data_8RJS
# 
_entry.id   8RJS 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.404 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8RJS         pdb_00008rjs 10.2210/pdb8rjs/pdb 
WWPDB D_1292133794 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-05-14 ? 
2 'Structure model' 1 1 2025-06-11 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation.pdbx_database_id_DOI'    
5 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
6 2 'Structure model' '_citation.title'                   
# 
loop_
_database_PDB_caveat.id 
_database_PDB_caveat.text 
1 'EL5 A 601 HAS WRONG CHIRALITY AT ATOM C2A' 
2 'EL5 B 601 HAS WRONG CHIRALITY AT ATOM C2A' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8RJS 
_pdbx_database_status.recvd_initial_deposition_date   2023-12-21 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.details 
_pdbx_database_related.db_id 
_pdbx_database_related.content_type 
PDB 'Agp2 - Pfr'                    6G1Y unspecified 
PDB 'PAiRFP2 - Pfr'                 6G1Z unspecified 
PDB 'PAiRFP2 - Meta-F'              6G20 unspecified 
PDB 'PAiRFP2 SFX - Pfr (I0a)'       8RJM unspecified 
PDB 'PAiRFP2 SFX - Pfr (I0b)'       8RJN unspecified 
PDB 'PAiRFP2 SFX - intermediate I1' 8RJO unspecified 
PDB 'PAiRFP2 SFX - intermediate I2' 8RJP unspecified 
PDB 'PAiRFP2 SFX - intermediate I3' 8RJQ unspecified 
PDB 'PAiRFP2 SFX - intermediate I4' 8RJR unspecified 
PDB 'PAiRFP2 SFX - intermediate I6' 8RJT unspecified 
PDB 'PAiRFP2 SFX - intermediate I7' 8RJU unspecified 
# 
_pdbx_contact_author.id                 4 
_pdbx_contact_author.email              patrick.scheerer@charite.de 
_pdbx_contact_author.name_first         Patrick 
_pdbx_contact_author.name_last          Scheerer 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-5028-2075 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Sauthof, L.'    1 ? 
'Schmidt, A.'    2 ? 
'Szczepek, M.'   3 ? 
'Brewster, A.S.' 4 ? 
'Kern, J.F.'     5 ? 
'Scheerer, P.'   6 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Sci Adv' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2375-2548 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            11 
_citation.language                  ? 
_citation.page_first                eadp2665 
_citation.page_last                 eadp2665 
_citation.title                     
'Serial-femtosecond crystallography reveals how a phytochrome variant couples chromophore and protein structural changes.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1126/sciadv.adp2665 
_citation.pdbx_database_id_PubMed   40435264 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Sauthof, L.'       1  0000-0002-6727-8395 
primary 'Szczepek, M.'      2  0000-0001-5079-6893 
primary 'Schmidt, A.'       3  0000-0003-1985-1908 
primary 'Bhowmick, A.'      4  0000-0002-6154-6635 
primary 'Dasgupta, M.'      5  0000-0003-2509-3699 
primary 'Mackintosh, M.J.'  6  0000-0002-4913-0848 
primary 'Gul, S.'           7  0000-0001-8920-8737 
primary 'Fuller, F.D.'      8  ?                   
primary 'Chatterjee, R.'    9  ?                   
primary 'Young, I.D.'       10 0000-0003-4713-9504 
primary 'Michael, N.'       11 0000-0002-6722-416X 
primary 'Heyder, N.A.'      12 0000-0002-8755-5433 
primary 'Bauer, B.'         13 ?                   
primary 'Koch, A.'          14 0009-0004-9304-4092 
primary 'Bogacz, I.'        15 0000-0003-1493-3867 
primary 'Kim, I.S.'         16 0000-0002-0258-6012 
primary 'Simon, P.S.'       17 0000-0002-2859-4475 
primary 'Butryn, A.'        18 0000-0002-5227-4770 
primary 'Aller, P.'         19 0000-0002-1793-7030 
primary 'Chukhutsina, V.U.' 20 0000-0003-0304-5573 
primary 'Baxter, J.M.'      21 0000-0002-4641-6760 
primary 'Hutchison, C.D.M.' 22 0000-0002-2225-2562 
primary 'Liebschner, D.'    23 0000-0003-3921-3209 
primary 'Poon, B.'          24 0000-0001-9633-6067 
primary 'Sauter, N.K.'      25 0000-0003-2786-6552 
primary 'Miller, M.D.'      26 0000-0003-1626-4943 
primary 'Alonso-Mori, R.'   27 0000-0002-5357-0934 
primary 'Hunter, M.S.'      28 ?                   
primary 'Batyuk, A.'        29 0000-0002-9393-2880 
primary 'Owada, S.'         30 0000-0002-1451-7612 
primary 'Tono, K.'          31 0000-0003-1218-3759 
primary 'Tanaka, R.'        32 0000-0003-1062-4792 
primary 'van Thor, J.J.'    33 0000-0001-6356-3116 
primary 'Krauss, N.'        34 0000-0002-7128-4632 
primary 'Lamparter, T.'     35 0000-0003-4327-9737 
primary 'Brewster, A.S.'    36 0000-0002-0908-7822 
primary 'Schapiro, I.'      37 0000-0001-8536-6869 
primary 'Orville, A.M.'     38 0000-0002-7803-1777 
primary 'Yachandra, V.K.'   39 0000-0002-3983-7858 
primary 'Yano, J.'          40 0000-0001-6308-9071 
primary 'Hildebrandt, P.'   41 0000-0003-1030-5900 
primary 'Kern, J.F.'        42 0000-0002-7272-1603 
primary 'Scheerer, P.'      43 0000-0001-5028-2075 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'histidine kinase' 57507.484 2  2.7.13.3 
;K69R, R83K, G120D, A123T, M163L, Q168E, R220P, S243N, V244F, G269D, A276V, Y270C, E294A, H303F, H333R, I336L, D349R, M351I, A386V, G409D, L419I, T469S, A487T, E494G
;
? ? 
2 non-polymer syn 
;3-[(2Z)-2-({3-(2-carboxyethyl)-5-[(E)-(4-ethenyl-3-methyl-5-oxo-1,5-dihydro-2H-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl}methylidene)-5-{(Z)-[(3E,4S)-3-ethylidene-4-methyl-5-oxopyrrolidin-2-ylidene]methyl}-4-methyl-2H-pyrrol-3-yl]propanoic acid
;
584.662   2  ?        ? ? ? 
3 non-polymer syn 'SULFATE ION' 96.063    5  ?        ? ? ? 
4 non-polymer syn 'CHLORIDE ION' 35.453    1  ?        ? ? ? 
5 water       nat water 18.015    88 ?        ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MASTDYHVDLTNCDREPIHIPGYIQPHGCLIACDNAMRMVLRHSENCGELLGLEGDLNGRTAEDVLGKRLVHDLRNALTV
TGKTTRPAMLPAMETSDGRSFDISLHRYKSTTIIEFEPSDSDTQPLGTARKMVDRIREADSVESLISRTTRLVKATLGYD
RVLIYRFEEDGAGKVVSEAKQPELESFLGQYFPASDIPQQARALYLKNTLRIISDASGTPIPVLPAVDVSGEPLDLSYAH
LRNFSPIHCEYLRNMGVAASMSISVIVDDALWGLIVCHHCSPRVLSMPVRIAAAMFGEFFSMFLQVLKQKRRLDTINHAH
AALDRFLRLAAHRANLEELLVDSFQDFARLIPCDGVGLWVGNNWHGHGATPPHDAIPRLARFVASVSEGRVWATHALSQA
IPEAEIYADTAAGMLAIPISQVKSDYLLFFRKEIVQNLNWAGNPEKSYETGPMGDRLTPRKSFAIWKESVRLQAQPWSEA
DREIAETARIALVGVAFHHSELMAGLEYKHHHHHH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MASTDYHVDLTNCDREPIHIPGYIQPHGCLIACDNAMRMVLRHSENCGELLGLEGDLNGRTAEDVLGKRLVHDLRNALTV
TGKTTRPAMLPAMETSDGRSFDISLHRYKSTTIIEFEPSDSDTQPLGTARKMVDRIREADSVESLISRTTRLVKATLGYD
RVLIYRFEEDGAGKVVSEAKQPELESFLGQYFPASDIPQQARALYLKNTLRIISDASGTPIPVLPAVDVSGEPLDLSYAH
LRNFSPIHCEYLRNMGVAASMSISVIVDDALWGLIVCHHCSPRVLSMPVRIAAAMFGEFFSMFLQVLKQKRRLDTINHAH
AALDRFLRLAAHRANLEELLVDSFQDFARLIPCDGVGLWVGNNWHGHGATPPHDAIPRLARFVASVSEGRVWATHALSQA
IPEAEIYADTAAGMLAIPISQVKSDYLLFFRKEIVQNLNWAGNPEKSYETGPMGDRLTPRKSFAIWKESVRLQAQPWSEA
DREIAETARIALVGVAFHHSELMAGLEYKHHHHHH
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 
;3-[(2Z)-2-({3-(2-carboxyethyl)-5-[(E)-(4-ethenyl-3-methyl-5-oxo-1,5-dihydro-2H-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl}methylidene)-5-{(Z)-[(3E,4S)-3-ethylidene-4-methyl-5-oxopyrrolidin-2-ylidene]methyl}-4-methyl-2H-pyrrol-3-yl]propanoic acid
;
EL5 
3 'SULFATE ION' SO4 
4 'CHLORIDE ION' CL  
5 water HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   SER n 
1 4   THR n 
1 5   ASP n 
1 6   TYR n 
1 7   HIS n 
1 8   VAL n 
1 9   ASP n 
1 10  LEU n 
1 11  THR n 
1 12  ASN n 
1 13  CYS n 
1 14  ASP n 
1 15  ARG n 
1 16  GLU n 
1 17  PRO n 
1 18  ILE n 
1 19  HIS n 
1 20  ILE n 
1 21  PRO n 
1 22  GLY n 
1 23  TYR n 
1 24  ILE n 
1 25  GLN n 
1 26  PRO n 
1 27  HIS n 
1 28  GLY n 
1 29  CYS n 
1 30  LEU n 
1 31  ILE n 
1 32  ALA n 
1 33  CYS n 
1 34  ASP n 
1 35  ASN n 
1 36  ALA n 
1 37  MET n 
1 38  ARG n 
1 39  MET n 
1 40  VAL n 
1 41  LEU n 
1 42  ARG n 
1 43  HIS n 
1 44  SER n 
1 45  GLU n 
1 46  ASN n 
1 47  CYS n 
1 48  GLY n 
1 49  GLU n 
1 50  LEU n 
1 51  LEU n 
1 52  GLY n 
1 53  LEU n 
1 54  GLU n 
1 55  GLY n 
1 56  ASP n 
1 57  LEU n 
1 58  ASN n 
1 59  GLY n 
1 60  ARG n 
1 61  THR n 
1 62  ALA n 
1 63  GLU n 
1 64  ASP n 
1 65  VAL n 
1 66  LEU n 
1 67  GLY n 
1 68  LYS n 
1 69  ARG n 
1 70  LEU n 
1 71  VAL n 
1 72  HIS n 
1 73  ASP n 
1 74  LEU n 
1 75  ARG n 
1 76  ASN n 
1 77  ALA n 
1 78  LEU n 
1 79  THR n 
1 80  VAL n 
1 81  THR n 
1 82  GLY n 
1 83  LYS n 
1 84  THR n 
1 85  THR n 
1 86  ARG n 
1 87  PRO n 
1 88  ALA n 
1 89  MET n 
1 90  LEU n 
1 91  PRO n 
1 92  ALA n 
1 93  MET n 
1 94  GLU n 
1 95  THR n 
1 96  SER n 
1 97  ASP n 
1 98  GLY n 
1 99  ARG n 
1 100 SER n 
1 101 PHE n 
1 102 ASP n 
1 103 ILE n 
1 104 SER n 
1 105 LEU n 
1 106 HIS n 
1 107 ARG n 
1 108 TYR n 
1 109 LYS n 
1 110 SER n 
1 111 THR n 
1 112 THR n 
1 113 ILE n 
1 114 ILE n 
1 115 GLU n 
1 116 PHE n 
1 117 GLU n 
1 118 PRO n 
1 119 SER n 
1 120 ASP n 
1 121 SER n 
1 122 ASP n 
1 123 THR n 
1 124 GLN n 
1 125 PRO n 
1 126 LEU n 
1 127 GLY n 
1 128 THR n 
1 129 ALA n 
1 130 ARG n 
1 131 LYS n 
1 132 MET n 
1 133 VAL n 
1 134 ASP n 
1 135 ARG n 
1 136 ILE n 
1 137 ARG n 
1 138 GLU n 
1 139 ALA n 
1 140 ASP n 
1 141 SER n 
1 142 VAL n 
1 143 GLU n 
1 144 SER n 
1 145 LEU n 
1 146 ILE n 
1 147 SER n 
1 148 ARG n 
1 149 THR n 
1 150 THR n 
1 151 ARG n 
1 152 LEU n 
1 153 VAL n 
1 154 LYS n 
1 155 ALA n 
1 156 THR n 
1 157 LEU n 
1 158 GLY n 
1 159 TYR n 
1 160 ASP n 
1 161 ARG n 
1 162 VAL n 
1 163 LEU n 
1 164 ILE n 
1 165 TYR n 
1 166 ARG n 
1 167 PHE n 
1 168 GLU n 
1 169 GLU n 
1 170 ASP n 
1 171 GLY n 
1 172 ALA n 
1 173 GLY n 
1 174 LYS n 
1 175 VAL n 
1 176 VAL n 
1 177 SER n 
1 178 GLU n 
1 179 ALA n 
1 180 LYS n 
1 181 GLN n 
1 182 PRO n 
1 183 GLU n 
1 184 LEU n 
1 185 GLU n 
1 186 SER n 
1 187 PHE n 
1 188 LEU n 
1 189 GLY n 
1 190 GLN n 
1 191 TYR n 
1 192 PHE n 
1 193 PRO n 
1 194 ALA n 
1 195 SER n 
1 196 ASP n 
1 197 ILE n 
1 198 PRO n 
1 199 GLN n 
1 200 GLN n 
1 201 ALA n 
1 202 ARG n 
1 203 ALA n 
1 204 LEU n 
1 205 TYR n 
1 206 LEU n 
1 207 LYS n 
1 208 ASN n 
1 209 THR n 
1 210 LEU n 
1 211 ARG n 
1 212 ILE n 
1 213 ILE n 
1 214 SER n 
1 215 ASP n 
1 216 ALA n 
1 217 SER n 
1 218 GLY n 
1 219 THR n 
1 220 PRO n 
1 221 ILE n 
1 222 PRO n 
1 223 VAL n 
1 224 LEU n 
1 225 PRO n 
1 226 ALA n 
1 227 VAL n 
1 228 ASP n 
1 229 VAL n 
1 230 SER n 
1 231 GLY n 
1 232 GLU n 
1 233 PRO n 
1 234 LEU n 
1 235 ASP n 
1 236 LEU n 
1 237 SER n 
1 238 TYR n 
1 239 ALA n 
1 240 HIS n 
1 241 LEU n 
1 242 ARG n 
1 243 ASN n 
1 244 PHE n 
1 245 SER n 
1 246 PRO n 
1 247 ILE n 
1 248 HIS n 
1 249 CYS n 
1 250 GLU n 
1 251 TYR n 
1 252 LEU n 
1 253 ARG n 
1 254 ASN n 
1 255 MET n 
1 256 GLY n 
1 257 VAL n 
1 258 ALA n 
1 259 ALA n 
1 260 SER n 
1 261 MET n 
1 262 SER n 
1 263 ILE n 
1 264 SER n 
1 265 VAL n 
1 266 ILE n 
1 267 VAL n 
1 268 ASP n 
1 269 ASP n 
1 270 ALA n 
1 271 LEU n 
1 272 TRP n 
1 273 GLY n 
1 274 LEU n 
1 275 ILE n 
1 276 VAL n 
1 277 CYS n 
1 278 HIS n 
1 279 HIS n 
1 280 CYS n 
1 281 SER n 
1 282 PRO n 
1 283 ARG n 
1 284 VAL n 
1 285 LEU n 
1 286 SER n 
1 287 MET n 
1 288 PRO n 
1 289 VAL n 
1 290 ARG n 
1 291 ILE n 
1 292 ALA n 
1 293 ALA n 
1 294 ALA n 
1 295 MET n 
1 296 PHE n 
1 297 GLY n 
1 298 GLU n 
1 299 PHE n 
1 300 PHE n 
1 301 SER n 
1 302 MET n 
1 303 PHE n 
1 304 LEU n 
1 305 GLN n 
1 306 VAL n 
1 307 LEU n 
1 308 LYS n 
1 309 GLN n 
1 310 LYS n 
1 311 ARG n 
1 312 ARG n 
1 313 LEU n 
1 314 ASP n 
1 315 THR n 
1 316 ILE n 
1 317 ASN n 
1 318 HIS n 
1 319 ALA n 
1 320 HIS n 
1 321 ALA n 
1 322 ALA n 
1 323 LEU n 
1 324 ASP n 
1 325 ARG n 
1 326 PHE n 
1 327 LEU n 
1 328 ARG n 
1 329 LEU n 
1 330 ALA n 
1 331 ALA n 
1 332 HIS n 
1 333 ARG n 
1 334 ALA n 
1 335 ASN n 
1 336 LEU n 
1 337 GLU n 
1 338 GLU n 
1 339 LEU n 
1 340 LEU n 
1 341 VAL n 
1 342 ASP n 
1 343 SER n 
1 344 PHE n 
1 345 GLN n 
1 346 ASP n 
1 347 PHE n 
1 348 ALA n 
1 349 ARG n 
1 350 LEU n 
1 351 ILE n 
1 352 PRO n 
1 353 CYS n 
1 354 ASP n 
1 355 GLY n 
1 356 VAL n 
1 357 GLY n 
1 358 LEU n 
1 359 TRP n 
1 360 VAL n 
1 361 GLY n 
1 362 ASN n 
1 363 ASN n 
1 364 TRP n 
1 365 HIS n 
1 366 GLY n 
1 367 HIS n 
1 368 GLY n 
1 369 ALA n 
1 370 THR n 
1 371 PRO n 
1 372 PRO n 
1 373 HIS n 
1 374 ASP n 
1 375 ALA n 
1 376 ILE n 
1 377 PRO n 
1 378 ARG n 
1 379 LEU n 
1 380 ALA n 
1 381 ARG n 
1 382 PHE n 
1 383 VAL n 
1 384 ALA n 
1 385 SER n 
1 386 VAL n 
1 387 SER n 
1 388 GLU n 
1 389 GLY n 
1 390 ARG n 
1 391 VAL n 
1 392 TRP n 
1 393 ALA n 
1 394 THR n 
1 395 HIS n 
1 396 ALA n 
1 397 LEU n 
1 398 SER n 
1 399 GLN n 
1 400 ALA n 
1 401 ILE n 
1 402 PRO n 
1 403 GLU n 
1 404 ALA n 
1 405 GLU n 
1 406 ILE n 
1 407 TYR n 
1 408 ALA n 
1 409 ASP n 
1 410 THR n 
1 411 ALA n 
1 412 ALA n 
1 413 GLY n 
1 414 MET n 
1 415 LEU n 
1 416 ALA n 
1 417 ILE n 
1 418 PRO n 
1 419 ILE n 
1 420 SER n 
1 421 GLN n 
1 422 VAL n 
1 423 LYS n 
1 424 SER n 
1 425 ASP n 
1 426 TYR n 
1 427 LEU n 
1 428 LEU n 
1 429 PHE n 
1 430 PHE n 
1 431 ARG n 
1 432 LYS n 
1 433 GLU n 
1 434 ILE n 
1 435 VAL n 
1 436 GLN n 
1 437 ASN n 
1 438 LEU n 
1 439 ASN n 
1 440 TRP n 
1 441 ALA n 
1 442 GLY n 
1 443 ASN n 
1 444 PRO n 
1 445 GLU n 
1 446 LYS n 
1 447 SER n 
1 448 TYR n 
1 449 GLU n 
1 450 THR n 
1 451 GLY n 
1 452 PRO n 
1 453 MET n 
1 454 GLY n 
1 455 ASP n 
1 456 ARG n 
1 457 LEU n 
1 458 THR n 
1 459 PRO n 
1 460 ARG n 
1 461 LYS n 
1 462 SER n 
1 463 PHE n 
1 464 ALA n 
1 465 ILE n 
1 466 TRP n 
1 467 LYS n 
1 468 GLU n 
1 469 SER n 
1 470 VAL n 
1 471 ARG n 
1 472 LEU n 
1 473 GLN n 
1 474 ALA n 
1 475 GLN n 
1 476 PRO n 
1 477 TRP n 
1 478 SER n 
1 479 GLU n 
1 480 ALA n 
1 481 ASP n 
1 482 ARG n 
1 483 GLU n 
1 484 ILE n 
1 485 ALA n 
1 486 GLU n 
1 487 THR n 
1 488 ALA n 
1 489 ARG n 
1 490 ILE n 
1 491 ALA n 
1 492 LEU n 
1 493 VAL n 
1 494 GLY n 
1 495 VAL n 
1 496 ALA n 
1 497 PHE n 
1 498 HIS n 
1 499 HIS n 
1 500 SER n 
1 501 GLU n 
1 502 LEU n 
1 503 MET n 
1 504 ALA n 
1 505 GLY n 
1 506 LEU n 
1 507 GLU n 
1 508 TYR n 
1 509 LYS n 
1 510 HIS n 
1 511 HIS n 
1 512 HIS n 
1 513 HIS n 
1 514 HIS n 
1 515 HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   515 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 Atu2165 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Agrobacterium fabrum str. C58' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     176299 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          Plasmid 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE ?                                     'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE ?                                     'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE ?                                     'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ?                                     'C4 H7 N O4'     133.103 
CL  non-polymer         . 'CHLORIDE ION' ?                                     'Cl -1'          35.453  
CYS 'L-peptide linking' y CYSTEINE ?                                     'C3 H7 N O2 S'   121.158 
EL5 non-polymer         . 
;3-[(2Z)-2-({3-(2-carboxyethyl)-5-[(E)-(4-ethenyl-3-methyl-5-oxo-1,5-dihydro-2H-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl}methylidene)-5-{(Z)-[(3E,4S)-3-ethylidene-4-methyl-5-oxopyrrolidin-2-ylidene]methyl}-4-methyl-2H-pyrrol-3-yl]propanoic acid
;
'biliverdin, bound form at Pfr state' 'C33 H36 N4 O6'  584.662 
GLN 'L-peptide linking' y GLUTAMINE ?                                     'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ?                                     'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE ?                                     'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE ?                                     'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER ?                                     'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE ?                                     'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE ?                                     'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE ?                                     'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE ?                                     'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE ?                                     'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE ?                                     'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE ?                                     'C3 H7 N O3'     105.093 
SO4 non-polymer         . 'SULFATE ION' ?                                     'O4 S -2'        96.063  
THR 'L-peptide linking' y THREONINE ?                                     'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN ?                                     'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE ?                                     'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE ?                                     'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   ALA 2   2   ?   ?   ?   A . n 
A 1 3   SER 3   3   ?   ?   ?   A . n 
A 1 4   THR 4   4   ?   ?   ?   A . n 
A 1 5   ASP 5   5   ?   ?   ?   A . n 
A 1 6   TYR 6   6   ?   ?   ?   A . n 
A 1 7   HIS 7   7   ?   ?   ?   A . n 
A 1 8   VAL 8   8   8   VAL VAL A . n 
A 1 9   ASP 9   9   9   ASP ASP A . n 
A 1 10  LEU 10  10  10  LEU LEU A . n 
A 1 11  THR 11  11  11  THR THR A . n 
A 1 12  ASN 12  12  12  ASN ASN A . n 
A 1 13  CYS 13  13  13  CYS CYS A . n 
A 1 14  ASP 14  14  14  ASP ASP A . n 
A 1 15  ARG 15  15  15  ARG ARG A . n 
A 1 16  GLU 16  16  16  GLU GLU A . n 
A 1 17  PRO 17  17  17  PRO PRO A . n 
A 1 18  ILE 18  18  18  ILE ILE A . n 
A 1 19  HIS 19  19  19  HIS HIS A . n 
A 1 20  ILE 20  20  20  ILE ILE A . n 
A 1 21  PRO 21  21  21  PRO PRO A . n 
A 1 22  GLY 22  22  22  GLY GLY A . n 
A 1 23  TYR 23  23  23  TYR TYR A . n 
A 1 24  ILE 24  24  24  ILE ILE A . n 
A 1 25  GLN 25  25  25  GLN GLN A . n 
A 1 26  PRO 26  26  26  PRO PRO A . n 
A 1 27  HIS 27  27  27  HIS HIS A . n 
A 1 28  GLY 28  28  28  GLY GLY A . n 
A 1 29  CYS 29  29  29  CYS CYS A . n 
A 1 30  LEU 30  30  30  LEU LEU A . n 
A 1 31  ILE 31  31  31  ILE ILE A . n 
A 1 32  ALA 32  32  32  ALA ALA A . n 
A 1 33  CYS 33  33  33  CYS CYS A . n 
A 1 34  ASP 34  34  34  ASP ASP A . n 
A 1 35  ASN 35  35  35  ASN ASN A . n 
A 1 36  ALA 36  36  36  ALA ALA A . n 
A 1 37  MET 37  37  37  MET MET A . n 
A 1 38  ARG 38  38  38  ARG ARG A . n 
A 1 39  MET 39  39  39  MET MET A . n 
A 1 40  VAL 40  40  40  VAL VAL A . n 
A 1 41  LEU 41  41  41  LEU LEU A . n 
A 1 42  ARG 42  42  42  ARG ARG A . n 
A 1 43  HIS 43  43  43  HIS HIS A . n 
A 1 44  SER 44  44  44  SER SER A . n 
A 1 45  GLU 45  45  45  GLU GLU A . n 
A 1 46  ASN 46  46  46  ASN ASN A . n 
A 1 47  CYS 47  47  47  CYS CYS A . n 
A 1 48  GLY 48  48  48  GLY GLY A . n 
A 1 49  GLU 49  49  49  GLU GLU A . n 
A 1 50  LEU 50  50  50  LEU LEU A . n 
A 1 51  LEU 51  51  51  LEU LEU A . n 
A 1 52  GLY 52  52  52  GLY GLY A . n 
A 1 53  LEU 53  53  53  LEU LEU A . n 
A 1 54  GLU 54  54  54  GLU GLU A . n 
A 1 55  GLY 55  55  55  GLY GLY A . n 
A 1 56  ASP 56  56  56  ASP ASP A . n 
A 1 57  LEU 57  57  57  LEU LEU A . n 
A 1 58  ASN 58  58  58  ASN ASN A . n 
A 1 59  GLY 59  59  59  GLY GLY A . n 
A 1 60  ARG 60  60  60  ARG ARG A . n 
A 1 61  THR 61  61  61  THR THR A . n 
A 1 62  ALA 62  62  62  ALA ALA A . n 
A 1 63  GLU 63  63  63  GLU GLU A . n 
A 1 64  ASP 64  64  64  ASP ASP A . n 
A 1 65  VAL 65  65  65  VAL VAL A . n 
A 1 66  LEU 66  66  66  LEU LEU A . n 
A 1 67  GLY 67  67  67  GLY GLY A . n 
A 1 68  LYS 68  68  68  LYS LYS A . n 
A 1 69  ARG 69  69  69  ARG ARG A . n 
A 1 70  LEU 70  70  70  LEU LEU A . n 
A 1 71  VAL 71  71  71  VAL VAL A . n 
A 1 72  HIS 72  72  72  HIS HIS A . n 
A 1 73  ASP 73  73  73  ASP ASP A . n 
A 1 74  LEU 74  74  74  LEU LEU A . n 
A 1 75  ARG 75  75  75  ARG ARG A . n 
A 1 76  ASN 76  76  76  ASN ASN A . n 
A 1 77  ALA 77  77  77  ALA ALA A . n 
A 1 78  LEU 78  78  78  LEU LEU A . n 
A 1 79  THR 79  79  79  THR THR A . n 
A 1 80  VAL 80  80  ?   ?   ?   A . n 
A 1 81  THR 81  81  ?   ?   ?   A . n 
A 1 82  GLY 82  82  ?   ?   ?   A . n 
A 1 83  LYS 83  83  ?   ?   ?   A . n 
A 1 84  THR 84  84  84  THR THR A . n 
A 1 85  THR 85  85  85  THR THR A . n 
A 1 86  ARG 86  86  86  ARG ARG A . n 
A 1 87  PRO 87  87  87  PRO PRO A . n 
A 1 88  ALA 88  88  88  ALA ALA A . n 
A 1 89  MET 89  89  89  MET MET A . n 
A 1 90  LEU 90  90  90  LEU LEU A . n 
A 1 91  PRO 91  91  91  PRO PRO A . n 
A 1 92  ALA 92  92  92  ALA ALA A . n 
A 1 93  MET 93  93  93  MET MET A . n 
A 1 94  GLU 94  94  94  GLU GLU A . n 
A 1 95  THR 95  95  95  THR THR A . n 
A 1 96  SER 96  96  96  SER SER A . n 
A 1 97  ASP 97  97  97  ASP ASP A . n 
A 1 98  GLY 98  98  98  GLY GLY A . n 
A 1 99  ARG 99  99  99  ARG ARG A . n 
A 1 100 SER 100 100 100 SER SER A . n 
A 1 101 PHE 101 101 101 PHE PHE A . n 
A 1 102 ASP 102 102 102 ASP ASP A . n 
A 1 103 ILE 103 103 103 ILE ILE A . n 
A 1 104 SER 104 104 104 SER SER A . n 
A 1 105 LEU 105 105 105 LEU LEU A . n 
A 1 106 HIS 106 106 106 HIS HIS A . n 
A 1 107 ARG 107 107 107 ARG ARG A . n 
A 1 108 TYR 108 108 108 TYR TYR A . n 
A 1 109 LYS 109 109 109 LYS LYS A . n 
A 1 110 SER 110 110 110 SER SER A . n 
A 1 111 THR 111 111 111 THR THR A . n 
A 1 112 THR 112 112 112 THR THR A . n 
A 1 113 ILE 113 113 113 ILE ILE A . n 
A 1 114 ILE 114 114 114 ILE ILE A . n 
A 1 115 GLU 115 115 115 GLU GLU A . n 
A 1 116 PHE 116 116 116 PHE PHE A . n 
A 1 117 GLU 117 117 117 GLU GLU A . n 
A 1 118 PRO 118 118 118 PRO PRO A . n 
A 1 119 SER 119 119 119 SER SER A . n 
A 1 120 ASP 120 120 ?   ?   ?   A . n 
A 1 121 SER 121 121 121 SER SER A . n 
A 1 122 ASP 122 122 122 ASP ASP A . n 
A 1 123 THR 123 123 123 THR THR A . n 
A 1 124 GLN 124 124 124 GLN GLN A . n 
A 1 125 PRO 125 125 125 PRO PRO A . n 
A 1 126 LEU 126 126 126 LEU LEU A . n 
A 1 127 GLY 127 127 127 GLY GLY A . n 
A 1 128 THR 128 128 128 THR THR A . n 
A 1 129 ALA 129 129 129 ALA ALA A . n 
A 1 130 ARG 130 130 130 ARG ARG A . n 
A 1 131 LYS 131 131 131 LYS LYS A . n 
A 1 132 MET 132 132 132 MET MET A . n 
A 1 133 VAL 133 133 133 VAL VAL A . n 
A 1 134 ASP 134 134 134 ASP ASP A . n 
A 1 135 ARG 135 135 135 ARG ARG A . n 
A 1 136 ILE 136 136 136 ILE ILE A . n 
A 1 137 ARG 137 137 137 ARG ARG A . n 
A 1 138 GLU 138 138 138 GLU GLU A . n 
A 1 139 ALA 139 139 139 ALA ALA A . n 
A 1 140 ASP 140 140 140 ASP ASP A . n 
A 1 141 SER 141 141 141 SER SER A . n 
A 1 142 VAL 142 142 142 VAL VAL A . n 
A 1 143 GLU 143 143 143 GLU GLU A . n 
A 1 144 SER 144 144 144 SER SER A . n 
A 1 145 LEU 145 145 145 LEU LEU A . n 
A 1 146 ILE 146 146 146 ILE ILE A . n 
A 1 147 SER 147 147 147 SER SER A . n 
A 1 148 ARG 148 148 148 ARG ARG A . n 
A 1 149 THR 149 149 149 THR THR A . n 
A 1 150 THR 150 150 150 THR THR A . n 
A 1 151 ARG 151 151 151 ARG ARG A . n 
A 1 152 LEU 152 152 152 LEU LEU A . n 
A 1 153 VAL 153 153 153 VAL VAL A . n 
A 1 154 LYS 154 154 154 LYS LYS A . n 
A 1 155 ALA 155 155 155 ALA ALA A . n 
A 1 156 THR 156 156 156 THR THR A . n 
A 1 157 LEU 157 157 157 LEU LEU A . n 
A 1 158 GLY 158 158 158 GLY GLY A . n 
A 1 159 TYR 159 159 159 TYR TYR A . n 
A 1 160 ASP 160 160 160 ASP ASP A . n 
A 1 161 ARG 161 161 161 ARG ARG A . n 
A 1 162 VAL 162 162 162 VAL VAL A . n 
A 1 163 LEU 163 163 163 LEU LEU A . n 
A 1 164 ILE 164 164 164 ILE ILE A . n 
A 1 165 TYR 165 165 165 TYR TYR A . n 
A 1 166 ARG 166 166 166 ARG ARG A . n 
A 1 167 PHE 167 167 167 PHE PHE A . n 
A 1 168 GLU 168 168 168 GLU GLU A . n 
A 1 169 GLU 169 169 169 GLU GLU A . n 
A 1 170 ASP 170 170 170 ASP ASP A . n 
A 1 171 GLY 171 171 171 GLY GLY A . n 
A 1 172 ALA 172 172 172 ALA ALA A . n 
A 1 173 GLY 173 173 173 GLY GLY A . n 
A 1 174 LYS 174 174 174 LYS LYS A . n 
A 1 175 VAL 175 175 175 VAL VAL A . n 
A 1 176 VAL 176 176 176 VAL VAL A . n 
A 1 177 SER 177 177 177 SER SER A . n 
A 1 178 GLU 178 178 178 GLU GLU A . n 
A 1 179 ALA 179 179 179 ALA ALA A . n 
A 1 180 LYS 180 180 180 LYS LYS A . n 
A 1 181 GLN 181 181 181 GLN GLN A . n 
A 1 182 PRO 182 182 182 PRO PRO A . n 
A 1 183 GLU 183 183 183 GLU GLU A . n 
A 1 184 LEU 184 184 184 LEU LEU A . n 
A 1 185 GLU 185 185 185 GLU GLU A . n 
A 1 186 SER 186 186 186 SER SER A . n 
A 1 187 PHE 187 187 187 PHE PHE A . n 
A 1 188 LEU 188 188 188 LEU LEU A . n 
A 1 189 GLY 189 189 189 GLY GLY A . n 
A 1 190 GLN 190 190 190 GLN GLN A . n 
A 1 191 TYR 191 191 191 TYR TYR A . n 
A 1 192 PHE 192 192 192 PHE PHE A . n 
A 1 193 PRO 193 193 193 PRO PRO A . n 
A 1 194 ALA 194 194 194 ALA ALA A . n 
A 1 195 SER 195 195 195 SER SER A . n 
A 1 196 ASP 196 196 196 ASP ASP A . n 
A 1 197 ILE 197 197 197 ILE ILE A . n 
A 1 198 PRO 198 198 198 PRO PRO A . n 
A 1 199 GLN 199 199 199 GLN GLN A . n 
A 1 200 GLN 200 200 200 GLN GLN A . n 
A 1 201 ALA 201 201 201 ALA ALA A . n 
A 1 202 ARG 202 202 202 ARG ARG A . n 
A 1 203 ALA 203 203 203 ALA ALA A . n 
A 1 204 LEU 204 204 204 LEU LEU A . n 
A 1 205 TYR 205 205 205 TYR TYR A . n 
A 1 206 LEU 206 206 206 LEU LEU A . n 
A 1 207 LYS 207 207 207 LYS LYS A . n 
A 1 208 ASN 208 208 208 ASN ASN A . n 
A 1 209 THR 209 209 209 THR THR A . n 
A 1 210 LEU 210 210 210 LEU LEU A . n 
A 1 211 ARG 211 211 211 ARG ARG A . n 
A 1 212 ILE 212 212 212 ILE ILE A . n 
A 1 213 ILE 213 213 213 ILE ILE A . n 
A 1 214 SER 214 214 214 SER SER A . n 
A 1 215 ASP 215 215 215 ASP ASP A . n 
A 1 216 ALA 216 216 216 ALA ALA A . n 
A 1 217 SER 217 217 217 SER SER A . n 
A 1 218 GLY 218 218 218 GLY GLY A . n 
A 1 219 THR 219 219 219 THR THR A . n 
A 1 220 PRO 220 220 220 PRO PRO A . n 
A 1 221 ILE 221 221 221 ILE ILE A . n 
A 1 222 PRO 222 222 222 PRO PRO A . n 
A 1 223 VAL 223 223 223 VAL VAL A . n 
A 1 224 LEU 224 224 224 LEU LEU A . n 
A 1 225 PRO 225 225 225 PRO PRO A . n 
A 1 226 ALA 226 226 226 ALA ALA A . n 
A 1 227 VAL 227 227 227 VAL VAL A . n 
A 1 228 ASP 228 228 228 ASP ASP A . n 
A 1 229 VAL 229 229 229 VAL VAL A . n 
A 1 230 SER 230 230 230 SER SER A . n 
A 1 231 GLY 231 231 231 GLY GLY A . n 
A 1 232 GLU 232 232 232 GLU GLU A . n 
A 1 233 PRO 233 233 233 PRO PRO A . n 
A 1 234 LEU 234 234 234 LEU LEU A . n 
A 1 235 ASP 235 235 235 ASP ASP A . n 
A 1 236 LEU 236 236 236 LEU LEU A . n 
A 1 237 SER 237 237 237 SER SER A . n 
A 1 238 TYR 238 238 238 TYR TYR A . n 
A 1 239 ALA 239 239 239 ALA ALA A . n 
A 1 240 HIS 240 240 240 HIS HIS A . n 
A 1 241 LEU 241 241 241 LEU LEU A . n 
A 1 242 ARG 242 242 242 ARG ARG A . n 
A 1 243 ASN 243 243 243 ASN ASN A . n 
A 1 244 PHE 244 244 244 PHE PHE A . n 
A 1 245 SER 245 245 245 SER SER A . n 
A 1 246 PRO 246 246 246 PRO PRO A . n 
A 1 247 ILE 247 247 247 ILE ILE A . n 
A 1 248 HIS 248 248 248 HIS HIS A . n 
A 1 249 CYS 249 249 249 CYS CYS A . n 
A 1 250 GLU 250 250 250 GLU GLU A . n 
A 1 251 TYR 251 251 251 TYR TYR A . n 
A 1 252 LEU 252 252 252 LEU LEU A . n 
A 1 253 ARG 253 253 253 ARG ARG A . n 
A 1 254 ASN 254 254 254 ASN ASN A . n 
A 1 255 MET 255 255 255 MET MET A . n 
A 1 256 GLY 256 256 256 GLY GLY A . n 
A 1 257 VAL 257 257 257 VAL VAL A . n 
A 1 258 ALA 258 258 258 ALA ALA A . n 
A 1 259 ALA 259 259 259 ALA ALA A . n 
A 1 260 SER 260 260 260 SER SER A . n 
A 1 261 MET 261 261 261 MET MET A . n 
A 1 262 SER 262 262 262 SER SER A . n 
A 1 263 ILE 263 263 263 ILE ILE A . n 
A 1 264 SER 264 264 264 SER SER A . n 
A 1 265 VAL 265 265 265 VAL VAL A . n 
A 1 266 ILE 266 266 266 ILE ILE A . n 
A 1 267 VAL 267 267 267 VAL VAL A . n 
A 1 268 ASP 268 268 268 ASP ASP A . n 
A 1 269 ASP 269 269 269 ASP ASP A . n 
A 1 270 ALA 270 270 270 ALA ALA A . n 
A 1 271 LEU 271 271 271 LEU LEU A . n 
A 1 272 TRP 272 272 272 TRP TRP A . n 
A 1 273 GLY 273 273 273 GLY GLY A . n 
A 1 274 LEU 274 274 274 LEU LEU A . n 
A 1 275 ILE 275 275 275 ILE ILE A . n 
A 1 276 VAL 276 276 276 VAL VAL A . n 
A 1 277 CYS 277 277 277 CYS CYS A . n 
A 1 278 HIS 278 278 278 HIS HIS A . n 
A 1 279 HIS 279 279 279 HIS HIS A . n 
A 1 280 CYS 280 280 280 CYS CYS A . n 
A 1 281 SER 281 281 281 SER SER A . n 
A 1 282 PRO 282 282 282 PRO PRO A . n 
A 1 283 ARG 283 283 283 ARG ARG A . n 
A 1 284 VAL 284 284 284 VAL VAL A . n 
A 1 285 LEU 285 285 285 LEU LEU A . n 
A 1 286 SER 286 286 286 SER SER A . n 
A 1 287 MET 287 287 287 MET MET A . n 
A 1 288 PRO 288 288 288 PRO PRO A . n 
A 1 289 VAL 289 289 289 VAL VAL A . n 
A 1 290 ARG 290 290 290 ARG ARG A . n 
A 1 291 ILE 291 291 291 ILE ILE A . n 
A 1 292 ALA 292 292 292 ALA ALA A . n 
A 1 293 ALA 293 293 293 ALA ALA A . n 
A 1 294 ALA 294 294 294 ALA ALA A . n 
A 1 295 MET 295 295 295 MET MET A . n 
A 1 296 PHE 296 296 296 PHE PHE A . n 
A 1 297 GLY 297 297 297 GLY GLY A . n 
A 1 298 GLU 298 298 298 GLU GLU A . n 
A 1 299 PHE 299 299 299 PHE PHE A . n 
A 1 300 PHE 300 300 300 PHE PHE A . n 
A 1 301 SER 301 301 301 SER SER A . n 
A 1 302 MET 302 302 302 MET MET A . n 
A 1 303 PHE 303 303 303 PHE PHE A . n 
A 1 304 LEU 304 304 304 LEU LEU A . n 
A 1 305 GLN 305 305 305 GLN GLN A . n 
A 1 306 VAL 306 306 306 VAL VAL A . n 
A 1 307 LEU 307 307 307 LEU LEU A . n 
A 1 308 LYS 308 308 308 LYS LYS A . n 
A 1 309 GLN 309 309 309 GLN GLN A . n 
A 1 310 LYS 310 310 310 LYS LYS A . n 
A 1 311 ARG 311 311 311 ARG ARG A . n 
A 1 312 ARG 312 312 312 ARG ARG A . n 
A 1 313 LEU 313 313 313 LEU LEU A . n 
A 1 314 ASP 314 314 314 ASP ASP A . n 
A 1 315 THR 315 315 315 THR THR A . n 
A 1 316 ILE 316 316 316 ILE ILE A . n 
A 1 317 ASN 317 317 317 ASN ASN A . n 
A 1 318 HIS 318 318 318 HIS HIS A . n 
A 1 319 ALA 319 319 319 ALA ALA A . n 
A 1 320 HIS 320 320 320 HIS HIS A . n 
A 1 321 ALA 321 321 321 ALA ALA A . n 
A 1 322 ALA 322 322 322 ALA ALA A . n 
A 1 323 LEU 323 323 323 LEU LEU A . n 
A 1 324 ASP 324 324 324 ASP ASP A . n 
A 1 325 ARG 325 325 325 ARG ARG A . n 
A 1 326 PHE 326 326 326 PHE PHE A . n 
A 1 327 LEU 327 327 327 LEU LEU A . n 
A 1 328 ARG 328 328 328 ARG ARG A . n 
A 1 329 LEU 329 329 329 LEU LEU A . n 
A 1 330 ALA 330 330 330 ALA ALA A . n 
A 1 331 ALA 331 331 331 ALA ALA A . n 
A 1 332 HIS 332 332 332 HIS HIS A . n 
A 1 333 ARG 333 333 333 ARG ARG A . n 
A 1 334 ALA 334 334 334 ALA ALA A . n 
A 1 335 ASN 335 335 335 ASN ASN A . n 
A 1 336 LEU 336 336 336 LEU LEU A . n 
A 1 337 GLU 337 337 337 GLU GLU A . n 
A 1 338 GLU 338 338 338 GLU GLU A . n 
A 1 339 LEU 339 339 339 LEU LEU A . n 
A 1 340 LEU 340 340 340 LEU LEU A . n 
A 1 341 VAL 341 341 341 VAL VAL A . n 
A 1 342 ASP 342 342 342 ASP ASP A . n 
A 1 343 SER 343 343 343 SER SER A . n 
A 1 344 PHE 344 344 344 PHE PHE A . n 
A 1 345 GLN 345 345 345 GLN GLN A . n 
A 1 346 ASP 346 346 346 ASP ASP A . n 
A 1 347 PHE 347 347 347 PHE PHE A . n 
A 1 348 ALA 348 348 348 ALA ALA A . n 
A 1 349 ARG 349 349 349 ARG ARG A . n 
A 1 350 LEU 350 350 350 LEU LEU A . n 
A 1 351 ILE 351 351 351 ILE ILE A . n 
A 1 352 PRO 352 352 352 PRO PRO A . n 
A 1 353 CYS 353 353 353 CYS CYS A . n 
A 1 354 ASP 354 354 354 ASP ASP A . n 
A 1 355 GLY 355 355 355 GLY GLY A . n 
A 1 356 VAL 356 356 356 VAL VAL A . n 
A 1 357 GLY 357 357 357 GLY GLY A . n 
A 1 358 LEU 358 358 358 LEU LEU A . n 
A 1 359 TRP 359 359 359 TRP TRP A . n 
A 1 360 VAL 360 360 360 VAL VAL A . n 
A 1 361 GLY 361 361 361 GLY GLY A . n 
A 1 362 ASN 362 362 362 ASN ASN A . n 
A 1 363 ASN 363 363 363 ASN ASN A . n 
A 1 364 TRP 364 364 364 TRP TRP A . n 
A 1 365 HIS 365 365 365 HIS HIS A . n 
A 1 366 GLY 366 366 366 GLY GLY A . n 
A 1 367 HIS 367 367 367 HIS HIS A . n 
A 1 368 GLY 368 368 368 GLY GLY A . n 
A 1 369 ALA 369 369 369 ALA ALA A . n 
A 1 370 THR 370 370 370 THR THR A . n 
A 1 371 PRO 371 371 371 PRO PRO A . n 
A 1 372 PRO 372 372 372 PRO PRO A . n 
A 1 373 HIS 373 373 373 HIS HIS A . n 
A 1 374 ASP 374 374 374 ASP ASP A . n 
A 1 375 ALA 375 375 375 ALA ALA A . n 
A 1 376 ILE 376 376 376 ILE ILE A . n 
A 1 377 PRO 377 377 377 PRO PRO A . n 
A 1 378 ARG 378 378 378 ARG ARG A . n 
A 1 379 LEU 379 379 379 LEU LEU A . n 
A 1 380 ALA 380 380 380 ALA ALA A . n 
A 1 381 ARG 381 381 381 ARG ARG A . n 
A 1 382 PHE 382 382 382 PHE PHE A . n 
A 1 383 VAL 383 383 383 VAL VAL A . n 
A 1 384 ALA 384 384 384 ALA ALA A . n 
A 1 385 SER 385 385 385 SER SER A . n 
A 1 386 VAL 386 386 386 VAL VAL A . n 
A 1 387 SER 387 387 387 SER SER A . n 
A 1 388 GLU 388 388 388 GLU GLU A . n 
A 1 389 GLY 389 389 389 GLY GLY A . n 
A 1 390 ARG 390 390 390 ARG ARG A . n 
A 1 391 VAL 391 391 391 VAL VAL A . n 
A 1 392 TRP 392 392 392 TRP TRP A . n 
A 1 393 ALA 393 393 393 ALA ALA A . n 
A 1 394 THR 394 394 394 THR THR A . n 
A 1 395 HIS 395 395 395 HIS HIS A . n 
A 1 396 ALA 396 396 396 ALA ALA A . n 
A 1 397 LEU 397 397 397 LEU LEU A . n 
A 1 398 SER 398 398 398 SER SER A . n 
A 1 399 GLN 399 399 399 GLN GLN A . n 
A 1 400 ALA 400 400 400 ALA ALA A . n 
A 1 401 ILE 401 401 401 ILE ILE A . n 
A 1 402 PRO 402 402 402 PRO PRO A . n 
A 1 403 GLU 403 403 403 GLU GLU A . n 
A 1 404 ALA 404 404 404 ALA ALA A . n 
A 1 405 GLU 405 405 405 GLU GLU A . n 
A 1 406 ILE 406 406 406 ILE ILE A . n 
A 1 407 TYR 407 407 407 TYR TYR A . n 
A 1 408 ALA 408 408 408 ALA ALA A . n 
A 1 409 ASP 409 409 409 ASP ASP A . n 
A 1 410 THR 410 410 410 THR THR A . n 
A 1 411 ALA 411 411 411 ALA ALA A . n 
A 1 412 ALA 412 412 412 ALA ALA A . n 
A 1 413 GLY 413 413 413 GLY GLY A . n 
A 1 414 MET 414 414 414 MET MET A . n 
A 1 415 LEU 415 415 415 LEU LEU A . n 
A 1 416 ALA 416 416 416 ALA ALA A . n 
A 1 417 ILE 417 417 417 ILE ILE A . n 
A 1 418 PRO 418 418 418 PRO PRO A . n 
A 1 419 ILE 419 419 419 ILE ILE A . n 
A 1 420 SER 420 420 420 SER SER A . n 
A 1 421 GLN 421 421 421 GLN GLN A . n 
A 1 422 VAL 422 422 422 VAL VAL A . n 
A 1 423 LYS 423 423 423 LYS LYS A . n 
A 1 424 SER 424 424 424 SER SER A . n 
A 1 425 ASP 425 425 425 ASP ASP A . n 
A 1 426 TYR 426 426 426 TYR TYR A . n 
A 1 427 LEU 427 427 427 LEU LEU A . n 
A 1 428 LEU 428 428 428 LEU LEU A . n 
A 1 429 PHE 429 429 429 PHE PHE A . n 
A 1 430 PHE 430 430 430 PHE PHE A . n 
A 1 431 ARG 431 431 431 ARG ARG A . n 
A 1 432 LYS 432 432 432 LYS LYS A . n 
A 1 433 GLU 433 433 433 GLU GLU A . n 
A 1 434 ILE 434 434 434 ILE ILE A . n 
A 1 435 VAL 435 435 435 VAL VAL A . n 
A 1 436 GLN 436 436 436 GLN GLN A . n 
A 1 437 ASN 437 437 437 ASN ASN A . n 
A 1 438 LEU 438 438 438 LEU LEU A . n 
A 1 439 ASN 439 439 439 ASN ASN A . n 
A 1 440 TRP 440 440 440 TRP TRP A . n 
A 1 441 ALA 441 441 441 ALA ALA A . n 
A 1 442 GLY 442 442 442 GLY GLY A . n 
A 1 443 ASN 443 443 443 ASN ASN A . n 
A 1 444 PRO 444 444 444 PRO PRO A . n 
A 1 445 GLU 445 445 445 GLU GLU A . n 
A 1 446 LYS 446 446 446 LYS LYS A . n 
A 1 447 SER 447 447 447 SER SER A . n 
A 1 448 TYR 448 448 448 TYR TYR A . n 
A 1 449 GLU 449 449 449 GLU GLU A . n 
A 1 450 THR 450 450 450 THR THR A . n 
A 1 451 GLY 451 451 451 GLY GLY A . n 
A 1 452 PRO 452 452 452 PRO PRO A . n 
A 1 453 MET 453 453 453 MET MET A . n 
A 1 454 GLY 454 454 454 GLY GLY A . n 
A 1 455 ASP 455 455 455 ASP ASP A . n 
A 1 456 ARG 456 456 456 ARG ARG A . n 
A 1 457 LEU 457 457 457 LEU LEU A . n 
A 1 458 THR 458 458 458 THR THR A . n 
A 1 459 PRO 459 459 459 PRO PRO A . n 
A 1 460 ARG 460 460 460 ARG ARG A . n 
A 1 461 LYS 461 461 461 LYS LYS A . n 
A 1 462 SER 462 462 462 SER SER A . n 
A 1 463 PHE 463 463 463 PHE PHE A . n 
A 1 464 ALA 464 464 464 ALA ALA A . n 
A 1 465 ILE 465 465 465 ILE ILE A . n 
A 1 466 TRP 466 466 466 TRP TRP A . n 
A 1 467 LYS 467 467 467 LYS LYS A . n 
A 1 468 GLU 468 468 468 GLU GLU A . n 
A 1 469 SER 469 469 469 SER SER A . n 
A 1 470 VAL 470 470 470 VAL VAL A . n 
A 1 471 ARG 471 471 471 ARG ARG A . n 
A 1 472 LEU 472 472 472 LEU LEU A . n 
A 1 473 GLN 473 473 473 GLN GLN A . n 
A 1 474 ALA 474 474 474 ALA ALA A . n 
A 1 475 GLN 475 475 475 GLN GLN A . n 
A 1 476 PRO 476 476 476 PRO PRO A . n 
A 1 477 TRP 477 477 477 TRP TRP A . n 
A 1 478 SER 478 478 478 SER SER A . n 
A 1 479 GLU 479 479 479 GLU GLU A . n 
A 1 480 ALA 480 480 480 ALA ALA A . n 
A 1 481 ASP 481 481 481 ASP ASP A . n 
A 1 482 ARG 482 482 482 ARG ARG A . n 
A 1 483 GLU 483 483 483 GLU GLU A . n 
A 1 484 ILE 484 484 484 ILE ILE A . n 
A 1 485 ALA 485 485 485 ALA ALA A . n 
A 1 486 GLU 486 486 486 GLU GLU A . n 
A 1 487 THR 487 487 487 THR THR A . n 
A 1 488 ALA 488 488 488 ALA ALA A . n 
A 1 489 ARG 489 489 489 ARG ARG A . n 
A 1 490 ILE 490 490 490 ILE ILE A . n 
A 1 491 ALA 491 491 491 ALA ALA A . n 
A 1 492 LEU 492 492 492 LEU LEU A . n 
A 1 493 VAL 493 493 493 VAL VAL A . n 
A 1 494 GLY 494 494 494 GLY GLY A . n 
A 1 495 VAL 495 495 495 VAL VAL A . n 
A 1 496 ALA 496 496 496 ALA ALA A . n 
A 1 497 PHE 497 497 497 PHE PHE A . n 
A 1 498 HIS 498 498 498 HIS HIS A . n 
A 1 499 HIS 499 499 499 HIS HIS A . n 
A 1 500 SER 500 500 500 SER SER A . n 
A 1 501 GLU 501 501 ?   ?   ?   A . n 
A 1 502 LEU 502 502 ?   ?   ?   A . n 
A 1 503 MET 503 503 ?   ?   ?   A . n 
A 1 504 ALA 504 504 ?   ?   ?   A . n 
A 1 505 GLY 505 505 ?   ?   ?   A . n 
A 1 506 LEU 506 506 ?   ?   ?   A . n 
A 1 507 GLU 507 507 ?   ?   ?   A . n 
A 1 508 TYR 508 508 ?   ?   ?   A . n 
A 1 509 LYS 509 509 ?   ?   ?   A . n 
A 1 510 HIS 510 510 ?   ?   ?   A . n 
A 1 511 HIS 511 511 ?   ?   ?   A . n 
A 1 512 HIS 512 512 ?   ?   ?   A . n 
A 1 513 HIS 513 513 ?   ?   ?   A . n 
A 1 514 HIS 514 514 ?   ?   ?   A . n 
A 1 515 HIS 515 515 ?   ?   ?   A . n 
B 1 1   MET 1   1   ?   ?   ?   B . n 
B 1 2   ALA 2   2   ?   ?   ?   B . n 
B 1 3   SER 3   3   ?   ?   ?   B . n 
B 1 4   THR 4   4   ?   ?   ?   B . n 
B 1 5   ASP 5   5   5   ASP ASP B . n 
B 1 6   TYR 6   6   6   TYR TYR B . n 
B 1 7   HIS 7   7   7   HIS HIS B . n 
B 1 8   VAL 8   8   8   VAL VAL B . n 
B 1 9   ASP 9   9   9   ASP ASP B . n 
B 1 10  LEU 10  10  10  LEU LEU B . n 
B 1 11  THR 11  11  11  THR THR B . n 
B 1 12  ASN 12  12  12  ASN ASN B . n 
B 1 13  CYS 13  13  13  CYS CYS B . n 
B 1 14  ASP 14  14  14  ASP ASP B . n 
B 1 15  ARG 15  15  15  ARG ARG B . n 
B 1 16  GLU 16  16  16  GLU GLU B . n 
B 1 17  PRO 17  17  17  PRO PRO B . n 
B 1 18  ILE 18  18  18  ILE ILE B . n 
B 1 19  HIS 19  19  19  HIS HIS B . n 
B 1 20  ILE 20  20  20  ILE ILE B . n 
B 1 21  PRO 21  21  21  PRO PRO B . n 
B 1 22  GLY 22  22  22  GLY GLY B . n 
B 1 23  TYR 23  23  23  TYR TYR B . n 
B 1 24  ILE 24  24  24  ILE ILE B . n 
B 1 25  GLN 25  25  25  GLN GLN B . n 
B 1 26  PRO 26  26  26  PRO PRO B . n 
B 1 27  HIS 27  27  27  HIS HIS B . n 
B 1 28  GLY 28  28  28  GLY GLY B . n 
B 1 29  CYS 29  29  29  CYS CYS B . n 
B 1 30  LEU 30  30  30  LEU LEU B . n 
B 1 31  ILE 31  31  31  ILE ILE B . n 
B 1 32  ALA 32  32  32  ALA ALA B . n 
B 1 33  CYS 33  33  33  CYS CYS B . n 
B 1 34  ASP 34  34  34  ASP ASP B . n 
B 1 35  ASN 35  35  35  ASN ASN B . n 
B 1 36  ALA 36  36  36  ALA ALA B . n 
B 1 37  MET 37  37  37  MET MET B . n 
B 1 38  ARG 38  38  38  ARG ARG B . n 
B 1 39  MET 39  39  39  MET MET B . n 
B 1 40  VAL 40  40  40  VAL VAL B . n 
B 1 41  LEU 41  41  41  LEU LEU B . n 
B 1 42  ARG 42  42  42  ARG ARG B . n 
B 1 43  HIS 43  43  43  HIS HIS B . n 
B 1 44  SER 44  44  44  SER SER B . n 
B 1 45  GLU 45  45  45  GLU GLU B . n 
B 1 46  ASN 46  46  46  ASN ASN B . n 
B 1 47  CYS 47  47  47  CYS CYS B . n 
B 1 48  GLY 48  48  48  GLY GLY B . n 
B 1 49  GLU 49  49  49  GLU GLU B . n 
B 1 50  LEU 50  50  50  LEU LEU B . n 
B 1 51  LEU 51  51  51  LEU LEU B . n 
B 1 52  GLY 52  52  52  GLY GLY B . n 
B 1 53  LEU 53  53  53  LEU LEU B . n 
B 1 54  GLU 54  54  54  GLU GLU B . n 
B 1 55  GLY 55  55  55  GLY GLY B . n 
B 1 56  ASP 56  56  56  ASP ASP B . n 
B 1 57  LEU 57  57  57  LEU LEU B . n 
B 1 58  ASN 58  58  58  ASN ASN B . n 
B 1 59  GLY 59  59  59  GLY GLY B . n 
B 1 60  ARG 60  60  60  ARG ARG B . n 
B 1 61  THR 61  61  61  THR THR B . n 
B 1 62  ALA 62  62  62  ALA ALA B . n 
B 1 63  GLU 63  63  63  GLU GLU B . n 
B 1 64  ASP 64  64  64  ASP ASP B . n 
B 1 65  VAL 65  65  65  VAL VAL B . n 
B 1 66  LEU 66  66  66  LEU LEU B . n 
B 1 67  GLY 67  67  67  GLY GLY B . n 
B 1 68  LYS 68  68  68  LYS LYS B . n 
B 1 69  ARG 69  69  69  ARG ARG B . n 
B 1 70  LEU 70  70  70  LEU LEU B . n 
B 1 71  VAL 71  71  71  VAL VAL B . n 
B 1 72  HIS 72  72  72  HIS HIS B . n 
B 1 73  ASP 73  73  73  ASP ASP B . n 
B 1 74  LEU 74  74  74  LEU LEU B . n 
B 1 75  ARG 75  75  75  ARG ARG B . n 
B 1 76  ASN 76  76  76  ASN ASN B . n 
B 1 77  ALA 77  77  77  ALA ALA B . n 
B 1 78  LEU 78  78  78  LEU LEU B . n 
B 1 79  THR 79  79  79  THR THR B . n 
B 1 80  VAL 80  80  80  VAL VAL B . n 
B 1 81  THR 81  81  ?   ?   ?   B . n 
B 1 82  GLY 82  82  ?   ?   ?   B . n 
B 1 83  LYS 83  83  ?   ?   ?   B . n 
B 1 84  THR 84  84  ?   ?   ?   B . n 
B 1 85  THR 85  85  85  THR THR B . n 
B 1 86  ARG 86  86  86  ARG ARG B . n 
B 1 87  PRO 87  87  87  PRO PRO B . n 
B 1 88  ALA 88  88  88  ALA ALA B . n 
B 1 89  MET 89  89  89  MET MET B . n 
B 1 90  LEU 90  90  90  LEU LEU B . n 
B 1 91  PRO 91  91  91  PRO PRO B . n 
B 1 92  ALA 92  92  92  ALA ALA B . n 
B 1 93  MET 93  93  93  MET MET B . n 
B 1 94  GLU 94  94  94  GLU GLU B . n 
B 1 95  THR 95  95  95  THR THR B . n 
B 1 96  SER 96  96  96  SER SER B . n 
B 1 97  ASP 97  97  97  ASP ASP B . n 
B 1 98  GLY 98  98  98  GLY GLY B . n 
B 1 99  ARG 99  99  99  ARG ARG B . n 
B 1 100 SER 100 100 100 SER SER B . n 
B 1 101 PHE 101 101 101 PHE PHE B . n 
B 1 102 ASP 102 102 102 ASP ASP B . n 
B 1 103 ILE 103 103 103 ILE ILE B . n 
B 1 104 SER 104 104 104 SER SER B . n 
B 1 105 LEU 105 105 105 LEU LEU B . n 
B 1 106 HIS 106 106 106 HIS HIS B . n 
B 1 107 ARG 107 107 107 ARG ARG B . n 
B 1 108 TYR 108 108 108 TYR TYR B . n 
B 1 109 LYS 109 109 109 LYS LYS B . n 
B 1 110 SER 110 110 110 SER SER B . n 
B 1 111 THR 111 111 111 THR THR B . n 
B 1 112 THR 112 112 112 THR THR B . n 
B 1 113 ILE 113 113 113 ILE ILE B . n 
B 1 114 ILE 114 114 114 ILE ILE B . n 
B 1 115 GLU 115 115 115 GLU GLU B . n 
B 1 116 PHE 116 116 116 PHE PHE B . n 
B 1 117 GLU 117 117 117 GLU GLU B . n 
B 1 118 PRO 118 118 118 PRO PRO B . n 
B 1 119 SER 119 119 119 SER SER B . n 
B 1 120 ASP 120 120 120 ASP ASP B . n 
B 1 121 SER 121 121 121 SER SER B . n 
B 1 122 ASP 122 122 122 ASP ASP B . n 
B 1 123 THR 123 123 123 THR THR B . n 
B 1 124 GLN 124 124 124 GLN GLN B . n 
B 1 125 PRO 125 125 125 PRO PRO B . n 
B 1 126 LEU 126 126 126 LEU LEU B . n 
B 1 127 GLY 127 127 127 GLY GLY B . n 
B 1 128 THR 128 128 128 THR THR B . n 
B 1 129 ALA 129 129 129 ALA ALA B . n 
B 1 130 ARG 130 130 130 ARG ARG B . n 
B 1 131 LYS 131 131 131 LYS LYS B . n 
B 1 132 MET 132 132 132 MET MET B . n 
B 1 133 VAL 133 133 133 VAL VAL B . n 
B 1 134 ASP 134 134 134 ASP ASP B . n 
B 1 135 ARG 135 135 135 ARG ARG B . n 
B 1 136 ILE 136 136 136 ILE ILE B . n 
B 1 137 ARG 137 137 137 ARG ARG B . n 
B 1 138 GLU 138 138 138 GLU GLU B . n 
B 1 139 ALA 139 139 139 ALA ALA B . n 
B 1 140 ASP 140 140 140 ASP ASP B . n 
B 1 141 SER 141 141 141 SER SER B . n 
B 1 142 VAL 142 142 142 VAL VAL B . n 
B 1 143 GLU 143 143 143 GLU GLU B . n 
B 1 144 SER 144 144 144 SER SER B . n 
B 1 145 LEU 145 145 145 LEU LEU B . n 
B 1 146 ILE 146 146 146 ILE ILE B . n 
B 1 147 SER 147 147 147 SER SER B . n 
B 1 148 ARG 148 148 148 ARG ARG B . n 
B 1 149 THR 149 149 149 THR THR B . n 
B 1 150 THR 150 150 150 THR THR B . n 
B 1 151 ARG 151 151 151 ARG ARG B . n 
B 1 152 LEU 152 152 152 LEU LEU B . n 
B 1 153 VAL 153 153 153 VAL VAL B . n 
B 1 154 LYS 154 154 154 LYS LYS B . n 
B 1 155 ALA 155 155 155 ALA ALA B . n 
B 1 156 THR 156 156 156 THR THR B . n 
B 1 157 LEU 157 157 157 LEU LEU B . n 
B 1 158 GLY 158 158 158 GLY GLY B . n 
B 1 159 TYR 159 159 159 TYR TYR B . n 
B 1 160 ASP 160 160 160 ASP ASP B . n 
B 1 161 ARG 161 161 161 ARG ARG B . n 
B 1 162 VAL 162 162 162 VAL VAL B . n 
B 1 163 LEU 163 163 163 LEU LEU B . n 
B 1 164 ILE 164 164 164 ILE ILE B . n 
B 1 165 TYR 165 165 165 TYR TYR B . n 
B 1 166 ARG 166 166 166 ARG ARG B . n 
B 1 167 PHE 167 167 167 PHE PHE B . n 
B 1 168 GLU 168 168 168 GLU GLU B . n 
B 1 169 GLU 169 169 169 GLU GLU B . n 
B 1 170 ASP 170 170 170 ASP ASP B . n 
B 1 171 GLY 171 171 171 GLY GLY B . n 
B 1 172 ALA 172 172 172 ALA ALA B . n 
B 1 173 GLY 173 173 173 GLY GLY B . n 
B 1 174 LYS 174 174 174 LYS LYS B . n 
B 1 175 VAL 175 175 175 VAL VAL B . n 
B 1 176 VAL 176 176 176 VAL VAL B . n 
B 1 177 SER 177 177 177 SER SER B . n 
B 1 178 GLU 178 178 178 GLU GLU B . n 
B 1 179 ALA 179 179 179 ALA ALA B . n 
B 1 180 LYS 180 180 180 LYS LYS B . n 
B 1 181 GLN 181 181 181 GLN GLN B . n 
B 1 182 PRO 182 182 182 PRO PRO B . n 
B 1 183 GLU 183 183 183 GLU GLU B . n 
B 1 184 LEU 184 184 184 LEU LEU B . n 
B 1 185 GLU 185 185 185 GLU GLU B . n 
B 1 186 SER 186 186 186 SER SER B . n 
B 1 187 PHE 187 187 187 PHE PHE B . n 
B 1 188 LEU 188 188 188 LEU LEU B . n 
B 1 189 GLY 189 189 189 GLY GLY B . n 
B 1 190 GLN 190 190 190 GLN GLN B . n 
B 1 191 TYR 191 191 191 TYR TYR B . n 
B 1 192 PHE 192 192 192 PHE PHE B . n 
B 1 193 PRO 193 193 193 PRO PRO B . n 
B 1 194 ALA 194 194 194 ALA ALA B . n 
B 1 195 SER 195 195 195 SER SER B . n 
B 1 196 ASP 196 196 196 ASP ASP B . n 
B 1 197 ILE 197 197 197 ILE ILE B . n 
B 1 198 PRO 198 198 198 PRO PRO B . n 
B 1 199 GLN 199 199 199 GLN GLN B . n 
B 1 200 GLN 200 200 200 GLN GLN B . n 
B 1 201 ALA 201 201 201 ALA ALA B . n 
B 1 202 ARG 202 202 202 ARG ARG B . n 
B 1 203 ALA 203 203 203 ALA ALA B . n 
B 1 204 LEU 204 204 204 LEU LEU B . n 
B 1 205 TYR 205 205 205 TYR TYR B . n 
B 1 206 LEU 206 206 206 LEU LEU B . n 
B 1 207 LYS 207 207 207 LYS LYS B . n 
B 1 208 ASN 208 208 208 ASN ASN B . n 
B 1 209 THR 209 209 209 THR THR B . n 
B 1 210 LEU 210 210 210 LEU LEU B . n 
B 1 211 ARG 211 211 211 ARG ARG B . n 
B 1 212 ILE 212 212 212 ILE ILE B . n 
B 1 213 ILE 213 213 213 ILE ILE B . n 
B 1 214 SER 214 214 214 SER SER B . n 
B 1 215 ASP 215 215 215 ASP ASP B . n 
B 1 216 ALA 216 216 216 ALA ALA B . n 
B 1 217 SER 217 217 217 SER SER B . n 
B 1 218 GLY 218 218 218 GLY GLY B . n 
B 1 219 THR 219 219 219 THR THR B . n 
B 1 220 PRO 220 220 220 PRO PRO B . n 
B 1 221 ILE 221 221 221 ILE ILE B . n 
B 1 222 PRO 222 222 222 PRO PRO B . n 
B 1 223 VAL 223 223 223 VAL VAL B . n 
B 1 224 LEU 224 224 224 LEU LEU B . n 
B 1 225 PRO 225 225 225 PRO PRO B . n 
B 1 226 ALA 226 226 226 ALA ALA B . n 
B 1 227 VAL 227 227 227 VAL VAL B . n 
B 1 228 ASP 228 228 228 ASP ASP B . n 
B 1 229 VAL 229 229 229 VAL VAL B . n 
B 1 230 SER 230 230 230 SER SER B . n 
B 1 231 GLY 231 231 231 GLY GLY B . n 
B 1 232 GLU 232 232 232 GLU GLU B . n 
B 1 233 PRO 233 233 233 PRO PRO B . n 
B 1 234 LEU 234 234 234 LEU LEU B . n 
B 1 235 ASP 235 235 235 ASP ASP B . n 
B 1 236 LEU 236 236 236 LEU LEU B . n 
B 1 237 SER 237 237 237 SER SER B . n 
B 1 238 TYR 238 238 238 TYR TYR B . n 
B 1 239 ALA 239 239 239 ALA ALA B . n 
B 1 240 HIS 240 240 240 HIS HIS B . n 
B 1 241 LEU 241 241 241 LEU LEU B . n 
B 1 242 ARG 242 242 242 ARG ARG B . n 
B 1 243 ASN 243 243 243 ASN ASN B . n 
B 1 244 PHE 244 244 244 PHE PHE B . n 
B 1 245 SER 245 245 245 SER SER B . n 
B 1 246 PRO 246 246 246 PRO PRO B . n 
B 1 247 ILE 247 247 247 ILE ILE B . n 
B 1 248 HIS 248 248 248 HIS HIS B . n 
B 1 249 CYS 249 249 249 CYS CYS B . n 
B 1 250 GLU 250 250 250 GLU GLU B . n 
B 1 251 TYR 251 251 251 TYR TYR B . n 
B 1 252 LEU 252 252 252 LEU LEU B . n 
B 1 253 ARG 253 253 253 ARG ARG B . n 
B 1 254 ASN 254 254 254 ASN ASN B . n 
B 1 255 MET 255 255 255 MET MET B . n 
B 1 256 GLY 256 256 256 GLY GLY B . n 
B 1 257 VAL 257 257 257 VAL VAL B . n 
B 1 258 ALA 258 258 258 ALA ALA B . n 
B 1 259 ALA 259 259 259 ALA ALA B . n 
B 1 260 SER 260 260 260 SER SER B . n 
B 1 261 MET 261 261 261 MET MET B . n 
B 1 262 SER 262 262 262 SER SER B . n 
B 1 263 ILE 263 263 263 ILE ILE B . n 
B 1 264 SER 264 264 264 SER SER B . n 
B 1 265 VAL 265 265 265 VAL VAL B . n 
B 1 266 ILE 266 266 266 ILE ILE B . n 
B 1 267 VAL 267 267 267 VAL VAL B . n 
B 1 268 ASP 268 268 268 ASP ASP B . n 
B 1 269 ASP 269 269 269 ASP ASP B . n 
B 1 270 ALA 270 270 270 ALA ALA B . n 
B 1 271 LEU 271 271 271 LEU LEU B . n 
B 1 272 TRP 272 272 272 TRP TRP B . n 
B 1 273 GLY 273 273 273 GLY GLY B . n 
B 1 274 LEU 274 274 274 LEU LEU B . n 
B 1 275 ILE 275 275 275 ILE ILE B . n 
B 1 276 VAL 276 276 276 VAL VAL B . n 
B 1 277 CYS 277 277 277 CYS CYS B . n 
B 1 278 HIS 278 278 278 HIS HIS B . n 
B 1 279 HIS 279 279 279 HIS HIS B . n 
B 1 280 CYS 280 280 280 CYS CYS B . n 
B 1 281 SER 281 281 281 SER SER B . n 
B 1 282 PRO 282 282 282 PRO PRO B . n 
B 1 283 ARG 283 283 283 ARG ARG B . n 
B 1 284 VAL 284 284 284 VAL VAL B . n 
B 1 285 LEU 285 285 285 LEU LEU B . n 
B 1 286 SER 286 286 286 SER SER B . n 
B 1 287 MET 287 287 287 MET MET B . n 
B 1 288 PRO 288 288 288 PRO PRO B . n 
B 1 289 VAL 289 289 289 VAL VAL B . n 
B 1 290 ARG 290 290 290 ARG ARG B . n 
B 1 291 ILE 291 291 291 ILE ILE B . n 
B 1 292 ALA 292 292 292 ALA ALA B . n 
B 1 293 ALA 293 293 293 ALA ALA B . n 
B 1 294 ALA 294 294 294 ALA ALA B . n 
B 1 295 MET 295 295 295 MET MET B . n 
B 1 296 PHE 296 296 296 PHE PHE B . n 
B 1 297 GLY 297 297 297 GLY GLY B . n 
B 1 298 GLU 298 298 298 GLU GLU B . n 
B 1 299 PHE 299 299 299 PHE PHE B . n 
B 1 300 PHE 300 300 300 PHE PHE B . n 
B 1 301 SER 301 301 301 SER SER B . n 
B 1 302 MET 302 302 302 MET MET B . n 
B 1 303 PHE 303 303 303 PHE PHE B . n 
B 1 304 LEU 304 304 304 LEU LEU B . n 
B 1 305 GLN 305 305 305 GLN GLN B . n 
B 1 306 VAL 306 306 306 VAL VAL B . n 
B 1 307 LEU 307 307 307 LEU LEU B . n 
B 1 308 LYS 308 308 308 LYS LYS B . n 
B 1 309 GLN 309 309 309 GLN GLN B . n 
B 1 310 LYS 310 310 310 LYS LYS B . n 
B 1 311 ARG 311 311 311 ARG ARG B . n 
B 1 312 ARG 312 312 312 ARG ARG B . n 
B 1 313 LEU 313 313 313 LEU LEU B . n 
B 1 314 ASP 314 314 314 ASP ASP B . n 
B 1 315 THR 315 315 315 THR THR B . n 
B 1 316 ILE 316 316 316 ILE ILE B . n 
B 1 317 ASN 317 317 317 ASN ASN B . n 
B 1 318 HIS 318 318 318 HIS HIS B . n 
B 1 319 ALA 319 319 319 ALA ALA B . n 
B 1 320 HIS 320 320 320 HIS HIS B . n 
B 1 321 ALA 321 321 321 ALA ALA B . n 
B 1 322 ALA 322 322 322 ALA ALA B . n 
B 1 323 LEU 323 323 323 LEU LEU B . n 
B 1 324 ASP 324 324 324 ASP ASP B . n 
B 1 325 ARG 325 325 325 ARG ARG B . n 
B 1 326 PHE 326 326 326 PHE PHE B . n 
B 1 327 LEU 327 327 327 LEU LEU B . n 
B 1 328 ARG 328 328 328 ARG ARG B . n 
B 1 329 LEU 329 329 329 LEU LEU B . n 
B 1 330 ALA 330 330 330 ALA ALA B . n 
B 1 331 ALA 331 331 331 ALA ALA B . n 
B 1 332 HIS 332 332 332 HIS HIS B . n 
B 1 333 ARG 333 333 333 ARG ARG B . n 
B 1 334 ALA 334 334 334 ALA ALA B . n 
B 1 335 ASN 335 335 335 ASN ASN B . n 
B 1 336 LEU 336 336 336 LEU LEU B . n 
B 1 337 GLU 337 337 337 GLU GLU B . n 
B 1 338 GLU 338 338 338 GLU GLU B . n 
B 1 339 LEU 339 339 339 LEU LEU B . n 
B 1 340 LEU 340 340 340 LEU LEU B . n 
B 1 341 VAL 341 341 341 VAL VAL B . n 
B 1 342 ASP 342 342 342 ASP ASP B . n 
B 1 343 SER 343 343 343 SER SER B . n 
B 1 344 PHE 344 344 344 PHE PHE B . n 
B 1 345 GLN 345 345 345 GLN GLN B . n 
B 1 346 ASP 346 346 346 ASP ASP B . n 
B 1 347 PHE 347 347 347 PHE PHE B . n 
B 1 348 ALA 348 348 348 ALA ALA B . n 
B 1 349 ARG 349 349 349 ARG ARG B . n 
B 1 350 LEU 350 350 350 LEU LEU B . n 
B 1 351 ILE 351 351 351 ILE ILE B . n 
B 1 352 PRO 352 352 352 PRO PRO B . n 
B 1 353 CYS 353 353 353 CYS CYS B . n 
B 1 354 ASP 354 354 354 ASP ASP B . n 
B 1 355 GLY 355 355 355 GLY GLY B . n 
B 1 356 VAL 356 356 356 VAL VAL B . n 
B 1 357 GLY 357 357 357 GLY GLY B . n 
B 1 358 LEU 358 358 358 LEU LEU B . n 
B 1 359 TRP 359 359 359 TRP TRP B . n 
B 1 360 VAL 360 360 360 VAL VAL B . n 
B 1 361 GLY 361 361 361 GLY GLY B . n 
B 1 362 ASN 362 362 362 ASN ASN B . n 
B 1 363 ASN 363 363 363 ASN ASN B . n 
B 1 364 TRP 364 364 364 TRP TRP B . n 
B 1 365 HIS 365 365 365 HIS HIS B . n 
B 1 366 GLY 366 366 366 GLY GLY B . n 
B 1 367 HIS 367 367 367 HIS HIS B . n 
B 1 368 GLY 368 368 368 GLY GLY B . n 
B 1 369 ALA 369 369 369 ALA ALA B . n 
B 1 370 THR 370 370 370 THR THR B . n 
B 1 371 PRO 371 371 371 PRO PRO B . n 
B 1 372 PRO 372 372 372 PRO PRO B . n 
B 1 373 HIS 373 373 373 HIS HIS B . n 
B 1 374 ASP 374 374 374 ASP ASP B . n 
B 1 375 ALA 375 375 375 ALA ALA B . n 
B 1 376 ILE 376 376 376 ILE ILE B . n 
B 1 377 PRO 377 377 377 PRO PRO B . n 
B 1 378 ARG 378 378 378 ARG ARG B . n 
B 1 379 LEU 379 379 379 LEU LEU B . n 
B 1 380 ALA 380 380 380 ALA ALA B . n 
B 1 381 ARG 381 381 381 ARG ARG B . n 
B 1 382 PHE 382 382 382 PHE PHE B . n 
B 1 383 VAL 383 383 383 VAL VAL B . n 
B 1 384 ALA 384 384 384 ALA ALA B . n 
B 1 385 SER 385 385 385 SER SER B . n 
B 1 386 VAL 386 386 386 VAL VAL B . n 
B 1 387 SER 387 387 387 SER SER B . n 
B 1 388 GLU 388 388 388 GLU GLU B . n 
B 1 389 GLY 389 389 389 GLY GLY B . n 
B 1 390 ARG 390 390 390 ARG ARG B . n 
B 1 391 VAL 391 391 391 VAL VAL B . n 
B 1 392 TRP 392 392 392 TRP TRP B . n 
B 1 393 ALA 393 393 393 ALA ALA B . n 
B 1 394 THR 394 394 394 THR THR B . n 
B 1 395 HIS 395 395 395 HIS HIS B . n 
B 1 396 ALA 396 396 396 ALA ALA B . n 
B 1 397 LEU 397 397 397 LEU LEU B . n 
B 1 398 SER 398 398 398 SER SER B . n 
B 1 399 GLN 399 399 399 GLN GLN B . n 
B 1 400 ALA 400 400 400 ALA ALA B . n 
B 1 401 ILE 401 401 401 ILE ILE B . n 
B 1 402 PRO 402 402 402 PRO PRO B . n 
B 1 403 GLU 403 403 403 GLU GLU B . n 
B 1 404 ALA 404 404 404 ALA ALA B . n 
B 1 405 GLU 405 405 405 GLU GLU B . n 
B 1 406 ILE 406 406 406 ILE ILE B . n 
B 1 407 TYR 407 407 407 TYR TYR B . n 
B 1 408 ALA 408 408 408 ALA ALA B . n 
B 1 409 ASP 409 409 409 ASP ASP B . n 
B 1 410 THR 410 410 410 THR THR B . n 
B 1 411 ALA 411 411 411 ALA ALA B . n 
B 1 412 ALA 412 412 412 ALA ALA B . n 
B 1 413 GLY 413 413 413 GLY GLY B . n 
B 1 414 MET 414 414 414 MET MET B . n 
B 1 415 LEU 415 415 415 LEU LEU B . n 
B 1 416 ALA 416 416 416 ALA ALA B . n 
B 1 417 ILE 417 417 417 ILE ILE B . n 
B 1 418 PRO 418 418 418 PRO PRO B . n 
B 1 419 ILE 419 419 419 ILE ILE B . n 
B 1 420 SER 420 420 420 SER SER B . n 
B 1 421 GLN 421 421 421 GLN GLN B . n 
B 1 422 VAL 422 422 422 VAL VAL B . n 
B 1 423 LYS 423 423 423 LYS LYS B . n 
B 1 424 SER 424 424 424 SER SER B . n 
B 1 425 ASP 425 425 425 ASP ASP B . n 
B 1 426 TYR 426 426 426 TYR TYR B . n 
B 1 427 LEU 427 427 427 LEU LEU B . n 
B 1 428 LEU 428 428 428 LEU LEU B . n 
B 1 429 PHE 429 429 429 PHE PHE B . n 
B 1 430 PHE 430 430 430 PHE PHE B . n 
B 1 431 ARG 431 431 431 ARG ARG B . n 
B 1 432 LYS 432 432 432 LYS LYS B . n 
B 1 433 GLU 433 433 433 GLU GLU B . n 
B 1 434 ILE 434 434 434 ILE ILE B . n 
B 1 435 VAL 435 435 435 VAL VAL B . n 
B 1 436 GLN 436 436 436 GLN GLN B . n 
B 1 437 ASN 437 437 437 ASN ASN B . n 
B 1 438 LEU 438 438 438 LEU LEU B . n 
B 1 439 ASN 439 439 439 ASN ASN B . n 
B 1 440 TRP 440 440 440 TRP TRP B . n 
B 1 441 ALA 441 441 441 ALA ALA B . n 
B 1 442 GLY 442 442 442 GLY GLY B . n 
B 1 443 ASN 443 443 443 ASN ASN B . n 
B 1 444 PRO 444 444 444 PRO PRO B . n 
B 1 445 GLU 445 445 445 GLU GLU B . n 
B 1 446 LYS 446 446 446 LYS LYS B . n 
B 1 447 SER 447 447 447 SER SER B . n 
B 1 448 TYR 448 448 448 TYR TYR B . n 
B 1 449 GLU 449 449 449 GLU GLU B . n 
B 1 450 THR 450 450 450 THR THR B . n 
B 1 451 GLY 451 451 451 GLY GLY B . n 
B 1 452 PRO 452 452 452 PRO PRO B . n 
B 1 453 MET 453 453 453 MET MET B . n 
B 1 454 GLY 454 454 454 GLY GLY B . n 
B 1 455 ASP 455 455 455 ASP ASP B . n 
B 1 456 ARG 456 456 456 ARG ARG B . n 
B 1 457 LEU 457 457 457 LEU LEU B . n 
B 1 458 THR 458 458 458 THR THR B . n 
B 1 459 PRO 459 459 459 PRO PRO B . n 
B 1 460 ARG 460 460 460 ARG ARG B . n 
B 1 461 LYS 461 461 461 LYS LYS B . n 
B 1 462 SER 462 462 462 SER SER B . n 
B 1 463 PHE 463 463 463 PHE PHE B . n 
B 1 464 ALA 464 464 464 ALA ALA B . n 
B 1 465 ILE 465 465 465 ILE ILE B . n 
B 1 466 TRP 466 466 466 TRP TRP B . n 
B 1 467 LYS 467 467 467 LYS LYS B . n 
B 1 468 GLU 468 468 468 GLU GLU B . n 
B 1 469 SER 469 469 469 SER SER B . n 
B 1 470 VAL 470 470 470 VAL VAL B . n 
B 1 471 ARG 471 471 471 ARG ARG B . n 
B 1 472 LEU 472 472 472 LEU LEU B . n 
B 1 473 GLN 473 473 473 GLN GLN B . n 
B 1 474 ALA 474 474 474 ALA ALA B . n 
B 1 475 GLN 475 475 475 GLN GLN B . n 
B 1 476 PRO 476 476 476 PRO PRO B . n 
B 1 477 TRP 477 477 477 TRP TRP B . n 
B 1 478 SER 478 478 478 SER SER B . n 
B 1 479 GLU 479 479 479 GLU GLU B . n 
B 1 480 ALA 480 480 480 ALA ALA B . n 
B 1 481 ASP 481 481 481 ASP ASP B . n 
B 1 482 ARG 482 482 482 ARG ARG B . n 
B 1 483 GLU 483 483 483 GLU GLU B . n 
B 1 484 ILE 484 484 484 ILE ILE B . n 
B 1 485 ALA 485 485 485 ALA ALA B . n 
B 1 486 GLU 486 486 486 GLU GLU B . n 
B 1 487 THR 487 487 487 THR THR B . n 
B 1 488 ALA 488 488 488 ALA ALA B . n 
B 1 489 ARG 489 489 489 ARG ARG B . n 
B 1 490 ILE 490 490 490 ILE ILE B . n 
B 1 491 ALA 491 491 491 ALA ALA B . n 
B 1 492 LEU 492 492 492 LEU LEU B . n 
B 1 493 VAL 493 493 493 VAL VAL B . n 
B 1 494 GLY 494 494 494 GLY GLY B . n 
B 1 495 VAL 495 495 495 VAL VAL B . n 
B 1 496 ALA 496 496 496 ALA ALA B . n 
B 1 497 PHE 497 497 497 PHE PHE B . n 
B 1 498 HIS 498 498 498 HIS HIS B . n 
B 1 499 HIS 499 499 499 HIS HIS B . n 
B 1 500 SER 500 500 500 SER SER B . n 
B 1 501 GLU 501 501 ?   ?   ?   B . n 
B 1 502 LEU 502 502 ?   ?   ?   B . n 
B 1 503 MET 503 503 ?   ?   ?   B . n 
B 1 504 ALA 504 504 ?   ?   ?   B . n 
B 1 505 GLY 505 505 ?   ?   ?   B . n 
B 1 506 LEU 506 506 ?   ?   ?   B . n 
B 1 507 GLU 507 507 ?   ?   ?   B . n 
B 1 508 TYR 508 508 ?   ?   ?   B . n 
B 1 509 LYS 509 509 ?   ?   ?   B . n 
B 1 510 HIS 510 510 ?   ?   ?   B . n 
B 1 511 HIS 511 511 ?   ?   ?   B . n 
B 1 512 HIS 512 512 ?   ?   ?   B . n 
B 1 513 HIS 513 513 ?   ?   ?   B . n 
B 1 514 HIS 514 514 ?   ?   ?   B . n 
B 1 515 HIS 515 515 ?   ?   ?   B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        EL5 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   EL5 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 EL5 1  601 1   EL5 BLA A . 
D 3 SO4 1  602 6   SO4 SO4 A . 
E 3 SO4 1  603 11  SO4 SO4 A . 
F 2 EL5 1  601 2   EL5 BLA B . 
G 3 SO4 1  602 4   SO4 SO4 B . 
H 3 SO4 1  603 7   SO4 SO4 B . 
I 3 SO4 1  604 10  SO4 SO4 B . 
J 4 CL  1  605 1   CL  CL  B . 
K 5 HOH 1  701 57  HOH HOH A . 
K 5 HOH 2  702 19  HOH HOH A . 
K 5 HOH 3  703 189 HOH HOH A . 
K 5 HOH 4  704 206 HOH HOH A . 
K 5 HOH 5  705 53  HOH HOH A . 
K 5 HOH 6  706 22  HOH HOH A . 
K 5 HOH 7  707 66  HOH HOH A . 
K 5 HOH 8  708 31  HOH HOH A . 
K 5 HOH 9  709 120 HOH HOH A . 
K 5 HOH 10 710 33  HOH HOH A . 
K 5 HOH 11 711 60  HOH HOH A . 
K 5 HOH 12 712 182 HOH HOH A . 
K 5 HOH 13 713 3   HOH HOH A . 
K 5 HOH 14 714 96  HOH HOH A . 
K 5 HOH 15 715 54  HOH HOH A . 
K 5 HOH 16 716 67  HOH HOH A . 
K 5 HOH 17 717 62  HOH HOH A . 
K 5 HOH 18 718 102 HOH HOH A . 
K 5 HOH 19 719 34  HOH HOH A . 
K 5 HOH 20 720 2   HOH HOH A . 
K 5 HOH 21 721 199 HOH HOH A . 
K 5 HOH 22 722 45  HOH HOH A . 
K 5 HOH 23 723 15  HOH HOH A . 
K 5 HOH 24 724 170 HOH HOH A . 
K 5 HOH 25 725 18  HOH HOH A . 
K 5 HOH 26 726 139 HOH HOH A . 
K 5 HOH 27 727 81  HOH HOH A . 
K 5 HOH 28 728 198 HOH HOH A . 
K 5 HOH 29 729 37  HOH HOH A . 
K 5 HOH 30 730 200 HOH HOH A . 
K 5 HOH 31 731 87  HOH HOH A . 
K 5 HOH 32 732 146 HOH HOH A . 
K 5 HOH 33 733 41  HOH HOH A . 
K 5 HOH 34 734 1   HOH HOH A . 
K 5 HOH 35 735 38  HOH HOH A . 
K 5 HOH 36 736 166 HOH HOH A . 
K 5 HOH 37 737 23  HOH HOH A . 
K 5 HOH 38 738 144 HOH HOH A . 
K 5 HOH 39 739 51  HOH HOH A . 
K 5 HOH 40 740 32  HOH HOH A . 
K 5 HOH 41 741 185 HOH HOH A . 
K 5 HOH 42 742 203 HOH HOH A . 
K 5 HOH 43 743 197 HOH HOH A . 
K 5 HOH 44 744 75  HOH HOH A . 
K 5 HOH 45 745 204 HOH HOH A . 
K 5 HOH 46 746 167 HOH HOH A . 
K 5 HOH 47 747 100 HOH HOH A . 
K 5 HOH 48 748 168 HOH HOH A . 
K 5 HOH 49 749 205 HOH HOH A . 
K 5 HOH 50 750 148 HOH HOH A . 
K 5 HOH 51 751 184 HOH HOH A . 
K 5 HOH 52 752 169 HOH HOH A . 
K 5 HOH 53 753 181 HOH HOH A . 
L 5 HOH 1  701 13  HOH HOH B . 
L 5 HOH 2  702 127 HOH HOH B . 
L 5 HOH 3  703 172 HOH HOH B . 
L 5 HOH 4  704 11  HOH HOH B . 
L 5 HOH 5  705 190 HOH HOH B . 
L 5 HOH 6  706 128 HOH HOH B . 
L 5 HOH 7  707 25  HOH HOH B . 
L 5 HOH 8  708 117 HOH HOH B . 
L 5 HOH 9  709 21  HOH HOH B . 
L 5 HOH 10 710 47  HOH HOH B . 
L 5 HOH 11 711 10  HOH HOH B . 
L 5 HOH 12 712 20  HOH HOH B . 
L 5 HOH 13 713 65  HOH HOH B . 
L 5 HOH 14 714 202 HOH HOH B . 
L 5 HOH 15 715 58  HOH HOH B . 
L 5 HOH 16 716 14  HOH HOH B . 
L 5 HOH 17 717 158 HOH HOH B . 
L 5 HOH 18 718 194 HOH HOH B . 
L 5 HOH 19 719 196 HOH HOH B . 
L 5 HOH 20 720 28  HOH HOH B . 
L 5 HOH 21 721 115 HOH HOH B . 
L 5 HOH 22 722 173 HOH HOH B . 
L 5 HOH 23 723 85  HOH HOH B . 
L 5 HOH 24 724 129 HOH HOH B . 
L 5 HOH 25 725 43  HOH HOH B . 
L 5 HOH 26 726 178 HOH HOH B . 
L 5 HOH 27 727 160 HOH HOH B . 
L 5 HOH 28 728 123 HOH HOH B . 
L 5 HOH 29 729 59  HOH HOH B . 
L 5 HOH 30 730 195 HOH HOH B . 
L 5 HOH 31 731 171 HOH HOH B . 
L 5 HOH 32 732 192 HOH HOH B . 
L 5 HOH 33 733 124 HOH HOH B . 
L 5 HOH 34 734 164 HOH HOH B . 
L 5 HOH 35 735 175 HOH HOH B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1   1 Y 1 A ARG 15  ? CG  ? A ARG 15  CG  
2   1 Y 1 A ARG 15  ? CD  ? A ARG 15  CD  
3   1 Y 1 A ARG 15  ? NE  ? A ARG 15  NE  
4   1 Y 1 A ARG 15  ? CZ  ? A ARG 15  CZ  
5   1 Y 1 A ARG 15  ? NH1 ? A ARG 15  NH1 
6   1 Y 1 A ARG 15  ? NH2 ? A ARG 15  NH2 
7   1 Y 1 A ARG 38  ? CG  ? A ARG 38  CG  
8   1 Y 1 A ARG 38  ? CD  ? A ARG 38  CD  
9   1 Y 1 A ARG 38  ? NE  ? A ARG 38  NE  
10  1 Y 1 A ARG 38  ? CZ  ? A ARG 38  CZ  
11  1 Y 1 A ARG 38  ? NH1 ? A ARG 38  NH1 
12  1 Y 1 A ARG 38  ? NH2 ? A ARG 38  NH2 
13  1 Y 1 A GLU 54  ? CG  ? A GLU 54  CG  
14  1 Y 1 A GLU 54  ? CD  ? A GLU 54  CD  
15  1 Y 1 A GLU 54  ? OE1 ? A GLU 54  OE1 
16  1 Y 1 A GLU 54  ? OE2 ? A GLU 54  OE2 
17  1 Y 1 A ASP 64  ? CG  ? A ASP 64  CG  
18  1 Y 1 A ASP 64  ? OD1 ? A ASP 64  OD1 
19  1 Y 1 A ASP 64  ? OD2 ? A ASP 64  OD2 
20  1 Y 1 A LYS 68  ? CG  ? A LYS 68  CG  
21  1 Y 1 A LYS 68  ? CD  ? A LYS 68  CD  
22  1 Y 1 A LYS 68  ? CE  ? A LYS 68  CE  
23  1 Y 1 A LYS 68  ? NZ  ? A LYS 68  NZ  
24  1 Y 1 A ARG 69  ? CG  ? A ARG 69  CG  
25  1 Y 1 A ARG 69  ? CD  ? A ARG 69  CD  
26  1 Y 1 A ARG 69  ? NE  ? A ARG 69  NE  
27  1 Y 1 A ARG 69  ? CZ  ? A ARG 69  CZ  
28  1 Y 1 A ARG 69  ? NH1 ? A ARG 69  NH1 
29  1 Y 1 A ARG 69  ? NH2 ? A ARG 69  NH2 
30  1 Y 1 A ASN 76  ? CG  ? A ASN 76  CG  
31  1 Y 1 A ASN 76  ? OD1 ? A ASN 76  OD1 
32  1 Y 1 A ASN 76  ? ND2 ? A ASN 76  ND2 
33  1 Y 1 A LEU 78  ? CG  ? A LEU 78  CG  
34  1 Y 1 A LEU 78  ? CD1 ? A LEU 78  CD1 
35  1 Y 1 A LEU 78  ? CD2 ? A LEU 78  CD2 
36  1 Y 1 A ARG 86  ? CG  ? A ARG 86  CG  
37  1 Y 1 A ARG 86  ? CD  ? A ARG 86  CD  
38  1 Y 1 A ARG 86  ? NE  ? A ARG 86  NE  
39  1 Y 1 A ARG 86  ? CZ  ? A ARG 86  CZ  
40  1 Y 1 A ARG 86  ? NH1 ? A ARG 86  NH1 
41  1 Y 1 A ARG 86  ? NH2 ? A ARG 86  NH2 
42  1 Y 1 A GLU 94  ? CG  ? A GLU 94  CG  
43  1 Y 1 A GLU 94  ? CD  ? A GLU 94  CD  
44  1 Y 1 A GLU 94  ? OE1 ? A GLU 94  OE1 
45  1 Y 1 A GLU 94  ? OE2 ? A GLU 94  OE2 
46  1 Y 1 A GLN 124 ? CG  ? A GLN 124 CG  
47  1 Y 1 A GLN 124 ? CD  ? A GLN 124 CD  
48  1 Y 1 A GLN 124 ? OE1 ? A GLN 124 OE1 
49  1 Y 1 A GLN 124 ? NE2 ? A GLN 124 NE2 
50  1 Y 1 A LEU 126 ? CG  ? A LEU 126 CG  
51  1 Y 1 A LEU 126 ? CD1 ? A LEU 126 CD1 
52  1 Y 1 A LEU 126 ? CD2 ? A LEU 126 CD2 
53  1 Y 1 A ARG 130 ? CG  ? A ARG 130 CG  
54  1 Y 1 A ARG 130 ? CD  ? A ARG 130 CD  
55  1 Y 1 A ARG 130 ? NE  ? A ARG 130 NE  
56  1 Y 1 A ARG 130 ? CZ  ? A ARG 130 CZ  
57  1 Y 1 A ARG 130 ? NH1 ? A ARG 130 NH1 
58  1 Y 1 A ARG 130 ? NH2 ? A ARG 130 NH2 
59  1 Y 1 A LYS 131 ? CG  ? A LYS 131 CG  
60  1 Y 1 A LYS 131 ? CD  ? A LYS 131 CD  
61  1 Y 1 A LYS 131 ? CE  ? A LYS 131 CE  
62  1 Y 1 A LYS 131 ? NZ  ? A LYS 131 NZ  
63  1 Y 1 A GLU 138 ? CG  ? A GLU 138 CG  
64  1 Y 1 A GLU 138 ? CD  ? A GLU 138 CD  
65  1 Y 1 A GLU 138 ? OE1 ? A GLU 138 OE1 
66  1 Y 1 A GLU 138 ? OE2 ? A GLU 138 OE2 
67  1 Y 1 A GLU 169 ? CG  ? A GLU 169 CG  
68  1 Y 1 A GLU 169 ? CD  ? A GLU 169 CD  
69  1 Y 1 A GLU 169 ? OE1 ? A GLU 169 OE1 
70  1 Y 1 A GLU 169 ? OE2 ? A GLU 169 OE2 
71  1 Y 1 A GLN 199 ? CG  ? A GLN 199 CG  
72  1 Y 1 A GLN 199 ? CD  ? A GLN 199 CD  
73  1 Y 1 A GLN 199 ? OE1 ? A GLN 199 OE1 
74  1 Y 1 A GLN 199 ? NE2 ? A GLN 199 NE2 
75  1 Y 1 A VAL 229 ? CG1 ? A VAL 229 CG1 
76  1 Y 1 A VAL 229 ? CG2 ? A VAL 229 CG2 
77  1 Y 1 A PHE 244 ? CG  ? A PHE 244 CG  
78  1 Y 1 A PHE 244 ? CD1 ? A PHE 244 CD1 
79  1 Y 1 A PHE 244 ? CD2 ? A PHE 244 CD2 
80  1 Y 1 A PHE 244 ? CE1 ? A PHE 244 CE1 
81  1 Y 1 A PHE 244 ? CE2 ? A PHE 244 CE2 
82  1 Y 1 A PHE 244 ? CZ  ? A PHE 244 CZ  
83  1 Y 1 A ARG 325 ? CG  ? A ARG 325 CG  
84  1 Y 1 A ARG 325 ? CD  ? A ARG 325 CD  
85  1 Y 1 A ARG 325 ? NE  ? A ARG 325 NE  
86  1 Y 1 A ARG 325 ? CZ  ? A ARG 325 CZ  
87  1 Y 1 A ARG 325 ? NH1 ? A ARG 325 NH1 
88  1 Y 1 A ARG 325 ? NH2 ? A ARG 325 NH2 
89  1 Y 1 A ARG 328 ? CG  ? A ARG 328 CG  
90  1 Y 1 A ARG 328 ? CD  ? A ARG 328 CD  
91  1 Y 1 A ARG 328 ? NE  ? A ARG 328 NE  
92  1 Y 1 A ARG 328 ? CZ  ? A ARG 328 CZ  
93  1 Y 1 A ARG 328 ? NH1 ? A ARG 328 NH1 
94  1 Y 1 A ARG 328 ? NH2 ? A ARG 328 NH2 
95  1 Y 1 A ARG 378 ? CG  ? A ARG 378 CG  
96  1 Y 1 A ARG 378 ? CD  ? A ARG 378 CD  
97  1 Y 1 A ARG 378 ? NE  ? A ARG 378 NE  
98  1 Y 1 A ARG 378 ? CZ  ? A ARG 378 CZ  
99  1 Y 1 A ARG 378 ? NH1 ? A ARG 378 NH1 
100 1 Y 1 A ARG 378 ? NH2 ? A ARG 378 NH2 
101 1 Y 1 A ARG 381 ? CG  ? A ARG 381 CG  
102 1 Y 1 A ARG 381 ? CD  ? A ARG 381 CD  
103 1 Y 1 A ARG 381 ? NE  ? A ARG 381 NE  
104 1 Y 1 A ARG 381 ? CZ  ? A ARG 381 CZ  
105 1 Y 1 A ARG 381 ? NH1 ? A ARG 381 NH1 
106 1 Y 1 A ARG 381 ? NH2 ? A ARG 381 NH2 
107 1 Y 1 A ARG 390 ? CG  ? A ARG 390 CG  
108 1 Y 1 A ARG 390 ? CD  ? A ARG 390 CD  
109 1 Y 1 A ARG 390 ? NE  ? A ARG 390 NE  
110 1 Y 1 A ARG 390 ? CZ  ? A ARG 390 CZ  
111 1 Y 1 A ARG 390 ? NH1 ? A ARG 390 NH1 
112 1 Y 1 A ARG 390 ? NH2 ? A ARG 390 NH2 
113 1 Y 1 A VAL 422 ? CG1 ? A VAL 422 CG1 
114 1 Y 1 A VAL 422 ? CG2 ? A VAL 422 CG2 
115 1 Y 1 A LYS 423 ? CG  ? A LYS 423 CG  
116 1 Y 1 A LYS 423 ? CD  ? A LYS 423 CD  
117 1 Y 1 A LYS 423 ? CE  ? A LYS 423 CE  
118 1 Y 1 A LYS 423 ? NZ  ? A LYS 423 NZ  
119 1 Y 1 A ASN 439 ? CG  ? A ASN 439 CG  
120 1 Y 1 A ASN 439 ? OD1 ? A ASN 439 OD1 
121 1 Y 1 A ASN 439 ? ND2 ? A ASN 439 ND2 
122 1 Y 1 A GLU 445 ? CG  ? A GLU 445 CG  
123 1 Y 1 A GLU 445 ? CD  ? A GLU 445 CD  
124 1 Y 1 A GLU 445 ? OE1 ? A GLU 445 OE1 
125 1 Y 1 A GLU 445 ? OE2 ? A GLU 445 OE2 
126 1 Y 1 A SER 447 ? OG  ? A SER 447 OG  
127 1 Y 1 A LYS 461 ? CG  ? A LYS 461 CG  
128 1 Y 1 A LYS 461 ? CD  ? A LYS 461 CD  
129 1 Y 1 A LYS 461 ? CE  ? A LYS 461 CE  
130 1 Y 1 A LYS 461 ? NZ  ? A LYS 461 NZ  
131 1 Y 1 A ARG 471 ? CG  ? A ARG 471 CG  
132 1 Y 1 A ARG 471 ? CD  ? A ARG 471 CD  
133 1 Y 1 A ARG 471 ? NE  ? A ARG 471 NE  
134 1 Y 1 A ARG 471 ? CZ  ? A ARG 471 CZ  
135 1 Y 1 A ARG 471 ? NH1 ? A ARG 471 NH1 
136 1 Y 1 A ARG 471 ? NH2 ? A ARG 471 NH2 
137 1 Y 1 B ARG 15  ? CG  ? B ARG 15  CG  
138 1 Y 1 B ARG 15  ? CD  ? B ARG 15  CD  
139 1 Y 1 B ARG 15  ? NE  ? B ARG 15  NE  
140 1 Y 1 B ARG 15  ? CZ  ? B ARG 15  CZ  
141 1 Y 1 B ARG 15  ? NH1 ? B ARG 15  NH1 
142 1 Y 1 B ARG 15  ? NH2 ? B ARG 15  NH2 
143 1 Y 1 B ASN 35  ? CG  ? B ASN 35  CG  
144 1 Y 1 B ASN 35  ? OD1 ? B ASN 35  OD1 
145 1 Y 1 B ASN 35  ? ND2 ? B ASN 35  ND2 
146 1 Y 1 B LEU 50  ? CG  ? B LEU 50  CG  
147 1 Y 1 B LEU 50  ? CD1 ? B LEU 50  CD1 
148 1 Y 1 B LEU 50  ? CD2 ? B LEU 50  CD2 
149 1 Y 1 B GLU 54  ? CG  ? B GLU 54  CG  
150 1 Y 1 B GLU 54  ? CD  ? B GLU 54  CD  
151 1 Y 1 B GLU 54  ? OE1 ? B GLU 54  OE1 
152 1 Y 1 B GLU 54  ? OE2 ? B GLU 54  OE2 
153 1 Y 1 B LYS 68  ? CG  ? B LYS 68  CG  
154 1 Y 1 B LYS 68  ? CD  ? B LYS 68  CD  
155 1 Y 1 B LYS 68  ? CE  ? B LYS 68  CE  
156 1 Y 1 B LYS 68  ? NZ  ? B LYS 68  NZ  
157 1 Y 1 B ARG 69  ? CG  ? B ARG 69  CG  
158 1 Y 1 B ARG 69  ? CD  ? B ARG 69  CD  
159 1 Y 1 B ARG 69  ? NE  ? B ARG 69  NE  
160 1 Y 1 B ARG 69  ? CZ  ? B ARG 69  CZ  
161 1 Y 1 B ARG 69  ? NH1 ? B ARG 69  NH1 
162 1 Y 1 B ARG 69  ? NH2 ? B ARG 69  NH2 
163 1 Y 1 B THR 79  ? OG1 ? B THR 79  OG1 
164 1 Y 1 B THR 79  ? CG2 ? B THR 79  CG2 
165 1 Y 1 B ARG 86  ? CG  ? B ARG 86  CG  
166 1 Y 1 B ARG 86  ? CD  ? B ARG 86  CD  
167 1 Y 1 B ARG 86  ? NE  ? B ARG 86  NE  
168 1 Y 1 B ARG 86  ? CZ  ? B ARG 86  CZ  
169 1 Y 1 B ARG 86  ? NH1 ? B ARG 86  NH1 
170 1 Y 1 B ARG 86  ? NH2 ? B ARG 86  NH2 
171 1 Y 1 B GLU 94  ? CG  ? B GLU 94  CG  
172 1 Y 1 B GLU 94  ? CD  ? B GLU 94  CD  
173 1 Y 1 B GLU 94  ? OE1 ? B GLU 94  OE1 
174 1 Y 1 B GLU 94  ? OE2 ? B GLU 94  OE2 
175 1 Y 1 B ASP 120 ? CG  ? B ASP 120 CG  
176 1 Y 1 B ASP 120 ? OD1 ? B ASP 120 OD1 
177 1 Y 1 B ASP 120 ? OD2 ? B ASP 120 OD2 
178 1 Y 1 B ASP 122 ? CG  ? B ASP 122 CG  
179 1 Y 1 B ASP 122 ? OD1 ? B ASP 122 OD1 
180 1 Y 1 B ASP 122 ? OD2 ? B ASP 122 OD2 
181 1 Y 1 B GLN 124 ? CG  ? B GLN 124 CG  
182 1 Y 1 B GLN 124 ? CD  ? B GLN 124 CD  
183 1 Y 1 B GLN 124 ? OE1 ? B GLN 124 OE1 
184 1 Y 1 B GLN 124 ? NE2 ? B GLN 124 NE2 
185 1 Y 1 B LYS 131 ? CG  ? B LYS 131 CG  
186 1 Y 1 B LYS 131 ? CD  ? B LYS 131 CD  
187 1 Y 1 B LYS 131 ? CE  ? B LYS 131 CE  
188 1 Y 1 B LYS 131 ? NZ  ? B LYS 131 NZ  
189 1 Y 1 B GLU 143 ? CG  ? B GLU 143 CG  
190 1 Y 1 B GLU 143 ? CD  ? B GLU 143 CD  
191 1 Y 1 B GLU 143 ? OE1 ? B GLU 143 OE1 
192 1 Y 1 B GLU 143 ? OE2 ? B GLU 143 OE2 
193 1 Y 1 B GLU 169 ? CG  ? B GLU 169 CG  
194 1 Y 1 B GLU 169 ? CD  ? B GLU 169 CD  
195 1 Y 1 B GLU 169 ? OE1 ? B GLU 169 OE1 
196 1 Y 1 B GLU 169 ? OE2 ? B GLU 169 OE2 
197 1 Y 1 B ARG 253 ? CG  ? B ARG 253 CG  
198 1 Y 1 B ARG 253 ? CD  ? B ARG 253 CD  
199 1 Y 1 B ARG 253 ? NE  ? B ARG 253 NE  
200 1 Y 1 B ARG 253 ? CZ  ? B ARG 253 CZ  
201 1 Y 1 B ARG 253 ? NH1 ? B ARG 253 NH1 
202 1 Y 1 B ARG 253 ? NH2 ? B ARG 253 NH2 
203 1 Y 1 B ARG 328 ? CG  ? B ARG 328 CG  
204 1 Y 1 B ARG 328 ? CD  ? B ARG 328 CD  
205 1 Y 1 B ARG 328 ? NE  ? B ARG 328 NE  
206 1 Y 1 B ARG 328 ? CZ  ? B ARG 328 CZ  
207 1 Y 1 B ARG 328 ? NH1 ? B ARG 328 NH1 
208 1 Y 1 B ARG 328 ? NH2 ? B ARG 328 NH2 
209 1 Y 1 B ARG 381 ? CG  ? B ARG 381 CG  
210 1 Y 1 B ARG 381 ? CD  ? B ARG 381 CD  
211 1 Y 1 B ARG 381 ? NE  ? B ARG 381 NE  
212 1 Y 1 B ARG 381 ? CZ  ? B ARG 381 CZ  
213 1 Y 1 B ARG 381 ? NH1 ? B ARG 381 NH1 
214 1 Y 1 B ARG 381 ? NH2 ? B ARG 381 NH2 
215 1 Y 1 B GLU 388 ? CG  ? B GLU 388 CG  
216 1 Y 1 B GLU 388 ? CD  ? B GLU 388 CD  
217 1 Y 1 B GLU 388 ? OE1 ? B GLU 388 OE1 
218 1 Y 1 B GLU 388 ? OE2 ? B GLU 388 OE2 
219 1 Y 1 B ARG 390 ? CG  ? B ARG 390 CG  
220 1 Y 1 B ARG 390 ? CD  ? B ARG 390 CD  
221 1 Y 1 B ARG 390 ? NE  ? B ARG 390 NE  
222 1 Y 1 B ARG 390 ? CZ  ? B ARG 390 CZ  
223 1 Y 1 B ARG 390 ? NH1 ? B ARG 390 NH1 
224 1 Y 1 B ARG 390 ? NH2 ? B ARG 390 NH2 
225 1 Y 1 B ILE 406 ? CG1 ? B ILE 406 CG1 
226 1 Y 1 B ILE 406 ? CG2 ? B ILE 406 CG2 
227 1 Y 1 B ILE 406 ? CD1 ? B ILE 406 CD1 
228 1 Y 1 B LYS 423 ? CG  ? B LYS 423 CG  
229 1 Y 1 B LYS 423 ? CD  ? B LYS 423 CD  
230 1 Y 1 B LYS 423 ? CE  ? B LYS 423 CE  
231 1 Y 1 B LYS 423 ? NZ  ? B LYS 423 NZ  
232 1 Y 1 B GLU 445 ? CG  ? B GLU 445 CG  
233 1 Y 1 B GLU 445 ? CD  ? B GLU 445 CD  
234 1 Y 1 B GLU 445 ? OE1 ? B GLU 445 OE1 
235 1 Y 1 B GLU 445 ? OE2 ? B GLU 445 OE2 
236 1 Y 1 B LYS 446 ? CG  ? B LYS 446 CG  
237 1 Y 1 B LYS 446 ? CD  ? B LYS 446 CD  
238 1 Y 1 B LYS 446 ? CE  ? B LYS 446 CE  
239 1 Y 1 B LYS 446 ? NZ  ? B LYS 446 NZ  
240 1 Y 1 B SER 447 ? OG  ? B SER 447 OG  
241 1 Y 1 B GLU 449 ? CG  ? B GLU 449 CG  
242 1 Y 1 B GLU 449 ? CD  ? B GLU 449 CD  
243 1 Y 1 B GLU 449 ? OE1 ? B GLU 449 OE1 
244 1 Y 1 B GLU 449 ? OE2 ? B GLU 449 OE2 
245 1 Y 1 B ARG 460 ? CG  ? B ARG 460 CG  
246 1 Y 1 B ARG 460 ? CD  ? B ARG 460 CD  
247 1 Y 1 B ARG 460 ? NE  ? B ARG 460 NE  
248 1 Y 1 B ARG 460 ? CZ  ? B ARG 460 CZ  
249 1 Y 1 B ARG 460 ? NH1 ? B ARG 460 NH1 
250 1 Y 1 B ARG 460 ? NH2 ? B ARG 460 NH2 
251 1 Y 1 B LYS 461 ? CG  ? B LYS 461 CG  
252 1 Y 1 B LYS 461 ? CD  ? B LYS 461 CD  
253 1 Y 1 B LYS 461 ? CE  ? B LYS 461 CE  
254 1 Y 1 B LYS 461 ? NZ  ? B LYS 461 NZ  
255 1 Y 1 B GLU 468 ? CG  ? B GLU 468 CG  
256 1 Y 1 B GLU 468 ? CD  ? B GLU 468 CD  
257 1 Y 1 B GLU 468 ? OE1 ? B GLU 468 OE1 
258 1 Y 1 B GLU 468 ? OE2 ? B GLU 468 OE2 
259 1 Y 1 B GLU 479 ? CG  ? B GLU 479 CG  
260 1 Y 1 B GLU 479 ? CD  ? B GLU 479 CD  
261 1 Y 1 B GLU 479 ? OE1 ? B GLU 479 OE1 
262 1 Y 1 B GLU 479 ? OE2 ? B GLU 479 OE2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC ? ? ? 5.8.0267    1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? DIALS  ? ? ? .           2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? DIALS  ? ? ? .           3 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? PRIME  ? ? ? .           4 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .           5 
? 'model building' ? ? ? ? ? ? ? ? ? ? ? Coot   ? ? ? .           6 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.20.1-4487 7 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8RJS 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     184.098 
_cell.length_a_esd                 ? 
_cell.length_b                     184.098 
_cell.length_b_esd                 ? 
_cell.length_c                     180.962 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        24 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8RJS 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                182 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 63 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8RJS 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             3.90 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          68.50 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'BATCH MODE' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
'1.0 - 2.2 M ammonium sulphate, 2 - 12% PEG 1000, 0.1 M HEPES pH 6.8 - 7.7, 0.025% low-melt agarose' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            279 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     298 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     CCD 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         MPCCD 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2019-02-17 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.24028 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      'FREE ELECTRON LASER' 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SACLA BEAMLINE BL2' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.24028 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL2 
_diffrn_source.pdbx_synchrotron_site       SACLA 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8RJS 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.43 
_reflns.d_resolution_low                               92.22 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     68292 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                194.9 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          19.8 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.978 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.43 
_reflns_shell.d_res_low                                     2.49 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             4822 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.014 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            -0.35 
_refine.aniso_B[1][2]                            -0.17 
_refine.aniso_B[1][3]                            0.00 
_refine.aniso_B[2][2]                            -0.35 
_refine.aniso_B[2][3]                            0.00 
_refine.aniso_B[3][3]                            1.13 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               69.590 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.962 
_refine.correlation_coeff_Fo_to_Fc_free          0.944 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8RJS 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.43 
_refine.ls_d_res_low                             92.22 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     66289 
_refine.ls_number_reflns_R_free                  1999 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.99 
_refine.ls_percent_reflns_R_free                 2.9 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.21101 
_refine.ls_R_factor_R_free                       0.24804 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.20989 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.243 
_refine.pdbx_overall_ESU_R_Free                  0.209 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             11.880 
_refine.overall_SU_ML                            0.235 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.43 
_refine_hist.d_res_low                        92.22 
_refine_hist.number_atoms_solvent             88 
_refine_hist.number_atoms_total               7610 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        7410 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         112 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.003  0.013  7915  ? r_bond_refined_d             ? ? 
'X-RAY DIFFRACTION' ? 0.003  0.015  7264  ? r_bond_other_d               ? ? 
'X-RAY DIFFRACTION' ? 1.267  1.641  10825 ? r_angle_refined_deg          ? ? 
'X-RAY DIFFRACTION' ? 1.159  1.572  16630 ? r_angle_other_deg            ? ? 
'X-RAY DIFFRACTION' ? 5.701  5.000  1005  ? r_dihedral_angle_1_deg       ? ? 
'X-RAY DIFFRACTION' ? 28.588 19.599 424   ? r_dihedral_angle_2_deg       ? ? 
'X-RAY DIFFRACTION' ? 13.732 15.000 1176  ? r_dihedral_angle_3_deg       ? ? 
'X-RAY DIFFRACTION' ? 13.082 15.000 59    ? r_dihedral_angle_4_deg       ? ? 
'X-RAY DIFFRACTION' ? 0.041  0.200  1038  ? r_chiral_restr               ? ? 
'X-RAY DIFFRACTION' ? 0.006  0.020  9999  ? r_gen_planes_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.013  0.020  1855  ? r_gen_planes_other           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbd_refined                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbd_other                  ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbtor_refined              ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbtor_other                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_xyhbond_nbd_refined        ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_xyhbond_nbd_other          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_metal_ion_refined          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_metal_ion_other            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_vdw_refined       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_vdw_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_hbond_refined     ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_hbond_other       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_metal_ion_refined ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_metal_ion_other   ? ? 
'X-RAY DIFFRACTION' ? 2.502  7.533  3948  ? r_mcbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 2.502  7.532  3947  ? r_mcbond_other               ? ? 
'X-RAY DIFFRACTION' ? 4.146  11.289 4935  ? r_mcangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 4.146  11.291 4936  ? r_mcangle_other              ? ? 
'X-RAY DIFFRACTION' ? 2.553  7.751  3967  ? r_scbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 2.549  7.722  3948  ? r_scbond_other               ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_scangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 4.361  11.501 5845  ? r_scangle_other              ? ? 
'X-RAY DIFFRACTION' ? 7.319  85.146 8445  ? r_long_range_B_refined       ? ? 
'X-RAY DIFFRACTION' ? 7.319  85.136 8441  ? r_long_range_B_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_rigid_bond_restr           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_sphericity_free            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_sphericity_bonded          ? ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       2.430 
_refine_ls_shell.d_res_low                        2.493 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             145 
_refine_ls_shell.number_reflns_R_work             4822 
_refine_ls_shell.percent_reflns_obs               100.00 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.R_factor_R_work                  0.460 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
_refine_ls_shell.R_factor_R_free                  0.444 
# 
_struct.entry_id                     8RJS 
_struct.title                        
;Serial femtosecond X-ray structure of a fluorescence optimized bathy phytochrome PAiRFP2 derived from wild-type Agp2 in I5 intermediate state.
;
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8RJS 
_struct_keywords.text            
'fluorescent protein, phytochrome, bacteriophytochrome, intermediate, optogenetic, SIGNALING PROTEIN' 
_struct_keywords.pdbx_keywords   'SIGNALING PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 3 ? 
F N N 2 ? 
G N N 3 ? 
H N N 3 ? 
I N N 3 ? 
J N N 4 ? 
K N N 5 ? 
L N N 5 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    A9CI81_AGRFC 
_struct_ref.pdbx_db_accession          A9CI81 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MASTDYHVDLTNCDREPIHIPGYIQPHGCLIACDNAMRMVLRHSENCGELLGLEGDLNGRTAEDVLGKKLVHDLRNALTV
TGRTTRPAMLPAMETSDGRSFDISLHRYKSTTIIEFEPSGSDAQPLGTARKMVDRIREADSVESLISRTTRLVKATLGYD
RVMIYRFQEDGAGKVVSEAKQPELESFLGQYFPASDIPQQARALYLKNTLRIISDASGTRIPVLPAVDVSGEPLDLSYAH
LRSVSPIHCEYLRNMGVAASMSISVIVDGALWGLIACHHYSPRVLSMPVRIAAEMFGEFFSMHLQVLKQKRRLDTINHAH
AALDRFLRLAAHHANIEELLVDSFQDFADLMPCDGVGLWVGNNWHGHGATPPHDAIPRLARFVASASEGRVWATHALSQA
IPEAEIYAGTAAGMLAIPLSQVKSDYLLFFRKEIVQNLNWAGNPEKSYETGPMGDRLTPRKSFAIWKETVRLQAQPWSEA
DREIAEAARIALVEVAFHHSEL
;
_struct_ref.pdbx_align_begin           1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8RJS A 1 ? 502 ? A9CI81 1 ? 502 ? 1 502 
2 1 8RJS B 1 ? 502 ? A9CI81 1 ? 502 ? 1 502 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8RJS ARG A 69  ? UNP A9CI81 LYS 69  'engineered mutation' 69  1  
1 8RJS LYS A 83  ? UNP A9CI81 ARG 83  'engineered mutation' 83  2  
1 8RJS ASP A 120 ? UNP A9CI81 GLY 120 'engineered mutation' 120 3  
1 8RJS THR A 123 ? UNP A9CI81 ALA 123 'engineered mutation' 123 4  
1 8RJS LEU A 163 ? UNP A9CI81 MET 163 'engineered mutation' 163 5  
1 8RJS GLU A 168 ? UNP A9CI81 GLN 168 'engineered mutation' 168 6  
1 8RJS PRO A 220 ? UNP A9CI81 ARG 220 'engineered mutation' 220 7  
1 8RJS ASN A 243 ? UNP A9CI81 SER 243 'engineered mutation' 243 8  
1 8RJS PHE A 244 ? UNP A9CI81 VAL 244 'engineered mutation' 244 9  
1 8RJS ASP A 269 ? UNP A9CI81 GLY 269 'engineered mutation' 269 10 
1 8RJS VAL A 276 ? UNP A9CI81 ALA 276 'engineered mutation' 276 11 
1 8RJS CYS A 280 ? UNP A9CI81 TYR 280 'engineered mutation' 280 12 
1 8RJS ALA A 294 ? UNP A9CI81 GLU 294 'engineered mutation' 294 13 
1 8RJS PHE A 303 ? UNP A9CI81 HIS 303 'engineered mutation' 303 14 
1 8RJS ARG A 333 ? UNP A9CI81 HIS 333 'engineered mutation' 333 15 
1 8RJS LEU A 336 ? UNP A9CI81 ILE 336 'engineered mutation' 336 16 
1 8RJS ARG A 349 ? UNP A9CI81 ASP 349 'engineered mutation' 349 17 
1 8RJS ILE A 351 ? UNP A9CI81 MET 351 'engineered mutation' 351 18 
1 8RJS VAL A 386 ? UNP A9CI81 ALA 386 'engineered mutation' 386 19 
1 8RJS ASP A 409 ? UNP A9CI81 GLY 409 'engineered mutation' 409 20 
1 8RJS ILE A 419 ? UNP A9CI81 LEU 419 'engineered mutation' 419 21 
1 8RJS SER A 469 ? UNP A9CI81 THR 469 'engineered mutation' 469 22 
1 8RJS THR A 487 ? UNP A9CI81 ALA 487 'engineered mutation' 487 23 
1 8RJS GLY A 494 ? UNP A9CI81 GLU 494 'engineered mutation' 494 24 
1 8RJS MET A 503 ? UNP A9CI81 ?   ?   insertion             503 25 
1 8RJS ALA A 504 ? UNP A9CI81 ?   ?   insertion             504 26 
1 8RJS GLY A 505 ? UNP A9CI81 ?   ?   insertion             505 27 
1 8RJS LEU A 506 ? UNP A9CI81 ?   ?   insertion             506 28 
1 8RJS GLU A 507 ? UNP A9CI81 ?   ?   insertion             507 29 
1 8RJS TYR A 508 ? UNP A9CI81 ?   ?   insertion             508 30 
1 8RJS LYS A 509 ? UNP A9CI81 ?   ?   insertion             509 31 
1 8RJS HIS A 510 ? UNP A9CI81 ?   ?   'expression tag'      510 32 
1 8RJS HIS A 511 ? UNP A9CI81 ?   ?   'expression tag'      511 33 
1 8RJS HIS A 512 ? UNP A9CI81 ?   ?   'expression tag'      512 34 
1 8RJS HIS A 513 ? UNP A9CI81 ?   ?   'expression tag'      513 35 
1 8RJS HIS A 514 ? UNP A9CI81 ?   ?   'expression tag'      514 36 
1 8RJS HIS A 515 ? UNP A9CI81 ?   ?   'expression tag'      515 37 
2 8RJS ARG B 69  ? UNP A9CI81 LYS 69  'engineered mutation' 69  38 
2 8RJS LYS B 83  ? UNP A9CI81 ARG 83  'engineered mutation' 83  39 
2 8RJS ASP B 120 ? UNP A9CI81 GLY 120 'engineered mutation' 120 40 
2 8RJS THR B 123 ? UNP A9CI81 ALA 123 'engineered mutation' 123 41 
2 8RJS LEU B 163 ? UNP A9CI81 MET 163 'engineered mutation' 163 42 
2 8RJS GLU B 168 ? UNP A9CI81 GLN 168 'engineered mutation' 168 43 
2 8RJS PRO B 220 ? UNP A9CI81 ARG 220 'engineered mutation' 220 44 
2 8RJS ASN B 243 ? UNP A9CI81 SER 243 'engineered mutation' 243 45 
2 8RJS PHE B 244 ? UNP A9CI81 VAL 244 'engineered mutation' 244 46 
2 8RJS ASP B 269 ? UNP A9CI81 GLY 269 'engineered mutation' 269 47 
2 8RJS VAL B 276 ? UNP A9CI81 ALA 276 'engineered mutation' 276 48 
2 8RJS CYS B 280 ? UNP A9CI81 TYR 280 'engineered mutation' 280 49 
2 8RJS ALA B 294 ? UNP A9CI81 GLU 294 'engineered mutation' 294 50 
2 8RJS PHE B 303 ? UNP A9CI81 HIS 303 'engineered mutation' 303 51 
2 8RJS ARG B 333 ? UNP A9CI81 HIS 333 'engineered mutation' 333 52 
2 8RJS LEU B 336 ? UNP A9CI81 ILE 336 'engineered mutation' 336 53 
2 8RJS ARG B 349 ? UNP A9CI81 ASP 349 'engineered mutation' 349 54 
2 8RJS ILE B 351 ? UNP A9CI81 MET 351 'engineered mutation' 351 55 
2 8RJS VAL B 386 ? UNP A9CI81 ALA 386 'engineered mutation' 386 56 
2 8RJS ASP B 409 ? UNP A9CI81 GLY 409 'engineered mutation' 409 57 
2 8RJS ILE B 419 ? UNP A9CI81 LEU 419 'engineered mutation' 419 58 
2 8RJS SER B 469 ? UNP A9CI81 THR 469 'engineered mutation' 469 59 
2 8RJS THR B 487 ? UNP A9CI81 ALA 487 'engineered mutation' 487 60 
2 8RJS GLY B 494 ? UNP A9CI81 GLU 494 'engineered mutation' 494 61 
2 8RJS MET B 503 ? UNP A9CI81 ?   ?   insertion             503 62 
2 8RJS ALA B 504 ? UNP A9CI81 ?   ?   insertion             504 63 
2 8RJS GLY B 505 ? UNP A9CI81 ?   ?   insertion             505 64 
2 8RJS LEU B 506 ? UNP A9CI81 ?   ?   insertion             506 65 
2 8RJS GLU B 507 ? UNP A9CI81 ?   ?   insertion             507 66 
2 8RJS TYR B 508 ? UNP A9CI81 ?   ?   insertion             508 67 
2 8RJS LYS B 509 ? UNP A9CI81 ?   ?   insertion             509 68 
2 8RJS HIS B 510 ? UNP A9CI81 ?   ?   'expression tag'      510 69 
2 8RJS HIS B 511 ? UNP A9CI81 ?   ?   'expression tag'      511 70 
2 8RJS HIS B 512 ? UNP A9CI81 ?   ?   'expression tag'      512 71 
2 8RJS HIS B 513 ? UNP A9CI81 ?   ?   'expression tag'      513 72 
2 8RJS HIS B 514 ? UNP A9CI81 ?   ?   'expression tag'      514 73 
2 8RJS HIS B 515 ? UNP A9CI81 ?   ?   'expression tag'      515 74 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_and_software_defined_assembly PISA dimeric 2 
2 author_and_software_defined_assembly PISA dimeric 2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 6080  ? 
1 MORE         -97   ? 
1 'SSA (A^2)'  40560 ? 
2 'ABSA (A^2)' 6980  ? 
2 MORE         -135  ? 
2 'SSA (A^2)'  41090 ? 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1,2 A,C,D,E,K     
2 1,3 B,F,G,H,I,J,L 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555  x,y,z        1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000   
2 'crystal symmetry operation' 8_555  x-y,-y,-z    1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 0.0000000000   
3 'crystal symmetry operation' 12_554 x,x-y,-z-1/2 0.5000000000 0.8660254038 0.0000000000 0.0000000000 0.8660254038 -0.5000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 -90.4810000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASN A 46  ? GLY A 52  ? ASN A 46  GLY A 52  1 ? 7  
HELX_P HELX_P2  AA2 THR A 61  ? LEU A 66  ? THR A 61  LEU A 66  1 ? 6  
HELX_P HELX_P3  AA3 GLY A 67  ? LEU A 78  ? GLY A 67  LEU A 78  1 ? 12 
HELX_P HELX_P4  AA4 GLN A 124 ? ARG A 135 ? GLN A 124 ARG A 135 1 ? 12 
HELX_P HELX_P5  AA5 SER A 141 ? GLY A 158 ? SER A 141 GLY A 158 1 ? 18 
HELX_P HELX_P6  AA6 PRO A 193 ? ILE A 197 ? PRO A 193 ILE A 197 5 ? 5  
HELX_P HELX_P7  AA7 PRO A 198 ? ASN A 208 ? PRO A 198 ASN A 208 1 ? 11 
HELX_P HELX_P8  AA8 SER A 245 ? MET A 255 ? SER A 245 MET A 255 1 ? 11 
HELX_P HELX_P9  AA9 SER A 286 ? ARG A 333 ? SER A 286 ARG A 333 1 ? 48 
HELX_P HELX_P10 AB1 ASN A 335 ? PHE A 344 ? ASN A 335 PHE A 344 1 ? 10 
HELX_P HELX_P11 AB2 GLN A 345 ? LEU A 350 ? GLN A 345 LEU A 350 5 ? 6  
HELX_P HELX_P12 AB3 PRO A 372 ? ASP A 374 ? PRO A 372 ASP A 374 5 ? 3  
HELX_P HELX_P13 AB4 ALA A 375 ? GLU A 388 ? ALA A 375 GLU A 388 1 ? 14 
HELX_P HELX_P14 AB5 ILE A 401 ? ALA A 408 ? ILE A 401 ALA A 408 5 ? 8  
HELX_P HELX_P15 AB6 GLU A 433 ? LEU A 438 ? GLU A 433 LEU A 438 5 ? 6  
HELX_P HELX_P16 AB7 GLY A 454 ? LEU A 457 ? GLY A 454 LEU A 457 5 ? 4  
HELX_P HELX_P17 AB8 THR A 458 ? VAL A 470 ? THR A 458 VAL A 470 1 ? 13 
HELX_P HELX_P18 AB9 SER A 478 ? HIS A 499 ? SER A 478 HIS A 499 1 ? 22 
HELX_P HELX_P19 AC1 ASN B 12  ? GLU B 16  ? ASN B 12  GLU B 16  5 ? 5  
HELX_P HELX_P20 AC2 ASN B 46  ? GLY B 52  ? ASN B 46  GLY B 52  1 ? 7  
HELX_P HELX_P21 AC3 THR B 61  ? GLY B 67  ? THR B 61  GLY B 67  1 ? 7  
HELX_P HELX_P22 AC4 GLY B 67  ? THR B 79  ? GLY B 67  THR B 79  1 ? 13 
HELX_P HELX_P23 AC5 GLN B 124 ? ARG B 135 ? GLN B 124 ARG B 135 1 ? 12 
HELX_P HELX_P24 AC6 SER B 141 ? LEU B 157 ? SER B 141 LEU B 157 1 ? 17 
HELX_P HELX_P25 AC7 PRO B 193 ? ILE B 197 ? PRO B 193 ILE B 197 5 ? 5  
HELX_P HELX_P26 AC8 PRO B 198 ? ASN B 208 ? PRO B 198 ASN B 208 1 ? 11 
HELX_P HELX_P27 AC9 SER B 245 ? MET B 255 ? SER B 245 MET B 255 1 ? 11 
HELX_P HELX_P28 AD1 SER B 286 ? ARG B 333 ? SER B 286 ARG B 333 1 ? 48 
HELX_P HELX_P29 AD2 ASN B 335 ? PHE B 344 ? ASN B 335 PHE B 344 1 ? 10 
HELX_P HELX_P30 AD3 GLN B 345 ? LEU B 350 ? GLN B 345 LEU B 350 5 ? 6  
HELX_P HELX_P31 AD4 PRO B 372 ? ASP B 374 ? PRO B 372 ASP B 374 5 ? 3  
HELX_P HELX_P32 AD5 ALA B 375 ? SER B 387 ? ALA B 375 SER B 387 1 ? 13 
HELX_P HELX_P33 AD6 ALA B 396 ? ILE B 401 ? ALA B 396 ILE B 401 1 ? 6  
HELX_P HELX_P34 AD7 PRO B 402 ? ALA B 408 ? PRO B 402 ALA B 408 5 ? 7  
HELX_P HELX_P35 AD8 GLU B 433 ? LEU B 438 ? GLU B 433 LEU B 438 5 ? 6  
HELX_P HELX_P36 AD9 THR B 458 ? VAL B 470 ? THR B 458 VAL B 470 1 ? 13 
HELX_P HELX_P37 AE1 SER B 478 ? HIS B 499 ? SER B 478 HIS B 499 1 ? 22 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
covale1 covale none ? A CYS 13 SG ? ? ? 1_555 C EL5 . CBA A ? A CYS 13 A EL5 601 1_555 ? ? ? ? ? ? ? 1.635 ? ? 
covale2 covale none ? A CYS 13 SG ? ? ? 1_555 C EL5 . CBA B ? A CYS 13 A EL5 601 1_555 ? ? ? ? ? ? ? 1.632 ? ? 
covale3 covale none ? B CYS 13 SG ? ? ? 1_555 F EL5 . CBA A ? B CYS 13 B EL5 601 1_555 ? ? ? ? ? ? ? 1.623 ? ? 
covale4 covale none ? B CYS 13 SG ? ? ? 1_555 F EL5 . CBA B ? B CYS 13 B EL5 601 1_555 ? ? ? ? ? ? ? 1.649 ? ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 EL5 C . A CYS A 13 ? EL5 A 601 ? 1_555 CYS A 13 ? 1_555 CBA SG CYS 1 EL5 None 'Covalent chemical modification' 
2 EL5 C . B CYS A 13 ? EL5 A 601 ? 1_555 CYS A 13 ? 1_555 CBA SG CYS 1 EL5 None 'Covalent chemical modification' 
3 EL5 F . A CYS B 13 ? EL5 B 601 ? 1_555 CYS B 13 ? 1_555 CBA SG CYS 1 EL5 None 'Covalent chemical modification' 
4 EL5 F . B CYS B 13 ? EL5 B 601 ? 1_555 CYS B 13 ? 1_555 CBA SG CYS 1 EL5 None 'Covalent chemical modification' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 LEU 224 A . ? LEU 224 A PRO 225 A ? PRO 225 A 1 -12.95 
2 LEU 224 B . ? LEU 224 B PRO 225 B ? PRO 225 B 1 -4.13  
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 6 ? 
AA3 ? 5 ? 
AA4 ? 7 ? 
AA5 ? 6 ? 
AA6 ? 5 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA2 5 6 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA3 4 5 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA4 4 5 ? anti-parallel 
AA4 5 6 ? anti-parallel 
AA4 6 7 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA5 4 5 ? anti-parallel 
AA5 5 6 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA6 4 5 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 TYR A 23  ? ILE A 24  ? TYR A 23  ILE A 24  
AA1 2 ILE A 221 ? LEU A 224 ? ILE A 221 LEU A 224 
AA1 3 VAL A 40  ? SER A 44  ? VAL A 40  SER A 44  
AA1 4 CYS A 29  ? ASP A 34  ? CYS A 29  ASP A 34  
AA1 5 THR A 111 ? PRO A 118 ? THR A 111 PRO A 118 
AA1 6 SER A 100 ? ARG A 107 ? SER A 100 ARG A 107 
AA1 7 ALA A 88  ? GLU A 94  ? ALA A 88  GLU A 94  
AA2 1 TYR A 191 ? PHE A 192 ? TYR A 191 PHE A 192 
AA2 2 GLY A 173 ? LYS A 180 ? GLY A 173 LYS A 180 
AA2 3 ARG A 161 ? PHE A 167 ? ARG A 161 PHE A 167 
AA2 4 ALA A 270 ? HIS A 279 ? ALA A 270 HIS A 279 
AA2 5 ALA A 259 ? VAL A 267 ? ALA A 259 VAL A 267 
AA2 6 LEU A 210 ? ILE A 213 ? LEU A 210 ILE A 213 
AA3 1 ASN A 363 ? GLY A 368 ? ASN A 363 GLY A 368 
AA3 2 GLY A 355 ? VAL A 360 ? GLY A 355 VAL A 360 
AA3 3 TYR A 426 ? ARG A 431 ? TYR A 426 ARG A 431 
AA3 4 GLY A 413 ? PRO A 418 ? GLY A 413 PRO A 418 
AA3 5 TRP A 392 ? THR A 394 ? TRP A 392 THR A 394 
AA4 1 TYR B 23  ? ILE B 24  ? TYR B 23  ILE B 24  
AA4 2 ILE B 221 ? LEU B 224 ? ILE B 221 LEU B 224 
AA4 3 VAL B 40  ? SER B 44  ? VAL B 40  SER B 44  
AA4 4 CYS B 29  ? ASP B 34  ? CYS B 29  ASP B 34  
AA4 5 THR B 111 ? PRO B 118 ? THR B 111 PRO B 118 
AA4 6 SER B 100 ? TYR B 108 ? SER B 100 TYR B 108 
AA4 7 ALA B 88  ? GLU B 94  ? ALA B 88  GLU B 94  
AA5 1 TYR B 191 ? PHE B 192 ? TYR B 191 PHE B 192 
AA5 2 GLY B 173 ? LYS B 180 ? GLY B 173 LYS B 180 
AA5 3 ARG B 161 ? PHE B 167 ? ARG B 161 PHE B 167 
AA5 4 ALA B 270 ? HIS B 279 ? ALA B 270 HIS B 279 
AA5 5 ALA B 259 ? VAL B 267 ? ALA B 259 VAL B 267 
AA5 6 LEU B 210 ? ILE B 213 ? LEU B 210 ILE B 213 
AA6 1 ASN B 363 ? GLY B 368 ? ASN B 363 GLY B 368 
AA6 2 GLY B 355 ? VAL B 360 ? GLY B 355 VAL B 360 
AA6 3 TYR B 426 ? ARG B 431 ? TYR B 426 ARG B 431 
AA6 4 GLY B 413 ? PRO B 418 ? GLY B 413 PRO B 418 
AA6 5 TRP B 392 ? THR B 394 ? TRP B 392 THR B 394 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ILE A 24  ? N ILE A 24  O ILE A 221 ? O ILE A 221 
AA1 2 3 O LEU A 224 ? O LEU A 224 N HIS A 43  ? N HIS A 43  
AA1 3 4 O SER A 44  ? O SER A 44  N LEU A 30  ? N LEU A 30  
AA1 4 5 N CYS A 33  ? N CYS A 33  O THR A 112 ? O THR A 112 
AA1 5 6 O ILE A 113 ? O ILE A 113 N HIS A 106 ? N HIS A 106 
AA1 6 7 O PHE A 101 ? O PHE A 101 N MET A 93  ? N MET A 93  
AA2 1 2 O PHE A 192 ? O PHE A 192 N GLY A 173 ? N GLY A 173 
AA2 2 3 O LYS A 174 ? O LYS A 174 N ARG A 166 ? N ARG A 166 
AA2 3 4 N TYR A 165 ? N TYR A 165 O LEU A 274 ? O LEU A 274 
AA2 4 5 O CYS A 277 ? O CYS A 277 N MET A 261 ? N MET A 261 
AA2 5 6 O SER A 260 ? O SER A 260 N ILE A 213 ? N ILE A 213 
AA3 1 2 O HIS A 365 ? O HIS A 365 N LEU A 358 ? N LEU A 358 
AA3 2 3 N GLY A 355 ? N GLY A 355 O PHE A 430 ? O PHE A 430 
AA3 3 4 O PHE A 429 ? O PHE A 429 N LEU A 415 ? N LEU A 415 
AA3 4 5 O ALA A 416 ? O ALA A 416 N TRP A 392 ? N TRP A 392 
AA4 1 2 N ILE B 24  ? N ILE B 24  O ILE B 221 ? O ILE B 221 
AA4 2 3 O LEU B 224 ? O LEU B 224 N HIS B 43  ? N HIS B 43  
AA4 3 4 O ARG B 42  ? O ARG B 42  N ALA B 32  ? N ALA B 32  
AA4 4 5 N CYS B 33  ? N CYS B 33  O THR B 112 ? O THR B 112 
AA4 5 6 O ILE B 113 ? O ILE B 113 N HIS B 106 ? N HIS B 106 
AA4 6 7 O LEU B 105 ? O LEU B 105 N ALA B 88  ? N ALA B 88  
AA5 1 2 O PHE B 192 ? O PHE B 192 N GLY B 173 ? N GLY B 173 
AA5 2 3 O LYS B 174 ? O LYS B 174 N ARG B 166 ? N ARG B 166 
AA5 3 4 N LEU B 163 ? N LEU B 163 O VAL B 276 ? O VAL B 276 
AA5 4 5 O CYS B 277 ? O CYS B 277 N MET B 261 ? N MET B 261 
AA5 5 6 O SER B 260 ? O SER B 260 N ILE B 213 ? N ILE B 213 
AA6 1 2 O HIS B 367 ? O HIS B 367 N VAL B 356 ? N VAL B 356 
AA6 2 3 N GLY B 357 ? N GLY B 357 O LEU B 428 ? O LEU B 428 
AA6 3 4 O PHE B 429 ? O PHE B 429 N LEU B 415 ? N LEU B 415 
AA6 4 5 O ALA B 416 ? O ALA B 416 N TRP B 392 ? N TRP B 392 
# 
_pdbx_entry_details.entry_id                   8RJS 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 LEU A 236 ? ? -99.50  30.48   
2  1 ARG A 283 ? ? -160.19 119.80  
3  1 SER A 424 ? ? -96.67  59.96   
4  1 ASN A 439 ? ? -101.80 58.48   
5  1 HIS A 499 ? ? -99.68  38.05   
6  1 THR B 79  ? ? -66.67  70.68   
7  1 THR B 95  ? ? -86.83  -145.73 
8  1 ASP B 122 ? ? -143.33 33.39   
9  1 VAL B 422 ? ? -102.54 -78.75  
10 1 ASN B 439 ? ? -113.71 66.37   
# 
loop_
_pdbx_validate_chiral.id 
_pdbx_validate_chiral.PDB_model_num 
_pdbx_validate_chiral.auth_atom_id 
_pdbx_validate_chiral.label_alt_id 
_pdbx_validate_chiral.auth_asym_id 
_pdbx_validate_chiral.auth_comp_id 
_pdbx_validate_chiral.auth_seq_id 
_pdbx_validate_chiral.PDB_ins_code 
_pdbx_validate_chiral.details 
_pdbx_validate_chiral.omega 
1 1 C2A A A EL5 601 ? PLANAR . 
2 1 C2A B A EL5 601 ? PLANAR . 
3 1 C2A A B EL5 601 ? PLANAR . 
4 1 C2A B B EL5 601 ? PLANAR . 
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A SO4 602 ? D SO4 . 
2 1 A SO4 602 ? D SO4 . 
3 1 B SO4 603 ? H SO4 . 
4 1 B SO4 603 ? H SO4 . 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 753 ? 6.18 . 
2 1 O ? B HOH 734 ? 6.12 . 
3 1 O ? B HOH 735 ? 7.19 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 1   ? A MET 1   
2  1 Y 1 A ALA 2   ? A ALA 2   
3  1 Y 1 A SER 3   ? A SER 3   
4  1 Y 1 A THR 4   ? A THR 4   
5  1 Y 1 A ASP 5   ? A ASP 5   
6  1 Y 1 A TYR 6   ? A TYR 6   
7  1 Y 1 A HIS 7   ? A HIS 7   
8  1 Y 1 A VAL 80  ? A VAL 80  
9  1 Y 1 A THR 81  ? A THR 81  
10 1 Y 1 A GLY 82  ? A GLY 82  
11 1 Y 1 A LYS 83  ? A LYS 83  
12 1 Y 1 A ASP 120 ? A ASP 120 
13 1 Y 1 A GLU 501 ? A GLU 501 
14 1 Y 1 A LEU 502 ? A LEU 502 
15 1 Y 1 A MET 503 ? A MET 503 
16 1 Y 1 A ALA 504 ? A ALA 504 
17 1 Y 1 A GLY 505 ? A GLY 505 
18 1 Y 1 A LEU 506 ? A LEU 506 
19 1 Y 1 A GLU 507 ? A GLU 507 
20 1 Y 1 A TYR 508 ? A TYR 508 
21 1 Y 1 A LYS 509 ? A LYS 509 
22 1 Y 1 A HIS 510 ? A HIS 510 
23 1 Y 1 A HIS 511 ? A HIS 511 
24 1 Y 1 A HIS 512 ? A HIS 512 
25 1 Y 1 A HIS 513 ? A HIS 513 
26 1 Y 1 A HIS 514 ? A HIS 514 
27 1 Y 1 A HIS 515 ? A HIS 515 
28 1 Y 1 B MET 1   ? B MET 1   
29 1 Y 1 B ALA 2   ? B ALA 2   
30 1 Y 1 B SER 3   ? B SER 3   
31 1 Y 1 B THR 4   ? B THR 4   
32 1 Y 1 B THR 81  ? B THR 81  
33 1 Y 1 B GLY 82  ? B GLY 82  
34 1 Y 1 B LYS 83  ? B LYS 83  
35 1 Y 1 B THR 84  ? B THR 84  
36 1 Y 1 B GLU 501 ? B GLU 501 
37 1 Y 1 B LEU 502 ? B LEU 502 
38 1 Y 1 B MET 503 ? B MET 503 
39 1 Y 1 B ALA 504 ? B ALA 504 
40 1 Y 1 B GLY 505 ? B GLY 505 
41 1 Y 1 B LEU 506 ? B LEU 506 
42 1 Y 1 B GLU 507 ? B GLU 507 
43 1 Y 1 B TYR 508 ? B TYR 508 
44 1 Y 1 B LYS 509 ? B LYS 509 
45 1 Y 1 B HIS 510 ? B HIS 510 
46 1 Y 1 B HIS 511 ? B HIS 511 
47 1 Y 1 B HIS 512 ? B HIS 512 
48 1 Y 1 B HIS 513 ? B HIS 513 
49 1 Y 1 B HIS 514 ? B HIS 514 
50 1 Y 1 B HIS 515 ? B HIS 515 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CL  CL   CL N N 74  
CYS N    N  N N 75  
CYS CA   C  N R 76  
CYS C    C  N N 77  
CYS O    O  N N 78  
CYS CB   C  N N 79  
CYS SG   S  N N 80  
CYS OXT  O  N N 81  
CYS H    H  N N 82  
CYS H2   H  N N 83  
CYS HA   H  N N 84  
CYS HB2  H  N N 85  
CYS HB3  H  N N 86  
CYS HG   H  N N 87  
CYS HXT  H  N N 88  
EL5 C1A  C  N N 89  
EL5 C1B  C  N N 90  
EL5 O1B  O  N N 91  
EL5 C1C  C  Y N 92  
EL5 O1C  O  N N 93  
EL5 C1D  C  N N 94  
EL5 C2A  C  N S 95  
EL5 C2B  C  N N 96  
EL5 O2B  O  N N 97  
EL5 C2C  C  Y N 98  
EL5 O2C  O  N N 99  
EL5 C2D  C  N N 100 
EL5 C3A  C  N N 101 
EL5 C3B  C  N N 102 
EL5 C3C  C  Y N 103 
EL5 C3D  C  N N 104 
EL5 C4A  C  N N 105 
EL5 C4B  C  N N 106 
EL5 C4C  C  Y N 107 
EL5 C4D  C  N N 108 
EL5 CAA  C  N N 109 
EL5 CAB  C  N N 110 
EL5 CAC  C  N N 111 
EL5 CAD  C  N N 112 
EL5 CBA  C  N N 113 
EL5 CBB  C  N N 114 
EL5 CBC  C  N N 115 
EL5 CBD  C  N N 116 
EL5 CGB  C  N N 117 
EL5 CGC  C  N N 118 
EL5 CHB  C  N N 119 
EL5 CHC  C  N N 120 
EL5 CHD  C  N N 121 
EL5 CMA  C  N N 122 
EL5 CMB  C  N N 123 
EL5 CMC  C  N N 124 
EL5 CMD  C  N N 125 
EL5 NA   N  N N 126 
EL5 OA   O  N N 127 
EL5 NB   N  N N 128 
EL5 NC   N  Y N 129 
EL5 ND   N  N N 130 
EL5 OD   O  N N 131 
EL5 H1   H  N N 132 
EL5 H2   H  N N 133 
EL5 H3   H  N N 134 
EL5 H4   H  N N 135 
EL5 H6   H  N N 136 
EL5 H7   H  N N 137 
EL5 H8   H  N N 138 
EL5 H9   H  N N 139 
EL5 H10  H  N N 140 
EL5 H12  H  N N 141 
EL5 H13  H  N N 142 
EL5 H14  H  N N 143 
EL5 H15  H  N N 144 
EL5 H16  H  N N 145 
EL5 H17  H  N N 146 
EL5 H18  H  N N 147 
EL5 H19  H  N N 148 
EL5 H20  H  N N 149 
EL5 H22  H  N N 150 
EL5 H24  H  N N 151 
EL5 H26  H  N N 152 
EL5 H28  H  N N 153 
EL5 H29  H  N N 154 
EL5 H30  H  N N 155 
EL5 H31  H  N N 156 
EL5 H32  H  N N 157 
EL5 H33  H  N N 158 
EL5 H34  H  N N 159 
EL5 H35  H  N N 160 
EL5 H36  H  N N 161 
EL5 H37  H  N N 162 
EL5 H38  H  N N 163 
EL5 H39  H  N N 164 
EL5 H40  H  N N 165 
EL5 H42  H  N N 166 
EL5 H5   H  N N 167 
GLN N    N  N N 168 
GLN CA   C  N S 169 
GLN C    C  N N 170 
GLN O    O  N N 171 
GLN CB   C  N N 172 
GLN CG   C  N N 173 
GLN CD   C  N N 174 
GLN OE1  O  N N 175 
GLN NE2  N  N N 176 
GLN OXT  O  N N 177 
GLN H    H  N N 178 
GLN H2   H  N N 179 
GLN HA   H  N N 180 
GLN HB2  H  N N 181 
GLN HB3  H  N N 182 
GLN HG2  H  N N 183 
GLN HG3  H  N N 184 
GLN HE21 H  N N 185 
GLN HE22 H  N N 186 
GLN HXT  H  N N 187 
GLU N    N  N N 188 
GLU CA   C  N S 189 
GLU C    C  N N 190 
GLU O    O  N N 191 
GLU CB   C  N N 192 
GLU CG   C  N N 193 
GLU CD   C  N N 194 
GLU OE1  O  N N 195 
GLU OE2  O  N N 196 
GLU OXT  O  N N 197 
GLU H    H  N N 198 
GLU H2   H  N N 199 
GLU HA   H  N N 200 
GLU HB2  H  N N 201 
GLU HB3  H  N N 202 
GLU HG2  H  N N 203 
GLU HG3  H  N N 204 
GLU HE2  H  N N 205 
GLU HXT  H  N N 206 
GLY N    N  N N 207 
GLY CA   C  N N 208 
GLY C    C  N N 209 
GLY O    O  N N 210 
GLY OXT  O  N N 211 
GLY H    H  N N 212 
GLY H2   H  N N 213 
GLY HA2  H  N N 214 
GLY HA3  H  N N 215 
GLY HXT  H  N N 216 
HIS N    N  N N 217 
HIS CA   C  N S 218 
HIS C    C  N N 219 
HIS O    O  N N 220 
HIS CB   C  N N 221 
HIS CG   C  Y N 222 
HIS ND1  N  Y N 223 
HIS CD2  C  Y N 224 
HIS CE1  C  Y N 225 
HIS NE2  N  Y N 226 
HIS OXT  O  N N 227 
HIS H    H  N N 228 
HIS H2   H  N N 229 
HIS HA   H  N N 230 
HIS HB2  H  N N 231 
HIS HB3  H  N N 232 
HIS HD1  H  N N 233 
HIS HD2  H  N N 234 
HIS HE1  H  N N 235 
HIS HE2  H  N N 236 
HIS HXT  H  N N 237 
HOH O    O  N N 238 
HOH H1   H  N N 239 
HOH H2   H  N N 240 
ILE N    N  N N 241 
ILE CA   C  N S 242 
ILE C    C  N N 243 
ILE O    O  N N 244 
ILE CB   C  N S 245 
ILE CG1  C  N N 246 
ILE CG2  C  N N 247 
ILE CD1  C  N N 248 
ILE OXT  O  N N 249 
ILE H    H  N N 250 
ILE H2   H  N N 251 
ILE HA   H  N N 252 
ILE HB   H  N N 253 
ILE HG12 H  N N 254 
ILE HG13 H  N N 255 
ILE HG21 H  N N 256 
ILE HG22 H  N N 257 
ILE HG23 H  N N 258 
ILE HD11 H  N N 259 
ILE HD12 H  N N 260 
ILE HD13 H  N N 261 
ILE HXT  H  N N 262 
LEU N    N  N N 263 
LEU CA   C  N S 264 
LEU C    C  N N 265 
LEU O    O  N N 266 
LEU CB   C  N N 267 
LEU CG   C  N N 268 
LEU CD1  C  N N 269 
LEU CD2  C  N N 270 
LEU OXT  O  N N 271 
LEU H    H  N N 272 
LEU H2   H  N N 273 
LEU HA   H  N N 274 
LEU HB2  H  N N 275 
LEU HB3  H  N N 276 
LEU HG   H  N N 277 
LEU HD11 H  N N 278 
LEU HD12 H  N N 279 
LEU HD13 H  N N 280 
LEU HD21 H  N N 281 
LEU HD22 H  N N 282 
LEU HD23 H  N N 283 
LEU HXT  H  N N 284 
LYS N    N  N N 285 
LYS CA   C  N S 286 
LYS C    C  N N 287 
LYS O    O  N N 288 
LYS CB   C  N N 289 
LYS CG   C  N N 290 
LYS CD   C  N N 291 
LYS CE   C  N N 292 
LYS NZ   N  N N 293 
LYS OXT  O  N N 294 
LYS H    H  N N 295 
LYS H2   H  N N 296 
LYS HA   H  N N 297 
LYS HB2  H  N N 298 
LYS HB3  H  N N 299 
LYS HG2  H  N N 300 
LYS HG3  H  N N 301 
LYS HD2  H  N N 302 
LYS HD3  H  N N 303 
LYS HE2  H  N N 304 
LYS HE3  H  N N 305 
LYS HZ1  H  N N 306 
LYS HZ2  H  N N 307 
LYS HZ3  H  N N 308 
LYS HXT  H  N N 309 
MET N    N  N N 310 
MET CA   C  N S 311 
MET C    C  N N 312 
MET O    O  N N 313 
MET CB   C  N N 314 
MET CG   C  N N 315 
MET SD   S  N N 316 
MET CE   C  N N 317 
MET OXT  O  N N 318 
MET H    H  N N 319 
MET H2   H  N N 320 
MET HA   H  N N 321 
MET HB2  H  N N 322 
MET HB3  H  N N 323 
MET HG2  H  N N 324 
MET HG3  H  N N 325 
MET HE1  H  N N 326 
MET HE2  H  N N 327 
MET HE3  H  N N 328 
MET HXT  H  N N 329 
PHE N    N  N N 330 
PHE CA   C  N S 331 
PHE C    C  N N 332 
PHE O    O  N N 333 
PHE CB   C  N N 334 
PHE CG   C  Y N 335 
PHE CD1  C  Y N 336 
PHE CD2  C  Y N 337 
PHE CE1  C  Y N 338 
PHE CE2  C  Y N 339 
PHE CZ   C  Y N 340 
PHE OXT  O  N N 341 
PHE H    H  N N 342 
PHE H2   H  N N 343 
PHE HA   H  N N 344 
PHE HB2  H  N N 345 
PHE HB3  H  N N 346 
PHE HD1  H  N N 347 
PHE HD2  H  N N 348 
PHE HE1  H  N N 349 
PHE HE2  H  N N 350 
PHE HZ   H  N N 351 
PHE HXT  H  N N 352 
PRO N    N  N N 353 
PRO CA   C  N S 354 
PRO C    C  N N 355 
PRO O    O  N N 356 
PRO CB   C  N N 357 
PRO CG   C  N N 358 
PRO CD   C  N N 359 
PRO OXT  O  N N 360 
PRO H    H  N N 361 
PRO HA   H  N N 362 
PRO HB2  H  N N 363 
PRO HB3  H  N N 364 
PRO HG2  H  N N 365 
PRO HG3  H  N N 366 
PRO HD2  H  N N 367 
PRO HD3  H  N N 368 
PRO HXT  H  N N 369 
SER N    N  N N 370 
SER CA   C  N S 371 
SER C    C  N N 372 
SER O    O  N N 373 
SER CB   C  N N 374 
SER OG   O  N N 375 
SER OXT  O  N N 376 
SER H    H  N N 377 
SER H2   H  N N 378 
SER HA   H  N N 379 
SER HB2  H  N N 380 
SER HB3  H  N N 381 
SER HG   H  N N 382 
SER HXT  H  N N 383 
SO4 S    S  N N 384 
SO4 O1   O  N N 385 
SO4 O2   O  N N 386 
SO4 O3   O  N N 387 
SO4 O4   O  N N 388 
THR N    N  N N 389 
THR CA   C  N S 390 
THR C    C  N N 391 
THR O    O  N N 392 
THR CB   C  N R 393 
THR OG1  O  N N 394 
THR CG2  C  N N 395 
THR OXT  O  N N 396 
THR H    H  N N 397 
THR H2   H  N N 398 
THR HA   H  N N 399 
THR HB   H  N N 400 
THR HG1  H  N N 401 
THR HG21 H  N N 402 
THR HG22 H  N N 403 
THR HG23 H  N N 404 
THR HXT  H  N N 405 
TRP N    N  N N 406 
TRP CA   C  N S 407 
TRP C    C  N N 408 
TRP O    O  N N 409 
TRP CB   C  N N 410 
TRP CG   C  Y N 411 
TRP CD1  C  Y N 412 
TRP CD2  C  Y N 413 
TRP NE1  N  Y N 414 
TRP CE2  C  Y N 415 
TRP CE3  C  Y N 416 
TRP CZ2  C  Y N 417 
TRP CZ3  C  Y N 418 
TRP CH2  C  Y N 419 
TRP OXT  O  N N 420 
TRP H    H  N N 421 
TRP H2   H  N N 422 
TRP HA   H  N N 423 
TRP HB2  H  N N 424 
TRP HB3  H  N N 425 
TRP HD1  H  N N 426 
TRP HE1  H  N N 427 
TRP HE3  H  N N 428 
TRP HZ2  H  N N 429 
TRP HZ3  H  N N 430 
TRP HH2  H  N N 431 
TRP HXT  H  N N 432 
TYR N    N  N N 433 
TYR CA   C  N S 434 
TYR C    C  N N 435 
TYR O    O  N N 436 
TYR CB   C  N N 437 
TYR CG   C  Y N 438 
TYR CD1  C  Y N 439 
TYR CD2  C  Y N 440 
TYR CE1  C  Y N 441 
TYR CE2  C  Y N 442 
TYR CZ   C  Y N 443 
TYR OH   O  N N 444 
TYR OXT  O  N N 445 
TYR H    H  N N 446 
TYR H2   H  N N 447 
TYR HA   H  N N 448 
TYR HB2  H  N N 449 
TYR HB3  H  N N 450 
TYR HD1  H  N N 451 
TYR HD2  H  N N 452 
TYR HE1  H  N N 453 
TYR HE2  H  N N 454 
TYR HH   H  N N 455 
TYR HXT  H  N N 456 
VAL N    N  N N 457 
VAL CA   C  N S 458 
VAL C    C  N N 459 
VAL O    O  N N 460 
VAL CB   C  N N 461 
VAL CG1  C  N N 462 
VAL CG2  C  N N 463 
VAL OXT  O  N N 464 
VAL H    H  N N 465 
VAL H2   H  N N 466 
VAL HA   H  N N 467 
VAL HB   H  N N 468 
VAL HG11 H  N N 469 
VAL HG12 H  N N 470 
VAL HG13 H  N N 471 
VAL HG21 H  N N 472 
VAL HG22 H  N N 473 
VAL HG23 H  N N 474 
VAL HXT  H  N N 475 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
EL5 OD  C4D  doub N N 83  
EL5 ND  C4D  sing N N 84  
EL5 ND  C1D  sing N N 85  
EL5 CMA C2A  sing N N 86  
EL5 CBA CAA  sing N N 87  
EL5 C4D C3D  sing N N 88  
EL5 C2A C1A  sing N N 89  
EL5 C2A C3A  sing N N 90  
EL5 OA  C1A  doub N N 91  
EL5 CBD CAD  doub N N 92  
EL5 CAA C3A  doub N E 93  
EL5 C1A NA   sing N N 94  
EL5 CHD C1D  doub N E 95  
EL5 CHD C4C  sing N N 96  
EL5 C3A C4A  sing N N 97  
EL5 C1D C2D  sing N N 98  
EL5 C3D CAD  sing N N 99  
EL5 C3D C2D  doub N N 100 
EL5 CMC C3C  sing N N 101 
EL5 NA  C4A  sing N N 102 
EL5 C4A CHB  doub N Z 103 
EL5 C4C C3C  doub Y N 104 
EL5 C4C NC   sing Y N 105 
EL5 C2D CMD  sing N N 106 
EL5 C3C C2C  sing Y N 107 
EL5 NC  C1C  sing Y N 108 
EL5 CHB C1B  sing N N 109 
EL5 C2C C1C  doub Y N 110 
EL5 C2C CAC  sing N N 111 
EL5 NB  C1B  doub N N 112 
EL5 NB  C4B  sing N N 113 
EL5 C1C CHC  sing N N 114 
EL5 C1B C2B  sing N N 115 
EL5 CAC CBC  sing N N 116 
EL5 C4B CHC  doub N Z 117 
EL5 C4B C3B  sing N N 118 
EL5 C2B C3B  doub N N 119 
EL5 C2B CMB  sing N N 120 
EL5 O1C CGC  doub N N 121 
EL5 C3B CAB  sing N N 122 
EL5 CBC CGC  sing N N 123 
EL5 CGC O2C  sing N N 124 
EL5 CAB CBB  sing N N 125 
EL5 CBB CGB  sing N N 126 
EL5 CGB O2B  doub N N 127 
EL5 CGB O1B  sing N N 128 
EL5 O1B H1   sing N N 129 
EL5 C2A H2   sing N N 130 
EL5 O2C H3   sing N N 131 
EL5 CAA H4   sing N N 132 
EL5 CAB H6   sing N N 133 
EL5 CAB H7   sing N N 134 
EL5 CAC H8   sing N N 135 
EL5 CAC H9   sing N N 136 
EL5 CAD H10  sing N N 137 
EL5 CBA H12  sing N N 138 
EL5 CBA H13  sing N N 139 
EL5 CBA H14  sing N N 140 
EL5 CBB H15  sing N N 141 
EL5 CBB H16  sing N N 142 
EL5 CBC H17  sing N N 143 
EL5 CBC H18  sing N N 144 
EL5 CBD H19  sing N N 145 
EL5 CBD H20  sing N N 146 
EL5 CHB H22  sing N N 147 
EL5 CHC H24  sing N N 148 
EL5 CHD H26  sing N N 149 
EL5 CMA H28  sing N N 150 
EL5 CMA H29  sing N N 151 
EL5 CMA H30  sing N N 152 
EL5 CMB H31  sing N N 153 
EL5 CMB H32  sing N N 154 
EL5 CMB H33  sing N N 155 
EL5 CMC H34  sing N N 156 
EL5 CMC H35  sing N N 157 
EL5 CMC H36  sing N N 158 
EL5 CMD H37  sing N N 159 
EL5 CMD H38  sing N N 160 
EL5 CMD H39  sing N N 161 
EL5 NA  H40  sing N N 162 
EL5 NC  H42  sing N N 163 
EL5 ND  H5   sing N N 164 
GLN N   CA   sing N N 165 
GLN N   H    sing N N 166 
GLN N   H2   sing N N 167 
GLN CA  C    sing N N 168 
GLN CA  CB   sing N N 169 
GLN CA  HA   sing N N 170 
GLN C   O    doub N N 171 
GLN C   OXT  sing N N 172 
GLN CB  CG   sing N N 173 
GLN CB  HB2  sing N N 174 
GLN CB  HB3  sing N N 175 
GLN CG  CD   sing N N 176 
GLN CG  HG2  sing N N 177 
GLN CG  HG3  sing N N 178 
GLN CD  OE1  doub N N 179 
GLN CD  NE2  sing N N 180 
GLN NE2 HE21 sing N N 181 
GLN NE2 HE22 sing N N 182 
GLN OXT HXT  sing N N 183 
GLU N   CA   sing N N 184 
GLU N   H    sing N N 185 
GLU N   H2   sing N N 186 
GLU CA  C    sing N N 187 
GLU CA  CB   sing N N 188 
GLU CA  HA   sing N N 189 
GLU C   O    doub N N 190 
GLU C   OXT  sing N N 191 
GLU CB  CG   sing N N 192 
GLU CB  HB2  sing N N 193 
GLU CB  HB3  sing N N 194 
GLU CG  CD   sing N N 195 
GLU CG  HG2  sing N N 196 
GLU CG  HG3  sing N N 197 
GLU CD  OE1  doub N N 198 
GLU CD  OE2  sing N N 199 
GLU OE2 HE2  sing N N 200 
GLU OXT HXT  sing N N 201 
GLY N   CA   sing N N 202 
GLY N   H    sing N N 203 
GLY N   H2   sing N N 204 
GLY CA  C    sing N N 205 
GLY CA  HA2  sing N N 206 
GLY CA  HA3  sing N N 207 
GLY C   O    doub N N 208 
GLY C   OXT  sing N N 209 
GLY OXT HXT  sing N N 210 
HIS N   CA   sing N N 211 
HIS N   H    sing N N 212 
HIS N   H2   sing N N 213 
HIS CA  C    sing N N 214 
HIS CA  CB   sing N N 215 
HIS CA  HA   sing N N 216 
HIS C   O    doub N N 217 
HIS C   OXT  sing N N 218 
HIS CB  CG   sing N N 219 
HIS CB  HB2  sing N N 220 
HIS CB  HB3  sing N N 221 
HIS CG  ND1  sing Y N 222 
HIS CG  CD2  doub Y N 223 
HIS ND1 CE1  doub Y N 224 
HIS ND1 HD1  sing N N 225 
HIS CD2 NE2  sing Y N 226 
HIS CD2 HD2  sing N N 227 
HIS CE1 NE2  sing Y N 228 
HIS CE1 HE1  sing N N 229 
HIS NE2 HE2  sing N N 230 
HIS OXT HXT  sing N N 231 
HOH O   H1   sing N N 232 
HOH O   H2   sing N N 233 
ILE N   CA   sing N N 234 
ILE N   H    sing N N 235 
ILE N   H2   sing N N 236 
ILE CA  C    sing N N 237 
ILE CA  CB   sing N N 238 
ILE CA  HA   sing N N 239 
ILE C   O    doub N N 240 
ILE C   OXT  sing N N 241 
ILE CB  CG1  sing N N 242 
ILE CB  CG2  sing N N 243 
ILE CB  HB   sing N N 244 
ILE CG1 CD1  sing N N 245 
ILE CG1 HG12 sing N N 246 
ILE CG1 HG13 sing N N 247 
ILE CG2 HG21 sing N N 248 
ILE CG2 HG22 sing N N 249 
ILE CG2 HG23 sing N N 250 
ILE CD1 HD11 sing N N 251 
ILE CD1 HD12 sing N N 252 
ILE CD1 HD13 sing N N 253 
ILE OXT HXT  sing N N 254 
LEU N   CA   sing N N 255 
LEU N   H    sing N N 256 
LEU N   H2   sing N N 257 
LEU CA  C    sing N N 258 
LEU CA  CB   sing N N 259 
LEU CA  HA   sing N N 260 
LEU C   O    doub N N 261 
LEU C   OXT  sing N N 262 
LEU CB  CG   sing N N 263 
LEU CB  HB2  sing N N 264 
LEU CB  HB3  sing N N 265 
LEU CG  CD1  sing N N 266 
LEU CG  CD2  sing N N 267 
LEU CG  HG   sing N N 268 
LEU CD1 HD11 sing N N 269 
LEU CD1 HD12 sing N N 270 
LEU CD1 HD13 sing N N 271 
LEU CD2 HD21 sing N N 272 
LEU CD2 HD22 sing N N 273 
LEU CD2 HD23 sing N N 274 
LEU OXT HXT  sing N N 275 
LYS N   CA   sing N N 276 
LYS N   H    sing N N 277 
LYS N   H2   sing N N 278 
LYS CA  C    sing N N 279 
LYS CA  CB   sing N N 280 
LYS CA  HA   sing N N 281 
LYS C   O    doub N N 282 
LYS C   OXT  sing N N 283 
LYS CB  CG   sing N N 284 
LYS CB  HB2  sing N N 285 
LYS CB  HB3  sing N N 286 
LYS CG  CD   sing N N 287 
LYS CG  HG2  sing N N 288 
LYS CG  HG3  sing N N 289 
LYS CD  CE   sing N N 290 
LYS CD  HD2  sing N N 291 
LYS CD  HD3  sing N N 292 
LYS CE  NZ   sing N N 293 
LYS CE  HE2  sing N N 294 
LYS CE  HE3  sing N N 295 
LYS NZ  HZ1  sing N N 296 
LYS NZ  HZ2  sing N N 297 
LYS NZ  HZ3  sing N N 298 
LYS OXT HXT  sing N N 299 
MET N   CA   sing N N 300 
MET N   H    sing N N 301 
MET N   H2   sing N N 302 
MET CA  C    sing N N 303 
MET CA  CB   sing N N 304 
MET CA  HA   sing N N 305 
MET C   O    doub N N 306 
MET C   OXT  sing N N 307 
MET CB  CG   sing N N 308 
MET CB  HB2  sing N N 309 
MET CB  HB3  sing N N 310 
MET CG  SD   sing N N 311 
MET CG  HG2  sing N N 312 
MET CG  HG3  sing N N 313 
MET SD  CE   sing N N 314 
MET CE  HE1  sing N N 315 
MET CE  HE2  sing N N 316 
MET CE  HE3  sing N N 317 
MET OXT HXT  sing N N 318 
PHE N   CA   sing N N 319 
PHE N   H    sing N N 320 
PHE N   H2   sing N N 321 
PHE CA  C    sing N N 322 
PHE CA  CB   sing N N 323 
PHE CA  HA   sing N N 324 
PHE C   O    doub N N 325 
PHE C   OXT  sing N N 326 
PHE CB  CG   sing N N 327 
PHE CB  HB2  sing N N 328 
PHE CB  HB3  sing N N 329 
PHE CG  CD1  doub Y N 330 
PHE CG  CD2  sing Y N 331 
PHE CD1 CE1  sing Y N 332 
PHE CD1 HD1  sing N N 333 
PHE CD2 CE2  doub Y N 334 
PHE CD2 HD2  sing N N 335 
PHE CE1 CZ   doub Y N 336 
PHE CE1 HE1  sing N N 337 
PHE CE2 CZ   sing Y N 338 
PHE CE2 HE2  sing N N 339 
PHE CZ  HZ   sing N N 340 
PHE OXT HXT  sing N N 341 
PRO N   CA   sing N N 342 
PRO N   CD   sing N N 343 
PRO N   H    sing N N 344 
PRO CA  C    sing N N 345 
PRO CA  CB   sing N N 346 
PRO CA  HA   sing N N 347 
PRO C   O    doub N N 348 
PRO C   OXT  sing N N 349 
PRO CB  CG   sing N N 350 
PRO CB  HB2  sing N N 351 
PRO CB  HB3  sing N N 352 
PRO CG  CD   sing N N 353 
PRO CG  HG2  sing N N 354 
PRO CG  HG3  sing N N 355 
PRO CD  HD2  sing N N 356 
PRO CD  HD3  sing N N 357 
PRO OXT HXT  sing N N 358 
SER N   CA   sing N N 359 
SER N   H    sing N N 360 
SER N   H2   sing N N 361 
SER CA  C    sing N N 362 
SER CA  CB   sing N N 363 
SER CA  HA   sing N N 364 
SER C   O    doub N N 365 
SER C   OXT  sing N N 366 
SER CB  OG   sing N N 367 
SER CB  HB2  sing N N 368 
SER CB  HB3  sing N N 369 
SER OG  HG   sing N N 370 
SER OXT HXT  sing N N 371 
SO4 S   O1   doub N N 372 
SO4 S   O2   doub N N 373 
SO4 S   O3   sing N N 374 
SO4 S   O4   sing N N 375 
THR N   CA   sing N N 376 
THR N   H    sing N N 377 
THR N   H2   sing N N 378 
THR CA  C    sing N N 379 
THR CA  CB   sing N N 380 
THR CA  HA   sing N N 381 
THR C   O    doub N N 382 
THR C   OXT  sing N N 383 
THR CB  OG1  sing N N 384 
THR CB  CG2  sing N N 385 
THR CB  HB   sing N N 386 
THR OG1 HG1  sing N N 387 
THR CG2 HG21 sing N N 388 
THR CG2 HG22 sing N N 389 
THR CG2 HG23 sing N N 390 
THR OXT HXT  sing N N 391 
TRP N   CA   sing N N 392 
TRP N   H    sing N N 393 
TRP N   H2   sing N N 394 
TRP CA  C    sing N N 395 
TRP CA  CB   sing N N 396 
TRP CA  HA   sing N N 397 
TRP C   O    doub N N 398 
TRP C   OXT  sing N N 399 
TRP CB  CG   sing N N 400 
TRP CB  HB2  sing N N 401 
TRP CB  HB3  sing N N 402 
TRP CG  CD1  doub Y N 403 
TRP CG  CD2  sing Y N 404 
TRP CD1 NE1  sing Y N 405 
TRP CD1 HD1  sing N N 406 
TRP CD2 CE2  doub Y N 407 
TRP CD2 CE3  sing Y N 408 
TRP NE1 CE2  sing Y N 409 
TRP NE1 HE1  sing N N 410 
TRP CE2 CZ2  sing Y N 411 
TRP CE3 CZ3  doub Y N 412 
TRP CE3 HE3  sing N N 413 
TRP CZ2 CH2  doub Y N 414 
TRP CZ2 HZ2  sing N N 415 
TRP CZ3 CH2  sing Y N 416 
TRP CZ3 HZ3  sing N N 417 
TRP CH2 HH2  sing N N 418 
TRP OXT HXT  sing N N 419 
TYR N   CA   sing N N 420 
TYR N   H    sing N N 421 
TYR N   H2   sing N N 422 
TYR CA  C    sing N N 423 
TYR CA  CB   sing N N 424 
TYR CA  HA   sing N N 425 
TYR C   O    doub N N 426 
TYR C   OXT  sing N N 427 
TYR CB  CG   sing N N 428 
TYR CB  HB2  sing N N 429 
TYR CB  HB3  sing N N 430 
TYR CG  CD1  doub Y N 431 
TYR CG  CD2  sing Y N 432 
TYR CD1 CE1  sing Y N 433 
TYR CD1 HD1  sing N N 434 
TYR CD2 CE2  doub Y N 435 
TYR CD2 HD2  sing N N 436 
TYR CE1 CZ   doub Y N 437 
TYR CE1 HE1  sing N N 438 
TYR CE2 CZ   sing Y N 439 
TYR CE2 HE2  sing N N 440 
TYR CZ  OH   sing N N 441 
TYR OH  HH   sing N N 442 
TYR OXT HXT  sing N N 443 
VAL N   CA   sing N N 444 
VAL N   H    sing N N 445 
VAL N   H2   sing N N 446 
VAL CA  C    sing N N 447 
VAL CA  CB   sing N N 448 
VAL CA  HA   sing N N 449 
VAL C   O    doub N N 450 
VAL C   OXT  sing N N 451 
VAL CB  CG1  sing N N 452 
VAL CB  CG2  sing N N 453 
VAL CB  HB   sing N N 454 
VAL CG1 HG11 sing N N 455 
VAL CG1 HG12 sing N N 456 
VAL CG1 HG13 sing N N 457 
VAL CG2 HG21 sing N N 458 
VAL CG2 HG22 sing N N 459 
VAL CG2 HG23 sing N N 460 
VAL OXT HXT  sing N N 461 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'German Research Foundation (DFG)'                     Germany          CRC1078                                               1 
'German Research Foundation (DFG)'                     Germany          CRC1423                                               2 
'German Research Foundation (DFG)'                     Germany          'EXC 311 2008/1'                                      3 
'Boehringer Ingelheim Fonds (BIF)'                     Germany          'BIF Travel Grant'                                    4 
'Israel Science Foundation'                            Israel           3131/20                                               5 
'Department of Energy (DOE, United States)'            'United States'  'DE-AC02-76SF00515, DE-AC02-05CH11231'                6 
'National Institutes of Health/Office of the Director' 'United States'  'GM05530, GM110501, GM126289, GM117126, S10 OD023453' 7 
'Wellcome Trust'                                       'United Kingdom' 210734/Z/18/Z                                         8 
'Royal Society'                                        'United Kingdom' 'RSWF- R2 - 182017'                                   9 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   6G1Z 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8RJS 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.005432 
_atom_sites.fract_transf_matrix[1][2]   0.003136 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.006272 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.005526 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
CL 
N  
O  
S  
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . VAL A 1 8   ? -54.864 24.507  -20.417 1.00 107.30 ?  8   VAL A N   1 
ATOM   2    C  CA  . VAL A 1 8   ? -53.689 24.290  -19.509 1.00 108.45 ?  8   VAL A CA  1 
ATOM   3    C  C   . VAL A 1 8   ? -53.051 25.650  -19.184 1.00 106.70 ?  8   VAL A C   1 
ATOM   4    O  O   . VAL A 1 8   ? -52.768 26.412  -20.128 1.00 105.33 ?  8   VAL A O   1 
ATOM   5    C  CB  . VAL A 1 8   ? -52.669 23.301  -20.115 1.00 108.42 ?  8   VAL A CB  1 
ATOM   6    C  CG1 . VAL A 1 8   ? -52.134 23.756  -21.467 1.00 106.47 ?  8   VAL A CG1 1 
ATOM   7    C  CG2 . VAL A 1 8   ? -51.521 23.016  -19.156 1.00 107.15 ?  8   VAL A CG2 1 
ATOM   8    N  N   . ASP A 1 9   ? -52.856 25.940  -17.893 1.00 108.17 ?  9   ASP A N   1 
ATOM   9    C  CA  . ASP A 1 9   ? -52.133 27.143  -17.390 1.00 112.07 ?  9   ASP A CA  1 
ATOM   10   C  C   . ASP A 1 9   ? -51.444 26.781  -16.066 1.00 112.41 ?  9   ASP A C   1 
ATOM   11   O  O   . ASP A 1 9   ? -51.569 25.614  -15.640 1.00 114.84 ?  9   ASP A O   1 
ATOM   12   C  CB  . ASP A 1 9   ? -53.065 28.356  -17.290 1.00 113.11 ?  9   ASP A CB  1 
ATOM   13   C  CG  . ASP A 1 9   ? -54.422 28.058  -16.675 1.00 114.41 ?  9   ASP A CG  1 
ATOM   14   O  OD1 . ASP A 1 9   ? -54.464 27.298  -15.688 1.00 113.00 ?  9   ASP A OD1 1 
ATOM   15   O  OD2 . ASP A 1 9   ? -55.427 28.587  -17.193 1.00 114.56 ?  9   ASP A OD2 1 
ATOM   16   N  N   . LEU A 1 10  ? -50.762 27.747  -15.436 1.00 111.82 ?  10  LEU A N   1 
ATOM   17   C  CA  . LEU A 1 10  ? -49.863 27.536  -14.261 1.00 109.31 ?  10  LEU A CA  1 
ATOM   18   C  C   . LEU A 1 10  ? -50.603 26.834  -13.114 1.00 109.65 ?  10  LEU A C   1 
ATOM   19   O  O   . LEU A 1 10  ? -49.914 26.335  -12.199 1.00 111.20 ?  10  LEU A O   1 
ATOM   20   C  CB  . LEU A 1 10  ? -49.310 28.884  -13.783 1.00 107.23 ?  10  LEU A CB  1 
ATOM   21   C  CG  . LEU A 1 10  ? -48.617 29.749  -14.836 1.00 107.19 ?  10  LEU A CG  1 
ATOM   22   C  CD1 . LEU A 1 10  ? -47.906 30.920  -14.176 1.00 108.22 ?  10  LEU A CD1 1 
ATOM   23   C  CD2 . LEU A 1 10  ? -47.638 28.939  -15.673 1.00 107.38 ?  10  LEU A CD2 1 
ATOM   24   N  N   . THR A 1 11  ? -51.939 26.799  -13.160 1.00 109.43 ?  11  THR A N   1 
ATOM   25   C  CA  . THR A 1 11  ? -52.816 26.224  -12.097 1.00 108.55 ?  11  THR A CA  1 
ATOM   26   C  C   . THR A 1 11  ? -52.965 24.706  -12.284 1.00 107.39 ?  11  THR A C   1 
ATOM   27   O  O   . THR A 1 11  ? -53.070 24.004  -11.256 1.00 109.26 ?  11  THR A O   1 
ATOM   28   C  CB  . THR A 1 11  ? -54.181 26.922  -12.073 1.00 107.71 ?  11  THR A CB  1 
ATOM   29   O  OG1 . THR A 1 11  ? -54.808 26.731  -13.341 1.00 106.29 ?  11  THR A OG1 1 
ATOM   30   C  CG2 . THR A 1 11  ? -54.074 28.402  -11.775 1.00 108.29 ?  11  THR A CG2 1 
ATOM   31   N  N   . ASN A 1 12  ? -52.978 24.218  -13.531 1.00 106.96 ?  12  ASN A N   1 
ATOM   32   C  CA  . ASN A 1 12  ? -53.251 22.789  -13.859 1.00 110.11 ?  12  ASN A CA  1 
ATOM   33   C  C   . ASN A 1 12  ? -52.165 22.213  -14.783 1.00 109.67 ?  12  ASN A C   1 
ATOM   34   O  O   . ASN A 1 12  ? -52.430 21.163  -15.407 1.00 109.75 ?  12  ASN A O   1 
ATOM   35   C  CB  . ASN A 1 12  ? -54.650 22.620  -14.462 1.00 109.87 ?  12  ASN A CB  1 
ATOM   36   C  CG  . ASN A 1 12  ? -54.810 23.293  -15.811 1.00 110.23 ?  12  ASN A CG  1 
ATOM   37   O  OD1 . ASN A 1 12  ? -54.190 24.320  -16.078 1.00 110.94 ?  12  ASN A OD1 1 
ATOM   38   N  ND2 . ASN A 1 12  ? -55.648 22.727  -16.665 1.00 112.25 ?  12  ASN A ND2 1 
ATOM   39   N  N   . CYS A 1 13  ? -50.983 22.840  -14.847 1.00 106.75 ?  13  CYS A N   1 
ATOM   40   C  CA  . CYS A 1 13  ? -49.830 22.383  -15.683 1.00 104.66 ?  13  CYS A CA  1 
ATOM   41   C  C   . CYS A 1 13  ? -49.076 21.237  -14.988 1.00 102.60 ?  13  CYS A C   1 
ATOM   42   O  O   . CYS A 1 13  ? -48.294 20.541  -15.678 1.00 96.06  ?  13  CYS A O   1 
ATOM   43   C  CB  . CYS A 1 13  ? -48.871 23.529  -15.997 1.00 103.14 ?  13  CYS A CB  1 
ATOM   44   S  SG  . CYS A 1 13  ? -47.836 24.062  -14.597 1.00 104.92 ?  13  CYS A SG  1 
ATOM   45   N  N   . ASP A 1 14  ? -49.303 21.059  -13.679 1.00 101.66 ?  14  ASP A N   1 
ATOM   46   C  CA  . ASP A 1 14  ? -48.689 20.005  -12.821 1.00 98.03  ?  14  ASP A CA  1 
ATOM   47   C  C   . ASP A 1 14  ? -49.398 18.660  -13.043 1.00 94.95  ?  14  ASP A C   1 
ATOM   48   O  O   . ASP A 1 14  ? -48.800 17.617  -12.700 1.00 86.87  ?  14  ASP A O   1 
ATOM   49   C  CB  . ASP A 1 14  ? -48.731 20.398  -11.339 1.00 98.94  ?  14  ASP A CB  1 
ATOM   50   C  CG  . ASP A 1 14  ? -50.120 20.729  -10.808 1.00 98.07  ?  14  ASP A CG  1 
ATOM   51   O  OD1 . ASP A 1 14  ? -50.761 21.645  -11.365 1.00 92.64  ?  14  ASP A OD1 1 
ATOM   52   O  OD2 . ASP A 1 14  ? -50.548 20.072  -9.838  1.00 95.93  ?  14  ASP A OD2 1 
ATOM   53   N  N   . ARG A 1 15  ? -50.625 18.691  -13.578 1.00 95.82  ?  15  ARG A N   1 
ATOM   54   C  CA  . ARG A 1 15  ? -51.448 17.476  -13.870 1.00 93.24  ?  15  ARG A CA  1 
ATOM   55   C  C   . ARG A 1 15  ? -51.710 17.358  -15.380 1.00 89.08  ?  15  ARG A C   1 
ATOM   56   O  O   . ARG A 1 15  ? -52.555 16.524  -15.767 1.00 87.31  ?  15  ARG A O   1 
ATOM   57   C  CB  . ARG A 1 15  ? -52.763 17.533  -13.084 1.00 92.24  ?  15  ARG A CB  1 
ATOM   58   N  N   . GLU A 1 16  ? -50.998 18.141  -16.198 1.00 84.69  ?  16  GLU A N   1 
ATOM   59   C  CA  . GLU A 1 16  ? -51.120 18.151  -17.683 1.00 82.62  ?  16  GLU A CA  1 
ATOM   60   C  C   . GLU A 1 16  ? -50.861 16.744  -18.224 1.00 82.95  ?  16  GLU A C   1 
ATOM   61   O  O   . GLU A 1 16  ? -49.867 16.115  -17.867 1.00 80.60  ?  16  GLU A O   1 
ATOM   62   C  CB  . GLU A 1 16  ? -50.142 19.160  -18.291 1.00 80.44  ?  16  GLU A CB  1 
ATOM   63   C  CG  . GLU A 1 16  ? -50.288 19.331  -19.796 1.00 79.29  ?  16  GLU A CG  1 
ATOM   64   C  CD  . GLU A 1 16  ? -49.262 20.252  -20.436 1.00 79.37  ?  16  GLU A CD  1 
ATOM   65   O  OE1 . GLU A 1 16  ? -48.450 20.843  -19.696 1.00 80.87  ?  16  GLU A OE1 1 
ATOM   66   O  OE2 . GLU A 1 16  ? -49.276 20.375  -21.677 1.00 78.26  ?  16  GLU A OE2 1 
ATOM   67   N  N   . PRO A 1 17  ? -51.740 16.206  -19.102 1.00 83.57  ?  17  PRO A N   1 
ATOM   68   C  CA  . PRO A 1 17  ? -51.545 14.873  -19.675 1.00 83.24  ?  17  PRO A CA  1 
ATOM   69   C  C   . PRO A 1 17  ? -50.657 14.915  -20.929 1.00 83.67  ?  17  PRO A C   1 
ATOM   70   O  O   . PRO A 1 17  ? -51.149 14.654  -22.013 1.00 87.95  ?  17  PRO A O   1 
ATOM   71   C  CB  . PRO A 1 17  ? -52.993 14.477  -19.996 1.00 83.73  ?  17  PRO A CB  1 
ATOM   72   C  CG  . PRO A 1 17  ? -53.620 15.780  -20.458 1.00 82.57  ?  17  PRO A CG  1 
ATOM   73   C  CD  . PRO A 1 17  ? -52.972 16.846  -19.595 1.00 82.25  ?  17  PRO A CD  1 
ATOM   74   N  N   . ILE A 1 18  ? -49.368 15.222  -20.743 1.00 79.53  ?  18  ILE A N   1 
ATOM   75   C  CA  . ILE A 1 18  ? -48.392 15.522  -21.839 1.00 74.78  ?  18  ILE A CA  1 
ATOM   76   C  C   . ILE A 1 18  ? -48.202 14.302  -22.752 1.00 73.71  ?  18  ILE A C   1 
ATOM   77   O  O   . ILE A 1 18  ? -47.728 14.498  -23.887 1.00 72.35  ?  18  ILE A O   1 
ATOM   78   C  CB  . ILE A 1 18  ? -47.045 16.002  -21.267 1.00 72.65  ?  18  ILE A CB  1 
ATOM   79   C  CG1 . ILE A 1 18  ? -46.393 14.955  -20.360 1.00 72.80  ?  18  ILE A CG1 1 
ATOM   80   C  CG2 . ILE A 1 18  ? -47.213 17.339  -20.562 1.00 73.68  ?  18  ILE A CG2 1 
ATOM   81   C  CD1 . ILE A 1 18  ? -44.936 15.220  -20.072 1.00 74.73  ?  18  ILE A CD1 1 
ATOM   82   N  N   . HIS A 1 19  ? -48.531 13.100  -22.267 1.00 72.09  ?  19  HIS A N   1 
ATOM   83   C  CA  . HIS A 1 19  ? -48.390 11.807  -22.992 1.00 74.38  ?  19  HIS A CA  1 
ATOM   84   C  C   . HIS A 1 19  ? -49.457 11.659  -24.091 1.00 75.52  ?  19  HIS A C   1 
ATOM   85   O  O   . HIS A 1 19  ? -49.221 10.861  -25.026 1.00 71.60  ?  19  HIS A O   1 
ATOM   86   C  CB  . HIS A 1 19  ? -48.413 10.635  -22.000 1.00 76.79  ?  19  HIS A CB  1 
ATOM   87   C  CG  . HIS A 1 19  ? -49.732 10.408  -21.339 1.00 79.01  ?  19  HIS A CG  1 
ATOM   88   N  ND1 . HIS A 1 19  ? -50.325 11.354  -20.524 1.00 80.07  ?  19  HIS A ND1 1 
ATOM   89   C  CD2 . HIS A 1 19  ? -50.563 9.344   -21.352 1.00 80.35  ?  19  HIS A CD2 1 
ATOM   90   C  CE1 . HIS A 1 19  ? -51.470 10.886  -20.073 1.00 80.89  ?  19  HIS A CE1 1 
ATOM   91   N  NE2 . HIS A 1 19  ? -51.641 9.655   -20.569 1.00 81.53  ?  19  HIS A NE2 1 
ATOM   92   N  N   . ILE A 1 20  ? -50.572 12.396  -23.994 1.00 76.42  ?  20  ILE A N   1 
ATOM   93   C  CA  . ILE A 1 20  ? -51.706 12.352  -24.971 1.00 77.65  ?  20  ILE A CA  1 
ATOM   94   C  C   . ILE A 1 20  ? -52.066 13.772  -25.415 1.00 76.65  ?  20  ILE A C   1 
ATOM   95   O  O   . ILE A 1 20  ? -53.157 14.261  -25.129 1.00 75.39  ?  20  ILE A O   1 
ATOM   96   C  CB  . ILE A 1 20  ? -52.916 11.608  -24.366 1.00 79.51  ?  20  ILE A CB  1 
ATOM   97   C  CG1 . ILE A 1 20  ? -53.277 12.132  -22.973 1.00 81.57  ?  20  ILE A CG1 1 
ATOM   98   C  CG2 . ILE A 1 20  ? -52.661 10.110  -24.347 1.00 80.11  ?  20  ILE A CG2 1 
ATOM   99   C  CD1 . ILE A 1 20  ? -54.692 11.823  -22.541 1.00 82.53  ?  20  ILE A CD1 1 
ATOM   100  N  N   . PRO A 1 21  ? -51.169 14.482  -26.136 1.00 76.01  ?  21  PRO A N   1 
ATOM   101  C  CA  . PRO A 1 21  ? -51.444 15.851  -26.572 1.00 77.12  ?  21  PRO A CA  1 
ATOM   102  C  C   . PRO A 1 21  ? -52.299 15.941  -27.846 1.00 77.52  ?  21  PRO A C   1 
ATOM   103  O  O   . PRO A 1 21  ? -52.827 17.001  -28.109 1.00 75.92  ?  21  PRO A O   1 
ATOM   104  C  CB  . PRO A 1 21  ? -50.033 16.394  -26.842 1.00 77.61  ?  21  PRO A CB  1 
ATOM   105  C  CG  . PRO A 1 21  ? -49.271 15.183  -27.344 1.00 77.38  ?  21  PRO A CG  1 
ATOM   106  C  CD  . PRO A 1 21  ? -49.844 14.010  -26.573 1.00 76.84  ?  21  PRO A CD  1 
ATOM   107  N  N   . GLY A 1 22  ? -52.395 14.844  -28.603 1.00 79.29  ?  22  GLY A N   1 
ATOM   108  C  CA  . GLY A 1 22  ? -53.116 14.782  -29.889 1.00 81.83  ?  22  GLY A CA  1 
ATOM   109  C  C   . GLY A 1 22  ? -52.496 15.681  -30.948 1.00 83.73  ?  22  GLY A C   1 
ATOM   110  O  O   . GLY A 1 22  ? -53.232 16.105  -31.855 1.00 90.55  ?  22  GLY A O   1 
ATOM   111  N  N   . TYR A 1 23  ? -51.193 15.963  -30.845 1.00 85.51  ?  23  TYR A N   1 
ATOM   112  C  CA  . TYR A 1 23  ? -50.405 16.759  -31.825 1.00 83.92  ?  23  TYR A CA  1 
ATOM   113  C  C   . TYR A 1 23  ? -49.001 16.159  -31.963 1.00 78.68  ?  23  TYR A C   1 
ATOM   114  O  O   . TYR A 1 23  ? -48.547 15.480  -31.025 1.00 78.00  ?  23  TYR A O   1 
ATOM   115  C  CB  . TYR A 1 23  ? -50.333 18.225  -31.391 1.00 88.29  ?  23  TYR A CB  1 
ATOM   116  C  CG  . TYR A 1 23  ? -51.603 19.011  -31.606 1.00 94.16  ?  23  TYR A CG  1 
ATOM   117  C  CD1 . TYR A 1 23  ? -52.628 18.988  -30.674 1.00 93.99  ?  23  TYR A CD1 1 
ATOM   118  C  CD2 . TYR A 1 23  ? -51.779 19.786  -32.742 1.00 97.43  ?  23  TYR A CD2 1 
ATOM   119  C  CE1 . TYR A 1 23  ? -53.797 19.707  -30.865 1.00 95.22  ?  23  TYR A CE1 1 
ATOM   120  C  CE2 . TYR A 1 23  ? -52.940 20.514  -32.948 1.00 98.61  ?  23  TYR A CE2 1 
ATOM   121  C  CZ  . TYR A 1 23  ? -53.954 20.474  -32.007 1.00 97.17  ?  23  TYR A CZ  1 
ATOM   122  O  OH  . TYR A 1 23  ? -55.097 21.190  -32.209 1.00 98.65  ?  23  TYR A OH  1 
ATOM   123  N  N   . ILE A 1 24  ? -48.346 16.395  -33.104 1.00 74.73  ?  24  ILE A N   1 
ATOM   124  C  CA  . ILE A 1 24  ? -46.916 16.029  -33.345 1.00 72.87  ?  24  ILE A CA  1 
ATOM   125  C  C   . ILE A 1 24  ? -46.158 17.248  -33.888 1.00 73.31  ?  24  ILE A C   1 
ATOM   126  O  O   . ILE A 1 24  ? -46.804 18.266  -34.199 1.00 74.06  ?  24  ILE A O   1 
ATOM   127  C  CB  . ILE A 1 24  ? -46.785 14.811  -34.281 1.00 69.48  ?  24  ILE A CB  1 
ATOM   128  C  CG1 . ILE A 1 24  ? -47.211 15.127  -35.717 1.00 70.44  ?  24  ILE A CG1 1 
ATOM   129  C  CG2 . ILE A 1 24  ? -47.535 13.617  -33.714 1.00 69.15  ?  24  ILE A CG2 1 
ATOM   130  C  CD1 . ILE A 1 24  ? -46.634 14.182  -36.747 1.00 71.27  ?  24  ILE A CD1 1 
ATOM   131  N  N   . GLN A 1 25  ? -44.833 17.129  -33.997 1.00 72.41  ?  25  GLN A N   1 
ATOM   132  C  CA  . GLN A 1 25  ? -43.927 18.214  -34.454 1.00 73.20  ?  25  GLN A CA  1 
ATOM   133  C  C   . GLN A 1 25  ? -43.813 18.158  -35.974 1.00 73.36  ?  25  GLN A C   1 
ATOM   134  O  O   . GLN A 1 25  ? -43.907 17.086  -36.570 1.00 71.05  ?  25  GLN A O   1 
ATOM   135  C  CB  . GLN A 1 25  ? -42.558 18.076  -33.787 1.00 75.94  ?  25  GLN A CB  1 
ATOM   136  C  CG  . GLN A 1 25  ? -42.611 18.174  -32.270 1.00 76.51  ?  25  GLN A CG  1 
ATOM   137  C  CD  . GLN A 1 25  ? -41.232 18.217  -31.656 1.00 76.19  ?  25  GLN A CD  1 
ATOM   138  O  OE1 . GLN A 1 25  ? -40.361 18.969  -32.092 1.00 73.45  ?  25  GLN A OE1 1 
ATOM   139  N  NE2 . GLN A 1 25  ? -41.026 17.411  -30.627 1.00 75.48  ?  25  GLN A NE2 1 
ATOM   140  N  N   . PRO A 1 26  ? -43.602 19.313  -36.644 1.00 72.25  ?  26  PRO A N   1 
ATOM   141  C  CA  . PRO A 1 26  ? -43.612 19.372  -38.106 1.00 73.69  ?  26  PRO A CA  1 
ATOM   142  C  C   . PRO A 1 26  ? -42.521 18.565  -38.829 1.00 72.17  ?  26  PRO A C   1 
ATOM   143  O  O   . PRO A 1 26  ? -42.740 18.233  -39.976 1.00 75.70  ?  26  PRO A O   1 
ATOM   144  C  CB  . PRO A 1 26  ? -43.422 20.867  -38.410 1.00 75.76  ?  26  PRO A CB  1 
ATOM   145  C  CG  . PRO A 1 26  ? -42.774 21.435  -37.164 1.00 75.89  ?  26  PRO A CG  1 
ATOM   146  C  CD  . PRO A 1 26  ? -43.352 20.624  -36.026 1.00 74.05  ?  26  PRO A CD  1 
ATOM   147  N  N   . HIS A 1 27  ? -41.403 18.254  -38.164 1.00 70.79  ?  27  HIS A N   1 
ATOM   148  C  CA  . HIS A 1 27  ? -40.183 17.677  -38.801 1.00 69.00  ?  27  HIS A CA  1 
ATOM   149  C  C   . HIS A 1 27  ? -40.407 16.214  -39.221 1.00 67.86  ?  27  HIS A C   1 
ATOM   150  O  O   . HIS A 1 27  ? -39.462 15.616  -39.774 1.00 72.72  ?  27  HIS A O   1 
ATOM   151  C  CB  . HIS A 1 27  ? -38.948 17.851  -37.897 1.00 68.65  ?  27  HIS A CB  1 
ATOM   152  C  CG  . HIS A 1 27  ? -38.921 16.979  -36.686 1.00 66.28  ?  27  HIS A CG  1 
ATOM   153  N  ND1 . HIS A 1 27  ? -39.414 17.398  -35.467 1.00 65.73  ?  27  HIS A ND1 1 
ATOM   154  C  CD2 . HIS A 1 27  ? -38.441 15.732  -36.493 1.00 66.81  ?  27  HIS A CD2 1 
ATOM   155  C  CE1 . HIS A 1 27  ? -39.256 16.438  -34.578 1.00 68.06  ?  27  HIS A CE1 1 
ATOM   156  N  NE2 . HIS A 1 27  ? -38.661 15.403  -35.183 1.00 67.17  ?  27  HIS A NE2 1 
ATOM   157  N  N   . GLY A 1 28  ? -41.599 15.660  -38.983 1.00 63.88  ?  28  GLY A N   1 
ATOM   158  C  CA  . GLY A 1 28  ? -41.970 14.306  -39.435 1.00 63.22  ?  28  GLY A CA  1 
ATOM   159  C  C   . GLY A 1 28  ? -43.474 14.117  -39.469 1.00 63.51  ?  28  GLY A C   1 
ATOM   160  O  O   . GLY A 1 28  ? -44.197 15.044  -39.059 1.00 63.05  ?  28  GLY A O   1 
ATOM   161  N  N   . CYS A 1 29  ? -43.924 12.958  -39.953 1.00 65.30  ?  29  CYS A N   1 
ATOM   162  C  CA  . CYS A 1 29  ? -45.362 12.560  -39.998 1.00 70.23  ?  29  CYS A CA  1 
ATOM   163  C  C   . CYS A 1 29  ? -45.529 11.189  -39.334 1.00 71.91  ?  29  CYS A C   1 
ATOM   164  O  O   . CYS A 1 29  ? -44.551 10.413  -39.312 1.00 71.84  ?  29  CYS A O   1 
ATOM   165  C  CB  . CYS A 1 29  ? -45.916 12.545  -41.420 1.00 71.40  ?  29  CYS A CB  1 
ATOM   166  S  SG  . CYS A 1 29  ? -45.308 11.170  -42.430 1.00 74.26  ?  29  CYS A SG  1 
ATOM   167  N  N   . LEU A 1 30  ? -46.729 10.921  -38.815 1.00 73.44  ?  30  LEU A N   1 
ATOM   168  C  CA  . LEU A 1 30  ? -47.031 9.755   -37.944 1.00 77.26  ?  30  LEU A CA  1 
ATOM   169  C  C   . LEU A 1 30  ? -48.250 9.010   -38.494 1.00 80.30  ?  30  LEU A C   1 
ATOM   170  O  O   . LEU A 1 30  ? -49.237 9.678   -38.862 1.00 83.81  ?  30  LEU A O   1 
ATOM   171  C  CB  . LEU A 1 30  ? -47.281 10.270  -36.523 1.00 78.51  ?  30  LEU A CB  1 
ATOM   172  C  CG  . LEU A 1 30  ? -47.564 9.207   -35.462 1.00 80.27  ?  30  LEU A CG  1 
ATOM   173  C  CD1 . LEU A 1 30  ? -47.037 9.650   -34.106 1.00 81.87  ?  30  LEU A CD1 1 
ATOM   174  C  CD2 . LEU A 1 30  ? -49.052 8.895   -35.372 1.00 82.02  ?  30  LEU A CD2 1 
ATOM   175  N  N   . ILE A 1 31  ? -48.171 7.678   -38.545 1.00 79.95  ?  31  ILE A N   1 
ATOM   176  C  CA  . ILE A 1 31  ? -49.311 6.776   -38.879 1.00 82.06  ?  31  ILE A CA  1 
ATOM   177  C  C   . ILE A 1 31  ? -49.461 5.766   -37.741 1.00 82.38  ?  31  ILE A C   1 
ATOM   178  O  O   . ILE A 1 31  ? -48.495 5.025   -37.486 1.00 82.73  ?  31  ILE A O   1 
ATOM   179  C  CB  . ILE A 1 31  ? -49.099 6.094   -40.247 1.00 85.32  ?  31  ILE A CB  1 
ATOM   180  C  CG1 . ILE A 1 31  ? -49.312 7.086   -41.394 1.00 86.98  ?  31  ILE A CG1 1 
ATOM   181  C  CG2 . ILE A 1 31  ? -49.983 4.861   -40.394 1.00 85.43  ?  31  ILE A CG2 1 
ATOM   182  C  CD1 . ILE A 1 31  ? -48.912 6.562   -42.754 1.00 88.22  ?  31  ILE A CD1 1 
ATOM   183  N  N   . ALA A 1 32  ? -50.624 5.759   -37.082 1.00 85.47  ?  32  ALA A N   1 
ATOM   184  C  CA  . ALA A 1 32  ? -51.019 4.753   -36.069 1.00 84.38  ?  32  ALA A CA  1 
ATOM   185  C  C   . ALA A 1 32  ? -51.846 3.660   -36.750 1.00 84.04  ?  32  ALA A C   1 
ATOM   186  O  O   . ALA A 1 32  ? -52.703 4.001   -37.590 1.00 84.06  ?  32  ALA A O   1 
ATOM   187  C  CB  . ALA A 1 32  ? -51.784 5.405   -34.947 1.00 84.51  ?  32  ALA A CB  1 
ATOM   188  N  N   . CYS A 1 33  ? -51.574 2.399   -36.408 1.00 84.70  ?  33  CYS A N   1 
ATOM   189  C  CA  . CYS A 1 33  ? -52.262 1.198   -36.956 1.00 84.91  ?  33  CYS A CA  1 
ATOM   190  C  C   . CYS A 1 33  ? -52.770 0.322   -35.809 1.00 84.57  ?  33  CYS A C   1 
ATOM   191  O  O   . CYS A 1 33  ? -52.451 0.623   -34.641 1.00 81.52  ?  33  CYS A O   1 
ATOM   192  C  CB  . CYS A 1 33  ? -51.328 0.388   -37.848 1.00 85.20  ?  33  CYS A CB  1 
ATOM   193  S  SG  . CYS A 1 33  ? -50.852 1.263   -39.360 1.00 89.61  ?  33  CYS A SG  1 
ATOM   194  N  N   . ASP A 1 34  ? -53.536 -0.719  -36.142 1.00 87.64  ?  34  ASP A N   1 
ATOM   195  C  CA  . ASP A 1 34  ? -54.026 -1.732  -35.169 1.00 89.01  ?  34  ASP A CA  1 
ATOM   196  C  C   . ASP A 1 34  ? -52.834 -2.562  -34.679 1.00 89.22  ?  34  ASP A C   1 
ATOM   197  O  O   . ASP A 1 34  ? -51.731 -2.429  -35.254 1.00 83.79  ?  34  ASP A O   1 
ATOM   198  C  CB  . ASP A 1 34  ? -55.133 -2.603  -35.772 1.00 89.47  ?  34  ASP A CB  1 
ATOM   199  C  CG  . ASP A 1 34  ? -54.690 -3.454  -36.950 1.00 90.03  ?  34  ASP A CG  1 
ATOM   200  O  OD1 . ASP A 1 34  ? -54.027 -4.489  -36.719 1.00 87.03  ?  34  ASP A OD1 1 
ATOM   201  O  OD2 . ASP A 1 34  ? -55.007 -3.069  -38.094 1.00 91.91  ?  34  ASP A OD2 1 
ATOM   202  N  N   . ASN A 1 35  ? -53.077 -3.405  -33.672 1.00 92.77  ?  35  ASN A N   1 
ATOM   203  C  CA  . ASN A 1 35  ? -52.060 -4.216  -32.947 1.00 95.41  ?  35  ASN A CA  1 
ATOM   204  C  C   . ASN A 1 35  ? -51.163 -4.981  -33.931 1.00 94.64  ?  35  ASN A C   1 
ATOM   205  O  O   . ASN A 1 35  ? -49.980 -5.162  -33.602 1.00 101.67 ?  35  ASN A O   1 
ATOM   206  C  CB  . ASN A 1 35  ? -52.727 -5.180  -31.961 1.00 100.34 ?  35  ASN A CB  1 
ATOM   207  C  CG  . ASN A 1 35  ? -51.759 -5.815  -30.984 1.00 104.25 ?  35  ASN A CG  1 
ATOM   208  O  OD1 . ASN A 1 35  ? -50.847 -5.159  -30.485 1.00 105.98 ?  35  ASN A OD1 1 
ATOM   209  N  ND2 . ASN A 1 35  ? -51.960 -7.090  -30.688 1.00 108.63 ?  35  ASN A ND2 1 
ATOM   210  N  N   . ALA A 1 36  ? -51.692 -5.418  -35.081 1.00 94.51  ?  36  ALA A N   1 
ATOM   211  C  CA  . ALA A 1 36  ? -50.987 -6.307  -36.040 1.00 96.67  ?  36  ALA A CA  1 
ATOM   212  C  C   . ALA A 1 36  ? -50.870 -5.666  -37.432 1.00 97.17  ?  36  ALA A C   1 
ATOM   213  O  O   . ALA A 1 36  ? -50.797 -6.422  -38.419 1.00 98.51  ?  36  ALA A O   1 
ATOM   214  C  CB  . ALA A 1 36  ? -51.695 -7.639  -36.102 1.00 96.66  ?  36  ALA A CB  1 
ATOM   215  N  N   . MET A 1 37  ? -50.823 -4.331  -37.509 1.00 99.19  ?  37  MET A N   1 
ATOM   216  C  CA  . MET A 1 37  ? -50.503 -3.562  -38.747 1.00 102.05 ?  37  MET A CA  1 
ATOM   217  C  C   . MET A 1 37  ? -51.341 -4.055  -39.935 1.00 101.70 ?  37  MET A C   1 
ATOM   218  O  O   . MET A 1 37  ? -50.746 -4.435  -40.967 1.00 98.20  ?  37  MET A O   1 
ATOM   219  C  CB  . MET A 1 37  ? -49.018 -3.697  -39.102 1.00 104.91 ?  37  MET A CB  1 
ATOM   220  C  CG  . MET A 1 37  ? -48.113 -2.793  -38.298 1.00 106.46 ?  37  MET A CG  1 
ATOM   221  S  SD  . MET A 1 37  ? -46.612 -2.352  -39.211 1.00 106.44 ?  37  MET A SD  1 
ATOM   222  C  CE  . MET A 1 37  ? -47.315 -1.358  -40.526 1.00 106.49 ?  37  MET A CE  1 
ATOM   223  N  N   . ARG A 1 38  ? -52.668 -4.048  -39.790 1.00 101.68 ?  38  ARG A N   1 
ATOM   224  C  CA  . ARG A 1 38  ? -53.626 -4.339  -40.897 1.00 99.62  ?  38  ARG A CA  1 
ATOM   225  C  C   . ARG A 1 38  ? -54.291 -3.035  -41.360 1.00 100.41 ?  38  ARG A C   1 
ATOM   226  O  O   . ARG A 1 38  ? -54.351 -2.808  -42.586 1.00 104.09 ?  38  ARG A O   1 
ATOM   227  C  CB  . ARG A 1 38  ? -54.669 -5.364  -40.437 1.00 96.38  ?  38  ARG A CB  1 
ATOM   228  N  N   . MET A 1 39  ? -54.746 -2.208  -40.415 1.00 99.05  ?  39  MET A N   1 
ATOM   229  C  CA  . MET A 1 39  ? -55.661 -1.060  -40.665 1.00 102.45 ?  39  MET A CA  1 
ATOM   230  C  C   . MET A 1 39  ? -55.046 0.233   -40.113 1.00 94.07  ?  39  MET A C   1 
ATOM   231  O  O   . MET A 1 39  ? -54.563 0.213   -38.966 1.00 95.68  ?  39  MET A O   1 
ATOM   232  C  CB  . MET A 1 39  ? -57.012 -1.314  -39.984 1.00 110.55 ?  39  MET A CB  1 
ATOM   233  C  CG  . MET A 1 39  ? -58.197 -0.697  -40.709 1.00 116.43 ?  39  MET A CG  1 
ATOM   234  S  SD  . MET A 1 39  ? -58.493 -1.429  -42.340 1.00 124.85 ?  39  MET A SD  1 
ATOM   235  C  CE  . MET A 1 39  ? -58.784 -3.143  -41.901 1.00 122.54 ?  39  MET A CE  1 
ATOM   236  N  N   . VAL A 1 40  ? -55.077 1.312   -40.902 1.00 84.66  ?  40  VAL A N   1 
ATOM   237  C  CA  . VAL A 1 40  ? -54.674 2.686   -40.478 1.00 81.84  ?  40  VAL A CA  1 
ATOM   238  C  C   . VAL A 1 40  ? -55.830 3.301   -39.683 1.00 83.17  ?  40  VAL A C   1 
ATOM   239  O  O   . VAL A 1 40  ? -56.858 3.635   -40.302 1.00 87.40  ?  40  VAL A O   1 
ATOM   240  C  CB  . VAL A 1 40  ? -54.290 3.564   -41.685 1.00 79.85  ?  40  VAL A CB  1 
ATOM   241  C  CG1 . VAL A 1 40  ? -54.167 5.036   -41.314 1.00 79.15  ?  40  VAL A CG1 1 
ATOM   242  C  CG2 . VAL A 1 40  ? -53.011 3.073   -42.342 1.00 78.84  ?  40  VAL A CG2 1 
ATOM   243  N  N   . LEU A 1 41  ? -55.654 3.449   -38.368 1.00 81.70  ?  41  LEU A N   1 
ATOM   244  C  CA  . LEU A 1 41  ? -56.687 3.970   -37.431 1.00 78.88  ?  41  LEU A CA  1 
ATOM   245  C  C   . LEU A 1 41  ? -56.534 5.487   -37.300 1.00 76.08  ?  41  LEU A C   1 
ATOM   246  O  O   . LEU A 1 41  ? -57.564 6.176   -37.198 1.00 75.91  ?  41  LEU A O   1 
ATOM   247  C  CB  . LEU A 1 41  ? -56.530 3.286   -36.070 1.00 79.57  ?  41  LEU A CB  1 
ATOM   248  C  CG  . LEU A 1 41  ? -56.334 1.772   -36.107 1.00 81.71  ?  41  LEU A CG  1 
ATOM   249  C  CD1 . LEU A 1 41  ? -56.418 1.188   -34.705 1.00 83.95  ?  41  LEU A CD1 1 
ATOM   250  C  CD2 . LEU A 1 41  ? -57.351 1.106   -37.025 1.00 80.77  ?  41  LEU A CD2 1 
ATOM   251  N  N   . ARG A 1 42  ? -55.289 5.967   -37.285 1.00 76.82  ?  42  ARG A N   1 
ATOM   252  C  CA  . ARG A 1 42  ? -54.946 7.404   -37.097 1.00 77.77  ?  42  ARG A CA  1 
ATOM   253  C  C   . ARG A 1 42  ? -53.752 7.779   -37.978 1.00 77.28  ?  42  ARG A C   1 
ATOM   254  O  O   . ARG A 1 42  ? -52.934 6.887   -38.292 1.00 75.23  ?  42  ARG A O   1 
ATOM   255  C  CB  . ARG A 1 42  ? -54.643 7.675   -35.621 1.00 78.12  ?  42  ARG A CB  1 
ATOM   256  C  CG  . ARG A 1 42  ? -55.883 7.796   -34.749 1.00 76.83  ?  42  ARG A CG  1 
ATOM   257  C  CD  . ARG A 1 42  ? -55.697 7.227   -33.359 1.00 76.35  ?  42  ARG A CD  1 
ATOM   258  N  NE  . ARG A 1 42  ? -56.473 7.969   -32.375 1.00 77.22  ?  42  ARG A NE  1 
ATOM   259  C  CZ  . ARG A 1 42  ? -56.840 7.510   -31.182 1.00 79.81  ?  42  ARG A CZ  1 
ATOM   260  N  NH1 . ARG A 1 42  ? -56.523 6.283   -30.799 1.00 77.21  ?  42  ARG A NH1 1 
ATOM   261  N  NH2 . ARG A 1 42  ? -57.538 8.289   -30.373 1.00 84.12  ?  42  ARG A NH2 1 
ATOM   262  N  N   . HIS A 1 43  ? -53.672 9.056   -38.357 1.00 77.40  ?  43  HIS A N   1 
ATOM   263  C  CA  . HIS A 1 43  ? -52.581 9.634   -39.187 1.00 81.59  ?  43  HIS A CA  1 
ATOM   264  C  C   . HIS A 1 43  ? -52.449 11.129  -38.879 1.00 81.11  ?  43  HIS A C   1 
ATOM   265  O  O   . HIS A 1 43  ? -53.458 11.745  -38.476 1.00 82.33  ?  43  HIS A O   1 
ATOM   266  C  CB  . HIS A 1 43  ? -52.840 9.364   -40.678 1.00 84.32  ?  43  HIS A CB  1 
ATOM   267  C  CG  . HIS A 1 43  ? -53.895 10.237  -41.272 1.00 87.07  ?  43  HIS A CG  1 
ATOM   268  N  ND1 . HIS A 1 43  ? -55.241 9.990   -41.097 1.00 86.84  ?  43  HIS A ND1 1 
ATOM   269  C  CD2 . HIS A 1 43  ? -53.810 11.358  -42.022 1.00 89.55  ?  43  HIS A CD2 1 
ATOM   270  C  CE1 . HIS A 1 43  ? -55.940 10.920  -41.717 1.00 89.36  ?  43  HIS A CE1 1 
ATOM   271  N  NE2 . HIS A 1 43  ? -55.086 11.771  -42.294 1.00 87.97  ?  43  HIS A NE2 1 
ATOM   272  N  N   . SER A 1 44  ? -51.245 11.679  -39.039 1.00 80.50  ?  44  SER A N   1 
ATOM   273  C  CA  . SER A 1 44  ? -50.973 13.137  -38.907 1.00 82.44  ?  44  SER A CA  1 
ATOM   274  C  C   . SER A 1 44  ? -51.468 13.852  -40.171 1.00 81.03  ?  44  SER A C   1 
ATOM   275  O  O   . SER A 1 44  ? -51.319 13.282  -41.266 1.00 80.86  ?  44  SER A O   1 
ATOM   276  C  CB  . SER A 1 44  ? -49.512 13.420  -38.630 1.00 82.87  ?  44  SER A CB  1 
ATOM   277  O  OG  . SER A 1 44  ? -48.667 12.743  -39.550 1.00 80.78  ?  44  SER A OG  1 
ATOM   278  N  N   . GLU A 1 45  ? -52.026 15.055  -40.015 1.00 81.48  ?  45  GLU A N   1 
ATOM   279  C  CA  . GLU A 1 45  ? -52.575 15.887  -41.124 1.00 86.59  ?  45  GLU A CA  1 
ATOM   280  C  C   . GLU A 1 45  ? -51.530 16.050  -42.239 1.00 84.99  ?  45  GLU A C   1 
ATOM   281  O  O   . GLU A 1 45  ? -51.940 16.164  -43.411 1.00 86.96  ?  45  GLU A O   1 
ATOM   282  C  CB  . GLU A 1 45  ? -53.023 17.246  -40.582 1.00 91.64  ?  45  GLU A CB  1 
ATOM   283  C  CG  . GLU A 1 45  ? -53.785 18.093  -41.585 1.00 95.88  ?  45  GLU A CG  1 
ATOM   284  C  CD  . GLU A 1 45  ? -54.347 19.378  -41.001 1.00 100.26 ?  45  GLU A CD  1 
ATOM   285  O  OE1 . GLU A 1 45  ? -53.838 20.462  -41.356 1.00 101.70 ?  45  GLU A OE1 1 
ATOM   286  O  OE2 . GLU A 1 45  ? -55.292 19.290  -40.190 1.00 101.52 ?  45  GLU A OE2 1 
ATOM   287  N  N   . ASN A 1 46  ? -50.237 16.056  -41.893 1.00 81.88  ?  46  ASN A N   1 
ATOM   288  C  CA  . ASN A 1 46  ? -49.117 16.316  -42.839 1.00 82.64  ?  46  ASN A CA  1 
ATOM   289  C  C   . ASN A 1 46  ? -48.650 15.013  -43.507 1.00 83.81  ?  46  ASN A C   1 
ATOM   290  O  O   . ASN A 1 46  ? -47.692 15.088  -44.305 1.00 81.95  ?  46  ASN A O   1 
ATOM   291  C  CB  . ASN A 1 46  ? -47.952 17.040  -42.155 1.00 83.27  ?  46  ASN A CB  1 
ATOM   292  C  CG  . ASN A 1 46  ? -47.120 16.158  -41.244 1.00 84.79  ?  46  ASN A CG  1 
ATOM   293  O  OD1 . ASN A 1 46  ? -47.608 15.165  -40.705 1.00 85.65  ?  46  ASN A OD1 1 
ATOM   294  N  ND2 . ASN A 1 46  ? -45.863 16.522  -41.051 1.00 84.29  ?  46  ASN A ND2 1 
ATOM   295  N  N   . CYS A 1 47  ? -49.278 13.869  -43.199 1.00 84.30  ?  47  CYS A N   1 
ATOM   296  C  CA  . CYS A 1 47  ? -48.949 12.552  -43.818 1.00 85.97  ?  47  CYS A CA  1 
ATOM   297  C  C   . CYS A 1 47  ? -48.959 12.677  -45.344 1.00 91.04  ?  47  CYS A C   1 
ATOM   298  O  O   . CYS A 1 47  ? -47.999 12.197  -45.977 1.00 92.42  ?  47  CYS A O   1 
ATOM   299  C  CB  . CYS A 1 47  ? -49.929 11.459  -43.412 1.00 86.00  ?  47  CYS A CB  1 
ATOM   300  S  SG  . CYS A 1 47  ? -49.387 10.513  -41.968 1.00 87.69  ?  47  CYS A SG  1 
ATOM   301  N  N   . GLY A 1 48  ? -50.014 13.289  -45.896 1.00 96.02  ?  48  GLY A N   1 
ATOM   302  C  CA  . GLY A 1 48  ? -50.182 13.531  -47.342 1.00 96.72  ?  48  GLY A CA  1 
ATOM   303  C  C   . GLY A 1 48  ? -49.042 14.354  -47.917 1.00 98.39  ?  48  GLY A C   1 
ATOM   304  O  O   . GLY A 1 48  ? -48.434 13.909  -48.911 1.00 98.23  ?  48  GLY A O   1 
ATOM   305  N  N   . GLU A 1 49  ? -48.748 15.502  -47.299 1.00 102.43 ?  49  GLU A N   1 
ATOM   306  C  CA  . GLU A 1 49  ? -47.745 16.495  -47.778 1.00 106.57 ?  49  GLU A CA  1 
ATOM   307  C  C   . GLU A 1 49  ? -46.368 15.836  -47.955 1.00 104.40 ?  49  GLU A C   1 
ATOM   308  O  O   . GLU A 1 49  ? -45.679 16.201  -48.926 1.00 102.96 ?  49  GLU A O   1 
ATOM   309  C  CB  . GLU A 1 49  ? -47.664 17.677  -46.809 1.00 110.07 ?  49  GLU A CB  1 
ATOM   310  C  CG  . GLU A 1 49  ? -46.654 18.735  -47.221 1.00 115.89 ?  49  GLU A CG  1 
ATOM   311  C  CD  . GLU A 1 49  ? -46.676 20.005  -46.385 1.00 121.99 ?  49  GLU A CD  1 
ATOM   312  O  OE1 . GLU A 1 49  ? -45.647 20.709  -46.360 1.00 123.40 ?  49  GLU A OE1 1 
ATOM   313  O  OE2 . GLU A 1 49  ? -47.722 20.290  -45.766 1.00 126.74 ?  49  GLU A OE2 1 
ATOM   314  N  N   . LEU A 1 50  ? -45.982 14.918  -47.059 1.00 102.05 ?  50  LEU A N   1 
ATOM   315  C  CA  . LEU A 1 50  ? -44.626 14.296  -47.028 1.00 103.44 ?  50  LEU A CA  1 
ATOM   316  C  C   . LEU A 1 50  ? -44.592 13.031  -47.895 1.00 105.01 ?  50  LEU A C   1 
ATOM   317  O  O   . LEU A 1 50  ? -43.622 12.874  -48.662 1.00 105.58 ?  50  LEU A O   1 
ATOM   318  C  CB  . LEU A 1 50  ? -44.234 13.964  -45.583 1.00 103.37 ?  50  LEU A CB  1 
ATOM   319  C  CG  . LEU A 1 50  ? -44.032 15.150  -44.638 1.00 103.24 ?  50  LEU A CG  1 
ATOM   320  C  CD1 . LEU A 1 50  ? -43.378 14.690  -43.344 1.00 103.53 ?  50  LEU A CD1 1 
ATOM   321  C  CD2 . LEU A 1 50  ? -43.197 16.252  -45.277 1.00 102.82 ?  50  LEU A CD2 1 
ATOM   322  N  N   . LEU A 1 51  ? -45.596 12.160  -47.759 1.00 107.20 ?  51  LEU A N   1 
ATOM   323  C  CA  . LEU A 1 51  ? -45.646 10.827  -48.422 1.00 108.47 ?  51  LEU A CA  1 
ATOM   324  C  C   . LEU A 1 51  ? -46.221 10.956  -49.840 1.00 111.61 ?  51  LEU A C   1 
ATOM   325  O  O   . LEU A 1 51  ? -46.048 10.005  -50.633 1.00 107.01 ?  51  LEU A O   1 
ATOM   326  C  CB  . LEU A 1 51  ? -46.488 9.877   -47.565 1.00 107.88 ?  51  LEU A CB  1 
ATOM   327  C  CG  . LEU A 1 51  ? -45.993 9.670   -46.133 1.00 108.11 ?  51  LEU A CG  1 
ATOM   328  C  CD1 . LEU A 1 51  ? -47.027 8.924   -45.301 1.00 108.79 ?  51  LEU A CD1 1 
ATOM   329  C  CD2 . LEU A 1 51  ? -44.664 8.930   -46.115 1.00 108.69 ?  51  LEU A CD2 1 
ATOM   330  N  N   . GLY A 1 52  ? -46.878 12.082  -50.142 1.00 115.96 ?  52  GLY A N   1 
ATOM   331  C  CA  . GLY A 1 52  ? -47.459 12.382  -51.467 1.00 119.66 ?  52  GLY A CA  1 
ATOM   332  C  C   . GLY A 1 52  ? -48.773 11.652  -51.690 1.00 121.51 ?  52  GLY A C   1 
ATOM   333  O  O   . GLY A 1 52  ? -49.010 11.204  -52.829 1.00 124.96 ?  52  GLY A O   1 
ATOM   334  N  N   . LEU A 1 53  ? -49.593 11.537  -50.638 1.00 121.42 ?  53  LEU A N   1 
ATOM   335  C  CA  . LEU A 1 53  ? -50.930 10.878  -50.657 1.00 122.25 ?  53  LEU A CA  1 
ATOM   336  C  C   . LEU A 1 53  ? -52.022 11.953  -50.601 1.00 123.27 ?  53  LEU A C   1 
ATOM   337  O  O   . LEU A 1 53  ? -51.747 13.047  -50.067 1.00 123.91 ?  53  LEU A O   1 
ATOM   338  C  CB  . LEU A 1 53  ? -51.032 9.914   -49.468 1.00 121.23 ?  53  LEU A CB  1 
ATOM   339  C  CG  . LEU A 1 53  ? -50.483 8.505   -49.697 1.00 120.83 ?  53  LEU A CG  1 
ATOM   340  C  CD1 . LEU A 1 53  ? -49.113 8.532   -50.359 1.00 120.53 ?  53  LEU A CD1 1 
ATOM   341  C  CD2 . LEU A 1 53  ? -50.420 7.732   -48.389 1.00 119.53 ?  53  LEU A CD2 1 
ATOM   342  N  N   . GLU A 1 54  ? -53.209 11.649  -51.137 1.00 125.65 ?  54  GLU A N   1 
ATOM   343  C  CA  . GLU A 1 54  ? -54.372 12.578  -51.193 1.00 124.32 ?  54  GLU A CA  1 
ATOM   344  C  C   . GLU A 1 54  ? -55.499 12.045  -50.299 1.00 120.95 ?  54  GLU A C   1 
ATOM   345  O  O   . GLU A 1 54  ? -55.640 10.807  -50.192 1.00 112.38 ?  54  GLU A O   1 
ATOM   346  C  CB  . GLU A 1 54  ? -54.850 12.753  -52.637 1.00 122.40 ?  54  GLU A CB  1 
ATOM   347  N  N   . GLY A 1 55  ? -56.253 12.956  -49.673 1.00 121.45 ?  55  GLY A N   1 
ATOM   348  C  CA  . GLY A 1 55  ? -57.465 12.651  -48.886 1.00 122.99 ?  55  GLY A CA  1 
ATOM   349  C  C   . GLY A 1 55  ? -57.146 12.029  -47.536 1.00 121.84 ?  55  GLY A C   1 
ATOM   350  O  O   . GLY A 1 55  ? -56.045 12.284  -47.007 1.00 120.55 ?  55  GLY A O   1 
ATOM   351  N  N   . ASP A 1 56  ? -58.087 11.242  -47.003 1.00 120.83 ?  56  ASP A N   1 
ATOM   352  C  CA  . ASP A 1 56  ? -58.026 10.609  -45.656 1.00 118.65 ?  56  ASP A CA  1 
ATOM   353  C  C   . ASP A 1 56  ? -57.411 9.208   -45.788 1.00 116.57 ?  56  ASP A C   1 
ATOM   354  O  O   . ASP A 1 56  ? -57.737 8.505   -46.770 1.00 109.17 ?  56  ASP A O   1 
ATOM   355  C  CB  . ASP A 1 56  ? -59.418 10.582  -45.014 1.00 119.04 ?  56  ASP A CB  1 
ATOM   356  C  CG  . ASP A 1 56  ? -59.446 10.068  -43.584 1.00 118.57 ?  56  ASP A CG  1 
ATOM   357  O  OD1 . ASP A 1 56  ? -59.220 8.859   -43.396 1.00 117.85 ?  56  ASP A OD1 1 
ATOM   358  O  OD2 . ASP A 1 56  ? -59.700 10.881  -42.671 1.00 114.30 ?  56  ASP A OD2 1 
ATOM   359  N  N   . LEU A 1 57  ? -56.551 8.834   -44.833 1.00 115.39 ?  57  LEU A N   1 
ATOM   360  C  CA  . LEU A 1 57  ? -55.828 7.531   -44.788 1.00 113.75 ?  57  LEU A CA  1 
ATOM   361  C  C   . LEU A 1 57  ? -56.516 6.575   -43.803 1.00 110.44 ?  57  LEU A C   1 
ATOM   362  O  O   . LEU A 1 57  ? -56.235 5.361   -43.870 1.00 103.81 ?  57  LEU A O   1 
ATOM   363  C  CB  . LEU A 1 57  ? -54.371 7.774   -44.379 1.00 115.87 ?  57  LEU A CB  1 
ATOM   364  C  CG  . LEU A 1 57  ? -53.447 8.297   -45.480 1.00 118.26 ?  57  LEU A CG  1 
ATOM   365  C  CD1 . LEU A 1 57  ? -53.681 9.778   -45.739 1.00 118.29 ?  57  LEU A CD1 1 
ATOM   366  C  CD2 . LEU A 1 57  ? -51.989 8.045   -45.126 1.00 119.00 ?  57  LEU A CD2 1 
ATOM   367  N  N   . ASN A 1 58  ? -57.368 7.100   -42.916 1.00 108.96 ?  58  ASN A N   1 
ATOM   368  C  CA  . ASN A 1 58  ? -58.041 6.320   -41.842 1.00 107.92 ?  58  ASN A CA  1 
ATOM   369  C  C   . ASN A 1 58  ? -59.142 5.450   -42.457 1.00 105.69 ?  58  ASN A C   1 
ATOM   370  O  O   . ASN A 1 58  ? -59.953 5.985   -43.238 1.00 104.92 ?  58  ASN A O   1 
ATOM   371  C  CB  . ASN A 1 58  ? -58.591 7.227   -40.739 1.00 106.70 ?  58  ASN A CB  1 
ATOM   372  C  CG  . ASN A 1 58  ? -57.496 7.955   -39.989 1.00 106.40 ?  58  ASN A CG  1 
ATOM   373  O  OD1 . ASN A 1 58  ? -56.372 7.466   -39.890 1.00 103.92 ?  58  ASN A OD1 1 
ATOM   374  N  ND2 . ASN A 1 58  ? -57.813 9.123   -39.456 1.00 107.00 ?  58  ASN A ND2 1 
ATOM   375  N  N   . GLY A 1 59  ? -59.158 4.161   -42.101 1.00 103.92 ?  59  GLY A N   1 
ATOM   376  C  CA  . GLY A 1 59  ? -60.078 3.152   -42.659 1.00 106.75 ?  59  GLY A CA  1 
ATOM   377  C  C   . GLY A 1 59  ? -59.404 2.335   -43.747 1.00 107.79 ?  59  GLY A C   1 
ATOM   378  O  O   . GLY A 1 59  ? -59.681 1.123   -43.827 1.00 106.93 ?  59  GLY A O   1 
ATOM   379  N  N   . ARG A 1 60  ? -58.552 2.976   -44.558 1.00 109.54 ?  60  ARG A N   1 
ATOM   380  C  CA  . ARG A 1 60  ? -57.765 2.307   -45.634 1.00 111.80 ?  60  ARG A CA  1 
ATOM   381  C  C   . ARG A 1 60  ? -56.745 1.362   -44.989 1.00 111.91 ?  60  ARG A C   1 
ATOM   382  O  O   . ARG A 1 60  ? -56.311 1.650   -43.857 1.00 113.53 ?  60  ARG A O   1 
ATOM   383  C  CB  . ARG A 1 60  ? -57.105 3.354   -46.537 1.00 110.73 ?  60  ARG A CB  1 
ATOM   384  C  CG  . ARG A 1 60  ? -58.101 4.243   -47.271 1.00 112.69 ?  60  ARG A CG  1 
ATOM   385  C  CD  . ARG A 1 60  ? -57.477 5.482   -47.880 1.00 113.40 ?  60  ARG A CD  1 
ATOM   386  N  NE  . ARG A 1 60  ? -56.503 5.167   -48.916 1.00 114.72 ?  60  ARG A NE  1 
ATOM   387  C  CZ  . ARG A 1 60  ? -55.863 6.067   -49.659 1.00 115.30 ?  60  ARG A CZ  1 
ATOM   388  N  NH1 . ARG A 1 60  ? -54.993 5.667   -50.571 1.00 113.86 ?  60  ARG A NH1 1 
ATOM   389  N  NH2 . ARG A 1 60  ? -56.092 7.360   -49.492 1.00 117.38 ?  60  ARG A NH2 1 
ATOM   390  N  N   . THR A 1 61  ? -56.396 0.270   -45.678 1.00 113.11 ?  61  THR A N   1 
ATOM   391  C  CA  . THR A 1 61  ? -55.525 -0.816  -45.142 1.00 114.48 ?  61  THR A CA  1 
ATOM   392  C  C   . THR A 1 61  ? -54.057 -0.384  -45.229 1.00 114.15 ?  61  THR A C   1 
ATOM   393  O  O   . THR A 1 61  ? -53.749 0.515   -46.041 1.00 111.07 ?  61  THR A O   1 
ATOM   394  C  CB  . THR A 1 61  ? -55.764 -2.143  -45.874 1.00 116.47 ?  61  THR A CB  1 
ATOM   395  O  OG1 . THR A 1 61  ? -55.409 -1.966  -47.246 1.00 120.70 ?  61  THR A OG1 1 
ATOM   396  C  CG2 . THR A 1 61  ? -57.197 -2.619  -45.773 1.00 117.73 ?  61  THR A CG2 1 
ATOM   397  N  N   . ALA A 1 62  ? -53.200 -1.010  -44.416 1.00 112.17 ?  62  ALA A N   1 
ATOM   398  C  CA  . ALA A 1 62  ? -51.752 -0.712  -44.291 1.00 110.85 ?  62  ALA A CA  1 
ATOM   399  C  C   . ALA A 1 62  ? -51.073 -0.813  -45.661 1.00 113.97 ?  62  ALA A C   1 
ATOM   400  O  O   . ALA A 1 62  ? -50.258 0.073   -45.984 1.00 116.59 ?  62  ALA A O   1 
ATOM   401  C  CB  . ALA A 1 62  ? -51.114 -1.652  -43.298 1.00 109.89 ?  62  ALA A CB  1 
ATOM   402  N  N   . GLU A 1 63  ? -51.415 -1.849  -46.433 1.00 118.44 ?  63  GLU A N   1 
ATOM   403  C  CA  . GLU A 1 63  ? -50.754 -2.194  -47.723 1.00 118.50 ?  63  GLU A CA  1 
ATOM   404  C  C   . GLU A 1 63  ? -51.210 -1.218  -48.817 1.00 114.85 ?  63  GLU A C   1 
ATOM   405  O  O   . GLU A 1 63  ? -50.432 -0.997  -49.765 1.00 111.56 ?  63  GLU A O   1 
ATOM   406  C  CB  . GLU A 1 63  ? -51.048 -3.650  -48.094 1.00 120.04 ?  63  GLU A CB  1 
ATOM   407  C  CG  . GLU A 1 63  ? -50.803 -4.618  -46.945 1.00 121.44 ?  63  GLU A CG  1 
ATOM   408  C  CD  . GLU A 1 63  ? -50.547 -6.068  -47.324 1.00 122.02 ?  63  GLU A CD  1 
ATOM   409  O  OE1 . GLU A 1 63  ? -50.580 -6.389  -48.529 1.00 123.39 ?  63  GLU A OE1 1 
ATOM   410  O  OE2 . GLU A 1 63  ? -50.312 -6.876  -46.403 1.00 118.76 ?  63  GLU A OE2 1 
ATOM   411  N  N   . ASP A 1 64  ? -52.410 -0.646  -48.675 1.00 112.47 ?  64  ASP A N   1 
ATOM   412  C  CA  . ASP A 1 64  ? -53.015 0.300   -49.652 1.00 113.87 ?  64  ASP A CA  1 
ATOM   413  C  C   . ASP A 1 64  ? -52.258 1.636   -49.628 1.00 116.73 ?  64  ASP A C   1 
ATOM   414  O  O   . ASP A 1 64  ? -52.157 2.262   -50.699 1.00 121.42 ?  64  ASP A O   1 
ATOM   415  C  CB  . ASP A 1 64  ? -54.506 0.508   -49.373 1.00 109.81 ?  64  ASP A CB  1 
ATOM   416  N  N   . VAL A 1 65  ? -51.737 2.046   -48.464 1.00 119.62 ?  65  VAL A N   1 
ATOM   417  C  CA  . VAL A 1 65  ? -51.195 3.422   -48.223 1.00 118.69 ?  65  VAL A CA  1 
ATOM   418  C  C   . VAL A 1 65  ? -49.662 3.420   -48.334 1.00 114.65 ?  65  VAL A C   1 
ATOM   419  O  O   . VAL A 1 65  ? -49.122 4.363   -48.945 1.00 112.90 ?  65  VAL A O   1 
ATOM   420  C  CB  . VAL A 1 65  ? -51.661 4.008   -46.873 1.00 119.56 ?  65  VAL A CB  1 
ATOM   421  C  CG1 . VAL A 1 65  ? -53.140 4.362   -46.892 1.00 119.69 ?  65  VAL A CG1 1 
ATOM   422  C  CG2 . VAL A 1 65  ? -51.349 3.097   -45.696 1.00 120.40 ?  65  VAL A CG2 1 
ATOM   423  N  N   . LEU A 1 66  ? -48.992 2.414   -47.763 1.00 112.96 ?  66  LEU A N   1 
ATOM   424  C  CA  . LEU A 1 66  ? -47.505 2.324   -47.708 1.00 113.30 ?  66  LEU A CA  1 
ATOM   425  C  C   . LEU A 1 66  ? -46.992 1.477   -48.877 1.00 112.42 ?  66  LEU A C   1 
ATOM   426  O  O   . LEU A 1 66  ? -46.034 1.918   -49.546 1.00 112.14 ?  66  LEU A O   1 
ATOM   427  C  CB  . LEU A 1 66  ? -47.079 1.715   -46.368 1.00 112.16 ?  66  LEU A CB  1 
ATOM   428  C  CG  . LEU A 1 66  ? -47.544 2.461   -45.117 1.00 108.15 ?  66  LEU A CG  1 
ATOM   429  C  CD1 . LEU A 1 66  ? -47.018 1.782   -43.862 1.00 109.17 ?  66  LEU A CD1 1 
ATOM   430  C  CD2 . LEU A 1 66  ? -47.117 3.921   -45.148 1.00 105.92 ?  66  LEU A CD2 1 
ATOM   431  N  N   . GLY A 1 67  ? -47.604 0.308   -49.093 1.00 112.29 ?  67  GLY A N   1 
ATOM   432  C  CA  . GLY A 1 67  ? -47.227 -0.661  -50.141 1.00 113.88 ?  67  GLY A CA  1 
ATOM   433  C  C   . GLY A 1 67  ? -46.804 -1.987  -49.536 1.00 113.74 ?  67  GLY A C   1 
ATOM   434  O  O   . GLY A 1 67  ? -46.079 -1.960  -48.524 1.00 115.30 ?  67  GLY A O   1 
ATOM   435  N  N   . LYS A 1 68  ? -47.229 -3.100  -50.144 1.00 115.64 ?  68  LYS A N   1 
ATOM   436  C  CA  . LYS A 1 68  ? -46.994 -4.493  -49.665 1.00 116.98 ?  68  LYS A CA  1 
ATOM   437  C  C   . LYS A 1 68  ? -45.508 -4.707  -49.346 1.00 118.88 ?  68  LYS A C   1 
ATOM   438  O  O   . LYS A 1 68  ? -45.217 -5.442  -48.379 1.00 115.55 ?  68  LYS A O   1 
ATOM   439  C  CB  . LYS A 1 68  ? -47.463 -5.506  -50.716 1.00 114.82 ?  68  LYS A CB  1 
ATOM   440  N  N   . ARG A 1 69  ? -44.615 -4.097  -50.135 1.00 123.29 ?  69  ARG A N   1 
ATOM   441  C  CA  . ARG A 1 69  ? -43.133 -4.199  -49.989 1.00 123.22 ?  69  ARG A CA  1 
ATOM   442  C  C   . ARG A 1 69  ? -42.710 -3.745  -48.585 1.00 122.41 ?  69  ARG A C   1 
ATOM   443  O  O   . ARG A 1 69  ? -42.099 -4.557  -47.858 1.00 119.71 ?  69  ARG A O   1 
ATOM   444  C  CB  . ARG A 1 69  ? -42.432 -3.359  -51.064 1.00 120.86 ?  69  ARG A CB  1 
ATOM   445  N  N   . LEU A 1 70  ? -43.040 -2.499  -48.226 1.00 119.74 ?  70  LEU A N   1 
ATOM   446  C  CA  . LEU A 1 70  ? -42.607 -1.821  -46.970 1.00 115.57 ?  70  LEU A CA  1 
ATOM   447  C  C   . LEU A 1 70  ? -43.300 -2.447  -45.750 1.00 113.50 ?  70  LEU A C   1 
ATOM   448  O  O   . LEU A 1 70  ? -42.612 -2.671  -44.737 1.00 112.17 ?  70  LEU A O   1 
ATOM   449  C  CB  . LEU A 1 70  ? -42.925 -0.324  -47.079 1.00 113.08 ?  70  LEU A CB  1 
ATOM   450  C  CG  . LEU A 1 70  ? -42.530 0.538   -45.879 1.00 110.27 ?  70  LEU A CG  1 
ATOM   451  C  CD1 . LEU A 1 70  ? -41.056 0.372   -45.536 1.00 108.50 ?  70  LEU A CD1 1 
ATOM   452  C  CD2 . LEU A 1 70  ? -42.853 2.002   -46.140 1.00 110.07 ?  70  LEU A CD2 1 
ATOM   453  N  N   . VAL A 1 71  ? -44.607 -2.714  -45.848 1.00 111.27 ?  71  VAL A N   1 
ATOM   454  C  CA  . VAL A 1 71  ? -45.460 -3.227  -44.729 1.00 111.88 ?  71  VAL A CA  1 
ATOM   455  C  C   . VAL A 1 71  ? -44.903 -4.570  -44.235 1.00 111.67 ?  71  VAL A C   1 
ATOM   456  O  O   . VAL A 1 71  ? -45.016 -4.845  -43.023 1.00 106.59 ?  71  VAL A O   1 
ATOM   457  C  CB  . VAL A 1 71  ? -46.937 -3.341  -45.160 1.00 112.86 ?  71  VAL A CB  1 
ATOM   458  C  CG1 . VAL A 1 71  ? -47.782 -4.095  -44.141 1.00 113.35 ?  71  VAL A CG1 1 
ATOM   459  C  CG2 . VAL A 1 71  ? -47.545 -1.974  -45.438 1.00 113.28 ?  71  VAL A CG2 1 
ATOM   460  N  N   . HIS A 1 72  ? -44.322 -5.370  -45.135 1.00 116.35 ?  72  HIS A N   1 
ATOM   461  C  CA  . HIS A 1 72  ? -43.719 -6.697  -44.829 1.00 118.29 ?  72  HIS A CA  1 
ATOM   462  C  C   . HIS A 1 72  ? -42.477 -6.507  -43.946 1.00 115.41 ?  72  HIS A C   1 
ATOM   463  O  O   . HIS A 1 72  ? -42.349 -7.241  -42.941 1.00 109.28 ?  72  HIS A O   1 
ATOM   464  C  CB  . HIS A 1 72  ? -43.405 -7.457  -46.125 1.00 125.02 ?  72  HIS A CB  1 
ATOM   465  C  CG  . HIS A 1 72  ? -43.177 -8.919  -45.927 1.00 132.88 ?  72  HIS A CG  1 
ATOM   466  N  ND1 . HIS A 1 72  ? -41.919 -9.489  -46.007 1.00 136.00 ?  72  HIS A ND1 1 
ATOM   467  C  CD2 . HIS A 1 72  ? -44.033 -9.927  -45.649 1.00 136.12 ?  72  HIS A CD2 1 
ATOM   468  C  CE1 . HIS A 1 72  ? -42.011 -10.785 -45.789 1.00 136.94 ?  72  HIS A CE1 1 
ATOM   469  N  NE2 . HIS A 1 72  ? -43.299 -11.079 -45.566 1.00 139.61 ?  72  HIS A NE2 1 
ATOM   470  N  N   . ASP A 1 73  ? -41.609 -5.555  -44.312 1.00 114.63 ?  73  ASP A N   1 
ATOM   471  C  CA  . ASP A 1 73  ? -40.360 -5.209  -43.576 1.00 113.83 ?  73  ASP A CA  1 
ATOM   472  C  C   . ASP A 1 73  ? -40.708 -4.743  -42.155 1.00 109.08 ?  73  ASP A C   1 
ATOM   473  O  O   . ASP A 1 73  ? -40.032 -5.195  -41.208 1.00 107.98 ?  73  ASP A O   1 
ATOM   474  C  CB  . ASP A 1 73  ? -39.549 -4.137  -44.314 1.00 115.15 ?  73  ASP A CB  1 
ATOM   475  C  CG  . ASP A 1 73  ? -38.866 -4.622  -45.584 1.00 113.88 ?  73  ASP A CG  1 
ATOM   476  O  OD1 . ASP A 1 73  ? -38.086 -5.591  -45.497 1.00 109.81 ?  73  ASP A OD1 1 
ATOM   477  O  OD2 . ASP A 1 73  ? -39.114 -4.021  -46.650 1.00 112.20 ?  73  ASP A OD2 1 
ATOM   478  N  N   . LEU A 1 74  ? -41.722 -3.880  -42.020 1.00 104.76 ?  74  LEU A N   1 
ATOM   479  C  CA  . LEU A 1 74  ? -42.148 -3.263  -40.731 1.00 101.88 ?  74  LEU A CA  1 
ATOM   480  C  C   . LEU A 1 74  ? -42.694 -4.335  -39.779 1.00 101.25 ?  74  LEU A C   1 
ATOM   481  O  O   . LEU A 1 74  ? -42.341 -4.288  -38.586 1.00 97.49  ?  74  LEU A O   1 
ATOM   482  C  CB  . LEU A 1 74  ? -43.203 -2.184  -40.998 1.00 100.31 ?  74  LEU A CB  1 
ATOM   483  C  CG  . LEU A 1 74  ? -42.718 -0.942  -41.745 1.00 98.42  ?  74  LEU A CG  1 
ATOM   484  C  CD1 . LEU A 1 74  ? -43.869 0.023   -41.985 1.00 96.03  ?  74  LEU A CD1 1 
ATOM   485  C  CD2 . LEU A 1 74  ? -41.592 -0.244  -40.996 1.00 98.05  ?  74  LEU A CD2 1 
ATOM   486  N  N   . ARG A 1 75  ? -43.524 -5.259  -40.279 1.00 105.44 ?  75  ARG A N   1 
ATOM   487  C  CA  . ARG A 1 75  ? -44.113 -6.356  -39.454 1.00 109.79 ?  75  ARG A CA  1 
ATOM   488  C  C   . ARG A 1 75  ? -42.987 -7.241  -38.902 1.00 109.27 ?  75  ARG A C   1 
ATOM   489  O  O   . ARG A 1 75  ? -42.992 -7.506  -37.681 1.00 105.53 ?  75  ARG A O   1 
ATOM   490  C  CB  . ARG A 1 75  ? -45.103 -7.197  -40.268 1.00 113.12 ?  75  ARG A CB  1 
ATOM   491  C  CG  . ARG A 1 75  ? -46.518 -6.638  -40.323 1.00 113.82 ?  75  ARG A CG  1 
ATOM   492  C  CD  . ARG A 1 75  ? -47.545 -7.726  -40.592 1.00 114.82 ?  75  ARG A CD  1 
ATOM   493  N  NE  . ARG A 1 75  ? -48.855 -7.204  -40.972 1.00 115.29 ?  75  ARG A NE  1 
ATOM   494  C  CZ  . ARG A 1 75  ? -49.353 -7.177  -42.210 1.00 115.08 ?  75  ARG A CZ  1 
ATOM   495  N  NH1 . ARG A 1 75  ? -48.661 -7.645  -43.235 1.00 116.26 ?  75  ARG A NH1 1 
ATOM   496  N  NH2 . ARG A 1 75  ? -50.559 -6.677  -42.419 1.00 115.93 ?  75  ARG A NH2 1 
ATOM   497  N  N   . ASN A 1 76  ? -42.060 -7.669  -39.769 1.00 110.39 ?  76  ASN A N   1 
ATOM   498  C  CA  . ASN A 1 76  ? -40.922 -8.570  -39.427 1.00 111.84 ?  76  ASN A CA  1 
ATOM   499  C  C   . ASN A 1 76  ? -40.015 -7.900  -38.385 1.00 111.51 ?  76  ASN A C   1 
ATOM   500  O  O   . ASN A 1 76  ? -39.413 -8.633  -37.576 1.00 110.14 ?  76  ASN A O   1 
ATOM   501  C  CB  . ASN A 1 76  ? -40.126 -8.977  -40.670 1.00 108.38 ?  76  ASN A CB  1 
ATOM   502  N  N   . ALA A 1 77  ? -39.929 -6.565  -38.403 1.00 114.25 ?  77  ALA A N   1 
ATOM   503  C  CA  . ALA A 1 77  ? -39.084 -5.748  -37.496 1.00 115.90 ?  77  ALA A CA  1 
ATOM   504  C  C   . ALA A 1 77  ? -39.665 -5.737  -36.074 1.00 117.09 ?  77  ALA A C   1 
ATOM   505  O  O   . ALA A 1 77  ? -38.875 -5.883  -35.121 1.00 116.84 ?  77  ALA A O   1 
ATOM   506  C  CB  . ALA A 1 77  ? -38.943 -4.348  -38.043 1.00 115.64 ?  77  ALA A CB  1 
ATOM   507  N  N   . LEU A 1 78  ? -40.985 -5.559  -35.937 1.00 119.19 ?  78  LEU A N   1 
ATOM   508  C  CA  . LEU A 1 78  ? -41.690 -5.459  -34.625 1.00 120.29 ?  78  LEU A CA  1 
ATOM   509  C  C   . LEU A 1 78  ? -41.691 -6.830  -33.935 1.00 126.02 ?  78  LEU A C   1 
ATOM   510  O  O   . LEU A 1 78  ? -42.741 -7.505  -33.967 1.00 126.97 ?  78  LEU A O   1 
ATOM   511  C  CB  . LEU A 1 78  ? -43.117 -4.949  -34.854 1.00 115.14 ?  78  LEU A CB  1 
ATOM   512  N  N   . THR A 1 79  ? -40.558 -7.213  -33.332 1.00 134.32 ?  79  THR A N   1 
ATOM   513  C  CA  . THR A 1 79  ? -40.347 -8.528  -32.653 1.00 135.34 ?  79  THR A CA  1 
ATOM   514  C  C   . THR A 1 79  ? -39.518 -8.316  -31.378 1.00 135.43 ?  79  THR A C   1 
ATOM   515  O  O   . THR A 1 79  ? -38.360 -7.872  -31.516 1.00 135.54 ?  79  THR A O   1 
ATOM   516  C  CB  . THR A 1 79  ? -39.703 -9.560  -33.592 1.00 133.47 ?  79  THR A CB  1 
ATOM   517  O  OG1 . THR A 1 79  ? -38.467 -9.028  -34.071 1.00 129.83 ?  79  THR A OG1 1 
ATOM   518  C  CG2 . THR A 1 79  ? -40.591 -9.932  -34.761 1.00 130.56 ?  79  THR A CG2 1 
ATOM   519  N  N   . THR A 1 84  ? -41.651 -6.231  -26.179 1.00 136.53 ?  84  THR A N   1 
ATOM   520  C  CA  . THR A 1 84  ? -40.773 -5.067  -25.871 1.00 135.41 ?  84  THR A CA  1 
ATOM   521  C  C   . THR A 1 84  ? -41.455 -3.778  -26.349 1.00 129.95 ?  84  THR A C   1 
ATOM   522  O  O   . THR A 1 84  ? -42.140 -3.826  -27.393 1.00 129.19 ?  84  THR A O   1 
ATOM   523  C  CB  . THR A 1 84  ? -39.371 -5.252  -26.473 1.00 139.43 ?  84  THR A CB  1 
ATOM   524  O  OG1 . THR A 1 84  ? -38.548 -4.173  -26.027 1.00 139.67 ?  84  THR A OG1 1 
ATOM   525  C  CG2 . THR A 1 84  ? -39.355 -5.302  -27.986 1.00 139.99 ?  84  THR A CG2 1 
ATOM   526  N  N   . THR A 1 85  ? -41.277 -2.679  -25.606 0.89 122.85 ?  85  THR A N   1 
ATOM   527  C  CA  . THR A 1 85  ? -41.859 -1.338  -25.911 0.89 117.61 ?  85  THR A CA  1 
ATOM   528  C  C   . THR A 1 85  ? -40.763 -0.402  -26.441 0.89 111.11 ?  85  THR A C   1 
ATOM   529  O  O   . THR A 1 85  ? -41.090 0.760   -26.755 0.89 104.05 ?  85  THR A O   1 
ATOM   530  C  CB  . THR A 1 85  ? -42.557 -0.748  -24.679 0.89 116.78 ?  85  THR A CB  1 
ATOM   531  O  OG1 . THR A 1 85  ? -43.225 -1.809  -23.994 0.89 117.10 ?  85  THR A OG1 1 
ATOM   532  C  CG2 . THR A 1 85  ? -43.559 0.334   -25.019 0.89 115.17 ?  85  THR A CG2 1 
ATOM   533  N  N   . ARG A 1 86  ? -39.523 -0.894  -26.552 1.00 109.29 ?  86  ARG A N   1 
ATOM   534  C  CA  . ARG A 1 86  ? -38.362 -0.132  -27.098 1.00 106.37 ?  86  ARG A CA  1 
ATOM   535  C  C   . ARG A 1 86  ? -38.569 0.072   -28.600 1.00 102.18 ?  86  ARG A C   1 
ATOM   536  O  O   . ARG A 1 86  ? -38.634 -0.903  -29.347 1.00 99.36  ?  86  ARG A O   1 
ATOM   537  C  CB  . ARG A 1 86  ? -37.053 -0.878  -26.816 1.00 102.67 ?  86  ARG A CB  1 
ATOM   538  N  N   . PRO A 1 87  ? -38.688 1.330   -29.094 1.00 97.20  ?  87  PRO A N   1 
ATOM   539  C  CA  . PRO A 1 87  ? -38.872 1.587   -30.525 1.00 95.20  ?  87  PRO A CA  1 
ATOM   540  C  C   . PRO A 1 87  ? -37.747 1.039   -31.416 1.00 94.05  ?  87  PRO A C   1 
ATOM   541  O  O   . PRO A 1 87  ? -36.589 1.215   -31.077 1.00 96.49  ?  87  PRO A O   1 
ATOM   542  C  CB  . PRO A 1 87  ? -38.891 3.120   -30.640 1.00 93.72  ?  87  PRO A CB  1 
ATOM   543  C  CG  . PRO A 1 87  ? -39.254 3.600   -29.251 1.00 94.99  ?  87  PRO A CG  1 
ATOM   544  C  CD  . PRO A 1 87  ? -38.664 2.573   -28.306 1.00 95.01  ?  87  PRO A CD  1 
ATOM   545  N  N   . ALA A 1 88  ? -38.121 0.404   -32.530 1.00 91.35  ?  88  ALA A N   1 
ATOM   546  C  CA  . ALA A 1 88  ? -37.201 -0.098  -33.577 1.00 90.44  ?  88  ALA A CA  1 
ATOM   547  C  C   . ALA A 1 88  ? -36.883 1.035   -34.560 1.00 91.33  ?  88  ALA A C   1 
ATOM   548  O  O   . ALA A 1 88  ? -37.828 1.564   -35.178 1.00 87.66  ?  88  ALA A O   1 
ATOM   549  C  CB  . ALA A 1 88  ? -37.812 -1.282  -34.283 1.00 90.67  ?  88  ALA A CB  1 
ATOM   550  N  N   . MET A 1 89  ? -35.600 1.389   -34.679 1.00 93.29  ?  89  MET A N   1 
ATOM   551  C  CA  . MET A 1 89  ? -35.076 2.412   -35.623 1.00 94.70  ?  89  MET A CA  1 
ATOM   552  C  C   . MET A 1 89  ? -34.725 1.723   -36.945 1.00 98.88  ?  89  MET A C   1 
ATOM   553  O  O   . MET A 1 89  ? -34.020 0.699   -36.894 1.00 102.82 ?  89  MET A O   1 
ATOM   554  C  CB  . MET A 1 89  ? -33.819 3.079   -35.059 1.00 94.82  ?  89  MET A CB  1 
ATOM   555  C  CG  . MET A 1 89  ? -33.995 3.643   -33.665 1.00 95.17  ?  89  MET A CG  1 
ATOM   556  S  SD  . MET A 1 89  ? -35.046 5.109   -33.648 1.00 100.06 ?  89  MET A SD  1 
ATOM   557  C  CE  . MET A 1 89  ? -34.438 5.932   -32.175 1.00 98.62  ?  89  MET A CE  1 
ATOM   558  N  N   . LEU A 1 90  ? -35.202 2.259   -38.074 1.00 104.98 ?  90  LEU A N   1 
ATOM   559  C  CA  . LEU A 1 90  ? -34.987 1.687   -39.435 1.00 109.48 ?  90  LEU A CA  1 
ATOM   560  C  C   . LEU A 1 90  ? -34.695 2.813   -40.424 1.00 110.90 ?  90  LEU A C   1 
ATOM   561  O  O   . LEU A 1 90  ? -35.618 3.392   -40.996 1.00 107.89 ?  90  LEU A O   1 
ATOM   562  C  CB  . LEU A 1 90  ? -36.229 0.890   -39.848 1.00 113.30 ?  90  LEU A CB  1 
ATOM   563  C  CG  . LEU A 1 90  ? -36.584 -0.296  -38.950 1.00 116.42 ?  90  LEU A CG  1 
ATOM   564  C  CD1 . LEU A 1 90  ? -37.921 -0.896  -39.358 1.00 119.82 ?  90  LEU A CD1 1 
ATOM   565  C  CD2 . LEU A 1 90  ? -35.494 -1.358  -38.978 1.00 115.39 ?  90  LEU A CD2 1 
ATOM   566  N  N   . PRO A 1 91  ? -33.406 3.162   -40.655 1.00 113.41 ?  91  PRO A N   1 
ATOM   567  C  CA  . PRO A 1 91  ? -33.050 4.235   -41.583 1.00 113.36 ?  91  PRO A CA  1 
ATOM   568  C  C   . PRO A 1 91  ? -33.167 3.838   -43.063 1.00 112.43 ?  91  PRO A C   1 
ATOM   569  O  O   . PRO A 1 91  ? -33.150 2.655   -43.360 1.00 108.87 ?  91  PRO A O   1 
ATOM   570  C  CB  . PRO A 1 91  ? -31.578 4.554   -41.259 1.00 115.15 ?  91  PRO A CB  1 
ATOM   571  C  CG  . PRO A 1 91  ? -31.244 3.725   -40.027 1.00 115.51 ?  91  PRO A CG  1 
ATOM   572  C  CD  . PRO A 1 91  ? -32.216 2.564   -40.032 1.00 113.62 ?  91  PRO A CD  1 
ATOM   573  N  N   . ALA A 1 92  ? -33.276 4.844   -43.939 1.00 111.42 ?  92  ALA A N   1 
ATOM   574  C  CA  . ALA A 1 92  ? -33.276 4.720   -45.417 1.00 109.62 ?  92  ALA A CA  1 
ATOM   575  C  C   . ALA A 1 92  ? -34.201 3.577   -45.856 1.00 107.98 ?  92  ALA A C   1 
ATOM   576  O  O   . ALA A 1 92  ? -33.713 2.627   -46.497 1.00 107.22 ?  92  ALA A O   1 
ATOM   577  C  CB  . ALA A 1 92  ? -31.865 4.512   -45.914 1.00 110.25 ?  92  ALA A CB  1 
ATOM   578  N  N   . MET A 1 93  ? -35.484 3.667   -45.499 1.00 107.60 ?  93  MET A N   1 
ATOM   579  C  CA  . MET A 1 93  ? -36.567 2.784   -46.012 1.00 106.64 ?  93  MET A CA  1 
ATOM   580  C  C   . MET A 1 93  ? -37.236 3.487   -47.198 1.00 108.13 ?  93  MET A C   1 
ATOM   581  O  O   . MET A 1 93  ? -37.370 4.727   -47.145 1.00 103.44 ?  93  MET A O   1 
ATOM   582  C  CB  . MET A 1 93  ? -37.609 2.494   -44.929 1.00 105.27 ?  93  MET A CB  1 
ATOM   583  C  CG  . MET A 1 93  ? -37.046 1.777   -43.712 1.00 105.31 ?  93  MET A CG  1 
ATOM   584  S  SD  . MET A 1 93  ? -36.412 0.122   -44.079 1.00 105.90 ?  93  MET A SD  1 
ATOM   585  C  CE  . MET A 1 93  ? -37.913 -0.714  -44.589 1.00 108.60 ?  93  MET A CE  1 
ATOM   586  N  N   . GLU A 1 94  ? -37.633 2.720   -48.220 1.00 111.57 ?  94  GLU A N   1 
ATOM   587  C  CA  . GLU A 1 94  ? -38.168 3.235   -49.512 1.00 111.47 ?  94  GLU A CA  1 
ATOM   588  C  C   . GLU A 1 94  ? -39.675 2.961   -49.594 1.00 110.77 ?  94  GLU A C   1 
ATOM   589  O  O   . GLU A 1 94  ? -40.063 1.782   -49.472 1.00 108.08 ?  94  GLU A O   1 
ATOM   590  C  CB  . GLU A 1 94  ? -37.428 2.580   -50.680 1.00 108.70 ?  94  GLU A CB  1 
ATOM   591  N  N   . THR A 1 95  ? -40.483 4.010   -49.804 1.00 112.73 ?  95  THR A N   1 
ATOM   592  C  CA  . THR A 1 95  ? -41.949 3.909   -50.071 1.00 115.08 ?  95  THR A CA  1 
ATOM   593  C  C   . THR A 1 95  ? -42.164 3.336   -51.478 1.00 120.89 ?  95  THR A C   1 
ATOM   594  O  O   . THR A 1 95  ? -41.192 3.317   -52.262 1.00 124.01 ?  95  THR A O   1 
ATOM   595  C  CB  . THR A 1 95  ? -42.658 5.265   -49.939 1.00 111.39 ?  95  THR A CB  1 
ATOM   596  O  OG1 . THR A 1 95  ? -42.058 6.188   -50.849 1.00 108.82 ?  95  THR A OG1 1 
ATOM   597  C  CG2 . THR A 1 95  ? -42.596 5.831   -48.539 1.00 111.59 ?  95  THR A CG2 1 
ATOM   598  N  N   . SER A 1 96  ? -43.386 2.880   -51.777 1.00 124.53 ?  96  SER A N   1 
ATOM   599  C  CA  . SER A 1 96  ? -43.813 2.462   -53.144 1.00 124.52 ?  96  SER A CA  1 
ATOM   600  C  C   . SER A 1 96  ? -43.485 3.576   -54.149 1.00 125.01 ?  96  SER A C   1 
ATOM   601  O  O   . SER A 1 96  ? -42.953 3.259   -55.232 1.00 125.78 ?  96  SER A O   1 
ATOM   602  C  CB  . SER A 1 96  ? -45.276 2.098   -53.191 1.00 124.54 ?  96  SER A CB  1 
ATOM   603  O  OG  . SER A 1 96  ? -46.090 3.215   -52.862 1.00 125.02 ?  96  SER A OG  1 
ATOM   604  N  N   . ASP A 1 97  ? -43.790 4.826   -53.779 1.00 122.79 ?  97  ASP A N   1 
ATOM   605  C  CA  . ASP A 1 97  ? -43.485 6.063   -54.551 1.00 121.29 ?  97  ASP A CA  1 
ATOM   606  C  C   . ASP A 1 97  ? -42.036 6.006   -55.050 1.00 120.07 ?  97  ASP A C   1 
ATOM   607  O  O   . ASP A 1 97  ? -41.836 6.018   -56.279 1.00 119.94 ?  97  ASP A O   1 
ATOM   608  C  CB  . ASP A 1 97  ? -43.739 7.307   -53.691 1.00 121.71 ?  97  ASP A CB  1 
ATOM   609  C  CG  . ASP A 1 97  ? -43.573 8.640   -54.404 1.00 122.22 ?  97  ASP A CG  1 
ATOM   610  O  OD1 . ASP A 1 97  ? -42.977 8.660   -55.499 1.00 121.11 ?  97  ASP A OD1 1 
ATOM   611  O  OD2 . ASP A 1 97  ? -44.036 9.657   -53.848 1.00 123.74 ?  97  ASP A OD2 1 
ATOM   612  N  N   . GLY A 1 98  ? -41.075 5.923   -54.123 1.00 119.52 ?  98  GLY A N   1 
ATOM   613  C  CA  . GLY A 1 98  ? -39.628 6.017   -54.408 1.00 115.79 ?  98  GLY A CA  1 
ATOM   614  C  C   . GLY A 1 98  ? -38.919 7.016   -53.505 1.00 114.98 ?  98  GLY A C   1 
ATOM   615  O  O   . GLY A 1 98  ? -37.677 7.084   -53.582 1.00 117.60 ?  98  GLY A O   1 
ATOM   616  N  N   . ARG A 1 99  ? -39.665 7.771   -52.685 1.00 111.35 ?  99  ARG A N   1 
ATOM   617  C  CA  . ARG A 1 99  ? -39.097 8.686   -51.653 1.00 104.63 ?  99  ARG A CA  1 
ATOM   618  C  C   . ARG A 1 99  ? -38.444 7.840   -50.551 1.00 103.18 ?  99  ARG A C   1 
ATOM   619  O  O   . ARG A 1 99  ? -38.903 6.697   -50.337 1.00 101.86 ?  99  ARG A O   1 
ATOM   620  C  CB  . ARG A 1 99  ? -40.182 9.602   -51.075 1.00 102.96 ?  99  ARG A CB  1 
ATOM   621  C  CG  . ARG A 1 99  ? -41.101 10.222  -52.118 1.00 102.80 ?  99  ARG A CG  1 
ATOM   622  C  CD  . ARG A 1 99  ? -41.831 11.459  -51.630 1.00 102.25 ?  99  ARG A CD  1 
ATOM   623  N  NE  . ARG A 1 99  ? -42.941 11.806  -52.512 1.00 105.39 ?  99  ARG A NE  1 
ATOM   624  C  CZ  . ARG A 1 99  ? -43.573 12.980  -52.538 1.00 107.46 ?  99  ARG A CZ  1 
ATOM   625  N  NH1 . ARG A 1 99  ? -43.214 13.963  -51.728 1.00 107.45 ?  99  ARG A NH1 1 
ATOM   626  N  NH2 . ARG A 1 99  ? -44.568 13.170  -53.387 1.00 107.77 ?  99  ARG A NH2 1 
ATOM   627  N  N   . SER A 1 100 ? -37.419 8.381   -49.881 1.00 100.41 ?  100 SER A N   1 
ATOM   628  C  CA  . SER A 1 100 ? -36.615 7.669   -48.845 1.00 98.25  ?  100 SER A CA  1 
ATOM   629  C  C   . SER A 1 100 ? -36.859 8.299   -47.467 1.00 95.99  ?  100 SER A C   1 
ATOM   630  O  O   . SER A 1 100 ? -36.689 9.530   -47.345 1.00 93.17  ?  100 SER A O   1 
ATOM   631  C  CB  . SER A 1 100 ? -35.150 7.671   -49.194 1.00 96.35  ?  100 SER A CB  1 
ATOM   632  O  OG  . SER A 1 100 ? -34.458 6.664   -48.471 1.00 95.66  ?  100 SER A OG  1 
ATOM   633  N  N   . PHE A 1 101 ? -37.235 7.482   -46.474 1.00 92.54  ?  101 PHE A N   1 
ATOM   634  C  CA  . PHE A 1 101 ? -37.582 7.922   -45.094 1.00 90.44  ?  101 PHE A CA  1 
ATOM   635  C  C   . PHE A 1 101 ? -36.800 7.114   -44.049 1.00 87.70  ?  101 PHE A C   1 
ATOM   636  O  O   . PHE A 1 101 ? -36.500 5.927   -44.288 1.00 86.96  ?  101 PHE A O   1 
ATOM   637  C  CB  . PHE A 1 101 ? -39.086 7.784   -44.843 1.00 90.92  ?  101 PHE A CB  1 
ATOM   638  C  CG  . PHE A 1 101 ? -39.950 8.728   -45.642 1.00 91.55  ?  101 PHE A CG  1 
ATOM   639  C  CD1 . PHE A 1 101 ? -40.109 10.049  -45.252 1.00 92.51  ?  101 PHE A CD1 1 
ATOM   640  C  CD2 . PHE A 1 101 ? -40.604 8.295   -46.784 1.00 91.71  ?  101 PHE A CD2 1 
ATOM   641  C  CE1 . PHE A 1 101 ? -40.902 10.916  -45.989 1.00 94.57  ?  101 PHE A CE1 1 
ATOM   642  C  CE2 . PHE A 1 101 ? -41.396 9.163   -47.520 1.00 92.00  ?  101 PHE A CE2 1 
ATOM   643  C  CZ  . PHE A 1 101 ? -41.543 10.472  -47.122 1.00 92.65  ?  101 PHE A CZ  1 
ATOM   644  N  N   . ASP A 1 102 ? -36.476 7.763   -42.926 1.00 85.24  ?  102 ASP A N   1 
ATOM   645  C  CA  . ASP A 1 102 ? -36.039 7.113   -41.660 1.00 83.49  ?  102 ASP A CA  1 
ATOM   646  C  C   . ASP A 1 102 ? -37.295 6.827   -40.829 1.00 80.91  ?  102 ASP A C   1 
ATOM   647  O  O   . ASP A 1 102 ? -38.081 7.773   -40.615 1.00 77.79  ?  102 ASP A O   1 
ATOM   648  C  CB  . ASP A 1 102 ? -35.056 7.998   -40.886 1.00 84.27  ?  102 ASP A CB  1 
ATOM   649  C  CG  . ASP A 1 102 ? -33.690 8.160   -41.532 1.00 82.66  ?  102 ASP A CG  1 
ATOM   650  O  OD1 . ASP A 1 102 ? -33.256 7.232   -42.243 1.00 81.58  ?  102 ASP A OD1 1 
ATOM   651  O  OD2 . ASP A 1 102 ? -33.072 9.222   -41.322 1.00 80.79  ?  102 ASP A OD2 1 
ATOM   652  N  N   . ILE A 1 103 ? -37.482 5.581   -40.385 1.00 79.83  ?  103 ILE A N   1 
ATOM   653  C  CA  . ILE A 1 103 ? -38.763 5.115   -39.770 1.00 82.28  ?  103 ILE A CA  1 
ATOM   654  C  C   . ILE A 1 103 ? -38.519 4.648   -38.331 1.00 78.39  ?  103 ILE A C   1 
ATOM   655  O  O   . ILE A 1 103 ? -37.720 3.712   -38.135 1.00 76.43  ?  103 ILE A O   1 
ATOM   656  C  CB  . ILE A 1 103 ? -39.422 4.020   -40.632 1.00 82.90  ?  103 ILE A CB  1 
ATOM   657  C  CG1 . ILE A 1 103 ? -39.842 4.572   -41.997 1.00 85.31  ?  103 ILE A CG1 1 
ATOM   658  C  CG2 . ILE A 1 103 ? -40.594 3.384   -39.896 1.00 83.83  ?  103 ILE A CG2 1 
ATOM   659  C  CD1 . ILE A 1 103 ? -40.328 3.523   -42.968 1.00 87.30  ?  103 ILE A CD1 1 
ATOM   660  N  N   . SER A 1 104 ? -39.196 5.290   -37.373 1.00 76.56  ?  104 SER A N   1 
ATOM   661  C  CA  . SER A 1 104 ? -39.306 4.843   -35.959 1.00 79.07  ?  104 SER A CA  1 
ATOM   662  C  C   . SER A 1 104 ? -40.617 4.069   -35.782 1.00 78.62  ?  104 SER A C   1 
ATOM   663  O  O   . SER A 1 104 ? -41.693 4.688   -35.889 1.00 74.04  ?  104 SER A O   1 
ATOM   664  C  CB  . SER A 1 104 ? -39.218 6.001   -34.998 1.00 81.07  ?  104 SER A CB  1 
ATOM   665  O  OG  . SER A 1 104 ? -38.034 6.752   -35.213 1.00 81.44  ?  104 SER A OG  1 
ATOM   666  N  N   . LEU A 1 105 ? -40.509 2.762   -35.525 1.00 79.49  ?  105 LEU A N   1 
ATOM   667  C  CA  . LEU A 1 105 ? -41.643 1.819   -35.346 1.00 78.79  ?  105 LEU A CA  1 
ATOM   668  C  C   . LEU A 1 105 ? -41.650 1.315   -33.901 1.00 78.05  ?  105 LEU A C   1 
ATOM   669  O  O   . LEU A 1 105 ? -40.610 0.798   -33.456 1.00 81.83  ?  105 LEU A O   1 
ATOM   670  C  CB  . LEU A 1 105 ? -41.460 0.657   -36.326 1.00 83.22  ?  105 LEU A CB  1 
ATOM   671  C  CG  . LEU A 1 105 ? -42.464 -0.487  -36.197 1.00 86.11  ?  105 LEU A CG  1 
ATOM   672  C  CD1 . LEU A 1 105 ? -43.816 -0.080  -36.755 1.00 88.87  ?  105 LEU A CD1 1 
ATOM   673  C  CD2 . LEU A 1 105 ? -41.952 -1.733  -36.899 1.00 88.20  ?  105 LEU A CD2 1 
ATOM   674  N  N   . HIS A 1 106 ? -42.778 1.456   -33.203 1.00 74.02  ?  106 HIS A N   1 
ATOM   675  C  CA  . HIS A 1 106 ? -42.976 0.940   -31.822 1.00 72.03  ?  106 HIS A CA  1 
ATOM   676  C  C   . HIS A 1 106 ? -44.438 0.541   -31.626 1.00 75.18  ?  106 HIS A C   1 
ATOM   677  O  O   . HIS A 1 106 ? -45.291 0.980   -32.421 1.00 75.90  ?  106 HIS A O   1 
ATOM   678  C  CB  . HIS A 1 106 ? -42.513 1.966   -30.778 1.00 70.40  ?  106 HIS A CB  1 
ATOM   679  C  CG  . HIS A 1 106 ? -43.546 2.967   -30.373 1.00 67.39  ?  106 HIS A CG  1 
ATOM   680  N  ND1 . HIS A 1 106 ? -43.683 4.187   -31.007 1.00 65.07  ?  106 HIS A ND1 1 
ATOM   681  C  CD2 . HIS A 1 106 ? -44.469 2.948   -29.386 1.00 66.39  ?  106 HIS A CD2 1 
ATOM   682  C  CE1 . HIS A 1 106 ? -44.651 4.874   -30.431 1.00 64.61  ?  106 HIS A CE1 1 
ATOM   683  N  NE2 . HIS A 1 106 ? -45.151 4.134   -29.433 1.00 65.21  ?  106 HIS A NE2 1 
ATOM   684  N  N   . ARG A 1 107 ? -44.696 -0.261  -30.594 1.00 78.37  ?  107 ARG A N   1 
ATOM   685  C  CA  . ARG A 1 107 ? -46.058 -0.743  -30.236 1.00 79.82  ?  107 ARG A CA  1 
ATOM   686  C  C   . ARG A 1 107 ? -46.270 -0.534  -28.735 1.00 76.97  ?  107 ARG A C   1 
ATOM   687  O  O   . ARG A 1 107 ? -45.430 -1.009  -27.946 1.00 77.48  ?  107 ARG A O   1 
ATOM   688  C  CB  . ARG A 1 107 ? -46.214 -2.212  -30.641 1.00 86.45  ?  107 ARG A CB  1 
ATOM   689  C  CG  . ARG A 1 107 ? -47.627 -2.608  -31.044 1.00 92.49  ?  107 ARG A CG  1 
ATOM   690  C  CD  . ARG A 1 107 ? -47.702 -4.078  -31.405 1.00 97.20  ?  107 ARG A CD  1 
ATOM   691  N  NE  . ARG A 1 107 ? -47.350 -4.913  -30.263 1.00 103.35 ?  107 ARG A NE  1 
ATOM   692  C  CZ  . ARG A 1 107 ? -46.987 -6.192  -30.323 1.00 107.55 ?  107 ARG A CZ  1 
ATOM   693  N  NH1 . ARG A 1 107 ? -46.916 -6.822  -31.485 1.00 105.55 ?  107 ARG A NH1 1 
ATOM   694  N  NH2 . ARG A 1 107 ? -46.689 -6.835  -29.207 1.00 111.07 ?  107 ARG A NH2 1 
ATOM   695  N  N   . TYR A 1 108 ? -47.342 0.171   -28.367 1.00 75.56  ?  108 TYR A N   1 
ATOM   696  C  CA  . TYR A 1 108 ? -47.699 0.504   -26.962 1.00 75.60  ?  108 TYR A CA  1 
ATOM   697  C  C   . TYR A 1 108 ? -49.220 0.618   -26.841 1.00 76.74  ?  108 TYR A C   1 
ATOM   698  O  O   . TYR A 1 108 ? -49.837 1.276   -27.706 1.00 77.70  ?  108 TYR A O   1 
ATOM   699  C  CB  . TYR A 1 108 ? -47.008 1.798   -26.528 1.00 74.45  ?  108 TYR A CB  1 
ATOM   700  C  CG  . TYR A 1 108 ? -47.271 2.210   -25.102 1.00 73.33  ?  108 TYR A CG  1 
ATOM   701  C  CD1 . TYR A 1 108 ? -46.988 1.356   -24.046 1.00 73.70  ?  108 TYR A CD1 1 
ATOM   702  C  CD2 . TYR A 1 108 ? -47.787 3.460   -24.802 1.00 73.34  ?  108 TYR A CD2 1 
ATOM   703  C  CE1 . TYR A 1 108 ? -47.219 1.728   -22.731 1.00 75.13  ?  108 TYR A CE1 1 
ATOM   704  C  CE2 . TYR A 1 108 ? -48.023 3.848   -23.493 1.00 76.48  ?  108 TYR A CE2 1 
ATOM   705  C  CZ  . TYR A 1 108 ? -47.737 2.981   -22.453 1.00 76.55  ?  108 TYR A CZ  1 
ATOM   706  O  OH  . TYR A 1 108 ? -47.966 3.362   -21.162 1.00 77.91  ?  108 TYR A OH  1 
ATOM   707  N  N   . LYS A 1 109 ? -49.785 0.012   -25.790 1.00 78.87  ?  109 LYS A N   1 
ATOM   708  C  CA  . LYS A 1 109 ? -51.251 -0.103  -25.552 1.00 81.92  ?  109 LYS A CA  1 
ATOM   709  C  C   . LYS A 1 109 ? -51.898 -0.711  -26.805 1.00 81.71  ?  109 LYS A C   1 
ATOM   710  O  O   . LYS A 1 109 ? -52.868 -0.124  -27.337 1.00 75.01  ?  109 LYS A O   1 
ATOM   711  C  CB  . LYS A 1 109 ? -51.830 1.259   -25.153 1.00 84.09  ?  109 LYS A CB  1 
ATOM   712  C  CG  . LYS A 1 109 ? -51.378 1.757   -23.786 1.00 87.64  ?  109 LYS A CG  1 
ATOM   713  C  CD  . LYS A 1 109 ? -51.995 3.077   -23.383 1.00 92.46  ?  109 LYS A CD  1 
ATOM   714  C  CE  . LYS A 1 109 ? -51.916 3.336   -21.893 1.00 96.37  ?  109 LYS A CE  1 
ATOM   715  N  NZ  . LYS A 1 109 ? -52.678 4.547   -21.505 1.00 98.40  ?  109 LYS A NZ  1 
ATOM   716  N  N   . SER A 1 110 ? -51.337 -1.836  -27.262 1.00 83.49  ?  110 SER A N   1 
ATOM   717  C  CA  . SER A 1 110 ? -51.808 -2.642  -28.424 1.00 88.91  ?  110 SER A CA  1 
ATOM   718  C  C   . SER A 1 110 ? -52.199 -1.723  -29.592 1.00 88.82  ?  110 SER A C   1 
ATOM   719  O  O   . SER A 1 110 ? -53.262 -1.950  -30.209 1.00 91.72  ?  110 SER A O   1 
ATOM   720  C  CB  . SER A 1 110 ? -52.934 -3.558  -28.014 1.00 93.86  ?  110 SER A CB  1 
ATOM   721  O  OG  . SER A 1 110 ? -52.579 -4.312  -26.861 1.00 95.24  ?  110 SER A OG  1 
ATOM   722  N  N   . THR A 1 111 ? -51.357 -0.722  -29.870 1.00 86.76  ?  111 THR A N   1 
ATOM   723  C  CA  . THR A 1 111 ? -51.451 0.206   -31.033 1.00 81.66  ?  111 THR A CA  1 
ATOM   724  C  C   . THR A 1 111 ? -50.059 0.345   -31.650 1.00 79.41  ?  111 THR A C   1 
ATOM   725  O  O   . THR A 1 111 ? -49.131 0.712   -30.907 1.00 87.04  ?  111 THR A O   1 
ATOM   726  C  CB  . THR A 1 111 ? -51.977 1.585   -30.612 1.00 81.13  ?  111 THR A CB  1 
ATOM   727  O  OG1 . THR A 1 111 ? -53.166 1.382   -29.847 1.00 86.01  ?  111 THR A OG1 1 
ATOM   728  C  CG2 . THR A 1 111 ? -52.258 2.504   -31.782 1.00 79.39  ?  111 THR A CG2 1 
ATOM   729  N  N   . THR A 1 112 ? -49.921 0.059   -32.945 1.00 75.25  ?  112 THR A N   1 
ATOM   730  C  CA  . THR A 1 112 ? -48.632 0.188   -33.684 1.00 73.59  ?  112 THR A CA  1 
ATOM   731  C  C   . THR A 1 112 ? -48.487 1.619   -34.205 1.00 74.32  ?  112 THR A C   1 
ATOM   732  O  O   . THR A 1 112 ? -49.350 2.049   -34.989 1.00 79.32  ?  112 THR A O   1 
ATOM   733  C  CB  . THR A 1 112 ? -48.520 -0.800  -34.848 1.00 71.56  ?  112 THR A CB  1 
ATOM   734  O  OG1 . THR A 1 112 ? -48.532 -2.112  -34.285 1.00 69.76  ?  112 THR A OG1 1 
ATOM   735  C  CG2 . THR A 1 112 ? -47.267 -0.583  -35.670 1.00 71.18  ?  112 THR A CG2 1 
ATOM   736  N  N   . ILE A 1 113 ? -47.420 2.311   -33.801 1.00 72.69  ?  113 ILE A N   1 
ATOM   737  C  CA  . ILE A 1 113 ? -47.140 3.717   -34.214 1.00 72.36  ?  113 ILE A CA  1 
ATOM   738  C  C   . ILE A 1 113 ? -45.891 3.723   -35.101 1.00 71.77  ?  113 ILE A C   1 
ATOM   739  O  O   . ILE A 1 113 ? -44.887 3.088   -34.729 1.00 73.25  ?  113 ILE A O   1 
ATOM   740  C  CB  . ILE A 1 113 ? -47.036 4.630   -32.977 1.00 71.53  ?  113 ILE A CB  1 
ATOM   741  C  CG1 . ILE A 1 113 ? -48.387 4.714   -32.259 1.00 71.49  ?  113 ILE A CG1 1 
ATOM   742  C  CG2 . ILE A 1 113 ? -46.507 6.007   -33.355 1.00 72.55  ?  113 ILE A CG2 1 
ATOM   743  C  CD1 . ILE A 1 113 ? -48.317 5.216   -30.835 1.00 72.72  ?  113 ILE A CD1 1 
ATOM   744  N  N   . ILE A 1 114 ? -45.992 4.385   -36.257 1.00 73.28  ?  114 ILE A N   1 
ATOM   745  C  CA  . ILE A 1 114 ? -44.933 4.470   -37.305 1.00 72.81  ?  114 ILE A CA  1 
ATOM   746  C  C   . ILE A 1 114 ? -44.655 5.951   -37.562 1.00 71.91  ?  114 ILE A C   1 
ATOM   747  O  O   . ILE A 1 114 ? -45.589 6.665   -37.977 1.00 71.79  ?  114 ILE A O   1 
ATOM   748  C  CB  . ILE A 1 114 ? -45.360 3.752   -38.601 1.00 76.14  ?  114 ILE A CB  1 
ATOM   749  C  CG1 . ILE A 1 114 ? -46.018 2.397   -38.325 1.00 79.07  ?  114 ILE A CG1 1 
ATOM   750  C  CG2 . ILE A 1 114 ? -44.182 3.624   -39.556 1.00 77.09  ?  114 ILE A CG2 1 
ATOM   751  C  CD1 . ILE A 1 114 ? -46.748 1.821   -39.515 1.00 80.02  ?  114 ILE A CD1 1 
ATOM   752  N  N   . GLU A 1 115 ? -43.418 6.382   -37.323 1.00 72.46  ?  115 GLU A N   1 
ATOM   753  C  CA  . GLU A 1 115 ? -42.986 7.793   -37.491 1.00 72.85  ?  115 GLU A CA  1 
ATOM   754  C  C   . GLU A 1 115 ? -42.037 7.867   -38.689 1.00 73.37  ?  115 GLU A C   1 
ATOM   755  O  O   . GLU A 1 115 ? -41.105 7.042   -38.755 1.00 70.00  ?  115 GLU A O   1 
ATOM   756  C  CB  . GLU A 1 115 ? -42.351 8.296   -36.197 1.00 73.35  ?  115 GLU A CB  1 
ATOM   757  C  CG  . GLU A 1 115 ? -43.335 8.353   -35.045 1.00 73.00  ?  115 GLU A CG  1 
ATOM   758  C  CD  . GLU A 1 115 ? -42.695 8.588   -33.693 1.00 71.80  ?  115 GLU A CD  1 
ATOM   759  O  OE1 . GLU A 1 115 ? -42.154 7.616   -33.128 1.00 76.03  ?  115 GLU A OE1 1 
ATOM   760  O  OE2 . GLU A 1 115 ? -42.724 9.741   -33.223 1.00 67.52  ?  115 GLU A OE2 1 
ATOM   761  N  N   . PHE A 1 116 ? -42.299 8.808   -39.599 1.00 73.85  ?  116 PHE A N   1 
ATOM   762  C  CA  . PHE A 1 116 ? -41.552 9.012   -40.866 1.00 72.10  ?  116 PHE A CA  1 
ATOM   763  C  C   . PHE A 1 116 ? -40.746 10.302  -40.767 1.00 69.33  ?  116 PHE A C   1 
ATOM   764  O  O   . PHE A 1 116 ? -41.302 11.317  -40.321 1.00 65.80  ?  116 PHE A O   1 
ATOM   765  C  CB  . PHE A 1 116 ? -42.509 9.060   -42.058 1.00 75.56  ?  116 PHE A CB  1 
ATOM   766  C  CG  . PHE A 1 116 ? -43.244 7.768   -42.301 1.00 78.34  ?  116 PHE A CG  1 
ATOM   767  C  CD1 . PHE A 1 116 ? -42.689 6.775   -43.094 1.00 79.28  ?  116 PHE A CD1 1 
ATOM   768  C  CD2 . PHE A 1 116 ? -44.481 7.538   -41.717 1.00 78.37  ?  116 PHE A CD2 1 
ATOM   769  C  CE1 . PHE A 1 116 ? -43.361 5.582   -43.307 1.00 80.54  ?  116 PHE A CE1 1 
ATOM   770  C  CE2 . PHE A 1 116 ? -45.151 6.343   -41.930 1.00 79.61  ?  116 PHE A CE2 1 
ATOM   771  C  CZ  . PHE A 1 116 ? -44.590 5.368   -42.723 1.00 81.30  ?  116 PHE A CZ  1 
ATOM   772  N  N   . GLU A 1 117 ? -39.480 10.236  -41.181 1.00 73.82  ?  117 GLU A N   1 
ATOM   773  C  CA  . GLU A 1 117 ? -38.533 11.380  -41.233 1.00 78.48  ?  117 GLU A CA  1 
ATOM   774  C  C   . GLU A 1 117 ? -37.867 11.425  -42.601 1.00 80.26  ?  117 GLU A C   1 
ATOM   775  O  O   . GLU A 1 117 ? -37.404 10.397  -43.091 1.00 78.65  ?  117 GLU A O   1 
ATOM   776  C  CB  . GLU A 1 117 ? -37.435 11.218  -40.185 1.00 83.57  ?  117 GLU A CB  1 
ATOM   777  C  CG  . GLU A 1 117 ? -37.769 11.812  -38.837 1.00 85.66  ?  117 GLU A CG  1 
ATOM   778  C  CD  . GLU A 1 117 ? -36.604 11.699  -37.873 1.00 85.32  ?  117 GLU A CD  1 
ATOM   779  O  OE1 . GLU A 1 117 ? -36.155 10.558  -37.629 1.00 81.28  ?  117 GLU A OE1 1 
ATOM   780  O  OE2 . GLU A 1 117 ? -36.124 12.752  -37.403 1.00 87.79  ?  117 GLU A OE2 1 
ATOM   781  N  N   . PRO A 1 118 ? -37.789 12.606  -43.252 1.00 83.58  ?  118 PRO A N   1 
ATOM   782  C  CA  . PRO A 1 118 ? -36.962 12.761  -44.446 1.00 85.94  ?  118 PRO A CA  1 
ATOM   783  C  C   . PRO A 1 118 ? -35.510 12.370  -44.133 1.00 86.94  ?  118 PRO A C   1 
ATOM   784  O  O   . PRO A 1 118 ? -34.912 12.997  -43.279 1.00 89.44  ?  118 PRO A O   1 
ATOM   785  C  CB  . PRO A 1 118 ? -37.076 14.252  -44.803 1.00 88.11  ?  118 PRO A CB  1 
ATOM   786  C  CG  . PRO A 1 118 ? -38.343 14.723  -44.109 1.00 87.67  ?  118 PRO A CG  1 
ATOM   787  C  CD  . PRO A 1 118 ? -38.485 13.848  -42.881 1.00 86.34  ?  118 PRO A CD  1 
ATOM   788  N  N   . SER A 1 119 ? -35.003 11.330  -44.799 1.00 88.11  ?  119 SER A N   1 
ATOM   789  C  CA  . SER A 1 119 ? -33.596 10.852  -44.678 1.00 89.79  ?  119 SER A CA  1 
ATOM   790  C  C   . SER A 1 119 ? -32.783 11.328  -45.888 1.00 92.88  ?  119 SER A C   1 
ATOM   791  O  O   . SER A 1 119 ? -31.760 12.002  -45.657 1.00 95.63  ?  119 SER A O   1 
ATOM   792  C  CB  . SER A 1 119 ? -33.534 9.356   -44.528 1.00 89.11  ?  119 SER A CB  1 
ATOM   793  O  OG  . SER A 1 119 ? -33.704 8.709   -45.779 1.00 93.35  ?  119 SER A OG  1 
ATOM   794  N  N   . SER A 1 121 ? -30.575 11.349  -43.339 1.00 128.30 ?  121 SER A N   1 
ATOM   795  C  CA  . SER A 1 121 ? -29.094 11.489  -43.335 1.00 131.77 ?  121 SER A CA  1 
ATOM   796  C  C   . SER A 1 121 ? -28.436 10.144  -43.672 1.00 135.23 ?  121 SER A C   1 
ATOM   797  O  O   . SER A 1 121 ? -29.162 9.131   -43.765 1.00 129.89 ?  121 SER A O   1 
ATOM   798  C  CB  . SER A 1 121 ? -28.603 12.016  -42.012 1.00 129.70 ?  121 SER A CB  1 
ATOM   799  O  OG  . SER A 1 121 ? -27.190 12.153  -42.005 1.00 129.11 ?  121 SER A OG  1 
ATOM   800  N  N   . ASP A 1 122 ? -27.110 10.152  -43.848 1.00 139.92 ?  122 ASP A N   1 
ATOM   801  C  CA  . ASP A 1 122 ? -26.272 8.941   -44.069 1.00 139.32 ?  122 ASP A CA  1 
ATOM   802  C  C   . ASP A 1 122 ? -24.884 9.166   -43.459 1.00 138.43 ?  122 ASP A C   1 
ATOM   803  O  O   . ASP A 1 122 ? -23.991 9.678   -44.164 1.00 133.87 ?  122 ASP A O   1 
ATOM   804  C  CB  . ASP A 1 122 ? -26.205 8.573   -45.553 1.00 138.28 ?  122 ASP A CB  1 
ATOM   805  C  CG  . ASP A 1 122 ? -27.358 7.691   -45.996 1.00 139.11 ?  122 ASP A CG  1 
ATOM   806  O  OD1 . ASP A 1 122 ? -27.373 6.509   -45.600 1.00 135.69 ?  122 ASP A OD1 1 
ATOM   807  O  OD2 . ASP A 1 122 ? -28.242 8.199   -46.714 1.00 142.43 ?  122 ASP A OD2 1 
ATOM   808  N  N   . THR A 1 123 ? -24.747 8.815   -42.178 1.00 139.86 ?  123 THR A N   1 
ATOM   809  C  CA  . THR A 1 123 ? -23.457 8.733   -41.429 1.00 138.71 ?  123 THR A CA  1 
ATOM   810  C  C   . THR A 1 123 ? -23.445 7.432   -40.617 1.00 135.53 ?  123 THR A C   1 
ATOM   811  O  O   . THR A 1 123 ? -24.500 6.765   -40.567 1.00 133.56 ?  123 THR A O   1 
ATOM   812  C  CB  . THR A 1 123 ? -23.237 9.969   -40.542 1.00 139.83 ?  123 THR A CB  1 
ATOM   813  O  OG1 . THR A 1 123 ? -24.334 10.093  -39.637 1.00 135.86 ?  123 THR A OG1 1 
ATOM   814  C  CG2 . THR A 1 123 ? -23.096 11.249  -41.339 1.00 138.65 ?  123 THR A CG2 1 
ATOM   815  N  N   . GLN A 1 124 ? -22.299 7.086   -40.021 1.00 131.37 ?  124 GLN A N   1 
ATOM   816  C  CA  . GLN A 1 124 ? -22.129 5.887   -39.155 1.00 125.63 ?  124 GLN A CA  1 
ATOM   817  C  C   . GLN A 1 124 ? -22.589 6.235   -37.740 1.00 119.34 ?  124 GLN A C   1 
ATOM   818  O  O   . GLN A 1 124 ? -21.973 7.072   -37.081 1.00 114.37 ?  124 GLN A O   1 
ATOM   819  C  CB  . GLN A 1 124 ? -20.671 5.420   -39.170 1.00 124.43 ?  124 GLN A CB  1 
ATOM   820  N  N   . PRO A 1 125 ? -23.682 5.622   -37.223 1.00 113.95 ?  125 PRO A N   1 
ATOM   821  C  CA  . PRO A 1 125 ? -24.147 5.910   -35.866 1.00 111.50 ?  125 PRO A CA  1 
ATOM   822  C  C   . PRO A 1 125 ? -23.215 5.327   -34.788 1.00 108.40 ?  125 PRO A C   1 
ATOM   823  O  O   . PRO A 1 125 ? -22.919 6.033   -33.841 1.00 109.88 ?  125 PRO A O   1 
ATOM   824  C  CB  . PRO A 1 125 ? -25.554 5.290   -35.820 1.00 109.24 ?  125 PRO A CB  1 
ATOM   825  C  CG  . PRO A 1 125 ? -25.523 4.183   -36.854 1.00 110.58 ?  125 PRO A CG  1 
ATOM   826  C  CD  . PRO A 1 125 ? -24.528 4.629   -37.908 1.00 113.43 ?  125 PRO A CD  1 
ATOM   827  N  N   . LEU A 1 126 ? -22.764 4.079   -34.965 0.80 101.88 ?  126 LEU A N   1 
ATOM   828  C  CA  . LEU A 1 126 ? -21.835 3.378   -34.032 0.80 97.39  ?  126 LEU A CA  1 
ATOM   829  C  C   . LEU A 1 126 ? -20.457 4.055   -34.062 0.80 92.56  ?  126 LEU A C   1 
ATOM   830  O  O   . LEU A 1 126 ? -19.765 4.023   -33.026 0.80 91.40  ?  126 LEU A O   1 
ATOM   831  C  CB  . LEU A 1 126 ? -21.733 1.901   -34.428 1.00 96.32  ?  126 LEU A CB  1 
ATOM   832  N  N   . GLY A 1 127 ? -20.084 4.647   -35.202 1.00 88.80  ?  127 GLY A N   1 
ATOM   833  C  CA  . GLY A 1 127 ? -18.775 5.297   -35.422 1.00 86.40  ?  127 GLY A CA  1 
ATOM   834  C  C   . GLY A 1 127 ? -18.613 6.554   -34.584 1.00 83.14  ?  127 GLY A C   1 
ATOM   835  O  O   . GLY A 1 127 ? -17.590 6.661   -33.879 1.00 79.05  ?  127 GLY A O   1 
ATOM   836  N  N   . THR A 1 128 ? -19.577 7.476   -34.683 1.00 83.28  ?  128 THR A N   1 
ATOM   837  C  CA  . THR A 1 128 ? -19.672 8.726   -33.871 1.00 81.80  ?  128 THR A CA  1 
ATOM   838  C  C   . THR A 1 128 ? -19.676 8.368   -32.378 1.00 75.94  ?  128 THR A C   1 
ATOM   839  O  O   . THR A 1 128 ? -18.865 8.945   -31.624 1.00 73.23  ?  128 THR A O   1 
ATOM   840  C  CB  . THR A 1 128 ? -20.925 9.529   -34.254 1.00 84.03  ?  128 THR A CB  1 
ATOM   841  O  OG1 . THR A 1 128 ? -20.761 9.988   -35.596 1.00 85.92  ?  128 THR A OG1 1 
ATOM   842  C  CG2 . THR A 1 128 ? -21.198 10.711  -33.348 1.00 85.33  ?  128 THR A CG2 1 
ATOM   843  N  N   . ALA A 1 129 ? -20.560 7.446   -31.986 1.00 69.37  ?  129 ALA A N   1 
ATOM   844  C  CA  . ALA A 1 129 ? -20.779 6.991   -30.592 1.00 67.71  ?  129 ALA A CA  1 
ATOM   845  C  C   . ALA A 1 129 ? -19.473 6.451   -29.996 1.00 64.94  ?  129 ALA A C   1 
ATOM   846  O  O   . ALA A 1 129 ? -19.159 6.831   -28.856 1.00 64.76  ?  129 ALA A O   1 
ATOM   847  C  CB  . ALA A 1 129 ? -21.871 5.950   -30.549 1.00 67.67  ?  129 ALA A CB  1 
ATOM   848  N  N   . ARG A 1 130 ? -18.748 5.603   -30.734 1.00 64.64  ?  130 ARG A N   1 
ATOM   849  C  CA  . ARG A 1 130 ? -17.488 4.965   -30.250 1.00 63.77  ?  130 ARG A CA  1 
ATOM   850  C  C   . ARG A 1 130 ? -16.466 6.071   -29.946 1.00 61.54  ?  130 ARG A C   1 
ATOM   851  O  O   . ARG A 1 130 ? -15.864 6.032   -28.859 1.00 61.28  ?  130 ARG A O   1 
ATOM   852  C  CB  . ARG A 1 130 ? -16.959 3.943   -31.263 1.00 61.78  ?  130 ARG A CB  1 
ATOM   853  N  N   . LYS A 1 131 ? -16.301 7.035   -30.857 1.00 61.14  ?  131 LYS A N   1 
ATOM   854  C  CA  . LYS A 1 131 ? -15.388 8.198   -30.682 1.00 63.17  ?  131 LYS A CA  1 
ATOM   855  C  C   . LYS A 1 131 ? -15.707 8.883   -29.343 1.00 63.67  ?  131 LYS A C   1 
ATOM   856  O  O   . LYS A 1 131 ? -14.774 9.057   -28.536 1.00 65.02  ?  131 LYS A O   1 
ATOM   857  C  CB  . LYS A 1 131 ? -15.508 9.168   -31.863 1.00 61.40  ?  131 LYS A CB  1 
ATOM   858  N  N   . MET A 1 132 ? -16.981 9.222   -29.112 1.00 62.08  ?  132 MET A N   1 
ATOM   859  C  CA  . MET A 1 132 ? -17.461 9.953   -27.904 1.00 60.47  ?  132 MET A CA  1 
ATOM   860  C  C   . MET A 1 132 ? -17.275 9.099   -26.642 1.00 57.05  ?  132 MET A C   1 
ATOM   861  O  O   . MET A 1 132 ? -16.810 9.645   -25.630 1.00 56.85  ?  132 MET A O   1 
ATOM   862  C  CB  . MET A 1 132 ? -18.943 10.320  -28.027 1.00 61.45  ?  132 MET A CB  1 
ATOM   863  C  CG  . MET A 1 132 ? -19.233 11.397  -29.046 1.00 62.30  ?  132 MET A CG  1 
ATOM   864  S  SD  . MET A 1 132 ? -21.017 11.660  -29.243 1.00 67.02  ?  132 MET A SD  1 
ATOM   865  C  CE  . MET A 1 132 ? -21.330 12.847  -27.938 1.00 67.41  ?  132 MET A CE  1 
ATOM   866  N  N   . VAL A 1 133 ? -17.662 7.822   -26.682 1.00 56.47  ?  133 VAL A N   1 
ATOM   867  C  CA  . VAL A 1 133 ? -17.656 6.925   -25.487 1.00 57.90  ?  133 VAL A CA  1 
ATOM   868  C  C   . VAL A 1 133 ? -16.202 6.678   -25.067 1.00 59.01  ?  133 VAL A C   1 
ATOM   869  O  O   . VAL A 1 133 ? -15.945 6.608   -23.851 1.00 59.05  ?  133 VAL A O   1 
ATOM   870  C  CB  . VAL A 1 133 ? -18.427 5.615   -25.743 1.00 59.37  ?  133 VAL A CB  1 
ATOM   871  C  CG1 . VAL A 1 133 ? -18.212 4.588   -24.639 1.00 58.85  ?  133 VAL A CG1 1 
ATOM   872  C  CG2 . VAL A 1 133 ? -19.915 5.875   -25.930 1.00 59.46  ?  133 VAL A CG2 1 
ATOM   873  N  N   . ASP A 1 134 ? -15.285 6.577   -26.033 1.00 61.54  ?  134 ASP A N   1 
ATOM   874  C  CA  . ASP A 1 134 ? -13.828 6.406   -25.773 1.00 64.37  ?  134 ASP A CA  1 
ATOM   875  C  C   . ASP A 1 134 ? -13.314 7.566   -24.916 1.00 62.58  ?  134 ASP A C   1 
ATOM   876  O  O   . ASP A 1 134 ? -12.479 7.315   -24.030 1.00 65.13  ?  134 ASP A O   1 
ATOM   877  C  CB  . ASP A 1 134 ? -13.024 6.303   -27.071 1.00 66.03  ?  134 ASP A CB  1 
ATOM   878  C  CG  . ASP A 1 134 ? -12.919 4.888   -27.613 1.00 70.70  ?  134 ASP A CG  1 
ATOM   879  O  OD1 . ASP A 1 134 ? -13.204 3.937   -26.850 1.00 72.01  ?  134 ASP A OD1 1 
ATOM   880  O  OD2 . ASP A 1 134 ? -12.552 4.748   -28.796 1.00 78.44  ?  134 ASP A OD2 1 
ATOM   881  N  N   . ARG A 1 135 ? -13.805 8.782   -25.162 1.00 60.53  ?  135 ARG A N   1 
ATOM   882  C  CA  . ARG A 1 135 ? -13.264 10.019  -24.538 1.00 59.90  ?  135 ARG A CA  1 
ATOM   883  C  C   . ARG A 1 135 ? -13.787 10.186  -23.105 1.00 58.96  ?  135 ARG A C   1 
ATOM   884  O  O   . ARG A 1 135 ? -13.216 11.026  -22.388 1.00 63.45  ?  135 ARG A O   1 
ATOM   885  C  CB  . ARG A 1 135 ? -13.588 11.228  -25.419 1.00 60.24  ?  135 ARG A CB  1 
ATOM   886  C  CG  . ARG A 1 135 ? -12.771 11.254  -26.703 1.00 60.98  ?  135 ARG A CG  1 
ATOM   887  C  CD  . ARG A 1 135 ? -13.033 12.466  -27.572 1.00 61.57  ?  135 ARG A CD  1 
ATOM   888  N  NE  . ARG A 1 135 ? -12.611 13.698  -26.927 1.00 61.68  ?  135 ARG A NE  1 
ATOM   889  C  CZ  . ARG A 1 135 ? -12.820 14.917  -27.409 1.00 65.28  ?  135 ARG A CZ  1 
ATOM   890  N  NH1 . ARG A 1 135 ? -13.451 15.083  -28.560 1.00 68.37  ?  135 ARG A NH1 1 
ATOM   891  N  NH2 . ARG A 1 135 ? -12.408 15.974  -26.731 1.00 66.80  ?  135 ARG A NH2 1 
ATOM   892  N  N   . ILE A 1 136 ? -14.804 9.422   -22.689 1.00 57.09  ?  136 ILE A N   1 
ATOM   893  C  CA  . ILE A 1 136 ? -15.387 9.522   -21.314 1.00 56.10  ?  136 ILE A CA  1 
ATOM   894  C  C   . ILE A 1 136 ? -15.029 8.285   -20.483 1.00 55.95  ?  136 ILE A C   1 
ATOM   895  O  O   . ILE A 1 136 ? -15.039 8.412   -19.252 1.00 56.63  ?  136 ILE A O   1 
ATOM   896  C  CB  . ILE A 1 136 ? -16.913 9.763   -21.338 1.00 52.86  ?  136 ILE A CB  1 
ATOM   897  C  CG1 . ILE A 1 136 ? -17.697 8.555   -21.859 1.00 53.62  ?  136 ILE A CG1 1 
ATOM   898  C  CG2 . ILE A 1 136 ? -17.247 11.026  -22.111 1.00 51.85  ?  136 ILE A CG2 1 
ATOM   899  C  CD1 . ILE A 1 136 ? -19.150 8.536   -21.433 1.00 53.76  ?  136 ILE A CD1 1 
ATOM   900  N  N   . ARG A 1 137 ? -14.742 7.137   -21.104 1.00 60.12  ?  137 ARG A N   1 
ATOM   901  C  CA  . ARG A 1 137 ? -14.639 5.848   -20.359 1.00 67.24  ?  137 ARG A CA  1 
ATOM   902  C  C   . ARG A 1 137 ? -13.361 5.787   -19.510 1.00 63.77  ?  137 ARG A C   1 
ATOM   903  O  O   . ARG A 1 137 ? -13.275 4.869   -18.678 1.00 64.89  ?  137 ARG A O   1 
ATOM   904  C  CB  . ARG A 1 137 ? -14.758 4.644   -21.297 1.00 75.98  ?  137 ARG A CB  1 
ATOM   905  C  CG  . ARG A 1 137 ? -13.648 4.500   -22.325 1.00 85.90  ?  137 ARG A CG  1 
ATOM   906  C  CD  . ARG A 1 137 ? -13.893 3.251   -23.153 1.00 95.26  ?  137 ARG A CD  1 
ATOM   907  N  NE  . ARG A 1 137 ? -13.589 2.051   -22.384 1.00 100.16 ?  137 ARG A NE  1 
ATOM   908  C  CZ  . ARG A 1 137 ? -12.364 1.577   -22.171 1.00 104.60 ?  137 ARG A CZ  1 
ATOM   909  N  NH1 . ARG A 1 137 ? -11.306 2.193   -22.678 1.00 106.59 ?  137 ARG A NH1 1 
ATOM   910  N  NH2 . ARG A 1 137 ? -12.199 0.482   -21.448 1.00 105.00 ?  137 ARG A NH2 1 
ATOM   911  N  N   . GLU A 1 138 ? -12.428 6.729   -19.681 1.00 63.03  ?  138 GLU A N   1 
ATOM   912  C  CA  . GLU A 1 138 ? -11.164 6.804   -18.896 1.00 60.67  ?  138 GLU A CA  1 
ATOM   913  C  C   . GLU A 1 138 ? -11.284 7.821   -17.749 1.00 58.71  ?  138 GLU A C   1 
ATOM   914  O  O   . GLU A 1 138 ? -10.291 7.985   -17.017 1.00 59.25  ?  138 GLU A O   1 
ATOM   915  C  CB  . GLU A 1 138 ? -10.002 7.164   -19.821 1.00 62.88  ?  138 GLU A CB  1 
ATOM   916  N  N   . ALA A 1 139 ? -12.440 8.476   -17.589 1.00 57.72  ?  139 ALA A N   1 
ATOM   917  C  CA  . ALA A 1 139 ? -12.724 9.420   -16.477 1.00 57.62  ?  139 ALA A CA  1 
ATOM   918  C  C   . ALA A 1 139 ? -12.620 8.674   -15.142 1.00 58.76  ?  139 ALA A C   1 
ATOM   919  O  O   . ALA A 1 139 ? -13.192 7.573   -15.037 1.00 59.20  ?  139 ALA A O   1 
ATOM   920  C  CB  . ALA A 1 139 ? -14.083 10.051  -16.645 1.00 56.66  ?  139 ALA A CB  1 
ATOM   921  N  N   . ASP A 1 140 ? -11.907 9.253   -14.169 1.00 62.34  ?  140 ASP A N   1 
ATOM   922  C  CA  . ASP A 1 140 ? -11.548 8.594   -12.882 1.00 62.53  ?  140 ASP A CA  1 
ATOM   923  C  C   . ASP A 1 140 ? -12.330 9.228   -11.726 1.00 58.33  ?  140 ASP A C   1 
ATOM   924  O  O   . ASP A 1 140 ? -12.094 8.823   -10.578 1.00 64.29  ?  140 ASP A O   1 
ATOM   925  C  CB  . ASP A 1 140 ? -10.038 8.648   -12.629 1.00 65.70  ?  140 ASP A CB  1 
ATOM   926  C  CG  . ASP A 1 140 ? -9.461  10.051  -12.515 1.00 73.72  ?  140 ASP A CG  1 
ATOM   927  O  OD1 . ASP A 1 140 ? -10.170 11.024  -12.869 1.00 75.65  ?  140 ASP A OD1 1 
ATOM   928  O  OD2 . ASP A 1 140 ? -8.296  10.161  -12.078 1.00 82.05  ?  140 ASP A OD2 1 
ATOM   929  N  N   . SER A 1 141 ? -13.230 10.169  -12.018 1.00 53.92  ?  141 SER A N   1 
ATOM   930  C  CA  . SER A 1 141 ? -14.080 10.847  -10.999 1.00 53.47  ?  141 SER A CA  1 
ATOM   931  C  C   . SER A 1 141 ? -15.382 11.316  -11.650 1.00 51.83  ?  141 SER A C   1 
ATOM   932  O  O   . SER A 1 141 ? -15.380 11.540  -12.870 1.00 50.91  ?  141 SER A O   1 
ATOM   933  C  CB  . SER A 1 141 ? -13.358 11.998  -10.341 1.00 55.21  ?  141 SER A CB  1 
ATOM   934  O  OG  . SER A 1 141 ? -13.337 13.141  -11.185 1.00 56.39  ?  141 SER A OG  1 
ATOM   935  N  N   . VAL A 1 142 ? -16.444 11.467  -10.856 1.00 51.84  ?  142 VAL A N   1 
ATOM   936  C  CA  . VAL A 1 142 ? -17.753 12.002  -11.330 1.00 53.89  ?  142 VAL A CA  1 
ATOM   937  C  C   . VAL A 1 142 ? -17.498 13.381  -11.946 1.00 55.04  ?  142 VAL A C   1 
ATOM   938  O  O   . VAL A 1 142 ? -17.968 13.623  -13.068 1.00 54.66  ?  142 VAL A O   1 
ATOM   939  C  CB  . VAL A 1 142 ? -18.791 12.079  -10.196 1.00 53.01  ?  142 VAL A CB  1 
ATOM   940  C  CG1 . VAL A 1 142 ? -20.061 12.787  -10.645 1.00 52.43  ?  142 VAL A CG1 1 
ATOM   941  C  CG2 . VAL A 1 142 ? -19.112 10.702  -9.638  1.00 53.18  ?  142 VAL A CG2 1 
ATOM   942  N  N   . GLU A 1 143 ? -16.745 14.226  -11.239 1.00 57.99  ?  143 GLU A N   1 
ATOM   943  C  CA  . GLU A 1 143 ? -16.465 15.637  -11.624 1.00 59.30  ?  143 GLU A CA  1 
ATOM   944  C  C   . GLU A 1 143 ? -15.806 15.654  -13.010 1.00 54.19  ?  143 GLU A C   1 
ATOM   945  O  O   . GLU A 1 143 ? -16.205 16.482  -13.844 1.00 53.74  ?  143 GLU A O   1 
ATOM   946  C  CB  . GLU A 1 143 ? -15.603 16.318  -10.558 1.00 67.72  ?  143 GLU A CB  1 
ATOM   947  C  CG  . GLU A 1 143 ? -16.303 16.480  -9.209  1.00 77.91  ?  143 GLU A CG  1 
ATOM   948  C  CD  . GLU A 1 143 ? -16.256 15.295  -8.245  1.00 84.96  ?  143 GLU A CD  1 
ATOM   949  O  OE1 . GLU A 1 143 ? -15.291 14.498  -8.311  1.00 86.22  ?  143 GLU A OE1 1 
ATOM   950  O  OE2 . GLU A 1 143 ? -17.187 15.172  -7.418  1.00 88.74  ?  143 GLU A OE2 1 
ATOM   951  N  N   . SER A 1 144 ? -14.852 14.753  -13.252 1.00 50.20  ?  144 SER A N   1 
ATOM   952  C  CA  . SER A 1 144 ? -14.111 14.662  -14.541 1.00 48.41  ?  144 SER A CA  1 
ATOM   953  C  C   . SER A 1 144 ? -15.053 14.215  -15.666 1.00 49.29  ?  144 SER A C   1 
ATOM   954  O  O   . SER A 1 144 ? -14.949 14.765  -16.777 1.00 53.55  ?  144 SER A O   1 
ATOM   955  C  CB  . SER A 1 144 ? -12.923 13.752  -14.438 1.00 45.88  ?  144 SER A CB  1 
ATOM   956  O  OG  . SER A 1 144 ? -12.120 13.847  -15.605 1.00 43.54  ?  144 SER A OG  1 
ATOM   957  N  N   . LEU A 1 145 ? -15.932 13.250  -15.391 1.00 46.94  ?  145 LEU A N   1 
ATOM   958  C  CA  . LEU A 1 145 ? -16.914 12.725  -16.376 1.00 47.50  ?  145 LEU A CA  1 
ATOM   959  C  C   . LEU A 1 145 ? -17.906 13.833  -16.748 1.00 47.55  ?  145 LEU A C   1 
ATOM   960  O  O   . LEU A 1 145 ? -18.164 14.014  -17.950 1.00 46.30  ?  145 LEU A O   1 
ATOM   961  C  CB  . LEU A 1 145 ? -17.642 11.523  -15.768 1.00 46.33  ?  145 LEU A CB  1 
ATOM   962  C  CG  . LEU A 1 145 ? -18.699 10.882  -16.663 1.00 46.02  ?  145 LEU A CG  1 
ATOM   963  C  CD1 . LEU A 1 145 ? -18.058 10.305  -17.915 1.00 46.10  ?  145 LEU A CD1 1 
ATOM   964  C  CD2 . LEU A 1 145 ? -19.471 9.809   -15.915 1.00 46.21  ?  145 LEU A CD2 1 
ATOM   965  N  N   . ILE A 1 146 ? -18.433 14.527  -15.733 1.00 49.94  ?  146 ILE A N   1 
ATOM   966  C  CA  . ILE A 1 146 ? -19.492 15.578  -15.834 1.00 51.00  ?  146 ILE A CA  1 
ATOM   967  C  C   . ILE A 1 146 ? -18.958 16.770  -16.642 1.00 50.64  ?  146 ILE A C   1 
ATOM   968  O  O   . ILE A 1 146 ? -19.645 17.204  -17.584 1.00 50.33  ?  146 ILE A O   1 
ATOM   969  C  CB  . ILE A 1 146 ? -19.951 15.993  -14.417 1.00 54.18  ?  146 ILE A CB  1 
ATOM   970  C  CG1 . ILE A 1 146 ? -20.697 14.870  -13.691 1.00 57.74  ?  146 ILE A CG1 1 
ATOM   971  C  CG2 . ILE A 1 146 ? -20.772 17.268  -14.443 1.00 56.15  ?  146 ILE A CG2 1 
ATOM   972  C  CD1 . ILE A 1 146 ? -21.922 14.367  -14.408 1.00 59.70  ?  146 ILE A CD1 1 
ATOM   973  N  N   . SER A 1 147 ? -17.770 17.267  -16.290 1.00 49.26  ?  147 SER A N   1 
ATOM   974  C  CA  A SER A 1 147 ? -17.174 18.494  -16.887 0.50 48.56  ?  147 SER A CA  1 
ATOM   975  C  CA  B SER A 1 147 ? -17.158 18.488  -16.884 0.50 48.98  ?  147 SER A CA  1 
ATOM   976  C  C   . SER A 1 147 ? -16.834 18.261  -18.365 1.00 48.37  ?  147 SER A C   1 
ATOM   977  O  O   . SER A 1 147 ? -17.065 19.184  -19.167 1.00 51.15  ?  147 SER A O   1 
ATOM   978  C  CB  A SER A 1 147 ? -15.965 18.949  -16.119 0.50 47.29  ?  147 SER A CB  1 
ATOM   979  C  CB  B SER A 1 147 ? -15.927 18.901  -16.124 0.50 48.17  ?  147 SER A CB  1 
ATOM   980  O  OG  A SER A 1 147 ? -14.925 17.992  -16.213 0.50 47.34  ?  147 SER A OG  1 
ATOM   981  O  OG  B SER A 1 147 ? -16.246 19.176  -14.769 0.50 49.34  ?  147 SER A OG  1 
ATOM   982  N  N   . ARG A 1 148 ? -16.302 17.086  -18.695 1.00 47.93  ?  148 ARG A N   1 
ATOM   983  C  CA  . ARG A 1 148 ? -15.845 16.775  -20.078 1.00 49.11  ?  148 ARG A CA  1 
ATOM   984  C  C   . ARG A 1 148 ? -17.046 16.483  -20.982 1.00 49.01  ?  148 ARG A C   1 
ATOM   985  O  O   . ARG A 1 148 ? -16.917 16.717  -22.191 1.00 52.17  ?  148 ARG A O   1 
ATOM   986  C  CB  . ARG A 1 148 ? -14.861 15.603  -20.084 1.00 49.69  ?  148 ARG A CB  1 
ATOM   987  C  CG  . ARG A 1 148 ? -15.511 14.229  -19.998 1.00 50.81  ?  148 ARG A CG  1 
ATOM   988  C  CD  . ARG A 1 148 ? -14.481 13.121  -20.054 1.00 51.04  ?  148 ARG A CD  1 
ATOM   989  N  NE  . ARG A 1 148 ? -13.480 13.260  -19.008 1.00 51.67  ?  148 ARG A NE  1 
ATOM   990  C  CZ  . ARG A 1 148 ? -12.343 12.578  -18.944 1.00 51.76  ?  148 ARG A CZ  1 
ATOM   991  N  NH1 . ARG A 1 148 ? -12.037 11.694  -19.878 1.00 51.74  ?  148 ARG A NH1 1 
ATOM   992  N  NH2 . ARG A 1 148 ? -11.510 12.789  -17.941 1.00 52.87  ?  148 ARG A NH2 1 
ATOM   993  N  N   . THR A 1 149 ? -18.154 15.981  -20.427 1.00 49.24  ?  149 THR A N   1 
ATOM   994  C  CA  . THR A 1 149 ? -19.313 15.487  -21.226 1.00 49.96  ?  149 THR A CA  1 
ATOM   995  C  C   . THR A 1 149 ? -20.031 16.668  -21.900 1.00 50.32  ?  149 THR A C   1 
ATOM   996  O  O   . THR A 1 149 ? -20.358 16.543  -23.095 1.00 49.00  ?  149 THR A O   1 
ATOM   997  C  CB  . THR A 1 149 ? -20.239 14.614  -20.374 1.00 48.90  ?  149 THR A CB  1 
ATOM   998  O  OG1 . THR A 1 149 ? -19.569 13.372  -20.162 1.00 47.47  ?  149 THR A OG1 1 
ATOM   999  C  CG2 . THR A 1 149 ? -21.577 14.340  -21.023 1.00 50.33  ?  149 THR A CG2 1 
ATOM   1000 N  N   . THR A 1 150 ? -20.280 17.763  -21.176 1.00 50.78  ?  150 THR A N   1 
ATOM   1001 C  CA  . THR A 1 150 ? -20.940 18.975  -21.737 1.00 52.39  ?  150 THR A CA  1 
ATOM   1002 C  C   . THR A 1 150 ? -20.078 19.521  -22.876 1.00 53.06  ?  150 THR A C   1 
ATOM   1003 O  O   . THR A 1 150 ? -20.613 19.770  -23.969 1.00 55.28  ?  150 THR A O   1 
ATOM   1004 C  CB  . THR A 1 150 ? -21.192 20.045  -20.667 1.00 53.39  ?  150 THR A CB  1 
ATOM   1005 O  OG1 . THR A 1 150 ? -20.020 20.201  -19.868 1.00 54.16  ?  150 THR A OG1 1 
ATOM   1006 C  CG2 . THR A 1 150 ? -22.367 19.701  -19.780 1.00 53.75  ?  150 THR A CG2 1 
ATOM   1007 N  N   . ARG A 1 151 ? -18.789 19.700  -22.596 1.00 54.62  ?  151 ARG A N   1 
ATOM   1008 C  CA  . ARG A 1 151 ? -17.762 20.164  -23.568 1.00 55.39  ?  151 ARG A CA  1 
ATOM   1009 C  C   . ARG A 1 151 ? -17.783 19.261  -24.809 1.00 54.33  ?  151 ARG A C   1 
ATOM   1010 O  O   . ARG A 1 151 ? -17.829 19.786  -25.933 1.00 56.43  ?  151 ARG A O   1 
ATOM   1011 C  CB  . ARG A 1 151 ? -16.402 20.147  -22.867 1.00 58.58  ?  151 ARG A CB  1 
ATOM   1012 C  CG  . ARG A 1 151 ? -15.440 21.243  -23.291 1.00 61.52  ?  151 ARG A CG  1 
ATOM   1013 C  CD  . ARG A 1 151 ? -14.089 21.029  -22.630 1.00 62.13  ?  151 ARG A CD  1 
ATOM   1014 N  NE  . ARG A 1 151 ? -14.165 21.161  -21.177 1.00 60.68  ?  151 ARG A NE  1 
ATOM   1015 C  CZ  . ARG A 1 151 ? -13.752 20.259  -20.286 1.00 59.08  ?  151 ARG A CZ  1 
ATOM   1016 N  NH1 . ARG A 1 151 ? -13.876 20.522  -18.997 1.00 61.44  ?  151 ARG A NH1 1 
ATOM   1017 N  NH2 . ARG A 1 151 ? -13.202 19.116  -20.662 1.00 57.23  ?  151 ARG A NH2 1 
ATOM   1018 N  N   . LEU A 1 152 ? -17.774 17.945  -24.598 1.00 56.45  ?  152 LEU A N   1 
ATOM   1019 C  CA  . LEU A 1 152 ? -17.703 16.906  -25.664 1.00 57.79  ?  152 LEU A CA  1 
ATOM   1020 C  C   . LEU A 1 152 ? -18.979 16.918  -26.512 1.00 55.27  ?  152 LEU A C   1 
ATOM   1021 O  O   . LEU A 1 152 ? -18.859 16.867  -27.743 1.00 55.00  ?  152 LEU A O   1 
ATOM   1022 C  CB  . LEU A 1 152 ? -17.510 15.535  -25.008 1.00 60.34  ?  152 LEU A CB  1 
ATOM   1023 C  CG  . LEU A 1 152 ? -17.383 14.355  -25.969 1.00 62.91  ?  152 LEU A CG  1 
ATOM   1024 C  CD1 . LEU A 1 152 ? -16.086 14.445  -26.759 1.00 65.38  ?  152 LEU A CD1 1 
ATOM   1025 C  CD2 . LEU A 1 152 ? -17.460 13.036  -25.218 1.00 62.35  ?  152 LEU A CD2 1 
ATOM   1026 N  N   . VAL A 1 153 ? -20.152 16.930  -25.874 1.00 55.24  ?  153 VAL A N   1 
ATOM   1027 C  CA  . VAL A 1 153 ? -21.475 16.875  -26.569 1.00 54.66  ?  153 VAL A CA  1 
ATOM   1028 C  C   . VAL A 1 153 ? -21.645 18.154  -27.399 1.00 54.48  ?  153 VAL A C   1 
ATOM   1029 O  O   . VAL A 1 153 ? -22.131 18.055  -28.545 1.00 52.96  ?  153 VAL A O   1 
ATOM   1030 C  CB  . VAL A 1 153 ? -22.634 16.662  -25.576 1.00 54.10  ?  153 VAL A CB  1 
ATOM   1031 C  CG1 . VAL A 1 153 ? -23.994 16.910  -26.213 1.00 54.59  ?  153 VAL A CG1 1 
ATOM   1032 C  CG2 . VAL A 1 153 ? -22.586 15.270  -24.964 1.00 53.78  ?  153 VAL A CG2 1 
ATOM   1033 N  N   . LYS A 1 154 ? -21.241 19.303  -26.853 1.00 54.63  ?  154 LYS A N   1 
ATOM   1034 C  CA  . LYS A 1 154 ? -21.303 20.610  -27.561 1.00 56.18  ?  154 LYS A CA  1 
ATOM   1035 C  C   . LYS A 1 154 ? -20.466 20.539  -28.844 1.00 55.95  ?  154 LYS A C   1 
ATOM   1036 O  O   . LYS A 1 154 ? -20.985 20.929  -29.898 1.00 54.53  ?  154 LYS A O   1 
ATOM   1037 C  CB  . LYS A 1 154 ? -20.813 21.759  -26.679 1.00 57.49  ?  154 LYS A CB  1 
ATOM   1038 C  CG  . LYS A 1 154 ? -20.802 23.107  -27.385 1.00 60.15  ?  154 LYS A CG  1 
ATOM   1039 C  CD  . LYS A 1 154 ? -20.736 24.299  -26.467 1.00 62.49  ?  154 LYS A CD  1 
ATOM   1040 C  CE  . LYS A 1 154 ? -21.089 25.591  -27.173 1.00 64.43  ?  154 LYS A CE  1 
ATOM   1041 N  NZ  . LYS A 1 154 ? -20.236 25.828  -28.361 1.00 66.61  ?  154 LYS A NZ  1 
ATOM   1042 N  N   . ALA A 1 155 ? -19.220 20.072  -28.748 1.00 57.75  ?  155 ALA A N   1 
ATOM   1043 C  CA  . ALA A 1 155 ? -18.267 19.967  -29.880 1.00 57.72  ?  155 ALA A CA  1 
ATOM   1044 C  C   . ALA A 1 155 ? -18.817 19.023  -30.956 1.00 58.05  ?  155 ALA A C   1 
ATOM   1045 O  O   . ALA A 1 155 ? -18.654 19.344  -32.143 1.00 63.04  ?  155 ALA A O   1 
ATOM   1046 C  CB  . ALA A 1 155 ? -16.919 19.499  -29.392 1.00 57.37  ?  155 ALA A CB  1 
ATOM   1047 N  N   . THR A 1 156 ? -19.439 17.907  -30.556 1.00 58.55  ?  156 THR A N   1 
ATOM   1048 C  CA  . THR A 1 156 ? -19.838 16.802  -31.479 1.00 59.74  ?  156 THR A CA  1 
ATOM   1049 C  C   . THR A 1 156 ? -21.199 17.092  -32.127 1.00 60.29  ?  156 THR A C   1 
ATOM   1050 O  O   . THR A 1 156 ? -21.316 16.869  -33.344 1.00 61.51  ?  156 THR A O   1 
ATOM   1051 C  CB  . THR A 1 156 ? -19.845 15.444  -30.764 1.00 60.52  ?  156 THR A CB  1 
ATOM   1052 O  OG1 . THR A 1 156 ? -18.576 15.251  -30.140 1.00 59.30  ?  156 THR A OG1 1 
ATOM   1053 C  CG2 . THR A 1 156 ? -20.105 14.281  -31.696 1.00 61.32  ?  156 THR A CG2 1 
ATOM   1054 N  N   . LEU A 1 157 ? -22.191 17.545  -31.355 1.00 60.59  ?  157 LEU A N   1 
ATOM   1055 C  CA  . LEU A 1 157 ? -23.579 17.770  -31.850 1.00 61.20  ?  157 LEU A CA  1 
ATOM   1056 C  C   . LEU A 1 157 ? -23.828 19.259  -32.123 1.00 60.34  ?  157 LEU A C   1 
ATOM   1057 O  O   . LEU A 1 157 ? -24.938 19.592  -32.564 1.00 63.30  ?  157 LEU A O   1 
ATOM   1058 C  CB  . LEU A 1 157 ? -24.573 17.220  -30.825 1.00 61.72  ?  157 LEU A CB  1 
ATOM   1059 C  CG  . LEU A 1 157 ? -24.364 15.761  -30.425 1.00 62.82  ?  157 LEU A CG  1 
ATOM   1060 C  CD1 . LEU A 1 157 ? -25.537 15.263  -29.600 1.00 65.23  ?  157 LEU A CD1 1 
ATOM   1061 C  CD2 . LEU A 1 157 ? -24.161 14.873  -31.643 1.00 64.60  ?  157 LEU A CD2 1 
ATOM   1062 N  N   . GLY A 1 158 ? -22.838 20.117  -31.871 1.00 60.01  ?  158 GLY A N   1 
ATOM   1063 C  CA  . GLY A 1 158 ? -22.852 21.539  -32.267 1.00 60.88  ?  158 GLY A CA  1 
ATOM   1064 C  C   . GLY A 1 158 ? -24.078 22.286  -31.769 1.00 59.61  ?  158 GLY A C   1 
ATOM   1065 O  O   . GLY A 1 158 ? -24.625 23.095  -32.538 1.00 65.05  ?  158 GLY A O   1 
ATOM   1066 N  N   . TYR A 1 159 ? -24.498 22.036  -30.531 1.00 59.07  ?  159 TYR A N   1 
ATOM   1067 C  CA  . TYR A 1 159 ? -25.582 22.798  -29.858 1.00 59.98  ?  159 TYR A CA  1 
ATOM   1068 C  C   . TYR A 1 159 ? -24.970 24.049  -29.218 1.00 61.26  ?  159 TYR A C   1 
ATOM   1069 O  O   . TYR A 1 159 ? -23.777 24.016  -28.850 1.00 62.10  ?  159 TYR A O   1 
ATOM   1070 C  CB  . TYR A 1 159 ? -26.334 21.911  -28.863 1.00 59.40  ?  159 TYR A CB  1 
ATOM   1071 C  CG  . TYR A 1 159 ? -27.459 21.120  -29.479 1.00 58.38  ?  159 TYR A CG  1 
ATOM   1072 C  CD1 . TYR A 1 159 ? -27.227 19.916  -30.123 1.00 56.98  ?  159 TYR A CD1 1 
ATOM   1073 C  CD2 . TYR A 1 159 ? -28.765 21.580  -29.420 1.00 60.70  ?  159 TYR A CD2 1 
ATOM   1074 C  CE1 . TYR A 1 159 ? -28.262 19.190  -30.691 1.00 57.67  ?  159 TYR A CE1 1 
ATOM   1075 C  CE2 . TYR A 1 159 ? -29.812 20.865  -29.978 1.00 59.93  ?  159 TYR A CE2 1 
ATOM   1076 C  CZ  . TYR A 1 159 ? -29.561 19.665  -30.618 1.00 58.43  ?  159 TYR A CZ  1 
ATOM   1077 O  OH  . TYR A 1 159 ? -30.597 18.973  -31.174 1.00 59.13  ?  159 TYR A OH  1 
ATOM   1078 N  N   . ASP A 1 160 ? -25.764 25.118  -29.108 1.00 61.34  ?  160 ASP A N   1 
ATOM   1079 C  CA  . ASP A 1 160 ? -25.317 26.450  -28.614 1.00 61.52  ?  160 ASP A CA  1 
ATOM   1080 C  C   . ASP A 1 160 ? -25.027 26.358  -27.114 1.00 58.45  ?  160 ASP A C   1 
ATOM   1081 O  O   . ASP A 1 160 ? -24.081 27.017  -26.657 1.00 58.54  ?  160 ASP A O   1 
ATOM   1082 C  CB  . ASP A 1 160 ? -26.355 27.537  -28.904 1.00 62.64  ?  160 ASP A CB  1 
ATOM   1083 C  CG  . ASP A 1 160 ? -26.471 27.902  -30.373 1.00 61.84  ?  160 ASP A CG  1 
ATOM   1084 O  OD1 . ASP A 1 160 ? -25.490 27.695  -31.109 1.00 63.13  ?  160 ASP A OD1 1 
ATOM   1085 O  OD2 . ASP A 1 160 ? -27.540 28.392  -30.764 1.00 63.91  ?  160 ASP A OD2 1 
ATOM   1086 N  N   . ARG A 1 161 ? -25.835 25.588  -26.385 1.00 57.74  ?  161 ARG A N   1 
ATOM   1087 C  CA  . ARG A 1 161 ? -25.627 25.324  -24.936 1.00 58.03  ?  161 ARG A CA  1 
ATOM   1088 C  C   . ARG A 1 161 ? -25.872 23.838  -24.650 1.00 56.74  ?  161 ARG A C   1 
ATOM   1089 O  O   . ARG A 1 161 ? -26.807 23.265  -25.240 1.00 54.41  ?  161 ARG A O   1 
ATOM   1090 C  CB  . ARG A 1 161 ? -26.547 26.209  -24.093 1.00 58.53  ?  161 ARG A CB  1 
ATOM   1091 C  CG  . ARG A 1 161 ? -26.353 26.045  -22.594 1.00 61.59  ?  161 ARG A CG  1 
ATOM   1092 C  CD  . ARG A 1 161 ? -27.450 26.694  -21.782 1.00 63.68  ?  161 ARG A CD  1 
ATOM   1093 N  NE  . ARG A 1 161 ? -27.253 28.130  -21.663 1.00 65.32  ?  161 ARG A NE  1 
ATOM   1094 C  CZ  . ARG A 1 161 ? -28.069 29.060  -22.148 1.00 70.81  ?  161 ARG A CZ  1 
ATOM   1095 N  NH1 . ARG A 1 161 ? -29.180 28.727  -22.793 1.00 71.84  ?  161 ARG A NH1 1 
ATOM   1096 N  NH2 . ARG A 1 161 ? -27.772 30.335  -21.967 1.00 72.49  ?  161 ARG A NH2 1 
ATOM   1097 N  N   . VAL A 1 162 ? -25.033 23.247  -23.796 1.00 55.37  ?  162 VAL A N   1 
ATOM   1098 C  CA  . VAL A 1 162 ? -25.218 21.883  -23.222 1.00 55.80  ?  162 VAL A CA  1 
ATOM   1099 C  C   . VAL A 1 162 ? -25.090 22.012  -21.704 1.00 54.81  ?  162 VAL A C   1 
ATOM   1100 O  O   . VAL A 1 162 ? -24.043 22.491  -21.239 1.00 54.16  ?  162 VAL A O   1 
ATOM   1101 C  CB  . VAL A 1 162 ? -24.213 20.860  -23.787 1.00 57.34  ?  162 VAL A CB  1 
ATOM   1102 C  CG1 . VAL A 1 162 ? -24.464 19.461  -23.239 1.00 56.19  ?  162 VAL A CG1 1 
ATOM   1103 C  CG2 . VAL A 1 162 ? -24.220 20.841  -25.309 1.00 57.78  ?  162 VAL A CG2 1 
ATOM   1104 N  N   . LEU A 1 163 ? -26.142 21.630  -20.983 1.00 55.44  ?  163 LEU A N   1 
ATOM   1105 C  CA  . LEU A 1 163 ? -26.184 21.597  -19.499 1.00 56.03  ?  163 LEU A CA  1 
ATOM   1106 C  C   . LEU A 1 163 ? -26.278 20.139  -19.055 1.00 56.30  ?  163 LEU A C   1 
ATOM   1107 O  O   . LEU A 1 163 ? -26.829 19.325  -19.823 1.00 57.05  ?  163 LEU A O   1 
ATOM   1108 C  CB  . LEU A 1 163 ? -27.411 22.373  -19.013 1.00 58.62  ?  163 LEU A CB  1 
ATOM   1109 C  CG  . LEU A 1 163 ? -27.497 23.829  -19.464 1.00 59.96  ?  163 LEU A CG  1 
ATOM   1110 C  CD1 . LEU A 1 163 ? -28.919 24.345  -19.346 1.00 60.06  ?  163 LEU A CD1 1 
ATOM   1111 C  CD2 . LEU A 1 163 ? -26.542 24.700  -18.662 1.00 61.42  ?  163 LEU A CD2 1 
ATOM   1112 N  N   . ILE A 1 164 ? -25.766 19.829  -17.863 1.00 56.09  ?  164 ILE A N   1 
ATOM   1113 C  CA  . ILE A 1 164 ? -26.160 18.607  -17.103 1.00 53.52  ?  164 ILE A CA  1 
ATOM   1114 C  C   . ILE A 1 164 ? -26.965 19.071  -15.885 1.00 53.37  ?  164 ILE A C   1 
ATOM   1115 O  O   . ILE A 1 164 ? -26.447 19.878  -15.088 1.00 50.66  ?  164 ILE A O   1 
ATOM   1116 C  CB  . ILE A 1 164 ? -24.954 17.712  -16.754 1.00 52.78  ?  164 ILE A CB  1 
ATOM   1117 C  CG1 . ILE A 1 164 ? -24.329 17.131  -18.026 1.00 52.27  ?  164 ILE A CG1 1 
ATOM   1118 C  CG2 . ILE A 1 164 ? -25.357 16.611  -15.781 1.00 53.59  ?  164 ILE A CG2 1 
ATOM   1119 C  CD1 . ILE A 1 164 ? -23.032 16.389  -17.810 1.00 52.08  ?  164 ILE A CD1 1 
ATOM   1120 N  N   . TYR A 1 165 ? -28.224 18.631  -15.841 1.00 55.74  ?  165 TYR A N   1 
ATOM   1121 C  CA  A TYR A 1 165 ? -29.161 18.843  -14.707 0.50 55.66  ?  165 TYR A CA  1 
ATOM   1122 C  CA  B TYR A 1 165 ? -29.201 18.826  -14.739 0.50 56.13  ?  165 TYR A CA  1 
ATOM   1123 C  C   . TYR A 1 165 ? -29.071 17.634  -13.781 1.00 55.53  ?  165 TYR A C   1 
ATOM   1124 O  O   . TYR A 1 165 ? -29.258 16.507  -14.266 1.00 57.48  ?  165 TYR A O   1 
ATOM   1125 C  CB  A TYR A 1 165 ? -30.613 18.989  -15.166 0.50 57.27  ?  165 TYR A CB  1 
ATOM   1126 C  CB  B TYR A 1 165 ? -30.598 18.905  -15.367 0.50 58.35  ?  165 TYR A CB  1 
ATOM   1127 C  CG  A TYR A 1 165 ? -30.888 20.152  -16.080 0.50 57.90  ?  165 TYR A CG  1 
ATOM   1128 C  CG  B TYR A 1 165 ? -31.644 19.735  -14.666 0.50 59.52  ?  165 TYR A CG  1 
ATOM   1129 C  CD1 A TYR A 1 165 ? -30.144 21.317  -16.006 0.50 58.04  ?  165 TYR A CD1 1 
ATOM   1130 C  CD1 B TYR A 1 165 ? -31.542 21.114  -14.592 0.50 59.93  ?  165 TYR A CD1 1 
ATOM   1131 C  CD2 A TYR A 1 165 ? -31.920 20.097  -16.998 0.50 58.26  ?  165 TYR A CD2 1 
ATOM   1132 C  CD2 B TYR A 1 165 ? -32.793 19.144  -14.166 0.50 60.25  ?  165 TYR A CD2 1 
ATOM   1133 C  CE1 A TYR A 1 165 ? -30.403 22.388  -16.843 0.50 59.12  ?  165 TYR A CE1 1 
ATOM   1134 C  CE1 B TYR A 1 165 ? -32.525 21.878  -13.986 0.50 60.98  ?  165 TYR A CE1 1 
ATOM   1135 C  CE2 A TYR A 1 165 ? -32.195 21.161  -17.839 0.50 58.87  ?  165 TYR A CE2 1 
ATOM   1136 C  CE2 B TYR A 1 165 ? -33.786 19.892  -13.560 0.50 60.91  ?  165 TYR A CE2 1 
ATOM   1137 C  CZ  A TYR A 1 165 ? -31.432 22.310  -17.765 0.50 59.29  ?  165 TYR A CZ  1 
ATOM   1138 C  CZ  B TYR A 1 165 ? -33.653 21.265  -13.471 0.50 61.11  ?  165 TYR A CZ  1 
ATOM   1139 O  OH  A TYR A 1 165 ? -31.713 23.354  -18.596 0.50 61.36  ?  165 TYR A OH  1 
ATOM   1140 O  OH  B TYR A 1 165 ? -34.631 21.998  -12.863 0.50 62.52  ?  165 TYR A OH  1 
ATOM   1141 N  N   . ARG A 1 166 ? -28.758 17.871  -12.505 1.00 54.74  ?  166 ARG A N   1 
ATOM   1142 C  CA  . ARG A 1 166 ? -28.737 16.786  -11.482 1.00 54.05  ?  166 ARG A CA  1 
ATOM   1143 C  C   . ARG A 1 166 ? -29.906 17.019  -10.524 1.00 53.76  ?  166 ARG A C   1 
ATOM   1144 O  O   . ARG A 1 166 ? -30.000 18.130  -9.973  1.00 56.64  ?  166 ARG A O   1 
ATOM   1145 C  CB  . ARG A 1 166 ? -27.421 16.734  -10.704 1.00 54.92  ?  166 ARG A CB  1 
ATOM   1146 C  CG  . ARG A 1 166 ? -27.356 15.593  -9.697  1.00 56.56  ?  166 ARG A CG  1 
ATOM   1147 C  CD  . ARG A 1 166 ? -26.145 15.690  -8.797  1.00 57.88  ?  166 ARG A CD  1 
ATOM   1148 N  NE  . ARG A 1 166 ? -26.240 16.825  -7.886  1.00 60.38  ?  166 ARG A NE  1 
ATOM   1149 C  CZ  . ARG A 1 166 ? -25.205 17.452  -7.324  1.00 63.32  ?  166 ARG A CZ  1 
ATOM   1150 N  NH1 . ARG A 1 166 ? -23.961 17.076  -7.574  1.00 65.89  ?  166 ARG A NH1 1 
ATOM   1151 N  NH2 . ARG A 1 166 ? -25.419 18.474  -6.515  1.00 65.73  ?  166 ARG A NH2 1 
ATOM   1152 N  N   . PHE A 1 167 ? -30.755 16.008  -10.337 1.00 52.97  ?  167 PHE A N   1 
ATOM   1153 C  CA  . PHE A 1 167 ? -31.931 16.072  -9.435  1.00 53.15  ?  167 PHE A CA  1 
ATOM   1154 C  C   . PHE A 1 167 ? -31.468 15.907  -7.983  1.00 54.38  ?  167 PHE A C   1 
ATOM   1155 O  O   . PHE A 1 167 ? -30.730 14.951  -7.684  1.00 53.88  ?  167 PHE A O   1 
ATOM   1156 C  CB  . PHE A 1 167 ? -32.972 15.027  -9.835  1.00 53.78  ?  167 PHE A CB  1 
ATOM   1157 C  CG  . PHE A 1 167 ? -33.662 15.317  -11.142 1.00 54.17  ?  167 PHE A CG  1 
ATOM   1158 C  CD1 . PHE A 1 167 ? -34.363 16.498  -11.323 1.00 55.81  ?  167 PHE A CD1 1 
ATOM   1159 C  CD2 . PHE A 1 167 ? -33.621 14.410  -12.188 1.00 55.11  ?  167 PHE A CD2 1 
ATOM   1160 C  CE1 . PHE A 1 167 ? -35.002 16.769  -12.522 1.00 57.74  ?  167 PHE A CE1 1 
ATOM   1161 C  CE2 . PHE A 1 167 ? -34.263 14.683  -13.387 1.00 58.23  ?  167 PHE A CE2 1 
ATOM   1162 C  CZ  . PHE A 1 167 ? -34.953 15.861  -13.552 1.00 57.84  ?  167 PHE A CZ  1 
ATOM   1163 N  N   . GLU A 1 168 ? -31.890 16.833  -7.119  1.00 57.00  ?  168 GLU A N   1 
ATOM   1164 C  CA  . GLU A 1 168 ? -31.706 16.771  -5.644  1.00 59.79  ?  168 GLU A CA  1 
ATOM   1165 C  C   . GLU A 1 168 ? -32.714 15.781  -5.049  1.00 60.61  ?  168 GLU A C   1 
ATOM   1166 O  O   . GLU A 1 168 ? -33.561 15.264  -5.809  1.00 60.44  ?  168 GLU A O   1 
ATOM   1167 C  CB  . GLU A 1 168 ? -31.887 18.161  -5.033  1.00 60.71  ?  168 GLU A CB  1 
ATOM   1168 C  CG  . GLU A 1 168 ? -30.868 19.171  -5.523  1.00 61.87  ?  168 GLU A CG  1 
ATOM   1169 C  CD  . GLU A 1 168 ? -29.438 18.819  -5.159  1.00 63.94  ?  168 GLU A CD  1 
ATOM   1170 O  OE1 . GLU A 1 168 ? -29.143 18.785  -3.949  1.00 64.80  ?  168 GLU A OE1 1 
ATOM   1171 O  OE2 . GLU A 1 168 ? -28.635 18.551  -6.083  1.00 65.05  ?  168 GLU A OE2 1 
ATOM   1172 N  N   . GLU A 1 169 ? -32.622 15.531  -3.739  1.00 64.04  ?  169 GLU A N   1 
ATOM   1173 C  CA  . GLU A 1 169 ? -33.537 14.616  -2.999  1.00 67.49  ?  169 GLU A CA  1 
ATOM   1174 C  C   . GLU A 1 169 ? -34.985 15.098  -3.173  1.00 68.35  ?  169 GLU A C   1 
ATOM   1175 O  O   . GLU A 1 169 ? -35.863 14.245  -3.431  1.00 66.48  ?  169 GLU A O   1 
ATOM   1176 C  CB  . GLU A 1 169 ? -33.141 14.541  -1.521  1.00 68.72  ?  169 GLU A CB  1 
ATOM   1177 N  N   . ASP A 1 170 ? -35.204 16.419  -3.084  1.00 66.33  ?  170 ASP A N   1 
ATOM   1178 C  CA  . ASP A 1 170 ? -36.545 17.071  -3.074  1.00 65.14  ?  170 ASP A CA  1 
ATOM   1179 C  C   . ASP A 1 170 ? -37.110 17.203  -4.495  1.00 62.26  ?  170 ASP A C   1 
ATOM   1180 O  O   . ASP A 1 170 ? -38.202 17.780  -4.632  1.00 65.02  ?  170 ASP A O   1 
ATOM   1181 C  CB  . ASP A 1 170 ? -36.495 18.443  -2.393  1.00 67.76  ?  170 ASP A CB  1 
ATOM   1182 C  CG  . ASP A 1 170 ? -35.534 19.433  -3.029  1.00 72.15  ?  170 ASP A CG  1 
ATOM   1183 O  OD1 . ASP A 1 170 ? -35.047 19.145  -4.133  1.00 75.36  ?  170 ASP A OD1 1 
ATOM   1184 O  OD2 . ASP A 1 170 ? -35.269 20.479  -2.405  1.00 77.64  ?  170 ASP A OD2 1 
ATOM   1185 N  N   . GLY A 1 171 ? -36.397 16.715  -5.514  1.00 61.19  ?  171 GLY A N   1 
ATOM   1186 C  CA  . GLY A 1 171 ? -36.832 16.778  -6.925  1.00 58.59  ?  171 GLY A CA  1 
ATOM   1187 C  C   . GLY A 1 171 ? -36.347 18.037  -7.626  1.00 56.66  ?  171 GLY A C   1 
ATOM   1188 O  O   . GLY A 1 171 ? -36.447 18.090  -8.862  1.00 61.32  ?  171 GLY A O   1 
ATOM   1189 N  N   . ALA A 1 172 ? -35.837 19.021  -6.882  1.00 53.57  ?  172 ALA A N   1 
ATOM   1190 C  CA  . ALA A 1 172 ? -35.211 20.240  -7.444  1.00 52.70  ?  172 ALA A CA  1 
ATOM   1191 C  C   . ALA A 1 172 ? -34.044 19.821  -8.341  1.00 52.81  ?  172 ALA A C   1 
ATOM   1192 O  O   . ALA A 1 172 ? -33.526 18.709  -8.154  1.00 52.36  ?  172 ALA A O   1 
ATOM   1193 C  CB  . ALA A 1 172 ? -34.755 21.165  -6.343  1.00 52.85  ?  172 ALA A CB  1 
ATOM   1194 N  N   . GLY A 1 173 ? -33.663 20.679  -9.288  1.00 53.81  ?  173 GLY A N   1 
ATOM   1195 C  CA  . GLY A 1 173 ? -32.555 20.425  -10.225 1.00 54.90  ?  173 GLY A CA  1 
ATOM   1196 C  C   . GLY A 1 173 ? -31.418 21.403  -10.015 1.00 56.18  ?  173 GLY A C   1 
ATOM   1197 O  O   . GLY A 1 173 ? -31.699 22.600  -9.845  1.00 59.67  ?  173 GLY A O   1 
ATOM   1198 N  N   . LYS A 1 174 ? -30.179 20.908  -10.008 1.00 54.74  ?  174 LYS A N   1 
ATOM   1199 C  CA  . LYS A 1 174 ? -28.962 21.754  -9.995  1.00 54.44  ?  174 LYS A CA  1 
ATOM   1200 C  C   . LYS A 1 174 ? -28.250 21.606  -11.342 1.00 54.07  ?  174 LYS A C   1 
ATOM   1201 O  O   . LYS A 1 174 ? -28.180 20.477  -11.858 1.00 53.66  ?  174 LYS A O   1 
ATOM   1202 C  CB  . LYS A 1 174 ? -28.038 21.379  -8.835  1.00 56.88  ?  174 LYS A CB  1 
ATOM   1203 C  CG  . LYS A 1 174 ? -26.986 22.431  -8.514  1.00 59.41  ?  174 LYS A CG  1 
ATOM   1204 C  CD  . LYS A 1 174 ? -25.928 21.972  -7.546  1.00 62.73  ?  174 LYS A CD  1 
ATOM   1205 C  CE  . LYS A 1 174 ? -24.931 23.064  -7.224  1.00 66.86  ?  174 LYS A CE  1 
ATOM   1206 N  NZ  . LYS A 1 174 ? -23.874 22.581  -6.306  1.00 71.24  ?  174 LYS A NZ  1 
ATOM   1207 N  N   . VAL A 1 175 ? -27.764 22.720  -11.889 1.00 53.53  ?  175 VAL A N   1 
ATOM   1208 C  CA  . VAL A 1 175 ? -26.905 22.758  -13.107 1.00 52.95  ?  175 VAL A CA  1 
ATOM   1209 C  C   . VAL A 1 175 ? -25.463 22.521  -12.648 1.00 52.61  ?  175 VAL A C   1 
ATOM   1210 O  O   . VAL A 1 175 ? -24.871 23.453  -12.070 1.00 55.14  ?  175 VAL A O   1 
ATOM   1211 C  CB  . VAL A 1 175 ? -27.059 24.093  -13.859 1.00 51.15  ?  175 VAL A CB  1 
ATOM   1212 C  CG1 . VAL A 1 175 ? -26.166 24.162  -15.086 1.00 52.01  ?  175 VAL A CG1 1 
ATOM   1213 C  CG2 . VAL A 1 175 ? -28.505 24.351  -14.242 1.00 51.50  ?  175 VAL A CG2 1 
ATOM   1214 N  N   . VAL A 1 176 ? -24.935 21.319  -12.889 1.00 50.80  ?  176 VAL A N   1 
ATOM   1215 C  CA  . VAL A 1 176 ? -23.642 20.845  -12.306 1.00 50.38  ?  176 VAL A CA  1 
ATOM   1216 C  C   . VAL A 1 176 ? -22.512 20.972  -13.336 1.00 52.37  ?  176 VAL A C   1 
ATOM   1217 O  O   . VAL A 1 176 ? -21.340 20.824  -12.928 1.00 55.46  ?  176 VAL A O   1 
ATOM   1218 C  CB  . VAL A 1 176 ? -23.762 19.413  -11.754 1.00 48.97  ?  176 VAL A CB  1 
ATOM   1219 C  CG1 . VAL A 1 176 ? -24.720 19.366  -10.575 1.00 49.60  ?  176 VAL A CG1 1 
ATOM   1220 C  CG2 . VAL A 1 176 ? -24.166 18.401  -12.817 1.00 48.57  ?  176 VAL A CG2 1 
ATOM   1221 N  N   . SER A 1 177 ? -22.834 21.233  -14.608 1.00 51.50  ?  177 SER A N   1 
ATOM   1222 C  CA  . SER A 1 177 ? -21.829 21.621  -15.640 1.00 52.28  ?  177 SER A CA  1 
ATOM   1223 C  C   . SER A 1 177 ? -22.522 22.248  -16.851 1.00 51.72  ?  177 SER A C   1 
ATOM   1224 O  O   . SER A 1 177 ? -23.747 22.065  -17.010 1.00 49.21  ?  177 SER A O   1 
ATOM   1225 C  CB  . SER A 1 177 ? -20.932 20.480  -16.060 1.00 53.39  ?  177 SER A CB  1 
ATOM   1226 O  OG  . SER A 1 177 ? -21.625 19.570  -16.895 1.00 54.42  ?  177 SER A OG  1 
ATOM   1227 N  N   . GLU A 1 178 ? -21.735 22.940  -17.677 1.00 53.03  ?  178 GLU A N   1 
ATOM   1228 C  CA  . GLU A 1 178 ? -22.228 23.812  -18.770 1.00 53.93  ?  178 GLU A CA  1 
ATOM   1229 C  C   . GLU A 1 178 ? -21.109 24.068  -19.782 1.00 53.92  ?  178 GLU A C   1 
ATOM   1230 O  O   . GLU A 1 178 ? -20.007 24.464  -19.369 1.00 55.30  ?  178 GLU A O   1 
ATOM   1231 C  CB  . GLU A 1 178 ? -22.713 25.135  -18.184 1.00 55.93  ?  178 GLU A CB  1 
ATOM   1232 C  CG  . GLU A 1 178 ? -23.182 26.131  -19.225 1.00 57.63  ?  178 GLU A CG  1 
ATOM   1233 C  CD  . GLU A 1 178 ? -23.685 27.425  -18.617 1.00 57.95  ?  178 GLU A CD  1 
ATOM   1234 O  OE1 . GLU A 1 178 ? -22.879 28.107  -17.950 1.00 56.79  ?  178 GLU A OE1 1 
ATOM   1235 O  OE2 . GLU A 1 178 ? -24.884 27.730  -18.788 1.00 58.57  ?  178 GLU A OE2 1 
ATOM   1236 N  N   . ALA A 1 179 ? -21.406 23.841  -21.059 1.00 52.57  ?  179 ALA A N   1 
ATOM   1237 C  CA  . ALA A 1 179 ? -20.640 24.345  -22.219 1.00 53.50  ?  179 ALA A CA  1 
ATOM   1238 C  C   . ALA A 1 179 ? -21.591 25.205  -23.053 1.00 53.21  ?  179 ALA A C   1 
ATOM   1239 O  O   . ALA A 1 179 ? -22.735 24.762  -23.278 1.00 52.16  ?  179 ALA A O   1 
ATOM   1240 C  CB  . ALA A 1 179 ? -20.069 23.195  -23.008 1.00 54.85  ?  179 ALA A CB  1 
ATOM   1241 N  N   . LYS A 1 180 ? -21.155 26.397  -23.462 1.00 53.85  ?  180 LYS A N   1 
ATOM   1242 C  CA  . LYS A 1 180 ? -22.045 27.386  -24.125 1.00 56.05  ?  180 LYS A CA  1 
ATOM   1243 C  C   . LYS A 1 180 ? -21.241 28.307  -25.042 1.00 59.46  ?  180 LYS A C   1 
ATOM   1244 O  O   . LYS A 1 180 ? -20.010 28.419  -24.859 1.00 61.60  ?  180 LYS A O   1 
ATOM   1245 C  CB  . LYS A 1 180 ? -22.805 28.206  -23.077 1.00 57.21  ?  180 LYS A CB  1 
ATOM   1246 C  CG  . LYS A 1 180 ? -21.948 29.069  -22.160 1.00 57.42  ?  180 LYS A CG  1 
ATOM   1247 C  CD  . LYS A 1 180 ? -22.762 30.052  -21.345 1.00 60.23  ?  180 LYS A CD  1 
ATOM   1248 C  CE  . LYS A 1 180 ? -21.924 31.014  -20.527 1.00 62.29  ?  180 LYS A CE  1 
ATOM   1249 N  NZ  . LYS A 1 180 ? -21.070 31.877  -21.377 1.00 64.31  ?  180 LYS A NZ  1 
ATOM   1250 N  N   . GLN A 1 181 ? -21.937 28.935  -25.992 1.00 63.45  ?  181 GLN A N   1 
ATOM   1251 C  CA  . GLN A 1 181 ? -21.430 30.086  -26.780 1.00 65.12  ?  181 GLN A CA  1 
ATOM   1252 C  C   . GLN A 1 181 ? -21.085 31.197  -25.791 1.00 65.21  ?  181 GLN A C   1 
ATOM   1253 O  O   . GLN A 1 181 ? -21.810 31.395  -24.820 1.00 64.23  ?  181 GLN A O   1 
ATOM   1254 C  CB  . GLN A 1 181 ? -22.478 30.531  -27.805 1.00 68.89  ?  181 GLN A CB  1 
ATOM   1255 C  CG  . GLN A 1 181 ? -22.754 29.507  -28.902 1.00 72.94  ?  181 GLN A CG  1 
ATOM   1256 C  CD  . GLN A 1 181 ? -21.522 29.076  -29.664 1.00 75.99  ?  181 GLN A CD  1 
ATOM   1257 O  OE1 . GLN A 1 181 ? -21.331 27.897  -29.950 1.00 76.81  ?  181 GLN A OE1 1 
ATOM   1258 N  NE2 . GLN A 1 181 ? -20.667 30.026  -30.009 1.00 81.05  ?  181 GLN A NE2 1 
ATOM   1259 N  N   . PRO A 1 182 ? -19.979 31.953  -25.987 1.00 67.45  ?  182 PRO A N   1 
ATOM   1260 C  CA  . PRO A 1 182 ? -19.549 32.949  -25.001 1.00 66.79  ?  182 PRO A CA  1 
ATOM   1261 C  C   . PRO A 1 182 ? -20.585 34.055  -24.742 1.00 68.06  ?  182 PRO A C   1 
ATOM   1262 O  O   . PRO A 1 182 ? -20.595 34.596  -23.653 1.00 71.88  ?  182 PRO A O   1 
ATOM   1263 C  CB  . PRO A 1 182 ? -18.276 33.557  -25.614 1.00 65.64  ?  182 PRO A CB  1 
ATOM   1264 C  CG  . PRO A 1 182 ? -17.817 32.546  -26.648 1.00 65.01  ?  182 PRO A CG  1 
ATOM   1265 C  CD  . PRO A 1 182 ? -19.085 31.896  -27.157 1.00 65.89  ?  182 PRO A CD  1 
ATOM   1266 N  N   . GLU A 1 183 ? -21.416 34.357  -25.744 1.00 69.69  ?  183 GLU A N   1 
ATOM   1267 C  CA  . GLU A 1 183 ? -22.429 35.451  -25.716 1.00 71.59  ?  183 GLU A CA  1 
ATOM   1268 C  C   . GLU A 1 183 ? -23.589 35.089  -24.776 1.00 68.59  ?  183 GLU A C   1 
ATOM   1269 O  O   . GLU A 1 183 ? -24.147 36.020  -24.162 1.00 67.18  ?  183 GLU A O   1 
ATOM   1270 C  CB  . GLU A 1 183 ? -22.935 35.772  -27.127 1.00 76.79  ?  183 GLU A CB  1 
ATOM   1271 C  CG  . GLU A 1 183 ? -23.245 34.557  -27.993 1.00 83.32  ?  183 GLU A CG  1 
ATOM   1272 C  CD  . GLU A 1 183 ? -22.121 34.080  -28.907 1.00 92.42  ?  183 GLU A CD  1 
ATOM   1273 O  OE1 . GLU A 1 183 ? -20.946 34.430  -28.649 1.00 93.67  ?  183 GLU A OE1 1 
ATOM   1274 O  OE2 . GLU A 1 183 ? -22.423 33.349  -29.879 1.00 98.63  ?  183 GLU A OE2 1 
ATOM   1275 N  N   . LEU A 1 184 ? -23.937 33.801  -24.666 1.00 67.43  ?  184 LEU A N   1 
ATOM   1276 C  CA  . LEU A 1 184 ? -25.094 33.300  -23.866 1.00 66.84  ?  184 LEU A CA  1 
ATOM   1277 C  C   . LEU A 1 184 ? -24.811 33.430  -22.365 1.00 64.93  ?  184 LEU A C   1 
ATOM   1278 O  O   . LEU A 1 184 ? -23.628 33.388  -21.972 1.00 60.68  ?  184 LEU A O   1 
ATOM   1279 C  CB  . LEU A 1 184 ? -25.376 31.836  -24.220 1.00 69.16  ?  184 LEU A CB  1 
ATOM   1280 C  CG  . LEU A 1 184 ? -25.970 31.581  -25.603 1.00 71.54  ?  184 LEU A CG  1 
ATOM   1281 C  CD1 . LEU A 1 184 ? -26.065 30.088  -25.872 1.00 70.67  ?  184 LEU A CD1 1 
ATOM   1282 C  CD2 . LEU A 1 184 ? -27.337 32.234  -25.746 1.00 72.26  ?  184 LEU A CD2 1 
ATOM   1283 N  N   . GLU A 1 185 ? -25.875 33.557  -21.565 1.00 64.97  ?  185 GLU A N   1 
ATOM   1284 C  CA  . GLU A 1 185 ? -25.808 33.666  -20.082 1.00 66.27  ?  185 GLU A CA  1 
ATOM   1285 C  C   . GLU A 1 185 ? -25.596 32.265  -19.496 1.00 64.94  ?  185 GLU A C   1 
ATOM   1286 O  O   . GLU A 1 185 ? -26.093 31.285  -20.094 1.00 65.39  ?  185 GLU A O   1 
ATOM   1287 C  CB  . GLU A 1 185 ? -27.049 34.372  -19.522 1.00 70.39  ?  185 GLU A CB  1 
ATOM   1288 C  CG  . GLU A 1 185 ? -28.323 33.534  -19.499 1.00 73.94  ?  185 GLU A CG  1 
ATOM   1289 C  CD  . GLU A 1 185 ? -29.097 33.455  -20.806 1.00 79.11  ?  185 GLU A CD  1 
ATOM   1290 O  OE1 . GLU A 1 185 ? -28.470 33.585  -21.883 1.00 82.78  ?  185 GLU A OE1 1 
ATOM   1291 O  OE2 . GLU A 1 185 ? -30.331 33.259  -20.748 1.00 80.39  ?  185 GLU A OE2 1 
ATOM   1292 N  N   . SER A 1 186 ? -24.864 32.187  -18.380 1.00 60.94  ?  186 SER A N   1 
ATOM   1293 C  CA  . SER A 1 186 ? -24.515 30.915  -17.683 1.00 57.75  ?  186 SER A CA  1 
ATOM   1294 C  C   . SER A 1 186 ? -25.592 30.574  -16.648 1.00 58.74  ?  186 SER A C   1 
ATOM   1295 O  O   . SER A 1 186 ? -26.050 31.497  -15.946 1.00 62.40  ?  186 SER A O   1 
ATOM   1296 C  CB  . SER A 1 186 ? -23.156 30.992  -17.043 1.00 55.46  ?  186 SER A CB  1 
ATOM   1297 O  OG  . SER A 1 186 ? -22.878 29.825  -16.285 1.00 52.80  ?  186 SER A OG  1 
ATOM   1298 N  N   . PHE A 1 187 ? -25.968 29.294  -16.563 1.00 58.50  ?  187 PHE A N   1 
ATOM   1299 C  CA  . PHE A 1 187 ? -26.903 28.739  -15.546 1.00 57.70  ?  187 PHE A CA  1 
ATOM   1300 C  C   . PHE A 1 187 ? -26.141 27.840  -14.563 1.00 56.67  ?  187 PHE A C   1 
ATOM   1301 O  O   . PHE A 1 187 ? -26.795 27.139  -13.766 1.00 53.58  ?  187 PHE A O   1 
ATOM   1302 C  CB  . PHE A 1 187 ? -28.035 27.966  -16.226 1.00 58.42  ?  187 PHE A CB  1 
ATOM   1303 C  CG  . PHE A 1 187 ? -28.896 28.796  -17.142 1.00 59.71  ?  187 PHE A CG  1 
ATOM   1304 C  CD1 . PHE A 1 187 ? -29.535 29.933  -16.674 1.00 59.50  ?  187 PHE A CD1 1 
ATOM   1305 C  CD2 . PHE A 1 187 ? -29.080 28.434  -18.468 1.00 60.65  ?  187 PHE A CD2 1 
ATOM   1306 C  CE1 . PHE A 1 187 ? -30.330 30.696  -17.514 1.00 60.09  ?  187 PHE A CE1 1 
ATOM   1307 C  CE2 . PHE A 1 187 ? -29.877 29.198  -19.306 1.00 60.42  ?  187 PHE A CE2 1 
ATOM   1308 C  CZ  . PHE A 1 187 ? -30.500 30.327  -18.828 1.00 59.70  ?  187 PHE A CZ  1 
ATOM   1309 N  N   . LEU A 1 188 ? -24.805 27.867  -14.607 1.00 56.76  ?  188 LEU A N   1 
ATOM   1310 C  CA  . LEU A 1 188 ? -23.938 26.961  -13.807 1.00 56.26  ?  188 LEU A CA  1 
ATOM   1311 C  C   . LEU A 1 188 ? -24.114 27.289  -12.322 1.00 56.07  ?  188 LEU A C   1 
ATOM   1312 O  O   . LEU A 1 188 ? -24.034 28.482  -11.972 1.00 55.58  ?  188 LEU A O   1 
ATOM   1313 C  CB  . LEU A 1 188 ? -22.480 27.121  -14.251 1.00 55.92  ?  188 LEU A CB  1 
ATOM   1314 C  CG  . LEU A 1 188 ? -21.493 26.109  -13.671 1.00 56.24  ?  188 LEU A CG  1 
ATOM   1315 C  CD1 . LEU A 1 188 ? -21.864 24.687  -14.059 1.00 55.66  ?  188 LEU A CD1 1 
ATOM   1316 C  CD2 . LEU A 1 188 ? -20.074 26.419  -14.122 1.00 57.01  ?  188 LEU A CD2 1 
ATOM   1317 N  N   . GLY A 1 189 ? -24.386 26.267  -11.503 1.00 58.15  ?  189 GLY A N   1 
ATOM   1318 C  CA  . GLY A 1 189 ? -24.572 26.388  -10.042 1.00 61.60  ?  189 GLY A CA  1 
ATOM   1319 C  C   . GLY A 1 189 ? -25.962 26.878  -9.669  1.00 61.06  ?  189 GLY A C   1 
ATOM   1320 O  O   . GLY A 1 189 ? -26.233 27.017  -8.463  1.00 63.86  ?  189 GLY A O   1 
ATOM   1321 N  N   . GLN A 1 190 ? -26.814 27.126  -10.664 1.00 62.96  ?  190 GLN A N   1 
ATOM   1322 C  CA  . GLN A 1 190 ? -28.205 27.619  -10.489 1.00 65.46  ?  190 GLN A CA  1 
ATOM   1323 C  C   . GLN A 1 190 ? -29.121 26.418  -10.238 1.00 63.44  ?  190 GLN A C   1 
ATOM   1324 O  O   . GLN A 1 190 ? -28.951 25.396  -10.929 1.00 63.10  ?  190 GLN A O   1 
ATOM   1325 C  CB  . GLN A 1 190 ? -28.626 28.389  -11.741 1.00 69.37  ?  190 GLN A CB  1 
ATOM   1326 C  CG  . GLN A 1 190 ? -29.746 29.389  -11.517 1.00 73.79  ?  190 GLN A CG  1 
ATOM   1327 C  CD  . GLN A 1 190 ? -29.868 30.335  -12.688 1.00 77.16  ?  190 GLN A CD  1 
ATOM   1328 O  OE1 . GLN A 1 190 ? -28.876 30.860  -13.189 1.00 73.95  ?  190 GLN A OE1 1 
ATOM   1329 N  NE2 . GLN A 1 190 ? -31.092 30.561  -13.141 1.00 79.41  ?  190 GLN A NE2 1 
ATOM   1330 N  N   . TYR A 1 191 ? -30.048 26.538  -9.283  1.00 60.61  ?  191 TYR A N   1 
ATOM   1331 C  CA  . TYR A 1 191 ? -31.075 25.508  -8.976  1.00 57.48  ?  191 TYR A CA  1 
ATOM   1332 C  C   . TYR A 1 191 ? -32.424 25.915  -9.577  1.00 57.40  ?  191 TYR A C   1 
ATOM   1333 O  O   . TYR A 1 191 ? -32.667 27.123  -9.775  1.00 56.47  ?  191 TYR A O   1 
ATOM   1334 C  CB  . TYR A 1 191 ? -31.250 25.320  -7.470  1.00 55.01  ?  191 TYR A CB  1 
ATOM   1335 C  CG  . TYR A 1 191 ? -30.066 24.749  -6.736  1.00 53.25  ?  191 TYR A CG  1 
ATOM   1336 C  CD1 . TYR A 1 191 ? -28.924 25.505  -6.525  1.00 53.32  ?  191 TYR A CD1 1 
ATOM   1337 C  CD2 . TYR A 1 191 ? -30.105 23.472  -6.204  1.00 50.39  ?  191 TYR A CD2 1 
ATOM   1338 C  CE1 . TYR A 1 191 ? -27.842 24.998  -5.827  1.00 53.04  ?  191 TYR A CE1 1 
ATOM   1339 C  CE2 . TYR A 1 191 ? -29.033 22.951  -5.501  1.00 50.66  ?  191 TYR A CE2 1 
ATOM   1340 C  CZ  . TYR A 1 191 ? -27.897 23.716  -5.311  1.00 52.31  ?  191 TYR A CZ  1 
ATOM   1341 O  OH  . TYR A 1 191 ? -26.828 23.212  -4.628  1.00 55.09  ?  191 TYR A OH  1 
ATOM   1342 N  N   . PHE A 1 192 ? -33.267 24.920  -9.864  1.00 57.33  ?  192 PHE A N   1 
ATOM   1343 C  CA  A PHE A 1 192 ? -34.672 25.118  -10.314 0.50 57.88  ?  192 PHE A CA  1 
ATOM   1344 C  CA  B PHE A 1 192 ? -34.667 25.104  -10.330 0.50 57.79  ?  192 PHE A CA  1 
ATOM   1345 C  C   . PHE A 1 192 ? -35.574 24.179  -9.519  1.00 58.31  ?  192 PHE A C   1 
ATOM   1346 O  O   . PHE A 1 192 ? -35.164 23.083  -9.144  1.00 57.38  ?  192 PHE A O   1 
ATOM   1347 C  CB  A PHE A 1 192 ? -34.807 24.963  -11.834 0.50 57.99  ?  192 PHE A CB  1 
ATOM   1348 C  CB  B PHE A 1 192 ? -34.733 24.874  -11.842 0.50 57.81  ?  192 PHE A CB  1 
ATOM   1349 C  CG  A PHE A 1 192 ? -34.594 23.582  -12.405 0.50 58.11  ?  192 PHE A CG  1 
ATOM   1350 C  CG  B PHE A 1 192 ? -33.786 25.745  -12.631 0.50 57.82  ?  192 PHE A CG  1 
ATOM   1351 C  CD1 A PHE A 1 192 ? -35.498 22.556  -12.166 0.50 58.01  ?  192 PHE A CD1 1 
ATOM   1352 C  CD1 B PHE A 1 192 ? -32.427 25.468  -12.669 0.50 57.65  ?  192 PHE A CD1 1 
ATOM   1353 C  CD2 A PHE A 1 192 ? -33.517 23.325  -13.239 0.50 58.03  ?  192 PHE A CD2 1 
ATOM   1354 C  CD2 B PHE A 1 192 ? -34.247 26.858  -13.317 0.50 57.76  ?  192 PHE A CD2 1 
ATOM   1355 C  CE1 A PHE A 1 192 ? -35.306 21.297  -12.713 0.50 57.51  ?  192 PHE A CE1 1 
ATOM   1356 C  CE1 B PHE A 1 192 ? -31.555 26.281  -13.376 0.50 58.48  ?  192 PHE A CE1 1 
ATOM   1357 C  CE2 A PHE A 1 192 ? -33.328 22.066  -13.788 0.50 57.96  ?  192 PHE A CE2 1 
ATOM   1358 C  CE2 B PHE A 1 192 ? -33.374 27.665  -14.029 0.50 58.17  ?  192 PHE A CE2 1 
ATOM   1359 C  CZ  A PHE A 1 192 ? -34.223 21.055  -13.526 0.50 57.77  ?  192 PHE A CZ  1 
ATOM   1360 C  CZ  B PHE A 1 192 ? -32.030 27.376  -14.057 0.50 58.75  ?  192 PHE A CZ  1 
ATOM   1361 N  N   . PRO A 1 193 ? -36.831 24.583  -9.220  1.00 59.70  ?  193 PRO A N   1 
ATOM   1362 C  CA  . PRO A 1 193 ? -37.707 23.778  -8.366  1.00 58.21  ?  193 PRO A CA  1 
ATOM   1363 C  C   . PRO A 1 193 ? -38.252 22.518  -9.056  1.00 56.24  ?  193 PRO A C   1 
ATOM   1364 O  O   . PRO A 1 193 ? -38.247 22.461  -10.270 1.00 54.93  ?  193 PRO A O   1 
ATOM   1365 C  CB  . PRO A 1 193 ? -38.838 24.758  -8.012  1.00 59.03  ?  193 PRO A CB  1 
ATOM   1366 C  CG  . PRO A 1 193 ? -38.907 25.693  -9.201  1.00 60.25  ?  193 PRO A CG  1 
ATOM   1367 C  CD  . PRO A 1 193 ? -37.475 25.825  -9.681  1.00 60.29  ?  193 PRO A CD  1 
ATOM   1368 N  N   . ALA A 1 194 ? -38.711 21.551  -8.253  1.00 55.19  ?  194 ALA A N   1 
ATOM   1369 C  CA  . ALA A 1 194 ? -39.227 20.233  -8.698  1.00 55.65  ?  194 ALA A CA  1 
ATOM   1370 C  C   . ALA A 1 194 ? -40.401 20.421  -9.667  1.00 55.79  ?  194 ALA A C   1 
ATOM   1371 O  O   . ALA A 1 194 ? -40.545 19.600  -10.591 1.00 55.17  ?  194 ALA A O   1 
ATOM   1372 C  CB  . ALA A 1 194 ? -39.635 19.409  -7.505  1.00 55.51  ?  194 ALA A CB  1 
ATOM   1373 N  N   . SER A 1 195 ? -41.208 21.461  -9.446  1.00 57.87  ?  195 SER A N   1 
ATOM   1374 C  CA  . SER A 1 195 ? -42.417 21.799  -10.245 1.00 59.64  ?  195 SER A CA  1 
ATOM   1375 C  C   . SER A 1 195 ? -42.042 22.159  -11.690 1.00 61.08  ?  195 SER A C   1 
ATOM   1376 O  O   . SER A 1 195 ? -42.904 21.987  -12.570 1.00 66.52  ?  195 SER A O   1 
ATOM   1377 C  CB  . SER A 1 195 ? -43.194 22.913  -9.598  1.00 60.42  ?  195 SER A CB  1 
ATOM   1378 O  OG  . SER A 1 195 ? -42.490 24.145  -9.693  1.00 62.51  ?  195 SER A OG  1 
ATOM   1379 N  N   . ASP A 1 196 ? -40.820 22.647  -11.931 1.00 58.94  ?  196 ASP A N   1 
ATOM   1380 C  CA  . ASP A 1 196 ? -40.338 23.008  -13.294 1.00 58.37  ?  196 ASP A CA  1 
ATOM   1381 C  C   . ASP A 1 196 ? -40.253 21.760  -14.187 1.00 58.05  ?  196 ASP A C   1 
ATOM   1382 O  O   . ASP A 1 196 ? -40.194 21.936  -15.416 1.00 57.73  ?  196 ASP A O   1 
ATOM   1383 C  CB  . ASP A 1 196 ? -39.002 23.755  -13.255 1.00 58.22  ?  196 ASP A CB  1 
ATOM   1384 C  CG  . ASP A 1 196 ? -39.146 25.227  -12.913 1.00 57.82  ?  196 ASP A CG  1 
ATOM   1385 O  OD1 . ASP A 1 196 ? -40.201 25.599  -12.367 1.00 61.91  ?  196 ASP A OD1 1 
ATOM   1386 O  OD2 . ASP A 1 196 ? -38.211 25.989  -13.206 1.00 55.83  ?  196 ASP A OD2 1 
ATOM   1387 N  N   . ILE A 1 197 ? -40.222 20.558  -13.604 1.00 58.87  ?  197 ILE A N   1 
ATOM   1388 C  CA  . ILE A 1 197 ? -40.327 19.266  -14.349 1.00 60.29  ?  197 ILE A CA  1 
ATOM   1389 C  C   . ILE A 1 197 ? -41.302 18.375  -13.586 1.00 65.86  ?  197 ILE A C   1 
ATOM   1390 O  O   . ILE A 1 197 ? -40.894 17.595  -12.730 1.00 66.58  ?  197 ILE A O   1 
ATOM   1391 C  CB  . ILE A 1 197 ? -38.947 18.599  -14.545 1.00 59.49  ?  197 ILE A CB  1 
ATOM   1392 C  CG1 . ILE A 1 197 ? -37.902 19.580  -15.090 1.00 58.61  ?  197 ILE A CG1 1 
ATOM   1393 C  CG2 . ILE A 1 197 ? -39.071 17.365  -15.428 1.00 59.39  ?  197 ILE A CG2 1 
ATOM   1394 C  CD1 . ILE A 1 197 ? -36.533 18.971  -15.309 1.00 57.84  ?  197 ILE A CD1 1 
ATOM   1395 N  N   . PRO A 1 198 ? -42.622 18.464  -13.869 1.00 72.41  ?  198 PRO A N   1 
ATOM   1396 C  CA  . PRO A 1 198 ? -43.621 17.730  -13.091 1.00 75.62  ?  198 PRO A CA  1 
ATOM   1397 C  C   . PRO A 1 198 ? -43.495 16.204  -13.250 1.00 77.45  ?  198 PRO A C   1 
ATOM   1398 O  O   . PRO A 1 198 ? -42.879 15.759  -14.198 1.00 75.93  ?  198 PRO A O   1 
ATOM   1399 C  CB  . PRO A 1 198 ? -44.963 18.272  -13.617 1.00 76.19  ?  198 PRO A CB  1 
ATOM   1400 C  CG  . PRO A 1 198 ? -44.657 18.801  -15.003 1.00 74.29  ?  198 PRO A CG  1 
ATOM   1401 C  CD  . PRO A 1 198 ? -43.219 19.272  -14.945 1.00 72.98  ?  198 PRO A CD  1 
ATOM   1402 N  N   . GLN A 1 199 ? -44.087 15.460  -12.307 1.00 81.11  ?  199 GLN A N   1 
ATOM   1403 C  CA  . GLN A 1 199 ? -43.902 13.993  -12.101 1.00 80.96  ?  199 GLN A CA  1 
ATOM   1404 C  C   . GLN A 1 199 ? -44.146 13.218  -13.406 1.00 78.95  ?  199 GLN A C   1 
ATOM   1405 O  O   . GLN A 1 199 ? -43.389 12.261  -13.665 1.00 77.63  ?  199 GLN A O   1 
ATOM   1406 C  CB  . GLN A 1 199 ? -44.827 13.495  -10.986 1.00 78.69  ?  199 GLN A CB  1 
ATOM   1407 N  N   . GLN A 1 200 ? -45.159 13.609  -14.186 1.00 78.21  ?  200 GLN A N   1 
ATOM   1408 C  CA  . GLN A 1 200 ? -45.581 12.899  -15.427 1.00 81.36  ?  200 GLN A CA  1 
ATOM   1409 C  C   . GLN A 1 200 ? -44.481 13.021  -16.491 1.00 78.35  ?  200 GLN A C   1 
ATOM   1410 O  O   . GLN A 1 200 ? -44.343 12.083  -17.305 1.00 78.76  ?  200 GLN A O   1 
ATOM   1411 C  CB  . GLN A 1 200 ? -46.930 13.415  -15.941 1.00 86.58  ?  200 GLN A CB  1 
ATOM   1412 C  CG  . GLN A 1 200 ? -46.936 14.877  -16.373 1.00 91.40  ?  200 GLN A CG  1 
ATOM   1413 C  CD  . GLN A 1 200 ? -47.245 15.837  -15.249 1.00 96.09  ?  200 GLN A CD  1 
ATOM   1414 O  OE1 . GLN A 1 200 ? -46.994 15.560  -14.078 1.00 97.66  ?  200 GLN A OE1 1 
ATOM   1415 N  NE2 . GLN A 1 200 ? -47.786 16.991  -15.605 1.00 100.57 ?  200 GLN A NE2 1 
ATOM   1416 N  N   . ALA A 1 201 ? -43.736 14.130  -16.482 1.00 74.41  ?  201 ALA A N   1 
ATOM   1417 C  CA  . ALA A 1 201 ? -42.586 14.384  -17.384 1.00 70.78  ?  201 ALA A CA  1 
ATOM   1418 C  C   . ALA A 1 201 ? -41.420 13.473  -16.982 1.00 68.10  ?  201 ALA A C   1 
ATOM   1419 O  O   . ALA A 1 201 ? -40.860 12.803  -17.864 1.00 68.75  ?  201 ALA A O   1 
ATOM   1420 C  CB  . ALA A 1 201 ? -42.200 15.841  -17.338 1.00 70.09  ?  201 ALA A CB  1 
ATOM   1421 N  N   . ARG A 1 202 ? -41.106 13.425  -15.685 1.00 66.03  ?  202 ARG A N   1 
ATOM   1422 C  CA  . ARG A 1 202 ? -40.024 12.572  -15.118 1.00 66.78  ?  202 ARG A CA  1 
ATOM   1423 C  C   . ARG A 1 202 ? -40.312 11.096  -15.413 1.00 69.29  ?  202 ARG A C   1 
ATOM   1424 O  O   . ARG A 1 202 ? -39.339 10.326  -15.557 1.00 73.55  ?  202 ARG A O   1 
ATOM   1425 C  CB  . ARG A 1 202 ? -39.899 12.788  -13.610 1.00 67.53  ?  202 ARG A CB  1 
ATOM   1426 C  CG  . ARG A 1 202 ? -39.446 14.186  -13.226 1.00 68.46  ?  202 ARG A CG  1 
ATOM   1427 C  CD  . ARG A 1 202 ? -39.765 14.485  -11.777 1.00 71.60  ?  202 ARG A CD  1 
ATOM   1428 N  NE  . ARG A 1 202 ? -39.533 15.888  -11.472 1.00 75.98  ?  202 ARG A NE  1 
ATOM   1429 C  CZ  . ARG A 1 202 ? -38.451 16.380  -10.876 1.00 76.18  ?  202 ARG A CZ  1 
ATOM   1430 N  NH1 . ARG A 1 202 ? -37.469 15.583  -10.487 1.00 77.58  ?  202 ARG A NH1 1 
ATOM   1431 N  NH2 . ARG A 1 202 ? -38.361 17.682  -10.666 1.00 75.71  ?  202 ARG A NH2 1 
ATOM   1432 N  N   . ALA A 1 203 ? -41.593 10.719  -15.487 1.00 69.22  ?  203 ALA A N   1 
ATOM   1433 C  CA  . ALA A 1 203 ? -42.052 9.347   -15.817 1.00 68.89  ?  203 ALA A CA  1 
ATOM   1434 C  C   . ALA A 1 203 ? -41.761 9.055   -17.292 1.00 67.79  ?  203 ALA A C   1 
ATOM   1435 O  O   . ALA A 1 203 ? -41.237 7.967   -17.584 1.00 68.63  ?  203 ALA A O   1 
ATOM   1436 C  CB  . ALA A 1 203 ? -43.517 9.188   -15.503 1.00 68.58  ?  203 ALA A CB  1 
ATOM   1437 N  N   . LEU A 1 204 ? -42.091 9.996   -18.181 1.00 67.61  ?  204 LEU A N   1 
ATOM   1438 C  CA  . LEU A 1 204 ? -41.825 9.882   -19.642 1.00 69.67  ?  204 LEU A CA  1 
ATOM   1439 C  C   . LEU A 1 204 ? -40.314 9.827   -19.882 1.00 69.36  ?  204 LEU A C   1 
ATOM   1440 O  O   . LEU A 1 204 ? -39.882 9.027   -20.740 1.00 74.05  ?  204 LEU A O   1 
ATOM   1441 C  CB  . LEU A 1 204 ? -42.440 11.070  -20.392 1.00 71.94  ?  204 LEU A CB  1 
ATOM   1442 C  CG  . LEU A 1 204 ? -43.879 10.897  -20.875 1.00 73.96  ?  204 LEU A CG  1 
ATOM   1443 C  CD1 . LEU A 1 204 ? -44.285 12.066  -21.759 1.00 74.04  ?  204 LEU A CD1 1 
ATOM   1444 C  CD2 . LEU A 1 204 ? -44.066 9.585   -21.625 1.00 75.40  ?  204 LEU A CD2 1 
ATOM   1445 N  N   . TYR A 1 205 ? -39.550 10.645  -19.150 1.00 66.15  ?  205 TYR A N   1 
ATOM   1446 C  CA  A TYR A 1 205 ? -38.081 10.770  -19.351 0.50 63.18  ?  205 TYR A CA  1 
ATOM   1447 C  CA  B TYR A 1 205 ? -38.074 10.789  -19.285 0.50 64.84  ?  205 TYR A CA  1 
ATOM   1448 C  C   . TYR A 1 205 ? -37.395 9.471   -18.902 1.00 62.80  ?  205 TYR A C   1 
ATOM   1449 O  O   . TYR A 1 205 ? -36.315 9.178   -19.423 1.00 61.51  ?  205 TYR A O   1 
ATOM   1450 C  CB  A TYR A 1 205 ? -37.564 12.048  -18.686 0.50 60.16  ?  205 TYR A CB  1 
ATOM   1451 C  CB  B TYR A 1 205 ? -37.531 11.913  -18.396 0.50 64.12  ?  205 TYR A CB  1 
ATOM   1452 C  CG  A TYR A 1 205 ? -38.301 13.284  -19.135 0.50 58.25  ?  205 TYR A CG  1 
ATOM   1453 C  CG  B TYR A 1 205 ? -37.618 13.301  -18.976 0.50 64.04  ?  205 TYR A CG  1 
ATOM   1454 C  CD1 A TYR A 1 205 ? -39.088 13.261  -20.276 0.50 57.70  ?  205 TYR A CD1 1 
ATOM   1455 C  CD1 B TYR A 1 205 ? -37.105 13.591  -20.230 0.50 65.60  ?  205 TYR A CD1 1 
ATOM   1456 C  CD2 A TYR A 1 205 ? -38.227 14.471  -18.426 0.50 58.11  ?  205 TYR A CD2 1 
ATOM   1457 C  CD2 B TYR A 1 205 ? -38.181 14.339  -18.253 0.50 64.94  ?  205 TYR A CD2 1 
ATOM   1458 C  CE1 A TYR A 1 205 ? -39.788 14.376  -20.699 0.50 56.67  ?  205 TYR A CE1 1 
ATOM   1459 C  CE1 B TYR A 1 205 ? -37.176 14.869  -20.762 0.50 66.22  ?  205 TYR A CE1 1 
ATOM   1460 C  CE2 A TYR A 1 205 ? -38.914 15.600  -18.840 0.50 58.62  ?  205 TYR A CE2 1 
ATOM   1461 C  CE2 B TYR A 1 205 ? -38.259 15.622  -18.768 0.50 66.35  ?  205 TYR A CE2 1 
ATOM   1462 C  CZ  A TYR A 1 205 ? -39.696 15.553  -19.981 0.50 57.74  ?  205 TYR A CZ  1 
ATOM   1463 C  CZ  B TYR A 1 205 ? -37.756 15.889  -20.029 0.50 67.06  ?  205 TYR A CZ  1 
ATOM   1464 O  OH  A TYR A 1 205 ? -40.379 16.656  -20.404 0.50 58.50  ?  205 TYR A OH  1 
ATOM   1465 O  OH  B TYR A 1 205 ? -37.834 17.156  -20.535 0.50 66.17  ?  205 TYR A OH  1 
ATOM   1466 N  N   . LEU A 1 206 ? -38.028 8.715   -18.002 1.00 65.56  ?  206 LEU A N   1 
ATOM   1467 C  CA  . LEU A 1 206 ? -37.532 7.391   -17.538 1.00 68.74  ?  206 LEU A CA  1 
ATOM   1468 C  C   . LEU A 1 206 ? -37.825 6.322   -18.601 1.00 68.10  ?  206 LEU A C   1 
ATOM   1469 O  O   . LEU A 1 206 ? -37.119 5.300   -18.603 1.00 67.65  ?  206 LEU A O   1 
ATOM   1470 C  CB  . LEU A 1 206 ? -38.200 7.052   -16.200 1.00 70.52  ?  206 LEU A CB  1 
ATOM   1471 C  CG  . LEU A 1 206 ? -37.555 5.922   -15.400 1.00 74.33  ?  206 LEU A CG  1 
ATOM   1472 C  CD1 . LEU A 1 206 ? -36.108 6.243   -15.056 1.00 76.13  ?  206 LEU A CD1 1 
ATOM   1473 C  CD2 . LEU A 1 206 ? -38.347 5.642   -14.132 1.00 77.15  ?  206 LEU A CD2 1 
ATOM   1474 N  N   . LYS A 1 207 ? -38.817 6.561   -19.469 1.00 70.81  ?  207 LYS A N   1 
ATOM   1475 C  CA  . LYS A 1 207 ? -39.285 5.612   -20.520 1.00 73.69  ?  207 LYS A CA  1 
ATOM   1476 C  C   . LYS A 1 207 ? -38.611 5.917   -21.863 1.00 72.02  ?  207 LYS A C   1 
ATOM   1477 O  O   . LYS A 1 207 ? -38.368 4.958   -22.613 1.00 69.87  ?  207 LYS A O   1 
ATOM   1478 C  CB  . LYS A 1 207 ? -40.808 5.682   -20.675 1.00 79.29  ?  207 LYS A CB  1 
ATOM   1479 C  CG  . LYS A 1 207 ? -41.603 5.023   -19.555 1.00 83.84  ?  207 LYS A CG  1 
ATOM   1480 C  CD  . LYS A 1 207 ? -43.091 5.305   -19.611 1.00 86.64  ?  207 LYS A CD  1 
ATOM   1481 C  CE  . LYS A 1 207 ? -43.839 4.757   -18.414 1.00 89.24  ?  207 LYS A CE  1 
ATOM   1482 N  NZ  . LYS A 1 207 ? -45.293 5.022   -18.511 1.00 90.75  ?  207 LYS A NZ  1 
ATOM   1483 N  N   . ASN A 1 208 ? -38.353 7.196   -22.163 1.00 74.61  ?  208 ASN A N   1 
ATOM   1484 C  CA  . ASN A 1 208 ? -37.644 7.652   -23.392 1.00 76.19  ?  208 ASN A CA  1 
ATOM   1485 C  C   . ASN A 1 208 ? -36.235 8.124   -23.031 1.00 71.59  ?  208 ASN A C   1 
ATOM   1486 O  O   . ASN A 1 208 ? -36.126 9.120   -22.302 1.00 73.25  ?  208 ASN A O   1 
ATOM   1487 C  CB  . ASN A 1 208 ? -38.379 8.794   -24.098 1.00 82.78  ?  208 ASN A CB  1 
ATOM   1488 C  CG  . ASN A 1 208 ? -39.573 8.328   -24.903 1.00 88.07  ?  208 ASN A CG  1 
ATOM   1489 O  OD1 . ASN A 1 208 ? -39.572 7.225   -25.446 1.00 92.55  ?  208 ASN A OD1 1 
ATOM   1490 N  ND2 . ASN A 1 208 ? -40.587 9.171   -25.000 1.00 91.80  ?  208 ASN A ND2 1 
ATOM   1491 N  N   . THR A 1 209 ? -35.208 7.441   -23.543 1.00 69.86  ?  209 THR A N   1 
ATOM   1492 C  CA  . THR A 1 209 ? -33.774 7.779   -23.325 1.00 69.72  ?  209 THR A CA  1 
ATOM   1493 C  C   . THR A 1 209 ? -33.530 9.243   -23.710 1.00 66.79  ?  209 THR A C   1 
ATOM   1494 O  O   . THR A 1 209 ? -33.006 9.984   -22.860 1.00 65.72  ?  209 THR A O   1 
ATOM   1495 C  CB  . THR A 1 209 ? -32.857 6.801   -24.072 1.00 71.67  ?  209 THR A CB  1 
ATOM   1496 O  OG1 . THR A 1 209 ? -33.033 5.540   -23.427 1.00 74.30  ?  209 THR A OG1 1 
ATOM   1497 C  CG2 . THR A 1 209 ? -31.393 7.190   -24.055 1.00 73.05  ?  209 THR A CG2 1 
ATOM   1498 N  N   . LEU A 1 210 ? -33.889 9.650   -24.932 1.00 65.36  ?  210 LEU A N   1 
ATOM   1499 C  CA  . LEU A 1 210 ? -33.716 11.059  -25.378 1.00 68.43  ?  210 LEU A CA  1 
ATOM   1500 C  C   . LEU A 1 210 ? -35.017 11.597  -25.986 1.00 64.46  ?  210 LEU A C   1 
ATOM   1501 O  O   . LEU A 1 210 ? -35.911 10.799  -26.295 1.00 65.61  ?  210 LEU A O   1 
ATOM   1502 C  CB  . LEU A 1 210 ? -32.517 11.180  -26.327 1.00 71.62  ?  210 LEU A CB  1 
ATOM   1503 C  CG  . LEU A 1 210 ? -32.652 10.538  -27.705 1.00 73.16  ?  210 LEU A CG  1 
ATOM   1504 C  CD1 . LEU A 1 210 ? -33.480 11.405  -28.640 1.00 76.50  ?  210 LEU A CD1 1 
ATOM   1505 C  CD2 . LEU A 1 210 ? -31.279 10.298  -28.306 1.00 73.89  ?  210 LEU A CD2 1 
ATOM   1506 N  N   . ARG A 1 211 ? -35.067 12.920  -26.154 1.00 61.98  ?  211 ARG A N   1 
ATOM   1507 C  CA  A ARG A 1 211 ? -36.305 13.696  -26.453 0.50 61.10  ?  211 ARG A CA  1 
ATOM   1508 C  CA  B ARG A 1 211 ? -36.305 13.684  -26.483 0.50 61.85  ?  211 ARG A CA  1 
ATOM   1509 C  C   . ARG A 1 211 ? -35.916 14.936  -27.275 1.00 60.61  ?  211 ARG A C   1 
ATOM   1510 O  O   . ARG A 1 211 ? -35.068 15.698  -26.789 1.00 61.24  ?  211 ARG A O   1 
ATOM   1511 C  CB  A ARG A 1 211 ? -36.998 14.002  -25.117 0.50 59.89  ?  211 ARG A CB  1 
ATOM   1512 C  CB  B ARG A 1 211 ? -37.066 14.083  -25.213 0.50 61.60  ?  211 ARG A CB  1 
ATOM   1513 C  CG  A ARG A 1 211 ? -37.770 15.311  -25.048 0.50 58.55  ?  211 ARG A CG  1 
ATOM   1514 C  CG  B ARG A 1 211 ? -37.846 12.955  -24.555 0.50 61.34  ?  211 ARG A CG  1 
ATOM   1515 C  CD  A ARG A 1 211 ? -38.989 15.300  -25.940 0.50 57.18  ?  211 ARG A CD  1 
ATOM   1516 C  CD  B ARG A 1 211 ? -38.191 13.305  -23.121 0.50 60.15  ?  211 ARG A CD  1 
ATOM   1517 N  NE  A ARG A 1 211 ? -39.825 16.460  -25.703 0.50 55.70  ?  211 ARG A NE  1 
ATOM   1518 N  NE  B ARG A 1 211 ? -37.007 13.741  -22.395 0.50 58.99  ?  211 ARG A NE  1 
ATOM   1519 C  CZ  A ARG A 1 211 ? -40.985 16.665  -26.302 0.50 56.06  ?  211 ARG A CZ  1 
ATOM   1520 C  CZ  B ARG A 1 211 ? -36.013 12.937  -22.039 0.50 57.35  ?  211 ARG A CZ  1 
ATOM   1521 N  NH1 A ARG A 1 211 ? -41.442 15.785  -27.176 0.50 54.53  ?  211 ARG A NH1 1 
ATOM   1522 N  NH1 B ARG A 1 211 ? -36.062 11.654  -22.351 0.50 57.06  ?  211 ARG A NH1 1 
ATOM   1523 N  NH2 A ARG A 1 211 ? -41.688 17.743  -26.026 0.50 56.77  ?  211 ARG A NH2 1 
ATOM   1524 N  NH2 B ARG A 1 211 ? -34.973 13.414  -21.380 0.50 56.54  ?  211 ARG A NH2 1 
ATOM   1525 N  N   . ILE A 1 212 ? -36.520 15.114  -28.455 1.00 61.31  ?  212 ILE A N   1 
ATOM   1526 C  CA  . ILE A 1 212 ? -36.197 16.219  -29.409 1.00 61.97  ?  212 ILE A CA  1 
ATOM   1527 C  C   . ILE A 1 212 ? -37.321 17.255  -29.389 1.00 59.39  ?  212 ILE A C   1 
ATOM   1528 O  O   . ILE A 1 212 ? -38.491 16.855  -29.322 1.00 57.25  ?  212 ILE A O   1 
ATOM   1529 C  CB  . ILE A 1 212 ? -35.987 15.689  -30.842 1.00 66.82  ?  212 ILE A CB  1 
ATOM   1530 C  CG1 . ILE A 1 212 ? -35.114 14.433  -30.878 1.00 70.01  ?  212 ILE A CG1 1 
ATOM   1531 C  CG2 . ILE A 1 212 ? -35.430 16.785  -31.741 1.00 67.49  ?  212 ILE A CG2 1 
ATOM   1532 C  CD1 . ILE A 1 212 ? -33.648 14.707  -30.640 1.00 72.78  ?  212 ILE A CD1 1 
ATOM   1533 N  N   . ILE A 1 213 ? -36.950 18.534  -29.457 1.00 60.39  ?  213 ILE A N   1 
ATOM   1534 C  CA  . ILE A 1 213 ? -37.841 19.660  -29.863 1.00 62.26  ?  213 ILE A CA  1 
ATOM   1535 C  C   . ILE A 1 213 ? -37.166 20.366  -31.044 1.00 63.45  ?  213 ILE A C   1 
ATOM   1536 O  O   . ILE A 1 213 ? -36.187 21.099  -30.811 1.00 64.02  ?  213 ILE A O   1 
ATOM   1537 C  CB  . ILE A 1 213 ? -38.136 20.607  -28.682 1.00 63.25  ?  213 ILE A CB  1 
ATOM   1538 C  CG1 . ILE A 1 213 ? -38.939 19.893  -27.590 1.00 65.06  ?  213 ILE A CG1 1 
ATOM   1539 C  CG2 . ILE A 1 213 ? -38.838 21.873  -29.159 1.00 64.10  ?  213 ILE A CG2 1 
ATOM   1540 C  CD1 . ILE A 1 213 ? -39.237 20.743  -26.369 1.00 66.27  ?  213 ILE A CD1 1 
ATOM   1541 N  N   . SER A 1 214 ? -37.664 20.126  -32.262 1.00 64.20  ?  214 SER A N   1 
ATOM   1542 C  CA  . SER A 1 214 ? -37.113 20.687  -33.526 1.00 65.90  ?  214 SER A CA  1 
ATOM   1543 C  C   . SER A 1 214 ? -37.293 22.213  -33.564 1.00 65.42  ?  214 SER A C   1 
ATOM   1544 O  O   . SER A 1 214 ? -36.349 22.900  -33.995 1.00 63.82  ?  214 SER A O   1 
ATOM   1545 C  CB  . SER A 1 214 ? -37.737 20.028  -34.731 1.00 67.64  ?  214 SER A CB  1 
ATOM   1546 O  OG  . SER A 1 214 ? -39.154 20.113  -34.681 1.00 72.61  ?  214 SER A OG  1 
ATOM   1547 N  N   . ASP A 1 215 ? -38.453 22.721  -33.133 1.00 67.04  ?  215 ASP A N   1 
ATOM   1548 C  CA  . ASP A 1 215 ? -38.801 24.169  -33.206 1.00 71.55  ?  215 ASP A CA  1 
ATOM   1549 C  C   . ASP A 1 215 ? -39.874 24.506  -32.161 1.00 73.11  ?  215 ASP A C   1 
ATOM   1550 O  O   . ASP A 1 215 ? -41.045 24.137  -32.368 1.00 73.73  ?  215 ASP A O   1 
ATOM   1551 C  CB  . ASP A 1 215 ? -39.257 24.545  -34.620 1.00 74.26  ?  215 ASP A CB  1 
ATOM   1552 C  CG  . ASP A 1 215 ? -39.313 26.041  -34.886 1.00 73.94  ?  215 ASP A CG  1 
ATOM   1553 O  OD1 . ASP A 1 215 ? -39.602 26.801  -33.938 1.00 74.92  ?  215 ASP A OD1 1 
ATOM   1554 O  OD2 . ASP A 1 215 ? -39.068 26.432  -36.043 1.00 72.69  ?  215 ASP A OD2 1 
ATOM   1555 N  N   . ALA A 1 216 ? -39.484 25.215  -31.097 1.00 76.64  ?  216 ALA A N   1 
ATOM   1556 C  CA  . ALA A 1 216 ? -40.359 25.635  -29.975 1.00 81.39  ?  216 ALA A CA  1 
ATOM   1557 C  C   . ALA A 1 216 ? -41.447 26.591  -30.479 1.00 85.30  ?  216 ALA A C   1 
ATOM   1558 O  O   . ALA A 1 216 ? -42.535 26.613  -29.872 1.00 86.43  ?  216 ALA A O   1 
ATOM   1559 C  CB  . ALA A 1 216 ? -39.535 26.275  -28.884 1.00 81.13  ?  216 ALA A CB  1 
ATOM   1560 N  N   . SER A 1 217 ? -41.157 27.360  -31.535 1.00 87.17  ?  217 SER A N   1 
ATOM   1561 C  CA  . SER A 1 217 ? -42.103 28.326  -32.161 1.00 89.63  ?  217 SER A CA  1 
ATOM   1562 C  C   . SER A 1 217 ? -42.599 27.803  -33.517 1.00 90.36  ?  217 SER A C   1 
ATOM   1563 O  O   . SER A 1 217 ? -43.096 28.618  -34.316 1.00 95.30  ?  217 SER A O   1 
ATOM   1564 C  CB  . SER A 1 217 ? -41.456 29.680  -32.291 1.00 90.63  ?  217 SER A CB  1 
ATOM   1565 O  OG  . SER A 1 217 ? -40.317 29.614  -33.137 1.00 93.05  ?  217 SER A OG  1 
ATOM   1566 N  N   . GLY A 1 218 ? -42.472 26.496  -33.765 1.00 89.17  ?  218 GLY A N   1 
ATOM   1567 C  CA  . GLY A 1 218 ? -43.038 25.817  -34.948 1.00 88.04  ?  218 GLY A CA  1 
ATOM   1568 C  C   . GLY A 1 218 ? -44.519 25.535  -34.760 1.00 86.71  ?  218 GLY A C   1 
ATOM   1569 O  O   . GLY A 1 218 ? -44.988 25.611  -33.608 1.00 86.75  ?  218 GLY A O   1 
ATOM   1570 N  N   . THR A 1 219 ? -45.231 25.220  -35.846 1.00 87.00  ?  219 THR A N   1 
ATOM   1571 C  CA  . THR A 1 219 ? -46.703 24.974  -35.841 1.00 88.18  ?  219 THR A CA  1 
ATOM   1572 C  C   . THR A 1 219 ? -46.962 23.481  -35.648 1.00 82.91  ?  219 THR A C   1 
ATOM   1573 O  O   . THR A 1 219 ? -46.542 22.670  -36.470 1.00 82.07  ?  219 THR A O   1 
ATOM   1574 C  CB  . THR A 1 219 ? -47.374 25.498  -37.118 1.00 92.22  ?  219 THR A CB  1 
ATOM   1575 O  OG1 . THR A 1 219 ? -47.051 26.883  -37.256 1.00 96.64  ?  219 THR A OG1 1 
ATOM   1576 C  CG2 . THR A 1 219 ? -48.880 25.334  -37.111 1.00 92.59  ?  219 THR A CG2 1 
ATOM   1577 N  N   . PRO A 1 220 ? -47.662 23.073  -34.564 1.00 78.19  ?  220 PRO A N   1 
ATOM   1578 C  CA  . PRO A 1 220 ? -47.918 21.656  -34.306 1.00 78.25  ?  220 PRO A CA  1 
ATOM   1579 C  C   . PRO A 1 220 ? -48.942 21.055  -35.282 1.00 79.49  ?  220 PRO A C   1 
ATOM   1580 O  O   . PRO A 1 220 ? -49.953 21.684  -35.547 1.00 86.03  ?  220 PRO A O   1 
ATOM   1581 C  CB  . PRO A 1 220 ? -48.436 21.637  -32.859 1.00 76.94  ?  220 PRO A CB  1 
ATOM   1582 C  CG  . PRO A 1 220 ? -49.055 23.005  -32.664 1.00 77.78  ?  220 PRO A CG  1 
ATOM   1583 C  CD  . PRO A 1 220 ? -48.241 23.945  -33.530 1.00 77.72  ?  220 PRO A CD  1 
ATOM   1584 N  N   . ILE A 1 221 ? -48.644 19.856  -35.788 1.00 76.78  ?  221 ILE A N   1 
ATOM   1585 C  CA  . ILE A 1 221 ? -49.484 19.100  -36.764 1.00 77.04  ?  221 ILE A CA  1 
ATOM   1586 C  C   . ILE A 1 221 ? -50.441 18.210  -35.976 1.00 78.39  ?  221 ILE A C   1 
ATOM   1587 O  O   . ILE A 1 221 ? -49.992 17.334  -35.242 1.00 77.15  ?  221 ILE A O   1 
ATOM   1588 C  CB  . ILE A 1 221 ? -48.601 18.272  -37.721 1.00 78.63  ?  221 ILE A CB  1 
ATOM   1589 C  CG1 . ILE A 1 221 ? -47.434 19.080  -38.302 1.00 78.67  ?  221 ILE A CG1 1 
ATOM   1590 C  CG2 . ILE A 1 221 ? -49.445 17.632  -38.814 1.00 79.21  ?  221 ILE A CG2 1 
ATOM   1591 C  CD1 . ILE A 1 221 ? -47.832 20.373  -38.974 1.00 79.18  ?  221 ILE A CD1 1 
ATOM   1592 N  N   . PRO A 1 222 ? -51.779 18.391  -36.094 1.00 83.61  ?  222 PRO A N   1 
ATOM   1593 C  CA  . PRO A 1 222 ? -52.728 17.563  -35.348 1.00 82.99  ?  222 PRO A CA  1 
ATOM   1594 C  C   . PRO A 1 222 ? -52.768 16.107  -35.837 1.00 83.54  ?  222 PRO A C   1 
ATOM   1595 O  O   . PRO A 1 222 ? -52.413 15.851  -36.976 1.00 82.57  ?  222 PRO A O   1 
ATOM   1596 C  CB  . PRO A 1 222 ? -54.082 18.252  -35.576 1.00 81.51  ?  222 PRO A CB  1 
ATOM   1597 C  CG  . PRO A 1 222 ? -53.911 18.984  -36.891 1.00 83.80  ?  222 PRO A CG  1 
ATOM   1598 C  CD  . PRO A 1 222 ? -52.452 19.393  -36.937 1.00 84.80  ?  222 PRO A CD  1 
ATOM   1599 N  N   . VAL A 1 223 ? -53.178 15.198  -34.949 1.00 84.61  ?  223 VAL A N   1 
ATOM   1600 C  CA  . VAL A 1 223 ? -53.416 13.755  -35.247 1.00 89.76  ?  223 VAL A CA  1 
ATOM   1601 C  C   . VAL A 1 223 ? -54.925 13.562  -35.422 1.00 95.05  ?  223 VAL A C   1 
ATOM   1602 O  O   . VAL A 1 223 ? -55.687 14.098  -34.586 1.00 97.86  ?  223 VAL A O   1 
ATOM   1603 C  CB  . VAL A 1 223 ? -52.849 12.847  -34.138 1.00 89.80  ?  223 VAL A CB  1 
ATOM   1604 C  CG1 . VAL A 1 223 ? -53.084 11.372  -34.428 1.00 88.69  ?  223 VAL A CG1 1 
ATOM   1605 C  CG2 . VAL A 1 223 ? -51.371 13.112  -33.904 1.00 92.23  ?  223 VAL A CG2 1 
ATOM   1606 N  N   . LEU A 1 224 ? -55.328 12.833  -36.469 1.00 95.20  ?  224 LEU A N   1 
ATOM   1607 C  CA  . LEU A 1 224 ? -56.750 12.638  -36.868 1.00 92.90  ?  224 LEU A CA  1 
ATOM   1608 C  C   . LEU A 1 224 ? -57.086 11.148  -36.832 1.00 92.75  ?  224 LEU A C   1 
ATOM   1609 O  O   . LEU A 1 224 ? -56.417 10.355  -37.491 1.00 95.41  ?  224 LEU A O   1 
ATOM   1610 C  CB  . LEU A 1 224 ? -56.958 13.209  -38.276 1.00 92.84  ?  224 LEU A CB  1 
ATOM   1611 C  CG  . LEU A 1 224 ? -56.386 14.605  -38.525 1.00 96.04  ?  224 LEU A CG  1 
ATOM   1612 C  CD1 . LEU A 1 224 ? -56.537 15.000  -39.986 1.00 98.04  ?  224 LEU A CD1 1 
ATOM   1613 C  CD2 . LEU A 1 224 ? -57.044 15.639  -37.622 1.00 97.03  ?  224 LEU A CD2 1 
ATOM   1614 N  N   . PRO A 1 225 ? -58.117 10.705  -36.073 1.00 91.75  ?  225 PRO A N   1 
ATOM   1615 C  CA  . PRO A 1 225 ? -58.776 11.529  -35.059 1.00 92.66  ?  225 PRO A CA  1 
ATOM   1616 C  C   . PRO A 1 225 ? -57.975 11.637  -33.752 1.00 94.18  ?  225 PRO A C   1 
ATOM   1617 O  O   . PRO A 1 225 ? -57.250 10.709  -33.426 1.00 88.02  ?  225 PRO A O   1 
ATOM   1618 C  CB  . PRO A 1 225 ? -60.077 10.759  -34.802 1.00 92.43  ?  225 PRO A CB  1 
ATOM   1619 C  CG  . PRO A 1 225 ? -59.673 9.315   -34.997 1.00 91.69  ?  225 PRO A CG  1 
ATOM   1620 C  CD  . PRO A 1 225 ? -58.713 9.361   -36.168 1.00 90.82  ?  225 PRO A CD  1 
ATOM   1621 N  N   . ALA A 1 226 ? -58.140 12.755  -33.037 1.00 97.04  ?  226 ALA A N   1 
ATOM   1622 C  CA  . ALA A 1 226 ? -57.566 12.999  -31.690 1.00 97.43  ?  226 ALA A CA  1 
ATOM   1623 C  C   . ALA A 1 226 ? -58.129 11.963  -30.709 1.00 98.04  ?  226 ALA A C   1 
ATOM   1624 O  O   . ALA A 1 226 ? -57.331 11.311  -30.007 1.00 99.28  ?  226 ALA A O   1 
ATOM   1625 C  CB  . ALA A 1 226 ? -57.866 14.410  -31.245 1.00 96.95  ?  226 ALA A CB  1 
ATOM   1626 N  N   . VAL A 1 227 ? -59.457 11.822  -30.682 1.00 100.79 ?  227 VAL A N   1 
ATOM   1627 C  CA  . VAL A 1 227 ? -60.201 10.807  -29.874 1.00 101.56 ?  227 VAL A CA  1 
ATOM   1628 C  C   . VAL A 1 227 ? -60.951 9.886   -30.845 1.00 100.80 ?  227 VAL A C   1 
ATOM   1629 O  O   . VAL A 1 227 ? -61.618 10.415  -31.755 1.00 101.26 ?  227 VAL A O   1 
ATOM   1630 C  CB  . VAL A 1 227 ? -61.165 11.481  -28.876 1.00 101.67 ?  227 VAL A CB  1 
ATOM   1631 C  CG1 . VAL A 1 227 ? -61.727 10.484  -27.875 1.00 100.21 ?  227 VAL A CG1 1 
ATOM   1632 C  CG2 . VAL A 1 227 ? -60.514 12.651  -28.151 1.00 100.01 ?  227 VAL A CG2 1 
ATOM   1633 N  N   . ASP A 1 228 ? -60.849 8.565   -30.656 1.00 99.40  ?  228 ASP A N   1 
ATOM   1634 C  CA  . ASP A 1 228 ? -61.480 7.545   -31.541 1.00 100.35 ?  228 ASP A CA  1 
ATOM   1635 C  C   . ASP A 1 228 ? -62.902 7.257   -31.033 1.00 104.07 ?  228 ASP A C   1 
ATOM   1636 O  O   . ASP A 1 228 ? -63.393 8.029   -30.181 1.00 99.52  ?  228 ASP A O   1 
ATOM   1637 C  CB  . ASP A 1 228 ? -60.596 6.298   -31.676 1.00 97.75  ?  228 ASP A CB  1 
ATOM   1638 C  CG  . ASP A 1 228 ? -60.621 5.335   -30.498 1.00 97.32  ?  228 ASP A CG  1 
ATOM   1639 O  OD1 . ASP A 1 228 ? -61.117 5.723   -29.422 1.00 95.74  ?  228 ASP A OD1 1 
ATOM   1640 O  OD2 . ASP A 1 228 ? -60.131 4.199   -30.667 1.00 93.70  ?  228 ASP A OD2 1 
ATOM   1641 N  N   . VAL A 1 229 ? -63.533 6.196   -31.553 0.90 108.66 ?  229 VAL A N   1 
ATOM   1642 C  CA  . VAL A 1 229 ? -64.943 5.794   -31.255 0.90 108.26 ?  229 VAL A CA  1 
ATOM   1643 C  C   . VAL A 1 229 ? -65.087 5.545   -29.749 0.90 109.38 ?  229 VAL A C   1 
ATOM   1644 O  O   . VAL A 1 229 ? -65.958 6.183   -29.122 0.90 105.15 ?  229 VAL A O   1 
ATOM   1645 C  CB  . VAL A 1 229 ? -65.353 4.550   -32.070 1.00 102.74 ?  229 VAL A CB  1 
ATOM   1646 N  N   . SER A 1 230 ? -64.238 4.671   -29.199 1.00 111.46 ?  230 SER A N   1 
ATOM   1647 C  CA  . SER A 1 230 ? -64.281 4.201   -27.783 1.00 114.06 ?  230 SER A CA  1 
ATOM   1648 C  C   . SER A 1 230 ? -64.034 5.354   -26.798 1.00 114.27 ?  230 SER A C   1 
ATOM   1649 O  O   . SER A 1 230 ? -64.287 5.151   -25.592 1.00 116.82 ?  230 SER A O   1 
ATOM   1650 C  CB  . SER A 1 230 ? -63.306 3.071   -27.550 1.00 115.76 ?  230 SER A CB  1 
ATOM   1651 O  OG  . SER A 1 230 ? -62.042 3.361   -28.128 1.00 116.23 ?  230 SER A OG  1 
ATOM   1652 N  N   . GLY A 1 231 ? -63.551 6.504   -27.283 1.00 112.34 ?  231 GLY A N   1 
ATOM   1653 C  CA  . GLY A 1 231 ? -63.314 7.718   -26.475 1.00 110.58 ?  231 GLY A CA  1 
ATOM   1654 C  C   . GLY A 1 231 ? -61.881 7.806   -25.971 1.00 108.76 ?  231 GLY A C   1 
ATOM   1655 O  O   . GLY A 1 231 ? -61.621 8.658   -25.098 1.00 106.20 ?  231 GLY A O   1 
ATOM   1656 N  N   . GLU A 1 232 ? -60.985 6.968   -26.508 1.00 106.63 ?  232 GLU A N   1 
ATOM   1657 C  CA  . GLU A 1 232 ? -59.551 6.883   -26.113 1.00 103.42 ?  232 GLU A CA  1 
ATOM   1658 C  C   . GLU A 1 232 ? -58.730 7.864   -26.946 1.00 98.44  ?  232 GLU A C   1 
ATOM   1659 O  O   . GLU A 1 232 ? -58.995 8.042   -28.133 1.00 94.83  ?  232 GLU A O   1 
ATOM   1660 C  CB  . GLU A 1 232 ? -59.013 5.465   -26.318 1.00 105.53 ?  232 GLU A CB  1 
ATOM   1661 C  CG  . GLU A 1 232 ? -59.718 4.412   -25.483 1.00 110.31 ?  232 GLU A CG  1 
ATOM   1662 C  CD  . GLU A 1 232 ? -59.465 4.512   -23.988 1.00 114.18 ?  232 GLU A CD  1 
ATOM   1663 O  OE1 . GLU A 1 232 ? -58.677 3.696   -23.473 1.00 118.69 ?  232 GLU A OE1 1 
ATOM   1664 O  OE2 . GLU A 1 232 ? -60.065 5.398   -23.342 1.00 114.52 ?  232 GLU A OE2 1 
ATOM   1665 N  N   . PRO A 1 233 ? -57.714 8.533   -26.350 1.00 93.20  ?  233 PRO A N   1 
ATOM   1666 C  CA  . PRO A 1 233 ? -56.735 9.299   -27.117 1.00 89.41  ?  233 PRO A CA  1 
ATOM   1667 C  C   . PRO A 1 233 ? -55.560 8.410   -27.547 1.00 83.13  ?  233 PRO A C   1 
ATOM   1668 O  O   . PRO A 1 233 ? -55.458 7.301   -27.052 1.00 77.05  ?  233 PRO A O   1 
ATOM   1669 C  CB  . PRO A 1 233 ? -56.293 10.356  -26.099 1.00 90.57  ?  233 PRO A CB  1 
ATOM   1670 C  CG  . PRO A 1 233 ? -56.319 9.605   -24.780 1.00 92.63  ?  233 PRO A CG  1 
ATOM   1671 C  CD  . PRO A 1 233 ? -57.449 8.600   -24.904 1.00 93.37  ?  233 PRO A CD  1 
ATOM   1672 N  N   . LEU A 1 234 ? -54.718 8.914   -28.454 1.00 81.67  ?  234 LEU A N   1 
ATOM   1673 C  CA  . LEU A 1 234 ? -53.482 8.221   -28.910 1.00 81.07  ?  234 LEU A CA  1 
ATOM   1674 C  C   . LEU A 1 234 ? -52.355 8.529   -27.920 1.00 78.24  ?  234 LEU A C   1 
ATOM   1675 O  O   . LEU A 1 234 ? -51.997 9.715   -27.784 1.00 76.61  ?  234 LEU A O   1 
ATOM   1676 C  CB  . LEU A 1 234 ? -53.119 8.685   -30.324 1.00 81.34  ?  234 LEU A CB  1 
ATOM   1677 C  CG  . LEU A 1 234 ? -51.911 7.991   -30.953 1.00 81.81  ?  234 LEU A CG  1 
ATOM   1678 C  CD1 . LEU A 1 234 ? -52.149 6.493   -31.090 1.00 81.29  ?  234 LEU A CD1 1 
ATOM   1679 C  CD2 . LEU A 1 234 ? -51.579 8.604   -32.306 1.00 82.34  ?  234 LEU A CD2 1 
ATOM   1680 N  N   . ASP A 1 235 ? -51.835 7.496   -27.250 1.00 75.19  ?  235 ASP A N   1 
ATOM   1681 C  CA  . ASP A 1 235 ? -50.728 7.611   -26.266 1.00 74.40  ?  235 ASP A CA  1 
ATOM   1682 C  C   . ASP A 1 235 ? -49.404 7.705   -27.031 1.00 72.51  ?  235 ASP A C   1 
ATOM   1683 O  O   . ASP A 1 235 ? -48.976 6.681   -27.599 1.00 72.72  ?  235 ASP A O   1 
ATOM   1684 C  CB  . ASP A 1 235 ? -50.747 6.440   -25.283 1.00 75.91  ?  235 ASP A CB  1 
ATOM   1685 C  CG  . ASP A 1 235 ? -49.933 6.696   -24.029 1.00 77.62  ?  235 ASP A CG  1 
ATOM   1686 O  OD1 . ASP A 1 235 ? -48.907 7.391   -24.133 1.00 79.13  ?  235 ASP A OD1 1 
ATOM   1687 O  OD2 . ASP A 1 235 ? -50.338 6.204   -22.957 1.00 83.63  ?  235 ASP A OD2 1 
ATOM   1688 N  N   . LEU A 1 236 ? -48.788 8.892   -27.042 1.00 70.57  ?  236 LEU A N   1 
ATOM   1689 C  CA  . LEU A 1 236 ? -47.525 9.177   -27.779 1.00 72.06  ?  236 LEU A CA  1 
ATOM   1690 C  C   . LEU A 1 236 ? -46.329 9.122   -26.817 1.00 70.63  ?  236 LEU A C   1 
ATOM   1691 O  O   . LEU A 1 236 ? -45.336 9.831   -27.071 1.00 67.47  ?  236 LEU A O   1 
ATOM   1692 C  CB  . LEU A 1 236 ? -47.644 10.552  -28.447 1.00 71.73  ?  236 LEU A CB  1 
ATOM   1693 C  CG  . LEU A 1 236 ? -48.751 10.687  -29.493 1.00 70.35  ?  236 LEU A CG  1 
ATOM   1694 C  CD1 . LEU A 1 236 ? -48.852 12.122  -29.986 1.00 68.94  ?  236 LEU A CD1 1 
ATOM   1695 C  CD2 . LEU A 1 236 ? -48.522 9.737   -30.660 1.00 70.51  ?  236 LEU A CD2 1 
ATOM   1696 N  N   . SER A 1 237 ? -46.414 8.292   -25.773 1.00 69.96  ?  237 SER A N   1 
ATOM   1697 C  CA  . SER A 1 237 ? -45.388 8.180   -24.699 1.00 67.60  ?  237 SER A CA  1 
ATOM   1698 C  C   . SER A 1 237 ? -44.013 7.844   -25.287 1.00 67.28  ?  237 SER A C   1 
ATOM   1699 O  O   . SER A 1 237 ? -43.026 8.435   -24.824 1.00 69.43  ?  237 SER A O   1 
ATOM   1700 C  CB  . SER A 1 237 ? -45.786 7.175   -23.655 1.00 67.59  ?  237 SER A CB  1 
ATOM   1701 O  OG  . SER A 1 237 ? -46.679 7.752   -22.715 1.00 67.89  ?  237 SER A OG  1 
ATOM   1702 N  N   . TYR A 1 238 ? -43.955 6.934   -26.262 1.00 67.50  ?  238 TYR A N   1 
ATOM   1703 C  CA  . TYR A 1 238 ? -42.692 6.397   -26.839 1.00 68.90  ?  238 TYR A CA  1 
ATOM   1704 C  C   . TYR A 1 238 ? -42.447 6.965   -28.244 1.00 67.75  ?  238 TYR A C   1 
ATOM   1705 O  O   . TYR A 1 238 ? -41.480 6.532   -28.903 1.00 66.78  ?  238 TYR A O   1 
ATOM   1706 C  CB  . TYR A 1 238 ? -42.729 4.867   -26.860 1.00 71.00  ?  238 TYR A CB  1 
ATOM   1707 C  CG  . TYR A 1 238 ? -42.704 4.217   -25.501 1.00 73.69  ?  238 TYR A CG  1 
ATOM   1708 C  CD1 . TYR A 1 238 ? -41.504 3.913   -24.876 1.00 75.79  ?  238 TYR A CD1 1 
ATOM   1709 C  CD2 . TYR A 1 238 ? -43.878 3.898   -24.838 1.00 75.96  ?  238 TYR A CD2 1 
ATOM   1710 C  CE1 . TYR A 1 238 ? -41.471 3.309   -23.629 1.00 78.98  ?  238 TYR A CE1 1 
ATOM   1711 C  CE2 . TYR A 1 238 ? -43.863 3.296   -23.590 1.00 79.51  ?  238 TYR A CE2 1 
ATOM   1712 C  CZ  . TYR A 1 238 ? -42.654 2.995   -22.984 1.00 81.53  ?  238 TYR A CZ  1 
ATOM   1713 O  OH  . TYR A 1 238 ? -42.629 2.397   -21.755 1.00 82.98  ?  238 TYR A OH  1 
ATOM   1714 N  N   . ALA A 1 239 ? -43.288 7.904   -28.685 1.00 68.18  ?  239 ALA A N   1 
ATOM   1715 C  CA  . ALA A 1 239 ? -43.190 8.568   -30.008 1.00 66.48  ?  239 ALA A CA  1 
ATOM   1716 C  C   . ALA A 1 239 ? -42.243 9.766   -29.892 1.00 65.07  ?  239 ALA A C   1 
ATOM   1717 O  O   . ALA A 1 239 ? -42.492 10.632  -29.034 1.00 65.65  ?  239 ALA A O   1 
ATOM   1718 C  CB  . ALA A 1 239 ? -44.558 8.991   -30.484 1.00 66.16  ?  239 ALA A CB  1 
ATOM   1719 N  N   . HIS A 1 240 ? -41.201 9.812   -30.725 1.00 63.26  ?  240 HIS A N   1 
ATOM   1720 C  CA  . HIS A 1 240 ? -40.198 10.910  -30.734 1.00 64.27  ?  240 HIS A CA  1 
ATOM   1721 C  C   . HIS A 1 240 ? -40.825 12.191  -31.298 1.00 63.51  ?  240 HIS A C   1 
ATOM   1722 O  O   . HIS A 1 240 ? -40.316 13.273  -30.967 1.00 66.15  ?  240 HIS A O   1 
ATOM   1723 C  CB  . HIS A 1 240 ? -38.922 10.485  -31.470 1.00 64.48  ?  240 HIS A CB  1 
ATOM   1724 C  CG  . HIS A 1 240 ? -39.023 10.504  -32.956 1.00 64.30  ?  240 HIS A CG  1 
ATOM   1725 N  ND1 . HIS A 1 240 ? -38.793 11.649  -33.693 1.00 67.05  ?  240 HIS A ND1 1 
ATOM   1726 C  CD2 . HIS A 1 240 ? -39.286 9.520   -33.843 1.00 65.14  ?  240 HIS A CD2 1 
ATOM   1727 C  CE1 . HIS A 1 240 ? -38.927 11.373  -34.975 1.00 69.00  ?  240 HIS A CE1 1 
ATOM   1728 N  NE2 . HIS A 1 240 ? -39.231 10.071  -35.094 1.00 66.61  ?  240 HIS A NE2 1 
ATOM   1729 N  N   . LEU A 1 241 ? -41.896 12.075  -32.092 1.00 64.11  ?  241 LEU A N   1 
ATOM   1730 C  CA  . LEU A 1 241 ? -42.591 13.231  -32.726 1.00 63.46  ?  241 LEU A CA  1 
ATOM   1731 C  C   . LEU A 1 241 ? -43.625 13.848  -31.773 1.00 62.69  ?  241 LEU A C   1 
ATOM   1732 O  O   . LEU A 1 241 ? -44.140 14.930  -32.115 1.00 60.78  ?  241 LEU A O   1 
ATOM   1733 C  CB  . LEU A 1 241 ? -43.256 12.779  -34.031 1.00 63.54  ?  241 LEU A CB  1 
ATOM   1734 C  CG  . LEU A 1 241 ? -42.300 12.432  -35.171 1.00 62.70  ?  241 LEU A CG  1 
ATOM   1735 C  CD1 . LEU A 1 241 ? -43.047 11.785  -36.324 1.00 63.57  ?  241 LEU A CD1 1 
ATOM   1736 C  CD2 . LEU A 1 241 ? -41.555 13.667  -35.653 1.00 63.45  ?  241 LEU A CD2 1 
ATOM   1737 N  N   . ARG A 1 242 ? -43.920 13.209  -30.634 1.00 62.53  ?  242 ARG A N   1 
ATOM   1738 C  CA  . ARG A 1 242 ? -44.851 13.763  -29.605 1.00 63.29  ?  242 ARG A CA  1 
ATOM   1739 C  C   . ARG A 1 242 ? -44.572 15.261  -29.428 1.00 63.74  ?  242 ARG A C   1 
ATOM   1740 O  O   . ARG A 1 242 ? -43.389 15.646  -29.387 1.00 68.85  ?  242 ARG A O   1 
ATOM   1741 C  CB  . ARG A 1 242 ? -44.698 13.026  -28.271 1.00 63.29  ?  242 ARG A CB  1 
ATOM   1742 C  CG  . ARG A 1 242 ? -45.550 13.579  -27.134 1.00 63.36  ?  242 ARG A CG  1 
ATOM   1743 C  CD  . ARG A 1 242 ? -45.296 12.864  -25.816 1.00 65.78  ?  242 ARG A CD  1 
ATOM   1744 N  NE  . ARG A 1 242 ? -43.909 13.001  -25.387 1.00 67.43  ?  242 ARG A NE  1 
ATOM   1745 C  CZ  . ARG A 1 242 ? -43.411 14.025  -24.693 1.00 69.45  ?  242 ARG A CZ  1 
ATOM   1746 N  NH1 . ARG A 1 242 ? -42.126 14.042  -24.379 1.00 70.96  ?  242 ARG A NH1 1 
ATOM   1747 N  NH2 . ARG A 1 242 ? -44.186 15.024  -24.306 1.00 69.89  ?  242 ARG A NH2 1 
ATOM   1748 N  N   . ASN A 1 243 ? -45.625 16.071  -29.321 1.00 64.70  ?  243 ASN A N   1 
ATOM   1749 C  CA  . ASN A 1 243 ? -45.522 17.549  -29.199 1.00 67.05  ?  243 ASN A CA  1 
ATOM   1750 C  C   . ASN A 1 243 ? -45.300 17.922  -27.729 1.00 66.90  ?  243 ASN A C   1 
ATOM   1751 O  O   . ASN A 1 243 ? -45.725 17.153  -26.851 1.00 68.76  ?  243 ASN A O   1 
ATOM   1752 C  CB  . ASN A 1 243 ? -46.754 18.248  -29.774 1.00 68.37  ?  243 ASN A CB  1 
ATOM   1753 C  CG  . ASN A 1 243 ? -46.497 19.707  -30.076 1.00 68.29  ?  243 ASN A CG  1 
ATOM   1754 O  OD1 . ASN A 1 243 ? -45.693 20.029  -30.947 1.00 72.23  ?  243 ASN A OD1 1 
ATOM   1755 N  ND2 . ASN A 1 243 ? -47.165 20.595  -29.360 1.00 69.63  ?  243 ASN A ND2 1 
ATOM   1756 N  N   . PHE A 1 244 ? -44.654 19.064  -27.488 1.00 68.31  ?  244 PHE A N   1 
ATOM   1757 C  CA  . PHE A 1 244 ? -44.272 19.566  -26.142 1.00 70.09  ?  244 PHE A CA  1 
ATOM   1758 C  C   . PHE A 1 244 ? -45.428 20.360  -25.534 1.00 70.15  ?  244 PHE A C   1 
ATOM   1759 O  O   . PHE A 1 244 ? -46.205 20.972  -26.285 1.00 68.61  ?  244 PHE A O   1 
ATOM   1760 C  CB  . PHE A 1 244 ? -43.026 20.451  -26.234 1.00 72.46  ?  244 PHE A CB  1 
ATOM   1761 N  N   . SER A 1 245 ? -45.520 20.358  -24.203 1.00 72.75  ?  245 SER A N   1 
ATOM   1762 C  CA  . SER A 1 245 ? -46.443 21.242  -23.439 1.00 76.46  ?  245 SER A CA  1 
ATOM   1763 C  C   . SER A 1 245 ? -46.253 22.686  -23.905 1.00 77.28  ?  245 SER A C   1 
ATOM   1764 O  O   . SER A 1 245 ? -45.120 23.147  -24.039 1.00 74.28  ?  245 SER A O   1 
ATOM   1765 C  CB  . SER A 1 245 ? -46.224 21.118  -21.956 1.00 76.13  ?  245 SER A CB  1 
ATOM   1766 O  OG  . SER A 1 245 ? -46.862 22.179  -21.261 1.00 78.35  ?  245 SER A OG  1 
ATOM   1767 N  N   . PRO A 1 246 ? -47.340 23.450  -24.170 1.00 80.92  ?  246 PRO A N   1 
ATOM   1768 C  CA  . PRO A 1 246 ? -47.210 24.869  -24.506 1.00 81.02  ?  246 PRO A CA  1 
ATOM   1769 C  C   . PRO A 1 246 ? -46.567 25.671  -23.364 1.00 82.76  ?  246 PRO A C   1 
ATOM   1770 O  O   . PRO A 1 246 ? -46.040 26.740  -23.631 1.00 87.10  ?  246 PRO A O   1 
ATOM   1771 C  CB  . PRO A 1 246 ? -48.649 25.340  -24.774 1.00 79.99  ?  246 PRO A CB  1 
ATOM   1772 C  CG  . PRO A 1 246 ? -49.528 24.297  -24.109 1.00 80.85  ?  246 PRO A CG  1 
ATOM   1773 C  CD  . PRO A 1 246 ? -48.742 23.003  -24.165 1.00 80.87  ?  246 PRO A CD  1 
ATOM   1774 N  N   . ILE A 1 247 ? -46.609 25.135  -22.139 1.00 79.53  ?  247 ILE A N   1 
ATOM   1775 C  CA  . ILE A 1 247 ? -45.980 25.757  -20.934 1.00 79.59  ?  247 ILE A CA  1 
ATOM   1776 C  C   . ILE A 1 247 ? -44.459 25.753  -21.126 1.00 76.20  ?  247 ILE A C   1 
ATOM   1777 O  O   . ILE A 1 247 ? -43.841 26.829  -20.985 1.00 73.22  ?  247 ILE A O   1 
ATOM   1778 C  CB  . ILE A 1 247 ? -46.393 25.036  -19.634 1.00 82.22  ?  247 ILE A CB  1 
ATOM   1779 C  CG1 . ILE A 1 247 ? -47.913 24.942  -19.477 1.00 84.96  ?  247 ILE A CG1 1 
ATOM   1780 C  CG2 . ILE A 1 247 ? -45.750 25.702  -18.426 1.00 83.65  ?  247 ILE A CG2 1 
ATOM   1781 C  CD1 . ILE A 1 247 ? -48.618 26.280  -19.447 1.00 87.37  ?  247 ILE A CD1 1 
ATOM   1782 N  N   . HIS A 1 248 ? -43.883 24.588  -21.438 1.00 70.89  ?  248 HIS A N   1 
ATOM   1783 C  CA  . HIS A 1 248 ? -42.419 24.423  -21.644 1.00 70.01  ?  248 HIS A CA  1 
ATOM   1784 C  C   . HIS A 1 248 ? -41.980 25.200  -22.888 1.00 68.80  ?  248 HIS A C   1 
ATOM   1785 O  O   . HIS A 1 248 ? -40.928 25.868  -22.829 1.00 68.45  ?  248 HIS A O   1 
ATOM   1786 C  CB  . HIS A 1 248 ? -42.006 22.948  -21.731 1.00 70.64  ?  248 HIS A CB  1 
ATOM   1787 C  CG  . HIS A 1 248 ? -40.529 22.781  -21.869 1.00 68.51  ?  248 HIS A CG  1 
ATOM   1788 N  ND1 . HIS A 1 248 ? -39.638 23.414  -21.021 1.00 65.41  ?  248 HIS A ND1 1 
ATOM   1789 C  CD2 . HIS A 1 248 ? -39.783 22.093  -22.760 1.00 67.65  ?  248 HIS A CD2 1 
ATOM   1790 C  CE1 . HIS A 1 248 ? -38.407 23.118  -21.380 1.00 65.39  ?  248 HIS A CE1 1 
ATOM   1791 N  NE2 . HIS A 1 248 ? -38.467 22.306  -22.442 1.00 66.31  ?  248 HIS A NE2 1 
ATOM   1792 N  N   A CYS A 1 249 ? -42.753 25.074  -23.976 0.50 68.93  ?  249 CYS A N   1 
ATOM   1793 N  N   B CYS A 1 249 ? -42.762 25.145  -23.968 0.50 67.15  ?  249 CYS A N   1 
ATOM   1794 C  CA  A CYS A 1 249 ? -42.580 25.810  -25.263 0.50 69.25  ?  249 CYS A CA  1 
ATOM   1795 C  CA  B CYS A 1 249 ? -42.425 25.815  -25.255 0.50 66.27  ?  249 CYS A CA  1 
ATOM   1796 C  C   A CYS A 1 249 ? -42.393 27.308  -24.998 0.50 68.78  ?  249 CYS A C   1 
ATOM   1797 C  C   B CYS A 1 249 ? -42.450 27.345  -25.086 0.50 67.11  ?  249 CYS A C   1 
ATOM   1798 O  O   A CYS A 1 249 ? -41.452 27.902  -25.565 0.50 66.56  ?  249 CYS A O   1 
ATOM   1799 O  O   B CYS A 1 249 ? -41.686 28.017  -25.810 0.50 65.24  ?  249 CYS A O   1 
ATOM   1800 C  CB  A CYS A 1 249 ? -43.790 25.617  -26.171 0.50 70.26  ?  249 CYS A CB  1 
ATOM   1801 C  CB  B CYS A 1 249 ? -43.335 25.328  -26.376 0.50 65.27  ?  249 CYS A CB  1 
ATOM   1802 S  SG  A CYS A 1 249 ? -43.891 26.811  -27.534 0.50 69.14  ?  249 CYS A SG  1 
ATOM   1803 S  SG  B CYS A 1 249 ? -43.045 23.588  -26.808 0.50 59.83  ?  249 CYS A SG  1 
ATOM   1804 N  N   . GLU A 1 250 ? -43.261 27.879  -24.160 1.00 68.05  ?  250 GLU A N   1 
ATOM   1805 C  CA  . GLU A 1 250 ? -43.227 29.323  -23.792 1.00 71.36  ?  250 GLU A CA  1 
ATOM   1806 C  C   . GLU A 1 250 ? -41.959 29.604  -22.969 1.00 71.11  ?  250 GLU A C   1 
ATOM   1807 O  O   . GLU A 1 250 ? -41.359 30.681  -23.166 1.00 70.68  ?  250 GLU A O   1 
ATOM   1808 C  CB  . GLU A 1 250 ? -44.494 29.734  -23.038 1.00 75.45  ?  250 GLU A CB  1 
ATOM   1809 C  CG  . GLU A 1 250 ? -44.609 31.239  -22.839 1.00 78.60  ?  250 GLU A CG  1 
ATOM   1810 C  CD  . GLU A 1 250 ? -45.941 31.729  -22.295 1.00 79.47  ?  250 GLU A CD  1 
ATOM   1811 O  OE1 . GLU A 1 250 ? -45.928 32.533  -21.334 1.00 80.95  ?  250 GLU A OE1 1 
ATOM   1812 O  OE2 . GLU A 1 250 ? -46.986 31.319  -22.839 1.00 78.39  ?  250 GLU A OE2 1 
ATOM   1813 N  N   . TYR A 1 251 ? -41.567 28.669  -22.093 1.00 68.27  ?  251 TYR A N   1 
ATOM   1814 C  CA  . TYR A 1 251 ? -40.331 28.742  -21.266 1.00 66.94  ?  251 TYR A CA  1 
ATOM   1815 C  C   . TYR A 1 251 ? -39.108 28.867  -22.187 1.00 66.18  ?  251 TYR A C   1 
ATOM   1816 O  O   . TYR A 1 251 ? -38.267 29.758  -21.950 1.00 65.51  ?  251 TYR A O   1 
ATOM   1817 C  CB  . TYR A 1 251 ? -40.201 27.524  -20.341 1.00 66.61  ?  251 TYR A CB  1 
ATOM   1818 C  CG  . TYR A 1 251 ? -39.420 27.781  -19.076 1.00 65.96  ?  251 TYR A CG  1 
ATOM   1819 C  CD1 . TYR A 1 251 ? -38.073 28.111  -19.114 1.00 67.11  ?  251 TYR A CD1 1 
ATOM   1820 C  CD2 . TYR A 1 251 ? -40.027 27.702  -17.834 1.00 67.07  ?  251 TYR A CD2 1 
ATOM   1821 C  CE1 . TYR A 1 251 ? -37.352 28.364  -17.957 1.00 65.30  ?  251 TYR A CE1 1 
ATOM   1822 C  CE2 . TYR A 1 251 ? -39.322 27.947  -16.666 1.00 67.71  ?  251 TYR A CE2 1 
ATOM   1823 C  CZ  . TYR A 1 251 ? -37.981 28.281  -16.727 1.00 66.10  ?  251 TYR A CZ  1 
ATOM   1824 O  OH  . TYR A 1 251 ? -37.288 28.524  -15.577 1.00 65.38  ?  251 TYR A OH  1 
ATOM   1825 N  N   . LEU A 1 252 ? -39.010 28.003  -23.203 1.00 63.85  ?  252 LEU A N   1 
ATOM   1826 C  CA  . LEU A 1 252 ? -37.860 27.969  -24.151 1.00 65.47  ?  252 LEU A CA  1 
ATOM   1827 C  C   . LEU A 1 252 ? -37.839 29.253  -24.985 1.00 69.09  ?  252 LEU A C   1 
ATOM   1828 O  O   . LEU A 1 252 ? -36.727 29.760  -25.252 1.00 70.12  ?  252 LEU A O   1 
ATOM   1829 C  CB  . LEU A 1 252 ? -37.965 26.737  -25.055 1.00 63.34  ?  252 LEU A CB  1 
ATOM   1830 C  CG  . LEU A 1 252 ? -37.776 25.388  -24.363 1.00 62.51  ?  252 LEU A CG  1 
ATOM   1831 C  CD1 . LEU A 1 252 ? -37.921 24.251  -25.362 1.00 62.31  ?  252 LEU A CD1 1 
ATOM   1832 C  CD2 . LEU A 1 252 ? -36.427 25.310  -23.663 1.00 63.07  ?  252 LEU A CD2 1 
ATOM   1833 N  N   . ARG A 1 253 ? -39.019 29.743  -25.388 1.00 70.91  ?  253 ARG A N   1 
ATOM   1834 C  CA  A ARG A 1 253 ? -39.155 30.972  -26.218 0.50 71.86  ?  253 ARG A CA  1 
ATOM   1835 C  CA  B ARG A 1 253 ? -39.163 30.974  -26.215 0.50 70.53  ?  253 ARG A CA  1 
ATOM   1836 C  C   . ARG A 1 253 ? -38.664 32.181  -25.412 1.00 68.88  ?  253 ARG A C   1 
ATOM   1837 O  O   . ARG A 1 253 ? -37.973 33.030  -26.004 1.00 67.68  ?  253 ARG A O   1 
ATOM   1838 C  CB  A ARG A 1 253 ? -40.602 31.162  -26.687 0.50 76.25  ?  253 ARG A CB  1 
ATOM   1839 C  CB  B ARG A 1 253 ? -40.615 31.172  -26.663 0.50 73.02  ?  253 ARG A CB  1 
ATOM   1840 C  CG  A ARG A 1 253 ? -41.070 30.113  -27.686 0.50 79.92  ?  253 ARG A CG  1 
ATOM   1841 C  CG  B ARG A 1 253 ? -41.059 30.230  -27.775 0.50 74.71  ?  253 ARG A CG  1 
ATOM   1842 C  CD  A ARG A 1 253 ? -42.363 30.488  -28.391 0.50 82.53  ?  253 ARG A CD  1 
ATOM   1843 C  CD  B ARG A 1 253 ? -42.407 30.597  -28.373 0.50 75.35  ?  253 ARG A CD  1 
ATOM   1844 N  NE  A ARG A 1 253 ? -43.453 30.767  -27.464 0.50 84.51  ?  253 ARG A NE  1 
ATOM   1845 N  NE  B ARG A 1 253 ? -43.532 30.253  -27.512 0.50 75.27  ?  253 ARG A NE  1 
ATOM   1846 C  CZ  A ARG A 1 253 ? -43.999 31.964  -27.277 0.50 83.52  ?  253 ARG A CZ  1 
ATOM   1847 C  CZ  B ARG A 1 253 ? -44.229 29.123  -27.593 0.50 72.50  ?  253 ARG A CZ  1 
ATOM   1848 N  NH1 A ARG A 1 253 ? -44.985 32.113  -26.408 0.50 82.07  ?  253 ARG A NH1 1 
ATOM   1849 N  NH1 B ARG A 1 253 ? -43.914 28.216  -28.500 0.50 72.31  ?  253 ARG A NH1 1 
ATOM   1850 N  NH2 A ARG A 1 253 ? -43.563 33.005  -27.964 0.50 83.15  ?  253 ARG A NH2 1 
ATOM   1851 N  NH2 B ARG A 1 253 ? -45.237 28.905  -26.767 0.50 70.60  ?  253 ARG A NH2 1 
ATOM   1852 N  N   . ASN A 1 254 ? -39.002 32.228  -24.120 1.00 66.56  ?  254 ASN A N   1 
ATOM   1853 C  CA  . ASN A 1 254 ? -38.639 33.336  -23.193 1.00 66.35  ?  254 ASN A CA  1 
ATOM   1854 C  C   . ASN A 1 254 ? -37.123 33.348  -22.959 1.00 64.87  ?  254 ASN A C   1 
ATOM   1855 O  O   . ASN A 1 254 ? -36.581 34.441  -22.700 1.00 64.39  ?  254 ASN A O   1 
ATOM   1856 C  CB  . ASN A 1 254 ? -39.414 33.241  -21.876 1.00 68.06  ?  254 ASN A CB  1 
ATOM   1857 C  CG  . ASN A 1 254 ? -40.912 33.354  -22.068 1.00 70.01  ?  254 ASN A CG  1 
ATOM   1858 O  OD1 . ASN A 1 254 ? -41.381 33.737  -23.137 1.00 74.62  ?  254 ASN A OD1 1 
ATOM   1859 N  ND2 . ASN A 1 254 ? -41.677 33.007  -21.045 1.00 72.46  ?  254 ASN A ND2 1 
ATOM   1860 N  N   . MET A 1 255 ? -36.473 32.181  -23.049 1.00 65.54  ?  255 MET A N   1 
ATOM   1861 C  CA  . MET A 1 255 ? -35.003 32.006  -22.867 1.00 64.34  ?  255 MET A CA  1 
ATOM   1862 C  C   . MET A 1 255 ? -34.254 32.308  -24.169 1.00 61.97  ?  255 MET A C   1 
ATOM   1863 O  O   . MET A 1 255 ? -33.015 32.408  -24.115 1.00 61.82  ?  255 MET A O   1 
ATOM   1864 C  CB  . MET A 1 255 ? -34.666 30.569  -22.464 1.00 64.79  ?  255 MET A CB  1 
ATOM   1865 C  CG  . MET A 1 255 ? -35.031 30.222  -21.044 1.00 65.52  ?  255 MET A CG  1 
ATOM   1866 S  SD  . MET A 1 255 ? -34.739 28.467  -20.735 1.00 64.59  ?  255 MET A SD  1 
ATOM   1867 C  CE  . MET A 1 255 ? -32.958 28.401  -20.920 1.00 65.92  ?  255 MET A CE  1 
ATOM   1868 N  N   . GLY A 1 256 ? -34.966 32.394  -25.295 1.00 61.51  ?  256 GLY A N   1 
ATOM   1869 C  CA  . GLY A 1 256 ? -34.368 32.554  -26.635 1.00 63.50  ?  256 GLY A CA  1 
ATOM   1870 C  C   . GLY A 1 256 ? -33.919 31.220  -27.209 1.00 64.41  ?  256 GLY A C   1 
ATOM   1871 O  O   . GLY A 1 256 ? -33.081 31.221  -28.137 1.00 67.12  ?  256 GLY A O   1 
ATOM   1872 N  N   . VAL A 1 257 ? -34.458 30.119  -26.680 1.00 63.20  ?  257 VAL A N   1 
ATOM   1873 C  CA  . VAL A 1 257 ? -34.151 28.732  -27.138 1.00 63.95  ?  257 VAL A CA  1 
ATOM   1874 C  C   . VAL A 1 257 ? -35.239 28.321  -28.136 1.00 65.03  ?  257 VAL A C   1 
ATOM   1875 O  O   . VAL A 1 257 ? -36.432 28.392  -27.777 1.00 67.76  ?  257 VAL A O   1 
ATOM   1876 C  CB  . VAL A 1 257 ? -34.038 27.754  -25.950 1.00 61.83  ?  257 VAL A CB  1 
ATOM   1877 C  CG1 . VAL A 1 257 ? -33.785 26.323  -26.402 1.00 60.53  ?  257 VAL A CG1 1 
ATOM   1878 C  CG2 . VAL A 1 257 ? -32.959 28.195  -24.971 1.00 61.72  ?  257 VAL A CG2 1 
ATOM   1879 N  N   . ALA A 1 258 ? -34.825 27.932  -29.344 1.00 64.03  ?  258 ALA A N   1 
ATOM   1880 C  CA  . ALA A 1 258 ? -35.697 27.571  -30.486 1.00 63.66  ?  258 ALA A CA  1 
ATOM   1881 C  C   . ALA A 1 258 ? -35.824 26.052  -30.574 1.00 64.22  ?  258 ALA A C   1 
ATOM   1882 O  O   . ALA A 1 258 ? -36.918 25.568  -30.907 1.00 67.40  ?  258 ALA A O   1 
ATOM   1883 C  CB  . ALA A 1 258 ? -35.124 28.131  -31.764 1.00 66.88  ?  258 ALA A CB  1 
ATOM   1884 N  N   . ALA A 1 259 ? -34.726 25.338  -30.324 1.00 64.78  ?  259 ALA A N   1 
ATOM   1885 C  CA  . ALA A 1 259 ? -34.653 23.859  -30.374 1.00 63.53  ?  259 ALA A CA  1 
ATOM   1886 C  C   . ALA A 1 259 ? -33.997 23.330  -29.098 1.00 61.17  ?  259 ALA A C   1 
ATOM   1887 O  O   . ALA A 1 259 ? -33.219 24.072  -28.468 1.00 59.94  ?  259 ALA A O   1 
ATOM   1888 C  CB  . ALA A 1 259 ? -33.900 23.417  -31.605 1.00 62.98  ?  259 ALA A CB  1 
ATOM   1889 N  N   . SER A 1 260 ? -34.309 22.083  -28.748 1.00 60.77  ?  260 SER A N   1 
ATOM   1890 C  CA  . SER A 1 260 ? -33.724 21.367  -27.585 1.00 58.47  ?  260 SER A CA  1 
ATOM   1891 C  C   . SER A 1 260 ? -33.542 19.881  -27.907 1.00 56.53  ?  260 SER A C   1 
ATOM   1892 O  O   . SER A 1 260 ? -34.235 19.376  -28.808 1.00 55.83  ?  260 SER A O   1 
ATOM   1893 C  CB  . SER A 1 260 ? -34.583 21.542  -26.361 1.00 59.55  ?  260 SER A CB  1 
ATOM   1894 O  OG  . SER A 1 260 ? -35.596 20.546  -26.314 1.00 62.96  ?  260 SER A OG  1 
ATOM   1895 N  N   . MET A 1 261 ? -32.603 19.237  -27.214 1.00 55.96  ?  261 MET A N   1 
ATOM   1896 C  CA  A MET A 1 261 ? -32.488 17.756  -27.136 0.50 56.64  ?  261 MET A CA  1 
ATOM   1897 C  CA  B MET A 1 261 ? -32.490 17.756  -27.140 0.50 57.63  ?  261 MET A CA  1 
ATOM   1898 C  C   . MET A 1 261 ? -32.035 17.386  -25.723 1.00 56.27  ?  261 MET A C   1 
ATOM   1899 O  O   . MET A 1 261 ? -31.056 17.985  -25.253 1.00 59.01  ?  261 MET A O   1 
ATOM   1900 C  CB  A MET A 1 261 ? -31.485 17.197  -28.147 0.50 57.78  ?  261 MET A CB  1 
ATOM   1901 C  CB  B MET A 1 261 ? -31.528 17.212  -28.206 0.50 60.09  ?  261 MET A CB  1 
ATOM   1902 C  CG  A MET A 1 261 ? -31.342 15.685  -28.071 0.50 58.69  ?  261 MET A CG  1 
ATOM   1903 C  CG  B MET A 1 261 ? -30.154 16.784  -27.704 0.50 62.77  ?  261 MET A CG  1 
ATOM   1904 S  SD  A MET A 1 261 ? -29.908 15.071  -28.979 0.50 59.99  ?  261 MET A SD  1 
ATOM   1905 S  SD  B MET A 1 261 ? -30.119 15.052  -27.178 0.50 64.35  ?  261 MET A SD  1 
ATOM   1906 C  CE  A MET A 1 261 ? -28.592 15.517  -27.848 0.50 59.85  ?  261 MET A CE  1 
ATOM   1907 C  CE  B MET A 1 261 ? -30.525 14.252  -28.730 0.50 65.09  ?  261 MET A CE  1 
ATOM   1908 N  N   . SER A 1 262 ? -32.746 16.465  -25.076 1.00 55.77  ?  262 SER A N   1 
ATOM   1909 C  CA  . SER A 1 262 ? -32.433 16.017  -23.693 1.00 56.92  ?  262 SER A CA  1 
ATOM   1910 C  C   . SER A 1 262 ? -32.158 14.511  -23.695 1.00 54.98  ?  262 SER A C   1 
ATOM   1911 O  O   . SER A 1 262 ? -32.845 13.787  -24.432 1.00 54.34  ?  262 SER A O   1 
ATOM   1912 C  CB  . SER A 1 262 ? -33.520 16.394  -22.722 1.00 57.41  ?  262 SER A CB  1 
ATOM   1913 O  OG  . SER A 1 262 ? -34.663 15.577  -22.907 1.00 63.40  ?  262 SER A OG  1 
ATOM   1914 N  N   . ILE A 1 263 ? -31.160 14.084  -22.920 1.00 52.16  ?  263 ILE A N   1 
ATOM   1915 C  CA  . ILE A 1 263 ? -30.791 12.654  -22.712 1.00 52.59  ?  263 ILE A CA  1 
ATOM   1916 C  C   . ILE A 1 263 ? -31.017 12.331  -21.234 1.00 50.35  ?  263 ILE A C   1 
ATOM   1917 O  O   . ILE A 1 263 ? -30.527 13.091  -20.380 1.00 49.08  ?  263 ILE A O   1 
ATOM   1918 C  CB  . ILE A 1 263 ? -29.340 12.384  -23.159 1.00 56.03  ?  263 ILE A CB  1 
ATOM   1919 C  CG1 . ILE A 1 263 ? -29.109 12.842  -24.603 1.00 57.00  ?  263 ILE A CG1 1 
ATOM   1920 C  CG2 . ILE A 1 263 ? -28.971 10.919  -22.959 1.00 56.39  ?  263 ILE A CG2 1 
ATOM   1921 C  CD1 . ILE A 1 263 ? -27.695 12.668  -25.097 1.00 57.79  ?  263 ILE A CD1 1 
ATOM   1922 N  N   . SER A 1 264 ? -31.761 11.258  -20.963 1.00 50.06  ?  264 SER A N   1 
ATOM   1923 C  CA  . SER A 1 264 ? -32.036 10.751  -19.592 1.00 49.15  ?  264 SER A CA  1 
ATOM   1924 C  C   . SER A 1 264 ? -30.789 10.047  -19.059 1.00 48.72  ?  264 SER A C   1 
ATOM   1925 O  O   . SER A 1 264 ? -30.287 9.141   -19.749 1.00 49.41  ?  264 SER A O   1 
ATOM   1926 C  CB  . SER A 1 264 ? -33.224 9.837   -19.560 1.00 48.86  ?  264 SER A CB  1 
ATOM   1927 O  OG  . SER A 1 264 ? -34.404 10.568  -19.834 1.00 50.87  ?  264 SER A OG  1 
ATOM   1928 N  N   . VAL A 1 265 ? -30.301 10.490  -17.900 1.00 47.03  ?  265 VAL A N   1 
ATOM   1929 C  CA  . VAL A 1 265 ? -29.200 9.830   -17.144 1.00 47.48  ?  265 VAL A CA  1 
ATOM   1930 C  C   . VAL A 1 265 ? -29.859 8.927   -16.102 1.00 48.60  ?  265 VAL A C   1 
ATOM   1931 O  O   . VAL A 1 265 ? -30.390 9.450   -15.102 1.00 46.25  ?  265 VAL A O   1 
ATOM   1932 C  CB  . VAL A 1 265 ? -28.244 10.853  -16.504 1.00 47.92  ?  265 VAL A CB  1 
ATOM   1933 C  CG1 . VAL A 1 265 ? -27.112 10.167  -15.753 1.00 48.10  ?  265 VAL A CG1 1 
ATOM   1934 C  CG2 . VAL A 1 265 ? -27.695 11.827  -17.537 1.00 47.29  ?  265 VAL A CG2 1 
ATOM   1935 N  N   . ILE A 1 266 ? -29.855 7.623   -16.360 1.00 51.50  ?  266 ILE A N   1 
ATOM   1936 C  CA  . ILE A 1 266 ? -30.496 6.600   -15.487 1.00 54.72  ?  266 ILE A CA  1 
ATOM   1937 C  C   . ILE A 1 266 ? -29.398 5.900   -14.682 1.00 55.32  ?  266 ILE A C   1 
ATOM   1938 O  O   . ILE A 1 266 ? -28.521 5.268   -15.298 1.00 57.82  ?  266 ILE A O   1 
ATOM   1939 C  CB  . ILE A 1 266 ? -31.344 5.634   -16.334 1.00 54.73  ?  266 ILE A CB  1 
ATOM   1940 C  CG1 . ILE A 1 266 ? -32.473 6.384   -17.047 1.00 55.57  ?  266 ILE A CG1 1 
ATOM   1941 C  CG2 . ILE A 1 266 ? -31.870 4.489   -15.483 1.00 55.21  ?  266 ILE A CG2 1 
ATOM   1942 C  CD1 . ILE A 1 266 ? -33.092 5.621   -18.192 1.00 58.58  ?  266 ILE A CD1 1 
ATOM   1943 N  N   . VAL A 1 267 ? -29.451 6.035   -13.357 1.00 55.03  ?  267 VAL A N   1 
ATOM   1944 C  CA  . VAL A 1 267 ? -28.465 5.459   -12.398 1.00 56.46  ?  267 VAL A CA  1 
ATOM   1945 C  C   . VAL A 1 267 ? -29.243 4.690   -11.327 1.00 60.22  ?  267 VAL A C   1 
ATOM   1946 O  O   . VAL A 1 267 ? -30.114 5.310   -10.677 1.00 58.43  ?  267 VAL A O   1 
ATOM   1947 C  CB  . VAL A 1 267 ? -27.589 6.560   -11.774 1.00 56.56  ?  267 VAL A CB  1 
ATOM   1948 C  CG1 . VAL A 1 267 ? -26.494 5.974   -10.900 1.00 58.15  ?  267 VAL A CG1 1 
ATOM   1949 C  CG2 . VAL A 1 267 ? -26.998 7.479   -12.832 1.00 57.63  ?  267 VAL A CG2 1 
ATOM   1950 N  N   . ASP A 1 268 ? -28.941 3.397   -11.161 1.00 64.21  ?  268 ASP A N   1 
ATOM   1951 C  CA  . ASP A 1 268 ? -29.642 2.485   -10.215 1.00 65.83  ?  268 ASP A CA  1 
ATOM   1952 C  C   . ASP A 1 268 ? -31.149 2.540   -10.505 1.00 65.78  ?  268 ASP A C   1 
ATOM   1953 O  O   . ASP A 1 268 ? -31.939 2.643   -9.547  1.00 66.89  ?  268 ASP A O   1 
ATOM   1954 C  CB  . ASP A 1 268 ? -29.302 2.845   -8.765  1.00 67.07  ?  268 ASP A CB  1 
ATOM   1955 C  CG  . ASP A 1 268 ? -27.810 2.848   -8.468  1.00 67.38  ?  268 ASP A CG  1 
ATOM   1956 O  OD1 . ASP A 1 268 ? -27.109 1.952   -8.984  1.00 67.32  ?  268 ASP A OD1 1 
ATOM   1957 O  OD2 . ASP A 1 268 ? -27.360 3.751   -7.729  1.00 65.50  ?  268 ASP A OD2 1 
ATOM   1958 N  N   . ASP A 1 269 ? -31.513 2.520   -11.792 1.00 68.41  ?  269 ASP A N   1 
ATOM   1959 C  CA  . ASP A 1 269 ? -32.905 2.441   -12.317 1.00 68.73  ?  269 ASP A CA  1 
ATOM   1960 C  C   . ASP A 1 269 ? -33.730 3.664   -11.885 1.00 66.46  ?  269 ASP A C   1 
ATOM   1961 O  O   . ASP A 1 269 ? -34.970 3.600   -11.980 1.00 70.93  ?  269 ASP A O   1 
ATOM   1962 C  CB  . ASP A 1 269 ? -33.553 1.118   -11.904 1.00 72.21  ?  269 ASP A CB  1 
ATOM   1963 C  CG  . ASP A 1 269 ? -32.912 -0.088  -12.568 1.00 73.69  ?  269 ASP A CG  1 
ATOM   1964 O  OD1 . ASP A 1 269 ? -32.958 -0.159  -13.812 1.00 73.80  ?  269 ASP A OD1 1 
ATOM   1965 O  OD2 . ASP A 1 269 ? -32.357 -0.935  -11.838 1.00 75.20  ?  269 ASP A OD2 1 
ATOM   1966 N  N   . ALA A 1 270 ? -33.073 4.749   -11.468 1.00 63.88  ?  270 ALA A N   1 
ATOM   1967 C  CA  . ALA A 1 270 ? -33.713 6.038   -11.113 1.00 62.17  ?  270 ALA A CA  1 
ATOM   1968 C  C   . ALA A 1 270 ? -33.255 7.116   -12.098 1.00 60.84  ?  270 ALA A C   1 
ATOM   1969 O  O   . ALA A 1 270 ? -32.154 6.981   -12.661 1.00 59.14  ?  270 ALA A O   1 
ATOM   1970 C  CB  . ALA A 1 270 ? -33.376 6.420   -9.693  1.00 61.77  ?  270 ALA A CB  1 
ATOM   1971 N  N   . LEU A 1 271 ? -34.085 8.139   -12.300 1.00 59.79  ?  271 LEU A N   1 
ATOM   1972 C  CA  . LEU A 1 271 ? -33.733 9.335   -13.104 1.00 56.14  ?  271 LEU A CA  1 
ATOM   1973 C  C   . LEU A 1 271 ? -32.806 10.210  -12.257 1.00 53.05  ?  271 LEU A C   1 
ATOM   1974 O  O   . LEU A 1 271 ? -33.305 10.912  -11.358 1.00 52.29  ?  271 LEU A O   1 
ATOM   1975 C  CB  . LEU A 1 271 ? -35.010 10.075  -13.513 1.00 55.05  ?  271 LEU A CB  1 
ATOM   1976 C  CG  . LEU A 1 271 ? -34.801 11.265  -14.445 1.00 57.54  ?  271 LEU A CG  1 
ATOM   1977 C  CD1 . LEU A 1 271 ? -34.271 10.812  -15.798 1.00 59.99  ?  271 LEU A CD1 1 
ATOM   1978 C  CD2 . LEU A 1 271 ? -36.093 12.048  -14.617 1.00 58.37  ?  271 LEU A CD2 1 
ATOM   1979 N  N   . TRP A 1 272 ? -31.501 10.124  -12.520 1.00 50.07  ?  272 TRP A N   1 
ATOM   1980 C  CA  . TRP A 1 272 ? -30.435 10.875  -11.805 1.00 49.82  ?  272 TRP A CA  1 
ATOM   1981 C  C   . TRP A 1 272 ? -30.450 12.340  -12.244 1.00 49.14  ?  272 TRP A C   1 
ATOM   1982 O  O   . TRP A 1 272 ? -30.135 13.212  -11.412 1.00 51.11  ?  272 TRP A O   1 
ATOM   1983 C  CB  . TRP A 1 272 ? -29.070 10.231  -12.066 1.00 50.49  ?  272 TRP A CB  1 
ATOM   1984 C  CG  . TRP A 1 272 ? -27.899 10.976  -11.505 1.00 49.75  ?  272 TRP A CG  1 
ATOM   1985 C  CD1 . TRP A 1 272 ? -27.303 10.776  -10.295 1.00 48.83  ?  272 TRP A CD1 1 
ATOM   1986 C  CD2 . TRP A 1 272 ? -27.154 12.024  -12.149 1.00 49.60  ?  272 TRP A CD2 1 
ATOM   1987 N  NE1 . TRP A 1 272 ? -26.247 11.631  -10.138 1.00 49.54  ?  272 TRP A NE1 1 
ATOM   1988 C  CE2 . TRP A 1 272 ? -26.129 12.408  -11.259 1.00 49.67  ?  272 TRP A CE2 1 
ATOM   1989 C  CE3 . TRP A 1 272 ? -27.254 12.676  -13.384 1.00 50.45  ?  272 TRP A CE3 1 
ATOM   1990 C  CZ2 . TRP A 1 272 ? -25.213 13.412  -11.570 1.00 50.13  ?  272 TRP A CZ2 1 
ATOM   1991 C  CZ3 . TRP A 1 272 ? -26.350 13.670  -13.688 1.00 50.47  ?  272 TRP A CZ3 1 
ATOM   1992 C  CH2 . TRP A 1 272 ? -25.347 14.034  -12.790 1.00 50.16  ?  272 TRP A CH2 1 
ATOM   1993 N  N   . GLY A 1 273 ? -30.794 12.588  -13.508 1.00 47.79  ?  273 GLY A N   1 
ATOM   1994 C  CA  . GLY A 1 273 ? -30.704 13.923  -14.126 1.00 48.01  ?  273 GLY A CA  1 
ATOM   1995 C  C   . GLY A 1 273 ? -30.780 13.852  -15.638 1.00 48.22  ?  273 GLY A C   1 
ATOM   1996 O  O   . GLY A 1 273 ? -31.051 12.755  -16.169 1.00 49.01  ?  273 GLY A O   1 
ATOM   1997 N  N   . LEU A 1 274 ? -30.555 14.986  -16.304 1.00 47.89  ?  274 LEU A N   1 
ATOM   1998 C  CA  . LEU A 1 274 ? -30.654 15.121  -17.779 1.00 49.10  ?  274 LEU A CA  1 
ATOM   1999 C  C   . LEU A 1 274 ? -29.388 15.781  -18.320 1.00 48.12  ?  274 LEU A C   1 
ATOM   2000 O  O   . LEU A 1 274 ? -28.918 16.744  -17.689 1.00 48.69  ?  274 LEU A O   1 
ATOM   2001 C  CB  . LEU A 1 274 ? -31.875 15.978  -18.125 1.00 51.39  ?  274 LEU A CB  1 
ATOM   2002 C  CG  . LEU A 1 274 ? -33.207 15.528  -17.532 1.00 52.75  ?  274 LEU A CG  1 
ATOM   2003 C  CD1 . LEU A 1 274 ? -34.290 16.551  -17.840 1.00 53.37  ?  274 LEU A CD1 1 
ATOM   2004 C  CD2 . LEU A 1 274 ? -33.604 14.156  -18.057 1.00 53.72  ?  274 LEU A CD2 1 
ATOM   2005 N  N   . ILE A 1 275 ? -28.861 15.269  -19.434 1.00 47.89  ?  275 ILE A N   1 
ATOM   2006 C  CA  . ILE A 1 275 ? -28.004 16.053  -20.373 1.00 49.00  ?  275 ILE A CA  1 
ATOM   2007 C  C   . ILE A 1 275 ? -28.976 16.819  -21.277 1.00 50.08  ?  275 ILE A C   1 
ATOM   2008 O  O   . ILE A 1 275 ? -29.731 16.153  -22.005 1.00 50.32  ?  275 ILE A O   1 
ATOM   2009 C  CB  . ILE A 1 275 ? -27.052 15.158  -21.196 1.00 48.74  ?  275 ILE A CB  1 
ATOM   2010 C  CG1 . ILE A 1 275 ? -26.220 14.215  -20.323 1.00 47.38  ?  275 ILE A CG1 1 
ATOM   2011 C  CG2 . ILE A 1 275 ? -26.164 16.014  -22.088 1.00 50.87  ?  275 ILE A CG2 1 
ATOM   2012 C  CD1 . ILE A 1 275 ? -25.450 13.178  -21.106 1.00 47.28  ?  275 ILE A CD1 1 
ATOM   2013 N  N   . VAL A 1 276 ? -28.991 18.152  -21.207 1.00 50.24  ?  276 VAL A N   1 
ATOM   2014 C  CA  . VAL A 1 276 ? -29.948 18.994  -21.983 1.00 52.30  ?  276 VAL A CA  1 
ATOM   2015 C  C   . VAL A 1 276 ? -29.165 19.920  -22.911 1.00 52.40  ?  276 VAL A C   1 
ATOM   2016 O  O   . VAL A 1 276 ? -28.350 20.715  -22.411 1.00 54.48  ?  276 VAL A O   1 
ATOM   2017 C  CB  . VAL A 1 276 ? -30.884 19.784  -21.055 1.00 56.44  ?  276 VAL A CB  1 
ATOM   2018 C  CG1 . VAL A 1 276 ? -31.970 20.503  -21.840 1.00 58.72  ?  276 VAL A CG1 1 
ATOM   2019 C  CG2 . VAL A 1 276 ? -31.496 18.874  -20.006 1.00 59.00  ?  276 VAL A CG2 1 
ATOM   2020 N  N   . CYS A 1 277 ? -29.431 19.806  -24.212 1.00 51.97  ?  277 CYS A N   1 
ATOM   2021 C  CA  . CYS A 1 277 ? -28.833 20.640  -25.287 1.00 53.25  ?  277 CYS A CA  1 
ATOM   2022 C  C   . CYS A 1 277 ? -29.852 21.678  -25.759 1.00 53.49  ?  277 CYS A C   1 
ATOM   2023 O  O   . CYS A 1 277 ? -30.959 21.275  -26.132 1.00 54.49  ?  277 CYS A O   1 
ATOM   2024 C  CB  . CYS A 1 277 ? -28.397 19.778  -26.463 1.00 53.54  ?  277 CYS A CB  1 
ATOM   2025 S  SG  . CYS A 1 277 ? -27.423 18.339  -25.958 1.00 55.76  ?  277 CYS A SG  1 
ATOM   2026 N  N   . HIS A 1 278 ? -29.475 22.958  -25.727 1.00 57.04  ?  278 HIS A N   1 
ATOM   2027 C  CA  . HIS A 1 278 ? -30.283 24.108  -26.212 1.00 57.26  ?  278 HIS A CA  1 
ATOM   2028 C  C   . HIS A 1 278 ? -29.640 24.687  -27.474 1.00 58.30  ?  278 HIS A C   1 
ATOM   2029 O  O   . HIS A 1 278 ? -28.402 24.827  -27.496 1.00 57.81  ?  278 HIS A O   1 
ATOM   2030 C  CB  . HIS A 1 278 ? -30.400 25.202  -25.144 1.00 56.93  ?  278 HIS A CB  1 
ATOM   2031 C  CG  . HIS A 1 278 ? -31.264 24.850  -23.985 1.00 57.60  ?  278 HIS A CG  1 
ATOM   2032 N  ND1 . HIS A 1 278 ? -31.164 25.513  -22.778 1.00 60.46  ?  278 HIS A ND1 1 
ATOM   2033 C  CD2 . HIS A 1 278 ? -32.231 23.919  -23.835 1.00 57.98  ?  278 HIS A CD2 1 
ATOM   2034 C  CE1 . HIS A 1 278 ? -32.039 25.010  -21.933 1.00 60.45  ?  278 HIS A CE1 1 
ATOM   2035 N  NE2 . HIS A 1 278 ? -32.707 24.027  -22.555 1.00 59.62  ?  278 HIS A NE2 1 
ATOM   2036 N  N   . HIS A 1 279 ? -30.463 25.025  -28.466 1.00 61.28  ?  279 HIS A N   1 
ATOM   2037 C  CA  . HIS A 1 279 ? -30.057 25.754  -29.697 1.00 62.14  ?  279 HIS A CA  1 
ATOM   2038 C  C   . HIS A 1 279 ? -30.928 27.005  -29.830 1.00 61.80  ?  279 HIS A C   1 
ATOM   2039 O  O   . HIS A 1 279 ? -32.127 26.926  -29.490 1.00 61.68  ?  279 HIS A O   1 
ATOM   2040 C  CB  . HIS A 1 279 ? -30.142 24.829  -30.916 1.00 62.79  ?  279 HIS A CB  1 
ATOM   2041 C  CG  . HIS A 1 279 ? -29.071 25.070  -31.924 1.00 67.24  ?  279 HIS A CG  1 
ATOM   2042 N  ND1 . HIS A 1 279 ? -27.737 25.141  -31.577 1.00 70.32  ?  279 HIS A ND1 1 
ATOM   2043 C  CD2 . HIS A 1 279 ? -29.124 25.237  -33.264 1.00 70.23  ?  279 HIS A CD2 1 
ATOM   2044 C  CE1 . HIS A 1 279 ? -27.014 25.347  -32.658 1.00 71.53  ?  279 HIS A CE1 1 
ATOM   2045 N  NE2 . HIS A 1 279 ? -27.841 25.405  -33.707 1.00 71.43  ?  279 HIS A NE2 1 
ATOM   2046 N  N   . CYS A 1 280 ? -30.331 28.116  -30.272 1.00 63.05  ?  280 CYS A N   1 
ATOM   2047 C  CA  . CYS A 1 280 ? -31.008 29.432  -30.460 1.00 64.67  ?  280 CYS A CA  1 
ATOM   2048 C  C   . CYS A 1 280 ? -31.731 29.479  -31.813 1.00 63.48  ?  280 CYS A C   1 
ATOM   2049 O  O   . CYS A 1 280 ? -32.611 30.343  -31.987 1.00 64.49  ?  280 CYS A O   1 
ATOM   2050 C  CB  . CYS A 1 280 ? -29.998 30.563  -30.331 1.00 63.58  ?  280 CYS A CB  1 
ATOM   2051 S  SG  . CYS A 1 280 ? -29.210 30.596  -28.700 1.00 64.56  ?  280 CYS A SG  1 
ATOM   2052 N  N   . SER A 1 281 ? -31.360 28.578  -32.722 1.00 63.16  ?  281 SER A N   1 
ATOM   2053 C  CA  A SER A 1 281 ? -32.000 28.383  -34.051 0.50 63.59  ?  281 SER A CA  1 
ATOM   2054 C  CA  B SER A 1 281 ? -32.015 28.392  -34.044 0.50 62.60  ?  281 SER A CA  1 
ATOM   2055 C  C   . SER A 1 281 ? -32.720 27.037  -34.072 1.00 63.00  ?  281 SER A C   1 
ATOM   2056 O  O   . SER A 1 281 ? -32.348 26.131  -33.330 1.00 60.69  ?  281 SER A O   1 
ATOM   2057 C  CB  A SER A 1 281 ? -30.963 28.483  -35.149 0.50 64.57  ?  281 SER A CB  1 
ATOM   2058 C  CB  B SER A 1 281 ? -31.012 28.530  -35.166 0.50 62.48  ?  281 SER A CB  1 
ATOM   2059 O  OG  A SER A 1 281 ? -31.353 27.759  -36.308 0.50 66.31  ?  281 SER A OG  1 
ATOM   2060 O  OG  B SER A 1 281 ? -29.755 27.975  -34.805 0.50 61.57  ?  281 SER A OG  1 
ATOM   2061 N  N   . PRO A 1 282 ? -33.769 26.853  -34.913 1.00 63.36  ?  282 PRO A N   1 
ATOM   2062 C  CA  . PRO A 1 282 ? -34.383 25.535  -35.084 1.00 63.58  ?  282 PRO A CA  1 
ATOM   2063 C  C   . PRO A 1 282 ? -33.326 24.477  -35.423 1.00 63.49  ?  282 PRO A C   1 
ATOM   2064 O  O   . PRO A 1 282 ? -32.348 24.822  -36.058 1.00 66.39  ?  282 PRO A O   1 
ATOM   2065 C  CB  . PRO A 1 282 ? -35.356 25.733  -36.254 1.00 62.62  ?  282 PRO A CB  1 
ATOM   2066 C  CG  . PRO A 1 282 ? -35.719 27.199  -36.168 1.00 64.09  ?  282 PRO A CG  1 
ATOM   2067 C  CD  . PRO A 1 282 ? -34.440 27.882  -35.725 1.00 63.87  ?  282 PRO A CD  1 
ATOM   2068 N  N   . ARG A 1 283 ? -33.536 23.232  -34.991 1.00 64.51  ?  283 ARG A N   1 
ATOM   2069 C  CA  . ARG A 1 283 ? -32.525 22.155  -35.175 1.00 68.29  ?  283 ARG A CA  1 
ATOM   2070 C  C   . ARG A 1 283 ? -33.181 20.777  -35.051 1.00 69.61  ?  283 ARG A C   1 
ATOM   2071 O  O   . ARG A 1 283 ? -33.746 20.473  -33.986 1.00 71.42  ?  283 ARG A O   1 
ATOM   2072 C  CB  . ARG A 1 283 ? -31.380 22.315  -34.170 1.00 69.66  ?  283 ARG A CB  1 
ATOM   2073 C  CG  . ARG A 1 283 ? -30.152 21.481  -34.502 1.00 71.27  ?  283 ARG A CG  1 
ATOM   2074 C  CD  . ARG A 1 283 ? -28.994 21.743  -33.561 1.00 74.95  ?  283 ARG A CD  1 
ATOM   2075 N  NE  . ARG A 1 283 ? -27.896 20.828  -33.840 1.00 76.74  ?  283 ARG A NE  1 
ATOM   2076 C  CZ  . ARG A 1 283 ? -26.952 21.020  -34.756 1.00 79.27  ?  283 ARG A CZ  1 
ATOM   2077 N  NH1 . ARG A 1 283 ? -26.937 22.120  -35.493 1.00 82.77  ?  283 ARG A NH1 1 
ATOM   2078 N  NH2 . ARG A 1 283 ? -26.016 20.106  -34.932 1.00 81.12  ?  283 ARG A NH2 1 
ATOM   2079 N  N   . VAL A 1 284 ? -33.092 19.990  -36.124 1.00 73.68  ?  284 VAL A N   1 
ATOM   2080 C  CA  . VAL A 1 284 ? -33.454 18.544  -36.176 1.00 78.23  ?  284 VAL A CA  1 
ATOM   2081 C  C   . VAL A 1 284 ? -32.148 17.752  -36.236 1.00 79.06  ?  284 VAL A C   1 
ATOM   2082 O  O   . VAL A 1 284 ? -31.297 18.093  -37.077 1.00 85.26  ?  284 VAL A O   1 
ATOM   2083 C  CB  . VAL A 1 284 ? -34.337 18.226  -37.401 1.00 82.42  ?  284 VAL A CB  1 
ATOM   2084 C  CG1 . VAL A 1 284 ? -34.785 16.771  -37.424 1.00 83.50  ?  284 VAL A CG1 1 
ATOM   2085 C  CG2 . VAL A 1 284 ? -35.538 19.155  -37.496 1.00 84.14  ?  284 VAL A CG2 1 
ATOM   2086 N  N   . LEU A 1 285 ? -31.993 16.743  -35.381 1.00 79.84  ?  285 LEU A N   1 
ATOM   2087 C  CA  . LEU A 1 285 ? -30.945 15.703  -35.547 1.00 77.87  ?  285 LEU A CA  1 
ATOM   2088 C  C   . LEU A 1 285 ? -31.547 14.535  -36.329 1.00 71.48  ?  285 LEU A C   1 
ATOM   2089 O  O   . LEU A 1 285 ? -32.661 14.096  -35.984 1.00 66.21  ?  285 LEU A O   1 
ATOM   2090 C  CB  . LEU A 1 285 ? -30.434 15.252  -34.177 1.00 83.26  ?  285 LEU A CB  1 
ATOM   2091 C  CG  . LEU A 1 285 ? -29.666 16.306  -33.384 1.00 88.39  ?  285 LEU A CG  1 
ATOM   2092 C  CD1 . LEU A 1 285 ? -29.341 15.780  -31.997 1.00 90.28  ?  285 LEU A CD1 1 
ATOM   2093 C  CD2 . LEU A 1 285 ? -28.394 16.731  -34.107 1.00 89.61  ?  285 LEU A CD2 1 
ATOM   2094 N  N   . SER A 1 286 ? -30.837 14.075  -37.358 1.00 69.10  ?  286 SER A N   1 
ATOM   2095 C  CA  . SER A 1 286 ? -31.215 12.886  -38.167 1.00 68.96  ?  286 SER A CA  1 
ATOM   2096 C  C   . SER A 1 286 ? -31.172 11.632  -37.288 1.00 68.58  ?  286 SER A C   1 
ATOM   2097 O  O   . SER A 1 286 ? -30.415 11.626  -36.302 1.00 73.00  ?  286 SER A O   1 
ATOM   2098 C  CB  . SER A 1 286 ? -30.314 12.748  -39.354 1.00 69.74  ?  286 SER A CB  1 
ATOM   2099 O  OG  . SER A 1 286 ? -28.957 12.697  -38.942 1.00 70.81  ?  286 SER A OG  1 
ATOM   2100 N  N   . MET A 1 287 ? -31.941 10.605  -37.653 1.00 66.94  ?  287 MET A N   1 
ATOM   2101 C  CA  . MET A 1 287 ? -32.066 9.334   -36.887 1.00 67.36  ?  287 MET A CA  1 
ATOM   2102 C  C   . MET A 1 287 ? -30.688 8.776   -36.528 1.00 67.22  ?  287 MET A C   1 
ATOM   2103 O  O   . MET A 1 287 ? -30.466 8.399   -35.380 1.00 68.47  ?  287 MET A O   1 
ATOM   2104 C  CB  . MET A 1 287 ? -32.848 8.291   -37.688 1.00 67.36  ?  287 MET A CB  1 
ATOM   2105 C  CG  . MET A 1 287 ? -32.836 6.916   -37.064 1.00 67.69  ?  287 MET A CG  1 
ATOM   2106 S  SD  . MET A 1 287 ? -34.138 5.876   -37.742 1.00 69.95  ?  287 MET A SD  1 
ATOM   2107 C  CE  . MET A 1 287 ? -35.584 6.722   -37.104 1.00 69.34  ?  287 MET A CE  1 
ATOM   2108 N  N   . PRO A 1 288 ? -29.718 8.690   -37.470 1.00 66.63  ?  288 PRO A N   1 
ATOM   2109 C  CA  . PRO A 1 288 ? -28.414 8.099   -37.163 1.00 66.09  ?  288 PRO A CA  1 
ATOM   2110 C  C   . PRO A 1 288 ? -27.658 8.839   -36.049 1.00 62.94  ?  288 PRO A C   1 
ATOM   2111 O  O   . PRO A 1 288 ? -27.006 8.184   -35.264 1.00 64.49  ?  288 PRO A O   1 
ATOM   2112 C  CB  . PRO A 1 288 ? -27.641 8.197   -38.488 1.00 68.39  ?  288 PRO A CB  1 
ATOM   2113 C  CG  . PRO A 1 288 ? -28.724 8.312   -39.538 1.00 68.94  ?  288 PRO A CG  1 
ATOM   2114 C  CD  . PRO A 1 288 ? -29.803 9.137   -38.869 1.00 67.62  ?  288 PRO A CD  1 
ATOM   2115 N  N   . VAL A 1 289 ? -27.767 10.170  -36.012 1.00 60.40  ?  289 VAL A N   1 
ATOM   2116 C  CA  . VAL A 1 289 ? -27.132 11.034  -34.972 1.00 61.08  ?  289 VAL A CA  1 
ATOM   2117 C  C   . VAL A 1 289 ? -27.853 10.806  -33.638 1.00 60.24  ?  289 VAL A C   1 
ATOM   2118 O  O   . VAL A 1 289 ? -27.157 10.676  -32.618 1.00 64.55  ?  289 VAL A O   1 
ATOM   2119 C  CB  . VAL A 1 289 ? -27.132 12.521  -35.375 1.00 62.13  ?  289 VAL A CB  1 
ATOM   2120 C  CG1 . VAL A 1 289 ? -26.546 13.406  -34.283 1.00 63.00  ?  289 VAL A CG1 1 
ATOM   2121 C  CG2 . VAL A 1 289 ? -26.387 12.740  -36.680 1.00 63.51  ?  289 VAL A CG2 1 
ATOM   2122 N  N   . ARG A 1 290 ? -29.187 10.748  -33.650 1.00 58.10  ?  290 ARG A N   1 
ATOM   2123 C  CA  . ARG A 1 290 ? -30.001 10.462  -32.432 1.00 58.54  ?  290 ARG A CA  1 
ATOM   2124 C  C   . ARG A 1 290 ? -29.605 9.093   -31.864 1.00 57.89  ?  290 ARG A C   1 
ATOM   2125 O  O   . ARG A 1 290 ? -29.438 8.995   -30.638 1.00 58.82  ?  290 ARG A O   1 
ATOM   2126 C  CB  . ARG A 1 290 ? -31.501 10.499  -32.736 1.00 59.99  ?  290 ARG A CB  1 
ATOM   2127 C  CG  . ARG A 1 290 ? -32.041 11.894  -33.017 1.00 61.85  ?  290 ARG A CG  1 
ATOM   2128 C  CD  . ARG A 1 290 ? -33.505 12.047  -32.643 1.00 65.13  ?  290 ARG A CD  1 
ATOM   2129 N  NE  . ARG A 1 290 ? -34.363 11.010  -33.199 1.00 66.91  ?  290 ARG A NE  1 
ATOM   2130 C  CZ  . ARG A 1 290 ? -34.749 10.940  -34.470 1.00 69.10  ?  290 ARG A CZ  1 
ATOM   2131 N  NH1 . ARG A 1 290 ? -34.345 11.849  -35.346 1.00 69.02  ?  290 ARG A NH1 1 
ATOM   2132 N  NH2 . ARG A 1 290 ? -35.528 9.948   -34.866 1.00 70.02  ?  290 ARG A NH2 1 
ATOM   2133 N  N   . ILE A 1 291 ? -29.456 8.076   -32.717 1.00 56.30  ?  291 ILE A N   1 
ATOM   2134 C  CA  . ILE A 1 291 ? -29.049 6.704   -32.289 1.00 57.88  ?  291 ILE A CA  1 
ATOM   2135 C  C   . ILE A 1 291 ? -27.711 6.810   -31.546 1.00 58.44  ?  291 ILE A C   1 
ATOM   2136 O  O   . ILE A 1 291 ? -27.602 6.235   -30.446 1.00 59.31  ?  291 ILE A O   1 
ATOM   2137 C  CB  . ILE A 1 291 ? -28.981 5.733   -33.487 1.00 58.78  ?  291 ILE A CB  1 
ATOM   2138 C  CG1 . ILE A 1 291 ? -30.376 5.395   -34.020 1.00 60.28  ?  291 ILE A CG1 1 
ATOM   2139 C  CG2 . ILE A 1 291 ? -28.209 4.471   -33.123 1.00 59.84  ?  291 ILE A CG2 1 
ATOM   2140 C  CD1 . ILE A 1 291 ? -30.371 4.697   -35.365 1.00 61.38  ?  291 ILE A CD1 1 
ATOM   2141 N  N   . ALA A 1 292 ? -26.738 7.519   -32.126 1.00 56.66  ?  292 ALA A N   1 
ATOM   2142 C  CA  . ALA A 1 292 ? -25.384 7.725   -31.556 1.00 55.65  ?  292 ALA A CA  1 
ATOM   2143 C  C   . ALA A 1 292 ? -25.497 8.391   -30.181 1.00 54.50  ?  292 ALA A C   1 
ATOM   2144 O  O   . ALA A 1 292 ? -24.870 7.891   -29.236 1.00 57.72  ?  292 ALA A O   1 
ATOM   2145 C  CB  . ALA A 1 292 ? -24.534 8.553   -32.487 1.00 55.35  ?  292 ALA A CB  1 
ATOM   2146 N  N   . ALA A 1 293 ? -26.273 9.473   -30.086 1.00 52.32  ?  293 ALA A N   1 
ATOM   2147 C  CA  . ALA A 1 293 ? -26.471 10.276  -28.854 1.00 52.35  ?  293 ALA A CA  1 
ATOM   2148 C  C   . ALA A 1 293 ? -27.108 9.409   -27.762 1.00 52.28  ?  293 ALA A C   1 
ATOM   2149 O  O   . ALA A 1 293 ? -26.707 9.543   -26.595 1.00 54.51  ?  293 ALA A O   1 
ATOM   2150 C  CB  . ALA A 1 293 ? -27.312 11.494  -29.150 1.00 51.98  ?  293 ALA A CB  1 
ATOM   2151 N  N   . ALA A 1 294 ? -28.066 8.559   -28.136 1.00 52.58  ?  294 ALA A N   1 
ATOM   2152 C  CA  . ALA A 1 294 ? -28.790 7.645   -27.220 1.00 53.54  ?  294 ALA A CA  1 
ATOM   2153 C  C   . ALA A 1 294 ? -27.809 6.620   -26.639 1.00 54.69  ?  294 ALA A C   1 
ATOM   2154 O  O   . ALA A 1 294 ? -27.900 6.341   -25.429 1.00 56.41  ?  294 ALA A O   1 
ATOM   2155 C  CB  . ALA A 1 294 ? -29.930 6.968   -27.942 1.00 52.66  ?  294 ALA A CB  1 
ATOM   2156 N  N   . MET A 1 295 ? -26.917 6.075   -27.473 1.00 56.14  ?  295 MET A N   1 
ATOM   2157 C  CA  . MET A 1 295 ? -25.892 5.081   -27.052 1.00 58.59  ?  295 MET A CA  1 
ATOM   2158 C  C   . MET A 1 295 ? -24.856 5.771   -26.160 1.00 54.94  ?  295 MET A C   1 
ATOM   2159 O  O   . MET A 1 295 ? -24.443 5.156   -25.169 1.00 55.71  ?  295 MET A O   1 
ATOM   2160 C  CB  . MET A 1 295 ? -25.187 4.435   -28.249 1.00 64.44  ?  295 MET A CB  1 
ATOM   2161 C  CG  . MET A 1 295 ? -25.916 3.218   -28.784 1.00 70.81  ?  295 MET A CG  1 
ATOM   2162 S  SD  . MET A 1 295 ? -24.871 2.183   -29.836 1.00 82.39  ?  295 MET A SD  1 
ATOM   2163 C  CE  . MET A 1 295 ? -24.850 3.146   -31.348 1.00 80.94  ?  295 MET A CE  1 
ATOM   2164 N  N   . PHE A 1 296 ? -24.459 7.000   -26.492 1.00 50.96  ?  296 PHE A N   1 
ATOM   2165 C  CA  . PHE A 1 296 ? -23.577 7.825   -25.629 1.00 51.73  ?  296 PHE A CA  1 
ATOM   2166 C  C   . PHE A 1 296 ? -24.245 8.004   -24.260 1.00 51.08  ?  296 PHE A C   1 
ATOM   2167 O  O   . PHE A 1 296 ? -23.564 7.861   -23.227 1.00 54.26  ?  296 PHE A O   1 
ATOM   2168 C  CB  . PHE A 1 296 ? -23.257 9.184   -26.254 1.00 50.72  ?  296 PHE A CB  1 
ATOM   2169 C  CG  . PHE A 1 296 ? -22.447 10.055  -25.330 1.00 49.49  ?  296 PHE A CG  1 
ATOM   2170 C  CD1 . PHE A 1 296 ? -21.094 9.820   -25.148 1.00 48.28  ?  296 PHE A CD1 1 
ATOM   2171 C  CD2 . PHE A 1 296 ? -23.049 11.058  -24.589 1.00 50.56  ?  296 PHE A CD2 1 
ATOM   2172 C  CE1 . PHE A 1 296 ? -20.355 10.599  -24.273 1.00 49.51  ?  296 PHE A CE1 1 
ATOM   2173 C  CE2 . PHE A 1 296 ? -22.309 11.833  -23.709 1.00 49.84  ?  296 PHE A CE2 1 
ATOM   2174 C  CZ  . PHE A 1 296 ? -20.964 11.600  -23.552 1.00 49.66  ?  296 PHE A CZ  1 
ATOM   2175 N  N   . GLY A 1 297 ? -25.545 8.299   -24.258 1.00 50.04  ?  297 GLY A N   1 
ATOM   2176 C  CA  . GLY A 1 297 ? -26.354 8.447   -23.034 1.00 50.75  ?  297 GLY A CA  1 
ATOM   2177 C  C   . GLY A 1 297 ? -26.286 7.210   -22.157 1.00 50.83  ?  297 GLY A C   1 
ATOM   2178 O  O   . GLY A 1 297 ? -26.113 7.365   -20.937 1.00 49.50  ?  297 GLY A O   1 
ATOM   2179 N  N   . GLU A 1 298 ? -26.420 6.023   -22.755 1.00 54.18  ?  298 GLU A N   1 
ATOM   2180 C  CA  . GLU A 1 298 ? -26.396 4.728   -22.023 1.00 59.68  ?  298 GLU A CA  1 
ATOM   2181 C  C   . GLU A 1 298 ? -25.038 4.565   -21.333 1.00 57.74  ?  298 GLU A C   1 
ATOM   2182 O  O   . GLU A 1 298 ? -25.016 4.279   -20.121 1.00 57.26  ?  298 GLU A O   1 
ATOM   2183 C  CB  . GLU A 1 298 ? -26.649 3.547   -22.962 1.00 66.49  ?  298 GLU A CB  1 
ATOM   2184 C  CG  . GLU A 1 298 ? -28.107 3.357   -23.324 1.00 73.15  ?  298 GLU A CG  1 
ATOM   2185 C  CD  . GLU A 1 298 ? -28.459 1.941   -23.743 1.00 80.44  ?  298 GLU A CD  1 
ATOM   2186 O  OE1 . GLU A 1 298 ? -28.300 1.023   -22.910 1.00 84.13  ?  298 GLU A OE1 1 
ATOM   2187 O  OE2 . GLU A 1 298 ? -28.888 1.758   -24.900 1.00 88.03  ?  298 GLU A OE2 1 
ATOM   2188 N  N   . PHE A 1 299 ? -23.951 4.740   -22.086 1.00 53.88  ?  299 PHE A N   1 
ATOM   2189 C  CA  . PHE A 1 299 ? -22.562 4.548   -21.594 1.00 52.39  ?  299 PHE A CA  1 
ATOM   2190 C  C   . PHE A 1 299 ? -22.240 5.606   -20.533 1.00 50.57  ?  299 PHE A C   1 
ATOM   2191 O  O   . PHE A 1 299 ? -21.618 5.239   -19.521 1.00 51.44  ?  299 PHE A O   1 
ATOM   2192 C  CB  . PHE A 1 299 ? -21.577 4.495   -22.764 1.00 51.87  ?  299 PHE A CB  1 
ATOM   2193 C  CG  . PHE A 1 299 ? -21.559 3.150   -23.446 1.00 51.75  ?  299 PHE A CG  1 
ATOM   2194 C  CD1 . PHE A 1 299 ? -20.874 2.084   -22.887 1.00 50.57  ?  299 PHE A CD1 1 
ATOM   2195 C  CD2 . PHE A 1 299 ? -22.264 2.935   -24.619 1.00 52.35  ?  299 PHE A CD2 1 
ATOM   2196 C  CE1 . PHE A 1 299 ? -20.871 0.842   -23.502 1.00 50.73  ?  299 PHE A CE1 1 
ATOM   2197 C  CE2 . PHE A 1 299 ? -22.260 1.692   -25.233 1.00 52.12  ?  299 PHE A CE2 1 
ATOM   2198 C  CZ  . PHE A 1 299 ? -21.566 0.647   -24.671 1.00 51.03  ?  299 PHE A CZ  1 
ATOM   2199 N  N   . PHE A 1 300 ? -22.666 6.857   -20.733 1.00 47.79  ?  300 PHE A N   1 
ATOM   2200 C  CA  . PHE A 1 300 ? -22.503 7.945   -19.732 1.00 47.89  ?  300 PHE A CA  1 
ATOM   2201 C  C   . PHE A 1 300 ? -23.198 7.534   -18.425 1.00 47.46  ?  300 PHE A C   1 
ATOM   2202 O  O   . PHE A 1 300 ? -22.606 7.682   -17.337 1.00 47.16  ?  300 PHE A O   1 
ATOM   2203 C  CB  . PHE A 1 300 ? -23.047 9.279   -20.251 1.00 46.94  ?  300 PHE A CB  1 
ATOM   2204 C  CG  . PHE A 1 300 ? -23.026 10.379  -19.221 1.00 45.27  ?  300 PHE A CG  1 
ATOM   2205 C  CD1 . PHE A 1 300 ? -21.900 11.167  -19.046 1.00 46.10  ?  300 PHE A CD1 1 
ATOM   2206 C  CD2 . PHE A 1 300 ? -24.121 10.605  -18.403 1.00 45.70  ?  300 PHE A CD2 1 
ATOM   2207 C  CE1 . PHE A 1 300 ? -21.878 12.170  -18.089 1.00 46.98  ?  300 PHE A CE1 1 
ATOM   2208 C  CE2 . PHE A 1 300 ? -24.098 11.607  -17.446 1.00 46.58  ?  300 PHE A CE2 1 
ATOM   2209 C  CZ  . PHE A 1 300 ? -22.976 12.385  -17.289 1.00 47.00  ?  300 PHE A CZ  1 
ATOM   2210 N  N   . SER A 1 301 ? -24.423 7.020   -18.537 1.00 46.48  ?  301 SER A N   1 
ATOM   2211 C  CA  . SER A 1 301 ? -25.238 6.560   -17.380 1.00 45.94  ?  301 SER A CA  1 
ATOM   2212 C  C   . SER A 1 301 ? -24.507 5.425   -16.656 1.00 45.92  ?  301 SER A C   1 
ATOM   2213 O  O   . SER A 1 301 ? -24.392 5.501   -15.422 1.00 47.51  ?  301 SER A O   1 
ATOM   2214 C  CB  . SER A 1 301 ? -26.612 6.140   -17.817 1.00 45.06  ?  301 SER A CB  1 
ATOM   2215 O  OG  . SER A 1 301 ? -27.379 7.267   -18.196 1.00 44.25  ?  301 SER A OG  1 
ATOM   2216 N  N   . MET A 1 302 ? -24.013 4.433   -17.405 1.00 46.30  ?  302 MET A N   1 
ATOM   2217 C  CA  . MET A 1 302 ? -23.318 3.237   -16.855 1.00 47.05  ?  302 MET A CA  1 
ATOM   2218 C  C   . MET A 1 302 ? -22.024 3.663   -16.142 1.00 48.32  ?  302 MET A C   1 
ATOM   2219 O  O   . MET A 1 302 ? -21.791 3.172   -15.025 1.00 50.86  ?  302 MET A O   1 
ATOM   2220 C  CB  . MET A 1 302 ? -23.015 2.215   -17.956 1.00 48.03  ?  302 MET A CB  1 
ATOM   2221 C  CG  . MET A 1 302 ? -24.238 1.411   -18.378 1.00 50.93  ?  302 MET A CG  1 
ATOM   2222 S  SD  . MET A 1 302 ? -23.877 0.081   -19.569 1.00 55.60  ?  302 MET A SD  1 
ATOM   2223 C  CE  . MET A 1 302 ? -23.506 1.035   -21.037 1.00 56.22  ?  302 MET A CE  1 
ATOM   2224 N  N   . PHE A 1 303 ? -21.230 4.564   -16.729 1.00 48.94  ?  303 PHE A N   1 
ATOM   2225 C  CA  . PHE A 1 303 ? -19.914 4.991   -16.178 1.00 49.84  ?  303 PHE A CA  1 
ATOM   2226 C  C   . PHE A 1 303 ? -20.116 5.868   -14.937 1.00 49.14  ?  303 PHE A C   1 
ATOM   2227 O  O   . PHE A 1 303 ? -19.367 5.682   -13.964 1.00 50.24  ?  303 PHE A O   1 
ATOM   2228 C  CB  . PHE A 1 303 ? -19.056 5.702   -17.229 1.00 51.17  ?  303 PHE A CB  1 
ATOM   2229 C  CG  . PHE A 1 303 ? -18.673 4.853   -18.416 1.00 54.01  ?  303 PHE A CG  1 
ATOM   2230 C  CD1 . PHE A 1 303 ? -18.557 3.473   -18.312 1.00 56.48  ?  303 PHE A CD1 1 
ATOM   2231 C  CD2 . PHE A 1 303 ? -18.418 5.441   -19.643 1.00 56.41  ?  303 PHE A CD2 1 
ATOM   2232 C  CE1 . PHE A 1 303 ? -18.213 2.703   -19.412 1.00 57.93  ?  303 PHE A CE1 1 
ATOM   2233 C  CE2 . PHE A 1 303 ? -18.078 4.669   -20.743 1.00 57.32  ?  303 PHE A CE2 1 
ATOM   2234 C  CZ  . PHE A 1 303 ? -17.970 3.302   -20.624 1.00 58.12  ?  303 PHE A CZ  1 
ATOM   2235 N  N   . LEU A 1 304 ? -21.075 6.795   -14.967 1.00 48.89  ?  304 LEU A N   1 
ATOM   2236 C  CA  . LEU A 1 304 ? -21.427 7.625   -13.781 1.00 49.43  ?  304 LEU A CA  1 
ATOM   2237 C  C   . LEU A 1 304 ? -21.855 6.700   -12.635 1.00 48.29  ?  304 LEU A C   1 
ATOM   2238 O  O   . LEU A 1 304 ? -21.469 6.972   -11.489 1.00 49.55  ?  304 LEU A O   1 
ATOM   2239 C  CB  . LEU A 1 304 ? -22.544 8.612   -14.130 1.00 50.66  ?  304 LEU A CB  1 
ATOM   2240 C  CG  . LEU A 1 304 ? -23.106 9.402   -12.949 1.00 51.59  ?  304 LEU A CG  1 
ATOM   2241 C  CD1 . LEU A 1 304 ? -22.023 10.246  -12.296 1.00 52.57  ?  304 LEU A CD1 1 
ATOM   2242 C  CD2 . LEU A 1 304 ? -24.273 10.273  -13.380 1.00 52.06  ?  304 LEU A CD2 1 
ATOM   2243 N  N   . GLN A 1 305 ? -22.623 5.652   -12.934 1.00 46.92  ?  305 GLN A N   1 
ATOM   2244 C  CA  . GLN A 1 305 ? -23.106 4.676   -11.921 1.00 49.31  ?  305 GLN A CA  1 
ATOM   2245 C  C   . GLN A 1 305 ? -21.905 4.052   -11.201 1.00 49.31  ?  305 GLN A C   1 
ATOM   2246 O  O   . GLN A 1 305 ? -21.897 4.067   -9.958  1.00 49.42  ?  305 GLN A O   1 
ATOM   2247 C  CB  . GLN A 1 305 ? -23.974 3.599   -12.571 1.00 49.83  ?  305 GLN A CB  1 
ATOM   2248 C  CG  . GLN A 1 305 ? -24.560 2.612   -11.575 1.00 49.99  ?  305 GLN A CG  1 
ATOM   2249 C  CD  . GLN A 1 305 ? -25.575 1.715   -12.234 1.00 50.21  ?  305 GLN A CD  1 
ATOM   2250 O  OE1 . GLN A 1 305 ? -26.615 2.173   -12.696 1.00 54.10  ?  305 GLN A OE1 1 
ATOM   2251 N  NE2 . GLN A 1 305 ? -25.279 0.426   -12.284 1.00 49.99  ?  305 GLN A NE2 1 
ATOM   2252 N  N   . VAL A 1 306 ? -20.933 3.535   -11.959 1.00 50.16  ?  306 VAL A N   1 
ATOM   2253 C  CA  . VAL A 1 306 ? -19.706 2.868   -11.426 1.00 50.27  ?  306 VAL A CA  1 
ATOM   2254 C  C   . VAL A 1 306 ? -18.889 3.884   -10.618 1.00 50.75  ?  306 VAL A C   1 
ATOM   2255 O  O   . VAL A 1 306 ? -18.395 3.511   -9.538  1.00 52.91  ?  306 VAL A O   1 
ATOM   2256 C  CB  . VAL A 1 306 ? -18.868 2.238   -12.556 1.00 51.38  ?  306 VAL A CB  1 
ATOM   2257 C  CG1 . VAL A 1 306 ? -17.495 1.794   -12.070 1.00 53.50  ?  306 VAL A CG1 1 
ATOM   2258 C  CG2 . VAL A 1 306 ? -19.598 1.075   -13.213 1.00 50.54  ?  306 VAL A CG2 1 
ATOM   2259 N  N   . LEU A 1 307 ? -18.741 5.111   -11.125 1.00 51.25  ?  307 LEU A N   1 
ATOM   2260 C  CA  . LEU A 1 307 ? -17.967 6.191   -10.454 1.00 51.85  ?  307 LEU A CA  1 
ATOM   2261 C  C   . LEU A 1 307 ? -18.654 6.594   -9.145  1.00 53.86  ?  307 LEU A C   1 
ATOM   2262 O  O   . LEU A 1 307 ? -17.932 6.827   -8.161  1.00 59.83  ?  307 LEU A O   1 
ATOM   2263 C  CB  . LEU A 1 307 ? -17.824 7.387   -11.397 1.00 50.77  ?  307 LEU A CB  1 
ATOM   2264 C  CG  . LEU A 1 307 ? -16.892 7.169   -12.587 1.00 51.46  ?  307 LEU A CG  1 
ATOM   2265 C  CD1 . LEU A 1 307 ? -16.995 8.328   -13.564 1.00 51.87  ?  307 LEU A CD1 1 
ATOM   2266 C  CD2 . LEU A 1 307 ? -15.451 6.974   -12.136 1.00 50.66  ?  307 LEU A CD2 1 
ATOM   2267 N  N   . LYS A 1 308 ? -19.987 6.685   -9.142  1.00 56.56  ?  308 LYS A N   1 
ATOM   2268 C  CA  . LYS A 1 308 ? -20.809 6.926   -7.921  1.00 58.94  ?  308 LYS A CA  1 
ATOM   2269 C  C   . LYS A 1 308 ? -20.523 5.834   -6.883  1.00 56.07  ?  308 LYS A C   1 
ATOM   2270 O  O   . LYS A 1 308 ? -20.386 6.171   -5.698  1.00 54.72  ?  308 LYS A O   1 
ATOM   2271 C  CB  . LYS A 1 308 ? -22.304 6.918   -8.252  1.00 63.52  ?  308 LYS A CB  1 
ATOM   2272 C  CG  . LYS A 1 308 ? -22.855 8.208   -8.839  1.00 68.45  ?  308 LYS A CG  1 
ATOM   2273 C  CD  . LYS A 1 308 ? -23.751 8.961   -7.885  1.00 73.39  ?  308 LYS A CD  1 
ATOM   2274 C  CE  . LYS A 1 308 ? -25.060 8.252   -7.607  1.00 76.08  ?  308 LYS A CE  1 
ATOM   2275 N  NZ  . LYS A 1 308 ? -25.650 8.697   -6.323  1.00 80.25  ?  308 LYS A NZ  1 
ATOM   2276 N  N   . GLN A 1 309 ? -20.459 4.576   -7.325  1.00 55.95  ?  309 GLN A N   1 
ATOM   2277 C  CA  . GLN A 1 309 ? -20.202 3.389   -6.465  1.00 58.00  ?  309 GLN A CA  1 
ATOM   2278 C  C   . GLN A 1 309 ? -18.782 3.487   -5.891  1.00 57.83  ?  309 GLN A C   1 
ATOM   2279 O  O   . GLN A 1 309 ? -18.635 3.309   -4.669  1.00 55.59  ?  309 GLN A O   1 
ATOM   2280 C  CB  . GLN A 1 309 ? -20.408 2.102   -7.268  1.00 61.21  ?  309 GLN A CB  1 
ATOM   2281 C  CG  . GLN A 1 309 ? -20.380 0.830   -6.431  1.00 65.17  ?  309 GLN A CG  1 
ATOM   2282 C  CD  . GLN A 1 309 ? -20.278 -0.424  -7.269  1.00 69.00  ?  309 GLN A CD  1 
ATOM   2283 O  OE1 . GLN A 1 309 ? -19.714 -0.426  -8.362  1.00 66.77  ?  309 GLN A OE1 1 
ATOM   2284 N  NE2 . GLN A 1 309 ? -20.817 -1.518  -6.754  1.00 74.88  ?  309 GLN A NE2 1 
ATOM   2285 N  N   . LYS A 1 310 ? -17.784 3.767   -6.737  1.00 58.21  ?  310 LYS A N   1 
ATOM   2286 C  CA  . LYS A 1 310 ? -16.358 3.885   -6.323  1.00 60.33  ?  310 LYS A CA  1 
ATOM   2287 C  C   . LYS A 1 310 ? -16.213 4.991   -5.274  1.00 60.23  ?  310 LYS A C   1 
ATOM   2288 O  O   . LYS A 1 310 ? -15.483 4.765   -4.293  1.00 62.20  ?  310 LYS A O   1 
ATOM   2289 C  CB  . LYS A 1 310 ? -15.440 4.162   -7.515  1.00 63.24  ?  310 LYS A CB  1 
ATOM   2290 C  CG  . LYS A 1 310 ? -15.116 2.942   -8.364  1.00 69.35  ?  310 LYS A CG  1 
ATOM   2291 C  CD  . LYS A 1 310 ? -13.976 3.152   -9.345  1.00 74.42  ?  310 LYS A CD  1 
ATOM   2292 C  CE  . LYS A 1 310 ? -14.072 2.263   -10.569 1.00 76.75  ?  310 LYS A CE  1 
ATOM   2293 N  NZ  . LYS A 1 310 ? -12.749 2.051   -11.202 1.00 80.32  ?  310 LYS A NZ  1 
ATOM   2294 N  N   . ARG A 1 311 ? -16.866 6.141   -5.471  1.00 60.39  ?  311 ARG A N   1 
ATOM   2295 C  CA  . ARG A 1 311 ? -16.729 7.305   -4.550  1.00 64.75  ?  311 ARG A CA  1 
ATOM   2296 C  C   . ARG A 1 311 ? -17.313 6.944   -3.180  1.00 63.62  ?  311 ARG A C   1 
ATOM   2297 O  O   . ARG A 1 311 ? -16.685 7.283   -2.164  1.00 65.40  ?  311 ARG A O   1 
ATOM   2298 C  CB  . ARG A 1 311 ? -17.411 8.556   -5.107  1.00 69.12  ?  311 ARG A CB  1 
ATOM   2299 C  CG  . ARG A 1 311 ? -17.197 9.794   -4.246  1.00 73.97  ?  311 ARG A CG  1 
ATOM   2300 C  CD  . ARG A 1 311 ? -17.834 11.033  -4.837  1.00 81.97  ?  311 ARG A CD  1 
ATOM   2301 N  NE  . ARG A 1 311 ? -19.279 10.883  -4.945  1.00 88.74  ?  311 ARG A NE  1 
ATOM   2302 C  CZ  . ARG A 1 311 ? -20.080 11.674  -5.654  1.00 94.68  ?  311 ARG A CZ  1 
ATOM   2303 N  NH1 . ARG A 1 311 ? -21.380 11.431  -5.679  1.00 96.65  ?  311 ARG A NH1 1 
ATOM   2304 N  NH2 . ARG A 1 311 ? -19.588 12.697  -6.337  1.00 96.93  ?  311 ARG A NH2 1 
ATOM   2305 N  N   . ARG A 1 312 ? -18.472 6.287   -3.166  1.00 63.63  ?  312 ARG A N   1 
ATOM   2306 C  CA  . ARG A 1 312 ? -19.143 5.839   -1.912  1.00 65.85  ?  312 ARG A CA  1 
ATOM   2307 C  C   . ARG A 1 312 ? -18.179 4.936   -1.130  1.00 61.82  ?  312 ARG A C   1 
ATOM   2308 O  O   . ARG A 1 312 ? -17.966 5.204   0.058   1.00 59.95  ?  312 ARG A O   1 
ATOM   2309 C  CB  . ARG A 1 312 ? -20.454 5.122   -2.239  1.00 72.10  ?  312 ARG A CB  1 
ATOM   2310 C  CG  . ARG A 1 312 ? -21.475 5.133   -1.112  1.00 79.52  ?  312 ARG A CG  1 
ATOM   2311 C  CD  . ARG A 1 312 ? -22.818 4.617   -1.595  1.00 88.81  ?  312 ARG A CD  1 
ATOM   2312 N  NE  . ARG A 1 312 ? -23.889 4.889   -0.645  1.00 96.85  ?  312 ARG A NE  1 
ATOM   2313 C  CZ  . ARG A 1 312 ? -24.112 4.205   0.476   1.00 103.33 ?  312 ARG A CZ  1 
ATOM   2314 N  NH1 . ARG A 1 312 ? -23.328 3.192   0.816   1.00 105.88 ?  312 ARG A NH1 1 
ATOM   2315 N  NH2 . ARG A 1 312 ? -25.122 4.542   1.259   1.00 104.75 ?  312 ARG A NH2 1 
ATOM   2316 N  N   . LEU A 1 313 ? -17.616 3.921   -1.790  1.00 59.16  ?  313 LEU A N   1 
ATOM   2317 C  CA  . LEU A 1 313 ? -16.595 2.995   -1.223  1.00 60.54  ?  313 LEU A CA  1 
ATOM   2318 C  C   . LEU A 1 313 ? -15.430 3.787   -0.624  1.00 59.26  ?  313 LEU A C   1 
ATOM   2319 O  O   . LEU A 1 313 ? -15.068 3.509   0.533   1.00 60.57  ?  313 LEU A O   1 
ATOM   2320 C  CB  . LEU A 1 313 ? -16.078 2.062   -2.322  1.00 63.63  ?  313 LEU A CB  1 
ATOM   2321 C  CG  . LEU A 1 313 ? -16.669 0.656   -2.322  1.00 67.26  ?  313 LEU A CG  1 
ATOM   2322 C  CD1 . LEU A 1 313 ? -18.186 0.696   -2.418  1.00 69.32  ?  313 LEU A CD1 1 
ATOM   2323 C  CD2 . LEU A 1 313 ? -16.080 -0.162  -3.456  1.00 70.87  ?  313 LEU A CD2 1 
ATOM   2324 N  N   . ASP A 1 314 ? -14.845 4.701   -1.401  1.00 58.86  ?  314 ASP A N   1 
ATOM   2325 C  CA  . ASP A 1 314 ? -13.658 5.496   -0.987  1.00 59.85  ?  314 ASP A CA  1 
ATOM   2326 C  C   . ASP A 1 314 ? -14.017 6.305   0.265   1.00 57.43  ?  314 ASP A C   1 
ATOM   2327 O  O   . ASP A 1 314 ? -13.228 6.273   1.231   1.00 59.91  ?  314 ASP A O   1 
ATOM   2328 C  CB  . ASP A 1 314 ? -13.145 6.372   -2.134  1.00 60.16  ?  314 ASP A CB  1 
ATOM   2329 C  CG  . ASP A 1 314 ? -12.526 5.582   -3.276  1.00 63.06  ?  314 ASP A CG  1 
ATOM   2330 O  OD1 . ASP A 1 314 ? -12.264 4.378   -3.084  1.00 64.09  ?  314 ASP A OD1 1 
ATOM   2331 O  OD2 . ASP A 1 314 ? -12.324 6.174   -4.358  1.00 69.40  -1 314 ASP A OD2 1 
ATOM   2332 N  N   . THR A 1 315 ? -15.162 6.993   0.240   1.00 54.70  ?  315 THR A N   1 
ATOM   2333 C  CA  . THR A 1 315 ? -15.697 7.800   1.374   1.00 54.70  ?  315 THR A CA  1 
ATOM   2334 C  C   . THR A 1 315 ? -15.798 6.934   2.637   1.00 52.85  ?  315 THR A C   1 
ATOM   2335 O  O   . THR A 1 315 ? -15.307 7.376   3.688   1.00 55.21  ?  315 THR A O   1 
ATOM   2336 C  CB  . THR A 1 315 ? -17.053 8.425   1.022   1.00 55.80  ?  315 THR A CB  1 
ATOM   2337 O  OG1 . THR A 1 315 ? -16.890 9.103   -0.222  1.00 59.77  ?  315 THR A OG1 1 
ATOM   2338 C  CG2 . THR A 1 315 ? -17.556 9.403   2.060   1.00 56.97  ?  315 THR A CG2 1 
ATOM   2339 N  N   . ILE A 1 316 ? -16.405 5.751   2.530   1.00 52.29  ?  316 ILE A N   1 
ATOM   2340 C  CA  . ILE A 1 316 ? -16.680 4.839   3.680   1.00 53.51  ?  316 ILE A CA  1 
ATOM   2341 C  C   . ILE A 1 316 ? -15.354 4.233   4.157   1.00 54.29  ?  316 ILE A C   1 
ATOM   2342 O  O   . ILE A 1 316 ? -15.169 4.138   5.381   1.00 55.69  ?  316 ILE A O   1 
ATOM   2343 C  CB  . ILE A 1 316 ? -17.710 3.752   3.307   1.00 55.96  ?  316 ILE A CB  1 
ATOM   2344 C  CG1 . ILE A 1 316 ? -19.005 4.345   2.734   1.00 57.14  ?  316 ILE A CG1 1 
ATOM   2345 C  CG2 . ILE A 1 316 ? -17.977 2.838   4.496   1.00 56.43  ?  316 ILE A CG2 1 
ATOM   2346 C  CD1 . ILE A 1 316 ? -20.108 4.572   3.737   1.00 58.44  ?  316 ILE A CD1 1 
ATOM   2347 N  N   . ASN A 1 317 ? -14.474 3.832   3.234   1.00 55.82  ?  317 ASN A N   1 
ATOM   2348 C  CA  . ASN A 1 317 ? -13.112 3.322   3.553   1.00 59.03  ?  317 ASN A CA  1 
ATOM   2349 C  C   . ASN A 1 317 ? -12.345 4.373   4.356   1.00 58.75  ?  317 ASN A C   1 
ATOM   2350 O  O   . ASN A 1 317 ? -11.742 4.004   5.379   1.00 59.69  ?  317 ASN A O   1 
ATOM   2351 C  CB  . ASN A 1 317 ? -12.293 2.979   2.309   1.00 64.03  ?  317 ASN A CB  1 
ATOM   2352 C  CG  . ASN A 1 317 ? -12.535 1.580   1.791   1.00 70.03  ?  317 ASN A CG  1 
ATOM   2353 O  OD1 . ASN A 1 317 ? -13.050 0.721   2.504   1.00 71.80  ?  317 ASN A OD1 1 
ATOM   2354 N  ND2 . ASN A 1 317 ? -12.155 1.348   0.546   1.00 73.98  ?  317 ASN A ND2 1 
ATOM   2355 N  N   . HIS A 1 318 ? -12.350 5.621   3.886   1.00 58.87  ?  318 HIS A N   1 
ATOM   2356 C  CA  . HIS A 1 318 ? -11.636 6.756   4.526   1.00 61.04  ?  318 HIS A CA  1 
ATOM   2357 C  C   . HIS A 1 318 ? -12.144 6.938   5.961   1.00 58.02  ?  318 HIS A C   1 
ATOM   2358 O  O   . HIS A 1 318 ? -11.308 7.168   6.861   1.00 59.67  ?  318 HIS A O   1 
ATOM   2359 C  CB  . HIS A 1 318 ? -11.774 8.042   3.703   1.00 67.26  ?  318 HIS A CB  1 
ATOM   2360 C  CG  . HIS A 1 318 ? -11.131 9.210   4.372   1.00 78.07  ?  318 HIS A CG  1 
ATOM   2361 N  ND1 . HIS A 1 318 ? -11.867 10.230  4.949   1.00 84.67  ?  318 HIS A ND1 1 
ATOM   2362 C  CD2 . HIS A 1 318 ? -9.831  9.493   4.611   1.00 82.12  ?  318 HIS A CD2 1 
ATOM   2363 C  CE1 . HIS A 1 318 ? -11.043 11.107  5.490   1.00 90.18  ?  318 HIS A CE1 1 
ATOM   2364 N  NE2 . HIS A 1 318 ? -9.786  10.675  5.298   1.00 87.16  ?  318 HIS A NE2 1 
ATOM   2365 N  N   . ALA A 1 319 ? -13.460 6.842   6.165   1.00 53.28  ?  319 ALA A N   1 
ATOM   2366 C  CA  . ALA A 1 319 ? -14.105 6.971   7.492   1.00 51.98  ?  319 ALA A CA  1 
ATOM   2367 C  C   . ALA A 1 319 ? -13.608 5.846   8.407   1.00 52.67  ?  319 ALA A C   1 
ATOM   2368 O  O   . ALA A 1 319 ? -13.196 6.146   9.538   1.00 55.01  ?  319 ALA A O   1 
ATOM   2369 C  CB  . ALA A 1 319 ? -15.603 6.962   7.350   1.00 51.87  ?  319 ALA A CB  1 
ATOM   2370 N  N   . HIS A 1 320 ? -13.625 4.603   7.919   1.00 52.60  ?  320 HIS A N   1 
ATOM   2371 C  CA  . HIS A 1 320 ? -13.153 3.397   8.653   1.00 54.66  ?  320 HIS A CA  1 
ATOM   2372 C  C   . HIS A 1 320 ? -11.695 3.586   9.090   1.00 55.83  ?  320 HIS A C   1 
ATOM   2373 O  O   . HIS A 1 320 ? -11.383 3.236   10.241  1.00 60.67  ?  320 HIS A O   1 
ATOM   2374 C  CB  . HIS A 1 320 ? -13.348 2.131   7.807   1.00 56.18  ?  320 HIS A CB  1 
ATOM   2375 C  CG  . HIS A 1 320 ? -14.733 1.586   7.881   1.00 58.18  ?  320 HIS A CG  1 
ATOM   2376 N  ND1 . HIS A 1 320 ? -15.824 2.276   7.402   1.00 62.79  ?  320 HIS A ND1 1 
ATOM   2377 C  CD2 . HIS A 1 320 ? -15.214 0.437   8.396   1.00 61.04  ?  320 HIS A CD2 1 
ATOM   2378 C  CE1 . HIS A 1 320 ? -16.917 1.570   7.605   1.00 62.55  ?  320 HIS A CE1 1 
ATOM   2379 N  NE2 . HIS A 1 320 ? -16.569 0.434   8.210   1.00 62.05  ?  320 HIS A NE2 1 
ATOM   2380 N  N   . ALA A 1 321 ? -10.847 4.126   8.210   1.00 55.88  ?  321 ALA A N   1 
ATOM   2381 C  CA  . ALA A 1 321 ? -9.405  4.373   8.461   1.00 55.66  ?  321 ALA A CA  1 
ATOM   2382 C  C   . ALA A 1 321 ? -9.238  5.413   9.576   1.00 56.00  ?  321 ALA A C   1 
ATOM   2383 O  O   . ALA A 1 321 ? -8.460  5.161   10.515  1.00 59.27  ?  321 ALA A O   1 
ATOM   2384 C  CB  . ALA A 1 321 ? -8.724  4.823   7.192   1.00 55.59  ?  321 ALA A CB  1 
ATOM   2385 N  N   . ALA A 1 322 ? -9.934  6.546   9.460   1.00 54.47  ?  322 ALA A N   1 
ATOM   2386 C  CA  . ALA A 1 322 ? -9.957  7.636   10.464  1.00 53.82  ?  322 ALA A CA  1 
ATOM   2387 C  C   . ALA A 1 322 ? -10.348 7.068   11.835  1.00 55.10  ?  322 ALA A C   1 
ATOM   2388 O  O   . ALA A 1 322 ? -9.634  7.348   12.821  1.00 56.46  ?  322 ALA A O   1 
ATOM   2389 C  CB  . ALA A 1 322 ? -10.910 8.718   10.020  1.00 51.74  ?  322 ALA A CB  1 
ATOM   2390 N  N   . LEU A 1 323 ? -11.432 6.287   11.887  1.00 53.97  ?  323 LEU A N   1 
ATOM   2391 C  CA  . LEU A 1 323 ? -11.962 5.687   13.141  1.00 54.47  ?  323 LEU A CA  1 
ATOM   2392 C  C   . LEU A 1 323 ? -10.939 4.706   13.722  1.00 55.13  ?  323 LEU A C   1 
ATOM   2393 O  O   . LEU A 1 323 ? -10.733 4.755   14.939  1.00 57.95  ?  323 LEU A O   1 
ATOM   2394 C  CB  . LEU A 1 323 ? -13.308 5.008   12.868  1.00 53.97  ?  323 LEU A CB  1 
ATOM   2395 C  CG  . LEU A 1 323 ? -14.489 5.957   12.677  1.00 53.46  ?  323 LEU A CG  1 
ATOM   2396 C  CD1 . LEU A 1 323 ? -15.727 5.195   12.227  1.00 53.92  ?  323 LEU A CD1 1 
ATOM   2397 C  CD2 . LEU A 1 323 ? -14.775 6.741   13.950  1.00 53.20  ?  323 LEU A CD2 1 
ATOM   2398 N  N   . ASP A 1 324 ? -10.320 3.857   12.896  1.00 57.63  ?  324 ASP A N   1 
ATOM   2399 C  CA  . ASP A 1 324 ? -9.243  2.931   13.345  1.00 60.60  ?  324 ASP A CA  1 
ATOM   2400 C  C   . ASP A 1 324 ? -8.139  3.766   14.000  1.00 58.81  ?  324 ASP A C   1 
ATOM   2401 O  O   . ASP A 1 324 ? -7.776  3.456   15.148  1.00 61.92  ?  324 ASP A O   1 
ATOM   2402 C  CB  . ASP A 1 324 ? -8.688  2.069   12.204  1.00 65.97  ?  324 ASP A CB  1 
ATOM   2403 C  CG  . ASP A 1 324 ? -9.530  0.850   11.854  1.00 72.69  ?  324 ASP A CG  1 
ATOM   2404 O  OD1 . ASP A 1 324 ? -10.474 0.538   12.614  1.00 78.12  -1 324 ASP A OD1 1 
ATOM   2405 O  OD2 . ASP A 1 324 ? -9.237  0.217   10.818  1.00 79.53  ?  324 ASP A OD2 1 
ATOM   2406 N  N   . ARG A 1 325 ? -7.644  4.797   13.306  1.00 56.68  ?  325 ARG A N   1 
ATOM   2407 C  CA  . ARG A 1 325 ? -6.603  5.719   13.844  1.00 57.10  ?  325 ARG A CA  1 
ATOM   2408 C  C   . ARG A 1 325 ? -7.041  6.203   15.233  1.00 57.45  ?  325 ARG A C   1 
ATOM   2409 O  O   . ARG A 1 325 ? -6.242  6.081   16.181  1.00 58.70  ?  325 ARG A O   1 
ATOM   2410 C  CB  . ARG A 1 325 ? -6.353  6.892   12.890  1.00 55.01  ?  325 ARG A CB  1 
ATOM   2411 N  N   . PHE A 1 326 ? -8.274  6.704   15.351  1.00 57.25  ?  326 PHE A N   1 
ATOM   2412 C  CA  . PHE A 1 326 ? -8.826  7.274   16.609  1.00 57.67  ?  326 PHE A CA  1 
ATOM   2413 C  C   . PHE A 1 326 ? -8.869  6.204   17.706  1.00 59.83  ?  326 PHE A C   1 
ATOM   2414 O  O   . PHE A 1 326 ? -8.476  6.518   18.843  1.00 63.32  ?  326 PHE A O   1 
ATOM   2415 C  CB  . PHE A 1 326 ? -10.220 7.864   16.395  1.00 56.06  ?  326 PHE A CB  1 
ATOM   2416 C  CG  . PHE A 1 326 ? -10.839 8.396   17.660  1.00 55.15  ?  326 PHE A CG  1 
ATOM   2417 C  CD1 . PHE A 1 326 ? -10.446 9.618   18.177  1.00 56.87  ?  326 PHE A CD1 1 
ATOM   2418 C  CD2 . PHE A 1 326 ? -11.789 7.659   18.351  1.00 57.40  ?  326 PHE A CD2 1 
ATOM   2419 C  CE1 . PHE A 1 326 ? -11.005 10.102  19.350  1.00 60.45  ?  326 PHE A CE1 1 
ATOM   2420 C  CE2 . PHE A 1 326 ? -12.348 8.143   19.523  1.00 58.11  ?  326 PHE A CE2 1 
ATOM   2421 C  CZ  . PHE A 1 326 ? -11.954 9.364   20.022  1.00 59.82  ?  326 PHE A CZ  1 
ATOM   2422 N  N   . LEU A 1 327 ? -9.342  4.997   17.379  1.00 60.52  ?  327 LEU A N   1 
ATOM   2423 C  CA  . LEU A 1 327 ? -9.439  3.852   18.329  1.00 61.77  ?  327 LEU A CA  1 
ATOM   2424 C  C   . LEU A 1 327 ? -8.039  3.477   18.830  1.00 63.13  ?  327 LEU A C   1 
ATOM   2425 O  O   . LEU A 1 327 ? -7.924  3.115   20.020  1.00 64.60  ?  327 LEU A O   1 
ATOM   2426 C  CB  . LEU A 1 327 ? -10.115 2.658   17.644  1.00 61.42  ?  327 LEU A CB  1 
ATOM   2427 C  CG  . LEU A 1 327 ? -11.581 2.849   17.251  1.00 63.81  ?  327 LEU A CG  1 
ATOM   2428 C  CD1 . LEU A 1 327 ? -12.177 1.551   16.728  1.00 64.11  ?  327 LEU A CD1 1 
ATOM   2429 C  CD2 . LEU A 1 327 ? -12.409 3.372   18.413  1.00 64.06  ?  327 LEU A CD2 1 
ATOM   2430 N  N   . ARG A 1 328 ? -7.024  3.564   17.959  1.00 63.46  ?  328 ARG A N   1 
ATOM   2431 C  CA  . ARG A 1 328 ? -5.605  3.249   18.294  1.00 65.73  ?  328 ARG A CA  1 
ATOM   2432 C  C   . ARG A 1 328 ? -5.071  4.276   19.306  1.00 68.50  ?  328 ARG A C   1 
ATOM   2433 O  O   . ARG A 1 328 ? -4.304  3.865   20.199  1.00 73.07  ?  328 ARG A O   1 
ATOM   2434 C  CB  . ARG A 1 328 ? -4.746  3.196   17.025  1.00 63.12  ?  328 ARG A CB  1 
ATOM   2435 N  N   . LEU A 1 329 ? -5.465  5.550   19.176  1.00 69.34  ?  329 LEU A N   1 
ATOM   2436 C  CA  . LEU A 1 329 ? -5.109  6.651   20.120  1.00 70.14  ?  329 LEU A CA  1 
ATOM   2437 C  C   . LEU A 1 329 ? -5.823  6.446   21.460  1.00 72.53  ?  329 LEU A C   1 
ATOM   2438 O  O   . LEU A 1 329 ? -5.175  6.628   22.503  1.00 75.72  ?  329 LEU A O   1 
ATOM   2439 C  CB  . LEU A 1 329 ? -5.508  8.007   19.526  1.00 71.76  ?  329 LEU A CB  1 
ATOM   2440 C  CG  . LEU A 1 329 ? -4.564  8.593   18.479  1.00 73.50  ?  329 LEU A CG  1 
ATOM   2441 C  CD1 . LEU A 1 329 ? -5.194  9.810   17.820  1.00 75.08  ?  329 LEU A CD1 1 
ATOM   2442 C  CD2 . LEU A 1 329 ? -3.219  8.961   19.089  1.00 73.31  ?  329 LEU A CD2 1 
ATOM   2443 N  N   . ALA A 1 330 ? -7.115  6.111   21.419  1.00 75.71  ?  330 ALA A N   1 
ATOM   2444 C  CA  . ALA A 1 330 ? -8.013  5.986   22.594  1.00 76.99  ?  330 ALA A CA  1 
ATOM   2445 C  C   . ALA A 1 330 ? -7.466  4.949   23.583  1.00 81.44  ?  330 ALA A C   1 
ATOM   2446 O  O   . ALA A 1 330 ? -7.717  5.105   24.793  1.00 82.42  ?  330 ALA A O   1 
ATOM   2447 C  CB  . ALA A 1 330 ? -9.409  5.625   22.148  1.00 76.73  ?  330 ALA A CB  1 
ATOM   2448 N  N   . ALA A 1 331 ? -6.766  3.927   23.084  1.00 84.28  ?  331 ALA A N   1 
ATOM   2449 C  CA  . ALA A 1 331 ? -6.183  2.831   23.894  1.00 87.37  ?  331 ALA A CA  1 
ATOM   2450 C  C   . ALA A 1 331 ? -5.025  3.367   24.746  1.00 89.14  ?  331 ALA A C   1 
ATOM   2451 O  O   . ALA A 1 331 ? -4.865  2.889   25.881  1.00 95.20  ?  331 ALA A O   1 
ATOM   2452 C  CB  . ALA A 1 331 ? -5.732  1.707   22.994  1.00 88.45  ?  331 ALA A CB  1 
ATOM   2453 N  N   . HIS A 1 332 ? -4.263  4.330   24.218  1.00 92.60  ?  332 HIS A N   1 
ATOM   2454 C  CA  . HIS A 1 332 ? -2.991  4.833   24.808  1.00 96.49  ?  332 HIS A CA  1 
ATOM   2455 C  C   . HIS A 1 332 ? -3.264  5.965   25.804  1.00 92.79  ?  332 HIS A C   1 
ATOM   2456 O  O   . HIS A 1 332 ? -2.482  6.086   26.764  1.00 97.63  ?  332 HIS A O   1 
ATOM   2457 C  CB  . HIS A 1 332 ? -2.009  5.241   23.700  1.00 103.05 ?  332 HIS A CB  1 
ATOM   2458 C  CG  . HIS A 1 332 ? -1.388  4.070   23.015  1.00 110.05 ?  332 HIS A CG  1 
ATOM   2459 N  ND1 . HIS A 1 332 ? -2.057  3.341   22.051  1.00 113.04 ?  332 HIS A ND1 1 
ATOM   2460 C  CD2 . HIS A 1 332 ? -0.179  3.486   23.164  1.00 114.88 ?  332 HIS A CD2 1 
ATOM   2461 C  CE1 . HIS A 1 332 ? -1.282  2.364   21.626  1.00 116.96 ?  332 HIS A CE1 1 
ATOM   2462 N  NE2 . HIS A 1 332 ? -0.123  2.431   22.293  1.00 118.70 ?  332 HIS A NE2 1 
ATOM   2463 N  N   . ARG A 1 333 ? -4.307  6.771   25.581  1.00 89.70  ?  333 ARG A N   1 
ATOM   2464 C  CA  . ARG A 1 333 ? -4.782  7.779   26.573  1.00 90.11  ?  333 ARG A CA  1 
ATOM   2465 C  C   . ARG A 1 333 ? -5.628  7.083   27.650  1.00 90.13  ?  333 ARG A C   1 
ATOM   2466 O  O   . ARG A 1 333 ? -6.279  6.071   27.336  1.00 93.20  ?  333 ARG A O   1 
ATOM   2467 C  CB  . ARG A 1 333 ? -5.583  8.898   25.899  1.00 89.93  ?  333 ARG A CB  1 
ATOM   2468 C  CG  . ARG A 1 333 ? -4.735  9.946   25.190  1.00 89.91  ?  333 ARG A CG  1 
ATOM   2469 C  CD  . ARG A 1 333 ? -5.222  11.364  25.455  1.00 89.21  ?  333 ARG A CD  1 
ATOM   2470 N  NE  . ARG A 1 333 ? -4.901  12.293  24.376  1.00 89.07  ?  333 ARG A NE  1 
ATOM   2471 C  CZ  . ARG A 1 333 ? -5.148  13.602  24.393  1.00 86.45  ?  333 ARG A CZ  1 
ATOM   2472 N  NH1 . ARG A 1 333 ? -4.820  14.348  23.351  1.00 83.27  ?  333 ARG A NH1 1 
ATOM   2473 N  NH2 . ARG A 1 333 ? -5.720  14.166  25.445  1.00 85.95  ?  333 ARG A NH2 1 
ATOM   2474 N  N   . ALA A 1 334 ? -5.608  7.618   28.874  1.00 90.26  ?  334 ALA A N   1 
ATOM   2475 C  CA  . ALA A 1 334 ? -6.417  7.157   30.028  1.00 89.17  ?  334 ALA A CA  1 
ATOM   2476 C  C   . ALA A 1 334 ? -7.765  7.887   30.030  1.00 87.99  ?  334 ALA A C   1 
ATOM   2477 O  O   . ALA A 1 334 ? -8.814  7.217   30.132  1.00 87.46  ?  334 ALA A O   1 
ATOM   2478 C  CB  . ALA A 1 334 ? -5.659  7.400   31.311  1.00 90.16  ?  334 ALA A CB  1 
ATOM   2479 N  N   . ASN A 1 335 ? -7.723  9.217   29.911  1.00 83.57  ?  335 ASN A N   1 
ATOM   2480 C  CA  . ASN A 1 335 ? -8.910  10.114  29.947  1.00 79.88  ?  335 ASN A CA  1 
ATOM   2481 C  C   . ASN A 1 335 ? -9.464  10.279  28.524  1.00 76.85  ?  335 ASN A C   1 
ATOM   2482 O  O   . ASN A 1 335 ? -8.834  10.993  27.723  1.00 78.24  ?  335 ASN A O   1 
ATOM   2483 C  CB  . ASN A 1 335 ? -8.551  11.454  30.594  1.00 78.17  ?  335 ASN A CB  1 
ATOM   2484 C  CG  . ASN A 1 335 ? -9.765  12.268  30.982  1.00 79.54  ?  335 ASN A CG  1 
ATOM   2485 O  OD1 . ASN A 1 335 ? -10.799 12.211  30.322  1.00 80.43  ?  335 ASN A OD1 1 
ATOM   2486 N  ND2 . ASN A 1 335 ? -9.651  13.032  32.055  1.00 85.45  ?  335 ASN A ND2 1 
ATOM   2487 N  N   . LEU A 1 336 ? -10.609 9.651   28.238  1.00 74.09  ?  336 LEU A N   1 
ATOM   2488 C  CA  . LEU A 1 336 ? -11.268 9.654   26.901  1.00 74.03  ?  336 LEU A CA  1 
ATOM   2489 C  C   . LEU A 1 336 ? -11.886 11.029  26.621  1.00 73.10  ?  336 LEU A C   1 
ATOM   2490 O  O   . LEU A 1 336 ? -11.852 11.467  25.454  1.00 72.58  ?  336 LEU A O   1 
ATOM   2491 C  CB  . LEU A 1 336 ? -12.342 8.561   26.866  1.00 74.11  ?  336 LEU A CB  1 
ATOM   2492 C  CG  . LEU A 1 336 ? -13.043 8.363   25.523  1.00 74.54  ?  336 LEU A CG  1 
ATOM   2493 C  CD1 . LEU A 1 336 ? -12.073 7.848   24.469  1.00 74.16  ?  336 LEU A CD1 1 
ATOM   2494 C  CD2 . LEU A 1 336 ? -14.221 7.414   25.667  1.00 76.30  ?  336 LEU A CD2 1 
ATOM   2495 N  N   . GLU A 1 337 ? -12.459 11.660  27.647  1.00 72.76  ?  337 GLU A N   1 
ATOM   2496 C  CA  . GLU A 1 337 ? -13.092 13.003  27.560  1.00 74.65  ?  337 GLU A CA  1 
ATOM   2497 C  C   . GLU A 1 337 ? -12.032 14.037  27.155  1.00 72.50  ?  337 GLU A C   1 
ATOM   2498 O  O   . GLU A 1 337 ? -12.359 14.920  26.341  1.00 71.35  ?  337 GLU A O   1 
ATOM   2499 C  CB  . GLU A 1 337 ? -13.762 13.349  28.892  1.00 79.34  ?  337 GLU A CB  1 
ATOM   2500 C  CG  . GLU A 1 337 ? -14.321 14.758  28.951  1.00 83.03  ?  337 GLU A CG  1 
ATOM   2501 C  CD  . GLU A 1 337 ? -15.111 15.054  30.213  1.00 87.88  ?  337 GLU A CD  1 
ATOM   2502 O  OE1 . GLU A 1 337 ? -14.755 16.027  30.911  1.00 85.98  ?  337 GLU A OE1 1 
ATOM   2503 O  OE2 . GLU A 1 337 ? -16.081 14.310  30.492  1.00 90.49  -1 337 GLU A OE2 1 
ATOM   2504 N  N   . GLU A 1 338 ? -10.816 13.929  27.704  1.00 70.08  ?  338 GLU A N   1 
ATOM   2505 C  CA  . GLU A 1 338 ? -9.646  14.770  27.321  1.00 67.57  ?  338 GLU A CA  1 
ATOM   2506 C  C   . GLU A 1 338 ? -9.373  14.606  25.822  1.00 62.25  ?  338 GLU A C   1 
ATOM   2507 O  O   . GLU A 1 338 ? -9.280  15.635  25.128  1.00 62.60  ?  338 GLU A O   1 
ATOM   2508 C  CB  . GLU A 1 338 ? -8.389  14.380  28.102  1.00 72.87  ?  338 GLU A CB  1 
ATOM   2509 C  CG  . GLU A 1 338 ? -7.991  15.369  29.184  1.00 77.24  ?  338 GLU A CG  1 
ATOM   2510 C  CD  . GLU A 1 338 ? -6.602  15.131  29.759  1.00 81.76  ?  338 GLU A CD  1 
ATOM   2511 O  OE1 . GLU A 1 338 ? -6.298  15.721  30.815  1.00 86.57  ?  338 GLU A OE1 1 
ATOM   2512 O  OE2 . GLU A 1 338 ? -5.825  14.355  29.150  1.00 80.18  -1 338 GLU A OE2 1 
ATOM   2513 N  N   . LEU A 1 339 ? -9.250  13.357  25.359  1.00 57.73  ?  339 LEU A N   1 
ATOM   2514 C  CA  . LEU A 1 339 ? -8.960  13.004  23.940  1.00 56.19  ?  339 LEU A CA  1 
ATOM   2515 C  C   . LEU A 1 339 ? -10.048 13.578  23.026  1.00 55.34  ?  339 LEU A C   1 
ATOM   2516 O  O   . LEU A 1 339 ? -9.691  14.149  21.985  1.00 56.00  ?  339 LEU A O   1 
ATOM   2517 C  CB  . LEU A 1 339 ? -8.864  11.484  23.787  1.00 56.28  ?  339 LEU A CB  1 
ATOM   2518 C  CG  . LEU A 1 339 ? -8.651  10.976  22.361  1.00 57.07  ?  339 LEU A CG  1 
ATOM   2519 C  CD1 . LEU A 1 339 ? -7.373  11.541  21.759  1.00 57.07  ?  339 LEU A CD1 1 
ATOM   2520 C  CD2 . LEU A 1 339 ? -8.624  9.457   22.328  1.00 58.40  ?  339 LEU A CD2 1 
ATOM   2521 N  N   . LEU A 1 340 ? -11.320 13.433  23.405  1.00 55.37  ?  340 LEU A N   1 
ATOM   2522 C  CA  . LEU A 1 340 ? -12.475 13.952  22.622  1.00 55.34  ?  340 LEU A CA  1 
ATOM   2523 C  C   . LEU A 1 340 ? -12.383 15.478  22.520  1.00 53.27  ?  340 LEU A C   1 
ATOM   2524 O  O   . LEU A 1 340 ? -12.601 15.999  21.412  1.00 54.49  ?  340 LEU A O   1 
ATOM   2525 C  CB  . LEU A 1 340 ? -13.795 13.511  23.263  1.00 57.02  ?  340 LEU A CB  1 
ATOM   2526 C  CG  . LEU A 1 340 ? -14.184 12.052  23.026  1.00 59.14  ?  340 LEU A CG  1 
ATOM   2527 C  CD1 . LEU A 1 340 ? -15.394 11.671  23.864  1.00 60.27  ?  340 LEU A CD1 1 
ATOM   2528 C  CD2 . LEU A 1 340 ? -14.457 11.786  21.552  1.00 60.01  ?  340 LEU A CD2 1 
ATOM   2529 N  N   . VAL A 1 341 ? -12.056 16.167  23.615  1.00 52.29  ?  341 VAL A N   1 
ATOM   2530 C  CA  . VAL A 1 341 ? -11.961 17.659  23.640  1.00 53.03  ?  341 VAL A CA  1 
ATOM   2531 C  C   . VAL A 1 341 ? -10.861 18.113  22.667  1.00 52.89  ?  341 VAL A C   1 
ATOM   2532 O  O   . VAL A 1 341 ? -11.070 19.130  21.976  1.00 52.66  ?  341 VAL A O   1 
ATOM   2533 C  CB  . VAL A 1 341 ? -11.727 18.202  25.063  1.00 53.38  ?  341 VAL A CB  1 
ATOM   2534 C  CG1 . VAL A 1 341 ? -11.357 19.678  25.045  1.00 54.96  ?  341 VAL A CG1 1 
ATOM   2535 C  CG2 . VAL A 1 341 ? -12.938 17.977  25.957  1.00 52.97  ?  341 VAL A CG2 1 
ATOM   2536 N  N   . ASP A 1 342 ? -9.743  17.382  22.603  1.00 52.03  ?  342 ASP A N   1 
ATOM   2537 C  CA  . ASP A 1 342 ? -8.578  17.716  21.740  1.00 51.68  ?  342 ASP A CA  1 
ATOM   2538 C  C   . ASP A 1 342 ? -8.864  17.356  20.275  1.00 52.41  ?  342 ASP A C   1 
ATOM   2539 O  O   . ASP A 1 342 ? -8.342  18.068  19.398  1.00 53.48  ?  342 ASP A O   1 
ATOM   2540 C  CB  . ASP A 1 342 ? -7.311  17.000  22.217  1.00 51.68  ?  342 ASP A CB  1 
ATOM   2541 C  CG  . ASP A 1 342 ? -6.815  17.456  23.579  1.00 51.16  ?  342 ASP A CG  1 
ATOM   2542 O  OD1 . ASP A 1 342 ? -7.115  18.604  23.963  1.00 50.42  ?  342 ASP A OD1 1 
ATOM   2543 O  OD2 . ASP A 1 342 ? -6.136  16.654  24.252  1.00 50.54  -1 342 ASP A OD2 1 
ATOM   2544 N  N   . SER A 1 343 ? -9.658  16.303  20.032  1.00 53.31  ?  343 SER A N   1 
ATOM   2545 C  CA  . SER A 1 343 ? -9.755  15.571  18.732  1.00 53.24  ?  343 SER A CA  1 
ATOM   2546 C  C   . SER A 1 343 ? -11.015 15.927  17.933  1.00 52.27  ?  343 SER A C   1 
ATOM   2547 O  O   . SER A 1 343 ? -10.990 15.727  16.708  1.00 53.56  ?  343 SER A O   1 
ATOM   2548 C  CB  . SER A 1 343 ? -9.713  14.077  18.950  1.00 55.10  ?  343 SER A CB  1 
ATOM   2549 O  OG  . SER A 1 343 ? -8.562  13.696  19.688  1.00 58.64  ?  343 SER A OG  1 
ATOM   2550 N  N   . PHE A 1 344 ? -12.083 16.393  18.585  1.00 50.73  ?  344 PHE A N   1 
ATOM   2551 C  CA  . PHE A 1 344 ? -13.459 16.394  18.014  1.00 49.91  ?  344 PHE A CA  1 
ATOM   2552 C  C   . PHE A 1 344 ? -13.490 17.095  16.647  1.00 50.98  ?  344 PHE A C   1 
ATOM   2553 O  O   . PHE A 1 344 ? -14.284 16.666  15.791  1.00 53.26  ?  344 PHE A O   1 
ATOM   2554 C  CB  . PHE A 1 344 ? -14.473 17.004  18.986  1.00 48.82  ?  344 PHE A CB  1 
ATOM   2555 C  CG  . PHE A 1 344 ? -14.442 18.504  19.108  1.00 46.54  ?  344 PHE A CG  1 
ATOM   2556 C  CD1 . PHE A 1 344 ? -15.189 19.300  18.255  1.00 46.74  ?  344 PHE A CD1 1 
ATOM   2557 C  CD2 . PHE A 1 344 ? -13.686 19.116  20.092  1.00 47.04  ?  344 PHE A CD2 1 
ATOM   2558 C  CE1 . PHE A 1 344 ? -15.166 20.681  18.375  1.00 47.88  ?  344 PHE A CE1 1 
ATOM   2559 C  CE2 . PHE A 1 344 ? -13.666 20.497  20.213  1.00 47.27  ?  344 PHE A CE2 1 
ATOM   2560 C  CZ  . PHE A 1 344 ? -14.406 21.277  19.355  1.00 47.20  ?  344 PHE A CZ  1 
ATOM   2561 N  N   . GLN A 1 345 ? -12.679 18.137  16.442  1.00 50.30  ?  345 GLN A N   1 
ATOM   2562 C  CA  . GLN A 1 345 ? -12.659 18.911  15.167  1.00 49.12  ?  345 GLN A CA  1 
ATOM   2563 C  C   . GLN A 1 345 ? -12.250 17.993  14.004  1.00 48.14  ?  345 GLN A C   1 
ATOM   2564 O  O   . GLN A 1 345 ? -12.700 18.244  12.870  1.00 45.78  ?  345 GLN A O   1 
ATOM   2565 C  CB  . GLN A 1 345 ? -11.742 20.133  15.269  1.00 48.88  ?  345 GLN A CB  1 
ATOM   2566 C  CG  . GLN A 1 345 ? -10.254 19.812  15.268  1.00 48.41  ?  345 GLN A CG  1 
ATOM   2567 C  CD  . GLN A 1 345 ? -9.712  19.486  16.639  1.00 48.77  ?  345 GLN A CD  1 
ATOM   2568 O  OE1 . GLN A 1 345 ? -10.280 19.858  17.663  1.00 48.91  ?  345 GLN A OE1 1 
ATOM   2569 N  NE2 . GLN A 1 345 ? -8.583  18.796  16.668  1.00 49.29  ?  345 GLN A NE2 1 
ATOM   2570 N  N   . ASP A 1 346 ? -11.444 16.963  14.280  1.00 48.48  ?  346 ASP A N   1 
ATOM   2571 C  CA  . ASP A 1 346 ? -10.889 16.033  13.260  1.00 50.10  ?  346 ASP A CA  1 
ATOM   2572 C  C   . ASP A 1 346 ? -12.002 15.165  12.668  1.00 51.88  ?  346 ASP A C   1 
ATOM   2573 O  O   . ASP A 1 346 ? -11.809 14.670  11.543  1.00 54.92  ?  346 ASP A O   1 
ATOM   2574 C  CB  . ASP A 1 346 ? -9.787  15.148  13.845  1.00 50.65  ?  346 ASP A CB  1 
ATOM   2575 C  CG  . ASP A 1 346 ? -8.572  15.913  14.344  1.00 51.27  ?  346 ASP A CG  1 
ATOM   2576 O  OD1 . ASP A 1 346 ? -8.418  17.098  13.968  1.00 50.14  ?  346 ASP A OD1 1 
ATOM   2577 O  OD2 . ASP A 1 346 ? -7.788  15.313  15.103  1.00 52.80  -1 346 ASP A OD2 1 
ATOM   2578 N  N   . PHE A 1 347 ? -13.117 14.988  13.387  1.00 53.63  ?  347 PHE A N   1 
ATOM   2579 C  CA  . PHE A 1 347 ? -14.290 14.194  12.930  1.00 54.82  ?  347 PHE A CA  1 
ATOM   2580 C  C   . PHE A 1 347 ? -15.019 14.918  11.792  1.00 54.59  ?  347 PHE A C   1 
ATOM   2581 O  O   . PHE A 1 347 ? -15.830 14.270  11.112  1.00 56.35  ?  347 PHE A O   1 
ATOM   2582 C  CB  . PHE A 1 347 ? -15.233 13.875  14.094  1.00 55.97  ?  347 PHE A CB  1 
ATOM   2583 C  CG  . PHE A 1 347 ? -14.699 12.827  15.037  1.00 58.42  ?  347 PHE A CG  1 
ATOM   2584 C  CD1 . PHE A 1 347 ? -14.479 11.529  14.603  1.00 60.85  ?  347 PHE A CD1 1 
ATOM   2585 C  CD2 . PHE A 1 347 ? -14.405 13.136  16.354  1.00 60.07  ?  347 PHE A CD2 1 
ATOM   2586 C  CE1 . PHE A 1 347 ? -13.978 10.565  15.466  1.00 61.88  ?  347 PHE A CE1 1 
ATOM   2587 C  CE2 . PHE A 1 347 ? -13.904 12.171  17.215  1.00 61.88  ?  347 PHE A CE2 1 
ATOM   2588 C  CZ  . PHE A 1 347 ? -13.690 10.888  16.770  1.00 60.72  ?  347 PHE A CZ  1 
ATOM   2589 N  N   . ALA A 1 348 ? -14.733 16.207  11.581  1.00 56.65  ?  348 ALA A N   1 
ATOM   2590 C  CA  . ALA A 1 348 ? -15.262 17.016  10.455  1.00 58.18  ?  348 ALA A CA  1 
ATOM   2591 C  C   . ALA A 1 348 ? -14.769 16.449  9.115   1.00 59.37  ?  348 ALA A C   1 
ATOM   2592 O  O   . ALA A 1 348 ? -15.398 16.762  8.086   1.00 60.60  ?  348 ALA A O   1 
ATOM   2593 C  CB  . ALA A 1 348 ? -14.873 18.466  10.617  1.00 56.38  ?  348 ALA A CB  1 
ATOM   2594 N  N   . ARG A 1 349 ? -13.697 15.645  9.131   1.00 61.45  ?  349 ARG A N   1 
ATOM   2595 C  CA  . ARG A 1 349 ? -13.142 14.975  7.916   1.00 65.03  ?  349 ARG A CA  1 
ATOM   2596 C  C   . ARG A 1 349 ? -14.084 13.857  7.443   1.00 61.25  ?  349 ARG A C   1 
ATOM   2597 O  O   . ARG A 1 349 ? -14.120 13.615  6.226   1.00 60.65  ?  349 ARG A O   1 
ATOM   2598 C  CB  . ARG A 1 349 ? -11.754 14.391  8.194   1.00 72.91  ?  349 ARG A CB  1 
ATOM   2599 C  CG  . ARG A 1 349 ? -10.661 15.428  8.411   1.00 80.78  ?  349 ARG A CG  1 
ATOM   2600 C  CD  . ARG A 1 349 ? -9.379  14.789  8.922   1.00 89.05  ?  349 ARG A CD  1 
ATOM   2601 N  NE  . ARG A 1 349 ? -8.467  15.746  9.541   1.00 95.52  ?  349 ARG A NE  1 
ATOM   2602 C  CZ  . ARG A 1 349 ? -7.470  15.435  10.374  1.00 100.89 ?  349 ARG A CZ  1 
ATOM   2603 N  NH1 . ARG A 1 349 ? -7.232  14.176  10.711  1.00 99.02  ?  349 ARG A NH1 1 
ATOM   2604 N  NH2 . ARG A 1 349 ? -6.711  16.395  10.875  1.00 103.69 ?  349 ARG A NH2 1 
ATOM   2605 N  N   . LEU A 1 350 ? -14.809 13.210  8.365   1.00 59.00  ?  350 LEU A N   1 
ATOM   2606 C  CA  . LEU A 1 350 ? -15.669 12.021  8.093   1.00 57.34  ?  350 LEU A CA  1 
ATOM   2607 C  C   . LEU A 1 350 ? -16.893 12.426  7.271   1.00 56.14  ?  350 LEU A C   1 
ATOM   2608 O  O   . LEU A 1 350 ? -17.217 11.709  6.307   1.00 59.00  ?  350 LEU A O   1 
ATOM   2609 C  CB  . LEU A 1 350 ? -16.134 11.388  9.408   1.00 58.09  ?  350 LEU A CB  1 
ATOM   2610 C  CG  . LEU A 1 350 ? -15.041 10.953  10.382  1.00 61.16  ?  350 LEU A CG  1 
ATOM   2611 C  CD1 . LEU A 1 350 ? -15.599 9.975   11.405  1.00 63.98  ?  350 LEU A CD1 1 
ATOM   2612 C  CD2 . LEU A 1 350 ? -13.857 10.336  9.657   1.00 61.22  ?  350 LEU A CD2 1 
ATOM   2613 N  N   . ILE A 1 351 ? -17.564 13.506  7.674   1.00 56.52  ?  351 ILE A N   1 
ATOM   2614 C  CA  . ILE A 1 351 ? -18.871 13.944  7.101   1.00 57.04  ?  351 ILE A CA  1 
ATOM   2615 C  C   . ILE A 1 351 ? -18.764 15.410  6.693   1.00 55.23  ?  351 ILE A C   1 
ATOM   2616 O  O   . ILE A 1 351 ? -18.395 16.255  7.504   1.00 56.67  ?  351 ILE A O   1 
ATOM   2617 C  CB  . ILE A 1 351 ? -20.012 13.705  8.111   1.00 60.40  ?  351 ILE A CB  1 
ATOM   2618 C  CG1 . ILE A 1 351 ? -20.064 12.243  8.562   1.00 61.73  ?  351 ILE A CG1 1 
ATOM   2619 C  CG2 . ILE A 1 351 ? -21.348 14.160  7.540   1.00 62.50  ?  351 ILE A CG2 1 
ATOM   2620 C  CD1 . ILE A 1 351 ? -20.990 11.993  9.725   1.00 64.26  ?  351 ILE A CD1 1 
ATOM   2621 N  N   . PRO A 1 352 ? -19.086 15.758  5.425   1.00 53.92  ?  352 PRO A N   1 
ATOM   2622 C  CA  . PRO A 1 352 ? -19.119 17.154  4.997   1.00 52.57  ?  352 PRO A CA  1 
ATOM   2623 C  C   . PRO A 1 352 ? -20.029 17.992  5.907   1.00 53.55  ?  352 PRO A C   1 
ATOM   2624 O  O   . PRO A 1 352 ? -21.230 17.746  5.949   1.00 52.88  ?  352 PRO A O   1 
ATOM   2625 C  CB  . PRO A 1 352 ? -19.682 17.104  3.569   1.00 52.74  ?  352 PRO A CB  1 
ATOM   2626 C  CG  . PRO A 1 352 ? -19.412 15.691  3.096   1.00 53.22  ?  352 PRO A CG  1 
ATOM   2627 C  CD  . PRO A 1 352 ? -19.441 14.830  4.340   1.00 54.06  ?  352 PRO A CD  1 
ATOM   2628 N  N   . CYS A 1 353 ? -19.433 18.940  6.632   1.00 51.80  ?  353 CYS A N   1 
ATOM   2629 C  CA  . CYS A 1 353 ? -20.163 19.881  7.523   1.00 53.45  ?  353 CYS A CA  1 
ATOM   2630 C  C   . CYS A 1 353 ? -19.461 21.240  7.512   1.00 52.80  ?  353 CYS A C   1 
ATOM   2631 O  O   . CYS A 1 353 ? -18.270 21.281  7.173   1.00 55.96  ?  353 CYS A O   1 
ATOM   2632 C  CB  . CYS A 1 353 ? -20.230 19.329  8.941   1.00 52.68  ?  353 CYS A CB  1 
ATOM   2633 S  SG  . CYS A 1 353 ? -18.595 18.965  9.623   1.00 53.30  ?  353 CYS A SG  1 
ATOM   2634 N  N   . ASP A 1 354 ? -20.182 22.304  7.864   1.00 52.86  ?  354 ASP A N   1 
ATOM   2635 C  CA  . ASP A 1 354 ? -19.640 23.686  7.949   1.00 52.66  ?  354 ASP A CA  1 
ATOM   2636 C  C   . ASP A 1 354 ? -19.164 23.951  9.384   1.00 51.91  ?  354 ASP A C   1 
ATOM   2637 O  O   . ASP A 1 354 ? -18.479 24.967  9.605   1.00 51.07  ?  354 ASP A O   1 
ATOM   2638 C  CB  . ASP A 1 354 ? -20.682 24.692  7.460   1.00 53.48  ?  354 ASP A CB  1 
ATOM   2639 C  CG  . ASP A 1 354 ? -21.118 24.432  6.029   1.00 56.15  ?  354 ASP A CG  1 
ATOM   2640 O  OD1 . ASP A 1 354 ? -20.241 24.436  5.138   1.00 60.23  ?  354 ASP A OD1 1 
ATOM   2641 O  OD2 . ASP A 1 354 ? -22.327 24.211  5.815   1.00 58.78  -1 354 ASP A OD2 1 
ATOM   2642 N  N   . GLY A 1 355 ? -19.511 23.060  10.317  1.00 51.17  ?  355 GLY A N   1 
ATOM   2643 C  CA  . GLY A 1 355 ? -19.124 23.160  11.737  1.00 50.95  ?  355 GLY A CA  1 
ATOM   2644 C  C   . GLY A 1 355 ? -19.386 21.863  12.476  1.00 49.90  ?  355 GLY A C   1 
ATOM   2645 O  O   . GLY A 1 355 ? -20.318 21.142  12.089  1.00 49.96  ?  355 GLY A O   1 
ATOM   2646 N  N   . VAL A 1 356 ? -18.582 21.575  13.497  1.00 50.50  ?  356 VAL A N   1 
ATOM   2647 C  CA  . VAL A 1 356 ? -18.710 20.365  14.359  1.00 54.14  ?  356 VAL A CA  1 
ATOM   2648 C  C   . VAL A 1 356 ? -18.559 20.812  15.818  1.00 56.10  ?  356 VAL A C   1 
ATOM   2649 O  O   . VAL A 1 356 ? -17.824 21.784  16.067  1.00 60.09  ?  356 VAL A O   1 
ATOM   2650 C  CB  . VAL A 1 356 ? -17.681 19.284  13.966  1.00 55.52  ?  356 VAL A CB  1 
ATOM   2651 C  CG1 . VAL A 1 356 ? -16.248 19.743  14.191  1.00 56.82  ?  356 VAL A CG1 1 
ATOM   2652 C  CG2 . VAL A 1 356 ? -17.932 17.970  14.686  1.00 56.26  ?  356 VAL A CG2 1 
ATOM   2653 N  N   . GLY A 1 357 ? -19.239 20.133  16.741  1.00 56.85  ?  357 GLY A N   1 
ATOM   2654 C  CA  . GLY A 1 357 ? -19.216 20.468  18.177  1.00 55.82  ?  357 GLY A CA  1 
ATOM   2655 C  C   . GLY A 1 357 ? -19.256 19.232  19.053  1.00 55.48  ?  357 GLY A C   1 
ATOM   2656 O  O   . GLY A 1 357 ? -19.800 18.201  18.613  1.00 52.47  ?  357 GLY A O   1 
ATOM   2657 N  N   . LEU A 1 358 ? -18.687 19.339  20.254  1.00 57.99  ?  358 LEU A N   1 
ATOM   2658 C  CA  . LEU A 1 358 ? -18.676 18.267  21.284  1.00 58.91  ?  358 LEU A CA  1 
ATOM   2659 C  C   . LEU A 1 358 ? -19.498 18.740  22.488  1.00 61.18  ?  358 LEU A C   1 
ATOM   2660 O  O   . LEU A 1 358 ? -19.171 19.808  23.047  1.00 62.07  ?  358 LEU A O   1 
ATOM   2661 C  CB  . LEU A 1 358 ? -17.226 17.967  21.672  1.00 57.55  ?  358 LEU A CB  1 
ATOM   2662 C  CG  . LEU A 1 358 ? -17.022 16.809  22.646  1.00 59.30  ?  358 LEU A CG  1 
ATOM   2663 C  CD1 . LEU A 1 358 ? -17.488 15.495  22.041  1.00 60.93  ?  358 LEU A CD1 1 
ATOM   2664 C  CD2 . LEU A 1 358 ? -15.562 16.707  23.056  1.00 60.24  ?  358 LEU A CD2 1 
ATOM   2665 N  N   . TRP A 1 359 ? -20.559 18.002  22.821  1.00 61.56  ?  359 TRP A N   1 
ATOM   2666 C  CA  . TRP A 1 359 ? -21.358 18.179  24.062  1.00 62.03  ?  359 TRP A CA  1 
ATOM   2667 C  C   . TRP A 1 359 ? -21.064 16.990  24.975  1.00 62.24  ?  359 TRP A C   1 
ATOM   2668 O  O   . TRP A 1 359 ? -21.650 15.917  24.757  1.00 62.51  ?  359 TRP A O   1 
ATOM   2669 C  CB  . TRP A 1 359 ? -22.852 18.318  23.748  1.00 63.56  ?  359 TRP A CB  1 
ATOM   2670 C  CG  . TRP A 1 359 ? -23.721 18.502  24.955  1.00 65.04  ?  359 TRP A CG  1 
ATOM   2671 C  CD1 . TRP A 1 359 ? -24.475 17.550  25.579  1.00 65.75  ?  359 TRP A CD1 1 
ATOM   2672 C  CD2 . TRP A 1 359 ? -23.936 19.722  25.686  1.00 66.59  ?  359 TRP A CD2 1 
ATOM   2673 N  NE1 . TRP A 1 359 ? -25.140 18.091  26.646  1.00 66.33  ?  359 TRP A NE1 1 
ATOM   2674 C  CE2 . TRP A 1 359 ? -24.832 19.422  26.735  1.00 67.14  ?  359 TRP A CE2 1 
ATOM   2675 C  CE3 . TRP A 1 359 ? -23.465 21.034  25.557  1.00 68.41  ?  359 TRP A CE3 1 
ATOM   2676 C  CZ2 . TRP A 1 359 ? -25.260 20.389  27.645  1.00 68.05  ?  359 TRP A CZ2 1 
ATOM   2677 C  CZ3 . TRP A 1 359 ? -23.887 21.988  26.458  1.00 69.06  ?  359 TRP A CZ3 1 
ATOM   2678 C  CH2 . TRP A 1 359 ? -24.770 21.666  27.489  1.00 68.59  ?  359 TRP A CH2 1 
ATOM   2679 N  N   . VAL A 1 360 ? -20.149 17.171  25.927  1.00 66.16  ?  360 VAL A N   1 
ATOM   2680 C  CA  . VAL A 1 360 ? -19.684 16.098  26.853  1.00 70.08  ?  360 VAL A CA  1 
ATOM   2681 C  C   . VAL A 1 360 ? -19.715 16.660  28.279  1.00 71.94  ?  360 VAL A C   1 
ATOM   2682 O  O   . VAL A 1 360 ? -19.190 17.773  28.483  1.00 70.31  ?  360 VAL A O   1 
ATOM   2683 C  CB  . VAL A 1 360 ? -18.295 15.565  26.445  1.00 71.71  ?  360 VAL A CB  1 
ATOM   2684 C  CG1 . VAL A 1 360 ? -17.247 16.665  26.369  1.00 72.98  ?  360 VAL A CG1 1 
ATOM   2685 C  CG2 . VAL A 1 360 ? -17.825 14.440  27.355  1.00 74.53  ?  360 VAL A CG2 1 
ATOM   2686 N  N   . GLY A 1 361 ? -20.349 15.929  29.205  1.00 74.92  ?  361 GLY A N   1 
ATOM   2687 C  CA  . GLY A 1 361 ? -20.520 16.314  30.622  1.00 75.51  ?  361 GLY A CA  1 
ATOM   2688 C  C   . GLY A 1 361 ? -21.072 17.724  30.782  1.00 75.17  ?  361 GLY A C   1 
ATOM   2689 O  O   . GLY A 1 361 ? -20.488 18.502  31.561  1.00 73.97  ?  361 GLY A O   1 
ATOM   2690 N  N   . ASN A 1 362 ? -22.148 18.048  30.058  1.00 77.06  ?  362 ASN A N   1 
ATOM   2691 C  CA  . ASN A 1 362 ? -22.849 19.364  30.105  1.00 82.36  ?  362 ASN A CA  1 
ATOM   2692 C  C   . ASN A 1 362 ? -21.859 20.510  29.849  1.00 80.47  ?  362 ASN A C   1 
ATOM   2693 O  O   . ASN A 1 362 ? -22.097 21.616  30.367  1.00 81.14  ?  362 ASN A O   1 
ATOM   2694 C  CB  . ASN A 1 362 ? -23.595 19.559  31.430  1.00 85.95  ?  362 ASN A CB  1 
ATOM   2695 C  CG  . ASN A 1 362 ? -24.664 18.510  31.659  1.00 90.03  ?  362 ASN A CG  1 
ATOM   2696 O  OD1 . ASN A 1 362 ? -25.625 18.415  30.895  1.00 91.56  ?  362 ASN A OD1 1 
ATOM   2697 N  ND2 . ASN A 1 362 ? -24.510 17.714  32.706  1.00 91.69  ?  362 ASN A ND2 1 
ATOM   2698 N  N   . ASN A 1 363 ? -20.800 20.254  29.071  1.00 80.41  ?  363 ASN A N   1 
ATOM   2699 C  CA  . ASN A 1 363 ? -19.838 21.276  28.573  1.00 76.87  ?  363 ASN A CA  1 
ATOM   2700 C  C   . ASN A 1 363 ? -19.905 21.308  27.046  1.00 70.60  ?  363 ASN A C   1 
ATOM   2701 O  O   . ASN A 1 363 ? -20.103 20.236  26.449  1.00 72.72  ?  363 ASN A O   1 
ATOM   2702 C  CB  . ASN A 1 363 ? -18.401 20.995  29.017  1.00 81.94  ?  363 ASN A CB  1 
ATOM   2703 C  CG  . ASN A 1 363 ? -18.082 21.562  30.383  1.00 86.00  ?  363 ASN A CG  1 
ATOM   2704 O  OD1 . ASN A 1 363 ? -18.241 22.759  30.613  1.00 87.38  ?  363 ASN A OD1 1 
ATOM   2705 N  ND2 . ASN A 1 363 ? -17.623 20.713  31.289  1.00 89.49  ?  363 ASN A ND2 1 
ATOM   2706 N  N   . TRP A 1 364 ? -19.725 22.490  26.455  1.00 65.44  ?  364 TRP A N   1 
ATOM   2707 C  CA  . TRP A 1 364 ? -19.778 22.719  24.986  1.00 63.46  ?  364 TRP A CA  1 
ATOM   2708 C  C   . TRP A 1 364 ? -18.413 23.173  24.458  1.00 63.58  ?  364 TRP A C   1 
ATOM   2709 O  O   . TRP A 1 364 ? -17.835 24.125  25.025  1.00 63.09  ?  364 TRP A O   1 
ATOM   2710 C  CB  . TRP A 1 364 ? -20.856 23.746  24.635  1.00 62.13  ?  364 TRP A CB  1 
ATOM   2711 C  CG  . TRP A 1 364 ? -20.804 24.195  23.208  1.00 60.03  ?  364 TRP A CG  1 
ATOM   2712 C  CD1 . TRP A 1 364 ? -20.432 25.420  22.739  1.00 58.41  ?  364 TRP A CD1 1 
ATOM   2713 C  CD2 . TRP A 1 364 ? -21.122 23.403  22.051  1.00 59.85  ?  364 TRP A CD2 1 
ATOM   2714 N  NE1 . TRP A 1 364 ? -20.513 25.453  21.374  1.00 57.57  ?  364 TRP A NE1 1 
ATOM   2715 C  CE2 . TRP A 1 364 ? -20.934 24.230  20.924  1.00 58.88  ?  364 TRP A CE2 1 
ATOM   2716 C  CE3 . TRP A 1 364 ? -21.559 22.087  21.862  1.00 61.52  ?  364 TRP A CE3 1 
ATOM   2717 C  CZ2 . TRP A 1 364 ? -21.169 23.778  19.628  1.00 60.85  ?  364 TRP A CZ2 1 
ATOM   2718 C  CZ3 . TRP A 1 364 ? -21.791 21.641  20.580  1.00 62.74  ?  364 TRP A CZ3 1 
ATOM   2719 C  CH2 . TRP A 1 364 ? -21.601 22.480  19.482  1.00 62.69  ?  364 TRP A CH2 1 
ATOM   2720 N  N   . HIS A 1 365 ? -17.947 22.517  23.392  1.00 62.91  ?  365 HIS A N   1 
ATOM   2721 C  CA  . HIS A 1 365 ? -16.763 22.914  22.585  1.00 61.37  ?  365 HIS A CA  1 
ATOM   2722 C  C   . HIS A 1 365 ? -17.175 22.973  21.112  1.00 59.36  ?  365 HIS A C   1 
ATOM   2723 O  O   . HIS A 1 365 ? -17.718 21.966  20.617  1.00 59.15  ?  365 HIS A O   1 
ATOM   2724 C  CB  . HIS A 1 365 ? -15.602 21.950  22.832  1.00 62.67  ?  365 HIS A CB  1 
ATOM   2725 C  CG  . HIS A 1 365 ? -15.257 21.794  24.275  1.00 65.12  ?  365 HIS A CG  1 
ATOM   2726 N  ND1 . HIS A 1 365 ? -14.339 22.613  24.907  1.00 64.89  ?  365 HIS A ND1 1 
ATOM   2727 C  CD2 . HIS A 1 365 ? -15.703 20.924  25.208  1.00 65.77  ?  365 HIS A CD2 1 
ATOM   2728 C  CE1 . HIS A 1 365 ? -14.230 22.247  26.168  1.00 67.83  ?  365 HIS A CE1 1 
ATOM   2729 N  NE2 . HIS A 1 365 ? -15.057 21.212  26.379  1.00 66.78  ?  365 HIS A NE2 1 
ATOM   2730 N  N   . GLY A 1 366 ? -16.946 24.119  20.464  1.00 57.17  ?  366 GLY A N   1 
ATOM   2731 C  CA  . GLY A 1 366 ? -17.333 24.382  19.064  1.00 56.90  ?  366 GLY A CA  1 
ATOM   2732 C  C   . GLY A 1 366 ? -16.136 24.435  18.128  1.00 56.30  ?  366 GLY A C   1 
ATOM   2733 O  O   . GLY A 1 366 ? -15.003 24.620  18.603  1.00 55.33  ?  366 GLY A O   1 
ATOM   2734 N  N   . HIS A 1 367 ? -16.394 24.275  16.831  1.00 59.02  ?  367 HIS A N   1 
ATOM   2735 C  CA  . HIS A 1 367 ? -15.408 24.439  15.729  1.00 60.60  ?  367 HIS A CA  1 
ATOM   2736 C  C   . HIS A 1 367 ? -16.166 24.724  14.430  1.00 59.53  ?  367 HIS A C   1 
ATOM   2737 O  O   . HIS A 1 367 ? -17.052 23.920  14.081  1.00 59.85  ?  367 HIS A O   1 
ATOM   2738 C  CB  . HIS A 1 367 ? -14.503 23.205  15.614  1.00 62.04  ?  367 HIS A CB  1 
ATOM   2739 C  CG  . HIS A 1 367 ? -13.463 23.333  14.551  1.00 65.94  ?  367 HIS A CG  1 
ATOM   2740 N  ND1 . HIS A 1 367 ? -12.324 24.100  14.720  1.00 66.58  ?  367 HIS A ND1 1 
ATOM   2741 C  CD2 . HIS A 1 367 ? -13.385 22.805  13.308  1.00 66.58  ?  367 HIS A CD2 1 
ATOM   2742 C  CE1 . HIS A 1 367 ? -11.589 24.033  13.629  1.00 66.32  ?  367 HIS A CE1 1 
ATOM   2743 N  NE2 . HIS A 1 367 ? -12.216 23.243  12.749  1.00 66.50  ?  367 HIS A NE2 1 
ATOM   2744 N  N   . GLY A 1 368 ? -15.832 25.829  13.759  1.00 58.98  ?  368 GLY A N   1 
ATOM   2745 C  CA  . GLY A 1 368 ? -16.477 26.258  12.503  1.00 59.31  ?  368 GLY A CA  1 
ATOM   2746 C  C   . GLY A 1 368 ? -17.819 26.914  12.763  1.00 59.53  ?  368 GLY A C   1 
ATOM   2747 O  O   . GLY A 1 368 ? -17.972 27.547  13.824  1.00 62.55  ?  368 GLY A O   1 
ATOM   2748 N  N   . ALA A 1 369 ? -18.759 26.771  11.826  1.00 59.35  ?  369 ALA A N   1 
ATOM   2749 C  CA  . ALA A 1 369 ? -20.116 27.361  11.897  1.00 61.42  ?  369 ALA A CA  1 
ATOM   2750 C  C   . ALA A 1 369 ? -21.018 26.484  12.775  1.00 64.42  ?  369 ALA A C   1 
ATOM   2751 O  O   . ALA A 1 369 ? -21.662 25.558  12.234  1.00 66.89  ?  369 ALA A O   1 
ATOM   2752 C  CB  . ALA A 1 369 ? -20.675 27.531  10.507  1.00 61.48  ?  369 ALA A CB  1 
ATOM   2753 N  N   . THR A 1 370 ? -21.045 26.770  14.082  1.00 64.86  ?  370 THR A N   1 
ATOM   2754 C  CA  . THR A 1 370 ? -21.967 26.149  15.078  1.00 65.34  ?  370 THR A CA  1 
ATOM   2755 C  C   . THR A 1 370 ? -22.949 27.208  15.569  1.00 66.08  ?  370 THR A C   1 
ATOM   2756 O  O   . THR A 1 370 ? -22.690 28.400  15.412  1.00 64.89  ?  370 THR A O   1 
ATOM   2757 C  CB  . THR A 1 370 ? -21.212 25.536  16.266  1.00 66.83  ?  370 THR A CB  1 
ATOM   2758 O  OG1 . THR A 1 370 ? -20.769 26.589  17.123  1.00 66.22  ?  370 THR A OG1 1 
ATOM   2759 C  CG2 . THR A 1 370 ? -20.028 24.691  15.849  1.00 68.20  ?  370 THR A CG2 1 
ATOM   2760 N  N   . PRO A 1 371 ? -24.096 26.820  16.177  1.00 65.68  ?  371 PRO A N   1 
ATOM   2761 C  CA  . PRO A 1 371 ? -24.992 27.788  16.808  1.00 65.76  ?  371 PRO A CA  1 
ATOM   2762 C  C   . PRO A 1 371 ? -24.285 28.511  17.953  1.00 66.83  ?  371 PRO A C   1 
ATOM   2763 O  O   . PRO A 1 371 ? -23.277 28.019  18.455  1.00 62.53  ?  371 PRO A O   1 
ATOM   2764 C  CB  . PRO A 1 371 ? -26.161 26.938  17.331  1.00 65.28  ?  371 PRO A CB  1 
ATOM   2765 C  CG  . PRO A 1 371 ? -26.080 25.649  16.539  1.00 64.40  ?  371 PRO A CG  1 
ATOM   2766 C  CD  . PRO A 1 371 ? -24.602 25.442  16.287  1.00 64.77  ?  371 PRO A CD  1 
ATOM   2767 N  N   . PRO A 1 372 ? -24.778 29.691  18.403  1.00 72.03  ?  372 PRO A N   1 
ATOM   2768 C  CA  . PRO A 1 372 ? -24.154 30.413  19.514  1.00 73.62  ?  372 PRO A CA  1 
ATOM   2769 C  C   . PRO A 1 372 ? -24.116 29.584  20.807  1.00 75.30  ?  372 PRO A C   1 
ATOM   2770 O  O   . PRO A 1 372 ? -24.955 28.718  20.964  1.00 78.10  ?  372 PRO A O   1 
ATOM   2771 C  CB  . PRO A 1 372 ? -25.041 31.654  19.696  1.00 73.55  ?  372 PRO A CB  1 
ATOM   2772 C  CG  . PRO A 1 372 ? -25.733 31.815  18.357  1.00 73.30  ?  372 PRO A CG  1 
ATOM   2773 C  CD  . PRO A 1 372 ? -25.954 30.399  17.870  1.00 72.47  ?  372 PRO A CD  1 
ATOM   2774 N  N   . HIS A 1 373 ? -23.152 29.878  21.684  1.00 78.74  ?  373 HIS A N   1 
ATOM   2775 C  CA  . HIS A 1 373 ? -22.861 29.141  22.947  1.00 84.91  ?  373 HIS A CA  1 
ATOM   2776 C  C   . HIS A 1 373 ? -24.148 28.946  23.764  1.00 86.93  ?  373 HIS A C   1 
ATOM   2777 O  O   . HIS A 1 373 ? -24.382 27.812  24.238  1.00 85.47  ?  373 HIS A O   1 
ATOM   2778 C  CB  . HIS A 1 373 ? -21.773 29.879  23.745  1.00 88.25  ?  373 HIS A CB  1 
ATOM   2779 C  CG  . HIS A 1 373 ? -21.278 29.152  24.953  1.00 91.60  ?  373 HIS A CG  1 
ATOM   2780 N  ND1 . HIS A 1 373 ? -20.169 28.323  24.915  1.00 90.88  ?  373 HIS A ND1 1 
ATOM   2781 C  CD2 . HIS A 1 373 ? -21.714 29.146  26.233  1.00 92.40  ?  373 HIS A CD2 1 
ATOM   2782 C  CE1 . HIS A 1 373 ? -19.953 27.825  26.118  1.00 91.78  ?  373 HIS A CE1 1 
ATOM   2783 N  NE2 . HIS A 1 373 ? -20.888 28.316  26.946  1.00 94.27  ?  373 HIS A NE2 1 
ATOM   2784 N  N   . ASP A 1 374 ? -24.951 30.007  23.905  1.00 88.14  ?  374 ASP A N   1 
ATOM   2785 C  CA  . ASP A 1 374 ? -26.155 30.054  24.783  1.00 91.57  ?  374 ASP A CA  1 
ATOM   2786 C  C   . ASP A 1 374 ? -27.288 29.184  24.214  1.00 87.53  ?  374 ASP A C   1 
ATOM   2787 O  O   . ASP A 1 374 ? -28.159 28.775  25.005  1.00 91.30  ?  374 ASP A O   1 
ATOM   2788 C  CB  . ASP A 1 374 ? -26.618 31.497  25.022  1.00 99.19  ?  374 ASP A CB  1 
ATOM   2789 C  CG  . ASP A 1 374 ? -26.790 32.334  23.763  1.00 106.61 ?  374 ASP A CG  1 
ATOM   2790 O  OD1 . ASP A 1 374 ? -27.616 31.953  22.907  1.00 108.46 ?  374 ASP A OD1 1 
ATOM   2791 O  OD2 . ASP A 1 374 ? -26.093 33.364  23.650  1.00 113.17 -1 374 ASP A OD2 1 
ATOM   2792 N  N   . ALA A 1 375 ? -27.285 28.906  22.908  1.00 82.85  ?  375 ALA A N   1 
ATOM   2793 C  CA  . ALA A 1 375 ? -28.350 28.148  22.205  1.00 77.09  ?  375 ALA A CA  1 
ATOM   2794 C  C   . ALA A 1 375 ? -28.158 26.638  22.386  1.00 74.75  ?  375 ALA A C   1 
ATOM   2795 O  O   . ALA A 1 375 ? -29.112 25.892  22.095  1.00 75.59  ?  375 ALA A O   1 
ATOM   2796 C  CB  . ALA A 1 375 ? -28.360 28.512  20.742  1.00 78.18  ?  375 ALA A CB  1 
ATOM   2797 N  N   . ILE A 1 376 ? -26.977 26.209  22.843  1.00 72.89  ?  376 ILE A N   1 
ATOM   2798 C  CA  . ILE A 1 376 ? -26.522 24.783  22.809  1.00 72.69  ?  376 ILE A CA  1 
ATOM   2799 C  C   . ILE A 1 376 ? -27.292 23.940  23.825  1.00 71.91  ?  376 ILE A C   1 
ATOM   2800 O  O   . ILE A 1 376 ? -27.778 22.866  23.477  1.00 71.55  ?  376 ILE A O   1 
ATOM   2801 C  CB  . ILE A 1 376 ? -24.994 24.686  23.012  1.00 72.33  ?  376 ILE A CB  1 
ATOM   2802 C  CG1 . ILE A 1 376 ? -24.228 25.412  21.901  1.00 71.29  ?  376 ILE A CG1 1 
ATOM   2803 C  CG2 . ILE A 1 376 ? -24.550 23.235  23.155  1.00 71.73  ?  376 ILE A CG2 1 
ATOM   2804 C  CD1 . ILE A 1 376 ? -24.463 24.863  20.508  1.00 70.56  ?  376 ILE A CD1 1 
ATOM   2805 N  N   . PRO A 1 377 ? -27.427 24.362  25.104  1.00 73.18  ?  377 PRO A N   1 
ATOM   2806 C  CA  . PRO A 1 377 ? -28.122 23.541  26.099  1.00 71.97  ?  377 PRO A CA  1 
ATOM   2807 C  C   . PRO A 1 377 ? -29.553 23.178  25.670  1.00 68.41  ?  377 PRO A C   1 
ATOM   2808 O  O   . PRO A 1 377 ? -29.949 22.051  25.907  1.00 65.56  ?  377 PRO A O   1 
ATOM   2809 C  CB  . PRO A 1 377 ? -28.117 24.415  27.361  1.00 74.80  ?  377 PRO A CB  1 
ATOM   2810 C  CG  . PRO A 1 377 ? -26.929 25.335  27.163  1.00 74.47  ?  377 PRO A CG  1 
ATOM   2811 C  CD  . PRO A 1 377 ? -26.926 25.622  25.676  1.00 74.32  ?  377 PRO A CD  1 
ATOM   2812 N  N   . ARG A 1 378 ? -30.273 24.121  25.046  1.00 66.76  ?  378 ARG A N   1 
ATOM   2813 C  CA  . ARG A 1 378 ? -31.645 23.896  24.500  1.00 66.57  ?  378 ARG A CA  1 
ATOM   2814 C  C   . ARG A 1 378 ? -31.596 22.750  23.481  1.00 67.09  ?  378 ARG A C   1 
ATOM   2815 O  O   . ARG A 1 378 ? -32.370 21.781  23.643  1.00 68.99  ?  378 ARG A O   1 
ATOM   2816 C  CB  . ARG A 1 378 ? -32.205 25.176  23.870  1.00 66.10  ?  378 ARG A CB  1 
ATOM   2817 N  N   . LEU A 1 379 ? -30.702 22.861  22.489  1.00 67.43  ?  379 LEU A N   1 
ATOM   2818 C  CA  . LEU A 1 379 ? -30.439 21.831  21.440  1.00 66.38  ?  379 LEU A CA  1 
ATOM   2819 C  C   . LEU A 1 379 ? -30.103 20.485  22.086  1.00 64.63  ?  379 LEU A C   1 
ATOM   2820 O  O   . LEU A 1 379 ? -30.732 19.481  21.710  1.00 64.03  ?  379 LEU A O   1 
ATOM   2821 C  CB  . LEU A 1 379 ? -29.273 22.280  20.554  1.00 65.92  ?  379 LEU A CB  1 
ATOM   2822 C  CG  . LEU A 1 379 ? -29.661 22.979  19.258  1.00 67.85  ?  379 LEU A CG  1 
ATOM   2823 C  CD1 . LEU A 1 379 ? -28.441 23.611  18.605  1.00 70.04  ?  379 LEU A CD1 1 
ATOM   2824 C  CD2 . LEU A 1 379 ? -30.334 22.003  18.307  1.00 69.27  ?  379 LEU A CD2 1 
ATOM   2825 N  N   . ALA A 1 380 ? -29.115 20.477  22.985  1.00 64.65  ?  380 ALA A N   1 
ATOM   2826 C  CA  . ALA A 1 380 ? -28.623 19.272  23.694  1.00 67.22  ?  380 ALA A CA  1 
ATOM   2827 C  C   . ALA A 1 380 ? -29.810 18.567  24.355  1.00 67.57  ?  380 ALA A C   1 
ATOM   2828 O  O   . ALA A 1 380 ? -29.951 17.339  24.171  1.00 65.67  ?  380 ALA A O   1 
ATOM   2829 C  CB  . ALA A 1 380 ? -27.570 19.653  24.707  1.00 67.46  ?  380 ALA A CB  1 
ATOM   2830 N  N   . ARG A 1 381 ? -30.635 19.337  25.076  1.00 69.52  ?  381 ARG A N   1 
ATOM   2831 C  CA  . ARG A 1 381 ? -31.881 18.853  25.735  1.00 69.94  ?  381 ARG A CA  1 
ATOM   2832 C  C   . ARG A 1 381 ? -32.767 18.193  24.673  1.00 67.44  ?  381 ARG A C   1 
ATOM   2833 O  O   . ARG A 1 381 ? -33.118 17.010  24.842  1.00 67.47  ?  381 ARG A O   1 
ATOM   2834 C  CB  . ARG A 1 381 ? -32.609 20.013  26.425  1.00 69.52  ?  381 ARG A CB  1 
ATOM   2835 N  N   . PHE A 1 382 ? -33.085 18.933  23.608  1.00 65.02  ?  382 PHE A N   1 
ATOM   2836 C  CA  . PHE A 1 382 ? -33.933 18.465  22.482  1.00 64.69  ?  382 PHE A CA  1 
ATOM   2837 C  C   . PHE A 1 382 ? -33.370 17.165  21.897  1.00 63.83  ?  382 PHE A C   1 
ATOM   2838 O  O   . PHE A 1 382 ? -34.159 16.253  21.609  1.00 65.43  ?  382 PHE A O   1 
ATOM   2839 C  CB  . PHE A 1 382 ? -34.048 19.525  21.385  1.00 64.83  ?  382 PHE A CB  1 
ATOM   2840 C  CG  . PHE A 1 382 ? -34.696 19.004  20.129  1.00 66.04  ?  382 PHE A CG  1 
ATOM   2841 C  CD1 . PHE A 1 382 ? -36.074 18.894  20.035  1.00 67.47  ?  382 PHE A CD1 1 
ATOM   2842 C  CD2 . PHE A 1 382 ? -33.926 18.584  19.057  1.00 67.63  ?  382 PHE A CD2 1 
ATOM   2843 C  CE1 . PHE A 1 382 ? -36.668 18.396  18.886  1.00 68.06  ?  382 PHE A CE1 1 
ATOM   2844 C  CE2 . PHE A 1 382 ? -34.522 18.084  17.909  1.00 68.69  ?  382 PHE A CE2 1 
ATOM   2845 C  CZ  . PHE A 1 382 ? -35.890 17.989  17.826  1.00 68.77  ?  382 PHE A CZ  1 
ATOM   2846 N  N   . VAL A 1 383 ? -32.052 17.095  21.696  1.00 66.17  ?  383 VAL A N   1 
ATOM   2847 C  CA  . VAL A 1 383 ? -31.378 15.921  21.063  1.00 67.49  ?  383 VAL A CA  1 
ATOM   2848 C  C   . VAL A 1 383 ? -31.577 14.707  21.977  1.00 67.31  ?  383 VAL A C   1 
ATOM   2849 O  O   . VAL A 1 383 ? -32.031 13.665  21.471  1.00 64.99  ?  383 VAL A O   1 
ATOM   2850 C  CB  . VAL A 1 383 ? -29.890 16.197  20.763  1.00 68.27  ?  383 VAL A CB  1 
ATOM   2851 C  CG1 . VAL A 1 383 ? -29.129 14.933  20.392  1.00 69.00  ?  383 VAL A CG1 1 
ATOM   2852 C  CG2 . VAL A 1 383 ? -29.730 17.232  19.664  1.00 68.70  ?  383 VAL A CG2 1 
ATOM   2853 N  N   . ALA A 1 384 ? -31.280 14.855  23.272  1.00 69.58  ?  384 ALA A N   1 
ATOM   2854 C  CA  . ALA A 1 384 ? -31.440 13.800  24.305  1.00 71.86  ?  384 ALA A CA  1 
ATOM   2855 C  C   . ALA A 1 384 ? -32.883 13.279  24.293  1.00 72.67  ?  384 ALA A C   1 
ATOM   2856 O  O   . ALA A 1 384 ? -33.073 12.062  24.480  1.00 72.86  ?  384 ALA A O   1 
ATOM   2857 C  CB  . ALA A 1 384 ? -31.056 14.327  25.666  1.00 72.32  ?  384 ALA A CB  1 
ATOM   2858 N  N   . SER A 1 385 ? -33.852 14.171  24.067  1.00 73.27  ?  385 SER A N   1 
ATOM   2859 C  CA  . SER A 1 385 ? -35.303 13.843  23.997  1.00 74.75  ?  385 SER A CA  1 
ATOM   2860 C  C   . SER A 1 385 ? -35.590 12.854  22.854  1.00 77.14  ?  385 SER A C   1 
ATOM   2861 O  O   . SER A 1 385 ? -36.078 11.745  23.150  1.00 81.70  ?  385 SER A O   1 
ATOM   2862 C  CB  . SER A 1 385 ? -36.129 15.095  23.873  1.00 73.83  ?  385 SER A CB  1 
ATOM   2863 O  OG  . SER A 1 385 ? -37.458 14.787  23.485  1.00 77.73  ?  385 SER A OG  1 
ATOM   2864 N  N   . VAL A 1 386 ? -35.285 13.228  21.606  1.00 75.97  ?  386 VAL A N   1 
ATOM   2865 C  CA  . VAL A 1 386 ? -35.752 12.515  20.373  1.00 76.34  ?  386 VAL A CA  1 
ATOM   2866 C  C   . VAL A 1 386 ? -34.737 11.456  19.916  1.00 74.29  ?  386 VAL A C   1 
ATOM   2867 O  O   . VAL A 1 386 ? -35.158 10.540  19.187  1.00 69.79  ?  386 VAL A O   1 
ATOM   2868 C  CB  . VAL A 1 386 ? -36.064 13.502  19.230  1.00 78.06  ?  386 VAL A CB  1 
ATOM   2869 C  CG1 . VAL A 1 386 ? -37.114 14.517  19.649  1.00 80.14  ?  386 VAL A CG1 1 
ATOM   2870 C  CG2 . VAL A 1 386 ? -34.820 14.207  18.704  1.00 78.28  ?  386 VAL A CG2 1 
ATOM   2871 N  N   . SER A 1 387 ? -33.460 11.592  20.293  1.00 75.26  ?  387 SER A N   1 
ATOM   2872 C  CA  . SER A 1 387 ? -32.337 10.723  19.831  1.00 75.26  ?  387 SER A CA  1 
ATOM   2873 C  C   . SER A 1 387 ? -32.629 9.247   20.127  1.00 75.38  ?  387 SER A C   1 
ATOM   2874 O  O   . SER A 1 387 ? -32.565 8.434   19.186  1.00 72.95  ?  387 SER A O   1 
ATOM   2875 C  CB  . SER A 1 387 ? -31.027 11.136  20.457  1.00 76.35  ?  387 SER A CB  1 
ATOM   2876 O  OG  . SER A 1 387 ? -30.034 10.138  20.269  1.00 78.73  ?  387 SER A OG  1 
ATOM   2877 N  N   . GLU A 1 388 ? -32.903 8.927   21.396  1.00 78.76  ?  388 GLU A N   1 
ATOM   2878 C  CA  . GLU A 1 388 ? -33.138 7.545   21.902  1.00 80.37  ?  388 GLU A CA  1 
ATOM   2879 C  C   . GLU A 1 388 ? -31.914 6.670   21.598  1.00 77.26  ?  388 GLU A C   1 
ATOM   2880 O  O   . GLU A 1 388 ? -32.110 5.489   21.254  1.00 76.14  ?  388 GLU A O   1 
ATOM   2881 C  CB  . GLU A 1 388 ? -34.413 6.960   21.285  1.00 86.62  ?  388 GLU A CB  1 
ATOM   2882 C  CG  . GLU A 1 388 ? -35.648 7.810   21.528  1.00 91.54  ?  388 GLU A CG  1 
ATOM   2883 C  CD  . GLU A 1 388 ? -36.972 7.177   21.128  1.00 93.93  ?  388 GLU A CD  1 
ATOM   2884 O  OE1 . GLU A 1 388 ? -36.976 6.313   20.225  1.00 90.58  ?  388 GLU A OE1 1 
ATOM   2885 O  OE2 . GLU A 1 388 ? -38.002 7.558   21.721  1.00 99.49  ?  388 GLU A OE2 1 
ATOM   2886 N  N   . GLY A 1 389 ? -30.705 7.236   21.711  1.00 75.30  ?  389 GLY A N   1 
ATOM   2887 C  CA  . GLY A 1 389 ? -29.422 6.512   21.582  1.00 70.98  ?  389 GLY A CA  1 
ATOM   2888 C  C   . GLY A 1 389 ? -29.118 6.097   20.150  1.00 68.10  ?  389 GLY A C   1 
ATOM   2889 O  O   . GLY A 1 389 ? -28.209 5.264   19.955  1.00 70.31  ?  389 GLY A O   1 
ATOM   2890 N  N   . ARG A 1 390 ? -29.842 6.662   19.181  1.00 65.06  ?  390 ARG A N   1 
ATOM   2891 C  CA  . ARG A 1 390 ? -29.603 6.456   17.727  1.00 61.90  ?  390 ARG A CA  1 
ATOM   2892 C  C   . ARG A 1 390 ? -29.122 7.782   17.122  1.00 57.52  ?  390 ARG A C   1 
ATOM   2893 O  O   . ARG A 1 390 ? -29.307 8.841   17.761  1.00 53.86  ?  390 ARG A O   1 
ATOM   2894 C  CB  . ARG A 1 390 ? -30.880 5.931   17.059  1.00 60.75  ?  390 ARG A CB  1 
ATOM   2895 N  N   . VAL A 1 391 ? -28.502 7.729   15.945  1.00 56.09  ?  391 VAL A N   1 
ATOM   2896 C  CA  . VAL A 1 391 ? -28.115 8.945   15.171  1.00 56.06  ?  391 VAL A CA  1 
ATOM   2897 C  C   . VAL A 1 391 ? -29.401 9.700   14.819  1.00 55.23  ?  391 VAL A C   1 
ATOM   2898 O  O   . VAL A 1 391 ? -30.338 9.056   14.322  1.00 56.91  ?  391 VAL A O   1 
ATOM   2899 C  CB  . VAL A 1 391 ? -27.298 8.578   13.918  1.00 55.84  ?  391 VAL A CB  1 
ATOM   2900 C  CG1 . VAL A 1 391 ? -27.152 9.753   12.961  1.00 57.09  ?  391 VAL A CG1 1 
ATOM   2901 C  CG2 . VAL A 1 391 ? -25.935 8.022   14.296  1.00 56.28  ?  391 VAL A CG2 1 
ATOM   2902 N  N   . TRP A 1 392 ? -29.450 11.002  15.103  1.00 54.83  ?  392 TRP A N   1 
ATOM   2903 C  CA  . TRP A 1 392 ? -30.576 11.902  14.737  1.00 55.55  ?  392 TRP A CA  1 
ATOM   2904 C  C   . TRP A 1 392 ? -30.044 13.026  13.846  1.00 55.45  ?  392 TRP A C   1 
ATOM   2905 O  O   . TRP A 1 392 ? -28.942 13.530  14.128  1.00 57.45  ?  392 TRP A O   1 
ATOM   2906 C  CB  . TRP A 1 392 ? -31.273 12.459  15.983  1.00 56.95  ?  392 TRP A CB  1 
ATOM   2907 C  CG  . TRP A 1 392 ? -32.575 13.133  15.677  1.00 58.24  ?  392 TRP A CG  1 
ATOM   2908 C  CD1 . TRP A 1 392 ? -33.811 12.556  15.647  1.00 58.85  ?  392 TRP A CD1 1 
ATOM   2909 C  CD2 . TRP A 1 392 ? -32.771 14.515  15.330  1.00 59.76  ?  392 TRP A CD2 1 
ATOM   2910 N  NE1 . TRP A 1 392 ? -34.761 13.482  15.316  1.00 60.06  ?  392 TRP A NE1 1 
ATOM   2911 C  CE2 . TRP A 1 392 ? -34.155 14.693  15.114  1.00 60.34  ?  392 TRP A CE2 1 
ATOM   2912 C  CE3 . TRP A 1 392 ? -31.919 15.614  15.182  1.00 60.39  ?  392 TRP A CE3 1 
ATOM   2913 C  CZ2 . TRP A 1 392 ? -34.700 15.926  14.760  1.00 61.57  ?  392 TRP A CZ2 1 
ATOM   2914 C  CZ3 . TRP A 1 392 ? -32.460 16.833  14.833  1.00 61.73  ?  392 TRP A CZ3 1 
ATOM   2915 C  CH2 . TRP A 1 392 ? -33.831 16.984  14.623  1.00 61.33  ?  392 TRP A CH2 1 
ATOM   2916 N  N   . ALA A 1 393 ? -30.809 13.401  12.819  1.00 53.47  ?  393 ALA A N   1 
ATOM   2917 C  CA  . ALA A 1 393 ? -30.394 14.370  11.780  1.00 54.31  ?  393 ALA A CA  1 
ATOM   2918 C  C   . ALA A 1 393 ? -31.613 15.084  11.195  1.00 54.90  ?  393 ALA A C   1 
ATOM   2919 O  O   . ALA A 1 393 ? -32.635 14.420  10.939  1.00 56.13  ?  393 ALA A O   1 
ATOM   2920 C  CB  . ALA A 1 393 ? -29.614 13.661  10.701  1.00 54.29  ?  393 ALA A CB  1 
ATOM   2921 N  N   . THR A 1 394 ? -31.483 16.392  10.981  1.00 54.26  ?  394 THR A N   1 
ATOM   2922 C  CA  . THR A 1 394 ? -32.448 17.220  10.211  1.00 53.99  ?  394 THR A CA  1 
ATOM   2923 C  C   . THR A 1 394 ? -31.658 18.209  9.353   1.00 55.11  ?  394 THR A C   1 
ATOM   2924 O  O   . THR A 1 394 ? -30.562 18.611  9.779   1.00 55.68  ?  394 THR A O   1 
ATOM   2925 C  CB  . THR A 1 394 ? -33.446 17.936  11.128  1.00 54.34  ?  394 THR A CB  1 
ATOM   2926 O  OG1 . THR A 1 394 ? -34.479 18.484  10.307  1.00 54.04  ?  394 THR A OG1 1 
ATOM   2927 C  CG2 . THR A 1 394 ? -32.811 19.030  11.959  1.00 54.49  ?  394 THR A CG2 1 
ATOM   2928 N  N   . HIS A 1 395 ? -32.209 18.574  8.196   1.00 56.44  ?  395 HIS A N   1 
ATOM   2929 C  CA  . HIS A 1 395 ? -31.685 19.636  7.298   1.00 59.15  ?  395 HIS A CA  1 
ATOM   2930 C  C   . HIS A 1 395 ? -32.441 20.940  7.564   1.00 58.08  ?  395 HIS A C   1 
ATOM   2931 O  O   . HIS A 1 395 ? -32.102 21.952  6.931   1.00 58.18  ?  395 HIS A O   1 
ATOM   2932 C  CB  . HIS A 1 395 ? -31.786 19.201  5.830   1.00 63.71  ?  395 HIS A CB  1 
ATOM   2933 C  CG  . HIS A 1 395 ? -33.177 18.924  5.368   1.00 66.95  ?  395 HIS A CG  1 
ATOM   2934 N  ND1 . HIS A 1 395 ? -33.813 17.726  5.625   1.00 69.92  ?  395 HIS A ND1 1 
ATOM   2935 C  CD2 . HIS A 1 395 ? -34.052 19.677  4.669   1.00 70.17  ?  395 HIS A CD2 1 
ATOM   2936 C  CE1 . HIS A 1 395 ? -35.025 17.755  5.112   1.00 73.31  ?  395 HIS A CE1 1 
ATOM   2937 N  NE2 . HIS A 1 395 ? -35.197 18.943  4.520   1.00 74.50  ?  395 HIS A NE2 1 
ATOM   2938 N  N   . ALA A 1 396 ? -33.430 20.897  8.461   1.00 58.27  ?  396 ALA A N   1 
ATOM   2939 C  CA  . ALA A 1 396 ? -34.358 22.009  8.772   1.00 60.06  ?  396 ALA A CA  1 
ATOM   2940 C  C   . ALA A 1 396 ? -34.542 22.095  10.288  1.00 59.78  ?  396 ALA A C   1 
ATOM   2941 O  O   . ALA A 1 396 ? -35.507 21.515  10.809  1.00 64.36  ?  396 ALA A O   1 
ATOM   2942 C  CB  . ALA A 1 396 ? -35.671 21.789  8.063   1.00 60.99  ?  396 ALA A CB  1 
ATOM   2943 N  N   . LEU A 1 397 ? -33.633 22.793  10.965  1.00 60.31  ?  397 LEU A N   1 
ATOM   2944 C  CA  . LEU A 1 397 ? -33.562 22.820  12.448  1.00 62.24  ?  397 LEU A CA  1 
ATOM   2945 C  C   . LEU A 1 397 ? -34.749 23.620  12.996  1.00 62.49  ?  397 LEU A C   1 
ATOM   2946 O  O   . LEU A 1 397 ? -35.358 23.162  13.982  1.00 63.94  ?  397 LEU A O   1 
ATOM   2947 C  CB  . LEU A 1 397 ? -32.215 23.415  12.873  1.00 63.95  ?  397 LEU A CB  1 
ATOM   2948 C  CG  . LEU A 1 397 ? -31.748 23.098  14.294  1.00 65.05  ?  397 LEU A CG  1 
ATOM   2949 C  CD1 . LEU A 1 397 ? -31.955 21.631  14.643  1.00 65.96  ?  397 LEU A CD1 1 
ATOM   2950 C  CD2 . LEU A 1 397 ? -30.286 23.479  14.468  1.00 65.73  ?  397 LEU A CD2 1 
ATOM   2951 N  N   . SER A 1 398 ? -35.089 24.738  12.349  1.00 63.11  ?  398 SER A N   1 
ATOM   2952 C  CA  . SER A 1 398 ? -36.188 25.656  12.764  1.00 64.40  ?  398 SER A CA  1 
ATOM   2953 C  C   . SER A 1 398 ? -37.554 24.947  12.727  1.00 65.43  ?  398 SER A C   1 
ATOM   2954 O  O   . SER A 1 398 ? -38.445 25.365  13.492  1.00 68.53  ?  398 SER A O   1 
ATOM   2955 C  CB  . SER A 1 398 ? -36.200 26.912  11.932  1.00 64.16  ?  398 SER A CB  1 
ATOM   2956 O  OG  . SER A 1 398 ? -36.753 26.669  10.647  1.00 65.91  ?  398 SER A OG  1 
ATOM   2957 N  N   . GLN A 1 399 ? -37.724 23.921  11.884  1.00 63.95  ?  399 GLN A N   1 
ATOM   2958 C  CA  . GLN A 1 399 ? -38.969 23.104  11.824  1.00 65.33  ?  399 GLN A CA  1 
ATOM   2959 C  C   . GLN A 1 399 ? -39.108 22.256  13.091  1.00 67.79  ?  399 GLN A C   1 
ATOM   2960 O  O   . GLN A 1 399 ? -40.251 21.908  13.435  1.00 70.76  ?  399 GLN A O   1 
ATOM   2961 C  CB  . GLN A 1 399 ? -38.988 22.177  10.610  1.00 65.54  ?  399 GLN A CB  1 
ATOM   2962 C  CG  . GLN A 1 399 ? -39.538 22.839  9.359   1.00 66.76  ?  399 GLN A CG  1 
ATOM   2963 C  CD  . GLN A 1 399 ? -39.452 21.930  8.158   1.00 66.96  ?  399 GLN A CD  1 
ATOM   2964 O  OE1 . GLN A 1 399 ? -39.614 20.714  8.259   1.00 66.37  ?  399 GLN A OE1 1 
ATOM   2965 N  NE2 . GLN A 1 399 ? -39.191 22.521  7.003   1.00 68.75  ?  399 GLN A NE2 1 
ATOM   2966 N  N   . ALA A 1 400 ? -37.989 21.904  13.726  1.00 70.27  ?  400 ALA A N   1 
ATOM   2967 C  CA  . ALA A 1 400 ? -37.948 21.112  14.977  1.00 73.53  ?  400 ALA A CA  1 
ATOM   2968 C  C   . ALA A 1 400 ? -37.891 22.047  16.192  1.00 75.15  ?  400 ALA A C   1 
ATOM   2969 O  O   . ALA A 1 400 ? -38.545 21.734  17.204  1.00 79.03  ?  400 ALA A O   1 
ATOM   2970 C  CB  . ALA A 1 400 ? -36.777 20.164  14.945  1.00 75.12  ?  400 ALA A CB  1 
ATOM   2971 N  N   . ILE A 1 401 ? -37.132 23.144  16.090  1.00 75.46  ?  401 ILE A N   1 
ATOM   2972 C  CA  . ILE A 1 401 ? -36.946 24.157  17.173  1.00 78.06  ?  401 ILE A CA  1 
ATOM   2973 C  C   . ILE A 1 401 ? -37.163 25.544  16.572  1.00 80.26  ?  401 ILE A C   1 
ATOM   2974 O  O   . ILE A 1 401 ? -36.226 26.151  16.064  1.00 81.81  ?  401 ILE A O   1 
ATOM   2975 C  CB  . ILE A 1 401 ? -35.554 24.013  17.825  1.00 78.24  ?  401 ILE A CB  1 
ATOM   2976 C  CG1 . ILE A 1 401 ? -35.378 22.643  18.485  1.00 79.31  ?  401 ILE A CG1 1 
ATOM   2977 C  CG2 . ILE A 1 401 ? -35.285 25.141  18.811  1.00 77.36  ?  401 ILE A CG2 1 
ATOM   2978 C  CD1 . ILE A 1 401 ? -33.956 22.339  18.891  1.00 80.96  ?  401 ILE A CD1 1 
ATOM   2979 N  N   . PRO A 1 402 ? -38.401 26.089  16.611  1.00 83.09  ?  402 PRO A N   1 
ATOM   2980 C  CA  . PRO A 1 402 ? -38.700 27.381  15.988  1.00 83.66  ?  402 PRO A CA  1 
ATOM   2981 C  C   . PRO A 1 402 ? -37.714 28.518  16.301  1.00 85.07  ?  402 PRO A C   1 
ATOM   2982 O  O   . PRO A 1 402 ? -37.473 29.315  15.412  1.00 86.90  ?  402 PRO A O   1 
ATOM   2983 C  CB  . PRO A 1 402 ? -40.090 27.717  16.547  1.00 84.81  ?  402 PRO A CB  1 
ATOM   2984 C  CG  . PRO A 1 402 ? -40.724 26.362  16.770  1.00 85.15  ?  402 PRO A CG  1 
ATOM   2985 C  CD  . PRO A 1 402 ? -39.584 25.487  17.248  1.00 84.54  ?  402 PRO A CD  1 
ATOM   2986 N  N   . GLU A 1 403 ? -37.162 28.570  17.520  1.00 85.30  ?  403 GLU A N   1 
ATOM   2987 C  CA  . GLU A 1 403 ? -36.235 29.659  17.941  1.00 88.18  ?  403 GLU A CA  1 
ATOM   2988 C  C   . GLU A 1 403 ? -34.877 29.489  17.242  1.00 85.37  ?  403 GLU A C   1 
ATOM   2989 O  O   . GLU A 1 403 ? -34.100 30.460  17.246  1.00 82.86  ?  403 GLU A O   1 
ATOM   2990 C  CB  . GLU A 1 403 ? -36.091 29.734  19.466  1.00 92.22  ?  403 GLU A CB  1 
ATOM   2991 C  CG  . GLU A 1 403 ? -35.426 28.528  20.110  1.00 98.16  ?  403 GLU A CG  1 
ATOM   2992 C  CD  . GLU A 1 403 ? -36.287 27.750  21.093  1.00 104.13 ?  403 GLU A CD  1 
ATOM   2993 O  OE1 . GLU A 1 403 ? -37.505 27.623  20.844  1.00 104.97 ?  403 GLU A OE1 1 
ATOM   2994 O  OE2 . GLU A 1 403 ? -35.735 27.271  22.113  1.00 107.13 -1 403 GLU A OE2 1 
ATOM   2995 N  N   . ALA A 1 404 ? -34.617 28.317  16.646  1.00 82.08  ?  404 ALA A N   1 
ATOM   2996 C  CA  . ALA A 1 404 ? -33.369 27.988  15.911  1.00 79.77  ?  404 ALA A CA  1 
ATOM   2997 C  C   . ALA A 1 404 ? -33.307 28.757  14.583  1.00 81.73  ?  404 ALA A C   1 
ATOM   2998 O  O   . ALA A 1 404 ? -32.217 28.793  13.977  1.00 85.38  ?  404 ALA A O   1 
ATOM   2999 C  CB  . ALA A 1 404 ? -33.274 26.499  15.681  1.00 77.62  ?  404 ALA A CB  1 
ATOM   3000 N  N   . GLU A 1 405 ? -34.438 29.324  14.146  1.00 80.27  ?  405 GLU A N   1 
ATOM   3001 C  CA  . GLU A 1 405 ? -34.562 30.197  12.945  1.00 77.57  ?  405 GLU A CA  1 
ATOM   3002 C  C   . GLU A 1 405 ? -33.547 31.343  13.029  1.00 74.65  ?  405 GLU A C   1 
ATOM   3003 O  O   . GLU A 1 405 ? -32.980 31.712  11.983  1.00 71.15  ?  405 GLU A O   1 
ATOM   3004 C  CB  . GLU A 1 405 ? -35.994 30.734  12.851  1.00 81.37  ?  405 GLU A CB  1 
ATOM   3005 C  CG  . GLU A 1 405 ? -36.193 31.814  11.800  1.00 84.18  ?  405 GLU A CG  1 
ATOM   3006 C  CD  . GLU A 1 405 ? -37.638 32.228  11.572  1.00 86.11  ?  405 GLU A CD  1 
ATOM   3007 O  OE1 . GLU A 1 405 ? -38.529 31.693  12.268  1.00 84.88  ?  405 GLU A OE1 1 
ATOM   3008 O  OE2 . GLU A 1 405 ? -37.869 33.084  10.691  1.00 85.94  -1 405 GLU A OE2 1 
ATOM   3009 N  N   . ILE A 1 406 ? -33.334 31.878  14.234  1.00 76.14  ?  406 ILE A N   1 
ATOM   3010 C  CA  . ILE A 1 406 ? -32.510 33.099  14.491  1.00 76.73  ?  406 ILE A CA  1 
ATOM   3011 C  C   . ILE A 1 406 ? -31.076 32.892  13.970  1.00 71.87  ?  406 ILE A C   1 
ATOM   3012 O  O   . ILE A 1 406 ? -30.486 33.887  13.509  1.00 69.42  ?  406 ILE A O   1 
ATOM   3013 C  CB  . ILE A 1 406 ? -32.554 33.483  15.989  1.00 80.86  ?  406 ILE A CB  1 
ATOM   3014 C  CG1 . ILE A 1 406 ? -32.015 34.894  16.242  1.00 84.96  ?  406 ILE A CG1 1 
ATOM   3015 C  CG2 . ILE A 1 406 ? -31.836 32.454  16.850  1.00 83.13  ?  406 ILE A CG2 1 
ATOM   3016 C  CD1 . ILE A 1 406 ? -32.902 36.001  15.718  1.00 88.26  ?  406 ILE A CD1 1 
ATOM   3017 N  N   . TYR A 1 407 ? -30.539 31.666  14.021  1.00 68.79  ?  407 TYR A N   1 
ATOM   3018 C  CA  . TYR A 1 407 ? -29.115 31.370  13.690  1.00 69.00  ?  407 TYR A CA  1 
ATOM   3019 C  C   . TYR A 1 407 ? -29.004 30.434  12.474  1.00 69.91  ?  407 TYR A C   1 
ATOM   3020 O  O   . TYR A 1 407 ? -27.943 29.793  12.307  1.00 68.65  ?  407 TYR A O   1 
ATOM   3021 C  CB  . TYR A 1 407 ? -28.368 30.839  14.920  1.00 68.33  ?  407 TYR A CB  1 
ATOM   3022 C  CG  . TYR A 1 407 ? -28.955 29.641  15.627  1.00 67.92  ?  407 TYR A CG  1 
ATOM   3023 C  CD1 . TYR A 1 407 ? -28.832 28.361  15.109  1.00 69.34  ?  407 TYR A CD1 1 
ATOM   3024 C  CD2 . TYR A 1 407 ? -29.574 29.776  16.859  1.00 68.92  ?  407 TYR A CD2 1 
ATOM   3025 C  CE1 . TYR A 1 407 ? -29.345 27.256  15.771  1.00 68.92  ?  407 TYR A CE1 1 
ATOM   3026 C  CE2 . TYR A 1 407 ? -30.088 28.682  17.538  1.00 68.67  ?  407 TYR A CE2 1 
ATOM   3027 C  CZ  . TYR A 1 407 ? -29.972 27.415  16.995  1.00 69.38  ?  407 TYR A CZ  1 
ATOM   3028 O  OH  . TYR A 1 407 ? -30.480 26.333  17.656  1.00 68.88  ?  407 TYR A OH  1 
ATOM   3029 N  N   . ALA A 1 408 ? -30.025 30.403  11.612  1.00 70.42  ?  408 ALA A N   1 
ATOM   3030 C  CA  . ALA A 1 408 ? -30.108 29.506  10.432  1.00 73.85  ?  408 ALA A CA  1 
ATOM   3031 C  C   . ALA A 1 408 ? -28.965 29.793  9.443   1.00 75.78  ?  408 ALA A C   1 
ATOM   3032 O  O   . ALA A 1 408 ? -28.507 28.841  8.784   1.00 76.29  ?  408 ALA A O   1 
ATOM   3033 C  CB  . ALA A 1 408 ? -31.455 29.643  9.766   1.00 74.72  ?  408 ALA A CB  1 
ATOM   3034 N  N   . ASP A 1 409 ? -28.516 31.048  9.347   1.00 76.85  ?  409 ASP A N   1 
ATOM   3035 C  CA  . ASP A 1 409 ? -27.426 31.482  8.427   1.00 77.06  ?  409 ASP A CA  1 
ATOM   3036 C  C   . ASP A 1 409 ? -26.106 30.796  8.807   1.00 75.25  ?  409 ASP A C   1 
ATOM   3037 O  O   . ASP A 1 409 ? -25.238 30.667  7.923   1.00 79.04  ?  409 ASP A O   1 
ATOM   3038 C  CB  . ASP A 1 409 ? -27.269 33.005  8.428   1.00 78.22  ?  409 ASP A CB  1 
ATOM   3039 C  CG  . ASP A 1 409 ? -26.922 33.591  9.786   1.00 81.05  ?  409 ASP A CG  1 
ATOM   3040 O  OD1 . ASP A 1 409 ? -27.363 33.018  10.805  1.00 81.57  ?  409 ASP A OD1 1 
ATOM   3041 O  OD2 . ASP A 1 409 ? -26.216 34.617  9.813   1.00 86.94  ?  409 ASP A OD2 1 
ATOM   3042 N  N   . THR A 1 410 ? -25.969 30.375  10.069  1.00 71.91  ?  410 THR A N   1 
ATOM   3043 C  CA  . THR A 1 410 ? -24.751 29.720  10.628  1.00 69.09  ?  410 THR A CA  1 
ATOM   3044 C  C   . THR A 1 410 ? -24.967 28.203  10.709  1.00 64.81  ?  410 THR A C   1 
ATOM   3045 O  O   . THR A 1 410 ? -24.021 27.455  10.389  1.00 64.23  ?  410 THR A O   1 
ATOM   3046 C  CB  . THR A 1 410 ? -24.396 30.308  11.999  1.00 70.85  ?  410 THR A CB  1 
ATOM   3047 O  OG1 . THR A 1 410 ? -24.197 31.708  11.807  1.00 74.43  ?  410 THR A OG1 1 
ATOM   3048 C  CG2 . THR A 1 410 ? -23.163 29.692  12.625  1.00 71.51  ?  410 THR A CG2 1 
ATOM   3049 N  N   . ALA A 1 411 ? -26.156 27.770  11.139  1.00 60.66  ?  411 ALA A N   1 
ATOM   3050 C  CA  . ALA A 1 411 ? -26.494 26.347  11.380  1.00 58.55  ?  411 ALA A CA  1 
ATOM   3051 C  C   . ALA A 1 411 ? -27.987 26.112  11.144  1.00 57.30  ?  411 ALA A C   1 
ATOM   3052 O  O   . ALA A 1 411 ? -28.781 26.364  12.069  1.00 63.64  ?  411 ALA A O   1 
ATOM   3053 C  CB  . ALA A 1 411 ? -26.086 25.959  12.780  1.00 58.52  ?  411 ALA A CB  1 
ATOM   3054 N  N   . ALA A 1 412 ? -28.340 25.651  9.943   1.00 56.19  ?  412 ALA A N   1 
ATOM   3055 C  CA  . ALA A 1 412 ? -29.726 25.338  9.518   1.00 56.34  ?  412 ALA A CA  1 
ATOM   3056 C  C   . ALA A 1 412 ? -29.970 23.825  9.576   1.00 57.09  ?  412 ALA A C   1 
ATOM   3057 O  O   . ALA A 1 412 ? -31.144 23.412  9.625   1.00 57.31  ?  412 ALA A O   1 
ATOM   3058 C  CB  . ALA A 1 412 ? -29.967 25.872  8.130   1.00 56.96  ?  412 ALA A CB  1 
ATOM   3059 N  N   . GLY A 1 413 ? -28.897 23.032  9.534   1.00 57.60  ?  413 GLY A N   1 
ATOM   3060 C  CA  . GLY A 1 413 ? -28.953 21.560  9.577   1.00 56.35  ?  413 GLY A CA  1 
ATOM   3061 C  C   . GLY A 1 413 ? -28.032 21.017  10.649  1.00 56.07  ?  413 GLY A C   1 
ATOM   3062 O  O   . GLY A 1 413 ? -26.974 21.627  10.880  1.00 58.41  ?  413 GLY A O   1 
ATOM   3063 N  N   . MET A 1 414 ? -28.427 19.917  11.287  1.00 55.64  ?  414 MET A N   1 
ATOM   3064 C  CA  . MET A 1 414 ? -27.662 19.274  12.384  1.00 55.57  ?  414 MET A CA  1 
ATOM   3065 C  C   . MET A 1 414 ? -27.764 17.754  12.234  1.00 54.08  ?  414 MET A C   1 
ATOM   3066 O  O   . MET A 1 414 ? -28.849 17.273  11.866  1.00 53.07  ?  414 MET A O   1 
ATOM   3067 C  CB  . MET A 1 414 ? -28.219 19.697  13.747  1.00 58.41  ?  414 MET A CB  1 
ATOM   3068 C  CG  . MET A 1 414 ? -27.456 19.128  14.930  1.00 61.27  ?  414 MET A CG  1 
ATOM   3069 S  SD  . MET A 1 414 ? -28.139 19.679  16.513  1.00 62.36  ?  414 MET A SD  1 
ATOM   3070 C  CE  . MET A 1 414 ? -29.644 18.708  16.574  1.00 62.12  ?  414 MET A CE  1 
ATOM   3071 N  N   . LEU A 1 415 ? -26.655 17.052  12.475  1.00 53.98  ?  415 LEU A N   1 
ATOM   3072 C  CA  . LEU A 1 415 ? -26.600 15.578  12.662  1.00 54.23  ?  415 LEU A CA  1 
ATOM   3073 C  C   . LEU A 1 415 ? -25.945 15.316  14.018  1.00 54.93  ?  415 LEU A C   1 
ATOM   3074 O  O   . LEU A 1 415 ? -24.815 15.802  14.226  1.00 55.34  ?  415 LEU A O   1 
ATOM   3075 C  CB  . LEU A 1 415 ? -25.811 14.928  11.519  1.00 54.89  ?  415 LEU A CB  1 
ATOM   3076 C  CG  . LEU A 1 415 ? -25.665 13.406  11.596  1.00 57.60  ?  415 LEU A CG  1 
ATOM   3077 C  CD1 . LEU A 1 415 ? -25.647 12.781  10.208  1.00 57.89  ?  415 LEU A CD1 1 
ATOM   3078 C  CD2 . LEU A 1 415 ? -24.414 13.004  12.367  1.00 58.52  ?  415 LEU A CD2 1 
ATOM   3079 N  N   . ALA A 1 416 ? -26.641 14.598  14.902  1.00 54.62  ?  416 ALA A N   1 
ATOM   3080 C  CA  . ALA A 1 416 ? -26.199 14.297  16.283  1.00 54.83  ?  416 ALA A CA  1 
ATOM   3081 C  C   . ALA A 1 416 ? -25.806 12.821  16.381  1.00 54.49  ?  416 ALA A C   1 
ATOM   3082 O  O   . ALA A 1 416 ? -26.622 11.957  16.008  1.00 55.40  ?  416 ALA A O   1 
ATOM   3083 C  CB  . ALA A 1 416 ? -27.288 14.652  17.264  1.00 55.64  ?  416 ALA A CB  1 
ATOM   3084 N  N   . ILE A 1 417 ? -24.586 12.559  16.848  1.00 55.32  ?  417 ILE A N   1 
ATOM   3085 C  CA  . ILE A 1 417 ? -24.062 11.190  17.125  1.00 56.19  ?  417 ILE A CA  1 
ATOM   3086 C  C   . ILE A 1 417 ? -23.954 11.038  18.638  1.00 57.63  ?  417 ILE A C   1 
ATOM   3087 O  O   . ILE A 1 417 ? -23.199 11.772  19.267  1.00 56.94  ?  417 ILE A O   1 
ATOM   3088 C  CB  . ILE A 1 417 ? -22.708 10.957  16.425  1.00 55.13  ?  417 ILE A CB  1 
ATOM   3089 C  CG1 . ILE A 1 417 ? -22.787 11.270  14.929  1.00 54.02  ?  417 ILE A CG1 1 
ATOM   3090 C  CG2 . ILE A 1 417 ? -22.209 9.541   16.682  1.00 57.25  ?  417 ILE A CG2 1 
ATOM   3091 C  CD1 . ILE A 1 417 ? -21.532 10.936  14.161  1.00 55.25  ?  417 ILE A CD1 1 
ATOM   3092 N  N   . PRO A 1 418 ? -24.703 10.099  19.265  1.00 60.52  ?  418 PRO A N   1 
ATOM   3093 C  CA  . PRO A 1 418 ? -24.497 9.765   20.672  1.00 62.04  ?  418 PRO A CA  1 
ATOM   3094 C  C   . PRO A 1 418 ? -23.153 9.043   20.829  1.00 63.21  ?  418 PRO A C   1 
ATOM   3095 O  O   . PRO A 1 418 ? -22.928 8.099   20.097  1.00 65.66  ?  418 PRO A O   1 
ATOM   3096 C  CB  . PRO A 1 418 ? -25.659 8.829   21.040  1.00 62.25  ?  418 PRO A CB  1 
ATOM   3097 C  CG  . PRO A 1 418 ? -26.613 8.892   19.861  1.00 62.54  ?  418 PRO A CG  1 
ATOM   3098 C  CD  . PRO A 1 418 ? -25.785 9.307   18.664  1.00 61.68  ?  418 PRO A CD  1 
ATOM   3099 N  N   . ILE A 1 419 ? -22.305 9.503   21.754  1.00 62.86  ?  419 ILE A N   1 
ATOM   3100 C  CA  . ILE A 1 419 ? -20.917 8.977   21.942  1.00 64.96  ?  419 ILE A CA  1 
ATOM   3101 C  C   . ILE A 1 419 ? -20.832 8.179   23.248  1.00 66.97  ?  419 ILE A C   1 
ATOM   3102 O  O   . ILE A 1 419 ? -19.729 7.691   23.563  1.00 67.53  ?  419 ILE A O   1 
ATOM   3103 C  CB  . ILE A 1 419 ? -19.880 10.116  21.879  1.00 64.48  ?  419 ILE A CB  1 
ATOM   3104 C  CG1 . ILE A 1 419 ? -20.034 11.120  23.024  1.00 62.98  ?  419 ILE A CG1 1 
ATOM   3105 C  CG2 . ILE A 1 419 ? -19.942 10.797  20.523  1.00 66.49  ?  419 ILE A CG2 1 
ATOM   3106 C  CD1 . ILE A 1 419 ? -19.109 12.306  22.923  1.00 63.05  ?  419 ILE A CD1 1 
ATOM   3107 N  N   . SER A 1 420 ? -21.950 8.029   23.963  1.00 69.90  ?  420 SER A N   1 
ATOM   3108 C  CA  . SER A 1 420 ? -22.035 7.244   25.224  1.00 73.90  ?  420 SER A CA  1 
ATOM   3109 C  C   . SER A 1 420 ? -23.367 6.497   25.303  1.00 75.88  ?  420 SER A C   1 
ATOM   3110 O  O   . SER A 1 420 ? -24.408 7.093   24.967  1.00 74.71  ?  420 SER A O   1 
ATOM   3111 C  CB  . SER A 1 420 ? -21.851 8.120   26.430  1.00 77.19  ?  420 SER A CB  1 
ATOM   3112 O  OG  . SER A 1 420 ? -21.868 7.340   27.615  1.00 80.70  ?  420 SER A OG  1 
ATOM   3113 N  N   . GLN A 1 421 ? -23.316 5.244   25.759  1.00 80.71  ?  421 GLN A N   1 
ATOM   3114 C  CA  . GLN A 1 421 ? -24.507 4.418   26.094  1.00 82.76  ?  421 GLN A CA  1 
ATOM   3115 C  C   . GLN A 1 421 ? -25.166 5.011   27.354  1.00 83.37  ?  421 GLN A C   1 
ATOM   3116 O  O   . GLN A 1 421 ? -26.399 5.193   27.348  1.00 81.99  ?  421 GLN A O   1 
ATOM   3117 C  CB  . GLN A 1 421 ? -24.081 2.953   26.262  1.00 85.12  ?  421 GLN A CB  1 
ATOM   3118 C  CG  . GLN A 1 421 ? -25.162 1.936   25.921  1.00 88.30  ?  421 GLN A CG  1 
ATOM   3119 C  CD  . GLN A 1 421 ? -25.371 1.761   24.435  1.00 90.35  ?  421 GLN A CD  1 
ATOM   3120 O  OE1 . GLN A 1 421 ? -25.114 2.661   23.640  1.00 91.74  ?  421 GLN A OE1 1 
ATOM   3121 N  NE2 . GLN A 1 421 ? -25.860 0.594   24.045  1.00 92.76  ?  421 GLN A NE2 1 
ATOM   3122 N  N   . VAL A 1 422 ? -24.358 5.362   28.367  1.00 84.79  ?  422 VAL A N   1 
ATOM   3123 C  CA  . VAL A 1 422 ? -24.804 5.704   29.758  1.00 86.23  ?  422 VAL A CA  1 
ATOM   3124 C  C   . VAL A 1 422 ? -25.282 7.170   29.878  1.00 86.82  ?  422 VAL A C   1 
ATOM   3125 O  O   . VAL A 1 422 ? -26.465 7.376   30.235  1.00 89.30  ?  422 VAL A O   1 
ATOM   3126 C  CB  . VAL A 1 422 ? -23.688 5.420   30.787  1.00 81.95  ?  422 VAL A CB  1 
ATOM   3127 N  N   . LYS A 1 423 ? -24.383 8.141   29.665  1.00 86.88  ?  423 LYS A N   1 
ATOM   3128 C  CA  . LYS A 1 423 ? -24.678 9.598   29.806  1.00 84.44  ?  423 LYS A CA  1 
ATOM   3129 C  C   . LYS A 1 423 ? -25.182 10.138  28.460  1.00 80.83  ?  423 LYS A C   1 
ATOM   3130 O  O   . LYS A 1 423 ? -25.086 9.405   27.455  1.00 79.18  ?  423 LYS A O   1 
ATOM   3131 C  CB  . LYS A 1 423 ? -23.439 10.355  30.298  1.00 80.65  ?  423 LYS A CB  1 
ATOM   3132 N  N   . SER A 1 424 ? -25.717 11.363  28.457  1.00 78.20  ?  424 SER A N   1 
ATOM   3133 C  CA  . SER A 1 424 ? -26.260 12.050  27.248  1.00 78.60  ?  424 SER A CA  1 
ATOM   3134 C  C   . SER A 1 424 ? -25.208 12.993  26.645  1.00 73.49  ?  424 SER A C   1 
ATOM   3135 O  O   . SER A 1 424 ? -25.471 14.214  26.551  1.00 67.79  ?  424 SER A O   1 
ATOM   3136 C  CB  . SER A 1 424 ? -27.541 12.780  27.568  1.00 81.94  ?  424 SER A CB  1 
ATOM   3137 O  OG  . SER A 1 424 ? -27.285 13.942  28.344  1.00 86.61  ?  424 SER A OG  1 
ATOM   3138 N  N   . ASP A 1 425 ? -24.062 12.435  26.244  1.00 68.17  ?  425 ASP A N   1 
ATOM   3139 C  CA  . ASP A 1 425 ? -22.978 13.159  25.531  1.00 65.35  ?  425 ASP A CA  1 
ATOM   3140 C  C   . ASP A 1 425 ? -23.173 12.975  24.024  1.00 63.52  ?  425 ASP A C   1 
ATOM   3141 O  O   . ASP A 1 425 ? -23.523 11.849  23.607  1.00 62.70  ?  425 ASP A O   1 
ATOM   3142 C  CB  . ASP A 1 425 ? -21.598 12.654  25.951  1.00 67.06  ?  425 ASP A CB  1 
ATOM   3143 C  CG  . ASP A 1 425 ? -21.311 12.796  27.433  1.00 66.78  ?  425 ASP A CG  1 
ATOM   3144 O  OD1 . ASP A 1 425 ? -21.756 13.806  28.026  1.00 60.00  ?  425 ASP A OD1 1 
ATOM   3145 O  OD2 . ASP A 1 425 ? -20.637 11.894  27.977  1.00 69.75  -1 425 ASP A OD2 1 
ATOM   3146 N  N   . TYR A 1 426 ? -22.935 14.032  23.243  1.00 61.37  ?  426 TYR A N   1 
ATOM   3147 C  CA  . TYR A 1 426 ? -23.191 14.064  21.779  1.00 62.05  ?  426 TYR A CA  1 
ATOM   3148 C  C   . TYR A 1 426 ? -22.019 14.713  21.034  1.00 59.92  ?  426 TYR A C   1 
ATOM   3149 O  O   . TYR A 1 426 ? -21.409 15.681  21.529  1.00 60.66  ?  426 TYR A O   1 
ATOM   3150 C  CB  . TYR A 1 426 ? -24.519 14.771  21.490  1.00 64.44  ?  426 TYR A CB  1 
ATOM   3151 C  CG  . TYR A 1 426 ? -25.724 14.001  21.967  1.00 66.94  ?  426 TYR A CG  1 
ATOM   3152 C  CD1 . TYR A 1 426 ? -26.195 12.910  21.256  1.00 69.29  ?  426 TYR A CD1 1 
ATOM   3153 C  CD2 . TYR A 1 426 ? -26.368 14.332  23.148  1.00 68.93  ?  426 TYR A CD2 1 
ATOM   3154 C  CE1 . TYR A 1 426 ? -27.284 12.176  21.697  1.00 72.08  ?  426 TYR A CE1 1 
ATOM   3155 C  CE2 . TYR A 1 426 ? -27.456 13.607  23.606  1.00 71.90  ?  426 TYR A CE2 1 
ATOM   3156 C  CZ  . TYR A 1 426 ? -27.917 12.524  22.877  1.00 74.14  ?  426 TYR A CZ  1 
ATOM   3157 O  OH  . TYR A 1 426 ? -28.991 11.798  23.311  1.00 78.57  ?  426 TYR A OH  1 
ATOM   3158 N  N   . LEU A 1 427 ? -21.712 14.157  19.863  1.00 57.80  ?  427 LEU A N   1 
ATOM   3159 C  CA  . LEU A 1 427 ? -20.907 14.806  18.799  1.00 57.23  ?  427 LEU A CA  1 
ATOM   3160 C  C   . LEU A 1 427 ? -21.890 15.393  17.783  1.00 54.51  ?  427 LEU A C   1 
ATOM   3161 O  O   . LEU A 1 427 ? -22.652 14.616  17.190  1.00 56.08  ?  427 LEU A O   1 
ATOM   3162 C  CB  . LEU A 1 427 ? -19.986 13.752  18.176  1.00 58.22  ?  427 LEU A CB  1 
ATOM   3163 C  CG  . LEU A 1 427 ? -18.881 14.278  17.265  1.00 61.55  ?  427 LEU A CG  1 
ATOM   3164 C  CD1 . LEU A 1 427 ? -17.878 15.121  18.042  1.00 61.92  ?  427 LEU A CD1 1 
ATOM   3165 C  CD2 . LEU A 1 427 ? -18.176 13.123  16.571  1.00 63.81  ?  427 LEU A CD2 1 
ATOM   3166 N  N   . LEU A 1 428 ? -21.910 16.718  17.634  1.00 54.05  ?  428 LEU A N   1 
ATOM   3167 C  CA  . LEU A 1 428 ? -22.883 17.440  16.771  1.00 53.94  ?  428 LEU A CA  1 
ATOM   3168 C  C   . LEU A 1 428 ? -22.166 17.978  15.528  1.00 54.32  ?  428 LEU A C   1 
ATOM   3169 O  O   . LEU A 1 428 ? -21.105 18.615  15.673  1.00 53.66  ?  428 LEU A O   1 
ATOM   3170 C  CB  . LEU A 1 428 ? -23.533 18.572  17.571  1.00 54.24  ?  428 LEU A CB  1 
ATOM   3171 C  CG  . LEU A 1 428 ? -24.249 18.150  18.853  1.00 55.03  ?  428 LEU A CG  1 
ATOM   3172 C  CD1 . LEU A 1 428 ? -24.824 19.362  19.568  1.00 56.45  ?  428 LEU A CD1 1 
ATOM   3173 C  CD2 . LEU A 1 428 ? -25.345 17.136  18.564  1.00 55.28  ?  428 LEU A CD2 1 
ATOM   3174 N  N   . PHE A 1 429 ? -22.739 17.707  14.355  1.00 52.91  ?  429 PHE A N   1 
ATOM   3175 C  CA  . PHE A 1 429 ? -22.290 18.203  13.032  1.00 51.47  ?  429 PHE A CA  1 
ATOM   3176 C  C   . PHE A 1 429 ? -23.318 19.206  12.512  1.00 51.00  ?  429 PHE A C   1 
ATOM   3177 O  O   . PHE A 1 429 ? -24.519 18.906  12.577  1.00 52.75  ?  429 PHE A O   1 
ATOM   3178 C  CB  . PHE A 1 429 ? -22.131 17.041  12.054  1.00 51.60  ?  429 PHE A CB  1 
ATOM   3179 C  CG  . PHE A 1 429 ? -21.048 16.066  12.425  1.00 51.64  ?  429 PHE A CG  1 
ATOM   3180 C  CD1 . PHE A 1 429 ? -21.301 15.033  13.311  1.00 54.72  ?  429 PHE A CD1 1 
ATOM   3181 C  CD2 . PHE A 1 429 ? -19.777 16.181  11.888  1.00 51.73  ?  429 PHE A CD2 1 
ATOM   3182 C  CE1 . PHE A 1 429 ? -20.303 14.131  13.648  1.00 55.86  ?  429 PHE A CE1 1 
ATOM   3183 C  CE2 . PHE A 1 429 ? -18.783 15.277  12.224  1.00 53.79  ?  429 PHE A CE2 1 
ATOM   3184 C  CZ  . PHE A 1 429 ? -19.047 14.253  13.102  1.00 54.98  ?  429 PHE A CZ  1 
ATOM   3185 N  N   . PHE A 1 430 ? -22.850 20.341  11.995  1.00 50.44  ?  430 PHE A N   1 
ATOM   3186 C  CA  . PHE A 1 430 ? -23.704 21.477  11.571  1.00 50.18  ?  430 PHE A CA  1 
ATOM   3187 C  C   . PHE A 1 430 ? -23.450 21.815  10.100  1.00 51.14  ?  430 PHE A C   1 
ATOM   3188 O  O   . PHE A 1 430 ? -22.304 21.699  9.622   1.00 50.10  ?  430 PHE A O   1 
ATOM   3189 C  CB  . PHE A 1 430 ? -23.456 22.675  12.484  1.00 51.07  ?  430 PHE A CB  1 
ATOM   3190 C  CG  . PHE A 1 430 ? -23.882 22.449  13.909  1.00 52.38  ?  430 PHE A CG  1 
ATOM   3191 C  CD1 . PHE A 1 430 ? -25.225 22.426  14.251  1.00 53.34  ?  430 PHE A CD1 1 
ATOM   3192 C  CD2 . PHE A 1 430 ? -22.942 22.254  14.907  1.00 55.24  ?  430 PHE A CD2 1 
ATOM   3193 C  CE1 . PHE A 1 430 ? -25.621 22.218  15.563  1.00 54.57  ?  430 PHE A CE1 1 
ATOM   3194 C  CE2 . PHE A 1 430 ? -23.339 22.050  16.220  1.00 56.64  ?  430 PHE A CE2 1 
ATOM   3195 C  CZ  . PHE A 1 430 ? -24.676 22.031  16.546  1.00 56.27  ?  430 PHE A CZ  1 
ATOM   3196 N  N   . ARG A 1 431 ? -24.516 22.221  9.408   1.00 51.20  ?  431 ARG A N   1 
ATOM   3197 C  CA  . ARG A 1 431 ? -24.462 22.735  8.015   1.00 51.04  ?  431 ARG A CA  1 
ATOM   3198 C  C   . ARG A 1 431 ? -25.187 24.082  7.972   1.00 53.48  ?  431 ARG A C   1 
ATOM   3199 O  O   . ARG A 1 431 ? -26.279 24.188  8.572   1.00 52.55  ?  431 ARG A O   1 
ATOM   3200 C  CB  . ARG A 1 431 ? -25.072 21.734  7.033   1.00 49.24  ?  431 ARG A CB  1 
ATOM   3201 C  CG  . ARG A 1 431 ? -24.144 20.579  6.693   1.00 49.47  ?  431 ARG A CG  1 
ATOM   3202 C  CD  . ARG A 1 431 ? -24.763 19.626  5.693   1.00 50.29  ?  431 ARG A CD  1 
ATOM   3203 N  NE  . ARG A 1 431 ? -23.871 18.507  5.419   1.00 52.95  ?  431 ARG A NE  1 
ATOM   3204 C  CZ  . ARG A 1 431 ? -24.184 17.434  4.696   1.00 53.21  ?  431 ARG A CZ  1 
ATOM   3205 N  NH1 . ARG A 1 431 ? -25.388 17.312  4.157   1.00 53.21  ?  431 ARG A NH1 1 
ATOM   3206 N  NH2 . ARG A 1 431 ? -23.285 16.481  4.518   1.00 52.68  ?  431 ARG A NH2 1 
ATOM   3207 N  N   . LYS A 1 432 ? -24.572 25.066  7.311   1.00 54.78  ?  432 LYS A N   1 
ATOM   3208 C  CA  . LYS A 1 432 ? -25.156 26.407  7.059   1.00 56.12  ?  432 LYS A CA  1 
ATOM   3209 C  C   . LYS A 1 432 ? -26.390 26.244  6.173   1.00 55.76  ?  432 LYS A C   1 
ATOM   3210 O  O   . LYS A 1 432 ? -26.520 25.191  5.523   1.00 52.65  ?  432 LYS A O   1 
ATOM   3211 C  CB  . LYS A 1 432 ? -24.153 27.326  6.357   1.00 59.76  ?  432 LYS A CB  1 
ATOM   3212 C  CG  . LYS A 1 432 ? -22.972 27.784  7.199   1.00 63.12  ?  432 LYS A CG  1 
ATOM   3213 C  CD  . LYS A 1 432 ? -21.914 28.483  6.377   1.00 67.36  ?  432 LYS A CD  1 
ATOM   3214 C  CE  . LYS A 1 432 ? -20.928 29.275  7.208   1.00 71.69  ?  432 LYS A CE  1 
ATOM   3215 N  NZ  . LYS A 1 432 ? -20.048 30.106  6.351   1.00 74.06  ?  432 LYS A NZ  1 
ATOM   3216 N  N   . GLU A 1 433 ? -27.247 27.266  6.161   1.00 57.89  ?  433 GLU A N   1 
ATOM   3217 C  CA  . GLU A 1 433 ? -28.379 27.419  5.213   1.00 59.54  ?  433 GLU A CA  1 
ATOM   3218 C  C   . GLU A 1 433 ? -27.833 27.223  3.795   1.00 59.15  ?  433 GLU A C   1 
ATOM   3219 O  O   . GLU A 1 433 ? -26.783 27.821  3.492   1.00 58.90  ?  433 GLU A O   1 
ATOM   3220 C  CB  . GLU A 1 433 ? -28.993 28.804  5.415   1.00 63.56  ?  433 GLU A CB  1 
ATOM   3221 C  CG  . GLU A 1 433 ? -30.339 29.002  4.754   1.00 68.53  ?  433 GLU A CG  1 
ATOM   3222 C  CD  . GLU A 1 433 ? -30.925 30.378  5.021   1.00 70.47  ?  433 GLU A CD  1 
ATOM   3223 O  OE1 . GLU A 1 433 ? -32.121 30.573  4.729   1.00 74.98  ?  433 GLU A OE1 1 
ATOM   3224 O  OE2 . GLU A 1 433 ? -30.181 31.250  5.527   1.00 71.82  -1 433 GLU A OE2 1 
ATOM   3225 N  N   . ILE A 1 434 ? -28.498 26.410  2.969   1.00 59.47  ?  434 ILE A N   1 
ATOM   3226 C  CA  . ILE A 1 434 ? -27.987 25.991  1.625   1.00 62.14  ?  434 ILE A CA  1 
ATOM   3227 C  C   . ILE A 1 434 ? -27.758 27.222  0.736   1.00 64.94  ?  434 ILE A C   1 
ATOM   3228 O  O   . ILE A 1 434 ? -26.911 27.132  -0.170  1.00 67.60  ?  434 ILE A O   1 
ATOM   3229 C  CB  . ILE A 1 434 ? -28.913 24.957  0.953   1.00 62.50  ?  434 ILE A CB  1 
ATOM   3230 C  CG1 . ILE A 1 434 ? -28.269 24.371  -0.305  1.00 64.91  ?  434 ILE A CG1 1 
ATOM   3231 C  CG2 . ILE A 1 434 ? -30.283 25.539  0.653   1.00 64.39  ?  434 ILE A CG2 1 
ATOM   3232 C  CD1 . ILE A 1 434 ? -28.876 23.062  -0.749  1.00 67.77  ?  434 ILE A CD1 1 
ATOM   3233 N  N   . VAL A 1 435 ? -28.477 28.321  0.989   1.00 69.58  ?  435 VAL A N   1 
ATOM   3234 C  CA  . VAL A 1 435 ? -28.402 29.595  0.208   1.00 72.51  ?  435 VAL A CA  1 
ATOM   3235 C  C   . VAL A 1 435 ? -27.029 30.246  0.419   1.00 74.01  ?  435 VAL A C   1 
ATOM   3236 O  O   . VAL A 1 435 ? -26.567 30.943  -0.504  1.00 75.76  ?  435 VAL A O   1 
ATOM   3237 C  CB  . VAL A 1 435 ? -29.551 30.549  0.591   1.00 77.14  ?  435 VAL A CB  1 
ATOM   3238 C  CG1 . VAL A 1 435 ? -29.327 31.965  0.080   1.00 79.63  ?  435 VAL A CG1 1 
ATOM   3239 C  CG2 . VAL A 1 435 ? -30.898 30.023  0.116   1.00 78.14  ?  435 VAL A CG2 1 
ATOM   3240 N  N   . GLN A 1 436 ? -26.405 30.027  1.580   1.00 76.59  ?  436 GLN A N   1 
ATOM   3241 C  CA  . GLN A 1 436 ? -25.088 30.619  1.950   1.00 80.99  ?  436 GLN A CA  1 
ATOM   3242 C  C   . GLN A 1 436 ? -23.970 29.997  1.102   1.00 85.30  ?  436 GLN A C   1 
ATOM   3243 O  O   . GLN A 1 436 ? -22.985 30.705  0.824   1.00 87.82  ?  436 GLN A O   1 
ATOM   3244 C  CB  . GLN A 1 436 ? -24.781 30.392  3.432   1.00 83.67  ?  436 GLN A CB  1 
ATOM   3245 C  CG  . GLN A 1 436 ? -25.810 30.989  4.385   1.00 86.20  ?  436 GLN A CG  1 
ATOM   3246 C  CD  . GLN A 1 436 ? -25.612 32.463  4.643   1.00 86.86  ?  436 GLN A CD  1 
ATOM   3247 O  OE1 . GLN A 1 436 ? -26.527 33.267  4.473   1.00 86.93  ?  436 GLN A OE1 1 
ATOM   3248 N  NE2 . GLN A 1 436 ? -24.415 32.831  5.073   1.00 86.71  ?  436 GLN A NE2 1 
ATOM   3249 N  N   . ASN A 1 437 ? -24.119 28.726  0.710   1.00 92.81  ?  437 ASN A N   1 
ATOM   3250 C  CA  . ASN A 1 437 ? -23.051 27.908  0.066   1.00 95.46  ?  437 ASN A CA  1 
ATOM   3251 C  C   . ASN A 1 437 ? -23.094 28.059  -1.462  1.00 95.61  ?  437 ASN A C   1 
ATOM   3252 O  O   . ASN A 1 437 ? -22.240 27.437  -2.126  1.00 98.23  ?  437 ASN A O   1 
ATOM   3253 C  CB  . ASN A 1 437 ? -23.156 26.429  0.462   1.00 96.96  ?  437 ASN A CB  1 
ATOM   3254 C  CG  . ASN A 1 437 ? -22.851 26.163  1.923   1.00 99.58  ?  437 ASN A CG  1 
ATOM   3255 O  OD1 . ASN A 1 437 ? -21.975 26.795  2.514   1.00 98.29  ?  437 ASN A OD1 1 
ATOM   3256 N  ND2 . ASN A 1 437 ? -23.557 25.212  2.514   1.00 101.25 ?  437 ASN A ND2 1 
ATOM   3257 N  N   . LEU A 1 438 ? -24.032 28.849  -2.000  1.00 95.19  ?  438 LEU A N   1 
ATOM   3258 C  CA  . LEU A 1 438 ? -24.208 29.056  -3.468  1.00 95.18  ?  438 LEU A CA  1 
ATOM   3259 C  C   . LEU A 1 438 ? -22.921 29.622  -4.079  1.00 96.82  ?  438 LEU A C   1 
ATOM   3260 O  O   . LEU A 1 438 ? -22.528 30.740  -3.692  1.00 95.10  ?  438 LEU A O   1 
ATOM   3261 C  CB  . LEU A 1 438 ? -25.376 30.015  -3.729  1.00 93.57  ?  438 LEU A CB  1 
ATOM   3262 C  CG  . LEU A 1 438 ? -26.779 29.416  -3.649  1.00 92.63  ?  438 LEU A CG  1 
ATOM   3263 C  CD1 . LEU A 1 438 ? -27.829 30.502  -3.828  1.00 93.37  ?  438 LEU A CD1 1 
ATOM   3264 C  CD2 . LEU A 1 438 ? -26.973 28.317  -4.683  1.00 90.82  ?  438 LEU A CD2 1 
ATOM   3265 N  N   . ASN A 1 439 ? -22.301 28.869  -4.994  1.00 101.45 ?  439 ASN A N   1 
ATOM   3266 C  CA  . ASN A 1 439 ? -21.239 29.356  -5.918  1.00 106.59 ?  439 ASN A CA  1 
ATOM   3267 C  C   . ASN A 1 439 ? -21.888 29.583  -7.289  1.00 110.57 ?  439 ASN A C   1 
ATOM   3268 O  O   . ASN A 1 439 ? -21.453 28.947  -8.271  1.00 108.89 ?  439 ASN A O   1 
ATOM   3269 C  CB  . ASN A 1 439 ? -20.046 28.397  -5.982  1.00 104.27 ?  439 ASN A CB  1 
ATOM   3270 N  N   . TRP A 1 440 ? -22.906 30.449  -7.329  1.00 116.37 ?  440 TRP A N   1 
ATOM   3271 C  CA  . TRP A 1 440 ? -23.704 30.780  -8.542  1.00 122.98 ?  440 TRP A CA  1 
ATOM   3272 C  C   . TRP A 1 440 ? -22.863 31.648  -9.487  1.00 126.10 ?  440 TRP A C   1 
ATOM   3273 O  O   . TRP A 1 440 ? -22.428 32.737  -9.060  1.00 123.42 ?  440 TRP A O   1 
ATOM   3274 C  CB  . TRP A 1 440 ? -25.021 31.466  -8.152  1.00 128.07 ?  440 TRP A CB  1 
ATOM   3275 C  CG  . TRP A 1 440 ? -25.848 31.915  -9.318  1.00 132.46 ?  440 TRP A CG  1 
ATOM   3276 C  CD1 . TRP A 1 440 ? -26.108 31.211  -10.459 1.00 133.06 ?  440 TRP A CD1 1 
ATOM   3277 C  CD2 . TRP A 1 440 ? -26.542 33.169  -9.455  1.00 135.60 ?  440 TRP A CD2 1 
ATOM   3278 N  NE1 . TRP A 1 440 ? -26.905 31.942  -11.297 1.00 133.92 ?  440 TRP A NE1 1 
ATOM   3279 C  CE2 . TRP A 1 440 ? -27.189 33.147  -10.710 1.00 136.96 ?  440 TRP A CE2 1 
ATOM   3280 C  CE3 . TRP A 1 440 ? -26.679 34.305  -8.647  1.00 135.85 ?  440 TRP A CE3 1 
ATOM   3281 C  CZ2 . TRP A 1 440 ? -27.957 34.217  -11.171 1.00 136.50 ?  440 TRP A CZ2 1 
ATOM   3282 C  CZ3 . TRP A 1 440 ? -27.439 35.361  -9.103  1.00 137.90 ?  440 TRP A CZ3 1 
ATOM   3283 C  CH2 . TRP A 1 440 ? -28.068 35.316  -10.349 1.00 136.46 ?  440 TRP A CH2 1 
ATOM   3284 N  N   . ALA A 1 441 ? -22.651 31.171  -10.719 1.00 130.27 ?  441 ALA A N   1 
ATOM   3285 C  CA  . ALA A 1 441 ? -21.836 31.827  -11.771 1.00 131.99 ?  441 ALA A CA  1 
ATOM   3286 C  C   . ALA A 1 441 ? -22.744 32.312  -12.908 1.00 132.68 ?  441 ALA A C   1 
ATOM   3287 O  O   . ALA A 1 441 ? -22.406 32.061  -14.081 1.00 136.67 ?  441 ALA A O   1 
ATOM   3288 C  CB  . ALA A 1 441 ? -20.779 30.868  -12.269 1.00 130.53 ?  441 ALA A CB  1 
ATOM   3289 N  N   . GLY A 1 442 ? -23.848 32.988  -12.562 1.00 131.42 ?  442 GLY A N   1 
ATOM   3290 C  CA  . GLY A 1 442 ? -24.827 33.549  -13.517 1.00 130.52 ?  442 GLY A CA  1 
ATOM   3291 C  C   . GLY A 1 442 ? -24.882 35.066  -13.443 1.00 131.30 ?  442 GLY A C   1 
ATOM   3292 O  O   . GLY A 1 442 ? -24.113 35.647  -12.650 1.00 127.15 ?  442 GLY A O   1 
ATOM   3293 N  N   . ASN A 1 443 ? -25.762 35.683  -14.239 1.00 134.71 ?  443 ASN A N   1 
ATOM   3294 C  CA  . ASN A 1 443 ? -25.924 37.161  -14.341 1.00 138.60 ?  443 ASN A CA  1 
ATOM   3295 C  C   . ASN A 1 443 ? -27.273 37.560  -13.742 1.00 142.67 ?  443 ASN A C   1 
ATOM   3296 O  O   . ASN A 1 443 ? -28.319 37.166  -14.255 1.00 139.11 ?  443 ASN A O   1 
ATOM   3297 C  CB  . ASN A 1 443 ? -25.779 37.640  -15.790 1.00 137.45 ?  443 ASN A CB  1 
ATOM   3298 C  CG  . ASN A 1 443 ? -25.423 39.108  -15.903 1.00 136.96 ?  443 ASN A CG  1 
ATOM   3299 O  OD1 . ASN A 1 443 ? -25.931 39.938  -15.152 1.00 135.84 ?  443 ASN A OD1 1 
ATOM   3300 N  ND2 . ASN A 1 443 ? -24.556 39.443  -16.845 1.00 136.87 ?  443 ASN A ND2 1 
ATOM   3301 N  N   . PRO A 1 444 ? -27.296 38.349  -12.641 1.00 150.51 ?  444 PRO A N   1 
ATOM   3302 C  CA  . PRO A 1 444 ? -28.553 38.794  -12.034 1.00 152.83 ?  444 PRO A CA  1 
ATOM   3303 C  C   . PRO A 1 444 ? -29.202 39.993  -12.747 1.00 153.55 ?  444 PRO A C   1 
ATOM   3304 O  O   . PRO A 1 444 ? -30.377 40.233  -12.521 1.00 150.14 ?  444 PRO A O   1 
ATOM   3305 C  CB  . PRO A 1 444 ? -28.114 39.176  -10.613 1.00 152.92 ?  444 PRO A CB  1 
ATOM   3306 C  CG  . PRO A 1 444 ? -26.700 39.693  -10.795 1.00 151.16 ?  444 PRO A CG  1 
ATOM   3307 C  CD  . PRO A 1 444 ? -26.117 38.856  -11.917 1.00 150.38 ?  444 PRO A CD  1 
ATOM   3308 N  N   . GLU A 1 445 ? -28.431 40.707  -13.577 1.00 152.58 ?  445 GLU A N   1 
ATOM   3309 C  CA  . GLU A 1 445 ? -28.886 41.888  -14.364 1.00 148.08 ?  445 GLU A CA  1 
ATOM   3310 C  C   . GLU A 1 445 ? -29.709 41.422  -15.574 1.00 143.04 ?  445 GLU A C   1 
ATOM   3311 O  O   . GLU A 1 445 ? -30.616 42.172  -15.990 1.00 140.84 ?  445 GLU A O   1 
ATOM   3312 C  CB  . GLU A 1 445 ? -27.684 42.722  -14.814 1.00 146.25 ?  445 GLU A CB  1 
ATOM   3313 N  N   . LYS A 1 446 ? -29.393 40.237  -16.113 1.00 137.25 ?  446 LYS A N   1 
ATOM   3314 C  CA  . LYS A 1 446 ? -30.054 39.625  -17.301 1.00 131.62 ?  446 LYS A CA  1 
ATOM   3315 C  C   . LYS A 1 446 ? -31.563 39.500  -17.046 1.00 128.49 ?  446 LYS A C   1 
ATOM   3316 O  O   . LYS A 1 446 ? -31.948 38.770  -16.107 1.00 128.71 ?  446 LYS A O   1 
ATOM   3317 C  CB  . LYS A 1 446 ? -29.424 38.261  -17.610 1.00 130.33 ?  446 LYS A CB  1 
ATOM   3318 C  CG  . LYS A 1 446 ? -29.978 37.529  -18.828 1.00 127.47 ?  446 LYS A CG  1 
ATOM   3319 C  CD  . LYS A 1 446 ? -29.637 38.177  -20.157 1.00 123.66 ?  446 LYS A CD  1 
ATOM   3320 C  CE  . LYS A 1 446 ? -30.165 37.401  -21.346 1.00 120.71 ?  446 LYS A CE  1 
ATOM   3321 N  NZ  . LYS A 1 446 ? -31.644 37.298  -21.331 1.00 118.23 ?  446 LYS A NZ  1 
ATOM   3322 N  N   . SER A 1 447 ? -32.368 40.200  -17.854 1.00 122.66 ?  447 SER A N   1 
ATOM   3323 C  CA  . SER A 1 447 ? -33.858 40.142  -17.859 1.00 116.27 ?  447 SER A CA  1 
ATOM   3324 C  C   . SER A 1 447 ? -34.334 39.301  -19.051 1.00 111.56 ?  447 SER A C   1 
ATOM   3325 O  O   . SER A 1 447 ? -33.573 39.185  -20.034 1.00 106.45 ?  447 SER A O   1 
ATOM   3326 C  CB  . SER A 1 447 ? -34.459 41.524  -17.886 1.00 113.47 ?  447 SER A CB  1 
ATOM   3327 N  N   . TYR A 1 448 ? -35.545 38.739  -18.956 1.00 109.58 ?  448 TYR A N   1 
ATOM   3328 C  CA  . TYR A 1 448 ? -36.141 37.805  -19.951 1.00 108.19 ?  448 TYR A CA  1 
ATOM   3329 C  C   . TYR A 1 448 ? -37.493 38.339  -20.441 1.00 111.27 ?  448 TYR A C   1 
ATOM   3330 O  O   . TYR A 1 448 ? -38.324 38.747  -19.601 1.00 108.09 ?  448 TYR A O   1 
ATOM   3331 C  CB  . TYR A 1 448 ? -36.303 36.407  -19.344 1.00 104.92 ?  448 TYR A CB  1 
ATOM   3332 C  CG  . TYR A 1 448 ? -35.011 35.731  -18.962 1.00 102.47 ?  448 TYR A CG  1 
ATOM   3333 C  CD1 . TYR A 1 448 ? -34.311 34.956  -19.874 1.00 99.96  ?  448 TYR A CD1 1 
ATOM   3334 C  CD2 . TYR A 1 448 ? -34.480 35.867  -17.688 1.00 100.65 ?  448 TYR A CD2 1 
ATOM   3335 C  CE1 . TYR A 1 448 ? -33.120 34.335  -19.532 1.00 99.18  ?  448 TYR A CE1 1 
ATOM   3336 C  CE2 . TYR A 1 448 ? -33.291 35.253  -17.329 1.00 98.56  ?  448 TYR A CE2 1 
ATOM   3337 C  CZ  . TYR A 1 448 ? -32.608 34.482  -18.254 1.00 98.23  ?  448 TYR A CZ  1 
ATOM   3338 O  OH  . TYR A 1 448 ? -31.435 33.874  -17.906 1.00 90.35  ?  448 TYR A OH  1 
ATOM   3339 N  N   . GLU A 1 449 ? -37.699 38.331  -21.764 1.00 113.27 ?  449 GLU A N   1 
ATOM   3340 C  CA  . GLU A 1 449 ? -39.006 38.618  -22.418 1.00 110.96 ?  449 GLU A CA  1 
ATOM   3341 C  C   . GLU A 1 449 ? -39.996 37.514  -22.031 1.00 105.34 ?  449 GLU A C   1 
ATOM   3342 O  O   . GLU A 1 449 ? -39.621 36.332  -22.140 1.00 103.89 ?  449 GLU A O   1 
ATOM   3343 C  CB  . GLU A 1 449 ? -38.854 38.694  -23.940 1.00 115.85 ?  449 GLU A CB  1 
ATOM   3344 C  CG  . GLU A 1 449 ? -38.046 39.890  -24.417 1.00 120.88 ?  449 GLU A CG  1 
ATOM   3345 C  CD  . GLU A 1 449 ? -38.784 41.220  -24.428 1.00 125.14 ?  449 GLU A CD  1 
ATOM   3346 O  OE1 . GLU A 1 449 ? -38.223 42.196  -24.965 1.00 127.26 ?  449 GLU A OE1 1 
ATOM   3347 O  OE2 . GLU A 1 449 ? -39.916 41.281  -23.904 1.00 127.47 ?  449 GLU A OE2 1 
ATOM   3348 N  N   . THR A 1 450 ? -41.199 37.891  -21.584 1.00 100.56 ?  450 THR A N   1 
ATOM   3349 C  CA  . THR A 1 450 ? -42.243 36.944  -21.094 1.00 96.92  ?  450 THR A CA  1 
ATOM   3350 C  C   . THR A 1 450 ? -43.397 36.867  -22.098 1.00 94.63  ?  450 THR A C   1 
ATOM   3351 O  O   . THR A 1 450 ? -43.490 37.760  -22.959 1.00 92.61  ?  450 THR A O   1 
ATOM   3352 C  CB  . THR A 1 450 ? -42.748 37.354  -19.704 1.00 97.19  ?  450 THR A CB  1 
ATOM   3353 O  OG1 . THR A 1 450 ? -43.697 38.411  -19.855 1.00 94.95  ?  450 THR A OG1 1 
ATOM   3354 C  CG2 . THR A 1 450 ? -41.627 37.785  -18.783 1.00 97.73  ?  450 THR A CG2 1 
ATOM   3355 N  N   . GLY A 1 451 ? -44.240 35.838  -21.967 1.00 97.55  ?  451 GLY A N   1 
ATOM   3356 C  CA  . GLY A 1 451 ? -45.411 35.588  -22.832 1.00 97.19  ?  451 GLY A CA  1 
ATOM   3357 C  C   . GLY A 1 451 ? -46.729 35.753  -22.077 1.00 97.99  ?  451 GLY A C   1 
ATOM   3358 O  O   . GLY A 1 451 ? -46.764 36.357  -21.006 1.00 92.44  ?  451 GLY A O   1 
ATOM   3359 N  N   . PRO A 1 452 ? -47.848 35.220  -22.624 1.00 100.37 ?  452 PRO A N   1 
ATOM   3360 C  CA  . PRO A 1 452 ? -49.164 35.308  -21.986 1.00 101.47 ?  452 PRO A CA  1 
ATOM   3361 C  C   . PRO A 1 452 ? -49.222 35.031  -20.475 1.00 103.77 ?  452 PRO A C   1 
ATOM   3362 O  O   . PRO A 1 452 ? -49.919 35.754  -19.788 1.00 107.80 ?  452 PRO A O   1 
ATOM   3363 C  CB  . PRO A 1 452 ? -49.960 34.209  -22.708 1.00 101.38 ?  452 PRO A CB  1 
ATOM   3364 C  CG  . PRO A 1 452 ? -49.371 34.181  -24.101 1.00 100.97 ?  452 PRO A CG  1 
ATOM   3365 C  CD  . PRO A 1 452 ? -47.903 34.506  -23.912 1.00 101.19 ?  452 PRO A CD  1 
ATOM   3366 N  N   . MET A 1 453 ? -48.508 34.004  -20.001 1.00 104.09 ?  453 MET A N   1 
ATOM   3367 C  CA  . MET A 1 453 ? -48.671 33.450  -18.627 1.00 104.50 ?  453 MET A CA  1 
ATOM   3368 C  C   . MET A 1 453 ? -47.623 34.024  -17.662 1.00 102.12 ?  453 MET A C   1 
ATOM   3369 O  O   . MET A 1 453 ? -47.516 33.498  -16.536 1.00 103.78 ?  453 MET A O   1 
ATOM   3370 C  CB  . MET A 1 453 ? -48.601 31.922  -18.657 1.00 104.80 ?  453 MET A CB  1 
ATOM   3371 C  CG  . MET A 1 453 ? -49.873 31.306  -19.199 1.00 108.27 ?  453 MET A CG  1 
ATOM   3372 S  SD  . MET A 1 453 ? -49.706 29.558  -19.611 1.00 118.41 ?  453 MET A SD  1 
ATOM   3373 C  CE  . MET A 1 453 ? -48.682 29.653  -21.078 1.00 115.94 ?  453 MET A CE  1 
ATOM   3374 N  N   . GLY A 1 454 ? -46.904 35.078  -18.067 1.00 97.81  ?  454 GLY A N   1 
ATOM   3375 C  CA  . GLY A 1 454 ? -46.140 35.952  -17.153 1.00 95.05  ?  454 GLY A CA  1 
ATOM   3376 C  C   . GLY A 1 454 ? -44.701 35.502  -16.962 1.00 92.16  ?  454 GLY A C   1 
ATOM   3377 O  O   . GLY A 1 454 ? -44.238 34.633  -17.731 1.00 91.67  ?  454 GLY A O   1 
ATOM   3378 N  N   . ASP A 1 455 ? -44.031 36.069  -15.952 1.00 89.90  ?  455 ASP A N   1 
ATOM   3379 C  CA  . ASP A 1 455 ? -42.563 35.951  -15.726 1.00 88.69  ?  455 ASP A CA  1 
ATOM   3380 C  C   . ASP A 1 455 ? -42.244 34.699  -14.893 1.00 85.36  ?  455 ASP A C   1 
ATOM   3381 O  O   . ASP A 1 455 ? -41.052 34.509  -14.577 1.00 84.62  ?  455 ASP A O   1 
ATOM   3382 C  CB  . ASP A 1 455 ? -41.988 37.228  -15.097 1.00 89.85  ?  455 ASP A CB  1 
ATOM   3383 C  CG  . ASP A 1 455 ? -42.448 37.529  -13.678 1.00 92.47  ?  455 ASP A CG  1 
ATOM   3384 O  OD1 . ASP A 1 455 ? -43.553 37.082  -13.305 1.00 91.24  ?  455 ASP A OD1 1 
ATOM   3385 O  OD2 . ASP A 1 455 ? -41.696 38.220  -12.956 1.00 94.58  -1 455 ASP A OD2 1 
ATOM   3386 N  N   . ARG A 1 456 ? -43.249 33.877  -14.559 1.00 79.78  ?  456 ARG A N   1 
ATOM   3387 C  CA  . ARG A 1 456 ? -43.049 32.574  -13.863 1.00 77.29  ?  456 ARG A CA  1 
ATOM   3388 C  C   . ARG A 1 456 ? -42.184 31.654  -14.733 1.00 78.49  ?  456 ARG A C   1 
ATOM   3389 O  O   . ARG A 1 456 ? -41.345 30.924  -14.166 1.00 83.18  ?  456 ARG A O   1 
ATOM   3390 C  CB  . ARG A 1 456 ? -44.386 31.894  -13.556 1.00 74.66  ?  456 ARG A CB  1 
ATOM   3391 C  CG  . ARG A 1 456 ? -44.264 30.451  -13.084 1.00 73.24  ?  456 ARG A CG  1 
ATOM   3392 C  CD  . ARG A 1 456 ? -43.448 30.317  -11.812 1.00 73.53  ?  456 ARG A CD  1 
ATOM   3393 N  NE  . ARG A 1 456 ? -43.325 28.932  -11.368 1.00 73.78  ?  456 ARG A NE  1 
ATOM   3394 C  CZ  . ARG A 1 456 ? -42.347 28.092  -11.709 1.00 74.17  ?  456 ARG A CZ  1 
ATOM   3395 N  NH1 . ARG A 1 456 ? -41.373 28.472  -12.520 1.00 75.44  ?  456 ARG A NH1 1 
ATOM   3396 N  NH2 . ARG A 1 456 ? -42.350 26.858  -11.233 1.00 73.69  ?  456 ARG A NH2 1 
ATOM   3397 N  N   . LEU A 1 457 ? -42.384 31.686  -16.053 1.00 74.83  ?  457 LEU A N   1 
ATOM   3398 C  CA  . LEU A 1 457 ? -41.658 30.826  -17.026 1.00 72.37  ?  457 LEU A CA  1 
ATOM   3399 C  C   . LEU A 1 457 ? -40.371 31.530  -17.473 1.00 72.40  ?  457 LEU A C   1 
ATOM   3400 O  O   . LEU A 1 457 ? -40.151 31.647  -18.695 1.00 71.80  ?  457 LEU A O   1 
ATOM   3401 C  CB  . LEU A 1 457 ? -42.580 30.519  -18.211 1.00 71.02  ?  457 LEU A CB  1 
ATOM   3402 C  CG  . LEU A 1 457 ? -43.952 29.947  -17.855 1.00 71.75  ?  457 LEU A CG  1 
ATOM   3403 C  CD1 . LEU A 1 457 ? -44.731 29.596  -19.113 1.00 72.37  ?  457 LEU A CD1 1 
ATOM   3404 C  CD2 . LEU A 1 457 ? -43.830 28.726  -16.956 1.00 72.95  ?  457 LEU A CD2 1 
ATOM   3405 N  N   . THR A 1 458 ? -39.553 31.979  -16.514 1.00 74.06  ?  458 THR A N   1 
ATOM   3406 C  CA  . THR A 1 458 ? -38.179 32.506  -16.752 1.00 78.72  ?  458 THR A CA  1 
ATOM   3407 C  C   . THR A 1 458 ? -37.225 31.877  -15.739 1.00 78.99  ?  458 THR A C   1 
ATOM   3408 O  O   . THR A 1 458 ? -37.593 31.687  -14.582 1.00 81.55  ?  458 THR A O   1 
ATOM   3409 C  CB  . THR A 1 458 ? -38.134 34.040  -16.690 1.00 82.50  ?  458 THR A CB  1 
ATOM   3410 O  OG1 . THR A 1 458 ? -38.319 34.465  -15.338 1.00 81.47  ?  458 THR A OG1 1 
ATOM   3411 C  CG2 . THR A 1 458 ? -39.172 34.693  -17.579 1.00 83.15  ?  458 THR A CG2 1 
ATOM   3412 N  N   . PRO A 1 459 ? -35.978 31.528  -16.131 1.00 76.66  ?  459 PRO A N   1 
ATOM   3413 C  CA  . PRO A 1 459 ? -34.984 31.028  -15.179 1.00 76.59  ?  459 PRO A CA  1 
ATOM   3414 C  C   . PRO A 1 459 ? -34.795 31.905  -13.929 1.00 75.49  ?  459 PRO A C   1 
ATOM   3415 O  O   . PRO A 1 459 ? -34.463 31.363  -12.893 1.00 75.88  ?  459 PRO A O   1 
ATOM   3416 C  CB  . PRO A 1 459 ? -33.692 31.000  -16.010 1.00 77.76  ?  459 PRO A CB  1 
ATOM   3417 C  CG  . PRO A 1 459 ? -34.174 30.786  -17.428 1.00 77.55  ?  459 PRO A CG  1 
ATOM   3418 C  CD  . PRO A 1 459 ? -35.462 31.578  -17.509 1.00 76.89  ?  459 PRO A CD  1 
ATOM   3419 N  N   . ARG A 1 460 ? -34.999 33.220  -14.059 1.00 77.90  ?  460 ARG A N   1 
ATOM   3420 C  CA  . ARG A 1 460 ? -34.852 34.203  -12.942 1.00 80.26  ?  460 ARG A CA  1 
ATOM   3421 C  C   . ARG A 1 460 ? -35.915 33.940  -11.864 1.00 74.83  ?  460 ARG A C   1 
ATOM   3422 O  O   . ARG A 1 460 ? -35.545 33.913  -10.671 1.00 72.78  ?  460 ARG A O   1 
ATOM   3423 C  CB  . ARG A 1 460 ? -34.926 35.637  -13.479 1.00 87.49  ?  460 ARG A CB  1 
ATOM   3424 C  CG  . ARG A 1 460 ? -34.798 36.723  -12.419 1.00 95.56  ?  460 ARG A CG  1 
ATOM   3425 C  CD  . ARG A 1 460 ? -34.564 38.101  -13.018 1.00 102.58 ?  460 ARG A CD  1 
ATOM   3426 N  NE  . ARG A 1 460 ? -34.985 39.182  -12.130 1.00 109.28 ?  460 ARG A NE  1 
ATOM   3427 C  CZ  . ARG A 1 460 ? -36.249 39.546  -11.903 1.00 115.17 ?  460 ARG A CZ  1 
ATOM   3428 N  NH1 . ARG A 1 460 ? -37.254 38.915  -12.490 1.00 117.12 ?  460 ARG A NH1 1 
ATOM   3429 N  NH2 . ARG A 1 460 ? -36.507 40.546  -11.075 1.00 115.73 ?  460 ARG A NH2 1 
ATOM   3430 N  N   . LYS A 1 461 ? -37.177 33.752  -12.265 1.00 70.33  ?  461 LYS A N   1 
ATOM   3431 C  CA  . LYS A 1 461 ? -38.317 33.504  -11.336 1.00 70.27  ?  461 LYS A CA  1 
ATOM   3432 C  C   . LYS A 1 461 ? -38.234 32.072  -10.793 1.00 67.99  ?  461 LYS A C   1 
ATOM   3433 O  O   . LYS A 1 461 ? -38.507 31.888  -9.593  1.00 71.55  ?  461 LYS A O   1 
ATOM   3434 C  CB  . LYS A 1 461 ? -39.663 33.748  -12.026 1.00 70.14  ?  461 LYS A CB  1 
ATOM   3435 N  N   . SER A 1 462 ? -37.888 31.099  -11.642 1.00 65.72  ?  462 SER A N   1 
ATOM   3436 C  CA  . SER A 1 462 ? -37.649 29.685  -11.233 1.00 65.10  ?  462 SER A CA  1 
ATOM   3437 C  C   . SER A 1 462 ? -36.637 29.654  -10.078 1.00 63.83  ?  462 SER A C   1 
ATOM   3438 O  O   . SER A 1 462 ? -36.966 29.091  -9.015  1.00 64.40  ?  462 SER A O   1 
ATOM   3439 C  CB  . SER A 1 462 ? -37.193 28.825  -12.392 1.00 62.88  ?  462 SER A CB  1 
ATOM   3440 O  OG  . SER A 1 462 ? -38.298 28.366  -13.162 1.00 57.98  ?  462 SER A OG  1 
ATOM   3441 N  N   . PHE A 1 463 ? -35.466 30.263  -10.279 1.00 63.40  ?  463 PHE A N   1 
ATOM   3442 C  CA  . PHE A 1 463 ? -34.356 30.314  -9.289  1.00 64.39  ?  463 PHE A CA  1 
ATOM   3443 C  C   . PHE A 1 463 ? -34.833 31.015  -8.008  1.00 66.80  ?  463 PHE A C   1 
ATOM   3444 O  O   . PHE A 1 463 ? -34.531 30.515  -6.903  1.00 68.91  ?  463 PHE A O   1 
ATOM   3445 C  CB  . PHE A 1 463 ? -33.121 30.986  -9.899  1.00 63.01  ?  463 PHE A CB  1 
ATOM   3446 C  CG  . PHE A 1 463 ? -31.869 30.922  -9.058  1.00 62.31  ?  463 PHE A CG  1 
ATOM   3447 C  CD1 . PHE A 1 463 ? -31.578 29.810  -8.278  1.00 61.84  ?  463 PHE A CD1 1 
ATOM   3448 C  CD2 . PHE A 1 463 ? -30.961 31.967  -9.070  1.00 62.15  ?  463 PHE A CD2 1 
ATOM   3449 C  CE1 . PHE A 1 463 ? -30.424 29.759  -7.513  1.00 61.65  ?  463 PHE A CE1 1 
ATOM   3450 C  CE2 . PHE A 1 463 ? -29.803 31.910  -8.309  1.00 63.94  ?  463 PHE A CE2 1 
ATOM   3451 C  CZ  . PHE A 1 463 ? -29.536 30.807  -7.532  1.00 62.00  ?  463 PHE A CZ  1 
ATOM   3452 N  N   . ALA A 1 464 ? -35.567 32.124  -8.149  1.00 66.53  ?  464 ALA A N   1 
ATOM   3453 C  CA  . ALA A 1 464 ? -36.165 32.892  -7.027  1.00 64.63  ?  464 ALA A CA  1 
ATOM   3454 C  C   . ALA A 1 464 ? -37.125 32.000  -6.226  1.00 62.90  ?  464 ALA A C   1 
ATOM   3455 O  O   . ALA A 1 464 ? -37.091 32.066  -4.983  1.00 64.53  ?  464 ALA A O   1 
ATOM   3456 C  CB  . ALA A 1 464 ? -36.870 34.118  -7.552  1.00 66.19  ?  464 ALA A CB  1 
ATOM   3457 N  N   . ILE A 1 465 ? -37.949 31.200  -6.911  1.00 60.86  ?  465 ILE A N   1 
ATOM   3458 C  CA  . ILE A 1 465 ? -38.953 30.288  -6.278  1.00 61.75  ?  465 ILE A CA  1 
ATOM   3459 C  C   . ILE A 1 465 ? -38.221 29.179  -5.511  1.00 63.13  ?  465 ILE A C   1 
ATOM   3460 O  O   . ILE A 1 465 ? -38.661 28.859  -4.384  1.00 63.84  ?  465 ILE A O   1 
ATOM   3461 C  CB  . ILE A 1 465 ? -39.934 29.724  -7.326  1.00 61.20  ?  465 ILE A CB  1 
ATOM   3462 C  CG1 . ILE A 1 465 ? -40.919 30.798  -7.796  1.00 61.21  ?  465 ILE A CG1 1 
ATOM   3463 C  CG2 . ILE A 1 465 ? -40.659 28.491  -6.797  1.00 60.33  ?  465 ILE A CG2 1 
ATOM   3464 C  CD1 . ILE A 1 465 ? -41.568 30.498  -9.126  1.00 61.97  ?  465 ILE A CD1 1 
ATOM   3465 N  N   . TRP A 1 466 ? -37.161 28.607  -6.095  1.00 62.36  ?  466 TRP A N   1 
ATOM   3466 C  CA  . TRP A 1 466 ? -36.312 27.583  -5.429  1.00 60.82  ?  466 TRP A CA  1 
ATOM   3467 C  C   . TRP A 1 466 ? -35.717 28.161  -4.139  1.00 60.78  ?  466 TRP A C   1 
ATOM   3468 O  O   . TRP A 1 466 ? -35.821 27.477  -3.105  1.00 60.29  ?  466 TRP A O   1 
ATOM   3469 C  CB  . TRP A 1 466 ? -35.205 27.051  -6.346  1.00 59.61  ?  466 TRP A CB  1 
ATOM   3470 C  CG  . TRP A 1 466 ? -34.277 26.129  -5.614  1.00 58.73  ?  466 TRP A CG  1 
ATOM   3471 C  CD1 . TRP A 1 466 ? -34.463 24.799  -5.366  1.00 58.09  ?  466 TRP A CD1 1 
ATOM   3472 C  CD2 . TRP A 1 466 ? -33.044 26.485  -4.965  1.00 57.26  ?  466 TRP A CD2 1 
ATOM   3473 N  NE1 . TRP A 1 466 ? -33.421 24.299  -4.634  1.00 55.62  ?  466 TRP A NE1 1 
ATOM   3474 C  CE2 . TRP A 1 466 ? -32.534 25.310  -4.372  1.00 55.30  ?  466 TRP A CE2 1 
ATOM   3475 C  CE3 . TRP A 1 466 ? -32.312 27.672  -4.845  1.00 58.51  ?  466 TRP A CE3 1 
ATOM   3476 C  CZ2 . TRP A 1 466 ? -31.328 25.291  -3.674  1.00 55.79  ?  466 TRP A CZ2 1 
ATOM   3477 C  CZ3 . TRP A 1 466 ? -31.123 27.654  -4.149  1.00 59.15  ?  466 TRP A CZ3 1 
ATOM   3478 C  CH2 . TRP A 1 466 ? -30.637 26.477  -3.576  1.00 57.96  ?  466 TRP A CH2 1 
ATOM   3479 N  N   . LYS A 1 467 ? -35.103 29.350  -4.214  1.00 62.06  ?  467 LYS A N   1 
ATOM   3480 C  CA  . LYS A 1 467 ? -34.448 30.054  -3.072  1.00 66.42  ?  467 LYS A CA  1 
ATOM   3481 C  C   . LYS A 1 467 ? -35.429 30.203  -1.903  1.00 68.20  ?  467 LYS A C   1 
ATOM   3482 O  O   . LYS A 1 467 ? -35.007 30.015  -0.743  1.00 68.63  ?  467 LYS A O   1 
ATOM   3483 C  CB  . LYS A 1 467 ? -33.962 31.448  -3.478  1.00 70.26  ?  467 LYS A CB  1 
ATOM   3484 C  CG  . LYS A 1 467 ? -32.586 31.509  -4.122  1.00 74.84  ?  467 LYS A CG  1 
ATOM   3485 C  CD  . LYS A 1 467 ? -32.108 32.932  -4.325  1.00 81.12  ?  467 LYS A CD  1 
ATOM   3486 C  CE  . LYS A 1 467 ? -30.744 33.018  -4.973  1.00 86.93  ?  467 LYS A CE  1 
ATOM   3487 N  NZ  . LYS A 1 467 ? -30.192 34.392  -4.907  1.00 89.76  ?  467 LYS A NZ  1 
ATOM   3488 N  N   . GLU A 1 468 ? -36.678 30.562  -2.205  1.00 72.01  ?  468 GLU A N   1 
ATOM   3489 C  CA  . GLU A 1 468 ? -37.771 30.721  -1.210  1.00 75.66  ?  468 GLU A CA  1 
ATOM   3490 C  C   . GLU A 1 468 ? -38.054 29.358  -0.562  1.00 73.39  ?  468 GLU A C   1 
ATOM   3491 O  O   . GLU A 1 468 ? -38.238 29.321  0.672   1.00 76.60  ?  468 GLU A O   1 
ATOM   3492 C  CB  . GLU A 1 468 ? -39.001 31.326  -1.895  1.00 83.69  ?  468 GLU A CB  1 
ATOM   3493 C  CG  . GLU A 1 468 ? -40.191 31.552  -0.974  1.00 92.48  ?  468 GLU A CG  1 
ATOM   3494 C  CD  . GLU A 1 468 ? -39.953 32.478  0.209   1.00 98.51  ?  468 GLU A CD  1 
ATOM   3495 O  OE1 . GLU A 1 468 ? -39.015 33.304  0.142   1.00 98.92  ?  468 GLU A OE1 1 
ATOM   3496 O  OE2 . GLU A 1 468 ? -40.710 32.370  1.197   1.00 105.34 -1 468 GLU A OE2 1 
ATOM   3497 N  N   . SER A 1 469 ? -38.053 28.284  -1.361  1.00 67.13  ?  469 SER A N   1 
ATOM   3498 C  CA  . SER A 1 469 ? -38.457 26.910  -0.952  1.00 62.45  ?  469 SER A CA  1 
ATOM   3499 C  C   . SER A 1 469 ? -37.425 26.266  -0.019  1.00 60.85  ?  469 SER A C   1 
ATOM   3500 O  O   . SER A 1 469 ? -37.817 25.311  0.685   1.00 61.61  ?  469 SER A O   1 
ATOM   3501 C  CB  . SER A 1 469 ? -38.706 26.028  -2.153  1.00 62.96  ?  469 SER A CB  1 
ATOM   3502 O  OG  . SER A 1 469 ? -37.488 25.527  -2.687  1.00 61.86  ?  469 SER A OG  1 
ATOM   3503 N  N   . VAL A 1 470 ? -36.169 26.735  -0.029  1.00 57.99  ?  470 VAL A N   1 
ATOM   3504 C  CA  . VAL A 1 470 ? -35.048 26.134  0.764   1.00 56.33  ?  470 VAL A CA  1 
ATOM   3505 C  C   . VAL A 1 470 ? -34.568 27.138  1.816   1.00 57.07  ?  470 VAL A C   1 
ATOM   3506 O  O   . VAL A 1 470 ? -33.440 26.965  2.318   1.00 62.04  ?  470 VAL A O   1 
ATOM   3507 C  CB  . VAL A 1 470 ? -33.882 25.657  -0.128  1.00 53.97  ?  470 VAL A CB  1 
ATOM   3508 C  CG1 . VAL A 1 470 ? -34.306 24.527  -1.048  1.00 54.30  ?  470 VAL A CG1 1 
ATOM   3509 C  CG2 . VAL A 1 470 ? -33.249 26.788  -0.925  1.00 54.12  ?  470 VAL A CG2 1 
ATOM   3510 N  N   . ARG A 1 471 ? -35.385 28.145  2.138   1.00 58.48  ?  471 ARG A N   1 
ATOM   3511 C  CA  . ARG A 1 471 ? -35.067 29.142  3.199   1.00 56.34  ?  471 ARG A CA  1 
ATOM   3512 C  C   . ARG A 1 471 ? -35.014 28.403  4.547   1.00 55.52  ?  471 ARG A C   1 
ATOM   3513 O  O   . ARG A 1 471 ? -35.915 27.585  4.812   1.00 55.59  ?  471 ARG A O   1 
ATOM   3514 C  CB  . ARG A 1 471 ? -36.085 30.289  3.179   1.00 53.97  ?  471 ARG A CB  1 
ATOM   3515 N  N   . LEU A 1 472 ? -33.959 28.644  5.330   1.00 56.19  ?  472 LEU A N   1 
ATOM   3516 C  CA  . LEU A 1 472 ? -33.741 28.093  6.700   1.00 58.85  ?  472 LEU A CA  1 
ATOM   3517 C  C   . LEU A 1 472 ? -33.425 26.591  6.640   1.00 57.94  ?  472 LEU A C   1 
ATOM   3518 O  O   . LEU A 1 472 ? -33.511 25.924  7.698   1.00 57.08  ?  472 LEU A O   1 
ATOM   3519 C  CB  . LEU A 1 472 ? -34.979 28.356  7.568   1.00 61.03  ?  472 LEU A CB  1 
ATOM   3520 C  CG  . LEU A 1 472 ? -35.513 29.789  7.582   1.00 61.28  ?  472 LEU A CG  1 
ATOM   3521 C  CD1 . LEU A 1 472 ? -36.669 29.912  8.562   1.00 63.02  ?  472 LEU A CD1 1 
ATOM   3522 C  CD2 . LEU A 1 472 ? -34.419 30.789  7.926   1.00 60.60  ?  472 LEU A CD2 1 
ATOM   3523 N  N   . GLN A 1 473 ? -33.047 26.084  5.464   1.00 58.89  ?  473 GLN A N   1 
ATOM   3524 C  CA  . GLN A 1 473 ? -32.696 24.655  5.251   1.00 60.50  ?  473 GLN A CA  1 
ATOM   3525 C  C   . GLN A 1 473 ? -31.246 24.540  4.775   1.00 59.83  ?  473 GLN A C   1 
ATOM   3526 O  O   . GLN A 1 473 ? -30.777 25.452  4.064   1.00 59.90  ?  473 GLN A O   1 
ATOM   3527 C  CB  . GLN A 1 473 ? -33.615 24.008  4.220   1.00 62.95  ?  473 GLN A CB  1 
ATOM   3528 C  CG  . GLN A 1 473 ? -35.050 23.853  4.692   1.00 63.85  ?  473 GLN A CG  1 
ATOM   3529 C  CD  . GLN A 1 473 ? -35.890 23.178  3.638   1.00 64.36  ?  473 GLN A CD  1 
ATOM   3530 O  OE1 . GLN A 1 473 ? -35.383 22.460  2.778   1.00 64.54  ?  473 GLN A OE1 1 
ATOM   3531 N  NE2 . GLN A 1 473 ? -37.190 23.411  3.692   1.00 66.74  ?  473 GLN A NE2 1 
ATOM   3532 N  N   . ALA A 1 474 ? -30.591 23.437  5.148   1.00 59.12  ?  474 ALA A N   1 
ATOM   3533 C  CA  . ALA A 1 474 ? -29.211 23.073  4.753   1.00 57.79  ?  474 ALA A CA  1 
ATOM   3534 C  C   . ALA A 1 474 ? -29.266 21.946  3.720   1.00 58.00  ?  474 ALA A C   1 
ATOM   3535 O  O   . ALA A 1 474 ? -30.345 21.349  3.554   1.00 56.35  ?  474 ALA A O   1 
ATOM   3536 C  CB  . ALA A 1 474 ? -28.424 22.658  5.970   1.00 57.36  ?  474 ALA A CB  1 
ATOM   3537 N  N   . GLN A 1 475 ? -28.141 21.688  3.049   1.00 61.15  ?  475 GLN A N   1 
ATOM   3538 C  CA  . GLN A 1 475 ? -27.920 20.486  2.200   1.00 62.31  ?  475 GLN A CA  1 
ATOM   3539 C  C   . GLN A 1 475 ? -28.345 19.255  2.999   1.00 60.00  ?  475 GLN A C   1 
ATOM   3540 O  O   . GLN A 1 475 ? -27.789 18.992  4.063   1.00 61.54  ?  475 GLN A O   1 
ATOM   3541 C  CB  . GLN A 1 475 ? -26.447 20.421  1.787   1.00 68.30  ?  475 GLN A CB  1 
ATOM   3542 C  CG  . GLN A 1 475 ? -26.093 19.231  0.907   1.00 74.83  ?  475 GLN A CG  1 
ATOM   3543 C  CD  . GLN A 1 475 ? -26.647 19.367  -0.489  1.00 80.87  ?  475 GLN A CD  1 
ATOM   3544 O  OE1 . GLN A 1 475 ? -26.553 20.422  -1.111  1.00 89.12  ?  475 GLN A OE1 1 
ATOM   3545 N  NE2 . GLN A 1 475 ? -27.221 18.290  -1.002  1.00 84.11  ?  475 GLN A NE2 1 
ATOM   3546 N  N   . PRO A 1 476 ? -29.343 18.467  2.533   1.00 58.37  ?  476 PRO A N   1 
ATOM   3547 C  CA  . PRO A 1 476 ? -29.741 17.239  3.225   1.00 58.23  ?  476 PRO A CA  1 
ATOM   3548 C  C   . PRO A 1 476 ? -28.572 16.276  3.486   1.00 57.61  ?  476 PRO A C   1 
ATOM   3549 O  O   . PRO A 1 476 ? -27.674 16.187  2.663   1.00 57.31  ?  476 PRO A O   1 
ATOM   3550 C  CB  . PRO A 1 476 ? -30.744 16.577  2.269   1.00 57.67  ?  476 PRO A CB  1 
ATOM   3551 C  CG  . PRO A 1 476 ? -31.295 17.727  1.454   1.00 58.39  ?  476 PRO A CG  1 
ATOM   3552 C  CD  . PRO A 1 476 ? -30.148 18.710  1.328   1.00 58.77  ?  476 PRO A CD  1 
ATOM   3553 N  N   . TRP A 1 477 ? -28.612 15.586  4.626   1.00 56.01  ?  477 TRP A N   1 
ATOM   3554 C  CA  . TRP A 1 477 ? -27.637 14.522  4.982   1.00 55.43  ?  477 TRP A CA  1 
ATOM   3555 C  C   . TRP A 1 477 ? -27.882 13.321  4.065   1.00 56.05  ?  477 TRP A C   1 
ATOM   3556 O  O   . TRP A 1 477 ? -28.988 12.754  4.123   1.00 54.06  ?  477 TRP A O   1 
ATOM   3557 C  CB  . TRP A 1 477 ? -27.746 14.144  6.464   1.00 54.90  ?  477 TRP A CB  1 
ATOM   3558 C  CG  . TRP A 1 477 ? -27.614 15.313  7.388   1.00 54.08  ?  477 TRP A CG  1 
ATOM   3559 C  CD1 . TRP A 1 477 ? -28.626 15.989  8.005   1.00 55.36  ?  477 TRP A CD1 1 
ATOM   3560 C  CD2 . TRP A 1 477 ? -26.395 15.968  7.783   1.00 52.58  ?  477 TRP A CD2 1 
ATOM   3561 N  NE1 . TRP A 1 477 ? -28.121 17.011  8.763   1.00 55.66  ?  477 TRP A NE1 1 
ATOM   3562 C  CE2 . TRP A 1 477 ? -26.756 17.026  8.645   1.00 53.06  ?  477 TRP A CE2 1 
ATOM   3563 C  CE3 . TRP A 1 477 ? -25.041 15.766  7.498   1.00 51.39  ?  477 TRP A CE3 1 
ATOM   3564 C  CZ2 . TRP A 1 477 ? -25.812 17.874  9.219   1.00 50.94  ?  477 TRP A CZ2 1 
ATOM   3565 C  CZ3 . TRP A 1 477 ? -24.108 16.607  8.064   1.00 51.44  ?  477 TRP A CZ3 1 
ATOM   3566 C  CH2 . TRP A 1 477 ? -24.491 17.644  8.914   1.00 51.26  ?  477 TRP A CH2 1 
ATOM   3567 N  N   . SER A 1 478 ? -26.892 12.975  3.238   1.00 59.47  ?  478 SER A N   1 
ATOM   3568 C  CA  . SER A 1 478 ? -26.932 11.825  2.294   1.00 62.51  ?  478 SER A CA  1 
ATOM   3569 C  C   . SER A 1 478 ? -27.029 10.509  3.070   1.00 67.29  ?  478 SER A C   1 
ATOM   3570 O  O   . SER A 1 478 ? -26.892 10.539  4.303   1.00 70.50  ?  478 SER A O   1 
ATOM   3571 C  CB  . SER A 1 478 ? -25.725 11.829  1.407   1.00 63.48  ?  478 SER A CB  1 
ATOM   3572 O  OG  . SER A 1 478 ? -24.537 11.832  2.184   1.00 65.60  ?  478 SER A OG  1 
ATOM   3573 N  N   . GLU A 1 479 ? -27.255 9.397   2.364   1.00 74.62  ?  479 GLU A N   1 
ATOM   3574 C  CA  . GLU A 1 479 ? -27.258 8.031   2.958   1.00 76.35  ?  479 GLU A CA  1 
ATOM   3575 C  C   . GLU A 1 479 ? -25.839 7.705   3.440   1.00 69.94  ?  479 GLU A C   1 
ATOM   3576 O  O   . GLU A 1 479 ? -25.714 7.100   4.521   1.00 69.37  ?  479 GLU A O   1 
ATOM   3577 C  CB  . GLU A 1 479 ? -27.772 6.989   1.961   1.00 85.10  ?  479 GLU A CB  1 
ATOM   3578 C  CG  . GLU A 1 479 ? -29.287 6.874   1.933   1.00 93.94  ?  479 GLU A CG  1 
ATOM   3579 C  CD  . GLU A 1 479 ? -29.805 5.532   1.438   1.00 104.44 ?  479 GLU A CD  1 
ATOM   3580 O  OE1 . GLU A 1 479 ? -30.406 4.797   2.251   1.00 110.03 ?  479 GLU A OE1 1 
ATOM   3581 O  OE2 . GLU A 1 479 ? -29.609 5.224   0.243   1.00 111.02 ?  479 GLU A OE2 1 
ATOM   3582 N  N   . ALA A 1 480 ? -24.822 8.114   2.672   1.00 63.46  ?  480 ALA A N   1 
ATOM   3583 C  CA  . ALA A 1 480 ? -23.384 7.966   3.007   1.00 61.76  ?  480 ALA A CA  1 
ATOM   3584 C  C   . ALA A 1 480 ? -23.090 8.661   4.341   1.00 61.13  ?  480 ALA A C   1 
ATOM   3585 O  O   . ALA A 1 480 ? -22.414 8.045   5.189   1.00 61.79  ?  480 ALA A O   1 
ATOM   3586 C  CB  . ALA A 1 480 ? -22.521 8.525   1.901   1.00 60.90  ?  480 ALA A CB  1 
ATOM   3587 N  N   . ASP A 1 481 ? -23.581 9.894   4.510   1.00 60.65  ?  481 ASP A N   1 
ATOM   3588 C  CA  . ASP A 1 481 ? -23.432 10.696  5.756   1.00 61.40  ?  481 ASP A CA  1 
ATOM   3589 C  C   . ASP A 1 481 ? -23.951 9.894   6.952   1.00 60.81  ?  481 ASP A C   1 
ATOM   3590 O  O   . ASP A 1 481 ? -23.257 9.867   7.986   1.00 58.47  ?  481 ASP A O   1 
ATOM   3591 C  CB  . ASP A 1 481 ? -24.181 12.027  5.677   1.00 61.01  ?  481 ASP A CB  1 
ATOM   3592 C  CG  . ASP A 1 481 ? -23.569 13.033  4.722   1.00 61.63  ?  481 ASP A CG  1 
ATOM   3593 O  OD1 . ASP A 1 481 ? -22.386 12.868  4.362   1.00 62.60  ?  481 ASP A OD1 1 
ATOM   3594 O  OD2 . ASP A 1 481 ? -24.288 13.975  4.342   1.00 64.13  -1 481 ASP A OD2 1 
ATOM   3595 N  N   . ARG A 1 482 ? -25.115 9.256   6.803   1.00 62.68  ?  482 ARG A N   1 
ATOM   3596 C  CA  . ARG A 1 482 ? -25.808 8.561   7.925   1.00 67.65  ?  482 ARG A CA  1 
ATOM   3597 C  C   . ARG A 1 482 ? -25.116 7.221   8.207   1.00 64.60  ?  482 ARG A C   1 
ATOM   3598 O  O   . ARG A 1 482 ? -25.000 6.870   9.394   1.00 66.09  ?  482 ARG A O   1 
ATOM   3599 C  CB  . ARG A 1 482 ? -27.306 8.422   7.637   1.00 73.89  ?  482 ARG A CB  1 
ATOM   3600 C  CG  . ARG A 1 482 ? -28.130 9.609   8.120   1.00 80.35  ?  482 ARG A CG  1 
ATOM   3601 C  CD  . ARG A 1 482 ? -29.621 9.339   8.119   1.00 86.52  ?  482 ARG A CD  1 
ATOM   3602 N  NE  . ARG A 1 482 ? -30.168 9.452   6.774   1.00 92.44  ?  482 ARG A NE  1 
ATOM   3603 C  CZ  . ARG A 1 482 ? -30.543 10.589  6.191   1.00 98.17  ?  482 ARG A CZ  1 
ATOM   3604 N  NH1 . ARG A 1 482 ? -30.443 11.743  6.832   1.00 99.10  ?  482 ARG A NH1 1 
ATOM   3605 N  NH2 . ARG A 1 482 ? -31.024 10.565  4.960   1.00 101.06 ?  482 ARG A NH2 1 
ATOM   3606 N  N   . GLU A 1 483 ? -24.662 6.511   7.171   1.00 62.99  ?  483 GLU A N   1 
ATOM   3607 C  CA  . GLU A 1 483 ? -23.886 5.248   7.319   1.00 65.88  ?  483 GLU A CA  1 
ATOM   3608 C  C   . GLU A 1 483 ? -22.629 5.512   8.153   1.00 63.28  ?  483 GLU A C   1 
ATOM   3609 O  O   . GLU A 1 483 ? -22.351 4.716   9.071   1.00 63.31  ?  483 GLU A O   1 
ATOM   3610 C  CB  . GLU A 1 483 ? -23.472 4.678   5.962   1.00 73.92  ?  483 GLU A CB  1 
ATOM   3611 C  CG  . GLU A 1 483 ? -24.412 3.612   5.435   1.00 80.97  ?  483 GLU A CG  1 
ATOM   3612 C  CD  . GLU A 1 483 ? -23.822 2.780   4.310   1.00 86.61  ?  483 GLU A CD  1 
ATOM   3613 O  OE1 . GLU A 1 483 ? -24.481 2.669   3.257   1.00 89.89  ?  483 GLU A OE1 1 
ATOM   3614 O  OE2 . GLU A 1 483 ? -22.704 2.245   4.492   1.00 88.00  -1 483 GLU A OE2 1 
ATOM   3615 N  N   . ILE A 1 484 ? -21.895 6.578   7.823   1.00 57.86  ?  484 ILE A N   1 
ATOM   3616 C  CA  . ILE A 1 484 ? -20.605 6.949   8.478   1.00 54.57  ?  484 ILE A CA  1 
ATOM   3617 C  C   . ILE A 1 484 ? -20.886 7.358   9.928   1.00 52.88  ?  484 ILE A C   1 
ATOM   3618 O  O   . ILE A 1 484 ? -20.117 6.939   10.819  1.00 51.85  ?  484 ILE A O   1 
ATOM   3619 C  CB  . ILE A 1 484 ? -19.893 8.055   7.676   1.00 55.70  ?  484 ILE A CB  1 
ATOM   3620 C  CG1 . ILE A 1 484 ? -19.438 7.531   6.312   1.00 58.13  ?  484 ILE A CG1 1 
ATOM   3621 C  CG2 . ILE A 1 484 ? -18.736 8.654   8.466   1.00 55.53  ?  484 ILE A CG2 1 
ATOM   3622 C  CD1 . ILE A 1 484 ? -19.079 8.612   5.322   1.00 60.05  ?  484 ILE A CD1 1 
ATOM   3623 N  N   . ALA A 1 485 ? -21.946 8.142   10.147  1.00 51.37  ?  485 ALA A N   1 
ATOM   3624 C  CA  . ALA A 1 485 ? -22.379 8.626   11.481  1.00 51.20  ?  485 ALA A CA  1 
ATOM   3625 C  C   . ALA A 1 485 ? -22.741 7.430   12.369  1.00 50.50  ?  485 ALA A C   1 
ATOM   3626 O  O   . ALA A 1 485 ? -22.412 7.465   13.565  1.00 50.80  ?  485 ALA A O   1 
ATOM   3627 C  CB  . ALA A 1 485 ? -23.536 9.585   11.344  1.00 50.64  ?  485 ALA A CB  1 
ATOM   3628 N  N   . GLU A 1 486 ? -23.383 6.409   11.794  1.00 51.84  ?  486 GLU A N   1 
ATOM   3629 C  CA  . GLU A 1 486 ? -23.768 5.154   12.495  1.00 52.47  ?  486 GLU A CA  1 
ATOM   3630 C  C   . GLU A 1 486 ? -22.501 4.370   12.868  1.00 52.39  ?  486 GLU A C   1 
ATOM   3631 O  O   . GLU A 1 486 ? -22.406 3.930   14.023  1.00 53.83  ?  486 GLU A O   1 
ATOM   3632 C  CB  . GLU A 1 486 ? -24.734 4.341   11.630  1.00 53.79  ?  486 GLU A CB  1 
ATOM   3633 C  CG  . GLU A 1 486 ? -25.125 2.994   12.220  1.00 57.19  ?  486 GLU A CG  1 
ATOM   3634 C  CD  . GLU A 1 486 ? -25.843 3.012   13.564  1.00 59.34  ?  486 GLU A CD  1 
ATOM   3635 O  OE1 . GLU A 1 486 ? -26.228 1.918   14.031  1.00 60.54  ?  486 GLU A OE1 1 
ATOM   3636 O  OE2 . GLU A 1 486 ? -26.013 4.105   14.151  1.00 56.57  -1 486 GLU A OE2 1 
ATOM   3637 N  N   . THR A 1 487 ? -21.557 4.211   11.937  1.00 52.23  ?  487 THR A N   1 
ATOM   3638 C  CA  . THR A 1 487 ? -20.259 3.525   12.191  1.00 53.14  ?  487 THR A CA  1 
ATOM   3639 C  C   . THR A 1 487 ? -19.469 4.284   13.269  1.00 52.88  ?  487 THR A C   1 
ATOM   3640 O  O   . THR A 1 487 ? -18.816 3.622   14.092  1.00 55.00  ?  487 THR A O   1 
ATOM   3641 C  CB  . THR A 1 487 ? -19.441 3.376   10.903  1.00 54.76  ?  487 THR A CB  1 
ATOM   3642 O  OG1 . THR A 1 487 ? -20.259 2.721   9.934   1.00 56.89  ?  487 THR A OG1 1 
ATOM   3643 C  CG2 . THR A 1 487 ? -18.169 2.581   11.101  1.00 56.04  ?  487 THR A CG2 1 
ATOM   3644 N  N   . ALA A 1 488 ? -19.507 5.618   13.250  1.00 51.24  ?  488 ALA A N   1 
ATOM   3645 C  CA  . ALA A 1 488 ? -18.851 6.494   14.249  1.00 50.69  ?  488 ALA A CA  1 
ATOM   3646 C  C   . ALA A 1 488 ? -19.501 6.292   15.625  1.00 50.22  ?  488 ALA A C   1 
ATOM   3647 O  O   . ALA A 1 488 ? -18.754 6.144   16.617  1.00 49.48  ?  488 ALA A O   1 
ATOM   3648 C  CB  . ALA A 1 488 ? -18.929 7.933   13.806  1.00 51.86  ?  488 ALA A CB  1 
ATOM   3649 N  N   . ARG A 1 489 ? -20.838 6.269   15.676  1.00 49.21  ?  489 ARG A N   1 
ATOM   3650 C  CA  . ARG A 1 489 ? -21.619 6.005   16.922  1.00 50.83  ?  489 ARG A CA  1 
ATOM   3651 C  C   . ARG A 1 489 ? -21.114 4.710   17.569  1.00 50.05  ?  489 ARG A C   1 
ATOM   3652 O  O   . ARG A 1 489 ? -20.770 4.737   18.763  1.00 50.28  ?  489 ARG A O   1 
ATOM   3653 C  CB  . ARG A 1 489 ? -23.116 5.878   16.625  1.00 52.96  ?  489 ARG A CB  1 
ATOM   3654 C  CG  . ARG A 1 489 ? -23.998 5.752   17.860  1.00 54.95  ?  489 ARG A CG  1 
ATOM   3655 C  CD  . ARG A 1 489 ? -25.452 5.468   17.516  1.00 57.70  ?  489 ARG A CD  1 
ATOM   3656 N  NE  . ARG A 1 489 ? -25.626 4.160   16.891  1.00 59.04  ?  489 ARG A NE  1 
ATOM   3657 C  CZ  . ARG A 1 489 ? -25.736 3.004   17.544  1.00 58.94  ?  489 ARG A CZ  1 
ATOM   3658 N  NH1 . ARG A 1 489 ? -25.703 2.969   18.867  1.00 59.06  ?  489 ARG A NH1 1 
ATOM   3659 N  NH2 . ARG A 1 489 ? -25.877 1.879   16.868  1.00 59.52  ?  489 ARG A NH2 1 
ATOM   3660 N  N   . ILE A 1 490 ? -21.057 3.626   16.794  1.00 49.26  ?  490 ILE A N   1 
ATOM   3661 C  CA  . ILE A 1 490 ? -20.686 2.265   17.282  1.00 48.55  ?  490 ILE A CA  1 
ATOM   3662 C  C   . ILE A 1 490 ? -19.241 2.290   17.788  1.00 48.80  ?  490 ILE A C   1 
ATOM   3663 O  O   . ILE A 1 490 ? -18.969 1.641   18.810  1.00 51.84  ?  490 ILE A O   1 
ATOM   3664 C  CB  . ILE A 1 490 ? -20.923 1.205   16.190  1.00 47.81  ?  490 ILE A CB  1 
ATOM   3665 C  CG1 . ILE A 1 490 ? -22.422 1.004   15.947  1.00 49.53  ?  490 ILE A CG1 1 
ATOM   3666 C  CG2 . ILE A 1 490 ? -20.233 -0.104  16.541  1.00 48.24  ?  490 ILE A CG2 1 
ATOM   3667 C  CD1 . ILE A 1 490 ? -22.761 0.317   14.643  1.00 49.67  ?  490 ILE A CD1 1 
ATOM   3668 N  N   . ALA A 1 491 ? -18.356 3.022   17.113  1.00 50.05  ?  491 ALA A N   1 
ATOM   3669 C  CA  . ALA A 1 491 ? -16.922 3.129   17.472  1.00 51.81  ?  491 ALA A CA  1 
ATOM   3670 C  C   . ALA A 1 491 ? -16.770 3.895   18.792  1.00 54.41  ?  491 ALA A C   1 
ATOM   3671 O  O   . ALA A 1 491 ? -15.981 3.442   19.638  1.00 57.24  ?  491 ALA A O   1 
ATOM   3672 C  CB  . ALA A 1 491 ? -16.149 3.792   16.362  1.00 51.81  ?  491 ALA A CB  1 
ATOM   3673 N  N   . LEU A 1 492 ? -17.501 5.004   18.952  1.00 56.19  ?  492 LEU A N   1 
ATOM   3674 C  CA  . LEU A 1 492 ? -17.361 5.950   20.094  1.00 58.13  ?  492 LEU A CA  1 
ATOM   3675 C  C   . LEU A 1 492 ? -18.061 5.391   21.338  1.00 59.17  ?  492 LEU A C   1 
ATOM   3676 O  O   . LEU A 1 492 ? -17.506 5.539   22.440  1.00 61.94  ?  492 LEU A O   1 
ATOM   3677 C  CB  . LEU A 1 492 ? -17.935 7.316   19.699  1.00 60.20  ?  492 LEU A CB  1 
ATOM   3678 C  CG  . LEU A 1 492 ? -17.105 8.104   18.686  1.00 61.64  ?  492 LEU A CG  1 
ATOM   3679 C  CD1 . LEU A 1 492 ? -17.863 9.316   18.170  1.00 61.12  ?  492 LEU A CD1 1 
ATOM   3680 C  CD2 . LEU A 1 492 ? -15.780 8.534   19.293  1.00 64.64  ?  492 LEU A CD2 1 
ATOM   3681 N  N   . VAL A 1 493 ? -19.240 4.788   21.168  1.00 60.37  ?  493 VAL A N   1 
ATOM   3682 C  CA  . VAL A 1 493 ? -19.993 4.085   22.253  1.00 58.92  ?  493 VAL A CA  1 
ATOM   3683 C  C   . VAL A 1 493 ? -19.189 2.850   22.684  1.00 58.19  ?  493 VAL A C   1 
ATOM   3684 O  O   . VAL A 1 493 ? -19.209 2.520   23.883  1.00 57.97  ?  493 VAL A O   1 
ATOM   3685 C  CB  . VAL A 1 493 ? -21.419 3.724   21.792  1.00 58.76  ?  493 VAL A CB  1 
ATOM   3686 C  CG1 . VAL A 1 493 ? -22.066 2.661   22.660  1.00 60.46  ?  493 VAL A CG1 1 
ATOM   3687 C  CG2 . VAL A 1 493 ? -22.306 4.956   21.723  1.00 59.41  ?  493 VAL A CG2 1 
ATOM   3688 N  N   . GLY A 1 494 ? -18.497 2.210   21.738  1.00 59.08  ?  494 GLY A N   1 
ATOM   3689 C  CA  . GLY A 1 494 ? -17.650 1.025   21.973  1.00 61.44  ?  494 GLY A CA  1 
ATOM   3690 C  C   . GLY A 1 494 ? -16.500 1.305   22.931  1.00 63.87  ?  494 GLY A C   1 
ATOM   3691 O  O   . GLY A 1 494 ? -16.305 0.489   23.849  1.00 67.15  ?  494 GLY A O   1 
ATOM   3692 N  N   . VAL A 1 495 ? -15.761 2.402   22.728  1.00 63.60  ?  495 VAL A N   1 
ATOM   3693 C  CA  . VAL A 1 495 ? -14.555 2.758   23.543  1.00 65.43  ?  495 VAL A CA  1 
ATOM   3694 C  C   . VAL A 1 495 ? -14.985 3.470   24.831  1.00 66.84  ?  495 VAL A C   1 
ATOM   3695 O  O   . VAL A 1 495 ? -14.254 3.354   25.831  1.00 69.94  ?  495 VAL A O   1 
ATOM   3696 C  CB  . VAL A 1 495 ? -13.529 3.604   22.765  1.00 66.75  ?  495 VAL A CB  1 
ATOM   3697 C  CG1 . VAL A 1 495 ? -12.817 2.772   21.717  1.00 68.51  ?  495 VAL A CG1 1 
ATOM   3698 C  CG2 . VAL A 1 495 ? -14.129 4.861   22.150  1.00 66.70  ?  495 VAL A CG2 1 
ATOM   3699 N  N   . ALA A 1 496 ? -16.106 4.196   24.802  1.00 66.92  ?  496 ALA A N   1 
ATOM   3700 C  CA  . ALA A 1 496 ? -16.730 4.818   25.995  1.00 68.36  ?  496 ALA A CA  1 
ATOM   3701 C  C   . ALA A 1 496 ? -17.080 3.730   27.020  1.00 69.99  ?  496 ALA A C   1 
ATOM   3702 O  O   . ALA A 1 496 ? -16.980 4.006   28.228  1.00 73.92  ?  496 ALA A O   1 
ATOM   3703 C  CB  . ALA A 1 496 ? -17.948 5.614   25.600  1.00 68.29  ?  496 ALA A CB  1 
ATOM   3704 N  N   . PHE A 1 497 ? -17.471 2.542   26.550  1.00 70.06  ?  497 PHE A N   1 
ATOM   3705 C  CA  . PHE A 1 497 ? -17.804 1.367   27.399  1.00 71.65  ?  497 PHE A CA  1 
ATOM   3706 C  C   . PHE A 1 497 ? -16.524 0.794   28.021  1.00 76.77  ?  497 PHE A C   1 
ATOM   3707 O  O   . PHE A 1 497 ? -16.502 0.587   29.246  1.00 83.27  ?  497 PHE A O   1 
ATOM   3708 C  CB  . PHE A 1 497 ? -18.551 0.304   26.592  1.00 68.89  ?  497 PHE A CB  1 
ATOM   3709 C  CG  . PHE A 1 497 ? -19.331 -0.666  27.439  1.00 68.01  ?  497 PHE A CG  1 
ATOM   3710 C  CD1 . PHE A 1 497 ? -20.343 -0.215  28.275  1.00 69.43  ?  497 PHE A CD1 1 
ATOM   3711 C  CD2 . PHE A 1 497 ? -19.054 -2.023  27.409  1.00 68.30  ?  497 PHE A CD2 1 
ATOM   3712 C  CE1 . PHE A 1 497 ? -21.063 -1.101  29.062  1.00 69.53  ?  497 PHE A CE1 1 
ATOM   3713 C  CE2 . PHE A 1 497 ? -19.774 -2.908  28.197  1.00 70.52  ?  497 PHE A CE2 1 
ATOM   3714 C  CZ  . PHE A 1 497 ? -20.778 -2.446  29.020  1.00 71.06  ?  497 PHE A CZ  1 
ATOM   3715 N  N   . HIS A 1 498 ? -15.500 0.552   27.195  1.00 81.32  ?  498 HIS A N   1 
ATOM   3716 C  CA  . HIS A 1 498 ? -14.160 0.029   27.586  1.00 86.06  ?  498 HIS A CA  1 
ATOM   3717 C  C   . HIS A 1 498 ? -13.531 0.909   28.678  1.00 89.77  ?  498 HIS A C   1 
ATOM   3718 O  O   . HIS A 1 498 ? -12.819 0.352   29.535  1.00 93.13  ?  498 HIS A O   1 
ATOM   3719 C  CB  . HIS A 1 498 ? -13.268 -0.079  26.338  1.00 91.05  ?  498 HIS A CB  1 
ATOM   3720 C  CG  . HIS A 1 498 ? -11.887 -0.593  26.584  1.00 97.15  ?  498 HIS A CG  1 
ATOM   3721 N  ND1 . HIS A 1 498 ? -10.955 0.108   27.328  1.00 100.18 ?  498 HIS A ND1 1 
ATOM   3722 C  CD2 . HIS A 1 498 ? -11.259 -1.706  26.144  1.00 100.13 ?  498 HIS A CD2 1 
ATOM   3723 C  CE1 . HIS A 1 498 ? -9.823  -0.567  27.359  1.00 102.77 ?  498 HIS A CE1 1 
ATOM   3724 N  NE2 . HIS A 1 498 ? -9.983  -1.683  26.638  1.00 101.19 ?  498 HIS A NE2 1 
ATOM   3725 N  N   . HIS A 1 499 ? -13.791 2.222   28.649  1.00 94.15  ?  499 HIS A N   1 
ATOM   3726 C  CA  . HIS A 1 499 ? -13.189 3.246   29.551  1.00 96.99  ?  499 HIS A CA  1 
ATOM   3727 C  C   . HIS A 1 499 ? -14.153 3.604   30.690  1.00 103.01 ?  499 HIS A C   1 
ATOM   3728 O  O   . HIS A 1 499 ? -14.201 4.793   31.068  1.00 107.35 ?  499 HIS A O   1 
ATOM   3729 C  CB  . HIS A 1 499 ? -12.786 4.486   28.738  1.00 96.16  ?  499 HIS A CB  1 
ATOM   3730 C  CG  . HIS A 1 499 ? -11.550 4.287   27.931  1.00 95.88  ?  499 HIS A CG  1 
ATOM   3731 N  ND1 . HIS A 1 499 ? -10.429 5.068   28.106  1.00 97.22  ?  499 HIS A ND1 1 
ATOM   3732 C  CD2 . HIS A 1 499 ? -11.246 3.390   26.969  1.00 97.50  ?  499 HIS A CD2 1 
ATOM   3733 C  CE1 . HIS A 1 499 ? -9.487  4.668   27.278  1.00 99.91  ?  499 HIS A CE1 1 
ATOM   3734 N  NE2 . HIS A 1 499 ? -9.963  3.639   26.567  1.00 98.59  ?  499 HIS A NE2 1 
ATOM   3735 N  N   . SER A 1 500 ? -14.882 2.618   31.223  1.00 109.27 ?  500 SER A N   1 
ATOM   3736 C  CA  . SER A 1 500 ? -15.855 2.792   32.337  1.00 113.84 ?  500 SER A CA  1 
ATOM   3737 C  C   . SER A 1 500 ? -15.745 1.614   33.312  1.00 117.04 ?  500 SER A C   1 
ATOM   3738 O  O   . SER A 1 500 ? -15.700 1.802   34.530  1.00 118.38 ?  500 SER A O   1 
ATOM   3739 C  CB  . SER A 1 500 ? -17.261 2.947   31.808  1.00 114.44 ?  500 SER A CB  1 
ATOM   3740 O  OG  . SER A 1 500 ? -17.447 4.237   31.244  1.00 114.42 ?  500 SER A OG  1 
ATOM   3741 N  N   . ASP B 1 5   ? -51.109 -5.860  -19.788 1.00 137.81 ?  5   ASP B N   1 
ATOM   3742 C  CA  . ASP B 1 5   ? -50.095 -5.798  -20.889 1.00 140.22 ?  5   ASP B CA  1 
ATOM   3743 C  C   . ASP B 1 5   ? -50.818 -5.616  -22.232 1.00 137.99 ?  5   ASP B C   1 
ATOM   3744 O  O   . ASP B 1 5   ? -50.464 -4.674  -22.971 1.00 136.32 ?  5   ASP B O   1 
ATOM   3745 C  CB  . ASP B 1 5   ? -49.201 -7.043  -20.890 1.00 142.44 ?  5   ASP B CB  1 
ATOM   3746 C  CG  . ASP B 1 5   ? -47.888 -6.871  -21.639 1.00 143.60 ?  5   ASP B CG  1 
ATOM   3747 O  OD1 . ASP B 1 5   ? -47.267 -5.796  -21.504 1.00 139.97 ?  5   ASP B OD1 1 
ATOM   3748 O  OD2 . ASP B 1 5   ? -47.492 -7.817  -22.349 1.00 145.61 ?  5   ASP B OD2 1 
ATOM   3749 N  N   . TYR B 1 6   ? -51.787 -6.491  -22.524 1.00 132.95 ?  6   TYR B N   1 
ATOM   3750 C  CA  . TYR B 1 6   ? -52.664 -6.452  -23.726 1.00 124.43 ?  6   TYR B CA  1 
ATOM   3751 C  C   . TYR B 1 6   ? -53.891 -5.583  -23.424 1.00 121.43 ?  6   TYR B C   1 
ATOM   3752 O  O   . TYR B 1 6   ? -54.699 -5.973  -22.557 1.00 120.55 ?  6   TYR B O   1 
ATOM   3753 C  CB  . TYR B 1 6   ? -53.073 -7.874  -24.128 1.00 120.08 ?  6   TYR B CB  1 
ATOM   3754 C  CG  . TYR B 1 6   ? -53.660 -8.020  -25.511 1.00 116.91 ?  6   TYR B CG  1 
ATOM   3755 C  CD1 . TYR B 1 6   ? -55.009 -7.801  -25.749 1.00 112.32 ?  6   TYR B CD1 1 
ATOM   3756 C  CD2 . TYR B 1 6   ? -52.871 -8.407  -26.583 1.00 115.38 ?  6   TYR B CD2 1 
ATOM   3757 C  CE1 . TYR B 1 6   ? -55.554 -7.946  -27.016 1.00 108.73 ?  6   TYR B CE1 1 
ATOM   3758 C  CE2 . TYR B 1 6   ? -53.399 -8.559  -27.856 1.00 111.03 ?  6   TYR B CE2 1 
ATOM   3759 C  CZ  . TYR B 1 6   ? -54.746 -8.328  -28.073 1.00 107.87 ?  6   TYR B CZ  1 
ATOM   3760 O  OH  . TYR B 1 6   ? -55.269 -8.479  -29.324 1.00 100.81 ?  6   TYR B OH  1 
ATOM   3761 N  N   . HIS B 1 7   ? -54.016 -4.438  -24.106 1.00 116.11 ?  7   HIS B N   1 
ATOM   3762 C  CA  . HIS B 1 7   ? -55.153 -3.484  -23.969 1.00 115.76 ?  7   HIS B CA  1 
ATOM   3763 C  C   . HIS B 1 7   ? -56.133 -3.707  -25.128 1.00 107.79 ?  7   HIS B C   1 
ATOM   3764 O  O   . HIS B 1 7   ? -55.873 -3.183  -26.229 1.00 108.22 ?  7   HIS B O   1 
ATOM   3765 C  CB  . HIS B 1 7   ? -54.630 -2.044  -23.854 1.00 119.88 ?  7   HIS B CB  1 
ATOM   3766 C  CG  . HIS B 1 7   ? -53.897 -1.785  -22.577 1.00 127.84 ?  7   HIS B CG  1 
ATOM   3767 N  ND1 . HIS B 1 7   ? -54.495 -1.175  -21.488 1.00 132.79 ?  7   HIS B ND1 1 
ATOM   3768 C  CD2 . HIS B 1 7   ? -52.631 -2.069  -22.201 1.00 128.62 ?  7   HIS B CD2 1 
ATOM   3769 C  CE1 . HIS B 1 7   ? -53.623 -1.084  -20.502 1.00 130.31 ?  7   HIS B CE1 1 
ATOM   3770 N  NE2 . HIS B 1 7   ? -52.472 -1.627  -20.914 1.00 129.48 ?  7   HIS B NE2 1 
ATOM   3771 N  N   . VAL B 1 8   ? -57.215 -4.454  -24.871 1.00 97.55  ?  8   VAL B N   1 
ATOM   3772 C  CA  . VAL B 1 8   ? -58.131 -5.026  -25.908 1.00 90.41  ?  8   VAL B CA  1 
ATOM   3773 C  C   . VAL B 1 8   ? -59.234 -4.014  -26.256 1.00 83.05  ?  8   VAL B C   1 
ATOM   3774 O  O   . VAL B 1 8   ? -59.777 -3.376  -25.333 1.00 80.33  ?  8   VAL B O   1 
ATOM   3775 C  CB  . VAL B 1 8   ? -58.722 -6.382  -25.466 1.00 89.49  ?  8   VAL B CB  1 
ATOM   3776 C  CG1 . VAL B 1 8   ? -59.667 -6.260  -24.279 1.00 88.55  ?  8   VAL B CG1 1 
ATOM   3777 C  CG2 . VAL B 1 8   ? -59.416 -7.093  -26.618 1.00 90.00  ?  8   VAL B CG2 1 
ATOM   3778 N  N   . ASP B 1 9   ? -59.541 -3.893  -27.551 1.00 77.72  ?  9   ASP B N   1 
ATOM   3779 C  CA  . ASP B 1 9   ? -60.671 -3.093  -28.100 1.00 79.53  ?  9   ASP B CA  1 
ATOM   3780 C  C   . ASP B 1 9   ? -61.209 -3.807  -29.351 1.00 77.76  ?  9   ASP B C   1 
ATOM   3781 O  O   . ASP B 1 9   ? -60.757 -4.933  -29.624 1.00 74.42  ?  9   ASP B O   1 
ATOM   3782 C  CB  . ASP B 1 9   ? -60.239 -1.645  -28.357 1.00 82.55  ?  9   ASP B CB  1 
ATOM   3783 C  CG  . ASP B 1 9   ? -59.263 -1.467  -29.510 1.00 84.73  ?  9   ASP B CG  1 
ATOM   3784 O  OD1 . ASP B 1 9   ? -58.472 -2.398  -29.762 1.00 87.99  ?  9   ASP B OD1 1 
ATOM   3785 O  OD2 . ASP B 1 9   ? -59.304 -0.400  -30.152 1.00 86.05  ?  9   ASP B OD2 1 
ATOM   3786 N  N   . LEU B 1 10  ? -62.115 -3.169  -30.101 1.00 76.84  ?  10  LEU B N   1 
ATOM   3787 C  CA  . LEU B 1 10  ? -62.821 -3.788  -31.259 1.00 78.13  ?  10  LEU B CA  1 
ATOM   3788 C  C   . LEU B 1 10  ? -61.883 -3.948  -32.462 1.00 79.12  ?  10  LEU B C   1 
ATOM   3789 O  O   . LEU B 1 10  ? -62.345 -4.506  -33.479 1.00 82.49  ?  10  LEU B O   1 
ATOM   3790 C  CB  . LEU B 1 10  ? -64.032 -2.932  -31.642 1.00 77.02  ?  10  LEU B CB  1 
ATOM   3791 C  CG  . LEU B 1 10  ? -65.082 -2.731  -30.551 1.00 78.11  ?  10  LEU B CG  1 
ATOM   3792 C  CD1 . LEU B 1 10  ? -66.333 -2.098  -31.136 1.00 79.91  ?  10  LEU B CD1 1 
ATOM   3793 C  CD2 . LEU B 1 10  ? -65.423 -4.040  -29.852 1.00 78.26  ?  10  LEU B CD2 1 
ATOM   3794 N  N   . THR B 1 11  ? -60.629 -3.497  -32.358 1.00 78.13  ?  11  THR B N   1 
ATOM   3795 C  CA  . THR B 1 11  ? -59.632 -3.557  -33.469 1.00 79.24  ?  11  THR B CA  1 
ATOM   3796 C  C   . THR B 1 11  ? -58.767 -4.820  -33.349 1.00 78.00  ?  11  THR B C   1 
ATOM   3797 O  O   . THR B 1 11  ? -58.246 -5.263  -34.390 1.00 79.10  ?  11  THR B O   1 
ATOM   3798 C  CB  . THR B 1 11  ? -58.741 -2.309  -33.508 1.00 80.91  ?  11  THR B CB  1 
ATOM   3799 O  OG1 . THR B 1 11  ? -57.859 -2.367  -32.386 1.00 83.57  ?  11  THR B OG1 1 
ATOM   3800 C  CG2 . THR B 1 11  ? -59.530 -1.017  -33.492 1.00 80.23  ?  11  THR B CG2 1 
ATOM   3801 N  N   . ASN B 1 12  ? -58.612 -5.374  -32.141 1.00 75.79  ?  12  ASN B N   1 
ATOM   3802 C  CA  . ASN B 1 12  ? -57.637 -6.465  -31.858 1.00 76.10  ?  12  ASN B CA  1 
ATOM   3803 C  C   . ASN B 1 12  ? -58.272 -7.608  -31.049 1.00 77.96  ?  12  ASN B C   1 
ATOM   3804 O  O   . ASN B 1 12  ? -57.541 -8.577  -30.739 1.00 77.58  ?  12  ASN B O   1 
ATOM   3805 C  CB  . ASN B 1 12  ? -56.409 -5.903  -31.139 1.00 77.29  ?  12  ASN B CB  1 
ATOM   3806 C  CG  . ASN B 1 12  ? -56.755 -5.184  -29.852 1.00 77.10  ?  12  ASN B CG  1 
ATOM   3807 O  OD1 . ASN B 1 12  ? -57.860 -5.319  -29.334 1.00 76.17  ?  12  ASN B OD1 1 
ATOM   3808 N  ND2 . ASN B 1 12  ? -55.819 -4.410  -29.332 1.00 80.83  ?  12  ASN B ND2 1 
ATOM   3809 N  N   . CYS B 1 13  ? -59.567 -7.513  -30.723 1.00 76.83  ?  13  CYS B N   1 
ATOM   3810 C  CA  . CYS B 1 13  ? -60.304 -8.510  -29.888 1.00 74.78  ?  13  CYS B CA  1 
ATOM   3811 C  C   . CYS B 1 13  ? -60.408 -9.857  -30.617 1.00 72.24  ?  13  CYS B C   1 
ATOM   3812 O  O   . CYS B 1 13  ? -60.636 -10.878 -29.940 1.00 71.20  ?  13  CYS B O   1 
ATOM   3813 C  CB  . CYS B 1 13  ? -61.707 -8.033  -29.518 1.00 76.10  ?  13  CYS B CB  1 
ATOM   3814 S  SG  . CYS B 1 13  ? -62.908 -8.091  -30.897 1.00 78.07  ?  13  CYS B SG  1 
ATOM   3815 N  N   . ASP B 1 14  ? -60.263 -9.852  -31.945 1.00 70.33  ?  14  ASP B N   1 
ATOM   3816 C  CA  . ASP B 1 14  ? -60.260 -11.075 -32.794 1.00 73.23  ?  14  ASP B CA  1 
ATOM   3817 C  C   . ASP B 1 14  ? -59.067 -11.965 -32.425 1.00 72.33  ?  14  ASP B C   1 
ATOM   3818 O  O   . ASP B 1 14  ? -59.181 -13.193 -32.604 1.00 71.51  ?  14  ASP B O   1 
ATOM   3819 C  CB  . ASP B 1 14  ? -60.231 -10.723 -34.283 1.00 76.58  ?  14  ASP B CB  1 
ATOM   3820 C  CG  . ASP B 1 14  ? -59.016 -9.909  -34.691 1.00 79.79  ?  14  ASP B CG  1 
ATOM   3821 O  OD1 . ASP B 1 14  ? -58.707 -8.932  -33.981 1.00 83.57  ?  14  ASP B OD1 1 
ATOM   3822 O  OD2 . ASP B 1 14  ? -58.385 -10.264 -35.707 1.00 80.57  ?  14  ASP B OD2 1 
ATOM   3823 N  N   . ARG B 1 15  ? -57.966 -11.366 -31.952 1.00 75.06  ?  15  ARG B N   1 
ATOM   3824 C  CA  . ARG B 1 15  ? -56.709 -12.089 -31.597 1.00 71.76  ?  15  ARG B CA  1 
ATOM   3825 C  C   . ARG B 1 15  ? -56.368 -11.871 -30.113 1.00 69.83  ?  15  ARG B C   1 
ATOM   3826 O  O   . ARG B 1 15  ? -55.175 -11.954 -29.776 1.00 74.04  ?  15  ARG B O   1 
ATOM   3827 C  CB  . ARG B 1 15  ? -55.575 -11.623 -32.520 1.00 67.86  ?  15  ARG B CB  1 
ATOM   3828 N  N   . GLU B 1 16  ? -57.365 -11.632 -29.251 1.00 66.53  ?  16  GLU B N   1 
ATOM   3829 C  CA  . GLU B 1 16  ? -57.158 -11.432 -27.788 1.00 68.26  ?  16  GLU B CA  1 
ATOM   3830 C  C   . GLU B 1 16  ? -56.684 -12.743 -27.164 1.00 72.69  ?  16  GLU B C   1 
ATOM   3831 O  O   . GLU B 1 16  ? -57.273 -13.793 -27.417 1.00 77.22  ?  16  GLU B O   1 
ATOM   3832 C  CB  . GLU B 1 16  ? -58.437 -10.953 -27.093 1.00 68.40  ?  16  GLU B CB  1 
ATOM   3833 C  CG  . GLU B 1 16  ? -58.315 -10.856 -25.576 1.00 67.77  ?  16  GLU B CG  1 
ATOM   3834 C  CD  . GLU B 1 16  ? -59.591 -10.511 -24.824 1.00 68.73  ?  16  GLU B CD  1 
ATOM   3835 O  OE1 . GLU B 1 16  ? -60.634 -10.328 -25.481 1.00 69.47  ?  16  GLU B OE1 1 
ATOM   3836 O  OE2 . GLU B 1 16  ? -59.539 -10.429 -23.575 1.00 67.00  ?  16  GLU B OE2 1 
ATOM   3837 N  N   . PRO B 1 17  ? -55.616 -12.727 -26.329 1.00 74.73  ?  17  PRO B N   1 
ATOM   3838 C  CA  . PRO B 1 17  ? -55.161 -13.929 -25.626 1.00 74.09  ?  17  PRO B CA  1 
ATOM   3839 C  C   . PRO B 1 17  ? -55.975 -14.188 -24.348 1.00 74.33  ?  17  PRO B C   1 
ATOM   3840 O  O   . PRO B 1 17  ? -55.515 -13.850 -23.270 1.00 77.19  ?  17  PRO B O   1 
ATOM   3841 C  CB  . PRO B 1 17  ? -53.698 -13.577 -25.318 1.00 74.43  ?  17  PRO B CB  1 
ATOM   3842 C  CG  . PRO B 1 17  ? -53.741 -12.085 -25.053 1.00 73.27  ?  17  PRO B CG  1 
ATOM   3843 C  CD  . PRO B 1 17  ? -54.785 -11.552 -26.015 1.00 72.59  ?  17  PRO B CD  1 
ATOM   3844 N  N   . ILE B 1 18  ? -57.158 -14.790 -24.504 1.00 72.84  ?  18  ILE B N   1 
ATOM   3845 C  CA  . ILE B 1 18  ? -58.171 -14.966 -23.415 1.00 71.49  ?  18  ILE B CA  1 
ATOM   3846 C  C   . ILE B 1 18  ? -57.738 -16.076 -22.450 1.00 67.74  ?  18  ILE B C   1 
ATOM   3847 O  O   . ILE B 1 18  ? -58.349 -16.178 -21.372 1.00 64.86  ?  18  ILE B O   1 
ATOM   3848 C  CB  . ILE B 1 18  ? -59.576 -15.236 -23.993 1.00 74.25  ?  18  ILE B CB  1 
ATOM   3849 C  CG1 . ILE B 1 18  ? -59.602 -16.447 -24.930 1.00 73.25  ?  18  ILE B CG1 1 
ATOM   3850 C  CG2 . ILE B 1 18  ? -60.114 -13.986 -24.674 1.00 76.26  ?  18  ILE B CG2 1 
ATOM   3851 C  CD1 . ILE B 1 18  ? -60.981 -17.007 -25.176 1.00 74.01  ?  18  ILE B CD1 1 
ATOM   3852 N  N   . HIS B 1 19  ? -56.736 -16.876 -22.824 1.00 69.17  ?  19  HIS B N   1 
ATOM   3853 C  CA  . HIS B 1 19  ? -56.244 -18.036 -22.030 1.00 69.90  ?  19  HIS B CA  1 
ATOM   3854 C  C   . HIS B 1 19  ? -55.313 -17.559 -20.907 1.00 69.12  ?  19  HIS B C   1 
ATOM   3855 O  O   . HIS B 1 19  ? -55.158 -18.315 -19.923 1.00 68.24  ?  19  HIS B O   1 
ATOM   3856 C  CB  . HIS B 1 19  ? -55.591 -19.087 -22.941 1.00 70.80  ?  19  HIS B CB  1 
ATOM   3857 C  CG  . HIS B 1 19  ? -54.402 -18.600 -23.697 1.00 72.16  ?  19  HIS B CG  1 
ATOM   3858 N  ND1 . HIS B 1 19  ? -54.506 -17.682 -24.724 1.00 72.94  ?  19  HIS B ND1 1 
ATOM   3859 C  CD2 . HIS B 1 19  ? -53.092 -18.913 -23.598 1.00 72.81  ?  19  HIS B CD2 1 
ATOM   3860 C  CE1 . HIS B 1 19  ? -53.309 -17.438 -25.215 1.00 74.15  ?  19  HIS B CE1 1 
ATOM   3861 N  NE2 . HIS B 1 19  ? -52.423 -18.183 -24.542 1.00 75.03  ?  19  HIS B NE2 1 
ATOM   3862 N  N   . ILE B 1 20  ? -54.748 -16.349 -21.029 1.00 68.52  ?  20  ILE B N   1 
ATOM   3863 C  CA  . ILE B 1 20  ? -53.766 -15.773 -20.057 1.00 68.22  ?  20  ILE B CA  1 
ATOM   3864 C  C   . ILE B 1 20  ? -54.233 -14.389 -19.604 1.00 69.41  ?  20  ILE B C   1 
ATOM   3865 O  O   . ILE B 1 20  ? -53.530 -13.399 -19.795 1.00 71.17  ?  20  ILE B O   1 
ATOM   3866 C  CB  . ILE B 1 20  ? -52.352 -15.741 -20.675 1.00 66.43  ?  20  ILE B CB  1 
ATOM   3867 C  CG1 . ILE B 1 20  ? -52.348 -15.112 -22.071 1.00 66.02  ?  20  ILE B CG1 1 
ATOM   3868 C  CG2 . ILE B 1 20  ? -51.748 -17.135 -20.694 1.00 66.82  ?  20  ILE B CG2 1 
ATOM   3869 C  CD1 . ILE B 1 20  ? -51.028 -14.495 -22.462 1.00 66.01  ?  20  ILE B CD1 1 
ATOM   3870 N  N   . PRO B 1 21  ? -55.426 -14.270 -18.976 1.00 72.36  ?  21  PRO B N   1 
ATOM   3871 C  CA  . PRO B 1 21  ? -55.977 -12.963 -18.611 1.00 71.33  ?  21  PRO B CA  1 
ATOM   3872 C  C   . PRO B 1 21  ? -55.264 -12.306 -17.418 1.00 71.03  ?  21  PRO B C   1 
ATOM   3873 O  O   . PRO B 1 21  ? -55.298 -11.093 -17.314 1.00 71.42  ?  21  PRO B O   1 
ATOM   3874 C  CB  . PRO B 1 21  ? -57.429 -13.303 -18.238 1.00 70.18  ?  21  PRO B CB  1 
ATOM   3875 C  CG  . PRO B 1 21  ? -57.335 -14.708 -17.686 1.00 69.29  ?  21  PRO B CG  1 
ATOM   3876 C  CD  . PRO B 1 21  ? -56.306 -15.380 -18.571 1.00 70.64  ?  21  PRO B CD  1 
ATOM   3877 N  N   . GLY B 1 22  ? -54.667 -13.118 -16.540 1.00 70.04  ?  22  GLY B N   1 
ATOM   3878 C  CA  . GLY B 1 22  ? -53.987 -12.651 -15.317 1.00 72.66  ?  22  GLY B CA  1 
ATOM   3879 C  C   . GLY B 1 22  ? -54.929 -12.584 -14.126 1.00 73.53  ?  22  GLY B C   1 
ATOM   3880 O  O   . GLY B 1 22  ? -54.426 -12.521 -12.985 1.00 77.71  ?  22  GLY B O   1 
ATOM   3881 N  N   . TYR B 1 23  ? -56.243 -12.597 -14.372 1.00 73.67  ?  23  TYR B N   1 
ATOM   3882 C  CA  . TYR B 1 23  ? -57.302 -12.520 -13.331 1.00 73.24  ?  23  TYR B CA  1 
ATOM   3883 C  C   . TYR B 1 23  ? -58.142 -13.801 -13.354 1.00 72.21  ?  23  TYR B C   1 
ATOM   3884 O  O   . TYR B 1 23  ? -58.240 -14.442 -14.419 1.00 69.03  ?  23  TYR B O   1 
ATOM   3885 C  CB  . TYR B 1 23  ? -58.185 -11.288 -13.544 1.00 75.03  ?  23  TYR B CB  1 
ATOM   3886 C  CG  . TYR B 1 23  ? -57.453 -9.971  -13.488 1.00 76.44  ?  23  TYR B CG  1 
ATOM   3887 C  CD1 . TYR B 1 23  ? -56.860 -9.437  -14.621 1.00 77.06  ?  23  TYR B CD1 1 
ATOM   3888 C  CD2 . TYR B 1 23  ? -57.348 -9.258  -12.303 1.00 77.01  ?  23  TYR B CD2 1 
ATOM   3889 C  CE1 . TYR B 1 23  ? -56.177 -8.232  -14.578 1.00 78.58  ?  23  TYR B CE1 1 
ATOM   3890 C  CE2 . TYR B 1 23  ? -56.670 -8.051  -12.243 1.00 77.81  ?  23  TYR B CE2 1 
ATOM   3891 C  CZ  . TYR B 1 23  ? -56.081 -7.537  -13.385 1.00 78.22  ?  23  TYR B CZ  1 
ATOM   3892 O  OH  . TYR B 1 23  ? -55.407 -6.351  -13.340 1.00 77.14  ?  23  TYR B OH  1 
ATOM   3893 N  N   . ILE B 1 24  ? -58.722 -14.154 -12.203 1.00 72.54  ?  24  ILE B N   1 
ATOM   3894 C  CA  . ILE B 1 24  ? -59.756 -15.226 -12.067 1.00 72.16  ?  24  ILE B CA  1 
ATOM   3895 C  C   . ILE B 1 24  ? -61.094 -14.567 -11.708 1.00 72.72  ?  24  ILE B C   1 
ATOM   3896 O  O   . ILE B 1 24  ? -61.157 -13.323 -11.685 1.00 72.04  ?  24  ILE B O   1 
ATOM   3897 C  CB  . ILE B 1 24  ? -59.342 -16.297 -11.034 1.00 69.82  ?  24  ILE B CB  1 
ATOM   3898 C  CG1 . ILE B 1 24  ? -59.246 -15.734 -9.614  1.00 69.09  ?  24  ILE B CG1 1 
ATOM   3899 C  CG2 . ILE B 1 24  ? -58.058 -16.990 -11.462 1.00 69.16  ?  24  ILE B CG2 1 
ATOM   3900 C  CD1 . ILE B 1 24  ? -59.173 -16.798 -8.545  1.00 71.08  ?  24  ILE B CD1 1 
ATOM   3901 N  N   . GLN B 1 25  ? -62.124 -15.382 -11.460 1.00 73.61  ?  25  GLN B N   1 
ATOM   3902 C  CA  . GLN B 1 25  ? -63.467 -14.933 -11.011 1.00 72.85  ?  25  GLN B CA  1 
ATOM   3903 C  C   . GLN B 1 25  ? -63.540 -15.054 -9.491  1.00 72.42  ?  25  GLN B C   1 
ATOM   3904 O  O   . GLN B 1 25  ? -62.916 -15.938 -8.908  1.00 73.13  ?  25  GLN B O   1 
ATOM   3905 C  CB  . GLN B 1 25  ? -64.553 -15.754 -11.703 1.00 74.02  ?  25  GLN B CB  1 
ATOM   3906 C  CG  . GLN B 1 25  ? -64.547 -15.592 -13.215 1.00 74.44  ?  25  GLN B CG  1 
ATOM   3907 C  CD  . GLN B 1 25  ? -65.774 -16.192 -13.855 1.00 73.74  ?  25  GLN B CD  1 
ATOM   3908 O  OE1 . GLN B 1 25  ? -66.865 -16.160 -13.293 1.00 75.99  ?  25  GLN B OE1 1 
ATOM   3909 N  NE2 . GLN B 1 25  ? -65.604 -16.739 -15.046 1.00 73.35  ?  25  GLN B NE2 1 
ATOM   3910 N  N   . PRO B 1 26  ? -64.304 -14.171 -8.809  1.00 70.09  ?  26  PRO B N   1 
ATOM   3911 C  CA  . PRO B 1 26  ? -64.276 -14.094 -7.347  1.00 69.68  ?  26  PRO B CA  1 
ATOM   3912 C  C   . PRO B 1 26  ? -65.001 -15.206 -6.571  1.00 69.29  ?  26  PRO B C   1 
ATOM   3913 O  O   . PRO B 1 26  ? -64.868 -15.221 -5.363  1.00 72.69  ?  26  PRO B O   1 
ATOM   3914 C  CB  . PRO B 1 26  ? -64.977 -12.756 -7.070  1.00 69.98  ?  26  PRO B CB  1 
ATOM   3915 C  CG  . PRO B 1 26  ? -65.950 -12.607 -8.219  1.00 70.90  ?  26  PRO B CG  1 
ATOM   3916 C  CD  . PRO B 1 26  ? -65.226 -13.194 -9.412  1.00 69.53  ?  26  PRO B CD  1 
ATOM   3917 N  N   . HIS B 1 27  ? -65.728 -16.100 -7.248  1.00 69.70  ?  27  HIS B N   1 
ATOM   3918 C  CA  . HIS B 1 27  ? -66.546 -17.161 -6.590  1.00 70.61  ?  27  HIS B CA  1 
ATOM   3919 C  C   . HIS B 1 27  ? -65.651 -18.306 -6.096  1.00 69.70  ?  27  HIS B C   1 
ATOM   3920 O  O   . HIS B 1 27  ? -66.191 -19.231 -5.454  1.00 71.46  ?  27  HIS B O   1 
ATOM   3921 C  CB  . HIS B 1 27  ? -67.689 -17.635 -7.503  1.00 69.53  ?  27  HIS B CB  1 
ATOM   3922 C  CG  . HIS B 1 27  ? -67.261 -18.377 -8.723  1.00 66.71  ?  27  HIS B CG  1 
ATOM   3923 N  ND1 . HIS B 1 27  ? -66.993 -17.737 -9.917  1.00 65.99  ?  27  HIS B ND1 1 
ATOM   3924 C  CD2 . HIS B 1 27  ? -67.086 -19.697 -8.949  1.00 65.84  ?  27  HIS B CD2 1 
ATOM   3925 C  CE1 . HIS B 1 27  ? -66.658 -18.629 -10.826 1.00 68.74  ?  27  HIS B CE1 1 
ATOM   3926 N  NE2 . HIS B 1 27  ? -66.706 -19.841 -10.256 1.00 69.41  ?  27  HIS B NE2 1 
ATOM   3927 N  N   . GLY B 1 28  ? -64.345 -18.242 -6.375  1.00 68.01  ?  28  GLY B N   1 
ATOM   3928 C  CA  . GLY B 1 28  ? -63.335 -19.188 -5.860  1.00 68.71  ?  28  GLY B CA  1 
ATOM   3929 C  C   . GLY B 1 28  ? -61.943 -18.577 -5.843  1.00 68.49  ?  28  GLY B C   1 
ATOM   3930 O  O   . GLY B 1 28  ? -61.810 -17.392 -6.214  1.00 66.06  ?  28  GLY B O   1 
ATOM   3931 N  N   . CYS B 1 29  ? -60.939 -19.357 -5.430  1.00 68.97  ?  29  CYS B N   1 
ATOM   3932 C  CA  . CYS B 1 29  ? -59.515 -18.922 -5.355  1.00 72.95  ?  29  CYS B CA  1 
ATOM   3933 C  C   . CYS B 1 29  ? -58.612 -20.011 -5.946  1.00 74.28  ?  29  CYS B C   1 
ATOM   3934 O  O   . CYS B 1 29  ? -58.973 -21.203 -5.863  1.00 75.46  ?  29  CYS B O   1 
ATOM   3935 C  CB  . CYS B 1 29  ? -59.092 -18.603 -3.924  1.00 71.67  ?  29  CYS B CB  1 
ATOM   3936 S  SG  . CYS B 1 29  ? -58.910 -20.075 -2.882  1.00 72.85  ?  29  CYS B SG  1 
ATOM   3937 N  N   . LEU B 1 30  ? -57.472 -19.599 -6.505  1.00 74.90  ?  30  LEU B N   1 
ATOM   3938 C  CA  . LEU B 1 30  ? -56.549 -20.465 -7.283  1.00 73.26  ?  30  LEU B CA  1 
ATOM   3939 C  C   . LEU B 1 30  ? -55.161 -20.448 -6.638  1.00 73.54  ?  30  LEU B C   1 
ATOM   3940 O  O   . LEU B 1 30  ? -54.695 -19.357 -6.249  1.00 69.72  ?  30  LEU B O   1 
ATOM   3941 C  CB  . LEU B 1 30  ? -56.505 -19.939 -8.720  1.00 72.88  ?  30  LEU B CB  1 
ATOM   3942 C  CG  . LEU B 1 30  ? -55.766 -20.811 -9.733  1.00 72.29  ?  30  LEU B CG  1 
ATOM   3943 C  CD1 . LEU B 1 30  ? -56.388 -20.669 -11.113 1.00 72.98  ?  30  LEU B CD1 1 
ATOM   3944 C  CD2 . LEU B 1 30  ? -54.285 -20.465 -9.783  1.00 74.23  ?  30  LEU B CD2 1 
ATOM   3945 N  N   . ILE B 1 31  ? -54.540 -21.625 -6.532  1.00 74.67  ?  31  ILE B N   1 
ATOM   3946 C  CA  . ILE B 1 31  ? -53.109 -21.806 -6.148  1.00 75.70  ?  31  ILE B CA  1 
ATOM   3947 C  C   . ILE B 1 31  ? -52.412 -22.560 -7.286  1.00 74.63  ?  31  ILE B C   1 
ATOM   3948 O  O   . ILE B 1 31  ? -52.873 -23.660 -7.626  1.00 76.10  ?  31  ILE B O   1 
ATOM   3949 C  CB  . ILE B 1 31  ? -52.989 -22.542 -4.798  1.00 75.45  ?  31  ILE B CB  1 
ATOM   3950 C  CG1 . ILE B 1 31  ? -53.431 -21.647 -3.637  1.00 76.66  ?  31  ILE B CG1 1 
ATOM   3951 C  CG2 . ILE B 1 31  ? -51.579 -23.080 -4.592  1.00 75.40  ?  31  ILE B CG2 1 
ATOM   3952 C  CD1 . ILE B 1 31  ? -53.572 -22.369 -2.314  1.00 77.93  ?  31  ILE B CD1 1 
ATOM   3953 N  N   . ALA B 1 32  ? -51.356 -21.975 -7.855  1.00 73.54  ?  32  ALA B N   1 
ATOM   3954 C  CA  . ALA B 1 32  ? -50.504 -22.600 -8.892  1.00 72.81  ?  32  ALA B CA  1 
ATOM   3955 C  C   . ALA B 1 32  ? -49.214 -23.107 -8.239  1.00 73.31  ?  32  ALA B C   1 
ATOM   3956 O  O   . ALA B 1 32  ? -48.548 -22.310 -7.553  1.00 75.02  ?  32  ALA B O   1 
ATOM   3957 C  CB  . ALA B 1 32  ? -50.218 -21.619 -10.000 1.00 72.08  ?  32  ALA B CB  1 
ATOM   3958 N  N   . CYS B 1 33  ? -48.905 -24.391 -8.439  1.00 72.19  ?  33  CYS B N   1 
ATOM   3959 C  CA  . CYS B 1 33  ? -47.665 -25.068 -7.963  1.00 72.68  ?  33  CYS B CA  1 
ATOM   3960 C  C   . CYS B 1 33  ? -46.841 -25.570 -9.157  1.00 74.86  ?  33  CYS B C   1 
ATOM   3961 O  O   . CYS B 1 33  ? -47.297 -25.407 -10.306 1.00 75.81  ?  33  CYS B O   1 
ATOM   3962 C  CB  . CYS B 1 33  ? -47.997 -26.239 -7.044  1.00 72.34  ?  33  CYS B CB  1 
ATOM   3963 S  SG  . CYS B 1 33  ? -48.981 -25.771 -5.598  1.00 73.45  ?  33  CYS B SG  1 
ATOM   3964 N  N   . ASP B 1 34  ? -45.673 -26.159 -8.882  1.00 78.01  ?  34  ASP B N   1 
ATOM   3965 C  CA  . ASP B 1 34  ? -44.770 -26.776 -9.894  1.00 80.26  ?  34  ASP B CA  1 
ATOM   3966 C  C   . ASP B 1 34  ? -45.323 -28.148 -10.300 1.00 80.46  ?  34  ASP B C   1 
ATOM   3967 O  O   . ASP B 1 34  ? -46.349 -28.560 -9.724  1.00 79.24  ?  34  ASP B O   1 
ATOM   3968 C  CB  . ASP B 1 34  ? -43.342 -26.885 -9.356  1.00 83.99  ?  34  ASP B CB  1 
ATOM   3969 C  CG  . ASP B 1 34  ? -43.233 -27.685 -8.070  1.00 85.59  ?  34  ASP B CG  1 
ATOM   3970 O  OD1 . ASP B 1 34  ? -43.659 -28.855 -8.065  1.00 86.11  ?  34  ASP B OD1 1 
ATOM   3971 O  OD2 . ASP B 1 34  ? -42.741 -27.122 -7.076  1.00 91.17  ?  34  ASP B OD2 1 
ATOM   3972 N  N   . ASN B 1 35  ? -44.641 -28.831 -11.230 1.00 82.61  ?  35  ASN B N   1 
ATOM   3973 C  CA  . ASN B 1 35  ? -45.071 -30.119 -11.848 1.00 82.62  ?  35  ASN B CA  1 
ATOM   3974 C  C   . ASN B 1 35  ? -45.295 -31.193 -10.773 1.00 83.52  ?  35  ASN B C   1 
ATOM   3975 O  O   . ASN B 1 35  ? -46.209 -32.019 -10.957 1.00 87.19  ?  35  ASN B O   1 
ATOM   3976 C  CB  . ASN B 1 35  ? -44.064 -30.605 -12.896 1.00 80.95  ?  35  ASN B CB  1 
ATOM   3977 N  N   . ALA B 1 36  ? -44.495 -31.188 -9.700  1.00 84.75  ?  36  ALA B N   1 
ATOM   3978 C  CA  . ALA B 1 36  ? -44.525 -32.196 -8.610  1.00 84.74  ?  36  ALA B CA  1 
ATOM   3979 C  C   . ALA B 1 36  ? -45.484 -31.767 -7.491  1.00 83.06  ?  36  ALA B C   1 
ATOM   3980 O  O   . ALA B 1 36  ? -45.728 -32.586 -6.583  1.00 82.36  ?  36  ALA B O   1 
ATOM   3981 C  CB  . ALA B 1 36  ? -43.133 -32.410 -8.070  1.00 85.56  ?  36  ALA B CB  1 
ATOM   3982 N  N   . MET B 1 37  ? -46.005 -30.538 -7.557  1.00 82.02  ?  37  MET B N   1 
ATOM   3983 C  CA  . MET B 1 37  ? -46.846 -29.911 -6.501  1.00 84.23  ?  37  MET B CA  1 
ATOM   3984 C  C   . MET B 1 37  ? -46.060 -29.895 -5.182  1.00 85.69  ?  37  MET B C   1 
ATOM   3985 O  O   . MET B 1 37  ? -46.586 -30.367 -4.149  1.00 82.25  ?  37  MET B O   1 
ATOM   3986 C  CB  . MET B 1 37  ? -48.172 -30.659 -6.327  1.00 86.23  ?  37  MET B CB  1 
ATOM   3987 C  CG  . MET B 1 37  ? -49.277 -29.789 -5.751  1.00 88.03  ?  37  MET B CG  1 
ATOM   3988 S  SD  . MET B 1 37  ? -50.670 -30.733 -5.085  1.00 88.24  ?  37  MET B SD  1 
ATOM   3989 C  CE  . MET B 1 37  ? -50.948 -31.912 -6.406  1.00 87.04  ?  37  MET B CE  1 
ATOM   3990 N  N   . ARG B 1 38  ? -44.829 -29.378 -5.242  1.00 87.85  ?  38  ARG B N   1 
ATOM   3991 C  CA  . ARG B 1 38  ? -43.934 -29.173 -4.066  1.00 86.04  ?  38  ARG B CA  1 
ATOM   3992 C  C   . ARG B 1 38  ? -44.008 -27.703 -3.640  1.00 79.93  ?  38  ARG B C   1 
ATOM   3993 O  O   . ARG B 1 38  ? -44.344 -27.445 -2.475  1.00 79.56  ?  38  ARG B O   1 
ATOM   3994 C  CB  . ARG B 1 38  ? -42.498 -29.579 -4.420  1.00 89.75  ?  38  ARG B CB  1 
ATOM   3995 C  CG  . ARG B 1 38  ? -41.539 -29.634 -3.239  1.00 95.23  ?  38  ARG B CG  1 
ATOM   3996 C  CD  . ARG B 1 38  ? -40.091 -29.836 -3.657  1.00 98.19  ?  38  ARG B CD  1 
ATOM   3997 N  NE  . ARG B 1 38  ? -39.865 -31.111 -4.333  1.00 101.10 ?  38  ARG B NE  1 
ATOM   3998 C  CZ  . ARG B 1 38  ? -39.840 -31.298 -5.654  1.00 101.72 ?  38  ARG B CZ  1 
ATOM   3999 N  NH1 . ARG B 1 38  ? -40.027 -30.289 -6.490  1.00 101.69 ?  38  ARG B NH1 1 
ATOM   4000 N  NH2 . ARG B 1 38  ? -39.628 -32.510 -6.138  1.00 99.24  ?  38  ARG B NH2 1 
ATOM   4001 N  N   . MET B 1 39  ? -43.734 -26.788 -4.573  1.00 78.19  ?  39  MET B N   1 
ATOM   4002 C  CA  . MET B 1 39  ? -43.561 -25.332 -4.316  1.00 79.44  ?  39  MET B CA  1 
ATOM   4003 C  C   . MET B 1 39  ? -44.740 -24.545 -4.896  1.00 76.12  ?  39  MET B C   1 
ATOM   4004 O  O   . MET B 1 39  ? -45.087 -24.774 -6.071  1.00 76.64  ?  39  MET B O   1 
ATOM   4005 C  CB  . MET B 1 39  ? -42.264 -24.817 -4.952  1.00 81.19  ?  39  MET B CB  1 
ATOM   4006 C  CG  . MET B 1 39  ? -41.015 -25.464 -4.384  1.00 84.05  ?  39  MET B CG  1 
ATOM   4007 S  SD  . MET B 1 39  ? -40.724 -25.009 -2.656  1.00 86.99  ?  39  MET B SD  1 
ATOM   4008 C  CE  . MET B 1 39  ? -40.492 -23.241 -2.825  1.00 83.90  ?  39  MET B CE  1 
ATOM   4009 N  N   . VAL B 1 40  ? -45.310 -23.644 -4.092  1.00 70.76  ?  40  VAL B N   1 
ATOM   4010 C  CA  . VAL B 1 40  ? -46.352 -22.662 -4.509  1.00 68.50  ?  40  VAL B CA  1 
ATOM   4011 C  C   . VAL B 1 40  ? -45.664 -21.564 -5.327  1.00 68.07  ?  40  VAL B C   1 
ATOM   4012 O  O   . VAL B 1 40  ? -44.855 -20.827 -4.740  1.00 70.29  ?  40  VAL B O   1 
ATOM   4013 C  CB  . VAL B 1 40  ? -47.081 -22.086 -3.280  1.00 68.24  ?  40  VAL B CB  1 
ATOM   4014 C  CG1 . VAL B 1 40  ? -48.004 -20.933 -3.643  1.00 68.36  ?  40  VAL B CG1 1 
ATOM   4015 C  CG2 . VAL B 1 40  ? -47.841 -23.168 -2.529  1.00 68.25  ?  40  VAL B CG2 1 
ATOM   4016 N  N   . LEU B 1 41  ? -45.976 -21.467 -6.624  1.00 68.08  ?  41  LEU B N   1 
ATOM   4017 C  CA  . LEU B 1 41  ? -45.357 -20.497 -7.571  1.00 68.32  ?  41  LEU B CA  1 
ATOM   4018 C  C   . LEU B 1 41  ? -46.258 -19.272 -7.743  1.00 67.34  ?  41  LEU B C   1 
ATOM   4019 O  O   . LEU B 1 41  ? -45.712 -18.159 -7.888  1.00 68.39  ?  41  LEU B O   1 
ATOM   4020 C  CB  . LEU B 1 41  ? -45.122 -21.178 -8.922  1.00 69.50  ?  41  LEU B CB  1 
ATOM   4021 C  CG  . LEU B 1 41  ? -44.252 -22.433 -8.884  1.00 72.31  ?  41  LEU B CG  1 
ATOM   4022 C  CD1 . LEU B 1 41  ? -44.074 -23.007 -10.282 1.00 74.20  ?  41  LEU B CD1 1 
ATOM   4023 C  CD2 . LEU B 1 41  ? -42.900 -22.143 -8.248  1.00 72.69  ?  41  LEU B CD2 1 
ATOM   4024 N  N   . ARG B 1 42  ? -47.578 -19.477 -7.787  1.00 66.78  ?  42  ARG B N   1 
ATOM   4025 C  CA  . ARG B 1 42  ? -48.563 -18.362 -7.904  1.00 66.32  ?  42  ARG B CA  1 
ATOM   4026 C  C   . ARG B 1 42  ? -49.772 -18.640 -7.010  1.00 67.13  ?  42  ARG B C   1 
ATOM   4027 O  O   . ARG B 1 42  ? -49.970 -19.807 -6.606  1.00 66.35  ?  42  ARG B O   1 
ATOM   4028 C  CB  . ARG B 1 42  ? -49.030 -18.170 -9.350  1.00 64.98  ?  42  ARG B CB  1 
ATOM   4029 C  CG  . ARG B 1 42  ? -47.976 -18.465 -10.406 1.00 64.81  ?  42  ARG B CG  1 
ATOM   4030 C  CD  . ARG B 1 42  ? -48.076 -17.498 -11.565 1.00 64.28  ?  42  ARG B CD  1 
ATOM   4031 N  NE  . ARG B 1 42  ? -47.308 -17.920 -12.725 1.00 62.96  ?  42  ARG B NE  1 
ATOM   4032 C  CZ  . ARG B 1 42  ? -47.070 -17.156 -13.786 1.00 63.37  ?  42  ARG B CZ  1 
ATOM   4033 N  NH1 . ARG B 1 42  ? -47.535 -15.918 -13.836 1.00 64.36  ?  42  ARG B NH1 1 
ATOM   4034 N  NH2 . ARG B 1 42  ? -46.365 -17.633 -14.796 1.00 64.42  ?  42  ARG B NH2 1 
ATOM   4035 N  N   . HIS B 1 43  ? -50.534 -17.584 -6.721  1.00 68.35  ?  43  HIS B N   1 
ATOM   4036 C  CA  . HIS B 1 43  ? -51.812 -17.627 -5.963  1.00 71.35  ?  43  HIS B CA  1 
ATOM   4037 C  C   . HIS B 1 43  ? -52.635 -16.384 -6.313  1.00 70.48  ?  43  HIS B C   1 
ATOM   4038 O  O   . HIS B 1 43  ? -52.026 -15.357 -6.680  1.00 65.89  ?  43  HIS B O   1 
ATOM   4039 C  CB  . HIS B 1 43  ? -51.541 -17.753 -4.457  1.00 74.31  ?  43  HIS B CB  1 
ATOM   4040 C  CG  . HIS B 1 43  ? -51.023 -16.501 -3.830  1.00 76.32  ?  43  HIS B CG  1 
ATOM   4041 N  ND1 . HIS B 1 43  ? -49.716 -16.083 -3.986  1.00 76.55  ?  43  HIS B ND1 1 
ATOM   4042 C  CD2 . HIS B 1 43  ? -51.628 -15.576 -3.053  1.00 76.27  ?  43  HIS B CD2 1 
ATOM   4043 C  CE1 . HIS B 1 43  ? -49.538 -14.953 -3.333  1.00 77.55  ?  43  HIS B CE1 1 
ATOM   4044 N  NE2 . HIS B 1 43  ? -50.696 -14.620 -2.752  1.00 77.39  ?  43  HIS B NE2 1 
ATOM   4045 N  N   . SER B 1 44  ? -53.964 -16.499 -6.242  1.00 72.17  ?  44  SER B N   1 
ATOM   4046 C  CA  . SER B 1 44  ? -54.907 -15.356 -6.391  1.00 70.26  ?  44  SER B CA  1 
ATOM   4047 C  C   . SER B 1 44  ? -54.957 -14.576 -5.074  1.00 70.52  ?  44  SER B C   1 
ATOM   4048 O  O   . SER B 1 44  ? -54.865 -15.214 -4.006  1.00 67.32  ?  44  SER B O   1 
ATOM   4049 C  CB  . SER B 1 44  ? -56.277 -15.816 -6.817  1.00 69.70  ?  44  SER B CB  1 
ATOM   4050 O  OG  . SER B 1 44  ? -56.839 -16.693 -5.852  1.00 69.41  ?  44  SER B OG  1 
ATOM   4051 N  N   . GLU B 1 45  ? -55.107 -13.251 -5.163  1.00 75.64  ?  45  GLU B N   1 
ATOM   4052 C  CA  . GLU B 1 45  ? -55.089 -12.299 -4.014  1.00 80.52  ?  45  GLU B CA  1 
ATOM   4053 C  C   . GLU B 1 45  ? -56.027 -12.789 -2.902  1.00 81.10  ?  45  GLU B C   1 
ATOM   4054 O  O   . GLU B 1 45  ? -55.644 -12.699 -1.720  1.00 86.14  ?  45  GLU B O   1 
ATOM   4055 C  CB  . GLU B 1 45  ? -55.488 -10.900 -4.490  1.00 82.75  ?  45  GLU B CB  1 
ATOM   4056 C  CG  . GLU B 1 45  ? -54.912 -9.775  -3.650  1.00 87.45  ?  45  GLU B CG  1 
ATOM   4057 C  CD  . GLU B 1 45  ? -54.930 -8.425  -4.347  1.00 92.18  ?  45  GLU B CD  1 
ATOM   4058 O  OE1 . GLU B 1 45  ? -56.026 -7.975  -4.740  1.00 91.39  ?  45  GLU B OE1 1 
ATOM   4059 O  OE2 . GLU B 1 45  ? -53.844 -7.838  -4.516  1.00 99.81  ?  45  GLU B OE2 1 
ATOM   4060 N  N   . ASN B 1 46  ? -57.199 -13.311 -3.272  1.00 81.84  ?  46  ASN B N   1 
ATOM   4061 C  CA  . ASN B 1 46  ? -58.306 -13.644 -2.334  1.00 82.90  ?  46  ASN B CA  1 
ATOM   4062 C  C   . ASN B 1 46  ? -58.090 -15.023 -1.693  1.00 81.80  ?  46  ASN B C   1 
ATOM   4063 O  O   . ASN B 1 46  ? -59.006 -15.474 -0.975  1.00 82.25  ?  46  ASN B O   1 
ATOM   4064 C  CB  . ASN B 1 46  ? -59.671 -13.551 -3.027  1.00 84.06  ?  46  ASN B CB  1 
ATOM   4065 C  CG  . ASN B 1 46  ? -59.854 -14.534 -4.166  1.00 85.20  ?  46  ASN B CG  1 
ATOM   4066 O  OD1 . ASN B 1 46  ? -58.896 -15.146 -4.638  1.00 82.20  ?  46  ASN B OD1 1 
ATOM   4067 N  ND2 . ASN B 1 46  ? -61.085 -14.683 -4.627  1.00 86.51  ?  46  ASN B ND2 1 
ATOM   4068 N  N   . CYS B 1 47  ? -56.944 -15.672 -1.928  1.00 79.21  ?  47  CYS B N   1 
ATOM   4069 C  CA  . CYS B 1 47  ? -56.604 -16.987 -1.307  1.00 82.63  ?  47  CYS B CA  1 
ATOM   4070 C  C   . CYS B 1 47  ? -56.671 -16.860 0.219   1.00 87.02  ?  47  CYS B C   1 
ATOM   4071 O  O   . CYS B 1 47  ? -57.253 -17.757 0.858   1.00 89.43  ?  47  CYS B O   1 
ATOM   4072 C  CB  . CYS B 1 47  ? -55.230 -17.493 -1.727  1.00 81.22  ?  47  CYS B CB  1 
ATOM   4073 S  SG  . CYS B 1 47  ? -55.202 -18.197 -3.396  1.00 80.45  ?  47  CYS B SG  1 
ATOM   4074 N  N   . GLY B 1 48  ? -56.109 -15.776 0.765   1.00 90.53  ?  48  GLY B N   1 
ATOM   4075 C  CA  . GLY B 1 48  ? -56.132 -15.466 2.208   1.00 90.45  ?  48  GLY B CA  1 
ATOM   4076 C  C   . GLY B 1 48  ? -57.553 -15.401 2.739   1.00 91.77  ?  48  GLY B C   1 
ATOM   4077 O  O   . GLY B 1 48  ? -57.901 -16.230 3.604   1.00 89.40  ?  48  GLY B O   1 
ATOM   4078 N  N   . GLU B 1 49  ? -58.345 -14.461 2.217   1.00 93.04  ?  49  GLU B N   1 
ATOM   4079 C  CA  . GLU B 1 49  ? -59.773 -14.243 2.581   1.00 98.19  ?  49  GLU B CA  1 
ATOM   4080 C  C   . GLU B 1 49  ? -60.530 -15.582 2.598   1.00 98.49  ?  49  GLU B C   1 
ATOM   4081 O  O   . GLU B 1 49  ? -61.220 -15.852 3.599   1.00 100.47 ?  49  GLU B O   1 
ATOM   4082 C  CB  . GLU B 1 49  ? -60.396 -13.249 1.597   1.00 102.18 ?  49  GLU B CB  1 
ATOM   4083 C  CG  . GLU B 1 49  ? -61.830 -12.864 1.917   1.00 107.08 ?  49  GLU B CG  1 
ATOM   4084 C  CD  . GLU B 1 49  ? -62.478 -11.974 0.868   1.00 112.58 ?  49  GLU B CD  1 
ATOM   4085 O  OE1 . GLU B 1 49  ? -63.724 -11.939 0.813   1.00 116.48 ?  49  GLU B OE1 1 
ATOM   4086 O  OE2 . GLU B 1 49  ? -61.736 -11.320 0.105   1.00 115.52 ?  49  GLU B OE2 1 
ATOM   4087 N  N   . LEU B 1 50  ? -60.393 -16.395 1.544   1.00 97.60  ?  50  LEU B N   1 
ATOM   4088 C  CA  . LEU B 1 50  ? -61.225 -17.611 1.310   1.00 97.42  ?  50  LEU B CA  1 
ATOM   4089 C  C   . LEU B 1 50  ? -60.717 -18.792 2.151   1.00 97.36  ?  50  LEU B C   1 
ATOM   4090 O  O   . LEU B 1 50  ? -61.566 -19.498 2.728   1.00 93.11  ?  50  LEU B O   1 
ATOM   4091 C  CB  . LEU B 1 50  ? -61.215 -17.952 -0.184  1.00 97.17  ?  50  LEU B CB  1 
ATOM   4092 N  N   . LEU B 1 51  ? -59.396 -19.005 2.214   1.00 99.30  ?  51  LEU B N   1 
ATOM   4093 C  CA  . LEU B 1 51  ? -58.772 -20.199 2.857   1.00 100.42 ?  51  LEU B CA  1 
ATOM   4094 C  C   . LEU B 1 51  ? -58.355 -19.896 4.303   1.00 103.15 ?  51  LEU B C   1 
ATOM   4095 O  O   . LEU B 1 51  ? -58.224 -20.863 5.081   1.00 103.42 ?  51  LEU B O   1 
ATOM   4096 C  CB  . LEU B 1 51  ? -57.563 -20.652 2.032   1.00 99.50  ?  51  LEU B CB  1 
ATOM   4097 C  CG  . LEU B 1 51  ? -57.888 -21.295 0.684   1.00 99.75  ?  51  LEU B CG  1 
ATOM   4098 C  CD1 . LEU B 1 51  ? -56.644 -21.385 -0.186  1.00 99.75  ?  51  LEU B CD1 1 
ATOM   4099 C  CD2 . LEU B 1 51  ? -58.508 -22.672 0.871   1.00 100.53 ?  51  LEU B CD2 1 
ATOM   4100 N  N   . GLY B 1 52  ? -58.138 -18.621 4.644   1.00 105.28 ?  52  GLY B N   1 
ATOM   4101 C  CA  . GLY B 1 52  ? -57.718 -18.187 5.992   1.00 107.04 ?  52  GLY B CA  1 
ATOM   4102 C  C   . GLY B 1 52  ? -56.220 -18.350 6.189   1.00 109.24 ?  52  GLY B C   1 
ATOM   4103 O  O   . GLY B 1 52  ? -55.817 -19.062 7.134   1.00 111.17 ?  52  GLY B O   1 
ATOM   4104 N  N   . LEU B 1 53  ? -55.431 -17.711 5.320   1.00 107.58 ?  53  LEU B N   1 
ATOM   4105 C  CA  . LEU B 1 53  ? -53.943 -17.733 5.338   1.00 108.17 ?  53  LEU B CA  1 
ATOM   4106 C  C   . LEU B 1 53  ? -53.425 -16.292 5.262   1.00 110.55 ?  53  LEU B C   1 
ATOM   4107 O  O   . LEU B 1 53  ? -53.876 -15.550 4.371   1.00 110.78 ?  53  LEU B O   1 
ATOM   4108 C  CB  . LEU B 1 53  ? -53.438 -18.569 4.156   1.00 106.15 ?  53  LEU B CB  1 
ATOM   4109 C  CG  . LEU B 1 53  ? -54.003 -19.987 4.047   1.00 104.39 ?  53  LEU B CG  1 
ATOM   4110 C  CD1 . LEU B 1 53  ? -53.570 -20.636 2.743   1.00 102.59 ?  53  LEU B CD1 1 
ATOM   4111 C  CD2 . LEU B 1 53  ? -53.583 -20.848 5.231   1.00 102.81 ?  53  LEU B CD2 1 
ATOM   4112 N  N   . GLU B 1 54  ? -52.516 -15.916 6.167   1.00 112.98 ?  54  GLU B N   1 
ATOM   4113 C  CA  . GLU B 1 54  ? -51.976 -14.533 6.289   1.00 114.26 ?  54  GLU B CA  1 
ATOM   4114 C  C   . GLU B 1 54  ? -50.756 -14.374 5.371   1.00 112.68 ?  54  GLU B C   1 
ATOM   4115 O  O   . GLU B 1 54  ? -49.996 -15.351 5.219   1.00 109.25 ?  54  GLU B O   1 
ATOM   4116 C  CB  . GLU B 1 54  ? -51.621 -14.232 7.748   1.00 113.00 ?  54  GLU B CB  1 
ATOM   4117 N  N   . GLY B 1 55  ? -50.594 -13.187 4.773   1.00 112.44 ?  55  GLY B N   1 
ATOM   4118 C  CA  . GLY B 1 55  ? -49.382 -12.776 4.035   1.00 112.40 ?  55  GLY B CA  1 
ATOM   4119 C  C   . GLY B 1 55  ? -49.306 -13.378 2.641   1.00 111.77 ?  55  GLY B C   1 
ATOM   4120 O  O   . GLY B 1 55  ? -50.371 -13.607 2.034   1.00 111.94 ?  55  GLY B O   1 
ATOM   4121 N  N   . ASP B 1 56  ? -48.080 -13.622 2.158   1.00 110.32 ?  56  ASP B N   1 
ATOM   4122 C  CA  . ASP B 1 56  ? -47.766 -14.116 0.788   1.00 104.15 ?  56  ASP B CA  1 
ATOM   4123 C  C   . ASP B 1 56  ? -47.521 -15.631 0.840   1.00 98.46  ?  56  ASP B C   1 
ATOM   4124 O  O   . ASP B 1 56  ? -46.879 -16.098 1.804   1.00 91.45  ?  56  ASP B O   1 
ATOM   4125 C  CB  . ASP B 1 56  ? -46.564 -13.368 0.203   1.00 105.28 ?  56  ASP B CB  1 
ATOM   4126 C  CG  . ASP B 1 56  ? -46.363 -13.566 -1.290  1.00 107.27 ?  56  ASP B CG  1 
ATOM   4127 O  OD1 . ASP B 1 56  ? -46.451 -14.722 -1.750  1.00 110.15 ?  56  ASP B OD1 1 
ATOM   4128 O  OD2 . ASP B 1 56  ? -46.116 -12.561 -1.982  1.00 108.96 ?  56  ASP B OD2 1 
ATOM   4129 N  N   . LEU B 1 57  ? -48.016 -16.352 -0.173  1.00 94.36  ?  57  LEU B N   1 
ATOM   4130 C  CA  . LEU B 1 57  ? -47.989 -17.840 -0.269  1.00 90.27  ?  57  LEU B CA  1 
ATOM   4131 C  C   . LEU B 1 57  ? -46.826 -18.288 -1.159  1.00 83.60  ?  57  LEU B C   1 
ATOM   4132 O  O   . LEU B 1 57  ? -46.370 -19.434 -0.994  1.00 80.59  ?  57  LEU B O   1 
ATOM   4133 C  CB  . LEU B 1 57  ? -49.318 -18.338 -0.849  1.00 93.90  ?  57  LEU B CB  1 
ATOM   4134 C  CG  . LEU B 1 57  ? -50.525 -18.283 0.086   1.00 95.54  ?  57  LEU B CG  1 
ATOM   4135 C  CD1 . LEU B 1 57  ? -50.997 -16.851 0.296   1.00 97.24  ?  57  LEU B CD1 1 
ATOM   4136 C  CD2 . LEU B 1 57  ? -51.661 -19.135 -0.456  1.00 96.11  ?  57  LEU B CD2 1 
ATOM   4137 N  N   . ASN B 1 58  ? -46.386 -17.425 -2.079  1.00 82.12  ?  58  ASN B N   1 
ATOM   4138 C  CA  . ASN B 1 58  ? -45.379 -17.751 -3.125  1.00 83.40  ?  58  ASN B CA  1 
ATOM   4139 C  C   . ASN B 1 58  ? -44.016 -17.995 -2.467  1.00 84.71  ?  58  ASN B C   1 
ATOM   4140 O  O   . ASN B 1 58  ? -43.637 -17.206 -1.578  1.00 89.74  ?  58  ASN B O   1 
ATOM   4141 C  CB  . ASN B 1 58  ? -45.304 -16.656 -4.191  1.00 82.27  ?  58  ASN B CB  1 
ATOM   4142 C  CG  . ASN B 1 58  ? -46.610 -16.468 -4.935  1.00 80.86  ?  58  ASN B CG  1 
ATOM   4143 O  OD1 . ASN B 1 58  ? -47.422 -17.387 -5.021  1.00 83.21  ?  58  ASN B OD1 1 
ATOM   4144 N  ND2 . ASN B 1 58  ? -46.825 -15.282 -5.476  1.00 80.24  ?  58  ASN B ND2 1 
ATOM   4145 N  N   . GLY B 1 59  ? -43.325 -19.059 -2.888  1.00 82.73  ?  59  GLY B N   1 
ATOM   4146 C  CA  . GLY B 1 59  ? -42.004 -19.460 -2.365  1.00 83.02  ?  59  GLY B CA  1 
ATOM   4147 C  C   . GLY B 1 59  ? -42.114 -20.456 -1.221  1.00 84.24  ?  59  GLY B C   1 
ATOM   4148 O  O   . GLY B 1 59  ? -41.083 -21.054 -0.872  1.00 86.90  ?  59  GLY B O   1 
ATOM   4149 N  N   . ARG B 1 60  ? -43.306 -20.619 -0.641  1.00 84.65  ?  60  ARG B N   1 
ATOM   4150 C  CA  . ARG B 1 60  ? -43.572 -21.613 0.438   1.00 87.81  ?  60  ARG B CA  1 
ATOM   4151 C  C   . ARG B 1 60  ? -43.913 -22.962 -0.204  1.00 86.49  ?  60  ARG B C   1 
ATOM   4152 O  O   . ARG B 1 60  ? -44.238 -22.972 -1.408  1.00 87.33  ?  60  ARG B O   1 
ATOM   4153 C  CB  . ARG B 1 60  ? -44.686 -21.103 1.355   1.00 88.55  ?  60  ARG B CB  1 
ATOM   4154 C  CG  . ARG B 1 60  ? -44.379 -19.749 1.979   1.00 90.03  ?  60  ARG B CG  1 
ATOM   4155 C  CD  . ARG B 1 60  ? -45.567 -19.119 2.676   1.00 91.86  ?  60  ARG B CD  1 
ATOM   4156 N  NE  . ARG B 1 60  ? -46.113 -19.961 3.731   1.00 93.77  ?  60  ARG B NE  1 
ATOM   4157 C  CZ  . ARG B 1 60  ? -47.111 -19.614 4.540   1.00 95.20  ?  60  ARG B CZ  1 
ATOM   4158 N  NH1 . ARG B 1 60  ? -47.688 -18.428 4.423   1.00 92.99  ?  60  ARG B NH1 1 
ATOM   4159 N  NH2 . ARG B 1 60  ? -47.529 -20.460 5.466   1.00 95.99  ?  60  ARG B NH2 1 
ATOM   4160 N  N   . THR B 1 61  ? -43.828 -24.055 0.563   1.00 84.51  ?  61  THR B N   1 
ATOM   4161 C  CA  . THR B 1 61  ? -44.139 -25.430 0.077   1.00 85.19  ?  61  THR B CA  1 
ATOM   4162 C  C   . THR B 1 61  ? -45.657 -25.629 0.114   1.00 87.91  ?  61  THR B C   1 
ATOM   4163 O  O   . THR B 1 61  ? -46.322 -24.948 0.918   1.00 90.81  ?  61  THR B O   1 
ATOM   4164 C  CB  . THR B 1 61  ? -43.422 -26.522 0.885   1.00 84.15  ?  61  THR B CB  1 
ATOM   4165 O  OG1 . THR B 1 61  ? -44.004 -26.604 2.186   1.00 83.57  ?  61  THR B OG1 1 
ATOM   4166 C  CG2 . THR B 1 61  ? -41.935 -26.280 1.011   1.00 85.07  ?  61  THR B CG2 1 
ATOM   4167 N  N   . ALA B 1 62  ? -46.176 -26.524 -0.729  1.00 89.09  ?  62  ALA B N   1 
ATOM   4168 C  CA  . ALA B 1 62  ? -47.603 -26.923 -0.759  1.00 90.39  ?  62  ALA B CA  1 
ATOM   4169 C  C   . ALA B 1 62  ? -48.013 -27.413 0.635   1.00 90.27  ?  62  ALA B C   1 
ATOM   4170 O  O   . ALA B 1 62  ? -49.041 -26.932 1.150   1.00 93.33  ?  62  ALA B O   1 
ATOM   4171 C  CB  . ALA B 1 62  ? -47.828 -27.983 -1.810  1.00 92.58  ?  62  ALA B CB  1 
ATOM   4172 N  N   . GLU B 1 63  ? -47.217 -28.314 1.220   1.00 89.08  ?  63  GLU B N   1 
ATOM   4173 C  CA  . GLU B 1 63  ? -47.451 -28.901 2.569   1.00 91.27  ?  63  GLU B CA  1 
ATOM   4174 C  C   . GLU B 1 63  ? -47.556 -27.783 3.616   1.00 90.27  ?  63  GLU B C   1 
ATOM   4175 O  O   . GLU B 1 63  ? -48.461 -27.864 4.467   1.00 90.28  ?  63  GLU B O   1 
ATOM   4176 C  CB  . GLU B 1 63  ? -46.343 -29.895 2.926   1.00 95.05  ?  63  GLU B CB  1 
ATOM   4177 C  CG  . GLU B 1 63  ? -46.446 -31.212 2.174   1.00 98.32  ?  63  GLU B CG  1 
ATOM   4178 C  CD  . GLU B 1 63  ? -45.411 -32.260 2.551   1.00 101.24 ?  63  GLU B CD  1 
ATOM   4179 O  OE1 . GLU B 1 63  ? -44.698 -32.057 3.556   1.00 103.13 ?  63  GLU B OE1 1 
ATOM   4180 O  OE2 . GLU B 1 63  ? -45.319 -33.281 1.837   1.00 101.36 ?  63  GLU B OE2 1 
ATOM   4181 N  N   . ASP B 1 64  ? -46.680 -26.776 3.551   1.00 89.92  ?  64  ASP B N   1 
ATOM   4182 C  CA  . ASP B 1 64  ? -46.635 -25.650 4.526   1.00 91.97  ?  64  ASP B CA  1 
ATOM   4183 C  C   . ASP B 1 64  ? -47.959 -24.872 4.482   1.00 94.71  ?  64  ASP B C   1 
ATOM   4184 O  O   . ASP B 1 64  ? -48.405 -24.412 5.552   1.00 94.92  ?  64  ASP B O   1 
ATOM   4185 C  CB  . ASP B 1 64  ? -45.445 -24.721 4.264   1.00 89.78  ?  64  ASP B CB  1 
ATOM   4186 C  CG  . ASP B 1 64  ? -45.287 -23.611 5.291   1.00 88.13  ?  64  ASP B CG  1 
ATOM   4187 O  OD1 . ASP B 1 64  ? -44.826 -23.910 6.411   1.00 90.46  ?  64  ASP B OD1 1 
ATOM   4188 O  OD2 . ASP B 1 64  ? -45.634 -22.457 4.966   1.00 80.89  ?  64  ASP B OD2 1 
ATOM   4189 N  N   . VAL B 1 65  ? -48.558 -24.735 3.294   1.00 96.58  ?  65  VAL B N   1 
ATOM   4190 C  CA  . VAL B 1 65  ? -49.725 -23.837 3.029   1.00 96.20  ?  65  VAL B CA  1 
ATOM   4191 C  C   . VAL B 1 65  ? -51.034 -24.600 3.281   1.00 94.79  ?  65  VAL B C   1 
ATOM   4192 O  O   . VAL B 1 65  ? -51.953 -24.005 3.885   1.00 93.60  ?  65  VAL B O   1 
ATOM   4193 C  CB  . VAL B 1 65  ? -49.658 -23.259 1.600   1.00 97.08  ?  65  VAL B CB  1 
ATOM   4194 C  CG1 . VAL B 1 65  ? -50.870 -22.406 1.261   1.00 98.50  ?  65  VAL B CG1 1 
ATOM   4195 C  CG2 . VAL B 1 65  ? -48.386 -22.455 1.379   1.00 98.43  ?  65  VAL B CG2 1 
ATOM   4196 N  N   . LEU B 1 66  ? -51.113 -25.860 2.840   1.00 93.65  ?  66  LEU B N   1 
ATOM   4197 C  CA  . LEU B 1 66  ? -52.369 -26.664 2.811   1.00 94.69  ?  66  LEU B CA  1 
ATOM   4198 C  C   . LEU B 1 66  ? -52.365 -27.755 3.892   1.00 95.16  ?  66  LEU B C   1 
ATOM   4199 O  O   . LEU B 1 66  ? -53.469 -28.130 4.339   1.00 97.61  ?  66  LEU B O   1 
ATOM   4200 C  CB  . LEU B 1 66  ? -52.524 -27.283 1.418   1.00 94.01  ?  66  LEU B CB  1 
ATOM   4201 C  CG  . LEU B 1 66  ? -52.572 -26.295 0.253   1.00 93.11  ?  66  LEU B CG  1 
ATOM   4202 C  CD1 . LEU B 1 66  ? -52.661 -27.032 -1.074  1.00 93.26  ?  66  LEU B CD1 1 
ATOM   4203 C  CD2 . LEU B 1 66  ? -53.733 -25.322 0.398   1.00 92.10  ?  66  LEU B CD2 1 
ATOM   4204 N  N   . GLY B 1 67  ? -51.185 -28.255 4.278   1.00 93.31  ?  67  GLY B N   1 
ATOM   4205 C  CA  . GLY B 1 67  ? -51.023 -29.388 5.214   1.00 91.96  ?  67  GLY B CA  1 
ATOM   4206 C  C   . GLY B 1 67  ? -50.705 -30.678 4.477   1.00 90.74  ?  67  GLY B C   1 
ATOM   4207 O  O   . GLY B 1 67  ? -51.123 -30.804 3.311   1.00 87.77  ?  67  GLY B O   1 
ATOM   4208 N  N   . LYS B 1 68  ? -49.997 -31.603 5.136   1.00 92.88  ?  68  LYS B N   1 
ATOM   4209 C  CA  . LYS B 1 68  ? -49.493 -32.876 4.544   1.00 93.65  ?  68  LYS B CA  1 
ATOM   4210 C  C   . LYS B 1 68  ? -50.670 -33.760 4.109   1.00 94.36  ?  68  LYS B C   1 
ATOM   4211 O  O   . LYS B 1 68  ? -50.541 -34.420 3.058   1.00 94.47  ?  68  LYS B O   1 
ATOM   4212 C  CB  . LYS B 1 68  ? -48.601 -33.622 5.543   1.00 91.54  ?  68  LYS B CB  1 
ATOM   4213 N  N   . ARG B 1 69  ? -51.764 -33.765 4.883   1.00 97.81  ?  69  ARG B N   1 
ATOM   4214 C  CA  . ARG B 1 69  ? -52.965 -34.625 4.659   1.00 98.16  ?  69  ARG B CA  1 
ATOM   4215 C  C   . ARG B 1 69  ? -53.565 -34.340 3.275   1.00 97.64  ?  69  ARG B C   1 
ATOM   4216 O  O   . ARG B 1 69  ? -53.650 -35.286 2.460   1.00 95.13  ?  69  ARG B O   1 
ATOM   4217 C  CB  . ARG B 1 69  ? -54.017 -34.380 5.746   1.00 95.93  ?  69  ARG B CB  1 
ATOM   4218 N  N   . LEU B 1 70  ? -53.966 -33.086 3.036   1.00 95.32  ?  70  LEU B N   1 
ATOM   4219 C  CA  . LEU B 1 70  ? -54.642 -32.625 1.790   1.00 94.39  ?  70  LEU B CA  1 
ATOM   4220 C  C   . LEU B 1 70  ? -53.725 -32.859 0.584   1.00 96.99  ?  70  LEU B C   1 
ATOM   4221 O  O   . LEU B 1 70  ? -54.176 -33.503 -0.382  1.00 102.46 ?  70  LEU B O   1 
ATOM   4222 C  CB  . LEU B 1 70  ? -55.006 -31.143 1.934   1.00 91.85  ?  70  LEU B CB  1 
ATOM   4223 C  CG  . LEU B 1 70  ? -55.694 -30.496 0.731   1.00 90.95  ?  70  LEU B CG  1 
ATOM   4224 C  CD1 . LEU B 1 70  ? -56.827 -31.363 0.203   1.00 91.05  ?  70  LEU B CD1 1 
ATOM   4225 C  CD2 . LEU B 1 70  ? -56.214 -29.113 1.089   1.00 90.20  ?  70  LEU B CD2 1 
ATOM   4226 N  N   . VAL B 1 71  ? -52.484 -32.369 0.656   1.00 98.00  ?  71  VAL B N   1 
ATOM   4227 C  CA  . VAL B 1 71  ? -51.473 -32.443 -0.443  1.00 99.85  ?  71  VAL B CA  1 
ATOM   4228 C  C   . VAL B 1 71  ? -51.297 -33.906 -0.866  1.00 99.11  ?  71  VAL B C   1 
ATOM   4229 O  O   . VAL B 1 71  ? -51.200 -34.155 -2.080  1.00 99.19  ?  71  VAL B O   1 
ATOM   4230 C  CB  . VAL B 1 71  ? -50.132 -31.810 -0.026  1.00 103.38 ?  71  VAL B CB  1 
ATOM   4231 C  CG1 . VAL B 1 71  ? -49.009 -32.151 -0.997  1.00 104.73 ?  71  VAL B CG1 1 
ATOM   4232 C  CG2 . VAL B 1 71  ? -50.253 -30.301 0.134   1.00 104.79 ?  71  VAL B CG2 1 
ATOM   4233 N  N   . HIS B 1 72  ? -51.248 -34.830 0.097   1.00 102.92 ?  72  HIS B N   1 
ATOM   4234 C  CA  . HIS B 1 72  ? -51.143 -36.293 -0.158  1.00 108.74 ?  72  HIS B CA  1 
ATOM   4235 C  C   . HIS B 1 72  ? -52.283 -36.716 -1.093  1.00 106.86 ?  72  HIS B C   1 
ATOM   4236 O  O   . HIS B 1 72  ? -51.983 -37.288 -2.161  1.00 103.27 ?  72  HIS B O   1 
ATOM   4237 C  CB  . HIS B 1 72  ? -51.132 -37.087 1.158   1.00 114.59 ?  72  HIS B CB  1 
ATOM   4238 C  CG  . HIS B 1 72  ? -50.870 -38.547 0.981   1.00 120.01 ?  72  HIS B CG  1 
ATOM   4239 N  ND1 . HIS B 1 72  ? -51.881 -39.490 1.023   1.00 121.31 ?  72  HIS B ND1 1 
ATOM   4240 C  CD2 . HIS B 1 72  ? -49.725 -39.230 0.759   1.00 122.85 ?  72  HIS B CD2 1 
ATOM   4241 C  CE1 . HIS B 1 72  ? -51.368 -40.690 0.836   1.00 121.54 ?  72  HIS B CE1 1 
ATOM   4242 N  NE2 . HIS B 1 72  ? -50.047 -40.558 0.671   1.00 122.77 ?  72  HIS B NE2 1 
ATOM   4243 N  N   . ASP B 1 73  ? -53.529 -36.411 -0.711  1.00 106.48 ?  73  ASP B N   1 
ATOM   4244 C  CA  . ASP B 1 73  ? -54.768 -36.789 -1.450  1.00 106.07 ?  73  ASP B CA  1 
ATOM   4245 C  C   . ASP B 1 73  ? -54.746 -36.168 -2.854  1.00 103.69 ?  73  ASP B C   1 
ATOM   4246 O  O   . ASP B 1 73  ? -55.112 -36.875 -3.816  1.00 102.40 ?  73  ASP B O   1 
ATOM   4247 C  CB  . ASP B 1 73  ? -56.029 -36.387 -0.677  1.00 106.34 ?  73  ASP B CB  1 
ATOM   4248 C  CG  . ASP B 1 73  ? -56.370 -37.295 0.497   1.00 106.95 ?  73  ASP B CG  1 
ATOM   4249 O  OD1 . ASP B 1 73  ? -56.243 -38.532 0.346   1.00 101.65 ?  73  ASP B OD1 1 
ATOM   4250 O  OD2 . ASP B 1 73  ? -56.769 -36.761 1.554   1.00 103.03 ?  73  ASP B OD2 1 
ATOM   4251 N  N   . LEU B 1 74  ? -54.324 -34.904 -2.964  1.00 103.46 ?  74  LEU B N   1 
ATOM   4252 C  CA  . LEU B 1 74  ? -54.232 -34.156 -4.250  1.00 102.37 ?  74  LEU B CA  1 
ATOM   4253 C  C   . LEU B 1 74  ? -53.204 -34.816 -5.179  1.00 104.54 ?  74  LEU B C   1 
ATOM   4254 O  O   . LEU B 1 74  ? -53.504 -34.935 -6.382  1.00 108.10 ?  74  LEU B O   1 
ATOM   4255 C  CB  . LEU B 1 74  ? -53.850 -32.700 -3.968  1.00 102.29 ?  74  LEU B CB  1 
ATOM   4256 C  CG  . LEU B 1 74  ? -54.909 -31.857 -3.261  1.00 103.00 ?  74  LEU B CG  1 
ATOM   4257 C  CD1 . LEU B 1 74  ? -54.377 -30.461 -2.974  1.00 102.81 ?  74  LEU B CD1 1 
ATOM   4258 C  CD2 . LEU B 1 74  ? -56.190 -31.780 -4.079  1.00 103.60 ?  74  LEU B CD2 1 
ATOM   4259 N  N   . ARG B 1 75  ? -52.043 -35.223 -4.650  1.00 105.91 ?  75  ARG B N   1 
ATOM   4260 C  CA  . ARG B 1 75  ? -50.956 -35.856 -5.454  1.00 104.62 ?  75  ARG B CA  1 
ATOM   4261 C  C   . ARG B 1 75  ? -51.452 -37.192 -6.018  1.00 105.94 ?  75  ARG B C   1 
ATOM   4262 O  O   . ARG B 1 75  ? -51.089 -37.510 -7.165  1.00 107.48 ?  75  ARG B O   1 
ATOM   4263 C  CB  . ARG B 1 75  ? -49.689 -36.067 -4.618  1.00 105.56 ?  75  ARG B CB  1 
ATOM   4264 C  CG  . ARG B 1 75  ? -48.924 -34.788 -4.310  1.00 106.69 ?  75  ARG B CG  1 
ATOM   4265 C  CD  . ARG B 1 75  ? -47.431 -34.919 -4.543  1.00 106.97 ?  75  ARG B CD  1 
ATOM   4266 N  NE  . ARG B 1 75  ? -46.711 -33.731 -4.099  1.00 108.10 ?  75  ARG B NE  1 
ATOM   4267 C  CZ  . ARG B 1 75  ? -46.352 -33.472 -2.842  1.00 107.06 ?  75  ARG B CZ  1 
ATOM   4268 N  NH1 . ARG B 1 75  ? -46.637 -34.321 -1.869  1.00 108.33 ?  75  ARG B NH1 1 
ATOM   4269 N  NH2 . ARG B 1 75  ? -45.703 -32.356 -2.559  1.00 108.40 ?  75  ARG B NH2 1 
ATOM   4270 N  N   . ASN B 1 76  ? -52.251 -37.933 -5.240  1.00 109.10 ?  76  ASN B N   1 
ATOM   4271 C  CA  . ASN B 1 76  ? -52.818 -39.255 -5.625  1.00 112.83 ?  76  ASN B CA  1 
ATOM   4272 C  C   . ASN B 1 76  ? -53.792 -39.085 -6.798  1.00 111.26 ?  76  ASN B C   1 
ATOM   4273 O  O   . ASN B 1 76  ? -53.752 -39.924 -7.721  1.00 111.71 ?  76  ASN B O   1 
ATOM   4274 C  CB  . ASN B 1 76  ? -53.507 -39.945 -4.444  1.00 116.26 ?  76  ASN B CB  1 
ATOM   4275 C  CG  . ASN B 1 76  ? -52.533 -40.456 -3.402  1.00 118.93 ?  76  ASN B CG  1 
ATOM   4276 O  OD1 . ASN B 1 76  ? -52.634 -40.106 -2.229  1.00 123.68 ?  76  ASN B OD1 1 
ATOM   4277 N  ND2 . ASN B 1 76  ? -51.588 -41.285 -3.816  1.00 118.72 ?  76  ASN B ND2 1 
ATOM   4278 N  N   . ALA B 1 77  ? -54.621 -38.037 -6.757  1.00 108.79 ?  77  ALA B N   1 
ATOM   4279 C  CA  . ALA B 1 77  ? -55.696 -37.744 -7.739  1.00 109.11 ?  77  ALA B CA  1 
ATOM   4280 C  C   . ALA B 1 77  ? -55.115 -37.458 -9.133  1.00 111.67 ?  77  ALA B C   1 
ATOM   4281 O  O   . ALA B 1 77  ? -55.845 -37.677 -10.121 1.00 112.10 ?  77  ALA B O   1 
ATOM   4282 C  CB  . ALA B 1 77  ? -56.532 -36.588 -7.249  1.00 107.29 ?  77  ALA B CB  1 
ATOM   4283 N  N   . LEU B 1 78  ? -53.870 -36.975 -9.213  1.00 114.69 ?  78  LEU B N   1 
ATOM   4284 C  CA  . LEU B 1 78  ? -53.170 -36.681 -10.498 1.00 118.05 ?  78  LEU B CA  1 
ATOM   4285 C  C   . LEU B 1 78  ? -52.683 -37.984 -11.145 1.00 120.23 ?  78  LEU B C   1 
ATOM   4286 O  O   . LEU B 1 78  ? -52.619 -38.024 -12.390 1.00 119.55 ?  78  LEU B O   1 
ATOM   4287 C  CB  . LEU B 1 78  ? -51.996 -35.726 -10.252 1.00 119.89 ?  78  LEU B CB  1 
ATOM   4288 C  CG  . LEU B 1 78  ? -52.368 -34.257 -10.054 1.00 122.00 ?  78  LEU B CG  1 
ATOM   4289 C  CD1 . LEU B 1 78  ? -51.159 -33.453 -9.599  1.00 123.65 ?  78  LEU B CD1 1 
ATOM   4290 C  CD2 . LEU B 1 78  ? -52.957 -33.655 -11.323 1.00 120.44 ?  78  LEU B CD2 1 
ATOM   4291 N  N   . THR B 1 79  ? -52.341 -38.998 -10.341 1.00 123.98 ?  79  THR B N   1 
ATOM   4292 C  CA  . THR B 1 79  ? -51.915 -40.345 -10.821 1.00 124.53 ?  79  THR B CA  1 
ATOM   4293 C  C   . THR B 1 79  ? -53.102 -41.040 -11.505 1.00 128.41 ?  79  THR B C   1 
ATOM   4294 O  O   . THR B 1 79  ? -53.634 -42.007 -10.922 1.00 128.86 ?  79  THR B O   1 
ATOM   4295 C  CB  . THR B 1 79  ? -51.341 -41.184 -9.671  1.00 116.81 ?  79  THR B CB  1 
ATOM   4296 N  N   . VAL B 1 80  ? -53.494 -40.553 -12.690 1.00 132.55 ?  80  VAL B N   1 
ATOM   4297 C  CA  . VAL B 1 80  ? -54.638 -41.069 -13.508 1.00 132.77 ?  80  VAL B CA  1 
ATOM   4298 C  C   . VAL B 1 80  ? -54.327 -40.851 -14.996 1.00 130.09 ?  80  VAL B C   1 
ATOM   4299 O  O   . VAL B 1 80  ? -53.740 -39.795 -15.316 1.00 123.81 ?  80  VAL B O   1 
ATOM   4300 C  CB  . VAL B 1 80  ? -55.980 -40.415 -13.112 1.00 130.89 ?  80  VAL B CB  1 
ATOM   4301 C  CG1 . VAL B 1 80  ? -56.478 -40.906 -11.760 1.00 125.32 ?  80  VAL B CG1 1 
ATOM   4302 C  CG2 . VAL B 1 80  ? -55.917 -38.892 -13.142 1.00 129.93 ?  80  VAL B CG2 1 
ATOM   4303 N  N   . THR B 1 85  ? -54.627 -34.225 -18.905 1.00 119.45 ?  85  THR B N   1 
ATOM   4304 C  CA  . THR B 1 85  ? -54.803 -32.744 -18.874 1.00 119.37 ?  85  THR B CA  1 
ATOM   4305 C  C   . THR B 1 85  ? -56.241 -32.381 -18.466 1.00 117.27 ?  85  THR B C   1 
ATOM   4306 O  O   . THR B 1 85  ? -56.420 -31.276 -17.917 1.00 114.78 ?  85  THR B O   1 
ATOM   4307 C  CB  . THR B 1 85  ? -54.418 -32.101 -20.214 1.00 120.13 ?  85  THR B CB  1 
ATOM   4308 O  OG1 . THR B 1 85  ? -54.263 -30.699 -19.989 1.00 112.92 ?  85  THR B OG1 1 
ATOM   4309 C  CG2 . THR B 1 85  ? -55.427 -32.338 -21.317 1.00 120.03 ?  85  THR B CG2 1 
ATOM   4310 N  N   . ARG B 1 86  ? -57.218 -33.254 -18.757 1.00 113.82 ?  86  ARG B N   1 
ATOM   4311 C  CA  . ARG B 1 86  ? -58.632 -33.137 -18.293 1.00 107.03 ?  86  ARG B CA  1 
ATOM   4312 C  C   . ARG B 1 86  ? -58.654 -32.927 -16.777 1.00 97.98  ?  86  ARG B C   1 
ATOM   4313 O  O   . ARG B 1 86  ? -58.136 -33.760 -16.036 1.00 91.00  ?  86  ARG B O   1 
ATOM   4314 C  CB  . ARG B 1 86  ? -59.430 -34.388 -18.683 1.00 106.34 ?  86  ARG B CB  1 
ATOM   4315 N  N   . PRO B 1 87  ? -59.243 -31.814 -16.270 1.00 91.40  ?  87  PRO B N   1 
ATOM   4316 C  CA  . PRO B 1 87  ? -59.261 -31.525 -14.832 1.00 88.76  ?  87  PRO B CA  1 
ATOM   4317 C  C   . PRO B 1 87  ? -59.922 -32.601 -13.954 1.00 87.76  ?  87  PRO B C   1 
ATOM   4318 O  O   . PRO B 1 87  ? -60.955 -33.109 -14.333 1.00 91.70  ?  87  PRO B O   1 
ATOM   4319 C  CB  . PRO B 1 87  ? -60.091 -30.234 -14.715 1.00 88.35  ?  87  PRO B CB  1 
ATOM   4320 C  CG  . PRO B 1 87  ? -60.021 -29.603 -16.090 1.00 90.04  ?  87  PRO B CG  1 
ATOM   4321 C  CD  . PRO B 1 87  ? -59.913 -30.764 -17.056 1.00 91.11  ?  87  PRO B CD  1 
ATOM   4322 N  N   . ALA B 1 88  ? -59.314 -32.903 -12.802 1.00 88.96  ?  88  ALA B N   1 
ATOM   4323 C  CA  . ALA B 1 88  ? -59.838 -33.837 -11.776 1.00 91.28  ?  88  ALA B CA  1 
ATOM   4324 C  C   . ALA B 1 88  ? -60.751 -33.075 -10.807 1.00 95.45  ?  88  ALA B C   1 
ATOM   4325 O  O   . ALA B 1 88  ? -60.285 -32.083 -10.214 1.00 97.45  ?  88  ALA B O   1 
ATOM   4326 C  CB  . ALA B 1 88  ? -58.699 -34.501 -11.043 1.00 89.48  ?  88  ALA B CB  1 
ATOM   4327 N  N   . MET B 1 89  ? -62.001 -33.526 -10.663 1.00 99.58  ?  89  MET B N   1 
ATOM   4328 C  CA  . MET B 1 89  ? -63.010 -32.950 -9.733  1.00 100.02 ?  89  MET B CA  1 
ATOM   4329 C  C   . MET B 1 89  ? -62.923 -33.690 -8.394  1.00 99.98  ?  89  MET B C   1 
ATOM   4330 O  O   . MET B 1 89  ? -62.914 -34.936 -8.410  1.00 96.60  ?  89  MET B O   1 
ATOM   4331 C  CB  . MET B 1 89  ? -64.427 -33.081 -10.302 1.00 101.22 ?  89  MET B CB  1 
ATOM   4332 C  CG  . MET B 1 89  ? -64.585 -32.513 -11.703 1.00 102.62 ?  89  MET B CG  1 
ATOM   4333 S  SD  . MET B 1 89  ? -64.350 -30.719 -11.772 1.00 109.59 ?  89  MET B SD  1 
ATOM   4334 C  CE  . MET B 1 89  ? -64.966 -30.364 -13.417 1.00 108.25 ?  89  MET B CE  1 
ATOM   4335 N  N   . LEU B 1 90  ? -62.840 -32.946 -7.287  1.00 101.89 ?  90  LEU B N   1 
ATOM   4336 C  CA  . LEU B 1 90  ? -62.711 -33.492 -5.907  1.00 103.62 ?  90  LEU B CA  1 
ATOM   4337 C  C   . LEU B 1 90  ? -63.611 -32.697 -4.966  1.00 106.04 ?  90  LEU B C   1 
ATOM   4338 O  O   . LEU B 1 90  ? -63.175 -31.708 -4.378  1.00 101.51 ?  90  LEU B O   1 
ATOM   4339 C  CB  . LEU B 1 90  ? -61.243 -33.414 -5.474  1.00 103.63 ?  90  LEU B CB  1 
ATOM   4340 C  CG  . LEU B 1 90  ? -60.283 -34.343 -6.215  1.00 104.18 ?  90  LEU B CG  1 
ATOM   4341 C  CD1 . LEU B 1 90  ? -58.840 -33.981 -5.903  1.00 105.17 ?  90  LEU B CD1 1 
ATOM   4342 C  CD2 . LEU B 1 90  ? -60.553 -35.801 -5.872  1.00 104.73 ?  90  LEU B CD2 1 
ATOM   4343 N  N   . PRO B 1 91  ? -64.891 -33.105 -4.797  1.00 112.02 ?  91  PRO B N   1 
ATOM   4344 C  CA  . PRO B 1 91  ? -65.846 -32.344 -3.993  1.00 111.16 ?  91  PRO B CA  1 
ATOM   4345 C  C   . PRO B 1 91  ? -65.771 -32.680 -2.496  1.00 107.42 ?  91  PRO B C   1 
ATOM   4346 O  O   . PRO B 1 91  ? -65.332 -33.771 -2.161  1.00 98.59  ?  91  PRO B O   1 
ATOM   4347 C  CB  . PRO B 1 91  ? -67.188 -32.781 -4.595  1.00 113.03 ?  91  PRO B CB  1 
ATOM   4348 C  CG  . PRO B 1 91  ? -66.958 -34.232 -4.982  1.00 113.12 ?  91  PRO B CG  1 
ATOM   4349 C  CD  . PRO B 1 91  ? -65.495 -34.320 -5.370  1.00 113.36 ?  91  PRO B CD  1 
ATOM   4350 N  N   . ALA B 1 92  ? -66.199 -31.733 -1.653  1.00 107.14 ?  92  ALA B N   1 
ATOM   4351 C  CA  . ALA B 1 92  ? -66.253 -31.843 -0.174  1.00 110.24 ?  92  ALA B CA  1 
ATOM   4352 C  C   . ALA B 1 92  ? -64.912 -32.371 0.355   1.00 111.05 ?  92  ALA B C   1 
ATOM   4353 O  O   . ALA B 1 92  ? -64.886 -33.488 0.912   1.00 111.47 ?  92  ALA B O   1 
ATOM   4354 C  CB  . ALA B 1 92  ? -67.408 -32.728 0.235   1.00 109.96 ?  92  ALA B CB  1 
ATOM   4355 N  N   . MET B 1 93  ? -63.843 -31.589 0.178   1.00 110.16 ?  93  MET B N   1 
ATOM   4356 C  CA  . MET B 1 93  ? -62.451 -31.961 0.554   1.00 109.15 ?  93  MET B CA  1 
ATOM   4357 C  C   . MET B 1 93  ? -62.017 -31.113 1.757   1.00 108.01 ?  93  MET B C   1 
ATOM   4358 O  O   . MET B 1 93  ? -62.128 -29.874 1.674   1.00 102.99 ?  93  MET B O   1 
ATOM   4359 C  CB  . MET B 1 93  ? -61.499 -31.741 -0.626  1.00 110.49 ?  93  MET B CB  1 
ATOM   4360 C  CG  . MET B 1 93  ? -60.194 -32.514 -0.522  1.00 113.71 ?  93  MET B CG  1 
ATOM   4361 S  SD  . MET B 1 93  ? -60.412 -34.315 -0.474  1.00 117.44 ?  93  MET B SD  1 
ATOM   4362 C  CE  . MET B 1 93  ? -60.849 -34.662 -2.175  1.00 114.12 ?  93  MET B CE  1 
ATOM   4363 N  N   . GLU B 1 94  ? -61.555 -31.765 2.831   1.00 111.08 ?  94  GLU B N   1 
ATOM   4364 C  CA  . GLU B 1 94  ? -61.253 -31.131 4.146   1.00 111.60 ?  94  GLU B CA  1 
ATOM   4365 C  C   . GLU B 1 94  ? -59.829 -30.561 4.137   1.00 111.83 ?  94  GLU B C   1 
ATOM   4366 O  O   . GLU B 1 94  ? -58.897 -31.294 3.744   1.00 111.77 ?  94  GLU B O   1 
ATOM   4367 C  CB  . GLU B 1 94  ? -61.428 -32.141 5.283   1.00 108.28 ?  94  GLU B CB  1 
ATOM   4368 N  N   . THR B 1 95  ? -59.679 -29.304 4.567   1.00 111.44 ?  95  THR B N   1 
ATOM   4369 C  CA  . THR B 1 95  ? -58.372 -28.581 4.660   1.00 112.59 ?  95  THR B CA  1 
ATOM   4370 C  C   . THR B 1 95  ? -57.717 -28.883 6.018   1.00 116.48 ?  95  THR B C   1 
ATOM   4371 O  O   . THR B 1 95  ? -57.869 -30.026 6.502   1.00 112.38 ?  95  THR B O   1 
ATOM   4372 C  CB  . THR B 1 95  ? -58.552 -27.079 4.399   1.00 108.16 ?  95  THR B CB  1 
ATOM   4373 O  OG1 . THR B 1 95  ? -59.401 -26.545 5.415   1.00 104.90 ?  95  THR B OG1 1 
ATOM   4374 C  CG2 . THR B 1 95  ? -59.138 -26.783 3.036   1.00 107.51 ?  95  THR B CG2 1 
ATOM   4375 N  N   . SER B 1 96  ? -57.001 -27.907 6.596   1.00 121.61 ?  96  SER B N   1 
ATOM   4376 C  CA  . SER B 1 96  ? -56.294 -28.014 7.903   1.00 120.88 ?  96  SER B CA  1 
ATOM   4377 C  C   . SER B 1 96  ? -57.243 -27.646 9.049   1.00 118.64 ?  96  SER B C   1 
ATOM   4378 O  O   . SER B 1 96  ? -57.307 -28.410 10.034  1.00 114.84 ?  96  SER B O   1 
ATOM   4379 C  CB  . SER B 1 96  ? -55.066 -27.138 7.927   1.00 120.64 ?  96  SER B CB  1 
ATOM   4380 O  OG  . SER B 1 96  ? -54.241 -27.383 6.798   1.00 120.82 ?  96  SER B OG  1 
ATOM   4381 N  N   . ASP B 1 97  ? -57.954 -26.523 8.908   1.00 118.82 ?  97  ASP B N   1 
ATOM   4382 C  CA  . ASP B 1 97  ? -58.861 -25.956 9.946   1.00 123.72 ?  97  ASP B CA  1 
ATOM   4383 C  C   . ASP B 1 97  ? -60.282 -26.521 9.772   1.00 125.08 ?  97  ASP B C   1 
ATOM   4384 O  O   . ASP B 1 97  ? -61.245 -25.826 10.159  1.00 124.11 ?  97  ASP B O   1 
ATOM   4385 C  CB  . ASP B 1 97  ? -58.813 -24.423 9.947   1.00 124.86 ?  97  ASP B CB  1 
ATOM   4386 C  CG  . ASP B 1 97  ? -58.941 -23.765 8.582   1.00 125.59 ?  97  ASP B CG  1 
ATOM   4387 O  OD1 . ASP B 1 97  ? -59.126 -24.495 7.588   1.00 131.38 ?  97  ASP B OD1 1 
ATOM   4388 O  OD2 . ASP B 1 97  ? -58.846 -22.522 8.524   1.00 117.99 ?  97  ASP B OD2 1 
ATOM   4389 N  N   . GLY B 1 98  ? -60.404 -27.732 9.212   1.00 127.27 ?  98  GLY B N   1 
ATOM   4390 C  CA  . GLY B 1 98  ? -61.628 -28.561 9.233   1.00 127.60 ?  98  GLY B CA  1 
ATOM   4391 C  C   . GLY B 1 98  ? -62.721 -28.071 8.294   1.00 128.87 ?  98  GLY B C   1 
ATOM   4392 O  O   . GLY B 1 98  ? -63.837 -28.627 8.374   1.00 129.57 ?  98  GLY B O   1 
ATOM   4393 N  N   . ARG B 1 99  ? -62.423 -27.103 7.417   1.00 127.61 ?  99  ARG B N   1 
ATOM   4394 C  CA  A ARG B 1 99  ? -63.420 -26.518 6.473   0.50 124.42 ?  99  ARG B CA  1 
ATOM   4395 C  CA  B ARG B 1 99  ? -63.411 -26.511 6.468   0.50 124.93 ?  99  ARG B CA  1 
ATOM   4396 C  C   . ARG B 1 99  ? -63.519 -27.405 5.228   1.00 122.73 ?  99  ARG B C   1 
ATOM   4397 O  O   . ARG B 1 99  ? -62.511 -28.057 4.888   1.00 124.99 ?  99  ARG B O   1 
ATOM   4398 C  CB  A ARG B 1 99  ? -63.043 -25.086 6.082   0.50 124.17 ?  99  ARG B CB  1 
ATOM   4399 C  CB  B ARG B 1 99  ? -62.990 -25.097 6.052   0.50 125.36 ?  99  ARG B CB  1 
ATOM   4400 C  CG  A ARG B 1 99  ? -63.551 -24.029 7.049   0.50 124.38 ?  99  ARG B CG  1 
ATOM   4401 C  CG  B ARG B 1 99  ? -62.757 -24.143 7.213   0.50 126.29 ?  99  ARG B CG  1 
ATOM   4402 C  CD  A ARG B 1 99  ? -63.394 -22.626 6.498   0.50 125.57 ?  99  ARG B CD  1 
ATOM   4403 C  CD  B ARG B 1 99  ? -61.869 -22.977 6.822   0.50 128.20 ?  99  ARG B CD  1 
ATOM   4404 N  NE  A ARG B 1 99  ? -62.030 -22.139 6.638   0.50 127.90 ?  99  ARG B NE  1 
ATOM   4405 N  NE  B ARG B 1 99  ? -62.592 -21.929 6.118   0.50 130.09 ?  99  ARG B NE  1 
ATOM   4406 C  CZ  A ARG B 1 99  ? -61.676 -20.862 6.550   0.50 128.91 ?  99  ARG B CZ  1 
ATOM   4407 C  CZ  B ARG B 1 99  ? -62.155 -20.683 5.977   0.50 131.63 ?  99  ARG B CZ  1 
ATOM   4408 N  NH1 A ARG B 1 99  ? -62.591 -19.935 6.322   0.50 128.95 ?  99  ARG B NH1 1 
ATOM   4409 N  NH1 B ARG B 1 99  ? -62.882 -19.794 5.321   0.50 131.41 ?  99  ARG B NH1 1 
ATOM   4410 N  NH2 A ARG B 1 99  ? -60.411 -20.515 6.696   0.50 128.42 ?  99  ARG B NH2 1 
ATOM   4411 N  NH2 B ARG B 1 99  ? -60.995 -20.328 6.500   0.50 131.76 ?  99  ARG B NH2 1 
ATOM   4412 N  N   . SER B 1 100 ? -64.693 -27.410 4.591   1.00 116.72 ?  100 SER B N   1 
ATOM   4413 C  CA  . SER B 1 100 ? -64.980 -28.174 3.345   1.00 110.01 ?  100 SER B CA  1 
ATOM   4414 C  C   . SER B 1 100 ? -64.843 -27.245 2.134   1.00 105.03 ?  100 SER B C   1 
ATOM   4415 O  O   . SER B 1 100 ? -65.402 -26.129 2.174   1.00 103.71 ?  100 SER B O   1 
ATOM   4416 C  CB  . SER B 1 100 ? -66.337 -28.826 3.386   1.00 108.31 ?  100 SER B CB  1 
ATOM   4417 O  OG  . SER B 1 100 ? -66.304 -30.015 4.160   1.00 109.91 ?  100 SER B OG  1 
ATOM   4418 N  N   . PHE B 1 101 ? -64.108 -27.696 1.114   1.00 98.12  ?  101 PHE B N   1 
ATOM   4419 C  CA  . PHE B 1 101 ? -63.903 -26.992 -0.179  1.00 93.66  ?  101 PHE B CA  1 
ATOM   4420 C  C   . PHE B 1 101 ? -64.018 -28.003 -1.325  1.00 92.12  ?  101 PHE B C   1 
ATOM   4421 O  O   . PHE B 1 101 ? -63.462 -29.117 -1.209  1.00 90.71  ?  101 PHE B O   1 
ATOM   4422 C  CB  . PHE B 1 101 ? -62.546 -26.283 -0.208  1.00 93.08  ?  101 PHE B CB  1 
ATOM   4423 C  CG  . PHE B 1 101 ? -62.497 -24.976 0.542   1.00 92.55  ?  101 PHE B CG  1 
ATOM   4424 C  CD1 . PHE B 1 101 ? -62.183 -24.945 1.891   1.00 93.31  ?  101 PHE B CD1 1 
ATOM   4425 C  CD2 . PHE B 1 101 ? -62.758 -23.775 -0.103  1.00 93.09  ?  101 PHE B CD2 1 
ATOM   4426 C  CE1 . PHE B 1 101 ? -62.138 -23.743 2.580   1.00 96.88  ?  101 PHE B CE1 1 
ATOM   4427 C  CE2 . PHE B 1 101 ? -62.711 -22.573 0.587   1.00 94.74  ?  101 PHE B CE2 1 
ATOM   4428 C  CZ  . PHE B 1 101 ? -62.401 -22.560 1.928   1.00 97.16  ?  101 PHE B CZ  1 
ATOM   4429 N  N   . ASP B 1 102 ? -64.739 -27.628 -2.385  1.00 89.65  ?  102 ASP B N   1 
ATOM   4430 C  CA  . ASP B 1 102 ? -64.796 -28.383 -3.664  1.00 87.02  ?  102 ASP B CA  1 
ATOM   4431 C  C   . ASP B 1 102 ? -63.568 -27.983 -4.485  1.00 84.05  ?  102 ASP B C   1 
ATOM   4432 O  O   . ASP B 1 102 ? -63.427 -26.779 -4.780  1.00 83.11  ?  102 ASP B O   1 
ATOM   4433 C  CB  . ASP B 1 102 ? -66.107 -28.123 -4.409  1.00 86.67  ?  102 ASP B CB  1 
ATOM   4434 C  CG  . ASP B 1 102 ? -67.337 -28.638 -3.683  1.00 84.79  ?  102 ASP B CG  1 
ATOM   4435 O  OD1 . ASP B 1 102 ? -67.212 -29.642 -2.947  1.00 81.00  ?  102 ASP B OD1 1 
ATOM   4436 O  OD2 . ASP B 1 102 ? -68.413 -28.029 -3.860  1.00 82.97  ?  102 ASP B OD2 1 
ATOM   4437 N  N   . ILE B 1 103 ? -62.709 -28.950 -4.817  1.00 81.06  ?  103 ILE B N   1 
ATOM   4438 C  CA  . ILE B 1 103 ? -61.354 -28.688 -5.385  1.00 80.90  ?  103 ILE B CA  1 
ATOM   4439 C  C   . ILE B 1 103 ? -61.268 -29.265 -6.802  1.00 78.06  ?  103 ILE B C   1 
ATOM   4440 O  O   . ILE B 1 103 ? -61.434 -30.490 -6.967  1.00 77.09  ?  103 ILE B O   1 
ATOM   4441 C  CB  . ILE B 1 103 ? -60.251 -29.229 -4.451  1.00 82.71  ?  103 ILE B CB  1 
ATOM   4442 C  CG1 . ILE B 1 103 ? -60.245 -28.472 -3.119  1.00 85.64  ?  103 ILE B CG1 1 
ATOM   4443 C  CG2 . ILE B 1 103 ? -58.889 -29.181 -5.132  1.00 82.48  ?  103 ILE B CG2 1 
ATOM   4444 C  CD1 . ILE B 1 103 ? -59.339 -29.063 -2.063  1.00 87.19  ?  103 ILE B CD1 1 
ATOM   4445 N  N   . SER B 1 104 ? -61.026 -28.385 -7.776  1.00 76.28  ?  104 SER B N   1 
ATOM   4446 C  CA  A SER B 1 104 ? -60.725 -28.747 -9.187  0.70 75.03  ?  104 SER B CA  1 
ATOM   4447 C  CA  B SER B 1 104 ? -60.725 -28.745 -9.187  0.30 74.20  ?  104 SER B CA  1 
ATOM   4448 C  C   . SER B 1 104 ? -59.210 -28.650 -9.410  1.00 73.55  ?  104 SER B C   1 
ATOM   4449 O  O   . SER B 1 104 ? -58.663 -27.544 -9.245  1.00 71.83  ?  104 SER B O   1 
ATOM   4450 C  CB  A SER B 1 104 ? -61.485 -27.875 -10.153 0.70 75.56  ?  104 SER B CB  1 
ATOM   4451 C  CB  B SER B 1 104 ? -61.503 -27.871 -10.138 0.30 73.63  ?  104 SER B CB  1 
ATOM   4452 O  OG  A SER B 1 104 ? -60.967 -28.007 -11.469 0.70 76.43  ?  104 SER B OG  1 
ATOM   4453 O  OG  B SER B 1 104 ? -62.133 -26.807 -9.439  0.30 72.09  ?  104 SER B OG  1 
ATOM   4454 N  N   . LEU B 1 105 ? -58.585 -29.777 -9.761  1.00 72.58  ?  105 LEU B N   1 
ATOM   4455 C  CA  . LEU B 1 105 ? -57.111 -29.955 -9.855  1.00 71.79  ?  105 LEU B CA  1 
ATOM   4456 C  C   . LEU B 1 105 ? -56.729 -30.371 -11.279 1.00 70.69  ?  105 LEU B C   1 
ATOM   4457 O  O   . LEU B 1 105 ? -57.411 -31.249 -11.834 1.00 72.76  ?  105 LEU B O   1 
ATOM   4458 C  CB  . LEU B 1 105 ? -56.718 -31.033 -8.841  1.00 72.79  ?  105 LEU B CB  1 
ATOM   4459 C  CG  . LEU B 1 105 ? -55.264 -31.491 -8.868  1.00 74.80  ?  105 LEU B CG  1 
ATOM   4460 C  CD1 . LEU B 1 105 ? -54.334 -30.362 -8.453  1.00 79.72  ?  105 LEU B CD1 1 
ATOM   4461 C  CD2 . LEU B 1 105 ? -55.075 -32.696 -7.964  1.00 74.64  ?  105 LEU B CD2 1 
ATOM   4462 N  N   . HIS B 1 106 ? -55.669 -29.785 -11.842 1.00 67.76  ?  106 HIS B N   1 
ATOM   4463 C  CA  . HIS B 1 106 ? -55.154 -30.151 -13.190 1.00 67.01  ?  106 HIS B CA  1 
ATOM   4464 C  C   . HIS B 1 106 ? -53.693 -29.723 -13.366 1.00 69.52  ?  106 HIS B C   1 
ATOM   4465 O  O   . HIS B 1 106 ? -53.283 -28.711 -12.767 1.00 73.81  ?  106 HIS B O   1 
ATOM   4466 C  CB  . HIS B 1 106 ? -56.065 -29.581 -14.286 1.00 64.70  ?  106 HIS B CB  1 
ATOM   4467 C  CG  . HIS B 1 106 ? -55.771 -28.174 -14.689 1.00 61.48  ?  106 HIS B CG  1 
ATOM   4468 N  ND1 . HIS B 1 106 ? -56.399 -27.093 -14.105 1.00 59.14  ?  106 HIS B ND1 1 
ATOM   4469 C  CD2 . HIS B 1 106 ? -54.954 -27.671 -15.641 1.00 58.98  ?  106 HIS B CD2 1 
ATOM   4470 C  CE1 . HIS B 1 106 ? -55.974 -25.982 -14.674 1.00 58.73  ?  106 HIS B CE1 1 
ATOM   4471 N  NE2 . HIS B 1 106 ? -55.086 -26.311 -15.619 1.00 57.46  ?  106 HIS B NE2 1 
ATOM   4472 N  N   . ARG B 1 107 ? -52.957 -30.487 -14.175 1.00 71.80  ?  107 ARG B N   1 
ATOM   4473 C  CA  . ARG B 1 107 ? -51.545 -30.217 -14.556 1.00 72.47  ?  107 ARG B CA  1 
ATOM   4474 C  C   . ARG B 1 107 ? -51.517 -29.829 -16.037 1.00 68.37  ?  107 ARG B C   1 
ATOM   4475 O  O   . ARG B 1 107 ? -52.088 -30.572 -16.850 1.00 68.05  ?  107 ARG B O   1 
ATOM   4476 C  CB  . ARG B 1 107 ? -50.685 -31.456 -14.283 1.00 79.81  ?  107 ARG B CB  1 
ATOM   4477 C  CG  . ARG B 1 107 ? -49.203 -31.169 -14.077 1.00 87.33  ?  107 ARG B CG  1 
ATOM   4478 C  CD  . ARG B 1 107 ? -48.356 -32.422 -14.220 1.00 91.50  ?  107 ARG B CD  1 
ATOM   4479 N  NE  . ARG B 1 107 ? -48.592 -33.378 -13.144 1.00 94.71  ?  107 ARG B NE  1 
ATOM   4480 C  CZ  . ARG B 1 107 ? -48.161 -34.638 -13.130 1.00 98.92  ?  107 ARG B CZ  1 
ATOM   4481 N  NH1 . ARG B 1 107 ? -47.464 -35.123 -14.145 1.00 102.44 ?  107 ARG B NH1 1 
ATOM   4482 N  NH2 . ARG B 1 107 ? -48.434 -35.415 -12.096 1.00 101.62 ?  107 ARG B NH2 1 
ATOM   4483 N  N   . TYR B 1 108 ? -50.893 -28.698 -16.366 1.00 69.35  ?  108 TYR B N   1 
ATOM   4484 C  CA  . TYR B 1 108 ? -50.779 -28.179 -17.756 1.00 70.12  ?  108 TYR B CA  1 
ATOM   4485 C  C   . TYR B 1 108 ? -49.648 -27.146 -17.826 1.00 71.81  ?  108 TYR B C   1 
ATOM   4486 O  O   . TYR B 1 108 ? -49.619 -26.227 -16.978 1.00 71.02  ?  108 TYR B O   1 
ATOM   4487 C  CB  . TYR B 1 108 ? -52.124 -27.607 -18.215 1.00 68.20  ?  108 TYR B CB  1 
ATOM   4488 C  CG  . TYR B 1 108 ? -52.134 -27.065 -19.622 1.00 66.28  ?  108 TYR B CG  1 
ATOM   4489 C  CD1 . TYR B 1 108 ? -51.918 -27.894 -20.709 1.00 67.36  ?  108 TYR B CD1 1 
ATOM   4490 C  CD2 . TYR B 1 108 ? -52.360 -25.721 -19.868 1.00 68.24  ?  108 TYR B CD2 1 
ATOM   4491 C  CE1 . TYR B 1 108 ? -51.922 -27.404 -22.005 1.00 69.38  ?  108 TYR B CE1 1 
ATOM   4492 C  CE2 . TYR B 1 108 ? -52.371 -25.215 -21.157 1.00 68.84  ?  108 TYR B CE2 1 
ATOM   4493 C  CZ  . TYR B 1 108 ? -52.150 -26.058 -22.231 1.00 70.19  ?  108 TYR B CZ  1 
ATOM   4494 O  OH  . TYR B 1 108 ? -52.157 -25.560 -23.501 1.00 74.76  ?  108 TYR B OH  1 
ATOM   4495 N  N   . LYS B 1 109 ? -48.757 -27.303 -18.813 1.00 73.52  ?  109 LYS B N   1 
ATOM   4496 C  CA  . LYS B 1 109 ? -47.563 -26.443 -19.039 1.00 75.63  ?  109 LYS B CA  1 
ATOM   4497 C  C   . LYS B 1 109 ? -46.653 -26.519 -17.807 1.00 74.14  ?  109 LYS B C   1 
ATOM   4498 O  O   . LYS B 1 109 ? -46.213 -25.456 -17.332 1.00 71.34  ?  109 LYS B O   1 
ATOM   4499 C  CB  . LYS B 1 109 ? -47.971 -24.993 -19.324 1.00 79.85  ?  109 LYS B CB  1 
ATOM   4500 C  CG  . LYS B 1 109 ? -48.906 -24.788 -20.509 1.00 82.99  ?  109 LYS B CG  1 
ATOM   4501 C  CD  . LYS B 1 109 ? -48.203 -24.553 -21.829 1.00 85.70  ?  109 LYS B CD  1 
ATOM   4502 C  CE  . LYS B 1 109 ? -49.006 -23.667 -22.760 1.00 89.27  ?  109 LYS B CE  1 
ATOM   4503 N  NZ  . LYS B 1 109 ? -48.418 -23.618 -24.119 1.00 93.40  ?  109 LYS B NZ  1 
ATOM   4504 N  N   . SER B 1 110 ? -46.416 -27.733 -17.296 1.00 75.23  ?  110 SER B N   1 
ATOM   4505 C  CA  . SER B 1 110 ? -45.502 -28.020 -16.155 1.00 78.73  ?  110 SER B CA  1 
ATOM   4506 C  C   . SER B 1 110 ? -45.969 -27.290 -14.889 1.00 76.99  ?  110 SER B C   1 
ATOM   4507 O  O   . SER B 1 110 ? -45.181 -27.228 -13.926 1.00 80.09  ?  110 SER B O   1 
ATOM   4508 C  CB  . SER B 1 110 ? -44.073 -27.659 -16.492 1.00 80.40  ?  110 SER B CB  1 
ATOM   4509 O  OG  . SER B 1 110 ? -43.659 -28.289 -17.697 1.00 82.96  ?  110 SER B OG  1 
ATOM   4510 N  N   . THR B 1 111 ? -47.198 -26.761 -14.898 1.00 74.57  ?  111 THR B N   1 
ATOM   4511 C  CA  . THR B 1 111 ? -47.836 -26.063 -13.746 1.00 71.85  ?  111 THR B CA  1 
ATOM   4512 C  C   . THR B 1 111 ? -49.022 -26.888 -13.240 1.00 70.96  ?  111 THR B C   1 
ATOM   4513 O  O   . THR B 1 111 ? -49.896 -27.222 -14.060 1.00 71.32  ?  111 THR B O   1 
ATOM   4514 C  CB  . THR B 1 111 ? -48.321 -24.660 -14.134 1.00 71.66  ?  111 THR B CB  1 
ATOM   4515 O  OG1 . THR B 1 111 ? -47.300 -24.002 -14.882 1.00 70.80  ?  111 THR B OG1 1 
ATOM   4516 C  CG2 . THR B 1 111 ? -48.692 -23.815 -12.934 1.00 71.06  ?  111 THR B CG2 1 
ATOM   4517 N  N   . THR B 1 112 ? -49.035 -27.208 -11.945 1.00 70.63  ?  112 THR B N   1 
ATOM   4518 C  CA  . THR B 1 112 ? -50.212 -27.784 -11.237 1.00 70.39  ?  112 THR B CA  1 
ATOM   4519 C  C   . THR B 1 112 ? -51.090 -26.633 -10.737 1.00 71.62  ?  112 THR B C   1 
ATOM   4520 O  O   . THR B 1 112 ? -50.547 -25.737 -10.069 1.00 72.35  ?  112 THR B O   1 
ATOM   4521 C  CB  . THR B 1 112 ? -49.779 -28.713 -10.098 1.00 69.36  ?  112 THR B CB  1 
ATOM   4522 O  OG1 . THR B 1 112 ? -49.249 -29.901 -10.686 1.00 69.23  ?  112 THR B OG1 1 
ATOM   4523 C  CG2 . THR B 1 112 ? -50.911 -29.075 -9.161  1.00 70.75  ?  112 THR B CG2 1 
ATOM   4524 N  N   . ILE B 1 113 ? -52.388 -26.663 -11.053 1.00 72.03  ?  113 ILE B N   1 
ATOM   4525 C  CA  . ILE B 1 113 ? -53.373 -25.618 -10.643 1.00 72.47  ?  113 ILE B CA  1 
ATOM   4526 C  C   . ILE B 1 113 ? -54.428 -26.268 -9.742  1.00 72.65  ?  113 ILE B C   1 
ATOM   4527 O  O   . ILE B 1 113 ? -55.049 -27.251 -10.178 1.00 77.27  ?  113 ILE B O   1 
ATOM   4528 C  CB  . ILE B 1 113 ? -53.986 -24.922 -11.875 1.00 71.69  ?  113 ILE B CB  1 
ATOM   4529 C  CG1 . ILE B 1 113 ? -52.895 -24.265 -12.728 1.00 73.11  ?  113 ILE B CG1 1 
ATOM   4530 C  CG2 . ILE B 1 113 ? -55.064 -23.930 -11.454 1.00 72.00  ?  113 ILE B CG2 1 
ATOM   4531 C  CD1 . ILE B 1 113 ? -53.399 -23.467 -13.911 1.00 75.44  ?  113 ILE B CD1 1 
ATOM   4532 N  N   . ILE B 1 114 ? -54.583 -25.752 -8.520  1.00 73.12  ?  114 ILE B N   1 
ATOM   4533 C  CA  . ILE B 1 114 ? -55.616 -26.196 -7.538  1.00 73.59  ?  114 ILE B CA  1 
ATOM   4534 C  C   . ILE B 1 114 ? -56.632 -25.062 -7.392  1.00 74.76  ?  114 ILE B C   1 
ATOM   4535 O  O   . ILE B 1 114 ? -56.244 -23.971 -6.924  1.00 77.83  ?  114 ILE B O   1 
ATOM   4536 C  CB  . ILE B 1 114 ? -55.006 -26.594 -6.178  1.00 74.16  ?  114 ILE B CB  1 
ATOM   4537 C  CG1 . ILE B 1 114 ? -53.741 -27.443 -6.329  1.00 76.80  ?  114 ILE B CG1 1 
ATOM   4538 C  CG2 . ILE B 1 114 ? -56.042 -27.295 -5.313  1.00 76.04  ?  114 ILE B CG2 1 
ATOM   4539 C  CD1 . ILE B 1 114 ? -52.460 -26.676 -6.115  1.00 78.90  ?  114 ILE B CD1 1 
ATOM   4540 N  N   . GLU B 1 115 ? -57.879 -25.320 -7.793  1.00 73.58  ?  115 GLU B N   1 
ATOM   4541 C  CA  . GLU B 1 115 ? -59.004 -24.358 -7.688  1.00 70.57  ?  115 GLU B CA  1 
ATOM   4542 C  C   . GLU B 1 115 ? -59.859 -24.744 -6.478  1.00 70.79  ?  115 GLU B C   1 
ATOM   4543 O  O   . GLU B 1 115 ? -60.072 -25.952 -6.268  1.00 69.71  ?  115 GLU B O   1 
ATOM   4544 C  CB  . GLU B 1 115 ? -59.785 -24.341 -8.998  1.00 70.65  ?  115 GLU B CB  1 
ATOM   4545 C  CG  . GLU B 1 115 ? -58.980 -23.774 -10.150 1.00 69.91  ?  115 GLU B CG  1 
ATOM   4546 C  CD  . GLU B 1 115 ? -59.721 -23.751 -11.472 1.00 67.86  ?  115 GLU B CD  1 
ATOM   4547 O  OE1 . GLU B 1 115 ? -59.968 -24.843 -12.021 1.00 68.35  ?  115 GLU B OE1 1 
ATOM   4548 O  OE2 . GLU B 1 115 ? -60.059 -22.645 -11.938 1.00 63.51  ?  115 GLU B OE2 1 
ATOM   4549 N  N   . PHE B 1 116 ? -60.294 -23.740 -5.710  1.00 71.70  ?  116 PHE B N   1 
ATOM   4550 C  CA  . PHE B 1 116 ? -61.032 -23.880 -4.428  1.00 72.40  ?  116 PHE B CA  1 
ATOM   4551 C  C   . PHE B 1 116 ? -62.361 -23.124 -4.517  1.00 73.14  ?  116 PHE B C   1 
ATOM   4552 O  O   . PHE B 1 116 ? -62.340 -21.911 -4.811  1.00 69.55  ?  116 PHE B O   1 
ATOM   4553 C  CB  . PHE B 1 116 ? -60.198 -23.337 -3.265  1.00 72.68  ?  116 PHE B CB  1 
ATOM   4554 C  CG  . PHE B 1 116 ? -58.914 -24.082 -3.005  1.00 72.10  ?  116 PHE B CG  1 
ATOM   4555 C  CD1 . PHE B 1 116 ? -58.891 -25.182 -2.160  1.00 72.02  ?  116 PHE B CD1 1 
ATOM   4556 C  CD2 . PHE B 1 116 ? -57.727 -23.681 -3.599  1.00 71.75  ?  116 PHE B CD2 1 
ATOM   4557 C  CE1 . PHE B 1 116 ? -57.709 -25.867 -1.920  1.00 72.06  ?  116 PHE B CE1 1 
ATOM   4558 C  CE2 . PHE B 1 116 ? -56.547 -24.368 -3.361  1.00 70.81  ?  116 PHE B CE2 1 
ATOM   4559 C  CZ  . PHE B 1 116 ? -56.540 -25.459 -2.521  1.00 70.91  ?  116 PHE B CZ  1 
ATOM   4560 N  N   . GLU B 1 117 ? -63.471 -23.831 -4.279  1.00 76.75  ?  117 GLU B N   1 
ATOM   4561 C  CA  . GLU B 1 117 ? -64.833 -23.252 -4.122  1.00 81.91  ?  117 GLU B CA  1 
ATOM   4562 C  C   . GLU B 1 117 ? -65.376 -23.652 -2.757  1.00 83.88  ?  117 GLU B C   1 
ATOM   4563 O  O   . GLU B 1 117 ? -65.194 -24.795 -2.338  1.00 79.74  ?  117 GLU B O   1 
ATOM   4564 C  CB  . GLU B 1 117 ? -65.800 -23.776 -5.183  1.00 86.32  ?  117 GLU B CB  1 
ATOM   4565 C  CG  . GLU B 1 117 ? -65.437 -23.402 -6.603  1.00 90.08  ?  117 GLU B CG  1 
ATOM   4566 C  CD  . GLU B 1 117 ? -66.089 -24.305 -7.634  1.00 90.86  ?  117 GLU B CD  1 
ATOM   4567 O  OE1 . GLU B 1 117 ? -65.857 -25.532 -7.578  1.00 88.59  ?  117 GLU B OE1 1 
ATOM   4568 O  OE2 . GLU B 1 117 ? -66.839 -23.784 -8.478  1.00 93.89  ?  117 GLU B OE2 1 
ATOM   4569 N  N   . PRO B 1 118 ? -66.061 -22.740 -2.026  1.00 87.77  ?  118 PRO B N   1 
ATOM   4570 C  CA  . PRO B 1 118 ? -66.720 -23.110 -0.776  1.00 89.81  ?  118 PRO B CA  1 
ATOM   4571 C  C   . PRO B 1 118 ? -67.720 -24.241 -1.050  1.00 91.26  ?  118 PRO B C   1 
ATOM   4572 O  O   . PRO B 1 118 ? -68.626 -24.032 -1.833  1.00 90.56  ?  118 PRO B O   1 
ATOM   4573 C  CB  . PRO B 1 118 ? -67.420 -21.822 -0.313  1.00 91.35  ?  118 PRO B CB  1 
ATOM   4574 C  CG  . PRO B 1 118 ? -66.690 -20.710 -1.040  1.00 90.77  ?  118 PRO B CG  1 
ATOM   4575 C  CD  . PRO B 1 118 ? -66.242 -21.318 -2.354  1.00 90.16  ?  118 PRO B CD  1 
ATOM   4576 N  N   . SER B 1 119 ? -67.499 -25.406 -0.435  1.00 96.16  ?  119 SER B N   1 
ATOM   4577 C  CA  . SER B 1 119 ? -68.302 -26.643 -0.641  1.00 103.02 ?  119 SER B CA  1 
ATOM   4578 C  C   . SER B 1 119 ? -69.734 -26.442 -0.122  1.00 113.07 ?  119 SER B C   1 
ATOM   4579 O  O   . SER B 1 119 ? -69.922 -26.438 1.109   1.00 117.82 ?  119 SER B O   1 
ATOM   4580 C  CB  . SER B 1 119 ? -67.632 -27.826 0.013   1.00 101.03 ?  119 SER B CB  1 
ATOM   4581 O  OG  . SER B 1 119 ? -68.355 -29.025 -0.222  1.00 101.99 ?  119 SER B OG  1 
ATOM   4582 N  N   . ASP B 1 120 ? -70.696 -26.267 -1.036  1.00 125.19 ?  120 ASP B N   1 
ATOM   4583 C  CA  . ASP B 1 120 ? -72.158 -26.243 -0.747  1.00 131.27 ?  120 ASP B CA  1 
ATOM   4584 C  C   . ASP B 1 120 ? -72.775 -27.559 -1.243  1.00 137.09 ?  120 ASP B C   1 
ATOM   4585 O  O   . ASP B 1 120 ? -73.987 -27.570 -1.544  1.00 142.29 ?  120 ASP B O   1 
ATOM   4586 C  CB  . ASP B 1 120 ? -72.826 -25.019 -1.382  1.00 125.37 ?  120 ASP B CB  1 
ATOM   4587 N  N   . SER B 1 121 ? -71.966 -28.623 -1.305  1.00 136.41 ?  121 SER B N   1 
ATOM   4588 C  CA  . SER B 1 121 ? -72.308 -29.933 -1.925  1.00 135.54 ?  121 SER B CA  1 
ATOM   4589 C  C   . SER B 1 121 ? -73.260 -30.725 -1.019  1.00 134.98 ?  121 SER B C   1 
ATOM   4590 O  O   . SER B 1 121 ? -72.827 -31.146 0.073   1.00 130.34 ?  121 SER B O   1 
ATOM   4591 C  CB  . SER B 1 121 ? -71.061 -30.729 -2.225  1.00 135.75 ?  121 SER B CB  1 
ATOM   4592 O  OG  . SER B 1 121 ? -70.110 -29.937 -2.919  1.00 134.52 ?  121 SER B OG  1 
ATOM   4593 N  N   . ASP B 1 122 ? -74.506 -30.910 -1.469  1.00 137.64 ?  122 ASP B N   1 
ATOM   4594 C  CA  . ASP B 1 122 ? -75.509 -31.829 -0.862  1.00 138.39 ?  122 ASP B CA  1 
ATOM   4595 C  C   . ASP B 1 122 ? -76.338 -32.469 -1.985  1.00 136.54 ?  122 ASP B C   1 
ATOM   4596 O  O   . ASP B 1 122 ? -77.533 -32.752 -1.752  1.00 134.16 ?  122 ASP B O   1 
ATOM   4597 C  CB  . ASP B 1 122 ? -76.386 -31.094 0.156   1.00 137.66 ?  122 ASP B CB  1 
ATOM   4598 N  N   . THR B 1 123 ? -75.712 -32.710 -3.145  1.00 132.67 ?  123 THR B N   1 
ATOM   4599 C  CA  . THR B 1 123 ? -76.368 -33.187 -4.398  1.00 128.30 ?  123 THR B CA  1 
ATOM   4600 C  C   . THR B 1 123 ? -75.688 -34.479 -4.865  1.00 128.60 ?  123 THR B C   1 
ATOM   4601 O  O   . THR B 1 123 ? -74.518 -34.699 -4.488  1.00 127.03 ?  123 THR B O   1 
ATOM   4602 C  CB  . THR B 1 123 ? -76.308 -32.114 -5.495  1.00 124.10 ?  123 THR B CB  1 
ATOM   4603 O  OG1 . THR B 1 123 ? -76.791 -30.890 -4.942  1.00 124.08 ?  123 THR B OG1 1 
ATOM   4604 C  CG2 . THR B 1 123 ? -77.113 -32.462 -6.729  1.00 122.91 ?  123 THR B CG2 1 
ATOM   4605 N  N   . GLN B 1 124 ? -76.403 -35.296 -5.646  1.00 129.17 ?  124 GLN B N   1 
ATOM   4606 C  CA  . GLN B 1 124 ? -75.861 -36.490 -6.353  1.00 129.05 ?  124 GLN B CA  1 
ATOM   4607 C  C   . GLN B 1 124 ? -75.652 -36.133 -7.825  1.00 126.76 ?  124 GLN B C   1 
ATOM   4608 O  O   . GLN B 1 124 ? -76.625 -35.903 -8.540  1.00 123.53 ?  124 GLN B O   1 
ATOM   4609 C  CB  . GLN B 1 124 ? -76.815 -37.677 -6.199  1.00 128.56 ?  124 GLN B CB  1 
ATOM   4610 N  N   . PRO B 1 125 ? -74.392 -36.064 -8.327  1.00 123.64 ?  125 PRO B N   1 
ATOM   4611 C  CA  . PRO B 1 125 ? -74.140 -35.747 -9.734  1.00 119.53 ?  125 PRO B CA  1 
ATOM   4612 C  C   . PRO B 1 125 ? -74.733 -36.791 -10.694 1.00 117.42 ?  125 PRO B C   1 
ATOM   4613 O  O   . PRO B 1 125 ? -75.416 -36.401 -11.623 1.00 116.43 ?  125 PRO B O   1 
ATOM   4614 C  CB  . PRO B 1 125 ? -72.606 -35.724 -9.864  1.00 119.04 ?  125 PRO B CB  1 
ATOM   4615 C  CG  . PRO B 1 125 ? -72.095 -35.604 -8.441  1.00 119.57 ?  125 PRO B CG  1 
ATOM   4616 C  CD  . PRO B 1 125 ? -73.143 -36.276 -7.577  1.00 122.11 ?  125 PRO B CD  1 
ATOM   4617 N  N   . LEU B 1 126 ? -74.463 -38.076 -10.441 1.00 115.55 ?  126 LEU B N   1 
ATOM   4618 C  CA  . LEU B 1 126 ? -74.928 -39.217 -11.281 1.00 115.91 ?  126 LEU B CA  1 
ATOM   4619 C  C   . LEU B 1 126 ? -76.455 -39.345 -11.195 1.00 112.50 ?  126 LEU B C   1 
ATOM   4620 O  O   . LEU B 1 126 ? -77.052 -39.844 -12.166 1.00 117.31 ?  126 LEU B O   1 
ATOM   4621 C  CB  . LEU B 1 126 ? -74.231 -40.510 -10.840 1.00 118.91 ?  126 LEU B CB  1 
ATOM   4622 C  CG  . LEU B 1 126 ? -72.975 -40.881 -11.630 1.00 121.59 ?  126 LEU B CG  1 
ATOM   4623 C  CD1 . LEU B 1 126 ? -71.948 -39.758 -11.594 1.00 121.08 ?  126 LEU B CD1 1 
ATOM   4624 C  CD2 . LEU B 1 126 ? -72.367 -42.177 -11.111 1.00 121.55 ?  126 LEU B CD2 1 
ATOM   4625 N  N   . GLY B 1 127 ? -77.058 -38.914 -10.082 1.00 107.60 ?  127 GLY B N   1 
ATOM   4626 C  CA  . GLY B 1 127 ? -78.521 -38.912 -9.880  1.00 103.34 ?  127 GLY B CA  1 
ATOM   4627 C  C   . GLY B 1 127 ? -79.213 -37.894 -10.774 1.00 98.26  ?  127 GLY B C   1 
ATOM   4628 O  O   . GLY B 1 127 ? -80.137 -38.288 -11.515 1.00 95.32  ?  127 GLY B O   1 
ATOM   4629 N  N   . THR B 1 128 ? -78.779 -36.631 -10.701 1.00 93.56  ?  128 THR B N   1 
ATOM   4630 C  CA  . THR B 1 128 ? -79.309 -35.491 -11.507 1.00 88.84  ?  128 THR B CA  1 
ATOM   4631 C  C   . THR B 1 128 ? -79.149 -35.791 -13.003 1.00 83.32  ?  128 THR B C   1 
ATOM   4632 O  O   . THR B 1 128 ? -80.111 -35.556 -13.760 1.00 78.40  ?  128 THR B O   1 
ATOM   4633 C  CB  . THR B 1 128 ? -78.591 -34.179 -11.157 1.00 89.14  ?  128 THR B CB  1 
ATOM   4634 O  OG1 . THR B 1 128 ? -78.594 -34.026 -9.737  1.00 89.64  ?  128 THR B OG1 1 
ATOM   4635 C  CG2 . THR B 1 128 ? -79.221 -32.963 -11.801 1.00 88.68  ?  128 THR B CG2 1 
ATOM   4636 N  N   . ALA B 1 129 ? -77.971 -36.284 -13.397 1.00 78.57  ?  129 ALA B N   1 
ATOM   4637 C  CA  . ALA B 1 129 ? -77.572 -36.548 -14.800 1.00 76.26  ?  129 ALA B CA  1 
ATOM   4638 C  C   . ALA B 1 129 ? -78.399 -37.706 -15.371 1.00 75.30  ?  129 ALA B C   1 
ATOM   4639 O  O   . ALA B 1 129 ? -78.892 -37.570 -16.506 1.00 75.16  ?  129 ALA B O   1 
ATOM   4640 C  CB  . ALA B 1 129 ? -76.093 -36.837 -14.874 1.00 75.29  ?  129 ALA B CB  1 
ATOM   4641 N  N   . ARG B 1 130 ? -78.551 -38.798 -14.614 1.00 75.44  ?  130 ARG B N   1 
ATOM   4642 C  CA  . ARG B 1 130 ? -79.321 -39.996 -15.056 1.00 76.36  ?  130 ARG B CA  1 
ATOM   4643 C  C   . ARG B 1 130 ? -80.761 -39.577 -15.384 1.00 71.85  ?  130 ARG B C   1 
ATOM   4644 O  O   . ARG B 1 130 ? -81.286 -40.049 -16.412 1.00 67.15  ?  130 ARG B O   1 
ATOM   4645 C  CB  . ARG B 1 130 ? -79.269 -41.100 -13.995 1.00 81.91  ?  130 ARG B CB  1 
ATOM   4646 C  CG  . ARG B 1 130 ? -80.177 -42.288 -14.284 1.00 90.43  ?  130 ARG B CG  1 
ATOM   4647 C  CD  . ARG B 1 130 ? -79.703 -43.589 -13.660 1.00 97.05  ?  130 ARG B CD  1 
ATOM   4648 N  NE  . ARG B 1 130 ? -79.191 -43.423 -12.304 1.00 106.40 ?  130 ARG B NE  1 
ATOM   4649 C  CZ  . ARG B 1 130 ? -79.936 -43.227 -11.216 1.00 110.47 ?  130 ARG B CZ  1 
ATOM   4650 N  NH1 . ARG B 1 130 ? -81.256 -43.158 -11.302 1.00 110.41 ?  130 ARG B NH1 1 
ATOM   4651 N  NH2 . ARG B 1 130 ? -79.350 -43.090 -10.038 1.00 110.00 ?  130 ARG B NH2 1 
ATOM   4652 N  N   . LYS B 1 131 ? -81.359 -38.710 -14.558 1.00 70.21  ?  131 LYS B N   1 
ATOM   4653 C  CA  . LYS B 1 131 ? -82.747 -38.193 -14.735 1.00 71.30  ?  131 LYS B CA  1 
ATOM   4654 C  C   . LYS B 1 131 ? -82.838 -37.403 -16.050 1.00 71.43  ?  131 LYS B C   1 
ATOM   4655 O  O   . LYS B 1 131 ? -83.686 -37.764 -16.892 1.00 72.60  ?  131 LYS B O   1 
ATOM   4656 C  CB  . LYS B 1 131 ? -83.164 -37.331 -13.538 1.00 70.85  ?  131 LYS B CB  1 
ATOM   4657 N  N   . MET B 1 132 ? -81.992 -36.378 -16.218 1.00 71.09  ?  132 MET B N   1 
ATOM   4658 C  CA  . MET B 1 132 ? -81.953 -35.495 -17.419 1.00 68.61  ?  132 MET B CA  1 
ATOM   4659 C  C   . MET B 1 132 ? -81.700 -36.333 -18.679 1.00 67.41  ?  132 MET B C   1 
ATOM   4660 O  O   . MET B 1 132 ? -82.334 -36.056 -19.710 1.00 69.31  ?  132 MET B O   1 
ATOM   4661 C  CB  . MET B 1 132 ? -80.844 -34.443 -17.313 1.00 70.42  ?  132 MET B CB  1 
ATOM   4662 C  CG  . MET B 1 132 ? -81.088 -33.375 -16.266 1.00 72.30  ?  132 MET B CG  1 
ATOM   4663 S  SD  . MET B 1 132 ? -79.658 -32.262 -16.108 1.00 74.75  ?  132 MET B SD  1 
ATOM   4664 C  CE  . MET B 1 132 ? -80.013 -31.071 -17.399 1.00 73.57  ?  132 MET B CE  1 
ATOM   4665 N  N   . VAL B 1 133 ? -80.789 -37.305 -18.604 1.00 67.46  ?  133 VAL B N   1 
ATOM   4666 C  CA  . VAL B 1 133 ? -80.361 -38.131 -19.773 1.00 67.39  ?  133 VAL B CA  1 
ATOM   4667 C  C   . VAL B 1 133 ? -81.521 -39.042 -20.195 1.00 66.61  ?  133 VAL B C   1 
ATOM   4668 O  O   . VAL B 1 133 ? -81.699 -39.233 -21.412 1.00 66.55  ?  133 VAL B O   1 
ATOM   4669 C  CB  . VAL B 1 133 ? -79.076 -38.923 -19.465 1.00 68.17  ?  133 VAL B CB  1 
ATOM   4670 C  CG1 . VAL B 1 133 ? -78.804 -40.007 -20.502 1.00 68.78  ?  133 VAL B CG1 1 
ATOM   4671 C  CG2 . VAL B 1 133 ? -77.875 -37.996 -19.339 1.00 67.27  ?  133 VAL B CG2 1 
ATOM   4672 N  N   . ASP B 1 134 ? -82.286 -39.568 -19.234 1.00 65.97  ?  134 ASP B N   1 
ATOM   4673 C  CA  . ASP B 1 134 ? -83.437 -40.476 -19.495 1.00 68.60  ?  134 ASP B CA  1 
ATOM   4674 C  C   . ASP B 1 134 ? -84.514 -39.738 -20.300 1.00 67.47  ?  134 ASP B C   1 
ATOM   4675 O  O   . ASP B 1 134 ? -85.215 -40.396 -21.089 1.00 72.71  ?  134 ASP B O   1 
ATOM   4676 C  CB  . ASP B 1 134 ? -84.016 -41.042 -18.196 1.00 71.69  ?  134 ASP B CB  1 
ATOM   4677 C  CG  . ASP B 1 134 ? -83.287 -42.271 -17.679 1.00 75.23  ?  134 ASP B CG  1 
ATOM   4678 O  OD1 . ASP B 1 134 ? -82.335 -42.724 -18.353 1.00 78.58  ?  134 ASP B OD1 1 
ATOM   4679 O  OD2 . ASP B 1 134 ? -83.677 -42.768 -16.605 1.00 81.21  ?  134 ASP B OD2 1 
ATOM   4680 N  N   . ARG B 1 135 ? -84.627 -38.422 -20.117 1.00 65.32  ?  135 ARG B N   1 
ATOM   4681 C  CA  . ARG B 1 135 ? -85.682 -37.589 -20.759 1.00 62.81  ?  135 ARG B CA  1 
ATOM   4682 C  C   . ARG B 1 135 ? -85.256 -37.152 -22.170 1.00 63.62  ?  135 ARG B C   1 
ATOM   4683 O  O   . ARG B 1 135 ? -86.101 -36.565 -22.868 1.00 67.16  ?  135 ARG B O   1 
ATOM   4684 C  CB  . ARG B 1 135 ? -86.019 -36.409 -19.846 1.00 61.78  ?  135 ARG B CB  1 
ATOM   4685 C  CG  . ARG B 1 135 ? -86.687 -36.845 -18.548 1.00 64.00  ?  135 ARG B CG  1 
ATOM   4686 C  CD  . ARG B 1 135 ? -87.073 -35.701 -17.634 1.00 65.59  ?  135 ARG B CD  1 
ATOM   4687 N  NE  . ARG B 1 135 ? -88.070 -34.828 -18.235 1.00 66.66  ?  135 ARG B NE  1 
ATOM   4688 C  CZ  . ARG B 1 135 ? -88.555 -33.729 -17.670 1.00 71.54  ?  135 ARG B CZ  1 
ATOM   4689 N  NH1 . ARG B 1 135 ? -88.142 -33.359 -16.469 1.00 74.40  ?  135 ARG B NH1 1 
ATOM   4690 N  NH2 . ARG B 1 135 ? -89.454 -32.999 -18.307 1.00 75.49  ?  135 ARG B NH2 1 
ATOM   4691 N  N   . ILE B 1 136 ? -84.016 -37.426 -22.595 1.00 62.96  ?  136 ILE B N   1 
ATOM   4692 C  CA  . ILE B 1 136 ? -83.540 -37.108 -23.979 1.00 63.95  ?  136 ILE B CA  1 
ATOM   4693 C  C   . ILE B 1 136 ? -83.186 -38.390 -24.746 1.00 64.89  ?  136 ILE B C   1 
ATOM   4694 O  O   . ILE B 1 136 ? -83.123 -38.308 -25.986 1.00 63.44  ?  136 ILE B O   1 
ATOM   4695 C  CB  . ILE B 1 136 ? -82.359 -36.113 -23.972 1.00 64.44  ?  136 ILE B CB  1 
ATOM   4696 C  CG1 . ILE B 1 136 ? -81.113 -36.680 -23.284 1.00 66.15  ?  136 ILE B CG1 1 
ATOM   4697 C  CG2 . ILE B 1 136 ? -82.777 -34.778 -23.372 1.00 61.78  ?  136 ILE B CG2 1 
ATOM   4698 C  CD1 . ILE B 1 136 ? -79.824 -36.017 -23.715 1.00 66.45  ?  136 ILE B CD1 1 
ATOM   4699 N  N   . ARG B 1 137 ? -82.959 -39.523 -24.068 1.00 69.96  ?  137 ARG B N   1 
ATOM   4700 C  CA  . ARG B 1 137 ? -82.407 -40.749 -24.717 1.00 74.36  ?  137 ARG B CA  1 
ATOM   4701 C  C   . ARG B 1 137 ? -83.392 -41.316 -25.749 1.00 74.28  ?  137 ARG B C   1 
ATOM   4702 O  O   . ARG B 1 137 ? -82.940 -42.072 -26.622 1.00 78.77  ?  137 ARG B O   1 
ATOM   4703 C  CB  . ARG B 1 137 ? -82.029 -41.812 -23.679 1.00 80.02  ?  137 ARG B CB  1 
ATOM   4704 C  CG  . ARG B 1 137 ? -83.199 -42.485 -22.974 1.00 86.72  ?  137 ARG B CG  1 
ATOM   4705 C  CD  . ARG B 1 137 ? -82.778 -43.658 -22.096 1.00 91.09  ?  137 ARG B CD  1 
ATOM   4706 N  NE  . ARG B 1 137 ? -82.439 -44.856 -22.864 1.00 95.78  ?  137 ARG B NE  1 
ATOM   4707 C  CZ  . ARG B 1 137 ? -81.220 -45.186 -23.299 1.00 98.61  ?  137 ARG B CZ  1 
ATOM   4708 N  NH1 . ARG B 1 137 ? -80.173 -44.415 -23.050 1.00 100.75 ?  137 ARG B NH1 1 
ATOM   4709 N  NH2 . ARG B 1 137 ? -81.052 -46.302 -23.988 1.00 96.50  ?  137 ARG B NH2 1 
ATOM   4710 N  N   . GLU B 1 138 ? -84.675 -40.957 -25.661 1.00 74.67  ?  138 GLU B N   1 
ATOM   4711 C  CA  . GLU B 1 138 ? -85.775 -41.570 -26.455 1.00 76.14  ?  138 GLU B CA  1 
ATOM   4712 C  C   . GLU B 1 138 ? -86.232 -40.621 -27.573 1.00 70.46  ?  138 GLU B C   1 
ATOM   4713 O  O   . GLU B 1 138 ? -87.096 -41.032 -28.370 1.00 71.80  ?  138 GLU B O   1 
ATOM   4714 C  CB  . GLU B 1 138 ? -86.937 -41.949 -25.534 1.00 84.26  ?  138 GLU B CB  1 
ATOM   4715 C  CG  . GLU B 1 138 ? -87.324 -40.847 -24.564 1.00 92.94  ?  138 GLU B CG  1 
ATOM   4716 C  CD  . GLU B 1 138 ? -88.690 -41.014 -23.927 1.00 100.01 ?  138 GLU B CD  1 
ATOM   4717 O  OE1 . GLU B 1 138 ? -89.537 -40.112 -24.111 1.00 106.08 ?  138 GLU B OE1 1 
ATOM   4718 O  OE2 . GLU B 1 138 ? -88.894 -42.030 -23.225 1.00 101.73 ?  138 GLU B OE2 1 
ATOM   4719 N  N   . ALA B 1 139 ? -85.680 -39.408 -27.644 1.00 64.08  ?  139 ALA B N   1 
ATOM   4720 C  CA  . ALA B 1 139 ? -85.926 -38.459 -28.755 1.00 63.75  ?  139 ALA B CA  1 
ATOM   4721 C  C   . ALA B 1 139 ? -85.604 -39.158 -30.083 1.00 61.99  ?  139 ALA B C   1 
ATOM   4722 O  O   . ALA B 1 139 ? -84.552 -39.812 -30.165 1.00 62.69  ?  139 ALA B O   1 
ATOM   4723 C  CB  . ALA B 1 139 ? -85.109 -37.203 -28.568 1.00 63.93  ?  139 ALA B CB  1 
ATOM   4724 N  N   . ASP B 1 140 ? -86.487 -39.028 -31.075 1.00 62.96  ?  140 ASP B N   1 
ATOM   4725 C  CA  . ASP B 1 140 ? -86.443 -39.797 -32.350 1.00 64.14  ?  140 ASP B CA  1 
ATOM   4726 C  C   . ASP B 1 140 ? -86.025 -38.884 -33.508 1.00 59.94  ?  140 ASP B C   1 
ATOM   4727 O  O   . ASP B 1 140 ? -85.956 -39.383 -34.643 1.00 60.45  ?  140 ASP B O   1 
ATOM   4728 C  CB  . ASP B 1 140 ? -87.790 -40.471 -32.638 1.00 69.94  ?  140 ASP B CB  1 
ATOM   4729 C  CG  . ASP B 1 140 ? -88.984 -39.530 -32.732 1.00 75.49  ?  140 ASP B CG  1 
ATOM   4730 O  OD1 . ASP B 1 140 ? -88.852 -38.345 -32.347 1.00 78.35  ?  140 ASP B OD1 1 
ATOM   4731 O  OD2 . ASP B 1 140 ? -90.047 -39.993 -33.186 1.00 82.95  ?  140 ASP B OD2 1 
ATOM   4732 N  N   . SER B 1 141 ? -85.746 -37.607 -33.231 1.00 58.36  ?  141 SER B N   1 
ATOM   4733 C  CA  . SER B 1 141 ? -85.336 -36.603 -34.255 1.00 56.17  ?  141 SER B CA  1 
ATOM   4734 C  C   . SER B 1 141 ? -84.449 -35.528 -33.621 1.00 54.24  ?  141 SER B C   1 
ATOM   4735 O  O   . SER B 1 141 ? -84.507 -35.353 -32.391 1.00 51.54  ?  141 SER B O   1 
ATOM   4736 C  CB  . SER B 1 141 ? -86.532 -35.982 -34.932 1.00 55.64  ?  141 SER B CB  1 
ATOM   4737 O  OG  . SER B 1 141 ? -87.320 -35.252 -34.003 1.00 54.51  ?  141 SER B OG  1 
ATOM   4738 N  N   . VAL B 1 142 ? -83.688 -34.815 -34.451 1.00 55.49  ?  142 VAL B N   1 
ATOM   4739 C  CA  . VAL B 1 142 ? -82.809 -33.687 -34.021 1.00 55.63  ?  142 VAL B CA  1 
ATOM   4740 C  C   . VAL B 1 142 ? -83.685 -32.595 -33.397 1.00 56.46  ?  142 VAL B C   1 
ATOM   4741 O  O   . VAL B 1 142 ? -83.333 -32.128 -32.301 1.00 59.64  ?  142 VAL B O   1 
ATOM   4742 C  CB  . VAL B 1 142 ? -81.968 -33.135 -35.188 1.00 56.83  ?  142 VAL B CB  1 
ATOM   4743 C  CG1 . VAL B 1 142 ? -81.176 -31.903 -34.775 1.00 56.54  ?  142 VAL B CG1 1 
ATOM   4744 C  CG2 . VAL B 1 142 ? -81.043 -34.195 -35.773 1.00 56.62  ?  142 VAL B CG2 1 
ATOM   4745 N  N   . GLU B 1 143 ? -84.779 -32.210 -34.065 1.00 56.59  ?  143 GLU B N   1 
ATOM   4746 C  CA  . GLU B 1 143 ? -85.684 -31.113 -33.615 1.00 56.62  ?  143 GLU B CA  1 
ATOM   4747 C  C   . GLU B 1 143 ? -86.287 -31.470 -32.251 1.00 56.44  ?  143 GLU B C   1 
ATOM   4748 O  O   . GLU B 1 143 ? -86.435 -30.552 -31.420 1.00 60.60  ?  143 GLU B O   1 
ATOM   4749 C  CB  . GLU B 1 143 ? -86.783 -30.837 -34.644 1.00 56.86  ?  143 GLU B CB  1 
ATOM   4750 N  N   . SER B 1 144 ? -86.624 -32.747 -32.040 1.00 54.01  ?  144 SER B N   1 
ATOM   4751 C  CA  . SER B 1 144 ? -87.220 -33.267 -30.776 1.00 53.71  ?  144 SER B CA  1 
ATOM   4752 C  C   . SER B 1 144 ? -86.184 -33.249 -29.640 1.00 53.87  ?  144 SER B C   1 
ATOM   4753 O  O   . SER B 1 144 ? -86.562 -32.932 -28.493 1.00 52.82  ?  144 SER B O   1 
ATOM   4754 C  CB  . SER B 1 144 ? -87.799 -34.647 -30.968 1.00 52.52  ?  144 SER B CB  1 
ATOM   4755 O  OG  . SER B 1 144 ? -88.515 -35.064 -29.814 1.00 50.98  ?  144 SER B OG  1 
ATOM   4756 N  N   . LEU B 1 145 ? -84.931 -33.598 -29.937 1.00 54.38  ?  145 LEU B N   1 
ATOM   4757 C  CA  . LEU B 1 145 ? -83.816 -33.574 -28.950 1.00 54.12  ?  145 LEU B CA  1 
ATOM   4758 C  C   . LEU B 1 145 ? -83.544 -32.119 -28.556 1.00 54.21  ?  145 LEU B C   1 
ATOM   4759 O  O   . LEU B 1 145 ? -83.536 -31.812 -27.349 1.00 53.66  ?  145 LEU B O   1 
ATOM   4760 C  CB  . LEU B 1 145 ? -82.575 -34.221 -29.574 1.00 52.08  ?  145 LEU B CB  1 
ATOM   4761 C  CG  . LEU B 1 145 ? -81.332 -34.258 -28.688 1.00 51.95  ?  145 LEU B CG  1 
ATOM   4762 C  CD1 . LEU B 1 145 ? -81.587 -35.060 -27.424 1.00 51.54  ?  145 LEU B CD1 1 
ATOM   4763 C  CD2 . LEU B 1 145 ? -80.141 -34.825 -29.444 1.00 52.57  ?  145 LEU B CD2 1 
ATOM   4764 N  N   . ILE B 1 146 ? -83.349 -31.266 -29.561 1.00 54.63  ?  146 ILE B N   1 
ATOM   4765 C  CA  . ILE B 1 146 ? -82.961 -29.833 -29.413 1.00 57.24  ?  146 ILE B CA  1 
ATOM   4766 C  C   . ILE B 1 146 ? -84.044 -29.078 -28.627 1.00 59.34  ?  146 ILE B C   1 
ATOM   4767 O  O   . ILE B 1 146 ? -83.694 -28.442 -27.610 1.00 59.85  ?  146 ILE B O   1 
ATOM   4768 C  CB  . ILE B 1 146 ? -82.667 -29.234 -30.803 1.00 59.93  ?  146 ILE B CB  1 
ATOM   4769 C  CG1 . ILE B 1 146 ? -81.231 -29.553 -31.227 1.00 62.81  ?  146 ILE B CG1 1 
ATOM   4770 C  CG2 . ILE B 1 146 ? -82.949 -27.743 -30.852 1.00 61.85  ?  146 ILE B CG2 1 
ATOM   4771 C  CD1 . ILE B 1 146 ? -80.908 -29.193 -32.662 1.00 65.15  ?  146 ILE B CD1 1 
ATOM   4772 N  N   . SER B 1 147 ? -85.306 -29.159 -29.058 1.00 59.28  ?  147 SER B N   1 
ATOM   4773 C  CA  . SER B 1 147 ? -86.441 -28.400 -28.457 1.00 59.17  ?  147 SER B CA  1 
ATOM   4774 C  C   . SER B 1 147 ? -86.634 -28.776 -26.980 1.00 57.66  ?  147 SER B C   1 
ATOM   4775 O  O   . SER B 1 147 ? -86.789 -27.856 -26.153 1.00 59.89  ?  147 SER B O   1 
ATOM   4776 C  CB  . SER B 1 147 ? -87.709 -28.601 -29.236 1.00 59.91  ?  147 SER B CB  1 
ATOM   4777 O  OG  . SER B 1 147 ? -88.083 -29.966 -29.231 1.00 63.89  ?  147 SER B OG  1 
ATOM   4778 N  N   . ARG B 1 148 ? -86.640 -30.071 -26.656 1.00 55.87  ?  148 ARG B N   1 
ATOM   4779 C  CA  . ARG B 1 148 ? -86.901 -30.551 -25.267 1.00 57.77  ?  148 ARG B CA  1 
ATOM   4780 C  C   . ARG B 1 148 ? -85.705 -30.253 -24.356 1.00 59.50  ?  148 ARG B C   1 
ATOM   4781 O  O   . ARG B 1 148 ? -85.916 -30.185 -23.126 1.00 58.65  ?  148 ARG B O   1 
ATOM   4782 C  CB  . ARG B 1 148 ? -87.221 -32.049 -25.237 1.00 58.13  ?  148 ARG B CB  1 
ATOM   4783 C  CG  . ARG B 1 148 ? -86.004 -32.961 -25.250 1.00 58.27  ?  148 ARG B CG  1 
ATOM   4784 C  CD  . ARG B 1 148 ? -86.408 -34.419 -25.168 1.00 60.87  ?  148 ARG B CD  1 
ATOM   4785 N  NE  . ARG B 1 148 ? -87.265 -34.813 -26.282 1.00 62.40  ?  148 ARG B NE  1 
ATOM   4786 C  CZ  . ARG B 1 148 ? -87.946 -35.950 -26.358 1.00 59.60  ?  148 ARG B CZ  1 
ATOM   4787 N  NH1 . ARG B 1 148 ? -87.882 -36.842 -25.383 1.00 58.75  ?  148 ARG B NH1 1 
ATOM   4788 N  NH2 . ARG B 1 148 ? -88.696 -36.188 -27.418 1.00 61.16  ?  148 ARG B NH2 1 
ATOM   4789 N  N   . THR B 1 149 ? -84.500 -30.116 -24.923 1.00 60.45  ?  149 THR B N   1 
ATOM   4790 C  CA  . THR B 1 149 ? -83.241 -29.931 -24.144 1.00 59.95  ?  149 THR B CA  1 
ATOM   4791 C  C   . THR B 1 149 ? -83.267 -28.558 -23.458 1.00 59.23  ?  149 THR B C   1 
ATOM   4792 O  O   . THR B 1 149 ? -83.002 -28.513 -22.244 1.00 61.37  ?  149 THR B O   1 
ATOM   4793 C  CB  . THR B 1 149 ? -82.003 -30.147 -25.023 1.00 60.60  ?  149 THR B CB  1 
ATOM   4794 O  OG1 . THR B 1 149 ? -81.922 -31.546 -25.293 1.00 59.18  ?  149 THR B OG1 1 
ATOM   4795 C  CG2 . THR B 1 149 ? -80.712 -29.684 -24.383 1.00 62.57  ?  149 THR B CG2 1 
ATOM   4796 N  N   . THR B 1 150 ? -83.571 -27.483 -24.194 1.00 58.12  ?  150 THR B N   1 
ATOM   4797 C  CA  . THR B 1 150 ? -83.610 -26.102 -23.636 1.00 59.36  ?  150 THR B CA  1 
ATOM   4798 C  C   . THR B 1 150 ? -84.586 -26.078 -22.458 1.00 59.64  ?  150 THR B C   1 
ATOM   4799 O  O   . THR B 1 150 ? -84.169 -25.641 -21.368 1.00 64.11  ?  150 THR B O   1 
ATOM   4800 C  CB  . THR B 1 150 ? -83.942 -25.049 -24.699 1.00 61.35  ?  150 THR B CB  1 
ATOM   4801 O  OG1 . THR B 1 150 ? -85.062 -25.510 -25.452 1.00 67.37  ?  150 THR B OG1 1 
ATOM   4802 C  CG2 . THR B 1 150 ? -82.781 -24.772 -25.629 1.00 61.42  ?  150 THR B CG2 1 
ATOM   4803 N  N   . ARG B 1 151 ? -85.816 -26.561 -22.666 1.00 59.86  ?  151 ARG B N   1 
ATOM   4804 C  CA  . ARG B 1 151 ? -86.873 -26.628 -21.612 1.00 59.63  ?  151 ARG B CA  1 
ATOM   4805 C  C   . ARG B 1 151 ? -86.367 -27.385 -20.379 1.00 57.43  ?  151 ARG B C   1 
ATOM   4806 O  O   . ARG B 1 151 ? -86.623 -26.919 -19.255 1.00 59.63  ?  151 ARG B O   1 
ATOM   4807 C  CB  . ARG B 1 151 ? -88.129 -27.339 -22.124 1.00 62.47  ?  151 ARG B CB  1 
ATOM   4808 C  CG  . ARG B 1 151 ? -88.987 -26.503 -23.060 1.00 66.01  ?  151 ARG B CG  1 
ATOM   4809 C  CD  . ARG B 1 151 ? -90.408 -27.029 -23.100 1.00 64.62  ?  151 ARG B CD  1 
ATOM   4810 N  NE  . ARG B 1 151 ? -90.436 -28.430 -23.487 1.00 61.54  ?  151 ARG B NE  1 
ATOM   4811 C  CZ  . ARG B 1 151 ? -90.431 -28.876 -24.740 1.00 60.68  ?  151 ARG B CZ  1 
ATOM   4812 N  NH1 . ARG B 1 151 ? -90.404 -28.034 -25.759 1.00 58.97  ?  151 ARG B NH1 1 
ATOM   4813 N  NH2 . ARG B 1 151 ? -90.467 -30.177 -24.969 1.00 63.13  ?  151 ARG B NH2 1 
ATOM   4814 N  N   . LEU B 1 152 ? -85.713 -28.527 -20.591 1.00 57.15  ?  152 LEU B N   1 
ATOM   4815 C  CA  . LEU B 1 152 ? -85.265 -29.450 -19.513 1.00 60.06  ?  152 LEU B CA  1 
ATOM   4816 C  C   . LEU B 1 152 ? -84.174 -28.770 -18.682 1.00 62.03  ?  152 LEU B C   1 
ATOM   4817 O  O   . LEU B 1 152 ? -84.255 -28.824 -17.436 1.00 62.37  ?  152 LEU B O   1 
ATOM   4818 C  CB  . LEU B 1 152 ? -84.741 -30.738 -20.153 1.00 61.91  ?  152 LEU B CB  1 
ATOM   4819 C  CG  . LEU B 1 152 ? -84.229 -31.800 -19.183 1.00 64.20  ?  152 LEU B CG  1 
ATOM   4820 C  CD1 . LEU B 1 152 ? -85.357 -32.325 -18.305 1.00 65.70  ?  152 LEU B CD1 1 
ATOM   4821 C  CD2 . LEU B 1 152 ? -83.571 -32.938 -19.945 1.00 65.82  ?  152 LEU B CD2 1 
ATOM   4822 N  N   . VAL B 1 153 ? -83.192 -28.167 -19.359 1.00 60.94  ?  153 VAL B N   1 
ATOM   4823 C  CA  . VAL B 1 153 ? -82.034 -27.472 -18.725 1.00 60.31  ?  153 VAL B CA  1 
ATOM   4824 C  C   . VAL B 1 153 ? -82.565 -26.266 -17.942 1.00 61.01  ?  153 VAL B C   1 
ATOM   4825 O  O   . VAL B 1 153 ? -82.161 -26.100 -16.776 1.00 62.76  ?  153 VAL B O   1 
ATOM   4826 C  CB  . VAL B 1 153 ? -80.983 -27.073 -19.778 1.00 60.30  ?  153 VAL B CB  1 
ATOM   4827 C  CG1 . VAL B 1 153 ? -79.929 -26.128 -19.216 1.00 60.44  ?  153 VAL B CG1 1 
ATOM   4828 C  CG2 . VAL B 1 153 ? -80.323 -28.302 -20.382 1.00 60.64  ?  153 VAL B CG2 1 
ATOM   4829 N  N   . LYS B 1 154 ? -83.452 -25.478 -18.552 1.00 60.56  ?  154 LYS B N   1 
ATOM   4830 C  CA  . LYS B 1 154 ? -84.066 -24.281 -17.917 1.00 62.47  ?  154 LYS B CA  1 
ATOM   4831 C  C   . LYS B 1 154 ? -84.860 -24.696 -16.674 1.00 63.99  ?  154 LYS B C   1 
ATOM   4832 O  O   . LYS B 1 154 ? -84.880 -23.920 -15.709 1.00 67.95  ?  154 LYS B O   1 
ATOM   4833 C  CB  . LYS B 1 154 ? -85.000 -23.547 -18.882 1.00 63.84  ?  154 LYS B CB  1 
ATOM   4834 C  CG  . LYS B 1 154 ? -85.362 -22.137 -18.437 1.00 66.53  ?  154 LYS B CG  1 
ATOM   4835 C  CD  . LYS B 1 154 ? -86.837 -21.809 -18.497 1.00 70.36  ?  154 LYS B CD  1 
ATOM   4836 C  CE  . LYS B 1 154 ? -87.234 -20.736 -17.504 1.00 75.19  ?  154 LYS B CE  1 
ATOM   4837 N  NZ  . LYS B 1 154 ? -86.979 -21.154 -16.101 1.00 76.80  ?  154 LYS B NZ  1 
ATOM   4838 N  N   . ALA B 1 155 ? -85.513 -25.858 -16.713 1.00 66.04  ?  155 ALA B N   1 
ATOM   4839 C  CA  . ALA B 1 155 ? -86.367 -26.370 -15.615 1.00 68.36  ?  155 ALA B CA  1 
ATOM   4840 C  C   . ALA B 1 155 ? -85.481 -26.903 -14.487 1.00 71.15  ?  155 ALA B C   1 
ATOM   4841 O  O   . ALA B 1 155 ? -85.784 -26.617 -13.312 1.00 75.29  ?  155 ALA B O   1 
ATOM   4842 C  CB  . ALA B 1 155 ? -87.302 -27.437 -16.128 1.00 66.65  ?  155 ALA B CB  1 
ATOM   4843 N  N   . THR B 1 156 ? -84.431 -27.652 -14.842 1.00 71.02  ?  156 THR B N   1 
ATOM   4844 C  CA  . THR B 1 156 ? -83.577 -28.406 -13.881 1.00 70.89  ?  156 THR B CA  1 
ATOM   4845 C  C   . THR B 1 156 ? -82.558 -27.473 -13.215 1.00 70.94  ?  156 THR B C   1 
ATOM   4846 O  O   . THR B 1 156 ? -82.437 -27.541 -11.980 1.00 72.83  ?  156 THR B O   1 
ATOM   4847 C  CB  . THR B 1 156 ? -82.891 -29.584 -14.579 1.00 72.27  ?  156 THR B CB  1 
ATOM   4848 O  OG1 . THR B 1 156 ? -83.920 -30.413 -15.119 1.00 71.66  ?  156 THR B OG1 1 
ATOM   4849 C  CG2 . THR B 1 156 ? -82.012 -30.400 -13.656 1.00 74.78  ?  156 THR B CG2 1 
ATOM   4850 N  N   . LEU B 1 157 ? -81.849 -26.654 -13.997 1.00 69.99  ?  157 LEU B N   1 
ATOM   4851 C  CA  . LEU B 1 157 ? -80.757 -25.770 -13.502 1.00 71.10  ?  157 LEU B CA  1 
ATOM   4852 C  C   . LEU B 1 157 ? -81.293 -24.364 -13.196 1.00 72.74  ?  157 LEU B C   1 
ATOM   4853 O  O   . LEU B 1 157 ? -80.557 -23.587 -12.556 1.00 80.86  ?  157 LEU B O   1 
ATOM   4854 C  CB  . LEU B 1 157 ? -79.635 -25.732 -14.544 1.00 70.00  ?  157 LEU B CB  1 
ATOM   4855 C  CG  . LEU B 1 157 ? -79.063 -27.092 -14.944 1.00 70.84  ?  157 LEU B CG  1 
ATOM   4856 C  CD1 . LEU B 1 157 ? -77.851 -26.923 -15.847 1.00 71.56  ?  157 LEU B CD1 1 
ATOM   4857 C  CD2 . LEU B 1 157 ? -78.700 -27.925 -13.724 1.00 70.46  ?  157 LEU B CD2 1 
ATOM   4858 N  N   . GLY B 1 158 ? -82.513 -24.045 -13.637 1.00 69.20  ?  158 GLY B N   1 
ATOM   4859 C  CA  . GLY B 1 158 ? -83.261 -22.846 -13.205 1.00 69.67  ?  158 GLY B CA  1 
ATOM   4860 C  C   . GLY B 1 158 ? -82.633 -21.549 -13.687 1.00 68.52  ?  158 GLY B C   1 
ATOM   4861 O  O   . GLY B 1 158 ? -82.557 -20.603 -12.887 1.00 73.31  ?  158 GLY B O   1 
ATOM   4862 N  N   . TYR B 1 159 ? -82.206 -21.496 -14.950 1.00 66.63  ?  159 TYR B N   1 
ATOM   4863 C  CA  . TYR B 1 159 ? -81.644 -20.278 -15.592 1.00 67.16  ?  159 TYR B CA  1 
ATOM   4864 C  C   . TYR B 1 159 ? -82.780 -19.480 -16.244 1.00 67.12  ?  159 TYR B C   1 
ATOM   4865 O  O   . TYR B 1 159 ? -83.800 -20.080 -16.621 1.00 68.88  ?  159 TYR B O   1 
ATOM   4866 C  CB  . TYR B 1 159 ? -80.539 -20.652 -16.584 1.00 67.50  ?  159 TYR B CB  1 
ATOM   4867 C  CG  . TYR B 1 159 ? -79.175 -20.824 -15.963 1.00 67.45  ?  159 TYR B CG  1 
ATOM   4868 C  CD1 . TYR B 1 159 ? -78.852 -21.956 -15.231 1.00 65.88  ?  159 TYR B CD1 1 
ATOM   4869 C  CD2 . TYR B 1 159 ? -78.199 -19.851 -16.114 1.00 67.76  ?  159 TYR B CD2 1 
ATOM   4870 C  CE1 . TYR B 1 159 ? -77.597 -22.114 -14.663 1.00 65.93  ?  159 TYR B CE1 1 
ATOM   4871 C  CE2 . TYR B 1 159 ? -76.940 -19.993 -15.551 1.00 65.52  ?  159 TYR B CE2 1 
ATOM   4872 C  CZ  . TYR B 1 159 ? -76.636 -21.129 -14.824 1.00 64.99  ?  159 TYR B CZ  1 
ATOM   4873 O  OH  . TYR B 1 159 ? -75.393 -21.262 -14.276 1.00 64.64  ?  159 TYR B OH  1 
ATOM   4874 N  N   . ASP B 1 160 ? -82.600 -18.163 -16.369 1.00 66.58  ?  160 ASP B N   1 
ATOM   4875 C  CA  . ASP B 1 160 ? -83.623 -17.222 -16.901 1.00 67.58  ?  160 ASP B CA  1 
ATOM   4876 C  C   . ASP B 1 160 ? -83.817 -17.488 -18.398 1.00 67.29  ?  160 ASP B C   1 
ATOM   4877 O  O   . ASP B 1 160 ? -84.946 -17.323 -18.889 1.00 71.93  ?  160 ASP B O   1 
ATOM   4878 C  CB  . ASP B 1 160 ? -83.236 -15.762 -16.642 1.00 68.10  ?  160 ASP B CB  1 
ATOM   4879 C  CG  . ASP B 1 160 ? -83.354 -15.324 -15.189 1.00 69.51  ?  160 ASP B CG  1 
ATOM   4880 O  OD1 . ASP B 1 160 ? -84.158 -15.931 -14.450 1.00 70.85  ?  160 ASP B OD1 1 
ATOM   4881 O  OD2 . ASP B 1 160 ? -82.644 -14.371 -14.809 1.00 72.10  ?  160 ASP B OD2 1 
ATOM   4882 N  N   . ARG B 1 161 ? -82.751 -17.882 -19.094 1.00 65.23  ?  161 ARG B N   1 
ATOM   4883 C  CA  . ARG B 1 161 ? -82.788 -18.179 -20.552 1.00 64.97  ?  161 ARG B CA  1 
ATOM   4884 C  C   . ARG B 1 161 ? -81.833 -19.339 -20.842 1.00 64.48  ?  161 ARG B C   1 
ATOM   4885 O  O   . ARG B 1 161 ? -80.713 -19.324 -20.304 1.00 65.73  ?  161 ARG B O   1 
ATOM   4886 C  CB  . ARG B 1 161 ? -82.412 -16.935 -21.361 1.00 65.14  ?  161 ARG B CB  1 
ATOM   4887 C  CG  . ARG B 1 161 ? -82.731 -17.030 -22.845 1.00 68.89  ?  161 ARG B CG  1 
ATOM   4888 C  CD  . ARG B 1 161 ? -81.866 -16.105 -23.677 1.00 76.10  ?  161 ARG B CD  1 
ATOM   4889 N  NE  . ARG B 1 161 ? -81.883 -14.730 -23.193 1.00 82.79  ?  161 ARG B NE  1 
ATOM   4890 C  CZ  . ARG B 1 161 ? -82.844 -13.845 -23.441 1.00 88.49  ?  161 ARG B CZ  1 
ATOM   4891 N  NH1 . ARG B 1 161 ? -83.895 -14.182 -24.172 1.00 92.04  ?  161 ARG B NH1 1 
ATOM   4892 N  NH2 . ARG B 1 161 ? -82.751 -12.617 -22.958 1.00 91.07  ?  161 ARG B NH2 1 
ATOM   4893 N  N   . VAL B 1 162 ? -82.279 -20.317 -21.632 1.00 60.63  ?  162 VAL B N   1 
ATOM   4894 C  CA  . VAL B 1 162 ? -81.417 -21.415 -22.158 1.00 58.33  ?  162 VAL B CA  1 
ATOM   4895 C  C   . VAL B 1 162 ? -81.536 -21.404 -23.681 1.00 57.88  ?  162 VAL B C   1 
ATOM   4896 O  O   . VAL B 1 162 ? -82.663 -21.499 -24.183 1.00 61.25  ?  162 VAL B O   1 
ATOM   4897 C  CB  . VAL B 1 162 ? -81.787 -22.787 -21.569 1.00 57.15  ?  162 VAL B CB  1 
ATOM   4898 C  CG1 . VAL B 1 162 ? -80.889 -23.887 -22.116 1.00 58.33  ?  162 VAL B CG1 1 
ATOM   4899 C  CG2 . VAL B 1 162 ? -81.742 -22.771 -20.051 1.00 56.33  ?  162 VAL B CG2 1 
ATOM   4900 N  N   . LEU B 1 163 ? -80.405 -21.261 -24.368 1.00 57.00  ?  163 LEU B N   1 
ATOM   4901 C  CA  . LEU B 1 163 ? -80.314 -21.252 -25.848 1.00 58.39  ?  163 LEU B CA  1 
ATOM   4902 C  C   . LEU B 1 163 ? -79.509 -22.470 -26.294 1.00 58.41  ?  163 LEU B C   1 
ATOM   4903 O  O   . LEU B 1 163 ? -78.695 -22.972 -25.491 1.00 59.88  ?  163 LEU B O   1 
ATOM   4904 C  CB  . LEU B 1 163 ? -79.633 -19.958 -26.305 1.00 60.49  ?  163 LEU B CB  1 
ATOM   4905 C  CG  . LEU B 1 163 ? -80.329 -18.665 -25.887 1.00 62.76  ?  163 LEU B CG  1 
ATOM   4906 C  CD1 . LEU B 1 163 ? -79.556 -17.459 -26.383 1.00 62.95  ?  163 LEU B CD1 1 
ATOM   4907 C  CD2 . LEU B 1 163 ? -81.763 -18.623 -26.396 1.00 65.03  ?  163 LEU B CD2 1 
ATOM   4908 N  N   . ILE B 1 164 ? -79.751 -22.935 -27.519 1.00 54.79  ?  164 ILE B N   1 
ATOM   4909 C  CA  . ILE B 1 164 ? -78.790 -23.797 -28.259 1.00 53.75  ?  164 ILE B CA  1 
ATOM   4910 C  C   . ILE B 1 164 ? -78.336 -23.014 -29.490 1.00 57.00  ?  164 ILE B C   1 
ATOM   4911 O  O   . ILE B 1 164 ? -79.199 -22.610 -30.305 1.00 57.48  ?  164 ILE B O   1 
ATOM   4912 C  CB  . ILE B 1 164 ? -79.372 -25.184 -28.586 1.00 51.60  ?  164 ILE B CB  1 
ATOM   4913 C  CG1 . ILE B 1 164 ? -79.601 -25.986 -27.300 1.00 50.54  ?  164 ILE B CG1 1 
ATOM   4914 C  CG2 . ILE B 1 164 ? -78.470 -25.927 -29.563 1.00 50.79  ?  164 ILE B CG2 1 
ATOM   4915 C  CD1 . ILE B 1 164 ? -80.240 -27.336 -27.503 1.00 51.05  ?  164 ILE B CD1 1 
ATOM   4916 N  N   . TYR B 1 165 ? -77.030 -22.743 -29.533 1.00 58.66  ?  165 TYR B N   1 
ATOM   4917 C  CA  A TYR B 1 165 ? -76.344 -22.099 -30.684 0.60 60.14  ?  165 TYR B CA  1 
ATOM   4918 C  CA  B TYR B 1 165 ? -76.295 -22.093 -30.647 0.40 59.62  ?  165 TYR B CA  1 
ATOM   4919 C  C   . TYR B 1 165 ? -75.791 -23.196 -31.588 1.00 59.19  ?  165 TYR B C   1 
ATOM   4920 O  O   . TYR B 1 165 ? -75.109 -24.097 -31.078 1.00 62.14  ?  165 TYR B O   1 
ATOM   4921 C  CB  A TYR B 1 165 ? -75.205 -21.177 -30.246 0.60 62.34  ?  165 TYR B CB  1 
ATOM   4922 C  CB  B TYR B 1 165 ? -75.136 -21.286 -30.047 0.40 61.04  ?  165 TYR B CB  1 
ATOM   4923 C  CG  A TYR B 1 165 ? -75.639 -20.016 -29.394 0.60 64.41  ?  165 TYR B CG  1 
ATOM   4924 C  CG  B TYR B 1 165 ? -74.846 -19.935 -30.649 0.40 62.44  ?  165 TYR B CG  1 
ATOM   4925 C  CD1 A TYR B 1 165 ? -76.656 -19.170 -29.800 0.60 67.68  ?  165 TYR B CD1 1 
ATOM   4926 C  CD1 B TYR B 1 165 ? -75.791 -18.923 -30.638 0.40 63.93  ?  165 TYR B CD1 1 
ATOM   4927 C  CD2 A TYR B 1 165 ? -75.030 -19.763 -28.179 0.60 66.80  ?  165 TYR B CD2 1 
ATOM   4928 C  CD2 B TYR B 1 165 ? -73.590 -19.643 -31.153 0.40 63.82  ?  165 TYR B CD2 1 
ATOM   4929 C  CE1 A TYR B 1 165 ? -77.064 -18.105 -29.015 0.60 70.30  ?  165 TYR B CE1 1 
ATOM   4930 C  CE1 B TYR B 1 165 ? -75.511 -17.670 -31.159 0.40 65.76  ?  165 TYR B CE1 1 
ATOM   4931 C  CE2 A TYR B 1 165 ? -75.430 -18.704 -27.383 0.60 69.35  ?  165 TYR B CE2 1 
ATOM   4932 C  CE2 B TYR B 1 165 ? -73.292 -18.396 -31.674 0.40 65.09  ?  165 TYR B CE2 1 
ATOM   4933 C  CZ  A TYR B 1 165 ? -76.449 -17.873 -27.802 0.60 70.63  ?  165 TYR B CZ  1 
ATOM   4934 C  CZ  B TYR B 1 165 ? -74.257 -17.405 -31.679 0.40 65.87  ?  165 TYR B CZ  1 
ATOM   4935 O  OH  A TYR B 1 165 ? -76.847 -16.831 -27.021 0.60 74.67  ?  165 TYR B OH  1 
ATOM   4936 O  OH  B TYR B 1 165 ? -73.966 -16.176 -32.195 0.40 66.88  ?  165 TYR B OH  1 
ATOM   4937 N  N   . ARG B 1 166 ? -76.113 -23.126 -32.877 1.00 55.96  ?  166 ARG B N   1 
ATOM   4938 C  CA  . ARG B 1 166 ? -75.533 -24.052 -33.885 1.00 56.76  ?  166 ARG B CA  1 
ATOM   4939 C  C   . ARG B 1 166 ? -74.612 -23.248 -34.805 1.00 54.88  ?  166 ARG B C   1 
ATOM   4940 O  O   . ARG B 1 166 ? -75.050 -22.203 -35.303 1.00 58.36  ?  166 ARG B O   1 
ATOM   4941 C  CB  . ARG B 1 166 ? -76.627 -24.758 -34.688 1.00 58.94  ?  166 ARG B CB  1 
ATOM   4942 C  CG  . ARG B 1 166 ? -76.100 -25.865 -35.591 1.00 60.83  ?  166 ARG B CG  1 
ATOM   4943 C  CD  . ARG B 1 166 ? -77.165 -26.361 -36.539 1.00 62.69  ?  166 ARG B CD  1 
ATOM   4944 N  NE  . ARG B 1 166 ? -77.522 -25.329 -37.503 1.00 66.07  ?  166 ARG B NE  1 
ATOM   4945 C  CZ  . ARG B 1 166 ? -78.681 -25.256 -38.151 1.00 68.92  ?  166 ARG B CZ  1 
ATOM   4946 N  NH1 . ARG B 1 166 ? -79.632 -26.152 -37.940 1.00 69.36  ?  166 ARG B NH1 1 
ATOM   4947 N  NH2 . ARG B 1 166 ? -78.890 -24.273 -39.010 1.00 72.24  ?  166 ARG B NH2 1 
ATOM   4948 N  N   . PHE B 1 167 ? -73.390 -23.726 -35.029 1.00 54.90  ?  167 PHE B N   1 
ATOM   4949 C  CA  . PHE B 1 167 ? -72.409 -23.083 -35.939 1.00 56.62  ?  167 PHE B CA  1 
ATOM   4950 C  C   . PHE B 1 167 ? -72.720 -23.497 -37.378 1.00 56.57  ?  167 PHE B C   1 
ATOM   4951 O  O   . PHE B 1 167 ? -72.911 -24.698 -37.620 1.00 58.94  ?  167 PHE B O   1 
ATOM   4952 C  CB  . PHE B 1 167 ? -70.980 -23.416 -35.506 1.00 57.45  ?  167 PHE B CB  1 
ATOM   4953 C  CG  . PHE B 1 167 ? -70.622 -22.848 -34.157 1.00 57.88  ?  167 PHE B CG  1 
ATOM   4954 C  CD1 . PHE B 1 167 ? -70.687 -21.482 -33.928 1.00 58.58  ?  167 PHE B CD1 1 
ATOM   4955 C  CD2 . PHE B 1 167 ? -70.244 -23.673 -33.111 1.00 58.06  ?  167 PHE B CD2 1 
ATOM   4956 C  CE1 . PHE B 1 167 ? -70.376 -20.956 -32.685 1.00 59.72  ?  167 PHE B CE1 1 
ATOM   4957 C  CE2 . PHE B 1 167 ? -69.929 -23.143 -31.869 1.00 59.37  ?  167 PHE B CE2 1 
ATOM   4958 C  CZ  . PHE B 1 167 ? -69.996 -21.787 -31.658 1.00 60.15  ?  167 PHE B CZ  1 
ATOM   4959 N  N   . GLU B 1 168 ? -72.803 -22.513 -38.280 1.00 59.11  ?  168 GLU B N   1 
ATOM   4960 C  CA  . GLU B 1 168 ? -72.945 -22.713 -39.747 1.00 63.35  ?  168 GLU B CA  1 
ATOM   4961 C  C   . GLU B 1 168 ? -71.557 -23.004 -40.330 1.00 64.60  ?  168 GLU B C   1 
ATOM   4962 O  O   . GLU B 1 168 ? -70.576 -22.930 -39.567 1.00 64.47  ?  168 GLU B O   1 
ATOM   4963 C  CB  . GLU B 1 168 ? -73.583 -21.484 -40.400 1.00 65.80  ?  168 GLU B CB  1 
ATOM   4964 C  CG  . GLU B 1 168 ? -74.950 -21.131 -39.837 1.00 68.09  ?  168 GLU B CG  1 
ATOM   4965 C  CD  . GLU B 1 168 ? -76.043 -22.158 -40.088 1.00 71.25  ?  168 GLU B CD  1 
ATOM   4966 O  OE1 . GLU B 1 168 ? -76.487 -22.276 -41.250 1.00 73.38  ?  168 GLU B OE1 1 
ATOM   4967 O  OE2 . GLU B 1 168 ? -76.448 -22.841 -39.120 1.00 71.00  ?  168 GLU B OE2 1 
ATOM   4968 N  N   . GLU B 1 169 ? -71.483 -23.321 -41.627 1.00 68.24  ?  169 GLU B N   1 
ATOM   4969 C  CA  . GLU B 1 169 ? -70.215 -23.659 -42.338 1.00 70.59  ?  169 GLU B CA  1 
ATOM   4970 C  C   . GLU B 1 169 ? -69.232 -22.482 -42.240 1.00 70.33  ?  169 GLU B C   1 
ATOM   4971 O  O   . GLU B 1 169 ? -68.021 -22.745 -42.161 1.00 72.86  ?  169 GLU B O   1 
ATOM   4972 C  CB  . GLU B 1 169 ? -70.490 -24.033 -43.798 1.00 69.85  ?  169 GLU B CB  1 
ATOM   4973 N  N   . ASP B 1 170 ? -69.737 -21.241 -42.228 1.00 70.67  ?  170 ASP B N   1 
ATOM   4974 C  CA  . ASP B 1 170 ? -68.919 -19.994 -42.263 1.00 69.67  ?  170 ASP B CA  1 
ATOM   4975 C  C   . ASP B 1 170 ? -68.446 -19.603 -40.854 1.00 67.58  ?  170 ASP B C   1 
ATOM   4976 O  O   . ASP B 1 170 ? -67.562 -18.730 -40.763 1.00 73.40  ?  170 ASP B O   1 
ATOM   4977 C  CB  . ASP B 1 170 ? -69.684 -18.839 -42.918 1.00 69.66  ?  170 ASP B CB  1 
ATOM   4978 C  CG  . ASP B 1 170 ? -70.962 -18.438 -42.203 1.00 71.93  ?  170 ASP B CG  1 
ATOM   4979 O  OD1 . ASP B 1 170 ? -71.226 -18.990 -41.118 1.00 73.10  ?  170 ASP B OD1 1 
ATOM   4980 O  OD2 . ASP B 1 170 ? -71.689 -17.578 -42.742 1.00 76.43  ?  170 ASP B OD2 1 
ATOM   4981 N  N   . GLY B 1 171 ? -69.013 -20.207 -39.804 1.00 60.53  ?  171 GLY B N   1 
ATOM   4982 C  CA  . GLY B 1 171 ? -68.673 -19.903 -38.399 1.00 58.51  ?  171 GLY B CA  1 
ATOM   4983 C  C   . GLY B 1 171 ? -69.806 -19.189 -37.686 1.00 58.08  ?  171 GLY B C   1 
ATOM   4984 O  O   . GLY B 1 171 ? -69.860 -19.255 -36.440 1.00 57.22  ?  171 GLY B O   1 
ATOM   4985 N  N   . ALA B 1 172 ? -70.684 -18.525 -38.443 1.00 57.53  ?  172 ALA B N   1 
ATOM   4986 C  CA  . ALA B 1 172 ? -71.889 -17.836 -37.927 1.00 57.26  ?  172 ALA B CA  1 
ATOM   4987 C  C   . ALA B 1 172 ? -72.674 -18.792 -37.022 1.00 56.48  ?  172 ALA B C   1 
ATOM   4988 O  O   . ALA B 1 172 ? -72.690 -20.002 -37.301 1.00 54.17  ?  172 ALA B O   1 
ATOM   4989 C  CB  . ALA B 1 172 ? -72.743 -17.340 -39.068 1.00 58.73  ?  172 ALA B CB  1 
ATOM   4990 N  N   . GLY B 1 173 ? -73.290 -18.256 -35.970 1.00 57.35  ?  173 GLY B N   1 
ATOM   4991 C  CA  . GLY B 1 173 ? -74.152 -19.015 -35.048 1.00 59.37  ?  173 GLY B CA  1 
ATOM   4992 C  C   . GLY B 1 173 ? -75.615 -18.788 -35.370 1.00 59.87  ?  173 GLY B C   1 
ATOM   4993 O  O   . GLY B 1 173 ? -75.940 -17.696 -35.852 1.00 61.16  ?  173 GLY B O   1 
ATOM   4994 N  N   . LYS B 1 174 ? -76.462 -19.791 -35.134 1.00 58.64  ?  174 LYS B N   1 
ATOM   4995 C  CA  . LYS B 1 174 ? -77.937 -19.668 -35.243 1.00 59.21  ?  174 LYS B CA  1 
ATOM   4996 C  C   . LYS B 1 174 ? -78.557 -20.131 -33.926 1.00 56.07  ?  174 LYS B C   1 
ATOM   4997 O  O   . LYS B 1 174 ? -78.097 -21.154 -33.387 1.00 55.45  ?  174 LYS B O   1 
ATOM   4998 C  CB  . LYS B 1 174 ? -78.470 -20.478 -36.428 1.00 63.37  ?  174 LYS B CB  1 
ATOM   4999 C  CG  . LYS B 1 174 ? -79.901 -20.145 -36.827 1.00 66.78  ?  174 LYS B CG  1 
ATOM   5000 C  CD  . LYS B 1 174 ? -80.503 -21.094 -37.835 1.00 69.00  ?  174 LYS B CD  1 
ATOM   5001 C  CE  . LYS B 1 174 ? -81.949 -20.765 -38.142 1.00 71.64  ?  174 LYS B CE  1 
ATOM   5002 N  NZ  . LYS B 1 174 ? -82.470 -21.566 -39.274 1.00 73.91  ?  174 LYS B NZ  1 
ATOM   5003 N  N   . VAL B 1 175 ? -79.542 -19.386 -33.422 1.00 55.83  ?  175 VAL B N   1 
ATOM   5004 C  CA  . VAL B 1 175 ? -80.352 -19.789 -32.236 1.00 56.63  ?  175 VAL B CA  1 
ATOM   5005 C  C   . VAL B 1 175 ? -81.459 -20.704 -32.754 1.00 57.27  ?  175 VAL B C   1 
ATOM   5006 O  O   . VAL B 1 175 ? -82.408 -20.184 -33.372 1.00 58.32  ?  175 VAL B O   1 
ATOM   5007 C  CB  . VAL B 1 175 ? -80.923 -18.579 -31.479 1.00 56.10  ?  175 VAL B CB  1 
ATOM   5008 C  CG1 . VAL B 1 175 ? -81.618 -19.003 -30.194 1.00 56.07  ?  175 VAL B CG1 1 
ATOM   5009 C  CG2 . VAL B 1 175 ? -79.849 -17.544 -31.193 1.00 55.61  ?  175 VAL B CG2 1 
ATOM   5010 N  N   . VAL B 1 176 ? -81.304 -22.014 -32.544 1.00 57.08  ?  176 VAL B N   1 
ATOM   5011 C  CA  . VAL B 1 176 ? -82.182 -23.075 -33.126 1.00 54.78  ?  176 VAL B CA  1 
ATOM   5012 C  C   . VAL B 1 176 ? -83.160 -23.580 -32.057 1.00 56.54  ?  176 VAL B C   1 
ATOM   5013 O  O   . VAL B 1 176 ? -84.070 -24.357 -32.408 1.00 59.44  ?  176 VAL B O   1 
ATOM   5014 C  CB  . VAL B 1 176 ? -81.347 -24.217 -33.734 1.00 52.14  ?  176 VAL B CB  1 
ATOM   5015 C  CG1 . VAL B 1 176 ? -80.550 -23.737 -34.934 1.00 51.02  ?  176 VAL B CG1 1 
ATOM   5016 C  CG2 . VAL B 1 176 ? -80.432 -24.879 -32.713 1.00 52.07  ?  176 VAL B CG2 1 
ATOM   5017 N  N   . SER B 1 177 ? -82.983 -23.156 -30.804 1.00 55.76  ?  177 SER B N   1 
ATOM   5018 C  CA  . SER B 1 177 ? -83.887 -23.498 -29.673 1.00 55.93  ?  177 SER B CA  1 
ATOM   5019 C  C   . SER B 1 177 ? -83.713 -22.464 -28.561 1.00 57.10  ?  177 SER B C   1 
ATOM   5020 O  O   . SER B 1 177 ? -82.620 -21.880 -28.464 1.00 56.91  ?  177 SER B O   1 
ATOM   5021 C  CB  . SER B 1 177 ? -83.631 -24.901 -29.177 1.00 55.95  ?  177 SER B CB  1 
ATOM   5022 O  OG  . SER B 1 177 ? -84.494 -25.241 -28.099 1.00 54.37  ?  177 SER B OG  1 
ATOM   5023 N  N   . GLU B 1 178 ? -84.761 -22.260 -27.761 1.00 59.39  ?  178 GLU B N   1 
ATOM   5024 C  CA  . GLU B 1 178 ? -84.823 -21.215 -26.708 1.00 58.77  ?  178 GLU B CA  1 
ATOM   5025 C  C   . GLU B 1 178 ? -85.867 -21.607 -25.661 1.00 57.89  ?  178 GLU B C   1 
ATOM   5026 O  O   . GLU B 1 178 ? -86.910 -22.166 -26.037 1.00 58.29  ?  178 GLU B O   1 
ATOM   5027 C  CB  . GLU B 1 178 ? -85.152 -19.862 -27.340 1.00 60.34  ?  178 GLU B CB  1 
ATOM   5028 C  CG  . GLU B 1 178 ? -85.272 -18.725 -26.339 1.00 62.00  ?  178 GLU B CG  1 
ATOM   5029 C  CD  . GLU B 1 178 ? -85.323 -17.355 -26.988 1.00 64.14  ?  178 GLU B CD  1 
ATOM   5030 O  OE1 . GLU B 1 178 ? -86.118 -17.186 -27.929 1.00 67.20  ?  178 GLU B OE1 1 
ATOM   5031 O  OE2 . GLU B 1 178 ? -84.552 -16.468 -26.574 1.00 69.50  ?  178 GLU B OE2 1 
ATOM   5032 N  N   . ALA B 1 179 ? -85.573 -21.323 -24.394 1.00 59.42  ?  179 ALA B N   1 
ATOM   5033 C  CA  . ALA B 1 179 ? -86.506 -21.442 -23.252 1.00 62.34  ?  179 ALA B CA  1 
ATOM   5034 C  C   . ALA B 1 179 ? -86.249 -20.267 -22.305 1.00 65.52  ?  179 ALA B C   1 
ATOM   5035 O  O   . ALA B 1 179 ? -85.438 -20.415 -21.376 1.00 69.73  ?  179 ALA B O   1 
ATOM   5036 C  CB  . ALA B 1 179 ? -86.336 -22.778 -22.567 1.00 61.35  ?  179 ALA B CB  1 
ATOM   5037 N  N   . LYS B 1 180 ? -86.913 -19.139 -22.561 1.00 69.49  ?  180 LYS B N   1 
ATOM   5038 C  CA  . LYS B 1 180 ? -86.708 -17.856 -21.836 1.00 71.21  ?  180 LYS B CA  1 
ATOM   5039 C  C   . LYS B 1 180 ? -87.830 -17.646 -20.815 1.00 73.51  ?  180 LYS B C   1 
ATOM   5040 O  O   . LYS B 1 180 ? -88.829 -18.387 -20.861 1.00 74.53  ?  180 LYS B O   1 
ATOM   5041 C  CB  . LYS B 1 180 ? -86.641 -16.691 -22.829 1.00 71.39  ?  180 LYS B CB  1 
ATOM   5042 C  CG  . LYS B 1 180 ? -87.884 -16.471 -23.678 1.00 74.31  ?  180 LYS B CG  1 
ATOM   5043 C  CD  . LYS B 1 180 ? -87.754 -15.291 -24.617 1.00 76.60  ?  180 LYS B CD  1 
ATOM   5044 C  CE  . LYS B 1 180 ? -89.036 -14.960 -25.353 1.00 78.38  ?  180 LYS B CE  1 
ATOM   5045 N  NZ  . LYS B 1 180 ? -90.149 -14.635 -24.427 1.00 79.85  ?  180 LYS B NZ  1 
ATOM   5046 N  N   . GLN B 1 181 ? -87.644 -16.681 -19.912 1.00 77.03  ?  181 GLN B N   1 
ATOM   5047 C  CA  . GLN B 1 181 ? -88.735 -16.100 -19.087 1.00 76.12  ?  181 GLN B CA  1 
ATOM   5048 C  C   . GLN B 1 181 ? -89.650 -15.320 -20.024 1.00 74.01  ?  181 GLN B C   1 
ATOM   5049 O  O   . GLN B 1 181 ? -89.177 -14.761 -21.011 1.00 70.35  ?  181 GLN B O   1 
ATOM   5050 C  CB  . GLN B 1 181 ? -88.188 -15.184 -17.989 1.00 79.11  ?  181 GLN B CB  1 
ATOM   5051 C  CG  . GLN B 1 181 ? -87.363 -15.900 -16.928 1.00 80.28  ?  181 GLN B CG  1 
ATOM   5052 C  CD  . GLN B 1 181 ? -88.182 -16.810 -16.045 1.00 84.04  ?  181 GLN B CD  1 
ATOM   5053 O  OE1 . GLN B 1 181 ? -89.110 -17.480 -16.492 1.00 84.12  ?  181 GLN B OE1 1 
ATOM   5054 N  NE2 . GLN B 1 181 ? -87.829 -16.857 -14.770 1.00 89.03  ?  181 GLN B NE2 1 
ATOM   5055 N  N   . PRO B 1 182 ? -90.976 -15.261 -19.754 1.00 74.01  ?  182 PRO B N   1 
ATOM   5056 C  CA  . PRO B 1 182 ? -91.904 -14.543 -20.630 1.00 71.84  ?  182 PRO B CA  1 
ATOM   5057 C  C   . PRO B 1 182 ? -91.483 -13.087 -20.890 1.00 71.31  ?  182 PRO B C   1 
ATOM   5058 O  O   . PRO B 1 182 ? -91.615 -12.632 -22.016 1.00 68.95  ?  182 PRO B O   1 
ATOM   5059 C  CB  . PRO B 1 182 ? -93.233 -14.589 -19.862 1.00 72.50  ?  182 PRO B CB  1 
ATOM   5060 C  CG  . PRO B 1 182 ? -93.114 -15.809 -18.968 1.00 71.64  ?  182 PRO B CG  1 
ATOM   5061 C  CD  . PRO B 1 182 ? -91.649 -15.882 -18.600 1.00 72.04  ?  182 PRO B CD  1 
ATOM   5062 N  N   . GLU B 1 183 ? -90.968 -12.414 -19.855 1.00 72.93  ?  183 GLU B N   1 
ATOM   5063 C  CA  . GLU B 1 183 ? -90.622 -10.964 -19.874 1.00 75.14  ?  183 GLU B CA  1 
ATOM   5064 C  C   . GLU B 1 183 ? -89.417 -10.700 -20.791 1.00 74.26  ?  183 GLU B C   1 
ATOM   5065 O  O   . GLU B 1 183 ? -89.355 -9.590  -21.356 1.00 75.26  ?  183 GLU B O   1 
ATOM   5066 C  CB  . GLU B 1 183 ? -90.363 -10.433 -18.460 1.00 76.89  ?  183 GLU B CB  1 
ATOM   5067 C  CG  . GLU B 1 183 ? -89.387 -11.259 -17.639 1.00 79.70  ?  183 GLU B CG  1 
ATOM   5068 C  CD  . GLU B 1 183 ? -90.026 -12.180 -16.610 1.00 83.18  ?  183 GLU B CD  1 
ATOM   5069 O  OE1 . GLU B 1 183 ? -91.052 -12.820 -16.938 1.00 82.86  ?  183 GLU B OE1 1 
ATOM   5070 O  OE2 . GLU B 1 183 ? -89.494 -12.258 -15.481 1.00 83.45  ?  183 GLU B OE2 1 
ATOM   5071 N  N   . LEU B 1 184 ? -88.501 -11.665 -20.937 1.00 72.36  ?  184 LEU B N   1 
ATOM   5072 C  CA  . LEU B 1 184 ? -87.282 -11.532 -21.786 1.00 69.82  ?  184 LEU B CA  1 
ATOM   5073 C  C   . LEU B 1 184 ? -87.669 -11.582 -23.265 1.00 69.70  ?  184 LEU B C   1 
ATOM   5074 O  O   . LEU B 1 184 ? -88.684 -12.219 -23.584 1.00 74.64  ?  184 LEU B O   1 
ATOM   5075 C  CB  . LEU B 1 184 ? -86.295 -12.656 -21.460 1.00 67.64  ?  184 LEU B CB  1 
ATOM   5076 C  CG  . LEU B 1 184 ? -85.681 -12.595 -20.066 1.00 66.94  ?  184 LEU B CG  1 
ATOM   5077 C  CD1 . LEU B 1 184 ? -84.918 -13.872 -19.762 1.00 67.49  ?  184 LEU B CD1 1 
ATOM   5078 C  CD2 . LEU B 1 184 ? -84.778 -11.382 -19.926 1.00 66.98  ?  184 LEU B CD2 1 
ATOM   5079 N  N   . GLU B 1 185 ? -86.876 -10.936 -24.123 1.00 71.19  ?  185 GLU B N   1 
ATOM   5080 C  CA  . GLU B 1 185 ? -87.053 -10.979 -25.599 1.00 75.34  ?  185 GLU B CA  1 
ATOM   5081 C  C   . GLU B 1 185 ? -86.538 -12.330 -26.108 1.00 77.03  ?  185 GLU B C   1 
ATOM   5082 O  O   . GLU B 1 185 ? -85.729 -12.964 -25.403 1.00 77.83  ?  185 GLU B O   1 
ATOM   5083 C  CB  . GLU B 1 185 ? -86.364 -9.793  -26.287 1.00 77.58  ?  185 GLU B CB  1 
ATOM   5084 C  CG  . GLU B 1 185 ? -84.851 -9.906  -26.416 1.00 77.58  ?  185 GLU B CG  1 
ATOM   5085 C  CD  . GLU B 1 185 ? -84.053 -9.359  -25.245 1.00 77.82  ?  185 GLU B CD  1 
ATOM   5086 O  OE1 . GLU B 1 185 ? -84.432 -9.630  -24.083 1.00 75.90  ?  185 GLU B OE1 1 
ATOM   5087 O  OE2 . GLU B 1 185 ? -83.053 -8.659  -25.500 1.00 75.50  ?  185 GLU B OE2 1 
ATOM   5088 N  N   . SER B 1 186 ? -87.009 -12.745 -27.284 1.00 76.05  ?  186 SER B N   1 
ATOM   5089 C  CA  . SER B 1 186 ? -86.624 -14.016 -27.959 1.00 72.12  ?  186 SER B CA  1 
ATOM   5090 C  C   . SER B 1 186 ? -85.453 -13.750 -28.912 1.00 71.15  ?  186 SER B C   1 
ATOM   5091 O  O   . SER B 1 186 ? -85.449 -12.678 -29.549 1.00 72.43  ?  186 SER B O   1 
ATOM   5092 C  CB  . SER B 1 186 ? -87.804 -14.623 -28.677 1.00 71.14  ?  186 SER B CB  1 
ATOM   5093 O  OG  . SER B 1 186 ? -87.388 -15.572 -29.648 1.00 74.51  ?  186 SER B OG  1 
ATOM   5094 N  N   . PHE B 1 187 ? -84.496 -14.681 -28.986 1.00 68.57  ?  187 PHE B N   1 
ATOM   5095 C  CA  . PHE B 1 187 ? -83.383 -14.682 -29.974 1.00 68.32  ?  187 PHE B CA  1 
ATOM   5096 C  C   . PHE B 1 187 ? -83.570 -15.824 -30.981 1.00 66.81  ?  187 PHE B C   1 
ATOM   5097 O  O   . PHE B 1 187 ? -82.672 -16.027 -31.825 1.00 62.62  ?  187 PHE B O   1 
ATOM   5098 C  CB  . PHE B 1 187 ? -82.034 -14.797 -29.263 1.00 67.78  ?  187 PHE B CB  1 
ATOM   5099 C  CG  . PHE B 1 187 ? -81.697 -13.626 -28.377 1.00 67.90  ?  187 PHE B CG  1 
ATOM   5100 C  CD1 . PHE B 1 187 ? -81.557 -12.356 -28.913 1.00 67.86  ?  187 PHE B CD1 1 
ATOM   5101 C  CD2 . PHE B 1 187 ? -81.507 -13.795 -27.014 1.00 67.96  ?  187 PHE B CD2 1 
ATOM   5102 C  CE1 . PHE B 1 187 ? -81.241 -11.276 -28.103 1.00 69.04  ?  187 PHE B CE1 1 
ATOM   5103 C  CE2 . PHE B 1 187 ? -81.191 -12.714 -26.205 1.00 69.43  ?  187 PHE B CE2 1 
ATOM   5104 C  CZ  . PHE B 1 187 ? -81.058 -11.458 -26.752 1.00 70.61  ?  187 PHE B CZ  1 
ATOM   5105 N  N   . LEU B 1 188 ? -84.706 -16.527 -30.905 1.00 64.28  ?  188 LEU B N   1 
ATOM   5106 C  CA  . LEU B 1 188 ? -84.992 -17.750 -31.704 1.00 64.61  ?  188 LEU B CA  1 
ATOM   5107 C  C   . LEU B 1 188 ? -85.042 -17.376 -33.188 1.00 62.91  ?  188 LEU B C   1 
ATOM   5108 O  O   . LEU B 1 188 ? -85.765 -16.429 -33.532 1.00 66.88  ?  188 LEU B O   1 
ATOM   5109 C  CB  . LEU B 1 188 ? -86.312 -18.364 -31.223 1.00 64.86  ?  188 LEU B CB  1 
ATOM   5110 C  CG  . LEU B 1 188 ? -86.709 -19.702 -31.849 1.00 63.89  ?  188 LEU B CG  1 
ATOM   5111 C  CD1 . LEU B 1 188 ? -85.607 -20.738 -31.696 1.00 64.25  ?  188 LEU B CD1 1 
ATOM   5112 C  CD2 . LEU B 1 188 ? -88.002 -20.215 -31.236 1.00 63.58  ?  188 LEU B CD2 1 
ATOM   5113 N  N   . GLY B 1 189 ? -84.268 -18.077 -34.019 1.00 63.29  ?  189 GLY B N   1 
ATOM   5114 C  CA  . GLY B 1 189 ? -84.183 -17.844 -35.474 1.00 65.43  ?  189 GLY B CA  1 
ATOM   5115 C  C   . GLY B 1 189 ? -83.129 -16.811 -35.833 1.00 66.11  ?  189 GLY B C   1 
ATOM   5116 O  O   . GLY B 1 189 ? -82.859 -16.646 -37.037 1.00 66.74  ?  189 GLY B O   1 
ATOM   5117 N  N   . GLN B 1 190 ? -82.541 -16.149 -34.832 1.00 68.85  ?  190 GLN B N   1 
ATOM   5118 C  CA  . GLN B 1 190 ? -81.556 -15.051 -35.019 1.00 72.34  ?  190 GLN B CA  1 
ATOM   5119 C  C   . GLN B 1 190 ? -80.164 -15.654 -35.237 1.00 69.96  ?  190 GLN B C   1 
ATOM   5120 O  O   . GLN B 1 190 ? -79.851 -16.675 -34.595 1.00 71.32  ?  190 GLN B O   1 
ATOM   5121 C  CB  . GLN B 1 190 ? -81.576 -14.123 -33.804 1.00 78.49  ?  190 GLN B CB  1 
ATOM   5122 C  CG  . GLN B 1 190 ? -81.133 -12.699 -34.103 1.00 82.98  ?  190 GLN B CG  1 
ATOM   5123 C  CD  . GLN B 1 190 ? -81.318 -11.807 -32.898 1.00 87.43  ?  190 GLN B CD  1 
ATOM   5124 O  OE1 . GLN B 1 190 ? -82.369 -11.809 -32.260 1.00 82.81  ?  190 GLN B OE1 1 
ATOM   5125 N  NE2 . GLN B 1 190 ? -80.290 -11.040 -32.570 1.00 91.88  ?  190 GLN B NE2 1 
ATOM   5126 N  N   . TYR B 1 191 ? -79.371 -15.040 -36.116 1.00 66.52  ?  191 TYR B N   1 
ATOM   5127 C  CA  . TYR B 1 191 ? -77.961 -15.413 -36.398 1.00 66.97  ?  191 TYR B CA  1 
ATOM   5128 C  C   . TYR B 1 191 ? -77.011 -14.375 -35.795 1.00 67.77  ?  191 TYR B C   1 
ATOM   5129 O  O   . TYR B 1 191 ? -77.390 -13.196 -35.698 1.00 72.76  ?  191 TYR B O   1 
ATOM   5130 C  CB  . TYR B 1 191 ? -77.682 -15.462 -37.902 1.00 67.75  ?  191 TYR B CB  1 
ATOM   5131 C  CG  . TYR B 1 191 ? -78.343 -16.580 -38.667 1.00 68.54  ?  191 TYR B CG  1 
ATOM   5132 C  CD1 . TYR B 1 191 ? -79.706 -16.568 -38.923 1.00 68.31  ?  191 TYR B CD1 1 
ATOM   5133 C  CD2 . TYR B 1 191 ? -77.596 -17.628 -39.180 1.00 69.05  ?  191 TYR B CD2 1 
ATOM   5134 C  CE1 . TYR B 1 191 ? -80.313 -17.585 -39.643 1.00 68.27  ?  191 TYR B CE1 1 
ATOM   5135 C  CE2 . TYR B 1 191 ? -78.187 -18.649 -39.906 1.00 69.17  ?  191 TYR B CE2 1 
ATOM   5136 C  CZ  . TYR B 1 191 ? -79.550 -18.626 -40.140 1.00 68.80  ?  191 TYR B CZ  1 
ATOM   5137 O  OH  . TYR B 1 191 ? -80.130 -19.631 -40.856 1.00 70.58  ?  191 TYR B OH  1 
ATOM   5138 N  N   . PHE B 1 192 ? -75.808 -14.816 -35.418 1.00 67.31  ?  192 PHE B N   1 
ATOM   5139 C  CA  A PHE B 1 192 ? -74.674 -13.935 -35.027 0.60 64.88  ?  192 PHE B CA  1 
ATOM   5140 C  CA  B PHE B 1 192 ? -74.674 -13.940 -35.022 0.40 65.32  ?  192 PHE B CA  1 
ATOM   5141 C  C   . PHE B 1 192 ? -73.483 -14.279 -35.915 1.00 64.72  ?  192 PHE B C   1 
ATOM   5142 O  O   . PHE B 1 192 ? -73.351 -15.416 -36.359 1.00 66.46  ?  192 PHE B O   1 
ATOM   5143 C  CB  A PHE B 1 192 ? -74.362 -14.035 -33.529 0.60 64.67  ?  192 PHE B CB  1 
ATOM   5144 C  CB  B PHE B 1 192 ? -74.408 -14.098 -33.524 0.40 65.26  ?  192 PHE B CB  1 
ATOM   5145 C  CG  A PHE B 1 192 ? -73.716 -15.313 -33.048 0.60 64.85  ?  192 PHE B CG  1 
ATOM   5146 C  CG  B PHE B 1 192 ? -75.617 -13.813 -32.667 0.40 65.33  ?  192 PHE B CG  1 
ATOM   5147 C  CD1 A PHE B 1 192 ? -72.455 -15.695 -33.484 0.60 64.14  ?  192 PHE B CD1 1 
ATOM   5148 C  CD1 B PHE B 1 192 ? -76.626 -14.753 -32.525 0.40 65.33  ?  192 PHE B CD1 1 
ATOM   5149 C  CD2 A PHE B 1 192 ? -74.346 -16.105 -32.099 0.60 65.05  ?  192 PHE B CD2 1 
ATOM   5150 C  CD2 B PHE B 1 192 ? -75.761 -12.593 -32.026 0.40 65.61  ?  192 PHE B CD2 1 
ATOM   5151 C  CE1 A PHE B 1 192 ? -71.861 -16.858 -33.020 0.60 62.80  ?  192 PHE B CE1 1 
ATOM   5152 C  CE1 B PHE B 1 192 ? -77.745 -14.485 -31.752 0.40 66.10  ?  192 PHE B CE1 1 
ATOM   5153 C  CE2 A PHE B 1 192 ? -73.749 -17.266 -31.632 0.60 63.78  ?  192 PHE B CE2 1 
ATOM   5154 C  CE2 B PHE B 1 192 ? -76.879 -12.327 -31.250 0.40 66.89  ?  192 PHE B CE2 1 
ATOM   5155 C  CZ  A PHE B 1 192 ? -72.509 -17.640 -32.092 0.60 63.18  ?  192 PHE B CZ  1 
ATOM   5156 C  CZ  B PHE B 1 192 ? -77.868 -13.273 -31.115 0.40 67.02  ?  192 PHE B CZ  1 
ATOM   5157 N  N   . PRO B 1 193 ? -72.584 -13.312 -36.215 1.00 64.79  ?  193 PRO B N   1 
ATOM   5158 C  CA  . PRO B 1 193 ? -71.466 -13.570 -37.123 1.00 62.72  ?  193 PRO B CA  1 
ATOM   5159 C  C   . PRO B 1 193 ? -70.313 -14.314 -36.433 1.00 60.91  ?  193 PRO B C   1 
ATOM   5160 O  O   . PRO B 1 193 ? -70.208 -14.243 -35.227 1.00 57.15  ?  193 PRO B O   1 
ATOM   5161 C  CB  . PRO B 1 193 ? -71.055 -12.160 -37.560 1.00 62.20  ?  193 PRO B CB  1 
ATOM   5162 C  CG  . PRO B 1 193 ? -71.357 -11.307 -36.346 1.00 64.53  ?  193 PRO B CG  1 
ATOM   5163 C  CD  . PRO B 1 193 ? -72.585 -11.930 -35.710 1.00 64.30  ?  193 PRO B CD  1 
ATOM   5164 N  N   . ALA B 1 194 ? -69.486 -15.002 -37.226 1.00 62.19  ?  194 ALA B N   1 
ATOM   5165 C  CA  . ALA B 1 194 ? -68.344 -15.828 -36.766 1.00 64.73  ?  194 ALA B CA  1 
ATOM   5166 C  C   . ALA B 1 194 ? -67.479 -15.031 -35.783 1.00 66.73  ?  194 ALA B C   1 
ATOM   5167 O  O   . ALA B 1 194 ? -67.049 -15.609 -34.763 1.00 66.40  ?  194 ALA B O   1 
ATOM   5168 C  CB  . ALA B 1 194 ? -67.537 -16.295 -37.952 1.00 64.58  ?  194 ALA B CB  1 
ATOM   5169 N  N   . SER B 1 195 ? -67.252 -13.749 -36.088 1.00 70.23  ?  195 SER B N   1 
ATOM   5170 C  CA  . SER B 1 195 ? -66.390 -12.815 -35.308 1.00 70.06  ?  195 SER B CA  1 
ATOM   5171 C  C   . SER B 1 195 ? -66.878 -12.682 -33.857 1.00 67.24  ?  195 SER B C   1 
ATOM   5172 O  O   . SER B 1 195 ? -66.031 -12.416 -32.988 1.00 70.34  ?  195 SER B O   1 
ATOM   5173 C  CB  . SER B 1 195 ? -66.295 -11.469 -35.984 1.00 71.50  ?  195 SER B CB  1 
ATOM   5174 O  OG  . SER B 1 195 ? -67.578 -10.888 -36.152 1.00 73.86  ?  195 SER B OG  1 
ATOM   5175 N  N   . ASP B 1 196 ? -68.177 -12.869 -33.598 1.00 66.71  ?  196 ASP B N   1 
ATOM   5176 C  CA  . ASP B 1 196 ? -68.784 -12.752 -32.241 1.00 66.26  ?  196 ASP B CA  1 
ATOM   5177 C  C   . ASP B 1 196 ? -68.227 -13.834 -31.307 1.00 63.30  ?  196 ASP B C   1 
ATOM   5178 O  O   . ASP B 1 196 ? -68.405 -13.693 -30.085 1.00 59.89  ?  196 ASP B O   1 
ATOM   5179 C  CB  . ASP B 1 196 ? -70.315 -12.811 -32.281 1.00 68.34  ?  196 ASP B CB  1 
ATOM   5180 C  CG  . ASP B 1 196 ? -70.977 -11.472 -32.556 1.00 70.16  ?  196 ASP B CG  1 
ATOM   5181 O  OD1 . ASP B 1 196 ? -70.342 -10.626 -33.217 1.00 74.19  ?  196 ASP B OD1 1 
ATOM   5182 O  OD2 . ASP B 1 196 ? -72.119 -11.282 -32.096 1.00 70.77  ?  196 ASP B OD2 1 
ATOM   5183 N  N   . ILE B 1 197 ? -67.610 -14.885 -31.853 1.00 64.16  ?  197 ILE B N   1 
ATOM   5184 C  CA  . ILE B 1 197 ? -66.898 -15.929 -31.056 1.00 65.08  ?  197 ILE B CA  1 
ATOM   5185 C  C   . ILE B 1 197 ? -65.587 -16.244 -31.763 1.00 66.17  ?  197 ILE B C   1 
ATOM   5186 O  O   . ILE B 1 197 ? -65.529 -17.167 -32.568 1.00 69.17  ?  197 ILE B O   1 
ATOM   5187 C  CB  . ILE B 1 197 ? -67.762 -17.189 -30.860 1.00 65.89  ?  197 ILE B CB  1 
ATOM   5188 C  CG1 . ILE B 1 197 ? -69.157 -16.844 -30.329 1.00 66.85  ?  197 ILE B CG1 1 
ATOM   5189 C  CG2 . ILE B 1 197 ? -67.041 -18.185 -29.964 1.00 68.32  ?  197 ILE B CG2 1 
ATOM   5190 C  CD1 . ILE B 1 197 ? -69.988 -18.046 -29.938 1.00 68.79  ?  197 ILE B CD1 1 
ATOM   5191 N  N   . PRO B 1 198 ? -64.499 -15.493 -31.481 1.00 68.95  ?  198 PRO B N   1 
ATOM   5192 C  CA  . PRO B 1 198 ? -63.255 -15.629 -32.239 1.00 70.93  ?  198 PRO B CA  1 
ATOM   5193 C  C   . PRO B 1 198 ? -62.587 -17.001 -32.044 1.00 71.31  ?  198 PRO B C   1 
ATOM   5194 O  O   . PRO B 1 198 ? -62.962 -17.715 -31.129 1.00 69.28  ?  198 PRO B O   1 
ATOM   5195 C  CB  . PRO B 1 198 ? -62.378 -14.488 -31.700 1.00 71.53  ?  198 PRO B CB  1 
ATOM   5196 C  CG  . PRO B 1 198 ? -62.920 -14.221 -30.310 1.00 71.04  ?  198 PRO B CG  1 
ATOM   5197 C  CD  . PRO B 1 198 ? -64.406 -14.484 -30.414 1.00 69.27  ?  198 PRO B CD  1 
ATOM   5198 N  N   . GLN B 1 199 ? -61.617 -17.320 -32.907 1.00 73.96  ?  199 GLN B N   1 
ATOM   5199 C  CA  . GLN B 1 199 ? -60.993 -18.667 -33.035 1.00 78.02  ?  199 GLN B CA  1 
ATOM   5200 C  C   . GLN B 1 199 ? -60.420 -19.133 -31.691 1.00 74.39  ?  199 GLN B C   1 
ATOM   5201 O  O   . GLN B 1 199 ? -60.601 -20.322 -31.368 1.00 71.72  ?  199 GLN B O   1 
ATOM   5202 C  CB  . GLN B 1 199 ? -59.919 -18.657 -34.126 1.00 83.98  ?  199 GLN B CB  1 
ATOM   5203 C  CG  . GLN B 1 199 ? -60.496 -18.617 -35.536 1.00 90.14  ?  199 GLN B CG  1 
ATOM   5204 C  CD  . GLN B 1 199 ? -61.384 -19.804 -35.831 1.00 96.57  ?  199 GLN B CD  1 
ATOM   5205 O  OE1 . GLN B 1 199 ? -60.952 -20.956 -35.777 1.00 97.64  ?  199 GLN B OE1 1 
ATOM   5206 N  NE2 . GLN B 1 199 ? -62.645 -19.536 -36.140 1.00 97.41  ?  199 GLN B NE2 1 
ATOM   5207 N  N   . GLN B 1 200 ? -59.764 -18.241 -30.943 1.00 74.68  ?  200 GLN B N   1 
ATOM   5208 C  CA  . GLN B 1 200 ? -59.126 -18.561 -29.634 1.00 77.95  ?  200 GLN B CA  1 
ATOM   5209 C  C   . GLN B 1 200 ? -60.176 -19.158 -28.686 1.00 73.66  ?  200 GLN B C   1 
ATOM   5210 O  O   . GLN B 1 200 ? -59.835 -20.107 -27.956 1.00 72.98  ?  200 GLN B O   1 
ATOM   5211 C  CB  . GLN B 1 200 ? -58.466 -17.311 -29.041 1.00 85.22  ?  200 GLN B CB  1 
ATOM   5212 C  CG  . GLN B 1 200 ? -57.825 -17.528 -27.673 1.00 93.20  ?  200 GLN B CG  1 
ATOM   5213 C  CD  . GLN B 1 200 ? -56.560 -18.353 -27.718 1.00 98.47  ?  200 GLN B CD  1 
ATOM   5214 O  OE1 . GLN B 1 200 ? -56.523 -19.497 -27.263 1.00 97.64  ?  200 GLN B OE1 1 
ATOM   5215 N  NE2 . GLN B 1 200 ? -55.504 -17.769 -28.262 1.00 101.22 ?  200 GLN B NE2 1 
ATOM   5216 N  N   . ALA B 1 201 ? -61.400 -18.621 -28.700 1.00 70.74  ?  201 ALA B N   1 
ATOM   5217 C  CA  . ALA B 1 201 ? -62.520 -19.026 -27.815 1.00 67.83  ?  201 ALA B CA  1 
ATOM   5218 C  C   . ALA B 1 201 ? -63.048 -20.400 -28.241 1.00 65.82  ?  201 ALA B C   1 
ATOM   5219 O  O   . ALA B 1 201 ? -63.163 -21.283 -27.367 1.00 65.52  ?  201 ALA B O   1 
ATOM   5220 C  CB  . ALA B 1 201 ? -63.610 -17.983 -27.838 1.00 67.99  ?  201 ALA B CB  1 
ATOM   5221 N  N   . ARG B 1 202 ? -63.372 -20.560 -29.528 1.00 63.77  ?  202 ARG B N   1 
ATOM   5222 C  CA  . ARG B 1 202 ? -63.862 -21.845 -30.103 1.00 64.07  ?  202 ARG B CA  1 
ATOM   5223 C  C   . ARG B 1 202 ? -62.937 -22.983 -29.665 1.00 63.63  ?  202 ARG B C   1 
ATOM   5224 O  O   . ARG B 1 202 ? -63.457 -24.015 -29.201 1.00 67.90  ?  202 ARG B O   1 
ATOM   5225 C  CB  . ARG B 1 202 ? -63.941 -21.778 -31.629 1.00 65.57  ?  202 ARG B CB  1 
ATOM   5226 C  CG  . ARG B 1 202 ? -65.115 -20.960 -32.143 1.00 66.47  ?  202 ARG B CG  1 
ATOM   5227 C  CD  . ARG B 1 202 ? -64.881 -20.426 -33.541 1.00 69.98  ?  202 ARG B CD  1 
ATOM   5228 N  NE  . ARG B 1 202 ? -65.854 -19.387 -33.859 1.00 74.49  ?  202 ARG B NE  1 
ATOM   5229 C  CZ  . ARG B 1 202 ? -67.011 -19.575 -34.489 1.00 76.46  ?  202 ARG B CZ  1 
ATOM   5230 N  NH1 . ARG B 1 202 ? -67.368 -20.778 -34.908 1.00 79.88  ?  202 ARG B NH1 1 
ATOM   5231 N  NH2 . ARG B 1 202 ? -67.809 -18.545 -34.704 1.00 77.11  ?  202 ARG B NH2 1 
ATOM   5232 N  N   . ALA B 1 203 ? -61.623 -22.778 -29.797 1.00 62.64  ?  203 ALA B N   1 
ATOM   5233 C  CA  . ALA B 1 203 ? -60.556 -23.736 -29.413 1.00 63.16  ?  203 ALA B CA  1 
ATOM   5234 C  C   . ALA B 1 203 ? -60.691 -24.106 -27.931 1.00 64.61  ?  203 ALA B C   1 
ATOM   5235 O  O   . ALA B 1 203 ? -60.651 -25.308 -27.614 1.00 65.88  ?  203 ALA B O   1 
ATOM   5236 C  CB  . ALA B 1 203 ? -59.198 -23.147 -29.706 1.00 61.45  ?  203 ALA B CB  1 
ATOM   5237 N  N   . LEU B 1 204 ? -60.843 -23.108 -27.058 1.00 65.25  ?  204 LEU B N   1 
ATOM   5238 C  CA  . LEU B 1 204 ? -60.985 -23.321 -25.591 1.00 68.97  ?  204 LEU B CA  1 
ATOM   5239 C  C   . LEU B 1 204 ? -62.249 -24.137 -25.297 1.00 68.77  ?  204 LEU B C   1 
ATOM   5240 O  O   . LEU B 1 204 ? -62.190 -24.982 -24.381 1.00 71.79  ?  204 LEU B O   1 
ATOM   5241 C  CB  . LEU B 1 204 ? -61.029 -21.973 -24.860 1.00 70.62  ?  204 LEU B CB  1 
ATOM   5242 C  CG  . LEU B 1 204 ? -59.706 -21.493 -24.268 1.00 72.06  ?  204 LEU B CG  1 
ATOM   5243 C  CD1 . LEU B 1 204 ? -59.891 -20.162 -23.561 1.00 74.60  ?  204 LEU B CD1 1 
ATOM   5244 C  CD2 . LEU B 1 204 ? -59.126 -22.520 -23.306 1.00 73.15  ?  204 LEU B CD2 1 
ATOM   5245 N  N   . TYR B 1 205 ? -63.336 -23.892 -26.042 1.00 67.95  ?  205 TYR B N   1 
ATOM   5246 C  CA  A TYR B 1 205 ? -64.647 -24.548 -25.785 0.40 67.06  ?  205 TYR B CA  1 
ATOM   5247 C  CA  B TYR B 1 205 ? -64.675 -24.530 -25.875 0.60 66.78  ?  205 TYR B CA  1 
ATOM   5248 C  C   . TYR B 1 205 ? -64.592 -26.003 -26.284 1.00 65.02  ?  205 TYR B C   1 
ATOM   5249 O  O   . TYR B 1 205 ? -65.404 -26.817 -25.814 1.00 61.13  ?  205 TYR B O   1 
ATOM   5250 C  CB  A TYR B 1 205 ? -65.775 -23.669 -26.332 0.40 67.03  ?  205 TYR B CB  1 
ATOM   5251 C  CB  B TYR B 1 205 ? -65.755 -23.864 -26.741 0.60 65.93  ?  205 TYR B CB  1 
ATOM   5252 C  CG  A TYR B 1 205 ? -65.698 -22.251 -25.820 0.40 66.92  ?  205 TYR B CG  1 
ATOM   5253 C  CG  B TYR B 1 205 ? -66.386 -22.608 -26.189 0.60 64.81  ?  205 TYR B CG  1 
ATOM   5254 C  CD1 A TYR B 1 205 ? -65.031 -21.966 -24.639 0.40 66.47  ?  205 TYR B CD1 1 
ATOM   5255 C  CD1 B TYR B 1 205 ? -66.903 -22.561 -24.904 0.60 65.50  ?  205 TYR B CD1 1 
ATOM   5256 C  CD2 A TYR B 1 205 ? -66.264 -21.194 -26.513 0.40 67.49  ?  205 TYR B CD2 1 
ATOM   5257 C  CD2 B TYR B 1 205 ? -66.516 -21.473 -26.977 0.60 64.76  ?  205 TYR B CD2 1 
ATOM   5258 C  CE1 A TYR B 1 205 ? -64.928 -20.672 -24.157 0.40 66.38  ?  205 TYR B CE1 1 
ATOM   5259 C  CE1 B TYR B 1 205 ? -67.493 -21.412 -24.402 0.60 65.68  ?  205 TYR B CE1 1 
ATOM   5260 C  CE2 A TYR B 1 205 ? -66.175 -19.893 -26.043 0.40 67.17  ?  205 TYR B CE2 1 
ATOM   5261 C  CE2 B TYR B 1 205 ? -67.102 -20.315 -26.491 0.60 64.47  ?  205 TYR B CE2 1 
ATOM   5262 C  CZ  A TYR B 1 205 ? -65.503 -19.632 -24.862 0.40 66.39  ?  205 TYR B CZ  1 
ATOM   5263 C  CZ  B TYR B 1 205 ? -67.594 -20.284 -25.199 0.60 65.45  ?  205 TYR B CZ  1 
ATOM   5264 O  OH  A TYR B 1 205 ? -65.409 -18.357 -24.387 0.40 66.90  ?  205 TYR B OH  1 
ATOM   5265 O  OH  B TYR B 1 205 ? -68.167 -19.148 -24.707 0.60 64.13  ?  205 TYR B OH  1 
ATOM   5266 N  N   . LEU B 1 206 ? -63.638 -26.314 -27.162 1.00 65.29  ?  206 LEU B N   1 
ATOM   5267 C  CA  . LEU B 1 206 ? -63.356 -27.686 -27.663 1.00 68.65  ?  206 LEU B CA  1 
ATOM   5268 C  C   . LEU B 1 206 ? -62.558 -28.459 -26.603 1.00 70.99  ?  206 LEU B C   1 
ATOM   5269 O  O   . LEU B 1 206 ? -62.652 -29.700 -26.585 1.00 69.98  ?  206 LEU B O   1 
ATOM   5270 C  CB  . LEU B 1 206 ? -62.573 -27.555 -28.974 1.00 72.29  ?  206 LEU B CB  1 
ATOM   5271 C  CG  . LEU B 1 206 ? -62.525 -28.792 -29.865 1.00 76.01  ?  206 LEU B CG  1 
ATOM   5272 C  CD1 . LEU B 1 206 ? -63.888 -29.080 -30.476 1.00 77.86  ?  206 LEU B CD1 1 
ATOM   5273 C  CD2 . LEU B 1 206 ? -61.483 -28.612 -30.960 1.00 79.11  ?  206 LEU B CD2 1 
ATOM   5274 N  N   . LYS B 1 207 ? -61.806 -27.738 -25.759 1.00 74.09  ?  207 LYS B N   1 
ATOM   5275 C  CA  . LYS B 1 207 ? -60.919 -28.289 -24.695 1.00 73.79  ?  207 LYS B CA  1 
ATOM   5276 C  C   . LYS B 1 207 ? -61.666 -28.360 -23.360 1.00 70.87  ?  207 LYS B C   1 
ATOM   5277 O  O   . LYS B 1 207 ? -61.407 -29.308 -22.604 1.00 71.96  ?  207 LYS B O   1 
ATOM   5278 C  CB  . LYS B 1 207 ? -59.672 -27.417 -24.520 1.00 78.20  ?  207 LYS B CB  1 
ATOM   5279 C  CG  . LYS B 1 207 ? -58.658 -27.489 -25.653 1.00 82.35  ?  207 LYS B CG  1 
ATOM   5280 C  CD  . LYS B 1 207 ? -57.463 -26.583 -25.441 1.00 84.79  ?  207 LYS B CD  1 
ATOM   5281 C  CE  . LYS B 1 207 ? -56.477 -26.625 -26.589 1.00 88.35  ?  207 LYS B CE  1 
ATOM   5282 N  NZ  . LYS B 1 207 ? -55.352 -25.685 -26.373 1.00 90.83  ?  207 LYS B NZ  1 
ATOM   5283 N  N   . ASN B 1 208 ? -62.512 -27.366 -23.071 1.00 72.23  ?  208 ASN B N   1 
ATOM   5284 C  CA  . ASN B 1 208 ? -63.404 -27.325 -21.879 1.00 75.12  ?  208 ASN B CA  1 
ATOM   5285 C  C   . ASN B 1 208 ? -64.853 -27.516 -22.323 1.00 73.34  ?  208 ASN B C   1 
ATOM   5286 O  O   . ASN B 1 208 ? -65.334 -26.672 -23.096 1.00 76.84  ?  208 ASN B O   1 
ATOM   5287 C  CB  . ASN B 1 208 ? -63.321 -25.996 -21.130 1.00 78.82  ?  208 ASN B CB  1 
ATOM   5288 C  CG  . ASN B 1 208 ? -61.974 -25.779 -20.484 1.00 81.82  ?  208 ASN B CG  1 
ATOM   5289 O  OD1 . ASN B 1 208 ? -60.959 -25.732 -21.176 1.00 85.35  ?  208 ASN B OD1 1 
ATOM   5290 N  ND2 . ASN B 1 208 ? -61.960 -25.652 -19.167 1.00 85.69  ?  208 ASN B ND2 1 
ATOM   5291 N  N   . THR B 1 209 ? -65.523 -28.558 -21.829 1.00 69.50  ?  209 THR B N   1 
ATOM   5292 C  CA  . THR B 1 209 ? -66.958 -28.816 -22.129 1.00 70.53  ?  209 THR B CA  1 
ATOM   5293 C  C   . THR B 1 209 ? -67.805 -27.727 -21.458 1.00 68.23  ?  209 THR B C   1 
ATOM   5294 O  O   . THR B 1 209 ? -68.739 -27.234 -22.108 1.00 69.30  ?  209 THR B O   1 
ATOM   5295 C  CB  . THR B 1 209 ? -67.385 -30.233 -21.725 1.00 72.26  ?  209 THR B CB  1 
ATOM   5296 O  OG1 . THR B 1 209 ? -67.237 -30.367 -20.312 1.00 78.58  ?  209 THR B OG1 1 
ATOM   5297 C  CG2 . THR B 1 209 ? -66.584 -31.307 -22.427 1.00 73.09  ?  209 THR B CG2 1 
ATOM   5298 N  N   . LEU B 1 210 ? -67.445 -27.331 -20.234 1.00 67.35  ?  210 LEU B N   1 
ATOM   5299 C  CA  . LEU B 1 210 ? -68.247 -26.433 -19.359 1.00 68.76  ?  210 LEU B CA  1 
ATOM   5300 C  C   . LEU B 1 210 ? -67.499 -25.114 -19.123 1.00 66.84  ?  210 LEU B C   1 
ATOM   5301 O  O   . LEU B 1 210 ? -66.272 -25.162 -18.938 1.00 74.51  ?  210 LEU B O   1 
ATOM   5302 C  CB  . LEU B 1 210 ? -68.497 -27.167 -18.039 1.00 70.75  ?  210 LEU B CB  1 
ATOM   5303 C  CG  . LEU B 1 210 ? -69.824 -26.858 -17.353 1.00 73.58  ?  210 LEU B CG  1 
ATOM   5304 C  CD1 . LEU B 1 210 ? -70.988 -27.403 -18.162 1.00 75.46  ?  210 LEU B CD1 1 
ATOM   5305 C  CD2 . LEU B 1 210 ? -69.844 -27.434 -15.949 1.00 75.53  ?  210 LEU B CD2 1 
ATOM   5306 N  N   . ARG B 1 211 ? -68.218 -23.986 -19.103 1.00 65.38  ?  211 ARG B N   1 
ATOM   5307 C  CA  A ARG B 1 211 ? -67.637 -22.630 -18.893 0.60 65.88  ?  211 ARG B CA  1 
ATOM   5308 C  CA  B ARG B 1 211 ? -67.617 -22.646 -18.845 0.40 65.43  ?  211 ARG B CA  1 
ATOM   5309 C  C   . ARG B 1 211 ? -68.644 -21.776 -18.106 1.00 67.04  ?  211 ARG B C   1 
ATOM   5310 O  O   . ARG B 1 211 ? -69.784 -21.639 -18.591 1.00 64.80  ?  211 ARG B O   1 
ATOM   5311 C  CB  A ARG B 1 211 ? -67.256 -22.038 -20.256 0.60 64.55  ?  211 ARG B CB  1 
ATOM   5312 C  CB  B ARG B 1 211 ? -67.099 -22.001 -20.137 0.40 63.48  ?  211 ARG B CB  1 
ATOM   5313 C  CG  A ARG B 1 211 ? -67.088 -20.525 -20.286 0.60 66.38  ?  211 ARG B CG  1 
ATOM   5314 C  CG  B ARG B 1 211 ? -68.175 -21.475 -21.072 0.40 63.76  ?  211 ARG B CG  1 
ATOM   5315 C  CD  A ARG B 1 211 ? -66.071 -20.024 -19.284 0.60 66.25  ?  211 ARG B CD  1 
ATOM   5316 C  CD  B ARG B 1 211 ? -67.754 -21.633 -22.519 0.40 62.49  ?  211 ARG B CD  1 
ATOM   5317 N  NE  A ARG B 1 211 ? -65.613 -18.677 -19.585 0.60 65.40  ?  211 ARG B NE  1 
ATOM   5318 N  NE  B ARG B 1 211 ? -67.093 -22.918 -22.695 0.40 60.91  ?  211 ARG B NE  1 
ATOM   5319 C  CZ  A ARG B 1 211 ? -64.656 -18.046 -18.916 0.60 64.86  ?  211 ARG B CZ  1 
ATOM   5320 C  CZ  B ARG B 1 211 ? -67.672 -24.003 -23.192 0.40 58.04  ?  211 ARG B CZ  1 
ATOM   5321 N  NH1 A ARG B 1 211 ? -64.050 -18.635 -17.898 0.60 63.75  ?  211 ARG B NH1 1 
ATOM   5322 N  NH1 B ARG B 1 211 ? -68.927 -23.966 -23.601 0.40 55.81  ?  211 ARG B NH1 1 
ATOM   5323 N  NH2 A ARG B 1 211 ? -64.299 -16.827 -19.270 0.60 64.06  ?  211 ARG B NH2 1 
ATOM   5324 N  NH2 B ARG B 1 211 ? -66.986 -25.124 -23.289 0.40 57.79  ?  211 ARG B NH2 1 
ATOM   5325 N  N   . ILE B 1 212 ? -68.228 -21.238 -16.954 1.00 70.04  ?  212 ILE B N   1 
ATOM   5326 C  CA  . ILE B 1 212 ? -69.070 -20.442 -16.012 1.00 70.19  ?  212 ILE B CA  1 
ATOM   5327 C  C   . ILE B 1 212 ? -68.613 -18.980 -16.022 1.00 69.70  ?  212 ILE B C   1 
ATOM   5328 O  O   . ILE B 1 212 ? -67.394 -18.736 -16.034 1.00 71.82  ?  212 ILE B O   1 
ATOM   5329 C  CB  . ILE B 1 212 ? -68.985 -21.037 -14.594 1.00 73.93  ?  212 ILE B CB  1 
ATOM   5330 C  CG1 . ILE B 1 212 ? -69.693 -22.391 -14.505 1.00 77.96  ?  212 ILE B CG1 1 
ATOM   5331 C  CG2 . ILE B 1 212 ? -69.504 -20.054 -13.552 1.00 75.46  ?  212 ILE B CG2 1 
ATOM   5332 C  CD1 . ILE B 1 212 ? -71.207 -22.311 -14.508 1.00 81.11  ?  212 ILE B CD1 1 
ATOM   5333 N  N   . ILE B 1 213 ? -69.577 -18.057 -16.011 1.00 67.10  ?  213 ILE B N   1 
ATOM   5334 C  CA  . ILE B 1 213 ? -69.393 -16.623 -15.643 1.00 63.98  ?  213 ILE B CA  1 
ATOM   5335 C  C   . ILE B 1 213 ? -70.363 -16.338 -14.493 1.00 64.60  ?  213 ILE B C   1 
ATOM   5336 O  O   . ILE B 1 213 ? -71.552 -16.146 -14.771 1.00 67.27  ?  213 ILE B O   1 
ATOM   5337 C  CB  . ILE B 1 213 ? -69.612 -15.700 -16.858 1.00 62.39  ?  213 ILE B CB  1 
ATOM   5338 C  CG1 . ILE B 1 213 ? -68.610 -16.010 -17.974 1.00 62.28  ?  213 ILE B CG1 1 
ATOM   5339 C  CG2 . ILE B 1 213 ? -69.565 -14.235 -16.445 1.00 63.31  ?  213 ILE B CG2 1 
ATOM   5340 C  CD1 . ILE B 1 213 ? -68.791 -15.185 -19.230 1.00 61.61  ?  213 ILE B CD1 1 
ATOM   5341 N  N   . SER B 1 214 ? -69.863 -16.348 -13.253 1.00 67.02  ?  214 SER B N   1 
ATOM   5342 C  CA  . SER B 1 214 ? -70.661 -16.210 -12.000 1.00 69.92  ?  214 SER B CA  1 
ATOM   5343 C  C   . SER B 1 214 ? -71.307 -14.818 -11.910 1.00 70.27  ?  214 SER B C   1 
ATOM   5344 O  O   . SER B 1 214 ? -72.482 -14.739 -11.506 1.00 74.19  ?  214 SER B O   1 
ATOM   5345 C  CB  . SER B 1 214 ? -69.802 -16.486 -10.792 1.00 73.37  ?  214 SER B CB  1 
ATOM   5346 O  OG  . SER B 1 214 ? -68.620 -15.693 -10.814 1.00 77.89  ?  214 SER B OG  1 
ATOM   5347 N  N   . ASP B 1 215 ? -70.565 -13.762 -12.255 1.00 68.42  ?  215 ASP B N   1 
ATOM   5348 C  CA  . ASP B 1 215 ? -71.021 -12.348 -12.157 1.00 67.64  ?  215 ASP B CA  1 
ATOM   5349 C  C   . ASP B 1 215 ? -70.270 -11.511 -13.198 1.00 67.61  ?  215 ASP B C   1 
ATOM   5350 O  O   . ASP B 1 215 ? -69.049 -11.317 -13.042 1.00 69.21  ?  215 ASP B O   1 
ATOM   5351 C  CB  . ASP B 1 215 ? -70.829 -11.819 -10.732 1.00 69.51  ?  215 ASP B CB  1 
ATOM   5352 C  CG  . ASP B 1 215 ? -71.385 -10.425 -10.484 1.00 71.29  ?  215 ASP B CG  1 
ATOM   5353 O  OD1 . ASP B 1 215 ? -71.801 -9.764  -11.457 1.00 69.82  ?  215 ASP B OD1 1 
ATOM   5354 O  OD2 . ASP B 1 215 ? -71.391 -10.009 -9.310  1.00 75.62  ?  215 ASP B OD2 1 
ATOM   5355 N  N   . ALA B 1 216 ? -70.986 -11.026 -14.214 1.00 68.74  ?  216 ALA B N   1 
ATOM   5356 C  CA  . ALA B 1 216 ? -70.446 -10.220 -15.335 1.00 69.86  ?  216 ALA B CA  1 
ATOM   5357 C  C   . ALA B 1 216 ? -69.981 -8.856  -14.812 1.00 71.96  ?  216 ALA B C   1 
ATOM   5358 O  O   . ALA B 1 216 ? -69.112 -8.238  -15.461 1.00 70.42  ?  216 ALA B O   1 
ATOM   5359 C  CB  . ALA B 1 216 ? -71.485 -10.068 -16.418 1.00 69.25  ?  216 ALA B CB  1 
ATOM   5360 N  N   . SER B 1 217 ? -70.551 -8.417  -13.685 1.00 76.45  ?  217 SER B N   1 
ATOM   5361 C  CA  . SER B 1 217 ? -70.243 -7.125  -13.011 1.00 80.76  ?  217 SER B CA  1 
ATOM   5362 C  C   . SER B 1 217 ? -69.478 -7.365  -11.701 1.00 82.58  ?  217 SER B C   1 
ATOM   5363 O  O   . SER B 1 217 ? -69.402 -6.430  -10.883 1.00 85.81  ?  217 SER B O   1 
ATOM   5364 C  CB  . SER B 1 217 ? -71.502 -6.335  -12.779 1.00 83.18  ?  217 SER B CB  1 
ATOM   5365 O  OG  . SER B 1 217 ? -72.173 -6.095  -14.006 1.00 84.90  ?  217 SER B OG  1 
ATOM   5366 N  N   . GLY B 1 218 ? -68.938 -8.571  -11.509 1.00 83.82  ?  218 GLY B N   1 
ATOM   5367 C  CA  . GLY B 1 218 ? -67.983 -8.873  -10.425 1.00 84.50  ?  218 GLY B CA  1 
ATOM   5368 C  C   . GLY B 1 218 ? -66.618 -8.292  -10.749 1.00 85.77  ?  218 GLY B C   1 
ATOM   5369 O  O   . GLY B 1 218 ? -66.271 -8.241  -11.948 1.00 88.13  ?  218 GLY B O   1 
ATOM   5370 N  N   . THR B 1 219 ? -65.877 -7.839  -9.732  1.00 84.25  ?  219 THR B N   1 
ATOM   5371 C  CA  . THR B 1 219 ? -64.486 -7.324  -9.886  1.00 81.13  ?  219 THR B CA  1 
ATOM   5372 C  C   . THR B 1 219 ? -63.537 -8.517  -10.007 1.00 75.31  ?  219 THR B C   1 
ATOM   5373 O  O   . THR B 1 219 ? -63.557 -9.410  -9.161  1.00 67.97  ?  219 THR B O   1 
ATOM   5374 C  CB  . THR B 1 219 ? -64.112 -6.372  -8.742  1.00 81.73  ?  219 THR B CB  1 
ATOM   5375 O  OG1 . THR B 1 219 ? -64.228 -7.080  -7.506  1.00 82.58  ?  219 THR B OG1 1 
ATOM   5376 C  CG2 . THR B 1 219 ? -64.979 -5.131  -8.709  1.00 80.53  ?  219 THR B CG2 1 
ATOM   5377 N  N   . PRO B 1 220 ? -62.685 -8.582  -11.059 1.00 73.27  ?  220 PRO B N   1 
ATOM   5378 C  CA  . PRO B 1 220 ? -61.748 -9.694  -11.220 1.00 73.48  ?  220 PRO B CA  1 
ATOM   5379 C  C   . PRO B 1 220 ? -60.666 -9.710  -10.128 1.00 74.12  ?  220 PRO B C   1 
ATOM   5380 O  O   . PRO B 1 220 ? -60.274 -8.649  -9.680  1.00 76.78  ?  220 PRO B O   1 
ATOM   5381 C  CB  . PRO B 1 220 ? -61.103 -9.468  -12.600 1.00 73.02  ?  220 PRO B CB  1 
ATOM   5382 C  CG  . PRO B 1 220 ? -61.963 -8.414  -13.277 1.00 73.79  ?  220 PRO B CG  1 
ATOM   5383 C  CD  . PRO B 1 220 ? -62.576 -7.605  -12.154 1.00 73.43  ?  220 PRO B CD  1 
ATOM   5384 N  N   . ILE B 1 221 ? -60.225 -10.910 -9.735  1.00 74.69  ?  221 ILE B N   1 
ATOM   5385 C  CA  . ILE B 1 221 ? -59.148 -11.151 -8.727  1.00 74.01  ?  221 ILE B CA  1 
ATOM   5386 C  C   . ILE B 1 221 ? -57.837 -11.413 -9.463  1.00 77.04  ?  221 ILE B C   1 
ATOM   5387 O  O   . ILE B 1 221 ? -57.758 -12.352 -10.251 1.00 75.17  ?  221 ILE B O   1 
ATOM   5388 C  CB  . ILE B 1 221 ? -59.510 -12.339 -7.814  1.00 72.32  ?  221 ILE B CB  1 
ATOM   5389 C  CG1 . ILE B 1 221 ? -60.914 -12.207 -7.215  1.00 72.74  ?  221 ILE B CG1 1 
ATOM   5390 C  CG2 . ILE B 1 221 ? -58.448 -12.534 -6.745  1.00 70.88  ?  221 ILE B CG2 1 
ATOM   5391 C  CD1 . ILE B 1 221 ? -61.190 -10.879 -6.550  1.00 75.10  ?  221 ILE B CD1 1 
ATOM   5392 N  N   . PRO B 1 222 ? -56.772 -10.607 -9.233  1.00 80.38  ?  222 PRO B N   1 
ATOM   5393 C  CA  . PRO B 1 222 ? -55.494 -10.817 -9.912  1.00 78.67  ?  222 PRO B CA  1 
ATOM   5394 C  C   . PRO B 1 222 ? -54.758 -12.058 -9.387  1.00 76.93  ?  222 PRO B C   1 
ATOM   5395 O  O   . PRO B 1 222 ? -54.879 -12.370 -8.212  1.00 73.17  ?  222 PRO B O   1 
ATOM   5396 C  CB  . PRO B 1 222 ? -54.697 -9.542  -9.605  1.00 79.53  ?  222 PRO B CB  1 
ATOM   5397 C  CG  . PRO B 1 222 ? -55.265 -9.065  -8.286  1.00 81.77  ?  222 PRO B CG  1 
ATOM   5398 C  CD  . PRO B 1 222 ? -56.729 -9.457  -8.315  1.00 82.44  ?  222 PRO B CD  1 
ATOM   5399 N  N   . VAL B 1 223 ? -54.044 -12.738 -10.285 1.00 76.31  ?  223 VAL B N   1 
ATOM   5400 C  CA  . VAL B 1 223 ? -53.127 -13.870 -9.967  1.00 78.86  ?  223 VAL B CA  1 
ATOM   5401 C  C   . VAL B 1 223 ? -51.726 -13.283 -9.775  1.00 76.05  ?  223 VAL B C   1 
ATOM   5402 O  O   . VAL B 1 223 ? -51.215 -12.665 -10.728 1.00 77.93  ?  223 VAL B O   1 
ATOM   5403 C  CB  . VAL B 1 223 ? -53.154 -14.938 -11.078 1.00 82.58  ?  223 VAL B CB  1 
ATOM   5404 C  CG1 . VAL B 1 223 ? -52.127 -16.036 -10.840 1.00 85.06  ?  223 VAL B CG1 1 
ATOM   5405 C  CG2 . VAL B 1 223 ? -54.544 -15.531 -11.249 1.00 83.18  ?  223 VAL B CG2 1 
ATOM   5406 N  N   . LEU B 1 224 ? -51.143 -13.464 -8.588  1.00 73.88  ?  224 LEU B N   1 
ATOM   5407 C  CA  . LEU B 1 224 ? -49.833 -12.873 -8.200  1.00 75.12  ?  224 LEU B CA  1 
ATOM   5408 C  C   . LEU B 1 224 ? -48.776 -13.975 -8.159  1.00 74.59  ?  224 LEU B C   1 
ATOM   5409 O  O   . LEU B 1 224 ? -48.939 -14.955 -7.434  1.00 78.83  ?  224 LEU B O   1 
ATOM   5410 C  CB  . LEU B 1 224 ? -49.986 -12.185 -6.839  1.00 75.39  ?  224 LEU B CB  1 
ATOM   5411 C  CG  . LEU B 1 224 ? -51.158 -11.208 -6.725  1.00 76.19  ?  224 LEU B CG  1 
ATOM   5412 C  CD1 . LEU B 1 224 ? -51.392 -10.804 -5.277  1.00 77.36  ?  224 LEU B CD1 1 
ATOM   5413 C  CD2 . LEU B 1 224 ? -50.941 -9.981  -7.602  1.00 74.21  ?  224 LEU B CD2 1 
ATOM   5414 N  N   . PRO B 1 225 ? -47.664 -13.871 -8.926  1.00 72.75  ?  225 PRO B N   1 
ATOM   5415 C  CA  . PRO B 1 225 ? -47.449 -12.781 -9.879  1.00 73.87  ?  225 PRO B CA  1 
ATOM   5416 C  C   . PRO B 1 225 ? -48.093 -13.046 -11.250 1.00 74.95  ?  225 PRO B C   1 
ATOM   5417 O  O   . PRO B 1 225 ? -48.153 -14.191 -11.661 1.00 71.27  ?  225 PRO B O   1 
ATOM   5418 C  CB  . PRO B 1 225 ? -45.919 -12.762 -9.989  1.00 73.74  ?  225 PRO B CB  1 
ATOM   5419 C  CG  . PRO B 1 225 ? -45.535 -14.223 -9.877  1.00 73.15  ?  225 PRO B CG  1 
ATOM   5420 C  CD  . PRO B 1 225 ? -46.538 -14.818 -8.908  1.00 72.63  ?  225 PRO B CD  1 
ATOM   5421 N  N   . ALA B 1 226 ? -48.563 -11.986 -11.916 1.00 78.70  ?  226 ALA B N   1 
ATOM   5422 C  CA  . ALA B 1 226 ? -49.155 -12.034 -13.276 1.00 82.09  ?  226 ALA B CA  1 
ATOM   5423 C  C   . ALA B 1 226 ? -48.142 -12.647 -14.250 1.00 82.12  ?  226 ALA B C   1 
ATOM   5424 O  O   . ALA B 1 226 ? -48.550 -13.445 -15.118 1.00 78.38  ?  226 ALA B O   1 
ATOM   5425 C  CB  . ALA B 1 226 ? -49.569 -10.650 -13.713 1.00 83.83  ?  226 ALA B CB  1 
ATOM   5426 N  N   . VAL B 1 227 ? -46.869 -12.279 -14.093 1.00 86.30  ?  227 VAL B N   1 
ATOM   5427 C  CA  . VAL B 1 227 ? -45.716 -12.818 -14.873 1.00 87.86  ?  227 VAL B CA  1 
ATOM   5428 C  C   . VAL B 1 227 ? -44.609 -13.193 -13.877 1.00 85.77  ?  227 VAL B C   1 
ATOM   5429 O  O   . VAL B 1 227 ? -44.292 -12.361 -13.005 1.00 85.13  ?  227 VAL B O   1 
ATOM   5430 C  CB  . VAL B 1 227 ? -45.252 -11.806 -15.940 1.00 92.20  ?  227 VAL B CB  1 
ATOM   5431 C  CG1 . VAL B 1 227 ? -44.716 -10.515 -15.334 1.00 93.27  ?  227 VAL B CG1 1 
ATOM   5432 C  CG2 . VAL B 1 227 ? -44.241 -12.415 -16.898 1.00 93.07  ?  227 VAL B CG2 1 
ATOM   5433 N  N   . ASP B 1 228 ? -44.073 -14.414 -13.979 1.00 86.26  ?  228 ASP B N   1 
ATOM   5434 C  CA  . ASP B 1 228 ? -43.110 -14.984 -12.996 1.00 89.55  ?  228 ASP B CA  1 
ATOM   5435 C  C   . ASP B 1 228 ? -41.676 -14.736 -13.487 1.00 96.14  ?  228 ASP B C   1 
ATOM   5436 O  O   . ASP B 1 228 ? -41.501 -13.937 -14.432 1.00 96.51  ?  228 ASP B O   1 
ATOM   5437 C  CB  . ASP B 1 228 ? -43.418 -16.459 -12.715 1.00 87.26  ?  228 ASP B CB  1 
ATOM   5438 C  CG  . ASP B 1 228 ? -43.025 -17.430 -13.816 1.00 84.95  ?  228 ASP B CG  1 
ATOM   5439 O  OD1 . ASP B 1 228 ? -42.585 -16.965 -14.884 1.00 80.90  ?  228 ASP B OD1 1 
ATOM   5440 O  OD2 . ASP B 1 228 ? -43.169 -18.651 -13.592 1.00 81.00  ?  228 ASP B OD2 1 
ATOM   5441 N  N   . VAL B 1 229 ? -40.698 -15.392 -12.851 1.00 104.58 ?  229 VAL B N   1 
ATOM   5442 C  CA  . VAL B 1 229 ? -39.232 -15.236 -13.111 1.00 108.21 ?  229 VAL B CA  1 
ATOM   5443 C  C   . VAL B 1 229 ? -38.942 -15.459 -14.602 1.00 107.48 ?  229 VAL B C   1 
ATOM   5444 O  O   . VAL B 1 229 ? -38.154 -14.675 -15.172 1.00 105.88 ?  229 VAL B O   1 
ATOM   5445 C  CB  . VAL B 1 229 ? -38.388 -16.184 -12.232 1.00 110.93 ?  229 VAL B CB  1 
ATOM   5446 C  CG1 . VAL B 1 229 ? -38.514 -15.845 -10.753 1.00 111.91 ?  229 VAL B CG1 1 
ATOM   5447 C  CG2 . VAL B 1 229 ? -38.709 -17.654 -12.477 1.00 110.64 ?  229 VAL B CG2 1 
ATOM   5448 N  N   . SER B 1 230 ? -39.573 -16.473 -15.205 1.00 102.23 ?  230 SER B N   1 
ATOM   5449 C  CA  . SER B 1 230 ? -39.323 -16.921 -16.605 1.00 102.77 ?  230 SER B CA  1 
ATOM   5450 C  C   . SER B 1 230 ? -40.008 -15.998 -17.626 1.00 102.46 ?  230 SER B C   1 
ATOM   5451 O  O   . SER B 1 230 ? -39.909 -16.295 -18.836 1.00 105.08 ?  230 SER B O   1 
ATOM   5452 C  CB  . SER B 1 230 ? -39.750 -18.355 -16.802 1.00 104.38 ?  230 SER B CB  1 
ATOM   5453 O  OG  . SER B 1 230 ? -41.119 -18.537 -16.465 1.00 104.49 ?  230 SER B OG  1 
ATOM   5454 N  N   . GLY B 1 231 ? -40.679 -14.932 -17.172 1.00 99.61  ?  231 GLY B N   1 
ATOM   5455 C  CA  . GLY B 1 231 ? -41.347 -13.945 -18.044 1.00 98.56  ?  231 GLY B CA  1 
ATOM   5456 C  C   . GLY B 1 231 ? -42.566 -14.522 -18.750 1.00 98.06  ?  231 GLY B C   1 
ATOM   5457 O  O   . GLY B 1 231 ? -42.945 -13.969 -19.800 1.00 99.39  ?  231 GLY B O   1 
ATOM   5458 N  N   . GLU B 1 232 ? -43.168 -15.580 -18.190 1.00 96.89  ?  232 GLU B N   1 
ATOM   5459 C  CA  . GLU B 1 232 ? -44.343 -16.298 -18.760 1.00 92.35  ?  232 GLU B CA  1 
ATOM   5460 C  C   . GLU B 1 232 ? -45.595 -15.961 -17.954 1.00 88.06  ?  232 GLU B C   1 
ATOM   5461 O  O   . GLU B 1 232 ? -45.536 -15.844 -16.731 1.00 83.52  ?  232 GLU B O   1 
ATOM   5462 C  CB  . GLU B 1 232 ? -44.112 -17.811 -18.748 1.00 92.78  ?  232 GLU B CB  1 
ATOM   5463 C  CG  . GLU B 1 232 ? -43.070 -18.280 -19.747 1.00 98.51  ?  232 GLU B CG  1 
ATOM   5464 C  CD  . GLU B 1 232 ? -43.510 -18.259 -21.202 1.00 102.85 ?  232 GLU B CD  1 
ATOM   5465 O  OE1 . GLU B 1 232 ? -43.680 -19.352 -21.780 1.00 107.51 ?  232 GLU B OE1 1 
ATOM   5466 O  OE2 . GLU B 1 232 ? -43.665 -17.153 -21.763 1.00 100.53 ?  232 GLU B OE2 1 
ATOM   5467 N  N   . PRO B 1 233 ? -46.767 -15.796 -18.612 1.00 82.63  ?  233 PRO B N   1 
ATOM   5468 C  CA  . PRO B 1 233 ? -48.040 -15.669 -17.906 1.00 78.96  ?  233 PRO B CA  1 
ATOM   5469 C  C   . PRO B 1 233 ? -48.618 -17.056 -17.592 1.00 73.93  ?  233 PRO B C   1 
ATOM   5470 O  O   . PRO B 1 233 ? -48.242 -18.003 -18.262 1.00 72.64  ?  233 PRO B O   1 
ATOM   5471 C  CB  . PRO B 1 233 ? -48.896 -14.902 -18.920 1.00 78.73  ?  233 PRO B CB  1 
ATOM   5472 C  CG  . PRO B 1 233 ? -48.414 -15.424 -20.259 1.00 80.50  ?  233 PRO B CG  1 
ATOM   5473 C  CD  . PRO B 1 233 ? -46.938 -15.721 -20.072 1.00 81.43  ?  233 PRO B CD  1 
ATOM   5474 N  N   . LEU B 1 234 ? -49.493 -17.142 -16.586 1.00 70.37  ?  234 LEU B N   1 
ATOM   5475 C  CA  . LEU B 1 234 ? -50.137 -18.415 -16.160 1.00 69.36  ?  234 LEU B CA  1 
ATOM   5476 C  C   . LEU B 1 234 ? -51.238 -18.779 -17.166 1.00 69.80  ?  234 LEU B C   1 
ATOM   5477 O  O   . LEU B 1 234 ? -52.197 -17.991 -17.313 1.00 65.25  ?  234 LEU B O   1 
ATOM   5478 C  CB  . LEU B 1 234 ? -50.697 -18.267 -14.742 1.00 66.70  ?  234 LEU B CB  1 
ATOM   5479 C  CG  . LEU B 1 234 ? -51.334 -19.523 -14.150 1.00 66.31  ?  234 LEU B CG  1 
ATOM   5480 C  CD1 . LEU B 1 234 ? -50.374 -20.702 -14.193 1.00 67.51  ?  234 LEU B CD1 1 
ATOM   5481 C  CD2 . LEU B 1 234 ? -51.802 -19.277 -12.725 1.00 64.78  ?  234 LEU B CD2 1 
ATOM   5482 N  N   . ASP B 1 235 ? -51.080 -19.917 -17.848 1.00 71.23  ?  235 ASP B N   1 
ATOM   5483 C  CA  . ASP B 1 235 ? -52.067 -20.457 -18.820 1.00 71.68  ?  235 ASP B CA  1 
ATOM   5484 C  C   . ASP B 1 235 ? -53.228 -21.060 -18.020 1.00 70.05  ?  235 ASP B C   1 
ATOM   5485 O  O   . ASP B 1 235 ? -53.016 -22.095 -17.355 1.00 69.98  ?  235 ASP B O   1 
ATOM   5486 C  CB  . ASP B 1 235 ? -51.416 -21.461 -19.776 1.00 72.29  ?  235 ASP B CB  1 
ATOM   5487 C  CG  . ASP B 1 235 ? -52.215 -21.723 -21.043 1.00 73.42  ?  235 ASP B CG  1 
ATOM   5488 O  OD1 . ASP B 1 235 ? -53.457 -21.750 -20.960 1.00 76.01  ?  235 ASP B OD1 1 
ATOM   5489 O  OD2 . ASP B 1 235 ? -51.587 -21.910 -22.104 1.00 72.65  ?  235 ASP B OD2 1 
ATOM   5490 N  N   . LEU B 1 236 ? -54.399 -20.416 -18.076 1.00 66.11  ?  236 LEU B N   1 
ATOM   5491 C  CA  . LEU B 1 236 ? -55.614 -20.800 -17.308 1.00 64.53  ?  236 LEU B CA  1 
ATOM   5492 C  C   . LEU B 1 236 ? -56.622 -21.492 -18.234 1.00 64.60  ?  236 LEU B C   1 
ATOM   5493 O  O   . LEU B 1 236 ? -57.824 -21.471 -17.911 1.00 65.06  ?  236 LEU B O   1 
ATOM   5494 C  CB  . LEU B 1 236 ? -56.206 -19.537 -16.677 1.00 62.25  ?  236 LEU B CB  1 
ATOM   5495 C  CG  . LEU B 1 236 ? -55.380 -18.928 -15.546 1.00 61.12  ?  236 LEU B CG  1 
ATOM   5496 C  CD1 . LEU B 1 236 ? -55.812 -17.496 -15.269 1.00 61.25  ?  236 LEU B CD1 1 
ATOM   5497 C  CD2 . LEU B 1 236 ? -55.482 -19.776 -14.286 1.00 59.90  ?  236 LEU B CD2 1 
ATOM   5498 N  N   . SER B 1 237 ? -56.142 -22.119 -19.315 1.00 64.15  ?  237 SER B N   1 
ATOM   5499 C  CA  . SER B 1 237 ? -56.988 -22.762 -20.360 1.00 61.47  ?  237 SER B CA  1 
ATOM   5500 C  C   . SER B 1 237 ? -57.986 -23.733 -19.717 1.00 60.26  ?  237 SER B C   1 
ATOM   5501 O  O   . SER B 1 237 ? -59.179 -23.651 -20.054 1.00 63.56  ?  237 SER B O   1 
ATOM   5502 C  CB  . SER B 1 237 ? -56.145 -23.448 -21.403 1.00 62.02  ?  237 SER B CB  1 
ATOM   5503 O  OG  . SER B 1 237 ? -55.632 -22.507 -22.337 1.00 60.75  ?  237 SER B OG  1 
ATOM   5504 N  N   . TYR B 1 238 ? -57.521 -24.593 -18.808 1.00 58.49  ?  238 TYR B N   1 
ATOM   5505 C  CA  . TYR B 1 238 ? -58.334 -25.665 -18.174 1.00 60.63  ?  238 TYR B CA  1 
ATOM   5506 C  C   . TYR B 1 238 ? -58.789 -25.240 -16.773 1.00 58.81  ?  238 TYR B C   1 
ATOM   5507 O  O   . TYR B 1 238 ? -59.405 -26.058 -16.068 1.00 57.76  ?  238 TYR B O   1 
ATOM   5508 C  CB  . TYR B 1 238 ? -57.551 -26.979 -18.141 1.00 64.62  ?  238 TYR B CB  1 
ATOM   5509 C  CG  . TYR B 1 238 ? -57.136 -27.489 -19.498 1.00 67.60  ?  238 TYR B CG  1 
ATOM   5510 C  CD1 . TYR B 1 238 ? -55.930 -27.108 -20.061 1.00 70.58  ?  238 TYR B CD1 1 
ATOM   5511 C  CD2 . TYR B 1 238 ? -57.948 -28.347 -20.224 1.00 68.52  ?  238 TYR B CD2 1 
ATOM   5512 C  CE1 . TYR B 1 238 ? -55.536 -27.568 -21.307 1.00 73.33  ?  238 TYR B CE1 1 
ATOM   5513 C  CE2 . TYR B 1 238 ? -57.570 -28.815 -21.473 1.00 70.29  ?  238 TYR B CE2 1 
ATOM   5514 C  CZ  . TYR B 1 238 ? -56.359 -28.424 -22.017 1.00 73.33  ?  238 TYR B CZ  1 
ATOM   5515 O  OH  . TYR B 1 238 ? -55.965 -28.873 -23.244 1.00 77.43  ?  238 TYR B OH  1 
ATOM   5516 N  N   . ALA B 1 239 ? -58.505 -24.000 -16.377 1.00 61.60  ?  239 ALA B N   1 
ATOM   5517 C  CA  . ALA B 1 239 ? -59.000 -23.397 -15.116 1.00 63.30  ?  239 ALA B CA  1 
ATOM   5518 C  C   . ALA B 1 239 ? -60.448 -22.942 -15.327 1.00 61.77  ?  239 ALA B C   1 
ATOM   5519 O  O   . ALA B 1 239 ? -60.694 -22.164 -16.272 1.00 59.42  ?  239 ALA B O   1 
ATOM   5520 C  CB  . ALA B 1 239 ? -58.117 -22.248 -14.691 1.00 63.42  ?  239 ALA B CB  1 
ATOM   5521 N  N   . HIS B 1 240 ? -61.370 -23.412 -14.484 1.00 60.79  ?  240 HIS B N   1 
ATOM   5522 C  CA  . HIS B 1 240 ? -62.808 -23.041 -14.547 1.00 63.02  ?  240 HIS B CA  1 
ATOM   5523 C  C   . HIS B 1 240 ? -63.003 -21.623 -13.988 1.00 63.14  ?  240 HIS B C   1 
ATOM   5524 O  O   . HIS B 1 240 ? -63.967 -20.955 -14.411 1.00 62.28  ?  240 HIS B O   1 
ATOM   5525 C  CB  . HIS B 1 240 ? -63.680 -24.121 -13.892 1.00 63.00  ?  240 HIS B CB  1 
ATOM   5526 C  CG  . HIS B 1 240 ? -63.693 -24.122 -12.404 1.00 64.10  ?  240 HIS B CG  1 
ATOM   5527 N  ND1 . HIS B 1 240 ? -64.410 -23.196 -11.671 1.00 67.28  ?  240 HIS B ND1 1 
ATOM   5528 C  CD2 . HIS B 1 240 ? -63.136 -24.970 -11.513 1.00 64.97  ?  240 HIS B CD2 1 
ATOM   5529 C  CE1 . HIS B 1 240 ? -64.267 -23.455 -10.386 1.00 69.83  ?  240 HIS B CE1 1 
ATOM   5530 N  NE2 . HIS B 1 240 ? -63.489 -24.542 -10.261 1.00 67.43  ?  240 HIS B NE2 1 
ATOM   5531 N  N   . LEU B 1 241 ? -62.101 -21.165 -13.113 1.00 63.83  ?  241 LEU B N   1 
ATOM   5532 C  CA  . LEU B 1 241 ? -62.159 -19.808 -12.499 1.00 62.06  ?  241 LEU B CA  1 
ATOM   5533 C  C   . LEU B 1 241 ? -61.555 -18.764 -13.448 1.00 61.36  ?  241 LEU B C   1 
ATOM   5534 O  O   . LEU B 1 241 ? -61.673 -17.560 -13.138 1.00 56.76  ?  241 LEU B O   1 
ATOM   5535 C  CB  . LEU B 1 241 ? -61.426 -19.829 -11.155 1.00 62.00  ?  241 LEU B CB  1 
ATOM   5536 C  CG  . LEU B 1 241 ? -62.128 -20.618 -10.050 1.00 63.23  ?  241 LEU B CG  1 
ATOM   5537 C  CD1 . LEU B 1 241 ? -61.156 -20.992 -8.942  1.00 64.09  ?  241 LEU B CD1 1 
ATOM   5538 C  CD2 . LEU B 1 241 ? -63.303 -19.833 -9.488  1.00 62.86  ?  241 LEU B CD2 1 
ATOM   5539 N  N   . ARG B 1 242 ? -60.946 -19.196 -14.561 1.00 61.46  ?  242 ARG B N   1 
ATOM   5540 C  CA  . ARG B 1 242 ? -60.389 -18.275 -15.595 1.00 62.24  ?  242 ARG B CA  1 
ATOM   5541 C  C   . ARG B 1 242 ? -61.364 -17.108 -15.803 1.00 61.83  ?  242 ARG B C   1 
ATOM   5542 O  O   . ARG B 1 242 ? -62.546 -17.372 -16.057 1.00 65.15  ?  242 ARG B O   1 
ATOM   5543 C  CB  . ARG B 1 242 ? -60.134 -19.029 -16.904 1.00 62.44  ?  242 ARG B CB  1 
ATOM   5544 C  CG  . ARG B 1 242 ? -59.555 -18.177 -18.026 1.00 64.47  ?  242 ARG B CG  1 
ATOM   5545 C  CD  . ARG B 1 242 ? -59.435 -18.951 -19.326 1.00 68.32  ?  242 ARG B CD  1 
ATOM   5546 N  NE  . ARG B 1 242 ? -60.737 -19.321 -19.874 1.00 70.76  ?  242 ARG B NE  1 
ATOM   5547 C  CZ  . ARG B 1 242 ? -61.443 -18.594 -20.740 1.00 73.77  ?  242 ARG B CZ  1 
ATOM   5548 N  NH1 . ARG B 1 242 ? -60.983 -17.435 -21.185 1.00 75.73  ?  242 ARG B NH1 1 
ATOM   5549 N  NH2 . ARG B 1 242 ? -62.615 -19.032 -21.166 1.00 75.03  ?  242 ARG B NH2 1 
ATOM   5550 N  N   . ASN B 1 243 ? -60.890 -15.867 -15.683 1.00 65.81  ?  243 ASN B N   1 
ATOM   5551 C  CA  . ASN B 1 243 ? -61.716 -14.650 -15.910 1.00 69.22  ?  243 ASN B CA  1 
ATOM   5552 C  C   . ASN B 1 243 ? -61.991 -14.521 -17.412 1.00 68.37  ?  243 ASN B C   1 
ATOM   5553 O  O   . ASN B 1 243 ? -61.207 -15.061 -18.211 1.00 65.96  ?  243 ASN B O   1 
ATOM   5554 C  CB  . ASN B 1 243 ? -61.066 -13.384 -15.344 1.00 72.57  ?  243 ASN B CB  1 
ATOM   5555 C  CG  . ASN B 1 243 ? -62.012 -12.202 -15.306 1.00 73.53  ?  243 ASN B CG  1 
ATOM   5556 O  OD1 . ASN B 1 243 ? -62.983 -12.202 -14.551 1.00 76.11  ?  243 ASN B OD1 1 
ATOM   5557 N  ND2 . ASN B 1 243 ? -61.746 -11.193 -16.121 1.00 73.07  ?  243 ASN B ND2 1 
ATOM   5558 N  N   . PHE B 1 244 ? -63.065 -13.809 -17.756 1.00 70.91  ?  244 PHE B N   1 
ATOM   5559 C  CA  . PHE B 1 244 ? -63.642 -13.697 -19.123 1.00 71.44  ?  244 PHE B CA  1 
ATOM   5560 C  C   . PHE B 1 244 ? -63.205 -12.375 -19.751 1.00 68.56  ?  244 PHE B C   1 
ATOM   5561 O  O   . PHE B 1 244 ? -62.936 -11.420 -19.007 1.00 67.26  ?  244 PHE B O   1 
ATOM   5562 C  CB  . PHE B 1 244 ? -65.171 -13.801 -19.077 1.00 74.75  ?  244 PHE B CB  1 
ATOM   5563 C  CG  . PHE B 1 244 ? -65.854 -12.844 -18.130 1.00 75.98  ?  244 PHE B CG  1 
ATOM   5564 C  CD1 . PHE B 1 244 ? -65.936 -13.133 -16.774 1.00 76.48  ?  244 PHE B CD1 1 
ATOM   5565 C  CD2 . PHE B 1 244 ? -66.427 -11.666 -18.592 1.00 73.61  ?  244 PHE B CD2 1 
ATOM   5566 C  CE1 . PHE B 1 244 ? -66.555 -12.256 -15.898 1.00 77.92  ?  244 PHE B CE1 1 
ATOM   5567 C  CE2 . PHE B 1 244 ? -67.055 -10.797 -17.715 1.00 73.82  ?  244 PHE B CE2 1 
ATOM   5568 C  CZ  . PHE B 1 244 ? -67.113 -11.091 -16.370 1.00 78.27  ?  244 PHE B CZ  1 
ATOM   5569 N  N   . SER B 1 245 ? -63.140 -12.337 -21.083 1.00 70.82  ?  245 SER B N   1 
ATOM   5570 C  CA  . SER B 1 245 ? -62.818 -11.112 -21.867 1.00 72.48  ?  245 SER B CA  1 
ATOM   5571 C  C   . SER B 1 245 ? -63.682 -9.948  -21.390 1.00 73.02  ?  245 SER B C   1 
ATOM   5572 O  O   . SER B 1 245 ? -64.880 -10.117 -21.184 1.00 76.47  ?  245 SER B O   1 
ATOM   5573 C  CB  . SER B 1 245 ? -62.993 -11.328 -23.345 1.00 72.51  ?  245 SER B CB  1 
ATOM   5574 O  OG  . SER B 1 245 ? -62.736 -10.129 -24.062 1.00 72.16  ?  245 SER B OG  1 
ATOM   5575 N  N   . PRO B 1 246 ? -63.110 -8.736  -21.199 1.00 77.07  ?  246 PRO B N   1 
ATOM   5576 C  CA  . PRO B 1 246 ? -63.919 -7.551  -20.911 1.00 78.13  ?  246 PRO B CA  1 
ATOM   5577 C  C   . PRO B 1 246 ? -64.780 -7.123  -22.113 1.00 77.60  ?  246 PRO B C   1 
ATOM   5578 O  O   . PRO B 1 246 ? -65.680 -6.327  -21.920 1.00 82.13  ?  246 PRO B O   1 
ATOM   5579 C  CB  . PRO B 1 246 ? -62.882 -6.476  -20.541 1.00 78.44  ?  246 PRO B CB  1 
ATOM   5580 C  CG  . PRO B 1 246 ? -61.603 -6.926  -21.217 1.00 77.19  ?  246 PRO B CG  1 
ATOM   5581 C  CD  . PRO B 1 246 ? -61.669 -8.439  -21.244 1.00 77.49  ?  246 PRO B CD  1 
ATOM   5582 N  N   . ILE B 1 247 ? -64.488 -7.645  -23.311 1.00 73.06  ?  247 ILE B N   1 
ATOM   5583 C  CA  . ILE B 1 247 ? -65.306 -7.419  -24.541 1.00 73.00  ?  247 ILE B CA  1 
ATOM   5584 C  C   . ILE B 1 247 ? -66.639 -8.152  -24.363 1.00 73.24  ?  247 ILE B C   1 
ATOM   5585 O  O   . ILE B 1 247 ? -67.694 -7.536  -24.605 1.00 73.57  ?  247 ILE B O   1 
ATOM   5586 C  CB  . ILE B 1 247 ? -64.561 -7.877  -25.813 1.00 73.79  ?  247 ILE B CB  1 
ATOM   5587 C  CG1 . ILE B 1 247 ? -63.261 -7.096  -26.032 1.00 75.74  ?  247 ILE B CG1 1 
ATOM   5588 C  CG2 . ILE B 1 247 ? -65.472 -7.804  -27.034 1.00 74.14  ?  247 ILE B CG2 1 
ATOM   5589 C  CD1 . ILE B 1 247 ? -63.454 -5.630  -26.365 1.00 77.61  ?  247 ILE B CD1 1 
ATOM   5590 N  N   . HIS B 1 248 ? -66.581 -9.419  -23.948 1.00 72.05  ?  248 HIS B N   1 
ATOM   5591 C  CA  . HIS B 1 248 ? -67.767 -10.280 -23.700 1.00 70.74  ?  248 HIS B CA  1 
ATOM   5592 C  C   . HIS B 1 248 ? -68.502 -9.798  -22.443 1.00 73.97  ?  248 HIS B C   1 
ATOM   5593 O  O   . HIS B 1 248 ? -69.740 -9.942  -22.408 1.00 73.50  ?  248 HIS B O   1 
ATOM   5594 C  CB  . HIS B 1 248 ? -67.352 -11.752 -23.614 1.00 70.24  ?  248 HIS B CB  1 
ATOM   5595 C  CG  . HIS B 1 248 ? -68.507 -12.686 -23.475 1.00 70.55  ?  248 HIS B CG  1 
ATOM   5596 N  ND1 . HIS B 1 248 ? -69.465 -12.822 -24.461 1.00 65.93  ?  248 HIS B ND1 1 
ATOM   5597 C  CD2 . HIS B 1 248 ? -68.864 -13.524 -22.477 1.00 68.94  ?  248 HIS B CD2 1 
ATOM   5598 C  CE1 . HIS B 1 248 ? -70.364 -13.702 -24.075 1.00 66.79  ?  248 HIS B CE1 1 
ATOM   5599 N  NE2 . HIS B 1 248 ? -70.015 -14.154 -22.862 1.00 67.89  ?  248 HIS B NE2 1 
ATOM   5600 N  N   . CYS B 1 249 ? -67.769 -9.257  -21.459 1.00 77.16  ?  249 CYS B N   1 
ATOM   5601 C  CA  . CYS B 1 249 ? -68.330 -8.604  -20.240 1.00 81.48  ?  249 CYS B CA  1 
ATOM   5602 C  C   . CYS B 1 249 ? -69.373 -7.562  -20.647 1.00 77.42  ?  249 CYS B C   1 
ATOM   5603 O  O   . CYS B 1 249 ? -70.536 -7.662  -20.198 1.00 71.52  ?  249 CYS B O   1 
ATOM   5604 C  CB  . CYS B 1 249 ? -67.250 -7.889  -19.431 1.00 89.73  ?  249 CYS B CB  1 
ATOM   5605 S  SG  . CYS B 1 249 ? -67.881 -6.968  -17.999 1.00 91.53  ?  249 CYS B SG  1 
ATOM   5606 N  N   . GLU B 1 250 ? -68.942 -6.597  -21.461 1.00 75.87  ?  250 GLU B N   1 
ATOM   5607 C  CA  . GLU B 1 250 ? -69.754 -5.435  -21.903 1.00 80.49  ?  250 GLU B CA  1 
ATOM   5608 C  C   . GLU B 1 250 ? -70.936 -5.944  -22.737 1.00 81.88  ?  250 GLU B C   1 
ATOM   5609 O  O   . GLU B 1 250 ? -72.025 -5.346  -22.630 1.00 87.24  ?  250 GLU B O   1 
ATOM   5610 C  CB  . GLU B 1 250 ? -68.874 -4.448  -22.674 1.00 82.60  ?  250 GLU B CB  1 
ATOM   5611 C  CG  . GLU B 1 250 ? -69.443 -3.044  -22.750 1.00 84.28  ?  250 GLU B CG  1 
ATOM   5612 C  CD  . GLU B 1 250 ? -68.579 -2.077  -23.541 1.00 85.74  ?  250 GLU B CD  1 
ATOM   5613 O  OE1 . GLU B 1 250 ? -67.363 -2.016  -23.264 1.00 85.95  ?  250 GLU B OE1 1 
ATOM   5614 O  OE2 . GLU B 1 250 ? -69.120 -1.399  -24.441 1.00 89.05  ?  250 GLU B OE2 1 
ATOM   5615 N  N   . TYR B 1 251 ? -70.736 -7.020  -23.509 1.00 78.40  ?  251 TYR B N   1 
ATOM   5616 C  CA  . TYR B 1 251 ? -71.790 -7.669  -24.336 1.00 72.50  ?  251 TYR B CA  1 
ATOM   5617 C  C   . TYR B 1 251 ? -72.894 -8.206  -23.413 1.00 70.14  ?  251 TYR B C   1 
ATOM   5618 O  O   . TYR B 1 251 ? -74.067 -7.845  -23.623 1.00 72.40  ?  251 TYR B O   1 
ATOM   5619 C  CB  . TYR B 1 251 ? -71.215 -8.769  -25.234 1.00 70.51  ?  251 TYR B CB  1 
ATOM   5620 C  CG  . TYR B 1 251 ? -72.027 -9.012  -26.482 1.00 69.23  ?  251 TYR B CG  1 
ATOM   5621 C  CD1 . TYR B 1 251 ? -73.308 -9.542  -26.414 1.00 69.50  ?  251 TYR B CD1 1 
ATOM   5622 C  CD2 . TYR B 1 251 ? -71.535 -8.682  -27.734 1.00 68.31  ?  251 TYR B CD2 1 
ATOM   5623 C  CE1 . TYR B 1 251 ? -74.073 -9.748  -27.551 1.00 68.07  ?  251 TYR B CE1 1 
ATOM   5624 C  CE2 . TYR B 1 251 ? -72.286 -8.881  -28.883 1.00 68.89  ?  251 TYR B CE2 1 
ATOM   5625 C  CZ  . TYR B 1 251 ? -73.561 -9.415  -28.792 1.00 67.91  ?  251 TYR B CZ  1 
ATOM   5626 O  OH  . TYR B 1 251 ? -74.308 -9.612  -29.917 1.00 63.40  ?  251 TYR B OH  1 
ATOM   5627 N  N   . LEU B 1 252 ? -72.530 -9.032  -22.425 1.00 67.05  ?  252 LEU B N   1 
ATOM   5628 C  CA  . LEU B 1 252 ? -73.488 -9.628  -21.451 1.00 67.40  ?  252 LEU B CA  1 
ATOM   5629 C  C   . LEU B 1 252 ? -74.180 -8.505  -20.676 1.00 67.63  ?  252 LEU B C   1 
ATOM   5630 O  O   . LEU B 1 252 ? -75.406 -8.589  -20.507 1.00 68.35  ?  252 LEU B O   1 
ATOM   5631 C  CB  . LEU B 1 252 ? -72.763 -10.576 -20.488 1.00 65.76  ?  252 LEU B CB  1 
ATOM   5632 C  CG  . LEU B 1 252 ? -72.247 -11.886 -21.083 1.00 64.43  ?  252 LEU B CG  1 
ATOM   5633 C  CD1 . LEU B 1 252 ? -71.702 -12.790 -19.989 1.00 63.47  ?  252 LEU B CD1 1 
ATOM   5634 C  CD2 . LEU B 1 252 ? -73.332 -12.607 -21.870 1.00 64.91  ?  252 LEU B CD2 1 
ATOM   5635 N  N   . ARG B 1 253 ? -73.414 -7.509  -20.218 1.00 71.15  ?  253 ARG B N   1 
ATOM   5636 C  CA  . ARG B 1 253 ? -73.940 -6.343  -19.452 1.00 70.71  ?  253 ARG B CA  1 
ATOM   5637 C  C   . ARG B 1 253 ? -75.017 -5.646  -20.295 1.00 69.78  ?  253 ARG B C   1 
ATOM   5638 O  O   . ARG B 1 253 ? -76.149 -5.480  -19.792 1.00 67.76  ?  253 ARG B O   1 
ATOM   5639 C  CB  . ARG B 1 253 ? -72.799 -5.393  -19.068 1.00 69.75  ?  253 ARG B CB  1 
ATOM   5640 N  N   . ASN B 1 254 ? -74.682 -5.302  -21.544 1.00 68.47  ?  254 ASN B N   1 
ATOM   5641 C  CA  . ASN B 1 254 ? -75.584 -4.628  -22.519 1.00 70.40  ?  254 ASN B CA  1 
ATOM   5642 C  C   . ASN B 1 254 ? -76.893 -5.414  -22.680 1.00 72.78  ?  254 ASN B C   1 
ATOM   5643 O  O   . ASN B 1 254 ? -77.930 -4.769  -22.928 1.00 79.72  ?  254 ASN B O   1 
ATOM   5644 C  CB  . ASN B 1 254 ? -74.904 -4.441  -23.879 1.00 71.91  ?  254 ASN B CB  1 
ATOM   5645 C  CG  . ASN B 1 254 ? -73.798 -3.405  -23.861 1.00 72.17  ?  254 ASN B CG  1 
ATOM   5646 O  OD1 . ASN B 1 254 ? -73.486 -2.833  -22.818 1.00 73.32  ?  254 ASN B OD1 1 
ATOM   5647 N  ND2 . ASN B 1 254 ? -73.196 -3.159  -25.012 1.00 72.58  ?  254 ASN B ND2 1 
ATOM   5648 N  N   . MET B 1 255 ? -76.844 -6.747  -22.560 1.00 73.12  ?  255 MET B N   1 
ATOM   5649 C  CA  . MET B 1 255 ? -78.008 -7.661  -22.750 1.00 70.92  ?  255 MET B CA  1 
ATOM   5650 C  C   . MET B 1 255 ? -78.842 -7.772  -21.467 1.00 68.06  ?  255 MET B C   1 
ATOM   5651 O  O   . MET B 1 255 ? -79.938 -8.360  -21.538 1.00 69.91  ?  255 MET B O   1 
ATOM   5652 C  CB  . MET B 1 255 ? -77.544 -9.068  -23.136 1.00 71.98  ?  255 MET B CB  1 
ATOM   5653 C  CG  . MET B 1 255 ? -77.161 -9.211  -24.588 1.00 72.67  ?  255 MET B CG  1 
ATOM   5654 S  SD  . MET B 1 255 ? -76.406 -10.823 -24.894 1.00 75.26  ?  255 MET B SD  1 
ATOM   5655 C  CE  . MET B 1 255 ? -77.784 -11.907 -24.526 1.00 76.74  ?  255 MET B CE  1 
ATOM   5656 N  N   . GLY B 1 256 ? -78.336 -7.261  -20.341 1.00 65.71  ?  256 GLY B N   1 
ATOM   5657 C  CA  . GLY B 1 256 ? -78.965 -7.417  -19.015 1.00 66.42  ?  256 GLY B CA  1 
ATOM   5658 C  C   . GLY B 1 256 ? -78.634 -8.763  -18.389 1.00 65.89  ?  256 GLY B C   1 
ATOM   5659 O  O   . GLY B 1 256 ? -79.292 -9.131  -17.396 1.00 67.21  ?  256 GLY B O   1 
ATOM   5660 N  N   . VAL B 1 257 ? -77.640 -9.466  -18.940 1.00 68.11  ?  257 VAL B N   1 
ATOM   5661 C  CA  . VAL B 1 257 ? -77.153 -10.787 -18.438 1.00 70.54  ?  257 VAL B CA  1 
ATOM   5662 C  C   . VAL B 1 257 ? -76.016 -10.537 -17.440 1.00 69.98  ?  257 VAL B C   1 
ATOM   5663 O  O   . VAL B 1 257 ? -75.097 -9.758  -17.770 1.00 72.10  ?  257 VAL B O   1 
ATOM   5664 C  CB  . VAL B 1 257 ? -76.705 -11.702 -19.594 1.00 70.28  ?  257 VAL B CB  1 
ATOM   5665 C  CG1 . VAL B 1 257 ? -76.175 -13.037 -19.092 1.00 68.60  ?  257 VAL B CG1 1 
ATOM   5666 C  CG2 . VAL B 1 257 ? -77.825 -11.918 -20.601 1.00 71.33  ?  257 VAL B CG2 1 
ATOM   5667 N  N   . ALA B 1 258 ? -76.092 -11.187 -16.275 1.00 68.27  ?  258 ALA B N   1 
ATOM   5668 C  CA  . ALA B 1 258 ? -75.144 -11.062 -15.143 1.00 68.97  ?  258 ALA B CA  1 
ATOM   5669 C  C   . ALA B 1 258 ? -74.305 -12.335 -15.018 1.00 70.06  ?  258 ALA B C   1 
ATOM   5670 O  O   . ALA B 1 258 ? -73.101 -12.222 -14.746 1.00 75.95  ?  258 ALA B O   1 
ATOM   5671 C  CB  . ALA B 1 258 ? -75.904 -10.798 -13.869 1.00 72.08  ?  258 ALA B CB  1 
ATOM   5672 N  N   . ALA B 1 259 ? -74.934 -13.499 -15.166 1.00 68.84  ?  259 ALA B N   1 
ATOM   5673 C  CA  . ALA B 1 259 ? -74.267 -14.820 -15.129 1.00 68.24  ?  259 ALA B CA  1 
ATOM   5674 C  C   . ALA B 1 259 ? -74.539 -15.566 -16.436 1.00 67.23  ?  259 ALA B C   1 
ATOM   5675 O  O   . ALA B 1 259 ? -75.511 -15.218 -17.121 1.00 68.98  ?  259 ALA B O   1 
ATOM   5676 C  CB  . ALA B 1 259 ? -74.747 -15.606 -13.936 1.00 68.53  ?  259 ALA B CB  1 
ATOM   5677 N  N   . SER B 1 260 ? -73.699 -16.547 -16.765 1.00 64.86  ?  260 SER B N   1 
ATOM   5678 C  CA  . SER B 1 260 ? -73.936 -17.493 -17.885 1.00 65.22  ?  260 SER B CA  1 
ATOM   5679 C  C   . SER B 1 260 ? -73.236 -18.825 -17.603 1.00 66.54  ?  260 SER B C   1 
ATOM   5680 O  O   . SER B 1 260 ? -72.202 -18.817 -16.914 1.00 69.66  ?  260 SER B O   1 
ATOM   5681 C  CB  . SER B 1 260 ? -73.511 -16.904 -19.210 1.00 66.39  ?  260 SER B CB  1 
ATOM   5682 O  OG  . SER B 1 260 ? -72.099 -16.857 -19.331 1.00 68.40  ?  260 SER B OG  1 
ATOM   5683 N  N   . MET B 1 261 ? -73.820 -19.925 -18.079 1.00 67.65  ?  261 MET B N   1 
ATOM   5684 C  CA  . MET B 1 261 ? -73.128 -21.231 -18.230 1.00 70.59  ?  261 MET B CA  1 
ATOM   5685 C  C   . MET B 1 261 ? -73.257 -21.668 -19.688 1.00 68.33  ?  261 MET B C   1 
ATOM   5686 O  O   . MET B 1 261 ? -74.320 -21.438 -20.285 1.00 70.70  ?  261 MET B O   1 
ATOM   5687 C  CB  . MET B 1 261 ? -73.713 -22.321 -17.329 1.00 74.60  ?  261 MET B CB  1 
ATOM   5688 C  CG  . MET B 1 261 ? -72.944 -23.628 -17.419 1.00 78.92  ?  261 MET B CG  1 
ATOM   5689 S  SD  . MET B 1 261 ? -73.772 -24.988 -16.577 1.00 87.86  ?  261 MET B SD  1 
ATOM   5690 C  CE  . MET B 1 261 ? -75.157 -25.251 -17.682 1.00 85.47  ?  261 MET B CE  1 
ATOM   5691 N  N   . SER B 1 262 ? -72.204 -22.277 -20.224 1.00 66.85  ?  262 SER B N   1 
ATOM   5692 C  CA  . SER B 1 262 ? -72.141 -22.742 -21.632 1.00 66.13  ?  262 SER B CA  1 
ATOM   5693 C  C   . SER B 1 262 ? -71.601 -24.175 -21.654 1.00 62.08  ?  262 SER B C   1 
ATOM   5694 O  O   . SER B 1 262 ? -70.527 -24.404 -21.079 1.00 61.83  ?  262 SER B O   1 
ATOM   5695 C  CB  . SER B 1 262 ? -71.330 -21.782 -22.465 1.00 69.72  ?  262 SER B CB  1 
ATOM   5696 O  OG  . SER B 1 262 ? -70.941 -22.363 -23.700 1.00 78.61  ?  262 SER B OG  1 
ATOM   5697 N  N   . ILE B 1 263 ? -72.360 -25.106 -22.240 1.00 58.97  ?  263 ILE B N   1 
ATOM   5698 C  CA  . ILE B 1 263 ? -71.957 -26.530 -22.438 1.00 57.35  ?  263 ILE B CA  1 
ATOM   5699 C  C   . ILE B 1 263 ? -71.583 -26.709 -23.911 1.00 56.41  ?  263 ILE B C   1 
ATOM   5700 O  O   . ILE B 1 263 ? -72.405 -26.360 -24.771 1.00 59.35  ?  263 ILE B O   1 
ATOM   5701 C  CB  . ILE B 1 263 ? -73.074 -27.497 -22.000 1.00 56.81  ?  263 ILE B CB  1 
ATOM   5702 C  CG1 . ILE B 1 263 ? -73.542 -27.207 -20.572 1.00 59.56  ?  263 ILE B CG1 1 
ATOM   5703 C  CG2 . ILE B 1 263 ? -72.625 -28.940 -22.158 1.00 57.40  ?  263 ILE B CG2 1 
ATOM   5704 C  CD1 . ILE B 1 263 ? -74.751 -28.005 -20.131 1.00 61.17  ?  263 ILE B CD1 1 
ATOM   5705 N  N   . SER B 1 264 ? -70.377 -27.209 -24.186 1.00 56.80  ?  264 SER B N   1 
ATOM   5706 C  CA  . SER B 1 264 ? -69.886 -27.463 -25.570 1.00 57.57  ?  264 SER B CA  1 
ATOM   5707 C  C   . SER B 1 264 ? -70.550 -28.729 -26.118 1.00 56.99  ?  264 SER B C   1 
ATOM   5708 O  O   . SER B 1 264 ? -70.564 -29.748 -25.398 1.00 59.91  ?  264 SER B O   1 
ATOM   5709 C  CB  . SER B 1 264 ? -68.392 -27.564 -25.635 1.00 57.97  ?  264 SER B CB  1 
ATOM   5710 O  OG  . SER B 1 264 ? -67.797 -26.310 -25.349 1.00 57.90  ?  264 SER B OG  1 
ATOM   5711 N  N   . VAL B 1 265 ? -71.107 -28.642 -27.329 1.00 54.44  ?  265 VAL B N   1 
ATOM   5712 C  CA  . VAL B 1 265 ? -71.726 -29.785 -28.060 1.00 52.70  ?  265 VAL B CA  1 
ATOM   5713 C  C   . VAL B 1 265 ? -70.712 -30.257 -29.107 1.00 54.34  ?  265 VAL B C   1 
ATOM   5714 O  O   . VAL B 1 265 ? -70.562 -29.578 -30.153 1.00 51.73  ?  265 VAL B O   1 
ATOM   5715 C  CB  . VAL B 1 265 ? -73.083 -29.401 -28.681 1.00 52.70  ?  265 VAL B CB  1 
ATOM   5716 C  CG1 . VAL B 1 265 ? -73.701 -30.553 -29.462 1.00 53.18  ?  265 VAL B CG1 1 
ATOM   5717 C  CG2 . VAL B 1 265 ? -74.053 -28.897 -27.623 1.00 52.40  ?  265 VAL B CG2 1 
ATOM   5718 N  N   . ILE B 1 266 ? -70.008 -31.348 -28.795 1.00 54.39  ?  266 ILE B N   1 
ATOM   5719 C  CA  . ILE B 1 266 ? -68.990 -31.982 -29.682 1.00 55.68  ?  266 ILE B CA  1 
ATOM   5720 C  C   . ILE B 1 266 ? -69.700 -33.076 -30.483 1.00 55.58  ?  266 ILE B C   1 
ATOM   5721 O  O   . ILE B 1 266 ? -70.234 -34.007 -29.856 1.00 57.16  ?  266 ILE B O   1 
ATOM   5722 C  CB  . ILE B 1 266 ? -67.798 -32.548 -28.879 1.00 57.40  ?  266 ILE B CB  1 
ATOM   5723 C  CG1 . ILE B 1 266 ? -67.320 -31.600 -27.774 1.00 58.16  ?  266 ILE B CG1 1 
ATOM   5724 C  CG2 . ILE B 1 266 ? -66.659 -32.933 -29.812 1.00 57.13  ?  266 ILE B CG2 1 
ATOM   5725 C  CD1 . ILE B 1 266 ? -67.009 -30.201 -28.246 1.00 60.40  ?  266 ILE B CD1 1 
ATOM   5726 N  N   . VAL B 1 267 ? -69.712 -32.947 -31.810 1.00 54.11  ?  267 VAL B N   1 
ATOM   5727 C  CA  . VAL B 1 267 ? -70.233 -33.970 -32.761 1.00 55.43  ?  267 VAL B CA  1 
ATOM   5728 C  C   . VAL B 1 267 ? -69.149 -34.222 -33.814 1.00 59.25  ?  267 VAL B C   1 
ATOM   5729 O  O   . VAL B 1 267 ? -68.784 -33.259 -34.521 1.00 60.79  ?  267 VAL B O   1 
ATOM   5730 C  CB  . VAL B 1 267 ? -71.559 -33.510 -33.395 1.00 56.70  ?  267 VAL B CB  1 
ATOM   5731 C  CG1 . VAL B 1 267 ? -72.014 -34.434 -34.517 1.00 56.33  ?  267 VAL B CG1 1 
ATOM   5732 C  CG2 . VAL B 1 267 ? -72.653 -33.357 -32.347 1.00 55.53  ?  267 VAL B CG2 1 
ATOM   5733 N  N   . ASP B 1 268 ? -68.653 -35.462 -33.886 1.00 62.34  ?  268 ASP B N   1 
ATOM   5734 C  CA  . ASP B 1 268 ? -67.572 -35.905 -34.808 1.00 65.11  ?  268 ASP B CA  1 
ATOM   5735 C  C   . ASP B 1 268 ? -66.305 -35.094 -34.513 1.00 66.45  ?  268 ASP B C   1 
ATOM   5736 O  O   . ASP B 1 268 ? -65.687 -34.585 -35.468 1.00 68.15  ?  268 ASP B O   1 
ATOM   5737 C  CB  . ASP B 1 268 ? -68.018 -35.799 -36.271 1.00 68.05  ?  268 ASP B CB  1 
ATOM   5738 C  CG  . ASP B 1 268 ? -69.283 -36.583 -36.587 1.00 71.51  ?  268 ASP B CG  1 
ATOM   5739 O  OD1 . ASP B 1 268 ? -69.399 -37.735 -36.110 1.00 73.72  ?  268 ASP B OD1 1 
ATOM   5740 O  OD2 . ASP B 1 268 ? -70.147 -36.036 -37.303 1.00 72.71  ?  268 ASP B OD2 1 
ATOM   5741 N  N   . ASP B 1 269 ? -65.950 -34.970 -33.230 1.00 69.76  ?  269 ASP B N   1 
ATOM   5742 C  CA  . ASP B 1 269 ? -64.708 -34.300 -32.751 1.00 70.92  ?  269 ASP B CA  1 
ATOM   5743 C  C   . ASP B 1 269 ? -64.656 -32.857 -33.268 1.00 66.90  ?  269 ASP B C   1 
ATOM   5744 O  O   . ASP B 1 269 ? -63.539 -32.346 -33.472 1.00 69.85  ?  269 ASP B O   1 
ATOM   5745 C  CB  . ASP B 1 269 ? -63.464 -35.073 -33.197 1.00 73.35  ?  269 ASP B CB  1 
ATOM   5746 C  CG  . ASP B 1 269 ? -63.558 -36.567 -32.946 1.00 75.60  ?  269 ASP B CG  1 
ATOM   5747 O  OD1 . ASP B 1 269 ? -63.622 -36.955 -31.765 1.00 77.04  ?  269 ASP B OD1 1 
ATOM   5748 O  OD2 . ASP B 1 269 ? -63.589 -37.325 -33.935 1.00 77.48  ?  269 ASP B OD2 1 
ATOM   5749 N  N   . ALA B 1 270 ? -65.820 -32.233 -33.471 1.00 62.17  ?  270 ALA B N   1 
ATOM   5750 C  CA  . ALA B 1 270 ? -65.965 -30.849 -33.983 1.00 59.43  ?  270 ALA B CA  1 
ATOM   5751 C  C   . ALA B 1 270 ? -66.973 -30.091 -33.118 1.00 56.83  ?  270 ALA B C   1 
ATOM   5752 O  O   . ALA B 1 270 ? -67.941 -30.716 -32.656 1.00 57.69  ?  270 ALA B O   1 
ATOM   5753 C  CB  . ALA B 1 270 ? -66.392 -30.871 -35.427 1.00 59.12  ?  270 ALA B CB  1 
ATOM   5754 N  N   . LEU B 1 271 ? -66.737 -28.795 -32.904 1.00 55.61  ?  271 LEU B N   1 
ATOM   5755 C  CA  . LEU B 1 271 ? -67.635 -27.913 -32.115 1.00 53.88  ?  271 LEU B CA  1 
ATOM   5756 C  C   . LEU B 1 271 ? -68.897 -27.652 -32.940 1.00 53.46  ?  271 LEU B C   1 
ATOM   5757 O  O   . LEU B 1 271 ? -68.878 -26.735 -33.786 1.00 53.79  ?  271 LEU B O   1 
ATOM   5758 C  CB  . LEU B 1 271 ? -66.913 -26.610 -31.760 1.00 52.26  ?  271 LEU B CB  1 
ATOM   5759 C  CG  . LEU B 1 271 ? -67.591 -25.761 -30.687 1.00 52.29  ?  271 LEU B CG  1 
ATOM   5760 C  CD1 . LEU B 1 271 ? -67.633 -26.489 -29.349 1.00 53.46  ?  271 LEU B CD1 1 
ATOM   5761 C  CD2 . LEU B 1 271 ? -66.884 -24.427 -30.536 1.00 52.21  ?  271 LEU B CD2 1 
ATOM   5762 N  N   . TRP B 1 272 ? -69.933 -28.464 -32.717 1.00 51.87  ?  272 TRP B N   1 
ATOM   5763 C  CA  . TRP B 1 272 ? -71.235 -28.379 -33.428 1.00 52.29  ?  272 TRP B CA  1 
ATOM   5764 C  C   . TRP B 1 272 ? -71.950 -27.091 -33.008 1.00 53.55  ?  272 TRP B C   1 
ATOM   5765 O  O   . TRP B 1 272 ? -72.551 -26.432 -33.877 1.00 56.20  ?  272 TRP B O   1 
ATOM   5766 C  CB  . TRP B 1 272 ? -72.085 -29.622 -33.140 1.00 51.03  ?  272 TRP B CB  1 
ATOM   5767 C  CG  . TRP B 1 272 ? -73.459 -29.584 -33.735 1.00 50.11  ?  272 TRP B CG  1 
ATOM   5768 C  CD1 . TRP B 1 272 ? -73.841 -30.083 -34.945 1.00 49.49  ?  272 TRP B CD1 1 
ATOM   5769 C  CD2 . TRP B 1 272 ? -74.643 -29.025 -33.138 1.00 49.56  ?  272 TRP B CD2 1 
ATOM   5770 N  NE1 . TRP B 1 272 ? -75.178 -29.869 -35.144 1.00 50.07  ?  272 TRP B NE1 1 
ATOM   5771 C  CE2 . TRP B 1 272 ? -75.697 -29.222 -34.054 1.00 49.30  ?  272 TRP B CE2 1 
ATOM   5772 C  CE3 . TRP B 1 272 ? -74.912 -28.370 -31.931 1.00 50.18  ?  272 TRP B CE3 1 
ATOM   5773 C  CZ2 . TRP B 1 272 ? -76.998 -28.796 -33.793 1.00 50.00  ?  272 TRP B CZ2 1 
ATOM   5774 C  CZ3 . TRP B 1 272 ? -76.197 -27.944 -31.676 1.00 50.87  ?  272 TRP B CZ3 1 
ATOM   5775 C  CH2 . TRP B 1 272 ? -77.225 -28.158 -32.595 1.00 51.32  ?  272 TRP B CH2 1 
ATOM   5776 N  N   . GLY B 1 273 ? -71.876 -26.757 -31.719 1.00 52.17  ?  273 GLY B N   1 
ATOM   5777 C  CA  . GLY B 1 273 ? -72.577 -25.603 -31.132 1.00 51.87  ?  273 GLY B CA  1 
ATOM   5778 C  C   . GLY B 1 273 ? -72.439 -25.568 -29.622 1.00 51.96  ?  273 GLY B C   1 
ATOM   5779 O  O   . GLY B 1 273 ? -71.537 -26.247 -29.093 1.00 51.77  ?  273 GLY B O   1 
ATOM   5780 N  N   . LEU B 1 274 ? -73.307 -24.803 -28.957 1.00 50.69  ?  274 LEU B N   1 
ATOM   5781 C  CA  . LEU B 1 274 ? -73.276 -24.594 -27.486 1.00 53.33  ?  274 LEU B CA  1 
ATOM   5782 C  C   . LEU B 1 274 ? -74.699 -24.671 -26.930 1.00 51.75  ?  274 LEU B C   1 
ATOM   5783 O  O   . LEU B 1 274 ? -75.626 -24.212 -27.610 1.00 51.38  ?  274 LEU B O   1 
ATOM   5784 C  CB  . LEU B 1 274 ? -72.658 -23.224 -27.180 1.00 54.99  ?  274 LEU B CB  1 
ATOM   5785 C  CG  . LEU B 1 274 ? -71.254 -22.981 -27.731 1.00 56.27  ?  274 LEU B CG  1 
ATOM   5786 C  CD1 . LEU B 1 274 ? -70.889 -21.510 -27.632 1.00 58.07  ?  274 LEU B CD1 1 
ATOM   5787 C  CD2 . LEU B 1 274 ? -70.224 -23.835 -27.008 1.00 55.68  ?  274 LEU B CD2 1 
ATOM   5788 N  N   . ILE B 1 275 ? -74.848 -25.254 -25.743 1.00 51.52  ?  275 ILE B N   1 
ATOM   5789 C  CA  . ILE B 1 275 ? -76.014 -25.024 -24.845 1.00 53.21  ?  275 ILE B CA  1 
ATOM   5790 C  C   . ILE B 1 275 ? -75.620 -23.850 -23.949 1.00 55.90  ?  275 ILE B C   1 
ATOM   5791 O  O   . ILE B 1 275 ? -74.743 -24.041 -23.087 1.00 57.63  ?  275 ILE B O   1 
ATOM   5792 C  CB  . ILE B 1 275 ? -76.369 -26.286 -24.033 1.00 53.64  ?  275 ILE B CB  1 
ATOM   5793 C  CG1 . ILE B 1 275 ? -76.704 -27.467 -24.946 1.00 52.25  ?  275 ILE B CG1 1 
ATOM   5794 C  CG2 . ILE B 1 275 ? -77.491 -25.999 -23.040 1.00 54.42  ?  275 ILE B CG2 1 
ATOM   5795 C  CD1 . ILE B 1 275 ? -76.731 -28.792 -24.231 1.00 53.78  ?  275 ILE B CD1 1 
ATOM   5796 N  N   . VAL B 1 276 ? -76.217 -22.681 -24.178 1.00 58.14  ?  276 VAL B N   1 
ATOM   5797 C  CA  . VAL B 1 276 ? -75.865 -21.417 -23.471 1.00 60.73  ?  276 VAL B CA  1 
ATOM   5798 C  C   . VAL B 1 276 ? -77.030 -21.011 -22.568 1.00 61.33  ?  276 VAL B C   1 
ATOM   5799 O  O   . VAL B 1 276 ? -78.118 -20.728 -23.095 1.00 65.95  ?  276 VAL B O   1 
ATOM   5800 C  CB  . VAL B 1 276 ? -75.491 -20.316 -24.478 1.00 63.20  ?  276 VAL B CB  1 
ATOM   5801 C  CG1 . VAL B 1 276 ? -75.462 -18.935 -23.838 1.00 64.93  ?  276 VAL B CG1 1 
ATOM   5802 C  CG2 . VAL B 1 276 ? -74.159 -20.641 -25.136 1.00 64.95  ?  276 VAL B CG2 1 
ATOM   5803 N  N   . CYS B 1 277 ? -76.784 -20.981 -21.258 1.00 61.27  ?  277 CYS B N   1 
ATOM   5804 C  CA  . CYS B 1 277 ? -77.737 -20.485 -20.229 1.00 62.82  ?  277 CYS B CA  1 
ATOM   5805 C  C   . CYS B 1 277 ? -77.349 -19.062 -19.810 1.00 62.84  ?  277 CYS B C   1 
ATOM   5806 O  O   . CYS B 1 277 ? -76.166 -18.842 -19.514 1.00 60.91  ?  277 CYS B O   1 
ATOM   5807 C  CB  . CYS B 1 277 ? -77.754 -21.399 -19.013 1.00 62.84  ?  277 CYS B CB  1 
ATOM   5808 S  SG  . CYS B 1 277 ? -77.666 -23.151 -19.457 1.00 63.52  ?  277 CYS B SG  1 
ATOM   5809 N  N   . HIS B 1 278 ? -78.319 -18.143 -19.805 1.00 64.05  ?  278 HIS B N   1 
ATOM   5810 C  CA  . HIS B 1 278 ? -78.210 -16.767 -19.252 1.00 62.54  ?  278 HIS B CA  1 
ATOM   5811 C  C   . HIS B 1 278 ? -79.029 -16.662 -17.962 1.00 63.32  ?  278 HIS B C   1 
ATOM   5812 O  O   . HIS B 1 278 ? -80.125 -17.245 -17.910 1.00 60.83  ?  278 HIS B O   1 
ATOM   5813 C  CB  . HIS B 1 278 ? -78.697 -15.726 -20.264 1.00 61.89  ?  278 HIS B CB  1 
ATOM   5814 C  CG  . HIS B 1 278 ? -77.898 -15.668 -21.518 1.00 61.71  ?  278 HIS B CG  1 
ATOM   5815 N  ND1 . HIS B 1 278 ? -78.465 -15.315 -22.724 1.00 62.88  ?  278 HIS B ND1 1 
ATOM   5816 C  CD2 . HIS B 1 278 ? -76.590 -15.905 -21.761 1.00 62.20  ?  278 HIS B CD2 1 
ATOM   5817 C  CE1 . HIS B 1 278 ? -77.541 -15.337 -23.661 1.00 64.01  ?  278 HIS B CE1 1 
ATOM   5818 N  NE2 . HIS B 1 278 ? -76.376 -15.691 -23.096 1.00 63.16  ?  278 HIS B NE2 1 
ATOM   5819 N  N   . HIS B 1 279 ? -78.499 -15.951 -16.962 1.00 67.70  ?  279 HIS B N   1 
ATOM   5820 C  CA  . HIS B 1 279 ? -79.239 -15.482 -15.759 1.00 68.75  ?  279 HIS B CA  1 
ATOM   5821 C  C   . HIS B 1 279 ? -79.109 -13.958 -15.678 1.00 71.07  ?  279 HIS B C   1 
ATOM   5822 O  O   . HIS B 1 279 ? -78.046 -13.435 -16.064 1.00 71.01  ?  279 HIS B O   1 
ATOM   5823 C  CB  . HIS B 1 279 ? -78.737 -16.192 -14.498 1.00 70.39  ?  279 HIS B CB  1 
ATOM   5824 C  CG  . HIS B 1 279 ? -79.809 -16.490 -13.503 1.00 73.19  ?  279 HIS B CG  1 
ATOM   5825 N  ND1 . HIS B 1 279 ? -80.979 -17.134 -13.851 1.00 74.87  ?  279 HIS B ND1 1 
ATOM   5826 C  CD2 . HIS B 1 279 ? -79.883 -16.266 -12.174 1.00 76.53  ?  279 HIS B CD2 1 
ATOM   5827 C  CE1 . HIS B 1 279 ? -81.733 -17.284 -12.782 1.00 76.20  ?  279 HIS B CE1 1 
ATOM   5828 N  NE2 . HIS B 1 279 ? -81.082 -16.763 -11.739 1.00 78.12  ?  279 HIS B NE2 1 
ATOM   5829 N  N   . CYS B 1 280 ? -80.166 -13.282 -15.224 1.00 75.55  ?  280 CYS B N   1 
ATOM   5830 C  CA  . CYS B 1 280 ? -80.274 -11.793 -15.194 1.00 74.90  ?  280 CYS B CA  1 
ATOM   5831 C  C   . CYS B 1 280 ? -79.733 -11.239 -13.872 1.00 73.27  ?  280 CYS B C   1 
ATOM   5832 O  O   . CYS B 1 280 ? -79.587 -10.007 -13.768 1.00 73.94  ?  280 CYS B O   1 
ATOM   5833 C  CB  . CYS B 1 280 ? -81.713 -11.345 -15.410 1.00 73.33  ?  280 CYS B CB  1 
ATOM   5834 S  SG  . CYS B 1 280 ? -82.324 -11.774 -17.058 1.00 72.56  ?  280 CYS B SG  1 
ATOM   5835 N  N   . SER B 1 281 ? -79.460 -12.123 -12.910 1.00 71.51  ?  281 SER B N   1 
ATOM   5836 C  CA  . SER B 1 281 ? -78.727 -11.819 -11.654 1.00 73.33  ?  281 SER B CA  1 
ATOM   5837 C  C   . SER B 1 281 ? -77.496 -12.718 -11.587 1.00 76.44  ?  281 SER B C   1 
ATOM   5838 O  O   . SER B 1 281 ? -77.413 -13.693 -12.330 1.00 79.00  ?  281 SER B O   1 
ATOM   5839 C  CB  . SER B 1 281 ? -79.625 -11.994 -10.451 1.00 71.88  ?  281 SER B CB  1 
ATOM   5840 O  OG  . SER B 1 281 ? -79.959 -13.359 -10.253 1.00 70.26  ?  281 SER B OG  1 
ATOM   5841 N  N   . PRO B 1 282 ? -76.498 -12.420 -10.721 1.00 78.81  ?  282 PRO B N   1 
ATOM   5842 C  CA  . PRO B 1 282 ? -75.415 -13.364 -10.435 1.00 77.23  ?  282 PRO B CA  1 
ATOM   5843 C  C   . PRO B 1 282 ? -75.909 -14.777 -10.093 1.00 75.20  ?  282 PRO B C   1 
ATOM   5844 O  O   . PRO B 1 282 ? -76.948 -14.896 -9.474  1.00 74.76  ?  282 PRO B O   1 
ATOM   5845 C  CB  . PRO B 1 282 ? -74.720 -12.735 -9.218  1.00 76.99  ?  282 PRO B CB  1 
ATOM   5846 C  CG  . PRO B 1 282 ? -74.946 -11.252 -9.406  1.00 79.04  ?  282 PRO B CG  1 
ATOM   5847 C  CD  . PRO B 1 282 ? -76.341 -11.152 -9.987  1.00 79.42  ?  282 PRO B CD  1 
ATOM   5848 N  N   . ARG B 1 283 ? -75.146 -15.797 -10.496 1.00 75.89  ?  283 ARG B N   1 
ATOM   5849 C  CA  . ARG B 1 283 ? -75.489 -17.229 -10.277 1.00 78.68  ?  283 ARG B CA  1 
ATOM   5850 C  C   . ARG B 1 283 ? -74.250 -18.098 -10.495 1.00 77.83  ?  283 ARG B C   1 
ATOM   5851 O  O   . ARG B 1 283 ? -73.624 -17.991 -11.572 1.00 76.29  ?  283 ARG B O   1 
ATOM   5852 C  CB  . ARG B 1 283 ? -76.605 -17.669 -11.229 1.00 81.98  ?  283 ARG B CB  1 
ATOM   5853 C  CG  . ARG B 1 283 ? -77.038 -19.119 -11.054 1.00 84.05  ?  283 ARG B CG  1 
ATOM   5854 C  CD  . ARG B 1 283 ? -78.199 -19.493 -11.953 1.00 88.37  ?  283 ARG B CD  1 
ATOM   5855 N  NE  . ARG B 1 283 ? -78.757 -20.786 -11.574 1.00 91.84  ?  283 ARG B NE  1 
ATOM   5856 C  CZ  . ARG B 1 283 ? -79.668 -20.979 -10.623 1.00 91.56  ?  283 ARG B CZ  1 
ATOM   5857 N  NH1 . ARG B 1 283 ? -80.157 -19.959 -9.935  1.00 94.66  ?  283 ARG B NH1 1 
ATOM   5858 N  NH2 . ARG B 1 283 ? -80.093 -22.203 -10.365 1.00 90.22  ?  283 ARG B NH2 1 
ATOM   5859 N  N   . VAL B 1 284 ? -73.950 -18.958 -9.522  1.00 77.63  ?  284 VAL B N   1 
ATOM   5860 C  CA  . VAL B 1 284 ? -72.801 -19.906 -9.576  1.00 80.00  ?  284 VAL B CA  1 
ATOM   5861 C  C   . VAL B 1 284 ? -73.329 -21.299 -9.226  1.00 77.44  ?  284 VAL B C   1 
ATOM   5862 O  O   . VAL B 1 284 ? -73.920 -21.458 -8.143  1.00 74.17  ?  284 VAL B O   1 
ATOM   5863 C  CB  . VAL B 1 284 ? -71.651 -19.466 -8.648  1.00 85.27  ?  284 VAL B CB  1 
ATOM   5864 C  CG1 . VAL B 1 284 ? -72.133 -18.561 -7.524  1.00 87.59  ?  284 VAL B CG1 1 
ATOM   5865 C  CG2 . VAL B 1 284 ? -70.880 -20.653 -8.085  1.00 85.89  ?  284 VAL B CG2 1 
ATOM   5866 N  N   . LEU B 1 285 ? -73.133 -22.258 -10.128 1.00 78.11  ?  285 LEU B N   1 
ATOM   5867 C  CA  . LEU B 1 285 ? -73.509 -23.677 -9.908  1.00 79.34  ?  285 LEU B CA  1 
ATOM   5868 C  C   . LEU B 1 285 ? -72.401 -24.363 -9.109  1.00 74.06  ?  285 LEU B C   1 
ATOM   5869 O  O   . LEU B 1 285 ? -71.231 -24.274 -9.529  1.00 71.06  ?  285 LEU B O   1 
ATOM   5870 C  CB  . LEU B 1 285 ? -73.715 -24.368 -11.258 1.00 85.74  ?  285 LEU B CB  1 
ATOM   5871 C  CG  . LEU B 1 285 ? -74.909 -23.887 -12.079 1.00 89.67  ?  285 LEU B CG  1 
ATOM   5872 C  CD1 . LEU B 1 285 ? -75.007 -24.679 -13.373 1.00 92.98  ?  285 LEU B CD1 1 
ATOM   5873 C  CD2 . LEU B 1 285 ? -76.206 -23.995 -11.288 1.00 91.18  ?  285 LEU B CD2 1 
ATOM   5874 N  N   . SER B 1 286 ? -72.769 -25.037 -8.017  1.00 71.22  ?  286 SER B N   1 
ATOM   5875 C  CA  . SER B 1 286 ? -71.844 -25.878 -7.212  1.00 72.84  ?  286 SER B CA  1 
ATOM   5876 C  C   . SER B 1 286 ? -71.185 -26.922 -8.125  1.00 72.24  ?  286 SER B C   1 
ATOM   5877 O  O   . SER B 1 286 ? -71.767 -27.241 -9.182  1.00 75.13  ?  286 SER B O   1 
ATOM   5878 C  CB  . SER B 1 286 ? -72.569 -26.524 -6.062  1.00 76.75  ?  286 SER B CB  1 
ATOM   5879 O  OG  . SER B 1 286 ? -73.569 -27.417 -6.531  1.00 79.59  ?  286 SER B OG  1 
ATOM   5880 N  N   . MET B 1 287 ? -70.019 -27.435 -7.729  1.00 69.59  ?  287 MET B N   1 
ATOM   5881 C  CA  . MET B 1 287 ? -69.215 -28.407 -8.519  1.00 70.37  ?  287 MET B CA  1 
ATOM   5882 C  C   . MET B 1 287 ? -70.061 -29.626 -8.893  1.00 71.02  ?  287 MET B C   1 
ATOM   5883 O  O   . MET B 1 287 ? -70.031 -30.050 -10.045 1.00 73.01  ?  287 MET B O   1 
ATOM   5884 C  CB  . MET B 1 287 ? -67.967 -28.853 -7.748  1.00 72.91  ?  287 MET B CB  1 
ATOM   5885 C  CG  . MET B 1 287 ? -67.335 -30.124 -8.292  1.00 75.45  ?  287 MET B CG  1 
ATOM   5886 S  SD  . MET B 1 287 ? -65.719 -30.477 -7.570  1.00 76.67  ?  287 MET B SD  1 
ATOM   5887 C  CE  . MET B 1 287 ? -64.742 -29.200 -8.363  1.00 77.93  ?  287 MET B CE  1 
ATOM   5888 N  N   . PRO B 1 288 ? -70.829 -30.241 -7.960  1.00 68.94  ?  288 PRO B N   1 
ATOM   5889 C  CA  . PRO B 1 288 ? -71.629 -31.426 -8.285  1.00 68.49  ?  288 PRO B CA  1 
ATOM   5890 C  C   . PRO B 1 288 ? -72.660 -31.198 -9.403  1.00 68.08  ?  288 PRO B C   1 
ATOM   5891 O  O   . PRO B 1 288 ? -72.803 -32.060 -10.248 1.00 70.53  ?  288 PRO B O   1 
ATOM   5892 C  CB  . PRO B 1 288 ? -72.361 -31.757 -6.977  1.00 68.37  ?  288 PRO B CB  1 
ATOM   5893 C  CG  . PRO B 1 288 ? -71.511 -31.113 -5.907  1.00 70.77  ?  288 PRO B CG  1 
ATOM   5894 C  CD  . PRO B 1 288 ? -70.970 -29.853 -6.549  1.00 69.83  ?  288 PRO B CD  1 
ATOM   5895 N  N   . VAL B 1 289 ? -73.346 -30.053 -9.373  1.00 67.09  ?  289 VAL B N   1 
ATOM   5896 C  CA  . VAL B 1 289 ? -74.354 -29.650 -10.400 1.00 67.21  ?  289 VAL B CA  1 
ATOM   5897 C  C   . VAL B 1 289 ? -73.629 -29.464 -11.737 1.00 65.86  ?  289 VAL B C   1 
ATOM   5898 O  O   . VAL B 1 289 ? -74.181 -29.886 -12.769 1.00 67.75  ?  289 VAL B O   1 
ATOM   5899 C  CB  . VAL B 1 289 ? -75.114 -28.376 -9.977  1.00 68.75  ?  289 VAL B CB  1 
ATOM   5900 C  CG1 . VAL B 1 289 ? -76.054 -27.879 -11.066 1.00 68.59  ?  289 VAL B CG1 1 
ATOM   5901 C  CG2 . VAL B 1 289 ? -75.876 -28.587 -8.677  1.00 68.96  ?  289 VAL B CG2 1 
ATOM   5902 N  N   . ARG B 1 290 ? -72.435 -28.862 -11.703 1.00 63.94  ?  290 ARG B N   1 
ATOM   5903 C  CA  . ARG B 1 290 ? -71.576 -28.657 -12.908 1.00 63.25  ?  290 ARG B CA  1 
ATOM   5904 C  C   . ARG B 1 290 ? -71.175 -30.014 -13.503 1.00 61.33  ?  290 ARG B C   1 
ATOM   5905 O  O   . ARG B 1 290 ? -71.148 -30.127 -14.744 1.00 58.21  ?  290 ARG B O   1 
ATOM   5906 C  CB  . ARG B 1 290 ? -70.333 -27.832 -12.562 1.00 65.08  ?  290 ARG B CB  1 
ATOM   5907 C  CG  . ARG B 1 290 ? -70.612 -26.347 -12.384 1.00 70.31  ?  290 ARG B CG  1 
ATOM   5908 C  CD  . ARG B 1 290 ? -69.417 -25.477 -12.732 1.00 73.84  ?  290 ARG B CD  1 
ATOM   5909 N  NE  . ARG B 1 290 ? -68.165 -25.962 -12.160 1.00 76.08  ?  290 ARG B NE  1 
ATOM   5910 C  CZ  . ARG B 1 290 ? -67.784 -25.792 -10.896 1.00 74.86  ?  290 ARG B CZ  1 
ATOM   5911 N  NH1 . ARG B 1 290 ? -68.564 -25.152 -10.039 1.00 73.99  ?  290 ARG B NH1 1 
ATOM   5912 N  NH2 . ARG B 1 290 ? -66.623 -26.276 -10.490 1.00 76.10  ?  290 ARG B NH2 1 
ATOM   5913 N  N   . ILE B 1 291 ? -70.863 -30.998 -12.654 1.00 60.43  ?  291 ILE B N   1 
ATOM   5914 C  CA  . ILE B 1 291 ? -70.493 -32.381 -13.083 1.00 59.66  ?  291 ILE B CA  1 
ATOM   5915 C  C   . ILE B 1 291 ? -71.700 -32.997 -13.800 1.00 60.52  ?  291 ILE B C   1 
ATOM   5916 O  O   . ILE B 1 291 ? -71.515 -33.533 -14.909 1.00 59.69  ?  291 ILE B O   1 
ATOM   5917 C  CB  . ILE B 1 291 ? -70.023 -33.227 -11.884 1.00 60.76  ?  291 ILE B CB  1 
ATOM   5918 C  CG1 . ILE B 1 291 ? -68.659 -32.757 -11.372 1.00 61.79  ?  291 ILE B CG1 1 
ATOM   5919 C  CG2 . ILE B 1 291 ? -70.006 -34.709 -12.231 1.00 61.63  ?  291 ILE B CG2 1 
ATOM   5920 C  CD1 . ILE B 1 291 ? -68.325 -33.229 -9.973  1.00 61.22  ?  291 ILE B CD1 1 
ATOM   5921 N  N   . ALA B 1 292 ? -72.885 -32.907 -13.188 1.00 59.04  ?  292 ALA B N   1 
ATOM   5922 C  CA  . ALA B 1 292 ? -74.171 -33.397 -13.740 1.00 57.06  ?  292 ALA B CA  1 
ATOM   5923 C  C   . ALA B 1 292 ? -74.403 -32.777 -15.120 1.00 57.56  ?  292 ALA B C   1 
ATOM   5924 O  O   . ALA B 1 292 ? -74.653 -33.534 -16.079 1.00 60.08  ?  292 ALA B O   1 
ATOM   5925 C  CB  . ALA B 1 292 ? -75.303 -33.068 -12.800 1.00 56.96  ?  292 ALA B CB  1 
ATOM   5926 N  N   . ALA B 1 293 ? -74.315 -31.447 -15.200 1.00 56.76  ?  293 ALA B N   1 
ATOM   5927 C  CA  . ALA B 1 293 ? -74.479 -30.646 -16.438 1.00 57.32  ?  293 ALA B CA  1 
ATOM   5928 C  C   . ALA B 1 293 ? -73.469 -31.092 -17.506 1.00 57.66  ?  293 ALA B C   1 
ATOM   5929 O  O   . ALA B 1 293 ? -73.842 -31.135 -18.691 1.00 57.30  ?  293 ALA B O   1 
ATOM   5930 C  CB  . ALA B 1 293 ? -74.331 -29.178 -16.121 1.00 57.75  ?  293 ALA B CB  1 
ATOM   5931 N  N   . ALA B 1 294 ? -72.235 -31.407 -17.104 1.00 59.90  ?  294 ALA B N   1 
ATOM   5932 C  CA  . ALA B 1 294 ? -71.138 -31.815 -18.014 1.00 60.30  ?  294 ALA B CA  1 
ATOM   5933 C  C   . ALA B 1 294 ? -71.424 -33.215 -18.565 1.00 60.12  ?  294 ALA B C   1 
ATOM   5934 O  O   . ALA B 1 294 ? -71.206 -33.420 -19.772 1.00 58.66  ?  294 ALA B O   1 
ATOM   5935 C  CB  . ALA B 1 294 ? -69.808 -31.762 -17.304 1.00 60.54  ?  294 ALA B CB  1 
ATOM   5936 N  N   . MET B 1 295 ? -71.889 -34.135 -17.711 1.00 62.83  ?  295 MET B N   1 
ATOM   5937 C  CA  . MET B 1 295 ? -72.278 -35.515 -18.112 1.00 67.22  ?  295 MET B CA  1 
ATOM   5938 C  C   . MET B 1 295 ? -73.438 -35.428 -19.107 1.00 62.56  ?  295 MET B C   1 
ATOM   5939 O  O   . MET B 1 295 ? -73.353 -36.063 -20.166 1.00 63.17  ?  295 MET B O   1 
ATOM   5940 C  CB  . MET B 1 295 ? -72.709 -36.367 -16.913 1.00 74.63  ?  295 MET B CB  1 
ATOM   5941 C  CG  . MET B 1 295 ? -71.587 -36.648 -15.931 1.00 81.77  ?  295 MET B CG  1 
ATOM   5942 S  SD  . MET B 1 295 ? -71.888 -38.124 -14.928 1.00 92.83  ?  295 MET B SD  1 
ATOM   5943 C  CE  . MET B 1 295 ? -71.343 -39.392 -16.073 1.00 91.67  ?  295 MET B CE  1 
ATOM   5944 N  N   . PHE B 1 296 ? -74.466 -34.641 -18.782 1.00 59.31  ?  296 PHE B N   1 
ATOM   5945 C  CA  . PHE B 1 296 ? -75.640 -34.393 -19.659 1.00 58.91  ?  296 PHE B CA  1 
ATOM   5946 C  C   . PHE B 1 296 ? -75.175 -33.923 -21.046 1.00 59.22  ?  296 PHE B C   1 
ATOM   5947 O  O   . PHE B 1 296 ? -75.725 -34.413 -22.056 1.00 61.11  ?  296 PHE B O   1 
ATOM   5948 C  CB  . PHE B 1 296 ? -76.598 -33.373 -19.039 1.00 57.16  ?  296 PHE B CB  1 
ATOM   5949 C  CG  . PHE B 1 296 ? -77.725 -33.001 -19.966 1.00 56.65  ?  296 PHE B CG  1 
ATOM   5950 C  CD1 . PHE B 1 296 ? -78.802 -33.853 -20.141 1.00 56.41  ?  296 PHE B CD1 1 
ATOM   5951 C  CD2 . PHE B 1 296 ? -77.676 -31.834 -20.713 1.00 57.05  ?  296 PHE B CD2 1 
ATOM   5952 C  CE1 . PHE B 1 296 ? -79.825 -33.530 -21.018 1.00 56.44  ?  296 PHE B CE1 1 
ATOM   5953 C  CE2 . PHE B 1 296 ? -78.699 -31.512 -21.590 1.00 56.54  ?  296 PHE B CE2 1 
ATOM   5954 C  CZ  . PHE B 1 296 ? -79.772 -32.360 -21.739 1.00 57.28  ?  296 PHE B CZ  1 
ATOM   5955 N  N   . GLY B 1 297 ? -74.216 -32.989 -21.086 1.00 57.88  ?  297 GLY B N   1 
ATOM   5956 C  CA  . GLY B 1 297 ? -73.633 -32.431 -22.323 1.00 55.83  ?  297 GLY B CA  1 
ATOM   5957 C  C   . GLY B 1 297 ? -72.969 -33.501 -23.178 1.00 58.37  ?  297 GLY B C   1 
ATOM   5958 O  O   . GLY B 1 297 ? -73.082 -33.419 -24.419 1.00 55.50  ?  297 GLY B O   1 
ATOM   5959 N  N   . GLU B 1 298 ? -72.295 -34.471 -22.549 1.00 60.68  ?  298 GLU B N   1 
ATOM   5960 C  CA  . GLU B 1 298 ? -71.605 -35.582 -23.261 1.00 65.03  ?  298 GLU B CA  1 
ATOM   5961 C  C   . GLU B 1 298 ? -72.652 -36.493 -23.912 1.00 61.52  ?  298 GLU B C   1 
ATOM   5962 O  O   . GLU B 1 298 ? -72.438 -36.895 -25.070 1.00 62.55  ?  298 GLU B O   1 
ATOM   5963 C  CB  . GLU B 1 298 ? -70.700 -36.373 -22.316 1.00 71.40  ?  298 GLU B CB  1 
ATOM   5964 C  CG  . GLU B 1 298 ? -69.446 -35.620 -21.913 1.00 80.40  ?  298 GLU B CG  1 
ATOM   5965 C  CD  . GLU B 1 298 ? -68.399 -36.471 -21.216 1.00 89.22  ?  298 GLU B CD  1 
ATOM   5966 O  OE1 . GLU B 1 298 ? -68.035 -36.139 -20.068 1.00 94.44  ?  298 GLU B OE1 1 
ATOM   5967 O  OE2 . GLU B 1 298 ? -67.948 -37.464 -21.826 1.00 97.48  ?  298 GLU B OE2 1 
ATOM   5968 N  N   . PHE B 1 299 ? -73.735 -36.798 -23.191 1.00 56.89  ?  299 PHE B N   1 
ATOM   5969 C  CA  . PHE B 1 299 ? -74.836 -37.685 -23.651 1.00 55.43  ?  299 PHE B CA  1 
ATOM   5970 C  C   . PHE B 1 299 ? -75.666 -36.968 -24.721 1.00 54.52  ?  299 PHE B C   1 
ATOM   5971 O  O   . PHE B 1 299 ? -75.923 -37.588 -25.770 1.00 57.22  ?  299 PHE B O   1 
ATOM   5972 C  CB  . PHE B 1 299 ? -75.676 -38.178 -22.470 1.00 55.53  ?  299 PHE B CB  1 
ATOM   5973 C  CG  . PHE B 1 299 ? -75.068 -39.360 -21.760 1.00 55.53  ?  299 PHE B CG  1 
ATOM   5974 C  CD1 . PHE B 1 299 ? -75.068 -40.614 -22.348 1.00 57.88  ?  299 PHE B CD1 1 
ATOM   5975 C  CD2 . PHE B 1 299 ? -74.467 -39.215 -20.521 1.00 56.76  ?  299 PHE B CD2 1 
ATOM   5976 C  CE1 . PHE B 1 299 ? -74.493 -41.699 -21.705 1.00 58.30  ?  299 PHE B CE1 1 
ATOM   5977 C  CE2 . PHE B 1 299 ? -73.896 -40.301 -19.876 1.00 56.65  ?  299 PHE B CE2 1 
ATOM   5978 C  CZ  . PHE B 1 299 ? -73.908 -41.540 -20.471 1.00 58.12  ?  299 PHE B CZ  1 
ATOM   5979 N  N   . PHE B 1 300 ? -76.061 -35.715 -24.474 1.00 52.13  ?  300 PHE B N   1 
ATOM   5980 C  CA  . PHE B 1 300 ? -76.751 -34.856 -25.473 1.00 50.83  ?  300 PHE B CA  1 
ATOM   5981 C  C   . PHE B 1 300 ? -75.959 -34.860 -26.784 1.00 50.30  ?  300 PHE B C   1 
ATOM   5982 O  O   . PHE B 1 300 ? -76.569 -34.994 -27.858 1.00 50.60  ?  300 PHE B O   1 
ATOM   5983 C  CB  . PHE B 1 300 ? -76.900 -33.412 -24.993 1.00 51.15  ?  300 PHE B CB  1 
ATOM   5984 C  CG  . PHE B 1 300 ? -77.477 -32.495 -26.042 1.00 50.45  ?  300 PHE B CG  1 
ATOM   5985 C  CD1 . PHE B 1 300 ? -78.848 -32.340 -26.175 1.00 50.41  ?  300 PHE B CD1 1 
ATOM   5986 C  CD2 . PHE B 1 300 ? -76.650 -31.814 -26.922 1.00 50.83  ?  300 PHE B CD2 1 
ATOM   5987 C  CE1 . PHE B 1 300 ? -79.375 -31.511 -27.153 1.00 51.86  ?  300 PHE B CE1 1 
ATOM   5988 C  CE2 . PHE B 1 300 ? -77.179 -30.984 -27.898 1.00 51.15  ?  300 PHE B CE2 1 
ATOM   5989 C  CZ  . PHE B 1 300 ? -78.540 -30.835 -28.014 1.00 51.39  ?  300 PHE B CZ  1 
ATOM   5990 N  N   . SER B 1 301 ? -74.640 -34.689 -26.678 1.00 51.43  ?  301 SER B N   1 
ATOM   5991 C  CA  . SER B 1 301 ? -73.692 -34.650 -27.828 1.00 50.85  ?  301 SER B CA  1 
ATOM   5992 C  C   . SER B 1 301 ? -73.702 -35.996 -28.560 1.00 50.95  ?  301 SER B C   1 
ATOM   5993 O  O   . SER B 1 301 ? -73.739 -35.989 -29.799 1.00 53.00  ?  301 SER B O   1 
ATOM   5994 C  CB  . SER B 1 301 ? -72.299 -34.288 -27.386 1.00 50.34  ?  301 SER B CB  1 
ATOM   5995 O  OG  . SER B 1 301 ? -72.200 -32.900 -27.112 1.00 49.12  ?  301 SER B OG  1 
ATOM   5996 N  N   . MET B 1 302 ? -73.671 -37.102 -27.814 1.00 52.42  ?  302 MET B N   1 
ATOM   5997 C  CA  . MET B 1 302 ? -73.628 -38.483 -28.369 1.00 53.62  ?  302 MET B CA  1 
ATOM   5998 C  C   . MET B 1 302 ? -74.941 -38.786 -29.104 1.00 53.75  ?  302 MET B C   1 
ATOM   5999 O  O   . MET B 1 302 ? -74.875 -39.280 -30.242 1.00 54.40  ?  302 MET B O   1 
ATOM   6000 C  CB  . MET B 1 302 ? -73.399 -39.516 -27.262 1.00 55.95  ?  302 MET B CB  1 
ATOM   6001 C  CG  . MET B 1 302 ? -71.939 -39.672 -26.886 1.00 57.49  ?  302 MET B CG  1 
ATOM   6002 S  SD  . MET B 1 302 ? -71.681 -40.948 -25.636 1.00 60.60  ?  302 MET B SD  1 
ATOM   6003 C  CE  . MET B 1 302 ? -71.688 -39.959 -24.143 1.00 60.33  ?  302 MET B CE  1 
ATOM   6004 N  N   . PHE B 1 303 ? -76.085 -38.486 -28.486 1.00 53.36  ?  303 PHE B N   1 
ATOM   6005 C  CA  . PHE B 1 303 ? -77.433 -38.771 -29.048 1.00 53.62  ?  303 PHE B CA  1 
ATOM   6006 C  C   . PHE B 1 303 ? -77.661 -37.928 -30.308 1.00 53.71  ?  303 PHE B C   1 
ATOM   6007 O  O   . PHE B 1 303 ? -78.207 -38.467 -31.289 1.00 55.68  ?  303 PHE B O   1 
ATOM   6008 C  CB  . PHE B 1 303 ? -78.524 -38.561 -27.993 1.00 53.27  ?  303 PHE B CB  1 
ATOM   6009 C  CG  . PHE B 1 303 ? -78.440 -39.495 -26.811 1.00 54.24  ?  303 PHE B CG  1 
ATOM   6010 C  CD1 . PHE B 1 303 ? -77.807 -40.727 -26.907 1.00 55.23  ?  303 PHE B CD1 1 
ATOM   6011 C  CD2 . PHE B 1 303 ? -79.013 -39.146 -25.599 1.00 56.08  ?  303 PHE B CD2 1 
ATOM   6012 C  CE1 . PHE B 1 303 ? -77.733 -41.578 -25.816 1.00 55.78  ?  303 PHE B CE1 1 
ATOM   6013 C  CE2 . PHE B 1 303 ? -78.938 -39.999 -24.509 1.00 57.71  ?  303 PHE B CE2 1 
ATOM   6014 C  CZ  . PHE B 1 303 ? -78.299 -41.212 -24.618 1.00 56.89  ?  303 PHE B CZ  1 
ATOM   6015 N  N   . LEU B 1 304 ? -77.254 -36.656 -30.284 1.00 52.28  ?  304 LEU B N   1 
ATOM   6016 C  CA  . LEU B 1 304 ? -77.366 -35.735 -31.447 1.00 52.12  ?  304 LEU B CA  1 
ATOM   6017 C  C   . LEU B 1 304 ? -76.546 -36.301 -32.608 1.00 51.00  ?  304 LEU B C   1 
ATOM   6018 O  O   . LEU B 1 304 ? -77.017 -36.244 -33.750 1.00 53.25  ?  304 LEU B O   1 
ATOM   6019 C  CB  . LEU B 1 304 ? -76.874 -34.339 -31.054 1.00 52.81  ?  304 LEU B CB  1 
ATOM   6020 C  CG  . LEU B 1 304 ? -76.815 -33.313 -32.185 1.00 52.68  ?  304 LEU B CG  1 
ATOM   6021 C  CD1 . LEU B 1 304 ? -78.171 -33.156 -32.856 1.00 52.78  ?  304 LEU B CD1 1 
ATOM   6022 C  CD2 . LEU B 1 304 ? -76.320 -31.973 -31.665 1.00 54.64  ?  304 LEU B CD2 1 
ATOM   6023 N  N   . GLN B 1 305 ? -75.367 -36.841 -32.315 1.00 50.14  ?  305 GLN B N   1 
ATOM   6024 C  CA  . GLN B 1 305 ? -74.455 -37.422 -33.334 1.00 52.20  ?  305 GLN B CA  1 
ATOM   6025 C  C   . GLN B 1 305 ? -75.134 -38.611 -34.026 1.00 52.18  ?  305 GLN B C   1 
ATOM   6026 O  O   . GLN B 1 305 ? -75.053 -38.688 -35.264 1.00 52.95  ?  305 GLN B O   1 
ATOM   6027 C  CB  . GLN B 1 305 ? -73.144 -37.841 -32.672 1.00 51.97  ?  305 GLN B CB  1 
ATOM   6028 C  CG  . GLN B 1 305 ? -72.158 -38.480 -33.632 1.00 52.95  ?  305 GLN B CG  1 
ATOM   6029 C  CD  . GLN B 1 305 ? -70.811 -38.613 -32.975 1.00 53.40  ?  305 GLN B CD  1 
ATOM   6030 O  OE1 . GLN B 1 305 ? -70.253 -37.637 -32.483 1.00 56.74  ?  305 GLN B OE1 1 
ATOM   6031 N  NE2 . GLN B 1 305 ? -70.291 -39.829 -32.941 1.00 55.84  ?  305 GLN B NE2 1 
ATOM   6032 N  N   . VAL B 1 306 ? -75.758 -39.505 -33.252 1.00 51.87  ?  306 VAL B N   1 
ATOM   6033 C  CA  . VAL B 1 306 ? -76.496 -40.699 -33.764 1.00 52.20  ?  306 VAL B CA  1 
ATOM   6034 C  C   . VAL B 1 306 ? -77.713 -40.231 -34.571 1.00 51.00  ?  306 VAL B C   1 
ATOM   6035 O  O   . VAL B 1 306 ? -77.898 -40.736 -35.694 1.00 51.92  ?  306 VAL B O   1 
ATOM   6036 C  CB  . VAL B 1 306 ? -76.915 -41.646 -32.622 1.00 52.93  ?  306 VAL B CB  1 
ATOM   6037 C  CG1 . VAL B 1 306 ? -77.867 -42.729 -33.106 1.00 54.69  ?  306 VAL B CG1 1 
ATOM   6038 C  CG2 . VAL B 1 306 ? -75.707 -42.274 -31.947 1.00 52.83  ?  306 VAL B CG2 1 
ATOM   6039 N  N   . LEU B 1 307 ? -78.516 -39.320 -34.012 1.00 50.14  ?  307 LEU B N   1 
ATOM   6040 C  CA  . LEU B 1 307 ? -79.753 -38.798 -34.657 1.00 51.51  ?  307 LEU B CA  1 
ATOM   6041 C  C   . LEU B 1 307 ? -79.403 -38.095 -35.971 1.00 52.78  ?  307 LEU B C   1 
ATOM   6042 O  O   . LEU B 1 307 ? -80.181 -38.232 -36.932 1.00 54.72  ?  307 LEU B O   1 
ATOM   6043 C  CB  . LEU B 1 307 ? -80.474 -37.846 -33.699 1.00 51.06  ?  307 LEU B CB  1 
ATOM   6044 C  CG  . LEU B 1 307 ? -81.242 -38.524 -32.565 1.00 52.30  ?  307 LEU B CG  1 
ATOM   6045 C  CD1 . LEU B 1 307 ? -81.814 -37.487 -31.613 1.00 52.93  ?  307 LEU B CD1 1 
ATOM   6046 C  CD2 . LEU B 1 307 ? -82.349 -39.420 -33.103 1.00 52.23  ?  307 LEU B CD2 1 
ATOM   6047 N  N   . LYS B 1 308 ? -78.284 -37.370 -35.995 1.00 56.65  ?  308 LYS B N   1 
ATOM   6048 C  CA  . LYS B 1 308 ? -77.762 -36.642 -37.185 1.00 61.44  ?  308 LYS B CA  1 
ATOM   6049 C  C   . LYS B 1 308 ? -77.368 -37.662 -38.257 1.00 60.09  ?  308 LYS B C   1 
ATOM   6050 O  O   . LYS B 1 308 ? -77.664 -37.415 -39.442 1.00 60.19  ?  308 LYS B O   1 
ATOM   6051 C  CB  . LYS B 1 308 ? -76.569 -35.770 -36.779 1.00 67.11  ?  308 LYS B CB  1 
ATOM   6052 C  CG  . LYS B 1 308 ? -76.274 -34.576 -37.673 1.00 72.30  ?  308 LYS B CG  1 
ATOM   6053 C  CD  . LYS B 1 308 ? -75.315 -33.595 -37.023 1.00 76.09  ?  308 LYS B CD  1 
ATOM   6054 C  CE  . LYS B 1 308 ? -74.881 -32.471 -37.940 1.00 79.99  ?  308 LYS B CE  1 
ATOM   6055 N  NZ  . LYS B 1 308 ? -73.904 -32.938 -38.953 1.00 84.28  ?  308 LYS B NZ  1 
ATOM   6056 N  N   . GLN B 1 309 ? -76.730 -38.760 -37.837 1.00 61.78  ?  309 GLN B N   1 
ATOM   6057 C  CA  . GLN B 1 309 ? -76.308 -39.894 -38.706 1.00 63.86  ?  309 GLN B CA  1 
ATOM   6058 C  C   . GLN B 1 309 ? -77.553 -40.564 -39.301 1.00 62.64  ?  309 GLN B C   1 
ATOM   6059 O  O   . GLN B 1 309 ? -77.539 -40.846 -40.510 1.00 63.04  ?  309 GLN B O   1 
ATOM   6060 C  CB  . GLN B 1 309 ? -75.456 -40.893 -37.915 1.00 66.83  ?  309 GLN B CB  1 
ATOM   6061 C  CG  . GLN B 1 309 ? -74.970 -42.080 -38.738 1.00 71.54  ?  309 GLN B CG  1 
ATOM   6062 C  CD  . GLN B 1 309 ? -74.294 -43.150 -37.911 1.00 75.80  ?  309 GLN B CD  1 
ATOM   6063 O  OE1 . GLN B 1 309 ? -74.800 -43.589 -36.879 1.00 76.04  ?  309 GLN B OE1 1 
ATOM   6064 N  NE2 . GLN B 1 309 ? -73.143 -43.607 -38.375 1.00 78.86  ?  309 GLN B NE2 1 
ATOM   6065 N  N   . LYS B 1 310 ? -78.582 -40.807 -38.484 1.00 62.51  ?  310 LYS B N   1 
ATOM   6066 C  CA  . LYS B 1 310 ? -79.848 -41.463 -38.916 1.00 64.59  ?  310 LYS B CA  1 
ATOM   6067 C  C   . LYS B 1 310 ? -80.545 -40.597 -39.971 1.00 62.47  ?  310 LYS B C   1 
ATOM   6068 O  O   . LYS B 1 310 ? -81.061 -41.170 -40.942 1.00 63.11  ?  310 LYS B O   1 
ATOM   6069 C  CB  . LYS B 1 310 ? -80.768 -41.748 -37.724 1.00 68.35  ?  310 LYS B CB  1 
ATOM   6070 C  CG  . LYS B 1 310 ? -80.619 -43.145 -37.136 1.00 75.62  ?  310 LYS B CG  1 
ATOM   6071 C  CD  . LYS B 1 310 ? -81.285 -43.348 -35.784 1.00 81.53  ?  310 LYS B CD  1 
ATOM   6072 C  CE  . LYS B 1 310 ? -80.806 -44.607 -35.087 1.00 83.84  ?  310 LYS B CE  1 
ATOM   6073 N  NZ  . LYS B 1 310 ? -81.584 -44.908 -33.862 1.00 85.77  ?  310 LYS B NZ  1 
ATOM   6074 N  N   . ARG B 1 311 ? -80.565 -39.274 -39.788 1.00 63.27  ?  311 ARG B N   1 
ATOM   6075 C  CA  . ARG B 1 311 ? -81.237 -38.338 -40.733 1.00 64.79  ?  311 ARG B CA  1 
ATOM   6076 C  C   . ARG B 1 311 ? -80.513 -38.384 -42.081 1.00 62.80  ?  311 ARG B C   1 
ATOM   6077 O  O   . ARG B 1 311 ? -81.193 -38.408 -43.122 1.00 62.79  ?  311 ARG B O   1 
ATOM   6078 C  CB  . ARG B 1 311 ? -81.263 -36.907 -40.188 1.00 69.73  ?  311 ARG B CB  1 
ATOM   6079 C  CG  . ARG B 1 311 ? -82.108 -35.952 -41.022 1.00 76.25  ?  311 ARG B CG  1 
ATOM   6080 C  CD  . ARG B 1 311 ? -82.185 -34.567 -40.417 1.00 83.60  ?  311 ARG B CD  1 
ATOM   6081 N  NE  . ARG B 1 311 ? -80.860 -33.970 -40.306 1.00 91.91  ?  311 ARG B NE  1 
ATOM   6082 C  CZ  . ARG B 1 311 ? -80.531 -32.966 -39.494 1.00 96.23  ?  311 ARG B CZ  1 
ATOM   6083 N  NH1 . ARG B 1 311 ? -81.432 -32.418 -38.693 1.00 95.80  ?  311 ARG B NH1 1 
ATOM   6084 N  NH2 . ARG B 1 311 ? -79.286 -32.518 -39.486 1.00 97.41  ?  311 ARG B NH2 1 
ATOM   6085 N  N   . ARG B 1 312 ? -79.182 -38.401 -42.051 1.00 63.30  ?  312 ARG B N   1 
ATOM   6086 C  CA  . ARG B 1 312 ? -78.347 -38.463 -43.283 1.00 67.40  ?  312 ARG B CA  1 
ATOM   6087 C  C   . ARG B 1 312 ? -78.705 -39.738 -44.058 1.00 64.09  ?  312 ARG B C   1 
ATOM   6088 O  O   . ARG B 1 312 ? -78.910 -39.640 -45.283 1.00 64.44  ?  312 ARG B O   1 
ATOM   6089 C  CB  . ARG B 1 312 ? -76.857 -38.406 -42.932 1.00 73.22  ?  312 ARG B CB  1 
ATOM   6090 C  CG  . ARG B 1 312 ? -75.976 -37.869 -44.050 1.00 78.94  ?  312 ARG B CG  1 
ATOM   6091 C  CD  . ARG B 1 312 ? -74.554 -37.625 -43.582 1.00 85.29  ?  312 ARG B CD  1 
ATOM   6092 N  NE  . ARG B 1 312 ? -73.782 -36.848 -44.545 1.00 91.53  ?  312 ARG B NE  1 
ATOM   6093 C  CZ  . ARG B 1 312 ? -73.243 -37.327 -45.665 1.00 96.25  ?  312 ARG B CZ  1 
ATOM   6094 N  NH1 . ARG B 1 312 ? -73.387 -38.601 -45.997 1.00 98.53  ?  312 ARG B NH1 1 
ATOM   6095 N  NH2 . ARG B 1 312 ? -72.557 -36.521 -46.457 1.00 96.66  ?  312 ARG B NH2 1 
ATOM   6096 N  N   . LEU B 1 313 ? -78.794 -40.877 -43.361 1.00 61.65  ?  313 LEU B N   1 
ATOM   6097 C  CA  . LEU B 1 313 ? -79.146 -42.199 -43.951 1.00 61.14  ?  313 LEU B CA  1 
ATOM   6098 C  C   . LEU B 1 313 ? -80.521 -42.117 -44.615 1.00 57.05  ?  313 LEU B C   1 
ATOM   6099 O  O   . LEU B 1 313 ? -80.615 -42.471 -45.798 1.00 54.45  ?  313 LEU B O   1 
ATOM   6100 C  CB  . LEU B 1 313 ? -79.162 -43.276 -42.864 1.00 64.95  ?  313 LEU B CB  1 
ATOM   6101 C  CG  . LEU B 1 313 ? -77.813 -43.633 -42.248 1.00 71.48  ?  313 LEU B CG  1 
ATOM   6102 C  CD1 . LEU B 1 313 ? -77.979 -44.780 -41.267 1.00 74.96  ?  313 LEU B CD1 1 
ATOM   6103 C  CD2 . LEU B 1 313 ? -76.780 -43.983 -43.311 1.00 72.47  ?  313 LEU B CD2 1 
ATOM   6104 N  N   . ASP B 1 314 ? -81.534 -41.687 -43.858 1.00 57.49  ?  314 ASP B N   1 
ATOM   6105 C  CA  . ASP B 1 314 ? -82.955 -41.627 -44.298 1.00 59.58  ?  314 ASP B CA  1 
ATOM   6106 C  C   . ASP B 1 314 ? -83.057 -40.738 -45.541 1.00 57.33  ?  314 ASP B C   1 
ATOM   6107 O  O   . ASP B 1 314 ? -83.705 -41.162 -46.514 1.00 62.26  ?  314 ASP B O   1 
ATOM   6108 C  CB  . ASP B 1 314 ? -83.878 -41.142 -43.177 1.00 62.09  ?  314 ASP B CB  1 
ATOM   6109 C  CG  . ASP B 1 314 ? -84.001 -42.106 -42.007 1.00 66.06  ?  314 ASP B CG  1 
ATOM   6110 O  OD1 . ASP B 1 314 ? -83.406 -43.204 -42.081 1.00 67.05  ?  314 ASP B OD1 1 
ATOM   6111 O  OD2 . ASP B 1 314 ? -84.685 -41.749 -41.023 1.00 72.11  -1 314 ASP B OD2 1 
ATOM   6112 N  N   . THR B 1 315 ? -82.428 -39.562 -45.507 1.00 54.63  ?  315 THR B N   1 
ATOM   6113 C  CA  . THR B 1 315 ? -82.419 -38.583 -46.631 1.00 54.66  ?  315 THR B CA  1 
ATOM   6114 C  C   . THR B 1 315 ? -81.864 -39.229 -47.905 1.00 53.71  ?  315 THR B C   1 
ATOM   6115 O  O   . THR B 1 315 ? -82.447 -38.996 -48.977 1.00 56.05  ?  315 THR B O   1 
ATOM   6116 C  CB  . THR B 1 315 ? -81.608 -37.334 -46.277 1.00 56.31  ?  315 THR B CB  1 
ATOM   6117 O  OG1 . THR B 1 315 ? -82.141 -36.822 -45.056 1.00 57.36  ?  315 THR B OG1 1 
ATOM   6118 C  CG2 . THR B 1 315 ? -81.659 -36.267 -47.348 1.00 57.65  ?  315 THR B CG2 1 
ATOM   6119 N  N   . ILE B 1 316 ? -80.773 -39.990 -47.792 1.00 54.64  ?  316 ILE B N   1 
ATOM   6120 C  CA  . ILE B 1 316 ? -80.056 -40.598 -48.955 1.00 56.89  ?  316 ILE B CA  1 
ATOM   6121 C  C   . ILE B 1 316 ? -80.814 -41.844 -49.436 1.00 56.95  ?  316 ILE B C   1 
ATOM   6122 O  O   . ILE B 1 316 ? -80.792 -42.100 -50.652 1.00 56.92  ?  316 ILE B O   1 
ATOM   6123 C  CB  . ILE B 1 316 ? -78.583 -40.880 -48.600 1.00 58.50  ?  316 ILE B CB  1 
ATOM   6124 C  CG1 . ILE B 1 316 ? -77.821 -39.569 -48.389 1.00 61.69  ?  316 ILE B CG1 1 
ATOM   6125 C  CG2 . ILE B 1 316 ? -77.921 -41.741 -49.662 1.00 59.42  ?  316 ILE B CG2 1 
ATOM   6126 C  CD1 . ILE B 1 316 ? -76.427 -39.737 -47.835 1.00 64.62  ?  316 ILE B CD1 1 
ATOM   6127 N  N   . ASN B 1 317 ? -81.473 -42.572 -48.529 1.00 60.56  ?  317 ASN B N   1 
ATOM   6128 C  CA  . ASN B 1 317 ? -82.356 -43.720 -48.870 1.00 64.54  ?  317 ASN B CA  1 
ATOM   6129 C  C   . ASN B 1 317 ? -83.546 -43.220 -49.688 1.00 65.30  ?  317 ASN B C   1 
ATOM   6130 O  O   . ASN B 1 317 ? -83.794 -43.795 -50.764 1.00 66.94  ?  317 ASN B O   1 
ATOM   6131 C  CB  . ASN B 1 317 ? -82.861 -44.470 -47.636 1.00 69.02  ?  317 ASN B CB  1 
ATOM   6132 C  CG  . ASN B 1 317 ? -81.983 -45.645 -47.268 1.00 75.03  ?  317 ASN B CG  1 
ATOM   6133 O  OD1 . ASN B 1 317 ? -81.648 -46.468 -48.118 1.00 79.64  ?  317 ASN B OD1 1 
ATOM   6134 N  ND2 . ASN B 1 317 ? -81.607 -45.728 -46.004 1.00 80.72  ?  317 ASN B ND2 1 
ATOM   6135 N  N   . HIS B 1 318 ? -84.257 -42.207 -49.181 1.00 68.48  ?  318 HIS B N   1 
ATOM   6136 C  CA  . HIS B 1 318 ? -85.413 -41.563 -49.862 1.00 71.37  ?  318 HIS B CA  1 
ATOM   6137 C  C   . HIS B 1 318 ? -85.014 -41.217 -51.299 1.00 66.18  ?  318 HIS B C   1 
ATOM   6138 O  O   . HIS B 1 318 ? -85.759 -41.582 -52.226 1.00 66.38  ?  318 HIS B O   1 
ATOM   6139 C  CB  . HIS B 1 318 ? -85.895 -40.320 -49.102 1.00 78.39  ?  318 HIS B CB  1 
ATOM   6140 C  CG  . HIS B 1 318 ? -87.058 -39.645 -49.752 1.00 91.45  ?  318 HIS B CG  1 
ATOM   6141 N  ND1 . HIS B 1 318 ? -86.991 -38.346 -50.228 1.00 97.43  ?  318 HIS B ND1 1 
ATOM   6142 C  CD2 . HIS B 1 318 ? -88.303 -40.089 -50.036 1.00 97.38  ?  318 HIS B CD2 1 
ATOM   6143 C  CE1 . HIS B 1 318 ? -88.150 -38.016 -50.763 1.00 100.69 ?  318 HIS B CE1 1 
ATOM   6144 N  NE2 . HIS B 1 318 ? -88.972 -39.069 -50.659 1.00 102.22 ?  318 HIS B NE2 1 
ATOM   6145 N  N   . ALA B 1 319 ? -83.871 -40.546 -51.456 1.00 61.30  ?  319 ALA B N   1 
ATOM   6146 C  CA  . ALA B 1 319 ? -83.307 -40.114 -52.754 1.00 59.99  ?  319 ALA B CA  1 
ATOM   6147 C  C   . ALA B 1 319 ? -83.090 -41.332 -53.658 1.00 58.67  ?  319 ALA B C   1 
ATOM   6148 O  O   . ALA B 1 319 ? -83.437 -41.249 -54.850 1.00 59.60  ?  319 ALA B O   1 
ATOM   6149 C  CB  . ALA B 1 319 ? -82.025 -39.356 -52.529 1.00 61.96  ?  319 ALA B CB  1 
ATOM   6150 N  N   . HIS B 1 320 ? -82.534 -42.414 -53.108 1.00 59.41  ?  320 HIS B N   1 
ATOM   6151 C  CA  . HIS B 1 320 ? -82.296 -43.695 -53.831 1.00 61.52  ?  320 HIS B CA  1 
ATOM   6152 C  C   . HIS B 1 320 ? -83.632 -44.308 -54.267 1.00 60.78  ?  320 HIS B C   1 
ATOM   6153 O  O   . HIS B 1 320 ? -83.728 -44.738 -55.431 1.00 62.15  ?  320 HIS B O   1 
ATOM   6154 C  CB  . HIS B 1 320 ? -81.454 -44.657 -52.983 1.00 62.49  ?  320 HIS B CB  1 
ATOM   6155 C  CG  . HIS B 1 320 ? -79.991 -44.411 -53.118 1.00 64.42  ?  320 HIS B CG  1 
ATOM   6156 N  ND1 . HIS B 1 320 ? -79.238 -43.859 -52.106 1.00 66.63  ?  320 HIS B ND1 1 
ATOM   6157 C  CD2 . HIS B 1 320 ? -79.149 -44.609 -54.152 1.00 65.52  ?  320 HIS B CD2 1 
ATOM   6158 C  CE1 . HIS B 1 320 ? -77.989 -43.740 -52.504 1.00 68.79  ?  320 HIS B CE1 1 
ATOM   6159 N  NE2 . HIS B 1 320 ? -77.908 -44.197 -53.756 1.00 68.13  ?  320 HIS B NE2 1 
ATOM   6160 N  N   . ALA B 1 321 ? -84.618 -44.336 -53.367 1.00 59.83  ?  321 ALA B N   1 
ATOM   6161 C  CA  . ALA B 1 321 ? -85.994 -44.823 -53.626 1.00 59.46  ?  321 ALA B CA  1 
ATOM   6162 C  C   . ALA B 1 321 ? -86.657 -43.970 -54.717 1.00 60.76  ?  321 ALA B C   1 
ATOM   6163 O  O   . ALA B 1 321 ? -87.281 -44.551 -55.625 1.00 64.98  ?  321 ALA B O   1 
ATOM   6164 C  CB  . ALA B 1 321 ? -86.799 -44.809 -52.350 1.00 58.77  ?  321 ALA B CB  1 
ATOM   6165 N  N   . ALA B 1 322 ? -86.526 -42.643 -54.628 1.00 59.09  ?  322 ALA B N   1 
ATOM   6166 C  CA  . ALA B 1 322 ? -87.128 -41.662 -55.565 1.00 58.43  ?  322 ALA B CA  1 
ATOM   6167 C  C   . ALA B 1 322 ? -86.526 -41.835 -56.964 1.00 59.49  ?  322 ALA B C   1 
ATOM   6168 O  O   . ALA B 1 322 ? -87.294 -41.821 -57.937 1.00 62.18  ?  322 ALA B O   1 
ATOM   6169 C  CB  . ALA B 1 322 ? -86.924 -40.259 -55.056 1.00 58.31  ?  322 ALA B CB  1 
ATOM   6170 N  N   . LEU B 1 323 ? -85.202 -41.981 -57.050 1.00 61.78  ?  323 LEU B N   1 
ATOM   6171 C  CA  . LEU B 1 323 ? -84.471 -42.195 -58.329 1.00 62.50  ?  323 LEU B CA  1 
ATOM   6172 C  C   . LEU B 1 323 ? -84.853 -43.559 -58.919 1.00 64.66  ?  323 LEU B C   1 
ATOM   6173 O  O   . LEU B 1 323 ? -84.957 -43.642 -60.154 1.00 67.07  ?  323 LEU B O   1 
ATOM   6174 C  CB  . LEU B 1 323 ? -82.960 -42.087 -58.092 1.00 62.04  ?  323 LEU B CB  1 
ATOM   6175 C  CG  . LEU B 1 323 ? -82.409 -40.666 -57.985 1.00 60.68  ?  323 LEU B CG  1 
ATOM   6176 C  CD1 . LEU B 1 323 ? -80.955 -40.677 -57.547 1.00 60.00  ?  323 LEU B CD1 1 
ATOM   6177 C  CD2 . LEU B 1 323 ? -82.556 -39.921 -59.303 1.00 61.77  ?  323 LEU B CD2 1 
ATOM   6178 N  N   . ASP B 1 324 ? -85.065 -44.579 -58.079 1.00 67.36  ?  324 ASP B N   1 
ATOM   6179 C  CA  . ASP B 1 324 ? -85.500 -45.931 -58.530 1.00 71.48  ?  324 ASP B CA  1 
ATOM   6180 C  C   . ASP B 1 324 ? -86.862 -45.807 -59.214 1.00 70.18  ?  324 ASP B C   1 
ATOM   6181 O  O   . ASP B 1 324 ? -87.013 -46.337 -60.330 1.00 71.82  ?  324 ASP B O   1 
ATOM   6182 C  CB  . ASP B 1 324 ? -85.588 -46.942 -57.384 1.00 75.41  ?  324 ASP B CB  1 
ATOM   6183 C  CG  . ASP B 1 324 ? -84.278 -47.640 -57.061 1.00 80.85  ?  324 ASP B CG  1 
ATOM   6184 O  OD1 . ASP B 1 324 ? -83.293 -47.424 -57.799 1.00 82.36  ?  324 ASP B OD1 1 
ATOM   6185 O  OD2 . ASP B 1 324 ? -84.254 -48.395 -56.069 1.00 88.30  ?  324 ASP B OD2 1 
ATOM   6186 N  N   . ARG B 1 325 ? -87.809 -45.133 -58.560 1.00 70.72  ?  325 ARG B N   1 
ATOM   6187 C  CA  . ARG B 1 325 ? -89.189 -44.949 -59.080 1.00 74.02  ?  325 ARG B CA  1 
ATOM   6188 C  C   . ARG B 1 325 ? -89.119 -44.261 -60.449 1.00 70.23  ?  325 ARG B C   1 
ATOM   6189 O  O   . ARG B 1 325 ? -89.839 -44.697 -61.368 1.00 72.79  ?  325 ARG B O   1 
ATOM   6190 C  CB  . ARG B 1 325 ? -90.048 -44.158 -58.089 1.00 81.50  ?  325 ARG B CB  1 
ATOM   6191 C  CG  . ARG B 1 325 ? -91.519 -44.547 -58.114 1.00 90.13  ?  325 ARG B CG  1 
ATOM   6192 C  CD  . ARG B 1 325 ? -92.429 -43.490 -57.519 1.00 98.54  ?  325 ARG B CD  1 
ATOM   6193 N  NE  . ARG B 1 325 ? -92.738 -42.416 -58.458 1.00 104.71 ?  325 ARG B NE  1 
ATOM   6194 C  CZ  . ARG B 1 325 ? -93.655 -42.475 -59.426 1.00 106.64 ?  325 ARG B CZ  1 
ATOM   6195 N  NH1 . ARG B 1 325 ? -93.850 -41.427 -60.209 1.00 107.92 ?  325 ARG B NH1 1 
ATOM   6196 N  NH2 . ARG B 1 325 ? -94.371 -43.571 -59.618 1.00 108.07 ?  325 ARG B NH2 1 
ATOM   6197 N  N   . PHE B 1 326 ? -88.266 -43.243 -60.584 1.00 66.40  ?  326 PHE B N   1 
ATOM   6198 C  CA  . PHE B 1 326 ? -88.087 -42.463 -61.837 1.00 66.99  ?  326 PHE B CA  1 
ATOM   6199 C  C   . PHE B 1 326 ? -87.497 -43.355 -62.936 1.00 66.96  ?  326 PHE B C   1 
ATOM   6200 O  O   . PHE B 1 326 ? -88.006 -43.308 -64.070 1.00 70.11  ?  326 PHE B O   1 
ATOM   6201 C  CB  . PHE B 1 326 ? -87.195 -41.241 -61.621 1.00 66.31  ?  326 PHE B CB  1 
ATOM   6202 C  CG  . PHE B 1 326 ? -86.941 -40.455 -62.881 1.00 65.54  ?  326 PHE B CG  1 
ATOM   6203 C  CD1 . PHE B 1 326 ? -87.846 -39.498 -63.313 1.00 65.79  ?  326 PHE B CD1 1 
ATOM   6204 C  CD2 . PHE B 1 326 ? -85.815 -40.694 -63.653 1.00 65.53  ?  326 PHE B CD2 1 
ATOM   6205 C  CE1 . PHE B 1 326 ? -87.620 -38.784 -64.480 1.00 66.94  ?  326 PHE B CE1 1 
ATOM   6206 C  CE2 . PHE B 1 326 ? -85.590 -39.979 -64.820 1.00 67.05  ?  326 PHE B CE2 1 
ATOM   6207 C  CZ  . PHE B 1 326 ? -86.492 -39.025 -65.230 1.00 67.19  ?  326 PHE B CZ  1 
ATOM   6208 N  N   . LEU B 1 327 ? -86.442 -44.113 -62.623 1.00 65.42  ?  327 LEU B N   1 
ATOM   6209 C  CA  . LEU B 1 327 ? -85.776 -45.022 -63.595 1.00 65.30  ?  327 LEU B CA  1 
ATOM   6210 C  C   . LEU B 1 327 ? -86.787 -46.068 -64.084 1.00 65.59  ?  327 LEU B C   1 
ATOM   6211 O  O   . LEU B 1 327 ? -86.730 -46.409 -65.281 1.00 67.70  ?  327 LEU B O   1 
ATOM   6212 C  CB  . LEU B 1 327 ? -84.548 -45.678 -62.953 1.00 66.33  ?  327 LEU B CB  1 
ATOM   6213 C  CG  . LEU B 1 327 ? -83.336 -44.764 -62.759 1.00 67.23  ?  327 LEU B CG  1 
ATOM   6214 C  CD1 . LEU B 1 327 ? -82.244 -45.468 -61.969 1.00 67.85  ?  327 LEU B CD1 1 
ATOM   6215 C  CD2 . LEU B 1 327 ? -82.786 -44.276 -64.090 1.00 68.58  ?  327 LEU B CD2 1 
ATOM   6216 N  N   . ARG B 1 328 ? -87.683 -46.534 -63.202 1.00 65.22  ?  328 ARG B N   1 
ATOM   6217 C  CA  . ARG B 1 328 ? -88.790 -47.474 -63.546 1.00 63.77  ?  328 ARG B CA  1 
ATOM   6218 C  C   . ARG B 1 328 ? -89.711 -46.820 -64.591 1.00 67.17  ?  328 ARG B C   1 
ATOM   6219 O  O   . ARG B 1 328 ? -90.118 -47.531 -65.530 1.00 70.81  ?  328 ARG B O   1 
ATOM   6220 C  CB  . ARG B 1 328 ? -89.559 -47.890 -62.288 1.00 58.64  ?  328 ARG B CB  1 
ATOM   6221 N  N   . LEU B 1 329 ? -90.014 -45.522 -64.451 1.00 69.94  ?  329 LEU B N   1 
ATOM   6222 C  CA  . LEU B 1 329 ? -90.830 -44.746 -65.430 1.00 71.86  ?  329 LEU B CA  1 
ATOM   6223 C  C   . LEU B 1 329 ? -90.102 -44.666 -66.775 1.00 74.42  ?  329 LEU B C   1 
ATOM   6224 O  O   . LEU B 1 329 ? -90.752 -44.923 -67.803 1.00 80.95  ?  329 LEU B O   1 
ATOM   6225 C  CB  . LEU B 1 329 ? -91.109 -43.334 -64.903 1.00 71.51  ?  329 LEU B CB  1 
ATOM   6226 C  CG  . LEU B 1 329 ? -92.109 -43.229 -63.754 1.00 73.65  ?  329 LEU B CG  1 
ATOM   6227 C  CD1 . LEU B 1 329 ? -92.267 -41.779 -63.322 1.00 73.80  ?  329 LEU B CD1 1 
ATOM   6228 C  CD2 . LEU B 1 329 ? -93.457 -43.818 -64.138 1.00 73.99  ?  329 LEU B CD2 1 
ATOM   6229 N  N   . ALA B 1 330 ? -88.814 -44.308 -66.760 1.00 74.95  ?  330 ALA B N   1 
ATOM   6230 C  CA  . ALA B 1 330 ? -87.965 -44.110 -67.962 1.00 75.75  ?  330 ALA B CA  1 
ATOM   6231 C  C   . ALA B 1 330 ? -87.989 -45.359 -68.855 1.00 79.34  ?  330 ALA B C   1 
ATOM   6232 O  O   . ALA B 1 330 ? -87.890 -45.202 -70.086 1.00 80.66  ?  330 ALA B O   1 
ATOM   6233 C  CB  . ALA B 1 330 ? -86.558 -43.760 -67.552 1.00 74.46  ?  330 ALA B CB  1 
ATOM   6234 N  N   . ALA B 1 331 ? -88.116 -46.546 -68.254 1.00 83.89  ?  331 ALA B N   1 
ATOM   6235 C  CA  . ALA B 1 331 ? -88.206 -47.850 -68.957 1.00 88.78  ?  331 ALA B CA  1 
ATOM   6236 C  C   . ALA B 1 331 ? -89.494 -47.929 -69.793 1.00 93.94  ?  331 ALA B C   1 
ATOM   6237 O  O   . ALA B 1 331 ? -89.460 -48.577 -70.855 1.00 98.33  ?  331 ALA B O   1 
ATOM   6238 C  CB  . ALA B 1 331 ? -88.131 -48.980 -67.959 1.00 87.91  ?  331 ALA B CB  1 
ATOM   6239 N  N   . HIS B 1 332 ? -90.579 -47.296 -69.332 1.00 97.90  ?  332 HIS B N   1 
ATOM   6240 C  CA  . HIS B 1 332 ? -91.949 -47.404 -69.910 1.00 100.80 ?  332 HIS B CA  1 
ATOM   6241 C  C   . HIS B 1 332 ? -92.258 -46.231 -70.852 1.00 99.27  ?  332 HIS B C   1 
ATOM   6242 O  O   . HIS B 1 332 ? -93.332 -46.264 -71.484 1.00 104.40 ?  332 HIS B O   1 
ATOM   6243 C  CB  . HIS B 1 332 ? -92.994 -47.516 -68.789 1.00 107.48 ?  332 HIS B CB  1 
ATOM   6244 C  CG  . HIS B 1 332 ? -92.880 -48.770 -67.988 1.00 114.57 ?  332 HIS B CG  1 
ATOM   6245 N  ND1 . HIS B 1 332 ? -92.893 -50.024 -68.573 1.00 117.98 ?  332 HIS B ND1 1 
ATOM   6246 C  CD2 . HIS B 1 332 ? -92.756 -48.973 -66.658 1.00 116.98 ?  332 HIS B CD2 1 
ATOM   6247 C  CE1 . HIS B 1 332 ? -92.776 -50.944 -67.638 1.00 120.19 ?  332 HIS B CE1 1 
ATOM   6248 N  NE2 . HIS B 1 332 ? -92.690 -50.325 -66.452 1.00 119.52 ?  332 HIS B NE2 1 
ATOM   6249 N  N   . ARG B 1 333 ? -91.370 -45.234 -70.939 1.00 95.11  ?  333 ARG B N   1 
ATOM   6250 C  CA  . ARG B 1 333 ? -91.504 -44.087 -71.881 1.00 93.25  ?  333 ARG B CA  1 
ATOM   6251 C  C   . ARG B 1 333 ? -90.452 -44.226 -72.988 1.00 93.52  ?  333 ARG B C   1 
ATOM   6252 O  O   . ARG B 1 333 ? -89.357 -44.753 -72.705 1.00 94.44  ?  333 ARG B O   1 
ATOM   6253 C  CB  . ARG B 1 333 ? -91.349 -42.758 -71.135 1.00 94.25  ?  333 ARG B CB  1 
ATOM   6254 C  CG  . ARG B 1 333 ? -92.552 -42.376 -70.285 1.00 95.84  ?  333 ARG B CG  1 
ATOM   6255 C  CD  . ARG B 1 333 ? -93.610 -41.612 -71.063 1.00 97.17  ?  333 ARG B CD  1 
ATOM   6256 N  NE  . ARG B 1 333 ? -93.461 -40.158 -70.985 1.00 95.71  ?  333 ARG B NE  1 
ATOM   6257 C  CZ  . ARG B 1 333 ? -94.106 -39.354 -70.134 1.00 92.98  ?  333 ARG B CZ  1 
ATOM   6258 N  NH1 . ARG B 1 333 ? -94.961 -39.841 -69.252 1.00 93.38  ?  333 ARG B NH1 1 
ATOM   6259 N  NH2 . ARG B 1 333 ? -93.892 -38.050 -70.168 1.00 89.41  ?  333 ARG B NH2 1 
ATOM   6260 N  N   . ALA B 1 334 ? -90.785 -43.780 -74.202 1.00 93.21  ?  334 ALA B N   1 
ATOM   6261 C  CA  . ALA B 1 334 ? -89.878 -43.755 -75.375 1.00 91.69  ?  334 ALA B CA  1 
ATOM   6262 C  C   . ALA B 1 334 ? -89.062 -42.460 -75.343 1.00 90.93  ?  334 ALA B C   1 
ATOM   6263 O  O   . ALA B 1 334 ? -87.820 -42.538 -75.385 1.00 92.04  ?  334 ALA B O   1 
ATOM   6264 C  CB  . ALA B 1 334 ? -90.670 -43.877 -76.653 1.00 90.60  ?  334 ALA B CB  1 
ATOM   6265 N  N   . ASN B 1 335 ? -89.754 -41.321 -75.254 1.00 90.60  ?  335 ASN B N   1 
ATOM   6266 C  CA  . ASN B 1 335 ? -89.154 -39.960 -75.269 1.00 91.30  ?  335 ASN B CA  1 
ATOM   6267 C  C   . ASN B 1 335 ? -88.791 -39.548 -73.836 1.00 89.75  ?  335 ASN B C   1 
ATOM   6268 O  O   . ASN B 1 335 ? -89.703 -39.143 -73.086 1.00 88.89  ?  335 ASN B O   1 
ATOM   6269 C  CB  . ASN B 1 335 ? -90.091 -38.950 -75.936 1.00 92.81  ?  335 ASN B CB  1 
ATOM   6270 C  CG  . ASN B 1 335 ? -89.439 -37.608 -76.192 1.00 96.80  ?  335 ASN B CG  1 
ATOM   6271 O  OD1 . ASN B 1 335 ? -88.215 -37.490 -76.191 1.00 100.60 ?  335 ASN B OD1 1 
ATOM   6272 N  ND2 . ASN B 1 335 ? -90.251 -36.589 -76.423 1.00 100.69 ?  335 ASN B ND2 1 
ATOM   6273 N  N   . LEU B 1 336 ? -87.504 -39.641 -73.487 1.00 87.99  ?  336 LEU B N   1 
ATOM   6274 C  CA  . LEU B 1 336 ? -86.958 -39.293 -72.144 1.00 86.93  ?  336 LEU B CA  1 
ATOM   6275 C  C   . LEU B 1 336 ? -87.094 -37.784 -71.895 1.00 81.41  ?  336 LEU B C   1 
ATOM   6276 O  O   . LEU B 1 336 ? -87.273 -37.395 -70.725 1.00 80.16  ?  336 LEU B O   1 
ATOM   6277 C  CB  . LEU B 1 336 ? -85.492 -39.735 -72.071 1.00 89.38  ?  336 LEU B CB  1 
ATOM   6278 C  CG  . LEU B 1 336 ? -84.772 -39.430 -70.757 1.00 93.20  ?  336 LEU B CG  1 
ATOM   6279 C  CD1 . LEU B 1 336 ? -85.247 -40.358 -69.649 1.00 93.87  ?  336 LEU B CD1 1 
ATOM   6280 C  CD2 . LEU B 1 336 ? -83.266 -39.532 -70.929 1.00 94.54  ?  336 LEU B CD2 1 
ATOM   6281 N  N   . GLU B 1 337 ? -87.003 -36.966 -72.947 1.00 77.97  ?  337 GLU B N   1 
ATOM   6282 C  CA  . GLU B 1 337 ? -87.089 -35.482 -72.851 1.00 80.24  ?  337 GLU B CA  1 
ATOM   6283 C  C   . GLU B 1 337 ? -88.485 -35.082 -72.355 1.00 77.97  ?  337 GLU B C   1 
ATOM   6284 O  O   . GLU B 1 337 ? -88.566 -34.223 -71.463 1.00 74.84  ?  337 GLU B O   1 
ATOM   6285 C  CB  . GLU B 1 337 ? -86.780 -34.830 -74.199 1.00 84.09  ?  337 GLU B CB  1 
ATOM   6286 C  CG  . GLU B 1 337 ? -86.644 -33.319 -74.120 1.00 87.18  ?  337 GLU B CG  1 
ATOM   6287 C  CD  . GLU B 1 337 ? -86.500 -32.629 -75.465 1.00 90.62  ?  337 GLU B CD  1 
ATOM   6288 O  OE1 . GLU B 1 337 ? -87.073 -31.531 -75.626 1.00 89.39  ?  337 GLU B OE1 1 
ATOM   6289 O  OE2 . GLU B 1 337 ? -85.816 -33.193 -76.348 1.00 93.53  -1 337 GLU B OE2 1 
ATOM   6290 N  N   . GLU B 1 338 ? -89.537 -35.679 -72.922 1.00 78.64  ?  338 GLU B N   1 
ATOM   6291 C  CA  . GLU B 1 338 ? -90.948 -35.470 -72.491 1.00 78.65  ?  338 GLU B CA  1 
ATOM   6292 C  C   . GLU B 1 338 ? -91.096 -35.820 -71.004 1.00 74.71  ?  338 GLU B C   1 
ATOM   6293 O  O   . GLU B 1 338 ? -91.738 -35.034 -70.278 1.00 74.86  ?  338 GLU B O   1 
ATOM   6294 C  CB  . GLU B 1 338 ? -91.914 -36.315 -73.324 1.00 84.77  ?  338 GLU B CB  1 
ATOM   6295 C  CG  . GLU B 1 338 ? -92.645 -35.528 -74.397 1.00 87.39  ?  338 GLU B CG  1 
ATOM   6296 C  CD  . GLU B 1 338 ? -93.722 -36.319 -75.120 1.00 89.31  ?  338 GLU B CD  1 
ATOM   6297 O  OE1 . GLU B 1 338 ? -94.089 -35.916 -76.242 1.00 91.97  ?  338 GLU B OE1 1 
ATOM   6298 O  OE2 . GLU B 1 338 ? -94.195 -37.334 -74.557 1.00 86.91  -1 338 GLU B OE2 1 
ATOM   6299 N  N   . LEU B 1 339 ? -90.534 -36.957 -70.579 1.00 69.65  ?  339 LEU B N   1 
ATOM   6300 C  CA  . LEU B 1 339 ? -90.605 -37.447 -69.173 1.00 68.10  ?  339 LEU B CA  1 
ATOM   6301 C  C   . LEU B 1 339 ? -89.926 -36.441 -68.234 1.00 67.25  ?  339 LEU B C   1 
ATOM   6302 O  O   . LEU B 1 339 ? -90.460 -36.216 -67.131 1.00 67.15  ?  339 LEU B O   1 
ATOM   6303 C  CB  . LEU B 1 339 ? -89.950 -38.829 -69.067 1.00 67.70  ?  339 LEU B CB  1 
ATOM   6304 C  CG  . LEU B 1 339 ? -89.886 -39.424 -67.660 1.00 67.65  ?  339 LEU B CG  1 
ATOM   6305 C  CD1 . LEU B 1 339 ? -91.268 -39.498 -67.027 1.00 68.18  ?  339 LEU B CD1 1 
ATOM   6306 C  CD2 . LEU B 1 339 ? -89.244 -40.802 -67.683 1.00 68.57  ?  339 LEU B CD2 1 
ATOM   6307 N  N   . LEU B 1 340 ? -88.792 -35.865 -68.647 1.00 64.28  ?  340 LEU B N   1 
ATOM   6308 C  CA  . LEU B 1 340 ? -88.050 -34.862 -67.836 1.00 62.87  ?  340 LEU B CA  1 
ATOM   6309 C  C   . LEU B 1 340 ? -88.876 -33.576 -67.749 1.00 59.20  ?  340 LEU B C   1 
ATOM   6310 O  O   . LEU B 1 340 ? -88.980 -33.019 -66.641 1.00 59.17  ?  340 LEU B O   1 
ATOM   6311 C  CB  . LEU B 1 340 ? -86.671 -34.606 -68.452 1.00 64.21  ?  340 LEU B CB  1 
ATOM   6312 C  CG  . LEU B 1 340 ? -85.634 -35.704 -68.215 1.00 66.23  ?  340 LEU B CG  1 
ATOM   6313 C  CD1 . LEU B 1 340 ? -84.414 -35.496 -69.098 1.00 66.98  ?  340 LEU B CD1 1 
ATOM   6314 C  CD2 . LEU B 1 340 ? -85.230 -35.769 -66.749 1.00 66.43  ?  340 LEU B CD2 1 
ATOM   6315 N  N   . VAL B 1 341 ? -89.463 -33.146 -68.868 1.00 56.38  ?  341 VAL B N   1 
ATOM   6316 C  CA  . VAL B 1 341 ? -90.316 -31.923 -68.948 1.00 56.55  ?  341 VAL B CA  1 
ATOM   6317 C  C   . VAL B 1 341 ? -91.535 -32.098 -68.032 1.00 55.58  ?  341 VAL B C   1 
ATOM   6318 O  O   . VAL B 1 341 ? -91.970 -31.093 -67.451 1.00 55.99  ?  341 VAL B O   1 
ATOM   6319 C  CB  . VAL B 1 341 ? -90.729 -31.611 -70.400 1.00 58.68  ?  341 VAL B CB  1 
ATOM   6320 C  CG1 . VAL B 1 341 ? -91.785 -30.519 -70.471 1.00 59.73  ?  341 VAL B CG1 1 
ATOM   6321 C  CG2 . VAL B 1 341 ? -89.530 -31.232 -71.257 1.00 59.50  ?  341 VAL B CG2 1 
ATOM   6322 N  N   . ASP B 1 342 ? -92.057 -33.320 -67.892 1.00 56.94  ?  342 ASP B N   1 
ATOM   6323 C  CA  . ASP B 1 342 ? -93.283 -33.604 -67.094 1.00 58.16  ?  342 ASP B CA  1 
ATOM   6324 C  C   . ASP B 1 342 ? -92.939 -33.801 -65.613 1.00 59.62  ?  342 ASP B C   1 
ATOM   6325 O  O   . ASP B 1 342 ? -93.837 -33.570 -64.778 1.00 61.28  ?  342 ASP B O   1 
ATOM   6326 C  CB  . ASP B 1 342 ? -94.023 -34.835 -67.621 1.00 59.10  ?  342 ASP B CB  1 
ATOM   6327 C  CG  . ASP B 1 342 ? -94.711 -34.630 -68.960 1.00 58.35  ?  342 ASP B CG  1 
ATOM   6328 O  OD1 . ASP B 1 342 ? -94.991 -33.463 -69.309 1.00 60.20  ?  342 ASP B OD1 1 
ATOM   6329 O  OD2 . ASP B 1 342 ? -94.962 -35.642 -69.646 1.00 56.39  -1 342 ASP B OD2 1 
ATOM   6330 N  N   . SER B 1 343 ? -91.703 -34.214 -65.304 1.00 61.69  ?  343 SER B N   1 
ATOM   6331 C  CA  . SER B 1 343 ? -91.299 -34.758 -63.974 1.00 60.92  ?  343 SER B CA  1 
ATOM   6332 C  C   . SER B 1 343 ? -90.360 -33.829 -63.187 1.00 58.80  ?  343 SER B C   1 
ATOM   6333 O  O   . SER B 1 343 ? -90.279 -34.012 -61.959 1.00 58.53  ?  343 SER B O   1 
ATOM   6334 C  CB  . SER B 1 343 ? -90.658 -36.110 -64.141 1.00 62.64  ?  343 SER B CB  1 
ATOM   6335 O  OG  . SER B 1 343 ? -91.505 -36.987 -64.865 1.00 65.46  ?  343 SER B OG  1 
ATOM   6336 N  N   . PHE B 1 344 ? -89.660 -32.894 -63.838 1.00 56.72  ?  344 PHE B N   1 
ATOM   6337 C  CA  . PHE B 1 344 ? -88.464 -32.215 -63.263 1.00 55.19  ?  344 PHE B CA  1 
ATOM   6338 C  C   . PHE B 1 344 ? -88.783 -31.585 -61.898 1.00 55.92  ?  344 PHE B C   1 
ATOM   6339 O  O   . PHE B 1 344 ? -87.870 -31.527 -61.057 1.00 59.20  ?  344 PHE B O   1 
ATOM   6340 C  CB  . PHE B 1 344 ? -87.880 -31.190 -64.234 1.00 54.56  ?  344 PHE B CB  1 
ATOM   6341 C  CG  . PHE B 1 344 ? -88.651 -29.903 -64.351 1.00 56.57  ?  344 PHE B CG  1 
ATOM   6342 C  CD1 . PHE B 1 344 ? -88.388 -28.840 -63.502 1.00 57.13  ?  344 PHE B CD1 1 
ATOM   6343 C  CD2 . PHE B 1 344 ? -89.620 -29.746 -65.330 1.00 57.84  ?  344 PHE B CD2 1 
ATOM   6344 C  CE1 . PHE B 1 344 ? -89.095 -27.654 -63.612 1.00 57.61  ?  344 PHE B CE1 1 
ATOM   6345 C  CE2 . PHE B 1 344 ? -90.322 -28.557 -65.443 1.00 57.41  ?  344 PHE B CE2 1 
ATOM   6346 C  CZ  . PHE B 1 344 ? -90.061 -27.515 -64.582 1.00 58.67  ?  344 PHE B CZ  1 
ATOM   6347 N  N   . GLN B 1 345 ? -90.020 -31.132 -61.671 1.00 54.26  ?  345 GLN B N   1 
ATOM   6348 C  CA  . GLN B 1 345 ? -90.430 -30.542 -60.366 1.00 53.59  ?  345 GLN B CA  1 
ATOM   6349 C  C   . GLN B 1 345 ? -90.287 -31.593 -59.255 1.00 52.14  ?  345 GLN B C   1 
ATOM   6350 O  O   . GLN B 1 345 ? -90.022 -31.190 -58.112 1.00 53.33  ?  345 GLN B O   1 
ATOM   6351 C  CB  . GLN B 1 345 ? -91.847 -29.956 -60.410 1.00 54.18  ?  345 GLN B CB  1 
ATOM   6352 C  CG  . GLN B 1 345 ? -92.963 -30.983 -60.573 1.00 53.51  ?  345 GLN B CG  1 
ATOM   6353 C  CD  . GLN B 1 345 ? -93.221 -31.333 -62.018 1.00 54.02  ?  345 GLN B CD  1 
ATOM   6354 O  OE1 . GLN B 1 345 ? -92.859 -30.591 -62.930 1.00 55.57  ?  345 GLN B OE1 1 
ATOM   6355 N  NE2 . GLN B 1 345 ? -93.851 -32.475 -62.240 1.00 54.06  ?  345 GLN B NE2 1 
ATOM   6356 N  N   . ASP B 1 346 ? -90.450 -32.882 -59.570 1.00 51.71  ?  346 ASP B N   1 
ATOM   6357 C  CA  . ASP B 1 346 ? -90.435 -33.983 -58.567 1.00 52.70  ?  346 ASP B CA  1 
ATOM   6358 C  C   . ASP B 1 346 ? -89.044 -34.091 -57.926 1.00 54.18  ?  346 ASP B C   1 
ATOM   6359 O  O   . ASP B 1 346 ? -88.976 -34.521 -56.758 1.00 53.44  ?  346 ASP B O   1 
ATOM   6360 C  CB  . ASP B 1 346 ? -90.870 -35.318 -59.177 1.00 51.71  ?  346 ASP B CB  1 
ATOM   6361 C  CG  . ASP B 1 346 ? -92.313 -35.343 -59.660 1.00 52.91  ?  346 ASP B CG  1 
ATOM   6362 O  OD1 . ASP B 1 346 ? -93.029 -34.342 -59.439 1.00 50.30  ?  346 ASP B OD1 1 
ATOM   6363 O  OD2 . ASP B 1 346 ? -92.710 -36.370 -60.260 1.00 56.32  -1 346 ASP B OD2 1 
ATOM   6364 N  N   . PHE B 1 347 ? -87.986 -33.701 -58.647 1.00 56.75  ?  347 PHE B N   1 
ATOM   6365 C  CA  . PHE B 1 347 ? -86.574 -33.762 -58.178 1.00 57.09  ?  347 PHE B CA  1 
ATOM   6366 C  C   . PHE B 1 347 ? -86.325 -32.732 -57.070 1.00 57.22  ?  347 PHE B C   1 
ATOM   6367 O  O   . PHE B 1 347 ? -85.307 -32.867 -56.372 1.00 59.72  ?  347 PHE B O   1 
ATOM   6368 C  CB  . PHE B 1 347 ? -85.594 -33.577 -59.339 1.00 58.65  ?  347 PHE B CB  1 
ATOM   6369 C  CG  . PHE B 1 347 ? -85.572 -34.727 -60.315 1.00 61.43  ?  347 PHE B CG  1 
ATOM   6370 C  CD1 . PHE B 1 347 ? -85.325 -36.020 -59.883 1.00 62.37  ?  347 PHE B CD1 1 
ATOM   6371 C  CD2 . PHE B 1 347 ? -85.800 -34.518 -61.667 1.00 63.27  ?  347 PHE B CD2 1 
ATOM   6372 C  CE1 . PHE B 1 347 ? -85.313 -37.078 -60.780 1.00 64.37  ?  347 PHE B CE1 1 
ATOM   6373 C  CE2 . PHE B 1 347 ? -85.782 -35.576 -62.563 1.00 63.51  ?  347 PHE B CE2 1 
ATOM   6374 C  CZ  . PHE B 1 347 ? -85.540 -36.854 -62.118 1.00 63.45  ?  347 PHE B CZ  1 
ATOM   6375 N  N   . ALA B 1 348 ? -87.227 -31.762 -56.890 1.00 58.62  ?  348 ALA B N   1 
ATOM   6376 C  CA  . ALA B 1 348 ? -87.202 -30.783 -55.773 1.00 59.64  ?  348 ALA B CA  1 
ATOM   6377 C  C   . ALA B 1 348 ? -87.426 -31.495 -54.433 1.00 60.94  ?  348 ALA B C   1 
ATOM   6378 O  O   . ALA B 1 348 ? -87.236 -30.844 -53.394 1.00 64.25  ?  348 ALA B O   1 
ATOM   6379 C  CB  . ALA B 1 348 ? -88.234 -29.704 -55.987 1.00 58.50  ?  348 ALA B CB  1 
ATOM   6380 N  N   . ARG B 1 349 ? -87.830 -32.769 -54.460 1.00 65.48  ?  349 ARG B N   1 
ATOM   6381 C  CA  . ARG B 1 349 ? -88.008 -33.611 -53.238 1.00 70.02  ?  349 ARG B CA  1 
ATOM   6382 C  C   . ARG B 1 349 ? -86.667 -34.232 -52.807 1.00 67.90  ?  349 ARG B C   1 
ATOM   6383 O  O   . ARG B 1 349 ? -86.570 -34.635 -51.635 1.00 68.13  ?  349 ARG B O   1 
ATOM   6384 C  CB  . ARG B 1 349 ? -89.048 -34.711 -53.480 1.00 75.50  ?  349 ARG B CB  1 
ATOM   6385 C  CG  . ARG B 1 349 ? -90.444 -34.205 -53.824 1.00 81.45  ?  349 ARG B CG  1 
ATOM   6386 C  CD  . ARG B 1 349 ? -91.537 -35.179 -53.411 1.00 88.82  ?  349 ARG B CD  1 
ATOM   6387 N  NE  . ARG B 1 349 ? -92.634 -35.281 -54.373 1.00 93.40  ?  349 ARG B NE  1 
ATOM   6388 C  CZ  . ARG B 1 349 ? -92.729 -36.191 -55.348 1.00 97.81  ?  349 ARG B CZ  1 
ATOM   6389 N  NH1 . ARG B 1 349 ? -91.782 -37.100 -55.526 1.00 99.62  ?  349 ARG B NH1 1 
ATOM   6390 N  NH2 . ARG B 1 349 ? -93.779 -36.186 -56.153 1.00 96.50  ?  349 ARG B NH2 1 
ATOM   6391 N  N   . LEU B 1 350 ? -85.681 -34.323 -53.709 1.00 65.32  ?  350 LEU B N   1 
ATOM   6392 C  CA  . LEU B 1 350 ? -84.349 -34.935 -53.433 1.00 63.28  ?  350 LEU B CA  1 
ATOM   6393 C  C   . LEU B 1 350 ? -83.483 -33.970 -52.627 1.00 60.41  ?  350 LEU B C   1 
ATOM   6394 O  O   . LEU B 1 350 ? -82.781 -34.435 -51.718 1.00 64.84  ?  350 LEU B O   1 
ATOM   6395 C  CB  . LEU B 1 350 ? -83.634 -35.269 -54.746 1.00 65.01  ?  350 LEU B CB  1 
ATOM   6396 C  CG  . LEU B 1 350 ? -84.370 -36.200 -55.706 1.00 66.23  ?  350 LEU B CG  1 
ATOM   6397 C  CD1 . LEU B 1 350 ? -83.404 -36.767 -56.735 1.00 65.92  ?  350 LEU B CD1 1 
ATOM   6398 C  CD2 . LEU B 1 350 ? -85.080 -37.322 -54.965 1.00 65.54  ?  350 LEU B CD2 1 
ATOM   6399 N  N   . ILE B 1 351 ? -83.503 -32.689 -52.995 1.00 60.79  ?  351 ILE B N   1 
ATOM   6400 C  CA  . ILE B 1 351 ? -82.578 -31.639 -52.472 1.00 60.96  ?  351 ILE B CA  1 
ATOM   6401 C  C   . ILE B 1 351 ? -83.410 -30.434 -52.049 1.00 59.09  ?  351 ILE B C   1 
ATOM   6402 O  O   . ILE B 1 351 ? -84.165 -29.904 -52.861 1.00 62.50  ?  351 ILE B O   1 
ATOM   6403 C  CB  . ILE B 1 351 ? -81.530 -31.254 -53.538 1.00 62.00  ?  351 ILE B CB  1 
ATOM   6404 C  CG1 . ILE B 1 351 ? -80.822 -32.480 -54.123 1.00 64.02  ?  351 ILE B CG1 1 
ATOM   6405 C  CG2 . ILE B 1 351 ? -80.536 -30.251 -52.975 1.00 61.96  ?  351 ILE B CG2 1 
ATOM   6406 C  CD1 . ILE B 1 351 ? -79.993 -32.185 -55.356 1.00 65.27  ?  351 ILE B CD1 1 
ATOM   6407 N  N   . PRO B 1 352 ? -83.303 -29.954 -50.787 1.00 59.15  ?  352 PRO B N   1 
ATOM   6408 C  CA  . PRO B 1 352 ? -84.008 -28.744 -50.370 1.00 57.70  ?  352 PRO B CA  1 
ATOM   6409 C  C   . PRO B 1 352 ? -83.638 -27.581 -51.299 1.00 56.87  ?  352 PRO B C   1 
ATOM   6410 O  O   . PRO B 1 352 ? -82.472 -27.243 -51.381 1.00 56.10  ?  352 PRO B O   1 
ATOM   6411 C  CB  . PRO B 1 352 ? -83.536 -28.484 -48.933 1.00 56.62  ?  352 PRO B CB  1 
ATOM   6412 C  CG  . PRO B 1 352 ? -83.031 -29.827 -48.456 1.00 58.78  ?  352 PRO B CG  1 
ATOM   6413 C  CD  . PRO B 1 352 ? -82.506 -30.530 -49.694 1.00 60.65  ?  352 PRO B CD  1 
ATOM   6414 N  N   . CYS B 1 353 ? -84.635 -27.044 -52.004 1.00 57.11  ?  353 CYS B N   1 
ATOM   6415 C  CA  . CYS B 1 353 ? -84.492 -25.900 -52.940 1.00 58.55  ?  353 CYS B CA  1 
ATOM   6416 C  C   . CYS B 1 353 ? -85.767 -25.056 -52.918 1.00 58.85  ?  353 CYS B C   1 
ATOM   6417 O  O   . CYS B 1 353 ? -86.819 -25.592 -52.537 1.00 61.67  ?  353 CYS B O   1 
ATOM   6418 C  CB  . CYS B 1 353 ? -84.219 -26.391 -54.355 1.00 59.06  ?  353 CYS B CB  1 
ATOM   6419 S  SG  . CYS B 1 353 ? -85.445 -27.588 -54.931 1.00 59.95  ?  353 CYS B SG  1 
ATOM   6420 N  N   . ASP B 1 354 ? -85.656 -23.784 -53.304 1.00 58.70  ?  354 ASP B N   1 
ATOM   6421 C  CA  . ASP B 1 354 ? -86.789 -22.825 -53.404 1.00 56.16  ?  354 ASP B CA  1 
ATOM   6422 C  C   . ASP B 1 354 ? -87.348 -22.856 -54.832 1.00 55.77  ?  354 ASP B C   1 
ATOM   6423 O  O   . ASP B 1 354 ? -88.441 -22.296 -55.061 1.00 56.92  ?  354 ASP B O   1 
ATOM   6424 C  CB  . ASP B 1 354 ? -86.330 -21.432 -52.980 1.00 56.43  ?  354 ASP B CB  1 
ATOM   6425 C  CG  . ASP B 1 354 ? -85.910 -21.376 -51.523 1.00 58.39  ?  354 ASP B CG  1 
ATOM   6426 O  OD1 . ASP B 1 354 ? -86.738 -21.741 -50.665 1.00 58.44  ?  354 ASP B OD1 1 
ATOM   6427 O  OD2 . ASP B 1 354 ? -84.750 -20.992 -51.258 1.00 61.51  -1 354 ASP B OD2 1 
ATOM   6428 N  N   . GLY B 1 355 ? -86.620 -23.490 -55.753 1.00 52.87  ?  355 GLY B N   1 
ATOM   6429 C  CA  . GLY B 1 355 ? -87.018 -23.640 -57.163 1.00 52.82  ?  355 GLY B CA  1 
ATOM   6430 C  C   . GLY B 1 355 ? -86.098 -24.597 -57.893 1.00 54.89  ?  355 GLY B C   1 
ATOM   6431 O  O   . GLY B 1 355 ? -84.951 -24.790 -57.438 1.00 57.57  ?  355 GLY B O   1 
ATOM   6432 N  N   . VAL B 1 356 ? -86.587 -25.191 -58.980 1.00 54.67  ?  356 VAL B N   1 
ATOM   6433 C  CA  . VAL B 1 356 ? -85.830 -26.180 -59.799 1.00 54.93  ?  356 VAL B CA  1 
ATOM   6434 C  C   . VAL B 1 356 ? -86.145 -25.913 -61.272 1.00 55.11  ?  356 VAL B C   1 
ATOM   6435 O  O   . VAL B 1 356 ? -87.260 -25.453 -61.569 1.00 54.98  ?  356 VAL B O   1 
ATOM   6436 C  CB  . VAL B 1 356 ? -86.158 -27.627 -59.382 1.00 56.86  ?  356 VAL B CB  1 
ATOM   6437 C  CG1 . VAL B 1 356 ? -87.655 -27.894 -59.387 1.00 57.93  ?  356 VAL B CG1 1 
ATOM   6438 C  CG2 . VAL B 1 356 ? -85.427 -28.652 -60.239 1.00 57.95  ?  356 VAL B CG2 1 
ATOM   6439 N  N   . GLY B 1 357 ? -85.184 -26.189 -62.152 1.00 55.57  ?  357 GLY B N   1 
ATOM   6440 C  CA  . GLY B 1 357 ? -85.305 -25.913 -63.592 1.00 57.26  ?  357 GLY B CA  1 
ATOM   6441 C  C   . GLY B 1 357 ? -84.674 -26.999 -64.435 1.00 59.06  ?  357 GLY B C   1 
ATOM   6442 O  O   . GLY B 1 357 ? -83.786 -27.715 -63.927 1.00 60.21  ?  357 GLY B O   1 
ATOM   6443 N  N   . LEU B 1 358 ? -85.139 -27.112 -65.679 1.00 60.66  ?  358 LEU B N   1 
ATOM   6444 C  CA  . LEU B 1 358 ? -84.646 -28.075 -66.693 1.00 61.15  ?  358 LEU B CA  1 
ATOM   6445 C  C   . LEU B 1 358 ? -84.203 -27.277 -67.920 1.00 65.01  ?  358 LEU B C   1 
ATOM   6446 O  O   . LEU B 1 358 ? -85.051 -26.570 -68.502 1.00 66.27  ?  358 LEU B O   1 
ATOM   6447 C  CB  . LEU B 1 358 ? -85.770 -29.055 -67.038 1.00 60.17  ?  358 LEU B CB  1 
ATOM   6448 C  CG  . LEU B 1 358 ? -85.396 -30.172 -68.008 1.00 61.73  ?  358 LEU B CG  1 
ATOM   6449 C  CD1 . LEU B 1 358 ? -84.407 -31.136 -67.371 1.00 61.90  ?  358 LEU B CD1 1 
ATOM   6450 C  CD2 . LEU B 1 358 ? -86.638 -30.913 -68.482 1.00 62.27  ?  358 LEU B CD2 1 
ATOM   6451 N  N   . TRP B 1 359 ? -82.913 -27.354 -68.248 1.00 67.97  ?  359 TRP B N   1 
ATOM   6452 C  CA  . TRP B 1 359 ? -82.318 -26.830 -69.504 1.00 69.01  ?  359 TRP B CA  1 
ATOM   6453 C  C   . TRP B 1 359 ? -82.002 -28.024 -70.407 1.00 72.56  ?  359 TRP B C   1 
ATOM   6454 O  O   . TRP B 1 359 ? -80.994 -28.701 -70.146 1.00 74.99  ?  359 TRP B O   1 
ATOM   6455 C  CB  . TRP B 1 359 ? -81.079 -25.983 -69.197 1.00 70.24  ?  359 TRP B CB  1 
ATOM   6456 C  CG  . TRP B 1 359 ? -80.412 -25.412 -70.408 1.00 73.93  ?  359 TRP B CG  1 
ATOM   6457 C  CD1 . TRP B 1 359 ? -79.289 -25.879 -71.026 1.00 77.04  ?  359 TRP B CD1 1 
ATOM   6458 C  CD2 . TRP B 1 359 ? -80.830 -24.258 -71.158 1.00 76.65  ?  359 TRP B CD2 1 
ATOM   6459 N  NE1 . TRP B 1 359 ? -78.978 -25.097 -72.106 1.00 78.73  ?  359 TRP B NE1 1 
ATOM   6460 C  CE2 . TRP B 1 359 ? -79.905 -24.094 -72.211 1.00 78.81  ?  359 TRP B CE2 1 
ATOM   6461 C  CE3 . TRP B 1 359 ? -81.893 -23.353 -71.046 1.00 77.15  ?  359 TRP B CE3 1 
ATOM   6462 C  CZ2 . TRP B 1 359 ? -80.015 -23.060 -73.141 1.00 80.08  ?  359 TRP B CZ2 1 
ATOM   6463 C  CZ3 . TRP B 1 359 ? -82.000 -22.332 -71.965 1.00 77.62  ?  359 TRP B CZ3 1 
ATOM   6464 C  CH2 . TRP B 1 359 ? -81.072 -22.191 -72.998 1.00 79.54  ?  359 TRP B CH2 1 
ATOM   6465 N  N   . VAL B 1 360 ? -82.867 -28.295 -71.389 1.00 78.40  ?  360 VAL B N   1 
ATOM   6466 C  CA  . VAL B 1 360 ? -82.752 -29.450 -72.331 1.00 83.08  ?  360 VAL B CA  1 
ATOM   6467 C  C   . VAL B 1 360 ? -83.048 -28.950 -73.750 1.00 84.07  ?  360 VAL B C   1 
ATOM   6468 O  O   . VAL B 1 360 ? -84.071 -28.258 -73.930 1.00 84.48  ?  360 VAL B O   1 
ATOM   6469 C  CB  . VAL B 1 360 ? -83.676 -30.616 -71.919 1.00 87.27  ?  360 VAL B CB  1 
ATOM   6470 C  CG1 . VAL B 1 360 ? -85.146 -30.222 -71.914 1.00 89.84  ?  360 VAL B CG1 1 
ATOM   6471 C  CG2 . VAL B 1 360 ? -83.456 -31.846 -72.788 1.00 90.17  ?  360 VAL B CG2 1 
ATOM   6472 N  N   . GLY B 1 361 ? -82.170 -29.276 -74.706 1.00 85.03  ?  361 GLY B N   1 
ATOM   6473 C  CA  . GLY B 1 361 ? -82.263 -28.837 -76.113 1.00 86.00  ?  361 GLY B CA  1 
ATOM   6474 C  C   . GLY B 1 361 ? -82.442 -27.332 -76.227 1.00 87.66  ?  361 GLY B C   1 
ATOM   6475 O  O   . GLY B 1 361 ? -83.250 -26.899 -77.070 1.00 94.00  ?  361 GLY B O   1 
ATOM   6476 N  N   . ASN B 1 362 ? -81.737 -26.568 -75.386 1.00 88.94  ?  362 ASN B N   1 
ATOM   6477 C  CA  . ASN B 1 362 ? -81.730 -25.079 -75.372 1.00 92.14  ?  362 ASN B CA  1 
ATOM   6478 C  C   . ASN B 1 362 ? -83.140 -24.537 -75.095 1.00 87.63  ?  362 ASN B C   1 
ATOM   6479 O  O   . ASN B 1 362 ? -83.406 -23.382 -75.476 1.00 86.71  ?  362 ASN B O   1 
ATOM   6480 C  CB  . ASN B 1 362 ? -81.159 -24.500 -76.671 1.00 97.89  ?  362 ASN B CB  1 
ATOM   6481 C  CG  . ASN B 1 362 ? -79.715 -24.891 -76.904 1.00 102.61 ?  362 ASN B CG  1 
ATOM   6482 O  OD1 . ASN B 1 362 ? -79.402 -26.071 -77.042 1.00 104.91 ?  362 ASN B OD1 1 
ATOM   6483 N  ND2 . ASN B 1 362 ? -78.827 -23.909 -76.955 1.00 105.67 ?  362 ASN B ND2 1 
ATOM   6484 N  N   . ASN B 1 363 ? -83.994 -25.330 -74.439 1.00 84.00  ?  363 ASN B N   1 
ATOM   6485 C  CA  . ASN B 1 363 ? -85.351 -24.924 -73.980 1.00 82.10  ?  363 ASN B CA  1 
ATOM   6486 C  C   . ASN B 1 363 ? -85.374 -24.965 -72.450 1.00 76.06  ?  363 ASN B C   1 
ATOM   6487 O  O   . ASN B 1 363 ? -84.883 -25.960 -71.884 1.00 76.91  ?  363 ASN B O   1 
ATOM   6488 C  CB  . ASN B 1 363 ? -86.450 -25.817 -74.563 1.00 87.48  ?  363 ASN B CB  1 
ATOM   6489 C  CG  . ASN B 1 363 ? -86.678 -25.594 -76.043 1.00 94.12  ?  363 ASN B CG  1 
ATOM   6490 O  OD1 . ASN B 1 363 ? -86.532 -26.517 -76.844 1.00 95.93  ?  363 ASN B OD1 1 
ATOM   6491 N  ND2 . ASN B 1 363 ? -87.036 -24.375 -76.418 1.00 98.78  ?  363 ASN B ND2 1 
ATOM   6492 N  N   . TRP B 1 364 ? -85.934 -23.928 -71.821 1.00 69.95  ?  364 TRP B N   1 
ATOM   6493 C  CA  . TRP B 1 364 ? -85.994 -23.754 -70.343 1.00 67.35  ?  364 TRP B CA  1 
ATOM   6494 C  C   . TRP B 1 364 ? -87.394 -24.086 -69.817 1.00 68.57  ?  364 TRP B C   1 
ATOM   6495 O  O   . TRP B 1 364 ? -88.384 -23.674 -70.454 1.00 69.71  ?  364 TRP B O   1 
ATOM   6496 C  CB  . TRP B 1 364 ? -85.586 -22.328 -69.963 1.00 65.84  ?  364 TRP B CB  1 
ATOM   6497 C  CG  . TRP B 1 364 ? -85.888 -21.951 -68.546 1.00 65.13  ?  364 TRP B CG  1 
ATOM   6498 C  CD1 . TRP B 1 364 ? -86.837 -21.071 -68.115 1.00 66.10  ?  364 TRP B CD1 1 
ATOM   6499 C  CD2 . TRP B 1 364 ? -85.222 -22.429 -67.365 1.00 66.75  ?  364 TRP B CD2 1 
ATOM   6500 N  NE1 . TRP B 1 364 ? -86.808 -20.967 -66.751 1.00 65.81  ?  364 TRP B NE1 1 
ATOM   6501 C  CE2 . TRP B 1 364 ? -85.830 -21.791 -66.263 1.00 66.38  ?  364 TRP B CE2 1 
ATOM   6502 C  CE3 . TRP B 1 364 ? -84.176 -23.329 -67.131 1.00 67.22  ?  364 TRP B CE3 1 
ATOM   6503 C  CZ2 . TRP B 1 364 ? -85.424 -22.026 -64.951 1.00 68.03  ?  364 TRP B CZ2 1 
ATOM   6504 C  CZ3 . TRP B 1 364 ? -83.774 -23.559 -65.833 1.00 67.37  ?  364 TRP B CZ3 1 
ATOM   6505 C  CH2 . TRP B 1 364 ? -84.388 -22.911 -64.761 1.00 66.92  ?  364 TRP B CH2 1 
ATOM   6506 N  N   . HIS B 1 365 ? -87.457 -24.798 -68.688 1.00 67.77  ?  365 HIS B N   1 
ATOM   6507 C  CA  . HIS B 1 365 ? -88.697 -25.083 -67.916 1.00 66.01  ?  365 HIS B CA  1 
ATOM   6508 C  C   . HIS B 1 365 ? -88.407 -24.880 -66.427 1.00 64.54  ?  365 HIS B C   1 
ATOM   6509 O  O   . HIS B 1 365 ? -87.628 -25.674 -65.870 1.00 68.21  ?  365 HIS B O   1 
ATOM   6510 C  CB  . HIS B 1 365 ? -89.213 -26.498 -68.204 1.00 67.63  ?  365 HIS B CB  1 
ATOM   6511 C  CG  . HIS B 1 365 ? -89.406 -26.800 -69.652 1.00 70.27  ?  365 HIS B CG  1 
ATOM   6512 N  ND1 . HIS B 1 365 ? -90.577 -26.500 -70.317 1.00 70.94  ?  365 HIS B ND1 1 
ATOM   6513 C  CD2 . HIS B 1 365 ? -88.592 -27.389 -70.557 1.00 73.51  ?  365 HIS B CD2 1 
ATOM   6514 C  CE1 . HIS B 1 365 ? -90.475 -26.885 -71.574 1.00 75.82  ?  365 HIS B CE1 1 
ATOM   6515 N  NE2 . HIS B 1 365 ? -89.266 -27.438 -71.747 1.00 74.18  ?  365 HIS B NE2 1 
ATOM   6516 N  N   . GLY B 1 366 ? -89.011 -23.855 -65.818 1.00 62.53  ?  366 GLY B N   1 
ATOM   6517 C  CA  . GLY B 1 366 ? -88.806 -23.486 -64.404 1.00 61.83  ?  366 GLY B CA  1 
ATOM   6518 C  C   . GLY B 1 366 ? -89.951 -23.934 -63.509 1.00 61.35  ?  366 GLY B C   1 
ATOM   6519 O  O   . GLY B 1 366 ? -91.066 -24.156 -64.018 1.00 63.45  ?  366 GLY B O   1 
ATOM   6520 N  N   . HIS B 1 367 ? -89.670 -24.069 -62.212 1.00 60.50  ?  367 HIS B N   1 
ATOM   6521 C  CA  . HIS B 1 367 ? -90.657 -24.335 -61.133 1.00 60.29  ?  367 HIS B CA  1 
ATOM   6522 C  C   . HIS B 1 367 ? -90.162 -23.673 -59.846 1.00 59.35  ?  367 HIS B C   1 
ATOM   6523 O  O   . HIS B 1 367 ? -88.957 -23.770 -59.578 1.00 61.84  ?  367 HIS B O   1 
ATOM   6524 C  CB  . HIS B 1 367 ? -90.874 -25.843 -60.955 1.00 62.35  ?  367 HIS B CB  1 
ATOM   6525 C  CG  . HIS B 1 367 ? -91.906 -26.177 -59.931 1.00 64.18  ?  367 HIS B CG  1 
ATOM   6526 N  ND1 . HIS B 1 367 ? -93.261 -26.035 -60.174 1.00 64.05  ?  367 HIS B ND1 1 
ATOM   6527 C  CD2 . HIS B 1 367 ? -91.792 -26.636 -58.665 1.00 64.81  ?  367 HIS B CD2 1 
ATOM   6528 C  CE1 . HIS B 1 367 ? -93.935 -26.392 -59.100 1.00 66.35  ?  367 HIS B CE1 1 
ATOM   6529 N  NE2 . HIS B 1 367 ? -93.057 -26.769 -58.161 1.00 65.68  ?  367 HIS B NE2 1 
ATOM   6530 N  N   . GLY B 1 368 ? -91.061 -23.028 -59.096 1.00 59.44  ?  368 GLY B N   1 
ATOM   6531 C  CA  . GLY B 1 368 ? -90.732 -22.269 -57.873 1.00 59.65  ?  368 GLY B CA  1 
ATOM   6532 C  C   . GLY B 1 368 ? -89.872 -21.056 -58.186 1.00 62.06  ?  368 GLY B C   1 
ATOM   6533 O  O   . GLY B 1 368 ? -89.976 -20.532 -59.316 1.00 60.25  ?  368 GLY B O   1 
ATOM   6534 N  N   . ALA B 1 369 ? -89.040 -20.637 -57.225 1.00 63.35  ?  369 ALA B N   1 
ATOM   6535 C  CA  . ALA B 1 369 ? -88.138 -19.464 -57.321 1.00 64.31  ?  369 ALA B CA  1 
ATOM   6536 C  C   . ALA B 1 369 ? -86.951 -19.785 -58.237 1.00 67.03  ?  369 ALA B C   1 
ATOM   6537 O  O   . ALA B 1 369 ? -86.003 -20.433 -57.760 1.00 73.18  ?  369 ALA B O   1 
ATOM   6538 C  CB  . ALA B 1 369 ? -87.672 -19.062 -55.943 1.00 62.60  ?  369 ALA B CB  1 
ATOM   6539 N  N   . THR B 1 370 ? -87.006 -19.342 -59.499 1.00 69.89  ?  370 THR B N   1 
ATOM   6540 C  CA  . THR B 1 370 ? -85.906 -19.501 -60.500 1.00 73.00  ?  370 THR B CA  1 
ATOM   6541 C  C   . THR B 1 370 ? -85.474 -18.133 -61.020 1.00 75.32  ?  370 THR B C   1 
ATOM   6542 O  O   . THR B 1 370 ? -86.196 -17.153 -60.854 1.00 76.41  ?  370 THR B O   1 
ATOM   6543 C  CB  . THR B 1 370 ? -86.322 -20.407 -61.667 1.00 74.56  ?  370 THR B CB  1 
ATOM   6544 O  OG1 . THR B 1 370 ? -87.132 -19.655 -62.572 1.00 72.70  ?  370 THR B OG1 1 
ATOM   6545 C  CG2 . THR B 1 370 ? -87.070 -21.643 -61.217 1.00 77.35  ?  370 THR B CG2 1 
ATOM   6546 N  N   . PRO B 1 371 ? -84.286 -18.018 -61.663 1.00 78.26  ?  371 PRO B N   1 
ATOM   6547 C  CA  . PRO B 1 371 ? -83.899 -16.780 -62.336 1.00 78.67  ?  371 PRO B CA  1 
ATOM   6548 C  C   . PRO B 1 371 ? -84.882 -16.438 -63.453 1.00 79.94  ?  371 PRO B C   1 
ATOM   6549 O  O   . PRO B 1 371 ? -85.568 -17.322 -63.963 1.00 77.76  ?  371 PRO B O   1 
ATOM   6550 C  CB  . PRO B 1 371 ? -82.506 -17.076 -62.915 1.00 78.84  ?  371 PRO B CB  1 
ATOM   6551 C  CG  . PRO B 1 371 ? -82.004 -18.260 -62.115 1.00 79.05  ?  371 PRO B CG  1 
ATOM   6552 C  CD  . PRO B 1 371 ? -83.247 -19.055 -61.773 1.00 79.46  ?  371 PRO B CD  1 
ATOM   6553 N  N   . PRO B 1 372 ? -84.985 -15.152 -63.863 1.00 83.10  ?  372 PRO B N   1 
ATOM   6554 C  CA  . PRO B 1 372 ? -85.831 -14.771 -64.994 1.00 83.53  ?  372 PRO B CA  1 
ATOM   6555 C  C   . PRO B 1 372 ? -85.488 -15.544 -66.276 1.00 84.30  ?  372 PRO B C   1 
ATOM   6556 O  O   . PRO B 1 372 ? -84.352 -15.956 -66.430 1.00 83.99  ?  372 PRO B O   1 
ATOM   6557 C  CB  . PRO B 1 372 ? -85.543 -13.273 -65.180 1.00 85.17  ?  372 PRO B CB  1 
ATOM   6558 C  CG  . PRO B 1 372 ? -85.060 -12.813 -63.819 1.00 85.62  ?  372 PRO B CG  1 
ATOM   6559 C  CD  . PRO B 1 372 ? -84.303 -13.998 -63.257 1.00 84.64  ?  372 PRO B CD  1 
ATOM   6560 N  N   . HIS B 1 373 ? -86.481 -15.712 -67.154 1.00 87.25  ?  373 HIS B N   1 
ATOM   6561 C  CA  . HIS B 1 373 ? -86.391 -16.477 -68.429 1.00 91.91  ?  373 HIS B CA  1 
ATOM   6562 C  C   . HIS B 1 373 ? -85.134 -16.072 -69.211 1.00 93.75  ?  373 HIS B C   1 
ATOM   6563 O  O   . HIS B 1 373 ? -84.364 -16.973 -69.604 1.00 88.40  ?  373 HIS B O   1 
ATOM   6564 C  CB  . HIS B 1 373 ? -87.663 -16.268 -69.262 1.00 95.47  ?  373 HIS B CB  1 
ATOM   6565 C  CG  . HIS B 1 373 ? -87.849 -17.292 -70.330 1.00 101.86 ?  373 HIS B CG  1 
ATOM   6566 N  ND1 . HIS B 1 373 ? -88.570 -18.455 -70.120 1.00 105.50 ?  373 HIS B ND1 1 
ATOM   6567 C  CD2 . HIS B 1 373 ? -87.409 -17.341 -71.607 1.00 103.90 ?  373 HIS B CD2 1 
ATOM   6568 C  CE1 . HIS B 1 373 ? -88.567 -19.176 -71.223 1.00 107.63 ?  373 HIS B CE1 1 
ATOM   6569 N  NE2 . HIS B 1 373 ? -87.860 -18.515 -72.151 1.00 109.44 ?  373 HIS B NE2 1 
ATOM   6570 N  N   . ASP B 1 374 ? -84.940 -14.762 -69.403 1.00 99.78  ?  374 ASP B N   1 
ATOM   6571 C  CA  . ASP B 1 374 ? -83.889 -14.150 -70.267 1.00 99.75  ?  374 ASP B CA  1 
ATOM   6572 C  C   . ASP B 1 374 ? -82.481 -14.440 -69.721 1.00 95.91  ?  374 ASP B C   1 
ATOM   6573 O  O   . ASP B 1 374 ? -81.531 -14.425 -70.529 1.00 96.33  ?  374 ASP B O   1 
ATOM   6574 C  CB  . ASP B 1 374 ? -84.114 -12.640 -70.418 1.00 104.73 ?  374 ASP B CB  1 
ATOM   6575 C  CG  . ASP B 1 374 ? -84.064 -11.856 -69.114 1.00 109.02 ?  374 ASP B CG  1 
ATOM   6576 O  OD1 . ASP B 1 374 ? -82.965 -11.757 -68.524 1.00 111.47 -1 374 ASP B OD1 1 
ATOM   6577 O  OD2 . ASP B 1 374 ? -85.125 -11.349 -68.695 1.00 108.37 ?  374 ASP B OD2 1 
ATOM   6578 N  N   . ALA B 1 375 ? -82.351 -14.678 -68.411 1.00 90.01  ?  375 ALA B N   1 
ATOM   6579 C  CA  . ALA B 1 375 ? -81.059 -14.836 -67.696 1.00 84.74  ?  375 ALA B CA  1 
ATOM   6580 C  C   . ALA B 1 375 ? -80.493 -16.249 -67.882 1.00 81.77  ?  375 ALA B C   1 
ATOM   6581 O  O   . ALA B 1 375 ? -79.272 -16.416 -67.708 1.00 78.35  ?  375 ALA B O   1 
ATOM   6582 C  CB  . ALA B 1 375 ? -81.244 -14.526 -66.232 1.00 85.84  ?  375 ALA B CB  1 
ATOM   6583 N  N   . ILE B 1 376 ? -81.347 -17.219 -68.223 1.00 82.56  ?  376 ILE B N   1 
ATOM   6584 C  CA  . ILE B 1 376 ? -81.042 -18.681 -68.147 1.00 84.11  ?  376 ILE B CA  1 
ATOM   6585 C  C   . ILE B 1 376 ? -79.972 -19.072 -69.165 1.00 85.15  ?  376 ILE B C   1 
ATOM   6586 O  O   . ILE B 1 376 ? -79.037 -19.785 -68.807 1.00 87.19  ?  376 ILE B O   1 
ATOM   6587 C  CB  . ILE B 1 376 ? -82.326 -19.521 -68.306 1.00 83.59  ?  376 ILE B CB  1 
ATOM   6588 C  CG1 . ILE B 1 376 ? -83.302 -19.292 -67.146 1.00 83.44  ?  376 ILE B CG1 1 
ATOM   6589 C  CG2 . ILE B 1 376 ? -81.992 -20.995 -68.484 1.00 83.58  ?  376 ILE B CG2 1 
ATOM   6590 C  CD1 . ILE B 1 376 ? -82.777 -19.704 -65.787 1.00 82.46  ?  376 ILE B CD1 1 
ATOM   6591 N  N   . PRO B 1 377 ? -80.058 -18.651 -70.450 1.00 88.09  ?  377 PRO B N   1 
ATOM   6592 C  CA  . PRO B 1 377 ? -79.042 -19.012 -71.443 1.00 86.97  ?  377 PRO B CA  1 
ATOM   6593 C  C   . PRO B 1 377 ? -77.616 -18.647 -71.001 1.00 86.88  ?  377 PRO B C   1 
ATOM   6594 O  O   . PRO B 1 377 ? -76.709 -19.418 -71.265 1.00 84.32  ?  377 PRO B O   1 
ATOM   6595 C  CB  . PRO B 1 377 ? -79.438 -18.200 -72.684 1.00 86.41  ?  377 PRO B CB  1 
ATOM   6596 C  CG  . PRO B 1 377 ? -80.926 -17.990 -72.519 1.00 87.94  ?  377 PRO B CG  1 
ATOM   6597 C  CD  . PRO B 1 377 ? -81.124 -17.816 -71.027 1.00 87.93  ?  377 PRO B CD  1 
ATOM   6598 N  N   . ARG B 1 378 ? -77.470 -17.502 -70.327 1.00 88.65  ?  378 ARG B N   1 
ATOM   6599 C  CA  . ARG B 1 378 ? -76.167 -17.005 -69.796 1.00 93.94  ?  378 ARG B CA  1 
ATOM   6600 C  C   . ARG B 1 378 ? -75.611 -18.027 -68.794 1.00 90.69  ?  378 ARG B C   1 
ATOM   6601 O  O   . ARG B 1 378 ? -74.461 -18.478 -68.990 1.00 88.53  ?  378 ARG B O   1 
ATOM   6602 C  CB  . ARG B 1 378 ? -76.345 -15.622 -69.162 1.00 102.70 ?  378 ARG B CB  1 
ATOM   6603 C  CG  . ARG B 1 378 ? -75.043 -14.882 -68.891 1.00 110.88 ?  378 ARG B CG  1 
ATOM   6604 C  CD  . ARG B 1 378 ? -75.267 -13.413 -68.579 1.00 118.98 ?  378 ARG B CD  1 
ATOM   6605 N  NE  . ARG B 1 378 ? -74.013 -12.668 -68.555 1.00 126.36 ?  378 ARG B NE  1 
ATOM   6606 C  CZ  . ARG B 1 378 ? -73.340 -12.254 -69.630 1.00 131.12 ?  378 ARG B CZ  1 
ATOM   6607 N  NH1 . ARG B 1 378 ? -73.789 -12.503 -70.851 1.00 131.41 ?  378 ARG B NH1 1 
ATOM   6608 N  NH2 . ARG B 1 378 ? -72.207 -11.589 -69.477 1.00 133.02 ?  378 ARG B NH2 1 
ATOM   6609 N  N   . LEU B 1 379 ? -76.408 -18.388 -67.780 1.00 84.92  ?  379 LEU B N   1 
ATOM   6610 C  CA  . LEU B 1 379 ? -76.052 -19.397 -66.741 1.00 83.99  ?  379 LEU B CA  1 
ATOM   6611 C  C   . LEU B 1 379 ? -75.702 -20.735 -67.403 1.00 81.69  ?  379 LEU B C   1 
ATOM   6612 O  O   . LEU B 1 379 ? -74.682 -21.331 -67.017 1.00 80.10  ?  379 LEU B O   1 
ATOM   6613 C  CB  . LEU B 1 379 ? -77.224 -19.573 -65.771 1.00 84.19  ?  379 LEU B CB  1 
ATOM   6614 C  CG  . LEU B 1 379 ? -77.462 -18.419 -64.801 1.00 87.19  ?  379 LEU B CG  1 
ATOM   6615 C  CD1 . LEU B 1 379 ? -78.695 -18.683 -63.952 1.00 87.63  ?  379 LEU B CD1 1 
ATOM   6616 C  CD2 . LEU B 1 379 ? -76.248 -18.185 -63.914 1.00 88.86  ?  379 LEU B CD2 1 
ATOM   6617 N  N   . ALA B 1 380 ? -76.532 -21.186 -68.348 1.00 81.26  ?  380 ALA B N   1 
ATOM   6618 C  CA  . ALA B 1 380 ? -76.363 -22.460 -69.089 1.00 85.25  ?  380 ALA B CA  1 
ATOM   6619 C  C   . ALA B 1 380 ? -74.977 -22.491 -69.744 1.00 86.62  ?  380 ALA B C   1 
ATOM   6620 O  O   . ALA B 1 380 ? -74.270 -23.507 -69.587 1.00 87.02  ?  380 ALA B O   1 
ATOM   6621 C  CB  . ALA B 1 380 ? -77.460 -22.621 -70.111 1.00 87.19  ?  380 ALA B CB  1 
ATOM   6622 N  N   . ARG B 1 381 ? -74.613 -21.409 -70.443 1.00 87.42  ?  381 ARG B N   1 
ATOM   6623 C  CA  . ARG B 1 381 ? -73.274 -21.238 -71.076 1.00 85.07  ?  381 ARG B CA  1 
ATOM   6624 C  C   . ARG B 1 381 ? -72.183 -21.307 -69.998 1.00 82.69  ?  381 ARG B C   1 
ATOM   6625 O  O   . ARG B 1 381 ? -71.209 -22.061 -70.196 1.00 81.62  ?  381 ARG B O   1 
ATOM   6626 C  CB  . ARG B 1 381 ? -73.201 -19.915 -71.847 1.00 84.96  ?  381 ARG B CB  1 
ATOM   6627 N  N   . PHE B 1 382 ? -72.347 -20.560 -68.899 1.00 80.00  ?  382 PHE B N   1 
ATOM   6628 C  CA  . PHE B 1 382 ? -71.347 -20.453 -67.801 1.00 80.02  ?  382 PHE B CA  1 
ATOM   6629 C  C   . PHE B 1 382 ? -71.139 -21.817 -67.136 1.00 80.16  ?  382 PHE B C   1 
ATOM   6630 O  O   . PHE B 1 382 ? -69.976 -22.188 -66.885 1.00 76.68  ?  382 PHE B O   1 
ATOM   6631 C  CB  . PHE B 1 382 ? -71.761 -19.438 -66.733 1.00 81.65  ?  382 PHE B CB  1 
ATOM   6632 C  CG  . PHE B 1 382 ? -70.855 -19.449 -65.526 1.00 84.33  ?  382 PHE B CG  1 
ATOM   6633 C  CD1 . PHE B 1 382 ? -69.601 -18.858 -65.577 1.00 84.75  ?  382 PHE B CD1 1 
ATOM   6634 C  CD2 . PHE B 1 382 ? -71.238 -20.079 -64.351 1.00 85.94  ?  382 PHE B CD2 1 
ATOM   6635 C  CE1 . PHE B 1 382 ? -68.760 -18.879 -64.475 1.00 85.51  ?  382 PHE B CE1 1 
ATOM   6636 C  CE2 . PHE B 1 382 ? -70.395 -20.100 -63.250 1.00 86.80  ?  382 PHE B CE2 1 
ATOM   6637 C  CZ  . PHE B 1 382 ? -69.158 -19.500 -63.314 1.00 85.98  ?  382 PHE B CZ  1 
ATOM   6638 N  N   . VAL B 1 383 ? -72.236 -22.514 -66.825 1.00 83.48  ?  383 VAL B N   1 
ATOM   6639 C  CA  . VAL B 1 383 ? -72.214 -23.860 -66.177 1.00 85.77  ?  383 VAL B CA  1 
ATOM   6640 C  C   . VAL B 1 383 ? -71.385 -24.803 -67.057 1.00 83.89  ?  383 VAL B C   1 
ATOM   6641 O  O   . VAL B 1 383 ? -70.490 -25.469 -66.512 1.00 81.67  ?  383 VAL B O   1 
ATOM   6642 C  CB  . VAL B 1 383 ? -73.637 -24.399 -65.919 1.00 87.10  ?  383 VAL B CB  1 
ATOM   6643 C  CG1 . VAL B 1 383 ? -73.656 -25.905 -65.690 1.00 86.18  ?  383 VAL B CG1 1 
ATOM   6644 C  CG2 . VAL B 1 383 ? -74.295 -23.681 -64.751 1.00 86.08  ?  383 VAL B CG2 1 
ATOM   6645 N  N   . ALA B 1 384 ? -71.646 -24.807 -68.369 1.00 82.70  ?  384 ALA B N   1 
ATOM   6646 C  CA  . ALA B 1 384 ? -71.004 -25.698 -69.368 1.00 86.83  ?  384 ALA B CA  1 
ATOM   6647 C  C   . ALA B 1 384 ? -69.483 -25.480 -69.411 1.00 90.15  ?  384 ALA B C   1 
ATOM   6648 O  O   . ALA B 1 384 ? -68.763 -26.442 -69.755 1.00 89.00  ?  384 ALA B O   1 
ATOM   6649 C  CB  . ALA B 1 384 ? -71.628 -25.486 -70.726 1.00 86.37  ?  384 ALA B CB  1 
ATOM   6650 N  N   . SER B 1 385 ? -69.013 -24.275 -69.073 1.00 92.59  ?  385 SER B N   1 
ATOM   6651 C  CA  . SER B 1 385 ? -67.575 -23.880 -69.137 1.00 93.88  ?  385 SER B CA  1 
ATOM   6652 C  C   . SER B 1 385 ? -66.805 -24.360 -67.895 1.00 92.33  ?  385 SER B C   1 
ATOM   6653 O  O   . SER B 1 385 ? -65.641 -24.770 -68.063 1.00 94.41  ?  385 SER B O   1 
ATOM   6654 C  CB  . SER B 1 385 ? -67.421 -22.394 -69.336 1.00 94.80  ?  385 SER B CB  1 
ATOM   6655 O  OG  . SER B 1 385 ? -67.697 -21.686 -68.138 1.00 97.18  ?  385 SER B OG  1 
ATOM   6656 N  N   . VAL B 1 386 ? -67.417 -24.307 -66.705 1.00 91.27  ?  386 VAL B N   1 
ATOM   6657 C  CA  . VAL B 1 386 ? -66.744 -24.612 -65.400 1.00 91.93  ?  386 VAL B CA  1 
ATOM   6658 C  C   . VAL B 1 386 ? -67.195 -25.978 -64.863 1.00 92.49  ?  386 VAL B C   1 
ATOM   6659 O  O   . VAL B 1 386 ? -66.559 -26.458 -63.903 1.00 92.39  ?  386 VAL B O   1 
ATOM   6660 C  CB  . VAL B 1 386 ? -66.984 -23.507 -64.352 1.00 92.72  ?  386 VAL B CB  1 
ATOM   6661 C  CG1 . VAL B 1 386 ? -66.554 -22.142 -64.866 1.00 94.90  ?  386 VAL B CG1 1 
ATOM   6662 C  CG2 . VAL B 1 386 ? -68.424 -23.464 -63.862 1.00 94.19  ?  386 VAL B CG2 1 
ATOM   6663 N  N   . SER B 1 387 ? -68.243 -26.575 -65.438 1.00 92.40  ?  387 SER B N   1 
ATOM   6664 C  CA  . SER B 1 387 ? -68.841 -27.856 -64.961 1.00 93.33  ?  387 SER B CA  1 
ATOM   6665 C  C   . SER B 1 387 ? -67.836 -29.003 -65.123 1.00 93.17  ?  387 SER B C   1 
ATOM   6666 O  O   . SER B 1 387 ? -67.656 -29.772 -64.157 1.00 91.66  ?  387 SER B O   1 
ATOM   6667 C  CB  . SER B 1 387 ? -70.132 -28.176 -65.675 1.00 95.02  ?  387 SER B CB  1 
ATOM   6668 O  OG  . SER B 1 387 ? -70.509 -29.529 -65.465 1.00 95.65  ?  387 SER B OG  1 
ATOM   6669 N  N   . GLU B 1 388 ? -67.226 -29.115 -66.308 1.00 91.71  ?  388 GLU B N   1 
ATOM   6670 C  CA  . GLU B 1 388 ? -66.365 -30.261 -66.711 1.00 89.93  ?  388 GLU B CA  1 
ATOM   6671 C  C   . GLU B 1 388 ? -67.174 -31.563 -66.599 1.00 86.30  ?  388 GLU B C   1 
ATOM   6672 O  O   . GLU B 1 388 ? -66.590 -32.590 -66.204 1.00 89.54  ?  388 GLU B O   1 
ATOM   6673 C  CB  . GLU B 1 388 ? -65.096 -30.301 -65.852 1.00 89.67  ?  388 GLU B CB  1 
ATOM   6674 N  N   . GLY B 1 389 ? -68.473 -31.507 -66.923 1.00 81.95  ?  389 GLY B N   1 
ATOM   6675 C  CA  . GLY B 1 389 ? -69.389 -32.666 -66.968 1.00 79.45  ?  389 GLY B CA  1 
ATOM   6676 C  C   . GLY B 1 389 ? -69.677 -33.257 -65.595 1.00 76.56  ?  389 GLY B C   1 
ATOM   6677 O  O   . GLY B 1 389 ? -70.202 -34.392 -65.544 1.00 73.57  ?  389 GLY B O   1 
ATOM   6678 N  N   . ARG B 1 390 ? -69.372 -32.516 -64.524 1.00 72.57  ?  390 ARG B N   1 
ATOM   6679 C  CA  . ARG B 1 390 ? -69.551 -32.960 -63.114 1.00 69.59  ?  390 ARG B CA  1 
ATOM   6680 C  C   . ARG B 1 390 ? -70.572 -32.036 -62.434 1.00 68.16  ?  390 ARG B C   1 
ATOM   6681 O  O   . ARG B 1 390 ? -70.888 -30.973 -63.008 1.00 67.75  ?  390 ARG B O   1 
ATOM   6682 C  CB  . ARG B 1 390 ? -68.198 -32.957 -62.391 1.00 67.04  ?  390 ARG B CB  1 
ATOM   6683 N  N   . VAL B 1 391 ? -71.082 -32.431 -61.265 1.00 66.34  ?  391 VAL B N   1 
ATOM   6684 C  CA  . VAL B 1 391 ? -71.995 -31.589 -60.436 1.00 64.31  ?  391 VAL B CA  1 
ATOM   6685 C  C   . VAL B 1 391 ? -71.229 -30.330 -60.027 1.00 65.53  ?  391 VAL B C   1 
ATOM   6686 O  O   . VAL B 1 391 ? -70.181 -30.470 -59.374 1.00 72.57  ?  391 VAL B O   1 
ATOM   6687 C  CB  . VAL B 1 391 ? -72.524 -32.342 -59.201 1.00 62.95  ?  391 VAL B CB  1 
ATOM   6688 C  CG1 . VAL B 1 391 ? -73.217 -31.410 -58.221 1.00 62.77  ?  391 VAL B CG1 1 
ATOM   6689 C  CG2 . VAL B 1 391 ? -73.450 -33.480 -59.595 1.00 64.89  ?  391 VAL B CG2 1 
ATOM   6690 N  N   . TRP B 1 392 ? -71.733 -29.158 -60.417 1.00 67.11  ?  392 TRP B N   1 
ATOM   6691 C  CA  . TRP B 1 392 ? -71.212 -27.825 -60.012 1.00 65.66  ?  392 TRP B CA  1 
ATOM   6692 C  C   . TRP B 1 392 ? -72.256 -27.148 -59.121 1.00 63.49  ?  392 TRP B C   1 
ATOM   6693 O  O   . TRP B 1 392 ? -73.456 -27.324 -59.392 1.00 68.35  ?  392 TRP B O   1 
ATOM   6694 C  CB  . TRP B 1 392 ? -70.876 -26.977 -61.245 1.00 67.73  ?  392 TRP B CB  1 
ATOM   6695 C  CG  . TRP B 1 392 ? -70.114 -25.729 -60.925 1.00 71.09  ?  392 TRP B CG  1 
ATOM   6696 C  CD1 . TRP B 1 392 ? -68.760 -25.598 -60.813 1.00 73.94  ?  392 TRP B CD1 1 
ATOM   6697 C  CD2 . TRP B 1 392 ? -70.665 -24.427 -60.661 1.00 73.88  ?  392 TRP B CD2 1 
ATOM   6698 N  NE1 . TRP B 1 392 ? -68.430 -24.307 -60.504 1.00 76.55  ?  392 TRP B NE1 1 
ATOM   6699 C  CE2 . TRP B 1 392 ? -69.577 -23.565 -60.401 1.00 74.99  ?  392 TRP B CE2 1 
ATOM   6700 C  CE3 . TRP B 1 392 ? -71.963 -23.906 -60.619 1.00 73.94  ?  392 TRP B CE3 1 
ATOM   6701 C  CZ2 . TRP B 1 392 ? -69.752 -22.214 -60.102 1.00 74.42  ?  392 TRP B CZ2 1 
ATOM   6702 C  CZ3 . TRP B 1 392 ? -72.134 -22.570 -60.329 1.00 75.81  ?  392 TRP B CZ3 1 
ATOM   6703 C  CH2 . TRP B 1 392 ? -71.043 -21.738 -60.072 1.00 75.68  ?  392 TRP B CH2 1 
ATOM   6704 N  N   . ALA B 1 393 ? -71.822 -26.406 -58.102 1.00 60.72  ?  393 ALA B N   1 
ATOM   6705 C  CA  . ALA B 1 393 ? -72.725 -25.726 -57.144 1.00 60.64  ?  393 ALA B CA  1 
ATOM   6706 C  C   . ALA B 1 393 ? -72.046 -24.497 -56.535 1.00 60.66  ?  393 ALA B C   1 
ATOM   6707 O  O   . ALA B 1 393 ? -70.819 -24.514 -56.385 1.00 63.08  ?  393 ALA B O   1 
ATOM   6708 C  CB  . ALA B 1 393 ? -73.150 -26.701 -56.075 1.00 61.01  ?  393 ALA B CB  1 
ATOM   6709 N  N   . THR B 1 394 ? -72.834 -23.477 -56.190 1.00 62.38  ?  394 THR B N   1 
ATOM   6710 C  CA  . THR B 1 394 ? -72.374 -22.259 -55.468 1.00 64.09  ?  394 THR B CA  1 
ATOM   6711 C  C   . THR B 1 394 ? -73.541 -21.728 -54.631 1.00 67.22  ?  394 THR B C   1 
ATOM   6712 O  O   . THR B 1 394 ? -74.697 -21.921 -55.055 1.00 68.42  ?  394 THR B O   1 
ATOM   6713 C  CB  . THR B 1 394 ? -71.832 -21.195 -56.433 1.00 63.92  ?  394 THR B CB  1 
ATOM   6714 O  OG1 . THR B 1 394 ? -71.338 -20.101 -55.659 1.00 62.46  ?  394 THR B OG1 1 
ATOM   6715 C  CG2 . THR B 1 394 ? -72.865 -20.686 -57.415 1.00 63.48  ?  394 THR B CG2 1 
ATOM   6716 N  N   . HIS B 1 395 ? -73.243 -21.082 -53.502 1.00 69.43  ?  395 HIS B N   1 
ATOM   6717 C  CA  . HIS B 1 395 ? -74.244 -20.413 -52.626 1.00 73.58  ?  395 HIS B CA  1 
ATOM   6718 C  C   . HIS B 1 395 ? -74.174 -18.896 -52.833 1.00 71.23  ?  395 HIS B C   1 
ATOM   6719 O  O   . HIS B 1 395 ? -74.905 -18.173 -52.132 1.00 68.73  ?  395 HIS B O   1 
ATOM   6720 C  CB  . HIS B 1 395 ? -74.061 -20.831 -51.160 1.00 79.47  ?  395 HIS B CB  1 
ATOM   6721 C  CG  . HIS B 1 395 ? -72.759 -20.433 -50.550 1.00 85.11  ?  395 HIS B CG  1 
ATOM   6722 N  ND1 . HIS B 1 395 ? -71.568 -21.050 -50.881 1.00 89.72  ?  395 HIS B ND1 1 
ATOM   6723 C  CD2 . HIS B 1 395 ? -72.462 -19.512 -49.609 1.00 89.44  ?  395 HIS B CD2 1 
ATOM   6724 C  CE1 . HIS B 1 395 ? -70.589 -20.513 -50.184 1.00 92.74  ?  395 HIS B CE1 1 
ATOM   6725 N  NE2 . HIS B 1 395 ? -71.112 -19.565 -49.395 1.00 94.03  ?  395 HIS B NE2 1 
ATOM   6726 N  N   . ALA B 1 396 ? -73.341 -18.453 -53.778 1.00 71.89  ?  396 ALA B N   1 
ATOM   6727 C  CA  . ALA B 1 396 ? -73.105 -17.032 -54.123 1.00 75.10  ?  396 ALA B CA  1 
ATOM   6728 C  C   . ALA B 1 396 ? -72.963 -16.910 -55.642 1.00 75.03  ?  396 ALA B C   1 
ATOM   6729 O  O   . ALA B 1 396 ? -71.834 -16.712 -56.130 1.00 74.62  ?  396 ALA B O   1 
ATOM   6730 C  CB  . ALA B 1 396 ? -71.880 -16.522 -53.404 1.00 76.41  ?  396 ALA B CB  1 
ATOM   6731 N  N   . LEU B 1 397 ? -74.081 -17.038 -56.354 1.00 77.12  ?  397 LEU B N   1 
ATOM   6732 C  CA  . LEU B 1 397 ? -74.119 -17.044 -57.840 1.00 79.75  ?  397 LEU B CA  1 
ATOM   6733 C  C   . LEU B 1 397 ? -73.571 -15.712 -58.366 1.00 79.17  ?  397 LEU B C   1 
ATOM   6734 O  O   . LEU B 1 397 ? -72.864 -15.743 -59.390 1.00 76.11  ?  397 LEU B O   1 
ATOM   6735 C  CB  . LEU B 1 397 ? -75.557 -17.293 -58.308 1.00 80.32  ?  397 LEU B CB  1 
ATOM   6736 C  CG  . LEU B 1 397 ? -75.738 -17.599 -59.794 1.00 80.95  ?  397 LEU B CG  1 
ATOM   6737 C  CD1 . LEU B 1 397 ? -74.744 -18.646 -60.279 1.00 80.96  ?  397 LEU B CD1 1 
ATOM   6738 C  CD2 . LEU B 1 397 ? -77.160 -18.059 -60.065 1.00 84.04  ?  397 LEU B CD2 1 
ATOM   6739 N  N   . SER B 1 398 ? -73.857 -14.605 -57.668 1.00 82.21  ?  398 SER B N   1 
ATOM   6740 C  CA  . SER B 1 398 ? -73.463 -13.219 -58.055 1.00 85.70  ?  398 SER B CA  1 
ATOM   6741 C  C   . SER B 1 398 ? -71.936 -13.087 -58.151 1.00 88.56  ?  398 SER B C   1 
ATOM   6742 O  O   . SER B 1 398 ? -71.470 -12.280 -58.981 1.00 91.81  ?  398 SER B O   1 
ATOM   6743 C  CB  . SER B 1 398 ? -74.028 -12.201 -57.097 1.00 86.23  ?  398 SER B CB  1 
ATOM   6744 O  OG  . SER B 1 398 ? -73.330 -12.232 -55.862 1.00 88.43  ?  398 SER B OG  1 
ATOM   6745 N  N   . GLN B 1 399 ? -71.190 -13.830 -57.327 1.00 88.92  ?  399 GLN B N   1 
ATOM   6746 C  CA  . GLN B 1 399 ? -69.703 -13.769 -57.266 1.00 90.52  ?  399 GLN B CA  1 
ATOM   6747 C  C   . GLN B 1 399 ? -69.094 -14.358 -58.543 1.00 92.35  ?  399 GLN B C   1 
ATOM   6748 O  O   . GLN B 1 399 ? -68.011 -13.888 -58.941 1.00 99.69  ?  399 GLN B O   1 
ATOM   6749 C  CB  . GLN B 1 399 ? -69.174 -14.502 -56.034 1.00 90.37  ?  399 GLN B CB  1 
ATOM   6750 C  CG  . GLN B 1 399 ? -69.520 -13.803 -54.729 1.00 92.72  ?  399 GLN B CG  1 
ATOM   6751 C  CD  . GLN B 1 399 ? -68.843 -14.436 -53.539 1.00 94.80  ?  399 GLN B CD  1 
ATOM   6752 O  OE1 . GLN B 1 399 ? -67.890 -15.202 -53.675 1.00 97.70  ?  399 GLN B OE1 1 
ATOM   6753 N  NE2 . GLN B 1 399 ? -69.333 -14.112 -52.353 1.00 96.82  ?  399 GLN B NE2 1 
ATOM   6754 N  N   . ALA B 1 400 ? -69.755 -15.348 -59.147 1.00 92.53  ?  400 ALA B N   1 
ATOM   6755 C  CA  . ALA B 1 400 ? -69.309 -16.030 -60.387 1.00 92.35  ?  400 ALA B CA  1 
ATOM   6756 C  C   . ALA B 1 400 ? -69.960 -15.382 -61.618 1.00 92.27  ?  400 ALA B C   1 
ATOM   6757 O  O   . ALA B 1 400 ? -69.370 -15.484 -62.709 1.00 95.59  ?  400 ALA B O   1 
ATOM   6758 C  CB  . ALA B 1 400 ? -69.621 -17.503 -60.303 1.00 92.75  ?  400 ALA B CB  1 
ATOM   6759 N  N   . ILE B 1 401 ? -71.126 -14.747 -61.446 1.00 90.99  ?  401 ILE B N   1 
ATOM   6760 C  CA  . ILE B 1 401 ? -71.889 -14.044 -62.524 1.00 91.49  ?  401 ILE B CA  1 
ATOM   6761 C  C   . ILE B 1 401 ? -72.312 -12.676 -61.996 1.00 95.36  ?  401 ILE B C   1 
ATOM   6762 O  O   . ILE B 1 401 ? -73.392 -12.543 -61.424 1.00 98.77  ?  401 ILE B O   1 
ATOM   6763 C  CB  . ILE B 1 401 ? -73.115 -14.868 -62.972 1.00 91.69  ?  401 ILE B CB  1 
ATOM   6764 C  CG1 . ILE B 1 401 ? -72.764 -16.326 -63.284 1.00 92.52  ?  401 ILE B CG1 1 
ATOM   6765 C  CG2 . ILE B 1 401 ? -73.817 -14.194 -64.143 1.00 91.03  ?  401 ILE B CG2 1 
ATOM   6766 C  CD1 . ILE B 1 401 ? -71.933 -16.510 -64.526 1.00 93.68  ?  401 ILE B CD1 1 
ATOM   6767 N  N   . PRO B 1 402 ? -71.490 -11.614 -62.168 1.00 97.16  ?  402 PRO B N   1 
ATOM   6768 C  CA  . PRO B 1 402 ? -71.833 -10.285 -61.655 1.00 94.75  ?  402 PRO B CA  1 
ATOM   6769 C  C   . PRO B 1 402 ? -73.283 -9.869  -61.950 1.00 94.01  ?  402 PRO B C   1 
ATOM   6770 O  O   . PRO B 1 402 ? -73.873 -9.188  -61.131 1.00 93.42  ?  402 PRO B O   1 
ATOM   6771 C  CB  . PRO B 1 402 ? -70.841 -9.374  -62.391 1.00 97.84  ?  402 PRO B CB  1 
ATOM   6772 C  CG  . PRO B 1 402 ? -69.624 -10.254 -62.602 1.00 98.47  ?  402 PRO B CG  1 
ATOM   6773 C  CD  . PRO B 1 402 ? -70.190 -11.635 -62.860 1.00 97.97  ?  402 PRO B CD  1 
ATOM   6774 N  N   . GLU B 1 403 ? -73.815 -10.313 -63.094 1.00 95.55  ?  403 GLU B N   1 
ATOM   6775 C  CA  . GLU B 1 403 ? -75.185 -10.001 -63.594 1.00 99.28  ?  403 GLU B CA  1 
ATOM   6776 C  C   . GLU B 1 403 ? -76.245 -10.570 -62.641 1.00 95.95  ?  403 GLU B C   1 
ATOM   6777 O  O   . GLU B 1 403 ? -77.315 -9.941  -62.509 1.00 96.58  ?  403 GLU B O   1 
ATOM   6778 C  CB  . GLU B 1 403 ? -75.392 -10.574 -65.000 1.00 105.59 ?  403 GLU B CB  1 
ATOM   6779 C  CG  . GLU B 1 403 ? -74.477 -9.975  -66.058 1.00 111.65 ?  403 GLU B CG  1 
ATOM   6780 C  CD  . GLU B 1 403 ? -73.054 -10.513 -66.091 1.00 117.96 ?  403 GLU B CD  1 
ATOM   6781 O  OE1 . GLU B 1 403 ? -72.290 -10.097 -66.984 1.00 125.17 ?  403 GLU B OE1 1 
ATOM   6782 O  OE2 . GLU B 1 403 ? -72.710 -11.349 -65.228 1.00 121.14 -1 403 GLU B OE2 1 
ATOM   6783 N  N   . ALA B 1 404 ? -75.952 -11.706 -61.998 1.00 91.75  ?  404 ALA B N   1 
ATOM   6784 C  CA  . ALA B 1 404 ? -76.903 -12.508 -61.187 1.00 88.50  ?  404 ALA B CA  1 
ATOM   6785 C  C   . ALA B 1 404 ? -77.306 -11.769 -59.903 1.00 86.14  ?  404 ALA B C   1 
ATOM   6786 O  O   . ALA B 1 404 ? -78.263 -12.227 -59.241 1.00 84.22  ?  404 ALA B O   1 
ATOM   6787 C  CB  . ALA B 1 404 ? -76.302 -13.857 -60.879 1.00 89.28  ?  404 ALA B CB  1 
ATOM   6788 N  N   . GLU B 1 405 ? -76.604 -10.684 -59.560 1.00 83.62  ?  405 GLU B N   1 
ATOM   6789 C  CA  . GLU B 1 405 ? -76.949 -9.773  -58.434 1.00 85.34  ?  405 GLU B CA  1 
ATOM   6790 C  C   . GLU B 1 405 ? -78.379 -9.245  -58.617 1.00 83.88  ?  405 GLU B C   1 
ATOM   6791 O  O   . GLU B 1 405 ? -79.090 -9.108  -57.598 1.00 77.14  ?  405 GLU B O   1 
ATOM   6792 C  CB  . GLU B 1 405 ? -75.943 -8.621  -58.361 1.00 90.75  ?  405 GLU B CB  1 
ATOM   6793 C  CG  . GLU B 1 405 ? -76.280 -7.570  -57.315 1.00 94.24  ?  405 GLU B CG  1 
ATOM   6794 C  CD  . GLU B 1 405 ? -75.164 -6.580  -57.021 1.00 96.94  ?  405 GLU B CD  1 
ATOM   6795 O  OE1 . GLU B 1 405 ? -74.200 -6.523  -57.815 1.00 96.90  ?  405 GLU B OE1 1 
ATOM   6796 O  OE2 . GLU B 1 405 ? -75.260 -5.871  -55.992 1.00 96.51  -1 405 GLU B OE2 1 
ATOM   6797 N  N   . ILE B 1 406 ? -78.767 -8.954  -59.865 1.00 86.24  ?  406 ILE B N   1 
ATOM   6798 C  CA  . ILE B 1 406 ? -80.095 -8.379  -60.247 1.00 84.69  ?  406 ILE B CA  1 
ATOM   6799 C  C   . ILE B 1 406 ? -81.218 -9.232  -59.639 1.00 84.00  ?  406 ILE B C   1 
ATOM   6800 O  O   . ILE B 1 406 ? -82.153 -8.638  -59.068 1.00 82.94  ?  406 ILE B O   1 
ATOM   6801 C  CB  . ILE B 1 406 ? -80.229 -8.264  -61.780 1.00 79.79  ?  406 ILE B CB  1 
ATOM   6802 N  N   . TYR B 1 407 ? -81.113 -10.564 -59.732 1.00 83.73  ?  407 TYR B N   1 
ATOM   6803 C  CA  . TYR B 1 407 ? -82.188 -11.526 -59.358 1.00 82.61  ?  407 TYR B CA  1 
ATOM   6804 C  C   . TYR B 1 407 ? -81.783 -12.384 -58.150 1.00 84.18  ?  407 TYR B C   1 
ATOM   6805 O  O   . TYR B 1 407 ? -82.392 -13.454 -57.952 1.00 85.66  ?  407 TYR B O   1 
ATOM   6806 C  CB  . TYR B 1 407 ? -82.566 -12.406 -60.553 1.00 80.42  ?  407 TYR B CB  1 
ATOM   6807 C  CG  . TYR B 1 407 ? -81.435 -13.138 -61.232 1.00 77.46  ?  407 TYR B CG  1 
ATOM   6808 C  CD1 . TYR B 1 407 ? -80.870 -14.274 -60.675 1.00 77.13  ?  407 TYR B CD1 1 
ATOM   6809 C  CD2 . TYR B 1 407 ? -80.960 -12.722 -62.466 1.00 77.28  ?  407 TYR B CD2 1 
ATOM   6810 C  CE1 . TYR B 1 407 ? -79.846 -14.960 -61.311 1.00 77.88  ?  407 TYR B CE1 1 
ATOM   6811 C  CE2 . TYR B 1 407 ? -79.941 -13.397 -63.119 1.00 76.75  ?  407 TYR B CE2 1 
ATOM   6812 C  CZ  . TYR B 1 407 ? -79.380 -14.521 -62.538 1.00 77.29  ?  407 TYR B CZ  1 
ATOM   6813 O  OH  . TYR B 1 407 ? -78.375 -15.190 -63.174 1.00 75.06  ?  407 TYR B OH  1 
ATOM   6814 N  N   . ALA B 1 408 ? -80.827 -11.915 -57.342 1.00 84.74  ?  408 ALA B N   1 
ATOM   6815 C  CA  . ALA B 1 408 ? -80.269 -12.651 -56.181 1.00 84.72  ?  408 ALA B CA  1 
ATOM   6816 C  C   . ALA B 1 408 ? -81.358 -12.911 -55.129 1.00 81.84  ?  408 ALA B C   1 
ATOM   6817 O  O   . ALA B 1 408 ? -81.258 -13.928 -54.421 1.00 81.19  ?  408 ALA B O   1 
ATOM   6818 C  CB  . ALA B 1 408 ? -79.108 -11.889 -55.591 1.00 86.41  ?  408 ALA B CB  1 
ATOM   6819 N  N   . ASP B 1 409 ? -82.359 -12.033 -55.028 1.00 83.08  ?  409 ASP B N   1 
ATOM   6820 C  CA  . ASP B 1 409 ? -83.466 -12.156 -54.038 1.00 87.05  ?  409 ASP B CA  1 
ATOM   6821 C  C   . ASP B 1 409 ? -84.304 -13.406 -54.355 1.00 81.36  ?  409 ASP B C   1 
ATOM   6822 O  O   . ASP B 1 409 ? -84.917 -13.956 -53.420 1.00 77.66  ?  409 ASP B O   1 
ATOM   6823 C  CB  . ASP B 1 409 ? -84.308 -10.875 -53.983 1.00 88.67  ?  409 ASP B CB  1 
ATOM   6824 C  CG  . ASP B 1 409 ? -85.186 -10.649 -55.201 1.00 89.83  ?  409 ASP B CG  1 
ATOM   6825 O  OD1 . ASP B 1 409 ? -84.630 -10.531 -56.309 1.00 91.12  ?  409 ASP B OD1 1 
ATOM   6826 O  OD2 . ASP B 1 409 ? -86.418 -10.603 -55.030 1.00 91.24  ?  409 ASP B OD2 1 
ATOM   6827 N  N   . THR B 1 410 ? -84.311 -13.835 -55.620 1.00 78.48  ?  410 THR B N   1 
ATOM   6828 C  CA  . THR B 1 410 ? -85.066 -15.018 -56.129 1.00 78.89  ?  410 THR B CA  1 
ATOM   6829 C  C   . THR B 1 410 ? -84.146 -16.246 -56.210 1.00 76.31  ?  410 THR B C   1 
ATOM   6830 O  O   . THR B 1 410 ? -84.587 -17.341 -55.815 1.00 76.63  ?  410 THR B O   1 
ATOM   6831 C  CB  . THR B 1 410 ? -85.692 -14.718 -57.497 1.00 80.02  ?  410 THR B CB  1 
ATOM   6832 O  OG1 . THR B 1 410 ? -86.274 -13.416 -57.426 1.00 86.57  ?  410 THR B OG1 1 
ATOM   6833 C  CG2 . THR B 1 410 ? -86.742 -15.725 -57.911 1.00 80.55  ?  410 THR B CG2 1 
ATOM   6834 N  N   . ALA B 1 411 ? -82.924 -16.074 -56.719 1.00 72.65  ?  411 ALA B N   1 
ATOM   6835 C  CA  . ALA B 1 411 ? -81.940 -17.163 -56.920 1.00 72.86  ?  411 ALA B CA  1 
ATOM   6836 C  C   . ALA B 1 411 ? -80.525 -16.658 -56.617 1.00 69.70  ?  411 ALA B C   1 
ATOM   6837 O  O   . ALA B 1 411 ? -79.881 -16.098 -57.525 1.00 76.30  ?  411 ALA B O   1 
ATOM   6838 C  CB  . ALA B 1 411 ? -82.052 -17.696 -58.328 1.00 76.24  ?  411 ALA B CB  1 
ATOM   6839 N  N   . ALA B 1 412 ? -80.071 -16.853 -55.379 1.00 65.39  ?  412 ALA B N   1 
ATOM   6840 C  CA  . ALA B 1 412 ? -78.708 -16.513 -54.909 1.00 65.31  ?  412 ALA B CA  1 
ATOM   6841 C  C   . ALA B 1 412 ? -77.786 -17.725 -55.085 1.00 65.12  ?  412 ALA B C   1 
ATOM   6842 O  O   . ALA B 1 412 ? -76.641 -17.534 -55.534 1.00 66.37  ?  412 ALA B O   1 
ATOM   6843 C  CB  . ALA B 1 412 ? -78.751 -16.060 -53.470 1.00 65.23  ?  412 ALA B CB  1 
ATOM   6844 N  N   . GLY B 1 413 ? -78.272 -18.917 -54.724 1.00 63.22  ?  413 GLY B N   1 
ATOM   6845 C  CA  . GLY B 1 413 ? -77.526 -20.186 -54.820 1.00 61.56  ?  413 GLY B CA  1 
ATOM   6846 C  C   . GLY B 1 413 ? -78.017 -21.035 -55.977 1.00 61.72  ?  413 GLY B C   1 
ATOM   6847 O  O   . GLY B 1 413 ? -79.215 -20.942 -56.311 1.00 63.82  ?  413 GLY B O   1 
ATOM   6848 N  N   . MET B 1 414 ? -77.126 -21.837 -56.566 1.00 61.44  ?  414 MET B N   1 
ATOM   6849 C  CA  . MET B 1 414 ? -77.452 -22.762 -57.683 1.00 62.21  ?  414 MET B CA  1 
ATOM   6850 C  C   . MET B 1 414 ? -76.627 -24.047 -57.553 1.00 62.43  ?  414 MET B C   1 
ATOM   6851 O  O   . MET B 1 414 ? -75.416 -23.949 -57.275 1.00 67.28  ?  414 MET B O   1 
ATOM   6852 C  CB  . MET B 1 414 ? -77.164 -22.117 -59.041 1.00 62.79  ?  414 MET B CB  1 
ATOM   6853 C  CG  . MET B 1 414 ? -77.472 -23.030 -60.214 1.00 65.76  ?  414 MET B CG  1 
ATOM   6854 S  SD  . MET B 1 414 ? -77.217 -22.226 -61.812 1.00 69.50  ?  414 MET B SD  1 
ATOM   6855 C  CE  . MET B 1 414 ? -75.432 -22.068 -61.804 1.00 69.41  ?  414 MET B CE  1 
ATOM   6856 N  N   . LEU B 1 415 ? -77.275 -25.197 -57.757 1.00 57.69  ?  415 LEU B N   1 
ATOM   6857 C  CA  . LEU B 1 415 ? -76.626 -26.517 -57.959 1.00 55.19  ?  415 LEU B CA  1 
ATOM   6858 C  C   . LEU B 1 415 ? -77.031 -27.035 -59.343 1.00 54.59  ?  415 LEU B C   1 
ATOM   6859 O  O   . LEU B 1 415 ? -78.241 -27.074 -59.630 1.00 53.44  ?  415 LEU B O   1 
ATOM   6860 C  CB  . LEU B 1 415 ? -77.067 -27.468 -56.843 1.00 56.74  ?  415 LEU B CB  1 
ATOM   6861 C  CG  . LEU B 1 415 ? -76.374 -28.832 -56.815 1.00 58.66  ?  415 LEU B CG  1 
ATOM   6862 C  CD1 . LEU B 1 415 ? -76.389 -29.421 -55.411 1.00 58.85  ?  415 LEU B CD1 1 
ATOM   6863 C  CD2 . LEU B 1 415 ? -77.013 -29.801 -57.800 1.00 59.15  ?  415 LEU B CD2 1 
ATOM   6864 N  N   . ALA B 1 416 ? -76.051 -27.410 -60.167 1.00 54.33  ?  416 ALA B N   1 
ATOM   6865 C  CA  . ALA B 1 416 ? -76.253 -27.893 -61.553 1.00 54.97  ?  416 ALA B CA  1 
ATOM   6866 C  C   . ALA B 1 416 ? -75.895 -29.379 -61.636 1.00 56.17  ?  416 ALA B C   1 
ATOM   6867 O  O   . ALA B 1 416 ? -74.813 -29.756 -61.155 1.00 56.81  ?  416 ALA B O   1 
ATOM   6868 C  CB  . ALA B 1 416 ? -75.429 -27.078 -62.514 1.00 55.04  ?  416 ALA B CB  1 
ATOM   6869 N  N   . ILE B 1 417 ? -76.791 -30.180 -62.214 1.00 57.20  ?  417 ILE B N   1 
ATOM   6870 C  CA  . ILE B 1 417 ? -76.584 -31.632 -62.489 1.00 58.84  ?  417 ILE B CA  1 
ATOM   6871 C  C   . ILE B 1 417 ? -76.618 -31.819 -64.002 1.00 61.12  ?  417 ILE B C   1 
ATOM   6872 O  O   . ILE B 1 417 ? -77.639 -31.543 -64.625 1.00 60.23  ?  417 ILE B O   1 
ATOM   6873 C  CB  . ILE B 1 417 ? -77.645 -32.499 -61.779 1.00 57.35  ?  417 ILE B CB  1 
ATOM   6874 C  CG1 . ILE B 1 417 ? -77.790 -32.136 -60.298 1.00 56.52  ?  417 ILE B CG1 1 
ATOM   6875 C  CG2 . ILE B 1 417 ? -77.336 -33.977 -61.968 1.00 57.09  ?  417 ILE B CG2 1 
ATOM   6876 C  CD1 . ILE B 1 417 ? -78.681 -33.077 -59.513 1.00 56.35  ?  417 ILE B CD1 1 
ATOM   6877 N  N   . PRO B 1 418 ? -75.514 -32.277 -64.639 1.00 64.30  ?  418 PRO B N   1 
ATOM   6878 C  CA  . PRO B 1 418 ? -75.553 -32.697 -66.040 1.00 65.10  ?  418 PRO B CA  1 
ATOM   6879 C  C   . PRO B 1 418 ? -76.457 -33.929 -66.177 1.00 66.26  ?  418 PRO B C   1 
ATOM   6880 O  O   . PRO B 1 418 ? -76.387 -34.775 -65.309 1.00 69.53  ?  418 PRO B O   1 
ATOM   6881 C  CB  . PRO B 1 418 ? -74.101 -33.060 -66.384 1.00 65.43  ?  418 PRO B CB  1 
ATOM   6882 C  CG  . PRO B 1 418 ? -73.269 -32.452 -65.269 1.00 65.00  ?  418 PRO B CG  1 
ATOM   6883 C  CD  . PRO B 1 418 ? -74.171 -32.411 -64.055 1.00 64.19  ?  418 PRO B CD  1 
ATOM   6884 N  N   . ILE B 1 419 ? -77.279 -33.998 -67.226 1.00 67.68  ?  419 ILE B N   1 
ATOM   6885 C  CA  . ILE B 1 419 ? -78.240 -35.126 -67.424 1.00 73.79  ?  419 ILE B CA  1 
ATOM   6886 C  C   . ILE B 1 419 ? -77.939 -35.853 -68.742 1.00 78.55  ?  419 ILE B C   1 
ATOM   6887 O  O   . ILE B 1 419 ? -78.752 -36.712 -69.143 1.00 79.89  ?  419 ILE B O   1 
ATOM   6888 C  CB  . ILE B 1 419 ? -79.695 -34.625 -67.332 1.00 75.51  ?  419 ILE B CB  1 
ATOM   6889 C  CG1 . ILE B 1 419 ? -80.037 -33.593 -68.409 1.00 75.58  ?  419 ILE B CG1 1 
ATOM   6890 C  CG2 . ILE B 1 419 ? -79.972 -34.089 -65.937 1.00 76.01  ?  419 ILE B CG2 1 
ATOM   6891 C  CD1 . ILE B 1 419 ? -81.508 -33.264 -68.486 1.00 76.17  ?  419 ILE B CD1 1 
ATOM   6892 N  N   . SER B 1 420 ? -76.800 -35.546 -69.369 1.00 83.10  ?  420 SER B N   1 
ATOM   6893 C  CA  . SER B 1 420 ? -76.330 -36.193 -70.625 1.00 88.33  ?  420 SER B CA  1 
ATOM   6894 C  C   . SER B 1 420 ? -74.799 -36.236 -70.656 1.00 93.72  ?  420 SER B C   1 
ATOM   6895 O  O   . SER B 1 420 ? -74.164 -35.255 -70.207 1.00 87.52  ?  420 SER B O   1 
ATOM   6896 C  CB  . SER B 1 420 ? -76.896 -35.493 -71.837 1.00 90.24  ?  420 SER B CB  1 
ATOM   6897 O  OG  . SER B 1 420 ? -75.948 -35.444 -72.893 1.00 93.18  ?  420 SER B OG  1 
ATOM   6898 N  N   . GLN B 1 421 ? -74.247 -37.339 -71.173 1.00 99.63  ?  421 GLN B N   1 
ATOM   6899 C  CA  . GLN B 1 421 ? -72.784 -37.574 -71.318 1.00 105.30 ?  421 GLN B CA  1 
ATOM   6900 C  C   . GLN B 1 421 ? -72.228 -36.652 -72.413 1.00 107.08 ?  421 GLN B C   1 
ATOM   6901 O  O   . GLN B 1 421 ? -71.056 -36.241 -72.292 1.00 108.65 ?  421 GLN B O   1 
ATOM   6902 C  CB  . GLN B 1 421 ? -72.520 -39.051 -71.627 1.00 107.20 ?  421 GLN B CB  1 
ATOM   6903 C  CG  . GLN B 1 421 ? -71.053 -39.460 -71.551 1.00 109.44 ?  421 GLN B CG  1 
ATOM   6904 C  CD  . GLN B 1 421 ? -70.523 -39.565 -70.140 1.00 113.70 ?  421 GLN B CD  1 
ATOM   6905 O  OE1 . GLN B 1 421 ? -71.122 -39.077 -69.184 1.00 111.41 ?  421 GLN B OE1 1 
ATOM   6906 N  NE2 . GLN B 1 421 ? -69.377 -40.210 -69.996 1.00 118.91 ?  421 GLN B NE2 1 
ATOM   6907 N  N   . VAL B 1 422 ? -73.046 -36.327 -73.422 1.00 107.66 ?  422 VAL B N   1 
ATOM   6908 C  CA  . VAL B 1 422 ? -72.641 -35.560 -74.641 1.00 108.32 ?  422 VAL B CA  1 
ATOM   6909 C  C   . VAL B 1 422 ? -73.122 -34.108 -74.513 1.00 103.93 ?  422 VAL B C   1 
ATOM   6910 O  O   . VAL B 1 422 ? -72.289 -33.243 -74.177 1.00 102.22 ?  422 VAL B O   1 
ATOM   6911 C  CB  . VAL B 1 422 ? -73.179 -36.230 -75.923 1.00 113.93 ?  422 VAL B CB  1 
ATOM   6912 C  CG1 . VAL B 1 422 ? -72.900 -35.398 -77.169 1.00 115.75 ?  422 VAL B CG1 1 
ATOM   6913 C  CG2 . VAL B 1 422 ? -72.632 -37.641 -76.088 1.00 115.80 ?  422 VAL B CG2 1 
ATOM   6914 N  N   . LYS B 1 423 ? -74.414 -33.863 -74.770 1.00 99.09  ?  423 LYS B N   1 
ATOM   6915 C  CA  . LYS B 1 423 ? -75.018 -32.506 -74.901 1.00 94.23  ?  423 LYS B CA  1 
ATOM   6916 C  C   . LYS B 1 423 ? -74.963 -31.781 -73.552 1.00 89.65  ?  423 LYS B C   1 
ATOM   6917 O  O   . LYS B 1 423 ? -74.874 -32.466 -72.509 1.00 87.08  ?  423 LYS B O   1 
ATOM   6918 C  CB  . LYS B 1 423 ? -76.461 -32.604 -75.409 1.00 89.88  ?  423 LYS B CB  1 
ATOM   6919 N  N   . SER B 1 424 ? -75.012 -30.445 -73.587 1.00 84.84  ?  424 SER B N   1 
ATOM   6920 C  CA  . SER B 1 424 ? -74.967 -29.561 -72.385 1.00 84.02  ?  424 SER B CA  1 
ATOM   6921 C  C   . SER B 1 424 ? -76.391 -29.298 -71.868 1.00 80.94  ?  424 SER B C   1 
ATOM   6922 O  O   . SER B 1 424 ? -76.814 -28.119 -71.818 1.00 78.09  ?  424 SER B O   1 
ATOM   6923 C  CB  . SER B 1 424 ? -74.212 -28.284 -72.672 1.00 84.45  ?  424 SER B CB  1 
ATOM   6924 O  OG  . SER B 1 424 ? -74.948 -27.430 -73.535 1.00 87.73  ?  424 SER B OG  1 
ATOM   6925 N  N   . ASP B 1 425 ? -77.097 -30.371 -71.496 1.00 74.16  ?  425 ASP B N   1 
ATOM   6926 C  CA  . ASP B 1 425 ? -78.424 -30.332 -70.828 1.00 71.57  ?  425 ASP B CA  1 
ATOM   6927 C  C   . ASP B 1 425 ? -78.202 -30.458 -69.317 1.00 71.47  ?  425 ASP B C   1 
ATOM   6928 O  O   . ASP B 1 425 ? -77.386 -31.314 -68.911 1.00 71.16  ?  425 ASP B O   1 
ATOM   6929 C  CB  . ASP B 1 425 ? -79.345 -31.443 -71.338 1.00 70.48  ?  425 ASP B CB  1 
ATOM   6930 C  CG  . ASP B 1 425 ? -79.665 -31.358 -72.820 1.00 69.72  ?  425 ASP B CG  1 
ATOM   6931 O  OD1 . ASP B 1 425 ? -79.668 -30.232 -73.358 1.00 69.63  ?  425 ASP B OD1 1 
ATOM   6932 O  OD2 . ASP B 1 425 ? -79.918 -32.421 -73.423 1.00 68.60  -1 425 ASP B OD2 1 
ATOM   6933 N  N   . TYR B 1 426 ? -78.913 -29.647 -68.528 1.00 69.48  ?  426 TYR B N   1 
ATOM   6934 C  CA  . TYR B 1 426 ? -78.711 -29.501 -67.063 1.00 70.41  ?  426 TYR B CA  1 
ATOM   6935 C  C   . TYR B 1 426 ? -80.053 -29.536 -66.324 1.00 68.54  ?  426 TYR B C   1 
ATOM   6936 O  O   . TYR B 1 426 ? -81.068 -29.052 -66.857 1.00 68.07  ?  426 TYR B O   1 
ATOM   6937 C  CB  . TYR B 1 426 ? -77.927 -28.219 -66.766 1.00 73.08  ?  426 TYR B CB  1 
ATOM   6938 C  CG  . TYR B 1 426 ? -76.502 -28.270 -67.253 1.00 77.59  ?  426 TYR B CG  1 
ATOM   6939 C  CD1 . TYR B 1 426 ? -75.532 -28.951 -66.535 1.00 80.43  ?  426 TYR B CD1 1 
ATOM   6940 C  CD2 . TYR B 1 426 ? -76.130 -27.682 -68.450 1.00 79.87  ?  426 TYR B CD2 1 
ATOM   6941 C  CE1 . TYR B 1 426 ? -74.223 -29.028 -66.981 1.00 82.10  ?  426 TYR B CE1 1 
ATOM   6942 C  CE2 . TYR B 1 426 ? -74.824 -27.748 -68.911 1.00 81.45  ?  426 TYR B CE2 1 
ATOM   6943 C  CZ  . TYR B 1 426 ? -73.867 -28.426 -68.175 1.00 84.07  ?  426 TYR B CZ  1 
ATOM   6944 O  OH  . TYR B 1 426 ? -72.576 -28.503 -68.613 1.00 85.54  ?  426 TYR B OH  1 
ATOM   6945 N  N   . LEU B 1 427 ? -80.036 -30.124 -65.126 1.00 65.01  ?  427 LEU B N   1 
ATOM   6946 C  CA  . LEU B 1 427 ? -81.091 -29.989 -64.091 1.00 63.53  ?  427 LEU B CA  1 
ATOM   6947 C  C   . LEU B 1 427 ? -80.572 -28.993 -63.048 1.00 62.18  ?  427 LEU B C   1 
ATOM   6948 O  O   . LEU B 1 427 ? -79.518 -29.268 -62.454 1.00 64.02  ?  427 LEU B O   1 
ATOM   6949 C  CB  . LEU B 1 427 ? -81.371 -31.370 -63.488 1.00 63.31  ?  427 LEU B CB  1 
ATOM   6950 C  CG  . LEU B 1 427 ? -82.595 -31.474 -62.579 1.00 64.26  ?  427 LEU B CG  1 
ATOM   6951 C  CD1 . LEU B 1 427 ? -83.884 -31.306 -63.369 1.00 64.65  ?  427 LEU B CD1 1 
ATOM   6952 C  CD2 . LEU B 1 427 ? -82.599 -32.803 -61.843 1.00 65.67  ?  427 LEU B CD2 1 
ATOM   6953 N  N   . LEU B 1 428 ? -81.258 -27.861 -62.871 1.00 60.77  ?  428 LEU B N   1 
ATOM   6954 C  CA  . LEU B 1 428 ? -80.764 -26.711 -62.067 1.00 61.17  ?  428 LEU B CA  1 
ATOM   6955 C  C   . LEU B 1 428 ? -81.646 -26.525 -60.829 1.00 58.37  ?  428 LEU B C   1 
ATOM   6956 O  O   . LEU B 1 428 ? -82.856 -26.314 -60.995 1.00 60.66  ?  428 LEU B O   1 
ATOM   6957 C  CB  . LEU B 1 428 ? -80.759 -25.447 -62.934 1.00 62.84  ?  428 LEU B CB  1 
ATOM   6958 C  CG  . LEU B 1 428 ? -79.822 -25.474 -64.141 1.00 65.65  ?  428 LEU B CG  1 
ATOM   6959 C  CD1 . LEU B 1 428 ? -80.016 -24.239 -65.004 1.00 68.69  ?  428 LEU B CD1 1 
ATOM   6960 C  CD2 . LEU B 1 428 ? -78.369 -25.585 -63.708 1.00 66.82  ?  428 LEU B CD2 1 
ATOM   6961 N  N   . PHE B 1 429 ? -81.039 -26.599 -59.643 1.00 54.93  ?  429 PHE B N   1 
ATOM   6962 C  CA  . PHE B 1 429 ? -81.684 -26.339 -58.331 1.00 55.12  ?  429 PHE B CA  1 
ATOM   6963 C  C   . PHE B 1 429 ? -81.259 -24.954 -57.857 1.00 55.95  ?  429 PHE B C   1 
ATOM   6964 O  O   . PHE B 1 429 ? -80.073 -24.629 -57.993 1.00 61.18  ?  429 PHE B O   1 
ATOM   6965 C  CB  . PHE B 1 429 ? -81.286 -27.397 -57.302 1.00 54.89  ?  429 PHE B CB  1 
ATOM   6966 C  CG  . PHE B 1 429 ? -81.662 -28.803 -57.689 1.00 53.28  ?  429 PHE B CG  1 
ATOM   6967 C  CD1 . PHE B 1 429 ? -80.883 -29.523 -58.578 1.00 52.21  ?  429 PHE B CD1 1 
ATOM   6968 C  CD2 . PHE B 1 429 ? -82.800 -29.398 -57.173 1.00 51.85  ?  429 PHE B CD2 1 
ATOM   6969 C  CE1 . PHE B 1 429 ? -81.235 -30.811 -58.942 1.00 52.49  ?  429 PHE B CE1 1 
ATOM   6970 C  CE2 . PHE B 1 429 ? -83.145 -30.689 -57.532 1.00 51.81  ?  429 PHE B CE2 1 
ATOM   6971 C  CZ  . PHE B 1 429 ? -82.364 -31.393 -58.417 1.00 51.87  ?  429 PHE B CZ  1 
ATOM   6972 N  N   . PHE B 1 430 ? -82.194 -24.173 -57.318 1.00 55.09  ?  430 PHE B N   1 
ATOM   6973 C  CA  . PHE B 1 430 ? -81.946 -22.775 -56.889 1.00 55.51  ?  430 PHE B CA  1 
ATOM   6974 C  C   . PHE B 1 430 ? -82.365 -22.603 -55.430 1.00 57.74  ?  430 PHE B C   1 
ATOM   6975 O  O   . PHE B 1 430 ? -83.319 -23.271 -54.983 1.00 56.10  ?  430 PHE B O   1 
ATOM   6976 C  CB  . PHE B 1 430 ? -82.677 -21.795 -57.808 1.00 55.81  ?  430 PHE B CB  1 
ATOM   6977 C  CG  . PHE B 1 430 ? -82.208 -21.827 -59.240 1.00 54.70  ?  430 PHE B CG  1 
ATOM   6978 C  CD1 . PHE B 1 430 ? -81.044 -21.177 -59.620 1.00 55.22  ?  430 PHE B CD1 1 
ATOM   6979 C  CD2 . PHE B 1 430 ? -82.924 -22.517 -60.204 1.00 55.26  ?  430 PHE B CD2 1 
ATOM   6980 C  CE1 . PHE B 1 430 ? -80.611 -21.210 -60.937 1.00 56.89  ?  430 PHE B CE1 1 
ATOM   6981 C  CE2 . PHE B 1 430 ? -82.490 -22.552 -61.520 1.00 56.70  ?  430 PHE B CE2 1 
ATOM   6982 C  CZ  . PHE B 1 430 ? -81.334 -21.899 -61.885 1.00 57.17  ?  430 PHE B CZ  1 
ATOM   6983 N  N   . ARG B 1 431 ? -81.645 -21.738 -54.714 1.00 59.63  ?  431 ARG B N   1 
ATOM   6984 C  CA  . ARG B 1 431 ? -82.019 -21.283 -53.349 1.00 60.63  ?  431 ARG B CA  1 
ATOM   6985 C  C   . ARG B 1 431 ? -82.032 -19.756 -53.333 1.00 61.80  ?  431 ARG B C   1 
ATOM   6986 O  O   . ARG B 1 431 ? -81.116 -19.155 -53.922 1.00 59.79  ?  431 ARG B O   1 
ATOM   6987 C  CB  . ARG B 1 431 ? -81.059 -21.851 -52.301 1.00 60.14  ?  431 ARG B CB  1 
ATOM   6988 C  CG  . ARG B 1 431 ? -81.323 -23.308 -51.957 1.00 59.28  ?  431 ARG B CG  1 
ATOM   6989 C  CD  . ARG B 1 431 ? -80.275 -23.876 -51.023 1.00 59.69  ?  431 ARG B CD  1 
ATOM   6990 N  NE  . ARG B 1 431 ? -80.479 -25.301 -50.810 1.00 60.98  ?  431 ARG B NE  1 
ATOM   6991 C  CZ  . ARG B 1 431 ? -79.735 -26.075 -50.027 1.00 60.05  ?  431 ARG B CZ  1 
ATOM   6992 N  NH1 . ARG B 1 431 ? -78.709 -25.572 -49.360 1.00 60.84  ?  431 ARG B NH1 1 
ATOM   6993 N  NH2 . ARG B 1 431 ? -80.024 -27.360 -49.921 1.00 60.04  ?  431 ARG B NH2 1 
ATOM   6994 N  N   . LYS B 1 432 ? -83.049 -19.178 -52.690 1.00 66.32  ?  432 LYS B N   1 
ATOM   6995 C  CA  . LYS B 1 432 ? -83.220 -17.712 -52.505 1.00 69.85  ?  432 LYS B CA  1 
ATOM   6996 C  C   . LYS B 1 432 ? -82.098 -17.190 -51.605 1.00 71.35  ?  432 LYS B C   1 
ATOM   6997 O  O   . LYS B 1 432 ? -81.469 -18.006 -50.902 1.00 71.62  ?  432 LYS B O   1 
ATOM   6998 C  CB  . LYS B 1 432 ? -84.598 -17.395 -51.907 1.00 72.76  ?  432 LYS B CB  1 
ATOM   6999 C  CG  . LYS B 1 432 ? -85.750 -17.426 -52.905 1.00 75.59  ?  432 LYS B CG  1 
ATOM   7000 C  CD  . LYS B 1 432 ? -87.086 -16.998 -52.341 1.00 78.55  ?  432 LYS B CD  1 
ATOM   7001 C  CE  . LYS B 1 432 ? -87.811 -18.102 -51.603 1.00 82.10  ?  432 LYS B CE  1 
ATOM   7002 N  NZ  . LYS B 1 432 ? -89.235 -17.758 -51.378 1.00 85.39  ?  432 LYS B NZ  1 
ATOM   7003 N  N   . GLU B 1 433 ? -81.853 -15.878 -51.656 1.00 75.41  ?  433 GLU B N   1 
ATOM   7004 C  CA  . GLU B 1 433 ? -81.008 -15.139 -50.681 1.00 77.18  ?  433 GLU B CA  1 
ATOM   7005 C  C   . GLU B 1 433 ? -81.448 -15.559 -49.273 1.00 73.75  ?  433 GLU B C   1 
ATOM   7006 O  O   . GLU B 1 433 ? -82.670 -15.611 -49.029 1.00 69.46  ?  433 GLU B O   1 
ATOM   7007 C  CB  . GLU B 1 433 ? -81.151 -13.633 -50.911 1.00 85.40  ?  433 GLU B CB  1 
ATOM   7008 C  CG  . GLU B 1 433 ? -80.087 -12.793 -50.228 1.00 92.05  ?  433 GLU B CG  1 
ATOM   7009 C  CD  . GLU B 1 433 ? -80.255 -11.295 -50.423 1.00 95.30  ?  433 GLU B CD  1 
ATOM   7010 O  OE1 . GLU B 1 433 ? -81.102 -10.895 -51.250 1.00 95.37  ?  433 GLU B OE1 1 
ATOM   7011 O  OE2 . GLU B 1 433 ? -79.536 -10.531 -49.748 1.00 106.12 -1 433 GLU B OE2 1 
ATOM   7012 N  N   . ILE B 1 434 ? -80.493 -15.872 -48.394 1.00 72.80  ?  434 ILE B N   1 
ATOM   7013 C  CA  . ILE B 1 434 ? -80.753 -16.492 -47.058 1.00 74.05  ?  434 ILE B CA  1 
ATOM   7014 C  C   . ILE B 1 434 ? -81.623 -15.569 -46.189 1.00 75.88  ?  434 ILE B C   1 
ATOM   7015 O  O   . ILE B 1 434 ? -82.328 -16.102 -45.313 1.00 78.01  ?  434 ILE B O   1 
ATOM   7016 C  CB  . ILE B 1 434 ? -79.436 -16.887 -46.357 1.00 73.45  ?  434 ILE B CB  1 
ATOM   7017 C  CG1 . ILE B 1 434 ? -79.702 -17.702 -45.089 1.00 74.31  ?  434 ILE B CG1 1 
ATOM   7018 C  CG2 . ILE B 1 434 ? -78.571 -15.669 -46.070 1.00 73.85  ?  434 ILE B CG2 1 
ATOM   7019 C  CD1 . ILE B 1 434 ? -78.504 -18.472 -44.591 1.00 76.97  ?  434 ILE B CD1 1 
ATOM   7020 N  N   . VAL B 1 435 ? -81.578 -14.251 -46.409 1.00 79.93  ?  435 VAL B N   1 
ATOM   7021 C  CA  . VAL B 1 435 ? -82.355 -13.244 -45.615 1.00 82.27  ?  435 VAL B CA  1 
ATOM   7022 C  C   . VAL B 1 435 ? -83.856 -13.412 -45.886 1.00 83.42  ?  435 VAL B C   1 
ATOM   7023 O  O   . VAL B 1 435 ? -84.646 -13.116 -44.970 1.00 85.62  ?  435 VAL B O   1 
ATOM   7024 C  CB  . VAL B 1 435 ? -81.903 -11.797 -45.892 1.00 82.54  ?  435 VAL B CB  1 
ATOM   7025 C  CG1 . VAL B 1 435 ? -80.463 -11.565 -45.462 1.00 83.28  ?  435 VAL B CG1 1 
ATOM   7026 C  CG2 . VAL B 1 435 ? -82.106 -11.392 -47.347 1.00 84.31  ?  435 VAL B CG2 1 
ATOM   7027 N  N   . GLN B 1 436 ? -84.232 -13.857 -47.091 1.00 85.39  ?  436 GLN B N   1 
ATOM   7028 C  CA  . GLN B 1 436 ? -85.651 -14.026 -47.516 1.00 90.83  ?  436 GLN B CA  1 
ATOM   7029 C  C   . GLN B 1 436 ? -86.311 -15.150 -46.707 1.00 93.74  ?  436 GLN B C   1 
ATOM   7030 O  O   . GLN B 1 436 ? -87.527 -15.054 -46.458 1.00 94.24  ?  436 GLN B O   1 
ATOM   7031 C  CB  . GLN B 1 436 ? -85.754 -14.340 -49.011 1.00 93.34  ?  436 GLN B CB  1 
ATOM   7032 C  CG  . GLN B 1 436 ? -85.123 -13.290 -49.916 1.00 98.22  ?  436 GLN B CG  1 
ATOM   7033 C  CD  . GLN B 1 436 ? -85.752 -11.925 -49.773 1.00 102.06 ?  436 GLN B CD  1 
ATOM   7034 O  OE1 . GLN B 1 436 ? -86.961 -11.795 -49.590 1.00 102.02 ?  436 GLN B OE1 1 
ATOM   7035 N  NE2 . GLN B 1 436 ? -84.930 -10.890 -49.865 1.00 102.54 ?  436 GLN B NE2 1 
ATOM   7036 N  N   . ASN B 1 437 ? -85.537 -16.166 -46.308 1.00 99.45  ?  437 ASN B N   1 
ATOM   7037 C  CA  . ASN B 1 437 ? -86.035 -17.397 -45.634 1.00 100.92 ?  437 ASN B CA  1 
ATOM   7038 C  C   . ASN B 1 437 ? -85.804 -17.304 -44.118 1.00 100.20 ?  437 ASN B C   1 
ATOM   7039 O  O   . ASN B 1 437 ? -85.672 -18.366 -43.479 1.00 102.55 ?  437 ASN B O   1 
ATOM   7040 C  CB  . ASN B 1 437 ? -85.380 -18.654 -46.220 1.00 102.12 ?  437 ASN B CB  1 
ATOM   7041 C  CG  . ASN B 1 437 ? -85.724 -18.892 -47.676 1.00 105.06 ?  437 ASN B CG  1 
ATOM   7042 O  OD1 . ASN B 1 437 ? -86.602 -18.237 -48.236 1.00 107.49 ?  437 ASN B OD1 1 
ATOM   7043 N  ND2 . ASN B 1 437 ? -85.041 -19.838 -48.300 1.00 106.20 ?  437 ASN B ND2 1 
ATOM   7044 N  N   . LEU B 1 438 ? -85.776 -16.090 -43.558 1.00 100.71 ?  438 LEU B N   1 
ATOM   7045 C  CA  . LEU B 1 438 ? -85.594 -15.860 -42.098 1.00 103.10 ?  438 LEU B CA  1 
ATOM   7046 C  C   . LEU B 1 438 ? -86.926 -16.090 -41.375 1.00 107.01 ?  438 LEU B C   1 
ATOM   7047 O  O   . LEU B 1 438 ? -87.944 -15.518 -41.812 1.00 107.47 ?  438 LEU B O   1 
ATOM   7048 C  CB  . LEU B 1 438 ? -85.077 -14.439 -41.846 1.00 101.33 ?  438 LEU B CB  1 
ATOM   7049 C  CG  . LEU B 1 438 ? -83.560 -14.263 -41.893 1.00 100.14 ?  438 LEU B CG  1 
ATOM   7050 C  CD1 . LEU B 1 438 ? -83.185 -12.793 -41.778 1.00 99.58  ?  438 LEU B CD1 1 
ATOM   7051 C  CD2 . LEU B 1 438 ? -82.877 -15.070 -40.798 1.00 98.71  ?  438 LEU B CD2 1 
ATOM   7052 N  N   . ASN B 1 439 ? -86.903 -16.898 -40.311 1.00 112.78 ?  439 ASN B N   1 
ATOM   7053 C  CA  . ASN B 1 439 ? -88.051 -17.124 -39.390 1.00 118.05 ?  439 ASN B CA  1 
ATOM   7054 C  C   . ASN B 1 439 ? -87.669 -16.547 -38.020 1.00 118.79 ?  439 ASN B C   1 
ATOM   7055 O  O   . ASN B 1 439 ? -87.506 -17.329 -37.060 1.00 115.58 ?  439 ASN B O   1 
ATOM   7056 C  CB  . ASN B 1 439 ? -88.449 -18.603 -39.347 1.00 121.96 ?  439 ASN B CB  1 
ATOM   7057 C  CG  . ASN B 1 439 ? -89.763 -18.856 -38.636 1.00 125.75 ?  439 ASN B CG  1 
ATOM   7058 O  OD1 . ASN B 1 439 ? -90.554 -17.940 -38.421 1.00 126.59 ?  439 ASN B OD1 1 
ATOM   7059 N  ND2 . ASN B 1 439 ? -90.008 -20.104 -38.270 1.00 127.56 ?  439 ASN B ND2 1 
ATOM   7060 N  N   . TRP B 1 440 ? -87.519 -15.220 -37.958 1.00 122.37 ?  440 TRP B N   1 
ATOM   7061 C  CA  . TRP B 1 440 ? -87.043 -14.460 -36.770 1.00 125.58 ?  440 TRP B CA  1 
ATOM   7062 C  C   . TRP B 1 440 ? -88.229 -14.111 -35.862 1.00 126.98 ?  440 TRP B C   1 
ATOM   7063 O  O   . TRP B 1 440 ? -89.147 -13.414 -36.334 1.00 125.86 ?  440 TRP B O   1 
ATOM   7064 C  CB  . TRP B 1 440 ? -86.277 -13.207 -37.211 1.00 128.86 ?  440 TRP B CB  1 
ATOM   7065 C  CG  . TRP B 1 440 ? -85.728 -12.403 -36.074 1.00 133.00 ?  440 TRP B CG  1 
ATOM   7066 C  CD1 . TRP B 1 440 ? -85.113 -12.883 -34.954 1.00 134.13 ?  440 TRP B CD1 1 
ATOM   7067 C  CD2 . TRP B 1 440 ? -85.730 -10.969 -35.947 1.00 135.88 ?  440 TRP B CD2 1 
ATOM   7068 N  NE1 . TRP B 1 440 ? -84.740 -11.851 -34.137 1.00 136.03 ?  440 TRP B NE1 1 
ATOM   7069 C  CE2 . TRP B 1 440 ? -85.103 -10.665 -34.719 1.00 138.03 ?  440 TRP B CE2 1 
ATOM   7070 C  CE3 . TRP B 1 440 ? -86.196 -9.917  -36.745 1.00 137.31 ?  440 TRP B CE3 1 
ATOM   7071 C  CZ2 . TRP B 1 440 ? -84.935 -9.353  -34.275 1.00 139.33 ?  440 TRP B CZ2 1 
ATOM   7072 C  CZ3 . TRP B 1 440 ? -86.029 -8.621  -36.305 1.00 138.82 ?  440 TRP B CZ3 1 
ATOM   7073 C  CH2 . TRP B 1 440 ? -85.406 -8.346  -35.087 1.00 139.67 ?  440 TRP B CH2 1 
ATOM   7074 N  N   . ALA B 1 441 ? -88.187 -14.568 -34.605 1.00 132.64 ?  441 ALA B N   1 
ATOM   7075 C  CA  . ALA B 1 441 ? -89.258 -14.407 -33.591 1.00 136.93 ?  441 ALA B CA  1 
ATOM   7076 C  C   . ALA B 1 441 ? -88.858 -13.348 -32.553 1.00 139.09 ?  441 ALA B C   1 
ATOM   7077 O  O   . ALA B 1 441 ? -89.421 -13.375 -31.440 1.00 141.02 ?  441 ALA B O   1 
ATOM   7078 C  CB  . ALA B 1 441 ? -89.544 -15.739 -32.937 1.00 136.16 ?  441 ALA B CB  1 
ATOM   7079 N  N   . GLY B 1 442 ? -87.942 -12.441 -32.914 1.00 141.52 ?  442 GLY B N   1 
ATOM   7080 C  CA  . GLY B 1 442 ? -87.405 -11.394 -32.022 1.00 143.66 ?  442 GLY B CA  1 
ATOM   7081 C  C   . GLY B 1 442 ? -88.092 -10.056 -32.239 1.00 145.62 ?  442 GLY B C   1 
ATOM   7082 O  O   . GLY B 1 442 ? -88.761 -9.895  -33.281 1.00 143.90 ?  442 GLY B O   1 
ATOM   7083 N  N   . ASN B 1 443 ? -87.924 -9.130  -31.288 1.00 149.78 ?  443 ASN B N   1 
ATOM   7084 C  CA  . ASN B 1 443 ? -88.530 -7.770  -31.304 1.00 152.65 ?  443 ASN B CA  1 
ATOM   7085 C  C   . ASN B 1 443 ? -87.558 -6.798  -31.973 1.00 153.06 ?  443 ASN B C   1 
ATOM   7086 O  O   . ASN B 1 443 ? -86.432 -6.636  -31.507 1.00 154.52 ?  443 ASN B O   1 
ATOM   7087 C  CB  . ASN B 1 443 ? -88.901 -7.315  -29.888 1.00 154.20 ?  443 ASN B CB  1 
ATOM   7088 C  CG  . ASN B 1 443 ? -89.817 -6.109  -29.861 1.00 156.45 ?  443 ASN B CG  1 
ATOM   7089 O  OD1 . ASN B 1 443 ? -89.495 -5.093  -29.248 1.00 157.30 ?  443 ASN B OD1 1 
ATOM   7090 N  ND2 . ASN B 1 443 ? -90.965 -6.210  -30.513 1.00 159.20 ?  443 ASN B ND2 1 
ATOM   7091 N  N   . PRO B 1 444 ? -87.949 -6.124  -33.083 1.00 153.13 ?  444 PRO B N   1 
ATOM   7092 C  CA  . PRO B 1 444 ? -87.066 -5.167  -33.755 1.00 153.09 ?  444 PRO B CA  1 
ATOM   7093 C  C   . PRO B 1 444 ? -86.981 -3.792  -33.071 1.00 152.07 ?  444 PRO B C   1 
ATOM   7094 O  O   . PRO B 1 444 ? -85.996 -3.103  -33.284 1.00 147.45 ?  444 PRO B O   1 
ATOM   7095 C  CB  . PRO B 1 444 ? -87.705 -5.036  -35.146 1.00 153.04 ?  444 PRO B CB  1 
ATOM   7096 C  CG  . PRO B 1 444 ? -89.184 -5.248  -34.893 1.00 153.06 ?  444 PRO B CG  1 
ATOM   7097 C  CD  . PRO B 1 444 ? -89.254 -6.247  -33.754 1.00 152.39 ?  444 PRO B CD  1 
ATOM   7098 N  N   . GLU B 1 445 ? -87.999 -3.432  -32.279 1.00 151.24 ?  445 GLU B N   1 
ATOM   7099 C  CA  . GLU B 1 445 ? -88.110 -2.126  -31.569 1.00 148.00 ?  445 GLU B CA  1 
ATOM   7100 C  C   . GLU B 1 445 ? -87.357 -2.176  -30.231 1.00 146.17 ?  445 GLU B C   1 
ATOM   7101 O  O   . GLU B 1 445 ? -87.212 -1.107  -29.606 1.00 148.34 ?  445 GLU B O   1 
ATOM   7102 C  CB  . GLU B 1 445 ? -89.580 -1.765  -31.343 1.00 143.13 ?  445 GLU B CB  1 
ATOM   7103 N  N   . LYS B 1 446 ? -86.906 -3.364  -29.806 1.00 141.09 ?  446 LYS B N   1 
ATOM   7104 C  CA  . LYS B 1 446 ? -86.102 -3.570  -28.568 1.00 134.21 ?  446 LYS B CA  1 
ATOM   7105 C  C   . LYS B 1 446 ? -84.708 -2.962  -28.766 1.00 132.34 ?  446 LYS B C   1 
ATOM   7106 O  O   . LYS B 1 446 ? -83.936 -3.507  -29.583 1.00 127.16 ?  446 LYS B O   1 
ATOM   7107 C  CB  . LYS B 1 446 ? -85.997 -5.059  -28.225 1.00 128.34 ?  446 LYS B CB  1 
ATOM   7108 N  N   . SER B 1 447 ? -84.419 -1.869  -28.051 1.00 129.41 ?  447 SER B N   1 
ATOM   7109 C  CA  . SER B 1 447 ? -83.112 -1.150  -28.059 1.00 122.06 ?  447 SER B CA  1 
ATOM   7110 C  C   . SER B 1 447 ? -82.304 -1.521  -26.807 1.00 117.96 ?  447 SER B C   1 
ATOM   7111 O  O   . SER B 1 447 ? -82.923 -1.720  -25.740 1.00 115.74 ?  447 SER B O   1 
ATOM   7112 C  CB  . SER B 1 447 ? -83.313 0.341   -28.163 1.00 118.99 ?  447 SER B CB  1 
ATOM   7113 N  N   . TYR B 1 448 ? -80.975 -1.607  -26.941 1.00 112.45 ?  448 TYR B N   1 
ATOM   7114 C  CA  . TYR B 1 448 ? -80.028 -2.033  -25.873 1.00 108.80 ?  448 TYR B CA  1 
ATOM   7115 C  C   . TYR B 1 448 ? -79.201 -0.838  -25.384 1.00 106.39 ?  448 TYR B C   1 
ATOM   7116 O  O   . TYR B 1 448 ? -78.812 0.013   -26.208 1.00 103.18 ?  448 TYR B O   1 
ATOM   7117 C  CB  . TYR B 1 448 ? -79.109 -3.147  -26.384 1.00 109.56 ?  448 TYR B CB  1 
ATOM   7118 C  CG  . TYR B 1 448 ? -79.813 -4.440  -26.713 1.00 107.82 ?  448 TYR B CG  1 
ATOM   7119 C  CD1 . TYR B 1 448 ? -80.095 -5.372  -25.726 1.00 105.39 ?  448 TYR B CD1 1 
ATOM   7120 C  CD2 . TYR B 1 448 ? -80.205 -4.732  -28.011 1.00 105.10 ?  448 TYR B CD2 1 
ATOM   7121 C  CE1 . TYR B 1 448 ? -80.747 -6.559  -26.019 1.00 104.35 ?  448 TYR B CE1 1 
ATOM   7122 C  CE2 . TYR B 1 448 ? -80.859 -5.914  -28.320 1.00 102.64 ?  448 TYR B CE2 1 
ATOM   7123 C  CZ  . TYR B 1 448 ? -81.131 -6.831  -27.321 1.00 104.00 ?  448 TYR B CZ  1 
ATOM   7124 O  OH  . TYR B 1 448 ? -81.775 -7.997  -27.622 1.00 104.22 ?  448 TYR B OH  1 
ATOM   7125 N  N   . GLU B 1 449 ? -78.945 -0.784  -24.072 1.00 106.12 ?  449 GLU B N   1 
ATOM   7126 C  CA  . GLU B 1 449 ? -78.000 0.174   -23.437 1.00 104.99 ?  449 GLU B CA  1 
ATOM   7127 C  C   . GLU B 1 449 ? -76.576 -0.227  -23.839 1.00 104.38 ?  449 GLU B C   1 
ATOM   7128 O  O   . GLU B 1 449 ? -76.218 -1.400  -23.619 1.00 107.76 ?  449 GLU B O   1 
ATOM   7129 C  CB  . GLU B 1 449 ? -78.166 0.175   -21.915 1.00 101.51 ?  449 GLU B CB  1 
ATOM   7130 N  N   . THR B 1 450 ? -75.811 0.702   -24.422 1.00 98.93  ?  450 THR B N   1 
ATOM   7131 C  CA  . THR B 1 450 ? -74.411 0.472   -24.882 1.00 95.98  ?  450 THR B CA  1 
ATOM   7132 C  C   . THR B 1 450 ? -73.433 0.821   -23.753 1.00 94.92  ?  450 THR B C   1 
ATOM   7133 O  O   . THR B 1 450 ? -73.894 1.223   -22.668 1.00 93.00  ?  450 THR B O   1 
ATOM   7134 C  CB  . THR B 1 450 ? -74.098 1.272   -26.154 1.00 95.22  ?  450 THR B CB  1 
ATOM   7135 O  OG1 . THR B 1 450 ? -74.039 2.656   -25.811 1.00 94.49  ?  450 THR B OG1 1 
ATOM   7136 C  CG2 . THR B 1 450 ? -75.117 1.062   -27.252 1.00 96.35  ?  450 THR B CG2 1 
ATOM   7137 N  N   . GLY B 1 451 ? -72.132 0.651   -24.009 1.00 95.60  ?  451 GLY B N   1 
ATOM   7138 C  CA  . GLY B 1 451 ? -71.036 1.016   -23.090 1.00 94.13  ?  451 GLY B CA  1 
ATOM   7139 C  C   . GLY B 1 451 ? -69.916 1.741   -23.832 1.00 91.83  ?  451 GLY B C   1 
ATOM   7140 O  O   . GLY B 1 451 ? -70.141 2.280   -24.914 1.00 88.71  ?  451 GLY B O   1 
ATOM   7141 N  N   . PRO B 1 452 ? -68.684 1.779   -23.272 1.00 89.91  ?  452 PRO B N   1 
ATOM   7142 C  CA  . PRO B 1 452 ? -67.544 2.416   -23.937 1.00 88.70  ?  452 PRO B CA  1 
ATOM   7143 C  C   . PRO B 1 452 ? -67.340 2.014   -25.408 1.00 91.63  ?  452 PRO B C   1 
ATOM   7144 O  O   . PRO B 1 452 ? -67.124 2.895   -26.224 1.00 89.54  ?  452 PRO B O   1 
ATOM   7145 C  CB  . PRO B 1 452 ? -66.344 1.937   -23.103 1.00 88.63  ?  452 PRO B CB  1 
ATOM   7146 C  CG  . PRO B 1 452 ? -66.917 1.719   -21.718 1.00 89.50  ?  452 PRO B CG  1 
ATOM   7147 C  CD  . PRO B 1 452 ? -68.328 1.220   -21.956 1.00 89.80  ?  452 PRO B CD  1 
ATOM   7148 N  N   . MET B 1 453 ? -67.420 0.711   -25.705 1.00 94.21  ?  453 MET B N   1 
ATOM   7149 C  CA  . MET B 1 453 ? -67.041 0.118   -27.020 1.00 95.25  ?  453 MET B CA  1 
ATOM   7150 C  C   . MET B 1 453 ? -68.141 0.353   -28.067 1.00 92.39  ?  453 MET B C   1 
ATOM   7151 O  O   . MET B 1 453 ? -67.870 0.122   -29.262 1.00 88.15  ?  453 MET B O   1 
ATOM   7152 C  CB  . MET B 1 453 ? -66.774 -1.384  -26.883 1.00 100.14 ?  453 MET B CB  1 
ATOM   7153 C  CG  . MET B 1 453 ? -65.560 -1.705  -26.029 1.00 104.03 ?  453 MET B CG  1 
ATOM   7154 S  SD  . MET B 1 453 ? -64.003 -1.231  -26.825 1.00 110.01 ?  453 MET B SD  1 
ATOM   7155 C  CE  . MET B 1 453 ? -62.841 -1.600  -25.512 1.00 111.85 ?  453 MET B CE  1 
ATOM   7156 N  N   . GLY B 1 454 ? -69.331 0.786   -27.641 1.00 91.17  ?  454 GLY B N   1 
ATOM   7157 C  CA  . GLY B 1 454 ? -70.410 1.233   -28.544 1.00 90.68  ?  454 GLY B CA  1 
ATOM   7158 C  C   . GLY B 1 454 ? -71.458 0.159   -28.773 1.00 90.28  ?  454 GLY B C   1 
ATOM   7159 O  O   . GLY B 1 454 ? -71.508 -0.809  -27.982 1.00 87.50  ?  454 GLY B O   1 
ATOM   7160 N  N   . ASP B 1 455 ? -72.258 0.325   -29.830 1.00 90.03  ?  455 ASP B N   1 
ATOM   7161 C  CA  . ASP B 1 455 ? -73.461 -0.502  -30.123 1.00 92.92  ?  455 ASP B CA  1 
ATOM   7162 C  C   . ASP B 1 455 ? -73.062 -1.789  -30.860 1.00 91.21  ?  455 ASP B C   1 
ATOM   7163 O  O   . ASP B 1 455 ? -73.974 -2.570  -31.200 1.00 94.10  ?  455 ASP B O   1 
ATOM   7164 C  CB  . ASP B 1 455 ? -74.511 0.305   -30.897 1.00 96.20  ?  455 ASP B CB  1 
ATOM   7165 C  CG  . ASP B 1 455 ? -74.108 0.702   -32.309 1.00 99.15  ?  455 ASP B CG  1 
ATOM   7166 O  OD1 . ASP B 1 455 ? -72.888 0.748   -32.586 1.00 95.23  ?  455 ASP B OD1 1 
ATOM   7167 O  OD2 . ASP B 1 455 ? -75.021 0.969   -33.122 1.00 100.32 -1 455 ASP B OD2 1 
ATOM   7168 N  N   . ARG B 1 456 ? -71.763 -2.002  -31.106 1.00 84.45  ?  456 ARG B N   1 
ATOM   7169 C  CA  . ARG B 1 456 ? -71.231 -3.262  -31.701 1.00 78.11  ?  456 ARG B CA  1 
ATOM   7170 C  C   . ARG B 1 456 ? -71.528 -4.438  -30.762 1.00 73.64  ?  456 ARG B C   1 
ATOM   7171 O  O   . ARG B 1 456 ? -71.884 -5.520  -31.268 1.00 73.75  ?  456 ARG B O   1 
ATOM   7172 C  CB  . ARG B 1 456 ? -69.728 -3.154  -31.980 1.00 76.85  ?  456 ARG B CB  1 
ATOM   7173 C  CG  . ARG B 1 456 ? -69.073 -4.443  -32.464 1.00 76.49  ?  456 ARG B CG  1 
ATOM   7174 C  CD  . ARG B 1 456 ? -69.672 -4.978  -33.753 1.00 77.83  ?  456 ARG B CD  1 
ATOM   7175 N  NE  . ARG B 1 456 ? -69.043 -6.220  -34.192 1.00 77.54  ?  456 ARG B NE  1 
ATOM   7176 C  CZ  . ARG B 1 456 ? -69.384 -7.445  -33.792 1.00 75.65  ?  456 ARG B CZ  1 
ATOM   7177 N  NH1 . ARG B 1 456 ? -70.362 -7.629  -32.921 1.00 74.98  ?  456 ARG B NH1 1 
ATOM   7178 N  NH2 . ARG B 1 456 ? -68.733 -8.493  -34.268 1.00 77.04  ?  456 ARG B NH2 1 
ATOM   7179 N  N   . LEU B 1 457 ? -71.400 -4.230  -29.449 1.00 68.27  ?  457 LEU B N   1 
ATOM   7180 C  CA  . LEU B 1 457 ? -71.581 -5.291  -28.421 1.00 67.98  ?  457 LEU B CA  1 
ATOM   7181 C  C   . LEU B 1 457 ? -73.057 -5.373  -28.014 1.00 65.55  ?  457 LEU B C   1 
ATOM   7182 O  O   . LEU B 1 457 ? -73.354 -5.335  -26.797 1.00 65.32  ?  457 LEU B O   1 
ATOM   7183 C  CB  . LEU B 1 457 ? -70.670 -4.991  -27.227 1.00 68.34  ?  457 LEU B CB  1 
ATOM   7184 C  CG  . LEU B 1 457 ? -69.197 -4.778  -27.571 1.00 69.71  ?  457 LEU B CG  1 
ATOM   7185 C  CD1 . LEU B 1 457 ? -68.362 -4.704  -26.304 1.00 69.15  ?  457 LEU B CD1 1 
ATOM   7186 C  CD2 . LEU B 1 457 ? -68.676 -5.873  -28.495 1.00 69.49  ?  457 LEU B CD2 1 
ATOM   7187 N  N   . THR B 1 458 ? -73.941 -5.511  -29.005 1.00 63.74  ?  458 THR B N   1 
ATOM   7188 C  CA  . THR B 1 458 ? -75.408 -5.680  -28.815 1.00 64.81  ?  458 THR B CA  1 
ATOM   7189 C  C   . THR B 1 458 ? -75.928 -6.691  -29.831 1.00 65.85  ?  458 THR B C   1 
ATOM   7190 O  O   . THR B 1 458 ? -75.472 -6.707  -30.975 1.00 66.58  ?  458 THR B O   1 
ATOM   7191 C  CB  . THR B 1 458 ? -76.156 -4.348  -28.951 1.00 63.39  ?  458 THR B CB  1 
ATOM   7192 O  OG1 . THR B 1 458 ? -76.077 -3.962  -30.323 1.00 62.52  ?  458 THR B OG1 1 
ATOM   7193 C  CG2 . THR B 1 458 ? -75.598 -3.258  -28.061 1.00 64.62  ?  458 THR B CG2 1 
ATOM   7194 N  N   . PRO B 1 459 ? -76.892 -7.561  -29.449 1.00 65.90  ?  459 PRO B N   1 
ATOM   7195 C  CA  . PRO B 1 459 ? -77.524 -8.480  -30.397 1.00 66.28  ?  459 PRO B CA  1 
ATOM   7196 C  C   . PRO B 1 459 ? -77.984 -7.795  -31.693 1.00 69.98  ?  459 PRO B C   1 
ATOM   7197 O  O   . PRO B 1 459 ? -77.765 -8.357  -32.758 1.00 74.77  ?  459 PRO B O   1 
ATOM   7198 C  CB  . PRO B 1 459 ? -78.739 -9.004  -29.621 1.00 65.86  ?  459 PRO B CB  1 
ATOM   7199 C  CG  . PRO B 1 459 ? -78.304 -8.940  -28.172 1.00 67.44  ?  459 PRO B CG  1 
ATOM   7200 C  CD  . PRO B 1 459 ? -77.424 -7.710  -28.084 1.00 66.24  ?  459 PRO B CD  1 
ATOM   7201 N  N   . ARG B 1 460 ? -78.601 -6.614  -31.570 1.00 67.11  ?  460 ARG B N   1 
ATOM   7202 C  CA  . ARG B 1 460 ? -79.149 -5.849  -32.729 1.00 66.85  ?  460 ARG B CA  1 
ATOM   7203 C  C   . ARG B 1 460 ? -78.056 -5.667  -33.793 1.00 66.13  ?  460 ARG B C   1 
ATOM   7204 O  O   . ARG B 1 460 ? -78.314 -6.021  -34.958 1.00 69.05  ?  460 ARG B O   1 
ATOM   7205 C  CB  . ARG B 1 460 ? -79.724 -4.501  -32.283 1.00 68.15  ?  460 ARG B CB  1 
ATOM   7206 N  N   . LYS B 1 461 ? -76.883 -5.151  -33.410 1.00 66.70  ?  461 LYS B N   1 
ATOM   7207 C  CA  . LYS B 1 461 ? -75.778 -4.829  -34.360 1.00 67.83  ?  461 LYS B CA  1 
ATOM   7208 C  C   . LYS B 1 461 ? -75.106 -6.128  -34.827 1.00 67.81  ?  461 LYS B C   1 
ATOM   7209 O  O   . LYS B 1 461 ? -74.681 -6.180  -36.003 1.00 69.81  ?  461 LYS B O   1 
ATOM   7210 C  CB  . LYS B 1 461 ? -74.732 -3.899  -33.733 1.00 64.25  ?  461 LYS B CB  1 
ATOM   7211 N  N   . SER B 1 462 ? -75.006 -7.137  -33.953 1.00 63.80  ?  462 SER B N   1 
ATOM   7212 C  CA  . SER B 1 462 ? -74.479 -8.481  -34.315 1.00 65.55  ?  462 SER B CA  1 
ATOM   7213 C  C   . SER B 1 462 ? -75.259 -9.021  -35.523 1.00 66.02  ?  462 SER B C   1 
ATOM   7214 O  O   . SER B 1 462 ? -74.628 -9.328  -36.560 1.00 64.00  ?  462 SER B O   1 
ATOM   7215 C  CB  . SER B 1 462 ? -74.534 -9.436  -33.148 1.00 65.99  ?  462 SER B CB  1 
ATOM   7216 O  OG  . SER B 1 462 ? -73.513 -9.149  -32.203 1.00 63.22  ?  462 SER B OG  1 
ATOM   7217 N  N   . PHE B 1 463 ? -76.587 -9.093  -35.393 1.00 65.22  ?  463 PHE B N   1 
ATOM   7218 C  CA  . PHE B 1 463 ? -77.528 -9.595  -36.430 1.00 66.84  ?  463 PHE B CA  1 
ATOM   7219 C  C   . PHE B 1 463 ? -77.395 -8.744  -37.702 1.00 66.69  ?  463 PHE B C   1 
ATOM   7220 O  O   . PHE B 1 463 ? -77.322 -9.317  -38.808 1.00 66.70  ?  463 PHE B O   1 
ATOM   7221 C  CB  . PHE B 1 463 ? -78.953 -9.625  -35.868 1.00 69.08  ?  463 PHE B CB  1 
ATOM   7222 C  CG  . PHE B 1 463 ? -79.984 -10.346 -36.703 1.00 73.47  ?  463 PHE B CG  1 
ATOM   7223 C  CD1 . PHE B 1 463 ? -79.627 -11.327 -37.619 1.00 75.44  ?  463 PHE B CD1 1 
ATOM   7224 C  CD2 . PHE B 1 463 ? -81.333 -10.065 -36.540 1.00 77.04  ?  463 PHE B CD2 1 
ATOM   7225 C  CE1 . PHE B 1 463 ? -80.590 -11.982 -38.371 1.00 78.16  ?  463 PHE B CE1 1 
ATOM   7226 C  CE2 . PHE B 1 463 ? -82.295 -10.726 -37.287 1.00 78.27  ?  463 PHE B CE2 1 
ATOM   7227 C  CZ  . PHE B 1 463 ? -81.923 -11.685 -38.200 1.00 79.08  ?  463 PHE B CZ  1 
ATOM   7228 N  N   . ALA B 1 464 ? -77.334 -7.419  -37.544 1.00 66.97  ?  464 ALA B N   1 
ATOM   7229 C  CA  . ALA B 1 464 ? -77.167 -6.434  -38.643 1.00 65.55  ?  464 ALA B CA  1 
ATOM   7230 C  C   . ALA B 1 464 ? -75.901 -6.751  -39.453 1.00 64.88  ?  464 ALA B C   1 
ATOM   7231 O  O   . ALA B 1 464 ? -75.980 -6.726  -40.698 1.00 61.68  ?  464 ALA B O   1 
ATOM   7232 C  CB  . ALA B 1 464 ? -77.123 -5.036  -38.080 1.00 66.24  ?  464 ALA B CB  1 
ATOM   7233 N  N   . ILE B 1 465 ? -74.786 -7.043  -38.769 1.00 65.93  ?  465 ILE B N   1 
ATOM   7234 C  CA  . ILE B 1 465 ? -73.460 -7.355  -39.393 1.00 67.46  ?  465 ILE B CA  1 
ATOM   7235 C  C   . ILE B 1 465 ? -73.558 -8.683  -40.155 1.00 67.99  ?  465 ILE B C   1 
ATOM   7236 O  O   . ILE B 1 465 ? -73.069 -8.737  -41.306 1.00 64.27  ?  465 ILE B O   1 
ATOM   7237 C  CB  . ILE B 1 465 ? -72.330 -7.375  -38.341 1.00 68.27  ?  465 ILE B CB  1 
ATOM   7238 C  CG1 . ILE B 1 465 ? -72.003 -5.961  -37.852 1.00 69.59  ?  465 ILE B CG1 1 
ATOM   7239 C  CG2 . ILE B 1 465 ? -71.087 -8.080  -38.875 1.00 66.20  ?  465 ILE B CG2 1 
ATOM   7240 C  CD1 . ILE B 1 465 ? -71.214 -5.919  -36.563 1.00 72.17  ?  465 ILE B CD1 1 
ATOM   7241 N  N   . TRP B 1 466 ? -74.143 -9.715  -39.535 1.00 68.51  ?  466 TRP B N   1 
ATOM   7242 C  CA  . TRP B 1 466 ? -74.332 -11.049 -40.166 1.00 67.40  ?  466 TRP B CA  1 
ATOM   7243 C  C   . TRP B 1 466 ? -75.093 -10.886 -41.487 1.00 66.38  ?  466 TRP B C   1 
ATOM   7244 O  O   . TRP B 1 466 ? -74.577 -11.354 -42.515 1.00 64.16  ?  466 TRP B O   1 
ATOM   7245 C  CB  . TRP B 1 466 ? -75.047 -12.037 -39.235 1.00 68.14  ?  466 TRP B CB  1 
ATOM   7246 C  CG  . TRP B 1 466 ? -75.367 -13.326 -39.930 1.00 68.78  ?  466 TRP B CG  1 
ATOM   7247 C  CD1 . TRP B 1 466 ? -74.534 -14.392 -40.117 1.00 67.50  ?  466 TRP B CD1 1 
ATOM   7248 C  CD2 . TRP B 1 466 ? -76.598 -13.660 -40.596 1.00 67.98  ?  466 TRP B CD2 1 
ATOM   7249 N  NE1 . TRP B 1 466 ? -75.168 -15.373 -40.831 1.00 66.67  ?  466 TRP B NE1 1 
ATOM   7250 C  CE2 . TRP B 1 466 ? -76.435 -14.954 -41.137 1.00 66.10  ?  466 TRP B CE2 1 
ATOM   7251 C  CE3 . TRP B 1 466 ? -77.821 -13.001 -40.771 1.00 66.97  ?  466 TRP B CE3 1 
ATOM   7252 C  CZ2 . TRP B 1 466 ? -77.452 -15.596 -41.841 1.00 66.73  ?  466 TRP B CZ2 1 
ATOM   7253 C  CZ3 . TRP B 1 466 ? -78.825 -13.637 -41.467 1.00 67.84  ?  466 TRP B CZ3 1 
ATOM   7254 C  CH2 . TRP B 1 466 ? -78.641 -14.918 -41.992 1.00 68.53  ?  466 TRP B CH2 1 
ATOM   7255 N  N   . LYS B 1 467 ? -76.268 -10.244 -41.449 1.00 67.86  ?  467 LYS B N   1 
ATOM   7256 C  CA  . LYS B 1 467 ? -77.125 -9.977  -42.640 1.00 71.14  ?  467 LYS B CA  1 
ATOM   7257 C  C   . LYS B 1 467 ? -76.274 -9.393  -43.774 1.00 71.73  ?  467 LYS B C   1 
ATOM   7258 O  O   . LYS B 1 467 ? -76.476 -9.808  -44.933 1.00 75.09  ?  467 LYS B O   1 
ATOM   7259 C  CB  . LYS B 1 467 ? -78.266 -9.012  -42.303 1.00 72.99  ?  467 LYS B CB  1 
ATOM   7260 C  CG  . LYS B 1 467 ? -79.410 -9.615  -41.503 1.00 77.31  ?  467 LYS B CG  1 
ATOM   7261 C  CD  . LYS B 1 467 ? -80.570 -8.666  -41.307 1.00 80.58  ?  467 LYS B CD  1 
ATOM   7262 C  CE  . LYS B 1 467 ? -81.488 -9.090  -40.182 1.00 86.16  ?  467 LYS B CE  1 
ATOM   7263 N  NZ  . LYS B 1 467 ? -82.470 -8.032  -39.849 1.00 90.44  ?  467 LYS B NZ  1 
ATOM   7264 N  N   . GLU B 1 468 ? -75.367 -8.468  -43.443 1.00 71.11  ?  468 GLU B N   1 
ATOM   7265 C  CA  . GLU B 1 468 ? -74.467 -7.785  -44.412 1.00 69.61  ?  468 GLU B CA  1 
ATOM   7266 C  C   . GLU B 1 468 ? -73.511 -8.816  -45.027 1.00 69.45  ?  468 GLU B C   1 
ATOM   7267 O  O   . GLU B 1 468 ? -73.317 -8.777  -46.256 1.00 72.67  ?  468 GLU B O   1 
ATOM   7268 C  CB  . GLU B 1 468 ? -73.714 -6.642  -43.726 1.00 67.92  ?  468 GLU B CB  1 
ATOM   7269 N  N   . SER B 1 469 ? -72.954 -9.717  -44.210 1.00 69.10  ?  469 SER B N   1 
ATOM   7270 C  CA  . SER B 1 469 ? -71.945 -10.729 -44.634 1.00 70.33  ?  469 SER B CA  1 
ATOM   7271 C  C   . SER B 1 469 ? -72.567 -11.806 -45.538 1.00 71.38  ?  469 SER B C   1 
ATOM   7272 O  O   . SER B 1 469 ? -71.798 -12.458 -46.278 1.00 68.87  ?  469 SER B O   1 
ATOM   7273 C  CB  . SER B 1 469 ? -71.276 -11.349 -43.439 1.00 70.84  ?  469 SER B CB  1 
ATOM   7274 O  OG  . SER B 1 469 ? -72.226 -11.994 -42.608 1.00 72.96  ?  469 SER B OG  1 
ATOM   7275 N  N   . VAL B 1 470 ? -73.894 -11.983 -45.493 1.00 74.01  ?  470 VAL B N   1 
ATOM   7276 C  CA  . VAL B 1 470 ? -74.627 -13.067 -46.220 1.00 74.19  ?  470 VAL B CA  1 
ATOM   7277 C  C   . VAL B 1 470 ? -75.542 -12.468 -47.299 1.00 77.74  ?  470 VAL B C   1 
ATOM   7278 O  O   . VAL B 1 470 ? -76.443 -13.196 -47.767 1.00 80.12  ?  470 VAL B O   1 
ATOM   7279 C  CB  . VAL B 1 470 ? -75.430 -13.954 -45.247 1.00 70.39  ?  470 VAL B CB  1 
ATOM   7280 C  CG1 . VAL B 1 470 ? -74.543 -14.554 -44.169 1.00 70.08  ?  470 VAL B CG1 1 
ATOM   7281 C  CG2 . VAL B 1 470 ? -76.603 -13.213 -44.620 1.00 70.11  ?  470 VAL B CG2 1 
ATOM   7282 N  N   . ARG B 1 471 ? -75.329 -11.208 -47.697 1.00 82.25  ?  471 ARG B N   1 
ATOM   7283 C  CA  . ARG B 1 471 ? -76.168 -10.555 -48.745 1.00 84.84  ?  471 ARG B CA  1 
ATOM   7284 C  C   . ARG B 1 471 ? -75.739 -11.118 -50.109 1.00 81.13  ?  471 ARG B C   1 
ATOM   7285 O  O   . ARG B 1 471 ? -74.522 -11.260 -50.335 1.00 81.91  ?  471 ARG B O   1 
ATOM   7286 C  CB  . ARG B 1 471 ? -76.109 -9.025  -48.646 1.00 90.03  ?  471 ARG B CB  1 
ATOM   7287 C  CG  . ARG B 1 471 ? -74.861 -8.372  -49.224 1.00 97.82  ?  471 ARG B CG  1 
ATOM   7288 C  CD  . ARG B 1 471 ? -74.941 -6.853  -49.193 1.00 102.86 ?  471 ARG B CD  1 
ATOM   7289 N  NE  . ARG B 1 471 ? -75.718 -6.310  -50.305 1.00 107.04 ?  471 ARG B NE  1 
ATOM   7290 C  CZ  . ARG B 1 471 ? -75.276 -6.158  -51.555 1.00 109.03 ?  471 ARG B CZ  1 
ATOM   7291 N  NH1 . ARG B 1 471 ? -74.043 -6.511  -51.886 1.00 108.45 ?  471 ARG B NH1 1 
ATOM   7292 N  NH2 . ARG B 1 471 ? -76.077 -5.655  -52.479 1.00 109.98 ?  471 ARG B NH2 1 
ATOM   7293 N  N   . LEU B 1 472 ? -76.715 -11.465 -50.955 1.00 78.30  ?  472 LEU B N   1 
ATOM   7294 C  CA  . LEU B 1 472 ? -76.536 -12.102 -52.291 1.00 78.47  ?  472 LEU B CA  1 
ATOM   7295 C  C   . LEU B 1 472 ? -76.083 -13.561 -52.136 1.00 76.71  ?  472 LEU B C   1 
ATOM   7296 O  O   . LEU B 1 472 ? -75.660 -14.146 -53.156 1.00 79.38  ?  472 LEU B O   1 
ATOM   7297 C  CB  . LEU B 1 472 ? -75.524 -11.306 -53.125 1.00 79.61  ?  472 LEU B CB  1 
ATOM   7298 C  CG  . LEU B 1 472 ? -75.723 -9.789  -53.161 1.00 83.55  ?  472 LEU B CG  1 
ATOM   7299 C  CD1 . LEU B 1 472 ? -74.785 -9.150  -54.176 1.00 84.38  ?  472 LEU B CD1 1 
ATOM   7300 C  CD2 . LEU B 1 472 ? -77.168 -9.421  -53.470 1.00 83.08  ?  472 LEU B CD2 1 
ATOM   7301 N  N   . GLN B 1 473 ? -76.195 -14.132 -50.930 1.00 74.73  ?  473 GLN B N   1 
ATOM   7302 C  CA  . GLN B 1 473 ? -75.795 -15.535 -50.622 1.00 74.43  ?  473 GLN B CA  1 
ATOM   7303 C  C   . GLN B 1 473 ? -77.004 -16.347 -50.143 1.00 73.42  ?  473 GLN B C   1 
ATOM   7304 O  O   . GLN B 1 473 ? -77.871 -15.781 -49.450 1.00 73.46  ?  473 GLN B O   1 
ATOM   7305 C  CB  . GLN B 1 473 ? -74.710 -15.573 -49.548 1.00 74.73  ?  473 GLN B CB  1 
ATOM   7306 C  CG  . GLN B 1 473 ? -73.333 -15.187 -50.059 1.00 74.78  ?  473 GLN B CG  1 
ATOM   7307 C  CD  . GLN B 1 473 ? -72.292 -15.272 -48.971 1.00 74.45  ?  473 GLN B CD  1 
ATOM   7308 O  OE1 . GLN B 1 473 ? -72.476 -15.945 -47.958 1.00 72.12  ?  473 GLN B OE1 1 
ATOM   7309 N  NE2 . GLN B 1 473 ? -71.182 -14.582 -49.176 1.00 75.45  ?  473 GLN B NE2 1 
ATOM   7310 N  N   . ALA B 1 474 ? -77.028 -17.639 -50.481 1.00 73.65  ?  474 ALA B N   1 
ATOM   7311 C  CA  . ALA B 1 474 ? -78.078 -18.607 -50.078 1.00 73.97  ?  474 ALA B CA  1 
ATOM   7312 C  C   . ALA B 1 474 ? -77.526 -19.559 -49.011 1.00 69.81  ?  474 ALA B C   1 
ATOM   7313 O  O   . ALA B 1 474 ? -76.307 -19.527 -48.754 1.00 67.51  ?  474 ALA B O   1 
ATOM   7314 C  CB  . ALA B 1 474 ? -78.571 -19.369 -51.285 1.00 73.80  ?  474 ALA B CB  1 
ATOM   7315 N  N   . GLN B 1 475 ? -78.404 -20.364 -48.409 1.00 70.38  ?  475 GLN B N   1 
ATOM   7316 C  CA  . GLN B 1 475 ? -78.012 -21.540 -47.587 1.00 71.29  ?  475 GLN B CA  1 
ATOM   7317 C  C   . GLN B 1 475 ? -77.054 -22.387 -48.422 1.00 68.50  ?  475 GLN B C   1 
ATOM   7318 O  O   . GLN B 1 475 ? -77.389 -22.767 -49.541 1.00 66.51  ?  475 GLN B O   1 
ATOM   7319 C  CB  . GLN B 1 475 ? -79.248 -22.345 -47.178 1.00 74.13  ?  475 GLN B CB  1 
ATOM   7320 C  CG  . GLN B 1 475 ? -78.951 -23.483 -46.212 1.00 78.22  ?  475 GLN B CG  1 
ATOM   7321 C  CD  . GLN B 1 475 ? -78.501 -22.985 -44.861 1.00 82.16  ?  475 GLN B CD  1 
ATOM   7322 O  OE1 . GLN B 1 475 ? -78.840 -21.882 -44.440 1.00 87.53  ?  475 GLN B OE1 1 
ATOM   7323 N  NE2 . GLN B 1 475 ? -77.729 -23.803 -44.163 1.00 84.28  ?  475 GLN B NE2 1 
ATOM   7324 N  N   . PRO B 1 476 ? -75.834 -22.705 -47.933 1.00 67.67  ?  476 PRO B N   1 
ATOM   7325 C  CA  . PRO B 1 476 ? -74.909 -23.539 -48.698 1.00 66.12  ?  476 PRO B CA  1 
ATOM   7326 C  C   . PRO B 1 476 ? -75.447 -24.965 -48.891 1.00 65.46  ?  476 PRO B C   1 
ATOM   7327 O  O   . PRO B 1 476 ? -76.153 -25.465 -48.020 1.00 62.11  ?  476 PRO B O   1 
ATOM   7328 C  CB  . PRO B 1 476 ? -73.618 -23.565 -47.863 1.00 64.79  ?  476 PRO B CB  1 
ATOM   7329 C  CG  . PRO B 1 476 ? -73.775 -22.431 -46.872 1.00 65.31  ?  476 PRO B CG  1 
ATOM   7330 C  CD  . PRO B 1 476 ? -75.266 -22.289 -46.643 1.00 66.50  ?  476 PRO B CD  1 
ATOM   7331 N  N   . TRP B 1 477 ? -75.093 -25.574 -50.025 1.00 64.85  ?  477 TRP B N   1 
ATOM   7332 C  CA  . TRP B 1 477 ? -75.389 -26.996 -50.344 1.00 64.95  ?  477 TRP B CA  1 
ATOM   7333 C  C   . TRP B 1 477 ? -74.546 -27.890 -49.428 1.00 64.40  ?  477 TRP B C   1 
ATOM   7334 O  O   . TRP B 1 477 ? -73.302 -27.823 -49.524 1.00 66.44  ?  477 TRP B O   1 
ATOM   7335 C  CB  . TRP B 1 477 ? -75.127 -27.293 -51.825 1.00 63.90  ?  477 TRP B CB  1 
ATOM   7336 C  CG  . TRP B 1 477 ? -75.736 -26.299 -52.764 1.00 64.14  ?  477 TRP B CG  1 
ATOM   7337 C  CD1 . TRP B 1 477 ? -75.094 -25.280 -53.405 1.00 64.69  ?  477 TRP B CD1 1 
ATOM   7338 C  CD2 . TRP B 1 477 ? -77.116 -26.219 -53.167 1.00 64.38  ?  477 TRP B CD2 1 
ATOM   7339 N  NE1 . TRP B 1 477 ? -75.975 -24.576 -54.182 1.00 66.37  ?  477 TRP B NE1 1 
ATOM   7340 C  CE2 . TRP B 1 477 ? -77.223 -25.126 -54.055 1.00 65.89  ?  477 TRP B CE2 1 
ATOM   7341 C  CE3 . TRP B 1 477 ? -78.265 -26.959 -52.869 1.00 61.15  ?  477 TRP B CE3 1 
ATOM   7342 C  CZ2 . TRP B 1 477 ? -78.431 -24.761 -54.647 1.00 63.72  ?  477 TRP B CZ2 1 
ATOM   7343 C  CZ3 . TRP B 1 477 ? -79.459 -26.595 -53.451 1.00 62.64  ?  477 TRP B CZ3 1 
ATOM   7344 C  CH2 . TRP B 1 477 ? -79.539 -25.511 -54.327 1.00 63.48  ?  477 TRP B CH2 1 
ATOM   7345 N  N   . SER B 1 478 ? -75.201 -28.681 -48.571 1.00 63.82  ?  478 SER B N   1 
ATOM   7346 C  CA  . SER B 1 478 ? -74.546 -29.586 -47.586 1.00 63.32  ?  478 SER B CA  1 
ATOM   7347 C  C   . SER B 1 478 ? -73.766 -30.686 -48.315 1.00 65.88  ?  478 SER B C   1 
ATOM   7348 O  O   . SER B 1 478 ? -73.815 -30.726 -49.558 1.00 65.79  ?  478 SER B O   1 
ATOM   7349 C  CB  . SER B 1 478 ? -75.565 -30.170 -46.647 1.00 62.57  ?  478 SER B CB  1 
ATOM   7350 O  OG  . SER B 1 478 ? -76.542 -30.911 -47.361 1.00 63.31  ?  478 SER B OG  1 
ATOM   7351 N  N   . GLU B 1 479 ? -73.060 -31.537 -47.564 1.00 71.38  ?  479 GLU B N   1 
ATOM   7352 C  CA  . GLU B 1 479 ? -72.377 -32.748 -48.099 1.00 71.15  ?  479 GLU B CA  1 
ATOM   7353 C  C   . GLU B 1 479 ? -73.450 -33.705 -48.640 1.00 69.01  ?  479 GLU B C   1 
ATOM   7354 O  O   . GLU B 1 479 ? -73.236 -34.281 -49.726 1.00 67.95  ?  479 GLU B O   1 
ATOM   7355 C  CB  . GLU B 1 479 ? -71.497 -33.393 -47.023 1.00 67.73  ?  479 GLU B CB  1 
ATOM   7356 N  N   . ALA B 1 480 ? -74.570 -33.831 -47.917 1.00 65.95  ?  480 ALA B N   1 
ATOM   7357 C  CA  . ALA B 1 480 ? -75.746 -34.667 -48.268 1.00 65.79  ?  480 ALA B CA  1 
ATOM   7358 C  C   . ALA B 1 480 ? -76.314 -34.240 -49.628 1.00 64.18  ?  480 ALA B C   1 
ATOM   7359 O  O   . ALA B 1 480 ? -76.511 -35.121 -50.486 1.00 62.47  ?  480 ALA B O   1 
ATOM   7360 C  CB  . ALA B 1 480 ? -76.793 -34.562 -47.186 1.00 67.40  ?  480 ALA B CB  1 
ATOM   7361 N  N   . ASP B 1 481 ? -76.571 -32.940 -49.805 1.00 63.17  ?  481 ASP B N   1 
ATOM   7362 C  CA  . ASP B 1 481 ? -77.100 -32.346 -51.065 1.00 62.16  ?  481 ASP B CA  1 
ATOM   7363 C  C   . ASP B 1 481 ? -76.196 -32.735 -52.240 1.00 60.31  ?  481 ASP B C   1 
ATOM   7364 O  O   . ASP B 1 481 ? -76.733 -33.103 -53.302 1.00 57.24  ?  481 ASP B O   1 
ATOM   7365 C  CB  . ASP B 1 481 ? -77.192 -30.819 -50.988 1.00 63.76  ?  481 ASP B CB  1 
ATOM   7366 C  CG  . ASP B 1 481 ? -78.078 -30.281 -49.877 1.00 66.30  ?  481 ASP B CG  1 
ATOM   7367 O  OD1 . ASP B 1 481 ? -79.064 -30.957 -49.514 1.00 66.45  ?  481 ASP B OD1 1 
ATOM   7368 O  OD2 . ASP B 1 481 ? -77.770 -29.182 -49.380 1.00 70.06  -1 481 ASP B OD2 1 
ATOM   7369 N  N   . ARG B 1 482 ? -74.876 -32.648 -52.047 1.00 63.51  ?  482 ARG B N   1 
ATOM   7370 C  CA  . ARG B 1 482 ? -73.859 -32.896 -53.111 1.00 67.02  ?  482 ARG B CA  1 
ATOM   7371 C  C   . ARG B 1 482 ? -73.790 -34.398 -53.398 1.00 63.59  ?  482 ARG B C   1 
ATOM   7372 O  O   . ARG B 1 482 ? -73.600 -34.766 -54.569 1.00 62.39  ?  482 ARG B O   1 
ATOM   7373 C  CB  . ARG B 1 482 ? -72.486 -32.361 -52.693 1.00 72.45  ?  482 ARG B CB  1 
ATOM   7374 C  CG  . ARG B 1 482 ? -72.388 -30.842 -52.680 1.00 78.01  ?  482 ARG B CG  1 
ATOM   7375 C  CD  . ARG B 1 482 ? -71.160 -30.350 -51.934 1.00 85.02  ?  482 ARG B CD  1 
ATOM   7376 N  NE  . ARG B 1 482 ? -70.885 -28.936 -52.165 1.00 89.41  ?  482 ARG B NE  1 
ATOM   7377 C  CZ  . ARG B 1 482 ? -70.373 -28.427 -53.287 1.00 92.50  ?  482 ARG B CZ  1 
ATOM   7378 N  NH1 . ARG B 1 482 ? -70.077 -29.208 -54.316 1.00 91.92  ?  482 ARG B NH1 1 
ATOM   7379 N  NH2 . ARG B 1 482 ? -70.165 -27.124 -53.377 1.00 92.46  ?  482 ARG B NH2 1 
ATOM   7380 N  N   . GLU B 1 483 ? -73.942 -35.226 -52.363 1.00 64.38  ?  483 GLU B N   1 
ATOM   7381 C  CA  . GLU B 1 483 ? -73.882 -36.707 -52.471 1.00 65.42  ?  483 GLU B CA  1 
ATOM   7382 C  C   . GLU B 1 483 ? -75.101 -37.191 -53.266 1.00 63.50  ?  483 GLU B C   1 
ATOM   7383 O  O   . GLU B 1 483 ? -74.919 -38.041 -54.158 1.00 65.24  ?  483 GLU B O   1 
ATOM   7384 C  CB  . GLU B 1 483 ? -73.802 -37.349 -51.085 1.00 71.68  ?  483 GLU B CB  1 
ATOM   7385 C  CG  . GLU B 1 483 ? -72.991 -38.634 -51.067 1.00 78.98  ?  483 GLU B CG  1 
ATOM   7386 C  CD  . GLU B 1 483 ? -72.929 -39.353 -49.729 1.00 83.01  ?  483 GLU B CD  1 
ATOM   7387 O  OE1 . GLU B 1 483 ? -73.169 -38.698 -48.690 1.00 82.72  ?  483 GLU B OE1 1 
ATOM   7388 O  OE2 . GLU B 1 483 ? -72.638 -40.569 -49.730 1.00 86.50  -1 483 GLU B OE2 1 
ATOM   7389 N  N   . ILE B 1 484 ? -76.285 -36.645 -52.964 1.00 59.28  ?  484 ILE B N   1 
ATOM   7390 C  CA  . ILE B 1 484 ? -77.574 -36.943 -53.663 1.00 57.18  ?  484 ILE B CA  1 
ATOM   7391 C  C   . ILE B 1 484 ? -77.487 -36.466 -55.118 1.00 57.80  ?  484 ILE B C   1 
ATOM   7392 O  O   . ILE B 1 484 ? -77.908 -37.225 -56.015 1.00 59.25  ?  484 ILE B O   1 
ATOM   7393 C  CB  . ILE B 1 484 ? -78.761 -36.300 -52.920 1.00 56.81  ?  484 ILE B CB  1 
ATOM   7394 C  CG1 . ILE B 1 484 ? -78.987 -36.964 -51.558 1.00 57.46  ?  484 ILE B CG1 1 
ATOM   7395 C  CG2 . ILE B 1 484 ? -80.020 -36.326 -53.777 1.00 56.55  ?  484 ILE B CG2 1 
ATOM   7396 C  CD1 . ILE B 1 484 ? -79.847 -36.166 -50.608 1.00 56.81  ?  484 ILE B CD1 1 
ATOM   7397 N  N   . ALA B 1 485 ? -76.982 -35.248 -55.334 1.00 57.37  ?  485 ALA B N   1 
ATOM   7398 C  CA  . ALA B 1 485 ? -76.798 -34.628 -56.669 1.00 57.10  ?  485 ALA B CA  1 
ATOM   7399 C  C   . ALA B 1 485 ? -75.936 -35.535 -57.557 1.00 57.43  ?  485 ALA B C   1 
ATOM   7400 O  O   . ALA B 1 485 ? -76.291 -35.714 -58.741 1.00 58.86  ?  485 ALA B O   1 
ATOM   7401 C  CB  . ALA B 1 485 ? -76.177 -33.261 -56.526 1.00 57.28  ?  485 ALA B CB  1 
ATOM   7402 N  N   . GLU B 1 486 ? -74.846 -36.079 -57.006 1.00 56.97  ?  486 GLU B N   1 
ATOM   7403 C  CA  . GLU B 1 486 ? -73.883 -36.944 -57.744 1.00 58.40  ?  486 GLU B CA  1 
ATOM   7404 C  C   . GLU B 1 486 ? -74.558 -38.283 -58.072 1.00 56.10  ?  486 GLU B C   1 
ATOM   7405 O  O   . GLU B 1 486 ? -74.303 -38.807 -59.175 1.00 57.42  ?  486 GLU B O   1 
ATOM   7406 C  CB  . GLU B 1 486 ? -72.586 -37.116 -56.944 1.00 60.52  ?  486 GLU B CB  1 
ATOM   7407 C  CG  . GLU B 1 486 ? -71.580 -38.078 -57.563 1.00 61.34  ?  486 GLU B CG  1 
ATOM   7408 C  CD  . GLU B 1 486 ? -71.015 -37.705 -58.926 1.00 63.08  ?  486 GLU B CD  1 
ATOM   7409 O  OE1 . GLU B 1 486 ? -71.345 -36.612 -59.441 1.00 62.67  ?  486 GLU B OE1 1 
ATOM   7410 O  OE2 . GLU B 1 486 ? -70.237 -38.518 -59.478 1.00 61.52  -1 486 GLU B OE2 1 
ATOM   7411 N  N   . THR B 1 487 ? -75.395 -38.809 -57.170 1.00 53.15  ?  487 THR B N   1 
ATOM   7412 C  CA  . THR B 1 487 ? -76.169 -40.061 -57.409 1.00 53.65  ?  487 THR B CA  1 
ATOM   7413 C  C   . THR B 1 487 ? -77.188 -39.818 -58.532 1.00 53.33  ?  487 THR B C   1 
ATOM   7414 O  O   . THR B 1 487 ? -77.292 -40.676 -59.431 1.00 52.08  ?  487 THR B O   1 
ATOM   7415 C  CB  . THR B 1 487 ? -76.844 -40.573 -56.132 1.00 53.31  ?  487 THR B CB  1 
ATOM   7416 O  OG1 . THR B 1 487 ? -75.834 -40.786 -55.147 1.00 52.85  ?  487 THR B OG1 1 
ATOM   7417 C  CG2 . THR B 1 487 ? -77.613 -41.858 -56.352 1.00 53.46  ?  487 THR B CG2 1 
ATOM   7418 N  N   . ALA B 1 488 ? -77.909 -38.694 -58.477 1.00 52.01  ?  488 ALA B N   1 
ATOM   7419 C  CA  . ALA B 1 488 ? -78.907 -38.282 -59.493 1.00 53.31  ?  488 ALA B CA  1 
ATOM   7420 C  C   . ALA B 1 488 ? -78.231 -38.151 -60.865 1.00 53.89  ?  488 ALA B C   1 
ATOM   7421 O  O   . ALA B 1 488 ? -78.798 -38.658 -61.854 1.00 54.24  ?  488 ALA B O   1 
ATOM   7422 C  CB  . ALA B 1 488 ? -79.572 -36.993 -59.072 1.00 53.57  ?  488 ALA B CB  1 
ATOM   7423 N  N   . ARG B 1 489 ? -77.061 -37.504 -60.918 1.00 54.09  ?  489 ARG B N   1 
ATOM   7424 C  CA  . ARG B 1 489 ? -76.275 -37.335 -62.177 1.00 56.60  ?  489 ARG B CA  1 
ATOM   7425 C  C   . ARG B 1 489 ? -76.045 -38.709 -62.813 1.00 57.03  ?  489 ARG B C   1 
ATOM   7426 O  O   . ARG B 1 489 ? -76.319 -38.857 -64.019 1.00 57.05  ?  489 ARG B O   1 
ATOM   7427 C  CB  . ARG B 1 489 ? -74.920 -36.669 -61.921 1.00 58.70  ?  489 ARG B CB  1 
ATOM   7428 C  CG  . ARG B 1 489 ? -74.081 -36.460 -63.177 1.00 59.86  ?  489 ARG B CG  1 
ATOM   7429 C  CD  . ARG B 1 489 ? -72.694 -35.921 -62.869 1.00 62.01  ?  489 ARG B CD  1 
ATOM   7430 N  NE  . ARG B 1 489 ? -71.826 -36.909 -62.235 1.00 61.89  ?  489 ARG B NE  1 
ATOM   7431 C  CZ  . ARG B 1 489 ? -71.120 -37.838 -62.879 1.00 61.35  ?  489 ARG B CZ  1 
ATOM   7432 N  NH1 . ARG B 1 489 ? -71.173 -37.929 -64.197 1.00 62.10  ?  489 ARG B NH1 1 
ATOM   7433 N  NH2 . ARG B 1 489 ? -70.362 -38.682 -62.201 1.00 62.53  ?  489 ARG B NH2 1 
ATOM   7434 N  N   . ILE B 1 490 ? -75.553 -39.665 -62.022 1.00 55.21  ?  490 ILE B N   1 
ATOM   7435 C  CA  . ILE B 1 490 ? -75.194 -41.035 -62.493 1.00 54.50  ?  490 ILE B CA  1 
ATOM   7436 C  C   . ILE B 1 490 ? -76.463 -41.748 -62.974 1.00 53.04  ?  490 ILE B C   1 
ATOM   7437 O  O   . ILE B 1 490 ? -76.389 -42.441 -64.000 1.00 53.98  ?  490 ILE B O   1 
ATOM   7438 C  CB  . ILE B 1 490 ? -74.446 -41.812 -61.392 1.00 54.82  ?  490 ILE B CB  1 
ATOM   7439 C  CG1 . ILE B 1 490 ? -73.063 -41.204 -61.143 1.00 55.04  ?  490 ILE B CG1 1 
ATOM   7440 C  CG2 . ILE B 1 490 ? -74.361 -43.295 -61.730 1.00 54.35  ?  490 ILE B CG2 1 
ATOM   7441 C  CD1 . ILE B 1 490 ? -72.441 -41.598 -59.825 1.00 56.72  ?  490 ILE B CD1 1 
ATOM   7442 N  N   . ALA B 1 491 ? -77.581 -41.581 -62.267 1.00 54.01  ?  491 ALA B N   1 
ATOM   7443 C  CA  . ALA B 1 491 ? -78.892 -42.165 -62.636 1.00 55.79  ?  491 ALA B CA  1 
ATOM   7444 C  C   . ALA B 1 491 ? -79.341 -41.599 -63.985 1.00 56.29  ?  491 ALA B C   1 
ATOM   7445 O  O   . ALA B 1 491 ? -79.645 -42.394 -64.884 1.00 57.72  ?  491 ALA B O   1 
ATOM   7446 C  CB  . ALA B 1 491 ? -79.916 -41.889 -61.567 1.00 58.04  ?  491 ALA B CB  1 
ATOM   7447 N  N   . LEU B 1 492 ? -79.369 -40.272 -64.115 1.00 59.11  ?  492 LEU B N   1 
ATOM   7448 C  CA  . LEU B 1 492 ? -79.920 -39.576 -65.309 1.00 61.66  ?  492 LEU B CA  1 
ATOM   7449 C  C   . LEU B 1 492 ? -78.992 -39.777 -66.513 1.00 62.34  ?  492 LEU B C   1 
ATOM   7450 O  O   . LEU B 1 492 ? -79.496 -40.179 -67.576 1.00 64.44  ?  492 LEU B O   1 
ATOM   7451 C  CB  . LEU B 1 492 ? -80.126 -38.094 -64.981 1.00 63.90  ?  492 LEU B CB  1 
ATOM   7452 C  CG  . LEU B 1 492 ? -81.259 -37.810 -63.995 1.00 65.89  ?  492 LEU B CG  1 
ATOM   7453 C  CD1 . LEU B 1 492 ? -81.273 -36.347 -63.586 1.00 67.65  ?  492 LEU B CD1 1 
ATOM   7454 C  CD2 . LEU B 1 492 ? -82.606 -38.210 -64.578 1.00 65.58  ?  492 LEU B CD2 1 
ATOM   7455 N  N   . VAL B 1 493 ? -77.692 -39.517 -66.351 1.00 63.62  ?  493 VAL B N   1 
ATOM   7456 C  CA  . VAL B 1 493 ? -76.670 -39.697 -67.427 1.00 62.55  ?  493 VAL B CA  1 
ATOM   7457 C  C   . VAL B 1 493 ? -76.727 -41.153 -67.897 1.00 62.55  ?  493 VAL B C   1 
ATOM   7458 O  O   . VAL B 1 493 ? -76.644 -41.380 -69.117 1.00 65.82  ?  493 VAL B O   1 
ATOM   7459 C  CB  . VAL B 1 493 ? -75.256 -39.306 -66.956 1.00 63.18  ?  493 VAL B CB  1 
ATOM   7460 C  CG1 . VAL B 1 493 ? -74.175 -39.832 -67.888 1.00 65.30  ?  493 VAL B CG1 1 
ATOM   7461 C  CG2 . VAL B 1 493 ? -75.117 -37.800 -66.791 1.00 62.53  ?  493 VAL B CG2 1 
ATOM   7462 N  N   . GLY B 1 494 ? -76.869 -42.088 -66.955 1.00 63.15  ?  494 GLY B N   1 
ATOM   7463 C  CA  . GLY B 1 494 ? -76.966 -43.536 -67.221 1.00 65.26  ?  494 GLY B CA  1 
ATOM   7464 C  C   . GLY B 1 494 ? -78.138 -43.869 -68.126 1.00 66.69  ?  494 GLY B C   1 
ATOM   7465 O  O   . GLY B 1 494 ? -77.936 -44.619 -69.101 1.00 66.53  ?  494 GLY B O   1 
ATOM   7466 N  N   . VAL B 1 495 ? -79.320 -43.331 -67.814 1.00 69.97  ?  495 VAL B N   1 
ATOM   7467 C  CA  . VAL B 1 495 ? -80.599 -43.639 -68.524 1.00 71.62  ?  495 VAL B CA  1 
ATOM   7468 C  C   . VAL B 1 495 ? -80.649 -42.850 -69.841 1.00 70.22  ?  495 VAL B C   1 
ATOM   7469 O  O   . VAL B 1 495 ? -81.263 -43.354 -70.794 1.00 71.58  ?  495 VAL B O   1 
ATOM   7470 C  CB  . VAL B 1 495 ? -81.828 -43.373 -67.629 1.00 72.22  ?  495 VAL B CB  1 
ATOM   7471 C  CG1 . VAL B 1 495 ? -82.139 -41.893 -67.465 1.00 72.12  ?  495 VAL B CG1 1 
ATOM   7472 C  CG2 . VAL B 1 495 ? -83.053 -44.115 -68.131 1.00 74.50  ?  495 VAL B CG2 1 
ATOM   7473 N  N   . ALA B 1 496 ? -80.024 -41.670 -69.892 1.00 72.47  ?  496 ALA B N   1 
ATOM   7474 C  CA  . ALA B 1 496 ? -79.910 -40.822 -71.108 1.00 75.62  ?  496 ALA B CA  1 
ATOM   7475 C  C   . ALA B 1 496 ? -79.097 -41.553 -72.183 1.00 74.93  ?  496 ALA B C   1 
ATOM   7476 O  O   . ALA B 1 496 ? -79.431 -41.412 -73.371 1.00 76.79  ?  496 ALA B O   1 
ATOM   7477 C  CB  . ALA B 1 496 ? -79.290 -39.487 -70.771 1.00 75.91  ?  496 ALA B CB  1 
ATOM   7478 N  N   . PHE B 1 497 ? -78.071 -42.300 -71.768 1.00 78.75  ?  497 PHE B N   1 
ATOM   7479 C  CA  . PHE B 1 497 ? -77.169 -43.087 -72.653 1.00 80.96  ?  497 PHE B CA  1 
ATOM   7480 C  C   . PHE B 1 497 ? -77.949 -44.262 -73.254 1.00 87.96  ?  497 PHE B C   1 
ATOM   7481 O  O   . PHE B 1 497 ? -77.767 -44.551 -74.453 1.00 91.60  ?  497 PHE B O   1 
ATOM   7482 C  CB  . PHE B 1 497 ? -75.939 -43.560 -71.874 1.00 75.66  ?  497 PHE B CB  1 
ATOM   7483 C  CG  . PHE B 1 497 ? -74.770 -43.987 -72.724 1.00 73.13  ?  497 PHE B CG  1 
ATOM   7484 C  CD1 . PHE B 1 497 ? -74.077 -43.063 -73.491 1.00 73.82  ?  497 PHE B CD1 1 
ATOM   7485 C  CD2 . PHE B 1 497 ? -74.346 -45.306 -72.739 1.00 73.00  ?  497 PHE B CD2 1 
ATOM   7486 C  CE1 . PHE B 1 497 ? -72.997 -43.454 -74.266 1.00 73.63  ?  497 PHE B CE1 1 
ATOM   7487 C  CE2 . PHE B 1 497 ? -73.263 -45.695 -73.513 1.00 72.22  ?  497 PHE B CE2 1 
ATOM   7488 C  CZ  . PHE B 1 497 ? -72.590 -44.768 -74.274 1.00 73.15  ?  497 PHE B CZ  1 
ATOM   7489 N  N   . HIS B 1 498 ? -78.799 -44.901 -72.443 1.00 95.25  ?  498 HIS B N   1 
ATOM   7490 C  CA  . HIS B 1 498 ? -79.642 -46.072 -72.815 1.00 102.54 ?  498 HIS B CA  1 
ATOM   7491 C  C   . HIS B 1 498 ? -80.618 -45.691 -73.937 1.00 107.40 ?  498 HIS B C   1 
ATOM   7492 O  O   . HIS B 1 498 ? -80.889 -46.557 -74.789 1.00 114.19 ?  498 HIS B O   1 
ATOM   7493 C  CB  . HIS B 1 498 ? -80.368 -46.615 -71.575 1.00 107.26 ?  498 HIS B CB  1 
ATOM   7494 C  CG  . HIS B 1 498 ? -81.230 -47.806 -71.836 1.00 115.12 ?  498 HIS B CG  1 
ATOM   7495 N  ND1 . HIS B 1 498 ? -80.877 -49.078 -71.424 1.00 121.73 ?  498 HIS B ND1 1 
ATOM   7496 C  CD2 . HIS B 1 498 ? -82.428 -47.925 -72.449 1.00 118.53 ?  498 HIS B CD2 1 
ATOM   7497 C  CE1 . HIS B 1 498 ? -81.818 -49.930 -71.779 1.00 122.13 ?  498 HIS B CE1 1 
ATOM   7498 N  NE2 . HIS B 1 498 ? -82.780 -49.248 -72.411 1.00 122.23 ?  498 HIS B NE2 1 
ATOM   7499 N  N   . HIS B 1 499 ? -81.119 -44.450 -73.934 1.00 113.71 ?  499 HIS B N   1 
ATOM   7500 C  CA  . HIS B 1 499 ? -82.144 -43.928 -74.883 1.00 116.08 ?  499 HIS B CA  1 
ATOM   7501 C  C   . HIS B 1 499 ? -81.487 -43.261 -76.099 1.00 118.65 ?  499 HIS B C   1 
ATOM   7502 O  O   . HIS B 1 499 ? -82.230 -42.874 -77.021 1.00 119.56 ?  499 HIS B O   1 
ATOM   7503 C  CB  . HIS B 1 499 ? -83.090 -42.950 -74.169 1.00 114.53 ?  499 HIS B CB  1 
ATOM   7504 C  CG  . HIS B 1 499 ? -84.081 -43.611 -73.272 1.00 113.75 ?  499 HIS B CG  1 
ATOM   7505 N  ND1 . HIS B 1 499 ? -85.434 -43.351 -73.353 1.00 114.70 ?  499 HIS B ND1 1 
ATOM   7506 C  CD2 . HIS B 1 499 ? -83.927 -44.519 -72.283 1.00 113.97 ?  499 HIS B CD2 1 
ATOM   7507 C  CE1 . HIS B 1 499 ? -86.071 -44.067 -72.449 1.00 114.60 ?  499 HIS B CE1 1 
ATOM   7508 N  NE2 . HIS B 1 499 ? -85.169 -44.792 -71.779 1.00 112.79 ?  499 HIS B NE2 1 
ATOM   7509 N  N   . SER B 1 500 ? -80.157 -43.119 -76.094 1.00 122.78 ?  500 SER B N   1 
ATOM   7510 C  CA  . SER B 1 500 ? -79.367 -42.468 -77.178 1.00 125.80 ?  500 SER B CA  1 
ATOM   7511 C  C   . SER B 1 500 ? -79.006 -43.492 -78.261 1.00 126.64 ?  500 SER B C   1 
ATOM   7512 O  O   . SER B 1 500 ? -79.823 -44.306 -78.694 1.00 123.53 ?  500 SER B O   1 
ATOM   7513 C  CB  . SER B 1 500 ? -78.134 -41.803 -76.623 1.00 126.59 ?  500 SER B CB  1 
ATOM   7514 O  OG  . SER B 1 500 ? -77.520 -40.975 -77.600 1.00 126.56 ?  500 SER B OG  1 
HETATM 7515 C  C1A A EL5 C 2 .   ? -42.290 24.863  -15.589 0.50 86.09  ?  601 EL5 A C1A 1 
HETATM 7516 C  C1A B EL5 C 2 .   ? -42.435 24.925  -15.697 0.50 79.86  ?  601 EL5 A C1A 1 
HETATM 7517 C  C1B A EL5 C 2 .   ? -43.013 21.128  -17.874 0.50 88.81  ?  601 EL5 A C1B 1 
HETATM 7518 C  C1B B EL5 C 2 .   ? -42.959 21.116  -17.947 0.50 82.41  ?  601 EL5 A C1B 1 
HETATM 7519 O  O1B A EL5 C 2 .   ? -43.142 17.804  -23.237 0.50 104.97 ?  601 EL5 A O1B 1 
HETATM 7520 O  O1B B EL5 C 2 .   ? -40.977 17.177  -23.347 0.50 98.52  ?  601 EL5 A O1B 1 
HETATM 7521 C  C1C A EL5 C 2 .   ? -38.793 20.587  -18.745 0.50 84.40  ?  601 EL5 A C1C 1 
HETATM 7522 C  C1C B EL5 C 2 .   ? -38.720 20.685  -18.718 0.50 78.58  ?  601 EL5 A C1C 1 
HETATM 7523 O  O1C A EL5 C 2 .   ? -36.857 16.926  -21.651 0.50 98.78  ?  601 EL5 A O1C 1 
HETATM 7524 O  O1C B EL5 C 2 .   ? -35.759 18.583  -23.043 0.50 81.41  ?  601 EL5 A O1C 1 
HETATM 7525 C  C1D A EL5 C 2 .   ? -35.861 23.934  -17.314 0.50 79.24  ?  601 EL5 A C1D 1 
HETATM 7526 C  C1D B EL5 C 2 .   ? -36.298 24.372  -16.875 0.50 80.08  ?  601 EL5 A C1D 1 
HETATM 7527 C  C2A A EL5 C 2 .   ? -43.534 24.761  -14.996 0.50 86.64  ?  601 EL5 A C2A 1 
HETATM 7528 C  C2A B EL5 C 2 .   ? -43.673 24.752  -15.108 0.50 80.57  ?  601 EL5 A C2A 1 
HETATM 7529 C  C2B A EL5 C 2 .   ? -43.481 20.121  -18.709 0.50 90.05  ?  601 EL5 A C2B 1 
HETATM 7530 C  C2B B EL5 C 2 .   ? -43.382 20.046  -18.725 0.50 83.39  ?  601 EL5 A C2B 1 
HETATM 7531 O  O2B A EL5 C 2 .   ? -40.968 17.430  -23.387 0.50 108.78 ?  601 EL5 A O2B 1 
HETATM 7532 O  O2B B EL5 C 2 .   ? -43.109 17.679  -23.047 0.50 93.97  ?  601 EL5 A O2B 1 
HETATM 7533 C  C2C A EL5 C 2 .   ? -37.486 20.310  -19.126 0.50 85.15  ?  601 EL5 A C2C 1 
HETATM 7534 C  C2C B EL5 C 2 .   ? -37.380 20.467  -19.016 0.50 78.29  ?  601 EL5 A C2C 1 
HETATM 7535 O  O2C A EL5 C 2 .   ? -36.975 15.530  -19.952 0.50 101.57 ?  601 EL5 A O2C 1 
HETATM 7536 O  O2C B EL5 C 2 .   ? -37.461 17.435  -22.250 0.50 80.85  ?  601 EL5 A O2C 1 
HETATM 7537 C  C2D A EL5 C 2 .   ? -35.399 25.026  -16.592 0.50 78.94  ?  601 EL5 A C2D 1 
HETATM 7538 C  C2D B EL5 C 2 .   ? -35.119 24.443  -17.608 0.50 79.90  ?  601 EL5 A C2D 1 
HETATM 7539 C  C3A A EL5 C 2 .   ? -44.284 23.693  -15.443 0.50 87.90  ?  601 EL5 A C3A 1 
HETATM 7540 C  C3A B EL5 C 2 .   ? -44.357 23.639  -15.547 0.50 82.26  ?  601 EL5 A C3A 1 
HETATM 7541 C  C3B A EL5 C 2 .   ? -42.374 19.567  -19.339 0.50 90.72  ?  601 EL5 A C3B 1 
HETATM 7542 C  C3B B EL5 C 2 .   ? -42.249 19.503  -19.318 0.50 83.90  ?  601 EL5 A C3B 1 
HETATM 7543 C  C3C A EL5 C 2 .   ? -36.663 21.212  -18.481 0.50 82.82  ?  601 EL5 A C3C 1 
HETATM 7544 C  C3C B EL5 C 2 .   ? -36.640 21.436  -18.361 0.50 78.00  ?  601 EL5 A C3C 1 
HETATM 7545 C  C3D A EL5 C 2 .   ? -34.228 25.474  -17.187 0.50 78.58  ?  601 EL5 A C3D 1 
HETATM 7546 C  C3D B EL5 C 2 .   ? -34.416 25.560  -17.172 0.50 80.00  ?  601 EL5 A C3D 1 
HETATM 7547 C  C4A A EL5 C 2 .   ? -43.430 23.064  -16.343 0.50 87.53  ?  601 EL5 A C4A 1 
HETATM 7548 C  C4A B EL5 C 2 .   ? -43.468 23.062  -16.448 0.50 81.66  ?  601 EL5 A C4A 1 
HETATM 7549 C  C4B A EL5 C 2 .   ? -41.265 20.217  -18.816 0.50 88.72  ?  601 EL5 A C4B 1 
HETATM 7550 C  C4B B EL5 C 2 .   ? -41.167 20.214  -18.820 0.50 82.32  ?  601 EL5 A C4B 1 
HETATM 7551 C  C4C A EL5 C 2 .   ? -37.447 22.076  -17.726 0.50 80.95  ?  601 EL5 A C4C 1 
HETATM 7552 C  C4C B EL5 C 2 .   ? -37.514 22.281  -17.683 0.50 77.61  ?  601 EL5 A C4C 1 
HETATM 7553 C  C4D A EL5 C 2 .   ? -33.978 24.654  -18.282 0.50 78.27  ?  601 EL5 A C4D 1 
HETATM 7554 C  C4D B EL5 C 2 .   ? -35.168 26.181  -16.186 0.50 80.26  ?  601 EL5 A C4D 1 
HETATM 7555 C  CAA A EL5 C 2 .   ? -45.556 23.300  -14.972 0.50 91.95  ?  601 EL5 A CAA 1 
HETATM 7556 C  CAA B EL5 C 2 .   ? -45.600 23.184  -15.078 0.50 86.96  ?  601 EL5 A CAA 1 
HETATM 7557 C  CAB A EL5 C 2 .   ? -42.336 18.488  -20.380 0.50 94.76  ?  601 EL5 A CAB 1 
HETATM 7558 C  CAB B EL5 C 2 .   ? -42.171 18.370  -20.296 0.50 87.14  ?  601 EL5 A CAB 1 
HETATM 7559 C  CAC A EL5 C 2 .   ? -37.062 19.197  -20.043 0.50 88.65  ?  601 EL5 A CAC 1 
HETATM 7560 C  CAC B EL5 C 2 .   ? -36.851 19.358  -19.880 0.50 78.85  ?  601 EL5 A CAC 1 
HETATM 7561 C  CAD A EL5 C 2 .   ? -33.431 26.545  -16.760 0.50 78.08  ?  601 EL5 A CAD 1 
HETATM 7562 C  CAD B EL5 C 2 .   ? -33.173 26.023  -17.610 0.50 80.09  ?  601 EL5 A CAD 1 
HETATM 7563 C  CBA A EL5 C 2 .   ? -46.270 24.044  -14.127 0.50 95.60  ?  601 EL5 A CBA 1 
HETATM 7564 C  CBA B EL5 C 2 .   ? -46.291 23.818  -14.133 0.50 91.74  ?  601 EL5 A CBA 1 
HETATM 7565 C  CBB A EL5 C 2 .   ? -41.717 18.941  -21.706 0.50 100.70 ?  601 EL5 A CBB 1 
HETATM 7566 C  CBB B EL5 C 2 .   ? -41.515 18.732  -21.627 0.50 91.69  ?  601 EL5 A CBB 1 
HETATM 7567 C  CBC A EL5 C 2 .   ? -37.492 17.820  -19.539 0.50 91.87  ?  601 EL5 A CBC 1 
HETATM 7568 C  CBC B EL5 C 2 .   ? -37.087 19.610  -21.361 0.50 79.88  ?  601 EL5 A CBC 1 
HETATM 7569 C  CBD A EL5 C 2 .   ? -32.278 26.910  -17.295 0.50 76.24  ?  601 EL5 A CBD 1 
HETATM 7570 C  CBD B EL5 C 2 .   ? -32.552 27.088  -17.130 0.50 78.24  ?  601 EL5 A CBD 1 
HETATM 7571 C  CGB A EL5 C 2 .   ? -41.960 17.986  -22.863 0.50 105.25 ?  601 EL5 A CGB 1 
HETATM 7572 C  CGB B EL5 C 2 .   ? -41.894 17.795  -22.761 0.50 95.24  ?  601 EL5 A CGB 1 
HETATM 7573 C  CGC A EL5 C 2 .   ? -37.074 16.674  -20.447 0.50 96.69  ?  601 EL5 A CGC 1 
HETATM 7574 C  CGC B EL5 C 2 .   ? -36.734 18.449  -22.276 0.50 79.92  ?  601 EL5 A CGC 1 
HETATM 7575 C  CHB A EL5 C 2 .   ? -43.778 21.893  -17.001 0.50 88.16  ?  601 EL5 A CHB 1 
HETATM 7576 C  CHB B EL5 C 2 .   ? -43.760 21.875  -17.103 0.50 82.11  ?  601 EL5 A CHB 1 
HETATM 7577 C  CHC A EL5 C 2 .   ? -39.950 19.955  -19.179 0.50 86.43  ?  601 EL5 A CHC 1 
HETATM 7578 C  CHC B EL5 C 2 .   ? -39.837 19.988  -19.157 0.50 80.28  ?  601 EL5 A CHC 1 
HETATM 7579 C  CHD A EL5 C 2 .   ? -36.965 23.158  -16.998 0.50 79.50  ?  601 EL5 A CHD 1 
HETATM 7580 C  CHD B EL5 C 2 .   ? -37.296 23.408  -16.896 0.50 78.45  ?  601 EL5 A CHD 1 
HETATM 7581 C  CMA A EL5 C 2 .   ? -44.026 25.727  -13.960 0.50 87.86  ?  601 EL5 A CMA 1 
HETATM 7582 C  CMA B EL5 C 2 .   ? -44.221 25.690  -14.074 0.50 81.66  ?  601 EL5 A CMA 1 
HETATM 7583 C  CMB A EL5 C 2 .   ? -44.916 19.750  -18.942 0.50 91.33  ?  601 EL5 A CMB 1 
HETATM 7584 C  CMB B EL5 C 2 .   ? -44.800 19.611  -18.947 0.50 84.58  ?  601 EL5 A CMB 1 
HETATM 7585 C  CMC A EL5 C 2 .   ? -35.172 21.276  -18.582 0.50 83.51  ?  601 EL5 A CMC 1 
HETATM 7586 C  CMC B EL5 C 2 .   ? -35.152 21.580  -18.393 0.50 79.28  ?  601 EL5 A CMC 1 
HETATM 7587 C  CMD A EL5 C 2 .   ? -36.033 25.603  -15.360 0.50 78.53  ?  601 EL5 A CMD 1 
HETATM 7588 C  CMD B EL5 C 2 .   ? -34.660 23.494  -18.677 0.50 79.79  ?  601 EL5 A CMD 1 
HETATM 7589 N  NA  A EL5 C 2 .   ? -42.225 23.772  -16.446 0.50 87.41  ?  601 EL5 A NA  1 
HETATM 7590 N  NA  B EL5 C 2 .   ? -42.303 23.836  -16.550 0.50 81.41  ?  601 EL5 A NA  1 
HETATM 7591 O  OA  A EL5 C 2 .   ? -41.432 25.691  -15.408 0.50 84.29  ?  601 EL5 A OA  1 
HETATM 7592 O  OA  B EL5 C 2 .   ? -41.625 25.800  -15.511 0.50 77.29  ?  601 EL5 A OA  1 
HETATM 7593 N  NB  A EL5 C 2 .   ? -41.645 21.144  -17.888 0.50 87.81  ?  601 EL5 A NB  1 
HETATM 7594 N  NB  B EL5 C 2 .   ? -41.591 21.170  -17.939 0.50 81.36  ?  601 EL5 A NB  1 
HETATM 7595 N  NC  A EL5 C 2 .   ? -38.752 21.675  -17.901 0.50 83.25  ?  601 EL5 A NC  1 
HETATM 7596 N  NC  B EL5 C 2 .   ? -38.778 21.784  -17.894 0.50 78.77  ?  601 EL5 A NC  1 
HETATM 7597 N  ND  A EL5 C 2 .   ? -34.981 23.716  -18.351 0.50 78.89  ?  601 EL5 A ND  1 
HETATM 7598 N  ND  B EL5 C 2 .   ? -36.319 25.452  -16.017 0.50 80.68  ?  601 EL5 A ND  1 
HETATM 7599 O  OD  A EL5 C 2 .   ? -33.036 24.722  -19.054 0.50 77.69  ?  601 EL5 A OD  1 
HETATM 7600 O  OD  B EL5 C 2 .   ? -34.886 27.199  -15.570 0.50 80.12  ?  601 EL5 A OD  1 
HETATM 7601 S  S   . SO4 D 3 .   ? -0.000  -0.000  18.635  0.33 134.11 ?  602 SO4 A S   1 
HETATM 7602 O  O1  . SO4 D 3 .   ? -1.322  -0.301  19.114  0.33 133.89 ?  602 SO4 A O1  1 
HETATM 7603 O  O2  . SO4 D 3 .   ? 0.000   -0.000  17.197  0.33 134.34 ?  602 SO4 A O2  1 
HETATM 7604 O  O3  . SO4 D 3 .   ? 0.922   -0.995  19.114  0.33 133.89 ?  602 SO4 A O3  1 
HETATM 7605 O  O4  . SO4 D 3 .   ? 0.400   1.295   19.114  0.33 133.85 ?  602 SO4 A O4  1 
HETATM 7606 S  S   . SO4 E 3 .   ? -23.777 13.025  -7.187  0.80 126.47 ?  603 SO4 A S   1 
HETATM 7607 O  O1  . SO4 E 3 .   ? -22.509 13.654  -6.925  0.80 125.40 ?  603 SO4 A O1  1 
HETATM 7608 O  O2  . SO4 E 3 .   ? -23.980 12.949  -8.607  0.80 122.90 ?  603 SO4 A O2  1 
HETATM 7609 O  O3  . SO4 E 3 .   ? -23.785 11.702  -6.629  0.80 122.34 ?  603 SO4 A O3  1 
HETATM 7610 O  O4  . SO4 E 3 .   ? -24.830 13.797  -6.585  0.80 125.19 ?  603 SO4 A O4  1 
HETATM 7611 C  C1A A EL5 F 2 .   ? -68.067 -9.911  -29.693 0.40 72.46  ?  601 EL5 B C1A 1 
HETATM 7612 C  C1A B EL5 F 2 .   ? -68.168 -10.185 -29.574 0.60 75.72  ?  601 EL5 B C1A 1 
HETATM 7613 C  C1B A EL5 F 2 .   ? -65.644 -13.013 -27.630 0.40 72.96  ?  601 EL5 B C1B 1 
HETATM 7614 C  C1B B EL5 F 2 .   ? -66.016 -13.335 -27.291 0.60 77.04  ?  601 EL5 B C1B 1 
HETATM 7615 O  O1B A EL5 F 2 .   ? -66.014 -16.912 -21.867 0.40 77.15  ?  601 EL5 B O1B 1 
HETATM 7616 O  O1B B EL5 F 2 .   ? -63.487 -16.941 -22.296 0.60 82.36  ?  601 EL5 B O1B 1 
HETATM 7617 C  C1C A EL5 F 2 .   ? -69.116 -15.423 -26.523 0.40 74.01  ?  601 EL5 B C1C 1 
HETATM 7618 C  C1C B EL5 F 2 .   ? -69.613 -15.689 -26.495 0.60 81.80  ?  601 EL5 B C1C 1 
HETATM 7619 O  O1C A EL5 F 2 .   ? -70.613 -17.220 -21.619 0.40 68.41  ?  601 EL5 B O1C 1 
HETATM 7620 O  O1C B EL5 F 2 .   ? -72.341 -16.342 -22.249 0.60 77.58  ?  601 EL5 B O1C 1 
HETATM 7621 C  C1D A EL5 F 2 .   ? -73.423 -14.256 -27.913 0.40 73.62  ?  601 EL5 B C1D 1 
HETATM 7622 C  C1D B EL5 F 2 .   ? -73.442 -13.906 -28.689 0.60 83.71  ?  601 EL5 B C1D 1 
HETATM 7623 C  C2A A EL5 F 2 .   ? -66.931 -9.393  -30.282 0.40 72.65  ?  601 EL5 B C2A 1 
HETATM 7624 C  C2A B EL5 F 2 .   ? -66.981 -9.682  -30.067 0.60 75.28  ?  601 EL5 B C2A 1 
HETATM 7625 C  C2B A EL5 F 2 .   ? -64.730 -13.709 -26.849 0.40 72.67  ?  601 EL5 B C2B 1 
HETATM 7626 C  C2B B EL5 F 2 .   ? -65.196 -13.998 -26.385 0.60 77.11  ?  601 EL5 B C2B 1 
HETATM 7627 O  O2B A EL5 F 2 .   ? -64.238 -17.390 -23.084 0.40 77.58  ?  601 EL5 B O2B 1 
HETATM 7628 O  O2B B EL5 F 2 .   ? -65.457 -16.328 -21.527 0.60 83.14  ?  601 EL5 B O2B 1 
HETATM 7629 C  C2C A EL5 F 2 .   ? -70.075 -16.320 -26.074 0.40 73.89  ?  601 EL5 B C2C 1 
HETATM 7630 C  C2C B EL5 F 2 .   ? -70.628 -16.599 -26.221 0.60 82.49  ?  601 EL5 B C2C 1 
HETATM 7631 O  O2C A EL5 F 2 .   ? -69.150 -18.556 -22.583 0.40 65.21  ?  601 EL5 B O2C 1 
HETATM 7632 O  O2C B EL5 F 2 .   ? -72.887 -16.297 -24.368 0.60 71.87  ?  601 EL5 B O2C 1 
HETATM 7633 C  C2D A EL5 F 2 .   ? -74.437 -13.624 -28.620 0.40 74.00  ?  601 EL5 B C2D 1 
HETATM 7634 C  C2D B EL5 F 2 .   ? -74.618 -14.211 -28.001 0.60 83.52  ?  601 EL5 B C2D 1 
HETATM 7635 C  C3A A EL5 F 2 .   ? -65.768 -10.026 -29.901 0.40 72.67  ?  601 EL5 B C3A 1 
HETATM 7636 C  C3A B EL5 F 2 .   ? -65.853 -10.337 -29.602 0.60 74.80  ?  601 EL5 B C3A 1 
HETATM 7637 C  C3B A EL5 F 2 .   ? -65.438 -14.698 -26.179 0.40 73.45  ?  601 EL5 B C3B 1 
HETATM 7638 C  C3B B EL5 F 2 .   ? -65.977 -14.959 -25.751 0.60 77.73  ?  601 EL5 B C3B 1 
HETATM 7639 C  C3C A EL5 F 2 .   ? -71.272 -16.000 -26.678 0.40 73.55  ?  601 EL5 B C3C 1 
HETATM 7640 C  C3C B EL5 F 2 .   ? -71.705 -16.287 -27.018 0.60 82.10  ?  601 EL5 B C3C 1 
HETATM 7641 C  C3D A EL5 F 2 .   ? -75.640 -13.924 -27.995 0.40 74.41  ?  601 EL5 B C3D 1 
HETATM 7642 C  C3D B EL5 F 2 .   ? -75.655 -13.455 -28.534 0.60 85.24  ?  601 EL5 B C3D 1 
HETATM 7643 C  C4A A EL5 F 2 .   ? -66.211 -11.033 -29.052 0.40 72.66  ?  601 EL5 B C4A 1 
HETATM 7644 C  C4A B EL5 F 2 .   ? -66.388 -11.335 -28.785 0.60 75.96  ?  601 EL5 B C4A 1 
HETATM 7645 C  C4B A EL5 F 2 .   ? -66.750 -14.593 -26.611 0.40 72.85  ?  601 EL5 B C4B 1 
HETATM 7646 C  C4B B EL5 F 2 .   ? -67.240 -14.873 -26.324 0.60 77.97  ?  601 EL5 B C4B 1 
HETATM 7647 C  C4C A EL5 F 2 .   ? -71.074 -14.896 -27.499 0.40 73.26  ?  601 EL5 B C4C 1 
HETATM 7648 C  C4C B EL5 F 2 .   ? -71.383 -15.203 -27.826 0.60 81.02  ?  601 EL5 B C4C 1 
HETATM 7649 C  C4D A EL5 F 2 .   ? -75.355 -14.733 -26.903 0.40 74.83  ?  601 EL5 B C4D 1 
HETATM 7650 C  C4D B EL5 F 2 .   ? -75.119 -12.665 -29.540 0.60 86.63  ?  601 EL5 B C4D 1 
HETATM 7651 C  CAA A EL5 F 2 .   ? -64.476 -9.802  -30.401 0.40 73.32  ?  601 EL5 B CAA 1 
HETATM 7652 C  CAA B EL5 F 2 .   ? -64.489 -10.138 -29.962 0.60 75.00  ?  601 EL5 B CAA 1 
HETATM 7653 C  CAB A EL5 F 2 .   ? -64.935 -15.700 -25.181 0.40 74.49  ?  601 EL5 B CAB 1 
HETATM 7654 C  CAB B EL5 F 2 .   ? -65.576 -15.931 -24.677 0.60 79.63  ?  601 EL5 B CAB 1 
HETATM 7655 C  CAC A EL5 F 2 .   ? -69.811 -17.448 -25.117 0.40 73.07  ?  601 EL5 B CAC 1 
HETATM 7656 C  CAC B EL5 F 2 .   ? -70.586 -17.724 -25.224 0.60 83.01  ?  601 EL5 B CAC 1 
HETATM 7657 C  CAD A EL5 F 2 .   ? -76.927 -13.522 -28.372 0.40 74.39  ?  601 EL5 B CAD 1 
HETATM 7658 C  CAD B EL5 F 2 .   ? -77.004 -13.488 -28.122 0.60 84.72  ?  601 EL5 B CAD 1 
HETATM 7659 C  CBA A EL5 F 2 .   ? -64.244 -8.897  -31.343 0.40 74.50  ?  601 EL5 B CBA 1 
HETATM 7660 C  CBA B EL5 F 2 .   ? -64.012 -9.316  -30.919 0.60 75.44  ?  601 EL5 B CBA 1 
HETATM 7661 C  CBB A EL5 F 2 .   ? -65.640 -15.615 -23.825 0.40 75.05  ?  601 EL5 B CBB 1 
HETATM 7662 C  CBB B EL5 F 2 .   ? -64.708 -15.352 -23.561 0.60 80.71  ?  601 EL5 B CBB 1 
HETATM 7663 C  CBC A EL5 F 2 .   ? -70.802 -17.544 -23.967 0.40 72.60  ?  601 EL5 B CBC 1 
HETATM 7664 C  CBC B EL5 F 2 .   ? -70.801 -17.316 -23.768 0.60 83.09  ?  601 EL5 B CBC 1 
HETATM 7665 C  CBD A EL5 F 2 .   ? -77.228 -12.828 -29.455 0.40 74.48  ?  601 EL5 B CBD 1 
HETATM 7666 C  CBD B EL5 F 2 .   ? -78.018 -12.815 -28.636 0.60 84.49  ?  601 EL5 B CBD 1 
HETATM 7667 C  CGB A EL5 F 2 .   ? -65.270 -16.723 -22.854 0.40 76.96  ?  601 EL5 B CGB 1 
HETATM 7668 C  CGB B EL5 F 2 .   ? -64.538 -16.278 -22.373 0.60 82.18  ?  601 EL5 B CGB 1 
HETATM 7669 C  CGC A EL5 F 2 .   ? -70.139 -17.793 -22.623 0.40 70.06  ?  601 EL5 B CGC 1 
HETATM 7670 C  CGC B EL5 F 2 .   ? -72.109 -16.601 -23.447 0.60 79.43  ?  601 EL5 B CGC 1 
HETATM 7671 C  CHB A EL5 F 2 .   ? -65.346 -11.961 -28.488 0.40 73.16  ?  601 EL5 B CHB 1 
HETATM 7672 C  CHB B EL5 F 2 .   ? -65.623 -12.301 -28.139 0.60 76.93  ?  601 EL5 B CHB 1 
HETATM 7673 C  CHC A EL5 F 2 .   ? -67.776 -15.412 -26.167 0.40 73.48  ?  601 EL5 B CHC 1 
HETATM 7674 C  CHC B EL5 F 2 .   ? -68.331 -15.658 -25.959 0.60 80.57  ?  601 EL5 B CHC 1 
HETATM 7675 C  CHD A EL5 F 2 .   ? -72.074 -14.268 -28.228 0.40 73.34  ?  601 EL5 B CHD 1 
HETATM 7676 C  CHD B EL5 F 2 .   ? -72.142 -14.417 -28.685 0.60 82.02  ?  601 EL5 B CHD 1 
HETATM 7677 C  CMA A EL5 F 2 .   ? -66.957 -8.238  -31.240 0.40 72.26  ?  601 EL5 B CMA 1 
HETATM 7678 C  CMA B EL5 F 2 .   ? -66.945 -8.521  -31.016 0.60 74.67  ?  601 EL5 B CMA 1 
HETATM 7679 C  CMB A EL5 F 2 .   ? -63.263 -13.421 -26.719 0.40 72.14  ?  601 EL5 B CMB 1 
HETATM 7680 C  CMB B EL5 F 2 .   ? -63.746 -13.706 -26.116 0.60 76.86  ?  601 EL5 B CMB 1 
HETATM 7681 C  CMC A EL5 F 2 .   ? -72.580 -16.695 -26.472 0.40 73.96  ?  601 EL5 B CMC 1 
HETATM 7682 C  CMC B EL5 F 2 .   ? -72.987 -17.044 -27.037 0.60 83.88  ?  601 EL5 B CMC 1 
HETATM 7683 C  CMD A EL5 F 2 .   ? -74.272 -12.794 -29.860 0.40 74.35  ?  601 EL5 B CMD 1 
HETATM 7684 C  CMD B EL5 F 2 .   ? -74.847 -15.184 -26.884 0.60 84.25  ?  601 EL5 B CMD 1 
HETATM 7685 N  NA  A EL5 F 2 .   ? -67.603 -10.960 -28.909 0.40 73.40  ?  601 EL5 B NA  1 
HETATM 7686 N  NA  B EL5 F 2 .   ? -67.784 -11.238 -28.758 0.60 77.09  ?  601 EL5 B NA  1 
HETATM 7687 O  OA  A EL5 F 2 .   ? -69.211 -9.552  -29.818 0.40 71.35  ?  601 EL5 B OA  1 
HETATM 7688 O  OA  B EL5 F 2 .   ? -69.295 -9.816  -29.795 0.60 74.56  ?  601 EL5 B OA  1 
HETATM 7689 N  NB  A EL5 F 2 .   ? -66.883 -13.585 -27.524 0.40 72.84  ?  601 EL5 B NB  1 
HETATM 7690 N  NB  B EL5 F 2 .   ? -67.264 -13.900 -27.285 0.60 76.76  ?  601 EL5 B NB  1 
HETATM 7691 N  NC  A EL5 F 2 .   ? -69.739 -14.572 -27.413 0.40 74.25  ?  601 EL5 B NC  1 
HETATM 7692 N  NC  B EL5 F 2 .   ? -70.088 -14.862 -27.491 0.60 81.80  ?  601 EL5 B NC  1 
HETATM 7693 N  ND  A EL5 F 2 .   ? -73.996 -14.931 -26.861 0.40 74.22  ?  601 EL5 B ND  1 
HETATM 7694 N  ND  B EL5 F 2 .   ? -73.777 -12.944 -29.624 0.60 85.38  ?  601 EL5 B ND  1 
HETATM 7695 O  OD  A EL5 F 2 .   ? -76.150 -15.213 -26.112 0.40 76.38  ?  601 EL5 B OD  1 
HETATM 7696 O  OD  B EL5 F 2 .   ? -75.703 -11.857 -30.250 0.60 88.35  ?  601 EL5 B OD  1 
HETATM 7697 S  S   . SO4 G 3 .   ? -78.149 -29.932 -37.883 1.00 145.94 ?  602 SO4 B S   1 
HETATM 7698 O  O1  . SO4 G 3 .   ? -78.946 -29.852 -39.076 1.00 146.71 ?  602 SO4 B O1  1 
HETATM 7699 O  O2  . SO4 G 3 .   ? -76.816 -29.467 -38.166 1.00 145.21 ?  602 SO4 B O2  1 
HETATM 7700 O  O3  . SO4 G 3 .   ? -78.092 -31.296 -37.433 1.00 149.31 ?  602 SO4 B O3  1 
HETATM 7701 O  O4  . SO4 G 3 .   ? -78.742 -29.115 -36.857 1.00 141.26 ?  602 SO4 B O4  1 
HETATM 7702 S  S   . SO4 H 3 .   ? -92.049 -53.144 -63.653 0.33 137.97 ?  603 SO4 B S   1 
HETATM 7703 O  O1  . SO4 H 3 .   ? -90.700 -53.290 -63.173 0.33 135.54 ?  603 SO4 B O1  1 
HETATM 7704 O  O2  . SO4 H 3 .   ? -92.049 -53.145 -65.092 0.33 136.05 ?  603 SO4 B O2  1 
HETATM 7705 O  O3  . SO4 H 3 .   ? -92.849 -54.240 -63.173 0.33 135.54 ?  603 SO4 B O3  1 
HETATM 7706 O  O4  . SO4 H 3 .   ? -92.597 -51.904 -63.173 0.33 135.54 ?  603 SO4 B O4  1 
HETATM 7707 S  S   . SO4 I 3 .   ? -82.717 -25.248 -39.721 1.00 135.58 ?  604 SO4 B S   1 
HETATM 7708 O  O1  . SO4 I 3 .   ? -81.764 -24.341 -40.305 1.00 132.81 ?  604 SO4 B O1  1 
HETATM 7709 O  O2  . SO4 I 3 .   ? -82.434 -26.587 -40.165 1.00 128.48 ?  604 SO4 B O2  1 
HETATM 7710 O  O3  . SO4 I 3 .   ? -84.044 -24.875 -40.132 1.00 137.26 ?  604 SO4 B O3  1 
HETATM 7711 O  O4  . SO4 I 3 .   ? -82.627 -25.184 -38.284 1.00 128.07 ?  604 SO4 B O4  1 
HETATM 7712 CL CL  . CL  J 4 .   ? -85.429 -33.332 -37.519 1.00 97.66  ?  605 CL  B CL  1 
HETATM 7713 O  O   . HOH K 5 .   ? -42.677 11.046  -26.244 1.00 52.98  ?  701 HOH A O   1 
HETATM 7714 O  O   . HOH K 5 .   ? -28.141 5.368   14.438  1.00 56.77  ?  702 HOH A O   1 
HETATM 7715 O  O   . HOH K 5 .   ? -26.644 34.513  21.508  1.00 81.59  ?  703 HOH A O   1 
HETATM 7716 O  O   . HOH K 5 .   ? -15.411 12.202  -7.247  1.00 73.61  ?  704 HOH A O   1 
HETATM 7717 O  O   . HOH K 5 .   ? -27.627 21.138  -3.347  1.00 60.88  ?  705 HOH A O   1 
HETATM 7718 O  O   . HOH K 5 .   ? -36.355 21.170  -23.912 1.00 52.19  ?  706 HOH A O   1 
HETATM 7719 O  O   . HOH K 5 .   ? -8.007  21.081  23.690  1.00 58.61  ?  707 HOH A O   1 
HETATM 7720 O  O   . HOH K 5 .   ? -29.620 12.800  -8.833  1.00 51.18  ?  708 HOH A O   1 
HETATM 7721 O  O   . HOH K 5 .   ? -3.706  9.335   29.656  1.00 77.39  ?  709 HOH A O   1 
HETATM 7722 O  O   . HOH K 5 .   ? -33.026 28.202  -12.202 0.50 31.05  ?  710 HOH A O   1 
HETATM 7723 O  O   . HOH K 5 .   ? -25.870 23.408  3.595   1.00 52.32  ?  711 HOH A O   1 
HETATM 7724 O  O   . HOH K 5 .   ? -37.097 4.466   -53.044 1.00 73.84  ?  712 HOH A O   1 
HETATM 7725 O  O   . HOH K 5 .   ? -40.314 24.458  -18.512 0.50 23.40  ?  713 HOH A O   1 
HETATM 7726 O  O   . HOH K 5 .   ? -17.356 22.529  -26.288 0.50 25.63  ?  714 HOH A O   1 
HETATM 7727 O  O   . HOH K 5 .   ? -14.858 9.931   4.797   1.00 60.04  ?  715 HOH A O   1 
HETATM 7728 O  O   . HOH K 5 .   ? -36.545 8.101   -10.889 1.00 62.44  ?  716 HOH A O   1 
HETATM 7729 O  O   . HOH K 5 .   ? -30.977 3.654   -23.985 1.00 67.33  ?  717 HOH A O   1 
HETATM 7730 O  O   . HOH K 5 .   ? -28.302 15.333  -37.843 0.50 31.36  ?  718 HOH A O   1 
HETATM 7731 O  O   . HOH K 5 .   ? -53.232 7.405   -19.709 1.00 62.50  ?  719 HOH A O   1 
HETATM 7732 O  O   . HOH K 5 .   ? -38.579 8.596   -37.502 1.00 54.08  ?  720 HOH A O   1 
HETATM 7733 O  O   . HOH K 5 .   ? -18.778 30.293  -22.260 0.50 34.97  ?  721 HOH A O   1 
HETATM 7734 O  O   . HOH K 5 .   ? -15.147 0.621   19.834  1.00 60.03  ?  722 HOH A O   1 
HETATM 7735 O  O   . HOH K 5 .   ? -19.002 23.247  -16.612 1.00 60.58  ?  723 HOH A O   1 
HETATM 7736 O  O   . HOH K 5 .   ? -7.537  9.042   -14.709 1.00 74.51  ?  724 HOH A O   1 
HETATM 7737 O  O   . HOH K 5 .   ? -32.983 26.344  10.633  1.00 58.24  ?  725 HOH A O   1 
HETATM 7738 O  O   . HOH K 5 .   ? -22.186 20.207  -7.177  1.00 59.84  ?  726 HOH A O   1 
HETATM 7739 O  O   . HOH K 5 .   ? -12.394 15.422  -8.444  1.00 60.23  ?  727 HOH A O   1 
HETATM 7740 O  O   . HOH K 5 .   ? -49.613 -8.402  -29.238 1.00 76.38  ?  728 HOH A O   1 
HETATM 7741 O  O   . HOH K 5 .   ? -12.484 3.399   -5.992  1.00 67.71  ?  729 HOH A O   1 
HETATM 7742 O  O   . HOH K 5 .   ? -16.519 27.006  21.544  1.00 61.25  ?  730 HOH A O   1 
HETATM 7743 O  O   . HOH K 5 .   ? -20.086 29.957  14.701  1.00 65.22  ?  731 HOH A O   1 
HETATM 7744 O  O   . HOH K 5 .   ? -13.928 -0.800  -11.690 1.00 73.16  ?  732 HOH A O   1 
HETATM 7745 O  O   . HOH K 5 .   ? -18.732 27.460  -21.784 1.00 57.45  ?  733 HOH A O   1 
HETATM 7746 O  O   . HOH K 5 .   ? -34.954 21.951  -21.769 1.00 50.72  ?  734 HOH A O   1 
HETATM 7747 O  O   . HOH K 5 .   ? -27.720 -0.872  -10.331 1.00 65.04  ?  735 HOH A O   1 
HETATM 7748 O  O   . HOH K 5 .   ? -22.612 19.116  -5.086  1.00 66.60  ?  736 HOH A O   1 
HETATM 7749 O  O   . HOH K 5 .   ? -3.428  11.952  21.497  1.00 59.72  ?  737 HOH A O   1 
HETATM 7750 O  O   . HOH K 5 .   ? -28.742 -1.376  -25.950 1.00 69.42  ?  738 HOH A O   1 
HETATM 7751 O  O   . HOH K 5 .   ? -9.051  10.604  -18.647 1.00 66.36  ?  739 HOH A O   1 
HETATM 7752 O  O   . HOH K 5 .   ? -24.443 10.563  -3.556  1.00 67.69  ?  740 HOH A O   1 
HETATM 7753 O  O   . HOH K 5 .   ? -18.555 12.434  -34.746 1.00 69.62  ?  741 HOH A O   1 
HETATM 7754 O  O   . HOH K 5 .   ? -52.163 5.461   -18.202 1.00 73.34  ?  742 HOH A O   1 
HETATM 7755 O  O   . HOH K 5 .   ? -45.700 -2.137  -53.134 1.00 81.37  ?  743 HOH A O   1 
HETATM 7756 O  O   . HOH K 5 .   ? -20.272 9.552   -1.232  1.00 67.83  ?  744 HOH A O   1 
HETATM 7757 O  O   . HOH K 5 .   ? -21.664 16.561  -4.847  1.00 63.90  ?  745 HOH A O   1 
HETATM 7758 O  O   . HOH K 5 .   ? -20.014 31.444  20.486  1.00 60.03  ?  746 HOH A O   1 
HETATM 7759 O  O   . HOH K 5 .   ? -24.463 9.678   -0.895  1.00 63.56  ?  747 HOH A O   1 
HETATM 7760 O  O   . HOH K 5 .   ? -53.669 12.692  -17.045 1.00 74.87  ?  748 HOH A O   1 
HETATM 7761 O  O   . HOH K 5 .   ? -27.264 1.105   28.402  1.00 70.28  ?  749 HOH A O   1 
HETATM 7762 O  O   . HOH K 5 .   ? -12.762 26.698  24.171  1.00 70.95  ?  750 HOH A O   1 
HETATM 7763 O  O   . HOH K 5 .   ? -29.400 1.186   -36.797 1.00 85.15  ?  751 HOH A O   1 
HETATM 7764 O  O   . HOH K 5 .   ? -56.077 12.932  -15.965 1.00 69.46  ?  752 HOH A O   1 
HETATM 7765 O  O   . HOH K 5 .   ? -27.867 0.610   -34.544 1.00 74.57  ?  753 HOH A O   1 
HETATM 7766 O  O   . HOH L 5 .   ? -61.723 -10.807 -27.800 1.00 60.83  ?  701 HOH B O   1 
HETATM 7767 O  O   . HOH L 5 .   ? -79.418 -2.732  -22.624 1.00 75.78  ?  702 HOH B O   1 
HETATM 7768 O  O   . HOH L 5 .   ? -58.693 -15.217 -31.180 1.00 73.75  ?  703 HOH B O   1 
HETATM 7769 O  O   . HOH L 5 .   ? -70.378 -19.009 -19.792 1.00 54.47  ?  704 HOH B O   1 
HETATM 7770 O  O   . HOH L 5 .   ? -68.427 -26.013 -5.498  1.00 63.50  ?  705 HOH B O   1 
HETATM 7771 O  O   . HOH L 5 .   ? -69.847 -11.854 -26.877 0.50 37.14  ?  706 HOH B O   1 
HETATM 7772 O  O   . HOH L 5 .   ? -92.239 -24.761 -69.223 1.00 65.71  ?  707 HOH B O   1 
HETATM 7773 O  O   . HOH L 5 .   ? -77.843 -12.764 -33.098 0.60 61.84  ?  708 HOH B O   1 
HETATM 7774 O  O   . HOH L 5 .   ? -55.115 -24.296 -17.393 1.00 59.35  ?  709 HOH B O   1 
HETATM 7775 O  O   . HOH L 5 .   ? -54.099 -30.719 4.874   1.00 80.60  ?  710 HOH B O   1 
HETATM 7776 O  O   . HOH L 5 .   ? -53.586 -15.638 -16.516 0.50 31.55  ?  711 HOH B O   1 
HETATM 7777 O  O   . HOH L 5 .   ? -50.396 -23.568 -16.992 1.00 72.07  ?  712 HOH B O   1 
HETATM 7778 O  O   . HOH L 5 .   ? -64.546 -27.652 -34.194 1.00 50.27  ?  713 HOH B O   1 
HETATM 7779 O  O   . HOH L 5 .   ? -83.448 -34.492 -75.295 1.00 74.84  ?  714 HOH B O   1 
HETATM 7780 O  O   . HOH L 5 .   ? -60.721 -14.994 -34.454 1.00 59.31  ?  715 HOH B O   1 
HETATM 7781 O  O   . HOH L 5 .   ? -45.024 -29.587 -0.570  1.00 62.87  ?  716 HOH B O   1 
HETATM 7782 O  O   . HOH L 5 .   ? -67.477 -37.331 -59.413 1.00 66.33  ?  717 HOH B O   1 
HETATM 7783 O  O   . HOH L 5 .   ? -95.061 -33.545 -53.977 1.00 64.61  ?  718 HOH B O   1 
HETATM 7784 O  O   . HOH L 5 .   ? -74.537 -33.363 -44.874 1.00 74.80  ?  719 HOH B O   1 
HETATM 7785 O  O   . HOH L 5 .   ? -72.633 -24.177 -51.278 1.00 60.52  ?  720 HOH B O   1 
HETATM 7786 O  O   . HOH L 5 .   ? -44.737 -4.813  -23.042 1.00 74.28  ?  721 HOH B O   1 
HETATM 7787 O  O   . HOH L 5 .   ? -76.125 -31.564 -40.897 1.00 74.51  ?  722 HOH B O   1 
HETATM 7788 O  O   . HOH L 5 .   ? -92.879 -46.344 -60.503 1.00 72.12  ?  723 HOH B O   1 
HETATM 7789 O  O   . HOH L 5 .   ? -70.467 -13.588 -71.419 1.00 83.08  ?  724 HOH B O   1 
HETATM 7790 O  O   . HOH L 5 .   ? -51.846 -28.175 -25.576 1.00 76.05  ?  725 HOH B O   1 
HETATM 7791 O  O   . HOH L 5 .   ? -56.530 -8.000  -37.435 1.00 58.47  ?  726 HOH B O   1 
HETATM 7792 O  O   . HOH L 5 .   ? -87.157 -41.537 -46.473 1.00 69.59  ?  727 HOH B O   1 
HETATM 7793 O  O   . HOH L 5 .   ? -79.511 -34.712 -44.089 1.00 59.30  ?  728 HOH B O   1 
HETATM 7794 O  O   . HOH L 5 .   ? -89.739 -16.031 -65.874 1.00 69.17  ?  729 HOH B O   1 
HETATM 7795 O  O   . HOH L 5 .   ? -92.398 -2.681  -29.216 1.00 71.14  ?  730 HOH B O   1 
HETATM 7796 O  O   . HOH L 5 .   ? -75.784 -41.268 -7.277  1.00 77.46  ?  731 HOH B O   1 
HETATM 7797 O  O   . HOH L 5 .   ? -90.826 -42.617 -54.609 1.00 70.64  ?  732 HOH B O   1 
HETATM 7798 O  O   . HOH L 5 .   ? -89.456 -23.568 -20.493 1.00 65.06  ?  733 HOH B O   1 
HETATM 7799 O  O   . HOH L 5 .   ? -51.378 -30.107 -27.831 1.00 70.73  ?  734 HOH B O   1 
HETATM 7800 O  O   . HOH L 5 .   ? -53.354 -31.935 -29.301 1.00 66.47  ?  735 HOH B O   1 
# 
