU C CA    1 
ATOM   433  C C     . LEU A 1 67  ? -21.588 11.171  35.949 1.00 29.45 ? 84  LEU C C     1 
ATOM   434  O O     . LEU A 1 67  ? -22.363 11.497  36.843 1.00 30.72 ? 84  LEU C O     1 
ATOM   435  C CB    . LEU A 1 67  ? -20.102 9.129   36.177 1.00 30.11 ? 84  LEU C CB    1 
ATOM   436  C CG    . LEU A 1 67  ? -19.786 9.376   37.648 1.00 31.96 ? 84  LEU C CG    1 
ATOM   437  C CD1   . LEU A 1 67  ? -19.760 8.015   38.305 1.00 37.52 ? 84  LEU C CD1   1 
ATOM   438  C CD2   . LEU A 1 67  ? -18.431 10.029  37.722 1.00 28.33 ? 84  LEU C CD2   1 
ATOM   439  N N     . GLN A 1 68  ? -20.877 12.018  35.219 1.00 26.85 ? 85  GLN C N     1 
ATOM   440  C CA    . GLN A 1 68  ? -20.898 13.478  35.491 1.00 30.94 ? 85  GLN C CA    1 
ATOM   441  C C     . GLN A 1 68  ? -22.277 14.090  35.241 1.00 31.94 ? 85  GLN C C     1 
ATOM   442  O O     . GLN A 1 68  ? -22.613 15.067  35.906 1.00 37.59 ? 85  GLN C O     1 
ATOM   443  C CB    . GLN A 1 68  ? -19.913 14.214  34.595 1.00 31.55 ? 85  GLN C CB    1 
ATOM   444  C CG    . GLN A 1 68  ? -18.455 13.991  34.959 1.00 35.29 ? 85  GLN C CG    1 
ATOM   445  C CD    . GLN A 1 68  ? -17.512 14.810  34.110 1.00 38.25 ? 85  GLN C CD    1 
ATOM   446  O OE1   . GLN A 1 68  ? -16.893 14.307  33.168 1.00 40.35 ? 85  GLN C OE1   1 
ATOM   447  N NE2   . GLN A 1 68  ? -17.409 16.089  34.436 1.00 33.67 ? 85  GLN C NE2   1 
ATOM   448  N N     . GLN A 1 69  ? -23.022 13.555  34.295 1.00 29.14 ? 86  GLN C N     1 
ATOM   449  C CA    . GLN A 1 69  ? -24.313 14.194  33.956 1.00 36.31 ? 86  GLN C CA    1 
ATOM   450  C C     . GLN A 1 69  ? -25.471 13.449  34.620 1.00 32.42 ? 86  GLN C C     1 
ATOM   451  O O     . GLN A 1 69  ? -26.616 13.892  34.503 1.00 32.49 ? 86  GLN C O     1 
ATOM   452  C CB    . GLN A 1 69  ? -24.449 14.241  32.441 1.00 39.07 ? 86  GLN C CB    1 
ATOM   453  C CG    . GLN A 1 69  ? -24.480 12.893  31.739 1.00 37.56 ? 86  GLN C CG    1 
ATOM   454  C CD    . GLN A 1 69  ? -24.364 13.054  30.241 1.00 39.32 ? 86  GLN C CD    1 
ATOM   455  O OE1   . GLN A 1 69  ? -24.828 14.047  29.672 1.00 41.33 ? 86  GLN C OE1   1 
ATOM   456  N NE2   . GLN A 1 69  ? -23.725 12.094  29.592 1.00 30.24 ? 86  GLN C NE2   1 
ATOM   457  N N     . ALA A 1 70  ? -25.170 12.342  35.277 1.00 29.33 ? 87  ALA C N     1 
ATOM   458  C CA    . ALA A 1 70  ? -26.234 11.620  35.946 1.00 26.89 ? 87  ALA C CA    1 
ATOM   459  C C     . ALA A 1 70  ? -26.737 12.420  37.140 1.00 27.89 ? 87  ALA C C     1 
ATOM   460  O O     . ALA A 1 70  ? -26.018 13.221  37.740 1.00 29.43 ? 87  ALA C O     1 
ATOM   461  C CB    . ALA A 1 70  ? -25.757 10.253  36.402 1.00 24.48 ? 87  ALA C CB    1 
ATOM   462  N N     . ASP A 1 71  ? -27.999 12.222  37.456 1.00 27.99 ? 88  ASP C N     1 
ATOM   463  C CA    . ASP A 1 71  ? -28.543 12.849  38.645 1.00 26.33 ? 88  ASP C CA    1 
ATOM   464  C C     . ASP A 1 71  ? -28.445 11.931  39.850 1.00 26.03 ? 88  ASP C C     1 
ATOM   465  O O     . ASP A 1 71  ? -28.401 12.422  40.978 1.00 28.28 ? 88  ASP C O     1 
ATOM   466  C CB    . ASP A 1 71  ? -29.981 13.290  38.376 1.00 28.84 ? 88  ASP C CB    1 
ATOM   467  C CG    . ASP A 1 71  ? -30.066 14.256  37.185 1.00 33.70 ? 88  ASP C CG    1 
ATOM   468  O OD1   . ASP A 1 71  ? -29.506 15.379  37.285 1.00 34.46 ? 88  ASP C OD1   1 
ATOM   469  O OD2   . ASP A 1 71  ? -30.700 13.905  36.162 1.00 36.68 ? 88  ASP C OD2   1 
ATOM   470  N N     . VAL A 1 72  ? -28.380 10.613  39.629 1.00 24.79 ? 89  VAL C N     1 
ATOM   471  C CA    . VAL A 1 72  ? -28.109 9.629   40.674 1.00 25.11 ? 89  VAL C CA    1 
ATOM   472  C C     . VAL A 1 72  ? -27.158 8.596   40.090 1.00 23.12 ? 89  VAL C C     1 
ATOM   473  O O     . VAL A 1 72  ? -27.246 8.263   38.903 1.00 25.13 ? 89  VAL C O     1 
ATOM   474  C CB    . VAL A 1 72  ? -29.399 8.953   41.188 1.00 31.18 ? 89  VAL C CB    1 
ATOM   475  C CG1   . VAL A 1 72  ? -29.073 7.770   42.101 1.00 26.69 ? 89  VAL C CG1   1 
ATOM   476  C CG2   . VAL A 1 72  ? -30.284 9.966   41.907 1.00 35.17 ? 89  VAL C CG2   1 
ATOM   477  N N     . VAL A 1 73  ? -26.219 8.125   40.905 1.00 18.37 ? 90  VAL C N     1 
ATOM   478  C CA    . VAL A 1 73  ? -25.309 7.054   40.516 1.00 18.21 ? 90  VAL C CA    1 
ATOM   479  C C     . VAL A 1 73  ? -25.717 5.827   41.306 1.00 22.16 ? 90  VAL C C     1 
ATOM   480  O O     . VAL A 1 73  ? -25.781 5.875   42.544 1.00 21.38 ? 90  VAL C O     1 
ATOM   481  C CB    . VAL A 1 73  ? -23.839 7.406   40.786 1.00 20.81 ? 90  VAL C CB    1 
ATOM   482  C CG1   . VAL A 1 73  ? -22.946 6.133   40.640 1.00 19.55 ? 90  VAL C CG1   1 
ATOM   483  C CG2   . VAL A 1 73  ? -23.373 8.551   39.881 1.00 20.93 ? 90  VAL C CG2   1 
ATOM   484  N N     . VAL A 1 74  ? -26.021 4.741   40.598 1.00 17.43 ? 91  VAL C N     1 
ATOM   485  C CA    . VAL A 1 74  ? -26.402 3.474   41.215 1.00 17.86 ? 91  VAL C CA    1 
ATOM   486  C C     . VAL A 1 74  ? -25.323 2.442   40.910 1.00 21.01 ? 91  VAL C C     1 
ATOM   487  O O     . VAL A 1 74  ? -25.000 2.201   39.742 1.00 22.77 ? 91  VAL C O     1 
ATOM   488  C CB    . VAL A 1 74  ? -27.774 2.999   40.713 1.00 17.19 ? 91  VAL C CB    1 
ATOM   489  C CG1   . VAL A 1 74  ? -28.177 1.674   41.417 1.00 21.72 ? 91  VAL C CG1   1 
ATOM   490  C CG2   . VAL A 1 74  ? -28.813 4.074   40.928 1.00 20.20 ? 91  VAL C CG2   1 
ATOM   491  N N     . ALA A 1 75  ? -24.759 1.831   41.954 1.00 17.58 ? 92  ALA C N     1 
ATOM   492  C CA    . ALA A 1 75  ? -23.667 0.877   41.790 1.00 18.31 ? 92  ALA C CA    1 
ATOM   493  C C     . ALA A 1 75  ? -24.024 -0.409  42.501 1.00 16.59 ? 92  ALA C C     1 
ATOM   494  O O     . ALA A 1 75  ? -24.427 -0.374  43.668 1.00 22.06 ? 92  ALA C O     1 
ATOM   495  C CB    . ALA A 1 75  ? -22.352 1.420   42.358 1.00 20.36 ? 92  ALA C CB    1 
ATOM   496  N N     . GLU A 1 76  ? -23.849 -1.532  41.823 1.00 18.79 ? 93  GLU C N     1 
ATOM   497  C CA    . GLU A 1 76  ? -23.978 -2.820  42.482 1.00 16.69 ? 93  GLU C CA    1 
ATOM   498  C C     . GLU A 1 76  ? -22.560 -3.216  42.872 1.00 17.80 ? 93  GLU C C     1 
ATOM   499  O O     . GLU A 1 76  ? -21.699 -3.406  42.002 1.00 18.72 ? 93  GLU C O     1 
ATOM   500  C CB    . GLU A 1 76  ? -24.659 -3.837  41.570 1.00 19.24 ? 93  GLU C CB    1 
ATOM   501  C CG    . GLU A 1 76  ? -25.580 -4.828  42.297 1.00 22.42 ? 93  GLU C CG    1 
ATOM   502  C CD    . GLU A 1 76  ? -24.839 -5.765  43.260 1.00 21.94 ? 93  GLU C CD    1 
ATOM   503  O OE1   . GLU A 1 76  ? -23.597 -5.835  43.183 1.00 22.44 ? 93  GLU C OE1   1 
ATOM   504  O OE2   . GLU A 1 76  ? -25.507 -6.430  44.098 1.00 25.95 ? 93  GLU C OE2   1 
ATOM   505  N N     . VAL A 1 77  ? -22.287 -3.262  44.173 1.00 17.29 ? 94  VAL C N     1 
ATOM   506  C CA    . VAL A 1 77  ? -20.907 -3.372  44.643 1.00 17.83 ? 94  VAL C CA    1 
ATOM   507  C C     . VAL A 1 77  ? -20.609 -4.745  45.248 1.00 16.81 ? 94  VAL C C     1 
ATOM   508  O O     . VAL A 1 77  ? -19.645 -4.888  45.993 1.00 17.85 ? 94  VAL C O     1 
ATOM   509  C CB    . VAL A 1 77  ? -20.572 -2.261  45.648 1.00 15.40 ? 94  VAL C CB    1 
ATOM   510  C CG1   . VAL A 1 77  ? -20.477 -0.915  44.944 1.00 17.70 ? 94  VAL C CG1   1 
ATOM   511  C CG2   . VAL A 1 77  ? -21.600 -2.270  46.815 1.00 18.06 ? 94  VAL C CG2   1 
ATOM   512  N N     . THR A 1 78  ? -21.416 -5.761  44.948 1.00 17.89 ? 95  THR C N     1 
ATOM   513  C CA    . THR A 1 78  ? -21.181 -7.078  45.536 1.00 16.88 ? 95  THR C CA    1 
ATOM   514  C C     . THR A 1 78  ? -19.926 -7.736  44.966 1.00 19.15 ? 95  THR C C     1 
ATOM   515  O O     . THR A 1 78  ? -19.103 -8.270  45.712 1.00 18.67 ? 95  THR C O     1 
ATOM   516  C CB    . THR A 1 78  ? -22.423 -7.959  45.342 1.00 16.41 ? 95  THR C CB    1 
ATOM   517  O OG1   . THR A 1 78  ? -23.552 -7.303  45.947 1.00 17.95 ? 95  THR C OG1   1 
ATOM   518  C CG2   . THR A 1 78  ? -22.233 -9.322  45.965 1.00 20.97 ? 95  THR C CG2   1 
ATOM   519  N N     . GLN A 1 79  ? -19.752 -7.696  43.649 1.00 19.82 ? 96  GLN C N     1 
ATOM   520  C CA    . GLN A 1 79  ? -18.561 -8.264  43.031 1.00 17.74 ? 96  GLN C CA    1 
ATOM   521  C C     . GLN A 1 79  ? -17.429 -7.238  43.058 1.00 18.69 ? 96  GLN C C     1 
ATOM   522  O O     . GLN A 1 79  ? -17.615 -6.114  42.572 1.00 18.36 ? 96  GLN C O     1 
ATOM   523  C CB    . GLN A 1 79  ? -18.866 -8.676  41.598 1.00 23.06 ? 96  GLN C CB    1 
ATOM   524  C CG    . GLN A 1 79  ? -17.732 -9.433  40.941 1.00 23.87 ? 96  GLN C CG    1 
ATOM   525  C CD    . GLN A 1 79  ? -17.596 -10.835 41.481 1.00 31.76 ? 96  GLN C CD    1 
ATOM   526  O OE1   . GLN A 1 79  ? -18.589 -11.447 41.886 1.00 30.58 ? 96  GLN C OE1   1 
ATOM   527  N NE2   . GLN A 1 79  ? -16.371 -11.355 41.496 1.00 32.34 ? 96  GLN C NE2   1 
ATOM   528  N N     . PRO A 1 80  ? -16.268 -7.555  43.626 1.00 19.95 ? 97  PRO C N     1 
ATOM   529  C CA    . PRO A 1 80  ? -15.180 -6.564  43.644 1.00 16.07 ? 97  PRO C CA    1 
ATOM   530  C C     . PRO A 1 80  ? -14.730 -6.215  42.226 1.00 14.41 ? 97  PRO C C     1 
ATOM   531  O O     . PRO A 1 80  ? -14.583 -7.083  41.366 1.00 17.31 ? 97  PRO C O     1 
ATOM   532  C CB    . PRO A 1 80  ? -14.072 -7.267  44.441 1.00 19.31 ? 97  PRO C CB    1 
ATOM   533  C CG    . PRO A 1 80  ? -14.838 -8.286  45.311 1.00 21.88 ? 97  PRO C CG    1 
ATOM   534  C CD    . PRO A 1 80  ? -15.897 -8.783  44.341 1.00 21.52 ? 97  PRO C CD    1 
ATOM   535  N N     . SER A 1 81  ? -14.519 -4.921  41.991 1.00 16.80 ? 98  SER C N     1 
ATOM   536  C CA    . SER A 1 81  ? -14.273 -4.445  40.637 1.00 14.88 ? 98  SER C CA    1 
ATOM   537  C C     . SER A 1 81  ? -13.492 -3.144  40.721 1.00 14.29 ? 98  SER C C     1 
ATOM   538  O O     . SER A 1 81  ? -13.919 -2.216  41.416 1.00 15.49 ? 98  SER C O     1 
ATOM   539  C CB    . SER A 1 81  ? -15.601 -4.243  39.888 1.00 18.28 ? 98  SER C CB    1 
ATOM   540  O OG    . SER A 1 81  ? -15.492 -3.278  38.845 1.00 16.99 ? 98  SER C OG    1 
ATOM   541  N N     . LEU A 1 82  ? -12.353 -3.072  40.019 1.00 12.86 ? 99  LEU C N     1 
ATOM   542  C CA    . LEU A 1 82  ? -11.626 -1.802  39.980 1.00 15.32 ? 99  LEU C CA    1 
ATOM   543  C C     . LEU A 1 82  ? -12.469 -0.723  39.337 1.00 14.93 ? 99  LEU C C     1 
ATOM   544  O O     . LEU A 1 82  ? -12.495 0.423   39.805 1.00 14.89 ? 99  LEU C O     1 
ATOM   545  C CB    . LEU A 1 82  ? -10.308 -1.930  39.196 1.00 13.25 ? 99  LEU C CB    1 
ATOM   546  C CG    . LEU A 1 82  ? -9.282  -2.858  39.835 1.00 17.61 ? 99  LEU C CG    1 
ATOM   547  C CD1   . LEU A 1 82  ? -8.276  -3.343  38.790 1.00 16.18 ? 99  LEU C CD1   1 
ATOM   548  C CD2   . LEU A 1 82  ? -8.614  -2.138  41.029 1.00 17.84 ? 99  LEU C CD2   1 
ATOM   549  N N     . GLY A 1 83  ? -13.117 -1.058  38.221 1.00 15.07 ? 100 GLY C N     1 
ATOM   550  C CA    . GLY A 1 83  ? -13.853 -0.053  37.480 1.00 15.43 ? 100 GLY C CA    1 
ATOM   551  C C     . GLY A 1 83  ? -15.011 0.509   38.274 1.00 15.45 ? 100 GLY C C     1 
ATOM   552  O O     . GLY A 1 83  ? -15.273 1.710   38.243 1.00 15.61 ? 100 GLY C O     1 
ATOM   553  N N     . VAL A 1 84  ? -15.731 -0.349  38.997 1.00 12.86 ? 101 VAL C N     1 
ATOM   554  C CA    . VAL A 1 84  ? -16.845 0.173   39.774 1.00 14.52 ? 101 VAL C CA    1 
ATOM   555  C C     . VAL A 1 84  ? -16.323 1.058   40.894 1.00 15.31 ? 101 VAL C C     1 
ATOM   556  O O     . VAL A 1 84  ? -16.870 2.135   41.162 1.00 15.08 ? 101 VAL C O     1 
ATOM   557  C CB    . VAL A 1 84  ? -17.710 -0.977  40.322 1.00 14.26 ? 101 VAL C CB    1 
ATOM   558  C CG1   . VAL A 1 84  ? -18.747 -0.406  41.308 1.00 14.70 ? 101 VAL C CG1   1 
ATOM   559  C CG2   . VAL A 1 84  ? -18.399 -1.718  39.183 1.00 15.57 ? 101 VAL C CG2   1 
ATOM   560  N N     . GLY A 1 85  ? -15.252 0.624   41.563 1.00 16.12 ? 102 GLY C N     1 
ATOM   561  C CA    . GLY A 1 85  ? -14.680 1.447   42.611 1.00 14.93 ? 102 GLY C CA    1 
ATOM   562  C C     . GLY A 1 85  ? -14.193 2.774   42.067 1.00 14.25 ? 102 GLY C C     1 
ATOM   563  O O     . GLY A 1 85  ? -14.407 3.821   42.679 1.00 14.56 ? 102 GLY C O     1 
ATOM   564  N N     . TYR A 1 86  ? -13.554 2.742   40.901 1.00 15.59 ? 103 TYR C N     1 
ATOM   565  C CA    . TYR A 1 86  ? -13.044 3.959   40.271 1.00 15.62 ? 103 TYR C CA    1 
ATOM   566  C C     . TYR A 1 86  ? -14.179 4.924   39.960 1.00 14.60 ? 103 TYR C C     1 
ATOM   567  O O     . TYR A 1 86  ? -14.100 6.130   40.241 1.00 15.83 ? 103 TYR C O     1 
ATOM   568  C CB    . TYR A 1 86  ? -12.284 3.595   38.988 1.00 14.72 ? 103 TYR C CB    1 
ATOM   569  C CG    . TYR A 1 86  ? -11.808 4.811   38.222 1.00 16.21 ? 103 TYR C CG    1 
ATOM   570  C CD1   . TYR A 1 86  ? -10.625 5.441   38.564 1.00 15.87 ? 103 TYR C CD1   1 
ATOM   571  C CD2   . TYR A 1 86  ? -12.559 5.341   37.168 1.00 16.25 ? 103 TYR C CD2   1 
ATOM   572  C CE1   . TYR A 1 86  ? -10.176 6.588   37.869 1.00 17.23 ? 103 TYR C CE1   1 
ATOM   573  C CE2   . TYR A 1 86  ? -12.122 6.475   36.464 1.00 14.71 ? 103 TYR C CE2   1 
ATOM   574  C CZ    . TYR A 1 86  ? -10.938 7.092   36.819 1.00 19.29 ? 103 TYR C CZ    1 
ATOM   575  O OH    . TYR A 1 86  ? -10.492 8.223   36.146 1.00 17.74 ? 103 TYR C OH    1 
ATOM   576  N N     . GLU A 1 87  ? -15.254 4.404   39.378 1.00 14.81 ? 104 GLU C N     1 
ATOM   577  C CA    . GLU A 1 87  ? -16.426 5.227   39.100 1.00 16.14 ? 104 GLU C CA    1 
ATOM   578  C C     . GLU A 1 87  ? -17.004 5.823   40.377 1.00 15.34 ? 104 GLU C C     1 
ATOM   579  O O     . GLU A 1 87  ? -17.368 7.008   40.404 1.00 16.53 ? 104 GLU C O     1 
ATOM   580  C CB    . GLU A 1 87  ? -17.444 4.387   38.338 1.00 15.57 ? 104 GLU C CB    1 
ATOM   581  C CG    . GLU A 1 87  ? -16.849 4.018   36.978 1.00 19.09 ? 104 GLU C CG    1 
ATOM   582  C CD    . GLU A 1 87  ? -17.619 2.947   36.224 1.00 23.92 ? 104 GLU C CD    1 
ATOM   583  O OE1   . GLU A 1 87  ? -18.331 2.128   36.859 1.00 21.20 ? 104 GLU C OE1   1 
ATOM   584  O OE2   . GLU A 1 87  ? -17.448 2.867   34.987 1.00 23.52 ? 104 GLU C OE2   1 
ATOM   585  N N     . LEU A 1 88  ? -17.061 5.043   41.458 1.00 14.68 ? 105 LEU C N     1 
ATOM   586  C CA    . LEU A 1 88  ? -17.555 5.612   42.714 1.00 13.82 ? 105 LEU C CA    1 
ATOM   587  C C     . LEU A 1 88  ? -16.614 6.692   43.230 1.00 16.26 ? 105 LEU C C     1 
ATOM   588  O O     . LEU A 1 88  ? -17.064 7.695   43.805 1.00 15.05 ? 105 LEU C O     1 
ATOM   589  C CB    . LEU A 1 88  ? -17.751 4.508   43.759 1.00 14.82 ? 105 LEU C CB    1 
ATOM   590  C CG    . LEU A 1 88  ? -18.981 3.650   43.462 1.00 16.42 ? 105 LEU C CG    1 
ATOM   591  C CD1   . LEU A 1 88  ? -18.947 2.373   44.276 1.00 16.49 ? 105 LEU C CD1   1 
ATOM   592  C CD2   . LEU A 1 88  ? -20.296 4.418   43.735 1.00 16.96 ? 105 LEU C CD2   1 
ATOM   593  N N     . GLY A 1 89  ? -15.303 6.497   43.054 1.00 14.37 ? 106 GLY C N     1 
ATOM   594  C CA    . GLY A 1 89  ? -14.353 7.510   43.490 1.00 17.56 ? 106 GLY C CA    1 
ATOM   595  C C     . GLY A 1 89  ? -14.526 8.813   42.736 1.00 18.27 ? 106 GLY C C     1 
ATOM   596  O O     . GLY A 1 89  ? -14.559 9.891   43.337 1.00 15.88 ? 106 GLY C O     1 
ATOM   597  N N     . ARG A 1 90  ? -14.683 8.727   41.412 1.00 17.65 ? 107 ARG C N     1 
ATOM   598  C CA    . ARG A 1 90  ? -14.955 9.925   40.625 1.00 17.43 ? 107 ARG C CA    1 
ATOM   599  C C     . ARG A 1 90  ? -16.313 10.521  40.996 1.00 18.18 ? 107 ARG C C     1 
ATOM   600  O O     . ARG A 1 90  ? -16.454 11.744  41.075 1.00 18.98 ? 107 ARG C O     1 
ATOM   601  C CB    . ARG A 1 90  ? -14.898 9.602   39.135 1.00 16.03 ? 107 ARG C CB    1 
ATOM   602  C CG    . ARG A 1 90  ? -13.521 9.086   38.628 1.00 14.93 ? 107 ARG C CG    1 
ATOM   603  C CD    . ARG A 1 90  ? -12.355 10.030  38.888 1.00 17.58 ? 107 ARG C CD    1 
ATOM   604  N NE    . ARG A 1 90  ? -12.563 11.351  38.306 1.00 19.94 ? 107 ARG C NE    1 
ATOM   605  C CZ    . ARG A 1 90  ? -12.143 11.727  37.105 1.00 22.78 ? 107 ARG C CZ    1 
ATOM   606  N NH1   . ARG A 1 90  ? -11.569 10.872  36.268 1.00 21.76 ? 107 ARG C NH1   1 
ATOM   607  N NH2   . ARG A 1 90  ? -12.325 12.991  36.722 1.00 22.70 ? 107 ARG C NH2   1 
ATOM   608  N N     . ALA A 1 91  ? -17.320 9.673   41.241 1.00 17.45 ? 108 ALA C N     1 
ATOM   609  C CA    . ALA A 1 91  ? -18.641 10.177  41.623 1.00 18.65 ? 108 ALA C CA    1 
ATOM   610  C C     . ALA A 1 91  ? -18.590 10.933  42.939 1.00 21.42 ? 108 ALA C C     1 
ATOM   611  O O     . ALA A 1 91  ? -19.236 11.979  43.091 1.00 20.00 ? 108 ALA C O     1 
ATOM   612  C CB    . ALA A 1 91  ? -19.646 9.027   41.725 1.00 18.14 ? 108 ALA C CB    1 
ATOM   613  N N     . VAL A 1 92  ? -17.865 10.400  43.922 1.00 17.61 ? 109 VAL C N     1 
ATOM   614  C CA    . VAL A 1 92  ? -17.762 11.108  45.188 1.00 17.84 ? 109 VAL C CA    1 
ATOM   615  C C     . VAL A 1 92  ? -17.118 12.468  44.973 1.00 20.78 ? 109 VAL C C     1 
ATOM   616  O O     . VAL A 1 92  ? -17.597 13.490  45.481 1.00 25.69 ? 109 VAL C O     1 
ATOM   617  C CB    . VAL A 1 92  ? -16.983 10.266  46.212 1.00 20.83 ? 109 VAL C CB    1 
ATOM   618  C CG1   . VAL A 1 92  ? -16.596 11.120  47.416 1.00 21.05 ? 109 VAL C CG1   1 
ATOM   619  C CG2   . VAL A 1 92  ? -17.813 9.070   46.644 1.00 18.87 ? 109 VAL C CG2   1 
ATOM   620  N N     . ALA A 1 93  ? -16.017 12.505  44.219 1.00 19.89 ? 110 ALA C N     1 
ATOM   621  C CA    . ALA A 1 93  ? -15.317 13.772  44.008 1.00 20.23 ? 110 ALA C CA    1 
ATOM   622  C C     . ALA A 1 93  ? -16.173 14.766  43.235 1.00 25.00 ? 110 ALA C C     1 
ATOM   623  O O     . ALA A 1 93  ? -15.987 15.981  43.373 1.00 26.16 ? 110 ALA C O     1 
ATOM   624  C CB    . ALA A 1 93  ? -14.003 13.527  43.278 1.00 18.29 ? 110 ALA C CB    1 
ATOM   625  N N     . PHE A 1 94  ? -17.103 14.277  42.408 1.00 23.57 ? 111 PHE C N     1 
ATOM   626  C CA    . PHE A 1 94  ? -18.106 15.146  41.790 1.00 26.20 ? 111 PHE C CA    1 
ATOM   627  C C     . PHE A 1 94  ? -19.292 15.436  42.708 1.00 26.11 ? 111 PHE C C     1 
ATOM   628  O O     . PHE A 1 94  ? -20.248 16.074  42.258 1.00 28.53 ? 111 PHE C O     1 
ATOM   629  C CB    . PHE A 1 94  ? -18.638 14.534  40.480 1.00 23.62 ? 111 PHE C CB    1 
ATOM   630  C CG    . PHE A 1 94  ? -17.644 14.527  39.341 1.00 28.78 ? 111 PHE C CG    1 
ATOM   631  C CD1   . PHE A 1 94  ? -16.975 15.685  38.965 1.00 28.75 ? 111 PHE C CD1   1 
ATOM   632  C CD2   . PHE A 1 94  ? -17.413 13.366  38.624 1.00 24.58 ? 111 PHE C CD2   1 
ATOM   633  C CE1   . PHE A 1 94  ? -16.067 15.667  37.917 1.00 35.13 ? 111 PHE C CE1   1 
ATOM   634  C CE2   . PHE A 1 94  ? -16.507 13.336  37.566 1.00 29.98 ? 111 PHE C CE2   1 
ATOM   635  C CZ    . PHE A 1 94  ? -15.836 14.489  37.213 1.00 31.07 ? 111 PHE C CZ    1 
ATOM   636  N N     . ASN A 1 95  ? -19.279 14.960  43.958 1.00 22.25 ? 112 ASN C N     1 
ATOM   637  C CA    . ASN A 1 95  ? -20.382 15.159  44.910 1.00 26.70 ? 112 ASN C CA    1 
ATOM   638  C C     . ASN A 1 95  ? -21.723 14.697  44.342 1.00 28.64 ? 112 ASN C C     1 
ATOM   639  O O     . ASN A 1 95  ? -22.752 15.364  44.473 1.00 29.16 ? 112 ASN C O     1 
ATOM   640  C CB    . ASN A 1 95  ? -20.474 16.612  45.379 1.00 28.02 ? 112 ASN C CB    1 
ATOM   641  C CG    . ASN A 1 95  ? -21.267 16.743  46.675 1.00 38.91 ? 112 ASN C CG    1 
ATOM   642  O OD1   . ASN A 1 95  ? -21.121 15.929  47.595 1.00 42.27 ? 112 ASN C OD1   1 
ATOM   643  N ND2   . ASN A 1 95  ? -22.122 17.762  46.746 1.00 42.58 ? 112 ASN C ND2   1 
ATOM   644  N N     . LYS A 1 96  ? -21.706 13.521  43.734 1.00 19.96 ? 113 LYS C N     1 
ATOM   645  C CA    . LYS A 1 96  ? -22.909 12.947  43.160 1.00 19.80 ? 113 LYS C CA    1 
ATOM   646  C C     . LYS A 1 96  ? -23.738 12.296  44.257 1.00 25.23 ? 113 LYS C C     1 
ATOM   647  O O     . LYS A 1 96  ? -23.213 11.839  45.272 1.00 23.87 ? 113 LYS C O     1 
ATOM   648  C CB    . LYS A 1 96  ? -22.553 11.889  42.114 1.00 22.41 ? 113 LYS C CB    1 
ATOM   649  C CG    . LYS A 1 96  ? -21.939 12.469  40.841 1.00 26.01 ? 113 LYS C CG    1 
ATOM   650  C CD    . LYS A 1 96  ? -23.011 12.911  39.856 1.00 29.40 ? 113 LYS C CD    1 
ATOM   651  C CE    . LYS A 1 96  ? -22.489 14.007  38.951 1.00 33.37 ? 113 LYS C CE    1 
ATOM   652  N NZ    . LYS A 1 96  ? -23.621 14.767  38.330 1.00 33.05 ? 113 LYS C NZ    1 
ATOM   653  N N     . ARG A 1 97  ? -25.046 12.258  44.042 1.00 22.11 ? 114 ARG C N     1 
ATOM   654  C CA    . ARG A 1 97  ? -25.906 11.402  44.849 1.00 22.05 ? 114 ARG C CA    1 
ATOM   655  C C     . ARG A 1 97  ? -25.682 9.950   44.434 1.00 20.06 ? 114 ARG C C     1 
ATOM   656  O O     . ARG A 1 97  ? -25.744 9.624   43.245 1.00 19.78 ? 114 ARG C O     1 
ATOM   657  C CB    . ARG A 1 97  ? -27.362 11.828  44.662 1.00 21.77 ? 114 ARG C CB    1 
ATOM   658  C CG    . ARG A 1 97  ? -28.394 11.021  45.425 1.00 31.84 ? 114 ARG C CG    1 
ATOM   659  C CD    . ARG A 1 97  ? -29.742 11.766  45.348 1.00 36.78 ? 114 ARG C CD    1 
ATOM   660  N NE    . ARG A 1 97  ? -30.899 10.895  45.505 1.00 45.26 ? 114 ARG C NE    1 
ATOM   661  C CZ    . ARG A 1 97  ? -32.010 11.003  44.790 1.00 44.96 ? 114 ARG C CZ    1 
ATOM   662  N NH1   . ARG A 1 97  ? -32.132 11.919  43.839 1.00 45.26 ? 114 ARG C NH1   1 
ATOM   663  N NH2   . ARG A 1 97  ? -33.028 10.184  45.044 1.00 50.65 ? 114 ARG C NH2   1 
ATOM   664  N N     . ILE A 1 98  ? -25.374 9.086   45.408 1.00 19.22 ? 115 ILE C N     1 
ATOM   665  C CA    . ILE A 1 98  ? -24.897 7.733   45.140 1.00 17.97 ? 115 ILE C CA    1 
ATOM   666  C C     . ILE A 1 98  ? -25.715 6.722   45.928 1.00 21.74 ? 115 ILE C C     1 
ATOM   667  O O     . ILE A 1 98  ? -26.006 6.922   47.114 1.00 19.34 ? 115 ILE C O     1 
ATOM   668  C CB    . ILE A 1 98  ? -23.396 7.593   45.496 1.00 20.40 ? 115 ILE C CB    1 
ATOM   669  C CG1   . ILE A 1 98  ? -22.536 8.391   44.513 1.00 16.46 ? 115 ILE C CG1   1 
ATOM   670  C CG2   . ILE A 1 98  ? -22.966 6.104   45.549 1.00 17.28 ? 115 ILE C CG2   1 
ATOM   671  C CD1   . ILE A 1 98  ? -21.140 8.727   45.051 1.00 19.33 ? 115 ILE C CD1   1 
ATOM   672  N N     . LEU A 1 99  ? -26.066 5.624   45.267 1.00 21.21 ? 116 LEU C N     1 
ATOM   673  C CA    . LEU A 1 99  ? -26.742 4.493   45.889 1.00 21.74 ? 116 LEU C CA    1 
ATOM   674  C C     . LEU A 1 99  ? -25.941 3.237   45.589 1.00 22.10 ? 116 LEU C C     1 
ATOM   675  O O     . LEU A 1 99  ? -25.833 2.835   44.425 1.00 17.76 ? 116 LEU C O     1 
ATOM   676  C CB    . LEU A 1 99  ? -28.160 4.353   45.355 1.00 20.82 ? 116 LEU C CB    1 
ATOM   677  C CG    . LEU A 1 99  ? -28.832 3.032   45.724 1.00 22.46 ? 116 LEU C CG    1 
ATOM   678  C CD1   . LEU A 1 99  ? -28.981 2.896   47.238 1.00 23.40 ? 116 LEU C CD1   1 
ATOM   679  C CD2   . LEU A 1 99  ? -30.176 2.955   45.003 1.00 22.75 ? 116 LEU C CD2   1 
ATOM   680  N N     . CYS A 1 100 ? -25.379 2.620   46.620 1.00 18.58 ? 117 CYS C N     1 
ATOM   681  C CA    . CYS A 1 100 ? -24.596 1.397   46.468 1.00 19.96 ? 117 CYS C CA    1 
ATOM   682  C C     . CYS A 1 100 ? -25.397 0.212   46.981 1.00 23.05 ? 117 CYS C C     1 
ATOM   683  O O     . CYS A 1 100 ? -25.971 0.275   48.068 1.00 21.04 ? 117 CYS C O     1 
ATOM   684  C CB    . CYS A 1 100 ? -23.279 1.471   47.229 1.00 19.02 ? 117 CYS C CB    1 
ATOM   685  S SG    . CYS A 1 100 ? -22.066 2.517   46.418 1.00 21.25 ? 117 CYS C SG    1 
ATOM   686  N N     . LEU A 1 101 ? -25.411 -0.873  46.211 1.00 17.90 ? 118 LEU C N     1 
ATOM   687  C CA    . LEU A 1 101 ? -26.242 -2.031  46.514 1.00 16.57 ? 118 LEU C CA    1 
ATOM   688  C C     . LEU A 1 101 ? -25.318 -3.215  46.757 1.00 18.33 ? 118 LEU C C     1 
ATOM   689  O O     . LEU A 1 101 ? -24.538 -3.580  45.873 1.00 20.44 ? 118 LEU C O     1 
ATOM   690  C CB    . LEU A 1 101 ? -27.202 -2.322  45.359 1.00 19.78 ? 118 LEU C CB    1 
ATOM   691  C CG    . LEU A 1 101 ? -28.143 -1.173  45.024 1.00 20.40 ? 118 LEU C CG    1 
ATOM   692  C CD1   . LEU A 1 101 ? -29.007 -1.528  43.808 1.00 26.92 ? 118 LEU C CD1   1 
ATOM   693  C CD2   . LEU A 1 101 ? -29.021 -0.834  46.246 1.00 22.76 ? 118 LEU C CD2   1 
ATOM   694  N N     . PHE A 1 102 ? -25.400 -3.807  47.953 1.00 15.49 ? 119 PHE C N     1 
ATOM   695  C CA    . PHE A 1 102 ? -24.506 -4.890  48.341 1.00 17.56 ? 119 PHE C CA    1 
ATOM   696  C C     . PHE A 1 102 ? -25.308 -6.077  48.846 1.00 18.79 ? 119 PHE C C     1 
ATOM   697  O O     . PHE A 1 102 ? -26.235 -5.900  49.630 1.00 22.13 ? 119 PHE C O     1 
ATOM   698  C CB    . PHE A 1 102 ? -23.521 -4.445  49.451 1.00 17.44 ? 119 PHE C CB    1 
ATOM   699  C CG    . PHE A 1 102 ? -22.589 -5.528  49.870 1.00 15.87 ? 119 PHE C CG    1 
ATOM   700  C CD1   . PHE A 1 102 ? -21.593 -5.961  49.008 1.00 17.34 ? 119 PHE C CD1   1 
ATOM   701  C CD2   . PHE A 1 102 ? -22.729 -6.154  51.104 1.00 20.79 ? 119 PHE C CD2   1 
ATOM   702  C CE1   . PHE A 1 102 ? -20.731 -6.991  49.375 1.00 18.71 ? 119 PHE C CE1   1 
ATOM   703  C CE2   . PHE A 1 102 ? -21.874 -7.175  51.477 1.00 17.83 ? 119 PHE C CE2   1 
ATOM   704  C CZ    . PHE A 1 102 ? -20.876 -7.597  50.625 1.00 20.31 ? 119 PHE C CZ    1 
ATOM   705  N N     . ARG A 1 103 ? -24.915 -7.289  48.434 1.00 16.36 ? 120 ARG C N     1 
ATOM   706  C CA    . ARG A 1 103 ? -25.581 -8.517  48.870 1.00 20.69 ? 120 ARG C CA    1 
ATOM   707  C C     . ARG A 1 103 ? -24.670 -9.303  49.797 1.00 23.00 ? 120 ARG C C     1 
ATOM   708  O O     . ARG A 1 103 ? -23.753 -9.992  49.324 1.00 24.53 ? 120 ARG C O     1 
ATOM   709  C CB    . ARG A 1 103 ? -25.972 -9.380  47.664 1.00 22.89 ? 120 ARG C CB    1 
ATOM   710  C CG    . ARG A 1 103 ? -26.929 -8.673  46.745 1.00 24.73 ? 120 ARG C CG    1 
ATOM   711  C CD    . ARG A 1 103 ? -27.478 -9.562  45.640 1.00 27.36 ? 120 ARG C CD    1 
ATOM   712  N NE    . ARG A 1 103 ? -26.590 -10.645 45.229 1.00 25.56 ? 120 ARG C NE    1 
ATOM   713  C CZ    . ARG A 1 103 ? -25.622 -10.529 44.326 1.00 28.61 ? 120 ARG C CZ    1 
ATOM   714  N NH1   . ARG A 1 103 ? -25.311 -9.360  43.785 1.00 25.36 ? 120 ARG C NH1   1 
ATOM   715  N NH2   . ARG A 1 103 ? -24.938 -11.611 43.966 1.00 26.78 ? 120 ARG C NH2   1 
ATOM   716  N N     . PRO A 1 104 ? -24.881 -9.256  51.108 1.00 24.36 ? 121 PRO C N     1 
ATOM   717  C CA    . PRO A 1 104 ? -24.033 -10.030 52.017 1.00 26.82 ? 121 PRO C CA    1 
ATOM   718  C C     . PRO A 1 104 ? -24.100 -11.521 51.719 1.00 31.17 ? 121 PRO C C     1 
ATOM   719  O O     . PRO A 1 104 ? -25.116 -12.045 51.255 1.00 30.98 ? 121 PRO C O     1 
ATOM   720  C CB    . PRO A 1 104 ? -24.612 -9.695  53.395 1.00 28.25 ? 121 PRO C CB    1 
ATOM   721  C CG    . PRO A 1 104 ? -25.189 -8.337  53.200 1.00 27.61 ? 121 PRO C CG    1 
ATOM   722  C CD    . PRO A 1 104 ? -25.843 -8.432  51.844 1.00 24.36 ? 121 PRO C CD    1 
ATOM   723  N N     . GLN A 1 105 ? -22.975 -12.192 51.949 1.00 32.47 ? 122 GLN C N     1 
ATOM   724  C CA    . GLN A 1 105 ? -22.787 -13.595 51.595 1.00 37.98 ? 122 GLN C CA    1 
ATOM   725  C C     . GLN A 1 105 ? -21.698 -14.154 52.498 1.00 46.60 ? 122 GLN C C     1 
ATOM   726  O O     . GLN A 1 105 ? -20.756 -13.435 52.845 1.00 42.11 ? 122 GLN C O     1 
ATOM   727  C CB    . GLN A 1 105 ? -22.372 -13.782 50.124 1.00 38.57 ? 122 GLN C CB    1 
ATOM   728  C CG    . GLN A 1 105 ? -23.351 -13.257 49.078 1.00 40.03 ? 122 GLN C CG    1 
ATOM   729  C CD    . GLN A 1 105 ? -22.676 -12.409 48.006 1.00 37.05 ? 122 GLN C CD    1 
ATOM   730  O OE1   . GLN A 1 105 ? -21.845 -11.547 48.308 0.57 35.24 ? 122 GLN C OE1   1 
ATOM   731  N NE2   . GLN A 1 105 ? -23.056 -12.629 46.753 0.53 36.81 ? 122 GLN C NE2   1 
ATOM   732  N N     . SER A 1 106 ? -21.826 -15.432 52.867 1.00 45.11 ? 123 SER C N     1 
ATOM   733  C CA    . SER A 1 106 ? -20.761 -16.121 53.589 1.00 53.80 ? 123 SER C CA    1 
ATOM   734  C C     . SER A 1 106 ? -19.432 -15.966 52.862 1.00 51.73 ? 123 SER C C     1 
ATOM   735  O O     . SER A 1 106 ? -19.272 -16.440 51.734 1.00 53.05 ? 123 SER C O     1 
ATOM   736  C CB    . SER A 1 106 ? -21.102 -17.605 53.741 1.00 54.78 ? 123 SER C CB    1 
ATOM   737  O OG    . SER A 1 106 ? -21.924 -17.835 54.869 1.00 60.86 ? 123 SER C OG    1 
ATOM   738  N N     . GLY A 1 107 ? -18.485 -15.278 53.505 1.00 50.84 ? 124 GLY C N     1 
ATOM   739  C CA    . GLY A 1 107 ? -17.165 -15.079 52.945 1.00 51.63 ? 124 GLY C CA    1 
ATOM   740  C C     . GLY A 1 107 ? -16.964 -13.805 52.145 1.00 49.87 ? 124 GLY C C     1 
ATOM   741  O O     . GLY A 1 107 ? -15.835 -13.552 51.701 1.00 50.01 ? 124 GLY C O     1 
ATOM   742  N N     . ARG A 1 108 ? -18.006 -12.991 51.950 1.00 44.79 ? 125 ARG C N     1 
ATOM   743  C CA    . ARG A 1 108 ? -17.916 -11.780 51.137 1.00 44.84 ? 125 ARG C CA    1 
ATOM   744  C C     . ARG A 1 108 ? -18.267 -10.561 51.981 1.00 38.89 ? 125 ARG C C     1 
ATOM   745  O O     . ARG A 1 108 ? -19.401 -10.434 52.462 1.00 38.60 ? 125 ARG C O     1 
ATOM   746  C CB    . ARG A 1 108 ? -18.827 -11.869 49.912 1.00 43.99 ? 125 ARG C CB    1 
ATOM   747  C CG    . ARG A 1 108 ? -18.936 -10.562 49.126 1.00 39.24 ? 125 ARG C CG    1 
ATOM   748  C CD    . ARG A 1 108 ? -17.786 -10.271 48.156 1.00 46.75 ? 125 ARG C CD    1 
ATOM   749  N NE    . ARG A 1 108 ? -17.958 -10.951 46.877 1.00 48.32 ? 125 ARG C NE    1 
ATOM   750  C CZ    . ARG A 1 108 ? -17.034 -11.691 46.279 1.00 44.56 ? 125 ARG C CZ    1 
ATOM   751  N NH1   . ARG A 1 108 ? -15.808 -11.799 46.770 1.00 48.93 ? 125 ARG C NH1   1 
ATOM   752  N NH2   . ARG A 1 108 ? -17.340 -12.319 45.146 1.00 46.47 ? 125 ARG C NH2   1 
ATOM   753  N N     . VAL A 1 109 ? -17.298 -9.658  52.135 1.00 34.60 ? 126 VAL C N     1 
ATOM   754  C CA    . VAL A 1 109 ? -17.426 -8.452  52.948 1.00 29.12 ? 126 VAL C CA    1 
ATOM   755  C C     . VAL A 1 109 ? -17.159 -7.238  52.062 1.00 20.94 ? 126 VAL C C     1 
ATOM   756  O O     . VAL A 1 109 ? -16.187 -7.226  51.297 1.00 21.95 ? 126 VAL C O     1 
ATOM   757  C CB    . VAL A 1 109 ? -16.452 -8.470  54.140 1.00 30.76 ? 126 VAL C CB    1 
ATOM   758  C CG1   . VAL A 1 109 ? -16.736 -7.303  55.057 1.00 27.59 ? 126 VAL C CG1   1 
ATOM   759  C CG2   . VAL A 1 109 ? -16.564 -9.787  54.906 1.00 35.97 ? 126 VAL C CG2   1 
ATOM   760  N N     . LEU A 1 110 ? -18.013 -6.228  52.174 1.00 21.02 ? 127 LEU C N     1 
ATOM   761  C CA    . LEU A 1 110 ? -17.893 -5.048  51.337 1.00 19.94 ? 127 LEU C CA    1 
ATOM   762  C C     . LEU A 1 110 ? -16.683 -4.230  51.761 1.00 19.36 ? 127 LEU C C     1 
ATOM   763  O O     . LEU A 1 110 ? -16.477 -3.983  52.956 1.00 18.64 ? 127 LEU C O     1 
ATOM   764  C CB    . LEU A 1 110 ? -19.155 -4.194  51.429 1.00 18.09 ? 127 LEU C CB    1 
ATOM   765  C CG    . LEU A 1 110 ? -19.147 -2.899  50.616 1.00 17.97 ? 127 LEU C CG    1 
ATOM   766  C CD1   . LEU A 1 110 ? -18.935 -3.230  49.140 1.00 16.75 ? 127 LEU C CD1   1 
ATOM   767  C CD2   . LEU A 1 110 ? -20.450 -2.128  50.828 1.00 18.20 ? 127 LEU C CD2   1 
ATOM   768  N N     . SER A 1 111 ? -15.894 -3.821  50.768 1.00 17.92 ? 128 SER C N     1 
ATOM   769  C CA    . SER A 1 111 ? -14.768 -2.912  50.935 1.00 16.49 ? 128 SER C CA    1 
ATOM   770  C C     . SER A 1 111 ? -15.036 -1.830  51.975 1.00 17.19 ? 128 SER C C     1 
ATOM   771  O O     . SER A 1 111 ? -16.059 -1.153  51.930 1.00 17.04 ? 128 SER C O     1 
ATOM   772  C CB    . SER A 1 111 ? -14.465 -2.258  49.589 1.00 16.22 ? 128 SER C CB    1 
ATOM   773  O OG    . SER A 1 111 ? -13.451 -1.269  49.711 1.00 16.35 ? 128 SER C OG    1 
ATOM   774  N N     . ALA A 1 112 ? -14.065 -1.627  52.877 1.00 16.45 ? 129 ALA C N     1 
ATOM   775  C CA    . ALA A 1 112 ? -14.171 -0.551  53.847 1.00 18.76 ? 129 ALA C CA    1 
ATOM   776  C C     . ALA A 1 112 ? -14.158 0.816   53.170 1.00 18.85 ? 129 ALA C C     1 
ATOM   777  O O     . ALA A 1 112 ? -14.692 1.780   53.721 1.00 17.65 ? 129 ALA C O     1 
ATOM   778  C CB    . ALA A 1 112 ? -13.029 -0.658  54.856 1.00 19.23 ? 129 ALA C CB    1 
ATOM   779  N N     . MET A 1 113 ? -13.599 0.917   51.960 1.00 17.62 ? 130 MET C N     1 
ATOM   780  C CA    . MET A 1 113 ? -13.552 2.206   51.281 1.00 17.44 ? 130 MET C CA    1 
ATOM   781  C C     . MET A 1 113 ? -14.922 2.612   50.773 1.00 21.61 ? 130 MET C C     1 
ATOM   782  O O     . MET A 1 113 ? -15.211 3.805   50.659 1.00 24.28 ? 130 MET C O     1 
ATOM   783  C CB    . MET A 1 113 ? -12.574 2.134   50.116 1.00 20.11 ? 130 MET C CB    1 
ATOM   784  C CG    . MET A 1 113 ? -11.089 2.157   50.505 1.00 17.89 ? 130 MET C CG    1 
ATOM   785  S SD    . MET A 1 113 ? -10.649 3.255   51.854 1.00 19.26 ? 130 MET C SD    1 
ATOM   786  C CE    . MET A 1 113 ? -10.387 4.772   50.958 1.00 19.81 ? 130 MET C CE    1 
ATOM   787  N N     . ILE A 1 114 ? -15.766 1.640   50.453 1.00 15.64 ? 131 ILE C N     1 
ATOM   788  C CA    . ILE A 1 114 ? -17.128 1.918   50.020 1.00 16.25 ? 131 ILE C CA    1 
ATOM   789  C C     . ILE A 1 114 ? -18.058 2.045   51.204 1.00 18.62 ? 131 ILE C C     1 
ATOM   790  O O     . ILE A 1 114 ? -18.835 2.998   51.293 1.00 19.78 ? 131 ILE C O     1 
ATOM   791  C CB    . ILE A 1 114 ? -17.617 0.826   49.048 1.00 17.53 ? 131 ILE C CB    1 
ATOM   792  C CG1   . ILE A 1 114 ? -16.668 0.676   47.866 1.00 18.61 ? 131 ILE C CG1   1 
ATOM   793  C CG2   . ILE A 1 114 ? -18.999 1.176   48.521 1.00 20.71 ? 131 ILE C CG2   1 
ATOM   794  C CD1   . ILE A 1 114 ? -16.344 2.002   47.140 1.00 21.13 ? 131 ILE C CD1   1 
ATOM   795  N N     . ARG A 1 115 ? -18.007 1.086   52.131 1.00 17.76 ? 132 ARG C N     1 
ATOM   796  C CA    . ARG A 1 115 ? -18.858 1.219   53.307 1.00 19.97 ? 132 ARG C CA    1 
ATOM   797  C C     . ARG A 1 115 ? -18.494 2.462   54.110 1.00 18.58 ? 132 ARG C C     1 
ATOM   798  O O     . ARG A 1 115 ? -19.381 3.181   54.592 1.00 21.18 ? 132 ARG C O     1 
ATOM   799  C CB    . ARG A 1 115 ? -18.789 -0.035  54.183 1.00 22.29 ? 132 ARG C CB    1 
ATOM   800  C CG    . ARG A 1 115 ? -20.098 -0.195  54.963 1.00 27.72 ? 132 ARG C CG    1 
ATOM   801  C CD    . ARG A 1 115 ? -20.262 -1.530  55.677 1.00 26.25 ? 132 ARG C CD    1 
ATOM   802  N NE    . ARG A 1 115 ? -20.612 -2.655  54.821 1.00 23.16 ? 132 ARG C NE    1 
ATOM   803  C CZ    . ARG A 1 115 ? -21.850 -2.949  54.446 1.00 25.50 ? 132 ARG C CZ    1 
ATOM   804  N NH1   . ARG A 1 115 ? -22.840 -2.085  54.605 1.00 24.39 ? 132 ARG C NH1   1 
ATOM   805  N NH2   . ARG A 1 115 ? -22.094 -4.127  53.875 1.00 24.23 ? 132 ARG C NH2   1 
ATOM   806  N N     . GLY A 1 116 ? -17.191 2.754   54.236 1.00 19.08 ? 133 GLY C N     1 
ATOM   807  C CA    . GLY A 1 116 ? -16.745 3.924   54.977 1.00 17.88 ? 133 GLY C CA    1 
ATOM   808  C C     . GLY A 1 116 ? -17.045 5.249   54.304 1.00 20.50 ? 133 GLY C C     1 
ATOM   809  O O     . GLY A 1 116 ? -17.032 6.288   54.971 1.00 25.86 ? 133 GLY C O     1 
ATOM   810  N N     . ALA A 1 117 ? -17.316 5.241   52.999 1.00 20.15 ? 134 ALA C N     1 
ATOM   811  C CA    . ALA A 1 117 ? -17.668 6.468   52.299 1.00 20.38 ? 134 ALA C CA    1 
ATOM   812  C C     . ALA A 1 117 ? -19.115 6.876   52.556 1.00 21.54 ? 134 ALA C C     1 
ATOM   813  O O     . ALA A 1 117 ? -19.488 8.016   52.266 1.00 25.79 ? 134 ALA C O     1 
ATOM   814  C CB    . ALA A 1 117 ? -17.432 6.299   50.793 1.00 23.00 ? 134 ALA C CB    1 
ATOM   815  N N     . ALA A 1 118 ? -19.928 5.973   53.089 1.00 26.71 ? 135 ALA C N     1 
ATOM   816  C CA    . ALA A 1 118 ? -21.357 6.210   53.198 1.00 25.05 ? 135 ALA C CA    1 
ATOM   817  C C     . ALA A 1 118 ? -21.665 7.228   54.288 1.00 27.06 ? 135 ALA C C     1 
ATOM   818  O O     . ALA A 1 118 ? -20.966 7.332   55.300 1.00 28.37 ? 135 ALA C O     1 
ATOM   819  C CB    . ALA A 1 118 ? -22.084 4.899   53.485 1.00 25.62 ? 135 ALA C CB    1 
ATOM   820  N N     . ASP A 1 119 ? -22.741 7.979   54.074 1.00 26.99 ? 136 ASP C N     1 
ATOM   821  C CA    . ASP A 1 119 ? -23.222 8.931   55.058 1.00 29.21 ? 136 ASP C CA    1 
ATOM   822  C C     . ASP A 1 119 ? -24.712 8.805   55.362 1.00 32.85 ? 136 ASP C C     1 
ATOM   823  O O     . ASP A 1 119 ? -25.229 9.587   56.166 1.00 35.65 ? 136 ASP C O     1 
ATOM   824  C CB    . ASP A 1 119 ? -22.871 10.356  54.606 1.00 29.71 ? 136 ASP C CB    1 
ATOM   825  C CG    . ASP A 1 119 ? -23.584 10.768  53.330 1.00 32.01 ? 136 ASP C CG    1 
ATOM   826  O OD1   . ASP A 1 119 ? -24.551 10.096  52.913 1.00 29.08 ? 136 ASP C OD1   1 
ATOM   827  O OD2   . ASP A 1 119 ? -23.169 11.783  52.736 1.00 35.11 ? 136 ASP C OD2   1 
ATOM   828  N N     . GLY A 1 120 ? -25.409 7.836   54.761 1.00 31.38 ? 137 GLY C N     1 
ATOM   829  C CA    . GLY A 1 120 ? -26.824 7.635   55.010 1.00 33.11 ? 137 GLY C CA    1 
ATOM   830  C C     . GLY A 1 120 ? -27.755 8.574   54.275 1.00 35.16 ? 137 GLY C C     1 
ATOM   831  O O     . GLY A 1 120 ? -28.980 8.427   54.405 1.00 30.97 ? 137 GLY C O     1 
ATOM   832  N N     . SER A 1 121 ? -27.225 9.538   53.510 1.00 33.88 ? 138 SER C N     1 
ATOM   833  C CA    . SER A 1 121 ? -28.077 10.461  52.763 1.00 31.48 ? 138 SER C CA    1 
ATOM   834  C C     . SER A 1 121 ? -27.620 10.584  51.311 1.00 32.79 ? 138 SER C C     1 
ATOM   835  O O     . SER A 1 121 ? -28.198 9.955   50.419 1.00 28.70 ? 138 SER C O     1 
ATOM   836  C CB    . SER A 1 121 ? -28.113 11.842  53.432 1.00 37.95 ? 138 SER C CB    1 
ATOM   837  O OG    . SER A 1 121 ? -26.822 12.430  53.487 1.00 43.26 ? 138 SER C OG    1 
ATOM   838  N N     . ARG A 1 122 ? -26.587 11.395  51.062 1.00 29.44 ? 139 ARG C N     1 
ATOM   839  C CA    . ARG A 1 122 ? -26.091 11.576  49.699 1.00 27.83 ? 139 ARG C CA    1 
ATOM   840  C C     . ARG A 1 122 ? -25.370 10.327  49.183 1.00 28.75 ? 139 ARG C C     1 
ATOM   841  O O     . ARG A 1 122 ? -25.440 10.021  47.987 1.00 25.37 ? 139 ARG C O     1 
ATOM   842  C CB    . ARG A 1 122 ? -25.167 12.798  49.648 1.00 30.09 ? 139 ARG C CB    1 
ATOM   843  C CG    . ARG A 1 122 ? -24.726 13.203  48.244 1.00 36.85 ? 139 ARG C CG    1 
ATOM   844  C CD    . ARG A 1 122 ? -24.598 14.718  48.108 1.00 40.90 ? 139 ARG C CD    1 
ATOM   845  N NE    . ARG A 1 122 ? -24.543 15.141  46.712 1.00 40.27 ? 139 ARG C NE    1 
ATOM   846  C CZ    . ARG A 1 122 ? -25.608 15.333  45.945 1.00 38.36 ? 139 ARG C CZ    1 
ATOM   847  N NH1   . ARG A 1 122 ? -26.837 15.222  46.426 1.00 42.38 ? 139 ARG C NH1   1 
ATOM   848  N NH2   . ARG A 1 122 ? -25.438 15.664  44.669 1.00 39.69 ? 139 ARG C NH2   1 
ATOM   849  N N     . PHE A 1 123 ? -24.699 9.584   50.062 1.00 23.88 ? 140 PHE C N     1 
ATOM   850  C CA    . PHE A 1 123 ? -24.023 8.326   49.725 1.00 23.57 ? 140 PHE C CA    1 
ATOM   851  C C     . PHE A 1 123 ? -24.612 7.252   50.625 1.00 24.21 ? 140 PHE C C     1 
ATOM   852  O O     . PHE A 1 123 ? -24.315 7.216   51.823 1.00 24.65 ? 140 PHE C O     1 
ATOM   853  C CB    . PHE A 1 123 ? -22.507 8.446   49.919 1.00 23.12 ? 140 PHE C CB    1 
ATOM   854  C CG    . PHE A 1 123 ? -21.694 7.286   49.351 1.00 23.96 ? 140 PHE C CG    1 
ATOM   855  C CD1   . PHE A 1 123 ? -22.052 5.959   49.576 1.00 23.39 ? 140 PHE C CD1   1 
ATOM   856  C CD2   . PHE A 1 123 ? -20.561 7.543   48.582 1.00 22.68 ? 140 PHE C CD2   1 
ATOM   857  C CE1   . PHE A 1 123 ? -21.284 4.898   49.034 1.00 22.96 ? 140 PHE C CE1   1 
ATOM   858  C CE2   . PHE A 1 123 ? -19.810 6.512   48.040 1.00 19.62 ? 140 PHE C CE2   1 
ATOM   859  C CZ    . PHE A 1 123 ? -20.173 5.188   48.262 1.00 22.09 ? 140 PHE C CZ    1 
ATOM   860  N N     . GLN A 1 124 ? -25.429 6.379   50.050 1.00 21.79 ? 141 GLN C N     1 
ATOM   861  C CA    . GLN A 1 124 ? -26.138 5.353   50.798 1.00 19.80 ? 141 GLN C CA    1 
ATOM   862  C C     . GLN A 1 124 ? -25.666 3.973   50.360 1.00 21.62 ? 141 GLN C C     1 
ATOM   863  O O     . GLN A 1 124 ? -25.515 3.708   49.164 1.00 24.47 ? 141 GLN C O     1 
ATOM   864  C CB    . GLN A 1 124 ? -27.651 5.468   50.576 1.00 22.85 ? 141 GLN C CB    1 
ATOM   865  C CG    . GLN A 1 124 ? -28.252 6.705   51.213 1.00 25.88 ? 141 GLN C CG    1 
ATOM   866  C CD    . GLN A 1 124 ? -29.734 6.831   50.920 1.00 29.16 ? 141 GLN C CD    1 
ATOM   867  O OE1   . GLN A 1 124 ? -30.460 5.835   50.914 1.00 32.14 ? 141 GLN C OE1   1 
ATOM   868  N NE2   . GLN A 1 124 ? -30.191 8.055   50.692 1.00 28.33 ? 141 GLN C NE2   1 
ATOM   869  N N     . VAL A 1 125 ? -25.436 3.094   51.327 1.00 18.19 ? 142 VAL C N     1 
ATOM   870  C CA    . VAL A 1 125 ? -25.122 1.696   51.062 1.00 16.95 ? 142 VAL C CA    1 
ATOM   871  C C     . VAL A 1 125 ? -26.289 0.892   51.596 1.00 24.94 ? 142 VAL C C     1 
ATOM   872  O O     . VAL A 1 125 ? -26.660 1.040   52.762 1.00 24.52 ? 142 VAL C O     1 
ATOM   873  C CB    . VAL A 1 125 ? -23.811 1.263   51.732 1.00 23.69 ? 142 VAL C CB    1 
ATOM   874  C CG1   . VAL A 1 125 ? -23.597 -0.258  51.572 1.00 23.30 ? 142 VAL C CG1   1 
ATOM   875  C CG2   . VAL A 1 125 ? -22.631 2.065   51.173 1.00 20.94 ? 142 VAL C CG2   1 
ATOM   876  N N     . TRP A 1 126 ? -26.905 0.092   50.743 1.00 22.27 ? 143 TRP C N     1 
ATOM   877  C CA    . TRP A 1 126 ? -28.006 -0.771  51.153 1.00 22.05 ? 143 TRP C CA    1 
ATOM   878  C C     . TRP A 1 126 ? -27.552 -2.214  51.046 1.00 22.41 ? 143 TRP C C     1 
ATOM   879  O O     . TRP A 1 126 ? -27.121 -2.638  49.968 1.00 18.71 ? 143 TRP C O     1 
ATOM   880  C CB    . TRP A 1 126 ? -29.225 -0.560  50.260 1.00 22.74 ? 143 TRP C CB    1 
ATOM   881  C CG    . TRP A 1 126 ? -30.014 0.627   50.577 1.00 24.93 ? 143 TRP C CG    1 
ATOM   882  C CD1   . TRP A 1 126 ? -29.669 1.926   50.350 1.00 25.53 ? 143 TRP C CD1   1 
ATOM   883  C CD2   . TRP A 1 126 ? -31.312 0.650   51.179 1.00 27.47 ? 143 TRP C CD2   1 
ATOM   884  N NE1   . TRP A 1 126 ? -30.674 2.763   50.780 1.00 29.76 ? 143 TRP C NE1   1 
ATOM   885  C CE2   . TRP A 1 126 ? -31.695 2.002   51.292 1.00 29.99 ? 143 TRP C CE2   1 
ATOM   886  C CE3   . TRP A 1 126 ? -32.182 -0.348  51.652 1.00 26.90 ? 143 TRP C CE3   1 
ATOM   887  C CZ2   . TRP A 1 126 ? -32.915 2.390   51.847 1.00 31.11 ? 143 TRP C CZ2   1 
ATOM   888  C CZ3   . TRP A 1 126 ? -33.387 0.032   52.196 1.00 23.95 ? 143 TRP C CZ3   1 
ATOM   889  C CH2   . TRP A 1 126 ? -33.748 1.392   52.286 1.00 30.26 ? 143 TRP C CH2   1 
ATOM   890  N N     . ASP A 1 127 ? -27.664 -2.964  52.151 1.00 17.99 ? 144 ASP C N     1 
ATOM   891  C CA    . ASP A 1 127 ? -27.518 -4.415  52.118 1.00 19.21 ? 144 ASP C CA    1 
ATOM   892  C C     . ASP A 1 127 ? -28.850 -5.060  51.747 1.00 24.99 ? 144 ASP C C     1 
ATOM   893  O O     . ASP A 1 127 ? -29.885 -4.748  52.347 1.00 24.37 ? 144 ASP C O     1 
ATOM   894  C CB    . ASP A 1 127 ? -27.051 -4.955  53.477 1.00 20.00 ? 144 ASP C CB    1 
ATOM   895  C CG    . ASP A 1 127 ? -25.639 -4.520  53.838 1.00 27.75 ? 144 ASP C CG    1 
ATOM   896  O OD1   . ASP A 1 127 ? -24.829 -4.319  52.917 1.00 25.79 ? 144 ASP C OD1   1 
ATOM   897  O OD2   . ASP A 1 127 ? -25.339 -4.399  55.044 1.00 31.05 ? 144 ASP C OD2   1 
ATOM   898  N N     . TYR A 1 128 ? -28.826 -5.970  50.777 1.00 22.31 ? 145 TYR C N     1 
ATOM   899  C CA    . TYR A 1 128 ? -30.067 -6.548  50.270 1.00 20.83 ? 145 TYR C CA    1 
ATOM   900  C C     . TYR A 1 128 ? -29.774 -7.932  49.717 1.00 23.30 ? 145 TYR C C     1 
ATOM   901  O O     . TYR A 1 128 ? -28.618 -8.358  49.626 1.00 23.58 ? 145 TYR C O     1 
ATOM   902  C CB    . TYR A 1 128 ? -30.679 -5.640  49.194 1.00 21.30 ? 145 TYR C CB    1 
ATOM   903  C CG    . TYR A 1 128 ? -29.994 -5.819  47.866 1.00 21.98 ? 145 TYR C CG    1 
ATOM   904  C CD1   . TYR A 1 128 ? -28.720 -5.289  47.638 1.00 21.38 ? 145 TYR C CD1   1 
ATOM   905  C CD2   . TYR A 1 128 ? -30.607 -6.530  46.842 1.00 24.74 ? 145 TYR C CD2   1 
ATOM   906  C CE1   . TYR A 1 128 ? -28.079 -5.467  46.411 1.00 22.70 ? 145 TYR C CE1   1 
ATOM   907  C CE2   . TYR A 1 128 ? -29.976 -6.725  45.622 1.00 24.22 ? 145 TYR C CE2   1 
ATOM   908  C CZ    . TYR A 1 128 ? -28.717 -6.192  45.411 1.00 23.36 ? 145 TYR C CZ    1 
ATOM   909  O OH    . TYR A 1 128 ? -28.124 -6.405  44.192 1.00 24.13 ? 145 TYR C OH    1 
ATOM   910  N N     . GLU A 1 129 ? -30.838 -8.649  49.359 1.00 23.86 ? 146 GLU C N     1 
ATOM   911  C CA    . GLU A 1 129 ? -30.687 -9.911  48.647 1.00 27.14 ? 146 GLU C CA    1 
ATOM   912  C C     . GLU A 1 129 ? -31.540 -9.847  47.386 1.00 25.48 ? 146 GLU C C     1 
ATOM   913  O O     . GLU A 1 129 ? -32.449 -9.020  47.281 1.00 23.40 ? 146 GLU C O     1 
ATOM   914  C CB    . GLU A 1 129 ? -31.067 -11.118 49.523 1.00 28.76 ? 146 GLU C CB    1 
ATOM   915  C CG    . GLU A 1 129 ? -30.069 -11.419 50.662 1.00 32.26 ? 146 GLU C CG    1 
ATOM   916  C CD    . GLU A 1 129 ? -28.600 -11.587 50.255 1.00 32.48 ? 146 GLU C CD    1 
ATOM   917  O OE1   . GLU A 1 129 ? -28.279 -11.919 49.085 1.00 31.52 ? 146 GLU C OE1   1 
ATOM   918  O OE2   . GLU A 1 129 ? -27.744 -11.367 51.135 1.00 31.24 ? 146 GLU C OE2   1 
ATOM   919  N N     . GLU A 1 130 ? -31.208 -10.716 46.418 1.00 28.60 ? 147 GLU C N     1 
ATOM   920  C CA    . GLU A 1 130 ? -31.687 -10.545 45.043 1.00 30.11 ? 147 GLU C CA    1 
ATOM   921  C C     . GLU A 1 130 ? -33.193 -10.374 44.973 1.00 30.77 ? 147 GLU C C     1 
ATOM   922  O O     . GLU A 1 130 ? -33.698 -9.534  44.216 1.00 31.82 ? 147 GLU C O     1 
ATOM   923  C CB    . GLU A 1 130 ? -31.280 -11.746 44.185 1.00 32.19 ? 147 GLU C CB    1 
ATOM   924  C CG    . GLU A 1 130 ? -29.856 -12.191 44.378 1.00 40.06 ? 147 GLU C CG    1 
ATOM   925  C CD    . GLU A 1 130 ? -29.330 -12.994 43.207 0.19 41.74 ? 147 GLU C CD    1 
ATOM   926  O OE1   . GLU A 1 130 ? -28.100 -12.996 42.990 0.78 41.64 ? 147 GLU C OE1   1 
ATOM   927  O OE2   . GLU A 1 130 ? -30.151 -13.634 42.515 0.91 45.69 ? 147 GLU C OE2   1 
ATOM   928  N N     . GLY A 1 131 ? -33.929 -11.179 45.740 1.00 28.44 ? 148 GLY C N     1 
ATOM   929  C CA    . GLY A 1 131 ? -35.376 -11.170 45.630 1.00 30.80 ? 148 GLY C CA    1 
ATOM   930  C C     . GLY A 1 131 ? -36.015 -9.810  45.840 1.00 34.17 ? 148 GLY C C     1 
ATOM   931  O O     . GLY A 1 131 ? -37.110 -9.559  45.332 1.00 36.96 ? 148 GLY C O     1 
ATOM   932  N N     . GLU A 1 132 ? -35.359 -8.907  46.579 1.00 29.50 ? 149 GLU C N     1 
ATOM   933  C CA    . GLU A 1 132 ? -36.013 -7.653  46.938 1.00 26.18 ? 149 GLU C CA    1 
ATOM   934  C C     . GLU A 1 132 ? -35.508 -6.442  46.147 1.00 24.59 ? 149 GLU C C     1 
ATOM   935  O O     . GLU A 1 132 ? -35.878 -5.306  46.462 1.00 26.33 ? 149 GLU C O     1 
ATOM   936  C CB    . GLU A 1 132 ? -35.865 -7.371  48.434 1.00 33.23 ? 149 GLU C CB    1 
ATOM   937  C CG    . GLU A 1 132 ? -34.452 -7.141  48.876 1.00 31.81 ? 149 GLU C CG    1 
ATOM   938  C CD    . GLU A 1 132 ? -34.284 -7.109  50.390 1.00 34.39 ? 149 GLU C CD    1 
ATOM   939  O OE1   . GLU A 1 132 ? -33.202 -7.510  50.868 1.00 33.67 ? 149 GLU C OE1   1 
ATOM   940  O OE2   . GLU A 1 132 ? -35.231 -6.676  51.100 1.00 40.55 ? 149 GLU C OE2   1 
ATOM   941  N N     . VAL A 1 133 ? -34.716 -6.647  45.102 1.00 26.98 ? 150 VAL C N     1 
ATOM   942  C CA    . VAL A 1 133 ? -34.052 -5.497  44.501 1.00 28.06 ? 150 VAL C CA    1 
ATOM   943  C C     . VAL A 1 133 ? -35.055 -4.553  43.838 1.00 26.69 ? 150 VAL C C     1 
ATOM   944  O O     . VAL A 1 133 ? -34.923 -3.330  43.941 1.00 26.51 ? 150 VAL C O     1 
ATOM   945  C CB    . VAL A 1 133 ? -32.955 -5.964  43.530 1.00 30.35 ? 150 VAL C CB    1 
ATOM   946  C CG1   . VAL A 1 133 ? -33.562 -6.577  42.291 1.00 29.79 ? 150 VAL C CG1   1 
ATOM   947  C CG2   . VAL A 1 133 ? -32.053 -4.786  43.184 1.00 30.44 ? 150 VAL C CG2   1 
ATOM   948  N N     . GLU A 1 134 ? -36.088 -5.087  43.176 1.00 30.55 ? 151 GLU C N     1 
ATOM   949  C CA    . GLU A 1 134 ? -37.071 -4.200  42.555 1.00 31.78 ? 151 GLU C CA    1 
ATOM   950  C C     . GLU A 1 134 ? -37.814 -3.379  43.602 1.00 31.07 ? 151 GLU C C     1 
ATOM   951  O O     . GLU A 1 134 ? -38.038 -2.178  43.416 1.00 29.52 ? 151 GLU C O     1 
ATOM   952  C CB    . GLU A 1 134 ? -38.061 -5.003  41.714 1.00 37.16 ? 151 GLU C CB    1 
ATOM   953  C CG    . GLU A 1 134 ? -37.497 -5.447  40.378 1.00 35.81 ? 151 GLU C CG    1 
ATOM   954  C CD    . GLU A 1 134 ? -36.920 -6.838  40.450 1.00 44.67 ? 151 GLU C CD    1 
ATOM   955  O OE1   . GLU A 1 134 ? -36.540 -7.385  39.391 1.00 47.39 ? 151 GLU C OE1   1 
ATOM   956  O OE2   . GLU A 1 134 ? -36.844 -7.382  41.574 1.00 45.45 ? 151 GLU C OE2   1 
ATOM   957  N N     . ALA A 1 135 ? -38.191 -4.009  44.715 1.00 28.29 ? 152 ALA C N     1 
ATOM   958  C CA    . ALA A 1 135 ? -38.857 -3.275  45.785 1.00 26.85 ? 152 ALA C CA    1 
ATOM   959  C C     . ALA A 1 135 ? -37.950 -2.192  46.364 1.00 26.20 ? 152 ALA C C     1 
ATOM   960  O O     . ALA A 1 135 ? -38.405 -1.080  46.657 1.00 24.50 ? 152 ALA C O     1 
ATOM   961  C CB    . ALA A 1 135 ? -39.304 -4.247  46.873 1.00 29.96 ? 152 ALA C CB    1 
ATOM   962  N N     . LEU A 1 136 ? -36.662 -2.503  46.536 1.00 23.65 ? 153 LEU C N     1 
ATOM   963  C CA    . LEU A 1 136 ? -35.717 -1.523  47.069 1.00 25.38 ? 153 LEU C CA    1 
ATOM   964  C C     . LEU A 1 136 ? -35.632 -0.310  46.159 1.00 24.85 ? 153 LEU C C     1 
ATOM   965  O O     . LEU A 1 136 ? -35.688 0.836   46.618 1.00 23.50 ? 153 LEU C O     1 
ATOM   966  C CB    . LEU A 1 136 ? -34.334 -2.168  47.212 1.00 24.54 ? 153 LEU C CB    1 
ATOM   967  C CG    . LEU A 1 136 ? -33.234 -1.483  48.039 1.00 24.74 ? 153 LEU C CG    1 
ATOM   968  C CD1   . LEU A 1 136 ? -32.240 -2.531  48.489 1.00 22.15 ? 153 LEU C CD1   1 
ATOM   969  C CD2   . LEU A 1 136 ? -32.528 -0.376  47.273 1.00 25.52 ? 153 LEU C CD2   1 
ATOM   970  N N     . LEU A 1 137 ? -35.458 -0.555  44.854 1.00 23.66 ? 154 LEU C N     1 
ATOM   971  C CA    . LEU A 1 137 ? -35.358 0.538   43.896 1.00 26.46 ? 154 LEU C CA    1 
ATOM   972  C C     . LEU A 1 137 ? -36.627 1.380   43.893 1.00 25.41 ? 154 LEU C C     1 
ATOM   973  O O     . LEU A 1 137 ? -36.557 2.615   43.910 1.00 27.63 ? 154 LEU C O     1 
ATOM   974  C CB    . LEU A 1 137 ? -35.060 -0.019  42.501 1.00 27.19 ? 154 LEU C CB    1 
ATOM   975  C CG    . LEU A 1 137 ? -33.659 -0.625  42.388 1.00 28.93 ? 154 LEU C CG    1 
ATOM   976  C CD1   . LEU A 1 137 ? -33.441 -1.262  41.022 1.00 30.36 ? 154 LEU C CD1   1 
ATOM   977  C CD2   . LEU A 1 137 ? -32.590 0.441   42.673 1.00 27.04 ? 154 LEU C CD2   1 
ATOM   978  N N     . ASP A 1 138 ? -37.800 0.733   43.908 1.00 29.43 ? 155 ASP C N     1 
ATOM   979  C CA    . ASP A 1 138 ? -39.045 1.494   44.002 1.00 30.72 ? 155 ASP C CA    1 
ATOM   980  C C     . ASP A 1 138 ? -39.036 2.396   45.222 1.00 30.86 ? 155 ASP C C     1 
ATOM   981  O O     . ASP A 1 138 ? -39.413 3.571   45.144 1.00 30.31 ? 155 ASP C O     1 
ATOM   982  C CB    . ASP A 1 138 ? -40.258 0.560   44.057 1.00 34.79 ? 155 ASP C CB    1 
ATOM   983  C CG    . ASP A 1 138 ? -40.471 -0.207  42.770 1.00 41.31 ? 155 ASP C CG    1 
ATOM   984  O OD1   . ASP A 1 138 ? -39.944 0.226   41.725 1.00 42.60 ? 155 ASP C OD1   1 
ATOM   985  O OD2   . ASP A 1 138 ? -41.192 -1.232  42.796 1.00 42.96 ? 155 ASP C OD2   1 
ATOM   986  N N     . ARG A 1 139 ? -38.588 1.865   46.360 1.00 26.63 ? 156 ARG C N     1 
ATOM   987  C CA    . ARG A 1 139 ? -38.615 2.647   47.589 1.00 28.23 ? 156 ARG C CA    1 
ATOM   988  C C     . ARG A 1 139 ? -37.638 3.813   47.546 1.00 26.98 ? 156 ARG C C     1 
ATOM   989  O O     . ARG A 1 139 ? -37.941 4.903   48.044 1.00 29.40 ? 156 ARG C O     1 
ATOM   990  C CB    . ARG A 1 139 ? -38.347 1.727   48.779 1.00 28.73 ? 156 ARG C CB    1 
ATOM   991  C CG    . ARG A 1 139 ? -38.350 2.443   50.107 1.00 33.44 ? 156 ARG C CG    1 
ATOM   992  C CD    . ARG A 1 139 ? -37.771 1.575   51.191 1.00 34.10 ? 156 ARG C CD    1 
ATOM   993  N NE    . ARG A 1 139 ? -38.584 1.721   52.387 1.00 38.13 ? 156 ARG C NE    1 
ATOM   994  C CZ    . ARG A 1 139 ? -38.382 2.659   53.301 1.00 40.13 ? 156 ARG C CZ    1 
ATOM   995  N NH1   . ARG A 1 139 ? -37.263 3.362   53.329 1.00 46.76 ? 156 ARG C NH1   1 
ATOM   996  N NH2   . ARG A 1 139 ? -39.327 2.904   54.203 1.00 40.80 ? 156 ARG C NH2   1 
ATOM   997  N N     . TYR A 1 140 ? -36.463 3.615   46.949 1.00 27.41 ? 157 TYR C N     1 
ATOM   998  C CA    . TYR A 1 140 ? -35.503 4.710   46.891 1.00 25.87 ? 157 TYR C CA    1 
ATOM   999  C C     . TYR A 1 140 ? -35.967 5.801   45.922 1.00 25.23 ? 157 TYR C C     1 
ATOM   1000 O O     . TYR A 1 140 ? -35.790 6.993   46.194 1.00 28.13 ? 157 TYR C O     1 
ATOM   1001 C CB    . TYR A 1 140 ? -34.119 4.161   46.506 1.00 26.35 ? 157 TYR C CB    1 
ATOM   1002 C CG    . TYR A 1 140 ? -33.015 5.196   46.413 1.00 24.63 ? 157 TYR C CG    1 
ATOM   1003 C CD1   . TYR A 1 140 ? -32.781 5.885   45.233 1.00 27.79 ? 157 TYR C CD1   1 
ATOM   1004 C CD2   . TYR A 1 140 ? -32.199 5.469   47.504 1.00 25.12 ? 157 TYR C CD2   1 
ATOM   1005 C CE1   . TYR A 1 140 ? -31.764 6.828   45.145 1.00 28.17 ? 157 TYR C CE1   1 
ATOM   1006 C CE2   . TYR A 1 140 ? -31.182 6.395   47.423 1.00 23.12 ? 157 TYR C CE2   1 
ATOM   1007 C CZ    . TYR A 1 140 ? -30.967 7.075   46.246 1.00 25.11 ? 157 TYR C CZ    1 
ATOM   1008 O OH    . TYR A 1 140 ? -29.959 8.006   46.184 1.00 29.77 ? 157 TYR C OH    1 
ATOM   1009 N N     . PHE A 1 141 ? -36.597 5.422   44.811 1.00 29.51 ? 158 PHE C N     1 
ATOM   1010 C CA    . PHE A 1 141 ? -36.859 6.361   43.728 1.00 30.66 ? 158 PHE C CA    1 
ATOM   1011 C C     . PHE A 1 141 ? -38.270 6.939   43.731 1.00 38.15 ? 158 PHE C C     1 
ATOM   1012 O O     . PHE A 1 141 ? -38.541 7.856   42.950 1.00 43.33 ? 158 PHE C O     1 
ATOM   1013 C CB    . PHE A 1 141 ? -36.571 5.679   42.388 1.00 32.99 ? 158 PHE C CB    1 
ATOM   1014 C CG    . PHE A 1 141 ? -35.115 5.646   42.065 1.00 31.64 ? 158 PHE C CG    1 
ATOM   1015 C CD1   . PHE A 1 141 ? -34.412 6.825   41.873 1.00 32.28 ? 158 PHE C CD1   1 
ATOM   1016 C CD2   . PHE A 1 141 ? -34.430 4.444   42.044 1.00 30.62 ? 158 PHE C CD2   1 
ATOM   1017 C CE1   . PHE A 1 141 ? -33.062 6.799   41.610 1.00 31.62 ? 158 PHE C CE1   1 
ATOM   1018 C CE2   . PHE A 1 141 ? -33.082 4.413   41.795 1.00 31.24 ? 158 PHE C CE2   1 
ATOM   1019 C CZ    . PHE A 1 141 ? -32.394 5.593   41.571 1.00 32.69 ? 158 PHE C CZ    1 
ATOM   1020 N N     . GLU A 1 142 ? -39.160 6.455   44.590 1.00 40.76 ? 159 GLU C N     1 
ATOM   1021 C CA    . GLU A 1 142 ? -40.504 7.037   44.692 1.00 44.43 ? 159 GLU C CA    1 
ATOM   1022 C C     . GLU A 1 142 ? -40.703 7.777   46.010 1.00 46.24 ? 159 GLU C C     1 
ATOM   1023 O O     . GLU A 1 142 ? -39.838 8.534   46.451 1.00 54.18 ? 159 GLU C O     1 
ATOM   1024 C CB    . GLU A 1 142 ? -41.575 5.954   44.545 1.00 47.30 ? 159 GLU C CB    1 
ATOM   1025 C CG    . GLU A 1 142 ? -41.581 5.249   43.198 1.00 44.38 ? 159 GLU C CG    1 
ATOM   1026 C CD    . GLU A 1 142 ? -42.186 3.863   43.278 0.25 46.63 ? 159 GLU C CD    1 
ATOM   1027 O OE1   . GLU A 1 142 ? -42.617 3.468   44.381 0.46 48.48 ? 159 GLU C OE1   1 
ATOM   1028 O OE2   . GLU A 1 142 ? -42.244 3.175   42.236 0.46 50.39 ? 159 GLU C OE2   1 
ATOM   1029 N N     . GLY B 1 1   ? -18.413 14.578  60.409 1.00 48.85 ? 18  GLY A N     1 
ATOM   1030 C CA    . GLY B 1 1   ? -18.495 15.951  59.880 1.00 48.00 ? 18  GLY A CA    1 
ATOM   1031 C C     . GLY B 1 1   ? -18.469 16.983  60.992 1.00 46.50 ? 18  GLY A C     1 
ATOM   1032 O O     . GLY B 1 1   ? -18.176 16.611  62.138 1.00 48.49 ? 18  GLY A O     1 
ATOM   1033 N N     . MET B 1 2   ? -18.745 18.245  60.653 1.00 44.54 ? 19  MET A N     1 
ATOM   1034 C CA    . MET B 1 2   ? -18.779 19.362  61.636 1.00 41.71 ? 19  MET A CA    1 
ATOM   1035 C C     . MET B 1 2   ? -19.975 19.205  62.585 1.00 47.53 ? 19  MET A C     1 
ATOM   1036 O O     . MET B 1 2   ? -19.903 19.740  63.704 1.00 42.83 ? 19  MET A O     1 
ATOM   1037 C CB    . MET B 1 2   ? -18.826 20.729  60.946 1.00 44.74 ? 19  MET A CB    1 
ATOM   1038 N N     . ARG B 1 3   ? -21.055 18.572  62.110 1.00 48.08 ? 20  ARG A N     1 
ATOM   1039 C CA    . ARG B 1 3   ? -22.290 18.373  62.913 1.00 46.70 ? 20  ARG A CA    1 
ATOM   1040 C C     . ARG B 1 3   ? -22.575 16.880  63.126 1.00 37.13 ? 20  ARG A C     1 
ATOM   1041 O O     . ARG B 1 3   ? -22.471 16.098  62.172 1.00 35.77 ? 20  ARG A O     1 
ATOM   1042 C CB    . ARG B 1 3   ? -23.486 19.026  62.220 1.00 30.00 ? 20  ARG A CB    1 
ATOM   1043 C CG    . ARG B 1 3   ? -23.352 20.529  62.030 1.00 30.00 ? 20  ARG A CG    1 
ATOM   1044 C CD    . ARG B 1 3   ? -24.311 21.037  60.975 1.00 30.00 ? 20  ARG A CD    1 
ATOM   1045 N NE    . ARG B 1 3   ? -25.698 21.011  61.411 1.00 30.00 ? 20  ARG A NE    1 
ATOM   1046 C CZ    . ARG B 1 3   ? -26.143 21.528  62.547 1.00 30.00 ? 20  ARG A CZ    1 
ATOM   1047 N NH1   . ARG B 1 3   ? -25.306 22.119  63.380 1.00 30.00 ? 20  ARG A NH1   1 
ATOM   1048 N NH2   . ARG B 1 3   ? -27.425 21.455  62.843 1.00 30.00 ? 20  ARG A NH2   1 
ATOM   1049 N N     . PRO B 1 4   ? -22.954 16.464  64.349 1.00 34.24 ? 21  PRO A N     1 
ATOM   1050 C CA    . PRO B 1 4   ? -23.283 15.071  64.619 1.00 29.96 ? 21  PRO A CA    1 
ATOM   1051 C C     . PRO B 1 4   ? -24.545 14.623  63.872 1.00 30.90 ? 21  PRO A C     1 
ATOM   1052 O O     . PRO B 1 4   ? -25.404 15.440  63.626 1.00 31.62 ? 21  PRO A O     1 
ATOM   1053 C CB    . PRO B 1 4   ? -23.594 15.050  66.122 1.00 28.43 ? 21  PRO A CB    1 
ATOM   1054 C CG    . PRO B 1 4   ? -23.932 16.481  66.456 1.00 31.76 ? 21  PRO A CG    1 
ATOM   1055 C CD    . PRO B 1 4   ? -23.071 17.309  65.530 1.00 34.06 ? 21  PRO A CD    1 
ATOM   1056 N N     . ALA B 1 5   ? -24.600 13.343  63.503 1.00 26.49 ? 22  ALA A N     1 
ATOM   1057 C CA    . ALA B 1 5   ? -25.810 12.783  62.866 1.00 25.42 ? 22  ALA A CA    1 
ATOM   1058 C C     . ALA B 1 5   ? -26.640 12.198  64.009 1.00 23.52 ? 22  ALA A C     1 
ATOM   1059 O O     . ALA B 1 5   ? -26.100 11.385  64.759 1.00 24.92 ? 22  ALA A O     1 
ATOM   1060 C CB    . ALA B 1 5   ? -25.433 11.725  61.864 1.00 25.71 ? 22  ALA A CB    1 
ATOM   1061 N N     . LEU B 1 6   ? -27.893 12.624  64.132 1.00 21.62 ? 23  LEU A N     1 
ATOM   1062 C CA    . LEU B 1 6   ? -28.742 12.177  65.258 1.00 20.77 ? 23  LEU A CA    1 
ATOM   1063 C C     . LEU B 1 6   ? -29.837 11.243  64.750 1.00 24.12 ? 23  LEU A C     1 
ATOM   1064 O O     . LEU B 1 6   ? -30.407 11.508  63.693 1.00 26.75 ? 23  LEU A O     1 
ATOM   1065 C CB    . LEU B 1 6   ? -29.335 13.414  65.934 1.00 23.94 ? 23  LEU A CB    1 
ATOM   1066 C CG    . LEU B 1 6   ? -28.315 14.491  66.291 1.00 23.50 ? 23  LEU A CG    1 
ATOM   1067 C CD1   . LEU B 1 6   ? -28.995 15.730  66.841 1.00 24.60 ? 23  LEU A CD1   1 
ATOM   1068 C CD2   . LEU B 1 6   ? -27.303 13.959  67.283 1.00 24.29 ? 23  LEU A CD2   1 
ATOM   1069 N N     . TYR B 1 7   ? -30.083 10.179  65.503 1.00 18.56 ? 24  TYR A N     1 
ATOM   1070 C CA    . TYR B 1 7   ? -31.132 9.205   65.161 1.00 17.44 ? 24  TYR A CA    1 
ATOM   1071 C C     . TYR B 1 7   ? -32.177 9.288   66.244 1.00 20.80 ? 24  TYR A C     1 
ATOM   1072 O O     . TYR B 1 7   ? -31.857 9.061   67.407 1.00 23.28 ? 24  TYR A O     1 
ATOM   1073 C CB    . TYR B 1 7   ? -30.495 7.818   65.096 1.00 19.28 ? 24  TYR A CB    1 
ATOM   1074 C CG    . TYR B 1 7   ? -31.412 6.708   64.615 1.00 25.12 ? 24  TYR A CG    1 
ATOM   1075 C CD1   . TYR B 1 7   ? -32.411 6.203   65.432 1.00 26.71 ? 24  TYR A CD1   1 
ATOM   1076 C CD2   . TYR B 1 7   ? -31.272 6.169   63.346 1.00 29.71 ? 24  TYR A CD2   1 
ATOM   1077 C CE1   . TYR B 1 7   ? -33.254 5.199   64.998 1.00 29.52 ? 24  TYR A CE1   1 
ATOM   1078 C CE2   . TYR B 1 7   ? -32.101 5.156   62.903 1.00 32.98 ? 24  TYR A CE2   1 
ATOM   1079 C CZ    . TYR B 1 7   ? -33.093 4.673   63.732 1.00 33.20 ? 24  TYR A CZ    1 
ATOM   1080 O OH    . TYR B 1 7   ? -33.921 3.688   63.304 1.00 35.08 ? 24  TYR A OH    1 
ATOM   1081 N N     . PHE B 1 8   ? -33.401 9.598   65.847 1.00 20.85 ? 25  PHE A N     1 
ATOM   1082 C CA    . PHE B 1 8   ? -34.517 9.687   66.813 1.00 20.97 ? 25  PHE A CA    1 
ATOM   1083 C C     . PHE B 1 8   ? -35.374 8.442   66.712 1.00 21.81 ? 25  PHE A C     1 
ATOM   1084 O O     . PHE B 1 8   ? -35.767 8.047   65.613 1.00 22.48 ? 25  PHE A O     1 
ATOM   1085 C CB    . PHE B 1 8   ? -35.410 10.908  66.590 1.00 19.12 ? 25  PHE A CB    1 
ATOM   1086 C CG    . PHE B 1 8   ? -36.568 10.936  67.571 1.00 21.23 ? 25  PHE A CG    1 
ATOM   1087 C CD1   . PHE B 1 8   ? -36.343 11.136  68.924 1.00 17.70 ? 25  PHE A CD1   1 
ATOM   1088 C CD2   . PHE B 1 8   ? -37.869 10.713  67.144 1.00 22.27 ? 25  PHE A CD2   1 
ATOM   1089 C CE1   . PHE B 1 8   ? -37.395 11.138  69.820 1.00 21.58 ? 25  PHE A CE1   1 
ATOM   1090 C CE2   . PHE B 1 8   ? -38.914 10.718  68.048 1.00 24.14 ? 25  PHE A CE2   1 
ATOM   1091 C CZ    . PHE B 1 8   ? -38.676 10.929  69.379 1.00 20.04 ? 25  PHE A CZ    1 
ATOM   1092 N N     . CYS B 1 9   ? -35.657 7.853   67.866 1.00 22.70 ? 26  CYS A N     1 
ATOM   1093 C CA    . CYS B 1 9   ? -36.552 6.680   67.914 1.00 20.84 ? 26  CYS A CA    1 
ATOM   1094 C C     . CYS B 1 9   ? -37.792 7.014   68.742 1.00 21.85 ? 26  CYS A C     1 
ATOM   1095 O O     . CYS B 1 9   ? -37.637 7.539   69.855 1.00 21.51 ? 26  CYS A O     1 
ATOM   1096 C CB    . CYS B 1 9   ? -35.962 5.485   68.647 1.00 22.31 ? 26  CYS A CB    1 
ATOM   1097 S SG    . CYS B 1 9   ? -34.203 5.202   68.360 1.00 27.81 ? 26  CYS A SG    1 
ATOM   1098 N N     . GLY B 1 10  ? -38.953 6.718   68.196 1.00 19.15 ? 27  GLY A N     1 
ATOM   1099 C CA    . GLY B 1 10  ? -40.204 6.876   68.916 1.00 18.77 ? 27  GLY A CA    1 
ATOM   1100 C C     . GLY B 1 10  ? -41.216 5.912   68.348 1.00 18.52 ? 27  GLY A C     1 
ATOM   1101 O O     . GLY B 1 10  ? -41.111 5.476   67.193 1.00 20.23 ? 27  GLY A O     1 
ATOM   1102 N N     . SER B 1 11  ? -42.213 5.592   69.171 1.00 18.69 ? 28  SER A N     1 
ATOM   1103 C CA    . SER B 1 11  ? -43.183 4.570   68.804 1.00 21.10 ? 28  SER A CA    1 
ATOM   1104 C C     . SER B 1 11  ? -43.933 4.956   67.532 1.00 22.90 ? 28  SER A C     1 
ATOM   1105 O O     . SER B 1 11  ? -44.287 6.126   67.312 1.00 19.79 ? 28  SER A O     1 
ATOM   1106 C CB    . SER B 1 11  ? -44.173 4.346   69.954 1.00 19.88 ? 28  SER A CB    1 
ATOM   1107 O OG    . SER B 1 11  ? -45.227 3.485   69.552 1.00 22.68 ? 28  SER A OG    1 
ATOM   1108 N N     . ILE B 1 12  ? -44.145 3.963   66.676 1.00 20.57 ? 29  ILE A N     1 
ATOM   1109 C CA    . ILE B 1 12  ? -44.975 4.118   65.488 1.00 21.98 ? 29  ILE A CA    1 
ATOM   1110 C C     . ILE B 1 12  ? -46.111 3.105   65.557 1.00 23.78 ? 29  ILE A C     1 
ATOM   1111 O O     . ILE B 1 12  ? -47.264 3.477   65.798 1.00 23.62 ? 29  ILE A O     1 
ATOM   1112 C CB    . ILE B 1 12  ? -44.151 3.977   64.193 1.00 21.55 ? 29  ILE A CB    1 
ATOM   1113 C CG1   . ILE B 1 12  ? -43.074 5.069   64.139 1.00 23.49 ? 29  ILE A CG1   1 
ATOM   1114 C CG2   . ILE B 1 12  ? -45.038 4.070   62.980 1.00 22.72 ? 29  ILE A CG2   1 
ATOM   1115 C CD1   . ILE B 1 12  ? -42.309 5.123   62.808 1.00 20.27 ? 29  ILE A CD1   1 
ATOM   1116 N N     . ARG B 1 13  ? -45.806 1.824   65.353 1.00 19.77 ? 30  ARG A N     1 
ATOM   1117 C CA    . ARG B 1 13  ? -46.839 0.799   65.467 1.00 20.24 ? 30  ARG A CA    1 
ATOM   1118 C C     . ARG B 1 13  ? -47.131 0.447   66.922 1.00 22.42 ? 30  ARG A C     1 
ATOM   1119 O O     . ARG B 1 13  ? -48.159 -0.174  67.210 1.00 24.04 ? 30  ARG A O     1 
ATOM   1120 C CB    . ARG B 1 13  ? -46.426 -0.441  64.665 1.00 22.36 ? 30  ARG A CB    1 
ATOM   1121 C CG    . ARG B 1 13  ? -46.674 -0.253  63.161 1.00 25.29 ? 30  ARG A CG    1 
ATOM   1122 C CD    . ARG B 1 13  ? -46.174 -1.430  62.323 1.00 22.38 ? 30  ARG A CD    1 
ATOM   1123 N NE    . ARG B 1 13  ? -46.099 -1.071  60.906 0.97 23.05 ? 30  ARG A NE    1 
ATOM   1124 C CZ    . ARG B 1 13  ? -45.481 -1.808  59.990 0.78 24.55 ? 30  ARG A CZ    1 
ATOM   1125 N NH1   . ARG B 1 13  ? -44.969 -2.987  60.288 1.00 21.43 ? 30  ARG A NH1   1 
ATOM   1126 N NH2   . ARG B 1 13  ? -45.367 -1.346  58.745 0.95 26.76 ? 30  ARG A NH2   1 
ATOM   1127 N N     . GLY B 1 14  ? -46.258 0.833   67.852 1.00 20.45 ? 31  GLY A N     1 
ATOM   1128 C CA    . GLY B 1 14  ? -46.632 0.730   69.254 1.00 20.56 ? 31  GLY A CA    1 
ATOM   1129 C C     . GLY B 1 14  ? -47.729 1.690   69.663 1.00 27.07 ? 31  GLY A C     1 
ATOM   1130 O O     . GLY B 1 14  ? -48.330 1.509   70.728 1.00 28.02 ? 31  GLY A O     1 
ATOM   1131 N N     . GLY B 1 15  ? -48.021 2.677   68.828 1.00 23.41 ? 32  GLY A N     1 
ATOM   1132 C CA    . GLY B 1 15  ? -48.968 3.719   69.166 1.00 24.50 ? 32  GLY A CA    1 
ATOM   1133 C C     . GLY B 1 15  ? -48.363 5.073   68.873 1.00 26.71 ? 32  GLY A C     1 
ATOM   1134 O O     . GLY B 1 15  ? -47.160 5.266   69.088 1.00 22.73 ? 32  GLY A O     1 
ATOM   1135 N N     . ARG B 1 16  ? -49.182 5.995   68.357 1.00 26.47 ? 33  ARG A N     1 
ATOM   1136 C CA    . ARG B 1 16  ? -48.714 7.353   67.965 1.00 28.55 ? 33  ARG A CA    1 
ATOM   1137 C C     . ARG B 1 16  ? -49.241 8.413   68.938 1.00 29.19 ? 33  ARG A C     1 
ATOM   1138 O O     . ARG B 1 16  ? -49.323 9.573   68.538 1.00 26.27 ? 33  ARG A O     1 
ATOM   1139 C CB    . ARG B 1 16  ? -49.191 7.698   66.552 1.00 29.17 ? 33  ARG A CB    1 
ATOM   1140 C CG    . ARG B 1 16  ? -48.834 6.669   65.490 1.00 35.02 ? 33  ARG A CG    1 
ATOM   1141 C CD    . ARG B 1 16  ? -47.423 6.793   64.958 1.00 36.07 ? 33  ARG A CD    1 
ATOM   1142 N NE    . ARG B 1 16  ? -47.047 8.118   64.494 1.00 40.86 ? 33  ARG A NE    1 
ATOM   1143 C CZ    . ARG B 1 16  ? -45.979 8.790   64.913 1.00 44.77 ? 33  ARG A CZ    1 
ATOM   1144 N NH1   . ARG B 1 16  ? -45.169 8.261   65.812 1.00 36.68 ? 33  ARG A NH1   1 
ATOM   1145 N NH2   . ARG B 1 16  ? -45.722 9.991   64.430 1.00 44.81 ? 33  ARG A NH2   1 
ATOM   1146 N N     . GLU B 1 17  ? -49.456 8.045   70.199 1.00 26.48 ? 34  GLU A N     1 
ATOM   1147 C CA    . GLU B 1 17  ? -50.003 8.978   71.218 1.00 28.07 ? 34  GLU A CA    1 
ATOM   1148 C C     . GLU B 1 17  ? -49.079 10.190  71.422 1.00 31.23 ? 34  GLU A C     1 
ATOM   1149 O O     . GLU B 1 17  ? -49.602 11.287  71.660 1.00 26.80 ? 34  GLU A O     1 
ATOM   1150 C CB    . GLU B 1 17  ? -50.195 8.239   72.543 1.00 33.07 ? 34  GLU A CB    1 
ATOM   1151 C CG    . GLU B 1 17  ? -51.376 7.286   72.547 1.00 40.70 ? 34  GLU A CG    1 
ATOM   1152 C CD    . GLU B 1 17  ? -51.066 5.876   72.079 1.00 39.80 ? 34  GLU A CD    1 
ATOM   1153 O OE1   . GLU B 1 17  ? -51.924 4.997   72.235 1.00 39.54 ? 34  GLU A OE1   1 
ATOM   1154 O OE2   . GLU B 1 17  ? -49.965 5.664   71.581 1.00 35.30 ? 34  GLU A OE2   1 
ATOM   1155 N N     . ASP B 1 18  ? -47.760 9.991   71.350 1.00 27.90 ? 35  ASP A N     1 
ATOM   1156 C CA    . ASP B 1 18  ? -46.770 11.065  71.635 1.00 27.89 ? 35  ASP A CA    1 
ATOM   1157 C C     . ASP B 1 18  ? -46.238 11.717  70.353 1.00 25.88 ? 35  ASP A C     1 
ATOM   1158 O O     . ASP B 1 18  ? -45.187 12.347  70.431 1.00 24.54 ? 35  ASP A O     1 
ATOM   1159 C CB    . ASP B 1 18  ? -45.618 10.536  72.494 1.00 25.19 ? 35  ASP A CB    1 
ATOM   1160 C CG    . ASP B 1 18  ? -46.040 10.112  73.889 1.00 31.37 ? 35  ASP A CG    1 
ATOM   1161 O OD1   . ASP B 1 18  ? -45.336 9.288   74.490 1.00 29.61 ? 35  ASP A OD1   1 
ATOM   1162 O OD2   . ASP B 1 18  ? -47.067 10.614  74.359 1.00 40.12 ? 35  ASP A OD2   1 
ATOM   1163 N N     . ARG B 1 19  ? -46.961 11.617  69.239 1.00 24.90 ? 36  ARG A N     1 
ATOM   1164 C CA    . ARG B 1 19  ? -46.450 12.134  67.940 1.00 27.80 ? 36  ARG A CA    1 
ATOM   1165 C C     . ARG B 1 19  ? -46.124 13.633  67.997 1.00 30.45 ? 36  ARG A C     1 
ATOM   1166 O O     . ARG B 1 19  ? -45.095 14.007  67.440 1.00 30.61 ? 36  ARG A O     1 
ATOM   1167 C CB    . ARG B 1 19  ? -47.467 11.871  66.826 1.00 29.40 ? 36  ARG A CB    1 
ATOM   1168 N N     . THR B 1 20  ? -46.963 14.465  68.614 1.00 30.76 ? 37  THR A N     1 
ATOM   1169 C CA    . THR B 1 20  ? -46.642 15.918  68.669 1.00 31.34 ? 37  THR A CA    1 
ATOM   1170 C C     . THR B 1 20  ? -45.370 16.141  69.497 1.00 27.01 ? 37  THR A C     1 
ATOM   1171 O O     . THR B 1 20  ? -44.574 17.005  69.130 1.00 28.23 ? 37  THR A O     1 
ATOM   1172 C CB    . THR B 1 20  ? -47.840 16.752  69.128 1.00 31.52 ? 37  THR A CB    1 
ATOM   1173 O OG1   . THR B 1 20  ? -47.980 16.534  70.529 1.00 38.73 ? 37  THR A OG1   1 
ATOM   1174 C CG2   . THR B 1 20  ? -49.115 16.378  68.409 1.00 31.88 ? 37  THR A CG2   1 
ATOM   1175 N N     . LEU B 1 21  ? -45.213 15.394  70.589 1.00 27.29 ? 38  LEU A N     1 
ATOM   1176 C CA    . LEU B 1 21  ? -44.010 15.497  71.453 1.00 25.72 ? 38  LEU A CA    1 
ATOM   1177 C C     . LEU B 1 21  ? -42.778 15.082  70.638 1.00 25.66 ? 38  LEU A C     1 
ATOM   1178 O O     . LEU B 1 21  ? -41.743 15.733  70.762 1.00 22.40 ? 38  LEU A O     1 
ATOM   1179 C CB    . LEU B 1 21  ? -44.202 14.591  72.667 1.00 27.54 ? 38  LEU A CB    1 
ATOM   1180 C CG    . LEU B 1 21  ? -42.965 14.422  73.539 1.00 29.39 ? 38  LEU A CG    1 
ATOM   1181 C CD1   . LEU B 1 21  ? -42.453 15.774  74.011 1.00 32.08 ? 38  LEU A CD1   1 
ATOM   1182 C CD2   . LEU B 1 21  ? -43.261 13.511  74.722 1.00 33.11 ? 38  LEU A CD2   1 
ATOM   1183 N N     . TYR B 1 22  ? -42.911 14.046  69.804 1.00 22.41 ? 39  TYR A N     1 
ATOM   1184 C CA    . TYR B 1 22  ? -41.788 13.602  68.937 1.00 22.34 ? 39  TYR A CA    1 
ATOM   1185 C C     . TYR B 1 22  ? -41.421 14.744  67.983 1.00 23.21 ? 39  TYR A C     1 
ATOM   1186 O O     . TYR B 1 22  ? -40.236 14.953  67.742 1.00 24.22 ? 39  TYR A O     1 
ATOM   1187 C CB    . TYR B 1 22  ? -42.152 12.350  68.136 1.00 23.23 ? 39  TYR A CB    1 
ATOM   1188 C CG    . TYR B 1 22  ? -42.492 11.125  68.945 1.00 21.22 ? 39  TYR A CG    1 
ATOM   1189 C CD1   . TYR B 1 22  ? -42.224 11.058  70.299 1.00 20.28 ? 39  TYR A CD1   1 
ATOM   1190 C CD2   . TYR B 1 22  ? -43.084 10.024  68.350 1.00 24.63 ? 39  TYR A CD2   1 
ATOM   1191 C CE1   . TYR B 1 22  ? -42.529 9.929   71.038 1.00 21.16 ? 39  TYR A CE1   1 
ATOM   1192 C CE2   . TYR B 1 22  ? -43.404 8.891   69.076 1.00 22.67 ? 39  TYR A CE2   1 
ATOM   1193 C CZ    . TYR B 1 22  ? -43.128 8.842   70.428 1.00 21.87 ? 39  TYR A CZ    1 
ATOM   1194 O OH    . TYR B 1 22  ? -43.437 7.729   71.151 1.00 22.25 ? 39  TYR A OH    1 
ATOM   1195 N N     . GLU B 1 23  ? -42.424 15.445  67.449 1.00 23.10 ? 40  GLU A N     1 
ATOM   1196 C CA    . GLU B 1 23  ? -42.169 16.596  66.547 1.00 25.08 ? 40  GLU A CA    1 
ATOM   1197 C C     . GLU B 1 23  ? -41.342 17.643  67.296 1.00 23.52 ? 40  GLU A C     1 
ATOM   1198 O O     . GLU B 1 23  ? -40.389 18.152  66.710 1.00 24.38 ? 40  GLU A O     1 
ATOM   1199 C CB    . GLU B 1 23  ? -43.482 17.209  66.072 1.00 31.07 ? 40  GLU A CB    1 
ATOM   1200 C CG    . GLU B 1 23  ? -44.228 16.338  65.085 1.00 36.63 ? 40  GLU A CG    1 
ATOM   1201 C CD    . GLU B 1 23  ? -45.454 17.017  64.503 1.00 49.20 ? 40  GLU A CD    1 
ATOM   1202 O OE1   . GLU B 1 23  ? -46.509 16.377  64.455 1.00 49.87 ? 40  GLU A OE1   1 
ATOM   1203 O OE2   . GLU B 1 23  ? -45.347 18.192  64.113 1.00 60.28 ? 40  GLU A OE2   1 
ATOM   1204 N N     . ARG B 1 24  ? -41.718 17.966  68.536 1.00 22.20 ? 41  ARG A N     1 
ATOM   1205 C CA    . ARG B 1 24  ? -40.929 18.932  69.299 1.00 23.69 ? 41  ARG A CA    1 
ATOM   1206 C C     . ARG B 1 24  ? -39.501 18.453  69.509 1.00 25.94 ? 41  ARG A C     1 
ATOM   1207 O O     . ARG B 1 24  ? -38.560 19.250  69.428 1.00 22.64 ? 41  ARG A O     1 
ATOM   1208 C CB    . ARG B 1 24  ? -41.580 19.223  70.649 1.00 25.68 ? 41  ARG A CB    1 
ATOM   1209 C CG    . ARG B 1 24  ? -42.789 20.128  70.580 1.00 24.08 ? 41  ARG A CG    1 
ATOM   1210 C CD    . ARG B 1 24  ? -43.512 20.140  71.931 1.00 26.25 ? 41  ARG A CD    1 
ATOM   1211 N NE    . ARG B 1 24  ? -42.690 20.654  73.021 1.00 25.70 ? 41  ARG A NE    1 
ATOM   1212 C CZ    . ARG B 1 24  ? -43.018 20.540  74.299 1.00 29.90 ? 41  ARG A CZ    1 
ATOM   1213 N NH1   . ARG B 1 24  ? -44.118 19.910  74.671 1.00 28.08 ? 41  ARG A NH1   1 
ATOM   1214 N NH2   . ARG B 1 24  ? -42.225 21.069  75.224 1.00 26.22 ? 41  ARG A NH2   1 
ATOM   1215 N N     . ILE B 1 25  ? -39.316 17.164  69.809 1.00 21.27 ? 42  ILE A N     1 
ATOM   1216 C CA    . ILE B 1 25  ? -37.961 16.646  69.994 1.00 19.85 ? 42  ILE A CA    1 
ATOM   1217 C C     . ILE B 1 25  ? -37.157 16.775  68.703 1.00 21.45 ? 42  ILE A C     1 
ATOM   1218 O O     . ILE B 1 25  ? -36.054 17.343  68.683 1.00 20.97 ? 42  ILE A O     1 
ATOM   1219 C CB    . ILE B 1 25  ? -38.001 15.190  70.496 1.00 19.20 ? 42  ILE A CB    1 
ATOM   1220 C CG1   . ILE B 1 25  ? -38.557 15.130  71.914 1.00 22.42 ? 42  ILE A CG1   1 
ATOM   1221 C CG2   . ILE B 1 25  ? -36.566 14.589  70.426 1.00 21.00 ? 42  ILE A CG2   1 
ATOM   1222 C CD1   . ILE B 1 25  ? -38.943 13.737  72.367 1.00 20.95 ? 42  ILE A CD1   1 
ATOM   1223 N N     . VAL B 1 26  ? -37.706 16.272  67.598 1.00 20.96 ? 43  VAL A N     1 
ATOM   1224 C CA    . VAL B 1 26  ? -36.958 16.257  66.346 1.00 21.12 ? 43  VAL A CA    1 
ATOM   1225 C C     . VAL B 1 26  ? -36.632 17.676  65.922 1.00 24.66 ? 43  VAL A C     1 
ATOM   1226 O O     . VAL B 1 26  ? -35.526 17.967  65.458 1.00 24.23 ? 43  VAL A O     1 
ATOM   1227 C CB    . VAL B 1 26  ? -37.757 15.508  65.269 1.00 20.28 ? 43  VAL A CB    1 
ATOM   1228 C CG1   . VAL B 1 26  ? -37.231 15.839  63.864 1.00 29.40 ? 43  VAL A CG1   1 
ATOM   1229 C CG2   . VAL B 1 26  ? -37.712 14.006  65.549 1.00 21.10 ? 43  VAL A CG2   1 
ATOM   1230 N N     . SER B 1 27  ? -37.589 18.584  66.107 1.00 24.75 ? 44  SER A N     1 
ATOM   1231 C CA    . SER B 1 27  ? -37.368 19.980  65.753 1.00 25.28 ? 44  SER A CA    1 
ATOM   1232 C C     . SER B 1 27  ? -36.206 20.565  66.548 1.00 23.64 ? 44  SER A C     1 
ATOM   1233 O O     . SER B 1 27  ? -35.335 21.237  65.976 1.00 25.09 ? 44  SER A O     1 
ATOM   1234 C CB    . SER B 1 27  ? -38.662 20.775  65.979 1.00 26.48 ? 44  SER A CB    1 
ATOM   1235 O OG    . SER B 1 27  ? -38.414 22.162  65.979 1.00 28.22 ? 44  SER A OG    1 
ATOM   1236 N N     . ARG B 1 28  ? -36.155 20.296  67.869 1.00 22.62 ? 45  ARG A N     1 
ATOM   1237 C CA    . ARG B 1 28  ? -35.059 20.806  68.691 1.00 21.35 ? 45  ARG A CA    1 
ATOM   1238 C C     . ARG B 1 28  ? -33.746 20.116  68.357 1.00 19.05 ? 45  ARG A C     1 
ATOM   1239 O O     . ARG B 1 28  ? -32.676 20.737  68.432 1.00 20.32 ? 45  ARG A O     1 
ATOM   1240 C CB    . ARG B 1 28  ? -35.363 20.620  70.188 1.00 20.09 ? 45  ARG A CB    1 
ATOM   1241 C CG    . ARG B 1 28  ? -34.428 21.434  71.098 1.00 22.26 ? 45  ARG A CG    1 
ATOM   1242 C CD    . ARG B 1 28  ? -34.345 22.938  70.660 1.00 25.54 ? 45  ARG A CD    1 
ATOM   1243 N NE    . ARG B 1 28  ? -33.817 23.791  71.725 1.00 23.09 ? 45  ARG A NE    1 
ATOM   1244 C CZ    . ARG B 1 28  ? -33.909 25.114  71.749 1.00 26.21 ? 45  ARG A CZ    1 
ATOM   1245 N NH1   . ARG B 1 28  ? -34.576 25.771  70.818 1.00 25.17 ? 45  ARG A NH1   1 
ATOM   1246 N NH2   . ARG B 1 28  ? -33.348 25.791  72.756 1.00 25.42 ? 45  ARG A NH2   1 
ATOM   1247 N N     . LEU B 1 29  ? -33.797 18.828  68.009 1.00 21.77 ? 46  LEU A N     1 
ATOM   1248 C CA    . LEU B 1 29  ? -32.570 18.110  67.689 1.00 21.32 ? 46  LEU A CA    1 
ATOM   1249 C C     . LEU B 1 29  ? -31.845 18.765  66.520 1.00 23.96 ? 46  LEU A C     1 
ATOM   1250 O O     . LEU B 1 29  ? -30.612 18.726  66.445 1.00 22.50 ? 46  LEU A O     1 
ATOM   1251 C CB    . LEU B 1 29  ? -32.899 16.659  67.362 1.00 22.01 ? 46  LEU A CB    1 
ATOM   1252 C CG    . LEU B 1 29  ? -33.270 15.784  68.566 1.00 20.10 ? 46  LEU A CG    1 
ATOM   1253 C CD1   . LEU B 1 29  ? -33.553 14.357  68.071 1.00 21.84 ? 46  LEU A CD1   1 
ATOM   1254 C CD2   . LEU B 1 29  ? -32.165 15.766  69.619 1.00 22.88 ? 46  LEU A CD2   1 
ATOM   1255 N N     . ARG B 1 30  ? -32.596 19.373  65.611 1.00 23.23 ? 47  ARG A N     1 
ATOM   1256 C CA    . ARG B 1 30  ? -31.992 20.021  64.452 1.00 27.46 ? 47  ARG A CA    1 
ATOM   1257 C C     . ARG B 1 30  ? -31.081 21.176  64.852 1.00 27.94 ? 47  ARG A C     1 
ATOM   1258 O O     . ARG B 1 30  ? -30.221 21.584  64.060 1.00 27.82 ? 47  ARG A O     1 
ATOM   1259 C CB    . ARG B 1 30  ? -33.101 20.473  63.503 1.00 24.99 ? 47  ARG A CB    1 
ATOM   1260 C CG    . ARG B 1 30  ? -33.683 19.311  62.730 1.00 31.51 ? 47  ARG A CG    1 
ATOM   1261 C CD    . ARG B 1 30  ? -34.705 19.711  61.681 1.00 35.25 ? 47  ARG A CD    1 
ATOM   1262 N NE    . ARG B 1 30  ? -36.068 19.563  62.167 1.00 46.41 ? 47  ARG A NE    1 
ATOM   1263 C CZ    . ARG B 1 30  ? -37.021 18.909  61.512 1.00 55.19 ? 47  ARG A CZ    1 
ATOM   1264 N NH1   . ARG B 1 30  ? -36.783 18.326  60.346 1.00 58.97 ? 47  ARG A NH1   1 
ATOM   1265 N NH2   . ARG B 1 30  ? -38.241 18.836  62.041 1.00 57.78 ? 47  ARG A NH2   1 
ATOM   1266 N N     . ARG B 1 31  ? -31.239 21.701  66.067 1.00 25.26 ? 48  ARG A N     1 
ATOM   1267 C CA    . ARG B 1 31  ? -30.317 22.722  66.560 1.00 26.24 ? 48  ARG A CA    1 
ATOM   1268 C C     . ARG B 1 31  ? -28.908 22.163  66.699 1.00 29.82 ? 48  ARG A C     1 
ATOM   1269 O O     . ARG B 1 31  ? -27.924 22.897  66.537 1.00 30.31 ? 48  ARG A O     1 
ATOM   1270 C CB    . ARG B 1 31  ? -30.842 23.274  67.898 1.00 27.90 ? 48  ARG A CB    1 
ATOM   1271 C CG    . ARG B 1 31  ? -29.858 24.087  68.756 1.00 30.08 ? 48  ARG A CG    1 
ATOM   1272 C CD    . ARG B 1 31  ? -30.601 24.811  69.917 1.00 30.85 ? 48  ARG A CD    1 
ATOM   1273 N NE    . ARG B 1 31  ? -29.805 25.916  70.445 1.00 34.12 ? 48  ARG A NE    1 
ATOM   1274 C CZ    . ARG B 1 31  ? -29.080 25.858  71.557 1.00 38.86 ? 48  ARG A CZ    1 
ATOM   1275 N NH1   . ARG B 1 31  ? -29.239 24.879  72.438 1.00 34.83 ? 48  ARG A NH1   1 
ATOM   1276 N NH2   . ARG B 1 31  ? -28.193 26.819  71.807 1.00 37.00 ? 48  ARG A NH2   1 
ATOM   1277 N N     . PHE B 1 32  ? -28.791 20.855  66.925 1.00 26.92 ? 49  PHE A N     1 
ATOM   1278 C CA    . PHE B 1 32  ? -27.523 20.258  67.307 1.00 28.19 ? 49  PHE A CA    1 
ATOM   1279 C C     . PHE B 1 32  ? -26.892 19.386  66.246 1.00 25.14 ? 49  PHE A C     1 
ATOM   1280 O O     . PHE B 1 32  ? -25.714 19.053  66.380 1.00 27.47 ? 49  PHE A O     1 
ATOM   1281 C CB    . PHE B 1 32  ? -27.706 19.410  68.567 1.00 28.08 ? 49  PHE A CB    1 
ATOM   1282 C CG    . PHE B 1 32  ? -28.405 20.123  69.658 1.00 27.59 ? 49  PHE A CG    1 
ATOM   1283 C CD1   . PHE B 1 32  ? -27.792 21.175  70.312 1.00 30.17 ? 49  PHE A CD1   1 
ATOM   1284 C CD2   . PHE B 1 32  ? -29.699 19.781  69.990 1.00 26.96 ? 49  PHE A CD2   1 
ATOM   1285 C CE1   . PHE B 1 32  ? -28.445 21.839  71.328 1.00 31.70 ? 49  PHE A CE1   1 
ATOM   1286 C CE2   . PHE B 1 32  ? -30.359 20.449  70.989 1.00 28.19 ? 49  PHE A CE2   1 
ATOM   1287 C CZ    . PHE B 1 32  ? -29.729 21.474  71.664 1.00 25.53 ? 49  PHE A CZ    1 
ATOM   1288 N N     . GLY B 1 33  ? -27.639 18.971  65.235 1.00 27.50 ? 50  GLY A N     1 
ATOM   1289 C CA    . GLY B 1 33  ? -27.070 18.098  64.233 1.00 31.66 ? 50  GLY A CA    1 
ATOM   1290 C C     . GLY B 1 33  ? -28.092 17.792  63.169 1.00 30.14 ? 50  GLY A C     1 
ATOM   1291 O O     . GLY B 1 33  ? -29.181 18.365  63.144 1.00 29.48 ? 50  GLY A O     1 
ATOM   1292 N N     . THR B 1 34  ? -27.722 16.877  62.281 1.00 23.67 ? 51  THR A N     1 
ATOM   1293 C CA    . THR B 1 34  ? -28.630 16.392  61.252 1.00 26.51 ? 51  THR A CA    1 
ATOM   1294 C C     . THR B 1 34  ? -29.409 15.201  61.779 1.00 28.53 ? 51  THR A C     1 
ATOM   1295 O O     . THR B 1 34  ? -28.815 14.243  62.285 1.00 31.08 ? 51  THR A O     1 
ATOM   1296 C CB    . THR B 1 34  ? -27.861 15.987  59.998 1.00 31.84 ? 51  THR A CB    1 
ATOM   1297 O OG1   . THR B 1 34  ? -26.794 16.919  59.774 1.00 37.17 ? 51  THR A OG1   1 
ATOM   1298 C CG2   . THR B 1 34  ? -28.793 15.941  58.796 1.00 36.32 ? 51  THR A CG2   1 
ATOM   1299 N N     . VAL B 1 35  ? -30.728 15.250  61.640 1.00 25.35 ? 52  VAL A N     1 
ATOM   1300 C CA    . VAL B 1 35  ? -31.599 14.188  62.123 1.00 30.53 ? 52  VAL A CA    1 
ATOM   1301 C C     . VAL B 1 35  ? -31.859 13.234  60.965 1.00 34.44 ? 52  VAL A C     1 
ATOM   1302 O O     . VAL B 1 35  ? -32.487 13.602  59.971 1.00 35.01 ? 52  VAL A O     1 
ATOM   1303 C CB    . VAL B 1 35  ? -32.908 14.741  62.693 1.00 30.59 ? 52  VAL A CB    1 
ATOM   1304 C CG1   . VAL B 1 35  ? -33.741 13.591  63.268 1.00 33.45 ? 52  VAL A CG1   1 
ATOM   1305 C CG2   . VAL B 1 35  ? -32.619 15.805  63.759 1.00 29.35 ? 52  VAL A CG2   1 
ATOM   1306 N N     . LEU B 1 36  ? -31.385 11.999  61.100 1.00 34.66 ? 53  LEU A N     1 
ATOM   1307 C CA    . LEU B 1 36  ? -31.558 11.029  60.025 1.00 40.83 ? 53  LEU A CA    1 
ATOM   1308 C C     . LEU B 1 36  ? -32.982 10.502  59.944 1.00 44.03 ? 53  LEU A C     1 
ATOM   1309 O O     . LEU B 1 36  ? -33.404 10.056  58.871 1.00 48.90 ? 53  LEU A O     1 
ATOM   1310 C CB    . LEU B 1 36  ? -30.577 9.874   60.209 1.00 35.85 ? 53  LEU A CB    1 
ATOM   1311 C CG    . LEU B 1 36  ? -29.116 10.320  60.243 1.00 32.93 ? 53  LEU A CG    1 
ATOM   1312 C CD1   . LEU B 1 36  ? -28.284 9.382   61.115 1.00 32.07 ? 53  LEU A CD1   1 
ATOM   1313 C CD2   . LEU B 1 36  ? -28.545 10.395  58.838 1.00 35.59 ? 53  LEU A CD2   1 
ATOM   1314 N N     . THR B 1 37  ? -33.738 10.577  61.037 1.00 44.39 ? 54  THR A N     1 
ATOM   1315 C CA    . THR B 1 37  ? -35.049 9.948   61.133 1.00 50.84 ? 54  THR A CA    1 
ATOM   1316 C C     . THR B 1 37  ? -36.173 10.947  61.407 1.00 56.69 ? 54  THR A C     1 
ATOM   1317 O O     . THR B 1 37  ? -36.802 10.907  62.475 1.00 54.36 ? 54  THR A O     1 
ATOM   1318 C CB    . THR B 1 37  ? -35.019 8.894   62.241 1.00 56.39 ? 54  THR A CB    1 
ATOM   1319 O OG1   . THR B 1 37  ? -34.383 9.454   63.397 1.00 57.89 ? 54  THR A OG1   1 
ATOM   1320 C CG2   . THR B 1 37  ? -34.235 7.681   61.795 1.00 63.49 ? 54  THR A CG2   1 
ATOM   1321 N N     . GLU B 1 38  ? -36.447 11.842  60.452 1.00 54.34 ? 55  GLU A N     1 
ATOM   1322 C CA    . GLU B 1 38  ? -37.587 12.743  60.603 1.00 52.55 ? 55  GLU A CA    1 
ATOM   1323 C C     . GLU B 1 38  ? -38.922 12.012  60.493 1.00 55.71 ? 55  GLU A C     1 
ATOM   1324 O O     . GLU B 1 38  ? -39.950 12.565  60.906 1.00 51.19 ? 55  GLU A O     1 
ATOM   1325 C CB    . GLU B 1 38  ? -37.518 13.864  59.561 1.00 53.94 ? 55  GLU A CB    1 
ATOM   1326 N N     . HIS B 1 39  ? -38.919 10.771  59.987 1.00 54.83 ? 56  HIS A N     1 
ATOM   1327 C CA    . HIS B 1 39  ? -40.167 10.060  59.706 1.00 54.52 ? 56  HIS A CA    1 
ATOM   1328 C C     . HIS B 1 39  ? -40.996 9.825   60.969 1.00 53.58 ? 56  HIS A C     1 
ATOM   1329 O O     . HIS B 1 39  ? -42.227 9.955   60.938 1.00 55.48 ? 56  HIS A O     1 
ATOM   1330 C CB    . HIS B 1 39  ? -39.866 8.729   59.014 1.00 46.44 ? 56  HIS A CB    1 
ATOM   1331 N N     . ALA B 1 53  ? -44.030 -7.584  54.811 1.00 49.33 ? 70  ALA A N     1 
ATOM   1332 C CA    . ALA B 1 53  ? -42.723 -8.072  55.245 1.00 39.83 ? 70  ALA A CA    1 
ATOM   1333 C C     . ALA B 1 53  ? -41.626 -7.541  54.326 1.00 38.09 ? 70  ALA A C     1 
ATOM   1334 O O     . ALA B 1 53  ? -40.599 -7.045  54.793 1.00 33.57 ? 70  ALA A O     1 
ATOM   1335 C CB    . ALA B 1 53  ? -42.703 -9.594  55.281 1.00 41.54 ? 70  ALA A CB    1 
ATOM   1336 N N     . GLY B 1 54  ? -41.847 -7.651  53.012 1.00 39.51 ? 71  GLY A N     1 
ATOM   1337 C CA    . GLY B 1 54  ? -40.890 -7.091  52.071 1.00 36.08 ? 71  GLY A CA    1 
ATOM   1338 C C     . GLY B 1 54  ? -40.691 -5.605  52.282 1.00 32.42 ? 71  GLY A C     1 
ATOM   1339 O O     . GLY B 1 54  ? -39.560 -5.116  52.331 1.00 33.15 ? 71  GLY A O     1 
ATOM   1340 N N     . GLY B 1 55  ? -41.795 -4.863  52.411 1.00 32.30 ? 72  GLY A N     1 
ATOM   1341 C CA    . GLY B 1 55  ? -41.686 -3.467  52.801 1.00 27.46 ? 72  GLY A CA    1 
ATOM   1342 C C     . GLY B 1 55  ? -41.028 -3.311  54.159 1.00 27.28 ? 72  GLY A C     1 
ATOM   1343 O O     . GLY B 1 55  ? -40.179 -2.441  54.357 1.00 24.15 ? 72  GLY A O     1 
ATOM   1344 N N     . ASP B 1 56  ? -41.393 -4.167  55.114 1.00 23.90 ? 73  ASP A N     1 
ATOM   1345 C CA    . ASP B 1 56  ? -40.799 -4.024  56.437 1.00 22.26 ? 73  ASP A CA    1 
ATOM   1346 C C     . ASP B 1 56  ? -39.317 -4.371  56.418 1.00 18.94 ? 73  ASP A C     1 
ATOM   1347 O O     . ASP B 1 56  ? -38.533 -3.791  57.182 1.00 20.36 ? 73  ASP A O     1 
ATOM   1348 C CB    . ASP B 1 56  ? -41.551 -4.898  57.430 1.00 22.89 ? 73  ASP A CB    1 
ATOM   1349 C CG    . ASP B 1 56  ? -42.922 -4.308  57.810 1.00 27.03 ? 73  ASP A CG    1 
ATOM   1350 O OD1   . ASP B 1 56  ? -43.285 -3.192  57.335 1.00 24.22 ? 73  ASP A OD1   1 
ATOM   1351 O OD2   . ASP B 1 56  ? -43.638 -4.976  58.583 1.00 28.04 ? 73  ASP A OD2   1 
ATOM   1352 N N     . ARG B 1 57  ? -38.914 -5.318  55.564 1.00 18.89 ? 74  ARG A N     1 
ATOM   1353 C CA    . ARG B 1 57  ? -37.494 -5.613  55.427 1.00 20.57 ? 74  ARG A CA    1 
ATOM   1354 C C     . ARG B 1 57  ? -36.720 -4.379  54.985 1.00 18.42 ? 74  ARG A C     1 
ATOM   1355 O O     . ARG B 1 57  ? -35.580 -4.171  55.403 1.00 21.96 ? 74  ARG A O     1 
ATOM   1356 C CB    . ARG B 1 57  ? -37.278 -6.745  54.423 1.00 24.46 ? 74  ARG A CB    1 
ATOM   1357 C CG    . ARG B 1 57  ? -37.455 -8.131  55.005 1.00 29.78 ? 74  ARG A CG    1 
ATOM   1358 C CD    . ARG B 1 57  ? -37.483 -9.127  53.882 1.00 34.02 ? 74  ARG A CD    1 
ATOM   1359 N NE    . ARG B 1 57  ? -36.147 -9.310  53.329 1.00 40.82 ? 74  ARG A NE    1 
ATOM   1360 C CZ    . ARG B 1 57  ? -35.826 -10.249 52.448 1.00 47.35 ? 74  ARG A CZ    1 
ATOM   1361 N NH1   . ARG B 1 57  ? -36.731 -11.096 51.980 1.00 51.04 ? 74  ARG A NH1   1 
ATOM   1362 N NH2   . ARG B 1 57  ? -34.570 -10.332 52.016 1.00 39.32 ? 74  ARG A NH2   1 
ATOM   1363 N N     . LEU B 1 58  ? -37.323 -3.551  54.139 1.00 20.75 ? 75  LEU A N     1 
ATOM   1364 C CA    . LEU B 1 58  ? -36.615 -2.363  53.669 1.00 18.52 ? 75  LEU A CA    1 
ATOM   1365 C C     . LEU B 1 58  ? -36.589 -1.282  54.733 1.00 22.51 ? 75  LEU A C     1 
ATOM   1366 O O     . LEU B 1 58  ? -35.598 -0.550  54.844 1.00 18.99 ? 75  LEU A O     1 
ATOM   1367 C CB    . LEU B 1 58  ? -37.272 -1.830  52.403 1.00 24.85 ? 75  LEU A CB    1 
ATOM   1368 C CG    . LEU B 1 58  ? -37.189 -2.778  51.210 1.00 24.97 ? 75  LEU A CG    1 
ATOM   1369 C CD1   . LEU B 1 58  ? -37.990 -2.218  50.058 1.00 24.29 ? 75  LEU A CD1   1 
ATOM   1370 C CD2   . LEU B 1 58  ? -35.739 -3.011  50.809 1.00 24.84 ? 75  LEU A CD2   1 
ATOM   1371 N N     . ILE B 1 59  ? -37.654 -1.184  55.536 1.00 19.27 ? 76  ILE A N     1 
ATOM   1372 C CA    . ILE B 1 59  ? -37.637 -0.255  56.660 1.00 21.25 ? 76  ILE A CA    1 
ATOM   1373 C C     . ILE B 1 59  ? -36.531 -0.641  57.625 1.00 19.98 ? 76  ILE A C     1 
ATOM   1374 O O     . ILE B 1 59  ? -35.766 0.208   58.095 1.00 21.35 ? 76  ILE A O     1 
ATOM   1375 C CB    . ILE B 1 59  ? -39.007 -0.236  57.361 1.00 19.38 ? 76  ILE A CB    1 
ATOM   1376 C CG1   . ILE B 1 59  ? -40.067 0.362   56.445 1.00 23.61 ? 76  ILE A CG1   1 
ATOM   1377 C CG2   . ILE B 1 59  ? -38.927 0.591   58.636 1.00 24.36 ? 76  ILE A CG2   1 
ATOM   1378 C CD1   . ILE B 1 59  ? -41.480 0.108   56.955 1.00 23.68 ? 76  ILE A CD1   1 
ATOM   1379 N N     . HIS B 1 60  ? -36.422 -1.937  57.915 1.00 19.25 ? 77  HIS A N     1 
ATOM   1380 C CA    . HIS B 1 60  ? -35.391 -2.432  58.817 1.00 18.10 ? 77  HIS A CA    1 
ATOM   1381 C C     . HIS B 1 60  ? -34.000 -2.069  58.302 1.00 20.46 ? 77  HIS A C     1 
ATOM   1382 O O     . HIS B 1 60  ? -33.176 -1.522  59.042 1.00 21.60 ? 77  HIS A O     1 
ATOM   1383 C CB    . HIS B 1 60  ? -35.537 -3.944  58.986 1.00 18.20 ? 77  HIS A CB    1 
ATOM   1384 C CG    . HIS B 1 60  ? -34.511 -4.548  59.887 1.00 20.32 ? 77  HIS A CG    1 
ATOM   1385 N ND1   . HIS B 1 60  ? -33.297 -5.008  59.426 1.00 20.64 ? 77  HIS A ND1   1 
ATOM   1386 C CD2   . HIS B 1 60  ? -34.529 -4.800  61.216 1.00 20.78 ? 77  HIS A CD2   1 
ATOM   1387 C CE1   . HIS B 1 60  ? -32.590 -5.471  60.442 1.00 20.05 ? 77  HIS A CE1   1 
ATOM   1388 N NE2   . HIS B 1 60  ? -33.323 -5.371  61.538 1.00 21.96 ? 77  HIS A NE2   1 
ATOM   1389 N N     . GLU B 1 61  ? -33.729 -2.347  57.019 1.00 20.26 ? 78  GLU A N     1 
ATOM   1390 C CA    . GLU B 1 61  ? -32.401 -2.071  56.465 1.00 19.33 ? 78  GLU A CA    1 
ATOM   1391 C C     . GLU B 1 61  ? -32.086 -0.573  56.471 1.00 19.97 ? 78  GLU A C     1 
ATOM   1392 O O     . GLU B 1 61  ? -30.986 -0.159  56.850 1.00 22.66 ? 78  GLU A O     1 
ATOM   1393 C CB    . GLU B 1 61  ? -32.298 -2.640  55.050 1.00 22.60 ? 78  GLU A CB    1 
ATOM   1394 C CG    . GLU B 1 61  ? -30.954 -2.308  54.323 1.00 22.15 ? 78  GLU A CG    1 
ATOM   1395 C CD    . GLU B 1 61  ? -29.684 -2.754  55.079 1.00 26.15 ? 78  GLU A CD    1 
ATOM   1396 O OE1   . GLU B 1 61  ? -29.759 -3.556  56.048 1.00 25.57 ? 78  GLU A OE1   1 
ATOM   1397 O OE2   . GLU B 1 61  ? -28.585 -2.296  54.696 1.00 27.37 ? 78  GLU A OE2   1 
ATOM   1398 N N     . GLN B 1 62  ? -33.037 0.259   56.053 1.00 21.39 ? 79  GLN A N     1 
ATOM   1399 C CA    . GLN B 1 62  ? -32.809 1.702   56.059 1.00 21.31 ? 79  GLN A CA    1 
ATOM   1400 C C     . GLN B 1 62  ? -32.462 2.206   57.445 1.00 24.59 ? 79  GLN A C     1 
ATOM   1401 O O     . GLN B 1 62  ? -31.561 3.034   57.608 1.00 23.82 ? 79  GLN A O     1 
ATOM   1402 C CB    . GLN B 1 62  ? -34.037 2.441   55.558 1.00 27.25 ? 79  GLN A CB    1 
ATOM   1403 C CG    . GLN B 1 62  ? -33.777 3.923   55.397 1.00 33.11 ? 79  GLN A CG    1 
ATOM   1404 C CD    . GLN B 1 62  ? -34.844 4.604   54.583 1.00 41.08 ? 79  GLN A CD    1 
ATOM   1405 O OE1   . GLN B 1 62  ? -36.031 4.536   54.923 1.00 44.79 ? 79  GLN A OE1   1 
ATOM   1406 N NE2   . GLN B 1 62  ? -34.440 5.271   53.510 1.00 40.05 ? 79  GLN A NE2   1 
ATOM   1407 N N     . ASN B 1 63  ? -33.211 1.750   58.453 1.00 19.77 ? 80  ASN A N     1 
ATOM   1408 C CA    . ASN B 1 63  ? -33.000 2.238   59.809 1.00 24.16 ? 80  ASN A CA    1 
ATOM   1409 C C     . ASN B 1 63  ? -31.712 1.686   60.401 1.00 22.33 ? 80  ASN A C     1 
ATOM   1410 O O     . ASN B 1 63  ? -31.020 2.384   61.150 1.00 21.68 ? 80  ASN A O     1 
ATOM   1411 C CB    . ASN B 1 63  ? -34.197 1.873   60.683 1.00 23.03 ? 80  ASN A CB    1 
ATOM   1412 C CG    . ASN B 1 63  ? -35.371 2.806   60.464 1.00 30.86 ? 80  ASN A CG    1 
ATOM   1413 O OD1   . ASN B 1 63  ? -35.203 4.015   60.307 1.00 34.90 ? 80  ASN A OD1   1 
ATOM   1414 N ND2   . ASN B 1 63  ? -36.567 2.249   60.470 1.00 32.43 ? 80  ASN A ND2   1 
ATOM   1415 N N     . LEU B 1 64  ? -31.361 0.439   60.074 1.00 19.66 ? 81  LEU A N     1 
ATOM   1416 C CA    . LEU B 1 64  ? -30.077 -0.082  60.540 1.00 18.53 ? 81  LEU A CA    1 
ATOM   1417 C C     . LEU B 1 64  ? -28.920 0.693   59.946 1.00 19.87 ? 81  LEU A C     1 
ATOM   1418 O O     . LEU B 1 64  ? -27.918 0.933   60.623 1.00 22.08 ? 81  LEU A O     1 
ATOM   1419 C CB    . LEU B 1 64  ? -29.913 -1.565  60.207 1.00 23.67 ? 81  LEU A CB    1 
ATOM   1420 C CG    . LEU B 1 64  ? -30.198 -2.450  61.421 1.00 27.58 ? 81  LEU A CG    1 
ATOM   1421 C CD1   . LEU B 1 64  ? -28.981 -2.468  62.334 1.00 28.44 ? 81  LEU A CD1   1 
ATOM   1422 C CD2   . LEU B 1 64  ? -31.440 -1.994  62.181 1.00 33.87 ? 81  LEU A CD2   1 
ATOM   1423 N N     . GLU B 1 65  ? -29.024 1.067   58.672 1.00 22.72 ? 82  GLU A N     1 
ATOM   1424 C CA    . GLU B 1 65  ? -27.949 1.860   58.086 1.00 25.20 ? 82  GLU A CA    1 
ATOM   1425 C C     . GLU B 1 65  ? -27.870 3.237   58.734 1.00 25.09 ? 82  GLU A C     1 
ATOM   1426 O O     . GLU B 1 65  ? -26.771 3.735   59.007 1.00 25.96 ? 82  GLU A O     1 
ATOM   1427 C CB    . GLU B 1 65  ? -28.131 1.965   56.577 1.00 21.24 ? 82  GLU A CB    1 
ATOM   1428 C CG    . GLU B 1 65  ? -28.008 0.617   55.879 1.00 25.47 ? 82  GLU A CG    1 
ATOM   1429 C CD    . GLU B 1 65  ? -26.585 0.071   55.881 1.00 30.90 ? 82  GLU A CD    1 
ATOM   1430 O OE1   . GLU B 1 65  ? -26.405 -1.114  55.513 1.00 32.66 ? 82  GLU A OE1   1 
ATOM   1431 O OE2   . GLU B 1 65  ? -25.641 0.815   56.245 1.00 31.59 ? 82  GLU A OE2   1 
ATOM   1432 N N     . TRP B 1 66  ? -29.018 3.860   59.011 1.00 24.36 ? 83  TRP A N     1 
ATOM   1433 C CA    . TRP B 1 66  ? -28.995 5.135   59.723 1.00 25.55 ? 83  TRP A CA    1 
ATOM   1434 C C     . TRP B 1 66  ? -28.437 4.969   61.124 1.00 23.42 ? 83  TRP A C     1 
ATOM   1435 O O     . TRP B 1 66  ? -27.663 5.803   61.594 1.00 25.76 ? 83  TRP A O     1 
ATOM   1436 C CB    . TRP B 1 66  ? -30.395 5.735   59.807 1.00 28.42 ? 83  TRP A CB    1 
ATOM   1437 C CG    . TRP B 1 66  ? -30.834 6.372   58.567 1.00 29.00 ? 83  TRP A CG    1 
ATOM   1438 C CD1   . TRP B 1 66  ? -30.044 6.875   57.573 1.00 30.58 ? 83  TRP A CD1   1 
ATOM   1439 C CD2   . TRP B 1 66  ? -32.183 6.572   58.153 1.00 29.82 ? 83  TRP A CD2   1 
ATOM   1440 N NE1   . TRP B 1 66  ? -30.830 7.377   56.556 1.00 32.04 ? 83  TRP A NE1   1 
ATOM   1441 C CE2   . TRP B 1 66  ? -32.147 7.206   56.893 1.00 33.92 ? 83  TRP A CE2   1 
ATOM   1442 C CE3   . TRP B 1 66  ? -33.423 6.284   58.729 1.00 34.45 ? 83  TRP A CE3   1 
ATOM   1443 C CZ2   . TRP B 1 66  ? -33.305 7.556   56.203 1.00 34.50 ? 83  TRP A CZ2   1 
ATOM   1444 C CZ3   . TRP B 1 66  ? -34.574 6.629   58.040 1.00 37.11 ? 83  TRP A CZ3   1 
ATOM   1445 C CH2   . TRP B 1 66  ? -34.507 7.257   56.793 1.00 34.18 ? 83  TRP A CH2   1 
ATOM   1446 N N     . LEU B 1 67  ? -28.861 3.918   61.822 1.00 23.54 ? 84  LEU A N     1 
ATOM   1447 C CA    . LEU B 1 67  ? -28.362 3.674   63.167 1.00 24.34 ? 84  LEU A CA    1 
ATOM   1448 C C     . LEU B 1 67  ? -26.843 3.614   63.166 1.00 26.29 ? 84  LEU A C     1 
ATOM   1449 O O     . LEU B 1 67  ? -26.189 4.172   64.055 1.00 27.05 ? 84  LEU A O     1 
ATOM   1450 C CB    . LEU B 1 67  ? -28.953 2.365   63.701 1.00 22.11 ? 84  LEU A CB    1 
ATOM   1451 C CG    . LEU B 1 67  ? -29.145 2.162   65.201 1.00 31.61 ? 84  LEU A CG    1 
ATOM   1452 C CD1   . LEU B 1 67  ? -29.817 3.381   65.802 1.00 30.21 ? 84  LEU A CD1   1 
ATOM   1453 C CD2   . LEU B 1 67  ? -29.996 0.918   65.444 1.00 28.61 ? 84  LEU A CD2   1 
ATOM   1454 N N     . GLN B 1 68  ? -26.271 2.972   62.152 1.00 24.16 ? 85  GLN A N     1 
ATOM   1455 C CA    . GLN B 1 68  ? -24.798 2.810   62.114 1.00 27.24 ? 85  GLN A CA    1 
ATOM   1456 C C     . GLN B 1 68  ? -24.130 4.178   61.875 1.00 26.92 ? 85  GLN A C     1 
ATOM   1457 O O     . GLN B 1 68  ? -22.985 4.346   62.299 1.00 27.51 ? 85  GLN A O     1 
ATOM   1458 C CB    . GLN B 1 68  ? -24.387 1.782   61.060 1.00 30.11 ? 85  GLN A CB    1 
ATOM   1459 C CG    . GLN B 1 68  ? -24.365 0.355   61.589 1.00 38.14 ? 85  GLN A CG    1 
ATOM   1460 C CD    . GLN B 1 68  ? -24.449 -0.699  60.507 1.00 42.34 ? 85  GLN A CD    1 
ATOM   1461 O OE1   . GLN B 1 68  ? -23.437 -1.266  60.081 1.00 39.25 ? 85  GLN A OE1   1 
ATOM   1462 N NE2   . GLN B 1 68  ? -25.662 -0.977  60.056 1.00 47.28 ? 85  GLN A NE2   1 
ATOM   1463 N N     . GLN B 1 69  ? -24.831 5.099   61.219 1.00 22.93 ? 86  GLN A N     1 
ATOM   1464 C CA    . GLN B 1 69  ? -24.225 6.416   60.904 1.00 27.52 ? 86  GLN A CA    1 
ATOM   1465 C C     . GLN B 1 69  ? -24.424 7.386   62.068 1.00 23.24 ? 86  GLN A C     1 
ATOM   1466 O O     . GLN B 1 69  ? -23.759 8.420   62.093 1.00 24.45 ? 86  GLN A O     1 
ATOM   1467 C CB    . GLN B 1 69  ? -24.922 7.049   59.702 1.00 25.46 ? 86  GLN A CB    1 
ATOM   1468 C CG    . GLN B 1 69  ? -24.707 6.295   58.397 1.00 35.38 ? 86  GLN A CG    1 
ATOM   1469 C CD    . GLN B 1 69  ? -23.278 6.381   57.915 1.00 33.76 ? 86  GLN A CD    1 
ATOM   1470 O OE1   . GLN B 1 69  ? -22.638 7.432   58.007 1.00 38.76 ? 86  GLN A OE1   1 
ATOM   1471 N NE2   . GLN B 1 69  ? -22.763 5.277   57.400 1.00 36.21 ? 86  GLN A NE2   1 
ATOM   1472 N N     . ALA B 1 70  ? -25.253 7.011   63.031 1.00 26.26 ? 87  ALA A N     1 
ATOM   1473 C CA    . ALA B 1 70  ? -25.651 7.960   64.061 1.00 21.52 ? 87  ALA A CA    1 
ATOM   1474 C C     . ALA B 1 70  ? -24.532 8.199   65.066 1.00 26.55 ? 87  ALA A C     1 
ATOM   1475 O O     . ALA B 1 70  ? -23.805 7.279   65.459 1.00 27.31 ? 87  ALA A O     1 
ATOM   1476 C CB    . ALA B 1 70  ? -26.904 7.455   64.773 1.00 23.26 ? 87  ALA A CB    1 
ATOM   1477 N N     . ASP B 1 71  ? -24.383 9.461   65.464 1.00 21.76 ? 88  ASP A N     1 
ATOM   1478 C CA    . ASP B 1 71  ? -23.442 9.802   66.508 1.00 25.40 ? 88  ASP A CA    1 
ATOM   1479 C C     . ASP B 1 71  ? -24.097 9.735   67.868 1.00 23.06 ? 88  ASP A C     1 
ATOM   1480 O O     . ASP B 1 71  ? -23.436 9.402   68.857 1.00 26.88 ? 88  ASP A O     1 
ATOM   1481 C CB    . ASP B 1 71  ? -22.890 11.194  66.268 1.00 25.72 ? 88  ASP A CB    1 
ATOM   1482 C CG    . ASP B 1 71  ? -21.973 11.222  65.071 1.00 33.18 ? 88  ASP A CG    1 
ATOM   1483 O OD1   . ASP B 1 71  ? -22.320 11.916  64.090 1.00 37.59 ? 88  ASP A OD1   1 
ATOM   1484 O OD2   . ASP B 1 71  ? -20.949 10.497  65.079 1.00 31.47 ? 88  ASP A OD2   1 
ATOM   1485 N N     . VAL B 1 72  ? -25.379 10.074  67.928 1.00 23.37 ? 89  VAL A N     1 
ATOM   1486 C CA    . VAL B 1 72  ? -26.175 9.950   69.138 1.00 21.35 ? 89  VAL A CA    1 
ATOM   1487 C C     . VAL B 1 72  ? -27.534 9.401   68.735 1.00 20.24 ? 89  VAL A C     1 
ATOM   1488 O O     . VAL B 1 72  ? -28.108 9.804   67.718 1.00 19.53 ? 89  VAL A O     1 
ATOM   1489 C CB    . VAL B 1 72  ? -26.338 11.286  69.901 1.00 22.80 ? 89  VAL A CB    1 
ATOM   1490 C CG1   . VAL B 1 72  ? -27.087 11.042  71.194 1.00 21.67 ? 89  VAL A CG1   1 
ATOM   1491 C CG2   . VAL B 1 72  ? -24.974 11.954  70.192 1.00 25.39 ? 89  VAL A CG2   1 
ATOM   1492 N N     . VAL B 1 73  ? -28.036 8.473   69.536 1.00 18.14 ? 90  VAL A N     1 
ATOM   1493 C CA    . VAL B 1 73  ? -29.358 7.891   69.372 1.00 17.13 ? 90  VAL A CA    1 
ATOM   1494 C C     . VAL B 1 73  ? -30.219 8.460   70.486 1.00 21.14 ? 90  VAL A C     1 
ATOM   1495 O O     . VAL B 1 73  ? -29.906 8.278   71.670 1.00 21.66 ? 90  VAL A O     1 
ATOM   1496 C CB    . VAL B 1 73  ? -29.316 6.358   69.448 1.00 19.05 ? 90  VAL A CB    1 
ATOM   1497 C CG1   . VAL B 1 73  ? -30.734 5.782   69.438 1.00 20.06 ? 90  VAL A CG1   1 
ATOM   1498 C CG2   . VAL B 1 73  ? -28.470 5.785   68.302 1.00 20.78 ? 90  VAL A CG2   1 
ATOM   1499 N N     . VAL B 1 74  ? -31.290 9.153   70.116 1.00 15.45 ? 91  VAL A N     1 
ATOM   1500 C CA    . VAL B 1 74  ? -32.226 9.739   71.074 1.00 19.80 ? 91  VAL A CA    1 
ATOM   1501 C C     . VAL B 1 74  ? -33.536 8.979   70.970 1.00 18.91 ? 91  VAL A C     1 
ATOM   1502 O O     . VAL B 1 74  ? -34.133 8.904   69.886 1.00 19.57 ? 91  VAL A O     1 
ATOM   1503 C CB    . VAL B 1 74  ? -32.453 11.235  70.805 1.00 18.65 ? 91  VAL A CB    1 
ATOM   1504 C CG1   . VAL B 1 74  ? -33.506 11.786  71.793 1.00 20.48 ? 91  VAL A CG1   1 
ATOM   1505 C CG2   . VAL B 1 74  ? -31.149 12.002  70.882 1.00 21.79 ? 91  VAL A CG2   1 
ATOM   1506 N N     . ALA B 1 75  ? -34.002 8.422   72.090 1.00 17.79 ? 92  ALA A N     1 
ATOM   1507 C CA    . ALA B 1 75  ? -35.207 7.607   72.075 1.00 16.71 ? 92  ALA A CA    1 
ATOM   1508 C C     . ALA B 1 75  ? -36.190 8.142   73.102 1.00 19.64 ? 92  ALA A C     1 
ATOM   1509 O O     . ALA B 1 75  ? -35.821 8.351   74.260 1.00 21.74 ? 92  ALA A O     1 
ATOM   1510 C CB    . ALA B 1 75  ? -34.904 6.141   72.380 1.00 19.34 ? 92  ALA A CB    1 
ATOM   1511 N N     . GLU B 1 76  ? -37.429 8.363   72.683 1.00 16.58 ? 93  GLU A N     1 
ATOM   1512 C CA    . GLU B 1 76  ? -38.503 8.673   73.622 1.00 18.80 ? 93  GLU A CA    1 
ATOM   1513 C C     . GLU B 1 76  ? -39.120 7.331   73.985 1.00 21.66 ? 93  GLU A C     1 
ATOM   1514 O O     . GLU B 1 76  ? -39.693 6.662   73.121 1.00 22.37 ? 93  GLU A O     1 
ATOM   1515 C CB    . GLU B 1 76  ? -39.522 9.630   73.001 1.00 19.92 ? 93  GLU A CB    1 
ATOM   1516 C CG    . GLU B 1 76  ? -40.112 10.677  73.984 1.00 22.81 ? 93  GLU A CG    1 
ATOM   1517 C CD    . GLU B 1 76  ? -40.951 10.046  75.098 1.00 25.16 ? 93  GLU A CD    1 
ATOM   1518 O OE1   . GLU B 1 76  ? -41.293 8.847   74.978 1.00 23.21 ? 93  GLU A OE1   1 
ATOM   1519 O OE2   . GLU B 1 76  ? -41.278 10.743  76.089 1.00 25.60 ? 93  GLU A OE2   1 
ATOM   1520 N N     . VAL B 1 77  ? -38.960 6.915   75.237 1.00 18.71 ? 94  VAL A N     1 
ATOM   1521 C CA    . VAL B 1 77  ? -39.270 5.544   75.631 1.00 19.64 ? 94  VAL A CA    1 
ATOM   1522 C C     . VAL B 1 77  ? -40.508 5.485   76.529 1.00 19.80 ? 94  VAL A C     1 
ATOM   1523 O O     . VAL B 1 77  ? -40.690 4.524   77.281 1.00 19.85 ? 94  VAL A O     1 
ATOM   1524 C CB    . VAL B 1 77  ? -38.054 4.882   76.303 1.00 19.19 ? 94  VAL A CB    1 
ATOM   1525 C CG1   . VAL B 1 77  ? -36.907 4.747   75.297 1.00 19.23 ? 94  VAL A CG1   1 
ATOM   1526 C CG2   . VAL B 1 77  ? -37.607 5.658   77.557 1.00 19.46 ? 94  VAL A CG2   1 
ATOM   1527 N N     . THR B 1 78  ? -41.371 6.502   76.479 1.00 18.20 ? 95  THR A N     1 
ATOM   1528 C CA    . THR B 1 78  ? -42.572 6.446   77.309 1.00 19.95 ? 95  THR A CA    1 
ATOM   1529 C C     . THR B 1 78  ? -43.598 5.479   76.746 1.00 21.14 ? 95  THR A C     1 
ATOM   1530 O O     . THR B 1 78  ? -44.132 4.642   77.476 1.00 22.16 ? 95  THR A O     1 
ATOM   1531 C CB    . THR B 1 78  ? -43.167 7.844   77.473 1.00 20.40 ? 95  THR A CB    1 
ATOM   1532 O OG1   . THR B 1 78  ? -42.150 8.698   78.005 1.00 21.05 ? 95  THR A OG1   1 
ATOM   1533 C CG2   . THR B 1 78  ? -44.371 7.806   78.429 1.00 23.36 ? 95  THR A CG2   1 
ATOM   1534 N N     . GLN B 1 79  ? -43.885 5.573   75.453 1.00 20.52 ? 96  GLN A N     1 
ATOM   1535 C CA    . GLN B 1 79  ? -44.861 4.686   74.836 1.00 18.76 ? 96  GLN A CA    1 
ATOM   1536 C C     . GLN B 1 79  ? -44.205 3.355   74.479 1.00 21.72 ? 96  GLN A C     1 
ATOM   1537 O O     . GLN B 1 79  ? -43.223 3.354   73.737 1.00 20.20 ? 96  GLN A O     1 
ATOM   1538 C CB    . GLN B 1 79  ? -45.423 5.336   73.593 1.00 21.11 ? 96  GLN A CB    1 
ATOM   1539 C CG    . GLN B 1 79  ? -46.521 4.549   72.944 1.00 22.57 ? 96  GLN A CG    1 
ATOM   1540 C CD    . GLN B 1 79  ? -47.770 4.519   73.799 1.00 28.12 ? 96  GLN A CD    1 
ATOM   1541 O OE1   . GLN B 1 79  ? -48.109 5.505   74.470 1.00 28.62 ? 96  GLN A OE1   1 
ATOM   1542 N NE2   . GLN B 1 79  ? -48.469 3.389   73.776 1.00 27.91 ? 96  GLN A NE2   1 
ATOM   1543 N N     . PRO B 1 80  ? -44.697 2.218   74.987 1.00 22.30 ? 97  PRO A N     1 
ATOM   1544 C CA    . PRO B 1 80  ? -44.030 0.939   74.701 1.00 20.59 ? 97  PRO A CA    1 
ATOM   1545 C C     . PRO B 1 80  ? -44.000 0.650   73.212 1.00 18.66 ? 97  PRO A C     1 
ATOM   1546 O O     . PRO B 1 80  ? -44.989 0.831   72.496 1.00 20.57 ? 97  PRO A O     1 
ATOM   1547 C CB    . PRO B 1 80  ? -44.879 -0.088  75.462 1.00 24.67 ? 97  PRO A CB    1 
ATOM   1548 C CG    . PRO B 1 80  ? -45.440 0.741   76.624 1.00 24.49 ? 97  PRO A CG    1 
ATOM   1549 C CD    . PRO B 1 80  ? -45.812 2.036   75.936 1.00 26.20 ? 97  PRO A CD    1 
ATOM   1550 N N     . SER B 1 81  ? -42.841 0.192   72.747 1.00 19.39 ? 98  SER A N     1 
ATOM   1551 C CA    . SER B 1 81  ? -42.662 -0.045  71.319 1.00 17.08 ? 98  SER A CA    1 
ATOM   1552 C C     . SER B 1 81  ? -41.589 -1.106  71.128 1.00 15.48 ? 98  SER A C     1 
ATOM   1553 O O     . SER B 1 81  ? -40.470 -0.952  71.628 1.00 16.82 ? 98  SER A O     1 
ATOM   1554 C CB    . SER B 1 81  ? -42.284 1.255   70.600 1.00 20.14 ? 98  SER A CB    1 
ATOM   1555 O OG    . SER B 1 81  ? -41.670 0.981   69.350 1.00 18.64 ? 98  SER A OG    1 
ATOM   1556 N N     . LEU B 1 82  ? -41.932 -2.191  70.433 1.00 16.59 ? 99  LEU A N     1 
ATOM   1557 C CA    . LEU B 1 82  ? -40.922 -3.177  70.055 1.00 16.77 ? 99  LEU A CA    1 
ATOM   1558 C C     . LEU B 1 82  ? -39.821 -2.549  69.220 1.00 19.31 ? 99  LEU A C     1 
ATOM   1559 O O     . LEU B 1 82  ? -38.632 -2.829  69.428 1.00 17.99 ? 99  LEU A O     1 
ATOM   1560 C CB    . LEU B 1 82  ? -41.573 -4.319  69.267 1.00 19.80 ? 99  LEU A CB    1 
ATOM   1561 C CG    . LEU B 1 82  ? -42.418 -5.291  70.075 1.00 19.73 ? 99  LEU A CG    1 
ATOM   1562 C CD1   . LEU B 1 82  ? -43.194 -6.165  69.087 1.00 20.42 ? 99  LEU A CD1   1 
ATOM   1563 C CD2   . LEU B 1 82  ? -41.545 -6.130  71.004 1.00 18.90 ? 99  LEU A CD2   1 
ATOM   1564 N N     . GLY B 1 83  ? -40.200 -1.715  68.257 1.00 15.04 ? 100 GLY A N     1 
ATOM   1565 C CA    . GLY B 1 83  ? -39.219 -1.122  67.353 1.00 16.53 ? 100 GLY A CA    1 
ATOM   1566 C C     . GLY B 1 83  ? -38.222 -0.219  68.054 1.00 15.95 ? 100 GLY A C     1 
ATOM   1567 O O     . GLY B 1 83  ? -37.022 -0.267  67.771 1.00 16.57 ? 100 GLY A O     1 
ATOM   1568 N N     . VAL B 1 84  ? -38.702 0.624   68.975 1.00 16.51 ? 101 VAL A N     1 
ATOM   1569 C CA    . VAL B 1 84  ? -37.793 1.470   69.747 1.00 15.91 ? 101 VAL A CA    1 
ATOM   1570 C C     . VAL B 1 84  ? -36.836 0.617   70.571 1.00 16.15 ? 101 VAL A C     1 
ATOM   1571 O O     . VAL B 1 84  ? -35.620 0.840   70.568 1.00 17.27 ? 101 VAL A O     1 
ATOM   1572 C CB    . VAL B 1 84  ? -38.599 2.447   70.625 1.00 18.63 ? 101 VAL A CB    1 
ATOM   1573 C CG1   . VAL B 1 84  ? -37.667 3.235   71.525 1.00 19.47 ? 101 VAL A CG1   1 
ATOM   1574 C CG2   . VAL B 1 84  ? -39.431 3.364   69.719 1.00 19.61 ? 101 VAL A CG2   1 
ATOM   1575 N N     . GLY B 1 85  ? -37.366 -0.395  71.269 1.00 16.20 ? 102 GLY A N     1 
ATOM   1576 C CA    . GLY B 1 85  ? -36.501 -1.237  72.068 1.00 16.66 ? 102 GLY A CA    1 
ATOM   1577 C C     . GLY B 1 85  ? -35.469 -1.940  71.204 1.00 14.45 ? 102 GLY A C     1 
ATOM   1578 O O     . GLY B 1 85  ? -34.287 -1.967  71.536 1.00 15.14 ? 102 GLY A O     1 
ATOM   1579 N N     . TYR B 1 86  ? -35.890 -2.438  70.046 1.00 16.62 ? 103 TYR A N     1 
ATOM   1580 C CA    . TYR B 1 86  ? -34.966 -3.178  69.130 1.00 15.94 ? 103 TYR A CA    1 
ATOM   1581 C C     . TYR B 1 86  ? -33.825 -2.264  68.645 1.00 17.82 ? 103 TYR A C     1 
ATOM   1582 O O     . TYR B 1 86  ? -32.676 -2.689  68.589 1.00 16.14 ? 103 TYR A O     1 
ATOM   1583 C CB    . TYR B 1 86  ? -35.772 -3.734  67.957 1.00 15.57 ? 103 TYR A CB    1 
ATOM   1584 C CG    . TYR B 1 86  ? -34.937 -4.416  66.887 1.00 16.66 ? 103 TYR A CG    1 
ATOM   1585 C CD1   . TYR B 1 86  ? -34.619 -5.762  66.985 1.00 18.10 ? 103 TYR A CD1   1 
ATOM   1586 C CD2   . TYR B 1 86  ? -34.469 -3.717  65.783 1.00 17.42 ? 103 TYR A CD2   1 
ATOM   1587 C CE1   . TYR B 1 86  ? -33.856 -6.393  66.019 1.00 17.89 ? 103 TYR A CE1   1 
ATOM   1588 C CE2   . TYR B 1 86  ? -33.709 -4.337  64.809 1.00 17.09 ? 103 TYR A CE2   1 
ATOM   1589 C CZ    . TYR B 1 86  ? -33.397 -5.678  64.930 1.00 17.75 ? 103 TYR A CZ    1 
ATOM   1590 O OH    . TYR B 1 86  ? -32.646 -6.298  63.981 1.00 23.01 ? 103 TYR A OH    1 
ATOM   1591 N N     . GLU B 1 87  ? -34.171 -1.024  68.298 1.00 16.64 ? 104 GLU A N     1 
ATOM   1592 C CA    . GLU B 1 87  ? -33.145 -0.058  67.831 1.00 18.02 ? 104 GLU A CA    1 
ATOM   1593 C C     . GLU B 1 87  ? -32.165 0.233   68.973 1.00 19.45 ? 104 GLU A C     1 
ATOM   1594 O O     . GLU B 1 87  ? -30.981 0.341   68.709 1.00 19.67 ? 104 GLU A O     1 
ATOM   1595 C CB    . GLU B 1 87  ? -33.815 1.200   67.280 1.00 22.05 ? 104 GLU A CB    1 
ATOM   1596 C CG    . GLU B 1 87  ? -34.650 0.944   66.032 1.00 20.24 ? 104 GLU A CG    1 
ATOM   1597 C CD    . GLU B 1 87  ? -35.498 2.123   65.598 1.00 29.13 ? 104 GLU A CD    1 
ATOM   1598 O OE1   . GLU B 1 87  ? -36.099 2.810   66.444 1.00 29.72 ? 104 GLU A OE1   1 
ATOM   1599 O OE2   . GLU B 1 87  ? -35.550 2.346   64.383 1.00 35.93 ? 104 GLU A OE2   1 
ATOM   1600 N N     . LEU B 1 88  ? -32.685 0.357   70.190 1.00 15.55 ? 105 LEU A N     1 
ATOM   1601 C CA    . LEU B 1 88  ? -31.804 0.601   71.349 1.00 17.68 ? 105 LEU A CA    1 
ATOM   1602 C C     . LEU B 1 88  ? -30.837 -0.579  71.502 1.00 21.51 ? 105 LEU A C     1 
ATOM   1603 O O     . LEU B 1 88  ? -29.650 -0.356  71.710 1.00 21.14 ? 105 LEU A O     1 
ATOM   1604 C CB    . LEU B 1 88  ? -32.676 0.795   72.584 1.00 19.28 ? 105 LEU A CB    1 
ATOM   1605 C CG    . LEU B 1 88  ? -33.380 2.151   72.665 1.00 20.94 ? 105 LEU A CG    1 
ATOM   1606 C CD1   . LEU B 1 88  ? -34.204 2.289   73.925 1.00 18.55 ? 105 LEU A CD1   1 
ATOM   1607 C CD2   . LEU B 1 88  ? -32.360 3.264   72.558 1.00 21.47 ? 105 LEU A CD2   1 
ATOM   1608 N N     . GLY B 1 89  ? -31.382 -1.786  71.387 1.00 19.40 ? 106 GLY A N     1 
ATOM   1609 C CA    . GLY B 1 89  ? -30.524 -2.944  71.559 1.00 22.24 ? 106 GLY A CA    1 
ATOM   1610 C C     . GLY B 1 89  ? -29.470 -3.036  70.476 1.00 19.71 ? 106 GLY A C     1 
ATOM   1611 O O     . GLY B 1 89  ? -28.300 -3.305  70.761 1.00 22.14 ? 106 GLY A O     1 
ATOM   1612 N N     . ARG B 1 90  ? -29.862 -2.786  69.222 1.00 21.22 ? 107 ARG A N     1 
ATOM   1613 C CA    . ARG B 1 90  ? -28.874 -2.707  68.147 1.00 22.34 ? 107 ARG A CA    1 
ATOM   1614 C C     . ARG B 1 90  ? -27.891 -1.567  68.401 1.00 23.91 ? 107 ARG A C     1 
ATOM   1615 O O     . ARG B 1 90  ? -26.678 -1.725  68.213 1.00 24.42 ? 107 ARG A O     1 
ATOM   1616 C CB    . ARG B 1 90  ? -29.560 -2.514  66.790 1.00 16.85 ? 107 ARG A CB    1 
ATOM   1617 C CG    . ARG B 1 90  ? -30.508 -3.638  66.358 1.00 22.29 ? 107 ARG A CG    1 
ATOM   1618 C CD    . ARG B 1 90  ? -29.852 -5.030  66.312 1.00 20.27 ? 107 ARG A CD    1 
ATOM   1619 N NE    . ARG B 1 90  ? -28.686 -5.110  65.436 1.00 20.48 ? 107 ARG A NE    1 
ATOM   1620 C CZ    . ARG B 1 90  ? -28.728 -5.531  64.178 1.00 20.81 ? 107 ARG A CZ    1 
ATOM   1621 N NH1   . ARG B 1 90  ? -29.871 -5.857  63.589 1.00 21.87 ? 107 ARG A NH1   1 
ATOM   1622 N NH2   . ARG B 1 90  ? -27.593 -5.647  63.492 1.00 24.32 ? 107 ARG A NH2   1 
ATOM   1623 N N     . ALA B 1 91  ? -28.393 -0.415  68.858 1.00 20.70 ? 108 ALA A N     1 
ATOM   1624 C CA    . ALA B 1 91  ? -27.511 0.732   69.081 1.00 22.53 ? 108 ALA A CA    1 
ATOM   1625 C C     . ALA B 1 91  ? -26.492 0.457   70.181 1.00 23.20 ? 108 ALA A C     1 
ATOM   1626 O O     . ALA B 1 91  ? -25.335 0.887   70.080 1.00 24.08 ? 108 ALA A O     1 
ATOM   1627 C CB    . ALA B 1 91  ? -28.324 1.983   69.426 1.00 22.10 ? 108 ALA A CB    1 
ATOM   1628 N N     . VAL B 1 92  ? -26.902 -0.236  71.249 1.00 23.53 ? 109 VAL A N     1 
ATOM   1629 C CA    . VAL B 1 92  ? -25.950 -0.583  72.303 1.00 26.76 ? 109 VAL A CA    1 
ATOM   1630 C C     . VAL B 1 92  ? -24.833 -1.442  71.725 1.00 32.57 ? 109 VAL A C     1 
ATOM   1631 O O     . VAL B 1 92  ? -23.641 -1.200  71.958 1.00 32.54 ? 109 VAL A O     1 
ATOM   1632 C CB    . VAL B 1 92  ? -26.659 -1.297  73.466 1.00 27.18 ? 109 VAL A CB    1 
ATOM   1633 C CG1   . VAL B 1 92  ? -25.631 -1.916  74.400 1.00 36.84 ? 109 VAL A CG1   1 
ATOM   1634 C CG2   . VAL B 1 92  ? -27.569 -0.331  74.221 1.00 24.22 ? 109 VAL A CG2   1 
ATOM   1635 N N     . ALA B 1 93  ? -25.208 -2.440  70.925 1.00 27.60 ? 110 ALA A N     1 
ATOM   1636 C CA    . ALA B 1 93  ? -24.209 -3.307  70.309 1.00 31.70 ? 110 ALA A CA    1 
ATOM   1637 C C     . ALA B 1 93  ? -23.339 -2.569  69.301 1.00 30.86 ? 110 ALA A C     1 
ATOM   1638 O O     . ALA B 1 93  ? -22.203 -2.987  69.054 1.00 37.45 ? 110 ALA A O     1 
ATOM   1639 C CB    . ALA B 1 93  ? -24.903 -4.483  69.644 1.00 32.64 ? 110 ALA A CB    1 
ATOM   1640 N N     . PHE B 1 94  ? -23.845 -1.490  68.688 1.00 30.04 ? 111 PHE A N     1 
ATOM   1641 C CA    . PHE B 1 94  ? -22.990 -0.631  67.876 1.00 30.71 ? 111 PHE A CA    1 
ATOM   1642 C C     . PHE B 1 94  ? -22.171 0.360   68.714 1.00 32.74 ? 111 PHE A C     1 
ATOM   1643 O O     . PHE B 1 94  ? -21.538 1.253   68.138 1.00 35.51 ? 111 PHE A O     1 
ATOM   1644 C CB    . PHE B 1 94  ? -23.812 0.142   66.844 1.00 30.26 ? 111 PHE A CB    1 
ATOM   1645 C CG    . PHE B 1 94  ? -24.400 -0.711  65.746 1.00 30.60 ? 111 PHE A CG    1 
ATOM   1646 C CD1   . PHE B 1 94  ? -23.682 -1.762  65.196 1.00 32.85 ? 111 PHE A CD1   1 
ATOM   1647 C CD2   . PHE B 1 94  ? -25.657 -0.419  65.224 1.00 30.30 ? 111 PHE A CD2   1 
ATOM   1648 C CE1   . PHE B 1 94  ? -24.222 -2.532  64.170 1.00 32.50 ? 111 PHE A CE1   1 
ATOM   1649 C CE2   . PHE B 1 94  ? -26.198 -1.179  64.207 1.00 33.00 ? 111 PHE A CE2   1 
ATOM   1650 C CZ    . PHE B 1 94  ? -25.472 -2.237  63.671 1.00 30.98 ? 111 PHE A CZ    1 
ATOM   1651 N N     . ASN B 1 95  ? -22.180 0.219   70.042 1.00 33.15 ? 112 ASN A N     1 
ATOM   1652 C CA    . ASN B 1 95  ? -21.467 1.112   70.967 1.00 36.20 ? 112 ASN A CA    1 
ATOM   1653 C C     . ASN B 1 95  ? -21.840 2.576   70.744 1.00 32.68 ? 112 ASN A C     1 
ATOM   1654 O O     . ASN B 1 95  ? -20.984 3.465   70.769 1.00 34.92 ? 112 ASN A O     1 
ATOM   1655 C CB    . ASN B 1 95  ? -19.949 0.925   70.866 1.00 36.91 ? 112 ASN A CB    1 
ATOM   1656 C CG    . ASN B 1 95  ? -19.541 -0.536  70.812 1.00 44.65 ? 112 ASN A CG    1 
ATOM   1657 O OD1   . ASN B 1 95  ? -18.940 -0.992  69.836 1.00 48.73 ? 112 ASN A OD1   1 
ATOM   1658 N ND2   . ASN B 1 95  ? -19.874 -1.282  71.861 1.00 48.40 ? 112 ASN A ND2   1 
ATOM   1659 N N     . LYS B 1 96  ? -23.124 2.834   70.506 1.00 29.26 ? 113 LYS A N     1 
ATOM   1660 C CA    . LYS B 1 96  ? -23.578 4.193   70.233 1.00 27.67 ? 113 LYS A CA    1 
ATOM   1661 C C     . LYS B 1 96  ? -23.871 4.925   71.542 1.00 28.89 ? 113 LYS A C     1 
ATOM   1662 O O     . LYS B 1 96  ? -24.255 4.315   72.543 1.00 25.78 ? 113 LYS A O     1 
ATOM   1663 C CB    . LYS B 1 96  ? -24.834 4.200   69.349 1.00 27.71 ? 113 LYS A CB    1 
ATOM   1664 C CG    . LYS B 1 96  ? -24.659 3.695   67.919 1.00 28.02 ? 113 LYS A CG    1 
ATOM   1665 C CD    . LYS B 1 96  ? -23.585 4.454   67.175 1.00 27.80 ? 113 LYS A CD    1 
ATOM   1666 C CE    . LYS B 1 96  ? -23.431 3.920   65.751 1.00 27.01 ? 113 LYS A CE    1 
ATOM   1667 N NZ    . LYS B 1 96  ? -22.758 4.890   64.860 1.00 29.42 ? 113 LYS A NZ    1 
ATOM   1668 N N     . ARG B 1 97  ? -23.677 6.242   71.523 1.00 23.64 ? 114 ARG A N     1 
ATOM   1669 C CA    . ARG B 1 97  ? -24.090 7.087   72.633 1.00 27.07 ? 114 ARG A CA    1 
ATOM   1670 C C     . ARG B 1 97  ? -25.606 7.236   72.574 1.00 24.71 ? 114 ARG A C     1 
ATOM   1671 O O     . ARG B 1 97  ? -26.171 7.543   71.521 1.00 21.99 ? 114 ARG A O     1 
ATOM   1672 C CB    . ARG B 1 97  ? -23.383 8.443   72.541 1.00 29.14 ? 114 ARG A CB    1 
ATOM   1673 C CG    . ARG B 1 97  ? -23.434 9.324   73.773 1.00 37.51 ? 114 ARG A CG    1 
ATOM   1674 C CD    . ARG B 1 97  ? -22.443 10.511  73.620 1.00 38.37 ? 114 ARG A CD    1 
ATOM   1675 N NE    . ARG B 1 97  ? -22.662 11.611  74.560 1.00 48.89 ? 114 ARG A NE    1 
ATOM   1676 C CZ    . ARG B 1 97  ? -22.773 11.495  75.881 1.00 51.12 ? 114 ARG A CZ    1 
ATOM   1677 N NH1   . ARG B 1 97  ? -22.607 10.337  76.496 1.00 50.11 ? 114 ARG A NH1   1 
ATOM   1678 N NH2   . ARG B 1 97  ? -23.030 12.579  76.609 1.00 52.11 ? 114 ARG A NH2   1 
ATOM   1679 N N     . ILE B 1 98  ? -26.279 6.953   73.678 1.00 21.30 ? 115 ILE A N     1 
ATOM   1680 C CA    . ILE B 1 98  ? -27.732 6.844   73.667 1.00 19.70 ? 115 ILE A CA    1 
ATOM   1681 C C     . ILE B 1 98  ? -28.310 7.744   74.746 1.00 22.15 ? 115 ILE A C     1 
ATOM   1682 O O     . ILE B 1 98  ? -27.842 7.732   75.884 1.00 20.21 ? 115 ILE A O     1 
ATOM   1683 C CB    . ILE B 1 98  ? -28.176 5.385   73.882 1.00 21.99 ? 115 ILE A CB    1 
ATOM   1684 C CG1   . ILE B 1 98  ? -27.762 4.517   72.687 1.00 23.43 ? 115 ILE A CG1   1 
ATOM   1685 C CG2   . ILE B 1 98  ? -29.682 5.289   74.162 1.00 22.87 ? 115 ILE A CG2   1 
ATOM   1686 C CD1   . ILE B 1 98  ? -27.799 3.024   72.994 1.00 24.35 ? 115 ILE A CD1   1 
ATOM   1687 N N     . LEU B 1 99  ? -29.347 8.490   74.397 1.00 19.48 ? 116 LEU A N     1 
ATOM   1688 C CA    . LEU B 1 99  ? -30.112 9.273   75.358 1.00 20.51 ? 116 LEU A CA    1 
ATOM   1689 C C     . LEU B 1 99  ? -31.555 8.805   75.301 1.00 18.03 ? 116 LEU A C     1 
ATOM   1690 O O     . LEU B 1 99  ? -32.200 8.898   74.246 1.00 18.48 ? 116 LEU A O     1 
ATOM   1691 C CB    . LEU B 1 99  ? -30.014 10.769  75.050 1.00 20.75 ? 116 LEU A CB    1 
ATOM   1692 C CG    . LEU B 1 99  ? -30.959 11.646  75.874 1.00 22.97 ? 116 LEU A CG    1 
ATOM   1693 C CD1   . LEU B 1 99  ? -30.660 11.499  77.351 1.00 23.14 ? 116 LEU A CD1   1 
ATOM   1694 C CD2   . LEU B 1 99  ? -30.844 13.116  75.405 1.00 22.08 ? 116 LEU A CD2   1 
ATOM   1695 N N     . CYS B 1 100 ? -32.060 8.294   76.422 1.00 21.11 ? 117 CYS A N     1 
ATOM   1696 C CA    . CYS B 1 100 ? -33.448 7.883   76.522 1.00 17.59 ? 117 CYS A CA    1 
ATOM   1697 C C     . CYS B 1 100 ? -34.219 8.901   77.349 1.00 21.42 ? 117 CYS A C     1 
ATOM   1698 O O     . CYS B 1 100 ? -33.745 9.340   78.400 1.00 22.46 ? 117 CYS A O     1 
ATOM   1699 C CB    . CYS B 1 100 ? -33.581 6.517   77.175 1.00 18.69 ? 117 CYS A CB    1 
ATOM   1700 S SG    . CYS B 1 100 ? -33.080 5.204   76.074 1.00 23.30 ? 117 CYS A SG    1 
ATOM   1701 N N     . LEU B 1 101 ? -35.425 9.215   76.893 1.00 20.45 ? 118 LEU A N     1 
ATOM   1702 C CA    . LEU B 1 101 ? -36.293 10.210  77.513 1.00 22.31 ? 118 LEU A CA    1 
ATOM   1703 C C     . LEU B 1 101 ? -37.569 9.524   77.973 1.00 19.05 ? 118 LEU A C     1 
ATOM   1704 O O     . LEU B 1 101 ? -38.308 8.974   77.151 1.00 21.20 ? 118 LEU A O     1 
ATOM   1705 C CB    . LEU B 1 101 ? -36.610 11.316  76.505 1.00 20.78 ? 118 LEU A CB    1 
ATOM   1706 C CG    . LEU B 1 101 ? -35.376 12.092  76.038 1.00 23.65 ? 118 LEU A CG    1 
ATOM   1707 C CD1   . LEU B 1 101 ? -35.725 13.144  74.974 1.00 23.81 ? 118 LEU A CD1   1 
ATOM   1708 C CD2   . LEU B 1 101 ? -34.657 12.703  77.225 1.00 25.50 ? 118 LEU A CD2   1 
ATOM   1709 N N     . PHE B 1 102 ? -37.846 9.570   79.278 1.00 20.12 ? 119 PHE A N     1 
ATOM   1710 C CA    . PHE B 1 102 ? -39.000 8.871   79.824 1.00 20.27 ? 119 PHE A CA    1 
ATOM   1711 C C     . PHE B 1 102 ? -39.832 9.839   80.654 1.00 22.88 ? 119 PHE A C     1 
ATOM   1712 O O     . PHE B 1 102 ? -39.268 10.642  81.403 1.00 22.02 ? 119 PHE A O     1 
ATOM   1713 C CB    . PHE B 1 102 ? -38.565 7.684   80.685 1.00 22.65 ? 119 PHE A CB    1 
ATOM   1714 C CG    . PHE B 1 102 ? -39.707 6.976   81.326 1.00 21.97 ? 119 PHE A CG    1 
ATOM   1715 C CD1   . PHE B 1 102 ? -40.587 6.223   80.560 1.00 21.49 ? 119 PHE A CD1   1 
ATOM   1716 C CD2   . PHE B 1 102 ? -39.938 7.114   82.685 1.00 24.08 ? 119 PHE A CD2   1 
ATOM   1717 C CE1   . PHE B 1 102 ? -41.659 5.578   81.145 1.00 25.51 ? 119 PHE A CE1   1 
ATOM   1718 C CE2   . PHE B 1 102 ? -41.020 6.471   83.284 1.00 25.90 ? 119 PHE A CE2   1 
ATOM   1719 C CZ    . PHE B 1 102 ? -41.884 5.714   82.512 1.00 24.06 ? 119 PHE A CZ    1 
ATOM   1720 N N     . ARG B 1 103 ? -41.163 9.760   80.522 1.00 22.05 ? 120 ARG A N     1 
ATOM   1721 C CA    . ARG B 1 103 ? -42.058 10.641  81.280 1.00 23.82 ? 120 ARG A CA    1 
ATOM   1722 C C     . ARG B 1 103 ? -42.763 9.862   82.377 1.00 23.37 ? 120 ARG A C     1 
ATOM   1723 O O     . ARG B 1 103 ? -43.808 9.238   82.126 1.00 24.33 ? 120 ARG A O     1 
ATOM   1724 C CB    . ARG B 1 103 ? -43.090 11.308  80.366 1.00 21.59 ? 120 ARG A CB    1 
ATOM   1725 C CG    . ARG B 1 103 ? -42.469 12.109  79.255 1.00 25.04 ? 120 ARG A CG    1 
ATOM   1726 C CD    . ARG B 1 103 ? -43.507 12.945  78.513 1.00 28.42 ? 120 ARG A CD    1 
ATOM   1727 N NE    . ARG B 1 103 ? -44.796 12.276  78.360 1.00 24.76 ? 120 ARG A NE    1 
ATOM   1728 C CZ    . ARG B 1 103 ? -45.110 11.490  77.340 1.00 28.44 ? 120 ARG A CZ    1 
ATOM   1729 N NH1   . ARG B 1 103 ? -44.198 11.105  76.462 1.00 25.43 ? 120 ARG A NH1   1 
ATOM   1730 N NH2   . ARG B 1 103 ? -46.367 11.062  77.210 1.00 29.85 ? 120 ARG A NH2   1 
ATOM   1731 N N     . PRO B 1 104 ? -42.261 9.877   83.612 1.00 24.33 ? 121 PRO A N     1 
ATOM   1732 C CA    . PRO B 1 104 ? -42.947 9.136   84.674 1.00 25.99 ? 121 PRO A CA    1 
ATOM   1733 C C     . PRO B 1 104 ? -44.324 9.691   85.008 1.00 24.87 ? 121 PRO A C     1 
ATOM   1734 O O     . PRO B 1 104 ? -45.104 8.979   85.653 1.00 26.19 ? 121 PRO A O     1 
ATOM   1735 C CB    . PRO B 1 104 ? -41.971 9.256   85.853 1.00 23.44 ? 121 PRO A CB    1 
ATOM   1736 C CG    . PRO B 1 104 ? -41.322 10.527  85.607 1.00 26.01 ? 121 PRO A CG    1 
ATOM   1737 C CD    . PRO B 1 104 ? -41.035 10.501  84.127 1.00 26.64 ? 121 PRO A CD    1 
ATOM   1738 N N     . GLN B 1 105 ? -44.670 10.914  84.571 1.00 25.45 ? 122 GLN A N     1 
ATOM   1739 C CA    . GLN B 1 105 ? -46.047 11.386  84.753 1.00 28.19 ? 122 GLN A CA    1 
ATOM   1740 C C     . GLN B 1 105 ? -47.035 10.580  83.931 1.00 29.90 ? 122 GLN A C     1 
ATOM   1741 O O     . GLN B 1 105 ? -48.242 10.651  84.187 1.00 28.69 ? 122 GLN A O     1 
ATOM   1742 C CB    . GLN B 1 105 ? -46.195 12.873  84.404 1.00 28.86 ? 122 GLN A CB    1 
ATOM   1743 C CG    . GLN B 1 105 ? -46.111 13.791  85.608 1.00 38.92 ? 122 GLN A CG    1 
ATOM   1744 C CD    . GLN B 1 105 ? -45.546 15.163  85.281 1.00 48.29 ? 122 GLN A CD    1 
ATOM   1745 O OE1   . GLN B 1 105 ? -46.176 15.965  84.591 0.83 50.09 ? 122 GLN A OE1   1 
ATOM   1746 N NE2   . GLN B 1 105 ? -44.360 15.443  85.792 0.58 44.84 ? 122 GLN A NE2   1 
ATOM   1747 N N     . SER B 1 106 ? -46.550 9.807   82.960 1.00 27.47 ? 123 SER A N     1 
ATOM   1748 C CA    . SER B 1 106 ? -47.416 8.864   82.266 1.00 27.92 ? 123 SER A CA    1 
ATOM   1749 C C     . SER B 1 106 ? -48.016 7.836   83.211 1.00 25.22 ? 123 SER A C     1 
ATOM   1750 O O     . SER B 1 106 ? -48.986 7.166   82.842 1.00 27.73 ? 123 SER A O     1 
ATOM   1751 C CB    . SER B 1 106 ? -46.623 8.119   81.196 1.00 29.27 ? 123 SER A CB    1 
ATOM   1752 O OG    . SER B 1 106 ? -45.621 7.339   81.834 1.00 26.77 ? 123 SER A OG    1 
ATOM   1753 N N     . GLY B 1 107 ? -47.421 7.649   84.392 1.00 26.33 ? 124 GLY A N     1 
ATOM   1754 C CA    . GLY B 1 107 ? -47.838 6.616   85.316 1.00 29.45 ? 124 GLY A CA    1 
ATOM   1755 C C     . GLY B 1 107 ? -47.336 5.234   84.974 1.00 29.51 ? 124 GLY A C     1 
ATOM   1756 O O     . GLY B 1 107 ? -47.649 4.277   85.698 1.00 26.30 ? 124 GLY A O     1 
ATOM   1757 N N     . ARG B 1 108 ? -46.577 5.094   83.890 1.00 28.13 ? 125 ARG A N     1 
ATOM   1758 C CA    . ARG B 1 108 ? -45.970 3.819   83.555 1.00 26.69 ? 125 ARG A CA    1 
ATOM   1759 C C     . ARG B 1 108 ? -44.692 3.625   84.358 1.00 29.63 ? 125 ARG A C     1 
ATOM   1760 O O     . ARG B 1 108 ? -44.116 4.574   84.894 1.00 28.98 ? 125 ARG A O     1 
ATOM   1761 C CB    . ARG B 1 108 ? -45.651 3.763   82.067 1.00 26.59 ? 125 ARG A CB    1 
ATOM   1762 C CG    . ARG B 1 108 ? -46.836 3.962   81.153 1.00 26.91 ? 125 ARG A CG    1 
ATOM   1763 C CD    . ARG B 1 108 ? -46.368 4.007   79.710 1.00 25.44 ? 125 ARG A CD    1 
ATOM   1764 N NE    . ARG B 1 108 ? -47.440 4.349   78.784 1.00 26.56 ? 125 ARG A NE    1 
ATOM   1765 C CZ    . ARG B 1 108 ? -48.234 3.467   78.201 1.00 31.32 ? 125 ARG A CZ    1 
ATOM   1766 N NH1   . ARG B 1 108 ? -48.085 2.169   78.409 1.00 30.59 ? 125 ARG A NH1   1 
ATOM   1767 N NH2   . ARG B 1 108 ? -49.191 3.897   77.379 1.00 31.71 ? 125 ARG A NH2   1 
ATOM   1768 N N     . VAL B 1 109 ? -44.250 2.375   84.445 1.00 24.05 ? 126 VAL A N     1 
ATOM   1769 C CA    . VAL B 1 109 ? -42.912 2.060   84.936 1.00 26.19 ? 126 VAL A CA    1 
ATOM   1770 C C     . VAL B 1 109 ? -42.066 1.673   83.739 1.00 27.15 ? 126 VAL A C     1 
ATOM   1771 O O     . VAL B 1 109 ? -42.421 0.754   82.995 1.00 28.64 ? 126 VAL A O     1 
ATOM   1772 C CB    . VAL B 1 109 ? -42.924 0.940   85.984 1.00 27.05 ? 126 VAL A CB    1 
ATOM   1773 C CG1   . VAL B 1 109 ? -41.513 0.684   86.495 1.00 32.21 ? 126 VAL A CG1   1 
ATOM   1774 C CG2   . VAL B 1 109 ? -43.814 1.341   87.140 1.00 30.63 ? 126 VAL A CG2   1 
ATOM   1775 N N     . LEU B 1 110 ? -40.961 2.378   83.552 1.00 27.22 ? 127 LEU A N     1 
ATOM   1776 C CA    . LEU B 1 110 ? -40.054 2.060   82.462 1.00 26.55 ? 127 LEU A CA    1 
ATOM   1777 C C     . LEU B 1 110 ? -39.490 0.658   82.622 1.00 27.92 ? 127 LEU A C     1 
ATOM   1778 O O     . LEU B 1 110 ? -39.071 0.264   83.713 1.00 28.09 ? 127 LEU A O     1 
ATOM   1779 C CB    . LEU B 1 110 ? -38.935 3.082   82.419 1.00 24.66 ? 127 LEU A CB    1 
ATOM   1780 C CG    . LEU B 1 110 ? -37.943 2.918   81.277 1.00 23.10 ? 127 LEU A CG    1 
ATOM   1781 C CD1   . LEU B 1 110 ? -38.624 2.876   79.905 1.00 22.55 ? 127 LEU A CD1   1 
ATOM   1782 C CD2   . LEU B 1 110 ? -36.978 4.077   81.353 1.00 22.10 ? 127 LEU A CD2   1 
ATOM   1783 N N     . SER B 1 111 ? -39.502 -0.097  81.531 1.00 26.13 ? 128 SER A N     1 
ATOM   1784 C CA    . SER B 1 111 ? -38.936 -1.437  81.525 1.00 26.96 ? 128 SER A CA    1 
ATOM   1785 C C     . SER B 1 111 ? -37.571 -1.457  82.196 1.00 27.23 ? 128 SER A C     1 
ATOM   1786 O O     . SER B 1 111 ? -36.700 -0.637  81.892 1.00 25.44 ? 128 SER A O     1 
ATOM   1787 C CB    . SER B 1 111 ? -38.824 -1.934  80.079 1.00 28.36 ? 128 SER A CB    1 
ATOM   1788 O OG    . SER B 1 111 ? -37.804 -2.916  79.966 1.00 33.35 ? 128 SER A OG    1 
ATOM   1789 N N     . ALA B 1 112 ? -37.396 -2.398  83.129 1.00 28.36 ? 129 ALA A N     1 
ATOM   1790 C CA    . ALA B 1 112 ? -36.111 -2.554  83.798 1.00 30.83 ? 129 ALA A CA    1 
ATOM   1791 C C     . ALA B 1 112 ? -34.980 -2.826  82.812 1.00 30.21 ? 129 ALA A C     1 
ATOM   1792 O O     . ALA B 1 112 ? -33.826 -2.500  83.105 1.00 31.13 ? 129 ALA A O     1 
ATOM   1793 C CB    . ALA B 1 112 ? -36.190 -3.674  84.834 1.00 34.71 ? 129 ALA A CB    1 
ATOM   1794 N N     . MET B 1 113 ? -35.281 -3.424  81.647 1.00 25.38 ? 130 MET A N     1 
ATOM   1795 C CA    . MET B 1 113 ? -34.237 -3.666  80.650 1.00 29.34 ? 130 MET A CA    1 
ATOM   1796 C C     . MET B 1 113 ? -33.674 -2.356  80.125 1.00 29.38 ? 130 MET A C     1 
ATOM   1797 O O     . MET B 1 113 ? -32.476 -2.256  79.830 1.00 31.82 ? 130 MET A O     1 
ATOM   1798 C CB    . MET B 1 113 ? -34.783 -4.508  79.496 1.00 26.06 ? 130 MET A CB    1 
ATOM   1799 C CG    . MET B 1 113 ? -35.151 -5.924  79.929 1.00 31.12 ? 130 MET A CG    1 
ATOM   1800 S SD    . MET B 1 113 ? -33.783 -6.766  80.759 1.00 41.96 ? 130 MET A SD    1 
ATOM   1801 C CE    . MET B 1 113 ? -32.597 -6.824  79.416 1.00 35.31 ? 130 MET A CE    1 
ATOM   1802 N N     . ILE B 1 114 ? -34.526 -1.341  80.007 1.00 27.56 ? 131 ILE A N     1 
ATOM   1803 C CA    . ILE B 1 114 ? -34.076 -0.026  79.561 1.00 25.95 ? 131 ILE A CA    1 
ATOM   1804 C C     . ILE B 1 114 ? -33.445 0.735   80.720 1.00 26.20 ? 131 ILE A C     1 
ATOM   1805 O O     . ILE B 1 114 ? -32.296 1.179   80.647 1.00 29.73 ? 131 ILE A O     1 
ATOM   1806 C CB    . ILE B 1 114 ? -35.254 0.751   78.943 1.00 24.10 ? 131 ILE A CB    1 
ATOM   1807 C CG1   . ILE B 1 114 ? -35.896 -0.067  77.830 1.00 25.69 ? 131 ILE A CG1   1 
ATOM   1808 C CG2   . ILE B 1 114 ? -34.800 2.115   78.405 1.00 22.26 ? 131 ILE A CG2   1 
ATOM   1809 C CD1   . ILE B 1 114 ? -34.923 -0.426  76.713 1.00 23.87 ? 131 ILE A CD1   1 
ATOM   1810 N N     . ARG B 1 115 ? -34.182 0.873   81.820 1.00 26.33 ? 132 ARG A N     1 
ATOM   1811 C CA    . ARG B 1 115 ? -33.660 1.611   82.965 1.00 28.23 ? 132 ARG A CA    1 
ATOM   1812 C C     . ARG B 1 115 ? -32.358 0.992   83.465 1.00 30.01 ? 132 ARG A C     1 
ATOM   1813 O O     . ARG B 1 115 ? -31.401 1.709   83.786 1.00 32.37 ? 132 ARG A O     1 
ATOM   1814 C CB    . ARG B 1 115 ? -34.738 1.676   84.061 1.00 28.81 ? 132 ARG A CB    1 
ATOM   1815 C CG    . ARG B 1 115 ? -34.267 2.172   85.413 1.00 37.20 ? 132 ARG A CG    1 
ATOM   1816 C CD    . ARG B 1 115 ? -34.721 3.594   85.759 1.00 36.19 ? 132 ARG A CD    1 
ATOM   1817 N NE    . ARG B 1 115 ? -36.070 3.997   85.361 1.00 34.41 ? 132 ARG A NE    1 
ATOM   1818 C CZ    . ARG B 1 115 ? -36.383 5.260   85.096 1.00 32.83 ? 132 ARG A CZ    1 
ATOM   1819 N NH1   . ARG B 1 115 ? -35.456 6.206   85.089 1.00 33.86 ? 132 ARG A NH1   1 
ATOM   1820 N NH2   . ARG B 1 115 ? -37.646 5.583   84.813 1.00 26.38 ? 132 ARG A NH2   1 
ATOM   1821 N N     . GLY B 1 116 ? -32.272 -0.340  83.460 1.00 25.75 ? 133 GLY A N     1 
ATOM   1822 C CA    . GLY B 1 116 ? -31.064 -1.017  83.912 1.00 32.69 ? 133 GLY A CA    1 
ATOM   1823 C C     . GLY B 1 116 ? -29.896 -0.943  82.950 1.00 33.02 ? 133 GLY A C     1 
ATOM   1824 O O     . GLY B 1 116 ? -28.765 -1.243  83.351 1.00 31.93 ? 133 GLY A O     1 
ATOM   1825 N N     . ALA B 1 117 ? -30.138 -0.554  81.698 1.00 29.66 ? 134 ALA A N     1 
ATOM   1826 C CA    . ALA B 1 117 ? -29.054 -0.363  80.746 1.00 33.87 ? 134 ALA A CA    1 
ATOM   1827 C C     . ALA B 1 117 ? -28.287 0.926   80.985 1.00 36.10 ? 134 ALA A C     1 
ATOM   1828 O O     . ALA B 1 117 ? -27.228 1.119   80.381 1.00 36.98 ? 134 ALA A O     1 
ATOM   1829 C CB    . ALA B 1 117 ? -29.600 -0.374  79.318 1.00 29.54 ? 134 ALA A CB    1 
ATOM   1830 N N     . ALA B 1 118 ? -28.793 1.806   81.845 1.00 35.12 ? 135 ALA A N     1 
ATOM   1831 C CA    . ALA B 1 118 ? -28.179 3.110   82.047 1.00 33.25 ? 135 ALA A CA    1 
ATOM   1832 C C     . ALA B 1 118 ? -26.853 2.968   82.781 1.00 36.85 ? 135 ALA A C     1 
ATOM   1833 O O     . ALA B 1 118 ? -26.770 2.301   83.815 1.00 38.36 ? 135 ALA A O     1 
ATOM   1834 C CB    . ALA B 1 118 ? -29.126 4.020   82.828 1.00 30.90 ? 135 ALA A CB    1 
ATOM   1835 N N     . ASP B 1 119 ? -25.806 3.583   82.232 1.00 38.20 ? 136 ASP A N     1 
ATOM   1836 C CA    . ASP B 1 119 ? -24.517 3.664   82.903 1.00 40.92 ? 136 ASP A CA    1 
ATOM   1837 C C     . ASP B 1 119 ? -24.142 5.100   83.229 1.00 38.96 ? 136 ASP A C     1 
ATOM   1838 O O     . ASP B 1 119 ? -23.043 5.339   83.746 1.00 41.42 ? 136 ASP A O     1 
ATOM   1839 C CB    . ASP B 1 119 ? -23.412 3.011   82.056 1.00 39.95 ? 136 ASP A CB    1 
ATOM   1840 C CG    . ASP B 1 119 ? -23.151 3.741   80.735 1.00 41.22 ? 136 ASP A CG    1 
ATOM   1841 O OD1   . ASP B 1 119 ? -23.880 4.704   80.403 1.00 36.95 ? 136 ASP A OD1   1 
ATOM   1842 O OD2   . ASP B 1 119 ? -22.214 3.335   80.010 1.00 44.28 ? 136 ASP A OD2   1 
ATOM   1843 N N     . GLY B 1 120 ? -25.018 6.060   82.930 1.00 37.98 ? 137 GLY A N     1 
ATOM   1844 C CA    . GLY B 1 120 ? -24.764 7.459   83.207 1.00 42.02 ? 137 GLY A CA    1 
ATOM   1845 C C     . GLY B 1 120 ? -23.826 8.154   82.248 1.00 42.81 ? 137 GLY A C     1 
ATOM   1846 O O     . GLY B 1 120 ? -23.591 9.360   82.401 1.00 43.34 ? 137 GLY A O     1 
ATOM   1847 N N     . SER B 1 121 ? -23.274 7.445   81.267 1.00 39.55 ? 138 SER A N     1 
ATOM   1848 C CA    . SER B 1 121 ? -22.370 8.096   80.330 1.00 40.96 ? 138 SER A CA    1 
ATOM   1849 C C     . SER B 1 121 ? -22.805 7.793   78.902 1.00 39.46 ? 138 SER A C     1 
ATOM   1850 O O     . SER B 1 121 ? -23.419 8.641   78.239 1.00 35.39 ? 138 SER A O     1 
ATOM   1851 C CB    . SER B 1 121 ? -20.927 7.652   80.582 1.00 46.00 ? 138 SER A CB    1 
ATOM   1852 O OG    . SER B 1 121 ? -20.057 8.144   79.573 1.00 55.37 ? 138 SER A OG    1 
ATOM   1853 N N     . ARG B 1 122 ? -22.527 6.571   78.436 1.00 35.60 ? 139 ARG A N     1 
ATOM   1854 C CA    . ARG B 1 122 ? -22.859 6.216   77.061 1.00 32.28 ? 139 ARG A CA    1 
ATOM   1855 C C     . ARG B 1 122 ? -24.343 5.976   76.877 1.00 27.23 ? 139 ARG A C     1 
ATOM   1856 O O     . ARG B 1 122 ? -24.870 6.182   75.782 1.00 30.05 ? 139 ARG A O     1 
ATOM   1857 C CB    . ARG B 1 122 ? -22.104 4.967   76.627 1.00 33.62 ? 139 ARG A CB    1 
ATOM   1858 C CG    . ARG B 1 122 ? -20.715 5.235   76.154 1.00 41.98 ? 139 ARG A CG    1 
ATOM   1859 C CD    . ARG B 1 122 ? -20.164 4.025   75.406 1.00 39.09 ? 139 ARG A CD    1 
ATOM   1860 N NE    . ARG B 1 122 ? -20.277 4.212   73.964 1.00 40.23 ? 139 ARG A NE    1 
ATOM   1861 C CZ    . ARG B 1 122 ? -19.851 5.277   73.299 1.00 34.49 ? 139 ARG A CZ    1 
ATOM   1862 N NH1   . ARG B 1 122 ? -19.164 6.239   73.892 1.00 34.08 ? 139 ARG A NH1   1 
ATOM   1863 N NH2   . ARG B 1 122 ? -20.117 5.380   72.000 1.00 34.18 ? 139 ARG A NH2   1 
ATOM   1864 N N     . PHE B 1 123 ? -25.014 5.487   77.911 1.00 27.03 ? 140 PHE A N     1 
ATOM   1865 C CA    . PHE B 1 123 ? -26.433 5.175   77.872 1.00 25.55 ? 140 PHE A CA    1 
ATOM   1866 C C     . PHE B 1 123 ? -27.045 5.901   79.060 1.00 29.52 ? 140 PHE A C     1 
ATOM   1867 O O     . PHE B 1 123 ? -26.788 5.544   80.215 1.00 28.92 ? 140 PHE A O     1 
ATOM   1868 C CB    . PHE B 1 123 ? -26.658 3.661   77.940 1.00 27.12 ? 140 PHE A CB    1 
ATOM   1869 C CG    . PHE B 1 123 ? -28.051 3.206   77.570 1.00 27.86 ? 140 PHE A CG    1 
ATOM   1870 C CD1   . PHE B 1 123 ? -29.168 3.687   78.238 1.00 27.09 ? 140 PHE A CD1   1 
ATOM   1871 C CD2   . PHE B 1 123 ? -28.238 2.277   76.557 1.00 26.62 ? 140 PHE A CD2   1 
ATOM   1872 C CE1   . PHE B 1 123 ? -30.436 3.241   77.908 1.00 29.49 ? 140 PHE A CE1   1 
ATOM   1873 C CE2   . PHE B 1 123 ? -29.512 1.835   76.215 1.00 23.57 ? 140 PHE A CE2   1 
ATOM   1874 C CZ    . PHE B 1 123 ? -30.607 2.314   76.894 1.00 28.71 ? 140 PHE A CZ    1 
ATOM   1875 N N     . GLN B 1 124 ? -27.803 6.946   78.777 1.00 24.82 ? 141 GLN A N     1 
ATOM   1876 C CA    . GLN B 1 124 ? -28.395 7.778   79.810 1.00 25.55 ? 141 GLN A CA    1 
ATOM   1877 C C     . GLN B 1 124 ? -29.899 7.706   79.662 1.00 25.49 ? 141 GLN A C     1 
ATOM   1878 O O     . GLN B 1 124 ? -30.423 7.663   78.543 1.00 24.59 ? 141 GLN A O     1 
ATOM   1879 C CB    . GLN B 1 124 ? -27.897 9.217   79.699 1.00 28.73 ? 141 GLN A CB    1 
ATOM   1880 C CG    . GLN B 1 124 ? -26.421 9.339   80.043 1.00 31.94 ? 141 GLN A CG    1 
ATOM   1881 C CD    . GLN B 1 124 ? -25.957 10.763  80.088 1.00 37.89 ? 141 GLN A CD    1 
ATOM   1882 O OE1   . GLN B 1 124 ? -26.536 11.595  80.790 1.00 38.88 ? 141 GLN A OE1   1 
ATOM   1883 N NE2   . GLN B 1 124 ? -24.914 11.065  79.325 1.00 36.98 ? 141 GLN A NE2   1 
ATOM   1884 N N     . VAL B 1 125 ? -30.584 7.630   80.798 1.00 22.85 ? 142 VAL A N     1 
ATOM   1885 C CA    . VAL B 1 125 ? -32.035 7.629   80.844 1.00 22.84 ? 142 VAL A CA    1 
ATOM   1886 C C     . VAL B 1 125 ? -32.431 8.806   81.714 1.00 26.78 ? 142 VAL A C     1 
ATOM   1887 O O     . VAL B 1 125 ? -32.036 8.868   82.887 1.00 26.16 ? 142 VAL A O     1 
ATOM   1888 C CB    . VAL B 1 125 ? -32.608 6.322   81.416 1.00 25.32 ? 142 VAL A CB    1 
ATOM   1889 C CG1   . VAL B 1 125 ? -34.129 6.397   81.448 1.00 26.35 ? 142 VAL A CG1   1 
ATOM   1890 C CG2   . VAL B 1 125 ? -32.122 5.101   80.609 1.00 25.56 ? 142 VAL A CG2   1 
ATOM   1891 N N     . TRP B 1 126 ? -33.181 9.739   81.139 1.00 23.01 ? 143 TRP A N     1 
ATOM   1892 C CA    . TRP B 1 126 ? -33.565 10.976  81.808 1.00 26.27 ? 143 TRP A CA    1 
ATOM   1893 C C     . TRP B 1 126 ? -35.076 10.994  81.951 1.00 28.69 ? 143 TRP A C     1 
ATOM   1894 O O     . TRP B 1 126 ? -35.799 10.839  80.957 1.00 23.22 ? 143 TRP A O     1 
ATOM   1895 C CB    . TRP B 1 126 ? -33.083 12.204  81.035 1.00 23.20 ? 143 TRP A CB    1 
ATOM   1896 C CG    . TRP B 1 126 ? -31.606 12.448  81.127 1.00 28.17 ? 143 TRP A CG    1 
ATOM   1897 C CD1   . TRP B 1 126 ? -30.663 11.608  81.642 1.00 31.81 ? 143 TRP A CD1   1 
ATOM   1898 C CD2   . TRP B 1 126 ? -30.902 13.605  80.665 1.00 30.42 ? 143 TRP A CD2   1 
ATOM   1899 N NE1   . TRP B 1 126 ? -29.412 12.175  81.543 1.00 32.33 ? 143 TRP A NE1   1 
ATOM   1900 C CE2   . TRP B 1 126 ? -29.532 13.398  80.937 1.00 33.02 ? 143 TRP A CE2   1 
ATOM   1901 C CE3   . TRP B 1 126 ? -31.296 14.796  80.045 1.00 30.01 ? 143 TRP A CE3   1 
ATOM   1902 C CZ2   . TRP B 1 126 ? -28.554 14.343  80.619 1.00 32.96 ? 143 TRP A CZ2   1 
ATOM   1903 C CZ3   . TRP B 1 126 ? -30.323 15.730  79.729 1.00 32.30 ? 143 TRP A CZ3   1 
ATOM   1904 C CH2   . TRP B 1 126 ? -28.968 15.498  80.017 1.00 31.08 ? 143 TRP A CH2   1 
ATOM   1905 N N     . ASP B 1 127 ? -35.543 11.162  83.190 1.00 26.00 ? 144 ASP A N     1 
ATOM   1906 C CA    . ASP B 1 127 ? -36.958 11.326  83.488 1.00 25.35 ? 144 ASP A CA    1 
ATOM   1907 C C     . ASP B 1 127 ? -37.311 12.802  83.349 1.00 28.88 ? 144 ASP A C     1 
ATOM   1908 O O     . ASP B 1 127 ? -36.572 13.669  83.829 1.00 32.64 ? 144 ASP A O     1 
ATOM   1909 C CB    . ASP B 1 127 ? -37.273 10.836  84.906 1.00 27.54 ? 144 ASP A CB    1 
ATOM   1910 C CG    . ASP B 1 127 ? -37.085 9.325   85.068 1.00 32.76 ? 144 ASP A CG    1 
ATOM   1911 O OD1   . ASP B 1 127 ? -37.894 8.551   84.518 1.00 32.49 ? 144 ASP A OD1   1 
ATOM   1912 O OD2   . ASP B 1 127 ? -36.130 8.911   85.762 1.00 36.94 ? 144 ASP A OD2   1 
ATOM   1913 N N     . TYR B 1 128 ? -38.428 13.094  82.679 1.00 24.85 ? 145 TYR A N     1 
ATOM   1914 C CA    . TYR B 1 128 ? -38.734 14.487  82.360 1.00 30.29 ? 145 TYR A CA    1 
ATOM   1915 C C     . TYR B 1 128 ? -40.240 14.713  82.262 1.00 29.48 ? 145 TYR A C     1 
ATOM   1916 O O     . TYR B 1 128 ? -41.032 13.772  82.192 1.00 25.64 ? 145 TYR A O     1 
ATOM   1917 C CB    . TYR B 1 128 ? -38.037 14.924  81.068 1.00 26.93 ? 145 TYR A CB    1 
ATOM   1918 C CG    . TYR B 1 128 ? -38.727 14.472  79.814 1.00 24.10 ? 145 TYR A CG    1 
ATOM   1919 C CD1   . TYR B 1 128 ? -38.604 13.159  79.374 1.00 24.63 ? 145 TYR A CD1   1 
ATOM   1920 C CD2   . TYR B 1 128 ? -39.489 15.346  79.065 1.00 23.80 ? 145 TYR A CD2   1 
ATOM   1921 C CE1   . TYR B 1 128 ? -39.246 12.731  78.234 1.00 23.45 ? 145 TYR A CE1   1 
ATOM   1922 C CE2   . TYR B 1 128 ? -40.132 14.937  77.922 1.00 26.91 ? 145 TYR A CE2   1 
ATOM   1923 C CZ    . TYR B 1 128 ? -39.992 13.620  77.499 1.00 25.17 ? 145 TYR A CZ    1 
ATOM   1924 O OH    . TYR B 1 128 ? -40.636 13.203  76.368 1.00 24.67 ? 145 TYR A OH    1 
ATOM   1925 N N     . GLU B 1 129 ? -40.625 15.993  82.293 1.00 27.70 ? 146 GLU A N     1 
ATOM   1926 C CA    . GLU B 1 129 ? -41.976 16.450  81.999 1.00 29.77 ? 146 GLU A CA    1 
ATOM   1927 C C     . GLU B 1 129 ? -42.004 17.129  80.636 1.00 30.80 ? 146 GLU A C     1 
ATOM   1928 O O     . GLU B 1 129 ? -41.031 17.766  80.226 1.00 30.39 ? 146 GLU A O     1 
ATOM   1929 C CB    . GLU B 1 129 ? -42.487 17.421  83.077 1.00 37.78 ? 146 GLU A CB    1 
ATOM   1930 C CG    . GLU B 1 129 ? -41.781 18.770  83.051 1.00 47.38 ? 146 GLU A CG    1 
ATOM   1931 C CD    . GLU B 1 129 ? -42.668 19.940  82.627 1.00 50.21 ? 146 GLU A CD    1 
ATOM   1932 O OE1   . GLU B 1 129 ? -43.794 19.710  82.119 1.00 61.35 ? 146 GLU A OE1   1 
ATOM   1933 O OE2   . GLU B 1 129 ? -42.221 21.103  82.801 1.00 56.57 ? 146 GLU A OE2   1 
ATOM   1934 N N     . GLU B 1 130 ? -43.139 16.996  79.937 1.00 30.70 ? 147 GLU A N     1 
ATOM   1935 C CA    . GLU B 1 130 ? -43.198 17.372  78.524 1.00 29.80 ? 147 GLU A CA    1 
ATOM   1936 C C     . GLU B 1 130 ? -42.761 18.815  78.292 1.00 32.45 ? 147 GLU A C     1 
ATOM   1937 O O     . GLU B 1 130 ? -42.113 19.117  77.281 1.00 31.31 ? 147 GLU A O     1 
ATOM   1938 C CB    . GLU B 1 130 ? -44.607 17.169  77.966 1.00 33.18 ? 147 GLU A CB    1 
ATOM   1939 C CG    . GLU B 1 130 ? -44.733 15.967  77.035 1.00 36.04 ? 147 GLU A CG    1 
ATOM   1940 C CD    . GLU B 1 130 ? -46.047 15.922  76.285 0.42 37.97 ? 147 GLU A CD    1 
ATOM   1941 O OE1   . GLU B 1 130 ? -46.646 14.831  76.197 0.47 41.10 ? 147 GLU A OE1   1 
ATOM   1942 O OE2   . GLU B 1 130 ? -46.464 16.974  75.756 0.49 42.52 ? 147 GLU A OE2   1 
ATOM   1943 N N     . GLY B 1 131 ? -43.134 19.726  79.195 1.00 28.70 ? 148 GLY A N     1 
ATOM   1944 C CA    . GLY B 1 131 ? -42.837 21.130  78.974 1.00 29.66 ? 148 GLY A CA    1 
ATOM   1945 C C     . GLY B 1 131 ? -41.362 21.472  78.931 1.00 30.35 ? 148 GLY A C     1 
ATOM   1946 O O     . GLY B 1 131 ? -40.996 22.516  78.376 1.00 29.33 ? 148 GLY A O     1 
ATOM   1947 N N     . GLU B 1 132 ? -40.503 20.626  79.497 1.00 29.22 ? 149 GLU A N     1 
ATOM   1948 C CA    . GLU B 1 132 ? -39.079 20.921  79.615 1.00 28.69 ? 149 GLU A CA    1 
ATOM   1949 C C     . GLU B 1 132 ? -38.224 20.145  78.621 1.00 26.25 ? 149 GLU A C     1 
ATOM   1950 O O     . GLU B 1 132 ? -36.999 20.147  78.752 1.00 23.64 ? 149 GLU A O     1 
ATOM   1951 C CB    . GLU B 1 132 ? -38.593 20.635  81.047 1.00 30.56 ? 149 GLU A CB    1 
ATOM   1952 C CG    . GLU B 1 132 ? -38.605 19.153  81.362 1.00 34.13 ? 149 GLU A CG    1 
ATOM   1953 C CD    . GLU B 1 132 ? -38.133 18.800  82.757 1.00 37.31 ? 149 GLU A CD    1 
ATOM   1954 O OE1   . GLU B 1 132 ? -37.355 19.580  83.354 1.00 39.98 ? 149 GLU A OE1   1 
ATOM   1955 O OE2   . GLU B 1 132 ? -38.543 17.725  83.248 1.00 33.26 ? 149 GLU A OE2   1 
ATOM   1956 N N     . VAL B 1 133 ? -38.823 19.490  77.624 1.00 23.82 ? 150 VAL A N     1 
ATOM   1957 C CA    . VAL B 1 133 ? -38.022 18.581  76.803 1.00 24.53 ? 150 VAL A CA    1 
ATOM   1958 C C     . VAL B 1 133 ? -36.952 19.337  76.011 1.00 23.84 ? 150 VAL A C     1 
ATOM   1959 O O     . VAL B 1 133 ? -35.831 18.849  75.850 1.00 25.77 ? 150 VAL A O     1 
ATOM   1960 C CB    . VAL B 1 133 ? -38.920 17.712  75.895 1.00 27.02 ? 150 VAL A CB    1 
ATOM   1961 C CG1   . VAL B 1 133 ? -39.526 18.510  74.736 1.00 25.16 ? 150 VAL A CG1   1 
ATOM   1962 C CG2   . VAL B 1 133 ? -38.109 16.526  75.357 1.00 25.17 ? 150 VAL A CG2   1 
ATOM   1963 N N     . GLU B 1 134 ? -37.261 20.534  75.509 1.00 23.18 ? 151 GLU A N     1 
ATOM   1964 C CA    . GLU B 1 134 ? -36.242 21.293  74.787 1.00 21.44 ? 151 GLU A CA    1 
ATOM   1965 C C     . GLU B 1 134 ? -35.083 21.666  75.696 1.00 20.81 ? 151 GLU A C     1 
ATOM   1966 O O     . GLU B 1 134 ? -33.919 21.616  75.284 1.00 22.87 ? 151 GLU A O     1 
ATOM   1967 C CB    . GLU B 1 134 ? -36.858 22.547  74.167 1.00 26.28 ? 151 GLU A CB    1 
ATOM   1968 C CG    . GLU B 1 134 ? -37.772 22.241  73.017 1.00 23.85 ? 151 GLU A CG    1 
ATOM   1969 C CD    . GLU B 1 134 ? -39.198 22.003  73.443 1.00 25.99 ? 151 GLU A CD    1 
ATOM   1970 O OE1   . GLU B 1 134 ? -39.474 21.940  74.665 1.00 28.27 ? 151 GLU A OE1   1 
ATOM   1971 O OE2   . GLU B 1 134 ? -40.043 21.856  72.542 1.00 26.43 ? 151 GLU A OE2   1 
ATOM   1972 N N     . ALA B 1 135 ? -35.382 22.020  76.944 1.00 22.32 ? 152 ALA A N     1 
ATOM   1973 C CA    . ALA B 1 135 ? -34.333 22.387  77.879 1.00 22.79 ? 152 ALA A CA    1 
ATOM   1974 C C     . ALA B 1 135 ? -33.434 21.195  78.185 1.00 25.51 ? 152 ALA A C     1 
ATOM   1975 O O     . ALA B 1 135 ? -32.212 21.344  78.260 1.00 24.46 ? 152 ALA A O     1 
ATOM   1976 C CB    . ALA B 1 135 ? -34.949 22.943  79.164 1.00 23.04 ? 152 ALA A CB    1 
ATOM   1977 N N     . LEU B 1 136 ? -34.020 20.008  78.364 1.00 25.83 ? 153 LEU A N     1 
ATOM   1978 C CA    . LEU B 1 136 ? -33.194 18.830  78.609 1.00 28.17 ? 153 LEU A CA    1 
ATOM   1979 C C     . LEU B 1 136 ? -32.320 18.506  77.410 1.00 23.73 ? 153 LEU A C     1 
ATOM   1980 O O     . LEU B 1 136 ? -31.161 18.112  77.570 1.00 26.69 ? 153 LEU A O     1 
ATOM   1981 C CB    . LEU B 1 136 ? -34.050 17.625  78.986 1.00 28.30 ? 153 LEU A CB    1 
ATOM   1982 C CG    . LEU B 1 136 ? -34.822 17.746  80.285 1.00 34.79 ? 153 LEU A CG    1 
ATOM   1983 C CD1   . LEU B 1 136 ? -35.075 16.356  80.816 1.00 34.72 ? 153 LEU A CD1   1 
ATOM   1984 C CD2   . LEU B 1 136 ? -34.039 18.560  81.304 1.00 38.14 ? 153 LEU A CD2   1 
ATOM   1985 N N     . LEU B 1 137 ? -32.852 18.679  76.201 1.00 22.61 ? 154 LEU A N     1 
ATOM   1986 C CA    . LEU B 1 137 ? -32.036 18.466  75.008 1.00 22.06 ? 154 LEU A CA    1 
ATOM   1987 C C     . LEU B 1 137 ? -30.917 19.503  74.931 1.00 25.78 ? 154 LEU A C     1 
ATOM   1988 O O     . LEU B 1 137 ? -29.774 19.177  74.595 1.00 22.23 ? 154 LEU A O     1 
ATOM   1989 C CB    . LEU B 1 137 ? -32.919 18.515  73.756 1.00 22.07 ? 154 LEU A CB    1 
ATOM   1990 C CG    . LEU B 1 137 ? -33.912 17.357  73.583 1.00 20.96 ? 154 LEU A CG    1 
ATOM   1991 C CD1   . LEU B 1 137 ? -34.844 17.577  72.375 1.00 21.91 ? 154 LEU A CD1   1 
ATOM   1992 C CD2   . LEU B 1 137 ? -33.195 15.999  73.479 1.00 20.83 ? 154 LEU A CD2   1 
ATOM   1993 N N     . ASP B 1 138 ? -31.222 20.758  75.258 1.00 24.11 ? 155 ASP A N     1 
ATOM   1994 C CA    . ASP B 1 138 ? -30.169 21.769  75.339 1.00 25.85 ? 155 ASP A CA    1 
ATOM   1995 C C     . ASP B 1 138 ? -29.098 21.380  76.351 1.00 26.58 ? 155 ASP A C     1 
ATOM   1996 O O     . ASP B 1 138 ? -27.900 21.585  76.108 1.00 24.34 ? 155 ASP A O     1 
ATOM   1997 C CB    . ASP B 1 138 ? -30.752 23.128  75.722 1.00 27.30 ? 155 ASP A CB    1 
ATOM   1998 C CG    . ASP B 1 138 ? -31.656 23.714  74.651 1.00 27.53 ? 155 ASP A CG    1 
ATOM   1999 O OD1   . ASP B 1 138 ? -31.655 23.235  73.494 1.00 27.29 ? 155 ASP A OD1   1 
ATOM   2000 O OD2   . ASP B 1 138 ? -32.344 24.698  74.978 1.00 29.60 ? 155 ASP A OD2   1 
ATOM   2001 N N     . ARG B 1 139 ? -29.516 20.835  77.499 1.00 27.53 ? 156 ARG A N     1 
ATOM   2002 C CA    . ARG B 1 139 ? -28.558 20.393  78.510 1.00 30.52 ? 156 ARG A CA    1 
ATOM   2003 C C     . ARG B 1 139 ? -27.671 19.288  77.962 1.00 31.12 ? 156 ARG A C     1 
ATOM   2004 O O     . ARG B 1 139 ? -26.441 19.347  78.064 1.00 33.55 ? 156 ARG A O     1 
ATOM   2005 C CB    . ARG B 1 139 ? -29.290 19.904  79.762 1.00 31.84 ? 156 ARG A CB    1 
ATOM   2006 C CG    . ARG B 1 139 ? -28.348 19.401  80.855 1.00 36.36 ? 156 ARG A CG    1 
ATOM   2007 C CD    . ARG B 1 139 ? -29.091 18.981  82.119 1.00 41.75 ? 156 ARG A CD    1 
ATOM   2008 N NE    . ARG B 1 139 ? -29.994 20.015  82.614 1.00 50.55 ? 156 ARG A NE    1 
ATOM   2009 C CZ    . ARG B 1 139 ? -29.647 20.964  83.470 1.00 56.63 ? 156 ARG A CZ    1 
ATOM   2010 N NH1   . ARG B 1 139 ? -28.414 21.051  83.937 1.00 60.90 ? 156 ARG A NH1   1 
ATOM   2011 N NH2   . ARG B 1 139 ? -30.559 21.848  83.865 1.00 58.36 ? 156 ARG A NH2   1 
ATOM   2012 N N     . TYR B 1 140 ? -28.284 18.270  77.367 1.00 27.30 ? 157 TYR A N     1 
ATOM   2013 C CA    . TYR B 1 140 ? -27.525 17.117  76.898 1.00 25.81 ? 157 TYR A CA    1 
ATOM   2014 C C     . TYR B 1 140 ? -26.504 17.508  75.836 1.00 29.32 ? 157 TYR A C     1 
ATOM   2015 O O     . TYR B 1 140 ? -25.354 17.051  75.865 1.00 27.24 ? 157 TYR A O     1 
ATOM   2016 C CB    . TYR B 1 140 ? -28.469 16.059  76.344 1.00 27.30 ? 157 TYR A CB    1 
ATOM   2017 C CG    . TYR B 1 140 ? -27.746 14.782  75.990 1.00 25.72 ? 157 TYR A CG    1 
ATOM   2018 C CD1   . TYR B 1 140 ? -27.479 13.827  76.956 1.00 30.84 ? 157 TYR A CD1   1 
ATOM   2019 C CD2   . TYR B 1 140 ? -27.306 14.550  74.695 1.00 26.33 ? 157 TYR A CD2   1 
ATOM   2020 C CE1   . TYR B 1 140 ? -26.808 12.668  76.644 1.00 28.97 ? 157 TYR A CE1   1 
ATOM   2021 C CE2   . TYR B 1 140 ? -26.629 13.383  74.364 1.00 31.21 ? 157 TYR A CE2   1 
ATOM   2022 C CZ    . TYR B 1 140 ? -26.391 12.444  75.343 1.00 30.08 ? 157 TYR A CZ    1 
ATOM   2023 O OH    . TYR B 1 140 ? -25.726 11.281  75.029 1.00 28.51 ? 157 TYR A OH    1 
ATOM   2024 N N     . PHE B 1 141 ? -26.912 18.334  74.877 1.00 27.23 ? 158 PHE A N     1 
ATOM   2025 C CA    . PHE B 1 141 ? -26.085 18.645  73.717 1.00 30.15 ? 158 PHE A CA    1 
ATOM   2026 C C     . PHE B 1 141 ? -25.265 19.912  73.888 1.00 35.48 ? 158 PHE A C     1 
ATOM   2027 O O     . PHE B 1 141 ? -24.669 20.380  72.914 1.00 38.07 ? 158 PHE A O     1 
ATOM   2028 C CB    . PHE B 1 141 ? -26.962 18.760  72.474 1.00 26.94 ? 158 PHE A CB    1 
ATOM   2029 C CG    . PHE B 1 141 ? -27.479 17.440  71.982 1.00 29.24 ? 158 PHE A CG    1 
ATOM   2030 C CD1   . PHE B 1 141 ? -26.649 16.571  71.277 1.00 27.98 ? 158 PHE A CD1   1 
ATOM   2031 C CD2   . PHE B 1 141 ? -28.767 17.036  72.288 1.00 27.59 ? 158 PHE A CD2   1 
ATOM   2032 C CE1   . PHE B 1 141 ? -27.121 15.343  70.836 1.00 25.65 ? 158 PHE A CE1   1 
ATOM   2033 C CE2   . PHE B 1 141 ? -29.245 15.810  71.861 1.00 28.24 ? 158 PHE A CE2   1 
ATOM   2034 C CZ    . PHE B 1 141 ? -28.413 14.955  71.133 1.00 26.72 ? 158 PHE A CZ    1 
ATOM   2035 N N     . GLU B 1 142 ? -25.225 20.478  75.090 1.00 37.64 ? 159 GLU A N     1 
ATOM   2036 C CA    . GLU B 1 142 ? -24.359 21.619  75.367 1.00 40.70 ? 159 GLU A CA    1 
ATOM   2037 C C     . GLU B 1 142 ? -22.904 21.295  75.017 1.00 48.42 ? 159 GLU A C     1 
ATOM   2038 O O     . GLU B 1 142 ? -22.182 22.136  74.467 1.00 59.99 ? 159 GLU A O     1 
ATOM   2039 C CB    . GLU B 1 142 ? -24.459 22.015  76.840 1.00 42.73 ? 159 GLU A CB    1 
ATOM   2040 C CG    . GLU B 1 142 ? -23.894 23.392  77.134 1.00 49.56 ? 159 GLU A CG    1 
ATOM   2041 C CD    . GLU B 1 142 ? -23.529 23.570  78.599 0.10 53.54 ? 159 GLU A CD    1 
ATOM   2042 O OE1   . GLU B 1 142 ? -23.848 22.672  79.409 0.80 52.81 ? 159 GLU A OE1   1 
ATOM   2043 O OE2   . GLU B 1 142 ? -22.936 24.614  78.944 0.75 55.13 ? 159 GLU A OE2   1 
ATOM   2044 N N     . GLY C 1 1   ? -24.828 -27.178 79.590 1.00 61.88 ? 18  GLY B N     1 
ATOM   2045 C CA    . GLY C 1 1   ? -24.854 -27.277 78.120 1.00 64.57 ? 18  GLY B CA    1 
ATOM   2046 C C     . GLY C 1 1   ? -25.309 -28.658 77.710 1.00 60.88 ? 18  GLY B C     1 
ATOM   2047 O O     . GLY C 1 1   ? -25.164 -29.010 76.525 1.00 64.55 ? 18  GLY B O     1 
ATOM   2048 N N     . MET C 1 2   ? -25.842 -29.417 78.666 1.00 57.17 ? 19  MET B N     1 
ATOM   2049 C CA    . MET C 1 2   ? -26.346 -30.781 78.374 1.00 56.99 ? 19  MET B CA    1 
ATOM   2050 C C     . MET C 1 2   ? -27.487 -30.657 77.362 1.00 52.05 ? 19  MET B C     1 
ATOM   2051 O O     . MET C 1 2   ? -27.519 -31.430 76.389 1.00 52.08 ? 19  MET B O     1 
ATOM   2052 C CB    . MET C 1 2   ? -26.878 -31.424 79.656 1.00 59.02 ? 19  MET B CB    1 
ATOM   2053 C CG    . MET C 1 2   ? -27.371 -32.837 79.466 1.00 60.87 ? 19  MET B CG    1 
ATOM   2054 S SD    . MET C 1 2   ? -27.743 -33.596 81.060 1.00 66.74 ? 19  MET B SD    1 
ATOM   2055 C CE    . MET C 1 2   ? -28.168 -32.150 82.030 1.00 67.54 ? 19  MET B CE    1 
ATOM   2056 N N     . ARG C 1 3   ? -28.362 -29.679 77.581 1.00 40.65 ? 20  ARG B N     1 
ATOM   2057 C CA    . ARG C 1 3   ? -29.516 -29.449 76.683 1.00 38.24 ? 20  ARG B CA    1 
ATOM   2058 C C     . ARG C 1 3   ? -29.403 -28.048 76.092 1.00 31.95 ? 20  ARG B C     1 
ATOM   2059 O O     . ARG C 1 3   ? -28.658 -27.230 76.629 1.00 33.18 ? 20  ARG B O     1 
ATOM   2060 C CB    . ARG C 1 3   ? -30.829 -29.444 77.466 1.00 30.00 ? 20  ARG B CB    1 
ATOM   2061 C CG    . ARG C 1 3   ? -31.018 -30.597 78.435 1.00 30.00 ? 20  ARG B CG    1 
ATOM   2062 C CD    . ARG C 1 3   ? -32.501 -30.777 78.661 1.00 30.00 ? 20  ARG B CD    1 
ATOM   2063 N NE    . ARG C 1 3   ? -33.159 -31.118 77.416 1.00 30.00 ? 20  ARG B NE    1 
ATOM   2064 C CZ    . ARG C 1 3   ? -34.453 -30.988 77.191 1.00 30.00 ? 20  ARG B CZ    1 
ATOM   2065 N NH1   . ARG C 1 3   ? -35.239 -30.494 78.129 1.00 30.00 ? 20  ARG B NH1   1 
ATOM   2066 N NH2   . ARG C 1 3   ? -34.954 -31.340 76.026 1.00 30.00 ? 20  ARG B NH2   1 
ATOM   2067 N N     . PRO C 1 4   ? -30.112 -27.745 74.993 1.00 30.68 ? 21  PRO B N     1 
ATOM   2068 C CA    . PRO C 1 4   ? -30.118 -26.394 74.456 1.00 28.96 ? 21  PRO B CA    1 
ATOM   2069 C C     . PRO C 1 4   ? -30.706 -25.439 75.508 1.00 27.32 ? 21  PRO B C     1 
ATOM   2070 O O     . PRO C 1 4   ? -31.663 -25.786 76.158 1.00 24.30 ? 21  PRO B O     1 
ATOM   2071 C CB    . PRO C 1 4   ? -31.116 -26.500 73.295 1.00 30.37 ? 21  PRO B CB    1 
ATOM   2072 C CG    . PRO C 1 4   ? -31.063 -27.951 72.891 1.00 32.47 ? 21  PRO B CG    1 
ATOM   2073 C CD    . PRO C 1 4   ? -30.877 -28.691 74.194 1.00 30.81 ? 21  PRO B CD    1 
ATOM   2074 N N     . ALA C 1 5   ? -30.120 -24.249 75.628 1.00 24.04 ? 22  ALA B N     1 
ATOM   2075 C CA    . ALA C 1 5   ? -30.607 -23.235 76.585 1.00 26.13 ? 22  ALA B CA    1 
ATOM   2076 C C     . ALA C 1 5   ? -31.590 -22.342 75.832 1.00 23.40 ? 22  ALA B C     1 
ATOM   2077 O O     . ALA C 1 5   ? -31.182 -21.737 74.847 1.00 22.23 ? 22  ALA B O     1 
ATOM   2078 C CB    . ALA C 1 5   ? -29.451 -22.439 77.126 1.00 28.01 ? 22  ALA B CB    1 
ATOM   2079 N N     . LEU C 1 6   ? -32.835 -22.293 76.299 1.00 22.82 ? 23  LEU B N     1 
ATOM   2080 C CA    . LEU C 1 6   ? -33.887 -21.505 75.615 1.00 19.41 ? 23  LEU B CA    1 
ATOM   2081 C C     . LEU C 1 6   ? -34.292 -20.338 76.507 1.00 24.28 ? 23  LEU B C     1 
ATOM   2082 O O     . LEU C 1 6   ? -34.771 -20.572 77.618 1.00 27.47 ? 23  LEU B O     1 
ATOM   2083 C CB    . LEU C 1 6   ? -35.083 -22.410 75.311 1.00 19.24 ? 23  LEU B CB    1 
ATOM   2084 C CG    . LEU C 1 6   ? -34.739 -23.749 74.665 1.00 21.15 ? 23  LEU B CG    1 
ATOM   2085 C CD1   . LEU C 1 6   ? -35.985 -24.585 74.442 1.00 20.01 ? 23  LEU B CD1   1 
ATOM   2086 C CD2   . LEU C 1 6   ? -33.994 -23.546 73.362 1.00 22.87 ? 23  LEU B CD2   1 
ATOM   2087 N N     . TYR C 1 7   ? -34.063 -19.130 76.016 1.00 20.89 ? 24  TYR B N     1 
ATOM   2088 C CA    . TYR C 1 7   ? -34.416 -17.920 76.742 1.00 21.14 ? 24  TYR B CA    1 
ATOM   2089 C C     . TYR C 1 7   ? -35.739 -17.399 76.210 1.00 21.77 ? 24  TYR B C     1 
ATOM   2090 O O     . TYR C 1 7   ? -35.848 -17.080 75.024 1.00 22.51 ? 24  TYR B O     1 
ATOM   2091 C CB    . TYR C 1 7   ? -33.323 -16.859 76.589 1.00 20.88 ? 24  TYR B CB    1 
ATOM   2092 C CG    . TYR C 1 7   ? -33.598 -15.594 77.359 1.00 20.90 ? 24  TYR B CG    1 
ATOM   2093 C CD1   . TYR C 1 7   ? -33.344 -15.510 78.727 1.00 29.81 ? 24  TYR B CD1   1 
ATOM   2094 C CD2   . TYR C 1 7   ? -34.115 -14.474 76.718 1.00 25.15 ? 24  TYR B CD2   1 
ATOM   2095 C CE1   . TYR C 1 7   ? -33.609 -14.336 79.434 1.00 31.68 ? 24  TYR B CE1   1 
ATOM   2096 C CE2   . TYR C 1 7   ? -34.373 -13.296 77.413 1.00 27.38 ? 24  TYR B CE2   1 
ATOM   2097 C CZ    . TYR C 1 7   ? -34.112 -13.229 78.759 1.00 31.62 ? 24  TYR B CZ    1 
ATOM   2098 O OH    . TYR C 1 7   ? -34.378 -12.062 79.444 1.00 36.09 ? 24  TYR B OH    1 
ATOM   2099 N N     . PHE C 1 8   ? -36.731 -17.298 77.083 1.00 18.32 ? 25  PHE B N     1 
ATOM   2100 C CA    . PHE C 1 8   ? -38.070 -16.833 76.708 1.00 20.48 ? 25  PHE B CA    1 
ATOM   2101 C C     . PHE C 1 8   ? -38.245 -15.393 77.204 1.00 23.69 ? 25  PHE B C     1 
ATOM   2102 O O     . PHE C 1 8   ? -38.243 -15.153 78.416 1.00 21.78 ? 25  PHE B O     1 
ATOM   2103 C CB    . PHE C 1 8   ? -39.121 -17.768 77.302 1.00 20.13 ? 25  PHE B CB    1 
ATOM   2104 C CG    . PHE C 1 8   ? -40.524 -17.421 76.929 1.00 21.61 ? 25  PHE B CG    1 
ATOM   2105 C CD1   . PHE C 1 8   ? -40.819 -16.944 75.664 1.00 21.19 ? 25  PHE B CD1   1 
ATOM   2106 C CD2   . PHE C 1 8   ? -41.558 -17.582 77.841 1.00 22.05 ? 25  PHE B CD2   1 
ATOM   2107 C CE1   . PHE C 1 8   ? -42.117 -16.623 75.305 1.00 22.21 ? 25  PHE B CE1   1 
ATOM   2108 C CE2   . PHE C 1 8   ? -42.877 -17.254 77.487 1.00 22.54 ? 25  PHE B CE2   1 
ATOM   2109 C CZ    . PHE C 1 8   ? -43.150 -16.775 76.229 1.00 22.40 ? 25  PHE B CZ    1 
ATOM   2110 N N     . CYS C 1 9   ? -38.374 -14.440 76.264 1.00 22.07 ? 26  CYS B N     1 
ATOM   2111 C CA    . CYS C 1 9   ? -38.392 -13.006 76.556 1.00 29.70 ? 26  CYS B CA    1 
ATOM   2112 C C     . CYS C 1 9   ? -39.735 -12.557 77.081 1.00 30.89 ? 26  CYS B C     1 
ATOM   2113 O O     . CYS C 1 9   ? -40.785 -13.123 76.765 1.00 34.11 ? 26  CYS B O     1 
ATOM   2114 C CB    . CYS C 1 9   ? -38.143 -12.114 75.329 1.00 22.93 ? 26  CYS B CB    1 
ATOM   2115 S SG    . CYS C 1 9   ? -36.733 -12.394 74.321 1.00 37.64 ? 26  CYS B SG    1 
ATOM   2116 N N     . GLY C 1 10  ? -39.686 -11.446 77.805 1.00 38.40 ? 27  GLY B N     1 
ATOM   2117 C CA    . GLY C 1 10  ? -40.871 -10.770 78.270 1.00 39.71 ? 27  GLY B CA    1 
ATOM   2118 C C     . GLY C 1 10  ? -41.313 -11.264 79.627 1.00 42.55 ? 27  GLY B C     1 
ATOM   2119 O O     . GLY C 1 10  ? -40.788 -12.226 80.191 1.00 41.29 ? 27  GLY B O     1 
ATOM   2120 N N     . SER C 1 11  ? -42.303 -10.574 80.160 1.00 50.12 ? 28  SER B N     1 
ATOM   2121 C CA    . SER C 1 11  ? -42.921 -10.956 81.412 1.00 51.69 ? 28  SER B CA    1 
ATOM   2122 C C     . SER C 1 11  ? -44.394 -11.205 81.157 1.00 53.98 ? 28  SER B C     1 
ATOM   2123 O O     . SER C 1 11  ? -44.998 -10.594 80.271 1.00 52.34 ? 28  SER B O     1 
ATOM   2124 C CB    . SER C 1 11  ? -42.735 -9.881  82.480 1.00 60.54 ? 28  SER B CB    1 
ATOM   2125 O OG    . SER C 1 11  ? -42.628 -8.601  81.881 1.00 75.09 ? 28  SER B OG    1 
ATOM   2126 N N     . ILE C 1 12  ? -44.954 -12.138 81.927 1.00 49.61 ? 29  ILE B N     1 
ATOM   2127 C CA    . ILE C 1 12  ? -46.371 -12.424 81.816 1.00 46.43 ? 29  ILE B CA    1 
ATOM   2128 C C     . ILE C 1 12  ? -47.150 -11.163 82.161 1.00 53.12 ? 29  ILE B C     1 
ATOM   2129 O O     . ILE C 1 12  ? -46.782 -10.408 83.073 1.00 54.68 ? 29  ILE B O     1 
ATOM   2130 C CB    . ILE C 1 12  ? -46.728 -13.615 82.719 1.00 41.95 ? 29  ILE B CB    1 
ATOM   2131 C CG1   . ILE C 1 12  ? -48.196 -13.985 82.576 1.00 43.61 ? 29  ILE B CG1   1 
ATOM   2132 C CG2   . ILE C 1 12  ? -46.388 -13.324 84.172 1.00 52.14 ? 29  ILE B CG2   1 
ATOM   2133 C CD1   . ILE C 1 12  ? -48.456 -15.397 82.999 1.00 40.15 ? 29  ILE B CD1   1 
ATOM   2134 N N     . ARG C 1 13  ? -48.196 -10.896 81.389 1.00 52.02 ? 30  ARG B N     1 
ATOM   2135 C CA    . ARG C 1 13  ? -48.991 -9.687  81.552 1.00 53.88 ? 30  ARG B CA    1 
ATOM   2136 C C     . ARG C 1 13  ? -50.288 -9.874  80.779 1.00 56.76 ? 30  ARG B C     1 
ATOM   2137 O O     . ARG C 1 13  ? -50.643 -10.991 80.385 1.00 52.28 ? 30  ARG B O     1 
ATOM   2138 C CB    . ARG C 1 13  ? -48.250 -8.449  81.038 1.00 61.38 ? 30  ARG B CB    1 
ATOM   2139 C CG    . ARG C 1 13  ? -47.586 -8.680  79.696 1.00 61.11 ? 30  ARG B CG    1 
ATOM   2140 C CD    . ARG C 1 13  ? -47.204 -7.396  78.980 1.00 68.25 ? 30  ARG B CD    1 
ATOM   2141 N NE    . ARG C 1 13  ? -46.600 -7.724  77.695 1.00 70.22 ? 30  ARG B NE    1 
ATOM   2142 C CZ    . ARG C 1 13  ? -45.446 -7.244  77.251 1.00 73.21 ? 30  ARG B CZ    1 
ATOM   2143 N NH1   . ARG C 1 13  ? -44.819 -6.261  77.878 1.00 71.19 ? 30  ARG B NH1   1 
ATOM   2144 N NH2   . ARG C 1 13  ? -44.912 -7.761  76.148 1.00 75.21 ? 30  ARG B NH2   1 
ATOM   2145 N N     . GLY C 1 14  ? -50.986 -8.762  80.544 1.00 57.03 ? 31  GLY B N     1 
ATOM   2146 C CA    . GLY C 1 14  ? -52.134 -8.735  79.668 1.00 53.06 ? 31  GLY B CA    1 
ATOM   2147 C C     . GLY C 1 14  ? -53.325 -9.507  80.211 1.00 52.14 ? 31  GLY B C     1 
ATOM   2148 O O     . GLY C 1 14  ? -53.474 -9.748  81.420 1.00 50.07 ? 31  GLY B O     1 
ATOM   2149 N N     . GLY C 1 15  ? -54.172 -9.959  79.285 1.00 48.65 ? 32  GLY B N     1 
ATOM   2150 C CA    . GLY C 1 15  ? -55.399 -10.687 79.653 1.00 48.82 ? 32  GLY B CA    1 
ATOM   2151 C C     . GLY C 1 15  ? -55.162 -12.139 80.030 1.00 47.91 ? 32  GLY B C     1 
ATOM   2152 O O     . GLY C 1 15  ? -54.008 -12.613 79.994 1.00 47.16 ? 32  GLY B O     1 
ATOM   2153 N N     . ARG C 1 16  ? -56.243 -12.871 80.281 1.00 43.49 ? 33  ARG B N     1 
ATOM   2154 C CA    . ARG C 1 16  ? -56.102 -14.293 80.679 1.00 46.89 ? 33  ARG B CA    1 
ATOM   2155 C C     . ARG C 1 16  ? -55.393 -15.068 79.560 1.00 45.61 ? 33  ARG B C     1 
ATOM   2156 O O     . ARG C 1 16  ? -54.505 -15.875 79.882 1.00 39.08 ? 33  ARG B O     1 
ATOM   2157 C CB    . ARG C 1 16  ? -57.474 -14.898 80.998 1.00 44.16 ? 33  ARG B CB    1 
ATOM   2158 N N     . GLU C 1 17  ? -55.742 -14.802 78.298 1.00 44.37 ? 34  GLU B N     1 
ATOM   2159 C CA    . GLU C 1 17  ? -55.125 -15.527 77.161 1.00 43.42 ? 34  GLU B CA    1 
ATOM   2160 C C     . GLU C 1 17  ? -53.613 -15.278 77.127 1.00 38.11 ? 34  GLU B C     1 
ATOM   2161 O O     . GLU C 1 17  ? -52.877 -16.241 76.914 1.00 35.32 ? 34  GLU B O     1 
ATOM   2162 C CB    . GLU C 1 17  ? -55.786 -15.102 75.851 1.00 48.22 ? 34  GLU B CB    1 
ATOM   2163 C CG    . GLU C 1 17  ? -54.930 -15.355 74.629 1.00 48.54 ? 34  GLU B CG    1 
ATOM   2164 C CD    . GLU C 1 17  ? -55.714 -15.353 73.330 1.00 55.45 ? 34  GLU B CD    1 
ATOM   2165 O OE1   . GLU C 1 17  ? -56.787 -15.977 73.293 1.00 58.09 ? 34  GLU B OE1   1 
ATOM   2166 O OE2   . GLU C 1 17  ? -55.255 -14.720 72.365 1.00 55.46 ? 34  GLU B OE2   1 
ATOM   2167 N N     . ASP C 1 18  ? -53.168 -14.040 77.343 1.00 41.16 ? 35  ASP B N     1 
ATOM   2168 C CA    . ASP C 1 18  ? -51.707 -13.766 77.309 1.00 39.11 ? 35  ASP B CA    1 
ATOM   2169 C C     . ASP C 1 18  ? -51.021 -14.550 78.433 1.00 33.67 ? 35  ASP B C     1 
ATOM   2170 O O     . ASP C 1 18  ? -49.938 -15.082 78.195 1.00 29.16 ? 35  ASP B O     1 
ATOM   2171 C CB    . ASP C 1 18  ? -51.391 -12.273 77.412 1.00 41.47 ? 35  ASP B CB    1 
ATOM   2172 C CG    . ASP C 1 18  ? -51.970 -11.437 76.284 1.00 47.13 ? 35  ASP B CG    1 
ATOM   2173 O OD1   . ASP C 1 18  ? -52.991 -10.789 76.519 1.00 54.17 ? 35  ASP B OD1   1 
ATOM   2174 O OD2   . ASP C 1 18  ? -51.387 -11.439 75.188 1.00 47.69 ? 35  ASP B OD2   1 
ATOM   2175 N N     . ARG C 1 19  ? -51.629 -14.580 79.620 1.00 31.36 ? 36  ARG B N     1 
ATOM   2176 C CA    . ARG C 1 19  ? -51.036 -15.307 80.773 1.00 33.77 ? 36  ARG B CA    1 
ATOM   2177 C C     . ARG C 1 19  ? -50.994 -16.806 80.478 1.00 31.10 ? 36  ARG B C     1 
ATOM   2178 O O     . ARG C 1 19  ? -49.980 -17.446 80.787 1.00 25.64 ? 36  ARG B O     1 
ATOM   2179 C CB    . ARG C 1 19  ? -51.871 -15.046 82.027 1.00 35.35 ? 36  ARG B CB    1 
ATOM   2180 C CG    . ARG C 1 19  ? -52.026 -13.569 82.343 1.00 38.11 ? 36  ARG B CG    1 
ATOM   2181 C CD    . ARG C 1 19  ? -52.921 -13.253 83.521 1.00 36.39 ? 36  ARG B CD    1 
ATOM   2182 N NE    . ARG C 1 19  ? -52.768 -11.827 83.734 1.00 42.96 ? 36  ARG B NE    1 
ATOM   2183 C CZ    . ARG C 1 19  ? -51.827 -11.275 84.481 1.00 40.72 ? 36  ARG B CZ    1 
ATOM   2184 N NH1   . ARG C 1 19  ? -50.979 -12.034 85.146 1.00 33.27 ? 36  ARG B NH1   1 
ATOM   2185 N NH2   . ARG C 1 19  ? -51.759 -9.961  84.583 1.00 38.85 ? 36  ARG B NH2   1 
ATOM   2186 N N     . THR C 1 20  ? -52.092 -17.329 79.936 1.00 27.96 ? 37  THR B N     1 
ATOM   2187 C CA    . THR C 1 20  ? -52.202 -18.766 79.574 1.00 25.59 ? 37  THR B CA    1 
ATOM   2188 C C     . THR C 1 20  ? -51.250 -19.086 78.417 1.00 27.47 ? 37  THR B C     1 
ATOM   2189 O O     . THR C 1 20  ? -50.723 -20.189 78.390 1.00 23.54 ? 37  THR B O     1 
ATOM   2190 C CB    . THR C 1 20  ? -53.664 -19.181 79.385 1.00 33.46 ? 37  THR B CB    1 
ATOM   2191 O OG1   . THR C 1 20  ? -54.215 -18.373 78.350 1.00 37.68 ? 37  THR B OG1   1 
ATOM   2192 C CG2   . THR C 1 20  ? -54.477 -18.999 80.646 1.00 33.32 ? 37  THR B CG2   1 
ATOM   2193 N N     . LEU C 1 21  ? -51.113 -18.180 77.451 1.00 21.86 ? 38  LEU B N     1 
ATOM   2194 C CA    . LEU C 1 21  ? -50.160 -18.440 76.345 1.00 24.95 ? 38  LEU B CA    1 
ATOM   2195 C C     . LEU C 1 21  ? -48.741 -18.488 76.919 1.00 25.75 ? 38  LEU B C     1 
ATOM   2196 O O     . LEU C 1 21  ? -47.977 -19.370 76.524 1.00 23.95 ? 38  LEU B O     1 
ATOM   2197 C CB    . LEU C 1 21  ? -50.309 -17.362 75.267 1.00 25.79 ? 38  LEU B CB    1 
ATOM   2198 C CG    . LEU C 1 21  ? -51.392 -17.653 74.234 1.00 33.29 ? 38  LEU B CG    1 
ATOM   2199 C CD1   . LEU C 1 21  ? -51.649 -16.445 73.353 1.00 36.50 ? 38  LEU B CD1   1 
ATOM   2200 C CD2   . LEU C 1 21  ? -51.020 -18.862 73.393 1.00 31.77 ? 38  LEU B CD2   1 
ATOM   2201 N N     . TYR C 1 22  ? -48.425 -17.580 77.842 1.00 25.24 ? 39  TYR B N     1 
ATOM   2202 C CA    . TYR C 1 22  ? -47.066 -17.559 78.440 1.00 22.13 ? 39  TYR B CA    1 
ATOM   2203 C C     . TYR C 1 22  ? -46.769 -18.917 79.081 1.00 23.63 ? 39  TYR B C     1 
ATOM   2204 O O     . TYR C 1 22  ? -45.748 -19.519 78.746 1.00 22.06 ? 39  TYR B O     1 
ATOM   2205 C CB    . TYR C 1 22  ? -46.911 -16.411 79.439 1.00 24.02 ? 39  TYR B CB    1 
ATOM   2206 C CG    . TYR C 1 22  ? -45.511 -16.252 79.970 1.00 23.12 ? 39  TYR B CG    1 
ATOM   2207 C CD1   . TYR C 1 22  ? -44.982 -17.165 80.861 1.00 25.97 ? 39  TYR B CD1   1 
ATOM   2208 C CD2   . TYR C 1 22  ? -44.704 -15.206 79.561 1.00 26.92 ? 39  TYR B CD2   1 
ATOM   2209 C CE1   . TYR C 1 22  ? -43.694 -17.037 81.348 1.00 22.52 ? 39  TYR B CE1   1 
ATOM   2210 C CE2   . TYR C 1 22  ? -43.412 -15.065 80.034 1.00 27.79 ? 39  TYR B CE2   1 
ATOM   2211 C CZ    . TYR C 1 22  ? -42.905 -15.984 80.932 1.00 26.89 ? 39  TYR B CZ    1 
ATOM   2212 O OH    . TYR C 1 22  ? -41.634 -15.855 81.402 1.00 29.20 ? 39  TYR B OH    1 
ATOM   2213 N N     . GLU C 1 23  ? -47.645 -19.386 79.971 1.00 21.71 ? 40  GLU B N     1 
ATOM   2214 C CA    . GLU C 1 23  ? -47.389 -20.672 80.607 1.00 23.46 ? 40  GLU B CA    1 
ATOM   2215 C C     . GLU C 1 23  ? -47.352 -21.807 79.583 1.00 21.86 ? 40  GLU B C     1 
ATOM   2216 O O     . GLU C 1 23  ? -46.541 -22.730 79.711 1.00 23.05 ? 40  GLU B O     1 
ATOM   2217 C CB    . GLU C 1 23  ? -48.420 -20.936 81.714 1.00 27.77 ? 40  GLU B CB    1 
ATOM   2218 C CG    . GLU C 1 23  ? -49.792 -21.351 81.215 1.00 31.98 ? 40  GLU B CG    1 
ATOM   2219 C CD    . GLU C 1 23  ? -50.033 -22.857 81.223 1.00 33.30 ? 40  GLU B CD    1 
ATOM   2220 O OE1   . GLU C 1 23  ? -51.205 -23.250 81.072 1.00 35.62 ? 40  GLU B OE1   1 
ATOM   2221 O OE2   . GLU C 1 23  ? -49.064 -23.648 81.352 1.00 35.81 ? 40  GLU B OE2   1 
ATOM   2222 N N     . ARG C 1 24  ? -48.210 -21.757 78.553 1.00 21.34 ? 41  ARG B N     1 
ATOM   2223 C CA    . ARG C 1 24  ? -48.186 -22.814 77.543 1.00 22.99 ? 41  ARG B CA    1 
ATOM   2224 C C     . ARG C 1 24  ? -46.854 -22.835 76.813 1.00 21.54 ? 41  ARG B C     1 
ATOM   2225 O O     . ARG C 1 24  ? -46.284 -23.904 76.574 1.00 21.76 ? 41  ARG B O     1 
ATOM   2226 C CB    . ARG C 1 24  ? -49.331 -22.645 76.538 1.00 23.36 ? 41  ARG B CB    1 
ATOM   2227 C CG    . ARG C 1 24  ? -50.661 -23.168 77.039 1.00 24.93 ? 41  ARG B CG    1 
ATOM   2228 C CD    . ARG C 1 24  ? -51.830 -22.719 76.181 1.00 27.95 ? 41  ARG B CD    1 
ATOM   2229 N NE    . ARG C 1 24  ? -51.757 -23.212 74.805 1.00 25.75 ? 41  ARG B NE    1 
ATOM   2230 C CZ    . ARG C 1 24  ? -52.423 -22.673 73.795 1.00 27.79 ? 41  ARG B CZ    1 
ATOM   2231 N NH1   . ARG C 1 24  ? -53.255 -21.657 73.981 1.00 27.82 ? 41  ARG B NH1   1 
ATOM   2232 N NH2   . ARG C 1 24  ? -52.253 -23.164 72.568 1.00 26.52 ? 41  ARG B NH2   1 
ATOM   2233 N N     . ILE C 1 25  ? -46.340 -21.662 76.459 1.00 19.55 ? 42  ILE B N     1 
ATOM   2234 C CA    . ILE C 1 25  ? -45.058 -21.598 75.755 1.00 20.77 ? 42  ILE B CA    1 
ATOM   2235 C C     . ILE C 1 25  ? -43.934 -22.138 76.633 1.00 20.54 ? 42  ILE B C     1 
ATOM   2236 O O     . ILE C 1 25  ? -43.132 -22.972 76.195 1.00 17.92 ? 42  ILE B O     1 
ATOM   2237 C CB    . ILE C 1 25  ? -44.792 -20.165 75.267 1.00 20.12 ? 42  ILE B CB    1 
ATOM   2238 C CG1   . ILE C 1 25  ? -45.839 -19.814 74.205 1.00 18.28 ? 42  ILE B CG1   1 
ATOM   2239 C CG2   . ILE C 1 25  ? -43.368 -20.010 74.697 1.00 20.17 ? 42  ILE B CG2   1 
ATOM   2240 C CD1   . ILE C 1 25  ? -46.025 -18.320 73.977 1.00 19.61 ? 42  ILE B CD1   1 
ATOM   2241 N N     . VAL C 1 26  ? -43.862 -21.690 77.891 1.00 19.53 ? 43  VAL B N     1 
ATOM   2242 C CA    . VAL C 1 26  ? -42.851 -22.238 78.799 1.00 19.69 ? 43  VAL B CA    1 
ATOM   2243 C C     . VAL C 1 26  ? -42.962 -23.759 78.871 1.00 21.21 ? 43  VAL B C     1 
ATOM   2244 O O     . VAL C 1 26  ? -41.952 -24.477 78.809 1.00 22.44 ? 43  VAL B O     1 
ATOM   2245 C CB    . VAL C 1 26  ? -42.979 -21.611 80.203 1.00 26.03 ? 43  VAL B CB    1 
ATOM   2246 C CG1   . VAL C 1 26  ? -42.027 -22.309 81.154 1.00 27.35 ? 43  VAL B CG1   1 
ATOM   2247 C CG2   . VAL C 1 26  ? -42.642 -20.140 80.154 1.00 23.17 ? 43  VAL B CG2   1 
ATOM   2248 N N     . SER C 1 27  ? -44.187 -24.271 79.002 1.00 21.20 ? 44  SER B N     1 
ATOM   2249 C CA    . SER C 1 27  ? -44.365 -25.710 79.185 1.00 25.54 ? 44  SER B CA    1 
ATOM   2250 C C     . SER C 1 27  ? -43.847 -26.479 77.982 1.00 22.21 ? 44  SER B C     1 
ATOM   2251 O O     . SER C 1 27  ? -43.158 -27.497 78.133 1.00 22.93 ? 44  SER B O     1 
ATOM   2252 C CB    . SER C 1 27  ? -45.840 -26.039 79.435 1.00 25.12 ? 44  SER B CB    1 
ATOM   2253 O OG    . SER C 1 27  ? -46.324 -25.322 80.561 1.00 29.67 ? 44  SER B OG    1 
ATOM   2254 N N     . ARG C 1 28  ? -44.149 -25.996 76.774 1.00 19.85 ? 45  ARG B N     1 
ATOM   2255 C CA    . ARG C 1 28  ? -43.705 -26.709 75.584 1.00 23.61 ? 45  ARG B CA    1 
ATOM   2256 C C     . ARG C 1 28  ? -42.214 -26.513 75.329 1.00 20.33 ? 45  ARG B C     1 
ATOM   2257 O O     . ARG C 1 28  ? -41.529 -27.459 74.932 1.00 20.35 ? 45  ARG B O     1 
ATOM   2258 C CB    . ARG C 1 28  ? -44.531 -26.295 74.369 1.00 22.51 ? 45  ARG B CB    1 
ATOM   2259 C CG    . ARG C 1 28  ? -44.308 -27.250 73.215 1.00 23.04 ? 45  ARG B CG    1 
ATOM   2260 C CD    . ARG C 1 28  ? -44.695 -28.715 73.606 1.00 31.36 ? 45  ARG B CD    1 
ATOM   2261 N NE    . ARG C 1 28  ? -45.348 -29.413 72.501 1.00 34.68 ? 45  ARG B NE    1 
ATOM   2262 C CZ    . ARG C 1 28  ? -46.448 -30.147 72.587 1.00 30.50 ? 45  ARG B CZ    1 
ATOM   2263 N NH1   . ARG C 1 28  ? -47.113 -30.279 73.726 1.00 31.20 ? 45  ARG B NH1   1 
ATOM   2264 N NH2   . ARG C 1 28  ? -46.886 -30.777 71.503 1.00 32.65 ? 45  ARG B NH2   1 
ATOM   2265 N N     . LEU C 1 29  ? -41.680 -25.308 75.578 1.00 20.98 ? 46  LEU B N     1 
ATOM   2266 C CA    . LEU C 1 29  ? -40.234 -25.104 75.453 1.00 19.80 ? 46  LEU B CA    1 
ATOM   2267 C C     . LEU C 1 29  ? -39.448 -26.059 76.348 1.00 22.39 ? 46  LEU B C     1 
ATOM   2268 O O     . LEU C 1 29  ? -38.339 -26.488 75.993 1.00 21.31 ? 46  LEU B O     1 
ATOM   2269 C CB    . LEU C 1 29  ? -39.860 -23.663 75.807 1.00 19.34 ? 46  LEU B CB    1 
ATOM   2270 C CG    . LEU C 1 29  ? -40.292 -22.571 74.833 1.00 19.69 ? 46  LEU B CG    1 
ATOM   2271 C CD1   . LEU C 1 29  ? -39.831 -21.194 75.368 1.00 20.37 ? 46  LEU B CD1   1 
ATOM   2272 C CD2   . LEU C 1 29  ? -39.687 -22.856 73.456 1.00 19.21 ? 46  LEU B CD2   1 
ATOM   2273 N N     . ARG C 1 30  ? -40.006 -26.408 77.505 1.00 19.47 ? 47  ARG B N     1 
ATOM   2274 C CA    . ARG C 1 30  ? -39.303 -27.297 78.422 1.00 23.48 ? 47  ARG B CA    1 
ATOM   2275 C C     . ARG C 1 30  ? -39.092 -28.675 77.813 1.00 20.93 ? 47  ARG B C     1 
ATOM   2276 O O     . ARG C 1 30  ? -38.160 -29.378 78.207 1.00 22.21 ? 47  ARG B O     1 
ATOM   2277 C CB    . ARG C 1 30  ? -40.076 -27.407 79.736 1.00 23.05 ? 47  ARG B CB    1 
ATOM   2278 C CG    . ARG C 1 30  ? -39.831 -26.235 80.657 1.00 27.37 ? 47  ARG B CG    1 
ATOM   2279 C CD    . ARG C 1 30  ? -40.528 -26.439 81.970 1.00 30.11 ? 47  ARG B CD    1 
ATOM   2280 N NE    . ARG C 1 30  ? -40.229 -27.746 82.551 1.00 37.06 ? 47  ARG B NE    1 
ATOM   2281 C CZ    . ARG C 1 30  ? -39.425 -27.934 83.590 1.00 38.07 ? 47  ARG B CZ    1 
ATOM   2282 N NH1   . ARG C 1 30  ? -38.925 -26.916 84.269 1.00 39.35 ? 47  ARG B NH1   1 
ATOM   2283 N NH2   . ARG C 1 30  ? -39.123 -29.175 83.966 1.00 41.86 ? 47  ARG B NH2   1 
ATOM   2284 N N     . ARG C 1 31  ? -39.931 -29.074 76.856 1.00 18.70 ? 48  ARG B N     1 
ATOM   2285 C CA    . ARG C 1 31  ? -39.691 -30.325 76.162 1.00 23.07 ? 48  ARG B CA    1 
ATOM   2286 C C     . ARG C 1 31  ? -38.370 -30.290 75.414 1.00 20.86 ? 48  ARG B C     1 
ATOM   2287 O O     . ARG C 1 31  ? -37.672 -31.314 75.331 1.00 22.61 ? 48  ARG B O     1 
ATOM   2288 C CB    . ARG C 1 31  ? -40.843 -30.605 75.203 1.00 20.04 ? 48  ARG B CB    1 
ATOM   2289 C CG    . ARG C 1 31  ? -40.682 -31.833 74.335 1.00 27.26 ? 48  ARG B CG    1 
ATOM   2290 C CD    . ARG C 1 31  ? -41.996 -32.111 73.614 1.00 28.84 ? 48  ARG B CD    1 
ATOM   2291 N NE    . ARG C 1 31  ? -43.087 -32.376 74.544 1.00 33.96 ? 48  ARG B NE    1 
ATOM   2292 C CZ    . ARG C 1 31  ? -44.294 -32.788 74.179 1.00 34.73 ? 48  ARG B CZ    1 
ATOM   2293 N NH1   . ARG C 1 31  ? -44.609 -32.956 72.903 1.00 29.84 ? 48  ARG B NH1   1 
ATOM   2294 N NH2   . ARG C 1 31  ? -45.209 -33.027 75.115 1.00 36.93 ? 48  ARG B NH2   1 
ATOM   2295 N N     . PHE C 1 32  ? -37.992 -29.124 74.895 1.00 17.22 ? 49  PHE B N     1 
ATOM   2296 C CA    . PHE C 1 32  ? -36.883 -29.019 73.961 1.00 21.22 ? 49  PHE B CA    1 
ATOM   2297 C C     . PHE C 1 32  ? -35.620 -28.427 74.545 1.00 22.39 ? 49  PHE B C     1 
ATOM   2298 O O     . PHE C 1 32  ? -34.606 -28.386 73.846 1.00 23.13 ? 49  PHE B O     1 
ATOM   2299 C CB    . PHE C 1 32  ? -37.321 -28.207 72.738 1.00 21.69 ? 49  PHE B CB    1 
ATOM   2300 C CG    . PHE C 1 32  ? -38.450 -28.845 72.002 1.00 21.78 ? 49  PHE B CG    1 
ATOM   2301 C CD1   . PHE C 1 32  ? -38.258 -30.040 71.350 1.00 21.44 ? 49  PHE B CD1   1 
ATOM   2302 C CD2   . PHE C 1 32  ? -39.723 -28.291 72.028 1.00 23.77 ? 49  PHE B CD2   1 
ATOM   2303 C CE1   . PHE C 1 32  ? -39.302 -30.656 70.677 1.00 26.87 ? 49  PHE B CE1   1 
ATOM   2304 C CE2   . PHE C 1 32  ? -40.769 -28.905 71.371 1.00 21.84 ? 49  PHE B CE2   1 
ATOM   2305 C CZ    . PHE C 1 32  ? -40.558 -30.084 70.692 1.00 25.08 ? 49  PHE B CZ    1 
ATOM   2306 N N     . GLY C 1 33  ? -35.635 -27.978 75.794 1.00 20.95 ? 50  GLY B N     1 
ATOM   2307 C CA    . GLY C 1 33  ? -34.394 -27.485 76.353 1.00 22.70 ? 50  GLY B CA    1 
ATOM   2308 C C     . GLY C 1 33  ? -34.608 -26.946 77.745 1.00 22.47 ? 50  GLY B C     1 
ATOM   2309 O O     . GLY C 1 33  ? -35.715 -26.971 78.287 1.00 23.50 ? 50  GLY B O     1 
ATOM   2310 N N     . THR C 1 34  ? -33.510 -26.459 78.319 1.00 24.10 ? 51  THR B N     1 
ATOM   2311 C CA    . THR C 1 34  ? -33.564 -25.748 79.586 1.00 27.77 ? 51  THR B CA    1 
ATOM   2312 C C     . THR C 1 34  ? -34.112 -24.355 79.341 1.00 24.89 ? 51  THR B C     1 
ATOM   2313 O O     . THR C 1 34  ? -33.558 -23.603 78.534 1.00 27.20 ? 51  THR B O     1 
ATOM   2314 C CB    . THR C 1 34  ? -32.181 -25.657 80.218 1.00 26.75 ? 51  THR B CB    1 
ATOM   2315 O OG1   . THR C 1 34  ? -31.679 -26.982 80.434 1.00 33.68 ? 51  THR B OG1   1 
ATOM   2316 C CG2   . THR C 1 34  ? -32.290 -24.932 81.546 1.00 26.00 ? 51  THR B CG2   1 
ATOM   2317 N N     . VAL C 1 35  ? -35.180 -24.002 80.045 1.00 24.18 ? 52  VAL B N     1 
ATOM   2318 C CA    . VAL C 1 35  ? -35.910 -22.775 79.765 1.00 23.27 ? 52  VAL B CA    1 
ATOM   2319 C C     . VAL C 1 35  ? -35.478 -21.716 80.763 1.00 27.25 ? 52  VAL B C     1 
ATOM   2320 O O     . VAL C 1 35  ? -35.657 -21.881 81.974 1.00 26.86 ? 52  VAL B O     1 
ATOM   2321 C CB    . VAL C 1 35  ? -37.427 -22.995 79.808 1.00 26.13 ? 52  VAL B CB    1 
ATOM   2322 C CG1   . VAL C 1 35  ? -38.150 -21.654 79.703 1.00 27.91 ? 52  VAL B CG1   1 
ATOM   2323 C CG2   . VAL C 1 35  ? -37.847 -23.904 78.662 1.00 26.67 ? 52  VAL B CG2   1 
ATOM   2324 N N     . LEU C 1 36  ? -34.901 -20.646 80.249 1.00 24.84 ? 53  LEU B N     1 
ATOM   2325 C CA    . LEU C 1 36  ? -34.567 -19.458 81.018 1.00 26.12 ? 53  LEU B CA    1 
ATOM   2326 C C     . LEU C 1 36  ? -35.634 -18.408 80.735 1.00 28.76 ? 53  LEU B C     1 
ATOM   2327 O O     . LEU C 1 36  ? -35.994 -18.190 79.575 1.00 24.33 ? 53  LEU B O     1 
ATOM   2328 C CB    . LEU C 1 36  ? -33.188 -18.949 80.605 1.00 27.35 ? 53  LEU B CB    1 
ATOM   2329 C CG    . LEU C 1 36  ? -32.146 -20.070 80.564 1.00 33.02 ? 53  LEU B CG    1 
ATOM   2330 C CD1   . LEU C 1 36  ? -30.825 -19.595 79.985 1.00 35.04 ? 53  LEU B CD1   1 
ATOM   2331 C CD2   . LEU C 1 36  ? -31.965 -20.616 81.981 1.00 35.30 ? 53  LEU B CD2   1 
ATOM   2332 N N     . THR C 1 37  ? -36.156 -17.772 81.780 1.00 25.20 ? 54  THR B N     1 
ATOM   2333 C CA    . THR C 1 37  ? -37.182 -16.756 81.591 1.00 25.80 ? 54  THR B CA    1 
ATOM   2334 C C     . THR C 1 37  ? -36.680 -15.396 82.053 1.00 32.40 ? 54  THR B C     1 
ATOM   2335 O O     . THR C 1 37  ? -35.834 -15.293 82.945 1.00 31.97 ? 54  THR B O     1 
ATOM   2336 C CB    . THR C 1 37  ? -38.469 -17.103 82.353 1.00 30.19 ? 54  THR B CB    1 
ATOM   2337 O OG1   . THR C 1 37  ? -38.135 -17.482 83.689 1.00 36.10 ? 54  THR B OG1   1 
ATOM   2338 C CG2   . THR C 1 37  ? -39.197 -18.258 81.691 1.00 26.67 ? 54  THR B CG2   1 
ATOM   2339 N N     . GLU C 1 38  ? -37.208 -14.346 81.432 1.00 33.89 ? 55  GLU B N     1 
ATOM   2340 C CA    . GLU C 1 38  ? -36.955 -13.008 81.939 1.00 39.91 ? 55  GLU B CA    1 
ATOM   2341 C C     . GLU C 1 38  ? -37.634 -12.855 83.288 1.00 46.39 ? 55  GLU B C     1 
ATOM   2342 O O     . GLU C 1 38  ? -38.765 -13.304 83.487 1.00 46.85 ? 55  GLU B O     1 
ATOM   2343 C CB    . GLU C 1 38  ? -37.474 -11.941 80.976 1.00 40.66 ? 55  GLU B CB    1 
ATOM   2344 C CG    . GLU C 1 38  ? -37.269 -10.515 81.481 1.00 42.55 ? 55  GLU B CG    1 
ATOM   2345 C CD    . GLU C 1 38  ? -37.627 -9.469  80.446 1.00 44.29 ? 55  GLU B CD    1 
ATOM   2346 O OE1   . GLU C 1 38  ? -38.065 -9.861  79.349 1.00 40.63 ? 55  GLU B OE1   1 
ATOM   2347 O OE2   . GLU C 1 38  ? -37.483 -8.259  80.727 1.00 48.53 ? 55  GLU B OE2   1 
ATOM   2348 N N     . HIS C 1 39  ? -36.939 -12.235 84.226 1.00 48.96 ? 56  HIS B N     1 
ATOM   2349 C CA    . HIS C 1 39  ? -37.515 -11.920 85.521 1.00 54.03 ? 56  HIS B CA    1 
ATOM   2350 C C     . HIS C 1 39  ? -37.817 -10.428 85.554 1.00 56.94 ? 56  HIS B C     1 
ATOM   2351 O O     . HIS C 1 39  ? -36.909 -9.606  85.393 1.00 57.18 ? 56  HIS B O     1 
ATOM   2352 C CB    . HIS C 1 39  ? -36.574 -12.346 86.646 1.00 57.61 ? 56  HIS B CB    1 
ATOM   2353 C CG    . HIS C 1 39  ? -36.663 -13.807 86.971 1.00 62.09 ? 56  HIS B CG    1 
ATOM   2354 N ND1   . HIS C 1 39  ? -37.816 -14.540 86.779 1.00 60.71 ? 56  HIS B ND1   1 
ATOM   2355 C CD2   . HIS C 1 39  ? -35.741 -14.678 87.444 1.00 64.86 ? 56  HIS B CD2   1 
ATOM   2356 C CE1   . HIS C 1 39  ? -37.604 -15.794 87.138 1.00 57.23 ? 56  HIS B CE1   1 
ATOM   2357 N NE2   . HIS C 1 39  ? -36.352 -15.905 87.542 1.00 60.50 ? 56  HIS B NE2   1 
ATOM   2358 N N     . VAL C 1 40  ? -39.093 -10.084 85.716 1.00 58.31 ? 57  VAL B N     1 
ATOM   2359 C CA    . VAL C 1 40  ? -39.505 -8.684  85.790 1.00 59.89 ? 57  VAL B CA    1 
ATOM   2360 C C     . VAL C 1 40  ? -40.227 -8.425  87.108 1.00 63.60 ? 57  VAL B C     1 
ATOM   2361 O O     . VAL C 1 40  ? -39.715 -7.716  87.976 1.00 63.50 ? 57  VAL B O     1 
ATOM   2362 C CB    . VAL C 1 40  ? -40.394 -8.292  84.596 1.00 59.77 ? 57  VAL B CB    1 
ATOM   2363 N N     . GLY C 1 55  ? -31.503 -3.754  91.871 1.00 59.73 ? 72  GLY B N     1 
ATOM   2364 C CA    . GLY C 1 55  ? -32.770 -3.584  91.183 1.00 61.55 ? 72  GLY B CA    1 
ATOM   2365 C C     . GLY C 1 55  ? -32.682 -3.683  89.670 1.00 57.94 ? 72  GLY B C     1 
ATOM   2366 O O     . GLY C 1 55  ? -32.432 -4.758  89.125 1.00 58.00 ? 72  GLY B O     1 
ATOM   2367 N N     . ASP C 1 56  ? -32.877 -2.550  88.987 1.00 57.23 ? 73  ASP B N     1 
ATOM   2368 C CA    . ASP C 1 56  ? -32.964 -2.576  87.527 1.00 53.61 ? 73  ASP B CA    1 
ATOM   2369 C C     . ASP C 1 56  ? -31.615 -2.827  86.860 1.00 50.89 ? 73  ASP B C     1 
ATOM   2370 O O     . ASP C 1 56  ? -31.576 -3.468  85.805 1.00 48.13 ? 73  ASP B O     1 
ATOM   2371 C CB    . ASP C 1 56  ? -33.606 -1.284  87.014 1.00 49.82 ? 73  ASP B CB    1 
ATOM   2372 C CG    . ASP C 1 56  ? -35.059 -1.145  87.463 1.00 52.78 ? 73  ASP B CG    1 
ATOM   2373 O OD1   . ASP C 1 56  ? -35.473 -1.901  88.370 1.00 60.18 ? 73  ASP B OD1   1 
ATOM   2374 O OD2   . ASP C 1 56  ? -35.788 -0.291  86.910 1.00 48.66 ? 73  ASP B OD2   1 
ATOM   2375 N N     . ARG C 1 57  ? -30.501 -2.360  87.439 1.00 46.03 ? 74  ARG B N     1 
ATOM   2376 C CA    . ARG C 1 57  ? -29.211 -2.738  86.863 1.00 51.62 ? 74  ARG B CA    1 
ATOM   2377 C C     . ARG C 1 57  ? -28.980 -4.241  87.011 1.00 52.44 ? 74  ARG B C     1 
ATOM   2378 O O     . ARG C 1 57  ? -28.470 -4.891  86.089 1.00 52.73 ? 74  ARG B O     1 
ATOM   2379 C CB    . ARG C 1 57  ? -28.057 -1.954  87.502 1.00 51.39 ? 74  ARG B CB    1 
ATOM   2380 C CG    . ARG C 1 57  ? -26.711 -2.267  86.838 1.00 57.45 ? 74  ARG B CG    1 
ATOM   2381 C CD    . ARG C 1 57  ? -25.495 -1.534  87.422 1.00 59.59 ? 74  ARG B CD    1 
ATOM   2382 N NE    . ARG C 1 57  ? -25.145 -1.905  88.790 1.00 63.32 ? 74  ARG B NE    1 
ATOM   2383 C CZ    . ARG C 1 57  ? -25.382 -1.170  89.869 1.00 64.97 ? 74  ARG B CZ    1 
ATOM   2384 N NH1   . ARG C 1 57  ? -26.080 -0.046  89.805 1.00 67.55 ? 74  ARG B NH1   1 
ATOM   2385 N NH2   . ARG C 1 57  ? -24.898 -1.568  91.044 1.00 63.74 ? 74  ARG B NH2   1 
ATOM   2386 N N     . LEU C 1 58  ? -29.376 -4.807  88.159 1.00 49.92 ? 75  LEU B N     1 
ATOM   2387 C CA    . LEU C 1 58  ? -29.276 -6.251  88.381 1.00 53.06 ? 75  LEU B CA    1 
ATOM   2388 C C     . LEU C 1 58  ? -30.129 -7.024  87.381 1.00 54.25 ? 75  LEU B C     1 
ATOM   2389 O O     . LEU C 1 58  ? -29.659 -7.977  86.747 1.00 50.84 ? 75  LEU B O     1 
ATOM   2390 C CB    . LEU C 1 58  ? -29.710 -6.581  89.815 1.00 52.28 ? 75  LEU B CB    1 
ATOM   2391 C CG    . LEU C 1 58  ? -29.538 -8.017  90.342 1.00 59.15 ? 75  LEU B CG    1 
ATOM   2392 C CD1   . LEU C 1 58  ? -30.742 -8.923  90.029 1.00 54.64 ? 75  LEU B CD1   1 
ATOM   2393 C CD2   . LEU C 1 58  ? -28.246 -8.633  89.819 1.00 61.69 ? 75  LEU B CD2   1 
ATOM   2394 N N     . ILE C 1 59  ? -31.403 -6.643  87.261 1.00 52.34 ? 76  ILE B N     1 
ATOM   2395 C CA    . ILE C 1 59  ? -32.316 -7.265  86.304 1.00 47.62 ? 76  ILE B CA    1 
ATOM   2396 C C     . ILE C 1 59  ? -31.703 -7.261  84.911 1.00 48.97 ? 76  ILE B C     1 
ATOM   2397 O O     . ILE C 1 59  ? -31.538 -8.313  84.282 1.00 47.11 ? 76  ILE B O     1 
ATOM   2398 C CB    . ILE C 1 59  ? -33.683 -6.552  86.317 1.00 48.10 ? 76  ILE B CB    1 
ATOM   2399 C CG1   . ILE C 1 59  ? -34.393 -6.765  87.655 1.00 53.66 ? 76  ILE B CG1   1 
ATOM   2400 C CG2   . ILE C 1 59  ? -34.556 -6.992  85.154 1.00 42.14 ? 76  ILE B CG2   1 
ATOM   2401 C CD1   . ILE C 1 59  ? -35.548 -5.830  87.874 1.00 53.19 ? 76  ILE B CD1   1 
ATOM   2402 N N     . HIS C 1 60  ? -31.366 -6.067  84.404 1.00 42.86 ? 77  HIS B N     1 
ATOM   2403 C CA    . HIS C 1 60  ? -30.746 -5.963  83.084 1.00 45.81 ? 77  HIS B CA    1 
ATOM   2404 C C     . HIS C 1 60  ? -29.555 -6.907  82.964 1.00 47.86 ? 77  HIS B C     1 
ATOM   2405 O O     . HIS C 1 60  ? -29.463 -7.697  82.018 1.00 44.31 ? 77  HIS B O     1 
ATOM   2406 C CB    . HIS C 1 60  ? -30.309 -4.523  82.819 1.00 40.37 ? 77  HIS B CB    1 
ATOM   2407 C CG    . HIS C 1 60  ? -29.646 -4.331  81.491 1.00 38.39 ? 77  HIS B CG    1 
ATOM   2408 N ND1   . HIS C 1 60  ? -28.276 -4.282  81.343 1.00 43.16 ? 77  HIS B ND1   1 
ATOM   2409 C CD2   . HIS C 1 60  ? -30.162 -4.147  80.254 1.00 37.14 ? 77  HIS B CD2   1 
ATOM   2410 C CE1   . HIS C 1 60  ? -27.977 -4.100  80.069 1.00 41.40 ? 77  HIS B CE1   1 
ATOM   2411 N NE2   . HIS C 1 60  ? -29.104 -4.018  79.386 1.00 37.73 ? 77  HIS B NE2   1 
ATOM   2412 N N     . GLU C 1 61  ? -28.641 -6.843  83.937 1.00 51.31 ? 78  GLU B N     1 
ATOM   2413 C CA    . GLU C 1 61  ? -27.481 -7.730  83.990 1.00 51.58 ? 78  GLU B CA    1 
ATOM   2414 C C     . GLU C 1 61  ? -27.878 -9.203  83.915 1.00 49.31 ? 78  GLU B C     1 
ATOM   2415 O O     . GLU C 1 61  ? -27.501 -9.920  82.981 1.00 48.00 ? 78  GLU B O     1 
ATOM   2416 C CB    . GLU C 1 61  ? -26.708 -7.460  85.283 1.00 51.55 ? 78  GLU B CB    1 
ATOM   2417 N N     . GLN C 1 62  ? -28.633 -9.671  84.912 1.00 48.06 ? 79  GLN B N     1 
ATOM   2418 C CA    . GLN C 1 62  ? -28.925 -11.098 85.032 1.00 47.00 ? 79  GLN B CA    1 
ATOM   2419 C C     . GLN C 1 62  ? -29.698 -11.621 83.824 1.00 50.68 ? 79  GLN B C     1 
ATOM   2420 O O     . GLN C 1 62  ? -29.434 -12.729 83.336 1.00 45.28 ? 79  GLN B O     1 
ATOM   2421 C CB    . GLN C 1 62  ? -29.716 -11.346 86.314 1.00 50.84 ? 79  GLN B CB    1 
ATOM   2422 C CG    . GLN C 1 62  ? -30.446 -12.671 86.364 1.00 55.04 ? 79  GLN B CG    1 
ATOM   2423 C CD    . GLN C 1 62  ? -30.388 -13.302 87.745 1.00 64.94 ? 79  GLN B CD    1 
ATOM   2424 O OE1   . GLN C 1 62  ? -29.452 -13.066 88.511 1.00 66.34 ? 79  GLN B OE1   1 
ATOM   2425 N NE2   . GLN C 1 62  ? -31.400 -14.095 88.076 1.00 65.15 ? 79  GLN B NE2   1 
ATOM   2426 N N     . ASN C 1 63  ? -30.667 -10.844 83.333 1.00 47.56 ? 80  ASN B N     1 
ATOM   2427 C CA    . ASN C 1 63  ? -31.421 -11.292 82.168 1.00 45.78 ? 80  ASN B CA    1 
ATOM   2428 C C     . ASN C 1 63  ? -30.558 -11.264 80.921 1.00 41.96 ? 80  ASN B C     1 
ATOM   2429 O O     . ASN C 1 63  ? -30.671 -12.146 80.062 1.00 40.11 ? 80  ASN B O     1 
ATOM   2430 C CB    . ASN C 1 63  ? -32.675 -10.440 81.981 1.00 45.06 ? 80  ASN B CB    1 
ATOM   2431 C CG    . ASN C 1 63  ? -33.743 -10.754 83.007 1.00 46.19 ? 80  ASN B CG    1 
ATOM   2432 O OD1   . ASN C 1 63  ? -33.941 -11.913 83.380 1.00 49.07 ? 80  ASN B OD1   1 
ATOM   2433 N ND2   . ASN C 1 63  ? -34.453 -9.729  83.457 1.00 48.33 ? 80  ASN B ND2   1 
ATOM   2434 N N     . LEU C 1 64  ? -29.686 -10.265 80.802 1.00 40.53 ? 81  LEU B N     1 
ATOM   2435 C CA    . LEU C 1 64  ? -28.783 -10.255 79.664 1.00 39.79 ? 81  LEU B CA    1 
ATOM   2436 C C     . LEU C 1 64  ? -27.801 -11.418 79.748 1.00 42.19 ? 81  LEU B C     1 
ATOM   2437 O O     . LEU C 1 64  ? -27.419 -11.969 78.718 1.00 37.58 ? 81  LEU B O     1 
ATOM   2438 C CB    . LEU C 1 64  ? -28.056 -8.914  79.574 1.00 44.02 ? 81  LEU B CB    1 
ATOM   2439 C CG    . LEU C 1 64  ? -27.653 -8.470  78.166 1.00 47.56 ? 81  LEU B CG    1 
ATOM   2440 C CD1   . LEU C 1 64  ? -28.813 -7.735  77.513 1.00 45.08 ? 81  LEU B CD1   1 
ATOM   2441 C CD2   . LEU C 1 64  ? -26.428 -7.582  78.196 1.00 43.16 ? 81  LEU B CD2   1 
ATOM   2442 N N     . GLU C 1 65  ? -27.435 -11.844 80.959 1.00 43.06 ? 82  GLU B N     1 
ATOM   2443 C CA    . GLU C 1 65  ? -26.515 -12.971 81.096 1.00 47.04 ? 82  GLU B CA    1 
ATOM   2444 C C     . GLU C 1 65  ? -27.187 -14.269 80.654 1.00 43.68 ? 82  GLU B C     1 
ATOM   2445 O O     . GLU C 1 65  ? -26.593 -15.069 79.921 1.00 42.36 ? 82  GLU B O     1 
ATOM   2446 C CB    . GLU C 1 65  ? -26.024 -13.080 82.545 1.00 49.59 ? 82  GLU B CB    1 
ATOM   2447 C CG    . GLU C 1 65  ? -24.545 -13.491 82.704 1.00 62.41 ? 82  GLU B CG    1 
ATOM   2448 C CD    . GLU C 1 65  ? -24.303 -14.991 82.682 1.00 70.96 ? 82  GLU B CD    1 
ATOM   2449 O OE1   . GLU C 1 65  ? -23.672 -15.477 81.718 1.00 78.22 ? 82  GLU B OE1   1 
ATOM   2450 O OE2   . GLU C 1 65  ? -24.747 -15.689 83.612 1.00 73.53 ? 82  GLU B OE2   1 
ATOM   2451 N N     . TRP C 1 66  ? -28.429 -14.499 81.094 1.00 43.18 ? 83  TRP B N     1 
ATOM   2452 C CA    . TRP C 1 66  ? -29.195 -15.626 80.575 1.00 40.12 ? 83  TRP B CA    1 
ATOM   2453 C C     . TRP C 1 66  ? -29.328 -15.544 79.062 1.00 37.25 ? 83  TRP B C     1 
ATOM   2454 O O     . TRP C 1 66  ? -29.241 -16.554 78.356 1.00 34.85 ? 83  TRP B O     1 
ATOM   2455 C CB    . TRP C 1 66  ? -30.583 -15.671 81.209 1.00 37.30 ? 83  TRP B CB    1 
ATOM   2456 C CG    . TRP C 1 66  ? -30.625 -16.244 82.576 1.00 42.67 ? 83  TRP B CG    1 
ATOM   2457 C CD1   . TRP C 1 66  ? -29.825 -17.224 83.082 1.00 44.09 ? 83  TRP B CD1   1 
ATOM   2458 C CD2   . TRP C 1 66  ? -31.551 -15.904 83.608 1.00 47.21 ? 83  TRP B CD2   1 
ATOM   2459 N NE1   . TRP C 1 66  ? -30.186 -17.503 84.379 1.00 53.10 ? 83  TRP B NE1   1 
ATOM   2460 C CE2   . TRP C 1 66  ? -31.244 -16.705 84.725 1.00 53.70 ? 83  TRP B CE2   1 
ATOM   2461 C CE3   . TRP C 1 66  ? -32.604 -14.985 83.701 1.00 52.51 ? 83  TRP B CE3   1 
ATOM   2462 C CZ2   . TRP C 1 66  ? -31.953 -16.618 85.923 1.00 59.34 ? 83  TRP B CZ2   1 
ATOM   2463 C CZ3   . TRP C 1 66  ? -33.310 -14.900 84.895 1.00 54.41 ? 83  TRP B CZ3   1 
ATOM   2464 C CH2   . TRP C 1 66  ? -32.980 -15.712 85.987 1.00 57.15 ? 83  TRP B CH2   1 
ATOM   2465 N N     . LEU C 1 67  ? -29.544 -14.336 78.549 1.00 35.10 ? 84  LEU B N     1 
ATOM   2466 C CA    . LEU C 1 67  ? -29.679 -14.148 77.112 1.00 33.37 ? 84  LEU B CA    1 
ATOM   2467 C C     . LEU C 1 67  ? -28.390 -14.526 76.377 1.00 35.16 ? 84  LEU B C     1 
ATOM   2468 O O     . LEU C 1 67  ? -28.436 -15.154 75.310 1.00 34.06 ? 84  LEU B O     1 
ATOM   2469 C CB    . LEU C 1 67  ? -30.075 -12.693 76.852 1.00 35.48 ? 84  LEU B CB    1 
ATOM   2470 C CG    . LEU C 1 67  ? -30.275 -12.169 75.439 1.00 37.62 ? 84  LEU B CG    1 
ATOM   2471 C CD1   . LEU C 1 67  ? -31.450 -12.885 74.867 1.00 36.23 ? 84  LEU B CD1   1 
ATOM   2472 C CD2   . LEU C 1 67  ? -30.553 -10.675 75.474 1.00 39.71 ? 84  LEU B CD2   1 
ATOM   2473 N N     . GLN C 1 68  ? -27.226 -14.158 76.933 1.00 38.00 ? 85  GLN B N     1 
ATOM   2474 C CA    . GLN C 1 68  ? -25.952 -14.506 76.294 1.00 39.56 ? 85  GLN B CA    1 
ATOM   2475 C C     . GLN C 1 68  ? -25.736 -16.012 76.267 1.00 37.60 ? 85  GLN B C     1 
ATOM   2476 O O     . GLN C 1 68  ? -25.176 -16.551 75.305 1.00 39.09 ? 85  GLN B O     1 
ATOM   2477 C CB    . GLN C 1 68  ? -24.775 -13.834 77.010 1.00 41.03 ? 85  GLN B CB    1 
ATOM   2478 C CG    . GLN C 1 68  ? -24.992 -12.373 77.342 1.00 47.06 ? 85  GLN B CG    1 
ATOM   2479 C CD    . GLN C 1 68  ? -23.724 -11.611 77.654 1.00 55.18 ? 85  GLN B CD    1 
ATOM   2480 O OE1   . GLN C 1 68  ? -23.780 -10.507 78.198 1.00 58.60 ? 85  GLN B OE1   1 
ATOM   2481 N NE2   . GLN C 1 68  ? -22.577 -12.188 77.316 1.00 52.70 ? 85  GLN B NE2   1 
ATOM   2482 N N     . GLN C 1 69  ? -26.150 -16.702 77.331 1.00 37.29 ? 86  GLN B N     1 
ATOM   2483 C CA    . GLN C 1 69  ? -25.997 -18.152 77.396 1.00 39.37 ? 86  GLN B CA    1 
ATOM   2484 C C     . GLN C 1 69  ? -26.952 -18.880 76.463 1.00 37.08 ? 86  GLN B C     1 
ATOM   2485 O O     . GLN C 1 69  ? -26.729 -20.056 76.166 1.00 35.42 ? 86  GLN B O     1 
ATOM   2486 C CB    . GLN C 1 69  ? -26.239 -18.648 78.815 1.00 40.55 ? 86  GLN B CB    1 
ATOM   2487 C CG    . GLN C 1 69  ? -25.267 -18.139 79.855 1.00 49.44 ? 86  GLN B CG    1 
ATOM   2488 C CD    . GLN C 1 69  ? -25.720 -18.503 81.261 1.00 61.06 ? 86  GLN B CD    1 
ATOM   2489 O OE1   . GLN C 1 69  ? -25.842 -17.638 82.131 1.00 61.70 ? 86  GLN B OE1   1 
ATOM   2490 N NE2   . GLN C 1 69  ? -25.983 -19.789 81.486 1.00 64.66 ? 86  GLN B NE2   1 
ATOM   2491 N N     . ALA C 1 70  ? -28.010 -18.216 76.010 1.00 33.91 ? 87  ALA B N     1 
ATOM   2492 C CA    . ALA C 1 70  ? -29.082 -18.893 75.290 1.00 30.39 ? 87  ALA B CA    1 
ATOM   2493 C C     . ALA C 1 70  ? -28.607 -19.420 73.943 1.00 31.30 ? 87  ALA B C     1 
ATOM   2494 O O     . ALA C 1 70  ? -27.804 -18.787 73.253 1.00 31.97 ? 87  ALA B O     1 
ATOM   2495 C CB    . ALA C 1 70  ? -30.256 -17.939 75.076 1.00 26.12 ? 87  ALA B CB    1 
ATOM   2496 N N     . ASP C 1 71  ? -29.136 -20.576 73.559 1.00 24.60 ? 88  ASP B N     1 
ATOM   2497 C CA    . ASP C 1 71  ? -28.940 -21.077 72.210 1.00 26.85 ? 88  ASP B CA    1 
ATOM   2498 C C     . ASP C 1 71  ? -30.003 -20.522 71.279 1.00 26.46 ? 88  ASP B C     1 
ATOM   2499 O O     . ASP C 1 71  ? -29.726 -20.239 70.110 1.00 27.12 ? 88  ASP B O     1 
ATOM   2500 C CB    . ASP C 1 71  ? -29.004 -22.600 72.223 1.00 30.27 ? 88  ASP B CB    1 
ATOM   2501 C CG    . ASP C 1 71  ? -27.753 -23.208 72.811 1.00 35.94 ? 88  ASP B CG    1 
ATOM   2502 O OD1   . ASP C 1 71  ? -26.717 -23.229 72.116 1.00 37.88 ? 88  ASP B OD1   1 
ATOM   2503 O OD2   . ASP C 1 71  ? -27.820 -23.647 73.993 1.00 31.00 ? 88  ASP B OD2   1 
ATOM   2504 N N     . VAL C 1 72  ? -31.214 -20.351 71.801 1.00 22.41 ? 89  VAL B N     1 
ATOM   2505 C CA    . VAL C 1 72  ? -32.351 -19.831 71.059 1.00 19.04 ? 89  VAL B CA    1 
ATOM   2506 C C     . VAL C 1 72  ? -33.051 -18.831 71.959 1.00 17.19 ? 89  VAL B C     1 
ATOM   2507 O O     . VAL C 1 72  ? -33.270 -19.100 73.148 1.00 19.09 ? 89  VAL B O     1 
ATOM   2508 C CB    . VAL C 1 72  ? -33.333 -20.944 70.635 1.00 22.24 ? 89  VAL B CB    1 
ATOM   2509 C CG1   . VAL C 1 72  ? -34.540 -20.338 69.911 1.00 20.72 ? 89  VAL B CG1   1 
ATOM   2510 C CG2   . VAL C 1 72  ? -32.643 -21.972 69.749 1.00 22.45 ? 89  VAL B CG2   1 
ATOM   2511 N N     . VAL C 1 73  ? -33.385 -17.679 71.402 1.00 16.26 ? 90  VAL B N     1 
ATOM   2512 C CA    . VAL C 1 73  ? -34.150 -16.648 72.097 1.00 17.06 ? 90  VAL B CA    1 
ATOM   2513 C C     . VAL C 1 73  ? -35.547 -16.667 71.505 1.00 20.62 ? 90  VAL B C     1 
ATOM   2514 O O     . VAL C 1 73  ? -35.713 -16.535 70.281 1.00 20.76 ? 90  VAL B O     1 
ATOM   2515 C CB    . VAL C 1 73  ? -33.501 -15.268 71.941 1.00 21.55 ? 90  VAL B CB    1 
ATOM   2516 C CG1   . VAL C 1 73  ? -34.389 -14.194 72.535 1.00 20.54 ? 90  VAL B CG1   1 
ATOM   2517 C CG2   . VAL C 1 73  ? -32.135 -15.274 72.583 1.00 20.65 ? 90  VAL B CG2   1 
ATOM   2518 N N     . VAL C 1 74  ? -36.544 -16.869 72.362 1.00 18.53 ? 91  VAL B N     1 
ATOM   2519 C CA    . VAL C 1 74  ? -37.946 -16.922 71.978 1.00 14.34 ? 91  VAL B CA    1 
ATOM   2520 C C     . VAL C 1 74  ? -38.651 -15.721 72.589 1.00 18.19 ? 91  VAL B C     1 
ATOM   2521 O O     . VAL C 1 74  ? -38.494 -15.446 73.786 1.00 17.59 ? 91  VAL B O     1 
ATOM   2522 C CB    . VAL C 1 74  ? -38.609 -18.225 72.467 1.00 15.55 ? 91  VAL B CB    1 
ATOM   2523 C CG1   . VAL C 1 74  ? -40.075 -18.259 72.077 1.00 17.35 ? 91  VAL B CG1   1 
ATOM   2524 C CG2   . VAL C 1 74  ? -37.858 -19.434 71.893 1.00 16.01 ? 91  VAL B CG2   1 
ATOM   2525 N N     . ALA C 1 75  ? -39.482 -15.060 71.793 1.00 17.42 ? 92  ALA B N     1 
ATOM   2526 C CA    . ALA C 1 75  ? -40.194 -13.876 72.249 1.00 17.23 ? 92  ALA B CA    1 
ATOM   2527 C C     . ALA C 1 75  ? -41.628 -13.937 71.759 1.00 20.13 ? 92  ALA B C     1 
ATOM   2528 O O     . ALA C 1 75  ? -41.872 -14.218 70.584 1.00 19.24 ? 92  ALA B O     1 
ATOM   2529 C CB    . ALA C 1 75  ? -39.513 -12.594 71.722 1.00 15.83 ? 92  ALA B CB    1 
ATOM   2530 N N     . GLU C 1 76  ? -42.580 -13.667 72.647 1.00 18.26 ? 93  GLU B N     1 
ATOM   2531 C CA    . GLU C 1 76  ? -43.957 -13.458 72.228 1.00 17.31 ? 93  GLU B CA    1 
ATOM   2532 C C     . GLU C 1 76  ? -44.093 -11.949 71.998 1.00 20.42 ? 93  GLU B C     1 
ATOM   2533 O O     . GLU C 1 76  ? -43.951 -11.158 72.942 1.00 19.76 ? 93  GLU B O     1 
ATOM   2534 C CB    . GLU C 1 76  ? -44.928 -14.002 73.284 1.00 18.63 ? 93  GLU B CB    1 
ATOM   2535 C CG    . GLU C 1 76  ? -46.216 -14.600 72.681 1.00 19.36 ? 93  GLU B CG    1 
ATOM   2536 C CD    . GLU C 1 76  ? -47.118 -13.572 72.005 1.00 23.73 ? 93  GLU B CD    1 
ATOM   2537 O OE1   . GLU C 1 76  ? -46.948 -12.357 72.252 1.00 22.62 ? 93  GLU B OE1   1 
ATOM   2538 O OE2   . GLU C 1 76  ? -48.018 -13.984 71.239 1.00 23.86 ? 93  GLU B OE2   1 
ATOM   2539 N N     . VAL C 1 77  ? -44.306 -11.541 70.742 1.00 18.18 ? 94  VAL B N     1 
ATOM   2540 C CA    . VAL C 1 77  ? -44.161 -10.129 70.361 1.00 18.66 ? 94  VAL B CA    1 
ATOM   2541 C C     . VAL C 1 77  ? -45.512 -9.470  70.065 1.00 19.26 ? 94  VAL B C     1 
ATOM   2542 O O     . VAL C 1 77  ? -45.564 -8.457  69.376 1.00 20.46 ? 94  VAL B O     1 
ATOM   2543 C CB    . VAL C 1 77  ? -43.199 -9.956  69.166 1.00 16.37 ? 94  VAL B CB    1 
ATOM   2544 C CG1   . VAL C 1 77  ? -41.767 -10.280 69.595 1.00 17.53 ? 94  VAL B CG1   1 
ATOM   2545 C CG2   . VAL C 1 77  ? -43.649 -10.782 67.943 1.00 16.72 ? 94  VAL B CG2   1 
ATOM   2546 N N     . THR C 1 78  ? -46.612 -10.042 70.542 1.00 17.96 ? 95  THR B N     1 
ATOM   2547 C CA    . THR C 1 78  ? -47.919 -9.461  70.246 1.00 18.82 ? 95  THR B CA    1 
ATOM   2548 C C     . THR C 1 78  ? -48.099 -8.140  70.980 1.00 23.81 ? 95  THR B C     1 
ATOM   2549 O O     . THR C 1 78  ? -48.617 -7.174  70.414 1.00 22.03 ? 95  THR B O     1 
ATOM   2550 C CB    . THR C 1 78  ? -49.014 -10.457 70.619 1.00 23.10 ? 95  THR B CB    1 
ATOM   2551 O OG1   . THR C 1 78  ? -48.783 -11.683 69.907 1.00 22.52 ? 95  THR B OG1   1 
ATOM   2552 C CG2   . THR C 1 78  ? -50.384 -9.907  70.256 1.00 23.90 ? 95  THR B CG2   1 
ATOM   2553 N N     . GLN C 1 79  ? -47.630 -8.069  72.219 1.00 21.04 ? 96  GLN B N     1 
ATOM   2554 C CA    . GLN C 1 79  ? -47.724 -6.843  73.006 1.00 27.72 ? 96  GLN B CA    1 
ATOM   2555 C C     . GLN C 1 79  ? -46.491 -5.987  72.778 1.00 29.13 ? 96  GLN B C     1 
ATOM   2556 O O     . GLN C 1 79  ? -45.371 -6.451  73.048 1.00 26.92 ? 96  GLN B O     1 
ATOM   2557 C CB    . GLN C 1 79  ? -47.860 -7.164  74.484 1.00 32.22 ? 96  GLN B CB    1 
ATOM   2558 C CG    . GLN C 1 79  ? -48.387 -5.991  75.319 1.00 41.52 ? 96  GLN B CG    1 
ATOM   2559 C CD    . GLN C 1 79  ? -49.803 -5.561  74.938 1.00 39.99 ? 96  GLN B CD    1 
ATOM   2560 O OE1   . GLN C 1 79  ? -50.561 -6.323  74.323 1.00 37.89 ? 96  GLN B OE1   1 
ATOM   2561 N NE2   . GLN C 1 79  ? -50.160 -4.321  75.300 1.00 39.01 ? 96  GLN B NE2   1 
ATOM   2562 N N     . PRO C 1 80  ? -46.638 -4.751  72.315 1.00 23.82 ? 97  PRO B N     1 
ATOM   2563 C CA    . PRO C 1 80  ? -45.476 -3.860  72.197 1.00 23.14 ? 97  PRO B CA    1 
ATOM   2564 C C     . PRO C 1 80  ? -44.744 -3.758  73.523 1.00 25.49 ? 97  PRO B C     1 
ATOM   2565 O O     . PRO C 1 80  ? -45.353 -3.560  74.577 1.00 26.58 ? 97  PRO B O     1 
ATOM   2566 C CB    . PRO C 1 80  ? -46.112 -2.524  71.806 1.00 24.42 ? 97  PRO B CB    1 
ATOM   2567 C CG    . PRO C 1 80  ? -47.307 -2.941  71.015 1.00 27.47 ? 97  PRO B CG    1 
ATOM   2568 C CD    . PRO C 1 80  ? -47.868 -4.080  71.867 1.00 27.60 ? 97  PRO B CD    1 
ATOM   2569 N N     . SER C 1 81  ? -43.429 -3.906  73.475 1.00 19.49 ? 98  SER B N     1 
ATOM   2570 C CA    . SER C 1 81  ? -42.647 -3.921  74.704 1.00 21.91 ? 98  SER B CA    1 
ATOM   2571 C C     . SER C 1 81  ? -41.254 -3.427  74.384 1.00 20.33 ? 98  SER B C     1 
ATOM   2572 O O     . SER C 1 81  ? -40.574 -4.004  73.523 1.00 19.72 ? 98  SER B O     1 
ATOM   2573 C CB    . SER C 1 81  ? -42.576 -5.320  75.323 1.00 24.67 ? 98  SER B CB    1 
ATOM   2574 O OG    . SER C 1 81  ? -41.536 -5.367  76.301 1.00 22.50 ? 98  SER B OG    1 
ATOM   2575 N N     . LEU C 1 82  ? -40.823 -2.389  75.098 1.00 19.16 ? 99  LEU B N     1 
ATOM   2576 C CA    . LEU C 1 82  ? -39.463 -1.915  74.916 1.00 19.81 ? 99  LEU B CA    1 
ATOM   2577 C C     . LEU C 1 82  ? -38.477 -2.980  75.335 1.00 20.86 ? 99  LEU B C     1 
ATOM   2578 O O     . LEU C 1 82  ? -37.451 -3.187  74.673 1.00 19.29 ? 99  LEU B O     1 
ATOM   2579 C CB    . LEU C 1 82  ? -39.220 -0.640  75.725 1.00 17.89 ? 99  LEU B CB    1 
ATOM   2580 C CG    . LEU C 1 82  ? -40.031 0.605   75.406 1.00 21.24 ? 99  LEU B CG    1 
ATOM   2581 C CD1   . LEU C 1 82  ? -39.853 1.552   76.579 1.00 22.49 ? 99  LEU B CD1   1 
ATOM   2582 C CD2   . LEU C 1 82  ? -39.535 1.246   74.118 1.00 20.62 ? 99  LEU B CD2   1 
ATOM   2583 N N     . GLY C 1 83  ? -38.777 -3.672  76.433 1.00 19.77 ? 100 GLY B N     1 
ATOM   2584 C CA    . GLY C 1 83  ? -37.840 -4.658  76.938 1.00 22.76 ? 100 GLY B CA    1 
ATOM   2585 C C     . GLY C 1 83  ? -37.661 -5.805  75.967 1.00 21.04 ? 100 GLY B C     1 
ATOM   2586 O O     . GLY C 1 83  ? -36.537 -6.222  75.676 1.00 21.60 ? 100 GLY B O     1 
ATOM   2587 N N     . VAL C 1 84  ? -38.774 -6.328  75.451 1.00 20.21 ? 101 VAL B N     1 
ATOM   2588 C CA    . VAL C 1 84  ? -38.686 -7.432  74.504 1.00 20.23 ? 101 VAL B CA    1 
ATOM   2589 C C     . VAL C 1 84  ? -37.968 -6.990  73.240 1.00 19.64 ? 101 VAL B C     1 
ATOM   2590 O O     . VAL C 1 84  ? -37.083 -7.692  72.735 1.00 16.58 ? 101 VAL B O     1 
ATOM   2591 C CB    . VAL C 1 84  ? -40.086 -7.994  74.210 1.00 21.37 ? 101 VAL B CB    1 
ATOM   2592 C CG1   . VAL C 1 84  ? -40.029 -8.995  73.039 1.00 21.32 ? 101 VAL B CG1   1 
ATOM   2593 C CG2   . VAL C 1 84  ? -40.635 -8.661  75.491 1.00 21.98 ? 101 VAL B CG2   1 
ATOM   2594 N N     . GLY C 1 85  ? -38.299 -5.805  72.735 1.00 19.29 ? 102 GLY B N     1 
ATOM   2595 C CA    . GLY C 1 85  ? -37.564 -5.291  71.587 1.00 18.19 ? 102 GLY B CA    1 
ATOM   2596 C C     . GLY C 1 85  ? -36.080 -5.181  71.875 1.00 16.36 ? 102 GLY B C     1 
ATOM   2597 O O     . GLY C 1 85  ? -35.246 -5.600  71.071 1.00 16.17 ? 102 GLY B O     1 
ATOM   2598 N N     . TYR C 1 86  ? -35.732 -4.665  73.056 1.00 16.62 ? 103 TYR B N     1 
ATOM   2599 C CA    . TYR C 1 86  ? -34.334 -4.491  73.414 1.00 17.80 ? 103 TYR B CA    1 
ATOM   2600 C C     . TYR C 1 86  ? -33.610 -5.827  73.447 1.00 18.95 ? 103 TYR B C     1 
ATOM   2601 O O     . TYR C 1 86  ? -32.506 -5.961  72.900 1.00 19.38 ? 103 TYR B O     1 
ATOM   2602 C CB    . TYR C 1 86  ? -34.232 -3.806  74.774 1.00 17.34 ? 103 TYR B CB    1 
ATOM   2603 C CG    . TYR C 1 86  ? -32.820 -3.638  75.247 1.00 20.95 ? 103 TYR B CG    1 
ATOM   2604 C CD1   . TYR C 1 86  ? -32.017 -2.627  74.734 1.00 19.73 ? 103 TYR B CD1   1 
ATOM   2605 C CD2   . TYR C 1 86  ? -32.287 -4.485  76.211 1.00 25.98 ? 103 TYR B CD2   1 
ATOM   2606 C CE1   . TYR C 1 86  ? -30.713 -2.460  75.173 1.00 23.51 ? 103 TYR B CE1   1 
ATOM   2607 C CE2   . TYR C 1 86  ? -30.996 -4.334  76.652 1.00 25.86 ? 103 TYR B CE2   1 
ATOM   2608 C CZ    . TYR C 1 86  ? -30.211 -3.325  76.137 1.00 25.18 ? 103 TYR B CZ    1 
ATOM   2609 O OH    . TYR C 1 86  ? -28.920 -3.199  76.595 1.00 30.57 ? 103 TYR B OH    1 
ATOM   2610 N N     . GLU C 1 87  ? -34.219 -6.825  74.106 1.00 17.85 ? 104 GLU B N     1 
ATOM   2611 C CA    . GLU C 1 87  ? -33.619 -8.152  74.171 1.00 18.87 ? 104 GLU B CA    1 
ATOM   2612 C C     . GLU C 1 87  ? -33.445 -8.754  72.784 1.00 18.11 ? 104 GLU B C     1 
ATOM   2613 O O     . GLU C 1 87  ? -32.440 -9.425  72.521 1.00 19.63 ? 104 GLU B O     1 
ATOM   2614 C CB    . GLU C 1 87  ? -34.461 -9.075  75.063 1.00 21.79 ? 104 GLU B CB    1 
ATOM   2615 C CG    . GLU C 1 87  ? -34.249 -8.782  76.548 1.00 25.65 ? 104 GLU B CG    1 
ATOM   2616 C CD    . GLU C 1 87  ? -35.332 -9.302  77.474 1.00 32.92 ? 104 GLU B CD    1 
ATOM   2617 O OE1   . GLU C 1 87  ? -36.530 -9.328  77.115 1.00 31.26 ? 104 GLU B OE1   1 
ATOM   2618 O OE2   . GLU C 1 87  ? -34.954 -9.695  78.600 1.00 41.90 ? 104 GLU B OE2   1 
ATOM   2619 N N     . LEU C 1 88  ? -34.411 -8.530  71.884 1.00 16.80 ? 105 LEU B N     1 
ATOM   2620 C CA    . LEU C 1 88  ? -34.295 -9.044  70.516 1.00 17.43 ? 105 LEU B CA    1 
ATOM   2621 C C     . LEU C 1 88  ? -33.153 -8.367  69.771 1.00 18.88 ? 105 LEU B C     1 
ATOM   2622 O O     . LEU C 1 88  ? -32.418 -9.018  69.016 1.00 19.96 ? 105 LEU B O     1 
ATOM   2623 C CB    . LEU C 1 88  ? -35.620 -8.848  69.763 1.00 17.53 ? 105 LEU B CB    1 
ATOM   2624 C CG    . LEU C 1 88  ? -36.736 -9.810  70.203 1.00 17.61 ? 105 LEU B CG    1 
ATOM   2625 C CD1   . LEU C 1 88  ? -38.092 -9.510  69.565 1.00 14.61 ? 105 LEU B CD1   1 
ATOM   2626 C CD2   . LEU C 1 88  ? -36.276 -11.261 69.901 1.00 19.81 ? 105 LEU B CD2   1 
ATOM   2627 N N     . GLY C 1 89  ? -32.989 -7.062  69.977 1.00 15.41 ? 106 GLY B N     1 
ATOM   2628 C CA    . GLY C 1 89  ? -31.896 -6.346  69.347 1.00 16.06 ? 106 GLY B CA    1 
ATOM   2629 C C     . GLY C 1 89  ? -30.539 -6.763  69.882 1.00 21.83 ? 106 GLY B C     1 
ATOM   2630 O O     . GLY C 1 89  ? -29.581 -6.915  69.116 1.00 20.71 ? 106 GLY B O     1 
ATOM   2631 N N     . ARG C 1 90  ? -30.435 -6.953  71.201 1.00 19.42 ? 107 ARG B N     1 
ATOM   2632 C CA    . ARG C 1 90  ? -29.209 -7.523  71.748 1.00 19.68 ? 107 ARG B CA    1 
ATOM   2633 C C     . ARG C 1 90  ? -28.988 -8.924  71.196 1.00 22.74 ? 107 ARG B C     1 
ATOM   2634 O O     . ARG C 1 90  ? -27.860 -9.288  70.858 1.00 24.84 ? 107 ARG B O     1 
ATOM   2635 C CB    . ARG C 1 90  ? -29.262 -7.564  73.276 1.00 22.66 ? 107 ARG B CB    1 
ATOM   2636 C CG    . ARG C 1 90  ? -29.378 -6.197  73.964 1.00 23.99 ? 107 ARG B CG    1 
ATOM   2637 C CD    . ARG C 1 90  ? -28.254 -5.245  73.605 1.00 22.31 ? 107 ARG B CD    1 
ATOM   2638 N NE    . ARG C 1 90  ? -26.914 -5.794  73.788 1.00 25.84 ? 107 ARG B NE    1 
ATOM   2639 C CZ    . ARG C 1 90  ? -26.186 -5.585  74.872 1.00 31.17 ? 107 ARG B CZ    1 
ATOM   2640 N NH1   . ARG C 1 90  ? -26.674 -4.913  75.904 1.00 34.12 ? 107 ARG B NH1   1 
ATOM   2641 N NH2   . ARG C 1 90  ? -24.936 -6.043  74.919 1.00 30.71 ? 107 ARG B NH2   1 
ATOM   2642 N N     . ALA C 1 91  ? -30.058 -9.717  71.084 1.00 19.95 ? 108 ALA B N     1 
ATOM   2643 C CA    . ALA C 1 91  ? -29.909 -11.103 70.636 1.00 20.62 ? 108 ALA B CA    1 
ATOM   2644 C C     . ALA C 1 91  ? -29.416 -11.173 69.202 1.00 24.74 ? 108 ALA B C     1 
ATOM   2645 O O     . ALA C 1 91  ? -28.559 -12.003 68.871 1.00 23.69 ? 108 ALA B O     1 
ATOM   2646 C CB    . ALA C 1 91  ? -31.233 -11.848 70.775 1.00 19.32 ? 108 ALA B CB    1 
ATOM   2647 N N     . VAL C 1 92  ? -29.950 -10.315 68.333 1.00 21.95 ? 109 VAL B N     1 
ATOM   2648 C CA    . VAL C 1 92  ? -29.479 -10.283 66.948 1.00 23.67 ? 109 VAL B CA    1 
ATOM   2649 C C     . VAL C 1 92  ? -27.985 -10.010 66.910 1.00 27.74 ? 109 VAL B C     1 
ATOM   2650 O O     . VAL C 1 92  ? -27.221 -10.704 66.230 1.00 25.08 ? 109 VAL B O     1 
ATOM   2651 C CB    . VAL C 1 92  ? -30.251 -9.234  66.135 1.00 23.42 ? 109 VAL B CB    1 
ATOM   2652 C CG1   . VAL C 1 92  ? -29.608 -9.078  64.743 1.00 28.55 ? 109 VAL B CG1   1 
ATOM   2653 C CG2   . VAL C 1 92  ? -31.659 -9.648  66.001 1.00 24.88 ? 109 VAL B CG2   1 
ATOM   2654 N N     . ALA C 1 93  ? -27.544 -9.012  67.667 1.00 27.88 ? 110 ALA B N     1 
ATOM   2655 C CA    . ALA C 1 93  ? -26.133 -8.664  67.680 1.00 29.36 ? 110 ALA B CA    1 
ATOM   2656 C C     . ALA C 1 93  ? -25.280 -9.757  68.307 1.00 30.53 ? 110 ALA B C     1 
ATOM   2657 O O     . ALA C 1 93  ? -24.086 -9.847  68.009 1.00 29.25 ? 110 ALA B O     1 
ATOM   2658 C CB    . ALA C 1 93  ? -25.944 -7.350  68.420 1.00 30.84 ? 110 ALA B CB    1 
ATOM   2659 N N     . PHE C 1 94  ? -25.860 -10.579 69.183 1.00 28.63 ? 111 PHE B N     1 
ATOM   2660 C CA    . PHE C 1 94  ? -25.165 -11.754 69.694 1.00 32.21 ? 111 PHE B CA    1 
ATOM   2661 C C     . PHE C 1 94  ? -25.191 -12.913 68.708 1.00 29.00 ? 111 PHE B C     1 
ATOM   2662 O O     . PHE C 1 94  ? -24.684 -13.988 69.042 1.00 32.60 ? 111 PHE B O     1 
ATOM   2663 C CB    . PHE C 1 94  ? -25.786 -12.225 71.017 1.00 29.98 ? 111 PHE B CB    1 
ATOM   2664 C CG    . PHE C 1 94  ? -25.496 -11.332 72.199 1.00 33.30 ? 111 PHE B CG    1 
ATOM   2665 C CD1   . PHE C 1 94  ? -24.236 -10.789 72.390 1.00 38.56 ? 111 PHE B CD1   1 
ATOM   2666 C CD2   . PHE C 1 94  ? -26.480 -11.083 73.152 1.00 33.63 ? 111 PHE B CD2   1 
ATOM   2667 C CE1   . PHE C 1 94  ? -23.971 -9.984  73.482 1.00 35.54 ? 111 PHE B CE1   1 
ATOM   2668 C CE2   . PHE C 1 94  ? -26.220 -10.275 74.252 1.00 36.27 ? 111 PHE B CE2   1 
ATOM   2669 C CZ    . PHE C 1 94  ? -24.963 -9.727  74.416 1.00 37.29 ? 111 PHE B CZ    1 
ATOM   2670 N N     . ASN C 1 95  ? -25.791 -12.724 67.530 1.00 29.66 ? 112 ASN B N     1 
ATOM   2671 C CA    A ASN C 1 95  ? -25.932 -13.776 66.520 0.57 28.83 ? 112 ASN B CA    1 
ATOM   2672 C CA    B ASN C 1 95  ? -25.914 -13.784 66.526 0.43 30.06 ? 112 ASN B CA    1 
ATOM   2673 C C     . ASN C 1 95  ? -26.680 -14.990 67.074 1.00 31.51 ? 112 ASN B C     1 
ATOM   2674 O O     . ASN C 1 95  ? -26.375 -16.140 66.748 1.00 28.87 ? 112 ASN B O     1 
ATOM   2675 C CB    A ASN C 1 95  ? -24.569 -14.185 65.955 0.57 34.51 ? 112 ASN B CB    1 
ATOM   2676 C CB    B ASN C 1 95  ? -24.540 -14.214 66.000 0.43 35.90 ? 112 ASN B CB    1 
ATOM   2677 C CG    A ASN C 1 95  ? -24.656 -14.663 64.520 0.57 34.59 ? 112 ASN B CG    1 
ATOM   2678 C CG    B ASN C 1 95  ? -23.626 -13.039 65.724 0.43 33.52 ? 112 ASN B CG    1 
ATOM   2679 O OD1   A ASN C 1 95  ? -25.688 -14.513 63.861 0.57 36.44 ? 112 ASN B OD1   1 
ATOM   2680 O OD1   B ASN C 1 95  ? -24.040 -12.043 65.130 0.43 37.45 ? 112 ASN B OD1   1 
ATOM   2681 N ND2   A ASN C 1 95  ? -23.572 -15.245 64.030 0.57 35.50 ? 112 ASN B ND2   1 
ATOM   2682 N ND2   B ASN C 1 95  ? -22.373 -13.148 66.153 0.43 34.66 ? 112 ASN B ND2   1 
ATOM   2683 N N     . LYS C 1 96  ? -27.677 -14.738 67.921 1.00 25.62 ? 113 LYS B N     1 
ATOM   2684 C CA    . LYS C 1 96  ? -28.464 -15.836 68.464 1.00 24.30 ? 113 LYS B CA    1 
ATOM   2685 C C     . LYS C 1 96  ? -29.495 -16.306 67.443 1.00 22.72 ? 113 LYS B C     1 
ATOM   2686 O O     . LYS C 1 96  ? -29.929 -15.544 66.574 1.00 27.92 ? 113 LYS B O     1 
ATOM   2687 C CB    . LYS C 1 96  ? -29.183 -15.414 69.753 1.00 25.32 ? 113 LYS B CB    1 
ATOM   2688 C CG    . LYS C 1 96  ? -28.269 -14.958 70.883 1.00 28.28 ? 113 LYS B CG    1 
ATOM   2689 C CD    . LYS C 1 96  ? -27.417 -16.108 71.368 1.00 28.36 ? 113 LYS B CD    1 
ATOM   2690 C CE    . LYS C 1 96  ? -26.672 -15.751 72.642 1.00 34.20 ? 113 LYS B CE    1 
ATOM   2691 N NZ    . LYS C 1 96  ? -25.873 -16.906 73.173 1.00 36.98 ? 113 LYS B NZ    1 
ATOM   2692 N N     . ARG C 1 97  ? -29.910 -17.562 67.564 1.00 21.75 ? 114 ARG B N     1 
ATOM   2693 C CA    . ARG C 1 97  ? -31.111 -17.984 66.855 1.00 21.53 ? 114 ARG B CA    1 
ATOM   2694 C C     . ARG C 1 97  ? -32.328 -17.413 67.573 1.00 21.55 ? 114 ARG B C     1 
ATOM   2695 O O     . ARG C 1 97  ? -32.417 -17.473 68.799 1.00 21.74 ? 114 ARG B O     1 
ATOM   2696 C CB    . ARG C 1 97  ? -31.222 -19.503 66.802 1.00 26.92 ? 114 ARG B CB    1 
ATOM   2697 C CG    . ARG C 1 97  ? -30.299 -20.165 65.813 1.00 30.27 ? 114 ARG B CG    1 
ATOM   2698 C CD    . ARG C 1 97  ? -30.724 -21.601 65.621 1.00 33.54 ? 114 ARG B CD    1 
ATOM   2699 N NE    . ARG C 1 97  ? -30.083 -22.458 66.609 1.00 40.17 ? 114 ARG B NE    1 
ATOM   2700 C CZ    . ARG C 1 97  ? -30.693 -23.467 67.215 1.00 44.99 ? 114 ARG B CZ    1 
ATOM   2701 N NH1   . ARG C 1 97  ? -31.934 -23.813 66.900 1.00 43.93 ? 114 ARG B NH1   1 
ATOM   2702 N NH2   . ARG C 1 97  ? -30.047 -24.138 68.168 1.00 42.17 ? 114 ARG B NH2   1 
ATOM   2703 N N     . ILE C 1 98  ? -33.272 -16.872 66.805 1.00 18.10 ? 115 ILE B N     1 
ATOM   2704 C CA    . ILE C 1 98  ? -34.386 -16.115 67.356 1.00 19.43 ? 115 ILE B CA    1 
ATOM   2705 C C     . ILE C 1 98  ? -35.679 -16.637 66.755 1.00 17.42 ? 115 ILE B C     1 
ATOM   2706 O O     . ILE C 1 98  ? -35.774 -16.858 65.542 1.00 19.29 ? 115 ILE B O     1 
ATOM   2707 C CB    . ILE C 1 98  ? -34.230 -14.591 67.102 1.00 17.23 ? 115 ILE B CB    1 
ATOM   2708 C CG1   . ILE C 1 98  ? -33.084 -14.033 67.942 1.00 22.79 ? 115 ILE B CG1   1 
ATOM   2709 C CG2   . ILE C 1 98  ? -35.521 -13.845 67.407 1.00 19.62 ? 115 ILE B CG2   1 
ATOM   2710 C CD1   . ILE C 1 98  ? -32.485 -12.787 67.371 1.00 24.30 ? 115 ILE B CD1   1 
ATOM   2711 N N     . LEU C 1 99  ? -36.679 -16.821 67.611 1.00 15.67 ? 116 LEU B N     1 
ATOM   2712 C CA    . LEU C 1 99  ? -38.027 -17.174 67.198 1.00 14.93 ? 116 LEU B CA    1 
ATOM   2713 C C     . LEU C 1 99  ? -38.997 -16.197 67.834 1.00 17.07 ? 116 LEU B C     1 
ATOM   2714 O O     . LEU C 1 99  ? -39.107 -16.164 69.061 1.00 17.77 ? 116 LEU B O     1 
ATOM   2715 C CB    . LEU C 1 99  ? -38.368 -18.590 67.652 1.00 18.37 ? 116 LEU B CB    1 
ATOM   2716 C CG    . LEU C 1 99  ? -39.837 -18.982 67.540 1.00 16.62 ? 116 LEU B CG    1 
ATOM   2717 C CD1   . LEU C 1 99  ? -40.283 -19.067 66.080 1.00 18.10 ? 116 LEU B CD1   1 
ATOM   2718 C CD2   . LEU C 1 99  ? -40.062 -20.297 68.252 1.00 17.46 ? 116 LEU B CD2   1 
ATOM   2719 N N     . CYS C 1 100 ? -39.708 -15.421 67.013 1.00 14.06 ? 117 CYS B N     1 
ATOM   2720 C CA    . CYS C 1 100 ? -40.734 -14.506 67.491 1.00 15.79 ? 117 CYS B CA    1 
ATOM   2721 C C     . CYS C 1 100 ? -42.117 -15.038 67.141 1.00 19.53 ? 117 CYS B C     1 
ATOM   2722 O O     . CYS C 1 100 ? -42.337 -15.542 66.033 1.00 18.73 ? 117 CYS B O     1 
ATOM   2723 C CB    . CYS C 1 100 ? -40.567 -13.120 66.866 1.00 20.92 ? 117 CYS B CB    1 
ATOM   2724 S SG    . CYS C 1 100 ? -39.078 -12.322 67.413 1.00 20.58 ? 117 CYS B SG    1 
ATOM   2725 N N     . LEU C 1 101 ? -43.055 -14.879 68.076 1.00 15.30 ? 118 LEU B N     1 
ATOM   2726 C CA    . LEU C 1 101 ? -44.426 -15.353 67.916 1.00 15.99 ? 118 LEU B CA    1 
ATOM   2727 C C     . LEU C 1 101 ? -45.368 -14.163 67.988 1.00 17.37 ? 118 LEU B C     1 
ATOM   2728 O O     . LEU C 1 101 ? -45.355 -13.424 68.973 1.00 18.76 ? 118 LEU B O     1 
ATOM   2729 C CB    . LEU C 1 101 ? -44.807 -16.369 69.002 1.00 20.02 ? 118 LEU B CB    1 
ATOM   2730 C CG    . LEU C 1 101 ? -43.774 -17.451 69.334 1.00 22.78 ? 118 LEU B CG    1 
ATOM   2731 C CD1   . LEU C 1 101 ? -44.218 -18.261 70.517 1.00 30.90 ? 118 LEU B CD1   1 
ATOM   2732 C CD2   . LEU C 1 101 ? -43.524 -18.309 68.111 1.00 26.40 ? 118 LEU B CD2   1 
ATOM   2733 N N     . PHE C 1 102 ? -46.208 -14.001 66.973 1.00 17.37 ? 119 PHE B N     1 
ATOM   2734 C CA    . PHE C 1 102 ? -47.090 -12.842 66.910 1.00 17.78 ? 119 PHE B CA    1 
ATOM   2735 C C     . PHE C 1 102 ? -48.520 -13.272 66.609 1.00 19.24 ? 119 PHE B C     1 
ATOM   2736 O O     . PHE C 1 102 ? -48.755 -14.115 65.738 1.00 19.97 ? 119 PHE B O     1 
ATOM   2737 C CB    . PHE C 1 102 ? -46.611 -11.869 65.845 1.00 17.60 ? 119 PHE B CB    1 
ATOM   2738 C CG    . PHE C 1 102 ? -47.517 -10.684 65.652 1.00 19.13 ? 119 PHE B CG    1 
ATOM   2739 C CD1   . PHE C 1 102 ? -47.524 -9.654  66.575 1.00 20.78 ? 119 PHE B CD1   1 
ATOM   2740 C CD2   . PHE C 1 102 ? -48.361 -10.609 64.555 1.00 20.39 ? 119 PHE B CD2   1 
ATOM   2741 C CE1   . PHE C 1 102 ? -48.346 -8.552  66.403 1.00 19.96 ? 119 PHE B CE1   1 
ATOM   2742 C CE2   . PHE C 1 102 ? -49.184 -9.497  64.371 1.00 23.49 ? 119 PHE B CE2   1 
ATOM   2743 C CZ    . PHE C 1 102 ? -49.184 -8.484  65.302 1.00 18.96 ? 119 PHE B CZ    1 
ATOM   2744 N N     . ARG C 1 103 ? -49.479 -12.678 67.320 1.00 17.29 ? 120 ARG B N     1 
ATOM   2745 C CA    . ARG C 1 103 ? -50.880 -12.992 67.085 1.00 23.07 ? 120 ARG B CA    1 
ATOM   2746 C C     . ARG C 1 103 ? -51.541 -11.855 66.318 1.00 22.25 ? 120 ARG B C     1 
ATOM   2747 O O     . ARG C 1 103 ? -51.915 -10.840 66.929 1.00 23.57 ? 120 ARG B O     1 
ATOM   2748 C CB    . ARG C 1 103 ? -51.595 -13.231 68.422 1.00 24.07 ? 120 ARG B CB    1 
ATOM   2749 C CG    . ARG C 1 103 ? -51.129 -14.497 69.084 1.00 25.78 ? 120 ARG B CG    1 
ATOM   2750 C CD    . ARG C 1 103 ? -51.886 -14.841 70.358 1.00 25.44 ? 120 ARG B CD    1 
ATOM   2751 N NE    . ARG C 1 103 ? -52.474 -13.686 71.031 1.00 33.58 ? 120 ARG B NE    1 
ATOM   2752 C CZ    . ARG C 1 103 ? -51.937 -13.058 72.070 1.00 35.30 ? 120 ARG B CZ    1 
ATOM   2753 N NH1   . ARG C 1 103 ? -50.718 -13.342 72.499 1.00 30.93 ? 120 ARG B NH1   1 
ATOM   2754 N NH2   . ARG C 1 103 ? -52.628 -12.102 72.677 1.00 36.61 ? 120 ARG B NH2   1 
ATOM   2755 N N     . PRO C 1 104 ? -51.730 -11.975 65.000 1.00 24.64 ? 121 PRO B N     1 
ATOM   2756 C CA    . PRO C 1 104 ? -52.373 -10.882 64.247 1.00 25.78 ? 121 PRO B CA    1 
ATOM   2757 C C     . PRO C 1 104 ? -53.812 -10.621 64.647 1.00 31.73 ? 121 PRO B C     1 
ATOM   2758 O O     . PRO C 1 104 ? -54.316 -9.513  64.420 1.00 33.45 ? 121 PRO B O     1 
ATOM   2759 C CB    . PRO C 1 104 ? -52.254 -11.353 62.789 1.00 30.32 ? 121 PRO B CB    1 
ATOM   2760 C CG    . PRO C 1 104 ? -52.165 -12.857 62.892 1.00 29.19 ? 121 PRO B CG    1 
ATOM   2761 C CD    . PRO C 1 104 ? -51.268 -13.050 64.101 1.00 24.21 ? 121 PRO B CD    1 
ATOM   2762 N N     . GLN C 1 105 ? -54.487 -11.585 65.263 1.00 24.43 ? 122 GLN B N     1 
ATOM   2763 C CA    . GLN C 1 105 ? -55.868 -11.358 65.666 1.00 31.44 ? 122 GLN B CA    1 
ATOM   2764 C C     . GLN C 1 105 ? -55.969 -10.387 66.824 1.00 32.13 ? 122 GLN B C     1 
ATOM   2765 O O     . GLN C 1 105 ? -57.084 -9.995  67.187 1.00 32.62 ? 122 GLN B O     1 
ATOM   2766 C CB    . GLN C 1 105 ? -56.496 -12.703 66.000 1.00 28.88 ? 122 GLN B CB    1 
ATOM   2767 C CG    . GLN C 1 105 ? -56.810 -13.445 64.723 1.00 30.82 ? 122 GLN B CG    1 
ATOM   2768 C CD    . GLN C 1 105 ? -57.263 -14.843 64.983 1.00 33.72 ? 122 GLN B CD    1 
ATOM   2769 O OE1   . GLN C 1 105 ? -57.773 -15.150 66.060 0.53 31.16 ? 122 GLN B OE1   1 
ATOM   2770 N NE2   . GLN C 1 105 ? -57.054 -15.719 64.007 0.82 34.16 ? 122 GLN B NE2   1 
ATOM   2771 N N     . SER C 1 106 ? -54.827 -10.001 67.400 1.00 29.57 ? 123 SER B N     1 
ATOM   2772 C CA    . SER C 1 106 ? -54.759 -8.897  68.347 1.00 32.31 ? 123 SER B CA    1 
ATOM   2773 C C     . SER C 1 106 ? -55.253 -7.594  67.736 1.00 33.13 ? 123 SER B C     1 
ATOM   2774 O O     . SER C 1 106 ? -55.575 -6.658  68.476 1.00 34.04 ? 123 SER B O     1 
ATOM   2775 C CB    . SER C 1 106 ? -53.314 -8.699  68.820 1.00 33.87 ? 123 SER B CB    1 
ATOM   2776 O OG    . SER C 1 106 ? -52.465 -8.308  67.733 1.00 28.57 ? 123 SER B OG    1 
ATOM   2777 N N     . GLY C 1 107 ? -55.295 -7.507  66.408 1.00 31.95 ? 124 GLY B N     1 
ATOM   2778 C CA    . GLY C 1 107 ? -55.652 -6.289  65.717 1.00 36.56 ? 124 GLY B CA    1 
ATOM   2779 C C     . GLY C 1 107 ? -54.499 -5.339  65.490 1.00 37.73 ? 124 GLY B C     1 
ATOM   2780 O O     . GLY C 1 107 ? -54.694 -4.290  64.855 1.00 36.58 ? 124 GLY B O     1 
ATOM   2781 N N     . ARG C 1 108 ? -53.310 -5.674  65.981 1.00 31.22 ? 125 ARG B N     1 
ATOM   2782 C CA    . ARG C 1 108 ? -52.133 -4.829  65.879 1.00 31.88 ? 125 ARG B CA    1 
ATOM   2783 C C     . ARG C 1 108 ? -51.365 -5.183  64.619 1.00 28.46 ? 125 ARG B C     1 
ATOM   2784 O O     . ARG C 1 108 ? -51.449 -6.302  64.104 1.00 30.44 ? 125 ARG B O     1 
ATOM   2785 C CB    . ARG C 1 108 ? -51.216 -5.032  67.087 1.00 32.63 ? 125 ARG B CB    1 
ATOM   2786 C CG    . ARG C 1 108 ? -51.838 -4.699  68.426 1.00 37.88 ? 125 ARG B CG    1 
ATOM   2787 C CD    . ARG C 1 108 ? -50.789 -4.622  69.513 1.00 37.60 ? 125 ARG B CD    1 
ATOM   2788 N NE    . ARG C 1 108 ? -51.204 -3.776  70.630 1.00 37.85 ? 125 ARG B NE    1 
ATOM   2789 C CZ    . ARG C 1 108 ? -50.835 -2.511  70.805 1.00 40.38 ? 125 ARG B CZ    1 
ATOM   2790 N NH1   . ARG C 1 108 ? -50.139 -1.855  69.887 1.00 41.72 ? 125 ARG B NH1   1 
ATOM   2791 N NH2   . ARG C 1 108 ? -51.175 -1.887  71.929 1.00 44.99 ? 125 ARG B NH2   1 
ATOM   2792 N N     . VAL C 1 109 ? -50.591 -4.222  64.129 1.00 26.70 ? 126 VAL B N     1 
ATOM   2793 C CA    . VAL C 1 109 ? -49.590 -4.499  63.111 1.00 25.14 ? 126 VAL B CA    1 
ATOM   2794 C C     . VAL C 1 109 ? -48.258 -4.667  63.826 1.00 22.12 ? 126 VAL B C     1 
ATOM   2795 O O     . VAL C 1 109 ? -47.830 -3.784  64.583 1.00 20.44 ? 126 VAL B O     1 
ATOM   2796 C CB    . VAL C 1 109 ? -49.527 -3.395  62.047 1.00 26.58 ? 126 VAL B CB    1 
ATOM   2797 C CG1   . VAL C 1 109 ? -48.552 -3.805  60.939 1.00 26.40 ? 126 VAL B CG1   1 
ATOM   2798 C CG2   . VAL C 1 109 ? -50.916 -3.152  61.465 1.00 34.54 ? 126 VAL B CG2   1 
ATOM   2799 N N     . LEU C 1 110 ? -47.619 -5.812  63.615 1.00 22.30 ? 127 LEU B N     1 
ATOM   2800 C CA    . LEU C 1 110 ? -46.299 -6.036  64.184 1.00 18.14 ? 127 LEU B CA    1 
ATOM   2801 C C     . LEU C 1 110 ? -45.323 -4.992  63.672 1.00 18.06 ? 127 LEU B C     1 
ATOM   2802 O O     . LEU C 1 110 ? -45.250 -4.736  62.467 1.00 19.85 ? 127 LEU B O     1 
ATOM   2803 C CB    . LEU C 1 110 ? -45.786 -7.435  63.823 1.00 17.67 ? 127 LEU B CB    1 
ATOM   2804 C CG    . LEU C 1 110 ? -44.407 -7.799  64.384 1.00 18.89 ? 127 LEU B CG    1 
ATOM   2805 C CD1   . LEU C 1 110 ? -44.274 -7.555  65.906 1.00 19.61 ? 127 LEU B CD1   1 
ATOM   2806 C CD2   . LEU C 1 110 ? -44.066 -9.242  64.043 1.00 18.19 ? 127 LEU B CD2   1 
ATOM   2807 N N     . SER C 1 111 ? -44.562 -4.420  64.601 1.00 16.69 ? 128 SER B N     1 
ATOM   2808 C CA    . SER C 1 111 ? -43.425 -3.549  64.312 1.00 18.29 ? 128 SER B CA    1 
ATOM   2809 C C     . SER C 1 111 ? -42.651 -3.978  63.070 1.00 19.67 ? 128 SER B C     1 
ATOM   2810 O O     . SER C 1 111 ? -42.235 -5.135  62.949 1.00 17.03 ? 128 SER B O     1 
ATOM   2811 C CB    . SER C 1 111 ? -42.478 -3.567  65.507 1.00 17.34 ? 128 SER B CB    1 
ATOM   2812 O OG    . SER C 1 111 ? -41.299 -2.838  65.230 1.00 18.10 ? 128 SER B OG    1 
ATOM   2813 N N     . ALA C 1 112 ? -42.417 -3.020  62.163 1.00 18.35 ? 129 ALA B N     1 
ATOM   2814 C CA    . ALA C 1 112 ? -41.558 -3.292  61.010 1.00 17.39 ? 129 ALA B CA    1 
ATOM   2815 C C     . ALA C 1 112 ? -40.142 -3.680  61.419 1.00 16.93 ? 129 ALA B C     1 
ATOM   2816 O O     . ALA C 1 112 ? -39.447 -4.368  60.660 1.00 19.69 ? 129 ALA B O     1 
ATOM   2817 C CB    . ALA C 1 112 ? -41.523 -2.074  60.086 1.00 20.39 ? 129 ALA B CB    1 
ATOM   2818 N N     . MET C 1 113 ? -39.678 -3.253  62.595 1.00 16.95 ? 130 MET B N     1 
ATOM   2819 C CA    . MET C 1 113 ? -38.301 -3.569  62.958 1.00 20.07 ? 130 MET B CA    1 
ATOM   2820 C C     . MET C 1 113 ? -38.159 -5.040  63.325 1.00 18.85 ? 130 MET B C     1 
ATOM   2821 O O     . MET C 1 113 ? -37.066 -5.607  63.213 1.00 21.40 ? 130 MET B O     1 
ATOM   2822 C CB    . MET C 1 113 ? -37.828 -2.675  64.103 1.00 19.61 ? 130 MET B CB    1 
ATOM   2823 C CG    . MET C 1 113 ? -37.815 -1.228  63.674 1.00 20.64 ? 130 MET B CG    1 
ATOM   2824 S SD    . MET C 1 113 ? -36.742 -0.847  62.248 1.00 23.97 ? 130 MET B SD    1 
ATOM   2825 C CE    . MET C 1 113 ? -35.189 -1.574  62.766 1.00 23.51 ? 130 MET B CE    1 
ATOM   2826 N N     . ILE C 1 114 ? -39.238 -5.666  63.780 1.00 18.72 ? 131 ILE B N     1 
ATOM   2827 C CA    . ILE C 1 114 ? -39.221 -7.086  64.096 1.00 18.56 ? 131 ILE B CA    1 
ATOM   2828 C C     . ILE C 1 114 ? -39.610 -7.905  62.873 1.00 17.04 ? 131 ILE B C     1 
ATOM   2829 O O     . ILE C 1 114 ? -38.913 -8.848  62.497 1.00 19.87 ? 131 ILE B O     1 
ATOM   2830 C CB    . ILE C 1 114 ? -40.152 -7.374  65.295 1.00 16.91 ? 131 ILE B CB    1 
ATOM   2831 C CG1   . ILE C 1 114 ? -39.719 -6.581  66.540 1.00 18.59 ? 131 ILE B CG1   1 
ATOM   2832 C CG2   . ILE C 1 114 ? -40.180 -8.904  65.604 1.00 15.53 ? 131 ILE B CG2   1 
ATOM   2833 C CD1   . ILE C 1 114 ? -38.255 -6.761  66.944 1.00 18.17 ? 131 ILE B CD1   1 
ATOM   2834 N N     . ARG C 1 115 ? -40.722 -7.540  62.233 1.00 19.39 ? 132 ARG B N     1 
ATOM   2835 C CA    . ARG C 1 115 ? -41.122 -8.188  60.990 1.00 20.53 ? 132 ARG B CA    1 
ATOM   2836 C C     . ARG C 1 115 ? -40.016 -8.112  59.955 1.00 19.53 ? 132 ARG B C     1 
ATOM   2837 O O     . ARG C 1 115 ? -39.724 -9.099  59.274 1.00 20.41 ? 132 ARG B O     1 
ATOM   2838 C CB    . ARG C 1 115 ? -42.389 -7.539  60.436 1.00 18.56 ? 132 ARG B CB    1 
ATOM   2839 C CG    . ARG C 1 115 ? -42.981 -8.211  59.214 1.00 21.52 ? 132 ARG B CG    1 
ATOM   2840 C CD    . ARG C 1 115 ? -43.659 -9.506  59.574 1.00 27.30 ? 132 ARG B CD    1 
ATOM   2841 N NE    . ARG C 1 115 ? -44.937 -9.288  60.247 1.00 24.21 ? 132 ARG B NE    1 
ATOM   2842 C CZ    . ARG C 1 115 ? -45.698 -10.268 60.714 1.00 25.51 ? 132 ARG B CZ    1 
ATOM   2843 N NH1   . ARG C 1 115 ? -45.357 -11.540 60.553 1.00 26.11 ? 132 ARG B NH1   1 
ATOM   2844 N NH2   . ARG C 1 115 ? -46.817 -9.964  61.370 1.00 23.10 ? 132 ARG B NH2   1 
ATOM   2845 N N     . GLY C 1 116 ? -39.400 -6.940  59.816 1.00 19.26 ? 133 GLY B N     1 
ATOM   2846 C CA    . GLY C 1 116 ? -38.371 -6.751  58.811 1.00 19.28 ? 133 GLY B CA    1 
ATOM   2847 C C     . GLY C 1 116 ? -37.041 -7.373  59.142 1.00 21.23 ? 133 GLY B C     1 
ATOM   2848 O O     . GLY C 1 116 ? -36.161 -7.419  58.281 1.00 20.92 ? 133 GLY B O     1 
ATOM   2849 N N     . ALA C 1 117 ? -36.856 -7.833  60.373 1.00 19.27 ? 134 ALA B N     1 
ATOM   2850 C CA    . ALA C 1 117 ? -35.632 -8.531  60.742 1.00 20.10 ? 134 ALA B CA    1 
ATOM   2851 C C     . ALA C 1 117 ? -35.678 -10.012 60.393 1.00 19.59 ? 134 ALA B C     1 
ATOM   2852 O O     . ALA C 1 117 ? -34.640 -10.685 60.436 1.00 23.63 ? 134 ALA B O     1 
ATOM   2853 C CB    . ALA C 1 117 ? -35.373 -8.369  62.241 1.00 21.93 ? 134 ALA B CB    1 
ATOM   2854 N N     . ALA C 1 118 ? -36.848 -10.526 60.046 1.00 21.04 ? 135 ALA B N     1 
ATOM   2855 C CA    . ALA C 1 118 ? -37.000 -11.957 59.831 1.00 23.62 ? 135 ALA B CA    1 
ATOM   2856 C C     . ALA C 1 118 ? -36.241 -12.380 58.587 1.00 26.69 ? 135 ALA B C     1 
ATOM   2857 O O     . ALA C 1 118 ? -36.245 -11.682 57.571 1.00 28.42 ? 135 ALA B O     1 
ATOM   2858 C CB    . ALA C 1 118 ? -38.475 -12.320 59.691 1.00 21.71 ? 135 ALA B CB    1 
ATOM   2859 N N     . ASP C 1 119 ? -35.566 -13.522 58.677 1.00 25.09 ? 136 ASP B N     1 
ATOM   2860 C CA    . ASP C 1 119 ? -35.009 -14.157 57.490 1.00 27.02 ? 136 ASP B CA    1 
ATOM   2861 C C     . ASP C 1 119 ? -35.526 -15.579 57.338 1.00 30.75 ? 136 ASP B C     1 
ATOM   2862 O O     . ASP C 1 119 ? -35.055 -16.311 56.459 1.00 31.15 ? 136 ASP B O     1 
ATOM   2863 C CB    . ASP C 1 119 ? -33.480 -14.147 57.530 1.00 28.96 ? 136 ASP B CB    1 
ATOM   2864 C CG    . ASP C 1 119 ? -32.910 -14.821 58.769 1.00 28.97 ? 136 ASP B CG    1 
ATOM   2865 O OD1   . ASP C 1 119 ? -31.695 -14.659 59.024 1.00 36.27 ? 136 ASP B OD1   1 
ATOM   2866 O OD2   . ASP C 1 119 ? -33.641 -15.577 59.439 1.00 25.33 ? 136 ASP B OD2   1 
ATOM   2867 N N     . GLY C 1 120 ? -36.466 -15.995 58.192 1.00 24.47 ? 137 GLY B N     1 
ATOM   2868 C CA    . GLY C 1 120 ? -37.053 -17.316 58.115 1.00 24.51 ? 137 GLY B CA    1 
ATOM   2869 C C     . GLY C 1 120 ? -36.164 -18.465 58.538 1.00 24.07 ? 137 GLY B C     1 
ATOM   2870 O O     . GLY C 1 120 ? -36.595 -19.618 58.445 1.00 24.84 ? 137 GLY B O     1 
ATOM   2871 N N     . SER C 1 121 ? -34.941 -18.198 58.998 1.00 22.63 ? 138 SER B N     1 
ATOM   2872 C CA    . SER C 1 121 ? -34.063 -19.256 59.484 1.00 24.56 ? 138 SER B CA    1 
ATOM   2873 C C     . SER C 1 121 ? -33.526 -18.883 60.861 1.00 23.66 ? 138 SER B C     1 
ATOM   2874 O O     . SER C 1 121 ? -34.055 -19.340 61.881 1.00 22.41 ? 138 SER B O     1 
ATOM   2875 C CB    . SER C 1 121 ? -32.912 -19.510 58.503 1.00 26.62 ? 138 SER B CB    1 
ATOM   2876 O OG    . SER C 1 121 ? -32.254 -18.289 58.195 1.00 35.45 ? 138 SER B OG    1 
ATOM   2877 N N     . ARG C 1 122 ? -32.488 -18.041 60.915 1.00 22.56 ? 139 ARG B N     1 
ATOM   2878 C CA    . ARG C 1 122 ? -31.946 -17.651 62.218 1.00 24.28 ? 139 ARG B CA    1 
ATOM   2879 C C     . ARG C 1 122 ? -32.777 -16.578 62.915 1.00 23.80 ? 139 ARG B C     1 
ATOM   2880 O O     . ARG C 1 122 ? -32.594 -16.356 64.116 1.00 23.83 ? 139 ARG B O     1 
ATOM   2881 C CB    . ARG C 1 122 ? -30.498 -17.168 62.077 1.00 28.49 ? 139 ARG B CB    1 
ATOM   2882 C CG    . ARG C 1 122 ? -29.513 -18.289 61.723 1.00 34.40 ? 139 ARG B CG    1 
ATOM   2883 C CD    . ARG C 1 122 ? -28.053 -17.858 61.897 1.00 36.19 ? 139 ARG B CD    1 
ATOM   2884 N NE    . ARG C 1 122 ? -27.640 -17.748 63.292 1.00 31.81 ? 139 ARG B NE    1 
ATOM   2885 C CZ    . ARG C 1 122 ? -27.291 -18.772 64.063 1.00 34.10 ? 139 ARG B CZ    1 
ATOM   2886 N NH1   . ARG C 1 122 ? -27.407 -20.027 63.648 1.00 31.09 ? 139 ARG B NH1   1 
ATOM   2887 N NH2   . ARG C 1 122 ? -26.826 -18.533 65.287 1.00 30.40 ? 139 ARG B NH2   1 
ATOM   2888 N N     . PHE C 1 123 ? -33.672 -15.907 62.199 1.00 21.09 ? 140 PHE B N     1 
ATOM   2889 C CA    . PHE C 1 123 ? -34.591 -14.915 62.790 1.00 19.68 ? 140 PHE B CA    1 
ATOM   2890 C C     . PHE C 1 123 ? -35.966 -15.219 62.226 1.00 19.89 ? 140 PHE B C     1 
ATOM   2891 O O     . PHE C 1 123 ? -36.326 -14.764 61.138 1.00 19.65 ? 140 PHE B O     1 
ATOM   2892 C CB    . PHE C 1 123 ? -34.171 -13.478 62.499 1.00 20.26 ? 140 PHE B CB    1 
ATOM   2893 C CG    . PHE C 1 123 ? -34.804 -12.444 63.433 1.00 19.82 ? 140 PHE B CG    1 
ATOM   2894 C CD1   . PHE C 1 123 ? -36.185 -12.322 63.526 1.00 21.03 ? 140 PHE B CD1   1 
ATOM   2895 C CD2   . PHE C 1 123 ? -34.022 -11.582 64.180 1.00 18.96 ? 140 PHE B CD2   1 
ATOM   2896 C CE1   . PHE C 1 123 ? -36.785 -11.375 64.372 1.00 21.34 ? 140 PHE B CE1   1 
ATOM   2897 C CE2   . PHE C 1 123 ? -34.622 -10.633 65.021 1.00 22.63 ? 140 PHE B CE2   1 
ATOM   2898 C CZ    . PHE C 1 123 ? -35.990 -10.530 65.108 1.00 21.35 ? 140 PHE B CZ    1 
ATOM   2899 N N     . GLN C 1 124 ? -36.736 -16.011 62.951 1.00 16.98 ? 141 GLN B N     1 
ATOM   2900 C CA    . GLN C 1 124 ? -38.050 -16.396 62.483 1.00 16.92 ? 141 GLN B CA    1 
ATOM   2901 C C     . GLN C 1 124 ? -39.101 -15.604 63.228 1.00 18.84 ? 141 GLN B C     1 
ATOM   2902 O O     . GLN C 1 124 ? -38.999 -15.409 64.439 1.00 17.68 ? 141 GLN B O     1 
ATOM   2903 C CB    . GLN C 1 124 ? -38.289 -17.889 62.680 1.00 16.58 ? 141 GLN B CB    1 
ATOM   2904 C CG    . GLN C 1 124 ? -37.606 -18.694 61.608 1.00 19.72 ? 141 GLN B CG    1 
ATOM   2905 C CD    . GLN C 1 124 ? -37.702 -20.165 61.871 1.00 19.94 ? 141 GLN B CD    1 
ATOM   2906 O OE1   . GLN C 1 124 ? -38.785 -20.680 62.120 1.00 22.05 ? 141 GLN B OE1   1 
ATOM   2907 N NE2   . GLN C 1 124 ? -36.565 -20.851 61.851 1.00 21.72 ? 141 GLN B NE2   1 
ATOM   2908 N N     . VAL C 1 125 ? -40.106 -15.160 62.489 1.00 16.43 ? 142 VAL B N     1 
ATOM   2909 C CA    . VAL C 1 125 ? -41.209 -14.370 63.003 1.00 19.50 ? 142 VAL B CA    1 
ATOM   2910 C C     . VAL C 1 125 ? -42.440 -15.015 62.410 1.00 19.67 ? 142 VAL B C     1 
ATOM   2911 O O     . VAL C 1 125 ? -42.654 -14.920 61.194 1.00 20.05 ? 142 VAL B O     1 
ATOM   2912 C CB    . VAL C 1 125 ? -41.119 -12.901 62.564 1.00 17.99 ? 142 VAL B CB    1 
ATOM   2913 C CG1   . VAL C 1 125 ? -42.398 -12.167 62.940 1.00 21.66 ? 142 VAL B CG1   1 
ATOM   2914 C CG2   . VAL C 1 125 ? -39.863 -12.228 63.104 1.00 21.17 ? 142 VAL B CG2   1 
ATOM   2915 N N     . TRP C 1 126 ? -43.248 -15.674 63.243 1.00 17.91 ? 143 TRP B N     1 
ATOM   2916 C CA    . TRP C 1 126 ? -44.431 -16.370 62.763 1.00 16.62 ? 143 TRP B CA    1 
ATOM   2917 C C     . TRP C 1 126 ? -45.691 -15.778 63.365 1.00 22.27 ? 143 TRP B C     1 
ATOM   2918 O O     . TRP C 1 126 ? -45.802 -15.666 64.590 1.00 19.41 ? 143 TRP B O     1 
ATOM   2919 C CB    . TRP C 1 126 ? -44.366 -17.858 63.097 1.00 17.77 ? 143 TRP B CB    1 
ATOM   2920 C CG    . TRP C 1 126 ? -43.211 -18.492 62.424 1.00 19.16 ? 143 TRP B CG    1 
ATOM   2921 C CD1   . TRP C 1 126 ? -42.199 -19.187 63.020 1.00 18.56 ? 143 TRP B CD1   1 
ATOM   2922 C CD2   . TRP C 1 126 ? -42.922 -18.472 61.024 1.00 18.37 ? 143 TRP B CD2   1 
ATOM   2923 N NE1   . TRP C 1 126 ? -41.303 -19.607 62.076 1.00 19.86 ? 143 TRP B NE1   1 
ATOM   2924 C CE2   . TRP C 1 126 ? -41.727 -19.193 60.839 1.00 17.48 ? 143 TRP B CE2   1 
ATOM   2925 C CE3   . TRP C 1 126 ? -43.554 -17.919 59.905 1.00 20.41 ? 143 TRP B CE3   1 
ATOM   2926 C CZ2   . TRP C 1 126 ? -41.153 -19.370 59.594 1.00 18.93 ? 143 TRP B CZ2   1 
ATOM   2927 C CZ3   . TRP C 1 126 ? -42.979 -18.092 58.673 1.00 17.72 ? 143 TRP B CZ3   1 
ATOM   2928 C CH2   . TRP C 1 126 ? -41.795 -18.826 58.522 1.00 15.46 ? 143 TRP B CH2   1 
ATOM   2929 N N     . ASP C 1 127 ? -46.648 -15.449 62.501 1.00 21.86 ? 144 ASP B N     1 
ATOM   2930 C CA    . ASP C 1 127 ? -48.017 -15.227 62.939 1.00 20.06 ? 144 ASP B CA    1 
ATOM   2931 C C     . ASP C 1 127 ? -48.633 -16.552 63.369 1.00 23.17 ? 144 ASP B C     1 
ATOM   2932 O O     . ASP C 1 127 ? -48.483 -17.571 62.693 1.00 23.70 ? 144 ASP B O     1 
ATOM   2933 C CB    . ASP C 1 127 ? -48.866 -14.666 61.797 1.00 23.02 ? 144 ASP B CB    1 
ATOM   2934 C CG    . ASP C 1 127 ? -48.522 -13.243 61.442 1.00 25.00 ? 144 ASP B CG    1 
ATOM   2935 O OD1   . ASP C 1 127 ? -47.720 -12.612 62.158 1.00 24.42 ? 144 ASP B OD1   1 
ATOM   2936 O OD2   . ASP C 1 127 ? -49.074 -12.756 60.432 1.00 31.10 ? 144 ASP B OD2   1 
ATOM   2937 N N     . TYR C 1 128 ? -49.363 -16.553 64.478 1.00 21.17 ? 145 TYR B N     1 
ATOM   2938 C CA    . TYR C 1 128 ? -49.976 -17.807 64.872 1.00 18.01 ? 145 TYR B CA    1 
ATOM   2939 C C     . TYR C 1 128 ? -51.335 -17.518 65.473 1.00 22.99 ? 145 TYR B C     1 
ATOM   2940 O O     . TYR C 1 128 ? -51.636 -16.395 65.878 1.00 20.52 ? 145 TYR B O     1 
ATOM   2941 C CB    . TYR C 1 128 ? -49.088 -18.563 65.856 1.00 17.56 ? 145 TYR B CB    1 
ATOM   2942 C CG    . TYR C 1 128 ? -49.065 -17.947 67.233 1.00 20.51 ? 145 TYR B CG    1 
ATOM   2943 C CD1   . TYR C 1 128 ? -48.220 -16.886 67.527 1.00 18.84 ? 145 TYR B CD1   1 
ATOM   2944 C CD2   . TYR C 1 128 ? -49.767 -18.537 68.275 1.00 23.47 ? 145 TYR B CD2   1 
ATOM   2945 C CE1   . TYR C 1 128 ? -48.178 -16.330 68.804 1.00 20.94 ? 145 TYR B CE1   1 
ATOM   2946 C CE2   . TYR C 1 128 ? -49.717 -18.008 69.564 1.00 20.93 ? 145 TYR B CE2   1 
ATOM   2947 C CZ    . TYR C 1 128 ? -48.914 -16.905 69.817 1.00 23.86 ? 145 TYR B CZ    1 
ATOM   2948 O OH    . TYR C 1 128 ? -48.850 -16.354 71.080 1.00 20.99 ? 145 TYR B OH    1 
ATOM   2949 N N     . GLU C 1 129 ? -52.151 -18.551 65.499 1.00 21.86 ? 146 GLU B N     1 
ATOM   2950 C CA    . GLU C 1 129 ? -53.441 -18.535 66.153 1.00 24.83 ? 146 GLU B CA    1 
ATOM   2951 C C     . GLU C 1 129 ? -53.266 -19.263 67.476 1.00 24.53 ? 146 GLU B C     1 
ATOM   2952 O O     . GLU C 1 129 ? -52.536 -20.258 67.549 1.00 24.63 ? 146 GLU B O     1 
ATOM   2953 C CB    . GLU C 1 129 ? -54.481 -19.203 65.262 1.00 27.38 ? 146 GLU B CB    1 
ATOM   2954 C CG    . GLU C 1 129 ? -54.680 -18.397 63.961 1.00 29.95 ? 146 GLU B CG    1 
ATOM   2955 C CD    . GLU C 1 129 ? -55.749 -18.952 63.027 1.00 36.33 ? 146 GLU B CD    1 
ATOM   2956 O OE1   . GLU C 1 129 ? -56.147 -20.128 63.201 1.00 42.84 ? 146 GLU B OE1   1 
ATOM   2957 O OE2   . GLU C 1 129 ? -56.180 -18.210 62.110 1.00 38.16 ? 146 GLU B OE2   1 
ATOM   2958 N N     . GLU C 1 130 ? -53.920 -18.749 68.521 1.00 29.39 ? 147 GLU B N     1 
ATOM   2959 C CA    . GLU C 1 130 ? -53.580 -19.143 69.891 1.00 27.53 ? 147 GLU B CA    1 
ATOM   2960 C C     . GLU C 1 130 ? -53.510 -20.655 70.082 1.00 29.82 ? 147 GLU B C     1 
ATOM   2961 O O     . GLU C 1 130 ? -52.650 -21.150 70.819 1.00 30.15 ? 147 GLU B O     1 
ATOM   2962 C CB    . GLU C 1 130 ? -54.581 -18.547 70.876 1.00 34.95 ? 147 GLU B CB    1 
ATOM   2963 C CG    . GLU C 1 130 ? -55.979 -19.018 70.632 1.00 34.12 ? 147 GLU B CG    1 
ATOM   2964 C CD    . GLU C 1 130 ? -56.343 -20.161 71.533 0.70 34.15 ? 147 GLU B CD    1 
ATOM   2965 O OE1   . GLU C 1 130 ? -57.230 -20.954 71.150 0.62 34.30 ? 147 GLU B OE1   1 
ATOM   2966 O OE2   . GLU C 1 130 ? -55.683 -20.305 72.586 0.79 39.20 ? 147 GLU B OE2   1 
ATOM   2967 N N     . GLY C 1 131 ? -54.395 -21.408 69.426 1.00 26.06 ? 148 GLY B N     1 
ATOM   2968 C CA    . GLY C 1 131 ? -54.358 -22.850 69.555 1.00 26.94 ? 148 GLY B CA    1 
ATOM   2969 C C     . GLY C 1 131 ? -53.166 -23.517 68.894 1.00 26.88 ? 148 GLY B C     1 
ATOM   2970 O O     . GLY C 1 131 ? -52.935 -24.704 69.133 1.00 28.27 ? 148 GLY B O     1 
ATOM   2971 N N     . GLU C 1 132 ? -52.406 -22.790 68.087 1.00 23.88 ? 149 GLU B N     1 
ATOM   2972 C CA    . GLU C 1 132 ? -51.341 -23.393 67.295 1.00 25.84 ? 149 GLU B CA    1 
ATOM   2973 C C     . GLU C 1 132 ? -49.995 -23.396 67.994 1.00 24.71 ? 149 GLU B C     1 
ATOM   2974 O O     . GLU C 1 132 ? -49.018 -23.889 67.416 1.00 22.91 ? 149 GLU B O     1 
ATOM   2975 C CB    . GLU C 1 132 ? -51.191 -22.651 65.960 1.00 23.96 ? 149 GLU B CB    1 
ATOM   2976 C CG    . GLU C 1 132 ? -52.425 -22.626 65.093 1.00 26.05 ? 149 GLU B CG    1 
ATOM   2977 C CD    . GLU C 1 132 ? -52.224 -21.720 63.897 1.00 27.50 ? 149 GLU B CD    1 
ATOM   2978 O OE1   . GLU C 1 132 ? -51.349 -20.840 63.999 1.00 24.78 ? 149 GLU B OE1   1 
ATOM   2979 O OE2   . GLU C 1 132 ? -52.903 -21.901 62.861 1.00 28.69 ? 149 GLU B OE2   1 
ATOM   2980 N N     . VAL C 1 133 ? -49.900 -22.853 69.204 1.00 22.49 ? 150 VAL B N     1 
ATOM   2981 C CA    . VAL C 1 133 ? -48.571 -22.506 69.676 1.00 23.75 ? 150 VAL B CA    1 
ATOM   2982 C C     . VAL C 1 133 ? -47.728 -23.759 69.930 1.00 24.17 ? 150 VAL B C     1 
ATOM   2983 O O     . VAL C 1 133 ? -46.525 -23.765 69.636 1.00 22.31 ? 150 VAL B O     1 
ATOM   2984 C CB    . VAL C 1 133 ? -48.658 -21.570 70.898 1.00 28.83 ? 150 VAL B CB    1 
ATOM   2985 C CG1   . VAL C 1 133 ? -48.799 -22.341 72.175 1.00 25.40 ? 150 VAL B CG1   1 
ATOM   2986 C CG2   . VAL C 1 133 ? -47.438 -20.641 70.919 1.00 26.75 ? 150 VAL B CG2   1 
ATOM   2987 N N     . GLU C 1 134 ? -48.339 -24.850 70.428 1.00 22.03 ? 151 GLU B N     1 
ATOM   2988 C CA    . GLU C 1 134 ? -47.546 -26.048 70.684 1.00 24.15 ? 151 GLU B CA    1 
ATOM   2989 C C     . GLU C 1 134 ? -47.049 -26.669 69.385 1.00 23.84 ? 151 GLU B C     1 
ATOM   2990 O O     . GLU C 1 134 ? -45.882 -27.088 69.295 1.00 20.44 ? 151 GLU B O     1 
ATOM   2991 C CB    . GLU C 1 134 ? -48.334 -27.061 71.520 1.00 22.88 ? 151 GLU B CB    1 
ATOM   2992 C CG    . GLU C 1 134 ? -48.548 -26.596 72.973 1.00 23.47 ? 151 GLU B CG    1 
ATOM   2993 C CD    . GLU C 1 134 ? -49.753 -25.685 73.179 1.00 28.46 ? 151 GLU B CD    1 
ATOM   2994 O OE1   . GLU C 1 134 ? -50.470 -25.357 72.199 1.00 28.39 ? 151 GLU B OE1   1 
ATOM   2995 O OE2   . GLU C 1 134 ? -49.944 -25.255 74.341 1.00 27.68 ? 151 GLU B OE2   1 
ATOM   2996 N N     . ALA C 1 135 ? -47.920 -26.737 68.373 1.00 20.16 ? 152 ALA B N     1 
ATOM   2997 C CA    . ALA C 1 135 ? -47.516 -27.244 67.062 1.00 23.81 ? 152 ALA B CA    1 
ATOM   2998 C C     . ALA C 1 135 ? -46.432 -26.368 66.449 1.00 22.37 ? 152 ALA B C     1 
ATOM   2999 O O     . ALA C 1 135 ? -45.491 -26.870 65.835 1.00 20.80 ? 152 ALA B O     1 
ATOM   3000 C CB    . ALA C 1 135 ? -48.729 -27.312 66.130 1.00 20.99 ? 152 ALA B CB    1 
ATOM   3001 N N     . LEU C 1 136 ? -46.556 -25.050 66.603 1.00 21.89 ? 153 LEU B N     1 
ATOM   3002 C CA    . LEU C 1 136 ? -45.530 -24.151 66.096 1.00 19.02 ? 153 LEU B CA    1 
ATOM   3003 C C     . LEU C 1 136 ? -44.187 -24.451 66.737 1.00 18.87 ? 153 LEU B C     1 
ATOM   3004 O O     . LEU C 1 136 ? -43.170 -24.581 66.050 1.00 18.54 ? 153 LEU B O     1 
ATOM   3005 C CB    . LEU C 1 136 ? -45.929 -22.707 66.374 1.00 21.35 ? 153 LEU B CB    1 
ATOM   3006 C CG    . LEU C 1 136 ? -45.152 -21.594 65.672 1.00 20.75 ? 153 LEU B CG    1 
ATOM   3007 C CD1   . LEU C 1 136 ? -46.054 -20.364 65.598 1.00 21.20 ? 153 LEU B CD1   1 
ATOM   3008 C CD2   . LEU C 1 136 ? -43.823 -21.252 66.390 1.00 19.64 ? 153 LEU B CD2   1 
ATOM   3009 N N     . LEU C 1 137 ? -44.158 -24.541 68.069 1.00 18.75 ? 154 LEU B N     1 
ATOM   3010 C CA    . LEU C 1 137 ? -42.892 -24.790 68.742 1.00 16.77 ? 154 LEU B CA    1 
ATOM   3011 C C     . LEU C 1 137 ? -42.344 -26.172 68.387 1.00 18.66 ? 154 LEU B C     1 
ATOM   3012 O O     . LEU C 1 137 ? -41.143 -26.320 68.144 1.00 18.49 ? 154 LEU B O     1 
ATOM   3013 C CB    . LEU C 1 137 ? -43.076 -24.632 70.260 1.00 18.26 ? 154 LEU B CB    1 
ATOM   3014 C CG    . LEU C 1 137 ? -43.488 -23.221 70.721 1.00 19.21 ? 154 LEU B CG    1 
ATOM   3015 C CD1   . LEU C 1 137 ? -43.824 -23.191 72.231 1.00 19.32 ? 154 LEU B CD1   1 
ATOM   3016 C CD2   . LEU C 1 137 ? -42.373 -22.217 70.429 1.00 19.99 ? 154 LEU B CD2   1 
ATOM   3017 N N     . ASP C 1 138 ? -43.203 -27.191 68.316 1.00 18.62 ? 155 ASP B N     1 
ATOM   3018 C CA    . ASP C 1 138 ? -42.735 -28.505 67.855 1.00 21.79 ? 155 ASP B CA    1 
ATOM   3019 C C     . ASP C 1 138 ? -42.049 -28.400 66.492 1.00 22.16 ? 155 ASP B C     1 
ATOM   3020 O O     . ASP C 1 138 ? -40.969 -28.964 66.281 1.00 21.11 ? 155 ASP B O     1 
ATOM   3021 C CB    . ASP C 1 138 ? -43.892 -29.496 67.743 1.00 21.63 ? 155 ASP B CB    1 
ATOM   3022 C CG    . ASP C 1 138 ? -44.392 -30.000 69.078 1.00 29.18 ? 155 ASP B CG    1 
ATOM   3023 O OD1   . ASP C 1 138 ? -43.852 -29.610 70.131 1.00 28.20 ? 155 ASP B OD1   1 
ATOM   3024 O OD2   . ASP C 1 138 ? -45.358 -30.795 69.063 1.00 33.37 ? 155 ASP B OD2   1 
ATOM   3025 N N     . ARG C 1 139 ? -42.677 -27.698 65.546 1.00 21.39 ? 156 ARG B N     1 
ATOM   3026 C CA    . ARG C 1 139 ? -42.079 -27.560 64.219 1.00 22.26 ? 156 ARG B CA    1 
ATOM   3027 C C     . ARG C 1 139 ? -40.734 -26.855 64.282 1.00 22.41 ? 156 ARG B C     1 
ATOM   3028 O O     . ARG C 1 139 ? -39.790 -27.230 63.573 1.00 20.53 ? 156 ARG B O     1 
ATOM   3029 C CB    . ARG C 1 139 ? -43.019 -26.811 63.269 1.00 17.40 ? 156 ARG B CB    1 
ATOM   3030 C CG    . ARG C 1 139 ? -44.188 -27.644 62.854 1.00 21.62 ? 156 ARG B CG    1 
ATOM   3031 C CD    . ARG C 1 139 ? -45.218 -26.899 62.018 1.00 22.64 ? 156 ARG B CD    1 
ATOM   3032 N NE    . ARG C 1 139 ? -44.637 -26.238 60.850 1.00 22.12 ? 156 ARG B NE    1 
ATOM   3033 C CZ    . ARG C 1 139 ? -44.283 -26.854 59.728 1.00 23.84 ? 156 ARG B CZ    1 
ATOM   3034 N NH1   . ARG C 1 139 ? -44.398 -28.169 59.589 1.00 20.12 ? 156 ARG B NH1   1 
ATOM   3035 N NH2   . ARG C 1 139 ? -43.830 -26.130 58.706 1.00 21.42 ? 156 ARG B NH2   1 
ATOM   3036 N N     . TYR C 1 140 ? -40.627 -25.814 65.109 1.00 20.63 ? 157 TYR B N     1 
ATOM   3037 C CA    . TYR C 1 140 ? -39.372 -25.086 65.184 1.00 19.34 ? 157 TYR B CA    1 
ATOM   3038 C C     . TYR C 1 140 ? -38.246 -25.995 65.664 1.00 23.54 ? 157 TYR B C     1 
ATOM   3039 O O     . TYR C 1 140 ? -37.171 -26.048 65.052 1.00 19.44 ? 157 TYR B O     1 
ATOM   3040 C CB    . TYR C 1 140 ? -39.515 -23.870 66.103 1.00 18.47 ? 157 TYR B CB    1 
ATOM   3041 C CG    . TYR C 1 140 ? -38.259 -23.047 66.148 1.00 20.13 ? 157 TYR B CG    1 
ATOM   3042 C CD1   . TYR C 1 140 ? -38.009 -22.066 65.189 1.00 19.36 ? 157 TYR B CD1   1 
ATOM   3043 C CD2   . TYR C 1 140 ? -37.294 -23.273 67.117 1.00 19.94 ? 157 TYR B CD2   1 
ATOM   3044 C CE1   . TYR C 1 140 ? -36.866 -21.333 65.220 1.00 19.98 ? 157 TYR B CE1   1 
ATOM   3045 C CE2   . TYR C 1 140 ? -36.144 -22.538 67.152 1.00 21.99 ? 157 TYR B CE2   1 
ATOM   3046 C CZ    . TYR C 1 140 ? -35.933 -21.571 66.197 1.00 20.87 ? 157 TYR B CZ    1 
ATOM   3047 O OH    . TYR C 1 140 ? -34.792 -20.828 66.224 1.00 24.63 ? 157 TYR B OH    1 
ATOM   3048 N N     . PHE C 1 141 ? -38.485 -26.730 66.759 1.00 21.49 ? 158 PHE B N     1 
ATOM   3049 C CA    . PHE C 1 141 ? -37.424 -27.488 67.398 1.00 21.37 ? 158 PHE B CA    1 
ATOM   3050 C C     . PHE C 1 141 ? -37.221 -28.856 66.777 1.00 29.28 ? 158 PHE B C     1 
ATOM   3051 O O     . PHE C 1 141 ? -36.161 -29.465 66.985 1.00 27.52 ? 158 PHE B O     1 
ATOM   3052 C CB    . PHE C 1 141 ? -37.717 -27.605 68.889 1.00 20.77 ? 158 PHE B CB    1 
ATOM   3053 C CG    . PHE C 1 141 ? -37.557 -26.301 69.584 1.00 21.77 ? 158 PHE B CG    1 
ATOM   3054 C CD1   . PHE C 1 141 ? -36.289 -25.774 69.784 1.00 21.83 ? 158 PHE B CD1   1 
ATOM   3055 C CD2   . PHE C 1 141 ? -38.667 -25.555 69.954 1.00 22.20 ? 158 PHE B CD2   1 
ATOM   3056 C CE1   . PHE C 1 141 ? -36.110 -24.538 70.370 1.00 24.11 ? 158 PHE B CE1   1 
ATOM   3057 C CE2   . PHE C 1 141 ? -38.498 -24.312 70.554 1.00 19.95 ? 158 PHE B CE2   1 
ATOM   3058 C CZ    . PHE C 1 141 ? -37.214 -23.806 70.761 1.00 22.28 ? 158 PHE B CZ    1 
ATOM   3059 N N     . GLU C 1 142 ? -38.202 -29.336 66.011 1.00 24.22 ? 159 GLU B N     1 
ATOM   3060 C CA    . GLU C 1 142 ? -38.024 -30.581 65.268 1.00 30.56 ? 159 GLU B CA    1 
ATOM   3061 C C     . GLU C 1 142 ? -37.023 -30.388 64.142 1.00 35.48 ? 159 GLU B C     1 
ATOM   3062 O O     . GLU C 1 142 ? -36.267 -31.307 63.804 1.00 36.88 ? 159 GLU B O     1 
ATOM   3063 C CB    . GLU C 1 142 ? -39.366 -31.049 64.704 1.00 28.13 ? 159 GLU B CB    1 
ATOM   3064 C CG    . GLU C 1 142 ? -40.075 -32.115 65.558 1.00 37.00 ? 159 GLU B CG    1 
ATOM   3065 C CD    . GLU C 1 142 ? -41.592 -31.951 65.599 0.45 28.72 ? 159 GLU B CD    1 
ATOM   3066 O OE1   . GLU C 1 142 ? -42.208 -32.293 66.630 0.64 29.46 ? 159 GLU B OE1   1 
ATOM   3067 O OE2   . GLU C 1 142 ? -42.178 -31.516 64.588 0.49 30.26 ? 159 GLU B OE2   1 
ATOM   3068 N N     . ALA C 1 143 ? -37.004 -29.196 63.552 1.00 32.71 ? 160 ALA B N     1 
ATOM   3069 C CA    . ALA C 1 143 ? -36.133 -28.903 62.426 1.00 39.57 ? 160 ALA B CA    1 
ATOM   3070 C C     . ALA C 1 143 ? -34.762 -28.410 62.867 1.00 42.35 ? 160 ALA B C     1 
ATOM   3071 O O     . ALA C 1 143 ? -33.743 -28.832 62.303 1.00 47.67 ? 160 ALA B O     1 
ATOM   3072 C CB    . ALA C 1 143 ? -36.793 -27.869 61.511 1.00 35.82 ? 160 ALA B CB    1 
ATOM   3073 N N     . ASP C 1 144 ? -34.711 -27.529 63.863 1.00 44.17 ? 161 ASP B N     1 
ATOM   3074 C CA    . ASP C 1 144 ? -33.456 -26.938 64.334 1.00 47.12 ? 161 ASP B CA    1 
ATOM   3075 C C     . ASP C 1 144 ? -33.500 -26.783 65.848 1.00 43.18 ? 161 ASP B C     1 
ATOM   3076 O O     . ASP C 1 144 ? -33.860 -25.718 66.370 1.00 38.31 ? 161 ASP B O     1 
ATOM   3077 C CB    . ASP C 1 144 ? -33.195 -25.589 63.653 1.00 48.89 ? 161 ASP B CB    1 
ATOM   3078 N N     . PRO C 1 145 ? -33.124 -27.839 66.597 1.00 45.95 ? 162 PRO B N     1 
ATOM   3079 C CA    . PRO C 1 145 ? -33.061 -27.883 68.067 1.00 44.13 ? 162 PRO B CA    1 
ATOM   3080 C C     . PRO C 1 145 ? -32.388 -26.644 68.692 1.00 47.15 ? 162 PRO B C     1 
ATOM   3081 O O     . PRO C 1 145 ? -32.650 -26.265 69.844 1.00 36.33 ? 162 PRO B O     1 
ATOM   3082 C CB    . PRO C 1 145 ? -32.221 -29.140 68.320 1.00 44.23 ? 162 PRO B CB    1 
ATOM   3083 C CG    . PRO C 1 145 ? -32.695 -30.074 67.247 1.00 44.51 ? 162 PRO B CG    1 
ATOM   3084 C CD    . PRO C 1 145 ? -32.819 -29.164 66.014 1.00 49.37 ? 162 PRO B CD    1 
HETATM 3085 P P     . 5HU D 2 .   ? -14.532 -3.560  35.698 1.00 17.05 ? 201 5HU C P     1 
HETATM 3086 O OP1   . 5HU D 2 .   ? -15.211 -4.621  36.495 1.00 17.10 ? 201 5HU C OP1   1 
HETATM 3087 O OP2   . 5HU D 2 .   ? -13.195 -3.244  36.278 1.00 17.23 ? 201 5HU C OP2   1 
HETATM 3088 O OP3   . 5HU D 2 .   ? -14.373 -3.980  34.283 1.00 18.82 ? 201 5HU C OP3   1 
HETATM 3089 O "O5'" . 5HU D 2 .   ? -15.434 -2.199  35.724 1.00 17.20 ? 201 5HU C "O5'" 1 
HETATM 3090 C "C5'" . 5HU D 2 .   ? -16.766 -2.256  35.359 1.00 19.86 ? 201 5HU C "C5'" 1 
HETATM 3091 C "C4'" . 5HU D 2 .   ? -17.289 -0.819  35.199 1.00 20.26 ? 201 5HU C "C4'" 1 
HETATM 3092 O "O4'" . 5HU D 2 .   ? -16.294 -0.031  34.277 1.00 20.39 ? 201 5HU C "O4'" 1 
HETATM 3093 C "C3'" . 5HU D 2 .   ? -18.429 -0.820  34.601 1.00 23.19 ? 201 5HU C "C3'" 1 
HETATM 3094 O "O3'" . 5HU D 2 .   ? -19.460 -0.381  35.514 1.00 21.96 ? 201 5HU C "O3'" 1 
HETATM 3095 C "C2'" . 5HU D 2 .   ? -18.349 0.271   33.404 1.00 20.12 ? 201 5HU C "C2'" 1 
HETATM 3096 C "C1'" . 5HU D 2 .   ? -17.089 0.388   33.042 1.00 19.92 ? 201 5HU C "C1'" 1 
HETATM 3097 N N1    . 5HU D 2 .   ? -16.779 -0.510  31.926 1.00 20.32 ? 201 5HU C N1    1 
HETATM 3098 C C2    . 5HU D 2 .   ? -17.501 -0.392  30.648 1.00 20.90 ? 201 5HU C C2    1 
HETATM 3099 O O2    . 5HU D 2 .   ? -18.309 0.436   30.488 1.00 21.97 ? 201 5HU C O2    1 
HETATM 3100 N N3    . 5HU D 2 .   ? -17.176 -1.305  29.538 1.00 19.58 ? 201 5HU C N3    1 
HETATM 3101 C C4    . 5HU D 2 .   ? -16.166 -2.319  29.682 1.00 21.07 ? 201 5HU C C4    1 
HETATM 3102 O O4    . 5HU D 2 .   ? -15.920 -3.042  28.797 1.00 22.88 ? 201 5HU C O4    1 
HETATM 3103 C C5    . 5HU D 2 .   ? -15.439 -2.434  30.966 1.00 19.66 ? 201 5HU C C5    1 
HETATM 3104 C C5A   . 5HU D 2 .   ? -14.369 -3.490  31.130 1.00 18.98 ? 201 5HU C C5A   1 
HETATM 3105 C C6    . 5HU D 2 .   ? -15.754 -1.516  32.081 1.00 18.27 ? 201 5HU C C6    1 
HETATM 3106 O O5B   . 5HU D 2 .   ? -13.386 -3.000  31.984 1.00 19.21 ? 201 5HU C O5B   1 
HETATM 3107 P P     . 5HU E 2 .   ? -42.592 0.558   66.298 1.00 18.08 ? 201 5HU A P     1 
HETATM 3108 O OP1   . 5HU E 2 .   ? -42.567 -0.841  66.790 1.00 19.13 ? 201 5HU A OP1   1 
HETATM 3109 O OP2   . 5HU E 2 .   ? -43.294 0.685   65.000 1.00 20.76 ? 201 5HU A OP2   1 
HETATM 3110 O OP3   . 5HU E 2 .   ? -43.293 1.403   67.309 1.00 19.49 ? 201 5HU A OP3   1 
HETATM 3111 O "O5'" . 5HU E 2 .   ? -41.075 1.093   66.085 1.00 19.63 ? 201 5HU A "O5'" 1 
HETATM 3112 C "C5'" . 5HU E 2 .   ? -40.862 2.455   65.980 1.00 22.87 ? 201 5HU A "C5'" 1 
HETATM 3113 C "C4'" . 5HU E 2 .   ? -39.384 2.660   65.608 1.00 21.32 ? 201 5HU A "C4'" 1 
HETATM 3114 O "O4'" . 5HU E 2 .   ? -39.028 1.638   64.474 1.00 22.50 ? 201 5HU A "O4'" 1 
HETATM 3115 C "C3'" . 5HU E 2 .   ? -39.204 3.838   65.121 1.00 25.04 ? 201 5HU A "C3'" 1 
HETATM 3116 O "O3'" . 5HU E 2 .   ? -38.352 4.606   66.006 1.00 25.17 ? 201 5HU A "O3'" 1 
HETATM 3117 C "C2'" . 5HU E 2 .   ? -38.431 3.665   63.697 1.00 25.38 ? 201 5HU A "C2'" 1 
HETATM 3118 C "C1'" . 5HU E 2 .   ? -38.640 2.446   63.242 1.00 22.75 ? 201 5HU A "C1'" 1 
HETATM 3119 N N1    . 5HU E 2 .   ? -39.742 2.419   62.270 1.00 21.81 ? 201 5HU A N1    1 
HETATM 3120 C C2    . 5HU E 2 .   ? -39.676 3.229   61.030 1.00 22.79 ? 201 5HU A C2    1 
HETATM 3121 O O2    . 5HU E 2 .   ? -38.753 3.906   60.769 1.00 27.42 ? 201 5HU A O2    1 
HETATM 3122 N N3    . 5HU E 2 .   ? -40.793 3.196   60.075 1.00 20.42 ? 201 5HU A N3    1 
HETATM 3123 C C4    . 5HU E 2 .   ? -41.951 2.382   60.317 1.00 23.74 ? 201 5HU A C4    1 
HETATM 3124 O O4    . 5HU E 2 .   ? -42.834 2.368   59.549 1.00 24.08 ? 201 5HU A O4    1 
HETATM 3125 C C5    . 5HU E 2 .   ? -42.026 1.564   61.548 1.00 21.37 ? 201 5HU A C5    1 
HETATM 3126 C C5A   . 5HU E 2 .   ? -43.261 0.712   61.791 1.00 22.24 ? 201 5HU A C5A   1 
HETATM 3127 C C6    . 5HU E 2 .   ? -40.900 1.592   62.515 1.00 18.63 ? 201 5HU A C6    1 
HETATM 3128 O O5B   . 5HU E 2 .   ? -42.959 -0.354  62.634 1.00 22.55 ? 201 5HU A O5B   1 
HETATM 3129 O O     . HOH F 3 .   ? -28.972 -12.820 47.173 1.00 33.25 ? 301 HOH C O     1 
HETATM 3130 O O     . HOH F 3 .   ? -11.142 -2.227  25.729 1.00 36.45 ? 302 HOH C O     1 
HETATM 3131 O O     . HOH F 3 .   ? -10.147 3.935   23.023 1.00 22.86 ? 303 HOH C O     1 
HETATM 3132 O O     . HOH F 3 .   ? -41.788 3.267   54.689 1.00 44.10 ? 304 HOH C O     1 
HETATM 3133 O O     . HOH F 3 .   ? -16.452 -3.130  26.316 1.00 37.48 ? 305 HOH C O     1 
HETATM 3134 O O     . HOH F 3 .   ? -21.900 -7.240  41.679 1.00 22.43 ? 306 HOH C O     1 
HETATM 3135 O O     . HOH F 3 .   ? -23.497 16.937  39.697 1.00 38.22 ? 307 HOH C O     1 
HETATM 3136 O O     . HOH F 3 .   ? -28.184 8.111   48.058 1.00 26.86 ? 308 HOH C O     1 
HETATM 3137 O O     . HOH F 3 .   ? -24.071 -1.779  32.618 1.00 32.59 ? 309 HOH C O     1 
HETATM 3138 O O     . HOH F 3 .   ? -13.946 -9.732  41.437 1.00 27.24 ? 310 HOH C O     1 
HETATM 3139 O O     . HOH F 3 .   ? -25.917 -13.300 36.341 1.00 39.18 ? 311 HOH C O     1 
HETATM 3140 O O     . HOH F 3 .   ? -7.053  -0.131  25.328 1.00 32.64 ? 312 HOH C O     1 
HETATM 3141 O O     . HOH F 3 .   ? -33.426 4.637   29.732 1.00 35.43 ? 313 HOH C O     1 
HETATM 3142 O O     . HOH F 3 .   ? -20.845 -11.243 43.248 1.00 31.22 ? 314 HOH C O     1 
HETATM 3143 O O     . HOH F 3 .   ? -18.104 -3.916  55.058 1.00 26.85 ? 315 HOH C O     1 
HETATM 3144 O O     . HOH F 3 .   ? -19.499 -4.628  41.110 1.00 23.92 ? 316 HOH C O     1 
HETATM 3145 O O     . HOH F 3 .   ? -17.805 -6.464  47.194 1.00 26.27 ? 317 HOH C O     1 
HETATM 3146 O O     . HOH F 3 .   ? -18.679 10.025  50.697 1.00 32.90 ? 318 HOH C O     1 
HETATM 3147 O O     . HOH F 3 .   ? -7.904  -3.658  27.327 1.00 36.20 ? 319 HOH C O     1 
HETATM 3148 O O     . HOH F 3 .   ? -27.437 16.278  35.844 1.00 35.99 ? 320 HOH C O     1 
HETATM 3149 O O     . HOH F 3 .   ? -11.852 -4.905  37.893 1.00 18.43 ? 321 HOH C O     1 
HETATM 3150 O O     . HOH F 3 .   ? -21.596 -4.038  34.622 1.00 33.44 ? 322 HOH C O     1 
HETATM 3151 O O     . HOH F 3 .   ? -14.071 13.077  39.744 1.00 23.04 ? 323 HOH C O     1 
HETATM 3152 O O     . HOH F 3 .   ? -15.395 -14.182 41.917 1.00 49.41 ? 324 HOH C O     1 
HETATM 3153 O O     . HOH F 3 .   ? -38.353 -7.215  44.716 1.00 34.67 ? 325 HOH C O     1 
HETATM 3154 O O     . HOH F 3 .   ? -13.723 1.689   22.788 1.00 28.15 ? 326 HOH C O     1 
HETATM 3155 O O     . HOH F 3 .   ? -24.637 2.062   26.420 1.00 30.90 ? 327 HOH C O     1 
HETATM 3156 O O     . HOH F 3 .   ? -42.422 -1.953  45.139 1.00 43.83 ? 328 HOH C O     1 
HETATM 3157 O O     . HOH F 3 .   ? -28.823 14.638  48.230 1.00 41.56 ? 329 HOH C O     1 
HETATM 3158 O O     . HOH F 3 .   ? -20.846 -9.322  38.226 1.00 26.50 ? 330 HOH C O     1 
HETATM 3159 O O     . HOH F 3 .   ? -40.989 -0.687  47.562 1.00 32.52 ? 331 HOH C O     1 
HETATM 3160 O O     . HOH F 3 .   ? -21.408 3.733   24.146 1.00 29.65 ? 332 HOH C O     1 
HETATM 3161 O O     . HOH F 3 .   ? -25.940 4.487   28.362 1.00 34.37 ? 333 HOH C O     1 
HETATM 3162 O O     . HOH F 3 .   ? -22.195 1.083   25.770 1.00 33.47 ? 334 HOH C O     1 
HETATM 3163 O O     . HOH F 3 .   ? -36.578 -5.570  37.218 1.00 36.29 ? 335 HOH C O     1 
HETATM 3164 O O     . HOH F 3 .   ? -7.078  2.743   25.131 1.00 27.13 ? 336 HOH C O     1 
HETATM 3165 O O     . HOH F 3 .   ? -26.089 13.852  41.752 1.00 29.31 ? 337 HOH C O     1 
HETATM 3166 O O     . HOH F 3 .   ? -10.322 11.913  33.941 1.00 30.96 ? 338 HOH C O     1 
HETATM 3167 O O     . HOH F 3 .   ? -15.532 12.151  29.818 1.00 29.29 ? 339 HOH C O     1 
HETATM 3168 O O     . HOH F 3 .   ? -21.799 1.349   33.241 1.00 26.86 ? 340 HOH C O     1 
HETATM 3169 O O     . HOH F 3 .   ? -19.763 5.211   56.797 1.00 32.74 ? 341 HOH C O     1 
HETATM 3170 O O     . HOH F 3 .   ? -34.660 1.439   49.231 1.00 34.19 ? 342 HOH C O     1 
HETATM 3171 O O     . HOH F 3 .   ? -32.060 -4.138  31.418 1.00 36.48 ? 343 HOH C O     1 
HETATM 3172 O O     . HOH F 3 .   ? -32.693 -5.141  52.829 1.00 26.52 ? 344 HOH C O     1 
HETATM 3173 O O     . HOH F 3 .   ? -23.324 20.176  47.758 1.00 52.34 ? 345 HOH C O     1 
HETATM 3174 O O     . HOH F 3 .   ? -33.478 -2.450  29.906 1.00 43.21 ? 346 HOH C O     1 
HETATM 3175 O O     . HOH F 3 .   ? -36.094 5.363   30.509 1.00 39.70 ? 347 HOH C O     1 
HETATM 3176 O O     . HOH F 3 .   ? -19.881 -6.282  54.385 1.00 25.17 ? 348 HOH C O     1 
HETATM 3177 O O     . HOH F 3 .   ? -27.273 -12.649 38.436 1.00 36.12 ? 349 HOH C O     1 
HETATM 3178 O O     . HOH F 3 .   ? -15.499 -5.683  48.564 1.00 20.06 ? 350 HOH C O     1 
HETATM 3179 O O     . HOH F 3 .   ? -14.687 -10.696 33.005 1.00 35.72 ? 351 HOH C O     1 
HETATM 3180 O O     . HOH F 3 .   ? -14.489 -10.204 51.564 1.00 37.19 ? 352 HOH C O     1 
HETATM 3181 O O     . HOH F 3 .   ? -11.381 10.145  29.448 1.00 31.94 ? 353 HOH C O     1 
HETATM 3182 O O     . HOH F 3 .   ? -21.319 -20.685 54.669 1.00 59.13 ? 354 HOH C O     1 
HETATM 3183 O O     . HOH F 3 .   ? -14.670 -5.695  28.322 1.00 35.37 ? 355 HOH C O     1 
HETATM 3184 O O     . HOH F 3 .   ? -26.024 -6.958  32.537 1.00 35.73 ? 356 HOH C O     1 
HETATM 3185 O O     . HOH F 3 .   ? -31.521 -11.834 38.729 1.00 44.32 ? 357 HOH C O     1 
HETATM 3186 O O     . HOH F 3 .   ? -21.803 -1.649  34.147 1.00 27.52 ? 358 HOH C O     1 
HETATM 3187 O O     . HOH F 3 .   ? -30.784 10.993  48.497 1.00 45.59 ? 359 HOH C O     1 
HETATM 3188 O O     . HOH F 3 .   ? -16.752 -13.586 34.757 1.00 38.53 ? 360 HOH C O     1 
HETATM 3189 O O     . HOH F 3 .   ? -25.877 4.259   54.066 1.00 30.73 ? 361 HOH C O     1 
HETATM 3190 O O     . HOH F 3 .   ? -8.834  10.460  27.623 1.00 37.60 ? 362 HOH C O     1 
HETATM 3191 O O     . HOH F 3 .   ? -31.458 12.432  30.127 1.00 37.48 ? 363 HOH C O     1 
HETATM 3192 O O     . HOH F 3 .   ? -12.750 15.395  38.637 1.00 33.38 ? 364 HOH C O     1 
HETATM 3193 O O     . HOH F 3 .   ? -18.905 -19.574 51.492 1.00 56.29 ? 365 HOH C O     1 
HETATM 3194 O O     . HOH F 3 .   ? -37.257 -9.828  37.474 1.00 48.40 ? 366 HOH C O     1 
HETATM 3195 O O     . HOH F 3 .   ? -23.314 18.024  49.699 1.00 50.11 ? 367 HOH C O     1 
HETATM 3196 O O     . HOH F 3 .   ? -31.887 9.247   53.327 1.00 44.23 ? 368 HOH C O     1 
HETATM 3197 O O     . HOH F 3 .   ? -12.256 -8.614  28.852 1.00 36.50 ? 369 HOH C O     1 
HETATM 3198 O O     . HOH F 3 .   ? -43.073 -5.846  38.980 1.00 53.55 ? 370 HOH C O     1 
HETATM 3199 O O     . HOH F 3 .   ? -28.377 3.804   53.603 1.00 30.63 ? 371 HOH C O     1 
HETATM 3200 O O     . HOH F 3 .   ? -42.791 10.029  45.613 1.00 46.98 ? 372 HOH C O     1 
HETATM 3201 O O     . HOH F 3 .   ? -33.171 12.314  47.746 1.00 51.72 ? 373 HOH C O     1 
HETATM 3202 O O     . HOH F 3 .   ? -32.927 14.556  45.949 1.00 42.74 ? 374 HOH C O     1 
HETATM 3203 O O     . HOH F 3 .   ? -9.777  12.267  22.604 1.00 36.10 ? 375 HOH C O     1 
HETATM 3204 O O     . HOH F 3 .   ? -28.173 16.884  49.480 1.00 44.64 ? 376 HOH C O     1 
HETATM 3205 O O     . HOH F 3 .   ? -17.952 -16.087 36.666 1.00 49.18 ? 377 HOH C O     1 
HETATM 3206 O O     . HOH F 3 .   ? -11.968 2.984   21.365 1.00 25.57 ? 378 HOH C O     1 
HETATM 3207 O O     . HOH F 3 .   ? -21.432 -8.372  54.947 1.00 30.78 ? 379 HOH C O     1 
HETATM 3208 O O     . HOH F 3 .   ? -36.639 19.833  28.012 1.00 44.42 ? 380 HOH C O     1 
HETATM 3209 O O     . HOH F 3 .   ? -41.162 -0.859  50.653 1.00 44.96 ? 381 HOH C O     1 
HETATM 3210 O O     . HOH F 3 .   ? -10.561 1.819   19.264 1.00 28.71 ? 382 HOH C O     1 
HETATM 3211 O O     . HOH F 3 .   ? -26.294 -4.376  32.454 1.00 39.23 ? 383 HOH C O     1 
HETATM 3212 O O     . HOH F 3 .   ? -34.002 10.585  39.694 1.00 45.18 ? 384 HOH C O     1 
HETATM 3213 O O     . HOH F 3 .   ? -14.420 -1.028  22.117 1.00 34.46 ? 385 HOH C O     1 
HETATM 3214 O O     . HOH G 3 .   ? -39.687 20.113  63.131 1.00 53.07 ? 301 HOH A O     1 
HETATM 3215 O O     . HOH G 3 .   ? -47.697 0.800   72.878 1.00 26.71 ? 302 HOH A O     1 
HETATM 3216 O O     . HOH G 3 .   ? -43.231 7.856   73.553 1.00 23.82 ? 303 HOH A O     1 
HETATM 3217 O O     . HOH G 3 .   ? -17.412 13.239  62.204 1.00 43.10 ? 304 HOH A O     1 
HETATM 3218 O O     . HOH G 3 .   ? -45.099 1.417   59.014 1.00 39.24 ? 305 HOH A O     1 
HETATM 3219 O O     . HOH G 3 .   ? -46.006 -5.392  57.824 1.00 37.19 ? 306 HOH A O     1 
HETATM 3220 O O     . HOH G 3 .   ? -40.171 4.363   57.895 1.00 33.61 ? 307 HOH A O     1 
HETATM 3221 O O     . HOH G 3 .   ? -37.761 23.395  68.130 1.00 32.71 ? 308 HOH A O     1 
HETATM 3222 O O     . HOH G 3 .   ? -25.792 9.306   76.703 1.00 28.80 ? 309 HOH A O     1 
HETATM 3223 O O     . HOH G 3 .   ? -43.306 13.295  83.348 1.00 29.94 ? 310 HOH A O     1 
HETATM 3224 O O     . HOH G 3 .   ? -49.764 2.950   65.299 1.00 34.72 ? 311 HOH A O     1 
HETATM 3225 O O     . HOH G 3 .   ? -23.088 0.099   56.337 1.00 37.82 ? 312 HOH A O     1 
HETATM 3226 O O     . HOH G 3 .   ? -38.084 1.605   85.786 1.00 32.05 ? 313 HOH A O     1 
HETATM 3227 O O     . HOH G 3 .   ? -41.599 5.077   72.144 1.00 20.50 ? 314 HOH A O     1 
HETATM 3228 O O     . HOH G 3 .   ? -19.735 10.418  67.453 1.00 31.62 ? 315 HOH A O     1 
HETATM 3229 O O     . HOH G 3 .   ? -48.052 13.077  74.717 1.00 33.52 ? 316 HOH A O     1 
HETATM 3230 O O     . HOH G 3 .   ? -25.572 -3.425  58.960 1.00 40.56 ? 317 HOH A O     1 
HETATM 3231 O O     . HOH G 3 .   ? -31.425 -5.346  57.154 1.00 25.88 ? 318 HOH A O     1 
HETATM 3232 O O     . HOH G 3 .   ? -44.104 -2.100  68.625 1.00 20.13 ? 319 HOH A O     1 
HETATM 3233 O O     . HOH G 3 .   ? -44.122 -2.052  55.014 1.00 39.84 ? 320 HOH A O     1 
HETATM 3234 O O     . HOH G 3 .   ? -37.931 -6.578  50.699 1.00 33.11 ? 321 HOH A O     1 
HETATM 3235 O O     . HOH G 3 .   ? -40.400 18.128  63.977 1.00 33.54 ? 322 HOH A O     1 
HETATM 3236 O O     . HOH G 3 .   ? -41.491 0.297   79.697 1.00 30.75 ? 323 HOH A O     1 
HETATM 3237 O O     . HOH G 3 .   ? -47.159 7.653   75.874 1.00 27.99 ? 324 HOH A O     1 
HETATM 3238 O O     . HOH G 3 .   ? -34.159 23.727  66.141 1.00 33.16 ? 325 HOH A O     1 
HETATM 3239 O O     . HOH G 3 .   ? -42.403 2.978   78.837 1.00 23.77 ? 326 HOH A O     1 
HETATM 3240 O O     . HOH G 3 .   ? -50.191 4.282   86.777 1.00 33.66 ? 327 HOH A O     1 
HETATM 3241 O O     . HOH G 3 .   ? -26.364 -4.047  66.510 1.00 27.24 ? 328 HOH A O     1 
HETATM 3242 O O     . HOH G 3 .   ? -48.159 6.967   78.175 1.00 31.64 ? 329 HOH A O     1 
HETATM 3243 O O     . HOH G 3 .   ? -39.113 21.999  69.919 1.00 23.23 ? 330 HOH A O     1 
HETATM 3244 O O     . HOH G 3 .   ? -40.032 3.978   85.647 1.00 28.01 ? 331 HOH A O     1 
HETATM 3245 O O     . HOH G 3 .   ? -49.269 13.717  70.268 1.00 34.55 ? 332 HOH A O     1 
HETATM 3246 O O     . HOH G 3 .   ? -21.825 7.109   69.203 1.00 31.79 ? 333 HOH A O     1 
HETATM 3247 O O     . HOH G 3 .   ? -33.287 -5.841  55.284 1.00 30.94 ? 334 HOH A O     1 
HETATM 3248 O O     . HOH G 3 .   ? -46.369 7.488   70.679 1.00 26.73 ? 335 HOH A O     1 
HETATM 3249 O O     . HOH G 3 .   ? -50.973 2.175   71.698 1.00 33.81 ? 336 HOH A O     1 
HETATM 3250 O O     . HOH G 3 .   ? -45.504 20.605  77.141 1.00 34.57 ? 337 HOH A O     1 
HETATM 3251 O O     . HOH G 3 .   ? -30.351 20.150  61.147 1.00 37.41 ? 338 HOH A O     1 
HETATM 3252 O O     . HOH G 3 .   ? -46.175 0.460   83.189 1.00 29.96 ? 339 HOH A O     1 
HETATM 3253 O O     . HOH G 3 .   ? -51.984 5.272   67.581 1.00 39.13 ? 340 HOH A O     1 
HETATM 3254 O O     . HOH G 3 .   ? -39.419 -5.380  80.605 1.00 40.31 ? 341 HOH A O     1 
HETATM 3255 O O     . HOH G 3 .   ? -39.016 -4.960  83.113 1.00 47.33 ? 342 HOH A O     1 
HETATM 3256 O O     . HOH G 3 .   ? -38.251 23.272  77.327 1.00 29.24 ? 343 HOH A O     1 
HETATM 3257 O O     . HOH G 3 .   ? -50.858 6.095   75.643 1.00 41.25 ? 344 HOH A O     1 
HETATM 3258 O O     . HOH G 3 .   ? -46.488 0.309   80.238 1.00 36.23 ? 345 HOH A O     1 
HETATM 3259 O O     . HOH G 3 .   ? -24.772 -5.968  64.642 1.00 40.41 ? 346 HOH A O     1 
HETATM 3260 O O     . HOH G 3 .   ? -47.426 11.836  80.041 1.00 46.51 ? 347 HOH A O     1 
HETATM 3261 O O     . HOH G 3 .   ? -21.110 11.225  69.883 1.00 34.28 ? 348 HOH A O     1 
HETATM 3262 O O     . HOH G 3 .   ? -39.278 22.272  62.919 1.00 48.88 ? 349 HOH A O     1 
HETATM 3263 O O     . HOH G 3 .   ? -29.997 -7.841  61.086 1.00 32.47 ? 350 HOH A O     1 
HETATM 3264 O O     . HOH G 3 .   ? -45.368 14.884  81.035 1.00 29.10 ? 351 HOH A O     1 
HETATM 3265 O O     . HOH G 3 .   ? -31.942 17.990  60.350 1.00 37.99 ? 352 HOH A O     1 
HETATM 3266 O O     . HOH G 3 .   ? -44.149 23.544  81.248 1.00 50.06 ? 353 HOH A O     1 
HETATM 3267 O O     . HOH G 3 .   ? -18.402 -3.799  74.143 1.00 62.80 ? 354 HOH A O     1 
HETATM 3268 O O     . HOH G 3 .   ? -55.218 7.160   71.475 1.00 58.29 ? 355 HOH A O     1 
HETATM 3269 O O     . HOH G 3 .   ? -30.129 -7.339  58.621 1.00 26.34 ? 356 HOH A O     1 
HETATM 3270 O O     . HOH G 3 .   ? -47.565 -1.858  78.178 1.00 49.02 ? 357 HOH A O     1 
HETATM 3271 O O     . HOH G 3 .   ? -23.094 15.147  71.934 1.00 49.60 ? 358 HOH A O     1 
HETATM 3272 O O     . HOH G 3 .   ? -54.649 8.175   74.050 1.00 55.41 ? 359 HOH A O     1 
HETATM 3273 O O     . HOH H 3 .   ? -43.584 -32.705 70.744 1.00 35.23 ? 201 HOH B O     1 
HETATM 3274 O O     . HOH H 3 .   ? -46.924 -31.023 67.172 1.00 37.49 ? 202 HOH B O     1 
HETATM 3275 O O     . HOH H 3 .   ? -29.685 -25.468 70.213 1.00 37.12 ? 203 HOH B O     1 
HETATM 3276 O O     . HOH H 3 .   ? -34.549 -18.979 64.553 1.00 22.55 ? 204 HOH B O     1 
HETATM 3277 O O     . HOH H 3 .   ? -52.995 -7.782  62.725 1.00 34.40 ? 205 HOH B O     1 
HETATM 3278 O O     . HOH H 3 .   ? -55.464 -22.574 63.699 1.00 35.85 ? 206 HOH B O     1 
HETATM 3279 O O     . HOH H 3 .   ? -36.156 -33.902 63.845 1.00 35.20 ? 207 HOH B O     1 
HETATM 3280 O O     . HOH H 3 .   ? -55.255 -14.040 69.856 1.00 42.50 ? 208 HOH B O     1 
HETATM 3281 O O     . HOH H 3 .   ? -46.789 -10.292 73.834 1.00 27.79 ? 209 HOH B O     1 
HETATM 3282 O O     . HOH H 3 .   ? -43.973 -8.575  73.846 1.00 31.12 ? 210 HOH B O     1 
HETATM 3283 O O     . HOH H 3 .   ? -26.963 -33.276 74.574 1.00 39.19 ? 211 HOH B O     1 
HETATM 3284 O O     . HOH H 3 .   ? -48.143 -2.923  67.101 1.00 27.01 ? 212 HOH B O     1 
HETATM 3285 O O     . HOH H 3 .   ? -40.458 -28.659 61.390 1.00 32.75 ? 213 HOH B O     1 
HETATM 3286 O O     . HOH H 3 .   ? -35.629 -31.804 68.210 1.00 27.06 ? 214 HOH B O     1 
HETATM 3287 O O     . HOH H 3 .   ? -47.720 -2.757  75.614 1.00 38.84 ? 215 HOH B O     1 
HETATM 3288 O O     . HOH H 3 .   ? -47.987 -25.999 76.299 1.00 25.94 ? 216 HOH B O     1 
HETATM 3289 O O     . HOH H 3 .   ? -45.749 -6.499  60.454 1.00 26.79 ? 217 HOH B O     1 
HETATM 3290 O O     . HOH H 3 .   ? -33.986 -28.250 71.149 1.00 28.52 ? 218 HOH B O     1 
HETATM 3291 O O     . HOH H 3 .   ? -46.531 -5.967  68.795 1.00 24.58 ? 219 HOH B O     1 
HETATM 3292 O O     . HOH H 3 .   ? -39.978 -23.138 62.355 1.00 28.80 ? 220 HOH B O     1 
HETATM 3293 O O     . HOH H 3 .   ? -43.070 -13.101 59.174 1.00 29.57 ? 221 HOH B O     1 
HETATM 3294 O O     . HOH H 3 .   ? -53.988 -19.666 75.911 1.00 35.17 ? 222 HOH B O     1 
HETATM 3295 O O     . HOH H 3 .   ? -36.028 -22.329 58.398 1.00 29.00 ? 223 HOH B O     1 
HETATM 3296 O O     . HOH H 3 .   ? -25.907 -7.491  71.738 1.00 31.97 ? 224 HOH B O     1 
HETATM 3297 O O     . HOH H 3 .   ? -57.620 -20.453 60.807 1.00 44.74 ? 225 HOH B O     1 
HETATM 3298 O O     . HOH H 3 .   ? -58.722 -14.094 68.522 1.00 35.79 ? 226 HOH B O     1 
HETATM 3299 O O     . HOH H 3 .   ? -42.413 -23.139 63.715 1.00 24.17 ? 227 HOH B O     1 
HETATM 3300 O O     . HOH H 3 .   ? -45.757 -30.260 61.021 1.00 32.74 ? 228 HOH B O     1 
HETATM 3301 O O     . HOH H 3 .   ? -45.721 -14.755 59.866 1.00 25.53 ? 229 HOH B O     1 
HETATM 3302 O O     . HOH H 3 .   ? -58.701 -7.826  66.200 1.00 45.99 ? 230 HOH B O     1 
HETATM 3303 O O     . HOH H 3 .   ? -36.008 -25.955 81.997 1.00 31.89 ? 231 HOH B O     1 
HETATM 3304 O O     . HOH H 3 .   ? -50.892 -26.729 68.600 1.00 30.41 ? 232 HOH B O     1 
HETATM 3305 O O     . HOH H 3 .   ? -48.536 -7.570  61.461 1.00 22.49 ? 233 HOH B O     1 
HETATM 3306 O O     . HOH H 3 .   ? -45.665 -4.000  67.309 1.00 19.80 ? 234 HOH B O     1 
HETATM 3307 O O     . HOH H 3 .   ? -56.640 -20.759 67.593 1.00 35.07 ? 235 HOH B O     1 
HETATM 3308 O O     . HOH H 3 .   ? -53.930 -14.493 65.913 1.00 26.65 ? 236 HOH B O     1 
HETATM 3309 O O     . HOH H 3 .   ? -39.971 -16.087 59.610 1.00 21.20 ? 237 HOH B O     1 
HETATM 3310 O O     . HOH H 3 .   ? -42.412 -1.589  77.558 1.00 20.92 ? 238 HOH B O     1 
HETATM 3311 O O     . HOH H 3 .   ? -57.902 -20.989 65.551 1.00 37.87 ? 239 HOH B O     1 
HETATM 3312 O O     . HOH H 3 .   ? -24.012 -17.341 68.274 1.00 46.20 ? 240 HOH B O     1 
HETATM 3313 O O     . HOH H 3 .   ? -24.786 -21.450 70.512 1.00 56.13 ? 241 HOH B O     1 
HETATM 3314 O O     . HOH H 3 .   ? -30.800 -13.704 64.257 1.00 34.61 ? 242 HOH B O     1 
HETATM 3315 O O     . HOH H 3 .   ? -41.583 -33.478 69.409 1.00 36.56 ? 243 HOH B O     1 
HETATM 3316 O O     . HOH H 3 .   ? -45.694 -23.232 82.782 1.00 28.62 ? 244 HOH B O     1 
HETATM 3317 O O     . HOH H 3 .   ? -27.240 -1.960  93.064 1.00 52.53 ? 245 HOH B O     1 
HETATM 3318 O O     . HOH H 3 .   ? -55.100 -15.852 68.221 1.00 30.79 ? 246 HOH B O     1 
HETATM 3319 O O     . HOH H 3 .   ? -46.132 -29.835 64.991 1.00 33.75 ? 247 HOH B O     1 
HETATM 3320 O O     . HOH H 3 .   ? -24.446 -19.684 72.635 1.00 48.18 ? 248 HOH B O     1 
HETATM 3321 O O     . HOH H 3 .   ? -40.104 -6.886  78.837 1.00 39.08 ? 249 HOH B O     1 
HETATM 3322 O O     . HOH H 3 .   ? -22.632 -18.206 73.728 1.00 54.71 ? 250 HOH B O     1 
HETATM 3323 O O     . HOH H 3 .   ? -48.999 -0.693  74.545 1.00 36.41 ? 251 HOH B O     1 
HETATM 3324 O O     . HOH H 3 .   ? -50.840 -8.516  61.044 1.00 38.32 ? 252 HOH B O     1 
HETATM 3325 O O     . HOH H 3 .   ? -49.505 -26.721 78.495 1.00 38.17 ? 253 HOH B O     1 
HETATM 3326 O O     . HOH H 3 .   ? -23.134 -7.446  71.178 1.00 42.07 ? 254 HOH B O     1 
# 
