data_8RPF
# 
_entry.id   8RPF 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.398 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8RPF         pdb_00008rpf 10.2210/pdb8rpf/pdb 
WWPDB D_1292135690 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-11-13 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8RPF 
_pdbx_database_status.recvd_initial_deposition_date   2024-01-15 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
2 mmartine@unizar.es   Marta    Martinez-Julvez ? 'principal investigator/group leader' 0000-0001-9047-0046 
3 ferreira@unizar.es   Patricia Ferreira        ? 'principal investigator/group leader' 0000-0003-4076-6118 
4 mangasjuan@uniovi.es Juan     Mangas-Sanchez  ? 'principal investigator/group leader' 0000-0002-3364-1512 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Martinez-Julvez, M.' 1 0000-0001-9047-0046 
'Ferreira, P.'        2 0000-0003-4076-6118 
'Cinca, P.'           3 0000-0003-4929-9595 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   GW 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Appl.Microbiol.Biotechnol. 
_citation.journal_id_ASTM           AMBIDG 
_citation.journal_id_CSD            0786 
_citation.journal_id_ISSN           1432-0614 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            108 
_citation.language                  ? 
_citation.page_first                498 
_citation.page_last                 498 
_citation.title                     
'Discovery, characterization, and synthetic potential of two novel bacterial aryl-alcohol oxidases.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1007/s00253-024-13314-z 
_citation.pdbx_database_id_PubMed   39470785 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Cinca-Fernando, P.'  1 ?                   
primary 'Ascaso-Alegre, C.'   2 ?                   
primary 'Sevilla, E.'         3 ?                   
primary 'Martinez-Julvez, M.' 4 ?                   
primary 'Mangas-Sanchez, J.'  5 ?                   
primary 'Ferreira, P.'        6 0000-0003-4076-6118 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'alcohol oxidase'             60949.062 2   1.1.3.7 ? ? ? 
2 non-polymer syn 1-BUTANOL                     74.122    2   ?       ? ? ? 
3 non-polymer syn 'FLAVIN-ADENINE DINUCLEOTIDE' 785.550   2   ?       ? ? ? 
4 non-polymer syn HEXANE-1,6-DIOL               118.174   2   ?       ? ? ? 
5 water       nat water                         18.015    740 ?       ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MGSSHHHHHHSSGLVPRGSHMKKFDFIIVGAGTAGPVIASRLTEKEHINVLLLEAGGENTNELSRIPGAFFKVLGTDYDW
TYSSVEQTGLNNRSIYSPSGKVVGGSSAINVGVWVRGTKEDYDSWEAQGAKGWNFSKALEMFQKIEQTNLGPSKYHGDKG
KVKLTDSSYPTPFVHTLLNGFKEAGFGEIGDYAGENPYSIDIMQKIYENNTRRTPADSYLTEDVRARENLTIITHAFVRK
VLFEGTKAIGVEVEIDGQIQNMYASKEIILSAGTFNTPKLLKLSGVGPREELEKFGIPVIANVPGVGENLNDHLMFTLKF
VSEKNIEDSIFNPLSDEAIDQWYKNKTGPSSYYPGVASGFVSSDGTKTGADFELIFTYTHGADGTEKEFANIEDIQAQSG
YSVTVILLQPKSRGQLLLASTNPYDAPLINPRYFSDSSDMERFIKGVRYTQKITKTESLEPYTYLAHPALDATDEIIESL
IRNEASTVFHPVGTARMGDVENDSLAVVDSSLKVRGIQGLRVADASIIPAVNRGHTMAPVVYVGEMASEIIINDN
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MGSSHHHHHHSSGLVPRGSHMKKFDFIIVGAGTAGPVIASRLTEKEHINVLLLEAGGENTNELSRIPGAFFKVLGTDYDW
TYSSVEQTGLNNRSIYSPSGKVVGGSSAINVGVWVRGTKEDYDSWEAQGAKGWNFSKALEMFQKIEQTNLGPSKYHGDKG
KVKLTDSSYPTPFVHTLLNGFKEAGFGEIGDYAGENPYSIDIMQKIYENNTRRTPADSYLTEDVRARENLTIITHAFVRK
VLFEGTKAIGVEVEIDGQIQNMYASKEIILSAGTFNTPKLLKLSGVGPREELEKFGIPVIANVPGVGENLNDHLMFTLKF
VSEKNIEDSIFNPLSDEAIDQWYKNKTGPSSYYPGVASGFVSSDGTKTGADFELIFTYTHGADGTEKEFANIEDIQAQSG
YSVTVILLQPKSRGQLLLASTNPYDAPLINPRYFSDSSDMERFIKGVRYTQKITKTESLEPYTYLAHPALDATDEIIESL
IRNEASTVFHPVGTARMGDVENDSLAVVDSSLKVRGIQGLRVADASIIPAVNRGHTMAPVVYVGEMASEIIINDN
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 1-BUTANOL                     1BO 
3 'FLAVIN-ADENINE DINUCLEOTIDE' FAD 
4 HEXANE-1,6-DIOL               HEZ 
5 water                         HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLY n 
1 3   SER n 
1 4   SER n 
1 5   HIS n 
1 6   HIS n 
1 7   HIS n 
1 8   HIS n 
1 9   HIS n 
1 10  HIS n 
1 11  SER n 
1 12  SER n 
1 13  GLY n 
1 14  LEU n 
1 15  VAL n 
1 16  PRO n 
1 17  ARG n 
1 18  GLY n 
1 19  SER n 
1 20  HIS n 
1 21  MET n 
1 22  LYS n 
1 23  LYS n 
1 24  PHE n 
1 25  ASP n 
1 26  PHE n 
1 27  ILE n 
1 28  ILE n 
1 29  VAL n 
1 30  GLY n 
1 31  ALA n 
1 32  GLY n 
1 33  THR n 
1 34  ALA n 
1 35  GLY n 
1 36  PRO n 
1 37  VAL n 
1 38  ILE n 
1 39  ALA n 
1 40  SER n 
1 41  ARG n 
1 42  LEU n 
1 43  THR n 
1 44  GLU n 
1 45  LYS n 
1 46  GLU n 
1 47  HIS n 
1 48  ILE n 
1 49  ASN n 
1 50  VAL n 
1 51  LEU n 
1 52  LEU n 
1 53  LEU n 
1 54  GLU n 
1 55  ALA n 
1 56  GLY n 
1 57  GLY n 
1 58  GLU n 
1 59  ASN n 
1 60  THR n 
1 61  ASN n 
1 62  GLU n 
1 63  LEU n 
1 64  SER n 
1 65  ARG n 
1 66  ILE n 
1 67  PRO n 
1 68  GLY n 
1 69  ALA n 
1 70  PHE n 
1 71  PHE n 
1 72  LYS n 
1 73  VAL n 
1 74  LEU n 
1 75  GLY n 
1 76  THR n 
1 77  ASP n 
1 78  TYR n 
1 79  ASP n 
1 80  TRP n 
1 81  THR n 
1 82  TYR n 
1 83  SER n 
1 84  SER n 
1 85  VAL n 
1 86  GLU n 
1 87  GLN n 
1 88  THR n 
1 89  GLY n 
1 90  LEU n 
1 91  ASN n 
1 92  ASN n 
1 93  ARG n 
1 94  SER n 
1 95  ILE n 
1 96  TYR n 
1 97  SER n 
1 98  PRO n 
1 99  SER n 
1 100 GLY n 
1 101 LYS n 
1 102 VAL n 
1 103 VAL n 
1 104 GLY n 
1 105 GLY n 
1 106 SER n 
1 107 SER n 
1 108 ALA n 
1 109 ILE n 
1 110 ASN n 
1 111 VAL n 
1 112 GLY n 
1 113 VAL n 
1 114 TRP n 
1 115 VAL n 
1 116 ARG n 
1 117 GLY n 
1 118 THR n 
1 119 LYS n 
1 120 GLU n 
1 121 ASP n 
1 122 TYR n 
1 123 ASP n 
1 124 SER n 
1 125 TRP n 
1 126 GLU n 
1 127 ALA n 
1 128 GLN n 
1 129 GLY n 
1 130 ALA n 
1 131 LYS n 
1 132 GLY n 
1 133 TRP n 
1 134 ASN n 
1 135 PHE n 
1 136 SER n 
1 137 LYS n 
1 138 ALA n 
1 139 LEU n 
1 140 GLU n 
1 141 MET n 
1 142 PHE n 
1 143 GLN n 
1 144 LYS n 
1 145 ILE n 
1 146 GLU n 
1 147 GLN n 
1 148 THR n 
1 149 ASN n 
1 150 LEU n 
1 151 GLY n 
1 152 PRO n 
1 153 SER n 
1 154 LYS n 
1 155 TYR n 
1 156 HIS n 
1 157 GLY n 
1 158 ASP n 
1 159 LYS n 
1 160 GLY n 
1 161 LYS n 
1 162 VAL n 
1 163 LYS n 
1 164 LEU n 
1 165 THR n 
1 166 ASP n 
1 167 SER n 
1 168 SER n 
1 169 TYR n 
1 170 PRO n 
1 171 THR n 
1 172 PRO n 
1 173 PHE n 
1 174 VAL n 
1 175 HIS n 
1 176 THR n 
1 177 LEU n 
1 178 LEU n 
1 179 ASN n 
1 180 GLY n 
1 181 PHE n 
1 182 LYS n 
1 183 GLU n 
1 184 ALA n 
1 185 GLY n 
1 186 PHE n 
1 187 GLY n 
1 188 GLU n 
1 189 ILE n 
1 190 GLY n 
1 191 ASP n 
1 192 TYR n 
1 193 ALA n 
1 194 GLY n 
1 195 GLU n 
1 196 ASN n 
1 197 PRO n 
1 198 TYR n 
1 199 SER n 
1 200 ILE n 
1 201 ASP n 
1 202 ILE n 
1 203 MET n 
1 204 GLN n 
1 205 LYS n 
1 206 ILE n 
1 207 TYR n 
1 208 GLU n 
1 209 ASN n 
1 210 ASN n 
1 211 THR n 
1 212 ARG n 
1 213 ARG n 
1 214 THR n 
1 215 PRO n 
1 216 ALA n 
1 217 ASP n 
1 218 SER n 
1 219 TYR n 
1 220 LEU n 
1 221 THR n 
1 222 GLU n 
1 223 ASP n 
1 224 VAL n 
1 225 ARG n 
1 226 ALA n 
1 227 ARG n 
1 228 GLU n 
1 229 ASN n 
1 230 LEU n 
1 231 THR n 
1 232 ILE n 
1 233 ILE n 
1 234 THR n 
1 235 HIS n 
1 236 ALA n 
1 237 PHE n 
1 238 VAL n 
1 239 ARG n 
1 240 LYS n 
1 241 VAL n 
1 242 LEU n 
1 243 PHE n 
1 244 GLU n 
1 245 GLY n 
1 246 THR n 
1 247 LYS n 
1 248 ALA n 
1 249 ILE n 
1 250 GLY n 
1 251 VAL n 
1 252 GLU n 
1 253 VAL n 
1 254 GLU n 
1 255 ILE n 
1 256 ASP n 
1 257 GLY n 
1 258 GLN n 
1 259 ILE n 
1 260 GLN n 
1 261 ASN n 
1 262 MET n 
1 263 TYR n 
1 264 ALA n 
1 265 SER n 
1 266 LYS n 
1 267 GLU n 
1 268 ILE n 
1 269 ILE n 
1 270 LEU n 
1 271 SER n 
1 272 ALA n 
1 273 GLY n 
1 274 THR n 
1 275 PHE n 
1 276 ASN n 
1 277 THR n 
1 278 PRO n 
1 279 LYS n 
1 280 LEU n 
1 281 LEU n 
1 282 LYS n 
1 283 LEU n 
1 284 SER n 
1 285 GLY n 
1 286 VAL n 
1 287 GLY n 
1 288 PRO n 
1 289 ARG n 
1 290 GLU n 
1 291 GLU n 
1 292 LEU n 
1 293 GLU n 
1 294 LYS n 
1 295 PHE n 
1 296 GLY n 
1 297 ILE n 
1 298 PRO n 
1 299 VAL n 
1 300 ILE n 
1 301 ALA n 
1 302 ASN n 
1 303 VAL n 
1 304 PRO n 
1 305 GLY n 
1 306 VAL n 
1 307 GLY n 
1 308 GLU n 
1 309 ASN n 
1 310 LEU n 
1 311 ASN n 
1 312 ASP n 
1 313 HIS n 
1 314 LEU n 
1 315 MET n 
1 316 PHE n 
1 317 THR n 
1 318 LEU n 
1 319 LYS n 
1 320 PHE n 
1 321 VAL n 
1 322 SER n 
1 323 GLU n 
1 324 LYS n 
1 325 ASN n 
1 326 ILE n 
1 327 GLU n 
1 328 ASP n 
1 329 SER n 
1 330 ILE n 
1 331 PHE n 
1 332 ASN n 
1 333 PRO n 
1 334 LEU n 
1 335 SER n 
1 336 ASP n 
1 337 GLU n 
1 338 ALA n 
1 339 ILE n 
1 340 ASP n 
1 341 GLN n 
1 342 TRP n 
1 343 TYR n 
1 344 LYS n 
1 345 ASN n 
1 346 LYS n 
1 347 THR n 
1 348 GLY n 
1 349 PRO n 
1 350 SER n 
1 351 SER n 
1 352 TYR n 
1 353 TYR n 
1 354 PRO n 
1 355 GLY n 
1 356 VAL n 
1 357 ALA n 
1 358 SER n 
1 359 GLY n 
1 360 PHE n 
1 361 VAL n 
1 362 SER n 
1 363 SER n 
1 364 ASP n 
1 365 GLY n 
1 366 THR n 
1 367 LYS n 
1 368 THR n 
1 369 GLY n 
1 370 ALA n 
1 371 ASP n 
1 372 PHE n 
1 373 GLU n 
1 374 LEU n 
1 375 ILE n 
1 376 PHE n 
1 377 THR n 
1 378 TYR n 
1 379 THR n 
1 380 HIS n 
1 381 GLY n 
1 382 ALA n 
1 383 ASP n 
1 384 GLY n 
1 385 THR n 
1 386 GLU n 
1 387 LYS n 
1 388 GLU n 
1 389 PHE n 
1 390 ALA n 
1 391 ASN n 
1 392 ILE n 
1 393 GLU n 
1 394 ASP n 
1 395 ILE n 
1 396 GLN n 
1 397 ALA n 
1 398 GLN n 
1 399 SER n 
1 400 GLY n 
1 401 TYR n 
1 402 SER n 
1 403 VAL n 
1 404 THR n 
1 405 VAL n 
1 406 ILE n 
1 407 LEU n 
1 408 LEU n 
1 409 GLN n 
1 410 PRO n 
1 411 LYS n 
1 412 SER n 
1 413 ARG n 
1 414 GLY n 
1 415 GLN n 
1 416 LEU n 
1 417 LEU n 
1 418 LEU n 
1 419 ALA n 
1 420 SER n 
1 421 THR n 
1 422 ASN n 
1 423 PRO n 
1 424 TYR n 
1 425 ASP n 
1 426 ALA n 
1 427 PRO n 
1 428 LEU n 
1 429 ILE n 
1 430 ASN n 
1 431 PRO n 
1 432 ARG n 
1 433 TYR n 
1 434 PHE n 
1 435 SER n 
1 436 ASP n 
1 437 SER n 
1 438 SER n 
1 439 ASP n 
1 440 MET n 
1 441 GLU n 
1 442 ARG n 
1 443 PHE n 
1 444 ILE n 
1 445 LYS n 
1 446 GLY n 
1 447 VAL n 
1 448 ARG n 
1 449 TYR n 
1 450 THR n 
1 451 GLN n 
1 452 LYS n 
1 453 ILE n 
1 454 THR n 
1 455 LYS n 
1 456 THR n 
1 457 GLU n 
1 458 SER n 
1 459 LEU n 
1 460 GLU n 
1 461 PRO n 
1 462 TYR n 
1 463 THR n 
1 464 TYR n 
1 465 LEU n 
1 466 ALA n 
1 467 HIS n 
1 468 PRO n 
1 469 ALA n 
1 470 LEU n 
1 471 ASP n 
1 472 ALA n 
1 473 THR n 
1 474 ASP n 
1 475 GLU n 
1 476 ILE n 
1 477 ILE n 
1 478 GLU n 
1 479 SER n 
1 480 LEU n 
1 481 ILE n 
1 482 ARG n 
1 483 ASN n 
1 484 GLU n 
1 485 ALA n 
1 486 SER n 
1 487 THR n 
1 488 VAL n 
1 489 PHE n 
1 490 HIS n 
1 491 PRO n 
1 492 VAL n 
1 493 GLY n 
1 494 THR n 
1 495 ALA n 
1 496 ARG n 
1 497 MET n 
1 498 GLY n 
1 499 ASP n 
1 500 VAL n 
1 501 GLU n 
1 502 ASN n 
1 503 ASP n 
1 504 SER n 
1 505 LEU n 
1 506 ALA n 
1 507 VAL n 
1 508 VAL n 
1 509 ASP n 
1 510 SER n 
1 511 SER n 
1 512 LEU n 
1 513 LYS n 
1 514 VAL n 
1 515 ARG n 
1 516 GLY n 
1 517 ILE n 
1 518 GLN n 
1 519 GLY n 
1 520 LEU n 
1 521 ARG n 
1 522 VAL n 
1 523 ALA n 
1 524 ASP n 
1 525 ALA n 
1 526 SER n 
1 527 ILE n 
1 528 ILE n 
1 529 PRO n 
1 530 ALA n 
1 531 VAL n 
1 532 ASN n 
1 533 ARG n 
1 534 GLY n 
1 535 HIS n 
1 536 THR n 
1 537 MET n 
1 538 ALA n 
1 539 PRO n 
1 540 VAL n 
1 541 VAL n 
1 542 TYR n 
1 543 VAL n 
1 544 GLY n 
1 545 GLU n 
1 546 MET n 
1 547 ALA n 
1 548 SER n 
1 549 GLU n 
1 550 ILE n 
1 551 ILE n 
1 552 ILE n 
1 553 ASN n 
1 554 ASP n 
1 555 ASN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   555 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Sphingobacterium daejeonense' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     371142 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
1BO non-polymer         . 1-BUTANOL                     BUTAN-1-OL 'C4 H10 O'          74.122  
ALA 'L-peptide linking' y ALANINE                       ?          'C3 H7 N O2'        89.093  
ARG 'L-peptide linking' y ARGININE                      ?          'C6 H15 N4 O2 1'    175.209 
ASN 'L-peptide linking' y ASPARAGINE                    ?          'C4 H8 N2 O3'       132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'               ?          'C4 H7 N O4'        133.103 
FAD non-polymer         . 'FLAVIN-ADENINE DINUCLEOTIDE' ?          'C27 H33 N9 O15 P2' 785.550 
GLN 'L-peptide linking' y GLUTAMINE                     ?          'C5 H10 N2 O3'      146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'               ?          'C5 H9 N O4'        147.129 
GLY 'peptide linking'   y GLYCINE                       ?          'C2 H5 N O2'        75.067  
HEZ non-polymer         . HEXANE-1,6-DIOL               ?          'C6 H14 O2'         118.174 
HIS 'L-peptide linking' y HISTIDINE                     ?          'C6 H10 N3 O2 1'    156.162 
HOH non-polymer         . WATER                         ?          'H2 O'              18.015  
ILE 'L-peptide linking' y ISOLEUCINE                    ?          'C6 H13 N O2'       131.173 
LEU 'L-peptide linking' y LEUCINE                       ?          'C6 H13 N O2'       131.173 
LYS 'L-peptide linking' y LYSINE                        ?          'C6 H15 N2 O2 1'    147.195 
MET 'L-peptide linking' y METHIONINE                    ?          'C5 H11 N O2 S'     149.211 
PHE 'L-peptide linking' y PHENYLALANINE                 ?          'C9 H11 N O2'       165.189 
PRO 'L-peptide linking' y PROLINE                       ?          'C5 H9 N O2'        115.130 
SER 'L-peptide linking' y SERINE                        ?          'C3 H7 N O3'        105.093 
THR 'L-peptide linking' y THREONINE                     ?          'C4 H9 N O3'        119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                    ?          'C11 H12 N2 O2'     204.225 
TYR 'L-peptide linking' y TYROSINE                      ?          'C9 H11 N O3'       181.189 
VAL 'L-peptide linking' y VALINE                        ?          'C5 H11 N O2'       117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -20 ?   ?   ?   A . n 
A 1 2   GLY 2   -19 ?   ?   ?   A . n 
A 1 3   SER 3   -18 ?   ?   ?   A . n 
A 1 4   SER 4   -17 ?   ?   ?   A . n 
A 1 5   HIS 5   -16 ?   ?   ?   A . n 
A 1 6   HIS 6   -15 ?   ?   ?   A . n 
A 1 7   HIS 7   -14 ?   ?   ?   A . n 
A 1 8   HIS 8   -13 ?   ?   ?   A . n 
A 1 9   HIS 9   -12 ?   ?   ?   A . n 
A 1 10  HIS 10  -11 ?   ?   ?   A . n 
A 1 11  SER 11  -10 ?   ?   ?   A . n 
A 1 12  SER 12  -9  ?   ?   ?   A . n 
A 1 13  GLY 13  -8  ?   ?   ?   A . n 
A 1 14  LEU 14  -7  ?   ?   ?   A . n 
A 1 15  VAL 15  -6  ?   ?   ?   A . n 
A 1 16  PRO 16  -5  ?   ?   ?   A . n 
A 1 17  ARG 17  -4  ?   ?   ?   A . n 
A 1 18  GLY 18  -3  ?   ?   ?   A . n 
A 1 19  SER 19  -2  ?   ?   ?   A . n 
A 1 20  HIS 20  -1  ?   ?   ?   A . n 
A 1 21  MET 21  0   ?   ?   ?   A . n 
A 1 22  LYS 22  1   1   LYS LYS A . n 
A 1 23  LYS 23  2   2   LYS LYS A . n 
A 1 24  PHE 24  3   3   PHE PHE A . n 
A 1 25  ASP 25  4   4   ASP ASP A . n 
A 1 26  PHE 26  5   5   PHE PHE A . n 
A 1 27  ILE 27  6   6   ILE ILE A . n 
A 1 28  ILE 28  7   7   ILE ILE A . n 
A 1 29  VAL 29  8   8   VAL VAL A . n 
A 1 30  GLY 30  9   9   GLY GLY A . n 
A 1 31  ALA 31  10  10  ALA ALA A . n 
A 1 32  GLY 32  11  11  GLY GLY A . n 
A 1 33  THR 33  12  12  THR THR A . n 
A 1 34  ALA 34  13  13  ALA ALA A . n 
A 1 35  GLY 35  14  14  GLY GLY A . n 
A 1 36  PRO 36  15  15  PRO PRO A . n 
A 1 37  VAL 37  16  16  VAL VAL A . n 
A 1 38  ILE 38  17  17  ILE ILE A . n 
A 1 39  ALA 39  18  18  ALA ALA A . n 
A 1 40  SER 40  19  19  SER SER A . n 
A 1 41  ARG 41  20  20  ARG ARG A . n 
A 1 42  LEU 42  21  21  LEU LEU A . n 
A 1 43  THR 43  22  22  THR THR A . n 
A 1 44  GLU 44  23  23  GLU GLU A . n 
A 1 45  LYS 45  24  24  LYS LYS A . n 
A 1 46  GLU 46  25  25  GLU GLU A . n 
A 1 47  HIS 47  26  26  HIS HIS A . n 
A 1 48  ILE 48  27  27  ILE ILE A . n 
A 1 49  ASN 49  28  28  ASN ASN A . n 
A 1 50  VAL 50  29  29  VAL VAL A . n 
A 1 51  LEU 51  30  30  LEU LEU A . n 
A 1 52  LEU 52  31  31  LEU LEU A . n 
A 1 53  LEU 53  32  32  LEU LEU A . n 
A 1 54  GLU 54  33  33  GLU GLU A . n 
A 1 55  ALA 55  34  34  ALA ALA A . n 
A 1 56  GLY 56  35  35  GLY GLY A . n 
A 1 57  GLY 57  36  36  GLY GLY A . n 
A 1 58  GLU 58  37  37  GLU GLU A . n 
A 1 59  ASN 59  38  38  ASN ASN A . n 
A 1 60  THR 60  39  39  THR THR A . n 
A 1 61  ASN 61  40  40  ASN ASN A . n 
A 1 62  GLU 62  41  41  GLU GLU A . n 
A 1 63  LEU 63  42  42  LEU LEU A . n 
A 1 64  SER 64  43  43  SER SER A . n 
A 1 65  ARG 65  44  44  ARG ARG A . n 
A 1 66  ILE 66  45  45  ILE ILE A . n 
A 1 67  PRO 67  46  46  PRO PRO A . n 
A 1 68  GLY 68  47  47  GLY GLY A . n 
A 1 69  ALA 69  48  48  ALA ALA A . n 
A 1 70  PHE 70  49  49  PHE PHE A . n 
A 1 71  PHE 71  50  50  PHE PHE A . n 
A 1 72  LYS 72  51  51  LYS LYS A . n 
A 1 73  VAL 73  52  52  VAL VAL A . n 
A 1 74  LEU 74  53  53  LEU LEU A . n 
A 1 75  GLY 75  54  54  GLY GLY A . n 
A 1 76  THR 76  55  55  THR THR A . n 
A 1 77  ASP 77  56  56  ASP ASP A . n 
A 1 78  TYR 78  57  57  TYR TYR A . n 
A 1 79  ASP 79  58  58  ASP ASP A . n 
A 1 80  TRP 80  59  59  TRP TRP A . n 
A 1 81  THR 81  60  60  THR THR A . n 
A 1 82  TYR 82  61  61  TYR TYR A . n 
A 1 83  SER 83  62  62  SER SER A . n 
A 1 84  SER 84  63  63  SER SER A . n 
A 1 85  VAL 85  64  64  VAL VAL A . n 
A 1 86  GLU 86  65  65  GLU GLU A . n 
A 1 87  GLN 87  66  66  GLN GLN A . n 
A 1 88  THR 88  67  67  THR THR A . n 
A 1 89  GLY 89  68  68  GLY GLY A . n 
A 1 90  LEU 90  69  69  LEU LEU A . n 
A 1 91  ASN 91  70  70  ASN ASN A . n 
A 1 92  ASN 92  71  71  ASN ASN A . n 
A 1 93  ARG 93  72  72  ARG ARG A . n 
A 1 94  SER 94  73  73  SER SER A . n 
A 1 95  ILE 95  74  74  ILE ILE A . n 
A 1 96  TYR 96  75  75  TYR TYR A . n 
A 1 97  SER 97  76  76  SER SER A . n 
A 1 98  PRO 98  77  77  PRO PRO A . n 
A 1 99  SER 99  78  78  SER SER A . n 
A 1 100 GLY 100 79  79  GLY GLY A . n 
A 1 101 LYS 101 80  80  LYS LYS A . n 
A 1 102 VAL 102 81  81  VAL VAL A . n 
A 1 103 VAL 103 82  82  VAL VAL A . n 
A 1 104 GLY 104 83  83  GLY GLY A . n 
A 1 105 GLY 105 84  84  GLY GLY A . n 
A 1 106 SER 106 85  85  SER SER A . n 
A 1 107 SER 107 86  86  SER SER A . n 
A 1 108 ALA 108 87  87  ALA ALA A . n 
A 1 109 ILE 109 88  88  ILE ILE A . n 
A 1 110 ASN 110 89  89  ASN ASN A . n 
A 1 111 VAL 111 90  90  VAL VAL A . n 
A 1 112 GLY 112 91  91  GLY GLY A . n 
A 1 113 VAL 113 92  92  VAL VAL A . n 
A 1 114 TRP 114 93  93  TRP TRP A . n 
A 1 115 VAL 115 94  94  VAL VAL A . n 
A 1 116 ARG 116 95  95  ARG ARG A . n 
A 1 117 GLY 117 96  96  GLY GLY A . n 
A 1 118 THR 118 97  97  THR THR A . n 
A 1 119 LYS 119 98  98  LYS LYS A . n 
A 1 120 GLU 120 99  99  GLU GLU A . n 
A 1 121 ASP 121 100 100 ASP ASP A . n 
A 1 122 TYR 122 101 101 TYR TYR A . n 
A 1 123 ASP 123 102 102 ASP ASP A . n 
A 1 124 SER 124 103 103 SER SER A . n 
A 1 125 TRP 125 104 104 TRP TRP A . n 
A 1 126 GLU 126 105 105 GLU GLU A . n 
A 1 127 ALA 127 106 106 ALA ALA A . n 
A 1 128 GLN 128 107 107 GLN GLN A . n 
A 1 129 GLY 129 108 108 GLY GLY A . n 
A 1 130 ALA 130 109 109 ALA ALA A . n 
A 1 131 LYS 131 110 110 LYS LYS A . n 
A 1 132 GLY 132 111 111 GLY GLY A . n 
A 1 133 TRP 133 112 112 TRP TRP A . n 
A 1 134 ASN 134 113 113 ASN ASN A . n 
A 1 135 PHE 135 114 114 PHE PHE A . n 
A 1 136 SER 136 115 115 SER SER A . n 
A 1 137 LYS 137 116 116 LYS LYS A . n 
A 1 138 ALA 138 117 117 ALA ALA A . n 
A 1 139 LEU 139 118 118 LEU LEU A . n 
A 1 140 GLU 140 119 119 GLU GLU A . n 
A 1 141 MET 141 120 120 MET MET A . n 
A 1 142 PHE 142 121 121 PHE PHE A . n 
A 1 143 GLN 143 122 122 GLN GLN A . n 
A 1 144 LYS 144 123 123 LYS LYS A . n 
A 1 145 ILE 145 124 124 ILE ILE A . n 
A 1 146 GLU 146 125 125 GLU GLU A . n 
A 1 147 GLN 147 126 126 GLN GLN A . n 
A 1 148 THR 148 127 127 THR THR A . n 
A 1 149 ASN 149 128 128 ASN ASN A . n 
A 1 150 LEU 150 129 129 LEU LEU A . n 
A 1 151 GLY 151 130 130 GLY GLY A . n 
A 1 152 PRO 152 131 131 PRO PRO A . n 
A 1 153 SER 153 132 132 SER SER A . n 
A 1 154 LYS 154 133 133 LYS LYS A . n 
A 1 155 TYR 155 134 134 TYR TYR A . n 
A 1 156 HIS 156 135 135 HIS HIS A . n 
A 1 157 GLY 157 136 136 GLY GLY A . n 
A 1 158 ASP 158 137 137 ASP ASP A . n 
A 1 159 LYS 159 138 138 LYS LYS A . n 
A 1 160 GLY 160 139 139 GLY GLY A . n 
A 1 161 LYS 161 140 140 LYS LYS A . n 
A 1 162 VAL 162 141 141 VAL VAL A . n 
A 1 163 LYS 163 142 142 LYS LYS A . n 
A 1 164 LEU 164 143 143 LEU LEU A . n 
A 1 165 THR 165 144 144 THR THR A . n 
A 1 166 ASP 166 145 145 ASP ASP A . n 
A 1 167 SER 167 146 146 SER SER A . n 
A 1 168 SER 168 147 147 SER SER A . n 
A 1 169 TYR 169 148 148 TYR TYR A . n 
A 1 170 PRO 170 149 149 PRO PRO A . n 
A 1 171 THR 171 150 150 THR THR A . n 
A 1 172 PRO 172 151 151 PRO PRO A . n 
A 1 173 PHE 173 152 152 PHE PHE A . n 
A 1 174 VAL 174 153 153 VAL VAL A . n 
A 1 175 HIS 175 154 154 HIS HIS A . n 
A 1 176 THR 176 155 155 THR THR A . n 
A 1 177 LEU 177 156 156 LEU LEU A . n 
A 1 178 LEU 178 157 157 LEU LEU A . n 
A 1 179 ASN 179 158 158 ASN ASN A . n 
A 1 180 GLY 180 159 159 GLY GLY A . n 
A 1 181 PHE 181 160 160 PHE PHE A . n 
A 1 182 LYS 182 161 161 LYS LYS A . n 
A 1 183 GLU 183 162 162 GLU GLU A . n 
A 1 184 ALA 184 163 163 ALA ALA A . n 
A 1 185 GLY 185 164 164 GLY GLY A . n 
A 1 186 PHE 186 165 165 PHE PHE A . n 
A 1 187 GLY 187 166 166 GLY GLY A . n 
A 1 188 GLU 188 167 167 GLU GLU A . n 
A 1 189 ILE 189 168 168 ILE ILE A . n 
A 1 190 GLY 190 169 169 GLY GLY A . n 
A 1 191 ASP 191 170 170 ASP ASP A . n 
A 1 192 TYR 192 171 171 TYR TYR A . n 
A 1 193 ALA 193 172 172 ALA ALA A . n 
A 1 194 GLY 194 173 173 GLY GLY A . n 
A 1 195 GLU 195 174 174 GLU GLU A . n 
A 1 196 ASN 196 175 175 ASN ASN A . n 
A 1 197 PRO 197 176 176 PRO PRO A . n 
A 1 198 TYR 198 177 177 TYR TYR A . n 
A 1 199 SER 199 178 178 SER SER A . n 
A 1 200 ILE 200 179 179 ILE ILE A . n 
A 1 201 ASP 201 180 180 ASP ASP A . n 
A 1 202 ILE 202 181 181 ILE ILE A . n 
A 1 203 MET 203 182 182 MET MET A . n 
A 1 204 GLN 204 183 183 GLN GLN A . n 
A 1 205 LYS 205 184 184 LYS LYS A . n 
A 1 206 ILE 206 185 185 ILE ILE A . n 
A 1 207 TYR 207 186 186 TYR TYR A . n 
A 1 208 GLU 208 187 187 GLU GLU A . n 
A 1 209 ASN 209 188 188 ASN ASN A . n 
A 1 210 ASN 210 189 189 ASN ASN A . n 
A 1 211 THR 211 190 190 THR THR A . n 
A 1 212 ARG 212 191 191 ARG ARG A . n 
A 1 213 ARG 213 192 192 ARG ARG A . n 
A 1 214 THR 214 193 193 THR THR A . n 
A 1 215 PRO 215 194 194 PRO PRO A . n 
A 1 216 ALA 216 195 195 ALA ALA A . n 
A 1 217 ASP 217 196 196 ASP ASP A . n 
A 1 218 SER 218 197 197 SER SER A . n 
A 1 219 TYR 219 198 198 TYR TYR A . n 
A 1 220 LEU 220 199 199 LEU LEU A . n 
A 1 221 THR 221 200 200 THR THR A . n 
A 1 222 GLU 222 201 201 GLU GLU A . n 
A 1 223 ASP 223 202 202 ASP ASP A . n 
A 1 224 VAL 224 203 203 VAL VAL A . n 
A 1 225 ARG 225 204 204 ARG ARG A . n 
A 1 226 ALA 226 205 205 ALA ALA A . n 
A 1 227 ARG 227 206 206 ARG ARG A . n 
A 1 228 GLU 228 207 207 GLU GLU A . n 
A 1 229 ASN 229 208 208 ASN ASN A . n 
A 1 230 LEU 230 209 209 LEU LEU A . n 
A 1 231 THR 231 210 210 THR THR A . n 
A 1 232 ILE 232 211 211 ILE ILE A . n 
A 1 233 ILE 233 212 212 ILE ILE A . n 
A 1 234 THR 234 213 213 THR THR A . n 
A 1 235 HIS 235 214 214 HIS HIS A . n 
A 1 236 ALA 236 215 215 ALA ALA A . n 
A 1 237 PHE 237 216 216 PHE PHE A . n 
A 1 238 VAL 238 217 217 VAL VAL A . n 
A 1 239 ARG 239 218 218 ARG ARG A . n 
A 1 240 LYS 240 219 219 LYS LYS A . n 
A 1 241 VAL 241 220 220 VAL VAL A . n 
A 1 242 LEU 242 221 221 LEU LEU A . n 
A 1 243 PHE 243 222 222 PHE PHE A . n 
A 1 244 GLU 244 223 223 GLU GLU A . n 
A 1 245 GLY 245 224 224 GLY GLY A . n 
A 1 246 THR 246 225 225 THR THR A . n 
A 1 247 LYS 247 226 226 LYS LYS A . n 
A 1 248 ALA 248 227 227 ALA ALA A . n 
A 1 249 ILE 249 228 228 ILE ILE A . n 
A 1 250 GLY 250 229 229 GLY GLY A . n 
A 1 251 VAL 251 230 230 VAL VAL A . n 
A 1 252 GLU 252 231 231 GLU GLU A . n 
A 1 253 VAL 253 232 232 VAL VAL A . n 
A 1 254 GLU 254 233 233 GLU GLU A . n 
A 1 255 ILE 255 234 234 ILE ILE A . n 
A 1 256 ASP 256 235 235 ASP ASP A . n 
A 1 257 GLY 257 236 236 GLY GLY A . n 
A 1 258 GLN 258 237 237 GLN GLN A . n 
A 1 259 ILE 259 238 238 ILE ILE A . n 
A 1 260 GLN 260 239 239 GLN GLN A . n 
A 1 261 ASN 261 240 240 ASN ASN A . n 
A 1 262 MET 262 241 241 MET MET A . n 
A 1 263 TYR 263 242 242 TYR TYR A . n 
A 1 264 ALA 264 243 243 ALA ALA A . n 
A 1 265 SER 265 244 244 SER SER A . n 
A 1 266 LYS 266 245 245 LYS LYS A . n 
A 1 267 GLU 267 246 246 GLU GLU A . n 
A 1 268 ILE 268 247 247 ILE ILE A . n 
A 1 269 ILE 269 248 248 ILE ILE A . n 
A 1 270 LEU 270 249 249 LEU LEU A . n 
A 1 271 SER 271 250 250 SER SER A . n 
A 1 272 ALA 272 251 251 ALA ALA A . n 
A 1 273 GLY 273 252 252 GLY GLY A . n 
A 1 274 THR 274 253 253 THR THR A . n 
A 1 275 PHE 275 254 254 PHE PHE A . n 
A 1 276 ASN 276 255 255 ASN ASN A . n 
A 1 277 THR 277 256 256 THR THR A . n 
A 1 278 PRO 278 257 257 PRO PRO A . n 
A 1 279 LYS 279 258 258 LYS LYS A . n 
A 1 280 LEU 280 259 259 LEU LEU A . n 
A 1 281 LEU 281 260 260 LEU LEU A . n 
A 1 282 LYS 282 261 261 LYS LYS A . n 
A 1 283 LEU 283 262 262 LEU LEU A . n 
A 1 284 SER 284 263 263 SER SER A . n 
A 1 285 GLY 285 264 264 GLY GLY A . n 
A 1 286 VAL 286 265 265 VAL VAL A . n 
A 1 287 GLY 287 266 266 GLY GLY A . n 
A 1 288 PRO 288 267 267 PRO PRO A . n 
A 1 289 ARG 289 268 268 ARG ARG A . n 
A 1 290 GLU 290 269 269 GLU GLU A . n 
A 1 291 GLU 291 270 270 GLU GLU A . n 
A 1 292 LEU 292 271 271 LEU LEU A . n 
A 1 293 GLU 293 272 272 GLU GLU A . n 
A 1 294 LYS 294 273 273 LYS LYS A . n 
A 1 295 PHE 295 274 274 PHE PHE A . n 
A 1 296 GLY 296 275 275 GLY GLY A . n 
A 1 297 ILE 297 276 276 ILE ILE A . n 
A 1 298 PRO 298 277 277 PRO PRO A . n 
A 1 299 VAL 299 278 278 VAL VAL A . n 
A 1 300 ILE 300 279 279 ILE ILE A . n 
A 1 301 ALA 301 280 280 ALA ALA A . n 
A 1 302 ASN 302 281 281 ASN ASN A . n 
A 1 303 VAL 303 282 282 VAL VAL A . n 
A 1 304 PRO 304 283 283 PRO PRO A . n 
A 1 305 GLY 305 284 284 GLY GLY A . n 
A 1 306 VAL 306 285 285 VAL VAL A . n 
A 1 307 GLY 307 286 286 GLY GLY A . n 
A 1 308 GLU 308 287 287 GLU GLU A . n 
A 1 309 ASN 309 288 288 ASN ASN A . n 
A 1 310 LEU 310 289 289 LEU LEU A . n 
A 1 311 ASN 311 290 290 ASN ASN A . n 
A 1 312 ASP 312 291 291 ASP ASP A . n 
A 1 313 HIS 313 292 292 HIS HIS A . n 
A 1 314 LEU 314 293 293 LEU LEU A . n 
A 1 315 MET 315 294 294 MET MET A . n 
A 1 316 PHE 316 295 295 PHE PHE A . n 
A 1 317 THR 317 296 296 THR THR A . n 
A 1 318 LEU 318 297 297 LEU LEU A . n 
A 1 319 LYS 319 298 298 LYS LYS A . n 
A 1 320 PHE 320 299 299 PHE PHE A . n 
A 1 321 VAL 321 300 300 VAL VAL A . n 
A 1 322 SER 322 301 301 SER SER A . n 
A 1 323 GLU 323 302 302 GLU GLU A . n 
A 1 324 LYS 324 303 303 LYS LYS A . n 
A 1 325 ASN 325 304 304 ASN ASN A . n 
A 1 326 ILE 326 305 305 ILE ILE A . n 
A 1 327 GLU 327 306 306 GLU GLU A . n 
A 1 328 ASP 328 307 307 ASP ASP A . n 
A 1 329 SER 329 308 308 SER SER A . n 
A 1 330 ILE 330 309 309 ILE ILE A . n 
A 1 331 PHE 331 310 310 PHE PHE A . n 
A 1 332 ASN 332 311 311 ASN ASN A . n 
A 1 333 PRO 333 312 312 PRO PRO A . n 
A 1 334 LEU 334 313 313 LEU LEU A . n 
A 1 335 SER 335 314 314 SER SER A . n 
A 1 336 ASP 336 315 315 ASP ASP A . n 
A 1 337 GLU 337 316 316 GLU GLU A . n 
A 1 338 ALA 338 317 317 ALA ALA A . n 
A 1 339 ILE 339 318 318 ILE ILE A . n 
A 1 340 ASP 340 319 319 ASP ASP A . n 
A 1 341 GLN 341 320 320 GLN GLN A . n 
A 1 342 TRP 342 321 321 TRP TRP A . n 
A 1 343 TYR 343 322 322 TYR TYR A . n 
A 1 344 LYS 344 323 323 LYS LYS A . n 
A 1 345 ASN 345 324 324 ASN ASN A . n 
A 1 346 LYS 346 325 325 LYS LYS A . n 
A 1 347 THR 347 326 326 THR THR A . n 
A 1 348 GLY 348 327 327 GLY GLY A . n 
A 1 349 PRO 349 328 328 PRO PRO A . n 
A 1 350 SER 350 329 329 SER SER A . n 
A 1 351 SER 351 330 330 SER SER A . n 
A 1 352 TYR 352 331 331 TYR TYR A . n 
A 1 353 TYR 353 332 332 TYR TYR A . n 
A 1 354 PRO 354 333 333 PRO PRO A . n 
A 1 355 GLY 355 334 334 GLY GLY A . n 
A 1 356 VAL 356 335 335 VAL VAL A . n 
A 1 357 ALA 357 336 336 ALA ALA A . n 
A 1 358 SER 358 337 337 SER SER A . n 
A 1 359 GLY 359 338 338 GLY GLY A . n 
A 1 360 PHE 360 339 339 PHE PHE A . n 
A 1 361 VAL 361 340 340 VAL VAL A . n 
A 1 362 SER 362 341 341 SER SER A . n 
A 1 363 SER 363 342 342 SER SER A . n 
A 1 364 ASP 364 343 343 ASP ASP A . n 
A 1 365 GLY 365 344 344 GLY GLY A . n 
A 1 366 THR 366 345 345 THR THR A . n 
A 1 367 LYS 367 346 346 LYS LYS A . n 
A 1 368 THR 368 347 347 THR THR A . n 
A 1 369 GLY 369 348 348 GLY GLY A . n 
A 1 370 ALA 370 349 349 ALA ALA A . n 
A 1 371 ASP 371 350 350 ASP ASP A . n 
A 1 372 PHE 372 351 351 PHE PHE A . n 
A 1 373 GLU 373 352 352 GLU GLU A . n 
A 1 374 LEU 374 353 353 LEU LEU A . n 
A 1 375 ILE 375 354 354 ILE ILE A . n 
A 1 376 PHE 376 355 355 PHE PHE A . n 
A 1 377 THR 377 356 356 THR THR A . n 
A 1 378 TYR 378 357 357 TYR TYR A . n 
A 1 379 THR 379 358 358 THR THR A . n 
A 1 380 HIS 380 359 359 HIS HIS A . n 
A 1 381 GLY 381 360 360 GLY GLY A . n 
A 1 382 ALA 382 361 361 ALA ALA A . n 
A 1 383 ASP 383 362 362 ASP ASP A . n 
A 1 384 GLY 384 363 363 GLY GLY A . n 
A 1 385 THR 385 364 364 THR THR A . n 
A 1 386 GLU 386 365 365 GLU GLU A . n 
A 1 387 LYS 387 366 366 LYS LYS A . n 
A 1 388 GLU 388 367 367 GLU GLU A . n 
A 1 389 PHE 389 368 368 PHE PHE A . n 
A 1 390 ALA 390 369 369 ALA ALA A . n 
A 1 391 ASN 391 370 370 ASN ASN A . n 
A 1 392 ILE 392 371 371 ILE ILE A . n 
A 1 393 GLU 393 372 372 GLU GLU A . n 
A 1 394 ASP 394 373 373 ASP ASP A . n 
A 1 395 ILE 395 374 374 ILE ILE A . n 
A 1 396 GLN 396 375 375 GLN GLN A . n 
A 1 397 ALA 397 376 376 ALA ALA A . n 
A 1 398 GLN 398 377 377 GLN GLN A . n 
A 1 399 SER 399 378 378 SER SER A . n 
A 1 400 GLY 400 379 379 GLY GLY A . n 
A 1 401 TYR 401 380 380 TYR TYR A . n 
A 1 402 SER 402 381 381 SER SER A . n 
A 1 403 VAL 403 382 382 VAL VAL A . n 
A 1 404 THR 404 383 383 THR THR A . n 
A 1 405 VAL 405 384 384 VAL VAL A . n 
A 1 406 ILE 406 385 385 ILE ILE A . n 
A 1 407 LEU 407 386 386 LEU LEU A . n 
A 1 408 LEU 408 387 387 LEU LEU A . n 
A 1 409 GLN 409 388 388 GLN GLN A . n 
A 1 410 PRO 410 389 389 PRO PRO A . n 
A 1 411 LYS 411 390 390 LYS LYS A . n 
A 1 412 SER 412 391 391 SER SER A . n 
A 1 413 ARG 413 392 392 ARG ARG A . n 
A 1 414 GLY 414 393 393 GLY GLY A . n 
A 1 415 GLN 415 394 394 GLN GLN A . n 
A 1 416 LEU 416 395 395 LEU LEU A . n 
A 1 417 LEU 417 396 396 LEU LEU A . n 
A 1 418 LEU 418 397 397 LEU LEU A . n 
A 1 419 ALA 419 398 398 ALA ALA A . n 
A 1 420 SER 420 399 399 SER SER A . n 
A 1 421 THR 421 400 400 THR THR A . n 
A 1 422 ASN 422 401 401 ASN ASN A . n 
A 1 423 PRO 423 402 402 PRO PRO A . n 
A 1 424 TYR 424 403 403 TYR TYR A . n 
A 1 425 ASP 425 404 404 ASP ASP A . n 
A 1 426 ALA 426 405 405 ALA ALA A . n 
A 1 427 PRO 427 406 406 PRO PRO A . n 
A 1 428 LEU 428 407 407 LEU LEU A . n 
A 1 429 ILE 429 408 408 ILE ILE A . n 
A 1 430 ASN 430 409 409 ASN ASN A . n 
A 1 431 PRO 431 410 410 PRO PRO A . n 
A 1 432 ARG 432 411 411 ARG ARG A . n 
A 1 433 TYR 433 412 412 TYR TYR A . n 
A 1 434 PHE 434 413 413 PHE PHE A . n 
A 1 435 SER 435 414 414 SER SER A . n 
A 1 436 ASP 436 415 415 ASP ASP A . n 
A 1 437 SER 437 416 416 SER SER A . n 
A 1 438 SER 438 417 417 SER SER A . n 
A 1 439 ASP 439 418 418 ASP ASP A . n 
A 1 440 MET 440 419 419 MET MET A . n 
A 1 441 GLU 441 420 420 GLU GLU A . n 
A 1 442 ARG 442 421 421 ARG ARG A . n 
A 1 443 PHE 443 422 422 PHE PHE A . n 
A 1 444 ILE 444 423 423 ILE ILE A . n 
A 1 445 LYS 445 424 424 LYS LYS A . n 
A 1 446 GLY 446 425 425 GLY GLY A . n 
A 1 447 VAL 447 426 426 VAL VAL A . n 
A 1 448 ARG 448 427 427 ARG ARG A . n 
A 1 449 TYR 449 428 428 TYR TYR A . n 
A 1 450 THR 450 429 429 THR THR A . n 
A 1 451 GLN 451 430 430 GLN GLN A . n 
A 1 452 LYS 452 431 431 LYS LYS A . n 
A 1 453 ILE 453 432 432 ILE ILE A . n 
A 1 454 THR 454 433 433 THR THR A . n 
A 1 455 LYS 455 434 434 LYS LYS A . n 
A 1 456 THR 456 435 435 THR THR A . n 
A 1 457 GLU 457 436 436 GLU GLU A . n 
A 1 458 SER 458 437 437 SER SER A . n 
A 1 459 LEU 459 438 438 LEU LEU A . n 
A 1 460 GLU 460 439 439 GLU GLU A . n 
A 1 461 PRO 461 440 440 PRO PRO A . n 
A 1 462 TYR 462 441 441 TYR TYR A . n 
A 1 463 THR 463 442 442 THR THR A . n 
A 1 464 TYR 464 443 443 TYR TYR A . n 
A 1 465 LEU 465 444 444 LEU LEU A . n 
A 1 466 ALA 466 445 445 ALA ALA A . n 
A 1 467 HIS 467 446 446 HIS HIS A . n 
A 1 468 PRO 468 447 447 PRO PRO A . n 
A 1 469 ALA 469 448 448 ALA ALA A . n 
A 1 470 LEU 470 449 449 LEU LEU A . n 
A 1 471 ASP 471 450 450 ASP ASP A . n 
A 1 472 ALA 472 451 451 ALA ALA A . n 
A 1 473 THR 473 452 452 THR THR A . n 
A 1 474 ASP 474 453 453 ASP ASP A . n 
A 1 475 GLU 475 454 454 GLU GLU A . n 
A 1 476 ILE 476 455 455 ILE ILE A . n 
A 1 477 ILE 477 456 456 ILE ILE A . n 
A 1 478 GLU 478 457 457 GLU GLU A . n 
A 1 479 SER 479 458 458 SER SER A . n 
A 1 480 LEU 480 459 459 LEU LEU A . n 
A 1 481 ILE 481 460 460 ILE ILE A . n 
A 1 482 ARG 482 461 461 ARG ARG A . n 
A 1 483 ASN 483 462 462 ASN ASN A . n 
A 1 484 GLU 484 463 463 GLU GLU A . n 
A 1 485 ALA 485 464 464 ALA ALA A . n 
A 1 486 SER 486 465 465 SER SER A . n 
A 1 487 THR 487 466 466 THR THR A . n 
A 1 488 VAL 488 467 467 VAL VAL A . n 
A 1 489 PHE 489 468 468 PHE PHE A . n 
A 1 490 HIS 490 469 469 HIS HIS A . n 
A 1 491 PRO 491 470 470 PRO PRO A . n 
A 1 492 VAL 492 471 471 VAL VAL A . n 
A 1 493 GLY 493 472 472 GLY GLY A . n 
A 1 494 THR 494 473 473 THR THR A . n 
A 1 495 ALA 495 474 474 ALA ALA A . n 
A 1 496 ARG 496 475 475 ARG ARG A . n 
A 1 497 MET 497 476 476 MET MET A . n 
A 1 498 GLY 498 477 477 GLY GLY A . n 
A 1 499 ASP 499 478 478 ASP ASP A . n 
A 1 500 VAL 500 479 479 VAL VAL A . n 
A 1 501 GLU 501 480 480 GLU GLU A . n 
A 1 502 ASN 502 481 481 ASN ASN A . n 
A 1 503 ASP 503 482 482 ASP ASP A . n 
A 1 504 SER 504 483 483 SER SER A . n 
A 1 505 LEU 505 484 484 LEU LEU A . n 
A 1 506 ALA 506 485 485 ALA ALA A . n 
A 1 507 VAL 507 486 486 VAL VAL A . n 
A 1 508 VAL 508 487 487 VAL VAL A . n 
A 1 509 ASP 509 488 488 ASP ASP A . n 
A 1 510 SER 510 489 489 SER SER A . n 
A 1 511 SER 511 490 490 SER SER A . n 
A 1 512 LEU 512 491 491 LEU LEU A . n 
A 1 513 LYS 513 492 492 LYS LYS A . n 
A 1 514 VAL 514 493 493 VAL VAL A . n 
A 1 515 ARG 515 494 494 ARG ARG A . n 
A 1 516 GLY 516 495 495 GLY GLY A . n 
A 1 517 ILE 517 496 496 ILE ILE A . n 
A 1 518 GLN 518 497 497 GLN GLN A . n 
A 1 519 GLY 519 498 498 GLY GLY A . n 
A 1 520 LEU 520 499 499 LEU LEU A . n 
A 1 521 ARG 521 500 500 ARG ARG A . n 
A 1 522 VAL 522 501 501 VAL VAL A . n 
A 1 523 ALA 523 502 502 ALA ALA A . n 
A 1 524 ASP 524 503 503 ASP ASP A . n 
A 1 525 ALA 525 504 504 ALA ALA A . n 
A 1 526 SER 526 505 505 SER SER A . n 
A 1 527 ILE 527 506 506 ILE ILE A . n 
A 1 528 ILE 528 507 507 ILE ILE A . n 
A 1 529 PRO 529 508 508 PRO PRO A . n 
A 1 530 ALA 530 509 509 ALA ALA A . n 
A 1 531 VAL 531 510 510 VAL VAL A . n 
A 1 532 ASN 532 511 511 ASN ASN A . n 
A 1 533 ARG 533 512 512 ARG ARG A . n 
A 1 534 GLY 534 513 513 GLY GLY A . n 
A 1 535 HIS 535 514 514 HIS HIS A . n 
A 1 536 THR 536 515 515 THR THR A . n 
A 1 537 MET 537 516 516 MET MET A . n 
A 1 538 ALA 538 517 517 ALA ALA A . n 
A 1 539 PRO 539 518 518 PRO PRO A . n 
A 1 540 VAL 540 519 519 VAL VAL A . n 
A 1 541 VAL 541 520 520 VAL VAL A . n 
A 1 542 TYR 542 521 521 TYR TYR A . n 
A 1 543 VAL 543 522 522 VAL VAL A . n 
A 1 544 GLY 544 523 523 GLY GLY A . n 
A 1 545 GLU 545 524 524 GLU GLU A . n 
A 1 546 MET 546 525 525 MET MET A . n 
A 1 547 ALA 547 526 526 ALA ALA A . n 
A 1 548 SER 548 527 527 SER SER A . n 
A 1 549 GLU 549 528 528 GLU GLU A . n 
A 1 550 ILE 550 529 529 ILE ILE A . n 
A 1 551 ILE 551 530 530 ILE ILE A . n 
A 1 552 ILE 552 531 531 ILE ILE A . n 
A 1 553 ASN 553 532 532 ASN ASN A . n 
A 1 554 ASP 554 533 533 ASP ASP A . n 
A 1 555 ASN 555 534 534 ASN ASN A . n 
B 1 1   MET 1   -20 ?   ?   ?   B . n 
B 1 2   GLY 2   -19 ?   ?   ?   B . n 
B 1 3   SER 3   -18 ?   ?   ?   B . n 
B 1 4   SER 4   -17 ?   ?   ?   B . n 
B 1 5   HIS 5   -16 ?   ?   ?   B . n 
B 1 6   HIS 6   -15 ?   ?   ?   B . n 
B 1 7   HIS 7   -14 ?   ?   ?   B . n 
B 1 8   HIS 8   -13 ?   ?   ?   B . n 
B 1 9   HIS 9   -12 ?   ?   ?   B . n 
B 1 10  HIS 10  -11 ?   ?   ?   B . n 
B 1 11  SER 11  -10 ?   ?   ?   B . n 
B 1 12  SER 12  -9  ?   ?   ?   B . n 
B 1 13  GLY 13  -8  ?   ?   ?   B . n 
B 1 14  LEU 14  -7  ?   ?   ?   B . n 
B 1 15  VAL 15  -6  ?   ?   ?   B . n 
B 1 16  PRO 16  -5  ?   ?   ?   B . n 
B 1 17  ARG 17  -4  ?   ?   ?   B . n 
B 1 18  GLY 18  -3  ?   ?   ?   B . n 
B 1 19  SER 19  -2  ?   ?   ?   B . n 
B 1 20  HIS 20  -1  ?   ?   ?   B . n 
B 1 21  MET 21  0   ?   ?   ?   B . n 
B 1 22  LYS 22  1   1   LYS LYS B . n 
B 1 23  LYS 23  2   2   LYS LYS B . n 
B 1 24  PHE 24  3   3   PHE PHE B . n 
B 1 25  ASP 25  4   4   ASP ASP B . n 
B 1 26  PHE 26  5   5   PHE PHE B . n 
B 1 27  ILE 27  6   6   ILE ILE B . n 
B 1 28  ILE 28  7   7   ILE ILE B . n 
B 1 29  VAL 29  8   8   VAL VAL B . n 
B 1 30  GLY 30  9   9   GLY GLY B . n 
B 1 31  ALA 31  10  10  ALA ALA B . n 
B 1 32  GLY 32  11  11  GLY GLY B . n 
B 1 33  THR 33  12  12  THR THR B . n 
B 1 34  ALA 34  13  13  ALA ALA B . n 
B 1 35  GLY 35  14  14  GLY GLY B . n 
B 1 36  PRO 36  15  15  PRO PRO B . n 
B 1 37  VAL 37  16  16  VAL VAL B . n 
B 1 38  ILE 38  17  17  ILE ILE B . n 
B 1 39  ALA 39  18  18  ALA ALA B . n 
B 1 40  SER 40  19  19  SER SER B . n 
B 1 41  ARG 41  20  20  ARG ARG B . n 
B 1 42  LEU 42  21  21  LEU LEU B . n 
B 1 43  THR 43  22  22  THR THR B . n 
B 1 44  GLU 44  23  23  GLU GLU B . n 
B 1 45  LYS 45  24  24  LYS LYS B . n 
B 1 46  GLU 46  25  25  GLU GLU B . n 
B 1 47  HIS 47  26  26  HIS HIS B . n 
B 1 48  ILE 48  27  27  ILE ILE B . n 
B 1 49  ASN 49  28  28  ASN ASN B . n 
B 1 50  VAL 50  29  29  VAL VAL B . n 
B 1 51  LEU 51  30  30  LEU LEU B . n 
B 1 52  LEU 52  31  31  LEU LEU B . n 
B 1 53  LEU 53  32  32  LEU LEU B . n 
B 1 54  GLU 54  33  33  GLU GLU B . n 
B 1 55  ALA 55  34  34  ALA ALA B . n 
B 1 56  GLY 56  35  35  GLY GLY B . n 
B 1 57  GLY 57  36  36  GLY GLY B . n 
B 1 58  GLU 58  37  37  GLU GLU B . n 
B 1 59  ASN 59  38  38  ASN ASN B . n 
B 1 60  THR 60  39  39  THR THR B . n 
B 1 61  ASN 61  40  40  ASN ASN B . n 
B 1 62  GLU 62  41  41  GLU GLU B . n 
B 1 63  LEU 63  42  42  LEU LEU B . n 
B 1 64  SER 64  43  43  SER SER B . n 
B 1 65  ARG 65  44  44  ARG ARG B . n 
B 1 66  ILE 66  45  45  ILE ILE B . n 
B 1 67  PRO 67  46  46  PRO PRO B . n 
B 1 68  GLY 68  47  47  GLY GLY B . n 
B 1 69  ALA 69  48  48  ALA ALA B . n 
B 1 70  PHE 70  49  49  PHE PHE B . n 
B 1 71  PHE 71  50  50  PHE PHE B . n 
B 1 72  LYS 72  51  51  LYS LYS B . n 
B 1 73  VAL 73  52  52  VAL VAL B . n 
B 1 74  LEU 74  53  53  LEU LEU B . n 
B 1 75  GLY 75  54  54  GLY GLY B . n 
B 1 76  THR 76  55  55  THR THR B . n 
B 1 77  ASP 77  56  56  ASP ASP B . n 
B 1 78  TYR 78  57  57  TYR TYR B . n 
B 1 79  ASP 79  58  58  ASP ASP B . n 
B 1 80  TRP 80  59  59  TRP TRP B . n 
B 1 81  THR 81  60  60  THR THR B . n 
B 1 82  TYR 82  61  61  TYR TYR B . n 
B 1 83  SER 83  62  62  SER SER B . n 
B 1 84  SER 84  63  63  SER SER B . n 
B 1 85  VAL 85  64  64  VAL VAL B . n 
B 1 86  GLU 86  65  65  GLU GLU B . n 
B 1 87  GLN 87  66  66  GLN GLN B . n 
B 1 88  THR 88  67  67  THR THR B . n 
B 1 89  GLY 89  68  68  GLY GLY B . n 
B 1 90  LEU 90  69  69  LEU LEU B . n 
B 1 91  ASN 91  70  70  ASN ASN B . n 
B 1 92  ASN 92  71  71  ASN ASN B . n 
B 1 93  ARG 93  72  72  ARG ARG B . n 
B 1 94  SER 94  73  73  SER SER B . n 
B 1 95  ILE 95  74  74  ILE ILE B . n 
B 1 96  TYR 96  75  75  TYR TYR B . n 
B 1 97  SER 97  76  76  SER SER B . n 
B 1 98  PRO 98  77  77  PRO PRO B . n 
B 1 99  SER 99  78  78  SER SER B . n 
B 1 100 GLY 100 79  79  GLY GLY B . n 
B 1 101 LYS 101 80  80  LYS LYS B . n 
B 1 102 VAL 102 81  81  VAL VAL B . n 
B 1 103 VAL 103 82  82  VAL VAL B . n 
B 1 104 GLY 104 83  83  GLY GLY B . n 
B 1 105 GLY 105 84  84  GLY GLY B . n 
B 1 106 SER 106 85  85  SER SER B . n 
B 1 107 SER 107 86  86  SER SER B . n 
B 1 108 ALA 108 87  87  ALA ALA B . n 
B 1 109 ILE 109 88  88  ILE ILE B . n 
B 1 110 ASN 110 89  89  ASN ASN B . n 
B 1 111 VAL 111 90  90  VAL VAL B . n 
B 1 112 GLY 112 91  91  GLY GLY B . n 
B 1 113 VAL 113 92  92  VAL VAL B . n 
B 1 114 TRP 114 93  93  TRP TRP B . n 
B 1 115 VAL 115 94  94  VAL VAL B . n 
B 1 116 ARG 116 95  95  ARG ARG B . n 
B 1 117 GLY 117 96  96  GLY GLY B . n 
B 1 118 THR 118 97  97  THR THR B . n 
B 1 119 LYS 119 98  98  LYS LYS B . n 
B 1 120 GLU 120 99  99  GLU GLU B . n 
B 1 121 ASP 121 100 100 ASP ASP B . n 
B 1 122 TYR 122 101 101 TYR TYR B . n 
B 1 123 ASP 123 102 102 ASP ASP B . n 
B 1 124 SER 124 103 103 SER SER B . n 
B 1 125 TRP 125 104 104 TRP TRP B . n 
B 1 126 GLU 126 105 105 GLU GLU B . n 
B 1 127 ALA 127 106 106 ALA ALA B . n 
B 1 128 GLN 128 107 107 GLN GLN B . n 
B 1 129 GLY 129 108 108 GLY GLY B . n 
B 1 130 ALA 130 109 109 ALA ALA B . n 
B 1 131 LYS 131 110 110 LYS LYS B . n 
B 1 132 GLY 132 111 111 GLY GLY B . n 
B 1 133 TRP 133 112 112 TRP TRP B . n 
B 1 134 ASN 134 113 113 ASN ASN B . n 
B 1 135 PHE 135 114 114 PHE PHE B . n 
B 1 136 SER 136 115 115 SER SER B . n 
B 1 137 LYS 137 116 116 LYS LYS B . n 
B 1 138 ALA 138 117 117 ALA ALA B . n 
B 1 139 LEU 139 118 118 LEU LEU B . n 
B 1 140 GLU 140 119 119 GLU GLU B . n 
B 1 141 MET 141 120 120 MET MET B . n 
B 1 142 PHE 142 121 121 PHE PHE B . n 
B 1 143 GLN 143 122 122 GLN GLN B . n 
B 1 144 LYS 144 123 123 LYS LYS B . n 
B 1 145 ILE 145 124 124 ILE ILE B . n 
B 1 146 GLU 146 125 125 GLU GLU B . n 
B 1 147 GLN 147 126 126 GLN GLN B . n 
B 1 148 THR 148 127 127 THR THR B . n 
B 1 149 ASN 149 128 128 ASN ASN B . n 
B 1 150 LEU 150 129 129 LEU LEU B . n 
B 1 151 GLY 151 130 130 GLY GLY B . n 
B 1 152 PRO 152 131 131 PRO PRO B . n 
B 1 153 SER 153 132 132 SER SER B . n 
B 1 154 LYS 154 133 133 LYS LYS B . n 
B 1 155 TYR 155 134 134 TYR TYR B . n 
B 1 156 HIS 156 135 135 HIS HIS B . n 
B 1 157 GLY 157 136 136 GLY GLY B . n 
B 1 158 ASP 158 137 137 ASP ASP B . n 
B 1 159 LYS 159 138 138 LYS LYS B . n 
B 1 160 GLY 160 139 139 GLY GLY B . n 
B 1 161 LYS 161 140 140 LYS LYS B . n 
B 1 162 VAL 162 141 141 VAL VAL B . n 
B 1 163 LYS 163 142 142 LYS LYS B . n 
B 1 164 LEU 164 143 143 LEU LEU B . n 
B 1 165 THR 165 144 144 THR THR B . n 
B 1 166 ASP 166 145 145 ASP ASP B . n 
B 1 167 SER 167 146 146 SER SER B . n 
B 1 168 SER 168 147 147 SER SER B . n 
B 1 169 TYR 169 148 148 TYR TYR B . n 
B 1 170 PRO 170 149 149 PRO PRO B . n 
B 1 171 THR 171 150 150 THR THR B . n 
B 1 172 PRO 172 151 151 PRO PRO B . n 
B 1 173 PHE 173 152 152 PHE PHE B . n 
B 1 174 VAL 174 153 153 VAL VAL B . n 
B 1 175 HIS 175 154 154 HIS HIS B . n 
B 1 176 THR 176 155 155 THR THR B . n 
B 1 177 LEU 177 156 156 LEU LEU B . n 
B 1 178 LEU 178 157 157 LEU LEU B . n 
B 1 179 ASN 179 158 158 ASN ASN B . n 
B 1 180 GLY 180 159 159 GLY GLY B . n 
B 1 181 PHE 181 160 160 PHE PHE B . n 
B 1 182 LYS 182 161 161 LYS LYS B . n 
B 1 183 GLU 183 162 162 GLU GLU B . n 
B 1 184 ALA 184 163 163 ALA ALA B . n 
B 1 185 GLY 185 164 164 GLY GLY B . n 
B 1 186 PHE 186 165 165 PHE PHE B . n 
B 1 187 GLY 187 166 166 GLY GLY B . n 
B 1 188 GLU 188 167 167 GLU GLU B . n 
B 1 189 ILE 189 168 168 ILE ILE B . n 
B 1 190 GLY 190 169 169 GLY GLY B . n 
B 1 191 ASP 191 170 170 ASP ASP B . n 
B 1 192 TYR 192 171 171 TYR TYR B . n 
B 1 193 ALA 193 172 172 ALA ALA B . n 
B 1 194 GLY 194 173 173 GLY GLY B . n 
B 1 195 GLU 195 174 174 GLU GLU B . n 
B 1 196 ASN 196 175 175 ASN ASN B . n 
B 1 197 PRO 197 176 176 PRO PRO B . n 
B 1 198 TYR 198 177 177 TYR TYR B . n 
B 1 199 SER 199 178 178 SER SER B . n 
B 1 200 ILE 200 179 179 ILE ILE B . n 
B 1 201 ASP 201 180 180 ASP ASP B . n 
B 1 202 ILE 202 181 181 ILE ILE B . n 
B 1 203 MET 203 182 182 MET MET B . n 
B 1 204 GLN 204 183 183 GLN GLN B . n 
B 1 205 LYS 205 184 184 LYS LYS B . n 
B 1 206 ILE 206 185 185 ILE ILE B . n 
B 1 207 TYR 207 186 186 TYR TYR B . n 
B 1 208 GLU 208 187 187 GLU GLU B . n 
B 1 209 ASN 209 188 188 ASN ASN B . n 
B 1 210 ASN 210 189 189 ASN ASN B . n 
B 1 211 THR 211 190 190 THR THR B . n 
B 1 212 ARG 212 191 191 ARG ARG B . n 
B 1 213 ARG 213 192 192 ARG ARG B . n 
B 1 214 THR 214 193 193 THR THR B . n 
B 1 215 PRO 215 194 194 PRO PRO B . n 
B 1 216 ALA 216 195 195 ALA ALA B . n 
B 1 217 ASP 217 196 196 ASP ASP B . n 
B 1 218 SER 218 197 197 SER SER B . n 
B 1 219 TYR 219 198 198 TYR TYR B . n 
B 1 220 LEU 220 199 199 LEU LEU B . n 
B 1 221 THR 221 200 200 THR THR B . n 
B 1 222 GLU 222 201 201 GLU GLU B . n 
B 1 223 ASP 223 202 202 ASP ASP B . n 
B 1 224 VAL 224 203 203 VAL VAL B . n 
B 1 225 ARG 225 204 204 ARG ARG B . n 
B 1 226 ALA 226 205 205 ALA ALA B . n 
B 1 227 ARG 227 206 206 ARG ARG B . n 
B 1 228 GLU 228 207 207 GLU GLU B . n 
B 1 229 ASN 229 208 208 ASN ASN B . n 
B 1 230 LEU 230 209 209 LEU LEU B . n 
B 1 231 THR 231 210 210 THR THR B . n 
B 1 232 ILE 232 211 211 ILE ILE B . n 
B 1 233 ILE 233 212 212 ILE ILE B . n 
B 1 234 THR 234 213 213 THR THR B . n 
B 1 235 HIS 235 214 214 HIS HIS B . n 
B 1 236 ALA 236 215 215 ALA ALA B . n 
B 1 237 PHE 237 216 216 PHE PHE B . n 
B 1 238 VAL 238 217 217 VAL VAL B . n 
B 1 239 ARG 239 218 218 ARG ARG B . n 
B 1 240 LYS 240 219 219 LYS LYS B . n 
B 1 241 VAL 241 220 220 VAL VAL B . n 
B 1 242 LEU 242 221 221 LEU LEU B . n 
B 1 243 PHE 243 222 222 PHE PHE B . n 
B 1 244 GLU 244 223 223 GLU GLU B . n 
B 1 245 GLY 245 224 224 GLY GLY B . n 
B 1 246 THR 246 225 225 THR THR B . n 
B 1 247 LYS 247 226 226 LYS LYS B . n 
B 1 248 ALA 248 227 227 ALA ALA B . n 
B 1 249 ILE 249 228 228 ILE ILE B . n 
B 1 250 GLY 250 229 229 GLY GLY B . n 
B 1 251 VAL 251 230 230 VAL VAL B . n 
B 1 252 GLU 252 231 231 GLU GLU B . n 
B 1 253 VAL 253 232 232 VAL VAL B . n 
B 1 254 GLU 254 233 233 GLU GLU B . n 
B 1 255 ILE 255 234 234 ILE ILE B . n 
B 1 256 ASP 256 235 235 ASP ASP B . n 
B 1 257 GLY 257 236 236 GLY GLY B . n 
B 1 258 GLN 258 237 237 GLN GLN B . n 
B 1 259 ILE 259 238 238 ILE ILE B . n 
B 1 260 GLN 260 239 239 GLN GLN B . n 
B 1 261 ASN 261 240 240 ASN ASN B . n 
B 1 262 MET 262 241 241 MET MET B . n 
B 1 263 TYR 263 242 242 TYR TYR B . n 
B 1 264 ALA 264 243 243 ALA ALA B . n 
B 1 265 SER 265 244 244 SER SER B . n 
B 1 266 LYS 266 245 245 LYS LYS B . n 
B 1 267 GLU 267 246 246 GLU GLU B . n 
B 1 268 ILE 268 247 247 ILE ILE B . n 
B 1 269 ILE 269 248 248 ILE ILE B . n 
B 1 270 LEU 270 249 249 LEU LEU B . n 
B 1 271 SER 271 250 250 SER SER B . n 
B 1 272 ALA 272 251 251 ALA ALA B . n 
B 1 273 GLY 273 252 252 GLY GLY B . n 
B 1 274 THR 274 253 253 THR THR B . n 
B 1 275 PHE 275 254 254 PHE PHE B . n 
B 1 276 ASN 276 255 255 ASN ASN B . n 
B 1 277 THR 277 256 256 THR THR B . n 
B 1 278 PRO 278 257 257 PRO PRO B . n 
B 1 279 LYS 279 258 258 LYS LYS B . n 
B 1 280 LEU 280 259 259 LEU LEU B . n 
B 1 281 LEU 281 260 260 LEU LEU B . n 
B 1 282 LYS 282 261 261 LYS LYS B . n 
B 1 283 LEU 283 262 262 LEU LEU B . n 
B 1 284 SER 284 263 263 SER SER B . n 
B 1 285 GLY 285 264 264 GLY GLY B . n 
B 1 286 VAL 286 265 265 VAL VAL B . n 
B 1 287 GLY 287 266 266 GLY GLY B . n 
B 1 288 PRO 288 267 267 PRO PRO B . n 
B 1 289 ARG 289 268 268 ARG ARG B . n 
B 1 290 GLU 290 269 269 GLU GLU B . n 
B 1 291 GLU 291 270 270 GLU GLU B . n 
B 1 292 LEU 292 271 271 LEU LEU B . n 
B 1 293 GLU 293 272 272 GLU GLU B . n 
B 1 294 LYS 294 273 273 LYS LYS B . n 
B 1 295 PHE 295 274 274 PHE PHE B . n 
B 1 296 GLY 296 275 275 GLY GLY B . n 
B 1 297 ILE 297 276 276 ILE ILE B . n 
B 1 298 PRO 298 277 277 PRO PRO B . n 
B 1 299 VAL 299 278 278 VAL VAL B . n 
B 1 300 ILE 300 279 279 ILE ILE B . n 
B 1 301 ALA 301 280 280 ALA ALA B . n 
B 1 302 ASN 302 281 281 ASN ASN B . n 
B 1 303 VAL 303 282 282 VAL VAL B . n 
B 1 304 PRO 304 283 283 PRO PRO B . n 
B 1 305 GLY 305 284 284 GLY GLY B . n 
B 1 306 VAL 306 285 285 VAL VAL B . n 
B 1 307 GLY 307 286 286 GLY GLY B . n 
B 1 308 GLU 308 287 287 GLU GLU B . n 
B 1 309 ASN 309 288 288 ASN ASN B . n 
B 1 310 LEU 310 289 289 LEU LEU B . n 
B 1 311 ASN 311 290 290 ASN ASN B . n 
B 1 312 ASP 312 291 291 ASP ASP B . n 
B 1 313 HIS 313 292 292 HIS HIS B . n 
B 1 314 LEU 314 293 293 LEU LEU B . n 
B 1 315 MET 315 294 294 MET MET B . n 
B 1 316 PHE 316 295 295 PHE PHE B . n 
B 1 317 THR 317 296 296 THR THR B . n 
B 1 318 LEU 318 297 297 LEU LEU B . n 
B 1 319 LYS 319 298 298 LYS LYS B . n 
B 1 320 PHE 320 299 299 PHE PHE B . n 
B 1 321 VAL 321 300 300 VAL VAL B . n 
B 1 322 SER 322 301 301 SER SER B . n 
B 1 323 GLU 323 302 302 GLU GLU B . n 
B 1 324 LYS 324 303 303 LYS LYS B . n 
B 1 325 ASN 325 304 304 ASN ASN B . n 
B 1 326 ILE 326 305 305 ILE ILE B . n 
B 1 327 GLU 327 306 306 GLU GLU B . n 
B 1 328 ASP 328 307 307 ASP ASP B . n 
B 1 329 SER 329 308 308 SER SER B . n 
B 1 330 ILE 330 309 309 ILE ILE B . n 
B 1 331 PHE 331 310 310 PHE PHE B . n 
B 1 332 ASN 332 311 311 ASN ASN B . n 
B 1 333 PRO 333 312 312 PRO PRO B . n 
B 1 334 LEU 334 313 313 LEU LEU B . n 
B 1 335 SER 335 314 314 SER SER B . n 
B 1 336 ASP 336 315 315 ASP ASP B . n 
B 1 337 GLU 337 316 316 GLU GLU B . n 
B 1 338 ALA 338 317 317 ALA ALA B . n 
B 1 339 ILE 339 318 318 ILE ILE B . n 
B 1 340 ASP 340 319 319 ASP ASP B . n 
B 1 341 GLN 341 320 320 GLN GLN B . n 
B 1 342 TRP 342 321 321 TRP TRP B . n 
B 1 343 TYR 343 322 322 TYR TYR B . n 
B 1 344 LYS 344 323 323 LYS LYS B . n 
B 1 345 ASN 345 324 324 ASN ASN B . n 
B 1 346 LYS 346 325 325 LYS LYS B . n 
B 1 347 THR 347 326 326 THR THR B . n 
B 1 348 GLY 348 327 327 GLY GLY B . n 
B 1 349 PRO 349 328 328 PRO PRO B . n 
B 1 350 SER 350 329 329 SER SER B . n 
B 1 351 SER 351 330 330 SER SER B . n 
B 1 352 TYR 352 331 331 TYR TYR B . n 
B 1 353 TYR 353 332 332 TYR TYR B . n 
B 1 354 PRO 354 333 333 PRO PRO B . n 
B 1 355 GLY 355 334 334 GLY GLY B . n 
B 1 356 VAL 356 335 335 VAL VAL B . n 
B 1 357 ALA 357 336 336 ALA ALA B . n 
B 1 358 SER 358 337 337 SER SER B . n 
B 1 359 GLY 359 338 338 GLY GLY B . n 
B 1 360 PHE 360 339 339 PHE PHE B . n 
B 1 361 VAL 361 340 340 VAL VAL B . n 
B 1 362 SER 362 341 341 SER SER B . n 
B 1 363 SER 363 342 342 SER SER B . n 
B 1 364 ASP 364 343 343 ASP ASP B . n 
B 1 365 GLY 365 344 344 GLY GLY B . n 
B 1 366 THR 366 345 345 THR THR B . n 
B 1 367 LYS 367 346 346 LYS LYS B . n 
B 1 368 THR 368 347 347 THR THR B . n 
B 1 369 GLY 369 348 348 GLY GLY B . n 
B 1 370 ALA 370 349 349 ALA ALA B . n 
B 1 371 ASP 371 350 350 ASP ASP B . n 
B 1 372 PHE 372 351 351 PHE PHE B . n 
B 1 373 GLU 373 352 352 GLU GLU B . n 
B 1 374 LEU 374 353 353 LEU LEU B . n 
B 1 375 ILE 375 354 354 ILE ILE B . n 
B 1 376 PHE 376 355 355 PHE PHE B . n 
B 1 377 THR 377 356 356 THR THR B . n 
B 1 378 TYR 378 357 357 TYR TYR B . n 
B 1 379 THR 379 358 358 THR THR B . n 
B 1 380 HIS 380 359 359 HIS HIS B . n 
B 1 381 GLY 381 360 360 GLY GLY B . n 
B 1 382 ALA 382 361 361 ALA ALA B . n 
B 1 383 ASP 383 362 362 ASP ASP B . n 
B 1 384 GLY 384 363 363 GLY GLY B . n 
B 1 385 THR 385 364 364 THR THR B . n 
B 1 386 GLU 386 365 365 GLU GLU B . n 
B 1 387 LYS 387 366 366 LYS LYS B . n 
B 1 388 GLU 388 367 367 GLU GLU B . n 
B 1 389 PHE 389 368 368 PHE PHE B . n 
B 1 390 ALA 390 369 369 ALA ALA B . n 
B 1 391 ASN 391 370 370 ASN ASN B . n 
B 1 392 ILE 392 371 371 ILE ILE B . n 
B 1 393 GLU 393 372 372 GLU GLU B . n 
B 1 394 ASP 394 373 373 ASP ASP B . n 
B 1 395 ILE 395 374 374 ILE ILE B . n 
B 1 396 GLN 396 375 375 GLN GLN B . n 
B 1 397 ALA 397 376 376 ALA ALA B . n 
B 1 398 GLN 398 377 377 GLN GLN B . n 
B 1 399 SER 399 378 378 SER SER B . n 
B 1 400 GLY 400 379 379 GLY GLY B . n 
B 1 401 TYR 401 380 380 TYR TYR B . n 
B 1 402 SER 402 381 381 SER SER B . n 
B 1 403 VAL 403 382 382 VAL VAL B . n 
B 1 404 THR 404 383 383 THR THR B . n 
B 1 405 VAL 405 384 384 VAL VAL B . n 
B 1 406 ILE 406 385 385 ILE ILE B . n 
B 1 407 LEU 407 386 386 LEU LEU B . n 
B 1 408 LEU 408 387 387 LEU LEU B . n 
B 1 409 GLN 409 388 388 GLN GLN B . n 
B 1 410 PRO 410 389 389 PRO PRO B . n 
B 1 411 LYS 411 390 390 LYS LYS B . n 
B 1 412 SER 412 391 391 SER SER B . n 
B 1 413 ARG 413 392 392 ARG ARG B . n 
B 1 414 GLY 414 393 393 GLY GLY B . n 
B 1 415 GLN 415 394 394 GLN GLN B . n 
B 1 416 LEU 416 395 395 LEU LEU B . n 
B 1 417 LEU 417 396 396 LEU LEU B . n 
B 1 418 LEU 418 397 397 LEU LEU B . n 
B 1 419 ALA 419 398 398 ALA ALA B . n 
B 1 420 SER 420 399 399 SER SER B . n 
B 1 421 THR 421 400 400 THR THR B . n 
B 1 422 ASN 422 401 401 ASN ASN B . n 
B 1 423 PRO 423 402 402 PRO PRO B . n 
B 1 424 TYR 424 403 403 TYR TYR B . n 
B 1 425 ASP 425 404 404 ASP ASP B . n 
B 1 426 ALA 426 405 405 ALA ALA B . n 
B 1 427 PRO 427 406 406 PRO PRO B . n 
B 1 428 LEU 428 407 407 LEU LEU B . n 
B 1 429 ILE 429 408 408 ILE ILE B . n 
B 1 430 ASN 430 409 409 ASN ASN B . n 
B 1 431 PRO 431 410 410 PRO PRO B . n 
B 1 432 ARG 432 411 411 ARG ARG B . n 
B 1 433 TYR 433 412 412 TYR TYR B . n 
B 1 434 PHE 434 413 413 PHE PHE B . n 
B 1 435 SER 435 414 414 SER SER B . n 
B 1 436 ASP 436 415 415 ASP ASP B . n 
B 1 437 SER 437 416 416 SER SER B . n 
B 1 438 SER 438 417 417 SER SER B . n 
B 1 439 ASP 439 418 418 ASP ASP B . n 
B 1 440 MET 440 419 419 MET MET B . n 
B 1 441 GLU 441 420 420 GLU GLU B . n 
B 1 442 ARG 442 421 421 ARG ARG B . n 
B 1 443 PHE 443 422 422 PHE PHE B . n 
B 1 444 ILE 444 423 423 ILE ILE B . n 
B 1 445 LYS 445 424 424 LYS LYS B . n 
B 1 446 GLY 446 425 425 GLY GLY B . n 
B 1 447 VAL 447 426 426 VAL VAL B . n 
B 1 448 ARG 448 427 427 ARG ARG B . n 
B 1 449 TYR 449 428 428 TYR TYR B . n 
B 1 450 THR 450 429 429 THR THR B . n 
B 1 451 GLN 451 430 430 GLN GLN B . n 
B 1 452 LYS 452 431 431 LYS LYS B . n 
B 1 453 ILE 453 432 432 ILE ILE B . n 
B 1 454 THR 454 433 433 THR THR B . n 
B 1 455 LYS 455 434 434 LYS LYS B . n 
B 1 456 THR 456 435 435 THR THR B . n 
B 1 457 GLU 457 436 436 GLU GLU B . n 
B 1 458 SER 458 437 437 SER SER B . n 
B 1 459 LEU 459 438 438 LEU LEU B . n 
B 1 460 GLU 460 439 439 GLU GLU B . n 
B 1 461 PRO 461 440 440 PRO PRO B . n 
B 1 462 TYR 462 441 441 TYR TYR B . n 
B 1 463 THR 463 442 442 THR THR B . n 
B 1 464 TYR 464 443 443 TYR TYR B . n 
B 1 465 LEU 465 444 444 LEU LEU B . n 
B 1 466 ALA 466 445 445 ALA ALA B . n 
B 1 467 HIS 467 446 446 HIS HIS B . n 
B 1 468 PRO 468 447 447 PRO PRO B . n 
B 1 469 ALA 469 448 448 ALA ALA B . n 
B 1 470 LEU 470 449 449 LEU LEU B . n 
B 1 471 ASP 471 450 450 ASP ASP B . n 
B 1 472 ALA 472 451 451 ALA ALA B . n 
B 1 473 THR 473 452 452 THR THR B . n 
B 1 474 ASP 474 453 453 ASP ASP B . n 
B 1 475 GLU 475 454 454 GLU GLU B . n 
B 1 476 ILE 476 455 455 ILE ILE B . n 
B 1 477 ILE 477 456 456 ILE ILE B . n 
B 1 478 GLU 478 457 457 GLU GLU B . n 
B 1 479 SER 479 458 458 SER SER B . n 
B 1 480 LEU 480 459 459 LEU LEU B . n 
B 1 481 ILE 481 460 460 ILE ILE B . n 
B 1 482 ARG 482 461 461 ARG ARG B . n 
B 1 483 ASN 483 462 462 ASN ASN B . n 
B 1 484 GLU 484 463 463 GLU GLU B . n 
B 1 485 ALA 485 464 464 ALA ALA B . n 
B 1 486 SER 486 465 465 SER SER B . n 
B 1 487 THR 487 466 466 THR THR B . n 
B 1 488 VAL 488 467 467 VAL VAL B . n 
B 1 489 PHE 489 468 468 PHE PHE B . n 
B 1 490 HIS 490 469 469 HIS HIS B . n 
B 1 491 PRO 491 470 470 PRO PRO B . n 
B 1 492 VAL 492 471 471 VAL VAL B . n 
B 1 493 GLY 493 472 472 GLY GLY B . n 
B 1 494 THR 494 473 473 THR THR B . n 
B 1 495 ALA 495 474 474 ALA ALA B . n 
B 1 496 ARG 496 475 475 ARG ARG B . n 
B 1 497 MET 497 476 476 MET MET B . n 
B 1 498 GLY 498 477 477 GLY GLY B . n 
B 1 499 ASP 499 478 478 ASP ASP B . n 
B 1 500 VAL 500 479 479 VAL VAL B . n 
B 1 501 GLU 501 480 480 GLU GLU B . n 
B 1 502 ASN 502 481 481 ASN ASN B . n 
B 1 503 ASP 503 482 482 ASP ASP B . n 
B 1 504 SER 504 483 483 SER SER B . n 
B 1 505 LEU 505 484 484 LEU LEU B . n 
B 1 506 ALA 506 485 485 ALA ALA B . n 
B 1 507 VAL 507 486 486 VAL VAL B . n 
B 1 508 VAL 508 487 487 VAL VAL B . n 
B 1 509 ASP 509 488 488 ASP ASP B . n 
B 1 510 SER 510 489 489 SER SER B . n 
B 1 511 SER 511 490 490 SER SER B . n 
B 1 512 LEU 512 491 491 LEU LEU B . n 
B 1 513 LYS 513 492 492 LYS LYS B . n 
B 1 514 VAL 514 493 493 VAL VAL B . n 
B 1 515 ARG 515 494 494 ARG ARG B . n 
B 1 516 GLY 516 495 495 GLY GLY B . n 
B 1 517 ILE 517 496 496 ILE ILE B . n 
B 1 518 GLN 518 497 497 GLN GLN B . n 
B 1 519 GLY 519 498 498 GLY GLY B . n 
B 1 520 LEU 520 499 499 LEU LEU B . n 
B 1 521 ARG 521 500 500 ARG ARG B . n 
B 1 522 VAL 522 501 501 VAL VAL B . n 
B 1 523 ALA 523 502 502 ALA ALA B . n 
B 1 524 ASP 524 503 503 ASP ASP B . n 
B 1 525 ALA 525 504 504 ALA ALA B . n 
B 1 526 SER 526 505 505 SER SER B . n 
B 1 527 ILE 527 506 506 ILE ILE B . n 
B 1 528 ILE 528 507 507 ILE ILE B . n 
B 1 529 PRO 529 508 508 PRO PRO B . n 
B 1 530 ALA 530 509 509 ALA ALA B . n 
B 1 531 VAL 531 510 510 VAL VAL B . n 
B 1 532 ASN 532 511 511 ASN ASN B . n 
B 1 533 ARG 533 512 512 ARG ARG B . n 
B 1 534 GLY 534 513 513 GLY GLY B . n 
B 1 535 HIS 535 514 514 HIS HIS B . n 
B 1 536 THR 536 515 515 THR THR B . n 
B 1 537 MET 537 516 516 MET MET B . n 
B 1 538 ALA 538 517 517 ALA ALA B . n 
B 1 539 PRO 539 518 518 PRO PRO B . n 
B 1 540 VAL 540 519 519 VAL VAL B . n 
B 1 541 VAL 541 520 520 VAL VAL B . n 
B 1 542 TYR 542 521 521 TYR TYR B . n 
B 1 543 VAL 543 522 522 VAL VAL B . n 
B 1 544 GLY 544 523 523 GLY GLY B . n 
B 1 545 GLU 545 524 524 GLU GLU B . n 
B 1 546 MET 546 525 525 MET MET B . n 
B 1 547 ALA 547 526 526 ALA ALA B . n 
B 1 548 SER 548 527 527 SER SER B . n 
B 1 549 GLU 549 528 528 GLU GLU B . n 
B 1 550 ILE 550 529 529 ILE ILE B . n 
B 1 551 ILE 551 530 530 ILE ILE B . n 
B 1 552 ILE 552 531 531 ILE ILE B . n 
B 1 553 ASN 553 532 532 ASN ASN B . n 
B 1 554 ASP 554 533 533 ASP ASP B . n 
B 1 555 ASN 555 534 534 ASN ASN B . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 FAD ? ? FAD ? ? 'SUBJECT OF INVESTIGATION' ? 
2 HEZ ? ? HEZ ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 1BO 1   601  603 1BO 1BO A . 
D 2 1BO 1   602  604 1BO 1BO A . 
E 3 FAD 1   603  601 FAD FAD A . 
F 4 HEZ 1   604  602 HEZ HEZ A . 
G 3 FAD 1   601  601 FAD FAD B . 
H 4 HEZ 1   602  602 HEZ HEZ B . 
I 5 HOH 1   701  480 HOH HOH A . 
I 5 HOH 2   702  437 HOH HOH A . 
I 5 HOH 3   703  359 HOH HOH A . 
I 5 HOH 4   704  168 HOH HOH A . 
I 5 HOH 5   705  222 HOH HOH A . 
I 5 HOH 6   706  587 HOH HOH A . 
I 5 HOH 7   707  33  HOH HOH A . 
I 5 HOH 8   708  427 HOH HOH A . 
I 5 HOH 9   709  57  HOH HOH A . 
I 5 HOH 10  710  573 HOH HOH A . 
I 5 HOH 11  711  263 HOH HOH A . 
I 5 HOH 12  712  472 HOH HOH A . 
I 5 HOH 13  713  36  HOH HOH A . 
I 5 HOH 14  714  205 HOH HOH A . 
I 5 HOH 15  715  470 HOH HOH A . 
I 5 HOH 16  716  300 HOH HOH A . 
I 5 HOH 17  717  217 HOH HOH A . 
I 5 HOH 18  718  247 HOH HOH A . 
I 5 HOH 19  719  572 HOH HOH A . 
I 5 HOH 20  720  220 HOH HOH A . 
I 5 HOH 21  721  591 HOH HOH A . 
I 5 HOH 22  722  75  HOH HOH A . 
I 5 HOH 23  723  227 HOH HOH A . 
I 5 HOH 24  724  76  HOH HOH A . 
I 5 HOH 25  725  620 HOH HOH A . 
I 5 HOH 26  726  351 HOH HOH A . 
I 5 HOH 27  727  735 HOH HOH A . 
I 5 HOH 28  728  589 HOH HOH A . 
I 5 HOH 29  729  517 HOH HOH A . 
I 5 HOH 30  730  488 HOH HOH A . 
I 5 HOH 31  731  726 HOH HOH A . 
I 5 HOH 32  732  315 HOH HOH A . 
I 5 HOH 33  733  478 HOH HOH A . 
I 5 HOH 34  734  104 HOH HOH A . 
I 5 HOH 35  735  637 HOH HOH A . 
I 5 HOH 36  736  733 HOH HOH A . 
I 5 HOH 37  737  484 HOH HOH A . 
I 5 HOH 38  738  350 HOH HOH A . 
I 5 HOH 39  739  291 HOH HOH A . 
I 5 HOH 40  740  448 HOH HOH A . 
I 5 HOH 41  741  599 HOH HOH A . 
I 5 HOH 42  742  541 HOH HOH A . 
I 5 HOH 43  743  580 HOH HOH A . 
I 5 HOH 44  744  327 HOH HOH A . 
I 5 HOH 45  745  182 HOH HOH A . 
I 5 HOH 46  746  152 HOH HOH A . 
I 5 HOH 47  747  538 HOH HOH A . 
I 5 HOH 48  748  292 HOH HOH A . 
I 5 HOH 49  749  284 HOH HOH A . 
I 5 HOH 50  750  181 HOH HOH A . 
I 5 HOH 51  751  64  HOH HOH A . 
I 5 HOH 52  752  62  HOH HOH A . 
I 5 HOH 53  753  625 HOH HOH A . 
I 5 HOH 54  754  521 HOH HOH A . 
I 5 HOH 55  755  467 HOH HOH A . 
I 5 HOH 56  756  206 HOH HOH A . 
I 5 HOH 57  757  34  HOH HOH A . 
I 5 HOH 58  758  724 HOH HOH A . 
I 5 HOH 59  759  614 HOH HOH A . 
I 5 HOH 60  760  674 HOH HOH A . 
I 5 HOH 61  761  685 HOH HOH A . 
I 5 HOH 62  762  569 HOH HOH A . 
I 5 HOH 63  763  153 HOH HOH A . 
I 5 HOH 64  764  283 HOH HOH A . 
I 5 HOH 65  765  530 HOH HOH A . 
I 5 HOH 66  766  19  HOH HOH A . 
I 5 HOH 67  767  481 HOH HOH A . 
I 5 HOH 68  768  53  HOH HOH A . 
I 5 HOH 69  769  13  HOH HOH A . 
I 5 HOH 70  770  196 HOH HOH A . 
I 5 HOH 71  771  252 HOH HOH A . 
I 5 HOH 72  772  692 HOH HOH A . 
I 5 HOH 73  773  344 HOH HOH A . 
I 5 HOH 74  774  100 HOH HOH A . 
I 5 HOH 75  775  37  HOH HOH A . 
I 5 HOH 76  776  710 HOH HOH A . 
I 5 HOH 77  777  443 HOH HOH A . 
I 5 HOH 78  778  691 HOH HOH A . 
I 5 HOH 79  779  290 HOH HOH A . 
I 5 HOH 80  780  623 HOH HOH A . 
I 5 HOH 81  781  26  HOH HOH A . 
I 5 HOH 82  782  656 HOH HOH A . 
I 5 HOH 83  783  334 HOH HOH A . 
I 5 HOH 84  784  438 HOH HOH A . 
I 5 HOH 85  785  23  HOH HOH A . 
I 5 HOH 86  786  51  HOH HOH A . 
I 5 HOH 87  787  542 HOH HOH A . 
I 5 HOH 88  788  61  HOH HOH A . 
I 5 HOH 89  789  574 HOH HOH A . 
I 5 HOH 90  790  203 HOH HOH A . 
I 5 HOH 91  791  651 HOH HOH A . 
I 5 HOH 92  792  583 HOH HOH A . 
I 5 HOH 93  793  445 HOH HOH A . 
I 5 HOH 94  794  709 HOH HOH A . 
I 5 HOH 95  795  451 HOH HOH A . 
I 5 HOH 96  796  208 HOH HOH A . 
I 5 HOH 97  797  8   HOH HOH A . 
I 5 HOH 98  798  32  HOH HOH A . 
I 5 HOH 99  799  239 HOH HOH A . 
I 5 HOH 100 800  441 HOH HOH A . 
I 5 HOH 101 801  630 HOH HOH A . 
I 5 HOH 102 802  198 HOH HOH A . 
I 5 HOH 103 803  178 HOH HOH A . 
I 5 HOH 104 804  20  HOH HOH A . 
I 5 HOH 105 805  308 HOH HOH A . 
I 5 HOH 106 806  514 HOH HOH A . 
I 5 HOH 107 807  601 HOH HOH A . 
I 5 HOH 108 808  105 HOH HOH A . 
I 5 HOH 109 809  176 HOH HOH A . 
I 5 HOH 110 810  456 HOH HOH A . 
I 5 HOH 111 811  548 HOH HOH A . 
I 5 HOH 112 812  255 HOH HOH A . 
I 5 HOH 113 813  411 HOH HOH A . 
I 5 HOH 114 814  627 HOH HOH A . 
I 5 HOH 115 815  453 HOH HOH A . 
I 5 HOH 116 816  177 HOH HOH A . 
I 5 HOH 117 817  4   HOH HOH A . 
I 5 HOH 118 818  641 HOH HOH A . 
I 5 HOH 119 819  562 HOH HOH A . 
I 5 HOH 120 820  455 HOH HOH A . 
I 5 HOH 121 821  99  HOH HOH A . 
I 5 HOH 122 822  159 HOH HOH A . 
I 5 HOH 123 823  6   HOH HOH A . 
I 5 HOH 124 824  270 HOH HOH A . 
I 5 HOH 125 825  202 HOH HOH A . 
I 5 HOH 126 826  465 HOH HOH A . 
I 5 HOH 127 827  98  HOH HOH A . 
I 5 HOH 128 828  87  HOH HOH A . 
I 5 HOH 129 829  681 HOH HOH A . 
I 5 HOH 130 830  439 HOH HOH A . 
I 5 HOH 131 831  513 HOH HOH A . 
I 5 HOH 132 832  44  HOH HOH A . 
I 5 HOH 133 833  195 HOH HOH A . 
I 5 HOH 134 834  14  HOH HOH A . 
I 5 HOH 135 835  137 HOH HOH A . 
I 5 HOH 136 836  638 HOH HOH A . 
I 5 HOH 137 837  108 HOH HOH A . 
I 5 HOH 138 838  332 HOH HOH A . 
I 5 HOH 139 839  577 HOH HOH A . 
I 5 HOH 140 840  615 HOH HOH A . 
I 5 HOH 141 841  146 HOH HOH A . 
I 5 HOH 142 842  686 HOH HOH A . 
I 5 HOH 143 843  243 HOH HOH A . 
I 5 HOH 144 844  2   HOH HOH A . 
I 5 HOH 145 845  442 HOH HOH A . 
I 5 HOH 146 846  376 HOH HOH A . 
I 5 HOH 147 847  139 HOH HOH A . 
I 5 HOH 148 848  110 HOH HOH A . 
I 5 HOH 149 849  260 HOH HOH A . 
I 5 HOH 150 850  708 HOH HOH A . 
I 5 HOH 151 851  552 HOH HOH A . 
I 5 HOH 152 852  511 HOH HOH A . 
I 5 HOH 153 853  714 HOH HOH A . 
I 5 HOH 154 854  536 HOH HOH A . 
I 5 HOH 155 855  275 HOH HOH A . 
I 5 HOH 156 856  477 HOH HOH A . 
I 5 HOH 157 857  512 HOH HOH A . 
I 5 HOH 158 858  118 HOH HOH A . 
I 5 HOH 159 859  358 HOH HOH A . 
I 5 HOH 160 860  74  HOH HOH A . 
I 5 HOH 161 861  123 HOH HOH A . 
I 5 HOH 162 862  47  HOH HOH A . 
I 5 HOH 163 863  571 HOH HOH A . 
I 5 HOH 164 864  38  HOH HOH A . 
I 5 HOH 165 865  221 HOH HOH A . 
I 5 HOH 166 866  593 HOH HOH A . 
I 5 HOH 167 867  661 HOH HOH A . 
I 5 HOH 168 868  163 HOH HOH A . 
I 5 HOH 169 869  559 HOH HOH A . 
I 5 HOH 170 870  237 HOH HOH A . 
I 5 HOH 171 871  486 HOH HOH A . 
I 5 HOH 172 872  30  HOH HOH A . 
I 5 HOH 173 873  42  HOH HOH A . 
I 5 HOH 174 874  556 HOH HOH A . 
I 5 HOH 175 875  131 HOH HOH A . 
I 5 HOH 176 876  654 HOH HOH A . 
I 5 HOH 177 877  594 HOH HOH A . 
I 5 HOH 178 878  95  HOH HOH A . 
I 5 HOH 179 879  154 HOH HOH A . 
I 5 HOH 180 880  254 HOH HOH A . 
I 5 HOH 181 881  595 HOH HOH A . 
I 5 HOH 182 882  204 HOH HOH A . 
I 5 HOH 183 883  588 HOH HOH A . 
I 5 HOH 184 884  232 HOH HOH A . 
I 5 HOH 185 885  435 HOH HOH A . 
I 5 HOH 186 886  17  HOH HOH A . 
I 5 HOH 187 887  331 HOH HOH A . 
I 5 HOH 188 888  602 HOH HOH A . 
I 5 HOH 189 889  109 HOH HOH A . 
I 5 HOH 190 890  428 HOH HOH A . 
I 5 HOH 191 891  499 HOH HOH A . 
I 5 HOH 192 892  662 HOH HOH A . 
I 5 HOH 193 893  504 HOH HOH A . 
I 5 HOH 194 894  21  HOH HOH A . 
I 5 HOH 195 895  40  HOH HOH A . 
I 5 HOH 196 896  150 HOH HOH A . 
I 5 HOH 197 897  419 HOH HOH A . 
I 5 HOH 198 898  645 HOH HOH A . 
I 5 HOH 199 899  683 HOH HOH A . 
I 5 HOH 200 900  717 HOH HOH A . 
I 5 HOH 201 901  728 HOH HOH A . 
I 5 HOH 202 902  112 HOH HOH A . 
I 5 HOH 203 903  240 HOH HOH A . 
I 5 HOH 204 904  267 HOH HOH A . 
I 5 HOH 205 905  223 HOH HOH A . 
I 5 HOH 206 906  608 HOH HOH A . 
I 5 HOH 207 907  86  HOH HOH A . 
I 5 HOH 208 908  401 HOH HOH A . 
I 5 HOH 209 909  378 HOH HOH A . 
I 5 HOH 210 910  565 HOH HOH A . 
I 5 HOH 211 911  145 HOH HOH A . 
I 5 HOH 212 912  725 HOH HOH A . 
I 5 HOH 213 913  70  HOH HOH A . 
I 5 HOH 214 914  219 HOH HOH A . 
I 5 HOH 215 915  450 HOH HOH A . 
I 5 HOH 216 916  460 HOH HOH A . 
I 5 HOH 217 917  721 HOH HOH A . 
I 5 HOH 218 918  597 HOH HOH A . 
I 5 HOH 219 919  73  HOH HOH A . 
I 5 HOH 220 920  487 HOH HOH A . 
I 5 HOH 221 921  136 HOH HOH A . 
I 5 HOH 222 922  79  HOH HOH A . 
I 5 HOH 223 923  657 HOH HOH A . 
I 5 HOH 224 924  483 HOH HOH A . 
I 5 HOH 225 925  158 HOH HOH A . 
I 5 HOH 226 926  604 HOH HOH A . 
I 5 HOH 227 927  466 HOH HOH A . 
I 5 HOH 228 928  647 HOH HOH A . 
I 5 HOH 229 929  257 HOH HOH A . 
I 5 HOH 230 930  55  HOH HOH A . 
I 5 HOH 231 931  9   HOH HOH A . 
I 5 HOH 232 932  457 HOH HOH A . 
I 5 HOH 233 933  268 HOH HOH A . 
I 5 HOH 234 934  459 HOH HOH A . 
I 5 HOH 235 935  557 HOH HOH A . 
I 5 HOH 236 936  56  HOH HOH A . 
I 5 HOH 237 937  200 HOH HOH A . 
I 5 HOH 238 938  293 HOH HOH A . 
I 5 HOH 239 939  449 HOH HOH A . 
I 5 HOH 240 940  234 HOH HOH A . 
I 5 HOH 241 941  29  HOH HOH A . 
I 5 HOH 242 942  622 HOH HOH A . 
I 5 HOH 243 943  404 HOH HOH A . 
I 5 HOH 244 944  644 HOH HOH A . 
I 5 HOH 245 945  407 HOH HOH A . 
I 5 HOH 246 946  365 HOH HOH A . 
I 5 HOH 247 947  353 HOH HOH A . 
I 5 HOH 248 948  652 HOH HOH A . 
I 5 HOH 249 949  440 HOH HOH A . 
I 5 HOH 250 950  180 HOH HOH A . 
I 5 HOH 251 951  157 HOH HOH A . 
I 5 HOH 252 952  296 HOH HOH A . 
I 5 HOH 253 953  143 HOH HOH A . 
I 5 HOH 254 954  586 HOH HOH A . 
I 5 HOH 255 955  346 HOH HOH A . 
I 5 HOH 256 956  97  HOH HOH A . 
I 5 HOH 257 957  39  HOH HOH A . 
I 5 HOH 258 958  500 HOH HOH A . 
I 5 HOH 259 959  91  HOH HOH A . 
I 5 HOH 260 960  510 HOH HOH A . 
I 5 HOH 261 961  130 HOH HOH A . 
I 5 HOH 262 962  333 HOH HOH A . 
I 5 HOH 263 963  397 HOH HOH A . 
I 5 HOH 264 964  682 HOH HOH A . 
I 5 HOH 265 965  276 HOH HOH A . 
I 5 HOH 266 966  186 HOH HOH A . 
I 5 HOH 267 967  309 HOH HOH A . 
I 5 HOH 268 968  515 HOH HOH A . 
I 5 HOH 269 969  576 HOH HOH A . 
I 5 HOH 270 970  214 HOH HOH A . 
I 5 HOH 271 971  189 HOH HOH A . 
I 5 HOH 272 972  302 HOH HOH A . 
I 5 HOH 273 973  452 HOH HOH A . 
I 5 HOH 274 974  27  HOH HOH A . 
I 5 HOH 275 975  469 HOH HOH A . 
I 5 HOH 276 976  84  HOH HOH A . 
I 5 HOH 277 977  430 HOH HOH A . 
I 5 HOH 278 978  516 HOH HOH A . 
I 5 HOH 279 979  418 HOH HOH A . 
I 5 HOH 280 980  540 HOH HOH A . 
I 5 HOH 281 981  485 HOH HOH A . 
I 5 HOH 282 982  106 HOH HOH A . 
I 5 HOH 283 983  129 HOH HOH A . 
I 5 HOH 284 984  468 HOH HOH A . 
I 5 HOH 285 985  508 HOH HOH A . 
I 5 HOH 286 986  50  HOH HOH A . 
I 5 HOH 287 987  507 HOH HOH A . 
I 5 HOH 288 988  675 HOH HOH A . 
I 5 HOH 289 989  519 HOH HOH A . 
I 5 HOH 290 990  171 HOH HOH A . 
I 5 HOH 291 991  432 HOH HOH A . 
I 5 HOH 292 992  642 HOH HOH A . 
I 5 HOH 293 993  269 HOH HOH A . 
I 5 HOH 294 994  555 HOH HOH A . 
I 5 HOH 295 995  46  HOH HOH A . 
I 5 HOH 296 996  554 HOH HOH A . 
I 5 HOH 297 997  164 HOH HOH A . 
I 5 HOH 298 998  385 HOH HOH A . 
I 5 HOH 299 999  403 HOH HOH A . 
I 5 HOH 300 1000 278 HOH HOH A . 
I 5 HOH 301 1001 161 HOH HOH A . 
I 5 HOH 302 1002 266 HOH HOH A . 
I 5 HOH 303 1003 191 HOH HOH A . 
I 5 HOH 304 1004 550 HOH HOH A . 
I 5 HOH 305 1005 699 HOH HOH A . 
I 5 HOH 306 1006 245 HOH HOH A . 
I 5 HOH 307 1007 259 HOH HOH A . 
I 5 HOH 308 1008 702 HOH HOH A . 
I 5 HOH 309 1009 474 HOH HOH A . 
I 5 HOH 310 1010 201 HOH HOH A . 
I 5 HOH 311 1011 706 HOH HOH A . 
I 5 HOH 312 1012 423 HOH HOH A . 
I 5 HOH 313 1013 412 HOH HOH A . 
I 5 HOH 314 1014 379 HOH HOH A . 
I 5 HOH 315 1015 677 HOH HOH A . 
I 5 HOH 316 1016 377 HOH HOH A . 
I 5 HOH 317 1017 391 HOH HOH A . 
I 5 HOH 318 1018 690 HOH HOH A . 
I 5 HOH 319 1019 713 HOH HOH A . 
I 5 HOH 320 1020 408 HOH HOH A . 
I 5 HOH 321 1021 416 HOH HOH A . 
I 5 HOH 322 1022 233 HOH HOH A . 
I 5 HOH 323 1023 579 HOH HOH A . 
I 5 HOH 324 1024 415 HOH HOH A . 
I 5 HOH 325 1025 727 HOH HOH A . 
I 5 HOH 326 1026 354 HOH HOH A . 
I 5 HOH 327 1027 732 HOH HOH A . 
I 5 HOH 328 1028 723 HOH HOH A . 
I 5 HOH 329 1029 734 HOH HOH A . 
I 5 HOH 330 1030 426 HOH HOH A . 
I 5 HOH 331 1031 664 HOH HOH A . 
I 5 HOH 332 1032 400 HOH HOH A . 
I 5 HOH 333 1033 338 HOH HOH A . 
I 5 HOH 334 1034 712 HOH HOH A . 
I 5 HOH 335 1035 162 HOH HOH A . 
I 5 HOH 336 1036 122 HOH HOH A . 
I 5 HOH 337 1037 422 HOH HOH A . 
I 5 HOH 338 1038 417 HOH HOH A . 
I 5 HOH 339 1039 274 HOH HOH A . 
I 5 HOH 340 1040 509 HOH HOH A . 
I 5 HOH 341 1041 244 HOH HOH A . 
I 5 HOH 342 1042 669 HOH HOH A . 
I 5 HOH 343 1043 700 HOH HOH A . 
I 5 HOH 344 1044 678 HOH HOH A . 
I 5 HOH 345 1045 392 HOH HOH A . 
I 5 HOH 346 1046 522 HOH HOH A . 
I 5 HOH 347 1047 363 HOH HOH A . 
I 5 HOH 348 1048 705 HOH HOH A . 
I 5 HOH 349 1049 720 HOH HOH A . 
I 5 HOH 350 1050 373 HOH HOH A . 
I 5 HOH 351 1051 684 HOH HOH A . 
I 5 HOH 352 1052 493 HOH HOH A . 
I 5 HOH 353 1053 737 HOH HOH A . 
I 5 HOH 354 1054 667 HOH HOH A . 
I 5 HOH 355 1055 329 HOH HOH A . 
I 5 HOH 356 1056 413 HOH HOH A . 
I 5 HOH 357 1057 739 HOH HOH A . 
I 5 HOH 358 1058 140 HOH HOH A . 
I 5 HOH 359 1059 77  HOH HOH A . 
I 5 HOH 360 1060 446 HOH HOH A . 
I 5 HOH 361 1061 715 HOH HOH A . 
I 5 HOH 362 1062 251 HOH HOH A . 
I 5 HOH 363 1063 668 HOH HOH A . 
I 5 HOH 364 1064 282 HOH HOH A . 
I 5 HOH 365 1065 697 HOH HOH A . 
I 5 HOH 366 1066 523 HOH HOH A . 
I 5 HOH 367 1067 349 HOH HOH A . 
I 5 HOH 368 1068 707 HOH HOH A . 
I 5 HOH 369 1069 671 HOH HOH A . 
I 5 HOH 370 1070 670 HOH HOH A . 
I 5 HOH 371 1071 665 HOH HOH A . 
I 5 HOH 372 1072 628 HOH HOH A . 
I 5 HOH 373 1073 281 HOH HOH A . 
I 5 HOH 374 1074 272 HOH HOH A . 
I 5 HOH 375 1075 374 HOH HOH A . 
I 5 HOH 376 1076 458 HOH HOH A . 
I 5 HOH 377 1077 719 HOH HOH A . 
I 5 HOH 378 1078 494 HOH HOH A . 
I 5 HOH 379 1079 687 HOH HOH A . 
I 5 HOH 380 1080 447 HOH HOH A . 
I 5 HOH 381 1081 718 HOH HOH A . 
I 5 HOH 382 1082 738 HOH HOH A . 
J 5 HOH 1   701  616 HOH HOH B . 
J 5 HOH 2   702  78  HOH HOH B . 
J 5 HOH 3   703  325 HOH HOH B . 
J 5 HOH 4   704  624 HOH HOH B . 
J 5 HOH 5   705  528 HOH HOH B . 
J 5 HOH 6   706  366 HOH HOH B . 
J 5 HOH 7   707  612 HOH HOH B . 
J 5 HOH 8   708  740 HOH HOH B . 
J 5 HOH 9   709  265 HOH HOH B . 
J 5 HOH 10  710  117 HOH HOH B . 
J 5 HOH 11  711  535 HOH HOH B . 
J 5 HOH 12  712  695 HOH HOH B . 
J 5 HOH 13  713  520 HOH HOH B . 
J 5 HOH 14  714  471 HOH HOH B . 
J 5 HOH 15  715  617 HOH HOH B . 
J 5 HOH 16  716  527 HOH HOH B . 
J 5 HOH 17  717  590 HOH HOH B . 
J 5 HOH 18  718  549 HOH HOH B . 
J 5 HOH 19  719  491 HOH HOH B . 
J 5 HOH 20  720  564 HOH HOH B . 
J 5 HOH 21  721  383 HOH HOH B . 
J 5 HOH 22  722  156 HOH HOH B . 
J 5 HOH 23  723  253 HOH HOH B . 
J 5 HOH 24  724  655 HOH HOH B . 
J 5 HOH 25  725  387 HOH HOH B . 
J 5 HOH 26  726  212 HOH HOH B . 
J 5 HOH 27  727  311 HOH HOH B . 
J 5 HOH 28  728  518 HOH HOH B . 
J 5 HOH 29  729  489 HOH HOH B . 
J 5 HOH 30  730  142 HOH HOH B . 
J 5 HOH 31  731  613 HOH HOH B . 
J 5 HOH 32  732  534 HOH HOH B . 
J 5 HOH 33  733  246 HOH HOH B . 
J 5 HOH 34  734  348 HOH HOH B . 
J 5 HOH 35  735  526 HOH HOH B . 
J 5 HOH 36  736  342 HOH HOH B . 
J 5 HOH 37  737  289 HOH HOH B . 
J 5 HOH 38  738  133 HOH HOH B . 
J 5 HOH 39  739  261 HOH HOH B . 
J 5 HOH 40  740  303 HOH HOH B . 
J 5 HOH 41  741  399 HOH HOH B . 
J 5 HOH 42  742  335 HOH HOH B . 
J 5 HOH 43  743  264 HOH HOH B . 
J 5 HOH 44  744  187 HOH HOH B . 
J 5 HOH 45  745  287 HOH HOH B . 
J 5 HOH 46  746  340 HOH HOH B . 
J 5 HOH 47  747  398 HOH HOH B . 
J 5 HOH 48  748  631 HOH HOH B . 
J 5 HOH 49  749  611 HOH HOH B . 
J 5 HOH 50  750  7   HOH HOH B . 
J 5 HOH 51  751  636 HOH HOH B . 
J 5 HOH 52  752  560 HOH HOH B . 
J 5 HOH 53  753  581 HOH HOH B . 
J 5 HOH 54  754  502 HOH HOH B . 
J 5 HOH 55  755  134 HOH HOH B . 
J 5 HOH 56  756  15  HOH HOH B . 
J 5 HOH 57  757  174 HOH HOH B . 
J 5 HOH 58  758  69  HOH HOH B . 
J 5 HOH 59  759  503 HOH HOH B . 
J 5 HOH 60  760  648 HOH HOH B . 
J 5 HOH 61  761  175 HOH HOH B . 
J 5 HOH 62  762  505 HOH HOH B . 
J 5 HOH 63  763  585 HOH HOH B . 
J 5 HOH 64  764  115 HOH HOH B . 
J 5 HOH 65  765  323 HOH HOH B . 
J 5 HOH 66  766  256 HOH HOH B . 
J 5 HOH 67  767  433 HOH HOH B . 
J 5 HOH 68  768  395 HOH HOH B . 
J 5 HOH 69  769  301 HOH HOH B . 
J 5 HOH 70  770  444 HOH HOH B . 
J 5 HOH 71  771  83  HOH HOH B . 
J 5 HOH 72  772  132 HOH HOH B . 
J 5 HOH 73  773  479 HOH HOH B . 
J 5 HOH 74  774  65  HOH HOH B . 
J 5 HOH 75  775  116 HOH HOH B . 
J 5 HOH 76  776  698 HOH HOH B . 
J 5 HOH 77  777  539 HOH HOH B . 
J 5 HOH 78  778  634 HOH HOH B . 
J 5 HOH 79  779  600 HOH HOH B . 
J 5 HOH 80  780  314 HOH HOH B . 
J 5 HOH 81  781  566 HOH HOH B . 
J 5 HOH 82  782  380 HOH HOH B . 
J 5 HOH 83  783  388 HOH HOH B . 
J 5 HOH 84  784  568 HOH HOH B . 
J 5 HOH 85  785  544 HOH HOH B . 
J 5 HOH 86  786  216 HOH HOH B . 
J 5 HOH 87  787  436 HOH HOH B . 
J 5 HOH 88  788  496 HOH HOH B . 
J 5 HOH 89  789  124 HOH HOH B . 
J 5 HOH 90  790  553 HOH HOH B . 
J 5 HOH 91  791  394 HOH HOH B . 
J 5 HOH 92  792  570 HOH HOH B . 
J 5 HOH 93  793  607 HOH HOH B . 
J 5 HOH 94  794  213 HOH HOH B . 
J 5 HOH 95  795  285 HOH HOH B . 
J 5 HOH 96  796  155 HOH HOH B . 
J 5 HOH 97  797  328 HOH HOH B . 
J 5 HOH 98  798  12  HOH HOH B . 
J 5 HOH 99  799  193 HOH HOH B . 
J 5 HOH 100 800  35  HOH HOH B . 
J 5 HOH 101 801  294 HOH HOH B . 
J 5 HOH 102 802  584 HOH HOH B . 
J 5 HOH 103 803  277 HOH HOH B . 
J 5 HOH 104 804  88  HOH HOH B . 
J 5 HOH 105 805  107 HOH HOH B . 
J 5 HOH 106 806  113 HOH HOH B . 
J 5 HOH 107 807  326 HOH HOH B . 
J 5 HOH 108 808  543 HOH HOH B . 
J 5 HOH 109 809  1   HOH HOH B . 
J 5 HOH 110 810  167 HOH HOH B . 
J 5 HOH 111 811  52  HOH HOH B . 
J 5 HOH 112 812  85  HOH HOH B . 
J 5 HOH 113 813  626 HOH HOH B . 
J 5 HOH 114 814  28  HOH HOH B . 
J 5 HOH 115 815  372 HOH HOH B . 
J 5 HOH 116 816  506 HOH HOH B . 
J 5 HOH 117 817  179 HOH HOH B . 
J 5 HOH 118 818  248 HOH HOH B . 
J 5 HOH 119 819  10  HOH HOH B . 
J 5 HOH 120 820  382 HOH HOH B . 
J 5 HOH 121 821  390 HOH HOH B . 
J 5 HOH 122 822  121 HOH HOH B . 
J 5 HOH 123 823  463 HOH HOH B . 
J 5 HOH 124 824  364 HOH HOH B . 
J 5 HOH 125 825  126 HOH HOH B . 
J 5 HOH 126 826  497 HOH HOH B . 
J 5 HOH 127 827  119 HOH HOH B . 
J 5 HOH 128 828  48  HOH HOH B . 
J 5 HOH 129 829  16  HOH HOH B . 
J 5 HOH 130 830  188 HOH HOH B . 
J 5 HOH 131 831  173 HOH HOH B . 
J 5 HOH 132 832  498 HOH HOH B . 
J 5 HOH 133 833  59  HOH HOH B . 
J 5 HOH 134 834  339 HOH HOH B . 
J 5 HOH 135 835  135 HOH HOH B . 
J 5 HOH 136 836  545 HOH HOH B . 
J 5 HOH 137 837  90  HOH HOH B . 
J 5 HOH 138 838  215 HOH HOH B . 
J 5 HOH 139 839  680 HOH HOH B . 
J 5 HOH 140 840  11  HOH HOH B . 
J 5 HOH 141 841  701 HOH HOH B . 
J 5 HOH 142 842  66  HOH HOH B . 
J 5 HOH 143 843  5   HOH HOH B . 
J 5 HOH 144 844  71  HOH HOH B . 
J 5 HOH 145 845  299 HOH HOH B . 
J 5 HOH 146 846  190 HOH HOH B . 
J 5 HOH 147 847  320 HOH HOH B . 
J 5 HOH 148 848  575 HOH HOH B . 
J 5 HOH 149 849  563 HOH HOH B . 
J 5 HOH 150 850  192 HOH HOH B . 
J 5 HOH 151 851  63  HOH HOH B . 
J 5 HOH 152 852  225 HOH HOH B . 
J 5 HOH 153 853  578 HOH HOH B . 
J 5 HOH 154 854  238 HOH HOH B . 
J 5 HOH 155 855  476 HOH HOH B . 
J 5 HOH 156 856  319 HOH HOH B . 
J 5 HOH 157 857  235 HOH HOH B . 
J 5 HOH 158 858  231 HOH HOH B . 
J 5 HOH 159 859  286 HOH HOH B . 
J 5 HOH 160 860  696 HOH HOH B . 
J 5 HOH 161 861  249 HOH HOH B . 
J 5 HOH 162 862  258 HOH HOH B . 
J 5 HOH 163 863  635 HOH HOH B . 
J 5 HOH 164 864  22  HOH HOH B . 
J 5 HOH 165 865  149 HOH HOH B . 
J 5 HOH 166 866  646 HOH HOH B . 
J 5 HOH 167 867  336 HOH HOH B . 
J 5 HOH 168 868  310 HOH HOH B . 
J 5 HOH 169 869  529 HOH HOH B . 
J 5 HOH 170 870  3   HOH HOH B . 
J 5 HOH 171 871  49  HOH HOH B . 
J 5 HOH 172 872  236 HOH HOH B . 
J 5 HOH 173 873  524 HOH HOH B . 
J 5 HOH 174 874  462 HOH HOH B . 
J 5 HOH 175 875  307 HOH HOH B . 
J 5 HOH 176 876  341 HOH HOH B . 
J 5 HOH 177 877  92  HOH HOH B . 
J 5 HOH 178 878  241 HOH HOH B . 
J 5 HOH 179 879  147 HOH HOH B . 
J 5 HOH 180 880  273 HOH HOH B . 
J 5 HOH 181 881  120 HOH HOH B . 
J 5 HOH 182 882  43  HOH HOH B . 
J 5 HOH 183 883  316 HOH HOH B . 
J 5 HOH 184 884  271 HOH HOH B . 
J 5 HOH 185 885  160 HOH HOH B . 
J 5 HOH 186 886  228 HOH HOH B . 
J 5 HOH 187 887  229 HOH HOH B . 
J 5 HOH 188 888  596 HOH HOH B . 
J 5 HOH 189 889  679 HOH HOH B . 
J 5 HOH 190 890  525 HOH HOH B . 
J 5 HOH 191 891  242 HOH HOH B . 
J 5 HOH 192 892  533 HOH HOH B . 
J 5 HOH 193 893  25  HOH HOH B . 
J 5 HOH 194 894  532 HOH HOH B . 
J 5 HOH 195 895  386 HOH HOH B . 
J 5 HOH 196 896  371 HOH HOH B . 
J 5 HOH 197 897  127 HOH HOH B . 
J 5 HOH 198 898  89  HOH HOH B . 
J 5 HOH 199 899  72  HOH HOH B . 
J 5 HOH 200 900  138 HOH HOH B . 
J 5 HOH 201 901  68  HOH HOH B . 
J 5 HOH 202 902  318 HOH HOH B . 
J 5 HOH 203 903  605 HOH HOH B . 
J 5 HOH 204 904  199 HOH HOH B . 
J 5 HOH 205 905  166 HOH HOH B . 
J 5 HOH 206 906  102 HOH HOH B . 
J 5 HOH 207 907  297 HOH HOH B . 
J 5 HOH 208 908  31  HOH HOH B . 
J 5 HOH 209 909  352 HOH HOH B . 
J 5 HOH 210 910  633 HOH HOH B . 
J 5 HOH 211 911  304 HOH HOH B . 
J 5 HOH 212 912  461 HOH HOH B . 
J 5 HOH 213 913  592 HOH HOH B . 
J 5 HOH 214 914  306 HOH HOH B . 
J 5 HOH 215 915  369 HOH HOH B . 
J 5 HOH 216 916  207 HOH HOH B . 
J 5 HOH 217 917  531 HOH HOH B . 
J 5 HOH 218 918  305 HOH HOH B . 
J 5 HOH 219 919  357 HOH HOH B . 
J 5 HOH 220 920  103 HOH HOH B . 
J 5 HOH 221 921  640 HOH HOH B . 
J 5 HOH 222 922  473 HOH HOH B . 
J 5 HOH 223 923  288 HOH HOH B . 
J 5 HOH 224 924  170 HOH HOH B . 
J 5 HOH 225 925  431 HOH HOH B . 
J 5 HOH 226 926  111 HOH HOH B . 
J 5 HOH 227 927  82  HOH HOH B . 
J 5 HOH 228 928  18  HOH HOH B . 
J 5 HOH 229 929  389 HOH HOH B . 
J 5 HOH 230 930  313 HOH HOH B . 
J 5 HOH 231 931  197 HOH HOH B . 
J 5 HOH 232 932  345 HOH HOH B . 
J 5 HOH 233 933  567 HOH HOH B . 
J 5 HOH 234 934  632 HOH HOH B . 
J 5 HOH 235 935  262 HOH HOH B . 
J 5 HOH 236 936  547 HOH HOH B . 
J 5 HOH 237 937  224 HOH HOH B . 
J 5 HOH 238 938  165 HOH HOH B . 
J 5 HOH 239 939  114 HOH HOH B . 
J 5 HOH 240 940  347 HOH HOH B . 
J 5 HOH 241 941  368 HOH HOH B . 
J 5 HOH 242 942  434 HOH HOH B . 
J 5 HOH 243 943  54  HOH HOH B . 
J 5 HOH 244 944  606 HOH HOH B . 
J 5 HOH 245 945  464 HOH HOH B . 
J 5 HOH 246 946  546 HOH HOH B . 
J 5 HOH 247 947  598 HOH HOH B . 
J 5 HOH 248 948  128 HOH HOH B . 
J 5 HOH 249 949  172 HOH HOH B . 
J 5 HOH 250 950  362 HOH HOH B . 
J 5 HOH 251 951  621 HOH HOH B . 
J 5 HOH 252 952  101 HOH HOH B . 
J 5 HOH 253 953  141 HOH HOH B . 
J 5 HOH 254 954  490 HOH HOH B . 
J 5 HOH 255 955  375 HOH HOH B . 
J 5 HOH 256 956  492 HOH HOH B . 
J 5 HOH 257 957  402 HOH HOH B . 
J 5 HOH 258 958  658 HOH HOH B . 
J 5 HOH 259 959  41  HOH HOH B . 
J 5 HOH 260 960  230 HOH HOH B . 
J 5 HOH 261 961  537 HOH HOH B . 
J 5 HOH 262 962  649 HOH HOH B . 
J 5 HOH 263 963  558 HOH HOH B . 
J 5 HOH 264 964  210 HOH HOH B . 
J 5 HOH 265 965  618 HOH HOH B . 
J 5 HOH 266 966  482 HOH HOH B . 
J 5 HOH 267 967  211 HOH HOH B . 
J 5 HOH 268 968  169 HOH HOH B . 
J 5 HOH 269 969  609 HOH HOH B . 
J 5 HOH 270 970  250 HOH HOH B . 
J 5 HOH 271 971  185 HOH HOH B . 
J 5 HOH 272 972  209 HOH HOH B . 
J 5 HOH 273 973  561 HOH HOH B . 
J 5 HOH 274 974  629 HOH HOH B . 
J 5 HOH 275 975  356 HOH HOH B . 
J 5 HOH 276 976  454 HOH HOH B . 
J 5 HOH 277 977  551 HOH HOH B . 
J 5 HOH 278 978  194 HOH HOH B . 
J 5 HOH 279 979  298 HOH HOH B . 
J 5 HOH 280 980  337 HOH HOH B . 
J 5 HOH 281 981  67  HOH HOH B . 
J 5 HOH 282 982  80  HOH HOH B . 
J 5 HOH 283 983  60  HOH HOH B . 
J 5 HOH 284 984  653 HOH HOH B . 
J 5 HOH 285 985  24  HOH HOH B . 
J 5 HOH 286 986  582 HOH HOH B . 
J 5 HOH 287 987  659 HOH HOH B . 
J 5 HOH 288 988  226 HOH HOH B . 
J 5 HOH 289 989  660 HOH HOH B . 
J 5 HOH 290 990  650 HOH HOH B . 
J 5 HOH 291 991  321 HOH HOH B . 
J 5 HOH 292 992  295 HOH HOH B . 
J 5 HOH 293 993  610 HOH HOH B . 
J 5 HOH 294 994  603 HOH HOH B . 
J 5 HOH 295 995  643 HOH HOH B . 
J 5 HOH 296 996  381 HOH HOH B . 
J 5 HOH 297 997  151 HOH HOH B . 
J 5 HOH 298 998  58  HOH HOH B . 
J 5 HOH 299 999  322 HOH HOH B . 
J 5 HOH 300 1000 218 HOH HOH B . 
J 5 HOH 301 1001 125 HOH HOH B . 
J 5 HOH 302 1002 312 HOH HOH B . 
J 5 HOH 303 1003 384 HOH HOH B . 
J 5 HOH 304 1004 396 HOH HOH B . 
J 5 HOH 305 1005 330 HOH HOH B . 
J 5 HOH 306 1006 370 HOH HOH B . 
J 5 HOH 307 1007 280 HOH HOH B . 
J 5 HOH 308 1008 429 HOH HOH B . 
J 5 HOH 309 1009 676 HOH HOH B . 
J 5 HOH 310 1010 367 HOH HOH B . 
J 5 HOH 311 1011 672 HOH HOH B . 
J 5 HOH 312 1012 317 HOH HOH B . 
J 5 HOH 313 1013 406 HOH HOH B . 
J 5 HOH 314 1014 639 HOH HOH B . 
J 5 HOH 315 1015 663 HOH HOH B . 
J 5 HOH 316 1016 711 HOH HOH B . 
J 5 HOH 317 1017 360 HOH HOH B . 
J 5 HOH 318 1018 148 HOH HOH B . 
J 5 HOH 319 1019 475 HOH HOH B . 
J 5 HOH 320 1020 405 HOH HOH B . 
J 5 HOH 321 1021 420 HOH HOH B . 
J 5 HOH 322 1022 736 HOH HOH B . 
J 5 HOH 323 1023 81  HOH HOH B . 
J 5 HOH 324 1024 184 HOH HOH B . 
J 5 HOH 325 1025 722 HOH HOH B . 
J 5 HOH 326 1026 96  HOH HOH B . 
J 5 HOH 327 1027 414 HOH HOH B . 
J 5 HOH 328 1028 694 HOH HOH B . 
J 5 HOH 329 1029 343 HOH HOH B . 
J 5 HOH 330 1030 619 HOH HOH B . 
J 5 HOH 331 1031 495 HOH HOH B . 
J 5 HOH 332 1032 703 HOH HOH B . 
J 5 HOH 333 1033 93  HOH HOH B . 
J 5 HOH 334 1034 501 HOH HOH B . 
J 5 HOH 335 1035 279 HOH HOH B . 
J 5 HOH 336 1036 409 HOH HOH B . 
J 5 HOH 337 1037 693 HOH HOH B . 
J 5 HOH 338 1038 183 HOH HOH B . 
J 5 HOH 339 1039 355 HOH HOH B . 
J 5 HOH 340 1040 673 HOH HOH B . 
J 5 HOH 341 1041 94  HOH HOH B . 
J 5 HOH 342 1042 45  HOH HOH B . 
J 5 HOH 343 1043 704 HOH HOH B . 
J 5 HOH 344 1044 361 HOH HOH B . 
J 5 HOH 345 1045 421 HOH HOH B . 
J 5 HOH 346 1046 666 HOH HOH B . 
J 5 HOH 347 1047 688 HOH HOH B . 
J 5 HOH 348 1048 393 HOH HOH B . 
J 5 HOH 349 1049 716 HOH HOH B . 
J 5 HOH 350 1050 689 HOH HOH B . 
J 5 HOH 351 1051 731 HOH HOH B . 
J 5 HOH 352 1052 324 HOH HOH B . 
J 5 HOH 353 1053 424 HOH HOH B . 
J 5 HOH 354 1054 729 HOH HOH B . 
J 5 HOH 355 1055 410 HOH HOH B . 
J 5 HOH 356 1056 144 HOH HOH B . 
J 5 HOH 357 1057 730 HOH HOH B . 
J 5 HOH 358 1058 425 HOH HOH B . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC ? ? ? 5.8.0419 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .        2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? SCALA  ? ? ? .        3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? MOLREP ? ? ? .        4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   98.35 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8RPF 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     81.985 
_cell.length_a_esd                 ? 
_cell.length_b                     76.780 
_cell.length_b_esd                 ? 
_cell.length_c                     88.222 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8RPF 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                4 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1 21 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8RPF 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.25 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          45.42 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              6.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '10%w/vPEG20000, 20%v/vPEGMME550 0.02Mof each alcohol 0.1MMES/imidazole pH6.5' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            291.15 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS3 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-10-26 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.979180 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'ALBA BEAMLINE XALOC' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.979180 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   XALOC 
_diffrn_source.pdbx_synchrotron_site       ALBA 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8RPF 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.00 
_reflns.d_resolution_low                               87.29 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     71851 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           98.2 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                2.4 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          12.4 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.044 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.00 
_reflns_shell.d_res_low                                     2.11 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           5.3 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             10383 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               5.3 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          97.5 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.150 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            2.61 
_refine.aniso_B[1][2]                            -0.00 
_refine.aniso_B[1][3]                            0.24 
_refine.aniso_B[2][2]                            -1.49 
_refine.aniso_B[2][3]                            -0.00 
_refine.aniso_B[3][3]                            -1.15 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               28.656 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.964 
_refine.correlation_coeff_Fo_to_Fc_free          0.943 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8RPF 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.00 
_refine.ls_d_res_low                             64.34 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     68336 
_refine.ls_number_reflns_R_free                  3493 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    97.95 
_refine.ls_percent_reflns_R_free                 4.9 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.16564 
_refine.ls_R_factor_R_free                       0.20791 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.16351 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.180 
_refine.pdbx_overall_ESU_R_Free                  0.156 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             3.714 
_refine.overall_SU_ML                            0.104 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.00 
_refine_hist.d_res_low                        64.34 
_refine_hist.number_atoms_solvent             740 
_refine_hist.number_atoms_total               9144 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        8394 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         10 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.007  0.012  8596  ? r_bond_refined_d             ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.016  8009  ? r_bond_other_d               ? ? 
'X-RAY DIFFRACTION' ? 1.565  1.820  11671 ? r_angle_refined_deg          ? ? 
'X-RAY DIFFRACTION' ? 0.545  1.752  18501 ? r_angle_other_deg            ? ? 
'X-RAY DIFFRACTION' ? 6.931  5.000  1068  ? r_dihedral_angle_1_deg       ? ? 
'X-RAY DIFFRACTION' ? 5.914  5.000  39    ? r_dihedral_angle_2_deg       ? ? 
'X-RAY DIFFRACTION' ? 13.174 10.000 1417  ? r_dihedral_angle_3_deg       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_dihedral_angle_4_deg       ? ? 
'X-RAY DIFFRACTION' ? 0.080  0.200  1295  ? r_chiral_restr               ? ? 
'X-RAY DIFFRACTION' ? 0.009  0.020  10067 ? r_gen_planes_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.020  1899  ? r_gen_planes_other           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbd_refined                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbd_other                  ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbtor_refined              ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbtor_other                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_xyhbond_nbd_refined        ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_xyhbond_nbd_other          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_metal_ion_refined          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_metal_ion_other            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_vdw_refined       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_vdw_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_hbond_refined     ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_hbond_other       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_metal_ion_refined ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_metal_ion_other   ? ? 
'X-RAY DIFFRACTION' ? 2.629  2.906  4275  ? r_mcbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 2.629  2.906  4275  ? r_mcbond_other               ? ? 
'X-RAY DIFFRACTION' ? 3.592  5.211  5342  ? r_mcangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 3.592  5.212  5343  ? r_mcangle_other              ? ? 
'X-RAY DIFFRACTION' ? 3.421  3.250  4321  ? r_scbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 3.421  3.250  4322  ? r_scbond_other               ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_scangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 5.176  5.805  6330  ? r_scangle_other              ? ? 
'X-RAY DIFFRACTION' ? 6.625  30.92  9927  ? r_long_range_B_refined       ? ? 
'X-RAY DIFFRACTION' ? 6.566  30.22  9754  ? r_long_range_B_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_rigid_bond_restr           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_sphericity_free            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_sphericity_bonded          ? ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       2.000 
_refine_ls_shell.d_res_low                        2.052 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             250 
_refine_ls_shell.number_reflns_R_work             5023 
_refine_ls_shell.percent_reflns_obs               97.36 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.R_factor_R_work                  0.191 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
_refine_ls_shell.R_factor_R_free                  0.253 
# 
_struct.entry_id                     8RPF 
_struct.title                        'Crystal structure of an alcohol-oxidase from Sphingobacterium daejeonense' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8RPF 
_struct_keywords.text            'ALCOHOL OXIDASE, SPHINGOBACTERIUM DAEJEONENSE, OXIDOREDUCTASE, FLAVOPROTEIN' 
_struct_keywords.pdbx_keywords   OXIDOREDUCTASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 2 ? 
E N N 3 ? 
F N N 4 ? 
G N N 3 ? 
H N N 4 ? 
I N N 5 ? 
J N N 5 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    PDB 
_struct_ref.db_code                    8RPF 
_struct_ref.pdbx_db_accession          8RPF 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   ? 
_struct_ref.pdbx_align_begin           1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8RPF A 1 ? 555 ? 8RPF -20 ? 534 ? -20 534 
2 1 8RPF B 1 ? 555 ? 8RPF -20 ? 534 ? -20 534 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_defined_assembly ? monomeric 1 
2 author_defined_assembly ? monomeric 1 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,C,D,E,F,I 
2 1 B,G,H,J     
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 THR A 33  ? THR A 43  ? THR A 12  THR A 22  1 ? 11 
HELX_P HELX_P2  AA2 ASN A 61  ? ILE A 66  ? ASN A 40  ILE A 45  5 ? 6  
HELX_P HELX_P3  AA3 ALA A 69  ? LEU A 74  ? ALA A 48  LEU A 53  5 ? 6  
HELX_P HELX_P4  AA4 GLN A 87  ? ASN A 91  ? GLN A 66  ASN A 70  5 ? 5  
HELX_P HELX_P5  AA5 GLY A 104 ? ILE A 109 ? GLY A 83  ILE A 88  5 ? 6  
HELX_P HELX_P6  AA6 THR A 118 ? GLN A 128 ? THR A 97  GLN A 107 1 ? 11 
HELX_P HELX_P7  AA7 ASN A 134 ? ILE A 145 ? ASN A 113 ILE A 124 1 ? 12 
HELX_P HELX_P8  AA8 PRO A 172 ? ALA A 184 ? PRO A 151 ALA A 163 1 ? 13 
HELX_P HELX_P9  AA9 THR A 214 ? LEU A 220 ? THR A 193 LEU A 199 1 ? 7  
HELX_P HELX_P10 AB1 THR A 221 ? ALA A 226 ? THR A 200 ALA A 205 1 ? 6  
HELX_P HELX_P11 AB2 ALA A 272 ? SER A 284 ? ALA A 251 SER A 263 1 ? 13 
HELX_P HELX_P12 AB3 PRO A 288 ? PHE A 295 ? PRO A 267 PHE A 274 1 ? 8  
HELX_P HELX_P13 AB4 SER A 335 ? LYS A 346 ? SER A 314 LYS A 325 1 ? 12 
HELX_P HELX_P14 AB5 GLY A 348 ? TYR A 352 ? GLY A 327 TYR A 331 5 ? 5  
HELX_P HELX_P15 AB6 GLU A 386 ? ALA A 390 ? GLU A 365 ALA A 369 5 ? 5  
HELX_P HELX_P16 AB7 ASP A 394 ? GLN A 398 ? ASP A 373 GLN A 377 5 ? 5  
HELX_P HELX_P17 AB8 SER A 437 ? LYS A 452 ? SER A 416 LYS A 431 1 ? 16 
HELX_P HELX_P18 AB9 ILE A 453 ? THR A 456 ? ILE A 432 THR A 435 5 ? 4  
HELX_P HELX_P19 AC1 LEU A 459 ? THR A 463 ? LEU A 438 THR A 442 5 ? 5  
HELX_P HELX_P20 AC2 THR A 473 ? ALA A 485 ? THR A 452 ALA A 464 1 ? 13 
HELX_P HELX_P21 AC3 ASP A 524 ? ILE A 528 ? ASP A 503 ILE A 507 5 ? 5  
HELX_P HELX_P22 AC4 THR A 536 ? ASN A 555 ? THR A 515 ASN A 534 1 ? 20 
HELX_P HELX_P23 AC5 THR B 33  ? THR B 43  ? THR B 12  THR B 22  1 ? 11 
HELX_P HELX_P24 AC6 ASN B 61  ? ILE B 66  ? ASN B 40  ILE B 45  5 ? 6  
HELX_P HELX_P25 AC7 ALA B 69  ? LEU B 74  ? ALA B 48  LEU B 53  5 ? 6  
HELX_P HELX_P26 AC8 THR B 88  ? ASN B 91  ? THR B 67  ASN B 70  5 ? 4  
HELX_P HELX_P27 AC9 GLY B 104 ? ILE B 109 ? GLY B 83  ILE B 88  5 ? 6  
HELX_P HELX_P28 AD1 THR B 118 ? GLN B 128 ? THR B 97  GLN B 107 1 ? 11 
HELX_P HELX_P29 AD2 ASN B 134 ? ILE B 145 ? ASN B 113 ILE B 124 1 ? 12 
HELX_P HELX_P30 AD3 PRO B 172 ? ALA B 184 ? PRO B 151 ALA B 163 1 ? 13 
HELX_P HELX_P31 AD4 THR B 214 ? LEU B 220 ? THR B 193 LEU B 199 1 ? 7  
HELX_P HELX_P32 AD5 THR B 221 ? ALA B 226 ? THR B 200 ALA B 205 1 ? 6  
HELX_P HELX_P33 AD6 ALA B 272 ? SER B 284 ? ALA B 251 SER B 263 1 ? 13 
HELX_P HELX_P34 AD7 PRO B 288 ? PHE B 295 ? PRO B 267 PHE B 274 1 ? 8  
HELX_P HELX_P35 AD8 SER B 335 ? LYS B 346 ? SER B 314 LYS B 325 1 ? 12 
HELX_P HELX_P36 AD9 GLY B 348 ? TYR B 352 ? GLY B 327 TYR B 331 5 ? 5  
HELX_P HELX_P37 AE1 GLU B 386 ? ALA B 390 ? GLU B 365 ALA B 369 5 ? 5  
HELX_P HELX_P38 AE2 ASP B 394 ? GLN B 398 ? ASP B 373 GLN B 377 5 ? 5  
HELX_P HELX_P39 AE3 SER B 437 ? LYS B 452 ? SER B 416 LYS B 431 1 ? 16 
HELX_P HELX_P40 AE4 ILE B 453 ? THR B 456 ? ILE B 432 THR B 435 5 ? 4  
HELX_P HELX_P41 AE5 LEU B 459 ? THR B 463 ? LEU B 438 THR B 442 5 ? 5  
HELX_P HELX_P42 AE6 THR B 473 ? ALA B 485 ? THR B 452 ALA B 464 1 ? 13 
HELX_P HELX_P43 AE7 ASP B 524 ? ILE B 528 ? ASP B 503 ILE B 507 5 ? 5  
HELX_P HELX_P44 AE8 THR B 536 ? ASN B 555 ? THR B 515 ASN B 534 1 ? 20 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 GLY 151 A . ? GLY 130 A PRO 152 A ? PRO 131 A 1 -0.65 
2 HIS 467 A . ? HIS 446 A PRO 468 A ? PRO 447 A 1 -7.79 
3 GLY 151 B . ? GLY 130 B PRO 152 B ? PRO 131 B 1 -0.74 
4 HIS 467 B . ? HIS 446 B PRO 468 B ? PRO 447 B 1 -6.34 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 6 ? 
AA2 ? 5 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
AA5 ? 7 ? 
AA6 ? 7 ? 
AA7 ? 2 ? 
AA8 ? 2 ? 
AA9 ? 2 ? 
AB1 ? 6 ? 
AB2 ? 5 ? 
AB3 ? 2 ? 
AB4 ? 2 ? 
AB5 ? 2 ? 
AB6 ? 7 ? 
AB7 ? 7 ? 
AB8 ? 2 ? 
AB9 ? 2 ? 
AC1 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? parallel      
AA1 3 4 ? parallel      
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? parallel      
AA2 3 4 ? parallel      
AA2 4 5 ? parallel      
AA3 1 2 ? parallel      
AA4 1 2 ? anti-parallel 
AA5 1 2 ? parallel      
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA5 4 5 ? anti-parallel 
AA5 5 6 ? anti-parallel 
AA5 6 7 ? anti-parallel 
AA6 1 2 ? parallel      
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA6 4 5 ? anti-parallel 
AA6 5 6 ? anti-parallel 
AA6 6 7 ? anti-parallel 
AA7 1 2 ? anti-parallel 
AA8 1 2 ? parallel      
AA9 1 2 ? anti-parallel 
AB1 1 2 ? parallel      
AB1 2 3 ? parallel      
AB1 3 4 ? parallel      
AB1 4 5 ? anti-parallel 
AB1 5 6 ? anti-parallel 
AB2 1 2 ? parallel      
AB2 2 3 ? parallel      
AB2 3 4 ? parallel      
AB2 4 5 ? parallel      
AB3 1 2 ? anti-parallel 
AB4 1 2 ? parallel      
AB5 1 2 ? anti-parallel 
AB6 1 2 ? parallel      
AB6 2 3 ? anti-parallel 
AB6 3 4 ? anti-parallel 
AB6 4 5 ? anti-parallel 
AB6 5 6 ? anti-parallel 
AB6 6 7 ? anti-parallel 
AB7 1 2 ? parallel      
AB7 2 3 ? anti-parallel 
AB7 3 4 ? anti-parallel 
AB7 4 5 ? anti-parallel 
AB7 5 6 ? anti-parallel 
AB7 6 7 ? anti-parallel 
AB8 1 2 ? anti-parallel 
AB9 1 2 ? parallel      
AC1 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 LEU A 230 ? ILE A 233 ? LEU A 209 ILE A 212 
AA1 2 VAL A 50  ? LEU A 53  ? VAL A 29  LEU A 32  
AA1 3 PHE A 24  ? VAL A 29  ? PHE A 3   VAL A 8   
AA1 4 GLN A 258 ? LEU A 270 ? GLN A 237 LEU A 249 
AA1 5 LYS A 247 ? ILE A 255 ? LYS A 226 ILE A 234 
AA1 6 ALA A 236 ? GLU A 244 ? ALA A 215 GLU A 223 
AA2 1 LEU A 230 ? ILE A 233 ? LEU A 209 ILE A 212 
AA2 2 VAL A 50  ? LEU A 53  ? VAL A 29  LEU A 32  
AA2 3 PHE A 24  ? VAL A 29  ? PHE A 3   VAL A 8   
AA2 4 GLN A 258 ? LEU A 270 ? GLN A 237 LEU A 249 
AA2 5 LEU A 520 ? VAL A 522 ? LEU A 499 VAL A 501 
AA3 1 GLU A 146 ? GLN A 147 ? GLU A 125 GLN A 126 
AA3 2 VAL A 162 ? LYS A 163 ? VAL A 141 LYS A 142 
AA4 1 THR A 165 ? ASP A 166 ? THR A 144 ASP A 145 
AA4 2 GLN A 204 ? LYS A 205 ? GLN A 183 LYS A 184 
AA5 1 GLU A 188 ? ILE A 189 ? GLU A 167 ILE A 168 
AA5 2 SER A 199 ? ILE A 202 ? SER A 178 ILE A 181 
AA5 3 GLY A 355 ? VAL A 361 ? GLY A 334 VAL A 340 
AA5 4 PHE A 372 ? THR A 377 ? PHE A 351 THR A 356 
AA5 5 GLY A 400 ? LEU A 407 ? GLY A 379 LEU A 386 
AA5 6 LEU A 314 ? VAL A 321 ? LEU A 293 VAL A 300 
AA5 7 LEU A 465 ? HIS A 467 ? LEU A 444 HIS A 446 
AA6 1 GLU A 188 ? ILE A 189 ? GLU A 167 ILE A 168 
AA6 2 SER A 199 ? ILE A 202 ? SER A 178 ILE A 181 
AA6 3 GLY A 355 ? VAL A 361 ? GLY A 334 VAL A 340 
AA6 4 PHE A 372 ? THR A 377 ? PHE A 351 THR A 356 
AA6 5 GLY A 400 ? LEU A 407 ? GLY A 379 LEU A 386 
AA6 6 LEU A 314 ? VAL A 321 ? LEU A 293 VAL A 300 
AA6 7 SER A 486 ? THR A 487 ? SER A 465 THR A 466 
AA7 1 TYR A 207 ? GLU A 208 ? TYR A 186 GLU A 187 
AA7 2 THR A 211 ? ARG A 212 ? THR A 190 ARG A 191 
AA8 1 VAL A 286 ? GLY A 287 ? VAL A 265 GLY A 266 
AA8 2 ALA A 301 ? ASN A 302 ? ALA A 280 ASN A 281 
AA9 1 GLN A 415 ? LEU A 417 ? GLN A 394 LEU A 396 
AA9 2 LEU A 428 ? ASN A 430 ? LEU A 407 ASN A 409 
AB1 1 LEU B 230 ? ILE B 233 ? LEU B 209 ILE B 212 
AB1 2 VAL B 50  ? LEU B 53  ? VAL B 29  LEU B 32  
AB1 3 PHE B 24  ? VAL B 29  ? PHE B 3   VAL B 8   
AB1 4 GLN B 258 ? LEU B 270 ? GLN B 237 LEU B 249 
AB1 5 LYS B 247 ? ILE B 255 ? LYS B 226 ILE B 234 
AB1 6 ALA B 236 ? GLU B 244 ? ALA B 215 GLU B 223 
AB2 1 LEU B 230 ? ILE B 233 ? LEU B 209 ILE B 212 
AB2 2 VAL B 50  ? LEU B 53  ? VAL B 29  LEU B 32  
AB2 3 PHE B 24  ? VAL B 29  ? PHE B 3   VAL B 8   
AB2 4 GLN B 258 ? LEU B 270 ? GLN B 237 LEU B 249 
AB2 5 LEU B 520 ? VAL B 522 ? LEU B 499 VAL B 501 
AB3 1 SER B 83  ? GLU B 86  ? SER B 62  GLU B 65  
AB3 2 SER B 94  ? TYR B 96  ? SER B 73  TYR B 75  
AB4 1 GLU B 146 ? GLN B 147 ? GLU B 125 GLN B 126 
AB4 2 VAL B 162 ? LYS B 163 ? VAL B 141 LYS B 142 
AB5 1 THR B 165 ? ASP B 166 ? THR B 144 ASP B 145 
AB5 2 GLN B 204 ? LYS B 205 ? GLN B 183 LYS B 184 
AB6 1 GLU B 188 ? ILE B 189 ? GLU B 167 ILE B 168 
AB6 2 SER B 199 ? ILE B 202 ? SER B 178 ILE B 181 
AB6 3 GLY B 355 ? VAL B 361 ? GLY B 334 VAL B 340 
AB6 4 PHE B 372 ? THR B 377 ? PHE B 351 THR B 356 
AB6 5 GLY B 400 ? LEU B 407 ? GLY B 379 LEU B 386 
AB6 6 LEU B 314 ? VAL B 321 ? LEU B 293 VAL B 300 
AB6 7 LEU B 465 ? HIS B 467 ? LEU B 444 HIS B 446 
AB7 1 GLU B 188 ? ILE B 189 ? GLU B 167 ILE B 168 
AB7 2 SER B 199 ? ILE B 202 ? SER B 178 ILE B 181 
AB7 3 GLY B 355 ? VAL B 361 ? GLY B 334 VAL B 340 
AB7 4 PHE B 372 ? THR B 377 ? PHE B 351 THR B 356 
AB7 5 GLY B 400 ? LEU B 407 ? GLY B 379 LEU B 386 
AB7 6 LEU B 314 ? VAL B 321 ? LEU B 293 VAL B 300 
AB7 7 SER B 486 ? THR B 487 ? SER B 465 THR B 466 
AB8 1 TYR B 207 ? GLU B 208 ? TYR B 186 GLU B 187 
AB8 2 THR B 211 ? ARG B 212 ? THR B 190 ARG B 191 
AB9 1 VAL B 286 ? GLY B 287 ? VAL B 265 GLY B 266 
AB9 2 ALA B 301 ? ASN B 302 ? ALA B 280 ASN B 281 
AC1 1 GLN B 415 ? LEU B 417 ? GLN B 394 LEU B 396 
AC1 2 LEU B 428 ? ASN B 430 ? LEU B 407 ASN B 409 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O THR A 231 ? O THR A 210 N LEU A 52  ? N LEU A 31  
AA1 2 3 O LEU A 51  ? O LEU A 30  N ILE A 28  ? N ILE A 7   
AA1 3 4 N VAL A 29  ? N VAL A 8   O ILE A 269 ? O ILE A 248 
AA1 4 5 O GLN A 260 ? O GLN A 239 N VAL A 253 ? N VAL A 232 
AA1 5 6 O GLU A 252 ? O GLU A 231 N ARG A 239 ? N ARG A 218 
AA2 1 2 O THR A 231 ? O THR A 210 N LEU A 52  ? N LEU A 31  
AA2 2 3 O LEU A 51  ? O LEU A 30  N ILE A 28  ? N ILE A 7   
AA2 3 4 N VAL A 29  ? N VAL A 8   O ILE A 269 ? O ILE A 248 
AA2 4 5 N LEU A 270 ? N LEU A 249 O ARG A 521 ? O ARG A 500 
AA3 1 2 N GLN A 147 ? N GLN A 126 O VAL A 162 ? O VAL A 141 
AA4 1 2 N THR A 165 ? N THR A 144 O LYS A 205 ? O LYS A 184 
AA5 1 2 N GLU A 188 ? N GLU A 167 O ILE A 200 ? O ILE A 179 
AA5 2 3 N ASP A 201 ? N ASP A 180 O SER A 358 ? O SER A 337 
AA5 3 4 N GLY A 359 ? N GLY A 338 O LEU A 374 ? O LEU A 353 
AA5 4 5 N ILE A 375 ? N ILE A 354 O THR A 404 ? O THR A 383 
AA5 5 6 O VAL A 405 ? O VAL A 384 N PHE A 316 ? N PHE A 295 
AA5 6 7 N LYS A 319 ? N LYS A 298 O HIS A 467 ? O HIS A 446 
AA6 1 2 N GLU A 188 ? N GLU A 167 O ILE A 200 ? O ILE A 179 
AA6 2 3 N ASP A 201 ? N ASP A 180 O SER A 358 ? O SER A 337 
AA6 3 4 N GLY A 359 ? N GLY A 338 O LEU A 374 ? O LEU A 353 
AA6 4 5 N ILE A 375 ? N ILE A 354 O THR A 404 ? O THR A 383 
AA6 5 6 O VAL A 405 ? O VAL A 384 N PHE A 316 ? N PHE A 295 
AA6 6 7 N MET A 315 ? N MET A 294 O SER A 486 ? O SER A 465 
AA7 1 2 N GLU A 208 ? N GLU A 187 O THR A 211 ? O THR A 190 
AA8 1 2 N GLY A 287 ? N GLY A 266 O ALA A 301 ? O ALA A 280 
AA9 1 2 N LEU A 417 ? N LEU A 396 O LEU A 428 ? O LEU A 407 
AB1 1 2 O THR B 231 ? O THR B 210 N LEU B 52  ? N LEU B 31  
AB1 2 3 O LEU B 51  ? O LEU B 30  N ILE B 28  ? N ILE B 7   
AB1 3 4 N VAL B 29  ? N VAL B 8   O ILE B 269 ? O ILE B 248 
AB1 4 5 O GLN B 260 ? O GLN B 239 N VAL B 253 ? N VAL B 232 
AB1 5 6 O GLU B 252 ? O GLU B 231 N ARG B 239 ? N ARG B 218 
AB2 1 2 O THR B 231 ? O THR B 210 N LEU B 52  ? N LEU B 31  
AB2 2 3 O LEU B 51  ? O LEU B 30  N ILE B 28  ? N ILE B 7   
AB2 3 4 N VAL B 29  ? N VAL B 8   O ILE B 269 ? O ILE B 248 
AB2 4 5 N LEU B 270 ? N LEU B 249 O ARG B 521 ? O ARG B 500 
AB3 1 2 N SER B 84  ? N SER B 63  O ILE B 95  ? O ILE B 74  
AB4 1 2 N GLN B 147 ? N GLN B 126 O VAL B 162 ? O VAL B 141 
AB5 1 2 N THR B 165 ? N THR B 144 O LYS B 205 ? O LYS B 184 
AB6 1 2 N GLU B 188 ? N GLU B 167 O ILE B 200 ? O ILE B 179 
AB6 2 3 N ASP B 201 ? N ASP B 180 O SER B 358 ? O SER B 337 
AB6 3 4 N GLY B 359 ? N GLY B 338 O LEU B 374 ? O LEU B 353 
AB6 4 5 N ILE B 375 ? N ILE B 354 O THR B 404 ? O THR B 383 
AB6 5 6 O VAL B 405 ? O VAL B 384 N PHE B 316 ? N PHE B 295 
AB6 6 7 N LYS B 319 ? N LYS B 298 O HIS B 467 ? O HIS B 446 
AB7 1 2 N GLU B 188 ? N GLU B 167 O ILE B 200 ? O ILE B 179 
AB7 2 3 N ASP B 201 ? N ASP B 180 O SER B 358 ? O SER B 337 
AB7 3 4 N GLY B 359 ? N GLY B 338 O LEU B 374 ? O LEU B 353 
AB7 4 5 N ILE B 375 ? N ILE B 354 O THR B 404 ? O THR B 383 
AB7 5 6 O VAL B 405 ? O VAL B 384 N PHE B 316 ? N PHE B 295 
AB7 6 7 N MET B 315 ? N MET B 294 O SER B 486 ? O SER B 465 
AB8 1 2 N GLU B 208 ? N GLU B 187 O THR B 211 ? O THR B 190 
AB9 1 2 N GLY B 287 ? N GLY B 266 O ALA B 301 ? O ALA B 280 
AC1 1 2 N LEU B 417 ? N LEU B 396 O LEU B 428 ? O LEU B 407 
# 
_pdbx_entry_details.entry_id                   8RPF 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1 1 CD A ARG 72  ? ? NE A ARG 72  ? ? CZ  A ARG 72  ? ? 133.54 123.60 9.94   1.40 N 
2 1 NE A ARG 72  ? ? CZ A ARG 72  ? ? NH1 A ARG 72  ? ? 125.32 120.30 5.02   0.50 N 
3 1 NE A ARG 72  ? ? CZ A ARG 72  ? ? NH2 A ARG 72  ? ? 115.67 120.30 -4.63  0.50 N 
4 1 N  A ARG 494 ? ? CA A ARG 494 ? ? CB  A ARG 494 ? ? 99.06  110.60 -11.54 1.80 N 
5 1 NE B ARG 72  ? ? CZ B ARG 72  ? ? NH1 B ARG 72  ? ? 126.32 120.30 6.02   0.50 N 
6 1 NE B ARG 72  ? ? CZ B ARG 72  ? ? NH2 B ARG 72  ? ? 116.01 120.30 -4.29  0.50 N 
7 1 N  B GLN 107 ? ? CA B GLN 107 ? ? CB  B GLN 107 ? ? 94.97  110.60 -15.63 1.80 N 
8 1 N  B ARG 494 ? ? CA B ARG 494 ? ? CB  B ARG 494 ? ? 98.67  110.60 -11.93 1.80 N 
9 1 NE B ARG 494 ? ? CZ B ARG 494 ? ? NH2 B ARG 494 ? ? 116.66 120.30 -3.64  0.50 N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ALA A 10  ? ? -97.76  56.86   
2  1 LEU A 199 ? ? -110.01 61.55   
3  1 LYS A 245 ? ? -107.83 -66.48  
4  1 PHE A 468 ? ? 71.45   37.22   
5  1 ASP A 503 ? ? -177.98 -168.75 
6  1 ALA B 10  ? ? -96.69  58.35   
7  1 VAL B 81  ? ? 178.78  153.94  
8  1 LEU B 199 ? ? -110.21 63.04   
9  1 LYS B 245 ? ? -109.12 -67.48  
10 1 ASP B 503 ? ? -174.97 -169.71 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 1081 ? 6.21 . 
2 1 O ? A HOH 1082 ? 6.44 . 
3 1 O ? B HOH 1057 ? 5.92 . 
4 1 O ? B HOH 1058 ? 6.38 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET -20 ? A MET 1  
2  1 Y 1 A GLY -19 ? A GLY 2  
3  1 Y 1 A SER -18 ? A SER 3  
4  1 Y 1 A SER -17 ? A SER 4  
5  1 Y 1 A HIS -16 ? A HIS 5  
6  1 Y 1 A HIS -15 ? A HIS 6  
7  1 Y 1 A HIS -14 ? A HIS 7  
8  1 Y 1 A HIS -13 ? A HIS 8  
9  1 Y 1 A HIS -12 ? A HIS 9  
10 1 Y 1 A HIS -11 ? A HIS 10 
11 1 Y 1 A SER -10 ? A SER 11 
12 1 Y 1 A SER -9  ? A SER 12 
13 1 Y 1 A GLY -8  ? A GLY 13 
14 1 Y 1 A LEU -7  ? A LEU 14 
15 1 Y 1 A VAL -6  ? A VAL 15 
16 1 Y 1 A PRO -5  ? A PRO 16 
17 1 Y 1 A ARG -4  ? A ARG 17 
18 1 Y 1 A GLY -3  ? A GLY 18 
19 1 Y 1 A SER -2  ? A SER 19 
20 1 Y 1 A HIS -1  ? A HIS 20 
21 1 Y 1 A MET 0   ? A MET 21 
22 1 Y 1 B MET -20 ? B MET 1  
23 1 Y 1 B GLY -19 ? B GLY 2  
24 1 Y 1 B SER -18 ? B SER 3  
25 1 Y 1 B SER -17 ? B SER 4  
26 1 Y 1 B HIS -16 ? B HIS 5  
27 1 Y 1 B HIS -15 ? B HIS 6  
28 1 Y 1 B HIS -14 ? B HIS 7  
29 1 Y 1 B HIS -13 ? B HIS 8  
30 1 Y 1 B HIS -12 ? B HIS 9  
31 1 Y 1 B HIS -11 ? B HIS 10 
32 1 Y 1 B SER -10 ? B SER 11 
33 1 Y 1 B SER -9  ? B SER 12 
34 1 Y 1 B GLY -8  ? B GLY 13 
35 1 Y 1 B LEU -7  ? B LEU 14 
36 1 Y 1 B VAL -6  ? B VAL 15 
37 1 Y 1 B PRO -5  ? B PRO 16 
38 1 Y 1 B ARG -4  ? B ARG 17 
39 1 Y 1 B GLY -3  ? B GLY 18 
40 1 Y 1 B SER -2  ? B SER 19 
41 1 Y 1 B HIS -1  ? B HIS 20 
42 1 Y 1 B MET 0   ? B MET 21 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
1BO C1     C N N 1   
1BO C2     C N N 2   
1BO C3     C N N 3   
1BO C4     C N N 4   
1BO OH     O N N 5   
1BO H11    H N N 6   
1BO H12    H N N 7   
1BO H13    H N N 8   
1BO H21    H N N 9   
1BO H22    H N N 10  
1BO H31    H N N 11  
1BO H32    H N N 12  
1BO H41    H N N 13  
1BO H42    H N N 14  
1BO HO     H N N 15  
ALA N      N N N 16  
ALA CA     C N S 17  
ALA C      C N N 18  
ALA O      O N N 19  
ALA CB     C N N 20  
ALA OXT    O N N 21  
ALA H      H N N 22  
ALA H2     H N N 23  
ALA HA     H N N 24  
ALA HB1    H N N 25  
ALA HB2    H N N 26  
ALA HB3    H N N 27  
ALA HXT    H N N 28  
ARG N      N N N 29  
ARG CA     C N S 30  
ARG C      C N N 31  
ARG O      O N N 32  
ARG CB     C N N 33  
ARG CG     C N N 34  
ARG CD     C N N 35  
ARG NE     N N N 36  
ARG CZ     C N N 37  
ARG NH1    N N N 38  
ARG NH2    N N N 39  
ARG OXT    O N N 40  
ARG H      H N N 41  
ARG H2     H N N 42  
ARG HA     H N N 43  
ARG HB2    H N N 44  
ARG HB3    H N N 45  
ARG HG2    H N N 46  
ARG HG3    H N N 47  
ARG HD2    H N N 48  
ARG HD3    H N N 49  
ARG HE     H N N 50  
ARG HH11   H N N 51  
ARG HH12   H N N 52  
ARG HH21   H N N 53  
ARG HH22   H N N 54  
ARG HXT    H N N 55  
ASN N      N N N 56  
ASN CA     C N S 57  
ASN C      C N N 58  
ASN O      O N N 59  
ASN CB     C N N 60  
ASN CG     C N N 61  
ASN OD1    O N N 62  
ASN ND2    N N N 63  
ASN OXT    O N N 64  
ASN H      H N N 65  
ASN H2     H N N 66  
ASN HA     H N N 67  
ASN HB2    H N N 68  
ASN HB3    H N N 69  
ASN HD21   H N N 70  
ASN HD22   H N N 71  
ASN HXT    H N N 72  
ASP N      N N N 73  
ASP CA     C N S 74  
ASP C      C N N 75  
ASP O      O N N 76  
ASP CB     C N N 77  
ASP CG     C N N 78  
ASP OD1    O N N 79  
ASP OD2    O N N 80  
ASP OXT    O N N 81  
ASP H      H N N 82  
ASP H2     H N N 83  
ASP HA     H N N 84  
ASP HB2    H N N 85  
ASP HB3    H N N 86  
ASP HD2    H N N 87  
ASP HXT    H N N 88  
FAD PA     P N R 89  
FAD O1A    O N N 90  
FAD O2A    O N N 91  
FAD O5B    O N N 92  
FAD C5B    C N N 93  
FAD C4B    C N R 94  
FAD O4B    O N N 95  
FAD C3B    C N S 96  
FAD O3B    O N N 97  
FAD C2B    C N R 98  
FAD O2B    O N N 99  
FAD C1B    C N R 100 
FAD N9A    N Y N 101 
FAD C8A    C Y N 102 
FAD N7A    N Y N 103 
FAD C5A    C Y N 104 
FAD C6A    C Y N 105 
FAD N6A    N N N 106 
FAD N1A    N Y N 107 
FAD C2A    C Y N 108 
FAD N3A    N Y N 109 
FAD C4A    C Y N 110 
FAD N1     N N N 111 
FAD C2     C N N 112 
FAD O2     O N N 113 
FAD N3     N N N 114 
FAD C4     C N N 115 
FAD O4     O N N 116 
FAD C4X    C N N 117 
FAD N5     N N N 118 
FAD C5X    C Y N 119 
FAD C6     C Y N 120 
FAD C7     C Y N 121 
FAD C7M    C N N 122 
FAD C8     C Y N 123 
FAD C8M    C N N 124 
FAD C9     C Y N 125 
FAD C9A    C Y N 126 
FAD N10    N N N 127 
FAD C10    C N N 128 
FAD "C1'"  C N N 129 
FAD "C2'"  C N S 130 
FAD "O2'"  O N N 131 
FAD "C3'"  C N S 132 
FAD "O3'"  O N N 133 
FAD "C4'"  C N R 134 
FAD "O4'"  O N N 135 
FAD "C5'"  C N N 136 
FAD "O5'"  O N N 137 
FAD P      P N R 138 
FAD O1P    O N N 139 
FAD O2P    O N N 140 
FAD O3P    O N N 141 
FAD HOA2   H N N 142 
FAD H51A   H N N 143 
FAD H52A   H N N 144 
FAD H4B    H N N 145 
FAD H3B    H N N 146 
FAD HO3A   H N N 147 
FAD H2B    H N N 148 
FAD HO2A   H N N 149 
FAD H1B    H N N 150 
FAD H8A    H N N 151 
FAD H61A   H N N 152 
FAD H62A   H N N 153 
FAD H2A    H N N 154 
FAD HN3    H N N 155 
FAD H6     H N N 156 
FAD HM71   H N N 157 
FAD HM72   H N N 158 
FAD HM73   H N N 159 
FAD HM81   H N N 160 
FAD HM82   H N N 161 
FAD HM83   H N N 162 
FAD H9     H N N 163 
FAD "H1'1" H N N 164 
FAD "H1'2" H N N 165 
FAD "H2'"  H N N 166 
FAD "HO2'" H N N 167 
FAD "H3'"  H N N 168 
FAD "HO3'" H N N 169 
FAD "H4'"  H N N 170 
FAD "HO4'" H N N 171 
FAD "H5'1" H N N 172 
FAD "H5'2" H N N 173 
FAD HOP2   H N N 174 
GLN N      N N N 175 
GLN CA     C N S 176 
GLN C      C N N 177 
GLN O      O N N 178 
GLN CB     C N N 179 
GLN CG     C N N 180 
GLN CD     C N N 181 
GLN OE1    O N N 182 
GLN NE2    N N N 183 
GLN OXT    O N N 184 
GLN H      H N N 185 
GLN H2     H N N 186 
GLN HA     H N N 187 
GLN HB2    H N N 188 
GLN HB3    H N N 189 
GLN HG2    H N N 190 
GLN HG3    H N N 191 
GLN HE21   H N N 192 
GLN HE22   H N N 193 
GLN HXT    H N N 194 
GLU N      N N N 195 
GLU CA     C N S 196 
GLU C      C N N 197 
GLU O      O N N 198 
GLU CB     C N N 199 
GLU CG     C N N 200 
GLU CD     C N N 201 
GLU OE1    O N N 202 
GLU OE2    O N N 203 
GLU OXT    O N N 204 
GLU H      H N N 205 
GLU H2     H N N 206 
GLU HA     H N N 207 
GLU HB2    H N N 208 
GLU HB3    H N N 209 
GLU HG2    H N N 210 
GLU HG3    H N N 211 
GLU HE2    H N N 212 
GLU HXT    H N N 213 
GLY N      N N N 214 
GLY CA     C N N 215 
GLY C      C N N 216 
GLY O      O N N 217 
GLY OXT    O N N 218 
GLY H      H N N 219 
GLY H2     H N N 220 
GLY HA2    H N N 221 
GLY HA3    H N N 222 
GLY HXT    H N N 223 
HEZ O1     O N N 224 
HEZ C1     C N N 225 
HEZ C2     C N N 226 
HEZ C3     C N N 227 
HEZ C4     C N N 228 
HEZ C5     C N N 229 
HEZ C6     C N N 230 
HEZ O6     O N N 231 
HEZ HO1    H N N 232 
HEZ H11    H N N 233 
HEZ H12    H N N 234 
HEZ H21    H N N 235 
HEZ H22    H N N 236 
HEZ H31    H N N 237 
HEZ H32    H N N 238 
HEZ H41    H N N 239 
HEZ H42    H N N 240 
HEZ H51    H N N 241 
HEZ H52    H N N 242 
HEZ H61    H N N 243 
HEZ H62    H N N 244 
HEZ HO6    H N N 245 
HIS N      N N N 246 
HIS CA     C N S 247 
HIS C      C N N 248 
HIS O      O N N 249 
HIS CB     C N N 250 
HIS CG     C Y N 251 
HIS ND1    N Y N 252 
HIS CD2    C Y N 253 
HIS CE1    C Y N 254 
HIS NE2    N Y N 255 
HIS OXT    O N N 256 
HIS H      H N N 257 
HIS H2     H N N 258 
HIS HA     H N N 259 
HIS HB2    H N N 260 
HIS HB3    H N N 261 
HIS HD1    H N N 262 
HIS HD2    H N N 263 
HIS HE1    H N N 264 
HIS HE2    H N N 265 
HIS HXT    H N N 266 
HOH O      O N N 267 
HOH H1     H N N 268 
HOH H2     H N N 269 
ILE N      N N N 270 
ILE CA     C N S 271 
ILE C      C N N 272 
ILE O      O N N 273 
ILE CB     C N S 274 
ILE CG1    C N N 275 
ILE CG2    C N N 276 
ILE CD1    C N N 277 
ILE OXT    O N N 278 
ILE H      H N N 279 
ILE H2     H N N 280 
ILE HA     H N N 281 
ILE HB     H N N 282 
ILE HG12   H N N 283 
ILE HG13   H N N 284 
ILE HG21   H N N 285 
ILE HG22   H N N 286 
ILE HG23   H N N 287 
ILE HD11   H N N 288 
ILE HD12   H N N 289 
ILE HD13   H N N 290 
ILE HXT    H N N 291 
LEU N      N N N 292 
LEU CA     C N S 293 
LEU C      C N N 294 
LEU O      O N N 295 
LEU CB     C N N 296 
LEU CG     C N N 297 
LEU CD1    C N N 298 
LEU CD2    C N N 299 
LEU OXT    O N N 300 
LEU H      H N N 301 
LEU H2     H N N 302 
LEU HA     H N N 303 
LEU HB2    H N N 304 
LEU HB3    H N N 305 
LEU HG     H N N 306 
LEU HD11   H N N 307 
LEU HD12   H N N 308 
LEU HD13   H N N 309 
LEU HD21   H N N 310 
LEU HD22   H N N 311 
LEU HD23   H N N 312 
LEU HXT    H N N 313 
LYS N      N N N 314 
LYS CA     C N S 315 
LYS C      C N N 316 
LYS O      O N N 317 
LYS CB     C N N 318 
LYS CG     C N N 319 
LYS CD     C N N 320 
LYS CE     C N N 321 
LYS NZ     N N N 322 
LYS OXT    O N N 323 
LYS H      H N N 324 
LYS H2     H N N 325 
LYS HA     H N N 326 
LYS HB2    H N N 327 
LYS HB3    H N N 328 
LYS HG2    H N N 329 
LYS HG3    H N N 330 
LYS HD2    H N N 331 
LYS HD3    H N N 332 
LYS HE2    H N N 333 
LYS HE3    H N N 334 
LYS HZ1    H N N 335 
LYS HZ2    H N N 336 
LYS HZ3    H N N 337 
LYS HXT    H N N 338 
MET N      N N N 339 
MET CA     C N S 340 
MET C      C N N 341 
MET O      O N N 342 
MET CB     C N N 343 
MET CG     C N N 344 
MET SD     S N N 345 
MET CE     C N N 346 
MET OXT    O N N 347 
MET H      H N N 348 
MET H2     H N N 349 
MET HA     H N N 350 
MET HB2    H N N 351 
MET HB3    H N N 352 
MET HG2    H N N 353 
MET HG3    H N N 354 
MET HE1    H N N 355 
MET HE2    H N N 356 
MET HE3    H N N 357 
MET HXT    H N N 358 
PHE N      N N N 359 
PHE CA     C N S 360 
PHE C      C N N 361 
PHE O      O N N 362 
PHE CB     C N N 363 
PHE CG     C Y N 364 
PHE CD1    C Y N 365 
PHE CD2    C Y N 366 
PHE CE1    C Y N 367 
PHE CE2    C Y N 368 
PHE CZ     C Y N 369 
PHE OXT    O N N 370 
PHE H      H N N 371 
PHE H2     H N N 372 
PHE HA     H N N 373 
PHE HB2    H N N 374 
PHE HB3    H N N 375 
PHE HD1    H N N 376 
PHE HD2    H N N 377 
PHE HE1    H N N 378 
PHE HE2    H N N 379 
PHE HZ     H N N 380 
PHE HXT    H N N 381 
PRO N      N N N 382 
PRO CA     C N S 383 
PRO C      C N N 384 
PRO O      O N N 385 
PRO CB     C N N 386 
PRO CG     C N N 387 
PRO CD     C N N 388 
PRO OXT    O N N 389 
PRO H      H N N 390 
PRO HA     H N N 391 
PRO HB2    H N N 392 
PRO HB3    H N N 393 
PRO HG2    H N N 394 
PRO HG3    H N N 395 
PRO HD2    H N N 396 
PRO HD3    H N N 397 
PRO HXT    H N N 398 
SER N      N N N 399 
SER CA     C N S 400 
SER C      C N N 401 
SER O      O N N 402 
SER CB     C N N 403 
SER OG     O N N 404 
SER OXT    O N N 405 
SER H      H N N 406 
SER H2     H N N 407 
SER HA     H N N 408 
SER HB2    H N N 409 
SER HB3    H N N 410 
SER HG     H N N 411 
SER HXT    H N N 412 
THR N      N N N 413 
THR CA     C N S 414 
THR C      C N N 415 
THR O      O N N 416 
THR CB     C N R 417 
THR OG1    O N N 418 
THR CG2    C N N 419 
THR OXT    O N N 420 
THR H      H N N 421 
THR H2     H N N 422 
THR HA     H N N 423 
THR HB     H N N 424 
THR HG1    H N N 425 
THR HG21   H N N 426 
THR HG22   H N N 427 
THR HG23   H N N 428 
THR HXT    H N N 429 
TRP N      N N N 430 
TRP CA     C N S 431 
TRP C      C N N 432 
TRP O      O N N 433 
TRP CB     C N N 434 
TRP CG     C Y N 435 
TRP CD1    C Y N 436 
TRP CD2    C Y N 437 
TRP NE1    N Y N 438 
TRP CE2    C Y N 439 
TRP CE3    C Y N 440 
TRP CZ2    C Y N 441 
TRP CZ3    C Y N 442 
TRP CH2    C Y N 443 
TRP OXT    O N N 444 
TRP H      H N N 445 
TRP H2     H N N 446 
TRP HA     H N N 447 
TRP HB2    H N N 448 
TRP HB3    H N N 449 
TRP HD1    H N N 450 
TRP HE1    H N N 451 
TRP HE3    H N N 452 
TRP HZ2    H N N 453 
TRP HZ3    H N N 454 
TRP HH2    H N N 455 
TRP HXT    H N N 456 
TYR N      N N N 457 
TYR CA     C N S 458 
TYR C      C N N 459 
TYR O      O N N 460 
TYR CB     C N N 461 
TYR CG     C Y N 462 
TYR CD1    C Y N 463 
TYR CD2    C Y N 464 
TYR CE1    C Y N 465 
TYR CE2    C Y N 466 
TYR CZ     C Y N 467 
TYR OH     O N N 468 
TYR OXT    O N N 469 
TYR H      H N N 470 
TYR H2     H N N 471 
TYR HA     H N N 472 
TYR HB2    H N N 473 
TYR HB3    H N N 474 
TYR HD1    H N N 475 
TYR HD2    H N N 476 
TYR HE1    H N N 477 
TYR HE2    H N N 478 
TYR HH     H N N 479 
TYR HXT    H N N 480 
VAL N      N N N 481 
VAL CA     C N S 482 
VAL C      C N N 483 
VAL O      O N N 484 
VAL CB     C N N 485 
VAL CG1    C N N 486 
VAL CG2    C N N 487 
VAL OXT    O N N 488 
VAL H      H N N 489 
VAL H2     H N N 490 
VAL HA     H N N 491 
VAL HB     H N N 492 
VAL HG11   H N N 493 
VAL HG12   H N N 494 
VAL HG13   H N N 495 
VAL HG21   H N N 496 
VAL HG22   H N N 497 
VAL HG23   H N N 498 
VAL HXT    H N N 499 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
1BO C1    C2     sing N N 1   
1BO C1    H11    sing N N 2   
1BO C1    H12    sing N N 3   
1BO C1    H13    sing N N 4   
1BO C2    C3     sing N N 5   
1BO C2    H21    sing N N 6   
1BO C2    H22    sing N N 7   
1BO C3    C4     sing N N 8   
1BO C3    H31    sing N N 9   
1BO C3    H32    sing N N 10  
1BO C4    OH     sing N N 11  
1BO C4    H41    sing N N 12  
1BO C4    H42    sing N N 13  
1BO OH    HO     sing N N 14  
ALA N     CA     sing N N 15  
ALA N     H      sing N N 16  
ALA N     H2     sing N N 17  
ALA CA    C      sing N N 18  
ALA CA    CB     sing N N 19  
ALA CA    HA     sing N N 20  
ALA C     O      doub N N 21  
ALA C     OXT    sing N N 22  
ALA CB    HB1    sing N N 23  
ALA CB    HB2    sing N N 24  
ALA CB    HB3    sing N N 25  
ALA OXT   HXT    sing N N 26  
ARG N     CA     sing N N 27  
ARG N     H      sing N N 28  
ARG N     H2     sing N N 29  
ARG CA    C      sing N N 30  
ARG CA    CB     sing N N 31  
ARG CA    HA     sing N N 32  
ARG C     O      doub N N 33  
ARG C     OXT    sing N N 34  
ARG CB    CG     sing N N 35  
ARG CB    HB2    sing N N 36  
ARG CB    HB3    sing N N 37  
ARG CG    CD     sing N N 38  
ARG CG    HG2    sing N N 39  
ARG CG    HG3    sing N N 40  
ARG CD    NE     sing N N 41  
ARG CD    HD2    sing N N 42  
ARG CD    HD3    sing N N 43  
ARG NE    CZ     sing N N 44  
ARG NE    HE     sing N N 45  
ARG CZ    NH1    sing N N 46  
ARG CZ    NH2    doub N N 47  
ARG NH1   HH11   sing N N 48  
ARG NH1   HH12   sing N N 49  
ARG NH2   HH21   sing N N 50  
ARG NH2   HH22   sing N N 51  
ARG OXT   HXT    sing N N 52  
ASN N     CA     sing N N 53  
ASN N     H      sing N N 54  
ASN N     H2     sing N N 55  
ASN CA    C      sing N N 56  
ASN CA    CB     sing N N 57  
ASN CA    HA     sing N N 58  
ASN C     O      doub N N 59  
ASN C     OXT    sing N N 60  
ASN CB    CG     sing N N 61  
ASN CB    HB2    sing N N 62  
ASN CB    HB3    sing N N 63  
ASN CG    OD1    doub N N 64  
ASN CG    ND2    sing N N 65  
ASN ND2   HD21   sing N N 66  
ASN ND2   HD22   sing N N 67  
ASN OXT   HXT    sing N N 68  
ASP N     CA     sing N N 69  
ASP N     H      sing N N 70  
ASP N     H2     sing N N 71  
ASP CA    C      sing N N 72  
ASP CA    CB     sing N N 73  
ASP CA    HA     sing N N 74  
ASP C     O      doub N N 75  
ASP C     OXT    sing N N 76  
ASP CB    CG     sing N N 77  
ASP CB    HB2    sing N N 78  
ASP CB    HB3    sing N N 79  
ASP CG    OD1    doub N N 80  
ASP CG    OD2    sing N N 81  
ASP OD2   HD2    sing N N 82  
ASP OXT   HXT    sing N N 83  
FAD PA    O1A    doub N N 84  
FAD PA    O2A    sing N N 85  
FAD PA    O5B    sing N N 86  
FAD PA    O3P    sing N N 87  
FAD O2A   HOA2   sing N N 88  
FAD O5B   C5B    sing N N 89  
FAD C5B   C4B    sing N N 90  
FAD C5B   H51A   sing N N 91  
FAD C5B   H52A   sing N N 92  
FAD C4B   O4B    sing N N 93  
FAD C4B   C3B    sing N N 94  
FAD C4B   H4B    sing N N 95  
FAD O4B   C1B    sing N N 96  
FAD C3B   O3B    sing N N 97  
FAD C3B   C2B    sing N N 98  
FAD C3B   H3B    sing N N 99  
FAD O3B   HO3A   sing N N 100 
FAD C2B   O2B    sing N N 101 
FAD C2B   C1B    sing N N 102 
FAD C2B   H2B    sing N N 103 
FAD O2B   HO2A   sing N N 104 
FAD C1B   N9A    sing N N 105 
FAD C1B   H1B    sing N N 106 
FAD N9A   C8A    sing Y N 107 
FAD N9A   C4A    sing Y N 108 
FAD C8A   N7A    doub Y N 109 
FAD C8A   H8A    sing N N 110 
FAD N7A   C5A    sing Y N 111 
FAD C5A   C6A    sing Y N 112 
FAD C5A   C4A    doub Y N 113 
FAD C6A   N6A    sing N N 114 
FAD C6A   N1A    doub Y N 115 
FAD N6A   H61A   sing N N 116 
FAD N6A   H62A   sing N N 117 
FAD N1A   C2A    sing Y N 118 
FAD C2A   N3A    doub Y N 119 
FAD C2A   H2A    sing N N 120 
FAD N3A   C4A    sing Y N 121 
FAD N1    C2     sing N N 122 
FAD N1    C10    doub N N 123 
FAD C2    O2     doub N N 124 
FAD C2    N3     sing N N 125 
FAD N3    C4     sing N N 126 
FAD N3    HN3    sing N N 127 
FAD C4    O4     doub N N 128 
FAD C4    C4X    sing N N 129 
FAD C4X   N5     doub N N 130 
FAD C4X   C10    sing N N 131 
FAD N5    C5X    sing N N 132 
FAD C5X   C6     doub Y N 133 
FAD C5X   C9A    sing Y N 134 
FAD C6    C7     sing Y N 135 
FAD C6    H6     sing N N 136 
FAD C7    C7M    sing N N 137 
FAD C7    C8     doub Y N 138 
FAD C7M   HM71   sing N N 139 
FAD C7M   HM72   sing N N 140 
FAD C7M   HM73   sing N N 141 
FAD C8    C8M    sing N N 142 
FAD C8    C9     sing Y N 143 
FAD C8M   HM81   sing N N 144 
FAD C8M   HM82   sing N N 145 
FAD C8M   HM83   sing N N 146 
FAD C9    C9A    doub Y N 147 
FAD C9    H9     sing N N 148 
FAD C9A   N10    sing N N 149 
FAD N10   C10    sing N N 150 
FAD N10   "C1'"  sing N N 151 
FAD "C1'" "C2'"  sing N N 152 
FAD "C1'" "H1'1" sing N N 153 
FAD "C1'" "H1'2" sing N N 154 
FAD "C2'" "O2'"  sing N N 155 
FAD "C2'" "C3'"  sing N N 156 
FAD "C2'" "H2'"  sing N N 157 
FAD "O2'" "HO2'" sing N N 158 
FAD "C3'" "O3'"  sing N N 159 
FAD "C3'" "C4'"  sing N N 160 
FAD "C3'" "H3'"  sing N N 161 
FAD "O3'" "HO3'" sing N N 162 
FAD "C4'" "O4'"  sing N N 163 
FAD "C4'" "C5'"  sing N N 164 
FAD "C4'" "H4'"  sing N N 165 
FAD "O4'" "HO4'" sing N N 166 
FAD "C5'" "O5'"  sing N N 167 
FAD "C5'" "H5'1" sing N N 168 
FAD "C5'" "H5'2" sing N N 169 
FAD "O5'" P      sing N N 170 
FAD P     O1P    doub N N 171 
FAD P     O2P    sing N N 172 
FAD P     O3P    sing N N 173 
FAD O2P   HOP2   sing N N 174 
GLN N     CA     sing N N 175 
GLN N     H      sing N N 176 
GLN N     H2     sing N N 177 
GLN CA    C      sing N N 178 
GLN CA    CB     sing N N 179 
GLN CA    HA     sing N N 180 
GLN C     O      doub N N 181 
GLN C     OXT    sing N N 182 
GLN CB    CG     sing N N 183 
GLN CB    HB2    sing N N 184 
GLN CB    HB3    sing N N 185 
GLN CG    CD     sing N N 186 
GLN CG    HG2    sing N N 187 
GLN CG    HG3    sing N N 188 
GLN CD    OE1    doub N N 189 
GLN CD    NE2    sing N N 190 
GLN NE2   HE21   sing N N 191 
GLN NE2   HE22   sing N N 192 
GLN OXT   HXT    sing N N 193 
GLU N     CA     sing N N 194 
GLU N     H      sing N N 195 
GLU N     H2     sing N N 196 
GLU CA    C      sing N N 197 
GLU CA    CB     sing N N 198 
GLU CA    HA     sing N N 199 
GLU C     O      doub N N 200 
GLU C     OXT    sing N N 201 
GLU CB    CG     sing N N 202 
GLU CB    HB2    sing N N 203 
GLU CB    HB3    sing N N 204 
GLU CG    CD     sing N N 205 
GLU CG    HG2    sing N N 206 
GLU CG    HG3    sing N N 207 
GLU CD    OE1    doub N N 208 
GLU CD    OE2    sing N N 209 
GLU OE2   HE2    sing N N 210 
GLU OXT   HXT    sing N N 211 
GLY N     CA     sing N N 212 
GLY N     H      sing N N 213 
GLY N     H2     sing N N 214 
GLY CA    C      sing N N 215 
GLY CA    HA2    sing N N 216 
GLY CA    HA3    sing N N 217 
GLY C     O      doub N N 218 
GLY C     OXT    sing N N 219 
GLY OXT   HXT    sing N N 220 
HEZ O1    C1     sing N N 221 
HEZ O1    HO1    sing N N 222 
HEZ C1    C2     sing N N 223 
HEZ C1    H11    sing N N 224 
HEZ C1    H12    sing N N 225 
HEZ C2    C3     sing N N 226 
HEZ C2    H21    sing N N 227 
HEZ C2    H22    sing N N 228 
HEZ C3    C4     sing N N 229 
HEZ C3    H31    sing N N 230 
HEZ C3    H32    sing N N 231 
HEZ C4    C5     sing N N 232 
HEZ C4    H41    sing N N 233 
HEZ C4    H42    sing N N 234 
HEZ C5    C6     sing N N 235 
HEZ C5    H51    sing N N 236 
HEZ C5    H52    sing N N 237 
HEZ C6    O6     sing N N 238 
HEZ C6    H61    sing N N 239 
HEZ C6    H62    sing N N 240 
HEZ O6    HO6    sing N N 241 
HIS N     CA     sing N N 242 
HIS N     H      sing N N 243 
HIS N     H2     sing N N 244 
HIS CA    C      sing N N 245 
HIS CA    CB     sing N N 246 
HIS CA    HA     sing N N 247 
HIS C     O      doub N N 248 
HIS C     OXT    sing N N 249 
HIS CB    CG     sing N N 250 
HIS CB    HB2    sing N N 251 
HIS CB    HB3    sing N N 252 
HIS CG    ND1    sing Y N 253 
HIS CG    CD2    doub Y N 254 
HIS ND1   CE1    doub Y N 255 
HIS ND1   HD1    sing N N 256 
HIS CD2   NE2    sing Y N 257 
HIS CD2   HD2    sing N N 258 
HIS CE1   NE2    sing Y N 259 
HIS CE1   HE1    sing N N 260 
HIS NE2   HE2    sing N N 261 
HIS OXT   HXT    sing N N 262 
HOH O     H1     sing N N 263 
HOH O     H2     sing N N 264 
ILE N     CA     sing N N 265 
ILE N     H      sing N N 266 
ILE N     H2     sing N N 267 
ILE CA    C      sing N N 268 
ILE CA    CB     sing N N 269 
ILE CA    HA     sing N N 270 
ILE C     O      doub N N 271 
ILE C     OXT    sing N N 272 
ILE CB    CG1    sing N N 273 
ILE CB    CG2    sing N N 274 
ILE CB    HB     sing N N 275 
ILE CG1   CD1    sing N N 276 
ILE CG1   HG12   sing N N 277 
ILE CG1   HG13   sing N N 278 
ILE CG2   HG21   sing N N 279 
ILE CG2   HG22   sing N N 280 
ILE CG2   HG23   sing N N 281 
ILE CD1   HD11   sing N N 282 
ILE CD1   HD12   sing N N 283 
ILE CD1   HD13   sing N N 284 
ILE OXT   HXT    sing N N 285 
LEU N     CA     sing N N 286 
LEU N     H      sing N N 287 
LEU N     H2     sing N N 288 
LEU CA    C      sing N N 289 
LEU CA    CB     sing N N 290 
LEU CA    HA     sing N N 291 
LEU C     O      doub N N 292 
LEU C     OXT    sing N N 293 
LEU CB    CG     sing N N 294 
LEU CB    HB2    sing N N 295 
LEU CB    HB3    sing N N 296 
LEU CG    CD1    sing N N 297 
LEU CG    CD2    sing N N 298 
LEU CG    HG     sing N N 299 
LEU CD1   HD11   sing N N 300 
LEU CD1   HD12   sing N N 301 
LEU CD1   HD13   sing N N 302 
LEU CD2   HD21   sing N N 303 
LEU CD2   HD22   sing N N 304 
LEU CD2   HD23   sing N N 305 
LEU OXT   HXT    sing N N 306 
LYS N     CA     sing N N 307 
LYS N     H      sing N N 308 
LYS N     H2     sing N N 309 
LYS CA    C      sing N N 310 
LYS CA    CB     sing N N 311 
LYS CA    HA     sing N N 312 
LYS C     O      doub N N 313 
LYS C     OXT    sing N N 314 
LYS CB    CG     sing N N 315 
LYS CB    HB2    sing N N 316 
LYS CB    HB3    sing N N 317 
LYS CG    CD     sing N N 318 
LYS CG    HG2    sing N N 319 
LYS CG    HG3    sing N N 320 
LYS CD    CE     sing N N 321 
LYS CD    HD2    sing N N 322 
LYS CD    HD3    sing N N 323 
LYS CE    NZ     sing N N 324 
LYS CE    HE2    sing N N 325 
LYS CE    HE3    sing N N 326 
LYS NZ    HZ1    sing N N 327 
LYS NZ    HZ2    sing N N 328 
LYS NZ    HZ3    sing N N 329 
LYS OXT   HXT    sing N N 330 
MET N     CA     sing N N 331 
MET N     H      sing N N 332 
MET N     H2     sing N N 333 
MET CA    C      sing N N 334 
MET CA    CB     sing N N 335 
MET CA    HA     sing N N 336 
MET C     O      doub N N 337 
MET C     OXT    sing N N 338 
MET CB    CG     sing N N 339 
MET CB    HB2    sing N N 340 
MET CB    HB3    sing N N 341 
MET CG    SD     sing N N 342 
MET CG    HG2    sing N N 343 
MET CG    HG3    sing N N 344 
MET SD    CE     sing N N 345 
MET CE    HE1    sing N N 346 
MET CE    HE2    sing N N 347 
MET CE    HE3    sing N N 348 
MET OXT   HXT    sing N N 349 
PHE N     CA     sing N N 350 
PHE N     H      sing N N 351 
PHE N     H2     sing N N 352 
PHE CA    C      sing N N 353 
PHE CA    CB     sing N N 354 
PHE CA    HA     sing N N 355 
PHE C     O      doub N N 356 
PHE C     OXT    sing N N 357 
PHE CB    CG     sing N N 358 
PHE CB    HB2    sing N N 359 
PHE CB    HB3    sing N N 360 
PHE CG    CD1    doub Y N 361 
PHE CG    CD2    sing Y N 362 
PHE CD1   CE1    sing Y N 363 
PHE CD1   HD1    sing N N 364 
PHE CD2   CE2    doub Y N 365 
PHE CD2   HD2    sing N N 366 
PHE CE1   CZ     doub Y N 367 
PHE CE1   HE1    sing N N 368 
PHE CE2   CZ     sing Y N 369 
PHE CE2   HE2    sing N N 370 
PHE CZ    HZ     sing N N 371 
PHE OXT   HXT    sing N N 372 
PRO N     CA     sing N N 373 
PRO N     CD     sing N N 374 
PRO N     H      sing N N 375 
PRO CA    C      sing N N 376 
PRO CA    CB     sing N N 377 
PRO CA    HA     sing N N 378 
PRO C     O      doub N N 379 
PRO C     OXT    sing N N 380 
PRO CB    CG     sing N N 381 
PRO CB    HB2    sing N N 382 
PRO CB    HB3    sing N N 383 
PRO CG    CD     sing N N 384 
PRO CG    HG2    sing N N 385 
PRO CG    HG3    sing N N 386 
PRO CD    HD2    sing N N 387 
PRO CD    HD3    sing N N 388 
PRO OXT   HXT    sing N N 389 
SER N     CA     sing N N 390 
SER N     H      sing N N 391 
SER N     H2     sing N N 392 
SER CA    C      sing N N 393 
SER CA    CB     sing N N 394 
SER CA    HA     sing N N 395 
SER C     O      doub N N 396 
SER C     OXT    sing N N 397 
SER CB    OG     sing N N 398 
SER CB    HB2    sing N N 399 
SER CB    HB3    sing N N 400 
SER OG    HG     sing N N 401 
SER OXT   HXT    sing N N 402 
THR N     CA     sing N N 403 
THR N     H      sing N N 404 
THR N     H2     sing N N 405 
THR CA    C      sing N N 406 
THR CA    CB     sing N N 407 
THR CA    HA     sing N N 408 
THR C     O      doub N N 409 
THR C     OXT    sing N N 410 
THR CB    OG1    sing N N 411 
THR CB    CG2    sing N N 412 
THR CB    HB     sing N N 413 
THR OG1   HG1    sing N N 414 
THR CG2   HG21   sing N N 415 
THR CG2   HG22   sing N N 416 
THR CG2   HG23   sing N N 417 
THR OXT   HXT    sing N N 418 
TRP N     CA     sing N N 419 
TRP N     H      sing N N 420 
TRP N     H2     sing N N 421 
TRP CA    C      sing N N 422 
TRP CA    CB     sing N N 423 
TRP CA    HA     sing N N 424 
TRP C     O      doub N N 425 
TRP C     OXT    sing N N 426 
TRP CB    CG     sing N N 427 
TRP CB    HB2    sing N N 428 
TRP CB    HB3    sing N N 429 
TRP CG    CD1    doub Y N 430 
TRP CG    CD2    sing Y N 431 
TRP CD1   NE1    sing Y N 432 
TRP CD1   HD1    sing N N 433 
TRP CD2   CE2    doub Y N 434 
TRP CD2   CE3    sing Y N 435 
TRP NE1   CE2    sing Y N 436 
TRP NE1   HE1    sing N N 437 
TRP CE2   CZ2    sing Y N 438 
TRP CE3   CZ3    doub Y N 439 
TRP CE3   HE3    sing N N 440 
TRP CZ2   CH2    doub Y N 441 
TRP CZ2   HZ2    sing N N 442 
TRP CZ3   CH2    sing Y N 443 
TRP CZ3   HZ3    sing N N 444 
TRP CH2   HH2    sing N N 445 
TRP OXT   HXT    sing N N 446 
TYR N     CA     sing N N 447 
TYR N     H      sing N N 448 
TYR N     H2     sing N N 449 
TYR CA    C      sing N N 450 
TYR CA    CB     sing N N 451 
TYR CA    HA     sing N N 452 
TYR C     O      doub N N 453 
TYR C     OXT    sing N N 454 
TYR CB    CG     sing N N 455 
TYR CB    HB2    sing N N 456 
TYR CB    HB3    sing N N 457 
TYR CG    CD1    doub Y N 458 
TYR CG    CD2    sing Y N 459 
TYR CD1   CE1    sing Y N 460 
TYR CD1   HD1    sing N N 461 
TYR CD2   CE2    doub Y N 462 
TYR CD2   HD2    sing N N 463 
TYR CE1   CZ     doub Y N 464 
TYR CE1   HE1    sing N N 465 
TYR CE2   CZ     sing Y N 466 
TYR CE2   HE2    sing N N 467 
TYR CZ    OH     sing N N 468 
TYR OH    HH     sing N N 469 
TYR OXT   HXT    sing N N 470 
VAL N     CA     sing N N 471 
VAL N     H      sing N N 472 
VAL N     H2     sing N N 473 
VAL CA    C      sing N N 474 
VAL CA    CB     sing N N 475 
VAL CA    HA     sing N N 476 
VAL C     O      doub N N 477 
VAL C     OXT    sing N N 478 
VAL CB    CG1    sing N N 479 
VAL CB    CG2    sing N N 480 
VAL CB    HB     sing N N 481 
VAL CG1   HG11   sing N N 482 
VAL CG1   HG12   sing N N 483 
VAL CG1   HG13   sing N N 484 
VAL CG2   HG21   sing N N 485 
VAL CG2   HG22   sing N N 486 
VAL CG2   HG23   sing N N 487 
VAL OXT   HXT    sing N N 488 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Ministerio de Ciencia e Innovacion (MCIN)' Spain TED2021-130803B-I00            1 
'Other government'                          ?     'Biologia Estructural E35_23R' 2 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'in silico model' 
_pdbx_initial_refinement_model.source_name      AlphaFold 
_pdbx_initial_refinement_model.accession_code   AF-A0A4U9JHU9-F1-model_v4 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8RPF 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.012197 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.001791 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.013024 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.011457 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.pdbx_scat_Z 
_atom_type.pdbx_N_electrons 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
C 6  6  2.3103  20.8439 1.0201 10.2075 1.5888 0.5687  0.8651 51.6512 0.2156   
H 1  1  0.4930  10.5109 0.3229 26.1257 0.1402 3.1424  0.0408 57.7997 0.0030   
N 7  7  12.2220 0.0057  3.1346 9.8933  2.0141 28.9975 1.1672 0.5826  -11.5379 
O 8  8  3.0487  13.2771 2.2870 5.7011  1.5464 0.3239  0.8671 32.9089 0.2508   
P 15 15 6.4348  1.9067  4.1793 27.1570 1.7801 0.5260  1.4909 68.1645 1.2678   
S 16 16 6.9054  1.4679  5.2035 22.2151 1.4379 0.2536  1.5863 56.1720 1.0495   
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
_atom_site.calc_flag 
ATOM   1    N N     . LYS A 1 22  ? 9.969   32.886  21.324 1.00 67.89  ? 1    LYS A N     1 ? 
ATOM   2    C CA    . LYS A 1 22  ? 8.631   32.520  20.780 1.00 66.33  ? 1    LYS A CA    1 ? 
ATOM   3    C C     . LYS A 1 22  ? 7.663   32.335  21.946 1.00 61.47  ? 1    LYS A C     1 ? 
ATOM   4    O O     . LYS A 1 22  ? 8.082   31.868  23.006 1.00 61.52  ? 1    LYS A O     1 ? 
ATOM   5    C CB    . LYS A 1 22  ? 8.734   31.250  19.931 1.00 66.73  ? 1    LYS A CB    1 ? 
ATOM   6    C CG    . LYS A 1 22  ? 9.867   31.247  18.907 1.00 70.66  ? 1    LYS A CG    1 ? 
ATOM   7    C CD    . LYS A 1 22  ? 9.908   30.012  18.014 1.00 70.28  ? 1    LYS A CD    1 ? 
ATOM   8    C CE    . LYS A 1 22  ? 8.734   29.942  17.095 1.00 71.30  ? 1    LYS A CE    1 ? 
ATOM   9    N NZ    . LYS A 1 22  ? 8.582   31.125  16.247 1.00 70.22  ? 1    LYS A NZ    1 ? 
ATOM   10   N N     . LYS A 1 23  ? 6.385   32.710  21.736 1.00 57.43  ? 2    LYS A N     1 ? 
ATOM   11   C CA    . LYS A 1 23  ? 5.366   32.681  22.779 1.00 53.25  ? 2    LYS A CA    1 ? 
ATOM   12   C C     . LYS A 1 23  ? 4.307   31.627  22.449 1.00 44.21  ? 2    LYS A C     1 ? 
ATOM   13   O O     . LYS A 1 23  ? 3.674   31.692  21.401 1.00 52.22  ? 2    LYS A O     1 ? 
ATOM   14   C CB    . LYS A 1 23  ? 4.709   34.059  22.876 1.00 64.44  ? 2    LYS A CB    1 ? 
ATOM   15   C CG    . LYS A 1 23  ? 3.892   34.271  24.140 1.00 81.08  ? 2    LYS A CG    1 ? 
ATOM   16   C CD    . LYS A 1 23  ? 2.728   35.243  23.983 1.00 92.47  ? 2    LYS A CD    1 ? 
ATOM   17   C CE    . LYS A 1 23  ? 1.731   35.102  25.094 1.00 96.81  ? 2    LYS A CE    1 ? 
ATOM   18   N NZ    . LYS A 1 23  ? 0.499   35.843  24.814 1.00 96.22  ? 2    LYS A NZ    1 ? 
ATOM   19   N N     . PHE A 1 24  ? 4.091   30.667  23.352 1.00 37.34  ? 3    PHE A N     1 ? 
ATOM   20   C CA    . PHE A 1 24  ? 3.256   29.514  23.029 1.00 32.57  ? 3    PHE A CA    1 ? 
ATOM   21   C C     . PHE A 1 24  ? 1.915   29.593  23.735 1.00 27.08  ? 3    PHE A C     1 ? 
ATOM   22   O O     . PHE A 1 24  ? 1.834   29.977  24.899 1.00 32.77  ? 3    PHE A O     1 ? 
ATOM   23   C CB    . PHE A 1 24  ? 3.970   28.196  23.374 1.00 31.38  ? 3    PHE A CB    1 ? 
ATOM   24   C CG    . PHE A 1 24  ? 5.287   28.076  22.635 1.00 30.05  ? 3    PHE A CG    1 ? 
ATOM   25   C CD1   . PHE A 1 24  ? 5.312   27.863  21.266 1.00 32.76  ? 3    PHE A CD1   1 ? 
ATOM   26   C CD2   . PHE A 1 24  ? 6.490   28.209  23.313 1.00 33.35  ? 3    PHE A CD2   1 ? 
ATOM   27   C CE1   . PHE A 1 24  ? 6.518   27.795  20.588 1.00 32.67  ? 3    PHE A CE1   1 ? 
ATOM   28   C CE2   . PHE A 1 24  ? 7.692   28.145  22.628 1.00 34.65  ? 3    PHE A CE2   1 ? 
ATOM   29   C CZ    . PHE A 1 24  ? 7.702   27.936  21.277 1.00 32.26  ? 3    PHE A CZ    1 ? 
ATOM   30   N N     . ASP A 1 25  ? 0.875   29.157  23.023 1.00 27.44  ? 4    ASP A N     1 ? 
ATOM   31   C CA    . ASP A 1 25  ? -0.448  28.967  23.593 1.00 27.30  ? 4    ASP A CA    1 ? 
ATOM   32   C C     . ASP A 1 25  ? -0.544  27.600  24.285 1.00 28.39  ? 4    ASP A C     1 ? 
ATOM   33   O O     . ASP A 1 25  ? -1.126  27.481  25.371 1.00 27.33  ? 4    ASP A O     1 ? 
ATOM   34   C CB    . ASP A 1 25  ? -1.464  29.085  22.471 1.00 30.59  ? 4    ASP A CB    1 ? 
ATOM   35   C CG    . ASP A 1 25  ? -1.582  30.496  21.915 1.00 32.73  ? 4    ASP A CG    1 ? 
ATOM   36   O OD1   . ASP A 1 25  ? -2.128  31.315  22.659 1.00 31.34  ? 4    ASP A OD1   1 ? 
ATOM   37   O OD2   . ASP A 1 25  ? -1.065  30.752  20.808 1.00 35.50  ? 4    ASP A OD2   1 ? 
ATOM   38   N N     . PHE A 1 26  ? 0.072   26.596  23.653 1.00 24.83  ? 5    PHE A N     1 ? 
ATOM   39   C CA    . PHE A 1 26  ? 0.021   25.216  24.104 1.00 25.59  ? 5    PHE A CA    1 ? 
ATOM   40   C C     . PHE A 1 26  ? 1.416   24.596  24.077 1.00 23.55  ? 5    PHE A C     1 ? 
ATOM   41   O O     . PHE A 1 26  ? 2.174   24.795  23.147 1.00 26.07  ? 5    PHE A O     1 ? 
ATOM   42   C CB    . PHE A 1 26  ? -0.880  24.364  23.194 1.00 24.50  ? 5    PHE A CB    1 ? 
ATOM   43   C CG    . PHE A 1 26  ? -2.343  24.782  23.242 1.00 26.26  ? 5    PHE A CG    1 ? 
ATOM   44   C CD1   . PHE A 1 26  ? -3.196  24.304  24.231 1.00 26.40  ? 5    PHE A CD1   1 ? 
ATOM   45   C CD2   . PHE A 1 26  ? -2.863  25.642  22.275 1.00 28.61  ? 5    PHE A CD2   1 ? 
ATOM   46   C CE1   . PHE A 1 26  ? -4.535  24.677  24.247 1.00 29.91  ? 5    PHE A CE1   1 ? 
ATOM   47   C CE2   . PHE A 1 26  ? -4.187  26.032  22.312 1.00 27.43  ? 5    PHE A CE2   1 ? 
ATOM   48   C CZ    . PHE A 1 26  ? -5.020  25.553  23.293 1.00 31.64  ? 5    PHE A CZ    1 ? 
ATOM   49   N N     . ILE A 1 27  ? 1.703   23.774  25.083 1.00 22.11  ? 6    ILE A N     1 ? 
ATOM   50   C CA    . ILE A 1 27  ? 2.837   22.870  25.049 1.00 22.27  ? 6    ILE A CA    1 ? 
ATOM   51   C C     . ILE A 1 27  ? 2.290   21.442  25.120 1.00 22.00  ? 6    ILE A C     1 ? 
ATOM   52   O O     . ILE A 1 27  ? 1.521   21.134  26.042 1.00 20.87  ? 6    ILE A O     1 ? 
ATOM   53   C CB    . ILE A 1 27  ? 3.805   23.151  26.211 1.00 21.80  ? 6    ILE A CB    1 ? 
ATOM   54   C CG1   . ILE A 1 27  ? 4.441   24.548  26.120 1.00 22.66  ? 6    ILE A CG1   1 ? 
ATOM   55   C CG2   . ILE A 1 27  ? 4.892   22.065  26.277 1.00 21.45  ? 6    ILE A CG2   1 ? 
ATOM   56   C CD1   . ILE A 1 27  ? 5.252   24.915  27.347 1.00 24.72  ? 6    ILE A CD1   1 ? 
ATOM   57   N N     . ILE A 1 28  ? 2.695   20.618  24.148 1.00 23.15  ? 7    ILE A N     1 ? 
ATOM   58   C CA    . ILE A 1 28  ? 2.360   19.208  24.113 1.00 22.64  ? 7    ILE A CA    1 ? 
ATOM   59   C C     . ILE A 1 28  ? 3.604   18.387  24.459 1.00 20.41  ? 7    ILE A C     1 ? 
ATOM   60   O O     . ILE A 1 28  ? 4.651   18.545  23.846 1.00 22.81  ? 7    ILE A O     1 ? 
ATOM   61   C CB    . ILE A 1 28  ? 1.767   18.803  22.753 1.00 22.14  ? 7    ILE A CB    1 ? 
ATOM   62   C CG1   . ILE A 1 28  ? 0.496   19.609  22.434 1.00 23.37  ? 7    ILE A CG1   1 ? 
ATOM   63   C CG2   . ILE A 1 28  ? 1.534   17.287  22.709 1.00 22.05  ? 7    ILE A CG2   1 ? 
ATOM   64   C CD1   . ILE A 1 28  ? 0.113   19.598  20.975 1.00 23.21  ? 7    ILE A CD1   1 ? 
ATOM   65   N N     . VAL A 1 29  ? 3.485   17.539  25.473 1.00 18.72  ? 8    VAL A N     1 ? 
ATOM   66   C CA    . VAL A 1 29  ? 4.581   16.689  25.902 1.00 19.43  ? 8    VAL A CA    1 ? 
ATOM   67   C C     . VAL A 1 29  ? 4.417   15.296  25.295 1.00 21.30  ? 8    VAL A C     1 ? 
ATOM   68   O O     . VAL A 1 29  ? 3.535   14.546  25.720 1.00 20.94  ? 8    VAL A O     1 ? 
ATOM   69   C CB    . VAL A 1 29  ? 4.661   16.625  27.434 1.00 19.80  ? 8    VAL A CB    1 ? 
ATOM   70   C CG1   . VAL A 1 29  ? 5.767   15.682  27.933 1.00 20.53  ? 8    VAL A CG1   1 ? 
ATOM   71   C CG2   . VAL A 1 29  ? 4.820   17.996  28.056 1.00 20.40  ? 8    VAL A CG2   1 ? 
ATOM   72   N N     . GLY A 1 30  ? 5.315   14.959  24.357 1.00 19.64  ? 9    GLY A N     1 ? 
ATOM   73   C CA    . GLY A 1 30  ? 5.380   13.655  23.726 1.00 21.40  ? 9    GLY A CA    1 ? 
ATOM   74   C C     . GLY A 1 30  ? 4.870   13.697  22.290 1.00 21.97  ? 9    GLY A C     1 ? 
ATOM   75   O O     . GLY A 1 30  ? 3.670   13.849  22.047 1.00 20.35  ? 9    GLY A O     1 ? 
ATOM   76   N N     . ALA A 1 31  ? 5.789   13.514  21.339 1.00 21.14  ? 10   ALA A N     1 ? 
ATOM   77   C CA    . ALA A 1 31  ? 5.441   13.446  19.927 1.00 22.82  ? 10   ALA A CA    1 ? 
ATOM   78   C C     . ALA A 1 31  ? 5.344   11.985  19.519 1.00 21.37  ? 10   ALA A C     1 ? 
ATOM   79   O O     . ALA A 1 31  ? 6.045   11.498  18.623 1.00 21.77  ? 10   ALA A O     1 ? 
ATOM   80   C CB    . ALA A 1 31  ? 6.465   14.201  19.098 1.00 23.43  ? 10   ALA A CB    1 ? 
ATOM   81   N N     . GLY A 1 32  ? 4.476   11.251  20.226 1.00 21.81  ? 11   GLY A N     1 ? 
ATOM   82   C CA    . GLY A 1 32  ? 4.354   9.820   20.000 1.00 18.05  ? 11   GLY A CA    1 ? 
ATOM   83   C C     . GLY A 1 32  ? 3.263   9.509   18.978 1.00 19.17  ? 11   GLY A C     1 ? 
ATOM   84   O O     . GLY A 1 32  ? 3.426   9.733   17.768 1.00 18.22  ? 11   GLY A O     1 ? 
ATOM   85   N N     . THR A 1 33  ? 2.168   8.926   19.468 1.00 18.47  ? 12   THR A N     1 ? 
ATOM   86   C CA    . THR A 1 33  ? 1.051   8.552   18.611 1.00 19.11  ? 12   THR A CA    1 ? 
ATOM   87   C C     . THR A 1 33  ? -0.016  9.648   18.630 1.00 20.04  ? 12   THR A C     1 ? 
ATOM   88   O O     . THR A 1 33  ? -0.419  10.116  17.575 1.00 22.99  ? 12   THR A O     1 ? 
ATOM   89   C CB    . THR A 1 33  ? 0.564   7.173   19.049 1.00 20.88  ? 12   THR A CB    1 ? 
ATOM   90   O OG1   . THR A 1 33  ? 1.655   6.256   19.145 1.00 19.44  ? 12   THR A OG1   1 ? 
ATOM   91   C CG2   . THR A 1 33  ? -0.451  6.603   18.084 1.00 23.21  ? 12   THR A CG2   1 ? 
ATOM   92   N N     . ALA A 1 34  ? -0.530  9.996   19.815 1.00 20.35  ? 13   ALA A N     1 ? 
ATOM   93   C CA    . ALA A 1 34  ? -1.552  11.026  19.971 1.00 19.75  ? 13   ALA A CA    1 ? 
ATOM   94   C C     . ALA A 1 34  ? -0.989  12.447  19.852 1.00 20.92  ? 13   ALA A C     1 ? 
ATOM   95   O O     . ALA A 1 34  ? -1.626  13.321  19.260 1.00 21.43  ? 13   ALA A O     1 ? 
ATOM   96   C CB    . ALA A 1 34  ? -2.220  10.881  21.312 1.00 20.50  ? 13   ALA A CB    1 ? 
ATOM   97   N N     . GLY A 1 35  ? 0.156   12.713  20.490 1.00 19.29  ? 14   GLY A N     1 ? 
ATOM   98   C CA    . GLY A 1 35  ? 0.663   14.075  20.595 1.00 20.76  ? 14   GLY A CA    1 ? 
ATOM   99   C C     . GLY A 1 35  ? 0.765   14.738  19.216 1.00 23.40  ? 14   GLY A C     1 ? 
ATOM   100  O O     . GLY A 1 35  ? 0.362   15.907  19.046 1.00 23.53  ? 14   GLY A O     1 ? 
ATOM   101  N N     . PRO A 1 36  ? 1.350   14.044  18.212 1.00 21.67  ? 15   PRO A N     1 ? 
ATOM   102  C CA    . PRO A 1 36  ? 1.500   14.606  16.862 1.00 23.59  ? 15   PRO A CA    1 ? 
ATOM   103  C C     . PRO A 1 36  ? 0.212   15.014  16.167 1.00 27.81  ? 15   PRO A C     1 ? 
ATOM   104  O O     . PRO A 1 36  ? 0.196   16.015  15.452 1.00 23.46  ? 15   PRO A O     1 ? 
ATOM   105  C CB    . PRO A 1 36  ? 2.255   13.492  16.103 1.00 23.39  ? 15   PRO A CB    1 ? 
ATOM   106  C CG    . PRO A 1 36  ? 3.102   12.883  17.206 1.00 23.30  ? 15   PRO A CG    1 ? 
ATOM   107  C CD    . PRO A 1 36  ? 2.103   12.787  18.355 1.00 21.91  ? 15   PRO A CD    1 ? 
ATOM   108  N N     . VAL A 1 37  ? -0.851  14.237  16.404 1.00 25.59  ? 16   VAL A N     1 ? 
ATOM   109  C CA    . VAL A 1 37  ? -2.164  14.535  15.878 1.00 27.77  ? 16   VAL A CA    1 ? 
ATOM   110  C C     . VAL A 1 37  ? -2.602  15.908  16.374 1.00 27.62  ? 16   VAL A C     1 ? 
ATOM   111  O O     . VAL A 1 37  ? -3.069  16.741  15.577 1.00 26.72  ? 16   VAL A O     1 ? 
ATOM   112  C CB    . VAL A 1 37  ? -3.211  13.469  16.257 1.00 23.51  ? 16   VAL A CB    1 ? 
ATOM   113  C CG1   . VAL A 1 37  ? -4.582  13.874  15.752 1.00 25.83  ? 16   VAL A CG1   1 ? 
ATOM   114  C CG2   . VAL A 1 37  ? -2.826  12.106  15.739 1.00 23.52  ? 16   VAL A CG2   1 ? 
ATOM   115  N N     . ILE A 1 38  ? -2.436  16.113  17.687 1.00 23.53  ? 17   ILE A N     1 ? 
ATOM   116  C CA    . ILE A 1 38  ? -2.918  17.308  18.338 1.00 23.85  ? 17   ILE A CA    1 ? 
ATOM   117  C C     . ILE A 1 38  ? -2.106  18.519  17.877 1.00 26.94  ? 17   ILE A C     1 ? 
ATOM   118  O O     . ILE A 1 38  ? -2.679  19.591  17.657 1.00 25.35  ? 17   ILE A O     1 ? 
ATOM   119  C CB    . ILE A 1 38  ? -2.889  17.155  19.861 1.00 22.87  ? 17   ILE A CB    1 ? 
ATOM   120  C CG1   . ILE A 1 38  ? -3.733  15.950  20.308 1.00 22.09  ? 17   ILE A CG1   1 ? 
ATOM   121  C CG2   . ILE A 1 38  ? -3.330  18.442  20.546 1.00 24.36  ? 17   ILE A CG2   1 ? 
ATOM   122  C CD1   . ILE A 1 38  ? -3.568  15.620  21.773 1.00 21.79  ? 17   ILE A CD1   1 ? 
ATOM   123  N N     . ALA A 1 39  ? -0.781  18.358  17.776 1.00 25.76  ? 18   ALA A N     1 ? 
ATOM   124  C CA    . ALA A 1 39  ? 0.065   19.456  17.322 1.00 27.28  ? 18   ALA A CA    1 ? 
ATOM   125  C C     . ALA A 1 39  ? -0.308  19.879  15.895 1.00 29.77  ? 18   ALA A C     1 ? 
ATOM   126  O O     . ALA A 1 39  ? -0.280  21.072  15.567 1.00 28.86  ? 18   ALA A O     1 ? 
ATOM   127  C CB    . ALA A 1 39  ? 1.510   19.085  17.445 1.00 23.31  ? 18   ALA A CB    1 ? 
ATOM   128  N N     . SER A 1 40  ? -0.643  18.892  15.059 1.00 26.32  ? 19   SER A N     1 ? 
ATOM   129  C CA    . SER A 1 40  ? -0.983  19.111  13.663 1.00 27.78  ? 19   SER A CA    1 ? 
ATOM   130  C C     . SER A 1 40  ? -2.312  19.863  13.542 1.00 33.06  ? 19   SER A C     1 ? 
ATOM   131  O O     . SER A 1 40  ? -2.406  20.843  12.789 1.00 31.03  ? 19   SER A O     1 ? 
ATOM   132  C CB    . SER A 1 40  ? -1.028  17.810  12.930 1.00 26.06  ? 19   SER A CB    1 ? 
ATOM   133  O OG    . SER A 1 40  ? -1.256  17.975  11.543 1.00 25.38  ? 19   SER A OG    1 ? 
ATOM   134  N N     . ARG A 1 41  ? -3.321  19.416  14.308 1.00 27.71  ? 20   ARG A N     1 ? 
ATOM   135  C CA    . ARG A 1 41  ? -4.661  19.970  14.246 1.00 28.02  ? 20   ARG A CA    1 ? 
ATOM   136  C C     . ARG A 1 41  ? -4.693  21.364  14.864 1.00 29.61  ? 20   ARG A C     1 ? 
ATOM   137  O O     . ARG A 1 41  ? -5.335  22.255  14.318 1.00 28.46  ? 20   ARG A O     1 ? 
ATOM   138  C CB    . ARG A 1 41  ? -5.718  19.070  14.908 1.00 29.24  ? 20   ARG A CB    1 ? 
ATOM   139  C CG    . ARG A 1 41  ? -5.996  17.741  14.225 1.00 28.60  ? 20   ARG A CG    1 ? 
ATOM   140  C CD    . ARG A 1 41  ? -6.279  17.841  12.714 1.00 28.37  ? 20   ARG A CD    1 ? 
ATOM   141  N NE    . ARG A 1 41  ? -6.782  16.581  12.160 1.00 26.66  ? 20   ARG A NE    1 ? 
ATOM   142  C CZ    . ARG A 1 41  ? -7.006  16.361  10.872 1.00 31.45  ? 20   ARG A CZ    1 ? 
ATOM   143  N NH1   . ARG A 1 41  ? -6.870  17.347  9.994  1.00 33.39  ? 20   ARG A NH1   1 ? 
ATOM   144  N NH2   . ARG A 1 41  ? -7.377  15.180  10.453 1.00 30.22  ? 20   ARG A NH2   1 ? 
ATOM   145  N N     . LEU A 1 42  ? -4.029  21.567  16.003 1.00 24.69  ? 21   LEU A N     1 ? 
ATOM   146  C CA    . LEU A 1 42  ? -4.136  22.839  16.685 1.00 28.52  ? 21   LEU A CA    1 ? 
ATOM   147  C C     . LEU A 1 42  ? -3.458  23.961  15.885 1.00 31.82  ? 21   LEU A C     1 ? 
ATOM   148  O O     . LEU A 1 42  ? -3.780  25.115  16.112 1.00 34.43  ? 21   LEU A O     1 ? 
ATOM   149  C CB    . LEU A 1 42  ? -3.509  22.764  18.074 1.00 26.03  ? 21   LEU A CB    1 ? 
ATOM   150  C CG    . LEU A 1 42  ? -4.233  21.939  19.142 1.00 26.68  ? 21   LEU A CG    1 ? 
ATOM   151  C CD1   . LEU A 1 42  ? -3.572  22.204  20.499 1.00 27.26  ? 21   LEU A CD1   1 ? 
ATOM   152  C CD2   . LEU A 1 42  ? -5.728  22.208  19.218 1.00 28.84  ? 21   LEU A CD2   1 ? 
ATOM   153  N N     . THR A 1 43  ? -2.460  23.649  15.048 1.00 33.35  ? 22   THR A N     1 ? 
ATOM   154  C CA    . THR A 1 43  ? -1.726  24.687  14.334 1.00 32.76  ? 22   THR A CA    1 ? 
ATOM   155  C C     . THR A 1 43  ? -2.378  24.973  12.978 1.00 37.20  ? 22   THR A C     1 ? 
ATOM   156  O O     . THR A 1 43  ? -1.872  25.789  12.220 1.00 37.24  ? 22   THR A O     1 ? 
ATOM   157  C CB    . THR A 1 43  ? -0.242  24.343  14.193 1.00 28.23  ? 22   THR A CB    1 ? 
ATOM   158  O OG1   . THR A 1 43  ? -0.098  23.112  13.505 1.00 27.06  ? 22   THR A OG1   1 ? 
ATOM   159  C CG2   . THR A 1 43  ? 0.480   24.330  15.525 1.00 31.62  ? 22   THR A CG2   1 ? 
ATOM   160  N N     . GLU A 1 44  ? -3.504  24.316  12.677 1.00 37.58  ? 23   GLU A N     1 ? 
ATOM   161  C CA    . GLU A 1 44  ? -4.324  24.687  11.532 1.00 40.99  ? 23   GLU A CA    1 ? 
ATOM   162  C C     . GLU A 1 44  ? -4.864  26.110  11.699 1.00 42.25  ? 23   GLU A C     1 ? 
ATOM   163  O O     . GLU A 1 44  ? -5.098  26.774  10.704 1.00 49.46  ? 23   GLU A O     1 ? 
ATOM   164  C CB    . GLU A 1 44  ? -5.458  23.693  11.278 1.00 36.20  ? 23   GLU A CB    1 ? 
ATOM   165  C CG    . GLU A 1 44  ? -4.946  22.359  10.752 1.00 36.27  ? 23   GLU A CG    1 ? 
ATOM   166  C CD    . GLU A 1 44  ? -5.984  21.252  10.659 1.00 36.22  ? 23   GLU A CD    1 ? 
ATOM   167  O OE1   . GLU A 1 44  ? -5.648  20.097  10.320 1.00 33.02  ? 23   GLU A OE1   1 ? 
ATOM   168  O OE2   . GLU A 1 44  ? -7.148  21.544  10.922 1.00 34.69  ? 23   GLU A OE2   1 ? 
ATOM   169  N N     . LYS A 1 45  ? -5.043  26.590  12.932 1.00 43.99  ? 24   LYS A N     1 ? 
ATOM   170  C CA    . LYS A 1 45  ? -5.346  27.999  13.165 1.00 46.35  ? 24   LYS A CA    1 ? 
ATOM   171  C C     . LYS A 1 45  ? -4.040  28.779  13.317 1.00 47.59  ? 24   LYS A C     1 ? 
ATOM   172  O O     . LYS A 1 45  ? -3.247  28.479  14.210 1.00 36.92  ? 24   LYS A O     1 ? 
ATOM   173  C CB    . LYS A 1 45  ? -6.210  28.204  14.411 1.00 47.78  ? 24   LYS A CB    1 ? 
ATOM   174  C CG    . LYS A 1 45  ? -7.441  27.324  14.527 1.00 55.32  ? 24   LYS A CG    1 ? 
ATOM   175  C CD    . LYS A 1 45  ? -8.772  27.774  13.934 1.00 61.19  ? 24   LYS A CD    1 ? 
ATOM   176  C CE    . LYS A 1 45  ? -9.739  26.615  13.992 1.00 64.88  ? 24   LYS A CE    1 ? 
ATOM   177  N NZ    . LYS A 1 45  ? -11.130 26.971  13.700 1.00 64.87  ? 24   LYS A NZ    1 ? 
ATOM   178  N N     . GLU A 1 46  ? -3.851  29.801  12.460 1.00 48.28  ? 25   GLU A N     1 ? 
ATOM   179  C CA    . GLU A 1 46  ? -2.577  30.492  12.280 1.00 47.02  ? 25   GLU A CA    1 ? 
ATOM   180  C C     . GLU A 1 46  ? -2.082  31.149  13.568 1.00 45.61  ? 25   GLU A C     1 ? 
ATOM   181  O O     . GLU A 1 46  ? -0.871  31.245  13.785 1.00 51.71  ? 25   GLU A O     1 ? 
ATOM   182  C CB    . GLU A 1 46  ? -2.673  31.644  11.269 1.00 53.55  ? 25   GLU A CB    1 ? 
ATOM   183  C CG    . GLU A 1 46  ? -2.299  31.288  9.834  1.00 61.99  ? 25   GLU A CG    1 ? 
ATOM   184  C CD    . GLU A 1 46  ? -1.900  32.494  8.978  1.00 70.55  ? 25   GLU A CD    1 ? 
ATOM   185  O OE1   . GLU A 1 46  ? -1.435  32.258  7.839  1.00 77.15  ? 25   GLU A OE1   1 ? 
ATOM   186  O OE2   . GLU A 1 46  ? -2.032  33.662  9.426  1.00 55.00  ? 25   GLU A OE2   1 ? 
ATOM   187  N N     . HIS A 1 47  ? -3.030  31.611  14.397 1.00 47.15  ? 26   HIS A N     1 ? 
ATOM   188  C CA    . HIS A 1 47  ? -2.754  32.432  15.565 1.00 53.41  ? 26   HIS A CA    1 ? 
ATOM   189  C C     . HIS A 1 47  ? -2.379  31.584  16.789 1.00 50.55  ? 26   HIS A C     1 ? 
ATOM   190  O O     . HIS A 1 47  ? -1.964  32.124  17.817 1.00 45.83  ? 26   HIS A O     1 ? 
ATOM   191  C CB    . HIS A 1 47  ? -3.953  33.362  15.832 1.00 61.78  ? 26   HIS A CB    1 ? 
ATOM   192  C CG    . HIS A 1 47  ? -5.290  32.692  16.009 1.00 67.01  ? 26   HIS A CG    1 ? 
ATOM   193  N ND1   . HIS A 1 47  ? -6.023  32.188  14.953 1.00 74.98  ? 26   HIS A ND1   1 ? 
ATOM   194  C CD2   . HIS A 1 47  ? -6.024  32.437  17.111 1.00 72.30  ? 26   HIS A CD2   1 ? 
ATOM   195  C CE1   . HIS A 1 47  ? -7.158  31.661  15.408 1.00 73.23  ? 26   HIS A CE1   1 ? 
ATOM   196  N NE2   . HIS A 1 47  ? -7.172  31.786  16.720 1.00 74.91  ? 26   HIS A NE2   1 ? 
ATOM   197  N N     . ILE A 1 48  ? -2.528  30.256  16.689 1.00 48.66  ? 27   ILE A N     1 ? 
ATOM   198  C CA    . ILE A 1 48  ? -2.308  29.369  17.827 1.00 43.63  ? 27   ILE A CA    1 ? 
ATOM   199  C C     . ILE A 1 48  ? -0.903  28.780  17.706 1.00 35.93  ? 27   ILE A C     1 ? 
ATOM   200  O O     . ILE A 1 48  ? -0.610  28.087  16.740 1.00 33.68  ? 27   ILE A O     1 ? 
ATOM   201  C CB    . ILE A 1 48  ? -3.460  28.350  17.911 1.00 45.13  ? 27   ILE A CB    1 ? 
ATOM   202  C CG1   . ILE A 1 48  ? -4.709  29.071  18.421 1.00 47.61  ? 27   ILE A CG1   1 ? 
ATOM   203  C CG2   . ILE A 1 48  ? -3.117  27.136  18.779 1.00 44.16  ? 27   ILE A CG2   1 ? 
ATOM   204  C CD1   . ILE A 1 48  ? -5.967  28.225  18.462 1.00 51.88  ? 27   ILE A CD1   1 ? 
ATOM   205  N N     . ASN A 1 49  ? -0.015  29.188  18.629 1.00 35.38  ? 28   ASN A N     1 ? 
ATOM   206  C CA    . ASN A 1 49  ? 1.362   28.725  18.636 1.00 34.93  ? 28   ASN A CA    1 ? 
ATOM   207  C C     . ASN A 1 49  ? 1.459   27.465  19.510 1.00 30.76  ? 28   ASN A C     1 ? 
ATOM   208  O O     . ASN A 1 49  ? 1.053   27.486  20.665 1.00 27.70  ? 28   ASN A O     1 ? 
ATOM   209  C CB    . ASN A 1 49  ? 2.318   29.778  19.193 1.00 35.42  ? 28   ASN A CB    1 ? 
ATOM   210  C CG    . ASN A 1 49  ? 2.462   31.023  18.339 1.00 40.61  ? 28   ASN A CG    1 ? 
ATOM   211  O OD1   . ASN A 1 49  ? 2.943   32.052  18.830 1.00 47.54  ? 28   ASN A OD1   1 ? 
ATOM   212  N ND2   . ASN A 1 49  ? 2.059   30.988  17.081 1.00 40.64  ? 28   ASN A ND2   1 ? 
ATOM   213  N N     . VAL A 1 50  ? 2.056   26.403  18.972 1.00 33.42  ? 29   VAL A N     1 ? 
ATOM   214  C CA    . VAL A 1 50  ? 2.184   25.153  19.707 1.00 30.82  ? 29   VAL A CA    1 ? 
ATOM   215  C C     . VAL A 1 50  ? 3.647   24.749  19.777 1.00 26.76  ? 29   VAL A C     1 ? 
ATOM   216  O O     . VAL A 1 50  ? 4.330   24.735  18.750 1.00 27.77  ? 29   VAL A O     1 ? 
ATOM   217  C CB    . VAL A 1 50  ? 1.352   24.059  19.008 1.00 30.40  ? 29   VAL A CB    1 ? 
ATOM   218  C CG1   . VAL A 1 50  ? 1.657   22.646  19.543 1.00 31.55  ? 29   VAL A CG1   1 ? 
ATOM   219  C CG2   . VAL A 1 50  ? -0.126  24.376  19.104 1.00 32.52  ? 29   VAL A CG2   1 ? 
ATOM   220  N N     . LEU A 1 51  ? 4.089   24.381  20.985 1.00 26.34  ? 30   LEU A N     1 ? 
ATOM   221  C CA    . LEU A 1 51  ? 5.367   23.733  21.187 1.00 22.94  ? 30   LEU A CA    1 ? 
ATOM   222  C C     . LEU A 1 51  ? 5.136   22.240  21.442 1.00 24.38  ? 30   LEU A C     1 ? 
ATOM   223  O O     . LEU A 1 51  ? 4.366   21.904  22.344 1.00 24.16  ? 30   LEU A O     1 ? 
ATOM   224  C CB    . LEU A 1 51  ? 6.067   24.390  22.361 1.00 23.48  ? 30   LEU A CB    1 ? 
ATOM   225  C CG    . LEU A 1 51  ? 7.398   23.766  22.791 1.00 23.96  ? 30   LEU A CG    1 ? 
ATOM   226  C CD1   . LEU A 1 51  ? 8.435   23.885  21.665 1.00 26.18  ? 30   LEU A CD1   1 ? 
ATOM   227  C CD2   . LEU A 1 51  ? 7.859   24.432  24.057 1.00 24.17  ? 30   LEU A CD2   1 ? 
ATOM   228  N N     . LEU A 1 52  ? 5.820   21.395  20.658 1.00 24.82  ? 31   LEU A N     1 ? 
ATOM   229  C CA    . LEU A 1 52  ? 5.744   19.940  20.740 1.00 24.25  ? 31   LEU A CA    1 ? 
ATOM   230  C C     . LEU A 1 52  ? 7.113   19.436  21.169 1.00 25.37  ? 31   LEU A C     1 ? 
ATOM   231  O O     . LEU A 1 52  ? 8.078   19.629  20.438 1.00 25.65  ? 31   LEU A O     1 ? 
ATOM   232  C CB    . LEU A 1 52  ? 5.320   19.312  19.410 1.00 23.08  ? 31   LEU A CB    1 ? 
ATOM   233  C CG    . LEU A 1 52  ? 5.290   17.773  19.378 1.00 24.97  ? 31   LEU A CG    1 ? 
ATOM   234  C CD1   . LEU A 1 52  ? 4.271   17.189  20.366 1.00 22.96  ? 31   LEU A CD1   1 ? 
ATOM   235  C CD2   . LEU A 1 52  ? 5.036   17.254  17.988 1.00 25.36  ? 31   LEU A CD2   1 ? 
ATOM   236  N N     . LEU A 1 53  ? 7.183   18.816  22.356 1.00 24.12  ? 32   LEU A N     1 ? 
ATOM   237  C CA    . LEU A 1 53  ? 8.421   18.350  22.942 1.00 22.78  ? 32   LEU A CA    1 ? 
ATOM   238  C C     . LEU A 1 53  ? 8.492   16.826  22.879 1.00 26.13  ? 32   LEU A C     1 ? 
ATOM   239  O O     . LEU A 1 53  ? 7.507   16.164  23.190 1.00 25.28  ? 32   LEU A O     1 ? 
ATOM   240  C CB    . LEU A 1 53  ? 8.510   18.823  24.387 1.00 24.28  ? 32   LEU A CB    1 ? 
ATOM   241  C CG    . LEU A 1 53  ? 8.410   20.335  24.606 1.00 24.12  ? 32   LEU A CG    1 ? 
ATOM   242  C CD1   . LEU A 1 53  ? 8.378   20.684  26.071 1.00 22.53  ? 32   LEU A CD1   1 ? 
ATOM   243  C CD2   . LEU A 1 53  ? 9.587   20.990  23.897 1.00 23.81  ? 32   LEU A CD2   1 ? 
ATOM   244  N N     . GLU A 1 54  ? 9.674   16.293  22.527 1.00 22.55  ? 33   GLU A N     1 ? 
ATOM   245  C CA    . GLU A 1 54  ? 9.901   14.849  22.427 1.00 22.67  ? 33   GLU A CA    1 ? 
ATOM   246  C C     . GLU A 1 54  ? 11.279  14.495  22.997 1.00 23.89  ? 33   GLU A C     1 ? 
ATOM   247  O O     . GLU A 1 54  ? 12.303  15.113  22.637 1.00 22.85  ? 33   GLU A O     1 ? 
ATOM   248  C CB    . GLU A 1 54  ? 9.736   14.369  20.982 1.00 22.34  ? 33   GLU A CB    1 ? 
ATOM   249  C CG    . GLU A 1 54  ? 10.224  12.938  20.725 1.00 22.39  ? 33   GLU A CG    1 ? 
ATOM   250  C CD    . GLU A 1 54  ? 9.528   11.907  21.613 1.00 23.09  ? 33   GLU A CD    1 ? 
ATOM   251  O OE1   . GLU A 1 54  ? 10.211  11.002  22.164 1.00 20.47  ? 33   GLU A OE1   1 ? 
ATOM   252  O OE2   . GLU A 1 54  ? 8.276   12.028  21.753 1.00 19.76  ? 33   GLU A OE2   1 ? 
ATOM   253  N N     . ALA A 1 55  ? 11.308  13.471  23.863 1.00 20.58  ? 34   ALA A N     1 ? 
ATOM   254  C CA    . ALA A 1 55  ? 12.544  13.029  24.503 1.00 20.93  ? 34   ALA A CA    1 ? 
ATOM   255  C C     . ALA A 1 55  ? 13.527  12.401  23.514 1.00 21.94  ? 34   ALA A C     1 ? 
ATOM   256  O O     . ALA A 1 55  ? 14.745  12.549  23.667 1.00 21.09  ? 34   ALA A O     1 ? 
ATOM   257  C CB    . ALA A 1 55  ? 12.216  12.080  25.612 1.00 21.97  ? 34   ALA A CB    1 ? 
ATOM   258  N N     . GLY A 1 56  ? 12.992  11.657  22.543 1.00 23.01  ? 35   GLY A N     1 ? 
ATOM   259  C CA    . GLY A 1 56  ? 13.782  10.988  21.525 1.00 24.02  ? 35   GLY A CA    1 ? 
ATOM   260  C C     . GLY A 1 56  ? 14.117  11.931  20.368 1.00 24.12  ? 35   GLY A C     1 ? 
ATOM   261  O O     . GLY A 1 56  ? 13.835  13.135  20.426 1.00 22.78  ? 35   GLY A O     1 ? 
ATOM   262  N N     . GLY A 1 57  ? 14.784  11.380  19.347 1.00 23.38  ? 36   GLY A N     1 ? 
ATOM   263  C CA    . GLY A 1 57  ? 15.090  12.129  18.135 1.00 24.63  ? 36   GLY A CA    1 ? 
ATOM   264  C C     . GLY A 1 57  ? 14.009  11.929  17.083 1.00 27.30  ? 36   GLY A C     1 ? 
ATOM   265  O O     . GLY A 1 57  ? 12.971  11.317  17.338 1.00 23.54  ? 36   GLY A O     1 ? 
ATOM   266  N N     . GLU A 1 58  ? 14.270  12.477  15.898 1.00 25.53  ? 37   GLU A N     1 ? 
ATOM   267  C CA    . GLU A 1 58  ? 13.430  12.254  14.739 1.00 25.47  ? 37   GLU A CA    1 ? 
ATOM   268  C C     . GLU A 1 58  ? 13.553  10.794  14.323 1.00 22.27  ? 37   GLU A C     1 ? 
ATOM   269  O O     . GLU A 1 58  ? 14.476  10.096  14.722 1.00 22.53  ? 37   GLU A O     1 ? 
ATOM   270  C CB    . GLU A 1 58  ? 13.883  13.215  13.643 1.00 28.95  ? 37   GLU A CB    1 ? 
ATOM   271  C CG    . GLU A 1 58  ? 13.592  14.683  13.938 1.00 29.41  ? 37   GLU A CG    1 ? 
ATOM   272  C CD    . GLU A 1 58  ? 12.128  15.079  13.884 1.00 30.62  ? 37   GLU A CD    1 ? 
ATOM   273  O OE1   . GLU A 1 58  ? 11.882  16.223  14.289 1.00 29.71  ? 37   GLU A OE1   1 ? 
ATOM   274  O OE2   . GLU A 1 58  ? 11.242  14.297  13.466 1.00 30.83  ? 37   GLU A OE2   1 ? 
ATOM   275  N N     . ASN A 1 59  ? 12.564  10.315  13.575 1.00 25.25  ? 38   ASN A N     1 ? 
ATOM   276  C CA    . ASN A 1 59  ? 12.522  8.928   13.142 1.00 22.58  ? 38   ASN A CA    1 ? 
ATOM   277  C C     . ASN A 1 59  ? 13.385  8.771   11.889 1.00 26.04  ? 38   ASN A C     1 ? 
ATOM   278  O O     . ASN A 1 59  ? 12.859  8.726   10.781 1.00 24.85  ? 38   ASN A O     1 ? 
ATOM   279  C CB    . ASN A 1 59  ? 11.082  8.478   12.927 1.00 22.67  ? 38   ASN A CB    1 ? 
ATOM   280  C CG    . ASN A 1 59  ? 10.927  6.999   12.715 1.00 21.42  ? 38   ASN A CG    1 ? 
ATOM   281  O OD1   . ASN A 1 59  ? 11.913  6.256   12.786 1.00 24.83  ? 38   ASN A OD1   1 ? 
ATOM   282  N ND2   . ASN A 1 59  ? 9.699   6.556   12.464 1.00 26.06  ? 38   ASN A ND2   1 ? 
ATOM   283  N N     . THR A 1 60  ? 14.697  8.586   12.101 1.00 27.54  ? 39   THR A N     1 ? 
ATOM   284  C CA    . THR A 1 60  ? 15.679  8.547   11.026 1.00 30.24  ? 39   THR A CA    1 ? 
ATOM   285  C C     . THR A 1 60  ? 16.355  7.184   10.916 1.00 32.45  ? 39   THR A C     1 ? 
ATOM   286  O O     . THR A 1 60  ? 17.074  6.961   9.946  1.00 31.69  ? 39   THR A O     1 ? 
ATOM   287  C CB    . THR A 1 60  ? 16.717  9.658   11.210 1.00 29.76  ? 39   THR A CB    1 ? 
ATOM   288  O OG1   . THR A 1 60  ? 17.369  9.475   12.458 1.00 28.85  ? 39   THR A OG1   1 ? 
ATOM   289  C CG2   . THR A 1 60  ? 16.124  11.052  11.169 1.00 31.19  ? 39   THR A CG2   1 ? 
ATOM   290  N N     . ASN A 1 61  ? 16.085  6.245   11.836 1.00 27.90  ? 40   ASN A N     1 ? 
ATOM   291  C CA    . ASN A 1 61  ? 16.627  4.899   11.724 1.00 31.86  ? 40   ASN A CA    1 ? 
ATOM   292  C C     . ASN A 1 61  ? 15.734  4.051   10.821 1.00 33.52  ? 40   ASN A C     1 ? 
ATOM   293  O O     . ASN A 1 61  ? 14.698  3.549   11.255 1.00 28.00  ? 40   ASN A O     1 ? 
ATOM   294  C CB    . ASN A 1 61  ? 16.745  4.216   13.086 1.00 32.40  ? 40   ASN A CB    1 ? 
ATOM   295  C CG    . ASN A 1 61  ? 17.377  2.845   13.028 1.00 33.95  ? 40   ASN A CG    1 ? 
ATOM   296  O OD1   . ASN A 1 61  ? 17.557  2.275   11.951 1.00 35.36  ? 40   ASN A OD1   1 ? 
ATOM   297  N ND2   . ASN A 1 61  ? 17.718  2.286   14.177 1.00 36.29  ? 40   ASN A ND2   1 ? 
ATOM   298  N N     . GLU A 1 62  ? 16.171  3.845   9.572  1.00 30.81  ? 41   GLU A N     1 ? 
ATOM   299  C CA    . GLU A 1 62  ? 15.317  3.239   8.570  1.00 32.00  ? 41   GLU A CA    1 ? 
ATOM   300  C C     . GLU A 1 62  ? 15.000  1.785   8.911  1.00 26.93  ? 41   GLU A C     1 ? 
ATOM   301  O O     . GLU A 1 62  ? 13.998  1.268   8.438  1.00 25.35  ? 41   GLU A O     1 ? 
ATOM   302  C CB    . GLU A 1 62  ? 15.885  3.320   7.149  1.00 37.45  ? 41   GLU A CB    1 ? 
ATOM   303  C CG    . GLU A 1 62  ? 15.493  4.607   6.426  1.00 44.55  ? 41   GLU A CG    1 ? 
ATOM   304  C CD    . GLU A 1 62  ? 15.636  4.479   4.917  1.00 52.77  ? 41   GLU A CD    1 ? 
ATOM   305  O OE1   . GLU A 1 62  ? 16.520  5.173   4.371  1.00 63.19  ? 41   GLU A OE1   1 ? 
ATOM   306  O OE2   . GLU A 1 62  ? 14.904  3.669   4.300  1.00 53.39  ? 41   GLU A OE2   1 ? 
ATOM   307  N N     . LEU A 1 63  ? 15.834  1.130   9.725  1.00 26.79  ? 42   LEU A N     1 ? 
ATOM   308  C CA    . LEU A 1 63  ? 15.592  -0.254  10.112 1.00 26.54  ? 42   LEU A CA    1 ? 
ATOM   309  C C     . LEU A 1 63  ? 14.243  -0.353  10.829 1.00 27.42  ? 42   LEU A C     1 ? 
ATOM   310  O O     . LEU A 1 63  ? 13.500  -1.329  10.679 1.00 27.32  ? 42   LEU A O     1 ? 
ATOM   311  C CB    . LEU A 1 63  ? 16.770  -0.723  10.977 1.00 28.08  ? 42   LEU A CB    1 ? 
ATOM   312  C CG    . LEU A 1 63  ? 16.639  -2.067  11.696 1.00 28.18  ? 42   LEU A CG    1 ? 
ATOM   313  C CD1   . LEU A 1 63  ? 16.405  -3.205  10.745 1.00 32.70  ? 42   LEU A CD1   1 ? 
ATOM   314  C CD2   . LEU A 1 63  ? 17.910  -2.325  12.496 1.00 30.93  ? 42   LEU A CD2   1 ? 
ATOM   315  N N     . SER A 1 64  ? 13.893  0.698   11.577 1.00 26.87  ? 43   SER A N     1 ? 
ATOM   316  C CA    . SER A 1 64  ? 12.634  0.717   12.312 1.00 26.18  ? 43   SER A CA    1 ? 
ATOM   317  C C     . SER A 1 64  ? 11.408  0.732   11.386 1.00 25.95  ? 43   SER A C     1 ? 
ATOM   318  O O     . SER A 1 64  ? 10.285  0.481   11.839 1.00 25.24  ? 43   SER A O     1 ? 
ATOM   319  C CB    . SER A 1 64  ? 12.608  1.889   13.217 1.00 25.96  ? 43   SER A CB    1 ? 
ATOM   320  O OG    . SER A 1 64  ? 12.343  3.054   12.466 1.00 24.96  ? 43   SER A OG    1 ? 
ATOM   321  N N     . ARG A 1 65  ? 11.605  1.032   10.091 1.00 25.20  ? 44   ARG A N     1 ? 
ATOM   322  C CA    . ARG A 1 65  ? 10.498  1.149   9.156  1.00 24.70  ? 44   ARG A CA    1 ? 
ATOM   323  C C     . ARG A 1 65  ? 10.288  -0.118  8.324  1.00 25.91  ? 44   ARG A C     1 ? 
ATOM   324  O O     . ARG A 1 65  ? 9.397   -0.165  7.474  1.00 25.28  ? 44   ARG A O     1 ? 
ATOM   325  C CB    . ARG A 1 65  ? 10.714  2.368   8.252  1.00 29.21  ? 44   ARG A CB    1 ? 
ATOM   326  C CG    . ARG A 1 65  ? 10.773  3.698   8.982  1.00 26.71  ? 44   ARG A CG    1 ? 
ATOM   327  C CD    . ARG A 1 65  ? 10.869  4.765   7.928  1.00 27.87  ? 44   ARG A CD    1 ? 
ATOM   328  N NE    . ARG A 1 65  ? 10.950  6.100   8.510  1.00 26.11  ? 44   ARG A NE    1 ? 
ATOM   329  C CZ    . ARG A 1 65  ? 9.913   6.813   8.902  1.00 24.67  ? 44   ARG A CZ    1 ? 
ATOM   330  N NH1   . ARG A 1 65  ? 8.682   6.373   8.725  1.00 30.21  ? 44   ARG A NH1   1 ? 
ATOM   331  N NH2   . ARG A 1 65  ? 10.104  7.985   9.418  1.00 25.94  ? 44   ARG A NH2   1 ? 
ATOM   332  N N     . ILE A 1 66  ? 11.106  -1.152  8.546  1.00 29.60  ? 45   ILE A N     1 ? 
ATOM   333  C CA    . ILE A 1 66  ? 11.028  -2.359  7.743  1.00 28.88  ? 45   ILE A CA    1 ? 
ATOM   334  C C     . ILE A 1 66  ? 10.032  -3.330  8.379  1.00 28.16  ? 45   ILE A C     1 ? 
ATOM   335  O O     . ILE A 1 66  ? 10.221  -3.757  9.515  1.00 30.47  ? 45   ILE A O     1 ? 
ATOM   336  C CB    . ILE A 1 66  ? 12.431  -2.981  7.590  1.00 30.96  ? 45   ILE A CB    1 ? 
ATOM   337  C CG1   . ILE A 1 66  ? 13.442  -1.977  7.050  1.00 32.87  ? 45   ILE A CG1   1 ? 
ATOM   338  C CG2   . ILE A 1 66  ? 12.381  -4.235  6.726  1.00 30.81  ? 45   ILE A CG2   1 ? 
ATOM   339  C CD1   . ILE A 1 66  ? 14.839  -2.533  6.907  1.00 34.10  ? 45   ILE A CD1   1 ? 
ATOM   340  N N     . PRO A 1 67  ? 8.952   -3.734  7.683  1.00 29.34  ? 46   PRO A N     1 ? 
ATOM   341  C CA    . PRO A 1 67  ? 7.886   -4.529  8.313  1.00 27.83  ? 46   PRO A CA    1 ? 
ATOM   342  C C     . PRO A 1 67  ? 8.331   -5.857  8.920  1.00 27.35  ? 46   PRO A C     1 ? 
ATOM   343  O O     . PRO A 1 67  ? 7.788   -6.269  9.945  1.00 26.41  ? 46   PRO A O     1 ? 
ATOM   344  C CB    . PRO A 1 67  ? 6.829   -4.749  7.206  1.00 32.69  ? 46   PRO A CB    1 ? 
ATOM   345  C CG    . PRO A 1 67  ? 7.492   -4.277  5.919  1.00 30.64  ? 46   PRO A CG    1 ? 
ATOM   346  C CD    . PRO A 1 67  ? 8.648   -3.374  6.288  1.00 29.39  ? 46   PRO A CD    1 ? 
ATOM   347  N N     . GLY A 1 68  ? 9.324   -6.512  8.294  1.00 25.15  ? 47   GLY A N     1 ? 
ATOM   348  C CA    . GLY A 1 68  ? 9.798   -7.796  8.760  1.00 22.80  ? 47   GLY A CA    1 ? 
ATOM   349  C C     . GLY A 1 68  ? 11.017  -7.737  9.675  1.00 23.75  ? 47   GLY A C     1 ? 
ATOM   350  O O     . GLY A 1 68  ? 11.452  -8.798  10.133 1.00 24.44  ? 47   GLY A O     1 ? 
ATOM   351  N N     . ALA A 1 69  ? 11.620  -6.552  9.866  1.00 23.69  ? 48   ALA A N     1 ? 
ATOM   352  C CA    . ALA A 1 69  ? 12.861  -6.447  10.622 1.00 26.35  ? 48   ALA A CA    1 ? 
ATOM   353  C C     . ALA A 1 69  ? 12.846  -5.343  11.687 1.00 25.74  ? 48   ALA A C     1 ? 
ATOM   354  O O     . ALA A 1 69  ? 13.850  -5.171  12.386 1.00 24.83  ? 48   ALA A O     1 ? 
ATOM   355  C CB    . ALA A 1 69  ? 14.011  -6.215  9.659  1.00 28.55  ? 48   ALA A CB    1 ? 
ATOM   356  N N     . PHE A 1 70  ? 11.749  -4.577  11.789 1.00 24.81  ? 49   PHE A N     1 ? 
ATOM   357  C CA    . PHE A 1 70  ? 11.722  -3.407  12.661 1.00 25.36  ? 49   PHE A CA    1 ? 
ATOM   358  C C     . PHE A 1 70  ? 12.130  -3.756  14.098 1.00 24.92  ? 49   PHE A C     1 ? 
ATOM   359  O O     . PHE A 1 70  ? 12.684  -2.900  14.818 1.00 23.63  ? 49   PHE A O     1 ? 
ATOM   360  C CB    . PHE A 1 70  ? 10.322  -2.766  12.660 1.00 24.08  ? 49   PHE A CB    1 ? 
ATOM   361  C CG    . PHE A 1 70  ? 9.315   -3.628  13.400 1.00 21.79  ? 49   PHE A CG    1 ? 
ATOM   362  C CD1   . PHE A 1 70  ? 8.632   -4.635  12.740 1.00 20.95  ? 49   PHE A CD1   1 ? 
ATOM   363  C CD2   . PHE A 1 70  ? 9.089   -3.453  14.762 1.00 22.36  ? 49   PHE A CD2   1 ? 
ATOM   364  C CE1   . PHE A 1 70  ? 7.806   -5.492  13.427 1.00 21.34  ? 49   PHE A CE1   1 ? 
ATOM   365  C CE2   . PHE A 1 70  ? 8.257   -4.318  15.456 1.00 21.32  ? 49   PHE A CE2   1 ? 
ATOM   366  C CZ    . PHE A 1 70  ? 7.612   -5.334  14.792 1.00 21.37  ? 49   PHE A CZ    1 ? 
ATOM   367  N N     . PHE A 1 71  ? 11.761  -4.967  14.546 1.00 23.49  ? 50   PHE A N     1 ? 
ATOM   368  C CA    . PHE A 1 71  ? 11.898  -5.342  15.953 1.00 24.93  ? 50   PHE A CA    1 ? 
ATOM   369  C C     . PHE A 1 71  ? 13.365  -5.409  16.372 1.00 26.76  ? 50   PHE A C     1 ? 
ATOM   370  O O     . PHE A 1 71  ? 13.674  -5.465  17.568 1.00 23.43  ? 50   PHE A O     1 ? 
ATOM   371  C CB    . PHE A 1 71  ? 11.179  -6.657  16.311 1.00 26.44  ? 50   PHE A CB    1 ? 
ATOM   372  C CG    . PHE A 1 71  ? 11.469  -7.794  15.343 1.00 28.38  ? 50   PHE A CG    1 ? 
ATOM   373  C CD1   . PHE A 1 71  ? 12.583  -8.615  15.508 1.00 33.11  ? 50   PHE A CD1   1 ? 
ATOM   374  C CD2   . PHE A 1 71  ? 10.619  -8.054  14.280 1.00 30.55  ? 50   PHE A CD2   1 ? 
ATOM   375  C CE1   . PHE A 1 71  ? 12.843  -9.653  14.625 1.00 35.64  ? 50   PHE A CE1   1 ? 
ATOM   376  C CE2   . PHE A 1 71  ? 10.896  -9.094  13.391 1.00 34.61  ? 50   PHE A CE2   1 ? 
ATOM   377  C CZ    . PHE A 1 71  ? 12.007  -9.885  13.563 1.00 35.23  ? 50   PHE A CZ    1 ? 
ATOM   378  N N     . LYS A 1 72  ? 14.280  -5.328  15.407 1.00 27.52  ? 51   LYS A N     1 ? 
ATOM   379  C CA    . LYS A 1 72  ? 15.689  -5.232  15.724 1.00 26.77  ? 51   LYS A CA    1 ? 
ATOM   380  C C     . LYS A 1 72  ? 16.023  -3.905  16.404 1.00 27.40  ? 51   LYS A C     1 ? 
ATOM   381  O O     . LYS A 1 72  ? 17.098  -3.805  16.970 1.00 29.68  ? 51   LYS A O     1 ? 
ATOM   382  C CB    . LYS A 1 72  ? 16.573  -5.440  14.482 1.00 33.73  ? 51   LYS A CB    1 ? 
ATOM   383  C CG    . LYS A 1 72  ? 16.755  -6.897  14.147 1.00 37.41  ? 51   LYS A CG    1 ? 
ATOM   384  C CD    . LYS A 1 72  ? 18.031  -7.229  13.380 1.00 51.11  ? 51   LYS A CD    1 ? 
ATOM   385  C CE    . LYS A 1 72  ? 18.515  -8.584  13.823 1.00 56.24  ? 51   LYS A CE    1 ? 
ATOM   386  N NZ    . LYS A 1 72  ? 19.446  -9.237  12.893 1.00 63.44  ? 51   LYS A NZ    1 ? 
ATOM   387  N N     . VAL A 1 73  ? 15.131  -2.905  16.409 1.00 24.05  ? 52   VAL A N     1 ? 
ATOM   388  C CA    . VAL A 1 73  ? 15.448  -1.677  17.121 1.00 24.15  ? 52   VAL A CA    1 ? 
ATOM   389  C C     . VAL A 1 73  ? 14.949  -1.723  18.574 1.00 25.47  ? 52   VAL A C     1 ? 
ATOM   390  O O     . VAL A 1 73  ? 15.230  -0.813  19.349 1.00 26.55  ? 52   VAL A O     1 ? 
ATOM   391  C CB    . VAL A 1 73  ? 14.966  -0.406  16.414 1.00 25.74  ? 52   VAL A CB    1 ? 
ATOM   392  C CG1   . VAL A 1 73  ? 15.388  -0.381  14.951 1.00 26.64  ? 52   VAL A CG1   1 ? 
ATOM   393  C CG2   . VAL A 1 73  ? 13.473  -0.199  16.537 1.00 25.46  ? 52   VAL A CG2   1 ? 
ATOM   394  N N     . LEU A 1 74  ? 14.217  -2.766  18.968 1.00 23.33  ? 53   LEU A N     1 ? 
ATOM   395  C CA    . LEU A 1 74  ? 13.843  -2.903  20.365 1.00 26.96  ? 53   LEU A CA    1 ? 
ATOM   396  C C     . LEU A 1 74  ? 15.127  -3.035  21.185 1.00 28.99  ? 53   LEU A C     1 ? 
ATOM   397  O O     . LEU A 1 74  ? 16.093  -3.662  20.754 1.00 24.92  ? 53   LEU A O     1 ? 
ATOM   398  C CB    . LEU A 1 74  ? 12.918  -4.092  20.604 1.00 25.33  ? 53   LEU A CB    1 ? 
ATOM   399  C CG    . LEU A 1 74  ? 11.579  -4.081  19.862 1.00 28.86  ? 53   LEU A CG    1 ? 
ATOM   400  C CD1   . LEU A 1 74  ? 10.839  -5.386  20.208 1.00 30.79  ? 53   LEU A CD1   1 ? 
ATOM   401  C CD2   . LEU A 1 74  ? 10.730  -2.854  20.141 1.00 30.81  ? 53   LEU A CD2   1 ? 
ATOM   402  N N     . GLY A 1 75  ? 15.156  -2.380  22.338 1.00 25.83  ? 54   GLY A N     1 ? 
ATOM   403  C CA    . GLY A 1 75  ? 16.298  -2.475  23.227 1.00 25.41  ? 54   GLY A CA    1 ? 
ATOM   404  C C     . GLY A 1 75  ? 17.352  -1.419  22.899 1.00 27.59  ? 54   GLY A C     1 ? 
ATOM   405  O O     . GLY A 1 75  ? 18.328  -1.282  23.631 1.00 27.97  ? 54   GLY A O     1 ? 
ATOM   406  N N     . THR A 1 76  ? 17.151  -0.654  21.822 1.00 27.51  ? 55   THR A N     1 ? 
ATOM   407  C CA    . THR A 1 76  ? 18.071  0.398   21.422 1.00 24.98  ? 55   THR A CA    1 ? 
ATOM   408  C C     . THR A 1 76  ? 17.556  1.736   21.952 1.00 25.60  ? 55   THR A C     1 ? 
ATOM   409  O O     . THR A 1 76  ? 16.650  1.780   22.785 1.00 20.02  ? 55   THR A O     1 ? 
ATOM   410  C CB    . THR A 1 76  ? 18.196  0.441   19.901 1.00 25.70  ? 55   THR A CB    1 ? 
ATOM   411  O OG1   . THR A 1 76  ? 16.997  0.995   19.378 1.00 21.90  ? 55   THR A OG1   1 ? 
ATOM   412  C CG2   . THR A 1 76  ? 18.516  -0.908  19.278 1.00 25.97  ? 55   THR A CG2   1 ? 
ATOM   413  N N     . ASP A 1 77  ? 18.143  2.822   21.455 1.00 25.82  ? 56   ASP A N     1 ? 
ATOM   414  C CA    . ASP A 1 77  ? 17.843  4.179   21.871 1.00 26.90  ? 56   ASP A CA    1 ? 
ATOM   415  C C     . ASP A 1 77  ? 16.436  4.589   21.444 1.00 24.53  ? 56   ASP A C     1 ? 
ATOM   416  O O     . ASP A 1 77  ? 15.943  5.628   21.883 1.00 23.83  ? 56   ASP A O     1 ? 
ATOM   417  C CB    . ASP A 1 77  ? 18.897  5.164   21.348 1.00 31.67  ? 56   ASP A CB    1 ? 
ATOM   418  C CG    . ASP A 1 77  ? 18.949  5.400   19.829 1.00 41.58  ? 56   ASP A CG    1 ? 
ATOM   419  O OD1   . ASP A 1 77  ? 18.311  4.648   19.061 1.00 39.33  ? 56   ASP A OD1   1 ? 
ATOM   420  O OD2   . ASP A 1 77  ? 19.658  6.345   19.382 1.00 46.11  ? 56   ASP A OD2   1 ? 
ATOM   421  N N     . TYR A 1 78  ? 15.806  3.792   20.559 1.00 26.00  ? 57   TYR A N     1 ? 
ATOM   422  C CA    . TYR A 1 78  ? 14.427  3.986   20.139 1.00 22.34  ? 57   TYR A CA    1 ? 
ATOM   423  C C     . TYR A 1 78  ? 13.411  3.505   21.188 1.00 23.82  ? 57   TYR A C     1 ? 
ATOM   424  O O     . TYR A 1 78  ? 12.216  3.600   20.939 1.00 22.38  ? 57   TYR A O     1 ? 
ATOM   425  C CB    . TYR A 1 78  ? 14.165  3.194   18.849 1.00 23.34  ? 57   TYR A CB    1 ? 
ATOM   426  C CG    . TYR A 1 78  ? 14.218  4.002   17.560 1.00 22.77  ? 57   TYR A CG    1 ? 
ATOM   427  C CD1   . TYR A 1 78  ? 15.215  4.955   17.330 1.00 22.93  ? 57   TYR A CD1   1 ? 
ATOM   428  C CD2   . TYR A 1 78  ? 13.236  3.847   16.597 1.00 22.89  ? 57   TYR A CD2   1 ? 
ATOM   429  C CE1   . TYR A 1 78  ? 15.253  5.693   16.150 1.00 23.11  ? 57   TYR A CE1   1 ? 
ATOM   430  C CE2   . TYR A 1 78  ? 13.255  4.586   15.424 1.00 22.25  ? 57   TYR A CE2   1 ? 
ATOM   431  C CZ    . TYR A 1 78  ? 14.269  5.502   15.195 1.00 24.13  ? 57   TYR A CZ    1 ? 
ATOM   432  O OH    . TYR A 1 78  ? 14.213  6.212   14.022 1.00 26.71  ? 57   TYR A OH    1 ? 
ATOM   433  N N     . ASP A 1 79  ? 13.871  3.017   22.345 1.00 21.29  ? 58   ASP A N     1 ? 
ATOM   434  C CA    . ASP A 1 79  ? 13.056  2.276   23.295 1.00 20.99  ? 58   ASP A CA    1 ? 
ATOM   435  C C     . ASP A 1 79  ? 13.368  2.774   24.712 1.00 20.64  ? 58   ASP A C     1 ? 
ATOM   436  O O     . ASP A 1 79  ? 14.529  2.925   25.040 1.00 19.24  ? 58   ASP A O     1 ? 
ATOM   437  C CB    . ASP A 1 79  ? 13.386  0.796   23.135 1.00 21.03  ? 58   ASP A CB    1 ? 
ATOM   438  C CG    . ASP A 1 79  ? 12.559  -0.257  23.867 1.00 21.57  ? 58   ASP A CG    1 ? 
ATOM   439  O OD1   . ASP A 1 79  ? 11.708  0.099   24.697 1.00 18.68  ? 58   ASP A OD1   1 ? 
ATOM   440  O OD2   . ASP A 1 79  ? 12.811  -1.453  23.609 1.00 19.86  ? 58   ASP A OD2   1 ? 
ATOM   441  N N     . TRP A 1 80  ? 12.334  2.984   25.554 1.00 19.93  ? 59   TRP A N     1 ? 
ATOM   442  C CA    . TRP A 1 80  ? 12.517  3.288   26.965 1.00 18.54  ? 59   TRP A CA    1 ? 
ATOM   443  C C     . TRP A 1 80  ? 13.041  2.078   27.763 1.00 19.51  ? 59   TRP A C     1 ? 
ATOM   444  O O     . TRP A 1 80  ? 13.534  2.253   28.882 1.00 17.82  ? 59   TRP A O     1 ? 
ATOM   445  C CB    . TRP A 1 80  ? 11.222  3.866   27.556 1.00 18.05  ? 59   TRP A CB    1 ? 
ATOM   446  C CG    . TRP A 1 80  ? 10.867  5.234   27.031 1.00 17.86  ? 59   TRP A CG    1 ? 
ATOM   447  C CD1   . TRP A 1 80  ? 10.203  5.506   25.881 1.00 17.08  ? 59   TRP A CD1   1 ? 
ATOM   448  C CD2   . TRP A 1 80  ? 11.184  6.520   27.614 1.00 19.96  ? 59   TRP A CD2   1 ? 
ATOM   449  N NE1   . TRP A 1 80  ? 10.058  6.859   25.700 1.00 17.15  ? 59   TRP A NE1   1 ? 
ATOM   450  C CE2   . TRP A 1 80  ? 10.659  7.508   26.748 1.00 19.73  ? 59   TRP A CE2   1 ? 
ATOM   451  C CE3   . TRP A 1 80  ? 11.855  6.935   28.778 1.00 23.50  ? 59   TRP A CE3   1 ? 
ATOM   452  C CZ2   . TRP A 1 80  ? 10.811  8.869   26.995 1.00 20.98  ? 59   TRP A CZ2   1 ? 
ATOM   453  C CZ3   . TRP A 1 80  ? 12.021  8.288   29.016 1.00 23.91  ? 59   TRP A CZ3   1 ? 
ATOM   454  C CH2   . TRP A 1 80  ? 11.485  9.237   28.143 1.00 23.00  ? 59   TRP A CH2   1 ? 
ATOM   455  N N     . THR A 1 81  ? 12.902  0.868   27.200 1.00 18.49  ? 60   THR A N     1 ? 
ATOM   456  C CA    . THR A 1 81  ? 13.394  -0.412  27.710 1.00 19.11  ? 60   THR A CA    1 ? 
ATOM   457  C C     . THR A 1 81  ? 12.924  -0.705  29.134 1.00 18.69  ? 60   THR A C     1 ? 
ATOM   458  O O     . THR A 1 81  ? 13.633  -1.368  29.916 1.00 19.04  ? 60   THR A O     1 ? 
ATOM   459  C CB    . THR A 1 81  ? 14.915  -0.548  27.568 1.00 22.32  ? 60   THR A CB    1 ? 
ATOM   460  O OG1   . THR A 1 81  ? 15.564  0.233   28.574 1.00 22.12  ? 60   THR A OG1   1 ? 
ATOM   461  C CG2   . THR A 1 81  ? 15.409  -0.149  26.190 1.00 23.33  ? 60   THR A CG2   1 ? 
ATOM   462  N N     . TYR A 1 82  ? 11.687  -0.303  29.473 1.00 17.69  ? 61   TYR A N     1 ? 
ATOM   463  C CA    . TYR A 1 82  ? 11.133  -0.684  30.768 1.00 17.71  ? 61   TYR A CA    1 ? 
ATOM   464  C C     . TYR A 1 82  ? 10.779  -2.172  30.815 1.00 19.89  ? 61   TYR A C     1 ? 
ATOM   465  O O     . TYR A 1 82  ? 10.474  -2.757  29.783 1.00 19.51  ? 61   TYR A O     1 ? 
ATOM   466  C CB    . TYR A 1 82  ? 9.866   0.098   31.090 1.00 15.71  ? 61   TYR A CB    1 ? 
ATOM   467  C CG    . TYR A 1 82  ? 9.993   1.607   31.136 1.00 15.15  ? 61   TYR A CG    1 ? 
ATOM   468  C CD1   . TYR A 1 82  ? 11.134  2.264   31.600 1.00 16.06  ? 61   TYR A CD1   1 ? 
ATOM   469  C CD2   . TYR A 1 82  ? 8.906   2.390   30.771 1.00 16.23  ? 61   TYR A CD2   1 ? 
ATOM   470  C CE1   . TYR A 1 82  ? 11.184  3.652   31.668 1.00 17.28  ? 61   TYR A CE1   1 ? 
ATOM   471  C CE2   . TYR A 1 82  ? 8.945   3.768   30.856 1.00 14.94  ? 61   TYR A CE2   1 ? 
ATOM   472  C CZ    . TYR A 1 82  ? 10.081  4.400   31.297 1.00 17.07  ? 61   TYR A CZ    1 ? 
ATOM   473  O OH    . TYR A 1 82  ? 9.961   5.760   31.381 1.00 18.96  ? 61   TYR A OH    1 ? 
ATOM   474  N N     . SER A 1 83  ? 10.774  -2.744  32.033 1.00 17.84  ? 62   SER A N     1 ? 
ATOM   475  C CA    . SER A 1 83  ? 10.199  -4.044  32.333 1.00 20.67  ? 62   SER A CA    1 ? 
ATOM   476  C C     . SER A 1 83  ? 9.245   -3.908  33.516 1.00 20.74  ? 62   SER A C     1 ? 
ATOM   477  O O     . SER A 1 83  ? 9.433   -3.041  34.365 1.00 22.69  ? 62   SER A O     1 ? 
ATOM   478  C CB    . SER A 1 83  ? 11.246  -5.089  32.672 1.00 20.66  ? 62   SER A CB    1 ? 
ATOM   479  O OG    . SER A 1 83  ? 12.037  -5.388  31.535 1.00 19.82  ? 62   SER A OG    1 ? 
ATOM   480  N N     . SER A 1 84  ? 8.269   -4.815  33.618 1.00 18.79  ? 63   SER A N     1 ? 
ATOM   481  C CA    . SER A 1 84  ? 7.415   -4.844  34.796 1.00 17.17  ? 63   SER A CA    1 ? 
ATOM   482  C C     . SER A 1 84  ? 8.190   -5.280  36.037 1.00 18.08  ? 63   SER A C     1 ? 
ATOM   483  O O     . SER A 1 84  ? 9.216   -5.960  35.958 1.00 16.94  ? 63   SER A O     1 ? 
ATOM   484  C CB    . SER A 1 84  ? 6.216   -5.763  34.600 1.00 18.91  ? 63   SER A CB    1 ? 
ATOM   485  O OG    . SER A 1 84  ? 6.592   -7.136  34.649 1.00 18.78  ? 63   SER A OG    1 ? 
ATOM   486  N N     . VAL A 1 85  ? 7.597   -4.972  37.192 1.00 18.81  ? 64   VAL A N     1 ? 
ATOM   487  C CA    . VAL A 1 85  ? 7.962   -5.629  38.423 1.00 21.50  ? 64   VAL A CA    1 ? 
ATOM   488  C C     . VAL A 1 85  ? 7.659   -7.117  38.255 1.00 21.44  ? 64   VAL A C     1 ? 
ATOM   489  O O     . VAL A 1 85  ? 6.881   -7.530  37.394 1.00 19.45  ? 64   VAL A O     1 ? 
ATOM   490  C CB    . VAL A 1 85  ? 7.237   -5.032  39.647 1.00 22.75  ? 64   VAL A CB    1 ? 
ATOM   491  C CG1   . VAL A 1 85  ? 7.394   -3.514  39.709 1.00 22.82  ? 64   VAL A CG1   1 ? 
ATOM   492  C CG2   . VAL A 1 85  ? 5.754   -5.406  39.692 1.00 21.04  ? 64   VAL A CG2   1 ? 
ATOM   493  N N     . GLU A 1 86  ? 8.303   -7.943  39.072 1.00 20.99  ? 65   GLU A N     1 ? 
ATOM   494  C CA    . GLU A 1 86  ? 8.008   -9.370  39.041 1.00 24.81  ? 65   GLU A CA    1 ? 
ATOM   495  C C     . GLU A 1 86  ? 6.513   -9.612  39.212 1.00 23.46  ? 65   GLU A C     1 ? 
ATOM   496  O O     . GLU A 1 86  ? 5.886   -9.012  40.073 1.00 22.24  ? 65   GLU A O     1 ? 
ATOM   497  C CB    . GLU A 1 86  ? 8.807   -10.089 40.126 1.00 27.60  ? 65   GLU A CB    1 ? 
ATOM   498  C CG    . GLU A 1 86  ? 10.268  -10.182 39.730 1.00 32.40  ? 65   GLU A CG    1 ? 
ATOM   499  C CD    . GLU A 1 86  ? 11.115  -11.028 40.676 1.00 39.42  ? 65   GLU A CD    1 ? 
ATOM   500  O OE1   . GLU A 1 86  ? 12.282  -11.173 40.300 1.00 43.11  ? 65   GLU A OE1   1 ? 
ATOM   501  O OE2   . GLU A 1 86  ? 10.649  -11.527 41.727 1.00 46.23  ? 65   GLU A OE2   1 ? 
ATOM   502  N N     . GLN A 1 87  ? 5.950   -10.496 38.382 1.00 21.13  ? 66   GLN A N     1 ? 
ATOM   503  C CA    . GLN A 1 87  ? 4.519   -10.718 38.354 1.00 20.95  ? 66   GLN A CA    1 ? 
ATOM   504  C C     . GLN A 1 87  ? 4.190   -12.049 39.016 1.00 21.75  ? 66   GLN A C     1 ? 
ATOM   505  O O     . GLN A 1 87  ? 4.511   -13.100 38.459 1.00 19.86  ? 66   GLN A O     1 ? 
ATOM   506  C CB    . GLN A 1 87  ? 4.079   -10.739 36.887 1.00 19.51  ? 66   GLN A CB    1 ? 
ATOM   507  C CG    . GLN A 1 87  ? 4.195   -9.377  36.223 1.00 21.42  ? 66   GLN A CG    1 ? 
ATOM   508  C CD    . GLN A 1 87  ? 3.274   -8.364  36.866 1.00 20.71  ? 66   GLN A CD    1 ? 
ATOM   509  O OE1   . GLN A 1 87  ? 2.057   -8.541  36.866 1.00 20.40  ? 66   GLN A OE1   1 ? 
ATOM   510  N NE2   . GLN A 1 87  ? 3.825   -7.312  37.453 1.00 21.08  ? 66   GLN A NE2   1 ? 
ATOM   511  N N     . THR A 1 88  ? 3.524   -12.006 40.187 1.00 22.29  ? 67   THR A N     1 ? 
ATOM   512  C CA    . THR A 1 88  ? 3.303   -13.224 40.953 1.00 24.75  ? 67   THR A CA    1 ? 
ATOM   513  C C     . THR A 1 88  ? 2.361   -14.159 40.175 1.00 22.60  ? 67   THR A C     1 ? 
ATOM   514  O O     . THR A 1 88  ? 2.483   -15.372 40.260 1.00 24.51  ? 67   THR A O     1 ? 
ATOM   515  C CB    . THR A 1 88  ? 2.795   -12.886 42.350 1.00 31.00  ? 67   THR A CB    1 ? 
ATOM   516  O OG1   . THR A 1 88  ? 1.634   -12.094 42.146 1.00 33.99  ? 67   THR A OG1   1 ? 
ATOM   517  C CG2   . THR A 1 88  ? 3.769   -12.005 43.120 1.00 35.20  ? 67   THR A CG2   1 ? 
ATOM   518  N N     . GLY A 1 89  ? 1.486   -13.592 39.329 1.00 19.92  ? 68   GLY A N     1 ? 
ATOM   519  C CA    . GLY A 1 89  ? 0.574   -14.372 38.507 1.00 19.56  ? 68   GLY A CA    1 ? 
ATOM   520  C C     . GLY A 1 89  ? 1.242   -15.020 37.288 1.00 19.18  ? 68   GLY A C     1 ? 
ATOM   521  O O     . GLY A 1 89  ? 0.635   -15.886 36.647 1.00 19.08  ? 68   GLY A O     1 ? 
ATOM   522  N N     . LEU A 1 90  ? 2.448   -14.559 36.938 1.00 18.47  ? 69   LEU A N     1 ? 
ATOM   523  C CA    . LEU A 1 90  ? 3.227   -15.097 35.838 1.00 21.51  ? 69   LEU A CA    1 ? 
ATOM   524  C C     . LEU A 1 90  ? 4.513   -15.755 36.353 1.00 23.24  ? 69   LEU A C     1 ? 
ATOM   525  O O     . LEU A 1 90  ? 5.592   -15.586 35.761 1.00 19.35  ? 69   LEU A O     1 ? 
ATOM   526  C CB    . LEU A 1 90  ? 3.530   -13.989 34.839 1.00 20.32  ? 69   LEU A CB    1 ? 
ATOM   527  C CG    . LEU A 1 90  ? 2.344   -13.439 34.047 1.00 22.45  ? 69   LEU A CG    1 ? 
ATOM   528  C CD1   . LEU A 1 90  ? 2.859   -12.309 33.125 1.00 21.13  ? 69   LEU A CD1   1 ? 
ATOM   529  C CD2   . LEU A 1 90  ? 1.581   -14.528 33.253 1.00 21.39  ? 69   LEU A CD2   1 ? 
ATOM   530  N N     . ASN A 1 91  ? 4.407   -16.513 37.456 1.00 23.10  ? 70   ASN A N     1 ? 
ATOM   531  C CA    . ASN A 1 91  ? 5.546   -17.311 37.923 1.00 28.48  ? 70   ASN A CA    1 ? 
ATOM   532  C C     . ASN A 1 91  ? 6.714   -16.373 38.257 1.00 25.43  ? 70   ASN A C     1 ? 
ATOM   533  O O     . ASN A 1 91  ? 7.875   -16.710 38.012 1.00 24.69  ? 70   ASN A O     1 ? 
ATOM   534  C CB    . ASN A 1 91  ? 5.875   -18.380 36.866 1.00 29.83  ? 70   ASN A CB    1 ? 
ATOM   535  C CG    . ASN A 1 91  ? 6.695   -19.556 37.353 1.00 37.78  ? 70   ASN A CG    1 ? 
ATOM   536  O OD1   . ASN A 1 91  ? 6.528   -20.004 38.487 1.00 43.06  ? 70   ASN A OD1   1 ? 
ATOM   537  N ND2   . ASN A 1 91  ? 7.594   -20.071 36.515 1.00 35.32  ? 70   ASN A ND2   1 ? 
ATOM   538  N N     . ASN A 1 92  ? 6.391   -15.165 38.743 1.00 24.83  ? 71   ASN A N     1 ? 
ATOM   539  C CA    . ASN A 1 92  ? 7.379   -14.193 39.201 1.00 29.93  ? 71   ASN A CA    1 ? 
ATOM   540  C C     . ASN A 1 92  ? 8.244   -13.650 38.070 1.00 27.58  ? 71   ASN A C     1 ? 
ATOM   541  O O     . ASN A 1 92  ? 9.272   -13.021 38.355 1.00 27.78  ? 71   ASN A O     1 ? 
ATOM   542  C CB    . ASN A 1 92  ? 8.253   -14.721 40.345 1.00 35.44  ? 71   ASN A CB    1 ? 
ATOM   543  C CG    . ASN A 1 92  ? 7.385   -14.864 41.566 1.00 40.84  ? 71   ASN A CG    1 ? 
ATOM   544  O OD1   . ASN A 1 92  ? 6.678   -13.913 41.928 1.00 43.46  ? 71   ASN A OD1   1 ? 
ATOM   545  N ND2   . ASN A 1 92  ? 7.338   -16.059 42.126 1.00 44.76  ? 71   ASN A ND2   1 ? 
ATOM   546  N N     . ARG A 1 93  ? 7.792   -13.790 36.816 1.00 21.24  ? 72   ARG A N     1 ? 
ATOM   547  C CA    . ARG A 1 93  ? 8.526   -13.207 35.710 1.00 22.24  ? 72   ARG A CA    1 ? 
ATOM   548  C C     . ARG A 1 93  ? 8.393   -11.694 35.690 1.00 19.47  ? 72   ARG A C     1 ? 
ATOM   549  O O     . ARG A 1 93  ? 7.375   -11.126 36.051 1.00 19.34  ? 72   ARG A O     1 ? 
ATOM   550  C CB    . ARG A 1 93  ? 8.045   -13.763 34.362 1.00 22.88  ? 72   ARG A CB    1 ? 
ATOM   551  C CG    . ARG A 1 93  ? 8.491   -15.213 34.211 1.00 25.30  ? 72   ARG A CG    1 ? 
ATOM   552  C CD    . ARG A 1 93  ? 8.286   -15.654 32.764 1.00 30.74  ? 72   ARG A CD    1 ? 
ATOM   553  N NE    . ARG A 1 93  ? 6.861   -15.613 32.505 1.00 27.47  ? 72   ARG A NE    1 ? 
ATOM   554  C CZ    . ARG A 1 93  ? 6.120   -15.183 31.469 1.00 24.89  ? 72   ARG A CZ    1 ? 
ATOM   555  N NH1   . ARG A 1 93  ? 6.583   -14.540 30.416 1.00 23.91  ? 72   ARG A NH1   1 ? 
ATOM   556  N NH2   . ARG A 1 93  ? 4.842   -15.509 31.506 1.00 20.40  ? 72   ARG A NH2   1 ? 
ATOM   557  N N     . SER A 1 94  ? 9.464   -11.034 35.278 1.00 19.56  ? 73   SER A N     1 ? 
ATOM   558  C CA    . SER A 1 94  ? 9.457   -9.624  34.960 1.00 21.99  ? 73   SER A CA    1 ? 
ATOM   559  C C     . SER A 1 94  ? 9.206   -9.477  33.455 1.00 21.87  ? 73   SER A C     1 ? 
ATOM   560  O O     . SER A 1 94  ? 9.866   -10.140 32.686 1.00 22.93  ? 73   SER A O     1 ? 
ATOM   561  C CB    . SER A 1 94  ? 10.767  -9.002  35.410 1.00 25.86  ? 73   SER A CB    1 ? 
ATOM   562  O OG    . SER A 1 94  ? 10.854  -7.694  34.872 1.00 31.82  ? 73   SER A OG    1 ? 
ATOM   563  N N     . ILE A 1 95  ? 8.180   -8.717  33.046 1.00 19.53  ? 74   ILE A N     1 ? 
ATOM   564  C CA    . ILE A 1 95  ? 7.750   -8.708  31.656 1.00 18.92  ? 74   ILE A CA    1 ? 
ATOM   565  C C     . ILE A 1 95  ? 8.340   -7.483  30.958 1.00 18.64  ? 74   ILE A C     1 ? 
ATOM   566  O O     . ILE A 1 95  ? 8.050   -6.336  31.328 1.00 17.22  ? 74   ILE A O     1 ? 
ATOM   567  C CB    . ILE A 1 95  ? 6.219   -8.768  31.559 1.00 18.82  ? 74   ILE A CB    1 ? 
ATOM   568  C CG1   . ILE A 1 95  ? 5.656   -10.047 32.239 1.00 19.46  ? 74   ILE A CG1   1 ? 
ATOM   569  C CG2   . ILE A 1 95  ? 5.736   -8.621  30.116 1.00 18.67  ? 74   ILE A CG2   1 ? 
ATOM   570  C CD1   . ILE A 1 95  ? 6.211   -11.352 31.672 1.00 19.72  ? 74   ILE A CD1   1 ? 
ATOM   571  N N     . TYR A 1 96  ? 9.125   -7.745  29.907 1.00 17.78  ? 75   TYR A N     1 ? 
ATOM   572  C CA    . TYR A 1 96  ? 9.714   -6.699  29.077 1.00 18.08  ? 75   TYR A CA    1 ? 
ATOM   573  C C     . TYR A 1 96  ? 8.577   -5.902  28.446 1.00 17.56  ? 75   TYR A C     1 ? 
ATOM   574  O O     . TYR A 1 96  ? 7.704   -6.448  27.777 1.00 18.25  ? 75   TYR A O     1 ? 
ATOM   575  C CB    . TYR A 1 96  ? 10.653  -7.248  27.997 1.00 20.04  ? 75   TYR A CB    1 ? 
ATOM   576  C CG    . TYR A 1 96  ? 11.452  -6.146  27.289 1.00 19.99  ? 75   TYR A CG    1 ? 
ATOM   577  C CD1   . TYR A 1 96  ? 12.239  -5.265  28.023 1.00 19.96  ? 75   TYR A CD1   1 ? 
ATOM   578  C CD2   . TYR A 1 96  ? 11.359  -5.927  25.908 1.00 22.09  ? 75   TYR A CD2   1 ? 
ATOM   579  C CE1   . TYR A 1 96  ? 12.925  -4.233  27.424 1.00 20.38  ? 75   TYR A CE1   1 ? 
ATOM   580  C CE2   . TYR A 1 96  ? 12.043  -4.888  25.295 1.00 19.45  ? 75   TYR A CE2   1 ? 
ATOM   581  C CZ    . TYR A 1 96  ? 12.806  -4.018  26.067 1.00 20.56  ? 75   TYR A CZ    1 ? 
ATOM   582  O OH    . TYR A 1 96  ? 13.571  -3.003  25.547 1.00 19.69  ? 75   TYR A OH    1 ? 
ATOM   583  N N     . SER A 1 97  ? 8.590   -4.592  28.694 1.00 17.80  ? 76   SER A N     1 ? 
ATOM   584  C CA    . SER A 1 97  ? 7.454   -3.716  28.442 1.00 17.30  ? 76   SER A CA    1 ? 
ATOM   585  C C     . SER A 1 97  ? 7.917   -2.502  27.633 1.00 17.38  ? 76   SER A C     1 ? 
ATOM   586  O O     . SER A 1 97  ? 7.906   -1.372  28.128 1.00 16.99  ? 76   SER A O     1 ? 
ATOM   587  C CB    . SER A 1 97  ? 6.837   -3.292  29.763 1.00 18.15  ? 76   SER A CB    1 ? 
ATOM   588  O OG    . SER A 1 97  ? 6.342   -4.407  30.489 1.00 18.28  ? 76   SER A OG    1 ? 
ATOM   589  N N     . PRO A 1 98  ? 8.373   -2.701  26.375 1.00 19.24  ? 77   PRO A N     1 ? 
ATOM   590  C CA    . PRO A 1 98  ? 8.951   -1.610  25.594 1.00 18.07  ? 77   PRO A CA    1 ? 
ATOM   591  C C     . PRO A 1 98  ? 7.944   -0.523  25.253 1.00 18.20  ? 77   PRO A C     1 ? 
ATOM   592  O O     . PRO A 1 98  ? 6.747   -0.759  25.245 1.00 17.92  ? 77   PRO A O     1 ? 
ATOM   593  C CB    . PRO A 1 98  ? 9.481   -2.337  24.338 1.00 18.59  ? 77   PRO A CB    1 ? 
ATOM   594  C CG    . PRO A 1 98  ? 8.598   -3.584  24.227 1.00 18.06  ? 77   PRO A CG    1 ? 
ATOM   595  C CD    . PRO A 1 98  ? 8.302   -3.969  25.635 1.00 18.81  ? 77   PRO A CD    1 ? 
ATOM   596  N N     . SER A 1 99  ? 8.459   0.663   24.933 1.00 16.28  ? 78   SER A N     1 ? 
ATOM   597  C CA    . SER A 1 99  ? 7.685   1.785   24.458 1.00 16.65  ? 78   SER A CA    1 ? 
ATOM   598  C C     . SER A 1 99  ? 8.625   2.690   23.663 1.00 17.96  ? 78   SER A C     1 ? 
ATOM   599  O O     . SER A 1 99  ? 9.815   2.764   23.973 1.00 17.30  ? 78   SER A O     1 ? 
ATOM   600  C CB    . SER A 1 99  ? 7.028   2.524   25.601 1.00 17.51  ? 78   SER A CB    1 ? 
ATOM   601  O OG    . SER A 1 99  ? 7.995   2.858   26.590 1.00 18.21  ? 78   SER A OG    1 ? 
ATOM   602  N N     . GLY A 1 100 ? 8.082   3.388   22.675 1.00 16.51  ? 79   GLY A N     1 ? 
ATOM   603  C CA    . GLY A 1 100 ? 8.905   4.118   21.721 1.00 18.98  ? 79   GLY A CA    1 ? 
ATOM   604  C C     . GLY A 1 100 ? 9.480   5.412   22.298 1.00 19.44  ? 79   GLY A C     1 ? 
ATOM   605  O O     . GLY A 1 100 ? 8.821   6.115   23.075 1.00 19.96  ? 79   GLY A O     1 ? 
ATOM   606  N N     . LYS A 1 101 ? 10.694  5.731   21.857 1.00 20.87  ? 80   LYS A N     1 ? 
ATOM   607  C CA    . LYS A 1 101 ? 11.373  6.958   22.259 1.00 21.33  ? 80   LYS A CA    1 ? 
ATOM   608  C C     . LYS A 1 101 ? 11.978  7.581   21.007 1.00 21.09  ? 80   LYS A C     1 ? 
ATOM   609  O O     . LYS A 1 101 ? 13.152  7.386   20.683 1.00 20.68  ? 80   LYS A O     1 ? 
ATOM   610  C CB    . LYS A 1 101 ? 12.429  6.745   23.342 1.00 22.42  ? 80   LYS A CB    1 ? 
ATOM   611  C CG    . LYS A 1 101 ? 12.963  8.052   23.957 1.00 24.12  ? 80   LYS A CG    1 ? 
ATOM   612  C CD    . LYS A 1 101 ? 13.861  7.912   25.188 1.00 25.58  ? 80   LYS A CD    1 ? 
ATOM   613  C CE    . LYS A 1 101 ? 14.988  6.997   25.069 1.00 28.16  ? 80   LYS A CE    1 ? 
ATOM   614  N NZ    . LYS A 1 101 ? 15.935  7.046   26.186 1.00 26.04  ? 80   LYS A NZ    1 ? 
ATOM   615  N N     . VAL A 1 102 ? 11.113  8.291   20.290 1.00 21.93  ? 81   VAL A N     1 ? 
ATOM   616  C CA    . VAL A 1 102 ? 11.372  8.777   18.944 1.00 20.10  ? 81   VAL A CA    1 ? 
ATOM   617  C C     . VAL A 1 102 ? 10.099  9.522   18.563 1.00 21.02  ? 81   VAL A C     1 ? 
ATOM   618  O O     . VAL A 1 102 ? 9.043   9.266   19.150 1.00 20.88  ? 81   VAL A O     1 ? 
ATOM   619  C CB    . VAL A 1 102 ? 11.707  7.621   17.989 1.00 20.29  ? 81   VAL A CB    1 ? 
ATOM   620  C CG1   . VAL A 1 102 ? 10.526  6.656   17.817 1.00 20.88  ? 81   VAL A CG1   1 ? 
ATOM   621  C CG2   . VAL A 1 102 ? 12.189  8.067   16.611 1.00 21.72  ? 81   VAL A CG2   1 ? 
ATOM   622  N N     . VAL A 1 103 ? 10.195  10.474  17.632 1.00 21.53  ? 82   VAL A N     1 ? 
ATOM   623  C CA    . VAL A 1 103 ? 9.015   11.031  16.990 1.00 20.96  ? 82   VAL A CA    1 ? 
ATOM   624  C C     . VAL A 1 103 ? 8.260   9.861   16.351 1.00 21.28  ? 82   VAL A C     1 ? 
ATOM   625  O O     . VAL A 1 103 ? 8.765   9.136   15.490 1.00 23.03  ? 82   VAL A O     1 ? 
ATOM   626  C CB    . VAL A 1 103 ? 9.375   12.129  15.968 1.00 21.63  ? 82   VAL A CB    1 ? 
ATOM   627  C CG1   . VAL A 1 103 ? 8.180   12.531  15.121 1.00 21.13  ? 82   VAL A CG1   1 ? 
ATOM   628  C CG2   . VAL A 1 103 ? 9.982   13.338  16.656 1.00 22.30  ? 82   VAL A CG2   1 ? 
ATOM   629  N N     . GLY A 1 104 ? 7.033   9.642   16.821 1.00 19.78  ? 83   GLY A N     1 ? 
ATOM   630  C CA    . GLY A 1 104 ? 6.264   8.456   16.443 1.00 20.23  ? 83   GLY A CA    1 ? 
ATOM   631  C C     . GLY A 1 104 ? 5.975   7.565   17.648 1.00 20.16  ? 83   GLY A C     1 ? 
ATOM   632  O O     . GLY A 1 104 ? 5.051   6.761   17.641 1.00 19.97  ? 83   GLY A O     1 ? 
ATOM   633  N N     . GLY A 1 105 ? 6.778   7.728   18.697 1.00 20.11  ? 84   GLY A N     1 ? 
ATOM   634  C CA    . GLY A 1 105 ? 6.636   6.907   19.881 1.00 20.45  ? 84   GLY A CA    1 ? 
ATOM   635  C C     . GLY A 1 105 ? 6.530   5.430   19.535 1.00 19.40  ? 84   GLY A C     1 ? 
ATOM   636  O O     . GLY A 1 105 ? 7.296   4.888   18.738 1.00 18.98  ? 84   GLY A O     1 ? 
ATOM   637  N N     . SER A 1 106 ? 5.563   4.754   20.156 1.00 18.28  ? 85   SER A N     1 ? 
ATOM   638  C CA    . SER A 1 106 ? 5.486   3.316   20.015 1.00 18.06  ? 85   SER A CA    1 ? 
ATOM   639  C C     . SER A 1 106 ? 5.031   2.941   18.613 1.00 16.34  ? 85   SER A C     1 ? 
ATOM   640  O O     . SER A 1 106 ? 5.274   1.817   18.183 1.00 16.81  ? 85   SER A O     1 ? 
ATOM   641  C CB    . SER A 1 106 ? 4.572   2.718   21.083 1.00 19.34  ? 85   SER A CB    1 ? 
ATOM   642  O OG    . SER A 1 106 ? 5.208   2.821   22.347 1.00 20.59  ? 85   SER A OG    1 ? 
ATOM   643  N N     . SER A 1 107 ? 4.344   3.850   17.920 1.00 16.51  ? 86   SER A N     1 ? 
ATOM   644  C CA    . SER A 1 107 ? 3.955   3.585   16.538 1.00 19.06  ? 86   SER A CA    1 ? 
ATOM   645  C C     . SER A 1 107 ? 5.178   3.475   15.627 1.00 19.95  ? 86   SER A C     1 ? 
ATOM   646  O O     . SER A 1 107 ? 5.045   2.992   14.512 1.00 21.14  ? 86   SER A O     1 ? 
ATOM   647  C CB    . SER A 1 107 ? 2.993   4.630   16.032 1.00 19.56  ? 86   SER A CB    1 ? 
ATOM   648  O OG    . SER A 1 107 ? 3.623   5.854   15.671 1.00 21.25  ? 86   SER A OG    1 ? 
ATOM   649  N N     . ALA A 1 108 ? 6.361   3.910   16.100 1.00 21.00  ? 87   ALA A N     1 ? 
ATOM   650  C CA    . ALA A 1 108 ? 7.594   3.819   15.332 1.00 23.95  ? 87   ALA A CA    1 ? 
ATOM   651  C C     . ALA A 1 108 ? 8.307   2.496   15.566 1.00 24.18  ? 87   ALA A C     1 ? 
ATOM   652  O O     . ALA A 1 108 ? 9.254   2.217   14.843 1.00 22.84  ? 87   ALA A O     1 ? 
ATOM   653  C CB    . ALA A 1 108 ? 8.512   4.969   15.668 1.00 25.77  ? 87   ALA A CB    1 ? 
ATOM   654  N N     . ILE A 1 109 ? 7.864   1.690   16.550 1.00 20.54  ? 88   ILE A N     1 ? 
ATOM   655  C CA    . ILE A 1 109 ? 8.583   0.462   16.879 1.00 22.32  ? 88   ILE A CA    1 ? 
ATOM   656  C C     . ILE A 1 109 ? 7.657   -0.747  17.000 1.00 20.93  ? 88   ILE A C     1 ? 
ATOM   657  O O     . ILE A 1 109 ? 8.082   -1.758  17.554 1.00 21.11  ? 88   ILE A O     1 ? 
ATOM   658  C CB    . ILE A 1 109 ? 9.404   0.614   18.179 1.00 21.24  ? 88   ILE A CB    1 ? 
ATOM   659  C CG1   . ILE A 1 109 ? 8.522   0.794   19.413 1.00 21.18  ? 88   ILE A CG1   1 ? 
ATOM   660  C CG2   . ILE A 1 109 ? 10.425  1.750   18.038 1.00 21.78  ? 88   ILE A CG2   1 ? 
ATOM   661  C CD1   . ILE A 1 109 ? 9.266   0.552   20.727 1.00 24.30  ? 88   ILE A CD1   1 ? 
ATOM   662  N N     . ASN A 1 110 ? 6.446   -0.652  16.471 1.00 21.51  ? 89   ASN A N     1 ? 
ATOM   663  C CA    . ASN A 1 110 ? 5.437   -1.702  16.626 1.00 22.57  ? 89   ASN A CA    1 ? 
ATOM   664  C C     . ASN A 1 110 ? 5.323   -2.497  15.326 1.00 22.30  ? 89   ASN A C     1 ? 
ATOM   665  O O     . ASN A 1 110 ? 5.893   -2.121  14.303 1.00 19.75  ? 89   ASN A O     1 ? 
ATOM   666  C CB    . ASN A 1 110 ? 4.095   -1.172  17.147 1.00 22.10  ? 89   ASN A CB    1 ? 
ATOM   667  C CG    . ASN A 1 110 ? 3.361   -0.209  16.236 1.00 21.52  ? 89   ASN A CG    1 ? 
ATOM   668  O OD1   . ASN A 1 110 ? 3.689   -0.060  15.058 1.00 21.25  ? 89   ASN A OD1   1 ? 
ATOM   669  N ND2   . ASN A 1 110 ? 2.321   0.437   16.754 1.00 21.89  ? 89   ASN A ND2   1 ? 
ATOM   670  N N     . VAL A 1 111 ? 4.566   -3.599  15.371 1.00 20.98  ? 90   VAL A N     1 ? 
ATOM   671  C CA    . VAL A 1 111 ? 4.289   -4.377  14.172 1.00 23.37  ? 90   VAL A CA    1 ? 
ATOM   672  C C     . VAL A 1 111 ? 3.619   -3.469  13.142 1.00 22.51  ? 90   VAL A C     1 ? 
ATOM   673  O O     . VAL A 1 111 ? 4.015   -3.465  11.968 1.00 23.45  ? 90   VAL A O     1 ? 
ATOM   674  C CB    . VAL A 1 111 ? 3.454   -5.638  14.432 1.00 25.35  ? 90   VAL A CB    1 ? 
ATOM   675  C CG1   . VAL A 1 111 ? 3.152   -6.372  13.123 1.00 26.32  ? 90   VAL A CG1   1 ? 
ATOM   676  C CG2   . VAL A 1 111 ? 4.117   -6.587  15.425 1.00 28.67  ? 90   VAL A CG2   1 ? 
ATOM   677  N N     . GLY A 1 112 ? 2.627   -2.711  13.619 1.00 22.14  ? 91   GLY A N     1 ? 
ATOM   678  C CA    . GLY A 1 112 ? 1.969   -1.646  12.879 1.00 23.26  ? 91   GLY A CA    1 ? 
ATOM   679  C C     . GLY A 1 112 ? 0.546   -2.021  12.480 1.00 23.54  ? 91   GLY A C     1 ? 
ATOM   680  O O     . GLY A 1 112 ? -0.017  -1.372  11.608 1.00 24.74  ? 91   GLY A O     1 ? 
ATOM   681  N N     . VAL A 1 113 ? -0.032  -3.057  13.121 1.00 23.26  ? 92   VAL A N     1 ? 
ATOM   682  C CA    . VAL A 1 113 ? -1.356  -3.537  12.776 1.00 23.08  ? 92   VAL A CA    1 ? 
ATOM   683  C C     . VAL A 1 113 ? -2.387  -2.520  13.257 1.00 23.43  ? 92   VAL A C     1 ? 
ATOM   684  O O     . VAL A 1 113 ? -2.249  -1.929  14.324 1.00 20.95  ? 92   VAL A O     1 ? 
ATOM   685  C CB    . VAL A 1 113 ? -1.683  -4.965  13.261 1.00 22.22  ? 92   VAL A CB    1 ? 
ATOM   686  C CG1   . VAL A 1 113 ? -0.676  -5.962  12.722 1.00 23.07  ? 92   VAL A CG1   1 ? 
ATOM   687  C CG2   . VAL A 1 113 ? -1.783  -5.089  14.779 1.00 22.13  ? 92   VAL A CG2   1 ? 
ATOM   688  N N     . TRP A 1 114 ? -3.397  -2.297  12.398 1.00 20.52  ? 93   TRP A N     1 ? 
ATOM   689  C CA    . TRP A 1 114 ? -4.467  -1.363  12.675 1.00 20.89  ? 93   TRP A CA    1 ? 
ATOM   690  C C     . TRP A 1 114 ? -5.740  -2.158  12.920 1.00 20.91  ? 93   TRP A C     1 ? 
ATOM   691  O O     . TRP A 1 114 ? -6.415  -2.592  11.982 1.00 23.10  ? 93   TRP A O     1 ? 
ATOM   692  C CB    . TRP A 1 114 ? -4.625  -0.385  11.515 1.00 20.23  ? 93   TRP A CB    1 ? 
ATOM   693  C CG    . TRP A 1 114 ? -5.563  0.761   11.771 1.00 18.82  ? 93   TRP A CG    1 ? 
ATOM   694  C CD1   . TRP A 1 114 ? -6.898  0.819   11.505 1.00 19.77  ? 93   TRP A CD1   1 ? 
ATOM   695  C CD2   . TRP A 1 114 ? -5.205  2.060   12.281 1.00 19.49  ? 93   TRP A CD2   1 ? 
ATOM   696  N NE1   . TRP A 1 114 ? -7.396  2.039   11.850 1.00 21.84  ? 93   TRP A NE1   1 ? 
ATOM   697  C CE2   . TRP A 1 114 ? -6.387  2.832   12.311 1.00 19.55  ? 93   TRP A CE2   1 ? 
ATOM   698  C CE3   . TRP A 1 114 ? -4.015  2.650   12.691 1.00 19.27  ? 93   TRP A CE3   1 ? 
ATOM   699  C CZ2   . TRP A 1 114 ? -6.413  4.146   12.734 1.00 19.26  ? 93   TRP A CZ2   1 ? 
ATOM   700  C CZ3   . TRP A 1 114 ? -4.043  3.952   13.133 1.00 18.49  ? 93   TRP A CZ3   1 ? 
ATOM   701  C CH2   . TRP A 1 114 ? -5.212  4.699   13.120 1.00 19.49  ? 93   TRP A CH2   1 ? 
ATOM   702  N N     . VAL A 1 115 ? -6.003  -2.410  14.202 1.00 20.73  ? 94   VAL A N     1 ? 
ATOM   703  C CA    . VAL A 1 115 ? -7.059  -3.309  14.641 1.00 20.55  ? 94   VAL A CA    1 ? 
ATOM   704  C C     . VAL A 1 115 ? -7.802  -2.574  15.748 1.00 21.21  ? 94   VAL A C     1 ? 
ATOM   705  O O     . VAL A 1 115 ? -7.486  -2.689  16.934 1.00 21.78  ? 94   VAL A O     1 ? 
ATOM   706  C CB    . VAL A 1 115 ? -6.484  -4.663  15.102 1.00 23.27  ? 94   VAL A CB    1 ? 
ATOM   707  C CG1   . VAL A 1 115 ? -7.560  -5.646  15.528 1.00 25.83  ? 94   VAL A CG1   1 ? 
ATOM   708  C CG2   . VAL A 1 115 ? -5.626  -5.307  14.031 1.00 24.76  ? 94   VAL A CG2   1 ? 
ATOM   709  N N     . ARG A 1 116 ? -8.822  -1.812  15.345 1.00 20.57  ? 95   ARG A N     1 ? 
ATOM   710  C CA    . ARG A 1 116 ? -9.267  -0.682  16.141 1.00 22.27  ? 95   ARG A CA    1 ? 
ATOM   711  C C     . ARG A 1 116 ? -10.244 -1.073  17.246 1.00 22.66  ? 95   ARG A C     1 ? 
ATOM   712  O O     . ARG A 1 116 ? -10.490 -0.282  18.168 1.00 21.62  ? 95   ARG A O     1 ? 
ATOM   713  C CB    . ARG A 1 116 ? -9.896  0.388   15.242 1.00 21.31  ? 95   ARG A CB    1 ? 
ATOM   714  C CG    . ARG A 1 116 ? -11.232 -0.021  14.647 1.00 22.23  ? 95   ARG A CG    1 ? 
ATOM   715  C CD    . ARG A 1 116 ? -11.536 0.904   13.483 1.00 23.62  ? 95   ARG A CD    1 ? 
ATOM   716  N NE    . ARG A 1 116 ? -12.928 0.728   13.084 1.00 25.05  ? 95   ARG A NE    1 ? 
ATOM   717  C CZ    . ARG A 1 116 ? -13.468 1.342   12.044 1.00 23.63  ? 95   ARG A CZ    1 ? 
ATOM   718  N NH1   . ARG A 1 116 ? -12.712 2.129   11.306 1.00 24.45  ? 95   ARG A NH1   1 ? 
ATOM   719  N NH2   . ARG A 1 116 ? -14.752 1.149   11.783 1.00 27.01  ? 95   ARG A NH2   1 ? 
ATOM   720  N N     . GLY A 1 117 ? -10.819 -2.273  17.158 1.00 21.38  ? 96   GLY A N     1 ? 
ATOM   721  C CA    . GLY A 1 117 ? -11.820 -2.701  18.131 1.00 23.00  ? 96   GLY A CA    1 ? 
ATOM   722  C C     . GLY A 1 117 ? -13.229 -2.580  17.550 1.00 25.08  ? 96   GLY A C     1 ? 
ATOM   723  O O     . GLY A 1 117 ? -13.381 -2.499  16.330 1.00 25.82  ? 96   GLY A O     1 ? 
ATOM   724  N N     . THR A 1 118 ? -14.233 -2.532  18.441 1.00 25.02  ? 97   THR A N     1 ? 
ATOM   725  C CA    . THR A 1 118 ? -15.637 -2.748  18.092 1.00 28.29  ? 97   THR A CA    1 ? 
ATOM   726  C C     . THR A 1 118 ? -16.492 -1.617  18.670 1.00 29.18  ? 97   THR A C     1 ? 
ATOM   727  O O     . THR A 1 118 ? -16.059 -0.829  19.531 1.00 23.14  ? 97   THR A O     1 ? 
ATOM   728  C CB    . THR A 1 118 ? -16.153 -4.088  18.638 1.00 29.72  ? 97   THR A CB    1 ? 
ATOM   729  O OG1   . THR A 1 118 ? -16.188 -3.954  20.059 1.00 27.35  ? 97   THR A OG1   1 ? 
ATOM   730  C CG2   . THR A 1 118 ? -15.256 -5.275  18.326 1.00 29.97  ? 97   THR A CG2   1 ? 
ATOM   731  N N     . LYS A 1 119 ? -17.754 -1.624  18.234 1.00 27.82  ? 98   LYS A N     1 ? 
ATOM   732  C CA    . LYS A 1 119 ? -18.764 -0.703  18.720 1.00 29.20  ? 98   LYS A CA    1 ? 
ATOM   733  C C     . LYS A 1 119 ? -18.846 -0.689  20.243 1.00 28.39  ? 98   LYS A C     1 ? 
ATOM   734  O O     . LYS A 1 119 ? -18.906 0.371   20.846 1.00 28.68  ? 98   LYS A O     1 ? 
ATOM   735  C CB    . LYS A 1 119 ? -20.120 -1.051  18.095 1.00 30.93  ? 98   LYS A CB    1 ? 
ATOM   736  C CG    . LYS A 1 119 ? -21.305 -0.303  18.729 1.00 36.58  ? 98   LYS A CG    1 ? 
ATOM   737  C CD    . LYS A 1 119 ? -22.607 -0.458  17.936 1.00 42.33  ? 98   LYS A CD    1 ? 
ATOM   738  C CE    . LYS A 1 119 ? -23.806 0.074   18.685 1.00 47.86  ? 98   LYS A CE    1 ? 
ATOM   739  N NZ    . LYS A 1 119 ? -23.713 1.514   18.990 1.00 46.33  ? 98   LYS A NZ    1 ? 
ATOM   740  N N     . GLU A 1 120 ? -18.910 -1.863  20.868 1.00 30.39  ? 99   GLU A N     1 ? 
ATOM   741  C CA    . GLU A 1 120 ? -19.032 -1.930  22.317 1.00 31.51  ? 99   GLU A CA    1 ? 
ATOM   742  C C     . GLU A 1 120 ? -17.824 -1.276  22.992 1.00 27.03  ? 99   GLU A C     1 ? 
ATOM   743  O O     . GLU A 1 120 ? -17.993 -0.665  24.027 1.00 25.59  ? 99   GLU A O     1 ? 
ATOM   744  C CB    . GLU A 1 120 ? -19.307 -3.278  22.994 1.00 35.44  ? 99   GLU A CB    1 ? 
ATOM   745  C CG    . GLU A 1 120 ? -18.962 -4.557  22.239 1.00 46.81  ? 99   GLU A CG    1 ? 
ATOM   746  C CD    . GLU A 1 120 ? -19.921 -4.970  21.143 1.00 52.68  ? 99   GLU A CD    1 ? 
ATOM   747  O OE1   . GLU A 1 120 ? -19.776 -4.421  20.021 1.00 52.61  ? 99   GLU A OE1   1 ? 
ATOM   748  O OE2   . GLU A 1 120 ? -20.798 -5.823  21.408 1.00 62.79  ? 99   GLU A OE2   1 ? 
ATOM   749  N N     . ASP A 1 121 ? -16.623 -1.430  22.417 1.00 25.63  ? 100  ASP A N     1 ? 
ATOM   750  C CA    . ASP A 1 121 ? -15.437 -0.781  22.965 1.00 25.86  ? 100  ASP A CA    1 ? 
ATOM   751  C C     . ASP A 1 121 ? -15.644 0.736   23.071 1.00 24.01  ? 100  ASP A C     1 ? 
ATOM   752  O O     . ASP A 1 121 ? -15.521 1.308   24.148 1.00 22.26  ? 100  ASP A O     1 ? 
ATOM   753  C CB    . ASP A 1 121 ? -14.192 -1.068  22.140 1.00 22.89  ? 100  ASP A CB    1 ? 
ATOM   754  C CG    . ASP A 1 121 ? -13.736 -2.512  22.103 1.00 24.77  ? 100  ASP A CG    1 ? 
ATOM   755  O OD1   . ASP A 1 121 ? -13.943 -3.219  23.121 1.00 22.48  ? 100  ASP A OD1   1 ? 
ATOM   756  O OD2   . ASP A 1 121 ? -13.087 -2.888  21.101 1.00 23.88  ? 100  ASP A OD2   1 ? 
ATOM   757  N N     . TYR A 1 122 ? -16.006 1.371   21.950 1.00 22.51  ? 101  TYR A N     1 ? 
ATOM   758  C CA    . TYR A 1 122 ? -16.091 2.818   21.899 1.00 22.82  ? 101  TYR A CA    1 ? 
ATOM   759  C C     . TYR A 1 122 ? -17.261 3.314   22.740 1.00 23.89  ? 101  TYR A C     1 ? 
ATOM   760  O O     . TYR A 1 122 ? -17.110 4.279   23.477 1.00 25.21  ? 101  TYR A O     1 ? 
ATOM   761  C CB    . TYR A 1 122 ? -16.033 3.289   20.446 1.00 22.30  ? 101  TYR A CB    1 ? 
ATOM   762  C CG    . TYR A 1 122 ? -14.639 3.080   19.880 1.00 23.63  ? 101  TYR A CG    1 ? 
ATOM   763  C CD1   . TYR A 1 122 ? -13.588 3.976   20.130 1.00 22.10  ? 101  TYR A CD1   1 ? 
ATOM   764  C CD2   . TYR A 1 122 ? -14.363 1.952   19.130 1.00 22.51  ? 101  TYR A CD2   1 ? 
ATOM   765  C CE1   . TYR A 1 122 ? -12.330 3.752   19.585 1.00 21.07  ? 101  TYR A CE1   1 ? 
ATOM   766  C CE2   . TYR A 1 122 ? -13.113 1.725   18.585 1.00 23.73  ? 101  TYR A CE2   1 ? 
ATOM   767  C CZ    . TYR A 1 122 ? -12.078 2.609   18.856 1.00 21.16  ? 101  TYR A CZ    1 ? 
ATOM   768  O OH    . TYR A 1 122 ? -10.860 2.325   18.299 1.00 20.82  ? 101  TYR A OH    1 ? 
ATOM   769  N N     . ASP A 1 123 ? -18.383 2.596   22.695 1.00 26.91  ? 102  ASP A N     1 ? 
ATOM   770  C CA    . ASP A 1 123 ? -19.551 2.940   23.483 1.00 25.37  ? 102  ASP A CA    1 ? 
ATOM   771  C C     . ASP A 1 123 ? -19.258 2.829   24.969 1.00 24.94  ? 102  ASP A C     1 ? 
ATOM   772  O O     . ASP A 1 123 ? -19.816 3.594   25.746 1.00 25.20  ? 102  ASP A O     1 ? 
ATOM   773  C CB    . ASP A 1 123 ? -20.759 2.088   23.098 1.00 27.15  ? 102  ASP A CB    1 ? 
ATOM   774  C CG    . ASP A 1 123 ? -21.415 2.478   21.787 1.00 26.76  ? 102  ASP A CG    1 ? 
ATOM   775  O OD1   . ASP A 1 123 ? -21.124 3.611   21.275 1.00 27.38  ? 102  ASP A OD1   1 ? 
ATOM   776  O OD2   . ASP A 1 123 ? -22.173 1.631   21.275 1.00 30.80  ? 102  ASP A OD2   1 ? 
ATOM   777  N N     . SER A 1 124 ? -18.433 1.866   25.380 1.00 24.95  ? 103  SER A N     1 ? 
ATOM   778  C CA    . SER A 1 124 ? -18.187 1.658   26.800 1.00 24.70  ? 103  SER A CA    1 ? 
ATOM   779  C C     . SER A 1 124 ? -17.567 2.885   27.471 1.00 22.24  ? 103  SER A C     1 ? 
ATOM   780  O O     . SER A 1 124 ? -17.699 3.046   28.687 1.00 25.27  ? 103  SER A O     1 ? 
ATOM   781  C CB    . SER A 1 124 ? -17.301 0.442   27.060 1.00 25.98  ? 103  SER A CB    1 ? 
ATOM   782  O OG    . SER A 1 124 ? -15.964 0.664   26.613 1.00 26.17  ? 103  SER A OG    1 ? 
ATOM   783  N N     . TRP A 1 125 ? -16.833 3.728   26.729 1.00 22.59  ? 104  TRP A N     1 ? 
ATOM   784  C CA    . TRP A 1 125 ? -16.164 4.858   27.372 1.00 22.88  ? 104  TRP A CA    1 ? 
ATOM   785  C C     . TRP A 1 125 ? -17.235 5.812   27.912 1.00 22.74  ? 104  TRP A C     1 ? 
ATOM   786  O O     . TRP A 1 125 ? -17.145 6.309   29.041 1.00 23.49  ? 104  TRP A O     1 ? 
ATOM   787  C CB    . TRP A 1 125 ? -15.227 5.585   26.398 1.00 22.79  ? 104  TRP A CB    1 ? 
ATOM   788  C CG    . TRP A 1 125 ? -14.089 4.773   25.830 1.00 23.04  ? 104  TRP A CG    1 ? 
ATOM   789  C CD1   . TRP A 1 125 ? -13.911 3.412   25.836 1.00 24.76  ? 104  TRP A CD1   1 ? 
ATOM   790  C CD2   . TRP A 1 125 ? -12.978 5.311   25.076 1.00 25.42  ? 104  TRP A CD2   1 ? 
ATOM   791  N NE1   . TRP A 1 125 ? -12.761 3.061   25.175 1.00 24.28  ? 104  TRP A NE1   1 ? 
ATOM   792  C CE2   . TRP A 1 125 ? -12.174 4.210   24.675 1.00 24.59  ? 104  TRP A CE2   1 ? 
ATOM   793  C CE3   . TRP A 1 125 ? -12.582 6.604   24.721 1.00 22.17  ? 104  TRP A CE3   1 ? 
ATOM   794  C CZ2   . TRP A 1 125 ? -11.009 4.383   23.924 1.00 21.11  ? 104  TRP A CZ2   1 ? 
ATOM   795  C CZ3   . TRP A 1 125 ? -11.453 6.768   23.952 1.00 21.34  ? 104  TRP A CZ3   1 ? 
ATOM   796  C CH2   . TRP A 1 125 ? -10.659 5.672   23.584 1.00 22.19  ? 104  TRP A CH2   1 ? 
ATOM   797  N N     . GLU A 1 126 ? -18.289 6.017   27.101 1.00 24.11  ? 105  GLU A N     1 ? 
ATOM   798  C CA    . GLU A 1 126 ? -19.402 6.866   27.492 1.00 25.71  ? 105  GLU A CA    1 ? 
ATOM   799  C C     . GLU A 1 126 ? -20.152 6.222   28.653 1.00 26.68  ? 105  GLU A C     1 ? 
ATOM   800  O O     . GLU A 1 126 ? -20.511 6.893   29.621 1.00 23.14  ? 105  GLU A O     1 ? 
ATOM   801  C CB    . GLU A 1 126 ? -20.329 7.177   26.317 1.00 25.82  ? 105  GLU A CB    1 ? 
ATOM   802  C CG    . GLU A 1 126 ? -21.523 8.051   26.697 1.00 29.82  ? 105  GLU A CG    1 ? 
ATOM   803  C CD    . GLU A 1 126 ? -22.240 8.575   25.470 1.00 31.50  ? 105  GLU A CD    1 ? 
ATOM   804  O OE1   . GLU A 1 126 ? -22.059 9.745   25.107 1.00 34.05  ? 105  GLU A OE1   1 ? 
ATOM   805  O OE2   . GLU A 1 126 ? -22.911 7.772   24.812 1.00 36.87  ? 105  GLU A OE2   1 ? 
ATOM   806  N N     . ALA A 1 127 ? -20.370 4.916   28.565 1.00 26.80  ? 106  ALA A N     1 ? 
ATOM   807  C CA    . ALA A 1 127 ? -21.121 4.205   29.581 1.00 27.43  ? 106  ALA A CA    1 ? 
ATOM   808  C C     . ALA A 1 127 ? -20.439 4.332   30.939 1.00 30.72  ? 106  ALA A C     1 ? 
ATOM   809  O O     . ALA A 1 127 ? -21.133 4.354   31.962 1.00 26.87  ? 106  ALA A O     1 ? 
ATOM   810  C CB    . ALA A 1 127 ? -21.281 2.761   29.184 1.00 32.67  ? 106  ALA A CB    1 ? 
ATOM   811  N N     . GLN A 1 128 ? -19.100 4.446   30.957 1.00 26.92  ? 107  GLN A N     1 ? 
ATOM   812  C CA    . GLN A 1 128 ? -18.415 4.526   32.237 1.00 27.00  ? 107  GLN A CA    1 ? 
ATOM   813  C C     . GLN A 1 128 ? -18.117 5.981   32.613 1.00 26.98  ? 107  GLN A C     1 ? 
ATOM   814  O O     . GLN A 1 128 ? -17.342 6.207   33.539 1.00 29.09  ? 107  GLN A O     1 ? 
ATOM   815  C CB    . GLN A 1 128 ? -17.185 3.618   32.348 1.00 27.99  ? 107  GLN A CB    1 ? 
ATOM   816  C CG    . GLN A 1 128 ? -16.037 3.992   31.410 1.00 25.59  ? 107  GLN A CG    1 ? 
ATOM   817  C CD    . GLN A 1 128 ? -15.140 5.133   31.853 1.00 26.24  ? 107  GLN A CD    1 ? 
ATOM   818  O OE1   . GLN A 1 128 ? -14.966 6.150   31.157 1.00 30.70  ? 107  GLN A OE1   1 ? 
ATOM   819  N NE2   . GLN A 1 128 ? -14.471 4.942   32.973 1.00 23.21  ? 107  GLN A NE2   1 ? 
ATOM   820  N N     . GLY A 1 129 ? -18.729 6.961   31.938 1.00 27.34  ? 108  GLY A N     1 ? 
ATOM   821  C CA    . GLY A 1 129 ? -18.797 8.328   32.462 1.00 27.10  ? 108  GLY A CA    1 ? 
ATOM   822  C C     . GLY A 1 129 ? -18.169 9.386   31.547 1.00 28.78  ? 108  GLY A C     1 ? 
ATOM   823  O O     . GLY A 1 129 ? -18.034 10.546  31.933 1.00 30.73  ? 108  GLY A O     1 ? 
ATOM   824  N N     . ALA A 1 130 ? -17.775 9.005   30.327 1.00 27.67  ? 109  ALA A N     1 ? 
ATOM   825  C CA    . ALA A 1 130 ? -17.127 9.929   29.407 1.00 27.82  ? 109  ALA A CA    1 ? 
ATOM   826  C C     . ALA A 1 130 ? -18.121 10.352  28.333 1.00 27.47  ? 109  ALA A C     1 ? 
ATOM   827  O O     . ALA A 1 130 ? -18.159 9.794   27.228 1.00 25.62  ? 109  ALA A O     1 ? 
ATOM   828  C CB    . ALA A 1 130 ? -15.911 9.284   28.773 1.00 28.94  ? 109  ALA A CB    1 ? 
ATOM   829  N N     . LYS A 1 131 ? -18.947 11.346  28.669 1.00 28.28  ? 110  LYS A N     1 ? 
ATOM   830  C CA    . LYS A 1 131 ? -20.054 11.701  27.802 1.00 28.28  ? 110  LYS A CA    1 ? 
ATOM   831  C C     . LYS A 1 131 ? -19.518 12.212  26.469 1.00 26.06  ? 110  LYS A C     1 ? 
ATOM   832  O O     . LYS A 1 131 ? -18.645 13.061  26.442 1.00 23.45  ? 110  LYS A O     1 ? 
ATOM   833  C CB    . LYS A 1 131 ? -20.899 12.741  28.546 1.00 35.34  ? 110  LYS A CB    1 ? 
ATOM   834  C CG    . LYS A 1 131 ? -22.199 13.069  27.863 1.00 44.24  ? 110  LYS A CG    1 ? 
ATOM   835  C CD    . LYS A 1 131 ? -23.185 11.912  27.683 1.00 48.95  ? 110  LYS A CD    1 ? 
ATOM   836  C CE    . LYS A 1 131 ? -24.374 12.410  26.893 1.00 60.69  ? 110  LYS A CE    1 ? 
ATOM   837  N NZ    . LYS A 1 131 ? -24.969 11.413  25.999 1.00 61.64  ? 110  LYS A NZ    1 ? 
ATOM   838  N N     . GLY A 1 132 ? -20.037 11.690  25.355 1.00 27.00  ? 111  GLY A N     1 ? 
ATOM   839  C CA    . GLY A 1 132 ? -19.647 12.192  24.052 1.00 28.89  ? 111  GLY A CA    1 ? 
ATOM   840  C C     . GLY A 1 132 ? -18.611 11.306  23.356 1.00 25.03  ? 111  GLY A C     1 ? 
ATOM   841  O O     . GLY A 1 132 ? -18.302 11.540  22.200 1.00 30.32  ? 111  GLY A O     1 ? 
ATOM   842  N N     . TRP A 1 133 ? -18.049 10.337  24.079 1.00 23.62  ? 112  TRP A N     1 ? 
ATOM   843  C CA    . TRP A 1 133 ? -17.056 9.410   23.561 1.00 22.83  ? 112  TRP A CA    1 ? 
ATOM   844  C C     . TRP A 1 133 ? -17.718 8.063   23.306 1.00 23.20  ? 112  TRP A C     1 ? 
ATOM   845  O O     . TRP A 1 133 ? -17.854 7.258   24.230 1.00 23.89  ? 112  TRP A O     1 ? 
ATOM   846  C CB    . TRP A 1 133 ? -15.913 9.243   24.572 1.00 22.14  ? 112  TRP A CB    1 ? 
ATOM   847  C CG    . TRP A 1 133 ? -15.078 10.481  24.778 1.00 22.69  ? 112  TRP A CG    1 ? 
ATOM   848  C CD1   . TRP A 1 133 ? -15.388 11.583  25.519 1.00 24.16  ? 112  TRP A CD1   1 ? 
ATOM   849  C CD2   . TRP A 1 133 ? -13.761 10.713  24.254 1.00 22.58  ? 112  TRP A CD2   1 ? 
ATOM   850  N NE1   . TRP A 1 133 ? -14.368 12.490  25.468 1.00 22.56  ? 112  TRP A NE1   1 ? 
ATOM   851  C CE2   . TRP A 1 133 ? -13.352 11.979  24.717 1.00 22.94  ? 112  TRP A CE2   1 ? 
ATOM   852  C CE3   . TRP A 1 133 ? -12.881 9.957   23.471 1.00 22.70  ? 112  TRP A CE3   1 ? 
ATOM   853  C CZ2   . TRP A 1 133 ? -12.104 12.511  24.407 1.00 24.47  ? 112  TRP A CZ2   1 ? 
ATOM   854  C CZ3   . TRP A 1 133 ? -11.647 10.480  23.174 1.00 22.68  ? 112  TRP A CZ3   1 ? 
ATOM   855  C CH2   . TRP A 1 133 ? -11.267 11.737  23.632 1.00 22.66  ? 112  TRP A CH2   1 ? 
ATOM   856  N N     . ASN A 1 134 ? -18.065 7.800   22.043 1.00 24.24  ? 113  ASN A N     1 ? 
ATOM   857  C CA    . ASN A 1 134 ? -18.891 6.659   21.685 1.00 23.51  ? 113  ASN A CA    1 ? 
ATOM   858  C C     . ASN A 1 134 ? -18.537 6.223   20.272 1.00 21.83  ? 113  ASN A C     1 ? 
ATOM   859  O O     . ASN A 1 134 ? -17.681 6.829   19.625 1.00 20.78  ? 113  ASN A O     1 ? 
ATOM   860  C CB    . ASN A 1 134 ? -20.370 6.970   21.885 1.00 29.22  ? 113  ASN A CB    1 ? 
ATOM   861  C CG    . ASN A 1 134 ? -20.780 8.204   21.125 1.00 33.27  ? 113  ASN A CG    1 ? 
ATOM   862  O OD1   . ASN A 1 134 ? -20.516 8.309   19.925 1.00 34.31  ? 113  ASN A OD1   1 ? 
ATOM   863  N ND2   . ASN A 1 134 ? -21.380 9.164   21.813 1.00 36.95  ? 113  ASN A ND2   1 ? 
ATOM   864  N N     . PHE A 1 135 ? -19.156 5.135   19.821 1.00 21.81  ? 114  PHE A N     1 ? 
ATOM   865  C CA    . PHE A 1 135 ? -18.815 4.560   18.534 1.00 27.46  ? 114  PHE A CA    1 ? 
ATOM   866  C C     . PHE A 1 135 ? -19.161 5.514   17.391 1.00 27.61  ? 114  PHE A C     1 ? 
ATOM   867  O O     . PHE A 1 135 ? -18.506 5.532   16.371 1.00 26.80  ? 114  PHE A O     1 ? 
ATOM   868  C CB    . PHE A 1 135 ? -19.550 3.238   18.309 1.00 28.32  ? 114  PHE A CB    1 ? 
ATOM   869  C CG    . PHE A 1 135 ? -19.020 2.465   17.119 1.00 28.28  ? 114  PHE A CG    1 ? 
ATOM   870  C CD1   . PHE A 1 135 ? -17.666 2.195   16.995 1.00 30.62  ? 114  PHE A CD1   1 ? 
ATOM   871  C CD2   . PHE A 1 135 ? -19.876 2.033   16.114 1.00 30.63  ? 114  PHE A CD2   1 ? 
ATOM   872  C CE1   . PHE A 1 135 ? -17.178 1.477   15.923 1.00 35.05  ? 114  PHE A CE1   1 ? 
ATOM   873  C CE2   . PHE A 1 135 ? -19.384 1.316   15.035 1.00 32.41  ? 114  PHE A CE2   1 ? 
ATOM   874  C CZ    . PHE A 1 135 ? -18.042 1.035   14.941 1.00 34.96  ? 114  PHE A CZ    1 ? 
ATOM   875  N N     . SER A 1 136 ? -20.234 6.276   17.549 1.00 30.66  ? 115  SER A N     1 ? 
ATOM   876  C CA    . SER A 1 136 ? -20.678 7.180   16.509 1.00 30.37  ? 115  SER A CA    1 ? 
ATOM   877  C C     . SER A 1 136 ? -19.620 8.246   16.255 1.00 29.57  ? 115  SER A C     1 ? 
ATOM   878  O O     . SER A 1 136 ? -19.267 8.539   15.108 1.00 27.69  ? 115  SER A O     1 ? 
ATOM   879  C CB    . SER A 1 136 ? -22.033 7.773   16.881 1.00 37.34  ? 115  SER A CB    1 ? 
ATOM   880  O OG    . SER A 1 136 ? -22.490 8.624   15.843 1.00 42.63  ? 115  SER A OG    1 ? 
ATOM   881  N N     . LYS A 1 137 ? -19.084 8.818   17.335 1.00 29.11  ? 116  LYS A N     1 ? 
ATOM   882  C CA    . LYS A 1 137 ? -17.984 9.753   17.219 1.00 28.05  ? 116  LYS A CA    1 ? 
ATOM   883  C C     . LYS A 1 137 ? -16.740 9.050   16.661 1.00 26.86  ? 116  LYS A C     1 ? 
ATOM   884  O O     . LYS A 1 137 ? -16.022 9.596   15.819 1.00 27.20  ? 116  LYS A O     1 ? 
ATOM   885  C CB    . LYS A 1 137 ? -17.862 10.359  18.618 1.00 31.56  ? 116  LYS A CB    1 ? 
ATOM   886  C CG    . LYS A 1 137 ? -17.500 11.794  18.678 1.00 36.73  ? 116  LYS A CG    1 ? 
ATOM   887  C CD    . LYS A 1 137 ? -18.207 12.730  17.718 1.00 32.24  ? 116  LYS A CD    1 ? 
ATOM   888  C CE    . LYS A 1 137 ? -17.510 14.025  17.910 1.00 33.65  ? 116  LYS A CE    1 ? 
ATOM   889  N NZ    . LYS A 1 137 ? -17.791 14.967  16.824 1.00 35.12  ? 116  LYS A NZ    1 ? 
ATOM   890  N N     . ALA A 1 138 ? -16.467 7.821   17.109 1.00 23.04  ? 117  ALA A N     1 ? 
ATOM   891  C CA    . ALA A 1 138 ? -15.307 7.103   16.599 1.00 25.54  ? 117  ALA A CA    1 ? 
ATOM   892  C C     . ALA A 1 138 ? -15.368 6.962   15.074 1.00 26.74  ? 117  ALA A C     1 ? 
ATOM   893  O O     . ALA A 1 138 ? -14.371 7.178   14.384 1.00 23.57  ? 117  ALA A O     1 ? 
ATOM   894  C CB    . ALA A 1 138 ? -15.190 5.753   17.295 1.00 27.22  ? 117  ALA A CB    1 ? 
ATOM   895  N N     . LEU A 1 139 ? -16.523 6.534   14.546 1.00 29.00  ? 118  LEU A N     1 ? 
ATOM   896  C CA    . LEU A 1 139 ? -16.707 6.381   13.107 1.00 27.31  ? 118  LEU A CA    1 ? 
ATOM   897  C C     . LEU A 1 139 ? -16.434 7.691   12.377 1.00 26.87  ? 118  LEU A C     1 ? 
ATOM   898  O O     . LEU A 1 139 ? -15.769 7.682   11.343 1.00 26.56  ? 118  LEU A O     1 ? 
ATOM   899  C CB    . LEU A 1 139 ? -18.128 5.872   12.852 1.00 30.38  ? 118  LEU A CB    1 ? 
ATOM   900  C CG    . LEU A 1 139 ? -18.280 4.418   12.390 1.00 34.61  ? 118  LEU A CG    1 ? 
ATOM   901  C CD1   . LEU A 1 139 ? -17.201 3.461   12.757 1.00 32.77  ? 118  LEU A CD1   1 ? 
ATOM   902  C CD2   . LEU A 1 139 ? -19.633 3.921   12.891 1.00 40.33  ? 118  LEU A CD2   1 ? 
ATOM   903  N N     . GLU A 1 140 ? -16.950 8.804   12.912 1.00 28.67  ? 119  GLU A N     1 ? 
ATOM   904  C CA    . GLU A 1 140 ? -16.685 10.134  12.374 1.00 33.39  ? 119  GLU A CA    1 ? 
ATOM   905  C C     . GLU A 1 140 ? -15.182 10.428  12.328 1.00 33.32  ? 119  GLU A C     1 ? 
ATOM   906  O O     . GLU A 1 140 ? -14.645 10.861  11.298 1.00 30.55  ? 119  GLU A O     1 ? 
ATOM   907  C CB    . GLU A 1 140 ? -17.416 11.198  13.198 1.00 37.72  ? 119  GLU A CB    1 ? 
ATOM   908  C CG    . GLU A 1 140 ? -17.308 12.593  12.583 1.00 39.19  ? 119  GLU A CG    1 ? 
ATOM   909  C CD    . GLU A 1 140 ? -17.549 13.750  13.530 1.00 40.25  ? 119  GLU A CD    1 ? 
ATOM   910  O OE1   . GLU A 1 140 ? -17.133 14.893  13.247 1.00 48.06  ? 119  GLU A OE1   1 ? 
ATOM   911  O OE2   . GLU A 1 140 ? -18.134 13.510  14.580 1.00 33.83  ? 119  GLU A OE2   1 ? 
ATOM   912  N N     . MET A 1 141 ? -14.468 10.141  13.423 1.00 27.41  ? 120  MET A N     1 ? 
ATOM   913  C CA    . MET A 1 141 ? -13.033 10.364  13.439 1.00 26.74  ? 120  MET A CA    1 ? 
ATOM   914  C C     . MET A 1 141 ? -12.285 9.412   12.494 1.00 23.77  ? 120  MET A C     1 ? 
ATOM   915  O O     . MET A 1 141 ? -11.319 9.813   11.868 1.00 25.03  ? 120  MET A O     1 ? 
ATOM   916  C CB    . MET A 1 141 ? -12.499 10.271  14.872 1.00 26.26  ? 120  MET A CB    1 ? 
ATOM   917  C CG    . MET A 1 141 ? -13.129 11.289  15.794 1.00 29.38  ? 120  MET A CG    1 ? 
ATOM   918  S SD    . MET A 1 141 ? -12.790 12.953  15.185 1.00 31.10  ? 120  MET A SD    1 ? 
ATOM   919  C CE    . MET A 1 141 ? -13.938 13.763  16.298 1.00 39.71  ? 120  MET A CE    1 ? 
ATOM   920  N N     . PHE A 1 142 ? -12.717 8.156   12.358 1.00 24.42  ? 121  PHE A N     1 ? 
ATOM   921  C CA    . PHE A 1 142 ? -11.994 7.215   11.504 1.00 26.10  ? 121  PHE A CA    1 ? 
ATOM   922  C C     . PHE A 1 142 ? -12.129 7.601   10.021 1.00 24.35  ? 121  PHE A C     1 ? 
ATOM   923  O O     . PHE A 1 142 ? -11.340 7.149   9.204  1.00 24.85  ? 121  PHE A O     1 ? 
ATOM   924  C CB    . PHE A 1 142 ? -12.426 5.769   11.808 1.00 25.22  ? 121  PHE A CB    1 ? 
ATOM   925  C CG    . PHE A 1 142 ? -11.873 5.235   13.122 1.00 26.65  ? 121  PHE A CG    1 ? 
ATOM   926  C CD1   . PHE A 1 142 ? -10.545 5.440   13.480 1.00 28.03  ? 121  PHE A CD1   1 ? 
ATOM   927  C CD2   . PHE A 1 142 ? -12.703 4.575   14.031 1.00 27.20  ? 121  PHE A CD2   1 ? 
ATOM   928  C CE1   . PHE A 1 142 ? -10.054 4.956   14.685 1.00 28.93  ? 121  PHE A CE1   1 ? 
ATOM   929  C CE2   . PHE A 1 142 ? -12.215 4.128   15.255 1.00 28.93  ? 121  PHE A CE2   1 ? 
ATOM   930  C CZ    . PHE A 1 142 ? -10.898 4.332   15.582 1.00 28.14  ? 121  PHE A CZ    1 ? 
ATOM   931  N N     . GLN A 1 143 ? -13.107 8.452   9.670  1.00 25.97  ? 122  GLN A N     1 ? 
ATOM   932  C CA    . GLN A 1 143 ? -13.201 8.967   8.312  1.00 27.25  ? 122  GLN A CA    1 ? 
ATOM   933  C C     . GLN A 1 143 ? -12.031 9.907   8.060  1.00 26.34  ? 122  GLN A C     1 ? 
ATOM   934  O O     . GLN A 1 143 ? -11.423 9.866   6.998  1.00 32.11  ? 122  GLN A O     1 ? 
ATOM   935  C CB    . GLN A 1 143 ? -14.509 9.717   8.042  1.00 27.37  ? 122  GLN A CB    1 ? 
ATOM   936  C CG    . GLN A 1 143 ? -15.751 8.834   8.093  1.00 28.69  ? 122  GLN A CG    1 ? 
ATOM   937  C CD    . GLN A 1 143 ? -15.827 7.838   6.957  1.00 30.21  ? 122  GLN A CD    1 ? 
ATOM   938  O OE1   . GLN A 1 143 ? -16.008 6.622   7.140  1.00 30.35  ? 122  GLN A OE1   1 ? 
ATOM   939  N NE2   . GLN A 1 143 ? -15.635 8.359   5.764  1.00 26.78  ? 122  GLN A NE2   1 ? 
ATOM   940  N N     . LYS A 1 144 ? -11.685 10.705  9.069  1.00 27.34  ? 123  LYS A N     1 ? 
ATOM   941  C CA    . LYS A 1 144 ? -10.560 11.632  8.995  1.00 29.21  ? 123  LYS A CA    1 ? 
ATOM   942  C C     . LYS A 1 144 ? -9.206  10.933  9.153  1.00 28.67  ? 123  LYS A C     1 ? 
ATOM   943  O O     . LYS A 1 144 ? -8.218  11.436  8.648  1.00 27.44  ? 123  LYS A O     1 ? 
ATOM   944  C CB    . LYS A 1 144 ? -10.517 12.634  10.152 1.00 31.56  ? 123  LYS A CB    1 ? 
ATOM   945  C CG    . LYS A 1 144 ? -11.679 13.555  10.316 1.00 37.90  ? 123  LYS A CG    1 ? 
ATOM   946  C CD    . LYS A 1 144 ? -11.454 14.380  11.574 1.00 40.05  ? 123  LYS A CD    1 ? 
ATOM   947  C CE    . LYS A 1 144 ? -12.497 15.409  11.787 1.00 43.77  ? 123  LYS A CE    1 ? 
ATOM   948  N NZ    . LYS A 1 144 ? -12.096 16.166  12.976 1.00 46.57  ? 123  LYS A NZ    1 ? 
ATOM   949  N N     . ILE A 1 145 ? -9.164  9.807   9.879  1.00 26.47  ? 124  ILE A N     1 ? 
ATOM   950  C CA    . ILE A 1 145 ? -7.918  9.120   10.216 1.00 24.55  ? 124  ILE A CA    1 ? 
ATOM   951  C C     . ILE A 1 145 ? -7.526  8.133   9.128  1.00 22.68  ? 124  ILE A C     1 ? 
ATOM   952  O O     . ILE A 1 145 ? -6.381  8.140   8.708  1.00 25.06  ? 124  ILE A O     1 ? 
ATOM   953  C CB    . ILE A 1 145 ? -8.021  8.384   11.571 1.00 24.79  ? 124  ILE A CB    1 ? 
ATOM   954  C CG1   . ILE A 1 145 ? -8.203  9.368   12.710 1.00 23.68  ? 124  ILE A CG1   1 ? 
ATOM   955  C CG2   . ILE A 1 145 ? -6.794  7.495   11.791 1.00 23.64  ? 124  ILE A CG2   1 ? 
ATOM   956  C CD1   . ILE A 1 145 ? -8.756  8.801   14.003 1.00 25.45  ? 124  ILE A CD1   1 ? 
ATOM   957  N N     . GLU A 1 146 ? -8.449  7.258   8.721  1.00 22.54  ? 125  GLU A N     1 ? 
ATOM   958  C CA    . GLU A 1 146 ? -8.092  6.135   7.872  1.00 22.59  ? 125  GLU A CA    1 ? 
ATOM   959  C C     . GLU A 1 146 ? -8.029  6.490   6.386  1.00 25.03  ? 125  GLU A C     1 ? 
ATOM   960  O O     . GLU A 1 146 ? -8.852  7.239   5.856  1.00 26.83  ? 125  GLU A O     1 ? 
ATOM   961  C CB    . GLU A 1 146 ? -9.087  4.999   8.050  1.00 25.37  ? 125  GLU A CB    1 ? 
ATOM   962  C CG    . GLU A 1 146 ? -9.089  4.448   9.464  1.00 26.51  ? 125  GLU A CG    1 ? 
ATOM   963  C CD    . GLU A 1 146 ? -9.996  3.272   9.655  1.00 27.08  ? 125  GLU A CD    1 ? 
ATOM   964  O OE1   . GLU A 1 146 ? -10.846 3.036   8.768  1.00 28.41  ? 125  GLU A OE1   1 ? 
ATOM   965  O OE2   . GLU A 1 146 ? -9.854  2.601   10.719 1.00 27.17  ? 125  GLU A OE2   1 ? 
ATOM   966  N N     . GLN A 1 147 ? -7.033  5.898   5.724  1.00 27.25  ? 126  GLN A N     1 ? 
ATOM   967  C CA    . GLN A 1 147 ? -6.929  5.900   4.273  1.00 27.24  ? 126  GLN A CA    1 ? 
ATOM   968  C C     . GLN A 1 147 ? -6.728  4.464   3.815  1.00 26.56  ? 126  GLN A C     1 ? 
ATOM   969  O O     . GLN A 1 147 ? -5.604  4.014   3.679  1.00 24.77  ? 126  GLN A O     1 ? 
ATOM   970  C CB    . GLN A 1 147 ? -5.813  6.825   3.816  1.00 28.99  ? 126  GLN A CB    1 ? 
ATOM   971  C CG    . GLN A 1 147 ? -5.534  6.746   2.319  1.00 34.13  ? 126  GLN A CG    1 ? 
ATOM   972  C CD    . GLN A 1 147 ? -4.544  7.776   1.845  1.00 34.10  ? 126  GLN A CD    1 ? 
ATOM   973  O OE1   . GLN A 1 147 ? -4.342  8.832   2.453  1.00 44.22  ? 126  GLN A OE1   1 ? 
ATOM   974  N NE2   . GLN A 1 147 ? -3.928  7.474   0.728  1.00 37.77  ? 126  GLN A NE2   1 ? 
ATOM   975  N N     . THR A 1 148 ? -7.837  3.737   3.619  1.00 31.12  ? 127  THR A N     1 ? 
ATOM   976  C CA    . THR A 1 148 ? -7.788  2.327   3.286  1.00 28.16  ? 127  THR A CA    1 ? 
ATOM   977  C C     . THR A 1 148 ? -8.675  2.045   2.076  1.00 32.41  ? 127  THR A C     1 ? 
ATOM   978  O O     . THR A 1 148 ? -9.664  2.740   1.855  1.00 29.58  ? 127  THR A O     1 ? 
ATOM   979  C CB    . THR A 1 148 ? -8.199  1.484   4.494  1.00 26.95  ? 127  THR A CB    1 ? 
ATOM   980  O OG1   . THR A 1 148 ? -8.224  0.126   4.067  1.00 25.06  ? 127  THR A OG1   1 ? 
ATOM   981  C CG2   . THR A 1 148 ? -9.521  1.917   5.103  1.00 26.55  ? 127  THR A CG2   1 ? 
ATOM   982  N N     . ASN A 1 149 ? -8.300  0.996   1.325  1.00 30.84  ? 128  ASN A N     1 ? 
ATOM   983  C CA    . ASN A 1 149 ? -9.105  0.479   0.226  1.00 36.16  ? 128  ASN A CA    1 ? 
ATOM   984  C C     . ASN A 1 149 ? -10.326 -0.269  0.751  1.00 39.32  ? 128  ASN A C     1 ? 
ATOM   985  O O     . ASN A 1 149 ? -11.164 -0.683  -0.050 1.00 36.81  ? 128  ASN A O     1 ? 
ATOM   986  C CB    . ASN A 1 149 ? -8.268  -0.361  -0.748 1.00 37.85  ? 128  ASN A CB    1 ? 
ATOM   987  C CG    . ASN A 1 149 ? -7.723  -1.644  -0.160 1.00 41.38  ? 128  ASN A CG    1 ? 
ATOM   988  O OD1   . ASN A 1 149 ? -8.103  -2.053  0.951  1.00 49.94  ? 128  ASN A OD1   1 ? 
ATOM   989  N ND2   . ASN A 1 149 ? -6.841  -2.307  -0.892 1.00 45.78  ? 128  ASN A ND2   1 ? 
ATOM   990  N N     . LEU A 1 150 ? -10.449 -0.424  2.082  1.00 36.57  ? 129  LEU A N     1 ? 
ATOM   991  C CA    . LEU A 1 150 ? -11.694 -0.916  2.665  1.00 35.46  ? 129  LEU A CA    1 ? 
ATOM   992  C C     . LEU A 1 150 ? -12.771 0.162   2.605  1.00 31.91  ? 129  LEU A C     1 ? 
ATOM   993  O O     . LEU A 1 150 ? -13.941 -0.134  2.813  1.00 34.52  ? 129  LEU A O     1 ? 
ATOM   994  C CB    . LEU A 1 150 ? -11.534 -1.393  4.108  1.00 35.12  ? 129  LEU A CB    1 ? 
ATOM   995  C CG    . LEU A 1 150 ? -10.758 -2.701  4.290  1.00 35.64  ? 129  LEU A CG    1 ? 
ATOM   996  C CD1   . LEU A 1 150 ? -10.531 -2.933  5.778  1.00 36.61  ? 129  LEU A CD1   1 ? 
ATOM   997  C CD2   . LEU A 1 150 ? -11.502 -3.879  3.664  1.00 39.36  ? 129  LEU A CD2   1 ? 
ATOM   998  N N     . GLY A 1 151 ? -12.358 1.408   2.372  1.00 30.77  ? 130  GLY A N     1 ? 
ATOM   999  C CA    . GLY A 1 151 ? -13.280 2.526   2.241  1.00 30.78  ? 130  GLY A CA    1 ? 
ATOM   1000 C C     . GLY A 1 151 ? -13.381 2.950   0.768  1.00 34.22  ? 130  GLY A C     1 ? 
ATOM   1001 O O     . GLY A 1 151 ? -12.659 2.421   -0.067 1.00 34.14  ? 130  GLY A O     1 ? 
ATOM   1002 N N     . PRO A 1 152 ? -14.243 3.930   0.400  1.00 35.12  ? 131  PRO A N     1 ? 
ATOM   1003 C CA    . PRO A 1 152 ? -15.119 4.618   1.355  1.00 33.04  ? 131  PRO A CA    1 ? 
ATOM   1004 C C     . PRO A 1 152 ? -16.308 3.754   1.774  1.00 33.30  ? 131  PRO A C     1 ? 
ATOM   1005 O O     . PRO A 1 152 ? -16.833 2.950   0.981  1.00 29.58  ? 131  PRO A O     1 ? 
ATOM   1006 C CB    . PRO A 1 152 ? -15.577 5.886   0.585  1.00 35.25  ? 131  PRO A CB    1 ? 
ATOM   1007 C CG    . PRO A 1 152 ? -15.553 5.442   -0.866 1.00 38.04  ? 131  PRO A CG    1 ? 
ATOM   1008 C CD    . PRO A 1 152 ? -14.388 4.447   -0.974 1.00 39.55  ? 131  PRO A CD    1 ? 
ATOM   1009 N N     . SER A 1 153 ? -16.703 3.922   3.043  1.00 28.75  ? 132  SER A N     1 ? 
ATOM   1010 C CA    . SER A 1 153 ? -17.876 3.287   3.603  1.00 30.13  ? 132  SER A CA    1 ? 
ATOM   1011 C C     . SER A 1 153 ? -18.206 3.970   4.930  1.00 29.86  ? 132  SER A C     1 ? 
ATOM   1012 O O     . SER A 1 153 ? -17.453 4.827   5.392  1.00 30.57  ? 132  SER A O     1 ? 
ATOM   1013 C CB    . SER A 1 153 ? -17.661 1.787   3.793  1.00 35.13  ? 132  SER A CB    1 ? 
ATOM   1014 O OG    . SER A 1 153 ? -16.820 1.526   4.916  1.00 32.10  ? 132  SER A OG    1 ? 
ATOM   1015 N N     . LYS A 1 154 ? -19.309 3.567   5.551  1.00 30.30  ? 133  LYS A N     1 ? 
ATOM   1016 C CA    . LYS A 1 154 ? -19.639 4.071   6.866  1.00 33.08  ? 133  LYS A CA    1 ? 
ATOM   1017 C C     . LYS A 1 154 ? -18.585 3.630   7.887  1.00 34.10  ? 133  LYS A C     1 ? 
ATOM   1018 O O     . LYS A 1 154 ? -18.411 4.322   8.872  1.00 30.42  ? 133  LYS A O     1 ? 
ATOM   1019 C CB    . LYS A 1 154 ? -21.041 3.671   7.314  1.00 36.43  ? 133  LYS A CB    1 ? 
ATOM   1020 C CG    . LYS A 1 154 ? -21.298 2.209   7.665  1.00 47.89  ? 133  LYS A CG    1 ? 
ATOM   1021 C CD    . LYS A 1 154 ? -22.510 1.960   8.568  1.00 55.89  ? 133  LYS A CD    1 ? 
ATOM   1022 C CE    . LYS A 1 154 ? -22.449 2.749   9.866  1.00 56.46  ? 133  LYS A CE    1 ? 
ATOM   1023 N NZ    . LYS A 1 154 ? -23.218 2.170   10.977 1.00 60.10  ? 133  LYS A NZ    1 ? 
ATOM   1024 N N     . TYR A 1 155 ? -17.862 2.528   7.624  1.00 32.68  ? 134  TYR A N     1 ? 
ATOM   1025 C CA    . TYR A 1 155 ? -16.904 1.972   8.583  1.00 33.80  ? 134  TYR A CA    1 ? 
ATOM   1026 C C     . TYR A 1 155 ? -15.469 2.483   8.392  1.00 31.90  ? 134  TYR A C     1 ? 
ATOM   1027 O O     . TYR A 1 155 ? -14.680 2.443   9.332  1.00 28.26  ? 134  TYR A O     1 ? 
ATOM   1028 C CB    . TYR A 1 155 ? -17.002 0.443   8.471  1.00 33.73  ? 134  TYR A CB    1 ? 
ATOM   1029 C CG    . TYR A 1 155 ? -18.293 -0.094  9.072  1.00 36.13  ? 134  TYR A CG    1 ? 
ATOM   1030 C CD1   . TYR A 1 155 ? -18.523 -0.011  10.443 1.00 41.25  ? 134  TYR A CD1   1 ? 
ATOM   1031 C CD2   . TYR A 1 155 ? -19.281 -0.668  8.284  1.00 40.07  ? 134  TYR A CD2   1 ? 
ATOM   1032 C CE1   . TYR A 1 155 ? -19.704 -0.471  11.011 1.00 46.18  ? 134  TYR A CE1   1 ? 
ATOM   1033 C CE2   . TYR A 1 155 ? -20.473 -1.118  8.836  1.00 38.90  ? 134  TYR A CE2   1 ? 
ATOM   1034 C CZ    . TYR A 1 155 ? -20.680 -1.030  10.200 1.00 45.15  ? 134  TYR A CZ    1 ? 
ATOM   1035 O OH    . TYR A 1 155 ? -21.842 -1.497  10.745 1.00 54.06  ? 134  TYR A OH    1 ? 
ATOM   1036 N N     . HIS A 1 156 ? -15.108 2.926   7.181  1.00 27.29  ? 135  HIS A N     1 ? 
ATOM   1037 C CA    . HIS A 1 156 ? -13.716 3.193   6.837  1.00 27.74  ? 135  HIS A CA    1 ? 
ATOM   1038 C C     . HIS A 1 156 ? -13.582 4.418   5.932  1.00 30.27  ? 135  HIS A C     1 ? 
ATOM   1039 O O     . HIS A 1 156 ? -14.299 4.554   4.925  1.00 26.54  ? 135  HIS A O     1 ? 
ATOM   1040 C CB    . HIS A 1 156 ? -13.067 2.005   6.116  1.00 27.15  ? 135  HIS A CB    1 ? 
ATOM   1041 C CG    . HIS A 1 156 ? -13.036 0.761   6.945  1.00 29.45  ? 135  HIS A CG    1 ? 
ATOM   1042 N ND1   . HIS A 1 156 ? -12.322 0.672   8.123  1.00 29.20  ? 135  HIS A ND1   1 ? 
ATOM   1043 C CD2   . HIS A 1 156 ? -13.672 -0.418  6.798  1.00 26.68  ? 135  HIS A CD2   1 ? 
ATOM   1044 C CE1   . HIS A 1 156 ? -12.509 -0.541  8.645  1.00 31.26  ? 135  HIS A CE1   1 ? 
ATOM   1045 N NE2   . HIS A 1 156 ? -13.329 -1.215  7.866  1.00 27.70  ? 135  HIS A NE2   1 ? 
ATOM   1046 N N     . GLY A 1 157 ? -12.605 5.272   6.272  1.00 31.12  ? 136  GLY A N     1 ? 
ATOM   1047 C CA    . GLY A 1 157 ? -12.153 6.334   5.394  1.00 28.80  ? 136  GLY A CA    1 ? 
ATOM   1048 C C     . GLY A 1 157 ? -11.259 5.837   4.260  1.00 30.98  ? 136  GLY A C     1 ? 
ATOM   1049 O O     . GLY A 1 157 ? -10.439 4.919   4.410  1.00 28.27  ? 136  GLY A O     1 ? 
ATOM   1050 N N     . ASP A 1 158 ? -11.372 6.532   3.123  1.00 30.90  ? 137  ASP A N     1 ? 
ATOM   1051 C CA    . ASP A 1 158 ? -10.530 6.287   1.964  1.00 31.62  ? 137  ASP A CA    1 ? 
ATOM   1052 C C     . ASP A 1 158 ? -9.536  7.427   1.784  1.00 27.88  ? 137  ASP A C     1 ? 
ATOM   1053 O O     . ASP A 1 158 ? -8.572  7.280   1.054  1.00 28.01  ? 137  ASP A O     1 ? 
ATOM   1054 C CB    . ASP A 1 158 ? -11.362 6.065   0.707  1.00 31.61  ? 137  ASP A CB    1 ? 
ATOM   1055 C CG    . ASP A 1 158 ? -12.314 7.202   0.353  1.00 32.63  ? 137  ASP A CG    1 ? 
ATOM   1056 O OD1   . ASP A 1 158 ? -12.717 7.957   1.257  1.00 29.90  ? 137  ASP A OD1   1 ? 
ATOM   1057 O OD2   . ASP A 1 158 ? -12.621 7.359   -0.839 1.00 32.52  ? 137  ASP A OD2   1 ? 
ATOM   1058 N N     . LYS A 1 159 ? -9.741  8.558   2.459  1.00 32.18  ? 138  LYS A N     1 ? 
ATOM   1059 C CA    . LYS A 1 159 ? -8.971  9.756   2.175  1.00 30.40  ? 138  LYS A CA    1 ? 
ATOM   1060 C C     . LYS A 1 159 ? -8.426  10.393  3.443  1.00 31.51  ? 138  LYS A C     1 ? 
ATOM   1061 O O     . LYS A 1 159 ? -8.111  11.578  3.444  1.00 31.63  ? 138  LYS A O     1 ? 
ATOM   1062 C CB    . LYS A 1 159 ? -9.863  10.792  1.477  1.00 38.63  ? 138  LYS A CB    1 ? 
ATOM   1063 C CG    . LYS A 1 159 ? -10.281 10.364  0.052  1.00 45.06  ? 138  LYS A CG    1 ? 
ATOM   1064 C CD    . LYS A 1 159 ? -11.256 11.303  -0.655 1.00 49.44  ? 138  LYS A CD    1 ? 
ATOM   1065 C CE    . LYS A 1 159 ? -11.094 11.328  -2.146 1.00 52.44  ? 138  LYS A CE    1 ? 
ATOM   1066 N NZ    . LYS A 1 159 ? -10.823 10.024  -2.763 1.00 52.55  ? 138  LYS A NZ    1 ? 
ATOM   1067 N N     . GLY A 1 160 ? -8.319  9.622   4.534  1.00 29.70  ? 139  GLY A N     1 ? 
ATOM   1068 C CA    . GLY A 1 160 ? -7.825  10.172  5.784  1.00 30.14  ? 139  GLY A CA    1 ? 
ATOM   1069 C C     . GLY A 1 160 ? -6.305  10.264  5.784  1.00 27.22  ? 139  GLY A C     1 ? 
ATOM   1070 O O     . GLY A 1 160 ? -5.660  10.010  4.773  1.00 26.38  ? 139  GLY A O     1 ? 
ATOM   1071 N N     . LYS A 1 161 ? -5.744  10.593  6.953  1.00 26.96  ? 140  LYS A N     1 ? 
ATOM   1072 C CA    . LYS A 1 161 ? -4.335  10.920  7.080  1.00 27.64  ? 140  LYS A CA    1 ? 
ATOM   1073 C C     . LYS A 1 161 ? -3.456  9.678   7.111  1.00 28.54  ? 140  LYS A C     1 ? 
ATOM   1074 O O     . LYS A 1 161 ? -2.314  9.758   6.681  1.00 29.78  ? 140  LYS A O     1 ? 
ATOM   1075 C CB    . LYS A 1 161 ? -4.055  11.677  8.379  1.00 28.29  ? 140  LYS A CB    1 ? 
ATOM   1076 C CG    . LYS A 1 161 ? -4.534  13.095  8.356  1.00 27.21  ? 140  LYS A CG    1 ? 
ATOM   1077 C CD    . LYS A 1 161 ? -3.711  14.024  7.492  1.00 26.73  ? 140  LYS A CD    1 ? 
ATOM   1078 C CE    . LYS A 1 161 ? -4.279  15.388  7.593  1.00 29.92  ? 140  LYS A CE    1 ? 
ATOM   1079 N NZ    . LYS A 1 161 ? -3.593  16.219  6.600  1.00 30.61  ? 140  LYS A NZ    1 ? 
ATOM   1080 N N     . VAL A 1 162 ? -3.970  8.542   7.612  1.00 28.47  ? 141  VAL A N     1 ? 
ATOM   1081 C CA    . VAL A 1 162 ? -3.112  7.388   7.871  1.00 26.81  ? 141  VAL A CA    1 ? 
ATOM   1082 C C     . VAL A 1 162 ? -3.372  6.297   6.846  1.00 25.81  ? 141  VAL A C     1 ? 
ATOM   1083 O O     . VAL A 1 162 ? -4.409  5.636   6.889  1.00 27.55  ? 141  VAL A O     1 ? 
ATOM   1084 C CB    . VAL A 1 162 ? -3.292  6.824   9.293  1.00 26.96  ? 141  VAL A CB    1 ? 
ATOM   1085 C CG1   . VAL A 1 162 ? -2.296  5.694   9.543  1.00 29.14  ? 141  VAL A CG1   1 ? 
ATOM   1086 C CG2   . VAL A 1 162 ? -3.172  7.924   10.351 1.00 28.69  ? 141  VAL A CG2   1 ? 
ATOM   1087 N N     . LYS A 1 163 ? -2.399  6.081   5.960  1.00 26.64  ? 142  LYS A N     1 ? 
ATOM   1088 C CA    . LYS A 1 163 ? -2.499  5.050   4.934  1.00 27.67  ? 142  LYS A CA    1 ? 
ATOM   1089 C C     . LYS A 1 163 ? -2.372  3.676   5.581  1.00 27.44  ? 142  LYS A C     1 ? 
ATOM   1090 O O     . LYS A 1 163 ? -1.415  3.427   6.313  1.00 26.88  ? 142  LYS A O     1 ? 
ATOM   1091 C CB    . LYS A 1 163 ? -1.405  5.190   3.875  1.00 30.34  ? 142  LYS A CB    1 ? 
ATOM   1092 C CG    . LYS A 1 163 ? -1.364  4.081   2.822  1.00 39.22  ? 142  LYS A CG    1 ? 
ATOM   1093 C CD    . LYS A 1 163 ? -2.550  4.053   1.854  1.00 42.34  ? 142  LYS A CD    1 ? 
ATOM   1094 C CE    . LYS A 1 163 ? -2.489  2.861   0.968  1.00 44.38  ? 142  LYS A CE    1 ? 
ATOM   1095 N NZ    . LYS A 1 163 ? -3.462  2.914   -0.125 1.00 48.18  ? 142  LYS A NZ    1 ? 
ATOM   1096 N N     . LEU A 1 164 ? -3.308  2.794   5.227  1.00 26.82  ? 143  LEU A N     1 ? 
ATOM   1097 C CA    . LEU A 1 164 ? -3.373  1.429   5.718  1.00 27.69  ? 143  LEU A CA    1 ? 
ATOM   1098 C C     . LEU A 1 164 ? -3.329  0.483   4.522  1.00 29.86  ? 143  LEU A C     1 ? 
ATOM   1099 O O     . LEU A 1 164 ? -4.066  0.689   3.556  1.00 28.05  ? 143  LEU A O     1 ? 
ATOM   1100 C CB    . LEU A 1 164 ? -4.663  1.266   6.512  1.00 24.96  ? 143  LEU A CB    1 ? 
ATOM   1101 C CG    . LEU A 1 164 ? -4.835  2.194   7.719  1.00 26.10  ? 143  LEU A CG    1 ? 
ATOM   1102 C CD1   . LEU A 1 164 ? -6.204  1.971   8.322  1.00 30.26  ? 143  LEU A CD1   1 ? 
ATOM   1103 C CD2   . LEU A 1 164 ? -3.742  2.015   8.753  1.00 25.75  ? 143  LEU A CD2   1 ? 
ATOM   1104 N N     . THR A 1 165 ? -2.471  -0.540  4.610  1.00 27.81  ? 144  THR A N     1 ? 
ATOM   1105 C CA    . THR A 1 165 ? -2.295  -1.534  3.556  1.00 30.37  ? 144  THR A CA    1 ? 
ATOM   1106 C C     . THR A 1 165 ? -2.337  -2.926  4.176  1.00 31.86  ? 144  THR A C     1 ? 
ATOM   1107 O O     . THR A 1 165 ? -1.931  -3.130  5.321  1.00 29.61  ? 144  THR A O     1 ? 
ATOM   1108 C CB    . THR A 1 165 ? -0.983  -1.324  2.799  1.00 28.06  ? 144  THR A CB    1 ? 
ATOM   1109 O OG1   . THR A 1 165 ? 0.044   -1.210  3.776  1.00 30.66  ? 144  THR A OG1   1 ? 
ATOM   1110 C CG2   . THR A 1 165 ? -0.901  -0.002  2.065  1.00 29.14  ? 144  THR A CG2   1 ? 
ATOM   1111 N N     . ASP A 1 166 ? -2.832  -3.888  3.395  1.00 33.18  ? 145  ASP A N     1 ? 
ATOM   1112 C CA    . ASP A 1 166 ? -2.854  -5.288  3.793  1.00 30.69  ? 145  ASP A CA    1 ? 
ATOM   1113 C C     . ASP A 1 166 ? -1.443  -5.759  4.093  1.00 31.04  ? 145  ASP A C     1 ? 
ATOM   1114 O O     . ASP A 1 166 ? -0.507  -5.345  3.422  1.00 29.71  ? 145  ASP A O     1 ? 
ATOM   1115 C CB    . ASP A 1 166 ? -3.406  -6.159  2.680  1.00 34.10  ? 145  ASP A CB    1 ? 
ATOM   1116 C CG    . ASP A 1 166 ? -4.876  -5.947  2.363  1.00 38.25  ? 145  ASP A CG    1 ? 
ATOM   1117 O OD1   . ASP A 1 166 ? -5.535  -5.161  3.081  1.00 36.37  ? 145  ASP A OD1   1 ? 
ATOM   1118 O OD2   . ASP A 1 166 ? -5.357  -6.591  1.427  1.00 40.04  ? 145  ASP A OD2   1 ? 
ATOM   1119 N N     . SER A 1 167 ? -1.291  -6.575  5.141  1.00 25.91  ? 146  SER A N     1 ? 
ATOM   1120 C CA    . SER A 1 167 ? -0.024  -7.230  5.415  1.00 26.69  ? 146  SER A CA    1 ? 
ATOM   1121 C C     . SER A 1 167 ? 0.455   -7.951  4.157  1.00 27.91  ? 146  SER A C     1 ? 
ATOM   1122 O O     . SER A 1 167 ? -0.342  -8.633  3.503  1.00 26.42  ? 146  SER A O     1 ? 
ATOM   1123 C CB    . SER A 1 167 ? -0.149  -8.227  6.551  1.00 27.87  ? 146  SER A CB    1 ? 
ATOM   1124 O OG    . SER A 1 167 ? -0.578  -7.603  7.758  1.00 24.83  ? 146  SER A OG    1 ? 
ATOM   1125 N N     . SER A 1 168 ? 1.756   -7.840  3.865  1.00 29.99  ? 147  SER A N     1 ? 
ATOM   1126 C CA    . SER A 1 168 ? 2.320   -8.610  2.772  1.00 35.21  ? 147  SER A CA    1 ? 
ATOM   1127 C C     . SER A 1 168 ? 2.714   -9.985  3.302  1.00 36.56  ? 147  SER A C     1 ? 
ATOM   1128 O O     . SER A 1 168 ? 3.088   -10.144 4.471  1.00 31.67  ? 147  SER A O     1 ? 
ATOM   1129 C CB    . SER A 1 168 ? 3.430   -7.855  2.059  1.00 36.99  ? 147  SER A CB    1 ? 
ATOM   1130 O OG    . SER A 1 168 ? 4.451   -7.430  2.942  1.00 47.39  ? 147  SER A OG    1 ? 
ATOM   1131 N N     . TYR A 1 169 ? 2.521   -11.016 2.473  1.00 35.27  ? 148  TYR A N     1 ? 
ATOM   1132 C CA    . TYR A 1 169 ? 2.889   -12.365 2.873  1.00 34.52  ? 148  TYR A CA    1 ? 
ATOM   1133 C C     . TYR A 1 169 ? 3.336   -13.163 1.646  1.00 38.45  ? 148  TYR A C     1 ? 
ATOM   1134 O O     . TYR A 1 169 ? 2.872   -12.905 0.540  1.00 34.59  ? 148  TYR A O     1 ? 
ATOM   1135 C CB    . TYR A 1 169 ? 1.723   -13.056 3.577  1.00 37.49  ? 148  TYR A CB    1 ? 
ATOM   1136 C CG    . TYR A 1 169 ? 0.437   -13.102 2.762  1.00 41.67  ? 148  TYR A CG    1 ? 
ATOM   1137 C CD1   . TYR A 1 169 ? -0.499  -12.074 2.801  1.00 45.43  ? 148  TYR A CD1   1 ? 
ATOM   1138 C CD2   . TYR A 1 169 ? 0.181   -14.181 1.925  1.00 45.92  ? 148  TYR A CD2   1 ? 
ATOM   1139 C CE1   . TYR A 1 169 ? -1.660  -12.127 2.045  1.00 48.05  ? 148  TYR A CE1   1 ? 
ATOM   1140 C CE2   . TYR A 1 169 ? -0.968  -14.244 1.159  1.00 45.91  ? 148  TYR A CE2   1 ? 
ATOM   1141 C CZ    . TYR A 1 169 ? -1.885  -13.212 1.212  1.00 48.09  ? 148  TYR A CZ    1 ? 
ATOM   1142 O OH    . TYR A 1 169 ? -2.994  -13.325 0.442  1.00 46.72  ? 148  TYR A OH    1 ? 
ATOM   1143 N N     . PRO A 1 170 ? 4.248   -14.147 1.817  1.00 39.41  ? 149  PRO A N     1 ? 
ATOM   1144 C CA    . PRO A 1 170 ? 4.766   -14.921 0.693  1.00 37.60  ? 149  PRO A CA    1 ? 
ATOM   1145 C C     . PRO A 1 170 ? 4.047   -16.203 0.325  1.00 39.42  ? 149  PRO A C     1 ? 
ATOM   1146 O O     . PRO A 1 170 ? 4.391   -16.806 -0.689 1.00 44.59  ? 149  PRO A O     1 ? 
ATOM   1147 C CB    . PRO A 1 170 ? 6.156   -15.229 1.229  1.00 38.58  ? 149  PRO A CB    1 ? 
ATOM   1148 C CG    . PRO A 1 170 ? 5.903   -15.549 2.678  1.00 41.54  ? 149  PRO A CG    1 ? 
ATOM   1149 C CD    . PRO A 1 170 ? 4.896   -14.496 3.095  1.00 40.35  ? 149  PRO A CD    1 ? 
ATOM   1150 N N     . THR A 1 171 ? 3.086   -16.625 1.152  1.00 38.38  ? 150  THR A N     1 ? 
ATOM   1151 C CA    . THR A 1 171 ? 2.585   -17.984 1.060  1.00 36.82  ? 150  THR A CA    1 ? 
ATOM   1152 C C     . THR A 1 171 ? 1.078   -18.011 0.841  1.00 38.80  ? 150  THR A C     1 ? 
ATOM   1153 O O     . THR A 1 171 ? 0.330   -17.285 1.490  1.00 39.57  ? 150  THR A O     1 ? 
ATOM   1154 C CB    . THR A 1 171 ? 2.967   -18.784 2.300  1.00 39.99  ? 150  THR A CB    1 ? 
ATOM   1155 O OG1   . THR A 1 171 ? 2.470   -20.085 2.012  1.00 34.81  ? 150  THR A OG1   1 ? 
ATOM   1156 C CG2   . THR A 1 171 ? 2.324   -18.244 3.573  1.00 35.83  ? 150  THR A CG2   1 ? 
ATOM   1157 N N     . PRO A 1 172 ? 0.584   -18.883 -0.074 1.00 40.60  ? 151  PRO A N     1 ? 
ATOM   1158 C CA    . PRO A 1 172 ? -0.859  -19.056 -0.265 1.00 38.35  ? 151  PRO A CA    1 ? 
ATOM   1159 C C     . PRO A 1 172 ? -1.527  -19.734 0.925  1.00 31.98  ? 151  PRO A C     1 ? 
ATOM   1160 O O     . PRO A 1 172 ? -2.750  -19.722 1.060  1.00 31.33  ? 151  PRO A O     1 ? 
ATOM   1161 C CB    . PRO A 1 172 ? -0.948  -19.898 -1.578 1.00 43.43  ? 151  PRO A CB    1 ? 
ATOM   1162 C CG    . PRO A 1 172 ? 0.368   -20.653 -1.628 1.00 42.50  ? 151  PRO A CG    1 ? 
ATOM   1163 C CD    . PRO A 1 172 ? 1.392   -19.716 -0.993 1.00 39.35  ? 151  PRO A CD    1 ? 
ATOM   1164 N N     . PHE A 1 173 ? -0.720  -20.286 1.838  1.00 36.52  ? 152  PHE A N     1 ? 
ATOM   1165 C CA    . PHE A 1 173 ? -1.247  -20.941 3.030  1.00 33.97  ? 152  PHE A CA    1 ? 
ATOM   1166 C C     . PHE A 1 173 ? -2.091  -19.993 3.894  1.00 32.77  ? 152  PHE A C     1 ? 
ATOM   1167 O O     . PHE A 1 173 ? -2.893  -20.451 4.713  1.00 33.55  ? 152  PHE A O     1 ? 
ATOM   1168 C CB    . PHE A 1 173 ? -0.062  -21.520 3.817  1.00 38.54  ? 152  PHE A CB    1 ? 
ATOM   1169 C CG    . PHE A 1 173 ? -0.486  -22.281 5.063  1.00 37.80  ? 152  PHE A CG    1 ? 
ATOM   1170 C CD1   . PHE A 1 173 ? -0.982  -23.578 4.979  1.00 38.32  ? 152  PHE A CD1   1 ? 
ATOM   1171 C CD2   . PHE A 1 173 ? -0.374  -21.697 6.321  1.00 40.11  ? 152  PHE A CD2   1 ? 
ATOM   1172 C CE1   . PHE A 1 173 ? -1.363  -24.271 6.114  1.00 39.16  ? 152  PHE A CE1   1 ? 
ATOM   1173 C CE2   . PHE A 1 173 ? -0.765  -22.384 7.456  1.00 36.43  ? 152  PHE A CE2   1 ? 
ATOM   1174 C CZ    . PHE A 1 173 ? -1.272  -23.664 7.354  1.00 44.92  ? 152  PHE A CZ    1 ? 
ATOM   1175 N N     . VAL A 1 174 ? -1.959  -18.668 3.707  1.00 36.45  ? 153  VAL A N     1 ? 
ATOM   1176 C CA    . VAL A 1 174 ? -2.786  -17.737 4.473  1.00 38.08  ? 153  VAL A CA    1 ? 
ATOM   1177 C C     . VAL A 1 174 ? -4.264  -18.067 4.251  1.00 36.88  ? 153  VAL A C     1 ? 
ATOM   1178 O O     . VAL A 1 174 ? -5.057  -18.022 5.192  1.00 31.65  ? 153  VAL A O     1 ? 
ATOM   1179 C CB    . VAL A 1 174 ? -2.442  -16.264 4.185  1.00 40.11  ? 153  VAL A CB    1 ? 
ATOM   1180 C CG1   . VAL A 1 174 ? -3.435  -15.294 4.810  1.00 46.08  ? 153  VAL A CG1   1 ? 
ATOM   1181 C CG2   . VAL A 1 174 ? -1.037  -15.942 4.678  1.00 43.86  ? 153  VAL A CG2   1 ? 
ATOM   1182 N N     . HIS A 1 175 ? -4.621  -18.479 3.024  1.00 38.29  ? 154  HIS A N     1 ? 
ATOM   1183 C CA    . HIS A 1 175 ? -6.004  -18.812 2.688  1.00 38.31  ? 154  HIS A CA    1 ? 
ATOM   1184 C C     . HIS A 1 175 ? -6.492  -20.014 3.498  1.00 31.18  ? 154  HIS A C     1 ? 
ATOM   1185 O O     . HIS A 1 175 ? -7.632  -20.013 3.958  1.00 37.61  ? 154  HIS A O     1 ? 
ATOM   1186 C CB    . HIS A 1 175 ? -6.148  -19.026 1.171  1.00 41.64  ? 154  HIS A CB    1 ? 
ATOM   1187 C CG    . HIS A 1 175 ? -5.793  -17.795 0.409  1.00 41.41  ? 154  HIS A CG    1 ? 
ATOM   1188 N ND1   . HIS A 1 175 ? -6.646  -16.714 0.412  1.00 45.54  ? 154  HIS A ND1   1 ? 
ATOM   1189 C CD2   . HIS A 1 175 ? -4.712  -17.423 -0.283 1.00 43.26  ? 154  HIS A CD2   1 ? 
ATOM   1190 C CE1   . HIS A 1 175 ? -6.096  -15.729 -0.271 1.00 42.73  ? 154  HIS A CE1   1 ? 
ATOM   1191 N NE2   . HIS A 1 175 ? -4.921  -16.133 -0.689 1.00 44.46  ? 154  HIS A NE2   1 ? 
ATOM   1192 N N     . THR A 1 176 ? -5.616  -21.027 3.684  1.00 31.81  ? 155  THR A N     1 ? 
ATOM   1193 C CA    . THR A 1 176 ? -5.925  -22.215 4.474  1.00 31.81  ? 155  THR A CA    1 ? 
ATOM   1194 C C     . THR A 1 176 ? -6.250  -21.860 5.932  1.00 32.06  ? 155  THR A C     1 ? 
ATOM   1195 O O     . THR A 1 176 ? -7.122  -22.470 6.550  1.00 31.98  ? 155  THR A O     1 ? 
ATOM   1196 C CB    . THR A 1 176 ? -4.731  -23.166 4.399  1.00 37.60  ? 155  THR A CB    1 ? 
ATOM   1197 O OG1   . THR A 1 176 ? -4.246  -23.199 3.062  1.00 39.47  ? 155  THR A OG1   1 ? 
ATOM   1198 C CG2   . THR A 1 176 ? -5.074  -24.559 4.883  1.00 38.71  ? 155  THR A CG2   1 ? 
ATOM   1199 N N     . LEU A 1 177 ? -5.563  -20.844 6.485  1.00 36.67  ? 156  LEU A N     1 ? 
ATOM   1200 C CA    . LEU A 1 177 ? -5.811  -20.412 7.860  1.00 34.26  ? 156  LEU A CA    1 ? 
ATOM   1201 C C     . LEU A 1 177 ? -7.194  -19.770 7.953  1.00 30.35  ? 156  LEU A C     1 ? 
ATOM   1202 O O     . LEU A 1 177 ? -7.960  -20.050 8.880  1.00 36.04  ? 156  LEU A O     1 ? 
ATOM   1203 C CB    . LEU A 1 177 ? -4.695  -19.462 8.305  1.00 31.52  ? 156  LEU A CB    1 ? 
ATOM   1204 C CG    . LEU A 1 177 ? -3.309  -20.092 8.445  1.00 30.21  ? 156  LEU A CG    1 ? 
ATOM   1205 C CD1   . LEU A 1 177 ? -2.198  -19.072 8.484  1.00 31.67  ? 156  LEU A CD1   1 ? 
ATOM   1206 C CD2   . LEU A 1 177 ? -3.304  -20.985 9.678  1.00 30.71  ? 156  LEU A CD2   1 ? 
ATOM   1207 N N     . LEU A 1 178 ? -7.509  -18.918 6.975  1.00 31.57  ? 157  LEU A N     1 ? 
ATOM   1208 C CA    . LEU A 1 178 ? -8.784  -18.219 6.959  1.00 31.34  ? 157  LEU A CA    1 ? 
ATOM   1209 C C     . LEU A 1 178 ? -9.912  -19.244 6.860  1.00 34.26  ? 157  LEU A C     1 ? 
ATOM   1210 O O     . LEU A 1 178 ? -10.906 -19.151 7.575  1.00 32.81  ? 157  LEU A O     1 ? 
ATOM   1211 C CB    . LEU A 1 178 ? -8.880  -17.190 5.831  1.00 33.78  ? 157  LEU A CB    1 ? 
ATOM   1212 C CG    . LEU A 1 178 ? -7.838  -16.064 5.779  1.00 38.66  ? 157  LEU A CG    1 ? 
ATOM   1213 C CD1   . LEU A 1 178 ? -8.266  -14.926 4.886  1.00 38.12  ? 157  LEU A CD1   1 ? 
ATOM   1214 C CD2   . LEU A 1 178 ? -7.521  -15.528 7.144  1.00 40.79  ? 157  LEU A CD2   1 ? 
ATOM   1215 N N     . ASN A 1 179 ? -9.752  -20.234 5.968  1.00 39.31  ? 158  ASN A N     1 ? 
ATOM   1216 C CA    . ASN A 1 179 ? -10.764 -21.267 5.755  1.00 39.55  ? 158  ASN A CA    1 ? 
ATOM   1217 C C     . ASN A 1 179 ? -10.933 -22.108 7.009  1.00 35.83  ? 158  ASN A C     1 ? 
ATOM   1218 O O     . ASN A 1 179 ? -12.050 -22.458 7.374  1.00 38.21  ? 158  ASN A O     1 ? 
ATOM   1219 C CB    . ASN A 1 179 ? -10.416 -22.156 4.560  1.00 41.79  ? 158  ASN A CB    1 ? 
ATOM   1220 C CG    . ASN A 1 179 ? -10.451 -21.390 3.256  1.00 43.54  ? 158  ASN A CG    1 ? 
ATOM   1221 O OD1   . ASN A 1 179 ? -11.163 -20.389 3.126  1.00 48.42  ? 158  ASN A OD1   1 ? 
ATOM   1222 N ND2   . ASN A 1 179 ? -9.709  -21.841 2.259  1.00 48.31  ? 158  ASN A ND2   1 ? 
ATOM   1223 N N     . GLY A 1 180 ? -9.812  -22.417 7.676  1.00 35.49  ? 159  GLY A N     1 ? 
ATOM   1224 C CA    . GLY A 1 180 ? -9.852  -23.169 8.924  1.00 30.85  ? 159  GLY A CA    1 ? 
ATOM   1225 C C     . GLY A 1 180 ? -10.690 -22.512 10.011 1.00 30.27  ? 159  GLY A C     1 ? 
ATOM   1226 O O     . GLY A 1 180 ? -11.418 -23.184 10.738 1.00 33.59  ? 159  GLY A O     1 ? 
ATOM   1227 N N     . PHE A 1 181 ? -10.551 -21.190 10.168 1.00 36.63  ? 160  PHE A N     1 ? 
ATOM   1228 C CA    . PHE A 1 181 ? -11.341 -20.440 11.136 1.00 31.65  ? 160  PHE A CA    1 ? 
ATOM   1229 C C     . PHE A 1 181 ? -12.828 -20.574 10.791 1.00 33.10  ? 160  PHE A C     1 ? 
ATOM   1230 O O     . PHE A 1 181 ? -13.668 -20.771 11.660 1.00 32.90  ? 160  PHE A O     1 ? 
ATOM   1231 C CB    . PHE A 1 181 ? -10.822 -18.997 11.075 1.00 32.33  ? 160  PHE A CB    1 ? 
ATOM   1232 C CG    . PHE A 1 181 ? -11.554 -17.978 11.928 1.00 30.55  ? 160  PHE A CG    1 ? 
ATOM   1233 C CD1   . PHE A 1 181 ? -12.722 -17.380 11.485 1.00 32.07  ? 160  PHE A CD1   1 ? 
ATOM   1234 C CD2   . PHE A 1 181 ? -11.017 -17.552 13.144 1.00 29.59  ? 160  PHE A CD2   1 ? 
ATOM   1235 C CE1   . PHE A 1 181 ? -13.368 -16.423 12.254 1.00 28.63  ? 160  PHE A CE1   1 ? 
ATOM   1236 C CE2   . PHE A 1 181 ? -11.673 -16.613 13.919 1.00 28.23  ? 160  PHE A CE2   1 ? 
ATOM   1237 C CZ    . PHE A 1 181 ? -12.828 -16.027 13.466 1.00 28.68  ? 160  PHE A CZ    1 ? 
ATOM   1238 N N     . LYS A 1 182 ? -13.171 -20.418 9.512  1.00 38.88  ? 161  LYS A N     1 ? 
ATOM   1239 C CA    . LYS A 1 182 ? -14.571 -20.532 9.116  1.00 39.99  ? 161  LYS A CA    1 ? 
ATOM   1240 C C     . LYS A 1 182 ? -15.077 -21.953 9.356  1.00 36.50  ? 161  LYS A C     1 ? 
ATOM   1241 O O     . LYS A 1 182 ? -16.111 -22.139 9.989  1.00 33.07  ? 161  LYS A O     1 ? 
ATOM   1242 C CB    . LYS A 1 182 ? -14.793 -20.100 7.671  1.00 43.25  ? 161  LYS A CB    1 ? 
ATOM   1243 C CG    . LYS A 1 182 ? -16.260 -20.088 7.298  1.00 47.54  ? 161  LYS A CG    1 ? 
ATOM   1244 C CD    . LYS A 1 182 ? -16.482 -19.551 5.897  1.00 56.22  ? 161  LYS A CD    1 ? 
ATOM   1245 C CE    . LYS A 1 182 ? -17.936 -19.407 5.570  1.00 64.51  ? 161  LYS A CE    1 ? 
ATOM   1246 N NZ    . LYS A 1 182 ? -18.053 -18.541 4.395  1.00 66.58  ? 161  LYS A NZ    1 ? 
ATOM   1247 N N     . GLU A 1 183 ? -14.304 -22.949 8.914  1.00 38.59  ? 162  GLU A N     1 ? 
ATOM   1248 C CA    . GLU A 1 183 ? -14.681 -24.345 9.076  1.00 40.15  ? 162  GLU A CA    1 ? 
ATOM   1249 C C     . GLU A 1 183 ? -14.871 -24.718 10.540 1.00 43.75  ? 162  GLU A C     1 ? 
ATOM   1250 O O     . GLU A 1 183 ? -15.720 -25.558 10.842 1.00 40.93  ? 162  GLU A O     1 ? 
ATOM   1251 C CB    . GLU A 1 183 ? -13.648 -25.295 8.482  1.00 41.27  ? 162  GLU A CB    1 ? 
ATOM   1252 C CG    . GLU A 1 183 ? -13.578 -25.206 6.963  1.00 40.11  ? 162  GLU A CG    1 ? 
ATOM   1253 C CD    . GLU A 1 183 ? -12.331 -25.868 6.426  1.00 44.88  ? 162  GLU A CD    1 ? 
ATOM   1254 O OE1   . GLU A 1 183 ? -11.936 -25.541 5.282  1.00 42.12  ? 162  GLU A OE1   1 ? 
ATOM   1255 O OE2   . GLU A 1 183 ? -11.747 -26.707 7.161  1.00 49.69  ? 162  GLU A OE2   1 ? 
ATOM   1256 N N     . ALA A 1 184 ? -14.121 -24.073 11.451 1.00 41.69  ? 163  ALA A N     1 ? 
ATOM   1257 C CA    . ALA A 1 184 ? -14.221 -24.405 12.861 1.00 36.69  ? 163  ALA A CA    1 ? 
ATOM   1258 C C     . ALA A 1 184 ? -15.489 -23.832 13.469 1.00 34.50  ? 163  ALA A C     1 ? 
ATOM   1259 O O     . ALA A 1 184 ? -15.798 -24.160 14.614 1.00 39.59  ? 163  ALA A O     1 ? 
ATOM   1260 C CB    . ALA A 1 184 ? -13.003 -23.936 13.631 1.00 42.50  ? 163  ALA A CB    1 ? 
ATOM   1261 N N     . GLY A 1 185 ? -16.197 -22.957 12.745 1.00 33.53  ? 164  GLY A N     1 ? 
ATOM   1262 C CA    . GLY A 1 185 ? -17.369 -22.296 13.312 1.00 34.86  ? 164  GLY A CA    1 ? 
ATOM   1263 C C     . GLY A 1 185 ? -17.044 -21.041 14.138 1.00 34.14  ? 164  GLY A C     1 ? 
ATOM   1264 O O     . GLY A 1 185 ? -17.876 -20.567 14.907 1.00 34.67  ? 164  GLY A O     1 ? 
ATOM   1265 N N     . PHE A 1 186 ? -15.851 -20.474 13.959 1.00 37.04  ? 165  PHE A N     1 ? 
ATOM   1266 C CA    . PHE A 1 186 ? -15.425 -19.323 14.751 1.00 35.43  ? 165  PHE A CA    1 ? 
ATOM   1267 C C     . PHE A 1 186 ? -16.114 -18.044 14.277 1.00 36.59  ? 165  PHE A C     1 ? 
ATOM   1268 O O     . PHE A 1 186 ? -16.248 -17.111 15.060 1.00 36.81  ? 165  PHE A O     1 ? 
ATOM   1269 C CB    . PHE A 1 186 ? -13.903 -19.177 14.678 1.00 29.81  ? 165  PHE A CB    1 ? 
ATOM   1270 C CG    . PHE A 1 186 ? -13.120 -20.253 15.407 1.00 28.17  ? 165  PHE A CG    1 ? 
ATOM   1271 C CD1   . PHE A 1 186 ? -13.754 -21.160 16.251 1.00 35.23  ? 165  PHE A CD1   1 ? 
ATOM   1272 C CD2   . PHE A 1 186 ? -11.739 -20.343 15.269 1.00 28.44  ? 165  PHE A CD2   1 ? 
ATOM   1273 C CE1   . PHE A 1 186 ? -13.016 -22.128 16.926 1.00 33.84  ? 165  PHE A CE1   1 ? 
ATOM   1274 C CE2   . PHE A 1 186 ? -11.010 -21.315 15.941 1.00 27.58  ? 165  PHE A CE2   1 ? 
ATOM   1275 C CZ    . PHE A 1 186 ? -11.650 -22.202 16.758 1.00 28.57  ? 165  PHE A CZ    1 ? 
ATOM   1276 N N     . GLY A 1 187 ? -16.535 -18.018 13.007 1.00 36.22  ? 166  GLY A N     1 ? 
ATOM   1277 C CA    . GLY A 1 187 ? -17.133 -16.842 12.389 1.00 37.62  ? 166  GLY A CA    1 ? 
ATOM   1278 C C     . GLY A 1 187 ? -16.810 -16.781 10.895 1.00 37.19  ? 166  GLY A C     1 ? 
ATOM   1279 O O     . GLY A 1 187 ? -16.461 -17.789 10.279 1.00 38.13  ? 166  GLY A O     1 ? 
ATOM   1280 N N     . GLU A 1 188 ? -16.892 -15.582 10.315 1.00 39.36  ? 167  GLU A N     1 ? 
ATOM   1281 C CA    . GLU A 1 188 ? -16.805 -15.432 8.874  1.00 37.67  ? 167  GLU A CA    1 ? 
ATOM   1282 C C     . GLU A 1 188 ? -15.438 -14.895 8.494  1.00 40.42  ? 167  GLU A C     1 ? 
ATOM   1283 O O     . GLU A 1 188 ? -14.655 -14.482 9.348  1.00 39.46  ? 167  GLU A O     1 ? 
ATOM   1284 C CB    . GLU A 1 188 ? -17.878 -14.462 8.371  1.00 44.20  ? 167  GLU A CB    1 ? 
ATOM   1285 C CG    . GLU A 1 188 ? -19.315 -14.911 8.635  1.00 46.98  ? 167  GLU A CG    1 ? 
ATOM   1286 C CD    . GLU A 1 188 ? -19.711 -16.222 7.969  1.00 48.96  ? 167  GLU A CD    1 ? 
ATOM   1287 O OE1   . GLU A 1 188 ? -20.337 -17.043 8.661  1.00 50.48  ? 167  GLU A OE1   1 ? 
ATOM   1288 O OE2   . GLU A 1 188 ? -19.377 -16.443 6.786  1.00 52.64  ? 167  GLU A OE2   1 ? 
ATOM   1289 N N     . ILE A 1 189 ? -15.175 -14.922 7.189  1.00 34.66  ? 168  ILE A N     1 ? 
ATOM   1290 C CA    . ILE A 1 189 ? -14.006 -14.311 6.603  1.00 36.07  ? 168  ILE A CA    1 ? 
ATOM   1291 C C     . ILE A 1 189 ? -14.415 -12.933 6.104  1.00 41.83  ? 168  ILE A C     1 ? 
ATOM   1292 O O     . ILE A 1 189 ? -15.282 -12.837 5.247  1.00 37.50  ? 168  ILE A O     1 ? 
ATOM   1293 C CB    . ILE A 1 189 ? -13.436 -15.168 5.460  1.00 35.01  ? 168  ILE A CB    1 ? 
ATOM   1294 C CG1   . ILE A 1 189 ? -13.064 -16.589 5.948  1.00 40.02  ? 168  ILE A CG1   1 ? 
ATOM   1295 C CG2   . ILE A 1 189 ? -12.278 -14.445 4.778  1.00 30.39  ? 168  ILE A CG2   1 ? 
ATOM   1296 C CD1   . ILE A 1 189 ? -12.691 -17.558 4.838  1.00 39.61  ? 168  ILE A CD1   1 ? 
ATOM   1297 N N     . GLY A 1 190 ? -13.745 -11.881 6.594  1.00 37.84  ? 169  GLY A N     1 ? 
ATOM   1298 C CA    . GLY A 1 190 ? -14.149 -10.516 6.284  1.00 38.72  ? 169  GLY A CA    1 ? 
ATOM   1299 C C     . GLY A 1 190 ? -13.690 -9.542  7.363  1.00 37.46  ? 169  GLY A C     1 ? 
ATOM   1300 O O     . GLY A 1 190 ? -12.913 -9.910  8.241  1.00 32.53  ? 169  GLY A O     1 ? 
ATOM   1301 N N     . ASP A 1 191 ? -14.214 -8.315  7.300  1.00 35.95  ? 170  ASP A N     1 ? 
ATOM   1302 C CA    . ASP A 1 191 ? -13.621 -7.181  7.993  1.00 34.14  ? 170  ASP A CA    1 ? 
ATOM   1303 C C     . ASP A 1 191 ? -14.143 -7.123  9.426  1.00 30.60  ? 170  ASP A C     1 ? 
ATOM   1304 O O     . ASP A 1 191 ? -15.272 -6.748  9.668  1.00 30.40  ? 170  ASP A O     1 ? 
ATOM   1305 C CB    . ASP A 1 191 ? -13.916 -5.902  7.231  1.00 39.65  ? 170  ASP A CB    1 ? 
ATOM   1306 C CG    . ASP A 1 191 ? -13.499 -4.619  7.931  1.00 37.97  ? 170  ASP A CG    1 ? 
ATOM   1307 O OD1   . ASP A 1 191 ? -12.526 -4.691  8.735  1.00 33.08  ? 170  ASP A OD1   1 ? 
ATOM   1308 O OD2   . ASP A 1 191 ? -14.192 -3.592  7.697  1.00 33.34  ? 170  ASP A OD2   1 ? 
ATOM   1309 N N     . TYR A 1 192 ? -13.302 -7.490  10.399 1.00 29.58  ? 171  TYR A N     1 ? 
ATOM   1310 C CA    . TYR A 1 192 ? -13.716 -7.517  11.796 1.00 27.61  ? 171  TYR A CA    1 ? 
ATOM   1311 C C     . TYR A 1 192 ? -14.030 -6.111  12.318 1.00 25.59  ? 171  TYR A C     1 ? 
ATOM   1312 O O     . TYR A 1 192 ? -14.670 -5.986  13.345 1.00 29.65  ? 171  TYR A O     1 ? 
ATOM   1313 C CB    . TYR A 1 192 ? -12.653 -8.236  12.642 1.00 27.58  ? 171  TYR A CB    1 ? 
ATOM   1314 C CG    . TYR A 1 192 ? -11.220 -7.916  12.229 1.00 24.64  ? 171  TYR A CG    1 ? 
ATOM   1315 C CD1   . TYR A 1 192 ? -10.696 -6.640  12.404 1.00 24.64  ? 171  TYR A CD1   1 ? 
ATOM   1316 C CD2   . TYR A 1 192 ? -10.387 -8.902  11.708 1.00 24.14  ? 171  TYR A CD2   1 ? 
ATOM   1317 C CE1   . TYR A 1 192 ? -9.409  -6.333  11.988 1.00 24.53  ? 171  TYR A CE1   1 ? 
ATOM   1318 C CE2   . TYR A 1 192 ? -9.085  -8.624  11.345 1.00 26.36  ? 171  TYR A CE2   1 ? 
ATOM   1319 C CZ    . TYR A 1 192 ? -8.590  -7.340  11.501 1.00 26.86  ? 171  TYR A CZ    1 ? 
ATOM   1320 O OH    . TYR A 1 192 ? -7.317  -7.067  11.104 1.00 24.25  ? 171  TYR A OH    1 ? 
ATOM   1321 N N     . ALA A 1 193 ? -13.555 -5.066  11.641 1.00 29.65  ? 172  ALA A N     1 ? 
ATOM   1322 C CA    . ALA A 1 193 ? -13.805 -3.685  12.022 1.00 34.03  ? 172  ALA A CA    1 ? 
ATOM   1323 C C     . ALA A 1 193 ? -14.983 -3.110  11.230 1.00 39.49  ? 172  ALA A C     1 ? 
ATOM   1324 O O     . ALA A 1 193 ? -15.199 -1.900  11.248 1.00 37.51  ? 172  ALA A O     1 ? 
ATOM   1325 C CB    . ALA A 1 193 ? -12.555 -2.855  11.784 1.00 33.64  ? 172  ALA A CB    1 ? 
ATOM   1326 N N     . GLY A 1 194 ? -15.735 -3.991  10.552 1.00 43.82  ? 173  GLY A N     1 ? 
ATOM   1327 C CA    . GLY A 1 194 ? -16.892 -3.607  9.750  1.00 47.07  ? 173  GLY A CA    1 ? 
ATOM   1328 C C     . GLY A 1 194 ? -18.204 -4.006  10.431 1.00 45.36  ? 173  GLY A C     1 ? 
ATOM   1329 O O     . GLY A 1 194 ? -18.343 -3.897  11.655 1.00 38.18  ? 173  GLY A O     1 ? 
ATOM   1330 N N     . GLU A 1 195 ? -19.155 -4.502  9.628  1.00 50.38  ? 174  GLU A N     1 ? 
ATOM   1331 C CA    . GLU A 1 195 ? -20.474 -4.847  10.138 1.00 52.45  ? 174  GLU A CA    1 ? 
ATOM   1332 C C     . GLU A 1 195 ? -20.414 -6.101  11.009 1.00 44.73  ? 174  GLU A C     1 ? 
ATOM   1333 O O     . GLU A 1 195 ? -21.069 -6.148  12.040 1.00 41.98  ? 174  GLU A O     1 ? 
ATOM   1334 C CB    . GLU A 1 195 ? -21.500 -5.068  9.025  1.00 58.15  ? 174  GLU A CB    1 ? 
ATOM   1335 C CG    . GLU A 1 195 ? -22.929 -5.130  9.560  1.00 68.02  ? 174  GLU A CG    1 ? 
ATOM   1336 C CD    . GLU A 1 195 ? -23.980 -5.153  8.463  1.00 77.37  ? 174  GLU A CD    1 ? 
ATOM   1337 O OE1   . GLU A 1 195 ? -24.891 -4.289  8.473  1.00 73.92  ? 174  GLU A OE1   1 ? 
ATOM   1338 O OE2   . GLU A 1 195 ? -23.858 -6.046  7.591  1.00 81.95  ? 174  GLU A OE2   1 ? 
ATOM   1339 N N     . ASN A 1 196 ? -19.657 -7.126  10.598 1.00 43.39  ? 175  ASN A N     1 ? 
ATOM   1340 C CA    . ASN A 1 196 ? -19.615 -8.356  11.375 1.00 42.21  ? 175  ASN A CA    1 ? 
ATOM   1341 C C     . ASN A 1 196 ? -18.289 -8.470  12.139 1.00 37.72  ? 175  ASN A C     1 ? 
ATOM   1342 O O     . ASN A 1 196 ? -17.286 -8.874  11.573 1.00 38.52  ? 175  ASN A O     1 ? 
ATOM   1343 C CB    . ASN A 1 196 ? -19.850 -9.584  10.505 1.00 40.30  ? 175  ASN A CB    1 ? 
ATOM   1344 C CG    . ASN A 1 196 ? -19.930 -10.852 11.329 1.00 40.88  ? 175  ASN A CG    1 ? 
ATOM   1345 O OD1   . ASN A 1 196 ? -19.962 -10.811 12.571 1.00 39.07  ? 175  ASN A OD1   1 ? 
ATOM   1346 N ND2   . ASN A 1 196 ? -19.981 -11.994 10.651 1.00 39.82  ? 175  ASN A ND2   1 ? 
ATOM   1347 N N     . PRO A 1 197 ? -18.256 -8.192  13.459 1.00 34.18  ? 176  PRO A N     1 ? 
ATOM   1348 C CA    . PRO A 1 197 ? -17.007 -8.268  14.227 1.00 33.63  ? 176  PRO A CA    1 ? 
ATOM   1349 C C     . PRO A 1 197 ? -16.446 -9.676  14.401 1.00 37.75  ? 176  PRO A C     1 ? 
ATOM   1350 O O     . PRO A 1 197 ? -15.263 -9.822  14.704 1.00 30.56  ? 176  PRO A O     1 ? 
ATOM   1351 C CB    . PRO A 1 197 ? -17.320 -7.613  15.588 1.00 34.60  ? 176  PRO A CB    1 ? 
ATOM   1352 C CG    . PRO A 1 197 ? -18.822 -7.479  15.649 1.00 35.79  ? 176  PRO A CG    1 ? 
ATOM   1353 C CD    . PRO A 1 197 ? -19.397 -7.735  14.263 1.00 35.01  ? 176  PRO A CD    1 ? 
ATOM   1354 N N     . TYR A 1 198 ? -17.292 -10.711 14.241 1.00 36.20  ? 177  TYR A N     1 ? 
ATOM   1355 C CA    . TYR A 1 198 ? -16.857 -12.077 14.493 1.00 35.61  ? 177  TYR A CA    1 ? 
ATOM   1356 C C     . TYR A 1 198 ? -16.318 -12.651 13.191 1.00 35.67  ? 177  TYR A C     1 ? 
ATOM   1357 O O     . TYR A 1 198 ? -16.896 -13.577 12.625 1.00 35.58  ? 177  TYR A O     1 ? 
ATOM   1358 C CB    . TYR A 1 198 ? -17.971 -12.913 15.125 1.00 33.58  ? 177  TYR A CB    1 ? 
ATOM   1359 C CG    . TYR A 1 198 ? -18.495 -12.256 16.380 1.00 35.22  ? 177  TYR A CG    1 ? 
ATOM   1360 C CD1   . TYR A 1 198 ? -17.839 -12.406 17.596 1.00 36.68  ? 177  TYR A CD1   1 ? 
ATOM   1361 C CD2   . TYR A 1 198 ? -19.608 -11.426 16.334 1.00 35.65  ? 177  TYR A CD2   1 ? 
ATOM   1362 C CE1   . TYR A 1 198 ? -18.303 -11.780 18.736 1.00 34.95  ? 177  TYR A CE1   1 ? 
ATOM   1363 C CE2   . TYR A 1 198 ? -20.075 -10.784 17.466 1.00 37.04  ? 177  TYR A CE2   1 ? 
ATOM   1364 C CZ    . TYR A 1 198 ? -19.420 -10.965 18.670 1.00 37.77  ? 177  TYR A CZ    1 ? 
ATOM   1365 O OH    . TYR A 1 198 ? -19.865 -10.311 19.777 1.00 36.79  ? 177  TYR A OH    1 ? 
ATOM   1366 N N     . SER A 1 199 ? -15.205 -12.067 12.733 1.00 35.11  ? 178  SER A N     1 ? 
ATOM   1367 C CA    . SER A 1 199 ? -14.615 -12.366 11.441 1.00 32.84  ? 178  SER A CA    1 ? 
ATOM   1368 C C     . SER A 1 199 ? -13.106 -12.510 11.577 1.00 31.26  ? 178  SER A C     1 ? 
ATOM   1369 O O     . SER A 1 199 ? -12.509 -12.019 12.533 1.00 28.18  ? 178  SER A O     1 ? 
ATOM   1370 C CB    . SER A 1 199 ? -14.940 -11.296 10.403 1.00 33.72  ? 178  SER A CB    1 ? 
ATOM   1371 O OG    . SER A 1 199 ? -16.328 -10.969 10.405 1.00 29.80  ? 178  SER A OG    1 ? 
ATOM   1372 N N     . ILE A 1 200 ? -12.519 -13.140 10.554 1.00 28.51  ? 179  ILE A N     1 ? 
ATOM   1373 C CA    . ILE A 1 200 ? -11.084 -13.234 10.370 1.00 30.17  ? 179  ILE A CA    1 ? 
ATOM   1374 C C     . ILE A 1 200 ? -10.732 -12.486 9.093  1.00 30.77  ? 179  ILE A C     1 ? 
ATOM   1375 O O     . ILE A 1 200 ? -11.449 -12.586 8.095  1.00 30.47  ? 179  ILE A O     1 ? 
ATOM   1376 C CB    . ILE A 1 200 ? -10.593 -14.696 10.335 1.00 29.59  ? 179  ILE A CB    1 ? 
ATOM   1377 C CG1   . ILE A 1 200 ? -9.076  -14.780 10.317 1.00 28.33  ? 179  ILE A CG1   1 ? 
ATOM   1378 C CG2   . ILE A 1 200 ? -11.190 -15.467 9.159  1.00 30.00  ? 179  ILE A CG2   1 ? 
ATOM   1379 C CD1   . ILE A 1 200 ? -8.531  -16.149 10.681 1.00 29.51  ? 179  ILE A CD1   1 ? 
ATOM   1380 N N     . ASP A 1 201 ? -9.635  -11.729 9.144  1.00 31.08  ? 180  ASP A N     1 ? 
ATOM   1381 C CA    . ASP A 1 201 ? -9.146  -11.034 7.967  1.00 31.72  ? 180  ASP A CA    1 ? 
ATOM   1382 C C     . ASP A 1 201 ? -7.629  -10.942 8.039  1.00 32.53  ? 180  ASP A C     1 ? 
ATOM   1383 O O     . ASP A 1 201 ? -7.012  -11.129 9.092  1.00 28.03  ? 180  ASP A O     1 ? 
ATOM   1384 C CB    . ASP A 1 201 ? -9.778  -9.657  7.814  1.00 33.12  ? 180  ASP A CB    1 ? 
ATOM   1385 C CG    . ASP A 1 201 ? -9.918  -9.161  6.377  1.00 37.50  ? 180  ASP A CG    1 ? 
ATOM   1386 O OD1   . ASP A 1 201 ? -9.485  -9.894  5.462  1.00 34.37  ? 180  ASP A OD1   1 ? 
ATOM   1387 O OD2   . ASP A 1 201 ? -10.469 -8.046  6.182  1.00 38.39  ? 180  ASP A OD2   1 ? 
ATOM   1388 N N     . ILE A 1 202 ? -7.049  -10.660 6.879  1.00 29.01  ? 181  ILE A N     1 ? 
ATOM   1389 C CA    . ILE A 1 202 ? -5.701  -10.150 6.782  1.00 29.50  ? 181  ILE A CA    1 ? 
ATOM   1390 C C     . ILE A 1 202 ? -5.641  -8.800  7.492  1.00 28.33  ? 181  ILE A C     1 ? 
ATOM   1391 O O     . ILE A 1 202 ? -6.483  -7.933  7.263  1.00 28.93  ? 181  ILE A O     1 ? 
ATOM   1392 C CB    . ILE A 1 202 ? -5.285  -10.045 5.311  1.00 33.67  ? 181  ILE A CB    1 ? 
ATOM   1393 C CG1   . ILE A 1 202 ? -5.366  -11.422 4.610  1.00 36.87  ? 181  ILE A CG1   1 ? 
ATOM   1394 C CG2   . ILE A 1 202 ? -3.883  -9.445  5.186  1.00 35.95  ? 181  ILE A CG2   1 ? 
ATOM   1395 C CD1   . ILE A 1 202 ? -5.111  -11.340 3.112  1.00 44.01  ? 181  ILE A CD1   1 ? 
ATOM   1396 N N     . MET A 1 203 ? -4.623  -8.611  8.342  1.00 24.31  ? 182  MET A N     1 ? 
ATOM   1397 C CA    . MET A 1 203 ? -4.534  -7.374  9.092  1.00 24.15  ? 182  MET A CA    1 ? 
ATOM   1398 C C     . MET A 1 203 ? -3.949  -6.296  8.192  1.00 21.69  ? 182  MET A C     1 ? 
ATOM   1399 O O     . MET A 1 203 ? -2.943  -6.512  7.537  1.00 23.49  ? 182  MET A O     1 ? 
ATOM   1400 C CB    . MET A 1 203 ? -3.674  -7.524  10.357 1.00 24.69  ? 182  MET A CB    1 ? 
ATOM   1401 C CG    . MET A 1 203 ? -4.227  -8.505  11.354 1.00 24.15  ? 182  MET A CG    1 ? 
ATOM   1402 S SD    . MET A 1 203 ? -3.304  -8.567  12.908 1.00 26.09  ? 182  MET A SD    1 ? 
ATOM   1403 C CE    . MET A 1 203 ? -1.895  -9.596  12.498 1.00 27.45  ? 182  MET A CE    1 ? 
ATOM   1404 N N     . GLN A 1 204 ? -4.557  -5.107  8.220  1.00 22.87  ? 183  GLN A N     1 ? 
ATOM   1405 C CA    . GLN A 1 204 ? -3.944  -3.928  7.620  1.00 22.80  ? 183  GLN A CA    1 ? 
ATOM   1406 C C     . GLN A 1 204 ? -2.961  -3.301  8.605  1.00 23.24  ? 183  GLN A C     1 ? 
ATOM   1407 O O     . GLN A 1 204 ? -3.125  -3.463  9.812  1.00 23.58  ? 183  GLN A O     1 ? 
ATOM   1408 C CB    . GLN A 1 204 ? -5.031  -2.931  7.212  1.00 22.97  ? 183  GLN A CB    1 ? 
ATOM   1409 C CG    . GLN A 1 204 ? -6.004  -3.503  6.183  1.00 24.55  ? 183  GLN A CG    1 ? 
ATOM   1410 C CD    . GLN A 1 204 ? -6.591  -2.437  5.283  1.00 24.42  ? 183  GLN A CD    1 ? 
ATOM   1411 O OE1   . GLN A 1 204 ? -7.197  -1.487  5.761  1.00 21.01  ? 183  GLN A OE1   1 ? 
ATOM   1412 N NE2   . GLN A 1 204 ? -6.424  -2.599  3.973  1.00 24.45  ? 183  GLN A NE2   1 ? 
ATOM   1413 N N     . LYS A 1 205 ? -1.994  -2.547  8.063  1.00 21.59  ? 184  LYS A N     1 ? 
ATOM   1414 C CA    . LYS A 1 205 ? -0.885  -1.994  8.819  1.00 22.48  ? 184  LYS A CA    1 ? 
ATOM   1415 C C     . LYS A 1 205 ? -0.541  -0.615  8.277  1.00 24.57  ? 184  LYS A C     1 ? 
ATOM   1416 O O     . LYS A 1 205 ? -0.897  -0.296  7.134  1.00 25.42  ? 184  LYS A O     1 ? 
ATOM   1417 C CB    . LYS A 1 205 ? 0.326   -2.925  8.682  1.00 23.76  ? 184  LYS A CB    1 ? 
ATOM   1418 C CG    . LYS A 1 205 ? 0.146   -4.296  9.342  1.00 24.29  ? 184  LYS A CG    1 ? 
ATOM   1419 C CD    . LYS A 1 205 ? 1.398   -5.152  9.467  1.00 23.29  ? 184  LYS A CD    1 ? 
ATOM   1420 C CE    . LYS A 1 205 ? 2.206   -5.233  8.224  1.00 23.04  ? 184  LYS A CE    1 ? 
ATOM   1421 N NZ    . LYS A 1 205 ? 3.159   -6.332  8.351  1.00 22.91  ? 184  LYS A NZ    1 ? 
ATOM   1422 N N     . ILE A 1 206 ? 0.174   0.171   9.098  1.00 22.53  ? 185  ILE A N     1 ? 
ATOM   1423 C CA    . ILE A 1 206 ? 0.587   1.533   8.794  1.00 23.57  ? 185  ILE A CA    1 ? 
ATOM   1424 C C     . ILE A 1 206 ? 1.847   1.518   7.929  1.00 24.47  ? 185  ILE A C     1 ? 
ATOM   1425 O O     . ILE A 1 206 ? 2.869   2.079   8.279  1.00 22.82  ? 185  ILE A O     1 ? 
ATOM   1426 C CB    . ILE A 1 206 ? 0.792   2.333   10.092 1.00 24.55  ? 185  ILE A CB    1 ? 
ATOM   1427 C CG1   . ILE A 1 206 ? 1.725   1.623   11.058 1.00 26.35  ? 185  ILE A CG1   1 ? 
ATOM   1428 C CG2   . ILE A 1 206 ? -0.558  2.625   10.744 1.00 23.64  ? 185  ILE A CG2   1 ? 
ATOM   1429 C CD1   . ILE A 1 206 ? 2.375   2.558   12.055 1.00 26.35  ? 185  ILE A CD1   1 ? 
ATOM   1430 N N     . TYR A 1 207 ? 1.748   0.874   6.765  1.00 26.91  ? 186  TYR A N     1 ? 
ATOM   1431 C CA    . TYR A 1 207 ? 2.842   0.818   5.816  1.00 24.68  ? 186  TYR A CA    1 ? 
ATOM   1432 C C     . TYR A 1 207 ? 2.331   1.337   4.467  1.00 28.06  ? 186  TYR A C     1 ? 
ATOM   1433 O O     . TYR A 1 207 ? 1.175   1.108   4.100  1.00 27.39  ? 186  TYR A O     1 ? 
ATOM   1434 C CB    . TYR A 1 207 ? 3.435   -0.588  5.678  1.00 24.47  ? 186  TYR A CB    1 ? 
ATOM   1435 C CG    . TYR A 1 207 ? 4.153   -1.028  6.946  1.00 25.12  ? 186  TYR A CG    1 ? 
ATOM   1436 C CD1   . TYR A 1 207 ? 3.431   -1.446  8.050  1.00 25.37  ? 186  TYR A CD1   1 ? 
ATOM   1437 C CD2   . TYR A 1 207 ? 5.534   -0.979  7.066  1.00 27.06  ? 186  TYR A CD2   1 ? 
ATOM   1438 C CE1   . TYR A 1 207 ? 4.055   -1.780  9.239  1.00 24.64  ? 186  TYR A CE1   1 ? 
ATOM   1439 C CE2   . TYR A 1 207 ? 6.177   -1.344  8.241  1.00 26.39  ? 186  TYR A CE2   1 ? 
ATOM   1440 C CZ    . TYR A 1 207 ? 5.429   -1.741  9.340  1.00 26.19  ? 186  TYR A CZ    1 ? 
ATOM   1441 O OH    . TYR A 1 207 ? 6.040   -2.108  10.512 1.00 24.66  ? 186  TYR A OH    1 ? 
ATOM   1442 N N     . GLU A 1 208 ? 3.220   2.087   3.810  1.00 31.03  ? 187  GLU A N     1 ? 
ATOM   1443 C CA    . GLU A 1 208 ? 3.031   2.557   2.445  1.00 37.54  ? 187  GLU A CA    1 ? 
ATOM   1444 C C     . GLU A 1 208 ? 4.239   2.110   1.638  1.00 34.20  ? 187  GLU A C     1 ? 
ATOM   1445 O O     . GLU A 1 208 ? 5.363   2.414   2.010  1.00 34.39  ? 187  GLU A O     1 ? 
ATOM   1446 C CB    . GLU A 1 208 ? 2.944   4.076   2.455  1.00 38.58  ? 187  GLU A CB    1 ? 
ATOM   1447 C CG    . GLU A 1 208 ? 2.728   4.690   1.075  1.00 46.45  ? 187  GLU A CG    1 ? 
ATOM   1448 C CD    . GLU A 1 208 ? 2.360   6.149   1.220  1.00 49.16  ? 187  GLU A CD    1 ? 
ATOM   1449 O OE1   . GLU A 1 208 ? 1.153   6.399   1.056  1.00 62.00  ? 187  GLU A OE1   1 ? 
ATOM   1450 O OE2   . GLU A 1 208 ? 3.231   7.001   1.529  1.00 45.31  ? 187  GLU A OE2   1 ? 
ATOM   1451 N N     . ASN A 1 209 ? 3.986   1.310   0.605  1.00 44.74  ? 188  ASN A N     1 ? 
ATOM   1452 C CA    . ASN A 1 209 ? 5.054   0.785   -0.227 1.00 42.31  ? 188  ASN A CA    1 ? 
ATOM   1453 C C     . ASN A 1 209 ? 6.079   0.080   0.663  1.00 39.50  ? 188  ASN A C     1 ? 
ATOM   1454 O O     . ASN A 1 209 ? 7.260   0.428   0.635  1.00 34.87  ? 188  ASN A O     1 ? 
ATOM   1455 C CB    . ASN A 1 209 ? 5.648   1.897   -1.084 1.00 42.32  ? 188  ASN A CB    1 ? 
ATOM   1456 C CG    . ASN A 1 209 ? 6.592   1.335   -2.124 1.00 44.94  ? 188  ASN A CG    1 ? 
ATOM   1457 O OD1   . ASN A 1 209 ? 7.624   1.943   -2.429 1.00 33.59  ? 188  ASN A OD1   1 ? 
ATOM   1458 N ND2   . ASN A 1 209 ? 6.255   0.174   -2.664 1.00 43.26  ? 188  ASN A ND2   1 ? 
ATOM   1459 N N     . ASN A 1 210 ? 5.573   -0.847  1.499  1.00 38.29  ? 189  ASN A N     1 ? 
ATOM   1460 C CA    . ASN A 1 210 ? 6.381   -1.695  2.375  1.00 40.16  ? 189  ASN A CA    1 ? 
ATOM   1461 C C     . ASN A 1 210 ? 7.317   -0.897  3.286  1.00 31.89  ? 189  ASN A C     1 ? 
ATOM   1462 O O     . ASN A 1 210 ? 8.369   -1.392  3.670  1.00 37.71  ? 189  ASN A O     1 ? 
ATOM   1463 C CB    . ASN A 1 210 ? 7.170   -2.728  1.574  1.00 50.46  ? 189  ASN A CB    1 ? 
ATOM   1464 C CG    . ASN A 1 210 ? 6.358   -3.963  1.253  1.00 54.92  ? 189  ASN A CG    1 ? 
ATOM   1465 O OD1   . ASN A 1 210 ? 5.349   -4.252  1.916  1.00 52.21  ? 189  ASN A OD1   1 ? 
ATOM   1466 N ND2   . ASN A 1 210 ? 6.790   -4.707  0.243  1.00 59.54  ? 189  ASN A ND2   1 ? 
ATOM   1467 N N     . THR A 1 211 ? 6.917   0.313   3.671  1.00 31.09  ? 190  THR A N     1 ? 
ATOM   1468 C CA    . THR A 1 211 ? 7.710   1.182   4.522  1.00 30.76  ? 190  THR A CA    1 ? 
ATOM   1469 C C     . THR A 1 211 ? 6.772   1.830   5.541  1.00 29.77  ? 190  THR A C     1 ? 
ATOM   1470 O O     . THR A 1 211 ? 5.742   2.386   5.168  1.00 26.62  ? 190  THR A O     1 ? 
ATOM   1471 C CB    . THR A 1 211 ? 8.400   2.298   3.729  1.00 32.23  ? 190  THR A CB    1 ? 
ATOM   1472 O OG1   . THR A 1 211 ? 9.035   1.770   2.572  1.00 38.02  ? 190  THR A OG1   1 ? 
ATOM   1473 C CG2   . THR A 1 211 ? 9.433   3.018   4.573  1.00 31.44  ? 190  THR A CG2   1 ? 
ATOM   1474 N N     . ARG A 1 212 ? 7.186   1.825   6.816  1.00 26.58  ? 191  ARG A N     1 ? 
ATOM   1475 C CA    . ARG A 1 212 ? 6.321   2.285   7.875  1.00 24.45  ? 191  ARG A CA    1 ? 
ATOM   1476 C C     . ARG A 1 212 ? 6.082   3.768   7.671  1.00 24.84  ? 191  ARG A C     1 ? 
ATOM   1477 O O     . ARG A 1 212 ? 7.005   4.535   7.407  1.00 26.91  ? 191  ARG A O     1 ? 
ATOM   1478 C CB    . ARG A 1 212 ? 6.919   2.038   9.264  1.00 24.39  ? 191  ARG A CB    1 ? 
ATOM   1479 C CG    . ARG A 1 212 ? 5.999   2.406   10.419 1.00 24.31  ? 191  ARG A CG    1 ? 
ATOM   1480 C CD    . ARG A 1 212 ? 6.756   2.624   11.713 1.00 22.21  ? 191  ARG A CD    1 ? 
ATOM   1481 N NE    . ARG A 1 212 ? 7.488   1.417   12.097 1.00 22.41  ? 191  ARG A NE    1 ? 
ATOM   1482 C CZ    . ARG A 1 212 ? 6.986   0.365   12.732 1.00 24.37  ? 191  ARG A CZ    1 ? 
ATOM   1483 N NH1   . ARG A 1 212 ? 5.714   0.375   13.143 1.00 22.14  ? 191  ARG A NH1   1 ? 
ATOM   1484 N NH2   . ARG A 1 212 ? 7.782   -0.677  13.000 1.00 21.96  ? 191  ARG A NH2   1 ? 
ATOM   1485 N N     . ARG A 1 213 ? 4.822   4.161   7.775  1.00 26.84  ? 192  ARG A N     1 ? 
ATOM   1486 C CA    . ARG A 1 213 ? 4.465   5.565   7.841  1.00 29.18  ? 192  ARG A CA    1 ? 
ATOM   1487 C C     . ARG A 1 213 ? 3.557   5.755   9.042  1.00 26.35  ? 192  ARG A C     1 ? 
ATOM   1488 O O     . ARG A 1 213 ? 2.400   5.327   9.024  1.00 23.12  ? 192  ARG A O     1 ? 
ATOM   1489 C CB    . ARG A 1 213 ? 3.664   5.954   6.604  1.00 31.29  ? 192  ARG A CB    1 ? 
ATOM   1490 C CG    . ARG A 1 213 ? 4.485   6.242   5.363  1.00 42.48  ? 192  ARG A CG    1 ? 
ATOM   1491 C CD    . ARG A 1 213 ? 4.537   7.746   5.150  1.00 44.12  ? 192  ARG A CD    1 ? 
ATOM   1492 N NE    . ARG A 1 213 ? 3.210   8.333   4.929  1.00 43.86  ? 192  ARG A NE    1 ? 
ATOM   1493 C CZ    . ARG A 1 213 ? 2.986   9.628   4.817  1.00 44.37  ? 192  ARG A CZ    1 ? 
ATOM   1494 N NH1   . ARG A 1 213 ? 4.000   10.462  4.871  1.00 50.69  ? 192  ARG A NH1   1 ? 
ATOM   1495 N NH2   . ARG A 1 213 ? 1.762   10.085  4.679  1.00 47.73  ? 192  ARG A NH2   1 ? 
ATOM   1496 N N     . THR A 1 214 ? 4.118   6.406   10.048 1.00 25.63  ? 193  THR A N     1 ? 
ATOM   1497 C CA    . THR A 1 214 ? 3.491   6.506   11.347 1.00 24.18  ? 193  THR A CA    1 ? 
ATOM   1498 C C     . THR A 1 214 ? 2.441   7.590   11.252 1.00 23.95  ? 193  THR A C     1 ? 
ATOM   1499 O O     . THR A 1 214 ? 2.499   8.431   10.337 1.00 21.50  ? 193  THR A O     1 ? 
ATOM   1500 C CB    . THR A 1 214 ? 4.495   6.858   12.442 1.00 22.64  ? 193  THR A CB    1 ? 
ATOM   1501 O OG1   . THR A 1 214 ? 5.040   8.129   12.124 1.00 23.48  ? 193  THR A OG1   1 ? 
ATOM   1502 C CG2   . THR A 1 214 ? 5.640   5.876   12.613 1.00 22.49  ? 193  THR A CG2   1 ? 
ATOM   1503 N N     . PRO A 1 215 ? 1.510   7.658   12.229 1.00 19.55  ? 194  PRO A N     1 ? 
ATOM   1504 C CA    . PRO A 1 215 ? 0.711   8.861   12.396 1.00 21.44  ? 194  PRO A CA    1 ? 
ATOM   1505 C C     . PRO A 1 215 ? 1.540   10.145  12.438 1.00 23.09  ? 194  PRO A C     1 ? 
ATOM   1506 O O     . PRO A 1 215 ? 1.179   11.121  11.778 1.00 25.91  ? 194  PRO A O     1 ? 
ATOM   1507 C CB    . PRO A 1 215 ? -0.071  8.530   13.713 1.00 21.42  ? 194  PRO A CB    1 ? 
ATOM   1508 C CG    . PRO A 1 215 ? -0.241  7.029   13.617 1.00 20.86  ? 194  PRO A CG    1 ? 
ATOM   1509 C CD    . PRO A 1 215 ? 1.104   6.558   13.120 1.00 20.90  ? 194  PRO A CD    1 ? 
ATOM   1510 N N     . ALA A 1 216 ? 2.669   10.147  13.151 1.00 19.19  ? 195  ALA A N     1 ? 
ATOM   1511 C CA    . ALA A 1 216 ? 3.519   11.337  13.185 1.00 23.06  ? 195  ALA A CA    1 ? 
ATOM   1512 C C     . ALA A 1 216 ? 4.034   11.726  11.788 1.00 26.65  ? 195  ALA A C     1 ? 
ATOM   1513 O O     . ALA A 1 216 ? 4.049   12.897  11.436 1.00 27.46  ? 195  ALA A O     1 ? 
ATOM   1514 C CB    . ALA A 1 216 ? 4.652   11.162  14.168 1.00 22.56  ? 195  ALA A CB    1 ? 
ATOM   1515 N N     . ASP A 1 217 ? 4.473   10.753  10.993 1.00 25.80  ? 196  ASP A N     1 ? 
ATOM   1516 C CA    . ASP A 1 217 ? 4.883   11.032  9.623  1.00 29.46  ? 196  ASP A CA    1 ? 
ATOM   1517 C C     . ASP A 1 217 ? 3.737   11.669  8.852  1.00 28.91  ? 196  ASP A C     1 ? 
ATOM   1518 O O     . ASP A 1 217 ? 3.953   12.568  8.043  1.00 30.08  ? 196  ASP A O     1 ? 
ATOM   1519 C CB    . ASP A 1 217 ? 5.319   9.788   8.876  1.00 27.39  ? 196  ASP A CB    1 ? 
ATOM   1520 C CG    . ASP A 1 217 ? 6.571   9.089   9.381  1.00 27.45  ? 196  ASP A CG    1 ? 
ATOM   1521 O OD1   . ASP A 1 217 ? 7.578   9.774   9.686  1.00 27.87  ? 196  ASP A OD1   1 ? 
ATOM   1522 O OD2   . ASP A 1 217 ? 6.551   7.853   9.373  1.00 26.40  ? 196  ASP A OD2   1 ? 
ATOM   1523 N N     . SER A 1 218 ? 2.520   11.194  9.131  1.00 29.14  ? 197  SER A N     1 ? 
ATOM   1524 C CA    . SER A 1 218 ? 1.335   11.493  8.345  1.00 30.70  ? 197  SER A CA    1 ? 
ATOM   1525 C C     . SER A 1 218 ? 0.748   12.841  8.742  1.00 27.42  ? 197  SER A C     1 ? 
ATOM   1526 O O     . SER A 1 218 ? 0.171   13.513  7.896  1.00 26.07  ? 197  SER A O     1 ? 
ATOM   1527 C CB    . SER A 1 218 ? 0.276   10.385  8.520  1.00 33.65  ? 197  SER A CB    1 ? 
ATOM   1528 O OG    . SER A 1 218 ? 0.766   9.096   8.148  1.00 37.03  ? 197  SER A OG    1 ? 
ATOM   1529 N N     . TYR A 1 219 ? 0.879   13.222  10.026 1.00 26.14  ? 198  TYR A N     1 ? 
ATOM   1530 C CA    . TYR A 1 219 ? 0.320   14.460  10.539 1.00 24.37  ? 198  TYR A CA    1 ? 
ATOM   1531 C C     . TYR A 1 219 ? 1.355   15.588  10.630 1.00 24.62  ? 198  TYR A C     1 ? 
ATOM   1532 O O     . TYR A 1 219 ? 0.968   16.760  10.647 1.00 24.12  ? 198  TYR A O     1 ? 
ATOM   1533 C CB    . TYR A 1 219 ? -0.319  14.267  11.918 1.00 25.13  ? 198  TYR A CB    1 ? 
ATOM   1534 C CG    . TYR A 1 219 ? -1.671  13.564  11.941 1.00 23.10  ? 198  TYR A CG    1 ? 
ATOM   1535 C CD1   . TYR A 1 219 ? -1.742  12.177  11.939 1.00 23.76  ? 198  TYR A CD1   1 ? 
ATOM   1536 C CD2   . TYR A 1 219 ? -2.871  14.275  11.976 1.00 23.23  ? 198  TYR A CD2   1 ? 
ATOM   1537 C CE1   . TYR A 1 219 ? -2.958  11.512  11.957 1.00 24.30  ? 198  TYR A CE1   1 ? 
ATOM   1538 C CE2   . TYR A 1 219 ? -4.092  13.628  11.991 1.00 25.42  ? 198  TYR A CE2   1 ? 
ATOM   1539 C CZ    . TYR A 1 219 ? -4.138  12.233  11.979 1.00 25.71  ? 198  TYR A CZ    1 ? 
ATOM   1540 O OH    . TYR A 1 219 ? -5.318  11.524  12.000 1.00 25.61  ? 198  TYR A OH    1 ? 
ATOM   1541 N N     . LEU A 1 220 ? 2.636   15.250  10.769 1.00 23.42  ? 199  LEU A N     1 ? 
ATOM   1542 C CA    . LEU A 1 220 ? 3.693   16.251  10.859 1.00 27.96  ? 199  LEU A CA    1 ? 
ATOM   1543 C C     . LEU A 1 220 ? 4.524   16.197  9.574  1.00 26.46  ? 199  LEU A C     1 ? 
ATOM   1544 O O     . LEU A 1 220 ? 5.701   15.867  9.602  1.00 28.55  ? 199  LEU A O     1 ? 
ATOM   1545 C CB    . LEU A 1 220 ? 4.570   16.040  12.099 1.00 25.57  ? 199  LEU A CB    1 ? 
ATOM   1546 C CG    . LEU A 1 220 ? 3.850   16.064  13.450 1.00 24.86  ? 199  LEU A CG    1 ? 
ATOM   1547 C CD1   . LEU A 1 220 ? 4.866   15.749  14.547 1.00 27.15  ? 199  LEU A CD1   1 ? 
ATOM   1548 C CD2   . LEU A 1 220 ? 3.133   17.392  13.690 1.00 24.60  ? 199  LEU A CD2   1 ? 
ATOM   1549 N N     . THR A 1 221 ? 3.865   16.471  8.443  1.00 29.55  ? 200  THR A N     1 ? 
ATOM   1550 C CA    . THR A 1 221 ? 4.503   16.471  7.135  1.00 32.33  ? 200  THR A CA    1 ? 
ATOM   1551 C C     . THR A 1 221 ? 5.372   17.721  6.988  1.00 31.66  ? 200  THR A C     1 ? 
ATOM   1552 O O     . THR A 1 221 ? 5.344   18.612  7.820  1.00 27.53  ? 200  THR A O     1 ? 
ATOM   1553 C CB    . THR A 1 221 ? 3.434   16.450  6.047  1.00 33.56  ? 200  THR A CB    1 ? 
ATOM   1554 O OG1   . THR A 1 221 ? 2.606   17.557  6.363  1.00 32.47  ? 200  THR A OG1   1 ? 
ATOM   1555 C CG2   . THR A 1 221 ? 2.604   15.181  6.026  1.00 37.12  ? 200  THR A CG2   1 ? 
ATOM   1556 N N     . GLU A 1 222 ? 6.125   17.784  5.883  1.00 34.35  ? 201  GLU A N     1 ? 
ATOM   1557 C CA    . GLU A 1 222 ? 6.908   18.967  5.537  1.00 36.39  ? 201  GLU A CA    1 ? 
ATOM   1558 C C     . GLU A 1 222 ? 6.050   20.229  5.643  1.00 30.15  ? 201  GLU A C     1 ? 
ATOM   1559 O O     . GLU A 1 222 ? 6.441   21.223  6.253  1.00 37.28  ? 201  GLU A O     1 ? 
ATOM   1560 C CB    . GLU A 1 222 ? 7.469   18.714  4.129  1.00 41.87  ? 201  GLU A CB    1 ? 
ATOM   1561 C CG    . GLU A 1 222 ? 8.312   19.846  3.548  1.00 46.47  ? 201  GLU A CG    1 ? 
ATOM   1562 C CD    . GLU A 1 222 ? 8.542   19.711  2.053  1.00 44.88  ? 201  GLU A CD    1 ? 
ATOM   1563 O OE1   . GLU A 1 222 ? 8.874   20.749  1.440  1.00 53.11  ? 201  GLU A OE1   1 ? 
ATOM   1564 O OE2   . GLU A 1 222 ? 8.356   18.602  1.493  1.00 43.81  ? 201  GLU A OE2   1 ? 
ATOM   1565 N N     . ASP A 1 223 ? 4.848   20.175  5.073  1.00 37.00  ? 202  ASP A N     1 ? 
ATOM   1566 C CA    . ASP A 1 223 ? 3.963   21.326  5.066  1.00 40.62  ? 202  ASP A CA    1 ? 
ATOM   1567 C C     . ASP A 1 223 ? 3.629   21.769  6.483  1.00 38.61  ? 202  ASP A C     1 ? 
ATOM   1568 O O     . ASP A 1 223 ? 3.583   22.964  6.771  1.00 39.67  ? 202  ASP A O     1 ? 
ATOM   1569 C CB    . ASP A 1 223 ? 2.676   21.033  4.309  1.00 50.17  ? 202  ASP A CB    1 ? 
ATOM   1570 C CG    . ASP A 1 223 ? 2.543   21.760  2.981  1.00 55.90  ? 202  ASP A CG    1 ? 
ATOM   1571 O OD1   . ASP A 1 223 ? 3.578   22.237  2.486  1.00 54.23  ? 202  ASP A OD1   1 ? 
ATOM   1572 O OD2   . ASP A 1 223 ? 1.399   21.901  2.500  1.00 70.51  ? 202  ASP A OD2   1 ? 
ATOM   1573 N N     . VAL A 1 224 ? 3.338   20.797  7.356  1.00 32.28  ? 203  VAL A N     1 ? 
ATOM   1574 C CA    . VAL A 1 224 ? 2.849   21.128  8.679  1.00 27.52  ? 203  VAL A CA    1 ? 
ATOM   1575 C C     . VAL A 1 224 ? 4.008   21.729  9.461  1.00 25.68  ? 203  VAL A C     1 ? 
ATOM   1576 O O     . VAL A 1 224 ? 3.845   22.713  10.187 1.00 25.79  ? 203  VAL A O     1 ? 
ATOM   1577 C CB    . VAL A 1 224 ? 2.266   19.871  9.362  1.00 30.29  ? 203  VAL A CB    1 ? 
ATOM   1578 C CG1   . VAL A 1 224 ? 2.024   20.089  10.844 1.00 30.10  ? 203  VAL A CG1   1 ? 
ATOM   1579 C CG2   . VAL A 1 224 ? 0.995   19.400  8.658  1.00 28.63  ? 203  VAL A CG2   1 ? 
ATOM   1580 N N     . ARG A 1 225 ? 5.185   21.111  9.304  1.00 27.86  ? 204  ARG A N     1 ? 
ATOM   1581 C CA    . ARG A 1 225 ? 6.362   21.513  10.056 1.00 30.16  ? 204  ARG A CA    1 ? 
ATOM   1582 C C     . ARG A 1 225 ? 6.830   22.908  9.634  1.00 34.72  ? 204  ARG A C     1 ? 
ATOM   1583 O O     . ARG A 1 225 ? 7.513   23.571  10.411 1.00 33.96  ? 204  ARG A O     1 ? 
ATOM   1584 C CB    . ARG A 1 225 ? 7.465   20.488  9.800  1.00 31.08  ? 204  ARG A CB    1 ? 
ATOM   1585 C CG    . ARG A 1 225 ? 7.222   19.185  10.552 1.00 31.56  ? 204  ARG A CG    1 ? 
ATOM   1586 C CD    . ARG A 1 225 ? 8.217   18.120  10.139 1.00 32.04  ? 204  ARG A CD    1 ? 
ATOM   1587 N NE    . ARG A 1 225 ? 8.125   16.894  10.945 1.00 35.01  ? 204  ARG A NE    1 ? 
ATOM   1588 C CZ    . ARG A 1 225 ? 8.923   16.551  11.970 1.00 30.33  ? 204  ARG A CZ    1 ? 
ATOM   1589 N NH1   . ARG A 1 225 ? 9.849   17.363  12.452 1.00 28.32  ? 204  ARG A NH1   1 ? 
ATOM   1590 N NH2   . ARG A 1 225 ? 8.733   15.398  12.583 1.00 29.25  ? 204  ARG A NH2   1 ? 
ATOM   1591 N N     . ALA A 1 226 ? 6.489   23.311  8.399  1.00 37.10  ? 205  ALA A N     1 ? 
ATOM   1592 C CA    . ALA A 1 226 ? 6.873   24.612  7.856  1.00 41.89  ? 205  ALA A CA    1 ? 
ATOM   1593 C C     . ALA A 1 226 ? 6.014   25.727  8.455  1.00 40.37  ? 205  ALA A C     1 ? 
ATOM   1594 O O     . ALA A 1 226 ? 6.362   26.894  8.356  1.00 41.94  ? 205  ALA A O     1 ? 
ATOM   1595 C CB    . ALA A 1 226 ? 6.792   24.586  6.341  1.00 39.59  ? 205  ALA A CB    1 ? 
ATOM   1596 N N     . ARG A 1 227 ? 4.910   25.376  9.121  1.00 39.89  ? 206  ARG A N     1 ? 
ATOM   1597 C CA    . ARG A 1 227 ? 4.071   26.377  9.763  1.00 37.16  ? 206  ARG A CA    1 ? 
ATOM   1598 C C     . ARG A 1 227 ? 4.858   27.131  10.825 1.00 40.20  ? 206  ARG A C     1 ? 
ATOM   1599 O O     . ARG A 1 227 ? 5.543   26.527  11.643 1.00 41.45  ? 206  ARG A O     1 ? 
ATOM   1600 C CB    . ARG A 1 227 ? 2.861   25.738  10.456 1.00 37.98  ? 206  ARG A CB    1 ? 
ATOM   1601 C CG    . ARG A 1 227 ? 1.855   25.149  9.481  1.00 34.94  ? 206  ARG A CG    1 ? 
ATOM   1602 C CD    . ARG A 1 227 ? 0.842   24.313  10.225 1.00 33.15  ? 206  ARG A CD    1 ? 
ATOM   1603 N NE    . ARG A 1 227 ? -0.005  23.540  9.318  1.00 30.10  ? 206  ARG A NE    1 ? 
ATOM   1604 C CZ    . ARG A 1 227 ? -0.956  22.713  9.729  1.00 32.67  ? 206  ARG A CZ    1 ? 
ATOM   1605 N NH1   . ARG A 1 227 ? -1.077  22.433  11.017 1.00 29.91  ? 206  ARG A NH1   1 ? 
ATOM   1606 N NH2   . ARG A 1 227 ? -1.764  22.152  8.856  1.00 31.95  ? 206  ARG A NH2   1 ? 
ATOM   1607 N N     . GLU A 1 228 ? 4.726   28.464  10.818 1.00 38.55  ? 207  GLU A N     1 ? 
ATOM   1608 C CA    . GLU A 1 228 ? 5.487   29.310  11.722 1.00 37.87  ? 207  GLU A CA    1 ? 
ATOM   1609 C C     . GLU A 1 228 ? 4.991   29.150  13.153 1.00 31.77  ? 207  GLU A C     1 ? 
ATOM   1610 O O     . GLU A 1 228 ? 5.719   29.469  14.085 1.00 32.35  ? 207  GLU A O     1 ? 
ATOM   1611 C CB    . GLU A 1 228 ? 5.471   30.785  11.301 1.00 39.65  ? 207  GLU A CB    1 ? 
ATOM   1612 C CG    . GLU A 1 228 ? 6.425   31.020  10.129 1.00 48.18  ? 207  GLU A CG    1 ? 
ATOM   1613 C CD    . GLU A 1 228 ? 6.293   32.273  9.270  1.00 58.30  ? 207  GLU A CD    1 ? 
ATOM   1614 O OE1   . GLU A 1 228 ? 6.876   32.201  8.170  1.00 59.13  ? 207  GLU A OE1   1 ? 
ATOM   1615 O OE2   . GLU A 1 228 ? 5.664   33.288  9.649  1.00 65.86  ? 207  GLU A OE2   1 ? 
ATOM   1616 N N     . ASN A 1 229 ? 3.757   28.690  13.319 1.00 34.04  ? 208  ASN A N     1 ? 
ATOM   1617 C CA    . ASN A 1 229 ? 3.135   28.625  14.637 1.00 37.87  ? 208  ASN A CA    1 ? 
ATOM   1618 C C     . ASN A 1 229 ? 3.304   27.237  15.287 1.00 32.37  ? 208  ASN A C     1 ? 
ATOM   1619 O O     . ASN A 1 229 ? 2.675   26.956  16.306 1.00 38.07  ? 208  ASN A O     1 ? 
ATOM   1620 C CB    . ASN A 1 229 ? 1.684   29.097  14.553 1.00 33.47  ? 208  ASN A CB    1 ? 
ATOM   1621 C CG    . ASN A 1 229 ? 0.829   28.295  13.596 1.00 35.95  ? 208  ASN A CG    1 ? 
ATOM   1622 O OD1   . ASN A 1 229 ? 1.264   27.942  12.492 1.00 39.15  ? 208  ASN A OD1   1 ? 
ATOM   1623 N ND2   . ASN A 1 229 ? -0.402  27.994  13.989 1.00 39.39  ? 208  ASN A ND2   1 ? 
ATOM   1624 N N     . LEU A 1 230 ? 4.158   26.389  14.711 1.00 31.58  ? 209  LEU A N     1 ? 
ATOM   1625 C CA    . LEU A 1 230 ? 4.487   25.085  15.277 1.00 31.91  ? 209  LEU A CA    1 ? 
ATOM   1626 C C     . LEU A 1 230 ? 5.994   25.024  15.499 1.00 32.74  ? 209  LEU A C     1 ? 
ATOM   1627 O O     . LEU A 1 230 ? 6.763   25.261  14.571 1.00 34.88  ? 209  LEU A O     1 ? 
ATOM   1628 C CB    . LEU A 1 230 ? 4.024   23.980  14.327 1.00 29.22  ? 209  LEU A CB    1 ? 
ATOM   1629 C CG    . LEU A 1 230 ? 4.411   22.545  14.717 1.00 30.96  ? 209  LEU A CG    1 ? 
ATOM   1630 C CD1   . LEU A 1 230 ? 3.897   22.169  16.098 1.00 31.06  ? 209  LEU A CD1   1 ? 
ATOM   1631 C CD2   . LEU A 1 230 ? 3.895   21.522  13.714 1.00 31.75  ? 209  LEU A CD2   1 ? 
ATOM   1632 N N     . THR A 1 231 ? 6.400   24.757  16.745 1.00 32.07  ? 210  THR A N     1 ? 
ATOM   1633 C CA    . THR A 1 231 ? 7.787   24.467  17.076 1.00 31.79  ? 210  THR A CA    1 ? 
ATOM   1634 C C     . THR A 1 231 ? 7.877   23.043  17.610 1.00 27.65  ? 210  THR A C     1 ? 
ATOM   1635 O O     . THR A 1 231 ? 7.179   22.706  18.551 1.00 27.98  ? 210  THR A O     1 ? 
ATOM   1636 C CB    . THR A 1 231 ? 8.298   25.470  18.106 1.00 31.51  ? 210  THR A CB    1 ? 
ATOM   1637 O OG1   . THR A 1 231 ? 8.117   26.738  17.477 1.00 32.39  ? 210  THR A OG1   1 ? 
ATOM   1638 C CG2   . THR A 1 231 ? 9.758   25.262  18.445 1.00 31.59  ? 210  THR A CG2   1 ? 
ATOM   1639 N N     . ILE A 1 232 ? 8.755   22.242  17.027 1.00 28.32  ? 211  ILE A N     1 ? 
ATOM   1640 C CA    . ILE A 1 232 ? 9.044   20.897  17.497 1.00 28.40  ? 211  ILE A CA    1 ? 
ATOM   1641 C C     . ILE A 1 232 ? 10.463  20.898  18.034 1.00 27.10  ? 211  ILE A C     1 ? 
ATOM   1642 O O     . ILE A 1 232 ? 11.355  21.278  17.299 1.00 28.62  ? 211  ILE A O     1 ? 
ATOM   1643 C CB    . ILE A 1 232 ? 8.909   19.888  16.354 1.00 26.61  ? 211  ILE A CB    1 ? 
ATOM   1644 C CG1   . ILE A 1 232 ? 7.517   19.925  15.749 1.00 26.66  ? 211  ILE A CG1   1 ? 
ATOM   1645 C CG2   . ILE A 1 232 ? 9.306   18.479  16.819 1.00 27.78  ? 211  ILE A CG2   1 ? 
ATOM   1646 C CD1   . ILE A 1 232 ? 7.327   19.004  14.561 1.00 27.35  ? 211  ILE A CD1   1 ? 
ATOM   1647 N N     . ILE A 1 233 ? 10.663  20.507  19.300 1.00 24.23  ? 212  ILE A N     1 ? 
ATOM   1648 C CA    . ILE A 1 233 ? 11.998  20.264  19.818 1.00 23.33  ? 212  ILE A CA    1 ? 
ATOM   1649 C C     . ILE A 1 233 ? 12.139  18.777  20.181 1.00 26.98  ? 212  ILE A C     1 ? 
ATOM   1650 O O     . ILE A 1 233 ? 11.394  18.263  21.028 1.00 26.17  ? 212  ILE A O     1 ? 
ATOM   1651 C CB    . ILE A 1 233 ? 12.320  21.165  21.017 1.00 24.17  ? 212  ILE A CB    1 ? 
ATOM   1652 C CG1   . ILE A 1 233 ? 12.019  22.643  20.751 1.00 29.22  ? 212  ILE A CG1   1 ? 
ATOM   1653 C CG2   . ILE A 1 233 ? 13.773  20.994  21.449 1.00 24.29  ? 212  ILE A CG2   1 ? 
ATOM   1654 C CD1   . ILE A 1 233 ? 12.190  23.531  21.968 1.00 31.14  ? 212  ILE A CD1   1 ? 
ATOM   1655 N N     . THR A 1 234 ? 13.111  18.090  19.559 1.00 25.33  ? 213  THR A N     1 ? 
ATOM   1656 C CA    . THR A 1 234 ? 13.496  16.733  19.959 1.00 25.34  ? 213  THR A CA    1 ? 
ATOM   1657 C C     . THR A 1 234 ? 14.656  16.781  20.949 1.00 26.05  ? 213  THR A C     1 ? 
ATOM   1658 O O     . THR A 1 234 ? 15.240  17.827  21.233 1.00 24.55  ? 213  THR A O     1 ? 
ATOM   1659 C CB    . THR A 1 234 ? 13.852  15.885  18.734 1.00 27.08  ? 213  THR A CB    1 ? 
ATOM   1660 O OG1   . THR A 1 234 ? 14.728  16.666  17.937 1.00 30.02  ? 213  THR A OG1   1 ? 
ATOM   1661 C CG2   . THR A 1 234 ? 12.665  15.530  17.865 1.00 28.04  ? 213  THR A CG2   1 ? 
ATOM   1662 N N     . HIS A 1 235 ? 14.989  15.617  21.514 1.00 26.27  ? 214  HIS A N     1 ? 
ATOM   1663 C CA    . HIS A 1 235 ? 15.922  15.524  22.628 1.00 23.22  ? 214  HIS A CA    1 ? 
ATOM   1664 C C     . HIS A 1 235 ? 15.568  16.527  23.719 1.00 25.21  ? 214  HIS A C     1 ? 
ATOM   1665 O O     . HIS A 1 235 ? 16.459  17.199  24.290 1.00 23.95  ? 214  HIS A O     1 ? 
ATOM   1666 C CB    . HIS A 1 235 ? 17.366  15.644  22.126 1.00 26.31  ? 214  HIS A CB    1 ? 
ATOM   1667 C CG    . HIS A 1 235 ? 17.734  14.608  21.126 1.00 21.61  ? 214  HIS A CG    1 ? 
ATOM   1668 N ND1   . HIS A 1 235 ? 18.155  13.348  21.498 1.00 21.57  ? 214  HIS A ND1   1 ? 
ATOM   1669 C CD2   . HIS A 1 235 ? 17.748  14.624  19.782 1.00 24.72  ? 214  HIS A CD2   1 ? 
ATOM   1670 C CE1   . HIS A 1 235 ? 18.405  12.631  20.402 1.00 22.32  ? 214  HIS A CE1   1 ? 
ATOM   1671 N NE2   . HIS A 1 235 ? 18.137  13.369  19.347 1.00 23.02  ? 214  HIS A NE2   1 ? 
ATOM   1672 N N     . ALA A 1 236 ? 14.255  16.603  24.014 1.00 22.96  ? 215  ALA A N     1 ? 
ATOM   1673 C CA    . ALA A 1 236 ? 13.716  17.450  25.068 1.00 20.70  ? 215  ALA A CA    1 ? 
ATOM   1674 C C     . ALA A 1 236 ? 12.959  16.585  26.072 1.00 21.26  ? 215  ALA A C     1 ? 
ATOM   1675 O O     . ALA A 1 236 ? 11.856  16.112  25.781 1.00 23.39  ? 215  ALA A O     1 ? 
ATOM   1676 C CB    . ALA A 1 236 ? 12.827  18.492  24.481 1.00 20.23  ? 215  ALA A CB    1 ? 
ATOM   1677 N N     . PHE A 1 237 ? 13.578  16.384  27.239 1.00 20.75  ? 216  PHE A N     1 ? 
ATOM   1678 C CA    . PHE A 1 237 ? 13.068  15.460  28.228 1.00 21.83  ? 216  PHE A CA    1 ? 
ATOM   1679 C C     . PHE A 1 237 ? 12.362  16.265  29.308 1.00 22.22  ? 216  PHE A C     1 ? 
ATOM   1680 O O     . PHE A 1 237 ? 13.012  17.028  30.032 1.00 21.37  ? 216  PHE A O     1 ? 
ATOM   1681 C CB    . PHE A 1 237 ? 14.207  14.646  28.830 1.00 19.41  ? 216  PHE A CB    1 ? 
ATOM   1682 C CG    . PHE A 1 237 ? 13.759  13.732  29.957 1.00 20.71  ? 216  PHE A CG    1 ? 
ATOM   1683 C CD1   . PHE A 1 237 ? 12.941  12.653  29.682 1.00 20.54  ? 216  PHE A CD1   1 ? 
ATOM   1684 C CD2   . PHE A 1 237 ? 14.137  13.953  31.278 1.00 20.43  ? 216  PHE A CD2   1 ? 
ATOM   1685 C CE1   . PHE A 1 237 ? 12.539  11.801  30.694 1.00 21.88  ? 216  PHE A CE1   1 ? 
ATOM   1686 C CE2   . PHE A 1 237 ? 13.734  13.115  32.289 1.00 22.48  ? 216  PHE A CE2   1 ? 
ATOM   1687 C CZ    . PHE A 1 237 ? 12.932  12.025  31.995 1.00 24.53  ? 216  PHE A CZ    1 ? 
ATOM   1688 N N     . VAL A 1 238 ? 11.034  16.133  29.366 1.00 20.11  ? 217  VAL A N     1 ? 
ATOM   1689 C CA    . VAL A 1 238 ? 10.260  16.888  30.334 1.00 19.86  ? 217  VAL A CA    1 ? 
ATOM   1690 C C     . VAL A 1 238 ? 10.382  16.212  31.692 1.00 22.69  ? 217  VAL A C     1 ? 
ATOM   1691 O O     . VAL A 1 238 ? 10.224  14.997  31.817 1.00 22.61  ? 217  VAL A O     1 ? 
ATOM   1692 C CB    . VAL A 1 238 ? 8.809   17.068  29.887 1.00 20.15  ? 217  VAL A CB    1 ? 
ATOM   1693 C CG1   . VAL A 1 238 ? 7.922   17.657  30.987 1.00 20.27  ? 217  VAL A CG1   1 ? 
ATOM   1694 C CG2   . VAL A 1 238 ? 8.735   17.876  28.602 1.00 22.17  ? 217  VAL A CG2   1 ? 
ATOM   1695 N N     . ARG A 1 239 ? 10.660  17.025  32.716 1.00 18.94  ? 218  ARG A N     1 ? 
ATOM   1696 C CA    . ARG A 1 239 ? 10.871  16.520  34.059 1.00 19.81  ? 218  ARG A CA    1 ? 
ATOM   1697 C C     . ARG A 1 239 ? 9.671   16.760  34.964 1.00 22.09  ? 218  ARG A C     1 ? 
ATOM   1698 O O     . ARG A 1 239 ? 9.506   16.052  35.942 1.00 21.29  ? 218  ARG A O     1 ? 
ATOM   1699 C CB    . ARG A 1 239 ? 12.148  17.146  34.640 1.00 22.03  ? 218  ARG A CB    1 ? 
ATOM   1700 C CG    . ARG A 1 239 ? 13.367  16.688  33.843 1.00 23.36  ? 218  ARG A CG    1 ? 
ATOM   1701 C CD    . ARG A 1 239 ? 14.636  17.487  33.905 1.00 24.86  ? 218  ARG A CD    1 ? 
ATOM   1702 N NE    . ARG A 1 239 ? 14.852  18.240  35.130 1.00 24.82  ? 218  ARG A NE    1 ? 
ATOM   1703 C CZ    . ARG A 1 239 ? 15.962  18.274  35.836 1.00 26.04  ? 218  ARG A CZ    1 ? 
ATOM   1704 N NH1   . ARG A 1 239 ? 16.997  17.511  35.549 1.00 24.20  ? 218  ARG A NH1   1 ? 
ATOM   1705 N NH2   . ARG A 1 239 ? 16.034  19.109  36.841 1.00 27.46  ? 218  ARG A NH2   1 ? 
ATOM   1706 N N     . LYS A 1 240 ? 8.905   17.826  34.720 1.00 21.54  ? 219  LYS A N     1 ? 
ATOM   1707 C CA    . LYS A 1 240 ? 7.721   18.079  35.524 1.00 23.52  ? 219  LYS A CA    1 ? 
ATOM   1708 C C     . LYS A 1 240 ? 6.941   19.239  34.911 1.00 20.63  ? 219  LYS A C     1 ? 
ATOM   1709 O O     . LYS A 1 240 ? 7.446   19.967  34.044 1.00 18.47  ? 219  LYS A O     1 ? 
ATOM   1710 C CB    . LYS A 1 240 ? 8.004   18.324  37.006 1.00 26.84  ? 219  LYS A CB    1 ? 
ATOM   1711 C CG    . LYS A 1 240 ? 8.769   19.585  37.315 1.00 28.91  ? 219  LYS A CG    1 ? 
ATOM   1712 C CD    . LYS A 1 240 ? 8.911   19.782  38.813 1.00 29.14  ? 219  LYS A CD    1 ? 
ATOM   1713 C CE    . LYS A 1 240 ? 9.601   21.065  39.049 1.00 35.10  ? 219  LYS A CE    1 ? 
ATOM   1714 N NZ    . LYS A 1 240 ? 9.846   21.285  40.475 1.00 40.06  ? 219  LYS A NZ    1 ? 
ATOM   1715 N N     . VAL A 1 241 ? 5.689   19.332  35.334 1.00 20.07  ? 220  VAL A N     1 ? 
ATOM   1716 C CA    . VAL A 1 241 ? 4.779   20.388  34.923 1.00 20.96  ? 220  VAL A CA    1 ? 
ATOM   1717 C C     . VAL A 1 241 ? 4.909   21.473  35.969 1.00 22.20  ? 220  VAL A C     1 ? 
ATOM   1718 O O     . VAL A 1 241 ? 5.121   21.161  37.136 1.00 23.28  ? 220  VAL A O     1 ? 
ATOM   1719 C CB    . VAL A 1 241 ? 3.334   19.879  34.805 1.00 22.34  ? 220  VAL A CB    1 ? 
ATOM   1720 C CG1   . VAL A 1 241 ? 2.359   20.963  34.336 1.00 22.30  ? 220  VAL A CG1   1 ? 
ATOM   1721 C CG2   . VAL A 1 241 ? 3.260   18.665  33.895 1.00 25.06  ? 220  VAL A CG2   1 ? 
ATOM   1722 N N     . LEU A 1 242 ? 4.829   22.731  35.519 1.00 24.43  ? 221  LEU A N     1 ? 
ATOM   1723 C CA    . LEU A 1 242 ? 4.970   23.879  36.412 1.00 23.80  ? 221  LEU A CA    1 ? 
ATOM   1724 C C     . LEU A 1 242 ? 3.599   24.500  36.632 1.00 22.86  ? 221  LEU A C     1 ? 
ATOM   1725 O O     . LEU A 1 242 ? 2.817   24.593  35.680 1.00 21.81  ? 221  LEU A O     1 ? 
ATOM   1726 C CB    . LEU A 1 242 ? 5.914   24.932  35.827 1.00 23.63  ? 221  LEU A CB    1 ? 
ATOM   1727 C CG    . LEU A 1 242 ? 7.335   24.446  35.525 1.00 25.03  ? 221  LEU A CG    1 ? 
ATOM   1728 C CD1   . LEU A 1 242 ? 8.100   25.531  34.768 1.00 27.26  ? 221  LEU A CD1   1 ? 
ATOM   1729 C CD2   . LEU A 1 242 ? 8.022   24.063  36.812 1.00 27.68  ? 221  LEU A CD2   1 ? 
ATOM   1730 N N     . PHE A 1 243 ? 3.379   24.968  37.870 1.00 23.18  ? 222  PHE A N     1 ? 
ATOM   1731 C CA    . PHE A 1 243 ? 2.110   25.521  38.305 1.00 26.14  ? 222  PHE A CA    1 ? 
ATOM   1732 C C     . PHE A 1 243 ? 2.287   26.901  38.942 1.00 28.26  ? 222  PHE A C     1 ? 
ATOM   1733 O O     . PHE A 1 243 ? 3.319   27.195  39.541 1.00 26.39  ? 222  PHE A O     1 ? 
ATOM   1734 C CB    . PHE A 1 243 ? 1.472   24.595  39.342 1.00 24.77  ? 222  PHE A CB    1 ? 
ATOM   1735 C CG    . PHE A 1 243 ? 1.072   23.247  38.762 1.00 24.90  ? 222  PHE A CG    1 ? 
ATOM   1736 C CD1   . PHE A 1 243 ? -0.146  23.082  38.118 1.00 26.35  ? 222  PHE A CD1   1 ? 
ATOM   1737 C CD2   . PHE A 1 243 ? 1.947   22.170  38.792 1.00 27.89  ? 222  PHE A CD2   1 ? 
ATOM   1738 C CE1   . PHE A 1 243 ? -0.502  21.861  37.572 1.00 27.19  ? 222  PHE A CE1   1 ? 
ATOM   1739 C CE2   . PHE A 1 243 ? 1.566   20.940  38.275 1.00 27.98  ? 222  PHE A CE2   1 ? 
ATOM   1740 C CZ    . PHE A 1 243 ? 0.355   20.786  37.669 1.00 26.94  ? 222  PHE A CZ    1 ? 
ATOM   1741 N N     . GLU A 1 244 ? 1.232   27.704  38.816 1.00 26.81  ? 223  GLU A N     1 ? 
ATOM   1742 C CA    . GLU A 1 244 ? 0.963   28.841  39.682 1.00 29.05  ? 223  GLU A CA    1 ? 
ATOM   1743 C C     . GLU A 1 244 ? -0.368  28.555  40.385 1.00 25.65  ? 223  GLU A C     1 ? 
ATOM   1744 O O     . GLU A 1 244 ? -1.423  28.503  39.758 1.00 24.18  ? 223  GLU A O     1 ? 
ATOM   1745 C CB    . GLU A 1 244 ? 0.872   30.108  38.830 1.00 33.50  ? 223  GLU A CB    1 ? 
ATOM   1746 C CG    . GLU A 1 244 ? 0.620   31.379  39.636 1.00 42.97  ? 223  GLU A CG    1 ? 
ATOM   1747 C CD    . GLU A 1 244 ? 0.254   32.558  38.756 1.00 52.02  ? 223  GLU A CD    1 ? 
ATOM   1748 O OE1   . GLU A 1 244 ? 0.549   32.566  37.538 1.00 57.84  ? 223  GLU A OE1   1 ? 
ATOM   1749 O OE2   . GLU A 1 244 ? -0.371  33.482  39.309 1.00 70.54  ? 223  GLU A OE2   1 ? 
ATOM   1750 N N     . GLY A 1 245 ? -0.315  28.296  41.684 1.00 25.66  ? 224  GLY A N     1 ? 
ATOM   1751 C CA    . GLY A 1 245 ? -1.454  27.712  42.365 1.00 29.90  ? 224  GLY A CA    1 ? 
ATOM   1752 C C     . GLY A 1 245 ? -1.810  26.374  41.708 1.00 30.43  ? 224  GLY A C     1 ? 
ATOM   1753 O O     . GLY A 1 245 ? -0.931  25.520  41.547 1.00 27.87  ? 224  GLY A O     1 ? 
ATOM   1754 N N     . THR A 1 246 ? -3.093  26.214  41.345 1.00 30.01  ? 225  THR A N     1 ? 
ATOM   1755 C CA    . THR A 1 246 ? -3.587  24.974  40.755 1.00 27.95  ? 225  THR A CA    1 ? 
ATOM   1756 C C     . THR A 1 246 ? -3.660  25.130  39.247 1.00 24.65  ? 225  THR A C     1 ? 
ATOM   1757 O O     . THR A 1 246 ? -4.281  24.300  38.575 1.00 26.00  ? 225  THR A O     1 ? 
ATOM   1758 C CB    . THR A 1 246 ? -4.942  24.589  41.342 1.00 27.68  ? 225  THR A CB    1 ? 
ATOM   1759 O OG1   . THR A 1 246 ? -5.820  25.701  41.150 1.00 29.57  ? 225  THR A OG1   1 ? 
ATOM   1760 C CG2   . THR A 1 246 ? -4.845  24.232  42.806 1.00 29.16  ? 225  THR A CG2   1 ? 
ATOM   1761 N N     . LYS A 1 247 ? -3.009  26.178  38.711 1.00 23.42  ? 226  LYS A N     1 ? 
ATOM   1762 C CA    . LYS A 1 247 ? -3.039  26.430  37.278 1.00 26.00  ? 226  LYS A CA    1 ? 
ATOM   1763 C C     . LYS A 1 247 ? -1.720  25.976  36.649 1.00 23.56  ? 226  LYS A C     1 ? 
ATOM   1764 O O     . LYS A 1 247 ? -0.659  26.431  37.059 1.00 23.15  ? 226  LYS A O     1 ? 
ATOM   1765 C CB    . LYS A 1 247 ? -3.218  27.930  36.987 1.00 29.95  ? 226  LYS A CB    1 ? 
ATOM   1766 C CG    . LYS A 1 247 ? -3.587  28.243  35.564 1.00 34.32  ? 226  LYS A CG    1 ? 
ATOM   1767 C CD    . LYS A 1 247 ? -3.502  29.716  35.172 1.00 38.15  ? 226  LYS A CD    1 ? 
ATOM   1768 C CE    . LYS A 1 247 ? -4.119  29.903  33.831 1.00 42.70  ? 226  LYS A CE    1 ? 
ATOM   1769 N NZ    . LYS A 1 247 ? -3.309  30.808  33.003 1.00 52.57  ? 226  LYS A NZ    1 ? 
ATOM   1770 N N     . ALA A 1 248 ? -1.802  25.135  35.618 1.00 23.05  ? 227  ALA A N     1 ? 
ATOM   1771 C CA    . ALA A 1 248 ? -0.617  24.687  34.889 1.00 24.07  ? 227  ALA A CA    1 ? 
ATOM   1772 C C     . ALA A 1 248 ? -0.163  25.782  33.924 1.00 23.22  ? 227  ALA A C     1 ? 
ATOM   1773 O O     . ALA A 1 248 ? -0.969  26.244  33.112 1.00 26.49  ? 227  ALA A O     1 ? 
ATOM   1774 C CB    . ALA A 1 248 ? -0.912  23.396  34.162 1.00 21.99  ? 227  ALA A CB    1 ? 
ATOM   1775 N N     . ILE A 1 249 ? 1.107   26.204  34.045 1.00 23.63  ? 228  ILE A N     1 ? 
ATOM   1776 C CA    . ILE A 1 249 ? 1.621   27.333  33.283 1.00 22.08  ? 228  ILE A CA    1 ? 
ATOM   1777 C C     . ILE A 1 249 ? 2.795   26.979  32.380 1.00 25.49  ? 228  ILE A C     1 ? 
ATOM   1778 O O     . ILE A 1 249 ? 3.099   27.770  31.480 1.00 23.70  ? 228  ILE A O     1 ? 
ATOM   1779 C CB    . ILE A 1 249 ? 2.021   28.490  34.208 1.00 24.88  ? 228  ILE A CB    1 ? 
ATOM   1780 C CG1   . ILE A 1 249 ? 3.091   28.097  35.229 1.00 23.67  ? 228  ILE A CG1   1 ? 
ATOM   1781 C CG2   . ILE A 1 249 ? 0.765   29.085  34.861 1.00 26.33  ? 228  ILE A CG2   1 ? 
ATOM   1782 C CD1   . ILE A 1 249 ? 3.817   29.304  35.824 1.00 27.31  ? 228  ILE A CD1   1 ? 
ATOM   1783 N N     . GLY A 1 250 ? 3.461   25.828  32.616 1.00 25.12  ? 229  GLY A N     1 ? 
ATOM   1784 C CA    . GLY A 1 250 ? 4.642   25.488  31.839 1.00 23.32  ? 229  GLY A CA    1 ? 
ATOM   1785 C C     . GLY A 1 250 ? 5.176   24.097  32.171 1.00 23.23  ? 229  GLY A C     1 ? 
ATOM   1786 O O     . GLY A 1 250 ? 4.484   23.295  32.823 1.00 22.73  ? 229  GLY A O     1 ? 
ATOM   1787 N N     . VAL A 1 251 ? 6.392   23.821  31.665 1.00 23.14  ? 230  VAL A N     1 ? 
ATOM   1788 C CA    . VAL A 1 251 ? 7.129   22.601  31.953 1.00 23.29  ? 230  VAL A CA    1 ? 
ATOM   1789 C C     . VAL A 1 251 ? 8.591   22.912  32.221 1.00 23.66  ? 230  VAL A C     1 ? 
ATOM   1790 O O     . VAL A 1 251 ? 9.145   23.875  31.669 1.00 24.07  ? 230  VAL A O     1 ? 
ATOM   1791 C CB    . VAL A 1 251 ? 6.998   21.575  30.808 1.00 24.48  ? 230  VAL A CB    1 ? 
ATOM   1792 C CG1   . VAL A 1 251 ? 5.561   21.106  30.634 1.00 22.82  ? 230  VAL A CG1   1 ? 
ATOM   1793 C CG2   . VAL A 1 251 ? 7.494   22.114  29.482 1.00 23.57  ? 230  VAL A CG2   1 ? 
ATOM   1794 N N     . GLU A 1 252 ? 9.199   22.072  33.079 1.00 21.42  ? 231  GLU A N     1 ? 
ATOM   1795 C CA    . GLU A 1 252 ? 10.639  22.026  33.231 1.00 24.08  ? 231  GLU A CA    1 ? 
ATOM   1796 C C     . GLU A 1 252 ? 11.194  20.944  32.296 1.00 26.13  ? 231  GLU A C     1 ? 
ATOM   1797 O O     . GLU A 1 252 ? 10.805  19.768  32.373 1.00 26.06  ? 231  GLU A O     1 ? 
ATOM   1798 C CB    . GLU A 1 252 ? 11.017  21.763  34.683 1.00 24.89  ? 231  GLU A CB    1 ? 
ATOM   1799 C CG    . GLU A 1 252 ? 12.522  21.699  34.931 1.00 25.26  ? 231  GLU A CG    1 ? 
ATOM   1800 C CD    . GLU A 1 252 ? 12.817  21.229  36.330 1.00 26.43  ? 231  GLU A CD    1 ? 
ATOM   1801 O OE1   . GLU A 1 252 ? 13.190  20.046  36.535 1.00 26.55  ? 231  GLU A OE1   1 ? 
ATOM   1802 O OE2   . GLU A 1 252 ? 12.652  22.091  37.219 1.00 27.56  ? 231  GLU A OE2   1 ? 
ATOM   1803 N N     . VAL A 1 253 ? 12.084  21.346  31.397 1.00 22.69  ? 232  VAL A N     1 ? 
ATOM   1804 C CA    . VAL A 1 253 ? 12.501  20.461  30.329 1.00 21.44  ? 232  VAL A CA    1 ? 
ATOM   1805 C C     . VAL A 1 253 ? 14.008  20.528  30.155 1.00 24.74  ? 232  VAL A C     1 ? 
ATOM   1806 O O     . VAL A 1 253 ? 14.633  21.607  30.174 1.00 19.06  ? 232  VAL A O     1 ? 
ATOM   1807 C CB    . VAL A 1 253 ? 11.739  20.812  29.040 1.00 22.88  ? 232  VAL A CB    1 ? 
ATOM   1808 C CG1   . VAL A 1 253 ? 11.994  22.250  28.587 1.00 26.84  ? 232  VAL A CG1   1 ? 
ATOM   1809 C CG2   . VAL A 1 253 ? 12.077  19.845  27.919 1.00 22.75  ? 232  VAL A CG2   1 ? 
ATOM   1810 N N     . GLU A 1 254 ? 14.592  19.343  29.988 1.00 25.75  ? 233  GLU A N     1 ? 
ATOM   1811 C CA    . GLU A 1 254 ? 16.005  19.237  29.709 1.00 28.11  ? 233  GLU A CA    1 ? 
ATOM   1812 C C     . GLU A 1 254 ? 16.220  19.124  28.213 1.00 30.19  ? 233  GLU A C     1 ? 
ATOM   1813 O O     . GLU A 1 254 ? 15.745  18.174  27.590 1.00 27.48  ? 233  GLU A O     1 ? 
ATOM   1814 C CB    . GLU A 1 254 ? 16.637  18.025  30.364 1.00 28.68  ? 233  GLU A CB    1 ? 
ATOM   1815 C CG    . GLU A 1 254 ? 18.112  17.936  29.988 1.00 28.40  ? 233  GLU A CG    1 ? 
ATOM   1816 C CD    . GLU A 1 254 ? 18.630  16.543  30.014 1.00 26.41  ? 233  GLU A CD    1 ? 
ATOM   1817 O OE1   . GLU A 1 254 ? 19.632  16.313  29.315 1.00 27.66  ? 233  GLU A OE1   1 ? 
ATOM   1818 O OE2   . GLU A 1 254 ? 18.102  15.761  30.814 1.00 29.00  ? 233  GLU A OE2   1 ? 
ATOM   1819 N N     . ILE A 1 255 ? 16.976  20.089  27.683 1.00 28.54  ? 234  ILE A N     1 ? 
ATOM   1820 C CA    . ILE A 1 255 ? 17.355  20.116  26.286 1.00 33.07  ? 234  ILE A CA    1 ? 
ATOM   1821 C C     . ILE A 1 255 ? 18.873  20.105  26.233 1.00 36.63  ? 234  ILE A C     1 ? 
ATOM   1822 O O     . ILE A 1 255 ? 19.504  21.092  26.598 1.00 30.76  ? 234  ILE A O     1 ? 
ATOM   1823 C CB    . ILE A 1 255 ? 16.742  21.339  25.582 1.00 37.63  ? 234  ILE A CB    1 ? 
ATOM   1824 C CG1   . ILE A 1 255 ? 15.233  21.252  25.599 1.00 37.11  ? 234  ILE A CG1   1 ? 
ATOM   1825 C CG2   . ILE A 1 255 ? 17.297  21.500  24.166 1.00 39.92  ? 234  ILE A CG2   1 ? 
ATOM   1826 C CD1   . ILE A 1 255 ? 14.502  22.552  25.352 1.00 41.66  ? 234  ILE A CD1   1 ? 
ATOM   1827 N N     . ASP A 1 256 ? 19.428  18.951  25.823 1.00 38.31  ? 235  ASP A N     1 ? 
ATOM   1828 C CA    . ASP A 1 256 ? 20.839  18.795  25.525 1.00 39.73  ? 235  ASP A CA    1 ? 
ATOM   1829 C C     . ASP A 1 256 ? 21.658  19.043  26.792 1.00 34.61  ? 235  ASP A C     1 ? 
ATOM   1830 O O     . ASP A 1 256 ? 22.613  19.801  26.755 1.00 34.09  ? 235  ASP A O     1 ? 
ATOM   1831 C CB    . ASP A 1 256 ? 21.251  19.707  24.377 1.00 43.63  ? 235  ASP A CB    1 ? 
ATOM   1832 C CG    . ASP A 1 256 ? 20.627  19.407  23.019 1.00 50.17  ? 235  ASP A CG    1 ? 
ATOM   1833 O OD1   . ASP A 1 256 ? 20.100  18.288  22.858 1.00 52.53  ? 235  ASP A OD1   1 ? 
ATOM   1834 O OD2   . ASP A 1 256 ? 20.674  20.302  22.133 1.00 49.88  ? 235  ASP A OD2   1 ? 
ATOM   1835 N N     . GLY A 1 257 ? 21.278  18.414  27.909 1.00 27.27  ? 236  GLY A N     1 ? 
ATOM   1836 C CA    . GLY A 1 257 ? 22.051  18.482  29.132 1.00 24.43  ? 236  GLY A CA    1 ? 
ATOM   1837 C C     . GLY A 1 257 ? 21.905  19.787  29.908 1.00 22.63  ? 236  GLY A C     1 ? 
ATOM   1838 O O     . GLY A 1 257 ? 22.588  19.964  30.916 1.00 27.94  ? 236  GLY A O     1 ? 
ATOM   1839 N N     . GLN A 1 258 ? 20.987  20.673  29.493 1.00 21.89  ? 237  GLN A N     1 ? 
ATOM   1840 C CA    . GLN A 1 258 ? 20.677  21.854  30.280 1.00 21.63  ? 237  GLN A CA    1 ? 
ATOM   1841 C C     . GLN A 1 258 ? 19.164  22.068  30.418 1.00 21.93  ? 237  GLN A C     1 ? 
ATOM   1842 O O     . GLN A 1 258 ? 18.381  21.736  29.535 1.00 21.26  ? 237  GLN A O     1 ? 
ATOM   1843 C CB    . GLN A 1 258 ? 21.331  23.097  29.652 1.00 21.22  ? 237  GLN A CB    1 ? 
ATOM   1844 C CG    . GLN A 1 258 ? 22.853  23.014  29.565 1.00 20.44  ? 237  GLN A CG    1 ? 
ATOM   1845 C CD    . GLN A 1 258 ? 23.499  24.198  28.875 1.00 22.63  ? 237  GLN A CD    1 ? 
ATOM   1846 O OE1   . GLN A 1 258 ? 23.506  24.316  27.642 1.00 19.21  ? 237  GLN A OE1   1 ? 
ATOM   1847 N NE2   . GLN A 1 258 ? 24.119  25.056  29.676 1.00 22.72  ? 237  GLN A NE2   1 ? 
ATOM   1848 N N     . ILE A 1 259 ? 18.758  22.646  31.554 1.00 21.35  ? 238  ILE A N     1 ? 
ATOM   1849 C CA    . ILE A 1 259 ? 17.358  22.688  31.941 1.00 22.51  ? 238  ILE A CA    1 ? 
ATOM   1850 C C     . ILE A 1 259 ? 16.787  24.073  31.640 1.00 22.14  ? 238  ILE A C     1 ? 
ATOM   1851 O O     . ILE A 1 259 ? 17.420  25.072  31.898 1.00 20.85  ? 238  ILE A O     1 ? 
ATOM   1852 C CB    . ILE A 1 259 ? 17.239  22.298  33.423 1.00 24.57  ? 238  ILE A CB    1 ? 
ATOM   1853 C CG1   . ILE A 1 259 ? 17.796  20.891  33.604 1.00 26.62  ? 238  ILE A CG1   1 ? 
ATOM   1854 C CG2   . ILE A 1 259 ? 15.811  22.418  33.948 1.00 26.80  ? 238  ILE A CG2   1 ? 
ATOM   1855 C CD1   . ILE A 1 259 ? 18.201  20.601  35.015 1.00 31.13  ? 238  ILE A CD1   1 ? 
ATOM   1856 N N     . GLN A 1 260 ? 15.607  24.100  31.031 1.00 21.33  ? 239  GLN A N     1 ? 
ATOM   1857 C CA    . GLN A 1 260 ? 14.852  25.305  30.732 1.00 24.10  ? 239  GLN A CA    1 ? 
ATOM   1858 C C     . GLN A 1 260 ? 13.445  25.173  31.293 1.00 25.68  ? 239  GLN A C     1 ? 
ATOM   1859 O O     . GLN A 1 260 ? 12.927  24.048  31.431 1.00 23.63  ? 239  GLN A O     1 ? 
ATOM   1860 C CB    . GLN A 1 260 ? 14.746  25.515  29.229 1.00 25.12  ? 239  GLN A CB    1 ? 
ATOM   1861 C CG    . GLN A 1 260 ? 16.088  25.789  28.558 1.00 26.13  ? 239  GLN A CG    1 ? 
ATOM   1862 C CD    . GLN A 1 260 ? 15.944  26.006  27.069 1.00 24.84  ? 239  GLN A CD    1 ? 
ATOM   1863 O OE1   . GLN A 1 260 ? 15.142  26.829  26.654 1.00 27.89  ? 239  GLN A OE1   1 ? 
ATOM   1864 N NE2   . GLN A 1 260 ? 16.651  25.253  26.244 1.00 24.37  ? 239  GLN A NE2   1 ? 
ATOM   1865 N N     . ASN A 1 261 ? 12.831  26.325  31.605 1.00 25.00  ? 240  ASN A N     1 ? 
ATOM   1866 C CA    . ASN A 1 261 ? 11.392  26.369  31.841 1.00 23.91  ? 240  ASN A CA    1 ? 
ATOM   1867 C C     . ASN A 1 261 ? 10.725  26.949  30.611 1.00 27.33  ? 240  ASN A C     1 ? 
ATOM   1868 O O     . ASN A 1 261 ? 11.136  27.995  30.139 1.00 27.47  ? 240  ASN A O     1 ? 
ATOM   1869 C CB    . ASN A 1 261 ? 11.031  27.184  33.070 1.00 26.60  ? 240  ASN A CB    1 ? 
ATOM   1870 C CG    . ASN A 1 261 ? 11.632  26.582  34.319 1.00 26.92  ? 240  ASN A CG    1 ? 
ATOM   1871 O OD1   . ASN A 1 261 ? 11.671  25.363  34.504 1.00 25.83  ? 240  ASN A OD1   1 ? 
ATOM   1872 N ND2   . ASN A 1 261 ? 12.183  27.411  35.176 1.00 28.85  ? 240  ASN A ND2   1 ? 
ATOM   1873 N N     . MET A 1 262 ? 9.765   26.228  30.044 1.00 25.06  ? 241  MET A N     1 ? 
ATOM   1874 C CA    . MET A 1 262 ? 9.001   26.709  28.910 1.00 25.97  ? 241  MET A CA    1 ? 
ATOM   1875 C C     . MET A 1 262 ? 7.531   26.877  29.315 1.00 27.97  ? 241  MET A C     1 ? 
ATOM   1876 O O     . MET A 1 262 ? 7.013   26.065  30.078 1.00 26.02  ? 241  MET A O     1 ? 
ATOM   1877 C CB    . MET A 1 262 ? 9.213   25.780  27.717 1.00 27.43  ? 241  MET A CB    1 ? 
ATOM   1878 C CG    . MET A 1 262 ? 10.613  25.943  27.148 1.00 35.63  ? 241  MET A CG    1 ? 
ATOM   1879 S SD    . MET A 1 262 ? 10.994  24.807  25.800 1.00 47.15  ? 241  MET A SD    1 ? 
ATOM   1880 C CE    . MET A 1 262 ? 12.693  25.319  25.513 1.00 56.71  ? 241  MET A CE    1 ? 
ATOM   1881 N N     . TYR A 1 263 ? 6.879   27.934  28.800 1.00 26.82  ? 242  TYR A N     1 ? 
ATOM   1882 C CA    . TYR A 1 263 ? 5.593   28.384  29.296 1.00 27.25  ? 242  TYR A CA    1 ? 
ATOM   1883 C C     . TYR A 1 263 ? 4.550   28.408  28.184 1.00 27.18  ? 242  TYR A C     1 ? 
ATOM   1884 O O     . TYR A 1 263 ? 4.856   28.615  27.007 1.00 26.15  ? 242  TYR A O     1 ? 
ATOM   1885 C CB    . TYR A 1 263 ? 5.729   29.748  29.988 1.00 27.73  ? 242  TYR A CB    1 ? 
ATOM   1886 C CG    . TYR A 1 263 ? 6.583   29.688  31.243 1.00 23.89  ? 242  TYR A CG    1 ? 
ATOM   1887 C CD1   . TYR A 1 263 ? 6.066   29.241  32.452 1.00 24.03  ? 242  TYR A CD1   1 ? 
ATOM   1888 C CD2   . TYR A 1 263 ? 7.939   29.993  31.190 1.00 26.03  ? 242  TYR A CD2   1 ? 
ATOM   1889 C CE1   . TYR A 1 263 ? 6.855   29.159  33.585 1.00 25.62  ? 242  TYR A CE1   1 ? 
ATOM   1890 C CE2   . TYR A 1 263 ? 8.732   29.962  32.318 1.00 24.22  ? 242  TYR A CE2   1 ? 
ATOM   1891 C CZ    . TYR A 1 263 ? 8.190   29.536  33.515 1.00 25.30  ? 242  TYR A CZ    1 ? 
ATOM   1892 O OH    . TYR A 1 263 ? 8.991   29.453  34.608 1.00 26.39  ? 242  TYR A OH    1 ? 
ATOM   1893 N N     . ALA A 1 264 ? 3.302   28.175  28.602 1.00 27.10  ? 243  ALA A N     1 ? 
ATOM   1894 C CA    . ALA A 1 264 ? 2.144   28.227  27.726 1.00 27.93  ? 243  ALA A CA    1 ? 
ATOM   1895 C C     . ALA A 1 264 ? 1.104   29.182  28.306 1.00 26.28  ? 243  ALA A C     1 ? 
ATOM   1896 O O     . ALA A 1 264 ? 0.767   29.100  29.486 1.00 27.10  ? 243  ALA A O     1 ? 
ATOM   1897 C CB    . ALA A 1 264 ? 1.548   26.844  27.593 1.00 28.42  ? 243  ALA A CB    1 ? 
ATOM   1898 N N     . SER A 1 265 ? 0.522   30.016  27.447 1.00 28.41  ? 244  SER A N     1 ? 
ATOM   1899 C CA    . SER A 1 265 ? -0.465  30.985  27.900 1.00 27.77  ? 244  SER A CA    1 ? 
ATOM   1900 C C     . SER A 1 265 ? -1.858  30.344  28.054 1.00 27.56  ? 244  SER A C     1 ? 
ATOM   1901 O O     . SER A 1 265 ? -2.692  30.846  28.800 1.00 28.11  ? 244  SER A O     1 ? 
ATOM   1902 C CB    . SER A 1 265 ? -0.475  32.150  26.950 1.00 28.09  ? 244  SER A CB    1 ? 
ATOM   1903 O OG    . SER A 1 265 ? -0.972  31.734  25.691 1.00 29.79  ? 244  SER A OG    1 ? 
ATOM   1904 N N     . LYS A 1 266 ? -2.131  29.225  27.371 1.00 26.90  ? 245  LYS A N     1 ? 
ATOM   1905 C CA    . LYS A 1 266 ? -3.426  28.559  27.510 1.00 27.00  ? 245  LYS A CA    1 ? 
ATOM   1906 C C     . LYS A 1 266 ? -3.310  27.254  28.300 1.00 25.57  ? 245  LYS A C     1 ? 
ATOM   1907 O O     . LYS A 1 266 ? -3.824  27.176  29.402 1.00 25.31  ? 245  LYS A O     1 ? 
ATOM   1908 C CB    . LYS A 1 266 ? -4.065  28.370  26.133 1.00 31.50  ? 245  LYS A CB    1 ? 
ATOM   1909 C CG    . LYS A 1 266 ? -4.323  29.707  25.441 1.00 36.49  ? 245  LYS A CG    1 ? 
ATOM   1910 C CD    . LYS A 1 266 ? -5.360  29.727  24.335 1.00 45.73  ? 245  LYS A CD    1 ? 
ATOM   1911 C CE    . LYS A 1 266 ? -5.789  31.170  24.113 1.00 53.81  ? 245  LYS A CE    1 ? 
ATOM   1912 N NZ    . LYS A 1 266 ? -7.116  31.233  23.497 1.00 63.53  ? 245  LYS A NZ    1 ? 
ATOM   1913 N N     . GLU A 1 267 ? -2.620  26.233  27.765 1.00 24.14  ? 246  GLU A N     1 ? 
ATOM   1914 C CA    . GLU A 1 267 ? -2.645  24.946  28.439 1.00 23.43  ? 246  GLU A CA    1 ? 
ATOM   1915 C C     . GLU A 1 267 ? -1.427  24.082  28.135 1.00 22.60  ? 246  GLU A C     1 ? 
ATOM   1916 O O     . GLU A 1 267 ? -0.734  24.282  27.135 1.00 18.66  ? 246  GLU A O     1 ? 
ATOM   1917 C CB    . GLU A 1 267 ? -3.837  24.145  27.913 1.00 24.97  ? 246  GLU A CB    1 ? 
ATOM   1918 C CG    . GLU A 1 267 ? -5.186  24.853  28.027 1.00 29.27  ? 246  GLU A CG    1 ? 
ATOM   1919 C CD    . GLU A 1 267 ? -6.404  23.962  27.880 1.00 33.42  ? 246  GLU A CD    1 ? 
ATOM   1920 O OE1   . GLU A 1 267 ? -7.231  24.258  27.010 1.00 33.39  ? 246  GLU A OE1   1 ? 
ATOM   1921 O OE2   . GLU A 1 267 ? -6.560  23.010  28.683 1.00 41.76  ? 246  GLU A OE2   1 ? 
ATOM   1922 N N     . ILE A 1 268 ? -1.212  23.130  29.047 1.00 21.46  ? 247  ILE A N     1 ? 
ATOM   1923 C CA    . ILE A 1 268 ? -0.261  22.039  28.900 1.00 21.11  ? 247  ILE A CA    1 ? 
ATOM   1924 C C     . ILE A 1 268 ? -1.034  20.747  28.602 1.00 22.15  ? 247  ILE A C     1 ? 
ATOM   1925 O O     . ILE A 1 268 ? -2.019  20.452  29.280 1.00 23.62  ? 247  ILE A O     1 ? 
ATOM   1926 C CB    . ILE A 1 268 ? 0.564   21.888  30.190 1.00 19.63  ? 247  ILE A CB    1 ? 
ATOM   1927 C CG1   . ILE A 1 268 ? 1.219   23.223  30.674 1.00 22.27  ? 247  ILE A CG1   1 ? 
ATOM   1928 C CG2   . ILE A 1 268 ? 1.639   20.797  30.035 1.00 19.32  ? 247  ILE A CG2   1 ? 
ATOM   1929 C CD1   . ILE A 1 268 ? 2.134   23.870  29.653 1.00 22.65  ? 247  ILE A CD1   1 ? 
ATOM   1930 N N     . ILE A 1 269 ? -0.567  19.978  27.612 1.00 21.04  ? 248  ILE A N     1 ? 
ATOM   1931 C CA    . ILE A 1 269 ? -1.189  18.737  27.190 1.00 22.25  ? 248  ILE A CA    1 ? 
ATOM   1932 C C     . ILE A 1 269 ? -0.152  17.618  27.334 1.00 24.02  ? 248  ILE A C     1 ? 
ATOM   1933 O O     . ILE A 1 269 ? 0.932   17.688  26.740 1.00 22.51  ? 248  ILE A O     1 ? 
ATOM   1934 C CB    . ILE A 1 269 ? -1.703  18.860  25.748 1.00 22.30  ? 248  ILE A CB    1 ? 
ATOM   1935 C CG1   . ILE A 1 269 ? -2.665  20.055  25.607 1.00 24.06  ? 248  ILE A CG1   1 ? 
ATOM   1936 C CG2   . ILE A 1 269 ? -2.346  17.545  25.276 1.00 24.43  ? 248  ILE A CG2   1 ? 
ATOM   1937 C CD1   . ILE A 1 269 ? -2.977  20.419  24.171 1.00 25.92  ? 248  ILE A CD1   1 ? 
ATOM   1938 N N     . LEU A 1 270 ? -0.464  16.626  28.174 1.00 22.40  ? 249  LEU A N     1 ? 
ATOM   1939 C CA    . LEU A 1 270 ? 0.427   15.485  28.365 1.00 22.58  ? 249  LEU A CA    1 ? 
ATOM   1940 C C     . LEU A 1 270 ? 0.034   14.371  27.401 1.00 19.36  ? 249  LEU A C     1 ? 
ATOM   1941 O O     . LEU A 1 270 ? -1.110  13.910  27.390 1.00 18.84  ? 249  LEU A O     1 ? 
ATOM   1942 C CB    . LEU A 1 270 ? 0.321   15.027  29.817 1.00 21.21  ? 249  LEU A CB    1 ? 
ATOM   1943 C CG    . LEU A 1 270 ? 0.783   16.037  30.865 1.00 23.18  ? 249  LEU A CG    1 ? 
ATOM   1944 C CD1   . LEU A 1 270 ? 0.800   15.381  32.233 1.00 22.65  ? 249  LEU A CD1   1 ? 
ATOM   1945 C CD2   . LEU A 1 270 ? 2.164   16.655  30.551 1.00 25.37  ? 249  LEU A CD2   1 ? 
ATOM   1946 N N     . SER A 1 271 ? 0.986   13.963  26.581 1.00 20.54  ? 250  SER A N     1 ? 
ATOM   1947 C CA    . SER A 1 271 ? 0.812   12.889  25.626 1.00 19.62  ? 250  SER A CA    1 ? 
ATOM   1948 C C     . SER A 1 271 ? 2.020   11.962  25.726 1.00 17.80  ? 250  SER A C     1 ? 
ATOM   1949 O O     . SER A 1 271 ? 2.525   11.498  24.724 1.00 19.84  ? 250  SER A O     1 ? 
ATOM   1950 C CB    . SER A 1 271 ? 0.599   13.444  24.223 1.00 23.52  ? 250  SER A CB    1 ? 
ATOM   1951 O OG    . SER A 1 271 ? -0.557  14.282  24.139 1.00 22.00  ? 250  SER A OG    1 ? 
ATOM   1952 N N     . ALA A 1 272 ? 2.462   11.689  26.962 1.00 18.35  ? 251  ALA A N     1 ? 
ATOM   1953 C CA    . ALA A 1 272 ? 3.709   10.965  27.211 1.00 19.65  ? 251  ALA A CA    1 ? 
ATOM   1954 C C     . ALA A 1 272 ? 3.499   9.457   27.319 1.00 17.88  ? 251  ALA A C     1 ? 
ATOM   1955 O O     . ALA A 1 272 ? 4.480   8.728   27.550 1.00 20.44  ? 251  ALA A O     1 ? 
ATOM   1956 C CB    . ALA A 1 272 ? 4.379   11.475  28.471 1.00 18.25  ? 251  ALA A CB    1 ? 
ATOM   1957 N N     . GLY A 1 273 ? 2.241   9.015   27.159 1.00 18.11  ? 252  GLY A N     1 ? 
ATOM   1958 C CA    . GLY A 1 273 ? 1.877   7.602   27.147 1.00 18.25  ? 252  GLY A CA    1 ? 
ATOM   1959 C C     . GLY A 1 273 ? 1.533   7.041   28.535 1.00 18.77  ? 252  GLY A C     1 ? 
ATOM   1960 O O     . GLY A 1 273 ? 1.712   7.695   29.578 1.00 17.82  ? 252  GLY A O     1 ? 
ATOM   1961 N N     . THR A 1 274 ? 1.085   5.776   28.535 1.00 17.62  ? 253  THR A N     1 ? 
ATOM   1962 C CA    . THR A 1 274 ? 0.548   5.144   29.741 1.00 17.35  ? 253  THR A CA    1 ? 
ATOM   1963 C C     . THR A 1 274 ? 1.565   5.105   30.882 1.00 17.50  ? 253  THR A C     1 ? 
ATOM   1964 O O     . THR A 1 274 ? 1.185   5.156   32.039 1.00 18.57  ? 253  THR A O     1 ? 
ATOM   1965 C CB    . THR A 1 274 ? 0.035   3.746   29.405 1.00 17.38  ? 253  THR A CB    1 ? 
ATOM   1966 O OG1   . THR A 1 274 ? -0.980  3.952   28.418 1.00 16.08  ? 253  THR A OG1   1 ? 
ATOM   1967 C CG2   . THR A 1 274 ? -0.523  3.050   30.636 1.00 17.86  ? 253  THR A CG2   1 ? 
ATOM   1968 N N     . PHE A 1 275 ? 2.850   4.926   30.579 1.00 18.66  ? 254  PHE A N     1 ? 
ATOM   1969 C CA    . PHE A 1 275 ? 3.849   4.787   31.626 1.00 19.14  ? 254  PHE A CA    1 ? 
ATOM   1970 C C     . PHE A 1 275 ? 4.312   6.159   32.134 1.00 17.67  ? 254  PHE A C     1 ? 
ATOM   1971 O O     . PHE A 1 275 ? 4.393   6.374   33.364 1.00 17.32  ? 254  PHE A O     1 ? 
ATOM   1972 C CB    . PHE A 1 275 ? 5.030   3.937   31.139 1.00 18.20  ? 254  PHE A CB    1 ? 
ATOM   1973 C CG    . PHE A 1 275 ? 4.713   2.529   30.663 1.00 18.13  ? 254  PHE A CG    1 ? 
ATOM   1974 C CD1   . PHE A 1 275 ? 3.788   1.732   31.318 1.00 18.52  ? 254  PHE A CD1   1 ? 
ATOM   1975 C CD2   . PHE A 1 275 ? 5.323   2.016   29.531 1.00 17.56  ? 254  PHE A CD2   1 ? 
ATOM   1976 C CE1   . PHE A 1 275 ? 3.518   0.441   30.891 1.00 20.12  ? 254  PHE A CE1   1 ? 
ATOM   1977 C CE2   . PHE A 1 275 ? 5.039   0.723   29.105 1.00 18.44  ? 254  PHE A CE2   1 ? 
ATOM   1978 C CZ    . PHE A 1 275 ? 4.143   -0.055  29.774 1.00 18.21  ? 254  PHE A CZ    1 ? 
ATOM   1979 N N     . ASN A 1 276 ? 4.631   7.078   31.216 1.00 18.26  ? 255  ASN A N     1 ? 
ATOM   1980 C CA    . ASN A 1 276 ? 5.325   8.315   31.603 1.00 18.14  ? 255  ASN A CA    1 ? 
ATOM   1981 C C     . ASN A 1 276 ? 4.355   9.449   31.988 1.00 19.72  ? 255  ASN A C     1 ? 
ATOM   1982 O O     . ASN A 1 276 ? 4.744   10.324  32.785 1.00 16.85  ? 255  ASN A O     1 ? 
ATOM   1983 C CB    . ASN A 1 276 ? 6.350   8.763   30.561 1.00 17.42  ? 255  ASN A CB    1 ? 
ATOM   1984 C CG    . ASN A 1 276 ? 7.581   7.879   30.529 1.00 18.00  ? 255  ASN A CG    1 ? 
ATOM   1985 O OD1   . ASN A 1 276 ? 7.698   6.927   31.296 1.00 21.65  ? 255  ASN A OD1   1 ? 
ATOM   1986 N ND2   . ASN A 1 276 ? 8.553   8.187   29.689 1.00 20.61  ? 255  ASN A ND2   1 ? 
ATOM   1987 N N     . THR A 1 277 ? 3.131   9.476   31.424 1.00 17.53  ? 256  THR A N     1 ? 
ATOM   1988 C CA    . THR A 1 277 ? 2.144   10.501  31.794 1.00 18.04  ? 256  THR A CA    1 ? 
ATOM   1989 C C     . THR A 1 277 ? 1.873   10.465  33.307 1.00 18.39  ? 256  THR A C     1 ? 
ATOM   1990 O O     . THR A 1 277 ? 2.002   11.486  33.995 1.00 19.11  ? 256  THR A O     1 ? 
ATOM   1991 C CB    . THR A 1 277 ? 0.860   10.393  30.977 1.00 18.20  ? 256  THR A CB    1 ? 
ATOM   1992 O OG1   . THR A 1 277 ? 1.115   10.970  29.688 1.00 19.30  ? 256  THR A OG1   1 ? 
ATOM   1993 C CG2   . THR A 1 277 ? -0.309  11.147  31.597 1.00 18.01  ? 256  THR A CG2   1 ? 
ATOM   1994 N N     . PRO A 1 278 ? 1.457   9.323   33.903 1.00 18.58  ? 257  PRO A N     1 ? 
ATOM   1995 C CA    . PRO A 1 278 ? 1.207   9.280   35.345 1.00 16.62  ? 257  PRO A CA    1 ? 
ATOM   1996 C C     . PRO A 1 278 ? 2.429   9.607   36.175 1.00 18.06  ? 257  PRO A C     1 ? 
ATOM   1997 O O     . PRO A 1 278 ? 2.285   10.214  37.246 1.00 19.61  ? 257  PRO A O     1 ? 
ATOM   1998 C CB    . PRO A 1 278 ? 0.710   7.864   35.609 1.00 16.49  ? 257  PRO A CB    1 ? 
ATOM   1999 C CG    . PRO A 1 278 ? 1.214   7.083   34.388 1.00 17.25  ? 257  PRO A CG    1 ? 
ATOM   2000 C CD    . PRO A 1 278 ? 1.135   8.035   33.250 1.00 16.44  ? 257  PRO A CD    1 ? 
ATOM   2001 N N     . LYS A 1 279 ? 3.614   9.148   35.737 1.00 19.01  ? 258  LYS A N     1 ? 
ATOM   2002 C CA    . LYS A 1 279 ? 4.861   9.510   36.409 1.00 20.07  ? 258  LYS A CA    1 ? 
ATOM   2003 C C     . LYS A 1 279 ? 5.025   11.042  36.489 1.00 21.45  ? 258  LYS A C     1 ? 
ATOM   2004 O O     . LYS A 1 279 ? 5.364   11.600  37.538 1.00 19.94  ? 258  LYS A O     1 ? 
ATOM   2005 C CB    . LYS A 1 279 ? 6.055   8.859   35.694 1.00 20.99  ? 258  LYS A CB    1 ? 
ATOM   2006 C CG    . LYS A 1 279 ? 7.421   9.364   36.145 1.00 20.39  ? 258  LYS A CG    1 ? 
ATOM   2007 C CD    . LYS A 1 279 ? 8.645   8.680   35.552 1.00 20.05  ? 258  LYS A CD    1 ? 
ATOM   2008 C CE    . LYS A 1 279 ? 9.861   9.523   35.655 1.00 21.37  ? 258  LYS A CE    1 ? 
ATOM   2009 N NZ    . LYS A 1 279 ? 11.037  8.897   35.031 1.00 22.04  ? 258  LYS A NZ    1 ? 
ATOM   2010 N N     . LEU A 1 280 ? 4.839   11.718  35.356 1.00 18.67  ? 259  LEU A N     1 ? 
ATOM   2011 C CA    . LEU A 1 280 ? 5.004   13.171  35.267 1.00 22.35  ? 259  LEU A CA    1 ? 
ATOM   2012 C C     . LEU A 1 280 ? 3.993   13.871  36.178 1.00 21.33  ? 259  LEU A C     1 ? 
ATOM   2013 O O     . LEU A 1 280 ? 4.319   14.818  36.885 1.00 18.83  ? 259  LEU A O     1 ? 
ATOM   2014 C CB    . LEU A 1 280 ? 4.774   13.493  33.795 1.00 26.08  ? 259  LEU A CB    1 ? 
ATOM   2015 C CG    . LEU A 1 280 ? 5.853   14.235  33.003 1.00 32.32  ? 259  LEU A CG    1 ? 
ATOM   2016 C CD1   . LEU A 1 280 ? 7.297   14.185  33.457 1.00 29.50  ? 259  LEU A CD1   1 ? 
ATOM   2017 C CD2   . LEU A 1 280 ? 5.775   13.734  31.572 1.00 26.44  ? 259  LEU A CD2   1 ? 
ATOM   2018 N N     . LEU A 1 281 ? 2.746   13.395  36.153 1.00 19.96  ? 260  LEU A N     1 ? 
ATOM   2019 C CA    . LEU A 1 281 ? 1.695   13.939  36.997 1.00 20.30  ? 260  LEU A CA    1 ? 
ATOM   2020 C C     . LEU A 1 281 ? 2.111   13.844  38.472 1.00 21.09  ? 260  LEU A C     1 ? 
ATOM   2021 O O     . LEU A 1 281 ? 2.064   14.842  39.212 1.00 22.71  ? 260  LEU A O     1 ? 
ATOM   2022 C CB    . LEU A 1 281 ? 0.367   13.233  36.737 1.00 19.95  ? 260  LEU A CB    1 ? 
ATOM   2023 C CG    . LEU A 1 281 ? -0.365  13.570  35.445 1.00 18.69  ? 260  LEU A CG    1 ? 
ATOM   2024 C CD1   . LEU A 1 281 ? -1.505  12.612  35.248 1.00 18.72  ? 260  LEU A CD1   1 ? 
ATOM   2025 C CD2   . LEU A 1 281 ? -0.882  15.008  35.482 1.00 19.33  ? 260  LEU A CD2   1 ? 
ATOM   2026 N N     . LYS A 1 282 ? 2.561   12.658  38.896 1.00 18.95  ? 261  LYS A N     1 ? 
ATOM   2027 C CA    . LYS A 1 282 ? 2.910   12.431  40.287 1.00 17.80  ? 261  LYS A CA    1 ? 
ATOM   2028 C C     . LYS A 1 282 ? 4.092   13.309  40.712 1.00 19.97  ? 261  LYS A C     1 ? 
ATOM   2029 O O     . LYS A 1 282 ? 4.069   13.890  41.805 1.00 23.50  ? 261  LYS A O     1 ? 
ATOM   2030 C CB    . LYS A 1 282 ? 3.164   10.946  40.582 1.00 17.35  ? 261  LYS A CB    1 ? 
ATOM   2031 C CG    . LYS A 1 282 ? 1.955   10.047  40.465 1.00 18.52  ? 261  LYS A CG    1 ? 
ATOM   2032 C CD    . LYS A 1 282 ? 2.184   8.593   40.885 1.00 17.21  ? 261  LYS A CD    1 ? 
ATOM   2033 C CE    . LYS A 1 282 ? 0.959   7.754   40.763 1.00 16.74  ? 261  LYS A CE    1 ? 
ATOM   2034 N NZ    . LYS A 1 282 ? 1.129   6.367   41.232 1.00 17.19  ? 261  LYS A NZ    1 ? 
ATOM   2035 N N     . LEU A 1 283 ? 5.140   13.367  39.880 1.00 19.29  ? 262  LEU A N     1 ? 
ATOM   2036 C CA    . LEU A 1 283 ? 6.313   14.170  40.184 1.00 21.97  ? 262  LEU A CA    1 ? 
ATOM   2037 C C     . LEU A 1 283 ? 5.936   15.648  40.303 1.00 21.35  ? 262  LEU A C     1 ? 
ATOM   2038 O O     . LEU A 1 283 ? 6.620   16.397  40.983 1.00 20.62  ? 262  LEU A O     1 ? 
ATOM   2039 C CB    . LEU A 1 283 ? 7.358   13.977  39.088 1.00 22.26  ? 262  LEU A CB    1 ? 
ATOM   2040 C CG    . LEU A 1 283 ? 8.100   12.638  39.081 1.00 21.33  ? 262  LEU A CG    1 ? 
ATOM   2041 C CD1   . LEU A 1 283 ? 9.004   12.519  37.869 1.00 24.49  ? 262  LEU A CD1   1 ? 
ATOM   2042 C CD2   . LEU A 1 283 ? 8.887   12.455  40.364 1.00 23.00  ? 262  LEU A CD2   1 ? 
ATOM   2043 N N     . SER A 1 284 ? 4.870   16.047  39.612 1.00 20.65  ? 263  SER A N     1 ? 
ATOM   2044 C CA    . SER A 1 284 ? 4.448   17.429  39.519 1.00 22.56  ? 263  SER A CA    1 ? 
ATOM   2045 C C     . SER A 1 284 ? 3.479   17.830  40.627 1.00 23.26  ? 263  SER A C     1 ? 
ATOM   2046 O O     . SER A 1 284 ? 3.058   18.994  40.668 1.00 22.96  ? 263  SER A O     1 ? 
ATOM   2047 C CB    . SER A 1 284 ? 3.823   17.681  38.203 1.00 22.85  ? 263  SER A CB    1 ? 
ATOM   2048 O OG    . SER A 1 284 ? 4.659   17.365  37.101 1.00 21.97  ? 263  SER A OG    1 ? 
ATOM   2049 N N     . GLY A 1 285 ? 3.088   16.876  41.472 1.00 22.36  ? 264  GLY A N     1 ? 
ATOM   2050 C CA    . GLY A 1 285 ? 2.205   17.153  42.601 1.00 24.13  ? 264  GLY A CA    1 ? 
ATOM   2051 C C     . GLY A 1 285 ? 0.725   16.847  42.324 1.00 22.83  ? 264  GLY A C     1 ? 
ATOM   2052 O O     . GLY A 1 285 ? -0.169  17.335  43.036 1.00 23.69  ? 264  GLY A O     1 ? 
ATOM   2053 N N     . VAL A 1 286 ? 0.449   16.042  41.281 1.00 18.31  ? 265  VAL A N     1 ? 
ATOM   2054 C CA    . VAL A 1 286 ? -0.902  15.651  40.930 1.00 19.77  ? 265  VAL A CA    1 ? 
ATOM   2055 C C     . VAL A 1 286 ? -0.997  14.131  41.051 1.00 21.49  ? 265  VAL A C     1 ? 
ATOM   2056 O O     . VAL A 1 286 ? -0.471  13.397  40.211 1.00 18.48  ? 265  VAL A O     1 ? 
ATOM   2057 C CB    . VAL A 1 286 ? -1.310  16.122  39.523 1.00 20.82  ? 265  VAL A CB    1 ? 
ATOM   2058 C CG1   . VAL A 1 286 ? -2.721  15.682  39.182 1.00 22.79  ? 265  VAL A CG1   1 ? 
ATOM   2059 C CG2   . VAL A 1 286 ? -1.173  17.639  39.347 1.00 23.50  ? 265  VAL A CG2   1 ? 
ATOM   2060 N N     . GLY A 1 287 ? -1.655  13.646  42.108 1.00 21.26  ? 266  GLY A N     1 ? 
ATOM   2061 C CA    . GLY A 1 287 ? -1.737  12.213  42.295 1.00 22.34  ? 266  GLY A CA    1 ? 
ATOM   2062 C C     . GLY A 1 287 ? -2.248  11.849  43.680 1.00 24.22  ? 266  GLY A C     1 ? 
ATOM   2063 O O     . GLY A 1 287 ? -2.838  12.681  44.361 1.00 22.37  ? 266  GLY A O     1 ? 
ATOM   2064 N N     . PRO A 1 288 ? -2.127  10.558  44.055 1.00 22.60  ? 267  PRO A N     1 ? 
ATOM   2065 C CA    . PRO A 1 288 ? -2.616  10.068  45.331 1.00 23.69  ? 267  PRO A CA    1 ? 
ATOM   2066 C C     . PRO A 1 288 ? -1.821  10.711  46.463 1.00 21.39  ? 267  PRO A C     1 ? 
ATOM   2067 O O     . PRO A 1 288 ? -0.608  10.628  46.494 1.00 22.84  ? 267  PRO A O     1 ? 
ATOM   2068 C CB    . PRO A 1 288 ? -2.412  8.526   45.276 1.00 24.95  ? 267  PRO A CB    1 ? 
ATOM   2069 C CG    . PRO A 1 288 ? -2.120  8.226   43.804 1.00 23.77  ? 267  PRO A CG    1 ? 
ATOM   2070 C CD    . PRO A 1 288 ? -1.501  9.500   43.237 1.00 23.85  ? 267  PRO A CD    1 ? 
ATOM   2071 N N     . ARG A 1 289 ? -2.535  11.317  47.417 1.00 22.34  ? 268  ARG A N     1 ? 
ATOM   2072 C CA    . ARG A 1 289 ? -1.904  12.106  48.465 1.00 22.15  ? 268  ARG A CA    1 ? 
ATOM   2073 C C     . ARG A 1 289 ? -0.859  11.282  49.218 1.00 22.74  ? 268  ARG A C     1 ? 
ATOM   2074 O O     . ARG A 1 289 ? 0.253   11.753  49.447 1.00 24.50  ? 268  ARG A O     1 ? 
ATOM   2075 C CB    . ARG A 1 289 ? -2.984  12.614  49.424 1.00 23.75  ? 268  ARG A CB    1 ? 
ATOM   2076 C CG    . ARG A 1 289 ? -2.420  13.488  50.528 1.00 26.09  ? 268  ARG A CG    1 ? 
ATOM   2077 C CD    . ARG A 1 289 ? -3.499  14.048  51.470 1.00 27.59  ? 268  ARG A CD    1 ? 
ATOM   2078 N NE    . ARG A 1 289 ? -4.621  14.742  50.823 1.00 24.87  ? 268  ARG A NE    1 ? 
ATOM   2079 C CZ    . ARG A 1 289 ? -4.620  16.006  50.401 1.00 25.74  ? 268  ARG A CZ    1 ? 
ATOM   2080 N NH1   . ARG A 1 289 ? -3.531  16.765  50.418 1.00 23.25  ? 268  ARG A NH1   1 ? 
ATOM   2081 N NH2   . ARG A 1 289 ? -5.738  16.518  49.950 1.00 24.37  ? 268  ARG A NH2   1 ? 
ATOM   2082 N N     . GLU A 1 290 ? -1.222  10.067  49.624 1.00 23.58  ? 269  GLU A N     1 ? 
ATOM   2083 C CA    . GLU A 1 290 ? -0.344  9.243   50.453 1.00 27.52  ? 269  GLU A CA    1 ? 
ATOM   2084 C C     . GLU A 1 290 ? 0.997   8.980   49.766 1.00 26.53  ? 269  GLU A C     1 ? 
ATOM   2085 O O     . GLU A 1 290 ? 2.049   9.073   50.385 1.00 25.02  ? 269  GLU A O     1 ? 
ATOM   2086 C CB    . GLU A 1 290 ? -0.924  7.866   50.789 1.00 34.01  ? 269  GLU A CB    1 ? 
ATOM   2087 C CG    . GLU A 1 290 ? -2.160  7.923   51.677 1.00 47.92  ? 269  GLU A CG    1 ? 
ATOM   2088 C CD    . GLU A 1 290 ? -3.488  8.451   51.122 1.00 57.54  ? 269  GLU A CD    1 ? 
ATOM   2089 O OE1   . GLU A 1 290 ? -3.734  8.693   49.896 1.00 53.30  ? 269  GLU A OE1   1 ? 
ATOM   2090 O OE2   . GLU A 1 290 ? -4.329  8.620   52.033 1.00 65.80  ? 269  GLU A OE2   1 ? 
ATOM   2091 N N     . GLU A 1 291 ? 0.975   8.589   48.482 1.00 23.52  ? 270  GLU A N     1 ? 
ATOM   2092 C CA    . GLU A 1 291 ? 2.230   8.324   47.787 1.00 22.90  ? 270  GLU A CA    1 ? 
ATOM   2093 C C     . GLU A 1 291 ? 3.050   9.606   47.652 1.00 21.78  ? 270  GLU A C     1 ? 
ATOM   2094 O O     . GLU A 1 291 ? 4.257   9.593   47.878 1.00 20.41  ? 270  GLU A O     1 ? 
ATOM   2095 C CB    . GLU A 1 291 ? 1.946   7.739   46.409 1.00 24.75  ? 270  GLU A CB    1 ? 
ATOM   2096 C CG    . GLU A 1 291 ? 3.208   7.356   45.636 1.00 24.22  ? 270  GLU A CG    1 ? 
ATOM   2097 C CD    . GLU A 1 291 ? 2.859   6.819   44.249 1.00 24.00  ? 270  GLU A CD    1 ? 
ATOM   2098 O OE1   . GLU A 1 291 ? 3.807   6.369   43.584 1.00 24.09  ? 270  GLU A OE1   1 ? 
ATOM   2099 O OE2   . GLU A 1 291 ? 1.655   6.805   43.861 1.00 21.45  ? 270  GLU A OE2   1 ? 
ATOM   2100 N N     . LEU A 1 292 ? 2.423   10.718  47.254 1.00 22.02  ? 271  LEU A N     1 ? 
ATOM   2101 C CA    . LEU A 1 292 ? 3.177   11.944  47.056 1.00 23.84  ? 271  LEU A CA    1 ? 
ATOM   2102 C C     . LEU A 1 292 ? 3.814   12.382  48.373 1.00 22.57  ? 271  LEU A C     1 ? 
ATOM   2103 O O     . LEU A 1 292 ? 4.976   12.764  48.380 1.00 25.28  ? 271  LEU A O     1 ? 
ATOM   2104 C CB    . LEU A 1 292 ? 2.354   13.087  46.463 1.00 26.63  ? 271  LEU A CB    1 ? 
ATOM   2105 C CG    . LEU A 1 292 ? 1.586   12.827  45.163 1.00 30.77  ? 271  LEU A CG    1 ? 
ATOM   2106 C CD1   . LEU A 1 292 ? 1.309   14.073  44.339 1.00 26.47  ? 271  LEU A CD1   1 ? 
ATOM   2107 C CD2   . LEU A 1 292 ? 2.111   11.690  44.310 1.00 26.80  ? 271  LEU A CD2   1 ? 
ATOM   2108 N N     . GLU A 1 293 ? 3.045   12.342  49.475 1.00 25.97  ? 272  GLU A N     1 ? 
ATOM   2109 C CA    . GLU A 1 293 ? 3.555   12.767  50.778 1.00 26.09  ? 272  GLU A CA    1 ? 
ATOM   2110 C C     . GLU A 1 293 ? 4.707   11.869  51.220 1.00 25.92  ? 272  GLU A C     1 ? 
ATOM   2111 O O     . GLU A 1 293 ? 5.694   12.360  51.754 1.00 28.65  ? 272  GLU A O     1 ? 
ATOM   2112 C CB    . GLU A 1 293 ? 2.476   12.794  51.864 1.00 31.80  ? 272  GLU A CB    1 ? 
ATOM   2113 C CG    . GLU A 1 293 ? 1.317   13.716  51.517 1.00 38.74  ? 272  GLU A CG    1 ? 
ATOM   2114 C CD    . GLU A 1 293 ? 0.436   14.180  52.656 1.00 45.02  ? 272  GLU A CD    1 ? 
ATOM   2115 O OE1   . GLU A 1 293 ? -0.073  15.340  52.562 1.00 53.62  ? 272  GLU A OE1   1 ? 
ATOM   2116 O OE2   . GLU A 1 293 ? 0.346   13.425  53.655 1.00 57.75  ? 272  GLU A OE2   1 ? 
ATOM   2117 N N     . LYS A 1 294 ? 4.615   10.562  50.952 1.00 26.04  ? 273  LYS A N     1 ? 
ATOM   2118 C CA    . LYS A 1 294 ? 5.687   9.632   51.288 1.00 27.30  ? 273  LYS A CA    1 ? 
ATOM   2119 C C     . LYS A 1 294 ? 7.004   10.089  50.674 1.00 27.59  ? 273  LYS A C     1 ? 
ATOM   2120 O O     . LYS A 1 294 ? 8.060   9.951   51.290 1.00 29.20  ? 273  LYS A O     1 ? 
ATOM   2121 C CB    . LYS A 1 294 ? 5.394   8.228   50.745 1.00 32.16  ? 273  LYS A CB    1 ? 
ATOM   2122 C CG    . LYS A 1 294 ? 6.495   7.200   50.911 1.00 38.09  ? 273  LYS A CG    1 ? 
ATOM   2123 C CD    . LYS A 1 294 ? 6.372   6.006   49.963 1.00 46.35  ? 273  LYS A CD    1 ? 
ATOM   2124 C CE    . LYS A 1 294 ? 7.647   5.208   49.922 1.00 57.98  ? 273  LYS A CE    1 ? 
ATOM   2125 N NZ    . LYS A 1 294 ? 7.475   3.899   49.280 1.00 59.69  ? 273  LYS A NZ    1 ? 
ATOM   2126 N N     . PHE A 1 295 ? 6.938   10.615  49.443 1.00 25.41  ? 274  PHE A N     1 ? 
ATOM   2127 C CA    . PHE A 1 295 ? 8.121   11.089  48.752 1.00 25.76  ? 274  PHE A CA    1 ? 
ATOM   2128 C C     . PHE A 1 295 ? 8.422   12.559  49.023 1.00 25.60  ? 274  PHE A C     1 ? 
ATOM   2129 O O     . PHE A 1 295 ? 9.349   13.087  48.437 1.00 24.64  ? 274  PHE A O     1 ? 
ATOM   2130 C CB    . PHE A 1 295 ? 7.873   10.877  47.256 1.00 27.91  ? 274  PHE A CB    1 ? 
ATOM   2131 C CG    . PHE A 1 295 ? 8.072   9.430   46.833 1.00 27.19  ? 274  PHE A CG    1 ? 
ATOM   2132 C CD1   . PHE A 1 295 ? 9.320   8.826   46.943 1.00 28.08  ? 274  PHE A CD1   1 ? 
ATOM   2133 C CD2   . PHE A 1 295 ? 7.008   8.668   46.349 1.00 29.03  ? 274  PHE A CD2   1 ? 
ATOM   2134 C CE1   . PHE A 1 295 ? 9.498   7.500   46.580 1.00 28.31  ? 274  PHE A CE1   1 ? 
ATOM   2135 C CE2   . PHE A 1 295 ? 7.204   7.349   45.959 1.00 32.49  ? 274  PHE A CE2   1 ? 
ATOM   2136 C CZ    . PHE A 1 295 ? 8.447   6.765   46.085 1.00 29.04  ? 274  PHE A CZ    1 ? 
ATOM   2137 N N     . GLY A 1 296 ? 7.605   13.252  49.819 1.00 28.74  ? 275  GLY A N     1 ? 
ATOM   2138 C CA    . GLY A 1 296 ? 7.882   14.657  50.105 1.00 27.95  ? 275  GLY A CA    1 ? 
ATOM   2139 C C     . GLY A 1 296 ? 7.466   15.567  48.953 1.00 29.43  ? 275  GLY A C     1 ? 
ATOM   2140 O O     . GLY A 1 296 ? 7.937   16.701  48.858 1.00 30.10  ? 275  GLY A O     1 ? 
ATOM   2141 N N     . ILE A 1 297 ? 6.590   15.073  48.056 1.00 29.17  ? 276  ILE A N     1 ? 
ATOM   2142 C CA    . ILE A 1 297 ? 6.142   15.874  46.927 1.00 27.50  ? 276  ILE A CA    1 ? 
ATOM   2143 C C     . ILE A 1 297 ? 4.930   16.690  47.363 1.00 26.49  ? 276  ILE A C     1 ? 
ATOM   2144 O O     . ILE A 1 297 ? 3.904   16.127  47.751 1.00 23.75  ? 276  ILE A O     1 ? 
ATOM   2145 C CB    . ILE A 1 297 ? 5.802   15.003  45.701 1.00 27.99  ? 276  ILE A CB    1 ? 
ATOM   2146 C CG1   . ILE A 1 297 ? 7.008   14.172  45.200 1.00 26.36  ? 276  ILE A CG1   1 ? 
ATOM   2147 C CG2   . ILE A 1 297 ? 5.207   15.865  44.590 1.00 27.98  ? 276  ILE A CG2   1 ? 
ATOM   2148 C CD1   . ILE A 1 297 ? 6.610   12.955  44.395 1.00 26.85  ? 276  ILE A CD1   1 ? 
ATOM   2149 N N     . PRO A 1 298 ? 4.956   18.038  47.276 1.00 24.59  ? 277  PRO A N     1 ? 
ATOM   2150 C CA    . PRO A 1 298 ? 3.759   18.807  47.627 1.00 27.09  ? 277  PRO A CA    1 ? 
ATOM   2151 C C     . PRO A 1 298 ? 2.568   18.408  46.768 1.00 24.91  ? 277  PRO A C     1 ? 
ATOM   2152 O O     . PRO A 1 298 ? 2.664   18.332  45.540 1.00 26.32  ? 277  PRO A O     1 ? 
ATOM   2153 C CB    . PRO A 1 298 ? 4.189   20.274  47.472 1.00 28.27  ? 277  PRO A CB    1 ? 
ATOM   2154 C CG    . PRO A 1 298 ? 5.686   20.190  47.703 1.00 28.76  ? 277  PRO A CG    1 ? 
ATOM   2155 C CD    . PRO A 1 298 ? 6.101   18.901  46.965 1.00 27.15  ? 277  PRO A CD    1 ? 
ATOM   2156 N N     . VAL A 1 299 ? 1.437   18.134  47.444 1.00 23.89  ? 278  VAL A N     1 ? 
ATOM   2157 C CA    . VAL A 1 299 ? 0.213   17.785  46.750 1.00 20.60  ? 278  VAL A CA    1 ? 
ATOM   2158 C C     . VAL A 1 299 ? -0.561  19.041  46.321 1.00 22.25  ? 278  VAL A C     1 ? 
ATOM   2159 O O     . VAL A 1 299 ? -1.254  19.704  47.113 1.00 22.84  ? 278  VAL A O     1 ? 
ATOM   2160 C CB    . VAL A 1 299 ? -0.616  16.842  47.637 1.00 21.73  ? 278  VAL A CB    1 ? 
ATOM   2161 C CG1   . VAL A 1 299 ? -1.968  16.511  47.012 1.00 24.26  ? 278  VAL A CG1   1 ? 
ATOM   2162 C CG2   . VAL A 1 299 ? 0.175   15.570  47.945 1.00 20.91  ? 278  VAL A CG2   1 ? 
ATOM   2163 N N     . ILE A 1 300 ? -0.529  19.285  45.016 1.00 19.16  ? 279  ILE A N     1 ? 
ATOM   2164 C CA    . ILE A 1 300 ? -1.231  20.397  44.398 1.00 23.13  ? 279  ILE A CA    1 ? 
ATOM   2165 C C     . ILE A 1 300 ? -2.679  19.984  44.144 1.00 23.19  ? 279  ILE A C     1 ? 
ATOM   2166 O O     . ILE A 1 300 ? -3.588  20.795  44.229 1.00 20.41  ? 279  ILE A O     1 ? 
ATOM   2167 C CB    . ILE A 1 300 ? -0.505  20.844  43.120 1.00 25.75  ? 279  ILE A CB    1 ? 
ATOM   2168 C CG1   . ILE A 1 300 ? 0.914   21.285  43.419 1.00 29.37  ? 279  ILE A CG1   1 ? 
ATOM   2169 C CG2   . ILE A 1 300 ? -1.268  21.951  42.392 1.00 27.70  ? 279  ILE A CG2   1 ? 
ATOM   2170 C CD1   . ILE A 1 300 ? 1.732   21.629  42.186 1.00 32.77  ? 279  ILE A CD1   1 ? 
ATOM   2171 N N     . ALA A 1 301 ? -2.881  18.729  43.737 1.00 21.23  ? 280  ALA A N     1 ? 
ATOM   2172 C CA    . ALA A 1 301 ? -4.207  18.137  43.621 1.00 21.26  ? 280  ALA A CA    1 ? 
ATOM   2173 C C     . ALA A 1 301 ? -4.139  16.668  43.997 1.00 24.36  ? 280  ALA A C     1 ? 
ATOM   2174 O O     . ALA A 1 301 ? -3.356  15.912  43.431 1.00 22.45  ? 280  ALA A O     1 ? 
ATOM   2175 C CB    . ALA A 1 301 ? -4.768  18.300  42.245 1.00 22.90  ? 280  ALA A CB    1 ? 
ATOM   2176 N N     . ASN A 1 302 ? -4.986  16.290  44.958 1.00 25.08  ? 281  ASN A N     1 ? 
ATOM   2177 C CA    . ASN A 1 302 ? -5.145  14.908  45.368 1.00 23.17  ? 281  ASN A CA    1 ? 
ATOM   2178 C C     . ASN A 1 302 ? -6.009  14.240  44.310 1.00 24.96  ? 281  ASN A C     1 ? 
ATOM   2179 O O     . ASN A 1 302 ? -7.206  14.524  44.227 1.00 22.21  ? 281  ASN A O     1 ? 
ATOM   2180 C CB    . ASN A 1 302 ? -5.784  14.832  46.748 1.00 25.00  ? 281  ASN A CB    1 ? 
ATOM   2181 C CG    . ASN A 1 302 ? -6.095  13.418  47.194 1.00 30.74  ? 281  ASN A CG    1 ? 
ATOM   2182 O OD1   . ASN A 1 302 ? -5.358  12.460  46.902 1.00 29.32  ? 281  ASN A OD1   1 ? 
ATOM   2183 N ND2   . ASN A 1 302 ? -7.151  13.279  47.977 1.00 30.98  ? 281  ASN A ND2   1 ? 
ATOM   2184 N N     . VAL A 1 303 ? -5.387  13.396  43.473 1.00 22.81  ? 282  VAL A N     1 ? 
ATOM   2185 C CA    . VAL A 1 303 ? -6.112  12.684  42.431 1.00 21.87  ? 282  VAL A CA    1 ? 
ATOM   2186 C C     . VAL A 1 303 ? -5.786  11.198  42.581 1.00 22.77  ? 282  VAL A C     1 ? 
ATOM   2187 O O     . VAL A 1 303 ? -4.784  10.733  42.051 1.00 22.47  ? 282  VAL A O     1 ? 
ATOM   2188 C CB    . VAL A 1 303 ? -5.769  13.232  41.036 1.00 21.03  ? 282  VAL A CB    1 ? 
ATOM   2189 C CG1   . VAL A 1 303 ? -6.589  12.589  39.913 1.00 19.24  ? 282  VAL A CG1   1 ? 
ATOM   2190 C CG2   . VAL A 1 303 ? -5.951  14.740  40.977 1.00 24.91  ? 282  VAL A CG2   1 ? 
ATOM   2191 N N     . PRO A 1 304 ? -6.587  10.439  43.366 1.00 23.17  ? 283  PRO A N     1 ? 
ATOM   2192 C CA    . PRO A 1 304 ? -6.294  9.036   43.666 1.00 24.94  ? 283  PRO A CA    1 ? 
ATOM   2193 C C     . PRO A 1 304 ? -6.115  8.141   42.439 1.00 22.25  ? 283  PRO A C     1 ? 
ATOM   2194 O O     . PRO A 1 304 ? -5.444  7.124   42.519 1.00 22.19  ? 283  PRO A O     1 ? 
ATOM   2195 C CB    . PRO A 1 304 ? -7.530  8.562   44.468 1.00 27.74  ? 283  PRO A CB    1 ? 
ATOM   2196 C CG    . PRO A 1 304 ? -8.275  9.808   44.905 1.00 27.78  ? 283  PRO A CG    1 ? 
ATOM   2197 C CD    . PRO A 1 304 ? -7.805  10.931  44.034 1.00 24.12  ? 283  PRO A CD    1 ? 
ATOM   2198 N N     . GLY A 1 305 ? -6.776  8.503   41.340 1.00 21.41  ? 284  GLY A N     1 ? 
ATOM   2199 C CA    . GLY A 1 305 ? -6.823  7.677   40.133 1.00 21.67  ? 284  GLY A CA    1 ? 
ATOM   2200 C C     . GLY A 1 305 ? -5.520  7.649   39.338 1.00 19.37  ? 284  GLY A C     1 ? 
ATOM   2201 O O     . GLY A 1 305 ? -5.316  6.752   38.528 1.00 20.62  ? 284  GLY A O     1 ? 
ATOM   2202 N N     . VAL A 1 306 ? -4.620  8.614   39.574 1.00 21.41  ? 285  VAL A N     1 ? 
ATOM   2203 C CA    . VAL A 1 306 ? -3.384  8.733   38.811 1.00 19.27  ? 285  VAL A CA    1 ? 
ATOM   2204 C C     . VAL A 1 306 ? -2.516  7.510   39.121 1.00 18.31  ? 285  VAL A C     1 ? 
ATOM   2205 O O     . VAL A 1 306 ? -2.183  7.242   40.269 1.00 18.78  ? 285  VAL A O     1 ? 
ATOM   2206 C CB    . VAL A 1 306 ? -2.607  10.040  39.077 1.00 19.04  ? 285  VAL A CB    1 ? 
ATOM   2207 C CG1   . VAL A 1 306 ? -1.309  10.090  38.282 1.00 20.35  ? 285  VAL A CG1   1 ? 
ATOM   2208 C CG2   . VAL A 1 306 ? -3.446  11.277  38.784 1.00 18.48  ? 285  VAL A CG2   1 ? 
ATOM   2209 N N     . GLY A 1 307 ? -2.146  6.783   38.064 1.00 19.33  ? 286  GLY A N     1 ? 
ATOM   2210 C CA    . GLY A 1 307 ? -1.338  5.585   38.220 1.00 18.34  ? 286  GLY A CA    1 ? 
ATOM   2211 C C     . GLY A 1 307 ? -2.144  4.329   38.562 1.00 18.86  ? 286  GLY A C     1 ? 
ATOM   2212 O O     . GLY A 1 307 ? -1.583  3.222   38.516 1.00 19.58  ? 286  GLY A O     1 ? 
ATOM   2213 N N     . GLU A 1 308 ? -3.450  4.463   38.800 1.00 19.42  ? 287  GLU A N     1 ? 
ATOM   2214 C CA    . GLU A 1 308 ? -4.309  3.312   39.075 1.00 19.20  ? 287  GLU A CA    1 ? 
ATOM   2215 C C     . GLU A 1 308 ? -4.918  2.832   37.759 1.00 18.47  ? 287  GLU A C     1 ? 
ATOM   2216 O O     . GLU A 1 308 ? -4.767  3.464   36.714 1.00 19.11  ? 287  GLU A O     1 ? 
ATOM   2217 C CB    . GLU A 1 308 ? -5.436  3.676   40.047 1.00 19.16  ? 287  GLU A CB    1 ? 
ATOM   2218 C CG    . GLU A 1 308 ? -4.940  3.979   41.454 1.00 21.29  ? 287  GLU A CG    1 ? 
ATOM   2219 C CD    . GLU A 1 308 ? -4.150  2.852   42.100 1.00 23.69  ? 287  GLU A CD    1 ? 
ATOM   2220 O OE1   . GLU A 1 308 ? -2.989  3.064   42.524 1.00 24.35  ? 287  GLU A OE1   1 ? 
ATOM   2221 O OE2   . GLU A 1 308 ? -4.722  1.732   42.162 1.00 23.04  ? 287  GLU A OE2   1 ? 
ATOM   2222 N N     . ASN A 1 309 ? -5.613  1.695   37.819 1.00 17.98  ? 288  ASN A N     1 ? 
ATOM   2223 C CA    . ASN A 1 309 ? -6.373  1.196   36.688 1.00 17.03  ? 288  ASN A CA    1 ? 
ATOM   2224 C C     . ASN A 1 309 ? -5.475  0.794   35.514 1.00 16.72  ? 288  ASN A C     1 ? 
ATOM   2225 O O     . ASN A 1 309 ? -5.974  0.733   34.402 1.00 18.13  ? 288  ASN A O     1 ? 
ATOM   2226 C CB    . ASN A 1 309 ? -7.461  2.194   36.286 1.00 16.74  ? 288  ASN A CB    1 ? 
ATOM   2227 C CG    . ASN A 1 309 ? -8.313  1.688   35.146 1.00 19.49  ? 288  ASN A CG    1 ? 
ATOM   2228 O OD1   . ASN A 1 309 ? -8.963  0.639   35.263 1.00 18.66  ? 288  ASN A OD1   1 ? 
ATOM   2229 N ND2   . ASN A 1 309 ? -8.327  2.393   34.029 1.00 20.69  ? 288  ASN A ND2   1 ? 
ATOM   2230 N N     . LEU A 1 310 ? -4.192  0.470   35.761 1.00 18.12  ? 289  LEU A N     1 ? 
ATOM   2231 C CA    . LEU A 1 310 ? -3.318  0.015   34.694 1.00 19.25  ? 289  LEU A CA    1 ? 
ATOM   2232 C C     . LEU A 1 310 ? -3.856  -1.329  34.201 1.00 20.68  ? 289  LEU A C     1 ? 
ATOM   2233 O O     . LEU A 1 310 ? -4.029  -2.270  34.987 1.00 17.92  ? 289  LEU A O     1 ? 
ATOM   2234 C CB    . LEU A 1 310 ? -1.865  -0.119  35.132 1.00 19.60  ? 289  LEU A CB    1 ? 
ATOM   2235 C CG    . LEU A 1 310 ? -0.904  -0.738  34.108 1.00 18.74  ? 289  LEU A CG    1 ? 
ATOM   2236 C CD1   . LEU A 1 310 ? -0.777  0.162   32.868 1.00 19.33  ? 289  LEU A CD1   1 ? 
ATOM   2237 C CD2   . LEU A 1 310 ? 0.438   -1.027  34.733 1.00 18.86  ? 289  LEU A CD2   1 ? 
ATOM   2238 N N     . ASN A 1 311 ? -4.087  -1.422  32.898 1.00 19.56  ? 290  ASN A N     1 ? 
ATOM   2239 C CA    . ASN A 1 311 ? -4.422  -2.709  32.310 1.00 20.00  ? 290  ASN A CA    1 ? 
ATOM   2240 C C     . ASN A 1 311 ? -3.806  -2.864  30.919 1.00 19.49  ? 290  ASN A C     1 ? 
ATOM   2241 O O     . ASN A 1 311 ? -3.308  -1.910  30.296 1.00 17.83  ? 290  ASN A O     1 ? 
ATOM   2242 C CB    . ASN A 1 311 ? -5.912  -2.989  32.384 1.00 21.39  ? 290  ASN A CB    1 ? 
ATOM   2243 C CG    . ASN A 1 311 ? -6.795  -1.976  31.699 1.00 21.57  ? 290  ASN A CG    1 ? 
ATOM   2244 O OD1   . ASN A 1 311 ? -7.041  -0.862  32.211 1.00 25.50  ? 290  ASN A OD1   1 ? 
ATOM   2245 N ND2   . ASN A 1 311 ? -7.382  -2.417  30.612 1.00 17.40  ? 290  ASN A ND2   1 ? 
ATOM   2246 N N     . ASP A 1 312 ? -3.768  -4.126  30.506 1.00 16.89  ? 291  ASP A N     1 ? 
ATOM   2247 C CA    . ASP A 1 312 ? -2.998  -4.549  29.361 1.00 16.88  ? 291  ASP A CA    1 ? 
ATOM   2248 C C     . ASP A 1 312 ? -3.521  -5.929  28.951 1.00 18.70  ? 291  ASP A C     1 ? 
ATOM   2249 O O     . ASP A 1 312 ? -4.140  -6.634  29.756 1.00 20.22  ? 291  ASP A O     1 ? 
ATOM   2250 C CB    . ASP A 1 312 ? -1.519  -4.513  29.709 1.00 17.12  ? 291  ASP A CB    1 ? 
ATOM   2251 C CG    . ASP A 1 312 ? -0.545  -4.874  28.592 1.00 16.44  ? 291  ASP A CG    1 ? 
ATOM   2252 O OD1   . ASP A 1 312 ? -0.958  -4.783  27.416 1.00 15.58  ? 291  ASP A OD1   1 ? 
ATOM   2253 O OD2   . ASP A 1 312 ? 0.551   -5.362  28.942 1.00 18.72  ? 291  ASP A OD2   1 ? 
ATOM   2254 N N     . HIS A 1 313 ? -3.221  -6.309  27.714 1.00 18.07  ? 292  HIS A N     1 ? 
ATOM   2255 C CA    . HIS A 1 313 ? -3.529  -7.633  27.205 1.00 17.30  ? 292  HIS A CA    1 ? 
ATOM   2256 C C     . HIS A 1 313 ? -2.334  -8.566  27.404 1.00 18.16  ? 292  HIS A C     1 ? 
ATOM   2257 O O     . HIS A 1 313 ? -1.191  -8.119  27.345 1.00 16.80  ? 292  HIS A O     1 ? 
ATOM   2258 C CB    . HIS A 1 313 ? -3.752  -7.556  25.700 1.00 18.71  ? 292  HIS A CB    1 ? 
ATOM   2259 C CG    . HIS A 1 313 ? -5.075  -6.990  25.294 1.00 19.13  ? 292  HIS A CG    1 ? 
ATOM   2260 N ND1   . HIS A 1 313 ? -5.172  -6.056  24.299 1.00 18.11  ? 292  HIS A ND1   1 ? 
ATOM   2261 C CD2   . HIS A 1 313 ? -6.323  -7.266  25.662 1.00 20.68  ? 292  HIS A CD2   1 ? 
ATOM   2262 C CE1   . HIS A 1 313 ? -6.437  -5.756  24.109 1.00 19.47  ? 292  HIS A CE1   1 ? 
ATOM   2263 N NE2   . HIS A 1 313 ? -7.174  -6.495  24.910 1.00 19.72  ? 292  HIS A NE2   1 ? 
ATOM   2264 N N     . LEU A 1 314 ? -2.636  -9.855  27.599 1.00 16.81  ? 293  LEU A N     1 ? 
ATOM   2265 C CA    . LEU A 1 314 ? -1.685  -10.942 27.511 1.00 18.45  ? 293  LEU A CA    1 ? 
ATOM   2266 C C     . LEU A 1 314 ? -2.037  -11.842 26.327 1.00 19.06  ? 293  LEU A C     1 ? 
ATOM   2267 O O     . LEU A 1 314 ? -3.209  -12.024 25.992 1.00 19.82  ? 293  LEU A O     1 ? 
ATOM   2268 C CB    . LEU A 1 314 ? -1.724  -11.761 28.805 1.00 19.78  ? 293  LEU A CB    1 ? 
ATOM   2269 C CG    . LEU A 1 314 ? -1.020  -11.186 30.037 1.00 20.88  ? 293  LEU A CG    1 ? 
ATOM   2270 C CD1   . LEU A 1 314 ? -1.139  -12.169 31.217 1.00 20.22  ? 293  LEU A CD1   1 ? 
ATOM   2271 C CD2   . LEU A 1 314 ? 0.451   -10.851 29.805 1.00 20.10  ? 293  LEU A CD2   1 ? 
ATOM   2272 N N     . MET A 1 315 ? -0.986  -12.404 25.729 1.00 20.13  ? 294  MET A N     1 ? 
ATOM   2273 C CA    . MET A 1 315 ? -1.077  -13.327 24.615 1.00 20.96  ? 294  MET A CA    1 ? 
ATOM   2274 C C     . MET A 1 315 ? -0.389  -14.637 25.015 1.00 20.25  ? 294  MET A C     1 ? 
ATOM   2275 O O     . MET A 1 315 ? 0.586   -14.643 25.753 1.00 18.25  ? 294  MET A O     1 ? 
ATOM   2276 C CB    . MET A 1 315 ? -0.411  -12.798 23.340 1.00 21.32  ? 294  MET A CB    1 ? 
ATOM   2277 C CG    . MET A 1 315 ? 1.028   -12.379 23.470 1.00 22.84  ? 294  MET A CG    1 ? 
ATOM   2278 S SD    . MET A 1 315 ? 1.641   -11.735 21.899 1.00 25.59  ? 294  MET A SD    1 ? 
ATOM   2279 C CE    . MET A 1 315 ? 3.296   -11.270 22.424 1.00 29.69  ? 294  MET A CE    1 ? 
ATOM   2280 N N     . PHE A 1 316 ? -0.927  -15.742 24.510 1.00 17.95  ? 295  PHE A N     1 ? 
ATOM   2281 C CA    . PHE A 1 316 ? -0.349  -17.058 24.685 1.00 19.80  ? 295  PHE A CA    1 ? 
ATOM   2282 C C     . PHE A 1 316 ? -0.400  -17.745 23.331 1.00 21.23  ? 295  PHE A C     1 ? 
ATOM   2283 O O     . PHE A 1 316 ? -1.479  -17.816 22.734 1.00 22.43  ? 295  PHE A O     1 ? 
ATOM   2284 C CB    . PHE A 1 316 ? -1.173  -17.854 25.703 1.00 20.73  ? 295  PHE A CB    1 ? 
ATOM   2285 C CG    . PHE A 1 316 ? -0.667  -19.279 25.862 1.00 19.99  ? 295  PHE A CG    1 ? 
ATOM   2286 C CD1   . PHE A 1 316 ? 0.575   -19.512 26.446 1.00 21.02  ? 295  PHE A CD1   1 ? 
ATOM   2287 C CD2   . PHE A 1 316 ? -1.424  -20.367 25.442 1.00 22.96  ? 295  PHE A CD2   1 ? 
ATOM   2288 C CE1   . PHE A 1 316 ? 1.073   -20.797 26.571 1.00 24.35  ? 295  PHE A CE1   1 ? 
ATOM   2289 C CE2   . PHE A 1 316 ? -0.941  -21.660 25.602 1.00 26.79  ? 295  PHE A CE2   1 ? 
ATOM   2290 C CZ    . PHE A 1 316 ? 0.301   -21.877 26.167 1.00 27.43  ? 295  PHE A CZ    1 ? 
ATOM   2291 N N     . THR A 1 317 ? 0.755   -18.198 22.840 1.00 24.04  ? 296  THR A N     1 ? 
ATOM   2292 C CA    . THR A 1 317 ? 0.848   -18.718 21.486 1.00 22.20  ? 296  THR A CA    1 ? 
ATOM   2293 C C     . THR A 1 317 ? 0.773   -20.251 21.512 1.00 25.44  ? 296  THR A C     1 ? 
ATOM   2294 O O     . THR A 1 317 ? 1.604   -20.917 22.156 1.00 24.26  ? 296  THR A O     1 ? 
ATOM   2295 C CB    . THR A 1 317 ? 2.169   -18.278 20.861 1.00 23.65  ? 296  THR A CB    1 ? 
ATOM   2296 O OG1   . THR A 1 317 ? 2.124   -16.867 20.724 1.00 20.42  ? 296  THR A OG1   1 ? 
ATOM   2297 C CG2   . THR A 1 317 ? 2.337   -18.876 19.467 1.00 23.02  ? 296  THR A CG2   1 ? 
ATOM   2298 N N     . LEU A 1 318 ? -0.179  -20.790 20.730 1.00 25.99  ? 297  LEU A N     1 ? 
ATOM   2299 C CA    . LEU A 1 318 ? -0.240  -22.202 20.394 1.00 25.93  ? 297  LEU A CA    1 ? 
ATOM   2300 C C     . LEU A 1 318 ? 0.574   -22.450 19.123 1.00 26.99  ? 297  LEU A C     1 ? 
ATOM   2301 O O     . LEU A 1 318 ? 0.361   -21.796 18.112 1.00 25.02  ? 297  LEU A O     1 ? 
ATOM   2302 C CB    . LEU A 1 318 ? -1.685  -22.654 20.190 1.00 28.63  ? 297  LEU A CB    1 ? 
ATOM   2303 C CG    . LEU A 1 318 ? -2.737  -22.128 21.171 1.00 32.81  ? 297  LEU A CG    1 ? 
ATOM   2304 C CD1   . LEU A 1 318 ? -4.106  -22.734 20.921 1.00 33.80  ? 297  LEU A CD1   1 ? 
ATOM   2305 C CD2   . LEU A 1 318 ? -2.291  -22.342 22.589 1.00 34.65  ? 297  LEU A CD2   1 ? 
ATOM   2306 N N     . LYS A 1 319 ? 1.498   -23.422 19.179 1.00 24.50  ? 298  LYS A N     1 ? 
ATOM   2307 C CA    . LYS A 1 319 ? 2.439   -23.698 18.114 1.00 25.00  ? 298  LYS A CA    1 ? 
ATOM   2308 C C     . LYS A 1 319 ? 2.191   -25.102 17.549 1.00 26.34  ? 298  LYS A C     1 ? 
ATOM   2309 O O     . LYS A 1 319 ? 1.870   -26.007 18.297 1.00 23.37  ? 298  LYS A O     1 ? 
ATOM   2310 C CB    . LYS A 1 319 ? 3.846   -23.569 18.683 1.00 25.40  ? 298  LYS A CB    1 ? 
ATOM   2311 C CG    . LYS A 1 319 ? 4.157   -22.145 19.151 1.00 27.23  ? 298  LYS A CG    1 ? 
ATOM   2312 C CD    . LYS A 1 319 ? 5.543   -22.035 19.762 1.00 28.60  ? 298  LYS A CD    1 ? 
ATOM   2313 C CE    . LYS A 1 319 ? 5.759   -20.696 20.411 1.00 29.28  ? 298  LYS A CE    1 ? 
ATOM   2314 N NZ    . LYS A 1 319 ? 7.101   -20.714 20.986 1.00 31.81  ? 298  LYS A NZ    1 ? 
ATOM   2315 N N     . PHE A 1 320 ? 2.296   -25.233 16.220 1.00 26.72  ? 299  PHE A N     1 ? 
ATOM   2316 C CA    . PHE A 1 320 ? 1.974   -26.478 15.525 1.00 30.31  ? 299  PHE A CA    1 ? 
ATOM   2317 C C     . PHE A 1 320 ? 3.020   -26.738 14.455 1.00 26.98  ? 299  PHE A C     1 ? 
ATOM   2318 O O     . PHE A 1 320 ? 3.264   -25.877 13.614 1.00 31.04  ? 299  PHE A O     1 ? 
ATOM   2319 C CB    . PHE A 1 320 ? 0.598   -26.421 14.865 1.00 27.05  ? 299  PHE A CB    1 ? 
ATOM   2320 C CG    . PHE A 1 320 ? -0.505  -26.090 15.844 1.00 27.87  ? 299  PHE A CG    1 ? 
ATOM   2321 C CD1   . PHE A 1 320 ? -0.949  -27.033 16.765 1.00 28.17  ? 299  PHE A CD1   1 ? 
ATOM   2322 C CD2   . PHE A 1 320 ? -1.039  -24.804 15.892 1.00 27.74  ? 299  PHE A CD2   1 ? 
ATOM   2323 C CE1   . PHE A 1 320 ? -1.925  -26.703 17.693 1.00 30.52  ? 299  PHE A CE1   1 ? 
ATOM   2324 C CE2   . PHE A 1 320 ? -1.994  -24.475 16.829 1.00 29.84  ? 299  PHE A CE2   1 ? 
ATOM   2325 C CZ    . PHE A 1 320 ? -2.451  -25.428 17.716 1.00 31.45  ? 299  PHE A CZ    1 ? 
ATOM   2326 N N     . VAL A 1 321 ? 3.669   -27.909 14.523 1.00 31.63  ? 300  VAL A N     1 ? 
ATOM   2327 C CA    . VAL A 1 321 ? 4.645   -28.310 13.513 1.00 30.29  ? 300  VAL A CA    1 ? 
ATOM   2328 C C     . VAL A 1 321 ? 3.913   -29.173 12.487 1.00 28.83  ? 300  VAL A C     1 ? 
ATOM   2329 O O     . VAL A 1 321 ? 3.027   -29.930 12.857 1.00 32.17  ? 300  VAL A O     1 ? 
ATOM   2330 C CB    . VAL A 1 321 ? 5.865   -29.047 14.110 1.00 34.83  ? 300  VAL A CB    1 ? 
ATOM   2331 C CG1   . VAL A 1 321 ? 6.814   -29.569 13.023 1.00 34.27  ? 300  VAL A CG1   1 ? 
ATOM   2332 C CG2   . VAL A 1 321 ? 6.617   -28.174 15.116 1.00 32.97  ? 300  VAL A CG2   1 ? 
ATOM   2333 N N     . SER A 1 322 ? 4.274   -29.021 11.213 1.00 30.88  ? 301  SER A N     1 ? 
ATOM   2334 C CA    . SER A 1 322 ? 3.611   -29.704 10.107 1.00 35.26  ? 301  SER A CA    1 ? 
ATOM   2335 C C     . SER A 1 322 ? 4.561   -30.718 9.472  1.00 32.66  ? 301  SER A C     1 ? 
ATOM   2336 O O     . SER A 1 322 ? 5.738   -30.415 9.281  1.00 38.29  ? 301  SER A O     1 ? 
ATOM   2337 C CB    . SER A 1 322 ? 3.157   -28.712 9.053  1.00 36.25  ? 301  SER A CB    1 ? 
ATOM   2338 O OG    . SER A 1 322 ? 2.570   -29.371 7.932  1.00 38.63  ? 301  SER A OG    1 ? 
ATOM   2339 N N     . GLU A 1 323 ? 4.040   -31.889 9.095  1.00 37.96  ? 302  GLU A N     1 ? 
ATOM   2340 C CA    . GLU A 1 323 ? 4.746   -32.776 8.177  1.00 41.83  ? 302  GLU A CA    1 ? 
ATOM   2341 C C     . GLU A 1 323 ? 4.640   -32.269 6.737  1.00 40.22  ? 302  GLU A C     1 ? 
ATOM   2342 O O     . GLU A 1 323 ? 5.522   -32.534 5.924  1.00 42.03  ? 302  GLU A O     1 ? 
ATOM   2343 C CB    . GLU A 1 323 ? 4.187   -34.192 8.127  1.00 51.45  ? 302  GLU A CB    1 ? 
ATOM   2344 C CG    . GLU A 1 323 ? 4.061   -34.855 9.494  1.00 57.30  ? 302  GLU A CG    1 ? 
ATOM   2345 C CD    . GLU A 1 323 ? 3.681   -36.322 9.396  1.00 61.60  ? 302  GLU A CD    1 ? 
ATOM   2346 O OE1   . GLU A 1 323 ? 4.482   -37.165 9.851  1.00 64.98  ? 302  GLU A OE1   1 ? 
ATOM   2347 O OE2   . GLU A 1 323 ? 2.593   -36.634 8.868  1.00 67.72  ? 302  GLU A OE2   1 ? 
ATOM   2348 N N     . LYS A 1 324 ? 3.551   -31.557 6.411  1.00 39.44  ? 303  LYS A N     1 ? 
ATOM   2349 C CA    . LYS A 1 324 ? 3.306   -31.121 5.042  1.00 38.36  ? 303  LYS A CA    1 ? 
ATOM   2350 C C     . LYS A 1 324 ? 3.987   -29.769 4.794  1.00 38.73  ? 303  LYS A C     1 ? 
ATOM   2351 O O     . LYS A 1 324 ? 3.945   -28.865 5.642  1.00 34.03  ? 303  LYS A O     1 ? 
ATOM   2352 C CB    . LYS A 1 324 ? 1.790   -31.158 4.808  1.00 42.79  ? 303  LYS A CB    1 ? 
ATOM   2353 C CG    . LYS A 1 324 ? 1.325   -30.558 3.482  1.00 48.22  ? 303  LYS A CG    1 ? 
ATOM   2354 C CD    . LYS A 1 324 ? -0.180  -30.583 3.248  1.00 56.77  ? 303  LYS A CD    1 ? 
ATOM   2355 C CE    . LYS A 1 324 ? -0.722  -31.971 3.195  1.00 65.82  ? 303  LYS A CE    1 ? 
ATOM   2356 N NZ    . LYS A 1 324 ? -2.092  -31.988 2.676  1.00 71.98  ? 303  LYS A NZ    1 ? 
ATOM   2357 N N     . ASN A 1 325 ? 4.642   -29.640 3.637  1.00 32.27  ? 304  ASN A N     1 ? 
ATOM   2358 C CA    . ASN A 1 325 ? 5.324   -28.409 3.269  1.00 38.12  ? 304  ASN A CA    1 ? 
ATOM   2359 C C     . ASN A 1 325 ? 4.306   -27.272 3.227  1.00 39.67  ? 304  ASN A C     1 ? 
ATOM   2360 O O     . ASN A 1 325 ? 3.177   -27.460 2.785  1.00 37.57  ? 304  ASN A O     1 ? 
ATOM   2361 C CB    . ASN A 1 325 ? 6.056   -28.493 1.931  1.00 38.20  ? 304  ASN A CB    1 ? 
ATOM   2362 C CG    . ASN A 1 325 ? 6.954   -27.293 1.703  1.00 40.49  ? 304  ASN A CG    1 ? 
ATOM   2363 O OD1   . ASN A 1 325 ? 7.845   -27.014 2.508  1.00 49.09  ? 304  ASN A OD1   1 ? 
ATOM   2364 N ND2   . ASN A 1 325 ? 6.780   -26.567 0.610  1.00 43.88  ? 304  ASN A ND2   1 ? 
ATOM   2365 N N     . ILE A 1 326 ? 4.706   -26.106 3.745  1.00 39.05  ? 305  ILE A N     1 ? 
ATOM   2366 C CA    . ILE A 1 326 ? 3.957   -24.880 3.545  1.00 35.20  ? 305  ILE A CA    1 ? 
ATOM   2367 C C     . ILE A 1 326 ? 4.845   -23.999 2.676  1.00 39.01  ? 305  ILE A C     1 ? 
ATOM   2368 O O     . ILE A 1 326 ? 5.927   -23.587 3.089  1.00 31.68  ? 305  ILE A O     1 ? 
ATOM   2369 C CB    . ILE A 1 326 ? 3.563   -24.240 4.900  1.00 37.36  ? 305  ILE A CB    1 ? 
ATOM   2370 C CG1   . ILE A 1 326 ? 2.636   -25.146 5.712  1.00 33.96  ? 305  ILE A CG1   1 ? 
ATOM   2371 C CG2   . ILE A 1 326 ? 2.944   -22.858 4.698  1.00 39.43  ? 305  ILE A CG2   1 ? 
ATOM   2372 C CD1   . ILE A 1 326 ? 2.434   -24.721 7.157  1.00 37.92  ? 305  ILE A CD1   1 ? 
ATOM   2373 N N     . GLU A 1 327 ? 4.376   -23.746 1.445  1.00 41.28  ? 306  GLU A N     1 ? 
ATOM   2374 C CA    . GLU A 1 327 ? 5.213   -23.207 0.391  1.00 39.21  ? 306  GLU A CA    1 ? 
ATOM   2375 C C     . GLU A 1 327 ? 5.661   -21.785 0.710  1.00 39.36  ? 306  GLU A C     1 ? 
ATOM   2376 O O     . GLU A 1 327 ? 4.842   -20.928 1.015  1.00 45.41  ? 306  GLU A O     1 ? 
ATOM   2377 C CB    . GLU A 1 327 ? 4.334   -23.199 -0.858 1.00 47.11  ? 306  GLU A CB    1 ? 
ATOM   2378 C CG    . GLU A 1 327 ? 4.941   -22.527 -2.079 1.00 50.32  ? 306  GLU A CG    1 ? 
ATOM   2379 C CD    . GLU A 1 327 ? 4.065   -22.803 -3.290 1.00 48.63  ? 306  GLU A CD    1 ? 
ATOM   2380 O OE1   . GLU A 1 327 ? 4.579   -22.941 -4.410 1.00 52.78  ? 306  GLU A OE1   1 ? 
ATOM   2381 O OE2   . GLU A 1 327 ? 2.857   -22.940 -3.090 1.00 51.57  ? 306  GLU A OE2   1 ? 
ATOM   2382 N N     . ASP A 1 328 ? 6.969   -21.557 0.583  1.00 36.14  ? 307  ASP A N     1 ? 
ATOM   2383 C CA    . ASP A 1 328 ? 7.586   -20.246 0.743  1.00 43.19  ? 307  ASP A CA    1 ? 
ATOM   2384 C C     . ASP A 1 328 ? 7.281   -19.667 2.127  1.00 39.73  ? 307  ASP A C     1 ? 
ATOM   2385 O O     . ASP A 1 328 ? 7.210   -18.458 2.264  1.00 39.16  ? 307  ASP A O     1 ? 
ATOM   2386 C CB    . ASP A 1 328 ? 7.181   -19.304 -0.382 1.00 46.40  ? 307  ASP A CB    1 ? 
ATOM   2387 C CG    . ASP A 1 328 ? 7.552   -19.793 -1.783 1.00 50.62  ? 307  ASP A CG    1 ? 
ATOM   2388 O OD1   . ASP A 1 328 ? 8.668   -20.327 -1.932 1.00 44.90  ? 307  ASP A OD1   1 ? 
ATOM   2389 O OD2   . ASP A 1 328 ? 6.724   -19.640 -2.707 1.00 44.36  ? 307  ASP A OD2   1 ? 
ATOM   2390 N N     . SER A 1 329 ? 7.194   -20.529 3.150  1.00 38.88  ? 308  SER A N     1 ? 
ATOM   2391 C CA    . SER A 1 329 ? 6.923   -20.104 4.516  1.00 37.30  ? 308  SER A CA    1 ? 
ATOM   2392 C C     . SER A 1 329 ? 8.205   -19.853 5.305  1.00 43.22  ? 308  SER A C     1 ? 
ATOM   2393 O O     . SER A 1 329 ? 8.174   -19.132 6.303  1.00 41.29  ? 308  SER A O     1 ? 
ATOM   2394 C CB    . SER A 1 329 ? 6.044   -21.099 5.223  1.00 33.70  ? 308  SER A CB    1 ? 
ATOM   2395 O OG    . SER A 1 329 ? 6.666   -22.370 5.306  1.00 32.72  ? 308  SER A OG    1 ? 
ATOM   2396 N N     . ILE A 1 330 ? 9.323   -20.428 4.843  1.00 43.30  ? 309  ILE A N     1 ? 
ATOM   2397 C CA    . ILE A 1 330 ? 10.584  -20.436 5.565  1.00 41.54  ? 309  ILE A CA    1 ? 
ATOM   2398 C C     . ILE A 1 330 ? 11.511  -19.433 4.895  1.00 44.38  ? 309  ILE A C     1 ? 
ATOM   2399 O O     . ILE A 1 330 ? 11.925  -19.652 3.771  1.00 42.20  ? 309  ILE A O     1 ? 
ATOM   2400 C CB    . ILE A 1 330 ? 11.216  -21.845 5.561  1.00 44.47  ? 309  ILE A CB    1 ? 
ATOM   2401 C CG1   . ILE A 1 330 ? 10.244  -22.939 6.038  1.00 44.31  ? 309  ILE A CG1   1 ? 
ATOM   2402 C CG2   . ILE A 1 330 ? 12.516  -21.863 6.366  1.00 47.46  ? 309  ILE A CG2   1 ? 
ATOM   2403 C CD1   . ILE A 1 330 ? 9.748   -22.756 7.460  1.00 42.77  ? 309  ILE A CD1   1 ? 
ATOM   2404 N N     . PHE A 1 331 ? 11.832  -18.334 5.582  1.00 43.06  ? 310  PHE A N     1 ? 
ATOM   2405 C CA    . PHE A 1 331 ? 12.726  -17.321 5.033  1.00 46.07  ? 310  PHE A CA    1 ? 
ATOM   2406 C C     . PHE A 1 331 ? 13.344  -16.555 6.194  1.00 45.68  ? 310  PHE A C     1 ? 
ATOM   2407 O O     . PHE A 1 331 ? 12.909  -16.692 7.335  1.00 45.45  ? 310  PHE A O     1 ? 
ATOM   2408 C CB    . PHE A 1 331 ? 11.993  -16.373 4.080  1.00 45.80  ? 310  PHE A CB    1 ? 
ATOM   2409 C CG    . PHE A 1 331 ? 10.837  -15.683 4.776  1.00 51.17  ? 310  PHE A CG    1 ? 
ATOM   2410 C CD1   . PHE A 1 331 ? 11.036  -14.500 5.471  1.00 52.91  ? 310  PHE A CD1   1 ? 
ATOM   2411 C CD2   . PHE A 1 331 ? 9.575   -16.254 4.798  1.00 58.75  ? 310  PHE A CD2   1 ? 
ATOM   2412 C CE1   . PHE A 1 331 ? 9.988   -13.891 6.142  1.00 57.80  ? 310  PHE A CE1   1 ? 
ATOM   2413 C CE2   . PHE A 1 331 ? 8.535   -15.639 5.473  1.00 56.78  ? 310  PHE A CE2   1 ? 
ATOM   2414 C CZ    . PHE A 1 331 ? 8.743   -14.463 6.144  1.00 55.83  ? 310  PHE A CZ    1 ? 
ATOM   2415 N N     . ASN A 1 332 ? 14.350  -15.739 5.887  1.00 44.44  ? 311  ASN A N     1 ? 
ATOM   2416 C CA    . ASN A 1 332 ? 15.073  -15.001 6.903  1.00 45.40  ? 311  ASN A CA    1 ? 
ATOM   2417 C C     . ASN A 1 332 ? 14.950  -13.513 6.587  1.00 46.83  ? 311  ASN A C     1 ? 
ATOM   2418 O O     . ASN A 1 332 ? 15.656  -13.008 5.719  1.00 42.07  ? 311  ASN A O     1 ? 
ATOM   2419 C CB    . ASN A 1 332 ? 16.528  -15.446 6.990  1.00 44.97  ? 311  ASN A CB    1 ? 
ATOM   2420 C CG    . ASN A 1 332 ? 17.294  -14.666 8.031  1.00 52.23  ? 311  ASN A CG    1 ? 
ATOM   2421 O OD1   . ASN A 1 332 ? 16.699  -14.007 8.892  1.00 52.10  ? 311  ASN A OD1   1 ? 
ATOM   2422 N ND2   . ASN A 1 332 ? 18.611  -14.735 7.978  1.00 56.19  ? 311  ASN A ND2   1 ? 
ATOM   2423 N N     . PRO A 1 333 ? 14.035  -12.767 7.258  1.00 40.31  ? 312  PRO A N     1 ? 
ATOM   2424 C CA    . PRO A 1 333 ? 13.869  -11.341 6.980  1.00 39.93  ? 312  PRO A CA    1 ? 
ATOM   2425 C C     . PRO A 1 333 ? 15.004  -10.463 7.506  1.00 40.54  ? 312  PRO A C     1 ? 
ATOM   2426 O O     . PRO A 1 333 ? 15.071  -9.280  7.163  1.00 44.58  ? 312  PRO A O     1 ? 
ATOM   2427 C CB    . PRO A 1 333 ? 12.516  -11.008 7.657  1.00 44.80  ? 312  PRO A CB    1 ? 
ATOM   2428 C CG    . PRO A 1 333 ? 12.362  -12.031 8.763  1.00 39.78  ? 312  PRO A CG    1 ? 
ATOM   2429 C CD    . PRO A 1 333 ? 13.132  -13.266 8.303  1.00 38.60  ? 312  PRO A CD    1 ? 
ATOM   2430 N N     . LEU A 1 334 ? 15.917  -11.060 8.296  1.00 44.79  ? 313  LEU A N     1 ? 
ATOM   2431 C CA    . LEU A 1 334 ? 17.020  -10.333 8.916  1.00 50.54  ? 313  LEU A CA    1 ? 
ATOM   2432 C C     . LEU A 1 334 ? 18.354  -10.438 8.160  1.00 58.75  ? 313  LEU A C     1 ? 
ATOM   2433 O O     . LEU A 1 334 ? 19.314  -9.781  8.545  1.00 56.64  ? 313  LEU A O     1 ? 
ATOM   2434 C CB    . LEU A 1 334 ? 17.128  -10.853 10.347 1.00 45.17  ? 313  LEU A CB    1 ? 
ATOM   2435 C CG    . LEU A 1 334 ? 15.807  -10.833 11.126 1.00 44.93  ? 313  LEU A CG    1 ? 
ATOM   2436 C CD1   . LEU A 1 334 ? 15.906  -11.334 12.548 1.00 46.25  ? 313  LEU A CD1   1 ? 
ATOM   2437 C CD2   . LEU A 1 334 ? 15.239  -9.417  11.086 1.00 43.72  ? 313  LEU A CD2   1 ? 
ATOM   2438 N N     . SER A 1 335 ? 18.419  -11.221 7.080  1.00 59.05  ? 314  SER A N     1 ? 
ATOM   2439 C CA    . SER A 1 335 ? 19.658  -11.396 6.328  1.00 62.67  ? 314  SER A CA    1 ? 
ATOM   2440 C C     . SER A 1 335 ? 20.043  -10.118 5.575  1.00 66.98  ? 314  SER A C     1 ? 
ATOM   2441 O O     . SER A 1 335 ? 19.192  -9.335  5.161  1.00 53.94  ? 314  SER A O     1 ? 
ATOM   2442 C CB    . SER A 1 335 ? 19.541  -12.551 5.365  1.00 58.26  ? 314  SER A CB    1 ? 
ATOM   2443 O OG    . SER A 1 335 ? 18.803  -12.168 4.212  1.00 52.65  ? 314  SER A OG    1 ? 
ATOM   2444 N N     . ASP A 1 336 ? 21.350  -9.949  5.344  1.00 69.75  ? 315  ASP A N     1 ? 
ATOM   2445 C CA    . ASP A 1 336 ? 21.883  -8.757  4.702  1.00 66.10  ? 315  ASP A CA    1 ? 
ATOM   2446 C C     . ASP A 1 336 ? 21.315  -8.635  3.286  1.00 64.54  ? 315  ASP A C     1 ? 
ATOM   2447 O O     . ASP A 1 336 ? 21.056  -7.528  2.815  1.00 67.81  ? 315  ASP A O     1 ? 
ATOM   2448 C CB    . ASP A 1 336 ? 23.404  -8.742  4.790  1.00 73.17  ? 315  ASP A CB    1 ? 
ATOM   2449 C CG    . ASP A 1 336 ? 23.967  -8.550  6.194  1.00 75.15  ? 315  ASP A CG    1 ? 
ATOM   2450 O OD1   . ASP A 1 336 ? 23.497  -7.625  6.875  1.00 78.69  ? 315  ASP A OD1   1 ? 
ATOM   2451 O OD2   . ASP A 1 336 ? 24.871  -9.315  6.599  1.00 85.04  ? 315  ASP A OD2   1 ? 
ATOM   2452 N N     . GLU A 1 337 ? 21.076  -9.776  2.630  1.00 61.11  ? 316  GLU A N     1 ? 
ATOM   2453 C CA    . GLU A 1 337 ? 20.525  -9.791  1.282  1.00 66.95  ? 316  GLU A CA    1 ? 
ATOM   2454 C C     . GLU A 1 337 ? 19.066  -9.331  1.277  1.00 66.84  ? 316  GLU A C     1 ? 
ATOM   2455 O O     . GLU A 1 337 ? 18.633  -8.595  0.383  1.00 64.14  ? 316  GLU A O     1 ? 
ATOM   2456 C CB    . GLU A 1 337 ? 20.473  -11.185 0.655  1.00 70.45  ? 316  GLU A CB    1 ? 
ATOM   2457 C CG    . GLU A 1 337 ? 21.461  -12.204 1.210  1.00 67.86  ? 316  GLU A CG    1 ? 
ATOM   2458 C CD    . GLU A 1 337 ? 21.358  -13.433 0.331  1.00 67.75  ? 316  GLU A CD    1 ? 
ATOM   2459 O OE1   . GLU A 1 337 ? 21.938  -13.398 -0.771 1.00 71.35  ? 316  GLU A OE1   1 ? 
ATOM   2460 O OE2   . GLU A 1 337 ? 20.613  -14.362 0.700  1.00 68.26  ? 316  GLU A OE2   1 ? 
ATOM   2461 N N     . ALA A 1 338 ? 18.299  -9.816  2.262  1.00 64.20  ? 317  ALA A N     1 ? 
ATOM   2462 C CA    . ALA A 1 338 ? 16.916  -9.402  2.421  1.00 59.54  ? 317  ALA A CA    1 ? 
ATOM   2463 C C     . ALA A 1 338 ? 16.846  -7.893  2.654  1.00 52.27  ? 317  ALA A C     1 ? 
ATOM   2464 O O     . ALA A 1 338 ? 16.132  -7.177  1.950  1.00 50.71  ? 317  ALA A O     1 ? 
ATOM   2465 C CB    . ALA A 1 338 ? 16.291  -10.177 3.562  1.00 58.11  ? 317  ALA A CB    1 ? 
ATOM   2466 N N     . ILE A 1 339 ? 17.604  -7.420  3.645  1.00 51.77  ? 318  ILE A N     1 ? 
ATOM   2467 C CA    . ILE A 1 339 ? 17.559  -6.025  4.042  1.00 57.30  ? 318  ILE A CA    1 ? 
ATOM   2468 C C     . ILE A 1 339 ? 17.992  -5.150  2.864  1.00 59.49  ? 318  ILE A C     1 ? 
ATOM   2469 O O     . ILE A 1 339 ? 17.313  -4.180  2.534  1.00 54.23  ? 318  ILE A O     1 ? 
ATOM   2470 C CB    . ILE A 1 339 ? 18.373  -5.825  5.335  1.00 56.53  ? 318  ILE A CB    1 ? 
ATOM   2471 C CG1   . ILE A 1 339 ? 17.669  -6.502  6.511  1.00 54.12  ? 318  ILE A CG1   1 ? 
ATOM   2472 C CG2   . ILE A 1 339 ? 18.634  -4.344  5.607  1.00 63.40  ? 318  ILE A CG2   1 ? 
ATOM   2473 C CD1   . ILE A 1 339 ? 18.407  -6.427  7.834  1.00 58.94  ? 318  ILE A CD1   1 ? 
ATOM   2474 N N     . ASP A 1 340 ? 19.062  -5.540  2.158  1.00 63.55  ? 319  ASP A N     1 ? 
ATOM   2475 C CA    . ASP A 1 340 ? 19.494  -4.799  0.981  1.00 60.33  ? 319  ASP A CA    1 ? 
ATOM   2476 C C     . ASP A 1 340 ? 18.390  -4.763  -0.070 1.00 59.63  ? 319  ASP A C     1 ? 
ATOM   2477 O O     . ASP A 1 340 ? 18.072  -3.705  -0.610 1.00 59.27  ? 319  ASP A O     1 ? 
ATOM   2478 C CB    . ASP A 1 340 ? 20.784  -5.354  0.412  1.00 70.38  ? 319  ASP A CB    1 ? 
ATOM   2479 C CG    . ASP A 1 340 ? 22.009  -5.039  1.254  1.00 73.35  ? 319  ASP A CG    1 ? 
ATOM   2480 O OD1   . ASP A 1 340 ? 21.879  -4.275  2.236  1.00 74.64  ? 319  ASP A OD1   1 ? 
ATOM   2481 O OD2   . ASP A 1 340 ? 23.078  -5.586  0.939  1.00 84.65  ? 319  ASP A OD2   1 ? 
ATOM   2482 N N     . GLN A 1 341 ? 17.785  -5.917  -0.352 1.00 54.56  ? 320  GLN A N     1 ? 
ATOM   2483 C CA    . GLN A 1 341 ? 16.722  -5.956  -1.339 1.00 60.25  ? 320  GLN A CA    1 ? 
ATOM   2484 C C     . GLN A 1 341 ? 15.635  -4.948  -0.948 1.00 63.59  ? 320  GLN A C     1 ? 
ATOM   2485 O O     . GLN A 1 341 ? 15.034  -4.298  -1.810 1.00 52.71  ? 320  GLN A O     1 ? 
ATOM   2486 C CB    . GLN A 1 341 ? 16.172  -7.371  -1.508 1.00 65.25  ? 320  GLN A CB    1 ? 
ATOM   2487 C CG    . GLN A 1 341 ? 15.477  -7.592  -2.851 1.00 78.32  ? 320  GLN A CG    1 ? 
ATOM   2488 C CD    . GLN A 1 341 ? 14.831  -8.958  -2.981 1.00 86.83  ? 320  GLN A CD    1 ? 
ATOM   2489 O OE1   . GLN A 1 341 ? 15.409  -9.987  -2.607 1.00 87.25  ? 320  GLN A OE1   1 ? 
ATOM   2490 N NE2   . GLN A 1 341 ? 13.608  -8.985  -3.493 1.00 89.75  ? 320  GLN A NE2   1 ? 
ATOM   2491 N N     . TRP A 1 342 ? 15.387  -4.825  0.367  1.00 59.04  ? 321  TRP A N     1 ? 
ATOM   2492 C CA    . TRP A 1 342 ? 14.361  -3.924  0.875  1.00 50.33  ? 321  TRP A CA    1 ? 
ATOM   2493 C C     . TRP A 1 342 ? 14.778  -2.471  0.644  1.00 45.85  ? 321  TRP A C     1 ? 
ATOM   2494 O O     . TRP A 1 342 ? 13.989  -1.690  0.121  1.00 49.26  ? 321  TRP A O     1 ? 
ATOM   2495 C CB    . TRP A 1 342 ? 14.034  -4.200  2.358  1.00 44.79  ? 321  TRP A CB    1 ? 
ATOM   2496 C CG    . TRP A 1 342 ? 12.926  -3.316  2.857  1.00 36.93  ? 321  TRP A CG    1 ? 
ATOM   2497 C CD1   . TRP A 1 342 ? 11.587  -3.545  2.773  1.00 38.91  ? 321  TRP A CD1   1 ? 
ATOM   2498 C CD2   . TRP A 1 342 ? 13.073  -1.998  3.411  1.00 35.02  ? 321  TRP A CD2   1 ? 
ATOM   2499 N NE1   . TRP A 1 342 ? 10.893  -2.472  3.257  1.00 36.18  ? 321  TRP A NE1   1 ? 
ATOM   2500 C CE2   . TRP A 1 342 ? 11.778  -1.510  3.661  1.00 35.93  ? 321  TRP A CE2   1 ? 
ATOM   2501 C CE3   . TRP A 1 342 ? 14.166  -1.195  3.735  1.00 35.63  ? 321  TRP A CE3   1 ? 
ATOM   2502 C CZ2   . TRP A 1 342 ? 11.551  -0.250  4.208  1.00 34.79  ? 321  TRP A CZ2   1 ? 
ATOM   2503 C CZ3   . TRP A 1 342 ? 13.934  0.052   4.284  1.00 34.92  ? 321  TRP A CZ3   1 ? 
ATOM   2504 C CH2   . TRP A 1 342 ? 12.647  0.521   4.500  1.00 30.76  ? 321  TRP A CH2   1 ? 
ATOM   2505 N N     . TYR A 1 343 ? 16.005  -2.107  1.037  1.00 45.68  ? 322  TYR A N     1 ? 
ATOM   2506 C CA    . TYR A 1 343 ? 16.489  -0.757  0.798  1.00 56.54  ? 322  TYR A CA    1 ? 
ATOM   2507 C C     . TYR A 1 343 ? 16.371  -0.427  -0.687 1.00 59.50  ? 322  TYR A C     1 ? 
ATOM   2508 O O     . TYR A 1 343 ? 15.869  0.640   -1.035 1.00 60.09  ? 322  TYR A O     1 ? 
ATOM   2509 C CB    . TYR A 1 343 ? 17.921  -0.524  1.293  1.00 57.27  ? 322  TYR A CB    1 ? 
ATOM   2510 C CG    . TYR A 1 343 ? 18.000  -0.293  2.796  1.00 59.89  ? 322  TYR A CG    1 ? 
ATOM   2511 C CD1   . TYR A 1 343 ? 17.625  0.926   3.365  1.00 62.89  ? 322  TYR A CD1   1 ? 
ATOM   2512 C CD2   . TYR A 1 343 ? 18.455  -1.289  3.650  1.00 59.06  ? 322  TYR A CD2   1 ? 
ATOM   2513 C CE1   . TYR A 1 343 ? 17.700  1.138   4.735  1.00 61.40  ? 322  TYR A CE1   1 ? 
ATOM   2514 C CE2   . TYR A 1 343 ? 18.525  -1.092  5.018  1.00 57.02  ? 322  TYR A CE2   1 ? 
ATOM   2515 C CZ    . TYR A 1 343 ? 18.146  0.121   5.562  1.00 61.05  ? 322  TYR A CZ    1 ? 
ATOM   2516 O OH    . TYR A 1 343 ? 18.229  0.255   6.919  1.00 65.26  ? 322  TYR A OH    1 ? 
ATOM   2517 N N     . LYS A 1 344 ? 16.790  -1.367  -1.545 1.00 67.41  ? 323  LYS A N     1 ? 
ATOM   2518 C CA    . LYS A 1 344 ? 16.909  -1.118  -2.971 1.00 67.83  ? 323  LYS A CA    1 ? 
ATOM   2519 C C     . LYS A 1 344 ? 15.551  -0.856  -3.609 1.00 67.03  ? 323  LYS A C     1 ? 
ATOM   2520 O O     . LYS A 1 344 ? 15.378  0.192   -4.220 1.00 74.80  ? 323  LYS A O     1 ? 
ATOM   2521 C CB    . LYS A 1 344 ? 17.633  -2.258  -3.690 1.00 74.71  ? 323  LYS A CB    1 ? 
ATOM   2522 C CG    . LYS A 1 344 ? 19.142  -2.182  -3.527 1.00 80.95  ? 323  LYS A CG    1 ? 
ATOM   2523 C CD    . LYS A 1 344 ? 19.933  -2.744  -4.704 1.00 82.99  ? 323  LYS A CD    1 ? 
ATOM   2524 C CE    . LYS A 1 344 ? 21.232  -2.032  -4.878 1.00 81.97  ? 323  LYS A CE    1 ? 
ATOM   2525 N NZ    . LYS A 1 344 ? 21.876  -2.475  -6.113 1.00 90.05  ? 323  LYS A NZ    1 ? 
ATOM   2526 N N     . ASN A 1 345 ? 14.602  -1.794  -3.490 1.00 67.01  ? 324  ASN A N     1 ? 
ATOM   2527 C CA    . ASN A 1 345 ? 13.326  -1.624  -4.170 1.00 68.77  ? 324  ASN A CA    1 ? 
ATOM   2528 C C     . ASN A 1 345 ? 12.130  -2.048  -3.313 1.00 70.21  ? 324  ASN A C     1 ? 
ATOM   2529 O O     . ASN A 1 345 ? 11.043  -2.274  -3.860 1.00 70.25  ? 324  ASN A O     1 ? 
ATOM   2530 C CB    . ASN A 1 345 ? 13.309  -2.361  -5.507 1.00 78.92  ? 324  ASN A CB    1 ? 
ATOM   2531 C CG    . ASN A 1 345 ? 13.444  -3.858  -5.351 1.00 83.32  ? 324  ASN A CG    1 ? 
ATOM   2532 O OD1   . ASN A 1 345 ? 13.974  -4.350  -4.347 1.00 88.55  ? 324  ASN A OD1   1 ? 
ATOM   2533 N ND2   . ASN A 1 345 ? 12.987  -4.597  -6.350 1.00 91.63  ? 324  ASN A ND2   1 ? 
ATOM   2534 N N     . LYS A 1 346 ? 12.310  -2.132  -1.982 1.00 57.23  ? 325  LYS A N     1 ? 
ATOM   2535 C CA    . LYS A 1 346 ? 11.202  -2.355  -1.065 1.00 46.53  ? 325  LYS A CA    1 ? 
ATOM   2536 C C     . LYS A 1 346 ? 10.469  -3.657  -1.369 1.00 44.67  ? 325  LYS A C     1 ? 
ATOM   2537 O O     . LYS A 1 346 ? 9.243   -3.713  -1.295 1.00 43.84  ? 325  LYS A O     1 ? 
ATOM   2538 C CB    . LYS A 1 346 ? 10.206  -1.191  -1.098 1.00 48.42  ? 325  LYS A CB    1 ? 
ATOM   2539 C CG    . LYS A 1 346 ? 10.807  0.199   -0.817 1.00 51.20  ? 325  LYS A CG    1 ? 
ATOM   2540 C CD    . LYS A 1 346 ? 11.112  0.417   0.655  1.00 45.65  ? 325  LYS A CD    1 ? 
ATOM   2541 C CE    . LYS A 1 346 ? 11.909  1.636   0.907  1.00 50.50  ? 325  LYS A CE    1 ? 
ATOM   2542 N NZ    . LYS A 1 346 ? 13.316  1.359   0.615  1.00 54.32  ? 325  LYS A NZ    1 ? 
ATOM   2543 N N     . THR A 1 347 ? 11.229  -4.711  -1.685 1.00 48.96  ? 326  THR A N     1 ? 
ATOM   2544 C CA    . THR A 1 347 ? 10.679  -6.050  -1.858 1.00 49.17  ? 326  THR A CA    1 ? 
ATOM   2545 C C     . THR A 1 347 ? 11.607  -7.052  -1.182 1.00 43.08  ? 326  THR A C     1 ? 
ATOM   2546 O O     . THR A 1 347 ? 12.711  -6.718  -0.749 1.00 45.88  ? 326  THR A O     1 ? 
ATOM   2547 C CB    . THR A 1 347 ? 10.498  -6.404  -3.342 1.00 55.06  ? 326  THR A CB    1 ? 
ATOM   2548 O OG1   . THR A 1 347 ? 11.758  -6.207  -3.985 1.00 51.98  ? 326  THR A OG1   1 ? 
ATOM   2549 C CG2   . THR A 1 347 ? 9.411   -5.578  -4.009 1.00 54.89  ? 326  THR A CG2   1 ? 
ATOM   2550 N N     . GLY A 1 348 ? 11.140  -8.299  -1.111 1.00 43.23  ? 327  GLY A N     1 ? 
ATOM   2551 C CA    . GLY A 1 348 ? 11.960  -9.401  -0.648 1.00 45.04  ? 327  GLY A CA    1 ? 
ATOM   2552 C C     . GLY A 1 348 ? 11.524  -9.873  0.736  1.00 46.18  ? 327  GLY A C     1 ? 
ATOM   2553 O O     . GLY A 1 348 ? 10.500  -9.435  1.243  1.00 44.52  ? 327  GLY A O     1 ? 
ATOM   2554 N N     . PRO A 1 349 ? 12.291  -10.796 1.357  1.00 45.20  ? 328  PRO A N     1 ? 
ATOM   2555 C CA    . PRO A 1 349 ? 11.913  -11.387 2.646  1.00 45.29  ? 328  PRO A CA    1 ? 
ATOM   2556 C C     . PRO A 1 349 ? 11.669  -10.433 3.826  1.00 39.82  ? 328  PRO A C     1 ? 
ATOM   2557 O O     . PRO A 1 349 ? 10.878  -10.730 4.714  1.00 37.13  ? 328  PRO A O     1 ? 
ATOM   2558 C CB    . PRO A 1 349 ? 13.097  -12.337 2.911  1.00 43.98  ? 328  PRO A CB    1 ? 
ATOM   2559 C CG    . PRO A 1 349 ? 13.599  -12.685 1.526  1.00 49.53  ? 328  PRO A CG    1 ? 
ATOM   2560 C CD    . PRO A 1 349 ? 13.536  -11.348 0.805  1.00 47.52  ? 328  PRO A CD    1 ? 
ATOM   2561 N N     . SER A 1 350 ? 12.345  -9.283  3.827  1.00 39.85  ? 329  SER A N     1 ? 
ATOM   2562 C CA    . SER A 1 350 ? 12.226  -8.302  4.896  1.00 40.58  ? 329  SER A CA    1 ? 
ATOM   2563 C C     . SER A 1 350 ? 10.850  -7.632  4.883  1.00 38.61  ? 329  SER A C     1 ? 
ATOM   2564 O O     . SER A 1 350 ? 10.509  -6.899  5.811  1.00 31.29  ? 329  SER A O     1 ? 
ATOM   2565 C CB    . SER A 1 350 ? 13.329  -7.275  4.793  1.00 37.62  ? 329  SER A CB    1 ? 
ATOM   2566 O OG    . SER A 1 350 ? 14.608  -7.852  5.012  1.00 37.68  ? 329  SER A OG    1 ? 
ATOM   2567 N N     . SER A 1 351 ? 10.058  -7.875  3.826  1.00 38.28  ? 330  SER A N     1 ? 
ATOM   2568 C CA    . SER A 1 351 ? 8.715   -7.323  3.707  1.00 37.61  ? 330  SER A CA    1 ? 
ATOM   2569 C C     . SER A 1 351 ? 7.746   -8.072  4.621  1.00 32.74  ? 330  SER A C     1 ? 
ATOM   2570 O O     . SER A 1 351 ? 6.647   -7.610  4.858  1.00 38.99  ? 330  SER A O     1 ? 
ATOM   2571 C CB    . SER A 1 351 ? 8.217   -7.393  2.282  1.00 44.93  ? 330  SER A CB    1 ? 
ATOM   2572 O OG    . SER A 1 351 ? 9.211   -6.958  1.369  1.00 46.88  ? 330  SER A OG    1 ? 
ATOM   2573 N N     . TYR A 1 352 ? 8.128   -9.263  5.085  1.00 34.46  ? 331  TYR A N     1 ? 
ATOM   2574 C CA    . TYR A 1 352 ? 7.171   -10.203 5.636  1.00 32.80  ? 331  TYR A CA    1 ? 
ATOM   2575 C C     . TYR A 1 352 ? 7.302   -10.258 7.150  1.00 34.06  ? 331  TYR A C     1 ? 
ATOM   2576 O O     . TYR A 1 352 ? 8.383   -10.562 7.659  1.00 31.36  ? 331  TYR A O     1 ? 
ATOM   2577 C CB    . TYR A 1 352 ? 7.460   -11.566 5.009  1.00 38.23  ? 331  TYR A CB    1 ? 
ATOM   2578 C CG    . TYR A 1 352 ? 7.323   -11.596 3.494  1.00 42.02  ? 331  TYR A CG    1 ? 
ATOM   2579 C CD1   . TYR A 1 352 ? 6.279   -10.947 2.847  1.00 38.32  ? 331  TYR A CD1   1 ? 
ATOM   2580 C CD2   . TYR A 1 352 ? 8.252   -12.277 2.712  1.00 44.79  ? 331  TYR A CD2   1 ? 
ATOM   2581 C CE1   . TYR A 1 352 ? 6.157   -10.979 1.466  1.00 41.41  ? 331  TYR A CE1   1 ? 
ATOM   2582 C CE2   . TYR A 1 352 ? 8.140   -12.313 1.332  1.00 42.98  ? 331  TYR A CE2   1 ? 
ATOM   2583 C CZ    . TYR A 1 352 ? 7.098   -11.656 0.712  1.00 40.74  ? 331  TYR A CZ    1 ? 
ATOM   2584 O OH    . TYR A 1 352 ? 6.994   -11.707 -0.635 1.00 45.88  ? 331  TYR A OH    1 ? 
ATOM   2585 N N     . TYR A 1 353 ? 6.200   -9.923  7.842  1.00 31.63  ? 332  TYR A N     1 ? 
ATOM   2586 C CA    . TYR A 1 353 ? 6.049   -10.242 9.249  1.00 29.36  ? 332  TYR A CA    1 ? 
ATOM   2587 C C     . TYR A 1 353 ? 5.133   -11.457 9.366  1.00 26.56  ? 332  TYR A C     1 ? 
ATOM   2588 O O     . TYR A 1 353 ? 4.062   -11.447 8.787  1.00 27.15  ? 332  TYR A O     1 ? 
ATOM   2589 C CB    . TYR A 1 353 ? 5.515   -9.011  9.993  1.00 29.07  ? 332  TYR A CB    1 ? 
ATOM   2590 C CG    . TYR A 1 353 ? 5.541   -9.231  11.501 1.00 26.10  ? 332  TYR A CG    1 ? 
ATOM   2591 C CD1   . TYR A 1 353 ? 6.714   -9.077  12.226 1.00 30.52  ? 332  TYR A CD1   1 ? 
ATOM   2592 C CD2   . TYR A 1 353 ? 4.417   -9.668  12.173 1.00 26.28  ? 332  TYR A CD2   1 ? 
ATOM   2593 C CE1   . TYR A 1 353 ? 6.758   -9.301  13.590 1.00 30.50  ? 332  TYR A CE1   1 ? 
ATOM   2594 C CE2   . TYR A 1 353 ? 4.450   -9.931  13.532 1.00 27.88  ? 332  TYR A CE2   1 ? 
ATOM   2595 C CZ    . TYR A 1 353 ? 5.616   -9.722  14.241 1.00 29.78  ? 332  TYR A CZ    1 ? 
ATOM   2596 O OH    . TYR A 1 353 ? 5.626   -9.959  15.571 1.00 33.59  ? 332  TYR A OH    1 ? 
ATOM   2597 N N     . PRO A 1 354 ? 5.500   -12.535 10.101 1.00 29.19  ? 333  PRO A N     1 ? 
ATOM   2598 C CA    . PRO A 1 354 ? 4.696   -13.765 10.156 1.00 32.93  ? 333  PRO A CA    1 ? 
ATOM   2599 C C     . PRO A 1 354 ? 3.253   -13.641 10.642 1.00 30.74  ? 333  PRO A C     1 ? 
ATOM   2600 O O     . PRO A 1 354 ? 2.396   -14.394 10.191 1.00 31.82  ? 333  PRO A O     1 ? 
ATOM   2601 C CB    . PRO A 1 354 ? 5.488   -14.721 11.088 1.00 34.26  ? 333  PRO A CB    1 ? 
ATOM   2602 C CG    . PRO A 1 354 ? 6.870   -14.135 11.157 1.00 36.84  ? 333  PRO A CG    1 ? 
ATOM   2603 C CD    . PRO A 1 354 ? 6.736   -12.650 10.884 1.00 33.04  ? 333  PRO A CD    1 ? 
ATOM   2604 N N     . GLY A 1 355 ? 2.998   -12.752 11.613 1.00 29.11  ? 334  GLY A N     1 ? 
ATOM   2605 C CA    . GLY A 1 355 ? 1.642   -12.491 12.089 1.00 29.40  ? 334  GLY A CA    1 ? 
ATOM   2606 C C     . GLY A 1 355 ? 0.868   -11.665 11.055 1.00 27.77  ? 334  GLY A C     1 ? 
ATOM   2607 O O     . GLY A 1 355 ? 1.068   -10.458 10.962 1.00 27.72  ? 334  GLY A O     1 ? 
ATOM   2608 N N     . VAL A 1 356 ? -0.028  -12.318 10.301 1.00 27.03  ? 335  VAL A N     1 ? 
ATOM   2609 C CA    . VAL A 1 356 ? -0.610  -11.733 9.094  1.00 28.81  ? 335  VAL A CA    1 ? 
ATOM   2610 C C     . VAL A 1 356 ? -2.127  -11.628 9.192  1.00 27.24  ? 335  VAL A C     1 ? 
ATOM   2611 O O     . VAL A 1 356 ? -2.722  -10.781 8.533  1.00 27.69  ? 335  VAL A O     1 ? 
ATOM   2612 C CB    . VAL A 1 356 ? -0.198  -12.544 7.838  1.00 31.36  ? 335  VAL A CB    1 ? 
ATOM   2613 C CG1   . VAL A 1 356 ? -0.667  -13.988 7.903  1.00 29.10  ? 335  VAL A CG1   1 ? 
ATOM   2614 C CG2   . VAL A 1 356 ? -0.744  -11.955 6.550  1.00 39.09  ? 335  VAL A CG2   1 ? 
ATOM   2615 N N     . ALA A 1 357 ? -2.774  -12.549 9.914  1.00 24.44  ? 336  ALA A N     1 ? 
ATOM   2616 C CA    . ALA A 1 357 ? -4.219  -12.560 10.015 1.00 26.48  ? 336  ALA A CA    1 ? 
ATOM   2617 C C     . ALA A 1 357 ? -4.690  -12.520 11.468 1.00 26.78  ? 336  ALA A C     1 ? 
ATOM   2618 O O     . ALA A 1 357 ? -4.077  -13.096 12.360 1.00 23.63  ? 336  ALA A O     1 ? 
ATOM   2619 C CB    . ALA A 1 357 ? -4.764  -13.781 9.326  1.00 27.02  ? 336  ALA A CB    1 ? 
ATOM   2620 N N     . SER A 1 358 ? -5.859  -11.923 11.676 1.00 27.01  ? 337  SER A N     1 ? 
ATOM   2621 C CA    . SER A 1 358 ? -6.481  -11.924 12.985 1.00 25.77  ? 337  SER A CA    1 ? 
ATOM   2622 C C     . SER A 1 358 ? -7.967  -12.242 12.849 1.00 23.97  ? 337  SER A C     1 ? 
ATOM   2623 O O     . SER A 1 358 ? -8.640  -11.718 11.958 1.00 25.56  ? 337  SER A O     1 ? 
ATOM   2624 C CB    . SER A 1 358 ? -6.264  -10.568 13.655 1.00 27.90  ? 337  SER A CB    1 ? 
ATOM   2625 O OG    . SER A 1 358 ? -7.074  -10.462 14.815 1.00 33.20  ? 337  SER A OG    1 ? 
ATOM   2626 N N     . GLY A 1 359 ? -8.476  -13.060 13.779 1.00 22.88  ? 338  GLY A N     1 ? 
ATOM   2627 C CA    . GLY A 1 359 ? -9.892  -13.321 13.898 1.00 26.75  ? 338  GLY A CA    1 ? 
ATOM   2628 C C     . GLY A 1 359 ? -10.413 -13.086 15.308 1.00 27.96  ? 338  GLY A C     1 ? 
ATOM   2629 O O     . GLY A 1 359 ? -9.704  -13.331 16.285 1.00 32.29  ? 338  GLY A O     1 ? 
ATOM   2630 N N     . PHE A 1 360 ? -11.663 -12.612 15.389 1.00 25.35  ? 339  PHE A N     1 ? 
ATOM   2631 C CA    . PHE A 1 360 ? -12.332 -12.390 16.659 1.00 24.23  ? 339  PHE A CA    1 ? 
ATOM   2632 C C     . PHE A 1 360 ? -13.449 -13.408 16.856 1.00 27.29  ? 339  PHE A C     1 ? 
ATOM   2633 O O     . PHE A 1 360 ? -14.211 -13.652 15.916 1.00 25.98  ? 339  PHE A O     1 ? 
ATOM   2634 C CB    . PHE A 1 360 ? -12.819 -10.947 16.630 1.00 23.74  ? 339  PHE A CB    1 ? 
ATOM   2635 C CG    . PHE A 1 360 ? -11.619 -10.011 16.695 1.00 23.09  ? 339  PHE A CG    1 ? 
ATOM   2636 C CD1   . PHE A 1 360 ? -10.905 -9.686  15.549 1.00 25.48  ? 339  PHE A CD1   1 ? 
ATOM   2637 C CD2   . PHE A 1 360 ? -11.168 -9.533  17.921 1.00 23.56  ? 339  PHE A CD2   1 ? 
ATOM   2638 C CE1   . PHE A 1 360 ? -9.814  -8.845  15.615 1.00 25.36  ? 339  PHE A CE1   1 ? 
ATOM   2639 C CE2   . PHE A 1 360 ? -10.075 -8.681  17.980 1.00 24.63  ? 339  PHE A CE2   1 ? 
ATOM   2640 C CZ    . PHE A 1 360 ? -9.397  -8.364  16.842 1.00 25.57  ? 339  PHE A CZ    1 ? 
ATOM   2641 N N     . VAL A 1 361 ? -13.562 -13.930 18.088 1.00 24.18  ? 340  VAL A N     1 ? 
ATOM   2642 C CA    . VAL A 1 361 ? -14.495 -15.007 18.397 1.00 29.25  ? 340  VAL A CA    1 ? 
ATOM   2643 C C     . VAL A 1 361 ? -15.303 -14.716 19.658 1.00 33.32  ? 340  VAL A C     1 ? 
ATOM   2644 O O     . VAL A 1 361 ? -14.961 -13.872 20.490 1.00 30.89  ? 340  VAL A O     1 ? 
ATOM   2645 C CB    . VAL A 1 361 ? -13.771 -16.349 18.553 1.00 29.22  ? 340  VAL A CB    1 ? 
ATOM   2646 C CG1   . VAL A 1 361 ? -12.939 -16.666 17.327 1.00 28.73  ? 340  VAL A CG1   1 ? 
ATOM   2647 C CG2   . VAL A 1 361 ? -12.923 -16.404 19.826 1.00 30.06  ? 340  VAL A CG2   1 ? 
ATOM   2648 N N     . SER A 1 362 ? -16.406 -15.463 19.784 1.00 36.49  ? 341  SER A N     1 ? 
ATOM   2649 C CA    . SER A 1 362 ? -17.246 -15.465 20.965 1.00 39.60  ? 341  SER A CA    1 ? 
ATOM   2650 C C     . SER A 1 362 ? -17.256 -16.886 21.506 1.00 41.48  ? 341  SER A C     1 ? 
ATOM   2651 O O     . SER A 1 362 ? -18.076 -17.684 21.076 1.00 46.03  ? 341  SER A O     1 ? 
ATOM   2652 C CB    . SER A 1 362 ? -18.653 -14.959 20.636 1.00 43.54  ? 341  SER A CB    1 ? 
ATOM   2653 O OG    . SER A 1 362 ? -19.534 -15.052 21.749 1.00 46.29  ? 341  SER A OG    1 ? 
ATOM   2654 N N     . SER A 1 363 ? -16.339 -17.198 22.432 1.00 41.15  ? 342  SER A N     1 ? 
ATOM   2655 C CA    . SER A 1 363 ? -16.061 -18.581 22.787 1.00 42.25  ? 342  SER A CA    1 ? 
ATOM   2656 C C     . SER A 1 363 ? -17.251 -19.256 23.471 1.00 50.00  ? 342  SER A C     1 ? 
ATOM   2657 O O     . SER A 1 363 ? -17.255 -20.476 23.587 1.00 59.06  ? 342  SER A O     1 ? 
ATOM   2658 C CB    . SER A 1 363 ? -14.835 -18.690 23.645 1.00 39.10  ? 342  SER A CB    1 ? 
ATOM   2659 O OG    . SER A 1 363 ? -15.080 -18.189 24.945 1.00 34.56  ? 342  SER A OG    1 ? 
ATOM   2660 N N     . ASP A 1 364 ? -18.239 -18.470 23.922 1.00 52.37  ? 343  ASP A N     1 ? 
ATOM   2661 C CA    . ASP A 1 364 ? -19.415 -18.978 24.612 1.00 56.46  ? 343  ASP A CA    1 ? 
ATOM   2662 C C     . ASP A 1 364 ? -20.678 -18.770 23.773 1.00 66.40  ? 343  ASP A C     1 ? 
ATOM   2663 O O     . ASP A 1 364 ? -21.784 -18.967 24.269 1.00 71.70  ? 343  ASP A O     1 ? 
ATOM   2664 C CB    . ASP A 1 364 ? -19.594 -18.284 25.952 1.00 57.89  ? 343  ASP A CB    1 ? 
ATOM   2665 C CG    . ASP A 1 364 ? -19.948 -16.806 25.886 1.00 56.37  ? 343  ASP A CG    1 ? 
ATOM   2666 O OD1   . ASP A 1 364 ? -20.212 -16.310 24.776 1.00 61.57  ? 343  ASP A OD1   1 ? 
ATOM   2667 O OD2   . ASP A 1 364 ? -19.936 -16.154 26.943 1.00 61.40  ? 343  ASP A OD2   1 ? 
ATOM   2668 N N     . GLY A 1 365 ? -20.522 -18.305 22.527 1.00 64.78  ? 344  GLY A N     1 ? 
ATOM   2669 C CA    . GLY A 1 365 ? -21.609 -18.301 21.564 1.00 60.24  ? 344  GLY A CA    1 ? 
ATOM   2670 C C     . GLY A 1 365 ? -22.552 -17.104 21.698 1.00 59.46  ? 344  GLY A C     1 ? 
ATOM   2671 O O     . GLY A 1 365 ? -23.367 -16.893 20.807 1.00 70.22  ? 344  GLY A O     1 ? 
ATOM   2672 N N     . THR A 1 366 ? -22.430 -16.300 22.765 1.00 60.08  ? 345  THR A N     1 ? 
ATOM   2673 C CA    . THR A 1 366 ? -23.436 -15.288 23.072 1.00 58.52  ? 345  THR A CA    1 ? 
ATOM   2674 C C     . THR A 1 366 ? -23.316 -14.086 22.138 1.00 57.61  ? 345  THR A C     1 ? 
ATOM   2675 O O     . THR A 1 366 ? -24.235 -13.278 22.062 1.00 55.37  ? 345  THR A O     1 ? 
ATOM   2676 C CB    . THR A 1 366 ? -23.366 -14.824 24.529 1.00 64.79  ? 345  THR A CB    1 ? 
ATOM   2677 O OG1   . THR A 1 366 ? -22.149 -14.102 24.724 1.00 63.92  ? 345  THR A OG1   1 ? 
ATOM   2678 C CG2   . THR A 1 366 ? -23.508 -15.968 25.519 1.00 68.27  ? 345  THR A CG2   1 ? 
ATOM   2679 N N     . LYS A 1 367 ? -22.165 -13.922 21.483 1.00 58.89  ? 346  LYS A N     1 ? 
ATOM   2680 C CA    . LYS A 1 367 ? -21.942 -12.764 20.631 1.00 56.15  ? 346  LYS A CA    1 ? 
ATOM   2681 C C     . LYS A 1 367 ? -22.341 -11.475 21.354 1.00 52.09  ? 346  LYS A C     1 ? 
ATOM   2682 O O     . LYS A 1 367 ? -23.042 -10.646 20.783 1.00 48.56  ? 346  LYS A O     1 ? 
ATOM   2683 C CB    . LYS A 1 367 ? -22.716 -12.886 19.310 1.00 56.11  ? 346  LYS A CB    1 ? 
ATOM   2684 C CG    . LYS A 1 367 ? -22.221 -13.951 18.344 1.00 55.91  ? 346  LYS A CG    1 ? 
ATOM   2685 C CD    . LYS A 1 367 ? -23.030 -13.986 17.048 1.00 60.67  ? 346  LYS A CD    1 ? 
ATOM   2686 C CE    . LYS A 1 367 ? -22.274 -14.361 15.801 1.00 58.92  ? 346  LYS A CE    1 ? 
ATOM   2687 N NZ    . LYS A 1 367 ? -21.332 -15.457 16.031 1.00 61.70  ? 346  LYS A NZ    1 ? 
ATOM   2688 N N     . THR A 1 368 ? -21.830 -11.277 22.578 1.00 56.24  ? 347  THR A N     1 ? 
ATOM   2689 C CA    . THR A 1 368 ? -22.054 -10.046 23.330 1.00 60.11  ? 347  THR A CA    1 ? 
ATOM   2690 C C     . THR A 1 368 ? -20.759 -9.235  23.407 1.00 59.87  ? 347  THR A C     1 ? 
ATOM   2691 O O     . THR A 1 368 ? -20.499 -8.551  24.401 1.00 56.69  ? 347  THR A O     1 ? 
ATOM   2692 C CB    . THR A 1 368 ? -22.594 -10.395 24.718 1.00 65.48  ? 347  THR A CB    1 ? 
ATOM   2693 O OG1   . THR A 1 368 ? -21.627 -11.227 25.355 1.00 74.33  ? 347  THR A OG1   1 ? 
ATOM   2694 C CG2   . THR A 1 368 ? -23.910 -11.148 24.644 1.00 64.44  ? 347  THR A CG2   1 ? 
ATOM   2695 N N     . GLY A 1 369 ? -19.965 -9.290  22.324 1.00 49.08  ? 348  GLY A N     1 ? 
ATOM   2696 C CA    . GLY A 1 369 ? -18.615 -8.744  22.296 1.00 42.25  ? 348  GLY A CA    1 ? 
ATOM   2697 C C     . GLY A 1 369 ? -17.584 -9.864  22.220 1.00 32.70  ? 348  GLY A C     1 ? 
ATOM   2698 O O     . GLY A 1 369 ? -17.647 -10.834 22.969 1.00 33.15  ? 348  GLY A O     1 ? 
ATOM   2699 N N     . ALA A 1 370 ? -16.650 -9.777  21.284 1.00 31.30  ? 349  ALA A N     1 ? 
ATOM   2700 C CA    . ALA A 1 370 ? -15.636 -10.821 21.207 1.00 30.78  ? 349  ALA A CA    1 ? 
ATOM   2701 C C     . ALA A 1 370 ? -14.918 -10.942 22.554 1.00 30.29  ? 349  ALA A C     1 ? 
ATOM   2702 O O     . ALA A 1 370 ? -14.677 -9.933  23.220 1.00 27.67  ? 349  ALA A O     1 ? 
ATOM   2703 C CB    . ALA A 1 370 ? -14.680 -10.548 20.076 1.00 30.31  ? 349  ALA A CB    1 ? 
ATOM   2704 N N     . ASP A 1 371 ? -14.578 -12.183 22.937 1.00 28.37  ? 350  ASP A N     1 ? 
ATOM   2705 C CA    . ASP A 1 371 ? -13.886 -12.449 24.184 1.00 26.85  ? 350  ASP A CA    1 ? 
ATOM   2706 C C     . ASP A 1 371 ? -12.424 -12.824 23.920 1.00 26.75  ? 350  ASP A C     1 ? 
ATOM   2707 O O     . ASP A 1 371 ? -11.592 -12.611 24.816 1.00 25.32  ? 350  ASP A O     1 ? 
ATOM   2708 C CB    . ASP A 1 371 ? -14.663 -13.397 25.095 1.00 28.98  ? 350  ASP A CB    1 ? 
ATOM   2709 C CG    . ASP A 1 371 ? -14.965 -14.791 24.544 1.00 29.93  ? 350  ASP A CG    1 ? 
ATOM   2710 O OD1   . ASP A 1 371 ? -14.802 -14.988 23.327 1.00 28.32  ? 350  ASP A OD1   1 ? 
ATOM   2711 O OD2   . ASP A 1 371 ? -15.339 -15.683 25.354 1.00 34.01  ? 350  ASP A OD2   1 ? 
ATOM   2712 N N     . PHE A 1 372 ? -12.115 -13.350 22.720 1.00 25.65  ? 351  PHE A N     1 ? 
ATOM   2713 C CA    . PHE A 1 372 ? -10.757 -13.696 22.319 1.00 25.65  ? 351  PHE A CA    1 ? 
ATOM   2714 C C     . PHE A 1 372 ? -10.443 -13.183 20.913 1.00 27.36  ? 351  PHE A C     1 ? 
ATOM   2715 O O     . PHE A 1 372 ? -11.312 -13.122 20.027 1.00 29.84  ? 351  PHE A O     1 ? 
ATOM   2716 C CB    . PHE A 1 372 ? -10.426 -15.189 22.391 1.00 26.27  ? 351  PHE A CB    1 ? 
ATOM   2717 C CG    . PHE A 1 372 ? -10.567 -15.705 23.812 1.00 25.44  ? 351  PHE A CG    1 ? 
ATOM   2718 C CD1   . PHE A 1 372 ? -9.502  -15.668 24.699 1.00 26.95  ? 351  PHE A CD1   1 ? 
ATOM   2719 C CD2   . PHE A 1 372 ? -11.783 -16.195 24.268 1.00 27.08  ? 351  PHE A CD2   1 ? 
ATOM   2720 C CE1   . PHE A 1 372 ? -9.662  -16.108 26.009 1.00 25.10  ? 351  PHE A CE1   1 ? 
ATOM   2721 C CE2   . PHE A 1 372 ? -11.940 -16.610 25.583 1.00 25.70  ? 351  PHE A CE2   1 ? 
ATOM   2722 C CZ    . PHE A 1 372 ? -10.879 -16.577 26.445 1.00 23.56  ? 351  PHE A CZ    1 ? 
ATOM   2723 N N     . GLU A 1 373 ? -9.179  -12.787 20.748 1.00 22.25  ? 352  GLU A N     1 ? 
ATOM   2724 C CA    . GLU A 1 373 ? -8.571  -12.572 19.447 1.00 23.12  ? 352  GLU A CA    1 ? 
ATOM   2725 C C     . GLU A 1 373 ? -7.623  -13.728 19.164 1.00 22.93  ? 352  GLU A C     1 ? 
ATOM   2726 O O     . GLU A 1 373 ? -6.881  -14.165 20.054 1.00 22.85  ? 352  GLU A O     1 ? 
ATOM   2727 C CB    . GLU A 1 373 ? -7.858  -11.221 19.388 1.00 23.23  ? 352  GLU A CB    1 ? 
ATOM   2728 C CG    . GLU A 1 373 ? -7.138  -10.922 18.079 1.00 22.95  ? 352  GLU A CG    1 ? 
ATOM   2729 C CD    . GLU A 1 373 ? -6.457  -9.553  18.041 1.00 28.28  ? 352  GLU A CD    1 ? 
ATOM   2730 O OE1   . GLU A 1 373 ? -5.905  -9.183  16.975 1.00 31.19  ? 352  GLU A OE1   1 ? 
ATOM   2731 O OE2   . GLU A 1 373 ? -6.488  -8.849  19.076 1.00 25.25  ? 352  GLU A OE2   1 ? 
ATOM   2732 N N     . LEU A 1 374 ? -7.632  -14.189 17.911 1.00 23.28  ? 353  LEU A N     1 ? 
ATOM   2733 C CA    . LEU A 1 374 ? -6.702  -15.212 17.468 1.00 26.52  ? 353  LEU A CA    1 ? 
ATOM   2734 C C     . LEU A 1 374 ? -5.836  -14.575 16.400 1.00 26.95  ? 353  LEU A C     1 ? 
ATOM   2735 O O     . LEU A 1 374 ? -6.382  -14.093 15.398 1.00 29.55  ? 353  LEU A O     1 ? 
ATOM   2736 C CB    . LEU A 1 374 ? -7.413  -16.448 16.904 1.00 31.41  ? 353  LEU A CB    1 ? 
ATOM   2737 C CG    . LEU A 1 374 ? -8.512  -17.108 17.739 1.00 33.92  ? 353  LEU A CG    1 ? 
ATOM   2738 C CD1   . LEU A 1 374 ? -8.945  -18.433 17.109 1.00 31.02  ? 353  LEU A CD1   1 ? 
ATOM   2739 C CD2   . LEU A 1 374 ? -8.144  -17.332 19.154 1.00 34.70  ? 353  LEU A CD2   1 ? 
ATOM   2740 N N     . ILE A 1 375 ? -4.511  -14.544 16.616 1.00 25.60  ? 354  ILE A N     1 ? 
ATOM   2741 C CA    . ILE A 1 375 ? -3.611  -14.019 15.599 1.00 24.37  ? 354  ILE A CA    1 ? 
ATOM   2742 C C     . ILE A 1 375 ? -2.882  -15.202 14.968 1.00 22.11  ? 354  ILE A C     1 ? 
ATOM   2743 O O     . ILE A 1 375 ? -2.340  -16.015 15.691 1.00 19.60  ? 354  ILE A O     1 ? 
ATOM   2744 C CB    . ILE A 1 375 ? -2.653  -12.962 16.177 1.00 24.51  ? 354  ILE A CB    1 ? 
ATOM   2745 C CG1   . ILE A 1 375 ? -3.469  -11.788 16.769 1.00 26.54  ? 354  ILE A CG1   1 ? 
ATOM   2746 C CG2   . ILE A 1 375 ? -1.649  -12.513 15.123 1.00 25.32  ? 354  ILE A CG2   1 ? 
ATOM   2747 C CD1   . ILE A 1 375 ? -2.663  -10.734 17.482 1.00 26.62  ? 354  ILE A CD1   1 ? 
ATOM   2748 N N     . PHE A 1 376 ? -2.843  -15.254 13.630 1.00 22.97  ? 355  PHE A N     1 ? 
ATOM   2749 C CA    . PHE A 1 376 ? -2.314  -16.413 12.908 1.00 26.17  ? 355  PHE A CA    1 ? 
ATOM   2750 C C     . PHE A 1 376 ? -0.987  -16.108 12.230 1.00 23.60  ? 355  PHE A C     1 ? 
ATOM   2751 O O     . PHE A 1 376 ? -0.835  -15.043 11.664 1.00 25.30  ? 355  PHE A O     1 ? 
ATOM   2752 C CB    . PHE A 1 376 ? -3.344  -16.862 11.869 1.00 28.09  ? 355  PHE A CB    1 ? 
ATOM   2753 C CG    . PHE A 1 376 ? -4.642  -17.375 12.473 1.00 25.96  ? 355  PHE A CG    1 ? 
ATOM   2754 C CD1   . PHE A 1 376 ? -5.640  -16.489 12.862 1.00 27.78  ? 355  PHE A CD1   1 ? 
ATOM   2755 C CD2   . PHE A 1 376 ? -4.861  -18.732 12.641 1.00 26.70  ? 355  PHE A CD2   1 ? 
ATOM   2756 C CE1   . PHE A 1 376 ? -6.815  -16.955 13.418 1.00 28.37  ? 355  PHE A CE1   1 ? 
ATOM   2757 C CE2   . PHE A 1 376 ? -6.035  -19.189 13.193 1.00 26.59  ? 355  PHE A CE2   1 ? 
ATOM   2758 C CZ    . PHE A 1 376 ? -7.005  -18.314 13.580 1.00 28.18  ? 355  PHE A CZ    1 ? 
ATOM   2759 N N     . THR A 1 377 ? -0.018  -17.034 12.330 1.00 25.35  ? 356  THR A N     1 ? 
ATOM   2760 C CA    . THR A 1 377 ? 1.173   -17.040 11.486 1.00 26.63  ? 356  THR A CA    1 ? 
ATOM   2761 C C     . THR A 1 377 ? 1.223   -18.346 10.681 1.00 28.12  ? 356  THR A C     1 ? 
ATOM   2762 O O     . THR A 1 377 ? 0.618   -19.358 11.067 1.00 26.88  ? 356  THR A O     1 ? 
ATOM   2763 C CB    . THR A 1 377 ? 2.460   -16.921 12.292 1.00 26.89  ? 356  THR A CB    1 ? 
ATOM   2764 O OG1   . THR A 1 377 ? 2.580   -18.221 12.858 1.00 27.12  ? 356  THR A OG1   1 ? 
ATOM   2765 C CG2   . THR A 1 377 ? 2.437   -15.872 13.387 1.00 27.47  ? 356  THR A CG2   1 ? 
ATOM   2766 N N     . TYR A 1 378 ? 2.019   -18.300 9.607  1.00 32.98  ? 357  TYR A N     1 ? 
ATOM   2767 C CA    . TYR A 1 378 ? 2.207   -19.407 8.672  1.00 35.23  ? 357  TYR A CA    1 ? 
ATOM   2768 C C     . TYR A 1 378 ? 3.547   -20.095 8.969  1.00 36.28  ? 357  TYR A C     1 ? 
ATOM   2769 O O     . TYR A 1 378 ? 4.114   -20.730 8.082  1.00 35.43  ? 357  TYR A O     1 ? 
ATOM   2770 C CB    . TYR A 1 378 ? 2.101   -18.881 7.227  1.00 31.46  ? 357  TYR A CB    1 ? 
ATOM   2771 C CG    . TYR A 1 378 ? 2.974   -17.678 6.913  1.00 30.12  ? 357  TYR A CG    1 ? 
ATOM   2772 C CD1   . TYR A 1 378 ? 4.335   -17.802 6.699  1.00 30.03  ? 357  TYR A CD1   1 ? 
ATOM   2773 C CD2   . TYR A 1 378 ? 2.430   -16.405 6.872  1.00 33.00  ? 357  TYR A CD2   1 ? 
ATOM   2774 C CE1   . TYR A 1 378 ? 5.131   -16.691 6.481  1.00 33.56  ? 357  TYR A CE1   1 ? 
ATOM   2775 C CE2   . TYR A 1 378 ? 3.204   -15.287 6.628  1.00 30.80  ? 357  TYR A CE2   1 ? 
ATOM   2776 C CZ    . TYR A 1 378 ? 4.563   -15.428 6.455  1.00 30.50  ? 357  TYR A CZ    1 ? 
ATOM   2777 O OH    . TYR A 1 378 ? 5.333   -14.335 6.201  1.00 34.04  ? 357  TYR A OH    1 ? 
ATOM   2778 N N     . THR A 1 379 ? 4.042   -19.936 10.219 1.00 32.02  ? 358  THR A N     1 ? 
ATOM   2779 C CA    . THR A 1 379 ? 5.250   -20.567 10.734 1.00 29.86  ? 358  THR A CA    1 ? 
ATOM   2780 C C     . THR A 1 379 ? 4.948   -21.105 12.139 1.00 33.55  ? 358  THR A C     1 ? 
ATOM   2781 O O     . THR A 1 379 ? 4.073   -20.577 12.829 1.00 32.49  ? 358  THR A O     1 ? 
ATOM   2782 C CB    . THR A 1 379 ? 6.404   -19.568 10.789 1.00 31.94  ? 358  THR A CB    1 ? 
ATOM   2783 O OG1   . THR A 1 379 ? 5.941   -18.470 11.577 1.00 33.40  ? 358  THR A OG1   1 ? 
ATOM   2784 C CG2   . THR A 1 379 ? 6.832   -19.044 9.424  1.00 31.39  ? 358  THR A CG2   1 ? 
ATOM   2785 N N     . HIS A 1 380 ? 5.661   -22.148 12.590 1.00 29.96  ? 359  HIS A N     1 ? 
ATOM   2786 C CA    . HIS A 1 380 ? 5.419   -22.664 13.932 1.00 29.91  ? 359  HIS A CA    1 ? 
ATOM   2787 C C     . HIS A 1 380 ? 5.814   -21.673 15.040 1.00 27.84  ? 359  HIS A C     1 ? 
ATOM   2788 O O     . HIS A 1 380 ? 5.259   -21.752 16.122 1.00 28.87  ? 359  HIS A O     1 ? 
ATOM   2789 C CB    . HIS A 1 380 ? 6.072   -24.026 14.171 1.00 30.02  ? 359  HIS A CB    1 ? 
ATOM   2790 C CG    . HIS A 1 380 ? 7.482   -24.096 13.767 1.00 34.04  ? 359  HIS A CG    1 ? 
ATOM   2791 N ND1   . HIS A 1 380 ? 8.529   -23.374 14.293 1.00 33.63  ? 359  HIS A ND1   1 ? 
ATOM   2792 C CD2   . HIS A 1 380 ? 7.992   -24.838 12.762 1.00 35.02  ? 359  HIS A CD2   1 ? 
ATOM   2793 C CE1   . HIS A 1 380 ? 9.643   -23.695 13.641 1.00 36.82  ? 359  HIS A CE1   1 ? 
ATOM   2794 N NE2   . HIS A 1 380 ? 9.334   -24.579 12.701 1.00 34.97  ? 359  HIS A NE2   1 ? 
ATOM   2795 N N     . GLY A 1 381 ? 6.794   -20.797 14.792 1.00 27.92  ? 360  GLY A N     1 ? 
ATOM   2796 C CA    . GLY A 1 381 ? 7.314   -19.877 15.795 1.00 30.99  ? 360  GLY A CA    1 ? 
ATOM   2797 C C     . GLY A 1 381 ? 7.969   -20.597 16.975 1.00 32.34  ? 360  GLY A C     1 ? 
ATOM   2798 O O     . GLY A 1 381 ? 8.013   -20.039 18.059 1.00 30.30  ? 360  GLY A O     1 ? 
ATOM   2799 N N     . ALA A 1 382 ? 8.502   -21.816 16.770 1.00 30.66  ? 361  ALA A N     1 ? 
ATOM   2800 C CA    . ALA A 1 382 ? 9.073   -22.573 17.869 1.00 31.83  ? 361  ALA A CA    1 ? 
ATOM   2801 C C     . ALA A 1 382 ? 10.503  -22.103 18.139 1.00 34.78  ? 361  ALA A C     1 ? 
ATOM   2802 O O     . ALA A 1 382 ? 11.208  -21.717 17.207 1.00 37.69  ? 361  ALA A O     1 ? 
ATOM   2803 C CB    . ALA A 1 382 ? 9.029   -24.029 17.558 1.00 34.90  ? 361  ALA A CB    1 ? 
ATOM   2804 N N     . ASP A 1 383 ? 10.891  -22.070 19.423 1.00 36.36  ? 362  ASP A N     1 ? 
ATOM   2805 C CA    . ASP A 1 383 ? 12.270  -21.823 19.812 1.00 46.33  ? 362  ASP A CA    1 ? 
ATOM   2806 C C     . ASP A 1 383 ? 13.020  -23.146 19.971 1.00 52.92  ? 362  ASP A C     1 ? 
ATOM   2807 O O     . ASP A 1 383 ? 14.236  -23.139 20.093 1.00 59.54  ? 362  ASP A O     1 ? 
ATOM   2808 C CB    . ASP A 1 383 ? 12.361  -20.947 21.050 1.00 49.11  ? 362  ASP A CB    1 ? 
ATOM   2809 C CG    . ASP A 1 383 ? 11.589  -21.480 22.246 1.00 54.10  ? 362  ASP A CG    1 ? 
ATOM   2810 O OD1   . ASP A 1 383 ? 11.776  -22.678 22.552 1.00 59.90  ? 362  ASP A OD1   1 ? 
ATOM   2811 O OD2   . ASP A 1 383 ? 10.766  -20.728 22.815 1.00 47.25  ? 362  ASP A OD2   1 ? 
ATOM   2812 N N     . GLY A 1 384 ? 12.314  -24.282 19.963 1.00 56.46  ? 363  GLY A N     1 ? 
ATOM   2813 C CA    . GLY A 1 384 ? 12.980  -25.576 19.987 1.00 52.64  ? 363  GLY A CA    1 ? 
ATOM   2814 C C     . GLY A 1 384 ? 13.044  -26.174 21.393 1.00 57.02  ? 363  GLY A C     1 ? 
ATOM   2815 O O     . GLY A 1 384 ? 13.250  -27.386 21.529 1.00 58.47  ? 363  GLY A O     1 ? 
ATOM   2816 N N     . THR A 1 385 ? 12.803  -25.351 22.429 1.00 52.73  ? 364  THR A N     1 ? 
ATOM   2817 C CA    . THR A 1 385 ? 12.788  -25.827 23.806 1.00 50.56  ? 364  THR A CA    1 ? 
ATOM   2818 C C     . THR A 1 385 ? 11.386  -26.255 24.257 1.00 47.21  ? 364  THR A C     1 ? 
ATOM   2819 O O     . THR A 1 385 ? 11.193  -26.647 25.401 1.00 47.02  ? 364  THR A O     1 ? 
ATOM   2820 C CB    . THR A 1 385 ? 13.374  -24.745 24.720 1.00 53.84  ? 364  THR A CB    1 ? 
ATOM   2821 O OG1   . THR A 1 385 ? 12.395  -23.720 24.847 1.00 46.58  ? 364  THR A OG1   1 ? 
ATOM   2822 C CG2   . THR A 1 385 ? 14.679  -24.176 24.187 1.00 52.07  ? 364  THR A CG2   1 ? 
ATOM   2823 N N     . GLU A 1 386 ? 10.385  -26.200 23.380 1.00 41.14  ? 365  GLU A N     1 ? 
ATOM   2824 C CA    . GLU A 1 386 ? 9.079   -26.752 23.690 1.00 36.24  ? 365  GLU A CA    1 ? 
ATOM   2825 C C     . GLU A 1 386 ? 9.234   -28.262 23.880 1.00 39.20  ? 365  GLU A C     1 ? 
ATOM   2826 O O     . GLU A 1 386 ? 9.743   -28.951 22.994 1.00 37.07  ? 365  GLU A O     1 ? 
ATOM   2827 C CB    . GLU A 1 386 ? 8.069   -26.433 22.586 1.00 36.49  ? 365  GLU A CB    1 ? 
ATOM   2828 C CG    . GLU A 1 386 ? 7.916   -24.940 22.282 1.00 36.58  ? 365  GLU A CG    1 ? 
ATOM   2829 C CD    . GLU A 1 386 ? 8.952   -24.318 21.366 1.00 34.53  ? 365  GLU A CD    1 ? 
ATOM   2830 O OE1   . GLU A 1 386 ? 9.885   -25.034 20.962 1.00 35.32  ? 365  GLU A OE1   1 ? 
ATOM   2831 O OE2   . GLU A 1 386 ? 8.835   -23.122 21.025 1.00 34.47  ? 365  GLU A OE2   1 ? 
ATOM   2832 N N     . LYS A 1 387 ? 8.776   -28.765 25.031 1.00 39.81  ? 366  LYS A N     1 ? 
ATOM   2833 C CA    . LYS A 1 387 ? 8.910   -30.169 25.390 1.00 42.78  ? 366  LYS A CA    1 ? 
ATOM   2834 C C     . LYS A 1 387 ? 8.349   -31.092 24.310 1.00 40.11  ? 366  LYS A C     1 ? 
ATOM   2835 O O     . LYS A 1 387 ? 8.938   -32.128 24.028 1.00 37.59  ? 366  LYS A O     1 ? 
ATOM   2836 C CB    . LYS A 1 387 ? 8.188   -30.510 26.698 1.00 44.03  ? 366  LYS A CB    1 ? 
ATOM   2837 C CG    . LYS A 1 387 ? 8.689   -29.781 27.933 1.00 46.03  ? 366  LYS A CG    1 ? 
ATOM   2838 C CD    . LYS A 1 387 ? 8.303   -30.488 29.234 1.00 53.14  ? 366  LYS A CD    1 ? 
ATOM   2839 C CE    . LYS A 1 387 ? 8.860   -29.840 30.470 1.00 58.05  ? 366  LYS A CE    1 ? 
ATOM   2840 N NZ    . LYS A 1 387 ? 10.300  -29.584 30.343 1.00 57.89  ? 366  LYS A NZ    1 ? 
ATOM   2841 N N     . GLU A 1 388 ? 7.225   -30.717 23.699 1.00 33.10  ? 367  GLU A N     1 ? 
ATOM   2842 C CA    . GLU A 1 388 ? 6.536   -31.581 22.748 1.00 33.52  ? 367  GLU A CA    1 ? 
ATOM   2843 C C     . GLU A 1 388 ? 7.322   -31.700 21.441 1.00 31.54  ? 367  GLU A C     1 ? 
ATOM   2844 O O     . GLU A 1 388 ? 7.032   -32.564 20.623 1.00 35.45  ? 367  GLU A O     1 ? 
ATOM   2845 C CB    . GLU A 1 388 ? 5.145   -31.059 22.384 1.00 34.98  ? 367  GLU A CB    1 ? 
ATOM   2846 C CG    . GLU A 1 388 ? 4.206   -30.810 23.565 1.00 33.17  ? 367  GLU A CG    1 ? 
ATOM   2847 C CD    . GLU A 1 388 ? 4.443   -29.539 24.373 1.00 31.37  ? 367  GLU A CD    1 ? 
ATOM   2848 O OE1   . GLU A 1 388 ? 5.385   -28.771 24.071 1.00 30.21  ? 367  GLU A OE1   1 ? 
ATOM   2849 O OE2   . GLU A 1 388 ? 3.627   -29.315 25.305 1.00 35.90  ? 367  GLU A OE2   1 ? 
ATOM   2850 N N     . PHE A 1 389 ? 8.274   -30.794 21.213 1.00 32.26  ? 368  PHE A N     1 ? 
ATOM   2851 C CA    . PHE A 1 389 ? 9.043   -30.768 19.982 1.00 33.93  ? 368  PHE A CA    1 ? 
ATOM   2852 C C     . PHE A 1 389 ? 10.472  -31.265 20.225 1.00 39.42  ? 368  PHE A C     1 ? 
ATOM   2853 O O     . PHE A 1 389 ? 11.346  -31.058 19.382 1.00 37.53  ? 368  PHE A O     1 ? 
ATOM   2854 C CB    . PHE A 1 389 ? 9.099   -29.333 19.441 1.00 30.75  ? 368  PHE A CB    1 ? 
ATOM   2855 C CG    . PHE A 1 389 ? 7.757   -28.665 19.154 1.00 30.69  ? 368  PHE A CG    1 ? 
ATOM   2856 C CD1   . PHE A 1 389 ? 6.598   -29.402 18.936 1.00 30.06  ? 368  PHE A CD1   1 ? 
ATOM   2857 C CD2   . PHE A 1 389 ? 7.664   -27.276 19.114 1.00 31.57  ? 368  PHE A CD2   1 ? 
ATOM   2858 C CE1   . PHE A 1 389 ? 5.386   -28.770 18.683 1.00 29.94  ? 368  PHE A CE1   1 ? 
ATOM   2859 C CE2   . PHE A 1 389 ? 6.450   -26.648 18.867 1.00 32.00  ? 368  PHE A CE2   1 ? 
ATOM   2860 C CZ    . PHE A 1 389 ? 5.313   -27.389 18.660 1.00 29.89  ? 368  PHE A CZ    1 ? 
ATOM   2861 N N     . ALA A 1 390 ? 10.712  -31.913 21.372 1.00 43.66  ? 369  ALA A N     1 ? 
ATOM   2862 C CA    . ALA A 1 390 ? 12.070  -32.191 21.832 1.00 45.21  ? 369  ALA A CA    1 ? 
ATOM   2863 C C     . ALA A 1 390 ? 12.859  -33.011 20.807 1.00 44.00  ? 369  ALA A C     1 ? 
ATOM   2864 O O     . ALA A 1 390 ? 14.040  -32.758 20.593 1.00 44.47  ? 369  ALA A O     1 ? 
ATOM   2865 C CB    . ALA A 1 390 ? 12.022  -32.887 23.174 1.00 44.31  ? 369  ALA A CB    1 ? 
ATOM   2866 N N     . ASN A 1 391 ? 12.190  -33.964 20.153 1.00 48.86  ? 370  ASN A N     1 ? 
ATOM   2867 C CA    . ASN A 1 391 ? 12.866  -34.948 19.325 1.00 54.99  ? 370  ASN A CA    1 ? 
ATOM   2868 C C     . ASN A 1 391 ? 12.769  -34.601 17.839 1.00 57.71  ? 370  ASN A C     1 ? 
ATOM   2869 O O     . ASN A 1 391 ? 13.103  -35.444 17.007 1.00 56.52  ? 370  ASN A O     1 ? 
ATOM   2870 C CB    . ASN A 1 391 ? 12.313  -36.343 19.592 1.00 55.60  ? 370  ASN A CB    1 ? 
ATOM   2871 C CG    . ASN A 1 391 ? 12.429  -36.704 21.051 1.00 59.90  ? 370  ASN A CG    1 ? 
ATOM   2872 O OD1   . ASN A 1 391 ? 13.491  -36.523 21.659 1.00 60.59  ? 370  ASN A OD1   1 ? 
ATOM   2873 N ND2   . ASN A 1 391 ? 11.343  -37.182 21.639 1.00 68.16  ? 370  ASN A ND2   1 ? 
ATOM   2874 N N     . ILE A 1 392 ? 12.333  -33.376 17.500 1.00 53.73  ? 371  ILE A N     1 ? 
ATOM   2875 C CA    . ILE A 1 392 ? 12.276  -32.946 16.107 1.00 51.98  ? 371  ILE A CA    1 ? 
ATOM   2876 C C     . ILE A 1 392 ? 13.661  -32.491 15.657 1.00 50.85  ? 371  ILE A C     1 ? 
ATOM   2877 O O     . ILE A 1 392 ? 14.318  -31.709 16.339 1.00 51.30  ? 371  ILE A O     1 ? 
ATOM   2878 C CB    . ILE A 1 392 ? 11.249  -31.820 15.896 1.00 49.84  ? 371  ILE A CB    1 ? 
ATOM   2879 C CG1   . ILE A 1 392 ? 9.830   -32.310 16.180 1.00 52.46  ? 371  ILE A CG1   1 ? 
ATOM   2880 C CG2   . ILE A 1 392 ? 11.396  -31.212 14.492 1.00 45.12  ? 371  ILE A CG2   1 ? 
ATOM   2881 C CD1   . ILE A 1 392 ? 8.762   -31.221 16.112 1.00 57.42  ? 371  ILE A CD1   1 ? 
ATOM   2882 N N     . GLU A 1 393 ? 14.073  -32.955 14.475 1.00 51.09  ? 372  GLU A N     1 ? 
ATOM   2883 C CA    . GLU A 1 393 ? 15.335  -32.537 13.899 1.00 56.11  ? 372  GLU A CA    1 ? 
ATOM   2884 C C     . GLU A 1 393 ? 15.126  -31.285 13.061 1.00 49.37  ? 372  GLU A C     1 ? 
ATOM   2885 O O     . GLU A 1 393 ? 14.131  -31.149 12.360 1.00 53.90  ? 372  GLU A O     1 ? 
ATOM   2886 C CB    . GLU A 1 393 ? 15.968  -33.675 13.100 1.00 65.41  ? 372  GLU A CB    1 ? 
ATOM   2887 C CG    . GLU A 1 393 ? 16.563  -34.740 14.019 1.00 70.39  ? 372  GLU A CG    1 ? 
ATOM   2888 C CD    . GLU A 1 393 ? 17.185  -35.924 13.312 1.00 75.24  ? 372  GLU A CD    1 ? 
ATOM   2889 O OE1   . GLU A 1 393 ? 17.932  -36.642 13.999 1.00 79.78  ? 372  GLU A OE1   1 ? 
ATOM   2890 O OE2   . GLU A 1 393 ? 16.912  -36.131 12.108 1.00 79.74  ? 372  GLU A OE2   1 ? 
ATOM   2891 N N     . ASP A 1 394 ? 16.085  -30.367 13.174 1.00 49.18  ? 373  ASP A N     1 ? 
ATOM   2892 C CA    . ASP A 1 394 ? 16.113  -29.147 12.385 1.00 53.75  ? 373  ASP A CA    1 ? 
ATOM   2893 C C     . ASP A 1 394 ? 14.725  -28.502 12.408 1.00 50.13  ? 373  ASP A C     1 ? 
ATOM   2894 O O     . ASP A 1 394 ? 14.097  -28.327 11.369 1.00 47.07  ? 373  ASP A O     1 ? 
ATOM   2895 C CB    . ASP A 1 394 ? 16.655  -29.439 10.992 1.00 57.32  ? 373  ASP A CB    1 ? 
ATOM   2896 C CG    . ASP A 1 394 ? 17.185  -28.232 10.223 1.00 67.11  ? 373  ASP A CG    1 ? 
ATOM   2897 O OD1   . ASP A 1 394 ? 17.257  -27.138 10.826 1.00 67.54  ? 373  ASP A OD1   1 ? 
ATOM   2898 O OD2   . ASP A 1 394 ? 17.524  -28.389 9.024  1.00 74.61  ? 373  ASP A OD2   1 ? 
ATOM   2899 N N     . ILE A 1 395 ? 14.266  -28.149 13.615 1.00 48.03  ? 374  ILE A N     1 ? 
ATOM   2900 C CA    . ILE A 1 395 ? 12.936  -27.591 13.831 1.00 43.10  ? 374  ILE A CA    1 ? 
ATOM   2901 C C     . ILE A 1 395 ? 12.755  -26.367 12.933 1.00 34.18  ? 374  ILE A C     1 ? 
ATOM   2902 O O     . ILE A 1 395 ? 11.707  -26.199 12.313 1.00 34.63  ? 374  ILE A O     1 ? 
ATOM   2903 C CB    . ILE A 1 395 ? 12.706  -27.266 15.326 1.00 45.38  ? 374  ILE A CB    1 ? 
ATOM   2904 C CG1   . ILE A 1 395 ? 11.269  -26.821 15.608 1.00 46.81  ? 374  ILE A CG1   1 ? 
ATOM   2905 C CG2   . ILE A 1 395 ? 13.717  -26.241 15.853 1.00 47.13  ? 374  ILE A CG2   1 ? 
ATOM   2906 C CD1   . ILE A 1 395 ? 10.381  -27.916 16.154 1.00 50.30  ? 374  ILE A CD1   1 ? 
ATOM   2907 N N     . GLN A 1 396 ? 13.789  -25.533 12.841 1.00 36.79  ? 375  GLN A N     1 ? 
ATOM   2908 C CA    . GLN A 1 396 ? 13.701  -24.268 12.134 1.00 45.19  ? 375  GLN A CA    1 ? 
ATOM   2909 C C     . GLN A 1 396 ? 13.463  -24.464 10.638 1.00 46.69  ? 375  GLN A C     1 ? 
ATOM   2910 O O     . GLN A 1 396 ? 12.983  -23.548 9.977  1.00 47.07  ? 375  GLN A O     1 ? 
ATOM   2911 C CB    . GLN A 1 396 ? 14.961  -23.423 12.329 1.00 52.07  ? 375  GLN A CB    1 ? 
ATOM   2912 C CG    . GLN A 1 396 ? 15.087  -22.827 13.729 1.00 61.05  ? 375  GLN A CG    1 ? 
ATOM   2913 C CD    . GLN A 1 396 ? 13.803  -22.189 14.228 1.00 65.45  ? 375  GLN A CD    1 ? 
ATOM   2914 O OE1   . GLN A 1 396 ? 13.218  -21.327 13.567 1.00 69.15  ? 375  GLN A OE1   1 ? 
ATOM   2915 N NE2   . GLN A 1 396 ? 13.335  -22.616 15.394 1.00 70.73  ? 375  GLN A NE2   1 ? 
ATOM   2916 N N     . ALA A 1 397 ? 13.820  -25.637 10.104 1.00 45.94  ? 376  ALA A N     1 ? 
ATOM   2917 C CA    . ALA A 1 397 ? 13.630  -25.903 8.686  1.00 46.29  ? 376  ALA A CA    1 ? 
ATOM   2918 C C     . ALA A 1 397 ? 12.253  -26.507 8.421  1.00 41.73  ? 376  ALA A C     1 ? 
ATOM   2919 O O     . ALA A 1 397 ? 11.840  -26.565 7.268  1.00 39.60  ? 376  ALA A O     1 ? 
ATOM   2920 C CB    . ALA A 1 397 ? 14.730  -26.809 8.186  1.00 51.52  ? 376  ALA A CB    1 ? 
ATOM   2921 N N     . GLN A 1 398 ? 11.549  -26.921 9.484  1.00 36.70  ? 377  GLN A N     1 ? 
ATOM   2922 C CA    . GLN A 1 398 ? 10.242  -27.551 9.361  1.00 36.93  ? 377  GLN A CA    1 ? 
ATOM   2923 C C     . GLN A 1 398 ? 9.127   -26.520 9.201  1.00 38.95  ? 377  GLN A C     1 ? 
ATOM   2924 O O     . GLN A 1 398 ? 9.204   -25.425 9.744  1.00 38.75  ? 377  GLN A O     1 ? 
ATOM   2925 C CB    . GLN A 1 398 ? 9.857   -28.348 10.601 1.00 36.46  ? 377  GLN A CB    1 ? 
ATOM   2926 C CG    . GLN A 1 398 ? 10.872  -29.409 10.994 1.00 40.01  ? 377  GLN A CG    1 ? 
ATOM   2927 C CD    . GLN A 1 398 ? 11.209  -30.319 9.835  1.00 39.74  ? 377  GLN A CD    1 ? 
ATOM   2928 O OE1   . GLN A 1 398 ? 10.335  -30.768 9.082  1.00 38.55  ? 377  GLN A OE1   1 ? 
ATOM   2929 N NE2   . GLN A 1 398 ? 12.493  -30.572 9.681  1.00 40.50  ? 377  GLN A NE2   1 ? 
ATOM   2930 N N     . SER A 1 399 ? 8.082   -26.934 8.472  1.00 36.33  ? 378  SER A N     1 ? 
ATOM   2931 C CA    . SER A 1 399 ? 6.870   -26.167 8.279  1.00 34.10  ? 378  SER A CA    1 ? 
ATOM   2932 C C     . SER A 1 399 ? 5.985   -26.239 9.521  1.00 30.87  ? 378  SER A C     1 ? 
ATOM   2933 O O     . SER A 1 399 ? 6.083   -27.165 10.321 1.00 28.90  ? 378  SER A O     1 ? 
ATOM   2934 C CB    . SER A 1 399 ? 6.122   -26.668 7.063  1.00 32.19  ? 378  SER A CB    1 ? 
ATOM   2935 O OG    . SER A 1 399 ? 6.742   -26.243 5.863  1.00 33.46  ? 378  SER A OG    1 ? 
ATOM   2936 N N     . GLY A 1 400 ? 5.086   -25.265 9.638  1.00 28.66  ? 379  GLY A N     1 ? 
ATOM   2937 C CA    . GLY A 1 400 ? 4.108   -25.239 10.708 1.00 29.65  ? 379  GLY A CA    1 ? 
ATOM   2938 C C     . GLY A 1 400 ? 3.379   -23.897 10.765 1.00 29.01  ? 379  GLY A C     1 ? 
ATOM   2939 O O     . GLY A 1 400 ? 3.609   -23.015 9.928  1.00 32.84  ? 379  GLY A O     1 ? 
ATOM   2940 N N     . TYR A 1 401 ? 2.492   -23.774 11.758 1.00 28.58  ? 380  TYR A N     1 ? 
ATOM   2941 C CA    . TYR A 1 401 ? 1.675   -22.581 11.918 1.00 28.08  ? 380  TYR A CA    1 ? 
ATOM   2942 C C     . TYR A 1 401 ? 1.422   -22.346 13.412 1.00 28.59  ? 380  TYR A C     1 ? 
ATOM   2943 O O     . TYR A 1 401 ? 1.722   -23.200 14.247 1.00 23.86  ? 380  TYR A O     1 ? 
ATOM   2944 C CB    . TYR A 1 401 ? 0.387   -22.719 11.106 1.00 27.70  ? 380  TYR A CB    1 ? 
ATOM   2945 C CG    . TYR A 1 401 ? -0.625  -23.696 11.666 1.00 27.59  ? 380  TYR A CG    1 ? 
ATOM   2946 C CD1   . TYR A 1 401 ? -0.523  -25.062 11.427 1.00 31.74  ? 380  TYR A CD1   1 ? 
ATOM   2947 C CD2   . TYR A 1 401 ? -1.709  -23.243 12.406 1.00 25.27  ? 380  TYR A CD2   1 ? 
ATOM   2948 C CE1   . TYR A 1 401 ? -1.446  -25.948 11.957 1.00 30.34  ? 380  TYR A CE1   1 ? 
ATOM   2949 C CE2   . TYR A 1 401 ? -2.653  -24.108 12.909 1.00 26.25  ? 380  TYR A CE2   1 ? 
ATOM   2950 C CZ    . TYR A 1 401 ? -2.512  -25.474 12.699 1.00 30.02  ? 380  TYR A CZ    1 ? 
ATOM   2951 O OH    . TYR A 1 401 ? -3.449  -26.296 13.265 1.00 28.04  ? 380  TYR A OH    1 ? 
ATOM   2952 N N     . SER A 1 402 ? 0.902   -21.159 13.742 1.00 26.95  ? 381  SER A N     1 ? 
ATOM   2953 C CA    . SER A 1 402 ? 0.651   -20.834 15.136 1.00 25.57  ? 381  SER A CA    1 ? 
ATOM   2954 C C     . SER A 1 402 ? -0.557  -19.906 15.258 1.00 26.71  ? 381  SER A C     1 ? 
ATOM   2955 O O     . SER A 1 402 ? -0.901  -19.157 14.347 1.00 23.76  ? 381  SER A O     1 ? 
ATOM   2956 C CB    . SER A 1 402 ? 1.875   -20.250 15.806 1.00 26.01  ? 381  SER A CB    1 ? 
ATOM   2957 O OG    . SER A 1 402 ? 2.045   -18.893 15.438 1.00 26.10  ? 381  SER A OG    1 ? 
ATOM   2958 N N     . VAL A 1 403 ? -1.217  -20.012 16.419 1.00 23.51  ? 382  VAL A N     1 ? 
ATOM   2959 C CA    . VAL A 1 403 ? -2.380  -19.220 16.725 1.00 24.89  ? 382  VAL A CA    1 ? 
ATOM   2960 C C     . VAL A 1 403 ? -2.142  -18.626 18.106 1.00 25.81  ? 382  VAL A C     1 ? 
ATOM   2961 O O     . VAL A 1 403 ? -1.991  -19.365 19.089 1.00 22.66  ? 382  VAL A O     1 ? 
ATOM   2962 C CB    . VAL A 1 403 ? -3.683  -20.040 16.686 1.00 25.00  ? 382  VAL A CB    1 ? 
ATOM   2963 C CG1   . VAL A 1 403 ? -4.895  -19.137 16.803 1.00 26.79  ? 382  VAL A CG1   1 ? 
ATOM   2964 C CG2   . VAL A 1 403 ? -3.779  -20.935 15.453 1.00 27.09  ? 382  VAL A CG2   1 ? 
ATOM   2965 N N     . THR A 1 404 ? -2.065  -17.295 18.144 1.00 25.17  ? 383  THR A N     1 ? 
ATOM   2966 C CA    . THR A 1 404 ? -1.838  -16.595 19.397 1.00 23.74  ? 383  THR A CA    1 ? 
ATOM   2967 C C     . THR A 1 404 ? -3.189  -16.170 19.969 1.00 23.36  ? 383  THR A C     1 ? 
ATOM   2968 O O     . THR A 1 404 ? -3.952  -15.462 19.302 1.00 22.35  ? 383  THR A O     1 ? 
ATOM   2969 C CB    . THR A 1 404 ? -0.934  -15.396 19.117 1.00 26.17  ? 383  THR A CB    1 ? 
ATOM   2970 O OG1   . THR A 1 404 ? 0.323   -15.951 18.747 1.00 22.82  ? 383  THR A OG1   1 ? 
ATOM   2971 C CG2   . THR A 1 404 ? -0.721  -14.542 20.357 1.00 24.58  ? 383  THR A CG2   1 ? 
ATOM   2972 N N     . VAL A 1 405 ? -3.466  -16.606 21.204 1.00 20.63  ? 384  VAL A N     1 ? 
ATOM   2973 C CA    . VAL A 1 405 ? -4.737  -16.370 21.848 1.00 20.86  ? 384  VAL A CA    1 ? 
ATOM   2974 C C     . VAL A 1 405 ? -4.592  -15.176 22.787 1.00 20.41  ? 384  VAL A C     1 ? 
ATOM   2975 O O     . VAL A 1 405 ? -3.698  -15.175 23.616 1.00 19.04  ? 384  VAL A O     1 ? 
ATOM   2976 C CB    . VAL A 1 405 ? -5.153  -17.650 22.603 1.00 21.36  ? 384  VAL A CB    1 ? 
ATOM   2977 C CG1   . VAL A 1 405 ? -6.466  -17.444 23.322 1.00 22.34  ? 384  VAL A CG1   1 ? 
ATOM   2978 C CG2   . VAL A 1 405 ? -5.230  -18.863 21.672 1.00 22.90  ? 384  VAL A CG2   1 ? 
ATOM   2979 N N     . ILE A 1 406 ? -5.529  -14.217 22.695 1.00 20.58  ? 385  ILE A N     1 ? 
ATOM   2980 C CA    . ILE A 1 406 ? -5.529  -13.030 23.536 1.00 20.67  ? 385  ILE A CA    1 ? 
ATOM   2981 C C     . ILE A 1 406 ? -6.879  -12.906 24.218 1.00 20.63  ? 385  ILE A C     1 ? 
ATOM   2982 O O     . ILE A 1 406 ? -7.918  -12.840 23.553 1.00 21.91  ? 385  ILE A O     1 ? 
ATOM   2983 C CB    . ILE A 1 406 ? -5.209  -11.754 22.738 1.00 20.51  ? 385  ILE A CB    1 ? 
ATOM   2984 C CG1   . ILE A 1 406 ? -3.875  -11.853 22.059 1.00 22.61  ? 385  ILE A CG1   1 ? 
ATOM   2985 C CG2   . ILE A 1 406 ? -5.295  -10.526 23.646 1.00 22.30  ? 385  ILE A CG2   1 ? 
ATOM   2986 C CD1   . ILE A 1 406 ? -3.702  -10.913 20.883 1.00 24.80  ? 385  ILE A CD1   1 ? 
ATOM   2987 N N     . LEU A 1 407 ? -6.843  -12.873 25.566 1.00 20.82  ? 386  LEU A N     1 ? 
ATOM   2988 C CA    . LEU A 1 407 ? -8.017  -12.587 26.366 1.00 19.27  ? 386  LEU A CA    1 ? 
ATOM   2989 C C     . LEU A 1 407 ? -8.256  -11.081 26.253 1.00 19.49  ? 386  LEU A C     1 ? 
ATOM   2990 O O     . LEU A 1 407 ? -7.469  -10.284 26.742 1.00 18.93  ? 386  LEU A O     1 ? 
ATOM   2991 C CB    . LEU A 1 407 ? -7.829  -13.038 27.814 1.00 20.76  ? 386  LEU A CB    1 ? 
ATOM   2992 C CG    . LEU A 1 407 ? -8.973  -12.673 28.775 1.00 23.42  ? 386  LEU A CG    1 ? 
ATOM   2993 C CD1   . LEU A 1 407 ? -10.259 -13.489 28.455 1.00 23.85  ? 386  LEU A CD1   1 ? 
ATOM   2994 C CD2   . LEU A 1 407 ? -8.620  -12.878 30.223 1.00 22.51  ? 386  LEU A CD2   1 ? 
ATOM   2995 N N     . LEU A 1 408 ? -9.350  -10.697 25.585 1.00 20.85  ? 387  LEU A N     1 ? 
ATOM   2996 C CA    . LEU A 1 408 ? -9.526  -9.319  25.162 1.00 21.22  ? 387  LEU A CA    1 ? 
ATOM   2997 C C     . LEU A 1 408 ? -9.978  -8.408  26.289 1.00 19.91  ? 387  LEU A C     1 ? 
ATOM   2998 O O     . LEU A 1 408 ? -9.690  -7.211  26.234 1.00 22.49  ? 387  LEU A O     1 ? 
ATOM   2999 C CB    . LEU A 1 408 ? -10.506 -9.291  23.993 1.00 22.60  ? 387  LEU A CB    1 ? 
ATOM   3000 C CG    . LEU A 1 408 ? -9.942  -9.832  22.686 1.00 23.47  ? 387  LEU A CG    1 ? 
ATOM   3001 C CD1   . LEU A 1 408 ? -11.015 -9.836  21.585 1.00 25.09  ? 387  LEU A CD1   1 ? 
ATOM   3002 C CD2   . LEU A 1 408 ? -8.724  -9.001  22.273 1.00 24.14  ? 387  LEU A CD2   1 ? 
ATOM   3003 N N     . GLN A 1 409 ? -10.711 -8.922  27.292 1.00 19.31  ? 388  GLN A N     1 ? 
ATOM   3004 C CA    . GLN A 1 409 ? -11.217 -8.046  28.342 1.00 19.39  ? 388  GLN A CA    1 ? 
ATOM   3005 C C     . GLN A 1 409 ? -10.791 -8.577  29.710 1.00 20.85  ? 388  GLN A C     1 ? 
ATOM   3006 O O     . GLN A 1 409 ? -11.612 -9.025  30.509 1.00 21.07  ? 388  GLN A O     1 ? 
ATOM   3007 C CB    . GLN A 1 409 ? -12.720 -7.828  28.194 1.00 21.26  ? 388  GLN A CB    1 ? 
ATOM   3008 C CG    . GLN A 1 409 ? -13.094 -7.229  26.842 1.00 25.67  ? 388  GLN A CG    1 ? 
ATOM   3009 C CD    . GLN A 1 409 ? -12.849 -5.734  26.800 1.00 30.76  ? 388  GLN A CD    1 ? 
ATOM   3010 O OE1   . GLN A 1 409 ? -13.617 -4.956  27.390 1.00 39.01  ? 388  GLN A OE1   1 ? 
ATOM   3011 N NE2   . GLN A 1 409 ? -11.789 -5.317  26.113 1.00 29.03  ? 388  GLN A NE2   1 ? 
ATOM   3012 N N     . PRO A 1 410 ? -9.489  -8.490  30.050 1.00 20.97  ? 389  PRO A N     1 ? 
ATOM   3013 C CA    . PRO A 1 410 ? -9.018  -8.916  31.373 1.00 22.86  ? 389  PRO A CA    1 ? 
ATOM   3014 C C     . PRO A 1 410 ? -9.648  -8.021  32.428 1.00 22.97  ? 389  PRO A C     1 ? 
ATOM   3015 O O     . PRO A 1 410 ? -9.825  -6.821  32.197 1.00 22.87  ? 389  PRO A O     1 ? 
ATOM   3016 C CB    . PRO A 1 410 ? -7.502  -8.727  31.273 1.00 22.02  ? 389  PRO A CB    1 ? 
ATOM   3017 C CG    . PRO A 1 410 ? -7.365  -7.592  30.276 1.00 20.83  ? 389  PRO A CG    1 ? 
ATOM   3018 C CD    . PRO A 1 410 ? -8.414  -7.925  29.223 1.00 20.72  ? 389  PRO A CD    1 ? 
ATOM   3019 N N     . LYS A 1 411 ? -9.996  -8.606  33.586 1.00 22.26  ? 390  LYS A N     1 ? 
ATOM   3020 C CA    . LYS A 1 411 ? -10.498 -7.817  34.691 1.00 21.69  ? 390  LYS A CA    1 ? 
ATOM   3021 C C     . LYS A 1 411 ? -9.385  -7.326  35.615 1.00 20.41  ? 390  LYS A C     1 ? 
ATOM   3022 O O     . LYS A 1 411 ? -9.626  -6.420  36.405 1.00 20.10  ? 390  LYS A O     1 ? 
ATOM   3023 C CB    . LYS A 1 411 ? -11.507 -8.607  35.532 1.00 23.43  ? 390  LYS A CB    1 ? 
ATOM   3024 C CG    . LYS A 1 411 ? -12.814 -8.898  34.821 1.00 28.35  ? 390  LYS A CG    1 ? 
ATOM   3025 C CD    . LYS A 1 411 ? -13.749 -9.842  35.580 1.00 35.91  ? 390  LYS A CD    1 ? 
ATOM   3026 C CE    . LYS A 1 411 ? -14.685 -10.638 34.676 1.00 42.93  ? 390  LYS A CE    1 ? 
ATOM   3027 N NZ    . LYS A 1 411 ? -15.388 -9.748  33.730 1.00 42.61  ? 390  LYS A NZ    1 ? 
ATOM   3028 N N     . SER A 1 412 ? -8.198  -7.941  35.564 1.00 19.23  ? 391  SER A N     1 ? 
ATOM   3029 C CA    . SER A 1 412 ? -7.065  -7.545  36.388 1.00 19.72  ? 391  SER A CA    1 ? 
ATOM   3030 C C     . SER A 1 412 ? -6.710  -6.074  36.171 1.00 21.49  ? 391  SER A C     1 ? 
ATOM   3031 O O     . SER A 1 412 ? -6.728  -5.582  35.048 1.00 21.48  ? 391  SER A O     1 ? 
ATOM   3032 C CB    . SER A 1 412 ? -5.860  -8.403  36.090 1.00 19.38  ? 391  SER A CB    1 ? 
ATOM   3033 O OG    . SER A 1 412 ? -6.115  -9.750  36.445 1.00 20.77  ? 391  SER A OG    1 ? 
ATOM   3034 N N     . ARG A 1 413 ? -6.422  -5.367  37.266 1.00 22.59  ? 392  ARG A N     1 ? 
ATOM   3035 C CA    . ARG A 1 413 ? -5.986  -3.985  37.215 1.00 21.04  ? 392  ARG A CA    1 ? 
ATOM   3036 C C     . ARG A 1 413 ? -4.779  -3.819  38.120 1.00 20.47  ? 392  ARG A C     1 ? 
ATOM   3037 O O     . ARG A 1 413 ? -4.723  -4.447  39.168 1.00 21.29  ? 392  ARG A O     1 ? 
ATOM   3038 C CB    . ARG A 1 413 ? -7.048  -3.004  37.728 1.00 20.11  ? 392  ARG A CB    1 ? 
ATOM   3039 C CG    . ARG A 1 413 ? -8.278  -2.912  36.848 1.00 20.35  ? 392  ARG A CG    1 ? 
ATOM   3040 C CD    . ARG A 1 413 ? -7.904  -2.494  35.448 1.00 19.77  ? 392  ARG A CD    1 ? 
ATOM   3041 N NE    . ARG A 1 413 ? -9.130  -2.301  34.662 1.00 20.68  ? 392  ARG A NE    1 ? 
ATOM   3042 C CZ    . ARG A 1 413 ? -9.614  -3.195  33.792 1.00 20.11  ? 392  ARG A CZ    1 ? 
ATOM   3043 N NH1   . ARG A 1 413 ? -9.087  -4.389  33.701 1.00 21.59  ? 392  ARG A NH1   1 ? 
ATOM   3044 N NH2   . ARG A 1 413 ? -10.596 -2.866  32.980 1.00 21.28  ? 392  ARG A NH2   1 ? 
ATOM   3045 N N     . GLY A 1 414 ? -3.803  -3.009  37.683 1.00 18.98  ? 393  GLY A N     1 ? 
ATOM   3046 C CA    . GLY A 1 414 ? -2.608  -2.756  38.468 1.00 16.91  ? 393  GLY A CA    1 ? 
ATOM   3047 C C     . GLY A 1 414 ? -2.285  -1.264  38.588 1.00 17.91  ? 393  GLY A C     1 ? 
ATOM   3048 O O     . GLY A 1 414 ? -3.175  -0.381  38.552 1.00 17.24  ? 393  GLY A O     1 ? 
ATOM   3049 N N     . GLN A 1 415 ? -0.978  -0.993  38.716 1.00 18.13  ? 394  GLN A N     1 ? 
ATOM   3050 C CA    . GLN A 1 415 ? -0.528  0.308   39.179 1.00 19.11  ? 394  GLN A CA    1 ? 
ATOM   3051 C C     . GLN A 1 415 ? 0.751   0.708   38.457 1.00 18.99  ? 394  GLN A C     1 ? 
ATOM   3052 O O     . GLN A 1 415 ? 1.605   -0.129  38.109 1.00 18.47  ? 394  GLN A O     1 ? 
ATOM   3053 C CB    . GLN A 1 415 ? -0.141  0.288   40.655 1.00 19.68  ? 394  GLN A CB    1 ? 
ATOM   3054 C CG    . GLN A 1 415 ? -1.303  0.036   41.580 1.00 19.65  ? 394  GLN A CG    1 ? 
ATOM   3055 C CD    . GLN A 1 415 ? -0.899  0.138   43.033 1.00 23.96  ? 394  GLN A CD    1 ? 
ATOM   3056 O OE1   . GLN A 1 415 ? -1.358  0.998   43.791 1.00 26.47  ? 394  GLN A OE1   1 ? 
ATOM   3057 N NE2   . GLN A 1 415 ? -0.016  -0.751  43.419 1.00 22.60  ? 394  GLN A NE2   1 ? 
ATOM   3058 N N     . LEU A 1 416 ? 0.855   2.014   38.273 1.00 19.02  ? 395  LEU A N     1 ? 
ATOM   3059 C CA    . LEU A 1 416 ? 2.085   2.653   37.855 1.00 18.67  ? 395  LEU A CA    1 ? 
ATOM   3060 C C     . LEU A 1 416 ? 2.525   3.591   38.979 1.00 18.18  ? 395  LEU A C     1 ? 
ATOM   3061 O O     . LEU A 1 416 ? 1.866   4.596   39.227 1.00 17.17  ? 395  LEU A O     1 ? 
ATOM   3062 C CB    . LEU A 1 416 ? 1.917   3.432   36.558 1.00 18.72  ? 395  LEU A CB    1 ? 
ATOM   3063 C CG    . LEU A 1 416 ? 3.329   3.857   36.156 1.00 22.51  ? 395  LEU A CG    1 ? 
ATOM   3064 C CD1   . LEU A 1 416 ? 3.860   3.062   35.021 1.00 23.56  ? 395  LEU A CD1   1 ? 
ATOM   3065 C CD2   . LEU A 1 416 ? 3.599   5.319   36.187 1.00 22.08  ? 395  LEU A CD2   1 ? 
ATOM   3066 N N     . LEU A 1 417 ? 3.603   3.225   39.663 1.00 20.47  ? 396  LEU A N     1 ? 
ATOM   3067 C CA    . LEU A 1 417 ? 4.060   3.896   40.870 1.00 20.45  ? 396  LEU A CA    1 ? 
ATOM   3068 C C     . LEU A 1 417 ? 5.384   4.589   40.573 1.00 22.22  ? 396  LEU A C     1 ? 
ATOM   3069 O O     . LEU A 1 417 ? 6.168   4.093   39.747 1.00 20.03  ? 396  LEU A O     1 ? 
ATOM   3070 C CB    . LEU A 1 417 ? 4.252   2.897   42.012 1.00 20.96  ? 396  LEU A CB    1 ? 
ATOM   3071 C CG    . LEU A 1 417 ? 3.025   2.060   42.394 1.00 20.39  ? 396  LEU A CG    1 ? 
ATOM   3072 C CD1   . LEU A 1 417 ? 3.286   1.125   43.579 1.00 22.63  ? 396  LEU A CD1   1 ? 
ATOM   3073 C CD2   . LEU A 1 417 ? 1.871   2.983   42.732 1.00 21.27  ? 396  LEU A CD2   1 ? 
ATOM   3074 N N     . LEU A 1 418 ? 5.669   5.658   41.339 1.00 20.94  ? 397  LEU A N     1 ? 
ATOM   3075 C CA    . LEU A 1 418 ? 6.999   6.266   41.329 1.00 21.68  ? 397  LEU A CA    1 ? 
ATOM   3076 C C     . LEU A 1 418 ? 7.995   5.359   42.044 1.00 21.91  ? 397  LEU A C     1 ? 
ATOM   3077 O O     . LEU A 1 418 ? 7.652   4.738   43.041 1.00 22.18  ? 397  LEU A O     1 ? 
ATOM   3078 C CB    . LEU A 1 418 ? 6.983   7.628   42.022 1.00 19.77  ? 397  LEU A CB    1 ? 
ATOM   3079 C CG    . LEU A 1 418 ? 6.199   8.757   41.350 1.00 20.61  ? 397  LEU A CG    1 ? 
ATOM   3080 C CD1   . LEU A 1 418 ? 6.334   9.998   42.216 1.00 22.46  ? 397  LEU A CD1   1 ? 
ATOM   3081 C CD2   . LEU A 1 418 ? 6.688   9.036   39.955 1.00 20.40  ? 397  LEU A CD2   1 ? 
ATOM   3082 N N     . ALA A 1 419 ? 9.247   5.326   41.568 1.00 21.77  ? 398  ALA A N     1 ? 
ATOM   3083 C CA    . ALA A 1 419 ? 10.329  4.686   42.317 1.00 23.19  ? 398  ALA A CA    1 ? 
ATOM   3084 C C     . ALA A 1 419 ? 10.960  5.688   43.275 1.00 23.90  ? 398  ALA A C     1 ? 
ATOM   3085 O O     . ALA A 1 419 ? 11.503  5.305   44.304 1.00 25.39  ? 398  ALA A O     1 ? 
ATOM   3086 C CB    . ALA A 1 419 ? 11.386  4.159   41.363 1.00 23.89  ? 398  ALA A CB    1 ? 
ATOM   3087 N N     . SER A 1 420 ? 10.883  6.978   42.918 1.00 24.08  ? 399  SER A N     1 ? 
ATOM   3088 C CA    . SER A 1 420 ? 11.661  8.028   43.574 1.00 25.49  ? 399  SER A CA    1 ? 
ATOM   3089 C C     . SER A 1 420 ? 11.176  9.376   43.052 1.00 26.18  ? 399  SER A C     1 ? 
ATOM   3090 O O     . SER A 1 420 ? 10.306  9.415   42.166 1.00 23.61  ? 399  SER A O     1 ? 
ATOM   3091 C CB    . SER A 1 420 ? 13.129  7.863   43.293 1.00 24.82  ? 399  SER A CB    1 ? 
ATOM   3092 O OG    . SER A 1 420 ? 13.420  8.306   41.974 1.00 22.44  ? 399  SER A OG    1 ? 
ATOM   3093 N N     . THR A 1 421 ? 11.774  10.466  43.553 1.00 25.85  ? 400  THR A N     1 ? 
ATOM   3094 C CA    . THR A 1 421 ? 11.468  11.794  43.031 1.00 25.11  ? 400  THR A CA    1 ? 
ATOM   3095 C C     . THR A 1 421 ? 12.464  12.168  41.936 1.00 23.56  ? 400  THR A C     1 ? 
ATOM   3096 O O     . THR A 1 421 ? 12.425  13.277  41.388 1.00 24.41  ? 400  THR A O     1 ? 
ATOM   3097 C CB    . THR A 1 421 ? 11.493  12.842  44.146 1.00 26.23  ? 400  THR A CB    1 ? 
ATOM   3098 O OG1   . THR A 1 421 ? 12.800  12.800  44.704 1.00 25.37  ? 400  THR A OG1   1 ? 
ATOM   3099 C CG2   . THR A 1 421 ? 10.510  12.536  45.255 1.00 27.49  ? 400  THR A CG2   1 ? 
ATOM   3100 N N     . ASN A 1 422 ? 13.357  11.259  41.595 1.00 22.97  ? 401  ASN A N     1 ? 
ATOM   3101 C CA    . ASN A 1 422 ? 14.331  11.541  40.552 1.00 21.81  ? 401  ASN A CA    1 ? 
ATOM   3102 C C     . ASN A 1 422 ? 13.652  11.414  39.192 1.00 23.08  ? 401  ASN A C     1 ? 
ATOM   3103 O O     . ASN A 1 422 ? 13.180  10.329  38.840 1.00 24.83  ? 401  ASN A O     1 ? 
ATOM   3104 C CB    . ASN A 1 422 ? 15.530  10.626  40.727 1.00 21.95  ? 401  ASN A CB    1 ? 
ATOM   3105 C CG    . ASN A 1 422 ? 16.603  10.941  39.731 1.00 24.85  ? 401  ASN A CG    1 ? 
ATOM   3106 O OD1   . ASN A 1 422 ? 16.341  11.122  38.543 1.00 24.02  ? 401  ASN A OD1   1 ? 
ATOM   3107 N ND2   . ASN A 1 422 ? 17.801  11.147  40.230 1.00 33.89  ? 401  ASN A ND2   1 ? 
ATOM   3108 N N     . PRO A 1 423 ? 13.600  12.494  38.385 1.00 23.34  ? 402  PRO A N     1 ? 
ATOM   3109 C CA    . PRO A 1 423 ? 12.856  12.467  37.130 1.00 23.98  ? 402  PRO A CA    1 ? 
ATOM   3110 C C     . PRO A 1 423 ? 13.378  11.467  36.094 1.00 20.42  ? 402  PRO A C     1 ? 
ATOM   3111 O O     . PRO A 1 423 ? 12.677  11.194  35.133 1.00 21.69  ? 402  PRO A O     1 ? 
ATOM   3112 C CB    . PRO A 1 423 ? 12.948  13.916  36.625 1.00 23.11  ? 402  PRO A CB    1 ? 
ATOM   3113 C CG    . PRO A 1 423 ? 14.150  14.533  37.319 1.00 24.21  ? 402  PRO A CG    1 ? 
ATOM   3114 C CD    . PRO A 1 423 ? 14.224  13.816  38.648 1.00 25.04  ? 402  PRO A CD    1 ? 
ATOM   3115 N N     . TYR A 1 424 ? 14.592  10.957  36.277 1.00 21.39  ? 403  TYR A N     1 ? 
ATOM   3116 C CA    . TYR A 1 424 ? 15.181  10.065  35.289 1.00 25.24  ? 403  TYR A CA    1 ? 
ATOM   3117 C C     . TYR A 1 424 ? 14.885  8.599   35.611 1.00 24.84  ? 403  TYR A C     1 ? 
ATOM   3118 O O     . TYR A 1 424 ? 15.063  7.748   34.746 1.00 26.64  ? 403  TYR A O     1 ? 
ATOM   3119 C CB    . TYR A 1 424 ? 16.686  10.335  35.167 1.00 27.88  ? 403  TYR A CB    1 ? 
ATOM   3120 C CG    . TYR A 1 424 ? 16.970  11.758  34.688 1.00 26.13  ? 403  TYR A CG    1 ? 
ATOM   3121 C CD1   . TYR A 1 424 ? 16.968  12.068  33.332 1.00 26.23  ? 403  TYR A CD1   1 ? 
ATOM   3122 C CD2   . TYR A 1 424 ? 17.220  12.789  35.591 1.00 27.02  ? 403  TYR A CD2   1 ? 
ATOM   3123 C CE1   . TYR A 1 424 ? 17.192  13.357  32.881 1.00 23.91  ? 403  TYR A CE1   1 ? 
ATOM   3124 C CE2   . TYR A 1 424 ? 17.451  14.082  35.149 1.00 25.57  ? 403  TYR A CE2   1 ? 
ATOM   3125 C CZ    . TYR A 1 424 ? 17.404  14.370  33.800 1.00 23.03  ? 403  TYR A CZ    1 ? 
ATOM   3126 O OH    . TYR A 1 424 ? 17.627  15.645  33.387 1.00 21.98  ? 403  TYR A OH    1 ? 
ATOM   3127 N N     . ASP A 1 425 ? 14.464  8.305   36.850 1.00 25.94  ? 404  ASP A N     1 ? 
ATOM   3128 C CA    . ASP A 1 425 ? 14.235  6.937   37.299 1.00 24.51  ? 404  ASP A CA    1 ? 
ATOM   3129 C C     . ASP A 1 425 ? 12.995  6.368   36.623 1.00 24.16  ? 404  ASP A C     1 ? 
ATOM   3130 O O     . ASP A 1 425 ? 11.972  7.050   36.501 1.00 23.78  ? 404  ASP A O     1 ? 
ATOM   3131 C CB    . ASP A 1 425 ? 14.077  6.850   38.802 1.00 27.16  ? 404  ASP A CB    1 ? 
ATOM   3132 C CG    . ASP A 1 425 ? 15.373  6.935   39.597 1.00 28.92  ? 404  ASP A CG    1 ? 
ATOM   3133 O OD1   . ASP A 1 425 ? 16.413  6.962   38.961 1.00 28.55  ? 404  ASP A OD1   1 ? 
ATOM   3134 O OD2   . ASP A 1 425 ? 15.311  7.042   40.830 1.00 30.59  ? 404  ASP A OD2   1 ? 
ATOM   3135 N N     . ALA A 1 426 ? 13.116  5.125   36.142 1.00 22.48  ? 405  ALA A N     1 ? 
ATOM   3136 C CA    . ALA A 1 426 ? 11.986  4.456   35.527 1.00 23.30  ? 405  ALA A CA    1 ? 
ATOM   3137 C C     . ALA A 1 426 ? 10.842  4.364   36.534 1.00 21.98  ? 405  ALA A C     1 ? 
ATOM   3138 O O     . ALA A 1 426 ? 11.072  4.177   37.738 1.00 20.59  ? 405  ALA A O     1 ? 
ATOM   3139 C CB    . ALA A 1 426 ? 12.401  3.086   35.026 1.00 26.45  ? 405  ALA A CB    1 ? 
ATOM   3140 N N     . PRO A 1 427 ? 9.580   4.436   36.069 1.00 20.37  ? 406  PRO A N     1 ? 
ATOM   3141 C CA    . PRO A 1 427 ? 8.427   4.160   36.926 1.00 20.16  ? 406  PRO A CA    1 ? 
ATOM   3142 C C     . PRO A 1 427 ? 8.336   2.659   37.141 1.00 20.70  ? 406  PRO A C     1 ? 
ATOM   3143 O O     . PRO A 1 427 ? 8.998   1.907   36.425 1.00 18.01  ? 406  PRO A O     1 ? 
ATOM   3144 C CB    . PRO A 1 427 ? 7.265   4.744   36.129 1.00 20.59  ? 406  PRO A CB    1 ? 
ATOM   3145 C CG    . PRO A 1 427 ? 7.700   4.551   34.693 1.00 21.88  ? 406  PRO A CG    1 ? 
ATOM   3146 C CD    . PRO A 1 427 ? 9.186   4.704   34.674 1.00 20.79  ? 406  PRO A CD    1 ? 
ATOM   3147 N N     . LEU A 1 428 ? 7.621   2.259   38.205 1.00 20.45  ? 407  LEU A N     1 ? 
ATOM   3148 C CA    . LEU A 1 428 ? 7.424   0.863   38.562 1.00 19.04  ? 407  LEU A CA    1 ? 
ATOM   3149 C C     . LEU A 1 428 ? 6.089   0.397   37.983 1.00 17.65  ? 407  LEU A C     1 ? 
ATOM   3150 O O     . LEU A 1 428 ? 5.017   0.836   38.400 1.00 20.34  ? 407  LEU A O     1 ? 
ATOM   3151 C CB    . LEU A 1 428 ? 7.489   0.704   40.083 1.00 21.39  ? 407  LEU A CB    1 ? 
ATOM   3152 C CG    . LEU A 1 428 ? 8.770   1.242   40.732 1.00 23.89  ? 407  LEU A CG    1 ? 
ATOM   3153 C CD1   . LEU A 1 428 ? 8.659   1.219   42.257 1.00 26.74  ? 407  LEU A CD1   1 ? 
ATOM   3154 C CD2   . LEU A 1 428 ? 9.977   0.459   40.257 1.00 26.16  ? 407  LEU A CD2   1 ? 
ATOM   3155 N N     . ILE A 1 429 ? 6.172   -0.505  37.015 1.00 18.01  ? 408  ILE A N     1 ? 
ATOM   3156 C CA    . ILE A 1 429 ? 5.038   -0.933  36.224 1.00 18.05  ? 408  ILE A CA    1 ? 
ATOM   3157 C C     . ILE A 1 429 ? 4.554   -2.286  36.758 1.00 19.03  ? 408  ILE A C     1 ? 
ATOM   3158 O O     . ILE A 1 429 ? 5.295   -3.281  36.716 1.00 18.66  ? 408  ILE A O     1 ? 
ATOM   3159 C CB    . ILE A 1 429 ? 5.467   -1.030  34.755 1.00 17.56  ? 408  ILE A CB    1 ? 
ATOM   3160 C CG1   . ILE A 1 429 ? 5.979   0.324   34.219 1.00 16.86  ? 408  ILE A CG1   1 ? 
ATOM   3161 C CG2   . ILE A 1 429 ? 4.358   -1.605  33.883 1.00 18.25  ? 408  ILE A CG2   1 ? 
ATOM   3162 C CD1   . ILE A 1 429 ? 6.795   0.217   32.949 1.00 18.32  ? 408  ILE A CD1   1 ? 
ATOM   3163 N N     . ASN A 1 430 ? 3.301   -2.316  37.219 1.00 18.00  ? 409  ASN A N     1 ? 
ATOM   3164 C CA    . ASN A 1 430 ? 2.740   -3.526  37.815 1.00 20.54  ? 409  ASN A CA    1 ? 
ATOM   3165 C C     . ASN A 1 430 ? 1.331   -3.759  37.276 1.00 20.09  ? 409  ASN A C     1 ? 
ATOM   3166 O O     . ASN A 1 430 ? 0.358   -3.330  37.880 1.00 19.27  ? 409  ASN A O     1 ? 
ATOM   3167 C CB    . ASN A 1 430 ? 2.762   -3.442  39.341 1.00 20.31  ? 409  ASN A CB    1 ? 
ATOM   3168 C CG    . ASN A 1 430 ? 2.347   -4.740  39.982 1.00 19.99  ? 409  ASN A CG    1 ? 
ATOM   3169 O OD1   . ASN A 1 430 ? 2.260   -5.773  39.311 1.00 19.28  ? 409  ASN A OD1   1 ? 
ATOM   3170 N ND2   . ASN A 1 430 ? 2.104   -4.686  41.278 1.00 18.98  ? 409  ASN A ND2   1 ? 
ATOM   3171 N N     . PRO A 1 431 ? 1.155   -4.459  36.131 1.00 17.87  ? 410  PRO A N     1 ? 
ATOM   3172 C CA    . PRO A 1 431 ? -0.181  -4.784  35.622 1.00 18.29  ? 410  PRO A CA    1 ? 
ATOM   3173 C C     . PRO A 1 431 ? -0.983  -5.756  36.487 1.00 16.55  ? 410  PRO A C     1 ? 
ATOM   3174 O O     . PRO A 1 431 ? -2.198  -5.821  36.352 1.00 17.82  ? 410  PRO A O     1 ? 
ATOM   3175 C CB    . PRO A 1 431 ? 0.115   -5.359  34.226 1.00 17.26  ? 410  PRO A CB    1 ? 
ATOM   3176 C CG    . PRO A 1 431 ? 1.490   -4.787  33.896 1.00 18.66  ? 410  PRO A CG    1 ? 
ATOM   3177 C CD    . PRO A 1 431 ? 2.215   -4.916  35.229 1.00 19.35  ? 410  PRO A CD    1 ? 
ATOM   3178 N N     . ARG A 1 432 ? -0.330  -6.470  37.399 1.00 18.05  ? 411  ARG A N     1 ? 
ATOM   3179 C CA    . ARG A 1 432 ? -1.046  -7.421  38.268 1.00 18.50  ? 411  ARG A CA    1 ? 
ATOM   3180 C C     . ARG A 1 432 ? -1.760  -8.447  37.396 1.00 17.03  ? 411  ARG A C     1 ? 
ATOM   3181 O O     . ARG A 1 432 ? -2.901  -8.812  37.636 1.00 19.08  ? 411  ARG A O     1 ? 
ATOM   3182 C CB    . ARG A 1 432 ? -1.974  -6.738  39.291 1.00 19.90  ? 411  ARG A CB    1 ? 
ATOM   3183 C CG    . ARG A 1 432 ? -1.346  -5.859  40.370 1.00 24.17  ? 411  ARG A CG    1 ? 
ATOM   3184 C CD    . ARG A 1 432 ? -2.446  -5.340  41.308 1.00 29.91  ? 411  ARG A CD    1 ? 
ATOM   3185 N NE    . ARG A 1 432 ? -2.125  -4.294  42.273 1.00 39.12  ? 411  ARG A NE    1 ? 
ATOM   3186 C CZ    . ARG A 1 432 ? -2.892  -3.240  42.605 1.00 43.55  ? 411  ARG A CZ    1 ? 
ATOM   3187 N NH1   . ARG A 1 432 ? -3.988  -2.902  41.922 1.00 41.97  ? 411  ARG A NH1   1 ? 
ATOM   3188 N NH2   . ARG A 1 432 ? -2.505  -2.489  43.620 1.00 51.46  ? 411  ARG A NH2   1 ? 
ATOM   3189 N N     . TYR A 1 433 ? -1.039  -8.980  36.411 1.00 17.86  ? 412  TYR A N     1 ? 
ATOM   3190 C CA    . TYR A 1 433 ? -1.607  -9.943  35.491 1.00 18.90  ? 412  TYR A CA    1 ? 
ATOM   3191 C C     . TYR A 1 433 ? -2.114  -11.146 36.280 1.00 19.45  ? 412  TYR A C     1 ? 
ATOM   3192 O O     . TYR A 1 433 ? -1.413  -11.632 37.178 1.00 16.50  ? 412  TYR A O     1 ? 
ATOM   3193 C CB    . TYR A 1 433 ? -0.560  -10.416 34.480 1.00 21.64  ? 412  TYR A CB    1 ? 
ATOM   3194 C CG    . TYR A 1 433 ? 0.032   -9.377  33.533 1.00 20.38  ? 412  TYR A CG    1 ? 
ATOM   3195 C CD1   . TYR A 1 433 ? -0.717  -8.790  32.516 1.00 20.21  ? 412  TYR A CD1   1 ? 
ATOM   3196 C CD2   . TYR A 1 433 ? 1.384   -9.073  33.578 1.00 19.60  ? 412  TYR A CD2   1 ? 
ATOM   3197 C CE1   . TYR A 1 433 ? -0.158  -7.864  31.646 1.00 17.51  ? 412  TYR A CE1   1 ? 
ATOM   3198 C CE2   . TYR A 1 433 ? 1.965   -8.193  32.680 1.00 17.64  ? 412  TYR A CE2   1 ? 
ATOM   3199 C CZ    . TYR A 1 433 ? 1.185   -7.553  31.731 1.00 16.69  ? 412  TYR A CZ    1 ? 
ATOM   3200 O OH    . TYR A 1 433 ? 1.775   -6.687  30.824 1.00 17.41  ? 412  TYR A OH    1 ? 
ATOM   3201 N N     . PHE A 1 434 ? -3.320  -11.605 35.909 1.00 19.91  ? 413  PHE A N     1 ? 
ATOM   3202 C CA    . PHE A 1 434 ? -3.988  -12.758 36.528 1.00 21.25  ? 413  PHE A CA    1 ? 
ATOM   3203 C C     . PHE A 1 434 ? -4.256  -12.552 38.031 1.00 23.11  ? 413  PHE A C     1 ? 
ATOM   3204 O O     . PHE A 1 434 ? -4.434  -13.524 38.778 1.00 25.69  ? 413  PHE A O     1 ? 
ATOM   3205 C CB    . PHE A 1 434 ? -3.199  -14.054 36.288 1.00 19.55  ? 413  PHE A CB    1 ? 
ATOM   3206 C CG    . PHE A 1 434 ? -3.181  -14.508 34.838 1.00 19.88  ? 413  PHE A CG    1 ? 
ATOM   3207 C CD1   . PHE A 1 434 ? -4.366  -14.693 34.143 1.00 19.12  ? 413  PHE A CD1   1 ? 
ATOM   3208 C CD2   . PHE A 1 434 ? -1.982  -14.754 34.180 1.00 19.19  ? 413  PHE A CD2   1 ? 
ATOM   3209 C CE1   . PHE A 1 434 ? -4.351  -15.076 32.815 1.00 20.22  ? 413  PHE A CE1   1 ? 
ATOM   3210 C CE2   . PHE A 1 434 ? -1.965  -15.176 32.861 1.00 19.74  ? 413  PHE A CE2   1 ? 
ATOM   3211 C CZ    . PHE A 1 434 ? -3.151  -15.313 32.172 1.00 20.86  ? 413  PHE A CZ    1 ? 
ATOM   3212 N N     . SER A 1 435 ? -4.387  -11.294 38.477 1.00 23.44  ? 414  SER A N     1 ? 
ATOM   3213 C CA    . SER A 1 435 ? -4.737  -11.029 39.860 1.00 19.23  ? 414  SER A CA    1 ? 
ATOM   3214 C C     . SER A 1 435 ? -6.240  -11.238 40.052 1.00 21.41  ? 414  SER A C     1 ? 
ATOM   3215 O O     . SER A 1 435 ? -6.657  -11.776 41.082 1.00 22.94  ? 414  SER A O     1 ? 
ATOM   3216 C CB    . SER A 1 435 ? -4.278  -9.656  40.291 1.00 20.97  ? 414  SER A CB    1 ? 
ATOM   3217 O OG    . SER A 1 435 ? -4.913  -8.643  39.521 1.00 20.62  ? 414  SER A OG    1 ? 
ATOM   3218 N N     . ASP A 1 436 ? -7.042  -10.900 39.020 1.00 18.76  ? 415  ASP A N     1 ? 
ATOM   3219 C CA    . ASP A 1 436 ? -8.429  -11.280 38.966 1.00 22.02  ? 415  ASP A CA    1 ? 
ATOM   3220 C C     . ASP A 1 436 ? -8.536  -12.715 38.475 1.00 20.88  ? 415  ASP A C     1 ? 
ATOM   3221 O O     . ASP A 1 436 ? -8.100  -13.028 37.370 1.00 21.54  ? 415  ASP A O     1 ? 
ATOM   3222 C CB    . ASP A 1 436 ? -9.292  -10.331 38.152 1.00 24.21  ? 415  ASP A CB    1 ? 
ATOM   3223 C CG    . ASP A 1 436 ? -10.785 -10.495 38.391 1.00 24.87  ? 415  ASP A CG    1 ? 
ATOM   3224 O OD1   . ASP A 1 436 ? -11.312 -11.576 38.045 1.00 26.66  ? 415  ASP A OD1   1 ? 
ATOM   3225 O OD2   . ASP A 1 436 ? -11.385 -9.563  38.957 1.00 25.13  ? 415  ASP A OD2   1 ? 
ATOM   3226 N N     . SER A 1 437 ? -9.174  -13.558 39.303 1.00 22.50  ? 416  SER A N     1 ? 
ATOM   3227 C CA    . SER A 1 437 ? -9.243  -15.007 39.092 1.00 21.76  ? 416  SER A CA    1 ? 
ATOM   3228 C C     . SER A 1 437 ? -10.001 -15.373 37.824 1.00 21.34  ? 416  SER A C     1 ? 
ATOM   3229 O O     . SER A 1 437 ? -9.753  -16.429 37.245 1.00 23.06  ? 416  SER A O     1 ? 
ATOM   3230 C CB    . SER A 1 437 ? -9.871  -15.700 40.306 1.00 23.18  ? 416  SER A CB    1 ? 
ATOM   3231 O OG    . SER A 1 437 ? -9.129  -15.413 41.490 1.00 22.25  ? 416  SER A OG    1 ? 
ATOM   3232 N N     . SER A 1 438 ? -10.932 -14.518 37.374 1.00 20.77  ? 417  SER A N     1 ? 
ATOM   3233 C CA    . SER A 1 438 ? -11.663 -14.814 36.157 1.00 22.15  ? 417  SER A CA    1 ? 
ATOM   3234 C C     . SER A 1 438 ? -10.765 -14.825 34.910 1.00 21.07  ? 417  SER A C     1 ? 
ATOM   3235 O O     . SER A 1 438 ? -11.122 -15.429 33.913 1.00 21.21  ? 417  SER A O     1 ? 
ATOM   3236 C CB    . SER A 1 438 ? -12.809 -13.872 35.965 1.00 26.30  ? 417  SER A CB    1 ? 
ATOM   3237 O OG    . SER A 1 438 ? -12.374 -12.599 35.558 1.00 35.00  ? 417  SER A OG    1 ? 
ATOM   3238 N N     . ASP A 1 439 ? -9.620  -14.136 34.938 1.00 20.21  ? 418  ASP A N     1 ? 
ATOM   3239 C CA    . ASP A 1 439 ? -8.750  -14.041 33.774 1.00 20.22  ? 418  ASP A CA    1 ? 
ATOM   3240 C C     . ASP A 1 439 ? -8.209  -15.421 33.393 1.00 20.37  ? 418  ASP A C     1 ? 
ATOM   3241 O O     . ASP A 1 439 ? -8.318  -15.825 32.238 1.00 21.61  ? 418  ASP A O     1 ? 
ATOM   3242 C CB    . ASP A 1 439 ? -7.678  -12.960 33.942 1.00 19.77  ? 418  ASP A CB    1 ? 
ATOM   3243 C CG    . ASP A 1 439 ? -8.184  -11.513 34.033 1.00 20.81  ? 418  ASP A CG    1 ? 
ATOM   3244 O OD1   . ASP A 1 439 ? -9.376  -11.318 33.804 1.00 19.88  ? 418  ASP A OD1   1 ? 
ATOM   3245 O OD2   . ASP A 1 439 ? -7.361  -10.578 34.339 1.00 22.25  ? 418  ASP A OD2   1 ? 
ATOM   3246 N N     . MET A 1 440 ? -7.581  -16.141 34.332 1.00 22.14  ? 419  MET A N     1 ? 
ATOM   3247 C CA    . MET A 1 440 ? -7.082  -17.487 34.042 1.00 21.25  ? 419  MET A CA    1 ? 
ATOM   3248 C C     . MET A 1 440 ? -8.212  -18.470 33.700 1.00 21.45  ? 419  MET A C     1 ? 
ATOM   3249 O O     . MET A 1 440 ? -8.087  -19.268 32.770 1.00 19.50  ? 419  MET A O     1 ? 
ATOM   3250 C CB    . MET A 1 440 ? -6.251  -18.042 35.209 1.00 21.39  ? 419  MET A CB    1 ? 
ATOM   3251 C CG    . MET A 1 440 ? -5.597  -19.392 34.925 1.00 21.99  ? 419  MET A CG    1 ? 
ATOM   3252 S SD    . MET A 1 440 ? -4.523  -19.434 33.465 1.00 22.68  ? 419  MET A SD    1 ? 
ATOM   3253 C CE    . MET A 1 440 ? -3.177  -18.414 34.102 1.00 22.06  ? 419  MET A CE    1 ? 
ATOM   3254 N N     . GLU A 1 441 ? -9.330  -18.386 34.412 1.00 24.28  ? 420  GLU A N     1 ? 
ATOM   3255 C CA    . GLU A 1 441 ? -10.502 -19.235 34.153 1.00 25.74  ? 420  GLU A CA    1 ? 
ATOM   3256 C C     . GLU A 1 441 ? -10.889 -19.135 32.678 1.00 25.62  ? 420  GLU A C     1 ? 
ATOM   3257 O O     . GLU A 1 441 ? -10.947 -20.144 31.981 1.00 22.14  ? 420  GLU A O     1 ? 
ATOM   3258 C CB    . GLU A 1 441 ? -11.600 -18.810 35.135 1.00 24.60  ? 420  GLU A CB    1 ? 
ATOM   3259 C CG    . GLU A 1 441 ? -12.997 -19.401 34.961 1.00 24.92  ? 420  GLU A CG    1 ? 
ATOM   3260 C CD    . GLU A 1 441 ? -13.868 -19.198 36.184 1.00 29.06  ? 420  GLU A CD    1 ? 
ATOM   3261 O OE1   . GLU A 1 441 ? -14.072 -20.216 36.908 1.00 27.96  ? 420  GLU A OE1   1 ? 
ATOM   3262 O OE2   . GLU A 1 441 ? -14.358 -18.053 36.426 1.00 25.89  ? 420  GLU A OE2   1 ? 
ATOM   3263 N N     . ARG A 1 442 ? -11.053 -17.903 32.184 1.00 26.58  ? 421  ARG A N     1 ? 
ATOM   3264 C CA    . ARG A 1 442 ? -11.469 -17.677 30.801 1.00 25.11  ? 421  ARG A CA    1 ? 
ATOM   3265 C C     . ARG A 1 442 ? -10.353 -18.052 29.823 1.00 23.18  ? 421  ARG A C     1 ? 
ATOM   3266 O O     . ARG A 1 442 ? -10.607 -18.694 28.807 1.00 22.51  ? 421  ARG A O     1 ? 
ATOM   3267 C CB    . ARG A 1 442 ? -11.969 -16.244 30.612 1.00 24.49  ? 421  ARG A CB    1 ? 
ATOM   3268 C CG    . ARG A 1 442 ? -13.266 -15.942 31.357 1.00 24.36  ? 421  ARG A CG    1 ? 
ATOM   3269 C CD    . ARG A 1 442 ? -13.673 -14.462 31.134 1.00 27.59  ? 421  ARG A CD    1 ? 
ATOM   3270 N NE    . ARG A 1 442 ? -12.767 -13.546 31.847 1.00 27.40  ? 421  ARG A NE    1 ? 
ATOM   3271 C CZ    . ARG A 1 442 ? -12.567 -12.266 31.531 1.00 27.04  ? 421  ARG A CZ    1 ? 
ATOM   3272 N NH1   . ARG A 1 442 ? -13.122 -11.739 30.452 1.00 24.51  ? 421  ARG A NH1   1 ? 
ATOM   3273 N NH2   . ARG A 1 442 ? -11.798 -11.508 32.289 1.00 26.18  ? 421  ARG A NH2   1 ? 
ATOM   3274 N N     . PHE A 1 443 ? -9.097  -17.712 30.149 1.00 24.51  ? 422  PHE A N     1 ? 
ATOM   3275 C CA    . PHE A 1 443 ? -7.980  -17.959 29.251 1.00 21.22  ? 422  PHE A CA    1 ? 
ATOM   3276 C C     . PHE A 1 443 ? -7.852  -19.456 28.938 1.00 22.70  ? 422  PHE A C     1 ? 
ATOM   3277 O O     . PHE A 1 443 ? -7.616  -19.820 27.797 1.00 21.45  ? 422  PHE A O     1 ? 
ATOM   3278 C CB    . PHE A 1 443 ? -6.684  -17.384 29.837 1.00 22.06  ? 422  PHE A CB    1 ? 
ATOM   3279 C CG    . PHE A 1 443 ? -5.786  -16.675 28.825 1.00 20.09  ? 422  PHE A CG    1 ? 
ATOM   3280 C CD1   . PHE A 1 443 ? -5.481  -17.255 27.591 1.00 21.15  ? 422  PHE A CD1   1 ? 
ATOM   3281 C CD2   . PHE A 1 443 ? -5.298  -15.396 29.084 1.00 19.29  ? 422  PHE A CD2   1 ? 
ATOM   3282 C CE1   . PHE A 1 443 ? -4.687  -16.585 26.670 1.00 20.80  ? 422  PHE A CE1   1 ? 
ATOM   3283 C CE2   . PHE A 1 443 ? -4.529  -14.729 28.166 1.00 18.43  ? 422  PHE A CE2   1 ? 
ATOM   3284 C CZ    . PHE A 1 443 ? -4.208  -15.315 26.968 1.00 20.69  ? 422  PHE A CZ    1 ? 
ATOM   3285 N N     . ILE A 1 444 ? -7.995  -20.330 29.946 1.00 23.54  ? 423  ILE A N     1 ? 
ATOM   3286 C CA    . ILE A 1 444 ? -7.867  -21.757 29.702 1.00 26.96  ? 423  ILE A CA    1 ? 
ATOM   3287 C C     . ILE A 1 444 ? -8.953  -22.206 28.723 1.00 25.66  ? 423  ILE A C     1 ? 
ATOM   3288 O O     . ILE A 1 444 ? -8.657  -22.960 27.802 1.00 27.61  ? 423  ILE A O     1 ? 
ATOM   3289 C CB    . ILE A 1 444 ? -7.891  -22.576 30.996 1.00 24.79  ? 423  ILE A CB    1 ? 
ATOM   3290 C CG1   . ILE A 1 444 ? -6.684  -22.274 31.871 1.00 24.11  ? 423  ILE A CG1   1 ? 
ATOM   3291 C CG2   . ILE A 1 444 ? -7.988  -24.079 30.685 1.00 26.91  ? 423  ILE A CG2   1 ? 
ATOM   3292 C CD1   . ILE A 1 444 ? -6.852  -22.669 33.331 1.00 23.96  ? 423  ILE A CD1   1 ? 
ATOM   3293 N N     . LYS A 1 445 ? -10.174 -21.716 28.910 1.00 24.39  ? 424  LYS A N     1 ? 
ATOM   3294 C CA    . LYS A 1 445 ? -11.284 -22.015 28.009 1.00 30.12  ? 424  LYS A CA    1 ? 
ATOM   3295 C C     . LYS A 1 445 ? -11.005 -21.514 26.595 1.00 28.90  ? 424  LYS A C     1 ? 
ATOM   3296 O O     . LYS A 1 445 ? -11.322 -22.175 25.604 1.00 26.63  ? 424  LYS A O     1 ? 
ATOM   3297 C CB    . LYS A 1 445 ? -12.601 -21.430 28.536 1.00 32.28  ? 424  LYS A CB    1 ? 
ATOM   3298 C CG    . LYS A 1 445 ? -13.183 -22.233 29.708 1.00 35.56  ? 424  LYS A CG    1 ? 
ATOM   3299 C CD    . LYS A 1 445 ? -14.266 -21.472 30.479 1.00 40.71  ? 424  LYS A CD    1 ? 
ATOM   3300 C CE    . LYS A 1 445 ? -14.627 -22.069 31.807 1.00 42.00  ? 424  LYS A CE    1 ? 
ATOM   3301 N NZ    . LYS A 1 445 ? -15.578 -21.214 32.521 1.00 43.39  ? 424  LYS A NZ    1 ? 
ATOM   3302 N N     . GLY A 1 446 ? -10.387 -20.330 26.480 1.00 27.55  ? 425  GLY A N     1 ? 
ATOM   3303 C CA    . GLY A 1 446 ? -10.070 -19.791 25.167 1.00 22.43  ? 425  GLY A CA    1 ? 
ATOM   3304 C C     . GLY A 1 446 ? -9.074  -20.642 24.392 1.00 23.64  ? 425  GLY A C     1 ? 
ATOM   3305 O O     . GLY A 1 446 ? -9.155  -20.750 23.167 1.00 24.12  ? 425  GLY A O     1 ? 
ATOM   3306 N N     . VAL A 1 447 ? -8.080  -21.189 25.096 1.00 24.68  ? 426  VAL A N     1 ? 
ATOM   3307 C CA    . VAL A 1 447 ? -7.100  -22.059 24.478 1.00 23.66  ? 426  VAL A CA    1 ? 
ATOM   3308 C C     . VAL A 1 447 ? -7.798  -23.314 23.922 1.00 26.96  ? 426  VAL A C     1 ? 
ATOM   3309 O O     . VAL A 1 447 ? -7.533  -23.729 22.801 1.00 27.70  ? 426  VAL A O     1 ? 
ATOM   3310 C CB    . VAL A 1 447 ? -6.034  -22.425 25.528 1.00 25.86  ? 426  VAL A CB    1 ? 
ATOM   3311 C CG1   . VAL A 1 447 ? -5.146  -23.583 25.096 1.00 26.08  ? 426  VAL A CG1   1 ? 
ATOM   3312 C CG2   . VAL A 1 447 ? -5.180  -21.228 25.911 1.00 27.82  ? 426  VAL A CG2   1 ? 
ATOM   3313 N N     . ARG A 1 448 ? -8.675  -23.918 24.716 1.00 26.58  ? 427  ARG A N     1 ? 
ATOM   3314 C CA    . ARG A 1 448 ? -9.330  -25.149 24.308 1.00 28.46  ? 427  ARG A CA    1 ? 
ATOM   3315 C C     . ARG A 1 448 ? -10.253 -24.875 23.135 1.00 30.83  ? 427  ARG A C     1 ? 
ATOM   3316 O O     . ARG A 1 448 ? -10.262 -25.666 22.201 1.00 31.47  ? 427  ARG A O     1 ? 
ATOM   3317 C CB    . ARG A 1 448 ? -10.057 -25.775 25.492 1.00 32.56  ? 427  ARG A CB    1 ? 
ATOM   3318 C CG    . ARG A 1 448 ? -9.068  -26.352 26.490 1.00 36.43  ? 427  ARG A CG    1 ? 
ATOM   3319 C CD    . ARG A 1 448 ? -9.601  -27.649 27.016 1.00 42.75  ? 427  ARG A CD    1 ? 
ATOM   3320 N NE    . ARG A 1 448 ? -8.833  -28.019 28.202 1.00 48.19  ? 427  ARG A NE    1 ? 
ATOM   3321 C CZ    . ARG A 1 448 ? -7.804  -28.847 28.217 1.00 49.84  ? 427  ARG A CZ    1 ? 
ATOM   3322 N NH1   . ARG A 1 448 ? -7.352  -29.379 27.099 1.00 50.12  ? 427  ARG A NH1   1 ? 
ATOM   3323 N NH2   . ARG A 1 448 ? -7.221  -29.118 29.371 1.00 55.04  ? 427  ARG A NH2   1 ? 
ATOM   3324 N N     . TYR A 1 449 ? -10.958 -23.734 23.173 1.00 28.04  ? 428  TYR A N     1 ? 
ATOM   3325 C CA    . TYR A 1 449 ? -11.825 -23.313 22.082 1.00 27.46  ? 428  TYR A CA    1 ? 
ATOM   3326 C C     . TYR A 1 449 ? -11.023 -23.218 20.797 1.00 30.11  ? 428  TYR A C     1 ? 
ATOM   3327 O O     . TYR A 1 449 ? -11.406 -23.798 19.770 1.00 30.42  ? 428  TYR A O     1 ? 
ATOM   3328 C CB    . TYR A 1 449 ? -12.554 -22.009 22.407 1.00 28.65  ? 428  TYR A CB    1 ? 
ATOM   3329 C CG    . TYR A 1 449 ? -13.512 -21.517 21.322 1.00 31.21  ? 428  TYR A CG    1 ? 
ATOM   3330 C CD1   . TYR A 1 449 ? -14.821 -21.988 21.217 1.00 33.01  ? 428  TYR A CD1   1 ? 
ATOM   3331 C CD2   . TYR A 1 449 ? -13.107 -20.545 20.413 1.00 35.49  ? 428  TYR A CD2   1 ? 
ATOM   3332 C CE1   . TYR A 1 449 ? -15.685 -21.523 20.232 1.00 31.18  ? 428  TYR A CE1   1 ? 
ATOM   3333 C CE2   . TYR A 1 449 ? -13.969 -20.049 19.447 1.00 35.78  ? 428  TYR A CE2   1 ? 
ATOM   3334 C CZ    . TYR A 1 449 ? -15.252 -20.558 19.340 1.00 35.95  ? 428  TYR A CZ    1 ? 
ATOM   3335 O OH    . TYR A 1 449 ? -16.062 -20.049 18.365 1.00 32.31  ? 428  TYR A OH    1 ? 
ATOM   3336 N N     . THR A 1 450 ? -9.914  -22.472 20.869 1.00 26.24  ? 429  THR A N     1 ? 
ATOM   3337 C CA    . THR A 1 450 ? -9.044  -22.254 19.734 1.00 25.89  ? 429  THR A CA    1 ? 
ATOM   3338 C C     . THR A 1 450 ? -8.514  -23.575 19.172 1.00 27.30  ? 429  THR A C     1 ? 
ATOM   3339 O O     . THR A 1 450 ? -8.345  -23.692 17.964 1.00 28.81  ? 429  THR A O     1 ? 
ATOM   3340 C CB    . THR A 1 450 ? -7.891  -21.338 20.152 1.00 26.80  ? 429  THR A CB    1 ? 
ATOM   3341 O OG1   . THR A 1 450 ? -8.453  -20.126 20.667 1.00 27.35  ? 429  THR A OG1   1 ? 
ATOM   3342 C CG2   . THR A 1 450 ? -6.989  -21.034 18.979 1.00 27.00  ? 429  THR A CG2   1 ? 
ATOM   3343 N N     . GLN A 1 451 ? -8.181  -24.536 20.038 1.00 29.66  ? 430  GLN A N     1 ? 
ATOM   3344 C CA    . GLN A 1 451 ? -7.554  -25.778 19.586 1.00 31.98  ? 430  GLN A CA    1 ? 
ATOM   3345 C C     . GLN A 1 451 ? -8.471  -26.598 18.662 1.00 33.67  ? 430  GLN A C     1 ? 
ATOM   3346 O O     . GLN A 1 451 ? -7.988  -27.471 17.937 1.00 35.64  ? 430  GLN A O     1 ? 
ATOM   3347 C CB    . GLN A 1 451 ? -7.169  -26.663 20.771 1.00 31.60  ? 430  GLN A CB    1 ? 
ATOM   3348 C CG    . GLN A 1 451 ? -5.937  -26.174 21.523 1.00 33.31  ? 430  GLN A CG    1 ? 
ATOM   3349 C CD    . GLN A 1 451 ? -5.665  -26.941 22.792 1.00 31.40  ? 430  GLN A CD    1 ? 
ATOM   3350 O OE1   . GLN A 1 451 ? -6.555  -27.174 23.614 1.00 35.33  ? 430  GLN A OE1   1 ? 
ATOM   3351 N NE2   . GLN A 1 451 ? -4.416  -27.330 22.969 1.00 40.27  ? 430  GLN A NE2   1 ? 
ATOM   3352 N N     . LYS A 1 452 ? -9.787  -26.360 18.727 1.00 33.42  ? 431  LYS A N     1 ? 
ATOM   3353 C CA    . LYS A 1 452 ? -10.734 -26.977 17.803 1.00 34.17  ? 431  LYS A CA    1 ? 
ATOM   3354 C C     . LYS A 1 452 ? -10.327 -26.746 16.347 1.00 39.74  ? 431  LYS A C     1 ? 
ATOM   3355 O O     . LYS A 1 452 ? -10.685 -27.527 15.462 1.00 38.29  ? 431  LYS A O     1 ? 
ATOM   3356 C CB    . LYS A 1 452 ? -12.152 -26.451 18.040 1.00 36.58  ? 431  LYS A CB    1 ? 
ATOM   3357 C CG    . LYS A 1 452 ? -12.726 -26.813 19.407 1.00 39.23  ? 431  LYS A CG    1 ? 
ATOM   3358 C CD    . LYS A 1 452 ? -14.223 -26.604 19.600 1.00 38.86  ? 431  LYS A CD    1 ? 
ATOM   3359 C CE    . LYS A 1 452 ? -14.701 -25.298 19.062 1.00 42.43  ? 431  LYS A CE    1 ? 
ATOM   3360 N NZ    . LYS A 1 452 ? -16.077 -25.060 19.488 1.00 45.10  ? 431  LYS A NZ    1 ? 
ATOM   3361 N N     . ILE A 1 453 ? -9.544  -25.694 16.079 1.00 33.14  ? 432  ILE A N     1 ? 
ATOM   3362 C CA    . ILE A 1 453 ? -9.272  -25.343 14.708 1.00 30.68  ? 432  ILE A CA    1 ? 
ATOM   3363 C C     . ILE A 1 453 ? -8.391  -26.416 14.069 1.00 35.14  ? 432  ILE A C     1 ? 
ATOM   3364 O O     . ILE A 1 453 ? -8.367  -26.522 12.846 1.00 32.45  ? 432  ILE A O     1 ? 
ATOM   3365 C CB    . ILE A 1 453 ? -8.620  -23.953 14.614 1.00 30.02  ? 432  ILE A CB    1 ? 
ATOM   3366 C CG1   . ILE A 1 453 ? -8.954  -23.272 13.287 1.00 32.53  ? 432  ILE A CG1   1 ? 
ATOM   3367 C CG2   . ILE A 1 453 ? -7.116  -24.053 14.868 1.00 28.43  ? 432  ILE A CG2   1 ? 
ATOM   3368 C CD1   . ILE A 1 453 ? -8.173  -21.996 13.023 1.00 33.60  ? 432  ILE A CD1   1 ? 
ATOM   3369 N N     . THR A 1 454 ? -7.623  -27.155 14.890 1.00 32.38  ? 433  THR A N     1 ? 
ATOM   3370 C CA    . THR A 1 454 ? -6.708  -28.164 14.373 1.00 35.12  ? 433  THR A CA    1 ? 
ATOM   3371 C C     . THR A 1 454 ? -7.487  -29.344 13.770 1.00 39.66  ? 433  THR A C     1 ? 
ATOM   3372 O O     . THR A 1 454 ? -6.887  -30.172 13.094 1.00 40.24  ? 433  THR A O     1 ? 
ATOM   3373 C CB    . THR A 1 454 ? -5.776  -28.678 15.476 1.00 35.94  ? 433  THR A CB    1 ? 
ATOM   3374 O OG1   . THR A 1 454 ? -6.608  -29.322 16.428 1.00 30.65  ? 433  THR A OG1   1 ? 
ATOM   3375 C CG2   . THR A 1 454 ? -4.967  -27.590 16.162 1.00 41.82  ? 433  THR A CG2   1 ? 
ATOM   3376 N N     . LYS A 1 455 ? -8.786  -29.454 14.078 1.00 39.23  ? 434  LYS A N     1 ? 
ATOM   3377 C CA    . LYS A 1 455 ? -9.619  -30.560 13.623 1.00 45.97  ? 434  LYS A CA    1 ? 
ATOM   3378 C C     . LYS A 1 455 ? -10.216 -30.296 12.238 1.00 45.62  ? 434  LYS A C     1 ? 
ATOM   3379 O O     . LYS A 1 455 ? -10.858 -31.180 11.687 1.00 54.32  ? 434  LYS A O     1 ? 
ATOM   3380 C CB    . LYS A 1 455 ? -10.776 -30.792 14.605 1.00 45.66  ? 434  LYS A CB    1 ? 
ATOM   3381 C CG    . LYS A 1 455 ? -10.554 -31.782 15.739 1.00 50.19  ? 434  LYS A CG    1 ? 
ATOM   3382 C CD    . LYS A 1 455 ? -9.141  -31.816 16.302 1.00 52.47  ? 434  LYS A CD    1 ? 
ATOM   3383 C CE    . LYS A 1 455 ? -8.911  -33.005 17.171 1.00 55.05  ? 434  LYS A CE    1 ? 
ATOM   3384 N NZ    . LYS A 1 455 ? -7.505  -33.057 17.569 1.00 58.03  ? 434  LYS A NZ    1 ? 
ATOM   3385 N N     . THR A 1 456 ? -10.031 -29.093 11.684 1.00 42.33  ? 435  THR A N     1 ? 
ATOM   3386 C CA    . THR A 1 456 ? -10.734 -28.720 10.470 1.00 45.25  ? 435  THR A CA    1 ? 
ATOM   3387 C C     . THR A 1 456 ? -10.074 -29.408 9.277  1.00 43.56  ? 435  THR A C     1 ? 
ATOM   3388 O O     . THR A 1 456 ? -8.913  -29.806 9.332  1.00 34.80  ? 435  THR A O     1 ? 
ATOM   3389 C CB    . THR A 1 456 ? -10.754 -27.201 10.300 1.00 44.41  ? 435  THR A CB    1 ? 
ATOM   3390 O OG1   . THR A 1 456 ? -9.393  -26.816 10.176 1.00 42.03  ? 435  THR A OG1   1 ? 
ATOM   3391 C CG2   . THR A 1 456 ? -11.456 -26.485 11.443 1.00 45.30  ? 435  THR A CG2   1 ? 
ATOM   3392 N N     . GLU A 1 457 ? -10.819 -29.530 8.180  1.00 45.43  ? 436  GLU A N     1 ? 
ATOM   3393 C CA    . GLU A 1 457 ? -10.302 -30.179 6.987  1.00 46.40  ? 436  GLU A CA    1 ? 
ATOM   3394 C C     . GLU A 1 457 ? -9.106  -29.382 6.468  1.00 43.40  ? 436  GLU A C     1 ? 
ATOM   3395 O O     . GLU A 1 457 ? -8.128  -29.969 6.015  1.00 34.67  ? 436  GLU A O     1 ? 
ATOM   3396 C CB    . GLU A 1 457 ? -11.435 -30.320 5.967  1.00 61.09  ? 436  GLU A CB    1 ? 
ATOM   3397 C CG    . GLU A 1 457 ? -11.224 -31.457 4.972  1.00 70.97  ? 436  GLU A CG    1 ? 
ATOM   3398 C CD    . GLU A 1 457 ? -12.214 -31.442 3.820  1.00 81.28  ? 436  GLU A CD    1 ? 
ATOM   3399 O OE1   . GLU A 1 457 ? -11.741 -31.321 2.667  1.00 85.57  ? 436  GLU A OE1   1 ? 
ATOM   3400 O OE2   . GLU A 1 457 ? -13.441 -31.538 4.074  1.00 84.47  ? 436  GLU A OE2   1 ? 
ATOM   3401 N N     . SER A 1 458 ? -9.159  -28.043 6.579  1.00 39.74  ? 437  SER A N     1 ? 
ATOM   3402 C CA    . SER A 1 458 ? -8.055  -27.194 6.163  1.00 38.31  ? 437  SER A CA    1 ? 
ATOM   3403 C C     . SER A 1 458 ? -6.774  -27.476 6.952  1.00 33.62  ? 437  SER A C     1 ? 
ATOM   3404 O O     . SER A 1 458 ? -5.705  -27.568 6.348  1.00 38.50  ? 437  SER A O     1 ? 
ATOM   3405 C CB    . SER A 1 458 ? -8.422  -25.733 6.264  1.00 47.38  ? 437  SER A CB    1 ? 
ATOM   3406 O OG    . SER A 1 458 ? -9.468  -25.418 5.358  1.00 52.41  ? 437  SER A OG    1 ? 
ATOM   3407 N N     . LEU A 1 459 ? -6.863  -27.567 8.291  1.00 36.79  ? 438  LEU A N     1 ? 
ATOM   3408 C CA    . LEU A 1 459 ? -5.670  -27.457 9.126  1.00 36.58  ? 438  LEU A CA    1 ? 
ATOM   3409 C C     . LEU A 1 459 ? -5.218  -28.802 9.709  1.00 38.64  ? 438  LEU A C     1 ? 
ATOM   3410 O O     . LEU A 1 459 ? -4.039  -28.953 10.001 1.00 38.06  ? 438  LEU A O     1 ? 
ATOM   3411 C CB    . LEU A 1 459 ? -5.829  -26.374 10.204 1.00 37.21  ? 438  LEU A CB    1 ? 
ATOM   3412 C CG    . LEU A 1 459 ? -5.880  -24.932 9.682  1.00 35.55  ? 438  LEU A CG    1 ? 
ATOM   3413 C CD1   . LEU A 1 459 ? -6.142  -23.906 10.775 1.00 38.35  ? 438  LEU A CD1   1 ? 
ATOM   3414 C CD2   . LEU A 1 459 ? -4.611  -24.541 8.942  1.00 31.46  ? 438  LEU A CD2   1 ? 
ATOM   3415 N N     . GLU A 1 460 ? -6.108  -29.799 9.839  1.00 41.24  ? 439  GLU A N     1 ? 
ATOM   3416 C CA    . GLU A 1 460 ? -5.710  -31.121 10.311 1.00 49.03  ? 439  GLU A CA    1 ? 
ATOM   3417 C C     . GLU A 1 460 ? -4.519  -31.680 9.514  1.00 43.28  ? 439  GLU A C     1 ? 
ATOM   3418 O O     . GLU A 1 460 ? -3.566  -32.181 10.106 1.00 43.94  ? 439  GLU A O     1 ? 
ATOM   3419 C CB    . GLU A 1 460 ? -6.952  -32.014 10.383 1.00 55.66  ? 439  GLU A CB    1 ? 
ATOM   3420 C CG    . GLU A 1 460 ? -6.655  -33.441 10.835 1.00 64.10  ? 439  GLU A CG    1 ? 
ATOM   3421 C CD    . GLU A 1 460 ? -6.480  -34.396 9.671  1.00 66.54  ? 439  GLU A CD    1 ? 
ATOM   3422 O OE1   . GLU A 1 460 ? -7.348  -35.276 9.538  1.00 75.98  ? 439  GLU A OE1   1 ? 
ATOM   3423 O OE2   . GLU A 1 460 ? -5.511  -34.259 8.900  1.00 69.13  ? 439  GLU A OE2   1 ? 
ATOM   3424 N N     . PRO A 1 461 ? -4.470  -31.582 8.165  1.00 47.65  ? 440  PRO A N     1 ? 
ATOM   3425 C CA    . PRO A 1 461 ? -3.280  -31.994 7.407  1.00 46.83  ? 440  PRO A CA    1 ? 
ATOM   3426 C C     . PRO A 1 461 ? -1.948  -31.342 7.786  1.00 46.38  ? 440  PRO A C     1 ? 
ATOM   3427 O O     . PRO A 1 461 ? -0.889  -31.864 7.433  1.00 38.39  ? 440  PRO A O     1 ? 
ATOM   3428 C CB    . PRO A 1 461 ? -3.643  -31.666 5.935  1.00 48.35  ? 440  PRO A CB    1 ? 
ATOM   3429 C CG    . PRO A 1 461 ? -5.153  -31.669 5.922  1.00 48.74  ? 440  PRO A CG    1 ? 
ATOM   3430 C CD    . PRO A 1 461 ? -5.560  -31.115 7.290  1.00 50.82  ? 440  PRO A CD    1 ? 
ATOM   3431 N N     . TYR A 1 462 ? -1.992  -30.186 8.468  1.00 40.64  ? 441  TYR A N     1 ? 
ATOM   3432 C CA    . TYR A 1 462 ? -0.783  -29.455 8.824  1.00 37.67  ? 441  TYR A CA    1 ? 
ATOM   3433 C C     . TYR A 1 462 ? -0.476  -29.529 10.320 1.00 36.75  ? 441  TYR A C     1 ? 
ATOM   3434 O O     . TYR A 1 462 ? 0.407   -28.802 10.779 1.00 34.82  ? 441  TYR A O     1 ? 
ATOM   3435 C CB    . TYR A 1 462 ? -0.978  -27.994 8.408  1.00 34.73  ? 441  TYR A CB    1 ? 
ATOM   3436 C CG    . TYR A 1 462 ? -1.110  -27.802 6.910  1.00 38.08  ? 441  TYR A CG    1 ? 
ATOM   3437 C CD1   . TYR A 1 462 ? 0.022   -27.714 6.107  1.00 42.75  ? 441  TYR A CD1   1 ? 
ATOM   3438 C CD2   . TYR A 1 462 ? -2.355  -27.715 6.297  1.00 40.22  ? 441  TYR A CD2   1 ? 
ATOM   3439 C CE1   . TYR A 1 462 ? -0.078  -27.539 4.738  1.00 45.63  ? 441  TYR A CE1   1 ? 
ATOM   3440 C CE2   . TYR A 1 462 ? -2.467  -27.550 4.925  1.00 40.80  ? 441  TYR A CE2   1 ? 
ATOM   3441 C CZ    . TYR A 1 462 ? -1.329  -27.461 4.145  1.00 41.17  ? 441  TYR A CZ    1 ? 
ATOM   3442 O OH    . TYR A 1 462 ? -1.372  -27.308 2.791  1.00 39.48  ? 441  TYR A OH    1 ? 
ATOM   3443 N N     . THR A 1 463 ? -1.220  -30.357 11.070 1.00 35.01  ? 442  THR A N     1 ? 
ATOM   3444 C CA    . THR A 1 463 ? -1.107  -30.415 12.523 1.00 35.69  ? 442  THR A CA    1 ? 
ATOM   3445 C C     . THR A 1 463 ? -0.494  -31.761 12.929 1.00 34.33  ? 442  THR A C     1 ? 
ATOM   3446 O O     . THR A 1 463 ? -1.201  -32.728 13.185 1.00 36.56  ? 442  THR A O     1 ? 
ATOM   3447 C CB    . THR A 1 463 ? -2.489  -30.215 13.151 1.00 33.52  ? 442  THR A CB    1 ? 
ATOM   3448 O OG1   . THR A 1 463 ? -3.040  -28.990 12.682 1.00 31.43  ? 442  THR A OG1   1 ? 
ATOM   3449 C CG2   . THR A 1 463 ? -2.454  -30.169 14.669 1.00 33.66  ? 442  THR A CG2   1 ? 
ATOM   3450 N N     . TYR A 1 464 ? 0.832   -31.829 12.977 1.00 35.24  ? 443  TYR A N     1 ? 
ATOM   3451 C CA    . TYR A 1 464 ? 1.503   -33.062 13.364 1.00 38.73  ? 443  TYR A CA    1 ? 
ATOM   3452 C C     . TYR A 1 464 ? 1.772   -33.071 14.871 1.00 37.18  ? 443  TYR A C     1 ? 
ATOM   3453 O O     . TYR A 1 464 ? 1.351   -33.980 15.576 1.00 36.92  ? 443  TYR A O     1 ? 
ATOM   3454 C CB    . TYR A 1 464 ? 2.775   -33.190 12.527 1.00 40.46  ? 443  TYR A CB    1 ? 
ATOM   3455 C CG    . TYR A 1 464 ? 3.653   -34.364 12.918 1.00 46.93  ? 443  TYR A CG    1 ? 
ATOM   3456 C CD1   . TYR A 1 464 ? 3.124   -35.640 13.067 1.00 55.15  ? 443  TYR A CD1   1 ? 
ATOM   3457 C CD2   . TYR A 1 464 ? 5.000   -34.179 13.191 1.00 51.89  ? 443  TYR A CD2   1 ? 
ATOM   3458 C CE1   . TYR A 1 464 ? 3.931   -36.717 13.397 1.00 60.35  ? 443  TYR A CE1   1 ? 
ATOM   3459 C CE2   . TYR A 1 464 ? 5.813   -35.240 13.550 1.00 56.91  ? 443  TYR A CE2   1 ? 
ATOM   3460 C CZ    . TYR A 1 464 ? 5.277   -36.512 13.645 1.00 64.02  ? 443  TYR A CZ    1 ? 
ATOM   3461 O OH    . TYR A 1 464 ? 6.082   -37.551 14.005 1.00 77.93  ? 443  TYR A OH    1 ? 
ATOM   3462 N N     . LEU A 1 465 ? 2.496   -32.058 15.361 1.00 33.41  ? 444  LEU A N     1 ? 
ATOM   3463 C CA    . LEU A 1 465 ? 2.752   -31.922 16.790 1.00 33.31  ? 444  LEU A CA    1 ? 
ATOM   3464 C C     . LEU A 1 465 ? 2.326   -30.518 17.243 1.00 31.48  ? 444  LEU A C     1 ? 
ATOM   3465 O O     . LEU A 1 465 ? 2.398   -29.579 16.442 1.00 25.73  ? 444  LEU A O     1 ? 
ATOM   3466 C CB    . LEU A 1 465 ? 4.230   -32.188 17.057 1.00 32.20  ? 444  LEU A CB    1 ? 
ATOM   3467 C CG    . LEU A 1 465 ? 4.652   -33.666 16.979 1.00 33.88  ? 444  LEU A CG    1 ? 
ATOM   3468 C CD1   . LEU A 1 465 ? 6.151   -33.774 16.947 1.00 37.03  ? 444  LEU A CD1   1 ? 
ATOM   3469 C CD2   . LEU A 1 465 ? 4.123   -34.506 18.126 1.00 33.91  ? 444  LEU A CD2   1 ? 
ATOM   3470 N N     . ALA A 1 466 ? 1.865   -30.426 18.509 1.00 30.60  ? 445  ALA A N     1 ? 
ATOM   3471 C CA    . ALA A 1 466 ? 1.307   -29.200 19.074 1.00 30.84  ? 445  ALA A CA    1 ? 
ATOM   3472 C C     . ALA A 1 466 ? 1.971   -28.834 20.403 1.00 32.70  ? 445  ALA A C     1 ? 
ATOM   3473 O O     . ALA A 1 466 ? 2.352   -29.715 21.171 1.00 30.97  ? 445  ALA A O     1 ? 
ATOM   3474 C CB    . ALA A 1 466 ? -0.164  -29.367 19.288 1.00 29.21  ? 445  ALA A CB    1 ? 
ATOM   3475 N N     . HIS A 1 467 ? 2.097   -27.515 20.658 1.00 30.53  ? 446  HIS A N     1 ? 
ATOM   3476 C CA    . HIS A 1 467 ? 2.444   -26.977 21.966 1.00 28.86  ? 446  HIS A CA    1 ? 
ATOM   3477 C C     . HIS A 1 467 ? 1.418   -25.910 22.334 1.00 29.56  ? 446  HIS A C     1 ? 
ATOM   3478 O O     . HIS A 1 467 ? 1.292   -24.926 21.594 1.00 29.32  ? 446  HIS A O     1 ? 
ATOM   3479 C CB    . HIS A 1 467 ? 3.835   -26.336 21.944 1.00 29.67  ? 446  HIS A CB    1 ? 
ATOM   3480 C CG    . HIS A 1 467 ? 4.173   -25.586 23.191 1.00 31.13  ? 446  HIS A CG    1 ? 
ATOM   3481 N ND1   . HIS A 1 467 ? 4.722   -26.208 24.292 1.00 29.47  ? 446  HIS A ND1   1 ? 
ATOM   3482 C CD2   . HIS A 1 467 ? 4.032   -24.267 23.524 1.00 29.40  ? 446  HIS A CD2   1 ? 
ATOM   3483 C CE1   . HIS A 1 467 ? 4.914   -25.290 25.242 1.00 33.84  ? 446  HIS A CE1   1 ? 
ATOM   3484 N NE2   . HIS A 1 467 ? 4.478   -24.119 24.806 1.00 28.45  ? 446  HIS A NE2   1 ? 
ATOM   3485 N N     . PRO A 1 468 ? 0.647   -26.056 23.438 1.00 28.13  ? 447  PRO A N     1 ? 
ATOM   3486 C CA    . PRO A 1 468 ? 0.604   -27.273 24.253 1.00 29.24  ? 447  PRO A CA    1 ? 
ATOM   3487 C C     . PRO A 1 468 ? 0.053   -28.468 23.477 1.00 29.26  ? 447  PRO A C     1 ? 
ATOM   3488 O O     . PRO A 1 468 ? -0.603  -28.293 22.461 1.00 30.27  ? 447  PRO A O     1 ? 
ATOM   3489 C CB    . PRO A 1 468 ? -0.346  -26.934 25.400 1.00 31.95  ? 447  PRO A CB    1 ? 
ATOM   3490 C CG    . PRO A 1 468 ? -0.506  -25.440 25.372 1.00 31.50  ? 447  PRO A CG    1 ? 
ATOM   3491 C CD    . PRO A 1 468 ? -0.279  -25.038 23.928 1.00 32.83  ? 447  PRO A CD    1 ? 
ATOM   3492 N N     . ALA A 1 469 ? 0.260   -29.674 24.009 1.00 36.86  ? 448  ALA A N     1 ? 
ATOM   3493 C CA    . ALA A 1 469 ? -0.308  -30.874 23.412 1.00 37.47  ? 448  ALA A CA    1 ? 
ATOM   3494 C C     . ALA A 1 469 ? -1.824  -30.765 23.443 1.00 37.45  ? 448  ALA A C     1 ? 
ATOM   3495 O O     . ALA A 1 469 ? -2.403  -30.146 24.337 1.00 36.75  ? 448  ALA A O     1 ? 
ATOM   3496 C CB    . ALA A 1 469 ? 0.195   -32.114 24.137 1.00 38.52  ? 448  ALA A CB    1 ? 
ATOM   3497 N N     . LEU A 1 470 ? -2.475  -31.360 22.441 1.00 37.13  ? 449  LEU A N     1 ? 
ATOM   3498 C CA    . LEU A 1 470 ? -3.921  -31.287 22.315 1.00 39.32  ? 449  LEU A CA    1 ? 
ATOM   3499 C C     . LEU A 1 470 ? -4.605  -32.037 23.454 1.00 40.59  ? 449  LEU A C     1 ? 
ATOM   3500 O O     . LEU A 1 470 ? -5.749  -31.727 23.756 1.00 39.07  ? 449  LEU A O     1 ? 
ATOM   3501 C CB    . LEU A 1 470 ? -4.329  -31.793 20.931 1.00 43.48  ? 449  LEU A CB    1 ? 
ATOM   3502 C CG    . LEU A 1 470 ? -3.734  -30.998 19.757 1.00 48.19  ? 449  LEU A CG    1 ? 
ATOM   3503 C CD1   . LEU A 1 470 ? -3.994  -31.600 18.376 1.00 54.00  ? 449  LEU A CD1   1 ? 
ATOM   3504 C CD2   . LEU A 1 470 ? -4.241  -29.556 19.798 1.00 49.64  ? 449  LEU A CD2   1 ? 
ATOM   3505 N N     . ASP A 1 471 ? -3.882  -32.969 24.106 1.00 40.42  ? 450  ASP A N     1 ? 
ATOM   3506 C CA    . ASP A 1 471 ? -4.404  -33.767 25.207 1.00 42.90  ? 450  ASP A CA    1 ? 
ATOM   3507 C C     . ASP A 1 471 ? -3.981  -33.216 26.570 1.00 40.12  ? 450  ASP A C     1 ? 
ATOM   3508 O O     . ASP A 1 471 ? -4.235  -33.846 27.588 1.00 39.26  ? 450  ASP A O     1 ? 
ATOM   3509 C CB    . ASP A 1 471 ? -3.981  -35.229 25.064 1.00 49.13  ? 450  ASP A CB    1 ? 
ATOM   3510 C CG    . ASP A 1 471 ? -2.483  -35.516 25.120 1.00 50.88  ? 450  ASP A CG    1 ? 
ATOM   3511 O OD1   . ASP A 1 471 ? -1.704  -34.594 25.395 1.00 53.62  ? 450  ASP A OD1   1 ? 
ATOM   3512 O OD2   . ASP A 1 471 ? -2.083  -36.657 24.851 1.00 54.17  ? 450  ASP A OD2   1 ? 
ATOM   3513 N N     . ALA A 1 472 ? -3.339  -32.042 26.615 1.00 38.41  ? 451  ALA A N     1 ? 
ATOM   3514 C CA    . ALA A 1 472 ? -2.819  -31.501 27.866 1.00 35.01  ? 451  ALA A CA    1 ? 
ATOM   3515 C C     . ALA A 1 472 ? -3.939  -31.250 28.863 1.00 30.74  ? 451  ALA A C     1 ? 
ATOM   3516 O O     . ALA A 1 472 ? -5.036  -30.848 28.484 1.00 35.75  ? 451  ALA A O     1 ? 
ATOM   3517 C CB    . ALA A 1 472 ? -2.054  -30.214 27.602 1.00 35.24  ? 451  ALA A CB    1 ? 
ATOM   3518 N N     . THR A 1 473 ? -3.625  -31.447 30.149 1.00 29.45  ? 452  THR A N     1 ? 
ATOM   3519 C CA    . THR A 1 473 ? -4.554  -31.217 31.235 1.00 33.36  ? 452  THR A CA    1 ? 
ATOM   3520 C C     . THR A 1 473 ? -4.688  -29.707 31.445 1.00 36.04  ? 452  THR A C     1 ? 
ATOM   3521 O O     . THR A 1 473 ? -3.832  -28.951 31.001 1.00 29.14  ? 452  THR A O     1 ? 
ATOM   3522 C CB    . THR A 1 473 ? -4.044  -31.918 32.499 1.00 35.92  ? 452  THR A CB    1 ? 
ATOM   3523 O OG1   . THR A 1 473 ? -2.777  -31.355 32.844 1.00 29.73  ? 452  THR A OG1   1 ? 
ATOM   3524 C CG2   . THR A 1 473 ? -3.876  -33.422 32.298 1.00 38.74  ? 452  THR A CG2   1 ? 
ATOM   3525 N N     . ASP A 1 474 ? -5.738  -29.293 32.154 1.00 35.58  ? 453  ASP A N     1 ? 
ATOM   3526 C CA    . ASP A 1 474 ? -5.891  -27.908 32.574 1.00 40.10  ? 453  ASP A CA    1 ? 
ATOM   3527 C C     . ASP A 1 474 ? -4.662  -27.423 33.347 1.00 35.47  ? 453  ASP A C     1 ? 
ATOM   3528 O O     . ASP A 1 474 ? -4.228  -26.282 33.173 1.00 29.69  ? 453  ASP A O     1 ? 
ATOM   3529 C CB    . ASP A 1 474 ? -7.160  -27.720 33.385 1.00 45.76  ? 453  ASP A CB    1 ? 
ATOM   3530 C CG    . ASP A 1 474 ? -8.427  -27.470 32.586 1.00 48.18  ? 453  ASP A CG    1 ? 
ATOM   3531 O OD1   . ASP A 1 474 ? -8.394  -27.653 31.361 1.00 52.65  ? 453  ASP A OD1   1 ? 
ATOM   3532 O OD2   . ASP A 1 474 ? -9.431  -27.074 33.218 1.00 60.88  ? 453  ASP A OD2   1 ? 
ATOM   3533 N N     . GLU A 1 475 ? -4.090  -28.288 34.190 1.00 31.74  ? 454  GLU A N     1 ? 
ATOM   3534 C CA    . GLU A 1 475 ? -2.949  -27.940 35.018 1.00 31.24  ? 454  GLU A CA    1 ? 
ATOM   3535 C C     . GLU A 1 475 ? -1.728  -27.612 34.148 1.00 33.81  ? 454  GLU A C     1 ? 
ATOM   3536 O O     . GLU A 1 475 ? -0.968  -26.677 34.440 1.00 29.82  ? 454  GLU A O     1 ? 
ATOM   3537 C CB    . GLU A 1 475 ? -2.681  -29.105 35.974 1.00 36.87  ? 454  GLU A CB    1 ? 
ATOM   3538 C CG    . GLU A 1 475 ? -1.577  -28.842 36.993 1.00 38.95  ? 454  GLU A CG    1 ? 
ATOM   3539 C CD    . GLU A 1 475 ? -0.823  -30.105 37.389 1.00 51.53  ? 454  GLU A CD    1 ? 
ATOM   3540 O OE1   . GLU A 1 475 ? -0.729  -30.370 38.601 1.00 53.03  ? 454  GLU A OE1   1 ? 
ATOM   3541 O OE2   . GLU A 1 475 ? -0.309  -30.823 36.493 1.00 61.05  ? 454  GLU A OE2   1 ? 
ATOM   3542 N N     . ILE A 1 476 ? -1.505  -28.441 33.121 1.00 30.33  ? 455  ILE A N     1 ? 
ATOM   3543 C CA    . ILE A 1 476 ? -0.419  -28.202 32.191 1.00 29.24  ? 455  ILE A CA    1 ? 
ATOM   3544 C C     . ILE A 1 476 ? -0.674  -26.914 31.399 1.00 27.23  ? 455  ILE A C     1 ? 
ATOM   3545 O O     . ILE A 1 476 ? 0.242   -26.123 31.231 1.00 26.23  ? 455  ILE A O     1 ? 
ATOM   3546 C CB    . ILE A 1 476 ? -0.194  -29.413 31.266 1.00 33.04  ? 455  ILE A CB    1 ? 
ATOM   3547 C CG1   . ILE A 1 476 ? 0.306   -30.653 32.045 1.00 39.45  ? 455  ILE A CG1   1 ? 
ATOM   3548 C CG2   . ILE A 1 476 ? 0.787   -29.046 30.157 1.00 32.32  ? 455  ILE A CG2   1 ? 
ATOM   3549 C CD1   . ILE A 1 476 ? 0.132   -31.960 31.272 1.00 47.75  ? 455  ILE A CD1   1 ? 
ATOM   3550 N N     . ILE A 1 477 ? -1.895  -26.695 30.899 1.00 25.95  ? 456  ILE A N     1 ? 
ATOM   3551 C CA    . ILE A 1 477 ? -2.191  -25.464 30.175 1.00 28.30  ? 456  ILE A CA    1 ? 
ATOM   3552 C C     . ILE A 1 477 ? -1.954  -24.241 31.079 1.00 25.14  ? 456  ILE A C     1 ? 
ATOM   3553 O O     . ILE A 1 477 ? -1.284  -23.303 30.665 1.00 22.87  ? 456  ILE A O     1 ? 
ATOM   3554 C CB    . ILE A 1 477 ? -3.606  -25.492 29.587 1.00 26.14  ? 456  ILE A CB    1 ? 
ATOM   3555 C CG1   . ILE A 1 477 ? -3.698  -26.571 28.482 1.00 28.21  ? 456  ILE A CG1   1 ? 
ATOM   3556 C CG2   . ILE A 1 477 ? -4.013  -24.117 29.049 1.00 25.16  ? 456  ILE A CG2   1 ? 
ATOM   3557 C CD1   . ILE A 1 477 ? -5.099  -26.822 27.969 1.00 31.59  ? 456  ILE A CD1   1 ? 
ATOM   3558 N N     . GLU A 1 478 ? -2.489  -24.273 32.305 1.00 24.35  ? 457  GLU A N     1 ? 
ATOM   3559 C CA    . GLU A 1 478 ? -2.345  -23.166 33.231 1.00 23.28  ? 457  GLU A CA    1 ? 
ATOM   3560 C C     . GLU A 1 478 ? -0.871  -22.845 33.438 1.00 24.97  ? 457  GLU A C     1 ? 
ATOM   3561 O O     . GLU A 1 478 ? -0.476  -21.680 33.363 1.00 22.58  ? 457  GLU A O     1 ? 
ATOM   3562 C CB    . GLU A 1 478 ? -3.037  -23.404 34.574 1.00 25.81  ? 457  GLU A CB    1 ? 
ATOM   3563 C CG    . GLU A 1 478 ? -2.831  -22.228 35.537 1.00 24.55  ? 457  GLU A CG    1 ? 
ATOM   3564 C CD    . GLU A 1 478 ? -3.620  -22.303 36.833 1.00 27.51  ? 457  GLU A CD    1 ? 
ATOM   3565 O OE1   . GLU A 1 478 ? -3.362  -21.432 37.713 1.00 24.10  ? 457  GLU A OE1   1 ? 
ATOM   3566 O OE2   . GLU A 1 478 ? -4.466  -23.236 36.943 1.00 28.27  ? 457  GLU A OE2   1 ? 
ATOM   3567 N N     . SER A 1 479 ? -0.057  -23.883 33.686 1.00 22.22  ? 458  SER A N     1 ? 
ATOM   3568 C CA    . SER A 1 479 ? 1.354   -23.706 33.940 1.00 26.44  ? 458  SER A CA    1 ? 
ATOM   3569 C C     . SER A 1 479 ? 2.057   -23.054 32.750 1.00 23.98  ? 458  SER A C     1 ? 
ATOM   3570 O O     . SER A 1 479 ? 2.932   -22.209 32.946 1.00 23.57  ? 458  SER A O     1 ? 
ATOM   3571 C CB    . SER A 1 479 ? 1.995   -25.051 34.297 1.00 31.75  ? 458  SER A CB    1 ? 
ATOM   3572 O OG    . SER A 1 479 ? 3.376   -24.885 34.582 1.00 45.88  ? 458  SER A OG    1 ? 
ATOM   3573 N N     . LEU A 1 480 ? 1.700   -23.485 31.534 1.00 23.46  ? 459  LEU A N     1 ? 
ATOM   3574 C CA    . LEU A 1 480 ? 2.292   -22.950 30.321 1.00 24.58  ? 459  LEU A CA    1 ? 
ATOM   3575 C C     . LEU A 1 480 ? 1.888   -21.493 30.125 1.00 21.93  ? 459  LEU A C     1 ? 
ATOM   3576 O O     . LEU A 1 480 ? 2.698   -20.663 29.709 1.00 22.47  ? 459  LEU A O     1 ? 
ATOM   3577 C CB    . LEU A 1 480 ? 1.887   -23.827 29.139 1.00 25.82  ? 459  LEU A CB    1 ? 
ATOM   3578 C CG    . LEU A 1 480 ? 2.576   -25.193 29.104 1.00 30.22  ? 459  LEU A CG    1 ? 
ATOM   3579 C CD1   . LEU A 1 480 ? 2.145   -25.975 27.892 1.00 33.30  ? 459  LEU A CD1   1 ? 
ATOM   3580 C CD2   . LEU A 1 480 ? 4.090   -25.042 29.123 1.00 30.95  ? 459  LEU A CD2   1 ? 
ATOM   3581 N N     . ILE A 1 481 ? 0.637   -21.182 30.407 1.00 21.99  ? 460  ILE A N     1 ? 
ATOM   3582 C CA    . ILE A 1 481 ? 0.197   -19.798 30.300 1.00 21.53  ? 460  ILE A CA    1 ? 
ATOM   3583 C C     . ILE A 1 481 ? 1.006   -18.950 31.293 1.00 19.54  ? 460  ILE A C     1 ? 
ATOM   3584 O O     . ILE A 1 481 ? 1.582   -17.936 30.906 1.00 17.82  ? 460  ILE A O     1 ? 
ATOM   3585 C CB    . ILE A 1 481 ? -1.323  -19.673 30.482 1.00 21.94  ? 460  ILE A CB    1 ? 
ATOM   3586 C CG1   . ILE A 1 481 ? -2.080  -20.347 29.345 1.00 21.52  ? 460  ILE A CG1   1 ? 
ATOM   3587 C CG2   . ILE A 1 481 ? -1.748  -18.200 30.617 1.00 21.32  ? 460  ILE A CG2   1 ? 
ATOM   3588 C CD1   . ILE A 1 481 ? -3.581  -20.348 29.584 1.00 23.24  ? 460  ILE A CD1   1 ? 
ATOM   3589 N N     . ARG A 1 482 ? 1.085   -19.370 32.561 1.00 18.01  ? 461  ARG A N     1 ? 
ATOM   3590 C CA    . ARG A 1 482 ? 1.768   -18.540 33.542 1.00 20.08  ? 461  ARG A CA    1 ? 
ATOM   3591 C C     . ARG A 1 482 ? 3.243   -18.347 33.199 1.00 20.92  ? 461  ARG A C     1 ? 
ATOM   3592 O O     . ARG A 1 482 ? 3.839   -17.308 33.531 1.00 20.20  ? 461  ARG A O     1 ? 
ATOM   3593 C CB    . ARG A 1 482 ? 1.594   -19.025 34.975 1.00 21.83  ? 461  ARG A CB    1 ? 
ATOM   3594 C CG    . ARG A 1 482 ? 0.144   -19.026 35.431 1.00 21.45  ? 461  ARG A CG    1 ? 
ATOM   3595 C CD    . ARG A 1 482 ? 0.026   -19.259 36.911 1.00 21.38  ? 461  ARG A CD    1 ? 
ATOM   3596 N NE    . ARG A 1 482 ? -1.363  -19.391 37.359 1.00 22.32  ? 461  ARG A NE    1 ? 
ATOM   3597 C CZ    . ARG A 1 482 ? -2.105  -18.391 37.811 1.00 22.41  ? 461  ARG A CZ    1 ? 
ATOM   3598 N NH1   . ARG A 1 482 ? -1.653  -17.145 37.784 1.00 22.39  ? 461  ARG A NH1   1 ? 
ATOM   3599 N NH2   . ARG A 1 482 ? -3.333  -18.610 38.223 1.00 23.94  ? 461  ARG A NH2   1 ? 
ATOM   3600 N N     . ASN A 1 483 ? 3.853   -19.338 32.525 1.00 22.13  ? 462  ASN A N     1 ? 
ATOM   3601 C CA    . ASN A 1 483 ? 5.268   -19.271 32.203 1.00 22.58  ? 462  ASN A CA    1 ? 
ATOM   3602 C C     . ASN A 1 483 ? 5.561   -18.619 30.861 1.00 21.79  ? 462  ASN A C     1 ? 
ATOM   3603 O O     . ASN A 1 483 ? 6.675   -18.169 30.636 1.00 18.99  ? 462  ASN A O     1 ? 
ATOM   3604 C CB    . ASN A 1 483 ? 5.922   -20.643 32.292 1.00 27.94  ? 462  ASN A CB    1 ? 
ATOM   3605 C CG    . ASN A 1 483 ? 7.397   -20.513 32.540 1.00 31.45  ? 462  ASN A CG    1 ? 
ATOM   3606 O OD1   . ASN A 1 483 ? 8.213   -21.046 31.771 1.00 38.55  ? 462  ASN A OD1   1 ? 
ATOM   3607 N ND2   . ASN A 1 483 ? 7.746   -19.803 33.601 1.00 33.80  ? 462  ASN A ND2   1 ? 
ATOM   3608 N N     . GLU A 1 484 ? 4.598   -18.590 29.946 1.00 22.71  ? 463  GLU A N     1 ? 
ATOM   3609 C CA    . GLU A 1 484 ? 4.888   -18.192 28.575 1.00 22.96  ? 463  GLU A CA    1 ? 
ATOM   3610 C C     . GLU A 1 484 ? 4.031   -17.018 28.113 1.00 21.51  ? 463  GLU A C     1 ? 
ATOM   3611 O O     . GLU A 1 484 ? 4.356   -16.433 27.106 1.00 22.09  ? 463  GLU A O     1 ? 
ATOM   3612 C CB    . GLU A 1 484 ? 4.619   -19.358 27.621 1.00 23.43  ? 463  GLU A CB    1 ? 
ATOM   3613 C CG    . GLU A 1 484 ? 5.523   -20.555 27.916 1.00 25.85  ? 463  GLU A CG    1 ? 
ATOM   3614 C CD    . GLU A 1 484 ? 5.323   -21.786 27.035 1.00 27.71  ? 463  GLU A CD    1 ? 
ATOM   3615 O OE1   . GLU A 1 484 ? 6.122   -22.698 27.221 1.00 22.87  ? 463  GLU A OE1   1 ? 
ATOM   3616 O OE2   . GLU A 1 484 ? 4.437   -21.818 26.154 1.00 26.22  ? 463  GLU A OE2   1 ? 
ATOM   3617 N N     . ALA A 1 485 ? 2.883   -16.749 28.730 1.00 19.57  ? 464  ALA A N     1 ? 
ATOM   3618 C CA    . ALA A 1 485 ? 2.060   -15.630 28.275 1.00 19.00  ? 464  ALA A CA    1 ? 
ATOM   3619 C C     . ALA A 1 485 ? 2.841   -14.335 28.458 1.00 20.23  ? 464  ALA A C     1 ? 
ATOM   3620 O O     . ALA A 1 485 ? 3.685   -14.237 29.353 1.00 17.71  ? 464  ALA A O     1 ? 
ATOM   3621 C CB    . ALA A 1 485 ? 0.778   -15.601 29.046 1.00 19.07  ? 464  ALA A CB    1 ? 
ATOM   3622 N N     . SER A 1 486 ? 2.578   -13.339 27.623 1.00 18.83  ? 465  SER A N     1 ? 
ATOM   3623 C CA    . SER A 1 486 ? 3.354   -12.100 27.680 1.00 19.58  ? 465  SER A CA    1 ? 
ATOM   3624 C C     . SER A 1 486 ? 2.497   -10.936 27.175 1.00 19.33  ? 465  SER A C     1 ? 
ATOM   3625 O O     . SER A 1 486 ? 1.439   -11.153 26.586 1.00 19.09  ? 465  SER A O     1 ? 
ATOM   3626 C CB    . SER A 1 486 ? 4.650   -12.199 26.928 1.00 20.25  ? 465  SER A CB    1 ? 
ATOM   3627 O OG    . SER A 1 486 ? 5.543   -11.118 27.226 1.00 18.29  ? 465  SER A OG    1 ? 
ATOM   3628 N N     . THR A 1 487 ? 2.961   -9.717  27.477 1.00 17.45  ? 466  THR A N     1 ? 
ATOM   3629 C CA    . THR A 1 487 ? 2.246   -8.502  27.140 1.00 17.23  ? 466  THR A CA    1 ? 
ATOM   3630 C C     . THR A 1 487 ? 2.081   -8.429  25.626 1.00 16.66  ? 466  THR A C     1 ? 
ATOM   3631 O O     . THR A 1 487 ? 2.984   -8.815  24.855 1.00 18.97  ? 466  THR A O     1 ? 
ATOM   3632 C CB    . THR A 1 487 ? 3.014   -7.277  27.666 1.00 16.36  ? 466  THR A CB    1 ? 
ATOM   3633 O OG1   . THR A 1 487 ? 2.362   -6.068  27.267 1.00 14.05  ? 466  THR A OG1   1 ? 
ATOM   3634 C CG2   . THR A 1 487 ? 4.434   -7.217  27.150 1.00 16.56  ? 466  THR A CG2   1 ? 
ATOM   3635 N N     . VAL A 1 488 ? 0.931   -7.907  25.208 1.00 17.93  ? 467  VAL A N     1 ? 
ATOM   3636 C CA    . VAL A 1 488 ? 0.718   -7.579  23.809 1.00 17.88  ? 467  VAL A CA    1 ? 
ATOM   3637 C C     . VAL A 1 488 ? 0.971   -6.098  23.582 1.00 19.58  ? 467  VAL A C     1 ? 
ATOM   3638 O O     . VAL A 1 488 ? 0.612   -5.575  22.517 1.00 17.42  ? 467  VAL A O     1 ? 
ATOM   3639 C CB    . VAL A 1 488 ? -0.690  -7.975  23.326 1.00 20.77  ? 467  VAL A CB    1 ? 
ATOM   3640 C CG1   . VAL A 1 488 ? -0.766  -7.972  21.795 1.00 22.12  ? 467  VAL A CG1   1 ? 
ATOM   3641 C CG2   . VAL A 1 488 ? -1.123  -9.313  23.928 1.00 19.97  ? 467  VAL A CG2   1 ? 
ATOM   3642 N N     . PHE A 1 489 ? 1.574   -5.412  24.587 1.00 18.35  ? 468  PHE A N     1 ? 
ATOM   3643 C CA    . PHE A 1 489 ? 2.071   -4.055  24.414 1.00 17.83  ? 468  PHE A CA    1 ? 
ATOM   3644 C C     . PHE A 1 489 ? 0.914   -3.069  24.305 1.00 16.79  ? 468  PHE A C     1 ? 
ATOM   3645 O O     . PHE A 1 489 ? 1.063   -2.042  23.637 1.00 18.62  ? 468  PHE A O     1 ? 
ATOM   3646 C CB    . PHE A 1 489 ? 3.049   -3.925  23.233 1.00 19.12  ? 468  PHE A CB    1 ? 
ATOM   3647 C CG    . PHE A 1 489 ? 4.108   -5.016  23.157 1.00 19.64  ? 468  PHE A CG    1 ? 
ATOM   3648 C CD1   . PHE A 1 489 ? 5.116   -5.118  24.123 1.00 19.27  ? 468  PHE A CD1   1 ? 
ATOM   3649 C CD2   . PHE A 1 489 ? 4.080   -5.935  22.126 1.00 21.51  ? 468  PHE A CD2   1 ? 
ATOM   3650 C CE1   . PHE A 1 489 ? 6.074   -6.119  24.042 1.00 20.94  ? 468  PHE A CE1   1 ? 
ATOM   3651 C CE2   . PHE A 1 489 ? 5.017   -6.964  22.069 1.00 21.00  ? 468  PHE A CE2   1 ? 
ATOM   3652 C CZ    . PHE A 1 489 ? 6.034   -7.021  22.996 1.00 22.48  ? 468  PHE A CZ    1 ? 
ATOM   3653 N N     . HIS A 1 490 ? -0.174  -3.291  25.073 1.00 17.13  ? 469  HIS A N     1 ? 
ATOM   3654 C CA    . HIS A 1 490 ? -1.326  -2.410  25.018 1.00 17.68  ? 469  HIS A CA    1 ? 
ATOM   3655 C C     . HIS A 1 490 ? -1.633  -1.774  26.373 1.00 16.65  ? 469  HIS A C     1 ? 
ATOM   3656 O O     . HIS A 1 490 ? -2.782  -1.789  26.814 1.00 16.99  ? 469  HIS A O     1 ? 
ATOM   3657 C CB    . HIS A 1 490 ? -2.565  -3.158  24.501 1.00 17.14  ? 469  HIS A CB    1 ? 
ATOM   3658 C CG    . HIS A 1 490 ? -2.397  -3.798  23.164 1.00 18.00  ? 469  HIS A CG    1 ? 
ATOM   3659 N ND1   . HIS A 1 490 ? -3.145  -4.901  22.780 1.00 17.63  ? 469  HIS A ND1   1 ? 
ATOM   3660 C CD2   . HIS A 1 490 ? -1.581  -3.510  22.121 1.00 16.41  ? 469  HIS A CD2   1 ? 
ATOM   3661 C CE1   . HIS A 1 490 ? -2.801  -5.242  21.530 1.00 18.15  ? 469  HIS A CE1   1 ? 
ATOM   3662 N NE2   . HIS A 1 490 ? -1.839  -4.423  21.124 1.00 17.18  ? 469  HIS A NE2   1 ? 
ATOM   3663 N N     . PRO A 1 491 ? -0.657  -1.189  27.103 1.00 17.31  ? 470  PRO A N     1 ? 
ATOM   3664 C CA    . PRO A 1 491 ? -0.979  -0.614  28.406 1.00 16.88  ? 470  PRO A CA    1 ? 
ATOM   3665 C C     . PRO A 1 491 ? -1.866  0.622   28.267 1.00 15.53  ? 470  PRO A C     1 ? 
ATOM   3666 O O     . PRO A 1 491 ? -1.584  1.476   27.454 1.00 16.65  ? 470  PRO A O     1 ? 
ATOM   3667 C CB    . PRO A 1 491 ? 0.382   -0.292  28.987 1.00 16.67  ? 470  PRO A CB    1 ? 
ATOM   3668 C CG    . PRO A 1 491 ? 1.233   0.017   27.768 1.00 17.72  ? 470  PRO A CG    1 ? 
ATOM   3669 C CD    . PRO A 1 491 ? 0.748   -0.967  26.704 1.00 17.91  ? 470  PRO A CD    1 ? 
ATOM   3670 N N     . VAL A 1 492 ? -2.873  0.733   29.126 1.00 15.63  ? 471  VAL A N     1 ? 
ATOM   3671 C CA    . VAL A 1 492 ? -3.817  1.848   29.108 1.00 16.11  ? 471  VAL A CA    1 ? 
ATOM   3672 C C     . VAL A 1 492 ? -4.220  2.138   30.540 1.00 15.11  ? 471  VAL A C     1 ? 
ATOM   3673 O O     . VAL A 1 492 ? -3.944  1.340   31.444 1.00 16.08  ? 471  VAL A O     1 ? 
ATOM   3674 C CB    . VAL A 1 492 ? -5.083  1.577   28.257 1.00 15.83  ? 471  VAL A CB    1 ? 
ATOM   3675 C CG1   . VAL A 1 492 ? -4.774  1.198   26.824 1.00 16.73  ? 471  VAL A CG1   1 ? 
ATOM   3676 C CG2   . VAL A 1 492 ? -6.003  0.537   28.895 1.00 16.14  ? 471  VAL A CG2   1 ? 
ATOM   3677 N N     . GLY A 1 493 ? -4.862  3.291   30.749 1.00 17.10  ? 472  GLY A N     1 ? 
ATOM   3678 C CA    . GLY A 1 493 ? -5.786  3.447   31.875 1.00 17.16  ? 472  GLY A CA    1 ? 
ATOM   3679 C C     . GLY A 1 493 ? -5.286  4.195   33.114 1.00 16.76  ? 472  GLY A C     1 ? 
ATOM   3680 O O     . GLY A 1 493 ? -6.068  4.363   34.054 1.00 16.54  ? 472  GLY A O     1 ? 
ATOM   3681 N N     . THR A 1 494 ? -4.042  4.677   33.106 1.00 17.10  ? 473  THR A N     1 ? 
ATOM   3682 C CA    . THR A 1 494 ? -3.380  5.257   34.272 1.00 17.53  ? 473  THR A CA    1 ? 
ATOM   3683 C C     . THR A 1 494 ? -3.724  6.735   34.497 1.00 18.57  ? 473  THR A C     1 ? 
ATOM   3684 O O     . THR A 1 494 ? -3.283  7.282   35.499 1.00 19.20  ? 473  THR A O     1 ? 
ATOM   3685 C CB    . THR A 1 494 ? -1.871  5.065   34.144 1.00 18.57  ? 473  THR A CB    1 ? 
ATOM   3686 O OG1   . THR A 1 494 ? -1.511  5.578   32.865 1.00 20.12  ? 473  THR A OG1   1 ? 
ATOM   3687 C CG2   . THR A 1 494 ? -1.464  3.612   34.327 1.00 19.32  ? 473  THR A CG2   1 ? 
ATOM   3688 N N     . ALA A 1 495 ? -4.483  7.363   33.582 1.00 18.05  ? 474  ALA A N     1 ? 
ATOM   3689 C CA    . ALA A 1 495 ? -5.100  8.661   33.810 1.00 17.94  ? 474  ALA A CA    1 ? 
ATOM   3690 C C     . ALA A 1 495 ? -6.514  8.640   33.242 1.00 21.79  ? 474  ALA A C     1 ? 
ATOM   3691 O O     . ALA A 1 495 ? -6.878  9.436   32.382 1.00 22.66  ? 474  ALA A O     1 ? 
ATOM   3692 C CB    . ALA A 1 495 ? -4.261  9.795   33.236 1.00 18.00  ? 474  ALA A CB    1 ? 
ATOM   3693 N N     . ARG A 1 496 ? -7.328  7.722   33.797 1.00 22.97  ? 475  ARG A N     1 ? 
ATOM   3694 C CA    . ARG A 1 496 ? -8.601  7.345   33.226 1.00 19.08  ? 475  ARG A CA    1 ? 
ATOM   3695 C C     . ARG A 1 496 ? -9.550  8.540   33.059 1.00 18.66  ? 475  ARG A C     1 ? 
ATOM   3696 O O     . ARG A 1 496 ? -9.771  9.314   33.966 1.00 18.90  ? 475  ARG A O     1 ? 
ATOM   3697 C CB    . ARG A 1 496 ? -9.286  6.288   34.103 1.00 18.71  ? 475  ARG A CB    1 ? 
ATOM   3698 C CG    . ARG A 1 496 ? -10.652 5.868   33.589 1.00 19.55  ? 475  ARG A CG    1 ? 
ATOM   3699 C CD    . ARG A 1 496 ? -11.166 4.616   34.282 1.00 20.55  ? 475  ARG A CD    1 ? 
ATOM   3700 N NE    . ARG A 1 496 ? -11.378 4.792   35.723 1.00 19.62  ? 475  ARG A NE    1 ? 
ATOM   3701 C CZ    . ARG A 1 496 ? -12.401 5.418   36.281 1.00 21.78  ? 475  ARG A CZ    1 ? 
ATOM   3702 N NH1   . ARG A 1 496 ? -13.362 5.927   35.531 1.00 23.84  ? 475  ARG A NH1   1 ? 
ATOM   3703 N NH2   . ARG A 1 496 ? -12.483 5.481   37.597 1.00 23.58  ? 475  ARG A NH2   1 ? 
ATOM   3704 N N     . MET A 1 497 ? -10.141 8.634   31.880 1.00 18.95  ? 476  MET A N     1 ? 
ATOM   3705 C CA    . MET A 1 497 ? -11.202 9.571   31.588 1.00 19.99  ? 476  MET A CA    1 ? 
ATOM   3706 C C     . MET A 1 497 ? -12.525 9.018   32.091 1.00 21.59  ? 476  MET A C     1 ? 
ATOM   3707 O O     . MET A 1 497 ? -12.890 7.875   31.803 1.00 20.47  ? 476  MET A O     1 ? 
ATOM   3708 C CB    . MET A 1 497 ? -11.342 9.771   30.072 1.00 22.09  ? 476  MET A CB    1 ? 
ATOM   3709 C CG    . MET A 1 497 ? -12.480 10.681  29.704 1.00 21.42  ? 476  MET A CG    1 ? 
ATOM   3710 S SD    . MET A 1 497 ? -12.461 11.006  27.943 1.00 23.68  ? 476  MET A SD    1 ? 
ATOM   3711 C CE    . MET A 1 497 ? -12.729 9.345   27.281 1.00 21.82  ? 476  MET A CE    1 ? 
ATOM   3712 N N     . GLY A 1 498 ? -13.250 9.854   32.843 1.00 22.09  ? 477  GLY A N     1 ? 
ATOM   3713 C CA    . GLY A 1 498 ? -14.576 9.492   33.286 1.00 24.31  ? 477  GLY A CA    1 ? 
ATOM   3714 C C     . GLY A 1 498 ? -15.288 10.698  33.904 1.00 25.91  ? 477  GLY A C     1 ? 
ATOM   3715 O O     . GLY A 1 498 ? -15.017 11.850  33.550 1.00 23.37  ? 477  GLY A O     1 ? 
ATOM   3716 N N     . ASP A 1 499 ? -16.217 10.401  34.811 1.00 25.86  ? 478  ASP A N     1 ? 
ATOM   3717 C CA    . ASP A 1 499 ? -17.045 11.431  35.425 1.00 26.32  ? 478  ASP A CA    1 ? 
ATOM   3718 C C     . ASP A 1 499 ? -16.354 11.856  36.706 1.00 23.36  ? 478  ASP A C     1 ? 
ATOM   3719 O O     . ASP A 1 499 ? -16.487 11.186  37.719 1.00 26.23  ? 478  ASP A O     1 ? 
ATOM   3720 C CB    . ASP A 1 499 ? -18.448 10.909  35.715 1.00 31.00  ? 478  ASP A CB    1 ? 
ATOM   3721 C CG    . ASP A 1 499 ? -19.399 11.917  36.358 1.00 31.52  ? 478  ASP A CG    1 ? 
ATOM   3722 O OD1   . ASP A 1 499 ? -18.934 12.966  36.789 1.00 31.97  ? 478  ASP A OD1   1 ? 
ATOM   3723 O OD2   . ASP A 1 499 ? -20.607 11.645  36.413 1.00 39.97  ? 478  ASP A OD2   1 ? 
ATOM   3724 N N     . VAL A 1 500 ? -15.627 12.966  36.663 1.00 23.36  ? 479  VAL A N     1 ? 
ATOM   3725 C CA    . VAL A 1 500 ? -14.824 13.393  37.797 1.00 25.53  ? 479  VAL A CA    1 ? 
ATOM   3726 C C     . VAL A 1 500 ? -15.700 14.032  38.881 1.00 30.77  ? 479  VAL A C     1 ? 
ATOM   3727 O O     . VAL A 1 500 ? -15.192 14.308  39.967 1.00 28.86  ? 479  VAL A O     1 ? 
ATOM   3728 C CB    . VAL A 1 500 ? -13.690 14.355  37.375 1.00 25.75  ? 479  VAL A CB    1 ? 
ATOM   3729 C CG1   . VAL A 1 500 ? -12.748 13.708  36.360 1.00 25.79  ? 479  VAL A CG1   1 ? 
ATOM   3730 C CG2   . VAL A 1 500 ? -14.185 15.700  36.849 1.00 26.41  ? 479  VAL A CG2   1 ? 
ATOM   3731 N N     . GLU A 1 501 ? -16.998 14.260  38.607 1.00 33.95  ? 480  GLU A N     1 ? 
ATOM   3732 C CA    . GLU A 1 501 ? -17.891 14.765  39.641 1.00 37.32  ? 480  GLU A CA    1 ? 
ATOM   3733 C C     . GLU A 1 501 ? -18.313 13.642  40.574 1.00 34.45  ? 480  GLU A C     1 ? 
ATOM   3734 O O     . GLU A 1 501 ? -18.421 13.866  41.771 1.00 29.52  ? 480  GLU A O     1 ? 
ATOM   3735 C CB    . GLU A 1 501 ? -19.107 15.470  39.040 1.00 42.27  ? 480  GLU A CB    1 ? 
ATOM   3736 C CG    . GLU A 1 501 ? -18.759 16.810  38.399 1.00 52.94  ? 480  GLU A CG    1 ? 
ATOM   3737 C CD    . GLU A 1 501 ? -18.020 17.732  39.355 1.00 64.26  ? 480  GLU A CD    1 ? 
ATOM   3738 O OE1   . GLU A 1 501 ? -16.950 18.304  39.020 1.00 70.34  ? 480  GLU A OE1   1 ? 
ATOM   3739 O OE2   . GLU A 1 501 ? -18.522 17.824  40.499 1.00 76.44  ? 480  GLU A OE2   1 ? 
ATOM   3740 N N     . ASN A 1 502 ? -18.541 12.438  40.021 1.00 30.01  ? 481  ASN A N     1 ? 
ATOM   3741 C CA    . ASN A 1 502 ? -19.207 11.375  40.752 1.00 28.92  ? 481  ASN A CA    1 ? 
ATOM   3742 C C     . ASN A 1 502 ? -18.301 10.160  40.943 1.00 31.35  ? 481  ASN A C     1 ? 
ATOM   3743 O O     . ASN A 1 502 ? -18.617 9.300   41.748 1.00 33.55  ? 481  ASN A O     1 ? 
ATOM   3744 C CB    . ASN A 1 502 ? -20.541 11.033  40.099 1.00 32.26  ? 481  ASN A CB    1 ? 
ATOM   3745 C CG    . ASN A 1 502 ? -21.415 12.269  40.009 1.00 35.58  ? 481  ASN A CG    1 ? 
ATOM   3746 O OD1   . ASN A 1 502 ? -21.765 12.863  41.034 1.00 38.69  ? 481  ASN A OD1   1 ? 
ATOM   3747 N ND2   . ASN A 1 502 ? -21.703 12.752  38.808 1.00 36.52  ? 481  ASN A ND2   1 ? 
ATOM   3748 N N     . ASP A 1 503 ? -17.162 10.098  40.254 1.00 25.68  ? 482  ASP A N     1 ? 
ATOM   3749 C CA    . ASP A 1 503 ? -16.270 8.943   40.343 1.00 26.58  ? 482  ASP A CA    1 ? 
ATOM   3750 C C     . ASP A 1 503 ? -14.939 9.399   40.928 1.00 25.96  ? 482  ASP A C     1 ? 
ATOM   3751 O O     . ASP A 1 503 ? -14.184 10.087  40.244 1.00 23.94  ? 482  ASP A O     1 ? 
ATOM   3752 C CB    . ASP A 1 503 ? -16.144 8.365   38.939 1.00 26.50  ? 482  ASP A CB    1 ? 
ATOM   3753 C CG    . ASP A 1 503 ? -15.234 7.168   38.745 1.00 26.44  ? 482  ASP A CG    1 ? 
ATOM   3754 O OD1   . ASP A 1 503 ? -14.501 6.825   39.697 1.00 22.07  ? 482  ASP A OD1   1 ? 
ATOM   3755 O OD2   . ASP A 1 503 ? -15.307 6.606   37.638 1.00 27.45  ? 482  ASP A OD2   1 ? 
ATOM   3756 N N     . SER A 1 504 ? -14.638 9.009   42.178 1.00 24.63  ? 483  SER A N     1 ? 
ATOM   3757 C CA    . SER A 1 504 ? -13.432 9.436   42.854 1.00 27.29  ? 483  SER A CA    1 ? 
ATOM   3758 C C     . SER A 1 504 ? -12.134 8.999   42.149 1.00 23.71  ? 483  SER A C     1 ? 
ATOM   3759 O O     . SER A 1 504 ? -11.087 9.607   42.378 1.00 25.04  ? 483  SER A O     1 ? 
ATOM   3760 C CB    . SER A 1 504 ? -13.458 8.973   44.314 1.00 29.20  ? 483  SER A CB    1 ? 
ATOM   3761 O OG    . SER A 1 504 ? -13.299 7.563   44.385 1.00 32.47  ? 483  SER A OG    1 ? 
ATOM   3762 N N     . LEU A 1 505 ? -12.179 7.942   41.327 1.00 22.60  ? 484  LEU A N     1 ? 
ATOM   3763 C CA    . LEU A 1 505 ? -10.978 7.385   40.707 1.00 22.35  ? 484  LEU A CA    1 ? 
ATOM   3764 C C     . LEU A 1 505 ? -10.800 7.851   39.258 1.00 22.51  ? 484  LEU A C     1 ? 
ATOM   3765 O O     . LEU A 1 505 ? -9.815  7.490   38.606 1.00 20.29  ? 484  LEU A O     1 ? 
ATOM   3766 C CB    . LEU A 1 505 ? -11.015 5.864   40.796 1.00 21.69  ? 484  LEU A CB    1 ? 
ATOM   3767 C CG    . LEU A 1 505 ? -10.782 5.304   42.202 1.00 25.68  ? 484  LEU A CG    1 ? 
ATOM   3768 C CD1   . LEU A 1 505 ? -11.090 3.796   42.332 1.00 29.66  ? 484  LEU A CD1   1 ? 
ATOM   3769 C CD2   . LEU A 1 505 ? -9.347  5.606   42.587 1.00 24.98  ? 484  LEU A CD2   1 ? 
ATOM   3770 N N     . ALA A 1 506 ? -11.728 8.659   38.739 1.00 21.37  ? 485  ALA A N     1 ? 
ATOM   3771 C CA    . ALA A 1 506 ? -11.522 9.239   37.424 1.00 22.52  ? 485  ALA A CA    1 ? 
ATOM   3772 C C     . ALA A 1 506 ? -10.492 10.352  37.553 1.00 21.91  ? 485  ALA A C     1 ? 
ATOM   3773 O O     . ALA A 1 506 ? -10.403 11.025  38.597 1.00 21.48  ? 485  ALA A O     1 ? 
ATOM   3774 C CB    . ALA A 1 506 ? -12.819 9.738   36.815 1.00 23.67  ? 485  ALA A CB    1 ? 
ATOM   3775 N N     . VAL A 1 507 ? -9.669  10.484  36.512 1.00 20.48  ? 486  VAL A N     1 ? 
ATOM   3776 C CA    . VAL A 1 507 ? -8.545  11.398  36.557 1.00 21.59  ? 486  VAL A CA    1 ? 
ATOM   3777 C C     . VAL A 1 507 ? -8.861  12.612  35.691 1.00 21.84  ? 486  VAL A C     1 ? 
ATOM   3778 O O     . VAL A 1 507 ? -8.626  13.740  36.117 1.00 23.15  ? 486  VAL A O     1 ? 
ATOM   3779 C CB    . VAL A 1 507 ? -7.223  10.738  36.125 1.00 20.05  ? 486  VAL A CB    1 ? 
ATOM   3780 C CG1   . VAL A 1 507 ? -6.088  11.749  36.061 1.00 21.25  ? 486  VAL A CG1   1 ? 
ATOM   3781 C CG2   . VAL A 1 507 ? -6.859  9.590   37.053 1.00 20.17  ? 486  VAL A CG2   1 ? 
ATOM   3782 N N     . VAL A 1 508 ? -9.319  12.368  34.467 1.00 20.44  ? 487  VAL A N     1 ? 
ATOM   3783 C CA    . VAL A 1 508 ? -9.671  13.450  33.568 1.00 20.84  ? 487  VAL A CA    1 ? 
ATOM   3784 C C     . VAL A 1 508 ? -11.148 13.351  33.211 1.00 23.15  ? 487  VAL A C     1 ? 
ATOM   3785 O O     . VAL A 1 508 ? -11.735 12.272  33.254 1.00 22.43  ? 487  VAL A O     1 ? 
ATOM   3786 C CB    . VAL A 1 508 ? -8.815  13.533  32.293 1.00 21.65  ? 487  VAL A CB    1 ? 
ATOM   3787 C CG1   . VAL A 1 508 ? -7.335  13.676  32.640 1.00 21.80  ? 487  VAL A CG1   1 ? 
ATOM   3788 C CG2   . VAL A 1 508 ? -9.063  12.370  31.318 1.00 19.97  ? 487  VAL A CG2   1 ? 
ATOM   3789 N N     . ASP A 1 509 ? -11.739 14.499  32.839 1.00 22.85  ? 488  ASP A N     1 ? 
ATOM   3790 C CA    . ASP A 1 509 ? -13.146 14.539  32.487 1.00 21.34  ? 488  ASP A CA    1 ? 
ATOM   3791 C C     . ASP A 1 509 ? -13.287 14.274  30.996 1.00 21.83  ? 488  ASP A C     1 ? 
ATOM   3792 O O     . ASP A 1 509 ? -12.294 13.956  30.319 1.00 20.45  ? 488  ASP A O     1 ? 
ATOM   3793 C CB    . ASP A 1 509 ? -13.805 15.829  32.964 1.00 23.99  ? 488  ASP A CB    1 ? 
ATOM   3794 C CG    . ASP A 1 509 ? -13.277 17.120  32.339 1.00 25.83  ? 488  ASP A CG    1 ? 
ATOM   3795 O OD1   . ASP A 1 509 ? -12.648 17.055  31.266 1.00 24.16  ? 488  ASP A OD1   1 ? 
ATOM   3796 O OD2   . ASP A 1 509 ? -13.479 18.180  32.931 1.00 26.90  ? 488  ASP A OD2   1 ? 
ATOM   3797 N N     . SER A 1 510 ? -14.522 14.450  30.511 1.00 21.29  ? 489  SER A N     1 ? 
ATOM   3798 C CA    . SER A 1 510 ? -14.915 14.275  29.120 1.00 26.10  ? 489  SER A CA    1 ? 
ATOM   3799 C C     . SER A 1 510 ? -14.180 15.233  28.183 1.00 24.87  ? 489  SER A C     1 ? 
ATOM   3800 O O     . SER A 1 510 ? -14.182 15.002  26.976 1.00 21.46  ? 489  SER A O     1 ? 
ATOM   3801 C CB    . SER A 1 510 ? -16.415 14.513  28.968 1.00 28.33  ? 489  SER A CB    1 ? 
ATOM   3802 O OG    . SER A 1 510 ? -17.084 13.399  29.534 1.00 45.57  ? 489  SER A OG    1 ? 
ATOM   3803 N N     . SER A 1 511 ? -13.691 16.351  28.732 1.00 24.02  ? 490  SER A N     1 ? 
ATOM   3804 C CA    . SER A 1 511 ? -12.870 17.303  27.981 1.00 25.61  ? 490  SER A CA    1 ? 
ATOM   3805 C C     . SER A 1 511 ? -11.360 17.059  28.120 1.00 25.59  ? 490  SER A C     1 ? 
ATOM   3806 O O     . SER A 1 511 ? -10.555 17.825  27.594 1.00 21.71  ? 490  SER A O     1 ? 
ATOM   3807 C CB    . SER A 1 511 ? -13.225 18.705  28.389 1.00 27.10  ? 490  SER A CB    1 ? 
ATOM   3808 O OG    . SER A 1 511 ? -14.431 19.021  27.722 1.00 29.88  ? 490  SER A OG    1 ? 
ATOM   3809 N N     . LEU A 1 512 ? -10.984 15.982  28.819 1.00 24.79  ? 491  LEU A N     1 ? 
ATOM   3810 C CA    . LEU A 1 512 ? -9.603  15.557  28.984 1.00 23.45  ? 491  LEU A CA    1 ? 
ATOM   3811 C C     . LEU A 1 512 ? -8.882  16.447  29.997 1.00 23.69  ? 491  LEU A C     1 ? 
ATOM   3812 O O     . LEU A 1 512 ? -7.670  16.358  30.124 1.00 23.64  ? 491  LEU A O     1 ? 
ATOM   3813 C CB    . LEU A 1 512 ? -8.845  15.447  27.659 1.00 22.57  ? 491  LEU A CB    1 ? 
ATOM   3814 C CG    . LEU A 1 512 ? -9.466  14.496  26.627 1.00 21.67  ? 491  LEU A CG    1 ? 
ATOM   3815 C CD1   . LEU A 1 512 ? -8.757  14.544  25.316 1.00 22.43  ? 491  LEU A CD1   1 ? 
ATOM   3816 C CD2   . LEU A 1 512 ? -9.472  13.082  27.160 1.00 21.52  ? 491  LEU A CD2   1 ? 
ATOM   3817 N N     . LYS A 1 513 ? -9.623  17.272  30.752 1.00 24.39  ? 492  LYS A N     1 ? 
ATOM   3818 C CA    . LYS A 1 513 ? -9.036  18.127  31.759 1.00 23.30  ? 492  LYS A CA    1 ? 
ATOM   3819 C C     . LYS A 1 513 ? -8.813  17.353  33.052 1.00 22.51  ? 492  LYS A C     1 ? 
ATOM   3820 O O     . LYS A 1 513 ? -9.709  16.671  33.543 1.00 22.94  ? 492  LYS A O     1 ? 
ATOM   3821 C CB    . LYS A 1 513 ? -9.942  19.325  32.080 1.00 26.97  ? 492  LYS A CB    1 ? 
ATOM   3822 C CG    . LYS A 1 513 ? -10.096 20.274  30.915 1.00 30.86  ? 492  LYS A CG    1 ? 
ATOM   3823 C CD    . LYS A 1 513 ? -10.994 21.448  31.245 1.00 38.38  ? 492  LYS A CD    1 ? 
ATOM   3824 C CE    . LYS A 1 513 ? -11.236 22.267  30.020 1.00 45.06  ? 492  LYS A CE    1 ? 
ATOM   3825 N NZ    . LYS A 1 513 ? -12.041 23.433  30.399 1.00 52.70  ? 492  LYS A NZ    1 ? 
ATOM   3826 N N     . VAL A 1 514 ? -7.627  17.553  33.613 1.00 21.54  ? 493  VAL A N     1 ? 
ATOM   3827 C CA    . VAL A 1 514 ? -7.232  16.924  34.861 1.00 22.96  ? 493  VAL A CA    1 ? 
ATOM   3828 C C     . VAL A 1 514 ? -7.985  17.593  35.999 1.00 26.50  ? 493  VAL A C     1 ? 
ATOM   3829 O O     . VAL A 1 514 ? -8.022  18.820  36.139 1.00 25.13  ? 493  VAL A O     1 ? 
ATOM   3830 C CB    . VAL A 1 514 ? -5.713  17.012  35.071 1.00 24.05  ? 493  VAL A CB    1 ? 
ATOM   3831 C CG1   . VAL A 1 514 ? -5.265  16.590  36.463 1.00 23.80  ? 493  VAL A CG1   1 ? 
ATOM   3832 C CG2   . VAL A 1 514 ? -4.964  16.231  33.989 1.00 24.21  ? 493  VAL A CG2   1 ? 
ATOM   3833 N N     . ARG A 1 515 ? -8.610  16.733  36.784 1.00 24.73  ? 494  ARG A N     1 ? 
ATOM   3834 C CA    . ARG A 1 515 ? -9.323  17.133  37.977 1.00 27.36  ? 494  ARG A CA    1 ? 
ATOM   3835 C C     . ARG A 1 515 ? -8.436  17.870  38.970 1.00 22.77  ? 494  ARG A C     1 ? 
ATOM   3836 O O     . ARG A 1 515 ? -7.306  17.493  39.223 1.00 21.72  ? 494  ARG A O     1 ? 
ATOM   3837 C CB    . ARG A 1 515 ? -9.784  15.760  38.453 1.00 33.33  ? 494  ARG A CB    1 ? 
ATOM   3838 C CG    . ARG A 1 515 ? -9.654  15.362  39.899 1.00 33.02  ? 494  ARG A CG    1 ? 
ATOM   3839 C CD    . ARG A 1 515 ? -10.337 14.036  39.948 1.00 33.40  ? 494  ARG A CD    1 ? 
ATOM   3840 N NE    . ARG A 1 515 ? -11.391 14.169  40.947 1.00 32.13  ? 494  ARG A NE    1 ? 
ATOM   3841 C CZ    . ARG A 1 515 ? -12.373 13.311  41.111 1.00 32.49  ? 494  ARG A CZ    1 ? 
ATOM   3842 N NH1   . ARG A 1 515 ? -12.458 12.215  40.373 1.00 23.88  ? 494  ARG A NH1   1 ? 
ATOM   3843 N NH2   . ARG A 1 515 ? -13.301 13.586  42.007 1.00 31.89  ? 494  ARG A NH2   1 ? 
ATOM   3844 N N     . GLY A 1 516 ? -8.989  18.913  39.583 1.00 24.04  ? 495  GLY A N     1 ? 
ATOM   3845 C CA    . GLY A 1 516 ? -8.322  19.650  40.644 1.00 24.96  ? 495  GLY A CA    1 ? 
ATOM   3846 C C     . GLY A 1 516 ? -7.370  20.716  40.089 1.00 25.78  ? 495  GLY A C     1 ? 
ATOM   3847 O O     . GLY A 1 516 ? -6.705  21.428  40.844 1.00 28.27  ? 495  GLY A O     1 ? 
ATOM   3848 N N     . ILE A 1 517 ? -7.287  20.817  38.763 1.00 25.83  ? 496  ILE A N     1 ? 
ATOM   3849 C CA    . ILE A 1 517 ? -6.258  21.601  38.105 1.00 25.86  ? 496  ILE A CA    1 ? 
ATOM   3850 C C     . ILE A 1 517 ? -6.915  22.377  36.977 1.00 26.01  ? 496  ILE A C     1 ? 
ATOM   3851 O O     . ILE A 1 517 ? -7.837  21.865  36.326 1.00 24.74  ? 496  ILE A O     1 ? 
ATOM   3852 C CB    . ILE A 1 517 ? -5.152  20.683  37.553 1.00 26.04  ? 496  ILE A CB    1 ? 
ATOM   3853 C CG1   . ILE A 1 517 ? -4.483  19.861  38.643 1.00 28.10  ? 496  ILE A CG1   1 ? 
ATOM   3854 C CG2   . ILE A 1 517 ? -4.133  21.475  36.748 1.00 25.40  ? 496  ILE A CG2   1 ? 
ATOM   3855 C CD1   . ILE A 1 517 ? -3.697  20.666  39.652 1.00 29.28  ? 496  ILE A CD1   1 ? 
ATOM   3856 N N     . GLN A 1 518 ? -6.380  23.568  36.687 1.00 25.56  ? 497  GLN A N     1 ? 
ATOM   3857 C CA    . GLN A 1 518 ? -6.797  24.313  35.504 1.00 27.25  ? 497  GLN A CA    1 ? 
ATOM   3858 C C     . GLN A 1 518 ? -5.657  24.337  34.495 1.00 25.31  ? 497  GLN A C     1 ? 
ATOM   3859 O O     . GLN A 1 518 ? -4.516  24.420  34.898 1.00 26.00  ? 497  GLN A O     1 ? 
ATOM   3860 C CB    . GLN A 1 518 ? -7.219  25.747  35.853 1.00 32.69  ? 497  GLN A CB    1 ? 
ATOM   3861 C CG    . GLN A 1 518 ? -8.372  25.820  36.863 1.00 30.74  ? 497  GLN A CG    1 ? 
ATOM   3862 C CD    . GLN A 1 518 ? -7.944  25.502  38.278 1.00 29.03  ? 497  GLN A CD    1 ? 
ATOM   3863 O OE1   . GLN A 1 518 ? -6.946  26.030  38.771 1.00 27.31  ? 497  GLN A OE1   1 ? 
ATOM   3864 N NE2   . GLN A 1 518 ? -8.657  24.621  38.970 1.00 27.98  ? 497  GLN A NE2   1 ? 
ATOM   3865 N N     . GLY A 1 519 ? -5.985  24.258  33.204 1.00 23.17  ? 498  GLY A N     1 ? 
ATOM   3866 C CA    . GLY A 1 519 ? -5.063  24.441  32.092 1.00 25.36  ? 498  GLY A CA    1 ? 
ATOM   3867 C C     . GLY A 1 519 ? -4.164  23.215  31.829 1.00 25.53  ? 498  GLY A C     1 ? 
ATOM   3868 O O     . GLY A 1 519 ? -3.099  23.340  31.219 1.00 26.85  ? 498  GLY A O     1 ? 
ATOM   3869 N N     . LEU A 1 520 ? -4.592  22.029  32.287 1.00 23.44  ? 499  LEU A N     1 ? 
ATOM   3870 C CA    . LEU A 1 520 ? -3.829  20.795  32.079 1.00 22.95  ? 499  LEU A CA    1 ? 
ATOM   3871 C C     . LEU A 1 520 ? -4.751  19.691  31.552 1.00 21.14  ? 499  LEU A C     1 ? 
ATOM   3872 O O     . LEU A 1 520 ? -5.761  19.375  32.194 1.00 21.79  ? 499  LEU A O     1 ? 
ATOM   3873 C CB    . LEU A 1 520 ? -3.185  20.385  33.398 1.00 21.43  ? 499  LEU A CB    1 ? 
ATOM   3874 C CG    . LEU A 1 520 ? -2.378  19.081  33.360 1.00 22.30  ? 499  LEU A CG    1 ? 
ATOM   3875 C CD1   . LEU A 1 520 ? -1.198  19.201  32.398 1.00 22.84  ? 499  LEU A CD1   1 ? 
ATOM   3876 C CD2   . LEU A 1 520 ? -1.963  18.715  34.761 1.00 23.22  ? 499  LEU A CD2   1 ? 
ATOM   3877 N N     . ARG A 1 521 ? -4.420  19.147  30.367 1.00 20.28  ? 500  ARG A N     1 ? 
ATOM   3878 C CA    . ARG A 1 521 ? -5.157  18.028  29.811 1.00 21.18  ? 500  ARG A CA    1 ? 
ATOM   3879 C C     . ARG A 1 521 ? -4.219  16.832  29.563 1.00 23.93  ? 500  ARG A C     1 ? 
ATOM   3880 O O     . ARG A 1 521 ? -3.007  17.011  29.465 1.00 21.78  ? 500  ARG A O     1 ? 
ATOM   3881 C CB    . ARG A 1 521 ? -5.809  18.441  28.487 1.00 23.16  ? 500  ARG A CB    1 ? 
ATOM   3882 C CG    . ARG A 1 521 ? -6.815  19.563  28.679 1.00 23.81  ? 500  ARG A CG    1 ? 
ATOM   3883 C CD    . ARG A 1 521 ? -7.625  19.790  27.439 1.00 28.13  ? 500  ARG A CD    1 ? 
ATOM   3884 N NE    . ARG A 1 521 ? -8.164  21.149  27.449 1.00 28.47  ? 500  ARG A NE    1 ? 
ATOM   3885 C CZ    . ARG A 1 521 ? -9.374  21.540  27.065 1.00 32.64  ? 500  ARG A CZ    1 ? 
ATOM   3886 N NH1   . ARG A 1 521 ? -10.352 20.659  26.863 1.00 25.22  ? 500  ARG A NH1   1 ? 
ATOM   3887 N NH2   . ARG A 1 521 ? -9.607  22.846  26.964 1.00 32.80  ? 500  ARG A NH2   1 ? 
ATOM   3888 N N     . VAL A 1 522 ? -4.812  15.633  29.427 1.00 18.94  ? 501  VAL A N     1 ? 
ATOM   3889 C CA    . VAL A 1 522 ? -4.086  14.429  29.050 1.00 19.09  ? 501  VAL A CA    1 ? 
ATOM   3890 C C     . VAL A 1 522 ? -4.744  13.851  27.810 1.00 19.76  ? 501  VAL A C     1 ? 
ATOM   3891 O O     . VAL A 1 522 ? -5.972  13.736  27.752 1.00 18.73  ? 501  VAL A O     1 ? 
ATOM   3892 C CB    . VAL A 1 522 ? -4.071  13.387  30.173 1.00 17.58  ? 501  VAL A CB    1 ? 
ATOM   3893 C CG1   . VAL A 1 522 ? -3.257  12.137  29.803 1.00 19.03  ? 501  VAL A CG1   1 ? 
ATOM   3894 C CG2   . VAL A 1 522 ? -3.567  13.993  31.458 1.00 16.40  ? 501  VAL A CG2   1 ? 
ATOM   3895 N N     . ALA A 1 523 ? -3.920  13.507  26.819 1.00 18.28  ? 502  ALA A N     1 ? 
ATOM   3896 C CA    . ALA A 1 523 ? -4.420  12.892  25.612 1.00 17.86  ? 502  ALA A CA    1 ? 
ATOM   3897 C C     . ALA A 1 523 ? -3.408  11.896  25.056 1.00 17.63  ? 502  ALA A C     1 ? 
ATOM   3898 O O     . ALA A 1 523 ? -2.508  12.273  24.306 1.00 17.98  ? 502  ALA A O     1 ? 
ATOM   3899 C CB    . ALA A 1 523 ? -4.755  13.970  24.611 1.00 20.51  ? 502  ALA A CB    1 ? 
ATOM   3900 N N     . ASP A 1 524 ? -3.656  10.616  25.373 1.00 18.82  ? 503  ASP A N     1 ? 
ATOM   3901 C CA    . ASP A 1 524 ? -2.829  9.474   25.015 1.00 19.25  ? 503  ASP A CA    1 ? 
ATOM   3902 C C     . ASP A 1 524 ? -3.534  8.210   25.548 1.00 18.32  ? 503  ASP A C     1 ? 
ATOM   3903 O O     . ASP A 1 524 ? -4.663  8.289   26.024 1.00 18.22  ? 503  ASP A O     1 ? 
ATOM   3904 C CB    . ASP A 1 524 ? -1.415  9.675   25.531 1.00 16.93  ? 503  ASP A CB    1 ? 
ATOM   3905 C CG    . ASP A 1 524 ? -1.254  9.724   27.043 1.00 19.80  ? 503  ASP A CG    1 ? 
ATOM   3906 O OD1   . ASP A 1 524 ? -2.179  9.234   27.757 1.00 20.16  ? 503  ASP A OD1   1 ? 
ATOM   3907 O OD2   . ASP A 1 524 ? -0.216  10.293  27.502 1.00 21.15  ? 503  ASP A OD2   1 ? 
ATOM   3908 N N     . ALA A 1 525 ? -2.843  7.070   25.535 1.00 17.40  ? 504  ALA A N     1 ? 
ATOM   3909 C CA    . ALA A 1 525 ? -3.448  5.804   25.932 1.00 15.70  ? 504  ALA A CA    1 ? 
ATOM   3910 C C     . ALA A 1 525 ? -3.822  5.810   27.411 1.00 16.02  ? 504  ALA A C     1 ? 
ATOM   3911 O O     . ALA A 1 525 ? -4.611  4.978   27.867 1.00 14.45  ? 504  ALA A O     1 ? 
ATOM   3912 C CB    . ALA A 1 525 ? -2.532  4.658   25.625 1.00 15.86  ? 504  ALA A CB    1 ? 
ATOM   3913 N N     . SER A 1 526 ? -3.207  6.694   28.198 1.00 16.18  ? 505  SER A N     1 ? 
ATOM   3914 C CA    . SER A 1 526 ? -3.450  6.684   29.626 1.00 16.74  ? 505  SER A CA    1 ? 
ATOM   3915 C C     . SER A 1 526 ? -4.910  6.984   29.957 1.00 17.51  ? 505  SER A C     1 ? 
ATOM   3916 O O     . SER A 1 526 ? -5.373  6.565   31.028 1.00 17.15  ? 505  SER A O     1 ? 
ATOM   3917 C CB    . SER A 1 526 ? -2.518  7.635   30.372 1.00 16.86  ? 505  SER A CB    1 ? 
ATOM   3918 O OG    . SER A 1 526 ? -2.849  9.005   30.131 1.00 17.51  ? 505  SER A OG    1 ? 
ATOM   3919 N N     . ILE A 1 527 ? -5.620  7.736   29.096 1.00 17.32  ? 506  ILE A N     1 ? 
ATOM   3920 C CA    . ILE A 1 527 ? -6.989  8.139   29.390 1.00 18.73  ? 506  ILE A CA    1 ? 
ATOM   3921 C C     . ILE A 1 527 ? -7.981  7.020   29.033 1.00 17.49  ? 506  ILE A C     1 ? 
ATOM   3922 O O     . ILE A 1 527 ? -9.101  7.013   29.520 1.00 17.28  ? 506  ILE A O     1 ? 
ATOM   3923 C CB    . ILE A 1 527 ? -7.358  9.490   28.737 1.00 20.56  ? 506  ILE A CB    1 ? 
ATOM   3924 C CG1   . ILE A 1 527 ? -7.559  9.425   27.235 1.00 22.71  ? 506  ILE A CG1   1 ? 
ATOM   3925 C CG2   . ILE A 1 527 ? -6.306  10.544  29.059 1.00 19.33  ? 506  ILE A CG2   1 ? 
ATOM   3926 C CD1   . ILE A 1 527 ? -8.933  9.000   26.774 1.00 24.00  ? 506  ILE A CD1   1 ? 
ATOM   3927 N N     . ILE A 1 528 ? -7.550  6.052   28.223 1.00 17.05  ? 507  ILE A N     1 ? 
ATOM   3928 C CA    . ILE A 1 528 ? -8.418  4.971   27.763 1.00 18.42  ? 507  ILE A CA    1 ? 
ATOM   3929 C C     . ILE A 1 528 ? -8.776  4.099   28.964 1.00 19.48  ? 507  ILE A C     1 ? 
ATOM   3930 O O     . ILE A 1 528 ? -7.879  3.618   29.631 1.00 19.23  ? 507  ILE A O     1 ? 
ATOM   3931 C CB    . ILE A 1 528 ? -7.725  4.161   26.662 1.00 18.61  ? 507  ILE A CB    1 ? 
ATOM   3932 C CG1   . ILE A 1 528 ? -7.519  5.059   25.435 1.00 19.78  ? 507  ILE A CG1   1 ? 
ATOM   3933 C CG2   . ILE A 1 528 ? -8.513  2.866   26.362 1.00 18.22  ? 507  ILE A CG2   1 ? 
ATOM   3934 C CD1   . ILE A 1 528 ? -6.837  4.387   24.260 1.00 20.10  ? 507  ILE A CD1   1 ? 
ATOM   3935 N N     . PRO A 1 529 ? -10.075 3.917   29.305 1.00 23.23  ? 508  PRO A N     1 ? 
ATOM   3936 C CA    . PRO A 1 529 ? -10.461 3.210   30.535 1.00 22.50  ? 508  PRO A CA    1 ? 
ATOM   3937 C C     . PRO A 1 529 ? -10.065 1.740   30.586 1.00 21.31  ? 508  PRO A C     1 ? 
ATOM   3938 O O     . PRO A 1 529 ? -9.693  1.230   31.641 1.00 23.34  ? 508  PRO A O     1 ? 
ATOM   3939 C CB    . PRO A 1 529 ? -11.982 3.417   30.597 1.00 22.84  ? 508  PRO A CB    1 ? 
ATOM   3940 C CG    . PRO A 1 529 ? -12.266 4.562   29.683 1.00 26.00  ? 508  PRO A CG    1 ? 
ATOM   3941 C CD    . PRO A 1 529 ? -11.227 4.481   28.589 1.00 24.65  ? 508  PRO A CD    1 ? 
ATOM   3942 N N     . ALA A 1 530 ? -10.149 1.069   29.432 1.00 20.70  ? 509  ALA A N     1 ? 
ATOM   3943 C CA    . ALA A 1 530 ? -9.899  -0.352  29.354 1.00 22.73  ? 509  ALA A CA    1 ? 
ATOM   3944 C C     . ALA A 1 530 ? -9.443  -0.706  27.943 1.00 22.56  ? 509  ALA A C     1 ? 
ATOM   3945 O O     . ALA A 1 530 ? -9.829  -0.074  26.967 1.00 22.87  ? 509  ALA A O     1 ? 
ATOM   3946 C CB    . ALA A 1 530 ? -11.148 -1.118  29.739 1.00 22.52  ? 509  ALA A CB    1 ? 
ATOM   3947 N N     . VAL A 1 531 ? -8.646  -1.769  27.866 1.00 21.82  ? 510  VAL A N     1 ? 
ATOM   3948 C CA    . VAL A 1 531 ? -8.138  -2.229  26.595 1.00 24.00  ? 510  VAL A CA    1 ? 
ATOM   3949 C C     . VAL A 1 531 ? -9.318  -2.561  25.678 1.00 26.70  ? 510  VAL A C     1 ? 
ATOM   3950 O O     . VAL A 1 531 ? -10.405 -2.914  26.148 1.00 25.17  ? 510  VAL A O     1 ? 
ATOM   3951 C CB    . VAL A 1 531 ? -7.176  -3.415  26.765 1.00 22.53  ? 510  VAL A CB    1 ? 
ATOM   3952 C CG1   . VAL A 1 531 ? -5.844  -2.971  27.344 1.00 24.34  ? 510  VAL A CG1   1 ? 
ATOM   3953 C CG2   . VAL A 1 531 ? -7.809  -4.563  27.557 1.00 22.90  ? 510  VAL A CG2   1 ? 
ATOM   3954 N N     . ASN A 1 532 ? -9.089  -2.438  24.360 1.00 26.04  ? 511  ASN A N     1 ? 
ATOM   3955 C CA    . ASN A 1 532 ? -10.148 -2.692  23.380 1.00 25.44  ? 511  ASN A CA    1 ? 
ATOM   3956 C C     . ASN A 1 532 ? -10.129 -4.173  22.964 1.00 24.15  ? 511  ASN A C     1 ? 
ATOM   3957 O O     . ASN A 1 532 ? -9.266  -4.952  23.397 1.00 24.19  ? 511  ASN A O     1 ? 
ATOM   3958 C CB    . ASN A 1 532 ? -10.000 -1.721  22.211 1.00 25.11  ? 511  ASN A CB    1 ? 
ATOM   3959 C CG    . ASN A 1 532 ? -8.643  -1.769  21.540 1.00 26.89  ? 511  ASN A CG    1 ? 
ATOM   3960 O OD1   . ASN A 1 532 ? -7.617  -2.043  22.184 1.00 24.34  ? 511  ASN A OD1   1 ? 
ATOM   3961 N ND2   . ASN A 1 532 ? -8.617  -1.549  20.229 1.00 26.02  ? 511  ASN A ND2   1 ? 
ATOM   3962 N N     . ARG A 1 533 ? -11.082 -4.549  22.093 1.00 23.05  ? 512  ARG A N     1 ? 
ATOM   3963 C CA    . ARG A 1 533 ? -11.077 -5.826  21.399 1.00 22.67  ? 512  ARG A CA    1 ? 
ATOM   3964 C C     . ARG A 1 533 ? -10.257 -5.653  20.128 1.00 24.93  ? 512  ARG A C     1 ? 
ATOM   3965 O O     . ARG A 1 533 ? -10.766 -5.600  19.018 1.00 24.24  ? 512  ARG A O     1 ? 
ATOM   3966 C CB    . ARG A 1 533 ? -12.516 -6.278  21.124 1.00 24.91  ? 512  ARG A CB    1 ? 
ATOM   3967 C CG    . ARG A 1 533 ? -13.295 -6.526  22.410 1.00 25.90  ? 512  ARG A CG    1 ? 
ATOM   3968 C CD    . ARG A 1 533 ? -14.773 -6.758  22.147 1.00 25.99  ? 512  ARG A CD    1 ? 
ATOM   3969 N NE    . ARG A 1 533 ? -15.473 -7.205  23.348 1.00 29.10  ? 512  ARG A NE    1 ? 
ATOM   3970 C CZ    . ARG A 1 533 ? -15.983 -6.432  24.285 1.00 30.89  ? 512  ARG A CZ    1 ? 
ATOM   3971 N NH1   . ARG A 1 533 ? -15.867 -5.124  24.209 1.00 29.56  ? 512  ARG A NH1   1 ? 
ATOM   3972 N NH2   . ARG A 1 533 ? -16.654 -6.974  25.296 1.00 34.08  ? 512  ARG A NH2   1 ? 
ATOM   3973 N N     . GLY A 1 534 ? -8.960  -5.531  20.327 1.00 24.14  ? 513  GLY A N     1 ? 
ATOM   3974 C CA    . GLY A 1 534 ? -8.048  -5.098  19.292 1.00 25.76  ? 513  GLY A CA    1 ? 
ATOM   3975 C C     . GLY A 1 534 ? -6.746  -4.598  19.904 1.00 24.61  ? 513  GLY A C     1 ? 
ATOM   3976 O O     . GLY A 1 534 ? -6.348  -5.043  20.989 1.00 25.05  ? 513  GLY A O     1 ? 
ATOM   3977 N N     . HIS A 1 535 ? -6.129  -3.662  19.179 1.00 22.88  ? 514  HIS A N     1 ? 
ATOM   3978 C CA    . HIS A 1 535 ? -4.817  -3.150  19.485 1.00 20.47  ? 514  HIS A CA    1 ? 
ATOM   3979 C C     . HIS A 1 535 ? -4.929  -1.636  19.620 1.00 19.26  ? 514  HIS A C     1 ? 
ATOM   3980 O O     . HIS A 1 535 ? -5.743  -1.028  18.924 1.00 19.85  ? 514  HIS A O     1 ? 
ATOM   3981 C CB    . HIS A 1 535 ? -3.842  -3.622  18.403 1.00 20.99  ? 514  HIS A CB    1 ? 
ATOM   3982 C CG    . HIS A 1 535 ? -3.806  -5.103  18.126 1.00 22.42  ? 514  HIS A CG    1 ? 
ATOM   3983 N ND1   . HIS A 1 535 ? -2.614  -5.798  18.084 1.00 24.29  ? 514  HIS A ND1   1 ? 
ATOM   3984 C CD2   . HIS A 1 535 ? -4.762  -6.014  17.920 1.00 24.22  ? 514  HIS A CD2   1 ? 
ATOM   3985 C CE1   . HIS A 1 535 ? -2.870  -7.076  17.819 1.00 25.37  ? 514  HIS A CE1   1 ? 
ATOM   3986 N NE2   . HIS A 1 535 ? -4.167  -7.222  17.699 1.00 23.11  ? 514  HIS A NE2   1 ? 
ATOM   3987 N N     . THR A 1 536 ? -4.057  -1.018  20.431 1.00 18.69  ? 515  THR A N     1 ? 
ATOM   3988 C CA    . THR A 1 536 ? -4.362  0.297   20.986 1.00 20.30  ? 515  THR A CA    1 ? 
ATOM   3989 C C     . THR A 1 536 ? -3.894  1.486   20.135 1.00 19.70  ? 515  THR A C     1 ? 
ATOM   3990 O O     . THR A 1 536 ? -4.247  2.605   20.449 1.00 20.40  ? 515  THR A O     1 ? 
ATOM   3991 C CB    . THR A 1 536 ? -3.835  0.396   22.423 1.00 18.75  ? 515  THR A CB    1 ? 
ATOM   3992 O OG1   . THR A 1 536 ? -2.506  -0.133  22.497 1.00 17.92  ? 515  THR A OG1   1 ? 
ATOM   3993 C CG2   . THR A 1 536 ? -4.756  -0.351  23.375 1.00 20.75  ? 515  THR A CG2   1 ? 
ATOM   3994 N N     . MET A 1 537 ? -3.146  1.296   19.052 1.00 21.45  ? 516  MET A N     1 ? 
ATOM   3995 C CA    . MET A 1 537 ? -2.715  2.431   18.232 1.00 19.85  ? 516  MET A CA    1 ? 
ATOM   3996 C C     . MET A 1 537 ? -3.905  3.207   17.660 1.00 19.06  ? 516  MET A C     1 ? 
ATOM   3997 O O     . MET A 1 537 ? -3.973  4.449   17.736 1.00 17.68  ? 516  MET A O     1 ? 
ATOM   3998 C CB    . MET A 1 537 ? -1.794  1.947   17.101 1.00 20.93  ? 516  MET A CB    1 ? 
ATOM   3999 C CG    . MET A 1 537 ? -1.255  3.064   16.240 1.00 23.62  ? 516  MET A CG    1 ? 
ATOM   4000 S SD    . MET A 1 537 ? 0.021   2.603   15.056 1.00 22.82  ? 516  MET A SD    1 ? 
ATOM   4001 C CE    . MET A 1 537 ? -0.608  1.095   14.310 1.00 23.41  ? 516  MET A CE    1 ? 
ATOM   4002 N N     . ALA A 1 538 ? -4.894  2.476   17.146 1.00 18.59  ? 517  ALA A N     1 ? 
ATOM   4003 C CA    . ALA A 1 538 ? -6.022  3.100   16.472 1.00 21.00  ? 517  ALA A CA    1 ? 
ATOM   4004 C C     . ALA A 1 538 ? -6.876  3.936   17.430 1.00 19.79  ? 517  ALA A C     1 ? 
ATOM   4005 O O     . ALA A 1 538 ? -7.113  5.118   17.166 1.00 21.44  ? 517  ALA A O     1 ? 
ATOM   4006 C CB    . ALA A 1 538 ? -6.825  2.045   15.762 1.00 19.68  ? 517  ALA A CB    1 ? 
ATOM   4007 N N     . PRO A 1 539 ? -7.360  3.399   18.583 1.00 18.79  ? 518  PRO A N     1 ? 
ATOM   4008 C CA    . PRO A 1 539 ? -8.053  4.246   19.547 1.00 17.80  ? 518  PRO A CA    1 ? 
ATOM   4009 C C     . PRO A 1 539 ? -7.197  5.424   20.046 1.00 17.57  ? 518  PRO A C     1 ? 
ATOM   4010 O O     . PRO A 1 539 ? -7.750  6.486   20.331 1.00 19.28  ? 518  PRO A O     1 ? 
ATOM   4011 C CB    . PRO A 1 539 ? -8.484  3.301   20.677 1.00 17.46  ? 518  PRO A CB    1 ? 
ATOM   4012 C CG    . PRO A 1 539 ? -7.631  2.057   20.454 1.00 17.85  ? 518  PRO A CG    1 ? 
ATOM   4013 C CD    . PRO A 1 539 ? -7.326  1.977   18.984 1.00 17.59  ? 518  PRO A CD    1 ? 
ATOM   4014 N N     . VAL A 1 540 ? -5.872  5.279   20.090 1.00 17.98  ? 519  VAL A N     1 ? 
ATOM   4015 C CA    . VAL A 1 540 ? -5.019  6.401   20.518 1.00 18.89  ? 519  VAL A CA    1 ? 
ATOM   4016 C C     . VAL A 1 540 ? -5.048  7.554   19.502 1.00 19.25  ? 519  VAL A C     1 ? 
ATOM   4017 O O     . VAL A 1 540 ? -5.103  8.718   19.888 1.00 20.63  ? 519  VAL A O     1 ? 
ATOM   4018 C CB    . VAL A 1 540 ? -3.573  5.983   20.825 1.00 19.39  ? 519  VAL A CB    1 ? 
ATOM   4019 C CG1   . VAL A 1 540 ? -2.674  7.192   21.057 1.00 18.40  ? 519  VAL A CG1   1 ? 
ATOM   4020 C CG2   . VAL A 1 540 ? -3.492  5.071   22.050 1.00 20.65  ? 519  VAL A CG2   1 ? 
ATOM   4021 N N     . VAL A 1 541 ? -5.023  7.235   18.200 1.00 21.02  ? 520  VAL A N     1 ? 
ATOM   4022 C CA    . VAL A 1 541 ? -5.156  8.255   17.160 1.00 22.20  ? 520  VAL A CA    1 ? 
ATOM   4023 C C     . VAL A 1 541 ? -6.532  8.905   17.266 1.00 21.10  ? 520  VAL A C     1 ? 
ATOM   4024 O O     . VAL A 1 541 ? -6.634  10.129  17.192 1.00 21.29  ? 520  VAL A O     1 ? 
ATOM   4025 C CB    . VAL A 1 541 ? -4.896  7.694   15.750 1.00 20.79  ? 520  VAL A CB    1 ? 
ATOM   4026 C CG1   . VAL A 1 541 ? -5.025  8.775   14.683 1.00 20.13  ? 520  VAL A CG1   1 ? 
ATOM   4027 C CG2   . VAL A 1 541 ? -3.530  7.066   15.693 1.00 20.67  ? 520  VAL A CG2   1 ? 
ATOM   4028 N N     . TYR A 1 542 ? -7.576  8.092   17.518 1.00 20.02  ? 521  TYR A N     1 ? 
ATOM   4029 C CA    . TYR A 1 542 ? -8.909  8.618   17.810 1.00 20.43  ? 521  TYR A CA    1 ? 
ATOM   4030 C C     . TYR A 1 542 ? -8.855  9.635   18.955 1.00 20.76  ? 521  TYR A C     1 ? 
ATOM   4031 O O     . TYR A 1 542 ? -9.481  10.685  18.874 1.00 22.65  ? 521  TYR A O     1 ? 
ATOM   4032 C CB    . TYR A 1 542 ? -9.868  7.449   18.055 1.00 19.47  ? 521  TYR A CB    1 ? 
ATOM   4033 C CG    . TYR A 1 542 ? -11.160 7.721   18.815 1.00 19.22  ? 521  TYR A CG    1 ? 
ATOM   4034 C CD1   . TYR A 1 542 ? -12.196 8.489   18.275 1.00 18.86  ? 521  TYR A CD1   1 ? 
ATOM   4035 C CD2   . TYR A 1 542 ? -11.367 7.156   20.061 1.00 19.08  ? 521  TYR A CD2   1 ? 
ATOM   4036 C CE1   . TYR A 1 542 ? -13.363 8.734   18.988 1.00 20.48  ? 521  TYR A CE1   1 ? 
ATOM   4037 C CE2   . TYR A 1 542 ? -12.532 7.359   20.767 1.00 19.59  ? 521  TYR A CE2   1 ? 
ATOM   4038 C CZ    . TYR A 1 542 ? -13.545 8.140   20.225 1.00 20.73  ? 521  TYR A CZ    1 ? 
ATOM   4039 O OH    . TYR A 1 542 ? -14.698 8.272   20.938 1.00 19.70  ? 521  TYR A OH    1 ? 
ATOM   4040 N N     . VAL A 1 543 ? -8.172  9.292   20.047 1.00 18.76  ? 522  VAL A N     1 ? 
ATOM   4041 C CA    . VAL A 1 543 ? -8.038  10.207  21.167 1.00 20.38  ? 522  VAL A CA    1 ? 
ATOM   4042 C C     . VAL A 1 543 ? -7.402  11.524  20.700 1.00 20.33  ? 522  VAL A C     1 ? 
ATOM   4043 O O     . VAL A 1 543 ? -7.824  12.593  21.129 1.00 18.92  ? 522  VAL A O     1 ? 
ATOM   4044 C CB    . VAL A 1 543 ? -7.228  9.561   22.310 1.00 20.03  ? 522  VAL A CB    1 ? 
ATOM   4045 C CG1   . VAL A 1 543 ? -6.761  10.572  23.343 1.00 21.17  ? 522  VAL A CG1   1 ? 
ATOM   4046 C CG2   . VAL A 1 543 ? -7.988  8.445   23.010 1.00 20.99  ? 522  VAL A CG2   1 ? 
ATOM   4047 N N     . GLY A 1 544 ? -6.386  11.455  19.827 1.00 19.05  ? 523  GLY A N     1 ? 
ATOM   4048 C CA    . GLY A 1 544 ? -5.721  12.670  19.362 1.00 20.48  ? 523  GLY A CA    1 ? 
ATOM   4049 C C     . GLY A 1 544 ? -6.671  13.563  18.550 1.00 22.50  ? 523  GLY A C     1 ? 
ATOM   4050 O O     . GLY A 1 544 ? -6.696  14.777  18.743 1.00 22.23  ? 523  GLY A O     1 ? 
ATOM   4051 N N     . GLU A 1 545 ? -7.475  12.954  17.663 1.00 22.15  ? 524  GLU A N     1 ? 
ATOM   4052 C CA    . GLU A 1 545 ? -8.429  13.697  16.849 1.00 22.94  ? 524  GLU A CA    1 ? 
ATOM   4053 C C     . GLU A 1 545 ? -9.525  14.287  17.746 1.00 23.46  ? 524  GLU A C     1 ? 
ATOM   4054 O O     . GLU A 1 545 ? -9.937  15.435  17.567 1.00 22.73  ? 524  GLU A O     1 ? 
ATOM   4055 C CB    . GLU A 1 545 ? -9.019  12.789  15.766 1.00 21.97  ? 524  GLU A CB    1 ? 
ATOM   4056 C CG    . GLU A 1 545 ? -8.112  12.498  14.581 1.00 22.41  ? 524  GLU A CG    1 ? 
ATOM   4057 C CD    . GLU A 1 545 ? -7.818  13.667  13.647 1.00 22.72  ? 524  GLU A CD    1 ? 
ATOM   4058 O OE1   . GLU A 1 545 ? -7.328  13.358  12.559 1.00 26.09  ? 524  GLU A OE1   1 ? 
ATOM   4059 O OE2   . GLU A 1 545 ? -8.026  14.849  13.998 1.00 25.73  ? 524  GLU A OE2   1 ? 
ATOM   4060 N N     . MET A 1 546 ? -9.967  13.506  18.746 1.00 22.85  ? 525  MET A N     1 ? 
ATOM   4061 C CA    . MET A 1 546 ? -10.987 13.956  19.673 1.00 22.32  ? 525  MET A CA    1 ? 
ATOM   4062 C C     . MET A 1 546 ? -10.485 15.125  20.525 1.00 23.65  ? 525  MET A C     1 ? 
ATOM   4063 O O     . MET A 1 546 ? -11.193 16.136  20.693 1.00 24.99  ? 525  MET A O     1 ? 
ATOM   4064 C CB    . MET A 1 546 ? -11.501 12.805  20.540 1.00 22.91  ? 525  MET A CB    1 ? 
ATOM   4065 C CG    . MET A 1 546 ? -12.325 11.791  19.782 1.00 24.63  ? 525  MET A CG    1 ? 
ATOM   4066 S SD    . MET A 1 546 ? -14.001 12.400  19.444 1.00 24.68  ? 525  MET A SD    1 ? 
ATOM   4067 C CE    . MET A 1 546 ? -14.712 12.111  21.065 1.00 21.15  ? 525  MET A CE    1 ? 
ATOM   4068 N N     . ALA A 1 547 ? -9.267  15.001  21.069 1.00 21.18  ? 526  ALA A N     1 ? 
ATOM   4069 C CA    . ALA A 1 547 ? -8.684  16.053  21.886 1.00 21.93  ? 526  ALA A CA    1 ? 
ATOM   4070 C C     . ALA A 1 547 ? -8.602  17.360  21.104 1.00 24.90  ? 526  ALA A C     1 ? 
ATOM   4071 O O     . ALA A 1 547 ? -8.897  18.429  21.655 1.00 26.25  ? 526  ALA A O     1 ? 
ATOM   4072 C CB    . ALA A 1 547 ? -7.312  15.642  22.352 1.00 21.88  ? 526  ALA A CB    1 ? 
ATOM   4073 N N     . SER A 1 548 ? -8.185  17.247  19.840 1.00 22.35  ? 527  SER A N     1 ? 
ATOM   4074 C CA    . SER A 1 548 ? -8.011  18.396  18.977 1.00 24.89  ? 527  SER A CA    1 ? 
ATOM   4075 C C     . SER A 1 548 ? -9.340  19.146  18.815 1.00 27.18  ? 527  SER A C     1 ? 
ATOM   4076 O O     . SER A 1 548 ? -9.390  20.361  19.014 1.00 25.30  ? 527  SER A O     1 ? 
ATOM   4077 C CB    . SER A 1 548 ? -7.503  17.965  17.647 1.00 27.10  ? 527  SER A CB    1 ? 
ATOM   4078 O OG    . SER A 1 548 ? -6.245  17.318  17.725 1.00 22.92  ? 527  SER A OG    1 ? 
ATOM   4079 N N     . GLU A 1 549 ? -10.415 18.399  18.493 1.00 25.96  ? 528  GLU A N     1 ? 
ATOM   4080 C CA    . GLU A 1 549 ? -11.741 18.981  18.300 1.00 27.42  ? 528  GLU A CA    1 ? 
ATOM   4081 C C     . GLU A 1 549 ? -12.251 19.617  19.590 1.00 27.32  ? 528  GLU A C     1 ? 
ATOM   4082 O O     . GLU A 1 549 ? -12.840 20.706  19.583 1.00 25.58  ? 528  GLU A O     1 ? 
ATOM   4083 C CB    . GLU A 1 549 ? -12.666 17.949  17.639 1.00 33.08  ? 528  GLU A CB    1 ? 
ATOM   4084 C CG    . GLU A 1 549 ? -14.150 18.326  17.583 1.00 33.79  ? 528  GLU A CG    1 ? 
ATOM   4085 C CD    . GLU A 1 549 ? -15.020 17.236  16.956 1.00 37.26  ? 528  GLU A CD    1 ? 
ATOM   4086 O OE1   . GLU A 1 549 ? -14.938 17.028  15.731 1.00 42.55  ? 528  GLU A OE1   1 ? 
ATOM   4087 O OE2   . GLU A 1 549 ? -15.735 16.536  17.697 1.00 38.16  ? 528  GLU A OE2   1 ? 
ATOM   4088 N N     . ILE A 1 550 ? -12.059 18.931  20.717 1.00 24.32  ? 529  ILE A N     1 ? 
ATOM   4089 C CA    . ILE A 1 550 ? -12.490 19.430  21.999 1.00 22.80  ? 529  ILE A CA    1 ? 
ATOM   4090 C C     . ILE A 1 550 ? -11.782 20.748  22.321 1.00 27.44  ? 529  ILE A C     1 ? 
ATOM   4091 O O     . ILE A 1 550 ? -12.408 21.709  22.764 1.00 29.69  ? 529  ILE A O     1 ? 
ATOM   4092 C CB    . ILE A 1 550 ? -12.228 18.352  23.078 1.00 22.34  ? 529  ILE A CB    1 ? 
ATOM   4093 C CG1   . ILE A 1 550 ? -13.246 17.211  22.946 1.00 23.34  ? 529  ILE A CG1   1 ? 
ATOM   4094 C CG2   . ILE A 1 550 ? -12.226 18.964  24.471 1.00 23.74  ? 529  ILE A CG2   1 ? 
ATOM   4095 C CD1   . ILE A 1 550 ? -12.818 15.903  23.588 1.00 24.70  ? 529  ILE A CD1   1 ? 
ATOM   4096 N N     . ILE A 1 551 ? -10.470 20.782  22.140 1.00 26.67  ? 530  ILE A N     1 ? 
ATOM   4097 C CA    . ILE A 1 551 ? -9.708  21.968  22.506 1.00 31.07  ? 530  ILE A CA    1 ? 
ATOM   4098 C C     . ILE A 1 551 ? -10.097 23.131  21.597 1.00 32.09  ? 530  ILE A C     1 ? 
ATOM   4099 O O     . ILE A 1 551 ? -10.292 24.235  22.087 1.00 35.25  ? 530  ILE A O     1 ? 
ATOM   4100 C CB    . ILE A 1 551 ? -8.193  21.697  22.452 1.00 29.09  ? 530  ILE A CB    1 ? 
ATOM   4101 C CG1   . ILE A 1 551 ? -7.773  20.805  23.612 1.00 28.33  ? 530  ILE A CG1   1 ? 
ATOM   4102 C CG2   . ILE A 1 551 ? -7.378  22.995  22.435 1.00 30.94  ? 530  ILE A CG2   1 ? 
ATOM   4103 C CD1   . ILE A 1 551 ? -6.476  20.051  23.350 1.00 30.50  ? 530  ILE A CD1   1 ? 
ATOM   4104 N N     . ILE A 1 552 ? -10.187 22.879  20.294 1.00 33.46  ? 531  ILE A N     1 ? 
ATOM   4105 C CA    . ILE A 1 552 ? -10.470 23.932  19.340 1.00 38.11  ? 531  ILE A CA    1 ? 
ATOM   4106 C C     . ILE A 1 552 ? -11.834 24.548  19.646 1.00 43.96  ? 531  ILE A C     1 ? 
ATOM   4107 O O     . ILE A 1 552 ? -11.973 25.762  19.530 1.00 43.94  ? 531  ILE A O     1 ? 
ATOM   4108 C CB    . ILE A 1 552 ? -10.347 23.408  17.906 1.00 36.59  ? 531  ILE A CB    1 ? 
ATOM   4109 C CG1   . ILE A 1 552 ? -8.888  23.180  17.564 1.00 36.10  ? 531  ILE A CG1   1 ? 
ATOM   4110 C CG2   . ILE A 1 552 ? -11.020 24.348  16.903 1.00 39.98  ? 531  ILE A CG2   1 ? 
ATOM   4111 C CD1   . ILE A 1 552 ? -8.647  22.348  16.326 1.00 34.46  ? 531  ILE A CD1   1 ? 
ATOM   4112 N N     . ASN A 1 553 ? -12.801 23.728  20.094 1.00 48.41  ? 532  ASN A N     1 ? 
ATOM   4113 C CA    . ASN A 1 553 ? -14.165 24.170  20.359 1.00 53.10  ? 532  ASN A CA    1 ? 
ATOM   4114 C C     . ASN A 1 553 ? -14.303 24.858  21.715 1.00 56.44  ? 532  ASN A C     1 ? 
ATOM   4115 O O     . ASN A 1 553 ? -15.361 25.418  22.006 1.00 58.80  ? 532  ASN A O     1 ? 
ATOM   4116 C CB    . ASN A 1 553 ? -15.170 23.020  20.293 1.00 59.49  ? 532  ASN A CB    1 ? 
ATOM   4117 C CG    . ASN A 1 553 ? -15.447 22.572  18.879 1.00 59.47  ? 532  ASN A CG    1 ? 
ATOM   4118 O OD1   . ASN A 1 553 ? -14.972 23.189  17.917 1.00 62.89  ? 532  ASN A OD1   1 ? 
ATOM   4119 N ND2   . ASN A 1 553 ? -16.208 21.495  18.743 1.00 57.24  ? 532  ASN A ND2   1 ? 
ATOM   4120 N N     . ASP A 1 554 ? -13.274 24.775  22.564 1.00 58.68  ? 533  ASP A N     1 ? 
ATOM   4121 C CA    . ASP A 1 554 ? -13.197 25.597  23.763 1.00 70.02  ? 533  ASP A CA    1 ? 
ATOM   4122 C C     . ASP A 1 554 ? -12.788 27.028  23.398 1.00 74.28  ? 533  ASP A C     1 ? 
ATOM   4123 O O     . ASP A 1 554 ? -13.305 27.984  23.975 1.00 80.02  ? 533  ASP A O     1 ? 
ATOM   4124 C CB    . ASP A 1 554 ? -12.239 25.012  24.792 1.00 72.64  ? 533  ASP A CB    1 ? 
ATOM   4125 C CG    . ASP A 1 554 ? -12.879 24.281  25.964 1.00 82.43  ? 533  ASP A CG    1 ? 
ATOM   4126 O OD1   . ASP A 1 554 ? -13.488 24.982  26.812 1.00 80.81  ? 533  ASP A OD1   1 ? 
ATOM   4127 O OD2   . ASP A 1 554 ? -12.753 23.026  26.025 1.00 76.03  ? 533  ASP A OD2   1 ? 
ATOM   4128 N N     . ASN A 1 555 ? -11.852 27.157  22.444 1.00 80.90  ? 534  ASN A N     1 ? 
ATOM   4129 C CA    . ASN A 1 555 ? -11.200 28.420  22.118 1.00 80.72  ? 534  ASN A CA    1 ? 
ATOM   4130 C C     . ASN A 1 555 ? -11.865 29.035  20.879 1.00 81.23  ? 534  ASN A C     1 ? 
ATOM   4131 O O     . ASN A 1 555 ? -11.136 29.273  19.885 1.00 85.07  ? 534  ASN A O     1 ? 
ATOM   4132 C CB    . ASN A 1 555 ? -9.702  28.226  21.900 1.00 78.98  ? 534  ASN A CB    1 ? 
ATOM   4133 C CG    . ASN A 1 555 ? -9.034  27.547  23.074 1.00 75.46  ? 534  ASN A CG    1 ? 
ATOM   4134 O OD1   . ASN A 1 555 ? -8.692  28.202  24.064 1.00 78.61  ? 534  ASN A OD1   1 ? 
ATOM   4135 N ND2   . ASN A 1 555 ? -8.824  26.243  22.988 1.00 66.36  ? 534  ASN A ND2   1 ? 
ATOM   4136 O OXT   . ASN A 1 555 ? -13.093 29.249  20.947 1.00 75.12  ? 534  ASN A OXT   1 ? 
ATOM   4137 N N     . LYS B 1 22  ? -53.018 -4.913  23.390 1.00 76.80  ? 1    LYS B N     1 ? 
ATOM   4138 C CA    . LYS B 1 22  ? -51.888 -4.151  22.786 1.00 73.12  ? 1    LYS B CA    1 ? 
ATOM   4139 C C     . LYS B 1 22  ? -51.047 -3.533  23.908 1.00 64.06  ? 1    LYS B C     1 ? 
ATOM   4140 O O     . LYS B 1 22  ? -51.588 -2.812  24.752 1.00 49.90  ? 1    LYS B O     1 ? 
ATOM   4141 C CB    . LYS B 1 22  ? -52.475 -3.133  21.802 1.00 73.86  ? 1    LYS B CB    1 ? 
ATOM   4142 C CG    . LYS B 1 22  ? -51.480 -2.340  20.967 1.00 78.02  ? 1    LYS B CG    1 ? 
ATOM   4143 C CD    . LYS B 1 22  ? -52.153 -1.587  19.821 1.00 84.41  ? 1    LYS B CD    1 ? 
ATOM   4144 C CE    . LYS B 1 22  ? -53.118 -0.519  20.249 1.00 84.54  ? 1    LYS B CE    1 ? 
ATOM   4145 N NZ    . LYS B 1 22  ? -54.099 -0.231  19.199 1.00 86.16  ? 1    LYS B NZ    1 ? 
ATOM   4146 N N     . LYS B 1 23  ? -49.734 -3.843  23.907 1.00 51.85  ? 2    LYS B N     1 ? 
ATOM   4147 C CA    . LYS B 1 23  ? -48.871 -3.623  25.060 1.00 50.95  ? 2    LYS B CA    1 ? 
ATOM   4148 C C     . LYS B 1 23  ? -47.755 -2.634  24.719 1.00 46.58  ? 2    LYS B C     1 ? 
ATOM   4149 O O     . LYS B 1 23  ? -47.010 -2.848  23.771 1.00 49.31  ? 2    LYS B O     1 ? 
ATOM   4150 C CB    . LYS B 1 23  ? -48.237 -4.934  25.527 1.00 53.10  ? 2    LYS B CB    1 ? 
ATOM   4151 C CG    . LYS B 1 23  ? -47.915 -4.884  27.005 1.00 64.69  ? 2    LYS B CG    1 ? 
ATOM   4152 C CD    . LYS B 1 23  ? -46.800 -5.816  27.458 1.00 77.21  ? 2    LYS B CD    1 ? 
ATOM   4153 C CE    . LYS B 1 23  ? -46.433 -5.564  28.886 1.00 86.70  ? 2    LYS B CE    1 ? 
ATOM   4154 N NZ    . LYS B 1 23  ? -45.212 -6.283  29.262 1.00 92.53  ? 2    LYS B NZ    1 ? 
ATOM   4155 N N     . PHE B 1 24  ? -47.608 -1.575  25.523 1.00 36.95  ? 3    PHE B N     1 ? 
ATOM   4156 C CA    . PHE B 1 24  ? -46.734 -0.467  25.173 1.00 29.48  ? 3    PHE B CA    1 ? 
ATOM   4157 C C     . PHE B 1 24  ? -45.457 -0.504  26.011 1.00 29.34  ? 3    PHE B C     1 ? 
ATOM   4158 O O     . PHE B 1 24  ? -45.477 -0.836  27.192 1.00 25.28  ? 3    PHE B O     1 ? 
ATOM   4159 C CB    . PHE B 1 24  ? -47.466 0.857   25.389 1.00 29.30  ? 3    PHE B CB    1 ? 
ATOM   4160 C CG    . PHE B 1 24  ? -48.740 0.937   24.572 1.00 28.71  ? 3    PHE B CG    1 ? 
ATOM   4161 C CD1   . PHE B 1 24  ? -48.685 1.039   23.185 1.00 32.20  ? 3    PHE B CD1   1 ? 
ATOM   4162 C CD2   . PHE B 1 24  ? -49.982 0.855   25.191 1.00 33.31  ? 3    PHE B CD2   1 ? 
ATOM   4163 C CE1   . PHE B 1 24  ? -49.850 1.090   22.436 1.00 31.92  ? 3    PHE B CE1   1 ? 
ATOM   4164 C CE2   . PHE B 1 24  ? -51.145 0.904   24.436 1.00 33.22  ? 3    PHE B CE2   1 ? 
ATOM   4165 C CZ    . PHE B 1 24  ? -51.070 1.021   23.063 1.00 31.36  ? 3    PHE B CZ    1 ? 
ATOM   4166 N N     . ASP B 1 25  ? -44.345 -0.188  25.343 1.00 28.83  ? 4    ASP B N     1 ? 
ATOM   4167 C CA    . ASP B 1 25  ? -43.060 0.038   25.973 1.00 27.96  ? 4    ASP B CA    1 ? 
ATOM   4168 C C     . ASP B 1 25  ? -42.988 1.444   26.571 1.00 24.57  ? 4    ASP B C     1 ? 
ATOM   4169 O O     . ASP B 1 25  ? -42.462 1.642   27.670 1.00 26.55  ? 4    ASP B O     1 ? 
ATOM   4170 C CB    . ASP B 1 25  ? -41.968 -0.200  24.948 1.00 31.63  ? 4    ASP B CB    1 ? 
ATOM   4171 C CG    . ASP B 1 25  ? -41.865 -1.659  24.507 1.00 34.96  ? 4    ASP B CG    1 ? 
ATOM   4172 O OD1   . ASP B 1 25  ? -41.480 -2.482  25.353 1.00 37.56  ? 4    ASP B OD1   1 ? 
ATOM   4173 O OD2   . ASP B 1 25  ? -42.275 -1.965  23.374 1.00 34.67  ? 4    ASP B OD2   1 ? 
ATOM   4174 N N     . PHE B 1 26  ? -43.528 2.407   25.830 1.00 24.47  ? 5    PHE B N     1 ? 
ATOM   4175 C CA    . PHE B 1 26  ? -43.455 3.816   26.182 1.00 25.20  ? 5    PHE B CA    1 ? 
ATOM   4176 C C     . PHE B 1 26  ? -44.821 4.467   26.018 1.00 24.47  ? 5    PHE B C     1 ? 
ATOM   4177 O O     . PHE B 1 26  ? -45.546 4.173   25.078 1.00 25.10  ? 5    PHE B O     1 ? 
ATOM   4178 C CB    . PHE B 1 26  ? -42.466 4.581   25.305 1.00 24.02  ? 5    PHE B CB    1 ? 
ATOM   4179 C CG    . PHE B 1 26  ? -41.030 4.137   25.475 1.00 28.39  ? 5    PHE B CG    1 ? 
ATOM   4180 C CD1   . PHE B 1 26  ? -40.232 4.677   26.479 1.00 29.96  ? 5    PHE B CD1   1 ? 
ATOM   4181 C CD2   . PHE B 1 26  ? -40.459 3.202   24.612 1.00 32.06  ? 5    PHE B CD2   1 ? 
ATOM   4182 C CE1   . PHE B 1 26  ? -38.914 4.276   26.636 1.00 28.04  ? 5    PHE B CE1   1 ? 
ATOM   4183 C CE2   . PHE B 1 26  ? -39.151 2.779   24.802 1.00 30.34  ? 5    PHE B CE2   1 ? 
ATOM   4184 C CZ    . PHE B 1 26  ? -38.383 3.313   25.810 1.00 29.09  ? 5    PHE B CZ    1 ? 
ATOM   4185 N N     . ILE B 1 27  ? -45.146 5.372   26.949 1.00 22.88  ? 6    ILE B N     1 ? 
ATOM   4186 C CA    . ILE B 1 27  ? -46.292 6.258   26.804 1.00 21.11  ? 6    ILE B CA    1 ? 
ATOM   4187 C C     . ILE B 1 27  ? -45.748 7.677   26.818 1.00 21.97  ? 6    ILE B C     1 ? 
ATOM   4188 O O     . ILE B 1 27  ? -45.038 8.045   27.757 1.00 22.20  ? 6    ILE B O     1 ? 
ATOM   4189 C CB    . ILE B 1 27  ? -47.335 6.048   27.910 1.00 21.43  ? 6    ILE B CB    1 ? 
ATOM   4190 C CG1   . ILE B 1 27  ? -47.976 4.663   27.846 1.00 21.93  ? 6    ILE B CG1   1 ? 
ATOM   4191 C CG2   . ILE B 1 27  ? -48.406 7.147   27.879 1.00 19.80  ? 6    ILE B CG2   1 ? 
ATOM   4192 C CD1   . ILE B 1 27  ? -48.917 4.364   29.000 1.00 23.96  ? 6    ILE B CD1   1 ? 
ATOM   4193 N N     . ILE B 1 28  ? -46.072 8.440   25.768 1.00 22.23  ? 7    ILE B N     1 ? 
ATOM   4194 C CA    . ILE B 1 28  ? -45.686 9.841   25.662 1.00 21.96  ? 7    ILE B CA    1 ? 
ATOM   4195 C C     . ILE B 1 28  ? -46.938 10.692  25.880 1.00 20.47  ? 7    ILE B C     1 ? 
ATOM   4196 O O     . ILE B 1 28  ? -47.941 10.509  25.209 1.00 20.61  ? 7    ILE B O     1 ? 
ATOM   4197 C CB    . ILE B 1 28  ? -45.014 10.151  24.318 1.00 22.03  ? 7    ILE B CB    1 ? 
ATOM   4198 C CG1   . ILE B 1 28  ? -43.739 9.294   24.114 1.00 24.93  ? 7    ILE B CG1   1 ? 
ATOM   4199 C CG2   . ILE B 1 28  ? -44.720 11.643  24.189 1.00 22.73  ? 7    ILE B CG2   1 ? 
ATOM   4200 C CD1   . ILE B 1 28  ? -43.281 9.176   22.674 1.00 22.00  ? 7    ILE B CD1   1 ? 
ATOM   4201 N N     . VAL B 1 29  ? -46.864 11.624  26.818 1.00 19.32  ? 8    VAL B N     1 ? 
ATOM   4202 C CA    . VAL B 1 29  ? -47.974 12.515  27.120 1.00 19.81  ? 8    VAL B CA    1 ? 
ATOM   4203 C C     . VAL B 1 29  ? -47.716 13.853  26.426 1.00 18.07  ? 8    VAL B C     1 ? 
ATOM   4204 O O     . VAL B 1 29  ? -46.849 14.612  26.857 1.00 17.86  ? 8    VAL B O     1 ? 
ATOM   4205 C CB    . VAL B 1 29  ? -48.118 12.705  28.641 1.00 19.99  ? 8    VAL B CB    1 ? 
ATOM   4206 C CG1   . VAL B 1 29  ? -49.215 13.727  28.993 1.00 19.90  ? 8    VAL B CG1   1 ? 
ATOM   4207 C CG2   . VAL B 1 29  ? -48.362 11.389  29.369 1.00 19.08  ? 8    VAL B CG2   1 ? 
ATOM   4208 N N     . GLY B 1 30  ? -48.538 14.148  25.410 1.00 20.00  ? 9    GLY B N     1 ? 
ATOM   4209 C CA    . GLY B 1 30  ? -48.542 15.417  24.693 1.00 19.15  ? 9    GLY B CA    1 ? 
ATOM   4210 C C     . GLY B 1 30  ? -47.927 15.260  23.296 1.00 20.54  ? 9    GLY B C     1 ? 
ATOM   4211 O O     . GLY B 1 30  ? -46.710 15.079  23.140 1.00 21.04  ? 9    GLY B O     1 ? 
ATOM   4212 N N     . ALA B 1 31  ? -48.775 15.379  22.272 1.00 20.40  ? 10   ALA B N     1 ? 
ATOM   4213 C CA    . ALA B 1 31  ? -48.317 15.344  20.888 1.00 21.40  ? 10   ALA B CA    1 ? 
ATOM   4214 C C     . ALA B 1 31  ? -48.146 16.770  20.386 1.00 19.95  ? 10   ALA B C     1 ? 
ATOM   4215 O O     . ALA B 1 31  ? -48.794 17.209  19.417 1.00 21.27  ? 10   ALA B O     1 ? 
ATOM   4216 C CB    . ALA B 1 31  ? -49.294 14.564  20.027 1.00 20.98  ? 10   ALA B CB    1 ? 
ATOM   4217 N N     . GLY B 1 32  ? -47.293 17.513  21.088 1.00 20.55  ? 11   GLY B N     1 ? 
ATOM   4218 C CA    . GLY B 1 32  ? -47.113 18.925  20.793 1.00 20.49  ? 11   GLY B CA    1 ? 
ATOM   4219 C C     . GLY B 1 32  ? -45.958 19.152  19.818 1.00 20.72  ? 11   GLY B C     1 ? 
ATOM   4220 O O     . GLY B 1 32  ? -46.063 18.859  18.629 1.00 19.62  ? 11   GLY B O     1 ? 
ATOM   4221 N N     . THR B 1 33  ? -44.881 19.748  20.329 1.00 19.50  ? 12   THR B N     1 ? 
ATOM   4222 C CA    . THR B 1 33  ? -43.714 20.031  19.524 1.00 20.07  ? 12   THR B CA    1 ? 
ATOM   4223 C C     . THR B 1 33  ? -42.680 18.915  19.705 1.00 19.26  ? 12   THR B C     1 ? 
ATOM   4224 O O     . THR B 1 33  ? -42.229 18.325  18.723 1.00 21.91  ? 12   THR B O     1 ? 
ATOM   4225 C CB    . THR B 1 33  ? -43.214 21.423  19.899 1.00 19.90  ? 12   THR B CB    1 ? 
ATOM   4226 O OG1   . THR B 1 33  ? -44.258 22.383  19.812 1.00 18.57  ? 12   THR B OG1   1 ? 
ATOM   4227 C CG2   . THR B 1 33  ? -42.121 21.900  18.980 1.00 20.58  ? 12   THR B CG2   1 ? 
ATOM   4228 N N     . ALA B 1 34  ? -42.252 18.656  20.946 1.00 19.12  ? 13   ALA B N     1 ? 
ATOM   4229 C CA    . ALA B 1 34  ? -41.282 17.618  21.221 1.00 20.14  ? 13   ALA B CA    1 ? 
ATOM   4230 C C     . ALA B 1 34  ? -41.880 16.205  21.144 1.00 22.96  ? 13   ALA B C     1 ? 
ATOM   4231 O O     . ALA B 1 34  ? -41.209 15.272  20.666 1.00 20.28  ? 13   ALA B O     1 ? 
ATOM   4232 C CB    . ALA B 1 34  ? -40.684 17.832  22.600 1.00 20.51  ? 13   ALA B CB    1 ? 
ATOM   4233 N N     . GLY B 1 35  ? -43.063 16.013  21.744 1.00 20.44  ? 14   GLY B N     1 ? 
ATOM   4234 C CA    . GLY B 1 35  ? -43.586 14.661  21.907 1.00 22.35  ? 14   GLY B CA    1 ? 
ATOM   4235 C C     . GLY B 1 35  ? -43.623 13.895  20.574 1.00 23.71  ? 14   GLY B C     1 ? 
ATOM   4236 O O     . GLY B 1 35  ? -43.255 12.717  20.505 1.00 22.23  ? 14   GLY B O     1 ? 
ATOM   4237 N N     . PRO B 1 36  ? -44.150 14.511  19.495 1.00 24.33  ? 15   PRO B N     1 ? 
ATOM   4238 C CA    . PRO B 1 36  ? -44.211 13.850  18.186 1.00 24.24  ? 15   PRO B CA    1 ? 
ATOM   4239 C C     . PRO B 1 36  ? -42.887 13.391  17.577 1.00 25.05  ? 15   PRO B C     1 ? 
ATOM   4240 O O     . PRO B 1 36  ? -42.839 12.349  16.920 1.00 26.22  ? 15   PRO B O     1 ? 
ATOM   4241 C CB    . PRO B 1 36  ? -44.939 14.887  17.323 1.00 25.13  ? 15   PRO B CB    1 ? 
ATOM   4242 C CG    . PRO B 1 36  ? -45.794 15.627  18.317 1.00 25.69  ? 15   PRO B CG    1 ? 
ATOM   4243 C CD    . PRO B 1 36  ? -44.856 15.808  19.500 1.00 25.25  ? 15   PRO B CD    1 ? 
ATOM   4244 N N     . VAL B 1 37  ? -41.815 14.139  17.852 1.00 25.13  ? 16   VAL B N     1 ? 
ATOM   4245 C CA    . VAL B 1 37  ? -40.478 13.789  17.433 1.00 26.22  ? 16   VAL B CA    1 ? 
ATOM   4246 C C     . VAL B 1 37  ? -40.093 12.456  18.071 1.00 27.84  ? 16   VAL B C     1 ? 
ATOM   4247 O O     . VAL B 1 37  ? -39.594 11.553  17.398 1.00 27.46  ? 16   VAL B O     1 ? 
ATOM   4248 C CB    . VAL B 1 37  ? -39.460 14.888  17.808 1.00 26.18  ? 16   VAL B CB    1 ? 
ATOM   4249 C CG1   . VAL B 1 37  ? -38.041 14.423  17.504 1.00 27.75  ? 16   VAL B CG1   1 ? 
ATOM   4250 C CG2   . VAL B 1 37  ? -39.786 16.206  17.120 1.00 24.78  ? 16   VAL B CG2   1 ? 
ATOM   4251 N N     . ILE B 1 38  ? -40.366 12.339  19.370 1.00 24.19  ? 17   ILE B N     1 ? 
ATOM   4252 C CA    . ILE B 1 38  ? -39.963 11.192  20.148 1.00 25.80  ? 17   ILE B CA    1 ? 
ATOM   4253 C C     . ILE B 1 38  ? -40.766 9.964   19.719 1.00 26.68  ? 17   ILE B C     1 ? 
ATOM   4254 O O     . ILE B 1 38  ? -40.205 8.868   19.619 1.00 26.94  ? 17   ILE B O     1 ? 
ATOM   4255 C CB    . ILE B 1 38  ? -40.107 11.475  21.655 1.00 25.97  ? 17   ILE B CB    1 ? 
ATOM   4256 C CG1   . ILE B 1 38  ? -39.249 12.685  22.060 1.00 27.91  ? 17   ILE B CG1   1 ? 
ATOM   4257 C CG2   . ILE B 1 38  ? -39.759 10.233  22.472 1.00 26.86  ? 17   ILE B CG2   1 ? 
ATOM   4258 C CD1   . ILE B 1 38  ? -39.477 13.151  23.477 1.00 26.29  ? 17   ILE B CD1   1 ? 
ATOM   4259 N N     . ALA B 1 39  ? -42.073 10.138  19.506 1.00 22.94  ? 18   ALA B N     1 ? 
ATOM   4260 C CA    . ALA B 1 39  ? -42.907 9.037   19.042 1.00 23.47  ? 18   ALA B CA    1 ? 
ATOM   4261 C C     . ALA B 1 39  ? -42.427 8.516   17.678 1.00 27.21  ? 18   ALA B C     1 ? 
ATOM   4262 O O     . ALA B 1 39  ? -42.456 7.313   17.431 1.00 27.11  ? 18   ALA B O     1 ? 
ATOM   4263 C CB    . ALA B 1 39  ? -44.357 9.463   18.985 1.00 21.96  ? 18   ALA B CB    1 ? 
ATOM   4264 N N     . SER B 1 40  ? -42.012 9.433   16.798 1.00 24.66  ? 19   SER B N     1 ? 
ATOM   4265 C CA    . SER B 1 40  ? -41.544 9.106   15.461 1.00 25.88  ? 19   SER B CA    1 ? 
ATOM   4266 C C     . SER B 1 40  ? -40.228 8.331   15.513 1.00 28.95  ? 19   SER B C     1 ? 
ATOM   4267 O O     . SER B 1 40  ? -40.095 7.309   14.843 1.00 31.94  ? 19   SER B O     1 ? 
ATOM   4268 C CB    . SER B 1 40  ? -41.407 10.358  14.641 1.00 26.76  ? 19   SER B CB    1 ? 
ATOM   4269 O OG    . SER B 1 40  ? -41.123 10.063  13.285 1.00 24.53  ? 19   SER B OG    1 ? 
ATOM   4270 N N     . ARG B 1 41  ? -39.283 8.807   16.337 1.00 31.24  ? 20   ARG B N     1 ? 
ATOM   4271 C CA    . ARG B 1 41  ? -37.950 8.239   16.432 1.00 30.61  ? 20   ARG B CA    1 ? 
ATOM   4272 C C     . ARG B 1 41  ? -37.994 6.895   17.144 1.00 29.42  ? 20   ARG B C     1 ? 
ATOM   4273 O O     . ARG B 1 41  ? -37.326 5.967   16.716 1.00 31.09  ? 20   ARG B O     1 ? 
ATOM   4274 C CB    . ARG B 1 41  ? -36.926 9.159   17.111 1.00 28.99  ? 20   ARG B CB    1 ? 
ATOM   4275 C CG    . ARG B 1 41  ? -36.542 10.423  16.348 1.00 28.92  ? 20   ARG B CG    1 ? 
ATOM   4276 C CD    . ARG B 1 41  ? -36.139 10.195  14.883 1.00 29.06  ? 20   ARG B CD    1 ? 
ATOM   4277 N NE    . ARG B 1 41  ? -35.577 11.401  14.272 1.00 27.14  ? 20   ARG B NE    1 ? 
ATOM   4278 C CZ    . ARG B 1 41  ? -35.340 11.551  12.981 1.00 29.88  ? 20   ARG B CZ    1 ? 
ATOM   4279 N NH1   . ARG B 1 41  ? -35.556 10.544  12.159 1.00 30.87  ? 20   ARG B NH1   1 ? 
ATOM   4280 N NH2   . ARG B 1 41  ? -34.891 12.699  12.507 1.00 31.12  ? 20   ARG B NH2   1 ? 
ATOM   4281 N N     . LEU B 1 42  ? -38.758 6.780   18.229 1.00 26.92  ? 21   LEU B N     1 ? 
ATOM   4282 C CA    . LEU B 1 42  ? -38.724 5.548   18.991 1.00 30.25  ? 21   LEU B CA    1 ? 
ATOM   4283 C C     . LEU B 1 42  ? -39.380 4.392   18.221 1.00 32.36  ? 21   LEU B C     1 ? 
ATOM   4284 O O     . LEU B 1 42  ? -39.123 3.236   18.559 1.00 30.85  ? 21   LEU B O     1 ? 
ATOM   4285 C CB    . LEU B 1 42  ? -39.380 5.692   20.357 1.00 28.30  ? 21   LEU B CB    1 ? 
ATOM   4286 C CG    . LEU B 1 42  ? -38.715 6.626   21.369 1.00 30.43  ? 21   LEU B CG    1 ? 
ATOM   4287 C CD1   . LEU B 1 42  ? -39.475 6.460   22.675 1.00 30.15  ? 21   LEU B CD1   1 ? 
ATOM   4288 C CD2   . LEU B 1 42  ? -37.258 6.334   21.563 1.00 32.17  ? 21   LEU B CD2   1 ? 
ATOM   4289 N N     . THR B 1 43  ? -40.303 4.677   17.288 1.00 32.09  ? 22   THR B N     1 ? 
ATOM   4290 C CA    . THR B 1 43  ? -41.022 3.600   16.608 1.00 30.88  ? 22   THR B CA    1 ? 
ATOM   4291 C C     . THR B 1 43  ? -40.287 3.198   15.328 1.00 35.22  ? 22   THR B C     1 ? 
ATOM   4292 O O     . THR B 1 43  ? -40.768 2.323   14.612 1.00 34.27  ? 22   THR B O     1 ? 
ATOM   4293 C CB    . THR B 1 43  ? -42.484 3.955   16.335 1.00 29.26  ? 22   THR B CB    1 ? 
ATOM   4294 O OG1   . THR B 1 43  ? -42.522 5.154   15.558 1.00 27.06  ? 22   THR B OG1   1 ? 
ATOM   4295 C CG2   . THR B 1 43  ? -43.283 4.082   17.624 1.00 29.81  ? 22   THR B CG2   1 ? 
ATOM   4296 N N     . GLU B 1 44  ? -39.118 3.806   15.071 1.00 34.64  ? 23   GLU B N     1 ? 
ATOM   4297 C CA    . GLU B 1 44  ? -38.234 3.332   14.014 1.00 39.42  ? 23   GLU B CA    1 ? 
ATOM   4298 C C     . GLU B 1 44  ? -37.761 1.904   14.290 1.00 40.52  ? 23   GLU B C     1 ? 
ATOM   4299 O O     . GLU B 1 44  ? -37.501 1.175   13.346 1.00 40.62  ? 23   GLU B O     1 ? 
ATOM   4300 C CB    . GLU B 1 44  ? -37.063 4.281   13.775 1.00 35.39  ? 23   GLU B CB    1 ? 
ATOM   4301 C CG    . GLU B 1 44  ? -37.513 5.590   13.130 1.00 36.01  ? 23   GLU B CG    1 ? 
ATOM   4302 C CD    . GLU B 1 44  ? -36.419 6.635   13.036 1.00 38.04  ? 23   GLU B CD    1 ? 
ATOM   4303 O OE1   . GLU B 1 44  ? -36.699 7.774   12.624 1.00 35.85  ? 23   GLU B OE1   1 ? 
ATOM   4304 O OE2   . GLU B 1 44  ? -35.278 6.285   13.402 1.00 38.47  ? 23   GLU B OE2   1 ? 
ATOM   4305 N N     . LYS B 1 45  ? -37.668 1.499   15.563 1.00 39.45  ? 24   LYS B N     1 ? 
ATOM   4306 C CA    . LYS B 1 45  ? -37.406 0.109   15.898 1.00 42.68  ? 24   LYS B CA    1 ? 
ATOM   4307 C C     . LYS B 1 45  ? -38.738 -0.626  16.025 1.00 45.74  ? 24   LYS B C     1 ? 
ATOM   4308 O O     . LYS B 1 45  ? -39.583 -0.245  16.840 1.00 39.48  ? 24   LYS B O     1 ? 
ATOM   4309 C CB    . LYS B 1 45  ? -36.637 -0.040  17.215 1.00 52.40  ? 24   LYS B CB    1 ? 
ATOM   4310 C CG    . LYS B 1 45  ? -35.441 0.883   17.419 1.00 59.15  ? 24   LYS B CG    1 ? 
ATOM   4311 C CD    . LYS B 1 45  ? -34.096 0.253   17.104 1.00 64.92  ? 24   LYS B CD    1 ? 
ATOM   4312 C CE    . LYS B 1 45  ? -32.960 1.082   17.611 1.00 68.72  ? 24   LYS B CE    1 ? 
ATOM   4313 N NZ    . LYS B 1 45  ? -31.682 0.368   17.580 1.00 71.11  ? 24   LYS B NZ    1 ? 
ATOM   4314 N N     . GLU B 1 46  ? -38.896 -1.702  15.242 1.00 40.78  ? 25   GLU B N     1 ? 
ATOM   4315 C CA    . GLU B 1 46  ? -40.181 -2.343  15.007 1.00 42.63  ? 25   GLU B CA    1 ? 
ATOM   4316 C C     . GLU B 1 46  ? -40.791 -2.929  16.276 1.00 40.68  ? 25   GLU B C     1 ? 
ATOM   4317 O O     . GLU B 1 46  ? -42.013 -2.983  16.399 1.00 43.97  ? 25   GLU B O     1 ? 
ATOM   4318 C CB    . GLU B 1 46  ? -40.053 -3.495  14.009 1.00 55.08  ? 25   GLU B CB    1 ? 
ATOM   4319 C CG    . GLU B 1 46  ? -40.398 -3.105  12.572 1.00 63.16  ? 25   GLU B CG    1 ? 
ATOM   4320 C CD    . GLU B 1 46  ? -40.448 -4.286  11.619 1.00 70.72  ? 25   GLU B CD    1 ? 
ATOM   4321 O OE1   . GLU B 1 46  ? -41.129 -4.189  10.566 1.00 75.23  ? 25   GLU B OE1   1 ? 
ATOM   4322 O OE2   . GLU B 1 46  ? -39.788 -5.299  11.948 1.00 69.35  ? 25   GLU B OE2   1 ? 
ATOM   4323 N N     . HIS B 1 47  ? -39.938 -3.370  17.199 1.00 44.70  ? 26   HIS B N     1 ? 
ATOM   4324 C CA    . HIS B 1 47  ? -40.353 -4.098  18.395 1.00 53.15  ? 26   HIS B CA    1 ? 
ATOM   4325 C C     . HIS B 1 47  ? -40.786 -3.147  19.523 1.00 49.88  ? 26   HIS B C     1 ? 
ATOM   4326 O O     . HIS B 1 47  ? -41.314 -3.599  20.544 1.00 51.05  ? 26   HIS B O     1 ? 
ATOM   4327 C CB    . HIS B 1 47  ? -39.229 -5.057  18.832 1.00 60.99  ? 26   HIS B CB    1 ? 
ATOM   4328 C CG    . HIS B 1 47  ? -37.874 -4.425  19.060 1.00 67.27  ? 26   HIS B CG    1 ? 
ATOM   4329 N ND1   . HIS B 1 47  ? -37.041 -3.994  18.042 1.00 69.75  ? 26   HIS B ND1   1 ? 
ATOM   4330 C CD2   . HIS B 1 47  ? -37.217 -4.144  20.201 1.00 65.03  ? 26   HIS B CD2   1 ? 
ATOM   4331 C CE1   . HIS B 1 47  ? -35.929 -3.482  18.557 1.00 65.88  ? 26   HIS B CE1   1 ? 
ATOM   4332 N NE2   . HIS B 1 47  ? -36.011 -3.569  19.865 1.00 62.56  ? 26   HIS B NE2   1 ? 
ATOM   4333 N N     . ILE B 1 48  ? -40.556 -1.833  19.350 1.00 42.47  ? 27   ILE B N     1 ? 
ATOM   4334 C CA    . ILE B 1 48  ? -40.814 -0.863  20.408 1.00 41.27  ? 27   ILE B CA    1 ? 
ATOM   4335 C C     . ILE B 1 48  ? -42.172 -0.216  20.157 1.00 35.27  ? 27   ILE B C     1 ? 
ATOM   4336 O O     . ILE B 1 48  ? -42.373 0.418   19.116 1.00 33.47  ? 27   ILE B O     1 ? 
ATOM   4337 C CB    . ILE B 1 48  ? -39.618 0.106   20.520 1.00 44.14  ? 27   ILE B CB    1 ? 
ATOM   4338 C CG1   . ILE B 1 48  ? -38.459 -0.662  21.168 1.00 48.92  ? 27   ILE B CG1   1 ? 
ATOM   4339 C CG2   . ILE B 1 48  ? -39.958 1.380   21.298 1.00 43.39  ? 27   ILE B CG2   1 ? 
ATOM   4340 C CD1   . ILE B 1 48  ? -37.157 0.093   21.245 1.00 58.43  ? 27   ILE B CD1   1 ? 
ATOM   4341 N N     . ASN B 1 49  ? -43.135 -0.534  21.039 1.00 32.42  ? 28   ASN B N     1 ? 
ATOM   4342 C CA    . ASN B 1 49  ? -44.504 -0.061  20.914 1.00 31.09  ? 28   ASN B CA    1 ? 
ATOM   4343 C C     . ASN B 1 49  ? -44.629 1.252   21.685 1.00 27.13  ? 28   ASN B C     1 ? 
ATOM   4344 O O     . ASN B 1 49  ? -44.331 1.287   22.868 1.00 23.39  ? 28   ASN B O     1 ? 
ATOM   4345 C CB    . ASN B 1 49  ? -45.543 -1.042  21.468 1.00 34.08  ? 28   ASN B CB    1 ? 
ATOM   4346 C CG    . ASN B 1 49  ? -45.608 -2.361  20.723 1.00 46.13  ? 28   ASN B CG    1 ? 
ATOM   4347 O OD1   . ASN B 1 49  ? -46.040 -3.376  21.281 1.00 53.08  ? 28   ASN B OD1   1 ? 
ATOM   4348 N ND2   . ASN B 1 49  ? -45.146 -2.397  19.485 1.00 45.06  ? 28   ASN B ND2   1 ? 
ATOM   4349 N N     . VAL B 1 50  ? -45.147 2.294   21.031 1.00 27.15  ? 29   VAL B N     1 ? 
ATOM   4350 C CA    . VAL B 1 50  ? -45.306 3.586   21.678 1.00 27.41  ? 29   VAL B CA    1 ? 
ATOM   4351 C C     . VAL B 1 50  ? -46.768 4.009   21.619 1.00 25.47  ? 29   VAL B C     1 ? 
ATOM   4352 O O     . VAL B 1 50  ? -47.399 3.921   20.574 1.00 27.39  ? 29   VAL B O     1 ? 
ATOM   4353 C CB    . VAL B 1 50  ? -44.380 4.611   21.010 1.00 27.18  ? 29   VAL B CB    1 ? 
ATOM   4354 C CG1   . VAL B 1 50  ? -44.699 6.040   21.442 1.00 26.46  ? 29   VAL B CG1   1 ? 
ATOM   4355 C CG2   . VAL B 1 50  ? -42.926 4.273   21.263 1.00 29.94  ? 29   VAL B CG2   1 ? 
ATOM   4356 N N     . LEU B 1 51  ? -47.293 4.440   22.771 1.00 26.99  ? 30   LEU B N     1 ? 
ATOM   4357 C CA    . LEU B 1 51  ? -48.559 5.152   22.848 1.00 26.50  ? 30   LEU B CA    1 ? 
ATOM   4358 C C     . LEU B 1 51  ? -48.301 6.649   23.007 1.00 25.46  ? 30   LEU B C     1 ? 
ATOM   4359 O O     . LEU B 1 51  ? -47.578 7.034   23.928 1.00 24.68  ? 30   LEU B O     1 ? 
ATOM   4360 C CB    . LEU B 1 51  ? -49.354 4.604   24.028 1.00 27.55  ? 30   LEU B CB    1 ? 
ATOM   4361 C CG    . LEU B 1 51  ? -50.689 5.299   24.325 1.00 26.84  ? 30   LEU B CG    1 ? 
ATOM   4362 C CD1   . LEU B 1 51  ? -51.618 5.090   23.129 1.00 26.60  ? 30   LEU B CD1   1 ? 
ATOM   4363 C CD2   . LEU B 1 51  ? -51.285 4.738   25.594 1.00 27.15  ? 30   LEU B CD2   1 ? 
ATOM   4364 N N     . LEU B 1 52  ? -48.892 7.452   22.107 1.00 20.95  ? 31   LEU B N     1 ? 
ATOM   4365 C CA    . LEU B 1 52  ? -48.823 8.912   22.142 1.00 21.30  ? 31   LEU B CA    1 ? 
ATOM   4366 C C     . LEU B 1 52  ? -50.213 9.463   22.450 1.00 21.83  ? 31   LEU B C     1 ? 
ATOM   4367 O O     . LEU B 1 52  ? -51.160 9.201   21.701 1.00 25.00  ? 31   LEU B O     1 ? 
ATOM   4368 C CB    . LEU B 1 52  ? -48.286 9.454   20.817 1.00 21.65  ? 31   LEU B CB    1 ? 
ATOM   4369 C CG    . LEU B 1 52  ? -48.293 10.982  20.657 1.00 22.81  ? 31   LEU B CG    1 ? 
ATOM   4370 C CD1   . LEU B 1 52  ? -47.331 11.635  21.679 1.00 21.48  ? 31   LEU B CD1   1 ? 
ATOM   4371 C CD2   . LEU B 1 52  ? -47.943 11.369  19.265 1.00 22.62  ? 31   LEU B CD2   1 ? 
ATOM   4372 N N     . LEU B 1 53  ? -50.345 10.159  23.588 1.00 20.17  ? 32   LEU B N     1 ? 
ATOM   4373 C CA    . LEU B 1 53  ? -51.611 10.718  24.027 1.00 21.01  ? 32   LEU B CA    1 ? 
ATOM   4374 C C     . LEU B 1 53  ? -51.631 12.231  23.827 1.00 21.85  ? 32   LEU B C     1 ? 
ATOM   4375 O O     . LEU B 1 53  ? -50.647 12.909  24.148 1.00 22.79  ? 32   LEU B O     1 ? 
ATOM   4376 C CB    . LEU B 1 53  ? -51.839 10.371  25.495 1.00 20.65  ? 32   LEU B CB    1 ? 
ATOM   4377 C CG    . LEU B 1 53  ? -51.797 8.875   25.821 1.00 22.01  ? 32   LEU B CG    1 ? 
ATOM   4378 C CD1   . LEU B 1 53  ? -51.845 8.614   27.307 1.00 21.73  ? 32   LEU B CD1   1 ? 
ATOM   4379 C CD2   . LEU B 1 53  ? -52.921 8.168   25.113 1.00 21.50  ? 32   LEU B CD2   1 ? 
ATOM   4380 N N     . GLU B 1 54  ? -52.791 12.737  23.387 1.00 18.61  ? 33   GLU B N     1 ? 
ATOM   4381 C CA    . GLU B 1 54  ? -52.998 14.153  23.120 1.00 18.71  ? 33   GLU B CA    1 ? 
ATOM   4382 C C     . GLU B 1 54  ? -54.390 14.574  23.582 1.00 18.75  ? 33   GLU B C     1 ? 
ATOM   4383 O O     . GLU B 1 54  ? -55.401 13.957  23.205 1.00 19.54  ? 33   GLU B O     1 ? 
ATOM   4384 C CB    . GLU B 1 54  ? -52.721 14.492  21.654 1.00 18.19  ? 33   GLU B CB    1 ? 
ATOM   4385 C CG    . GLU B 1 54  ? -53.140 15.912  21.260 1.00 20.25  ? 33   GLU B CG    1 ? 
ATOM   4386 C CD    . GLU B 1 54  ? -52.477 16.995  22.108 1.00 19.42  ? 33   GLU B CD    1 ? 
ATOM   4387 O OE1   . GLU B 1 54  ? -53.142 17.961  22.549 1.00 19.32  ? 33   GLU B OE1   1 ? 
ATOM   4388 O OE2   . GLU B 1 54  ? -51.261 16.862  22.335 1.00 19.27  ? 33   GLU B OE2   1 ? 
ATOM   4389 N N     . ALA B 1 55  ? -54.468 15.675  24.358 1.00 17.76  ? 34   ALA B N     1 ? 
ATOM   4390 C CA    . ALA B 1 55  ? -55.741 16.188  24.845 1.00 18.99  ? 34   ALA B CA    1 ? 
ATOM   4391 C C     . ALA B 1 55  ? -56.601 16.760  23.716 1.00 21.77  ? 34   ALA B C     1 ? 
ATOM   4392 O O     . ALA B 1 55  ? -57.827 16.651  23.762 1.00 21.05  ? 34   ALA B O     1 ? 
ATOM   4393 C CB    . ALA B 1 55  ? -55.490 17.228  25.898 1.00 20.13  ? 34   ALA B CB    1 ? 
ATOM   4394 N N     . GLY B 1 56  ? -55.959 17.428  22.744 1.00 19.62  ? 35   GLY B N     1 ? 
ATOM   4395 C CA    . GLY B 1 56  ? -56.673 18.023  21.624 1.00 21.75  ? 35   GLY B CA    1 ? 
ATOM   4396 C C     . GLY B 1 56  ? -56.920 16.986  20.517 1.00 18.99  ? 35   GLY B C     1 ? 
ATOM   4397 O O     . GLY B 1 56  ? -56.677 15.794  20.705 1.00 18.62  ? 35   GLY B O     1 ? 
ATOM   4398 N N     . GLY B 1 57  ? -57.467 17.456  19.396 1.00 20.36  ? 36   GLY B N     1 ? 
ATOM   4399 C CA    . GLY B 1 57  ? -57.711 16.638  18.225 1.00 22.25  ? 36   GLY B CA    1 ? 
ATOM   4400 C C     . GLY B 1 57  ? -56.548 16.768  17.236 1.00 22.87  ? 36   GLY B C     1 ? 
ATOM   4401 O O     . GLY B 1 57  ? -55.520 17.390  17.522 1.00 21.83  ? 36   GLY B O     1 ? 
ATOM   4402 N N     . GLU B 1 58  ? -56.746 16.184  16.060 1.00 23.94  ? 37   GLU B N     1 ? 
ATOM   4403 C CA    . GLU B 1 58  ? -55.840 16.308  14.939 1.00 22.34  ? 37   GLU B CA    1 ? 
ATOM   4404 C C     . GLU B 1 58  ? -55.898 17.743  14.447 1.00 21.77  ? 37   GLU B C     1 ? 
ATOM   4405 O O     . GLU B 1 58  ? -56.841 18.476  14.730 1.00 21.35  ? 37   GLU B O     1 ? 
ATOM   4406 C CB    . GLU B 1 58  ? -56.211 15.313  13.835 1.00 25.50  ? 37   GLU B CB    1 ? 
ATOM   4407 C CG    . GLU B 1 58  ? -55.982 13.855  14.212 1.00 27.26  ? 37   GLU B CG    1 ? 
ATOM   4408 C CD    . GLU B 1 58  ? -54.537 13.429  14.448 1.00 24.98  ? 37   GLU B CD    1 ? 
ATOM   4409 O OE1   . GLU B 1 58  ? -54.335 12.339  14.994 1.00 26.89  ? 37   GLU B OE1   1 ? 
ATOM   4410 O OE2   . GLU B 1 58  ? -53.590 14.163  14.119 1.00 25.97  ? 37   GLU B OE2   1 ? 
ATOM   4411 N N     . ASN B 1 59  ? -54.835 18.153  13.760 1.00 22.72  ? 38   ASN B N     1 ? 
ATOM   4412 C CA    . ASN B 1 59  ? -54.732 19.499  13.220 1.00 23.85  ? 38   ASN B CA    1 ? 
ATOM   4413 C C     . ASN B 1 59  ? -55.491 19.578  11.889 1.00 25.91  ? 38   ASN B C     1 ? 
ATOM   4414 O O     . ASN B 1 59  ? -54.872 19.512  10.816 1.00 24.53  ? 38   ASN B O     1 ? 
ATOM   4415 C CB    . ASN B 1 59  ? -53.259 19.870  13.088 1.00 20.40  ? 38   ASN B CB    1 ? 
ATOM   4416 C CG    . ASN B 1 59  ? -53.035 21.324  12.756 1.00 21.53  ? 38   ASN B CG    1 ? 
ATOM   4417 O OD1   . ASN B 1 59  ? -53.984 22.108  12.643 1.00 22.66  ? 38   ASN B OD1   1 ? 
ATOM   4418 N ND2   . ASN B 1 59  ? -51.773 21.694  12.619 1.00 22.14  ? 38   ASN B ND2   1 ? 
ATOM   4419 N N     . THR B 1 60  ? -56.795 19.836  11.988 1.00 25.49  ? 39   THR B N     1 ? 
ATOM   4420 C CA    . THR B 1 60  ? -57.700 19.837  10.839 1.00 28.34  ? 39   THR B CA    1 ? 
ATOM   4421 C C     . THR B 1 60  ? -58.322 21.204  10.582 1.00 27.80  ? 39   THR B C     1 ? 
ATOM   4422 O O     . THR B 1 60  ? -59.009 21.363  9.571  1.00 26.78  ? 39   THR B O     1 ? 
ATOM   4423 C CB    . THR B 1 60  ? -58.794 18.782  11.012 1.00 27.16  ? 39   THR B CB    1 ? 
ATOM   4424 O OG1   . THR B 1 60  ? -59.528 19.110  12.182 1.00 29.50  ? 39   THR B OG1   1 ? 
ATOM   4425 C CG2   . THR B 1 60  ? -58.242 17.371  11.131 1.00 32.44  ? 39   THR B CG2   1 ? 
ATOM   4426 N N     . ASN B 1 61  ? -58.090 22.203  11.456 1.00 26.61  ? 40   ASN B N     1 ? 
ATOM   4427 C CA    . ASN B 1 61  ? -58.640 23.530  11.237 1.00 25.37  ? 40   ASN B CA    1 ? 
ATOM   4428 C C     . ASN B 1 61  ? -57.692 24.331  10.349 1.00 28.12  ? 40   ASN B C     1 ? 
ATOM   4429 O O     . ASN B 1 61  ? -56.674 24.834  10.816 1.00 24.83  ? 40   ASN B O     1 ? 
ATOM   4430 C CB    . ASN B 1 61  ? -58.884 24.281  12.539 1.00 27.74  ? 40   ASN B CB    1 ? 
ATOM   4431 C CG    . ASN B 1 61  ? -59.516 25.643  12.354 1.00 32.20  ? 40   ASN B CG    1 ? 
ATOM   4432 O OD1   . ASN B 1 61  ? -59.513 26.198  11.251 1.00 32.20  ? 40   ASN B OD1   1 ? 
ATOM   4433 N ND2   . ASN B 1 61  ? -60.062 26.221  13.423 1.00 30.54  ? 40   ASN B ND2   1 ? 
ATOM   4434 N N     . GLU B 1 62  ? -58.021 24.460  9.056  1.00 29.24  ? 41   GLU B N     1 ? 
ATOM   4435 C CA    . GLU B 1 62  ? -57.072 24.999  8.096  1.00 31.23  ? 41   GLU B CA    1 ? 
ATOM   4436 C C     . GLU B 1 62  ? -56.750 26.466  8.395  1.00 25.48  ? 41   GLU B C     1 ? 
ATOM   4437 O O     . GLU B 1 62  ? -55.719 26.951  7.960  1.00 25.72  ? 41   GLU B O     1 ? 
ATOM   4438 C CB    . GLU B 1 62  ? -57.551 24.872  6.646  1.00 41.34  ? 41   GLU B CB    1 ? 
ATOM   4439 C CG    . GLU B 1 62  ? -57.115 23.579  5.960  1.00 49.29  ? 41   GLU B CG    1 ? 
ATOM   4440 C CD    . GLU B 1 62  ? -57.405 23.619  4.467  1.00 56.49  ? 41   GLU B CD    1 ? 
ATOM   4441 O OE1   . GLU B 1 62  ? -58.233 22.797  4.025  1.00 57.90  ? 41   GLU B OE1   1 ? 
ATOM   4442 O OE2   . GLU B 1 62  ? -56.804 24.455  3.743  1.00 59.45  ? 41   GLU B OE2   1 ? 
ATOM   4443 N N     . LEU B 1 63  ? -57.625 27.182  9.102  1.00 23.88  ? 42   LEU B N     1 ? 
ATOM   4444 C CA    . LEU B 1 63  ? -57.386 28.577  9.430  1.00 24.61  ? 42   LEU B CA    1 ? 
ATOM   4445 C C     . LEU B 1 63  ? -56.102 28.704  10.252 1.00 26.18  ? 42   LEU B C     1 ? 
ATOM   4446 O O     . LEU B 1 63  ? -55.334 29.644  10.106 1.00 27.40  ? 42   LEU B O     1 ? 
ATOM   4447 C CB    . LEU B 1 63  ? -58.602 29.137  10.162 1.00 23.49  ? 42   LEU B CB    1 ? 
ATOM   4448 C CG    . LEU B 1 63  ? -58.487 30.566  10.708 1.00 26.61  ? 42   LEU B CG    1 ? 
ATOM   4449 C CD1   . LEU B 1 63  ? -58.165 31.607  9.648  1.00 32.13  ? 42   LEU B CD1   1 ? 
ATOM   4450 C CD2   . LEU B 1 63  ? -59.777 30.971  11.386 1.00 29.29  ? 42   LEU B CD2   1 ? 
ATOM   4451 N N     . SER B 1 64  ? -55.822 27.686  11.066 1.00 24.98  ? 43   SER B N     1 ? 
ATOM   4452 C CA    . SER B 1 64  ? -54.626 27.671  11.896 1.00 25.11  ? 43   SER B CA    1 ? 
ATOM   4453 C C     . SER B 1 64  ? -53.344 27.589  11.066 1.00 25.92  ? 43   SER B C     1 ? 
ATOM   4454 O O     . SER B 1 64  ? -52.260 27.830  11.601 1.00 25.19  ? 43   SER B O     1 ? 
ATOM   4455 C CB    . SER B 1 64  ? -54.695 26.530  12.840 1.00 23.10  ? 43   SER B CB    1 ? 
ATOM   4456 O OG    . SER B 1 64  ? -54.377 25.321  12.173 1.00 22.58  ? 43   SER B OG    1 ? 
ATOM   4457 N N     . ARG B 1 65  ? -53.456 27.230  9.779  1.00 22.49  ? 44   ARG B N     1 ? 
ATOM   4458 C CA    . ARG B 1 65  ? -52.277 27.026  8.939  1.00 24.39  ? 44   ARG B CA    1 ? 
ATOM   4459 C C     . ARG B 1 65  ? -51.972 28.240  8.058  1.00 22.88  ? 44   ARG B C     1 ? 
ATOM   4460 O O     . ARG B 1 65  ? -51.039 28.204  7.251  1.00 22.93  ? 44   ARG B O     1 ? 
ATOM   4461 C CB    . ARG B 1 65  ? -52.456 25.767  8.084  1.00 25.17  ? 44   ARG B CB    1 ? 
ATOM   4462 C CG    . ARG B 1 65  ? -52.600 24.480  8.887  1.00 27.60  ? 44   ARG B CG    1 ? 
ATOM   4463 C CD    . ARG B 1 65  ? -52.662 23.331  7.890  1.00 28.09  ? 44   ARG B CD    1 ? 
ATOM   4464 N NE    . ARG B 1 65  ? -52.819 22.021  8.525  1.00 26.32  ? 44   ARG B NE    1 ? 
ATOM   4465 C CZ    . ARG B 1 65  ? -51.819 21.316  9.011  1.00 23.80  ? 44   ARG B CZ    1 ? 
ATOM   4466 N NH1   . ARG B 1 65  ? -50.583 21.747  8.956  1.00 26.35  ? 44   ARG B NH1   1 ? 
ATOM   4467 N NH2   . ARG B 1 65  ? -52.053 20.164  9.586  1.00 27.73  ? 44   ARG B NH2   1 ? 
ATOM   4468 N N     . ILE B 1 66  ? -52.772 29.303  8.161  1.00 24.00  ? 45   ILE B N     1 ? 
ATOM   4469 C CA    . ILE B 1 66  ? -52.603 30.453  7.288  1.00 24.73  ? 45   ILE B CA    1 ? 
ATOM   4470 C C     . ILE B 1 66  ? -51.616 31.430  7.924  1.00 25.99  ? 45   ILE B C     1 ? 
ATOM   4471 O O     . ILE B 1 66  ? -51.863 31.919  9.019  1.00 25.97  ? 45   ILE B O     1 ? 
ATOM   4472 C CB    . ILE B 1 66  ? -53.961 31.116  7.005  1.00 27.52  ? 45   ILE B CB    1 ? 
ATOM   4473 C CG1   . ILE B 1 66  ? -54.984 30.120  6.476  1.00 26.45  ? 45   ILE B CG1   1 ? 
ATOM   4474 C CG2   . ILE B 1 66  ? -53.808 32.309  6.072  1.00 28.11  ? 45   ILE B CG2   1 ? 
ATOM   4475 C CD1   . ILE B 1 66  ? -56.341 30.749  6.232  1.00 26.48  ? 45   ILE B CD1   1 ? 
ATOM   4476 N N     . PRO B 1 67  ? -50.484 31.760  7.265  1.00 25.58  ? 46   PRO B N     1 ? 
ATOM   4477 C CA    . PRO B 1 67  ? -49.437 32.561  7.890  1.00 24.24  ? 46   PRO B CA    1 ? 
ATOM   4478 C C     . PRO B 1 67  ? -49.862 33.918  8.425  1.00 25.52  ? 46   PRO B C     1 ? 
ATOM   4479 O O     . PRO B 1 67  ? -49.349 34.364  9.450  1.00 28.40  ? 46   PRO B O     1 ? 
ATOM   4480 C CB    . PRO B 1 67  ? -48.334 32.696  6.828  1.00 27.47  ? 46   PRO B CB    1 ? 
ATOM   4481 C CG    . PRO B 1 67  ? -48.927 32.173  5.547  1.00 27.30  ? 46   PRO B CG    1 ? 
ATOM   4482 C CD    . PRO B 1 67  ? -50.114 31.306  5.913  1.00 27.72  ? 46   PRO B CD    1 ? 
ATOM   4483 N N     . GLY B 1 68  ? -50.761 34.582  7.691  1.00 23.31  ? 47   GLY B N     1 ? 
ATOM   4484 C CA    . GLY B 1 68  ? -51.209 35.906  8.052  1.00 23.23  ? 47   GLY B CA    1 ? 
ATOM   4485 C C     . GLY B 1 68  ? -52.500 35.939  8.854  1.00 22.09  ? 47   GLY B C     1 ? 
ATOM   4486 O O     . GLY B 1 68  ? -52.936 37.048  9.176  1.00 25.31  ? 47   GLY B O     1 ? 
ATOM   4487 N N     . ALA B 1 69  ? -53.164 34.781  9.069  1.00 22.47  ? 48   ALA B N     1 ? 
ATOM   4488 C CA    . ALA B 1 69  ? -54.456 34.778  9.749  1.00 25.67  ? 48   ALA B CA    1 ? 
ATOM   4489 C C     . ALA B 1 69  ? -54.574 33.738  10.875 1.00 25.52  ? 48   ALA B C     1 ? 
ATOM   4490 O O     . ALA B 1 69  ? -55.638 33.625  11.486 1.00 23.34  ? 48   ALA B O     1 ? 
ATOM   4491 C CB    . ALA B 1 69  ? -55.568 34.564  8.733  1.00 25.54  ? 48   ALA B CB    1 ? 
ATOM   4492 N N     . PHE B 1 70  ? -53.529 32.930  11.106 1.00 22.06  ? 49   PHE B N     1 ? 
ATOM   4493 C CA    . PHE B 1 70  ? -53.615 31.806  12.031 1.00 23.35  ? 49   PHE B CA    1 ? 
ATOM   4494 C C     . PHE B 1 70  ? -54.126 32.269  13.407 1.00 23.09  ? 49   PHE B C     1 ? 
ATOM   4495 O O     . PHE B 1 70  ? -54.774 31.491  14.131 1.00 22.67  ? 49   PHE B O     1 ? 
ATOM   4496 C CB    . PHE B 1 70  ? -52.241 31.121  12.187 1.00 21.00  ? 49   PHE B CB    1 ? 
ATOM   4497 C CG    . PHE B 1 70  ? -51.265 31.998  12.954 1.00 23.46  ? 49   PHE B CG    1 ? 
ATOM   4498 C CD1   . PHE B 1 70  ? -50.518 32.979  12.300 1.00 22.92  ? 49   PHE B CD1   1 ? 
ATOM   4499 C CD2   . PHE B 1 70  ? -51.154 31.899  14.341 1.00 21.58  ? 49   PHE B CD2   1 ? 
ATOM   4500 C CE1   . PHE B 1 70  ? -49.715 33.853  13.009 1.00 21.59  ? 49   PHE B CE1   1 ? 
ATOM   4501 C CE2   . PHE B 1 70  ? -50.345 32.778  15.042 1.00 22.63  ? 49   PHE B CE2   1 ? 
ATOM   4502 C CZ    . PHE B 1 70  ? -49.634 33.752  14.379 1.00 21.73  ? 49   PHE B CZ    1 ? 
ATOM   4503 N N     . PHE B 1 71  ? -53.746 33.490  13.823 1.00 22.27  ? 50   PHE B N     1 ? 
ATOM   4504 C CA    . PHE B 1 71  ? -53.980 33.943  15.194 1.00 25.39  ? 50   PHE B CA    1 ? 
ATOM   4505 C C     . PHE B 1 71  ? -55.474 34.075  15.486 1.00 26.69  ? 50   PHE B C     1 ? 
ATOM   4506 O O     . PHE B 1 71  ? -55.871 34.186  16.647 1.00 25.69  ? 50   PHE B O     1 ? 
ATOM   4507 C CB    . PHE B 1 71  ? -53.245 35.252  15.524 1.00 26.63  ? 50   PHE B CB    1 ? 
ATOM   4508 C CG    . PHE B 1 71  ? -53.435 36.345  14.489 1.00 27.87  ? 50   PHE B CG    1 ? 
ATOM   4509 C CD1   . PHE B 1 71  ? -54.506 37.225  14.574 1.00 31.63  ? 50   PHE B CD1   1 ? 
ATOM   4510 C CD2   . PHE B 1 71  ? -52.542 36.483  13.436 1.00 26.36  ? 50   PHE B CD2   1 ? 
ATOM   4511 C CE1   . PHE B 1 71  ? -54.677 38.215  13.608 1.00 33.44  ? 50   PHE B CE1   1 ? 
ATOM   4512 C CE2   . PHE B 1 71  ? -52.717 37.469  12.474 1.00 30.19  ? 50   PHE B CE2   1 ? 
ATOM   4513 C CZ    . PHE B 1 71  ? -53.779 38.324  12.551 1.00 29.55  ? 50   PHE B CZ    1 ? 
ATOM   4514 N N     . LYS B 1 72  ? -56.315 33.988  14.456 1.00 25.65  ? 51   LYS B N     1 ? 
ATOM   4515 C CA    . LYS B 1 72  ? -57.754 33.933  14.662 1.00 26.42  ? 51   LYS B CA    1 ? 
ATOM   4516 C C     . LYS B 1 72  ? -58.188 32.644  15.366 1.00 24.97  ? 51   LYS B C     1 ? 
ATOM   4517 O O     . LYS B 1 72  ? -59.309 32.580  15.849 1.00 23.62  ? 51   LYS B O     1 ? 
ATOM   4518 C CB    . LYS B 1 72  ? -58.512 34.083  13.341 1.00 33.76  ? 51   LYS B CB    1 ? 
ATOM   4519 C CG    . LYS B 1 72  ? -58.630 35.513  12.831 1.00 40.06  ? 51   LYS B CG    1 ? 
ATOM   4520 C CD    . LYS B 1 72  ? -59.503 35.533  11.579 1.00 54.20  ? 51   LYS B CD    1 ? 
ATOM   4521 C CE    . LYS B 1 72  ? -60.615 36.564  11.598 1.00 61.68  ? 51   LYS B CE    1 ? 
ATOM   4522 N NZ    . LYS B 1 72  ? -61.752 36.142  10.778 1.00 60.61  ? 51   LYS B NZ    1 ? 
ATOM   4523 N N     . VAL B 1 73  ? -57.329 31.626  15.486 1.00 21.47  ? 52   VAL B N     1 ? 
ATOM   4524 C CA    . VAL B 1 73  ? -57.728 30.440  16.230 1.00 23.47  ? 52   VAL B CA    1 ? 
ATOM   4525 C C     . VAL B 1 73  ? -57.343 30.547  17.709 1.00 22.46  ? 52   VAL B C     1 ? 
ATOM   4526 O O     . VAL B 1 73  ? -57.689 29.672  18.501 1.00 23.18  ? 52   VAL B O     1 ? 
ATOM   4527 C CB    . VAL B 1 73  ? -57.204 29.129  15.629 1.00 23.53  ? 52   VAL B CB    1 ? 
ATOM   4528 C CG1   . VAL B 1 73  ? -57.509 29.026  14.151 1.00 25.26  ? 52   VAL B CG1   1 ? 
ATOM   4529 C CG2   . VAL B 1 73  ? -55.720 28.878  15.934 1.00 25.19  ? 52   VAL B CG2   1 ? 
ATOM   4530 N N     . LEU B 1 74  ? -56.618 31.598  18.093 1.00 22.45  ? 53   LEU B N     1 ? 
ATOM   4531 C CA    . LEU B 1 74  ? -56.364 31.825  19.509 1.00 24.40  ? 53   LEU B CA    1 ? 
ATOM   4532 C C     . LEU B 1 74  ? -57.705 32.031  20.199 1.00 23.51  ? 53   LEU B C     1 ? 
ATOM   4533 O O     . LEU B 1 74  ? -58.620 32.654  19.666 1.00 24.33  ? 53   LEU B O     1 ? 
ATOM   4534 C CB    . LEU B 1 74  ? -55.422 33.017  19.739 1.00 23.08  ? 53   LEU B CB    1 ? 
ATOM   4535 C CG    . LEU B 1 74  ? -53.998 32.870  19.202 1.00 24.96  ? 53   LEU B CG    1 ? 
ATOM   4536 C CD1   . LEU B 1 74  ? -53.165 34.132  19.462 1.00 26.30  ? 53   LEU B CD1   1 ? 
ATOM   4537 C CD2   . LEU B 1 74  ? -53.283 31.655  19.809 1.00 27.87  ? 53   LEU B CD2   1 ? 
ATOM   4538 N N     . GLY B 1 75  ? -57.836 31.457  21.383 1.00 23.23  ? 54   GLY B N     1 ? 
ATOM   4539 C CA    . GLY B 1 75  ? -59.062 31.583  22.146 1.00 23.92  ? 54   GLY B CA    1 ? 
ATOM   4540 C C     . GLY B 1 75  ? -60.095 30.529  21.765 1.00 21.85  ? 54   GLY B C     1 ? 
ATOM   4541 O O     . GLY B 1 75  ? -61.114 30.453  22.422 1.00 25.72  ? 54   GLY B O     1 ? 
ATOM   4542 N N     . THR B 1 76  ? -59.799 29.668  20.796 1.00 22.41  ? 55   THR B N     1 ? 
ATOM   4543 C CA    . THR B 1 76  ? -60.723 28.616  20.384 1.00 22.85  ? 55   THR B CA    1 ? 
ATOM   4544 C C     . THR B 1 76  ? -60.300 27.306  21.040 1.00 22.98  ? 55   THR B C     1 ? 
ATOM   4545 O O     . THR B 1 76  ? -59.420 27.308  21.896 1.00 20.49  ? 55   THR B O     1 ? 
ATOM   4546 C CB    . THR B 1 76  ? -60.741 28.448  18.857 1.00 24.24  ? 55   THR B CB    1 ? 
ATOM   4547 O OG1   . THR B 1 76  ? -59.504 27.838  18.479 1.00 21.16  ? 55   THR B OG1   1 ? 
ATOM   4548 C CG2   . THR B 1 76  ? -60.988 29.753  18.125 1.00 23.96  ? 55   THR B CG2   1 ? 
ATOM   4549 N N     . ASP B 1 77  ? -60.864 26.184  20.564 1.00 22.93  ? 56   ASP B N     1 ? 
ATOM   4550 C CA    . ASP B 1 77  ? -60.581 24.866  21.124 1.00 23.64  ? 56   ASP B CA    1 ? 
ATOM   4551 C C     . ASP B 1 77  ? -59.160 24.411  20.808 1.00 21.78  ? 56   ASP B C     1 ? 
ATOM   4552 O O     . ASP B 1 77  ? -58.707 23.403  21.325 1.00 20.12  ? 56   ASP B O     1 ? 
ATOM   4553 C CB    . ASP B 1 77  ? -61.565 23.819  20.622 1.00 29.82  ? 56   ASP B CB    1 ? 
ATOM   4554 C CG    . ASP B 1 77  ? -62.944 23.942  21.250 1.00 41.46  ? 56   ASP B CG    1 ? 
ATOM   4555 O OD1   . ASP B 1 77  ? -63.018 24.068  22.514 1.00 39.88  ? 56   ASP B OD1   1 ? 
ATOM   4556 O OD2   . ASP B 1 77  ? -63.928 23.942  20.473 1.00 54.54  ? 56   ASP B OD2   1 ? 
ATOM   4557 N N     . TYR B 1 78  ? -58.462 25.126  19.907 1.00 20.84  ? 57   TYR B N     1 ? 
ATOM   4558 C CA    . TYR B 1 78  ? -57.049 24.898  19.652 1.00 19.14  ? 57   TYR B CA    1 ? 
ATOM   4559 C C     . TYR B 1 78  ? -56.124 25.435  20.758 1.00 18.89  ? 57   TYR B C     1 ? 
ATOM   4560 O O     . TYR B 1 78  ? -54.908 25.290  20.627 1.00 16.79  ? 57   TYR B O     1 ? 
ATOM   4561 C CB    . TYR B 1 78  ? -56.639 25.620  18.360 1.00 20.21  ? 57   TYR B CB    1 ? 
ATOM   4562 C CG    . TYR B 1 78  ? -56.594 24.723  17.133 1.00 20.17  ? 57   TYR B CG    1 ? 
ATOM   4563 C CD1   . TYR B 1 78  ? -57.588 23.783  16.866 1.00 21.82  ? 57   TYR B CD1   1 ? 
ATOM   4564 C CD2   . TYR B 1 78  ? -55.525 24.804  16.259 1.00 21.58  ? 57   TYR B CD2   1 ? 
ATOM   4565 C CE1   . TYR B 1 78  ? -57.532 22.981  15.732 1.00 22.80  ? 57   TYR B CE1   1 ? 
ATOM   4566 C CE2   . TYR B 1 78  ? -55.447 23.998  15.138 1.00 22.52  ? 57   TYR B CE2   1 ? 
ATOM   4567 C CZ    . TYR B 1 78  ? -56.465 23.107  14.858 1.00 23.32  ? 57   TYR B CZ    1 ? 
ATOM   4568 O OH    . TYR B 1 78  ? -56.322 22.341  13.736 1.00 22.26  ? 57   TYR B OH    1 ? 
ATOM   4569 N N     . ASP B 1 79  ? -56.681 26.008  21.845 1.00 20.50  ? 58   ASP B N     1 ? 
ATOM   4570 C CA    . ASP B 1 79  ? -55.918 26.825  22.798 1.00 19.19  ? 58   ASP B CA    1 ? 
ATOM   4571 C C     . ASP B 1 79  ? -56.340 26.461  24.214 1.00 17.21  ? 58   ASP B C     1 ? 
ATOM   4572 O O     . ASP B 1 79  ? -57.522 26.365  24.471 1.00 19.98  ? 58   ASP B O     1 ? 
ATOM   4573 C CB    . ASP B 1 79  ? -56.163 28.295  22.482 1.00 20.32  ? 58   ASP B CB    1 ? 
ATOM   4574 C CG    . ASP B 1 79  ? -55.403 29.387  23.230 1.00 20.15  ? 58   ASP B CG    1 ? 
ATOM   4575 O OD1   . ASP B 1 79  ? -54.622 29.082  24.136 1.00 18.71  ? 58   ASP B OD1   1 ? 
ATOM   4576 O OD2   . ASP B 1 79  ? -55.600 30.556  22.872 1.00 20.74  ? 58   ASP B OD2   1 ? 
ATOM   4577 N N     . TRP B 1 80  ? -55.372 26.288  25.141 1.00 18.69  ? 59   TRP B N     1 ? 
ATOM   4578 C CA    . TRP B 1 80  ? -55.666 26.083  26.562 1.00 17.27  ? 59   TRP B CA    1 ? 
ATOM   4579 C C     . TRP B 1 80  ? -56.211 27.356  27.224 1.00 16.21  ? 59   TRP B C     1 ? 
ATOM   4580 O O     . TRP B 1 80  ? -56.773 27.268  28.306 1.00 16.05  ? 59   TRP B O     1 ? 
ATOM   4581 C CB    . TRP B 1 80  ? -54.433 25.516  27.299 1.00 17.39  ? 59   TRP B CB    1 ? 
ATOM   4582 C CG    . TRP B 1 80  ? -54.044 24.117  26.897 1.00 17.22  ? 59   TRP B CG    1 ? 
ATOM   4583 C CD1   . TRP B 1 80  ? -53.277 23.751  25.823 1.00 17.13  ? 59   TRP B CD1   1 ? 
ATOM   4584 C CD2   . TRP B 1 80  ? -54.443 22.877  27.533 1.00 19.28  ? 59   TRP B CD2   1 ? 
ATOM   4585 N NE1   . TRP B 1 80  ? -53.158 22.386  25.746 1.00 18.47  ? 59   TRP B NE1   1 ? 
ATOM   4586 C CE2   . TRP B 1 80  ? -53.865 21.819  26.781 1.00 19.79  ? 59   TRP B CE2   1 ? 
ATOM   4587 C CE3   . TRP B 1 80  ? -55.235 22.557  28.647 1.00 20.71  ? 59   TRP B CE3   1 ? 
ATOM   4588 C CZ2   . TRP B 1 80  ? -54.067 20.480  27.104 1.00 19.48  ? 59   TRP B CZ2   1 ? 
ATOM   4589 C CZ3   . TRP B 1 80  ? -55.428 21.227  28.967 1.00 21.53  ? 59   TRP B CZ3   1 ? 
ATOM   4590 C CH2   . TRP B 1 80  ? -54.849 20.202  28.204 1.00 20.86  ? 59   TRP B CH2   1 ? 
ATOM   4591 N N     . THR B 1 81  ? -55.960 28.536  26.613 1.00 17.83  ? 60   THR B N     1 ? 
ATOM   4592 C CA    . THR B 1 81  ? -56.494 29.851  26.975 1.00 17.40  ? 60   THR B CA    1 ? 
ATOM   4593 C C     . THR B 1 81  ? -56.125 30.249  28.402 1.00 15.84  ? 60   THR B C     1 ? 
ATOM   4594 O O     . THR B 1 81  ? -56.885 30.957  29.049 1.00 18.29  ? 60   THR B O     1 ? 
ATOM   4595 C CB    . THR B 1 81  ? -58.005 29.984  26.733 1.00 19.80  ? 60   THR B CB    1 ? 
ATOM   4596 O OG1   . THR B 1 81  ? -58.743 29.267  27.744 1.00 18.77  ? 60   THR B OG1   1 ? 
ATOM   4597 C CG2   . THR B 1 81  ? -58.402 29.522  25.335 1.00 17.66  ? 60   THR B CG2   1 ? 
ATOM   4598 N N     . TYR B 1 82  ? -54.934 29.876  28.868 1.00 17.22  ? 61   TYR B N     1 ? 
ATOM   4599 C CA    . TYR B 1 82  ? -54.472 30.322  30.190 1.00 17.71  ? 61   TYR B CA    1 ? 
ATOM   4600 C C     . TYR B 1 82  ? -54.072 31.801  30.139 1.00 18.09  ? 61   TYR B C     1 ? 
ATOM   4601 O O     . TYR B 1 82  ? -53.663 32.310  29.096 1.00 16.58  ? 61   TYR B O     1 ? 
ATOM   4602 C CB    . TYR B 1 82  ? -53.248 29.532  30.631 1.00 16.66  ? 61   TYR B CB    1 ? 
ATOM   4603 C CG    . TYR B 1 82  ? -53.406 28.032  30.780 1.00 16.66  ? 61   TYR B CG    1 ? 
ATOM   4604 C CD1   . TYR B 1 82  ? -54.596 27.436  31.195 1.00 17.08  ? 61   TYR B CD1   1 ? 
ATOM   4605 C CD2   . TYR B 1 82  ? -52.314 27.205  30.564 1.00 18.05  ? 61   TYR B CD2   1 ? 
ATOM   4606 C CE1   . TYR B 1 82  ? -54.704 26.068  31.368 1.00 16.95  ? 61   TYR B CE1   1 ? 
ATOM   4607 C CE2   . TYR B 1 82  ? -52.413 25.839  30.721 1.00 16.01  ? 61   TYR B CE2   1 ? 
ATOM   4608 C CZ    . TYR B 1 82  ? -53.592 25.265  31.156 1.00 17.03  ? 61   TYR B CZ    1 ? 
ATOM   4609 O OH    . TYR B 1 82  ? -53.558 23.912  31.356 1.00 16.64  ? 61   TYR B OH    1 ? 
ATOM   4610 N N     . SER B 1 83  ? -54.151 32.470  31.291 1.00 19.43  ? 62   SER B N     1 ? 
ATOM   4611 C CA    . SER B 1 83  ? -53.520 33.773  31.504 1.00 20.15  ? 62   SER B CA    1 ? 
ATOM   4612 C C     . SER B 1 83  ? -52.635 33.688  32.751 1.00 20.53  ? 62   SER B C     1 ? 
ATOM   4613 O O     . SER B 1 83  ? -52.885 32.865  33.631 1.00 18.42  ? 62   SER B O     1 ? 
ATOM   4614 C CB    . SER B 1 83  ? -54.548 34.856  31.703 1.00 19.80  ? 62   SER B CB    1 ? 
ATOM   4615 O OG    . SER B 1 83  ? -55.210 35.180  30.502 1.00 21.25  ? 62   SER B OG    1 ? 
ATOM   4616 N N     . SER B 1 84  ? -51.650 34.590  32.856 1.00 18.76  ? 63   SER B N     1 ? 
ATOM   4617 C CA    . SER B 1 84  ? -50.893 34.703  34.088 1.00 18.28  ? 63   SER B CA    1 ? 
ATOM   4618 C C     . SER B 1 84  ? -51.751 35.263  35.217 1.00 17.94  ? 63   SER B C     1 ? 
ATOM   4619 O O     . SER B 1 84  ? -52.756 35.942  35.003 1.00 19.05  ? 63   SER B O     1 ? 
ATOM   4620 C CB    . SER B 1 84  ? -49.672 35.583  33.910 1.00 18.06  ? 63   SER B CB    1 ? 
ATOM   4621 O OG    . SER B 1 84  ? -50.039 36.957  33.850 1.00 17.53  ? 63   SER B OG    1 ? 
ATOM   4622 N N     . VAL B 1 85  ? -51.278 35.040  36.439 1.00 18.71  ? 64   VAL B N     1 ? 
ATOM   4623 C CA    . VAL B 1 85  ? -51.749 35.802  37.583 1.00 19.11  ? 64   VAL B CA    1 ? 
ATOM   4624 C C     . VAL B 1 85  ? -51.399 37.265  37.323 1.00 18.57  ? 64   VAL B C     1 ? 
ATOM   4625 O O     . VAL B 1 85  ? -50.542 37.584  36.499 1.00 15.16  ? 64   VAL B O     1 ? 
ATOM   4626 C CB    . VAL B 1 85  ? -51.143 35.316  38.914 1.00 20.46  ? 64   VAL B CB    1 ? 
ATOM   4627 C CG1   . VAL B 1 85  ? -51.354 33.817  39.119 1.00 22.75  ? 64   VAL B CG1   1 ? 
ATOM   4628 C CG2   . VAL B 1 85  ? -49.676 35.671  39.050 1.00 20.36  ? 64   VAL B CG2   1 ? 
ATOM   4629 N N     . GLU B 1 86  ? -52.095 38.162  38.005 1.00 20.18  ? 65   GLU B N     1 ? 
ATOM   4630 C CA    . GLU B 1 86  ? -51.787 39.587  37.888 1.00 22.57  ? 65   GLU B CA    1 ? 
ATOM   4631 C C     . GLU B 1 86  ? -50.304 39.838  38.142 1.00 18.89  ? 65   GLU B C     1 ? 
ATOM   4632 O O     . GLU B 1 86  ? -49.758 39.339  39.113 1.00 19.22  ? 65   GLU B O     1 ? 
ATOM   4633 C CB    . GLU B 1 86  ? -52.618 40.377  38.906 1.00 25.83  ? 65   GLU B CB    1 ? 
ATOM   4634 C CG    . GLU B 1 86  ? -54.114 40.316  38.649 1.00 31.85  ? 65   GLU B CG    1 ? 
ATOM   4635 C CD    . GLU B 1 86  ? -54.892 40.695  39.905 1.00 39.75  ? 65   GLU B CD    1 ? 
ATOM   4636 O OE1   . GLU B 1 86  ? -55.755 41.583  39.777 1.00 36.71  ? 65   GLU B OE1   1 ? 
ATOM   4637 O OE2   . GLU B 1 86  ? -54.595 40.143  41.001 1.00 43.11  ? 65   GLU B OE2   1 ? 
ATOM   4638 N N     . GLN B 1 87  ? -49.653 40.602  37.264 1.00 18.17  ? 66   GLN B N     1 ? 
ATOM   4639 C CA    . GLN B 1 87  ? -48.219 40.824  37.335 1.00 18.94  ? 66   GLN B CA    1 ? 
ATOM   4640 C C     . GLN B 1 87  ? -47.907 42.205  37.895 1.00 20.93  ? 66   GLN B C     1 ? 
ATOM   4641 O O     . GLN B 1 87  ? -48.200 43.203  37.216 1.00 20.52  ? 66   GLN B O     1 ? 
ATOM   4642 C CB    . GLN B 1 87  ? -47.675 40.684  35.917 1.00 18.54  ? 66   GLN B CB    1 ? 
ATOM   4643 C CG    . GLN B 1 87  ? -47.767 39.258  35.394 1.00 19.84  ? 66   GLN B CG    1 ? 
ATOM   4644 C CD    . GLN B 1 87  ? -46.920 38.303  36.217 1.00 18.30  ? 66   GLN B CD    1 ? 
ATOM   4645 O OE1   . GLN B 1 87  ? -45.712 38.431  36.260 1.00 20.22  ? 66   GLN B OE1   1 ? 
ATOM   4646 N NE2   . GLN B 1 87  ? -47.528 37.327  36.862 1.00 18.76  ? 66   GLN B NE2   1 ? 
ATOM   4647 N N     . THR B 1 88  ? -47.325 42.274  39.108 1.00 20.88  ? 67   THR B N     1 ? 
ATOM   4648 C CA    . THR B 1 88  ? -47.142 43.567  39.768 1.00 24.89  ? 67   THR B CA    1 ? 
ATOM   4649 C C     . THR B 1 88  ? -46.185 44.450  38.967 1.00 24.54  ? 67   THR B C     1 ? 
ATOM   4650 O O     . THR B 1 88  ? -46.345 45.685  38.926 1.00 29.32  ? 67   THR B O     1 ? 
ATOM   4651 C CB    . THR B 1 88  ? -46.677 43.438  41.222 1.00 30.83  ? 67   THR B CB    1 ? 
ATOM   4652 O OG1   . THR B 1 88  ? -45.533 42.612  41.150 1.00 31.61  ? 67   THR B OG1   1 ? 
ATOM   4653 C CG2   . THR B 1 88  ? -47.738 42.851  42.140 1.00 36.72  ? 67   THR B CG2   1 ? 
ATOM   4654 N N     . GLY B 1 89  ? -45.248 43.832  38.242 1.00 21.81  ? 68   GLY B N     1 ? 
ATOM   4655 C CA    . GLY B 1 89  ? -44.284 44.611  37.473 1.00 23.46  ? 68   GLY B CA    1 ? 
ATOM   4656 C C     . GLY B 1 89  ? -44.856 45.108  36.145 1.00 21.87  ? 68   GLY B C     1 ? 
ATOM   4657 O O     . GLY B 1 89  ? -44.255 45.978  35.506 1.00 23.39  ? 68   GLY B O     1 ? 
ATOM   4658 N N     . LEU B 1 90  ? -46.014 44.552  35.740 1.00 20.47  ? 69   LEU B N     1 ? 
ATOM   4659 C CA    . LEU B 1 90  ? -46.731 44.994  34.555 1.00 20.72  ? 69   LEU B CA    1 ? 
ATOM   4660 C C     . LEU B 1 90  ? -48.059 45.663  34.927 1.00 22.66  ? 69   LEU B C     1 ? 
ATOM   4661 O O     . LEU B 1 90  ? -49.072 45.456  34.268 1.00 24.28  ? 69   LEU B O     1 ? 
ATOM   4662 C CB    . LEU B 1 90  ? -46.925 43.780  33.635 1.00 21.38  ? 69   LEU B CB    1 ? 
ATOM   4663 C CG    . LEU B 1 90  ? -45.660 43.196  32.995 1.00 20.14  ? 69   LEU B CG    1 ? 
ATOM   4664 C CD1   . LEU B 1 90  ? -45.984 41.993  32.106 1.00 19.95  ? 69   LEU B CD1   1 ? 
ATOM   4665 C CD2   . LEU B 1 90  ? -44.801 44.209  32.205 1.00 22.12  ? 69   LEU B CD2   1 ? 
ATOM   4666 N N     . ASN B 1 91  ? -48.079 46.446  36.012 1.00 21.07  ? 70   ASN B N     1 ? 
ATOM   4667 C CA    . ASN B 1 91  ? -49.250 47.230  36.374 1.00 21.39  ? 70   ASN B CA    1 ? 
ATOM   4668 C C     . ASN B 1 91  ? -50.436 46.323  36.675 1.00 22.26  ? 70   ASN B C     1 ? 
ATOM   4669 O O     . ASN B 1 91  ? -51.581 46.675  36.421 1.00 22.55  ? 70   ASN B O     1 ? 
ATOM   4670 C CB    . ASN B 1 91  ? -49.603 48.264  35.307 1.00 25.34  ? 70   ASN B CB    1 ? 
ATOM   4671 C CG    . ASN B 1 91  ? -48.596 49.383  35.247 1.00 28.49  ? 70   ASN B CG    1 ? 
ATOM   4672 O OD1   . ASN B 1 91  ? -47.653 49.442  36.055 1.00 25.68  ? 70   ASN B OD1   1 ? 
ATOM   4673 N ND2   . ASN B 1 91  ? -48.740 50.221  34.236 1.00 33.99  ? 70   ASN B ND2   1 ? 
ATOM   4674 N N     . ASN B 1 92  ? -50.157 45.166  37.272 1.00 22.66  ? 71   ASN B N     1 ? 
ATOM   4675 C CA    . ASN B 1 92  ? -51.177 44.211  37.660 1.00 24.72  ? 71   ASN B CA    1 ? 
ATOM   4676 C C     . ASN B 1 92  ? -51.964 43.643  36.480 1.00 23.15  ? 71   ASN B C     1 ? 
ATOM   4677 O O     . ASN B 1 92  ? -53.027 43.058  36.694 1.00 26.10  ? 71   ASN B O     1 ? 
ATOM   4678 C CB    . ASN B 1 92  ? -52.062 44.761  38.776 1.00 25.76  ? 71   ASN B CB    1 ? 
ATOM   4679 C CG    . ASN B 1 92  ? -51.491 44.393  40.124 1.00 28.24  ? 71   ASN B CG    1 ? 
ATOM   4680 O OD1   . ASN B 1 92  ? -50.775 43.381  40.211 1.00 26.30  ? 71   ASN B OD1   1 ? 
ATOM   4681 N ND2   . ASN B 1 92  ? -51.889 45.107  41.174 1.00 26.61  ? 71   ASN B ND2   1 ? 
ATOM   4682 N N     . ARG B 1 93  ? -51.415 43.734  35.269 1.00 22.74  ? 72   ARG B N     1 ? 
ATOM   4683 C CA    . ARG B 1 93  ? -52.032 43.071  34.132 1.00 22.92  ? 72   ARG B CA    1 ? 
ATOM   4684 C C     . ARG B 1 93  ? -51.908 41.549  34.257 1.00 20.50  ? 72   ARG B C     1 ? 
ATOM   4685 O O     . ARG B 1 93  ? -50.921 41.018  34.769 1.00 20.21  ? 72   ARG B O     1 ? 
ATOM   4686 C CB    . ARG B 1 93  ? -51.364 43.514  32.825 1.00 23.50  ? 72   ARG B CB    1 ? 
ATOM   4687 C CG    . ARG B 1 93  ? -51.804 44.931  32.508 1.00 26.98  ? 72   ARG B CG    1 ? 
ATOM   4688 C CD    . ARG B 1 93  ? -51.327 45.432  31.181 1.00 32.01  ? 72   ARG B CD    1 ? 
ATOM   4689 N NE    . ARG B 1 93  ? -49.878 45.348  31.092 1.00 29.63  ? 72   ARG B NE    1 ? 
ATOM   4690 C CZ    . ARG B 1 93  ? -49.114 44.861  30.104 1.00 27.35  ? 72   ARG B CZ    1 ? 
ATOM   4691 N NH1   . ARG B 1 93  ? -49.524 44.123  29.091 1.00 29.70  ? 72   ARG B NH1   1 ? 
ATOM   4692 N NH2   . ARG B 1 93  ? -47.846 45.139  30.174 1.00 25.73  ? 72   ARG B NH2   1 ? 
ATOM   4693 N N     . SER B 1 94  ? -52.970 40.868  33.832 1.00 19.66  ? 73   SER B N     1 ? 
ATOM   4694 C CA    . SER B 1 94  ? -52.966 39.419  33.705 1.00 22.77  ? 73   SER B CA    1 ? 
ATOM   4695 C C     . SER B 1 94  ? -52.597 39.103  32.253 1.00 24.29  ? 73   SER B C     1 ? 
ATOM   4696 O O     . SER B 1 94  ? -53.277 39.589  31.354 1.00 25.62  ? 73   SER B O     1 ? 
ATOM   4697 C CB    . SER B 1 94  ? -54.313 38.883  34.132 1.00 26.04  ? 73   SER B CB    1 ? 
ATOM   4698 O OG    . SER B 1 94  ? -54.420 37.519  33.759 1.00 34.27  ? 73   SER B OG    1 ? 
ATOM   4699 N N     . ILE B 1 95  ? -51.462 38.426  32.012 1.00 20.56  ? 74   ILE B N     1 ? 
ATOM   4700 C CA    . ILE B 1 95  ? -50.927 38.301  30.661 1.00 21.42  ? 74   ILE B CA    1 ? 
ATOM   4701 C C     . ILE B 1 95  ? -51.473 37.031  30.008 1.00 19.44  ? 74   ILE B C     1 ? 
ATOM   4702 O O     . ILE B 1 95  ? -51.220 35.935  30.487 1.00 19.12  ? 74   ILE B O     1 ? 
ATOM   4703 C CB    . ILE B 1 95  ? -49.399 38.353  30.643 1.00 22.06  ? 74   ILE B CB    1 ? 
ATOM   4704 C CG1   . ILE B 1 95  ? -48.846 39.653  31.323 1.00 25.12  ? 74   ILE B CG1   1 ? 
ATOM   4705 C CG2   . ILE B 1 95  ? -48.854 38.141  29.224 1.00 21.26  ? 74   ILE B CG2   1 ? 
ATOM   4706 C CD1   . ILE B 1 95  ? -49.328 40.946  30.689 1.00 27.66  ? 74   ILE B CD1   1 ? 
ATOM   4707 N N     . TYR B 1 96  ? -52.197 37.226  28.894 1.00 18.43  ? 75   TYR B N     1 ? 
ATOM   4708 C CA    . TYR B 1 96  ? -52.726 36.125  28.103 1.00 18.95  ? 75   TYR B CA    1 ? 
ATOM   4709 C C     . TYR B 1 96  ? -51.562 35.260  27.635 1.00 17.68  ? 75   TYR B C     1 ? 
ATOM   4710 O O     . TYR B 1 96  ? -50.609 35.748  26.993 1.00 16.70  ? 75   TYR B O     1 ? 
ATOM   4711 C CB    . TYR B 1 96  ? -53.570 36.613  26.919 1.00 20.62  ? 75   TYR B CB    1 ? 
ATOM   4712 C CG    . TYR B 1 96  ? -54.346 35.482  26.248 1.00 22.88  ? 75   TYR B CG    1 ? 
ATOM   4713 C CD1   . TYR B 1 96  ? -55.203 34.686  26.996 1.00 23.14  ? 75   TYR B CD1   1 ? 
ATOM   4714 C CD2   . TYR B 1 96  ? -54.169 35.156  24.906 1.00 24.16  ? 75   TYR B CD2   1 ? 
ATOM   4715 C CE1   . TYR B 1 96  ? -55.896 33.635  26.425 1.00 23.63  ? 75   TYR B CE1   1 ? 
ATOM   4716 C CE2   . TYR B 1 96  ? -54.844 34.086  24.326 1.00 23.01  ? 75   TYR B CE2   1 ? 
ATOM   4717 C CZ    . TYR B 1 96  ? -55.704 33.317  25.098 1.00 23.76  ? 75   TYR B CZ    1 ? 
ATOM   4718 O OH    . TYR B 1 96  ? -56.460 32.276  24.632 1.00 22.90  ? 75   TYR B OH    1 ? 
ATOM   4719 N N     . SER B 1 97  ? -51.639 33.980  27.989 1.00 16.38  ? 76   SER B N     1 ? 
ATOM   4720 C CA    . SER B 1 97  ? -50.522 33.045  27.900 1.00 16.00  ? 76   SER B CA    1 ? 
ATOM   4721 C C     . SER B 1 97  ? -50.976 31.780  27.165 1.00 17.15  ? 76   SER B C     1 ? 
ATOM   4722 O O     . SER B 1 97  ? -51.055 30.695  27.741 1.00 17.31  ? 76   SER B O     1 ? 
ATOM   4723 C CB    . SER B 1 97  ? -50.011 32.716  29.277 1.00 17.70  ? 76   SER B CB    1 ? 
ATOM   4724 O OG    . SER B 1 97  ? -49.487 33.879  29.934 1.00 17.69  ? 76   SER B OG    1 ? 
ATOM   4725 N N     . PRO B 1 98  ? -51.322 31.883  25.869 1.00 17.21  ? 77   PRO B N     1 ? 
ATOM   4726 C CA    . PRO B 1 98  ? -51.884 30.754  25.136 1.00 18.29  ? 77   PRO B CA    1 ? 
ATOM   4727 C C     . PRO B 1 98  ? -50.867 29.635  24.972 1.00 16.87  ? 77   PRO B C     1 ? 
ATOM   4728 O O     . PRO B 1 98  ? -49.661 29.848  25.015 1.00 17.31  ? 77   PRO B O     1 ? 
ATOM   4729 C CB    . PRO B 1 98  ? -52.299 31.377  23.800 1.00 18.20  ? 77   PRO B CB    1 ? 
ATOM   4730 C CG    . PRO B 1 98  ? -51.374 32.577  23.650 1.00 18.40  ? 77   PRO B CG    1 ? 
ATOM   4731 C CD    . PRO B 1 98  ? -51.172 33.076  25.038 1.00 17.86  ? 77   PRO B CD    1 ? 
ATOM   4732 N N     . SER B 1 99  ? -51.388 28.443  24.694 1.00 18.56  ? 78   SER B N     1 ? 
ATOM   4733 C CA    . SER B 1 99  ? -50.613 27.269  24.366 1.00 18.37  ? 78   SER B CA    1 ? 
ATOM   4734 C C     . SER B 1 99  ? -51.514 26.334  23.570 1.00 18.84  ? 78   SER B C     1 ? 
ATOM   4735 O O     . SER B 1 99  ? -52.732 26.317  23.761 1.00 18.60  ? 78   SER B O     1 ? 
ATOM   4736 C CB    . SER B 1 99  ? -50.097 26.607  25.610 1.00 19.17  ? 78   SER B CB    1 ? 
ATOM   4737 O OG    . SER B 1 99  ? -51.146 26.446  26.564 1.00 19.20  ? 78   SER B OG    1 ? 
ATOM   4738 N N     . GLY B 1 100 ? -50.906 25.567  22.667 1.00 17.36  ? 79   GLY B N     1 ? 
ATOM   4739 C CA    . GLY B 1 100 ? -51.652 24.788  21.699 1.00 17.65  ? 79   GLY B CA    1 ? 
ATOM   4740 C C     . GLY B 1 100 ? -52.302 23.551  22.314 1.00 16.78  ? 79   GLY B C     1 ? 
ATOM   4741 O O     . GLY B 1 100 ? -51.705 22.883  23.172 1.00 19.35  ? 79   GLY B O     1 ? 
ATOM   4742 N N     . LYS B 1 101 ? -53.508 23.243  21.835 1.00 17.97  ? 80   LYS B N     1 ? 
ATOM   4743 C CA    . LYS B 1 101 ? -54.242 22.050  22.273 1.00 19.13  ? 80   LYS B CA    1 ? 
ATOM   4744 C C     . LYS B 1 101 ? -54.742 21.343  21.022 1.00 17.66  ? 80   LYS B C     1 ? 
ATOM   4745 O O     . LYS B 1 101 ? -55.872 21.522  20.593 1.00 19.10  ? 80   LYS B O     1 ? 
ATOM   4746 C CB    . LYS B 1 101 ? -55.374 22.365  23.249 1.00 18.80  ? 80   LYS B CB    1 ? 
ATOM   4747 C CG    . LYS B 1 101 ? -56.016 21.111  23.901 1.00 22.01  ? 80   LYS B CG    1 ? 
ATOM   4748 C CD    . LYS B 1 101 ? -56.994 21.411  25.051 1.00 24.64  ? 80   LYS B CD    1 ? 
ATOM   4749 C CE    . LYS B 1 101 ? -58.102 22.360  24.742 1.00 29.04  ? 80   LYS B CE    1 ? 
ATOM   4750 N NZ    . LYS B 1 101 ? -59.130 22.482  25.794 1.00 27.19  ? 80   LYS B NZ    1 ? 
ATOM   4751 N N     . VAL B 1 102 ? -53.849 20.566  20.439 1.00 19.53  ? 81   VAL B N     1 ? 
ATOM   4752 C CA    . VAL B 1 102 ? -54.007 20.007  19.103 1.00 19.90  ? 81   VAL B CA    1 ? 
ATOM   4753 C C     . VAL B 1 102 ? -52.722 19.225  18.878 1.00 19.59  ? 81   VAL B C     1 ? 
ATOM   4754 O O     . VAL B 1 102 ? -51.705 19.499  19.531 1.00 18.30  ? 81   VAL B O     1 ? 
ATOM   4755 C CB    . VAL B 1 102 ? -54.230 21.122  18.045 1.00 18.85  ? 81   VAL B CB    1 ? 
ATOM   4756 C CG1   . VAL B 1 102 ? -53.029 22.039  17.922 1.00 18.26  ? 81   VAL B CG1   1 ? 
ATOM   4757 C CG2   . VAL B 1 102 ? -54.589 20.596  16.658 1.00 19.68  ? 81   VAL B CG2   1 ? 
ATOM   4758 N N     . VAL B 1 103 ? -52.778 18.204  18.024 1.00 18.98  ? 82   VAL B N     1 ? 
ATOM   4759 C CA    . VAL B 1 103 ? -51.566 17.617  17.491 1.00 18.34  ? 82   VAL B CA    1 ? 
ATOM   4760 C C     . VAL B 1 103 ? -50.742 18.731  16.837 1.00 19.84  ? 82   VAL B C     1 ? 
ATOM   4761 O O     . VAL B 1 103 ? -51.175 19.408  15.906 1.00 22.59  ? 82   VAL B O     1 ? 
ATOM   4762 C CB    . VAL B 1 103 ? -51.848 16.452  16.529 1.00 20.94  ? 82   VAL B CB    1 ? 
ATOM   4763 C CG1   . VAL B 1 103 ? -50.571 15.946  15.881 1.00 23.06  ? 82   VAL B CG1   1 ? 
ATOM   4764 C CG2   . VAL B 1 103 ? -52.537 15.308  17.247 1.00 20.44  ? 82   VAL B CG2   1 ? 
ATOM   4765 N N     . GLY B 1 104 ? -49.540 18.958  17.377 1.00 20.14  ? 83   GLY B N     1 ? 
ATOM   4766 C CA    . GLY B 1 104 ? -48.724 20.089  16.985 1.00 19.34  ? 83   GLY B CA    1 ? 
ATOM   4767 C C     . GLY B 1 104 ? -48.501 21.049  18.156 1.00 21.35  ? 83   GLY B C     1 ? 
ATOM   4768 O O     . GLY B 1 104 ? -47.555 21.835  18.155 1.00 19.98  ? 83   GLY B O     1 ? 
ATOM   4769 N N     . GLY B 1 105 ? -49.357 20.960  19.169 1.00 20.50  ? 84   GLY B N     1 ? 
ATOM   4770 C CA    . GLY B 1 105 ? -49.261 21.860  20.295 1.00 21.37  ? 84   GLY B CA    1 ? 
ATOM   4771 C C     . GLY B 1 105 ? -49.108 23.312  19.840 1.00 19.47  ? 84   GLY B C     1 ? 
ATOM   4772 O O     . GLY B 1 105 ? -49.794 23.797  18.926 1.00 19.99  ? 84   GLY B O     1 ? 
ATOM   4773 N N     . SER B 1 106 ? -48.190 24.024  20.492 1.00 18.61  ? 85   SER B N     1 ? 
ATOM   4774 C CA    . SER B 1 106 ? -48.074 25.445  20.251 1.00 16.85  ? 85   SER B CA    1 ? 
ATOM   4775 C C     . SER B 1 106 ? -47.490 25.700  18.866 1.00 18.09  ? 85   SER B C     1 ? 
ATOM   4776 O O     . SER B 1 106 ? -47.679 26.784  18.326 1.00 18.63  ? 85   SER B O     1 ? 
ATOM   4777 C CB    . SER B 1 106 ? -47.278 26.143  21.347 1.00 18.21  ? 85   SER B CB    1 ? 
ATOM   4778 O OG    . SER B 1 106 ? -47.982 26.098  22.576 1.00 17.89  ? 85   SER B OG    1 ? 
ATOM   4779 N N     . SER B 1 107 ? -46.801 24.714  18.278 1.00 18.41  ? 86   SER B N     1 ? 
ATOM   4780 C CA    . SER B 1 107 ? -46.317 24.885  16.910 1.00 20.70  ? 86   SER B CA    1 ? 
ATOM   4781 C C     . SER B 1 107 ? -47.477 24.978  15.912 1.00 21.81  ? 86   SER B C     1 ? 
ATOM   4782 O O     . SER B 1 107 ? -47.252 25.391  14.780 1.00 20.24  ? 86   SER B O     1 ? 
ATOM   4783 C CB    . SER B 1 107 ? -45.351 23.803  16.505 1.00 21.10  ? 86   SER B CB    1 ? 
ATOM   4784 O OG    . SER B 1 107 ? -45.976 22.563  16.219 1.00 22.12  ? 86   SER B OG    1 ? 
ATOM   4785 N N     . ALA B 1 108 ? -48.702 24.596  16.335 1.00 20.08  ? 87   ALA B N     1 ? 
ATOM   4786 C CA    . ALA B 1 108 ? -49.885 24.649  15.476 1.00 20.40  ? 87   ALA B CA    1 ? 
ATOM   4787 C C     . ALA B 1 108 ? -50.578 25.995  15.551 1.00 19.91  ? 87   ALA B C     1 ? 
ATOM   4788 O O     . ALA B 1 108 ? -51.476 26.241  14.751 1.00 20.59  ? 87   ALA B O     1 ? 
ATOM   4789 C CB    . ALA B 1 108 ? -50.862 23.543  15.824 1.00 19.70  ? 87   ALA B CB    1 ? 
ATOM   4790 N N     . ILE B 1 109 ? -50.179 26.867  16.492 1.00 20.50  ? 88   ILE B N     1 ? 
ATOM   4791 C CA    . ILE B 1 109 ? -50.886 28.133  16.697 1.00 21.56  ? 88   ILE B CA    1 ? 
ATOM   4792 C C     . ILE B 1 109 ? -49.924 29.312  16.814 1.00 20.88  ? 88   ILE B C     1 ? 
ATOM   4793 O O     . ILE B 1 109 ? -50.362 30.380  17.286 1.00 22.15  ? 88   ILE B O     1 ? 
ATOM   4794 C CB    . ILE B 1 109 ? -51.793 28.085  17.943 1.00 21.50  ? 88   ILE B CB    1 ? 
ATOM   4795 C CG1   . ILE B 1 109 ? -50.975 27.989  19.256 1.00 23.36  ? 88   ILE B CG1   1 ? 
ATOM   4796 C CG2   . ILE B 1 109 ? -52.804 26.942  17.817 1.00 22.16  ? 88   ILE B CG2   1 ? 
ATOM   4797 C CD1   . ILE B 1 109 ? -51.793 28.269  20.504 1.00 24.30  ? 88   ILE B CD1   1 ? 
ATOM   4798 N N     . ASN B 1 110 ? -48.670 29.140  16.380 1.00 21.06  ? 89   ASN B N     1 ? 
ATOM   4799 C CA    . ASN B 1 110 ? -47.661 30.191  16.524 1.00 22.10  ? 89   ASN B CA    1 ? 
ATOM   4800 C C     . ASN B 1 110 ? -47.437 30.903  15.195 1.00 21.80  ? 89   ASN B C     1 ? 
ATOM   4801 O O     . ASN B 1 110 ? -47.964 30.482  14.160 1.00 24.16  ? 89   ASN B O     1 ? 
ATOM   4802 C CB    . ASN B 1 110 ? -46.361 29.671  17.158 1.00 22.71  ? 89   ASN B CB    1 ? 
ATOM   4803 C CG    . ASN B 1 110 ? -45.606 28.636  16.358 1.00 21.50  ? 89   ASN B CG    1 ? 
ATOM   4804 O OD1   . ASN B 1 110 ? -45.880 28.425  15.171 1.00 21.55  ? 89   ASN B OD1   1 ? 
ATOM   4805 N ND2   . ASN B 1 110 ? -44.617 28.009  16.971 1.00 21.71  ? 89   ASN B ND2   1 ? 
ATOM   4806 N N     . VAL B 1 111 ? -46.617 31.970  15.215 1.00 20.32  ? 90   VAL B N     1 ? 
ATOM   4807 C CA    . VAL B 1 111 ? -46.266 32.670  13.990 1.00 20.82  ? 90   VAL B CA    1 ? 
ATOM   4808 C C     . VAL B 1 111 ? -45.530 31.692  13.078 1.00 21.40  ? 90   VAL B C     1 ? 
ATOM   4809 O O     . VAL B 1 111 ? -45.868 31.580  11.892 1.00 23.59  ? 90   VAL B O     1 ? 
ATOM   4810 C CB    . VAL B 1 111 ? -45.422 33.927  14.246 1.00 25.31  ? 90   VAL B CB    1 ? 
ATOM   4811 C CG1   . VAL B 1 111 ? -44.979 34.553  12.923 1.00 27.33  ? 90   VAL B CG1   1 ? 
ATOM   4812 C CG2   . VAL B 1 111 ? -46.154 34.938  15.119 1.00 27.52  ? 90   VAL B CG2   1 ? 
ATOM   4813 N N     . GLY B 1 112 ? -44.584 30.951  13.682 1.00 21.94  ? 91   GLY B N     1 ? 
ATOM   4814 C CA    . GLY B 1 112 ? -43.901 29.816  13.076 1.00 22.79  ? 91   GLY B CA    1 ? 
ATOM   4815 C C     . GLY B 1 112 ? -42.445 30.145  12.738 1.00 23.81  ? 91   GLY B C     1 ? 
ATOM   4816 O O     . GLY B 1 112 ? -41.821 29.426  11.960 1.00 24.50  ? 91   GLY B O     1 ? 
ATOM   4817 N N     . VAL B 1 113 ? -41.893 31.199  13.353 1.00 23.01  ? 92   VAL B N     1 ? 
ATOM   4818 C CA    . VAL B 1 113 ? -40.527 31.625  13.082 1.00 23.15  ? 92   VAL B CA    1 ? 
ATOM   4819 C C     . VAL B 1 113 ? -39.557 30.624  13.698 1.00 24.46  ? 92   VAL B C     1 ? 
ATOM   4820 O O     . VAL B 1 113 ? -39.790 30.081  14.781 1.00 22.48  ? 92   VAL B O     1 ? 
ATOM   4821 C CB    . VAL B 1 113 ? -40.213 33.068  13.511 1.00 24.01  ? 92   VAL B CB    1 ? 
ATOM   4822 C CG1   . VAL B 1 113 ? -41.134 34.060  12.809 1.00 27.33  ? 92   VAL B CG1   1 ? 
ATOM   4823 C CG2   . VAL B 1 113 ? -40.247 33.251  15.023 1.00 24.88  ? 92   VAL B CG2   1 ? 
ATOM   4824 N N     . TRP B 1 114 ? -38.506 30.308  12.934 1.00 24.59  ? 93   TRP B N     1 ? 
ATOM   4825 C CA    . TRP B 1 114 ? -37.495 29.354  13.354 1.00 22.88  ? 93   TRP B CA    1 ? 
ATOM   4826 C C     . TRP B 1 114 ? -36.226 30.138  13.631 1.00 26.26  ? 93   TRP B C     1 ? 
ATOM   4827 O O     . TRP B 1 114 ? -35.485 30.482  12.701 1.00 23.41  ? 93   TRP B O     1 ? 
ATOM   4828 C CB    . TRP B 1 114 ? -37.256 28.316  12.258 1.00 22.47  ? 93   TRP B CB    1 ? 
ATOM   4829 C CG    . TRP B 1 114 ? -36.368 27.165  12.649 1.00 21.69  ? 93   TRP B CG    1 ? 
ATOM   4830 C CD1   . TRP B 1 114 ? -35.023 27.050  12.506 1.00 20.39  ? 93   TRP B CD1   1 ? 
ATOM   4831 C CD2   . TRP B 1 114 ? -36.810 25.914  13.230 1.00 23.19  ? 93   TRP B CD2   1 ? 
ATOM   4832 N NE1   . TRP B 1 114 ? -34.592 25.836  12.966 1.00 23.21  ? 93   TRP B NE1   1 ? 
ATOM   4833 C CE2   . TRP B 1 114 ? -35.670 25.107  13.391 1.00 23.26  ? 93   TRP B CE2   1 ? 
ATOM   4834 C CE3   . TRP B 1 114 ? -38.058 25.396  13.580 1.00 25.15  ? 93   TRP B CE3   1 ? 
ATOM   4835 C CZ2   . TRP B 1 114 ? -35.742 23.829  13.922 1.00 26.66  ? 93   TRP B CZ2   1 ? 
ATOM   4836 C CZ3   . TRP B 1 114 ? -38.131 24.130  14.114 1.00 24.15  ? 93   TRP B CZ3   1 ? 
ATOM   4837 C CH2   . TRP B 1 114 ? -36.993 23.346  14.258 1.00 27.56  ? 93   TRP B CH2   1 ? 
ATOM   4838 N N     . VAL B 1 115 ? -36.046 30.485  14.913 1.00 25.25  ? 94   VAL B N     1 ? 
ATOM   4839 C CA    . VAL B 1 115 ? -34.990 31.384  15.338 1.00 24.01  ? 94   VAL B CA    1 ? 
ATOM   4840 C C     . VAL B 1 115 ? -34.330 30.708  16.527 1.00 23.68  ? 94   VAL B C     1 ? 
ATOM   4841 O O     . VAL B 1 115 ? -34.747 30.871  17.688 1.00 24.73  ? 94   VAL B O     1 ? 
ATOM   4842 C CB    . VAL B 1 115 ? -35.538 32.788  15.665 1.00 26.20  ? 94   VAL B CB    1 ? 
ATOM   4843 C CG1   . VAL B 1 115 ? -34.444 33.751  16.096 1.00 26.32  ? 94   VAL B CG1   1 ? 
ATOM   4844 C CG2   . VAL B 1 115 ? -36.325 33.374  14.494 1.00 26.30  ? 94   VAL B CG2   1 ? 
ATOM   4845 N N     . ARG B 1 116 ? -33.310 29.906  16.223 1.00 24.59  ? 95   ARG B N     1 ? 
ATOM   4846 C CA    . ARG B 1 116 ? -32.916 28.840  17.129 1.00 28.38  ? 95   ARG B CA    1 ? 
ATOM   4847 C C     . ARG B 1 116 ? -32.003 29.317  18.254 1.00 26.32  ? 95   ARG B C     1 ? 
ATOM   4848 O O     . ARG B 1 116 ? -31.842 28.603  19.238 1.00 27.88  ? 95   ARG B O     1 ? 
ATOM   4849 C CB    . ARG B 1 116 ? -32.264 27.700  16.338 1.00 28.05  ? 95   ARG B CB    1 ? 
ATOM   4850 C CG    . ARG B 1 116 ? -30.875 28.014  15.810 1.00 29.46  ? 95   ARG B CG    1 ? 
ATOM   4851 C CD    . ARG B 1 116 ? -30.464 27.008  14.760 1.00 31.88  ? 95   ARG B CD    1 ? 
ATOM   4852 N NE    . ARG B 1 116 ? -29.031 27.097  14.464 1.00 33.39  ? 95   ARG B NE    1 ? 
ATOM   4853 C CZ    . ARG B 1 116 ? -28.460 26.411  13.494 1.00 31.00  ? 95   ARG B CZ    1 ? 
ATOM   4854 N NH1   . ARG B 1 116 ? -29.187 25.620  12.729 1.00 27.06  ? 95   ARG B NH1   1 ? 
ATOM   4855 N NH2   . ARG B 1 116 ? -27.160 26.496  13.325 1.00 32.62  ? 95   ARG B NH2   1 ? 
ATOM   4856 N N     . GLY B 1 117 ? -31.416 30.514  18.126 1.00 26.76  ? 96   GLY B N     1 ? 
ATOM   4857 C CA    . GLY B 1 117 ? -30.483 30.991  19.135 1.00 30.03  ? 96   GLY B CA    1 ? 
ATOM   4858 C C     . GLY B 1 117 ? -29.038 30.795  18.674 1.00 34.34  ? 96   GLY B C     1 ? 
ATOM   4859 O O     . GLY B 1 117 ? -28.809 30.640  17.469 1.00 34.38  ? 96   GLY B O     1 ? 
ATOM   4860 N N     . THR B 1 118 ? -28.109 30.777  19.644 1.00 32.75  ? 97   THR B N     1 ? 
ATOM   4861 C CA    . THR B 1 118 ? -26.678 30.909  19.393 1.00 37.04  ? 97   THR B CA    1 ? 
ATOM   4862 C C     . THR B 1 118 ? -25.903 29.794  20.100 1.00 38.97  ? 97   THR B C     1 ? 
ATOM   4863 O O     . THR B 1 118 ? -26.419 29.079  20.977 1.00 30.91  ? 97   THR B O     1 ? 
ATOM   4864 C CB    . THR B 1 118 ? -26.162 32.266  19.885 1.00 34.34  ? 97   THR B CB    1 ? 
ATOM   4865 O OG1   . THR B 1 118 ? -26.198 32.225  21.301 1.00 34.25  ? 97   THR B OG1   1 ? 
ATOM   4866 C CG2   . THR B 1 118 ? -27.003 33.463  19.495 1.00 35.37  ? 97   THR B CG2   1 ? 
ATOM   4867 N N     . LYS B 1 119 ? -24.614 29.709  19.745 1.00 37.77  ? 98   LYS B N     1 ? 
ATOM   4868 C CA    . LYS B 1 119 ? -23.677 28.780  20.362 1.00 38.58  ? 98   LYS B CA    1 ? 
ATOM   4869 C C     . LYS B 1 119 ? -23.704 28.872  21.885 1.00 35.57  ? 98   LYS B C     1 ? 
ATOM   4870 O O     . LYS B 1 119 ? -23.732 27.839  22.560 1.00 37.66  ? 98   LYS B O     1 ? 
ATOM   4871 C CB    . LYS B 1 119 ? -22.252 29.027  19.843 1.00 40.01  ? 98   LYS B CB    1 ? 
ATOM   4872 C CG    . LYS B 1 119 ? -21.140 28.314  20.625 1.00 40.17  ? 98   LYS B CG    1 ? 
ATOM   4873 C CD    . LYS B 1 119 ? -19.780 28.280  19.910 1.00 40.34  ? 98   LYS B CD    1 ? 
ATOM   4874 C CE    . LYS B 1 119 ? -18.655 27.915  20.825 1.00 38.59  ? 98   LYS B CE    1 ? 
ATOM   4875 N NZ    . LYS B 1 119 ? -18.757 26.505  21.211 1.00 43.14  ? 98   LYS B NZ    1 ? 
ATOM   4876 N N     . GLU B 1 120 ? -23.642 30.093  22.423 1.00 33.00  ? 99   GLU B N     1 ? 
ATOM   4877 C CA    . GLU B 1 120 ? -23.622 30.262  23.867 1.00 44.43  ? 99   GLU B CA    1 ? 
ATOM   4878 C C     . GLU B 1 120 ? -24.887 29.690  24.506 1.00 37.48  ? 99   GLU B C     1 ? 
ATOM   4879 O O     . GLU B 1 120 ? -24.823 29.182  25.622 1.00 34.09  ? 99   GLU B O     1 ? 
ATOM   4880 C CB    . GLU B 1 120 ? -23.516 31.710  24.349 1.00 47.01  ? 99   GLU B CB    1 ? 
ATOM   4881 C CG    . GLU B 1 120 ? -22.265 32.414  23.841 1.00 56.36  ? 99   GLU B CG    1 ? 
ATOM   4882 C CD    . GLU B 1 120 ? -22.471 33.177  22.546 1.00 61.12  ? 99   GLU B CD    1 ? 
ATOM   4883 O OE1   . GLU B 1 120 ? -22.633 32.577  21.448 1.00 61.06  ? 99   GLU B OE1   1 ? 
ATOM   4884 O OE2   . GLU B 1 120 ? -22.446 34.420  22.683 1.00 63.99  ? 99   GLU B OE2   1 ? 
ATOM   4885 N N     . ASP B 1 121 ? -26.033 29.820  23.825 1.00 32.41  ? 100  ASP B N     1 ? 
ATOM   4886 C CA    . ASP B 1 121 ? -27.285 29.276  24.349 1.00 33.27  ? 100  ASP B CA    1 ? 
ATOM   4887 C C     . ASP B 1 121 ? -27.140 27.776  24.598 1.00 29.40  ? 100  ASP B C     1 ? 
ATOM   4888 O O     . ASP B 1 121 ? -27.371 27.293  25.711 1.00 28.51  ? 100  ASP B O     1 ? 
ATOM   4889 C CB    . ASP B 1 121 ? -28.453 29.546  23.418 1.00 29.52  ? 100  ASP B CB    1 ? 
ATOM   4890 C CG    . ASP B 1 121 ? -28.858 31.003  23.264 1.00 29.06  ? 100  ASP B CG    1 ? 
ATOM   4891 O OD1   . ASP B 1 121 ? -28.691 31.772  24.236 1.00 33.55  ? 100  ASP B OD1   1 ? 
ATOM   4892 O OD2   . ASP B 1 121 ? -29.421 31.330  22.213 1.00 28.28  ? 100  ASP B OD2   1 ? 
ATOM   4893 N N     . TYR B 1 122 ? -26.732 27.042  23.558 1.00 29.14  ? 101  TYR B N     1 ? 
ATOM   4894 C CA    . TYR B 1 122 ? -26.692 25.588  23.640 1.00 32.77  ? 101  TYR B CA    1 ? 
ATOM   4895 C C     . TYR B 1 122 ? -25.595 25.150  24.609 1.00 32.61  ? 101  TYR B C     1 ? 
ATOM   4896 O O     . TYR B 1 122 ? -25.831 24.263  25.426 1.00 31.45  ? 101  TYR B O     1 ? 
ATOM   4897 C CB    . TYR B 1 122 ? -26.642 24.999  22.227 1.00 30.45  ? 101  TYR B CB    1 ? 
ATOM   4898 C CG    . TYR B 1 122 ? -27.968 25.241  21.520 1.00 28.28  ? 101  TYR B CG    1 ? 
ATOM   4899 C CD1   . TYR B 1 122 ? -29.063 24.400  21.721 1.00 28.39  ? 101  TYR B CD1   1 ? 
ATOM   4900 C CD2   . TYR B 1 122 ? -28.151 26.335  20.696 1.00 27.16  ? 101  TYR B CD2   1 ? 
ATOM   4901 C CE1   . TYR B 1 122 ? -30.270 24.624  21.068 1.00 25.83  ? 101  TYR B CE1   1 ? 
ATOM   4902 C CE2   . TYR B 1 122 ? -29.359 26.588  20.063 1.00 27.68  ? 101  TYR B CE2   1 ? 
ATOM   4903 C CZ    . TYR B 1 122 ? -30.427 25.726  20.253 1.00 24.56  ? 101  TYR B CZ    1 ? 
ATOM   4904 O OH    . TYR B 1 122 ? -31.610 25.996  19.620 1.00 25.88  ? 101  TYR B OH    1 ? 
ATOM   4905 N N     . ASP B 1 123 ? -24.438 25.820  24.560 1.00 33.17  ? 102  ASP B N     1 ? 
ATOM   4906 C CA    . ASP B 1 123 ? -23.335 25.517  25.461 1.00 33.99  ? 102  ASP B CA    1 ? 
ATOM   4907 C C     . ASP B 1 123 ? -23.708 25.752  26.921 1.00 33.96  ? 102  ASP B C     1 ? 
ATOM   4908 O O     . ASP B 1 123 ? -23.236 25.011  27.791 1.00 37.02  ? 102  ASP B O     1 ? 
ATOM   4909 C CB    . ASP B 1 123 ? -22.093 26.313  25.087 1.00 36.23  ? 102  ASP B CB    1 ? 
ATOM   4910 C CG    . ASP B 1 123 ? -21.328 25.771  23.889 1.00 37.11  ? 102  ASP B CG    1 ? 
ATOM   4911 O OD1   . ASP B 1 123 ? -21.593 24.617  23.489 1.00 39.39  ? 102  ASP B OD1   1 ? 
ATOM   4912 O OD2   . ASP B 1 123 ? -20.512 26.526  23.340 1.00 37.68  ? 102  ASP B OD2   1 ? 
ATOM   4913 N N     . SER B 1 124 ? -24.549 26.762  27.197 1.00 30.97  ? 103  SER B N     1 ? 
ATOM   4914 C CA    . SER B 1 124 ? -24.899 27.080  28.573 1.00 30.56  ? 103  SER B CA    1 ? 
ATOM   4915 C C     . SER B 1 124 ? -25.586 25.919  29.292 1.00 31.64  ? 103  SER B C     1 ? 
ATOM   4916 O O     . SER B 1 124 ? -25.546 25.865  30.523 1.00 28.62  ? 103  SER B O     1 ? 
ATOM   4917 C CB    . SER B 1 124 ? -25.772 28.310  28.671 1.00 33.42  ? 103  SER B CB    1 ? 
ATOM   4918 O OG    . SER B 1 124 ? -27.078 28.099  28.138 1.00 29.56  ? 103  SER B OG    1 ? 
ATOM   4919 N N     . TRP B 1 125 ? -26.285 25.031  28.568 1.00 28.44  ? 104  TRP B N     1 ? 
ATOM   4920 C CA    . TRP B 1 125 ? -27.032 23.982  29.250 1.00 29.04  ? 104  TRP B CA    1 ? 
ATOM   4921 C C     . TRP B 1 125 ? -26.033 23.044  29.921 1.00 27.70  ? 104  TRP B C     1 ? 
ATOM   4922 O O     . TRP B 1 125 ? -26.225 22.616  31.053 1.00 27.95  ? 104  TRP B O     1 ? 
ATOM   4923 C CB    . TRP B 1 125 ? -27.954 23.187  28.314 1.00 28.80  ? 104  TRP B CB    1 ? 
ATOM   4924 C CG    . TRP B 1 125 ? -29.026 23.986  27.604 1.00 28.74  ? 104  TRP B CG    1 ? 
ATOM   4925 C CD1   . TRP B 1 125 ? -29.159 25.342  27.494 1.00 28.89  ? 104  TRP B CD1   1 ? 
ATOM   4926 C CD2   . TRP B 1 125 ? -30.101 23.417  26.829 1.00 26.31  ? 104  TRP B CD2   1 ? 
ATOM   4927 N NE1   . TRP B 1 125 ? -30.233 25.654  26.703 1.00 30.86  ? 104  TRP B NE1   1 ? 
ATOM   4928 C CE2   . TRP B 1 125 ? -30.825 24.492  26.274 1.00 27.88  ? 104  TRP B CE2   1 ? 
ATOM   4929 C CE3   . TRP B 1 125 ? -30.497 22.109  26.523 1.00 28.90  ? 104  TRP B CE3   1 ? 
ATOM   4930 C CZ2   . TRP B 1 125 ? -31.937 24.289  25.458 1.00 26.80  ? 104  TRP B CZ2   1 ? 
ATOM   4931 C CZ3   . TRP B 1 125 ? -31.573 21.912  25.684 1.00 26.17  ? 104  TRP B CZ3   1 ? 
ATOM   4932 C CH2   . TRP B 1 125 ? -32.296 22.988  25.180 1.00 27.26  ? 104  TRP B CH2   1 ? 
ATOM   4933 N N     . GLU B 1 126 ? -24.938 22.761  29.227 1.00 28.01  ? 105  GLU B N     1 ? 
ATOM   4934 C CA    . GLU B 1 126 ? -23.903 21.905  29.785 1.00 30.54  ? 105  GLU B CA    1 ? 
ATOM   4935 C C     . GLU B 1 126 ? -23.206 22.628  30.933 1.00 29.93  ? 105  GLU B C     1 ? 
ATOM   4936 O O     . GLU B 1 126 ? -22.972 22.039  31.972 1.00 29.70  ? 105  GLU B O     1 ? 
ATOM   4937 C CB    . GLU B 1 126 ? -22.909 21.480  28.705 1.00 33.63  ? 105  GLU B CB    1 ? 
ATOM   4938 C CG    . GLU B 1 126 ? -21.793 20.591  29.244 1.00 40.49  ? 105  GLU B CG    1 ? 
ATOM   4939 C CD    . GLU B 1 126 ? -21.087 19.921  28.099 1.00 43.03  ? 105  GLU B CD    1 ? 
ATOM   4940 O OE1   . GLU B 1 126 ? -21.391 18.760  27.871 1.00 50.34  ? 105  GLU B OE1   1 ? 
ATOM   4941 O OE2   . GLU B 1 126 ? -20.288 20.570  27.407 1.00 53.47  ? 105  GLU B OE2   1 ? 
ATOM   4942 N N     . ALA B 1 127 ? -22.936 23.920  30.758 1.00 31.33  ? 106  ALA B N     1 ? 
ATOM   4943 C CA    . ALA B 1 127 ? -22.261 24.697  31.786 1.00 33.35  ? 106  ALA B CA    1 ? 
ATOM   4944 C C     . ALA B 1 127 ? -23.057 24.700  33.089 1.00 35.76  ? 106  ALA B C     1 ? 
ATOM   4945 O O     . ALA B 1 127 ? -22.492 24.784  34.171 1.00 36.34  ? 106  ALA B O     1 ? 
ATOM   4946 C CB    . ALA B 1 127 ? -22.011 26.091  31.261 1.00 32.27  ? 106  ALA B CB    1 ? 
ATOM   4947 N N     . GLN B 1 128 ? -24.386 24.579  32.984 1.00 37.72  ? 107  GLN B N     1 ? 
ATOM   4948 C CA    . GLN B 1 128 ? -25.324 24.615  34.100 1.00 33.93  ? 107  GLN B CA    1 ? 
ATOM   4949 C C     . GLN B 1 128 ? -25.572 23.204  34.661 1.00 35.65  ? 107  GLN B C     1 ? 
ATOM   4950 O O     . GLN B 1 128 ? -26.417 23.008  35.527 1.00 31.72  ? 107  GLN B O     1 ? 
ATOM   4951 C CB    . GLN B 1 128 ? -26.447 25.315  33.308 1.00 41.38  ? 107  GLN B CB    1 ? 
ATOM   4952 C CG    . GLN B 1 128 ? -27.804 25.501  33.966 1.00 43.41  ? 107  GLN B CG    1 ? 
ATOM   4953 C CD    . GLN B 1 128 ? -28.686 24.269  34.049 1.00 36.88  ? 107  GLN B CD    1 ? 
ATOM   4954 O OE1   . GLN B 1 128 ? -29.489 24.180  34.975 1.00 34.72  ? 107  GLN B OE1   1 ? 
ATOM   4955 N NE2   . GLN B 1 128 ? -28.547 23.284  33.163 1.00 40.10  ? 107  GLN B NE2   1 ? 
ATOM   4956 N N     . GLY B 1 129 ? -24.892 22.174  34.133 1.00 33.47  ? 108  GLY B N     1 ? 
ATOM   4957 C CA    . GLY B 1 129 ? -24.909 20.850  34.739 1.00 34.22  ? 108  GLY B CA    1 ? 
ATOM   4958 C C     . GLY B 1 129 ? -25.539 19.761  33.869 1.00 31.84  ? 108  GLY B C     1 ? 
ATOM   4959 O O     . GLY B 1 129 ? -25.746 18.666  34.342 1.00 33.68  ? 108  GLY B O     1 ? 
ATOM   4960 N N     . ALA B 1 130 ? -25.833 20.052  32.600 1.00 32.70  ? 109  ALA B N     1 ? 
ATOM   4961 C CA    . ALA B 1 130 ? -26.420 19.067  31.706 1.00 33.55  ? 109  ALA B CA    1 ? 
ATOM   4962 C C     . ALA B 1 130 ? -25.366 18.524  30.749 1.00 32.99  ? 109  ALA B C     1 ? 
ATOM   4963 O O     . ALA B 1 130 ? -25.238 18.984  29.612 1.00 29.50  ? 109  ALA B O     1 ? 
ATOM   4964 C CB    . ALA B 1 130 ? -27.573 19.693  30.937 1.00 30.97  ? 109  ALA B CB    1 ? 
ATOM   4965 N N     . LYS B 1 131 ? -24.605 17.535  31.215 1.00 41.92  ? 110  LYS B N     1 ? 
ATOM   4966 C CA    . LYS B 1 131 ? -23.483 17.017  30.436 1.00 39.86  ? 110  LYS B CA    1 ? 
ATOM   4967 C C     . LYS B 1 131 ? -23.999 16.450  29.113 1.00 33.11  ? 110  LYS B C     1 ? 
ATOM   4968 O O     . LYS B 1 131 ? -24.924 15.652  29.091 1.00 33.25  ? 110  LYS B O     1 ? 
ATOM   4969 C CB    . LYS B 1 131 ? -22.738 15.902  31.190 1.00 43.97  ? 110  LYS B CB    1 ? 
ATOM   4970 C CG    . LYS B 1 131 ? -22.235 16.211  32.587 1.00 52.90  ? 110  LYS B CG    1 ? 
ATOM   4971 C CD    . LYS B 1 131 ? -21.782 14.991  33.391 1.00 61.88  ? 110  LYS B CD    1 ? 
ATOM   4972 C CE    . LYS B 1 131 ? -21.716 15.320  34.863 1.00 70.16  ? 110  LYS B CE    1 ? 
ATOM   4973 N NZ    . LYS B 1 131 ? -20.611 14.636  35.544 1.00 69.64  ? 110  LYS B NZ    1 ? 
ATOM   4974 N N     . GLY B 1 132 ? -23.393 16.855  28.004 1.00 30.54  ? 111  GLY B N     1 ? 
ATOM   4975 C CA    . GLY B 1 132 ? -23.722 16.273  26.712 1.00 31.01  ? 111  GLY B CA    1 ? 
ATOM   4976 C C     . GLY B 1 132 ? -24.639 17.162  25.881 1.00 32.33  ? 111  GLY B C     1 ? 
ATOM   4977 O O     . GLY B 1 132 ? -24.881 16.854  24.720 1.00 33.90  ? 111  GLY B O     1 ? 
ATOM   4978 N N     . TRP B 1 133 ? -25.150 18.246  26.496 1.00 32.87  ? 112  TRP B N     1 ? 
ATOM   4979 C CA    . TRP B 1 133 ? -26.061 19.175  25.840 1.00 30.38  ? 112  TRP B CA    1 ? 
ATOM   4980 C C     . TRP B 1 133 ? -25.307 20.467  25.554 1.00 27.43  ? 112  TRP B C     1 ? 
ATOM   4981 O O     . TRP B 1 133 ? -25.200 21.314  26.443 1.00 30.42  ? 112  TRP B O     1 ? 
ATOM   4982 C CB    . TRP B 1 133 ? -27.274 19.440  26.753 1.00 29.73  ? 112  TRP B CB    1 ? 
ATOM   4983 C CG    . TRP B 1 133 ? -28.168 18.249  26.983 1.00 28.23  ? 112  TRP B CG    1 ? 
ATOM   4984 C CD1   . TRP B 1 133 ? -27.959 17.212  27.832 1.00 29.82  ? 112  TRP B CD1   1 ? 
ATOM   4985 C CD2   . TRP B 1 133 ? -29.459 18.015  26.392 1.00 29.35  ? 112  TRP B CD2   1 ? 
ATOM   4986 N NE1   . TRP B 1 133 ? -29.007 16.334  27.803 1.00 29.74  ? 112  TRP B NE1   1 ? 
ATOM   4987 C CE2   . TRP B 1 133 ? -29.945 16.801  26.924 1.00 29.81  ? 112  TRP B CE2   1 ? 
ATOM   4988 C CE3   . TRP B 1 133 ? -30.239 18.707  25.463 1.00 28.67  ? 112  TRP B CE3   1 ? 
ATOM   4989 C CZ2   . TRP B 1 133 ? -31.179 16.271  26.552 1.00 29.52  ? 112  TRP B CZ2   1 ? 
ATOM   4990 C CZ3   . TRP B 1 133 ? -31.453 18.183  25.096 1.00 27.76  ? 112  TRP B CZ3   1 ? 
ATOM   4991 C CH2   . TRP B 1 133 ? -31.925 16.992  25.647 1.00 30.18  ? 112  TRP B CH2   1 ? 
ATOM   4992 N N     . ASN B 1 134 ? -24.858 20.634  24.301 1.00 31.10  ? 113  ASN B N     1 ? 
ATOM   4993 C CA    . ASN B 1 134 ? -23.946 21.706  23.923 1.00 31.08  ? 113  ASN B CA    1 ? 
ATOM   4994 C C     . ASN B 1 134 ? -24.173 22.025  22.454 1.00 31.85  ? 113  ASN B C     1 ? 
ATOM   4995 O O     . ASN B 1 134 ? -24.984 21.371  21.781 1.00 33.24  ? 113  ASN B O     1 ? 
ATOM   4996 C CB    . ASN B 1 134 ? -22.492 21.339  24.219 1.00 34.55  ? 113  ASN B CB    1 ? 
ATOM   4997 C CG    . ASN B 1 134 ? -22.109 20.010  23.595 1.00 33.72  ? 113  ASN B CG    1 ? 
ATOM   4998 O OD1   . ASN B 1 134 ? -22.286 19.806  22.382 1.00 34.45  ? 113  ASN B OD1   1 ? 
ATOM   4999 N ND2   . ASN B 1 134 ? -21.679 19.068  24.418 1.00 36.44  ? 113  ASN B ND2   1 ? 
ATOM   5000 N N     . PHE B 1 135 ? -23.470 23.047  21.959 1.00 29.86  ? 114  PHE B N     1 ? 
ATOM   5001 C CA    . PHE B 1 135 ? -23.713 23.525  20.604 1.00 34.29  ? 114  PHE B CA    1 ? 
ATOM   5002 C C     . PHE B 1 135 ? -23.331 22.473  19.558 1.00 33.30  ? 114  PHE B C     1 ? 
ATOM   5003 O O     . PHE B 1 135 ? -23.920 22.399  18.487 1.00 32.54  ? 114  PHE B O     1 ? 
ATOM   5004 C CB    . PHE B 1 135 ? -22.928 24.802  20.315 1.00 35.10  ? 114  PHE B CB    1 ? 
ATOM   5005 C CG    . PHE B 1 135 ? -23.347 25.488  19.028 1.00 36.16  ? 114  PHE B CG    1 ? 
ATOM   5006 C CD1   . PHE B 1 135 ? -24.687 25.778  18.771 1.00 35.70  ? 114  PHE B CD1   1 ? 
ATOM   5007 C CD2   . PHE B 1 135 ? -22.401 25.828  18.067 1.00 40.75  ? 114  PHE B CD2   1 ? 
ATOM   5008 C CE1   . PHE B 1 135 ? -25.058 26.427  17.602 1.00 40.85  ? 114  PHE B CE1   1 ? 
ATOM   5009 C CE2   . PHE B 1 135 ? -22.776 26.472  16.892 1.00 40.55  ? 114  PHE B CE2   1 ? 
ATOM   5010 C CZ    . PHE B 1 135 ? -24.104 26.775  16.666 1.00 42.28  ? 114  PHE B CZ    1 ? 
ATOM   5011 N N     . SER B 1 136 ? -22.299 21.691  19.844 1.00 31.14  ? 115  SER B N     1 ? 
ATOM   5012 C CA    . SER B 1 136 ? -21.852 20.679  18.908 1.00 37.17  ? 115  SER B CA    1 ? 
ATOM   5013 C C     . SER B 1 136 ? -22.952 19.632  18.673 1.00 36.09  ? 115  SER B C     1 ? 
ATOM   5014 O O     . SER B 1 136 ? -23.248 19.259  17.545 1.00 34.84  ? 115  SER B O     1 ? 
ATOM   5015 C CB    . SER B 1 136 ? -20.559 20.050  19.420 1.00 40.74  ? 115  SER B CB    1 ? 
ATOM   5016 O OG    . SER B 1 136 ? -20.094 19.070  18.508 1.00 43.04  ? 115  SER B OG    1 ? 
ATOM   5017 N N     . LYS B 1 137 ? -23.590 19.187  19.749 1.00 34.38  ? 116  LYS B N     1 ? 
ATOM   5018 C CA    . LYS B 1 137 ? -24.729 18.289  19.640 1.00 34.78  ? 116  LYS B CA    1 ? 
ATOM   5019 C C     . LYS B 1 137 ? -25.893 18.996  18.930 1.00 31.79  ? 116  LYS B C     1 ? 
ATOM   5020 O O     . LYS B 1 137 ? -26.566 18.408  18.079 1.00 30.53  ? 116  LYS B O     1 ? 
ATOM   5021 C CB    . LYS B 1 137 ? -25.009 17.783  21.056 1.00 37.51  ? 116  LYS B CB    1 ? 
ATOM   5022 C CG    . LYS B 1 137 ? -25.310 16.311  21.133 1.00 47.26  ? 116  LYS B CG    1 ? 
ATOM   5023 C CD    . LYS B 1 137 ? -24.087 15.419  20.970 1.00 48.52  ? 116  LYS B CD    1 ? 
ATOM   5024 C CE    . LYS B 1 137 ? -24.243 14.376  19.893 1.00 56.88  ? 116  LYS B CE    1 ? 
ATOM   5025 N NZ    . LYS B 1 137 ? -25.274 13.350  20.061 1.00 52.35  ? 116  LYS B NZ    1 ? 
ATOM   5026 N N     . ALA B 1 138 ? -26.123 20.283  19.236 1.00 30.64  ? 117  ALA B N     1 ? 
ATOM   5027 C CA    . ALA B 1 138 ? -27.194 21.015  18.586 1.00 28.38  ? 117  ALA B CA    1 ? 
ATOM   5028 C C     . ALA B 1 138 ? -27.018 21.023  17.061 1.00 28.98  ? 117  ALA B C     1 ? 
ATOM   5029 O O     . ALA B 1 138 ? -27.959 20.778  16.307 1.00 29.14  ? 117  ALA B O     1 ? 
ATOM   5030 C CB    . ALA B 1 138 ? -27.280 22.413  19.155 1.00 29.29  ? 117  ALA B CB    1 ? 
ATOM   5031 N N     . LEU B 1 139 ? -25.812 21.363  16.596 1.00 31.53  ? 118  LEU B N     1 ? 
ATOM   5032 C CA    . LEU B 1 139 ? -25.508 21.370  15.171 1.00 31.60  ? 118  LEU B CA    1 ? 
ATOM   5033 C C     . LEU B 1 139 ? -25.800 20.019  14.534 1.00 30.21  ? 118  LEU B C     1 ? 
ATOM   5034 O O     . LEU B 1 139 ? -26.371 19.966  13.443 1.00 29.41  ? 118  LEU B O     1 ? 
ATOM   5035 C CB    . LEU B 1 139 ? -24.054 21.788  14.962 1.00 36.78  ? 118  LEU B CB    1 ? 
ATOM   5036 C CG    . LEU B 1 139 ? -23.794 23.195  14.414 1.00 40.16  ? 118  LEU B CG    1 ? 
ATOM   5037 C CD1   . LEU B 1 139 ? -24.873 24.222  14.626 1.00 41.13  ? 118  LEU B CD1   1 ? 
ATOM   5038 C CD2   . LEU B 1 139 ? -22.473 23.681  14.991 1.00 43.64  ? 118  LEU B CD2   1 ? 
ATOM   5039 N N     . GLU B 1 140 ? -25.380 18.929  15.196 1.00 32.56  ? 119  GLU B N     1 ? 
ATOM   5040 C CA    . GLU B 1 140 ? -25.649 17.576  14.723 1.00 34.09  ? 119  GLU B CA    1 ? 
ATOM   5041 C C     . GLU B 1 140 ? -27.153 17.350  14.563 1.00 34.06  ? 119  GLU B C     1 ? 
ATOM   5042 O O     . GLU B 1 140 ? -27.611 16.885  13.525 1.00 30.83  ? 119  GLU B O     1 ? 
ATOM   5043 C CB    . GLU B 1 140 ? -25.027 16.596  15.715 1.00 41.48  ? 119  GLU B CB    1 ? 
ATOM   5044 C CG    . GLU B 1 140 ? -25.083 15.130  15.310 1.00 51.63  ? 119  GLU B CG    1 ? 
ATOM   5045 C CD    . GLU B 1 140 ? -24.625 14.299  16.504 1.00 52.60  ? 119  GLU B CD    1 ? 
ATOM   5046 O OE1   . GLU B 1 140 ? -23.619 14.675  17.134 1.00 51.86  ? 119  GLU B OE1   1 ? 
ATOM   5047 O OE2   . GLU B 1 140 ? -25.295 13.297  16.812 1.00 61.77  ? 119  GLU B OE2   1 ? 
ATOM   5048 N N     . MET B 1 141 ? -27.938 17.750  15.567 1.00 31.65  ? 120  MET B N     1 ? 
ATOM   5049 C CA    . MET B 1 141 ? -29.383 17.579  15.506 1.00 32.31  ? 120  MET B CA    1 ? 
ATOM   5050 C C     . MET B 1 141 ? -30.004 18.480  14.439 1.00 28.53  ? 120  MET B C     1 ? 
ATOM   5051 O O     . MET B 1 141 ? -30.934 18.057  13.766 1.00 28.77  ? 120  MET B O     1 ? 
ATOM   5052 C CB    . MET B 1 141 ? -30.017 17.797  16.887 1.00 29.68  ? 120  MET B CB    1 ? 
ATOM   5053 C CG    . MET B 1 141 ? -29.483 16.840  17.930 1.00 31.38  ? 120  MET B CG    1 ? 
ATOM   5054 S SD    . MET B 1 141 ? -29.761 15.118  17.475 1.00 36.16  ? 120  MET B SD    1 ? 
ATOM   5055 C CE    . MET B 1 141 ? -29.043 14.159  18.808 1.00 39.72  ? 120  MET B CE    1 ? 
ATOM   5056 N N     . PHE B 1 142 ? -29.507 19.708  14.253 1.00 30.10  ? 121  PHE B N     1 ? 
ATOM   5057 C CA    . PHE B 1 142 ? -30.138 20.606  13.296 1.00 29.34  ? 121  PHE B CA    1 ? 
ATOM   5058 C C     . PHE B 1 142 ? -29.925 20.124  11.857 1.00 31.55  ? 121  PHE B C     1 ? 
ATOM   5059 O O     . PHE B 1 142 ? -30.650 20.550  10.964 1.00 31.94  ? 121  PHE B O     1 ? 
ATOM   5060 C CB    . PHE B 1 142 ? -29.671 22.045  13.536 1.00 30.40  ? 121  PHE B CB    1 ? 
ATOM   5061 C CG    . PHE B 1 142 ? -30.321 22.694  14.753 1.00 30.11  ? 121  PHE B CG    1 ? 
ATOM   5062 C CD1   . PHE B 1 142 ? -31.693 22.610  14.958 1.00 31.89  ? 121  PHE B CD1   1 ? 
ATOM   5063 C CD2   . PHE B 1 142 ? -29.549 23.369  15.699 1.00 33.43  ? 121  PHE B CD2   1 ? 
ATOM   5064 C CE1   . PHE B 1 142 ? -32.281 23.172  16.086 1.00 30.22  ? 121  PHE B CE1   1 ? 
ATOM   5065 C CE2   . PHE B 1 142 ? -30.135 23.924  16.825 1.00 33.56  ? 121  PHE B CE2   1 ? 
ATOM   5066 C CZ    . PHE B 1 142 ? -31.499 23.815  17.019 1.00 31.20  ? 121  PHE B CZ    1 ? 
ATOM   5067 N N     . GLN B 1 143 ? -28.941 19.243  11.624 1.00 33.02  ? 122  GLN B N     1 ? 
ATOM   5068 C CA    . GLN B 1 143 ? -28.778 18.623  10.315 1.00 34.84  ? 122  GLN B CA    1 ? 
ATOM   5069 C C     . GLN B 1 143 ? -29.973 17.719  10.042 1.00 33.42  ? 122  GLN B C     1 ? 
ATOM   5070 O O     . GLN B 1 143 ? -30.504 17.710  8.929  1.00 38.74  ? 122  GLN B O     1 ? 
ATOM   5071 C CB    . GLN B 1 143 ? -27.486 17.796  10.237 1.00 34.17  ? 122  GLN B CB    1 ? 
ATOM   5072 C CG    . GLN B 1 143 ? -26.213 18.638  10.183 1.00 36.31  ? 122  GLN B CG    1 ? 
ATOM   5073 C CD    . GLN B 1 143 ? -26.098 19.365  8.857  1.00 38.77  ? 122  GLN B CD    1 ? 
ATOM   5074 O OE1   . GLN B 1 143 ? -26.316 18.774  7.794  1.00 39.50  ? 122  GLN B OE1   1 ? 
ATOM   5075 N NE2   . GLN B 1 143 ? -25.845 20.664  8.897  1.00 38.21  ? 122  GLN B NE2   1 ? 
ATOM   5076 N N     . LYS B 1 144 ? -30.391 16.980  11.082 1.00 32.76  ? 123  LYS B N     1 ? 
ATOM   5077 C CA    . LYS B 1 144 ? -31.530 16.073  11.007 1.00 34.38  ? 123  LYS B CA    1 ? 
ATOM   5078 C C     . LYS B 1 144 ? -32.869 16.813  10.985 1.00 32.98  ? 123  LYS B C     1 ? 
ATOM   5079 O O     . LYS B 1 144 ? -33.834 16.294  10.428 1.00 30.19  ? 123  LYS B O     1 ? 
ATOM   5080 C CB    . LYS B 1 144 ? -31.656 15.156  12.226 1.00 35.52  ? 123  LYS B CB    1 ? 
ATOM   5081 C CG    . LYS B 1 144 ? -30.520 14.202  12.452 1.00 39.77  ? 123  LYS B CG    1 ? 
ATOM   5082 C CD    . LYS B 1 144 ? -30.509 13.523  13.816 1.00 42.54  ? 123  LYS B CD    1 ? 
ATOM   5083 C CE    . LYS B 1 144 ? -31.270 12.241  13.900 1.00 46.07  ? 123  LYS B CE    1 ? 
ATOM   5084 N NZ    . LYS B 1 144 ? -30.910 11.563  15.151 1.00 48.48  ? 123  LYS B NZ    1 ? 
ATOM   5085 N N     . ILE B 1 145 ? -32.939 17.978  11.651 1.00 30.85  ? 124  ILE B N     1 ? 
ATOM   5086 C CA    . ILE B 1 145 ? -34.184 18.711  11.832 1.00 26.40  ? 124  ILE B CA    1 ? 
ATOM   5087 C C     . ILE B 1 145 ? -34.479 19.629  10.650 1.00 26.28  ? 124  ILE B C     1 ? 
ATOM   5088 O O     . ILE B 1 145 ? -35.598 19.646  10.165 1.00 24.60  ? 124  ILE B O     1 ? 
ATOM   5089 C CB    . ILE B 1 145 ? -34.162 19.524  13.138 1.00 26.92  ? 124  ILE B CB    1 ? 
ATOM   5090 C CG1   . ILE B 1 145 ? -34.085 18.619  14.353 1.00 27.59  ? 124  ILE B CG1   1 ? 
ATOM   5091 C CG2   . ILE B 1 145 ? -35.389 20.442  13.212 1.00 27.35  ? 124  ILE B CG2   1 ? 
ATOM   5092 C CD1   . ILE B 1 145 ? -33.606 19.293  15.636 1.00 31.18  ? 124  ILE B CD1   1 ? 
ATOM   5093 N N     . GLU B 1 146 ? -33.514 20.474  10.276 1.00 26.38  ? 125  GLU B N     1 ? 
ATOM   5094 C CA    . GLU B 1 146 ? -33.757 21.550  9.334  1.00 26.89  ? 125  GLU B CA    1 ? 
ATOM   5095 C C     . GLU B 1 146 ? -33.724 21.088  7.875  1.00 25.04  ? 125  GLU B C     1 ? 
ATOM   5096 O O     . GLU B 1 146 ? -32.907 20.270  7.454  1.00 30.13  ? 125  GLU B O     1 ? 
ATOM   5097 C CB    . GLU B 1 146 ? -32.695 22.627  9.520  1.00 29.45  ? 125  GLU B CB    1 ? 
ATOM   5098 C CG    . GLU B 1 146 ? -32.764 23.294  10.887 1.00 30.48  ? 125  GLU B CG    1 ? 
ATOM   5099 C CD    . GLU B 1 146 ? -31.838 24.493  11.032 1.00 33.87  ? 125  GLU B CD    1 ? 
ATOM   5100 O OE1   . GLU B 1 146 ? -30.908 24.602  10.182 1.00 35.94  ? 125  GLU B OE1   1 ? 
ATOM   5101 O OE2   . GLU B 1 146 ? -32.042 25.329  11.961 1.00 30.25  ? 125  GLU B OE2   1 ? 
ATOM   5102 N N     . GLN B 1 147 ? -34.648 21.647  7.103  1.00 27.04  ? 126  GLN B N     1 ? 
ATOM   5103 C CA    . GLN B 1 147 ? -34.651 21.550  5.656  1.00 29.24  ? 126  GLN B CA    1 ? 
ATOM   5104 C C     . GLN B 1 147 ? -34.786 22.960  5.101  1.00 28.81  ? 126  GLN B C     1 ? 
ATOM   5105 O O     . GLN B 1 147 ? -35.899 23.414  4.811  1.00 30.27  ? 126  GLN B O     1 ? 
ATOM   5106 C CB    . GLN B 1 147 ? -35.770 20.629  5.168  1.00 32.65  ? 126  GLN B CB    1 ? 
ATOM   5107 C CG    . GLN B 1 147 ? -35.933 20.599  3.651  1.00 34.87  ? 126  GLN B CG    1 ? 
ATOM   5108 C CD    . GLN B 1 147 ? -36.949 19.574  3.192  1.00 39.91  ? 126  GLN B CD    1 ? 
ATOM   5109 O OE1   . GLN B 1 147 ? -37.158 18.540  3.833  1.00 45.99  ? 126  GLN B OE1   1 ? 
ATOM   5110 N NE2   . GLN B 1 147 ? -37.633 19.860  2.099  1.00 36.77  ? 126  GLN B NE2   1 ? 
ATOM   5111 N N     . THR B 1 148 ? -33.637 23.640  4.956  1.00 31.57  ? 127  THR B N     1 ? 
ATOM   5112 C CA    . THR B 1 148 ? -33.612 25.025  4.518  1.00 32.60  ? 127  THR B CA    1 ? 
ATOM   5113 C C     . THR B 1 148 ? -32.645 25.181  3.344  1.00 34.98  ? 127  THR B C     1 ? 
ATOM   5114 O O     . THR B 1 148 ? -31.677 24.442  3.241  1.00 31.27  ? 127  THR B O     1 ? 
ATOM   5115 C CB    . THR B 1 148 ? -33.241 25.951  5.676  1.00 31.30  ? 127  THR B CB    1 ? 
ATOM   5116 O OG1   . THR B 1 148 ? -33.131 27.274  5.134  1.00 29.29  ? 127  THR B OG1   1 ? 
ATOM   5117 C CG2   . THR B 1 148 ? -31.976 25.541  6.401  1.00 29.94  ? 127  THR B CG2   1 ? 
ATOM   5118 N N     . ASN B 1 149 ? -32.929 26.174  2.488  1.00 33.59  ? 128  ASN B N     1 ? 
ATOM   5119 C CA    . ASN B 1 149 ? -32.031 26.541  1.405  1.00 38.92  ? 128  ASN B CA    1 ? 
ATOM   5120 C C     . ASN B 1 149 ? -30.850 27.339  1.947  1.00 41.38  ? 128  ASN B C     1 ? 
ATOM   5121 O O     . ASN B 1 149 ? -29.955 27.667  1.180  1.00 45.31  ? 128  ASN B O     1 ? 
ATOM   5122 C CB    . ASN B 1 149 ? -32.737 27.230  0.239  1.00 44.47  ? 128  ASN B CB    1 ? 
ATOM   5123 C CG    . ASN B 1 149 ? -33.408 28.539  0.591  1.00 51.48  ? 128  ASN B CG    1 ? 
ATOM   5124 O OD1   . ASN B 1 149 ? -34.464 28.842  0.022  1.00 63.39  ? 128  ASN B OD1   1 ? 
ATOM   5125 N ND2   . ASN B 1 149 ? -32.818 29.357  1.451  1.00 55.94  ? 128  ASN B ND2   1 ? 
ATOM   5126 N N     . LEU B 1 150 ? -30.807 27.616  3.265  1.00 38.47  ? 129  LEU B N     1 ? 
ATOM   5127 C CA    . LEU B 1 150 ? -29.579 28.095  3.889  1.00 40.29  ? 129  LEU B CA    1 ? 
ATOM   5128 C C     . LEU B 1 150 ? -28.543 26.978  3.996  1.00 37.28  ? 129  LEU B C     1 ? 
ATOM   5129 O O     . LEU B 1 150 ? -27.382 27.258  4.282  1.00 37.03  ? 129  LEU B O     1 ? 
ATOM   5130 C CB    . LEU B 1 150 ? -29.829 28.716  5.264  1.00 42.60  ? 129  LEU B CB    1 ? 
ATOM   5131 C CG    . LEU B 1 150 ? -30.358 30.148  5.250  1.00 46.36  ? 129  LEU B CG    1 ? 
ATOM   5132 C CD1   . LEU B 1 150 ? -30.871 30.562  6.623  1.00 47.78  ? 129  LEU B CD1   1 ? 
ATOM   5133 C CD2   . LEU B 1 150 ? -29.221 31.056  4.800  1.00 48.07  ? 129  LEU B CD2   1 ? 
ATOM   5134 N N     . GLY B 1 151 ? -28.978 25.724  3.825  1.00 34.63  ? 130  GLY B N     1 ? 
ATOM   5135 C CA    . GLY B 1 151 ? -28.077 24.582  3.818  1.00 36.73  ? 130  GLY B CA    1 ? 
ATOM   5136 C C     . GLY B 1 151 ? -27.916 24.044  2.393  1.00 36.64  ? 130  GLY B C     1 ? 
ATOM   5137 O O     . GLY B 1 151 ? -28.572 24.531  1.479  1.00 35.64  ? 130  GLY B O     1 ? 
ATOM   5138 N N     . PRO B 1 152 ? -27.086 23.000  2.146  1.00 39.33  ? 131  PRO B N     1 ? 
ATOM   5139 C CA    . PRO B 1 152 ? -26.296 22.344  3.195  1.00 39.81  ? 131  PRO B CA    1 ? 
ATOM   5140 C C     . PRO B 1 152 ? -25.096 23.165  3.655  1.00 41.37  ? 131  PRO B C     1 ? 
ATOM   5141 O O     . PRO B 1 152 ? -24.482 23.850  2.843  1.00 42.61  ? 131  PRO B O     1 ? 
ATOM   5142 C CB    . PRO B 1 152 ? -25.849 21.033  2.518  1.00 43.07  ? 131  PRO B CB    1 ? 
ATOM   5143 C CG    . PRO B 1 152 ? -25.750 21.398  1.044  1.00 42.45  ? 131  PRO B CG    1 ? 
ATOM   5144 C CD    . PRO B 1 152 ? -26.883 22.400  0.815  1.00 42.08  ? 131  PRO B CD    1 ? 
ATOM   5145 N N     . SER B 1 153 ? -24.789 23.084  4.959  1.00 38.24  ? 132  SER B N     1 ? 
ATOM   5146 C CA    . SER B 1 153 ? -23.613 23.722  5.528  1.00 40.66  ? 132  SER B CA    1 ? 
ATOM   5147 C C     . SER B 1 153 ? -23.359 23.161  6.927  1.00 41.83  ? 132  SER B C     1 ? 
ATOM   5148 O O     . SER B 1 153 ? -24.134 22.350  7.437  1.00 40.18  ? 132  SER B O     1 ? 
ATOM   5149 C CB    . SER B 1 153 ? -23.771 25.232  5.566  1.00 46.48  ? 132  SER B CB    1 ? 
ATOM   5150 O OG    . SER B 1 153 ? -24.674 25.646  6.592  1.00 44.56  ? 132  SER B OG    1 ? 
ATOM   5151 N N     . LYS B 1 154 ? -22.280 23.638  7.553  1.00 42.43  ? 133  LYS B N     1 ? 
ATOM   5152 C CA    . LYS B 1 154 ? -21.984 23.365  8.948  1.00 43.05  ? 133  LYS B CA    1 ? 
ATOM   5153 C C     . LYS B 1 154 ? -23.142 23.823  9.839  1.00 37.02  ? 133  LYS B C     1 ? 
ATOM   5154 O O     . LYS B 1 154 ? -23.370 23.238  10.882 1.00 36.77  ? 133  LYS B O     1 ? 
ATOM   5155 C CB    . LYS B 1 154 ? -20.710 24.143  9.313  1.00 46.69  ? 133  LYS B CB    1 ? 
ATOM   5156 C CG    . LYS B 1 154 ? -20.234 24.123  10.772 1.00 51.16  ? 133  LYS B CG    1 ? 
ATOM   5157 C CD    . LYS B 1 154 ? -19.229 25.243  11.048 1.00 53.39  ? 133  LYS B CD    1 ? 
ATOM   5158 C CE    . LYS B 1 154 ? -18.479 25.111  12.331 1.00 59.83  ? 133  LYS B CE    1 ? 
ATOM   5159 N NZ    . LYS B 1 154 ? -19.313 25.399  13.499 1.00 61.40  ? 133  LYS B NZ    1 ? 
ATOM   5160 N N     . TYR B 1 155 ? -23.858 24.881  9.432  1.00 37.45  ? 134  TYR B N     1 ? 
ATOM   5161 C CA    . TYR B 1 155 ? -24.843 25.529  10.285 1.00 36.51  ? 134  TYR B CA    1 ? 
ATOM   5162 C C     . TYR B 1 155 ? -26.264 25.000  10.048 1.00 37.16  ? 134  TYR B C     1 ? 
ATOM   5163 O O     . TYR B 1 155 ? -27.115 25.102  10.938 1.00 35.90  ? 134  TYR B O     1 ? 
ATOM   5164 C CB    . TYR B 1 155 ? -24.730 27.044  10.095 1.00 37.38  ? 134  TYR B CB    1 ? 
ATOM   5165 C CG    . TYR B 1 155 ? -23.435 27.617  10.665 1.00 41.21  ? 134  TYR B CG    1 ? 
ATOM   5166 C CD1   . TYR B 1 155 ? -23.191 27.595  12.036 1.00 45.01  ? 134  TYR B CD1   1 ? 
ATOM   5167 C CD2   . TYR B 1 155 ? -22.446 28.147  9.839  1.00 45.69  ? 134  TYR B CD2   1 ? 
ATOM   5168 C CE1   . TYR B 1 155 ? -22.003 28.074  12.572 1.00 49.17  ? 134  TYR B CE1   1 ? 
ATOM   5169 C CE2   . TYR B 1 155 ? -21.263 28.654  10.365 1.00 52.17  ? 134  TYR B CE2   1 ? 
ATOM   5170 C CZ    . TYR B 1 155 ? -21.037 28.608  11.733 1.00 51.46  ? 134  TYR B CZ    1 ? 
ATOM   5171 O OH    . TYR B 1 155 ? -19.880 29.100  12.274 1.00 57.76  ? 134  TYR B OH    1 ? 
ATOM   5172 N N     . HIS B 1 156 ? -26.556 24.482  8.851  1.00 34.54  ? 135  HIS B N     1 ? 
ATOM   5173 C CA    . HIS B 1 156 ? -27.931 24.226  8.449  1.00 34.49  ? 135  HIS B CA    1 ? 
ATOM   5174 C C     . HIS B 1 156 ? -28.051 22.940  7.640  1.00 39.29  ? 135  HIS B C     1 ? 
ATOM   5175 O O     . HIS B 1 156 ? -27.276 22.715  6.714  1.00 33.50  ? 135  HIS B O     1 ? 
ATOM   5176 C CB    . HIS B 1 156 ? -28.493 25.372  7.600  1.00 32.66  ? 135  HIS B CB    1 ? 
ATOM   5177 C CG    . HIS B 1 156 ? -28.538 26.677  8.315  1.00 36.21  ? 135  HIS B CG    1 ? 
ATOM   5178 N ND1   . HIS B 1 156 ? -29.319 26.863  9.439  1.00 37.42  ? 135  HIS B ND1   1 ? 
ATOM   5179 C CD2   . HIS B 1 156 ? -27.874 27.825  8.129  1.00 34.74  ? 135  HIS B CD2   1 ? 
ATOM   5180 C CE1   . HIS B 1 156 ? -29.146 28.104  9.883  1.00 36.45  ? 135  HIS B CE1   1 ? 
ATOM   5181 N NE2   . HIS B 1 156 ? -28.284 28.710  9.093  1.00 34.40  ? 135  HIS B NE2   1 ? 
ATOM   5182 N N     . GLY B 1 157 ? -29.084 22.150  7.977  1.00 35.80  ? 136  GLY B N     1 ? 
ATOM   5183 C CA    . GLY B 1 157 ? -29.531 21.041  7.155  1.00 32.76  ? 136  GLY B CA    1 ? 
ATOM   5184 C C     . GLY B 1 157 ? -30.329 21.485  5.930  1.00 34.20  ? 136  GLY B C     1 ? 
ATOM   5185 O O     . GLY B 1 157 ? -31.109 22.445  5.966  1.00 34.30  ? 136  GLY B O     1 ? 
ATOM   5186 N N     . ASP B 1 158 ? -30.165 20.712  4.847  1.00 32.22  ? 137  ASP B N     1 ? 
ATOM   5187 C CA    . ASP B 1 158 ? -30.937 20.898  3.631  1.00 30.04  ? 137  ASP B CA    1 ? 
ATOM   5188 C C     . ASP B 1 158 ? -31.948 19.780  3.452  1.00 27.62  ? 137  ASP B C     1 ? 
ATOM   5189 O O     . ASP B 1 158 ? -32.849 19.908  2.622  1.00 32.28  ? 137  ASP B O     1 ? 
ATOM   5190 C CB    . ASP B 1 158 ? -30.042 20.988  2.397  1.00 36.02  ? 137  ASP B CB    1 ? 
ATOM   5191 C CG    . ASP B 1 158 ? -29.111 19.804  2.162  1.00 37.81  ? 137  ASP B CG    1 ? 
ATOM   5192 O OD1   . ASP B 1 158 ? -28.775 19.123  3.150  1.00 35.35  ? 137  ASP B OD1   1 ? 
ATOM   5193 O OD2   . ASP B 1 158 ? -28.764 19.554  0.980  1.00 46.58  ? 137  ASP B OD2   1 ? 
ATOM   5194 N N     . LYS B 1 159 ? -31.827 18.691  4.217  1.00 29.72  ? 138  LYS B N     1 ? 
ATOM   5195 C CA    . LYS B 1 159 ? -32.644 17.518  3.956  1.00 31.39  ? 138  LYS B CA    1 ? 
ATOM   5196 C C     . LYS B 1 159 ? -33.314 16.990  5.216  1.00 33.66  ? 138  LYS B C     1 ? 
ATOM   5197 O O     . LYS B 1 159 ? -33.764 15.840  5.232  1.00 33.05  ? 138  LYS B O     1 ? 
ATOM   5198 C CB    . LYS B 1 159 ? -31.771 16.387  3.402  1.00 36.97  ? 138  LYS B CB    1 ? 
ATOM   5199 C CG    . LYS B 1 159 ? -31.123 16.656  2.057  1.00 42.45  ? 138  LYS B CG    1 ? 
ATOM   5200 C CD    . LYS B 1 159 ? -30.191 15.513  1.646  1.00 46.07  ? 138  LYS B CD    1 ? 
ATOM   5201 C CE    . LYS B 1 159 ? -29.289 15.845  0.498  1.00 51.43  ? 138  LYS B CE    1 ? 
ATOM   5202 N NZ    . LYS B 1 159 ? -30.058 16.398  -0.617 1.00 51.80  ? 138  LYS B NZ    1 ? 
ATOM   5203 N N     . GLY B 1 160 ? -33.425 17.830  6.249  1.00 32.01  ? 139  GLY B N     1 ? 
ATOM   5204 C CA    . GLY B 1 160 ? -34.016 17.390  7.503  1.00 33.47  ? 139  GLY B CA    1 ? 
ATOM   5205 C C     . GLY B 1 160 ? -35.534 17.305  7.413  1.00 29.92  ? 139  GLY B C     1 ? 
ATOM   5206 O O     . GLY B 1 160 ? -36.090 17.457  6.332  1.00 28.93  ? 139  GLY B O     1 ? 
ATOM   5207 N N     . LYS B 1 161 ? -36.192 17.074  8.567  1.00 28.43  ? 140  LYS B N     1 ? 
ATOM   5208 C CA    . LYS B 1 161 ? -37.616 16.790  8.595  1.00 26.33  ? 140  LYS B CA    1 ? 
ATOM   5209 C C     . LYS B 1 161 ? -38.460 18.049  8.426  1.00 27.56  ? 140  LYS B C     1 ? 
ATOM   5210 O O     . LYS B 1 161 ? -39.553 17.976  7.865  1.00 27.56  ? 140  LYS B O     1 ? 
ATOM   5211 C CB    . LYS B 1 161 ? -38.024 16.113  9.898  1.00 30.92  ? 140  LYS B CB    1 ? 
ATOM   5212 C CG    . LYS B 1 161 ? -37.552 14.674  10.008 1.00 33.82  ? 140  LYS B CG    1 ? 
ATOM   5213 C CD    . LYS B 1 161 ? -38.323 13.733  9.100  1.00 34.63  ? 140  LYS B CD    1 ? 
ATOM   5214 C CE    . LYS B 1 161 ? -37.772 12.344  9.290  1.00 38.77  ? 140  LYS B CE    1 ? 
ATOM   5215 N NZ    . LYS B 1 161 ? -38.530 11.452  8.426  1.00 41.14  ? 140  LYS B NZ    1 ? 
ATOM   5216 N N     . VAL B 1 162 ? -37.972 19.195  8.925  1.00 27.92  ? 141  VAL B N     1 ? 
ATOM   5217 C CA    . VAL B 1 162 ? -38.795 20.387  9.027  1.00 26.54  ? 141  VAL B CA    1 ? 
ATOM   5218 C C     . VAL B 1 162 ? -38.399 21.411  7.962  1.00 25.36  ? 141  VAL B C     1 ? 
ATOM   5219 O O     . VAL B 1 162 ? -37.349 22.034  8.041  1.00 28.01  ? 141  VAL B O     1 ? 
ATOM   5220 C CB    . VAL B 1 162 ? -38.704 21.030  10.428 1.00 27.50  ? 141  VAL B CB    1 ? 
ATOM   5221 C CG1   . VAL B 1 162 ? -39.629 22.241  10.524 1.00 27.84  ? 141  VAL B CG1   1 ? 
ATOM   5222 C CG2   . VAL B 1 162 ? -38.936 20.006  11.532 1.00 27.11  ? 141  VAL B CG2   1 ? 
ATOM   5223 N N     . LYS B 1 163 ? -39.288 21.603  7.000  1.00 27.16  ? 142  LYS B N     1 ? 
ATOM   5224 C CA    . LYS B 1 163 ? -39.109 22.551  5.920  1.00 27.84  ? 142  LYS B CA    1 ? 
ATOM   5225 C C     . LYS B 1 163 ? -39.237 23.972  6.454  1.00 28.23  ? 142  LYS B C     1 ? 
ATOM   5226 O O     . LYS B 1 163 ? -40.225 24.298  7.118  1.00 26.17  ? 142  LYS B O     1 ? 
ATOM   5227 C CB    . LYS B 1 163 ? -40.204 22.361  4.869  1.00 33.08  ? 142  LYS B CB    1 ? 
ATOM   5228 C CG    . LYS B 1 163 ? -40.160 23.324  3.687  1.00 39.42  ? 142  LYS B CG    1 ? 
ATOM   5229 C CD    . LYS B 1 163 ? -38.919 23.148  2.807  1.00 43.43  ? 142  LYS B CD    1 ? 
ATOM   5230 C CE    . LYS B 1 163 ? -39.030 23.807  1.465  1.00 47.60  ? 142  LYS B CE    1 ? 
ATOM   5231 N NZ    . LYS B 1 163 ? -38.349 25.099  1.485  1.00 48.86  ? 142  LYS B NZ    1 ? 
ATOM   5232 N N     . LEU B 1 164 ? -38.264 24.807  6.079  1.00 27.24  ? 143  LEU B N     1 ? 
ATOM   5233 C CA    . LEU B 1 164 ? -38.166 26.191  6.508  1.00 28.36  ? 143  LEU B CA    1 ? 
ATOM   5234 C C     . LEU B 1 164 ? -38.098 27.069  5.263  1.00 32.62  ? 143  LEU B C     1 ? 
ATOM   5235 O O     . LEU B 1 164 ? -37.305 26.783  4.372  1.00 33.66  ? 143  LEU B O     1 ? 
ATOM   5236 C CB    . LEU B 1 164 ? -36.931 26.379  7.391  1.00 27.58  ? 143  LEU B CB    1 ? 
ATOM   5237 C CG    . LEU B 1 164 ? -36.835 25.501  8.640  1.00 28.05  ? 143  LEU B CG    1 ? 
ATOM   5238 C CD1   . LEU B 1 164 ? -35.519 25.745  9.343  1.00 28.30  ? 143  LEU B CD1   1 ? 
ATOM   5239 C CD2   . LEU B 1 164 ? -38.030 25.792  9.580  1.00 30.83  ? 143  LEU B CD2   1 ? 
ATOM   5240 N N     . THR B 1 165 ? -38.957 28.096  5.201  1.00 29.43  ? 144  THR B N     1 ? 
ATOM   5241 C CA    . THR B 1 165 ? -39.024 29.016  4.080  1.00 33.49  ? 144  THR B CA    1 ? 
ATOM   5242 C C     . THR B 1 165 ? -38.990 30.447  4.614  1.00 33.08  ? 144  THR B C     1 ? 
ATOM   5243 O O     . THR B 1 165 ? -39.496 30.739  5.701  1.00 29.41  ? 144  THR B O     1 ? 
ATOM   5244 C CB    . THR B 1 165 ? -40.287 28.758  3.254  1.00 35.03  ? 144  THR B CB    1 ? 
ATOM   5245 O OG1   . THR B 1 165 ? -41.420 28.768  4.117  1.00 37.55  ? 144  THR B OG1   1 ? 
ATOM   5246 C CG2   . THR B 1 165 ? -40.298 27.401  2.583  1.00 38.06  ? 144  THR B CG2   1 ? 
ATOM   5247 N N     . ASP B 1 166 ? -38.392 31.341  3.830  1.00 31.73  ? 145  ASP B N     1 ? 
ATOM   5248 C CA    . ASP B 1 166 ? -38.374 32.762  4.133  1.00 29.56  ? 145  ASP B CA    1 ? 
ATOM   5249 C C     . ASP B 1 166 ? -39.791 33.298  4.284  1.00 27.72  ? 145  ASP B C     1 ? 
ATOM   5250 O O     . ASP B 1 166 ? -40.688 32.861  3.576  1.00 27.97  ? 145  ASP B O     1 ? 
ATOM   5251 C CB    . ASP B 1 166 ? -37.707 33.558  3.020  1.00 34.36  ? 145  ASP B CB    1 ? 
ATOM   5252 C CG    . ASP B 1 166 ? -36.219 33.290  2.825  1.00 38.81  ? 145  ASP B CG    1 ? 
ATOM   5253 O OD1   . ASP B 1 166 ? -35.608 32.525  3.623  1.00 37.41  ? 145  ASP B OD1   1 ? 
ATOM   5254 O OD2   . ASP B 1 166 ? -35.676 33.855  1.862  1.00 43.66  ? 145  ASP B OD2   1 ? 
ATOM   5255 N N     . SER B 1 167 ? -39.986 34.214  5.249  1.00 29.23  ? 146  SER B N     1 ? 
ATOM   5256 C CA    . SER B 1 167 ? -41.258 34.901  5.417  1.00 28.55  ? 146  SER B CA    1 ? 
ATOM   5257 C C     . SER B 1 167 ? -41.633 35.556  4.095  1.00 32.14  ? 146  SER B C     1 ? 
ATOM   5258 O O     . SER B 1 167 ? -40.776 36.167  3.472  1.00 30.57  ? 146  SER B O     1 ? 
ATOM   5259 C CB    . SER B 1 167 ? -41.206 35.954  6.520  1.00 27.70  ? 146  SER B CB    1 ? 
ATOM   5260 O OG    . SER B 1 167 ? -40.886 35.370  7.783  1.00 25.66  ? 146  SER B OG    1 ? 
ATOM   5261 N N     . SER B 1 168 ? -42.908 35.467  3.712  1.00 30.84  ? 147  SER B N     1 ? 
ATOM   5262 C CA    . SER B 1 168 ? -43.363 36.158  2.523  1.00 37.84  ? 147  SER B CA    1 ? 
ATOM   5263 C C     . SER B 1 168 ? -43.754 37.584  2.912  1.00 34.22  ? 147  SER B C     1 ? 
ATOM   5264 O O     . SER B 1 168 ? -44.207 37.841  4.040  1.00 29.87  ? 147  SER B O     1 ? 
ATOM   5265 C CB    . SER B 1 168 ? -44.458 35.374  1.804  1.00 41.45  ? 147  SER B CB    1 ? 
ATOM   5266 O OG    . SER B 1 168 ? -45.573 35.097  2.638  1.00 54.59  ? 147  SER B OG    1 ? 
ATOM   5267 N N     . TYR B 1 169 ? -43.484 38.540  2.019  1.00 31.57  ? 148  TYR B N     1 ? 
ATOM   5268 C CA    . TYR B 1 169 ? -43.823 39.932  2.303  1.00 31.56  ? 148  TYR B CA    1 ? 
ATOM   5269 C C     . TYR B 1 169 ? -44.097 40.681  1.003  1.00 33.54  ? 148  TYR B C     1 ? 
ATOM   5270 O O     . TYR B 1 169 ? -43.512 40.347  -0.016 1.00 29.71  ? 148  TYR B O     1 ? 
ATOM   5271 C CB    . TYR B 1 169 ? -42.746 40.660  3.100  1.00 31.06  ? 148  TYR B CB    1 ? 
ATOM   5272 C CG    . TYR B 1 169 ? -41.353 40.552  2.508  1.00 34.42  ? 148  TYR B CG    1 ? 
ATOM   5273 C CD1   . TYR B 1 169 ? -40.885 41.501  1.612  1.00 33.98  ? 148  TYR B CD1   1 ? 
ATOM   5274 C CD2   . TYR B 1 169 ? -40.496 39.520  2.885  1.00 36.75  ? 148  TYR B CD2   1 ? 
ATOM   5275 C CE1   . TYR B 1 169 ? -39.615 41.413  1.071  1.00 37.31  ? 148  TYR B CE1   1 ? 
ATOM   5276 C CE2   . TYR B 1 169 ? -39.211 39.439  2.371  1.00 41.04  ? 148  TYR B CE2   1 ? 
ATOM   5277 C CZ    . TYR B 1 169 ? -38.778 40.379  1.450  1.00 41.32  ? 148  TYR B CZ    1 ? 
ATOM   5278 O OH    . TYR B 1 169 ? -37.531 40.275  0.923  1.00 45.75  ? 148  TYR B OH    1 ? 
ATOM   5279 N N     . PRO B 1 170 ? -44.997 41.693  1.005  1.00 33.12  ? 149  PRO B N     1 ? 
ATOM   5280 C CA    . PRO B 1 170 ? -45.411 42.370  -0.226 1.00 36.22  ? 149  PRO B CA    1 ? 
ATOM   5281 C C     . PRO B 1 170 ? -44.654 43.619  -0.647 1.00 38.47  ? 149  PRO B C     1 ? 
ATOM   5282 O O     . PRO B 1 170 ? -44.939 44.171  -1.705 1.00 37.68  ? 149  PRO B O     1 ? 
ATOM   5283 C CB    . PRO B 1 170 ? -46.853 42.740  0.162  1.00 36.57  ? 149  PRO B CB    1 ? 
ATOM   5284 C CG    . PRO B 1 170 ? -46.738 43.158  1.587  1.00 35.66  ? 149  PRO B CG    1 ? 
ATOM   5285 C CD    . PRO B 1 170 ? -45.761 42.156  2.172  1.00 33.62  ? 149  PRO B CD    1 ? 
ATOM   5286 N N     . THR B 1 171 ? -43.729 44.081  0.193  1.00 32.28  ? 150  THR B N     1 ? 
ATOM   5287 C CA    . THR B 1 171 ? -43.177 45.416  0.026  1.00 33.25  ? 150  THR B CA    1 ? 
ATOM   5288 C C     . THR B 1 171 ? -41.656 45.358  -0.048 1.00 34.69  ? 150  THR B C     1 ? 
ATOM   5289 O O     . THR B 1 171 ? -40.999 44.684  0.749  1.00 34.32  ? 150  THR B O     1 ? 
ATOM   5290 C CB    . THR B 1 171 ? -43.616 46.340  1.160  1.00 32.89  ? 150  THR B CB    1 ? 
ATOM   5291 O OG1   . THR B 1 171 ? -43.037 47.596  0.805  1.00 31.81  ? 150  THR B OG1   1 ? 
ATOM   5292 C CG2   . THR B 1 171 ? -43.122 45.885  2.524  1.00 34.14  ? 150  THR B CG2   1 ? 
ATOM   5293 N N     . PRO B 1 172 ? -41.044 46.120  -0.987 1.00 38.85  ? 151  PRO B N     1 ? 
ATOM   5294 C CA    . PRO B 1 172 ? -39.587 46.221  -1.056 1.00 36.10  ? 151  PRO B CA    1 ? 
ATOM   5295 C C     . PRO B 1 172 ? -38.998 46.995  0.122  1.00 31.49  ? 151  PRO B C     1 ? 
ATOM   5296 O O     . PRO B 1 172 ? -37.801 46.987  0.340  1.00 28.46  ? 151  PRO B O     1 ? 
ATOM   5297 C CB    . PRO B 1 172 ? -39.365 46.923  -2.438 1.00 41.42  ? 151  PRO B CB    1 ? 
ATOM   5298 C CG    . PRO B 1 172 ? -40.617 47.768  -2.641 1.00 42.89  ? 151  PRO B CG    1 ? 
ATOM   5299 C CD    . PRO B 1 172 ? -41.724 46.902  -2.043 1.00 42.48  ? 151  PRO B CD    1 ? 
ATOM   5300 N N     . PHE B 1 173 ? -39.844 47.639  0.922  1.00 31.01  ? 152  PHE B N     1 ? 
ATOM   5301 C CA    . PHE B 1 173 ? -39.391 48.369  2.096  1.00 33.71  ? 152  PHE B CA    1 ? 
ATOM   5302 C C     . PHE B 1 173 ? -38.626 47.467  3.081  1.00 34.20  ? 152  PHE B C     1 ? 
ATOM   5303 O O     . PHE B 1 173 ? -37.887 47.973  3.918  1.00 33.75  ? 152  PHE B O     1 ? 
ATOM   5304 C CB    . PHE B 1 173 ? -40.616 49.041  2.731  1.00 37.25  ? 152  PHE B CB    1 ? 
ATOM   5305 C CG    . PHE B 1 173 ? -40.280 49.874  3.958  1.00 37.90  ? 152  PHE B CG    1 ? 
ATOM   5306 C CD1   . PHE B 1 173 ? -39.738 51.148  3.824  1.00 36.80  ? 152  PHE B CD1   1 ? 
ATOM   5307 C CD2   . PHE B 1 173 ? -40.493 49.377  5.242  1.00 36.90  ? 152  PHE B CD2   1 ? 
ATOM   5308 C CE1   . PHE B 1 173 ? -39.419 51.902  4.945  1.00 35.60  ? 152  PHE B CE1   1 ? 
ATOM   5309 C CE2   . PHE B 1 173 ? -40.148 50.124  6.348  1.00 34.12  ? 152  PHE B CE2   1 ? 
ATOM   5310 C CZ    . PHE B 1 173 ? -39.625 51.387  6.199  1.00 38.14  ? 152  PHE B CZ    1 ? 
ATOM   5311 N N     . VAL B 1 174 ? -38.775 46.139  2.989  1.00 35.25  ? 153  VAL B N     1 ? 
ATOM   5312 C CA    . VAL B 1 174 ? -38.035 45.247  3.871  1.00 35.78  ? 153  VAL B CA    1 ? 
ATOM   5313 C C     . VAL B 1 174 ? -36.535 45.487  3.682  1.00 40.24  ? 153  VAL B C     1 ? 
ATOM   5314 O O     . VAL B 1 174 ? -35.792 45.478  4.654  1.00 38.33  ? 153  VAL B O     1 ? 
ATOM   5315 C CB    . VAL B 1 174 ? -38.442 43.768  3.687  1.00 40.90  ? 153  VAL B CB    1 ? 
ATOM   5316 C CG1   . VAL B 1 174 ? -37.514 42.806  4.420  1.00 41.72  ? 153  VAL B CG1   1 ? 
ATOM   5317 C CG2   . VAL B 1 174 ? -39.877 43.529  4.146  1.00 37.13  ? 153  VAL B CG2   1 ? 
ATOM   5318 N N     . HIS B 1 175 ? -36.099 45.801  2.454  1.00 42.04  ? 154  HIS B N     1 ? 
ATOM   5319 C CA    . HIS B 1 175 ? -34.693 46.114  2.192  1.00 46.16  ? 154  HIS B CA    1 ? 
ATOM   5320 C C     . HIS B 1 175 ? -34.223 47.347  2.970  1.00 36.50  ? 154  HIS B C     1 ? 
ATOM   5321 O O     . HIS B 1 175 ? -33.115 47.360  3.504  1.00 36.91  ? 154  HIS B O     1 ? 
ATOM   5322 C CB    . HIS B 1 175 ? -34.434 46.248  0.683  1.00 51.62  ? 154  HIS B CB    1 ? 
ATOM   5323 C CG    . HIS B 1 175 ? -34.746 44.990  -0.048 1.00 60.24  ? 154  HIS B CG    1 ? 
ATOM   5324 N ND1   . HIS B 1 175 ? -34.008 43.834  0.098  1.00 74.54  ? 154  HIS B ND1   1 ? 
ATOM   5325 C CD2   . HIS B 1 175 ? -35.749 44.687  -0.873 1.00 69.25  ? 154  HIS B CD2   1 ? 
ATOM   5326 C CE1   . HIS B 1 175 ? -34.550 42.876  -0.643 1.00 74.15  ? 154  HIS B CE1   1 ? 
ATOM   5327 N NE2   . HIS B 1 175 ? -35.604 43.375  -1.247 1.00 69.97  ? 154  HIS B NE2   1 ? 
ATOM   5328 N N     . THR B 1 176 ? -35.078 48.373  3.037  1.00 31.55  ? 155  THR B N     1 ? 
ATOM   5329 C CA    . THR B 1 176 ? -34.796 49.609  3.745  1.00 33.70  ? 155  THR B CA    1 ? 
ATOM   5330 C C     . THR B 1 176 ? -34.588 49.337  5.241  1.00 32.33  ? 155  THR B C     1 ? 
ATOM   5331 O O     . THR B 1 176 ? -33.769 49.982  5.878  1.00 33.08  ? 155  THR B O     1 ? 
ATOM   5332 C CB    . THR B 1 176 ? -35.955 50.578  3.511  1.00 36.32  ? 155  THR B CB    1 ? 
ATOM   5333 O OG1   . THR B 1 176 ? -36.320 50.528  2.135  1.00 42.24  ? 155  THR B OG1   1 ? 
ATOM   5334 C CG2   . THR B 1 176 ? -35.640 51.996  3.930  1.00 36.93  ? 155  THR B CG2   1 ? 
ATOM   5335 N N     . LEU B 1 177 ? -35.335 48.378  5.807  1.00 34.99  ? 156  LEU B N     1 ? 
ATOM   5336 C CA    . LEU B 1 177 ? -35.206 48.031  7.218  1.00 34.83  ? 156  LEU B CA    1 ? 
ATOM   5337 C C     . LEU B 1 177 ? -33.863 47.348  7.462  1.00 32.12  ? 156  LEU B C     1 ? 
ATOM   5338 O O     . LEU B 1 177 ? -33.175 47.656  8.438  1.00 30.88  ? 156  LEU B O     1 ? 
ATOM   5339 C CB    . LEU B 1 177 ? -36.375 47.138  7.648  1.00 30.98  ? 156  LEU B CB    1 ? 
ATOM   5340 C CG    . LEU B 1 177 ? -37.740 47.828  7.667  1.00 32.71  ? 156  LEU B CG    1 ? 
ATOM   5341 C CD1   . LEU B 1 177 ? -38.886 46.814  7.703  1.00 33.82  ? 156  LEU B CD1   1 ? 
ATOM   5342 C CD2   . LEU B 1 177 ? -37.807 48.816  8.813  1.00 33.82  ? 156  LEU B CD2   1 ? 
ATOM   5343 N N     . LEU B 1 178 ? -33.505 46.419  6.576  1.00 31.85  ? 157  LEU B N     1 ? 
ATOM   5344 C CA    . LEU B 1 178 ? -32.255 45.693  6.707  1.00 34.32  ? 157  LEU B CA    1 ? 
ATOM   5345 C C     . LEU B 1 178 ? -31.097 46.687  6.621  1.00 36.03  ? 157  LEU B C     1 ? 
ATOM   5346 O O     . LEU B 1 178 ? -30.184 46.615  7.433  1.00 32.13  ? 157  LEU B O     1 ? 
ATOM   5347 C CB    . LEU B 1 178 ? -32.100 44.592  5.661  1.00 37.10  ? 157  LEU B CB    1 ? 
ATOM   5348 C CG    . LEU B 1 178 ? -33.145 43.464  5.649  1.00 44.67  ? 157  LEU B CG    1 ? 
ATOM   5349 C CD1   . LEU B 1 178 ? -32.594 42.259  4.911  1.00 46.28  ? 157  LEU B CD1   1 ? 
ATOM   5350 C CD2   . LEU B 1 178 ? -33.631 43.036  7.001  1.00 40.57  ? 157  LEU B CD2   1 ? 
ATOM   5351 N N     . ASN B 1 179 ? -31.159 47.625  5.656  1.00 36.64  ? 158  ASN B N     1 ? 
ATOM   5352 C CA    . ASN B 1 179 ? -30.105 48.618  5.478  1.00 34.72  ? 158  ASN B CA    1 ? 
ATOM   5353 C C     . ASN B 1 179 ? -30.035 49.539  6.690  1.00 31.73  ? 158  ASN B C     1 ? 
ATOM   5354 O O     . ASN B 1 179 ? -28.947 49.881  7.132  1.00 41.14  ? 158  ASN B O     1 ? 
ATOM   5355 C CB    . ASN B 1 179 ? -30.324 49.480  4.241  1.00 36.47  ? 158  ASN B CB    1 ? 
ATOM   5356 C CG    . ASN B 1 179 ? -30.232 48.708  2.953  1.00 36.90  ? 158  ASN B CG    1 ? 
ATOM   5357 O OD1   . ASN B 1 179 ? -29.554 47.681  2.894  1.00 41.28  ? 158  ASN B OD1   1 ? 
ATOM   5358 N ND2   . ASN B 1 179 ? -30.899 49.196  1.920  1.00 39.77  ? 158  ASN B ND2   1 ? 
ATOM   5359 N N     . GLY B 1 180 ? -31.192 49.931  7.229  1.00 29.24  ? 159  GLY B N     1 ? 
ATOM   5360 C CA    . GLY B 1 180 ? -31.254 50.762  8.426  1.00 32.15  ? 159  GLY B CA    1 ? 
ATOM   5361 C C     . GLY B 1 180 ? -30.510 50.149  9.614  1.00 31.48  ? 159  GLY B C     1 ? 
ATOM   5362 O O     . GLY B 1 180 ? -29.814 50.849  10.341 1.00 37.02  ? 159  GLY B O     1 ? 
ATOM   5363 N N     . PHE B 1 181 ? -30.702 48.843  9.847  1.00 31.69  ? 160  PHE B N     1 ? 
ATOM   5364 C CA    . PHE B 1 181 ? -30.010 48.135  10.916 1.00 31.69  ? 160  PHE B CA    1 ? 
ATOM   5365 C C     . PHE B 1 181 ? -28.497 48.202  10.698 1.00 34.28  ? 160  PHE B C     1 ? 
ATOM   5366 O O     . PHE B 1 181 ? -27.736 48.465  11.625 1.00 32.35  ? 160  PHE B O     1 ? 
ATOM   5367 C CB    . PHE B 1 181 ? -30.540 46.701  10.921 1.00 30.06  ? 160  PHE B CB    1 ? 
ATOM   5368 C CG    . PHE B 1 181 ? -29.915 45.738  11.914 1.00 30.54  ? 160  PHE B CG    1 ? 
ATOM   5369 C CD1   . PHE B 1 181 ? -28.737 45.075  11.610 1.00 28.01  ? 160  PHE B CD1   1 ? 
ATOM   5370 C CD2   . PHE B 1 181 ? -30.553 45.433  13.125 1.00 30.29  ? 160  PHE B CD2   1 ? 
ATOM   5371 C CE1   . PHE B 1 181 ? -28.189 44.156  12.485 1.00 28.29  ? 160  PHE B CE1   1 ? 
ATOM   5372 C CE2   . PHE B 1 181 ? -29.996 44.521  14.016 1.00 26.56  ? 160  PHE B CE2   1 ? 
ATOM   5373 C CZ    . PHE B 1 181 ? -28.818 43.866  13.687 1.00 27.56  ? 160  PHE B CZ    1 ? 
ATOM   5374 N N     . LYS B 1 182 ? -28.049 47.939  9.465  1.00 36.55  ? 161  LYS B N     1 ? 
ATOM   5375 C CA    . LYS B 1 182 ? -26.624 48.001  9.171  1.00 39.17  ? 161  LYS B CA    1 ? 
ATOM   5376 C C     . LYS B 1 182 ? -26.108 49.424  9.376  1.00 34.69  ? 161  LYS B C     1 ? 
ATOM   5377 O O     . LYS B 1 182 ? -25.130 49.620  10.081 1.00 37.32  ? 161  LYS B O     1 ? 
ATOM   5378 C CB    . LYS B 1 182 ? -26.284 47.491  7.768  1.00 45.75  ? 161  LYS B CB    1 ? 
ATOM   5379 C CG    . LYS B 1 182 ? -24.780 47.439  7.533  1.00 50.88  ? 161  LYS B CG    1 ? 
ATOM   5380 C CD    . LYS B 1 182 ? -24.354 46.630  6.320  1.00 59.04  ? 161  LYS B CD    1 ? 
ATOM   5381 C CE    . LYS B 1 182 ? -22.865 46.471  6.291  1.00 63.87  ? 161  LYS B CE    1 ? 
ATOM   5382 N NZ    . LYS B 1 182 ? -22.480 45.720  5.098  1.00 68.24  ? 161  LYS B NZ    1 ? 
ATOM   5383 N N     . GLU B 1 183 ? -26.812 50.408  8.809  1.00 36.10  ? 162  GLU B N     1 ? 
ATOM   5384 C CA    . GLU B 1 183 ? -26.381 51.799  8.868  1.00 38.37  ? 162  GLU B CA    1 ? 
ATOM   5385 C C     . GLU B 1 183 ? -26.301 52.280  10.308 1.00 41.67  ? 162  GLU B C     1 ? 
ATOM   5386 O O     . GLU B 1 183 ? -25.518 53.165  10.598 1.00 40.58  ? 162  GLU B O     1 ? 
ATOM   5387 C CB    . GLU B 1 183 ? -27.336 52.737  8.136  1.00 37.45  ? 162  GLU B CB    1 ? 
ATOM   5388 C CG    . GLU B 1 183 ? -27.322 52.538  6.626  1.00 36.59  ? 162  GLU B CG    1 ? 
ATOM   5389 C CD    . GLU B 1 183 ? -28.509 53.182  5.955  1.00 38.56  ? 162  GLU B CD    1 ? 
ATOM   5390 O OE1   . GLU B 1 183 ? -28.787 52.823  4.800  1.00 40.64  ? 162  GLU B OE1   1 ? 
ATOM   5391 O OE2   . GLU B 1 183 ? -29.158 54.022  6.593  1.00 40.36  ? 162  GLU B OE2   1 ? 
ATOM   5392 N N     . ALA B 1 184 ? -27.125 51.717  11.207 1.00 40.62  ? 163  ALA B N     1 ? 
ATOM   5393 C CA    . ALA B 1 184 ? -27.133 52.179  12.581 1.00 36.45  ? 163  ALA B CA    1 ? 
ATOM   5394 C C     . ALA B 1 184 ? -25.930 51.636  13.329 1.00 33.55  ? 163  ALA B C     1 ? 
ATOM   5395 O O     . ALA B 1 184 ? -25.715 52.057  14.451 1.00 36.66  ? 163  ALA B O     1 ? 
ATOM   5396 C CB    . ALA B 1 184 ? -28.419 51.786  13.285 1.00 40.60  ? 163  ALA B CB    1 ? 
ATOM   5397 N N     . GLY B 1 185 ? -25.191 50.684  12.741 1.00 34.23  ? 164  GLY B N     1 ? 
ATOM   5398 C CA    . GLY B 1 185 ? -24.089 50.041  13.447 1.00 34.11  ? 164  GLY B CA    1 ? 
ATOM   5399 C C     . GLY B 1 185 ? -24.538 48.850  14.309 1.00 36.97  ? 164  GLY B C     1 ? 
ATOM   5400 O O     . GLY B 1 185 ? -23.797 48.407  15.174 1.00 35.93  ? 164  GLY B O     1 ? 
ATOM   5401 N N     . PHE B 1 186 ? -25.742 48.310  14.079 1.00 36.63  ? 165  PHE B N     1 ? 
ATOM   5402 C CA    . PHE B 1 186 ? -26.254 47.216  14.908 1.00 35.76  ? 165  PHE B CA    1 ? 
ATOM   5403 C C     . PHE B 1 186 ? -25.577 45.895  14.562 1.00 34.50  ? 165  PHE B C     1 ? 
ATOM   5404 O O     . PHE B 1 186 ? -25.481 45.015  15.416 1.00 35.51  ? 165  PHE B O     1 ? 
ATOM   5405 C CB    . PHE B 1 186 ? -27.768 47.089  14.740 1.00 33.71  ? 165  PHE B CB    1 ? 
ATOM   5406 C CG    . PHE B 1 186 ? -28.571 48.236  15.326 1.00 31.99  ? 165  PHE B CG    1 ? 
ATOM   5407 C CD1   . PHE B 1 186 ? -27.968 49.191  16.145 1.00 32.95  ? 165  PHE B CD1   1 ? 
ATOM   5408 C CD2   . PHE B 1 186 ? -29.937 48.354  15.070 1.00 31.83  ? 165  PHE B CD2   1 ? 
ATOM   5409 C CE1   . PHE B 1 186 ? -28.702 50.229  16.668 1.00 31.50  ? 165  PHE B CE1   1 ? 
ATOM   5410 C CE2   . PHE B 1 186 ? -30.667 49.407  15.597 1.00 32.29  ? 165  PHE B CE2   1 ? 
ATOM   5411 C CZ    . PHE B 1 186 ? -30.050 50.335  16.395 1.00 35.26  ? 165  PHE B CZ    1 ? 
ATOM   5412 N N     . GLY B 1 187 ? -25.077 45.775  13.320 1.00 36.14  ? 166  GLY B N     1 ? 
ATOM   5413 C CA    . GLY B 1 187 ? -24.470 44.539  12.847 1.00 32.95  ? 166  GLY B CA    1 ? 
ATOM   5414 C C     . GLY B 1 187 ? -24.663 44.350  11.345 1.00 31.84  ? 166  GLY B C     1 ? 
ATOM   5415 O O     . GLY B 1 187 ? -24.913 45.290  10.608 1.00 32.42  ? 166  GLY B O     1 ? 
ATOM   5416 N N     . GLU B 1 188 ? -24.556 43.102  10.890 1.00 34.81  ? 167  GLU B N     1 ? 
ATOM   5417 C CA    . GLU B 1 188 ? -24.492 42.821  9.467  1.00 39.51  ? 167  GLU B CA    1 ? 
ATOM   5418 C C     . GLU B 1 188 ? -25.844 42.328  8.971  1.00 41.47  ? 167  GLU B C     1 ? 
ATOM   5419 O O     . GLU B 1 188 ? -26.720 41.998  9.773  1.00 33.03  ? 167  GLU B O     1 ? 
ATOM   5420 C CB    . GLU B 1 188 ? -23.389 41.800  9.190  1.00 40.65  ? 167  GLU B CB    1 ? 
ATOM   5421 C CG    . GLU B 1 188 ? -21.996 42.333  9.545  1.00 43.95  ? 167  GLU B CG    1 ? 
ATOM   5422 C CD    . GLU B 1 188 ? -21.556 43.526  8.706  1.00 42.08  ? 167  GLU B CD    1 ? 
ATOM   5423 O OE1   . GLU B 1 188 ? -21.147 44.593  9.216  1.00 39.71  ? 167  GLU B OE1   1 ? 
ATOM   5424 O OE2   . GLU B 1 188 ? -21.674 43.376  7.475  1.00 44.30  ? 167  GLU B OE2   1 ? 
ATOM   5425 N N     . ILE B 1 189 ? -25.985 42.313  7.640  1.00 34.67  ? 168  ILE B N     1 ? 
ATOM   5426 C CA    . ILE B 1 189 ? -27.104 41.660  6.991  1.00 34.97  ? 168  ILE B CA    1 ? 
ATOM   5427 C C     . ILE B 1 189 ? -26.669 40.239  6.666  1.00 34.70  ? 168  ILE B C     1 ? 
ATOM   5428 O O     . ILE B 1 189 ? -25.673 40.064  5.988  1.00 38.15  ? 168  ILE B O     1 ? 
ATOM   5429 C CB    . ILE B 1 189 ? -27.523 42.437  5.736  1.00 38.31  ? 168  ILE B CB    1 ? 
ATOM   5430 C CG1   . ILE B 1 189 ? -27.969 43.865  6.100  1.00 40.56  ? 168  ILE B CG1   1 ? 
ATOM   5431 C CG2   . ILE B 1 189 ? -28.578 41.649  4.958  1.00 39.23  ? 168  ILE B CG2   1 ? 
ATOM   5432 C CD1   . ILE B 1 189 ? -28.241 44.788  4.913  1.00 38.42  ? 168  ILE B CD1   1 ? 
ATOM   5433 N N     . GLY B 1 190 ? -27.407 39.236  7.150  1.00 32.23  ? 169  GLY B N     1 ? 
ATOM   5434 C CA    . GLY B 1 190 ? -26.968 37.855  7.055  1.00 34.36  ? 169  GLY B CA    1 ? 
ATOM   5435 C C     . GLY B 1 190 ? -27.588 36.976  8.134  1.00 32.66  ? 169  GLY B C     1 ? 
ATOM   5436 O O     . GLY B 1 190 ? -28.415 37.427  8.921  1.00 33.00  ? 169  GLY B O     1 ? 
ATOM   5437 N N     . ASP B 1 191 ? -27.108 35.738  8.181  1.00 38.51  ? 170  ASP B N     1 ? 
ATOM   5438 C CA    . ASP B 1 191 ? -27.769 34.650  8.877  1.00 36.58  ? 170  ASP B CA    1 ? 
ATOM   5439 C C     . ASP B 1 191 ? -27.396 34.682  10.353 1.00 35.12  ? 170  ASP B C     1 ? 
ATOM   5440 O O     . ASP B 1 191 ? -26.288 34.298  10.725 1.00 33.67  ? 170  ASP B O     1 ? 
ATOM   5441 C CB    . ASP B 1 191 ? -27.400 33.323  8.245  1.00 38.52  ? 170  ASP B CB    1 ? 
ATOM   5442 C CG    . ASP B 1 191 ? -27.953 32.101  8.960  1.00 39.37  ? 170  ASP B CG    1 ? 
ATOM   5443 O OD1   . ASP B 1 191 ? -28.992 32.249  9.648  1.00 36.69  ? 170  ASP B OD1   1 ? 
ATOM   5444 O OD2   . ASP B 1 191 ? -27.298 31.037  8.868  1.00 40.93  ? 170  ASP B OD2   1 ? 
ATOM   5445 N N     . TYR B 1 192 ? -28.334 35.123  11.212 1.00 32.07  ? 171  TYR B N     1 ? 
ATOM   5446 C CA    . TYR B 1 192 ? -28.034 35.249  12.636 1.00 29.98  ? 171  TYR B CA    1 ? 
ATOM   5447 C C     . TYR B 1 192 ? -27.783 33.882  13.269 1.00 29.80  ? 171  TYR B C     1 ? 
ATOM   5448 O O     . TYR B 1 192 ? -27.192 33.828  14.341 1.00 32.55  ? 171  TYR B O     1 ? 
ATOM   5449 C CB    . TYR B 1 192 ? -29.121 36.059  13.355 1.00 28.57  ? 171  TYR B CB    1 ? 
ATOM   5450 C CG    . TYR B 1 192 ? -30.525 35.752  12.873 1.00 26.84  ? 171  TYR B CG    1 ? 
ATOM   5451 C CD1   . TYR B 1 192 ? -31.095 34.499  13.093 1.00 27.25  ? 171  TYR B CD1   1 ? 
ATOM   5452 C CD2   . TYR B 1 192 ? -31.291 36.715  12.244 1.00 27.72  ? 171  TYR B CD2   1 ? 
ATOM   5453 C CE1   . TYR B 1 192 ? -32.366 34.201  12.631 1.00 23.82  ? 171  TYR B CE1   1 ? 
ATOM   5454 C CE2   . TYR B 1 192 ? -32.571 36.439  11.807 1.00 30.05  ? 171  TYR B CE2   1 ? 
ATOM   5455 C CZ    . TYR B 1 192 ? -33.109 35.183  12.013 1.00 27.70  ? 171  TYR B CZ    1 ? 
ATOM   5456 O OH    . TYR B 1 192 ? -34.348 34.940  11.570 1.00 28.15  ? 171  TYR B OH    1 ? 
ATOM   5457 N N     . ALA B 1 193 ? -28.224 32.790  12.614 1.00 31.55  ? 172  ALA B N     1 ? 
ATOM   5458 C CA    . ALA B 1 193 ? -28.012 31.440  13.118 1.00 35.16  ? 172  ALA B CA    1 ? 
ATOM   5459 C C     . ALA B 1 193 ? -26.781 30.794  12.480 1.00 40.11  ? 172  ALA B C     1 ? 
ATOM   5460 O O     . ALA B 1 193 ? -26.602 29.572  12.564 1.00 36.09  ? 172  ALA B O     1 ? 
ATOM   5461 C CB    . ALA B 1 193 ? -29.248 30.603  12.843 1.00 35.79  ? 172  ALA B CB    1 ? 
ATOM   5462 N N     . GLY B 1 194 ? -25.955 31.626  11.826 1.00 43.42  ? 173  GLY B N     1 ? 
ATOM   5463 C CA    . GLY B 1 194 ? -24.778 31.166  11.103 1.00 46.23  ? 173  GLY B CA    1 ? 
ATOM   5464 C C     . GLY B 1 194 ? -23.497 31.595  11.810 1.00 48.94  ? 173  GLY B C     1 ? 
ATOM   5465 O O     . GLY B 1 194 ? -23.416 31.526  13.034 1.00 48.18  ? 173  GLY B O     1 ? 
ATOM   5466 N N     . GLU B 1 195 ? -22.513 32.067  11.027 1.00 53.26  ? 174  GLU B N     1 ? 
ATOM   5467 C CA    . GLU B 1 195 ? -21.208 32.426  11.565 1.00 51.46  ? 174  GLU B CA    1 ? 
ATOM   5468 C C     . GLU B 1 195 ? -21.306 33.695  12.409 1.00 45.65  ? 174  GLU B C     1 ? 
ATOM   5469 O O     . GLU B 1 195 ? -20.712 33.761  13.480 1.00 42.46  ? 174  GLU B O     1 ? 
ATOM   5470 C CB    . GLU B 1 195 ? -20.135 32.631  10.492 1.00 60.51  ? 174  GLU B CB    1 ? 
ATOM   5471 C CG    . GLU B 1 195 ? -18.734 32.734  11.093 1.00 67.52  ? 174  GLU B CG    1 ? 
ATOM   5472 C CD    . GLU B 1 195 ? -17.564 32.830  10.128 1.00 77.11  ? 174  GLU B CD    1 ? 
ATOM   5473 O OE1   . GLU B 1 195 ? -16.465 33.157  10.628 1.00 79.38  ? 174  GLU B OE1   1 ? 
ATOM   5474 O OE2   . GLU B 1 195 ? -17.712 32.569  8.913  1.00 87.07  ? 174  GLU B OE2   1 ? 
ATOM   5475 N N     . ASN B 1 196 ? -22.031 34.714  11.926 1.00 43.37  ? 175  ASN B N     1 ? 
ATOM   5476 C CA    . ASN B 1 196 ? -22.077 35.976  12.656 1.00 41.37  ? 175  ASN B CA    1 ? 
ATOM   5477 C C     . ASN B 1 196 ? -23.444 36.161  13.310 1.00 37.60  ? 175  ASN B C     1 ? 
ATOM   5478 O O     . ASN B 1 196 ? -24.388 36.571  12.639 1.00 36.77  ? 175  ASN B O     1 ? 
ATOM   5479 C CB    . ASN B 1 196 ? -21.735 37.153  11.753 1.00 36.07  ? 175  ASN B CB    1 ? 
ATOM   5480 C CG    . ASN B 1 196 ? -21.704 38.462  12.502 1.00 38.94  ? 175  ASN B CG    1 ? 
ATOM   5481 O OD1   . ASN B 1 196 ? -21.776 38.485  13.739 1.00 36.57  ? 175  ASN B OD1   1 ? 
ATOM   5482 N ND2   . ASN B 1 196 ? -21.558 39.553  11.767 1.00 37.80  ? 175  ASN B ND2   1 ? 
ATOM   5483 N N     . PRO B 1 197 ? -23.586 35.930  14.635 1.00 41.02  ? 176  PRO B N     1 ? 
ATOM   5484 C CA    . PRO B 1 197 ? -24.879 36.100  15.310 1.00 39.65  ? 176  PRO B CA    1 ? 
ATOM   5485 C C     . PRO B 1 197 ? -25.423 37.526  15.358 1.00 36.42  ? 176  PRO B C     1 ? 
ATOM   5486 O O     . PRO B 1 197 ? -26.628 37.712  15.513 1.00 35.96  ? 176  PRO B O     1 ? 
ATOM   5487 C CB    . PRO B 1 197 ? -24.670 35.533  16.737 1.00 41.44  ? 176  PRO B CB    1 ? 
ATOM   5488 C CG    . PRO B 1 197 ? -23.175 35.409  16.924 1.00 46.44  ? 176  PRO B CG    1 ? 
ATOM   5489 C CD    . PRO B 1 197 ? -22.541 35.425  15.535 1.00 45.43  ? 176  PRO B CD    1 ? 
ATOM   5490 N N     . TYR B 1 198 ? -24.554 38.535  15.202 1.00 34.37  ? 177  TYR B N     1 ? 
ATOM   5491 C CA    . TYR B 1 198 ? -24.974 39.921  15.304 1.00 31.03  ? 177  TYR B CA    1 ? 
ATOM   5492 C C     . TYR B 1 198 ? -25.398 40.411  13.928 1.00 33.53  ? 177  TYR B C     1 ? 
ATOM   5493 O O     . TYR B 1 198 ? -24.762 41.307  13.371 1.00 36.65  ? 177  TYR B O     1 ? 
ATOM   5494 C CB    . TYR B 1 198 ? -23.866 40.784  15.923 1.00 33.04  ? 177  TYR B CB    1 ? 
ATOM   5495 C CG    . TYR B 1 198 ? -23.437 40.223  17.267 1.00 33.06  ? 177  TYR B CG    1 ? 
ATOM   5496 C CD1   . TYR B 1 198 ? -24.167 40.503  18.413 1.00 34.29  ? 177  TYR B CD1   1 ? 
ATOM   5497 C CD2   . TYR B 1 198 ? -22.350 39.361  17.376 1.00 32.85  ? 177  TYR B CD2   1 ? 
ATOM   5498 C CE1   . TYR B 1 198 ? -23.818 39.958  19.640 1.00 37.76  ? 177  TYR B CE1   1 ? 
ATOM   5499 C CE2   . TYR B 1 198 ? -21.999 38.799  18.593 1.00 35.51  ? 177  TYR B CE2   1 ? 
ATOM   5500 C CZ    . TYR B 1 198 ? -22.735 39.105  19.727 1.00 37.98  ? 177  TYR B CZ    1 ? 
ATOM   5501 O OH    . TYR B 1 198 ? -22.418 38.595  20.944 1.00 39.01  ? 177  TYR B OH    1 ? 
ATOM   5502 N N     . SER B 1 199 ? -26.482 39.826  13.405 1.00 30.20  ? 178  SER B N     1 ? 
ATOM   5503 C CA    . SER B 1 199 ? -26.951 40.073  12.052 1.00 29.50  ? 178  SER B CA    1 ? 
ATOM   5504 C C     . SER B 1 199 ? -28.467 40.214  12.038 1.00 33.72  ? 178  SER B C     1 ? 
ATOM   5505 O O     . SER B 1 199 ? -29.170 39.754  12.955 1.00 32.52  ? 178  SER B O     1 ? 
ATOM   5506 C CB    . SER B 1 199 ? -26.548 38.957  11.093 1.00 34.95  ? 178  SER B CB    1 ? 
ATOM   5507 O OG    . SER B 1 199 ? -25.184 38.569  11.237 1.00 31.62  ? 178  SER B OG    1 ? 
ATOM   5508 N N     . ILE B 1 200 ? -28.947 40.805  10.943 1.00 32.06  ? 179  ILE B N     1 ? 
ATOM   5509 C CA    . ILE B 1 200 ? -30.358 40.910  10.633 1.00 31.50  ? 179  ILE B CA    1 ? 
ATOM   5510 C C     . ILE B 1 200 ? -30.618 40.090  9.378  1.00 37.61  ? 179  ILE B C     1 ? 
ATOM   5511 O O     . ILE B 1 200 ? -29.820 40.103  8.427  1.00 34.82  ? 179  ILE B O     1 ? 
ATOM   5512 C CB    . ILE B 1 200 ? -30.806 42.372  10.467 1.00 34.60  ? 179  ILE B CB    1 ? 
ATOM   5513 C CG1   . ILE B 1 200 ? -32.321 42.472  10.351 1.00 33.23  ? 179  ILE B CG1   1 ? 
ATOM   5514 C CG2   . ILE B 1 200 ? -30.112 43.057  9.275  1.00 37.37  ? 179  ILE B CG2   1 ? 
ATOM   5515 C CD1   . ILE B 1 200 ? -32.861 43.877  10.549 1.00 34.42  ? 179  ILE B CD1   1 ? 
ATOM   5516 N N     . ASP B 1 201 ? -31.735 39.355  9.420  1.00 33.80  ? 180  ASP B N     1 ? 
ATOM   5517 C CA    . ASP B 1 201 ? -32.163 38.577  8.280  1.00 33.09  ? 180  ASP B CA    1 ? 
ATOM   5518 C C     . ASP B 1 201 ? -33.688 38.537  8.240  1.00 32.25  ? 180  ASP B C     1 ? 
ATOM   5519 O O     . ASP B 1 201 ? -34.377 38.853  9.209  1.00 30.49  ? 180  ASP B O     1 ? 
ATOM   5520 C CB    . ASP B 1 201 ? -31.542 37.189  8.329  1.00 33.34  ? 180  ASP B CB    1 ? 
ATOM   5521 C CG    . ASP B 1 201 ? -31.322 36.525  6.985  1.00 35.37  ? 180  ASP B CG    1 ? 
ATOM   5522 O OD1   . ASP B 1 201 ? -31.669 37.175  5.966  1.00 34.32  ? 180  ASP B OD1   1 ? 
ATOM   5523 O OD2   . ASP B 1 201 ? -30.829 35.370  6.987  1.00 32.07  ? 180  ASP B OD2   1 ? 
ATOM   5524 N N     . ILE B 1 202 ? -34.189 38.143  7.079  1.00 28.19  ? 181  ILE B N     1 ? 
ATOM   5525 C CA    . ILE B 1 202 ? -35.538 37.654  6.912  1.00 30.30  ? 181  ILE B CA    1 ? 
ATOM   5526 C C     . ILE B 1 202 ? -35.693 36.391  7.759  1.00 28.82  ? 181  ILE B C     1 ? 
ATOM   5527 O O     . ILE B 1 202 ? -34.870 35.488  7.673  1.00 25.58  ? 181  ILE B O     1 ? 
ATOM   5528 C CB    . ILE B 1 202 ? -35.828 37.353  5.432  1.00 32.24  ? 181  ILE B CB    1 ? 
ATOM   5529 C CG1   . ILE B 1 202 ? -35.466 38.523  4.494  1.00 32.20  ? 181  ILE B CG1   1 ? 
ATOM   5530 C CG2   . ILE B 1 202 ? -37.290 36.957  5.271  1.00 32.81  ? 181  ILE B CG2   1 ? 
ATOM   5531 C CD1   . ILE B 1 202 ? -36.257 39.794  4.738  1.00 34.53  ? 181  ILE B CD1   1 ? 
ATOM   5532 N N     . MET B 1 203 ? -36.770 36.310  8.552  1.00 28.38  ? 182  MET B N     1 ? 
ATOM   5533 C CA    . MET B 1 203 ? -36.989 35.125  9.365  1.00 26.79  ? 182  MET B CA    1 ? 
ATOM   5534 C C     . MET B 1 203 ? -37.562 34.018  8.498  1.00 24.42  ? 182  MET B C     1 ? 
ATOM   5535 O O     . MET B 1 203 ? -38.491 34.245  7.735  1.00 31.24  ? 182  MET B O     1 ? 
ATOM   5536 C CB    . MET B 1 203 ? -37.948 35.381  10.542 1.00 26.49  ? 182  MET B CB    1 ? 
ATOM   5537 C CG    . MET B 1 203 ? -37.424 36.412  11.511 1.00 26.83  ? 182  MET B CG    1 ? 
ATOM   5538 S SD    . MET B 1 203 ? -38.473 36.611  12.971 1.00 25.52  ? 182  MET B SD    1 ? 
ATOM   5539 C CE    . MET B 1 203 ? -39.757 37.657  12.317 1.00 25.80  ? 182  MET B CE    1 ? 
ATOM   5540 N N     . GLN B 1 204 ? -37.024 32.812  8.677  1.00 25.22  ? 183  GLN B N     1 ? 
ATOM   5541 C CA    . GLN B 1 204 ? -37.609 31.612  8.107  1.00 25.70  ? 183  GLN B CA    1 ? 
ATOM   5542 C C     . GLN B 1 204 ? -38.674 31.061  9.050  1.00 24.87  ? 183  GLN B C     1 ? 
ATOM   5543 O O     . GLN B 1 204 ? -38.604 31.273  10.250 1.00 24.39  ? 183  GLN B O     1 ? 
ATOM   5544 C CB    . GLN B 1 204 ? -36.526 30.566  7.843  1.00 26.53  ? 183  GLN B CB    1 ? 
ATOM   5545 C CG    . GLN B 1 204 ? -35.449 31.054  6.875  1.00 26.46  ? 183  GLN B CG    1 ? 
ATOM   5546 C CD    . GLN B 1 204 ? -34.804 29.916  6.115  1.00 29.63  ? 183  GLN B CD    1 ? 
ATOM   5547 O OE1   . GLN B 1 204 ? -34.260 28.976  6.710  1.00 29.06  ? 183  GLN B OE1   1 ? 
ATOM   5548 N NE2   . GLN B 1 204 ? -34.871 29.994  4.790  1.00 28.40  ? 183  GLN B NE2   1 ? 
ATOM   5549 N N     . LYS B 1 205 ? -39.653 30.352  8.468  1.00 25.57  ? 184  LYS B N     1 ? 
ATOM   5550 C CA    . LYS B 1 205 ? -40.808 29.854  9.183  1.00 23.89  ? 184  LYS B CA    1 ? 
ATOM   5551 C C     . LYS B 1 205 ? -41.146 28.447  8.707  1.00 27.56  ? 184  LYS B C     1 ? 
ATOM   5552 O O     . LYS B 1 205 ? -40.737 28.060  7.599  1.00 25.45  ? 184  LYS B O     1 ? 
ATOM   5553 C CB    . LYS B 1 205 ? -41.971 30.813  8.898  1.00 23.79  ? 184  LYS B CB    1 ? 
ATOM   5554 C CG    . LYS B 1 205 ? -41.821 32.214  9.502  1.00 23.10  ? 184  LYS B CG    1 ? 
ATOM   5555 C CD    . LYS B 1 205 ? -43.063 33.103  9.444  1.00 23.97  ? 184  LYS B CD    1 ? 
ATOM   5556 C CE    . LYS B 1 205 ? -43.763 33.103  8.113  1.00 22.65  ? 184  LYS B CE    1 ? 
ATOM   5557 N NZ    . LYS B 1 205 ? -44.692 34.248  8.056  1.00 22.27  ? 184  LYS B NZ    1 ? 
ATOM   5558 N N     . ILE B 1 206 ? -41.951 27.747  9.528  1.00 24.95  ? 185  ILE B N     1 ? 
ATOM   5559 C CA    . ILE B 1 206 ? -42.378 26.375  9.285  1.00 25.62  ? 185  ILE B CA    1 ? 
ATOM   5560 C C     . ILE B 1 206 ? -43.578 26.386  8.347  1.00 26.92  ? 185  ILE B C     1 ? 
ATOM   5561 O O     . ILE B 1 206 ? -44.649 25.875  8.677  1.00 26.55  ? 185  ILE B O     1 ? 
ATOM   5562 C CB    . ILE B 1 206 ? -42.691 25.659  10.613 1.00 25.66  ? 185  ILE B CB    1 ? 
ATOM   5563 C CG1   . ILE B 1 206 ? -43.678 26.457  11.479 1.00 23.82  ? 185  ILE B CG1   1 ? 
ATOM   5564 C CG2   . ILE B 1 206 ? -41.405 25.365  11.384 1.00 24.04  ? 185  ILE B CG2   1 ? 
ATOM   5565 C CD1   . ILE B 1 206 ? -44.420 25.589  12.488 1.00 24.63  ? 185  ILE B CD1   1 ? 
ATOM   5566 N N     . TYR B 1 207 ? -43.391 26.946  7.145  1.00 26.99  ? 186  TYR B N     1 ? 
ATOM   5567 C CA    . TYR B 1 207 ? -44.413 26.935  6.115  1.00 27.30  ? 186  TYR B CA    1 ? 
ATOM   5568 C C     . TYR B 1 207 ? -43.818 26.327  4.839  1.00 30.83  ? 186  TYR B C     1 ? 
ATOM   5569 O O     . TYR B 1 207 ? -42.624 26.457  4.557  1.00 30.94  ? 186  TYR B O     1 ? 
ATOM   5570 C CB    . TYR B 1 207 ? -44.979 28.339  5.842  1.00 30.38  ? 186  TYR B CB    1 ? 
ATOM   5571 C CG    . TYR B 1 207 ? -45.762 28.900  7.024  1.00 29.45  ? 186  TYR B CG    1 ? 
ATOM   5572 C CD1   . TYR B 1 207 ? -45.097 29.367  8.155  1.00 30.73  ? 186  TYR B CD1   1 ? 
ATOM   5573 C CD2   . TYR B 1 207 ? -47.149 28.887  7.058  1.00 25.90  ? 186  TYR B CD2   1 ? 
ATOM   5574 C CE1   . TYR B 1 207 ? -45.794 29.844  9.257  1.00 25.87  ? 186  TYR B CE1   1 ? 
ATOM   5575 C CE2   . TYR B 1 207 ? -47.854 29.344  8.162  1.00 25.71  ? 186  TYR B CE2   1 ? 
ATOM   5576 C CZ    . TYR B 1 207 ? -47.175 29.825  9.271  1.00 26.58  ? 186  TYR B CZ    1 ? 
ATOM   5577 O OH    . TYR B 1 207 ? -47.858 30.296  10.379 1.00 28.17  ? 186  TYR B OH    1 ? 
ATOM   5578 N N     . GLU B 1 208 ? -44.708 25.689  4.078  1.00 34.01  ? 187  GLU B N     1 ? 
ATOM   5579 C CA    . GLU B 1 208 ? -44.432 25.112  2.774  1.00 36.08  ? 187  GLU B CA    1 ? 
ATOM   5580 C C     . GLU B 1 208 ? -45.618 25.454  1.889  1.00 33.40  ? 187  GLU B C     1 ? 
ATOM   5581 O O     . GLU B 1 208 ? -46.757 25.162  2.250  1.00 30.82  ? 187  GLU B O     1 ? 
ATOM   5582 C CB    . GLU B 1 208 ? -44.318 23.593  2.929  1.00 42.02  ? 187  GLU B CB    1 ? 
ATOM   5583 C CG    . GLU B 1 208 ? -44.080 22.828  1.636  1.00 47.60  ? 187  GLU B CG    1 ? 
ATOM   5584 C CD    . GLU B 1 208 ? -43.397 21.507  1.943  1.00 47.61  ? 187  GLU B CD    1 ? 
ATOM   5585 O OE1   . GLU B 1 208 ? -42.196 21.463  1.610  1.00 51.53  ? 187  GLU B OE1   1 ? 
ATOM   5586 O OE2   . GLU B 1 208 ? -44.031 20.563  2.485  1.00 43.38  ? 187  GLU B OE2   1 ? 
ATOM   5587 N N     . ASN B 1 209 ? -45.351 26.081  0.742  1.00 36.29  ? 188  ASN B N     1 ? 
ATOM   5588 C CA    . ASN B 1 209 ? -46.404 26.561  -0.131 1.00 37.70  ? 188  ASN B CA    1 ? 
ATOM   5589 C C     . ASN B 1 209 ? -47.420 27.374  0.672  1.00 35.62  ? 188  ASN B C     1 ? 
ATOM   5590 O O     . ASN B 1 209 ? -48.613 27.097  0.610  1.00 39.03  ? 188  ASN B O     1 ? 
ATOM   5591 C CB    . ASN B 1 209 ? -47.090 25.422  -0.879 1.00 41.38  ? 188  ASN B CB    1 ? 
ATOM   5592 C CG    . ASN B 1 209 ? -47.975 25.947  -1.992 1.00 46.57  ? 188  ASN B CG    1 ? 
ATOM   5593 O OD1   . ASN B 1 209 ? -47.675 26.992  -2.592 1.00 48.61  ? 188  ASN B OD1   1 ? 
ATOM   5594 N ND2   . ASN B 1 209 ? -49.098 25.289  -2.237 1.00 47.79  ? 188  ASN B ND2   1 ? 
ATOM   5595 N N     . ASN B 1 210 ? -46.931 28.346  1.451  1.00 38.63  ? 189  ASN B N     1 ? 
ATOM   5596 C CA    . ASN B 1 210 ? -47.776 29.304  2.143  1.00 39.72  ? 189  ASN B CA    1 ? 
ATOM   5597 C C     . ASN B 1 210 ? -48.741 28.615  3.123  1.00 34.37  ? 189  ASN B C     1 ? 
ATOM   5598 O O     . ASN B 1 210 ? -49.817 29.158  3.404  1.00 31.71  ? 189  ASN B O     1 ? 
ATOM   5599 C CB    . ASN B 1 210 ? -48.545 30.121  1.108  1.00 39.01  ? 189  ASN B CB    1 ? 
ATOM   5600 C CG    . ASN B 1 210 ? -48.776 31.548  1.524  1.00 44.09  ? 189  ASN B CG    1 ? 
ATOM   5601 O OD1   . ASN B 1 210 ? -48.079 32.087  2.389  1.00 55.09  ? 189  ASN B OD1   1 ? 
ATOM   5602 N ND2   . ASN B 1 210 ? -49.720 32.195  0.864  1.00 52.74  ? 189  ASN B ND2   1 ? 
ATOM   5603 N N     . THR B 1 211 ? -48.357 27.437  3.633  1.00 29.69  ? 190  THR B N     1 ? 
ATOM   5604 C CA    . THR B 1 211 ? -49.218 26.631  4.495  1.00 32.69  ? 190  THR B CA    1 ? 
ATOM   5605 C C     . THR B 1 211 ? -48.362 26.033  5.604  1.00 28.58  ? 190  THR B C     1 ? 
ATOM   5606 O O     . THR B 1 211 ? -47.325 25.436  5.319  1.00 25.12  ? 190  THR B O     1 ? 
ATOM   5607 C CB    . THR B 1 211 ? -49.905 25.495  3.727  1.00 36.34  ? 190  THR B CB    1 ? 
ATOM   5608 O OG1   . THR B 1 211 ? -50.529 25.982  2.545  1.00 36.12  ? 190  THR B OG1   1 ? 
ATOM   5609 C CG2   . THR B 1 211 ? -51.006 24.827  4.533  1.00 36.83  ? 190  THR B CG2   1 ? 
ATOM   5610 N N     . ARG B 1 212 ? -48.845 26.132  6.856  1.00 25.15  ? 191  ARG B N     1 ? 
ATOM   5611 C CA    . ARG B 1 212 ? -48.063 25.706  8.000  1.00 23.89  ? 191  ARG B CA    1 ? 
ATOM   5612 C C     . ARG B 1 212 ? -47.825 24.203  7.888  1.00 21.96  ? 191  ARG B C     1 ? 
ATOM   5613 O O     . ARG B 1 212 ? -48.746 23.441  7.601  1.00 25.80  ? 191  ARG B O     1 ? 
ATOM   5614 C CB    . ARG B 1 212 ? -48.745 26.043  9.338  1.00 24.38  ? 191  ARG B CB    1 ? 
ATOM   5615 C CG    . ARG B 1 212 ? -47.915 25.703  10.574 1.00 24.03  ? 191  ARG B CG    1 ? 
ATOM   5616 C CD    . ARG B 1 212 ? -48.779 25.618  11.845 1.00 20.59  ? 191  ARG B CD    1 ? 
ATOM   5617 N NE    . ARG B 1 212 ? -49.540 26.839  12.099 1.00 20.41  ? 191  ARG B NE    1 ? 
ATOM   5618 C CZ    . ARG B 1 212 ? -49.030 27.941  12.664 1.00 21.61  ? 191  ARG B CZ    1 ? 
ATOM   5619 N NH1   . ARG B 1 212 ? -47.806 27.949  13.158 1.00 24.28  ? 191  ARG B NH1   1 ? 
ATOM   5620 N NH2   . ARG B 1 212 ? -49.791 28.996  12.827 1.00 24.18  ? 191  ARG B NH2   1 ? 
ATOM   5621 N N     . ARG B 1 213 ? -46.587 23.795  8.138  1.00 22.50  ? 192  ARG B N     1 ? 
ATOM   5622 C CA    . ARG B 1 213 ? -46.253 22.396  8.303  1.00 25.11  ? 192  ARG B CA    1 ? 
ATOM   5623 C C     . ARG B 1 213 ? -45.454 22.225  9.582  1.00 25.05  ? 192  ARG B C     1 ? 
ATOM   5624 O O     . ARG B 1 213 ? -44.300 22.642  9.641  1.00 22.61  ? 192  ARG B O     1 ? 
ATOM   5625 C CB    . ARG B 1 213 ? -45.354 21.897  7.174  1.00 31.64  ? 192  ARG B CB    1 ? 
ATOM   5626 C CG    . ARG B 1 213 ? -46.049 21.617  5.861  1.00 40.76  ? 192  ARG B CG    1 ? 
ATOM   5627 C CD    . ARG B 1 213 ? -46.257 20.123  5.727  1.00 45.48  ? 192  ARG B CD    1 ? 
ATOM   5628 N NE    . ARG B 1 213 ? -45.021 19.323  5.717  1.00 44.14  ? 192  ARG B NE    1 ? 
ATOM   5629 C CZ    . ARG B 1 213 ? -45.057 17.994  5.747  1.00 40.63  ? 192  ARG B CZ    1 ? 
ATOM   5630 N NH1   . ARG B 1 213 ? -46.230 17.375  5.779  1.00 51.01  ? 192  ARG B NH1   1 ? 
ATOM   5631 N NH2   . ARG B 1 213 ? -43.954 17.276  5.786  1.00 43.25  ? 192  ARG B NH2   1 ? 
ATOM   5632 N N     . THR B 1 214 ? -46.115 21.645  10.598 1.00 22.95  ? 193  THR B N     1 ? 
ATOM   5633 C CA    . THR B 1 214 ? -45.575 21.601  11.942 1.00 21.96  ? 193  THR B CA    1 ? 
ATOM   5634 C C     . THR B 1 214 ? -44.537 20.500  11.994 1.00 22.92  ? 193  THR B C     1 ? 
ATOM   5635 O O     . THR B 1 214 ? -44.557 19.610  11.154 1.00 23.92  ? 193  THR B O     1 ? 
ATOM   5636 C CB    . THR B 1 214 ? -46.661 21.349  12.990 1.00 22.14  ? 193  THR B CB    1 ? 
ATOM   5637 O OG1   . THR B 1 214 ? -47.237 20.069  12.724 1.00 20.10  ? 193  THR B OG1   1 ? 
ATOM   5638 C CG2   . THR B 1 214 ? -47.752 22.407  13.014 1.00 23.22  ? 193  THR B CG2   1 ? 
ATOM   5639 N N     . PRO B 1 215 ? -43.682 20.469  13.038 1.00 21.19  ? 194  PRO B N     1 ? 
ATOM   5640 C CA    . PRO B 1 215 ? -42.924 19.264  13.342 1.00 21.71  ? 194  PRO B CA    1 ? 
ATOM   5641 C C     . PRO B 1 215 ? -43.783 18.001  13.432 1.00 25.07  ? 194  PRO B C     1 ? 
ATOM   5642 O O     . PRO B 1 215 ? -43.407 16.955  12.895 1.00 23.44  ? 194  PRO B O     1 ? 
ATOM   5643 C CB    . PRO B 1 215 ? -42.226 19.636  14.664 1.00 20.91  ? 194  PRO B CB    1 ? 
ATOM   5644 C CG    . PRO B 1 215 ? -42.076 21.139  14.588 1.00 21.48  ? 194  PRO B CG    1 ? 
ATOM   5645 C CD    . PRO B 1 215 ? -43.336 21.615  13.902 1.00 22.63  ? 194  PRO B CD    1 ? 
ATOM   5646 N N     . ALA B 1 216 ? -44.966 18.085  14.067 1.00 23.65  ? 195  ALA B N     1 ? 
ATOM   5647 C CA    . ALA B 1 216 ? -45.827 16.913  14.142 1.00 25.31  ? 195  ALA B CA    1 ? 
ATOM   5648 C C     . ALA B 1 216 ? -46.271 16.444  12.736 1.00 24.28  ? 195  ALA B C     1 ? 
ATOM   5649 O O     . ALA B 1 216 ? -46.323 15.239  12.493 1.00 25.08  ? 195  ALA B O     1 ? 
ATOM   5650 C CB    . ALA B 1 216 ? -47.000 17.184  15.038 1.00 24.87  ? 195  ALA B CB    1 ? 
ATOM   5651 N N     . ASP B 1 217 ? -46.621 17.383  11.837 1.00 23.12  ? 196  ASP B N     1 ? 
ATOM   5652 C CA    . ASP B 1 217 ? -46.970 17.023  10.471 1.00 26.01  ? 196  ASP B CA    1 ? 
ATOM   5653 C C     . ASP B 1 217 ? -45.801 16.289  9.831  1.00 28.43  ? 196  ASP B C     1 ? 
ATOM   5654 O O     . ASP B 1 217 ? -46.014 15.344  9.063  1.00 29.11  ? 196  ASP B O     1 ? 
ATOM   5655 C CB    . ASP B 1 217 ? -47.297 18.216  9.589  1.00 26.84  ? 196  ASP B CB    1 ? 
ATOM   5656 C CG    . ASP B 1 217 ? -48.572 18.986  9.892  1.00 29.03  ? 196  ASP B CG    1 ? 
ATOM   5657 O OD1   . ASP B 1 217 ? -49.621 18.341  10.130 1.00 29.62  ? 196  ASP B OD1   1 ? 
ATOM   5658 O OD2   . ASP B 1 217 ? -48.522 20.232  9.852  1.00 29.83  ? 196  ASP B OD2   1 ? 
ATOM   5659 N N     . SER B 1 218 ? -44.581 16.731  10.181 1.00 27.63  ? 197  SER B N     1 ? 
ATOM   5660 C CA    . SER B 1 218 ? -43.357 16.350  9.493  1.00 34.26  ? 197  SER B CA    1 ? 
ATOM   5661 C C     . SER B 1 218 ? -42.838 15.012  10.006 1.00 31.11  ? 197  SER B C     1 ? 
ATOM   5662 O O     . SER B 1 218 ? -42.244 14.245  9.249  1.00 27.10  ? 197  SER B O     1 ? 
ATOM   5663 C CB    . SER B 1 218 ? -42.301 17.438  9.625  1.00 34.89  ? 197  SER B CB    1 ? 
ATOM   5664 O OG    . SER B 1 218 ? -42.780 18.658  9.068  1.00 40.47  ? 197  SER B OG    1 ? 
ATOM   5665 N N     . TYR B 1 219 ? -43.067 14.738  11.303 1.00 27.54  ? 198  TYR B N     1 ? 
ATOM   5666 C CA    . TYR B 1 219 ? -42.544 13.534  11.939 1.00 24.83  ? 198  TYR B CA    1 ? 
ATOM   5667 C C     . TYR B 1 219 ? -43.609 12.437  12.061 1.00 26.11  ? 198  TYR B C     1 ? 
ATOM   5668 O O     . TYR B 1 219 ? -43.253 11.263  12.167 1.00 29.03  ? 198  TYR B O     1 ? 
ATOM   5669 C CB    . TYR B 1 219 ? -41.979 13.825  13.329 1.00 25.51  ? 198  TYR B CB    1 ? 
ATOM   5670 C CG    . TYR B 1 219 ? -40.611 14.501  13.362 1.00 26.01  ? 198  TYR B CG    1 ? 
ATOM   5671 C CD1   . TYR B 1 219 ? -40.487 15.881  13.193 1.00 23.75  ? 198  TYR B CD1   1 ? 
ATOM   5672 C CD2   . TYR B 1 219 ? -39.458 13.777  13.619 1.00 25.37  ? 198  TYR B CD2   1 ? 
ATOM   5673 C CE1   . TYR B 1 219 ? -39.261 16.506  13.253 1.00 25.07  ? 198  TYR B CE1   1 ? 
ATOM   5674 C CE2   . TYR B 1 219 ? -38.221 14.396  13.698 1.00 24.98  ? 198  TYR B CE2   1 ? 
ATOM   5675 C CZ    . TYR B 1 219 ? -38.118 15.764  13.500 1.00 24.35  ? 198  TYR B CZ    1 ? 
ATOM   5676 O OH    . TYR B 1 219 ? -36.904 16.405  13.557 1.00 25.18  ? 198  TYR B OH    1 ? 
ATOM   5677 N N     . LEU B 1 220 ? -44.895 12.806  12.084 1.00 25.31  ? 199  LEU B N     1 ? 
ATOM   5678 C CA    . LEU B 1 220 ? -45.965 11.827  12.164 1.00 26.13  ? 199  LEU B CA    1 ? 
ATOM   5679 C C     . LEU B 1 220 ? -46.692 11.815  10.826 1.00 27.48  ? 199  LEU B C     1 ? 
ATOM   5680 O O     . LEU B 1 220 ? -47.861 12.154  10.763 1.00 28.10  ? 199  LEU B O     1 ? 
ATOM   5681 C CB    . LEU B 1 220 ? -46.927 12.134  13.317 1.00 25.29  ? 199  LEU B CB    1 ? 
ATOM   5682 C CG    . LEU B 1 220 ? -46.317 12.183  14.718 1.00 26.48  ? 199  LEU B CG    1 ? 
ATOM   5683 C CD1   . LEU B 1 220 ? -47.386 12.524  15.740 1.00 27.35  ? 199  LEU B CD1   1 ? 
ATOM   5684 C CD2   . LEU B 1 220 ? -45.652 10.880  15.081 1.00 28.80  ? 199  LEU B CD2   1 ? 
ATOM   5685 N N     . THR B 1 221 ? -45.969 11.437  9.768  1.00 33.14  ? 200  THR B N     1 ? 
ATOM   5686 C CA    . THR B 1 221 ? -46.525 11.323  8.427  1.00 36.41  ? 200  THR B CA    1 ? 
ATOM   5687 C C     . THR B 1 221 ? -47.414 10.091  8.328  1.00 32.46  ? 200  THR B C     1 ? 
ATOM   5688 O O     . THR B 1 221 ? -47.445 9.263   9.234  1.00 27.63  ? 200  THR B O     1 ? 
ATOM   5689 C CB    . THR B 1 221 ? -45.401 11.236  7.397  1.00 37.55  ? 200  THR B CB    1 ? 
ATOM   5690 O OG1   . THR B 1 221 ? -44.647 10.121  7.862  1.00 37.67  ? 200  THR B OG1   1 ? 
ATOM   5691 C CG2   . THR B 1 221 ? -44.603 12.525  7.308  1.00 38.13  ? 200  THR B CG2   1 ? 
ATOM   5692 N N     . GLU B 1 222 ? -48.137 9.973   7.209  1.00 33.60  ? 201  GLU B N     1 ? 
ATOM   5693 C CA    . GLU B 1 222 ? -48.943 8.785   6.948  1.00 38.17  ? 201  GLU B CA    1 ? 
ATOM   5694 C C     . GLU B 1 222 ? -48.109 7.515   7.172  1.00 32.49  ? 201  GLU B C     1 ? 
ATOM   5695 O O     . GLU B 1 222 ? -48.543 6.566   7.822  1.00 32.62  ? 201  GLU B O     1 ? 
ATOM   5696 C CB    . GLU B 1 222 ? -49.522 8.928   5.539  1.00 45.15  ? 201  GLU B CB    1 ? 
ATOM   5697 C CG    . GLU B 1 222 ? -50.375 7.752   5.072  1.00 56.19  ? 201  GLU B CG    1 ? 
ATOM   5698 C CD    . GLU B 1 222 ? -50.840 7.903   3.631  1.00 65.86  ? 201  GLU B CD    1 ? 
ATOM   5699 O OE1   . GLU B 1 222 ? -52.074 8.022   3.418  1.00 74.34  ? 201  GLU B OE1   1 ? 
ATOM   5700 O OE2   . GLU B 1 222 ? -49.966 7.923   2.728  1.00 65.50  ? 201  GLU B OE2   1 ? 
ATOM   5701 N N     . ASP B 1 223 ? -46.881 7.500   6.669  1.00 34.41  ? 202  ASP B N     1 ? 
ATOM   5702 C CA    . ASP B 1 223 ? -46.028 6.328   6.785  1.00 36.27  ? 202  ASP B CA    1 ? 
ATOM   5703 C C     . ASP B 1 223 ? -45.743 5.983   8.240  1.00 35.86  ? 202  ASP B C     1 ? 
ATOM   5704 O O     . ASP B 1 223 ? -45.740 4.813   8.625  1.00 31.69  ? 202  ASP B O     1 ? 
ATOM   5705 C CB    . ASP B 1 223 ? -44.709 6.505   6.051  1.00 45.78  ? 202  ASP B CB    1 ? 
ATOM   5706 C CG    . ASP B 1 223 ? -44.713 5.978   4.626  1.00 53.43  ? 202  ASP B CG    1 ? 
ATOM   5707 O OD1   . ASP B 1 223 ? -45.780 5.487   4.181  1.00 57.29  ? 202  ASP B OD1   1 ? 
ATOM   5708 O OD2   . ASP B 1 223 ? -43.653 6.055   3.970  1.00 64.51  ? 202  ASP B OD2   1 ? 
ATOM   5709 N N     . VAL B 1 224 ? -45.485 7.009   9.059  1.00 33.17  ? 203  VAL B N     1 ? 
ATOM   5710 C CA    . VAL B 1 224 ? -45.093 6.773   10.440 1.00 27.69  ? 203  VAL B CA    1 ? 
ATOM   5711 C C     . VAL B 1 224 ? -46.312 6.265   11.197 1.00 26.45  ? 203  VAL B C     1 ? 
ATOM   5712 O O     . VAL B 1 224 ? -46.231 5.327   11.994 1.00 25.75  ? 203  VAL B O     1 ? 
ATOM   5713 C CB    . VAL B 1 224 ? -44.519 8.063   11.051 1.00 27.26  ? 203  VAL B CB    1 ? 
ATOM   5714 C CG1   . VAL B 1 224 ? -44.356 7.948   12.558 1.00 31.24  ? 203  VAL B CG1   1 ? 
ATOM   5715 C CG2   . VAL B 1 224 ? -43.215 8.453   10.394 1.00 27.47  ? 203  VAL B CG2   1 ? 
ATOM   5716 N N     . ARG B 1 225 ? -47.454 6.891   10.923 1.00 29.70  ? 204  ARG B N     1 ? 
ATOM   5717 C CA    . ARG B 1 225 ? -48.692 6.566   11.615 1.00 30.41  ? 204  ARG B CA    1 ? 
ATOM   5718 C C     . ARG B 1 225 ? -49.189 5.169   11.238 1.00 33.93  ? 204  ARG B C     1 ? 
ATOM   5719 O O     . ARG B 1 225 ? -49.959 4.574   11.992 1.00 29.56  ? 204  ARG B O     1 ? 
ATOM   5720 C CB    . ARG B 1 225 ? -49.739 7.612   11.238 1.00 32.68  ? 204  ARG B CB    1 ? 
ATOM   5721 C CG    . ARG B 1 225 ? -49.476 8.955   11.902 1.00 30.88  ? 204  ARG B CG    1 ? 
ATOM   5722 C CD    . ARG B 1 225 ? -50.454 9.981   11.367 1.00 32.89  ? 204  ARG B CD    1 ? 
ATOM   5723 N NE    . ARG B 1 225 ? -50.361 11.276  12.057 1.00 33.33  ? 204  ARG B NE    1 ? 
ATOM   5724 C CZ    . ARG B 1 225 ? -51.224 11.756  12.944 1.00 31.25  ? 204  ARG B CZ    1 ? 
ATOM   5725 N NH1   . ARG B 1 225 ? -52.231 11.032  13.371 1.00 30.71  ? 204  ARG B NH1   1 ? 
ATOM   5726 N NH2   . ARG B 1 225 ? -51.067 12.966  13.422 1.00 27.51  ? 204  ARG B NH2   1 ? 
ATOM   5727 N N     . ALA B 1 226 ? -48.771 4.666   10.062 1.00 33.12  ? 205  ALA B N     1 ? 
ATOM   5728 C CA    . ALA B 1 226 ? -49.173 3.346   9.594  1.00 36.35  ? 205  ALA B CA    1 ? 
ATOM   5729 C C     . ALA B 1 226 ? -48.373 2.261   10.315 1.00 35.48  ? 205  ALA B C     1 ? 
ATOM   5730 O O     . ALA B 1 226 ? -48.709 1.082   10.227 1.00 35.84  ? 205  ALA B O     1 ? 
ATOM   5731 C CB    . ALA B 1 226 ? -49.013 3.247   8.072  1.00 36.12  ? 205  ALA B CB    1 ? 
ATOM   5732 N N     . ARG B 1 227 ? -47.324 2.640   11.051 1.00 30.18  ? 206  ARG B N     1 ? 
ATOM   5733 C CA    . ARG B 1 227 ? -46.565 1.655   11.807 1.00 31.45  ? 206  ARG B CA    1 ? 
ATOM   5734 C C     . ARG B 1 227 ? -47.460 0.968   12.833 1.00 35.03  ? 206  ARG B C     1 ? 
ATOM   5735 O O     . ARG B 1 227 ? -48.216 1.623   13.553 1.00 35.03  ? 206  ARG B O     1 ? 
ATOM   5736 C CB    . ARG B 1 227 ? -45.361 2.283   12.503 1.00 31.21  ? 206  ARG B CB    1 ? 
ATOM   5737 C CG    . ARG B 1 227 ? -44.297 2.813   11.551 1.00 29.74  ? 206  ARG B CG    1 ? 
ATOM   5738 C CD    . ARG B 1 227 ? -43.294 3.644   12.306 1.00 31.83  ? 206  ARG B CD    1 ? 
ATOM   5739 N NE    . ARG B 1 227 ? -42.357 4.330   11.414 1.00 31.88  ? 206  ARG B NE    1 ? 
ATOM   5740 C CZ    . ARG B 1 227 ? -41.419 5.176   11.829 1.00 31.71  ? 206  ARG B CZ    1 ? 
ATOM   5741 N NH1   . ARG B 1 227 ? -41.394 5.589   13.093 1.00 28.17  ? 206  ARG B NH1   1 ? 
ATOM   5742 N NH2   . ARG B 1 227 ? -40.534 5.640   10.961 1.00 30.36  ? 206  ARG B NH2   1 ? 
ATOM   5743 N N     . GLU B 1 228 ? -47.338 -0.360  12.911 1.00 36.23  ? 207  GLU B N     1 ? 
ATOM   5744 C CA    . GLU B 1 228 ? -48.130 -1.153  13.830 1.00 36.36  ? 207  GLU B CA    1 ? 
ATOM   5745 C C     . GLU B 1 228 ? -47.712 -0.883  15.275 1.00 30.46  ? 207  GLU B C     1 ? 
ATOM   5746 O O     . GLU B 1 228 ? -48.472 -1.164  16.191 1.00 28.60  ? 207  GLU B O     1 ? 
ATOM   5747 C CB    . GLU B 1 228 ? -47.941 -2.652  13.588 1.00 43.16  ? 207  GLU B CB    1 ? 
ATOM   5748 C CG    . GLU B 1 228 ? -48.722 -3.167  12.385 1.00 56.29  ? 207  GLU B CG    1 ? 
ATOM   5749 C CD    . GLU B 1 228 ? -48.510 -4.646  12.095 1.00 66.42  ? 207  GLU B CD    1 ? 
ATOM   5750 O OE1   . GLU B 1 228 ? -49.035 -5.102  11.048 1.00 66.73  ? 207  GLU B OE1   1 ? 
ATOM   5751 O OE2   . GLU B 1 228 ? -47.827 -5.334  12.900 1.00 72.03  ? 207  GLU B OE2   1 ? 
ATOM   5752 N N     . ASN B 1 229 ? -46.500 -0.375  15.473 1.00 29.68  ? 208  ASN B N     1 ? 
ATOM   5753 C CA    . ASN B 1 229 ? -45.968 -0.214  16.822 1.00 32.13  ? 208  ASN B CA    1 ? 
ATOM   5754 C C     . ASN B 1 229 ? -46.164 1.215   17.350 1.00 29.75  ? 208  ASN B C     1 ? 
ATOM   5755 O O     . ASN B 1 229 ? -45.593 1.581   18.383 1.00 30.12  ? 208  ASN B O     1 ? 
ATOM   5756 C CB    . ASN B 1 229 ? -44.531 -0.710  16.878 1.00 30.88  ? 208  ASN B CB    1 ? 
ATOM   5757 C CG    . ASN B 1 229 ? -43.600 -0.006  15.914 1.00 32.92  ? 208  ASN B CG    1 ? 
ATOM   5758 O OD1   . ASN B 1 229 ? -43.943 0.245   14.754 1.00 32.47  ? 208  ASN B OD1   1 ? 
ATOM   5759 N ND2   . ASN B 1 229 ? -42.396 0.291   16.370 1.00 34.87  ? 208  ASN B ND2   1 ? 
ATOM   5760 N N     . LEU B 1 230 ? -46.997 2.004   16.669 1.00 30.02  ? 209  LEU B N     1 ? 
ATOM   5761 C CA    . LEU B 1 230 ? -47.329 3.353   17.105 1.00 28.82  ? 209  LEU B CA    1 ? 
ATOM   5762 C C     . LEU B 1 230 ? -48.846 3.471   17.212 1.00 30.54  ? 209  LEU B C     1 ? 
ATOM   5763 O O     . LEU B 1 230 ? -49.552 3.236   16.232 1.00 31.33  ? 209  LEU B O     1 ? 
ATOM   5764 C CB    . LEU B 1 230 ? -46.744 4.389   16.143 1.00 27.58  ? 209  LEU B CB    1 ? 
ATOM   5765 C CG    . LEU B 1 230 ? -47.126 5.850   16.415 1.00 29.89  ? 209  LEU B CG    1 ? 
ATOM   5766 C CD1   . LEU B 1 230 ? -46.688 6.285   17.807 1.00 28.38  ? 209  LEU B CD1   1 ? 
ATOM   5767 C CD2   . LEU B 1 230 ? -46.526 6.749   15.351 1.00 29.26  ? 209  LEU B CD2   1 ? 
ATOM   5768 N N     . THR B 1 231 ? -49.334 3.842   18.408 1.00 24.35  ? 210  THR B N     1 ? 
ATOM   5769 C CA    . THR B 1 231 ? -50.724 4.185   18.619 1.00 27.39  ? 210  THR B CA    1 ? 
ATOM   5770 C C     . THR B 1 231 ? -50.830 5.635   19.064 1.00 25.14  ? 210  THR B C     1 ? 
ATOM   5771 O O     . THR B 1 231 ? -50.155 6.030   20.007 1.00 24.78  ? 210  THR B O     1 ? 
ATOM   5772 C CB    . THR B 1 231 ? -51.324 3.277   19.688 1.00 28.15  ? 210  THR B CB    1 ? 
ATOM   5773 O OG1   . THR B 1 231 ? -51.138 1.974   19.160 1.00 26.76  ? 210  THR B OG1   1 ? 
ATOM   5774 C CG2   . THR B 1 231 ? -52.802 3.534   19.893 1.00 30.62  ? 210  THR B CG2   1 ? 
ATOM   5775 N N     . ILE B 1 232 ? -51.661 6.409   18.364 1.00 25.61  ? 211  ILE B N     1 ? 
ATOM   5776 C CA    . ILE B 1 232 ? -51.922 7.787   18.739 1.00 27.39  ? 211  ILE B CA    1 ? 
ATOM   5777 C C     . ILE B 1 232 ? -53.373 7.860   19.174 1.00 27.41  ? 211  ILE B C     1 ? 
ATOM   5778 O O     . ILE B 1 232 ? -54.250 7.461   18.413 1.00 27.50  ? 211  ILE B O     1 ? 
ATOM   5779 C CB    . ILE B 1 232 ? -51.670 8.725   17.549 1.00 27.98  ? 211  ILE B CB    1 ? 
ATOM   5780 C CG1   . ILE B 1 232 ? -50.247 8.584   17.028 1.00 25.86  ? 211  ILE B CG1   1 ? 
ATOM   5781 C CG2   . ILE B 1 232 ? -52.028 10.176  17.925 1.00 29.63  ? 211  ILE B CG2   1 ? 
ATOM   5782 C CD1   . ILE B 1 232 ? -49.978 9.361   15.755 1.00 27.24  ? 211  ILE B CD1   1 ? 
ATOM   5783 N N     . ILE B 1 233 ? -53.632 8.366   20.383 1.00 23.98  ? 212  ILE B N     1 ? 
ATOM   5784 C CA    . ILE B 1 233 ? -54.999 8.647   20.802 1.00 23.03  ? 212  ILE B CA    1 ? 
ATOM   5785 C C     . ILE B 1 233 ? -55.135 10.155  21.027 1.00 23.05  ? 212  ILE B C     1 ? 
ATOM   5786 O O     . ILE B 1 233 ? -54.435 10.719  21.885 1.00 19.88  ? 212  ILE B O     1 ? 
ATOM   5787 C CB    . ILE B 1 233 ? -55.389 7.843   22.055 1.00 22.68  ? 212  ILE B CB    1 ? 
ATOM   5788 C CG1   . ILE B 1 233 ? -55.053 6.356   21.929 1.00 26.18  ? 212  ILE B CG1   1 ? 
ATOM   5789 C CG2   . ILE B 1 233 ? -56.858 8.042   22.373 1.00 23.83  ? 212  ILE B CG2   1 ? 
ATOM   5790 C CD1   . ILE B 1 233 ? -55.369 5.542   23.172 1.00 26.00  ? 212  ILE B CD1   1 ? 
ATOM   5791 N N     . THR B 1 234 ? -56.072 10.778  20.301 1.00 21.83  ? 213  THR B N     1 ? 
ATOM   5792 C CA    . THR B 1 234 ? -56.434 12.179  20.546 1.00 22.87  ? 213  THR B CA    1 ? 
ATOM   5793 C C     . THR B 1 234 ? -57.663 12.233  21.453 1.00 22.72  ? 213  THR B C     1 ? 
ATOM   5794 O O     . THR B 1 234 ? -58.286 11.225  21.776 1.00 22.90  ? 213  THR B O     1 ? 
ATOM   5795 C CB    . THR B 1 234 ? -56.661 12.934  19.226 1.00 24.90  ? 213  THR B CB    1 ? 
ATOM   5796 O OG1   . THR B 1 234 ? -57.540 12.124  18.461 1.00 24.91  ? 213  THR B OG1   1 ? 
ATOM   5797 C CG2   . THR B 1 234 ? -55.385 13.211  18.447 1.00 25.60  ? 213  THR B CG2   1 ? 
ATOM   5798 N N     . HIS B 1 235 ? -57.985 13.436  21.919 1.00 22.32  ? 214  HIS B N     1 ? 
ATOM   5799 C CA    . HIS B 1 235 ? -58.993 13.632  22.942 1.00 21.74  ? 214  HIS B CA    1 ? 
ATOM   5800 C C     . HIS B 1 235 ? -58.764 12.720  24.138 1.00 23.13  ? 214  HIS B C     1 ? 
ATOM   5801 O O     . HIS B 1 235 ? -59.709 12.116  24.667 1.00 26.97  ? 214  HIS B O     1 ? 
ATOM   5802 C CB    . HIS B 1 235 ? -60.396 13.525  22.342 1.00 23.89  ? 214  HIS B CB    1 ? 
ATOM   5803 C CG    . HIS B 1 235 ? -60.633 14.552  21.282 1.00 22.40  ? 214  HIS B CG    1 ? 
ATOM   5804 N ND1   . HIS B 1 235 ? -61.042 15.835  21.573 1.00 23.04  ? 214  HIS B ND1   1 ? 
ATOM   5805 C CD2   . HIS B 1 235 ? -60.553 14.474  19.951 1.00 22.42  ? 214  HIS B CD2   1 ? 
ATOM   5806 C CE1   . HIS B 1 235 ? -61.183 16.506  20.435 1.00 24.58  ? 214  HIS B CE1   1 ? 
ATOM   5807 N NE2   . HIS B 1 235 ? -60.880 15.692  19.435 1.00 24.41  ? 214  HIS B NE2   1 ? 
ATOM   5808 N N     . ALA B 1 236 ? -57.497 12.649  24.552 1.00 18.85  ? 215  ALA B N     1 ? 
ATOM   5809 C CA    . ALA B 1 236 ? -57.042 11.872  25.683 1.00 18.16  ? 215  ALA B CA    1 ? 
ATOM   5810 C C     . ALA B 1 236 ? -56.338 12.790  26.681 1.00 20.68  ? 215  ALA B C     1 ? 
ATOM   5811 O O     . ALA B 1 236 ? -55.213 13.245  26.428 1.00 22.54  ? 215  ALA B O     1 ? 
ATOM   5812 C CB    . ALA B 1 236 ? -56.108 10.791  25.222 1.00 17.26  ? 215  ALA B CB    1 ? 
ATOM   5813 N N     . PHE B 1 237 ? -57.015 13.050  27.805 1.00 19.91  ? 216  PHE B N     1 ? 
ATOM   5814 C CA    . PHE B 1 237 ? -56.549 14.020  28.765 1.00 21.26  ? 216  PHE B CA    1 ? 
ATOM   5815 C C     . PHE B 1 237 ? -55.917 13.275  29.924 1.00 20.38  ? 216  PHE B C     1 ? 
ATOM   5816 O O     . PHE B 1 237 ? -56.612 12.559  30.632 1.00 20.31  ? 216  PHE B O     1 ? 
ATOM   5817 C CB    . PHE B 1 237 ? -57.723 14.869  29.249 1.00 20.75  ? 216  PHE B CB    1 ? 
ATOM   5818 C CG    . PHE B 1 237 ? -57.289 15.878  30.295 1.00 20.78  ? 216  PHE B CG    1 ? 
ATOM   5819 C CD1   . PHE B 1 237 ? -56.446 16.928  29.956 1.00 20.55  ? 216  PHE B CD1   1 ? 
ATOM   5820 C CD2   . PHE B 1 237 ? -57.713 15.765  31.608 1.00 19.48  ? 216  PHE B CD2   1 ? 
ATOM   5821 C CE1   . PHE B 1 237 ? -56.054 17.867  30.914 1.00 22.26  ? 216  PHE B CE1   1 ? 
ATOM   5822 C CE2   . PHE B 1 237 ? -57.327 16.708  32.555 1.00 21.30  ? 216  PHE B CE2   1 ? 
ATOM   5823 C CZ    . PHE B 1 237 ? -56.483 17.736  32.218 1.00 23.17  ? 216  PHE B CZ    1 ? 
ATOM   5824 N N     . VAL B 1 238 ? -54.599 13.412  30.073 1.00 20.37  ? 217  VAL B N     1 ? 
ATOM   5825 C CA    . VAL B 1 238 ? -53.893 12.703  31.120 1.00 19.28  ? 217  VAL B CA    1 ? 
ATOM   5826 C C     . VAL B 1 238 ? -54.076 13.487  32.410 1.00 21.92  ? 217  VAL B C     1 ? 
ATOM   5827 O O     . VAL B 1 238 ? -53.864 14.694  32.457 1.00 21.65  ? 217  VAL B O     1 ? 
ATOM   5828 C CB    . VAL B 1 238 ? -52.420 12.491  30.774 1.00 20.68  ? 217  VAL B CB    1 ? 
ATOM   5829 C CG1   . VAL B 1 238 ? -51.616 11.961  31.964 1.00 21.75  ? 217  VAL B CG1   1 ? 
ATOM   5830 C CG2   . VAL B 1 238 ? -52.275 11.604  29.548 1.00 20.10  ? 217  VAL B CG2   1 ? 
ATOM   5831 N N     . ARG B 1 239 ? -54.442 12.774  33.471 1.00 20.42  ? 218  ARG B N     1 ? 
ATOM   5832 C CA    . ARG B 1 239 ? -54.750 13.385  34.750 1.00 22.29  ? 218  ARG B CA    1 ? 
ATOM   5833 C C     . ARG B 1 239 ? -53.640 13.161  35.775 1.00 22.81  ? 218  ARG B C     1 ? 
ATOM   5834 O O     . ARG B 1 239 ? -53.513 13.946  36.709 1.00 22.51  ? 218  ARG B O     1 ? 
ATOM   5835 C CB    . ARG B 1 239 ? -56.081 12.819  35.254 1.00 21.62  ? 218  ARG B CB    1 ? 
ATOM   5836 C CG    . ARG B 1 239 ? -57.234 13.254  34.371 1.00 22.31  ? 218  ARG B CG    1 ? 
ATOM   5837 C CD    . ARG B 1 239 ? -58.499 12.465  34.419 1.00 24.10  ? 218  ARG B CD    1 ? 
ATOM   5838 N NE    . ARG B 1 239 ? -58.832 11.930  35.727 1.00 24.87  ? 218  ARG B NE    1 ? 
ATOM   5839 C CZ    . ARG B 1 239 ? -60.018 11.963  36.313 1.00 29.21  ? 218  ARG B CZ    1 ? 
ATOM   5840 N NH1   . ARG B 1 239 ? -61.017 12.682  35.814 1.00 26.91  ? 218  ARG B NH1   1 ? 
ATOM   5841 N NH2   . ARG B 1 239 ? -60.168 11.258  37.425 1.00 30.68  ? 218  ARG B NH2   1 ? 
ATOM   5842 N N     . LYS B 1 240 ? -52.874 12.086  35.637 1.00 21.71  ? 219  LYS B N     1 ? 
ATOM   5843 C CA    . LYS B 1 240 ? -51.757 11.851  36.528 1.00 23.87  ? 219  LYS B CA    1 ? 
ATOM   5844 C C     . LYS B 1 240 ? -50.971 10.630  36.079 1.00 23.17  ? 219  LYS B C     1 ? 
ATOM   5845 O O     . LYS B 1 240 ? -51.450 9.829   35.275 1.00 20.06  ? 219  LYS B O     1 ? 
ATOM   5846 C CB    . LYS B 1 240 ? -52.151 11.722  38.003 1.00 31.39  ? 219  LYS B CB    1 ? 
ATOM   5847 C CG    . LYS B 1 240 ? -52.942 10.529  38.412 1.00 32.63  ? 219  LYS B CG    1 ? 
ATOM   5848 C CD    . LYS B 1 240 ? -53.201 10.696  39.906 1.00 38.17  ? 219  LYS B CD    1 ? 
ATOM   5849 C CE    . LYS B 1 240 ? -53.923 9.591   40.547 1.00 41.41  ? 219  LYS B CE    1 ? 
ATOM   5850 N NZ    . LYS B 1 240 ? -54.383 10.081  41.854 1.00 44.59  ? 219  LYS B NZ    1 ? 
ATOM   5851 N N     . VAL B 1 241 ? -49.742 10.549  36.591 1.00 19.64  ? 220  VAL B N     1 ? 
ATOM   5852 C CA    . VAL B 1 241 ? -48.837 9.454   36.327 1.00 20.59  ? 220  VAL B CA    1 ? 
ATOM   5853 C C     . VAL B 1 241 ? -49.048 8.455   37.446 1.00 23.68  ? 220  VAL B C     1 ? 
ATOM   5854 O O     . VAL B 1 241 ? -49.338 8.862   38.579 1.00 21.18  ? 220  VAL B O     1 ? 
ATOM   5855 C CB    . VAL B 1 241 ? -47.381 9.937   36.276 1.00 22.58  ? 220  VAL B CB    1 ? 
ATOM   5856 C CG1   . VAL B 1 241 ? -46.400 8.808   36.012 1.00 23.75  ? 220  VAL B CG1   1 ? 
ATOM   5857 C CG2   . VAL B 1 241 ? -47.216 11.035  35.247 1.00 21.87  ? 220  VAL B CG2   1 ? 
ATOM   5858 N N     . LEU B 1 242 ? -48.936 7.165   37.095 1.00 21.38  ? 221  LEU B N     1 ? 
ATOM   5859 C CA    . LEU B 1 242 ? -49.216 6.097   38.041 1.00 23.27  ? 221  LEU B CA    1 ? 
ATOM   5860 C C     . LEU B 1 242 ? -47.902 5.452   38.425 1.00 22.51  ? 221  LEU B C     1 ? 
ATOM   5861 O O     . LEU B 1 242 ? -47.069 5.275   37.540 1.00 23.80  ? 221  LEU B O     1 ? 
ATOM   5862 C CB    . LEU B 1 242 ? -50.154 5.047   37.447 1.00 23.95  ? 221  LEU B CB    1 ? 
ATOM   5863 C CG    . LEU B 1 242 ? -51.530 5.560   37.037 1.00 24.74  ? 221  LEU B CG    1 ? 
ATOM   5864 C CD1   . LEU B 1 242 ? -52.227 4.430   36.320 1.00 27.66  ? 221  LEU B CD1   1 ? 
ATOM   5865 C CD2   . LEU B 1 242 ? -52.303 6.031   38.269 1.00 24.69  ? 221  LEU B CD2   1 ? 
ATOM   5866 N N     . PHE B 1 243 ? -47.813 5.031   39.706 1.00 24.54  ? 222  PHE B N     1 ? 
ATOM   5867 C CA    . PHE B 1 243 ? -46.583 4.513   40.272 1.00 26.75  ? 222  PHE B CA    1 ? 
ATOM   5868 C C     . PHE B 1 243 ? -46.774 3.168   40.978 1.00 28.95  ? 222  PHE B C     1 ? 
ATOM   5869 O O     . PHE B 1 243 ? -47.825 2.914   41.527 1.00 28.29  ? 222  PHE B O     1 ? 
ATOM   5870 C CB    . PHE B 1 243 ? -46.032 5.505   41.299 1.00 26.94  ? 222  PHE B CB    1 ? 
ATOM   5871 C CG    . PHE B 1 243 ? -45.546 6.793   40.656 1.00 26.04  ? 222  PHE B CG    1 ? 
ATOM   5872 C CD1   . PHE B 1 243 ? -44.269 6.887   40.127 1.00 23.12  ? 222  PHE B CD1   1 ? 
ATOM   5873 C CD2   . PHE B 1 243 ? -46.388 7.886   40.547 1.00 25.99  ? 222  PHE B CD2   1 ? 
ATOM   5874 C CE1   . PHE B 1 243 ? -43.815 8.062   39.565 1.00 25.37  ? 222  PHE B CE1   1 ? 
ATOM   5875 C CE2   . PHE B 1 243 ? -45.933 9.068   39.970 1.00 25.49  ? 222  PHE B CE2   1 ? 
ATOM   5876 C CZ    . PHE B 1 243 ? -44.662 9.147   39.472 1.00 28.34  ? 222  PHE B CZ    1 ? 
ATOM   5877 N N     . GLU B 1 244 ? -45.701 2.367   40.979 1.00 33.79  ? 223  GLU B N     1 ? 
ATOM   5878 C CA    . GLU B 1 244 ? -45.449 1.357   41.990 1.00 37.55  ? 223  GLU B CA    1 ? 
ATOM   5879 C C     . GLU B 1 244 ? -44.183 1.748   42.751 1.00 29.62  ? 223  GLU B C     1 ? 
ATOM   5880 O O     . GLU B 1 244 ? -43.094 1.682   42.206 1.00 30.99  ? 223  GLU B O     1 ? 
ATOM   5881 C CB    . GLU B 1 244 ? -45.296 -0.008  41.311 1.00 44.33  ? 223  GLU B CB    1 ? 
ATOM   5882 C CG    . GLU B 1 244 ? -46.635 -0.656  40.966 1.00 57.48  ? 223  GLU B CG    1 ? 
ATOM   5883 C CD    . GLU B 1 244 ? -47.509 -0.953  42.175 1.00 62.36  ? 223  GLU B CD    1 ? 
ATOM   5884 O OE1   . GLU B 1 244 ? -46.958 -1.286  43.264 1.00 57.63  ? 223  GLU B OE1   1 ? 
ATOM   5885 O OE2   . GLU B 1 244 ? -48.747 -0.853  42.006 1.00 64.48  ? 223  GLU B OE2   1 ? 
ATOM   5886 N N     . GLY B 1 245 ? -44.317 2.157   44.009 1.00 32.65  ? 224  GLY B N     1 ? 
ATOM   5887 C CA    . GLY B 1 245 ? -43.175 2.736   44.703 1.00 34.41  ? 224  GLY B CA    1 ? 
ATOM   5888 C C     . GLY B 1 245 ? -42.683 3.976   43.955 1.00 29.36  ? 224  GLY B C     1 ? 
ATOM   5889 O O     . GLY B 1 245 ? -43.494 4.837   43.628 1.00 30.23  ? 224  GLY B O     1 ? 
ATOM   5890 N N     . THR B 1 246 ? -41.382 4.029   43.650 1.00 30.55  ? 225  THR B N     1 ? 
ATOM   5891 C CA    . THR B 1 246 ? -40.788 5.172   42.964 1.00 31.86  ? 225  THR B CA    1 ? 
ATOM   5892 C C     . THR B 1 246 ? -40.690 4.878   41.471 1.00 27.68  ? 225  THR B C     1 ? 
ATOM   5893 O O     . THR B 1 246 ? -40.002 5.584   40.741 1.00 24.91  ? 225  THR B O     1 ? 
ATOM   5894 C CB    . THR B 1 246 ? -39.416 5.492   43.557 1.00 36.22  ? 225  THR B CB    1 ? 
ATOM   5895 O OG1   . THR B 1 246 ? -38.608 4.323   43.460 1.00 38.25  ? 225  THR B OG1   1 ? 
ATOM   5896 C CG2   . THR B 1 246 ? -39.487 5.909   45.016 1.00 38.90  ? 225  THR B CG2   1 ? 
ATOM   5897 N N     . LYS B 1 247 ? -41.392 3.829   41.011 1.00 26.21  ? 226  LYS B N     1 ? 
ATOM   5898 C CA    . LYS B 1 247 ? -41.334 3.446   39.606 1.00 29.32  ? 226  LYS B CA    1 ? 
ATOM   5899 C C     . LYS B 1 247 ? -42.610 3.902   38.895 1.00 25.69  ? 226  LYS B C     1 ? 
ATOM   5900 O O     . LYS B 1 247 ? -43.698 3.543   39.310 1.00 25.61  ? 226  LYS B O     1 ? 
ATOM   5901 C CB    . LYS B 1 247 ? -41.203 1.927   39.455 1.00 32.26  ? 226  LYS B CB    1 ? 
ATOM   5902 C CG    . LYS B 1 247 ? -40.798 1.475   38.075 1.00 37.14  ? 226  LYS B CG    1 ? 
ATOM   5903 C CD    . LYS B 1 247 ? -40.759 -0.041  37.958 1.00 44.30  ? 226  LYS B CD    1 ? 
ATOM   5904 C CE    . LYS B 1 247 ? -40.623 -0.456  36.541 1.00 53.62  ? 226  LYS B CE    1 ? 
ATOM   5905 N NZ    . LYS B 1 247 ? -40.642 -1.916  36.446 1.00 58.87  ? 226  LYS B NZ    1 ? 
ATOM   5906 N N     . ALA B 1 248 ? -42.460 4.692   37.831 1.00 28.92  ? 227  ALA B N     1 ? 
ATOM   5907 C CA    . ALA B 1 248 ? -43.595 5.119   37.022 1.00 27.88  ? 227  ALA B CA    1 ? 
ATOM   5908 C C     . ALA B 1 248 ? -43.983 3.969   36.092 1.00 25.38  ? 227  ALA B C     1 ? 
ATOM   5909 O O     . ALA B 1 248 ? -43.129 3.463   35.369 1.00 25.02  ? 227  ALA B O     1 ? 
ATOM   5910 C CB    . ALA B 1 248 ? -43.226 6.363   36.228 1.00 27.62  ? 227  ALA B CB    1 ? 
ATOM   5911 N N     . ILE B 1 249 ? -45.248 3.543   36.163 1.00 25.88  ? 228  ILE B N     1 ? 
ATOM   5912 C CA    . ILE B 1 249 ? -45.708 2.373   35.430 1.00 27.71  ? 228  ILE B CA    1 ? 
ATOM   5913 C C     . ILE B 1 249 ? -46.806 2.678   34.416 1.00 26.66  ? 228  ILE B C     1 ? 
ATOM   5914 O O     . ILE B 1 249 ? -47.039 1.831   33.551 1.00 26.31  ? 228  ILE B O     1 ? 
ATOM   5915 C CB    . ILE B 1 249 ? -46.178 1.277   36.404 1.00 28.97  ? 228  ILE B CB    1 ? 
ATOM   5916 C CG1   . ILE B 1 249 ? -47.301 1.747   37.300 1.00 26.90  ? 228  ILE B CG1   1 ? 
ATOM   5917 C CG2   . ILE B 1 249 ? -44.974 0.742   37.187 1.00 29.66  ? 228  ILE B CG2   1 ? 
ATOM   5918 C CD1   . ILE B 1 249 ? -48.088 0.628   37.966 1.00 29.04  ? 228  ILE B CD1   1 ? 
ATOM   5919 N N     . GLY B 1 250 ? -47.466 3.845   34.507 1.00 24.28  ? 229  GLY B N     1 ? 
ATOM   5920 C CA    . GLY B 1 250 ? -48.597 4.145   33.633 1.00 23.60  ? 229  GLY B CA    1 ? 
ATOM   5921 C C     . GLY B 1 250 ? -49.122 5.572   33.825 1.00 23.54  ? 229  GLY B C     1 ? 
ATOM   5922 O O     . GLY B 1 250 ? -48.481 6.389   34.494 1.00 21.77  ? 229  GLY B O     1 ? 
ATOM   5923 N N     . VAL B 1 251 ? -50.289 5.834   33.224 1.00 22.90  ? 230  VAL B N     1 ? 
ATOM   5924 C CA    . VAL B 1 251 ? -51.013 7.087   33.368 1.00 21.70  ? 230  VAL B CA    1 ? 
ATOM   5925 C C     . VAL B 1 251 ? -52.499 6.816   33.552 1.00 21.98  ? 230  VAL B C     1 ? 
ATOM   5926 O O     . VAL B 1 251 ? -53.043 5.826   33.043 1.00 23.57  ? 230  VAL B O     1 ? 
ATOM   5927 C CB    . VAL B 1 251 ? -50.788 8.035   32.184 1.00 20.94  ? 230  VAL B CB    1 ? 
ATOM   5928 C CG1   . VAL B 1 251 ? -49.339 8.472   32.097 1.00 21.99  ? 230  VAL B CG1   1 ? 
ATOM   5929 C CG2   . VAL B 1 251 ? -51.229 7.423   30.866 1.00 24.11  ? 230  VAL B CG2   1 ? 
ATOM   5930 N N     . GLU B 1 252 ? -53.146 7.734   34.275 1.00 20.02  ? 231  GLU B N     1 ? 
ATOM   5931 C CA    . GLU B 1 252 ? -54.588 7.817   34.351 1.00 22.02  ? 231  GLU B CA    1 ? 
ATOM   5932 C C     . GLU B 1 252 ? -55.005 8.816   33.286 1.00 22.16  ? 231  GLU B C     1 ? 
ATOM   5933 O O     . GLU B 1 252 ? -54.592 9.984   33.307 1.00 24.29  ? 231  GLU B O     1 ? 
ATOM   5934 C CB    . GLU B 1 252 ? -55.021 8.232   35.761 1.00 24.98  ? 231  GLU B CB    1 ? 
ATOM   5935 C CG    . GLU B 1 252 ? -56.525 8.415   35.930 1.00 24.60  ? 231  GLU B CG    1 ? 
ATOM   5936 C CD    . GLU B 1 252 ? -56.883 9.000   37.291 1.00 27.58  ? 231  GLU B CD    1 ? 
ATOM   5937 O OE1   . GLU B 1 252 ? -57.352 10.159  37.321 1.00 26.93  ? 231  GLU B OE1   1 ? 
ATOM   5938 O OE2   . GLU B 1 252 ? -56.630 8.312   38.316 1.00 27.64  ? 231  GLU B OE2   1 ? 
ATOM   5939 N N     . VAL B 1 253 ? -55.831 8.349   32.355 1.00 20.90  ? 232  VAL B N     1 ? 
ATOM   5940 C CA    . VAL B 1 253 ? -56.163 9.170   31.211 1.00 20.90  ? 232  VAL B CA    1 ? 
ATOM   5941 C C     . VAL B 1 253 ? -57.663 9.097   30.965 1.00 24.05  ? 232  VAL B C     1 ? 
ATOM   5942 O O     . VAL B 1 253 ? -58.277 8.027   31.026 1.00 23.52  ? 232  VAL B O     1 ? 
ATOM   5943 C CB    . VAL B 1 253 ? -55.338 8.746   29.978 1.00 23.03  ? 232  VAL B CB    1 ? 
ATOM   5944 C CG1   . VAL B 1 253 ? -55.589 7.298   29.596 1.00 23.97  ? 232  VAL B CG1   1 ? 
ATOM   5945 C CG2   . VAL B 1 253 ? -55.647 9.611   28.775 1.00 21.36  ? 232  VAL B CG2   1 ? 
ATOM   5946 N N     . GLU B 1 254 ? -58.236 10.276  30.733 1.00 21.89  ? 233  GLU B N     1 ? 
ATOM   5947 C CA    . GLU B 1 254 ? -59.641 10.376  30.414 1.00 24.91  ? 233  GLU B CA    1 ? 
ATOM   5948 C C     . GLU B 1 254 ? -59.792 10.483  28.906 1.00 25.94  ? 233  GLU B C     1 ? 
ATOM   5949 O O     . GLU B 1 254 ? -59.302 11.424  28.291 1.00 25.35  ? 233  GLU B O     1 ? 
ATOM   5950 C CB    . GLU B 1 254 ? -60.263 11.627  31.014 1.00 24.45  ? 233  GLU B CB    1 ? 
ATOM   5951 C CG    . GLU B 1 254 ? -61.733 11.769  30.635 1.00 26.04  ? 233  GLU B CG    1 ? 
ATOM   5952 C CD    . GLU B 1 254 ? -62.096 13.151  30.182 1.00 24.51  ? 233  GLU B CD    1 ? 
ATOM   5953 O OE1   . GLU B 1 254 ? -62.883 13.291  29.236 1.00 27.13  ? 233  GLU B OE1   1 ? 
ATOM   5954 O OE2   . GLU B 1 254 ? -61.486 14.070  30.763 1.00 23.43  ? 233  GLU B OE2   1 ? 
ATOM   5955 N N     . ILE B 1 255 ? -60.535 9.535   28.351 1.00 23.27  ? 234  ILE B N     1 ? 
ATOM   5956 C CA    . ILE B 1 255 ? -60.855 9.496   26.939 1.00 23.94  ? 234  ILE B CA    1 ? 
ATOM   5957 C C     . ILE B 1 255 ? -62.369 9.526   26.812 1.00 26.99  ? 234  ILE B C     1 ? 
ATOM   5958 O O     . ILE B 1 255 ? -63.046 8.555   27.189 1.00 23.63  ? 234  ILE B O     1 ? 
ATOM   5959 C CB    . ILE B 1 255 ? -60.255 8.229   26.303 1.00 29.34  ? 234  ILE B CB    1 ? 
ATOM   5960 C CG1   . ILE B 1 255 ? -58.749 8.230   26.377 1.00 27.71  ? 234  ILE B CG1   1 ? 
ATOM   5961 C CG2   . ILE B 1 255 ? -60.752 8.067   24.860 1.00 31.90  ? 234  ILE B CG2   1 ? 
ATOM   5962 C CD1   . ILE B 1 255 ? -58.101 6.859   26.321 1.00 30.98  ? 234  ILE B CD1   1 ? 
ATOM   5963 N N     . ASP B 1 256 ? -62.887 10.674  26.354 1.00 27.75  ? 235  ASP B N     1 ? 
ATOM   5964 C CA    . ASP B 1 256 ? -64.293 10.833  26.019 1.00 27.82  ? 235  ASP B CA    1 ? 
ATOM   5965 C C     . ASP B 1 256 ? -65.176 10.565  27.230 1.00 28.91  ? 235  ASP B C     1 ? 
ATOM   5966 O O     . ASP B 1 256 ? -66.110 9.752   27.179 1.00 26.76  ? 235  ASP B O     1 ? 
ATOM   5967 C CB    . ASP B 1 256 ? -64.613 9.986   24.800 1.00 32.56  ? 235  ASP B CB    1 ? 
ATOM   5968 C CG    . ASP B 1 256 ? -63.973 10.493  23.513 1.00 40.90  ? 235  ASP B CG    1 ? 
ATOM   5969 O OD1   . ASP B 1 256 ? -63.624 11.704  23.480 1.00 44.15  ? 235  ASP B OD1   1 ? 
ATOM   5970 O OD2   . ASP B 1 256 ? -63.803 9.672   22.582 1.00 43.30  ? 235  ASP B OD2   1 ? 
ATOM   5971 N N     . GLY B 1 257 ? -64.827 11.225  28.335 1.00 24.35  ? 236  GLY B N     1 ? 
ATOM   5972 C CA    . GLY B 1 257 ? -65.614 11.183  29.548 1.00 23.80  ? 236  GLY B CA    1 ? 
ATOM   5973 C C     . GLY B 1 257 ? -65.480 9.901   30.360 1.00 22.70  ? 236  GLY B C     1 ? 
ATOM   5974 O O     . GLY B 1 257 ? -66.210 9.735   31.331 1.00 20.96  ? 236  GLY B O     1 ? 
ATOM   5975 N N     . GLN B 1 258 ? -64.539 9.008   30.006 1.00 22.69  ? 237  GLN B N     1 ? 
ATOM   5976 C CA    . GLN B 1 258 ? -64.289 7.846   30.832 1.00 21.81  ? 237  GLN B CA    1 ? 
ATOM   5977 C C     . GLN B 1 258 ? -62.789 7.660   31.074 1.00 20.77  ? 237  GLN B C     1 ? 
ATOM   5978 O O     . GLN B 1 258 ? -61.943 7.894   30.195 1.00 20.61  ? 237  GLN B O     1 ? 
ATOM   5979 C CB    . GLN B 1 258 ? -64.903 6.611   30.176 1.00 23.38  ? 237  GLN B CB    1 ? 
ATOM   5980 C CG    . GLN B 1 258 ? -66.416 6.659   30.065 1.00 20.78  ? 237  GLN B CG    1 ? 
ATOM   5981 C CD    . GLN B 1 258 ? -67.015 5.403   29.446 1.00 20.25  ? 237  GLN B CD    1 ? 
ATOM   5982 O OE1   . GLN B 1 258 ? -67.688 4.592   30.100 1.00 22.55  ? 237  GLN B OE1   1 ? 
ATOM   5983 N NE2   . GLN B 1 258 ? -66.838 5.279   28.151 1.00 16.99  ? 237  GLN B NE2   1 ? 
ATOM   5984 N N     . ILE B 1 259 ? -62.486 7.197   32.276 1.00 20.50  ? 238  ILE B N     1 ? 
ATOM   5985 C CA    . ILE B 1 259 ? -61.112 7.160   32.754 1.00 21.60  ? 238  ILE B CA    1 ? 
ATOM   5986 C C     . ILE B 1 259 ? -60.593 5.743   32.604 1.00 22.30  ? 238  ILE B C     1 ? 
ATOM   5987 O O     . ILE B 1 259 ? -61.269 4.801   32.981 1.00 22.29  ? 238  ILE B O     1 ? 
ATOM   5988 C CB    . ILE B 1 259 ? -61.027 7.644   34.202 1.00 23.04  ? 238  ILE B CB    1 ? 
ATOM   5989 C CG1   . ILE B 1 259 ? -61.661 8.986   34.359 1.00 25.01  ? 238  ILE B CG1   1 ? 
ATOM   5990 C CG2   . ILE B 1 259 ? -59.574 7.634   34.692 1.00 26.20  ? 238  ILE B CG2   1 ? 
ATOM   5991 C CD1   . ILE B 1 259 ? -62.002 9.284   35.790 1.00 29.57  ? 238  ILE B CD1   1 ? 
ATOM   5992 N N     . GLN B 1 260 ? -59.387 5.629   32.053 1.00 23.19  ? 239  GLN B N     1 ? 
ATOM   5993 C CA    . GLN B 1 260 ? -58.667 4.383   31.918 1.00 23.85  ? 239  GLN B CA    1 ? 
ATOM   5994 C C     . GLN B 1 260 ? -57.284 4.561   32.521 1.00 24.53  ? 239  GLN B C     1 ? 
ATOM   5995 O O     . GLN B 1 260 ? -56.746 5.683   32.587 1.00 23.98  ? 239  GLN B O     1 ? 
ATOM   5996 C CB    . GLN B 1 260 ? -58.459 4.043   30.450 1.00 24.20  ? 239  GLN B CB    1 ? 
ATOM   5997 C CG    . GLN B 1 260 ? -59.733 3.816   29.664 1.00 25.47  ? 239  GLN B CG    1 ? 
ATOM   5998 C CD    . GLN B 1 260 ? -59.429 3.409   28.239 1.00 27.26  ? 239  GLN B CD    1 ? 
ATOM   5999 O OE1   . GLN B 1 260 ? -58.552 2.576   27.993 1.00 31.75  ? 239  GLN B OE1   1 ? 
ATOM   6000 N NE2   . GLN B 1 260 ? -60.091 4.022   27.277 1.00 26.21  ? 239  GLN B NE2   1 ? 
ATOM   6001 N N     . ASN B 1 261 ? -56.724 3.444   32.988 1.00 24.47  ? 240  ASN B N     1 ? 
ATOM   6002 C CA    . ASN B 1 261 ? -55.317 3.402   33.341 1.00 23.79  ? 240  ASN B CA    1 ? 
ATOM   6003 C C     . ASN B 1 261 ? -54.589 2.694   32.216 1.00 24.94  ? 240  ASN B C     1 ? 
ATOM   6004 O O     . ASN B 1 261 ? -54.996 1.609   31.816 1.00 23.44  ? 240  ASN B O     1 ? 
ATOM   6005 C CB    . ASN B 1 261 ? -55.055 2.707   34.662 1.00 24.33  ? 240  ASN B CB    1 ? 
ATOM   6006 C CG    . ASN B 1 261 ? -55.749 3.405   35.802 1.00 27.53  ? 240  ASN B CG    1 ? 
ATOM   6007 O OD1   . ASN B 1 261 ? -55.783 4.637   35.871 1.00 25.95  ? 240  ASN B OD1   1 ? 
ATOM   6008 N ND2   . ASN B 1 261 ? -56.311 2.627   36.712 1.00 26.96  ? 240  ASN B ND2   1 ? 
ATOM   6009 N N     . MET B 1 262 ? -53.553 3.330   31.684 1.00 23.02  ? 241  MET B N     1 ? 
ATOM   6010 C CA    . MET B 1 262 ? -52.787 2.767   30.592 1.00 26.42  ? 241  MET B CA    1 ? 
ATOM   6011 C C     . MET B 1 262 ? -51.340 2.622   31.048 1.00 27.18  ? 241  MET B C     1 ? 
ATOM   6012 O O     . MET B 1 262 ? -50.828 3.510   31.728 1.00 23.86  ? 241  MET B O     1 ? 
ATOM   6013 C CB    . MET B 1 262 ? -52.938 3.655   29.356 1.00 27.51  ? 241  MET B CB    1 ? 
ATOM   6014 C CG    . MET B 1 262 ? -54.339 3.599   28.793 1.00 31.80  ? 241  MET B CG    1 ? 
ATOM   6015 S SD    . MET B 1 262 ? -54.474 4.577   27.291 1.00 41.48  ? 241  MET B SD    1 ? 
ATOM   6016 C CE    . MET B 1 262 ? -56.166 4.205   26.839 1.00 43.66  ? 241  MET B CE    1 ? 
ATOM   6017 N N     . TYR B 1 263 ? -50.696 1.504   30.669 1.00 27.15  ? 242  TYR B N     1 ? 
ATOM   6018 C CA    . TYR B 1 263 ? -49.429 1.103   31.277 1.00 27.90  ? 242  TYR B CA    1 ? 
ATOM   6019 C C     . TYR B 1 263 ? -48.344 0.965   30.219 1.00 26.86  ? 242  TYR B C     1 ? 
ATOM   6020 O O     . TYR B 1 263 ? -48.602 0.662   29.050 1.00 25.33  ? 242  TYR B O     1 ? 
ATOM   6021 C CB    . TYR B 1 263 ? -49.620 -0.196  32.077 1.00 28.26  ? 242  TYR B CB    1 ? 
ATOM   6022 C CG    . TYR B 1 263 ? -50.557 -0.018  33.254 1.00 27.46  ? 242  TYR B CG    1 ? 
ATOM   6023 C CD1   . TYR B 1 263 ? -50.094 0.483   34.464 1.00 31.65  ? 242  TYR B CD1   1 ? 
ATOM   6024 C CD2   . TYR B 1 263 ? -51.909 -0.319  33.160 1.00 29.73  ? 242  TYR B CD2   1 ? 
ATOM   6025 C CE1   . TYR B 1 263 ? -50.939 0.670   35.549 1.00 30.91  ? 242  TYR B CE1   1 ? 
ATOM   6026 C CE2   . TYR B 1 263 ? -52.767 -0.129  34.231 1.00 28.73  ? 242  TYR B CE2   1 ? 
ATOM   6027 C CZ    . TYR B 1 263 ? -52.281 0.366   35.425 1.00 33.07  ? 242  TYR B CZ    1 ? 
ATOM   6028 O OH    . TYR B 1 263 ? -53.121 0.576   36.479 1.00 30.09  ? 242  TYR B OH    1 ? 
ATOM   6029 N N     . ALA B 1 264 ? -47.113 1.228   30.666 1.00 24.63  ? 243  ALA B N     1 ? 
ATOM   6030 C CA    . ALA B 1 264 ? -45.920 1.102   29.856 1.00 25.04  ? 243  ALA B CA    1 ? 
ATOM   6031 C C     . ALA B 1 264 ? -44.944 0.175   30.566 1.00 29.42  ? 243  ALA B C     1 ? 
ATOM   6032 O O     . ALA B 1 264 ? -44.717 0.311   31.765 1.00 30.50  ? 243  ALA B O     1 ? 
ATOM   6033 C CB    . ALA B 1 264 ? -45.263 2.451   29.641 1.00 26.25  ? 243  ALA B CB    1 ? 
ATOM   6034 N N     . SER B 1 265 ? -44.314 -0.718  29.806 1.00 27.91  ? 244  SER B N     1 ? 
ATOM   6035 C CA    . SER B 1 265 ? -43.391 -1.674  30.403 1.00 30.00  ? 244  SER B CA    1 ? 
ATOM   6036 C C     . SER B 1 265 ? -42.007 -1.047  30.611 1.00 32.06  ? 244  SER B C     1 ? 
ATOM   6037 O O     . SER B 1 265 ? -41.244 -1.517  31.441 1.00 32.77  ? 244  SER B O     1 ? 
ATOM   6038 C CB    . SER B 1 265 ? -43.334 -2.916  29.542 1.00 29.95  ? 244  SER B CB    1 ? 
ATOM   6039 O OG    . SER B 1 265 ? -42.746 -2.572  28.302 1.00 29.65  ? 244  SER B OG    1 ? 
ATOM   6040 N N     . LYS B 1 266 ? -41.672 0.036   29.887 1.00 32.58  ? 245  LYS B N     1 ? 
ATOM   6041 C CA    . LYS B 1 266 ? -40.378 0.684   30.067 1.00 29.31  ? 245  LYS B CA    1 ? 
ATOM   6042 C C     . LYS B 1 266 ? -40.528 2.039   30.754 1.00 27.50  ? 245  LYS B C     1 ? 
ATOM   6043 O O     . LYS B 1 266 ? -40.104 2.180   31.896 1.00 30.30  ? 245  LYS B O     1 ? 
ATOM   6044 C CB    . LYS B 1 266 ? -39.616 0.758   28.743 1.00 33.79  ? 245  LYS B CB    1 ? 
ATOM   6045 C CG    . LYS B 1 266 ? -39.341 -0.624  28.157 1.00 38.67  ? 245  LYS B CG    1 ? 
ATOM   6046 C CD    . LYS B 1 266 ? -38.381 -0.616  26.982 1.00 46.85  ? 245  LYS B CD    1 ? 
ATOM   6047 C CE    . LYS B 1 266 ? -38.096 -2.018  26.522 1.00 51.37  ? 245  LYS B CE    1 ? 
ATOM   6048 N NZ    . LYS B 1 266 ? -37.478 -1.933  25.201 1.00 57.52  ? 245  LYS B NZ    1 ? 
ATOM   6049 N N     . GLU B 1 267 ? -41.142 3.035   30.099 1.00 26.18  ? 246  GLU B N     1 ? 
ATOM   6050 C CA    . GLU B 1 267 ? -41.121 4.370   30.673 1.00 27.10  ? 246  GLU B CA    1 ? 
ATOM   6051 C C     . GLU B 1 267 ? -42.291 5.236   30.235 1.00 24.30  ? 246  GLU B C     1 ? 
ATOM   6052 O O     . GLU B 1 267 ? -42.879 5.001   29.183 1.00 22.49  ? 246  GLU B O     1 ? 
ATOM   6053 C CB    . GLU B 1 267 ? -39.868 5.108   30.208 1.00 30.02  ? 246  GLU B CB    1 ? 
ATOM   6054 C CG    . GLU B 1 267 ? -38.562 4.368   30.482 1.00 36.12  ? 246  GLU B CG    1 ? 
ATOM   6055 C CD    . GLU B 1 267 ? -37.311 5.217   30.346 1.00 42.54  ? 246  GLU B CD    1 ? 
ATOM   6056 O OE1   . GLU B 1 267 ? -36.444 4.883   29.546 1.00 40.38  ? 246  GLU B OE1   1 ? 
ATOM   6057 O OE2   . GLU B 1 267 ? -37.188 6.224   31.067 1.00 56.51  ? 246  GLU B OE2   1 ? 
ATOM   6058 N N     . ILE B 1 268 ? -42.567 6.246   31.075 1.00 23.90  ? 247  ILE B N     1 ? 
ATOM   6059 C CA    . ILE B 1 268 ? -43.480 7.345   30.793 1.00 21.97  ? 247  ILE B CA    1 ? 
ATOM   6060 C C     . ILE B 1 268 ? -42.667 8.596   30.465 1.00 22.96  ? 247  ILE B C     1 ? 
ATOM   6061 O O     . ILE B 1 268 ? -41.728 8.929   31.185 1.00 22.85  ? 247  ILE B O     1 ? 
ATOM   6062 C CB    . ILE B 1 268 ? -44.394 7.589   32.012 1.00 21.57  ? 247  ILE B CB    1 ? 
ATOM   6063 C CG1   . ILE B 1 268 ? -45.098 6.292   32.514 1.00 20.69  ? 247  ILE B CG1   1 ? 
ATOM   6064 C CG2   . ILE B 1 268 ? -45.401 8.696   31.710 1.00 21.03  ? 247  ILE B CG2   1 ? 
ATOM   6065 C CD1   . ILE B 1 268 ? -45.940 5.574   31.478 1.00 19.38  ? 247  ILE B CD1   1 ? 
ATOM   6066 N N     . ILE B 1 269 ? -43.038 9.285   29.375 1.00 24.12  ? 248  ILE B N     1 ? 
ATOM   6067 C CA    . ILE B 1 269 ? -42.358 10.487  28.922 1.00 22.39  ? 248  ILE B CA    1 ? 
ATOM   6068 C C     . ILE B 1 269 ? -43.373 11.636  28.901 1.00 22.48  ? 248  ILE B C     1 ? 
ATOM   6069 O O     . ILE B 1 269 ? -44.395 11.553  28.225 1.00 21.09  ? 248  ILE B O     1 ? 
ATOM   6070 C CB    . ILE B 1 269 ? -41.745 10.249  27.529 1.00 24.88  ? 248  ILE B CB    1 ? 
ATOM   6071 C CG1   . ILE B 1 269 ? -40.861 8.995   27.511 1.00 26.15  ? 248  ILE B CG1   1 ? 
ATOM   6072 C CG2   . ILE B 1 269 ? -40.989 11.490  27.041 1.00 23.80  ? 248  ILE B CG2   1 ? 
ATOM   6073 C CD1   . ILE B 1 269 ? -40.535 8.515   26.115 1.00 31.64  ? 248  ILE B CD1   1 ? 
ATOM   6074 N N     . LEU B 1 270 ? -43.111 12.676  29.678 1.00 21.88  ? 249  LEU B N     1 ? 
ATOM   6075 C CA    . LEU B 1 270 ? -43.967 13.857  29.724 1.00 20.77  ? 249  LEU B CA    1 ? 
ATOM   6076 C C     . LEU B 1 270 ? -43.465 14.889  28.721 1.00 19.81  ? 249  LEU B C     1 ? 
ATOM   6077 O O     . LEU B 1 270 ? -42.310 15.316  28.752 1.00 19.37  ? 249  LEU B O     1 ? 
ATOM   6078 C CB    . LEU B 1 270 ? -43.990 14.437  31.133 1.00 21.61  ? 249  LEU B CB    1 ? 
ATOM   6079 C CG    . LEU B 1 270 ? -44.514 13.483  32.203 1.00 20.75  ? 249  LEU B CG    1 ? 
ATOM   6080 C CD1   . LEU B 1 270 ? -44.610 14.199  33.525 1.00 21.91  ? 249  LEU B CD1   1 ? 
ATOM   6081 C CD2   . LEU B 1 270 ? -45.846 12.880  31.882 1.00 22.86  ? 249  LEU B CD2   1 ? 
ATOM   6082 N N     . SER B 1 271 ? -44.359 15.262  27.819 1.00 20.06  ? 250  SER B N     1 ? 
ATOM   6083 C CA    . SER B 1 271 ? -44.101 16.243  26.785 1.00 18.19  ? 250  SER B CA    1 ? 
ATOM   6084 C C     . SER B 1 271 ? -45.301 17.184  26.733 1.00 16.98  ? 250  SER B C     1 ? 
ATOM   6085 O O     . SER B 1 271 ? -45.676 17.623  25.663 1.00 16.81  ? 250  SER B O     1 ? 
ATOM   6086 C CB    . SER B 1 271 ? -43.804 15.563  25.470 1.00 19.54  ? 250  SER B CB    1 ? 
ATOM   6087 O OG    . SER B 1 271 ? -42.644 14.722  25.539 1.00 21.51  ? 250  SER B OG    1 ? 
ATOM   6088 N N     . ALA B 1 272 ? -45.821 17.569  27.916 1.00 17.47  ? 251  ALA B N     1 ? 
ATOM   6089 C CA    . ALA B 1 272 ? -47.048 18.353  28.016 1.00 16.56  ? 251  ALA B CA    1 ? 
ATOM   6090 C C     . ALA B 1 272 ? -46.812 19.864  28.009 1.00 17.51  ? 251  ALA B C     1 ? 
ATOM   6091 O O     . ALA B 1 272 ? -47.769 20.635  28.109 1.00 19.89  ? 251  ALA B O     1 ? 
ATOM   6092 C CB    . ALA B 1 272 ? -47.786 17.940  29.278 1.00 18.10  ? 251  ALA B CB    1 ? 
ATOM   6093 N N     . GLY B 1 273 ? -45.539 20.270  27.923 1.00 17.86  ? 252  GLY B N     1 ? 
ATOM   6094 C CA    . GLY B 1 273 ? -45.117 21.662  27.829 1.00 17.40  ? 252  GLY B CA    1 ? 
ATOM   6095 C C     . GLY B 1 273 ? -44.878 22.330  29.190 1.00 17.74  ? 252  GLY B C     1 ? 
ATOM   6096 O O     . GLY B 1 273 ? -45.159 21.769  30.251 1.00 17.80  ? 252  GLY B O     1 ? 
ATOM   6097 N N     . THR B 1 274 ? -44.415 23.580  29.147 1.00 17.13  ? 253  THR B N     1 ? 
ATOM   6098 C CA    . THR B 1 274 ? -43.932 24.256  30.353 1.00 17.81  ? 253  THR B CA    1 ? 
ATOM   6099 C C     . THR B 1 274 ? -45.028 24.416  31.411 1.00 17.07  ? 253  THR B C     1 ? 
ATOM   6100 O O     . THR B 1 274 ? -44.743 24.386  32.616 1.00 15.56  ? 253  THR B O     1 ? 
ATOM   6101 C CB    . THR B 1 274 ? -43.334 25.606  29.987 1.00 16.61  ? 253  THR B CB    1 ? 
ATOM   6102 O OG1   . THR B 1 274 ? -42.277 25.282  29.085 1.00 17.90  ? 253  THR B OG1   1 ? 
ATOM   6103 C CG2   . THR B 1 274 ? -42.872 26.368  31.220 1.00 17.45  ? 253  THR B CG2   1 ? 
ATOM   6104 N N     . PHE B 1 275 ? -46.269 24.639  30.989 1.00 15.49  ? 254  PHE B N     1 ? 
ATOM   6105 C CA    . PHE B 1 275 ? -47.354 24.830  31.930 1.00 17.18  ? 254  PHE B CA    1 ? 
ATOM   6106 C C     . PHE B 1 275 ? -47.860 23.498  32.487 1.00 17.12  ? 254  PHE B C     1 ? 
ATOM   6107 O O     . PHE B 1 275 ? -48.057 23.362  33.719 1.00 16.93  ? 254  PHE B O     1 ? 
ATOM   6108 C CB    . PHE B 1 275 ? -48.483 25.658  31.286 1.00 16.20  ? 254  PHE B CB    1 ? 
ATOM   6109 C CG    . PHE B 1 275 ? -48.085 27.015  30.738 1.00 16.11  ? 254  PHE B CG    1 ? 
ATOM   6110 C CD1   . PHE B 1 275 ? -47.209 27.851  31.415 1.00 17.50  ? 254  PHE B CD1   1 ? 
ATOM   6111 C CD2   . PHE B 1 275 ? -48.604 27.464  29.540 1.00 20.27  ? 254  PHE B CD2   1 ? 
ATOM   6112 C CE1   . PHE B 1 275 ? -46.879 29.097  30.914 1.00 17.90  ? 254  PHE B CE1   1 ? 
ATOM   6113 C CE2   . PHE B 1 275 ? -48.267 28.708  29.038 1.00 20.48  ? 254  PHE B CE2   1 ? 
ATOM   6114 C CZ    . PHE B 1 275 ? -47.401 29.521  29.724 1.00 21.03  ? 254  PHE B CZ    1 ? 
ATOM   6115 N N     . ASN B 1 276 ? -48.165 22.539  31.595 1.00 17.51  ? 255  ASN B N     1 ? 
ATOM   6116 C CA    . ASN B 1 276 ? -48.932 21.355  32.017 1.00 16.67  ? 255  ASN B CA    1 ? 
ATOM   6117 C C     . ASN B 1 276 ? -48.044 20.226  32.554 1.00 18.08  ? 255  ASN B C     1 ? 
ATOM   6118 O O     . ASN B 1 276 ? -48.505 19.418  33.376 1.00 16.71  ? 255  ASN B O     1 ? 
ATOM   6119 C CB    . ASN B 1 276 ? -49.885 20.859  30.927 1.00 16.32  ? 255  ASN B CB    1 ? 
ATOM   6120 C CG    . ASN B 1 276 ? -51.061 21.798  30.725 1.00 18.85  ? 255  ASN B CG    1 ? 
ATOM   6121 O OD1   . ASN B 1 276 ? -51.230 22.791  31.449 1.00 20.56  ? 255  ASN B OD1   1 ? 
ATOM   6122 N ND2   . ASN B 1 276 ? -51.961 21.440  29.831 1.00 19.42  ? 255  ASN B ND2   1 ? 
ATOM   6123 N N     . THR B 1 277 ? -46.781 20.152  32.140 1.00 18.27  ? 256  THR B N     1 ? 
ATOM   6124 C CA    . THR B 1 277 ? -45.870 19.122  32.671 1.00 18.52  ? 256  THR B CA    1 ? 
ATOM   6125 C C     . THR B 1 277 ? -45.694 19.251  34.188 1.00 18.16  ? 256  THR B C     1 ? 
ATOM   6126 O O     . THR B 1 277 ? -45.938 18.296  34.935 1.00 16.82  ? 256  THR B O     1 ? 
ATOM   6127 C CB    . THR B 1 277 ? -44.529 19.143  31.943 1.00 17.18  ? 256  THR B CB    1 ? 
ATOM   6128 O OG1   . THR B 1 277 ? -44.734 18.514  30.681 1.00 18.16  ? 256  THR B OG1   1 ? 
ATOM   6129 C CG2   . THR B 1 277 ? -43.454 18.346  32.652 1.00 18.77  ? 256  THR B CG2   1 ? 
ATOM   6130 N N     . PRO B 1 278 ? -45.294 20.423  34.729 1.00 19.95  ? 257  PRO B N     1 ? 
ATOM   6131 C CA    . PRO B 1 278 ? -45.194 20.576  36.178 1.00 21.16  ? 257  PRO B CA    1 ? 
ATOM   6132 C C     . PRO B 1 278 ? -46.518 20.375  36.897 1.00 20.05  ? 257  PRO B C     1 ? 
ATOM   6133 O O     . PRO B 1 278 ? -46.502 19.878  38.015 1.00 24.09  ? 257  PRO B O     1 ? 
ATOM   6134 C CB    . PRO B 1 278 ? -44.634 22.000  36.360 1.00 19.76  ? 257  PRO B CB    1 ? 
ATOM   6135 C CG    . PRO B 1 278 ? -45.018 22.687  35.073 1.00 19.23  ? 257  PRO B CG    1 ? 
ATOM   6136 C CD    . PRO B 1 278 ? -44.880 21.639  34.012 1.00 19.45  ? 257  PRO B CD    1 ? 
ATOM   6137 N N     . LYS B 1 279 ? -47.641 20.800  36.298 1.00 18.18  ? 258  LYS B N     1 ? 
ATOM   6138 C CA    . LYS B 1 279 ? -48.958 20.512  36.866 1.00 19.24  ? 258  LYS B CA    1 ? 
ATOM   6139 C C     . LYS B 1 279 ? -49.164 18.998  37.061 1.00 20.71  ? 258  LYS B C     1 ? 
ATOM   6140 O O     . LYS B 1 279 ? -49.583 18.519  38.127 1.00 20.95  ? 258  LYS B O     1 ? 
ATOM   6141 C CB    . LYS B 1 279 ? -50.101 21.102  36.025 1.00 20.09  ? 258  LYS B CB    1 ? 
ATOM   6142 C CG    . LYS B 1 279 ? -51.480 20.656  36.405 1.00 19.44  ? 258  LYS B CG    1 ? 
ATOM   6143 C CD    . LYS B 1 279 ? -52.640 21.319  35.672 1.00 20.87  ? 258  LYS B CD    1 ? 
ATOM   6144 C CE    . LYS B 1 279 ? -53.911 20.503  35.759 1.00 21.33  ? 258  LYS B CE    1 ? 
ATOM   6145 N NZ    . LYS B 1 279 ? -55.021 21.045  34.952 1.00 19.72  ? 258  LYS B NZ    1 ? 
ATOM   6146 N N     . LEU B 1 280 ? -48.887 18.234  36.014 1.00 21.48  ? 259  LEU B N     1 ? 
ATOM   6147 C CA    . LEU B 1 280 ? -49.075 16.784  36.034 1.00 23.99  ? 259  LEU B CA    1 ? 
ATOM   6148 C C     . LEU B 1 280 ? -48.164 16.119  37.071 1.00 19.11  ? 259  LEU B C     1 ? 
ATOM   6149 O O     . LEU B 1 280 ? -48.575 15.216  37.811 1.00 19.07  ? 259  LEU B O     1 ? 
ATOM   6150 C CB    . LEU B 1 280 ? -48.748 16.339  34.609 1.00 26.80  ? 259  LEU B CB    1 ? 
ATOM   6151 C CG    . LEU B 1 280 ? -49.801 15.554  33.841 1.00 38.20  ? 259  LEU B CG    1 ? 
ATOM   6152 C CD1   . LEU B 1 280 ? -51.276 15.853  34.177 1.00 42.73  ? 259  LEU B CD1   1 ? 
ATOM   6153 C CD2   . LEU B 1 280 ? -49.466 15.835  32.383 1.00 35.97  ? 259  LEU B CD2   1 ? 
ATOM   6154 N N     . LEU B 1 281 ? -46.915 16.565  37.112 1.00 18.79  ? 260  LEU B N     1 ? 
ATOM   6155 C CA    . LEU B 1 281 ? -45.941 16.083  38.084 1.00 21.43  ? 260  LEU B CA    1 ? 
ATOM   6156 C C     . LEU B 1 281 ? -46.460 16.317  39.500 1.00 19.93  ? 260  LEU B C     1 ? 
ATOM   6157 O O     . LEU B 1 281 ? -46.484 15.400  40.318 1.00 21.47  ? 260  LEU B O     1 ? 
ATOM   6158 C CB    . LEU B 1 281 ? -44.584 16.760  37.863 1.00 21.88  ? 260  LEU B CB    1 ? 
ATOM   6159 C CG    . LEU B 1 281 ? -43.768 16.274  36.666 1.00 21.98  ? 260  LEU B CG    1 ? 
ATOM   6160 C CD1   . LEU B 1 281 ? -42.589 17.209  36.503 1.00 22.08  ? 260  LEU B CD1   1 ? 
ATOM   6161 C CD2   . LEU B 1 281 ? -43.282 14.812  36.804 1.00 21.84  ? 260  LEU B CD2   1 ? 
ATOM   6162 N N     . LYS B 1 282 ? -46.927 17.541  39.785 1.00 19.68  ? 261  LYS B N     1 ? 
ATOM   6163 C CA    . LYS B 1 282 ? -47.360 17.875  41.131 1.00 18.40  ? 261  LYS B CA    1 ? 
ATOM   6164 C C     . LYS B 1 282 ? -48.593 17.065  41.513 1.00 20.62  ? 261  LYS B C     1 ? 
ATOM   6165 O O     . LYS B 1 282 ? -48.689 16.584  42.646 1.00 21.36  ? 261  LYS B O     1 ? 
ATOM   6166 C CB    . LYS B 1 282 ? -47.588 19.380  41.293 1.00 19.68  ? 261  LYS B CB    1 ? 
ATOM   6167 C CG    . LYS B 1 282 ? -46.331 20.215  41.244 1.00 18.63  ? 261  LYS B CG    1 ? 
ATOM   6168 C CD    . LYS B 1 282 ? -46.547 21.702  41.468 1.00 20.78  ? 261  LYS B CD    1 ? 
ATOM   6169 C CE    . LYS B 1 282 ? -45.256 22.452  41.400 1.00 19.17  ? 261  LYS B CE    1 ? 
ATOM   6170 N NZ    . LYS B 1 282 ? -45.440 23.869  41.709 1.00 22.15  ? 261  LYS B NZ    1 ? 
ATOM   6171 N N     . LEU B 1 283 ? -49.569 16.972  40.600 1.00 21.60  ? 262  LEU B N     1 ? 
ATOM   6172 C CA    . LEU B 1 283 ? -50.776 16.195  40.843 1.00 23.00  ? 262  LEU B CA    1 ? 
ATOM   6173 C C     . LEU B 1 283 ? -50.453 14.731  41.126 1.00 21.83  ? 262  LEU B C     1 ? 
ATOM   6174 O O     . LEU B 1 283 ? -51.204 14.084  41.862 1.00 22.14  ? 262  LEU B O     1 ? 
ATOM   6175 C CB    . LEU B 1 283 ? -51.737 16.349  39.675 1.00 22.36  ? 262  LEU B CB    1 ? 
ATOM   6176 C CG    . LEU B 1 283 ? -52.445 17.699  39.562 1.00 22.53  ? 262  LEU B CG    1 ? 
ATOM   6177 C CD1   . LEU B 1 283 ? -53.292 17.776  38.307 1.00 24.66  ? 262  LEU B CD1   1 ? 
ATOM   6178 C CD2   . LEU B 1 283 ? -53.294 17.984  40.775 1.00 25.71  ? 262  LEU B CD2   1 ? 
ATOM   6179 N N     . SER B 1 284 ? -49.346 14.251  40.564 1.00 22.01  ? 263  SER B N     1 ? 
ATOM   6180 C CA    . SER B 1 284 ? -48.906 12.863  40.678 1.00 23.41  ? 263  SER B CA    1 ? 
ATOM   6181 C C     . SER B 1 284 ? -48.049 12.603  41.924 1.00 23.73  ? 263  SER B C     1 ? 
ATOM   6182 O O     . SER B 1 284 ? -47.587 11.479  42.132 1.00 25.41  ? 263  SER B O     1 ? 
ATOM   6183 C CB    . SER B 1 284 ? -48.114 12.453  39.463 1.00 23.60  ? 263  SER B CB    1 ? 
ATOM   6184 O OG    . SER B 1 284 ? -48.813 12.664  38.250 1.00 22.72  ? 263  SER B OG    1 ? 
ATOM   6185 N N     . GLY B 1 285 ? -47.730 13.664  42.677 1.00 22.00  ? 264  GLY B N     1 ? 
ATOM   6186 C CA    . GLY B 1 285 ? -46.973 13.575  43.919 1.00 23.39  ? 264  GLY B CA    1 ? 
ATOM   6187 C C     . GLY B 1 285 ? -45.470 13.798  43.750 1.00 24.79  ? 264  GLY B C     1 ? 
ATOM   6188 O O     . GLY B 1 285 ? -44.687 13.387  44.599 1.00 23.60  ? 264  GLY B O     1 ? 
ATOM   6189 N N     . VAL B 1 286 ? -45.070 14.435  42.645 1.00 25.53  ? 265  VAL B N     1 ? 
ATOM   6190 C CA    . VAL B 1 286 ? -43.679 14.683  42.319 1.00 25.25  ? 265  VAL B CA    1 ? 
ATOM   6191 C C     . VAL B 1 286 ? -43.492 16.199  42.255 1.00 26.00  ? 265  VAL B C     1 ? 
ATOM   6192 O O     . VAL B 1 286 ? -43.913 16.877  41.311 1.00 22.41  ? 265  VAL B O     1 ? 
ATOM   6193 C CB    . VAL B 1 286 ? -43.234 13.997  41.020 1.00 25.18  ? 265  VAL B CB    1 ? 
ATOM   6194 C CG1   . VAL B 1 286 ? -41.788 14.320  40.682 1.00 27.15  ? 265  VAL B CG1   1 ? 
ATOM   6195 C CG2   . VAL B 1 286 ? -43.449 12.494  41.069 1.00 27.17  ? 265  VAL B CG2   1 ? 
ATOM   6196 N N     . GLY B 1 287 ? -42.831 16.739  43.280 1.00 25.49  ? 266  GLY B N     1 ? 
ATOM   6197 C CA    . GLY B 1 287 ? -42.846 18.170  43.465 1.00 24.77  ? 266  GLY B CA    1 ? 
ATOM   6198 C C     . GLY B 1 287 ? -42.375 18.575  44.846 1.00 24.37  ? 266  GLY B C     1 ? 
ATOM   6199 O O     . GLY B 1 287 ? -41.879 17.742  45.616 1.00 23.74  ? 266  GLY B O     1 ? 
ATOM   6200 N N     . PRO B 1 288 ? -42.445 19.891  45.140 1.00 27.45  ? 267  PRO B N     1 ? 
ATOM   6201 C CA    . PRO B 1 288 ? -42.016 20.425  46.432 1.00 27.63  ? 267  PRO B CA    1 ? 
ATOM   6202 C C     . PRO B 1 288 ? -42.952 19.899  47.516 1.00 24.20  ? 267  PRO B C     1 ? 
ATOM   6203 O O     . PRO B 1 288 ? -44.173 20.000  47.408 1.00 23.82  ? 267  PRO B O     1 ? 
ATOM   6204 C CB    . PRO B 1 288 ? -42.074 21.968  46.268 1.00 25.82  ? 267  PRO B CB    1 ? 
ATOM   6205 C CG    . PRO B 1 288 ? -42.322 22.212  44.788 1.00 24.31  ? 267  PRO B CG    1 ? 
ATOM   6206 C CD    . PRO B 1 288 ? -42.940 20.949  44.244 1.00 26.62  ? 267  PRO B CD    1 ? 
ATOM   6207 N N     . ARG B 1 289 ? -42.362 19.280  48.548 1.00 26.92  ? 268  ARG B N     1 ? 
ATOM   6208 C CA    . ARG B 1 289 ? -43.125 18.586  49.574 1.00 26.65  ? 268  ARG B CA    1 ? 
ATOM   6209 C C     . ARG B 1 289 ? -44.115 19.539  50.225 1.00 23.51  ? 268  ARG B C     1 ? 
ATOM   6210 O O     . ARG B 1 289 ? -45.247 19.142  50.495 1.00 24.28  ? 268  ARG B O     1 ? 
ATOM   6211 C CB    . ARG B 1 289 ? -42.179 17.942  50.606 1.00 33.48  ? 268  ARG B CB    1 ? 
ATOM   6212 C CG    . ARG B 1 289 ? -42.785 17.598  51.960 1.00 41.04  ? 268  ARG B CG    1 ? 
ATOM   6213 C CD    . ARG B 1 289 ? -41.814 16.892  52.890 1.00 42.47  ? 268  ARG B CD    1 ? 
ATOM   6214 N NE    . ARG B 1 289 ? -41.456 15.569  52.377 1.00 41.87  ? 268  ARG B NE    1 ? 
ATOM   6215 C CZ    . ARG B 1 289 ? -42.158 14.457  52.517 1.00 49.34  ? 268  ARG B CZ    1 ? 
ATOM   6216 N NH1   . ARG B 1 289 ? -43.259 14.415  53.247 1.00 56.35  ? 268  ARG B NH1   1 ? 
ATOM   6217 N NH2   . ARG B 1 289 ? -41.728 13.350  51.951 1.00 58.58  ? 268  ARG B NH2   1 ? 
ATOM   6218 N N     . GLU B 1 290 ? -43.709 20.778  50.540 1.00 25.54  ? 269  GLU B N     1 ? 
ATOM   6219 C CA    . GLU B 1 290 ? -44.619 21.676  51.249 1.00 30.15  ? 269  GLU B CA    1 ? 
ATOM   6220 C C     . GLU B 1 290 ? -45.884 21.960  50.440 1.00 24.08  ? 269  GLU B C     1 ? 
ATOM   6221 O O     . GLU B 1 290 ? -46.974 22.008  50.984 1.00 24.96  ? 269  GLU B O     1 ? 
ATOM   6222 C CB    . GLU B 1 290 ? -44.007 23.030  51.618 1.00 40.77  ? 269  GLU B CB    1 ? 
ATOM   6223 C CG    . GLU B 1 290 ? -43.075 22.937  52.819 1.00 53.84  ? 269  GLU B CG    1 ? 
ATOM   6224 C CD    . GLU B 1 290 ? -42.916 24.257  53.560 1.00 69.35  ? 269  GLU B CD    1 ? 
ATOM   6225 O OE1   . GLU B 1 290 ? -42.454 24.168  54.716 1.00 77.65  ? 269  GLU B OE1   1 ? 
ATOM   6226 O OE2   . GLU B 1 290 ? -43.231 25.349  53.016 1.00 69.29  ? 269  GLU B OE2   1 ? 
ATOM   6227 N N     . GLU B 1 291 ? -45.749 22.229  49.150 1.00 23.15  ? 270  GLU B N     1 ? 
ATOM   6228 C CA    . GLU B 1 291 ? -46.931 22.432  48.312 1.00 23.66  ? 270  GLU B CA    1 ? 
ATOM   6229 C C     . GLU B 1 291 ? -47.809 21.175  48.253 1.00 20.46  ? 270  GLU B C     1 ? 
ATOM   6230 O O     . GLU B 1 291 ? -49.024 21.265  48.384 1.00 19.95  ? 270  GLU B O     1 ? 
ATOM   6231 C CB    . GLU B 1 291 ? -46.523 22.879  46.912 1.00 20.74  ? 270  GLU B CB    1 ? 
ATOM   6232 C CG    . GLU B 1 291 ? -47.736 23.211  46.034 1.00 23.31  ? 270  GLU B CG    1 ? 
ATOM   6233 C CD    . GLU B 1 291 ? -47.355 23.682  44.644 1.00 21.84  ? 270  GLU B CD    1 ? 
ATOM   6234 O OE1   . GLU B 1 291 ? -48.256 24.098  43.886 1.00 22.16  ? 270  GLU B OE1   1 ? 
ATOM   6235 O OE2   . GLU B 1 291 ? -46.159 23.631  44.325 1.00 24.34  ? 270  GLU B OE2   1 ? 
ATOM   6236 N N     . LEU B 1 292 ? -47.208 20.008  48.028 1.00 21.99  ? 271  LEU B N     1 ? 
ATOM   6237 C CA    . LEU B 1 292 ? -47.977 18.766  47.944 1.00 24.47  ? 271  LEU B CA    1 ? 
ATOM   6238 C C     . LEU B 1 292 ? -48.749 18.530  49.243 1.00 25.03  ? 271  LEU B C     1 ? 
ATOM   6239 O O     . LEU B 1 292 ? -49.930 18.198  49.197 1.00 25.45  ? 271  LEU B O     1 ? 
ATOM   6240 C CB    . LEU B 1 292 ? -47.139 17.527  47.647 1.00 26.02  ? 271  LEU B CB    1 ? 
ATOM   6241 C CG    . LEU B 1 292 ? -46.306 17.544  46.368 1.00 32.49  ? 271  LEU B CG    1 ? 
ATOM   6242 C CD1   . LEU B 1 292 ? -45.604 16.199  46.187 1.00 35.09  ? 271  LEU B CD1   1 ? 
ATOM   6243 C CD2   . LEU B 1 292 ? -47.173 17.876  45.216 1.00 32.69  ? 271  LEU B CD2   1 ? 
ATOM   6244 N N     . GLU B 1 293 ? -48.078 18.707  50.390 1.00 25.15  ? 272  GLU B N     1 ? 
ATOM   6245 C CA    . GLU B 1 293 ? -48.697 18.445  51.686 1.00 26.65  ? 272  GLU B CA    1 ? 
ATOM   6246 C C     . GLU B 1 293 ? -49.839 19.419  51.943 1.00 28.83  ? 272  GLU B C     1 ? 
ATOM   6247 O O     . GLU B 1 293 ? -50.889 19.012  52.450 1.00 30.58  ? 272  GLU B O     1 ? 
ATOM   6248 C CB    . GLU B 1 293 ? -47.672 18.516  52.814 1.00 30.44  ? 272  GLU B CB    1 ? 
ATOM   6249 C CG    . GLU B 1 293 ? -46.601 17.442  52.658 1.00 36.90  ? 272  GLU B CG    1 ? 
ATOM   6250 C CD    . GLU B 1 293 ? -45.762 17.183  53.902 1.00 39.02  ? 272  GLU B CD    1 ? 
ATOM   6251 O OE1   . GLU B 1 293 ? -45.362 16.009  54.087 1.00 43.74  ? 272  GLU B OE1   1 ? 
ATOM   6252 O OE2   . GLU B 1 293 ? -45.461 18.163  54.610 1.00 40.55  ? 272  GLU B OE2   1 ? 
ATOM   6253 N N     . LYS B 1 294 ? -49.669 20.677  51.516 1.00 27.88  ? 273  LYS B N     1 ? 
ATOM   6254 C CA    . LYS B 1 294 ? -50.717 21.689  51.645 1.00 29.54  ? 273  LYS B CA    1 ? 
ATOM   6255 C C     . LYS B 1 294 ? -52.006 21.223  50.987 1.00 27.01  ? 273  LYS B C     1 ? 
ATOM   6256 O O     . LYS B 1 294 ? -53.086 21.617  51.407 1.00 23.51  ? 273  LYS B O     1 ? 
ATOM   6257 C CB    . LYS B 1 294 ? -50.224 23.006  51.022 1.00 36.98  ? 273  LYS B CB    1 ? 
ATOM   6258 C CG    . LYS B 1 294 ? -51.254 24.040  50.547 1.00 45.74  ? 273  LYS B CG    1 ? 
ATOM   6259 C CD    . LYS B 1 294 ? -50.590 25.363  50.162 1.00 52.05  ? 273  LYS B CD    1 ? 
ATOM   6260 C CE    . LYS B 1 294 ? -51.272 26.130  49.068 1.00 55.49  ? 273  LYS B CE    1 ? 
ATOM   6261 N NZ    . LYS B 1 294 ? -50.420 27.259  48.669 1.00 58.85  ? 273  LYS B NZ    1 ? 
ATOM   6262 N N     . PHE B 1 295 ? -51.892 20.445  49.896 1.00 28.47  ? 274  PHE B N     1 ? 
ATOM   6263 C CA    . PHE B 1 295 ? -53.047 19.939  49.173 1.00 26.55  ? 274  PHE B CA    1 ? 
ATOM   6264 C C     . PHE B 1 295 ? -53.407 18.511  49.578 1.00 26.90  ? 274  PHE B C     1 ? 
ATOM   6265 O O     . PHE B 1 295 ? -54.332 17.948  49.037 1.00 30.29  ? 274  PHE B O     1 ? 
ATOM   6266 C CB    . PHE B 1 295 ? -52.674 19.999  47.680 1.00 24.08  ? 274  PHE B CB    1 ? 
ATOM   6267 C CG    . PHE B 1 295 ? -52.794 21.404  47.116 1.00 24.75  ? 274  PHE B CG    1 ? 
ATOM   6268 C CD1   . PHE B 1 295 ? -54.038 22.041  47.086 1.00 27.45  ? 274  PHE B CD1   1 ? 
ATOM   6269 C CD2   . PHE B 1 295 ? -51.683 22.088  46.630 1.00 25.55  ? 274  PHE B CD2   1 ? 
ATOM   6270 C CE1   . PHE B 1 295 ? -54.161 23.323  46.564 1.00 27.94  ? 274  PHE B CE1   1 ? 
ATOM   6271 C CE2   . PHE B 1 295 ? -51.815 23.373  46.103 1.00 24.17  ? 274  PHE B CE2   1 ? 
ATOM   6272 C CZ    . PHE B 1 295 ? -53.049 23.991  46.082 1.00 26.13  ? 274  PHE B CZ    1 ? 
ATOM   6273 N N     . GLY B 1 296 ? -52.630 17.879  50.449 1.00 29.33  ? 275  GLY B N     1 ? 
ATOM   6274 C CA    . GLY B 1 296 ? -52.926 16.513  50.868 1.00 29.22  ? 275  GLY B CA    1 ? 
ATOM   6275 C C     . GLY B 1 296 ? -52.460 15.465  49.854 1.00 26.99  ? 275  GLY B C     1 ? 
ATOM   6276 O O     . GLY B 1 296 ? -52.831 14.302  49.962 1.00 26.61  ? 275  GLY B O     1 ? 
ATOM   6277 N N     . ILE B 1 297 ? -51.602 15.869  48.908 1.00 24.41  ? 276  ILE B N     1 ? 
ATOM   6278 C CA    . ILE B 1 297 ? -51.186 15.002  47.816 1.00 23.81  ? 276  ILE B CA    1 ? 
ATOM   6279 C C     . ILE B 1 297 ? -50.113 14.049  48.335 1.00 26.35  ? 276  ILE B C     1 ? 
ATOM   6280 O O     . ILE B 1 297 ? -49.123 14.492  48.922 1.00 25.94  ? 276  ILE B O     1 ? 
ATOM   6281 C CB    . ILE B 1 297 ? -50.658 15.810  46.610 1.00 22.74  ? 276  ILE B CB    1 ? 
ATOM   6282 C CG1   . ILE B 1 297 ? -51.749 16.693  46.000 1.00 20.63  ? 276  ILE B CG1   1 ? 
ATOM   6283 C CG2   . ILE B 1 297 ? -50.074 14.875  45.554 1.00 22.78  ? 276  ILE B CG2   1 ? 
ATOM   6284 C CD1   . ILE B 1 297 ? -51.207 17.816  45.130 1.00 21.51  ? 276  ILE B CD1   1 ? 
ATOM   6285 N N     . PRO B 1 298 ? -50.262 12.725  48.109 1.00 28.07  ? 277  PRO B N     1 ? 
ATOM   6286 C CA    . PRO B 1 298 ? -49.208 11.769  48.444 1.00 28.08  ? 277  PRO B CA    1 ? 
ATOM   6287 C C     . PRO B 1 298 ? -47.887 12.218  47.855 1.00 31.98  ? 277  PRO B C     1 ? 
ATOM   6288 O O     . PRO B 1 298 ? -47.830 12.474  46.653 1.00 32.05  ? 277  PRO B O     1 ? 
ATOM   6289 C CB    . PRO B 1 298 ? -49.684 10.447  47.816 1.00 29.67  ? 277  PRO B CB    1 ? 
ATOM   6290 C CG    . PRO B 1 298 ? -51.179 10.622  47.627 1.00 31.98  ? 277  PRO B CG    1 ? 
ATOM   6291 C CD    . PRO B 1 298 ? -51.474 12.099  47.554 1.00 29.29  ? 277  PRO B CD    1 ? 
ATOM   6292 N N     . VAL B 1 299 ? -46.838 12.286  48.688 1.00 29.36  ? 278  VAL B N     1 ? 
ATOM   6293 C CA    . VAL B 1 299 ? -45.514 12.625  48.203 1.00 30.65  ? 278  VAL B CA    1 ? 
ATOM   6294 C C     . VAL B 1 299 ? -44.792 11.363  47.717 1.00 32.60  ? 278  VAL B C     1 ? 
ATOM   6295 O O     . VAL B 1 299 ? -44.213 10.602  48.513 1.00 32.67  ? 278  VAL B O     1 ? 
ATOM   6296 C CB    . VAL B 1 299 ? -44.739 13.344  49.331 1.00 32.92  ? 278  VAL B CB    1 ? 
ATOM   6297 C CG1   . VAL B 1 299 ? -43.350 13.761  48.913 1.00 29.42  ? 278  VAL B CG1   1 ? 
ATOM   6298 C CG2   . VAL B 1 299 ? -45.511 14.536  49.888 1.00 34.48  ? 278  VAL B CG2   1 ? 
ATOM   6299 N N     . ILE B 1 300 ? -44.769 11.188  46.390 1.00 27.07  ? 279  ILE B N     1 ? 
ATOM   6300 C CA    . ILE B 1 300 ? -44.075 10.109  45.723 1.00 27.14  ? 279  ILE B CA    1 ? 
ATOM   6301 C C     . ILE B 1 300 ? -42.587 10.416  45.700 1.00 27.89  ? 279  ILE B C     1 ? 
ATOM   6302 O O     . ILE B 1 300 ? -41.794 9.516   45.939 1.00 27.09  ? 279  ILE B O     1 ? 
ATOM   6303 C CB    . ILE B 1 300 ? -44.630 9.910   44.297 1.00 31.28  ? 279  ILE B CB    1 ? 
ATOM   6304 C CG1   . ILE B 1 300 ? -46.116 9.593   44.297 1.00 38.24  ? 279  ILE B CG1   1 ? 
ATOM   6305 C CG2   . ILE B 1 300 ? -43.827 8.867   43.516 1.00 32.08  ? 279  ILE B CG2   1 ? 
ATOM   6306 C CD1   . ILE B 1 300 ? -46.467 8.202   44.795 1.00 43.80  ? 279  ILE B CD1   1 ? 
ATOM   6307 N N     . ALA B 1 301 ? -42.223 11.669  45.362 1.00 26.02  ? 280  ALA B N     1 ? 
ATOM   6308 C CA    . ALA B 1 301 ? -40.857 12.161  45.463 1.00 26.58  ? 280  ALA B CA    1 ? 
ATOM   6309 C C     . ALA B 1 301 ? -40.839 13.674  45.742 1.00 29.04  ? 280  ALA B C     1 ? 
ATOM   6310 O O     . ALA B 1 301 ? -41.468 14.463  45.036 1.00 27.62  ? 280  ALA B O     1 ? 
ATOM   6311 C CB    . ALA B 1 301 ? -40.092 11.891  44.182 1.00 29.65  ? 280  ALA B CB    1 ? 
ATOM   6312 N N     . ASN B 1 302 ? -40.042 14.068  46.732 1.00 27.73  ? 281  ASN B N     1 ? 
ATOM   6313 C CA    . ASN B 1 302 ? -39.777 15.460  47.028 1.00 29.27  ? 281  ASN B CA    1 ? 
ATOM   6314 C C     . ASN B 1 302 ? -38.808 16.017  45.996 1.00 32.01  ? 281  ASN B C     1 ? 
ATOM   6315 O O     . ASN B 1 302 ? -37.627 15.683  46.029 1.00 31.41  ? 281  ASN B O     1 ? 
ATOM   6316 C CB    . ASN B 1 302 ? -39.218 15.589  48.443 1.00 33.03  ? 281  ASN B CB    1 ? 
ATOM   6317 C CG    . ASN B 1 302 ? -38.925 17.022  48.828 1.00 38.49  ? 281  ASN B CG    1 ? 
ATOM   6318 O OD1   . ASN B 1 302 ? -39.618 17.955  48.399 1.00 32.59  ? 281  ASN B OD1   1 ? 
ATOM   6319 N ND2   . ASN B 1 302 ? -37.901 17.219  49.650 1.00 37.36  ? 281  ASN B ND2   1 ? 
ATOM   6320 N N     . VAL B 1 303 ? -39.316 16.844  45.064 1.00 28.36  ? 282  VAL B N     1 ? 
ATOM   6321 C CA    . VAL B 1 303 ? -38.476 17.459  44.045 1.00 24.51  ? 282  VAL B CA    1 ? 
ATOM   6322 C C     . VAL B 1 303 ? -38.751 18.966  44.064 1.00 27.21  ? 282  VAL B C     1 ? 
ATOM   6323 O O     . VAL B 1 303 ? -39.679 19.454  43.406 1.00 22.86  ? 282  VAL B O     1 ? 
ATOM   6324 C CB    . VAL B 1 303 ? -38.737 16.828  42.660 1.00 24.14  ? 282  VAL B CB    1 ? 
ATOM   6325 C CG1   . VAL B 1 303 ? -37.800 17.379  41.587 1.00 23.93  ? 282  VAL B CG1   1 ? 
ATOM   6326 C CG2   . VAL B 1 303 ? -38.645 15.302  42.690 1.00 23.55  ? 282  VAL B CG2   1 ? 
ATOM   6327 N N     . PRO B 1 304 ? -37.975 19.750  44.853 1.00 26.65  ? 283  PRO B N     1 ? 
ATOM   6328 C CA    . PRO B 1 304 ? -38.213 21.188  45.003 1.00 27.25  ? 283  PRO B CA    1 ? 
ATOM   6329 C C     . PRO B 1 304 ? -38.291 21.996  43.708 1.00 22.91  ? 283  PRO B C     1 ? 
ATOM   6330 O O     . PRO B 1 304 ? -38.925 23.045  43.675 1.00 24.16  ? 283  PRO B O     1 ? 
ATOM   6331 C CB    . PRO B 1 304 ? -37.044 21.684  45.865 1.00 28.29  ? 283  PRO B CB    1 ? 
ATOM   6332 C CG    . PRO B 1 304 ? -36.405 20.453  46.455 1.00 28.74  ? 283  PRO B CG    1 ? 
ATOM   6333 C CD    . PRO B 1 304 ? -36.846 19.257  45.653 1.00 28.03  ? 283  PRO B CD    1 ? 
ATOM   6334 N N     . GLY B 1 305 ? -37.598 21.527  42.667 1.00 21.20  ? 284  GLY B N     1 ? 
ATOM   6335 C CA    . GLY B 1 305 ? -37.451 22.273  41.423 1.00 23.28  ? 284  GLY B CA    1 ? 
ATOM   6336 C C     . GLY B 1 305 ? -38.713 22.310  40.549 1.00 22.83  ? 284  GLY B C     1 ? 
ATOM   6337 O O     . GLY B 1 305 ? -38.809 23.159  39.662 1.00 22.98  ? 284  GLY B O     1 ? 
ATOM   6338 N N     . VAL B 1 306 ? -39.673 21.397  40.792 1.00 23.75  ? 285  VAL B N     1 ? 
ATOM   6339 C CA    . VAL B 1 306 ? -40.835 21.246  39.922 1.00 20.29  ? 285  VAL B CA    1 ? 
ATOM   6340 C C     . VAL B 1 306 ? -41.691 22.508  40.052 1.00 19.69  ? 285  VAL B C     1 ? 
ATOM   6341 O O     . VAL B 1 306 ? -42.091 22.908  41.152 1.00 21.32  ? 285  VAL B O     1 ? 
ATOM   6342 C CB    . VAL B 1 306 ? -41.658 19.980  40.235 1.00 20.87  ? 285  VAL B CB    1 ? 
ATOM   6343 C CG1   . VAL B 1 306 ? -42.913 19.901  39.360 1.00 19.90  ? 285  VAL B CG1   1 ? 
ATOM   6344 C CG2   . VAL B 1 306 ? -40.830 18.689  40.100 1.00 19.15  ? 285  VAL B CG2   1 ? 
ATOM   6345 N N     . GLY B 1 307 ? -41.925 23.187  38.927 1.00 19.44  ? 286  GLY B N     1 ? 
ATOM   6346 C CA    . GLY B 1 307 ? -42.732 24.398  38.949 1.00 19.51  ? 286  GLY B CA    1 ? 
ATOM   6347 C C     . GLY B 1 307 ? -41.936 25.677  39.249 1.00 20.82  ? 286  GLY B C     1 ? 
ATOM   6348 O O     . GLY B 1 307 ? -42.456 26.781  39.050 1.00 19.94  ? 286  GLY B O     1 ? 
ATOM   6349 N N     . GLU B 1 308 ? -40.658 25.525  39.639 1.00 22.02  ? 287  GLU B N     1 ? 
ATOM   6350 C CA    . GLU B 1 308 ? -39.779 26.655  39.921 1.00 22.58  ? 287  GLU B CA    1 ? 
ATOM   6351 C C     . GLU B 1 308 ? -39.062 27.036  38.634 1.00 21.36  ? 287  GLU B C     1 ? 
ATOM   6352 O O     . GLU B 1 308 ? -39.164 26.325  37.637 1.00 20.01  ? 287  GLU B O     1 ? 
ATOM   6353 C CB    . GLU B 1 308 ? -38.784 26.272  41.016 1.00 23.11  ? 287  GLU B CB    1 ? 
ATOM   6354 C CG    . GLU B 1 308 ? -39.466 26.053  42.365 1.00 21.80  ? 287  GLU B CG    1 ? 
ATOM   6355 C CD    . GLU B 1 308 ? -40.143 27.304  42.887 1.00 24.24  ? 287  GLU B CD    1 ? 
ATOM   6356 O OE1   . GLU B 1 308 ? -41.318 27.205  43.239 1.00 26.83  ? 287  GLU B OE1   1 ? 
ATOM   6357 O OE2   . GLU B 1 308 ? -39.514 28.385  42.910 1.00 27.27  ? 287  GLU B OE2   1 ? 
ATOM   6358 N N     . ASN B 1 309 ? -38.360 28.180  38.656 1.00 20.28  ? 288  ASN B N     1 ? 
ATOM   6359 C CA    . ASN B 1 309 ? -37.518 28.570  37.548 1.00 19.21  ? 288  ASN B CA    1 ? 
ATOM   6360 C C     . ASN B 1 309 ? -38.321 28.874  36.276 1.00 19.12  ? 288  ASN B C     1 ? 
ATOM   6361 O O     . ASN B 1 309 ? -37.737 28.871  35.199 1.00 23.16  ? 288  ASN B O     1 ? 
ATOM   6362 C CB    . ASN B 1 309 ? -36.440 27.511  37.277 1.00 19.78  ? 288  ASN B CB    1 ? 
ATOM   6363 C CG    . ASN B 1 309 ? -35.475 27.917  36.191 1.00 23.34  ? 288  ASN B CG    1 ? 
ATOM   6364 O OD1   . ASN B 1 309 ? -34.838 28.973  36.287 1.00 23.34  ? 288  ASN B OD1   1 ? 
ATOM   6365 N ND2   . ASN B 1 309 ? -35.404 27.143  35.113 1.00 23.51  ? 288  ASN B ND2   1 ? 
ATOM   6366 N N     . LEU B 1 310 ? -39.609 29.213  36.383 1.00 21.51  ? 289  LEU B N     1 ? 
ATOM   6367 C CA    . LEU B 1 310 ? -40.371 29.641  35.212 1.00 21.54  ? 289  LEU B CA    1 ? 
ATOM   6368 C C     . LEU B 1 310 ? -39.741 30.929  34.687 1.00 21.81  ? 289  LEU B C     1 ? 
ATOM   6369 O O     . LEU B 1 310 ? -39.615 31.908  35.436 1.00 19.42  ? 289  LEU B O     1 ? 
ATOM   6370 C CB    . LEU B 1 310 ? -41.848 29.883  35.525 1.00 21.93  ? 289  LEU B CB    1 ? 
ATOM   6371 C CG    . LEU B 1 310 ? -42.701 30.460  34.388 1.00 20.19  ? 289  LEU B CG    1 ? 
ATOM   6372 C CD1   . LEU B 1 310 ? -42.773 29.506  33.203 1.00 18.76  ? 289  LEU B CD1   1 ? 
ATOM   6373 C CD2   . LEU B 1 310 ? -44.084 30.801  34.895 1.00 21.74  ? 289  LEU B CD2   1 ? 
ATOM   6374 N N     . ASN B 1 311 ? -39.418 30.940  33.389 1.00 20.86  ? 290  ASN B N     1 ? 
ATOM   6375 C CA    . ASN B 1 311 ? -39.017 32.182  32.750 1.00 24.61  ? 290  ASN B CA    1 ? 
ATOM   6376 C C     . ASN B 1 311 ? -39.517 32.236  31.299 1.00 24.17  ? 290  ASN B C     1 ? 
ATOM   6377 O O     . ASN B 1 311 ? -39.915 31.244  30.694 1.00 21.27  ? 290  ASN B O     1 ? 
ATOM   6378 C CB    . ASN B 1 311 ? -37.523 32.454  32.912 1.00 24.38  ? 290  ASN B CB    1 ? 
ATOM   6379 C CG    . ASN B 1 311 ? -36.626 31.358  32.388 1.00 23.99  ? 290  ASN B CG    1 ? 
ATOM   6380 O OD1   . ASN B 1 311 ? -36.478 30.287  33.003 1.00 30.24  ? 290  ASN B OD1   1 ? 
ATOM   6381 N ND2   . ASN B 1 311 ? -35.916 31.646  31.319 1.00 21.67  ? 290  ASN B ND2   1 ? 
ATOM   6382 N N     . ASP B 1 312 ? -39.508 33.452  30.785 1.00 21.74  ? 291  ASP B N     1 ? 
ATOM   6383 C CA    . ASP B 1 312 ? -40.160 33.782  29.533 1.00 20.59  ? 291  ASP B CA    1 ? 
ATOM   6384 C C     . ASP B 1 312 ? -39.556 35.098  29.050 1.00 22.59  ? 291  ASP B C     1 ? 
ATOM   6385 O O     . ASP B 1 312 ? -38.959 35.834  29.841 1.00 22.11  ? 291  ASP B O     1 ? 
ATOM   6386 C CB    . ASP B 1 312 ? -41.659 33.833  29.755 1.00 19.29  ? 291  ASP B CB    1 ? 
ATOM   6387 C CG    . ASP B 1 312 ? -42.543 34.139  28.551 1.00 18.08  ? 291  ASP B CG    1 ? 
ATOM   6388 O OD1   . ASP B 1 312 ? -42.067 33.933  27.399 1.00 17.66  ? 291  ASP B OD1   1 ? 
ATOM   6389 O OD2   . ASP B 1 312 ? -43.618 34.728  28.794 1.00 18.11  ? 291  ASP B OD2   1 ? 
ATOM   6390 N N     . HIS B 1 313 ? -39.759 35.399  27.764 1.00 21.54  ? 292  HIS B N     1 ? 
ATOM   6391 C CA    . HIS B 1 313 ? -39.374 36.683  27.200 1.00 20.92  ? 292  HIS B CA    1 ? 
ATOM   6392 C C     . HIS B 1 313 ? -40.536 37.664  27.249 1.00 20.49  ? 292  HIS B C     1 ? 
ATOM   6393 O O     . HIS B 1 313 ? -41.691 37.261  27.136 1.00 21.59  ? 292  HIS B O     1 ? 
ATOM   6394 C CB    . HIS B 1 313 ? -38.992 36.524  25.727 1.00 19.83  ? 292  HIS B CB    1 ? 
ATOM   6395 C CG    . HIS B 1 313 ? -37.669 35.878  25.473 1.00 20.83  ? 292  HIS B CG    1 ? 
ATOM   6396 N ND1   . HIS B 1 313 ? -37.508 34.875  24.540 1.00 20.74  ? 292  HIS B ND1   1 ? 
ATOM   6397 C CD2   . HIS B 1 313 ? -36.445 36.144  25.954 1.00 20.09  ? 292  HIS B CD2   1 ? 
ATOM   6398 C CE1   . HIS B 1 313 ? -36.220 34.524  24.500 1.00 23.78  ? 292  HIS B CE1   1 ? 
ATOM   6399 N NE2   . HIS B 1 313 ? -35.542 35.300  25.330 1.00 22.80  ? 292  HIS B NE2   1 ? 
ATOM   6400 N N     . LEU B 1 314 ? -40.200 38.950  27.379 1.00 17.51  ? 293  LEU B N     1 ? 
ATOM   6401 C CA    . LEU B 1 314 ? -41.097 40.062  27.134 1.00 20.31  ? 293  LEU B CA    1 ? 
ATOM   6402 C C     . LEU B 1 314 ? -40.627 40.855  25.917 1.00 21.63  ? 293  LEU B C     1 ? 
ATOM   6403 O O     . LEU B 1 314 ? -39.423 40.993  25.694 1.00 22.80  ? 293  LEU B O     1 ? 
ATOM   6404 C CB    . LEU B 1 314 ? -41.169 40.987  28.344 1.00 21.22  ? 293  LEU B CB    1 ? 
ATOM   6405 C CG    . LEU B 1 314 ? -41.967 40.490  29.553 1.00 22.52  ? 293  LEU B CG    1 ? 
ATOM   6406 C CD1   . LEU B 1 314 ? -41.909 41.534  30.647 1.00 22.90  ? 293  LEU B CD1   1 ? 
ATOM   6407 C CD2   . LEU B 1 314 ? -43.421 40.194  29.212 1.00 22.88  ? 293  LEU B CD2   1 ? 
ATOM   6408 N N     . MET B 1 315 ? -41.619 41.388  25.178 1.00 21.91  ? 294  MET B N     1 ? 
ATOM   6409 C CA    . MET B 1 315 ? -41.412 42.233  24.024 1.00 21.99  ? 294  MET B CA    1 ? 
ATOM   6410 C C     . MET B 1 315 ? -42.075 43.583  24.260 1.00 23.91  ? 294  MET B C     1 ? 
ATOM   6411 O O     . MET B 1 315 ? -43.074 43.678  24.967 1.00 22.75  ? 294  MET B O     1 ? 
ATOM   6412 C CB    . MET B 1 315 ? -42.000 41.613  22.747 1.00 25.21  ? 294  MET B CB    1 ? 
ATOM   6413 C CG    . MET B 1 315 ? -43.469 41.267  22.774 1.00 23.13  ? 294  MET B CG    1 ? 
ATOM   6414 S SD    . MET B 1 315 ? -43.963 40.499  21.210 1.00 25.57  ? 294  MET B SD    1 ? 
ATOM   6415 C CE    . MET B 1 315 ? -45.684 40.150  21.600 1.00 25.12  ? 294  MET B CE    1 ? 
ATOM   6416 N N     . PHE B 1 316 ? -41.486 44.629  23.674 1.00 23.31  ? 295  PHE B N     1 ? 
ATOM   6417 C CA    . PHE B 1 316 ? -42.012 45.971  23.730 1.00 22.18  ? 295  PHE B CA    1 ? 
ATOM   6418 C C     . PHE B 1 316 ? -41.827 46.568  22.341 1.00 21.72  ? 295  PHE B C     1 ? 
ATOM   6419 O O     . PHE B 1 316 ? -40.714 46.577  21.832 1.00 24.15  ? 295  PHE B O     1 ? 
ATOM   6420 C CB    . PHE B 1 316 ? -41.272 46.818  24.775 1.00 22.21  ? 295  PHE B CB    1 ? 
ATOM   6421 C CG    . PHE B 1 316 ? -41.739 48.271  24.788 1.00 24.00  ? 295  PHE B CG    1 ? 
ATOM   6422 C CD1   . PHE B 1 316 ? -43.015 48.606  25.210 1.00 20.63  ? 295  PHE B CD1   1 ? 
ATOM   6423 C CD2   . PHE B 1 316 ? -40.892 49.303  24.373 1.00 24.48  ? 295  PHE B CD2   1 ? 
ATOM   6424 C CE1   . PHE B 1 316 ? -43.432 49.933  25.246 1.00 24.26  ? 295  PHE B CE1   1 ? 
ATOM   6425 C CE2   . PHE B 1 316 ? -41.306 50.628  24.418 1.00 22.76  ? 295  PHE B CE2   1 ? 
ATOM   6426 C CZ    . PHE B 1 316 ? -42.580 50.949  24.830 1.00 22.79  ? 295  PHE B CZ    1 ? 
ATOM   6427 N N     . THR B 1 317 ? -42.925 47.026  21.746 1.00 22.67  ? 296  THR B N     1 ? 
ATOM   6428 C CA    . THR B 1 317 ? -42.929 47.490  20.374 1.00 24.12  ? 296  THR B CA    1 ? 
ATOM   6429 C C     . THR B 1 317 ? -42.775 49.008  20.324 1.00 24.18  ? 296  THR B C     1 ? 
ATOM   6430 O O     . THR B 1 317 ? -43.617 49.731  20.856 1.00 25.80  ? 296  THR B O     1 ? 
ATOM   6431 C CB    . THR B 1 317 ? -44.231 47.069  19.701 1.00 23.76  ? 296  THR B CB    1 ? 
ATOM   6432 O OG1   . THR B 1 317 ? -44.184 45.649  19.627 1.00 23.27  ? 296  THR B OG1   1 ? 
ATOM   6433 C CG2   . THR B 1 317 ? -44.265 47.569  18.269 1.00 23.50  ? 296  THR B CG2   1 ? 
ATOM   6434 N N     . LEU B 1 318 ? -41.748 49.456  19.593 1.00 27.59  ? 297  LEU B N     1 ? 
ATOM   6435 C CA    . LEU B 1 318 ? -41.588 50.843  19.189 1.00 27.97  ? 297  LEU B CA    1 ? 
ATOM   6436 C C     . LEU B 1 318 ? -42.294 51.056  17.852 1.00 26.62  ? 297  LEU B C     1 ? 
ATOM   6437 O O     . LEU B 1 318 ? -42.048 50.313  16.912 1.00 26.25  ? 297  LEU B O     1 ? 
ATOM   6438 C CB    . LEU B 1 318 ? -40.106 51.186  19.067 1.00 30.43  ? 297  LEU B CB    1 ? 
ATOM   6439 C CG    . LEU B 1 318 ? -39.326 51.237  20.379 1.00 36.19  ? 297  LEU B CG    1 ? 
ATOM   6440 C CD1   . LEU B 1 318 ? -39.343 49.937  21.122 1.00 40.49  ? 297  LEU B CD1   1 ? 
ATOM   6441 C CD2   . LEU B 1 318 ? -37.896 51.645  20.058 1.00 39.53  ? 297  LEU B CD2   1 ? 
ATOM   6442 N N     . LYS B 1 319 ? -43.160 52.078  17.784 1.00 23.45  ? 298  LYS B N     1 ? 
ATOM   6443 C CA    . LYS B 1 319 ? -44.026 52.293  16.639 1.00 26.75  ? 298  LYS B CA    1 ? 
ATOM   6444 C C     . LYS B 1 319 ? -43.695 53.636  15.992 1.00 29.34  ? 298  LYS B C     1 ? 
ATOM   6445 O O     . LYS B 1 319 ? -43.429 54.605  16.694 1.00 27.86  ? 298  LYS B O     1 ? 
ATOM   6446 C CB    . LYS B 1 319 ? -45.472 52.251  17.110 1.00 31.11  ? 298  LYS B CB    1 ? 
ATOM   6447 C CG    . LYS B 1 319 ? -45.870 50.867  17.644 1.00 33.82  ? 298  LYS B CG    1 ? 
ATOM   6448 C CD    . LYS B 1 319 ? -47.292 50.834  18.168 1.00 35.09  ? 298  LYS B CD    1 ? 
ATOM   6449 C CE    . LYS B 1 319 ? -47.612 49.546  18.863 1.00 38.78  ? 298  LYS B CE    1 ? 
ATOM   6450 N NZ    . LYS B 1 319 ? -48.975 49.639  19.371 1.00 39.49  ? 298  LYS B NZ    1 ? 
ATOM   6451 N N     . PHE B 1 320 ? -43.678 53.663  14.652 1.00 30.02  ? 299  PHE B N     1 ? 
ATOM   6452 C CA    . PHE B 1 320 ? -43.287 54.857  13.904 1.00 29.33  ? 299  PHE B CA    1 ? 
ATOM   6453 C C     . PHE B 1 320 ? -44.266 55.077  12.755 1.00 31.77  ? 299  PHE B C     1 ? 
ATOM   6454 O O     . PHE B 1 320 ? -44.459 54.172  11.946 1.00 29.10  ? 299  PHE B O     1 ? 
ATOM   6455 C CB    . PHE B 1 320 ? -41.862 54.739  13.359 1.00 28.41  ? 299  PHE B CB    1 ? 
ATOM   6456 C CG    . PHE B 1 320 ? -40.851 54.412  14.441 1.00 28.85  ? 299  PHE B CG    1 ? 
ATOM   6457 C CD1   . PHE B 1 320 ? -40.429 55.390  15.323 1.00 31.08  ? 299  PHE B CD1   1 ? 
ATOM   6458 C CD2   . PHE B 1 320 ? -40.379 53.117  14.611 1.00 30.88  ? 299  PHE B CD2   1 ? 
ATOM   6459 C CE1   . PHE B 1 320 ? -39.534 55.090  16.339 1.00 32.43  ? 299  PHE B CE1   1 ? 
ATOM   6460 C CE2   . PHE B 1 320 ? -39.498 52.818  15.636 1.00 32.75  ? 299  PHE B CE2   1 ? 
ATOM   6461 C CZ    . PHE B 1 320 ? -39.068 53.805  16.494 1.00 32.47  ? 299  PHE B CZ    1 ? 
ATOM   6462 N N     . VAL B 1 321 ? -44.904 56.260  12.733 1.00 32.99  ? 300  VAL B N     1 ? 
ATOM   6463 C CA    . VAL B 1 321 ? -45.788 56.634  11.639 1.00 31.25  ? 300  VAL B CA    1 ? 
ATOM   6464 C C     . VAL B 1 321 ? -44.962 57.405  10.613 1.00 34.98  ? 300  VAL B C     1 ? 
ATOM   6465 O O     . VAL B 1 321 ? -44.093 58.199  10.986 1.00 34.79  ? 300  VAL B O     1 ? 
ATOM   6466 C CB    . VAL B 1 321 ? -47.012 57.447  12.089 1.00 34.20  ? 300  VAL B CB    1 ? 
ATOM   6467 C CG1   . VAL B 1 321 ? -47.869 57.900  10.907 1.00 38.11  ? 300  VAL B CG1   1 ? 
ATOM   6468 C CG2   . VAL B 1 321 ? -47.884 56.652  13.064 1.00 34.94  ? 300  VAL B CG2   1 ? 
ATOM   6469 N N     . SER B 1 322 ? -45.246 57.142  9.329  1.00 33.20  ? 301  SER B N     1 ? 
ATOM   6470 C CA    . SER B 1 322 ? -44.510 57.742  8.224  1.00 36.45  ? 301  SER B CA    1 ? 
ATOM   6471 C C     . SER B 1 322 ? -45.386 58.755  7.479  1.00 38.66  ? 301  SER B C     1 ? 
ATOM   6472 O O     . SER B 1 322 ? -46.558 58.501  7.232  1.00 38.15  ? 301  SER B O     1 ? 
ATOM   6473 C CB    . SER B 1 322 ? -44.010 56.680  7.288  1.00 38.80  ? 301  SER B CB    1 ? 
ATOM   6474 O OG    . SER B 1 322 ? -43.312 57.272  6.192  1.00 41.13  ? 301  SER B OG    1 ? 
ATOM   6475 N N     . GLU B 1 323 ? -44.797 59.888  7.088  1.00 45.60  ? 302  GLU B N     1 ? 
ATOM   6476 C CA    . GLU B 1 323 ? -45.379 60.747  6.068  1.00 46.67  ? 302  GLU B CA    1 ? 
ATOM   6477 C C     . GLU B 1 323 ? -45.183 60.149  4.677  1.00 43.67  ? 302  GLU B C     1 ? 
ATOM   6478 O O     . GLU B 1 323 ? -45.987 60.416  3.783  1.00 46.60  ? 302  GLU B O     1 ? 
ATOM   6479 C CB    . GLU B 1 323 ? -44.763 62.143  5.998  1.00 54.38  ? 302  GLU B CB    1 ? 
ATOM   6480 C CG    . GLU B 1 323 ? -44.870 62.897  7.312  1.00 63.27  ? 302  GLU B CG    1 ? 
ATOM   6481 C CD    . GLU B 1 323 ? -44.952 64.408  7.199  1.00 69.14  ? 302  GLU B CD    1 ? 
ATOM   6482 O OE1   . GLU B 1 323 ? -45.973 64.954  7.690  1.00 67.91  ? 302  GLU B OE1   1 ? 
ATOM   6483 O OE2   . GLU B 1 323 ? -44.004 65.013  6.650  1.00 70.39  ? 302  GLU B OE2   1 ? 
ATOM   6484 N N     . LYS B 1 324 ? -44.110 59.380  4.480  1.00 40.29  ? 303  LYS B N     1 ? 
ATOM   6485 C CA    . LYS B 1 324 ? -43.803 58.831  3.166  1.00 40.55  ? 303  LYS B CA    1 ? 
ATOM   6486 C C     . LYS B 1 324 ? -44.523 57.488  2.986  1.00 45.38  ? 303  LYS B C     1 ? 
ATOM   6487 O O     . LYS B 1 324 ? -44.530 56.639  3.890  1.00 41.20  ? 303  LYS B O     1 ? 
ATOM   6488 C CB    . LYS B 1 324 ? -42.276 58.772  3.013  1.00 43.89  ? 303  LYS B CB    1 ? 
ATOM   6489 C CG    . LYS B 1 324 ? -41.772 58.061  1.748  1.00 53.27  ? 303  LYS B CG    1 ? 
ATOM   6490 C CD    . LYS B 1 324 ? -40.260 57.988  1.586  1.00 62.22  ? 303  LYS B CD    1 ? 
ATOM   6491 C CE    . LYS B 1 324 ? -39.649 59.345  1.463  1.00 76.65  ? 303  LYS B CE    1 ? 
ATOM   6492 N NZ    . LYS B 1 324 ? -38.235 59.266  1.084  1.00 81.26  ? 303  LYS B NZ    1 ? 
ATOM   6493 N N     . ASN B 1 325 ? -45.139 57.298  1.809  1.00 41.24  ? 304  ASN B N     1 ? 
ATOM   6494 C CA    . ASN B 1 325 ? -45.825 56.059  1.487  1.00 39.18  ? 304  ASN B CA    1 ? 
ATOM   6495 C C     . ASN B 1 325 ? -44.831 54.901  1.587  1.00 42.17  ? 304  ASN B C     1 ? 
ATOM   6496 O O     . ASN B 1 325 ? -43.670 55.029  1.209  1.00 35.68  ? 304  ASN B O     1 ? 
ATOM   6497 C CB    . ASN B 1 325 ? -46.467 56.105  0.102  1.00 38.13  ? 304  ASN B CB    1 ? 
ATOM   6498 C CG    . ASN B 1 325 ? -47.313 54.880  -0.192 1.00 40.37  ? 304  ASN B CG    1 ? 
ATOM   6499 O OD1   . ASN B 1 325 ? -48.295 54.635  0.516  1.00 33.04  ? 304  ASN B OD1   1 ? 
ATOM   6500 N ND2   . ASN B 1 325 ? -46.994 54.116  -1.237 1.00 39.56  ? 304  ASN B ND2   1 ? 
ATOM   6501 N N     . ILE B 1 326 ? -45.298 53.762  2.119  1.00 36.89  ? 305  ILE B N     1 ? 
ATOM   6502 C CA    . ILE B 1 326 ? -44.552 52.520  2.031  1.00 34.09  ? 305  ILE B CA    1 ? 
ATOM   6503 C C     . ILE B 1 326 ? -45.362 51.601  1.130  1.00 37.52  ? 305  ILE B C     1 ? 
ATOM   6504 O O     . ILE B 1 326 ? -46.497 51.248  1.467  1.00 34.74  ? 305  ILE B O     1 ? 
ATOM   6505 C CB    . ILE B 1 326 ? -44.267 51.925  3.427  1.00 35.94  ? 305  ILE B CB    1 ? 
ATOM   6506 C CG1   . ILE B 1 326 ? -43.362 52.854  4.246  1.00 37.27  ? 305  ILE B CG1   1 ? 
ATOM   6507 C CG2   . ILE B 1 326 ? -43.662 50.521  3.329  1.00 36.67  ? 305  ILE B CG2   1 ? 
ATOM   6508 C CD1   . ILE B 1 326 ? -43.246 52.475  5.714  1.00 39.66  ? 305  ILE B CD1   1 ? 
ATOM   6509 N N     . GLU B 1 327 ? -44.775 51.277  -0.035 1.00 34.94  ? 306  GLU B N     1 ? 
ATOM   6510 C CA    . GLU B 1 327 ? -45.490 50.661  -1.134 1.00 39.73  ? 306  GLU B CA    1 ? 
ATOM   6511 C C     . GLU B 1 327 ? -46.061 49.300  -0.741 1.00 34.00  ? 306  GLU B C     1 ? 
ATOM   6512 O O     . GLU B 1 327 ? -45.319 48.439  -0.290 1.00 36.80  ? 306  GLU B O     1 ? 
ATOM   6513 C CB    . GLU B 1 327 ? -44.493 50.417  -2.270 1.00 46.42  ? 306  GLU B CB    1 ? 
ATOM   6514 C CG    . GLU B 1 327 ? -44.800 51.137  -3.578 1.00 54.47  ? 306  GLU B CG    1 ? 
ATOM   6515 C CD    . GLU B 1 327 ? -43.995 50.485  -4.694 1.00 56.78  ? 306  GLU B CD    1 ? 
ATOM   6516 O OE1   . GLU B 1 327 ? -44.540 50.308  -5.802 1.00 53.96  ? 306  GLU B OE1   1 ? 
ATOM   6517 O OE2   . GLU B 1 327 ? -42.840 50.095  -4.409 1.00 54.06  ? 306  GLU B OE2   1 ? 
ATOM   6518 N N     . ASP B 1 328 ? -47.355 49.103  -0.993 1.00 34.04  ? 307  ASP B N     1 ? 
ATOM   6519 C CA    . ASP B 1 328 ? -48.040 47.833  -0.791 1.00 35.07  ? 307  ASP B CA    1 ? 
ATOM   6520 C C     . ASP B 1 328 ? -47.926 47.332  0.653  1.00 35.58  ? 307  ASP B C     1 ? 
ATOM   6521 O O     . ASP B 1 328 ? -47.878 46.123  0.877  1.00 36.86  ? 307  ASP B O     1 ? 
ATOM   6522 C CB    . ASP B 1 328 ? -47.553 46.789  -1.786 1.00 35.44  ? 307  ASP B CB    1 ? 
ATOM   6523 C CG    . ASP B 1 328 ? -47.817 47.161  -3.233 1.00 39.29  ? 307  ASP B CG    1 ? 
ATOM   6524 O OD1   . ASP B 1 328 ? -48.878 47.778  -3.490 1.00 39.36  ? 307  ASP B OD1   1 ? 
ATOM   6525 O OD2   . ASP B 1 328 ? -46.962 46.852  -4.063 1.00 40.83  ? 307  ASP B OD2   1 ? 
ATOM   6526 N N     . SER B 1 329 ? -47.917 48.255  1.619  1.00 34.10  ? 308  SER B N     1 ? 
ATOM   6527 C CA    . SER B 1 329 ? -47.727 47.889  3.023  1.00 36.50  ? 308  SER B CA    1 ? 
ATOM   6528 C C     . SER B 1 329 ? -49.059 47.731  3.754  1.00 35.69  ? 308  SER B C     1 ? 
ATOM   6529 O O     . SER B 1 329 ? -49.086 47.104  4.803  1.00 37.61  ? 308  SER B O     1 ? 
ATOM   6530 C CB    . SER B 1 329 ? -46.856 48.896  3.725  1.00 31.39  ? 308  SER B CB    1 ? 
ATOM   6531 O OG    . SER B 1 329 ? -47.434 50.187  3.681  1.00 30.32  ? 308  SER B OG    1 ? 
ATOM   6532 N N     . ILE B 1 330 ? -50.136 48.301  3.197  1.00 37.00  ? 309  ILE B N     1 ? 
ATOM   6533 C CA    . ILE B 1 330 ? -51.433 48.401  3.850  1.00 39.32  ? 309  ILE B CA    1 ? 
ATOM   6534 C C     . ILE B 1 330 ? -52.368 47.381  3.212  1.00 39.65  ? 309  ILE B C     1 ? 
ATOM   6535 O O     . ILE B 1 330 ? -52.770 47.549  2.071  1.00 37.97  ? 309  ILE B O     1 ? 
ATOM   6536 C CB    . ILE B 1 330 ? -52.016 49.823  3.714  1.00 43.79  ? 309  ILE B CB    1 ? 
ATOM   6537 C CG1   . ILE B 1 330 ? -51.041 50.920  4.183  1.00 46.55  ? 309  ILE B CG1   1 ? 
ATOM   6538 C CG2   . ILE B 1 330 ? -53.376 49.945  4.410  1.00 44.21  ? 309  ILE B CG2   1 ? 
ATOM   6539 C CD1   . ILE B 1 330 ? -50.628 50.816  5.635  1.00 47.38  ? 309  ILE B CD1   1 ? 
ATOM   6540 N N     . PHE B 1 331 ? -52.734 46.332  3.954  1.00 42.31  ? 310  PHE B N     1 ? 
ATOM   6541 C CA    . PHE B 1 331 ? -53.621 45.303  3.438  1.00 42.85  ? 310  PHE B CA    1 ? 
ATOM   6542 C C     . PHE B 1 331 ? -54.316 44.631  4.622  1.00 42.19  ? 310  PHE B C     1 ? 
ATOM   6543 O O     . PHE B 1 331 ? -53.947 44.842  5.781  1.00 36.07  ? 310  PHE B O     1 ? 
ATOM   6544 C CB    . PHE B 1 331 ? -52.846 44.272  2.612  1.00 47.12  ? 310  PHE B CB    1 ? 
ATOM   6545 C CG    . PHE B 1 331 ? -51.756 43.607  3.439  1.00 52.52  ? 310  PHE B CG    1 ? 
ATOM   6546 C CD1   . PHE B 1 331 ? -52.033 42.494  4.234  1.00 53.49  ? 310  PHE B CD1   1 ? 
ATOM   6547 C CD2   . PHE B 1 331 ? -50.476 44.139  3.471  1.00 55.90  ? 310  PHE B CD2   1 ? 
ATOM   6548 C CE1   . PHE B 1 331 ? -51.058 41.915  5.028  1.00 53.14  ? 310  PHE B CE1   1 ? 
ATOM   6549 C CE2   . PHE B 1 331 ? -49.504 43.554  4.262  1.00 57.40  ? 310  PHE B CE2   1 ? 
ATOM   6550 C CZ    . PHE B 1 331 ? -49.793 42.445  5.039  1.00 57.43  ? 310  PHE B CZ    1 ? 
ATOM   6551 N N     . ASN B 1 332 ? -55.322 43.821  4.308  1.00 38.35  ? 311  ASN B N     1 ? 
ATOM   6552 C CA    . ASN B 1 332 ? -56.127 43.177  5.331  1.00 37.73  ? 311  ASN B CA    1 ? 
ATOM   6553 C C     . ASN B 1 332 ? -56.039 41.672  5.120  1.00 36.99  ? 311  ASN B C     1 ? 
ATOM   6554 O O     . ASN B 1 332 ? -56.722 41.128  4.256  1.00 37.20  ? 311  ASN B O     1 ? 
ATOM   6555 C CB    . ASN B 1 332 ? -57.563 43.680  5.312  1.00 42.72  ? 311  ASN B CB    1 ? 
ATOM   6556 C CG    . ASN B 1 332 ? -58.420 42.997  6.348  1.00 43.05  ? 311  ASN B CG    1 ? 
ATOM   6557 O OD1   . ASN B 1 332 ? -57.912 42.369  7.279  1.00 41.29  ? 311  ASN B OD1   1 ? 
ATOM   6558 N ND2   . ASN B 1 332 ? -59.724 43.151  6.225  1.00 48.27  ? 311  ASN B ND2   1 ? 
ATOM   6559 N N     . PRO B 1 333 ? -55.201 40.951  5.908  1.00 35.24  ? 312  PRO B N     1 ? 
ATOM   6560 C CA    . PRO B 1 333 ? -55.070 39.499  5.759  1.00 33.89  ? 312  PRO B CA    1 ? 
ATOM   6561 C C     . PRO B 1 333 ? -56.275 38.701  6.251  1.00 30.71  ? 312  PRO B C     1 ? 
ATOM   6562 O O     . PRO B 1 333 ? -56.362 37.509  5.976  1.00 35.07  ? 312  PRO B O     1 ? 
ATOM   6563 C CB    . PRO B 1 333 ? -53.780 39.170  6.559  1.00 32.64  ? 312  PRO B CB    1 ? 
ATOM   6564 C CG    . PRO B 1 333 ? -53.671 40.254  7.596  1.00 33.76  ? 312  PRO B CG    1 ? 
ATOM   6565 C CD    . PRO B 1 333 ? -54.361 41.493  6.992  1.00 36.62  ? 312  PRO B CD    1 ? 
ATOM   6566 N N     . LEU B 1 334 ? -57.201 39.370  6.942  1.00 33.32  ? 313  LEU B N     1 ? 
ATOM   6567 C CA    . LEU B 1 334 ? -58.317 38.712  7.621  1.00 39.36  ? 313  LEU B CA    1 ? 
ATOM   6568 C C     . LEU B 1 334 ? -59.643 38.814  6.857  1.00 39.93  ? 313  LEU B C     1 ? 
ATOM   6569 O O     . LEU B 1 334 ? -60.632 38.230  7.282  1.00 43.86  ? 313  LEU B O     1 ? 
ATOM   6570 C CB    . LEU B 1 334 ? -58.457 39.333  9.011  1.00 36.20  ? 313  LEU B CB    1 ? 
ATOM   6571 C CG    . LEU B 1 334 ? -57.176 39.418  9.843  1.00 34.49  ? 313  LEU B CG    1 ? 
ATOM   6572 C CD1   . LEU B 1 334 ? -57.521 39.901  11.257 1.00 34.64  ? 313  LEU B CD1   1 ? 
ATOM   6573 C CD2   . LEU B 1 334 ? -56.449 38.081  9.878  1.00 32.40  ? 313  LEU B CD2   1 ? 
ATOM   6574 N N     . SER B 1 335 ? -59.680 39.539  5.737  1.00 39.38  ? 314  SER B N     1 ? 
ATOM   6575 C CA    . SER B 1 335 ? -60.902 39.696  4.957  1.00 41.72  ? 314  SER B CA    1 ? 
ATOM   6576 C C     . SER B 1 335 ? -61.307 38.374  4.299  1.00 46.73  ? 314  SER B C     1 ? 
ATOM   6577 O O     . SER B 1 335 ? -60.459 37.532  3.972  1.00 45.44  ? 314  SER B O     1 ? 
ATOM   6578 C CB    . SER B 1 335 ? -60.728 40.761  3.901  1.00 39.18  ? 314  SER B CB    1 ? 
ATOM   6579 O OG    . SER B 1 335 ? -59.945 40.264  2.821  1.00 41.37  ? 314  SER B OG    1 ? 
ATOM   6580 N N     . ASP B 1 336 ? -62.616 38.243  4.033  1.00 46.53  ? 315  ASP B N     1 ? 
ATOM   6581 C CA    . ASP B 1 336 ? -63.183 37.034  3.460  1.00 48.53  ? 315  ASP B CA    1 ? 
ATOM   6582 C C     . ASP B 1 336 ? -62.548 36.775  2.098  1.00 45.68  ? 315  ASP B C     1 ? 
ATOM   6583 O O     . ASP B 1 336 ? -62.292 35.628  1.738  1.00 56.11  ? 315  ASP B O     1 ? 
ATOM   6584 C CB    . ASP B 1 336 ? -64.706 37.101  3.435  1.00 58.55  ? 315  ASP B CB    1 ? 
ATOM   6585 C CG    . ASP B 1 336 ? -65.407 37.139  4.791  1.00 63.55  ? 315  ASP B CG    1 ? 
ATOM   6586 O OD1   . ASP B 1 336 ? -64.842 36.627  5.781  1.00 73.54  ? 315  ASP B OD1   1 ? 
ATOM   6587 O OD2   . ASP B 1 336 ? -66.525 37.691  4.857  1.00 67.75  ? 315  ASP B OD2   1 ? 
ATOM   6588 N N     . GLU B 1 337 ? -62.265 37.849  1.350  1.00 50.21  ? 316  GLU B N     1 ? 
ATOM   6589 C CA    . GLU B 1 337 ? -61.672 37.745  0.026  1.00 46.00  ? 316  GLU B CA    1 ? 
ATOM   6590 C C     . GLU B 1 337 ? -60.232 37.245  0.111  1.00 41.51  ? 316  GLU B C     1 ? 
ATOM   6591 O O     . GLU B 1 337 ? -59.802 36.440  -0.708 1.00 47.39  ? 316  GLU B O     1 ? 
ATOM   6592 C CB    . GLU B 1 337 ? -61.642 39.110  -0.665 1.00 43.89  ? 316  GLU B CB    1 ? 
ATOM   6593 C CG    . GLU B 1 337 ? -61.168 39.027  -2.113 1.00 44.74  ? 316  GLU B CG    1 ? 
ATOM   6594 C CD    . GLU B 1 337 ? -60.827 40.371  -2.748 1.00 50.42  ? 316  GLU B CD    1 ? 
ATOM   6595 O OE1   . GLU B 1 337 ? -60.856 41.408  -2.035 1.00 53.02  ? 316  GLU B OE1   1 ? 
ATOM   6596 O OE2   . GLU B 1 337 ? -60.529 40.375  -3.971 1.00 44.90  ? 316  GLU B OE2   1 ? 
ATOM   6597 N N     . ALA B 1 338 ? -59.459 37.796  1.057  1.00 43.40  ? 317  ALA B N     1 ? 
ATOM   6598 C CA    . ALA B 1 338 ? -58.095 37.328  1.274  1.00 39.40  ? 317  ALA B CA    1 ? 
ATOM   6599 C C     . ALA B 1 338 ? -58.093 35.846  1.650  1.00 35.27  ? 317  ALA B C     1 ? 
ATOM   6600 O O     . ALA B 1 338 ? -57.386 35.039  1.047  1.00 37.09  ? 317  ALA B O     1 ? 
ATOM   6601 C CB    . ALA B 1 338 ? -57.428 38.172  2.321  1.00 36.41  ? 317  ALA B CB    1 ? 
ATOM   6602 N N     . ILE B 1 339 ? -58.875 35.487  2.668  1.00 39.18  ? 318  ILE B N     1 ? 
ATOM   6603 C CA    . ILE B 1 339 ? -58.876 34.115  3.168  1.00 39.25  ? 318  ILE B CA    1 ? 
ATOM   6604 C C     . ILE B 1 339 ? -59.325 33.162  2.052  1.00 46.81  ? 318  ILE B C     1 ? 
ATOM   6605 O O     . ILE B 1 339 ? -58.674 32.146  1.801  1.00 46.04  ? 318  ILE B O     1 ? 
ATOM   6606 C CB    . ILE B 1 339 ? -59.707 34.032  4.460  1.00 41.73  ? 318  ILE B CB    1 ? 
ATOM   6607 C CG1   . ILE B 1 339 ? -58.998 34.791  5.576  1.00 42.38  ? 318  ILE B CG1   1 ? 
ATOM   6608 C CG2   . ILE B 1 339 ? -59.985 32.586  4.853  1.00 44.59  ? 318  ILE B CG2   1 ? 
ATOM   6609 C CD1   . ILE B 1 339 ? -59.723 34.843  6.910  1.00 48.99  ? 318  ILE B CD1   1 ? 
ATOM   6610 N N     . ASP B 1 340 ? -60.373 33.533  1.305  1.00 55.23  ? 319  ASP B N     1 ? 
ATOM   6611 C CA    . ASP B 1 340 ? -60.806 32.737  0.157  1.00 58.07  ? 319  ASP B CA    1 ? 
ATOM   6612 C C     . ASP B 1 340 ? -59.673 32.563  -0.847 1.00 48.28  ? 319  ASP B C     1 ? 
ATOM   6613 O O     . ASP B 1 340 ? -59.390 31.452  -1.304 1.00 49.17  ? 319  ASP B O     1 ? 
ATOM   6614 C CB    . ASP B 1 340 ? -62.029 33.323  -0.540 1.00 68.19  ? 319  ASP B CB    1 ? 
ATOM   6615 C CG    . ASP B 1 340 ? -63.363 32.691  -0.176 1.00 70.87  ? 319  ASP B CG    1 ? 
ATOM   6616 O OD1   . ASP B 1 340 ? -63.686 32.672  1.030  1.00 79.99  ? 319  ASP B OD1   1 ? 
ATOM   6617 O OD2   . ASP B 1 340 ? -64.041 32.201  -1.106 1.00 76.34  ? 319  ASP B OD2   1 ? 
ATOM   6618 N N     . GLN B 1 341 ? -59.014 33.671  -1.189 1.00 51.48  ? 320  GLN B N     1 ? 
ATOM   6619 C CA    . GLN B 1 341 ? -57.934 33.609  -2.157 1.00 52.43  ? 320  GLN B CA    1 ? 
ATOM   6620 C C     . GLN B 1 341 ? -56.898 32.598  -1.676 1.00 53.66  ? 320  GLN B C     1 ? 
ATOM   6621 O O     . GLN B 1 341 ? -56.310 31.882  -2.487 1.00 60.73  ? 320  GLN B O     1 ? 
ATOM   6622 C CB    . GLN B 1 341 ? -57.332 34.993  -2.385 1.00 55.30  ? 320  GLN B CB    1 ? 
ATOM   6623 C CG    . GLN B 1 341 ? -56.598 35.140  -3.710 1.00 54.95  ? 320  GLN B CG    1 ? 
ATOM   6624 C CD    . GLN B 1 341 ? -55.910 36.484  -3.839 1.00 60.18  ? 320  GLN B CD    1 ? 
ATOM   6625 O OE1   . GLN B 1 341 ? -56.455 37.536  -3.473 1.00 55.39  ? 320  GLN B OE1   1 ? 
ATOM   6626 N NE2   . GLN B 1 341 ? -54.680 36.457  -4.338 1.00 65.96  ? 320  GLN B NE2   1 ? 
ATOM   6627 N N     . TRP B 1 342 ? -56.687 32.548  -0.349 1.00 50.72  ? 321  TRP B N     1 ? 
ATOM   6628 C CA    . TRP B 1 342 ? -55.699 31.655  0.236  1.00 44.73  ? 321  TRP B CA    1 ? 
ATOM   6629 C C     . TRP B 1 342 ? -56.155 30.203  0.087  1.00 38.97  ? 321  TRP B C     1 ? 
ATOM   6630 O O     . TRP B 1 342 ? -55.384 29.357  -0.356 1.00 39.07  ? 321  TRP B O     1 ? 
ATOM   6631 C CB    . TRP B 1 342 ? -55.399 32.015  1.705  1.00 37.73  ? 321  TRP B CB    1 ? 
ATOM   6632 C CG    . TRP B 1 342 ? -54.308 31.146  2.273  1.00 30.94  ? 321  TRP B CG    1 ? 
ATOM   6633 C CD1   . TRP B 1 342 ? -52.962 31.341  2.208  1.00 29.72  ? 321  TRP B CD1   1 ? 
ATOM   6634 C CD2   . TRP B 1 342 ? -54.497 29.868  2.907  1.00 30.76  ? 321  TRP B CD2   1 ? 
ATOM   6635 N NE1   . TRP B 1 342 ? -52.300 30.284  2.783  1.00 30.65  ? 321  TRP B NE1   1 ? 
ATOM   6636 C CE2   . TRP B 1 342 ? -53.216 29.367  3.217  1.00 28.75  ? 321  TRP B CE2   1 ? 
ATOM   6637 C CE3   . TRP B 1 342 ? -55.628 29.114  3.248  1.00 33.83  ? 321  TRP B CE3   1 ? 
ATOM   6638 C CZ2   . TRP B 1 342 ? -53.033 28.141  3.857  1.00 30.04  ? 321  TRP B CZ2   1 ? 
ATOM   6639 C CZ3   . TRP B 1 342 ? -55.451 27.897  3.870  1.00 31.73  ? 321  TRP B CZ3   1 ? 
ATOM   6640 C CH2   . TRP B 1 342 ? -54.166 27.413  4.153  1.00 32.58  ? 321  TRP B CH2   1 ? 
ATOM   6641 N N     . TYR B 1 343 ? -57.400 29.908  0.471  1.00 46.35  ? 322  TYR B N     1 ? 
ATOM   6642 C CA    . TYR B 1 343 ? -57.913 28.555  0.323  1.00 53.77  ? 322  TYR B CA    1 ? 
ATOM   6643 C C     . TYR B 1 343 ? -57.773 28.120  -1.135 1.00 61.81  ? 322  TYR B C     1 ? 
ATOM   6644 O O     . TYR B 1 343 ? -57.293 27.018  -1.398 1.00 58.50  ? 322  TYR B O     1 ? 
ATOM   6645 C CB    . TYR B 1 343 ? -59.361 28.408  0.787  1.00 52.00  ? 322  TYR B CB    1 ? 
ATOM   6646 C CG    . TYR B 1 343 ? -59.521 28.325  2.299  1.00 56.08  ? 322  TYR B CG    1 ? 
ATOM   6647 C CD1   . TYR B 1 343 ? -59.197 27.166  2.996  1.00 54.29  ? 322  TYR B CD1   1 ? 
ATOM   6648 C CD2   . TYR B 1 343 ? -60.036 29.396  3.023  1.00 53.69  ? 322  TYR B CD2   1 ? 
ATOM   6649 C CE1   . TYR B 1 343 ? -59.357 27.091  4.372  1.00 56.06  ? 322  TYR B CE1   1 ? 
ATOM   6650 C CE2   . TYR B 1 343 ? -60.203 29.325  4.395  1.00 51.54  ? 322  TYR B CE2   1 ? 
ATOM   6651 C CZ    . TYR B 1 343 ? -59.852 28.176  5.073  1.00 49.96  ? 322  TYR B CZ    1 ? 
ATOM   6652 O OH    . TYR B 1 343 ? -60.046 28.146  6.423  1.00 54.71  ? 322  TYR B OH    1 ? 
ATOM   6653 N N     . LYS B 1 344 ? -58.144 29.018  -2.066 1.00 65.04  ? 323  LYS B N     1 ? 
ATOM   6654 C CA    . LYS B 1 344 ? -58.260 28.671  -3.472 1.00 67.98  ? 323  LYS B CA    1 ? 
ATOM   6655 C C     . LYS B 1 344 ? -56.902 28.335  -4.073 1.00 71.69  ? 323  LYS B C     1 ? 
ATOM   6656 O O     . LYS B 1 344 ? -56.738 27.243  -4.608 1.00 82.14  ? 323  LYS B O     1 ? 
ATOM   6657 C CB    . LYS B 1 344 ? -58.959 29.761  -4.282 1.00 71.98  ? 323  LYS B CB    1 ? 
ATOM   6658 C CG    . LYS B 1 344 ? -60.463 29.739  -4.111 1.00 78.32  ? 323  LYS B CG    1 ? 
ATOM   6659 C CD    . LYS B 1 344 ? -61.227 30.427  -5.234 1.00 81.10  ? 323  LYS B CD    1 ? 
ATOM   6660 C CE    . LYS B 1 344 ? -62.694 30.335  -4.982 1.00 78.57  ? 323  LYS B CE    1 ? 
ATOM   6661 N NZ    . LYS B 1 344 ? -63.459 30.962  -6.057 1.00 82.19  ? 323  LYS B NZ    1 ? 
ATOM   6662 N N     . ASN B 1 345 ? -55.934 29.257  -4.002 1.00 78.40  ? 324  ASN B N     1 ? 
ATOM   6663 C CA    . ASN B 1 345 ? -54.651 29.016  -4.650 1.00 75.58  ? 324  ASN B CA    1 ? 
ATOM   6664 C C     . ASN B 1 345 ? -53.464 29.455  -3.791 1.00 67.74  ? 324  ASN B C     1 ? 
ATOM   6665 O O     . ASN B 1 345 ? -52.376 29.634  -4.331 1.00 63.49  ? 324  ASN B O     1 ? 
ATOM   6666 C CB    . ASN B 1 345 ? -54.597 29.679  -6.023 1.00 86.04  ? 324  ASN B CB    1 ? 
ATOM   6667 C CG    . ASN B 1 345 ? -54.698 31.186  -5.953 1.00 93.72  ? 324  ASN B CG    1 ? 
ATOM   6668 O OD1   . ASN B 1 345 ? -55.225 31.745  -4.985 1.00 87.19  ? 324  ASN B OD1   1 ? 
ATOM   6669 N ND2   . ASN B 1 345 ? -54.227 31.864  -6.988 1.00 107.04 ? 324  ASN B ND2   1 ? 
ATOM   6670 N N     . LYS B 1 346 ? -53.659 29.603  -2.470 1.00 62.21  ? 325  LYS B N     1 ? 
ATOM   6671 C CA    . LYS B 1 346 ? -52.560 29.859  -1.545 1.00 52.03  ? 325  LYS B CA    1 ? 
ATOM   6672 C C     . LYS B 1 346 ? -51.787 31.123  -1.915 1.00 46.31  ? 325  LYS B C     1 ? 
ATOM   6673 O O     . LYS B 1 346 ? -50.558 31.135  -1.831 1.00 48.07  ? 325  LYS B O     1 ? 
ATOM   6674 C CB    . LYS B 1 346 ? -51.567 28.689  -1.506 1.00 53.08  ? 325  LYS B CB    1 ? 
ATOM   6675 C CG    . LYS B 1 346 ? -52.164 27.354  -1.120 1.00 54.17  ? 325  LYS B CG    1 ? 
ATOM   6676 C CD    . LYS B 1 346 ? -52.493 27.247  0.365  1.00 57.46  ? 325  LYS B CD    1 ? 
ATOM   6677 C CE    . LYS B 1 346 ? -53.357 26.071  0.670  1.00 56.67  ? 325  LYS B CE    1 ? 
ATOM   6678 N NZ    . LYS B 1 346 ? -54.747 26.375  0.303  1.00 58.72  ? 325  LYS B NZ    1 ? 
ATOM   6679 N N     . THR B 1 347 ? -52.511 32.184  -2.300 1.00 48.34  ? 326  THR B N     1 ? 
ATOM   6680 C CA    . THR B 1 347 ? -51.906 33.487  -2.532 1.00 49.09  ? 326  THR B CA    1 ? 
ATOM   6681 C C     . THR B 1 347 ? -52.783 34.567  -1.910 1.00 42.53  ? 326  THR B C     1 ? 
ATOM   6682 O O     . THR B 1 347 ? -53.900 34.309  -1.475 1.00 42.30  ? 326  THR B O     1 ? 
ATOM   6683 C CB    . THR B 1 347 ? -51.708 33.752  -4.031 1.00 53.71  ? 326  THR B CB    1 ? 
ATOM   6684 O OG1   . THR B 1 347 ? -52.965 33.569  -4.681 1.00 53.58  ? 326  THR B OG1   1 ? 
ATOM   6685 C CG2   . THR B 1 347 ? -50.647 32.858  -4.647 1.00 51.21  ? 326  THR B CG2   1 ? 
ATOM   6686 N N     . GLY B 1 348 ? -52.250 35.789  -1.901 1.00 46.18  ? 327  GLY B N     1 ? 
ATOM   6687 C CA    . GLY B 1 348 ? -53.029 36.957  -1.530 1.00 45.52  ? 327  GLY B CA    1 ? 
ATOM   6688 C C     . GLY B 1 348 ? -52.571 37.520  -0.191 1.00 37.43  ? 327  GLY B C     1 ? 
ATOM   6689 O O     . GLY B 1 348 ? -51.572 37.068  0.363  1.00 37.89  ? 327  GLY B O     1 ? 
ATOM   6690 N N     . PRO B 1 349 ? -53.288 38.529  0.342  1.00 35.05  ? 328  PRO B N     1 ? 
ATOM   6691 C CA    . PRO B 1 349 ? -52.894 39.187  1.589  1.00 35.34  ? 328  PRO B CA    1 ? 
ATOM   6692 C C     . PRO B 1 349 ? -52.738 38.298  2.831  1.00 37.66  ? 328  PRO B C     1 ? 
ATOM   6693 O O     . PRO B 1 349 ? -51.978 38.640  3.743  1.00 34.74  ? 328  PRO B O     1 ? 
ATOM   6694 C CB    . PRO B 1 349 ? -54.019 40.225  1.749  1.00 38.21  ? 328  PRO B CB    1 ? 
ATOM   6695 C CG    . PRO B 1 349 ? -54.485 40.516  0.323  1.00 37.55  ? 328  PRO B CG    1 ? 
ATOM   6696 C CD    . PRO B 1 349 ? -54.478 39.140  -0.280 1.00 36.46  ? 328  PRO B CD    1 ? 
ATOM   6697 N N     . SER B 1 350 ? -53.464 37.170  2.878  1.00 32.67  ? 329  SER B N     1 ? 
ATOM   6698 C CA    . SER B 1 350 ? -53.428 36.267  4.021  1.00 29.77  ? 329  SER B CA    1 ? 
ATOM   6699 C C     . SER B 1 350 ? -52.072 35.560  4.125  1.00 32.72  ? 329  SER B C     1 ? 
ATOM   6700 O O     . SER B 1 350 ? -51.786 34.915  5.140  1.00 28.74  ? 329  SER B O     1 ? 
ATOM   6701 C CB    . SER B 1 350 ? -54.552 35.260  3.922  1.00 31.61  ? 329  SER B CB    1 ? 
ATOM   6702 O OG    . SER B 1 350 ? -55.832 35.867  3.975  1.00 26.61  ? 329  SER B OG    1 ? 
ATOM   6703 N N     . SER B 1 351 ? -51.224 35.703  3.080  1.00 29.92  ? 330  SER B N     1 ? 
ATOM   6704 C CA    . SER B 1 351 ? -49.885 35.124  3.084  1.00 27.65  ? 330  SER B CA    1 ? 
ATOM   6705 C C     . SER B 1 351 ? -48.955 35.914  4.001  1.00 25.06  ? 330  SER B C     1 ? 
ATOM   6706 O O     . SER B 1 351 ? -47.917 35.424  4.388  1.00 27.01  ? 330  SER B O     1 ? 
ATOM   6707 C CB    . SER B 1 351 ? -49.281 35.096  1.675  1.00 34.80  ? 330  SER B CB    1 ? 
ATOM   6708 O OG    . SER B 1 351 ? -50.239 34.711  0.695  1.00 35.06  ? 330  SER B OG    1 ? 
ATOM   6709 N N     . TYR B 1 352 ? -49.316 37.153  4.333  1.00 29.37  ? 331  TYR B N     1 ? 
ATOM   6710 C CA    . TYR B 1 352 ? -48.375 38.098  4.915  1.00 31.37  ? 331  TYR B CA    1 ? 
ATOM   6711 C C     . TYR B 1 352 ? -48.605 38.224  6.421  1.00 28.46  ? 331  TYR B C     1 ? 
ATOM   6712 O O     . TYR B 1 352 ? -49.691 38.610  6.858  1.00 31.33  ? 331  TYR B O     1 ? 
ATOM   6713 C CB    . TYR B 1 352 ? -48.592 39.423  4.180  1.00 33.37  ? 331  TYR B CB    1 ? 
ATOM   6714 C CG    . TYR B 1 352 ? -48.334 39.351  2.673  1.00 36.54  ? 331  TYR B CG    1 ? 
ATOM   6715 C CD1   . TYR B 1 352 ? -47.247 38.650  2.158  1.00 32.86  ? 331  TYR B CD1   1 ? 
ATOM   6716 C CD2   . TYR B 1 352 ? -49.210 39.951  1.759  1.00 37.36  ? 331  TYR B CD2   1 ? 
ATOM   6717 C CE1   . TYR B 1 352 ? -47.014 38.580  0.790  1.00 36.79  ? 331  TYR B CE1   1 ? 
ATOM   6718 C CE2   . TYR B 1 352 ? -49.006 39.862  0.390  1.00 37.83  ? 331  TYR B CE2   1 ? 
ATOM   6719 C CZ    . TYR B 1 352 ? -47.894 39.189  -0.089 1.00 39.52  ? 331  TYR B CZ    1 ? 
ATOM   6720 O OH    . TYR B 1 352 ? -47.661 39.097  -1.421 1.00 44.64  ? 331  TYR B OH    1 ? 
ATOM   6721 N N     . TYR B 1 353 ? -47.573 37.877  7.198  1.00 29.19  ? 332  TYR B N     1 ? 
ATOM   6722 C CA    . TYR B 1 353 ? -47.478 38.265  8.598  1.00 29.20  ? 332  TYR B CA    1 ? 
ATOM   6723 C C     . TYR B 1 353 ? -46.526 39.459  8.670  1.00 26.53  ? 332  TYR B C     1 ? 
ATOM   6724 O O     . TYR B 1 353 ? -45.432 39.362  8.157  1.00 26.62  ? 332  TYR B O     1 ? 
ATOM   6725 C CB    . TYR B 1 353 ? -47.012 37.069  9.440  1.00 29.85  ? 332  TYR B CB    1 ? 
ATOM   6726 C CG    . TYR B 1 353 ? -47.097 37.376  10.928 1.00 29.80  ? 332  TYR B CG    1 ? 
ATOM   6727 C CD1   . TYR B 1 353 ? -48.310 37.295  11.598 1.00 33.98  ? 332  TYR B CD1   1 ? 
ATOM   6728 C CD2   . TYR B 1 353 ? -45.998 37.844  11.637 1.00 31.29  ? 332  TYR B CD2   1 ? 
ATOM   6729 C CE1   . TYR B 1 353 ? -48.426 37.645  12.938 1.00 33.96  ? 332  TYR B CE1   1 ? 
ATOM   6730 C CE2   . TYR B 1 353 ? -46.090 38.169  12.983 1.00 29.93  ? 332  TYR B CE2   1 ? 
ATOM   6731 C CZ    . TYR B 1 353 ? -47.310 38.065  13.630 1.00 32.89  ? 332  TYR B CZ    1 ? 
ATOM   6732 O OH    . TYR B 1 353 ? -47.444 38.403  14.935 1.00 37.94  ? 332  TYR B OH    1 ? 
ATOM   6733 N N     . PRO B 1 354 ? -46.887 40.596  9.310  1.00 31.33  ? 333  PRO B N     1 ? 
ATOM   6734 C CA    . PRO B 1 354 ? -46.052 41.804  9.265  1.00 33.41  ? 333  PRO B CA    1 ? 
ATOM   6735 C C     . PRO B 1 354 ? -44.649 41.696  9.869  1.00 29.83  ? 333  PRO B C     1 ? 
ATOM   6736 O O     . PRO B 1 354 ? -43.757 42.406  9.436  1.00 26.74  ? 333  PRO B O     1 ? 
ATOM   6737 C CB    . PRO B 1 354 ? -46.875 42.893  10.003 1.00 37.13  ? 333  PRO B CB    1 ? 
ATOM   6738 C CG    . PRO B 1 354 ? -47.990 42.135  10.731 1.00 40.44  ? 333  PRO B CG    1 ? 
ATOM   6739 C CD    . PRO B 1 354 ? -48.145 40.786  10.048 1.00 39.14  ? 333  PRO B CD    1 ? 
ATOM   6740 N N     . GLY B 1 355 ? -44.487 40.878  10.922 1.00 28.86  ? 334  GLY B N     1 ? 
ATOM   6741 C CA    . GLY B 1 355 ? -43.177 40.624  11.508 1.00 28.35  ? 334  GLY B CA    1 ? 
ATOM   6742 C C     . GLY B 1 355 ? -42.367 39.696  10.598 1.00 30.01  ? 334  GLY B C     1 ? 
ATOM   6743 O O     . GLY B 1 355 ? -42.595 38.481  10.598 1.00 28.13  ? 334  GLY B O     1 ? 
ATOM   6744 N N     . VAL B 1 356 ? -41.407 40.264  9.847  1.00 26.26  ? 335  VAL B N     1 ? 
ATOM   6745 C CA    . VAL B 1 356 ? -40.763 39.548  8.749  1.00 31.49  ? 335  VAL B CA    1 ? 
ATOM   6746 C C     . VAL B 1 356 ? -39.252 39.458  8.923  1.00 28.44  ? 335  VAL B C     1 ? 
ATOM   6747 O O     . VAL B 1 356 ? -38.631 38.552  8.364  1.00 29.93  ? 335  VAL B O     1 ? 
ATOM   6748 C CB    . VAL B 1 356 ? -41.057 40.137  7.353  1.00 30.97  ? 335  VAL B CB    1 ? 
ATOM   6749 C CG1   . VAL B 1 356 ? -42.476 39.884  6.913  1.00 33.68  ? 335  VAL B CG1   1 ? 
ATOM   6750 C CG2   . VAL B 1 356 ? -40.682 41.610  7.280  1.00 31.38  ? 335  VAL B CG2   1 ? 
ATOM   6751 N N     . ALA B 1 357 ? -38.647 40.379  9.677  1.00 29.16  ? 336  ALA B N     1 ? 
ATOM   6752 C CA    . ALA B 1 357 ? -37.208 40.376  9.847  1.00 29.12  ? 336  ALA B CA    1 ? 
ATOM   6753 C C     . ALA B 1 357 ? -36.818 40.444  11.317 1.00 26.66  ? 336  ALA B C     1 ? 
ATOM   6754 O O     . ALA B 1 357 ? -37.450 41.135  12.099 1.00 25.15  ? 336  ALA B O     1 ? 
ATOM   6755 C CB    . ALA B 1 357 ? -36.603 41.536  9.065  1.00 28.96  ? 336  ALA B CB    1 ? 
ATOM   6756 N N     . SER B 1 358 ? -35.703 39.796  11.659 1.00 26.69  ? 337  SER B N     1 ? 
ATOM   6757 C CA    . SER B 1 358 ? -35.169 39.867  13.005 1.00 26.85  ? 337  SER B CA    1 ? 
ATOM   6758 C C     . SER B 1 358 ? -33.666 40.121  12.970 1.00 25.61  ? 337  SER B C     1 ? 
ATOM   6759 O O     . SER B 1 358 ? -32.947 39.564  12.149 1.00 28.70  ? 337  SER B O     1 ? 
ATOM   6760 C CB    . SER B 1 358 ? -35.500 38.601  13.766 1.00 27.54  ? 337  SER B CB    1 ? 
ATOM   6761 O OG    . SER B 1 358 ? -34.752 38.491  14.969 1.00 32.02  ? 337  SER B OG    1 ? 
ATOM   6762 N N     . GLY B 1 359 ? -33.204 40.957  13.891 1.00 27.97  ? 338  GLY B N     1 ? 
ATOM   6763 C CA    . GLY B 1 359 ? -31.784 41.202  14.073 1.00 27.78  ? 338  GLY B CA    1 ? 
ATOM   6764 C C     . GLY B 1 359 ? -31.390 41.088  15.536 1.00 30.09  ? 338  GLY B C     1 ? 
ATOM   6765 O O     . GLY B 1 359 ? -32.181 41.449  16.416 1.00 31.68  ? 338  GLY B O     1 ? 
ATOM   6766 N N     . PHE B 1 360 ? -30.154 40.616  15.767 1.00 29.92  ? 339  PHE B N     1 ? 
ATOM   6767 C CA    . PHE B 1 360 ? -29.608 40.486  17.103 1.00 29.51  ? 339  PHE B CA    1 ? 
ATOM   6768 C C     . PHE B 1 360 ? -28.474 41.483  17.315 1.00 31.36  ? 339  PHE B C     1 ? 
ATOM   6769 O O     . PHE B 1 360 ? -27.633 41.647  16.431 1.00 31.37  ? 339  PHE B O     1 ? 
ATOM   6770 C CB    . PHE B 1 360 ? -29.163 39.033  17.238 1.00 30.12  ? 339  PHE B CB    1 ? 
ATOM   6771 C CG    . PHE B 1 360 ? -30.361 38.106  17.262 1.00 33.32  ? 339  PHE B CG    1 ? 
ATOM   6772 C CD1   . PHE B 1 360 ? -30.976 37.698  16.074 1.00 37.61  ? 339  PHE B CD1   1 ? 
ATOM   6773 C CD2   . PHE B 1 360 ? -30.929 37.737  18.474 1.00 32.13  ? 339  PHE B CD2   1 ? 
ATOM   6774 C CE1   . PHE B 1 360 ? -32.101 36.888  16.111 1.00 36.44  ? 339  PHE B CE1   1 ? 
ATOM   6775 C CE2   . PHE B 1 360 ? -32.043 36.918  18.510 1.00 29.01  ? 339  PHE B CE2   1 ? 
ATOM   6776 C CZ    . PHE B 1 360 ? -32.630 36.499  17.338 1.00 34.35  ? 339  PHE B CZ    1 ? 
ATOM   6777 N N     . VAL B 1 361 ? -28.448 42.107  18.497 1.00 30.38  ? 340  VAL B N     1 ? 
ATOM   6778 C CA    . VAL B 1 361 ? -27.513 43.186  18.789 1.00 32.98  ? 340  VAL B CA    1 ? 
ATOM   6779 C C     . VAL B 1 361 ? -26.798 42.966  20.121 1.00 34.39  ? 340  VAL B C     1 ? 
ATOM   6780 O O     . VAL B 1 361 ? -27.229 42.194  20.972 1.00 33.92  ? 340  VAL B O     1 ? 
ATOM   6781 C CB    . VAL B 1 361 ? -28.216 44.548  18.791 1.00 29.27  ? 340  VAL B CB    1 ? 
ATOM   6782 C CG1   . VAL B 1 361 ? -28.935 44.787  17.482 1.00 30.23  ? 340  VAL B CG1   1 ? 
ATOM   6783 C CG2   . VAL B 1 361 ? -29.166 44.691  19.976 1.00 31.84  ? 340  VAL B CG2   1 ? 
ATOM   6784 N N     . SER B 1 362 ? -25.682 43.683  20.278 1.00 34.48  ? 341  SER B N     1 ? 
ATOM   6785 C CA    . SER B 1 362 ? -24.937 43.753  21.529 1.00 41.98  ? 341  SER B CA    1 ? 
ATOM   6786 C C     . SER B 1 362 ? -24.912 45.217  21.945 1.00 44.29  ? 341  SER B C     1 ? 
ATOM   6787 O O     . SER B 1 362 ? -24.061 45.963  21.475 1.00 44.15  ? 341  SER B O     1 ? 
ATOM   6788 C CB    . SER B 1 362 ? -23.520 43.189  21.382 1.00 40.52  ? 341  SER B CB    1 ? 
ATOM   6789 O OG    . SER B 1 362 ? -22.700 43.387  22.533 1.00 43.91  ? 341  SER B OG    1 ? 
ATOM   6790 N N     . SER B 1 363 ? -25.868 45.623  22.784 1.00 41.73  ? 342  SER B N     1 ? 
ATOM   6791 C CA    . SER B 1 363 ? -26.139 47.034  23.000 1.00 44.96  ? 342  SER B CA    1 ? 
ATOM   6792 C C     . SER B 1 363 ? -24.966 47.757  23.678 1.00 51.26  ? 342  SER B C     1 ? 
ATOM   6793 O O     . SER B 1 363 ? -24.943 48.985  23.676 1.00 51.48  ? 342  SER B O     1 ? 
ATOM   6794 C CB    . SER B 1 363 ? -27.413 47.227  23.761 1.00 40.20  ? 342  SER B CB    1 ? 
ATOM   6795 O OG    . SER B 1 363 ? -27.265 46.808  25.110 1.00 42.76  ? 342  SER B OG    1 ? 
ATOM   6796 N N     . ASP B 1 364 ? -24.006 47.005  24.246 1.00 47.25  ? 343  ASP B N     1 ? 
ATOM   6797 C CA    . ASP B 1 364 ? -22.854 47.577  24.933 1.00 49.98  ? 343  ASP B CA    1 ? 
ATOM   6798 C C     . ASP B 1 364 ? -21.562 47.284  24.170 1.00 54.77  ? 343  ASP B C     1 ? 
ATOM   6799 O O     . ASP B 1 364 ? -20.470 47.519  24.684 1.00 61.96  ? 343  ASP B O     1 ? 
ATOM   6800 C CB    . ASP B 1 364 ? -22.729 47.048  26.352 1.00 44.76  ? 343  ASP B CB    1 ? 
ATOM   6801 C CG    . ASP B 1 364 ? -22.359 45.574  26.466 1.00 55.18  ? 343  ASP B CG    1 ? 
ATOM   6802 O OD1   . ASP B 1 364 ? -22.060 44.959  25.418 1.00 44.27  ? 343  ASP B OD1   1 ? 
ATOM   6803 O OD2   . ASP B 1 364 ? -22.384 45.038  27.599 1.00 51.23  ? 343  ASP B OD2   1 ? 
ATOM   6804 N N     . GLY B 1 365 ? -21.679 46.695  22.976 1.00 53.61  ? 344  GLY B N     1 ? 
ATOM   6805 C CA    . GLY B 1 365 ? -20.558 46.580  22.060 1.00 52.14  ? 344  GLY B CA    1 ? 
ATOM   6806 C C     . GLY B 1 365 ? -19.640 45.397  22.354 1.00 49.21  ? 344  GLY B C     1 ? 
ATOM   6807 O O     . GLY B 1 365 ? -18.796 45.091  21.524 1.00 60.44  ? 344  GLY B O     1 ? 
ATOM   6808 N N     . THR B 1 366 ? -19.790 44.723  23.503 1.00 49.56  ? 345  THR B N     1 ? 
ATOM   6809 C CA    . THR B 1 366 ? -18.812 43.729  23.933 1.00 52.73  ? 345  THR B CA    1 ? 
ATOM   6810 C C     . THR B 1 366 ? -18.927 42.439  23.123 1.00 52.98  ? 345  THR B C     1 ? 
ATOM   6811 O O     . THR B 1 366 ? -18.025 41.602  23.170 1.00 56.11  ? 345  THR B O     1 ? 
ATOM   6812 C CB    . THR B 1 366 ? -18.919 43.413  25.430 1.00 55.38  ? 345  THR B CB    1 ? 
ATOM   6813 O OG1   . THR B 1 366 ? -20.153 42.735  25.645 1.00 55.94  ? 345  THR B OG1   1 ? 
ATOM   6814 C CG2   . THR B 1 366 ? -18.791 44.652  26.301 1.00 57.20  ? 345  THR B CG2   1 ? 
ATOM   6815 N N     . LYS B 1 367 ? -20.055 42.240  22.434 1.00 48.53  ? 346  LYS B N     1 ? 
ATOM   6816 C CA    . LYS B 1 367 ? -20.267 41.025  21.667 1.00 45.63  ? 346  LYS B CA    1 ? 
ATOM   6817 C C     . LYS B 1 367 ? -19.956 39.796  22.514 1.00 45.74  ? 346  LYS B C     1 ? 
ATOM   6818 O O     . LYS B 1 367 ? -19.269 38.893  22.053 1.00 48.31  ? 346  LYS B O     1 ? 
ATOM   6819 C CB    . LYS B 1 367 ? -19.444 41.037  20.376 1.00 45.89  ? 346  LYS B CB    1 ? 
ATOM   6820 C CG    . LYS B 1 367 ? -19.910 42.063  19.349 1.00 50.65  ? 346  LYS B CG    1 ? 
ATOM   6821 C CD    . LYS B 1 367 ? -19.239 41.960  17.990 1.00 55.39  ? 346  LYS B CD    1 ? 
ATOM   6822 C CE    . LYS B 1 367 ? -20.044 42.653  16.951 1.00 57.67  ? 346  LYS B CE    1 ? 
ATOM   6823 N NZ    . LYS B 1 367 ? -19.418 42.391  15.660 1.00 62.69  ? 346  LYS B NZ    1 ? 
ATOM   6824 N N     . THR B 1 368 ? -20.527 39.737  23.725 1.00 51.53  ? 347  THR B N     1 ? 
ATOM   6825 C CA    . THR B 1 368 ? -20.403 38.574  24.591 1.00 53.44  ? 347  THR B CA    1 ? 
ATOM   6826 C C     . THR B 1 368 ? -21.741 37.835  24.666 1.00 52.72  ? 347  THR B C     1 ? 
ATOM   6827 O O     . THR B 1 368 ? -22.048 37.212  25.675 1.00 54.16  ? 347  THR B O     1 ? 
ATOM   6828 C CB    . THR B 1 368 ? -19.903 39.021  25.967 1.00 56.83  ? 347  THR B CB    1 ? 
ATOM   6829 O OG1   . THR B 1 368 ? -20.849 39.946  26.492 1.00 56.37  ? 347  THR B OG1   1 ? 
ATOM   6830 C CG2   . THR B 1 368 ? -18.554 39.720  25.891 1.00 54.16  ? 347  THR B CG2   1 ? 
ATOM   6831 N N     . GLY B 1 369 ? -22.500 37.853  23.563 1.00 46.39  ? 348  GLY B N     1 ? 
ATOM   6832 C CA    . GLY B 1 369 ? -23.832 37.268  23.517 1.00 41.60  ? 348  GLY B CA    1 ? 
ATOM   6833 C C     . GLY B 1 369 ? -24.860 38.360  23.249 1.00 37.22  ? 348  GLY B C     1 ? 
ATOM   6834 O O     . GLY B 1 369 ? -24.879 39.356  23.943 1.00 33.79  ? 348  GLY B O     1 ? 
ATOM   6835 N N     . ALA B 1 370 ? -25.712 38.201  22.234 1.00 36.76  ? 349  ALA B N     1 ? 
ATOM   6836 C CA    . ALA B 1 370 ? -26.713 39.223  21.978 1.00 33.70  ? 349  ALA B CA    1 ? 
ATOM   6837 C C     . ALA B 1 370 ? -27.546 39.442  23.246 1.00 31.92  ? 349  ALA B C     1 ? 
ATOM   6838 O O     . ALA B 1 370 ? -27.858 38.496  23.984 1.00 31.77  ? 349  ALA B O     1 ? 
ATOM   6839 C CB    . ALA B 1 370 ? -27.557 38.838  20.784 1.00 34.40  ? 349  ALA B CB    1 ? 
ATOM   6840 N N     . ASP B 1 371 ? -27.887 40.706  23.513 1.00 30.11  ? 350  ASP B N     1 ? 
ATOM   6841 C CA    . ASP B 1 371 ? -28.642 41.075  24.699 1.00 28.68  ? 350  ASP B CA    1 ? 
ATOM   6842 C C     . ASP B 1 371 ? -30.074 41.462  24.309 1.00 28.07  ? 350  ASP B C     1 ? 
ATOM   6843 O O     . ASP B 1 371 ? -30.974 41.331  25.138 1.00 25.30  ? 350  ASP B O     1 ? 
ATOM   6844 C CB    . ASP B 1 371 ? -27.867 42.068  25.564 1.00 29.55  ? 350  ASP B CB    1 ? 
ATOM   6845 C CG    . ASP B 1 371 ? -27.498 43.401  24.934 1.00 29.07  ? 350  ASP B CG    1 ? 
ATOM   6846 O OD1   . ASP B 1 371 ? -27.596 43.524  23.705 1.00 30.40  ? 350  ASP B OD1   1 ? 
ATOM   6847 O OD2   . ASP B 1 371 ? -27.168 44.336  25.690 1.00 30.26  ? 350  ASP B OD2   1 ? 
ATOM   6848 N N     . PHE B 1 372 ? -30.273 41.903  23.052 1.00 26.33  ? 351  PHE B N     1 ? 
ATOM   6849 C CA    . PHE B 1 372 ? -31.578 42.266  22.519 1.00 26.12  ? 351  PHE B CA    1 ? 
ATOM   6850 C C     . PHE B 1 372 ? -31.783 41.654  21.135 1.00 26.56  ? 351  PHE B C     1 ? 
ATOM   6851 O O     . PHE B 1 372 ? -30.836 41.486  20.349 1.00 27.10  ? 351  PHE B O     1 ? 
ATOM   6852 C CB    . PHE B 1 372 ? -31.850 43.772  22.461 1.00 26.33  ? 351  PHE B CB    1 ? 
ATOM   6853 C CG    . PHE B 1 372 ? -31.798 44.389  23.851 1.00 29.80  ? 351  PHE B CG    1 ? 
ATOM   6854 C CD1   . PHE B 1 372 ? -32.924 44.428  24.670 1.00 31.97  ? 351  PHE B CD1   1 ? 
ATOM   6855 C CD2   . PHE B 1 372 ? -30.600 44.878  24.358 1.00 32.19  ? 351  PHE B CD2   1 ? 
ATOM   6856 C CE1   . PHE B 1 372 ? -32.852 44.968  25.944 1.00 32.45  ? 351  PHE B CE1   1 ? 
ATOM   6857 C CE2   . PHE B 1 372 ? -30.529 45.402  25.642 1.00 32.26  ? 351  PHE B CE2   1 ? 
ATOM   6858 C CZ    . PHE B 1 372 ? -31.652 45.445  26.433 1.00 33.72  ? 351  PHE B CZ    1 ? 
ATOM   6859 N N     . GLU B 1 373 ? -33.042 41.291  20.876 1.00 24.65  ? 352  GLU B N     1 ? 
ATOM   6860 C CA    . GLU B 1 373 ? -33.532 40.971  19.543 1.00 25.54  ? 352  GLU B CA    1 ? 
ATOM   6861 C C     . GLU B 1 373 ? -34.457 42.092  19.098 1.00 25.81  ? 352  GLU B C     1 ? 
ATOM   6862 O O     . GLU B 1 373 ? -35.282 42.562  19.887 1.00 28.79  ? 352  GLU B O     1 ? 
ATOM   6863 C CB    . GLU B 1 373 ? -34.261 39.622  19.537 1.00 25.08  ? 352  GLU B CB    1 ? 
ATOM   6864 C CG    . GLU B 1 373 ? -34.886 39.234  18.195 1.00 27.09  ? 352  GLU B CG    1 ? 
ATOM   6865 C CD    . GLU B 1 373 ? -35.617 37.896  18.209 1.00 28.68  ? 352  GLU B CD    1 ? 
ATOM   6866 O OE1   . GLU B 1 373 ? -36.080 37.434  17.132 1.00 33.94  ? 352  GLU B OE1   1 ? 
ATOM   6867 O OE2   . GLU B 1 373 ? -35.713 37.304  19.291 1.00 27.11  ? 352  GLU B OE2   1 ? 
ATOM   6868 N N     . LEU B 1 374 ? -34.310 42.510  17.835 1.00 23.69  ? 353  LEU B N     1 ? 
ATOM   6869 C CA    . LEU B 1 374 ? -35.162 43.525  17.248 1.00 26.34  ? 353  LEU B CA    1 ? 
ATOM   6870 C C     . LEU B 1 374 ? -35.959 42.846  16.135 1.00 28.08  ? 353  LEU B C     1 ? 
ATOM   6871 O O     . LEU B 1 374 ? -35.356 42.286  15.211 1.00 27.06  ? 353  LEU B O     1 ? 
ATOM   6872 C CB    . LEU B 1 374 ? -34.388 44.716  16.670 1.00 29.02  ? 353  LEU B CB    1 ? 
ATOM   6873 C CG    . LEU B 1 374 ? -33.271 45.342  17.512 1.00 30.47  ? 353  LEU B CG    1 ? 
ATOM   6874 C CD1   . LEU B 1 374 ? -32.853 46.669  16.854 1.00 30.76  ? 353  LEU B CD1   1 ? 
ATOM   6875 C CD2   . LEU B 1 374 ? -33.544 45.546  18.979 1.00 31.24  ? 353  LEU B CD2   1 ? 
ATOM   6876 N N     . ILE B 1 375 ? -37.296 42.875  16.239 1.00 27.69  ? 354  ILE B N     1 ? 
ATOM   6877 C CA    . ILE B 1 375 ? -38.140 42.283  15.214 1.00 25.55  ? 354  ILE B CA    1 ? 
ATOM   6878 C C     . ILE B 1 375 ? -38.818 43.413  14.465 1.00 25.20  ? 354  ILE B C     1 ? 
ATOM   6879 O O     . ILE B 1 375 ? -39.386 44.288  15.096 1.00 24.57  ? 354  ILE B O     1 ? 
ATOM   6880 C CB    . ILE B 1 375 ? -39.132 41.278  15.818 1.00 27.78  ? 354  ILE B CB    1 ? 
ATOM   6881 C CG1   . ILE B 1 375 ? -38.376 40.135  16.520 1.00 27.40  ? 354  ILE B CG1   1 ? 
ATOM   6882 C CG2   . ILE B 1 375 ? -40.098 40.767  14.741 1.00 27.03  ? 354  ILE B CG2   1 ? 
ATOM   6883 C CD1   . ILE B 1 375 ? -39.267 39.109  17.199 1.00 29.31  ? 354  ILE B CD1   1 ? 
ATOM   6884 N N     . PHE B 1 376 ? -38.766 43.381  13.127 1.00 24.45  ? 355  PHE B N     1 ? 
ATOM   6885 C CA    . PHE B 1 376 ? -39.192 44.518  12.311 1.00 25.61  ? 355  PHE B CA    1 ? 
ATOM   6886 C C     . PHE B 1 376 ? -40.465 44.195  11.532 1.00 22.87  ? 355  PHE B C     1 ? 
ATOM   6887 O O     . PHE B 1 376 ? -40.582 43.094  10.986 1.00 22.76  ? 355  PHE B O     1 ? 
ATOM   6888 C CB    . PHE B 1 376 ? -38.081 44.867  11.315 1.00 27.45  ? 355  PHE B CB    1 ? 
ATOM   6889 C CG    . PHE B 1 376 ? -36.806 45.377  11.956 1.00 25.78  ? 355  PHE B CG    1 ? 
ATOM   6890 C CD1   . PHE B 1 376 ? -35.867 44.513  12.469 1.00 26.43  ? 355  PHE B CD1   1 ? 
ATOM   6891 C CD2   . PHE B 1 376 ? -36.542 46.731  12.001 1.00 28.23  ? 355  PHE B CD2   1 ? 
ATOM   6892 C CE1   . PHE B 1 376 ? -34.715 44.997  13.072 1.00 26.45  ? 355  PHE B CE1   1 ? 
ATOM   6893 C CE2   . PHE B 1 376 ? -35.379 47.208  12.578 1.00 28.35  ? 355  PHE B CE2   1 ? 
ATOM   6894 C CZ    . PHE B 1 376 ? -34.476 46.338  13.117 1.00 27.20  ? 355  PHE B CZ    1 ? 
ATOM   6895 N N     . THR B 1 377 ? -41.402 45.169  11.470 1.00 25.69  ? 356  THR B N     1 ? 
ATOM   6896 C CA    . THR B 1 377 ? -42.533 45.134  10.557 1.00 25.45  ? 356  THR B CA    1 ? 
ATOM   6897 C C     . THR B 1 377 ? -42.503 46.378  9.668  1.00 28.54  ? 356  THR B C     1 ? 
ATOM   6898 O O     . THR B 1 377 ? -41.922 47.394  10.043 1.00 25.35  ? 356  THR B O     1 ? 
ATOM   6899 C CB    . THR B 1 377 ? -43.875 45.112  11.285 1.00 28.01  ? 356  THR B CB    1 ? 
ATOM   6900 O OG1   . THR B 1 377 ? -44.016 46.462  11.727 1.00 29.26  ? 356  THR B OG1   1 ? 
ATOM   6901 C CG2   . THR B 1 377 ? -43.949 44.143  12.450 1.00 29.10  ? 356  THR B CG2   1 ? 
ATOM   6902 N N     . TYR B 1 378 ? -43.255 46.296  8.559  1.00 27.51  ? 357  TYR B N     1 ? 
ATOM   6903 C CA    . TYR B 1 378 ? -43.333 47.345  7.548  1.00 30.36  ? 357  TYR B CA    1 ? 
ATOM   6904 C C     . TYR B 1 378 ? -44.662 48.094  7.691  1.00 33.36  ? 357  TYR B C     1 ? 
ATOM   6905 O O     . TYR B 1 378 ? -45.149 48.698  6.730  1.00 31.67  ? 357  TYR B O     1 ? 
ATOM   6906 C CB    . TYR B 1 378 ? -43.145 46.750  6.142  1.00 29.68  ? 357  TYR B CB    1 ? 
ATOM   6907 C CG    . TYR B 1 378 ? -44.011 45.532  5.875  1.00 26.74  ? 357  TYR B CG    1 ? 
ATOM   6908 C CD1   . TYR B 1 378 ? -45.350 45.672  5.537  1.00 29.32  ? 357  TYR B CD1   1 ? 
ATOM   6909 C CD2   . TYR B 1 378 ? -43.501 44.241  5.985  1.00 27.79  ? 357  TYR B CD2   1 ? 
ATOM   6910 C CE1   . TYR B 1 378 ? -46.155 44.560  5.346  1.00 27.69  ? 357  TYR B CE1   1 ? 
ATOM   6911 C CE2   . TYR B 1 378 ? -44.295 43.124  5.783  1.00 24.65  ? 357  TYR B CE2   1 ? 
ATOM   6912 C CZ    . TYR B 1 378 ? -45.627 43.287  5.485  1.00 25.82  ? 357  TYR B CZ    1 ? 
ATOM   6913 O OH    . TYR B 1 378 ? -46.412 42.205  5.263  1.00 27.07  ? 357  TYR B OH    1 ? 
ATOM   6914 N N     . THR B 1 379 ? -45.226 48.044  8.908  1.00 31.08  ? 358  THR B N     1 ? 
ATOM   6915 C CA    . THR B 1 379 ? -46.449 48.732  9.309  1.00 30.95  ? 358  THR B CA    1 ? 
ATOM   6916 C C     . THR B 1 379 ? -46.222 49.366  10.680 1.00 28.55  ? 358  THR B C     1 ? 
ATOM   6917 O O     . THR B 1 379 ? -45.427 48.857  11.463 1.00 28.08  ? 358  THR B O     1 ? 
ATOM   6918 C CB    . THR B 1 379 ? -47.604 47.731  9.373  1.00 29.76  ? 358  THR B CB    1 ? 
ATOM   6919 O OG1   . THR B 1 379 ? -47.247 46.695  10.285 1.00 31.04  ? 358  THR B OG1   1 ? 
ATOM   6920 C CG2   . THR B 1 379 ? -47.962 47.147  8.019  1.00 31.13  ? 358  THR B CG2   1 ? 
ATOM   6921 N N     . HIS B 1 380 ? -46.920 50.459  11.005 1.00 26.19  ? 359  HIS B N     1 ? 
ATOM   6922 C CA    . HIS B 1 380 ? -46.738 51.055  12.330 1.00 28.86  ? 359  HIS B CA    1 ? 
ATOM   6923 C C     . HIS B 1 380 ? -47.259 50.154  13.466 1.00 30.96  ? 359  HIS B C     1 ? 
ATOM   6924 O O     . HIS B 1 380 ? -46.777 50.275  14.588 1.00 34.63  ? 359  HIS B O     1 ? 
ATOM   6925 C CB    . HIS B 1 380 ? -47.365 52.439  12.464 1.00 28.91  ? 359  HIS B CB    1 ? 
ATOM   6926 C CG    . HIS B 1 380 ? -48.753 52.489  11.953 1.00 32.52  ? 359  HIS B CG    1 ? 
ATOM   6927 N ND1   . HIS B 1 380 ? -49.104 53.259  10.870 1.00 35.33  ? 359  HIS B ND1   1 ? 
ATOM   6928 C CD2   . HIS B 1 380 ? -49.875 51.877  12.351 1.00 31.24  ? 359  HIS B CD2   1 ? 
ATOM   6929 C CE1   . HIS B 1 380 ? -50.394 53.106  10.623 1.00 30.65  ? 359  HIS B CE1   1 ? 
ATOM   6930 N NE2   . HIS B 1 380 ? -50.878 52.253  11.487 1.00 38.71  ? 359  HIS B NE2   1 ? 
ATOM   6931 N N     . GLY B 1 381 ? -48.276 49.317  13.191 1.00 31.90  ? 360  GLY B N     1 ? 
ATOM   6932 C CA    . GLY B 1 381 ? -48.874 48.448  14.196 1.00 36.48  ? 360  GLY B CA    1 ? 
ATOM   6933 C C     . GLY B 1 381 ? -49.563 49.224  15.319 1.00 38.03  ? 360  GLY B C     1 ? 
ATOM   6934 O O     . GLY B 1 381 ? -49.668 48.727  16.436 1.00 33.35  ? 360  GLY B O     1 ? 
ATOM   6935 N N     . ALA B 1 382 ? -50.047 50.438  15.025 1.00 34.90  ? 361  ALA B N     1 ? 
ATOM   6936 C CA    . ALA B 1 382 ? -50.638 51.295  16.035 1.00 38.63  ? 361  ALA B CA    1 ? 
ATOM   6937 C C     . ALA B 1 382 ? -52.098 50.895  16.211 1.00 42.27  ? 361  ALA B C     1 ? 
ATOM   6938 O O     . ALA B 1 382 ? -52.737 50.496  15.247 1.00 45.78  ? 361  ALA B O     1 ? 
ATOM   6939 C CB    . ALA B 1 382 ? -50.504 52.751  15.635 1.00 38.64  ? 361  ALA B CB    1 ? 
ATOM   6940 N N     . ASP B 1 383 ? -52.612 50.960  17.440 1.00 47.30  ? 362  ASP B N     1 ? 
ATOM   6941 C CA    . ASP B 1 383 ? -54.052 51.138  17.655 1.00 53.90  ? 362  ASP B CA    1 ? 
ATOM   6942 C C     . ASP B 1 383 ? -54.275 52.654  17.684 1.00 53.73  ? 362  ASP B C     1 ? 
ATOM   6943 O O     . ASP B 1 383 ? -53.389 53.393  17.276 1.00 66.01  ? 362  ASP B O     1 ? 
ATOM   6944 C CB    . ASP B 1 383 ? -54.524 50.339  18.863 1.00 51.53  ? 362  ASP B CB    1 ? 
ATOM   6945 C CG    . ASP B 1 383 ? -53.754 50.646  20.133 1.00 50.68  ? 362  ASP B CG    1 ? 
ATOM   6946 O OD1   . ASP B 1 383 ? -53.627 51.837  20.444 1.00 54.71  ? 362  ASP B OD1   1 ? 
ATOM   6947 O OD2   . ASP B 1 383 ? -53.259 49.709  20.766 1.00 48.10  ? 362  ASP B OD2   1 ? 
ATOM   6948 N N     . GLY B 1 384 ? -55.414 53.155  18.167 1.00 64.64  ? 363  GLY B N     1 ? 
ATOM   6949 C CA    . GLY B 1 384 ? -55.612 54.599  18.281 1.00 61.16  ? 363  GLY B CA    1 ? 
ATOM   6950 C C     . GLY B 1 384 ? -55.177 55.163  19.642 1.00 54.86  ? 363  GLY B C     1 ? 
ATOM   6951 O O     . GLY B 1 384 ? -55.353 56.342  19.902 1.00 62.80  ? 363  GLY B O     1 ? 
ATOM   6952 N N     . THR B 1 385 ? -54.553 54.318  20.466 1.00 56.49  ? 364  THR B N     1 ? 
ATOM   6953 C CA    . THR B 1 385 ? -54.300 54.545  21.886 1.00 54.23  ? 364  THR B CA    1 ? 
ATOM   6954 C C     . THR B 1 385 ? -53.104 55.458  22.105 1.00 48.12  ? 364  THR B C     1 ? 
ATOM   6955 O O     . THR B 1 385 ? -52.982 56.064  23.160 1.00 50.61  ? 364  THR B O     1 ? 
ATOM   6956 C CB    . THR B 1 385 ? -53.969 53.188  22.509 1.00 45.61  ? 364  THR B CB    1 ? 
ATOM   6957 O OG1   . THR B 1 385 ? -55.235 52.585  22.718 1.00 56.13  ? 364  THR B OG1   1 ? 
ATOM   6958 C CG2   . THR B 1 385 ? -53.123 53.232  23.770 1.00 45.04  ? 364  THR B CG2   1 ? 
ATOM   6959 N N     . GLU B 1 386 ? -52.151 55.420  21.179 1.00 43.21  ? 365  GLU B N     1 ? 
ATOM   6960 C CA    . GLU B 1 386 ? -50.848 55.983  21.476 1.00 41.73  ? 365  GLU B CA    1 ? 
ATOM   6961 C C     . GLU B 1 386 ? -51.000 57.504  21.547 1.00 41.79  ? 365  GLU B C     1 ? 
ATOM   6962 O O     . GLU B 1 386 ? -51.447 58.128  20.591 1.00 41.76  ? 365  GLU B O     1 ? 
ATOM   6963 C CB    . GLU B 1 386 ? -49.800 55.525  20.461 1.00 38.14  ? 365  GLU B CB    1 ? 
ATOM   6964 C CG    . GLU B 1 386 ? -49.693 54.012  20.295 1.00 35.75  ? 365  GLU B CG    1 ? 
ATOM   6965 C CD    . GLU B 1 386 ? -50.701 53.332  19.382 1.00 32.88  ? 365  GLU B CD    1 ? 
ATOM   6966 O OE1   . GLU B 1 386 ? -51.584 54.055  18.867 1.00 32.08  ? 365  GLU B OE1   1 ? 
ATOM   6967 O OE2   . GLU B 1 386 ? -50.590 52.104  19.137 1.00 34.87  ? 365  GLU B OE2   1 ? 
ATOM   6968 N N     . LYS B 1 387 ? -50.614 58.091  22.685 1.00 40.11  ? 366  LYS B N     1 ? 
ATOM   6969 C CA    . LYS B 1 387 ? -50.763 59.520  22.921 1.00 42.04  ? 366  LYS B CA    1 ? 
ATOM   6970 C C     . LYS B 1 387 ? -50.052 60.332  21.841 1.00 42.62  ? 366  LYS B C     1 ? 
ATOM   6971 O O     . LYS B 1 387 ? -50.562 61.366  21.433 1.00 40.95  ? 366  LYS B O     1 ? 
ATOM   6972 C CB    . LYS B 1 387 ? -50.244 59.913  24.307 1.00 45.15  ? 366  LYS B CB    1 ? 
ATOM   6973 C CG    . LYS B 1 387 ? -51.022 59.236  25.440 1.00 49.64  ? 366  LYS B CG    1 ? 
ATOM   6974 C CD    . LYS B 1 387 ? -50.891 59.848  26.828 1.00 57.08  ? 366  LYS B CD    1 ? 
ATOM   6975 C CE    . LYS B 1 387 ? -49.503 59.794  27.408 1.00 64.56  ? 366  LYS B CE    1 ? 
ATOM   6976 N NZ    . LYS B 1 387 ? -49.512 60.015  28.860 1.00 63.61  ? 366  LYS B NZ    1 ? 
ATOM   6977 N N     . GLU B 1 388 ? -48.897 59.857  21.363 1.00 38.02  ? 367  GLU B N     1 ? 
ATOM   6978 C CA    . GLU B 1 388 ? -48.106 60.600  20.393 1.00 38.82  ? 367  GLU B CA    1 ? 
ATOM   6979 C C     . GLU B 1 388 ? -48.789 60.662  19.023 1.00 38.93  ? 367  GLU B C     1 ? 
ATOM   6980 O O     . GLU B 1 388 ? -48.409 61.474  18.181 1.00 39.04  ? 367  GLU B O     1 ? 
ATOM   6981 C CB    . GLU B 1 388 ? -46.725 59.992  20.190 1.00 39.03  ? 367  GLU B CB    1 ? 
ATOM   6982 C CG    . GLU B 1 388 ? -45.903 59.838  21.466 1.00 41.16  ? 367  GLU B CG    1 ? 
ATOM   6983 C CD    . GLU B 1 388 ? -46.224 58.624  22.326 1.00 42.55  ? 367  GLU B CD    1 ? 
ATOM   6984 O OE1   . GLU B 1 388 ? -45.504 58.491  23.326 1.00 46.19  ? 367  GLU B OE1   1 ? 
ATOM   6985 O OE2   . GLU B 1 388 ? -47.137 57.830  22.019 1.00 40.77  ? 367  GLU B OE2   1 ? 
ATOM   6986 N N     . PHE B 1 389 ? -49.768 59.785  18.787 1.00 38.12  ? 368  PHE B N     1 ? 
ATOM   6987 C CA    . PHE B 1 389 ? -50.457 59.696  17.509 1.00 40.43  ? 368  PHE B CA    1 ? 
ATOM   6988 C C     . PHE B 1 389 ? -51.881 60.250  17.620 1.00 42.45  ? 368  PHE B C     1 ? 
ATOM   6989 O O     . PHE B 1 389 ? -52.720 59.998  16.752 1.00 39.70  ? 368  PHE B O     1 ? 
ATOM   6990 C CB    . PHE B 1 389 ? -50.528 58.223  17.080 1.00 36.70  ? 368  PHE B CB    1 ? 
ATOM   6991 C CG    . PHE B 1 389 ? -49.198 57.488  16.953 1.00 32.55  ? 368  PHE B CG    1 ? 
ATOM   6992 C CD1   . PHE B 1 389 ? -48.001 58.171  16.773 1.00 33.61  ? 368  PHE B CD1   1 ? 
ATOM   6993 C CD2   . PHE B 1 389 ? -49.150 56.100  16.997 1.00 34.68  ? 368  PHE B CD2   1 ? 
ATOM   6994 C CE1   . PHE B 1 389 ? -46.796 57.486  16.663 1.00 33.83  ? 368  PHE B CE1   1 ? 
ATOM   6995 C CE2   . PHE B 1 389 ? -47.943 55.423  16.888 1.00 30.92  ? 368  PHE B CE2   1 ? 
ATOM   6996 C CZ    . PHE B 1 389 ? -46.771 56.112  16.724 1.00 33.68  ? 368  PHE B CZ    1 ? 
ATOM   6997 N N     . ALA B 1 390 ? -52.162 60.996  18.697 1.00 41.87  ? 369  ALA B N     1 ? 
ATOM   6998 C CA    . ALA B 1 390 ? -53.523 61.388  19.028 1.00 52.17  ? 369  ALA B CA    1 ? 
ATOM   6999 C C     . ALA B 1 390 ? -54.158 62.200  17.894 1.00 55.73  ? 369  ALA B C     1 ? 
ATOM   7000 O O     . ALA B 1 390 ? -55.348 62.048  17.621 1.00 61.57  ? 369  ALA B O     1 ? 
ATOM   7001 C CB    . ALA B 1 390 ? -53.541 62.161  20.334 1.00 57.61  ? 369  ALA B CB    1 ? 
ATOM   7002 N N     . ASN B 1 391 ? -53.354 63.023  17.211 1.00 57.07  ? 370  ASN B N     1 ? 
ATOM   7003 C CA    . ASN B 1 391 ? -53.880 63.997  16.268 1.00 61.46  ? 370  ASN B CA    1 ? 
ATOM   7004 C C     . ASN B 1 391 ? -53.792 63.515  14.823 1.00 59.19  ? 370  ASN B C     1 ? 
ATOM   7005 O O     . ASN B 1 391 ? -54.017 64.309  13.915 1.00 58.50  ? 370  ASN B O     1 ? 
ATOM   7006 C CB    . ASN B 1 391 ? -53.171 65.335  16.433 1.00 59.11  ? 370  ASN B CB    1 ? 
ATOM   7007 C CG    . ASN B 1 391 ? -53.308 65.840  17.846 1.00 61.41  ? 370  ASN B CG    1 ? 
ATOM   7008 O OD1   . ASN B 1 391 ? -54.417 65.842  18.391 1.00 61.59  ? 370  ASN B OD1   1 ? 
ATOM   7009 N ND2   . ASN B 1 391 ? -52.199 66.223  18.464 1.00 65.56  ? 370  ASN B ND2   1 ? 
ATOM   7010 N N     . ILE B 1 392 ? -53.482 62.228  14.611 1.00 58.80  ? 371  ILE B N     1 ? 
ATOM   7011 C CA    . ILE B 1 392 ? -53.385 61.677  13.267 1.00 52.38  ? 371  ILE B CA    1 ? 
ATOM   7012 C C     . ILE B 1 392 ? -54.781 61.316  12.771 1.00 56.83  ? 371  ILE B C     1 ? 
ATOM   7013 O O     . ILE B 1 392 ? -55.532 60.664  13.483 1.00 59.32  ? 371  ILE B O     1 ? 
ATOM   7014 C CB    . ILE B 1 392 ? -52.434 60.465  13.243 1.00 50.84  ? 371  ILE B CB    1 ? 
ATOM   7015 C CG1   . ILE B 1 392 ? -50.996 60.898  13.543 1.00 49.61  ? 371  ILE B CG1   1 ? 
ATOM   7016 C CG2   . ILE B 1 392 ? -52.544 59.718  11.915 1.00 50.15  ? 371  ILE B CG2   1 ? 
ATOM   7017 C CD1   . ILE B 1 392 ? -49.992 59.771  13.646 1.00 50.81  ? 371  ILE B CD1   1 ? 
ATOM   7018 N N     . GLU B 1 393 ? -55.110 61.713  11.534 1.00 58.03  ? 372  GLU B N     1 ? 
ATOM   7019 C CA    . GLU B 1 393 ? -56.341 61.278  10.888 1.00 62.91  ? 372  GLU B CA    1 ? 
ATOM   7020 C C     . GLU B 1 393 ? -56.120 59.913  10.239 1.00 56.28  ? 372  GLU B C     1 ? 
ATOM   7021 O O     . GLU B 1 393 ? -55.098 59.694  9.596  1.00 57.77  ? 372  GLU B O     1 ? 
ATOM   7022 C CB    . GLU B 1 393 ? -56.815 62.200  9.759  1.00 69.52  ? 372  GLU B CB    1 ? 
ATOM   7023 C CG    . GLU B 1 393 ? -57.427 63.530  10.192 1.00 74.07  ? 372  GLU B CG    1 ? 
ATOM   7024 C CD    . GLU B 1 393 ? -58.017 64.317  9.022  1.00 78.24  ? 372  GLU B CD    1 ? 
ATOM   7025 O OE1   . GLU B 1 393 ? -58.125 65.558  9.152  1.00 75.76  ? 372  GLU B OE1   1 ? 
ATOM   7026 O OE2   . GLU B 1 393 ? -58.383 63.708  7.981  1.00 72.24  ? 372  GLU B OE2   1 ? 
ATOM   7027 N N     . ASP B 1 394 ? -57.100 59.019  10.397 1.00 54.97  ? 373  ASP B N     1 ? 
ATOM   7028 C CA    . ASP B 1 394 ? -57.140 57.760  9.672  1.00 62.61  ? 373  ASP B CA    1 ? 
ATOM   7029 C C     . ASP B 1 394 ? -55.788 57.061  9.832  1.00 56.94  ? 373  ASP B C     1 ? 
ATOM   7030 O O     . ASP B 1 394 ? -55.106 56.786  8.850  1.00 48.24  ? 373  ASP B O     1 ? 
ATOM   7031 C CB    . ASP B 1 394 ? -57.585 57.995  8.231  1.00 65.97  ? 373  ASP B CB    1 ? 
ATOM   7032 C CG    . ASP B 1 394 ? -58.091 56.773  7.475  1.00 72.56  ? 373  ASP B CG    1 ? 
ATOM   7033 O OD1   . ASP B 1 394 ? -58.257 55.714  8.122  1.00 74.36  ? 373  ASP B OD1   1 ? 
ATOM   7034 O OD2   . ASP B 1 394 ? -58.318 56.889  6.245  1.00 74.02  ? 373  ASP B OD2   1 ? 
ATOM   7035 N N     . ILE B 1 395 ? -55.413 56.793  11.094 1.00 54.58  ? 374  ILE B N     1 ? 
ATOM   7036 C CA    . ILE B 1 395 ? -54.135 56.189  11.449 1.00 44.64  ? 374  ILE B CA    1 ? 
ATOM   7037 C C     . ILE B 1 395 ? -53.945 54.903  10.651 1.00 42.00  ? 374  ILE B C     1 ? 
ATOM   7038 O O     . ILE B 1 395 ? -52.866 54.664  10.116 1.00 38.31  ? 374  ILE B O     1 ? 
ATOM   7039 C CB    . ILE B 1 395 ? -54.042 55.949  12.977 1.00 47.20  ? 374  ILE B CB    1 ? 
ATOM   7040 C CG1   . ILE B 1 395 ? -52.657 55.446  13.423 1.00 46.46  ? 374  ILE B CG1   1 ? 
ATOM   7041 C CG2   . ILE B 1 395 ? -55.140 55.015  13.489 1.00 44.07  ? 374  ILE B CG2   1 ? 
ATOM   7042 C CD1   . ILE B 1 395 ? -51.731 56.541  13.912 1.00 46.71  ? 374  ILE B CD1   1 ? 
ATOM   7043 N N     . GLN B 1 396 ? -54.998 54.084  10.544 1.00 40.43  ? 375  GLN B N     1 ? 
ATOM   7044 C CA    . GLN B 1 396 ? -54.879 52.771  9.929  1.00 42.22  ? 375  GLN B CA    1 ? 
ATOM   7045 C C     . GLN B 1 396 ? -54.572 52.866  8.436  1.00 41.55  ? 375  GLN B C     1 ? 
ATOM   7046 O O     . GLN B 1 396 ? -54.124 51.890  7.853  1.00 42.94  ? 375  GLN B O     1 ? 
ATOM   7047 C CB    . GLN B 1 396 ? -56.146 51.932  10.099 1.00 49.05  ? 375  GLN B CB    1 ? 
ATOM   7048 C CG    . GLN B 1 396 ? -56.380 51.436  11.523 1.00 52.95  ? 375  GLN B CG    1 ? 
ATOM   7049 C CD    . GLN B 1 396 ? -55.142 50.837  12.163 1.00 56.30  ? 375  GLN B CD    1 ? 
ATOM   7050 O OE1   . GLN B 1 396 ? -54.494 49.938  11.612 1.00 54.28  ? 375  GLN B OE1   1 ? 
ATOM   7051 N NE2   . GLN B 1 396 ? -54.782 51.345  13.334 1.00 54.89  ? 375  GLN B NE2   1 ? 
ATOM   7052 N N     . ALA B 1 397 ? -54.835 54.016  7.804  1.00 45.78  ? 376  ALA B N     1 ? 
ATOM   7053 C CA    . ALA B 1 397 ? -54.526 54.182  6.389  1.00 48.30  ? 376  ALA B CA    1 ? 
ATOM   7054 C C     . ALA B 1 397 ? -53.101 54.702  6.197  1.00 44.25  ? 376  ALA B C     1 ? 
ATOM   7055 O O     . ALA B 1 397 ? -52.601 54.713  5.075  1.00 46.98  ? 376  ALA B O     1 ? 
ATOM   7056 C CB    . ALA B 1 397 ? -55.533 55.117  5.744  1.00 49.39  ? 376  ALA B CB    1 ? 
ATOM   7057 N N     . GLN B 1 398 ? -52.466 55.159  7.285  1.00 39.07  ? 377  GLN B N     1 ? 
ATOM   7058 C CA    . GLN B 1 398 ? -51.134 55.746  7.217  1.00 39.11  ? 377  GLN B CA    1 ? 
ATOM   7059 C C     . GLN B 1 398 ? -50.054 54.667  7.193  1.00 37.25  ? 377  GLN B C     1 ? 
ATOM   7060 O O     . GLN B 1 398 ? -50.199 53.608  7.816  1.00 34.49  ? 377  GLN B O     1 ? 
ATOM   7061 C CB    . GLN B 1 398 ? -50.824 56.631  8.418  1.00 40.88  ? 377  GLN B CB    1 ? 
ATOM   7062 C CG    . GLN B 1 398 ? -51.828 57.754  8.632  1.00 49.14  ? 377  GLN B CG    1 ? 
ATOM   7063 C CD    . GLN B 1 398 ? -52.073 58.566  7.378  1.00 51.26  ? 377  GLN B CD    1 ? 
ATOM   7064 O OE1   . GLN B 1 398 ? -51.134 58.932  6.664  1.00 47.82  ? 377  GLN B OE1   1 ? 
ATOM   7065 N NE2   . GLN B 1 398 ? -53.343 58.797  7.074  1.00 55.82  ? 377  GLN B NE2   1 ? 
ATOM   7066 N N     . SER B 1 399 ? -48.954 54.985  6.495  1.00 34.52  ? 378  SER B N     1 ? 
ATOM   7067 C CA    . SER B 1 399 ? -47.768 54.147  6.427  1.00 31.38  ? 378  SER B CA    1 ? 
ATOM   7068 C C     . SER B 1 399 ? -46.950 54.296  7.715  1.00 30.60  ? 378  SER B C     1 ? 
ATOM   7069 O O     . SER B 1 399 ? -47.077 55.283  8.442  1.00 32.78  ? 378  SER B O     1 ? 
ATOM   7070 C CB    . SER B 1 399 ? -46.935 54.520  5.240  1.00 31.51  ? 378  SER B CB    1 ? 
ATOM   7071 O OG    . SER B 1 399 ? -47.518 54.065  4.018  1.00 32.79  ? 378  SER B OG    1 ? 
ATOM   7072 N N     . GLY B 1 400 ? -46.061 53.330  7.936  1.00 30.02  ? 379  GLY B N     1 ? 
ATOM   7073 C CA    . GLY B 1 400 ? -45.172 53.337  9.083  1.00 31.75  ? 379  GLY B CA    1 ? 
ATOM   7074 C C     . GLY B 1 400 ? -44.455 51.997  9.248  1.00 28.75  ? 379  GLY B C     1 ? 
ATOM   7075 O O     . GLY B 1 400 ? -44.640 51.068  8.459  1.00 28.97  ? 379  GLY B O     1 ? 
ATOM   7076 N N     . TYR B 1 401 ? -43.634 51.916  10.298 1.00 28.82  ? 380  TYR B N     1 ? 
ATOM   7077 C CA    . TYR B 1 401 ? -42.867 50.712  10.598 1.00 28.69  ? 380  TYR B CA    1 ? 
ATOM   7078 C C     . TYR B 1 401 ? -42.732 50.570  12.117 1.00 26.60  ? 380  TYR B C     1 ? 
ATOM   7079 O O     . TYR B 1 401 ? -43.043 51.504  12.869 1.00 25.36  ? 380  TYR B O     1 ? 
ATOM   7080 C CB    . TYR B 1 401 ? -41.524 50.724  9.876  1.00 29.00  ? 380  TYR B CB    1 ? 
ATOM   7081 C CG    . TYR B 1 401 ? -40.531 51.728  10.432 1.00 28.14  ? 380  TYR B CG    1 ? 
ATOM   7082 C CD1   . TYR B 1 401 ? -40.591 53.085  10.110 1.00 31.91  ? 380  TYR B CD1   1 ? 
ATOM   7083 C CD2   . TYR B 1 401 ? -39.507 51.302  11.276 1.00 30.07  ? 380  TYR B CD2   1 ? 
ATOM   7084 C CE1   . TYR B 1 401 ? -39.675 53.988  10.642 1.00 33.56  ? 380  TYR B CE1   1 ? 
ATOM   7085 C CE2   . TYR B 1 401 ? -38.589 52.192  11.802 1.00 32.01  ? 380  TYR B CE2   1 ? 
ATOM   7086 C CZ    . TYR B 1 401 ? -38.667 53.538  11.478 1.00 31.88  ? 380  TYR B CZ    1 ? 
ATOM   7087 O OH    . TYR B 1 401 ? -37.764 54.394  12.042 1.00 29.94  ? 380  TYR B OH    1 ? 
ATOM   7088 N N     . SER B 1 402 ? -42.338 49.366  12.562 1.00 26.18  ? 381  SER B N     1 ? 
ATOM   7089 C CA    . SER B 1 402 ? -42.201 49.133  13.995 1.00 22.40  ? 381  SER B CA    1 ? 
ATOM   7090 C C     . SER B 1 402 ? -41.048 48.188  14.268 1.00 23.35  ? 381  SER B C     1 ? 
ATOM   7091 O O     . SER B 1 402 ? -40.655 47.361  13.429 1.00 23.23  ? 381  SER B O     1 ? 
ATOM   7092 C CB    . SER B 1 402 ? -43.490 48.654  14.606 1.00 25.44  ? 381  SER B CB    1 ? 
ATOM   7093 O OG    . SER B 1 402 ? -43.826 47.300  14.280 1.00 22.61  ? 381  SER B OG    1 ? 
ATOM   7094 N N     . VAL B 1 403 ? -40.455 48.376  15.450 1.00 24.71  ? 382  VAL B N     1 ? 
ATOM   7095 C CA    . VAL B 1 403 ? -39.325 47.575  15.880 1.00 24.48  ? 382  VAL B CA    1 ? 
ATOM   7096 C C     . VAL B 1 403 ? -39.656 47.078  17.285 1.00 25.25  ? 382  VAL B C     1 ? 
ATOM   7097 O O     . VAL B 1 403 ? -39.848 47.875  18.198 1.00 24.84  ? 382  VAL B O     1 ? 
ATOM   7098 C CB    . VAL B 1 403 ? -38.006 48.371  15.861 1.00 24.77  ? 382  VAL B CB    1 ? 
ATOM   7099 C CG1   . VAL B 1 403 ? -36.822 47.458  16.142 1.00 23.64  ? 382  VAL B CG1   1 ? 
ATOM   7100 C CG2   . VAL B 1 403 ? -37.806 49.149  14.547 1.00 27.04  ? 382  VAL B CG2   1 ? 
ATOM   7101 N N     . THR B 1 404 ? -39.779 45.761  17.418 1.00 25.59  ? 383  THR B N     1 ? 
ATOM   7102 C CA    . THR B 1 404 ? -40.126 45.147  18.693 1.00 25.89  ? 383  THR B CA    1 ? 
ATOM   7103 C C     . THR B 1 404 ? -38.834 44.714  19.370 1.00 23.24  ? 383  THR B C     1 ? 
ATOM   7104 O O     . THR B 1 404 ? -38.074 43.932  18.806 1.00 26.47  ? 383  THR B O     1 ? 
ATOM   7105 C CB    . THR B 1 404 ? -41.065 43.971  18.451 1.00 25.97  ? 383  THR B CB    1 ? 
ATOM   7106 O OG1   . THR B 1 404 ? -42.270 44.524  17.951 1.00 24.04  ? 383  THR B OG1   1 ? 
ATOM   7107 C CG2   . THR B 1 404 ? -41.362 43.174  19.706 1.00 29.36  ? 383  THR B CG2   1 ? 
ATOM   7108 N N     . VAL B 1 405 ? -38.621 45.218  20.582 1.00 22.81  ? 384  VAL B N     1 ? 
ATOM   7109 C CA    . VAL B 1 405 ? -37.416 44.953  21.333 1.00 23.89  ? 384  VAL B CA    1 ? 
ATOM   7110 C C     . VAL B 1 405 ? -37.699 43.861  22.356 1.00 24.09  ? 384  VAL B C     1 ? 
ATOM   7111 O O     . VAL B 1 405 ? -38.638 43.980  23.137 1.00 23.06  ? 384  VAL B O     1 ? 
ATOM   7112 C CB    . VAL B 1 405 ? -36.971 46.258  22.026 1.00 23.97  ? 384  VAL B CB    1 ? 
ATOM   7113 C CG1   . VAL B 1 405 ? -35.773 46.062  22.932 1.00 23.48  ? 384  VAL B CG1   1 ? 
ATOM   7114 C CG2   . VAL B 1 405 ? -36.713 47.353  21.015 1.00 27.69  ? 384  VAL B CG2   1 ? 
ATOM   7115 N N     . ILE B 1 406 ? -36.808 42.868  22.405 1.00 26.36  ? 385  ILE B N     1 ? 
ATOM   7116 C CA    . ILE B 1 406 ? -36.907 41.771  23.358 1.00 26.39  ? 385  ILE B CA    1 ? 
ATOM   7117 C C     . ILE B 1 406 ? -35.604 41.688  24.149 1.00 25.38  ? 385  ILE B C     1 ? 
ATOM   7118 O O     . ILE B 1 406 ? -34.514 41.567  23.566 1.00 24.86  ? 385  ILE B O     1 ? 
ATOM   7119 C CB    . ILE B 1 406 ? -37.201 40.438  22.666 1.00 24.33  ? 385  ILE B CB    1 ? 
ATOM   7120 C CG1   . ILE B 1 406 ? -38.464 40.484  21.873 1.00 24.54  ? 385  ILE B CG1   1 ? 
ATOM   7121 C CG2   . ILE B 1 406 ? -37.198 39.290  23.679 1.00 25.24  ? 385  ILE B CG2   1 ? 
ATOM   7122 C CD1   . ILE B 1 406 ? -38.623 39.351  20.875 1.00 24.58  ? 385  ILE B CD1   1 ? 
ATOM   7123 N N     . LEU B 1 407 ? -35.745 41.744  25.483 1.00 25.11  ? 386  LEU B N     1 ? 
ATOM   7124 C CA    . LEU B 1 407 ? -34.653 41.477  26.398 1.00 26.22  ? 386  LEU B CA    1 ? 
ATOM   7125 C C     . LEU B 1 407 ? -34.453 39.963  26.425 1.00 26.86  ? 386  LEU B C     1 ? 
ATOM   7126 O O     . LEU B 1 407 ? -35.302 39.227  26.921 1.00 23.68  ? 386  LEU B O     1 ? 
ATOM   7127 C CB    . LEU B 1 407 ? -34.957 42.022  27.799 1.00 27.17  ? 386  LEU B CB    1 ? 
ATOM   7128 C CG    . LEU B 1 407 ? -33.886 41.727  28.856 1.00 29.92  ? 386  LEU B CG    1 ? 
ATOM   7129 C CD1   . LEU B 1 407 ? -32.585 42.504  28.567 1.00 30.29  ? 386  LEU B CD1   1 ? 
ATOM   7130 C CD2   . LEU B 1 407 ? -34.392 41.999  30.271 1.00 32.39  ? 386  LEU B CD2   1 ? 
ATOM   7131 N N     . LEU B 1 408 ? -33.334 39.499  25.875 1.00 22.73  ? 387  LEU B N     1 ? 
ATOM   7132 C CA    . LEU B 1 408 ? -33.164 38.091  25.578 1.00 23.29  ? 387  LEU B CA    1 ? 
ATOM   7133 C C     . LEU B 1 408 ? -32.836 37.258  26.815 1.00 26.34  ? 387  LEU B C     1 ? 
ATOM   7134 O O     . LEU B 1 408 ? -33.164 36.068  26.836 1.00 25.41  ? 387  LEU B O     1 ? 
ATOM   7135 C CB    . LEU B 1 408 ? -32.101 37.928  24.498 1.00 23.38  ? 387  LEU B CB    1 ? 
ATOM   7136 C CG    . LEU B 1 408 ? -32.506 38.423  23.110 1.00 23.60  ? 387  LEU B CG    1 ? 
ATOM   7137 C CD1   . LEU B 1 408 ? -31.355 38.334  22.098 1.00 25.77  ? 387  LEU B CD1   1 ? 
ATOM   7138 C CD2   . LEU B 1 408 ? -33.701 37.628  22.639 1.00 22.39  ? 387  LEU B CD2   1 ? 
ATOM   7139 N N     . GLN B 1 409 ? -32.200 37.840  27.843 1.00 26.23  ? 388  GLN B N     1 ? 
ATOM   7140 C CA    . GLN B 1 409 ? -31.784 37.050  28.993 1.00 27.38  ? 388  GLN B CA    1 ? 
ATOM   7141 C C     . GLN B 1 409 ? -32.296 37.693  30.283 1.00 27.99  ? 388  GLN B C     1 ? 
ATOM   7142 O O     . GLN B 1 409 ? -31.522 38.161  31.125 1.00 24.42  ? 388  GLN B O     1 ? 
ATOM   7143 C CB    . GLN B 1 409 ? -30.270 36.839  28.971 1.00 30.01  ? 388  GLN B CB    1 ? 
ATOM   7144 C CG    . GLN B 1 409 ? -29.764 36.127  27.721 1.00 32.69  ? 388  GLN B CG    1 ? 
ATOM   7145 C CD    . GLN B 1 409 ? -30.039 34.638  27.721 1.00 38.06  ? 388  GLN B CD    1 ? 
ATOM   7146 O OE1   . GLN B 1 409 ? -29.336 33.874  28.393 1.00 43.00  ? 388  GLN B OE1   1 ? 
ATOM   7147 N NE2   . GLN B 1 409 ? -31.039 34.201  26.953 1.00 39.51  ? 388  GLN B NE2   1 ? 
ATOM   7148 N N     . PRO B 1 410 ? -33.629 37.696  30.510 1.00 23.81  ? 389  PRO B N     1 ? 
ATOM   7149 C CA    . PRO B 1 410 ? -34.174 38.233  31.755 1.00 22.94  ? 389  PRO B CA    1 ? 
ATOM   7150 C C     . PRO B 1 410 ? -33.659 37.404  32.932 1.00 23.37  ? 389  PRO B C     1 ? 
ATOM   7151 O O     . PRO B 1 410 ? -33.537 36.186  32.814 1.00 24.40  ? 389  PRO B O     1 ? 
ATOM   7152 C CB    . PRO B 1 410 ? -35.686 38.075  31.504 1.00 22.78  ? 389  PRO B CB    1 ? 
ATOM   7153 C CG    . PRO B 1 410 ? -35.787 36.816  30.652 1.00 22.65  ? 389  PRO B CG    1 ? 
ATOM   7154 C CD    . PRO B 1 410 ? -34.660 37.059  29.659 1.00 24.00  ? 389  PRO B CD    1 ? 
ATOM   7155 N N     . LYS B 1 411 ? -33.407 38.059  34.067 1.00 21.69  ? 390  LYS B N     1 ? 
ATOM   7156 C CA    . LYS B 1 411 ? -33.002 37.358  35.278 1.00 23.81  ? 390  LYS B CA    1 ? 
ATOM   7157 C C     . LYS B 1 411 ? -34.190 36.957  36.151 1.00 21.02  ? 390  LYS B C     1 ? 
ATOM   7158 O O     . LYS B 1 411 ? -34.029 36.124  37.020 1.00 18.91  ? 390  LYS B O     1 ? 
ATOM   7159 C CB    . LYS B 1 411 ? -32.119 38.217  36.191 1.00 29.26  ? 390  LYS B CB    1 ? 
ATOM   7160 C CG    . LYS B 1 411 ? -30.807 38.686  35.616 1.00 36.66  ? 390  LYS B CG    1 ? 
ATOM   7161 C CD    . LYS B 1 411 ? -29.659 37.690  35.642 1.00 48.73  ? 390  LYS B CD    1 ? 
ATOM   7162 C CE    . LYS B 1 411 ? -28.332 38.378  35.450 1.00 56.96  ? 390  LYS B CE    1 ? 
ATOM   7163 N NZ    . LYS B 1 411 ? -27.321 37.362  35.141 1.00 66.30  ? 390  LYS B NZ    1 ? 
ATOM   7164 N N     . SER B 1 412 ? -35.353 37.586  35.957 1.00 22.67  ? 391  SER B N     1 ? 
ATOM   7165 C CA    . SER B 1 412 ? -36.562 37.285  36.705 1.00 23.55  ? 391  SER B CA    1 ? 
ATOM   7166 C C     . SER B 1 412 ? -36.961 35.817  36.536 1.00 21.41  ? 391  SER B C     1 ? 
ATOM   7167 O O     . SER B 1 412 ? -36.836 35.237  35.459 1.00 21.90  ? 391  SER B O     1 ? 
ATOM   7168 C CB    . SER B 1 412 ? -37.684 38.175  36.250 1.00 25.36  ? 391  SER B CB    1 ? 
ATOM   7169 O OG    . SER B 1 412 ? -37.411 39.541  36.515 1.00 24.83  ? 391  SER B OG    1 ? 
ATOM   7170 N N     . ARG B 1 413 ? -37.346 35.191  37.646 1.00 22.98  ? 392  ARG B N     1 ? 
ATOM   7171 C CA    . ARG B 1 413 ? -37.799 33.805  37.660 1.00 22.29  ? 392  ARG B CA    1 ? 
ATOM   7172 C C     . ARG B 1 413 ? -39.091 33.727  38.453 1.00 24.46  ? 392  ARG B C     1 ? 
ATOM   7173 O O     . ARG B 1 413 ? -39.236 34.453  39.422 1.00 23.50  ? 392  ARG B O     1 ? 
ATOM   7174 C CB    . ARG B 1 413 ? -36.809 32.859  38.334 1.00 22.60  ? 392  ARG B CB    1 ? 
ATOM   7175 C CG    . ARG B 1 413 ? -35.529 32.676  37.550 1.00 23.04  ? 392  ARG B CG    1 ? 
ATOM   7176 C CD    . ARG B 1 413 ? -35.796 32.136  36.167 1.00 22.28  ? 392  ARG B CD    1 ? 
ATOM   7177 N NE    . ARG B 1 413 ? -34.561 31.851  35.432 1.00 22.35  ? 392  ARG B NE    1 ? 
ATOM   7178 C CZ    . ARG B 1 413 ? -33.978 32.686  34.572 1.00 23.30  ? 392  ARG B CZ    1 ? 
ATOM   7179 N NH1   . ARG B 1 413 ? -34.435 33.910  34.395 1.00 24.99  ? 392  ARG B NH1   1 ? 
ATOM   7180 N NH2   . ARG B 1 413 ? -32.928 32.305  33.881 1.00 24.82  ? 392  ARG B NH2   1 ? 
ATOM   7181 N N     . GLY B 1 414 ? -40.020 32.850  38.022 1.00 22.33  ? 393  GLY B N     1 ? 
ATOM   7182 C CA    . GLY B 1 414 ? -41.292 32.703  38.699 1.00 18.88  ? 393  GLY B CA    1 ? 
ATOM   7183 C C     . GLY B 1 414 ? -41.671 31.237  38.898 1.00 19.39  ? 393  GLY B C     1 ? 
ATOM   7184 O O     . GLY B 1 414 ? -40.815 30.337  38.973 1.00 19.61  ? 393  GLY B O     1 ? 
ATOM   7185 N N     . GLN B 1 415 ? -42.984 31.015  38.962 1.00 18.74  ? 394  GLN B N     1 ? 
ATOM   7186 C CA    . GLN B 1 415 ? -43.509 29.748  39.435 1.00 20.25  ? 394  GLN B CA    1 ? 
ATOM   7187 C C     . GLN B 1 415 ? -44.731 29.339  38.631 1.00 19.30  ? 394  GLN B C     1 ? 
ATOM   7188 O O     . GLN B 1 415 ? -45.512 30.183  38.202 1.00 18.16  ? 394  GLN B O     1 ? 
ATOM   7189 C CB    . GLN B 1 415 ? -43.990 29.852  40.875 1.00 21.15  ? 394  GLN B CB    1 ? 
ATOM   7190 C CG    . GLN B 1 415 ? -42.882 30.115  41.880 1.00 24.13  ? 394  GLN B CG    1 ? 
ATOM   7191 C CD    . GLN B 1 415 ? -43.401 30.155  43.296 1.00 23.06  ? 394  GLN B CD    1 ? 
ATOM   7192 O OE1   . GLN B 1 415 ? -43.044 29.328  44.140 1.00 23.23  ? 394  GLN B OE1   1 ? 
ATOM   7193 N NE2   . GLN B 1 415 ? -44.287 31.099  43.537 1.00 21.55  ? 394  GLN B NE2   1 ? 
ATOM   7194 N N     . LEU B 1 416 ? -44.873 28.021  38.484 1.00 19.28  ? 395  LEU B N     1 ? 
ATOM   7195 C CA    . LEU B 1 416 ? -46.089 27.357  38.043 1.00 18.29  ? 395  LEU B CA    1 ? 
ATOM   7196 C C     . LEU B 1 416 ? -46.612 26.535  39.217 1.00 18.05  ? 395  LEU B C     1 ? 
ATOM   7197 O O     . LEU B 1 416 ? -45.989 25.543  39.591 1.00 18.25  ? 395  LEU B O     1 ? 
ATOM   7198 C CB    . LEU B 1 416 ? -45.727 26.492  36.835 1.00 18.38  ? 395  LEU B CB    1 ? 
ATOM   7199 C CG    . LEU B 1 416 ? -46.844 25.769  36.068 1.00 18.73  ? 395  LEU B CG    1 ? 
ATOM   7200 C CD1   . LEU B 1 416 ? -47.627 24.815  36.944 1.00 18.12  ? 395  LEU B CD1   1 ? 
ATOM   7201 C CD2   . LEU B 1 416 ? -47.751 26.788  35.428 1.00 19.66  ? 395  LEU B CD2   1 ? 
ATOM   7202 N N     . LEU B 1 417 ? -47.710 26.990  39.825 1.00 16.42  ? 396  LEU B N     1 ? 
ATOM   7203 C CA    . LEU B 1 417 ? -48.273 26.394  41.024 1.00 18.50  ? 396  LEU B CA    1 ? 
ATOM   7204 C C     . LEU B 1 417 ? -49.591 25.695  40.699 1.00 19.71  ? 396  LEU B C     1 ? 
ATOM   7205 O O     . LEU B 1 417 ? -50.292 26.120  39.782 1.00 21.66  ? 396  LEU B O     1 ? 
ATOM   7206 C CB    . LEU B 1 417 ? -48.536 27.506  42.041 1.00 20.00  ? 396  LEU B CB    1 ? 
ATOM   7207 C CG    . LEU B 1 417 ? -47.314 28.293  42.504 1.00 22.53  ? 396  LEU B CG    1 ? 
ATOM   7208 C CD1   . LEU B 1 417 ? -47.680 29.241  43.665 1.00 25.36  ? 396  LEU B CD1   1 ? 
ATOM   7209 C CD2   . LEU B 1 417 ? -46.176 27.345  42.933 1.00 21.92  ? 396  LEU B CD2   1 ? 
ATOM   7210 N N     . LEU B 1 418 ? -49.967 24.686  41.514 1.00 19.49  ? 397  LEU B N     1 ? 
ATOM   7211 C CA    . LEU B 1 418 ? -51.312 24.119  41.455 1.00 21.45  ? 397  LEU B CA    1 ? 
ATOM   7212 C C     . LEU B 1 418 ? -52.331 25.108  42.024 1.00 22.01  ? 397  LEU B C     1 ? 
ATOM   7213 O O     . LEU B 1 418 ? -52.037 25.813  42.981 1.00 23.45  ? 397  LEU B O     1 ? 
ATOM   7214 C CB    . LEU B 1 418 ? -51.390 22.798  42.212 1.00 21.36  ? 397  LEU B CB    1 ? 
ATOM   7215 C CG    . LEU B 1 418 ? -50.580 21.631  41.653 1.00 23.43  ? 397  LEU B CG    1 ? 
ATOM   7216 C CD1   . LEU B 1 418 ? -50.798 20.463  42.621 1.00 25.30  ? 397  LEU B CD1   1 ? 
ATOM   7217 C CD2   . LEU B 1 418 ? -51.023 21.293  40.248 1.00 21.66  ? 397  LEU B CD2   1 ? 
ATOM   7218 N N     . ALA B 1 419 ? -53.539 25.156  41.448 1.00 19.63  ? 398  ALA B N     1 ? 
ATOM   7219 C CA    . ALA B 1 419 ? -54.654 25.859  42.061 1.00 22.05  ? 398  ALA B CA    1 ? 
ATOM   7220 C C     . ALA B 1 419 ? -55.382 24.947  43.047 1.00 24.88  ? 398  ALA B C     1 ? 
ATOM   7221 O O     . ALA B 1 419 ? -56.016 25.434  43.971 1.00 25.57  ? 398  ALA B O     1 ? 
ATOM   7222 C CB    . ALA B 1 419 ? -55.615 26.347  40.992 1.00 23.16  ? 398  ALA B CB    1 ? 
ATOM   7223 N N     . SER B 1 420 ? -55.333 23.635  42.803 1.00 23.31  ? 399  SER B N     1 ? 
ATOM   7224 C CA    . SER B 1 420 ? -56.165 22.645  43.480 1.00 24.73  ? 399  SER B CA    1 ? 
ATOM   7225 C C     . SER B 1 420 ? -55.678 21.254  43.077 1.00 24.70  ? 399  SER B C     1 ? 
ATOM   7226 O O     . SER B 1 420 ? -54.767 21.153  42.250 1.00 22.97  ? 399  SER B O     1 ? 
ATOM   7227 C CB    . SER B 1 420 ? -57.631 22.782  43.119 1.00 25.78  ? 399  SER B CB    1 ? 
ATOM   7228 O OG    . SER B 1 420 ? -57.831 22.283  41.796 1.00 25.64  ? 399  SER B OG    1 ? 
ATOM   7229 N N     . THR B 1 421 ? -56.324 20.198  43.617 1.00 22.19  ? 400  THR B N     1 ? 
ATOM   7230 C CA    . THR B 1 421 ? -56.038 18.840  43.185 1.00 24.14  ? 400  THR B CA    1 ? 
ATOM   7231 C C     . THR B 1 421 ? -56.983 18.412  42.072 1.00 23.64  ? 400  THR B C     1 ? 
ATOM   7232 O O     . THR B 1 421 ? -56.951 17.260  41.635 1.00 27.04  ? 400  THR B O     1 ? 
ATOM   7233 C CB    . THR B 1 421 ? -56.129 17.866  44.356 1.00 24.60  ? 400  THR B CB    1 ? 
ATOM   7234 O OG1   . THR B 1 421 ? -57.456 17.997  44.860 1.00 25.40  ? 400  THR B OG1   1 ? 
ATOM   7235 C CG2   . THR B 1 421 ? -55.119 18.174  45.438 1.00 27.23  ? 400  THR B CG2   1 ? 
ATOM   7236 N N     . ASN B 1 422 ? -57.840 19.314  41.617 1.00 23.60  ? 401  ASN B N     1 ? 
ATOM   7237 C CA    . ASN B 1 422 ? -58.770 18.987  40.547 1.00 24.43  ? 401  ASN B CA    1 ? 
ATOM   7238 C C     . ASN B 1 422 ? -58.002 18.980  39.227 1.00 23.52  ? 401  ASN B C     1 ? 
ATOM   7239 O O     . ASN B 1 422 ? -57.436 19.999  38.831 1.00 22.02  ? 401  ASN B O     1 ? 
ATOM   7240 C CB    . ASN B 1 422 ? -59.925 19.978  40.547 1.00 26.09  ? 401  ASN B CB    1 ? 
ATOM   7241 C CG    . ASN B 1 422 ? -60.905 19.811  39.404 1.00 29.61  ? 401  ASN B CG    1 ? 
ATOM   7242 O OD1   . ASN B 1 422 ? -60.621 19.204  38.361 1.00 26.88  ? 401  ASN B OD1   1 ? 
ATOM   7243 N ND2   . ASN B 1 422 ? -62.018 20.522  39.512 1.00 35.39  ? 401  ASN B ND2   1 ? 
ATOM   7244 N N     . PRO B 1 423 ? -57.937 17.837  38.522 1.00 23.90  ? 402  PRO B N     1 ? 
ATOM   7245 C CA    . PRO B 1 423 ? -57.083 17.734  37.336 1.00 24.14  ? 402  PRO B CA    1 ? 
ATOM   7246 C C     . PRO B 1 423 ? -57.448 18.663  36.193 1.00 22.35  ? 402  PRO B C     1 ? 
ATOM   7247 O O     . PRO B 1 423 ? -56.654 18.842  35.281 1.00 25.78  ? 402  PRO B O     1 ? 
ATOM   7248 C CB    . PRO B 1 423 ? -57.206 16.242  36.922 1.00 25.08  ? 402  PRO B CB    1 ? 
ATOM   7249 C CG    . PRO B 1 423 ? -58.427 15.723  37.614 1.00 25.08  ? 402  PRO B CG    1 ? 
ATOM   7250 C CD    . PRO B 1 423 ? -58.634 16.574  38.845 1.00 24.40  ? 402  PRO B CD    1 ? 
ATOM   7251 N N     . TYR B 1 424 ? -58.657 19.228  36.213 1.00 23.54  ? 403  TYR B N     1 ? 
ATOM   7252 C CA    . TYR B 1 424 ? -59.121 20.054  35.110 1.00 22.28  ? 403  TYR B CA    1 ? 
ATOM   7253 C C     . TYR B 1 424 ? -58.854 21.541  35.374 1.00 23.61  ? 403  TYR B C     1 ? 
ATOM   7254 O O     . TYR B 1 424 ? -58.993 22.344  34.451 1.00 27.18  ? 403  TYR B O     1 ? 
ATOM   7255 C CB    . TYR B 1 424 ? -60.622 19.792  34.879 1.00 24.23  ? 403  TYR B CB    1 ? 
ATOM   7256 C CG    . TYR B 1 424 ? -60.875 18.350  34.468 1.00 23.04  ? 403  TYR B CG    1 ? 
ATOM   7257 C CD1   . TYR B 1 424 ? -60.643 17.926  33.159 1.00 23.04  ? 403  TYR B CD1   1 ? 
ATOM   7258 C CD2   . TYR B 1 424 ? -61.218 17.385  35.416 1.00 21.83  ? 403  TYR B CD2   1 ? 
ATOM   7259 C CE1   . TYR B 1 424 ? -60.804 16.597  32.800 1.00 22.26  ? 403  TYR B CE1   1 ? 
ATOM   7260 C CE2   . TYR B 1 424 ? -61.345 16.052  35.066 1.00 21.87  ? 403  TYR B CE2   1 ? 
ATOM   7261 C CZ    . TYR B 1 424 ? -61.149 15.663  33.752 1.00 24.01  ? 403  TYR B CZ    1 ? 
ATOM   7262 O OH    . TYR B 1 424 ? -61.243 14.349  33.381 1.00 27.78  ? 403  TYR B OH    1 ? 
ATOM   7263 N N     . ASP B 1 425 ? -58.492 21.912  36.607 1.00 23.39  ? 404  ASP B N     1 ? 
ATOM   7264 C CA    . ASP B 1 425 ? -58.231 23.315  36.944 1.00 23.60  ? 404  ASP B CA    1 ? 
ATOM   7265 C C     . ASP B 1 425 ? -56.937 23.794  36.297 1.00 21.80  ? 404  ASP B C     1 ? 
ATOM   7266 O O     . ASP B 1 425 ? -55.923 23.091  36.311 1.00 18.59  ? 404  ASP B O     1 ? 
ATOM   7267 C CB    . ASP B 1 425 ? -58.162 23.571  38.442 1.00 24.28  ? 404  ASP B CB    1 ? 
ATOM   7268 C CG    . ASP B 1 425 ? -59.494 23.574  39.166 1.00 27.51  ? 404  ASP B CG    1 ? 
ATOM   7269 O OD1   . ASP B 1 425 ? -60.520 23.560  38.484 1.00 27.99  ? 404  ASP B OD1   1 ? 
ATOM   7270 O OD2   . ASP B 1 425 ? -59.485 23.567  40.409 1.00 30.99  ? 404  ASP B OD2   1 ? 
ATOM   7271 N N     . ALA B 1 426 ? -56.981 25.021  35.752 1.00 19.44  ? 405  ALA B N     1 ? 
ATOM   7272 C CA    . ALA B 1 426 ? -55.793 25.622  35.175 1.00 21.04  ? 405  ALA B CA    1 ? 
ATOM   7273 C C     . ALA B 1 426 ? -54.716 25.755  36.259 1.00 18.61  ? 405  ALA B C     1 ? 
ATOM   7274 O O     . ALA B 1 426 ? -55.034 26.026  37.427 1.00 20.38  ? 405  ALA B O     1 ? 
ATOM   7275 C CB    . ALA B 1 426 ? -56.119 26.976  34.569 1.00 22.31  ? 405  ALA B CB    1 ? 
ATOM   7276 N N     . PRO B 1 427 ? -53.421 25.628  35.906 1.00 17.83  ? 406  PRO B N     1 ? 
ATOM   7277 C CA    . PRO B 1 427 ? -52.317 25.919  36.823 1.00 17.64  ? 406  PRO B CA    1 ? 
ATOM   7278 C C     . PRO B 1 427 ? -52.217 27.437  36.955 1.00 17.67  ? 406  PRO B C     1 ? 
ATOM   7279 O O     . PRO B 1 427 ? -52.795 28.162  36.160 1.00 17.84  ? 406  PRO B O     1 ? 
ATOM   7280 C CB    . PRO B 1 427 ? -51.092 25.304  36.133 1.00 18.66  ? 406  PRO B CB    1 ? 
ATOM   7281 C CG    . PRO B 1 427 ? -51.397 25.464  34.645 1.00 18.18  ? 406  PRO B CG    1 ? 
ATOM   7282 C CD    . PRO B 1 427 ? -52.915 25.286  34.565 1.00 18.82  ? 406  PRO B CD    1 ? 
ATOM   7283 N N     . LEU B 1 428 ? -51.551 27.899  38.023 1.00 19.31  ? 407  LEU B N     1 ? 
ATOM   7284 C CA    . LEU B 1 428 ? -51.371 29.308  38.307 1.00 19.92  ? 407  LEU B CA    1 ? 
ATOM   7285 C C     . LEU B 1 428 ? -50.004 29.726  37.784 1.00 19.20  ? 407  LEU B C     1 ? 
ATOM   7286 O O     . LEU B 1 428 ? -48.978 29.278  38.277 1.00 18.90  ? 407  LEU B O     1 ? 
ATOM   7287 C CB    . LEU B 1 428 ? -51.544 29.610  39.796 1.00 21.85  ? 407  LEU B CB    1 ? 
ATOM   7288 C CG    . LEU B 1 428 ? -52.861 29.147  40.409 1.00 22.74  ? 407  LEU B CG    1 ? 
ATOM   7289 C CD1   . LEU B 1 428 ? -52.912 29.330  41.915 1.00 25.93  ? 407  LEU B CD1   1 ? 
ATOM   7290 C CD2   . LEU B 1 428 ? -54.019 29.915  39.757 1.00 25.30  ? 407  LEU B CD2   1 ? 
ATOM   7291 N N     . ILE B 1 429 ? -50.022 30.564  36.737 1.00 19.49  ? 408  ILE B N     1 ? 
ATOM   7292 C CA    . ILE B 1 429 ? -48.815 30.889  35.999 1.00 19.13  ? 408  ILE B CA    1 ? 
ATOM   7293 C C     . ILE B 1 429 ? -48.321 32.261  36.471 1.00 18.37  ? 408  ILE B C     1 ? 
ATOM   7294 O O     . ILE B 1 429 ? -49.016 33.272  36.298 1.00 19.48  ? 408  ILE B O     1 ? 
ATOM   7295 C CB    . ILE B 1 429 ? -49.134 30.887  34.500 1.00 18.15  ? 408  ILE B CB    1 ? 
ATOM   7296 C CG1   . ILE B 1 429 ? -49.707 29.531  34.031 1.00 17.83  ? 408  ILE B CG1   1 ? 
ATOM   7297 C CG2   . ILE B 1 429 ? -47.907 31.322  33.705 1.00 18.22  ? 408  ILE B CG2   1 ? 
ATOM   7298 C CD1   . ILE B 1 429 ? -50.332 29.582  32.651 1.00 17.59  ? 408  ILE B CD1   1 ? 
ATOM   7299 N N     . ASN B 1 430 ? -47.117 32.301  37.051 1.00 18.91  ? 409  ASN B N     1 ? 
ATOM   7300 C CA    . ASN B 1 430 ? -46.592 33.545  37.604 1.00 18.60  ? 409  ASN B CA    1 ? 
ATOM   7301 C C     . ASN B 1 430 ? -45.148 33.741  37.174 1.00 20.50  ? 409  ASN B C     1 ? 
ATOM   7302 O O     . ASN B 1 430 ? -44.236 33.323  37.882 1.00 19.99  ? 409  ASN B O     1 ? 
ATOM   7303 C CB    . ASN B 1 430 ? -46.729 33.607  39.127 1.00 20.17  ? 409  ASN B CB    1 ? 
ATOM   7304 C CG    . ASN B 1 430 ? -46.352 34.980  39.659 1.00 21.71  ? 409  ASN B CG    1 ? 
ATOM   7305 O OD1   . ASN B 1 430 ? -46.232 35.948  38.892 1.00 20.33  ? 409  ASN B OD1   1 ? 
ATOM   7306 N ND2   . ASN B 1 430 ? -46.193 35.105  40.962 1.00 22.18  ? 409  ASN B ND2   1 ? 
ATOM   7307 N N     . PRO B 1 431 ? -44.878 34.335  35.991 1.00 18.95  ? 410  PRO B N     1 ? 
ATOM   7308 C CA    . PRO B 1 431 ? -43.492 34.576  35.561 1.00 20.68  ? 410  PRO B CA    1 ? 
ATOM   7309 C C     . PRO B 1 431 ? -42.712 35.593  36.401 1.00 18.12  ? 410  PRO B C     1 ? 
ATOM   7310 O O     . PRO B 1 431 ? -41.501 35.622  36.337 1.00 17.16  ? 410  PRO B O     1 ? 
ATOM   7311 C CB    . PRO B 1 431 ? -43.668 35.045  34.095 1.00 19.06  ? 410  PRO B CB    1 ? 
ATOM   7312 C CG    . PRO B 1 431 ? -45.029 34.501  33.684 1.00 19.32  ? 410  PRO B CG    1 ? 
ATOM   7313 C CD    . PRO B 1 431 ? -45.840 34.702  34.953 1.00 21.01  ? 410  PRO B CD    1 ? 
ATOM   7314 N N     A ARG B 1 432 ? -43.415 36.398  37.207 0.50 19.58  ? 411  ARG B N     1 ? 
ATOM   7315 N N     B ARG B 1 432 ? -43.425 36.384  37.217 0.50 19.76  ? 411  ARG B N     1 ? 
ATOM   7316 C CA    A ARG B 1 432 ? -42.767 37.395  38.054 0.50 19.77  ? 411  ARG B CA    1 ? 
ATOM   7317 C CA    B ARG B 1 432 ? -42.818 37.423  38.043 0.50 20.12  ? 411  ARG B CA    1 ? 
ATOM   7318 C C     A ARG B 1 432 ? -41.960 38.345  37.162 0.50 20.22  ? 411  ARG B C     1 ? 
ATOM   7319 C C     B ARG B 1 432 ? -41.965 38.322  37.150 0.50 20.43  ? 411  ARG B C     1 ? 
ATOM   7320 O O     A ARG B 1 432 ? -40.820 38.698  37.458 0.50 20.56  ? 411  ARG B O     1 ? 
ATOM   7321 O O     B ARG B 1 432 ? -40.807 38.603  37.434 0.50 20.92  ? 411  ARG B O     1 ? 
ATOM   7322 C CB    A ARG B 1 432 ? -41.929 36.761  39.181 0.50 19.73  ? 411  ARG B CB    1 ? 
ATOM   7323 C CB    B ARG B 1 432 ? -42.066 36.851  39.254 0.50 20.34  ? 411  ARG B CB    1 ? 
ATOM   7324 C CG    A ARG B 1 432 ? -42.638 35.945  40.268 0.50 21.00  ? 411  ARG B CG    1 ? 
ATOM   7325 C CG    B ARG B 1 432 ? -42.967 36.220  40.317 0.50 21.49  ? 411  ARG B CG    1 ? 
ATOM   7326 C CD    A ARG B 1 432 ? -41.597 35.433  41.293 0.50 22.17  ? 411  ARG B CD    1 ? 
ATOM   7327 C CD    B ARG B 1 432 ? -42.221 35.945  41.620 0.50 22.98  ? 411  ARG B CD    1 ? 
ATOM   7328 N NE    A ARG B 1 432 ? -42.010 34.438  42.280 0.50 25.08  ? 411  ARG B NE    1 ? 
ATOM   7329 N NE    B ARG B 1 432 ? -42.908 35.050  42.550 0.50 26.65  ? 411  ARG B NE    1 ? 
ATOM   7330 C CZ    A ARG B 1 432 ? -41.290 33.424  42.763 0.50 25.10  ? 411  ARG B CZ    1 ? 
ATOM   7331 C CZ    B ARG B 1 432 ? -43.894 35.368  43.373 0.50 26.72  ? 411  ARG B CZ    1 ? 
ATOM   7332 N NH1   A ARG B 1 432 ? -40.162 33.014  42.210 0.50 24.76  ? 411  ARG B NH1   1 ? 
ATOM   7333 N NH1   B ARG B 1 432 ? -44.394 36.589  43.384 0.50 25.82  ? 411  ARG B NH1   1 ? 
ATOM   7334 N NH2   A ARG B 1 432 ? -41.762 32.761  43.793 0.50 28.45  ? 411  ARG B NH2   1 ? 
ATOM   7335 N NH2   B ARG B 1 432 ? -44.398 34.432  44.154 0.50 26.27  ? 411  ARG B NH2   1 ? 
ATOM   7336 N N     . TYR B 1 433 ? -42.579 38.804  36.070 1.00 20.02  ? 412  TYR B N     1 ? 
ATOM   7337 C CA    . TYR B 1 433 ? -41.895 39.675  35.145 1.00 19.45  ? 412  TYR B CA    1 ? 
ATOM   7338 C C     . TYR B 1 433 ? -41.419 40.932  35.896 1.00 19.87  ? 412  TYR B C     1 ? 
ATOM   7339 O O     . TYR B 1 433 ? -42.187 41.541  36.647 1.00 17.84  ? 412  TYR B O     1 ? 
ATOM   7340 C CB    . TYR B 1 433 ? -42.800 40.089  33.991 1.00 18.67  ? 412  TYR B CB    1 ? 
ATOM   7341 C CG    . TYR B 1 433 ? -43.356 38.994  33.088 1.00 17.66  ? 412  TYR B CG    1 ? 
ATOM   7342 C CD1   . TYR B 1 433 ? -42.542 38.300  32.191 1.00 15.88  ? 412  TYR B CD1   1 ? 
ATOM   7343 C CD2   . TYR B 1 433 ? -44.711 38.740  33.042 1.00 19.20  ? 412  TYR B CD2   1 ? 
ATOM   7344 C CE1   . TYR B 1 433 ? -43.062 37.330  31.355 1.00 17.07  ? 412  TYR B CE1   1 ? 
ATOM   7345 C CE2   . TYR B 1 433 ? -45.247 37.809  32.156 1.00 17.32  ? 412  TYR B CE2   1 ? 
ATOM   7346 C CZ    . TYR B 1 433 ? -44.415 37.087  31.322 1.00 16.52  ? 412  TYR B CZ    1 ? 
ATOM   7347 O OH    . TYR B 1 433 ? -44.956 36.177  30.427 1.00 17.48  ? 412  TYR B OH    1 ? 
ATOM   7348 N N     . PHE B 1 434 ? -40.178 41.339  35.596 1.00 20.66  ? 413  PHE B N     1 ? 
ATOM   7349 C CA    . PHE B 1 434 ? -39.528 42.531  36.145 1.00 22.99  ? 413  PHE B CA    1 ? 
ATOM   7350 C C     . PHE B 1 434 ? -39.399 42.463  37.671 1.00 26.01  ? 413  PHE B C     1 ? 
ATOM   7351 O O     . PHE B 1 434 ? -39.251 43.498  38.335 1.00 27.66  ? 413  PHE B O     1 ? 
ATOM   7352 C CB    . PHE B 1 434 ? -40.268 43.796  35.701 1.00 21.46  ? 413  PHE B CB    1 ? 
ATOM   7353 C CG    . PHE B 1 434 ? -40.145 44.110  34.220 1.00 23.38  ? 413  PHE B CG    1 ? 
ATOM   7354 C CD1   . PHE B 1 434 ? -38.895 44.193  33.610 1.00 25.64  ? 413  PHE B CD1   1 ? 
ATOM   7355 C CD2   . PHE B 1 434 ? -41.274 44.288  33.431 1.00 25.83  ? 413  PHE B CD2   1 ? 
ATOM   7356 C CE1   . PHE B 1 434 ? -38.775 44.484  32.266 1.00 26.40  ? 413  PHE B CE1   1 ? 
ATOM   7357 C CE2   . PHE B 1 434 ? -41.149 44.582  32.079 1.00 25.31  ? 413  PHE B CE2   1 ? 
ATOM   7358 C CZ    . PHE B 1 434 ? -39.904 44.668  31.496 1.00 26.25  ? 413  PHE B CZ    1 ? 
ATOM   7359 N N     . SER B 1 435 ? -39.352 41.249  38.226 1.00 24.48  ? 414  SER B N     1 ? 
ATOM   7360 C CA    . SER B 1 435 ? -39.147 41.100  39.650 1.00 24.54  ? 414  SER B CA    1 ? 
ATOM   7361 C C     . SER B 1 435 ? -37.664 41.295  39.981 1.00 23.95  ? 414  SER B C     1 ? 
ATOM   7362 O O     . SER B 1 435 ? -37.337 41.807  41.048 1.00 27.93  ? 414  SER B O     1 ? 
ATOM   7363 C CB    . SER B 1 435 ? -39.703 39.779  40.143 1.00 23.41  ? 414  SER B CB    1 ? 
ATOM   7364 O OG    . SER B 1 435 ? -39.043 38.692  39.514 1.00 21.98  ? 414  SER B OG    1 ? 
ATOM   7365 N N     . ASP B 1 436 ? -36.768 40.882  39.083 1.00 26.46  ? 415  ASP B N     1 ? 
ATOM   7366 C CA    . ASP B 1 436 ? -35.359 41.233  39.161 1.00 27.69  ? 415  ASP B CA    1 ? 
ATOM   7367 C C     . ASP B 1 436 ? -35.168 42.619  38.550 1.00 30.75  ? 415  ASP B C     1 ? 
ATOM   7368 O O     . ASP B 1 436 ? -35.469 42.813  37.365 1.00 28.28  ? 415  ASP B O     1 ? 
ATOM   7369 C CB    . ASP B 1 436 ? -34.449 40.169  38.545 1.00 29.23  ? 415  ASP B CB    1 ? 
ATOM   7370 C CG    . ASP B 1 436 ? -32.964 40.417  38.825 1.00 30.33  ? 415  ASP B CG    1 ? 
ATOM   7371 O OD1   . ASP B 1 436 ? -32.439 41.457  38.386 1.00 35.19  ? 415  ASP B OD1   1 ? 
ATOM   7372 O OD2   . ASP B 1 436 ? -32.333 39.601  39.479 1.00 28.16  ? 415  ASP B OD2   1 ? 
ATOM   7373 N N     . SER B 1 437 ? -34.605 43.556  39.352 1.00 29.87  ? 416  SER B N     1 ? 
ATOM   7374 C CA    . SER B 1 437 ? -34.527 44.970  38.990 1.00 29.19  ? 416  SER B CA    1 ? 
ATOM   7375 C C     . SER B 1 437 ? -33.601 45.230  37.800 1.00 25.79  ? 416  SER B C     1 ? 
ATOM   7376 O O     . SER B 1 437 ? -33.780 46.220  37.101 1.00 30.59  ? 416  SER B O     1 ? 
ATOM   7377 C CB    . SER B 1 437 ? -34.135 45.833  40.201 1.00 32.10  ? 416  SER B CB    1 ? 
ATOM   7378 O OG    . SER B 1 437 ? -32.862 45.411  40.663 1.00 30.91  ? 416  SER B OG    1 ? 
ATOM   7379 N N     . SER B 1 438 ? -32.671 44.332  37.497 1.00 24.59  ? 417  SER B N     1 ? 
ATOM   7380 C CA    . SER B 1 438 ? -31.823 44.485  36.324 1.00 28.78  ? 417  SER B CA    1 ? 
ATOM   7381 C C     . SER B 1 438 ? -32.595 44.354  35.010 1.00 30.69  ? 417  SER B C     1 ? 
ATOM   7382 O O     . SER B 1 438 ? -32.109 44.843  33.989 1.00 27.86  ? 417  SER B O     1 ? 
ATOM   7383 C CB    . SER B 1 438 ? -30.674 43.517  36.320 1.00 31.29  ? 417  SER B CB    1 ? 
ATOM   7384 O OG    . SER B 1 438 ? -31.085 42.211  35.960 1.00 37.42  ? 417  SER B OG    1 ? 
ATOM   7385 N N     . ASP B 1 439 ? -33.762 43.675  35.014 1.00 24.44  ? 418  ASP B N     1 ? 
ATOM   7386 C CA    . ASP B 1 439 ? -34.502 43.464  33.772 1.00 24.64  ? 418  ASP B CA    1 ? 
ATOM   7387 C C     . ASP B 1 439 ? -34.960 44.801  33.201 1.00 21.15  ? 418  ASP B C     1 ? 
ATOM   7388 O O     . ASP B 1 439 ? -34.713 45.096  32.033 1.00 23.46  ? 418  ASP B O     1 ? 
ATOM   7389 C CB    . ASP B 1 439 ? -35.628 42.443  33.928 1.00 22.45  ? 418  ASP B CB    1 ? 
ATOM   7390 C CG    . ASP B 1 439 ? -35.169 41.007  34.178 1.00 23.67  ? 418  ASP B CG    1 ? 
ATOM   7391 O OD1   . ASP B 1 439 ? -33.964 40.779  34.089 1.00 26.55  ? 418  ASP B OD1   1 ? 
ATOM   7392 O OD2   . ASP B 1 439 ? -36.035 40.109  34.435 1.00 20.05  ? 418  ASP B OD2   1 ? 
ATOM   7393 N N     . MET B 1 440 ? -35.662 45.599  33.999 1.00 21.58  ? 419  MET B N     1 ? 
ATOM   7394 C CA    . MET B 1 440 ? -36.135 46.898  33.533 1.00 23.56  ? 419  MET B CA    1 ? 
ATOM   7395 C C     . MET B 1 440 ? -34.972 47.867  33.250 1.00 25.13  ? 419  MET B C     1 ? 
ATOM   7396 O O     . MET B 1 440 ? -34.992 48.576  32.255 1.00 25.42  ? 419  MET B O     1 ? 
ATOM   7397 C CB    . MET B 1 440 ? -37.118 47.516  34.530 1.00 23.77  ? 419  MET B CB    1 ? 
ATOM   7398 C CG    . MET B 1 440 ? -37.700 48.845  34.077 1.00 24.19  ? 419  MET B CG    1 ? 
ATOM   7399 S SD    . MET B 1 440 ? -38.646 48.791  32.535 1.00 25.39  ? 419  MET B SD    1 ? 
ATOM   7400 C CE    . MET B 1 440 ? -40.089 47.936  33.174 1.00 24.38  ? 419  MET B CE    1 ? 
ATOM   7401 N N     . GLU B 1 441 ? -33.932 47.845  34.074 1.00 27.24  ? 420  GLU B N     1 ? 
ATOM   7402 C CA    . GLU B 1 441 ? -32.749 48.674  33.874 1.00 29.98  ? 420  GLU B CA    1 ? 
ATOM   7403 C C     . GLU B 1 441 ? -32.195 48.464  32.465 1.00 29.79  ? 420  GLU B C     1 ? 
ATOM   7404 O O     . GLU B 1 441 ? -32.042 49.427  31.711 1.00 27.23  ? 420  GLU B O     1 ? 
ATOM   7405 C CB    . GLU B 1 441 ? -31.748 48.372  34.977 1.00 30.13  ? 420  GLU B CB    1 ? 
ATOM   7406 C CG    . GLU B 1 441 ? -32.195 48.924  36.326 1.00 40.04  ? 420  GLU B CG    1 ? 
ATOM   7407 C CD    . GLU B 1 441 ? -31.307 48.611  37.530 1.00 45.50  ? 420  GLU B CD    1 ? 
ATOM   7408 O OE1   . GLU B 1 441 ? -31.623 49.177  38.592 1.00 53.55  ? 420  GLU B OE1   1 ? 
ATOM   7409 O OE2   . GLU B 1 441 ? -30.334 47.824  37.445 1.00 55.45  ? 420  GLU B OE2   1 ? 
ATOM   7410 N N     . ARG B 1 442 ? -31.977 47.193  32.089 1.00 30.88  ? 421  ARG B N     1 ? 
ATOM   7411 C CA    . ARG B 1 442 ? -31.455 46.850  30.775 1.00 29.52  ? 421  ARG B CA    1 ? 
ATOM   7412 C C     . ARG B 1 442 ? -32.468 47.169  29.669 1.00 30.66  ? 421  ARG B C     1 ? 
ATOM   7413 O O     . ARG B 1 442 ? -32.094 47.710  28.630 1.00 29.77  ? 421  ARG B O     1 ? 
ATOM   7414 C CB    . ARG B 1 442 ? -30.985 45.391  30.724 1.00 29.96  ? 421  ARG B CB    1 ? 
ATOM   7415 C CG    . ARG B 1 442 ? -29.743 45.093  31.552 1.00 32.05  ? 421  ARG B CG    1 ? 
ATOM   7416 C CD    . ARG B 1 442 ? -29.389 43.632  31.460 1.00 30.73  ? 421  ARG B CD    1 ? 
ATOM   7417 N NE    . ARG B 1 442 ? -30.294 42.773  32.230 1.00 33.89  ? 421  ARG B NE    1 ? 
ATOM   7418 C CZ    . ARG B 1 442 ? -30.554 41.485  31.977 1.00 32.61  ? 421  ARG B CZ    1 ? 
ATOM   7419 N NH1   . ARG B 1 442 ? -31.472 40.826  32.675 1.00 36.18  ? 421  ARG B NH1   1 ? 
ATOM   7420 N NH2   . ARG B 1 442 ? -29.938 40.872  30.990 1.00 33.04  ? 421  ARG B NH2   1 ? 
ATOM   7421 N N     . PHE B 1 443 ? -33.753 46.856  29.897 1.00 26.31  ? 422  PHE B N     1 ? 
ATOM   7422 C CA    . PHE B 1 443 ? -34.780 47.026  28.872 1.00 26.79  ? 422  PHE B CA    1 ? 
ATOM   7423 C C     . PHE B 1 443 ? -34.854 48.493  28.415 1.00 27.16  ? 422  PHE B C     1 ? 
ATOM   7424 O O     . PHE B 1 443 ? -35.006 48.769  27.227 1.00 22.98  ? 422  PHE B O     1 ? 
ATOM   7425 C CB    . PHE B 1 443 ? -36.136 46.522  29.395 1.00 25.64  ? 422  PHE B CB    1 ? 
ATOM   7426 C CG    . PHE B 1 443 ? -36.950 45.724  28.375 1.00 25.70  ? 422  PHE B CG    1 ? 
ATOM   7427 C CD1   . PHE B 1 443 ? -37.154 46.200  27.084 1.00 27.26  ? 422  PHE B CD1   1 ? 
ATOM   7428 C CD2   . PHE B 1 443 ? -37.473 44.482  28.697 1.00 25.73  ? 422  PHE B CD2   1 ? 
ATOM   7429 C CE1   . PHE B 1 443 ? -37.880 45.476  26.155 1.00 27.57  ? 422  PHE B CE1   1 ? 
ATOM   7430 C CE2   . PHE B 1 443 ? -38.247 43.773  27.780 1.00 24.09  ? 422  PHE B CE2   1 ? 
ATOM   7431 C CZ    . PHE B 1 443 ? -38.444 44.275  26.504 1.00 25.29  ? 422  PHE B CZ    1 ? 
ATOM   7432 N N     . ILE B 1 444 ? -34.792 49.444  29.365 1.00 28.23  ? 423  ILE B N     1 ? 
ATOM   7433 C CA    . ILE B 1 444 ? -34.851 50.860  29.022 1.00 27.92  ? 423  ILE B CA    1 ? 
ATOM   7434 C C     . ILE B 1 444 ? -33.682 51.208  28.099 1.00 27.25  ? 423  ILE B C     1 ? 
ATOM   7435 O O     . ILE B 1 444 ? -33.876 51.909  27.114 1.00 26.63  ? 423  ILE B O     1 ? 
ATOM   7436 C CB    . ILE B 1 444 ? -34.850 51.747  30.284 1.00 29.60  ? 423  ILE B CB    1 ? 
ATOM   7437 C CG1   . ILE B 1 444 ? -36.110 51.546  31.126 1.00 31.24  ? 423  ILE B CG1   1 ? 
ATOM   7438 C CG2   . ILE B 1 444 ? -34.640 53.215  29.920 1.00 28.62  ? 423  ILE B CG2   1 ? 
ATOM   7439 C CD1   . ILE B 1 444 ? -35.986 52.020  32.573 1.00 28.55  ? 423  ILE B CD1   1 ? 
ATOM   7440 N N     . LYS B 1 445 ? -32.488 50.695  28.413 1.00 28.76  ? 424  LYS B N     1 ? 
ATOM   7441 C CA    . LYS B 1 445 ? -31.294 50.916  27.609 1.00 31.76  ? 424  LYS B CA    1 ? 
ATOM   7442 C C     . LYS B 1 445 ? -31.486 50.351  26.199 1.00 32.17  ? 424  LYS B C     1 ? 
ATOM   7443 O O     . LYS B 1 445 ? -31.048 50.941  25.208 1.00 27.96  ? 424  LYS B O     1 ? 
ATOM   7444 C CB    . LYS B 1 445 ? -30.058 50.252  28.244 1.00 35.93  ? 424  LYS B CB    1 ? 
ATOM   7445 C CG    . LYS B 1 445 ? -29.096 51.064  29.106 1.00 44.22  ? 424  LYS B CG    1 ? 
ATOM   7446 C CD    . LYS B 1 445 ? -29.482 51.284  30.552 1.00 50.98  ? 424  LYS B CD    1 ? 
ATOM   7447 C CE    . LYS B 1 445 ? -28.354 51.831  31.370 1.00 57.20  ? 424  LYS B CE    1 ? 
ATOM   7448 N NZ    . LYS B 1 445 ? -27.451 50.775  31.828 1.00 63.40  ? 424  LYS B NZ    1 ? 
ATOM   7449 N N     . GLY B 1 446 ? -32.083 49.154  26.100 1.00 31.01  ? 425  GLY B N     1 ? 
ATOM   7450 C CA    . GLY B 1 446 ? -32.291 48.544  24.798 1.00 26.95  ? 425  GLY B CA    1 ? 
ATOM   7451 C C     . GLY B 1 446 ? -33.214 49.358  23.896 1.00 24.57  ? 425  GLY B C     1 ? 
ATOM   7452 O O     . GLY B 1 446 ? -33.039 49.380  22.671 1.00 28.24  ? 425  GLY B O     1 ? 
ATOM   7453 N N     . VAL B 1 447 ? -34.238 49.974  24.490 1.00 26.09  ? 426  VAL B N     1 ? 
ATOM   7454 C CA    . VAL B 1 447 ? -35.166 50.807  23.736 1.00 27.29  ? 426  VAL B CA    1 ? 
ATOM   7455 C C     . VAL B 1 447 ? -34.424 52.027  23.172 1.00 32.71  ? 426  VAL B C     1 ? 
ATOM   7456 O O     . VAL B 1 447 ? -34.581 52.378  22.001 1.00 27.94  ? 426  VAL B O     1 ? 
ATOM   7457 C CB    . VAL B 1 447 ? -36.347 51.204  24.629 1.00 28.11  ? 426  VAL B CB    1 ? 
ATOM   7458 C CG1   . VAL B 1 447 ? -37.204 52.300  24.019 1.00 27.62  ? 426  VAL B CG1   1 ? 
ATOM   7459 C CG2   . VAL B 1 447 ? -37.215 49.985  24.972 1.00 29.10  ? 426  VAL B CG2   1 ? 
ATOM   7460 N N     . ARG B 1 448 ? -33.587 52.655  24.006 1.00 34.39  ? 427  ARG B N     1 ? 
ATOM   7461 C CA    . ARG B 1 448 ? -32.838 53.838  23.587 1.00 33.37  ? 427  ARG B CA    1 ? 
ATOM   7462 C C     . ARG B 1 448 ? -31.873 53.475  22.476 1.00 30.49  ? 427  ARG B C     1 ? 
ATOM   7463 O O     . ARG B 1 448 ? -31.779 54.200  21.499 1.00 35.70  ? 427  ARG B O     1 ? 
ATOM   7464 C CB    . ARG B 1 448 ? -32.010 54.365  24.757 1.00 36.31  ? 427  ARG B CB    1 ? 
ATOM   7465 C CG    . ARG B 1 448 ? -32.834 55.141  25.755 1.00 41.51  ? 427  ARG B CG    1 ? 
ATOM   7466 C CD    . ARG B 1 448 ? -32.494 56.619  25.662 1.00 41.68  ? 427  ARG B CD    1 ? 
ATOM   7467 N NE    . ARG B 1 448 ? -33.074 57.171  26.890 1.00 44.57  ? 427  ARG B NE    1 ? 
ATOM   7468 C CZ    . ARG B 1 448 ? -34.205 57.840  26.900 1.00 52.48  ? 427  ARG B CZ    1 ? 
ATOM   7469 N NH1   . ARG B 1 448 ? -34.776 58.179  25.754 1.00 54.76  ? 427  ARG B NH1   1 ? 
ATOM   7470 N NH2   . ARG B 1 448 ? -34.756 58.183  28.044 1.00 52.74  ? 427  ARG B NH2   1 ? 
ATOM   7471 N N     . TYR B 1 449 ? -31.182 52.338  22.646 1.00 29.72  ? 428  TYR B N     1 ? 
ATOM   7472 C CA    . TYR B 1 449 ? -30.247 51.833  21.657 1.00 29.92  ? 428  TYR B CA    1 ? 
ATOM   7473 C C     . TYR B 1 449 ? -30.958 51.666  20.316 1.00 32.72  ? 428  TYR B C     1 ? 
ATOM   7474 O O     . TYR B 1 449 ? -30.479 52.146  19.286 1.00 33.01  ? 428  TYR B O     1 ? 
ATOM   7475 C CB    . TYR B 1 449 ? -29.593 50.531  22.134 1.00 32.41  ? 428  TYR B CB    1 ? 
ATOM   7476 C CG    . TYR B 1 449 ? -28.602 49.883  21.178 1.00 32.65  ? 428  TYR B CG    1 ? 
ATOM   7477 C CD1   . TYR B 1 449 ? -27.269 50.296  21.122 1.00 35.32  ? 428  TYR B CD1   1 ? 
ATOM   7478 C CD2   . TYR B 1 449 ? -29.001 48.889  20.294 1.00 32.66  ? 428  TYR B CD2   1 ? 
ATOM   7479 C CE1   . TYR B 1 449 ? -26.373 49.731  20.229 1.00 38.51  ? 428  TYR B CE1   1 ? 
ATOM   7480 C CE2   . TYR B 1 449 ? -28.106 48.298  19.419 1.00 34.59  ? 428  TYR B CE2   1 ? 
ATOM   7481 C CZ    . TYR B 1 449 ? -26.790 48.717  19.385 1.00 37.59  ? 428  TYR B CZ    1 ? 
ATOM   7482 O OH    . TYR B 1 449 ? -25.933 48.118  18.513 1.00 38.60  ? 428  TYR B OH    1 ? 
ATOM   7483 N N     . THR B 1 450 ? -32.098 50.965  20.342 1.00 29.99  ? 429  THR B N     1 ? 
ATOM   7484 C CA    . THR B 1 450 ? -32.859 50.663  19.144 1.00 29.04  ? 429  THR B CA    1 ? 
ATOM   7485 C C     . THR B 1 450 ? -33.318 51.953  18.467 1.00 28.40  ? 429  THR B C     1 ? 
ATOM   7486 O O     . THR B 1 450 ? -33.375 52.002  17.244 1.00 30.17  ? 429  THR B O     1 ? 
ATOM   7487 C CB    . THR B 1 450 ? -34.058 49.777  19.506 1.00 26.86  ? 429  THR B CB    1 ? 
ATOM   7488 O OG1   . THR B 1 450 ? -33.538 48.592  20.117 1.00 24.93  ? 429  THR B OG1   1 ? 
ATOM   7489 C CG2   . THR B 1 450 ? -34.880 49.447  18.276 1.00 27.34  ? 429  THR B CG2   1 ? 
ATOM   7490 N N     . GLN B 1 451 ? -33.706 52.971  19.240 1.00 29.24  ? 430  GLN B N     1 ? 
ATOM   7491 C CA    . GLN B 1 451 ? -34.211 54.207  18.649 1.00 35.85  ? 430  GLN B CA    1 ? 
ATOM   7492 C C     . GLN B 1 451 ? -33.186 54.939  17.760 1.00 35.17  ? 430  GLN B C     1 ? 
ATOM   7493 O O     . GLN B 1 451 ? -33.559 55.790  16.946 1.00 34.28  ? 430  GLN B O     1 ? 
ATOM   7494 C CB    . GLN B 1 451 ? -34.654 55.182  19.730 1.00 37.58  ? 430  GLN B CB    1 ? 
ATOM   7495 C CG    . GLN B 1 451 ? -35.948 54.774  20.414 1.00 36.48  ? 430  GLN B CG    1 ? 
ATOM   7496 C CD    . GLN B 1 451 ? -36.266 55.642  21.605 1.00 35.51  ? 430  GLN B CD    1 ? 
ATOM   7497 O OE1   . GLN B 1 451 ? -35.405 55.928  22.442 1.00 36.03  ? 430  GLN B OE1   1 ? 
ATOM   7498 N NE2   . GLN B 1 451 ? -37.516 56.068  21.686 1.00 38.00  ? 430  GLN B NE2   1 ? 
ATOM   7499 N N     . LYS B 1 452 ? -31.899 54.643  17.931 1.00 31.84  ? 431  LYS B N     1 ? 
ATOM   7500 C CA    . LYS B 1 452 ? -30.866 55.185  17.057 1.00 36.69  ? 431  LYS B CA    1 ? 
ATOM   7501 C C     . LYS B 1 452 ? -31.162 54.858  15.590 1.00 38.79  ? 431  LYS B C     1 ? 
ATOM   7502 O O     . LYS B 1 452 ? -30.731 55.558  14.682 1.00 35.77  ? 431  LYS B O     1 ? 
ATOM   7503 C CB    . LYS B 1 452 ? -29.473 54.681  17.448 1.00 40.98  ? 431  LYS B CB    1 ? 
ATOM   7504 C CG    . LYS B 1 452 ? -29.024 55.075  18.854 1.00 40.11  ? 431  LYS B CG    1 ? 
ATOM   7505 C CD    . LYS B 1 452 ? -27.551 54.835  19.144 1.00 39.00  ? 431  LYS B CD    1 ? 
ATOM   7506 C CE    . LYS B 1 452 ? -27.100 53.467  18.777 1.00 39.52  ? 431  LYS B CE    1 ? 
ATOM   7507 N NZ    . LYS B 1 452 ? -25.757 53.204  19.289 1.00 39.46  ? 431  LYS B NZ    1 ? 
ATOM   7508 N N     . ILE B 1 453 ? -31.943 53.813  15.334 1.00 34.55  ? 432  ILE B N     1 ? 
ATOM   7509 C CA    . ILE B 1 453 ? -32.143 53.378  13.967 1.00 33.75  ? 432  ILE B CA    1 ? 
ATOM   7510 C C     . ILE B 1 453 ? -32.953 54.425  13.203 1.00 33.30  ? 432  ILE B C     1 ? 
ATOM   7511 O O     . ILE B 1 453 ? -32.889 54.458  11.983 1.00 36.15  ? 432  ILE B O     1 ? 
ATOM   7512 C CB    . ILE B 1 453 ? -32.827 52.003  13.927 1.00 29.72  ? 432  ILE B CB    1 ? 
ATOM   7513 C CG1   . ILE B 1 453 ? -32.451 51.246  12.657 1.00 30.50  ? 432  ILE B CG1   1 ? 
ATOM   7514 C CG2   . ILE B 1 453 ? -34.333 52.169  14.076 1.00 32.24  ? 432  ILE B CG2   1 ? 
ATOM   7515 C CD1   . ILE B 1 453 ? -33.241 49.972  12.441 1.00 35.48  ? 432  ILE B CD1   1 ? 
ATOM   7516 N N     . THR B 1 454 ? -33.731 55.257  13.914 1.00 35.07  ? 433  THR B N     1 ? 
ATOM   7517 C CA    . THR B 1 454 ? -34.555 56.265  13.264 1.00 35.94  ? 433  THR B CA    1 ? 
ATOM   7518 C C     . THR B 1 454 ? -33.691 57.372  12.645 1.00 42.13  ? 433  THR B C     1 ? 
ATOM   7519 O O     . THR B 1 454 ? -34.196 58.178  11.868 1.00 40.60  ? 433  THR B O     1 ? 
ATOM   7520 C CB    . THR B 1 454 ? -35.551 56.881  14.246 1.00 36.00  ? 433  THR B CB    1 ? 
ATOM   7521 O OG1   . THR B 1 454 ? -34.759 57.554  15.212 1.00 35.16  ? 433  THR B OG1   1 ? 
ATOM   7522 C CG2   . THR B 1 454 ? -36.433 55.852  14.934 1.00 37.80  ? 433  THR B CG2   1 ? 
ATOM   7523 N N     . LYS B 1 455 ? -32.411 57.441  13.029 1.00 40.77  ? 434  LYS B N     1 ? 
ATOM   7524 C CA    . LYS B 1 455 ? -31.510 58.494  12.574 1.00 43.58  ? 434  LYS B CA    1 ? 
ATOM   7525 C C     . LYS B 1 455 ? -30.801 58.096  11.279 1.00 41.43  ? 434  LYS B C     1 ? 
ATOM   7526 O O     . LYS B 1 455 ? -30.048 58.893  10.735 1.00 39.70  ? 434  LYS B O     1 ? 
ATOM   7527 C CB    . LYS B 1 455 ? -30.519 58.815  13.704 1.00 46.42  ? 434  LYS B CB    1 ? 
ATOM   7528 C CG    . LYS B 1 455 ? -31.046 59.815  14.752 1.00 51.58  ? 434  LYS B CG    1 ? 
ATOM   7529 C CD    . LYS B 1 455 ? -30.578 59.628  16.197 1.00 64.21  ? 434  LYS B CD    1 ? 
ATOM   7530 C CE    . LYS B 1 455 ? -31.611 58.895  17.046 1.00 71.60  ? 434  LYS B CE    1 ? 
ATOM   7531 N NZ    . LYS B 1 455 ? -31.189 58.502  18.400 1.00 61.77  ? 434  LYS B NZ    1 ? 
ATOM   7532 N N     . THR B 1 456 ? -30.999 56.862  10.800 1.00 34.57  ? 435  THR B N     1 ? 
ATOM   7533 C CA    . THR B 1 456 ? -30.255 56.362  9.660  1.00 36.94  ? 435  THR B CA    1 ? 
ATOM   7534 C C     . THR B 1 456 ? -30.802 56.987  8.384  1.00 36.48  ? 435  THR B C     1 ? 
ATOM   7535 O O     . THR B 1 456 ? -31.942 57.428  8.335  1.00 36.88  ? 435  THR B O     1 ? 
ATOM   7536 C CB    . THR B 1 456 ? -30.321 54.835  9.579  1.00 40.43  ? 435  THR B CB    1 ? 
ATOM   7537 O OG1   . THR B 1 456 ? -31.703 54.523  9.417  1.00 37.43  ? 435  THR B OG1   1 ? 
ATOM   7538 C CG2   . THR B 1 456 ? -29.718 54.171  10.797 1.00 40.62  ? 435  THR B CG2   1 ? 
ATOM   7539 N N     . GLU B 1 457 ? -29.975 56.983  7.340  1.00 40.04  ? 436  GLU B N     1 ? 
ATOM   7540 C CA    . GLU B 1 457 ? -30.369 57.557  6.067  1.00 44.91  ? 436  GLU B CA    1 ? 
ATOM   7541 C C     . GLU B 1 457 ? -31.582 56.795  5.524  1.00 41.19  ? 436  GLU B C     1 ? 
ATOM   7542 O O     . GLU B 1 457 ? -32.512 57.409  5.002  1.00 37.36  ? 436  GLU B O     1 ? 
ATOM   7543 C CB    . GLU B 1 457 ? -29.155 57.572  5.139  1.00 52.98  ? 436  GLU B CB    1 ? 
ATOM   7544 C CG    . GLU B 1 457 ? -29.236 58.646  4.058  1.00 64.59  ? 436  GLU B CG    1 ? 
ATOM   7545 C CD    . GLU B 1 457 ? -27.934 58.802  3.275  1.00 76.96  ? 436  GLU B CD    1 ? 
ATOM   7546 O OE1   . GLU B 1 457 ? -27.950 58.587  2.040  1.00 81.34  ? 436  GLU B OE1   1 ? 
ATOM   7547 O OE2   . GLU B 1 457 ? -26.900 59.133  3.902  1.00 72.65  ? 436  GLU B OE2   1 ? 
ATOM   7548 N N     . SER B 1 458 ? -31.581 55.466  5.695  1.00 40.08  ? 437  SER B N     1 ? 
ATOM   7549 C CA    . SER B 1 458 ? -32.678 54.621  5.242  1.00 38.78  ? 437  SER B CA    1 ? 
ATOM   7550 C C     . SER B 1 458 ? -34.001 54.985  5.917  1.00 35.75  ? 437  SER B C     1 ? 
ATOM   7551 O O     . SER B 1 458 ? -35.007 55.071  5.220  1.00 38.69  ? 437  SER B O     1 ? 
ATOM   7552 C CB    . SER B 1 458 ? -32.374 53.157  5.433  1.00 38.94  ? 437  SER B CB    1 ? 
ATOM   7553 O OG    . SER B 1 458 ? -31.294 52.760  4.604  1.00 43.82  ? 437  SER B OG    1 ? 
ATOM   7554 N N     . LEU B 1 459 ? -34.019 55.171  7.249  1.00 37.38  ? 438  LEU B N     1 ? 
ATOM   7555 C CA    . LEU B 1 459 ? -35.276 55.170  8.001  1.00 37.10  ? 438  LEU B CA    1 ? 
ATOM   7556 C C     . LEU B 1 459 ? -35.700 56.561  8.478  1.00 35.45  ? 438  LEU B C     1 ? 
ATOM   7557 O O     . LEU B 1 459 ? -36.896 56.770  8.702  1.00 33.06  ? 438  LEU B O     1 ? 
ATOM   7558 C CB    . LEU B 1 459 ? -35.259 54.146  9.148  1.00 40.25  ? 438  LEU B CB    1 ? 
ATOM   7559 C CG    . LEU B 1 459 ? -35.209 52.670  8.724  1.00 39.10  ? 438  LEU B CG    1 ? 
ATOM   7560 C CD1   . LEU B 1 459 ? -35.053 51.714  9.889  1.00 40.83  ? 438  LEU B CD1   1 ? 
ATOM   7561 C CD2   . LEU B 1 459 ? -36.430 52.274  7.924  1.00 41.76  ? 438  LEU B CD2   1 ? 
ATOM   7562 N N     . GLU B 1 460 ? -34.777 57.539  8.584  1.00 41.54  ? 439  GLU B N     1 ? 
ATOM   7563 C CA    . GLU B 1 460 ? -35.155 58.910  8.933  1.00 45.42  ? 439  GLU B CA    1 ? 
ATOM   7564 C C     . GLU B 1 460 ? -36.294 59.432  8.032  1.00 40.85  ? 439  GLU B C     1 ? 
ATOM   7565 O O     . GLU B 1 460 ? -37.259 60.017  8.518  1.00 38.57  ? 439  GLU B O     1 ? 
ATOM   7566 C CB    . GLU B 1 460 ? -33.910 59.802  9.002  1.00 48.83  ? 439  GLU B CB    1 ? 
ATOM   7567 C CG    . GLU B 1 460 ? -34.237 61.254  9.340  1.00 59.56  ? 439  GLU B CG    1 ? 
ATOM   7568 C CD    . GLU B 1 460 ? -33.030 62.084  9.727  1.00 67.09  ? 439  GLU B CD    1 ? 
ATOM   7569 O OE1   . GLU B 1 460 ? -32.905 62.442  10.916 1.00 73.42  ? 439  GLU B OE1   1 ? 
ATOM   7570 O OE2   . GLU B 1 460 ? -32.214 62.368  8.832  1.00 77.18  ? 439  GLU B OE2   1 ? 
ATOM   7571 N N     . PRO B 1 461 ? -36.274 59.230  6.696  1.00 40.55  ? 440  PRO B N     1 ? 
ATOM   7572 C CA    . PRO B 1 461 ? -37.401 59.637  5.850  1.00 43.02  ? 440  PRO B CA    1 ? 
ATOM   7573 C C     . PRO B 1 461 ? -38.772 59.051  6.178  1.00 40.89  ? 440  PRO B C     1 ? 
ATOM   7574 O O     . PRO B 1 461 ? -39.788 59.575  5.721  1.00 41.98  ? 440  PRO B O     1 ? 
ATOM   7575 C CB    . PRO B 1 461 ? -36.947 59.188  4.431  1.00 42.04  ? 440  PRO B CB    1 ? 
ATOM   7576 C CG    . PRO B 1 461 ? -35.440 59.135  4.512  1.00 42.71  ? 440  PRO B CG    1 ? 
ATOM   7577 C CD    . PRO B 1 461 ? -35.155 58.662  5.919  1.00 42.98  ? 440  PRO B CD    1 ? 
ATOM   7578 N N     . TYR B 1 462 ? -38.803 57.943  6.933  1.00 40.67  ? 441  TYR B N     1 ? 
ATOM   7579 C CA    . TYR B 1 462 ? -40.060 57.285  7.276  1.00 35.28  ? 441  TYR B CA    1 ? 
ATOM   7580 C C     . TYR B 1 462 ? -40.446 57.485  8.742  1.00 36.25  ? 441  TYR B C     1 ? 
ATOM   7581 O O     . TYR B 1 462 ? -41.367 56.819  9.219  1.00 33.59  ? 441  TYR B O     1 ? 
ATOM   7582 C CB    . TYR B 1 462 ? -39.878 55.794  6.974  1.00 37.57  ? 441  TYR B CB    1 ? 
ATOM   7583 C CG    . TYR B 1 462 ? -39.647 55.485  5.506  1.00 33.56  ? 441  TYR B CG    1 ? 
ATOM   7584 C CD1   . TYR B 1 462 ? -40.713 55.360  4.633  1.00 36.36  ? 441  TYR B CD1   1 ? 
ATOM   7585 C CD2   . TYR B 1 462 ? -38.365 55.315  4.997  1.00 41.89  ? 441  TYR B CD2   1 ? 
ATOM   7586 C CE1   . TYR B 1 462 ? -40.518 55.091  3.291  1.00 40.58  ? 441  TYR B CE1   1 ? 
ATOM   7587 C CE2   . TYR B 1 462 ? -38.155 55.054  3.650  1.00 41.84  ? 441  TYR B CE2   1 ? 
ATOM   7588 C CZ    . TYR B 1 462 ? -39.236 54.936  2.797  1.00 44.65  ? 441  TYR B CZ    1 ? 
ATOM   7589 O OH    . TYR B 1 462 ? -39.034 54.674  1.470  1.00 54.60  ? 441  TYR B OH    1 ? 
ATOM   7590 N N     . THR B 1 463 ? -39.726 58.362  9.462  1.00 34.18  ? 442  THR B N     1 ? 
ATOM   7591 C CA    . THR B 1 463 ? -39.920 58.547  10.893 1.00 35.13  ? 442  THR B CA    1 ? 
ATOM   7592 C C     . THR B 1 463 ? -40.500 59.941  11.145 1.00 36.27  ? 442  THR B C     1 ? 
ATOM   7593 O O     . THR B 1 463 ? -39.764 60.888  11.402 1.00 45.10  ? 442  THR B O     1 ? 
ATOM   7594 C CB    . THR B 1 463 ? -38.598 58.333  11.633 1.00 32.78  ? 442  THR B CB    1 ? 
ATOM   7595 O OG1   . THR B 1 463 ? -38.051 57.068  11.264 1.00 30.86  ? 442  THR B OG1   1 ? 
ATOM   7596 C CG2   . THR B 1 463 ? -38.770 58.411  13.146 1.00 34.81  ? 442  THR B CG2   1 ? 
ATOM   7597 N N     . TYR B 1 464 ? -41.824 60.068  11.096 1.00 36.20  ? 443  TYR B N     1 ? 
ATOM   7598 C CA    . TYR B 1 464 ? -42.473 61.334  11.378 1.00 34.80  ? 443  TYR B CA    1 ? 
ATOM   7599 C C     . TYR B 1 464 ? -42.825 61.431  12.862 1.00 39.90  ? 443  TYR B C     1 ? 
ATOM   7600 O O     . TYR B 1 464 ? -42.431 62.379  13.538 1.00 39.16  ? 443  TYR B O     1 ? 
ATOM   7601 C CB    . TYR B 1 464 ? -43.699 61.431  10.471 1.00 39.48  ? 443  TYR B CB    1 ? 
ATOM   7602 C CG    . TYR B 1 464 ? -44.577 62.638  10.749 1.00 43.23  ? 443  TYR B CG    1 ? 
ATOM   7603 C CD1   . TYR B 1 464 ? -44.028 63.907  10.862 1.00 50.07  ? 443  TYR B CD1   1 ? 
ATOM   7604 C CD2   . TYR B 1 464 ? -45.942 62.499  10.945 1.00 48.69  ? 443  TYR B CD2   1 ? 
ATOM   7605 C CE1   . TYR B 1 464 ? -44.815 65.009  11.150 1.00 53.11  ? 443  TYR B CE1   1 ? 
ATOM   7606 C CE2   . TYR B 1 464 ? -46.743 63.594  11.222 1.00 51.02  ? 443  TYR B CE2   1 ? 
ATOM   7607 C CZ    . TYR B 1 464 ? -46.175 64.851  11.327 1.00 53.48  ? 443  TYR B CZ    1 ? 
ATOM   7608 O OH    . TYR B 1 464 ? -46.943 65.946  11.592 1.00 62.54  ? 443  TYR B OH    1 ? 
ATOM   7609 N N     . LEU B 1 465 ? -43.594 60.457  13.365 1.00 38.91  ? 444  LEU B N     1 ? 
ATOM   7610 C CA    . LEU B 1 465 ? -43.942 60.402  14.776 1.00 37.01  ? 444  LEU B CA    1 ? 
ATOM   7611 C C     . LEU B 1 465 ? -43.597 59.025  15.329 1.00 35.79  ? 444  LEU B C     1 ? 
ATOM   7612 O O     . LEU B 1 465 ? -43.641 58.033  14.592 1.00 31.69  ? 444  LEU B O     1 ? 
ATOM   7613 C CB    . LEU B 1 465 ? -45.426 60.718  14.918 1.00 42.32  ? 444  LEU B CB    1 ? 
ATOM   7614 C CG    . LEU B 1 465 ? -45.816 62.193  14.781 1.00 43.33  ? 444  LEU B CG    1 ? 
ATOM   7615 C CD1   . LEU B 1 465 ? -47.321 62.253  14.636 1.00 47.70  ? 444  LEU B CD1   1 ? 
ATOM   7616 C CD2   . LEU B 1 465 ? -45.322 63.022  15.961 1.00 43.99  ? 444  LEU B CD2   1 ? 
ATOM   7617 N N     . ALA B 1 466 ? -43.235 59.005  16.624 1.00 33.14  ? 445  ALA B N     1 ? 
ATOM   7618 C CA    . ALA B 1 466 ? -42.745 57.811  17.293 1.00 32.06  ? 445  ALA B CA    1 ? 
ATOM   7619 C C     . ALA B 1 466 ? -43.495 57.576  18.598 1.00 39.32  ? 445  ALA B C     1 ? 
ATOM   7620 O O     . ALA B 1 466 ? -43.891 58.528  19.288 1.00 35.76  ? 445  ALA B O     1 ? 
ATOM   7621 C CB    . ALA B 1 466 ? -41.281 57.956  17.571 1.00 33.18  ? 445  ALA B CB    1 ? 
ATOM   7622 N N     . HIS B 1 467 ? -43.643 56.284  18.938 1.00 34.03  ? 446  HIS B N     1 ? 
ATOM   7623 C CA    . HIS B 1 467 ? -44.103 55.854  20.248 1.00 31.10  ? 446  HIS B CA    1 ? 
ATOM   7624 C C     . HIS B 1 467 ? -43.141 54.783  20.738 1.00 32.42  ? 446  HIS B C     1 ? 
ATOM   7625 O O     . HIS B 1 467 ? -43.011 53.746  20.085 1.00 31.17  ? 446  HIS B O     1 ? 
ATOM   7626 C CB    . HIS B 1 467 ? -45.516 55.268  20.154 1.00 35.48  ? 446  HIS B CB    1 ? 
ATOM   7627 C CG    . HIS B 1 467 ? -45.991 54.609  21.404 1.00 37.09  ? 446  HIS B CG    1 ? 
ATOM   7628 N ND1   . HIS B 1 467 ? -46.607 55.304  22.420 1.00 36.51  ? 446  HIS B ND1   1 ? 
ATOM   7629 C CD2   . HIS B 1 467 ? -45.946 53.325  21.801 1.00 39.40  ? 446  HIS B CD2   1 ? 
ATOM   7630 C CE1   . HIS B 1 467 ? -46.942 54.454  23.383 1.00 41.46  ? 446  HIS B CE1   1 ? 
ATOM   7631 N NE2   . HIS B 1 467 ? -46.543 53.247  23.032 1.00 37.77  ? 446  HIS B NE2   1 ? 
ATOM   7632 N N     . PRO B 1 468 ? -42.424 54.968  21.874 1.00 32.72  ? 447  PRO B N     1 ? 
ATOM   7633 C CA    . PRO B 1 468 ? -42.410 56.231  22.629 1.00 32.54  ? 447  PRO B CA    1 ? 
ATOM   7634 C C     . PRO B 1 468 ? -41.796 57.368  21.816 1.00 33.95  ? 447  PRO B C     1 ? 
ATOM   7635 O O     . PRO B 1 468 ? -41.064 57.112  20.854 1.00 32.54  ? 447  PRO B O     1 ? 
ATOM   7636 C CB    . PRO B 1 468 ? -41.507 55.924  23.842 1.00 31.49  ? 447  PRO B CB    1 ? 
ATOM   7637 C CG    . PRO B 1 468 ? -41.474 54.410  23.920 1.00 33.59  ? 447  PRO B CG    1 ? 
ATOM   7638 C CD    . PRO B 1 468 ? -41.557 53.951  22.477 1.00 32.76  ? 447  PRO B CD    1 ? 
ATOM   7639 N N     . ALA B 1 469 ? -42.037 58.613  22.242 1.00 38.78  ? 448  ALA B N     1 ? 
ATOM   7640 C CA    . ALA B 1 469 ? -41.379 59.755  21.617 1.00 41.09  ? 448  ALA B CA    1 ? 
ATOM   7641 C C     . ALA B 1 469 ? -39.866 59.602  21.766 1.00 43.65  ? 448  ALA B C     1 ? 
ATOM   7642 O O     . ALA B 1 469 ? -39.372 59.023  22.741 1.00 40.53  ? 448  ALA B O     1 ? 
ATOM   7643 C CB    . ALA B 1 469 ? -41.880 61.056  22.227 1.00 42.62  ? 448  ALA B CB    1 ? 
ATOM   7644 N N     . LEU B 1 470 ? -39.124 60.131  20.787 1.00 44.61  ? 449  LEU B N     1 ? 
ATOM   7645 C CA    . LEU B 1 470 ? -37.679 59.980  20.788 1.00 48.34  ? 449  LEU B CA    1 ? 
ATOM   7646 C C     . LEU B 1 470 ? -37.044 60.775  21.932 1.00 43.27  ? 449  LEU B C     1 ? 
ATOM   7647 O O     . LEU B 1 470 ? -35.929 60.459  22.333 1.00 45.97  ? 449  LEU B O     1 ? 
ATOM   7648 C CB    . LEU B 1 470 ? -37.145 60.388  19.416 1.00 51.11  ? 449  LEU B CB    1 ? 
ATOM   7649 C CG    . LEU B 1 470 ? -37.675 59.572  18.232 1.00 52.82  ? 449  LEU B CG    1 ? 
ATOM   7650 C CD1   . LEU B 1 470 ? -37.172 60.167  16.918 1.00 53.05  ? 449  LEU B CD1   1 ? 
ATOM   7651 C CD2   . LEU B 1 470 ? -37.281 58.100  18.382 1.00 51.87  ? 449  LEU B CD2   1 ? 
ATOM   7652 N N     . ASP B 1 471 ? -37.769 61.769  22.474 1.00 46.87  ? 450  ASP B N     1 ? 
ATOM   7653 C CA    . ASP B 1 471 ? -37.280 62.600  23.572 1.00 49.80  ? 450  ASP B CA    1 ? 
ATOM   7654 C C     . ASP B 1 471 ? -37.817 62.139  24.931 1.00 47.80  ? 450  ASP B C     1 ? 
ATOM   7655 O O     . ASP B 1 471 ? -37.615 62.820  25.931 1.00 45.36  ? 450  ASP B O     1 ? 
ATOM   7656 C CB    . ASP B 1 471 ? -37.606 64.073  23.335 1.00 51.42  ? 450  ASP B CB    1 ? 
ATOM   7657 C CG    . ASP B 1 471 ? -39.083 64.441  23.304 1.00 55.65  ? 450  ASP B CG    1 ? 
ATOM   7658 O OD1   . ASP B 1 471 ? -39.922 63.531  23.453 1.00 63.62  ? 450  ASP B OD1   1 ? 
ATOM   7659 O OD2   . ASP B 1 471 ? -39.390 65.642  23.160 1.00 62.48  ? 450  ASP B OD2   1 ? 
ATOM   7660 N N     . ALA B 1 472 ? -38.509 60.989  24.986 1.00 44.96  ? 451  ALA B N     1 ? 
ATOM   7661 C CA    . ALA B 1 472 ? -39.106 60.530  26.231 1.00 36.98  ? 451  ALA B CA    1 ? 
ATOM   7662 C C     . ALA B 1 472 ? -38.037 60.283  27.289 1.00 32.36  ? 451  ALA B C     1 ? 
ATOM   7663 O O     . ALA B 1 472 ? -36.954 59.801  26.972 1.00 35.86  ? 451  ALA B O     1 ? 
ATOM   7664 C CB    . ALA B 1 472 ? -39.895 59.265  25.975 1.00 37.47  ? 451  ALA B CB    1 ? 
ATOM   7665 N N     . THR B 1 473 ? -38.387 60.542  28.553 1.00 34.11  ? 452  THR B N     1 ? 
ATOM   7666 C CA    . THR B 1 473 ? -37.500 60.276  29.677 1.00 33.49  ? 452  THR B CA    1 ? 
ATOM   7667 C C     . THR B 1 473 ? -37.423 58.759  29.913 1.00 35.85  ? 452  THR B C     1 ? 
ATOM   7668 O O     . THR B 1 473 ? -38.278 58.012  29.435 1.00 33.69  ? 452  THR B O     1 ? 
ATOM   7669 C CB    . THR B 1 473 ? -38.009 61.020  30.913 1.00 37.69  ? 452  THR B CB    1 ? 
ATOM   7670 O OG1   . THR B 1 473 ? -39.268 60.471  31.285 1.00 36.17  ? 452  THR B OG1   1 ? 
ATOM   7671 C CG2   . THR B 1 473 ? -38.249 62.509  30.684 1.00 39.30  ? 452  THR B CG2   1 ? 
ATOM   7672 N N     . ASP B 1 474 ? -36.408 58.323  30.678 1.00 32.40  ? 453  ASP B N     1 ? 
ATOM   7673 C CA    . ASP B 1 474 ? -36.304 56.946  31.145 1.00 32.37  ? 453  ASP B CA    1 ? 
ATOM   7674 C C     . ASP B 1 474 ? -37.601 56.501  31.828 1.00 34.41  ? 453  ASP B C     1 ? 
ATOM   7675 O O     . ASP B 1 474 ? -38.054 55.367  31.630 1.00 26.25  ? 453  ASP B O     1 ? 
ATOM   7676 C CB    . ASP B 1 474 ? -35.107 56.732  32.052 1.00 36.25  ? 453  ASP B CB    1 ? 
ATOM   7677 C CG    . ASP B 1 474 ? -33.748 56.638  31.365 1.00 37.92  ? 453  ASP B CG    1 ? 
ATOM   7678 O OD1   . ASP B 1 474 ? -33.688 56.781  30.126 1.00 41.19  ? 453  ASP B OD1   1 ? 
ATOM   7679 O OD2   . ASP B 1 474 ? -32.773 56.360  32.066 1.00 37.58  ? 453  ASP B OD2   1 ? 
ATOM   7680 N N     . GLU B 1 475 ? -38.198 57.404  32.617 1.00 31.48  ? 454  GLU B N     1 ? 
ATOM   7681 C CA    . GLU B 1 475 ? -39.350 57.072  33.435 1.00 32.00  ? 454  GLU B CA    1 ? 
ATOM   7682 C C     . GLU B 1 475 ? -40.581 56.876  32.555 1.00 32.22  ? 454  GLU B C     1 ? 
ATOM   7683 O O     . GLU B 1 475 ? -41.435 56.047  32.862 1.00 30.80  ? 454  GLU B O     1 ? 
ATOM   7684 C CB    . GLU B 1 475 ? -39.612 58.176  34.458 1.00 30.30  ? 454  GLU B CB    1 ? 
ATOM   7685 C CG    . GLU B 1 475 ? -38.629 58.177  35.613 1.00 32.45  ? 454  GLU B CG    1 ? 
ATOM   7686 C CD    . GLU B 1 475 ? -37.311 58.848  35.317 1.00 33.75  ? 454  GLU B CD    1 ? 
ATOM   7687 O OE1   . GLU B 1 475 ? -36.496 58.764  36.239 1.00 40.72  ? 454  GLU B OE1   1 ? 
ATOM   7688 O OE2   . GLU B 1 475 ? -37.087 59.394  34.218 1.00 31.58  ? 454  GLU B OE2   1 ? 
ATOM   7689 N N     . ILE B 1 476 ? -40.714 57.692  31.505 1.00 32.55  ? 455  ILE B N     1 ? 
ATOM   7690 C CA    . ILE B 1 476 ? -41.799 57.526  30.552 1.00 34.52  ? 455  ILE B CA    1 ? 
ATOM   7691 C C     . ILE B 1 476 ? -41.627 56.211  29.793 1.00 30.16  ? 455  ILE B C     1 ? 
ATOM   7692 O O     . ILE B 1 476 ? -42.610 55.488  29.629 1.00 28.70  ? 455  ILE B O     1 ? 
ATOM   7693 C CB    . ILE B 1 476 ? -41.920 58.732  29.606 1.00 42.73  ? 455  ILE B CB    1 ? 
ATOM   7694 C CG1   . ILE B 1 476 ? -42.366 59.993  30.368 1.00 49.65  ? 455  ILE B CG1   1 ? 
ATOM   7695 C CG2   . ILE B 1 476 ? -42.862 58.421  28.445 1.00 42.81  ? 455  ILE B CG2   1 ? 
ATOM   7696 C CD1   . ILE B 1 476 ? -42.090 61.294  29.626 1.00 58.44  ? 455  ILE B CD1   1 ? 
ATOM   7697 N N     . ILE B 1 477 ? -40.398 55.885  29.375 1.00 27.09  ? 456  ILE B N     1 ? 
ATOM   7698 C CA    . ILE B 1 477 ? -40.179 54.608  28.700 1.00 30.08  ? 456  ILE B CA    1 ? 
ATOM   7699 C C     . ILE B 1 477 ? -40.529 53.449  29.648 1.00 29.55  ? 456  ILE B C     1 ? 
ATOM   7700 O O     . ILE B 1 477 ? -41.282 52.548  29.275 1.00 23.62  ? 456  ILE B O     1 ? 
ATOM   7701 C CB    . ILE B 1 477 ? -38.756 54.515  28.131 1.00 30.40  ? 456  ILE B CB    1 ? 
ATOM   7702 C CG1   . ILE B 1 477 ? -38.553 55.544  27.006 1.00 31.72  ? 456  ILE B CG1   1 ? 
ATOM   7703 C CG2   . ILE B 1 477 ? -38.452 53.087  27.662 1.00 29.41  ? 456  ILE B CG2   1 ? 
ATOM   7704 C CD1   . ILE B 1 477 ? -37.105 55.684  26.548 1.00 31.25  ? 456  ILE B CD1   1 ? 
ATOM   7705 N N     . GLU B 1 478 ? -40.012 53.495  30.882 1.00 25.61  ? 457  GLU B N     1 ? 
ATOM   7706 C CA    . GLU B 1 478 ? -40.339 52.500  31.901 1.00 25.49  ? 457  GLU B CA    1 ? 
ATOM   7707 C C     . GLU B 1 478 ? -41.850 52.264  32.028 1.00 25.91  ? 457  GLU B C     1 ? 
ATOM   7708 O O     . GLU B 1 478 ? -42.326 51.130  31.991 1.00 23.43  ? 457  GLU B O     1 ? 
ATOM   7709 C CB    . GLU B 1 478 ? -39.725 52.918  33.235 1.00 23.11  ? 457  GLU B CB    1 ? 
ATOM   7710 C CG    . GLU B 1 478 ? -39.943 51.902  34.339 1.00 25.82  ? 457  GLU B CG    1 ? 
ATOM   7711 C CD    . GLU B 1 478 ? -39.149 52.232  35.599 1.00 29.48  ? 457  GLU B CD    1 ? 
ATOM   7712 O OE1   . GLU B 1 478 ? -39.083 51.319  36.420 1.00 26.61  ? 457  GLU B OE1   1 ? 
ATOM   7713 O OE2   . GLU B 1 478 ? -38.630 53.361  35.774 1.00 27.91  ? 457  GLU B OE2   1 ? 
ATOM   7714 N N     . SER B 1 479 ? -42.608 53.343  32.180 1.00 24.62  ? 458  SER B N     1 ? 
ATOM   7715 C CA    . SER B 1 479 ? -44.045 53.257  32.345 1.00 26.16  ? 458  SER B CA    1 ? 
ATOM   7716 C C     . SER B 1 479 ? -44.748 52.635  31.135 1.00 25.61  ? 458  SER B C     1 ? 
ATOM   7717 O O     . SER B 1 479 ? -45.699 51.865  31.316 1.00 25.13  ? 458  SER B O     1 ? 
ATOM   7718 C CB    . SER B 1 479 ? -44.622 54.593  32.702 1.00 26.06  ? 458  SER B CB    1 ? 
ATOM   7719 O OG    . SER B 1 479 ? -44.254 54.831  34.059 1.00 29.93  ? 458  SER B OG    1 ? 
ATOM   7720 N N     . LEU B 1 480 ? -44.299 52.982  29.924 1.00 23.26  ? 459  LEU B N     1 ? 
ATOM   7721 C CA    . LEU B 1 480 ? -44.849 52.425  28.702 1.00 23.88  ? 459  LEU B CA    1 ? 
ATOM   7722 C C     . LEU B 1 480 ? -44.539 50.932  28.618 1.00 23.17  ? 459  LEU B C     1 ? 
ATOM   7723 O O     . LEU B 1 480 ? -45.404 50.125  28.220 1.00 25.73  ? 459  LEU B O     1 ? 
ATOM   7724 C CB    . LEU B 1 480 ? -44.324 53.195  27.494 1.00 26.57  ? 459  LEU B CB    1 ? 
ATOM   7725 C CG    . LEU B 1 480 ? -44.891 54.611  27.348 1.00 28.58  ? 459  LEU B CG    1 ? 
ATOM   7726 C CD1   . LEU B 1 480 ? -44.300 55.289  26.133 1.00 30.85  ? 459  LEU B CD1   1 ? 
ATOM   7727 C CD2   . LEU B 1 480 ? -46.391 54.593  27.287 1.00 28.88  ? 459  LEU B CD2   1 ? 
ATOM   7728 N N     . ILE B 1 481 ? -43.325 50.558  29.032 1.00 22.03  ? 460  ILE B N     1 ? 
ATOM   7729 C CA    . ILE B 1 481 ? -42.969 49.148  29.066 1.00 25.01  ? 460  ILE B CA    1 ? 
ATOM   7730 C C     . ILE B 1 481 ? -43.918 48.418  30.030 1.00 25.08  ? 460  ILE B C     1 ? 
ATOM   7731 O O     . ILE B 1 481 ? -44.506 47.392  29.681 1.00 21.90  ? 460  ILE B O     1 ? 
ATOM   7732 C CB    . ILE B 1 481 ? -41.474 48.953  29.394 1.00 24.43  ? 460  ILE B CB    1 ? 
ATOM   7733 C CG1   . ILE B 1 481 ? -40.595 49.480  28.267 1.00 25.08  ? 460  ILE B CG1   1 ? 
ATOM   7734 C CG2   . ILE B 1 481 ? -41.146 47.494  29.677 1.00 24.59  ? 460  ILE B CG2   1 ? 
ATOM   7735 C CD1   . ILE B 1 481 ? -39.116 49.433  28.545 1.00 25.26  ? 460  ILE B CD1   1 ? 
ATOM   7736 N N     . ARG B 1 482 ? -44.092 48.941  31.243 1.00 22.10  ? 461  ARG B N     1 ? 
ATOM   7737 C CA    . ARG B 1 482 ? -44.908 48.247  32.228 1.00 24.13  ? 461  ARG B CA    1 ? 
ATOM   7738 C C     . ARG B 1 482 ? -46.347 48.058  31.744 1.00 27.25  ? 461  ARG B C     1 ? 
ATOM   7739 O O     . ARG B 1 482 ? -46.987 47.062  32.113 1.00 25.73  ? 461  ARG B O     1 ? 
ATOM   7740 C CB    . ARG B 1 482 ? -44.954 48.996  33.563 1.00 22.43  ? 461  ARG B CB    1 ? 
ATOM   7741 C CG    . ARG B 1 482 ? -43.598 49.028  34.242 1.00 21.17  ? 461  ARG B CG    1 ? 
ATOM   7742 C CD    . ARG B 1 482 ? -43.703 49.393  35.708 1.00 24.27  ? 461  ARG B CD    1 ? 
ATOM   7743 N NE    . ARG B 1 482 ? -42.350 49.569  36.247 1.00 25.18  ? 461  ARG B NE    1 ? 
ATOM   7744 C CZ    . ARG B 1 482 ? -41.585 48.594  36.710 1.00 27.25  ? 461  ARG B CZ    1 ? 
ATOM   7745 N NH1   . ARG B 1 482 ? -42.035 47.353  36.761 1.00 24.49  ? 461  ARG B NH1   1 ? 
ATOM   7746 N NH2   . ARG B 1 482 ? -40.386 48.878  37.186 1.00 28.52  ? 461  ARG B NH2   1 ? 
ATOM   7747 N N     . ASN B 1 483 ? -46.863 49.048  30.991 1.00 24.22  ? 462  ASN B N     1 ? 
ATOM   7748 C CA    . ASN B 1 483 ? -48.227 49.021  30.493 1.00 26.67  ? 462  ASN B CA    1 ? 
ATOM   7749 C C     . ASN B 1 483 ? -48.417 48.213  29.205 1.00 25.06  ? 462  ASN B C     1 ? 
ATOM   7750 O O     . ASN B 1 483 ? -49.529 47.776  28.967 1.00 24.03  ? 462  ASN B O     1 ? 
ATOM   7751 C CB    . ASN B 1 483 ? -48.756 50.419  30.194 1.00 30.37  ? 462  ASN B CB    1 ? 
ATOM   7752 C CG    . ASN B 1 483 ? -49.395 51.028  31.411 1.00 41.41  ? 462  ASN B CG    1 ? 
ATOM   7753 O OD1   . ASN B 1 483 ? -50.066 50.324  32.179 1.00 44.28  ? 462  ASN B OD1   1 ? 
ATOM   7754 N ND2   . ASN B 1 483 ? -49.186 52.319  31.604 1.00 47.95  ? 462  ASN B ND2   1 ? 
ATOM   7755 N N     . GLU B 1 484 ? -47.370 48.068  28.379 1.00 22.26  ? 463  GLU B N     1 ? 
ATOM   7756 C CA    . GLU B 1 484 ? -47.528 47.557  27.032 1.00 23.34  ? 463  GLU B CA    1 ? 
ATOM   7757 C C     . GLU B 1 484 ? -46.690 46.320  26.757 1.00 22.29  ? 463  GLU B C     1 ? 
ATOM   7758 O O     . GLU B 1 484 ? -46.914 45.664  25.755 1.00 24.36  ? 463  GLU B O     1 ? 
ATOM   7759 C CB    . GLU B 1 484 ? -47.122 48.630  26.022 1.00 25.27  ? 463  GLU B CB    1 ? 
ATOM   7760 C CG    . GLU B 1 484 ? -48.011 49.863  26.118 1.00 26.47  ? 463  GLU B CG    1 ? 
ATOM   7761 C CD    . GLU B 1 484 ? -47.640 51.046  25.239 1.00 29.55  ? 463  GLU B CD    1 ? 
ATOM   7762 O OE1   . GLU B 1 484 ? -48.297 52.091  25.457 1.00 29.30  ? 463  GLU B OE1   1 ? 
ATOM   7763 O OE2   . GLU B 1 484 ? -46.725 50.945  24.397 1.00 25.61  ? 463  GLU B OE2   1 ? 
ATOM   7764 N N     . ALA B 1 485 ? -45.634 46.050  27.523 1.00 22.23  ? 464  ALA B N     1 ? 
ATOM   7765 C CA    . ALA B 1 485 ? -44.799 44.897  27.205 1.00 21.78  ? 464  ALA B CA    1 ? 
ATOM   7766 C C     . ALA B 1 485 ? -45.635 43.626  27.398 1.00 22.75  ? 464  ALA B C     1 ? 
ATOM   7767 O O     . ALA B 1 485 ? -46.543 43.617  28.228 1.00 19.15  ? 464  ALA B O     1 ? 
ATOM   7768 C CB    . ALA B 1 485 ? -43.580 44.866  28.089 1.00 21.74  ? 464  ALA B CB    1 ? 
ATOM   7769 N N     . SER B 1 486 ? -45.313 42.556  26.666 1.00 22.27  ? 465  SER B N     1 ? 
ATOM   7770 C CA    . SER B 1 486 ? -46.101 41.335  26.781 1.00 22.53  ? 465  SER B CA    1 ? 
ATOM   7771 C C     . SER B 1 486 ? -45.235 40.122  26.464 1.00 19.96  ? 465  SER B C     1 ? 
ATOM   7772 O O     . SER B 1 486 ? -44.125 40.254  25.937 1.00 19.36  ? 465  SER B O     1 ? 
ATOM   7773 C CB    . SER B 1 486 ? -47.333 41.404  25.918 1.00 24.14  ? 465  SER B CB    1 ? 
ATOM   7774 O OG    . SER B 1 486 ? -48.235 40.339  26.221 1.00 24.85  ? 465  SER B OG    1 ? 
ATOM   7775 N N     . THR B 1 487 ? -45.769 38.943  26.803 1.00 16.60  ? 466  THR B N     1 ? 
ATOM   7776 C CA    . THR B 1 487 ? -45.087 37.688  26.589 1.00 17.14  ? 466  THR B CA    1 ? 
ATOM   7777 C C     . THR B 1 487 ? -44.789 37.493  25.108 1.00 18.04  ? 466  THR B C     1 ? 
ATOM   7778 O O     . THR B 1 487 ? -45.579 37.878  24.239 1.00 20.10  ? 466  THR B O     1 ? 
ATOM   7779 C CB    . THR B 1 487 ? -45.916 36.530  27.145 1.00 17.42  ? 466  THR B CB    1 ? 
ATOM   7780 O OG1   . THR B 1 487 ? -45.240 35.305  26.881 1.00 15.74  ? 466  THR B OG1   1 ? 
ATOM   7781 C CG2   . THR B 1 487 ? -47.287 36.453  26.513 1.00 16.98  ? 466  THR B CG2   1 ? 
ATOM   7782 N N     . VAL B 1 488 ? -43.629 36.890  24.841 1.00 18.16  ? 467  VAL B N     1 ? 
ATOM   7783 C CA    . VAL B 1 488 ? -43.312 36.454  23.490 1.00 20.39  ? 467  VAL B CA    1 ? 
ATOM   7784 C C     . VAL B 1 488 ? -43.642 34.965  23.331 1.00 20.26  ? 467  VAL B C     1 ? 
ATOM   7785 O O     . VAL B 1 488 ? -43.232 34.348  22.345 1.00 19.72  ? 467  VAL B O     1 ? 
ATOM   7786 C CB    . VAL B 1 488 ? -41.852 36.760  23.134 1.00 23.30  ? 467  VAL B CB    1 ? 
ATOM   7787 C CG1   . VAL B 1 488 ? -41.635 36.663  21.625 1.00 28.05  ? 467  VAL B CG1   1 ? 
ATOM   7788 C CG2   . VAL B 1 488 ? -41.445 38.154  23.644 1.00 23.07  ? 467  VAL B CG2   1 ? 
ATOM   7789 N N     . PHE B 1 489 ? -44.346 34.383  24.321 1.00 17.92  ? 468  PHE B N     1 ? 
ATOM   7790 C CA    . PHE B 1 489 ? -44.858 33.016  24.258 1.00 17.84  ? 468  PHE B CA    1 ? 
ATOM   7791 C C     . PHE B 1 489 ? -43.705 32.009  24.312 1.00 19.13  ? 468  PHE B C     1 ? 
ATOM   7792 O O     . PHE B 1 489 ? -43.796 30.940  23.710 1.00 19.36  ? 468  PHE B O     1 ? 
ATOM   7793 C CB    . PHE B 1 489 ? -45.760 32.806  23.028 1.00 21.33  ? 468  PHE B CB    1 ? 
ATOM   7794 C CG    . PHE B 1 489 ? -46.795 33.912  22.833 1.00 20.51  ? 468  PHE B CG    1 ? 
ATOM   7795 C CD1   . PHE B 1 489 ? -47.876 34.053  23.703 1.00 19.50  ? 468  PHE B CD1   1 ? 
ATOM   7796 C CD2   . PHE B 1 489 ? -46.684 34.815  21.785 1.00 21.67  ? 468  PHE B CD2   1 ? 
ATOM   7797 C CE1   . PHE B 1 489 ? -48.796 35.074  23.519 1.00 21.82  ? 468  PHE B CE1   1 ? 
ATOM   7798 C CE2   . PHE B 1 489 ? -47.592 35.848  21.624 1.00 22.57  ? 468  PHE B CE2   1 ? 
ATOM   7799 C CZ    . PHE B 1 489 ? -48.655 35.969  22.488 1.00 21.90  ? 468  PHE B CZ    1 ? 
ATOM   7800 N N     . HIS B 1 490 ? -42.671 32.287  25.131 1.00 18.56  ? 469  HIS B N     1 ? 
ATOM   7801 C CA    . HIS B 1 490 ? -41.528 31.393  25.252 1.00 19.14  ? 469  HIS B CA    1 ? 
ATOM   7802 C C     . HIS B 1 490 ? -41.338 30.848  26.661 1.00 19.21  ? 469  HIS B C     1 ? 
ATOM   7803 O O     . HIS B 1 490 ? -40.224 30.867  27.179 1.00 19.33  ? 469  HIS B O     1 ? 
ATOM   7804 C CB    . HIS B 1 490 ? -40.235 32.097  24.793 1.00 19.83  ? 469  HIS B CB    1 ? 
ATOM   7805 C CG    . HIS B 1 490 ? -40.279 32.615  23.401 1.00 18.69  ? 469  HIS B CG    1 ? 
ATOM   7806 N ND1   . HIS B 1 490 ? -39.425 33.613  22.977 1.00 19.30  ? 469  HIS B ND1   1 ? 
ATOM   7807 C CD2   . HIS B 1 490 ? -41.006 32.265  22.326 1.00 20.99  ? 469  HIS B CD2   1 ? 
ATOM   7808 C CE1   . HIS B 1 490 ? -39.681 33.900  21.713 1.00 20.49  ? 469  HIS B CE1   1 ? 
ATOM   7809 N NE2   . HIS B 1 490 ? -40.640 33.087  21.284 1.00 21.90  ? 469  HIS B NE2   1 ? 
ATOM   7810 N N     . PRO B 1 491 ? -42.375 30.326  27.361 1.00 19.26  ? 470  PRO B N     1 ? 
ATOM   7811 C CA    . PRO B 1 491 ? -42.160 29.835  28.716 1.00 19.66  ? 470  PRO B CA    1 ? 
ATOM   7812 C C     . PRO B 1 491 ? -41.302 28.571  28.733 1.00 19.57  ? 470  PRO B C     1 ? 
ATOM   7813 O O     . PRO B 1 491 ? -41.544 27.646  27.963 1.00 17.36  ? 470  PRO B O     1 ? 
ATOM   7814 C CB    . PRO B 1 491 ? -43.575 29.573  29.208 1.00 18.31  ? 470  PRO B CB    1 ? 
ATOM   7815 C CG    . PRO B 1 491 ? -44.331 29.216  27.958 1.00 19.24  ? 470  PRO B CG    1 ? 
ATOM   7816 C CD    . PRO B 1 491 ? -43.758 30.141  26.901 1.00 20.13  ? 470  PRO B CD    1 ? 
ATOM   7817 N N     . VAL B 1 492 ? -40.349 28.533  29.675 1.00 18.04  ? 471  VAL B N     1 ? 
ATOM   7818 C CA    . VAL B 1 492 ? -39.450 27.408  29.836 1.00 17.08  ? 471  VAL B CA    1 ? 
ATOM   7819 C C     . VAL B 1 492 ? -39.190 27.215  31.317 1.00 16.02  ? 471  VAL B C     1 ? 
ATOM   7820 O O     . VAL B 1 492 ? -39.517 28.081  32.135 1.00 17.34  ? 471  VAL B O     1 ? 
ATOM   7821 C CB    . VAL B 1 492 ? -38.112 27.566  29.082 1.00 18.69  ? 471  VAL B CB    1 ? 
ATOM   7822 C CG1   . VAL B 1 492 ? -38.311 27.840  27.596 1.00 20.37  ? 471  VAL B CG1   1 ? 
ATOM   7823 C CG2   . VAL B 1 492 ? -37.198 28.605  29.741 1.00 20.56  ? 471  VAL B CG2   1 ? 
ATOM   7824 N N     . GLY B 1 493 ? -38.644 26.058  31.673 1.00 18.68  ? 472  GLY B N     1 ? 
ATOM   7825 C CA    . GLY B 1 493 ? -37.800 25.985  32.862 1.00 21.21  ? 472  GLY B CA    1 ? 
ATOM   7826 C C     . GLY B 1 493 ? -38.412 25.345  34.108 1.00 21.44  ? 472  GLY B C     1 ? 
ATOM   7827 O O     . GLY B 1 493 ? -37.716 25.234  35.122 1.00 21.54  ? 472  GLY B O     1 ? 
ATOM   7828 N N     . THR B 1 494 ? -39.670 24.892  34.028 1.00 21.07  ? 473  THR B N     1 ? 
ATOM   7829 C CA    . THR B 1 494 ? -40.411 24.409  35.183 1.00 21.15  ? 473  THR B CA    1 ? 
ATOM   7830 C C     . THR B 1 494 ? -40.098 22.953  35.549 1.00 22.53  ? 473  THR B C     1 ? 
ATOM   7831 O O     . THR B 1 494 ? -40.606 22.476  36.557 1.00 20.53  ? 473  THR B O     1 ? 
ATOM   7832 C CB    . THR B 1 494 ? -41.902 24.617  34.926 1.00 24.46  ? 473  THR B CB    1 ? 
ATOM   7833 O OG1   . THR B 1 494 ? -42.182 23.981  33.680 1.00 19.23  ? 473  THR B OG1   1 ? 
ATOM   7834 C CG2   . THR B 1 494 ? -42.282 26.089  34.991 1.00 22.00  ? 473  THR B CG2   1 ? 
ATOM   7835 N N     . ALA B 1 495 ? -39.301 22.247  34.738 1.00 20.04  ? 474  ALA B N     1 ? 
ATOM   7836 C CA    . ALA B 1 495 ? -38.755 20.946  35.118 1.00 23.02  ? 474  ALA B CA    1 ? 
ATOM   7837 C C     . ALA B 1 495 ? -37.299 20.881  34.655 1.00 21.96  ? 474  ALA B C     1 ? 
ATOM   7838 O O     . ALA B 1 495 ? -36.895 20.029  33.885 1.00 19.77  ? 474  ALA B O     1 ? 
ATOM   7839 C CB    . ALA B 1 495 ? -39.606 19.798  34.571 1.00 24.30  ? 474  ALA B CB    1 ? 
ATOM   7840 N N     . ARG B 1 496 ? -36.503 21.812  35.199 1.00 22.45  ? 475  ARG B N     1 ? 
ATOM   7841 C CA    . ARG B 1 496 ? -35.195 22.156  34.694 1.00 21.53  ? 475  ARG B CA    1 ? 
ATOM   7842 C C     . ARG B 1 496 ? -34.255 20.944  34.676 1.00 22.34  ? 475  ARG B C     1 ? 
ATOM   7843 O O     . ARG B 1 496 ? -34.101 20.230  35.659 1.00 23.63  ? 475  ARG B O     1 ? 
ATOM   7844 C CB    . ARG B 1 496 ? -34.559 23.256  35.560 1.00 22.51  ? 475  ARG B CB    1 ? 
ATOM   7845 C CG    . ARG B 1 496 ? -33.168 23.637  35.084 1.00 23.81  ? 475  ARG B CG    1 ? 
ATOM   7846 C CD    . ARG B 1 496 ? -32.646 24.906  35.749 1.00 24.10  ? 475  ARG B CD    1 ? 
ATOM   7847 N NE    . ARG B 1 496 ? -32.598 24.854  37.207 1.00 26.38  ? 475  ARG B NE    1 ? 
ATOM   7848 C CZ    . ARG B 1 496 ? -31.621 24.254  37.902 1.00 29.55  ? 475  ARG B CZ    1 ? 
ATOM   7849 N NH1   . ARG B 1 496 ? -30.635 23.642  37.269 1.00 30.04  ? 475  ARG B NH1   1 ? 
ATOM   7850 N NH2   . ARG B 1 496 ? -31.651 24.248  39.212 1.00 29.30  ? 475  ARG B NH2   1 ? 
ATOM   7851 N N     . MET B 1 497 ? -33.582 20.762  33.542 1.00 21.66  ? 476  MET B N     1 ? 
ATOM   7852 C CA    . MET B 1 497 ? -32.537 19.757  33.426 1.00 24.16  ? 476  MET B CA    1 ? 
ATOM   7853 C C     . MET B 1 497 ? -31.226 20.313  34.001 1.00 26.33  ? 476  MET B C     1 ? 
ATOM   7854 O O     . MET B 1 497 ? -30.806 21.431  33.677 1.00 24.34  ? 476  MET B O     1 ? 
ATOM   7855 C CB    . MET B 1 497 ? -32.280 19.433  31.960 1.00 23.66  ? 476  MET B CB    1 ? 
ATOM   7856 C CG    . MET B 1 497 ? -31.173 18.419  31.765 1.00 24.92  ? 476  MET B CG    1 ? 
ATOM   7857 S SD    . MET B 1 497 ? -31.019 18.003  30.031 1.00 29.50  ? 476  MET B SD    1 ? 
ATOM   7858 C CE    . MET B 1 497 ? -30.667 19.594  29.278 1.00 29.27  ? 476  MET B CE    1 ? 
ATOM   7859 N N     . GLY B 1 498 ? -30.587 19.530  34.869 1.00 25.91  ? 477  GLY B N     1 ? 
ATOM   7860 C CA    . GLY B 1 498 ? -29.260 19.902  35.359 1.00 30.62  ? 477  GLY B CA    1 ? 
ATOM   7861 C C     . GLY B 1 498 ? -28.612 18.747  36.123 1.00 29.91  ? 477  GLY B C     1 ? 
ATOM   7862 O O     . GLY B 1 498 ? -28.889 17.576  35.853 1.00 31.92  ? 477  GLY B O     1 ? 
ATOM   7863 N N     . ASP B 1 499 ? -27.746 19.117  37.064 1.00 31.21  ? 478  ASP B N     1 ? 
ATOM   7864 C CA    . ASP B 1 499 ? -26.942 18.175  37.822 1.00 30.84  ? 478  ASP B CA    1 ? 
ATOM   7865 C C     . ASP B 1 499 ? -27.696 17.844  39.095 1.00 29.95  ? 478  ASP B C     1 ? 
ATOM   7866 O O     . ASP B 1 499 ? -27.633 18.599  40.054 1.00 31.92  ? 478  ASP B O     1 ? 
ATOM   7867 C CB    . ASP B 1 499 ? -25.570 18.756  38.153 1.00 34.07  ? 478  ASP B CB    1 ? 
ATOM   7868 C CG    . ASP B 1 499 ? -24.647 17.873  38.995 1.00 37.64  ? 478  ASP B CG    1 ? 
ATOM   7869 O OD1   . ASP B 1 499 ? -25.098 16.797  39.431 1.00 36.04  ? 478  ASP B OD1   1 ? 
ATOM   7870 O OD2   . ASP B 1 499 ? -23.503 18.294  39.220 1.00 39.26  ? 478  ASP B OD2   1 ? 
ATOM   7871 N N     . VAL B 1 500 ? -28.392 16.699  39.091 1.00 29.04  ? 479  VAL B N     1 ? 
ATOM   7872 C CA    . VAL B 1 500 ? -29.269 16.366  40.203 1.00 29.21  ? 479  VAL B CA    1 ? 
ATOM   7873 C C     . VAL B 1 500 ? -28.460 15.879  41.417 1.00 35.10  ? 479  VAL B C     1 ? 
ATOM   7874 O O     . VAL B 1 500 ? -29.025 15.663  42.475 1.00 33.63  ? 479  VAL B O     1 ? 
ATOM   7875 C CB    . VAL B 1 500 ? -30.347 15.350  39.781 1.00 28.10  ? 479  VAL B CB    1 ? 
ATOM   7876 C CG1   . VAL B 1 500 ? -31.277 15.914  38.688 1.00 27.86  ? 479  VAL B CG1   1 ? 
ATOM   7877 C CG2   . VAL B 1 500 ? -29.758 14.016  39.370 1.00 29.44  ? 479  VAL B CG2   1 ? 
ATOM   7878 N N     . GLU B 1 501 ? -27.145 15.689  41.270 1.00 40.83  ? 480  GLU B N     1 ? 
ATOM   7879 C CA    . GLU B 1 501 ? -26.296 15.256  42.378 1.00 39.51  ? 480  GLU B CA    1 ? 
ATOM   7880 C C     . GLU B 1 501 ? -25.919 16.453  43.250 1.00 39.29  ? 480  GLU B C     1 ? 
ATOM   7881 O O     . GLU B 1 501 ? -25.865 16.326  44.466 1.00 45.61  ? 480  GLU B O     1 ? 
ATOM   7882 C CB    . GLU B 1 501 ? -25.016 14.573  41.890 1.00 40.00  ? 480  GLU B CB    1 ? 
ATOM   7883 C CG    . GLU B 1 501 ? -25.255 13.322  41.052 1.00 38.51  ? 480  GLU B CG    1 ? 
ATOM   7884 C CD    . GLU B 1 501 ? -26.103 12.287  41.746 1.00 42.92  ? 480  GLU B CD    1 ? 
ATOM   7885 O OE1   . GLU B 1 501 ? -26.953 11.674  41.074 1.00 47.76  ? 480  GLU B OE1   1 ? 
ATOM   7886 O OE2   . GLU B 1 501 ? -25.943 12.115  42.969 1.00 45.40  ? 480  GLU B OE2   1 ? 
ATOM   7887 N N     . ASN B 1 502 ? -25.708 17.622  42.638 1.00 39.21  ? 481  ASN B N     1 ? 
ATOM   7888 C CA    . ASN B 1 502 ? -25.147 18.780  43.327 1.00 40.06  ? 481  ASN B CA    1 ? 
ATOM   7889 C C     . ASN B 1 502 ? -26.091 19.983  43.311 1.00 41.40  ? 481  ASN B C     1 ? 
ATOM   7890 O O     . ASN B 1 502 ? -25.831 20.985  43.976 1.00 39.52  ? 481  ASN B O     1 ? 
ATOM   7891 C CB    . ASN B 1 502 ? -23.805 19.151  42.701 1.00 42.38  ? 481  ASN B CB    1 ? 
ATOM   7892 C CG    . ASN B 1 502 ? -22.843 17.997  42.838 1.00 44.43  ? 481  ASN B CG    1 ? 
ATOM   7893 O OD1   . ASN B 1 502 ? -22.538 17.604  43.965 1.00 47.30  ? 481  ASN B OD1   1 ? 
ATOM   7894 N ND2   . ASN B 1 502 ? -22.443 17.395  41.731 1.00 45.02  ? 481  ASN B ND2   1 ? 
ATOM   7895 N N     . ASP B 1 503 ? -27.197 19.902  42.563 1.00 31.93  ? 482  ASP B N     1 ? 
ATOM   7896 C CA    . ASP B 1 503 ? -28.098 21.033  42.451 1.00 30.49  ? 482  ASP B CA    1 ? 
ATOM   7897 C C     . ASP B 1 503 ? -29.458 20.597  42.981 1.00 30.35  ? 482  ASP B C     1 ? 
ATOM   7898 O O     . ASP B 1 503 ? -30.149 19.841  42.302 1.00 28.82  ? 482  ASP B O     1 ? 
ATOM   7899 C CB    . ASP B 1 503 ? -28.096 21.499  41.002 1.00 28.52  ? 482  ASP B CB    1 ? 
ATOM   7900 C CG    . ASP B 1 503 ? -28.976 22.684  40.660 1.00 28.33  ? 482  ASP B CG    1 ? 
ATOM   7901 O OD1   . ASP B 1 503 ? -29.801 23.068  41.498 1.00 26.87  ? 482  ASP B OD1   1 ? 
ATOM   7902 O OD2   . ASP B 1 503 ? -28.772 23.220  39.548 1.00 31.45  ? 482  ASP B OD2   1 ? 
ATOM   7903 N N     . SER B 1 504 ? -29.852 21.086  44.164 1.00 27.27  ? 483  SER B N     1 ? 
ATOM   7904 C CA    . SER B 1 504 ? -31.091 20.621  44.788 1.00 29.44  ? 483  SER B CA    1 ? 
ATOM   7905 C C     . SER B 1 504 ? -32.345 21.051  44.003 1.00 29.46  ? 483  SER B C     1 ? 
ATOM   7906 O O     . SER B 1 504 ? -33.427 20.466  44.194 1.00 23.21  ? 483  SER B O     1 ? 
ATOM   7907 C CB    . SER B 1 504 ? -31.181 21.063  46.214 1.00 32.88  ? 483  SER B CB    1 ? 
ATOM   7908 O OG    . SER B 1 504 ? -31.257 22.474  46.263 1.00 36.72  ? 483  SER B OG    1 ? 
ATOM   7909 N N     . LEU B 1 505 ? -32.213 22.047  43.103 1.00 26.17  ? 484  LEU B N     1 ? 
ATOM   7910 C CA    . LEU B 1 505 ? -33.365 22.561  42.361 1.00 28.84  ? 484  LEU B CA    1 ? 
ATOM   7911 C C     . LEU B 1 505 ? -33.433 22.007  40.936 1.00 27.01  ? 484  LEU B C     1 ? 
ATOM   7912 O O     . LEU B 1 505 ? -34.354 22.329  40.198 1.00 24.07  ? 484  LEU B O     1 ? 
ATOM   7913 C CB    . LEU B 1 505 ? -33.318 24.091  42.366 1.00 31.09  ? 484  LEU B CB    1 ? 
ATOM   7914 C CG    . LEU B 1 505 ? -33.597 24.745  43.725 1.00 33.81  ? 484  LEU B CG    1 ? 
ATOM   7915 C CD1   . LEU B 1 505 ? -33.311 26.247  43.703 1.00 33.66  ? 484  LEU B CD1   1 ? 
ATOM   7916 C CD2   . LEU B 1 505 ? -35.039 24.471  44.102 1.00 35.57  ? 484  LEU B CD2   1 ? 
ATOM   7917 N N     . ALA B 1 506 ? -32.477 21.169  40.529 1.00 25.99  ? 485  ALA B N     1 ? 
ATOM   7918 C CA    . ALA B 1 506 ? -32.604 20.511  39.236 1.00 25.49  ? 485  ALA B CA    1 ? 
ATOM   7919 C C     . ALA B 1 506 ? -33.682 19.439  39.357 1.00 24.10  ? 485  ALA B C     1 ? 
ATOM   7920 O O     . ALA B 1 506 ? -33.847 18.833  40.432 1.00 24.44  ? 485  ALA B O     1 ? 
ATOM   7921 C CB    . ALA B 1 506 ? -31.271 19.951  38.767 1.00 26.87  ? 485  ALA B CB    1 ? 
ATOM   7922 N N     . VAL B 1 507 ? -34.428 19.245  38.253 1.00 20.57  ? 486  VAL B N     1 ? 
ATOM   7923 C CA    . VAL B 1 507 ? -35.566 18.353  38.273 1.00 20.90  ? 486  VAL B CA    1 ? 
ATOM   7924 C C     . VAL B 1 507 ? -35.223 17.078  37.528 1.00 22.73  ? 486  VAL B C     1 ? 
ATOM   7925 O O     . VAL B 1 507 ? -35.473 15.980  38.037 1.00 25.30  ? 486  VAL B O     1 ? 
ATOM   7926 C CB    . VAL B 1 507 ? -36.843 18.989  37.701 1.00 19.63  ? 486  VAL B CB    1 ? 
ATOM   7927 C CG1   . VAL B 1 507 ? -38.007 17.999  37.619 1.00 18.95  ? 486  VAL B CG1   1 ? 
ATOM   7928 C CG2   . VAL B 1 507 ? -37.228 20.217  38.518 1.00 19.52  ? 486  VAL B CG2   1 ? 
ATOM   7929 N N     . VAL B 1 508 ? -34.660 17.231  36.332 1.00 23.82  ? 487  VAL B N     1 ? 
ATOM   7930 C CA    . VAL B 1 508 ? -34.257 16.061  35.567 1.00 24.31  ? 487  VAL B CA    1 ? 
ATOM   7931 C C     . VAL B 1 508 ? -32.752 16.109  35.342 1.00 27.34  ? 487  VAL B C     1 ? 
ATOM   7932 O O     . VAL B 1 508 ? -32.143 17.173  35.331 1.00 26.56  ? 487  VAL B O     1 ? 
ATOM   7933 C CB    . VAL B 1 508 ? -35.011 15.887  34.230 1.00 23.27  ? 487  VAL B CB    1 ? 
ATOM   7934 C CG1   . VAL B 1 508 ? -36.512 15.794  34.436 1.00 25.43  ? 487  VAL B CG1   1 ? 
ATOM   7935 C CG2   . VAL B 1 508 ? -34.657 16.958  33.214 1.00 21.16  ? 487  VAL B CG2   1 ? 
ATOM   7936 N N     . ASP B 1 509 ? -32.162 14.922  35.138 1.00 26.80  ? 488  ASP B N     1 ? 
ATOM   7937 C CA    . ASP B 1 509 ? -30.737 14.814  34.889 1.00 27.82  ? 488  ASP B CA    1 ? 
ATOM   7938 C C     . ASP B 1 509 ? -30.493 14.951  33.392 1.00 30.99  ? 488  ASP B C     1 ? 
ATOM   7939 O O     . ASP B 1 509 ? -31.421 15.213  32.632 1.00 30.10  ? 488  ASP B O     1 ? 
ATOM   7940 C CB    . ASP B 1 509 ? -30.160 13.543  35.502 1.00 28.20  ? 488  ASP B CB    1 ? 
ATOM   7941 C CG    . ASP B 1 509 ? -30.681 12.225  34.963 1.00 31.50  ? 488  ASP B CG    1 ? 
ATOM   7942 O OD1   . ASP B 1 509 ? -31.196 12.216  33.809 1.00 31.59  ? 488  ASP B OD1   1 ? 
ATOM   7943 O OD2   . ASP B 1 509 ? -30.628 11.224  35.727 1.00 35.72  ? 488  ASP B OD2   1 ? 
ATOM   7944 N N     . SER B 1 510 ? -29.234 14.736  33.006 1.00 30.52  ? 489  SER B N     1 ? 
ATOM   7945 C CA    . SER B 1 510 ? -28.737 14.805  31.638 1.00 37.30  ? 489  SER B CA    1 ? 
ATOM   7946 C C     . SER B 1 510 ? -29.413 13.798  30.720 1.00 29.69  ? 489  SER B C     1 ? 
ATOM   7947 O O     . SER B 1 510 ? -29.384 13.975  29.505 1.00 27.80  ? 489  SER B O     1 ? 
ATOM   7948 C CB    . SER B 1 510 ? -27.260 14.544  31.636 1.00 46.15  ? 489  SER B CB    1 ? 
ATOM   7949 O OG    . SER B 1 510 ? -26.580 15.650  32.214 1.00 62.53  ? 489  SER B OG    1 ? 
ATOM   7950 N N     . SER B 1 511 ? -29.962 12.730  31.306 1.00 25.60  ? 490  SER B N     1 ? 
ATOM   7951 C CA    . SER B 1 511 ? -30.723 11.740  30.555 1.00 28.91  ? 490  SER B CA    1 ? 
ATOM   7952 C C     . SER B 1 511 ? -32.230 12.030  30.541 1.00 28.16  ? 490  SER B C     1 ? 
ATOM   7953 O O     . SER B 1 511 ? -33.009 11.242  30.018 1.00 30.23  ? 490  SER B O     1 ? 
ATOM   7954 C CB    . SER B 1 511 ? -30.464 10.362  31.119 1.00 32.22  ? 490  SER B CB    1 ? 
ATOM   7955 O OG    . SER B 1 511 ? -29.118 10.019  30.866 1.00 34.04  ? 490  SER B OG    1 ? 
ATOM   7956 N N     . LEU B 1 512 ? -32.640 13.158  31.122 1.00 29.61  ? 491  LEU B N     1 ? 
ATOM   7957 C CA    . LEU B 1 512 ? -34.026 13.622  31.146 1.00 27.26  ? 491  LEU B CA    1 ? 
ATOM   7958 C C     . LEU B 1 512 ? -34.844 12.825  32.158 1.00 28.44  ? 491  LEU B C     1 ? 
ATOM   7959 O O     . LEU B 1 512 ? -36.066 12.931  32.179 1.00 26.62  ? 491  LEU B O     1 ? 
ATOM   7960 C CB    . LEU B 1 512 ? -34.672 13.621  29.763 1.00 23.27  ? 491  LEU B CB    1 ? 
ATOM   7961 C CG    . LEU B 1 512 ? -33.966 14.475  28.712 1.00 24.72  ? 491  LEU B CG    1 ? 
ATOM   7962 C CD1   . LEU B 1 512 ? -34.589 14.340  27.353 1.00 27.56  ? 491  LEU B CD1   1 ? 
ATOM   7963 C CD2   . LEU B 1 512 ? -33.947 15.911  29.138 1.00 28.23  ? 491  LEU B CD2   1 ? 
ATOM   7964 N N     . LYS B 1 513 ? -34.164 12.073  33.035 1.00 28.87  ? 492  LYS B N     1 ? 
ATOM   7965 C CA    . LYS B 1 513 ? -34.846 11.293  34.043 1.00 28.21  ? 492  LYS B CA    1 ? 
ATOM   7966 C C     . LYS B 1 513 ? -35.152 12.160  35.247 1.00 27.91  ? 492  LYS B C     1 ? 
ATOM   7967 O O     . LYS B 1 513 ? -34.280 12.860  35.755 1.00 30.15  ? 492  LYS B O     1 ? 
ATOM   7968 C CB    . LYS B 1 513 ? -34.013 10.095  34.504 1.00 30.11  ? 492  LYS B CB    1 ? 
ATOM   7969 C CG    . LYS B 1 513 ? -33.828 9.071   33.413 1.00 34.42  ? 492  LYS B CG    1 ? 
ATOM   7970 C CD    . LYS B 1 513 ? -33.044 7.867   33.903 1.00 38.74  ? 492  LYS B CD    1 ? 
ATOM   7971 C CE    . LYS B 1 513 ? -32.673 6.991   32.759 1.00 41.79  ? 492  LYS B CE    1 ? 
ATOM   7972 N NZ    . LYS B 1 513 ? -31.969 5.817   33.281 1.00 42.17  ? 492  LYS B NZ    1 ? 
ATOM   7973 N N     . VAL B 1 514 ? -36.380 12.019  35.745 1.00 26.84  ? 493  VAL B N     1 ? 
ATOM   7974 C CA    . VAL B 1 514 ? -36.814 12.725  36.922 1.00 26.51  ? 493  VAL B CA    1 ? 
ATOM   7975 C C     . VAL B 1 514 ? -36.109 12.126  38.131 1.00 28.99  ? 493  VAL B C     1 ? 
ATOM   7976 O O     . VAL B 1 514 ? -36.099 10.914  38.329 1.00 28.58  ? 493  VAL B O     1 ? 
ATOM   7977 C CB    . VAL B 1 514 ? -38.346 12.708  37.092 1.00 28.04  ? 493  VAL B CB    1 ? 
ATOM   7978 C CG1   . VAL B 1 514 ? -38.771 13.318  38.439 1.00 26.62  ? 493  VAL B CG1   1 ? 
ATOM   7979 C CG2   . VAL B 1 514 ? -39.030 13.406  35.913 1.00 25.73  ? 493  VAL B CG2   1 ? 
ATOM   7980 N N     . ARG B 1 515 ? -35.537 13.032  38.915 1.00 26.57  ? 494  ARG B N     1 ? 
ATOM   7981 C CA    . ARG B 1 515 ? -34.899 12.730  40.174 1.00 33.89  ? 494  ARG B CA    1 ? 
ATOM   7982 C C     . ARG B 1 515 ? -35.810 11.955  41.125 1.00 28.13  ? 494  ARG B C     1 ? 
ATOM   7983 O O     . ARG B 1 515 ? -36.943 12.346  41.356 1.00 28.74  ? 494  ARG B O     1 ? 
ATOM   7984 C CB    . ARG B 1 515 ? -34.590 14.153  40.622 1.00 37.11  ? 494  ARG B CB    1 ? 
ATOM   7985 C CG    . ARG B 1 515 ? -34.556 14.430  42.098 1.00 44.77  ? 494  ARG B CG    1 ? 
ATOM   7986 C CD    . ARG B 1 515 ? -34.117 15.887  42.190 1.00 45.88  ? 494  ARG B CD    1 ? 
ATOM   7987 N NE    . ARG B 1 515 ? -33.089 15.897  43.223 1.00 41.78  ? 494  ARG B NE    1 ? 
ATOM   7988 C CZ    . ARG B 1 515 ? -32.030 16.680  43.251 1.00 43.86  ? 494  ARG B CZ    1 ? 
ATOM   7989 N NH1   . ARG B 1 515 ? -31.904 17.708  42.415 1.00 38.49  ? 494  ARG B NH1   1 ? 
ATOM   7990 N NH2   . ARG B 1 515 ? -31.136 16.433  44.189 1.00 41.75  ? 494  ARG B NH2   1 ? 
ATOM   7991 N N     . GLY B 1 516 ? -35.268 10.897  41.729 1.00 30.01  ? 495  GLY B N     1 ? 
ATOM   7992 C CA    . GLY B 1 516 ? -35.971 10.149  42.762 1.00 28.79  ? 495  GLY B CA    1 ? 
ATOM   7993 C C     . GLY B 1 516 ? -36.945 9.118   42.172 1.00 29.61  ? 495  GLY B C     1 ? 
ATOM   7994 O O     . GLY B 1 516 ? -37.675 8.476   42.909 1.00 32.34  ? 495  GLY B O     1 ? 
ATOM   7995 N N     . ILE B 1 517 ? -36.971 8.985   40.843 1.00 28.79  ? 496  ILE B N     1 ? 
ATOM   7996 C CA    . ILE B 1 517 ? -38.006 8.221   40.171 1.00 29.97  ? 496  ILE B CA    1 ? 
ATOM   7997 C C     . ILE B 1 517 ? -37.344 7.366   39.108 1.00 26.73  ? 496  ILE B C     1 ? 
ATOM   7998 O O     . ILE B 1 517 ? -36.424 7.839   38.445 1.00 29.51  ? 496  ILE B O     1 ? 
ATOM   7999 C CB    . ILE B 1 517 ? -39.062 9.141   39.519 1.00 29.89  ? 496  ILE B CB    1 ? 
ATOM   8000 C CG1   . ILE B 1 517 ? -39.733 10.042  40.526 1.00 29.20  ? 496  ILE B CG1   1 ? 
ATOM   8001 C CG2   . ILE B 1 517 ? -40.080 8.307   38.736 1.00 29.17  ? 496  ILE B CG2   1 ? 
ATOM   8002 C CD1   . ILE B 1 517 ? -40.561 9.308   41.563 1.00 33.03  ? 496  ILE B CD1   1 ? 
ATOM   8003 N N     . GLN B 1 518 ? -37.890 6.157   38.892 1.00 26.00  ? 497  GLN B N     1 ? 
ATOM   8004 C CA    . GLN B 1 518 ? -37.437 5.328   37.778 1.00 26.35  ? 497  GLN B CA    1 ? 
ATOM   8005 C C     . GLN B 1 518 ? -38.538 5.254   36.732 1.00 23.26  ? 497  GLN B C     1 ? 
ATOM   8006 O O     . GLN B 1 518 ? -39.697 5.230   37.088 1.00 25.40  ? 497  GLN B O     1 ? 
ATOM   8007 C CB    . GLN B 1 518 ? -37.031 3.918   38.205 1.00 28.68  ? 497  GLN B CB    1 ? 
ATOM   8008 C CG    . GLN B 1 518 ? -35.903 3.896   39.231 1.00 29.59  ? 497  GLN B CG    1 ? 
ATOM   8009 C CD    . GLN B 1 518 ? -36.357 4.303   40.616 1.00 26.91  ? 497  GLN B CD    1 ? 
ATOM   8010 O OE1   . GLN B 1 518 ? -37.365 3.817   41.133 1.00 28.04  ? 497  GLN B OE1   1 ? 
ATOM   8011 N NE2   . GLN B 1 518 ? -35.638 5.225   41.237 1.00 33.06  ? 497  GLN B NE2   1 ? 
ATOM   8012 N N     . GLY B 1 519 ? -38.146 5.257   35.456 1.00 25.78  ? 498  GLY B N     1 ? 
ATOM   8013 C CA    . GLY B 1 519 ? -39.055 5.059   34.347 1.00 26.87  ? 498  GLY B CA    1 ? 
ATOM   8014 C C     . GLY B 1 519 ? -39.877 6.315   34.012 1.00 30.67  ? 498  GLY B C     1 ? 
ATOM   8015 O O     . GLY B 1 519 ? -40.936 6.180   33.393 1.00 31.74  ? 498  GLY B O     1 ? 
ATOM   8016 N N     . LEU B 1 520 ? -39.395 7.514   34.379 1.00 26.85  ? 499  LEU B N     1 ? 
ATOM   8017 C CA    . LEU B 1 520 ? -40.110 8.763   34.105 1.00 25.08  ? 499  LEU B CA    1 ? 
ATOM   8018 C C     . LEU B 1 520 ? -39.131 9.809   33.568 1.00 27.11  ? 499  LEU B C     1 ? 
ATOM   8019 O O     . LEU B 1 520 ? -38.142 10.164  34.241 1.00 25.56  ? 499  LEU B O     1 ? 
ATOM   8020 C CB    . LEU B 1 520 ? -40.811 9.284   35.358 1.00 24.74  ? 499  LEU B CB    1 ? 
ATOM   8021 C CG    . LEU B 1 520 ? -41.612 10.575  35.170 1.00 23.87  ? 499  LEU B CG    1 ? 
ATOM   8022 C CD1   . LEU B 1 520 ? -42.740 10.415  34.164 1.00 23.66  ? 499  LEU B CD1   1 ? 
ATOM   8023 C CD2   . LEU B 1 520 ? -42.147 11.071  36.499 1.00 26.35  ? 499  LEU B CD2   1 ? 
ATOM   8024 N N     . ARG B 1 521 ? -39.391 10.280  32.341 1.00 25.75  ? 500  ARG B N     1 ? 
ATOM   8025 C CA    . ARG B 1 521 ? -38.584 11.330  31.728 1.00 25.94  ? 500  ARG B CA    1 ? 
ATOM   8026 C C     . ARG B 1 521 ? -39.474 12.504  31.322 1.00 24.48  ? 500  ARG B C     1 ? 
ATOM   8027 O O     . ARG B 1 521 ? -40.692 12.346  31.158 1.00 21.36  ? 500  ARG B O     1 ? 
ATOM   8028 C CB    . ARG B 1 521 ? -37.849 10.815  30.486 1.00 28.05  ? 500  ARG B CB    1 ? 
ATOM   8029 C CG    . ARG B 1 521 ? -36.914 9.664   30.831 1.00 31.00  ? 500  ARG B CG    1 ? 
ATOM   8030 C CD    . ARG B 1 521 ? -35.972 9.352   29.699 1.00 30.39  ? 500  ARG B CD    1 ? 
ATOM   8031 N NE    . ARG B 1 521 ? -35.480 7.979   29.877 1.00 30.38  ? 500  ARG B NE    1 ? 
ATOM   8032 C CZ    . ARG B 1 521 ? -34.240 7.548   29.629 1.00 32.94  ? 500  ARG B CZ    1 ? 
ATOM   8033 N NH1   . ARG B 1 521 ? -33.249 8.393   29.425 1.00 28.17  ? 500  ARG B NH1   1 ? 
ATOM   8034 N NH2   . ARG B 1 521 ? -34.012 6.243   29.602 1.00 33.05  ? 500  ARG B NH2   1 ? 
ATOM   8035 N N     . VAL B 1 522 ? -38.841 13.668  31.151 1.00 20.83  ? 501  VAL B N     1 ? 
ATOM   8036 C CA    . VAL B 1 522 ? -39.526 14.859  30.693 1.00 20.90  ? 501  VAL B CA    1 ? 
ATOM   8037 C C     . VAL B 1 522 ? -38.744 15.333  29.477 1.00 20.01  ? 501  VAL B C     1 ? 
ATOM   8038 O O     . VAL B 1 522 ? -37.525 15.387  29.526 1.00 22.89  ? 501  VAL B O     1 ? 
ATOM   8039 C CB    . VAL B 1 522 ? -39.605 15.956  31.773 1.00 21.92  ? 501  VAL B CB    1 ? 
ATOM   8040 C CG1   . VAL B 1 522 ? -40.355 17.183  31.257 1.00 22.07  ? 501  VAL B CG1   1 ? 
ATOM   8041 C CG2   . VAL B 1 522 ? -40.206 15.433  33.074 1.00 22.28  ? 501  VAL B CG2   1 ? 
ATOM   8042 N N     . ALA B 1 523 ? -39.456 15.640  28.402 1.00 21.75  ? 502  ALA B N     1 ? 
ATOM   8043 C CA    . ALA B 1 523 ? -38.857 16.133  27.171 1.00 22.35  ? 502  ALA B CA    1 ? 
ATOM   8044 C C     . ALA B 1 523 ? -39.809 17.112  26.479 1.00 22.19  ? 502  ALA B C     1 ? 
ATOM   8045 O O     . ALA B 1 523 ? -40.706 16.702  25.732 1.00 21.90  ? 502  ALA B O     1 ? 
ATOM   8046 C CB    . ALA B 1 523 ? -38.499 14.992  26.267 1.00 19.84  ? 502  ALA B CB    1 ? 
ATOM   8047 N N     . ASP B 1 524 ? -39.578 18.397  26.766 1.00 21.74  ? 503  ASP B N     1 ? 
ATOM   8048 C CA    . ASP B 1 524 ? -40.358 19.514  26.265 1.00 21.55  ? 503  ASP B CA    1 ? 
ATOM   8049 C C     . ASP B 1 524 ? -39.671 20.795  26.739 1.00 19.34  ? 503  ASP B C     1 ? 
ATOM   8050 O O     . ASP B 1 524 ? -38.575 20.744  27.281 1.00 20.56  ? 503  ASP B O     1 ? 
ATOM   8051 C CB    . ASP B 1 524 ? -41.813 19.405  26.675 1.00 20.22  ? 503  ASP B CB    1 ? 
ATOM   8052 C CG    . ASP B 1 524 ? -42.086 19.434  28.167 1.00 19.34  ? 503  ASP B CG    1 ? 
ATOM   8053 O OD1   . ASP B 1 524 ? -41.234 19.946  28.914 1.00 19.95  ? 503  ASP B OD1   1 ? 
ATOM   8054 O OD2   . ASP B 1 524 ? -43.162 18.950  28.553 1.00 21.49  ? 503  ASP B OD2   1 ? 
ATOM   8055 N N     . ALA B 1 525 ? -40.320 21.941  26.577 1.00 20.06  ? 504  ALA B N     1 ? 
ATOM   8056 C CA    . ALA B 1 525 ? -39.703 23.220  26.914 1.00 17.63  ? 504  ALA B CA    1 ? 
ATOM   8057 C C     . ALA B 1 525 ? -39.458 23.320  28.417 1.00 18.11  ? 504  ALA B C     1 ? 
ATOM   8058 O O     . ALA B 1 525 ? -38.676 24.165  28.852 1.00 19.81  ? 504  ALA B O     1 ? 
ATOM   8059 C CB    . ALA B 1 525 ? -40.546 24.350  26.439 1.00 16.37  ? 504  ALA B CB    1 ? 
ATOM   8060 N N     . SER B 1 526 ? -40.150 22.489  29.220 1.00 18.21  ? 505  SER B N     1 ? 
ATOM   8061 C CA    . SER B 1 526 ? -40.025 22.603  30.666 1.00 19.61  ? 505  SER B CA    1 ? 
ATOM   8062 C C     . SER B 1 526 ? -38.600 22.311  31.138 1.00 19.34  ? 505  SER B C     1 ? 
ATOM   8063 O O     . SER B 1 526 ? -38.213 22.808  32.203 1.00 19.30  ? 505  SER B O     1 ? 
ATOM   8064 C CB    . SER B 1 526 ? -41.011 21.731  31.414 1.00 18.08  ? 505  SER B CB    1 ? 
ATOM   8065 O OG    . SER B 1 526 ? -40.702 20.350  31.261 1.00 19.71  ? 505  SER B OG    1 ? 
ATOM   8066 N N     . ILE B 1 527 ? -37.835 21.506  30.378 1.00 19.59  ? 506  ILE B N     1 ? 
ATOM   8067 C CA    . ILE B 1 527 ? -36.513 21.081  30.811 1.00 23.33  ? 506  ILE B CA    1 ? 
ATOM   8068 C C     . ILE B 1 527 ? -35.457 22.146  30.451 1.00 24.15  ? 506  ILE B C     1 ? 
ATOM   8069 O O     . ILE B 1 527 ? -34.370 22.144  31.002 1.00 24.42  ? 506  ILE B O     1 ? 
ATOM   8070 C CB    . ILE B 1 527 ? -36.150 19.682  30.282 1.00 25.38  ? 506  ILE B CB    1 ? 
ATOM   8071 C CG1   . ILE B 1 527 ? -35.857 19.661  28.779 1.00 26.78  ? 506  ILE B CG1   1 ? 
ATOM   8072 C CG2   . ILE B 1 527 ? -37.241 18.675  30.650 1.00 25.89  ? 506  ILE B CG2   1 ? 
ATOM   8073 C CD1   . ILE B 1 527 ? -34.415 19.951  28.422 1.00 29.04  ? 506  ILE B CD1   1 ? 
ATOM   8074 N N     . ILE B 1 528 ? -35.785 23.073  29.554 1.00 23.71  ? 507  ILE B N     1 ? 
ATOM   8075 C CA    . ILE B 1 528 ? -34.846 24.095  29.105 1.00 23.11  ? 507  ILE B CA    1 ? 
ATOM   8076 C C     . ILE B 1 528 ? -34.579 25.033  30.277 1.00 23.93  ? 507  ILE B C     1 ? 
ATOM   8077 O O     . ILE B 1 528 ? -35.529 25.549  30.858 1.00 23.65  ? 507  ILE B O     1 ? 
ATOM   8078 C CB    . ILE B 1 528 ? -35.410 24.844  27.887 1.00 21.88  ? 507  ILE B CB    1 ? 
ATOM   8079 C CG1   . ILE B 1 528 ? -35.538 23.885  26.718 1.00 22.65  ? 507  ILE B CG1   1 ? 
ATOM   8080 C CG2   . ILE B 1 528 ? -34.592 26.098  27.572 1.00 22.64  ? 507  ILE B CG2   1 ? 
ATOM   8081 C CD1   . ILE B 1 528 ? -36.085 24.444  25.423 1.00 25.04  ? 507  ILE B CD1   1 ? 
ATOM   8082 N N     . PRO B 1 529 ? -33.307 25.226  30.704 1.00 25.95  ? 508  PRO B N     1 ? 
ATOM   8083 C CA    . PRO B 1 529 ? -33.019 26.046  31.887 1.00 24.67  ? 508  PRO B CA    1 ? 
ATOM   8084 C C     . PRO B 1 529 ? -33.406 27.516  31.786 1.00 22.58  ? 508  PRO B C     1 ? 
ATOM   8085 O O     . PRO B 1 529 ? -33.862 28.128  32.759 1.00 23.48  ? 508  PRO B O     1 ? 
ATOM   8086 C CB    . PRO B 1 529 ? -31.504 25.866  32.089 1.00 26.78  ? 508  PRO B CB    1 ? 
ATOM   8087 C CG    . PRO B 1 529 ? -31.200 24.576  31.373 1.00 29.17  ? 508  PRO B CG    1 ? 
ATOM   8088 C CD    . PRO B 1 529 ? -32.104 24.579  30.145 1.00 25.28  ? 508  PRO B CD    1 ? 
ATOM   8089 N N     . ALA B 1 530 ? -33.189 28.079  30.608 1.00 21.90  ? 509  ALA B N     1 ? 
ATOM   8090 C CA    . ALA B 1 530 ? -33.352 29.493  30.397 1.00 23.24  ? 509  ALA B CA    1 ? 
ATOM   8091 C C     . ALA B 1 530 ? -33.686 29.752  28.934 1.00 23.13  ? 509  ALA B C     1 ? 
ATOM   8092 O O     . ALA B 1 530 ? -33.240 29.048  28.036 1.00 24.21  ? 509  ALA B O     1 ? 
ATOM   8093 C CB    . ALA B 1 530 ? -32.100 30.231  30.832 1.00 25.93  ? 509  ALA B CB    1 ? 
ATOM   8094 N N     . VAL B 1 531 ? -34.458 30.807  28.713 1.00 23.45  ? 510  VAL B N     1 ? 
ATOM   8095 C CA    . VAL B 1 531 ? -34.852 31.176  27.370 1.00 26.76  ? 510  VAL B CA    1 ? 
ATOM   8096 C C     . VAL B 1 531 ? -33.591 31.468  26.551 1.00 34.84  ? 510  VAL B C     1 ? 
ATOM   8097 O O     . VAL B 1 531 ? -32.552 31.842  27.106 1.00 33.41  ? 510  VAL B O     1 ? 
ATOM   8098 C CB    . VAL B 1 531 ? -35.816 32.376  27.401 1.00 27.24  ? 510  VAL B CB    1 ? 
ATOM   8099 C CG1   . VAL B 1 531 ? -37.196 31.978  27.919 1.00 26.59  ? 510  VAL B CG1   1 ? 
ATOM   8100 C CG2   . VAL B 1 531 ? -35.254 33.574  28.191 1.00 28.45  ? 510  VAL B CG2   1 ? 
ATOM   8101 N N     . ASN B 1 532 ? -33.697 31.283  25.224 1.00 35.80  ? 511  ASN B N     1 ? 
ATOM   8102 C CA    . ASN B 1 532 ? -32.545 31.394  24.331 1.00 34.41  ? 511  ASN B CA    1 ? 
ATOM   8103 C C     . ASN B 1 532 ? -32.484 32.827  23.785 1.00 38.60  ? 511  ASN B C     1 ? 
ATOM   8104 O O     . ASN B 1 532 ? -33.331 33.664  24.089 1.00 33.29  ? 511  ASN B O     1 ? 
ATOM   8105 C CB    . ASN B 1 532 ? -32.607 30.305  23.257 1.00 38.47  ? 511  ASN B CB    1 ? 
ATOM   8106 C CG    . ASN B 1 532 ? -33.877 30.335  22.420 1.00 37.77  ? 511  ASN B CG    1 ? 
ATOM   8107 O OD1   . ASN B 1 532 ? -34.949 30.659  22.949 1.00 35.28  ? 511  ASN B OD1   1 ? 
ATOM   8108 N ND2   . ASN B 1 532 ? -33.795 30.029  21.125 1.00 35.29  ? 511  ASN B ND2   1 ? 
ATOM   8109 N N     . ARG B 1 533 ? -31.455 33.114  22.977 1.00 33.66  ? 512  ARG B N     1 ? 
ATOM   8110 C CA    . ARG B 1 533 ? -31.378 34.337  22.195 1.00 32.37  ? 512  ARG B CA    1 ? 
ATOM   8111 C C     . ARG B 1 533 ? -32.098 34.064  20.878 1.00 35.40  ? 512  ARG B C     1 ? 
ATOM   8112 O O     . ARG B 1 533 ? -31.492 33.907  19.824 1.00 36.69  ? 512  ARG B O     1 ? 
ATOM   8113 C CB    . ARG B 1 533 ? -29.911 34.727  21.993 1.00 33.83  ? 512  ARG B CB    1 ? 
ATOM   8114 C CG    . ARG B 1 533 ? -29.223 35.023  23.324 1.00 32.86  ? 512  ARG B CG    1 ? 
ATOM   8115 C CD    . ARG B 1 533 ? -27.740 35.251  23.131 1.00 32.18  ? 512  ARG B CD    1 ? 
ATOM   8116 N NE    . ARG B 1 533 ? -27.106 35.787  24.339 1.00 31.16  ? 512  ARG B NE    1 ? 
ATOM   8117 C CZ    . ARG B 1 533 ? -26.704 35.048  25.367 1.00 34.21  ? 512  ARG B CZ    1 ? 
ATOM   8118 N NH1   . ARG B 1 533 ? -26.876 33.732  25.365 1.00 36.11  ? 512  ARG B NH1   1 ? 
ATOM   8119 N NH2   . ARG B 1 533 ? -26.088 35.624  26.379 1.00 39.53  ? 512  ARG B NH2   1 ? 
ATOM   8120 N N     . GLY B 1 534 ? -33.414 33.992  20.972 1.00 30.15  ? 513  GLY B N     1 ? 
ATOM   8121 C CA    . GLY B 1 534 ? -34.245 33.510  19.889 1.00 32.48  ? 513  GLY B CA    1 ? 
ATOM   8122 C C     . GLY B 1 534 ? -35.598 33.061  20.430 1.00 29.34  ? 513  GLY B C     1 ? 
ATOM   8123 O O     . GLY B 1 534 ? -36.061 33.599  21.446 1.00 31.31  ? 513  GLY B O     1 ? 
ATOM   8124 N N     . HIS B 1 535 ? -36.187 32.073  19.743 1.00 25.11  ? 514  HIS B N     1 ? 
ATOM   8125 C CA    . HIS B 1 535 ? -37.545 31.635  19.974 1.00 23.48  ? 514  HIS B CA    1 ? 
ATOM   8126 C C     . HIS B 1 535 ? -37.515 30.142  20.266 1.00 20.98  ? 514  HIS B C     1 ? 
ATOM   8127 O O     . HIS B 1 535 ? -36.669 29.450  19.721 1.00 22.25  ? 514  HIS B O     1 ? 
ATOM   8128 C CB    . HIS B 1 535 ? -38.435 32.067  18.803 1.00 25.04  ? 514  HIS B CB    1 ? 
ATOM   8129 C CG    . HIS B 1 535 ? -38.396 33.527  18.453 1.00 25.43  ? 514  HIS B CG    1 ? 
ATOM   8130 N ND1   . HIS B 1 535 ? -39.542 34.258  18.249 1.00 30.04  ? 514  HIS B ND1   1 ? 
ATOM   8131 C CD2   . HIS B 1 535 ? -37.393 34.393  18.255 1.00 31.43  ? 514  HIS B CD2   1 ? 
ATOM   8132 C CE1   . HIS B 1 535 ? -39.234 35.509  17.927 1.00 32.06  ? 514  HIS B CE1   1 ? 
ATOM   8133 N NE2   . HIS B 1 535 ? -37.923 35.613  17.930 1.00 30.90  ? 514  HIS B NE2   1 ? 
ATOM   8134 N N     . THR B 1 536 ? -38.470 29.629  21.073 1.00 20.97  ? 515  THR B N     1 ? 
ATOM   8135 C CA    . THR B 1 536 ? -38.264 28.332  21.724 1.00 21.41  ? 515  THR B CA    1 ? 
ATOM   8136 C C     . THR B 1 536 ? -38.678 27.099  20.914 1.00 20.66  ? 515  THR B C     1 ? 
ATOM   8137 O O     . THR B 1 536 ? -38.352 25.998  21.354 1.00 22.45  ? 515  THR B O     1 ? 
ATOM   8138 C CB    . THR B 1 536 ? -38.905 28.344  23.120 1.00 21.52  ? 515  THR B CB    1 ? 
ATOM   8139 O OG1   . THR B 1 536 ? -40.201 28.946  23.005 1.00 21.12  ? 515  THR B OG1   1 ? 
ATOM   8140 C CG2   . THR B 1 536 ? -37.997 29.123  24.069 1.00 21.07  ? 515  THR B CG2   1 ? 
ATOM   8141 N N     . MET B 1 537 ? -39.379 27.235  19.775 1.00 21.70  ? 516  MET B N     1 ? 
ATOM   8142 C CA    . MET B 1 537 ? -39.781 26.063  19.000 1.00 21.37  ? 516  MET B CA    1 ? 
ATOM   8143 C C     . MET B 1 537 ? -38.555 25.222  18.611 1.00 21.17  ? 516  MET B C     1 ? 
ATOM   8144 O O     . MET B 1 537 ? -38.530 23.990  18.781 1.00 18.93  ? 516  MET B O     1 ? 
ATOM   8145 C CB    . MET B 1 537 ? -40.608 26.450  17.763 1.00 20.30  ? 516  MET B CB    1 ? 
ATOM   8146 C CG    . MET B 1 537 ? -41.019 25.263  16.878 1.00 20.90  ? 516  MET B CG    1 ? 
ATOM   8147 S SD    . MET B 1 537 ? -42.217 25.641  15.572 1.00 22.77  ? 516  MET B SD    1 ? 
ATOM   8148 C CE    . MET B 1 537 ? -41.524 27.127  14.839 1.00 23.92  ? 516  MET B CE    1 ? 
ATOM   8149 N N     . ALA B 1 538 ? -37.517 25.888  18.084 1.00 21.47  ? 517  ALA B N     1 ? 
ATOM   8150 C CA    . ALA B 1 538 ? -36.364 25.192  17.539 1.00 21.46  ? 517  ALA B CA    1 ? 
ATOM   8151 C C     . ALA B 1 538 ? -35.608 24.394  18.606 1.00 23.28  ? 517  ALA B C     1 ? 
ATOM   8152 O O     . ALA B 1 538 ? -35.373 23.181  18.429 1.00 24.03  ? 517  ALA B O     1 ? 
ATOM   8153 C CB    . ALA B 1 538 ? -35.449 26.177  16.812 1.00 26.40  ? 517  ALA B CB    1 ? 
ATOM   8154 N N     . PRO B 1 539 ? -35.186 24.997  19.745 1.00 21.61  ? 518  PRO B N     1 ? 
ATOM   8155 C CA    . PRO B 1 539 ? -34.583 24.204  20.808 1.00 21.09  ? 518  PRO B CA    1 ? 
ATOM   8156 C C     . PRO B 1 539 ? -35.500 23.087  21.328 1.00 20.23  ? 518  PRO B C     1 ? 
ATOM   8157 O O     . PRO B 1 539 ? -35.009 22.050  21.729 1.00 21.09  ? 518  PRO B O     1 ? 
ATOM   8158 C CB    . PRO B 1 539 ? -34.188 25.217  21.886 1.00 21.62  ? 518  PRO B CB    1 ? 
ATOM   8159 C CG    . PRO B 1 539 ? -34.975 26.465  21.553 1.00 21.66  ? 518  PRO B CG    1 ? 
ATOM   8160 C CD    . PRO B 1 539 ? -35.186 26.446  20.038 1.00 23.12  ? 518  PRO B CD    1 ? 
ATOM   8161 N N     . VAL B 1 540 ? -36.821 23.251  21.265 1.00 19.83  ? 519  VAL B N     1 ? 
ATOM   8162 C CA    . VAL B 1 540 ? -37.726 22.196  21.724 1.00 20.50  ? 519  VAL B CA    1 ? 
ATOM   8163 C C     . VAL B 1 540 ? -37.649 20.973  20.805 1.00 21.39  ? 519  VAL B C     1 ? 
ATOM   8164 O O     . VAL B 1 540 ? -37.648 19.847  21.306 1.00 22.60  ? 519  VAL B O     1 ? 
ATOM   8165 C CB    . VAL B 1 540 ? -39.178 22.667  21.908 1.00 22.37  ? 519  VAL B CB    1 ? 
ATOM   8166 C CG1   . VAL B 1 540 ? -40.122 21.488  22.165 1.00 21.77  ? 519  VAL B CG1   1 ? 
ATOM   8167 C CG2   . VAL B 1 540 ? -39.298 23.683  23.047 1.00 22.81  ? 519  VAL B CG2   1 ? 
ATOM   8168 N N     . VAL B 1 541 ? -37.596 21.192  19.480 1.00 21.17  ? 520  VAL B N     1 ? 
ATOM   8169 C CA    . VAL B 1 541 ? -37.405 20.093  18.541 1.00 24.49  ? 520  VAL B CA    1 ? 
ATOM   8170 C C     . VAL B 1 541 ? -36.045 19.421  18.782 1.00 24.95  ? 520  VAL B C     1 ? 
ATOM   8171 O O     . VAL B 1 541 ? -35.944 18.194  18.770 1.00 24.71  ? 520  VAL B O     1 ? 
ATOM   8172 C CB    . VAL B 1 541 ? -37.568 20.530  17.077 1.00 22.97  ? 520  VAL B CB    1 ? 
ATOM   8173 C CG1   . VAL B 1 541 ? -37.366 19.358  16.104 1.00 25.15  ? 520  VAL B CG1   1 ? 
ATOM   8174 C CG2   . VAL B 1 541 ? -38.920 21.185  16.850 1.00 21.87  ? 520  VAL B CG2   1 ? 
ATOM   8175 N N     . TYR B 1 542 ? -35.003 20.229  19.032 1.00 26.16  ? 521  TYR B N     1 ? 
ATOM   8176 C CA    . TYR B 1 542 ? -33.712 19.717  19.463 1.00 24.17  ? 521  TYR B CA    1 ? 
ATOM   8177 C C     . TYR B 1 542 ? -33.863 18.798  20.674 1.00 24.59  ? 521  TYR B C     1 ? 
ATOM   8178 O O     . TYR B 1 542 ? -33.262 17.716  20.720 1.00 22.70  ? 521  TYR B O     1 ? 
ATOM   8179 C CB    . TYR B 1 542 ? -32.760 20.900  19.688 1.00 24.85  ? 521  TYR B CB    1 ? 
ATOM   8180 C CG    . TYR B 1 542 ? -31.531 20.656  20.564 1.00 26.43  ? 521  TYR B CG    1 ? 
ATOM   8181 C CD1   . TYR B 1 542 ? -30.475 19.846  20.155 1.00 27.95  ? 521  TYR B CD1   1 ? 
ATOM   8182 C CD2   . TYR B 1 542 ? -31.391 21.314  21.783 1.00 25.36  ? 521  TYR B CD2   1 ? 
ATOM   8183 C CE1   . TYR B 1 542 ? -29.360 19.648  20.955 1.00 26.44  ? 521  TYR B CE1   1 ? 
ATOM   8184 C CE2   . TYR B 1 542 ? -30.280 21.128  22.579 1.00 26.41  ? 521  TYR B CE2   1 ? 
ATOM   8185 C CZ    . TYR B 1 542 ? -29.250 20.301  22.163 1.00 25.94  ? 521  TYR B CZ    1 ? 
ATOM   8186 O OH    . TYR B 1 542 ? -28.156 20.184  22.989 1.00 23.56  ? 521  TYR B OH    1 ? 
ATOM   8187 N N     . VAL B 1 543 ? -34.626 19.239  21.691 1.00 22.64  ? 522  VAL B N     1 ? 
ATOM   8188 C CA    . VAL B 1 543 ? -34.873 18.403  22.860 1.00 21.87  ? 522  VAL B CA    1 ? 
ATOM   8189 C C     . VAL B 1 543 ? -35.484 17.056  22.449 1.00 22.69  ? 522  VAL B C     1 ? 
ATOM   8190 O O     . VAL B 1 543 ? -35.119 16.010  22.995 1.00 24.84  ? 522  VAL B O     1 ? 
ATOM   8191 C CB    . VAL B 1 543 ? -35.749 19.148  23.888 1.00 23.80  ? 522  VAL B CB    1 ? 
ATOM   8192 C CG1   . VAL B 1 543 ? -36.306 18.229  24.964 1.00 25.13  ? 522  VAL B CG1   1 ? 
ATOM   8193 C CG2   . VAL B 1 543 ? -35.003 20.288  24.554 1.00 24.79  ? 522  VAL B CG2   1 ? 
ATOM   8194 N N     . GLY B 1 544 ? -36.430 17.077  21.510 1.00 22.24  ? 523  GLY B N     1 ? 
ATOM   8195 C CA    . GLY B 1 544 ? -37.096 15.853  21.073 1.00 22.60  ? 523  GLY B CA    1 ? 
ATOM   8196 C C     . GLY B 1 544 ? -36.100 14.883  20.426 1.00 23.95  ? 523  GLY B C     1 ? 
ATOM   8197 O O     . GLY B 1 544 ? -36.125 13.690  20.715 1.00 20.42  ? 523  GLY B O     1 ? 
ATOM   8198 N N     . GLU B 1 545 ? -35.222 15.401  19.548 1.00 27.19  ? 524  GLU B N     1 ? 
ATOM   8199 C CA    . GLU B 1 545 ? -34.225 14.579  18.868 1.00 27.73  ? 524  GLU B CA    1 ? 
ATOM   8200 C C     . GLU B 1 545 ? -33.212 14.037  19.880 1.00 28.02  ? 524  GLU B C     1 ? 
ATOM   8201 O O     . GLU B 1 545 ? -32.821 12.867  19.834 1.00 30.80  ? 524  GLU B O     1 ? 
ATOM   8202 C CB    . GLU B 1 545 ? -33.541 15.386  17.761 1.00 29.49  ? 524  GLU B CB    1 ? 
ATOM   8203 C CG    . GLU B 1 545 ? -34.370 15.634  16.504 1.00 29.04  ? 524  GLU B CG    1 ? 
ATOM   8204 C CD    . GLU B 1 545 ? -34.614 14.409  15.628 1.00 27.72  ? 524  GLU B CD    1 ? 
ATOM   8205 O OE1   . GLU B 1 545 ? -35.005 14.655  14.478 1.00 25.91  ? 524  GLU B OE1   1 ? 
ATOM   8206 O OE2   . GLU B 1 545 ? -34.474 13.255  16.077 1.00 28.68  ? 524  GLU B OE2   1 ? 
ATOM   8207 N N     . MET B 1 546 ? -32.830 14.872  20.847 1.00 25.75  ? 525  MET B N     1 ? 
ATOM   8208 C CA    . MET B 1 546 ? -31.887 14.474  21.875 1.00 24.96  ? 525  MET B CA    1 ? 
ATOM   8209 C C     . MET B 1 546 ? -32.478 13.394  22.791 1.00 27.96  ? 525  MET B C     1 ? 
ATOM   8210 O O     . MET B 1 546 ? -31.801 12.414  23.108 1.00 26.15  ? 525  MET B O     1 ? 
ATOM   8211 C CB    . MET B 1 546 ? -31.432 15.697  22.683 1.00 26.04  ? 525  MET B CB    1 ? 
ATOM   8212 C CG    . MET B 1 546 ? -30.532 16.661  21.900 1.00 29.93  ? 525  MET B CG    1 ? 
ATOM   8213 S SD    . MET B 1 546 ? -28.863 16.003  21.656 1.00 30.72  ? 525  MET B SD    1 ? 
ATOM   8214 C CE    . MET B 1 546 ? -28.295 16.329  23.340 1.00 30.67  ? 525  MET B CE    1 ? 
ATOM   8215 N N     . ALA B 1 547 ? -33.724 13.578  23.239 1.00 25.33  ? 526  ALA B N     1 ? 
ATOM   8216 C CA    . ALA B 1 547 ? -34.407 12.578  24.054 1.00 27.27  ? 526  ALA B CA    1 ? 
ATOM   8217 C C     . ALA B 1 547 ? -34.455 11.231  23.337 1.00 25.70  ? 526  ALA B C     1 ? 
ATOM   8218 O O     . ALA B 1 547 ? -34.283 10.195  23.952 1.00 31.18  ? 526  ALA B O     1 ? 
ATOM   8219 C CB    . ALA B 1 547 ? -35.812 13.030  24.396 1.00 25.78  ? 526  ALA B CB    1 ? 
ATOM   8220 N N     . SER B 1 548 ? -34.811 11.261  22.061 1.00 26.37  ? 527  SER B N     1 ? 
ATOM   8221 C CA    . SER B 1 548 ? -34.932 10.061  21.248 1.00 28.12  ? 527  SER B CA    1 ? 
ATOM   8222 C C     . SER B 1 548 ? -33.610 9.283   21.236 1.00 28.63  ? 527  SER B C     1 ? 
ATOM   8223 O O     . SER B 1 548 ? -33.596 8.083   21.520 1.00 29.46  ? 527  SER B O     1 ? 
ATOM   8224 C CB    . SER B 1 548 ? -35.326 10.419  19.868 1.00 26.78  ? 527  SER B CB    1 ? 
ATOM   8225 O OG    . SER B 1 548 ? -36.570 11.109  19.824 1.00 26.38  ? 527  SER B OG    1 ? 
ATOM   8226 N N     . GLU B 1 549 ? -32.519 9.988   20.921 1.00 29.67  ? 528  GLU B N     1 ? 
ATOM   8227 C CA    . GLU B 1 549 ? -31.160 9.443   20.952 1.00 34.51  ? 528  GLU B CA    1 ? 
ATOM   8228 C C     . GLU B 1 549 ? -30.812 8.832   22.307 1.00 30.06  ? 528  GLU B C     1 ? 
ATOM   8229 O O     . GLU B 1 549 ? -30.259 7.739   22.400 1.00 30.60  ? 528  GLU B O     1 ? 
ATOM   8230 C CB    . GLU B 1 549 ? -30.096 10.527  20.777 1.00 37.60  ? 528  GLU B CB    1 ? 
ATOM   8231 C CG    . GLU B 1 549 ? -29.302 10.405  19.484 1.00 48.19  ? 528  GLU B CG    1 ? 
ATOM   8232 C CD    . GLU B 1 549 ? -27.899 11.012  19.413 1.00 41.99  ? 528  GLU B CD    1 ? 
ATOM   8233 O OE1   . GLU B 1 549 ? -27.460 11.062  18.260 1.00 49.01  ? 528  GLU B OE1   1 ? 
ATOM   8234 O OE2   . GLU B 1 549 ? -27.265 11.443  20.396 1.00 40.73  ? 528  GLU B OE2   1 ? 
ATOM   8235 N N     . ILE B 1 550 ? -31.089 9.586   23.365 1.00 32.53  ? 529  ILE B N     1 ? 
ATOM   8236 C CA    . ILE B 1 550 ? -30.754 9.180   24.718 1.00 29.85  ? 529  ILE B CA    1 ? 
ATOM   8237 C C     . ILE B 1 550 ? -31.507 7.903   25.066 1.00 36.08  ? 529  ILE B C     1 ? 
ATOM   8238 O O     . ILE B 1 550 ? -30.926 6.951   25.579 1.00 38.95  ? 529  ILE B O     1 ? 
ATOM   8239 C CB    . ILE B 1 550 ? -31.038 10.328  25.693 1.00 28.88  ? 529  ILE B CB    1 ? 
ATOM   8240 C CG1   . ILE B 1 550 ? -29.970 11.422  25.572 1.00 29.96  ? 529  ILE B CG1   1 ? 
ATOM   8241 C CG2   . ILE B 1 550 ? -31.148 9.817   27.124 1.00 31.81  ? 529  ILE B CG2   1 ? 
ATOM   8242 C CD1   . ILE B 1 550 ? -30.406 12.786  26.085 1.00 30.51  ? 529  ILE B CD1   1 ? 
ATOM   8243 N N     . ILE B 1 551 ? -32.801 7.874   24.771 1.00 35.56  ? 530  ILE B N     1 ? 
ATOM   8244 C CA    . ILE B 1 551 ? -33.608 6.724   25.138 1.00 36.17  ? 530  ILE B CA    1 ? 
ATOM   8245 C C     . ILE B 1 551 ? -33.175 5.491   24.338 1.00 36.23  ? 530  ILE B C     1 ? 
ATOM   8246 O O     . ILE B 1 551 ? -33.044 4.423   24.917 1.00 37.57  ? 530  ILE B O     1 ? 
ATOM   8247 C CB    . ILE B 1 551 ? -35.103 7.026   24.965 1.00 33.00  ? 530  ILE B CB    1 ? 
ATOM   8248 C CG1   . ILE B 1 551 ? -35.568 8.035   26.008 1.00 32.83  ? 530  ILE B CG1   1 ? 
ATOM   8249 C CG2   . ILE B 1 551 ? -35.925 5.738   25.021 1.00 34.86  ? 530  ILE B CG2   1 ? 
ATOM   8250 C CD1   . ILE B 1 551 ? -36.828 8.762   25.627 1.00 35.40  ? 530  ILE B CD1   1 ? 
ATOM   8251 N N     . ILE B 1 552 ? -32.983 5.648   23.024 1.00 37.50  ? 531  ILE B N     1 ? 
ATOM   8252 C CA    . ILE B 1 552 ? -32.635 4.541   22.159 1.00 37.96  ? 531  ILE B CA    1 ? 
ATOM   8253 C C     . ILE B 1 552 ? -31.324 3.918   22.634 1.00 45.10  ? 531  ILE B C     1 ? 
ATOM   8254 O O     . ILE B 1 552 ? -31.190 2.697   22.598 1.00 40.30  ? 531  ILE B O     1 ? 
ATOM   8255 C CB    . ILE B 1 552 ? -32.590 4.998   20.692 1.00 40.31  ? 531  ILE B CB    1 ? 
ATOM   8256 C CG1   . ILE B 1 552 ? -34.010 5.174   20.156 1.00 40.94  ? 531  ILE B CG1   1 ? 
ATOM   8257 C CG2   . ILE B 1 552 ? -31.764 4.046   19.814 1.00 41.29  ? 531  ILE B CG2   1 ? 
ATOM   8258 C CD1   . ILE B 1 552 ? -34.099 5.976   18.872 1.00 40.00  ? 531  ILE B CD1   1 ? 
ATOM   8259 N N     . ASN B 1 553 ? -30.382 4.757   23.106 1.00 47.81  ? 532  ASN B N     1 ? 
ATOM   8260 C CA    . ASN B 1 553 ? -29.047 4.313   23.496 1.00 53.88  ? 532  ASN B CA    1 ? 
ATOM   8261 C C     . ASN B 1 553 ? -29.031 3.708   24.898 1.00 57.87  ? 532  ASN B C     1 ? 
ATOM   8262 O O     . ASN B 1 553 ? -28.022 3.142   25.298 1.00 73.80  ? 532  ASN B O     1 ? 
ATOM   8263 C CB    . ASN B 1 553 ? -28.021 5.437   23.387 1.00 53.89  ? 532  ASN B CB    1 ? 
ATOM   8264 C CG    . ASN B 1 553 ? -27.661 5.743   21.949 1.00 57.46  ? 532  ASN B CG    1 ? 
ATOM   8265 O OD1   . ASN B 1 553 ? -28.085 5.033   21.028 1.00 62.47  ? 532  ASN B OD1   1 ? 
ATOM   8266 N ND2   . ASN B 1 553 ? -26.882 6.789   21.726 1.00 59.74  ? 532  ASN B ND2   1 ? 
ATOM   8267 N N     . ASP B 1 554 ? -30.121 3.853   25.655 1.00 64.15  ? 533  ASP B N     1 ? 
ATOM   8268 C CA    . ASP B 1 554 ? -30.306 3.123   26.902 1.00 68.30  ? 533  ASP B CA    1 ? 
ATOM   8269 C C     . ASP B 1 554 ? -30.719 1.679   26.613 1.00 74.30  ? 533  ASP B C     1 ? 
ATOM   8270 O O     . ASP B 1 554 ? -30.280 0.764   27.308 1.00 65.63  ? 533  ASP B O     1 ? 
ATOM   8271 C CB    . ASP B 1 554 ? -31.326 3.796   27.810 1.00 69.11  ? 533  ASP B CB    1 ? 
ATOM   8272 C CG    . ASP B 1 554 ? -30.754 4.610   28.959 1.00 74.59  ? 533  ASP B CG    1 ? 
ATOM   8273 O OD1   . ASP B 1 554 ? -30.231 3.975   29.894 1.00 80.37  ? 533  ASP B OD1   1 ? 
ATOM   8274 O OD2   . ASP B 1 554 ? -30.843 5.869   28.914 1.00 76.44  ? 533  ASP B OD2   1 ? 
ATOM   8275 N N     . ASN B 1 555 ? -31.570 1.494   25.589 1.00 83.31  ? 534  ASN B N     1 ? 
ATOM   8276 C CA    . ASN B 1 555 ? -32.201 0.217   25.282 1.00 84.84  ? 534  ASN B CA    1 ? 
ATOM   8277 C C     . ASN B 1 555 ? -31.437 -0.488  24.153 1.00 80.56  ? 534  ASN B C     1 ? 
ATOM   8278 O O     . ASN B 1 555 ? -32.080 -0.812  23.135 1.00 78.91  ? 534  ASN B O     1 ? 
ATOM   8279 C CB    . ASN B 1 555 ? -33.668 0.415   24.913 1.00 86.67  ? 534  ASN B CB    1 ? 
ATOM   8280 C CG    . ASN B 1 555 ? -34.426 1.173   25.979 1.00 91.46  ? 534  ASN B CG    1 ? 
ATOM   8281 O OD1   . ASN B 1 555 ? -34.880 0.576   26.961 1.00 108.88 ? 534  ASN B OD1   1 ? 
ATOM   8282 N ND2   . ASN B 1 555 ? -34.603 2.474   25.794 1.00 79.69  ? 534  ASN B ND2   1 ? 
ATOM   8283 O OXT   . ASN B 1 555 ? -30.220 -0.692  24.331 1.00 84.16  ? 534  ASN B OXT   1 ? 
HETATM 8284 C C1    . 1BO C 2 .   ? 12.936  0.039   37.829 1.00 23.94  ? 601  1BO A C1    1 ? 
HETATM 8285 C C2    . 1BO C 2 .   ? 12.071  0.557   36.692 1.00 29.32  ? 601  1BO A C2    1 ? 
HETATM 8286 C C3    . 1BO C 2 .   ? 10.761  -0.021  36.238 1.00 21.76  ? 601  1BO A C3    1 ? 
HETATM 8287 C C4    . 1BO C 2 .   ? 10.174  -1.191  37.038 1.00 31.32  ? 601  1BO A C4    1 ? 
HETATM 8288 O OH    . 1BO C 2 .   ? 8.850   -1.678  36.673 1.00 20.11  ? 601  1BO A OH    1 ? 
HETATM 8289 C C1    . 1BO D 2 .   ? 19.481  13.075  38.437 1.00 25.00  ? 602  1BO A C1    1 ? 
HETATM 8290 C C2    . 1BO D 2 .   ? 19.493  14.525  38.620 1.00 26.10  ? 602  1BO A C2    1 ? 
HETATM 8291 C C3    . 1BO D 2 .   ? 18.102  15.141  38.580 1.00 31.51  ? 602  1BO A C3    1 ? 
HETATM 8292 C C4    . 1BO D 2 .   ? 18.059  16.580  39.054 1.00 35.29  ? 602  1BO A C4    1 ? 
HETATM 8293 O OH    . 1BO D 2 .   ? 18.540  17.548  38.109 1.00 35.32  ? 602  1BO A OH    1 ? 
HETATM 8294 P PA    . FAD E 3 .   ? 3.614   6.629   22.803 1.00 19.74  ? 603  FAD A PA    1 ? 
HETATM 8295 O O1A   . FAD E 3 .   ? 3.388   6.325   21.365 1.00 17.63  ? 603  FAD A O1A   1 ? 
HETATM 8296 O O2A   . FAD E 3 .   ? 4.509   5.791   23.654 1.00 20.29  ? 603  FAD A O2A   1 ? 
HETATM 8297 O O5B   . FAD E 3 .   ? 4.025   8.190   22.799 1.00 17.39  ? 603  FAD A O5B   1 ? 
HETATM 8298 C C5B   . FAD E 3 .   ? 4.605   8.775   23.964 1.00 18.03  ? 603  FAD A C5B   1 ? 
HETATM 8299 C C4B   . FAD E 3 .   ? 5.695   9.714   23.520 1.00 16.97  ? 603  FAD A C4B   1 ? 
HETATM 8300 O O4B   . FAD E 3 .   ? 6.064   10.602  24.600 1.00 19.12  ? 603  FAD A O4B   1 ? 
HETATM 8301 C C3B   . FAD E 3 .   ? 6.982   9.041   23.028 1.00 17.53  ? 603  FAD A C3B   1 ? 
HETATM 8302 O O3B   . FAD E 3 .   ? 7.336   9.520   21.729 1.00 17.85  ? 603  FAD A O3B   1 ? 
HETATM 8303 C C2B   . FAD E 3 .   ? 7.936   9.301   24.187 1.00 19.42  ? 603  FAD A C2B   1 ? 
HETATM 8304 O O2B   . FAD E 3 .   ? 9.295   9.320   23.840 1.00 20.30  ? 603  FAD A O2B   1 ? 
HETATM 8305 C C1B   . FAD E 3 .   ? 7.475   10.685  24.646 1.00 19.13  ? 603  FAD A C1B   1 ? 
HETATM 8306 N N9A   . FAD E 3 .   ? 7.829   11.009  26.018 1.00 17.54  ? 603  FAD A N9A   1 ? 
HETATM 8307 C C8A   . FAD E 3 .   ? 7.525   10.254  27.127 1.00 19.59  ? 603  FAD A C8A   1 ? 
HETATM 8308 N N7A   . FAD E 3 .   ? 7.971   10.762  28.252 1.00 17.06  ? 603  FAD A N7A   1 ? 
HETATM 8309 C C5A   . FAD E 3 .   ? 8.532   11.964  27.861 1.00 17.58  ? 603  FAD A C5A   1 ? 
HETATM 8310 C C6A   . FAD E 3 .   ? 9.129   12.987  28.610 1.00 17.13  ? 603  FAD A C6A   1 ? 
HETATM 8311 N N6A   . FAD E 3 .   ? 9.207   12.977  29.946 1.00 17.41  ? 603  FAD A N6A   1 ? 
HETATM 8312 N N1A   . FAD E 3 .   ? 9.599   14.052  27.926 1.00 18.10  ? 603  FAD A N1A   1 ? 
HETATM 8313 C C2A   . FAD E 3 .   ? 9.447   14.088  26.594 1.00 20.21  ? 603  FAD A C2A   1 ? 
HETATM 8314 N N3A   . FAD E 3 .   ? 8.902   13.186  25.775 1.00 18.12  ? 603  FAD A N3A   1 ? 
HETATM 8315 C C4A   . FAD E 3 .   ? 8.449   12.134  26.487 1.00 19.29  ? 603  FAD A C4A   1 ? 
HETATM 8316 N N1    . FAD E 3 .   ? -0.645  -1.121  18.776 1.00 18.35  ? 603  FAD A N1    1 ? 
HETATM 8317 C C2    . FAD E 3 .   ? -1.325  -1.396  17.625 1.00 20.86  ? 603  FAD A C2    1 ? 
HETATM 8318 O O2    . FAD E 3 .   ? -2.444  -0.908  17.392 1.00 20.34  ? 603  FAD A O2    1 ? 
HETATM 8319 N N3    . FAD E 3 .   ? -0.738  -2.262  16.704 1.00 21.71  ? 603  FAD A N3    1 ? 
HETATM 8320 C C4    . FAD E 3 .   ? 0.441   -2.988  16.881 1.00 20.53  ? 603  FAD A C4    1 ? 
HETATM 8321 O O4    . FAD E 3 .   ? 0.942   -3.600  15.947 1.00 19.80  ? 603  FAD A O4    1 ? 
HETATM 8322 C C4X   . FAD E 3 .   ? 1.151   -2.651  18.082 1.00 18.65  ? 603  FAD A C4X   1 ? 
HETATM 8323 N N5    . FAD E 3 .   ? 2.305   -3.264  18.337 1.00 19.98  ? 603  FAD A N5    1 ? 
HETATM 8324 C C5X   . FAD E 3 .   ? 3.045   -2.788  19.396 1.00 18.91  ? 603  FAD A C5X   1 ? 
HETATM 8325 C C6    . FAD E 3 .   ? 4.350   -3.278  19.585 1.00 20.37  ? 603  FAD A C6    1 ? 
HETATM 8326 C C7    . FAD E 3 .   ? 5.195   -2.754  20.543 1.00 20.83  ? 603  FAD A C7    1 ? 
HETATM 8327 C C7M   . FAD E 3 .   ? 6.588   -3.317  20.695 1.00 21.05  ? 603  FAD A C7M   1 ? 
HETATM 8328 C C8    . FAD E 3 .   ? 4.743   -1.646  21.320 1.00 21.09  ? 603  FAD A C8    1 ? 
HETATM 8329 C C8M   . FAD E 3 .   ? 5.619   -1.071  22.396 1.00 24.95  ? 603  FAD A C8M   1 ? 
HETATM 8330 C C9    . FAD E 3 .   ? 3.412   -1.271  21.257 1.00 19.59  ? 603  FAD A C9    1 ? 
HETATM 8331 C C9A   . FAD E 3 .   ? 2.570   -1.766  20.245 1.00 18.46  ? 603  FAD A C9A   1 ? 
HETATM 8332 N N10   . FAD E 3 .   ? 1.268   -1.314  20.066 1.00 18.60  ? 603  FAD A N10   1 ? 
HETATM 8333 C C10   . FAD E 3 .   ? 0.534   -1.686  18.957 1.00 18.51  ? 603  FAD A C10   1 ? 
HETATM 8334 C "C1'" . FAD E 3 .   ? 0.677   -0.304  20.982 1.00 17.56  ? 603  FAD A "C1'" 1 ? 
HETATM 8335 C "C2'" . FAD E 3 .   ? 0.601   1.105   20.445 1.00 19.11  ? 603  FAD A "C2'" 1 ? 
HETATM 8336 O "O2'" . FAD E 3 .   ? 1.743   1.266   19.611 1.00 18.00  ? 603  FAD A "O2'" 1 ? 
HETATM 8337 C "C3'" . FAD E 3 .   ? 0.503   2.093   21.606 1.00 18.46  ? 603  FAD A "C3'" 1 ? 
HETATM 8338 O "O3'" . FAD E 3 .   ? -0.590  1.691   22.441 1.00 19.34  ? 603  FAD A "O3'" 1 ? 
HETATM 8339 C "C4'" . FAD E 3 .   ? 0.350   3.552   21.143 1.00 19.77  ? 603  FAD A "C4'" 1 ? 
HETATM 8340 O "O4'" . FAD E 3 .   ? 1.282   3.839   20.094 1.00 17.27  ? 603  FAD A "O4'" 1 ? 
HETATM 8341 C "C5'" . FAD E 3 .   ? 0.629   4.444   22.342 1.00 18.88  ? 603  FAD A "C5'" 1 ? 
HETATM 8342 O "O5'" . FAD E 3 .   ? 0.387   5.782   21.919 1.00 19.17  ? 603  FAD A "O5'" 1 ? 
HETATM 8343 P P     . FAD E 3 .   ? 0.657   6.986   22.927 1.00 20.21  ? 603  FAD A P     1 ? 
HETATM 8344 O O1P   . FAD E 3 .   ? 0.665   8.277   22.199 1.00 20.55  ? 603  FAD A O1P   1 ? 
HETATM 8345 O O2P   . FAD E 3 .   ? -0.154  6.798   24.161 1.00 19.77  ? 603  FAD A O2P   1 ? 
HETATM 8346 O O3P   . FAD E 3 .   ? 2.166   6.742   23.448 1.00 19.68  ? 603  FAD A O3P   1 ? 
HETATM 8347 O O1    . HEZ F 4 .   ? -0.117  -5.298  18.827 1.00 36.28  ? 604  HEZ A O1    1 ? 
HETATM 8348 C C1    . HEZ F 4 .   ? 0.913   -6.317  18.996 1.00 40.83  ? 604  HEZ A C1    1 ? 
HETATM 8349 C C2    . HEZ F 4 .   ? 1.273   -7.097  17.719 1.00 48.48  ? 604  HEZ A C2    1 ? 
HETATM 8350 C C3    . HEZ F 4 .   ? 0.616   -8.477  17.578 1.00 54.48  ? 604  HEZ A C3    1 ? 
HETATM 8351 C C4    . HEZ F 4 .   ? 1.466   -9.653  18.068 1.00 56.33  ? 604  HEZ A C4    1 ? 
HETATM 8352 C C5    . HEZ F 4 .   ? 1.297   -10.915 17.232 1.00 58.80  ? 604  HEZ A C5    1 ? 
HETATM 8353 C C6    . HEZ F 4 .   ? 1.956   -12.152 17.818 1.00 58.66  ? 604  HEZ A C6    1 ? 
HETATM 8354 O O6    . HEZ F 4 .   ? 2.464   -13.029 16.815 1.00 56.57  ? 604  HEZ A O6    1 ? 
HETATM 8355 P PA    . FAD G 3 .   ? -46.545 22.298  23.360 1.00 19.77  ? 601  FAD B PA    1 ? 
HETATM 8356 O O1A   . FAD G 3 .   ? -46.231 22.532  21.924 1.00 17.59  ? 601  FAD B O1A   1 ? 
HETATM 8357 O O2A   . FAD G 3 .   ? -47.534 23.221  23.985 1.00 18.69  ? 601  FAD B O2A   1 ? 
HETATM 8358 O O5B   . FAD G 3 .   ? -47.037 20.774  23.369 1.00 19.15  ? 601  FAD B O5B   1 ? 
HETATM 8359 C C5B   . FAD G 3 .   ? -47.626 20.188  24.578 1.00 18.72  ? 601  FAD B C5B   1 ? 
HETATM 8360 C C4B   . FAD G 3 .   ? -48.729 19.283  24.082 1.00 17.77  ? 601  FAD B C4B   1 ? 
HETATM 8361 O O4B   . FAD G 3 .   ? -49.218 18.484  25.172 1.00 17.37  ? 601  FAD B O4B   1 ? 
HETATM 8362 C C3B   . FAD G 3 .   ? -49.950 20.003  23.500 1.00 18.35  ? 601  FAD B C3B   1 ? 
HETATM 8363 O O3B   . FAD G 3 .   ? -50.306 19.469  22.226 1.00 17.25  ? 601  FAD B O3B   1 ? 
HETATM 8364 C C2B   . FAD G 3 .   ? -51.005 19.853  24.602 1.00 17.85  ? 601  FAD B C2B   1 ? 
HETATM 8365 O O2B   . FAD G 3 .   ? -52.350 19.827  24.152 1.00 19.81  ? 601  FAD B O2B   1 ? 
HETATM 8366 C C1B   . FAD G 3 .   ? -50.639 18.504  25.207 1.00 17.39  ? 601  FAD B C1B   1 ? 
HETATM 8367 N N9A   . FAD G 3 .   ? -51.058 18.282  26.601 1.00 18.25  ? 601  FAD B N9A   1 ? 
HETATM 8368 C C8A   . FAD G 3 .   ? -50.843 19.119  27.678 1.00 18.58  ? 601  FAD B C8A   1 ? 
HETATM 8369 N N7A   . FAD G 3 .   ? -51.316 18.667  28.815 1.00 17.19  ? 601  FAD B N7A   1 ? 
HETATM 8370 C C5A   . FAD G 3 .   ? -51.888 17.448  28.458 1.00 18.51  ? 601  FAD B C5A   1 ? 
HETATM 8371 C C6A   . FAD G 3 .   ? -52.569 16.483  29.225 1.00 18.09  ? 601  FAD B C6A   1 ? 
HETATM 8372 N N6A   . FAD G 3 .   ? -52.776 16.616  30.541 1.00 20.24  ? 601  FAD B N6A   1 ? 
HETATM 8373 N N1A   . FAD G 3 .   ? -53.017 15.367  28.585 1.00 17.68  ? 601  FAD B N1A   1 ? 
HETATM 8374 C C2A   . FAD G 3 .   ? -52.789 15.259  27.261 1.00 18.84  ? 601  FAD B C2A   1 ? 
HETATM 8375 N N3A   . FAD G 3 .   ? -52.161 16.111  26.438 1.00 18.60  ? 601  FAD B N3A   1 ? 
HETATM 8376 C C4A   . FAD G 3 .   ? -51.727 17.197  27.105 1.00 17.86  ? 601  FAD B C4A   1 ? 
HETATM 8377 N N1    . FAD G 3 .   ? -41.764 29.687  19.141 1.00 18.20  ? 601  FAD B N1    1 ? 
HETATM 8378 C C2    . FAD G 3 .   ? -40.997 29.843  18.026 1.00 21.00  ? 601  FAD B C2    1 ? 
HETATM 8379 O O2    . FAD G 3 .   ? -39.896 29.306  17.930 1.00 21.59  ? 601  FAD B O2    1 ? 
HETATM 8380 N N3    . FAD G 3 .   ? -41.483 30.620  16.983 1.00 20.96  ? 601  FAD B N3    1 ? 
HETATM 8381 C C4    . FAD G 3 .   ? -42.622 31.411  17.028 1.00 22.41  ? 601  FAD B C4    1 ? 
HETATM 8382 O O4    . FAD G 3 .   ? -43.009 31.982  16.025 1.00 23.09  ? 601  FAD B O4    1 ? 
HETATM 8383 C C4X   . FAD G 3 .   ? -43.442 31.190  18.186 1.00 21.31  ? 601  FAD B C4X   1 ? 
HETATM 8384 N N5    . FAD G 3 .   ? -44.603 31.835  18.281 1.00 22.00  ? 601  FAD B N5    1 ? 
HETATM 8385 C C5X   . FAD G 3 .   ? -45.453 31.438  19.295 1.00 22.84  ? 601  FAD B C5X   1 ? 
HETATM 8386 C C6    . FAD G 3 .   ? -46.763 31.964  19.325 1.00 23.52  ? 601  FAD B C6    1 ? 
HETATM 8387 C C7    . FAD G 3 .   ? -47.708 31.497  20.224 1.00 23.67  ? 601  FAD B C7    1 ? 
HETATM 8388 C C7M   . FAD G 3 .   ? -49.104 32.053  20.197 1.00 22.86  ? 601  FAD B C7M   1 ? 
HETATM 8389 C C8    . FAD G 3 .   ? -47.346 30.485  21.145 1.00 22.06  ? 601  FAD B C8    1 ? 
HETATM 8390 C C8M   . FAD G 3 .   ? -48.345 29.978  22.152 1.00 22.62  ? 601  FAD B C8M   1 ? 
HETATM 8391 C C9    . FAD G 3 .   ? -46.024 30.095  21.236 1.00 21.97  ? 601  FAD B C9    1 ? 
HETATM 8392 C C9A   . FAD G 3 .   ? -45.074 30.484  20.270 1.00 21.29  ? 601  FAD B C9A   1 ? 
HETATM 8393 N N10   . FAD G 3 .   ? -43.753 30.021  20.264 1.00 19.30  ? 601  FAD B N10   1 ? 
HETATM 8394 C C10   . FAD G 3 .   ? -42.926 30.296  19.186 1.00 20.15  ? 601  FAD B C10   1 ? 
HETATM 8395 C "C1'" . FAD G 3 .   ? -43.242 29.034  21.238 1.00 17.65  ? 601  FAD B "C1'" 1 ? 
HETATM 8396 C "C2'" . FAD G 3 .   ? -43.105 27.583  20.784 1.00 18.79  ? 601  FAD B "C2'" 1 ? 
HETATM 8397 O "O2'" . FAD G 3 .   ? -44.237 27.290  19.939 1.00 17.90  ? 601  FAD B "O2'" 1 ? 
HETATM 8398 C "C3'" . FAD G 3 .   ? -43.189 26.701  22.038 1.00 18.91  ? 601  FAD B "C3'" 1 ? 
HETATM 8399 O "O3'" . FAD G 3 .   ? -42.205 27.104  22.991 1.00 19.77  ? 601  FAD B "O3'" 1 ? 
HETATM 8400 C "C4'" . FAD G 3 .   ? -43.122 25.196  21.753 1.00 19.40  ? 601  FAD B "C4'" 1 ? 
HETATM 8401 O "O4'" . FAD G 3 .   ? -43.968 24.846  20.647 1.00 17.95  ? 601  FAD B "O4'" 1 ? 
HETATM 8402 C "C5'" . FAD G 3 .   ? -43.499 24.367  22.968 1.00 19.29  ? 601  FAD B "C5'" 1 ? 
HETATM 8403 O "O5'" . FAD G 3 .   ? -43.297 22.965  22.697 1.00 19.96  ? 601  FAD B "O5'" 1 ? 
HETATM 8404 P P     . FAD G 3 .   ? -43.634 21.859  23.789 1.00 19.37  ? 601  FAD B P     1 ? 
HETATM 8405 O O1P   . FAD G 3 .   ? -43.640 20.536  23.100 1.00 19.62  ? 601  FAD B O1P   1 ? 
HETATM 8406 O O2P   . FAD G 3 .   ? -42.796 22.087  25.011 1.00 20.26  ? 601  FAD B O2P   1 ? 
HETATM 8407 O O3P   . FAD G 3 .   ? -45.157 22.207  24.152 1.00 20.36  ? 601  FAD B O3P   1 ? 
HETATM 8408 O O1    . HEZ H 4 .   ? -45.023 41.864  15.928 1.00 60.00  ? 602  HEZ B O1    1 ? 
HETATM 8409 C C1    . HEZ H 4 .   ? -43.888 41.127  16.408 1.00 61.49  ? 602  HEZ B C1    1 ? 
HETATM 8410 C C2    . HEZ H 4 .   ? -43.955 39.643  16.087 1.00 64.46  ? 602  HEZ B C2    1 ? 
HETATM 8411 C C3    . HEZ H 4 .   ? -43.400 38.745  17.187 1.00 62.48  ? 602  HEZ B C3    1 ? 
HETATM 8412 C C4    . HEZ H 4 .   ? -43.155 37.312  16.737 1.00 62.46  ? 602  HEZ B C4    1 ? 
HETATM 8413 C C5    . HEZ H 4 .   ? -42.469 36.437  17.787 1.00 57.98  ? 602  HEZ B C5    1 ? 
HETATM 8414 C C6    . HEZ H 4 .   ? -43.288 35.233  18.306 1.00 56.57  ? 602  HEZ B C6    1 ? 
HETATM 8415 O O6    . HEZ H 4 .   ? -42.466 34.159  18.864 1.00 51.21  ? 602  HEZ B O6    1 ? 
HETATM 8416 O O     . HOH I 5 .   ? -17.388 -16.349 5.795  1.00 32.24  ? 701  HOH A O     1 ? 
HETATM 8417 O O     . HOH I 5 .   ? 7.960   11.018  11.741 1.00 25.30  ? 702  HOH A O     1 ? 
HETATM 8418 O O     . HOH I 5 .   ? 7.674   21.108  41.556 1.00 36.90  ? 703  HOH A O     1 ? 
HETATM 8419 O O     . HOH I 5 .   ? -14.361 8.494   -2.140 1.00 52.98  ? 704  HOH A O     1 ? 
HETATM 8420 O O     . HOH I 5 .   ? -4.148  -21.952 39.985 1.00 31.59  ? 705  HOH A O     1 ? 
HETATM 8421 O O     . HOH I 5 .   ? 13.504  17.892  15.192 1.00 36.28  ? 706  HOH A O     1 ? 
HETATM 8422 O O     . HOH I 5 .   ? -13.113 -23.904 25.850 1.00 30.90  ? 707  HOH A O     1 ? 
HETATM 8423 O O     . HOH I 5 .   ? -2.994  -15.385 39.632 1.00 22.16  ? 708  HOH A O     1 ? 
HETATM 8424 O O     . HOH I 5 .   ? 11.057  15.337  40.987 1.00 27.68  ? 709  HOH A O     1 ? 
HETATM 8425 O O     . HOH I 5 .   ? -21.595 9.694   35.187 1.00 49.13  ? 710  HOH A O     1 ? 
HETATM 8426 O O     . HOH I 5 .   ? -1.778  15.717  54.374 1.00 31.69  ? 711  HOH A O     1 ? 
HETATM 8427 O O     . HOH I 5 .   ? 13.703  -7.814  1.764  1.00 45.79  ? 712  HOH A O     1 ? 
HETATM 8428 O O     . HOH I 5 .   ? 0.665   4.780   6.748  1.00 31.81  ? 713  HOH A O     1 ? 
HETATM 8429 O O     . HOH I 5 .   ? -5.121  6.019   44.762 1.00 22.94  ? 714  HOH A O     1 ? 
HETATM 8430 O O     . HOH I 5 .   ? -15.221 -15.340 27.868 1.00 33.86  ? 715  HOH A O     1 ? 
HETATM 8431 O O     . HOH I 5 .   ? -16.334 -0.949  4.612  1.00 37.64  ? 716  HOH A O     1 ? 
HETATM 8432 O O     . HOH I 5 .   ? -0.950  -34.094 6.210  1.00 45.27  ? 717  HOH A O     1 ? 
HETATM 8433 O O     . HOH I 5 .   ? -18.963 13.015  31.212 1.00 31.88  ? 718  HOH A O     1 ? 
HETATM 8434 O O     . HOH I 5 .   ? -15.163 15.668  20.024 1.00 42.09  ? 719  HOH A O     1 ? 
HETATM 8435 O O     . HOH I 5 .   ? -5.438  10.013  47.620 1.00 31.17  ? 720  HOH A O     1 ? 
HETATM 8436 O O     . HOH I 5 .   ? -10.602 -28.180 21.924 1.00 40.63  ? 721  HOH A O     1 ? 
HETATM 8437 O O     . HOH I 5 .   ? -0.093  5.464   45.153 1.00 22.98  ? 722  HOH A O     1 ? 
HETATM 8438 O O     . HOH I 5 .   ? -9.903  16.227  15.050 1.00 28.87  ? 723  HOH A O     1 ? 
HETATM 8439 O O     . HOH I 5 .   ? 5.989   28.043  16.920 1.00 47.06  ? 724  HOH A O     1 ? 
HETATM 8440 O O     . HOH I 5 .   ? -22.663 -0.698  22.215 1.00 50.77  ? 725  HOH A O     1 ? 
HETATM 8441 O O     . HOH I 5 .   ? -1.235  -8.925  1.116  1.00 34.28  ? 726  HOH A O     1 ? 
HETATM 8442 O O     . HOH I 5 .   ? 4.013   -16.623 41.907 1.00 33.95  ? 727  HOH A O     1 ? 
HETATM 8443 O O     . HOH I 5 .   ? -19.388 -12.703 23.294 1.00 43.07  ? 728  HOH A O     1 ? 
HETATM 8444 O O     . HOH I 5 .   ? -16.574 7.646   35.651 1.00 26.39  ? 729  HOH A O     1 ? 
HETATM 8445 O O     . HOH I 5 .   ? 7.421   -23.078 29.415 1.00 34.27  ? 730  HOH A O     1 ? 
HETATM 8446 O O     . HOH I 5 .   ? 12.569  -7.904  31.326 1.00 33.12  ? 731  HOH A O     1 ? 
HETATM 8447 O O     . HOH I 5 .   ? -20.892 -8.057  19.047 1.00 50.22  ? 732  HOH A O     1 ? 
HETATM 8448 O O     . HOH I 5 .   ? -15.424 -26.321 15.979 1.00 42.94  ? 733  HOH A O     1 ? 
HETATM 8449 O O     . HOH I 5 .   ? -15.898 -22.040 37.030 1.00 30.05  ? 734  HOH A O     1 ? 
HETATM 8450 O O     . HOH I 5 .   ? -14.805 -16.251 34.624 1.00 42.54  ? 735  HOH A O     1 ? 
HETATM 8451 O O     . HOH I 5 .   ? -10.035 -7.624  40.026 1.00 38.00  ? 736  HOH A O     1 ? 
HETATM 8452 O O     . HOH I 5 .   ? 4.487   -1.787  25.999 1.00 22.29  ? 737  HOH A O     1 ? 
HETATM 8453 O O     . HOH I 5 .   ? -5.634  -0.088  1.633  1.00 33.52  ? 738  HOH A O     1 ? 
HETATM 8454 O O     . HOH I 5 .   ? -21.938 8.946   30.335 1.00 42.27  ? 739  HOH A O     1 ? 
HETATM 8455 O O     . HOH I 5 .   ? 14.016  -3.708  30.992 1.00 20.29  ? 740  HOH A O     1 ? 
HETATM 8456 O O     . HOH I 5 .   ? -14.383 2.670   34.244 1.00 37.64  ? 741  HOH A O     1 ? 
HETATM 8457 O O     . HOH I 5 .   ? -16.019 -3.322  5.860  1.00 39.08  ? 742  HOH A O     1 ? 
HETATM 8458 O O     . HOH I 5 .   ? 19.001  0.958   24.783 1.00 36.67  ? 743  HOH A O     1 ? 
HETATM 8459 O O     . HOH I 5 .   ? 5.351   31.008  25.613 1.00 33.97  ? 744  HOH A O     1 ? 
HETATM 8460 O O     . HOH I 5 .   ? 17.352  6.672   23.822 1.00 40.83  ? 745  HOH A O     1 ? 
HETATM 8461 O O     . HOH I 5 .   ? -0.171  2.154   24.981 1.00 17.35  ? 746  HOH A O     1 ? 
HETATM 8462 O O     . HOH I 5 .   ? 7.538   6.081   5.365  1.00 33.72  ? 747  HOH A O     1 ? 
HETATM 8463 O O     . HOH I 5 .   ? -8.586  -24.619 3.022  1.00 45.05  ? 748  HOH A O     1 ? 
HETATM 8464 O O     . HOH I 5 .   ? 16.015  9.126   16.610 1.00 28.77  ? 749  HOH A O     1 ? 
HETATM 8465 O O     . HOH I 5 .   ? 13.100  2.939   38.855 1.00 24.32  ? 750  HOH A O     1 ? 
HETATM 8466 O O     . HOH I 5 .   ? -2.968  27.429  31.890 1.00 34.00  ? 751  HOH A O     1 ? 
HETATM 8467 O O     . HOH I 5 .   ? 11.611  24.497  37.069 1.00 24.49  ? 752  HOH A O     1 ? 
HETATM 8468 O O     . HOH I 5 .   ? -11.664 -7.254  3.981  1.00 48.37  ? 753  HOH A O     1 ? 
HETATM 8469 O O     . HOH I 5 .   ? 1.277   25.300  42.953 1.00 23.45  ? 754  HOH A O     1 ? 
HETATM 8470 O O     . HOH I 5 .   ? 3.885   -12.138 6.140  1.00 29.85  ? 755  HOH A O     1 ? 
HETATM 8471 O O     . HOH I 5 .   ? -15.650 5.669   9.650  1.00 28.80  ? 756  HOH A O     1 ? 
HETATM 8472 O O     . HOH I 5 .   ? -6.616  28.592  38.255 1.00 38.82  ? 757  HOH A O     1 ? 
HETATM 8473 O O     . HOH I 5 .   ? 2.249   -17.587 38.852 1.00 33.52  ? 758  HOH A O     1 ? 
HETATM 8474 O O     . HOH I 5 .   ? 7.718   2.907   44.937 1.00 37.85  ? 759  HOH A O     1 ? 
HETATM 8475 O O     . HOH I 5 .   ? 0.238   17.354  5.218  1.00 32.87  ? 760  HOH A O     1 ? 
HETATM 8476 O O     . HOH I 5 .   ? 7.832   -29.629 7.877  1.00 38.93  ? 761  HOH A O     1 ? 
HETATM 8477 O O     . HOH I 5 .   ? 2.615   8.711   52.942 1.00 39.55  ? 762  HOH A O     1 ? 
HETATM 8478 O O     . HOH I 5 .   ? 3.346   2.369   24.172 1.00 23.90  ? 763  HOH A O     1 ? 
HETATM 8479 O O     . HOH I 5 .   ? -13.607 -8.123  38.855 1.00 54.79  ? 764  HOH A O     1 ? 
HETATM 8480 O O     . HOH I 5 .   ? -23.597 11.344  23.656 1.00 41.27  ? 765  HOH A O     1 ? 
HETATM 8481 O O     . HOH I 5 .   ? -9.034  10.447  40.797 1.00 21.87  ? 766  HOH A O     1 ? 
HETATM 8482 O O     . HOH I 5 .   ? -16.445 -4.163  14.103 1.00 36.21  ? 767  HOH A O     1 ? 
HETATM 8483 O O     . HOH I 5 .   ? 24.558  21.155  32.244 1.00 27.62  ? 768  HOH A O     1 ? 
HETATM 8484 O O     . HOH I 5 .   ? 9.730   3.543   12.443 1.00 25.35  ? 769  HOH A O     1 ? 
HETATM 8485 O O     . HOH I 5 .   ? -19.734 6.614   9.146  1.00 41.99  ? 770  HOH A O     1 ? 
HETATM 8486 O O     . HOH I 5 .   ? -11.517 19.586  39.083 1.00 40.66  ? 771  HOH A O     1 ? 
HETATM 8487 O O     . HOH I 5 .   ? 3.097   -1.660  2.055  1.00 36.03  ? 772  HOH A O     1 ? 
HETATM 8488 O O     . HOH I 5 .   ? 17.343  6.514   34.128 1.00 25.36  ? 773  HOH A O     1 ? 
HETATM 8489 O O     . HOH I 5 .   ? 0.079   13.053  5.272  1.00 31.74  ? 774  HOH A O     1 ? 
HETATM 8490 O O     . HOH I 5 .   ? -7.099  20.997  33.916 1.00 27.60  ? 775  HOH A O     1 ? 
HETATM 8491 O O     . HOH I 5 .   ? 7.714   -24.294 25.798 1.00 37.96  ? 776  HOH A O     1 ? 
HETATM 8492 O O     . HOH I 5 .   ? 1.791   -8.542  8.948  1.00 39.92  ? 777  HOH A O     1 ? 
HETATM 8493 O O     . HOH I 5 .   ? -15.459 12.177  42.696 1.00 37.71  ? 778  HOH A O     1 ? 
HETATM 8494 O O     . HOH I 5 .   ? -6.885  -4.490  10.165 1.00 26.90  ? 779  HOH A O     1 ? 
HETATM 8495 O O     . HOH I 5 .   ? -14.782 16.696  41.089 1.00 41.70  ? 780  HOH A O     1 ? 
HETATM 8496 O O     . HOH I 5 .   ? -1.978  -26.380 21.203 1.00 35.08  ? 781  HOH A O     1 ? 
HETATM 8497 O O     . HOH I 5 .   ? -20.607 -17.000 11.318 1.00 50.95  ? 782  HOH A O     1 ? 
HETATM 8498 O O     . HOH I 5 .   ? -2.799  30.636  38.926 1.00 45.36  ? 783  HOH A O     1 ? 
HETATM 8499 O O     . HOH I 5 .   ? 6.864   5.981   24.902 1.00 17.32  ? 784  HOH A O     1 ? 
HETATM 8500 O O     . HOH I 5 .   ? -6.185  25.833  17.032 1.00 43.68  ? 785  HOH A O     1 ? 
HETATM 8501 O O     . HOH I 5 .   ? -11.508 0.058   33.218 1.00 23.97  ? 786  HOH A O     1 ? 
HETATM 8502 O O     . HOH I 5 .   ? -15.357 12.788  9.584  1.00 36.01  ? 787  HOH A O     1 ? 
HETATM 8503 O O     . HOH I 5 .   ? 6.573   18.571  42.545 1.00 24.38  ? 788  HOH A O     1 ? 
HETATM 8504 O O     . HOH I 5 .   ? -13.427 -28.946 8.011  1.00 42.24  ? 789  HOH A O     1 ? 
HETATM 8505 O O     . HOH I 5 .   ? 7.503   8.693   13.170 1.00 24.12  ? 790  HOH A O     1 ? 
HETATM 8506 O O     . HOH I 5 .   ? -20.784 8.757   12.911 1.00 36.35  ? 791  HOH A O     1 ? 
HETATM 8507 O O     . HOH I 5 .   ? -14.323 1.098   28.686 1.00 39.68  ? 792  HOH A O     1 ? 
HETATM 8508 O O     . HOH I 5 .   ? 0.596   -16.747 16.132 1.00 24.79  ? 793  HOH A O     1 ? 
HETATM 8509 O O     . HOH I 5 .   ? 6.631   -7.883  42.389 1.00 31.70  ? 794  HOH A O     1 ? 
HETATM 8510 O O     . HOH I 5 .   ? 7.670   -12.231 28.423 1.00 25.22  ? 795  HOH A O     1 ? 
HETATM 8511 O O     . HOH I 5 .   ? -6.976  -6.937  39.698 1.00 23.16  ? 796  HOH A O     1 ? 
HETATM 8512 O O     . HOH I 5 .   ? -6.526  -15.098 36.708 1.00 18.05  ? 797  HOH A O     1 ? 
HETATM 8513 O O     . HOH I 5 .   ? 10.642  11.940  12.331 1.00 23.54  ? 798  HOH A O     1 ? 
HETATM 8514 O O     . HOH I 5 .   ? -10.019 0.076   37.667 1.00 35.23  ? 799  HOH A O     1 ? 
HETATM 8515 O O     . HOH I 5 .   ? 9.482   0.777   27.789 1.00 18.27  ? 800  HOH A O     1 ? 
HETATM 8516 O O     . HOH I 5 .   ? 19.586  26.369  30.977 1.00 33.51  ? 801  HOH A O     1 ? 
HETATM 8517 O O     . HOH I 5 .   ? -16.818 -17.522 17.654 1.00 33.29  ? 802  HOH A O     1 ? 
HETATM 8518 O O     . HOH I 5 .   ? -1.308  13.350  55.776 1.00 39.09  ? 803  HOH A O     1 ? 
HETATM 8519 O O     . HOH I 5 .   ? 12.570  20.297  15.108 1.00 38.71  ? 804  HOH A O     1 ? 
HETATM 8520 O O     . HOH I 5 .   ? 15.992  13.585  25.815 1.00 31.12  ? 805  HOH A O     1 ? 
HETATM 8521 O O     . HOH I 5 .   ? 1.338   -29.994 26.549 1.00 29.65  ? 806  HOH A O     1 ? 
HETATM 8522 O O     . HOH I 5 .   ? -4.403  -0.455  43.703 1.00 36.57  ? 807  HOH A O     1 ? 
HETATM 8523 O O     . HOH I 5 .   ? 10.802  8.515   32.373 1.00 24.06  ? 808  HOH A O     1 ? 
HETATM 8524 O O     . HOH I 5 .   ? -8.424  23.310  41.724 1.00 34.40  ? 809  HOH A O     1 ? 
HETATM 8525 O O     . HOH I 5 .   ? 5.662   -9.668  24.953 1.00 19.80  ? 810  HOH A O     1 ? 
HETATM 8526 O O     . HOH I 5 .   ? 12.734  18.078  38.325 1.00 29.00  ? 811  HOH A O     1 ? 
HETATM 8527 O O     . HOH I 5 .   ? -2.822  4.516   44.794 1.00 38.35  ? 812  HOH A O     1 ? 
HETATM 8528 O O     . HOH I 5 .   ? -0.672  -25.261 36.720 1.00 33.72  ? 813  HOH A O     1 ? 
HETATM 8529 O O     . HOH I 5 .   ? -15.973 1.043   -0.729 1.00 50.73  ? 814  HOH A O     1 ? 
HETATM 8530 O O     . HOH I 5 .   ? 3.746   -20.661 23.812 1.00 30.55  ? 815  HOH A O     1 ? 
HETATM 8531 O O     . HOH I 5 .   ? -9.592  -18.929 38.266 1.00 31.37  ? 816  HOH A O     1 ? 
HETATM 8532 O O     . HOH I 5 .   ? 2.808   8.468   15.457 1.00 22.23  ? 817  HOH A O     1 ? 
HETATM 8533 O O     . HOH I 5 .   ? 3.041   32.795  15.322 1.00 50.18  ? 818  HOH A O     1 ? 
HETATM 8534 O O     . HOH I 5 .   ? -14.776 4.471   41.008 1.00 37.52  ? 819  HOH A O     1 ? 
HETATM 8535 O O     . HOH I 5 .   ? 7.796   -8.335  25.836 1.00 23.32  ? 820  HOH A O     1 ? 
HETATM 8536 O O     . HOH I 5 .   ? -14.555 -8.111  16.685 1.00 37.18  ? 821  HOH A O     1 ? 
HETATM 8537 O O     . HOH I 5 .   ? -11.809 -4.816  36.540 1.00 30.82  ? 822  HOH A O     1 ? 
HETATM 8538 O O     . HOH I 5 .   ? -4.909  -0.678  16.283 1.00 17.06  ? 823  HOH A O     1 ? 
HETATM 8539 O O     . HOH I 5 .   ? -0.469  28.118  10.410 1.00 47.27  ? 824  HOH A O     1 ? 
HETATM 8540 O O     . HOH I 5 .   ? -10.197 20.416  35.832 1.00 26.81  ? 825  HOH A O     1 ? 
HETATM 8541 O O     . HOH I 5 .   ? 1.249   -3.442  4.750  1.00 31.79  ? 826  HOH A O     1 ? 
HETATM 8542 O O     . HOH I 5 .   ? -12.222 -11.316 27.122 1.00 23.91  ? 827  HOH A O     1 ? 
HETATM 8543 O O     . HOH I 5 .   ? 3.567   4.472   25.838 1.00 20.65  ? 828  HOH A O     1 ? 
HETATM 8544 O O     . HOH I 5 .   ? 4.327   -17.745 16.375 1.00 31.66  ? 829  HOH A O     1 ? 
HETATM 8545 O O     . HOH I 5 .   ? 0.942   -10.905 38.334 1.00 23.23  ? 830  HOH A O     1 ? 
HETATM 8546 O O     . HOH I 5 .   ? 1.925   -32.383 20.830 1.00 32.86  ? 831  HOH A O     1 ? 
HETATM 8547 O O     . HOH I 5 .   ? -6.317  21.275  43.537 1.00 29.29  ? 832  HOH A O     1 ? 
HETATM 8548 O O     . HOH I 5 .   ? -8.365  -6.089  6.564  1.00 31.99  ? 833  HOH A O     1 ? 
HETATM 8549 O O     . HOH I 5 .   ? -6.556  6.012   36.171 1.00 17.17  ? 834  HOH A O     1 ? 
HETATM 8550 O O     . HOH I 5 .   ? -1.338  5.097   41.757 1.00 21.97  ? 835  HOH A O     1 ? 
HETATM 8551 O O     . HOH I 5 .   ? -14.189 -8.761  31.375 1.00 41.66  ? 836  HOH A O     1 ? 
HETATM 8552 O O     . HOH I 5 .   ? 15.198  8.553   19.300 1.00 21.94  ? 837  HOH A O     1 ? 
HETATM 8553 O O     . HOH I 5 .   ? -2.973  19.827  9.832  1.00 28.07  ? 838  HOH A O     1 ? 
HETATM 8554 O O     . HOH I 5 .   ? 14.690  1.534   31.252 1.00 36.26  ? 839  HOH A O     1 ? 
HETATM 8555 O O     . HOH I 5 .   ? -8.856  -4.578  1.693  1.00 49.48  ? 840  HOH A O     1 ? 
HETATM 8556 O O     . HOH I 5 .   ? -14.694 -0.743  14.572 1.00 24.45  ? 841  HOH A O     1 ? 
HETATM 8557 O O     . HOH I 5 .   ? -13.081 -16.865 38.544 1.00 23.50  ? 842  HOH A O     1 ? 
HETATM 8558 O O     . HOH I 5 .   ? -3.409  32.975  25.438 1.00 50.56  ? 843  HOH A O     1 ? 
HETATM 8559 O O     . HOH I 5 .   ? 1.718   10.812  22.075 1.00 18.43  ? 844  HOH A O     1 ? 
HETATM 8560 O O     . HOH I 5 .   ? 5.038   -5.384  10.288 1.00 21.25  ? 845  HOH A O     1 ? 
HETATM 8561 O O     . HOH I 5 .   ? -16.625 -8.292  18.968 1.00 39.47  ? 846  HOH A O     1 ? 
HETATM 8562 O O     . HOH I 5 .   ? -7.991  14.015  7.715  1.00 29.07  ? 847  HOH A O     1 ? 
HETATM 8563 O O     . HOH I 5 .   ? -11.388 17.976  35.290 1.00 24.38  ? 848  HOH A O     1 ? 
HETATM 8564 O O     . HOH I 5 .   ? -11.200 11.638  44.234 1.00 32.97  ? 849  HOH A O     1 ? 
HETATM 8565 O O     . HOH I 5 .   ? 4.369   -21.763 35.258 1.00 36.85  ? 850  HOH A O     1 ? 
HETATM 8566 O O     . HOH I 5 .   ? -5.547  -11.845 43.615 1.00 33.65  ? 851  HOH A O     1 ? 
HETATM 8567 O O     . HOH I 5 .   ? 5.806   -22.913 7.910  1.00 27.63  ? 852  HOH A O     1 ? 
HETATM 8568 O O     . HOH I 5 .   ? 9.520   -10.897 10.160 1.00 32.98  ? 853  HOH A O     1 ? 
HETATM 8569 O O     . HOH I 5 .   ? -17.933 -20.073 10.805 1.00 40.65  ? 854  HOH A O     1 ? 
HETATM 8570 O O     . HOH I 5 .   ? -8.782  5.126   37.598 1.00 21.80  ? 855  HOH A O     1 ? 
HETATM 8571 O O     . HOH I 5 .   ? 19.064  23.787  27.064 1.00 23.20  ? 856  HOH A O     1 ? 
HETATM 8572 O O     . HOH I 5 .   ? -19.361 -10.761 26.880 1.00 43.28  ? 857  HOH A O     1 ? 
HETATM 8573 O O     . HOH I 5 .   ? 4.914   20.924  39.890 1.00 30.40  ? 858  HOH A O     1 ? 
HETATM 8574 O O     . HOH I 5 .   ? -10.905 16.494  42.382 1.00 45.38  ? 859  HOH A O     1 ? 
HETATM 8575 O O     . HOH I 5 .   ? 2.910   -0.113  24.398 1.00 25.33  ? 860  HOH A O     1 ? 
HETATM 8576 O O     . HOH I 5 .   ? 16.460  2.786   27.947 1.00 23.18  ? 861  HOH A O     1 ? 
HETATM 8577 O O     . HOH I 5 .   ? -4.741  -10.618 33.418 1.00 18.20  ? 862  HOH A O     1 ? 
HETATM 8578 O O     . HOH I 5 .   ? -19.579 -14.246 12.356 1.00 38.47  ? 863  HOH A O     1 ? 
HETATM 8579 O O     . HOH I 5 .   ? -8.058  -6.044  3.839  1.00 41.13  ? 864  HOH A O     1 ? 
HETATM 8580 O O     . HOH I 5 .   ? -13.980 -11.842 38.776 1.00 33.28  ? 865  HOH A O     1 ? 
HETATM 8581 O O     . HOH I 5 .   ? 17.442  7.925   42.380 1.00 40.73  ? 866  HOH A O     1 ? 
HETATM 8582 O O     . HOH I 5 .   ? -20.492 12.739  20.973 1.00 38.70  ? 867  HOH A O     1 ? 
HETATM 8583 O O     . HOH I 5 .   ? -11.754 9.486   4.262  1.00 22.94  ? 868  HOH A O     1 ? 
HETATM 8584 O O     . HOH I 5 .   ? -15.914 -6.015  28.550 1.00 37.54  ? 869  HOH A O     1 ? 
HETATM 8585 O O     . HOH I 5 .   ? -11.662 -4.099  14.836 1.00 36.68  ? 870  HOH A O     1 ? 
HETATM 8586 O O     . HOH I 5 .   ? 3.862   -4.894  31.658 1.00 25.67  ? 871  HOH A O     1 ? 
HETATM 8587 O O     . HOH I 5 .   ? 0.861   4.776   25.799 1.00 13.29  ? 872  HOH A O     1 ? 
HETATM 8588 O O     . HOH I 5 .   ? -5.507  -0.061  40.057 1.00 22.73  ? 873  HOH A O     1 ? 
HETATM 8589 O O     . HOH I 5 .   ? 10.163  23.252  14.833 1.00 37.45  ? 874  HOH A O     1 ? 
HETATM 8590 O O     . HOH I 5 .   ? 13.180  23.396  17.330 1.00 44.63  ? 875  HOH A O     1 ? 
HETATM 8591 O O     . HOH I 5 .   ? -10.894 7.339   45.796 1.00 46.99  ? 876  HOH A O     1 ? 
HETATM 8592 O O     . HOH I 5 .   ? 4.888   -31.781 1.853  1.00 39.80  ? 877  HOH A O     1 ? 
HETATM 8593 O O     . HOH I 5 .   ? -6.781  13.059  51.409 1.00 28.86  ? 878  HOH A O     1 ? 
HETATM 8594 O O     . HOH I 5 .   ? -9.867  13.900  43.608 1.00 38.39  ? 879  HOH A O     1 ? 
HETATM 8595 O O     . HOH I 5 .   ? -2.297  0.935   -1.740 1.00 46.09  ? 880  HOH A O     1 ? 
HETATM 8596 O O     . HOH I 5 .   ? -15.008 21.493  23.811 1.00 44.03  ? 881  HOH A O     1 ? 
HETATM 8597 O O     . HOH I 5 .   ? -12.001 -6.453  16.641 1.00 38.88  ? 882  HOH A O     1 ? 
HETATM 8598 O O     . HOH I 5 .   ? 20.556  20.007  19.338 1.00 46.45  ? 883  HOH A O     1 ? 
HETATM 8599 O O     . HOH I 5 .   ? 8.390   29.813  27.348 1.00 28.79  ? 884  HOH A O     1 ? 
HETATM 8600 O O     . HOH I 5 .   ? 0.186   7.185   6.106  1.00 30.17  ? 885  HOH A O     1 ? 
HETATM 8601 O O     . HOH I 5 .   ? -15.140 6.162   22.764 1.00 20.30  ? 886  HOH A O     1 ? 
HETATM 8602 O O     . HOH I 5 .   ? 2.121   28.280  43.099 1.00 40.88  ? 887  HOH A O     1 ? 
HETATM 8603 O O     . HOH I 5 .   ? -16.036 19.213  25.414 1.00 40.97  ? 888  HOH A O     1 ? 
HETATM 8604 O O     . HOH I 5 .   ? 10.959  16.261  38.348 1.00 21.93  ? 889  HOH A O     1 ? 
HETATM 8605 O O     . HOH I 5 .   ? -8.668  -10.805 42.804 1.00 29.10  ? 890  HOH A O     1 ? 
HETATM 8606 O O     . HOH I 5 .   ? 3.915   -8.640  6.708  1.00 45.98  ? 891  HOH A O     1 ? 
HETATM 8607 O O     . HOH I 5 .   ? -1.242  29.579  31.408 1.00 43.24  ? 892  HOH A O     1 ? 
HETATM 8608 O O     . HOH I 5 .   ? 4.375   19.826  43.864 1.00 25.19  ? 893  HOH A O     1 ? 
HETATM 8609 O O     . HOH I 5 .   ? -5.080  -7.601  21.181 1.00 28.79  ? 894  HOH A O     1 ? 
HETATM 8610 O O     . HOH I 5 .   ? 4.758   6.053   28.411 1.00 16.56  ? 895  HOH A O     1 ? 
HETATM 8611 O O     . HOH I 5 .   ? -6.852  13.536  5.046  1.00 45.20  ? 896  HOH A O     1 ? 
HETATM 8612 O O     . HOH I 5 .   ? -12.162 -10.126 41.617 1.00 38.88  ? 897  HOH A O     1 ? 
HETATM 8613 O O     . HOH I 5 .   ? -15.866 11.093  5.076  1.00 43.89  ? 898  HOH A O     1 ? 
HETATM 8614 O O     . HOH I 5 .   ? 10.906  -20.211 14.763 1.00 37.03  ? 899  HOH A O     1 ? 
HETATM 8615 O O     . HOH I 5 .   ? 10.121  -6.883  40.974 1.00 26.03  ? 900  HOH A O     1 ? 
HETATM 8616 O O     . HOH I 5 .   ? 9.307   -16.885 1.177  1.00 43.43  ? 901  HOH A O     1 ? 
HETATM 8617 O O     . HOH I 5 .   ? -16.633 7.501   43.524 1.00 33.63  ? 902  HOH A O     1 ? 
HETATM 8618 O O     . HOH I 5 .   ? -11.666 0.454   24.864 1.00 27.98  ? 903  HOH A O     1 ? 
HETATM 8619 O O     . HOH I 5 .   ? 13.829  6.694   9.046  1.00 44.26  ? 904  HOH A O     1 ? 
HETATM 8620 O O     . HOH I 5 .   ? -22.406 5.346   19.423 1.00 35.55  ? 905  HOH A O     1 ? 
HETATM 8621 O O     . HOH I 5 .   ? -17.342 -10.307 7.832  1.00 38.50  ? 906  HOH A O     1 ? 
HETATM 8622 O O     . HOH I 5 .   ? 21.688  7.676   20.873 1.00 37.42  ? 907  HOH A O     1 ? 
HETATM 8623 O O     . HOH I 5 .   ? 7.262   5.466   27.474 1.00 20.20  ? 908  HOH A O     1 ? 
HETATM 8624 O O     . HOH I 5 .   ? -16.679 13.873  32.421 1.00 29.28  ? 909  HOH A O     1 ? 
HETATM 8625 O O     . HOH I 5 .   ? -8.682  -8.362  3.193  1.00 47.86  ? 910  HOH A O     1 ? 
HETATM 8626 O O     . HOH I 5 .   ? 12.837  9.842   46.133 1.00 28.21  ? 911  HOH A O     1 ? 
HETATM 8627 O O     . HOH I 5 .   ? 11.803  -12.609 34.796 1.00 29.55  ? 912  HOH A O     1 ? 
HETATM 8628 O O     . HOH I 5 .   ? 14.418  28.641  31.052 1.00 26.26  ? 913  HOH A O     1 ? 
HETATM 8629 O O     . HOH I 5 .   ? 17.398  2.817   25.346 1.00 22.67  ? 914  HOH A O     1 ? 
HETATM 8630 O O     . HOH I 5 .   ? 9.474   -10.443 29.008 1.00 24.78  ? 915  HOH A O     1 ? 
HETATM 8631 O O     . HOH I 5 .   ? 10.584  9.172   39.324 1.00 19.27  ? 916  HOH A O     1 ? 
HETATM 8632 O O     . HOH I 5 .   ? 1.039   -6.529  43.198 1.00 33.28  ? 917  HOH A O     1 ? 
HETATM 8633 O O     . HOH I 5 .   ? -1.419  11.336  4.459  1.00 39.03  ? 918  HOH A O     1 ? 
HETATM 8634 O O     . HOH I 5 .   ? -4.166  -5.657  33.754 1.00 25.81  ? 919  HOH A O     1 ? 
HETATM 8635 O O     . HOH I 5 .   ? 7.281   -27.053 26.793 1.00 33.55  ? 920  HOH A O     1 ? 
HETATM 8636 O O     . HOH I 5 .   ? 6.995   13.554  11.206 1.00 32.83  ? 921  HOH A O     1 ? 
HETATM 8637 O O     . HOH I 5 .   ? 15.419  4.466   42.123 1.00 47.75  ? 922  HOH A O     1 ? 
HETATM 8638 O O     . HOH I 5 .   ? -15.520 -7.882  4.758  1.00 43.91  ? 923  HOH A O     1 ? 
HETATM 8639 O O     . HOH I 5 .   ? 3.810   -3.634  27.851 1.00 17.58  ? 924  HOH A O     1 ? 
HETATM 8640 O O     . HOH I 5 .   ? 17.823  19.131  21.271 1.00 38.27  ? 925  HOH A O     1 ? 
HETATM 8641 O O     . HOH I 5 .   ? -26.949 11.737  23.912 1.00 55.27  ? 926  HOH A O     1 ? 
HETATM 8642 O O     . HOH I 5 .   ? 3.667   -6.102  5.510  1.00 34.45  ? 927  HOH A O     1 ? 
HETATM 8643 O O     . HOH I 5 .   ? -23.264 1.815   13.850 1.00 53.83  ? 928  HOH A O     1 ? 
HETATM 8644 O O     . HOH I 5 .   ? 15.546  3.575   36.434 1.00 27.69  ? 929  HOH A O     1 ? 
HETATM 8645 O O     . HOH I 5 .   ? -10.778 -4.731  30.428 1.00 35.80  ? 930  HOH A O     1 ? 
HETATM 8646 O O     . HOH I 5 .   ? -9.228  -2.010  12.380 1.00 19.91  ? 931  HOH A O     1 ? 
HETATM 8647 O O     . HOH I 5 .   ? 2.376   -1.943  42.281 1.00 22.21  ? 932  HOH A O     1 ? 
HETATM 8648 O O     . HOH I 5 .   ? -6.446  -4.757  41.486 1.00 45.35  ? 933  HOH A O     1 ? 
HETATM 8649 O O     . HOH I 5 .   ? 9.928   6.562   39.028 1.00 20.59  ? 934  HOH A O     1 ? 
HETATM 8650 O O     . HOH I 5 .   ? -18.651 0.999   30.525 1.00 45.77  ? 935  HOH A O     1 ? 
HETATM 8651 O O     . HOH I 5 .   ? 2.547   30.623  31.303 1.00 30.73  ? 936  HOH A O     1 ? 
HETATM 8652 O O     . HOH I 5 .   ? -5.291  -10.428 28.669 1.00 24.84  ? 937  HOH A O     1 ? 
HETATM 8653 O O     . HOH I 5 .   ? -4.709  7.386   54.644 1.00 53.74  ? 938  HOH A O     1 ? 
HETATM 8654 O O     . HOH I 5 .   ? 12.084  -1.195  34.133 1.00 22.03  ? 939  HOH A O     1 ? 
HETATM 8655 O O     . HOH I 5 .   ? -3.565  19.011  7.463  1.00 41.45  ? 940  HOH A O     1 ? 
HETATM 8656 O O     . HOH I 5 .   ? -4.112  -8.240  32.198 1.00 15.27  ? 941  HOH A O     1 ? 
HETATM 8657 O O     . HOH I 5 .   ? -9.985  -18.133 1.687  1.00 38.94  ? 942  HOH A O     1 ? 
HETATM 8658 O O     . HOH I 5 .   ? -15.278 -12.805 28.784 1.00 29.81  ? 943  HOH A O     1 ? 
HETATM 8659 O O     . HOH I 5 .   ? -15.707 15.178  10.706 1.00 43.75  ? 944  HOH A O     1 ? 
HETATM 8660 O O     . HOH I 5 .   ? -10.301 -12.485 41.785 1.00 26.13  ? 945  HOH A O     1 ? 
HETATM 8661 O O     . HOH I 5 .   ? -4.607  28.704  41.644 1.00 32.00  ? 946  HOH A O     1 ? 
HETATM 8662 O O     . HOH I 5 .   ? -23.951 3.563   31.805 1.00 36.71  ? 947  HOH A O     1 ? 
HETATM 8663 O O     . HOH I 5 .   ? -14.565 -2.183  27.547 1.00 42.30  ? 948  HOH A O     1 ? 
HETATM 8664 O O     . HOH I 5 .   ? 1.790   -8.570  40.068 1.00 25.19  ? 949  HOH A O     1 ? 
HETATM 8665 O O     . HOH I 5 .   ? 6.373   15.250  4.419  1.00 45.34  ? 950  HOH A O     1 ? 
HETATM 8666 O O     . HOH I 5 .   ? 7.721   28.900  37.199 1.00 48.84  ? 951  HOH A O     1 ? 
HETATM 8667 O O     . HOH I 5 .   ? -11.185 2.967   38.389 1.00 35.10  ? 952  HOH A O     1 ? 
HETATM 8668 O O     . HOH I 5 .   ? -8.390  16.968  43.105 1.00 27.53  ? 953  HOH A O     1 ? 
HETATM 8669 O O     . HOH I 5 .   ? -6.805  24.757  14.831 1.00 44.08  ? 954  HOH A O     1 ? 
HETATM 8670 O O     . HOH I 5 .   ? -5.314  -27.907 3.442  1.00 44.01  ? 955  HOH A O     1 ? 
HETATM 8671 O O     . HOH I 5 .   ? 14.164  5.459   33.104 1.00 25.11  ? 956  HOH A O     1 ? 
HETATM 8672 O O     . HOH I 5 .   ? -18.244 -3.436  15.947 1.00 31.08  ? 957  HOH A O     1 ? 
HETATM 8673 O O     . HOH I 5 .   ? 3.045   25.641  5.620  1.00 46.06  ? 958  HOH A O     1 ? 
HETATM 8674 O O     . HOH I 5 .   ? 16.682  14.201  15.853 1.00 42.75  ? 959  HOH A O     1 ? 
HETATM 8675 O O     . HOH I 5 .   ? 7.632   -22.942 10.166 1.00 29.94  ? 960  HOH A O     1 ? 
HETATM 8676 O O     . HOH I 5 .   ? -13.024 -1.656  25.520 1.00 34.97  ? 961  HOH A O     1 ? 
HETATM 8677 O O     . HOH I 5 .   ? 18.940  4.353   8.617  1.00 31.89  ? 962  HOH A O     1 ? 
HETATM 8678 O O     . HOH I 5 .   ? 19.507  0.033   14.933 1.00 36.62  ? 963  HOH A O     1 ? 
HETATM 8679 O O     . HOH I 5 .   ? 9.066   -19.991 13.047 1.00 27.98  ? 964  HOH A O     1 ? 
HETATM 8680 O O     . HOH I 5 .   ? -0.473  31.707  33.092 1.00 49.39  ? 965  HOH A O     1 ? 
HETATM 8681 O O     . HOH I 5 .   ? 20.951  2.517   20.500 1.00 38.30  ? 966  HOH A O     1 ? 
HETATM 8682 O O     . HOH I 5 .   ? 11.713  30.638  34.329 1.00 40.30  ? 967  HOH A O     1 ? 
HETATM 8683 O O     . HOH I 5 .   ? 4.385   -0.796  40.815 1.00 26.92  ? 968  HOH A O     1 ? 
HETATM 8684 O O     . HOH I 5 .   ? -21.985 -0.983  13.682 1.00 39.82  ? 969  HOH A O     1 ? 
HETATM 8685 O O     . HOH I 5 .   ? -1.013  6.514   47.651 1.00 28.39  ? 970  HOH A O     1 ? 
HETATM 8686 O O     . HOH I 5 .   ? -18.695 -6.964  18.873 1.00 55.01  ? 971  HOH A O     1 ? 
HETATM 8687 O O     . HOH I 5 .   ? -8.490  -1.522  8.462  1.00 24.01  ? 972  HOH A O     1 ? 
HETATM 8688 O O     . HOH I 5 .   ? 3.116   -17.373 24.490 1.00 24.63  ? 973  HOH A O     1 ? 
HETATM 8689 O O     . HOH I 5 .   ? -6.887  18.188  46.288 1.00 24.24  ? 974  HOH A O     1 ? 
HETATM 8690 O O     . HOH I 5 .   ? 0.496   24.755  2.300  1.00 41.56  ? 975  HOH A O     1 ? 
HETATM 8691 O O     . HOH I 5 .   ? 24.106  24.518  32.635 1.00 26.16  ? 976  HOH A O     1 ? 
HETATM 8692 O O     . HOH I 5 .   ? -9.945  -0.390  10.411 1.00 27.94  ? 977  HOH A O     1 ? 
HETATM 8693 O O     . HOH I 5 .   ? 10.687  -3.204  38.516 1.00 28.23  ? 978  HOH A O     1 ? 
HETATM 8694 O O     . HOH I 5 .   ? -26.592 13.886  25.406 1.00 50.17  ? 979  HOH A O     1 ? 
HETATM 8695 O O     . HOH I 5 .   ? 15.036  19.826  18.013 1.00 44.86  ? 980  HOH A O     1 ? 
HETATM 8696 O O     . HOH I 5 .   ? 2.249   -3.289  30.331 1.00 17.99  ? 981  HOH A O     1 ? 
HETATM 8697 O O     . HOH I 5 .   ? 4.946   23.822  40.187 1.00 28.94  ? 982  HOH A O     1 ? 
HETATM 8698 O O     . HOH I 5 .   ? -3.994  -2.820  0.814  1.00 28.75  ? 983  HOH A O     1 ? 
HETATM 8699 O O     . HOH I 5 .   ? 0.838   -10.502 0.006  1.00 31.21  ? 984  HOH A O     1 ? 
HETATM 8700 O O     . HOH I 5 .   ? -6.169  -15.004 40.983 1.00 26.33  ? 985  HOH A O     1 ? 
HETATM 8701 O O     . HOH I 5 .   ? 10.218  12.660  33.760 1.00 21.75  ? 986  HOH A O     1 ? 
HETATM 8702 O O     . HOH I 5 .   ? -5.766  19.196  48.478 1.00 23.69  ? 987  HOH A O     1 ? 
HETATM 8703 O O     . HOH I 5 .   ? -2.610  -35.004 10.824 1.00 47.79  ? 988  HOH A O     1 ? 
HETATM 8704 O O     . HOH I 5 .   ? -16.263 16.508  25.286 1.00 35.13  ? 989  HOH A O     1 ? 
HETATM 8705 O O     . HOH I 5 .   ? -16.904 -3.279  26.460 1.00 29.44  ? 990  HOH A O     1 ? 
HETATM 8706 O O     . HOH I 5 .   ? -5.724  -16.687 38.617 1.00 21.81  ? 991  HOH A O     1 ? 
HETATM 8707 O O     . HOH I 5 .   ? -6.225  30.532  10.612 1.00 49.53  ? 992  HOH A O     1 ? 
HETATM 8708 O O     . HOH I 5 .   ? -18.956 8.772   10.528 1.00 34.09  ? 993  HOH A O     1 ? 
HETATM 8709 O O     . HOH I 5 .   ? -7.771  2.389   42.251 1.00 42.50  ? 994  HOH A O     1 ? 
HETATM 8710 O O     . HOH I 5 .   ? 9.134   10.618  31.996 1.00 25.92  ? 995  HOH A O     1 ? 
HETATM 8711 O O     . HOH I 5 .   ? 10.563  20.416  12.331 1.00 38.43  ? 996  HOH A O     1 ? 
HETATM 8712 O O     . HOH I 5 .   ? 20.151  0.439   11.842 1.00 51.85  ? 997  HOH A O     1 ? 
HETATM 8713 O O     . HOH I 5 .   ? -16.928 15.204  34.799 1.00 27.23  ? 998  HOH A O     1 ? 
HETATM 8714 O O     . HOH I 5 .   ? 22.570  26.493  32.090 1.00 56.16  ? 999  HOH A O     1 ? 
HETATM 8715 O O     . HOH I 5 .   ? 0.718   33.239  21.803 1.00 47.30  ? 1000 HOH A O     1 ? 
HETATM 8716 O O     . HOH I 5 .   ? -12.378 1.706   35.548 1.00 43.83  ? 1001 HOH A O     1 ? 
HETATM 8717 O O     . HOH I 5 .   ? -12.904 -5.158  33.271 1.00 49.30  ? 1002 HOH A O     1 ? 
HETATM 8718 O O     . HOH I 5 .   ? -16.117 17.750  30.469 1.00 41.41  ? 1003 HOH A O     1 ? 
HETATM 8719 O O     . HOH I 5 .   ? -10.134 17.835  10.913 1.00 42.86  ? 1004 HOH A O     1 ? 
HETATM 8720 O O     . HOH I 5 .   ? -22.871 3.831   16.796 1.00 37.94  ? 1005 HOH A O     1 ? 
HETATM 8721 O O     . HOH I 5 .   ? 4.107   17.784  2.901  1.00 43.74  ? 1006 HOH A O     1 ? 
HETATM 8722 O O     . HOH I 5 .   ? -6.656  10.650  49.973 1.00 36.26  ? 1007 HOH A O     1 ? 
HETATM 8723 O O     . HOH I 5 .   ? 1.050   34.636  19.797 1.00 49.26  ? 1008 HOH A O     1 ? 
HETATM 8724 O O     . HOH I 5 .   ? 18.652  5.161   25.410 1.00 30.93  ? 1009 HOH A O     1 ? 
HETATM 8725 O O     . HOH I 5 .   ? -13.877 -25.476 23.063 1.00 38.59  ? 1010 HOH A O     1 ? 
HETATM 8726 O O     . HOH I 5 .   ? -15.624 -22.105 26.179 1.00 32.08  ? 1011 HOH A O     1 ? 
HETATM 8727 O O     . HOH I 5 .   ? 0.080   -15.906 42.714 1.00 39.90  ? 1012 HOH A O     1 ? 
HETATM 8728 O O     . HOH I 5 .   ? -4.429  -13.795 42.835 1.00 33.94  ? 1013 HOH A O     1 ? 
HETATM 8729 O O     . HOH I 5 .   ? 18.208  5.150   36.549 1.00 47.33  ? 1014 HOH A O     1 ? 
HETATM 8730 O O     . HOH I 5 .   ? -22.571 7.073   12.674 1.00 41.21  ? 1015 HOH A O     1 ? 
HETATM 8731 O O     . HOH I 5 .   ? -10.139 15.733  8.302  1.00 51.17  ? 1016 HOH A O     1 ? 
HETATM 8732 O O     . HOH I 5 .   ? 2.676   32.297  29.133 1.00 36.57  ? 1017 HOH A O     1 ? 
HETATM 8733 O O     . HOH I 5 .   ? -2.746  -17.391 41.559 1.00 39.09  ? 1018 HOH A O     1 ? 
HETATM 8734 O O     . HOH I 5 .   ? 0.742   -24.007 1.336  1.00 36.37  ? 1019 HOH A O     1 ? 
HETATM 8735 O O     . HOH I 5 .   ? 0.312   5.047   49.102 1.00 35.03  ? 1020 HOH A O     1 ? 
HETATM 8736 O O     . HOH I 5 .   ? -8.866  -4.392  8.564  1.00 29.82  ? 1021 HOH A O     1 ? 
HETATM 8737 O O     . HOH I 5 .   ? 12.867  30.679  31.986 1.00 38.55  ? 1022 HOH A O     1 ? 
HETATM 8738 O O     . HOH I 5 .   ? 14.837  17.313  39.847 1.00 41.70  ? 1023 HOH A O     1 ? 
HETATM 8739 O O     . HOH I 5 .   ? -1.980  31.495  42.570 1.00 50.74  ? 1024 HOH A O     1 ? 
HETATM 8740 O O     . HOH I 5 .   ? -18.716 3.697   35.929 1.00 43.90  ? 1025 HOH A O     1 ? 
HETATM 8741 O O     . HOH I 5 .   ? 0.447   -22.891 37.258 1.00 31.41  ? 1026 HOH A O     1 ? 
HETATM 8742 O O     . HOH I 5 .   ? 15.566  25.786  35.416 1.00 49.20  ? 1027 HOH A O     1 ? 
HETATM 8743 O O     . HOH I 5 .   ? 13.082  -3.305  35.299 1.00 34.31  ? 1028 HOH A O     1 ? 
HETATM 8744 O O     . HOH I 5 .   ? -0.809  -9.463  40.950 1.00 37.21  ? 1029 HOH A O     1 ? 
HETATM 8745 O O     . HOH I 5 .   ? -4.487  -30.607 39.234 1.00 43.50  ? 1030 HOH A O     1 ? 
HETATM 8746 O O     . HOH I 5 .   ? 14.294  0.177   33.368 1.00 37.49  ? 1031 HOH A O     1 ? 
HETATM 8747 O O     . HOH I 5 .   ? 10.247  24.933  39.321 1.00 41.85  ? 1032 HOH A O     1 ? 
HETATM 8748 O O     . HOH I 5 .   ? 13.565  7.429   46.777 1.00 46.02  ? 1033 HOH A O     1 ? 
HETATM 8749 O O     . HOH I 5 .   ? -20.000 13.437  45.281 1.00 48.94  ? 1034 HOH A O     1 ? 
HETATM 8750 O O     . HOH I 5 .   ? -15.099 -10.704 27.246 1.00 23.94  ? 1035 HOH A O     1 ? 
HETATM 8751 O O     . HOH I 5 .   ? 19.873  26.056  28.327 1.00 19.08  ? 1036 HOH A O     1 ? 
HETATM 8752 O O     . HOH I 5 .   ? -1.844  -14.008 41.684 1.00 33.64  ? 1037 HOH A O     1 ? 
HETATM 8753 O O     . HOH I 5 .   ? -9.517  19.095  14.733 1.00 29.53  ? 1038 HOH A O     1 ? 
HETATM 8754 O O     . HOH I 5 .   ? 18.597  28.411  27.698 1.00 34.19  ? 1039 HOH A O     1 ? 
HETATM 8755 O O     . HOH I 5 .   ? -9.061  3.028   39.221 1.00 37.83  ? 1040 HOH A O     1 ? 
HETATM 8756 O O     . HOH I 5 .   ? -14.041 -14.732 39.825 1.00 33.81  ? 1041 HOH A O     1 ? 
HETATM 8757 O O     . HOH I 5 .   ? -24.295 1.223   24.617 1.00 58.95  ? 1042 HOH A O     1 ? 
HETATM 8758 O O     . HOH I 5 .   ? -14.427 -3.272  34.029 1.00 49.65  ? 1043 HOH A O     1 ? 
HETATM 8759 O O     . HOH I 5 .   ? -22.714 6.040   10.089 1.00 51.68  ? 1044 HOH A O     1 ? 
HETATM 8760 O O     . HOH I 5 .   ? 2.774   -22.188 37.485 1.00 34.38  ? 1045 HOH A O     1 ? 
HETATM 8761 O O     . HOH I 5 .   ? 3.553   24.312  42.393 1.00 31.33  ? 1046 HOH A O     1 ? 
HETATM 8762 O O     . HOH I 5 .   ? -3.156  2.905   46.915 1.00 36.70  ? 1047 HOH A O     1 ? 
HETATM 8763 O O     . HOH I 5 .   ? -13.344 -27.984 23.535 1.00 42.32  ? 1048 HOH A O     1 ? 
HETATM 8764 O O     . HOH I 5 .   ? 4.097   -2.543  44.128 1.00 31.09  ? 1049 HOH A O     1 ? 
HETATM 8765 O O     . HOH I 5 .   ? -16.105 -8.582  29.032 1.00 40.69  ? 1050 HOH A O     1 ? 
HETATM 8766 O O     . HOH I 5 .   ? 6.469   -11.277 23.225 1.00 29.96  ? 1051 HOH A O     1 ? 
HETATM 8767 O O     . HOH I 5 .   ? 15.608  -6.245  23.933 1.00 44.76  ? 1052 HOH A O     1 ? 
HETATM 8768 O O     . HOH I 5 .   ? 15.774  -4.897  29.455 1.00 34.04  ? 1053 HOH A O     1 ? 
HETATM 8769 O O     . HOH I 5 .   ? 16.448  16.938  14.152 1.00 56.43  ? 1054 HOH A O     1 ? 
HETATM 8770 O O     . HOH I 5 .   ? 21.613  0.442   21.508 1.00 51.39  ? 1055 HOH A O     1 ? 
HETATM 8771 O O     . HOH I 5 .   ? -10.938 22.739  13.006 1.00 43.47  ? 1056 HOH A O     1 ? 
HETATM 8772 O O     . HOH I 5 .   ? 16.443  9.675   44.714 1.00 43.12  ? 1057 HOH A O     1 ? 
HETATM 8773 O O     . HOH I 5 .   ? 8.681   18.008  44.439 1.00 45.84  ? 1058 HOH A O     1 ? 
HETATM 8774 O O     . HOH I 5 .   ? -4.983  -12.093 30.974 1.00 22.42  ? 1059 HOH A O     1 ? 
HETATM 8775 O O     . HOH I 5 .   ? 6.367   -6.772  18.507 1.00 43.97  ? 1060 HOH A O     1 ? 
HETATM 8776 O O     . HOH I 5 .   ? 10.180  -12.789 11.608 1.00 35.59  ? 1061 HOH A O     1 ? 
HETATM 8777 O O     . HOH I 5 .   ? 7.291   25.104  39.969 1.00 38.59  ? 1062 HOH A O     1 ? 
HETATM 8778 O O     . HOH I 5 .   ? -7.531  -1.272  44.079 1.00 55.24  ? 1063 HOH A O     1 ? 
HETATM 8779 O O     . HOH I 5 .   ? -14.012 -6.084  37.314 1.00 48.19  ? 1064 HOH A O     1 ? 
HETATM 8780 O O     . HOH I 5 .   ? -24.294 -13.285 11.107 1.00 54.09  ? 1065 HOH A O     1 ? 
HETATM 8781 O O     . HOH I 5 .   ? 4.634   22.288  44.386 1.00 26.99  ? 1066 HOH A O     1 ? 
HETATM 8782 O O     . HOH I 5 .   ? -13.238 -25.967 27.352 1.00 42.37  ? 1067 HOH A O     1 ? 
HETATM 8783 O O     . HOH I 5 .   ? -17.654 -15.200 37.879 1.00 37.86  ? 1068 HOH A O     1 ? 
HETATM 8784 O O     . HOH I 5 .   ? -1.791  -23.521 -2.362 1.00 50.01  ? 1069 HOH A O     1 ? 
HETATM 8785 O O     . HOH I 5 .   ? 6.777   0.428   44.981 1.00 35.87  ? 1070 HOH A O     1 ? 
HETATM 8786 O O     . HOH I 5 .   ? 15.377  0.876   35.850 1.00 35.68  ? 1071 HOH A O     1 ? 
HETATM 8787 O O     . HOH I 5 .   ? -14.561 0.259   31.319 1.00 51.13  ? 1072 HOH A O     1 ? 
HETATM 8788 O O     . HOH I 5 .   ? 17.254  14.375  12.452 1.00 42.99  ? 1073 HOH A O     1 ? 
HETATM 8789 O O     . HOH I 5 .   ? -9.679  -3.526  40.480 1.00 45.68  ? 1074 HOH A O     1 ? 
HETATM 8790 O O     . HOH I 5 .   ? 9.080   20.521  45.342 1.00 42.99  ? 1075 HOH A O     1 ? 
HETATM 8791 O O     . HOH I 5 .   ? 6.166   -1.335  42.844 1.00 22.90  ? 1076 HOH A O     1 ? 
HETATM 8792 O O     . HOH I 5 .   ? 10.464  -3.760  41.353 1.00 39.93  ? 1077 HOH A O     1 ? 
HETATM 8793 O O     . HOH I 5 .   ? 14.521  -8.000  27.061 1.00 46.47  ? 1078 HOH A O     1 ? 
HETATM 8794 O O     . HOH I 5 .   ? 3.759   23.628  46.602 1.00 34.12  ? 1079 HOH A O     1 ? 
HETATM 8795 O O     . HOH I 5 .   ? 8.497   -7.980  20.135 1.00 42.47  ? 1080 HOH A O     1 ? 
HETATM 8796 O O     . HOH I 5 .   ? 8.623   -2.738  42.900 1.00 32.88  ? 1081 HOH A O     1 ? 
HETATM 8797 O O     . HOH I 5 .   ? -12.171 0.799   42.005 1.00 44.23  ? 1082 HOH A O     1 ? 
HETATM 8798 O O     . HOH J 5 .   ? -44.356 18.311  2.124  1.00 50.18  ? 701  HOH B O     1 ? 
HETATM 8799 O O     . HOH J 5 .   ? -64.636 25.453  23.436 1.00 33.04  ? 702  HOH B O     1 ? 
HETATM 8800 O O     . HOH J 5 .   ? -27.598 17.123  3.428  1.00 46.67  ? 703  HOH B O     1 ? 
HETATM 8801 O O     . HOH J 5 .   ? -42.444 60.196  7.269  1.00 45.62  ? 704  HOH B O     1 ? 
HETATM 8802 O O     . HOH J 5 .   ? -64.367 21.593  20.610 1.00 41.02  ? 705  HOH B O     1 ? 
HETATM 8803 O O     . HOH J 5 .   ? -65.124 8.343   21.085 1.00 47.86  ? 706  HOH B O     1 ? 
HETATM 8804 O O     . HOH J 5 .   ? -42.016 -0.450  42.435 1.00 41.96  ? 707  HOH B O     1 ? 
HETATM 8805 O O     . HOH J 5 .   ? -49.162 0.610   18.997 1.00 35.89  ? 708  HOH B O     1 ? 
HETATM 8806 O O     . HOH J 5 .   ? -34.336 -1.648  27.717 1.00 60.94  ? 709  HOH B O     1 ? 
HETATM 8807 O O     . HOH J 5 .   ? -19.871 28.745  24.040 1.00 45.54  ? 710  HOH B O     1 ? 
HETATM 8808 O O     . HOH J 5 .   ? -50.578 2.104   13.715 1.00 48.50  ? 711  HOH B O     1 ? 
HETATM 8809 O O     . HOH J 5 .   ? -29.151 17.748  44.641 1.00 35.47  ? 712  HOH B O     1 ? 
HETATM 8810 O O     . HOH J 5 .   ? -32.791 11.930  17.221 1.00 26.28  ? 713  HOH B O     1 ? 
HETATM 8811 O O     . HOH J 5 .   ? -55.025 35.518  0.729  1.00 35.73  ? 714  HOH B O     1 ? 
HETATM 8812 O O     . HOH J 5 .   ? -36.840 20.994  0.091  1.00 38.16  ? 715  HOH B O     1 ? 
HETATM 8813 O O     . HOH J 5 .   ? -24.139 37.860  9.136  1.00 36.09  ? 716  HOH B O     1 ? 
HETATM 8814 O O     . HOH J 5 .   ? -36.902 54.978  34.989 1.00 46.38  ? 717  HOH B O     1 ? 
HETATM 8815 O O     . HOH J 5 .   ? -24.979 28.083  6.142  1.00 39.44  ? 718  HOH B O     1 ? 
HETATM 8816 O O     . HOH J 5 .   ? -61.610 24.211  24.575 1.00 24.27  ? 719  HOH B O     1 ? 
HETATM 8817 O O     . HOH J 5 .   ? -57.291 41.736  41.757 1.00 38.07  ? 720  HOH B O     1 ? 
HETATM 8818 O O     . HOH J 5 .   ? -45.154 2.529   7.755  1.00 38.40  ? 721  HOH B O     1 ? 
HETATM 8819 O O     . HOH J 5 .   ? -41.305 1.926   34.555 1.00 32.74  ? 722  HOH B O     1 ? 
HETATM 8820 O O     . HOH J 5 .   ? -49.217 45.277  24.790 1.00 34.05  ? 723  HOH B O     1 ? 
HETATM 8821 O O     . HOH J 5 .   ? -48.513 57.735  5.826  1.00 43.42  ? 724  HOH B O     1 ? 
HETATM 8822 O O     . HOH J 5 .   ? -53.113 49.713  8.678  1.00 54.50  ? 725  HOH B O     1 ? 
HETATM 8823 O O     . HOH J 5 .   ? -49.770 52.528  27.478 1.00 31.83  ? 726  HOH B O     1 ? 
HETATM 8824 O O     . HOH J 5 .   ? -56.670 43.157  9.351  1.00 56.76  ? 727  HOH B O     1 ? 
HETATM 8825 O O     . HOH J 5 .   ? -27.553 21.943  37.718 1.00 35.99  ? 728  HOH B O     1 ? 
HETATM 8826 O O     . HOH J 5 .   ? -54.600 29.912  35.779 1.00 23.33  ? 729  HOH B O     1 ? 
HETATM 8827 O O     . HOH J 5 .   ? -61.546 23.058  41.810 1.00 31.62  ? 730  HOH B O     1 ? 
HETATM 8828 O O     . HOH J 5 .   ? -31.986 34.606  37.034 1.00 40.74  ? 731  HOH B O     1 ? 
HETATM 8829 O O     . HOH J 5 .   ? -45.256 39.960  5.591  1.00 39.10  ? 732  HOH B O     1 ? 
HETATM 8830 O O     . HOH J 5 .   ? -64.437 14.767  27.858 1.00 31.32  ? 733  HOH B O     1 ? 
HETATM 8831 O O     . HOH J 5 .   ? -27.693 44.254  28.184 1.00 33.70  ? 734  HOH B O     1 ? 
HETATM 8832 O O     . HOH J 5 .   ? -37.039 2.564   19.867 1.00 44.75  ? 735  HOH B O     1 ? 
HETATM 8833 O O     . HOH J 5 .   ? -64.129 31.007  -8.521 1.00 37.62  ? 736  HOH B O     1 ? 
HETATM 8834 O O     . HOH J 5 .   ? -33.222 33.631  7.042  1.00 33.02  ? 737  HOH B O     1 ? 
HETATM 8835 O O     . HOH J 5 .   ? -53.830 46.591  35.192 1.00 50.77  ? 738  HOH B O     1 ? 
HETATM 8836 O O     . HOH J 5 .   ? -26.720 14.857  12.233 1.00 37.46  ? 739  HOH B O     1 ? 
HETATM 8837 O O     . HOH J 5 .   ? -42.891 -4.617  22.303 1.00 52.80  ? 740  HOH B O     1 ? 
HETATM 8838 O O     . HOH J 5 .   ? -28.673 10.913  37.374 1.00 51.76  ? 741  HOH B O     1 ? 
HETATM 8839 O O     . HOH J 5 .   ? -56.040 10.767  16.121 1.00 34.81  ? 742  HOH B O     1 ? 
HETATM 8840 O O     . HOH J 5 .   ? -57.291 33.363  29.916 1.00 27.64  ? 743  HOH B O     1 ? 
HETATM 8841 O O     . HOH J 5 .   ? -22.686 31.890  8.449  1.00 46.36  ? 744  HOH B O     1 ? 
HETATM 8842 O O     . HOH J 5 .   ? -43.764 61.052  18.712 1.00 36.65  ? 745  HOH B O     1 ? 
HETATM 8843 O O     . HOH J 5 .   ? -40.051 16.198  6.045  1.00 36.93  ? 746  HOH B O     1 ? 
HETATM 8844 O O     . HOH J 5 .   ? -42.375 22.944  7.634  1.00 29.65  ? 747  HOH B O     1 ? 
HETATM 8845 O O     . HOH J 5 .   ? -43.594 -4.074  18.257 1.00 42.71  ? 748  HOH B O     1 ? 
HETATM 8846 O O     . HOH J 5 .   ? -49.323 52.631  1.803  1.00 41.90  ? 749  HOH B O     1 ? 
HETATM 8847 O O     . HOH J 5 .   ? -39.761 55.095  19.871 1.00 28.78  ? 750  HOH B O     1 ? 
HETATM 8848 O O     . HOH J 5 .   ? -27.044 48.492  27.073 1.00 33.79  ? 751  HOH B O     1 ? 
HETATM 8849 O O     . HOH J 5 .   ? -47.189 57.744  25.154 1.00 42.32  ? 752  HOH B O     1 ? 
HETATM 8850 O O     . HOH J 5 .   ? -29.244 34.804  5.000  1.00 41.58  ? 753  HOH B O     1 ? 
HETATM 8851 O O     . HOH J 5 .   ? -53.710 7.574   42.061 1.00 45.43  ? 754  HOH B O     1 ? 
HETATM 8852 O O     . HOH J 5 .   ? -34.791 32.496  10.784 1.00 29.35  ? 755  HOH B O     1 ? 
HETATM 8853 O O     . HOH J 5 .   ? -51.861 24.731  12.509 1.00 24.28  ? 756  HOH B O     1 ? 
HETATM 8854 O O     . HOH J 5 .   ? -46.263 26.605  24.471 1.00 24.05  ? 757  HOH B O     1 ? 
HETATM 8855 O O     . HOH J 5 .   ? -49.806 23.151  25.271 1.00 17.65  ? 758  HOH B O     1 ? 
HETATM 8856 O O     . HOH J 5 .   ? -55.974 5.748   38.228 1.00 29.70  ? 759  HOH B O     1 ? 
HETATM 8857 O O     . HOH J 5 .   ? -45.295 31.549  45.909 1.00 39.39  ? 760  HOH B O     1 ? 
HETATM 8858 O O     . HOH J 5 .   ? -52.135 1.352   38.778 1.00 41.28  ? 761  HOH B O     1 ? 
HETATM 8859 O O     . HOH J 5 .   ? -45.320 52.965  35.558 1.00 27.23  ? 762  HOH B O     1 ? 
HETATM 8860 O O     . HOH J 5 .   ? -48.074 14.584  7.628  1.00 44.91  ? 763  HOH B O     1 ? 
HETATM 8861 O O     . HOH J 5 .   ? -55.503 15.080  41.366 1.00 24.77  ? 764  HOH B O     1 ? 
HETATM 8862 O O     . HOH J 5 .   ? -55.686 37.736  30.092 1.00 32.65  ? 765  HOH B O     1 ? 
HETATM 8863 O O     . HOH J 5 .   ? -51.149 38.982  9.202  1.00 27.56  ? 766  HOH B O     1 ? 
HETATM 8864 O O     . HOH J 5 .   ? -48.285 38.730  24.137 1.00 21.95  ? 767  HOH B O     1 ? 
HETATM 8865 O O     . HOH J 5 .   ? -49.599 9.313   41.163 1.00 39.28  ? 768  HOH B O     1 ? 
HETATM 8866 O O     . HOH J 5 .   ? -50.172 17.180  12.432 1.00 22.87  ? 769  HOH B O     1 ? 
HETATM 8867 O O     . HOH J 5 .   ? -43.391 36.706  8.818  1.00 32.17  ? 770  HOH B O     1 ? 
HETATM 8868 O O     . HOH J 5 .   ? -57.737 20.400  19.102 1.00 23.22  ? 771  HOH B O     1 ? 
HETATM 8869 O O     . HOH J 5 .   ? -47.463 30.922  26.005 1.00 26.89  ? 772  HOH B O     1 ? 
HETATM 8870 O O     . HOH J 5 .   ? -26.443 54.414  15.390 1.00 44.02  ? 773  HOH B O     1 ? 
HETATM 8871 O O     . HOH J 5 .   ? -37.512 23.719  37.430 1.00 21.39  ? 774  HOH B O     1 ? 
HETATM 8872 O O     . HOH J 5 .   ? -45.909 49.468  22.363 1.00 25.80  ? 775  HOH B O     1 ? 
HETATM 8873 O O     . HOH J 5 .   ? -35.631 27.519  2.461  1.00 29.28  ? 776  HOH B O     1 ? 
HETATM 8874 O O     . HOH J 5 .   ? -39.303 9.146   9.470  1.00 35.57  ? 777  HOH B O     1 ? 
HETATM 8875 O O     . HOH J 5 .   ? -42.411 -0.152  12.631 1.00 46.29  ? 778  HOH B O     1 ? 
HETATM 8876 O O     . HOH J 5 .   ? -39.872 36.096  0.983  1.00 38.45  ? 779  HOH B O     1 ? 
HETATM 8877 O O     . HOH J 5 .   ? -35.186 24.555  39.021 1.00 26.93  ? 780  HOH B O     1 ? 
HETATM 8878 O O     . HOH J 5 .   ? -53.531 23.143  53.535 1.00 32.34  ? 781  HOH B O     1 ? 
HETATM 8879 O O     . HOH J 5 .   ? -21.424 15.120  42.661 1.00 46.81  ? 782  HOH B O     1 ? 
HETATM 8880 O O     . HOH J 5 .   ? -33.877 29.894  38.592 1.00 39.03  ? 783  HOH B O     1 ? 
HETATM 8881 O O     . HOH J 5 .   ? -50.257 5.341   14.524 1.00 37.88  ? 784  HOH B O     1 ? 
HETATM 8882 O O     . HOH J 5 .   ? -55.030 39.882  43.615 1.00 43.52  ? 785  HOH B O     1 ? 
HETATM 8883 O O     . HOH J 5 .   ? -43.650 17.024  56.195 1.00 48.68  ? 786  HOH B O     1 ? 
HETATM 8884 O O     . HOH J 5 .   ? -29.299 26.701  35.818 1.00 39.10  ? 787  HOH B O     1 ? 
HETATM 8885 O O     . HOH J 5 .   ? -63.375 26.198  19.166 1.00 38.57  ? 788  HOH B O     1 ? 
HETATM 8886 O O     . HOH J 5 .   ? -43.302 58.780  24.806 1.00 37.56  ? 789  HOH B O     1 ? 
HETATM 8887 O O     . HOH J 5 .   ? -55.590 -0.439  36.476 1.00 39.16  ? 790  HOH B O     1 ? 
HETATM 8888 O O     . HOH J 5 .   ? -56.895 12.113  39.083 1.00 27.29  ? 791  HOH B O     1 ? 
HETATM 8889 O O     . HOH J 5 .   ? -55.929 5.391   18.241 1.00 41.70  ? 792  HOH B O     1 ? 
HETATM 8890 O O     . HOH J 5 .   ? -39.781 30.844  43.918 1.00 39.30  ? 793  HOH B O     1 ? 
HETATM 8891 O O     . HOH J 5 .   ? -38.533 9.060   45.372 1.00 43.26  ? 794  HOH B O     1 ? 
HETATM 8892 O O     . HOH J 5 .   ? -41.583 14.471  6.669  1.00 35.88  ? 795  HOH B O     1 ? 
HETATM 8893 O O     . HOH J 5 .   ? -47.124 34.408  31.066 1.00 20.45  ? 796  HOH B O     1 ? 
HETATM 8894 O O     . HOH J 5 .   ? -49.203 -1.652  27.852 1.00 35.81  ? 797  HOH B O     1 ? 
HETATM 8895 O O     . HOH J 5 .   ? -50.597 37.598  25.062 1.00 25.03  ? 798  HOH B O     1 ? 
HETATM 8896 O O     . HOH J 5 .   ? -37.072 44.772  36.502 1.00 27.31  ? 799  HOH B O     1 ? 
HETATM 8897 O O     . HOH J 5 .   ? -44.373 25.174  45.584 1.00 27.03  ? 800  HOH B O     1 ? 
HETATM 8898 O O     . HOH J 5 .   ? -45.331 36.709  6.323  1.00 43.22  ? 801  HOH B O     1 ? 
HETATM 8899 O O     . HOH J 5 .   ? -27.559 36.382  17.644 1.00 39.77  ? 802  HOH B O     1 ? 
HETATM 8900 O O     . HOH J 5 .   ? -20.165 22.910  21.995 1.00 37.49  ? 803  HOH B O     1 ? 
HETATM 8901 O O     . HOH J 5 .   ? -49.765 19.623  13.635 1.00 22.81  ? 804  HOH B O     1 ? 
HETATM 8902 O O     . HOH J 5 .   ? -45.729 29.226  24.432 1.00 24.33  ? 805  HOH B O     1 ? 
HETATM 8903 O O     . HOH J 5 .   ? -31.901 27.950  11.407 1.00 30.41  ? 806  HOH B O     1 ? 
HETATM 8904 O O     . HOH J 5 .   ? -32.010 51.634  2.078  1.00 38.90  ? 807  HOH B O     1 ? 
HETATM 8905 O O     . HOH J 5 .   ? -63.674 21.134  37.489 1.00 36.98  ? 808  HOH B O     1 ? 
HETATM 8906 O O     . HOH J 5 .   ? -44.853 18.029  23.137 1.00 16.97  ? 809  HOH B O     1 ? 
HETATM 8907 O O     . HOH J 5 .   ? -34.151 13.822  9.422  1.00 39.55  ? 810  HOH B O     1 ? 
HETATM 8908 O O     . HOH J 5 .   ? -44.590 41.052  37.754 1.00 21.82  ? 811  HOH B O     1 ? 
HETATM 8909 O O     . HOH J 5 .   ? -41.976 20.353  7.138  1.00 30.00  ? 812  HOH B O     1 ? 
HETATM 8910 O O     . HOH J 5 .   ? -37.994 1.202   41.014 1.00 45.04  ? 813  HOH B O     1 ? 
HETATM 8911 O O     . HOH J 5 .   ? -52.529 31.803  36.083 1.00 16.75  ? 814  HOH B O     1 ? 
HETATM 8912 O O     . HOH J 5 .   ? -60.646 9.958   21.467 1.00 31.22  ? 815  HOH B O     1 ? 
HETATM 8913 O O     . HOH J 5 .   ? -47.194 52.378  33.754 1.00 30.87  ? 816  HOH B O     1 ? 
HETATM 8914 O O     . HOH J 5 .   ? -51.203 6.129   7.941  1.00 37.20  ? 817  HOH B O     1 ? 
HETATM 8915 O O     . HOH J 5 .   ? -57.528 20.879  45.937 1.00 30.39  ? 818  HOH B O     1 ? 
HETATM 8916 O O     . HOH J 5 .   ? -35.390 19.556  42.577 1.00 23.44  ? 819  HOH B O     1 ? 
HETATM 8917 O O     . HOH J 5 .   ? -52.376 48.885  13.109 1.00 36.17  ? 820  HOH B O     1 ? 
HETATM 8918 O O     . HOH J 5 .   ? -23.890 14.794  38.078 1.00 46.18  ? 821  HOH B O     1 ? 
HETATM 8919 O O     . HOH J 5 .   ? -51.436 11.841  43.353 1.00 28.81  ? 822  HOH B O     1 ? 
HETATM 8920 O O     . HOH J 5 .   ? -55.137 14.090  38.866 1.00 30.41  ? 823  HOH B O     1 ? 
HETATM 8921 O O     . HOH J 5 .   ? -34.139 42.893  41.932 1.00 37.31  ? 824  HOH B O     1 ? 
HETATM 8922 O O     . HOH J 5 .   ? -57.174 27.416  38.324 1.00 26.87  ? 825  HOH B O     1 ? 
HETATM 8923 O O     . HOH J 5 .   ? -58.677 19.380  16.500 1.00 31.91  ? 826  HOH B O     1 ? 
HETATM 8924 O O     . HOH J 5 .   ? -68.447 8.700   32.448 1.00 28.04  ? 827  HOH B O     1 ? 
HETATM 8925 O O     . HOH J 5 .   ? -27.300 15.583  34.938 1.00 34.38  ? 828  HOH B O     1 ? 
HETATM 8926 O O     . HOH J 5 .   ? -45.232 19.959  16.177 1.00 20.16  ? 829  HOH B O     1 ? 
HETATM 8927 O O     . HOH J 5 .   ? -39.231 20.626  48.654 1.00 32.80  ? 830  HOH B O     1 ? 
HETATM 8928 O O     . HOH J 5 .   ? -31.674 51.967  32.584 1.00 30.50  ? 831  HOH B O     1 ? 
HETATM 8929 O O     . HOH J 5 .   ? -27.440 28.759  16.074 1.00 27.80  ? 832  HOH B O     1 ? 
HETATM 8930 O O     . HOH J 5 .   ? -54.556 21.266  32.288 1.00 32.77  ? 833  HOH B O     1 ? 
HETATM 8931 O O     . HOH J 5 .   ? -50.278 38.048  41.444 1.00 34.91  ? 834  HOH B O     1 ? 
HETATM 8932 O O     . HOH J 5 .   ? -39.524 24.607  45.814 1.00 24.58  ? 835  HOH B O     1 ? 
HETATM 8933 O O     . HOH J 5 .   ? -37.012 8.250   35.824 1.00 30.23  ? 836  HOH B O     1 ? 
HETATM 8934 O O     . HOH J 5 .   ? -46.810 50.809  6.255  1.00 27.80  ? 837  HOH B O     1 ? 
HETATM 8935 O O     . HOH J 5 .   ? -28.990 52.723  25.409 1.00 28.69  ? 838  HOH B O     1 ? 
HETATM 8936 O O     . HOH J 5 .   ? -59.234 16.024  26.017 1.00 29.86  ? 839  HOH B O     1 ? 
HETATM 8937 O O     . HOH J 5 .   ? -52.696 28.520  27.443 1.00 16.14  ? 840  HOH B O     1 ? 
HETATM 8938 O O     . HOH J 5 .   ? -26.260 21.918  11.531 1.00 36.49  ? 841  HOH B O     1 ? 
HETATM 8939 O O     . HOH J 5 .   ? -42.909 26.927  25.631 1.00 18.62  ? 842  HOH B O     1 ? 
HETATM 8940 O O     . HOH J 5 .   ? -37.324 29.103  17.009 1.00 21.62  ? 843  HOH B O     1 ? 
HETATM 8941 O O     . HOH J 5 .   ? -30.539 40.195  27.594 1.00 26.26  ? 844  HOH B O     1 ? 
HETATM 8942 O O     . HOH J 5 .   ? -42.957 25.131  42.514 1.00 23.67  ? 845  HOH B O     1 ? 
HETATM 8943 O O     . HOH J 5 .   ? -25.127 45.321  18.149 1.00 36.08  ? 846  HOH B O     1 ? 
HETATM 8944 O O     . HOH J 5 .   ? -41.021 45.697  38.699 1.00 24.62  ? 847  HOH B O     1 ? 
HETATM 8945 O O     . HOH J 5 .   ? -27.191 35.068  29.618 1.00 40.28  ? 848  HOH B O     1 ? 
HETATM 8946 O O     . HOH J 5 .   ? -37.603 44.920  40.006 1.00 33.70  ? 849  HOH B O     1 ? 
HETATM 8947 O O     . HOH J 5 .   ? -59.228 26.594  35.895 1.00 29.77  ? 850  HOH B O     1 ? 
HETATM 8948 O O     . HOH J 5 .   ? -42.216 45.038  15.253 1.00 26.02  ? 851  HOH B O     1 ? 
HETATM 8949 O O     . HOH J 5 .   ? -35.319 14.147  6.737  1.00 37.58  ? 852  HOH B O     1 ? 
HETATM 8950 O O     . HOH J 5 .   ? -49.917 5.292   41.456 1.00 33.46  ? 853  HOH B O     1 ? 
HETATM 8951 O O     . HOH J 5 .   ? -33.945 9.026   38.340 1.00 29.55  ? 854  HOH B O     1 ? 
HETATM 8952 O O     . HOH J 5 .   ? -60.441 3.879   24.551 1.00 34.26  ? 855  HOH B O     1 ? 
HETATM 8953 O O     . HOH J 5 .   ? -33.062 33.168  4.450  1.00 37.13  ? 856  HOH B O     1 ? 
HETATM 8954 O O     . HOH J 5 .   ? -59.690 26.757  27.118 1.00 23.12  ? 857  HOH B O     1 ? 
HETATM 8955 O O     . HOH J 5 .   ? -53.898 41.767  29.785 1.00 43.39  ? 858  HOH B O     1 ? 
HETATM 8956 O O     . HOH J 5 .   ? -27.950 42.000  29.448 1.00 50.00  ? 859  HOH B O     1 ? 
HETATM 8957 O O     . HOH J 5 .   ? -29.689 7.314   32.875 1.00 48.20  ? 860  HOH B O     1 ? 
HETATM 8958 O O     . HOH J 5 .   ? -61.524 31.301  14.815 1.00 32.74  ? 861  HOH B O     1 ? 
HETATM 8959 O O     . HOH J 5 .   ? -37.056 36.833  39.982 1.00 28.17  ? 862  HOH B O     1 ? 
HETATM 8960 O O     . HOH J 5 .   ? -41.564 11.578  8.996  1.00 41.37  ? 863  HOH B O     1 ? 
HETATM 8961 O O     . HOH J 5 .   ? -52.923 16.433  12.689 1.00 22.29  ? 864  HOH B O     1 ? 
HETATM 8962 O O     . HOH J 5 .   ? -61.265 23.537  33.417 1.00 22.15  ? 865  HOH B O     1 ? 
HETATM 8963 O O     . HOH J 5 .   ? -47.363 45.664  12.853 1.00 42.04  ? 866  HOH B O     1 ? 
HETATM 8964 O O     . HOH J 5 .   ? -45.169 44.076  21.683 1.00 41.50  ? 867  HOH B O     1 ? 
HETATM 8965 O O     . HOH J 5 .   ? -44.279 46.186  -4.255 1.00 55.66  ? 868  HOH B O     1 ? 
HETATM 8966 O O     . HOH J 5 .   ? -49.022 21.544  5.597  1.00 33.52  ? 869  HOH B O     1 ? 
HETATM 8967 O O     . HOH J 5 .   ? -27.810 22.447  24.735 1.00 24.95  ? 870  HOH B O     1 ? 
HETATM 8968 O O     . HOH J 5 .   ? -48.049 23.312  28.785 1.00 20.92  ? 871  HOH B O     1 ? 
HETATM 8969 O O     . HOH J 5 .   ? -49.810 25.916  45.295 1.00 30.90  ? 872  HOH B O     1 ? 
HETATM 8970 O O     . HOH J 5 .   ? -37.329 36.058  21.205 1.00 29.03  ? 873  HOH B O     1 ? 
HETATM 8971 O O     . HOH J 5 .   ? -54.028 23.831  39.055 1.00 20.33  ? 874  HOH B O     1 ? 
HETATM 8972 O O     . HOH J 5 .   ? -63.082 24.220  39.345 1.00 50.01  ? 875  HOH B O     1 ? 
HETATM 8973 O O     . HOH J 5 .   ? -36.529 61.382  1.690  1.00 48.28  ? 876  HOH B O     1 ? 
HETATM 8974 O O     . HOH J 5 .   ? -46.724 33.565  9.927  1.00 25.34  ? 877  HOH B O     1 ? 
HETATM 8975 O O     . HOH J 5 .   ? -30.024 17.861  6.188  1.00 35.32  ? 878  HOH B O     1 ? 
HETATM 8976 O O     . HOH J 5 .   ? -39.384 8.146   11.976 1.00 31.01  ? 879  HOH B O     1 ? 
HETATM 8977 O O     . HOH J 5 .   ? -57.610 24.672  46.128 1.00 35.38  ? 880  HOH B O     1 ? 
HETATM 8978 O O     . HOH J 5 .   ? -31.148 54.268  31.194 1.00 35.54  ? 881  HOH B O     1 ? 
HETATM 8979 O O     . HOH J 5 .   ? -38.573 40.110  33.276 1.00 20.43  ? 882  HOH B O     1 ? 
HETATM 8980 O O     . HOH J 5 .   ? -53.908 37.357  39.976 1.00 29.47  ? 883  HOH B O     1 ? 
HETATM 8981 O O     . HOH J 5 .   ? -23.865 42.860  5.813  1.00 38.65  ? 884  HOH B O     1 ? 
HETATM 8982 O O     . HOH J 5 .   ? -23.676 34.700  9.658  1.00 36.54  ? 885  HOH B O     1 ? 
HETATM 8983 O O     . HOH J 5 .   ? -60.404 26.103  16.471 1.00 32.11  ? 886  HOH B O     1 ? 
HETATM 8984 O O     . HOH J 5 .   ? -41.748 26.007  45.739 1.00 34.78  ? 887  HOH B O     1 ? 
HETATM 8985 O O     . HOH J 5 .   ? -36.826 27.925  43.569 1.00 49.12  ? 888  HOH B O     1 ? 
HETATM 8986 O O     . HOH J 5 .   ? -61.074 13.480  26.708 1.00 34.81  ? 889  HOH B O     1 ? 
HETATM 8987 O O     . HOH J 5 .   ? -58.206 28.248  30.518 1.00 26.87  ? 890  HOH B O     1 ? 
HETATM 8988 O O     . HOH J 5 .   ? -48.820 51.355  -1.827 1.00 31.68  ? 891  HOH B O     1 ? 
HETATM 8989 O O     . HOH J 5 .   ? -38.654 30.069  40.756 1.00 26.13  ? 892  HOH B O     1 ? 
HETATM 8990 O O     . HOH J 5 .   ? -62.205 28.235  23.772 1.00 30.87  ? 893  HOH B O     1 ? 
HETATM 8991 O O     . HOH J 5 .   ? -29.976 30.709  26.510 1.00 41.33  ? 894  HOH B O     1 ? 
HETATM 8992 O O     . HOH J 5 .   ? -62.135 22.804  36.299 1.00 31.44  ? 895  HOH B O     1 ? 
HETATM 8993 O O     . HOH J 5 .   ? -40.462 61.574  18.762 1.00 33.85  ? 896  HOH B O     1 ? 
HETATM 8994 O O     . HOH J 5 .   ? -46.772 24.754  26.232 1.00 21.20  ? 897  HOH B O     1 ? 
HETATM 8995 O O     . HOH J 5 .   ? -38.865 11.961  48.210 1.00 32.43  ? 898  HOH B O     1 ? 
HETATM 8996 O O     . HOH J 5 .   ? -46.468 32.302  42.186 1.00 26.49  ? 899  HOH B O     1 ? 
HETATM 8997 O O     . HOH J 5 .   ? -33.475 18.303  46.030 1.00 42.31  ? 900  HOH B O     1 ? 
HETATM 8998 O O     . HOH J 5 .   ? -32.763 29.920  13.275 1.00 21.80  ? 901  HOH B O     1 ? 
HETATM 8999 O O     . HOH J 5 .   ? -30.780 32.132  15.872 1.00 42.77  ? 902  HOH B O     1 ? 
HETATM 9000 O O     . HOH J 5 .   ? -49.658 45.391  11.057 1.00 46.12  ? 903  HOH B O     1 ? 
HETATM 9001 O O     . HOH J 5 .   ? -52.259 -0.435  29.286 1.00 27.42  ? 904  HOH B O     1 ? 
HETATM 9002 O O     . HOH J 5 .   ? -57.435 0.685   29.811 1.00 43.69  ? 905  HOH B O     1 ? 
HETATM 9003 O O     . HOH J 5 .   ? -37.609 39.426  28.586 1.00 26.25  ? 906  HOH B O     1 ? 
HETATM 9004 O O     . HOH J 5 .   ? -49.886 44.318  -0.044 1.00 39.91  ? 907  HOH B O     1 ? 
HETATM 9005 O O     . HOH J 5 .   ? -32.179 29.458  34.640 1.00 26.52  ? 908  HOH B O     1 ? 
HETATM 9006 O O     . HOH J 5 .   ? -43.030 -0.026  34.042 1.00 38.67  ? 909  HOH B O     1 ? 
HETATM 9007 O O     . HOH J 5 .   ? -57.768 41.701  1.659  1.00 42.61  ? 910  HOH B O     1 ? 
HETATM 9008 O O     . HOH J 5 .   ? -55.336 34.965  35.746 1.00 40.19  ? 911  HOH B O     1 ? 
HETATM 9009 O O     . HOH J 5 .   ? -54.912 21.223  39.380 1.00 18.81  ? 912  HOH B O     1 ? 
HETATM 9010 O O     . HOH J 5 .   ? -45.933 38.663  39.736 1.00 39.10  ? 913  HOH B O     1 ? 
HETATM 9011 O O     . HOH J 5 .   ? -43.777 -6.697  26.821 1.00 53.50  ? 914  HOH B O     1 ? 
HETATM 9012 O O     . HOH J 5 .   ? -52.731 5.397   15.910 1.00 37.12  ? 915  HOH B O     1 ? 
HETATM 9013 O O     . HOH J 5 .   ? -53.497 15.050  43.277 1.00 27.14  ? 916  HOH B O     1 ? 
HETATM 9014 O O     . HOH J 5 .   ? -41.874 37.551  -0.133 1.00 38.61  ? 917  HOH B O     1 ? 
HETATM 9015 O O     . HOH J 5 .   ? -34.463 60.393  31.046 1.00 36.37  ? 918  HOH B O     1 ? 
HETATM 9016 O O     . HOH J 5 .   ? -57.734 54.633  11.195 1.00 48.89  ? 919  HOH B O     1 ? 
HETATM 9017 O O     . HOH J 5 .   ? -58.248 1.041   32.648 1.00 29.60  ? 920  HOH B O     1 ? 
HETATM 9018 O O     . HOH J 5 .   ? -55.614 21.407  8.682  1.00 43.71  ? 921  HOH B O     1 ? 
HETATM 9019 O O     . HOH J 5 .   ? -62.316 5.752   27.808 1.00 22.73  ? 922  HOH B O     1 ? 
HETATM 9020 O O     . HOH J 5 .   ? -42.689 31.364  4.991  1.00 36.86  ? 923  HOH B O     1 ? 
HETATM 9021 O O     . HOH J 5 .   ? -39.223 35.358  33.866 1.00 33.03  ? 924  HOH B O     1 ? 
HETATM 9022 O O     . HOH J 5 .   ? -33.051 29.218  9.308  1.00 32.24  ? 925  HOH B O     1 ? 
HETATM 9023 O O     . HOH J 5 .   ? -41.044 21.772  50.092 1.00 36.73  ? 926  HOH B O     1 ? 
HETATM 9024 O O     . HOH J 5 .   ? -45.969 -1.883  10.885 1.00 43.56  ? 927  HOH B O     1 ? 
HETATM 9025 O O     . HOH J 5 .   ? -43.970 24.342  26.367 1.00 17.37  ? 928  HOH B O     1 ? 
HETATM 9026 O O     . HOH J 5 .   ? -60.662 23.775  8.118  1.00 38.16  ? 929  HOH B O     1 ? 
HETATM 9027 O O     . HOH J 5 .   ? -31.281 28.352  26.035 1.00 34.67  ? 930  HOH B O     1 ? 
HETATM 9028 O O     . HOH J 5 .   ? -21.532 19.000  15.235 1.00 39.89  ? 931  HOH B O     1 ? 
HETATM 9029 O O     . HOH J 5 .   ? -32.751 9.601   41.147 1.00 43.42  ? 932  HOH B O     1 ? 
HETATM 9030 O O     . HOH J 5 .   ? -46.440 -0.992  33.721 1.00 37.52  ? 933  HOH B O     1 ? 
HETATM 9031 O O     . HOH J 5 .   ? -60.985 17.922  17.596 1.00 42.96  ? 934  HOH B O     1 ? 
HETATM 9032 O O     . HOH J 5 .   ? -48.547 31.028  40.542 1.00 22.93  ? 935  HOH B O     1 ? 
HETATM 9033 O O     . HOH J 5 .   ? -29.502 9.629   16.781 1.00 46.67  ? 936  HOH B O     1 ? 
HETATM 9034 O O     . HOH J 5 .   ? -44.850 33.894  5.181  1.00 33.78  ? 937  HOH B O     1 ? 
HETATM 9035 O O     . HOH J 5 .   ? -55.089 42.406  32.581 1.00 29.46  ? 938  HOH B O     1 ? 
HETATM 9036 O O     . HOH J 5 .   ? -48.792 51.138  8.405  1.00 34.07  ? 939  HOH B O     1 ? 
HETATM 9037 O O     . HOH J 5 .   ? -28.530 6.905   27.223 1.00 47.57  ? 940  HOH B O     1 ? 
HETATM 9038 O O     . HOH J 5 .   ? -32.727 11.531  37.828 1.00 27.53  ? 941  HOH B O     1 ? 
HETATM 9039 O O     . HOH J 5 .   ? -52.420 39.892  27.734 1.00 25.82  ? 942  HOH B O     1 ? 
HETATM 9040 O O     . HOH J 5 .   ? -45.558 46.382  23.274 1.00 21.86  ? 943  HOH B O     1 ? 
HETATM 9041 O O     . HOH J 5 .   ? -20.185 25.349  6.457  1.00 51.63  ? 944  HOH B O     1 ? 
HETATM 9042 O O     . HOH J 5 .   ? -52.430 18.791  32.457 1.00 32.53  ? 945  HOH B O     1 ? 
HETATM 9043 O O     . HOH J 5 .   ? -30.091 34.529  17.338 1.00 37.92  ? 946  HOH B O     1 ? 
HETATM 9044 O O     . HOH J 5 .   ? -35.733 6.381   43.921 1.00 42.95  ? 947  HOH B O     1 ? 
HETATM 9045 O O     . HOH J 5 .   ? -50.384 48.341  11.415 1.00 32.91  ? 948  HOH B O     1 ? 
HETATM 9046 O O     . HOH J 5 .   ? -61.501 28.749  13.758 1.00 27.19  ? 949  HOH B O     1 ? 
HETATM 9047 O O     . HOH J 5 .   ? -48.058 12.388  5.555  1.00 41.12  ? 950  HOH B O     1 ? 
HETATM 9048 O O     . HOH J 5 .   ? -61.496 33.210  19.769 1.00 37.45  ? 951  HOH B O     1 ? 
HETATM 9049 O O     . HOH J 5 .   ? -55.223 8.469   15.838 1.00 41.03  ? 952  HOH B O     1 ? 
HETATM 9050 O O     . HOH J 5 .   ? -49.168 14.708  11.987 1.00 31.24  ? 953  HOH B O     1 ? 
HETATM 9051 O O     . HOH J 5 .   ? -55.612 30.966  33.350 1.00 17.16  ? 954  HOH B O     1 ? 
HETATM 9052 O O     . HOH J 5 .   ? -55.874 43.675  1.420  1.00 39.79  ? 955  HOH B O     1 ? 
HETATM 9053 O O     . HOH J 5 .   ? -60.456 26.583  24.576 1.00 24.03  ? 956  HOH B O     1 ? 
HETATM 9054 O O     . HOH J 5 .   ? -50.508 23.803  27.705 1.00 17.11  ? 957  HOH B O     1 ? 
HETATM 9055 O O     . HOH J 5 .   ? -52.080 27.851  45.119 1.00 39.33  ? 958  HOH B O     1 ? 
HETATM 9056 O O     . HOH J 5 .   ? -38.268 46.950  37.914 1.00 23.63  ? 959  HOH B O     1 ? 
HETATM 9057 O O     . HOH J 5 .   ? -25.162 35.300  5.995  1.00 38.82  ? 960  HOH B O     1 ? 
HETATM 9058 O O     . HOH J 5 .   ? -27.890 22.629  45.754 1.00 39.83  ? 961  HOH B O     1 ? 
HETATM 9059 O O     . HOH J 5 .   ? -23.735 42.450  27.095 1.00 46.42  ? 962  HOH B O     1 ? 
HETATM 9060 O O     . HOH J 5 .   ? -36.764 52.633  37.960 1.00 54.61  ? 963  HOH B O     1 ? 
HETATM 9061 O O     . HOH J 5 .   ? -56.761 19.518  48.366 1.00 44.60  ? 964  HOH B O     1 ? 
HETATM 9062 O O     . HOH J 5 .   ? -36.473 -2.440  13.691 1.00 45.74  ? 965  HOH B O     1 ? 
HETATM 9063 O O     . HOH J 5 .   ? -46.762 32.861  27.634 1.00 20.30  ? 966  HOH B O     1 ? 
HETATM 9064 O O     . HOH J 5 .   ? -47.931 46.472  17.309 1.00 38.91  ? 967  HOH B O     1 ? 
HETATM 9065 O O     . HOH J 5 .   ? -29.455 8.751   34.524 1.00 46.99  ? 968  HOH B O     1 ? 
HETATM 9066 O O     . HOH J 5 .   ? -23.852 31.419  17.412 1.00 33.22  ? 969  HOH B O     1 ? 
HETATM 9067 O O     . HOH J 5 .   ? -36.300 0.620   24.157 1.00 46.48  ? 970  HOH B O     1 ? 
HETATM 9068 O O     . HOH J 5 .   ? -49.415 10.721  44.395 1.00 40.65  ? 971  HOH B O     1 ? 
HETATM 9069 O O     . HOH J 5 .   ? -28.751 38.086  32.310 1.00 38.01  ? 972  HOH B O     1 ? 
HETATM 9070 O O     . HOH J 5 .   ? -57.741 8.801   18.745 1.00 40.67  ? 973  HOH B O     1 ? 
HETATM 9071 O O     . HOH J 5 .   ? -48.776 -5.840  21.846 1.00 50.37  ? 974  HOH B O     1 ? 
HETATM 9072 O O     . HOH J 5 .   ? -26.982 47.791  31.635 1.00 41.49  ? 975  HOH B O     1 ? 
HETATM 9073 O O     . HOH J 5 .   ? -49.229 56.294  24.701 1.00 34.28  ? 976  HOH B O     1 ? 
HETATM 9074 O O     . HOH J 5 .   ? -28.148 31.143  29.017 1.00 43.26  ? 977  HOH B O     1 ? 
HETATM 9075 O O     . HOH J 5 .   ? -37.111 30.263  1.285  1.00 29.23  ? 978  HOH B O     1 ? 
HETATM 9076 O O     . HOH J 5 .   ? -27.667 25.972  38.839 1.00 48.26  ? 979  HOH B O     1 ? 
HETATM 9077 O O     . HOH J 5 .   ? -35.481 15.357  49.708 1.00 52.88  ? 980  HOH B O     1 ? 
HETATM 9078 O O     . HOH J 5 .   ? -39.120 37.658  32.287 1.00 21.56  ? 981  HOH B O     1 ? 
HETATM 9079 O O     . HOH J 5 .   ? -45.506 32.720  30.135 1.00 20.81  ? 982  HOH B O     1 ? 
HETATM 9080 O O     . HOH J 5 .   ? -54.011 17.191  34.232 1.00 30.60  ? 983  HOH B O     1 ? 
HETATM 9081 O O     . HOH J 5 .   ? -61.616 30.282  27.337 1.00 38.56  ? 984  HOH B O     1 ? 
HETATM 9082 O O     . HOH J 5 .   ? -50.808 41.712  27.216 1.00 29.36  ? 985  HOH B O     1 ? 
HETATM 9083 O O     . HOH J 5 .   ? -44.048 29.147  2.198  1.00 35.79  ? 986  HOH B O     1 ? 
HETATM 9084 O O     . HOH J 5 .   ? -23.200 51.990  20.529 1.00 58.03  ? 987  HOH B O     1 ? 
HETATM 9085 O O     . HOH J 5 .   ? -59.592 15.064  15.614 1.00 36.15  ? 988  HOH B O     1 ? 
HETATM 9086 O O     . HOH J 5 .   ? -27.005 0.216   25.158 1.00 47.63  ? 989  HOH B O     1 ? 
HETATM 9087 O O     . HOH J 5 .   ? -26.965 56.594  8.037  1.00 43.40  ? 990  HOH B O     1 ? 
HETATM 9088 O O     . HOH J 5 .   ? -41.655 51.415  -0.078 1.00 38.68  ? 991  HOH B O     1 ? 
HETATM 9089 O O     . HOH J 5 .   ? -52.607 43.572  29.021 1.00 35.00  ? 992  HOH B O     1 ? 
HETATM 9090 O O     . HOH J 5 .   ? -59.210 33.669  25.230 1.00 46.17  ? 993  HOH B O     1 ? 
HETATM 9091 O O     . HOH J 5 .   ? -53.782 16.582  10.287 1.00 46.33  ? 994  HOH B O     1 ? 
HETATM 9092 O O     . HOH J 5 .   ? -46.813 -6.268  20.213 1.00 50.87  ? 995  HOH B O     1 ? 
HETATM 9093 O O     . HOH J 5 .   ? -20.670 16.062  24.116 1.00 45.62  ? 996  HOH B O     1 ? 
HETATM 9094 O O     . HOH J 5 .   ? -32.600 33.710  31.041 1.00 41.74  ? 997  HOH B O     1 ? 
HETATM 9095 O O     . HOH J 5 .   ? -28.830 48.378  33.413 1.00 40.69  ? 998  HOH B O     1 ? 
HETATM 9096 O O     . HOH J 5 .   ? -55.834 41.994  35.588 1.00 48.80  ? 999  HOH B O     1 ? 
HETATM 9097 O O     . HOH J 5 .   ? -26.804 14.450  37.389 1.00 29.57  ? 1000 HOH B O     1 ? 
HETATM 9098 O O     . HOH J 5 .   ? -50.134 50.381  0.590  1.00 38.63  ? 1001 HOH B O     1 ? 
HETATM 9099 O O     . HOH J 5 .   ? -54.974 13.742  47.575 1.00 40.89  ? 1002 HOH B O     1 ? 
HETATM 9100 O O     . HOH J 5 .   ? -48.073 41.681  14.722 1.00 44.93  ? 1003 HOH B O     1 ? 
HETATM 9101 O O     . HOH J 5 .   ? -60.603 11.091  19.082 1.00 39.72  ? 1004 HOH B O     1 ? 
HETATM 9102 O O     . HOH J 5 .   ? -22.933 18.717  12.988 1.00 47.32  ? 1005 HOH B O     1 ? 
HETATM 9103 O O     . HOH J 5 .   ? -66.135 3.641   32.876 1.00 35.44  ? 1006 HOH B O     1 ? 
HETATM 9104 O O     . HOH J 5 .   ? -50.605 -2.929  18.069 1.00 52.83  ? 1007 HOH B O     1 ? 
HETATM 9105 O O     . HOH J 5 .   ? -36.094 30.190  40.211 1.00 47.46  ? 1008 HOH B O     1 ? 
HETATM 9106 O O     . HOH J 5 .   ? -31.393 28.043  36.684 1.00 42.97  ? 1009 HOH B O     1 ? 
HETATM 9107 O O     . HOH J 5 .   ? -62.318 28.207  11.102 1.00 50.43  ? 1010 HOH B O     1 ? 
HETATM 9108 O O     . HOH J 5 .   ? -45.789 56.828  30.127 1.00 41.62  ? 1011 HOH B O     1 ? 
HETATM 9109 O O     . HOH J 5 .   ? -62.712 27.262  15.592 1.00 43.24  ? 1012 HOH B O     1 ? 
HETATM 9110 O O     . HOH J 5 .   ? -27.940 53.960  23.250 1.00 36.70  ? 1013 HOH B O     1 ? 
HETATM 9111 O O     . HOH J 5 .   ? -46.451 58.213  27.915 1.00 41.59  ? 1014 HOH B O     1 ? 
HETATM 9112 O O     . HOH J 5 .   ? -29.951 34.216  34.883 1.00 51.26  ? 1015 HOH B O     1 ? 
HETATM 9113 O O     . HOH J 5 .   ? -57.948 29.729  32.389 1.00 29.96  ? 1016 HOH B O     1 ? 
HETATM 9114 O O     . HOH J 5 .   ? -32.691 32.033  9.392  1.00 32.31  ? 1017 HOH B O     1 ? 
HETATM 9115 O O     . HOH J 5 .   ? -46.389 -4.956  43.355 1.00 41.96  ? 1018 HOH B O     1 ? 
HETATM 9116 O O     . HOH J 5 .   ? -63.261 3.531   29.180 1.00 20.68  ? 1019 HOH B O     1 ? 
HETATM 9117 O O     . HOH J 5 .   ? -56.800 -0.968  33.923 1.00 42.62  ? 1020 HOH B O     1 ? 
HETATM 9118 O O     . HOH J 5 .   ? -34.346 26.621  40.431 1.00 42.30  ? 1021 HOH B O     1 ? 
HETATM 9119 O O     . HOH J 5 .   ? -58.689 14.373  44.535 1.00 45.01  ? 1022 HOH B O     1 ? 
HETATM 9120 O O     . HOH J 5 .   ? -39.096 -3.659  28.884 1.00 47.13  ? 1023 HOH B O     1 ? 
HETATM 9121 O O     . HOH J 5 .   ? -54.526 33.226  37.522 1.00 28.97  ? 1024 HOH B O     1 ? 
HETATM 9122 O O     . HOH J 5 .   ? -56.675 33.337  34.538 1.00 33.48  ? 1025 HOH B O     1 ? 
HETATM 9123 O O     . HOH J 5 .   ? -27.809 39.492  27.954 1.00 26.86  ? 1026 HOH B O     1 ? 
HETATM 9124 O O     . HOH J 5 .   ? -41.394 27.970  47.471 1.00 42.87  ? 1027 HOH B O     1 ? 
HETATM 9125 O O     . HOH J 5 .   ? -50.597 49.387  8.730  1.00 31.85  ? 1028 HOH B O     1 ? 
HETATM 9126 O O     . HOH J 5 .   ? -52.918 45.309  27.317 1.00 46.67  ? 1029 HOH B O     1 ? 
HETATM 9127 O O     . HOH J 5 .   ? -61.134 23.400  16.066 1.00 42.94  ? 1030 HOH B O     1 ? 
HETATM 9128 O O     . HOH J 5 .   ? -58.073 35.659  23.118 1.00 50.53  ? 1031 HOH B O     1 ? 
HETATM 9129 O O     . HOH J 5 .   ? -51.641 42.269  0.207  1.00 36.22  ? 1032 HOH B O     1 ? 
HETATM 9130 O O     . HOH J 5 .   ? -46.401 34.097  -1.258 1.00 48.44  ? 1033 HOH B O     1 ? 
HETATM 9131 O O     . HOH J 5 .   ? -54.707 5.352   40.422 1.00 39.21  ? 1034 HOH B O     1 ? 
HETATM 9132 O O     . HOH J 5 .   ? -45.421 27.028  46.610 1.00 41.69  ? 1035 HOH B O     1 ? 
HETATM 9133 O O     . HOH J 5 .   ? -31.708 32.482  38.369 1.00 47.79  ? 1036 HOH B O     1 ? 
HETATM 9134 O O     . HOH J 5 .   ? -56.877 29.808  37.022 1.00 31.63  ? 1037 HOH B O     1 ? 
HETATM 9135 O O     . HOH J 5 .   ? -37.198 26.744  46.068 1.00 46.78  ? 1038 HOH B O     1 ? 
HETATM 9136 O O     . HOH J 5 .   ? -60.602 0.731   31.895 1.00 45.70  ? 1039 HOH B O     1 ? 
HETATM 9137 O O     . HOH J 5 .   ? -58.976 34.622  28.176 1.00 41.95  ? 1040 HOH B O     1 ? 
HETATM 9138 O O     . HOH J 5 .   ? -38.132 41.265  30.819 1.00 27.08  ? 1041 HOH B O     1 ? 
HETATM 9139 O O     . HOH J 5 .   ? -35.486 1.837   21.585 1.00 50.21  ? 1042 HOH B O     1 ? 
HETATM 9140 O O     . HOH J 5 .   ? -33.320 62.401  27.035 1.00 53.00  ? 1043 HOH B O     1 ? 
HETATM 9141 O O     . HOH J 5 .   ? -52.604 38.920  24.367 1.00 44.09  ? 1044 HOH B O     1 ? 
HETATM 9142 O O     . HOH J 5 .   ? -54.171 45.153  10.343 1.00 53.60  ? 1045 HOH B O     1 ? 
HETATM 9143 O O     . HOH J 5 .   ? -44.320 63.321  22.186 1.00 49.89  ? 1046 HOH B O     1 ? 
HETATM 9144 O O     . HOH J 5 .   ? -29.184 54.582  27.315 1.00 37.19  ? 1047 HOH B O     1 ? 
HETATM 9145 O O     . HOH J 5 .   ? -51.455 -3.018  29.363 1.00 53.52  ? 1048 HOH B O     1 ? 
HETATM 9146 O O     . HOH J 5 .   ? -51.771 41.256  10.729 1.00 39.14  ? 1049 HOH B O     1 ? 
HETATM 9147 O O     . HOH J 5 .   ? -33.550 52.441  35.153 1.00 50.53  ? 1050 HOH B O     1 ? 
HETATM 9148 O O     . HOH J 5 .   ? -51.935 42.075  23.573 1.00 49.64  ? 1051 HOH B O     1 ? 
HETATM 9149 O O     . HOH J 5 .   ? -63.925 30.945  16.042 1.00 49.67  ? 1052 HOH B O     1 ? 
HETATM 9150 O O     . HOH J 5 .   ? -51.216 30.295  44.863 1.00 36.65  ? 1053 HOH B O     1 ? 
HETATM 9151 O O     . HOH J 5 .   ? -57.143 39.048  16.314 1.00 46.31  ? 1054 HOH B O     1 ? 
HETATM 9152 O O     . HOH J 5 .   ? -50.376 31.864  42.537 1.00 28.75  ? 1055 HOH B O     1 ? 
HETATM 9153 O O     . HOH J 5 .   ? -28.989 13.428  3.837  1.00 58.35  ? 1056 HOH B O     1 ? 
HETATM 9154 O O     . HOH J 5 .   ? -50.936 36.948  19.491 1.00 42.66  ? 1057 HOH B O     1 ? 
HETATM 9155 O O     . HOH J 5 .   ? -52.699 33.229  42.394 1.00 37.43  ? 1058 HOH B O     1 ? 
# 
