data_8RJ1
# 
_entry.id   8RJ1 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.401 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8RJ1         pdb_00008rj1 10.2210/pdb8rj1/pdb 
WWPDB D_1292135502 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2025-01-15 
2 'Structure model' 1 1 2025-02-05 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
3 2 'Structure model' '_citation.title'                   
4 2 'Structure model' '_citation.year'                    
5 2 'Structure model' '_citation_author.name'             
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8RJ1 
_pdbx_database_status.recvd_initial_deposition_date   2023-12-19 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              d.b.janssen@rug.nl 
_pdbx_contact_author.name_first         Dick 
_pdbx_contact_author.name_last          Janssen 
_pdbx_contact_author.name_mi            B. 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-0834-2043 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Capra, N.'            1 0000-0002-2898-6479 
'Thunnissen, A.M.W.H.' 2 0000-0002-1915-9850 
'Janssen, D.B.'        3 0000-0002-0834-2043 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Acs Catalysis' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2155-5435 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            15 
_citation.language                  ? 
_citation.page_first                928 
_citation.page_last                 938 
_citation.title                     
'Bioinformatics and Computationally Supported Redesign of Aspartase for beta-Alanine Synthesis by Acrylic Acid Hydroamination.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/acscatal.4c05525 
_citation.pdbx_database_id_PubMed   39839848 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Gran-Scheuch, A.'   1 ? 
primary 'Wijma, H.J.'        2 ? 
primary 'Capra, N.'          3 ? 
primary 'van Beek, H.L.'     4 ? 
primary 'Trajkovic, M.'      5 ? 
primary 'Baldenius, K.'      6 ? 
primary 'Breuer, M.'         7 ? 
primary 'Thunnissen, A.W.H.' 8 ? 
primary 'Janssen, D.B.'      9 ? 
# 
_entity.id                         1 
_entity.type                       polymer 
_entity.src_method                 man 
_entity.pdbx_description           'Aspartate ammonia lyase' 
_entity.formula_weight             52626.148 
_entity.pdbx_number_of_molecules   2 
_entity.pdbx_ec                    4.3.1.1 
_entity.pdbx_mutation              'T187I, M321I, K324M, N326C, A424S,I431T' 
_entity.pdbx_fragment              ? 
_entity.details                    ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MQQEQSYRIEKDFLGEKKIPADAYYGIQTLRATENFPITGYRIHEELIRALAMVKKAAALANMETKRLPAHIGEAIVAAC
DEIIAGQWHDQFIVDPIQGGAGTSINMNANEVIANRALEIMGKKKGDYFHVRPNSDVNMSQSTNDAFPTAVHIAVLTLLD
HLLETMERMRDAFAEKAKAFDPYIKMGRIHLQDAVPIRLGQEFEAYTRVIERDIQRIKQSRGHLYEINMGATAVGTGLNA
DPRYIESVVKHLREISGYPLVGAENLVDATQNTDAYTEVSAALKVCMMNMSKIANDLRLMASGPRAGLGEITLPARQPGS
SIIPGMVCPVMAEVINQIAFQVIGNDHTICLASEAGQLELNVMEPVLVFNLLQSISIMNNGFRVFTEYCVKGIEANEEKM
KEYVEKSVGVITAVNPHIGYEVASRIAREATLTGQSVRDLCRKYDVLSDEELDLILDPYEMTHPGIAGASLLERD
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MQQEQSYRIEKDFLGEKKIPADAYYGIQTLRATENFPITGYRIHEELIRALAMVKKAAALANMETKRLPAHIGEAIVAAC
DEIIAGQWHDQFIVDPIQGGAGTSINMNANEVIANRALEIMGKKKGDYFHVRPNSDVNMSQSTNDAFPTAVHIAVLTLLD
HLLETMERMRDAFAEKAKAFDPYIKMGRIHLQDAVPIRLGQEFEAYTRVIERDIQRIKQSRGHLYEINMGATAVGTGLNA
DPRYIESVVKHLREISGYPLVGAENLVDATQNTDAYTEVSAALKVCMMNMSKIANDLRLMASGPRAGLGEITLPARQPGS
SIIPGMVCPVMAEVINQIAFQVIGNDHTICLASEAGQLELNVMEPVLVFNLLQSISIMNNGFRVFTEYCVKGIEANEEKM
KEYVEKSVGVITAVNPHIGYEVASRIAREATLTGQSVRDLCRKYDVLSDEELDLILDPYEMTHPGIAGASLLERD
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLN n 
1 3   GLN n 
1 4   GLU n 
1 5   GLN n 
1 6   SER n 
1 7   TYR n 
1 8   ARG n 
1 9   ILE n 
1 10  GLU n 
1 11  LYS n 
1 12  ASP n 
1 13  PHE n 
1 14  LEU n 
1 15  GLY n 
1 16  GLU n 
1 17  LYS n 
1 18  LYS n 
1 19  ILE n 
1 20  PRO n 
1 21  ALA n 
1 22  ASP n 
1 23  ALA n 
1 24  TYR n 
1 25  TYR n 
1 26  GLY n 
1 27  ILE n 
1 28  GLN n 
1 29  THR n 
1 30  LEU n 
1 31  ARG n 
1 32  ALA n 
1 33  THR n 
1 34  GLU n 
1 35  ASN n 
1 36  PHE n 
1 37  PRO n 
1 38  ILE n 
1 39  THR n 
1 40  GLY n 
1 41  TYR n 
1 42  ARG n 
1 43  ILE n 
1 44  HIS n 
1 45  GLU n 
1 46  GLU n 
1 47  LEU n 
1 48  ILE n 
1 49  ARG n 
1 50  ALA n 
1 51  LEU n 
1 52  ALA n 
1 53  MET n 
1 54  VAL n 
1 55  LYS n 
1 56  LYS n 
1 57  ALA n 
1 58  ALA n 
1 59  ALA n 
1 60  LEU n 
1 61  ALA n 
1 62  ASN n 
1 63  MET n 
1 64  GLU n 
1 65  THR n 
1 66  LYS n 
1 67  ARG n 
1 68  LEU n 
1 69  PRO n 
1 70  ALA n 
1 71  HIS n 
1 72  ILE n 
1 73  GLY n 
1 74  GLU n 
1 75  ALA n 
1 76  ILE n 
1 77  VAL n 
1 78  ALA n 
1 79  ALA n 
1 80  CYS n 
1 81  ASP n 
1 82  GLU n 
1 83  ILE n 
1 84  ILE n 
1 85  ALA n 
1 86  GLY n 
1 87  GLN n 
1 88  TRP n 
1 89  HIS n 
1 90  ASP n 
1 91  GLN n 
1 92  PHE n 
1 93  ILE n 
1 94  VAL n 
1 95  ASP n 
1 96  PRO n 
1 97  ILE n 
1 98  GLN n 
1 99  GLY n 
1 100 GLY n 
1 101 ALA n 
1 102 GLY n 
1 103 THR n 
1 104 SER n 
1 105 ILE n 
1 106 ASN n 
1 107 MET n 
1 108 ASN n 
1 109 ALA n 
1 110 ASN n 
1 111 GLU n 
1 112 VAL n 
1 113 ILE n 
1 114 ALA n 
1 115 ASN n 
1 116 ARG n 
1 117 ALA n 
1 118 LEU n 
1 119 GLU n 
1 120 ILE n 
1 121 MET n 
1 122 GLY n 
1 123 LYS n 
1 124 LYS n 
1 125 LYS n 
1 126 GLY n 
1 127 ASP n 
1 128 TYR n 
1 129 PHE n 
1 130 HIS n 
1 131 VAL n 
1 132 ARG n 
1 133 PRO n 
1 134 ASN n 
1 135 SER n 
1 136 ASP n 
1 137 VAL n 
1 138 ASN n 
1 139 MET n 
1 140 SER n 
1 141 GLN n 
1 142 SER n 
1 143 THR n 
1 144 ASN n 
1 145 ASP n 
1 146 ALA n 
1 147 PHE n 
1 148 PRO n 
1 149 THR n 
1 150 ALA n 
1 151 VAL n 
1 152 HIS n 
1 153 ILE n 
1 154 ALA n 
1 155 VAL n 
1 156 LEU n 
1 157 THR n 
1 158 LEU n 
1 159 LEU n 
1 160 ASP n 
1 161 HIS n 
1 162 LEU n 
1 163 LEU n 
1 164 GLU n 
1 165 THR n 
1 166 MET n 
1 167 GLU n 
1 168 ARG n 
1 169 MET n 
1 170 ARG n 
1 171 ASP n 
1 172 ALA n 
1 173 PHE n 
1 174 ALA n 
1 175 GLU n 
1 176 LYS n 
1 177 ALA n 
1 178 LYS n 
1 179 ALA n 
1 180 PHE n 
1 181 ASP n 
1 182 PRO n 
1 183 TYR n 
1 184 ILE n 
1 185 LYS n 
1 186 MET n 
1 187 GLY n 
1 188 ARG n 
1 189 ILE n 
1 190 HIS n 
1 191 LEU n 
1 192 GLN n 
1 193 ASP n 
1 194 ALA n 
1 195 VAL n 
1 196 PRO n 
1 197 ILE n 
1 198 ARG n 
1 199 LEU n 
1 200 GLY n 
1 201 GLN n 
1 202 GLU n 
1 203 PHE n 
1 204 GLU n 
1 205 ALA n 
1 206 TYR n 
1 207 THR n 
1 208 ARG n 
1 209 VAL n 
1 210 ILE n 
1 211 GLU n 
1 212 ARG n 
1 213 ASP n 
1 214 ILE n 
1 215 GLN n 
1 216 ARG n 
1 217 ILE n 
1 218 LYS n 
1 219 GLN n 
1 220 SER n 
1 221 ARG n 
1 222 GLY n 
1 223 HIS n 
1 224 LEU n 
1 225 TYR n 
1 226 GLU n 
1 227 ILE n 
1 228 ASN n 
1 229 MET n 
1 230 GLY n 
1 231 ALA n 
1 232 THR n 
1 233 ALA n 
1 234 VAL n 
1 235 GLY n 
1 236 THR n 
1 237 GLY n 
1 238 LEU n 
1 239 ASN n 
1 240 ALA n 
1 241 ASP n 
1 242 PRO n 
1 243 ARG n 
1 244 TYR n 
1 245 ILE n 
1 246 GLU n 
1 247 SER n 
1 248 VAL n 
1 249 VAL n 
1 250 LYS n 
1 251 HIS n 
1 252 LEU n 
1 253 ARG n 
1 254 GLU n 
1 255 ILE n 
1 256 SER n 
1 257 GLY n 
1 258 TYR n 
1 259 PRO n 
1 260 LEU n 
1 261 VAL n 
1 262 GLY n 
1 263 ALA n 
1 264 GLU n 
1 265 ASN n 
1 266 LEU n 
1 267 VAL n 
1 268 ASP n 
1 269 ALA n 
1 270 THR n 
1 271 GLN n 
1 272 ASN n 
1 273 THR n 
1 274 ASP n 
1 275 ALA n 
1 276 TYR n 
1 277 THR n 
1 278 GLU n 
1 279 VAL n 
1 280 SER n 
1 281 ALA n 
1 282 ALA n 
1 283 LEU n 
1 284 LYS n 
1 285 VAL n 
1 286 CYS n 
1 287 MET n 
1 288 MET n 
1 289 ASN n 
1 290 MET n 
1 291 SER n 
1 292 LYS n 
1 293 ILE n 
1 294 ALA n 
1 295 ASN n 
1 296 ASP n 
1 297 LEU n 
1 298 ARG n 
1 299 LEU n 
1 300 MET n 
1 301 ALA n 
1 302 SER n 
1 303 GLY n 
1 304 PRO n 
1 305 ARG n 
1 306 ALA n 
1 307 GLY n 
1 308 LEU n 
1 309 GLY n 
1 310 GLU n 
1 311 ILE n 
1 312 THR n 
1 313 LEU n 
1 314 PRO n 
1 315 ALA n 
1 316 ARG n 
1 317 GLN n 
1 318 PRO n 
1 319 GLY n 
1 320 SER n 
1 321 SER n 
1 322 ILE n 
1 323 ILE n 
1 324 PRO n 
1 325 GLY n 
1 326 MET n 
1 327 VAL n 
1 328 CYS n 
1 329 PRO n 
1 330 VAL n 
1 331 MET n 
1 332 ALA n 
1 333 GLU n 
1 334 VAL n 
1 335 ILE n 
1 336 ASN n 
1 337 GLN n 
1 338 ILE n 
1 339 ALA n 
1 340 PHE n 
1 341 GLN n 
1 342 VAL n 
1 343 ILE n 
1 344 GLY n 
1 345 ASN n 
1 346 ASP n 
1 347 HIS n 
1 348 THR n 
1 349 ILE n 
1 350 CYS n 
1 351 LEU n 
1 352 ALA n 
1 353 SER n 
1 354 GLU n 
1 355 ALA n 
1 356 GLY n 
1 357 GLN n 
1 358 LEU n 
1 359 GLU n 
1 360 LEU n 
1 361 ASN n 
1 362 VAL n 
1 363 MET n 
1 364 GLU n 
1 365 PRO n 
1 366 VAL n 
1 367 LEU n 
1 368 VAL n 
1 369 PHE n 
1 370 ASN n 
1 371 LEU n 
1 372 LEU n 
1 373 GLN n 
1 374 SER n 
1 375 ILE n 
1 376 SER n 
1 377 ILE n 
1 378 MET n 
1 379 ASN n 
1 380 ASN n 
1 381 GLY n 
1 382 PHE n 
1 383 ARG n 
1 384 VAL n 
1 385 PHE n 
1 386 THR n 
1 387 GLU n 
1 388 TYR n 
1 389 CYS n 
1 390 VAL n 
1 391 LYS n 
1 392 GLY n 
1 393 ILE n 
1 394 GLU n 
1 395 ALA n 
1 396 ASN n 
1 397 GLU n 
1 398 GLU n 
1 399 LYS n 
1 400 MET n 
1 401 LYS n 
1 402 GLU n 
1 403 TYR n 
1 404 VAL n 
1 405 GLU n 
1 406 LYS n 
1 407 SER n 
1 408 VAL n 
1 409 GLY n 
1 410 VAL n 
1 411 ILE n 
1 412 THR n 
1 413 ALA n 
1 414 VAL n 
1 415 ASN n 
1 416 PRO n 
1 417 HIS n 
1 418 ILE n 
1 419 GLY n 
1 420 TYR n 
1 421 GLU n 
1 422 VAL n 
1 423 ALA n 
1 424 SER n 
1 425 ARG n 
1 426 ILE n 
1 427 ALA n 
1 428 ARG n 
1 429 GLU n 
1 430 ALA n 
1 431 THR n 
1 432 LEU n 
1 433 THR n 
1 434 GLY n 
1 435 GLN n 
1 436 SER n 
1 437 VAL n 
1 438 ARG n 
1 439 ASP n 
1 440 LEU n 
1 441 CYS n 
1 442 ARG n 
1 443 LYS n 
1 444 TYR n 
1 445 ASP n 
1 446 VAL n 
1 447 LEU n 
1 448 SER n 
1 449 ASP n 
1 450 GLU n 
1 451 GLU n 
1 452 LEU n 
1 453 ASP n 
1 454 LEU n 
1 455 ILE n 
1 456 LEU n 
1 457 ASP n 
1 458 PRO n 
1 459 TYR n 
1 460 GLU n 
1 461 MET n 
1 462 THR n 
1 463 HIS n 
1 464 PRO n 
1 465 GLY n 
1 466 ILE n 
1 467 ALA n 
1 468 GLY n 
1 469 ALA n 
1 470 SER n 
1 471 LEU n 
1 472 LEU n 
1 473 GLU n 
1 474 ARG n 
1 475 ASP n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   475 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Caenibacillus caldisaponilyticus' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     1674942 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -1  ?   ?   ?   A . n 
A 1 2   GLN 2   0   ?   ?   ?   A . n 
A 1 3   GLN 3   1   ?   ?   ?   A . n 
A 1 4   GLU 4   2   ?   ?   ?   A . n 
A 1 5   GLN 5   3   ?   ?   ?   A . n 
A 1 6   SER 6   4   ?   ?   ?   A . n 
A 1 7   TYR 7   5   5   TYR TYR A . n 
A 1 8   ARG 8   6   6   ARG ARG A . n 
A 1 9   ILE 9   7   7   ILE ILE A . n 
A 1 10  GLU 10  8   8   GLU GLU A . n 
A 1 11  LYS 11  9   9   LYS LYS A . n 
A 1 12  ASP 12  10  10  ASP ASP A . n 
A 1 13  PHE 13  11  11  PHE PHE A . n 
A 1 14  LEU 14  12  12  LEU LEU A . n 
A 1 15  GLY 15  13  13  GLY GLY A . n 
A 1 16  GLU 16  14  14  GLU GLU A . n 
A 1 17  LYS 17  15  15  LYS LYS A . n 
A 1 18  LYS 18  16  16  LYS LYS A . n 
A 1 19  ILE 19  17  17  ILE ILE A . n 
A 1 20  PRO 20  18  18  PRO PRO A . n 
A 1 21  ALA 21  19  19  ALA ALA A . n 
A 1 22  ASP 22  20  20  ASP ASP A . n 
A 1 23  ALA 23  21  21  ALA ALA A . n 
A 1 24  TYR 24  22  22  TYR TYR A . n 
A 1 25  TYR 25  23  23  TYR TYR A . n 
A 1 26  GLY 26  24  24  GLY GLY A . n 
A 1 27  ILE 27  25  25  ILE ILE A . n 
A 1 28  GLN 28  26  26  GLN GLN A . n 
A 1 29  THR 29  27  27  THR THR A . n 
A 1 30  LEU 30  28  28  LEU LEU A . n 
A 1 31  ARG 31  29  29  ARG ARG A . n 
A 1 32  ALA 32  30  30  ALA ALA A . n 
A 1 33  THR 33  31  31  THR THR A . n 
A 1 34  GLU 34  32  32  GLU GLU A . n 
A 1 35  ASN 35  33  33  ASN ASN A . n 
A 1 36  PHE 36  34  34  PHE PHE A . n 
A 1 37  PRO 37  35  35  PRO PRO A . n 
A 1 38  ILE 38  36  36  ILE ILE A . n 
A 1 39  THR 39  37  37  THR THR A . n 
A 1 40  GLY 40  38  38  GLY GLY A . n 
A 1 41  TYR 41  39  39  TYR TYR A . n 
A 1 42  ARG 42  40  40  ARG ARG A . n 
A 1 43  ILE 43  41  41  ILE ILE A . n 
A 1 44  HIS 44  42  42  HIS HIS A . n 
A 1 45  GLU 45  43  43  GLU GLU A . n 
A 1 46  GLU 46  44  44  GLU GLU A . n 
A 1 47  LEU 47  45  45  LEU LEU A . n 
A 1 48  ILE 48  46  46  ILE ILE A . n 
A 1 49  ARG 49  47  47  ARG ARG A . n 
A 1 50  ALA 50  48  48  ALA ALA A . n 
A 1 51  LEU 51  49  49  LEU LEU A . n 
A 1 52  ALA 52  50  50  ALA ALA A . n 
A 1 53  MET 53  51  51  MET MET A . n 
A 1 54  VAL 54  52  52  VAL VAL A . n 
A 1 55  LYS 55  53  53  LYS LYS A . n 
A 1 56  LYS 56  54  54  LYS LYS A . n 
A 1 57  ALA 57  55  55  ALA ALA A . n 
A 1 58  ALA 58  56  56  ALA ALA A . n 
A 1 59  ALA 59  57  57  ALA ALA A . n 
A 1 60  LEU 60  58  58  LEU LEU A . n 
A 1 61  ALA 61  59  59  ALA ALA A . n 
A 1 62  ASN 62  60  60  ASN ASN A . n 
A 1 63  MET 63  61  61  MET MET A . n 
A 1 64  GLU 64  62  62  GLU GLU A . n 
A 1 65  THR 65  63  63  THR THR A . n 
A 1 66  LYS 66  64  64  LYS LYS A . n 
A 1 67  ARG 67  65  65  ARG ARG A . n 
A 1 68  LEU 68  66  66  LEU LEU A . n 
A 1 69  PRO 69  67  67  PRO PRO A . n 
A 1 70  ALA 70  68  68  ALA ALA A . n 
A 1 71  HIS 71  69  69  HIS HIS A . n 
A 1 72  ILE 72  70  70  ILE ILE A . n 
A 1 73  GLY 73  71  71  GLY GLY A . n 
A 1 74  GLU 74  72  72  GLU GLU A . n 
A 1 75  ALA 75  73  73  ALA ALA A . n 
A 1 76  ILE 76  74  74  ILE ILE A . n 
A 1 77  VAL 77  75  75  VAL VAL A . n 
A 1 78  ALA 78  76  76  ALA ALA A . n 
A 1 79  ALA 79  77  77  ALA ALA A . n 
A 1 80  CYS 80  78  78  CYS CYS A . n 
A 1 81  ASP 81  79  79  ASP ASP A . n 
A 1 82  GLU 82  80  80  GLU GLU A . n 
A 1 83  ILE 83  81  81  ILE ILE A . n 
A 1 84  ILE 84  82  82  ILE ILE A . n 
A 1 85  ALA 85  83  83  ALA ALA A . n 
A 1 86  GLY 86  84  84  GLY GLY A . n 
A 1 87  GLN 87  85  85  GLN GLN A . n 
A 1 88  TRP 88  86  86  TRP TRP A . n 
A 1 89  HIS 89  87  87  HIS HIS A . n 
A 1 90  ASP 90  88  88  ASP ASP A . n 
A 1 91  GLN 91  89  89  GLN GLN A . n 
A 1 92  PHE 92  90  90  PHE PHE A . n 
A 1 93  ILE 93  91  91  ILE ILE A . n 
A 1 94  VAL 94  92  92  VAL VAL A . n 
A 1 95  ASP 95  93  93  ASP ASP A . n 
A 1 96  PRO 96  94  94  PRO PRO A . n 
A 1 97  ILE 97  95  95  ILE ILE A . n 
A 1 98  GLN 98  96  96  GLN GLN A . n 
A 1 99  GLY 99  97  97  GLY GLY A . n 
A 1 100 GLY 100 98  98  GLY GLY A . n 
A 1 101 ALA 101 99  99  ALA ALA A . n 
A 1 102 GLY 102 100 100 GLY GLY A . n 
A 1 103 THR 103 101 101 THR THR A . n 
A 1 104 SER 104 102 102 SER SER A . n 
A 1 105 ILE 105 103 103 ILE ILE A . n 
A 1 106 ASN 106 104 104 ASN ASN A . n 
A 1 107 MET 107 105 105 MET MET A . n 
A 1 108 ASN 108 106 106 ASN ASN A . n 
A 1 109 ALA 109 107 107 ALA ALA A . n 
A 1 110 ASN 110 108 108 ASN ASN A . n 
A 1 111 GLU 111 109 109 GLU GLU A . n 
A 1 112 VAL 112 110 110 VAL VAL A . n 
A 1 113 ILE 113 111 111 ILE ILE A . n 
A 1 114 ALA 114 112 112 ALA ALA A . n 
A 1 115 ASN 115 113 113 ASN ASN A . n 
A 1 116 ARG 116 114 114 ARG ARG A . n 
A 1 117 ALA 117 115 115 ALA ALA A . n 
A 1 118 LEU 118 116 116 LEU LEU A . n 
A 1 119 GLU 119 117 117 GLU GLU A . n 
A 1 120 ILE 120 118 118 ILE ILE A . n 
A 1 121 MET 121 119 119 MET MET A . n 
A 1 122 GLY 122 120 120 GLY GLY A . n 
A 1 123 LYS 123 121 121 LYS LYS A . n 
A 1 124 LYS 124 122 122 LYS LYS A . n 
A 1 125 LYS 125 123 123 LYS LYS A . n 
A 1 126 GLY 126 124 124 GLY GLY A . n 
A 1 127 ASP 127 125 125 ASP ASP A . n 
A 1 128 TYR 128 126 126 TYR TYR A . n 
A 1 129 PHE 129 127 127 PHE PHE A . n 
A 1 130 HIS 130 128 128 HIS HIS A . n 
A 1 131 VAL 131 129 129 VAL VAL A . n 
A 1 132 ARG 132 130 130 ARG ARG A . n 
A 1 133 PRO 133 131 131 PRO PRO A . n 
A 1 134 ASN 134 132 132 ASN ASN A . n 
A 1 135 SER 135 133 133 SER SER A . n 
A 1 136 ASP 136 134 134 ASP ASP A . n 
A 1 137 VAL 137 135 135 VAL VAL A . n 
A 1 138 ASN 138 136 136 ASN ASN A . n 
A 1 139 MET 139 137 137 MET MET A . n 
A 1 140 SER 140 138 138 SER SER A . n 
A 1 141 GLN 141 139 139 GLN GLN A . n 
A 1 142 SER 142 140 140 SER SER A . n 
A 1 143 THR 143 141 141 THR THR A . n 
A 1 144 ASN 144 142 142 ASN ASN A . n 
A 1 145 ASP 145 143 143 ASP ASP A . n 
A 1 146 ALA 146 144 144 ALA ALA A . n 
A 1 147 PHE 147 145 145 PHE PHE A . n 
A 1 148 PRO 148 146 146 PRO PRO A . n 
A 1 149 THR 149 147 147 THR THR A . n 
A 1 150 ALA 150 148 148 ALA ALA A . n 
A 1 151 VAL 151 149 149 VAL VAL A . n 
A 1 152 HIS 152 150 150 HIS HIS A . n 
A 1 153 ILE 153 151 151 ILE ILE A . n 
A 1 154 ALA 154 152 152 ALA ALA A . n 
A 1 155 VAL 155 153 153 VAL VAL A . n 
A 1 156 LEU 156 154 154 LEU LEU A . n 
A 1 157 THR 157 155 155 THR THR A . n 
A 1 158 LEU 158 156 156 LEU LEU A . n 
A 1 159 LEU 159 157 157 LEU LEU A . n 
A 1 160 ASP 160 158 158 ASP ASP A . n 
A 1 161 HIS 161 159 159 HIS HIS A . n 
A 1 162 LEU 162 160 160 LEU LEU A . n 
A 1 163 LEU 163 161 161 LEU LEU A . n 
A 1 164 GLU 164 162 162 GLU GLU A . n 
A 1 165 THR 165 163 163 THR THR A . n 
A 1 166 MET 166 164 164 MET MET A . n 
A 1 167 GLU 167 165 165 GLU GLU A . n 
A 1 168 ARG 168 166 166 ARG ARG A . n 
A 1 169 MET 169 167 167 MET MET A . n 
A 1 170 ARG 170 168 168 ARG ARG A . n 
A 1 171 ASP 171 169 169 ASP ASP A . n 
A 1 172 ALA 172 170 170 ALA ALA A . n 
A 1 173 PHE 173 171 171 PHE PHE A . n 
A 1 174 ALA 174 172 172 ALA ALA A . n 
A 1 175 GLU 175 173 173 GLU GLU A . n 
A 1 176 LYS 176 174 174 LYS LYS A . n 
A 1 177 ALA 177 175 175 ALA ALA A . n 
A 1 178 LYS 178 176 176 LYS LYS A . n 
A 1 179 ALA 179 177 177 ALA ALA A . n 
A 1 180 PHE 180 178 178 PHE PHE A . n 
A 1 181 ASP 181 179 179 ASP ASP A . n 
A 1 182 PRO 182 180 180 PRO PRO A . n 
A 1 183 TYR 183 181 181 TYR TYR A . n 
A 1 184 ILE 184 182 182 ILE ILE A . n 
A 1 185 LYS 185 183 183 LYS LYS A . n 
A 1 186 MET 186 184 184 MET MET A . n 
A 1 187 GLY 187 185 185 GLY GLY A . n 
A 1 188 ARG 188 186 186 ARG ARG A . n 
A 1 189 ILE 189 187 187 ILE ILE A . n 
A 1 190 HIS 190 188 188 HIS HIS A . n 
A 1 191 LEU 191 189 189 LEU LEU A . n 
A 1 192 GLN 192 190 190 GLN GLN A . n 
A 1 193 ASP 193 191 191 ASP ASP A . n 
A 1 194 ALA 194 192 192 ALA ALA A . n 
A 1 195 VAL 195 193 193 VAL VAL A . n 
A 1 196 PRO 196 194 194 PRO PRO A . n 
A 1 197 ILE 197 195 195 ILE ILE A . n 
A 1 198 ARG 198 196 196 ARG ARG A . n 
A 1 199 LEU 199 197 197 LEU LEU A . n 
A 1 200 GLY 200 198 198 GLY GLY A . n 
A 1 201 GLN 201 199 199 GLN GLN A . n 
A 1 202 GLU 202 200 200 GLU GLU A . n 
A 1 203 PHE 203 201 201 PHE PHE A . n 
A 1 204 GLU 204 202 202 GLU GLU A . n 
A 1 205 ALA 205 203 203 ALA ALA A . n 
A 1 206 TYR 206 204 204 TYR TYR A . n 
A 1 207 THR 207 205 205 THR THR A . n 
A 1 208 ARG 208 206 206 ARG ARG A . n 
A 1 209 VAL 209 207 207 VAL VAL A . n 
A 1 210 ILE 210 208 208 ILE ILE A . n 
A 1 211 GLU 211 209 209 GLU GLU A . n 
A 1 212 ARG 212 210 210 ARG ARG A . n 
A 1 213 ASP 213 211 211 ASP ASP A . n 
A 1 214 ILE 214 212 212 ILE ILE A . n 
A 1 215 GLN 215 213 213 GLN GLN A . n 
A 1 216 ARG 216 214 214 ARG ARG A . n 
A 1 217 ILE 217 215 215 ILE ILE A . n 
A 1 218 LYS 218 216 216 LYS LYS A . n 
A 1 219 GLN 219 217 217 GLN GLN A . n 
A 1 220 SER 220 218 218 SER SER A . n 
A 1 221 ARG 221 219 219 ARG ARG A . n 
A 1 222 GLY 222 220 220 GLY GLY A . n 
A 1 223 HIS 223 221 221 HIS HIS A . n 
A 1 224 LEU 224 222 222 LEU LEU A . n 
A 1 225 TYR 225 223 223 TYR TYR A . n 
A 1 226 GLU 226 224 224 GLU GLU A . n 
A 1 227 ILE 227 225 225 ILE ILE A . n 
A 1 228 ASN 228 226 226 ASN ASN A . n 
A 1 229 MET 229 227 227 MET MET A . n 
A 1 230 GLY 230 228 228 GLY GLY A . n 
A 1 231 ALA 231 229 229 ALA ALA A . n 
A 1 232 THR 232 230 230 THR THR A . n 
A 1 233 ALA 233 231 231 ALA ALA A . n 
A 1 234 VAL 234 232 232 VAL VAL A . n 
A 1 235 GLY 235 233 233 GLY GLY A . n 
A 1 236 THR 236 234 234 THR THR A . n 
A 1 237 GLY 237 235 235 GLY GLY A . n 
A 1 238 LEU 238 236 236 LEU LEU A . n 
A 1 239 ASN 239 237 237 ASN ASN A . n 
A 1 240 ALA 240 238 238 ALA ALA A . n 
A 1 241 ASP 241 239 239 ASP ASP A . n 
A 1 242 PRO 242 240 240 PRO PRO A . n 
A 1 243 ARG 243 241 241 ARG ARG A . n 
A 1 244 TYR 244 242 242 TYR TYR A . n 
A 1 245 ILE 245 243 243 ILE ILE A . n 
A 1 246 GLU 246 244 244 GLU GLU A . n 
A 1 247 SER 247 245 245 SER SER A . n 
A 1 248 VAL 248 246 246 VAL VAL A . n 
A 1 249 VAL 249 247 247 VAL VAL A . n 
A 1 250 LYS 250 248 248 LYS LYS A . n 
A 1 251 HIS 251 249 249 HIS HIS A . n 
A 1 252 LEU 252 250 250 LEU LEU A . n 
A 1 253 ARG 253 251 251 ARG ARG A . n 
A 1 254 GLU 254 252 252 GLU GLU A . n 
A 1 255 ILE 255 253 253 ILE ILE A . n 
A 1 256 SER 256 254 254 SER SER A . n 
A 1 257 GLY 257 255 255 GLY GLY A . n 
A 1 258 TYR 258 256 256 TYR TYR A . n 
A 1 259 PRO 259 257 257 PRO PRO A . n 
A 1 260 LEU 260 258 258 LEU LEU A . n 
A 1 261 VAL 261 259 259 VAL VAL A . n 
A 1 262 GLY 262 260 260 GLY GLY A . n 
A 1 263 ALA 263 261 261 ALA ALA A . n 
A 1 264 GLU 264 262 262 GLU GLU A . n 
A 1 265 ASN 265 263 263 ASN ASN A . n 
A 1 266 LEU 266 264 264 LEU LEU A . n 
A 1 267 VAL 267 265 265 VAL VAL A . n 
A 1 268 ASP 268 266 266 ASP ASP A . n 
A 1 269 ALA 269 267 267 ALA ALA A . n 
A 1 270 THR 270 268 268 THR THR A . n 
A 1 271 GLN 271 269 269 GLN GLN A . n 
A 1 272 ASN 272 270 270 ASN ASN A . n 
A 1 273 THR 273 271 271 THR THR A . n 
A 1 274 ASP 274 272 272 ASP ASP A . n 
A 1 275 ALA 275 273 273 ALA ALA A . n 
A 1 276 TYR 276 274 274 TYR TYR A . n 
A 1 277 THR 277 275 275 THR THR A . n 
A 1 278 GLU 278 276 276 GLU GLU A . n 
A 1 279 VAL 279 277 277 VAL VAL A . n 
A 1 280 SER 280 278 278 SER SER A . n 
A 1 281 ALA 281 279 279 ALA ALA A . n 
A 1 282 ALA 282 280 280 ALA ALA A . n 
A 1 283 LEU 283 281 281 LEU LEU A . n 
A 1 284 LYS 284 282 282 LYS LYS A . n 
A 1 285 VAL 285 283 283 VAL VAL A . n 
A 1 286 CYS 286 284 284 CYS CYS A . n 
A 1 287 MET 287 285 285 MET MET A . n 
A 1 288 MET 288 286 286 MET MET A . n 
A 1 289 ASN 289 287 287 ASN ASN A . n 
A 1 290 MET 290 288 288 MET MET A . n 
A 1 291 SER 291 289 289 SER SER A . n 
A 1 292 LYS 292 290 290 LYS LYS A . n 
A 1 293 ILE 293 291 291 ILE ILE A . n 
A 1 294 ALA 294 292 292 ALA ALA A . n 
A 1 295 ASN 295 293 293 ASN ASN A . n 
A 1 296 ASP 296 294 294 ASP ASP A . n 
A 1 297 LEU 297 295 295 LEU LEU A . n 
A 1 298 ARG 298 296 296 ARG ARG A . n 
A 1 299 LEU 299 297 297 LEU LEU A . n 
A 1 300 MET 300 298 298 MET MET A . n 
A 1 301 ALA 301 299 299 ALA ALA A . n 
A 1 302 SER 302 300 300 SER SER A . n 
A 1 303 GLY 303 301 301 GLY GLY A . n 
A 1 304 PRO 304 302 302 PRO PRO A . n 
A 1 305 ARG 305 303 303 ARG ARG A . n 
A 1 306 ALA 306 304 304 ALA ALA A . n 
A 1 307 GLY 307 305 305 GLY GLY A . n 
A 1 308 LEU 308 306 306 LEU LEU A . n 
A 1 309 GLY 309 307 307 GLY GLY A . n 
A 1 310 GLU 310 308 308 GLU GLU A . n 
A 1 311 ILE 311 309 309 ILE ILE A . n 
A 1 312 THR 312 310 310 THR THR A . n 
A 1 313 LEU 313 311 311 LEU LEU A . n 
A 1 314 PRO 314 312 312 PRO PRO A . n 
A 1 315 ALA 315 313 313 ALA ALA A . n 
A 1 316 ARG 316 314 314 ARG ARG A . n 
A 1 317 GLN 317 315 315 GLN GLN A . n 
A 1 318 PRO 318 316 316 PRO PRO A . n 
A 1 319 GLY 319 317 317 GLY GLY A . n 
A 1 320 SER 320 318 318 SER SER A . n 
A 1 321 SER 321 319 319 SER SER A . n 
A 1 322 ILE 322 320 320 ILE ILE A . n 
A 1 323 ILE 323 321 321 ILE ILE A . n 
A 1 324 PRO 324 322 322 PRO PRO A . n 
A 1 325 GLY 325 323 323 GLY GLY A . n 
A 1 326 MET 326 324 324 MET MET A . n 
A 1 327 VAL 327 325 325 VAL VAL A . n 
A 1 328 CYS 328 326 326 CYS CYS A . n 
A 1 329 PRO 329 327 327 PRO PRO A . n 
A 1 330 VAL 330 328 328 VAL VAL A . n 
A 1 331 MET 331 329 329 MET MET A . n 
A 1 332 ALA 332 330 330 ALA ALA A . n 
A 1 333 GLU 333 331 331 GLU GLU A . n 
A 1 334 VAL 334 332 332 VAL VAL A . n 
A 1 335 ILE 335 333 333 ILE ILE A . n 
A 1 336 ASN 336 334 334 ASN ASN A . n 
A 1 337 GLN 337 335 335 GLN GLN A . n 
A 1 338 ILE 338 336 336 ILE ILE A . n 
A 1 339 ALA 339 337 337 ALA ALA A . n 
A 1 340 PHE 340 338 338 PHE PHE A . n 
A 1 341 GLN 341 339 339 GLN GLN A . n 
A 1 342 VAL 342 340 340 VAL VAL A . n 
A 1 343 ILE 343 341 341 ILE ILE A . n 
A 1 344 GLY 344 342 342 GLY GLY A . n 
A 1 345 ASN 345 343 343 ASN ASN A . n 
A 1 346 ASP 346 344 344 ASP ASP A . n 
A 1 347 HIS 347 345 345 HIS HIS A . n 
A 1 348 THR 348 346 346 THR THR A . n 
A 1 349 ILE 349 347 347 ILE ILE A . n 
A 1 350 CYS 350 348 348 CYS CYS A . n 
A 1 351 LEU 351 349 349 LEU LEU A . n 
A 1 352 ALA 352 350 350 ALA ALA A . n 
A 1 353 SER 353 351 351 SER SER A . n 
A 1 354 GLU 354 352 352 GLU GLU A . n 
A 1 355 ALA 355 353 353 ALA ALA A . n 
A 1 356 GLY 356 354 354 GLY GLY A . n 
A 1 357 GLN 357 355 355 GLN GLN A . n 
A 1 358 LEU 358 356 356 LEU LEU A . n 
A 1 359 GLU 359 357 357 GLU GLU A . n 
A 1 360 LEU 360 358 358 LEU LEU A . n 
A 1 361 ASN 361 359 359 ASN ASN A . n 
A 1 362 VAL 362 360 360 VAL VAL A . n 
A 1 363 MET 363 361 361 MET MET A . n 
A 1 364 GLU 364 362 362 GLU GLU A . n 
A 1 365 PRO 365 363 363 PRO PRO A . n 
A 1 366 VAL 366 364 364 VAL VAL A . n 
A 1 367 LEU 367 365 365 LEU LEU A . n 
A 1 368 VAL 368 366 366 VAL VAL A . n 
A 1 369 PHE 369 367 367 PHE PHE A . n 
A 1 370 ASN 370 368 368 ASN ASN A . n 
A 1 371 LEU 371 369 369 LEU LEU A . n 
A 1 372 LEU 372 370 370 LEU LEU A . n 
A 1 373 GLN 373 371 371 GLN GLN A . n 
A 1 374 SER 374 372 372 SER SER A . n 
A 1 375 ILE 375 373 373 ILE ILE A . n 
A 1 376 SER 376 374 374 SER SER A . n 
A 1 377 ILE 377 375 375 ILE ILE A . n 
A 1 378 MET 378 376 376 MET MET A . n 
A 1 379 ASN 379 377 377 ASN ASN A . n 
A 1 380 ASN 380 378 378 ASN ASN A . n 
A 1 381 GLY 381 379 379 GLY GLY A . n 
A 1 382 PHE 382 380 380 PHE PHE A . n 
A 1 383 ARG 383 381 381 ARG ARG A . n 
A 1 384 VAL 384 382 382 VAL VAL A . n 
A 1 385 PHE 385 383 383 PHE PHE A . n 
A 1 386 THR 386 384 384 THR THR A . n 
A 1 387 GLU 387 385 385 GLU GLU A . n 
A 1 388 TYR 388 386 386 TYR TYR A . n 
A 1 389 CYS 389 387 387 CYS CYS A . n 
A 1 390 VAL 390 388 388 VAL VAL A . n 
A 1 391 LYS 391 389 389 LYS LYS A . n 
A 1 392 GLY 392 390 390 GLY GLY A . n 
A 1 393 ILE 393 391 391 ILE ILE A . n 
A 1 394 GLU 394 392 392 GLU GLU A . n 
A 1 395 ALA 395 393 393 ALA ALA A . n 
A 1 396 ASN 396 394 394 ASN ASN A . n 
A 1 397 GLU 397 395 395 GLU GLU A . n 
A 1 398 GLU 398 396 396 GLU GLU A . n 
A 1 399 LYS 399 397 397 LYS LYS A . n 
A 1 400 MET 400 398 398 MET MET A . n 
A 1 401 LYS 401 399 399 LYS LYS A . n 
A 1 402 GLU 402 400 400 GLU GLU A . n 
A 1 403 TYR 403 401 401 TYR TYR A . n 
A 1 404 VAL 404 402 402 VAL VAL A . n 
A 1 405 GLU 405 403 403 GLU GLU A . n 
A 1 406 LYS 406 404 404 LYS LYS A . n 
A 1 407 SER 407 405 405 SER SER A . n 
A 1 408 VAL 408 406 406 VAL VAL A . n 
A 1 409 GLY 409 407 407 GLY GLY A . n 
A 1 410 VAL 410 408 408 VAL VAL A . n 
A 1 411 ILE 411 409 409 ILE ILE A . n 
A 1 412 THR 412 410 410 THR THR A . n 
A 1 413 ALA 413 411 411 ALA ALA A . n 
A 1 414 VAL 414 412 412 VAL VAL A . n 
A 1 415 ASN 415 413 413 ASN ASN A . n 
A 1 416 PRO 416 414 414 PRO PRO A . n 
A 1 417 HIS 417 415 415 HIS HIS A . n 
A 1 418 ILE 418 416 416 ILE ILE A . n 
A 1 419 GLY 419 417 417 GLY GLY A . n 
A 1 420 TYR 420 418 418 TYR TYR A . n 
A 1 421 GLU 421 419 419 GLU GLU A . n 
A 1 422 VAL 422 420 420 VAL VAL A . n 
A 1 423 ALA 423 421 421 ALA ALA A . n 
A 1 424 SER 424 422 422 SER SER A . n 
A 1 425 ARG 425 423 423 ARG ARG A . n 
A 1 426 ILE 426 424 424 ILE ILE A . n 
A 1 427 ALA 427 425 425 ALA ALA A . n 
A 1 428 ARG 428 426 426 ARG ARG A . n 
A 1 429 GLU 429 427 427 GLU GLU A . n 
A 1 430 ALA 430 428 428 ALA ALA A . n 
A 1 431 THR 431 429 429 THR THR A . n 
A 1 432 LEU 432 430 430 LEU LEU A . n 
A 1 433 THR 433 431 431 THR THR A . n 
A 1 434 GLY 434 432 432 GLY GLY A . n 
A 1 435 GLN 435 433 433 GLN GLN A . n 
A 1 436 SER 436 434 434 SER SER A . n 
A 1 437 VAL 437 435 435 VAL VAL A . n 
A 1 438 ARG 438 436 436 ARG ARG A . n 
A 1 439 ASP 439 437 437 ASP ASP A . n 
A 1 440 LEU 440 438 438 LEU LEU A . n 
A 1 441 CYS 441 439 439 CYS CYS A . n 
A 1 442 ARG 442 440 440 ARG ARG A . n 
A 1 443 LYS 443 441 441 LYS LYS A . n 
A 1 444 TYR 444 442 442 TYR TYR A . n 
A 1 445 ASP 445 443 443 ASP ASP A . n 
A 1 446 VAL 446 444 444 VAL VAL A . n 
A 1 447 LEU 447 445 445 LEU LEU A . n 
A 1 448 SER 448 446 446 SER SER A . n 
A 1 449 ASP 449 447 447 ASP ASP A . n 
A 1 450 GLU 450 448 448 GLU GLU A . n 
A 1 451 GLU 451 449 449 GLU GLU A . n 
A 1 452 LEU 452 450 450 LEU LEU A . n 
A 1 453 ASP 453 451 451 ASP ASP A . n 
A 1 454 LEU 454 452 452 LEU LEU A . n 
A 1 455 ILE 455 453 453 ILE ILE A . n 
A 1 456 LEU 456 454 454 LEU LEU A . n 
A 1 457 ASP 457 455 455 ASP ASP A . n 
A 1 458 PRO 458 456 456 PRO PRO A . n 
A 1 459 TYR 459 457 457 TYR TYR A . n 
A 1 460 GLU 460 458 458 GLU GLU A . n 
A 1 461 MET 461 459 459 MET MET A . n 
A 1 462 THR 462 460 460 THR THR A . n 
A 1 463 HIS 463 461 461 HIS HIS A . n 
A 1 464 PRO 464 462 462 PRO PRO A . n 
A 1 465 GLY 465 463 463 GLY GLY A . n 
A 1 466 ILE 466 464 464 ILE ILE A . n 
A 1 467 ALA 467 465 465 ALA ALA A . n 
A 1 468 GLY 468 466 466 GLY ALA A . n 
A 1 469 ALA 469 467 ?   ?   ?   A . n 
A 1 470 SER 470 468 ?   ?   ?   A . n 
A 1 471 LEU 471 469 ?   ?   ?   A . n 
A 1 472 LEU 472 470 ?   ?   ?   A . n 
A 1 473 GLU 473 471 ?   ?   ?   A . n 
A 1 474 ARG 474 472 ?   ?   ?   A . n 
A 1 475 ASP 475 473 ?   ?   ?   A . n 
B 1 1   MET 1   -1  ?   ?   ?   B . n 
B 1 2   GLN 2   0   ?   ?   ?   B . n 
B 1 3   GLN 3   1   ?   ?   ?   B . n 
B 1 4   GLU 4   2   ?   ?   ?   B . n 
B 1 5   GLN 5   3   ?   ?   ?   B . n 
B 1 6   SER 6   4   ?   ?   ?   B . n 
B 1 7   TYR 7   5   5   TYR TYR B . n 
B 1 8   ARG 8   6   6   ARG ARG B . n 
B 1 9   ILE 9   7   7   ILE ILE B . n 
B 1 10  GLU 10  8   8   GLU GLU B . n 
B 1 11  LYS 11  9   9   LYS LYS B . n 
B 1 12  ASP 12  10  10  ASP ASP B . n 
B 1 13  PHE 13  11  11  PHE PHE B . n 
B 1 14  LEU 14  12  12  LEU LEU B . n 
B 1 15  GLY 15  13  13  GLY GLY B . n 
B 1 16  GLU 16  14  14  GLU GLU B . n 
B 1 17  LYS 17  15  15  LYS LYS B . n 
B 1 18  LYS 18  16  16  LYS LYS B . n 
B 1 19  ILE 19  17  17  ILE ILE B . n 
B 1 20  PRO 20  18  18  PRO PRO B . n 
B 1 21  ALA 21  19  19  ALA ALA B . n 
B 1 22  ASP 22  20  20  ASP ASP B . n 
B 1 23  ALA 23  21  21  ALA ALA B . n 
B 1 24  TYR 24  22  22  TYR TYR B . n 
B 1 25  TYR 25  23  23  TYR TYR B . n 
B 1 26  GLY 26  24  24  GLY GLY B . n 
B 1 27  ILE 27  25  25  ILE ILE B . n 
B 1 28  GLN 28  26  26  GLN GLN B . n 
B 1 29  THR 29  27  27  THR THR B . n 
B 1 30  LEU 30  28  28  LEU LEU B . n 
B 1 31  ARG 31  29  29  ARG ARG B . n 
B 1 32  ALA 32  30  30  ALA ALA B . n 
B 1 33  THR 33  31  31  THR THR B . n 
B 1 34  GLU 34  32  32  GLU GLU B . n 
B 1 35  ASN 35  33  33  ASN ASN B . n 
B 1 36  PHE 36  34  34  PHE PHE B . n 
B 1 37  PRO 37  35  35  PRO PRO B . n 
B 1 38  ILE 38  36  36  ILE ILE B . n 
B 1 39  THR 39  37  37  THR THR B . n 
B 1 40  GLY 40  38  38  GLY GLY B . n 
B 1 41  TYR 41  39  39  TYR TYR B . n 
B 1 42  ARG 42  40  40  ARG ARG B . n 
B 1 43  ILE 43  41  41  ILE ILE B . n 
B 1 44  HIS 44  42  42  HIS HIS B . n 
B 1 45  GLU 45  43  43  GLU GLU B . n 
B 1 46  GLU 46  44  44  GLU GLU B . n 
B 1 47  LEU 47  45  45  LEU LEU B . n 
B 1 48  ILE 48  46  46  ILE ILE B . n 
B 1 49  ARG 49  47  47  ARG ARG B . n 
B 1 50  ALA 50  48  48  ALA ALA B . n 
B 1 51  LEU 51  49  49  LEU LEU B . n 
B 1 52  ALA 52  50  50  ALA ALA B . n 
B 1 53  MET 53  51  51  MET MET B . n 
B 1 54  VAL 54  52  52  VAL VAL B . n 
B 1 55  LYS 55  53  53  LYS LYS B . n 
B 1 56  LYS 56  54  54  LYS LYS B . n 
B 1 57  ALA 57  55  55  ALA ALA B . n 
B 1 58  ALA 58  56  56  ALA ALA B . n 
B 1 59  ALA 59  57  57  ALA ALA B . n 
B 1 60  LEU 60  58  58  LEU LEU B . n 
B 1 61  ALA 61  59  59  ALA ALA B . n 
B 1 62  ASN 62  60  60  ASN ASN B . n 
B 1 63  MET 63  61  61  MET MET B . n 
B 1 64  GLU 64  62  62  GLU GLU B . n 
B 1 65  THR 65  63  63  THR THR B . n 
B 1 66  LYS 66  64  64  LYS LYS B . n 
B 1 67  ARG 67  65  65  ARG ARG B . n 
B 1 68  LEU 68  66  66  LEU LEU B . n 
B 1 69  PRO 69  67  67  PRO PRO B . n 
B 1 70  ALA 70  68  68  ALA ALA B . n 
B 1 71  HIS 71  69  69  HIS HIS B . n 
B 1 72  ILE 72  70  70  ILE ILE B . n 
B 1 73  GLY 73  71  71  GLY GLY B . n 
B 1 74  GLU 74  72  72  GLU GLU B . n 
B 1 75  ALA 75  73  73  ALA ALA B . n 
B 1 76  ILE 76  74  74  ILE ILE B . n 
B 1 77  VAL 77  75  75  VAL VAL B . n 
B 1 78  ALA 78  76  76  ALA ALA B . n 
B 1 79  ALA 79  77  77  ALA ALA B . n 
B 1 80  CYS 80  78  78  CYS CYS B . n 
B 1 81  ASP 81  79  79  ASP ASP B . n 
B 1 82  GLU 82  80  80  GLU GLU B . n 
B 1 83  ILE 83  81  81  ILE ILE B . n 
B 1 84  ILE 84  82  82  ILE ILE B . n 
B 1 85  ALA 85  83  83  ALA ALA B . n 
B 1 86  GLY 86  84  84  GLY GLY B . n 
B 1 87  GLN 87  85  85  GLN GLN B . n 
B 1 88  TRP 88  86  86  TRP TRP B . n 
B 1 89  HIS 89  87  87  HIS HIS B . n 
B 1 90  ASP 90  88  88  ASP ASP B . n 
B 1 91  GLN 91  89  89  GLN GLN B . n 
B 1 92  PHE 92  90  90  PHE PHE B . n 
B 1 93  ILE 93  91  91  ILE ILE B . n 
B 1 94  VAL 94  92  92  VAL VAL B . n 
B 1 95  ASP 95  93  93  ASP ASP B . n 
B 1 96  PRO 96  94  94  PRO PRO B . n 
B 1 97  ILE 97  95  95  ILE ILE B . n 
B 1 98  GLN 98  96  96  GLN GLN B . n 
B 1 99  GLY 99  97  97  GLY GLY B . n 
B 1 100 GLY 100 98  98  GLY GLY B . n 
B 1 101 ALA 101 99  99  ALA ALA B . n 
B 1 102 GLY 102 100 100 GLY GLY B . n 
B 1 103 THR 103 101 101 THR THR B . n 
B 1 104 SER 104 102 102 SER SER B . n 
B 1 105 ILE 105 103 103 ILE ILE B . n 
B 1 106 ASN 106 104 104 ASN ASN B . n 
B 1 107 MET 107 105 105 MET MET B . n 
B 1 108 ASN 108 106 106 ASN ASN B . n 
B 1 109 ALA 109 107 107 ALA ALA B . n 
B 1 110 ASN 110 108 108 ASN ASN B . n 
B 1 111 GLU 111 109 109 GLU GLU B . n 
B 1 112 VAL 112 110 110 VAL VAL B . n 
B 1 113 ILE 113 111 111 ILE ILE B . n 
B 1 114 ALA 114 112 112 ALA ALA B . n 
B 1 115 ASN 115 113 113 ASN ASN B . n 
B 1 116 ARG 116 114 114 ARG ARG B . n 
B 1 117 ALA 117 115 115 ALA ALA B . n 
B 1 118 LEU 118 116 116 LEU LEU B . n 
B 1 119 GLU 119 117 117 GLU GLU B . n 
B 1 120 ILE 120 118 118 ILE ILE B . n 
B 1 121 MET 121 119 119 MET MET B . n 
B 1 122 GLY 122 120 120 GLY GLY B . n 
B 1 123 LYS 123 121 121 LYS LYS B . n 
B 1 124 LYS 124 122 122 LYS LYS B . n 
B 1 125 LYS 125 123 123 LYS LYS B . n 
B 1 126 GLY 126 124 124 GLY GLY B . n 
B 1 127 ASP 127 125 125 ASP ASP B . n 
B 1 128 TYR 128 126 126 TYR TYR B . n 
B 1 129 PHE 129 127 127 PHE PHE B . n 
B 1 130 HIS 130 128 128 HIS HIS B . n 
B 1 131 VAL 131 129 129 VAL VAL B . n 
B 1 132 ARG 132 130 130 ARG ARG B . n 
B 1 133 PRO 133 131 131 PRO PRO B . n 
B 1 134 ASN 134 132 132 ASN ASN B . n 
B 1 135 SER 135 133 133 SER SER B . n 
B 1 136 ASP 136 134 134 ASP ASP B . n 
B 1 137 VAL 137 135 135 VAL VAL B . n 
B 1 138 ASN 138 136 136 ASN ASN B . n 
B 1 139 MET 139 137 137 MET MET B . n 
B 1 140 SER 140 138 138 SER SER B . n 
B 1 141 GLN 141 139 139 GLN GLN B . n 
B 1 142 SER 142 140 140 SER SER B . n 
B 1 143 THR 143 141 141 THR THR B . n 
B 1 144 ASN 144 142 142 ASN ASN B . n 
B 1 145 ASP 145 143 143 ASP ASP B . n 
B 1 146 ALA 146 144 144 ALA ALA B . n 
B 1 147 PHE 147 145 145 PHE PHE B . n 
B 1 148 PRO 148 146 146 PRO PRO B . n 
B 1 149 THR 149 147 147 THR THR B . n 
B 1 150 ALA 150 148 148 ALA ALA B . n 
B 1 151 VAL 151 149 149 VAL VAL B . n 
B 1 152 HIS 152 150 150 HIS HIS B . n 
B 1 153 ILE 153 151 151 ILE ILE B . n 
B 1 154 ALA 154 152 152 ALA ALA B . n 
B 1 155 VAL 155 153 153 VAL VAL B . n 
B 1 156 LEU 156 154 154 LEU LEU B . n 
B 1 157 THR 157 155 155 THR THR B . n 
B 1 158 LEU 158 156 156 LEU LEU B . n 
B 1 159 LEU 159 157 157 LEU LEU B . n 
B 1 160 ASP 160 158 158 ASP ASP B . n 
B 1 161 HIS 161 159 159 HIS HIS B . n 
B 1 162 LEU 162 160 160 LEU LEU B . n 
B 1 163 LEU 163 161 161 LEU LEU B . n 
B 1 164 GLU 164 162 162 GLU GLU B . n 
B 1 165 THR 165 163 163 THR THR B . n 
B 1 166 MET 166 164 164 MET MET B . n 
B 1 167 GLU 167 165 165 GLU GLU B . n 
B 1 168 ARG 168 166 166 ARG ARG B . n 
B 1 169 MET 169 167 167 MET MET B . n 
B 1 170 ARG 170 168 168 ARG ARG B . n 
B 1 171 ASP 171 169 169 ASP ASP B . n 
B 1 172 ALA 172 170 170 ALA ALA B . n 
B 1 173 PHE 173 171 171 PHE PHE B . n 
B 1 174 ALA 174 172 172 ALA ALA B . n 
B 1 175 GLU 175 173 173 GLU GLU B . n 
B 1 176 LYS 176 174 174 LYS LYS B . n 
B 1 177 ALA 177 175 175 ALA ALA B . n 
B 1 178 LYS 178 176 176 LYS LYS B . n 
B 1 179 ALA 179 177 177 ALA ALA B . n 
B 1 180 PHE 180 178 178 PHE PHE B . n 
B 1 181 ASP 181 179 179 ASP ASP B . n 
B 1 182 PRO 182 180 180 PRO PRO B . n 
B 1 183 TYR 183 181 181 TYR TYR B . n 
B 1 184 ILE 184 182 182 ILE ILE B . n 
B 1 185 LYS 185 183 183 LYS LYS B . n 
B 1 186 MET 186 184 184 MET MET B . n 
B 1 187 GLY 187 185 185 GLY GLY B . n 
B 1 188 ARG 188 186 186 ARG ARG B . n 
B 1 189 ILE 189 187 187 ILE ILE B . n 
B 1 190 HIS 190 188 188 HIS HIS B . n 
B 1 191 LEU 191 189 189 LEU LEU B . n 
B 1 192 GLN 192 190 190 GLN GLN B . n 
B 1 193 ASP 193 191 191 ASP ASP B . n 
B 1 194 ALA 194 192 192 ALA ALA B . n 
B 1 195 VAL 195 193 193 VAL VAL B . n 
B 1 196 PRO 196 194 194 PRO PRO B . n 
B 1 197 ILE 197 195 195 ILE ILE B . n 
B 1 198 ARG 198 196 196 ARG ARG B . n 
B 1 199 LEU 199 197 197 LEU LEU B . n 
B 1 200 GLY 200 198 198 GLY GLY B . n 
B 1 201 GLN 201 199 199 GLN GLN B . n 
B 1 202 GLU 202 200 200 GLU GLU B . n 
B 1 203 PHE 203 201 201 PHE PHE B . n 
B 1 204 GLU 204 202 202 GLU GLU B . n 
B 1 205 ALA 205 203 203 ALA ALA B . n 
B 1 206 TYR 206 204 204 TYR TYR B . n 
B 1 207 THR 207 205 205 THR THR B . n 
B 1 208 ARG 208 206 206 ARG ARG B . n 
B 1 209 VAL 209 207 207 VAL VAL B . n 
B 1 210 ILE 210 208 208 ILE ILE B . n 
B 1 211 GLU 211 209 209 GLU GLU B . n 
B 1 212 ARG 212 210 210 ARG ARG B . n 
B 1 213 ASP 213 211 211 ASP ASP B . n 
B 1 214 ILE 214 212 212 ILE ILE B . n 
B 1 215 GLN 215 213 213 GLN GLN B . n 
B 1 216 ARG 216 214 214 ARG ARG B . n 
B 1 217 ILE 217 215 215 ILE ILE B . n 
B 1 218 LYS 218 216 216 LYS LYS B . n 
B 1 219 GLN 219 217 217 GLN GLN B . n 
B 1 220 SER 220 218 218 SER SER B . n 
B 1 221 ARG 221 219 219 ARG ARG B . n 
B 1 222 GLY 222 220 220 GLY GLY B . n 
B 1 223 HIS 223 221 221 HIS HIS B . n 
B 1 224 LEU 224 222 222 LEU LEU B . n 
B 1 225 TYR 225 223 223 TYR TYR B . n 
B 1 226 GLU 226 224 224 GLU GLU B . n 
B 1 227 ILE 227 225 225 ILE ILE B . n 
B 1 228 ASN 228 226 226 ASN ASN B . n 
B 1 229 MET 229 227 227 MET MET B . n 
B 1 230 GLY 230 228 228 GLY GLY B . n 
B 1 231 ALA 231 229 229 ALA ALA B . n 
B 1 232 THR 232 230 230 THR THR B . n 
B 1 233 ALA 233 231 231 ALA ALA B . n 
B 1 234 VAL 234 232 232 VAL VAL B . n 
B 1 235 GLY 235 233 233 GLY GLY B . n 
B 1 236 THR 236 234 234 THR THR B . n 
B 1 237 GLY 237 235 235 GLY GLY B . n 
B 1 238 LEU 238 236 236 LEU LEU B . n 
B 1 239 ASN 239 237 237 ASN ASN B . n 
B 1 240 ALA 240 238 238 ALA ALA B . n 
B 1 241 ASP 241 239 239 ASP ASP B . n 
B 1 242 PRO 242 240 240 PRO PRO B . n 
B 1 243 ARG 243 241 241 ARG ARG B . n 
B 1 244 TYR 244 242 242 TYR TYR B . n 
B 1 245 ILE 245 243 243 ILE ILE B . n 
B 1 246 GLU 246 244 244 GLU GLU B . n 
B 1 247 SER 247 245 245 SER SER B . n 
B 1 248 VAL 248 246 246 VAL VAL B . n 
B 1 249 VAL 249 247 247 VAL VAL B . n 
B 1 250 LYS 250 248 248 LYS LYS B . n 
B 1 251 HIS 251 249 249 HIS HIS B . n 
B 1 252 LEU 252 250 250 LEU LEU B . n 
B 1 253 ARG 253 251 251 ARG ARG B . n 
B 1 254 GLU 254 252 252 GLU GLU B . n 
B 1 255 ILE 255 253 253 ILE ILE B . n 
B 1 256 SER 256 254 254 SER SER B . n 
B 1 257 GLY 257 255 255 GLY GLY B . n 
B 1 258 TYR 258 256 256 TYR TYR B . n 
B 1 259 PRO 259 257 257 PRO PRO B . n 
B 1 260 LEU 260 258 258 LEU LEU B . n 
B 1 261 VAL 261 259 259 VAL VAL B . n 
B 1 262 GLY 262 260 260 GLY GLY B . n 
B 1 263 ALA 263 261 261 ALA ALA B . n 
B 1 264 GLU 264 262 262 GLU GLU B . n 
B 1 265 ASN 265 263 263 ASN ASN B . n 
B 1 266 LEU 266 264 264 LEU LEU B . n 
B 1 267 VAL 267 265 265 VAL VAL B . n 
B 1 268 ASP 268 266 266 ASP ASP B . n 
B 1 269 ALA 269 267 267 ALA ALA B . n 
B 1 270 THR 270 268 268 THR THR B . n 
B 1 271 GLN 271 269 269 GLN GLN B . n 
B 1 272 ASN 272 270 270 ASN ASN B . n 
B 1 273 THR 273 271 271 THR THR B . n 
B 1 274 ASP 274 272 272 ASP ASP B . n 
B 1 275 ALA 275 273 273 ALA ALA B . n 
B 1 276 TYR 276 274 274 TYR TYR B . n 
B 1 277 THR 277 275 275 THR THR B . n 
B 1 278 GLU 278 276 276 GLU GLU B . n 
B 1 279 VAL 279 277 277 VAL VAL B . n 
B 1 280 SER 280 278 278 SER SER B . n 
B 1 281 ALA 281 279 279 ALA ALA B . n 
B 1 282 ALA 282 280 280 ALA ALA B . n 
B 1 283 LEU 283 281 281 LEU LEU B . n 
B 1 284 LYS 284 282 282 LYS LYS B . n 
B 1 285 VAL 285 283 283 VAL VAL B . n 
B 1 286 CYS 286 284 284 CYS CYS B . n 
B 1 287 MET 287 285 285 MET MET B . n 
B 1 288 MET 288 286 286 MET MET B . n 
B 1 289 ASN 289 287 287 ASN ASN B . n 
B 1 290 MET 290 288 288 MET MET B . n 
B 1 291 SER 291 289 289 SER SER B . n 
B 1 292 LYS 292 290 290 LYS LYS B . n 
B 1 293 ILE 293 291 291 ILE ILE B . n 
B 1 294 ALA 294 292 292 ALA ALA B . n 
B 1 295 ASN 295 293 293 ASN ASN B . n 
B 1 296 ASP 296 294 294 ASP ASP B . n 
B 1 297 LEU 297 295 295 LEU LEU B . n 
B 1 298 ARG 298 296 296 ARG ARG B . n 
B 1 299 LEU 299 297 297 LEU LEU B . n 
B 1 300 MET 300 298 298 MET MET B . n 
B 1 301 ALA 301 299 299 ALA ALA B . n 
B 1 302 SER 302 300 300 SER SER B . n 
B 1 303 GLY 303 301 301 GLY GLY B . n 
B 1 304 PRO 304 302 302 PRO PRO B . n 
B 1 305 ARG 305 303 303 ARG ARG B . n 
B 1 306 ALA 306 304 304 ALA ALA B . n 
B 1 307 GLY 307 305 305 GLY GLY B . n 
B 1 308 LEU 308 306 306 LEU LEU B . n 
B 1 309 GLY 309 307 307 GLY GLY B . n 
B 1 310 GLU 310 308 308 GLU GLU B . n 
B 1 311 ILE 311 309 309 ILE ILE B . n 
B 1 312 THR 312 310 310 THR THR B . n 
B 1 313 LEU 313 311 311 LEU LEU B . n 
B 1 314 PRO 314 312 312 PRO PRO B . n 
B 1 315 ALA 315 313 313 ALA ALA B . n 
B 1 316 ARG 316 314 314 ARG ARG B . n 
B 1 317 GLN 317 315 315 GLN GLN B . n 
B 1 318 PRO 318 316 316 PRO PRO B . n 
B 1 319 GLY 319 317 317 GLY GLY B . n 
B 1 320 SER 320 318 318 SER SER B . n 
B 1 321 SER 321 319 319 SER SER B . n 
B 1 322 ILE 322 320 320 ILE ILE B . n 
B 1 323 ILE 323 321 321 ILE ILE B . n 
B 1 324 PRO 324 322 322 PRO PRO B . n 
B 1 325 GLY 325 323 323 GLY GLY B . n 
B 1 326 MET 326 324 324 MET MET B . n 
B 1 327 VAL 327 325 325 VAL VAL B . n 
B 1 328 CYS 328 326 326 CYS CYS B . n 
B 1 329 PRO 329 327 327 PRO PRO B . n 
B 1 330 VAL 330 328 328 VAL VAL B . n 
B 1 331 MET 331 329 329 MET MET B . n 
B 1 332 ALA 332 330 330 ALA ALA B . n 
B 1 333 GLU 333 331 331 GLU GLU B . n 
B 1 334 VAL 334 332 332 VAL VAL B . n 
B 1 335 ILE 335 333 333 ILE ILE B . n 
B 1 336 ASN 336 334 334 ASN ASN B . n 
B 1 337 GLN 337 335 335 GLN GLN B . n 
B 1 338 ILE 338 336 336 ILE ILE B . n 
B 1 339 ALA 339 337 337 ALA ALA B . n 
B 1 340 PHE 340 338 338 PHE PHE B . n 
B 1 341 GLN 341 339 339 GLN GLN B . n 
B 1 342 VAL 342 340 340 VAL VAL B . n 
B 1 343 ILE 343 341 341 ILE ILE B . n 
B 1 344 GLY 344 342 342 GLY GLY B . n 
B 1 345 ASN 345 343 343 ASN ASN B . n 
B 1 346 ASP 346 344 344 ASP ASP B . n 
B 1 347 HIS 347 345 345 HIS HIS B . n 
B 1 348 THR 348 346 346 THR THR B . n 
B 1 349 ILE 349 347 347 ILE ILE B . n 
B 1 350 CYS 350 348 348 CYS CYS B . n 
B 1 351 LEU 351 349 349 LEU LEU B . n 
B 1 352 ALA 352 350 350 ALA ALA B . n 
B 1 353 SER 353 351 351 SER SER B . n 
B 1 354 GLU 354 352 352 GLU GLU B . n 
B 1 355 ALA 355 353 353 ALA ALA B . n 
B 1 356 GLY 356 354 354 GLY GLY B . n 
B 1 357 GLN 357 355 355 GLN GLN B . n 
B 1 358 LEU 358 356 356 LEU LEU B . n 
B 1 359 GLU 359 357 357 GLU GLU B . n 
B 1 360 LEU 360 358 358 LEU LEU B . n 
B 1 361 ASN 361 359 359 ASN ASN B . n 
B 1 362 VAL 362 360 360 VAL VAL B . n 
B 1 363 MET 363 361 361 MET MET B . n 
B 1 364 GLU 364 362 362 GLU GLU B . n 
B 1 365 PRO 365 363 363 PRO PRO B . n 
B 1 366 VAL 366 364 364 VAL VAL B . n 
B 1 367 LEU 367 365 365 LEU LEU B . n 
B 1 368 VAL 368 366 366 VAL VAL B . n 
B 1 369 PHE 369 367 367 PHE PHE B . n 
B 1 370 ASN 370 368 368 ASN ASN B . n 
B 1 371 LEU 371 369 369 LEU LEU B . n 
B 1 372 LEU 372 370 370 LEU LEU B . n 
B 1 373 GLN 373 371 371 GLN GLN B . n 
B 1 374 SER 374 372 372 SER SER B . n 
B 1 375 ILE 375 373 373 ILE ILE B . n 
B 1 376 SER 376 374 374 SER SER B . n 
B 1 377 ILE 377 375 375 ILE ILE B . n 
B 1 378 MET 378 376 376 MET MET B . n 
B 1 379 ASN 379 377 377 ASN ASN B . n 
B 1 380 ASN 380 378 378 ASN ASN B . n 
B 1 381 GLY 381 379 379 GLY GLY B . n 
B 1 382 PHE 382 380 380 PHE PHE B . n 
B 1 383 ARG 383 381 381 ARG ARG B . n 
B 1 384 VAL 384 382 382 VAL VAL B . n 
B 1 385 PHE 385 383 383 PHE PHE B . n 
B 1 386 THR 386 384 384 THR THR B . n 
B 1 387 GLU 387 385 385 GLU GLU B . n 
B 1 388 TYR 388 386 386 TYR TYR B . n 
B 1 389 CYS 389 387 387 CYS CYS B . n 
B 1 390 VAL 390 388 388 VAL VAL B . n 
B 1 391 LYS 391 389 389 LYS LYS B . n 
B 1 392 GLY 392 390 390 GLY GLY B . n 
B 1 393 ILE 393 391 391 ILE ILE B . n 
B 1 394 GLU 394 392 392 GLU GLU B . n 
B 1 395 ALA 395 393 393 ALA ALA B . n 
B 1 396 ASN 396 394 394 ASN ASN B . n 
B 1 397 GLU 397 395 395 GLU GLU B . n 
B 1 398 GLU 398 396 396 GLU GLU B . n 
B 1 399 LYS 399 397 397 LYS LYS B . n 
B 1 400 MET 400 398 398 MET MET B . n 
B 1 401 LYS 401 399 399 LYS LYS B . n 
B 1 402 GLU 402 400 400 GLU GLU B . n 
B 1 403 TYR 403 401 401 TYR TYR B . n 
B 1 404 VAL 404 402 402 VAL VAL B . n 
B 1 405 GLU 405 403 403 GLU GLU B . n 
B 1 406 LYS 406 404 404 LYS LYS B . n 
B 1 407 SER 407 405 405 SER SER B . n 
B 1 408 VAL 408 406 406 VAL VAL B . n 
B 1 409 GLY 409 407 407 GLY GLY B . n 
B 1 410 VAL 410 408 408 VAL VAL B . n 
B 1 411 ILE 411 409 409 ILE ILE B . n 
B 1 412 THR 412 410 410 THR THR B . n 
B 1 413 ALA 413 411 411 ALA ALA B . n 
B 1 414 VAL 414 412 412 VAL VAL B . n 
B 1 415 ASN 415 413 413 ASN ASN B . n 
B 1 416 PRO 416 414 414 PRO PRO B . n 
B 1 417 HIS 417 415 415 HIS HIS B . n 
B 1 418 ILE 418 416 416 ILE ILE B . n 
B 1 419 GLY 419 417 417 GLY GLY B . n 
B 1 420 TYR 420 418 418 TYR TYR B . n 
B 1 421 GLU 421 419 419 GLU GLU B . n 
B 1 422 VAL 422 420 420 VAL VAL B . n 
B 1 423 ALA 423 421 421 ALA ALA B . n 
B 1 424 SER 424 422 422 SER SER B . n 
B 1 425 ARG 425 423 423 ARG ARG B . n 
B 1 426 ILE 426 424 424 ILE ILE B . n 
B 1 427 ALA 427 425 425 ALA ALA B . n 
B 1 428 ARG 428 426 426 ARG ARG B . n 
B 1 429 GLU 429 427 427 GLU GLU B . n 
B 1 430 ALA 430 428 428 ALA ALA B . n 
B 1 431 THR 431 429 429 THR THR B . n 
B 1 432 LEU 432 430 430 LEU LEU B . n 
B 1 433 THR 433 431 431 THR THR B . n 
B 1 434 GLY 434 432 432 GLY GLY B . n 
B 1 435 GLN 435 433 433 GLN GLN B . n 
B 1 436 SER 436 434 434 SER SER B . n 
B 1 437 VAL 437 435 435 VAL VAL B . n 
B 1 438 ARG 438 436 436 ARG ARG B . n 
B 1 439 ASP 439 437 437 ASP ASP B . n 
B 1 440 LEU 440 438 438 LEU LEU B . n 
B 1 441 CYS 441 439 439 CYS CYS B . n 
B 1 442 ARG 442 440 440 ARG ARG B . n 
B 1 443 LYS 443 441 441 LYS LYS B . n 
B 1 444 TYR 444 442 442 TYR TYR B . n 
B 1 445 ASP 445 443 443 ASP ASP B . n 
B 1 446 VAL 446 444 444 VAL VAL B . n 
B 1 447 LEU 447 445 445 LEU LEU B . n 
B 1 448 SER 448 446 446 SER SER B . n 
B 1 449 ASP 449 447 447 ASP ASP B . n 
B 1 450 GLU 450 448 448 GLU GLU B . n 
B 1 451 GLU 451 449 449 GLU GLU B . n 
B 1 452 LEU 452 450 450 LEU LEU B . n 
B 1 453 ASP 453 451 451 ASP ASP B . n 
B 1 454 LEU 454 452 452 LEU LEU B . n 
B 1 455 ILE 455 453 453 ILE ILE B . n 
B 1 456 LEU 456 454 454 LEU LEU B . n 
B 1 457 ASP 457 455 455 ASP ASP B . n 
B 1 458 PRO 458 456 456 PRO PRO B . n 
B 1 459 TYR 459 457 457 TYR TYR B . n 
B 1 460 GLU 460 458 458 GLU GLU B . n 
B 1 461 MET 461 459 459 MET MET B . n 
B 1 462 THR 462 460 460 THR THR B . n 
B 1 463 HIS 463 461 461 HIS HIS B . n 
B 1 464 PRO 464 462 ?   ?   ?   B . n 
B 1 465 GLY 465 463 ?   ?   ?   B . n 
B 1 466 ILE 466 464 ?   ?   ?   B . n 
B 1 467 ALA 467 465 ?   ?   ?   B . n 
B 1 468 GLY 468 466 ?   ?   ?   B . n 
B 1 469 ALA 469 467 ?   ?   ?   B . n 
B 1 470 SER 470 468 ?   ?   ?   B . n 
B 1 471 LEU 471 469 ?   ?   ?   B . n 
B 1 472 LEU 472 470 ?   ?   ?   B . n 
B 1 473 GLU 473 471 ?   ?   ?   B . n 
B 1 474 ARG 474 472 ?   ?   ?   B . n 
B 1 475 ASP 475 473 ?   ?   ?   B . n 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC  ? ? ? 5.8.0419 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .        2 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .        3 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .        4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8RJ1 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     164.182 
_cell.length_a_esd                 ? 
_cell.length_b                     164.182 
_cell.length_b_esd                 ? 
_cell.length_c                     86.819 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        12 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8RJ1 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                154 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 32 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8RJ1 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             3.25 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          62.19 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.2 M MgCl2, 0.1 M Tris pH 8.5, and 20% (w/v) PEG 8000' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            298 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS3 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-07-26 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.9654 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'ESRF BEAMLINE MASSIF-1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.9654 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   MASSIF-1 
_diffrn_source.pdbx_synchrotron_site       ESRF 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8RJ1 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              3.10 
_reflns.d_resolution_low                               47.44 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     24734 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.9 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                14.7 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          8.9 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               1.01 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.377 
_reflns.pdbx_Rpim_I_all                                0.097 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.995 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.364 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    3.10 
_reflns_shell.d_res_low                                     3.31 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           63226 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             4419 
_reflns_shell.percent_possible_obs                          100.0 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               14.3 
_reflns_shell.pdbx_chi_squared                              0.95 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     1.4 
_reflns_shell.pdbx_Rrim_I_all                               2.428 
_reflns_shell.pdbx_Rpim_I_all                               0.637 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.578 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  2.342 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            2.18 
_refine.aniso_B[1][2]                            1.09 
_refine.aniso_B[1][3]                            0.00 
_refine.aniso_B[2][2]                            2.18 
_refine.aniso_B[2][3]                            -0.00 
_refine.aniso_B[3][3]                            -7.07 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               84.845 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.940 
_refine.correlation_coeff_Fo_to_Fc_free          0.909 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8RJ1 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            3.10 
_refine.ls_d_res_low                             47.44 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     23470 
_refine.ls_number_reflns_R_free                  1241 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.92 
_refine.ls_percent_reflns_R_free                 5.0 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.20685 
_refine.ls_R_factor_R_free                       0.25891 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.20410 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  0.449 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             25.202 
_refine.overall_SU_ML                            0.409 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       3.10 
_refine_hist.d_res_low                        47.44 
_refine_hist.number_atoms_solvent             0 
_refine_hist.number_atoms_total               7125 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        7125 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.005  0.012  7212  ? r_bond_refined_d             ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.016  6995  ? r_bond_other_d               ? ? 
'X-RAY DIFFRACTION' ? 1.505  1.824  9764  ? r_angle_refined_deg          ? ? 
'X-RAY DIFFRACTION' ? 0.516  1.755  16079 ? r_angle_other_deg            ? ? 
'X-RAY DIFFRACTION' ? 6.622  5.000  917   ? r_dihedral_angle_1_deg       ? ? 
'X-RAY DIFFRACTION' ? 7.407  5.000  50    ? r_dihedral_angle_2_deg       ? ? 
'X-RAY DIFFRACTION' ? 15.512 10.000 1272  ? r_dihedral_angle_3_deg       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_dihedral_angle_4_deg       ? ? 
'X-RAY DIFFRACTION' ? 0.072  0.200  1122  ? r_chiral_restr               ? ? 
'X-RAY DIFFRACTION' ? 0.005  0.020  8522  ? r_gen_planes_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.020  1582  ? r_gen_planes_other           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbd_refined                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbd_other                  ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbtor_refined              ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_nbtor_other                ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_xyhbond_nbd_refined        ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_xyhbond_nbd_other          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_metal_ion_refined          ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_metal_ion_other            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_vdw_refined       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_vdw_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_hbond_refined     ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_hbond_other       ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_metal_ion_refined ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_symmetry_metal_ion_other   ? ? 
'X-RAY DIFFRACTION' ? 7.023  8.275  3674  ? r_mcbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 7.023  8.275  3674  ? r_mcbond_other               ? ? 
'X-RAY DIFFRACTION' ? 10.689 14.876 4589  ? r_mcangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 10.689 14.876 4590  ? r_mcangle_other              ? ? 
'X-RAY DIFFRACTION' ? 7.471  8.807  3538  ? r_scbond_it                  ? ? 
'X-RAY DIFFRACTION' ? 7.470  8.808  3539  ? r_scbond_other               ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_scangle_it                 ? ? 
'X-RAY DIFFRACTION' ? 11.847 16.013 5176  ? r_scangle_other              ? ? 
'X-RAY DIFFRACTION' ? 15.800 102.28 30612 ? r_long_range_B_refined       ? ? 
'X-RAY DIFFRACTION' ? 15.800 102.28 30613 ? r_long_range_B_other         ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_rigid_bond_restr           ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_sphericity_free            ? ? 
'X-RAY DIFFRACTION' ? ?      ?      ?     ? r_sphericity_bonded          ? ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.d_res_high                       3.100 
_refine_ls_shell.d_res_low                        3.180 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.number_reflns_obs                ? 
_refine_ls_shell.number_reflns_R_free             79 
_refine_ls_shell.number_reflns_R_work             1689 
_refine_ls_shell.percent_reflns_obs               100.00 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.R_factor_R_work                  0.352 
_refine_ls_shell.redundancy_reflns_all            ? 
_refine_ls_shell.redundancy_reflns_obs            ? 
_refine_ls_shell.wR_factor_all                    ? 
_refine_ls_shell.wR_factor_obs                    ? 
_refine_ls_shell.wR_factor_R_free                 ? 
_refine_ls_shell.wR_factor_R_work                 ? 
_refine_ls_shell.pdbx_R_complete                  ? 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.pdbx_phase_error                 ? 
_refine_ls_shell.pdbx_fsc_work                    ? 
_refine_ls_shell.pdbx_fsc_free                    ? 
_refine_ls_shell.R_factor_R_free                  0.368 
# 
_struct.entry_id                     8RJ1 
_struct.title                        
'Crystal structure of mutant aspartase from Caenibacillus caldisaponilyticus in the closed loop conformation' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8RJ1 
_struct_keywords.text            'ammonia aspartate lyase, closed conformation, LYASE, Caenibacillus caldisaponilyticus' 
_struct_keywords.pdbx_keywords   LYASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    PDB 
_struct_ref.db_code                    8RJ1 
_struct_ref.pdbx_db_accession          8RJ1 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   ? 
_struct_ref.pdbx_align_begin           1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8RJ1 A 1 ? 475 ? 8RJ1 -1 ? 473 ? -1 473 
2 1 8RJ1 B 1 ? 475 ? 8RJ1 -1 ? 473 ? -1 473 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   tetrameric 
_pdbx_struct_assembly.oligomeric_count     4 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 31010 ? 
1 MORE         -153  ? 
1 'SSA (A^2)'  54730 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z          1.0000000000  0.0000000000  0.0000000000 0.0000000000 0.0000000000  
1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000   
2 'crystal symmetry operation' 6_554 -x,-x+y,-z-1/3 -0.5000000000 -0.8660254038 0.0000000000 0.0000000000 -0.8660254038 
0.5000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 -28.9396666667 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLY A 26  ? PHE A 36  ? GLY A 24  PHE A 34  1 ? 11 
HELX_P HELX_P2  AA2 HIS A 44  ? THR A 65  ? HIS A 42  THR A 63  1 ? 22 
HELX_P HELX_P3  AA3 PRO A 69  ? GLY A 86  ? PRO A 67  GLY A 84  1 ? 18 
HELX_P HELX_P4  AA4 GLN A 87  ? PHE A 92  ? GLN A 85  PHE A 90  5 ? 6  
HELX_P HELX_P5  AA5 GLY A 99  ? ALA A 101 ? GLY A 97  ALA A 99  5 ? 3  
HELX_P HELX_P6  AA6 GLY A 102 ? MET A 121 ? GLY A 100 MET A 119 1 ? 20 
HELX_P HELX_P7  AA7 SER A 142 ? PHE A 180 ? SER A 140 PHE A 178 1 ? 39 
HELX_P HELX_P8  AA8 LEU A 199 ? ARG A 221 ? LEU A 197 ARG A 219 1 ? 23 
HELX_P HELX_P9  AA9 GLY A 222 ? LEU A 224 ? GLY A 220 LEU A 222 5 ? 3  
HELX_P HELX_P10 AB1 ASP A 241 ? GLY A 257 ? ASP A 239 GLY A 255 1 ? 17 
HELX_P HELX_P11 AB2 ASN A 265 ? ASN A 272 ? ASN A 263 ASN A 270 1 ? 8  
HELX_P HELX_P12 AB3 THR A 273 ? ALA A 301 ? THR A 271 ALA A 299 1 ? 29 
HELX_P HELX_P13 AB4 PRO A 329 ? ALA A 355 ? PRO A 327 ALA A 353 1 ? 27 
HELX_P HELX_P14 AB5 MET A 363 ? CYS A 389 ? MET A 361 CYS A 387 1 ? 27 
HELX_P HELX_P15 AB6 VAL A 390 ? ILE A 393 ? VAL A 388 ILE A 391 5 ? 4  
HELX_P HELX_P16 AB7 ASN A 396 ? LYS A 406 ? ASN A 394 LYS A 404 1 ? 11 
HELX_P HELX_P17 AB8 SER A 407 ? ALA A 413 ? SER A 405 ALA A 411 5 ? 7  
HELX_P HELX_P18 AB9 VAL A 414 ? GLY A 419 ? VAL A 412 GLY A 417 1 ? 6  
HELX_P HELX_P19 AC1 GLY A 419 ? GLY A 434 ? GLY A 417 GLY A 432 1 ? 16 
HELX_P HELX_P20 AC2 SER A 436 ? TYR A 444 ? SER A 434 TYR A 442 1 ? 9  
HELX_P HELX_P21 AC3 SER A 448 ? LEU A 456 ? SER A 446 LEU A 454 1 ? 9  
HELX_P HELX_P22 AC4 TYR A 459 ? HIS A 463 ? TYR A 457 HIS A 461 5 ? 5  
HELX_P HELX_P23 AC5 GLY B 26  ? PHE B 36  ? GLY B 24  PHE B 34  1 ? 11 
HELX_P HELX_P24 AC6 HIS B 44  ? THR B 65  ? HIS B 42  THR B 63  1 ? 22 
HELX_P HELX_P25 AC7 PRO B 69  ? GLY B 86  ? PRO B 67  GLY B 84  1 ? 18 
HELX_P HELX_P26 AC8 TRP B 88  ? PHE B 92  ? TRP B 86  PHE B 90  5 ? 5  
HELX_P HELX_P27 AC9 GLY B 99  ? ALA B 101 ? GLY B 97  ALA B 99  5 ? 3  
HELX_P HELX_P28 AD1 GLY B 102 ? MET B 121 ? GLY B 100 MET B 119 1 ? 20 
HELX_P HELX_P29 AD2 SER B 142 ? PHE B 180 ? SER B 140 PHE B 178 1 ? 39 
HELX_P HELX_P30 AD3 LEU B 199 ? ARG B 221 ? LEU B 197 ARG B 219 1 ? 23 
HELX_P HELX_P31 AD4 GLY B 222 ? LEU B 224 ? GLY B 220 LEU B 222 5 ? 3  
HELX_P HELX_P32 AD5 ASP B 241 ? GLY B 257 ? ASP B 239 GLY B 255 1 ? 17 
HELX_P HELX_P33 AD6 ASN B 265 ? ASN B 272 ? ASN B 263 ASN B 270 1 ? 8  
HELX_P HELX_P34 AD7 THR B 273 ? ALA B 301 ? THR B 271 ALA B 299 1 ? 29 
HELX_P HELX_P35 AD8 PRO B 329 ? ALA B 355 ? PRO B 327 ALA B 353 1 ? 27 
HELX_P HELX_P36 AD9 MET B 363 ? CYS B 389 ? MET B 361 CYS B 387 1 ? 27 
HELX_P HELX_P37 AE1 VAL B 390 ? ILE B 393 ? VAL B 388 ILE B 391 5 ? 4  
HELX_P HELX_P38 AE2 ASN B 396 ? LYS B 406 ? ASN B 394 LYS B 404 1 ? 11 
HELX_P HELX_P39 AE3 SER B 407 ? ALA B 413 ? SER B 405 ALA B 411 5 ? 7  
HELX_P HELX_P40 AE4 VAL B 414 ? GLY B 419 ? VAL B 412 GLY B 417 1 ? 6  
HELX_P HELX_P41 AE5 GLY B 419 ? GLY B 434 ? GLY B 417 GLY B 432 1 ? 16 
HELX_P HELX_P42 AE6 SER B 436 ? TYR B 444 ? SER B 434 TYR B 442 1 ? 9  
HELX_P HELX_P43 AE7 SER B 448 ? LEU B 456 ? SER B 446 LEU B 454 1 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 GLY 303 A . ? GLY 301 A PRO 304 A ? PRO 302 A 1 19.28 
2 GLY 303 B . ? GLY 301 B PRO 304 B ? PRO 302 B 1 14.65 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 2 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
AA5 ? 2 ? 
AA6 ? 2 ? 
AA7 ? 2 ? 
AA8 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? parallel      
AA4 1 2 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA7 1 2 ? parallel      
AA8 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ARG A 8   ? ASP A 12  ? ARG A 6   ASP A 10  
AA1 2 GLY A 15  ? ILE A 19  ? GLY A 13  ILE A 17  
AA2 1 ILE A 184 ? ILE A 189 ? ILE A 182 ILE A 187 
AA2 2 GLN A 192 ? ARG A 198 ? GLN A 190 ARG A 196 
AA3 1 GLU A 226 ? ILE A 227 ? GLU A 224 ILE A 225 
AA3 2 VAL A 261 ? GLY A 262 ? VAL A 259 GLY A 260 
AA4 1 ILE A 311 ? THR A 312 ? ILE A 309 THR A 310 
AA4 2 GLU A 394 ? ALA A 395 ? GLU A 392 ALA A 393 
AA5 1 ARG B 8   ? LYS B 11  ? ARG B 6   LYS B 9   
AA5 2 GLU B 16  ? ILE B 19  ? GLU B 14  ILE B 17  
AA6 1 ILE B 184 ? ILE B 189 ? ILE B 182 ILE B 187 
AA6 2 GLN B 192 ? ARG B 198 ? GLN B 190 ARG B 196 
AA7 1 GLU B 226 ? ILE B 227 ? GLU B 224 ILE B 225 
AA7 2 VAL B 261 ? GLY B 262 ? VAL B 259 GLY B 260 
AA8 1 ILE B 311 ? THR B 312 ? ILE B 309 THR B 310 
AA8 2 GLU B 394 ? ALA B 395 ? GLU B 392 ALA B 393 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ARG A 8   ? N ARG A 6   O ILE A 19  ? O ILE A 17  
AA2 1 2 N ILE A 189 ? N ILE A 187 O GLN A 192 ? O GLN A 190 
AA3 1 2 N ILE A 227 ? N ILE A 225 O VAL A 261 ? O VAL A 259 
AA4 1 2 N THR A 312 ? N THR A 310 O GLU A 394 ? O GLU A 392 
AA5 1 2 N ARG B 8   ? N ARG B 6   O ILE B 19  ? O ILE B 17  
AA6 1 2 N ILE B 189 ? N ILE B 187 O GLN B 192 ? O GLN B 190 
AA7 1 2 N ILE B 227 ? N ILE B 225 O VAL B 261 ? O VAL B 259 
AA8 1 2 N THR B 312 ? N THR B 310 O GLU B 394 ? O GLU B 392 
# 
_pdbx_entry_details.entry_id                   8RJ1 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_symm_contact.id 
_pdbx_validate_symm_contact.PDB_model_num 
_pdbx_validate_symm_contact.auth_atom_id_1 
_pdbx_validate_symm_contact.auth_asym_id_1 
_pdbx_validate_symm_contact.auth_comp_id_1 
_pdbx_validate_symm_contact.auth_seq_id_1 
_pdbx_validate_symm_contact.PDB_ins_code_1 
_pdbx_validate_symm_contact.label_alt_id_1 
_pdbx_validate_symm_contact.site_symmetry_1 
_pdbx_validate_symm_contact.auth_atom_id_2 
_pdbx_validate_symm_contact.auth_asym_id_2 
_pdbx_validate_symm_contact.auth_comp_id_2 
_pdbx_validate_symm_contact.auth_seq_id_2 
_pdbx_validate_symm_contact.PDB_ins_code_2 
_pdbx_validate_symm_contact.label_alt_id_2 
_pdbx_validate_symm_contact.site_symmetry_2 
_pdbx_validate_symm_contact.dist 
1 1 OE1 A GLN 217 ? ? 1_555 OE1 A GLN 217 ? ? 6_554 1.77 
2 1 OE1 B GLN 217 ? ? 1_555 OE1 B GLN 217 ? ? 6_554 1.89 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ILE A 36  ? ? -98.64  -66.38  
2  1 GLN A 85  ? ? -81.03  -70.99  
3  1 TRP A 86  ? ? -93.76  32.59   
4  1 LEU A 189 ? ? 75.56   -1.40   
5  1 ALA A 192 ? ? -123.02 -119.28 
6  1 THR A 230 ? ? 60.83   -132.16 
7  1 ASN A 237 ? ? 81.78   10.00   
8  1 LEU A 356 ? ? 55.26   -119.87 
9  1 CYS A 387 ? ? -139.45 -66.94  
10 1 ASN A 394 ? ? -106.33 64.80   
11 1 LEU A 454 ? ? -94.62  35.16   
12 1 ILE B 36  ? ? -98.74  -67.63  
13 1 GLN B 85  ? ? -79.52  -71.85  
14 1 TRP B 86  ? ? -94.06  32.70   
15 1 LEU B 189 ? ? 74.82   -0.65   
16 1 ALA B 192 ? ? -117.22 -93.78  
17 1 THR B 230 ? ? 60.27   -130.06 
18 1 ASN B 237 ? ? 81.54   8.07    
19 1 ARG B 303 ? ? -121.27 -56.85  
20 1 LEU B 356 ? ? 55.47   -120.88 
21 1 ASN B 394 ? ? -108.54 64.40   
22 1 LEU B 454 ? ? -94.06  35.23   
# 
loop_
_pdbx_validate_planes.id 
_pdbx_validate_planes.PDB_model_num 
_pdbx_validate_planes.auth_comp_id 
_pdbx_validate_planes.auth_asym_id 
_pdbx_validate_planes.auth_seq_id 
_pdbx_validate_planes.PDB_ins_code 
_pdbx_validate_planes.label_alt_id 
_pdbx_validate_planes.rmsd 
_pdbx_validate_planes.type 
1 1 ARG B 6   ? ? 0.100 'SIDE CHAIN' 
2 1 ARG B 296 ? ? 0.083 'SIDE CHAIN' 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET -1  ? A MET 1   
2  1 Y 1 A GLN 0   ? A GLN 2   
3  1 Y 1 A GLN 1   ? A GLN 3   
4  1 Y 1 A GLU 2   ? A GLU 4   
5  1 Y 1 A GLN 3   ? A GLN 5   
6  1 Y 1 A SER 4   ? A SER 6   
7  1 Y 1 A ALA 467 ? A ALA 469 
8  1 Y 1 A SER 468 ? A SER 470 
9  1 Y 1 A LEU 469 ? A LEU 471 
10 1 Y 1 A LEU 470 ? A LEU 472 
11 1 Y 1 A GLU 471 ? A GLU 473 
12 1 Y 1 A ARG 472 ? A ARG 474 
13 1 Y 1 A ASP 473 ? A ASP 475 
14 1 Y 1 B MET -1  ? B MET 1   
15 1 Y 1 B GLN 0   ? B GLN 2   
16 1 Y 1 B GLN 1   ? B GLN 3   
17 1 Y 1 B GLU 2   ? B GLU 4   
18 1 Y 1 B GLN 3   ? B GLN 5   
19 1 Y 1 B SER 4   ? B SER 6   
20 1 Y 1 B PRO 462 ? B PRO 464 
21 1 Y 1 B GLY 463 ? B GLY 465 
22 1 Y 1 B ILE 464 ? B ILE 466 
23 1 Y 1 B ALA 465 ? B ALA 467 
24 1 Y 1 B GLY 466 ? B GLY 468 
25 1 Y 1 B ALA 467 ? B ALA 469 
26 1 Y 1 B SER 468 ? B SER 470 
27 1 Y 1 B LEU 469 ? B LEU 471 
28 1 Y 1 B LEU 470 ? B LEU 472 
29 1 Y 1 B GLU 471 ? B GLU 473 
30 1 Y 1 B ARG 472 ? B ARG 474 
31 1 Y 1 B ASP 473 ? B ASP 475 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
PHE N    N N N 247 
PHE CA   C N S 248 
PHE C    C N N 249 
PHE O    O N N 250 
PHE CB   C N N 251 
PHE CG   C Y N 252 
PHE CD1  C Y N 253 
PHE CD2  C Y N 254 
PHE CE1  C Y N 255 
PHE CE2  C Y N 256 
PHE CZ   C Y N 257 
PHE OXT  O N N 258 
PHE H    H N N 259 
PHE H2   H N N 260 
PHE HA   H N N 261 
PHE HB2  H N N 262 
PHE HB3  H N N 263 
PHE HD1  H N N 264 
PHE HD2  H N N 265 
PHE HE1  H N N 266 
PHE HE2  H N N 267 
PHE HZ   H N N 268 
PHE HXT  H N N 269 
PRO N    N N N 270 
PRO CA   C N S 271 
PRO C    C N N 272 
PRO O    O N N 273 
PRO CB   C N N 274 
PRO CG   C N N 275 
PRO CD   C N N 276 
PRO OXT  O N N 277 
PRO H    H N N 278 
PRO HA   H N N 279 
PRO HB2  H N N 280 
PRO HB3  H N N 281 
PRO HG2  H N N 282 
PRO HG3  H N N 283 
PRO HD2  H N N 284 
PRO HD3  H N N 285 
PRO HXT  H N N 286 
SER N    N N N 287 
SER CA   C N S 288 
SER C    C N N 289 
SER O    O N N 290 
SER CB   C N N 291 
SER OG   O N N 292 
SER OXT  O N N 293 
SER H    H N N 294 
SER H2   H N N 295 
SER HA   H N N 296 
SER HB2  H N N 297 
SER HB3  H N N 298 
SER HG   H N N 299 
SER HXT  H N N 300 
THR N    N N N 301 
THR CA   C N S 302 
THR C    C N N 303 
THR O    O N N 304 
THR CB   C N R 305 
THR OG1  O N N 306 
THR CG2  C N N 307 
THR OXT  O N N 308 
THR H    H N N 309 
THR H2   H N N 310 
THR HA   H N N 311 
THR HB   H N N 312 
THR HG1  H N N 313 
THR HG21 H N N 314 
THR HG22 H N N 315 
THR HG23 H N N 316 
THR HXT  H N N 317 
TRP N    N N N 318 
TRP CA   C N S 319 
TRP C    C N N 320 
TRP O    O N N 321 
TRP CB   C N N 322 
TRP CG   C Y N 323 
TRP CD1  C Y N 324 
TRP CD2  C Y N 325 
TRP NE1  N Y N 326 
TRP CE2  C Y N 327 
TRP CE3  C Y N 328 
TRP CZ2  C Y N 329 
TRP CZ3  C Y N 330 
TRP CH2  C Y N 331 
TRP OXT  O N N 332 
TRP H    H N N 333 
TRP H2   H N N 334 
TRP HA   H N N 335 
TRP HB2  H N N 336 
TRP HB3  H N N 337 
TRP HD1  H N N 338 
TRP HE1  H N N 339 
TRP HE3  H N N 340 
TRP HZ2  H N N 341 
TRP HZ3  H N N 342 
TRP HH2  H N N 343 
TRP HXT  H N N 344 
TYR N    N N N 345 
TYR CA   C N S 346 
TYR C    C N N 347 
TYR O    O N N 348 
TYR CB   C N N 349 
TYR CG   C Y N 350 
TYR CD1  C Y N 351 
TYR CD2  C Y N 352 
TYR CE1  C Y N 353 
TYR CE2  C Y N 354 
TYR CZ   C Y N 355 
TYR OH   O N N 356 
TYR OXT  O N N 357 
TYR H    H N N 358 
TYR H2   H N N 359 
TYR HA   H N N 360 
TYR HB2  H N N 361 
TYR HB3  H N N 362 
TYR HD1  H N N 363 
TYR HD2  H N N 364 
TYR HE1  H N N 365 
TYR HE2  H N N 366 
TYR HH   H N N 367 
TYR HXT  H N N 368 
VAL N    N N N 369 
VAL CA   C N S 370 
VAL C    C N N 371 
VAL O    O N N 372 
VAL CB   C N N 373 
VAL CG1  C N N 374 
VAL CG2  C N N 375 
VAL OXT  O N N 376 
VAL H    H N N 377 
VAL H2   H N N 378 
VAL HA   H N N 379 
VAL HB   H N N 380 
VAL HG11 H N N 381 
VAL HG12 H N N 382 
VAL HG13 H N N 383 
VAL HG21 H N N 384 
VAL HG22 H N N 385 
VAL HG23 H N N 386 
VAL HXT  H N N 387 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
THR N   CA   sing N N 288 
THR N   H    sing N N 289 
THR N   H2   sing N N 290 
THR CA  C    sing N N 291 
THR CA  CB   sing N N 292 
THR CA  HA   sing N N 293 
THR C   O    doub N N 294 
THR C   OXT  sing N N 295 
THR CB  OG1  sing N N 296 
THR CB  CG2  sing N N 297 
THR CB  HB   sing N N 298 
THR OG1 HG1  sing N N 299 
THR CG2 HG21 sing N N 300 
THR CG2 HG22 sing N N 301 
THR CG2 HG23 sing N N 302 
THR OXT HXT  sing N N 303 
TRP N   CA   sing N N 304 
TRP N   H    sing N N 305 
TRP N   H2   sing N N 306 
TRP CA  C    sing N N 307 
TRP CA  CB   sing N N 308 
TRP CA  HA   sing N N 309 
TRP C   O    doub N N 310 
TRP C   OXT  sing N N 311 
TRP CB  CG   sing N N 312 
TRP CB  HB2  sing N N 313 
TRP CB  HB3  sing N N 314 
TRP CG  CD1  doub Y N 315 
TRP CG  CD2  sing Y N 316 
TRP CD1 NE1  sing Y N 317 
TRP CD1 HD1  sing N N 318 
TRP CD2 CE2  doub Y N 319 
TRP CD2 CE3  sing Y N 320 
TRP NE1 CE2  sing Y N 321 
TRP NE1 HE1  sing N N 322 
TRP CE2 CZ2  sing Y N 323 
TRP CE3 CZ3  doub Y N 324 
TRP CE3 HE3  sing N N 325 
TRP CZ2 CH2  doub Y N 326 
TRP CZ2 HZ2  sing N N 327 
TRP CZ3 CH2  sing Y N 328 
TRP CZ3 HZ3  sing N N 329 
TRP CH2 HH2  sing N N 330 
TRP OXT HXT  sing N N 331 
TYR N   CA   sing N N 332 
TYR N   H    sing N N 333 
TYR N   H2   sing N N 334 
TYR CA  C    sing N N 335 
TYR CA  CB   sing N N 336 
TYR CA  HA   sing N N 337 
TYR C   O    doub N N 338 
TYR C   OXT  sing N N 339 
TYR CB  CG   sing N N 340 
TYR CB  HB2  sing N N 341 
TYR CB  HB3  sing N N 342 
TYR CG  CD1  doub Y N 343 
TYR CG  CD2  sing Y N 344 
TYR CD1 CE1  sing Y N 345 
TYR CD1 HD1  sing N N 346 
TYR CD2 CE2  doub Y N 347 
TYR CD2 HD2  sing N N 348 
TYR CE1 CZ   doub Y N 349 
TYR CE1 HE1  sing N N 350 
TYR CE2 CZ   sing Y N 351 
TYR CE2 HE2  sing N N 352 
TYR CZ  OH   sing N N 353 
TYR OH  HH   sing N N 354 
TYR OXT HXT  sing N N 355 
VAL N   CA   sing N N 356 
VAL N   H    sing N N 357 
VAL N   H2   sing N N 358 
VAL CA  C    sing N N 359 
VAL CA  CB   sing N N 360 
VAL CA  HA   sing N N 361 
VAL C   O    doub N N 362 
VAL C   OXT  sing N N 363 
VAL CB  CG1  sing N N 364 
VAL CB  CG2  sing N N 365 
VAL CB  HB   sing N N 366 
VAL CG1 HG11 sing N N 367 
VAL CG1 HG12 sing N N 368 
VAL CG1 HG13 sing N N 369 
VAL CG2 HG21 sing N N 370 
VAL CG2 HG22 sing N N 371 
VAL CG2 HG23 sing N N 372 
VAL OXT HXT  sing N N 373 
# 
_pdbx_audit_support.funding_organization   'Other private' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   3R6V 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8RJ1 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.006091 
_atom_sites.fract_transf_matrix[1][2]   0.003517 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   -0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.007033 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   -0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.011518 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM 1    N N   . TYR A 1 7   ? 41.562 -89.080  32.927  1.00 85.08  ? 5   TYR A N   1 
ATOM 2    C CA  . TYR A 1 7   ? 41.071 -89.566  31.608  1.00 103.90 ? 5   TYR A CA  1 
ATOM 3    C C   . TYR A 1 7   ? 39.555 -89.722  31.666  1.00 96.75  ? 5   TYR A C   1 
ATOM 4    O O   . TYR A 1 7   ? 39.066 -90.762  32.157  1.00 88.38  ? 5   TYR A O   1 
ATOM 5    C CB  . TYR A 1 7   ? 41.747 -90.889  31.240  1.00 30.00  ? 5   TYR A CB  1 
ATOM 6    C CG  . TYR A 1 7   ? 42.641 -90.815  30.011  1.00 30.00  ? 5   TYR A CG  1 
ATOM 7    C CD1 . TYR A 1 7   ? 43.922 -90.283  30.087  1.00 30.00  ? 5   TYR A CD1 1 
ATOM 8    C CD2 . TYR A 1 7   ? 42.204 -91.280  28.779  1.00 30.00  ? 5   TYR A CD2 1 
ATOM 9    C CE1 . TYR A 1 7   ? 44.741 -90.219  28.972  1.00 30.00  ? 5   TYR A CE1 1 
ATOM 10   C CE2 . TYR A 1 7   ? 43.014 -91.224  27.658  1.00 30.00  ? 5   TYR A CE2 1 
ATOM 11   C CZ  . TYR A 1 7   ? 44.286 -90.693  27.755  1.00 30.00  ? 5   TYR A CZ  1 
ATOM 12   O OH  . TYR A 1 7   ? 45.088 -90.630  26.653  1.00 30.00  ? 5   TYR A OH  1 
ATOM 13   N N   . ARG A 1 8   ? 38.827 -88.722  31.165  1.00 89.99  ? 6   ARG A N   1 
ATOM 14   C CA  . ARG A 1 8   ? 37.366 -88.761  31.197  1.00 91.64  ? 6   ARG A CA  1 
ATOM 15   C C   . ARG A 1 8   ? 36.837 -89.781  30.183  1.00 95.31  ? 6   ARG A C   1 
ATOM 16   O O   . ARG A 1 8   ? 37.486 -90.013  29.165  1.00 129.76 ? 6   ARG A O   1 
ATOM 17   C CB  . ARG A 1 8   ? 36.737 -87.382  30.924  1.00 91.77  ? 6   ARG A CB  1 
ATOM 18   C CG  . ARG A 1 8   ? 36.799 -86.807  29.512  1.00 94.50  ? 6   ARG A CG  1 
ATOM 19   C CD  . ARG A 1 8   ? 35.714 -85.756  29.317  1.00 89.60  ? 6   ARG A CD  1 
ATOM 20   N NE  . ARG A 1 8   ? 35.806 -85.058  28.030  1.00 99.69  ? 6   ARG A NE  1 
ATOM 21   C CZ  . ARG A 1 8   ? 36.761 -84.201  27.672  1.00 106.27 ? 6   ARG A CZ  1 
ATOM 22   N NH1 . ARG A 1 8   ? 36.857 -83.792  26.417  1.00 114.77 ? 6   ARG A NH1 1 
ATOM 23   N NH2 . ARG A 1 8   ? 37.654 -83.787  28.557  1.00 106.40 ? 6   ARG A NH2 1 
ATOM 24   N N   . ILE A 1 9   ? 35.627 -90.316  30.409  1.00 79.51  ? 7   ILE A N   1 
ATOM 25   C CA  . ILE A 1 9   ? 35.019 -91.289  29.507  1.00 78.80  ? 7   ILE A CA  1 
ATOM 26   C C   . ILE A 1 9   ? 33.803 -90.670  28.822  1.00 75.71  ? 7   ILE A C   1 
ATOM 27   O O   . ILE A 1 9   ? 33.014 -90.011  29.492  1.00 65.39  ? 7   ILE A O   1 
ATOM 28   C CB  . ILE A 1 9   ? 34.656 -92.593  30.246  1.00 94.37  ? 7   ILE A CB  1 
ATOM 29   C CG1 . ILE A 1 9   ? 35.938 -93.341  30.682  1.00 107.43 ? 7   ILE A CG1 1 
ATOM 30   C CG2 . ILE A 1 9   ? 33.738 -93.480  29.398  1.00 95.04  ? 7   ILE A CG2 1 
ATOM 31   C CD1 . ILE A 1 9   ? 35.699 -94.679  31.366  1.00 111.61 ? 7   ILE A CD1 1 
ATOM 32   N N   . GLU A 1 10  ? 33.684 -90.881  27.491  1.00 82.86  ? 8   GLU A N   1 
ATOM 33   C CA  . GLU A 1 10  ? 32.563 -90.402  26.684  1.00 88.78  ? 8   GLU A CA  1 
ATOM 34   C C   . GLU A 1 10  ? 32.030 -91.535  25.802  1.00 87.31  ? 8   GLU A C   1 
ATOM 35   O O   . GLU A 1 10  ? 32.679 -92.565  25.642  1.00 80.03  ? 8   GLU A O   1 
ATOM 36   C CB  . GLU A 1 10  ? 32.948 -89.240  25.765  1.00 93.86  ? 8   GLU A CB  1 
ATOM 37   C CG  . GLU A 1 10  ? 33.280 -87.927  26.475  1.00 99.52  ? 8   GLU A CG  1 
ATOM 38   C CD  . GLU A 1 10  ? 33.555 -86.744  25.546  1.00 84.33  ? 8   GLU A CD  1 
ATOM 39   O OE1 . GLU A 1 10  ? 32.813 -86.690  24.542  1.00 78.16  ? 8   GLU A OE1 1 
ATOM 40   O OE2 . GLU A 1 10  ? 34.423 -85.864  25.814  1.00 61.94  ? 8   GLU A OE2 1 
ATOM 41   N N   . LYS A 1 11  ? 30.844 -91.316  25.213  1.00 90.05  ? 9   LYS A N   1 
ATOM 42   C CA  . LYS A 1 11  ? 30.161 -92.344  24.441  1.00 96.36  ? 9   LYS A CA  1 
ATOM 43   C C   . LYS A 1 11  ? 29.299 -91.727  23.328  1.00 102.44 ? 9   LYS A C   1 
ATOM 44   O O   . LYS A 1 11  ? 28.802 -90.605  23.461  1.00 92.27  ? 9   LYS A O   1 
ATOM 45   C CB  . LYS A 1 11  ? 29.322 -93.220  25.383  1.00 109.52 ? 9   LYS A CB  1 
ATOM 46   C CG  . LYS A 1 11  ? 30.091 -94.206  26.260  1.00 119.47 ? 9   LYS A CG  1 
ATOM 47   C CD  . LYS A 1 11  ? 29.258 -95.175  27.097  1.00 120.50 ? 9   LYS A CD  1 
ATOM 48   C CE  . LYS A 1 11  ? 30.098 -95.881  28.134  1.00 117.91 ? 9   LYS A CE  1 
ATOM 49   N NZ  . LYS A 1 11  ? 29.310 -96.588  29.141  1.00 118.35 ? 9   LYS A NZ  1 
ATOM 50   N N   . ASP A 1 12  ? 29.129 -92.485  22.228  1.00 114.71 ? 10  ASP A N   1 
ATOM 51   C CA  . ASP A 1 12  ? 28.142 -92.213  21.184  1.00 110.97 ? 10  ASP A CA  1 
ATOM 52   C C   . ASP A 1 12  ? 27.692 -93.560  20.604  1.00 101.33 ? 10  ASP A C   1 
ATOM 53   O O   . ASP A 1 12  ? 28.181 -94.597  21.048  1.00 79.22  ? 10  ASP A O   1 
ATOM 54   C CB  . ASP A 1 12  ? 28.649 -91.210  20.152  1.00 111.36 ? 10  ASP A CB  1 
ATOM 55   C CG  . ASP A 1 12  ? 29.770 -91.677  19.229  1.00 108.22 ? 10  ASP A CG  1 
ATOM 56   O OD1 . ASP A 1 12  ? 30.470 -92.653  19.568  1.00 90.82  ? 10  ASP A OD1 1 
ATOM 57   O OD2 . ASP A 1 12  ? 29.925 -91.076  18.147  1.00 109.59 ? 10  ASP A OD2 1 
ATOM 58   N N   . PHE A 1 13  ? 26.780 -93.564  19.608  1.00 98.44  ? 11  PHE A N   1 
ATOM 59   C CA  . PHE A 1 13  ? 26.051 -94.786  19.297  1.00 95.88  ? 11  PHE A CA  1 
ATOM 60   C C   . PHE A 1 13  ? 27.002 -95.892  18.811  1.00 94.32  ? 11  PHE A C   1 
ATOM 61   O O   . PHE A 1 13  ? 26.572 -97.023  18.619  1.00 89.13  ? 11  PHE A O   1 
ATOM 62   C CB  . PHE A 1 13  ? 24.802 -94.552  18.435  1.00 98.06  ? 11  PHE A CB  1 
ATOM 63   C CG  . PHE A 1 13  ? 24.887 -93.917  17.052  1.00 121.55 ? 11  PHE A CG  1 
ATOM 64   C CD1 . PHE A 1 13  ? 25.606 -94.505  16.006  1.00 133.86 ? 11  PHE A CD1 1 
ATOM 65   C CD2 . PHE A 1 13  ? 24.108 -92.801  16.763  1.00 120.54 ? 11  PHE A CD2 1 
ATOM 66   C CE1 . PHE A 1 13  ? 25.611 -93.941  14.736  1.00 127.84 ? 11  PHE A CE1 1 
ATOM 67   C CE2 . PHE A 1 13  ? 24.091 -92.254  15.482  1.00 118.40 ? 11  PHE A CE2 1 
ATOM 68   C CZ  . PHE A 1 13  ? 24.846 -92.820  14.474  1.00 123.62 ? 11  PHE A CZ  1 
ATOM 69   N N   . LEU A 1 14  ? 28.302 -95.621  18.651  1.00 105.77 ? 12  LEU A N   1 
ATOM 70   C CA  . LEU A 1 14  ? 29.258 -96.657  18.276  1.00 107.02 ? 12  LEU A CA  1 
ATOM 71   C C   . LEU A 1 14  ? 29.831 -97.316  19.530  1.00 95.71  ? 12  LEU A C   1 
ATOM 72   O O   . LEU A 1 14  ? 30.078 -98.511  19.524  1.00 89.31  ? 12  LEU A O   1 
ATOM 73   C CB  . LEU A 1 14  ? 30.337 -96.086  17.347  1.00 115.49 ? 12  LEU A CB  1 
ATOM 74   C CG  . LEU A 1 14  ? 29.802 -95.566  16.001  1.00 121.97 ? 12  LEU A CG  1 
ATOM 75   C CD1 . LEU A 1 14  ? 30.606 -94.381  15.529  1.00 136.60 ? 12  LEU A CD1 1 
ATOM 76   C CD2 . LEU A 1 14  ? 29.753 -96.605  14.891  1.00 114.83 ? 12  LEU A CD2 1 
ATOM 77   N N   . GLY A 1 15  ? 30.037 -96.550  20.609  1.00 105.32 ? 13  GLY A N   1 
ATOM 78   C CA  . GLY A 1 15  ? 30.556 -97.105  21.856  1.00 104.54 ? 13  GLY A CA  1 
ATOM 79   C C   . GLY A 1 15  ? 31.248 -96.053  22.724  1.00 95.41  ? 13  GLY A C   1 
ATOM 80   O O   . GLY A 1 15  ? 30.887 -94.881  22.669  1.00 83.93  ? 13  GLY A O   1 
ATOM 81   N N   . GLU A 1 16  ? 32.253 -96.487  23.501  1.00 95.01  ? 14  GLU A N   1 
ATOM 82   C CA  . GLU A 1 16  ? 32.858 -95.666  24.541  1.00 108.74 ? 14  GLU A CA  1 
ATOM 83   C C   . GLU A 1 16  ? 34.321 -95.378  24.229  1.00 102.70 ? 14  GLU A C   1 
ATOM 84   O O   . GLU A 1 16  ? 34.974 -96.201  23.602  1.00 110.85 ? 14  GLU A O   1 
ATOM 85   C CB  . GLU A 1 16  ? 32.782 -96.396  25.882  1.00 130.71 ? 14  GLU A CB  1 
ATOM 86   C CG  . GLU A 1 16  ? 33.539 -97.719  25.951  1.00 144.24 ? 14  GLU A CG  1 
ATOM 87   C CD  . GLU A 1 16  ? 33.431 -98.385  27.311  1.00 154.40 ? 14  GLU A CD  1 
ATOM 88   O OE1 . GLU A 1 16  ? 33.088 -97.708  28.313  1.00 157.08 ? 14  GLU A OE1 1 
ATOM 89   O OE2 . GLU A 1 16  ? 33.669 -99.612  27.359  1.00 148.69 ? 14  GLU A OE2 1 
ATOM 90   N N   . LYS A 1 17  ? 34.833 -94.229  24.691  1.00 99.54  ? 15  LYS A N   1 
ATOM 91   C CA  . LYS A 1 17  ? 36.238 -93.895  24.508  1.00 111.72 ? 15  LYS A CA  1 
ATOM 92   C C   . LYS A 1 17  ? 36.777 -93.131  25.716  1.00 106.49 ? 15  LYS A C   1 
ATOM 93   O O   . LYS A 1 17  ? 36.063 -92.377  26.370  1.00 89.75  ? 15  LYS A O   1 
ATOM 94   C CB  . LYS A 1 17  ? 36.470 -93.027  23.264  1.00 122.91 ? 15  LYS A CB  1 
ATOM 95   C CG  . LYS A 1 17  ? 36.179 -93.706  21.938  1.00 124.15 ? 15  LYS A CG  1 
ATOM 96   C CD  . LYS A 1 17  ? 37.126 -94.836  21.568  1.00 123.61 ? 15  LYS A CD  1 
ATOM 97   C CE  . LYS A 1 17  ? 36.743 -95.421  20.237  1.00 126.33 ? 15  LYS A CE  1 
ATOM 98   N NZ  . LYS A 1 17  ? 37.814 -96.233  19.654  1.00 125.00 ? 15  LYS A NZ  1 
ATOM 99   N N   . LYS A 1 18  ? 38.074 -93.321  25.973  1.00 105.40 ? 16  LYS A N   1 
ATOM 100  C CA  . LYS A 1 18  ? 38.810 -92.593  26.995  1.00 108.21 ? 16  LYS A CA  1 
ATOM 101  C C   . LYS A 1 18  ? 39.364 -91.297  26.397  1.00 101.93 ? 16  LYS A C   1 
ATOM 102  O O   . LYS A 1 18  ? 40.230 -91.316  25.527  1.00 95.85  ? 16  LYS A O   1 
ATOM 103  C CB  . LYS A 1 18  ? 39.931 -93.491  27.530  1.00 123.56 ? 16  LYS A CB  1 
ATOM 104  C CG  . LYS A 1 18  ? 39.480 -94.850  28.037  1.00 126.93 ? 16  LYS A CG  1 
ATOM 105  C CD  . LYS A 1 18  ? 40.598 -95.887  28.102  1.00 123.78 ? 16  LYS A CD  1 
ATOM 106  C CE  . LYS A 1 18  ? 40.077 -97.230  28.485  1.00 121.38 ? 16  LYS A CE  1 
ATOM 107  N NZ  . LYS A 1 18  ? 41.134 -98.244  28.447  1.00 117.16 ? 16  LYS A NZ  1 
ATOM 108  N N   . ILE A 1 19  ? 38.856 -90.159  26.875  1.00 98.99  ? 17  ILE A N   1 
ATOM 109  C CA  . ILE A 1 19  ? 39.358 -88.849  26.490  1.00 87.17  ? 17  ILE A CA  1 
ATOM 110  C C   . ILE A 1 19  ? 40.302 -88.375  27.584  1.00 98.81  ? 17  ILE A C   1 
ATOM 111  O O   . ILE A 1 19  ? 39.933 -88.416  28.757  1.00 123.33 ? 17  ILE A O   1 
ATOM 112  C CB  . ILE A 1 19  ? 38.221 -87.823  26.338  1.00 78.22  ? 17  ILE A CB  1 
ATOM 113  C CG1 . ILE A 1 19  ? 36.906 -88.451  25.839  1.00 77.95  ? 17  ILE A CG1 1 
ATOM 114  C CG2 . ILE A 1 19  ? 38.697 -86.654  25.472  1.00 80.36  ? 17  ILE A CG2 1 
ATOM 115  C CD1 . ILE A 1 19  ? 37.015 -89.199  24.517  1.00 82.16  ? 17  ILE A CD1 1 
ATOM 116  N N   . PRO A 1 20  ? 41.525 -87.893  27.273  1.00 106.27 ? 18  PRO A N   1 
ATOM 117  C CA  . PRO A 1 20  ? 42.287 -87.143  28.276  1.00 109.16 ? 18  PRO A CA  1 
ATOM 118  C C   . PRO A 1 20  ? 41.387 -86.057  28.868  1.00 100.50 ? 18  PRO A C   1 
ATOM 119  O O   . PRO A 1 20  ? 40.491 -85.559  28.191  1.00 95.85  ? 18  PRO A O   1 
ATOM 120  C CB  . PRO A 1 20  ? 43.497 -86.604  27.495  1.00 116.47 ? 18  PRO A CB  1 
ATOM 121  C CG  . PRO A 1 20  ? 43.662 -87.595  26.339  1.00 111.40 ? 18  PRO A CG  1 
ATOM 122  C CD  . PRO A 1 20  ? 42.253 -88.095  26.007  1.00 105.98 ? 18  PRO A CD  1 
ATOM 123  N N   . ALA A 1 21  ? 41.587 -85.738  30.152  1.00 102.16 ? 19  ALA A N   1 
ATOM 124  C CA  . ALA A 1 21  ? 40.734 -84.785  30.848  1.00 104.21 ? 19  ALA A CA  1 
ATOM 125  C C   . ALA A 1 21  ? 41.146 -83.355  30.507  1.00 102.53 ? 19  ALA A C   1 
ATOM 126  O O   . ALA A 1 21  ? 40.325 -82.442  30.594  1.00 90.90  ? 19  ALA A O   1 
ATOM 127  C CB  . ALA A 1 21  ? 40.796 -85.036  32.333  1.00 109.78 ? 19  ALA A CB  1 
ATOM 128  N N   . ASP A 1 22  ? 42.414 -83.182  30.109  1.00 95.34  ? 20  ASP A N   1 
ATOM 129  C CA  . ASP A 1 22  ? 42.912 -81.908  29.626  1.00 100.36 ? 20  ASP A CA  1 
ATOM 130  C C   . ASP A 1 22  ? 42.166 -81.474  28.367  1.00 99.39  ? 20  ASP A C   1 
ATOM 131  O O   . ASP A 1 22  ? 41.970 -80.280  28.124  1.00 99.90  ? 20  ASP A O   1 
ATOM 132  C CB  . ASP A 1 22  ? 44.406 -81.988  29.367  1.00 109.55 ? 20  ASP A CB  1 
ATOM 133  C CG  . ASP A 1 22  ? 45.251 -81.553  30.551  1.00 115.51 ? 20  ASP A CG  1 
ATOM 134  O OD1 . ASP A 1 22  ? 44.654 -81.371  31.633  1.00 110.04 ? 20  ASP A OD1 1 
ATOM 135  O OD2 . ASP A 1 22  ? 46.466 -81.358  30.360  1.00 122.69 ? 20  ASP A OD2 1 
ATOM 136  N N   . ALA A 1 23  ? 41.756 -82.470  27.580  1.00 98.46  ? 21  ALA A N   1 
ATOM 137  C CA  . ALA A 1 23  ? 41.285 -82.255  26.224  1.00 94.38  ? 21  ALA A CA  1 
ATOM 138  C C   . ALA A 1 23  ? 39.903 -81.605  26.198  1.00 83.23  ? 21  ALA A C   1 
ATOM 139  O O   . ALA A 1 23  ? 38.964 -82.107  26.820  1.00 79.51  ? 21  ALA A O   1 
ATOM 140  C CB  . ALA A 1 23  ? 41.280 -83.580  25.502  1.00 101.96 ? 21  ALA A CB  1 
ATOM 141  N N   . TYR A 1 24  ? 39.800 -80.513  25.423  1.00 77.62  ? 22  TYR A N   1 
ATOM 142  C CA  . TYR A 1 24  ? 38.536 -79.850  25.145  1.00 79.08  ? 22  TYR A CA  1 
ATOM 143  C C   . TYR A 1 24  ? 37.808 -80.564  24.011  1.00 77.40  ? 22  TYR A C   1 
ATOM 144  O O   . TYR A 1 24  ? 36.630 -80.316  23.785  1.00 78.98  ? 22  TYR A O   1 
ATOM 145  C CB  . TYR A 1 24  ? 38.700 -78.392  24.713  1.00 76.14  ? 22  TYR A CB  1 
ATOM 146  C CG  . TYR A 1 24  ? 39.288 -77.479  25.777  1.00 78.09  ? 22  TYR A CG  1 
ATOM 147  C CD1 . TYR A 1 24  ? 40.652 -77.487  26.055  1.00 80.61  ? 22  TYR A CD1 1 
ATOM 148  C CD2 . TYR A 1 24  ? 38.475 -76.591  26.484  1.00 77.70  ? 22  TYR A CD2 1 
ATOM 149  C CE1 . TYR A 1 24  ? 41.184 -76.634  27.011  1.00 89.49  ? 22  TYR A CE1 1 
ATOM 150  C CE2 . TYR A 1 24  ? 38.998 -75.735  27.442  1.00 85.11  ? 22  TYR A CE2 1 
ATOM 151  C CZ  . TYR A 1 24  ? 40.360 -75.758  27.701  1.00 89.54  ? 22  TYR A CZ  1 
ATOM 152  O OH  . TYR A 1 24  ? 40.916 -74.938  28.635  1.00 84.35  ? 22  TYR A OH  1 
ATOM 153  N N   . TYR A 1 25  ? 38.524 -81.429  23.290  1.00 69.23  ? 23  TYR A N   1 
ATOM 154  C CA  . TYR A 1 25  ? 37.945 -82.155  22.175  1.00 68.71  ? 23  TYR A CA  1 
ATOM 155  C C   . TYR A 1 25  ? 37.254 -83.419  22.679  1.00 69.19  ? 23  TYR A C   1 
ATOM 156  O O   . TYR A 1 25  ? 37.609 -83.953  23.719  1.00 79.51  ? 23  TYR A O   1 
ATOM 157  C CB  . TYR A 1 25  ? 39.074 -82.409  21.178  1.00 67.15  ? 23  TYR A CB  1 
ATOM 158  C CG  . TYR A 1 25  ? 40.176 -83.332  21.667  1.00 66.65  ? 23  TYR A CG  1 
ATOM 159  C CD1 . TYR A 1 25  ? 39.948 -84.704  21.801  1.00 69.52  ? 23  TYR A CD1 1 
ATOM 160  C CD2 . TYR A 1 25  ? 41.451 -82.843  21.942  1.00 60.85  ? 23  TYR A CD2 1 
ATOM 161  C CE1 . TYR A 1 25  ? 40.950 -85.563  22.222  1.00 69.22  ? 23  TYR A CE1 1 
ATOM 162  C CE2 . TYR A 1 25  ? 42.466 -83.696  22.358  1.00 64.29  ? 23  TYR A CE2 1 
ATOM 163  C CZ  . TYR A 1 25  ? 42.216 -85.056  22.485  1.00 69.11  ? 23  TYR A CZ  1 
ATOM 164  O OH  . TYR A 1 25  ? 43.197 -85.909  22.899  1.00 70.07  ? 23  TYR A OH  1 
ATOM 165  N N   . GLY A 1 26  ? 36.277 -83.909  21.917  1.00 74.91  ? 24  GLY A N   1 
ATOM 166  C CA  . GLY A 1 26  ? 35.400 -84.973  22.391  1.00 92.14  ? 24  GLY A CA  1 
ATOM 167  C C   . GLY A 1 26  ? 35.693 -86.312  21.716  1.00 88.66  ? 24  GLY A C   1 
ATOM 168  O O   . GLY A 1 26  ? 36.826 -86.549  21.320  1.00 95.35  ? 24  GLY A O   1 
ATOM 169  N N   . ILE A 1 27  ? 34.664 -87.167  21.605  1.00 78.70  ? 25  ILE A N   1 
ATOM 170  C CA  . ILE A 1 27  ? 34.821 -88.526  21.108  1.00 87.85  ? 25  ILE A CA  1 
ATOM 171  C C   . ILE A 1 27  ? 34.833 -88.509  19.583  1.00 108.03 ? 25  ILE A C   1 
ATOM 172  O O   . ILE A 1 27  ? 35.653 -89.184  18.961  1.00 125.42 ? 25  ILE A O   1 
ATOM 173  C CB  . ILE A 1 27  ? 33.723 -89.473  21.635  1.00 91.60  ? 25  ILE A CB  1 
ATOM 174  C CG1 . ILE A 1 27  ? 34.100 -90.938  21.374  1.00 90.77  ? 25  ILE A CG1 1 
ATOM 175  C CG2 . ILE A 1 27  ? 32.342 -89.144  21.057  1.00 89.01  ? 25  ILE A CG2 1 
ATOM 176  C CD1 . ILE A 1 27  ? 33.087 -91.961  21.865  1.00 91.15  ? 25  ILE A CD1 1 
ATOM 177  N N   . GLN A 1 28  ? 33.912 -87.749  18.979  1.00 104.21 ? 26  GLN A N   1 
ATOM 178  C CA  . GLN A 1 28  ? 33.793 -87.767  17.535  1.00 95.32  ? 26  GLN A CA  1 
ATOM 179  C C   . GLN A 1 28  ? 35.107 -87.281  16.920  1.00 97.64  ? 26  GLN A C   1 
ATOM 180  O O   . GLN A 1 28  ? 35.476 -87.725  15.843  1.00 106.70 ? 26  GLN A O   1 
ATOM 181  C CB  . GLN A 1 28  ? 32.543 -87.000  17.121  1.00 82.00  ? 26  GLN A CB  1 
ATOM 182  C CG  . GLN A 1 28  ? 31.261 -87.677  17.577  1.00 79.00  ? 26  GLN A CG  1 
ATOM 183  C CD  . GLN A 1 28  ? 30.041 -87.160  16.847  1.00 90.28  ? 26  GLN A CD  1 
ATOM 184  O OE1 . GLN A 1 28  ? 29.979 -87.174  15.613  1.00 96.10  ? 26  GLN A OE1 1 
ATOM 185  N NE2 . GLN A 1 28  ? 29.049 -86.696  17.593  1.00 94.48  ? 26  GLN A NE2 1 
ATOM 186  N N   . THR A 1 29  ? 35.823 -86.394  17.621  1.00 85.80  ? 27  THR A N   1 
ATOM 187  C CA  . THR A 1 29  ? 37.143 -85.962  17.199  1.00 73.46  ? 27  THR A CA  1 
ATOM 188  C C   . THR A 1 29  ? 38.158 -87.075  17.422  1.00 72.57  ? 27  THR A C   1 
ATOM 189  O O   . THR A 1 29  ? 39.073 -87.238  16.618  1.00 80.60  ? 27  THR A O   1 
ATOM 190  C CB  . THR A 1 29  ? 37.541 -84.690  17.946  1.00 67.65  ? 27  THR A CB  1 
ATOM 191  O OG1 . THR A 1 29  ? 36.705 -83.706  17.332  1.00 59.73  ? 27  THR A OG1 1 
ATOM 192  C CG2 . THR A 1 29  ? 39.022 -84.362  17.813  1.00 63.53  ? 27  THR A CG2 1 
ATOM 193  N N   . LEU A 1 30  ? 38.013 -87.816  18.519  1.00 72.46  ? 28  LEU A N   1 
ATOM 194  C CA  . LEU A 1 30  ? 38.948 -88.891  18.813  1.00 85.42  ? 28  LEU A CA  1 
ATOM 195  C C   . LEU A 1 30  ? 38.818 -89.965  17.739  1.00 87.52  ? 28  LEU A C   1 
ATOM 196  O O   . LEU A 1 30  ? 39.816 -90.464  17.229  1.00 86.38  ? 28  LEU A O   1 
ATOM 197  C CB  . LEU A 1 30  ? 38.722 -89.486  20.201  1.00 92.89  ? 28  LEU A CB  1 
ATOM 198  C CG  . LEU A 1 30  ? 39.849 -90.379  20.734  1.00 87.98  ? 28  LEU A CG  1 
ATOM 199  C CD1 . LEU A 1 30  ? 41.113 -89.557  20.954  1.00 77.85  ? 28  LEU A CD1 1 
ATOM 200  C CD2 . LEU A 1 30  ? 39.400 -91.081  22.008  1.00 97.05  ? 28  LEU A CD2 1 
ATOM 201  N N   . ARG A 1 31  ? 37.579 -90.263  17.352  1.00 85.61  ? 29  ARG A N   1 
ATOM 202  C CA  . ARG A 1 31  ? 37.353 -91.281  16.345  1.00 92.70  ? 29  ARG A CA  1 
ATOM 203  C C   . ARG A 1 31  ? 38.103 -90.909  15.063  1.00 85.19  ? 29  ARG A C   1 
ATOM 204  O O   . ARG A 1 31  ? 38.755 -91.753  14.450  1.00 70.82  ? 29  ARG A O   1 
ATOM 205  C CB  . ARG A 1 31  ? 35.849 -91.462  16.110  1.00 101.58 ? 29  ARG A CB  1 
ATOM 206  C CG  . ARG A 1 31  ? 35.069 -92.055  17.276  1.00 95.21  ? 29  ARG A CG  1 
ATOM 207  C CD  . ARG A 1 31  ? 33.842 -92.793  16.757  1.00 94.81  ? 29  ARG A CD  1 
ATOM 208  N NE  . ARG A 1 31  ? 33.017 -93.376  17.821  1.00 95.94  ? 29  ARG A NE  1 
ATOM 209  C CZ  . ARG A 1 31  ? 33.325 -94.447  18.538  1.00 99.47  ? 29  ARG A CZ  1 
ATOM 210  N NH1 . ARG A 1 31  ? 34.323 -95.223  18.158  1.00 103.30 ? 29  ARG A NH1 1 
ATOM 211  N NH2 . ARG A 1 31  ? 32.605 -94.753  19.608  1.00 97.07  ? 29  ARG A NH2 1 
ATOM 212  N N   . ALA A 1 32  ? 38.029 -89.627  14.686  1.00 81.71  ? 30  ALA A N   1 
ATOM 213  C CA  . ALA A 1 32  ? 38.534 -89.162  13.408  1.00 72.83  ? 30  ALA A CA  1 
ATOM 214  C C   . ALA A 1 32  ? 40.058 -89.127  13.425  1.00 74.25  ? 30  ALA A C   1 
ATOM 215  O O   . ALA A 1 32  ? 40.698 -89.359  12.398  1.00 75.29  ? 30  ALA A O   1 
ATOM 216  C CB  . ALA A 1 32  ? 37.963 -87.808  13.096  1.00 73.93  ? 30  ALA A CB  1 
ATOM 217  N N   . THR A 1 33  ? 40.636 -88.832  14.590  1.00 72.84  ? 31  THR A N   1 
ATOM 218  C CA  . THR A 1 33  ? 42.082 -88.874  14.733  1.00 68.71  ? 31  THR A CA  1 
ATOM 219  C C   . THR A 1 33  ? 42.569 -90.313  14.619  1.00 66.75  ? 31  THR A C   1 
ATOM 220  O O   . THR A 1 33  ? 43.688 -90.519  14.182  1.00 72.86  ? 31  THR A O   1 
ATOM 221  C CB  . THR A 1 33  ? 42.518 -88.222  16.042  1.00 65.19  ? 31  THR A CB  1 
ATOM 222  O OG1 . THR A 1 33  ? 41.649 -88.729  17.038  1.00 59.61  ? 31  THR A OG1 1 
ATOM 223  C CG2 . THR A 1 33  ? 42.327 -86.719  16.041  1.00 68.23  ? 31  THR A CG2 1 
ATOM 224  N N   . GLU A 1 34  ? 41.733 -91.294  14.983  1.00 69.65  ? 32  GLU A N   1 
ATOM 225  C CA  . GLU A 1 34  ? 42.075 -92.699  14.809  1.00 76.08  ? 32  GLU A CA  1 
ATOM 226  C C   . GLU A 1 34  ? 41.800 -93.123  13.366  1.00 68.38  ? 32  GLU A C   1 
ATOM 227  O O   . GLU A 1 34  ? 42.562 -93.901  12.784  1.00 63.25  ? 32  GLU A O   1 
ATOM 228  C CB  . GLU A 1 34  ? 41.276 -93.633  15.727  1.00 91.96  ? 32  GLU A CB  1 
ATOM 229  C CG  . GLU A 1 34  ? 41.653 -93.576  17.207  1.00 109.97 ? 32  GLU A CG  1 
ATOM 230  C CD  . GLU A 1 34  ? 40.758 -94.343  18.184  1.00 106.43 ? 32  GLU A CD  1 
ATOM 231  O OE1 . GLU A 1 34  ? 40.027 -95.300  17.837  1.00 84.71  ? 32  GLU A OE1 1 
ATOM 232  O OE2 . GLU A 1 34  ? 40.788 -93.928  19.358  1.00 105.51 ? 32  GLU A OE2 1 
ATOM 233  N N   . ASN A 1 35  ? 40.679 -92.629  12.823  1.00 62.30  ? 33  ASN A N   1 
ATOM 234  C CA  . ASN A 1 35  ? 40.175 -93.059  11.531  1.00 67.17  ? 33  ASN A CA  1 
ATOM 235  C C   . ASN A 1 35  ? 41.071 -92.542  10.408  1.00 70.37  ? 33  ASN A C   1 
ATOM 236  O O   . ASN A 1 35  ? 41.254 -93.231  9.404   1.00 65.39  ? 33  ASN A O   1 
ATOM 237  C CB  . ASN A 1 35  ? 38.740 -92.594  11.301  1.00 66.80  ? 33  ASN A CB  1 
ATOM 238  C CG  . ASN A 1 35  ? 37.710 -93.405  12.054  1.00 61.07  ? 33  ASN A CG  1 
ATOM 239  O OD1 . ASN A 1 35  ? 37.946 -94.581  12.354  1.00 50.23  ? 33  ASN A OD1 1 
ATOM 240  N ND2 . ASN A 1 35  ? 36.541 -92.819  12.299  1.00 59.30  ? 33  ASN A ND2 1 
ATOM 241  N N   . PHE A 1 36  ? 41.608 -91.325  10.584  1.00 70.49  ? 34  PHE A N   1 
ATOM 242  C CA  . PHE A 1 36  ? 42.285 -90.624  9.507   1.00 69.03  ? 34  PHE A CA  1 
ATOM 243  C C   . PHE A 1 36  ? 43.629 -90.091  9.984   1.00 68.54  ? 34  PHE A C   1 
ATOM 244  O O   . PHE A 1 36  ? 43.851 -88.883  10.016  1.00 72.46  ? 34  PHE A O   1 
ATOM 245  C CB  . PHE A 1 36  ? 41.381 -89.495  9.018   1.00 72.32  ? 34  PHE A CB  1 
ATOM 246  C CG  . PHE A 1 36  ? 39.952 -89.936  8.737   1.00 71.77  ? 34  PHE A CG  1 
ATOM 247  C CD1 . PHE A 1 36  ? 39.687 -91.088  8.006   1.00 72.10  ? 34  PHE A CD1 1 
ATOM 248  C CD2 . PHE A 1 36  ? 38.879 -89.213  9.244   1.00 70.30  ? 34  PHE A CD2 1 
ATOM 249  C CE1 . PHE A 1 36  ? 38.381 -91.478  7.767   1.00 75.64  ? 34  PHE A CE1 1 
ATOM 250  C CE2 . PHE A 1 36  ? 37.579 -89.610  9.005   1.00 68.10  ? 34  PHE A CE2 1 
ATOM 251  C CZ  . PHE A 1 36  ? 37.332 -90.734  8.263   1.00 72.26  ? 34  PHE A CZ  1 
ATOM 252  N N   . PRO A 1 37  ? 44.564 -90.991  10.350  1.00 69.89  ? 35  PRO A N   1 
ATOM 253  C CA  . PRO A 1 37  ? 45.934 -90.594  10.679  1.00 73.62  ? 35  PRO A CA  1 
ATOM 254  C C   . PRO A 1 37  ? 46.801 -90.476  9.430   1.00 72.64  ? 35  PRO A C   1 
ATOM 255  O O   . PRO A 1 37  ? 47.724 -91.252  9.246   1.00 78.92  ? 35  PRO A O   1 
ATOM 256  C CB  . PRO A 1 37  ? 46.344 -91.773  11.572  1.00 69.61  ? 35  PRO A CB  1 
ATOM 257  C CG  . PRO A 1 37  ? 45.685 -92.962  10.907  1.00 66.39  ? 35  PRO A CG  1 
ATOM 258  C CD  . PRO A 1 37  ? 44.344 -92.442  10.444  1.00 63.69  ? 35  PRO A CD  1 
ATOM 259  N N   . ILE A 1 38  ? 46.510 -89.493  8.580   1.00 64.58  ? 36  ILE A N   1 
ATOM 260  C CA  . ILE A 1 38  ? 46.980 -89.535  7.208   1.00 63.52  ? 36  ILE A CA  1 
ATOM 261  C C   . ILE A 1 38  ? 48.234 -88.689  7.027   1.00 62.29  ? 36  ILE A C   1 
ATOM 262  O O   . ILE A 1 38  ? 49.273 -89.230  6.689   1.00 79.75  ? 36  ILE A O   1 
ATOM 263  C CB  . ILE A 1 38  ? 45.858 -89.112  6.248   1.00 70.56  ? 36  ILE A CB  1 
ATOM 264  C CG1 . ILE A 1 38  ? 44.615 -89.984  6.418   1.00 75.02  ? 36  ILE A CG1 1 
ATOM 265  C CG2 . ILE A 1 38  ? 46.349 -89.113  4.802   1.00 75.01  ? 36  ILE A CG2 1 
ATOM 266  C CD1 . ILE A 1 38  ? 44.902 -91.479  6.405   1.00 70.98  ? 36  ILE A CD1 1 
ATOM 267  N N   . THR A 1 39  ? 48.121 -87.372  7.174   1.00 59.97  ? 37  THR A N   1 
ATOM 268  C CA  . THR A 1 39  ? 49.246 -86.471  7.000   1.00 58.18  ? 37  THR A CA  1 
ATOM 269  C C   . THR A 1 39  ? 49.783 -86.069  8.360   1.00 59.47  ? 37  THR A C   1 
ATOM 270  O O   . THR A 1 39  ? 50.929 -85.655  8.470   1.00 66.11  ? 37  THR A O   1 
ATOM 271  C CB  . THR A 1 39  ? 48.782 -85.216  6.265   1.00 62.53  ? 37  THR A CB  1 
ATOM 272  O OG1 . THR A 1 39  ? 47.754 -84.614  7.060   1.00 48.68  ? 37  THR A OG1 1 
ATOM 273  C CG2 . THR A 1 39  ? 48.311 -85.527  4.856   1.00 65.66  ? 37  THR A CG2 1 
ATOM 274  N N   . GLY A 1 40  ? 48.889 -86.121  9.353   1.00 62.25  ? 38  GLY A N   1 
ATOM 275  C CA  . GLY A 1 40  ? 49.096 -85.536  10.662  1.00 57.55  ? 38  GLY A CA  1 
ATOM 276  C C   . GLY A 1 40  ? 49.424 -84.051  10.575  1.00 56.34  ? 38  GLY A C   1 
ATOM 277  O O   . GLY A 1 40  ? 50.104 -83.536  11.438  1.00 59.33  ? 38  GLY A O   1 
ATOM 278  N N   . TYR A 1 41  ? 48.955 -83.351  9.543   1.00 61.54  ? 39  TYR A N   1 
ATOM 279  C CA  . TYR A 1 41  ? 48.979 -81.900  9.576   1.00 63.52  ? 39  TYR A CA  1 
ATOM 280  C C   . TYR A 1 41  ? 47.791 -81.440  10.414  1.00 60.20  ? 39  TYR A C   1 
ATOM 281  O O   . TYR A 1 41  ? 46.989 -82.266  10.861  1.00 56.05  ? 39  TYR A O   1 
ATOM 282  C CB  . TYR A 1 41  ? 48.932 -81.331  8.160   1.00 69.80  ? 39  TYR A CB  1 
ATOM 283  C CG  . TYR A 1 41  ? 50.152 -81.641  7.302   1.00 67.72  ? 39  TYR A CG  1 
ATOM 284  C CD1 . TYR A 1 41  ? 51.440 -81.483  7.787   1.00 67.56  ? 39  TYR A CD1 1 
ATOM 285  C CD2 . TYR A 1 41  ? 50.001 -82.094  6.002   1.00 66.23  ? 39  TYR A CD2 1 
ATOM 286  C CE1 . TYR A 1 41  ? 52.542 -81.739  6.994   1.00 75.36  ? 39  TYR A CE1 1 
ATOM 287  C CE2 . TYR A 1 41  ? 51.093 -82.375  5.206   1.00 70.48  ? 39  TYR A CE2 1 
ATOM 288  C CZ  . TYR A 1 41  ? 52.369 -82.196  5.701   1.00 76.02  ? 39  TYR A CZ  1 
ATOM 289  O OH  . TYR A 1 41  ? 53.451 -82.482  4.917   1.00 78.94  ? 39  TYR A OH  1 
ATOM 290  N N   . ARG A 1 42  ? 47.707 -80.129  10.654  1.00 59.08  ? 40  ARG A N   1 
ATOM 291  C CA  . ARG A 1 42  ? 46.528 -79.566  11.285  1.00 64.83  ? 40  ARG A CA  1 
ATOM 292  C C   . ARG A 1 42  ? 45.829 -78.664  10.287  1.00 60.06  ? 40  ARG A C   1 
ATOM 293  O O   . ARG A 1 42  ? 46.472 -78.096  9.418   1.00 69.90  ? 40  ARG A O   1 
ATOM 294  C CB  . ARG A 1 42  ? 46.843 -78.749  12.535  1.00 77.09  ? 40  ARG A CB  1 
ATOM 295  C CG  . ARG A 1 42  ? 47.489 -79.585  13.628  1.00 98.29  ? 40  ARG A CG  1 
ATOM 296  C CD  . ARG A 1 42  ? 46.564 -80.611  14.280  1.00 104.66 ? 40  ARG A CD  1 
ATOM 297  N NE  . ARG A 1 42  ? 47.327 -81.520  15.145  1.00 111.17 ? 40  ARG A NE  1 
ATOM 298  C CZ  . ARG A 1 42  ? 48.017 -81.174  16.229  1.00 103.72 ? 40  ARG A CZ  1 
ATOM 299  N NH1 . ARG A 1 42  ? 47.802 -79.986  16.773  1.00 95.89  ? 40  ARG A NH1 1 
ATOM 300  N NH2 . ARG A 1 42  ? 48.883 -82.024  16.770  1.00 104.36 ? 40  ARG A NH2 1 
ATOM 301  N N   . ILE A 1 43  ? 44.511 -78.554  10.436  1.00 57.53  ? 41  ILE A N   1 
ATOM 302  C CA  . ILE A 1 43  ? 43.706 -77.783  9.515   1.00 59.29  ? 41  ILE A CA  1 
ATOM 303  C C   . ILE A 1 43  ? 44.153 -76.326  9.599   1.00 61.73  ? 41  ILE A C   1 
ATOM 304  O O   . ILE A 1 43  ? 44.624 -75.875  10.639  1.00 67.31  ? 41  ILE A O   1 
ATOM 305  C CB  . ILE A 1 43  ? 42.208 -77.955  9.819   1.00 61.63  ? 41  ILE A CB  1 
ATOM 306  C CG1 . ILE A 1 43  ? 41.748 -77.091  10.971  1.00 62.20  ? 41  ILE A CG1 1 
ATOM 307  C CG2 . ILE A 1 43  ? 41.857 -79.421  10.055  1.00 63.72  ? 41  ILE A CG2 1 
ATOM 308  C CD1 . ILE A 1 43  ? 40.242 -76.935  11.029  1.00 68.42  ? 41  ILE A CD1 1 
ATOM 309  N N   . HIS A 1 44  ? 44.006 -75.593  8.494   1.00 64.48  ? 42  HIS A N   1 
ATOM 310  C CA  . HIS A 1 44  ? 44.605 -74.276  8.411   1.00 71.58  ? 42  HIS A CA  1 
ATOM 311  C C   . HIS A 1 44  ? 44.078 -73.428  9.566   1.00 63.20  ? 42  HIS A C   1 
ATOM 312  O O   . HIS A 1 44  ? 42.969 -73.641  10.040  1.00 48.65  ? 42  HIS A O   1 
ATOM 313  C CB  . HIS A 1 44  ? 44.419 -73.672  7.015   1.00 79.05  ? 42  HIS A CB  1 
ATOM 314  C CG  . HIS A 1 44  ? 45.291 -72.479  6.773   1.00 93.39  ? 42  HIS A CG  1 
ATOM 315  N ND1 . HIS A 1 44  ? 44.995 -71.224  7.265   1.00 97.22  ? 42  HIS A ND1 1 
ATOM 316  C CD2 . HIS A 1 44  ? 46.458 -72.356  6.123   1.00 101.60 ? 42  HIS A CD2 1 
ATOM 317  C CE1 . HIS A 1 44  ? 45.938 -70.368  6.896   1.00 95.61  ? 42  HIS A CE1 1 
ATOM 318  N NE2 . HIS A 1 44  ? 46.837 -71.038  6.207   1.00 108.39 ? 42  HIS A NE2 1 
ATOM 319  N N   . GLU A 1 45  ? 44.919 -72.499  10.031  1.00 65.74  ? 43  GLU A N   1 
ATOM 320  C CA  . GLU A 1 45  ? 44.609 -71.693  11.197  1.00 73.45  ? 43  GLU A CA  1 
ATOM 321  C C   . GLU A 1 45  ? 43.416 -70.811  10.874  1.00 60.79  ? 43  GLU A C   1 
ATOM 322  O O   . GLU A 1 45  ? 42.549 -70.564  11.701  1.00 65.93  ? 43  GLU A O   1 
ATOM 323  C CB  . GLU A 1 45  ? 45.832 -70.882  11.631  1.00 91.48  ? 43  GLU A CB  1 
ATOM 324  C CG  . GLU A 1 45  ? 46.999 -71.766  12.074  1.00 113.47 ? 43  GLU A CG  1 
ATOM 325  C CD  . GLU A 1 45  ? 46.689 -72.782  13.175  1.00 115.03 ? 43  GLU A CD  1 
ATOM 326  O OE1 . GLU A 1 45  ? 46.296 -72.354  14.288  1.00 120.57 ? 43  GLU A OE1 1 
ATOM 327  O OE2 . GLU A 1 45  ? 46.826 -74.006  12.927  1.00 99.28  ? 43  GLU A OE2 1 
ATOM 328  N N   . GLU A 1 46  ? 43.358 -70.392  9.628   1.00 58.85  ? 44  GLU A N   1 
ATOM 329  C CA  . GLU A 1 46  ? 42.397 -69.400  9.210   1.00 61.14  ? 44  GLU A CA  1 
ATOM 330  C C   . GLU A 1 46  ? 41.026 -70.056  9.056   1.00 54.02  ? 44  GLU A C   1 
ATOM 331  O O   . GLU A 1 46  ? 40.006 -69.377  9.121   1.00 52.65  ? 44  GLU A O   1 
ATOM 332  C CB  . GLU A 1 46  ? 43.035 -68.766  7.974   1.00 66.04  ? 44  GLU A CB  1 
ATOM 333  C CG  . GLU A 1 46  ? 42.402 -67.434  7.605   1.00 70.85  ? 44  GLU A CG  1 
ATOM 334  C CD  . GLU A 1 46  ? 42.352 -66.465  8.760   1.00 77.69  ? 44  GLU A CD  1 
ATOM 335  O OE1 . GLU A 1 46  ? 43.421 -66.210  9.359   1.00 86.22  ? 44  GLU A OE1 1 
ATOM 336  O OE2 . GLU A 1 46  ? 41.232 -65.979  9.039   1.00 92.05  ? 44  GLU A OE2 1 
ATOM 337  N N   . LEU A 1 47  ? 41.004 -71.377  8.863   1.00 47.23  ? 45  LEU A N   1 
ATOM 338  C CA  . LEU A 1 47  ? 39.756 -72.121  8.860   1.00 51.05  ? 45  LEU A CA  1 
ATOM 339  C C   . LEU A 1 47  ? 39.231 -72.243  10.292  1.00 59.64  ? 45  LEU A C   1 
ATOM 340  O O   . LEU A 1 47  ? 38.035 -72.136  10.532  1.00 66.85  ? 45  LEU A O   1 
ATOM 341  C CB  . LEU A 1 47  ? 39.962 -73.498  8.226   1.00 52.36  ? 45  LEU A CB  1 
ATOM 342  C CG  . LEU A 1 47  ? 38.727 -74.403  8.108   1.00 52.03  ? 45  LEU A CG  1 
ATOM 343  C CD1 . LEU A 1 47  ? 37.716 -73.755  7.199   1.00 56.86  ? 45  LEU A CD1 1 
ATOM 344  C CD2 . LEU A 1 47  ? 39.028 -75.788  7.572   1.00 50.04  ? 45  LEU A CD2 1 
ATOM 345  N N   . ILE A 1 48  ? 40.119 -72.498  11.252  1.00 64.48  ? 46  ILE A N   1 
ATOM 346  C CA  . ILE A 1 48  ? 39.699 -72.598  12.637  1.00 64.20  ? 46  ILE A CA  1 
ATOM 347  C C   . ILE A 1 48  ? 39.019 -71.289  13.031  1.00 59.92  ? 46  ILE A C   1 
ATOM 348  O O   . ILE A 1 48  ? 37.888 -71.314  13.518  1.00 59.87  ? 46  ILE A O   1 
ATOM 349  C CB  . ILE A 1 48  ? 40.877 -72.962  13.556  1.00 67.64  ? 46  ILE A CB  1 
ATOM 350  C CG1 . ILE A 1 48  ? 41.402 -74.362  13.273  1.00 65.25  ? 46  ILE A CG1 1 
ATOM 351  C CG2 . ILE A 1 48  ? 40.480 -72.822  15.020  1.00 68.83  ? 46  ILE A CG2 1 
ATOM 352  C CD1 . ILE A 1 48  ? 42.795 -74.590  13.824  1.00 71.22  ? 46  ILE A CD1 1 
ATOM 353  N N   . ARG A 1 49  ? 39.695 -70.160  12.768  1.00 55.50  ? 47  ARG A N   1 
ATOM 354  C CA  . ARG A 1 49  ? 39.130 -68.836  13.011  1.00 59.60  ? 47  ARG A CA  1 
ATOM 355  C C   . ARG A 1 49  ? 37.739 -68.731  12.387  1.00 54.83  ? 47  ARG A C   1 
ATOM 356  O O   . ARG A 1 49  ? 36.786 -68.270  13.002  1.00 45.56  ? 47  ARG A O   1 
ATOM 357  C CB  . ARG A 1 49  ? 40.024 -67.685  12.512  1.00 63.18  ? 47  ARG A CB  1 
ATOM 358  C CG  . ARG A 1 49  ? 41.194 -67.304  13.418  1.00 71.67  ? 47  ARG A CG  1 
ATOM 359  C CD  . ARG A 1 49  ? 41.859 -65.982  13.080  1.00 74.07  ? 47  ARG A CD  1 
ATOM 360  N NE  . ARG A 1 49  ? 40.827 -64.939  13.050  1.00 85.10  ? 47  ARG A NE  1 
ATOM 361  C CZ  . ARG A 1 49  ? 40.488 -64.169  12.008  1.00 106.95 ? 47  ARG A CZ  1 
ATOM 362  N NH1 . ARG A 1 49  ? 41.185 -64.190  10.888  1.00 120.85 ? 47  ARG A NH1 1 
ATOM 363  N NH2 . ARG A 1 49  ? 39.472 -63.323  12.091  1.00 119.39 ? 47  ARG A NH2 1 
ATOM 364  N N   . ALA A 1 50  ? 37.621 -69.171  11.144  1.00 62.02  ? 48  ALA A N   1 
ATOM 365  C CA  . ALA A 1 50  ? 36.376 -69.008  10.421  1.00 67.72  ? 48  ALA A CA  1 
ATOM 366  C C   . ALA A 1 50  ? 35.301 -69.873  11.056  1.00 59.46  ? 48  ALA A C   1 
ATOM 367  O O   . ALA A 1 50  ? 34.172 -69.433  11.214  1.00 61.76  ? 48  ALA A O   1 
ATOM 368  C CB  . ALA A 1 50  ? 36.582 -69.355  8.965   1.00 79.11  ? 48  ALA A CB  1 
ATOM 369  N N   . LEU A 1 51  ? 35.670 -71.102  11.412  1.00 56.76  ? 49  LEU A N   1 
ATOM 370  C CA  . LEU A 1 51  ? 34.744 -72.047  12.008  1.00 59.94  ? 49  LEU A CA  1 
ATOM 371  C C   . LEU A 1 51  ? 34.106 -71.434  13.245  1.00 65.77  ? 49  LEU A C   1 
ATOM 372  O O   . LEU A 1 51  ? 32.899 -71.580  13.435  1.00 61.74  ? 49  LEU A O   1 
ATOM 373  C CB  . LEU A 1 51  ? 35.503 -73.325  12.351  1.00 60.62  ? 49  LEU A CB  1 
ATOM 374  C CG  . LEU A 1 51  ? 35.691 -74.299  11.188  1.00 59.24  ? 49  LEU A CG  1 
ATOM 375  C CD1 . LEU A 1 51  ? 36.894 -75.181  11.467  1.00 57.78  ? 49  LEU A CD1 1 
ATOM 376  C CD2 . LEU A 1 51  ? 34.414 -75.111  10.967  1.00 57.44  ? 49  LEU A CD2 1 
ATOM 377  N N   . ALA A 1 52  ? 34.944 -70.749  14.046  1.00 68.23  ? 50  ALA A N   1 
ATOM 378  C CA  . ALA A 1 52  ? 34.511 -70.064  15.253  1.00 65.68  ? 50  ALA A CA  1 
ATOM 379  C C   . ALA A 1 52  ? 33.597 -68.888  14.923  1.00 66.99  ? 50  ALA A C   1 
ATOM 380  O O   . ALA A 1 52  ? 32.594 -68.701  15.601  1.00 80.53  ? 50  ALA A O   1 
ATOM 381  C CB  . ALA A 1 52  ? 35.700 -69.601  16.043  1.00 68.35  ? 50  ALA A CB  1 
ATOM 382  N N   . MET A 1 53  ? 33.930 -68.107  13.886  1.00 66.65  ? 51  MET A N   1 
ATOM 383  C CA  . MET A 1 53  ? 33.078 -67.006  13.452  1.00 66.40  ? 51  MET A CA  1 
ATOM 384  C C   . MET A 1 53  ? 31.675 -67.520  13.133  1.00 63.86  ? 51  MET A C   1 
ATOM 385  O O   . MET A 1 53  ? 30.690 -66.861  13.444  1.00 63.35  ? 51  MET A O   1 
ATOM 386  C CB  . MET A 1 53  ? 33.634 -66.304  12.208  1.00 66.20  ? 51  MET A CB  1 
ATOM 387  C CG  . MET A 1 53  ? 34.973 -65.636  12.444  1.00 69.67  ? 51  MET A CG  1 
ATOM 388  S SD  . MET A 1 53  ? 35.480 -64.575  11.080  1.00 69.16  ? 51  MET A SD  1 
ATOM 389  C CE  . MET A 1 53  ? 36.274 -63.182  11.897  1.00 81.26  ? 51  MET A CE  1 
ATOM 390  N N   . VAL A 1 54  ? 31.587 -68.707  12.527  1.00 58.03  ? 52  VAL A N   1 
ATOM 391  C CA  . VAL A 1 54  ? 30.314 -69.227  12.077  1.00 58.82  ? 52  VAL A CA  1 
ATOM 392  C C   . VAL A 1 54  ? 29.475 -69.679  13.263  1.00 63.50  ? 52  VAL A C   1 
ATOM 393  O O   . VAL A 1 54  ? 28.302 -69.334  13.332  1.00 61.55  ? 52  VAL A O   1 
ATOM 394  C CB  . VAL A 1 54  ? 30.539 -70.371  11.080  1.00 61.91  ? 52  VAL A CB  1 
ATOM 395  C CG1 . VAL A 1 54  ? 29.288 -71.210  10.871  1.00 65.14  ? 52  VAL A CG1 1 
ATOM 396  C CG2 . VAL A 1 54  ? 31.032 -69.812  9.759   1.00 66.41  ? 52  VAL A CG2 1 
ATOM 397  N N   . LYS A 1 55  ? 30.071 -70.470  14.164  1.00 71.62  ? 53  LYS A N   1 
ATOM 398  C CA  . LYS A 1 55  ? 29.352 -71.044  15.294  1.00 73.49  ? 53  LYS A CA  1 
ATOM 399  C C   . LYS A 1 55  ? 28.816 -69.928  16.193  1.00 77.69  ? 53  LYS A C   1 
ATOM 400  O O   . LYS A 1 55  ? 27.754 -70.092  16.813  1.00 79.53  ? 53  LYS A O   1 
ATOM 401  C CB  . LYS A 1 55  ? 30.265 -71.994  16.084  1.00 71.13  ? 53  LYS A CB  1 
ATOM 402  C CG  . LYS A 1 55  ? 30.724 -73.232  15.334  1.00 70.26  ? 53  LYS A CG  1 
ATOM 403  C CD  . LYS A 1 55  ? 29.565 -74.112  14.893  1.00 73.34  ? 53  LYS A CD  1 
ATOM 404  C CE  . LYS A 1 55  ? 29.987 -75.313  14.096  1.00 72.19  ? 53  LYS A CE  1 
ATOM 405  N NZ  . LYS A 1 55  ? 28.855 -76.213  13.840  1.00 69.00  ? 53  LYS A NZ  1 
ATOM 406  N N   . LYS A 1 56  ? 29.580 -68.820  16.244  1.00 69.97  ? 54  LYS A N   1 
ATOM 407  C CA  . LYS A 1 56  ? 29.217 -67.599  16.948  1.00 74.19  ? 54  LYS A CA  1 
ATOM 408  C C   . LYS A 1 56  ? 27.989 -66.951  16.301  1.00 70.73  ? 54  LYS A C   1 
ATOM 409  O O   . LYS A 1 56  ? 26.958 -66.792  16.947  1.00 67.83  ? 54  LYS A O   1 
ATOM 410  C CB  . LYS A 1 56  ? 30.418 -66.644  16.993  1.00 80.17  ? 54  LYS A CB  1 
ATOM 411  C CG  . LYS A 1 56  ? 30.102 -65.198  17.328  1.00 82.55  ? 54  LYS A CG  1 
ATOM 412  C CD  . LYS A 1 56  ? 31.295 -64.265  17.493  1.00 76.23  ? 54  LYS A CD  1 
ATOM 413  C CE  . LYS A 1 56  ? 30.773 -62.864  17.653  1.00 77.65  ? 54  LYS A CE  1 
ATOM 414  N NZ  . LYS A 1 56  ? 31.536 -62.017  18.570  1.00 84.68  ? 54  LYS A NZ  1 
ATOM 415  N N   . ALA A 1 57  ? 28.092 -66.578  15.023  1.00 66.86  ? 55  ALA A N   1 
ATOM 416  C CA  . ALA A 1 57  ? 26.942 -66.051  14.305  1.00 64.78  ? 55  ALA A CA  1 
ATOM 417  C C   . ALA A 1 57  ? 25.739 -66.977  14.482  1.00 61.99  ? 55  ALA A C   1 
ATOM 418  O O   . ALA A 1 57  ? 24.609 -66.507  14.531  1.00 65.16  ? 55  ALA A O   1 
ATOM 419  C CB  . ALA A 1 57  ? 27.271 -65.854  12.845  1.00 59.83  ? 55  ALA A CB  1 
ATOM 420  N N   . ALA A 1 58  ? 25.985 -68.286  14.583  1.00 61.38  ? 56  ALA A N   1 
ATOM 421  C CA  . ALA A 1 58  ? 24.916 -69.265  14.679  1.00 71.08  ? 56  ALA A CA  1 
ATOM 422  C C   . ALA A 1 58  ? 24.271 -69.211  16.060  1.00 75.65  ? 56  ALA A C   1 
ATOM 423  O O   . ALA A 1 58  ? 23.047 -69.164  16.187  1.00 75.03  ? 56  ALA A O   1 
ATOM 424  C CB  . ALA A 1 58  ? 25.435 -70.653  14.359  1.00 72.42  ? 56  ALA A CB  1 
ATOM 425  N N   . ALA A 1 59  ? 25.105 -69.239  17.096  1.00 80.57  ? 57  ALA A N   1 
ATOM 426  C CA  . ALA A 1 59  ? 24.612 -69.004  18.441  1.00 83.40  ? 57  ALA A CA  1 
ATOM 427  C C   . ALA A 1 59  ? 23.835 -67.685  18.490  1.00 73.71  ? 57  ALA A C   1 
ATOM 428  O O   . ALA A 1 59  ? 22.653 -67.696  18.817  1.00 74.11  ? 57  ALA A O   1 
ATOM 429  C CB  . ALA A 1 59  ? 25.761 -69.035  19.415  1.00 87.83  ? 57  ALA A CB  1 
ATOM 430  N N   . LEU A 1 60  ? 24.475 -66.566  18.116  1.00 67.87  ? 58  LEU A N   1 
ATOM 431  C CA  . LEU A 1 60  ? 23.851 -65.250  18.157  1.00 62.83  ? 58  LEU A CA  1 
ATOM 432  C C   . LEU A 1 60  ? 22.477 -65.302  17.515  1.00 70.16  ? 58  LEU A C   1 
ATOM 433  O O   . LEU A 1 60  ? 21.537 -64.727  18.047  1.00 95.28  ? 58  LEU A O   1 
ATOM 434  C CB  . LEU A 1 60  ? 24.672 -64.182  17.442  1.00 60.85  ? 58  LEU A CB  1 
ATOM 435  C CG  . LEU A 1 60  ? 25.931 -63.706  18.166  1.00 60.70  ? 58  LEU A CG  1 
ATOM 436  C CD1 . LEU A 1 60  ? 26.699 -62.758  17.284  1.00 62.76  ? 58  LEU A CD1 1 
ATOM 437  C CD2 . LEU A 1 60  ? 25.601 -63.052  19.489  1.00 56.86  ? 58  LEU A CD2 1 
ATOM 438  N N   . ALA A 1 61  ? 22.381 -65.949  16.354  1.00 73.63  ? 59  ALA A N   1 
ATOM 439  C CA  . ALA A 1 61  ? 21.129 -65.990  15.616  1.00 82.57  ? 59  ALA A CA  1 
ATOM 440  C C   . ALA A 1 61  ? 20.093 -66.850  16.340  1.00 80.41  ? 59  ALA A C   1 
ATOM 441  O O   . ALA A 1 61  ? 18.907 -66.539  16.293  1.00 83.21  ? 59  ALA A O   1 
ATOM 442  C CB  . ALA A 1 61  ? 21.372 -66.486  14.208  1.00 86.55  ? 59  ALA A CB  1 
ATOM 443  N N   . ASN A 1 62  ? 20.542 -67.927  16.997  1.00 83.55  ? 60  ASN A N   1 
ATOM 444  C CA  . ASN A 1 62  ? 19.634 -68.848  17.668  1.00 91.12  ? 60  ASN A CA  1 
ATOM 445  C C   . ASN A 1 62  ? 19.107 -68.244  18.971  1.00 87.13  ? 60  ASN A C   1 
ATOM 446  O O   . ASN A 1 62  ? 18.059 -68.668  19.459  1.00 86.52  ? 60  ASN A O   1 
ATOM 447  C CB  . ASN A 1 62  ? 20.278 -70.203  17.955  1.00 95.48  ? 60  ASN A CB  1 
ATOM 448  C CG  . ASN A 1 62  ? 20.521 -71.037  16.721  1.00 88.91  ? 60  ASN A CG  1 
ATOM 449  O OD1 . ASN A 1 62  ? 19.577 -71.316  15.970  1.00 82.67  ? 60  ASN A OD1 1 
ATOM 450  N ND2 . ASN A 1 62  ? 21.763 -71.465  16.524  1.00 88.66  ? 60  ASN A ND2 1 
ATOM 451  N N   . MET A 1 63  ? 19.842 -67.280  19.544  1.00 89.21  ? 61  MET A N   1 
ATOM 452  C CA  . MET A 1 63  ? 19.353 -66.518  20.686  1.00 92.02  ? 61  MET A CA  1 
ATOM 453  C C   . MET A 1 63  ? 18.333 -65.485  20.193  1.00 91.20  ? 61  MET A C   1 
ATOM 454  O O   . MET A 1 63  ? 17.225 -65.417  20.721  1.00 95.38  ? 61  MET A O   1 
ATOM 455  C CB  . MET A 1 63  ? 20.506 -65.881  21.481  1.00 84.24  ? 61  MET A CB  1 
ATOM 456  C CG  . MET A 1 63  ? 21.392 -66.908  22.203  1.00 81.39  ? 61  MET A CG  1 
ATOM 457  S SD  . MET A 1 63  ? 22.703 -66.246  23.263  1.00 71.07  ? 61  MET A SD  1 
ATOM 458  C CE  . MET A 1 63  ? 23.345 -64.864  22.307  1.00 81.48  ? 61  MET A CE  1 
ATOM 459  N N   . GLU A 1 64  ? 18.681 -64.738  19.136  1.00 85.60  ? 62  GLU A N   1 
ATOM 460  C CA  . GLU A 1 64  ? 17.802 -63.731  18.557  1.00 88.56  ? 62  GLU A CA  1 
ATOM 461  C C   . GLU A 1 64  ? 16.440 -64.293  18.159  1.00 97.32  ? 62  GLU A C   1 
ATOM 462  O O   . GLU A 1 64  ? 15.472 -63.543  18.108  1.00 116.54 ? 62  GLU A O   1 
ATOM 463  C CB  . GLU A 1 64  ? 18.380 -63.079  17.302  1.00 90.64  ? 62  GLU A CB  1 
ATOM 464  C CG  . GLU A 1 64  ? 18.834 -61.642  17.535  1.00 102.40 ? 62  GLU A CG  1 
ATOM 465  C CD  . GLU A 1 64  ? 19.850 -61.171  16.516  1.00 119.99 ? 62  GLU A CD  1 
ATOM 466  O OE1 . GLU A 1 64  ? 21.002 -61.625  16.643  1.00 146.81 ? 62  GLU A OE1 1 
ATOM 467  O OE2 . GLU A 1 64  ? 19.507 -60.398  15.598  1.00 132.91 ? 62  GLU A OE2 1 
ATOM 468  N N   . THR A 1 65  ? 16.365 -65.587  17.830  1.00 94.89  ? 63  THR A N   1 
ATOM 469  C CA  . THR A 1 65  ? 15.095 -66.200  17.466  1.00 88.83  ? 63  THR A CA  1 
ATOM 470  C C   . THR A 1 65  ? 14.578 -67.044  18.632  1.00 94.71  ? 63  THR A C   1 
ATOM 471  O O   . THR A 1 65  ? 13.721 -67.905  18.464  1.00 100.43 ? 63  THR A O   1 
ATOM 472  C CB  . THR A 1 65  ? 15.277 -67.003  16.181  1.00 84.34  ? 63  THR A CB  1 
ATOM 473  O OG1 . THR A 1 65  ? 16.196 -68.051  16.489  1.00 86.24  ? 63  THR A OG1 1 
ATOM 474  C CG2 . THR A 1 65  ? 15.774 -66.130  15.038  1.00 78.68  ? 63  THR A CG2 1 
ATOM 475  N N   . LYS A 1 66  ? 15.093 -66.761  19.832  1.00 100.53 ? 64  LYS A N   1 
ATOM 476  C CA  . LYS A 1 66  ? 14.480 -67.218  21.065  1.00 95.95  ? 64  LYS A CA  1 
ATOM 477  C C   . LYS A 1 66  ? 14.409 -68.744  21.088  1.00 89.11  ? 64  LYS A C   1 
ATOM 478  O O   . LYS A 1 66  ? 13.469 -69.269  21.667  1.00 91.12  ? 64  LYS A O   1 
ATOM 479  C CB  . LYS A 1 66  ? 13.048 -66.665  21.220  1.00 98.55  ? 64  LYS A CB  1 
ATOM 480  C CG  . LYS A 1 66  ? 12.725 -65.254  20.697  1.00 107.48 ? 64  LYS A CG  1 
ATOM 481  C CD  . LYS A 1 66  ? 13.014 -64.087  21.638  1.00 114.11 ? 64  LYS A CD  1 
ATOM 482  C CE  . LYS A 1 66  ? 14.467 -63.734  21.753  1.00 107.49 ? 64  LYS A CE  1 
ATOM 483  N NZ  . LYS A 1 66  ? 14.692 -62.701  22.770  1.00 102.67 ? 64  LYS A NZ  1 
ATOM 484  N N   . ARG A 1 67  ? 15.371 -69.450  20.471  1.00 88.22  ? 65  ARG A N   1 
ATOM 485  C CA  . ARG A 1 67  ? 15.348 -70.906  20.470  1.00 88.34  ? 65  ARG A CA  1 
ATOM 486  C C   . ARG A 1 67  ? 16.573 -71.477  21.189  1.00 83.89  ? 65  ARG A C   1 
ATOM 487  O O   . ARG A 1 67  ? 16.525 -72.586  21.708  1.00 84.52  ? 65  ARG A O   1 
ATOM 488  C CB  . ARG A 1 67  ? 15.097 -71.492  19.073  1.00 97.64  ? 65  ARG A CB  1 
ATOM 489  C CG  . ARG A 1 67  ? 15.923 -71.025  17.881  1.00 107.54 ? 65  ARG A CG  1 
ATOM 490  C CD  . ARG A 1 67  ? 15.506 -71.744  16.586  1.00 103.60 ? 65  ARG A CD  1 
ATOM 491  N NE  . ARG A 1 67  ? 15.624 -73.204  16.706  1.00 100.90 ? 65  ARG A NE  1 
ATOM 492  C CZ  . ARG A 1 67  ? 15.649 -74.073  15.705  1.00 109.75 ? 65  ARG A CZ  1 
ATOM 493  N NH1 . ARG A 1 67  ? 15.467 -73.674  14.452  1.00 126.70 ? 65  ARG A NH1 1 
ATOM 494  N NH2 . ARG A 1 67  ? 15.884 -75.351  15.960  1.00 101.06 ? 65  ARG A NH2 1 
ATOM 495  N N   . LEU A 1 68  ? 17.676 -70.727  21.242  1.00 84.71  ? 66  LEU A N   1 
ATOM 496  C CA  . LEU A 1 68  ? 18.796 -71.111  22.089  1.00 81.63  ? 66  LEU A CA  1 
ATOM 497  C C   . LEU A 1 68  ? 18.760 -70.256  23.351  1.00 77.64  ? 66  LEU A C   1 
ATOM 498  O O   . LEU A 1 68  ? 18.767 -69.026  23.252  1.00 76.53  ? 66  LEU A O   1 
ATOM 499  C CB  . LEU A 1 68  ? 20.136 -70.958  21.368  1.00 87.74  ? 66  LEU A CB  1 
ATOM 500  C CG  . LEU A 1 68  ? 21.397 -71.338  22.162  1.00 80.86  ? 66  LEU A CG  1 
ATOM 501  C CD1 . LEU A 1 68  ? 21.561 -72.853  22.341  1.00 74.74  ? 66  LEU A CD1 1 
ATOM 502  C CD2 . LEU A 1 68  ? 22.633 -70.740  21.500  1.00 75.44  ? 66  LEU A CD2 1 
ATOM 503  N N   . PRO A 1 69  ? 18.753 -70.872  24.561  1.00 70.77  ? 67  PRO A N   1 
ATOM 504  C CA  . PRO A 1 69  ? 18.881 -70.129  25.819  1.00 69.86  ? 67  PRO A CA  1 
ATOM 505  C C   . PRO A 1 69  ? 20.110 -69.225  25.892  1.00 74.77  ? 67  PRO A C   1 
ATOM 506  O O   . PRO A 1 69  ? 21.232 -69.687  25.680  1.00 77.33  ? 67  PRO A O   1 
ATOM 507  C CB  . PRO A 1 69  ? 18.981 -71.268  26.858  1.00 72.61  ? 67  PRO A CB  1 
ATOM 508  C CG  . PRO A 1 69  ? 19.476 -72.453  26.059  1.00 70.54  ? 67  PRO A CG  1 
ATOM 509  C CD  . PRO A 1 69  ? 18.655 -72.325  24.791  1.00 74.04  ? 67  PRO A CD  1 
ATOM 510  N N   . ALA A 1 70  ? 19.899 -67.954  26.261  1.00 78.37  ? 68  ALA A N   1 
ATOM 511  C CA  . ALA A 1 70  ? 20.977 -66.976  26.312  1.00 78.80  ? 68  ALA A CA  1 
ATOM 512  C C   . ALA A 1 70  ? 22.095 -67.412  27.268  1.00 69.38  ? 68  ALA A C   1 
ATOM 513  O O   . ALA A 1 70  ? 23.253 -67.054  27.075  1.00 65.12  ? 68  ALA A O   1 
ATOM 514  C CB  . ALA A 1 70  ? 20.412 -65.608  26.657  1.00 79.21  ? 68  ALA A CB  1 
ATOM 515  N N   . HIS A 1 71  ? 21.770 -68.193  28.299  1.00 75.72  ? 69  HIS A N   1 
ATOM 516  C CA  . HIS A 1 71  ? 22.803 -68.643  29.218  1.00 81.34  ? 69  HIS A CA  1 
ATOM 517  C C   . HIS A 1 71  ? 23.801 -69.561  28.510  1.00 79.61  ? 69  HIS A C   1 
ATOM 518  O O   . HIS A 1 71  ? 24.956 -69.559  28.905  1.00 84.26  ? 69  HIS A O   1 
ATOM 519  C CB  . HIS A 1 71  ? 22.232 -69.185  30.541  1.00 88.95  ? 69  HIS A CB  1 
ATOM 520  C CG  . HIS A 1 71  ? 21.843 -70.636  30.551  1.00 91.57  ? 69  HIS A CG  1 
ATOM 521  N ND1 . HIS A 1 71  ? 20.581 -71.002  30.131  1.00 89.91  ? 69  HIS A ND1 1 
ATOM 522  C CD2 . HIS A 1 71  ? 22.481 -71.788  30.908  1.00 82.55  ? 69  HIS A CD2 1 
ATOM 523  C CE1 . HIS A 1 71  ? 20.467 -72.325  30.217  1.00 94.26  ? 69  HIS A CE1 1 
ATOM 524  N NE2 . HIS A 1 71  ? 21.615 -72.824  30.672  1.00 87.62  ? 69  HIS A NE2 1 
ATOM 525  N N   . ILE A 1 72  ? 23.386 -70.352  27.504  1.00 81.67  ? 70  ILE A N   1 
ATOM 526  C CA  . ILE A 1 72  ? 24.295 -71.278  26.840  1.00 84.89  ? 70  ILE A CA  1 
ATOM 527  C C   . ILE A 1 72  ? 24.982 -70.537  25.699  1.00 82.69  ? 70  ILE A C   1 
ATOM 528  O O   . ILE A 1 72  ? 26.204 -70.573  25.573  1.00 82.86  ? 70  ILE A O   1 
ATOM 529  C CB  . ILE A 1 72  ? 23.577 -72.552  26.349  1.00 85.09  ? 70  ILE A CB  1 
ATOM 530  C CG1 . ILE A 1 72  ? 22.854 -73.277  27.471  1.00 87.41  ? 70  ILE A CG1 1 
ATOM 531  C CG2 . ILE A 1 72  ? 24.555 -73.500  25.663  1.00 89.17  ? 70  ILE A CG2 1 
ATOM 532  C CD1 . ILE A 1 72  ? 21.914 -74.361  26.992  1.00 87.94  ? 70  ILE A CD1 1 
ATOM 533  N N   . GLY A 1 73  ? 24.174 -69.843  24.896  1.00 83.22  ? 71  GLY A N   1 
ATOM 534  C CA  . GLY A 1 73  ? 24.653 -69.122  23.728  1.00 84.75  ? 71  GLY A CA  1 
ATOM 535  C C   . GLY A 1 73  ? 25.798 -68.155  24.034  1.00 79.17  ? 71  GLY A C   1 
ATOM 536  O O   . GLY A 1 73  ? 26.759 -68.072  23.273  1.00 72.27  ? 71  GLY A O   1 
ATOM 537  N N   . GLU A 1 74  ? 25.695 -67.420  25.145  1.00 78.35  ? 72  GLU A N   1 
ATOM 538  C CA  . GLU A 1 74  ? 26.696 -66.418  25.468  1.00 89.82  ? 72  GLU A CA  1 
ATOM 539  C C   . GLU A 1 74  ? 28.006 -67.112  25.847  1.00 79.05  ? 72  GLU A C   1 
ATOM 540  O O   . GLU A 1 74  ? 29.082 -66.597  25.550  1.00 82.10  ? 72  GLU A O   1 
ATOM 541  C CB  . GLU A 1 74  ? 26.155 -65.427  26.503  1.00 107.54 ? 72  GLU A CB  1 
ATOM 542  C CG  . GLU A 1 74  ? 25.228 -64.377  25.887  1.00 123.46 ? 72  GLU A CG  1 
ATOM 543  C CD  . GLU A 1 74  ? 24.325 -63.530  26.782  1.00 117.66 ? 72  GLU A CD  1 
ATOM 544  O OE1 . GLU A 1 74  ? 24.336 -63.629  28.036  1.00 103.68 ? 72  GLU A OE1 1 
ATOM 545  O OE2 . GLU A 1 74  ? 23.558 -62.747  26.170  1.00 108.71 ? 72  GLU A OE2 1 
ATOM 546  N N   . ALA A 1 75  ? 27.908 -68.296  26.459  1.00 70.88  ? 73  ALA A N   1 
ATOM 547  C CA  . ALA A 1 75  ? 29.086 -69.076  26.820  1.00 80.75  ? 73  ALA A CA  1 
ATOM 548  C C   . ALA A 1 75  ? 29.795 -69.577  25.571  1.00 79.80  ? 73  ALA A C   1 
ATOM 549  O O   . ALA A 1 75  ? 31.020 -69.614  25.527  1.00 79.10  ? 73  ALA A O   1 
ATOM 550  C CB  . ALA A 1 75  ? 28.712 -70.252  27.697  1.00 90.13  ? 73  ALA A CB  1 
ATOM 551  N N   . ILE A 1 76  ? 28.983 -70.005  24.598  1.00 86.76  ? 74  ILE A N   1 
ATOM 552  C CA  . ILE A 1 76  ? 29.450 -70.404  23.281  1.00 81.76  ? 74  ILE A CA  1 
ATOM 553  C C   . ILE A 1 76  ? 30.127 -69.212  22.606  1.00 71.41  ? 74  ILE A C   1 
ATOM 554  O O   . ILE A 1 76  ? 31.306 -69.293  22.248  1.00 65.42  ? 74  ILE A O   1 
ATOM 555  C CB  . ILE A 1 76  ? 28.268 -70.954  22.463  1.00 79.28  ? 74  ILE A CB  1 
ATOM 556  C CG1 . ILE A 1 76  ? 27.812 -72.300  22.994  1.00 77.63  ? 74  ILE A CG1 1 
ATOM 557  C CG2 . ILE A 1 76  ? 28.609 -71.036  20.981  1.00 82.40  ? 74  ILE A CG2 1 
ATOM 558  C CD1 . ILE A 1 76  ? 26.460 -72.733  22.452  1.00 78.72  ? 74  ILE A CD1 1 
ATOM 559  N N   . VAL A 1 77  ? 29.383 -68.103  22.477  1.00 61.08  ? 75  VAL A N   1 
ATOM 560  C CA  . VAL A 1 77  ? 29.905 -66.885  21.873  1.00 59.67  ? 75  VAL A CA  1 
ATOM 561  C C   . VAL A 1 77  ? 31.234 -66.518  22.522  1.00 58.81  ? 75  VAL A C   1 
ATOM 562  O O   . VAL A 1 77  ? 32.154 -66.078  21.848  1.00 65.27  ? 75  VAL A O   1 
ATOM 563  C CB  . VAL A 1 77  ? 28.941 -65.690  21.959  1.00 58.43  ? 75  VAL A CB  1 
ATOM 564  C CG1 . VAL A 1 77  ? 29.614 -64.383  21.553  1.00 56.70  ? 75  VAL A CG1 1 
ATOM 565  C CG2 . VAL A 1 77  ? 27.696 -65.930  21.121  1.00 61.73  ? 75  VAL A CG2 1 
ATOM 566  N N   . ALA A 1 78  ? 31.314 -66.667  23.840  1.00 62.31  ? 76  ALA A N   1 
ATOM 567  C CA  . ALA A 1 78  ? 32.524 -66.319  24.559  1.00 63.80  ? 76  ALA A CA  1 
ATOM 568  C C   . ALA A 1 78  ? 33.671 -67.207  24.100  1.00 60.83  ? 76  ALA A C   1 
ATOM 569  O O   . ALA A 1 78  ? 34.779 -66.728  23.919  1.00 62.13  ? 76  ALA A O   1 
ATOM 570  C CB  . ALA A 1 78  ? 32.288 -66.466  26.039  1.00 69.18  ? 76  ALA A CB  1 
ATOM 571  N N   . ALA A 1 79  ? 33.380 -68.498  23.927  1.00 65.52  ? 77  ALA A N   1 
ATOM 572  C CA  . ALA A 1 79  ? 34.394 -69.485  23.600  1.00 71.40  ? 77  ALA A CA  1 
ATOM 573  C C   . ALA A 1 79  ? 34.829 -69.283  22.156  1.00 77.14  ? 77  ALA A C   1 
ATOM 574  O O   . ALA A 1 79  ? 36.017 -69.321  21.853  1.00 81.39  ? 77  ALA A O   1 
ATOM 575  C CB  . ALA A 1 79  ? 33.871 -70.887  23.845  1.00 72.84  ? 77  ALA A CB  1 
ATOM 576  N N   . CYS A 1 80  ? 33.857 -69.050  21.271  1.00 76.46  ? 78  CYS A N   1 
ATOM 577  C CA  . CYS A 1 80  ? 34.161 -68.706  19.890  1.00 75.65  ? 78  CYS A CA  1 
ATOM 578  C C   . CYS A 1 80  ? 35.145 -67.538  19.841  1.00 64.83  ? 78  CYS A C   1 
ATOM 579  O O   . CYS A 1 80  ? 36.189 -67.614  19.195  1.00 57.42  ? 78  CYS A O   1 
ATOM 580  C CB  . CYS A 1 80  ? 32.891 -68.346  19.135  1.00 80.10  ? 78  CYS A CB  1 
ATOM 581  S SG  . CYS A 1 80  ? 31.830 -69.780  18.836  1.00 86.30  ? 78  CYS A SG  1 
ATOM 582  N N   . ASP A 1 81  ? 34.802 -66.467  20.561  1.00 57.85  ? 79  ASP A N   1 
ATOM 583  C CA  . ASP A 1 81  ? 35.541 -65.226  20.493  1.00 58.22  ? 79  ASP A CA  1 
ATOM 584  C C   . ASP A 1 81  ? 37.001 -65.473  20.841  1.00 60.20  ? 79  ASP A C   1 
ATOM 585  O O   . ASP A 1 81  ? 37.870 -64.784  20.320  1.00 75.08  ? 79  ASP A O   1 
ATOM 586  C CB  . ASP A 1 81  ? 34.904 -64.155  21.359  1.00 65.60  ? 79  ASP A CB  1 
ATOM 587  C CG  . ASP A 1 81  ? 33.878 -63.283  20.656  1.00 76.39  ? 79  ASP A CG  1 
ATOM 588  O OD1 . ASP A 1 81  ? 34.246 -62.688  19.619  1.00 88.78  ? 79  ASP A OD1 1 
ATOM 589  O OD2 . ASP A 1 81  ? 32.735 -63.182  21.163  1.00 83.00  ? 79  ASP A OD2 1 
ATOM 590  N N   . GLU A 1 82  ? 37.255 -66.444  21.721  1.00 59.73  ? 80  GLU A N   1 
ATOM 591  C CA  . GLU A 1 82  ? 38.603 -66.784  22.151  1.00 67.42  ? 80  GLU A CA  1 
ATOM 592  C C   . GLU A 1 82  ? 39.346 -67.521  21.040  1.00 67.67  ? 80  GLU A C   1 
ATOM 593  O O   . GLU A 1 82  ? 40.519 -67.261  20.801  1.00 69.97  ? 80  GLU A O   1 
ATOM 594  C CB  . GLU A 1 82  ? 38.576 -67.633  23.423  1.00 70.81  ? 80  GLU A CB  1 
ATOM 595  C CG  . GLU A 1 82  ? 38.190 -66.840  24.667  1.00 72.34  ? 80  GLU A CG  1 
ATOM 596  C CD  . GLU A 1 82  ? 38.016 -67.661  25.931  1.00 71.85  ? 80  GLU A CD  1 
ATOM 597  O OE1 . GLU A 1 82  ? 38.048 -68.909  25.955  1.00 67.35  ? 80  GLU A OE1 1 
ATOM 598  O OE2 . GLU A 1 82  ? 37.851 -66.971  26.935  1.00 79.67  ? 80  GLU A OE2 1 
ATOM 599  N N   . ILE A 1 83  ? 38.658 -68.457  20.385  1.00 65.63  ? 81  ILE A N   1 
ATOM 600  C CA  . ILE A 1 83  ? 39.232 -69.207  19.285  1.00 59.63  ? 81  ILE A CA  1 
ATOM 601  C C   . ILE A 1 83  ? 39.537 -68.229  18.153  1.00 52.52  ? 81  ILE A C   1 
ATOM 602  O O   . ILE A 1 83  ? 40.604 -68.301  17.554  1.00 47.63  ? 81  ILE A O   1 
ATOM 603  C CB  . ILE A 1 83  ? 38.285 -70.342  18.865  1.00 65.20  ? 81  ILE A CB  1 
ATOM 604  C CG1 . ILE A 1 83  ? 38.026 -71.311  20.029  1.00 69.40  ? 81  ILE A CG1 1 
ATOM 605  C CG2 . ILE A 1 83  ? 38.829 -71.069  17.643  1.00 71.24  ? 81  ILE A CG2 1 
ATOM 606  C CD1 . ILE A 1 83  ? 36.996 -72.393  19.754  1.00 69.45  ? 81  ILE A CD1 1 
ATOM 607  N N   . ILE A 1 84  ? 38.621 -67.285  17.902  1.00 54.57  ? 82  ILE A N   1 
ATOM 608  C CA  . ILE A 1 84  ? 38.844 -66.199  16.946  1.00 57.25  ? 82  ILE A CA  1 
ATOM 609  C C   . ILE A 1 84  ? 40.119 -65.416  17.293  1.00 58.60  ? 82  ILE A C   1 
ATOM 610  O O   . ILE A 1 84  ? 40.899 -65.028  16.414  1.00 49.01  ? 82  ILE A O   1 
ATOM 611  C CB  . ILE A 1 84  ? 37.637 -65.244  16.890  1.00 52.84  ? 82  ILE A CB  1 
ATOM 612  C CG1 . ILE A 1 84  ? 36.396 -65.930  16.341  1.00 59.99  ? 82  ILE A CG1 1 
ATOM 613  C CG2 . ILE A 1 84  ? 37.995 -63.998  16.088  1.00 48.89  ? 82  ILE A CG2 1 
ATOM 614  C CD1 . ILE A 1 84  ? 35.138 -65.073  16.362  1.00 63.91  ? 82  ILE A CD1 1 
ATOM 615  N N   . ALA A 1 85  ? 40.277 -65.154  18.596  1.00 62.06  ? 83  ALA A N   1 
ATOM 616  C CA  . ALA A 1 85  ? 41.384 -64.385  19.124  1.00 60.09  ? 83  ALA A CA  1 
ATOM 617  C C   . ALA A 1 85  ? 42.659 -65.210  19.066  1.00 57.80  ? 83  ALA A C   1 
ATOM 618  O O   . ALA A 1 85  ? 43.740 -64.650  19.099  1.00 56.39  ? 83  ALA A O   1 
ATOM 619  C CB  . ALA A 1 85  ? 41.070 -63.961  20.534  1.00 64.12  ? 83  ALA A CB  1 
ATOM 620  N N   . GLY A 1 86  ? 42.515 -66.534  19.008  1.00 64.88  ? 84  GLY A N   1 
ATOM 621  C CA  . GLY A 1 86  ? 43.596 -67.430  18.630  1.00 70.66  ? 84  GLY A CA  1 
ATOM 622  C C   . GLY A 1 86  ? 43.972 -68.371  19.766  1.00 70.78  ? 84  GLY A C   1 
ATOM 623  O O   . GLY A 1 86  ? 45.108 -68.821  19.839  1.00 67.03  ? 84  GLY A O   1 
ATOM 624  N N   . GLN A 1 87  ? 43.002 -68.690  20.628  1.00 79.21  ? 85  GLN A N   1 
ATOM 625  C CA  . GLN A 1 87  ? 43.313 -69.423  21.838  1.00 93.07  ? 85  GLN A CA  1 
ATOM 626  C C   . GLN A 1 87  ? 43.422 -70.897  21.482  1.00 91.20  ? 85  GLN A C   1 
ATOM 627  O O   . GLN A 1 87  ? 44.529 -71.431  21.444  1.00 108.46 ? 85  GLN A O   1 
ATOM 628  C CB  . GLN A 1 87  ? 42.376 -69.073  22.999  1.00 98.56  ? 85  GLN A CB  1 
ATOM 629  C CG  . GLN A 1 87  ? 42.775 -67.789  23.731  1.00 88.00  ? 85  GLN A CG  1 
ATOM 630  C CD  . GLN A 1 87  ? 41.861 -67.396  24.874  1.00 74.89  ? 85  GLN A CD  1 
ATOM 631  O OE1 . GLN A 1 87  ? 41.139 -68.221  25.452  1.00 84.01  ? 85  GLN A OE1 1 
ATOM 632  N NE2 . GLN A 1 87  ? 41.887 -66.117  25.218  1.00 68.44  ? 85  GLN A NE2 1 
ATOM 633  N N   . TRP A 1 88  ? 42.300 -71.543  21.172  1.00 74.11  ? 86  TRP A N   1 
ATOM 634  C CA  . TRP A 1 88  ? 42.243 -72.969  21.458  1.00 80.23  ? 86  TRP A CA  1 
ATOM 635  C C   . TRP A 1 88  ? 42.644 -73.838  20.271  1.00 76.26  ? 86  TRP A C   1 
ATOM 636  O O   . TRP A 1 88  ? 42.186 -74.978  20.149  1.00 67.47  ? 86  TRP A O   1 
ATOM 637  C CB  . TRP A 1 88  ? 40.854 -73.309  22.001  1.00 84.49  ? 86  TRP A CB  1 
ATOM 638  C CG  . TRP A 1 88  ? 40.566 -72.470  23.213  1.00 78.56  ? 86  TRP A CG  1 
ATOM 639  C CD1 . TRP A 1 88  ? 39.790 -71.354  23.291  1.00 78.38  ? 86  TRP A CD1 1 
ATOM 640  C CD2 . TRP A 1 88  ? 41.170 -72.637  24.510  1.00 71.58  ? 86  TRP A CD2 1 
ATOM 641  N NE1 . TRP A 1 88  ? 39.826 -70.845  24.561  1.00 73.12  ? 86  TRP A NE1 1 
ATOM 642  C CE2 . TRP A 1 88  ? 40.676 -71.597  25.324  1.00 69.27  ? 86  TRP A CE2 1 
ATOM 643  C CE3 . TRP A 1 88  ? 42.059 -73.571  25.052  1.00 73.65  ? 86  TRP A CE3 1 
ATOM 644  C CZ2 . TRP A 1 88  ? 41.045 -71.464  26.655  1.00 66.36  ? 86  TRP A CZ2 1 
ATOM 645  C CZ3 . TRP A 1 88  ? 42.434 -73.437  26.364  1.00 75.05  ? 86  TRP A CZ3 1 
ATOM 646  C CH2 . TRP A 1 88  ? 41.932 -72.396  27.146  1.00 76.68  ? 86  TRP A CH2 1 
ATOM 647  N N   . HIS A 1 89  ? 43.573 -73.327  19.454  1.00 73.18  ? 87  HIS A N   1 
ATOM 648  C CA  . HIS A 1 89  ? 43.870 -73.950  18.177  1.00 65.06  ? 87  HIS A CA  1 
ATOM 649  C C   . HIS A 1 89  ? 44.482 -75.319  18.431  1.00 65.87  ? 87  HIS A C   1 
ATOM 650  O O   . HIS A 1 89  ? 44.185 -76.233  17.662  1.00 62.37  ? 87  HIS A O   1 
ATOM 651  C CB  . HIS A 1 89  ? 44.693 -73.021  17.281  1.00 63.53  ? 87  HIS A CB  1 
ATOM 652  C CG  . HIS A 1 89  ? 43.938 -71.801  16.867  1.00 64.15  ? 87  HIS A CG  1 
ATOM 653  N ND1 . HIS A 1 89  ? 44.441 -70.825  16.044  1.00 69.00  ? 87  HIS A ND1 1 
ATOM 654  C CD2 . HIS A 1 89  ? 42.727 -71.364  17.224  1.00 67.20  ? 87  HIS A CD2 1 
ATOM 655  C CE1 . HIS A 1 89  ? 43.558 -69.845  15.917  1.00 68.55  ? 87  HIS A CE1 1 
ATOM 656  N NE2 . HIS A 1 89  ? 42.503 -70.164  16.602  1.00 69.88  ? 87  HIS A NE2 1 
ATOM 657  N N   . ASP A 1 90  ? 45.266 -75.457  19.524  1.00 71.07  ? 88  ASP A N   1 
ATOM 658  C CA  . ASP A 1 90  ? 45.968 -76.699  19.838  1.00 73.79  ? 88  ASP A CA  1 
ATOM 659  C C   . ASP A 1 90  ? 44.996 -77.882  19.837  1.00 66.57  ? 88  ASP A C   1 
ATOM 660  O O   . ASP A 1 90  ? 45.361 -78.998  19.480  1.00 59.39  ? 88  ASP A O   1 
ATOM 661  C CB  . ASP A 1 90  ? 46.663 -76.648  21.190  1.00 84.85  ? 88  ASP A CB  1 
ATOM 662  C CG  . ASP A 1 90  ? 47.714 -75.575  21.443  1.00 99.59  ? 88  ASP A CG  1 
ATOM 663  O OD1 . ASP A 1 90  ? 48.123 -74.835  20.526  1.00 120.39 ? 88  ASP A OD1 1 
ATOM 664  O OD2 . ASP A 1 90  ? 48.138 -75.494  22.588  1.00 104.57 ? 88  ASP A OD2 1 
ATOM 665  N N   . GLN A 1 91  ? 43.736 -77.606  20.202  1.00 72.19  ? 89  GLN A N   1 
ATOM 666  C CA  . GLN A 1 91  ? 42.714 -78.624  20.386  1.00 70.56  ? 89  GLN A CA  1 
ATOM 667  C C   . GLN A 1 91  ? 42.235 -79.188  19.053  1.00 75.68  ? 89  GLN A C   1 
ATOM 668  O O   . GLN A 1 91  ? 41.898 -80.366  18.991  1.00 80.73  ? 89  GLN A O   1 
ATOM 669  C CB  . GLN A 1 91  ? 41.563 -78.036  21.195  1.00 70.20  ? 89  GLN A CB  1 
ATOM 670  C CG  . GLN A 1 91  ? 41.931 -77.756  22.645  1.00 69.78  ? 89  GLN A CG  1 
ATOM 671  C CD  . GLN A 1 91  ? 42.414 -78.996  23.362  1.00 71.62  ? 89  GLN A CD  1 
ATOM 672  O OE1 . GLN A 1 91  ? 41.694 -79.982  23.550  1.00 80.53  ? 89  GLN A OE1 1 
ATOM 673  N NE2 . GLN A 1 91  ? 43.657 -78.952  23.798  1.00 80.97  ? 89  GLN A NE2 1 
ATOM 674  N N   . PHE A 1 92  ? 42.205 -78.362  18.005  1.00 80.23  ? 90  PHE A N   1 
ATOM 675  C CA  . PHE A 1 92  ? 41.858 -78.830  16.670  1.00 74.79  ? 90  PHE A CA  1 
ATOM 676  C C   . PHE A 1 92  ? 42.928 -79.823  16.225  1.00 71.69  ? 90  PHE A C   1 
ATOM 677  O O   . PHE A 1 92  ? 44.091 -79.442  16.124  1.00 71.72  ? 90  PHE A O   1 
ATOM 678  C CB  . PHE A 1 92  ? 41.704 -77.579  15.800  1.00 71.01  ? 90  PHE A CB  1 
ATOM 679  C CG  . PHE A 1 92  ? 40.474 -76.773  16.180  1.00 64.70  ? 90  PHE A CG  1 
ATOM 680  C CD1 . PHE A 1 92  ? 40.528 -75.845  17.206  1.00 68.21  ? 90  PHE A CD1 1 
ATOM 681  C CD2 . PHE A 1 92  ? 39.264 -76.977  15.532  1.00 63.63  ? 90  PHE A CD2 1 
ATOM 682  C CE1 . PHE A 1 92  ? 39.391 -75.135  17.560  1.00 75.39  ? 90  PHE A CE1 1 
ATOM 683  C CE2 . PHE A 1 92  ? 38.137 -76.253  15.875  1.00 65.74  ? 90  PHE A CE2 1 
ATOM 684  C CZ  . PHE A 1 92  ? 38.204 -75.324  16.879  1.00 70.42  ? 90  PHE A CZ  1 
ATOM 685  N N   . ILE A 1 93  ? 42.545 -81.096  16.060  1.00 70.69  ? 91  ILE A N   1 
ATOM 686  C CA  . ILE A 1 93  ? 43.520 -82.164  15.896  1.00 74.40  ? 91  ILE A CA  1 
ATOM 687  C C   . ILE A 1 93  ? 43.107 -83.142  14.802  1.00 72.13  ? 91  ILE A C   1 
ATOM 688  O O   . ILE A 1 93  ? 43.774 -84.158  14.638  1.00 80.20  ? 91  ILE A O   1 
ATOM 689  C CB  . ILE A 1 93  ? 43.756 -82.920  17.217  1.00 69.88  ? 91  ILE A CB  1 
ATOM 690  C CG1 . ILE A 1 93  ? 42.458 -83.576  17.724  1.00 70.77  ? 91  ILE A CG1 1 
ATOM 691  C CG2 . ILE A 1 93  ? 44.404 -81.994  18.247  1.00 66.60  ? 91  ILE A CG2 1 
ATOM 692  C CD1 . ILE A 1 93  ? 42.657 -84.553  18.866  1.00 72.42  ? 91  ILE A CD1 1 
ATOM 693  N N   . VAL A 1 94  ? 42.025 -82.870  14.067  1.00 66.61  ? 92  VAL A N   1 
ATOM 694  C CA  . VAL A 1 94  ? 41.633 -83.763  12.988  1.00 60.06  ? 92  VAL A CA  1 
ATOM 695  C C   . VAL A 1 94  ? 42.492 -83.420  11.773  1.00 64.23  ? 92  VAL A C   1 
ATOM 696  O O   . VAL A 1 94  ? 43.001 -82.299  11.654  1.00 66.40  ? 92  VAL A O   1 
ATOM 697  C CB  . VAL A 1 94  ? 40.128 -83.739  12.656  1.00 52.50  ? 92  VAL A CB  1 
ATOM 698  C CG1 . VAL A 1 94  ? 39.309 -84.340  13.788  1.00 50.83  ? 92  VAL A CG1 1 
ATOM 699  C CG2 . VAL A 1 94  ? 39.622 -82.342  12.300  1.00 48.90  ? 92  VAL A CG2 1 
ATOM 700  N N   . ASP A 1 95  ? 42.637 -84.418  10.893  1.00 60.28  ? 93  ASP A N   1 
ATOM 701  C CA  . ASP A 1 95  ? 43.567 -84.395  9.781   1.00 60.79  ? 93  ASP A CA  1 
ATOM 702  C C   . ASP A 1 95  ? 42.905 -83.742  8.571   1.00 69.76  ? 93  ASP A C   1 
ATOM 703  O O   . ASP A 1 95  ? 41.775 -84.093  8.238   1.00 75.27  ? 93  ASP A O   1 
ATOM 704  C CB  . ASP A 1 95  ? 43.955 -85.821  9.445   1.00 64.25  ? 93  ASP A CB  1 
ATOM 705  C CG  . ASP A 1 95  ? 45.252 -85.989  8.679   1.00 68.59  ? 93  ASP A CG  1 
ATOM 706  O OD1 . ASP A 1 95  ? 45.415 -85.335  7.636   1.00 59.40  ? 93  ASP A OD1 1 
ATOM 707  O OD2 . ASP A 1 95  ? 46.076 -86.788  9.141   1.00 88.39  ? 93  ASP A OD2 1 
ATOM 708  N N   . PRO A 1 96  ? 43.576 -82.808  7.850   1.00 75.07  ? 94  PRO A N   1 
ATOM 709  C CA  . PRO A 1 96  ? 42.948 -82.095  6.731   1.00 77.25  ? 94  PRO A CA  1 
ATOM 710  C C   . PRO A 1 96  ? 42.400 -83.048  5.674   1.00 75.42  ? 94  PRO A C   1 
ATOM 711  O O   . PRO A 1 96  ? 41.356 -82.783  5.070   1.00 83.26  ? 94  PRO A O   1 
ATOM 712  C CB  . PRO A 1 96  ? 44.051 -81.208  6.148   1.00 77.67  ? 94  PRO A CB  1 
ATOM 713  C CG  . PRO A 1 96  ? 45.101 -81.143  7.241   1.00 78.79  ? 94  PRO A CG  1 
ATOM 714  C CD  . PRO A 1 96  ? 44.977 -82.412  8.051   1.00 74.22  ? 94  PRO A CD  1 
ATOM 715  N N   . ILE A 1 97  ? 43.153 -84.130  5.446   1.00 65.03  ? 95  ILE A N   1 
ATOM 716  C CA  . ILE A 1 97  ? 42.715 -85.236  4.617   1.00 65.51  ? 95  ILE A CA  1 
ATOM 717  C C   . ILE A 1 97  ? 41.998 -86.255  5.498   1.00 67.28  ? 95  ILE A C   1 
ATOM 718  O O   . ILE A 1 97  ? 42.629 -87.003  6.247   1.00 65.52  ? 95  ILE A O   1 
ATOM 719  C CB  . ILE A 1 97  ? 43.905 -85.848  3.861   1.00 64.72  ? 95  ILE A CB  1 
ATOM 720  C CG1 . ILE A 1 97  ? 44.427 -84.863  2.842   1.00 69.93  ? 95  ILE A CG1 1 
ATOM 721  C CG2 . ILE A 1 97  ? 43.555 -87.187  3.207   1.00 61.81  ? 95  ILE A CG2 1 
ATOM 722  C CD1 . ILE A 1 97  ? 45.552 -85.416  1.989   1.00 74.31  ? 95  ILE A CD1 1 
ATOM 723  N N   . GLN A 1 98  ? 40.669 -86.296  5.341   1.00 60.97  ? 96  GLN A N   1 
ATOM 724  C CA  . GLN A 1 98  ? 39.806 -87.097  6.178   1.00 58.84  ? 96  GLN A CA  1 
ATOM 725  C C   . GLN A 1 98  ? 38.560 -87.487  5.399   1.00 59.96  ? 96  GLN A C   1 
ATOM 726  O O   . GLN A 1 98  ? 38.067 -86.705  4.588   1.00 59.41  ? 96  GLN A O   1 
ATOM 727  C CB  . GLN A 1 98  ? 39.386 -86.257  7.381   1.00 61.59  ? 96  GLN A CB  1 
ATOM 728  C CG  . GLN A 1 98  ? 38.743 -84.927  7.006   1.00 64.23  ? 96  GLN A CG  1 
ATOM 729  C CD  . GLN A 1 98  ? 38.212 -84.187  8.214   1.00 70.28  ? 96  GLN A CD  1 
ATOM 730  O OE1 . GLN A 1 98  ? 38.985 -83.657  9.023   1.00 58.92  ? 96  GLN A OE1 1 
ATOM 731  N NE2 . GLN A 1 98  ? 36.887 -84.164  8.354   1.00 74.62  ? 96  GLN A NE2 1 
ATOM 732  N N   . GLY A 1 99  ? 38.030 -88.674  5.726   1.00 64.93  ? 97  GLY A N   1 
ATOM 733  C CA  . GLY A 1 99  ? 36.697 -89.070  5.310   1.00 63.94  ? 97  GLY A CA  1 
ATOM 734  C C   . GLY A 1 99  ? 35.600 -88.227  5.971   1.00 66.24  ? 97  GLY A C   1 
ATOM 735  O O   . GLY A 1 99  ? 35.825 -87.399  6.859   1.00 52.75  ? 97  GLY A O   1 
ATOM 736  N N   . GLY A 1 100 ? 34.381 -88.444  5.487   1.00 75.39  ? 98  GLY A N   1 
ATOM 737  C CA  . GLY A 1 100 ? 33.192 -87.929  6.142   1.00 79.83  ? 98  GLY A CA  1 
ATOM 738  C C   . GLY A 1 100 ? 32.840 -86.513  5.705   1.00 70.70  ? 98  GLY A C   1 
ATOM 739  O O   . GLY A 1 100 ? 32.016 -85.878  6.343   1.00 73.89  ? 98  GLY A O   1 
ATOM 740  N N   . ALA A 1 101 ? 33.454 -86.022  4.626   1.00 73.85  ? 99  ALA A N   1 
ATOM 741  C CA  . ALA A 1 101 ? 32.960 -84.830  3.951   1.00 73.62  ? 99  ALA A CA  1 
ATOM 742  C C   . ALA A 1 101 ? 33.170 -83.573  4.787   1.00 72.33  ? 99  ALA A C   1 
ATOM 743  O O   . ALA A 1 101 ? 32.593 -82.526  4.489   1.00 76.15  ? 99  ALA A O   1 
ATOM 744  C CB  . ALA A 1 101 ? 31.496 -85.006  3.612   1.00 73.65  ? 99  ALA A CB  1 
ATOM 745  N N   . GLY A 1 102 ? 33.986 -83.683  5.838   1.00 75.82  ? 100 GLY A N   1 
ATOM 746  C CA  . GLY A 1 102 ? 34.274 -82.543  6.687   1.00 82.95  ? 100 GLY A CA  1 
ATOM 747  C C   . GLY A 1 102 ? 33.350 -82.485  7.894   1.00 81.31  ? 100 GLY A C   1 
ATOM 748  O O   . GLY A 1 102 ? 33.161 -81.414  8.456   1.00 93.89  ? 100 GLY A O   1 
ATOM 749  N N   . THR A 1 103 ? 32.787 -83.635  8.278   1.00 82.47  ? 101 THR A N   1 
ATOM 750  C CA  . THR A 1 103 ? 31.977 -83.731  9.482   1.00 84.21  ? 101 THR A CA  1 
ATOM 751  C C   . THR A 1 103 ? 32.919 -83.736  10.679  1.00 81.01  ? 101 THR A C   1 
ATOM 752  O O   . THR A 1 103 ? 32.669 -83.059  11.676  1.00 84.93  ? 101 THR A O   1 
ATOM 753  C CB  . THR A 1 103 ? 31.083 -84.973  9.444   1.00 91.53  ? 101 THR A CB  1 
ATOM 754  O OG1 . THR A 1 103 ? 29.873 -84.578  8.801   1.00 88.97  ? 101 THR A OG1 1 
ATOM 755  C CG2 . THR A 1 103 ? 30.706 -85.480  10.823  1.00 99.99  ? 101 THR A CG2 1 
ATOM 756  N N   . SER A 1 104 ? 34.024 -84.474  10.559  1.00 75.10  ? 102 SER A N   1 
ATOM 757  C CA  . SER A 1 104 ? 34.971 -84.549  11.654  1.00 64.85  ? 102 SER A CA  1 
ATOM 758  C C   . SER A 1 104 ? 35.625 -83.194  11.921  1.00 58.86  ? 102 SER A C   1 
ATOM 759  O O   . SER A 1 104 ? 36.138 -83.010  13.017  1.00 67.05  ? 102 SER A O   1 
ATOM 760  C CB  . SER A 1 104 ? 35.967 -85.636  11.419  1.00 61.45  ? 102 SER A CB  1 
ATOM 761  O OG  . SER A 1 104 ? 35.276 -86.864  11.251  1.00 63.82  ? 102 SER A OG  1 
ATOM 762  N N   . ILE A 1 105 ? 35.599 -82.245  10.968  1.00 56.70  ? 103 ILE A N   1 
ATOM 763  C CA  . ILE A 1 105 ? 36.073 -80.892  11.250  1.00 63.56  ? 103 ILE A CA  1 
ATOM 764  C C   . ILE A 1 105 ? 34.992 -80.149  12.033  1.00 67.47  ? 103 ILE A C   1 
ATOM 765  O O   . ILE A 1 105 ? 35.249 -79.608  13.106  1.00 70.42  ? 103 ILE A O   1 
ATOM 766  C CB  . ILE A 1 105 ? 36.478 -80.107  9.985   1.00 61.46  ? 103 ILE A CB  1 
ATOM 767  C CG1 . ILE A 1 105 ? 37.663 -80.736  9.285   1.00 63.49  ? 103 ILE A CG1 1 
ATOM 768  C CG2 . ILE A 1 105 ? 36.783 -78.647  10.323  1.00 53.83  ? 103 ILE A CG2 1 
ATOM 769  C CD1 . ILE A 1 105 ? 37.947 -80.136  7.925   1.00 65.31  ? 103 ILE A CD1 1 
ATOM 770  N N   . ASN A 1 106 ? 33.784 -80.120  11.471  1.00 68.53  ? 104 ASN A N   1 
ATOM 771  C CA  . ASN A 1 106 ? 32.632 -79.526  12.126  1.00 65.93  ? 104 ASN A CA  1 
ATOM 772  C C   . ASN A 1 106 ? 32.563 -79.991  13.582  1.00 66.03  ? 104 ASN A C   1 
ATOM 773  O O   . ASN A 1 106 ? 32.419 -79.170  14.476  1.00 69.22  ? 104 ASN A O   1 
ATOM 774  C CB  . ASN A 1 106 ? 31.360 -79.850  11.351  1.00 63.55  ? 104 ASN A CB  1 
ATOM 775  C CG  . ASN A 1 106 ? 30.191 -78.988  11.749  1.00 63.84  ? 104 ASN A CG  1 
ATOM 776  O OD1 . ASN A 1 106 ? 30.257 -77.758  11.640  1.00 61.06  ? 104 ASN A OD1 1 
ATOM 777  N ND2 . ASN A 1 106 ? 29.105 -79.615  12.171  1.00 65.89  ? 104 ASN A ND2 1 
ATOM 778  N N   . MET A 1 107 ? 32.702 -81.299  13.824  1.00 68.04  ? 105 MET A N   1 
ATOM 779  C CA  . MET A 1 107 ? 32.556 -81.841  15.169  1.00 73.63  ? 105 MET A CA  1 
ATOM 780  C C   . MET A 1 107 ? 33.728 -81.446  16.077  1.00 73.70  ? 105 MET A C   1 
ATOM 781  O O   . MET A 1 107 ? 33.593 -81.447  17.297  1.00 65.08  ? 105 MET A O   1 
ATOM 782  C CB  . MET A 1 107 ? 32.413 -83.370  15.139  1.00 75.08  ? 105 MET A CB  1 
ATOM 783  C CG  . MET A 1 107 ? 31.080 -83.843  14.607  1.00 74.93  ? 105 MET A CG  1 
ATOM 784  S SD  . MET A 1 107 ? 29.703 -82.911  15.306  1.00 79.43  ? 105 MET A SD  1 
ATOM 785  C CE  . MET A 1 107 ? 29.891 -83.142  17.079  1.00 85.56  ? 105 MET A CE  1 
ATOM 786  N N   . ASN A 1 108 ? 34.903 -81.183  15.499  1.00 70.61  ? 106 ASN A N   1 
ATOM 787  C CA  . ASN A 1 108 ? 36.060 -80.805  16.289  1.00 59.87  ? 106 ASN A CA  1 
ATOM 788  C C   . ASN A 1 108 ? 35.848 -79.378  16.769  1.00 55.34  ? 106 ASN A C   1 
ATOM 789  O O   . ASN A 1 108 ? 36.331 -79.025  17.829  1.00 65.78  ? 106 ASN A O   1 
ATOM 790  C CB  . ASN A 1 108 ? 37.360 -80.981  15.509  1.00 63.70  ? 106 ASN A CB  1 
ATOM 791  C CG  . ASN A 1 108 ? 38.606 -80.965  16.370  1.00 66.21  ? 106 ASN A CG  1 
ATOM 792  O OD1 . ASN A 1 108 ? 39.716 -81.108  15.848  1.00 61.92  ? 106 ASN A OD1 1 
ATOM 793  N ND2 . ASN A 1 108 ? 38.474 -80.786  17.675  1.00 65.80  ? 106 ASN A ND2 1 
ATOM 794  N N   . ALA A 1 109 ? 35.163 -78.552  15.979  1.00 53.67  ? 107 ALA A N   1 
ATOM 795  C CA  . ALA A 1 109 ? 34.778 -77.220  16.428  1.00 60.27  ? 107 ALA A CA  1 
ATOM 796  C C   . ALA A 1 109 ? 33.670 -77.296  17.478  1.00 66.53  ? 107 ALA A C   1 
ATOM 797  O O   . ALA A 1 109 ? 33.666 -76.520  18.428  1.00 78.13  ? 107 ALA A O   1 
ATOM 798  C CB  . ALA A 1 109 ? 34.345 -76.369  15.260  1.00 62.26  ? 107 ALA A CB  1 
ATOM 799  N N   . ASN A 1 110 ? 32.710 -78.204  17.276  1.00 65.91  ? 108 ASN A N   1 
ATOM 800  C CA  . ASN A 1 110 ? 31.561 -78.322  18.156  1.00 63.60  ? 108 ASN A CA  1 
ATOM 801  C C   . ASN A 1 110 ? 31.993 -78.790  19.547  1.00 69.07  ? 108 ASN A C   1 
ATOM 802  O O   . ASN A 1 110 ? 31.618 -78.182  20.544  1.00 69.90  ? 108 ASN A O   1 
ATOM 803  C CB  . ASN A 1 110 ? 30.518 -79.256  17.555  1.00 65.27  ? 108 ASN A CB  1 
ATOM 804  C CG  . ASN A 1 110 ? 29.791 -78.648  16.381  1.00 66.97  ? 108 ASN A CG  1 
ATOM 805  O OD1 . ASN A 1 110 ? 29.652 -77.421  16.292  1.00 62.23  ? 108 ASN A OD1 1 
ATOM 806  N ND2 . ASN A 1 110 ? 29.285 -79.493  15.491  1.00 71.04  ? 108 ASN A ND2 1 
ATOM 807  N N   . GLU A 1 111 ? 32.805 -79.855  19.599  1.00 77.82  ? 109 GLU A N   1 
ATOM 808  C CA  . GLU A 1 111 ? 33.254 -80.461  20.847  1.00 77.13  ? 109 GLU A CA  1 
ATOM 809  C C   . GLU A 1 111 ? 34.224 -79.554  21.619  1.00 77.94  ? 109 GLU A C   1 
ATOM 810  O O   . GLU A 1 111 ? 34.267 -79.612  22.838  1.00 83.74  ? 109 GLU A O   1 
ATOM 811  C CB  . GLU A 1 111 ? 33.868 -81.836  20.581  1.00 72.30  ? 109 GLU A CB  1 
ATOM 812  C CG  . GLU A 1 111 ? 32.833 -82.869  20.148  1.00 79.48  ? 109 GLU A CG  1 
ATOM 813  C CD  . GLU A 1 111 ? 33.398 -84.232  19.779  1.00 88.58  ? 109 GLU A CD  1 
ATOM 814  O OE1 . GLU A 1 111 ? 34.636 -84.331  19.693  1.00 83.87  ? 109 GLU A OE1 1 
ATOM 815  O OE2 . GLU A 1 111 ? 32.621 -85.198  19.593  1.00 97.41  ? 109 GLU A OE2 1 
ATOM 816  N N   . VAL A 1 112 ? 35.005 -78.709  20.940  1.00 74.98  ? 110 VAL A N   1 
ATOM 817  C CA  . VAL A 1 112 ? 35.905 -77.804  21.637  1.00 72.50  ? 110 VAL A CA  1 
ATOM 818  C C   . VAL A 1 112 ? 35.132 -76.578  22.127  1.00 74.70  ? 110 VAL A C   1 
ATOM 819  O O   . VAL A 1 112 ? 35.270 -76.194  23.284  1.00 81.46  ? 110 VAL A O   1 
ATOM 820  C CB  . VAL A 1 112 ? 37.122 -77.421  20.778  1.00 71.30  ? 110 VAL A CB  1 
ATOM 821  C CG1 . VAL A 1 112 ? 37.771 -76.114  21.229  1.00 83.94  ? 110 VAL A CG1 1 
ATOM 822  C CG2 . VAL A 1 112 ? 38.144 -78.544  20.757  1.00 66.23  ? 110 VAL A CG2 1 
ATOM 823  N N   . ILE A 1 113 ? 34.319 -75.958  21.268  1.00 72.85  ? 111 ILE A N   1 
ATOM 824  C CA  . ILE A 1 113 ? 33.575 -74.782  21.685  1.00 82.42  ? 111 ILE A CA  1 
ATOM 825  C C   . ILE A 1 113 ? 32.678 -75.130  22.879  1.00 86.94  ? 111 ILE A C   1 
ATOM 826  O O   . ILE A 1 113 ? 32.512 -74.306  23.778  1.00 101.31 ? 111 ILE A O   1 
ATOM 827  C CB  . ILE A 1 113 ? 32.797 -74.154  20.508  1.00 88.89  ? 111 ILE A CB  1 
ATOM 828  C CG1 . ILE A 1 113 ? 33.747 -73.502  19.506  1.00 84.05  ? 111 ILE A CG1 1 
ATOM 829  C CG2 . ILE A 1 113 ? 31.744 -73.145  20.985  1.00 91.54  ? 111 ILE A CG2 1 
ATOM 830  C CD1 . ILE A 1 113 ? 33.089 -73.121  18.190  1.00 85.77  ? 111 ILE A CD1 1 
ATOM 831  N N   . ALA A 1 114 ? 32.109 -76.343  22.901  1.00 87.21  ? 112 ALA A N   1 
ATOM 832  C CA  . ALA A 1 114 ? 31.230 -76.763  23.988  1.00 87.71  ? 112 ALA A CA  1 
ATOM 833  C C   . ALA A 1 114 ? 31.997 -76.866  25.304  1.00 85.64  ? 112 ALA A C   1 
ATOM 834  O O   . ALA A 1 114 ? 31.641 -76.210  26.276  1.00 82.67  ? 112 ALA A O   1 
ATOM 835  C CB  . ALA A 1 114 ? 30.578 -78.083  23.653  1.00 93.02  ? 112 ALA A CB  1 
ATOM 836  N N   . ASN A 1 115 ? 33.060 -77.679  25.322  1.00 82.54  ? 113 ASN A N   1 
ATOM 837  C CA  . ASN A 1 115 ? 33.828 -77.939  26.531  1.00 70.02  ? 113 ASN A CA  1 
ATOM 838  C C   . ASN A 1 115 ? 34.465 -76.672  27.089  1.00 66.16  ? 113 ASN A C   1 
ATOM 839  O O   . ASN A 1 115 ? 34.846 -76.643  28.255  1.00 83.16  ? 113 ASN A O   1 
ATOM 840  C CB  . ASN A 1 115 ? 34.916 -78.981  26.315  1.00 66.45  ? 113 ASN A CB  1 
ATOM 841  C CG  . ASN A 1 115 ? 34.369 -80.386  26.388  1.00 76.09  ? 113 ASN A CG  1 
ATOM 842  O OD1 . ASN A 1 115 ? 33.496 -80.659  27.214  1.00 84.34  ? 113 ASN A OD1 1 
ATOM 843  N ND2 . ASN A 1 115 ? 34.856 -81.291  25.553  1.00 85.08  ? 113 ASN A ND2 1 
ATOM 844  N N   . ARG A 1 116 ? 34.614 -75.643  26.261  1.00 63.25  ? 114 ARG A N   1 
ATOM 845  C CA  . ARG A 1 116 ? 35.227 -74.413  26.714  1.00 66.12  ? 114 ARG A CA  1 
ATOM 846  C C   . ARG A 1 116 ? 34.143 -73.395  27.047  1.00 69.62  ? 114 ARG A C   1 
ATOM 847  O O   . ARG A 1 116 ? 34.403 -72.468  27.802  1.00 85.16  ? 114 ARG A O   1 
ATOM 848  C CB  . ARG A 1 116 ? 36.213 -73.903  25.663  1.00 75.88  ? 114 ARG A CB  1 
ATOM 849  C CG  . ARG A 1 116 ? 36.770 -72.519  25.936  1.00 78.78  ? 114 ARG A CG  1 
ATOM 850  C CD  . ARG A 1 116 ? 37.436 -72.443  27.282  1.00 80.94  ? 114 ARG A CD  1 
ATOM 851  N NE  . ARG A 1 116 ? 37.688 -71.031  27.593  1.00 86.40  ? 114 ARG A NE  1 
ATOM 852  C CZ  . ARG A 1 116 ? 38.033 -70.580  28.781  1.00 83.83  ? 114 ARG A CZ  1 
ATOM 853  N NH1 . ARG A 1 116 ? 38.062 -71.391  29.823  1.00 87.71  ? 114 ARG A NH1 1 
ATOM 854  N NH2 . ARG A 1 116 ? 38.336 -69.311  28.921  1.00 82.84  ? 114 ARG A NH2 1 
ATOM 855  N N   . ALA A 1 117 ? 32.943 -73.554  26.482  1.00 73.95  ? 115 ALA A N   1 
ATOM 856  C CA  . ALA A 1 117 ? 31.788 -72.793  26.942  1.00 79.78  ? 115 ALA A CA  1 
ATOM 857  C C   . ALA A 1 117 ? 31.375 -73.307  28.325  1.00 90.72  ? 115 ALA A C   1 
ATOM 858  O O   . ALA A 1 117 ? 30.930 -72.520  29.157  1.00 109.82 ? 115 ALA A O   1 
ATOM 859  C CB  . ALA A 1 117 ? 30.646 -72.870  25.940  1.00 76.00  ? 115 ALA A CB  1 
ATOM 860  N N   . LEU A 1 118 ? 31.547 -74.622  28.561  1.00 89.58  ? 116 LEU A N   1 
ATOM 861  C CA  . LEU A 1 118 ? 31.363 -75.233  29.872  1.00 83.89  ? 116 LEU A CA  1 
ATOM 862  C C   . LEU A 1 118 ? 32.260 -74.532  30.891  1.00 85.21  ? 116 LEU A C   1 
ATOM 863  O O   . LEU A 1 118 ? 31.749 -73.837  31.764  1.00 80.31  ? 116 LEU A O   1 
ATOM 864  C CB  . LEU A 1 118 ? 31.626 -76.741  29.854  1.00 78.63  ? 116 LEU A CB  1 
ATOM 865  C CG  . LEU A 1 118 ? 30.582 -77.615  29.147  1.00 75.47  ? 116 LEU A CG  1 
ATOM 866  C CD1 . LEU A 1 118 ? 31.038 -79.061  29.147  1.00 66.48  ? 116 LEU A CD1 1 
ATOM 867  C CD2 . LEU A 1 118 ? 29.190 -77.494  29.756  1.00 80.14  ? 116 LEU A CD2 1 
ATOM 868  N N   . GLU A 1 119 ? 33.586 -74.688  30.765  1.00 80.83  ? 117 GLU A N   1 
ATOM 869  C CA  . GLU A 1 119 ? 34.532 -74.000  31.634  1.00 77.81  ? 117 GLU A CA  1 
ATOM 870  C C   . GLU A 1 119 ? 34.040 -72.585  31.972  1.00 77.93  ? 117 GLU A C   1 
ATOM 871  O O   . GLU A 1 119 ? 34.085 -72.180  33.138  1.00 78.95  ? 117 GLU A O   1 
ATOM 872  C CB  . GLU A 1 119 ? 35.934 -73.968  31.018  1.00 81.27  ? 117 GLU A CB  1 
ATOM 873  C CG  . GLU A 1 119 ? 36.790 -75.210  31.280  1.00 88.79  ? 117 GLU A CG  1 
ATOM 874  C CD  . GLU A 1 119 ? 38.298 -74.938  31.228  1.00 95.87  ? 117 GLU A CD  1 
ATOM 875  O OE1 . GLU A 1 119 ? 38.682 -74.002  30.510  1.00 98.12  ? 117 GLU A OE1 1 
ATOM 876  O OE2 . GLU A 1 119 ? 39.109 -75.586  31.927  1.00 92.47  ? 117 GLU A OE2 1 
ATOM 877  N N   . ILE A 1 120 ? 33.532 -71.856  30.967  1.00 87.63  ? 118 ILE A N   1 
ATOM 878  C CA  . ILE A 1 120 ? 33.220 -70.437  31.106  1.00 97.15  ? 118 ILE A CA  1 
ATOM 879  C C   . ILE A 1 120 ? 31.909 -70.249  31.871  1.00 92.87  ? 118 ILE A C   1 
ATOM 880  O O   . ILE A 1 120 ? 31.665 -69.159  32.384  1.00 85.06  ? 118 ILE A O   1 
ATOM 881  C CB  . ILE A 1 120 ? 33.213 -69.726  29.728  1.00 93.40  ? 118 ILE A CB  1 
ATOM 882  C CG1 . ILE A 1 120 ? 34.647 -69.574  29.177  1.00 86.48  ? 118 ILE A CG1 1 
ATOM 883  C CG2 . ILE A 1 120 ? 32.481 -68.379  29.781  1.00 88.87  ? 118 ILE A CG2 1 
ATOM 884  C CD1 . ILE A 1 120 ? 34.739 -69.091  27.739  1.00 83.03  ? 118 ILE A CD1 1 
ATOM 885  N N   . MET A 1 121 ? 31.063 -71.289  31.922  1.00 94.71  ? 119 MET A N   1 
ATOM 886  C CA  . MET A 1 121 ? 29.887 -71.258  32.784  1.00 99.57  ? 119 MET A CA  1 
ATOM 887  C C   . MET A 1 121 ? 30.160 -72.104  34.028  1.00 93.31  ? 119 MET A C   1 
ATOM 888  O O   . MET A 1 121 ? 29.233 -72.677  34.612  1.00 88.57  ? 119 MET A O   1 
ATOM 889  C CB  . MET A 1 121 ? 28.604 -71.706  32.063  1.00 98.96  ? 119 MET A CB  1 
ATOM 890  C CG  . MET A 1 121 ? 28.634 -73.128  31.532  1.00 101.49 ? 119 MET A CG  1 
ATOM 891  S SD  . MET A 1 121 ? 27.049 -73.717  30.910  1.00 99.22  ? 119 MET A SD  1 
ATOM 892  C CE  . MET A 1 121 ? 26.636 -72.491  29.662  1.00 94.66  ? 119 MET A CE  1 
ATOM 893  N N   . GLY A 1 122 ? 31.443 -72.205  34.402  1.00 87.53  ? 120 GLY A N   1 
ATOM 894  C CA  . GLY A 1 122 ? 31.820 -72.760  35.691  1.00 83.91  ? 120 GLY A CA  1 
ATOM 895  C C   . GLY A 1 122 ? 31.796 -74.286  35.735  1.00 89.74  ? 120 GLY A C   1 
ATOM 896  O O   . GLY A 1 122 ? 32.343 -74.846  36.677  1.00 105.55 ? 120 GLY A O   1 
ATOM 897  N N   . LYS A 1 123 ? 31.195 -74.951  34.731  1.00 92.76  ? 121 LYS A N   1 
ATOM 898  C CA  . LYS A 1 123 ? 31.092 -76.408  34.699  1.00 96.77  ? 121 LYS A CA  1 
ATOM 899  C C   . LYS A 1 123 ? 32.453 -77.032  34.386  1.00 101.27 ? 121 LYS A C   1 
ATOM 900  O O   . LYS A 1 123 ? 33.465 -76.335  34.269  1.00 111.59 ? 121 LYS A O   1 
ATOM 901  C CB  . LYS A 1 123 ? 30.082 -76.915  33.661  1.00 97.45  ? 121 LYS A CB  1 
ATOM 902  C CG  . LYS A 1 123 ? 28.751 -76.199  33.657  1.00 104.57 ? 121 LYS A CG  1 
ATOM 903  C CD  . LYS A 1 123 ? 27.991 -76.427  34.950  1.00 111.60 ? 121 LYS A CD  1 
ATOM 904  C CE  . LYS A 1 123 ? 26.666 -75.763  34.935  1.00 119.62 ? 121 LYS A CE  1 
ATOM 905  N NZ  . LYS A 1 123 ? 25.882 -76.210  36.089  1.00 132.22 ? 121 LYS A NZ  1 
ATOM 906  N N   . LYS A 1 124 ? 32.462 -78.362  34.252  1.00 99.78  ? 122 LYS A N   1 
ATOM 907  C CA  . LYS A 1 124 ? 33.661 -79.077  33.855  1.00 101.60 ? 122 LYS A CA  1 
ATOM 908  C C   . LYS A 1 124 ? 33.451 -79.632  32.456  1.00 101.59 ? 122 LYS A C   1 
ATOM 909  O O   . LYS A 1 124 ? 32.319 -79.796  32.013  1.00 97.24  ? 122 LYS A O   1 
ATOM 910  C CB  . LYS A 1 124 ? 33.987 -80.185  34.858  1.00 108.20 ? 122 LYS A CB  1 
ATOM 911  C CG  . LYS A 1 124 ? 34.599 -79.639  36.130  1.00 118.67 ? 122 LYS A CG  1 
ATOM 912  C CD  . LYS A 1 124 ? 34.689 -80.609  37.291  1.00 122.21 ? 122 LYS A CD  1 
ATOM 913  C CE  . LYS A 1 124 ? 34.973 -79.837  38.544  1.00 129.47 ? 122 LYS A CE  1 
ATOM 914  N NZ  . LYS A 1 124 ? 34.929 -80.722  39.707  1.00 151.27 ? 122 LYS A NZ  1 
ATOM 915  N N   . LYS A 1 125 ? 34.564 -79.910  31.777  1.00 100.71 ? 123 LYS A N   1 
ATOM 916  C CA  . LYS A 1 125 ? 34.525 -80.474  30.440  1.00 94.94  ? 123 LYS A CA  1 
ATOM 917  C C   . LYS A 1 125 ? 33.850 -81.838  30.508  1.00 79.47  ? 123 LYS A C   1 
ATOM 918  O O   . LYS A 1 125 ? 33.971 -82.539  31.497  1.00 79.19  ? 123 LYS A O   1 
ATOM 919  C CB  . LYS A 1 125 ? 35.953 -80.627  29.910  1.00 101.76 ? 123 LYS A CB  1 
ATOM 920  C CG  . LYS A 1 125 ? 36.784 -79.354  29.904  1.00 103.10 ? 123 LYS A CG  1 
ATOM 921  C CD  . LYS A 1 125 ? 38.277 -79.636  29.906  1.00 104.15 ? 123 LYS A CD  1 
ATOM 922  C CE  . LYS A 1 125 ? 39.051 -78.381  30.095  1.00 114.52 ? 123 LYS A CE  1 
ATOM 923  N NZ  . LYS A 1 125 ? 40.444 -78.697  30.413  1.00 121.52 ? 123 LYS A NZ  1 
ATOM 924  N N   . GLY A 1 126 ? 33.122 -82.199  29.462  1.00 72.65  ? 124 GLY A N   1 
ATOM 925  C CA  . GLY A 1 126 ? 32.445 -83.475  29.429  1.00 75.75  ? 124 GLY A CA  1 
ATOM 926  C C   . GLY A 1 126 ? 31.042 -83.367  29.996  1.00 74.71  ? 124 GLY A C   1 
ATOM 927  O O   . GLY A 1 126 ? 30.285 -84.316  29.867  1.00 90.17  ? 124 GLY A O   1 
ATOM 928  N N   . ASP A 1 127 ? 30.707 -82.251  30.642  1.00 76.04  ? 125 ASP A N   1 
ATOM 929  C CA  . ASP A 1 127 ? 29.369 -82.092  31.192  1.00 92.79  ? 125 ASP A CA  1 
ATOM 930  C C   . ASP A 1 127 ? 28.461 -81.626  30.061  1.00 90.39  ? 125 ASP A C   1 
ATOM 931  O O   . ASP A 1 127 ? 27.979 -80.495  30.082  1.00 93.16  ? 125 ASP A O   1 
ATOM 932  C CB  . ASP A 1 127 ? 29.343 -81.133  32.377  1.00 100.33 ? 125 ASP A CB  1 
ATOM 933  C CG  . ASP A 1 127 ? 28.271 -81.394  33.422  1.00 101.05 ? 125 ASP A CG  1 
ATOM 934  O OD1 . ASP A 1 127 ? 27.088 -81.593  33.038  1.00 112.34 ? 125 ASP A OD1 1 
ATOM 935  O OD2 . ASP A 1 127 ? 28.648 -81.414  34.607  1.00 98.52  ? 125 ASP A OD2 1 
ATOM 936  N N   . TYR A 1 128 ? 28.237 -82.509  29.086  1.00 90.77  ? 126 TYR A N   1 
ATOM 937  C CA  . TYR A 1 128 ? 27.538 -82.105  27.880  1.00 106.22 ? 126 TYR A CA  1 
ATOM 938  C C   . TYR A 1 128 ? 26.081 -81.808  28.190  1.00 115.98 ? 126 TYR A C   1 
ATOM 939  O O   . TYR A 1 128 ? 25.473 -80.993  27.491  1.00 142.07 ? 126 TYR A O   1 
ATOM 940  C CB  . TYR A 1 128 ? 27.745 -83.157  26.789  1.00 98.86  ? 126 TYR A CB  1 
ATOM 941  C CG  . TYR A 1 128 ? 29.180 -83.194  26.290  1.00 100.06 ? 126 TYR A CG  1 
ATOM 942  C CD1 . TYR A 1 128 ? 29.901 -82.022  26.088  1.00 98.89  ? 126 TYR A CD1 1 
ATOM 943  C CD2 . TYR A 1 128 ? 29.830 -84.399  26.064  1.00 100.39 ? 126 TYR A CD2 1 
ATOM 944  C CE1 . TYR A 1 128 ? 31.213 -82.043  25.643  1.00 90.41  ? 126 TYR A CE1 1 
ATOM 945  C CE2 . TYR A 1 128 ? 31.146 -84.435  25.636  1.00 91.48  ? 126 TYR A CE2 1 
ATOM 946  C CZ  . TYR A 1 128 ? 31.840 -83.256  25.425  1.00 87.58  ? 126 TYR A CZ  1 
ATOM 947  O OH  . TYR A 1 128 ? 33.133 -83.314  25.005  1.00 74.76  ? 126 TYR A OH  1 
ATOM 948  N N   . PHE A 1 129 ? 25.518 -82.444  29.218  1.00 106.03 ? 127 PHE A N   1 
ATOM 949  C CA  . PHE A 1 129 ? 24.128 -82.175  29.508  1.00 105.91 ? 127 PHE A CA  1 
ATOM 950  C C   . PHE A 1 129 ? 23.856 -80.685  29.255  1.00 103.53 ? 127 PHE A C   1 
ATOM 951  O O   . PHE A 1 129 ? 22.859 -80.321  28.623  1.00 103.61 ? 127 PHE A O   1 
ATOM 952  C CB  . PHE A 1 129 ? 23.721 -82.580  30.931  1.00 106.42 ? 127 PHE A CB  1 
ATOM 953  C CG  . PHE A 1 129 ? 22.379 -81.953  31.291  1.00 100.24 ? 127 PHE A CG  1 
ATOM 954  C CD1 . PHE A 1 129 ? 21.179 -82.518  30.865  1.00 93.97  ? 127 PHE A CD1 1 
ATOM 955  C CD2 . PHE A 1 129 ? 22.332 -80.746  31.986  1.00 92.80  ? 127 PHE A CD2 1 
ATOM 956  C CE1 . PHE A 1 129 ? 19.974 -81.897  31.151  1.00 96.00  ? 127 PHE A CE1 1 
ATOM 957  C CE2 . PHE A 1 129 ? 21.129 -80.124  32.266  1.00 89.92  ? 127 PHE A CE2 1 
ATOM 958  C CZ  . PHE A 1 129 ? 19.952 -80.706  31.850  1.00 92.30  ? 127 PHE A CZ  1 
ATOM 959  N N   . HIS A 1 130 ? 24.745 -79.825  29.762  1.00 91.92  ? 128 HIS A N   1 
ATOM 960  C CA  . HIS A 1 130 ? 24.452 -78.404  29.822  1.00 90.93  ? 128 HIS A CA  1 
ATOM 961  C C   . HIS A 1 130 ? 24.690 -77.763  28.459  1.00 99.03  ? 128 HIS A C   1 
ATOM 962  O O   . HIS A 1 130 ? 23.792 -77.130  27.915  1.00 103.48 ? 128 HIS A O   1 
ATOM 963  C CB  . HIS A 1 130 ? 25.256 -77.713  30.930  1.00 102.70 ? 128 HIS A CB  1 
ATOM 964  C CG  . HIS A 1 130 ? 25.020 -78.209  32.327  1.00 110.22 ? 128 HIS A CG  1 
ATOM 965  N ND1 . HIS A 1 130 ? 23.828 -78.122  33.022  1.00 97.48  ? 128 HIS A ND1 1 
ATOM 966  C CD2 . HIS A 1 130 ? 25.891 -78.785  33.172  1.00 113.38 ? 128 HIS A CD2 1 
ATOM 967  C CE1 . HIS A 1 130 ? 23.993 -78.630  34.238  1.00 101.16 ? 128 HIS A CE1 1 
ATOM 968  N NE2 . HIS A 1 130 ? 25.234 -79.048  34.349  1.00 103.10 ? 128 HIS A NE2 1 
ATOM 969  N N   . VAL A 1 131 ? 25.911 -77.920  27.928  1.00 108.06 ? 129 VAL A N   1 
ATOM 970  C CA  . VAL A 1 131 ? 26.286 -77.432  26.606  1.00 90.74  ? 129 VAL A CA  1 
ATOM 971  C C   . VAL A 1 131 ? 26.544 -78.633  25.696  1.00 81.99  ? 129 VAL A C   1 
ATOM 972  O O   . VAL A 1 131 ? 27.502 -79.376  25.905  1.00 74.86  ? 129 VAL A O   1 
ATOM 973  C CB  . VAL A 1 131 ? 27.536 -76.543  26.686  1.00 79.82  ? 129 VAL A CB  1 
ATOM 974  C CG1 . VAL A 1 131 ? 27.877 -75.949  25.327  1.00 79.63  ? 129 VAL A CG1 1 
ATOM 975  C CG2 . VAL A 1 131 ? 27.398 -75.459  27.748  1.00 79.99  ? 129 VAL A CG2 1 
ATOM 976  N N   . ARG A 1 132 ? 25.678 -78.817  24.695  1.00 74.78  ? 130 ARG A N   1 
ATOM 977  C CA  . ARG A 1 132 ? 25.681 -80.025  23.882  1.00 85.94  ? 130 ARG A CA  1 
ATOM 978  C C   . ARG A 1 132 ? 26.327 -79.756  22.525  1.00 83.95  ? 130 ARG A C   1 
ATOM 979  O O   . ARG A 1 132 ? 25.896 -78.849  21.813  1.00 79.97  ? 130 ARG A O   1 
ATOM 980  C CB  . ARG A 1 132 ? 24.259 -80.544  23.650  1.00 105.88 ? 130 ARG A CB  1 
ATOM 981  C CG  . ARG A 1 132 ? 23.658 -81.318  24.809  1.00 120.09 ? 130 ARG A CG  1 
ATOM 982  C CD  . ARG A 1 132 ? 22.233 -81.716  24.491  1.00 138.83 ? 130 ARG A CD  1 
ATOM 983  N NE  . ARG A 1 132 ? 21.477 -82.004  25.714  1.00 155.67 ? 130 ARG A NE  1 
ATOM 984  C CZ  . ARG A 1 132 ? 20.153 -82.096  25.767  1.00 159.23 ? 130 ARG A CZ  1 
ATOM 985  N NH1 . ARG A 1 132 ? 19.557 -82.265  26.938  1.00 148.04 ? 130 ARG A NH1 1 
ATOM 986  N NH2 . ARG A 1 132 ? 19.441 -81.989  24.651  1.00 152.34 ? 130 ARG A NH2 1 
ATOM 987  N N   . PRO A 1 133 ? 27.361 -80.537  22.119  1.00 82.83  ? 131 PRO A N   1 
ATOM 988  C CA  . PRO A 1 133 ? 27.973 -80.379  20.801  1.00 82.61  ? 131 PRO A CA  1 
ATOM 989  C C   . PRO A 1 133 ? 26.970 -80.351  19.649  1.00 80.45  ? 131 PRO A C   1 
ATOM 990  O O   . PRO A 1 133 ? 26.937 -79.397  18.875  1.00 83.86  ? 131 PRO A O   1 
ATOM 991  C CB  . PRO A 1 133 ? 28.922 -81.590  20.740  1.00 87.82  ? 131 PRO A CB  1 
ATOM 992  C CG  . PRO A 1 133 ? 29.330 -81.820  22.173  1.00 83.21  ? 131 PRO A CG  1 
ATOM 993  C CD  . PRO A 1 133 ? 28.041 -81.563  22.928  1.00 84.76  ? 131 PRO A CD  1 
ATOM 994  N N   . ASN A 1 134 ? 26.128 -81.383  19.548  1.00 73.89  ? 132 ASN A N   1 
ATOM 995  C CA  . ASN A 1 134 ? 25.181 -81.469  18.446  1.00 76.62  ? 132 ASN A CA  1 
ATOM 996  C C   . ASN A 1 134 ? 24.071 -80.430  18.591  1.00 76.99  ? 132 ASN A C   1 
ATOM 997  O O   . ASN A 1 134 ? 23.859 -79.608  17.703  1.00 73.84  ? 132 ASN A O   1 
ATOM 998  C CB  . ASN A 1 134 ? 24.592 -82.866  18.351  1.00 81.71  ? 132 ASN A CB  1 
ATOM 999  C CG  . ASN A 1 134 ? 25.638 -83.832  17.865  1.00 83.98  ? 132 ASN A CG  1 
ATOM 1000 O OD1 . ASN A 1 134 ? 26.304 -84.502  18.663  1.00 90.14  ? 132 ASN A OD1 1 
ATOM 1001 N ND2 . ASN A 1 134 ? 25.843 -83.850  16.562  1.00 86.20  ? 132 ASN A ND2 1 
ATOM 1002 N N   . SER A 1 135 ? 23.374 -80.469  19.730  1.00 79.12  ? 133 SER A N   1 
ATOM 1003 C CA  . SER A 1 135 ? 22.056 -79.871  19.853  1.00 82.63  ? 133 SER A CA  1 
ATOM 1004 C C   . SER A 1 135 ? 22.138 -78.354  20.024  1.00 83.70  ? 133 SER A C   1 
ATOM 1005 O O   . SER A 1 135 ? 21.202 -77.647  19.631  1.00 81.06  ? 133 SER A O   1 
ATOM 1006 C CB  . SER A 1 135 ? 21.279 -80.500  20.998  1.00 94.46  ? 133 SER A CB  1 
ATOM 1007 O OG  . SER A 1 135 ? 21.570 -81.883  21.191  1.00 99.69  ? 133 SER A OG  1 
ATOM 1008 N N   . ASP A 1 136 ? 23.252 -77.862  20.600  1.00 92.27  ? 134 ASP A N   1 
ATOM 1009 C CA  . ASP A 1 136 ? 23.375 -76.458  20.977  1.00 109.52 ? 134 ASP A CA  1 
ATOM 1010 C C   . ASP A 1 136 ? 24.415 -75.730  20.116  1.00 109.16 ? 134 ASP A C   1 
ATOM 1011 O O   . ASP A 1 136 ? 24.105 -74.710  19.485  1.00 118.13 ? 134 ASP A O   1 
ATOM 1012 C CB  . ASP A 1 136 ? 23.674 -76.288  22.461  1.00 112.61 ? 134 ASP A CB  1 
ATOM 1013 C CG  . ASP A 1 136 ? 22.868 -77.153  23.422  1.00 114.60 ? 134 ASP A CG  1 
ATOM 1014 O OD1 . ASP A 1 136 ? 21.660 -77.353  23.176  1.00 109.76 ? 134 ASP A OD1 1 
ATOM 1015 O OD2 . ASP A 1 136 ? 23.456 -77.597  24.429  1.00 106.54 ? 134 ASP A OD2 1 
ATOM 1016 N N   . VAL A 1 137 ? 25.657 -76.232  20.113  1.00 92.08  ? 135 VAL A N   1 
ATOM 1017 C CA  . VAL A 1 137 ? 26.726 -75.568  19.382  1.00 96.02  ? 135 VAL A CA  1 
ATOM 1018 C C   . VAL A 1 137 ? 26.341 -75.561  17.906  1.00 95.63  ? 135 VAL A C   1 
ATOM 1019 O O   . VAL A 1 137 ? 26.481 -74.528  17.246  1.00 106.37 ? 135 VAL A O   1 
ATOM 1020 C CB  . VAL A 1 137 ? 28.131 -76.179  19.572  1.00 94.99  ? 135 VAL A CB  1 
ATOM 1021 C CG1 . VAL A 1 137 ? 29.219 -75.355  18.874  1.00 88.17  ? 135 VAL A CG1 1 
ATOM 1022 C CG2 . VAL A 1 137 ? 28.475 -76.374  21.045  1.00 88.27  ? 135 VAL A CG2 1 
ATOM 1023 N N   . ASN A 1 138 ? 25.801 -76.706  17.449  1.00 85.46  ? 136 ASN A N   1 
ATOM 1024 C CA  . ASN A 1 138 ? 25.563 -76.988  16.041  1.00 85.91  ? 136 ASN A CA  1 
ATOM 1025 C C   . ASN A 1 138 ? 24.079 -76.871  15.665  1.00 87.63  ? 136 ASN A C   1 
ATOM 1026 O O   . ASN A 1 138 ? 23.647 -77.459  14.680  1.00 101.24 ? 136 ASN A O   1 
ATOM 1027 C CB  . ASN A 1 138 ? 26.103 -78.375  15.709  1.00 81.38  ? 136 ASN A CB  1 
ATOM 1028 C CG  . ASN A 1 138 ? 26.216 -78.610  14.225  1.00 79.58  ? 136 ASN A CG  1 
ATOM 1029 O OD1 . ASN A 1 138 ? 26.875 -77.831  13.531  1.00 80.19  ? 136 ASN A OD1 1 
ATOM 1030 N ND2 . ASN A 1 138 ? 25.578 -79.659  13.720  1.00 83.58  ? 136 ASN A ND2 1 
ATOM 1031 N N   . MET A 1 139 ? 23.302 -76.079  16.412  1.00 86.23  ? 137 MET A N   1 
ATOM 1032 C CA  . MET A 1 139 ? 21.870 -75.919  16.194  1.00 89.98  ? 137 MET A CA  1 
ATOM 1033 C C   . MET A 1 139 ? 21.612 -75.154  14.893  1.00 88.47  ? 137 MET A C   1 
ATOM 1034 O O   . MET A 1 139 ? 22.368 -74.244  14.568  1.00 104.90 ? 137 MET A O   1 
ATOM 1035 C CB  . MET A 1 139 ? 21.276 -75.138  17.372  1.00 102.05 ? 137 MET A CB  1 
ATOM 1036 C CG  . MET A 1 139 ? 19.764 -74.964  17.336  1.00 113.56 ? 137 MET A CG  1 
ATOM 1037 S SD  . MET A 1 139 ? 19.155 -73.848  18.619  1.00 104.52 ? 137 MET A SD  1 
ATOM 1038 C CE  . MET A 1 139 ? 19.548 -74.847  20.064  1.00 97.69  ? 137 MET A CE  1 
ATOM 1039 N N   . SER A 1 140 ? 20.545 -75.522  14.163  1.00 81.72  ? 138 SER A N   1 
ATOM 1040 C CA  . SER A 1 140 ? 20.151 -74.871  12.911  1.00 90.73  ? 138 SER A CA  1 
ATOM 1041 C C   . SER A 1 140 ? 21.171 -75.105  11.788  1.00 89.91  ? 138 SER A C   1 
ATOM 1042 O O   . SER A 1 140 ? 21.119 -74.454  10.739  1.00 89.80  ? 138 SER A O   1 
ATOM 1043 C CB  . SER A 1 140 ? 19.902 -73.390  13.100  1.00 90.32  ? 138 SER A CB  1 
ATOM 1044 O OG  . SER A 1 140 ? 18.910 -73.147  14.083  1.00 102.05 ? 138 SER A OG  1 
ATOM 1045 N N   . GLN A 1 141 ? 22.063 -76.080  11.997  1.00 80.03  ? 139 GLN A N   1 
ATOM 1046 C CA  . GLN A 1 141 ? 23.253 -76.234  11.185  1.00 75.47  ? 139 GLN A CA  1 
ATOM 1047 C C   . GLN A 1 141 ? 23.449 -77.699  10.813  1.00 79.28  ? 139 GLN A C   1 
ATOM 1048 O O   . GLN A 1 141 ? 23.119 -78.586  11.588  1.00 86.68  ? 139 GLN A O   1 
ATOM 1049 C CB  . GLN A 1 141 ? 24.499 -75.829  11.968  1.00 76.71  ? 139 GLN A CB  1 
ATOM 1050 C CG  . GLN A 1 141 ? 24.607 -74.345  12.302  1.00 78.81  ? 139 GLN A CG  1 
ATOM 1051 C CD  . GLN A 1 141 ? 25.674 -74.072  13.341  1.00 75.05  ? 139 GLN A CD  1 
ATOM 1052 O OE1 . GLN A 1 141 ? 26.876 -74.070  13.051  1.00 58.99  ? 139 GLN A OE1 1 
ATOM 1053 N NE2 . GLN A 1 141 ? 25.241 -73.854  14.575  1.00 75.18  ? 139 GLN A NE2 1 
ATOM 1054 N N   . SER A 1 142 ? 24.003 -77.930  9.619   1.00 83.94  ? 140 SER A N   1 
ATOM 1055 C CA  . SER A 1 142 ? 24.651 -79.186  9.282   1.00 78.83  ? 140 SER A CA  1 
ATOM 1056 C C   . SER A 1 142 ? 26.124 -78.923  8.990   1.00 78.76  ? 140 SER A C   1 
ATOM 1057 O O   . SER A 1 142 ? 26.524 -77.785  8.751   1.00 80.17  ? 140 SER A O   1 
ATOM 1058 C CB  . SER A 1 142 ? 23.990 -79.850  8.100   1.00 73.61  ? 140 SER A CB  1 
ATOM 1059 O OG  . SER A 1 142 ? 24.546 -81.139  7.877   1.00 71.95  ? 140 SER A OG  1 
ATOM 1060 N N   . THR A 1 143 ? 26.915 -80.000  8.990   1.00 73.18  ? 141 THR A N   1 
ATOM 1061 C CA  . THR A 1 143 ? 28.234 -79.997  8.381   1.00 67.71  ? 141 THR A CA  1 
ATOM 1062 C C   . THR A 1 143 ? 28.205 -79.221  7.066   1.00 69.88  ? 141 THR A C   1 
ATOM 1063 O O   . THR A 1 143 ? 29.113 -78.448  6.768   1.00 69.04  ? 141 THR A O   1 
ATOM 1064 C CB  . THR A 1 143 ? 28.650 -81.444  8.136   1.00 68.95  ? 141 THR A CB  1 
ATOM 1065 O OG1 . THR A 1 143 ? 28.528 -82.088  9.402   1.00 74.82  ? 141 THR A OG1 1 
ATOM 1066 C CG2 . THR A 1 143 ? 30.049 -81.548  7.556   1.00 70.49  ? 141 THR A CG2 1 
ATOM 1067 N N   . ASN A 1 144 ? 27.130 -79.428  6.296   1.00 71.50  ? 142 ASN A N   1 
ATOM 1068 C CA  . ASN A 1 144 ? 27.105 -79.118  4.877   1.00 64.51  ? 142 ASN A CA  1 
ATOM 1069 C C   . ASN A 1 144 ? 26.837 -77.638  4.629   1.00 60.27  ? 142 ASN A C   1 
ATOM 1070 O O   . ASN A 1 144 ? 26.791 -77.241  3.468   1.00 57.70  ? 142 ASN A O   1 
ATOM 1071 C CB  . ASN A 1 144 ? 26.108 -80.024  4.165   1.00 65.78  ? 142 ASN A CB  1 
ATOM 1072 C CG  . ASN A 1 144 ? 26.479 -81.488  4.312   1.00 73.90  ? 142 ASN A CG  1 
ATOM 1073 O OD1 . ASN A 1 144 ? 27.647 -81.840  4.535   1.00 70.24  ? 142 ASN A OD1 1 
ATOM 1074 N ND2 . ASN A 1 144 ? 25.508 -82.376  4.163   1.00 77.76  ? 142 ASN A ND2 1 
ATOM 1075 N N   . ASP A 1 145 ? 26.654 -76.840  5.696   1.00 67.51  ? 143 ASP A N   1 
ATOM 1076 C CA  . ASP A 1 145 ? 26.516 -75.389  5.567   1.00 77.44  ? 143 ASP A CA  1 
ATOM 1077 C C   . ASP A 1 145 ? 27.556 -74.672  6.425   1.00 66.86  ? 143 ASP A C   1 
ATOM 1078 O O   . ASP A 1 145 ? 28.101 -73.655  6.010   1.00 61.07  ? 143 ASP A O   1 
ATOM 1079 C CB  . ASP A 1 145 ? 25.091 -74.883  5.810   1.00 88.80  ? 143 ASP A CB  1 
ATOM 1080 C CG  . ASP A 1 145 ? 24.460 -75.148  7.173   1.00 88.38  ? 143 ASP A CG  1 
ATOM 1081 O OD1 . ASP A 1 145 ? 24.959 -76.044  7.880   1.00 77.51  ? 143 ASP A OD1 1 
ATOM 1082 O OD2 . ASP A 1 145 ? 23.478 -74.451  7.522   1.00 79.49  ? 143 ASP A OD2 1 
ATOM 1083 N N   . ALA A 1 146 ? 27.821 -75.187  7.624   1.00 66.09  ? 144 ALA A N   1 
ATOM 1084 C CA  . ALA A 1 146 ? 28.803 -74.569  8.498   1.00 76.65  ? 144 ALA A CA  1 
ATOM 1085 C C   . ALA A 1 146 ? 30.201 -74.667  7.894   1.00 71.79  ? 144 ALA A C   1 
ATOM 1086 O O   . ALA A 1 146 ? 30.906 -73.672  7.787   1.00 72.84  ? 144 ALA A O   1 
ATOM 1087 C CB  . ALA A 1 146 ? 28.770 -75.227  9.857   1.00 89.10  ? 144 ALA A CB  1 
ATOM 1088 N N   . PHE A 1 147 ? 30.597 -75.883  7.519   1.00 65.97  ? 145 PHE A N   1 
ATOM 1089 C CA  . PHE A 1 147 ? 31.945 -76.130  7.047   1.00 61.43  ? 145 PHE A CA  1 
ATOM 1090 C C   . PHE A 1 147 ? 32.237 -75.266  5.824   1.00 59.65  ? 145 PHE A C   1 
ATOM 1091 O O   . PHE A 1 147 ? 33.195 -74.499  5.839   1.00 53.70  ? 145 PHE A O   1 
ATOM 1092 C CB  . PHE A 1 147 ? 32.123 -77.626  6.781   1.00 63.37  ? 145 PHE A CB  1 
ATOM 1093 C CG  . PHE A 1 147 ? 33.431 -77.941  6.081   1.00 56.44  ? 145 PHE A CG  1 
ATOM 1094 C CD1 . PHE A 1 147 ? 34.587 -77.251  6.401   1.00 54.62  ? 145 PHE A CD1 1 
ATOM 1095 C CD2 . PHE A 1 147 ? 33.488 -78.906  5.097   1.00 55.49  ? 145 PHE A CD2 1 
ATOM 1096 C CE1 . PHE A 1 147 ? 35.774 -77.528  5.761   1.00 55.07  ? 145 PHE A CE1 1 
ATOM 1097 C CE2 . PHE A 1 147 ? 34.681 -79.182  4.465   1.00 59.64  ? 145 PHE A CE2 1 
ATOM 1098 C CZ  . PHE A 1 147 ? 35.818 -78.490  4.795   1.00 57.93  ? 145 PHE A CZ  1 
ATOM 1099 N N   . PRO A 1 148 ? 31.447 -75.348  4.726   1.00 65.57  ? 146 PRO A N   1 
ATOM 1100 C CA  . PRO A 1 148 ? 31.685 -74.491  3.564   1.00 70.29  ? 146 PRO A CA  1 
ATOM 1101 C C   . PRO A 1 148 ? 31.636 -72.989  3.863   1.00 70.73  ? 146 PRO A C   1 
ATOM 1102 O O   . PRO A 1 148 ? 32.476 -72.232  3.372   1.00 79.54  ? 146 PRO A O   1 
ATOM 1103 C CB  . PRO A 1 148 ? 30.632 -74.915  2.512   1.00 69.23  ? 146 PRO A CB  1 
ATOM 1104 C CG  . PRO A 1 148 ? 29.646 -75.786  3.253   1.00 73.47  ? 146 PRO A CG  1 
ATOM 1105 C CD  . PRO A 1 148 ? 30.338 -76.292  4.510   1.00 70.07  ? 146 PRO A CD  1 
ATOM 1106 N N   . THR A 1 149 ? 30.660 -72.553  4.667   1.00 65.26  ? 147 THR A N   1 
ATOM 1107 C CA  . THR A 1 149 ? 30.536 -71.139  4.984   1.00 63.31  ? 147 THR A CA  1 
ATOM 1108 C C   . THR A 1 149 ? 31.821 -70.656  5.660   1.00 60.61  ? 147 THR A C   1 
ATOM 1109 O O   . THR A 1 149 ? 32.299 -69.554  5.400   1.00 59.52  ? 147 THR A O   1 
ATOM 1110 C CB  . THR A 1 149 ? 29.304 -70.892  5.846   1.00 60.66  ? 147 THR A CB  1 
ATOM 1111 O OG1 . THR A 1 149 ? 28.226 -71.366  5.054   1.00 60.44  ? 147 THR A OG1 1 
ATOM 1112 C CG2 . THR A 1 149 ? 29.063 -69.419  6.116   1.00 65.23  ? 147 THR A CG2 1 
ATOM 1113 N N   . ALA A 1 150 ? 32.394 -71.505  6.511   1.00 58.52  ? 148 ALA A N   1 
ATOM 1114 C CA  . ALA A 1 150 ? 33.684 -71.214  7.108   1.00 60.32  ? 148 ALA A CA  1 
ATOM 1115 C C   . ALA A 1 150 ? 34.721 -71.067  6.000   1.00 56.00  ? 148 ALA A C   1 
ATOM 1116 O O   . ALA A 1 150 ? 35.361 -70.017  5.874   1.00 50.28  ? 148 ALA A O   1 
ATOM 1117 C CB  . ALA A 1 150 ? 34.057 -72.303  8.099   1.00 62.19  ? 148 ALA A CB  1 
ATOM 1118 N N   . VAL A 1 151 ? 34.810 -72.120  5.175   1.00 51.04  ? 149 VAL A N   1 
ATOM 1119 C CA  . VAL A 1 151 ? 35.786 -72.192  4.103   1.00 46.03  ? 149 VAL A CA  1 
ATOM 1120 C C   . VAL A 1 151 ? 35.711 -70.913  3.279   1.00 45.80  ? 149 VAL A C   1 
ATOM 1121 O O   . VAL A 1 151 ? 36.750 -70.367  2.934   1.00 46.04  ? 149 VAL A O   1 
ATOM 1122 C CB  . VAL A 1 151 ? 35.614 -73.406  3.178   1.00 42.66  ? 149 VAL A CB  1 
ATOM 1123 C CG1 . VAL A 1 151 ? 36.661 -73.389  2.068   1.00 43.93  ? 149 VAL A CG1 1 
ATOM 1124 C CG2 . VAL A 1 151 ? 35.633 -74.720  3.950   1.00 40.92  ? 149 VAL A CG2 1 
ATOM 1125 N N   . HIS A 1 152 ? 34.491 -70.456  2.974   1.00 47.30  ? 150 HIS A N   1 
ATOM 1126 C CA  . HIS A 1 152 ? 34.302 -69.271  2.146   1.00 55.93  ? 150 HIS A CA  1 
ATOM 1127 C C   . HIS A 1 152 ? 34.934 -68.038  2.789   1.00 58.93  ? 150 HIS A C   1 
ATOM 1128 O O   . HIS A 1 152 ? 35.558 -67.226  2.100   1.00 55.94  ? 150 HIS A O   1 
ATOM 1129 C CB  . HIS A 1 152 ? 32.827 -69.006  1.834   1.00 57.72  ? 150 HIS A CB  1 
ATOM 1130 C CG  . HIS A 1 152 ? 32.294 -69.856  0.732   1.00 58.45  ? 150 HIS A CG  1 
ATOM 1131 N ND1 . HIS A 1 152 ? 31.459 -69.345  -0.233  1.00 57.27  ? 150 HIS A ND1 1 
ATOM 1132 C CD2 . HIS A 1 152 ? 32.475 -71.153  0.429   1.00 55.91  ? 150 HIS A CD2 1 
ATOM 1133 C CE1 . HIS A 1 152 ? 31.135 -70.318  -1.071  1.00 59.69  ? 150 HIS A CE1 1 
ATOM 1134 N NE2 . HIS A 1 152 ? 31.743 -71.426  -0.692  1.00 54.57  ? 150 HIS A NE2 1 
ATOM 1135 N N   . ILE A 1 153 ? 34.786 -67.922  4.114   1.00 57.65  ? 151 ILE A N   1 
ATOM 1136 C CA  . ILE A 1 153 ? 35.300 -66.771  4.830   1.00 56.63  ? 151 ILE A CA  1 
ATOM 1137 C C   . ILE A 1 153 ? 36.816 -66.855  4.930   1.00 51.25  ? 151 ILE A C   1 
ATOM 1138 O O   . ILE A 1 153 ? 37.495 -65.838  4.776   1.00 46.78  ? 151 ILE A O   1 
ATOM 1139 C CB  . ILE A 1 153 ? 34.652 -66.660  6.212   1.00 63.04  ? 151 ILE A CB  1 
ATOM 1140 C CG1 . ILE A 1 153 ? 33.152 -66.434  6.080   1.00 68.98  ? 151 ILE A CG1 1 
ATOM 1141 C CG2 . ILE A 1 153 ? 35.326 -65.528  6.979   1.00 68.63  ? 151 ILE A CG2 1 
ATOM 1142 C CD1 . ILE A 1 153 ? 32.365 -66.583  7.363   1.00 69.42  ? 151 ILE A CD1 1 
ATOM 1143 N N   . ALA A 1 154 ? 37.315 -68.064  5.218   1.00 46.35  ? 152 ALA A N   1 
ATOM 1144 C CA  . ALA A 1 154 ? 38.741 -68.334  5.256   1.00 48.43  ? 152 ALA A CA  1 
ATOM 1145 C C   . ALA A 1 154 ? 39.388 -67.944  3.933   1.00 56.10  ? 152 ALA A C   1 
ATOM 1146 O O   . ALA A 1 154 ? 40.359 -67.192  3.875   1.00 55.62  ? 152 ALA A O   1 
ATOM 1147 C CB  . ALA A 1 154 ? 38.961 -69.802  5.527   1.00 51.25  ? 152 ALA A CB  1 
ATOM 1148 N N   . VAL A 1 155 ? 38.834 -68.502  2.860   1.00 62.53  ? 153 VAL A N   1 
ATOM 1149 C CA  . VAL A 1 155 ? 39.385 -68.316  1.533   1.00 62.20  ? 153 VAL A CA  1 
ATOM 1150 C C   . VAL A 1 155 ? 39.433 -66.822  1.238   1.00 62.64  ? 153 VAL A C   1 
ATOM 1151 O O   . VAL A 1 155 ? 40.451 -66.327  0.771   1.00 71.69  ? 153 VAL A O   1 
ATOM 1152 C CB  . VAL A 1 155 ? 38.571 -69.090  0.481   1.00 59.38  ? 153 VAL A CB  1 
ATOM 1153 C CG1 . VAL A 1 155 ? 38.998 -68.728  -0.937  1.00 58.10  ? 153 VAL A CG1 1 
ATOM 1154 C CG2 . VAL A 1 155 ? 38.649 -70.601  0.716   1.00 56.94  ? 153 VAL A CG2 1 
ATOM 1155 N N   . LEU A 1 156 ? 38.359 -66.101  1.571   1.00 56.98  ? 154 LEU A N   1 
ATOM 1156 C CA  . LEU A 1 156 ? 38.309 -64.675  1.297   1.00 58.91  ? 154 LEU A CA  1 
ATOM 1157 C C   . LEU A 1 156 ? 39.426 -63.939  2.042   1.00 58.42  ? 154 LEU A C   1 
ATOM 1158 O O   . LEU A 1 156 ? 40.081 -63.079  1.453   1.00 63.74  ? 154 LEU A O   1 
ATOM 1159 C CB  . LEU A 1 156 ? 36.929 -64.125  1.653   1.00 61.96  ? 154 LEU A CB  1 
ATOM 1160 C CG  . LEU A 1 156 ? 35.808 -64.379  0.642   1.00 61.01  ? 154 LEU A CG  1 
ATOM 1161 C CD1 . LEU A 1 156 ? 34.470 -64.018  1.259   1.00 56.81  ? 154 LEU A CD1 1 
ATOM 1162 C CD2 . LEU A 1 156 ? 36.030 -63.570  -0.617  1.00 66.57  ? 154 LEU A CD2 1 
ATOM 1163 N N   . THR A 1 157 ? 39.639 -64.265  3.325   1.00 58.92  ? 155 THR A N   1 
ATOM 1164 C CA  . THR A 1 157 ? 40.627 -63.557  4.133   1.00 66.58  ? 155 THR A CA  1 
ATOM 1165 C C   . THR A 1 157 ? 42.018 -63.764  3.542   1.00 67.35  ? 155 THR A C   1 
ATOM 1166 O O   . THR A 1 157 ? 42.804 -62.822  3.446   1.00 69.03  ? 155 THR A O   1 
ATOM 1167 C CB  . THR A 1 157 ? 40.610 -63.992  5.595   1.00 62.36  ? 155 THR A CB  1 
ATOM 1168 O OG1 . THR A 1 157 ? 40.824 -65.392  5.517   1.00 89.31  ? 155 THR A OG1 1 
ATOM 1169 C CG2 . THR A 1 157 ? 39.302 -63.698  6.300   1.00 58.84  ? 155 THR A CG2 1 
ATOM 1170 N N   . LEU A 1 158 ? 42.317 -64.997  3.133   1.00 61.94  ? 156 LEU A N   1 
ATOM 1171 C CA  . LEU A 1 158 ? 43.642 -65.302  2.628   1.00 60.50  ? 156 LEU A CA  1 
ATOM 1172 C C   . LEU A 1 158 ? 43.852 -64.617  1.279   1.00 62.99  ? 156 LEU A C   1 
ATOM 1173 O O   . LEU A 1 158 ? 44.945 -64.131  0.985   1.00 67.12  ? 156 LEU A O   1 
ATOM 1174 C CB  . LEU A 1 158 ? 43.793 -66.816  2.532   1.00 60.36  ? 156 LEU A CB  1 
ATOM 1175 C CG  . LEU A 1 158 ? 43.868 -67.569  3.859   1.00 61.90  ? 156 LEU A CG  1 
ATOM 1176 C CD1 . LEU A 1 158 ? 44.018 -69.044  3.638   1.00 66.48  ? 156 LEU A CD1 1 
ATOM 1177 C CD2 . LEU A 1 158 ? 45.039 -67.071  4.669   1.00 68.30  ? 156 LEU A CD2 1 
ATOM 1178 N N   . LEU A 1 159 ? 42.798 -64.596  0.456   1.00 62.89  ? 157 LEU A N   1 
ATOM 1179 C CA  . LEU A 1 159 ? 42.885 -63.997  -0.861  1.00 63.23  ? 157 LEU A CA  1 
ATOM 1180 C C   . LEU A 1 159 ? 43.165 -62.508  -0.720  1.00 66.20  ? 157 LEU A C   1 
ATOM 1181 O O   . LEU A 1 159 ? 43.880 -61.933  -1.535  1.00 68.89  ? 157 LEU A O   1 
ATOM 1182 C CB  . LEU A 1 159 ? 41.607 -64.222  -1.657  1.00 66.37  ? 157 LEU A CB  1 
ATOM 1183 C CG  . LEU A 1 159 ? 41.399 -65.628  -2.221  1.00 72.53  ? 157 LEU A CG  1 
ATOM 1184 C CD1 . LEU A 1 159 ? 40.034 -65.625  -2.900  1.00 78.31  ? 157 LEU A CD1 1 
ATOM 1185 C CD2 . LEU A 1 159 ? 42.484 -66.068  -3.201  1.00 75.33  ? 157 LEU A CD2 1 
ATOM 1186 N N   . ASP A 1 160 ? 42.587 -61.900  0.318   1.00 67.11  ? 158 ASP A N   1 
ATOM 1187 C CA  . ASP A 1 160 ? 42.740 -60.474  0.530   1.00 68.32  ? 158 ASP A CA  1 
ATOM 1188 C C   . ASP A 1 160 ? 44.162 -60.181  0.985   1.00 62.31  ? 158 ASP A C   1 
ATOM 1189 O O   . ASP A 1 160 ? 44.715 -59.171  0.569   1.00 60.40  ? 158 ASP A O   1 
ATOM 1190 C CB  . ASP A 1 160 ? 41.668 -59.925  1.447   1.00 75.95  ? 158 ASP A CB  1 
ATOM 1191 C CG  . ASP A 1 160 ? 40.298 -59.773  0.802   1.00 88.66  ? 158 ASP A CG  1 
ATOM 1192 O OD1 . ASP A 1 160 ? 40.033 -60.440  -0.240  1.00 96.68  ? 158 ASP A OD1 1 
ATOM 1193 O OD2 . ASP A 1 160 ? 39.516 -58.963  1.333   1.00 97.24  ? 158 ASP A OD2 1 
ATOM 1194 N N   . HIS A 1 161 ? 44.747 -61.076  1.792   1.00 59.09  ? 159 HIS A N   1 
ATOM 1195 C CA  . HIS A 1 161 ? 46.166 -60.982  2.109   1.00 59.53  ? 159 HIS A CA  1 
ATOM 1196 C C   . HIS A 1 161 ? 46.974 -61.110  0.821   1.00 59.73  ? 159 HIS A C   1 
ATOM 1197 O O   . HIS A 1 161 ? 47.904 -60.344  0.585   1.00 57.69  ? 159 HIS A O   1 
ATOM 1198 C CB  . HIS A 1 161 ? 46.604 -62.023  3.144   1.00 60.39  ? 159 HIS A CB  1 
ATOM 1199 C CG  . HIS A 1 161 ? 46.184 -61.697  4.532   1.00 61.94  ? 159 HIS A CG  1 
ATOM 1200 N ND1 . HIS A 1 161 ? 45.498 -60.535  4.818   1.00 63.79  ? 159 HIS A ND1 1 
ATOM 1201 C CD2 . HIS A 1 161 ? 46.295 -62.374  5.677   1.00 61.66  ? 159 HIS A CD2 1 
ATOM 1202 C CE1 . HIS A 1 161 ? 45.237 -60.496  6.117   1.00 63.81  ? 159 HIS A CE1 1 
ATOM 1203 N NE2 . HIS A 1 161 ? 45.712 -61.606  6.659   1.00 68.87  ? 159 HIS A NE2 1 
ATOM 1204 N N   . LEU A 1 162 ? 46.578 -62.063  -0.025  1.00 60.40  ? 160 LEU A N   1 
ATOM 1205 C CA  . LEU A 1 162 ? 47.302 -62.330  -1.254  1.00 58.38  ? 160 LEU A CA  1 
ATOM 1206 C C   . LEU A 1 162 ? 47.367 -61.066  -2.116  1.00 57.29  ? 160 LEU A C   1 
ATOM 1207 O O   . LEU A 1 162 ? 48.439 -60.648  -2.539  1.00 57.42  ? 160 LEU A O   1 
ATOM 1208 C CB  . LEU A 1 162 ? 46.662 -63.515  -1.977  1.00 52.48  ? 160 LEU A CB  1 
ATOM 1209 C CG  . LEU A 1 162 ? 47.361 -63.940  -3.268  1.00 58.26  ? 160 LEU A CG  1 
ATOM 1210 C CD1 . LEU A 1 162 ? 48.872 -63.994  -3.103  1.00 60.44  ? 160 LEU A CD1 1 
ATOM 1211 C CD2 . LEU A 1 162 ? 46.858 -65.282  -3.750  1.00 62.03  ? 160 LEU A CD2 1 
ATOM 1212 N N   . LEU A 1 163 ? 46.216 -60.428  -2.327  1.00 58.16  ? 161 LEU A N   1 
ATOM 1213 C CA  . LEU A 1 163 ? 46.116 -59.298  -3.237  1.00 59.01  ? 161 LEU A CA  1 
ATOM 1214 C C   . LEU A 1 163 ? 46.894 -58.094  -2.708  1.00 64.02  ? 161 LEU A C   1 
ATOM 1215 O O   . LEU A 1 163 ? 47.366 -57.272  -3.491  1.00 64.69  ? 161 LEU A O   1 
ATOM 1216 C CB  . LEU A 1 163 ? 44.638 -58.962  -3.424  1.00 58.25  ? 161 LEU A CB  1 
ATOM 1217 C CG  . LEU A 1 163 ? 43.811 -59.991  -4.201  1.00 57.39  ? 161 LEU A CG  1 
ATOM 1218 C CD1 . LEU A 1 163 ? 42.361 -59.956  -3.758  1.00 64.35  ? 161 LEU A CD1 1 
ATOM 1219 C CD2 . LEU A 1 163 ? 43.895 -59.762  -5.694  1.00 51.75  ? 161 LEU A CD2 1 
ATOM 1220 N N   . GLU A 1 164 ? 46.979 -57.967  -1.378  1.00 64.63  ? 162 GLU A N   1 
ATOM 1221 C CA  . GLU A 1 164 ? 47.813 -56.940  -0.783  1.00 66.59  ? 162 GLU A CA  1 
ATOM 1222 C C   . GLU A 1 164 ? 49.259 -57.235  -1.150  1.00 62.71  ? 162 GLU A C   1 
ATOM 1223 O O   . GLU A 1 164 ? 49.941 -56.353  -1.649  1.00 64.69  ? 162 GLU A O   1 
ATOM 1224 C CB  . GLU A 1 164 ? 47.618 -56.837  0.726   1.00 81.17  ? 162 GLU A CB  1 
ATOM 1225 C CG  . GLU A 1 164 ? 46.194 -56.433  1.108   1.00 102.55 ? 162 GLU A CG  1 
ATOM 1226 C CD  . GLU A 1 164 ? 45.818 -54.970  0.884   1.00 125.49 ? 162 GLU A CD  1 
ATOM 1227 O OE1 . GLU A 1 164 ? 46.570 -54.133  1.426   1.00 153.55 ? 162 GLU A OE1 1 
ATOM 1228 O OE2 . GLU A 1 164 ? 44.794 -54.652  0.215   1.00 126.27 ? 162 GLU A OE2 1 
ATOM 1229 N N   . THR A 1 165 ? 49.686 -58.490  -0.975  1.00 58.33  ? 163 THR A N   1 
ATOM 1230 C CA  . THR A 1 165 ? 51.066 -58.878  -1.227  1.00 57.34  ? 163 THR A CA  1 
ATOM 1231 C C   . THR A 1 165 ? 51.424 -58.676  -2.698  1.00 60.02  ? 163 THR A C   1 
ATOM 1232 O O   . THR A 1 165 ? 52.565 -58.353  -3.036  1.00 61.46  ? 163 THR A O   1 
ATOM 1233 C CB  . THR A 1 165 ? 51.274 -60.332  -0.815  1.00 55.55  ? 163 THR A CB  1 
ATOM 1234 O OG1 . THR A 1 165 ? 51.083 -60.362  0.591   1.00 57.82  ? 163 THR A OG1 1 
ATOM 1235 C CG2 . THR A 1 165 ? 52.678 -60.813  -1.104  1.00 56.00  ? 163 THR A CG2 1 
ATOM 1236 N N   . MET A 1 166 ? 50.445 -58.929  -3.567  1.00 64.45  ? 164 MET A N   1 
ATOM 1237 C CA  . MET A 1 166 ? 50.664 -58.874  -4.998  1.00 64.41  ? 164 MET A CA  1 
ATOM 1238 C C   . MET A 1 166 ? 50.638 -57.420  -5.446  1.00 70.07  ? 164 MET A C   1 
ATOM 1239 O O   . MET A 1 166 ? 51.411 -57.019  -6.319  1.00 75.42  ? 164 MET A O   1 
ATOM 1240 C CB  . MET A 1 166 ? 49.589 -59.657  -5.751  1.00 60.54  ? 164 MET A CB  1 
ATOM 1241 C CG  . MET A 1 166 ? 49.677 -61.154  -5.560  1.00 58.29  ? 164 MET A CG  1 
ATOM 1242 S SD  . MET A 1 166 ? 48.917 -61.952  -6.983  1.00 61.77  ? 164 MET A SD  1 
ATOM 1243 C CE  . MET A 1 166 ? 47.223 -61.517  -6.569  1.00 71.52  ? 164 MET A CE  1 
ATOM 1244 N N   . GLU A 1 167 ? 49.732 -56.647  -4.837  1.00 69.72  ? 165 GLU A N   1 
ATOM 1245 C CA  . GLU A 1 167 ? 49.654 -55.227  -5.111  1.00 70.07  ? 165 GLU A CA  1 
ATOM 1246 C C   . GLU A 1 167 ? 51.030 -54.627  -4.826  1.00 70.43  ? 165 GLU A C   1 
ATOM 1247 O O   . GLU A 1 167 ? 51.553 -53.843  -5.620  1.00 69.77  ? 165 GLU A O   1 
ATOM 1248 C CB  . GLU A 1 167 ? 48.482 -54.625  -4.336  1.00 72.55  ? 165 GLU A CB  1 
ATOM 1249 C CG  . GLU A 1 167 ? 48.058 -53.264  -4.869  1.00 90.12  ? 165 GLU A CG  1 
ATOM 1250 C CD  . GLU A 1 167 ? 47.347 -53.319  -6.217  1.00 102.80 ? 165 GLU A CD  1 
ATOM 1251 O OE1 . GLU A 1 167 ? 46.209 -53.863  -6.284  1.00 101.88 ? 165 GLU A OE1 1 
ATOM 1252 O OE2 . GLU A 1 167 ? 47.946 -52.807  -7.202  1.00 95.24  ? 165 GLU A OE2 1 
ATOM 1253 N N   . ARG A 1 168 ? 51.645 -55.066  -3.717  1.00 72.49  ? 166 ARG A N   1 
ATOM 1254 C CA  . ARG A 1 168 ? 52.988 -54.638  -3.355  1.00 68.67  ? 166 ARG A CA  1 
ATOM 1255 C C   . ARG A 1 168 ? 53.993 -55.173  -4.376  1.00 63.37  ? 166 ARG A C   1 
ATOM 1256 O O   . ARG A 1 168 ? 54.876 -54.447  -4.800  1.00 59.55  ? 166 ARG A O   1 
ATOM 1257 C CB  . ARG A 1 168 ? 53.363 -55.025  -1.917  1.00 70.64  ? 166 ARG A CB  1 
ATOM 1258 C CG  . ARG A 1 168 ? 53.113 -53.978  -0.836  1.00 77.44  ? 166 ARG A CG  1 
ATOM 1259 C CD  . ARG A 1 168 ? 53.564 -54.464  0.559   1.00 91.24  ? 166 ARG A CD  1 
ATOM 1260 N NE  . ARG A 1 168 ? 52.616 -55.418  1.162   1.00 105.00 ? 166 ARG A NE  1 
ATOM 1261 C CZ  . ARG A 1 168 ? 52.849 -56.649  1.661   1.00 97.49  ? 166 ARG A CZ  1 
ATOM 1262 N NH1 . ARG A 1 168 ? 54.077 -57.110  1.856   1.00 92.02  ? 166 ARG A NH1 1 
ATOM 1263 N NH2 . ARG A 1 168 ? 51.820 -57.409  2.012   1.00 89.98  ? 166 ARG A NH2 1 
ATOM 1264 N N   . MET A 1 169 ? 53.856 -56.435  -4.791  1.00 65.85  ? 167 MET A N   1 
ATOM 1265 C CA  . MET A 1 169 ? 54.770 -57.034  -5.756  1.00 58.35  ? 167 MET A CA  1 
ATOM 1266 C C   . MET A 1 169 ? 54.706 -56.261  -7.071  1.00 52.79  ? 167 MET A C   1 
ATOM 1267 O O   . MET A 1 169 ? 55.741 -55.998  -7.671  1.00 52.66  ? 167 MET A O   1 
ATOM 1268 C CB  . MET A 1 169 ? 54.448 -58.518  -5.986  1.00 58.45  ? 167 MET A CB  1 
ATOM 1269 C CG  . MET A 1 169 ? 55.522 -59.309  -6.726  1.00 59.18  ? 167 MET A CG  1 
ATOM 1270 S SD  . MET A 1 169 ? 55.369 -61.120  -6.736  1.00 58.60  ? 167 MET A SD  1 
ATOM 1271 C CE  . MET A 1 169 ? 53.677 -61.378  -7.290  1.00 55.77  ? 167 MET A CE  1 
ATOM 1272 N N   . ARG A 1 170 ? 53.509 -55.863  -7.511  1.00 53.22  ? 168 ARG A N   1 
ATOM 1273 C CA  . ARG A 1 170 ? 53.415 -55.179  -8.794  1.00 61.06  ? 168 ARG A CA  1 
ATOM 1274 C C   . ARG A 1 170 ? 54.098 -53.820  -8.687  1.00 64.12  ? 168 ARG A C   1 
ATOM 1275 O O   . ARG A 1 170 ? 54.744 -53.384  -9.634  1.00 57.21  ? 168 ARG A O   1 
ATOM 1276 C CB  . ARG A 1 170 ? 52.017 -55.043  -9.407  1.00 59.85  ? 168 ARG A CB  1 
ATOM 1277 C CG  . ARG A 1 170 ? 51.092 -54.008  -8.789  1.00 67.01  ? 168 ARG A CG  1 
ATOM 1278 C CD  . ARG A 1 170 ? 50.256 -53.322  -9.844  1.00 69.97  ? 168 ARG A CD  1 
ATOM 1279 N NE  . ARG A 1 170 ? 51.028 -52.363  -10.639 1.00 75.95  ? 168 ARG A NE  1 
ATOM 1280 C CZ  . ARG A 1 170 ? 51.440 -51.164  -10.232 1.00 88.25  ? 168 ARG A CZ  1 
ATOM 1281 N NH1 . ARG A 1 170 ? 51.378 -50.846  -8.953  1.00 99.26  ? 168 ARG A NH1 1 
ATOM 1282 N NH2 . ARG A 1 170 ? 51.947 -50.297  -11.096 1.00 88.77  ? 168 ARG A NH2 1 
ATOM 1283 N N   . ASP A 1 171 ? 53.962 -53.172  -7.522  1.00 68.25  ? 169 ASP A N   1 
ATOM 1284 C CA  . ASP A 1 171 ? 54.620 -51.903  -7.276  1.00 63.83  ? 169 ASP A CA  1 
ATOM 1285 C C   . ASP A 1 171 ? 56.120 -52.108  -7.446  1.00 55.19  ? 169 ASP A C   1 
ATOM 1286 O O   . ASP A 1 171 ? 56.783 -51.287  -8.057  1.00 62.27  ? 169 ASP A O   1 
ATOM 1287 C CB  . ASP A 1 171 ? 54.241 -51.316  -5.923  1.00 69.24  ? 169 ASP A CB  1 
ATOM 1288 C CG  . ASP A 1 171 ? 52.842 -50.726  -5.801  1.00 76.44  ? 169 ASP A CG  1 
ATOM 1289 O OD1 . ASP A 1 171 ? 52.205 -50.516  -6.845  1.00 81.85  ? 169 ASP A OD1 1 
ATOM 1290 O OD2 . ASP A 1 171 ? 52.399 -50.481  -4.657  1.00 83.19  ? 169 ASP A OD2 1 
ATOM 1291 N N   . ALA A 1 172 ? 56.626 -53.240  -6.959  1.00 51.50  ? 170 ALA A N   1 
ATOM 1292 C CA  . ALA A 1 172 ? 58.051 -53.523  -6.974  1.00 56.32  ? 170 ALA A CA  1 
ATOM 1293 C C   . ALA A 1 172 ? 58.560 -53.637  -8.405  1.00 58.96  ? 170 ALA A C   1 
ATOM 1294 O O   . ALA A 1 172 ? 59.568 -53.023  -8.768  1.00 56.83  ? 170 ALA A O   1 
ATOM 1295 C CB  . ALA A 1 172 ? 58.340 -54.790  -6.194  1.00 57.12  ? 170 ALA A CB  1 
ATOM 1296 N N   . PHE A 1 173 ? 57.859 -54.445  -9.205  1.00 58.29  ? 171 PHE A N   1 
ATOM 1297 C CA  . PHE A 1 173 ? 58.233 -54.626  -10.595 1.00 56.85  ? 171 PHE A CA  1 
ATOM 1298 C C   . PHE A 1 173 ? 58.158 -53.296  -11.349 1.00 59.76  ? 171 PHE A C   1 
ATOM 1299 O O   . PHE A 1 173 ? 59.038 -52.984  -12.157 1.00 54.43  ? 171 PHE A O   1 
ATOM 1300 C CB  . PHE A 1 173 ? 57.312 -55.687  -11.191 1.00 50.78  ? 171 PHE A CB  1 
ATOM 1301 C CG  . PHE A 1 173 ? 57.834 -57.099  -11.010 1.00 48.24  ? 171 PHE A CG  1 
ATOM 1302 C CD1 . PHE A 1 173 ? 58.809 -57.608  -11.858 1.00 50.56  ? 171 PHE A CD1 1 
ATOM 1303 C CD2 . PHE A 1 173 ? 57.332 -57.919  -10.017 1.00 47.37  ? 171 PHE A CD2 1 
ATOM 1304 C CE1 . PHE A 1 173 ? 59.276 -58.906  -11.708 1.00 49.76  ? 171 PHE A CE1 1 
ATOM 1305 C CE2 . PHE A 1 173 ? 57.815 -59.213  -9.857  1.00 48.02  ? 171 PHE A CE2 1 
ATOM 1306 C CZ  . PHE A 1 173 ? 58.786 -59.703  -10.697 1.00 47.71  ? 171 PHE A CZ  1 
ATOM 1307 N N   . ALA A 1 174 ? 57.090 -52.531  -11.076 1.00 56.48  ? 172 ALA A N   1 
ATOM 1308 C CA  . ALA A 1 174 ? 56.829 -51.268  -11.743 1.00 56.44  ? 172 ALA A CA  1 
ATOM 1309 C C   . ALA A 1 174 ? 57.993 -50.288  -11.567 1.00 63.29  ? 172 ALA A C   1 
ATOM 1310 O O   . ALA A 1 174 ? 58.312 -49.553  -12.507 1.00 53.24  ? 172 ALA A O   1 
ATOM 1311 C CB  . ALA A 1 174 ? 55.534 -50.700  -11.219 1.00 56.58  ? 172 ALA A CB  1 
ATOM 1312 N N   . GLU A 1 175 ? 58.613 -50.273  -10.369 1.00 68.49  ? 173 GLU A N   1 
ATOM 1313 C CA  . GLU A 1 175 ? 59.783 -49.443  -10.109 1.00 75.48  ? 173 GLU A CA  1 
ATOM 1314 C C   . GLU A 1 175 ? 60.934 -49.871  -11.016 1.00 75.16  ? 173 GLU A C   1 
ATOM 1315 O O   . GLU A 1 175 ? 61.595 -49.034  -11.628 1.00 73.33  ? 173 GLU A O   1 
ATOM 1316 C CB  . GLU A 1 175 ? 60.220 -49.474  -8.645  1.00 80.27  ? 173 GLU A CB  1 
ATOM 1317 C CG  . GLU A 1 175 ? 59.354 -48.584  -7.757  1.00 93.06  ? 173 GLU A CG  1 
ATOM 1318 C CD  . GLU A 1 175 ? 59.462 -48.829  -6.256  1.00 113.25 ? 173 GLU A CD  1 
ATOM 1319 O OE1 . GLU A 1 175 ? 59.955 -49.895  -5.804  1.00 126.13 ? 173 GLU A OE1 1 
ATOM 1320 O OE2 . GLU A 1 175 ? 59.032 -47.912  -5.524  1.00 132.83 ? 173 GLU A OE2 1 
ATOM 1321 N N   . LYS A 1 176 ? 61.158 -51.182  -11.122 1.00 71.21  ? 174 LYS A N   1 
ATOM 1322 C CA  . LYS A 1 176 ? 62.255 -51.695  -11.928 1.00 68.90  ? 174 LYS A CA  1 
ATOM 1323 C C   . LYS A 1 176 ? 62.006 -51.419  -13.410 1.00 76.54  ? 174 LYS A C   1 
ATOM 1324 O O   . LYS A 1 176 ? 62.954 -51.374  -14.192 1.00 73.71  ? 174 LYS A O   1 
ATOM 1325 C CB  . LYS A 1 176 ? 62.433 -53.186  -11.649 1.00 64.42  ? 174 LYS A CB  1 
ATOM 1326 C CG  . LYS A 1 176 ? 62.784 -53.467  -10.218 1.00 70.06  ? 174 LYS A CG  1 
ATOM 1327 C CD  . LYS A 1 176 ? 64.141 -52.917  -9.806  1.00 75.21  ? 174 LYS A CD  1 
ATOM 1328 C CE  . LYS A 1 176 ? 64.299 -52.753  -8.324  1.00 79.47  ? 174 LYS A CE  1 
ATOM 1329 N NZ  . LYS A 1 176 ? 65.736 -52.670  -8.057  1.00 87.69  ? 174 LYS A NZ  1 
ATOM 1330 N N   . ALA A 1 177 ? 60.731 -51.254  -13.789 1.00 72.00  ? 175 ALA A N   1 
ATOM 1331 C CA  . ALA A 1 177 ? 60.382 -50.842  -15.135 1.00 72.87  ? 175 ALA A CA  1 
ATOM 1332 C C   . ALA A 1 177 ? 60.950 -49.450  -15.395 1.00 80.68  ? 175 ALA A C   1 
ATOM 1333 O O   . ALA A 1 177 ? 61.595 -49.232  -16.423 1.00 94.21  ? 175 ALA A O   1 
ATOM 1334 C CB  . ALA A 1 177 ? 58.879 -50.874  -15.326 1.00 74.75  ? 175 ALA A CB  1 
ATOM 1335 N N   . LYS A 1 178 ? 60.718 -48.543  -14.438 1.00 77.55  ? 176 LYS A N   1 
ATOM 1336 C CA  . LYS A 1 178 ? 61.157 -47.162  -14.547 1.00 73.77  ? 176 LYS A CA  1 
ATOM 1337 C C   . LYS A 1 178 ? 62.677 -47.102  -14.443 1.00 73.69  ? 176 LYS A C   1 
ATOM 1338 O O   . LYS A 1 178 ? 63.334 -46.478  -15.273 1.00 63.78  ? 176 LYS A O   1 
ATOM 1339 C CB  . LYS A 1 178 ? 60.409 -46.301  -13.521 1.00 77.85  ? 176 LYS A CB  1 
ATOM 1340 C CG  . LYS A 1 178 ? 58.891 -46.410  -13.679 1.00 96.78  ? 176 LYS A CG  1 
ATOM 1341 C CD  . LYS A 1 178 ? 58.092 -45.105  -13.752 1.00 104.53 ? 176 LYS A CD  1 
ATOM 1342 C CE  . LYS A 1 178 ? 56.989 -45.152  -14.788 1.00 109.55 ? 176 LYS A CE  1 
ATOM 1343 N NZ  . LYS A 1 178 ? 56.874 -43.899  -15.549 1.00 116.57 ? 176 LYS A NZ  1 
ATOM 1344 N N   . ALA A 1 179 ? 63.237 -47.807  -13.454 1.00 81.04  ? 177 ALA A N   1 
ATOM 1345 C CA  . ALA A 1 179 ? 64.674 -47.792  -13.218 1.00 81.99  ? 177 ALA A CA  1 
ATOM 1346 C C   . ALA A 1 179 ? 65.450 -48.240  -14.456 1.00 75.55  ? 177 ALA A C   1 
ATOM 1347 O O   . ALA A 1 179 ? 66.480 -47.652  -14.779 1.00 73.14  ? 177 ALA A O   1 
ATOM 1348 C CB  . ALA A 1 179 ? 65.005 -48.664  -12.032 1.00 85.02  ? 177 ALA A CB  1 
ATOM 1349 N N   . PHE A 1 180 ? 64.941 -49.276  -15.135 1.00 69.75  ? 178 PHE A N   1 
ATOM 1350 C CA  . PHE A 1 180 ? 65.665 -49.932  -16.209 1.00 68.78  ? 178 PHE A CA  1 
ATOM 1351 C C   . PHE A 1 180 ? 65.168 -49.480  -17.576 1.00 66.58  ? 178 PHE A C   1 
ATOM 1352 O O   . PHE A 1 180 ? 65.567 -50.045  -18.591 1.00 60.49  ? 178 PHE A O   1 
ATOM 1353 C CB  . PHE A 1 180 ? 65.486 -51.450  -16.154 1.00 72.55  ? 178 PHE A CB  1 
ATOM 1354 C CG  . PHE A 1 180 ? 66.030 -52.142  -14.916 1.00 72.79  ? 178 PHE A CG  1 
ATOM 1355 C CD1 . PHE A 1 180 ? 67.112 -51.626  -14.221 1.00 69.71  ? 178 PHE A CD1 1 
ATOM 1356 C CD2 . PHE A 1 180 ? 65.462 -53.330  -14.469 1.00 77.95  ? 178 PHE A CD2 1 
ATOM 1357 C CE1 . PHE A 1 180 ? 67.589 -52.279  -13.098 1.00 72.75  ? 178 PHE A CE1 1 
ATOM 1358 C CE2 . PHE A 1 180 ? 65.957 -53.981  -13.350 1.00 76.54  ? 178 PHE A CE2 1 
ATOM 1359 C CZ  . PHE A 1 180 ? 67.025 -53.460  -12.674 1.00 70.47  ? 178 PHE A CZ  1 
ATOM 1360 N N   . ASP A 1 181 ? 64.318 -48.455  -17.605 1.00 69.21  ? 179 ASP A N   1 
ATOM 1361 C CA  . ASP A 1 181 ? 63.724 -48.011  -18.854 1.00 73.64  ? 179 ASP A CA  1 
ATOM 1362 C C   . ASP A 1 181 ? 64.783 -47.616  -19.880 1.00 76.29  ? 179 ASP A C   1 
ATOM 1363 O O   . ASP A 1 181 ? 64.618 -47.908  -21.066 1.00 73.11  ? 179 ASP A O   1 
ATOM 1364 C CB  . ASP A 1 181 ? 62.783 -46.842  -18.659 1.00 75.78  ? 179 ASP A CB  1 
ATOM 1365 C CG  . ASP A 1 181 ? 61.829 -46.734  -19.819 1.00 70.51  ? 179 ASP A CG  1 
ATOM 1366 O OD1 . ASP A 1 181 ? 60.901 -47.552  -19.841 1.00 88.33  ? 179 ASP A OD1 1 
ATOM 1367 O OD2 . ASP A 1 181 ? 62.118 -45.944  -20.716 1.00 67.17  ? 179 ASP A OD2 1 
ATOM 1368 N N   . PRO A 1 182 ? 65.872 -46.908  -19.490 1.00 76.16  ? 180 PRO A N   1 
ATOM 1369 C CA  . PRO A 1 182 ? 66.875 -46.473  -20.458 1.00 69.83  ? 180 PRO A CA  1 
ATOM 1370 C C   . PRO A 1 182 ? 67.932 -47.496  -20.857 1.00 61.00  ? 180 PRO A C   1 
ATOM 1371 O O   . PRO A 1 182 ? 68.695 -47.210  -21.768 1.00 67.21  ? 180 PRO A O   1 
ATOM 1372 C CB  . PRO A 1 182 ? 67.494 -45.282  -19.716 1.00 71.32  ? 180 PRO A CB  1 
ATOM 1373 C CG  . PRO A 1 182 ? 67.535 -45.759  -18.301 1.00 71.23  ? 180 PRO A CG  1 
ATOM 1374 C CD  . PRO A 1 182 ? 66.187 -46.439  -18.128 1.00 76.17  ? 180 PRO A CD  1 
ATOM 1375 N N   . TYR A 1 183 ? 67.976 -48.663  -20.207 1.00 57.64  ? 181 TYR A N   1 
ATOM 1376 C CA  . TYR A 1 183 ? 69.028 -49.634  -20.486 1.00 73.64  ? 181 TYR A CA  1 
ATOM 1377 C C   . TYR A 1 183 ? 68.682 -50.498  -21.704 1.00 75.15  ? 181 TYR A C   1 
ATOM 1378 O O   . TYR A 1 183 ? 67.674 -51.190  -21.720 1.00 79.28  ? 181 TYR A O   1 
ATOM 1379 C CB  . TYR A 1 183 ? 69.290 -50.463  -19.226 1.00 79.33  ? 181 TYR A CB  1 
ATOM 1380 C CG  . TYR A 1 183 ? 69.675 -49.636  -18.007 1.00 88.91  ? 181 TYR A CG  1 
ATOM 1381 C CD1 . TYR A 1 183 ? 70.427 -48.473  -18.133 1.00 95.23  ? 181 TYR A CD1 1 
ATOM 1382 C CD2 . TYR A 1 183 ? 69.283 -50.021  -16.728 1.00 95.38  ? 181 TYR A CD2 1 
ATOM 1383 C CE1 . TYR A 1 183 ? 70.784 -47.724  -17.025 1.00 102.27 ? 181 TYR A CE1 1 
ATOM 1384 C CE2 . TYR A 1 183 ? 69.641 -49.285  -15.610 1.00 97.42  ? 181 TYR A CE2 1 
ATOM 1385 C CZ  . TYR A 1 183 ? 70.388 -48.130  -15.762 1.00 105.09 ? 181 TYR A CZ  1 
ATOM 1386 O OH  . TYR A 1 183 ? 70.724 -47.384  -14.672 1.00 115.78 ? 181 TYR A OH  1 
ATOM 1387 N N   . ILE A 1 184 ? 69.555 -50.478  -22.715 1.00 79.69  ? 182 ILE A N   1 
ATOM 1388 C CA  . ILE A 1 184 ? 69.363 -51.221  -23.951 1.00 80.52  ? 182 ILE A CA  1 
ATOM 1389 C C   . ILE A 1 184 ? 70.025 -52.599  -23.819 1.00 84.65  ? 182 ILE A C   1 
ATOM 1390 O O   . ILE A 1 184 ? 71.062 -52.747  -23.164 1.00 80.33  ? 182 ILE A O   1 
ATOM 1391 C CB  . ILE A 1 184 ? 69.917 -50.409  -25.142 1.00 81.55  ? 182 ILE A CB  1 
ATOM 1392 C CG1 . ILE A 1 184 ? 69.464 -50.966  -26.485 1.00 84.59  ? 182 ILE A CG1 1 
ATOM 1393 C CG2 . ILE A 1 184 ? 71.441 -50.269  -25.085 1.00 85.12  ? 182 ILE A CG2 1 
ATOM 1394 C CD1 . ILE A 1 184 ? 68.033 -50.620  -26.842 1.00 92.64  ? 182 ILE A CD1 1 
ATOM 1395 N N   . LYS A 1 185 ? 69.406 -53.610  -24.447 1.00 81.44  ? 183 LYS A N   1 
ATOM 1396 C CA  . LYS A 1 185 ? 69.925 -54.970  -24.462 1.00 81.37  ? 183 LYS A CA  1 
ATOM 1397 C C   . LYS A 1 185 ? 69.438 -55.675  -25.723 1.00 78.86  ? 183 LYS A C   1 
ATOM 1398 O O   . LYS A 1 185 ? 68.635 -55.128  -26.474 1.00 74.17  ? 183 LYS A O   1 
ATOM 1399 C CB  . LYS A 1 185 ? 69.484 -55.764  -23.224 1.00 84.86  ? 183 LYS A CB  1 
ATOM 1400 C CG  . LYS A 1 185 ? 67.991 -55.687  -22.907 1.00 90.30  ? 183 LYS A CG  1 
ATOM 1401 C CD  . LYS A 1 185 ? 67.471 -56.789  -21.991 1.00 95.40  ? 183 LYS A CD  1 
ATOM 1402 C CE  . LYS A 1 185 ? 67.234 -58.074  -22.724 1.00 101.05 ? 183 LYS A CE  1 
ATOM 1403 N NZ  . LYS A 1 185 ? 66.947 -59.179  -21.809 1.00 110.31 ? 183 LYS A NZ  1 
ATOM 1404 N N   . MET A 1 186 ? 69.918 -56.906  -25.933 1.00 83.18  ? 184 MET A N   1 
ATOM 1405 C CA  . MET A 1 186 ? 69.437 -57.725  -27.033 1.00 88.29  ? 184 MET A CA  1 
ATOM 1406 C C   . MET A 1 186 ? 68.189 -58.488  -26.607 1.00 84.78  ? 184 MET A C   1 
ATOM 1407 O O   . MET A 1 186 ? 68.237 -59.323  -25.701 1.00 84.83  ? 184 MET A O   1 
ATOM 1408 C CB  . MET A 1 186 ? 70.486 -58.736  -27.504 1.00 97.61  ? 184 MET A CB  1 
ATOM 1409 C CG  . MET A 1 186 ? 71.441 -58.208  -28.573 1.00 104.93 ? 184 MET A CG  1 
ATOM 1410 S SD  . MET A 1 186 ? 70.631 -57.799  -30.133 1.00 108.85 ? 184 MET A SD  1 
ATOM 1411 C CE  . MET A 1 186 ? 70.414 -56.023  -29.948 1.00 118.85 ? 184 MET A CE  1 
ATOM 1412 N N   . GLY A 1 187 ? 67.075 -58.192  -27.285 1.00 80.57  ? 185 GLY A N   1 
ATOM 1413 C CA  . GLY A 1 187 ? 65.921 -59.069  -27.240 1.00 80.60  ? 185 GLY A CA  1 
ATOM 1414 C C   . GLY A 1 187 ? 66.296 -60.445  -27.783 1.00 78.64  ? 185 GLY A C   1 
ATOM 1415 O O   . GLY A 1 187 ? 67.078 -60.546  -28.729 1.00 82.55  ? 185 GLY A O   1 
ATOM 1416 N N   . ARG A 1 188 ? 65.771 -61.498  -27.149 1.00 70.42  ? 186 ARG A N   1 
ATOM 1417 C CA  . ARG A 1 188 ? 66.003 -62.844  -27.626 1.00 64.58  ? 186 ARG A CA  1 
ATOM 1418 C C   . ARG A 1 188 ? 64.693 -63.523  -27.983 1.00 67.85  ? 186 ARG A C   1 
ATOM 1419 O O   . ARG A 1 188 ? 63.666 -63.289  -27.360 1.00 76.64  ? 186 ARG A O   1 
ATOM 1420 C CB  . ARG A 1 188 ? 66.747 -63.632  -26.554 1.00 74.34  ? 186 ARG A CB  1 
ATOM 1421 C CG  . ARG A 1 188 ? 68.154 -63.104  -26.322 1.00 79.81  ? 186 ARG A CG  1 
ATOM 1422 C CD  . ARG A 1 188 ? 68.991 -64.087  -25.500 1.00 74.52  ? 186 ARG A CD  1 
ATOM 1423 N NE  . ARG A 1 188 ? 70.209 -63.491  -24.944 1.00 78.58  ? 186 ARG A NE  1 
ATOM 1424 C CZ  . ARG A 1 188 ? 70.243 -62.475  -24.083 1.00 77.24  ? 186 ARG A CZ  1 
ATOM 1425 N NH1 . ARG A 1 188 ? 69.118 -61.901  -23.694 1.00 82.89  ? 186 ARG A NH1 1 
ATOM 1426 N NH2 . ARG A 1 188 ? 71.403 -62.032  -23.621 1.00 70.15  ? 186 ARG A NH2 1 
ATOM 1427 N N   . ILE A 1 189 ? 64.797 -64.425  -28.957 1.00 70.50  ? 187 ILE A N   1 
ATOM 1428 C CA  . ILE A 1 189 ? 63.670 -65.072  -29.604 1.00 64.63  ? 187 ILE A CA  1 
ATOM 1429 C C   . ILE A 1 189 ? 64.123 -66.488  -29.933 1.00 69.26  ? 187 ILE A C   1 
ATOM 1430 O O   . ILE A 1 189 ? 65.067 -66.662  -30.692 1.00 81.86  ? 187 ILE A O   1 
ATOM 1431 C CB  . ILE A 1 189 ? 63.289 -64.213  -30.819 1.00 65.36  ? 187 ILE A CB  1 
ATOM 1432 C CG1 . ILE A 1 189 ? 62.172 -63.273  -30.449 1.00 84.83  ? 187 ILE A CG1 1 
ATOM 1433 C CG2 . ILE A 1 189 ? 62.950 -65.004  -32.079 1.00 63.66  ? 187 ILE A CG2 1 
ATOM 1434 C CD1 . ILE A 1 189 ? 61.782 -62.306  -31.556 1.00 95.16  ? 187 ILE A CD1 1 
ATOM 1435 N N   . HIS A 1 190 ? 63.516 -67.482  -29.281 1.00 72.61  ? 188 HIS A N   1 
ATOM 1436 C CA  . HIS A 1 190 ? 63.988 -68.861  -29.318 1.00 71.12  ? 188 HIS A CA  1 
ATOM 1437 C C   . HIS A 1 190 ? 65.385 -68.961  -28.702 1.00 71.56  ? 188 HIS A C   1 
ATOM 1438 O O   . HIS A 1 190 ? 66.099 -69.937  -28.961 1.00 72.50  ? 188 HIS A O   1 
ATOM 1439 C CB  . HIS A 1 190 ? 64.030 -69.456  -30.735 1.00 63.45  ? 188 HIS A CB  1 
ATOM 1440 C CG  . HIS A 1 190 ? 62.847 -69.252  -31.632 1.00 61.79  ? 188 HIS A CG  1 
ATOM 1441 N ND1 . HIS A 1 190 ? 62.333 -70.278  -32.393 1.00 64.63  ? 188 HIS A ND1 1 
ATOM 1442 C CD2 . HIS A 1 190 ? 62.100 -68.191  -31.938 1.00 63.88  ? 188 HIS A CD2 1 
ATOM 1443 C CE1 . HIS A 1 190 ? 61.322 -69.832  -33.132 1.00 66.33  ? 188 HIS A CE1 1 
ATOM 1444 N NE2 . HIS A 1 190 ? 61.157 -68.563  -32.867 1.00 61.19  ? 188 HIS A NE2 1 
ATOM 1445 N N   . LEU A 1 191 ? 65.735 -67.952  -27.876 1.00 68.41  ? 189 LEU A N   1 
ATOM 1446 C CA  . LEU A 1 191 ? 67.052 -67.799  -27.261 1.00 69.26  ? 189 LEU A CA  1 
ATOM 1447 C C   . LEU A 1 191 ? 68.083 -67.294  -28.280 1.00 68.29  ? 189 LEU A C   1 
ATOM 1448 O O   . LEU A 1 191 ? 69.247 -67.036  -27.924 1.00 66.72  ? 189 LEU A O   1 
ATOM 1449 C CB  . LEU A 1 191 ? 67.562 -69.055  -26.539 1.00 70.31  ? 189 LEU A CB  1 
ATOM 1450 C CG  . LEU A 1 191 ? 66.714 -69.585  -25.371 1.00 65.57  ? 189 LEU A CG  1 
ATOM 1451 C CD1 . LEU A 1 191 ? 67.297 -70.862  -24.798 1.00 57.79  ? 189 LEU A CD1 1 
ATOM 1452 C CD2 . LEU A 1 191 ? 66.496 -68.566  -24.256 1.00 68.42  ? 189 LEU A CD2 1 
ATOM 1453 N N   . GLN A 1 192 ? 67.651 -67.104  -29.538 1.00 65.30  ? 190 GLN A N   1 
ATOM 1454 C CA  . GLN A 1 192 ? 68.518 -66.530  -30.556 1.00 63.30  ? 190 GLN A CA  1 
ATOM 1455 C C   . GLN A 1 192 ? 68.419 -65.007  -30.486 1.00 63.61  ? 190 GLN A C   1 
ATOM 1456 O O   . GLN A 1 192 ? 67.349 -64.455  -30.216 1.00 58.63  ? 190 GLN A O   1 
ATOM 1457 C CB  . GLN A 1 192 ? 68.117 -67.018  -31.953 1.00 65.26  ? 190 GLN A CB  1 
ATOM 1458 C CG  . GLN A 1 192 ? 68.188 -68.526  -32.169 1.00 63.47  ? 190 GLN A CG  1 
ATOM 1459 C CD  . GLN A 1 192 ? 69.541 -69.092  -31.823 1.00 72.13  ? 190 GLN A CD  1 
ATOM 1460 O OE1 . GLN A 1 192 ? 69.730 -69.714  -30.772 1.00 95.52  ? 190 GLN A OE1 1 
ATOM 1461 N NE2 . GLN A 1 192 ? 70.519 -68.821  -32.670 1.00 73.80  ? 190 GLN A NE2 1 
ATOM 1462 N N   . ASP A 1 193 ? 69.551 -64.344  -30.742 1.00 63.55  ? 191 ASP A N   1 
ATOM 1463 C CA  . ASP A 1 193 ? 69.620 -62.889  -30.729 1.00 66.86  ? 191 ASP A CA  1 
ATOM 1464 C C   . ASP A 1 193 ? 68.672 -62.351  -31.793 1.00 70.23  ? 191 ASP A C   1 
ATOM 1465 O O   . ASP A 1 193 ? 68.646 -62.838  -32.919 1.00 71.47  ? 191 ASP A O   1 
ATOM 1466 C CB  . ASP A 1 193 ? 71.025 -62.365  -30.977 1.00 65.89  ? 191 ASP A CB  1 
ATOM 1467 C CG  . ASP A 1 193 ? 72.120 -63.192  -30.332 1.00 73.10  ? 191 ASP A CG  1 
ATOM 1468 O OD1 . ASP A 1 193 ? 71.736 -64.109  -29.537 1.00 96.24  ? 191 ASP A OD1 1 
ATOM 1469 O OD2 . ASP A 1 193 ? 73.309 -62.936  -30.662 1.00 65.99  ? 191 ASP A OD2 1 
ATOM 1470 N N   . ALA A 1 194 ? 67.875 -61.354  -31.415 1.00 73.11  ? 192 ALA A N   1 
ATOM 1471 C CA  . ALA A 1 194 ? 67.003 -60.688  -32.363 1.00 77.91  ? 192 ALA A CA  1 
ATOM 1472 C C   . ALA A 1 194 ? 67.309 -59.191  -32.372 1.00 80.00  ? 192 ALA A C   1 
ATOM 1473 O O   . ALA A 1 194 ? 68.434 -58.791  -32.639 1.00 83.53  ? 192 ALA A O   1 
ATOM 1474 C CB  . ALA A 1 194 ? 65.563 -60.989  -32.011 1.00 89.11  ? 192 ALA A CB  1 
ATOM 1475 N N   . VAL A 1 195 ? 66.312 -58.370  -32.027 1.00 80.75  ? 193 VAL A N   1 
ATOM 1476 C CA  . VAL A 1 195 ? 66.404 -56.927  -32.145 1.00 80.77  ? 193 VAL A CA  1 
ATOM 1477 C C   . VAL A 1 195 ? 66.547 -56.306  -30.759 1.00 83.93  ? 193 VAL A C   1 
ATOM 1478 O O   . VAL A 1 195 ? 66.191 -56.929  -29.758 1.00 78.35  ? 193 VAL A O   1 
ATOM 1479 C CB  . VAL A 1 195 ? 65.149 -56.402  -32.863 1.00 84.36  ? 193 VAL A CB  1 
ATOM 1480 C CG1 . VAL A 1 195 ? 65.092 -56.906  -34.299 1.00 90.60  ? 193 VAL A CG1 1 
ATOM 1481 C CG2 . VAL A 1 195 ? 63.856 -56.738  -32.126 1.00 83.68  ? 193 VAL A CG2 1 
ATOM 1482 N N   . PRO A 1 196 ? 67.086 -55.069  -30.666 1.00 91.70  ? 194 PRO A N   1 
ATOM 1483 C CA  . PRO A 1 196 ? 67.158 -54.357  -29.394 1.00 90.42  ? 194 PRO A CA  1 
ATOM 1484 C C   . PRO A 1 196 ? 65.797 -54.170  -28.733 1.00 86.55  ? 194 PRO A C   1 
ATOM 1485 O O   . PRO A 1 196 ? 64.766 -54.036  -29.404 1.00 77.65  ? 194 PRO A O   1 
ATOM 1486 C CB  . PRO A 1 196 ? 67.814 -53.018  -29.729 1.00 89.91  ? 194 PRO A CB  1 
ATOM 1487 C CG  . PRO A 1 196 ? 68.534 -53.273  -31.029 1.00 100.82 ? 194 PRO A CG  1 
ATOM 1488 C CD  . PRO A 1 196 ? 67.703 -54.313  -31.764 1.00 99.10  ? 194 PRO A CD  1 
ATOM 1489 N N   . ILE A 1 197 ? 65.877 -54.171  -27.398 1.00 81.17  ? 195 ILE A N   1 
ATOM 1490 C CA  . ILE A 1 197 ? 64.781 -53.929  -26.484 1.00 73.42  ? 195 ILE A CA  1 
ATOM 1491 C C   . ILE A 1 197 ? 65.406 -53.339  -25.223 1.00 67.41  ? 195 ILE A C   1 
ATOM 1492 O O   . ILE A 1 197 ? 66.577 -53.579  -24.931 1.00 62.21  ? 195 ILE A O   1 
ATOM 1493 C CB  . ILE A 1 197 ? 64.017 -55.239  -26.199 1.00 70.52  ? 195 ILE A CB  1 
ATOM 1494 C CG1 . ILE A 1 197 ? 62.711 -54.999  -25.447 1.00 62.84  ? 195 ILE A CG1 1 
ATOM 1495 C CG2 . ILE A 1 197 ? 64.900 -56.250  -25.460 1.00 72.59  ? 195 ILE A CG2 1 
ATOM 1496 C CD1 . ILE A 1 197 ? 61.909 -56.268  -25.217 1.00 57.74  ? 195 ILE A CD1 1 
ATOM 1497 N N   . ARG A 1 198 ? 64.633 -52.565  -24.468 1.00 64.77  ? 196 ARG A N   1 
ATOM 1498 C CA  . ARG A 1 198 ? 65.151 -52.034  -23.222 1.00 67.23  ? 196 ARG A CA  1 
ATOM 1499 C C   . ARG A 1 198 ? 64.696 -52.902  -22.053 1.00 61.54  ? 196 ARG A C   1 
ATOM 1500 O O   . ARG A 1 198 ? 63.524 -53.264  -21.947 1.00 56.61  ? 196 ARG A O   1 
ATOM 1501 C CB  . ARG A 1 198 ? 64.672 -50.611  -22.937 1.00 73.94  ? 196 ARG A CB  1 
ATOM 1502 C CG  . ARG A 1 198 ? 64.902 -49.539  -23.990 1.00 70.11  ? 196 ARG A CG  1 
ATOM 1503 C CD  . ARG A 1 198 ? 63.519 -48.982  -24.097 1.00 75.06  ? 196 ARG A CD  1 
ATOM 1504 N NE  . ARG A 1 198 ? 63.365 -47.601  -24.525 1.00 90.28  ? 196 ARG A NE  1 
ATOM 1505 C CZ  . ARG A 1 198 ? 62.201 -46.995  -24.429 1.00 100.39 ? 196 ARG A CZ  1 
ATOM 1506 N NH1 . ARG A 1 198 ? 61.195 -47.604  -23.812 1.00 79.46  ? 196 ARG A NH1 1 
ATOM 1507 N NH2 . ARG A 1 198 ? 62.069 -45.778  -24.937 1.00 129.01 ? 196 ARG A NH2 1 
ATOM 1508 N N   . LEU A 1 199 ? 65.638 -53.167  -21.144 1.00 59.70  ? 197 LEU A N   1 
ATOM 1509 C CA  . LEU A 1 199 ? 65.384 -54.006  -19.989 1.00 58.47  ? 197 LEU A CA  1 
ATOM 1510 C C   . LEU A 1 199 ? 64.076 -53.605  -19.321 1.00 54.41  ? 197 LEU A C   1 
ATOM 1511 O O   . LEU A 1 199 ? 63.305 -54.468  -18.933 1.00 54.89  ? 197 LEU A O   1 
ATOM 1512 C CB  . LEU A 1 199 ? 66.561 -53.887  -19.034 1.00 60.85  ? 197 LEU A CB  1 
ATOM 1513 C CG  . LEU A 1 199 ? 66.528 -54.832  -17.835 1.00 64.74  ? 197 LEU A CG  1 
ATOM 1514 C CD1 . LEU A 1 199 ? 66.634 -56.281  -18.281 1.00 66.49  ? 197 LEU A CD1 1 
ATOM 1515 C CD2 . LEU A 1 199 ? 67.636 -54.468  -16.866 1.00 61.53  ? 197 LEU A CD2 1 
ATOM 1516 N N   . GLY A 1 200 ? 63.831 -52.299  -19.221 1.00 59.05  ? 198 GLY A N   1 
ATOM 1517 C CA  . GLY A 1 200 ? 62.622 -51.765  -18.604 1.00 71.66  ? 198 GLY A CA  1 
ATOM 1518 C C   . GLY A 1 200 ? 61.323 -52.187  -19.304 1.00 76.25  ? 198 GLY A C   1 
ATOM 1519 O O   . GLY A 1 200 ? 60.293 -52.348  -18.639 1.00 77.46  ? 198 GLY A O   1 
ATOM 1520 N N   . GLN A 1 201 ? 61.363 -52.363  -20.635 1.00 75.26  ? 199 GLN A N   1 
ATOM 1521 C CA  . GLN A 1 201 ? 60.208 -52.856  -21.378 1.00 77.46  ? 199 GLN A CA  1 
ATOM 1522 C C   . GLN A 1 201 ? 59.868 -54.284  -20.959 1.00 69.83  ? 199 GLN A C   1 
ATOM 1523 O O   . GLN A 1 201 ? 58.691 -54.648  -20.946 1.00 64.64  ? 199 GLN A O   1 
ATOM 1524 C CB  . GLN A 1 201 ? 60.406 -52.903  -22.894 1.00 75.23  ? 199 GLN A CB  1 
ATOM 1525 C CG  . GLN A 1 201 ? 59.984 -51.640  -23.635 1.00 71.05  ? 199 GLN A CG  1 
ATOM 1526 C CD  . GLN A 1 201 ? 60.877 -51.332  -24.817 1.00 67.21  ? 199 GLN A CD  1 
ATOM 1527 O OE1 . GLN A 1 201 ? 61.986 -51.854  -24.965 1.00 61.46  ? 199 GLN A OE1 1 
ATOM 1528 N NE2 . GLN A 1 201 ? 60.428 -50.405  -25.641 1.00 76.29  ? 199 GLN A NE2 1 
ATOM 1529 N N   . GLU A 1 202 ? 60.906 -55.078  -20.653 1.00 60.31  ? 200 GLU A N   1 
ATOM 1530 C CA  . GLU A 1 202 ? 60.707 -56.436  -20.182 1.00 59.77  ? 200 GLU A CA  1 
ATOM 1531 C C   . GLU A 1 202 ? 60.046 -56.417  -18.812 1.00 60.18  ? 200 GLU A C   1 
ATOM 1532 O O   . GLU A 1 202 ? 59.227 -57.284  -18.507 1.00 63.71  ? 200 GLU A O   1 
ATOM 1533 C CB  . GLU A 1 202 ? 62.004 -57.221  -20.048 1.00 63.55  ? 200 GLU A CB  1 
ATOM 1534 C CG  . GLU A 1 202 ? 62.717 -57.404  -21.380 1.00 74.08  ? 200 GLU A CG  1 
ATOM 1535 C CD  . GLU A 1 202 ? 63.856 -58.392  -21.302 1.00 84.23  ? 200 GLU A CD  1 
ATOM 1536 O OE1 . GLU A 1 202 ? 64.814 -58.153  -20.519 1.00 90.19  ? 200 GLU A OE1 1 
ATOM 1537 O OE2 . GLU A 1 202 ? 63.757 -59.413  -22.018 1.00 93.95  ? 200 GLU A OE2 1 
ATOM 1538 N N   . PHE A 1 203 ? 60.422 -55.443  -17.978 1.00 56.06  ? 201 PHE A N   1 
ATOM 1539 C CA  . PHE A 1 203 ? 59.906 -55.408  -16.621 1.00 55.71  ? 201 PHE A CA  1 
ATOM 1540 C C   . PHE A 1 203 ? 58.502 -54.818  -16.636 1.00 60.83  ? 201 PHE A C   1 
ATOM 1541 O O   . PHE A 1 203 ? 57.696 -55.164  -15.772 1.00 65.52  ? 201 PHE A O   1 
ATOM 1542 C CB  . PHE A 1 203 ? 60.831 -54.691  -15.636 1.00 53.08  ? 201 PHE A CB  1 
ATOM 1543 C CG  . PHE A 1 203 ? 61.896 -55.599  -15.043 1.00 51.50  ? 201 PHE A CG  1 
ATOM 1544 C CD1 . PHE A 1 203 ? 63.015 -55.980  -15.776 1.00 56.10  ? 201 PHE A CD1 1 
ATOM 1545 C CD2 . PHE A 1 203 ? 61.778 -56.075  -13.754 1.00 55.90  ? 201 PHE A CD2 1 
ATOM 1546 C CE1 . PHE A 1 203 ? 63.975 -56.822  -15.236 1.00 55.59  ? 201 PHE A CE1 1 
ATOM 1547 C CE2 . PHE A 1 203 ? 62.750 -56.913  -13.218 1.00 58.57  ? 201 PHE A CE2 1 
ATOM 1548 C CZ  . PHE A 1 203 ? 63.843 -57.284  -13.957 1.00 53.86  ? 201 PHE A CZ  1 
ATOM 1549 N N   . GLU A 1 204 ? 58.188 -53.968  -17.619 1.00 61.53  ? 202 GLU A N   1 
ATOM 1550 C CA  . GLU A 1 204 ? 56.808 -53.513  -17.721 1.00 65.80  ? 202 GLU A CA  1 
ATOM 1551 C C   . GLU A 1 204 ? 55.928 -54.699  -18.114 1.00 59.68  ? 202 GLU A C   1 
ATOM 1552 O O   . GLU A 1 204 ? 54.841 -54.888  -17.589 1.00 53.77  ? 202 GLU A O   1 
ATOM 1553 C CB  . GLU A 1 204 ? 56.518 -52.309  -18.611 1.00 66.67  ? 202 GLU A CB  1 
ATOM 1554 C CG  . GLU A 1 204 ? 55.333 -51.563  -18.006 1.00 71.57  ? 202 GLU A CG  1 
ATOM 1555 C CD  . GLU A 1 204 ? 54.665 -50.500  -18.833 1.00 88.87  ? 202 GLU A CD  1 
ATOM 1556 O OE1 . GLU A 1 204 ? 53.498 -50.258  -18.452 1.00 97.13  ? 202 GLU A OE1 1 
ATOM 1557 O OE2 . GLU A 1 204 ? 55.254 -49.925  -19.783 1.00 102.47 ? 202 GLU A OE2 1 
ATOM 1558 N N   . ALA A 1 205 ? 56.445 -55.547  -18.993 1.00 61.34  ? 203 ALA A N   1 
ATOM 1559 C CA  . ALA A 1 205 ? 55.740 -56.755  -19.373 1.00 63.51  ? 203 ALA A CA  1 
ATOM 1560 C C   . ALA A 1 205 ? 55.409 -57.592  -18.138 1.00 61.57  ? 203 ALA A C   1 
ATOM 1561 O O   . ALA A 1 205 ? 54.278 -58.055  -17.984 1.00 56.92  ? 203 ALA A O   1 
ATOM 1562 C CB  . ALA A 1 205 ? 56.576 -57.529  -20.359 1.00 70.43  ? 203 ALA A CB  1 
ATOM 1563 N N   . TYR A 1 206 ? 56.403 -57.792  -17.269 1.00 59.16  ? 204 TYR A N   1 
ATOM 1564 C CA  . TYR A 1 206 ? 56.154 -58.504  -16.025 1.00 62.10  ? 204 TYR A CA  1 
ATOM 1565 C C   . TYR A 1 206 ? 55.100 -57.746  -15.212 1.00 61.82  ? 204 TYR A C   1 
ATOM 1566 O O   . TYR A 1 206 ? 54.169 -58.358  -14.696 1.00 59.72  ? 204 TYR A O   1 
ATOM 1567 C CB  . TYR A 1 206 ? 57.458 -58.719  -15.257 1.00 59.23  ? 204 TYR A CB  1 
ATOM 1568 C CG  . TYR A 1 206 ? 58.566 -59.400  -16.043 1.00 56.95  ? 204 TYR A CG  1 
ATOM 1569 C CD1 . TYR A 1 206 ? 58.291 -60.272  -17.084 1.00 59.29  ? 204 TYR A CD1 1 
ATOM 1570 C CD2 . TYR A 1 206 ? 59.901 -59.165  -15.735 1.00 62.99  ? 204 TYR A CD2 1 
ATOM 1571 C CE1 . TYR A 1 206 ? 59.308 -60.902  -17.787 1.00 66.68  ? 204 TYR A CE1 1 
ATOM 1572 C CE2 . TYR A 1 206 ? 60.930 -59.786  -16.425 1.00 66.13  ? 204 TYR A CE2 1 
ATOM 1573 C CZ  . TYR A 1 206 ? 60.632 -60.671  -17.450 1.00 69.94  ? 204 TYR A CZ  1 
ATOM 1574 O OH  . TYR A 1 206 ? 61.633 -61.300  -18.139 1.00 63.42  ? 204 TYR A OH  1 
ATOM 1575 N N   . THR A 1 207 ? 55.210 -56.411  -15.144 1.00 58.46  ? 205 THR A N   1 
ATOM 1576 C CA  . THR A 1 207 ? 54.324 -55.615  -14.300 1.00 59.60  ? 205 THR A CA  1 
ATOM 1577 C C   . THR A 1 207 ? 52.860 -55.809  -14.691 1.00 59.36  ? 205 THR A C   1 
ATOM 1578 O O   . THR A 1 207 ? 51.988 -55.819  -13.829 1.00 57.25  ? 205 THR A O   1 
ATOM 1579 C CB  . THR A 1 207 ? 54.701 -54.136  -14.375 1.00 58.84  ? 205 THR A CB  1 
ATOM 1580 O OG1 . THR A 1 207 ? 56.015 -54.096  -13.836 1.00 61.35  ? 205 THR A OG1 1 
ATOM 1581 C CG2 . THR A 1 207 ? 53.775 -53.225  -13.588 1.00 54.10  ? 205 THR A CG2 1 
ATOM 1582 N N   . ARG A 1 208 ? 52.597 -55.940  -15.992 1.00 60.73  ? 206 ARG A N   1 
ATOM 1583 C CA  . ARG A 1 208 ? 51.237 -55.882  -16.491 1.00 65.49  ? 206 ARG A CA  1 
ATOM 1584 C C   . ARG A 1 208 ? 50.577 -57.252  -16.375 1.00 68.32  ? 206 ARG A C   1 
ATOM 1585 O O   . ARG A 1 208 ? 49.394 -57.337  -16.063 1.00 67.40  ? 206 ARG A O   1 
ATOM 1586 C CB  . ARG A 1 208 ? 51.273 -55.290  -17.900 1.00 69.64  ? 206 ARG A CB  1 
ATOM 1587 C CG  . ARG A 1 208 ? 51.838 -53.881  -17.842 1.00 71.07  ? 206 ARG A CG  1 
ATOM 1588 C CD  . ARG A 1 208 ? 51.974 -53.249  -19.197 1.00 69.12  ? 206 ARG A CD  1 
ATOM 1589 N NE  . ARG A 1 208 ? 50.722 -52.579  -19.541 1.00 69.32  ? 206 ARG A NE  1 
ATOM 1590 C CZ  . ARG A 1 208 ? 49.839 -53.002  -20.440 1.00 85.67  ? 206 ARG A CZ  1 
ATOM 1591 N NH1 . ARG A 1 208 ? 49.974 -54.190  -21.009 1.00 81.59  ? 206 ARG A NH1 1 
ATOM 1592 N NH2 . ARG A 1 208 ? 48.795 -52.240  -20.737 1.00 101.35 ? 206 ARG A NH2 1 
ATOM 1593 N N   . VAL A 1 209 ? 51.338 -58.328  -16.602 1.00 69.48  ? 207 VAL A N   1 
ATOM 1594 C CA  . VAL A 1 209 ? 50.799 -59.667  -16.430 1.00 68.74  ? 207 VAL A CA  1 
ATOM 1595 C C   . VAL A 1 209 ? 50.334 -59.797  -14.982 1.00 70.78  ? 207 VAL A C   1 
ATOM 1596 O O   . VAL A 1 209 ? 49.314 -60.424  -14.698 1.00 74.41  ? 207 VAL A O   1 
ATOM 1597 C CB  . VAL A 1 209 ? 51.822 -60.751  -16.835 1.00 68.98  ? 207 VAL A CB  1 
ATOM 1598 C CG1 . VAL A 1 209 ? 52.976 -60.862  -15.856 1.00 69.25  ? 207 VAL A CG1 1 
ATOM 1599 C CG2 . VAL A 1 209 ? 51.189 -62.120  -17.033 1.00 68.55  ? 207 VAL A CG2 1 
ATOM 1600 N N   . ILE A 1 210 ? 51.073 -59.157  -14.071 1.00 72.14  ? 208 ILE A N   1 
ATOM 1601 C CA  . ILE A 1 210 ? 50.739 -59.200  -12.660 1.00 66.92  ? 208 ILE A CA  1 
ATOM 1602 C C   . ILE A 1 210 ? 49.496 -58.355  -12.412 1.00 58.66  ? 208 ILE A C   1 
ATOM 1603 O O   . ILE A 1 210 ? 48.609 -58.778  -11.684 1.00 58.28  ? 208 ILE A O   1 
ATOM 1604 C CB  . ILE A 1 210 ? 51.938 -58.781  -11.796 1.00 64.85  ? 208 ILE A CB  1 
ATOM 1605 C CG1 . ILE A 1 210 ? 53.101 -59.761  -11.964 1.00 66.73  ? 208 ILE A CG1 1 
ATOM 1606 C CG2 . ILE A 1 210 ? 51.518 -58.679  -10.337 1.00 66.76  ? 208 ILE A CG2 1 
ATOM 1607 C CD1 . ILE A 1 210 ? 54.448 -59.208  -11.531 1.00 63.44  ? 208 ILE A CD1 1 
ATOM 1608 N N   . GLU A 1 211 ? 49.418 -57.180  -13.037 1.00 57.81  ? 209 GLU A N   1 
ATOM 1609 C CA  . GLU A 1 211 ? 48.216 -56.368  -12.946 1.00 66.67  ? 209 GLU A CA  1 
ATOM 1610 C C   . GLU A 1 211 ? 47.009 -57.255  -13.258 1.00 66.47  ? 209 GLU A C   1 
ATOM 1611 O O   . GLU A 1 211 ? 46.010 -57.221  -12.542 1.00 67.96  ? 209 GLU A O   1 
ATOM 1612 C CB  . GLU A 1 211 ? 48.301 -55.125  -13.841 1.00 74.58  ? 209 GLU A CB  1 
ATOM 1613 C CG  . GLU A 1 211 ? 49.217 -54.025  -13.297 1.00 77.36  ? 209 GLU A CG  1 
ATOM 1614 C CD  . GLU A 1 211 ? 49.430 -52.793  -14.176 1.00 80.00  ? 209 GLU A CD  1 
ATOM 1615 O OE1 . GLU A 1 211 ? 48.625 -52.572  -15.097 1.00 88.41  ? 209 GLU A OE1 1 
ATOM 1616 O OE2 . GLU A 1 211 ? 50.401 -52.034  -13.968 1.00 80.85  ? 209 GLU A OE2 1 
ATOM 1617 N N   . ARG A 1 212 ? 47.133 -58.080  -14.306 1.00 69.23  ? 210 ARG A N   1 
ATOM 1618 C CA  . ARG A 1 212 ? 46.035 -58.908  -14.790 1.00 72.30  ? 210 ARG A CA  1 
ATOM 1619 C C   . ARG A 1 212 ? 45.751 -60.044  -13.811 1.00 73.08  ? 210 ARG A C   1 
ATOM 1620 O O   . ARG A 1 212 ? 44.590 -60.377  -13.571 1.00 70.02  ? 210 ARG A O   1 
ATOM 1621 C CB  . ARG A 1 212 ? 46.306 -59.452  -16.201 1.00 67.55  ? 210 ARG A CB  1 
ATOM 1622 C CG  . ARG A 1 212 ? 46.070 -58.434  -17.310 1.00 61.66  ? 210 ARG A CG  1 
ATOM 1623 C CD  . ARG A 1 212 ? 46.041 -59.043  -18.697 1.00 56.17  ? 210 ARG A CD  1 
ATOM 1624 N NE  . ARG A 1 212 ? 47.303 -59.683  -19.092 1.00 54.75  ? 210 ARG A NE  1 
ATOM 1625 C CZ  . ARG A 1 212 ? 48.434 -59.071  -19.438 1.00 52.58  ? 210 ARG A CZ  1 
ATOM 1626 N NH1 . ARG A 1 212 ? 48.527 -57.752  -19.425 1.00 56.76  ? 210 ARG A NH1 1 
ATOM 1627 N NH2 . ARG A 1 212 ? 49.481 -59.781  -19.810 1.00 48.64  ? 210 ARG A NH2 1 
ATOM 1628 N N   . ASP A 1 213 ? 46.807 -60.643  -13.254 1.00 68.98  ? 211 ASP A N   1 
ATOM 1629 C CA  . ASP A 1 213 ? 46.622 -61.685  -12.264 1.00 70.72  ? 211 ASP A CA  1 
ATOM 1630 C C   . ASP A 1 213 ? 45.785 -61.153  -11.102 1.00 65.67  ? 211 ASP A C   1 
ATOM 1631 O O   . ASP A 1 213 ? 44.905 -61.840  -10.581 1.00 65.43  ? 211 ASP A O   1 
ATOM 1632 C CB  . ASP A 1 213 ? 47.954 -62.249  -11.807 1.00 80.38  ? 211 ASP A CB  1 
ATOM 1633 C CG  . ASP A 1 213 ? 48.601 -63.210  -12.791 1.00 84.73  ? 211 ASP A CG  1 
ATOM 1634 O OD1 . ASP A 1 213 ? 47.835 -64.008  -13.394 1.00 91.59  ? 211 ASP A OD1 1 
ATOM 1635 O OD2 . ASP A 1 213 ? 49.858 -63.181  -12.906 1.00 75.92  ? 211 ASP A OD2 1 
ATOM 1636 N N   . ILE A 1 214 ? 46.061 -59.915  -10.696 1.00 61.43  ? 212 ILE A N   1 
ATOM 1637 C CA  . ILE A 1 214 ? 45.364 -59.322  -9.570  1.00 61.82  ? 212 ILE A CA  1 
ATOM 1638 C C   . ILE A 1 214 ? 43.876 -59.246  -9.882  1.00 58.14  ? 212 ILE A C   1 
ATOM 1639 O O   . ILE A 1 214 ? 43.065 -59.598  -9.033  1.00 50.42  ? 212 ILE A O   1 
ATOM 1640 C CB  . ILE A 1 214 ? 45.967 -57.955  -9.203  1.00 66.02  ? 212 ILE A CB  1 
ATOM 1641 C CG1 . ILE A 1 214 ? 47.327 -58.144  -8.521  1.00 65.07  ? 212 ILE A CG1 1 
ATOM 1642 C CG2 . ILE A 1 214 ? 45.000 -57.141  -8.338  1.00 72.86  ? 212 ILE A CG2 1 
ATOM 1643 C CD1 . ILE A 1 214 ? 48.122 -56.867  -8.331  1.00 63.88  ? 212 ILE A CD1 1 
ATOM 1644 N N   . GLN A 1 215 ? 43.539 -58.792  -11.096 1.00 65.50  ? 213 GLN A N   1 
ATOM 1645 C CA  . GLN A 1 215 ? 42.153 -58.601  -11.495 1.00 69.10  ? 213 GLN A CA  1 
ATOM 1646 C C   . GLN A 1 215 ? 41.413 -59.935  -11.537 1.00 61.17  ? 213 GLN A C   1 
ATOM 1647 O O   . GLN A 1 215 ? 40.251 -59.993  -11.144 1.00 66.08  ? 213 GLN A O   1 
ATOM 1648 C CB  . GLN A 1 215 ? 42.030 -57.912  -12.848 1.00 78.41  ? 213 GLN A CB  1 
ATOM 1649 C CG  . GLN A 1 215 ? 42.349 -56.421  -12.807 1.00 91.37  ? 213 GLN A CG  1 
ATOM 1650 C CD  . GLN A 1 215 ? 42.566 -55.847  -14.193 1.00 110.19 ? 213 GLN A CD  1 
ATOM 1651 O OE1 . GLN A 1 215 ? 42.675 -56.581  -15.187 1.00 107.65 ? 213 GLN A OE1 1 
ATOM 1652 N NE2 . GLN A 1 215 ? 42.620 -54.523  -14.278 1.00 110.92 ? 213 GLN A NE2 1 
ATOM 1653 N N   . ARG A 1 216 ? 42.083 -60.992  -12.006 1.00 53.55  ? 214 ARG A N   1 
ATOM 1654 C CA  . ARG A 1 216 ? 41.475 -62.313  -12.078 1.00 56.83  ? 214 ARG A CA  1 
ATOM 1655 C C   . ARG A 1 216 ? 41.219 -62.882  -10.680 1.00 60.70  ? 214 ARG A C   1 
ATOM 1656 O O   . ARG A 1 216 ? 40.201 -63.538  -10.438 1.00 69.67  ? 214 ARG A O   1 
ATOM 1657 C CB  . ARG A 1 216 ? 42.362 -63.311  -12.828 1.00 64.92  ? 214 ARG A CB  1 
ATOM 1658 C CG  . ARG A 1 216 ? 42.193 -63.359  -14.335 1.00 67.73  ? 214 ARG A CG  1 
ATOM 1659 C CD  . ARG A 1 216 ? 43.103 -64.413  -14.937 1.00 71.83  ? 214 ARG A CD  1 
ATOM 1660 N NE  . ARG A 1 216 ? 44.502 -63.974  -14.966 1.00 77.06  ? 214 ARG A NE  1 
ATOM 1661 C CZ  . ARG A 1 216 ? 45.117 -63.517  -16.061 1.00 77.92  ? 214 ARG A CZ  1 
ATOM 1662 N NH1 . ARG A 1 216 ? 44.421 -63.249  -17.159 1.00 73.09  ? 214 ARG A NH1 1 
ATOM 1663 N NH2 . ARG A 1 216 ? 46.424 -63.312  -16.047 1.00 73.53  ? 214 ARG A NH2 1 
ATOM 1664 N N   . ILE A 1 217 ? 42.169 -62.673  -9.762  1.00 53.32  ? 215 ILE A N   1 
ATOM 1665 C CA  . ILE A 1 217 ? 42.035 -63.230  -8.434  1.00 46.88  ? 215 ILE A CA  1 
ATOM 1666 C C   . ILE A 1 217 ? 40.979 -62.430  -7.685  1.00 47.73  ? 215 ILE A C   1 
ATOM 1667 O O   . ILE A 1 217 ? 40.147 -63.000  -6.997  1.00 54.31  ? 215 ILE A O   1 
ATOM 1668 C CB  . ILE A 1 217 ? 43.404 -63.281  -7.748  1.00 42.97  ? 215 ILE A CB  1 
ATOM 1669 C CG1 . ILE A 1 217 ? 44.296 -64.262  -8.479  1.00 43.97  ? 215 ILE A CG1 1 
ATOM 1670 C CG2 . ILE A 1 217 ? 43.268 -63.642  -6.270  1.00 43.31  ? 215 ILE A CG2 1 
ATOM 1671 C CD1 . ILE A 1 217 ? 45.770 -64.185  -8.122  1.00 46.55  ? 215 ILE A CD1 1 
ATOM 1672 N N   . LYS A 1 218 ? 41.000 -61.111  -7.851  1.00 56.05  ? 216 LYS A N   1 
ATOM 1673 C CA  . LYS A 1 218 ? 39.948 -60.260  -7.315  1.00 67.34  ? 216 LYS A CA  1 
ATOM 1674 C C   . LYS A 1 218 ? 38.589 -60.836  -7.701  1.00 67.31  ? 216 LYS A C   1 
ATOM 1675 O O   . LYS A 1 218 ? 37.763 -61.089  -6.825  1.00 82.37  ? 216 LYS A O   1 
ATOM 1676 C CB  . LYS A 1 218 ? 40.058 -58.785  -7.732  1.00 72.55  ? 216 LYS A CB  1 
ATOM 1677 C CG  . LYS A 1 218 ? 40.684 -57.867  -6.684  1.00 75.52  ? 216 LYS A CG  1 
ATOM 1678 C CD  . LYS A 1 218 ? 40.845 -56.416  -7.115  1.00 84.23  ? 216 LYS A CD  1 
ATOM 1679 C CE  . LYS A 1 218 ? 41.784 -55.666  -6.206  1.00 97.80  ? 216 LYS A CE  1 
ATOM 1680 N NZ  . LYS A 1 218 ? 42.081 -54.308  -6.667  1.00 103.31 ? 216 LYS A NZ  1 
ATOM 1681 N N   . GLN A 1 219 ? 38.375 -61.075  -9.000  1.00 57.22  ? 217 GLN A N   1 
ATOM 1682 C CA  . GLN A 1 219 ? 37.071 -61.514  -9.467  1.00 62.73  ? 217 GLN A CA  1 
ATOM 1683 C C   . GLN A 1 219 ? 36.693 -62.882  -8.901  1.00 68.72  ? 217 GLN A C   1 
ATOM 1684 O O   . GLN A 1 219 ? 35.509 -63.152  -8.699  1.00 69.08  ? 217 GLN A O   1 
ATOM 1685 C CB  . GLN A 1 219 ? 36.989 -61.608  -10.983 1.00 65.96  ? 217 GLN A CB  1 
ATOM 1686 C CG  . GLN A 1 219 ? 36.632 -60.294  -11.658 1.00 78.65  ? 217 GLN A CG  1 
ATOM 1687 C CD  . GLN A 1 219 ? 36.763 -60.399  -13.161 1.00 97.51  ? 217 GLN A CD  1 
ATOM 1688 O OE1 . GLN A 1 219 ? 35.803 -60.785  -13.833 1.00 117.70 ? 217 GLN A OE1 1 
ATOM 1689 N NE2 . GLN A 1 219 ? 37.951 -60.137  -13.704 1.00 94.59  ? 217 GLN A NE2 1 
ATOM 1690 N N   . SER A 1 220 ? 37.680 -63.754  -8.650  1.00 67.86  ? 218 SER A N   1 
ATOM 1691 C CA  . SER A 1 220 ? 37.376 -65.120  -8.238  1.00 69.39  ? 218 SER A CA  1 
ATOM 1692 C C   . SER A 1 220 ? 36.546 -65.134  -6.951  1.00 72.12  ? 218 SER A C   1 
ATOM 1693 O O   . SER A 1 220 ? 35.820 -66.100  -6.682  1.00 78.21  ? 218 SER A O   1 
ATOM 1694 C CB  . SER A 1 220 ? 38.628 -65.945  -8.097  1.00 65.40  ? 218 SER A CB  1 
ATOM 1695 O OG  . SER A 1 220 ? 39.565 -65.320  -7.236  1.00 70.48  ? 218 SER A OG  1 
ATOM 1696 N N   . ARG A 1 221 ? 36.656 -64.029  -6.198  1.00 64.61  ? 219 ARG A N   1 
ATOM 1697 C CA  . ARG A 1 221 ? 36.021 -63.848  -4.906  1.00 68.45  ? 219 ARG A CA  1 
ATOM 1698 C C   . ARG A 1 221 ? 34.504 -63.712  -5.002  1.00 63.97  ? 219 ARG A C   1 
ATOM 1699 O O   . ARG A 1 221 ? 33.797 -64.068  -4.061  1.00 65.86  ? 219 ARG A O   1 
ATOM 1700 C CB  . ARG A 1 221 ? 36.486 -62.538  -4.264  1.00 74.06  ? 219 ARG A CB  1 
ATOM 1701 C CG  . ARG A 1 221 ? 37.964 -62.457  -3.918  1.00 73.33  ? 219 ARG A CG  1 
ATOM 1702 C CD  . ARG A 1 221 ? 38.219 -61.271  -3.009  1.00 75.47  ? 219 ARG A CD  1 
ATOM 1703 N NE  . ARG A 1 221 ? 38.015 -60.020  -3.743  1.00 76.68  ? 219 ARG A NE  1 
ATOM 1704 C CZ  . ARG A 1 221 ? 38.306 -58.823  -3.264  1.00 84.82  ? 219 ARG A CZ  1 
ATOM 1705 N NH1 . ARG A 1 221 ? 38.839 -58.703  -2.063  1.00 92.05  ? 219 ARG A NH1 1 
ATOM 1706 N NH2 . ARG A 1 221 ? 38.070 -57.745  -3.988  1.00 91.03  ? 219 ARG A NH2 1 
ATOM 1707 N N   . GLY A 1 222 ? 34.017 -63.124  -6.095  1.00 59.99  ? 220 GLY A N   1 
ATOM 1708 C CA  . GLY A 1 222 ? 32.608 -62.784  -6.205  1.00 62.27  ? 220 GLY A CA  1 
ATOM 1709 C C   . GLY A 1 222 ? 31.710 -63.926  -5.740  1.00 60.58  ? 220 GLY A C   1 
ATOM 1710 O O   . GLY A 1 222 ? 30.827 -63.733  -4.907  1.00 62.84  ? 220 GLY A O   1 
ATOM 1711 N N   . HIS A 1 223 ? 31.974 -65.124  -6.270  1.00 62.79  ? 221 HIS A N   1 
ATOM 1712 C CA  . HIS A 1 223 ? 31.116 -66.275  -6.037  1.00 66.05  ? 221 HIS A CA  1 
ATOM 1713 C C   . HIS A 1 223 ? 31.219 -66.741  -4.585  1.00 68.43  ? 221 HIS A C   1 
ATOM 1714 O O   . HIS A 1 223 ? 30.314 -67.400  -4.103  1.00 77.57  ? 221 HIS A O   1 
ATOM 1715 C CB  . HIS A 1 223 ? 31.378 -67.357  -7.097  1.00 72.15  ? 221 HIS A CB  1 
ATOM 1716 C CG  . HIS A 1 223 ? 30.768 -67.035  -8.434  1.00 80.99  ? 221 HIS A CG  1 
ATOM 1717 N ND1 . HIS A 1 223 ? 29.543 -66.398  -8.556  1.00 83.10  ? 221 HIS A ND1 1 
ATOM 1718 C CD2 . HIS A 1 223 ? 31.201 -67.242  -9.691  1.00 74.82  ? 221 HIS A CD2 1 
ATOM 1719 C CE1 . HIS A 1 223 ? 29.251 -66.228  -9.835  1.00 77.15  ? 221 HIS A CE1 1 
ATOM 1720 N NE2 . HIS A 1 223 ? 30.235 -66.745  -10.541 1.00 79.11  ? 221 HIS A NE2 1 
ATOM 1721 N N   . LEU A 1 224 ? 32.295 -66.372  -3.878  1.00 71.44  ? 222 LEU A N   1 
ATOM 1722 C CA  . LEU A 1 224 ? 32.525 -66.802  -2.503  1.00 66.76  ? 222 LEU A CA  1 
ATOM 1723 C C   . LEU A 1 224 ? 31.636 -66.041  -1.525  1.00 69.96  ? 222 LEU A C   1 
ATOM 1724 O O   . LEU A 1 224 ? 31.373 -66.558  -0.437  1.00 71.21  ? 222 LEU A O   1 
ATOM 1725 C CB  . LEU A 1 224 ? 33.992 -66.604  -2.123  1.00 64.10  ? 222 LEU A CB  1 
ATOM 1726 C CG  . LEU A 1 224 ? 34.991 -67.523  -2.827  1.00 61.79  ? 222 LEU A CG  1 
ATOM 1727 C CD1 . LEU A 1 224 ? 36.401 -67.086  -2.496  1.00 60.91  ? 222 LEU A CD1 1 
ATOM 1728 C CD2 . LEU A 1 224 ? 34.756 -68.977  -2.437  1.00 58.94  ? 222 LEU A CD2 1 
ATOM 1729 N N   . TYR A 1 225 ? 31.235 -64.811  -1.900  1.00 66.78  ? 223 TYR A N   1 
ATOM 1730 C CA  . TYR A 1 225 ? 30.444 -63.937  -1.042  1.00 59.68  ? 223 TYR A CA  1 
ATOM 1731 C C   . TYR A 1 225 ? 29.087 -64.578  -0.779  1.00 57.97  ? 223 TYR A C   1 
ATOM 1732 O O   . TYR A 1 225 ? 28.513 -64.339  0.281   1.00 56.53  ? 223 TYR A O   1 
ATOM 1733 C CB  . TYR A 1 225 ? 30.249 -62.529  -1.618  1.00 57.08  ? 223 TYR A CB  1 
ATOM 1734 C CG  . TYR A 1 225 ? 31.508 -61.683  -1.693  1.00 57.77  ? 223 TYR A CG  1 
ATOM 1735 C CD1 . TYR A 1 225 ? 32.307 -61.499  -0.581  1.00 64.94  ? 223 TYR A CD1 1 
ATOM 1736 C CD2 . TYR A 1 225 ? 31.934 -61.116  -2.884  1.00 67.72  ? 223 TYR A CD2 1 
ATOM 1737 C CE1 . TYR A 1 225 ? 33.475 -60.753  -0.637  1.00 68.31  ? 223 TYR A CE1 1 
ATOM 1738 C CE2 . TYR A 1 225 ? 33.096 -60.358  -2.953  1.00 69.17  ? 223 TYR A CE2 1 
ATOM 1739 C CZ  . TYR A 1 225 ? 33.878 -60.184  -1.826  1.00 64.62  ? 223 TYR A CZ  1 
ATOM 1740 O OH  . TYR A 1 225 ? 35.032 -59.460  -1.841  1.00 64.66  ? 223 TYR A OH  1 
ATOM 1741 N N   . GLU A 1 226 ? 28.596 -65.382  -1.736  1.00 61.69  ? 224 GLU A N   1 
ATOM 1742 C CA  . GLU A 1 226 ? 27.377 -66.162  -1.556  1.00 72.01  ? 224 GLU A CA  1 
ATOM 1743 C C   . GLU A 1 226 ? 27.662 -67.332  -0.615  1.00 65.10  ? 224 GLU A C   1 
ATOM 1744 O O   . GLU A 1 226 ? 28.605 -68.086  -0.848  1.00 66.01  ? 224 GLU A O   1 
ATOM 1745 C CB  . GLU A 1 226 ? 26.858 -66.692  -2.898  1.00 81.10  ? 224 GLU A CB  1 
ATOM 1746 C CG  . GLU A 1 226 ? 26.168 -65.654  -3.784  1.00 87.73  ? 224 GLU A CG  1 
ATOM 1747 C CD  . GLU A 1 226 ? 26.593 -65.597  -5.251  1.00 93.22  ? 224 GLU A CD  1 
ATOM 1748 O OE1 . GLU A 1 226 ? 27.600 -64.894  -5.523  1.00 86.16  ? 224 GLU A OE1 1 
ATOM 1749 O OE2 . GLU A 1 226 ? 25.946 -66.243  -6.116  1.00 100.13 ? 224 GLU A OE2 1 
ATOM 1750 N N   . ILE A 1 227 ? 26.845 -67.474  0.439   1.00 55.93  ? 225 ILE A N   1 
ATOM 1751 C CA  . ILE A 1 227 ? 27.070 -68.499  1.440   1.00 63.01  ? 225 ILE A CA  1 
ATOM 1752 C C   . ILE A 1 227 ? 25.766 -69.246  1.682   1.00 63.21  ? 225 ILE A C   1 
ATOM 1753 O O   . ILE A 1 227 ? 24.690 -68.667  1.602   1.00 74.81  ? 225 ILE A O   1 
ATOM 1754 C CB  . ILE A 1 227 ? 27.635 -67.896  2.739   1.00 71.31  ? 225 ILE A CB  1 
ATOM 1755 C CG1 . ILE A 1 227 ? 26.817 -66.711  3.227   1.00 73.66  ? 225 ILE A CG1 1 
ATOM 1756 C CG2 . ILE A 1 227 ? 29.104 -67.516  2.579   1.00 69.71  ? 225 ILE A CG2 1 
ATOM 1757 C CD1 . ILE A 1 227 ? 27.065 -66.393  4.689   1.00 77.10  ? 225 ILE A CD1 1 
ATOM 1758 N N   . ASN A 1 228 ? 25.882 -70.531  2.025   1.00 61.64  ? 226 ASN A N   1 
ATOM 1759 C CA  . ASN A 1 228 ? 24.763 -71.455  1.942   1.00 65.98  ? 226 ASN A CA  1 
ATOM 1760 C C   . ASN A 1 228 ? 24.172 -71.686  3.320   1.00 69.08  ? 226 ASN A C   1 
ATOM 1761 O O   . ASN A 1 228 ? 23.532 -72.706  3.552   1.00 73.37  ? 226 ASN A O   1 
ATOM 1762 C CB  . ASN A 1 228 ? 25.188 -72.797  1.352   1.00 74.55  ? 226 ASN A CB  1 
ATOM 1763 C CG  . ASN A 1 228 ? 25.930 -73.669  2.341   1.00 73.83  ? 226 ASN A CG  1 
ATOM 1764 O OD1 . ASN A 1 228 ? 26.792 -73.184  3.078   1.00 78.58  ? 226 ASN A OD1 1 
ATOM 1765 N ND2 . ASN A 1 228 ? 25.611 -74.953  2.379   1.00 70.66  ? 226 ASN A ND2 1 
ATOM 1766 N N   . MET A 1 229 ? 24.390 -70.733  4.227   1.00 76.98  ? 227 MET A N   1 
ATOM 1767 C CA  . MET A 1 229 ? 24.062 -70.930  5.630   1.00 79.34  ? 227 MET A CA  1 
ATOM 1768 C C   . MET A 1 229 ? 22.551 -71.128  5.786   1.00 66.00  ? 227 MET A C   1 
ATOM 1769 O O   . MET A 1 229 ? 21.750 -70.330  5.308   1.00 43.67  ? 227 MET A O   1 
ATOM 1770 C CB  . MET A 1 229 ? 24.567 -69.747  6.464   1.00 85.65  ? 227 MET A CB  1 
ATOM 1771 C CG  . MET A 1 229 ? 24.825 -70.099  7.909   1.00 88.00  ? 227 MET A CG  1 
ATOM 1772 S SD  . MET A 1 229 ? 26.263 -71.163  8.125   1.00 89.02  ? 227 MET A SD  1 
ATOM 1773 C CE  . MET A 1 229 ? 25.820 -71.820  9.737   1.00 95.26  ? 227 MET A CE  1 
ATOM 1774 N N   . GLY A 1 230 ? 22.175 -72.225  6.449   1.00 76.64  ? 228 GLY A N   1 
ATOM 1775 C CA  . GLY A 1 230 ? 20.774 -72.583  6.620   1.00 83.75  ? 228 GLY A CA  1 
ATOM 1776 C C   . GLY A 1 230 ? 20.291 -73.525  5.521   1.00 76.33  ? 228 GLY A C   1 
ATOM 1777 O O   . GLY A 1 230 ? 19.096 -73.716  5.337   1.00 67.59  ? 228 GLY A O   1 
ATOM 1778 N N   . ALA A 1 231 ? 21.242 -74.104  4.791   1.00 79.58  ? 229 ALA A N   1 
ATOM 1779 C CA  . ALA A 1 231 ? 20.937 -75.120  3.802   1.00 80.10  ? 229 ALA A CA  1 
ATOM 1780 C C   . ALA A 1 231 ? 20.656 -76.433  4.507   1.00 72.58  ? 229 ALA A C   1 
ATOM 1781 O O   . ALA A 1 231 ? 19.933 -77.276  3.989   1.00 69.17  ? 229 ALA A O   1 
ATOM 1782 C CB  . ALA A 1 231 ? 22.094 -75.269  2.849   1.00 88.93  ? 229 ALA A CB  1 
ATOM 1783 N N   . THR A 1 232 ? 21.267 -76.586  5.683   1.00 81.99  ? 230 THR A N   1 
ATOM 1784 C CA  . THR A 1 232 ? 21.149 -77.805  6.459   1.00 94.31  ? 230 THR A CA  1 
ATOM 1785 C C   . THR A 1 232 ? 21.710 -78.961  5.624   1.00 94.53  ? 230 THR A C   1 
ATOM 1786 O O   . THR A 1 232 ? 22.797 -78.829  5.048   1.00 87.42  ? 230 THR A O   1 
ATOM 1787 C CB  . THR A 1 232 ? 19.696 -77.976  6.915   1.00 85.39  ? 230 THR A CB  1 
ATOM 1788 O OG1 . THR A 1 232 ? 18.907 -78.477  5.845   1.00 90.99  ? 230 THR A OG1 1 
ATOM 1789 C CG2 . THR A 1 232 ? 19.083 -76.669  7.382   1.00 79.97  ? 230 THR A CG2 1 
ATOM 1790 N N   . ALA A 1 233 ? 20.962 -80.074  5.544   1.00 88.70  ? 231 ALA A N   1 
ATOM 1791 C CA  . ALA A 1 233 ? 21.478 -81.330  5.016   1.00 88.40  ? 231 ALA A CA  1 
ATOM 1792 C C   . ALA A 1 233 ? 21.831 -81.216  3.531   1.00 93.10  ? 231 ALA A C   1 
ATOM 1793 O O   . ALA A 1 233 ? 22.955 -81.528  3.135   1.00 82.14  ? 231 ALA A O   1 
ATOM 1794 C CB  . ALA A 1 233 ? 20.474 -82.445  5.242   1.00 81.31  ? 231 ALA A CB  1 
ATOM 1795 N N   . VAL A 1 234 ? 20.871 -80.736  2.726   1.00 88.57  ? 232 VAL A N   1 
ATOM 1796 C CA  . VAL A 1 234 ? 20.844 -80.999  1.296   1.00 74.37  ? 232 VAL A CA  1 
ATOM 1797 C C   . VAL A 1 234 ? 20.714 -79.728  0.449   1.00 71.63  ? 232 VAL A C   1 
ATOM 1798 O O   . VAL A 1 234 ? 21.111 -79.716  -0.727  1.00 77.66  ? 232 VAL A O   1 
ATOM 1799 C CB  . VAL A 1 234 ? 19.661 -81.973  1.154   1.00 69.01  ? 232 VAL A CB  1 
ATOM 1800 C CG1 . VAL A 1 234 ? 18.933 -81.856  -0.178  1.00 69.36  ? 232 VAL A CG1 1 
ATOM 1801 C CG2 . VAL A 1 234 ? 20.116 -83.402  1.428   1.00 69.35  ? 232 VAL A CG2 1 
ATOM 1802 N N   . GLY A 1 235 ? 20.173 -78.660  1.049   1.00 66.04  ? 233 GLY A N   1 
ATOM 1803 C CA  . GLY A 1 235 ? 19.903 -77.423  0.340   1.00 68.13  ? 233 GLY A CA  1 
ATOM 1804 C C   . GLY A 1 235 ? 18.445 -77.006  0.501   1.00 81.63  ? 233 GLY A C   1 
ATOM 1805 O O   . GLY A 1 235 ? 18.138 -75.827  0.334   1.00 96.44  ? 233 GLY A O   1 
ATOM 1806 N N   . THR A 1 236 ? 17.568 -77.974  0.831   1.00 78.72  ? 234 THR A N   1 
ATOM 1807 C CA  . THR A 1 236 ? 16.145 -77.708  1.004   1.00 71.31  ? 234 THR A CA  1 
ATOM 1808 C C   . THR A 1 236 ? 15.921 -76.778  2.199   1.00 70.42  ? 234 THR A C   1 
ATOM 1809 O O   . THR A 1 236 ? 14.921 -76.066  2.252   1.00 68.06  ? 234 THR A O   1 
ATOM 1810 C CB  . THR A 1 236 ? 15.348 -79.011  1.127   1.00 75.96  ? 234 THR A CB  1 
ATOM 1811 O OG1 . THR A 1 236 ? 15.666 -79.787  2.281   1.00 69.62  ? 234 THR A OG1 1 
ATOM 1812 C CG2 . THR A 1 236 ? 15.533 -79.898  -0.093  1.00 79.28  ? 234 THR A CG2 1 
ATOM 1813 N N   . GLY A 1 237 ? 16.868 -76.774  3.147   1.00 76.76  ? 235 GLY A N   1 
ATOM 1814 C CA  . GLY A 1 237 ? 16.852 -75.814  4.240   1.00 81.54  ? 235 GLY A CA  1 
ATOM 1815 C C   . GLY A 1 237 ? 15.814 -76.182  5.291   1.00 82.90  ? 235 GLY A C   1 
ATOM 1816 O O   . GLY A 1 237 ? 15.359 -75.301  6.013   1.00 93.78  ? 235 GLY A O   1 
ATOM 1817 N N   . LEU A 1 238 ? 15.475 -77.474  5.359   1.00 81.03  ? 236 LEU A N   1 
ATOM 1818 C CA  . LEU A 1 238 ? 14.343 -77.953  6.131   1.00 81.79  ? 236 LEU A CA  1 
ATOM 1819 C C   . LEU A 1 238 ? 14.684 -77.880  7.609   1.00 82.45  ? 236 LEU A C   1 
ATOM 1820 O O   . LEU A 1 238 ? 15.770 -78.301  7.982   1.00 84.07  ? 236 LEU A O   1 
ATOM 1821 C CB  . LEU A 1 238 ? 14.054 -79.392  5.716   1.00 87.51  ? 236 LEU A CB  1 
ATOM 1822 C CG  . LEU A 1 238 ? 12.834 -80.056  6.356   1.00 94.36  ? 236 LEU A CG  1 
ATOM 1823 C CD1 . LEU A 1 238 ? 11.551 -79.382  5.872   1.00 102.73 ? 236 LEU A CD1 1 
ATOM 1824 C CD2 . LEU A 1 238 ? 12.815 -81.552  6.051   1.00 94.27  ? 236 LEU A CD2 1 
ATOM 1825 N N   . ASN A 1 239 ? 13.755 -77.333  8.412   1.00 86.77  ? 237 ASN A N   1 
ATOM 1826 C CA  . ASN A 1 239 ? 13.835 -77.271  9.868   1.00 81.98  ? 237 ASN A CA  1 
ATOM 1827 C C   . ASN A 1 239 ? 14.701 -76.098  10.317  1.00 91.06  ? 237 ASN A C   1 
ATOM 1828 O O   . ASN A 1 239 ? 15.004 -75.976  11.501  1.00 116.24 ? 237 ASN A O   1 
ATOM 1829 C CB  . ASN A 1 239 ? 14.275 -78.591  10.498  1.00 71.41  ? 237 ASN A CB  1 
ATOM 1830 C CG  . ASN A 1 239 ? 13.232 -79.680  10.338  1.00 80.09  ? 237 ASN A CG  1 
ATOM 1831 O OD1 . ASN A 1 239 ? 12.030 -79.414  10.142  1.00 68.64  ? 237 ASN A OD1 1 
ATOM 1832 N ND2 . ASN A 1 239 ? 13.679 -80.925  10.421  1.00 85.53  ? 237 ASN A ND2 1 
ATOM 1833 N N   . ALA A 1 240 ? 15.066 -75.216  9.381   1.00 93.49  ? 238 ALA A N   1 
ATOM 1834 C CA  . ALA A 1 240 ? 15.789 -73.998  9.714   1.00 98.52  ? 238 ALA A CA  1 
ATOM 1835 C C   . ALA A 1 240 ? 14.898 -72.806  9.386   1.00 97.87  ? 238 ALA A C   1 
ATOM 1836 O O   . ALA A 1 240 ? 14.259 -72.783  8.336   1.00 89.55  ? 238 ALA A O   1 
ATOM 1837 C CB  . ALA A 1 240 ? 17.102 -73.937  8.973   1.00 104.05 ? 238 ALA A CB  1 
ATOM 1838 N N   . ASP A 1 241 ? 14.856 -71.850  10.317  1.00 101.41 ? 239 ASP A N   1 
ATOM 1839 C CA  . ASP A 1 241 ? 13.872 -70.787  10.289  1.00 98.72  ? 239 ASP A CA  1 
ATOM 1840 C C   . ASP A 1 241 ? 14.387 -69.632  9.433   1.00 86.86  ? 239 ASP A C   1 
ATOM 1841 O O   . ASP A 1 241 ? 15.477 -69.127  9.683   1.00 80.28  ? 239 ASP A O   1 
ATOM 1842 C CB  . ASP A 1 241 ? 13.570 -70.330  11.705  1.00 99.48  ? 239 ASP A CB  1 
ATOM 1843 C CG  . ASP A 1 241 ? 12.631 -69.142  11.809  1.00 107.43 ? 239 ASP A CG  1 
ATOM 1844 O OD1 . ASP A 1 241 ? 12.047 -68.762  10.778  1.00 100.00 ? 239 ASP A OD1 1 
ATOM 1845 O OD2 . ASP A 1 241 ? 12.515 -68.595  12.918  1.00 138.61 ? 239 ASP A OD2 1 
ATOM 1846 N N   . PRO A 1 242 ? 13.623 -69.143  8.427   1.00 76.72  ? 240 PRO A N   1 
ATOM 1847 C CA  . PRO A 1 242 ? 14.091 -68.049  7.579   1.00 75.69  ? 240 PRO A CA  1 
ATOM 1848 C C   . PRO A 1 242 ? 14.640 -66.872  8.380   1.00 79.23  ? 240 PRO A C   1 
ATOM 1849 O O   . PRO A 1 242 ? 15.511 -66.153  7.909   1.00 90.40  ? 240 PRO A O   1 
ATOM 1850 C CB  . PRO A 1 242 ? 12.830 -67.651  6.777   1.00 75.65  ? 240 PRO A CB  1 
ATOM 1851 C CG  . PRO A 1 242 ? 11.995 -68.897  6.732   1.00 75.74  ? 240 PRO A CG  1 
ATOM 1852 C CD  . PRO A 1 242 ? 12.279 -69.609  8.044   1.00 77.76  ? 240 PRO A CD  1 
ATOM 1853 N N   . ARG A 1 243 ? 14.098 -66.669  9.582   1.00 78.33  ? 241 ARG A N   1 
ATOM 1854 C CA  . ARG A 1 243 ? 14.513 -65.584  10.451  1.00 81.15  ? 241 ARG A CA  1 
ATOM 1855 C C   . ARG A 1 243 ? 15.939 -65.837  10.936  1.00 78.72  ? 241 ARG A C   1 
ATOM 1856 O O   . ARG A 1 243 ? 16.717 -64.890  11.033  1.00 75.77  ? 241 ARG A O   1 
ATOM 1857 C CB  . ARG A 1 243 ? 13.512 -65.438  11.608  1.00 93.17  ? 241 ARG A CB  1 
ATOM 1858 C CG  . ARG A 1 243 ? 12.074 -65.196  11.160  1.00 96.04  ? 241 ARG A CG  1 
ATOM 1859 C CD  . ARG A 1 243 ? 11.038 -65.135  12.287  1.00 98.40  ? 241 ARG A CD  1 
ATOM 1860 N NE  . ARG A 1 243 ? 11.279 -64.068  13.265  1.00 101.54 ? 241 ARG A NE  1 
ATOM 1861 C CZ  . ARG A 1 243 ? 11.493 -64.254  14.568  1.00 109.66 ? 241 ARG A CZ  1 
ATOM 1862 N NH1 . ARG A 1 243 ? 11.352 -65.456  15.099  1.00 105.50 ? 241 ARG A NH1 1 
ATOM 1863 N NH2 . ARG A 1 243 ? 11.837 -63.236  15.346  1.00 108.62 ? 241 ARG A NH2 1 
ATOM 1864 N N   . TYR A 1 244 ? 16.258 -67.106  11.256  1.00 80.19  ? 242 TYR A N   1 
ATOM 1865 C CA  . TYR A 1 244 ? 17.606 -67.543  11.621  1.00 73.05  ? 242 TYR A CA  1 
ATOM 1866 C C   . TYR A 1 244 ? 18.545 -67.342  10.437  1.00 71.47  ? 242 TYR A C   1 
ATOM 1867 O O   . TYR A 1 244 ? 19.675 -66.883  10.600  1.00 75.03  ? 242 TYR A O   1 
ATOM 1868 C CB  . TYR A 1 244 ? 17.677 -69.014  12.063  1.00 71.52  ? 242 TYR A CB  1 
ATOM 1869 C CG  . TYR A 1 244 ? 19.032 -69.690  11.880  1.00 70.34  ? 242 TYR A CG  1 
ATOM 1870 C CD1 . TYR A 1 244 ? 20.015 -69.670  12.868  1.00 70.15  ? 242 TYR A CD1 1 
ATOM 1871 C CD2 . TYR A 1 244 ? 19.330 -70.357  10.703  1.00 76.31  ? 242 TYR A CD2 1 
ATOM 1872 C CE1 . TYR A 1 244 ? 21.247 -70.286  12.685  1.00 67.54  ? 242 TYR A CE1 1 
ATOM 1873 C CE2 . TYR A 1 244 ? 20.561 -70.969  10.505  1.00 78.84  ? 242 TYR A CE2 1 
ATOM 1874 C CZ  . TYR A 1 244 ? 21.529 -70.940  11.494  1.00 70.01  ? 242 TYR A CZ  1 
ATOM 1875 O OH  . TYR A 1 244 ? 22.722 -71.584  11.257  1.00 60.65  ? 242 TYR A OH  1 
ATOM 1876 N N   . ILE A 1 245 ? 18.058 -67.693  9.245   1.00 69.08  ? 243 ILE A N   1 
ATOM 1877 C CA  . ILE A 1 245 ? 18.847 -67.605  8.032   1.00 61.66  ? 243 ILE A CA  1 
ATOM 1878 C C   . ILE A 1 245 ? 19.172 -66.143  7.753   1.00 64.44  ? 243 ILE A C   1 
ATOM 1879 O O   . ILE A 1 245 ? 20.310 -65.833  7.444   1.00 65.55  ? 243 ILE A O   1 
ATOM 1880 C CB  . ILE A 1 245 ? 18.121 -68.283  6.859   1.00 66.70  ? 243 ILE A CB  1 
ATOM 1881 C CG1 . ILE A 1 245 ? 17.989 -69.807  7.104   1.00 66.32  ? 243 ILE A CG1 1 
ATOM 1882 C CG2 . ILE A 1 245 ? 18.839 -67.966  5.546   1.00 70.39  ? 243 ILE A CG2 1 
ATOM 1883 C CD1 . ILE A 1 245 ? 17.220 -70.594  6.054   1.00 61.42  ? 243 ILE A CD1 1 
ATOM 1884 N N   . GLU A 1 246 ? 18.178 -65.256  7.875   1.00 80.11  ? 244 GLU A N   1 
ATOM 1885 C CA  . GLU A 1 246 ? 18.367 -63.828  7.651   1.00 92.66  ? 244 GLU A CA  1 
ATOM 1886 C C   . GLU A 1 246 ? 19.351 -63.274  8.685   1.00 89.76  ? 244 GLU A C   1 
ATOM 1887 O O   . GLU A 1 246 ? 20.223 -62.478  8.338   1.00 84.42  ? 244 GLU A O   1 
ATOM 1888 C CB  . GLU A 1 246 ? 17.025 -63.087  7.699   1.00 100.44 ? 244 GLU A CB  1 
ATOM 1889 C CG  . GLU A 1 246 ? 17.025 -61.722  7.011   1.00 108.37 ? 244 GLU A CG  1 
ATOM 1890 C CD  . GLU A 1 246 ? 15.934 -60.765  7.478   1.00 122.33 ? 244 GLU A CD  1 
ATOM 1891 O OE1 . GLU A 1 246 ? 16.115 -60.177  8.569   1.00 135.47 ? 244 GLU A OE1 1 
ATOM 1892 O OE2 . GLU A 1 246 ? 14.904 -60.597  6.779   1.00 116.62 ? 244 GLU A OE2 1 
ATOM 1893 N N   . SER A 1 247 ? 19.215 -63.720  9.943   1.00 78.95  ? 245 SER A N   1 
ATOM 1894 C CA  . SER A 1 247 ? 20.015 -63.191  11.036  1.00 85.63  ? 245 SER A CA  1 
ATOM 1895 C C   . SER A 1 247 ? 21.458 -63.664  10.922  1.00 85.11  ? 245 SER A C   1 
ATOM 1896 O O   . SER A 1 247 ? 22.384 -62.851  10.953  1.00 93.08  ? 245 SER A O   1 
ATOM 1897 C CB  . SER A 1 247 ? 19.467 -63.569  12.383  1.00 90.23  ? 245 SER A CB  1 
ATOM 1898 O OG  . SER A 1 247 ? 20.350 -63.131  13.416  1.00 96.49  ? 245 SER A OG  1 
ATOM 1899 N N   . VAL A 1 248 ? 21.627 -64.985  10.808  1.00 76.36  ? 246 VAL A N   1 
ATOM 1900 C CA  . VAL A 1 248 ? 22.938 -65.602  10.895  1.00 74.52  ? 246 VAL A CA  1 
ATOM 1901 C C   . VAL A 1 248 ? 23.846 -65.022  9.809   1.00 77.72  ? 246 VAL A C   1 
ATOM 1902 O O   . VAL A 1 248 ? 25.047 -64.864  10.020  1.00 95.09  ? 246 VAL A O   1 
ATOM 1903 C CB  . VAL A 1 248 ? 22.855 -67.137  10.815  1.00 69.94  ? 246 VAL A CB  1 
ATOM 1904 C CG1 . VAL A 1 248 ? 22.484 -67.625  9.426   1.00 73.84  ? 246 VAL A CG1 1 
ATOM 1905 C CG2 . VAL A 1 248 ? 24.152 -67.793  11.243  1.00 70.75  ? 246 VAL A CG2 1 
ATOM 1906 N N   . VAL A 1 249 ? 23.272 -64.677  8.654   1.00 66.39  ? 247 VAL A N   1 
ATOM 1907 C CA  . VAL A 1 249 ? 24.038 -64.049  7.595   1.00 66.66  ? 247 VAL A CA  1 
ATOM 1908 C C   . VAL A 1 249 ? 24.485 -62.667  8.059   1.00 72.01  ? 247 VAL A C   1 
ATOM 1909 O O   . VAL A 1 249 ? 25.684 -62.387  8.110   1.00 59.80  ? 247 VAL A O   1 
ATOM 1910 C CB  . VAL A 1 249 ? 23.180 -64.016  6.319   1.00 67.22  ? 247 VAL A CB  1 
ATOM 1911 C CG1 . VAL A 1 249 ? 23.832 -63.217  5.191   1.00 68.10  ? 247 VAL A CG1 1 
ATOM 1912 C CG2 . VAL A 1 249 ? 22.833 -65.435  5.866   1.00 62.85  ? 247 VAL A CG2 1 
ATOM 1913 N N   . LYS A 1 250 ? 23.496 -61.837  8.421   1.00 81.95  ? 248 LYS A N   1 
ATOM 1914 C CA  . LYS A 1 250 ? 23.712 -60.482  8.911   1.00 88.10  ? 248 LYS A CA  1 
ATOM 1915 C C   . LYS A 1 250 ? 24.871 -60.458  9.913   1.00 82.78  ? 248 LYS A C   1 
ATOM 1916 O O   . LYS A 1 250 ? 25.750 -59.600  9.822   1.00 73.83  ? 248 LYS A O   1 
ATOM 1917 C CB  . LYS A 1 250 ? 22.345 -59.978  9.407   1.00 93.50  ? 248 LYS A CB  1 
ATOM 1918 C CG  . LYS A 1 250 ? 22.294 -59.016  10.595  1.00 115.75 ? 248 LYS A CG  1 
ATOM 1919 C CD  . LYS A 1 250 ? 21.064 -59.172  11.489  1.00 124.38 ? 248 LYS A CD  1 
ATOM 1920 C CE  . LYS A 1 250 ? 21.119 -58.296  12.706  1.00 123.10 ? 248 LYS A CE  1 
ATOM 1921 N NZ  . LYS A 1 250 ? 21.003 -56.877  12.361  1.00 120.86 ? 248 LYS A NZ  1 
ATOM 1922 N N   . HIS A 1 251 ? 24.880 -61.411  10.855  1.00 77.41  ? 249 HIS A N   1 
ATOM 1923 C CA  . HIS A 1 251 ? 25.934 -61.505  11.855  1.00 76.83  ? 249 HIS A CA  1 
ATOM 1924 C C   . HIS A 1 251 ? 27.275 -61.850  11.221  1.00 76.30  ? 249 HIS A C   1 
ATOM 1925 O O   . HIS A 1 251 ? 28.296 -61.242  11.549  1.00 71.13  ? 249 HIS A O   1 
ATOM 1926 C CB  . HIS A 1 251 ? 25.586 -62.544  12.925  1.00 78.60  ? 249 HIS A CB  1 
ATOM 1927 C CG  . HIS A 1 251 ? 24.692 -61.985  13.971  1.00 88.64  ? 249 HIS A CG  1 
ATOM 1928 N ND1 . HIS A 1 251 ? 24.956 -60.762  14.552  1.00 89.10  ? 249 HIS A ND1 1 
ATOM 1929 C CD2 . HIS A 1 251 ? 23.584 -62.459  14.549  1.00 92.37  ? 249 HIS A CD2 1 
ATOM 1930 C CE1 . HIS A 1 251 ? 24.019 -60.501  15.441  1.00 97.82  ? 249 HIS A CE1 1 
ATOM 1931 N NE2 . HIS A 1 251 ? 23.178 -61.521  15.452  1.00 101.96 ? 249 HIS A NE2 1 
ATOM 1932 N N   . LEU A 1 252 ? 27.263 -62.849  10.331  1.00 73.85  ? 250 LEU A N   1 
ATOM 1933 C CA  . LEU A 1 252 ? 28.482 -63.294  9.688   1.00 68.89  ? 250 LEU A CA  1 
ATOM 1934 C C   . LEU A 1 252 ? 29.112 -62.127  8.947   1.00 66.96  ? 250 LEU A C   1 
ATOM 1935 O O   . LEU A 1 252 ? 30.329 -62.036  8.909   1.00 64.97  ? 250 LEU A O   1 
ATOM 1936 C CB  . LEU A 1 252 ? 28.220 -64.468  8.751   1.00 69.44  ? 250 LEU A CB  1 
ATOM 1937 C CG  . LEU A 1 252 ? 28.179 -65.849  9.407   1.00 72.39  ? 250 LEU A CG  1 
ATOM 1938 C CD1 . LEU A 1 252 ? 27.694 -66.918  8.438   1.00 74.12  ? 250 LEU A CD1 1 
ATOM 1939 C CD2 . LEU A 1 252 ? 29.549 -66.219  9.952   1.00 72.67  ? 250 LEU A CD2 1 
ATOM 1940 N N   . ARG A 1 253 ? 28.276 -61.260  8.360   1.00 66.85  ? 251 ARG A N   1 
ATOM 1941 C CA  . ARG A 1 253 ? 28.747 -60.080  7.654   1.00 67.02  ? 251 ARG A CA  1 
ATOM 1942 C C   . ARG A 1 253 ? 29.489 -59.153  8.611   1.00 67.57  ? 251 ARG A C   1 
ATOM 1943 O O   . ARG A 1 253 ? 30.530 -58.613  8.258   1.00 68.66  ? 251 ARG A O   1 
ATOM 1944 C CB  . ARG A 1 253 ? 27.611 -59.249  7.051   1.00 71.34  ? 251 ARG A CB  1 
ATOM 1945 C CG  . ARG A 1 253 ? 26.792 -59.874  5.937   1.00 76.02  ? 251 ARG A CG  1 
ATOM 1946 C CD  . ARG A 1 253 ? 25.925 -58.814  5.283   1.00 77.60  ? 251 ARG A CD  1 
ATOM 1947 N NE  . ARG A 1 253 ? 26.650 -58.100  4.225   1.00 80.20  ? 251 ARG A NE  1 
ATOM 1948 C CZ  . ARG A 1 253 ? 26.086 -57.261  3.374   1.00 89.30  ? 251 ARG A CZ  1 
ATOM 1949 N NH1 . ARG A 1 253 ? 24.848 -56.855  3.593   1.00 102.51 ? 251 ARG A NH1 1 
ATOM 1950 N NH2 . ARG A 1 253 ? 26.753 -56.825  2.316   1.00 88.83  ? 251 ARG A NH2 1 
ATOM 1951 N N   . GLU A 1 254 ? 28.932 -58.943  9.809   1.00 68.67  ? 252 GLU A N   1 
ATOM 1952 C CA  . GLU A 1 254 ? 29.546 -58.055  10.780  1.00 73.31  ? 252 GLU A CA  1 
ATOM 1953 C C   . GLU A 1 254 ? 30.801 -58.706  11.348  1.00 70.05  ? 252 GLU A C   1 
ATOM 1954 O O   . GLU A 1 254 ? 31.869 -58.105  11.339  1.00 70.43  ? 252 GLU A O   1 
ATOM 1955 C CB  . GLU A 1 254 ? 28.571 -57.715  11.900  1.00 84.34  ? 252 GLU A CB  1 
ATOM 1956 C CG  . GLU A 1 254 ? 27.419 -56.837  11.420  1.00 95.60  ? 252 GLU A CG  1 
ATOM 1957 C CD  . GLU A 1 254 ? 26.274 -56.789  12.404  1.00 111.75 ? 252 GLU A CD  1 
ATOM 1958 O OE1 . GLU A 1 254 ? 26.499 -57.074  13.605  1.00 116.69 ? 252 GLU A OE1 1 
ATOM 1959 O OE2 . GLU A 1 254 ? 25.149 -56.540  11.922  1.00 115.04 ? 252 GLU A OE2 1 
ATOM 1960 N N   . ILE A 1 255 ? 30.654 -59.945  11.817  1.00 68.52  ? 253 ILE A N   1 
ATOM 1961 C CA  . ILE A 1 255 ? 31.760 -60.691  12.397  1.00 67.13  ? 253 ILE A CA  1 
ATOM 1962 C C   . ILE A 1 255 ? 32.950 -60.721  11.437  1.00 78.76  ? 253 ILE A C   1 
ATOM 1963 O O   . ILE A 1 255 ? 34.062 -60.362  11.814  1.00 79.39  ? 253 ILE A O   1 
ATOM 1964 C CB  . ILE A 1 255 ? 31.310 -62.114  12.752  1.00 59.47  ? 253 ILE A CB  1 
ATOM 1965 C CG1 . ILE A 1 255 ? 30.334 -62.103  13.914  1.00 60.63  ? 253 ILE A CG1 1 
ATOM 1966 C CG2 . ILE A 1 255 ? 32.517 -63.001  13.026  1.00 60.22  ? 253 ILE A CG2 1 
ATOM 1967 C CD1 . ILE A 1 255 ? 29.798 -63.470  14.303  1.00 64.24  ? 253 ILE A CD1 1 
ATOM 1968 N N   . SER A 1 256 ? 32.705 -61.191  10.207  1.00 87.93  ? 254 SER A N   1 
ATOM 1969 C CA  . SER A 1 256 ? 33.757 -61.465  9.236   1.00 80.93  ? 254 SER A CA  1 
ATOM 1970 C C   . SER A 1 256 ? 34.305 -60.162  8.665   1.00 70.38  ? 254 SER A C   1 
ATOM 1971 O O   . SER A 1 256 ? 35.505 -60.036  8.430   1.00 72.81  ? 254 SER A O   1 
ATOM 1972 C CB  . SER A 1 256 ? 33.262 -62.383  8.130   1.00 76.24  ? 254 SER A CB  1 
ATOM 1973 O OG  . SER A 1 256 ? 32.361 -61.717  7.254   1.00 73.47  ? 254 SER A OG  1 
ATOM 1974 N N   . GLY A 1 257 ? 33.416 -59.197  8.445   1.00 62.01  ? 255 GLY A N   1 
ATOM 1975 C CA  . GLY A 1 257 ? 33.797 -57.961  7.788   1.00 70.61  ? 255 GLY A CA  1 
ATOM 1976 C C   . GLY A 1 257 ? 33.395 -57.965  6.317   1.00 72.29  ? 255 GLY A C   1 
ATOM 1977 O O   . GLY A 1 257 ? 33.370 -56.908  5.685   1.00 68.75  ? 255 GLY A O   1 
ATOM 1978 N N   . TYR A 1 258 ? 32.968 -59.136  5.814   1.00 74.64  ? 256 TYR A N   1 
ATOM 1979 C CA  . TYR A 1 258 ? 32.803 -59.358  4.385   1.00 68.11  ? 256 TYR A CA  1 
ATOM 1980 C C   . TYR A 1 258 ? 31.362 -59.133  3.947   1.00 73.19  ? 256 TYR A C   1 
ATOM 1981 O O   . TYR A 1 258 ? 30.428 -59.418  4.696   1.00 67.35  ? 256 TYR A O   1 
ATOM 1982 C CB  . TYR A 1 258 ? 33.248 -60.764  3.987   1.00 59.81  ? 256 TYR A CB  1 
ATOM 1983 C CG  . TYR A 1 258 ? 34.763 -60.842  3.989   1.00 60.65  ? 256 TYR A CG  1 
ATOM 1984 C CD1 . TYR A 1 258 ? 35.522 -60.141  3.063   1.00 61.29  ? 256 TYR A CD1 1 
ATOM 1985 C CD2 . TYR A 1 258 ? 35.428 -61.598  4.935   1.00 63.74  ? 256 TYR A CD2 1 
ATOM 1986 C CE1 . TYR A 1 258 ? 36.901 -60.194  3.085   1.00 61.55  ? 256 TYR A CE1 1 
ATOM 1987 C CE2 . TYR A 1 258 ? 36.807 -61.653  4.974   1.00 62.12  ? 256 TYR A CE2 1 
ATOM 1988 C CZ  . TYR A 1 258 ? 37.544 -60.941  4.052   1.00 60.52  ? 256 TYR A CZ  1 
ATOM 1989 O OH  . TYR A 1 258 ? 38.900 -61.010  4.079   1.00 62.76  ? 256 TYR A OH  1 
ATOM 1990 N N   . PRO A 1 259 ? 31.162 -58.627  2.706   1.00 77.32  ? 257 PRO A N   1 
ATOM 1991 C CA  . PRO A 1 259 ? 29.817 -58.397  2.167   1.00 76.46  ? 257 PRO A CA  1 
ATOM 1992 C C   . PRO A 1 259 ? 29.108 -59.679  1.741   1.00 71.39  ? 257 PRO A C   1 
ATOM 1993 O O   . PRO A 1 259 ? 28.668 -59.803  0.598   1.00 70.65  ? 257 PRO A O   1 
ATOM 1994 C CB  . PRO A 1 259 ? 30.080 -57.447  0.994   1.00 82.94  ? 257 PRO A CB  1 
ATOM 1995 C CG  . PRO A 1 259 ? 31.486 -57.805  0.533   1.00 86.68  ? 257 PRO A CG  1 
ATOM 1996 C CD  . PRO A 1 259 ? 32.234 -58.219  1.781   1.00 79.39  ? 257 PRO A CD  1 
ATOM 1997 N N   . LEU A 1 260 ? 28.975 -60.604  2.703   1.00 70.91  ? 258 LEU A N   1 
ATOM 1998 C CA  . LEU A 1 260 ? 28.398 -61.914  2.461   1.00 64.73  ? 258 LEU A CA  1 
ATOM 1999 C C   . LEU A 1 260 ? 26.914 -61.750  2.177   1.00 70.57  ? 258 LEU A C   1 
ATOM 2000 O O   . LEU A 1 260 ? 26.298 -60.764  2.581   1.00 76.99  ? 258 LEU A O   1 
ATOM 2001 C CB  . LEU A 1 260 ? 28.607 -62.844  3.653   1.00 59.03  ? 258 LEU A CB  1 
ATOM 2002 C CG  . LEU A 1 260 ? 30.051 -63.023  4.128   1.00 57.16  ? 258 LEU A CG  1 
ATOM 2003 C CD1 . LEU A 1 260 ? 30.136 -64.029  5.258   1.00 59.64  ? 258 LEU A CD1 1 
ATOM 2004 C CD2 . LEU A 1 260 ? 30.960 -63.441  2.998   1.00 55.75  ? 258 LEU A CD2 1 
ATOM 2005 N N   . VAL A 1 261 ? 26.355 -62.735  1.479   1.00 73.29  ? 259 VAL A N   1 
ATOM 2006 C CA  . VAL A 1 261 ? 24.962 -62.687  1.094   1.00 77.58  ? 259 VAL A CA  1 
ATOM 2007 C C   . VAL A 1 261 ? 24.449 -64.117  1.044   1.00 77.26  ? 259 VAL A C   1 
ATOM 2008 O O   . VAL A 1 261 ? 25.196 -65.020  0.694   1.00 85.85  ? 259 VAL A O   1 
ATOM 2009 C CB  . VAL A 1 261 ? 24.803 -61.964  -0.254  1.00 76.94  ? 259 VAL A CB  1 
ATOM 2010 C CG1 . VAL A 1 261 ? 23.326 -61.776  -0.577  1.00 90.23  ? 259 VAL A CG1 1 
ATOM 2011 C CG2 . VAL A 1 261 ? 25.530 -60.620  -0.308  1.00 67.99  ? 259 VAL A CG2 1 
ATOM 2012 N N   . GLY A 1 262 ? 23.201 -64.331  1.465   1.00 83.77  ? 260 GLY A N   1 
ATOM 2013 C CA  . GLY A 1 262 ? 22.602 -65.651  1.369   1.00 81.22  ? 260 GLY A CA  1 
ATOM 2014 C C   . GLY A 1 262 ? 22.463 -66.008  -0.099  1.00 78.48  ? 260 GLY A C   1 
ATOM 2015 O O   . GLY A 1 262 ? 22.042 -65.169  -0.883  1.00 87.54  ? 260 GLY A O   1 
ATOM 2016 N N   . ALA A 1 263 ? 22.892 -67.212  -0.480  1.00 85.09  ? 261 ALA A N   1 
ATOM 2017 C CA  . ALA A 1 263 ? 22.838 -67.606  -1.877  1.00 90.62  ? 261 ALA A CA  1 
ATOM 2018 C C   . ALA A 1 263 ? 21.378 -67.831  -2.252  1.00 95.53  ? 261 ALA A C   1 
ATOM 2019 O O   . ALA A 1 263 ? 20.641 -68.406  -1.452  1.00 95.52  ? 261 ALA A O   1 
ATOM 2020 C CB  . ALA A 1 263 ? 23.677 -68.837  -2.096  1.00 92.43  ? 261 ALA A CB  1 
ATOM 2021 N N   . GLU A 1 264 ? 20.981 -67.354  -3.447  1.00 92.84  ? 262 GLU A N   1 
ATOM 2022 C CA  . GLU A 1 264 ? 19.592 -67.360  -3.892  1.00 87.58  ? 262 GLU A CA  1 
ATOM 2023 C C   . GLU A 1 264 ? 19.029 -68.783  -3.888  1.00 79.04  ? 262 GLU A C   1 
ATOM 2024 O O   . GLU A 1 264 ? 17.885 -69.009  -3.497  1.00 87.31  ? 262 GLU A O   1 
ATOM 2025 C CB  . GLU A 1 264 ? 19.447 -66.770  -5.297  1.00 94.01  ? 262 GLU A CB  1 
ATOM 2026 C CG  . GLU A 1 264 ? 19.332 -65.247  -5.364  1.00 103.47 ? 262 GLU A CG  1 
ATOM 2027 C CD  . GLU A 1 264 ? 19.115 -64.713  -6.782  1.00 113.31 ? 262 GLU A CD  1 
ATOM 2028 O OE1 . GLU A 1 264 ? 19.178 -65.520  -7.746  1.00 111.37 ? 262 GLU A OE1 1 
ATOM 2029 O OE2 . GLU A 1 264 ? 18.876 -63.488  -6.946  1.00 104.84 ? 262 GLU A OE2 1 
ATOM 2030 N N   . ASN A 1 265 ? 19.844 -69.740  -4.337  1.00 70.28  ? 263 ASN A N   1 
ATOM 2031 C CA  . ASN A 1 265 ? 19.468 -71.139  -4.346  1.00 68.86  ? 263 ASN A CA  1 
ATOM 2032 C C   . ASN A 1 265 ? 20.399 -71.878  -3.398  1.00 66.87  ? 263 ASN A C   1 
ATOM 2033 O O   . ASN A 1 265 ? 21.619 -71.834  -3.584  1.00 66.90  ? 263 ASN A O   1 
ATOM 2034 C CB  . ASN A 1 265 ? 19.557 -71.705  -5.758  1.00 67.01  ? 263 ASN A CB  1 
ATOM 2035 C CG  . ASN A 1 265 ? 19.070 -73.128  -5.861  1.00 62.82  ? 263 ASN A CG  1 
ATOM 2036 O OD1 . ASN A 1 265 ? 19.381 -73.983  -5.019  1.00 62.63  ? 263 ASN A OD1 1 
ATOM 2037 N ND2 . ASN A 1 265 ? 18.337 -73.402  -6.922  1.00 72.43  ? 263 ASN A ND2 1 
ATOM 2038 N N   . LEU A 1 266 ? 19.804 -72.579  -2.421  1.00 71.31  ? 264 LEU A N   1 
ATOM 2039 C CA  . LEU A 1 266 ? 20.575 -73.247  -1.384  1.00 80.27  ? 264 LEU A CA  1 
ATOM 2040 C C   . LEU A 1 266 ? 20.954 -74.653  -1.837  1.00 77.12  ? 264 LEU A C   1 
ATOM 2041 O O   . LEU A 1 266 ? 22.023 -75.132  -1.471  1.00 77.53  ? 264 LEU A O   1 
ATOM 2042 C CB  . LEU A 1 266 ? 19.880 -73.253  -0.019  1.00 80.04  ? 264 LEU A CB  1 
ATOM 2043 C CG  . LEU A 1 266 ? 20.059 -71.979  0.819   1.00 75.79  ? 264 LEU A CG  1 
ATOM 2044 C CD1 . LEU A 1 266 ? 19.240 -70.836  0.245   1.00 80.12  ? 264 LEU A CD1 1 
ATOM 2045 C CD2 . LEU A 1 266 ? 19.723 -72.166  2.277   1.00 70.12  ? 264 LEU A CD2 1 
ATOM 2046 N N   . VAL A 1 267 ? 20.097 -75.296  -2.642  1.00 81.11  ? 265 VAL A N   1 
ATOM 2047 C CA  . VAL A 1 267 ? 20.411 -76.606  -3.198  1.00 78.62  ? 265 VAL A CA  1 
ATOM 2048 C C   . VAL A 1 267 ? 21.666 -76.482  -4.059  1.00 73.49  ? 265 VAL A C   1 
ATOM 2049 O O   . VAL A 1 267 ? 22.582 -77.311  -3.961  1.00 71.52  ? 265 VAL A O   1 
ATOM 2050 C CB  . VAL A 1 267 ? 19.224 -77.201  -3.986  1.00 76.20  ? 265 VAL A CB  1 
ATOM 2051 C CG1 . VAL A 1 267 ? 19.654 -78.319  -4.931  1.00 82.93  ? 265 VAL A CG1 1 
ATOM 2052 C CG2 . VAL A 1 267 ? 18.125 -77.697  -3.049  1.00 77.10  ? 265 VAL A CG2 1 
ATOM 2053 N N   . ASP A 1 268 ? 21.682 -75.417  -4.871  1.00 65.33  ? 266 ASP A N   1 
ATOM 2054 C CA  . ASP A 1 268 ? 22.778 -75.115  -5.771  1.00 62.22  ? 266 ASP A CA  1 
ATOM 2055 C C   . ASP A 1 268 ? 24.067 -74.890  -4.989  1.00 62.23  ? 266 ASP A C   1 
ATOM 2056 O O   . ASP A 1 268 ? 25.068 -75.549  -5.263  1.00 64.52  ? 266 ASP A O   1 
ATOM 2057 C CB  . ASP A 1 268 ? 22.427 -73.933  -6.651  1.00 59.93  ? 266 ASP A CB  1 
ATOM 2058 C CG  . ASP A 1 268 ? 23.608 -73.169  -7.222  1.00 61.38  ? 266 ASP A CG  1 
ATOM 2059 O OD1 . ASP A 1 268 ? 24.554 -73.814  -7.740  1.00 49.92  ? 266 ASP A OD1 1 
ATOM 2060 O OD2 . ASP A 1 268 ? 23.551 -71.929  -7.140  1.00 69.50  ? 266 ASP A OD2 1 
ATOM 2061 N N   . ALA A 1 269 ? 24.037 -73.973  -4.015  1.00 62.34  ? 267 ALA A N   1 
ATOM 2062 C CA  . ALA A 1 269 ? 25.251 -73.584  -3.306  1.00 63.44  ? 267 ALA A CA  1 
ATOM 2063 C C   . ALA A 1 269 ? 25.752 -74.701  -2.396  1.00 60.26  ? 267 ALA A C   1 
ATOM 2064 O O   . ALA A 1 269 ? 26.834 -74.572  -1.828  1.00 57.46  ? 267 ALA A O   1 
ATOM 2065 C CB  . ALA A 1 269 ? 25.025 -72.328  -2.499  1.00 63.29  ? 267 ALA A CB  1 
ATOM 2066 N N   . THR A 1 270 ? 24.966 -75.776  -2.249  1.00 58.56  ? 268 THR A N   1 
ATOM 2067 C CA  . THR A 1 270 ? 25.317 -76.863  -1.349  1.00 57.54  ? 268 THR A CA  1 
ATOM 2068 C C   . THR A 1 270 ? 25.974 -78.010  -2.102  1.00 58.84  ? 268 THR A C   1 
ATOM 2069 O O   . THR A 1 270 ? 26.727 -78.775  -1.492  1.00 54.66  ? 268 THR A O   1 
ATOM 2070 C CB  . THR A 1 270 ? 24.069 -77.348  -0.623  1.00 60.68  ? 268 THR A CB  1 
ATOM 2071 O OG1 . THR A 1 270 ? 23.758 -76.225  0.190   1.00 58.52  ? 268 THR A OG1 1 
ATOM 2072 C CG2 . THR A 1 270 ? 24.325 -78.562  0.253   1.00 63.83  ? 268 THR A CG2 1 
ATOM 2073 N N   . GLN A 1 271 ? 25.665 -78.151  -3.402  1.00 60.33  ? 269 GLN A N   1 
ATOM 2074 C CA  . GLN A 1 271 ? 26.152 -79.305  -4.141  1.00 62.27  ? 269 GLN A CA  1 
ATOM 2075 C C   . GLN A 1 271 ? 27.241 -78.934  -5.156  1.00 60.30  ? 269 GLN A C   1 
ATOM 2076 O O   . GLN A 1 271 ? 27.985 -79.815  -5.588  1.00 66.17  ? 269 GLN A O   1 
ATOM 2077 C CB  . GLN A 1 271 ? 24.959 -80.120  -4.648  1.00 62.07  ? 269 GLN A CB  1 
ATOM 2078 C CG  . GLN A 1 271 ? 24.262 -79.635  -5.914  1.00 57.82  ? 269 GLN A CG  1 
ATOM 2079 C CD  . GLN A 1 271 ? 23.182 -80.613  -6.333  1.00 61.20  ? 269 GLN A CD  1 
ATOM 2080 O OE1 . GLN A 1 271 ? 23.200 -81.196  -7.428  1.00 61.87  ? 269 GLN A OE1 1 
ATOM 2081 N NE2 . GLN A 1 271 ? 22.245 -80.840  -5.423  1.00 67.96  ? 269 GLN A NE2 1 
ATOM 2082 N N   . ASN A 1 272 ? 27.395 -77.647  -5.492  1.00 54.48  ? 270 ASN A N   1 
ATOM 2083 C CA  . ASN A 1 272 ? 28.337 -77.262  -6.534  1.00 55.90  ? 270 ASN A CA  1 
ATOM 2084 C C   . ASN A 1 272 ? 29.598 -76.699  -5.889  1.00 54.80  ? 270 ASN A C   1 
ATOM 2085 O O   . ASN A 1 272 ? 29.520 -75.906  -4.967  1.00 59.51  ? 270 ASN A O   1 
ATOM 2086 C CB  . ASN A 1 272 ? 27.721 -76.318  -7.571  1.00 56.47  ? 270 ASN A CB  1 
ATOM 2087 C CG  . ASN A 1 272 ? 26.560 -76.929  -8.324  1.00 61.93  ? 270 ASN A CG  1 
ATOM 2088 O OD1 . ASN A 1 272 ? 26.560 -78.136  -8.611  1.00 69.81  ? 270 ASN A OD1 1 
ATOM 2089 N ND2 . ASN A 1 272 ? 25.545 -76.127  -8.627  1.00 57.42  ? 270 ASN A ND2 1 
ATOM 2090 N N   . THR A 1 273 ? 30.764 -77.105  -6.398  1.00 64.01  ? 271 THR A N   1 
ATOM 2091 C CA  . THR A 1 273 ? 32.037 -76.706  -5.815  1.00 61.47  ? 271 THR A CA  1 
ATOM 2092 C C   . THR A 1 273 ? 32.803 -75.815  -6.791  1.00 56.95  ? 271 THR A C   1 
ATOM 2093 O O   . THR A 1 273 ? 34.029 -75.768  -6.759  1.00 57.83  ? 271 THR A O   1 
ATOM 2094 C CB  . THR A 1 273 ? 32.824 -77.958  -5.422  1.00 59.23  ? 271 THR A CB  1 
ATOM 2095 O OG1 . THR A 1 273 ? 33.188 -78.712  -6.570  1.00 50.74  ? 271 THR A OG1 1 
ATOM 2096 C CG2 . THR A 1 273 ? 31.987 -78.902  -4.585  1.00 63.85  ? 271 THR A CG2 1 
ATOM 2097 N N   . ASP A 1 274 ? 32.073 -75.080  -7.630  1.00 52.97  ? 272 ASP A N   1 
ATOM 2098 C CA  . ASP A 1 274 ? 32.694 -74.409  -8.758  1.00 55.82  ? 272 ASP A CA  1 
ATOM 2099 C C   . ASP A 1 274 ? 33.320 -73.088  -8.317  1.00 54.93  ? 272 ASP A C   1 
ATOM 2100 O O   . ASP A 1 274 ? 34.136 -72.512  -9.034  1.00 46.32  ? 272 ASP A O   1 
ATOM 2101 C CB  . ASP A 1 274 ? 31.709 -74.219  -9.897  1.00 57.22  ? 272 ASP A CB  1 
ATOM 2102 C CG  . ASP A 1 274 ? 30.497 -73.382  -9.548  1.00 58.08  ? 272 ASP A CG  1 
ATOM 2103 O OD1 . ASP A 1 274 ? 29.790 -73.760  -8.597  1.00 64.37  ? 272 ASP A OD1 1 
ATOM 2104 O OD2 . ASP A 1 274 ? 30.286 -72.366  -10.229 1.00 62.52  ? 272 ASP A OD2 1 
ATOM 2105 N N   . ALA A 1 275 ? 32.928 -72.611  -7.134  1.00 61.09  ? 273 ALA A N   1 
ATOM 2106 C CA  . ALA A 1 275 ? 33.495 -71.385  -6.597  1.00 65.45  ? 273 ALA A CA  1 
ATOM 2107 C C   . ALA A 1 275 ? 34.969 -71.597  -6.311  1.00 57.59  ? 273 ALA A C   1 
ATOM 2108 O O   . ALA A 1 275 ? 35.768 -70.690  -6.534  1.00 57.97  ? 273 ALA A O   1 
ATOM 2109 C CB  . ALA A 1 275 ? 32.761 -70.974  -5.346  1.00 77.21  ? 273 ALA A CB  1 
ATOM 2110 N N   . TYR A 1 276 ? 35.277 -72.812  -5.833  1.00 55.77  ? 274 TYR A N   1 
ATOM 2111 C CA  . TYR A 1 276 ? 36.622 -73.206  -5.441  1.00 61.26  ? 274 TYR A CA  1 
ATOM 2112 C C   . TYR A 1 276 ? 37.470 -73.526  -6.673  1.00 60.88  ? 274 TYR A C   1 
ATOM 2113 O O   . TYR A 1 276 ? 38.628 -73.119  -6.743  1.00 67.13  ? 274 TYR A O   1 
ATOM 2114 C CB  . TYR A 1 276 ? 36.640 -74.439  -4.532  1.00 65.67  ? 274 TYR A CB  1 
ATOM 2115 C CG  . TYR A 1 276 ? 35.765 -74.427  -3.282  1.00 64.06  ? 274 TYR A CG  1 
ATOM 2116 C CD1 . TYR A 1 276 ? 35.588 -73.283  -2.519  1.00 63.51  ? 274 TYR A CD1 1 
ATOM 2117 C CD2 . TYR A 1 276 ? 35.129 -75.589  -2.860  1.00 63.54  ? 274 TYR A CD2 1 
ATOM 2118 C CE1 . TYR A 1 276 ? 34.791 -73.292  -1.388  1.00 68.67  ? 274 TYR A CE1 1 
ATOM 2119 C CE2 . TYR A 1 276 ? 34.323 -75.609  -1.739  1.00 68.90  ? 274 TYR A CE2 1 
ATOM 2120 C CZ  . TYR A 1 276 ? 34.157 -74.457  -0.996  1.00 72.78  ? 274 TYR A CZ  1 
ATOM 2121 O OH  . TYR A 1 276 ? 33.368 -74.499  0.118   1.00 75.10  ? 274 TYR A OH  1 
ATOM 2122 N N   . THR A 1 277 ? 36.920 -74.284  -7.631  1.00 55.87  ? 275 THR A N   1 
ATOM 2123 C CA  . THR A 1 277 ? 37.678 -74.630  -8.824  1.00 58.44  ? 275 THR A CA  1 
ATOM 2124 C C   . THR A 1 277 ? 38.038 -73.355  -9.593  1.00 59.70  ? 275 THR A C   1 
ATOM 2125 O O   . THR A 1 277 ? 39.075 -73.316  -10.279 1.00 59.28  ? 275 THR A O   1 
ATOM 2126 C CB  . THR A 1 277 ? 36.930 -75.639  -9.701  1.00 57.57  ? 275 THR A CB  1 
ATOM 2127 O OG1 . THR A 1 277 ? 35.569 -75.252  -9.867  1.00 52.53  ? 275 THR A OG1 1 
ATOM 2128 C CG2 . THR A 1 277 ? 36.979 -77.038  -9.116  1.00 55.58  ? 275 THR A CG2 1 
ATOM 2129 N N   . GLU A 1 278 ? 37.175 -72.332  -9.441  1.00 54.47  ? 276 GLU A N   1 
ATOM 2130 C CA  . GLU A 1 278 ? 37.318 -71.052  -10.117 1.00 55.97  ? 276 GLU A CA  1 
ATOM 2131 C C   . GLU A 1 278 ? 38.521 -70.292  -9.561  1.00 54.03  ? 276 GLU A C   1 
ATOM 2132 O O   . GLU A 1 278 ? 39.341 -69.768  -10.318 1.00 51.62  ? 276 GLU A O   1 
ATOM 2133 C CB  . GLU A 1 278 ? 36.033 -70.235  -9.982  1.00 57.65  ? 276 GLU A CB  1 
ATOM 2134 C CG  . GLU A 1 278 ? 36.100 -68.847  -10.616 1.00 60.02  ? 276 GLU A CG  1 
ATOM 2135 C CD  . GLU A 1 278 ? 34.878 -67.990  -10.317 1.00 71.14  ? 276 GLU A CD  1 
ATOM 2136 O OE1 . GLU A 1 278 ? 34.923 -66.778  -10.598 1.00 70.66  ? 276 GLU A OE1 1 
ATOM 2137 O OE2 . GLU A 1 278 ? 33.878 -68.511  -9.779  1.00 88.10  ? 276 GLU A OE2 1 
ATOM 2138 N N   . VAL A 1 279 ? 38.603 -70.231  -8.231  1.00 53.22  ? 277 VAL A N   1 
ATOM 2139 C CA  . VAL A 1 279 ? 39.720 -69.585  -7.563  1.00 53.00  ? 277 VAL A CA  1 
ATOM 2140 C C   . VAL A 1 279 ? 41.013 -70.315  -7.917  1.00 52.38  ? 277 VAL A C   1 
ATOM 2141 O O   . VAL A 1 279 ? 41.972 -69.670  -8.325  1.00 61.79  ? 277 VAL A O   1 
ATOM 2142 C CB  . VAL A 1 279 ? 39.496 -69.536  -6.041  1.00 57.73  ? 277 VAL A CB  1 
ATOM 2143 C CG1 . VAL A 1 279 ? 40.753 -69.124  -5.293  1.00 57.95  ? 277 VAL A CG1 1 
ATOM 2144 C CG2 . VAL A 1 279 ? 38.325 -68.635  -5.659  1.00 62.62  ? 277 VAL A CG2 1 
ATOM 2145 N N   . SER A 1 280 ? 41.046 -71.646  -7.764  1.00 51.26  ? 278 SER A N   1 
ATOM 2146 C CA  . SER A 1 280 ? 42.252 -72.394  -8.076  1.00 57.94  ? 278 SER A CA  1 
ATOM 2147 C C   . SER A 1 280 ? 42.703 -72.070  -9.494  1.00 59.35  ? 278 SER A C   1 
ATOM 2148 O O   . SER A 1 280 ? 43.872 -71.762  -9.739  1.00 57.46  ? 278 SER A O   1 
ATOM 2149 C CB  . SER A 1 280 ? 42.095 -73.877  -7.917  1.00 61.07  ? 278 SER A CB  1 
ATOM 2150 O OG  . SER A 1 280 ? 43.375 -74.499  -8.041  1.00 63.71  ? 278 SER A OG  1 
ATOM 2151 N N   . ALA A 1 281 ? 41.751 -72.128  -10.421 1.00 58.41  ? 279 ALA A N   1 
ATOM 2152 C CA  . ALA A 1 281 ? 42.045 -71.819  -11.807 1.00 61.74  ? 279 ALA A CA  1 
ATOM 2153 C C   . ALA A 1 281 ? 42.811 -70.498  -11.952 1.00 55.10  ? 279 ALA A C   1 
ATOM 2154 O O   . ALA A 1 281 ? 43.826 -70.449  -12.652 1.00 48.50  ? 279 ALA A O   1 
ATOM 2155 C CB  . ALA A 1 281 ? 40.754 -71.798  -12.567 1.00 68.38  ? 279 ALA A CB  1 
ATOM 2156 N N   . ALA A 1 282 ? 42.323 -69.438  -11.288 1.00 55.11  ? 280 ALA A N   1 
ATOM 2157 C CA  . ALA A 1 282 ? 42.915 -68.103  -11.361 1.00 55.37  ? 280 ALA A CA  1 
ATOM 2158 C C   . ALA A 1 282 ? 44.343 -68.092  -10.822 1.00 55.88  ? 280 ALA A C   1 
ATOM 2159 O O   . ALA A 1 282 ? 45.199 -67.344  -11.303 1.00 66.03  ? 280 ALA A O   1 
ATOM 2160 C CB  . ALA A 1 282 ? 42.081 -67.097  -10.589 1.00 52.16  ? 280 ALA A CB  1 
ATOM 2161 N N   . LEU A 1 283 ? 44.570 -68.900  -9.787  1.00 53.09  ? 281 LEU A N   1 
ATOM 2162 C CA  . LEU A 1 283 ? 45.857 -68.964  -9.126  1.00 56.40  ? 281 LEU A CA  1 
ATOM 2163 C C   . LEU A 1 283 ? 46.855 -69.693  -10.022 1.00 59.01  ? 281 LEU A C   1 
ATOM 2164 O O   . LEU A 1 283 ? 48.036 -69.338  -10.058 1.00 55.39  ? 281 LEU A O   1 
ATOM 2165 C CB  . LEU A 1 283 ? 45.688 -69.698  -7.794  1.00 54.79  ? 281 LEU A CB  1 
ATOM 2166 C CG  . LEU A 1 283 ? 44.727 -69.091  -6.768  1.00 48.94  ? 281 LEU A CG  1 
ATOM 2167 C CD1 . LEU A 1 283 ? 44.589 -70.084  -5.662  1.00 47.87  ? 281 LEU A CD1 1 
ATOM 2168 C CD2 . LEU A 1 283 ? 45.165 -67.753  -6.195  1.00 52.42  ? 281 LEU A CD2 1 
ATOM 2169 N N   . LYS A 1 284 ? 46.375 -70.752  -10.690 1.00 61.55  ? 282 LYS A N   1 
ATOM 2170 C CA  . LYS A 1 284 ? 47.241 -71.560  -11.530 1.00 60.86  ? 282 LYS A CA  1 
ATOM 2171 C C   . LYS A 1 284 ? 47.793 -70.652  -12.618 1.00 55.39  ? 282 LYS A C   1 
ATOM 2172 O O   . LYS A 1 284 ? 48.999 -70.530  -12.793 1.00 57.67  ? 282 LYS A O   1 
ATOM 2173 C CB  . LYS A 1 284 ? 46.515 -72.753  -12.150 1.00 63.06  ? 282 LYS A CB  1 
ATOM 2174 C CG  . LYS A 1 284 ? 47.441 -73.782  -12.779 1.00 67.83  ? 282 LYS A CG  1 
ATOM 2175 C CD  . LYS A 1 284 ? 46.879 -74.326  -14.090 1.00 85.97  ? 282 LYS A CD  1 
ATOM 2176 C CE  . LYS A 1 284 ? 45.435 -74.773  -14.069 1.00 92.75  ? 282 LYS A CE  1 
ATOM 2177 N NZ  . LYS A 1 284 ? 44.710 -74.410  -15.299 1.00 101.13 ? 282 LYS A NZ  1 
ATOM 2178 N N   . VAL A 1 285 ? 46.891 -69.948  -13.290 1.00 50.91  ? 283 VAL A N   1 
ATOM 2179 C CA  . VAL A 1 285 ? 47.297 -68.978  -14.287 1.00 57.64  ? 283 VAL A CA  1 
ATOM 2180 C C   . VAL A 1 285 ? 48.371 -68.053  -13.724 1.00 60.72  ? 283 VAL A C   1 
ATOM 2181 O O   . VAL A 1 285 ? 49.399 -67.837  -14.361 1.00 60.77  ? 283 VAL A O   1 
ATOM 2182 C CB  . VAL A 1 285 ? 46.082 -68.170  -14.761 1.00 63.21  ? 283 VAL A CB  1 
ATOM 2183 C CG1 . VAL A 1 285 ? 46.490 -66.996  -15.654 1.00 63.14  ? 283 VAL A CG1 1 
ATOM 2184 C CG2 . VAL A 1 285 ? 45.083 -69.087  -15.453 1.00 64.21  ? 283 VAL A CG2 1 
ATOM 2185 N N   . CYS A 1 286 ? 48.099 -67.484  -12.544 1.00 67.07  ? 284 CYS A N   1 
ATOM 2186 C CA  . CYS A 1 286 ? 49.025 -66.564  -11.902 1.00 67.14  ? 284 CYS A CA  1 
ATOM 2187 C C   . CYS A 1 286 ? 50.429 -67.163  -11.881 1.00 61.70  ? 284 CYS A C   1 
ATOM 2188 O O   . CYS A 1 286 ? 51.376 -66.571  -12.388 1.00 53.28  ? 284 CYS A O   1 
ATOM 2189 C CB  . CYS A 1 286 ? 48.561 -66.202  -10.495 1.00 67.52  ? 284 CYS A CB  1 
ATOM 2190 S SG  . CYS A 1 286 ? 49.630 -64.966  -9.719  1.00 71.05  ? 284 CYS A SG  1 
ATOM 2191 N N   . MET A 1 287 ? 50.539 -68.371  -11.330 1.00 65.41  ? 285 MET A N   1 
ATOM 2192 C CA  . MET A 1 287 ? 51.833 -68.993  -11.110 1.00 63.60  ? 285 MET A CA  1 
ATOM 2193 C C   . MET A 1 287 ? 52.480 -69.410  -12.427 1.00 60.40  ? 285 MET A C   1 
ATOM 2194 O O   . MET A 1 287 ? 53.700 -69.464  -12.477 1.00 73.20  ? 285 MET A O   1 
ATOM 2195 C CB  . MET A 1 287 ? 51.724 -70.201  -10.173 1.00 62.67  ? 285 MET A CB  1 
ATOM 2196 C CG  . MET A 1 287 ? 51.310 -69.833  -8.752  1.00 66.44  ? 285 MET A CG  1 
ATOM 2197 S SD  . MET A 1 287 ? 52.348 -68.582  -7.965  1.00 62.28  ? 285 MET A SD  1 
ATOM 2198 C CE  . MET A 1 287 ? 54.007 -69.217  -8.252  1.00 58.42  ? 285 MET A CE  1 
ATOM 2199 N N   . MET A 1 288 ? 51.706 -69.711  -13.480 1.00 55.42  ? 286 MET A N   1 
ATOM 2200 C CA  . MET A 1 288 ? 52.326 -69.980  -14.769 1.00 56.68  ? 286 MET A CA  1 
ATOM 2201 C C   . MET A 1 288 ? 53.130 -68.747  -15.158 1.00 53.24  ? 286 MET A C   1 
ATOM 2202 O O   . MET A 1 288 ? 54.287 -68.856  -15.543 1.00 51.82  ? 286 MET A O   1 
ATOM 2203 C CB  . MET A 1 288 ? 51.348 -70.242  -15.923 1.00 68.43  ? 286 MET A CB  1 
ATOM 2204 C CG  . MET A 1 288 ? 50.313 -71.336  -15.723 1.00 74.80  ? 286 MET A CG  1 
ATOM 2205 S SD  . MET A 1 288 ? 50.911 -72.708  -14.724 1.00 87.80  ? 286 MET A SD  1 
ATOM 2206 C CE  . MET A 1 288 ? 52.342 -73.285  -15.636 1.00 74.50  ? 286 MET A CE  1 
ATOM 2207 N N   . ASN A 1 289 ? 52.507 -67.574  -15.014 1.00 52.26  ? 287 ASN A N   1 
ATOM 2208 C CA  . ASN A 1 289 ? 53.124 -66.315  -15.397 1.00 54.34  ? 287 ASN A CA  1 
ATOM 2209 C C   . ASN A 1 289 ? 54.377 -66.079  -14.559 1.00 54.96  ? 287 ASN A C   1 
ATOM 2210 O O   . ASN A 1 289 ? 55.416 -65.706  -15.093 1.00 49.73  ? 287 ASN A O   1 
ATOM 2211 C CB  . ASN A 1 289 ? 52.155 -65.146  -15.260 1.00 54.30  ? 287 ASN A CB  1 
ATOM 2212 C CG  . ASN A 1 289 ? 50.907 -65.346  -16.090 1.00 56.04  ? 287 ASN A CG  1 
ATOM 2213 O OD1 . ASN A 1 289 ? 50.917 -66.115  -17.057 1.00 65.02  ? 287 ASN A OD1 1 
ATOM 2214 N ND2 . ASN A 1 289 ? 49.820 -64.673  -15.746 1.00 52.94  ? 287 ASN A ND2 1 
ATOM 2215 N N   . MET A 1 290 ? 54.269 -66.306  -13.247 1.00 55.48  ? 288 MET A N   1 
ATOM 2216 C CA  . MET A 1 290 ? 55.346 -65.978  -12.330 1.00 56.67  ? 288 MET A CA  1 
ATOM 2217 C C   . MET A 1 290 ? 56.500 -66.955  -12.513 1.00 51.73  ? 288 MET A C   1 
ATOM 2218 O O   . MET A 1 290 ? 57.663 -66.558  -12.516 1.00 49.20  ? 288 MET A O   1 
ATOM 2219 C CB  . MET A 1 290 ? 54.862 -66.031  -10.877 1.00 63.10  ? 288 MET A CB  1 
ATOM 2220 C CG  . MET A 1 290 ? 53.729 -65.064  -10.556 1.00 73.23  ? 288 MET A CG  1 
ATOM 2221 S SD  . MET A 1 290 ? 53.961 -63.363  -11.113 1.00 76.43  ? 288 MET A SD  1 
ATOM 2222 C CE  . MET A 1 290 ? 55.671 -63.154  -10.587 1.00 64.89  ? 288 MET A CE  1 
ATOM 2223 N N   . SER A 1 291 ? 56.156 -68.235  -12.648 1.00 49.14  ? 289 SER A N   1 
ATOM 2224 C CA  . SER A 1 291 ? 57.136 -69.271  -12.903 1.00 47.30  ? 289 SER A CA  1 
ATOM 2225 C C   . SER A 1 291 ? 57.951 -68.891  -14.125 1.00 51.13  ? 289 SER A C   1 
ATOM 2226 O O   . SER A 1 291 ? 59.164 -69.053  -14.109 1.00 53.58  ? 289 SER A O   1 
ATOM 2227 C CB  . SER A 1 291 ? 56.506 -70.606  -13.106 1.00 46.34  ? 289 SER A CB  1 
ATOM 2228 O OG  . SER A 1 291 ? 57.502 -71.613  -13.158 1.00 40.87  ? 289 SER A OG  1 
ATOM 2229 N N   . LYS A 1 292 ? 57.283 -68.368  -15.160 1.00 52.89  ? 290 LYS A N   1 
ATOM 2230 C CA  . LYS A 1 292 ? 57.981 -67.859  -16.336 1.00 58.51  ? 290 LYS A CA  1 
ATOM 2231 C C   . LYS A 1 292 ? 58.915 -66.708  -15.951 1.00 55.84  ? 290 LYS A C   1 
ATOM 2232 O O   . LYS A 1 292 ? 60.128 -66.780  -16.154 1.00 54.06  ? 290 LYS A O   1 
ATOM 2233 C CB  . LYS A 1 292 ? 56.989 -67.412  -17.419 1.00 61.44  ? 290 LYS A CB  1 
ATOM 2234 C CG  . LYS A 1 292 ? 57.569 -67.105  -18.797 1.00 60.32  ? 290 LYS A CG  1 
ATOM 2235 C CD  . LYS A 1 292 ? 58.026 -65.669  -19.017 1.00 56.66  ? 290 LYS A CD  1 
ATOM 2236 C CE  . LYS A 1 292 ? 58.465 -65.411  -20.428 1.00 57.33  ? 290 LYS A CE  1 
ATOM 2237 N NZ  . LYS A 1 292 ? 58.660 -63.976  -20.641 1.00 60.65  ? 290 LYS A NZ  1 
ATOM 2238 N N   . ILE A 1 293 ? 58.353 -65.648  -15.363 1.00 54.99  ? 291 ILE A N   1 
ATOM 2239 C CA  . ILE A 1 293 ? 59.149 -64.486  -15.014 1.00 52.90  ? 291 ILE A CA  1 
ATOM 2240 C C   . ILE A 1 293 ? 60.355 -64.945  -14.205 1.00 50.82  ? 291 ILE A C   1 
ATOM 2241 O O   . ILE A 1 293 ? 61.458 -64.469  -14.428 1.00 48.97  ? 291 ILE A O   1 
ATOM 2242 C CB  . ILE A 1 293 ? 58.312 -63.441  -14.262 1.00 52.04  ? 291 ILE A CB  1 
ATOM 2243 C CG1 . ILE A 1 293 ? 57.152 -62.955  -15.093 1.00 53.52  ? 291 ILE A CG1 1 
ATOM 2244 C CG2 . ILE A 1 293 ? 59.191 -62.271  -13.833 1.00 55.09  ? 291 ILE A CG2 1 
ATOM 2245 C CD1 . ILE A 1 293 ? 56.072 -62.270  -14.288 1.00 57.47  ? 291 ILE A CD1 1 
ATOM 2246 N N   . ALA A 1 294 ? 60.136 -65.885  -13.283 1.00 52.31  ? 292 ALA A N   1 
ATOM 2247 C CA  . ALA A 1 294 ? 61.226 -66.472  -12.522 1.00 58.43  ? 292 ALA A CA  1 
ATOM 2248 C C   . ALA A 1 294 ? 62.278 -67.060  -13.457 1.00 56.44  ? 292 ALA A C   1 
ATOM 2249 O O   . ALA A 1 294 ? 63.463 -66.782  -13.299 1.00 62.46  ? 292 ALA A O   1 
ATOM 2250 C CB  . ALA A 1 294 ? 60.703 -67.516  -11.558 1.00 59.17  ? 292 ALA A CB  1 
ATOM 2251 N N   . ASN A 1 295 ? 61.848 -67.876  -14.421 1.00 55.78  ? 293 ASN A N   1 
ATOM 2252 C CA  . ASN A 1 295 ? 62.793 -68.548  -15.302 1.00 63.14  ? 293 ASN A CA  1 
ATOM 2253 C C   . ASN A 1 295 ? 63.588 -67.519  -16.101 1.00 63.56  ? 293 ASN A C   1 
ATOM 2254 O O   . ASN A 1 295 ? 64.766 -67.739  -16.366 1.00 69.39  ? 293 ASN A O   1 
ATOM 2255 C CB  . ASN A 1 295 ? 62.125 -69.542  -16.244 1.00 62.62  ? 293 ASN A CB  1 
ATOM 2256 C CG  . ASN A 1 295 ? 61.419 -70.649  -15.497 1.00 59.07  ? 293 ASN A CG  1 
ATOM 2257 O OD1 . ASN A 1 295 ? 61.993 -71.270  -14.593 1.00 57.01  ? 293 ASN A OD1 1 
ATOM 2258 N ND2 . ASN A 1 295 ? 60.168 -70.904  -15.850 1.00 60.94  ? 293 ASN A ND2 1 
ATOM 2259 N N   . ASP A 1 296 ? 62.939 -66.407  -16.470 1.00 58.06  ? 294 ASP A N   1 
ATOM 2260 C CA  . ASP A 1 296 ? 63.607 -65.308  -17.146 1.00 57.83  ? 294 ASP A CA  1 
ATOM 2261 C C   . ASP A 1 296 ? 64.753 -64.776  -16.285 1.00 56.07  ? 294 ASP A C   1 
ATOM 2262 O O   . ASP A 1 296 ? 65.885 -64.658  -16.745 1.00 52.38  ? 294 ASP A O   1 
ATOM 2263 C CB  . ASP A 1 296 ? 62.641 -64.182  -17.495 1.00 56.96  ? 294 ASP A CB  1 
ATOM 2264 C CG  . ASP A 1 296 ? 61.835 -64.382  -18.770 1.00 60.36  ? 294 ASP A CG  1 
ATOM 2265 O OD1 . ASP A 1 296 ? 61.836 -65.527  -19.303 1.00 53.84  ? 294 ASP A OD1 1 
ATOM 2266 O OD2 . ASP A 1 296 ? 61.235 -63.377  -19.236 1.00 60.23  ? 294 ASP A OD2 1 
ATOM 2267 N N   . LEU A 1 297 ? 64.443 -64.444  -15.030 1.00 55.11  ? 295 LEU A N   1 
ATOM 2268 C CA  . LEU A 1 297 ? 65.389 -63.777  -14.159 1.00 54.43  ? 295 LEU A CA  1 
ATOM 2269 C C   . LEU A 1 297 ? 66.596 -64.676  -13.944 1.00 54.81  ? 295 LEU A C   1 
ATOM 2270 O O   . LEU A 1 297 ? 67.728 -64.208  -13.970 1.00 63.69  ? 295 LEU A O   1 
ATOM 2271 C CB  . LEU A 1 297 ? 64.691 -63.422  -12.850 1.00 59.01  ? 295 LEU A CB  1 
ATOM 2272 C CG  . LEU A 1 297 ? 63.561 -62.389  -12.962 1.00 62.47  ? 295 LEU A CG  1 
ATOM 2273 C CD1 . LEU A 1 297 ? 62.819 -62.274  -11.640 1.00 64.11  ? 295 LEU A CD1 1 
ATOM 2274 C CD2 . LEU A 1 297 ? 64.035 -61.016  -13.420 1.00 60.07  ? 295 LEU A CD2 1 
ATOM 2275 N N   . ARG A 1 298 ? 66.341 -65.972  -13.788 1.00 57.30  ? 296 ARG A N   1 
ATOM 2276 C CA  . ARG A 1 298 ? 67.399 -66.952  -13.584 1.00 60.17  ? 296 ARG A CA  1 
ATOM 2277 C C   . ARG A 1 298 ? 68.354 -66.995  -14.779 1.00 61.50  ? 296 ARG A C   1 
ATOM 2278 O O   . ARG A 1 298 ? 69.568 -67.122  -14.606 1.00 58.46  ? 296 ARG A O   1 
ATOM 2279 C CB  . ARG A 1 298 ? 66.734 -68.295  -13.265 1.00 54.14  ? 296 ARG A CB  1 
ATOM 2280 C CG  . ARG A 1 298 ? 66.102 -68.233  -11.881 1.00 54.83  ? 296 ARG A CG  1 
ATOM 2281 C CD  . ARG A 1 298 ? 65.143 -69.361  -11.672 1.00 56.54  ? 296 ARG A CD  1 
ATOM 2282 N NE  . ARG A 1 298 ? 65.865 -70.578  -12.032 1.00 59.50  ? 296 ARG A NE  1 
ATOM 2283 C CZ  . ARG A 1 298 ? 65.533 -71.441  -12.958 1.00 66.78  ? 296 ARG A CZ  1 
ATOM 2284 N NH1 . ARG A 1 298 ? 64.311 -71.448  -13.447 1.00 70.31  ? 296 ARG A NH1 1 
ATOM 2285 N NH2 . ARG A 1 298 ? 66.427 -72.336  -13.343 1.00 68.25  ? 296 ARG A NH2 1 
ATOM 2286 N N   . LEU A 1 299 ? 67.787 -66.887  -15.983 1.00 65.43  ? 297 LEU A N   1 
ATOM 2287 C CA  . LEU A 1 299 ? 68.565 -66.794  -17.207 1.00 64.75  ? 297 LEU A CA  1 
ATOM 2288 C C   . LEU A 1 299 ? 69.430 -65.542  -17.202 1.00 66.57  ? 297 LEU A C   1 
ATOM 2289 O O   . LEU A 1 299 ? 70.644 -65.631  -17.376 1.00 62.73  ? 297 LEU A O   1 
ATOM 2290 C CB  . LEU A 1 299 ? 67.640 -66.741  -18.419 1.00 63.50  ? 297 LEU A CB  1 
ATOM 2291 C CG  . LEU A 1 299 ? 67.326 -68.063  -19.107 1.00 60.79  ? 297 LEU A CG  1 
ATOM 2292 C CD1 . LEU A 1 299 ? 66.356 -67.712  -20.232 1.00 67.94  ? 297 LEU A CD1 1 
ATOM 2293 C CD2 . LEU A 1 299 ? 68.580 -68.750  -19.624 1.00 61.32  ? 297 LEU A CD2 1 
ATOM 2294 N N   . MET A 1 300 ? 68.768 -64.382  -17.073 1.00 63.94  ? 298 MET A N   1 
ATOM 2295 C CA  . MET A 1 300 ? 69.433 -63.099  -17.197 1.00 64.81  ? 298 MET A CA  1 
ATOM 2296 C C   . MET A 1 300 ? 70.492 -62.979  -16.103 1.00 71.08  ? 298 MET A C   1 
ATOM 2297 O O   . MET A 1 300 ? 71.507 -62.311  -16.287 1.00 75.53  ? 298 MET A O   1 
ATOM 2298 C CB  . MET A 1 300 ? 68.423 -61.950  -17.129 1.00 65.59  ? 298 MET A CB  1 
ATOM 2299 C CG  . MET A 1 300 ? 67.679 -61.715  -18.423 1.00 71.56  ? 298 MET A CG  1 
ATOM 2300 S SD  . MET A 1 300 ? 66.683 -60.207  -18.436 1.00 74.70  ? 298 MET A SD  1 
ATOM 2301 C CE  . MET A 1 300 ? 65.397 -60.684  -17.272 1.00 80.06  ? 298 MET A CE  1 
ATOM 2302 N N   . ALA A 1 301 ? 70.289 -63.686  -14.989 1.00 69.38  ? 299 ALA A N   1 
ATOM 2303 C CA  . ALA A 1 301 ? 71.290 -63.696  -13.941 1.00 67.33  ? 299 ALA A CA  1 
ATOM 2304 C C   . ALA A 1 301 ? 72.207 -64.906  -14.085 1.00 66.36  ? 299 ALA A C   1 
ATOM 2305 O O   . ALA A 1 301 ? 72.853 -65.279  -13.127 1.00 66.88  ? 299 ALA A O   1 
ATOM 2306 C CB  . ALA A 1 301 ? 70.603 -63.663  -12.597 1.00 72.81  ? 299 ALA A CB  1 
ATOM 2307 N N   . SER A 1 302 ? 72.244 -65.551  -15.252 1.00 74.35  ? 300 SER A N   1 
ATOM 2308 C CA  . SER A 1 302 ? 73.189 -66.636  -15.457 1.00 83.53  ? 300 SER A CA  1 
ATOM 2309 C C   . SER A 1 302 ? 74.600 -66.053  -15.405 1.00 93.77  ? 300 SER A C   1 
ATOM 2310 O O   . SER A 1 302 ? 75.011 -65.325  -16.307 1.00 109.15 ? 300 SER A O   1 
ATOM 2311 C CB  . SER A 1 302 ? 72.954 -67.373  -16.764 1.00 87.00  ? 300 SER A CB  1 
ATOM 2312 O OG  . SER A 1 302 ? 72.906 -66.476  -17.869 1.00 93.32  ? 300 SER A OG  1 
ATOM 2313 N N   . GLY A 1 303 ? 75.333 -66.363  -14.338 1.00 103.58 ? 301 GLY A N   1 
ATOM 2314 C CA  . GLY A 1 303 ? 76.632 -65.764  -14.095 1.00 100.41 ? 301 GLY A CA  1 
ATOM 2315 C C   . GLY A 1 303 ? 77.457 -66.641  -13.168 1.00 94.66  ? 301 GLY A C   1 
ATOM 2316 O O   . GLY A 1 303 ? 77.013 -67.673  -12.697 1.00 85.93  ? 301 GLY A O   1 
ATOM 2317 N N   . PRO A 1 304 ? 78.710 -66.275  -12.879 1.00 96.24  ? 302 PRO A N   1 
ATOM 2318 C CA  . PRO A 1 304 ? 79.207 -64.922  -13.052 1.00 86.92  ? 302 PRO A CA  1 
ATOM 2319 C C   . PRO A 1 304 ? 79.747 -64.596  -14.440 1.00 89.39  ? 302 PRO A C   1 
ATOM 2320 O O   . PRO A 1 304 ? 79.518 -63.478  -14.895 1.00 83.43  ? 302 PRO A O   1 
ATOM 2321 C CB  . PRO A 1 304 ? 80.313 -64.919  -11.989 1.00 94.38  ? 302 PRO A CB  1 
ATOM 2322 C CG  . PRO A 1 304 ? 80.843 -66.327  -11.938 1.00 103.24 ? 302 PRO A CG  1 
ATOM 2323 C CD  . PRO A 1 304 ? 79.750 -67.200  -12.436 1.00 108.98 ? 302 PRO A CD  1 
ATOM 2324 N N   . ARG A 1 305 ? 80.443 -65.543  -15.094 1.00 87.69  ? 303 ARG A N   1 
ATOM 2325 C CA  . ARG A 1 305 ? 81.073 -65.250  -16.377 1.00 81.06  ? 303 ARG A CA  1 
ATOM 2326 C C   . ARG A 1 305 ? 80.460 -66.031  -17.540 1.00 75.01  ? 303 ARG A C   1 
ATOM 2327 O O   . ARG A 1 305 ? 80.124 -65.441  -18.557 1.00 76.38  ? 303 ARG A O   1 
ATOM 2328 C CB  . ARG A 1 305 ? 82.570 -65.541  -16.304 1.00 87.13  ? 303 ARG A CB  1 
ATOM 2329 C CG  . ARG A 1 305 ? 83.233 -65.104  -15.007 1.00 96.27  ? 303 ARG A CG  1 
ATOM 2330 C CD  . ARG A 1 305 ? 83.457 -63.607  -14.868 1.00 98.08  ? 303 ARG A CD  1 
ATOM 2331 N NE  . ARG A 1 305 ? 84.388 -63.294  -13.778 1.00 92.38  ? 303 ARG A NE  1 
ATOM 2332 C CZ  . ARG A 1 305 ? 85.682 -63.632  -13.709 1.00 87.82  ? 303 ARG A CZ  1 
ATOM 2333 N NH1 . ARG A 1 305 ? 86.311 -64.222  -14.714 1.00 87.31  ? 303 ARG A NH1 1 
ATOM 2334 N NH2 . ARG A 1 305 ? 86.376 -63.344  -12.625 1.00 81.22  ? 303 ARG A NH2 1 
ATOM 2335 N N   . ALA A 1 306 ? 80.284 -67.344  -17.388 1.00 75.76  ? 304 ALA A N   1 
ATOM 2336 C CA  . ALA A 1 306 ? 79.826 -68.201  -18.482 1.00 79.79  ? 304 ALA A CA  1 
ATOM 2337 C C   . ALA A 1 306 ? 78.296 -68.232  -18.622 1.00 74.45  ? 304 ALA A C   1 
ATOM 2338 O O   . ALA A 1 306 ? 77.668 -69.274  -18.499 1.00 71.38  ? 304 ALA A O   1 
ATOM 2339 C CB  . ALA A 1 306 ? 80.383 -69.595  -18.288 1.00 82.23  ? 304 ALA A CB  1 
ATOM 2340 N N   . GLY A 1 307 ? 77.701 -67.084  -18.926 1.00 68.96  ? 305 GLY A N   1 
ATOM 2341 C CA  . GLY A 1 307 ? 76.263 -66.953  -19.039 1.00 61.79  ? 305 GLY A CA  1 
ATOM 2342 C C   . GLY A 1 307 ? 75.903 -65.520  -19.430 1.00 67.55  ? 305 GLY A C   1 
ATOM 2343 O O   . GLY A 1 307 ? 76.785 -64.697  -19.682 1.00 69.01  ? 305 GLY A O   1 
ATOM 2344 N N   . LEU A 1 308 ? 74.600 -65.229  -19.457 1.00 70.34  ? 306 LEU A N   1 
ATOM 2345 C CA  . LEU A 1 308 ? 74.089 -63.959  -19.954 1.00 69.80  ? 306 LEU A CA  1 
ATOM 2346 C C   . LEU A 1 308 ? 74.632 -62.794  -19.119 1.00 69.65  ? 306 LEU A C   1 
ATOM 2347 O O   . LEU A 1 308 ? 75.152 -61.827  -19.667 1.00 71.00  ? 306 LEU A O   1 
ATOM 2348 C CB  . LEU A 1 308 ? 72.559 -64.005  -19.967 1.00 77.44  ? 306 LEU A CB  1 
ATOM 2349 C CG  . LEU A 1 308 ? 71.895 -64.589  -21.223 1.00 88.92  ? 306 LEU A CG  1 
ATOM 2350 C CD1 . LEU A 1 308 ? 72.472 -65.913  -21.672 1.00 93.79  ? 306 LEU A CD1 1 
ATOM 2351 C CD2 . LEU A 1 308 ? 70.399 -64.759  -21.035 1.00 91.53  ? 306 LEU A CD2 1 
ATOM 2352 N N   . GLY A 1 309 ? 74.492 -62.889  -17.791 1.00 62.89  ? 307 GLY A N   1 
ATOM 2353 C CA  . GLY A 1 309 ? 75.037 -61.899  -16.880 1.00 65.60  ? 307 GLY A CA  1 
ATOM 2354 C C   . GLY A 1 309 ? 74.495 -60.493  -17.134 1.00 69.06  ? 307 GLY A C   1 
ATOM 2355 O O   . GLY A 1 309 ? 75.234 -59.515  -17.022 1.00 75.82  ? 307 GLY A O   1 
ATOM 2356 N N   . GLU A 1 310 ? 73.202 -60.409  -17.461 1.00 73.93  ? 308 GLU A N   1 
ATOM 2357 C CA  . GLU A 1 310 ? 72.552 -59.141  -17.761 1.00 81.78  ? 308 GLU A CA  1 
ATOM 2358 C C   . GLU A 1 310 ? 72.069 -58.452  -16.479 1.00 74.85  ? 308 GLU A C   1 
ATOM 2359 O O   . GLU A 1 310 ? 71.939 -57.231  -16.455 1.00 63.90  ? 308 GLU A O   1 
ATOM 2360 C CB  . GLU A 1 310 ? 71.382 -59.328  -18.733 1.00 86.36  ? 308 GLU A CB  1 
ATOM 2361 C CG  . GLU A 1 310 ? 71.796 -59.649  -20.166 1.00 91.79  ? 308 GLU A CG  1 
ATOM 2362 C CD  . GLU A 1 310 ? 70.649 -59.607  -21.173 1.00 95.64  ? 308 GLU A CD  1 
ATOM 2363 O OE1 . GLU A 1 310 ? 70.893 -59.323  -22.383 1.00 101.61 ? 308 GLU A OE1 1 
ATOM 2364 O OE2 . GLU A 1 310 ? 69.505 -59.880  -20.747 1.00 80.88  ? 308 GLU A OE2 1 
ATOM 2365 N N   . ILE A 1 311 ? 71.764 -59.233  -15.431 1.00 75.58  ? 309 ILE A N   1 
ATOM 2366 C CA  . ILE A 1 311 ? 71.341 -58.675  -14.152 1.00 77.55  ? 309 ILE A CA  1 
ATOM 2367 C C   . ILE A 1 311 ? 72.032 -59.431  -13.013 1.00 84.59  ? 309 ILE A C   1 
ATOM 2368 O O   . ILE A 1 311 ? 72.809 -60.368  -13.239 1.00 79.28  ? 309 ILE A O   1 
ATOM 2369 C CB  . ILE A 1 311 ? 69.804 -58.686  -13.993 1.00 71.64  ? 309 ILE A CB  1 
ATOM 2370 C CG1 . ILE A 1 311 ? 69.238 -60.105  -13.919 1.00 70.57  ? 309 ILE A CG1 1 
ATOM 2371 C CG2 . ILE A 1 311 ? 69.120 -57.878  -15.093 1.00 69.03  ? 309 ILE A CG2 1 
ATOM 2372 C CD1 . ILE A 1 311 ? 67.743 -60.161  -13.672 1.00 68.05  ? 309 ILE A CD1 1 
ATOM 2373 N N   . THR A 1 312 ? 71.768 -58.951  -11.786 1.00 83.83  ? 310 THR A N   1 
ATOM 2374 C CA  . THR A 1 312 ? 72.208 -59.590  -10.555 1.00 80.08  ? 310 THR A CA  1 
ATOM 2375 C C   . THR A 1 312 ? 71.074 -59.517  -9.541  1.00 79.38  ? 310 THR A C   1 
ATOM 2376 O O   . THR A 1 312 ? 70.447 -58.466  -9.381  1.00 88.95  ? 310 THR A O   1 
ATOM 2377 C CB  . THR A 1 312 ? 73.448 -58.891  -10.004 1.00 80.34  ? 310 THR A CB  1 
ATOM 2378 O OG1 . THR A 1 312 ? 73.044 -57.523  -9.969  1.00 72.25  ? 310 THR A OG1 1 
ATOM 2379 C CG2 . THR A 1 312 ? 74.690 -59.119  -10.853 1.00 84.55  ? 310 THR A CG2 1 
ATOM 2380 N N   . LEU A 1 313 ? 70.836 -60.642  -8.866  1.00 72.98  ? 311 LEU A N   1 
ATOM 2381 C CA  . LEU A 1 313 ? 69.812 -60.700  -7.840  1.00 72.38  ? 311 LEU A CA  1 
ATOM 2382 C C   . LEU A 1 313 ? 70.495 -60.730  -6.477  1.00 69.72  ? 311 LEU A C   1 
ATOM 2383 O O   . LEU A 1 313 ? 71.487 -61.430  -6.314  1.00 61.66  ? 311 LEU A O   1 
ATOM 2384 C CB  . LEU A 1 313 ? 68.933 -61.936  -7.998  1.00 72.15  ? 311 LEU A CB  1 
ATOM 2385 C CG  . LEU A 1 313 ? 68.433 -62.283  -9.398  1.00 66.13  ? 311 LEU A CG  1 
ATOM 2386 C CD1 . LEU A 1 313 ? 67.622 -63.578  -9.301  1.00 57.31  ? 311 LEU A CD1 1 
ATOM 2387 C CD2 . LEU A 1 313 ? 67.636 -61.127  -9.960  1.00 65.88  ? 311 LEU A CD2 1 
ATOM 2388 N N   . PRO A 1 314 ? 69.941 -60.047  -5.448  1.00 68.82  ? 312 PRO A N   1 
ATOM 2389 C CA  . PRO A 1 314 ? 70.501 -60.075  -4.099  1.00 67.54  ? 312 PRO A CA  1 
ATOM 2390 C C   . PRO A 1 314 ? 70.893 -61.475  -3.662  1.00 72.93  ? 312 PRO A C   1 
ATOM 2391 O O   . PRO A 1 314 ? 70.074 -62.382  -3.746  1.00 88.83  ? 312 PRO A O   1 
ATOM 2392 C CB  . PRO A 1 314 ? 69.346 -59.539  -3.253  1.00 66.35  ? 312 PRO A CB  1 
ATOM 2393 C CG  . PRO A 1 314 ? 68.655 -58.562  -4.165  1.00 66.17  ? 312 PRO A CG  1 
ATOM 2394 C CD  . PRO A 1 314 ? 68.724 -59.225  -5.529  1.00 71.47  ? 312 PRO A CD  1 
ATOM 2395 N N   . ALA A 1 315 ? 72.145 -61.634  -3.215  1.00 80.22  ? 313 ALA A N   1 
ATOM 2396 C CA  . ALA A 1 315 ? 72.563 -62.847  -2.529  1.00 76.52  ? 313 ALA A CA  1 
ATOM 2397 C C   . ALA A 1 315 ? 71.758 -62.935  -1.243  1.00 65.88  ? 313 ALA A C   1 
ATOM 2398 O O   . ALA A 1 315 ? 71.551 -61.914  -0.579  1.00 52.16  ? 313 ALA A O   1 
ATOM 2399 C CB  . ALA A 1 315 ? 74.040 -62.815  -2.218  1.00 79.98  ? 313 ALA A CB  1 
ATOM 2400 N N   . ARG A 1 316 ? 71.268 -64.143  -0.940  1.00 58.89  ? 314 ARG A N   1 
ATOM 2401 C CA  . ARG A 1 316 ? 70.513 -64.344  0.286   1.00 61.31  ? 314 ARG A CA  1 
ATOM 2402 C C   . ARG A 1 316 ? 71.117 -65.484  1.095   1.00 61.98  ? 314 ARG A C   1 
ATOM 2403 O O   . ARG A 1 316 ? 70.730 -65.714  2.235   1.00 64.23  ? 314 ARG A O   1 
ATOM 2404 C CB  . ARG A 1 316 ? 69.031 -64.625  0.024   1.00 57.89  ? 314 ARG A CB  1 
ATOM 2405 C CG  . ARG A 1 316 ? 68.281 -63.455  -0.596  1.00 58.55  ? 314 ARG A CG  1 
ATOM 2406 C CD  . ARG A 1 316 ? 68.240 -62.191  0.226   1.00 56.62  ? 314 ARG A CD  1 
ATOM 2407 N NE  . ARG A 1 316 ? 67.547 -62.441  1.489   1.00 62.58  ? 314 ARG A NE  1 
ATOM 2408 C CZ  . ARG A 1 316 ? 67.158 -61.480  2.323   1.00 71.20  ? 314 ARG A CZ  1 
ATOM 2409 N NH1 . ARG A 1 316 ? 67.397 -60.214  2.029   1.00 75.35  ? 314 ARG A NH1 1 
ATOM 2410 N NH2 . ARG A 1 316 ? 66.513 -61.778  3.437   1.00 75.29  ? 314 ARG A NH2 1 
ATOM 2411 N N   . GLN A 1 317 ? 72.060 -66.211  0.506   1.00 64.52  ? 315 GLN A N   1 
ATOM 2412 C CA  . GLN A 1 317 ? 72.690 -67.292  1.229   1.00 70.88  ? 315 GLN A CA  1 
ATOM 2413 C C   . GLN A 1 317 ? 73.902 -67.766  0.446   1.00 74.03  ? 315 GLN A C   1 
ATOM 2414 O O   . GLN A 1 317 ? 74.017 -67.479  -0.736  1.00 79.60  ? 315 GLN A O   1 
ATOM 2415 C CB  . GLN A 1 317 ? 71.695 -68.417  1.523   1.00 73.38  ? 315 GLN A CB  1 
ATOM 2416 C CG  . GLN A 1 317 ? 70.880 -68.914  0.334   1.00 72.11  ? 315 GLN A CG  1 
ATOM 2417 C CD  . GLN A 1 317 ? 70.103 -70.185  0.621   1.00 74.54  ? 315 GLN A CD  1 
ATOM 2418 O OE1 . GLN A 1 317 ? 70.292 -71.209  -0.051  1.00 83.21  ? 315 GLN A OE1 1 
ATOM 2419 N NE2 . GLN A 1 317 ? 69.228 -70.137  1.622   1.00 67.40  ? 315 GLN A NE2 1 
ATOM 2420 N N   . PRO A 1 318 ? 74.851 -68.482  1.089   1.00 86.18  ? 316 PRO A N   1 
ATOM 2421 C CA  . PRO A 1 318 ? 75.885 -69.203  0.348   1.00 89.03  ? 316 PRO A CA  1 
ATOM 2422 C C   . PRO A 1 318 ? 75.147 -70.155  -0.581  1.00 93.39  ? 316 PRO A C   1 
ATOM 2423 O O   . PRO A 1 318 ? 74.355 -70.966  -0.107  1.00 104.16 ? 316 PRO A O   1 
ATOM 2424 C CB  . PRO A 1 318 ? 76.702 -69.928  1.424   1.00 93.30  ? 316 PRO A CB  1 
ATOM 2425 C CG  . PRO A 1 318 ? 76.367 -69.198  2.721   1.00 92.88  ? 316 PRO A CG  1 
ATOM 2426 C CD  . PRO A 1 318 ? 74.966 -68.645  2.550   1.00 91.12  ? 316 PRO A CD  1 
ATOM 2427 N N   . GLY A 1 319 ? 75.367 -70.019  -1.895  1.00 91.40  ? 317 GLY A N   1 
ATOM 2428 C CA  . GLY A 1 319 ? 74.569 -70.726  -2.886  1.00 99.23  ? 317 GLY A CA  1 
ATOM 2429 C C   . GLY A 1 319 ? 74.864 -72.225  -2.883  1.00 101.27 ? 317 GLY A C   1 
ATOM 2430 O O   . GLY A 1 319 ? 73.942 -73.039  -3.021  1.00 92.81  ? 317 GLY A O   1 
ATOM 2431 N N   . SER A 1 320 ? 76.157 -72.548  -2.695  1.00 104.53 ? 318 SER A N   1 
ATOM 2432 C CA  . SER A 1 320 ? 76.676 -73.908  -2.745  1.00 106.31 ? 318 SER A CA  1 
ATOM 2433 C C   . SER A 1 320 ? 77.595 -74.180  -1.557  1.00 97.52  ? 318 SER A C   1 
ATOM 2434 O O   . SER A 1 320 ? 78.147 -73.259  -0.958  1.00 78.11  ? 318 SER A O   1 
ATOM 2435 C CB  . SER A 1 320 ? 77.427 -74.182  -4.041  1.00 113.30 ? 318 SER A CB  1 
ATOM 2436 O OG  . SER A 1 320 ? 78.031 -75.469  -4.067  1.00 110.93 ? 318 SER A OG  1 
ATOM 2437 N N   . SER A 1 321 ? 77.795 -75.483  -1.310  1.00 113.44 ? 319 SER A N   1 
ATOM 2438 C CA  . SER A 1 321 ? 78.550 -76.013  -0.186  1.00 113.03 ? 319 SER A CA  1 
ATOM 2439 C C   . SER A 1 321 ? 80.005 -76.315  -0.568  1.00 106.12 ? 319 SER A C   1 
ATOM 2440 O O   . SER A 1 321 ? 80.876 -76.278  0.301   1.00 92.17  ? 319 SER A O   1 
ATOM 2441 C CB  . SER A 1 321 ? 77.845 -77.242  0.383   1.00 114.09 ? 319 SER A CB  1 
ATOM 2442 O OG  . SER A 1 321 ? 77.319 -78.085  -0.641  1.00 109.57 ? 319 SER A OG  1 
ATOM 2443 N N   . ILE A 1 322 ? 80.275 -76.619  -1.853  1.00 108.68 ? 320 ILE A N   1 
ATOM 2444 C CA  . ILE A 1 322 ? 81.608 -76.999  -2.312  1.00 107.91 ? 320 ILE A CA  1 
ATOM 2445 C C   . ILE A 1 322 ? 82.219 -75.959  -3.263  1.00 103.09 ? 320 ILE A C   1 
ATOM 2446 O O   . ILE A 1 322 ? 83.437 -75.769  -3.250  1.00 99.59  ? 320 ILE A O   1 
ATOM 2447 C CB  . ILE A 1 322 ? 81.579 -78.395  -2.961  1.00 104.05 ? 320 ILE A CB  1 
ATOM 2448 C CG1 . ILE A 1 322 ? 82.989 -78.890  -3.283  1.00 103.08 ? 320 ILE A CG1 1 
ATOM 2449 C CG2 . ILE A 1 322 ? 80.674 -78.402  -4.195  1.00 109.18 ? 320 ILE A CG2 1 
ATOM 2450 C CD1 . ILE A 1 322 ? 83.092 -80.389  -3.522  1.00 100.41 ? 320 ILE A CD1 1 
ATOM 2451 N N   . ILE A 1 323 ? 81.404 -75.292  -4.099  1.00 92.88  ? 321 ILE A N   1 
ATOM 2452 C CA  . ILE A 1 323 ? 81.939 -74.283  -5.002  1.00 84.97  ? 321 ILE A CA  1 
ATOM 2453 C C   . ILE A 1 323 ? 82.066 -72.965  -4.243  1.00 81.90  ? 321 ILE A C   1 
ATOM 2454 O O   . ILE A 1 323 ? 81.060 -72.403  -3.823  1.00 79.08  ? 321 ILE A O   1 
ATOM 2455 C CB  . ILE A 1 323 ? 81.098 -74.106  -6.282  1.00 77.53  ? 321 ILE A CB  1 
ATOM 2456 C CG1 . ILE A 1 323 ? 80.982 -75.393  -7.088  1.00 74.89  ? 321 ILE A CG1 1 
ATOM 2457 C CG2 . ILE A 1 323 ? 81.675 -72.987  -7.150  1.00 80.64  ? 321 ILE A CG2 1 
ATOM 2458 C CD1 . ILE A 1 323 ? 79.628 -76.061  -7.002  1.00 79.66  ? 321 ILE A CD1 1 
ATOM 2459 N N   . PRO A 1 324 ? 83.294 -72.420  -4.066  1.00 90.14  ? 322 PRO A N   1 
ATOM 2460 C CA  . PRO A 1 324 ? 83.469 -71.099  -3.464  1.00 90.45  ? 322 PRO A CA  1 
ATOM 2461 C C   . PRO A 1 324 ? 82.958 -69.972  -4.360  1.00 79.69  ? 322 PRO A C   1 
ATOM 2462 O O   . PRO A 1 324 ? 83.285 -69.910  -5.542  1.00 71.55  ? 322 PRO A O   1 
ATOM 2463 C CB  . PRO A 1 324 ? 84.996 -71.011  -3.228  1.00 97.75  ? 322 PRO A CB  1 
ATOM 2464 C CG  . PRO A 1 324 ? 85.500 -72.433  -3.373  1.00 92.94  ? 322 PRO A CG  1 
ATOM 2465 C CD  . PRO A 1 324 ? 84.584 -73.049  -4.401  1.00 92.92  ? 322 PRO A CD  1 
ATOM 2466 N N   . GLY A 1 325 ? 82.186 -69.059  -3.775  1.00 82.71  ? 323 GLY A N   1 
ATOM 2467 C CA  . GLY A 1 325 ? 81.747 -67.874  -4.531  1.00 93.86  ? 323 GLY A CA  1 
ATOM 2468 C C   . GLY A 1 325 ? 80.402 -68.078  -5.179  1.00 98.79  ? 323 GLY A C   1 
ATOM 2469 O O   . GLY A 1 325 ? 79.930 -67.151  -5.864  1.00 119.62 ? 323 GLY A O   1 
ATOM 2470 N N   . MET A 1 326 ? 79.788 -69.233  -4.958  1.00 90.39  ? 324 MET A N   1 
ATOM 2471 C CA  . MET A 1 326 ? 78.524 -69.519  -5.673  1.00 98.59  ? 324 MET A CA  1 
ATOM 2472 C C   . MET A 1 326 ? 77.367 -68.757  -5.026  1.00 101.70 ? 324 MET A C   1 
ATOM 2473 O O   . MET A 1 326 ? 77.088 -69.006  -3.839  1.00 87.44  ? 324 MET A O   1 
ATOM 2474 C CB  . MET A 1 326 ? 78.220 -71.016  -5.651  1.00 30.00  ? 324 MET A CB  1 
ATOM 2475 C CG  . MET A 1 326 ? 76.980 -71.392  -6.419  1.00 30.00  ? 324 MET A CG  1 
ATOM 2476 S SD  . MET A 1 326 ? 77.413 -72.016  -8.052  1.00 30.00  ? 324 MET A SD  1 
ATOM 2477 C CE  . MET A 1 326 ? 76.634 -73.634  -7.969  1.00 30.00  ? 324 MET A CE  1 
ATOM 2478 N N   . VAL A 1 327 ? 76.748 -67.844  -5.773  1.00 108.56 ? 325 VAL A N   1 
ATOM 2479 C CA  . VAL A 1 327 ? 75.529 -67.144  -5.277  1.00 95.45  ? 325 VAL A CA  1 
ATOM 2480 C C   . VAL A 1 327 ? 74.409 -67.558  -6.235  1.00 89.81  ? 325 VAL A C   1 
ATOM 2481 O O   . VAL A 1 327 ? 74.532 -67.261  -7.436  1.00 89.59  ? 325 VAL A O   1 
ATOM 2482 C CB  . VAL A 1 327 ? 75.681 -65.617  -5.222  1.00 87.44  ? 325 VAL A CB  1 
ATOM 2483 C CG1 . VAL A 1 327 ? 74.331 -64.914  -5.190  1.00 89.11  ? 325 VAL A CG1 1 
ATOM 2484 C CG2 . VAL A 1 327 ? 76.541 -65.189  -4.041  1.00 88.18  ? 325 VAL A CG2 1 
ATOM 2485 N N   . CYS A 1 328 ? 73.381 -68.235  -5.728  1.00 79.02  ? 326 CYS A N   1 
ATOM 2486 C CA  . CYS A 1 328 ? 72.325 -68.771  -6.617  1.00 71.01  ? 326 CYS A CA  1 
ATOM 2487 C C   . CYS A 1 328 ? 71.060 -67.904  -6.561  1.00 71.73  ? 326 CYS A C   1 
ATOM 2488 O O   . CYS A 1 328 ? 70.845 -67.219  -5.545  1.00 65.02  ? 326 CYS A O   1 
ATOM 2489 C CB  . CYS A 1 328 ? 72.030 -70.204  -6.207  1.00 72.57  ? 326 CYS A CB  1 
ATOM 2490 S SG  . CYS A 1 328 ? 73.431 -71.319  -6.467  1.00 92.87  ? 326 CYS A SG  1 
ATOM 2491 N N   . PRO A 1 329 ? 70.225 -67.905  -7.619  1.00 78.35  ? 327 PRO A N   1 
ATOM 2492 C CA  . PRO A 1 329 ? 68.977 -67.147  -7.623  1.00 79.17  ? 327 PRO A CA  1 
ATOM 2493 C C   . PRO A 1 329 ? 67.918 -67.890  -6.819  1.00 69.96  ? 327 PRO A C   1 
ATOM 2494 O O   . PRO A 1 329 ? 66.921 -68.330  -7.372  1.00 69.52  ? 327 PRO A O   1 
ATOM 2495 C CB  . PRO A 1 329 ? 68.689 -67.103  -9.141  1.00 81.57  ? 327 PRO A CB  1 
ATOM 2496 C CG  . PRO A 1 329 ? 69.181 -68.438  -9.663  1.00 74.20  ? 327 PRO A CG  1 
ATOM 2497 C CD  . PRO A 1 329 ? 70.440 -68.675  -8.859  1.00 76.08  ? 327 PRO A CD  1 
ATOM 2498 N N   . VAL A 1 330 ? 68.135 -68.029  -5.513  1.00 68.24  ? 328 VAL A N   1 
ATOM 2499 C CA  . VAL A 1 330 ? 67.321 -68.952  -4.738  1.00 75.06  ? 328 VAL A CA  1 
ATOM 2500 C C   . VAL A 1 330 ? 65.920 -68.381  -4.530  1.00 74.52  ? 328 VAL A C   1 
ATOM 2501 O O   . VAL A 1 330 ? 64.974 -69.129  -4.303  1.00 75.13  ? 328 VAL A O   1 
ATOM 2502 C CB  . VAL A 1 330 ? 67.915 -69.334  -3.375  1.00 67.01  ? 328 VAL A CB  1 
ATOM 2503 C CG1 . VAL A 1 330 ? 69.306 -69.925  -3.515  1.00 70.40  ? 328 VAL A CG1 1 
ATOM 2504 C CG2 . VAL A 1 330 ? 67.894 -68.144  -2.436  1.00 65.73  ? 328 VAL A CG2 1 
ATOM 2505 N N   . MET A 1 331 ? 65.773 -67.061  -4.572  1.00 69.92  ? 329 MET A N   1 
ATOM 2506 C CA  . MET A 1 331 ? 64.452 -66.496  -4.391  1.00 70.17  ? 329 MET A CA  1 
ATOM 2507 C C   . MET A 1 331 ? 63.554 -66.855  -5.577  1.00 72.62  ? 329 MET A C   1 
ATOM 2508 O O   . MET A 1 331 ? 62.418 -67.288  -5.399  1.00 65.24  ? 329 MET A O   1 
ATOM 2509 C CB  . MET A 1 331 ? 64.562 -64.990  -4.154  1.00 72.63  ? 329 MET A CB  1 
ATOM 2510 C CG  . MET A 1 331 ? 65.295 -64.649  -2.869  1.00 75.24  ? 329 MET A CG  1 
ATOM 2511 S SD  . MET A 1 331 ? 64.880 -65.655  -1.425  1.00 67.59  ? 329 MET A SD  1 
ATOM 2512 C CE  . MET A 1 331 ? 63.179 -65.169  -1.114  1.00 63.23  ? 329 MET A CE  1 
ATOM 2513 N N   . ALA A 1 332 ? 64.070 -66.705  -6.800  1.00 78.36  ? 330 ALA A N   1 
ATOM 2514 C CA  . ALA A 1 332 ? 63.335 -67.127  -7.985  1.00 72.04  ? 330 ALA A CA  1 
ATOM 2515 C C   . ALA A 1 332 ? 63.036 -68.625  -7.922  1.00 64.77  ? 330 ALA A C   1 
ATOM 2516 O O   . ALA A 1 332 ? 61.928 -69.052  -8.229  1.00 59.66  ? 330 ALA A O   1 
ATOM 2517 C CB  . ALA A 1 332 ? 64.115 -66.783  -9.234  1.00 72.66  ? 330 ALA A CB  1 
ATOM 2518 N N   . GLU A 1 333 ? 64.033 -69.417  -7.514  1.00 62.43  ? 331 GLU A N   1 
ATOM 2519 C CA  . GLU A 1 333 ? 63.910 -70.864  -7.506  1.00 62.93  ? 331 GLU A CA  1 
ATOM 2520 C C   . GLU A 1 333 ? 62.716 -71.257  -6.658  1.00 59.59  ? 331 GLU A C   1 
ATOM 2521 O O   . GLU A 1 333 ? 61.995 -72.185  -6.995  1.00 64.13  ? 331 GLU A O   1 
ATOM 2522 C CB  . GLU A 1 333 ? 65.149 -71.585  -6.966  1.00 66.14  ? 331 GLU A CB  1 
ATOM 2523 C CG  . GLU A 1 333 ? 66.352 -71.433  -7.894  1.00 70.65  ? 331 GLU A CG  1 
ATOM 2524 C CD  . GLU A 1 333 ? 67.641 -72.093  -7.477  1.00 69.66  ? 331 GLU A CD  1 
ATOM 2525 O OE1 . GLU A 1 333 ? 67.653 -72.726  -6.397  1.00 81.58  ? 331 GLU A OE1 1 
ATOM 2526 O OE2 . GLU A 1 333 ? 68.606 -71.951  -8.260  1.00 59.69  ? 331 GLU A OE2 1 
ATOM 2527 N N   . VAL A 1 334 ? 62.519 -70.560  -5.543  1.00 59.31  ? 332 VAL A N   1 
ATOM 2528 C CA  . VAL A 1 334 ? 61.473 -70.977  -4.634  1.00 60.58  ? 332 VAL A CA  1 
ATOM 2529 C C   . VAL A 1 334 ? 60.143 -70.682  -5.325  1.00 61.10  ? 332 VAL A C   1 
ATOM 2530 O O   . VAL A 1 334 ? 59.219 -71.492  -5.247  1.00 67.83  ? 332 VAL A O   1 
ATOM 2531 C CB  . VAL A 1 334 ? 61.588 -70.375  -3.217  1.00 59.52  ? 332 VAL A CB  1 
ATOM 2532 C CG1 . VAL A 1 334 ? 61.105 -68.937  -3.142  1.00 61.36  ? 332 VAL A CG1 1 
ATOM 2533 C CG2 . VAL A 1 334 ? 60.859 -71.221  -2.183  1.00 62.95  ? 332 VAL A CG2 1 
ATOM 2534 N N   . ILE A 1 335 ? 60.078 -69.565  -6.063  1.00 55.91  ? 333 ILE A N   1 
ATOM 2535 C CA  . ILE A 1 335 ? 58.882 -69.230  -6.821  1.00 54.57  ? 333 ILE A CA  1 
ATOM 2536 C C   . ILE A 1 335 ? 58.559 -70.351  -7.816  1.00 54.58  ? 333 ILE A C   1 
ATOM 2537 O O   . ILE A 1 335 ? 57.417 -70.801  -7.891  1.00 50.96  ? 333 ILE A O   1 
ATOM 2538 C CB  . ILE A 1 335 ? 59.035 -67.858  -7.506  1.00 52.54  ? 333 ILE A CB  1 
ATOM 2539 C CG1 . ILE A 1 335 ? 58.901 -66.716  -6.534  1.00 52.74  ? 333 ILE A CG1 1 
ATOM 2540 C CG2 . ILE A 1 335 ? 58.019 -67.701  -8.631  1.00 57.70  ? 333 ILE A CG2 1 
ATOM 2541 C CD1 . ILE A 1 335 ? 57.469 -66.478  -6.082  1.00 57.14  ? 333 ILE A CD1 1 
ATOM 2542 N N   . ASN A 1 336 ? 59.558 -70.793  -8.593  1.00 59.57  ? 334 ASN A N   1 
ATOM 2543 C CA  . ASN A 1 336 ? 59.380 -71.902  -9.524  1.00 65.31  ? 334 ASN A CA  1 
ATOM 2544 C C   . ASN A 1 336 ? 58.704 -73.072  -8.811  1.00 62.96  ? 334 ASN A C   1 
ATOM 2545 O O   . ASN A 1 336 ? 57.711 -73.604  -9.300  1.00 61.16  ? 334 ASN A O   1 
ATOM 2546 C CB  . ASN A 1 336 ? 60.692 -72.352  -10.170 1.00 65.08  ? 334 ASN A CB  1 
ATOM 2547 C CG  . ASN A 1 336 ? 61.206 -71.390  -11.225 1.00 60.88  ? 334 ASN A CG  1 
ATOM 2548 O OD1 . ASN A 1 336 ? 60.487 -71.047  -12.174 1.00 59.80  ? 334 ASN A OD1 1 
ATOM 2549 N ND2 . ASN A 1 336 ? 62.451 -70.950  -11.094 1.00 55.79  ? 334 ASN A ND2 1 
ATOM 2550 N N   . GLN A 1 337 ? 59.242 -73.441  -7.643  1.00 64.62  ? 335 GLN A N   1 
ATOM 2551 C CA  . GLN A 1 337 ? 58.825 -74.643  -6.939  1.00 65.48  ? 335 GLN A CA  1 
ATOM 2552 C C   . GLN A 1 337 ? 57.402 -74.497  -6.430  1.00 60.10  ? 335 GLN A C   1 
ATOM 2553 O O   . GLN A 1 337 ? 56.632 -75.442  -6.500  1.00 57.54  ? 335 GLN A O   1 
ATOM 2554 C CB  . GLN A 1 337 ? 59.701 -74.976  -5.735  1.00 68.75  ? 335 GLN A CB  1 
ATOM 2555 C CG  . GLN A 1 337 ? 61.126 -75.348  -6.123  1.00 74.20  ? 335 GLN A CG  1 
ATOM 2556 C CD  . GLN A 1 337 ? 61.915 -75.960  -4.989  1.00 75.07  ? 335 GLN A CD  1 
ATOM 2557 O OE1 . GLN A 1 337 ? 61.488 -76.960  -4.396  1.00 70.81  ? 335 GLN A OE1 1 
ATOM 2558 N NE2 . GLN A 1 337 ? 63.077 -75.377  -4.703  1.00 74.35  ? 335 GLN A NE2 1 
ATOM 2559 N N   . ILE A 1 338 ? 57.087 -73.318  -5.892  1.00 63.87  ? 336 ILE A N   1 
ATOM 2560 C CA  . ILE A 1 338 ? 55.731 -73.001  -5.482  1.00 69.50  ? 336 ILE A CA  1 
ATOM 2561 C C   . ILE A 1 338 ? 54.765 -73.213  -6.648  1.00 70.33  ? 336 ILE A C   1 
ATOM 2562 O O   . ILE A 1 338 ? 53.721 -73.841  -6.478  1.00 64.82  ? 336 ILE A O   1 
ATOM 2563 C CB  . ILE A 1 338 ? 55.665 -71.565  -4.939  1.00 74.14  ? 336 ILE A CB  1 
ATOM 2564 C CG1 . ILE A 1 338 ? 56.287 -71.494  -3.552  1.00 75.43  ? 336 ILE A CG1 1 
ATOM 2565 C CG2 . ILE A 1 338 ? 54.227 -71.043  -4.947  1.00 77.57  ? 336 ILE A CG2 1 
ATOM 2566 C CD1 . ILE A 1 338 ? 56.531 -70.085  -3.050  1.00 77.53  ? 336 ILE A CD1 1 
ATOM 2567 N N   . ALA A 1 339 ? 55.109 -72.666  -7.821  1.00 67.32  ? 337 ALA A N   1 
ATOM 2568 C CA  . ALA A 1 339 ? 54.242 -72.790  -8.978  1.00 62.57  ? 337 ALA A CA  1 
ATOM 2569 C C   . ALA A 1 339 ? 53.897 -74.258  -9.198  1.00 52.43  ? 337 ALA A C   1 
ATOM 2570 O O   . ALA A 1 339 ? 52.727 -74.603  -9.314  1.00 58.01  ? 337 ALA A O   1 
ATOM 2571 C CB  . ALA A 1 339 ? 54.883 -72.179  -10.193 1.00 63.93  ? 337 ALA A CB  1 
ATOM 2572 N N   . PHE A 1 340 ? 54.911 -75.116  -9.165  1.00 45.82  ? 338 PHE A N   1 
ATOM 2573 C CA  . PHE A 1 340 ? 54.705 -76.538  -9.388  1.00 55.54  ? 338 PHE A CA  1 
ATOM 2574 C C   . PHE A 1 340 ? 53.712 -77.123  -8.375  1.00 54.68  ? 338 PHE A C   1 
ATOM 2575 O O   . PHE A 1 340 ? 52.908 -77.980  -8.726  1.00 56.24  ? 338 PHE A O   1 
ATOM 2576 C CB  . PHE A 1 340 ? 56.042 -77.292  -9.347  1.00 60.71  ? 338 PHE A CB  1 
ATOM 2577 C CG  . PHE A 1 340 ? 57.129 -76.769  -10.278 1.00 58.34  ? 338 PHE A CG  1 
ATOM 2578 C CD1 . PHE A 1 340 ? 56.825 -75.949  -11.355 1.00 55.20  ? 338 PHE A CD1 1 
ATOM 2579 C CD2 . PHE A 1 340 ? 58.458 -77.109  -10.071 1.00 61.63  ? 338 PHE A CD2 1 
ATOM 2580 C CE1 . PHE A 1 340 ? 57.820 -75.467  -12.184 1.00 53.45  ? 338 PHE A CE1 1 
ATOM 2581 C CE2 . PHE A 1 340 ? 59.447 -76.624  -10.910 1.00 65.97  ? 338 PHE A CE2 1 
ATOM 2582 C CZ  . PHE A 1 340 ? 59.122 -75.803  -11.964 1.00 59.61  ? 338 PHE A CZ  1 
ATOM 2583 N N   . GLN A 1 341 ? 53.784 -76.687  -7.116  1.00 57.57  ? 339 GLN A N   1 
ATOM 2584 C CA  . GLN A 1 341 ? 52.801 -77.068  -6.115  1.00 61.63  ? 339 GLN A CA  1 
ATOM 2585 C C   . GLN A 1 341 ? 51.413 -76.645  -6.565  1.00 67.32  ? 339 GLN A C   1 
ATOM 2586 O O   . GLN A 1 341 ? 50.542 -77.499  -6.709  1.00 75.28  ? 339 GLN A O   1 
ATOM 2587 C CB  . GLN A 1 341 ? 52.958 -76.370  -4.762  1.00 65.04  ? 339 GLN A CB  1 
ATOM 2588 C CG  . GLN A 1 341 ? 53.780 -77.150  -3.746  1.00 65.81  ? 339 GLN A CG  1 
ATOM 2589 C CD  . GLN A 1 341 ? 53.155 -78.469  -3.378  1.00 64.57  ? 339 GLN A CD  1 
ATOM 2590 O OE1 . GLN A 1 341 ? 53.830 -79.502  -3.305  1.00 62.64  ? 339 GLN A OE1 1 
ATOM 2591 N NE2 . GLN A 1 341 ? 51.855 -78.424  -3.130  1.00 69.62  ? 339 GLN A NE2 1 
ATOM 2592 N N   . VAL A 1 342 ? 51.241 -75.326  -6.773  1.00 61.66  ? 340 VAL A N   1 
ATOM 2593 C CA  . VAL A 1 342 ? 49.932 -74.727  -6.974  1.00 65.24  ? 340 VAL A CA  1 
ATOM 2594 C C   . VAL A 1 342 ? 49.189 -75.471  -8.078  1.00 67.92  ? 340 VAL A C   1 
ATOM 2595 O O   . VAL A 1 342 ? 47.969 -75.689  -7.983  1.00 70.47  ? 340 VAL A O   1 
ATOM 2596 C CB  . VAL A 1 342 ? 50.070 -73.232  -7.312  1.00 67.18  ? 340 VAL A CB  1 
ATOM 2597 C CG1 . VAL A 1 342 ? 48.763 -72.642  -7.842  1.00 72.20  ? 340 VAL A CG1 1 
ATOM 2598 C CG2 . VAL A 1 342 ? 50.576 -72.434  -6.115  1.00 62.61  ? 340 VAL A CG2 1 
ATOM 2599 N N   . ILE A 1 343 ? 49.970 -75.820  -9.112  1.00 61.24  ? 341 ILE A N   1 
ATOM 2600 C CA  . ILE A 1 343 ? 49.479 -76.469  -10.311 1.00 58.76  ? 341 ILE A CA  1 
ATOM 2601 C C   . ILE A 1 343 ? 49.016 -77.862  -9.927  1.00 53.25  ? 341 ILE A C   1 
ATOM 2602 O O   . ILE A 1 343 ? 47.829 -78.142  -10.046 1.00 61.07  ? 341 ILE A O   1 
ATOM 2603 C CB  . ILE A 1 343 ? 50.552 -76.478  -11.415 1.00 60.39  ? 341 ILE A CB  1 
ATOM 2604 C CG1 . ILE A 1 343 ? 50.896 -75.047  -11.853 1.00 60.77  ? 341 ILE A CG1 1 
ATOM 2605 C CG2 . ILE A 1 343 ? 50.119 -77.328  -12.608 1.00 64.08  ? 341 ILE A CG2 1 
ATOM 2606 C CD1 . ILE A 1 343 ? 52.278 -74.914  -12.459 1.00 62.68  ? 341 ILE A CD1 1 
ATOM 2607 N N   . GLY A 1 344 ? 49.947 -78.692  -9.441  1.00 49.09  ? 342 GLY A N   1 
ATOM 2608 C CA  . GLY A 1 344 ? 49.624 -80.014  -8.915  1.00 50.13  ? 342 GLY A CA  1 
ATOM 2609 C C   . GLY A 1 344 ? 48.409 -79.990  -7.982  1.00 52.70  ? 342 GLY A C   1 
ATOM 2610 O O   . GLY A 1 344 ? 47.552 -80.870  -8.036  1.00 48.89  ? 342 GLY A O   1 
ATOM 2611 N N   . ASN A 1 345 ? 48.332 -78.959  -7.136  1.00 52.68  ? 343 ASN A N   1 
ATOM 2612 C CA  . ASN A 1 345 ? 47.202 -78.777  -6.242  1.00 56.06  ? 343 ASN A CA  1 
ATOM 2613 C C   . ASN A 1 345 ? 45.922 -78.520  -7.028  1.00 55.28  ? 343 ASN A C   1 
ATOM 2614 O O   . ASN A 1 345 ? 44.874 -79.045  -6.679  1.00 64.32  ? 343 ASN A O   1 
ATOM 2615 C CB  . ASN A 1 345 ? 47.467 -77.669  -5.231  1.00 65.03  ? 343 ASN A CB  1 
ATOM 2616 C CG  . ASN A 1 345 ? 48.557 -78.068  -4.261  1.00 69.17  ? 343 ASN A CG  1 
ATOM 2617 O OD1 . ASN A 1 345 ? 49.393 -78.922  -4.582  1.00 80.38  ? 343 ASN A OD1 1 
ATOM 2618 N ND2 . ASN A 1 345 ? 48.579 -77.461  -3.085  1.00 65.32  ? 343 ASN A ND2 1 
ATOM 2619 N N   . ASP A 1 346 ? 45.994 -77.703  -8.075  1.00 56.57  ? 344 ASP A N   1 
ATOM 2620 C CA  . ASP A 1 346 ? 44.827 -77.468  -8.907  1.00 61.61  ? 344 ASP A CA  1 
ATOM 2621 C C   . ASP A 1 346 ? 44.280 -78.800  -9.434  1.00 58.60  ? 344 ASP A C   1 
ATOM 2622 O O   . ASP A 1 346 ? 43.066 -78.956  -9.540  1.00 53.95  ? 344 ASP A O   1 
ATOM 2623 C CB  . ASP A 1 346 ? 45.119 -76.420  -9.972  1.00 68.85  ? 344 ASP A CB  1 
ATOM 2624 C CG  . ASP A 1 346 ? 43.983 -76.098  -10.936 1.00 77.35  ? 344 ASP A CG  1 
ATOM 2625 O OD1 . ASP A 1 346 ? 43.008 -75.390  -10.540 1.00 64.96  ? 344 ASP A OD1 1 
ATOM 2626 O OD2 . ASP A 1 346 ? 44.081 -76.570  -12.088 1.00 93.02  ? 344 ASP A OD2 1 
ATOM 2627 N N   . HIS A 1 347 ? 45.159 -79.768  -9.742  1.00 67.81  ? 345 HIS A N   1 
ATOM 2628 C CA  . HIS A 1 347 ? 44.731 -81.032  -10.342 1.00 75.42  ? 345 HIS A CA  1 
ATOM 2629 C C   . HIS A 1 347 ? 43.986 -81.829  -9.282  1.00 64.16  ? 345 HIS A C   1 
ATOM 2630 O O   . HIS A 1 347 ? 42.942 -82.396  -9.576  1.00 56.26  ? 345 HIS A O   1 
ATOM 2631 C CB  . HIS A 1 347 ? 45.873 -81.767  -11.077 1.00 85.27  ? 345 HIS A CB  1 
ATOM 2632 C CG  . HIS A 1 347 ? 46.554 -80.888  -12.096 1.00 121.73 ? 345 HIS A CG  1 
ATOM 2633 N ND1 . HIS A 1 347 ? 45.953 -79.720  -12.530 1.00 155.27 ? 345 HIS A ND1 1 
ATOM 2634 C CD2 . HIS A 1 347 ? 47.745 -80.929  -12.732 1.00 132.57 ? 345 HIS A CD2 1 
ATOM 2635 C CE1 . HIS A 1 347 ? 46.743 -79.100  -13.399 1.00 146.16 ? 345 HIS A CE1 1 
ATOM 2636 N NE2 . HIS A 1 347 ? 47.836 -79.822  -13.539 1.00 149.58 ? 345 HIS A NE2 1 
ATOM 2637 N N   . THR A 1 348 ? 44.507 -81.798  -8.050  1.00 66.76  ? 346 THR A N   1 
ATOM 2638 C CA  . THR A 1 348 ? 43.856 -82.406  -6.903  1.00 57.38  ? 346 THR A CA  1 
ATOM 2639 C C   . THR A 1 348 ? 42.491 -81.765  -6.699  1.00 53.64  ? 346 THR A C   1 
ATOM 2640 O O   . THR A 1 348 ? 41.495 -82.474  -6.616  1.00 55.37  ? 346 THR A O   1 
ATOM 2641 C CB  . THR A 1 348 ? 44.715 -82.215  -5.658  1.00 55.00  ? 346 THR A CB  1 
ATOM 2642 O OG1 . THR A 1 348 ? 45.982 -82.770  -5.976  1.00 50.78  ? 346 THR A OG1 1 
ATOM 2643 C CG2 . THR A 1 348 ? 44.142 -82.938  -4.457  1.00 57.59  ? 346 THR A CG2 1 
ATOM 2644 N N   . ILE A 1 349 ? 42.470 -80.433  -6.587  1.00 47.82  ? 347 ILE A N   1 
ATOM 2645 C CA  . ILE A 1 349 ? 41.234 -79.689  -6.417  1.00 52.05  ? 347 ILE A CA  1 
ATOM 2646 C C   . ILE A 1 349 ? 40.227 -80.093  -7.490  1.00 54.82  ? 347 ILE A C   1 
ATOM 2647 O O   . ILE A 1 349 ? 39.073 -80.389  -7.176  1.00 55.67  ? 347 ILE A O   1 
ATOM 2648 C CB  . ILE A 1 349 ? 41.502 -78.171  -6.434  1.00 56.22  ? 347 ILE A CB  1 
ATOM 2649 C CG1 . ILE A 1 349 ? 42.179 -77.733  -5.137  1.00 60.51  ? 347 ILE A CG1 1 
ATOM 2650 C CG2 . ILE A 1 349 ? 40.222 -77.366  -6.699  1.00 53.63  ? 347 ILE A CG2 1 
ATOM 2651 C CD1 . ILE A 1 349 ? 42.883 -76.391  -5.218  1.00 62.52  ? 347 ILE A CD1 1 
ATOM 2652 N N   . CYS A 1 350 ? 40.662 -80.081  -8.757  1.00 54.88  ? 348 CYS A N   1 
ATOM 2653 C CA  . CYS A 1 350 ? 39.742 -80.293  -9.861  1.00 57.78  ? 348 CYS A CA  1 
ATOM 2654 C C   . CYS A 1 350 ? 39.156 -81.700  -9.754  1.00 55.66  ? 348 CYS A C   1 
ATOM 2655 O O   . CYS A 1 350 ? 37.940 -81.874  -9.734  1.00 58.84  ? 348 CYS A O   1 
ATOM 2656 C CB  . CYS A 1 350 ? 40.384 -79.913  -11.192 1.00 61.80  ? 348 CYS A CB  1 
ATOM 2657 S SG  . CYS A 1 350 ? 40.325 -78.129  -11.508 1.00 73.39  ? 348 CYS A SG  1 
ATOM 2658 N N   . LEU A 1 351 ? 40.030 -82.698  -9.637  1.00 55.71  ? 349 LEU A N   1 
ATOM 2659 C CA  . LEU A 1 351 ? 39.613 -84.073  -9.422  1.00 60.88  ? 349 LEU A CA  1 
ATOM 2660 C C   . LEU A 1 351 ? 38.529 -84.163  -8.355  1.00 60.97  ? 349 LEU A C   1 
ATOM 2661 O O   . LEU A 1 351 ? 37.564 -84.904  -8.519  1.00 60.88  ? 349 LEU A O   1 
ATOM 2662 C CB  . LEU A 1 351 ? 40.819 -84.877  -8.956  1.00 68.25  ? 349 LEU A CB  1 
ATOM 2663 C CG  . LEU A 1 351 ? 41.797 -85.316  -10.036 1.00 68.43  ? 349 LEU A CG  1 
ATOM 2664 C CD1 . LEU A 1 351 ? 43.127 -85.701  -9.373  1.00 68.91  ? 349 LEU A CD1 1 
ATOM 2665 C CD2 . LEU A 1 351 ? 41.130 -86.465  -10.770 1.00 69.50  ? 349 LEU A CD2 1 
ATOM 2666 N N   . ALA A 1 352 ? 38.765 -83.480  -7.230  1.00 58.66  ? 350 ALA A N   1 
ATOM 2667 C CA  . ALA A 1 352 ? 37.916 -83.585  -6.057  1.00 59.19  ? 350 ALA A CA  1 
ATOM 2668 C C   . ALA A 1 352 ? 36.582 -82.921  -6.358  1.00 54.22  ? 350 ALA A C   1 
ATOM 2669 O O   . ALA A 1 352 ? 35.532 -83.425  -5.978  1.00 53.57  ? 350 ALA A O   1 
ATOM 2670 C CB  . ALA A 1 352 ? 38.592 -82.935  -4.866  1.00 60.13  ? 350 ALA A CB  1 
ATOM 2671 N N   . SER A 1 353 ? 36.650 -81.779  -7.037  1.00 50.22  ? 351 SER A N   1 
ATOM 2672 C CA  . SER A 1 353 ? 35.466 -81.018  -7.378  1.00 50.98  ? 351 SER A CA  1 
ATOM 2673 C C   . SER A 1 353 ? 34.551 -81.835  -8.282  1.00 51.86  ? 351 SER A C   1 
ATOM 2674 O O   . SER A 1 353 ? 33.333 -81.755  -8.161  1.00 53.17  ? 351 SER A O   1 
ATOM 2675 C CB  . SER A 1 353 ? 35.864 -79.730  -8.021  1.00 54.87  ? 351 SER A CB  1 
ATOM 2676 O OG  . SER A 1 353 ? 34.767 -79.110  -8.670  1.00 56.88  ? 351 SER A OG  1 
ATOM 2677 N N   . GLU A 1 354 ? 35.154 -82.620  -9.180  1.00 56.03  ? 352 GLU A N   1 
ATOM 2678 C CA  . GLU A 1 354 ? 34.419 -83.427  -10.143 1.00 60.05  ? 352 GLU A CA  1 
ATOM 2679 C C   . GLU A 1 354 ? 33.770 -84.642  -9.476  1.00 67.21  ? 352 GLU A C   1 
ATOM 2680 O O   . GLU A 1 354 ? 32.711 -85.099  -9.910  1.00 64.82  ? 352 GLU A O   1 
ATOM 2681 C CB  . GLU A 1 354 ? 35.408 -83.837  -11.231 1.00 61.90  ? 352 GLU A CB  1 
ATOM 2682 C CG  . GLU A 1 354 ? 34.777 -84.446  -12.486 1.00 61.70  ? 352 GLU A CG  1 
ATOM 2683 C CD  . GLU A 1 354 ? 34.728 -85.960  -12.486 1.00 57.54  ? 352 GLU A CD  1 
ATOM 2684 O OE1 . GLU A 1 354 ? 35.135 -86.590  -11.486 1.00 61.33  ? 352 GLU A OE1 1 
ATOM 2685 O OE2 . GLU A 1 354 ? 34.297 -86.508  -13.508 1.00 52.41  ? 352 GLU A OE2 1 
ATOM 2686 N N   . ALA A 1 355 ? 34.415 -85.157  -8.418  1.00 71.43  ? 353 ALA A N   1 
ATOM 2687 C CA  . ALA A 1 355 ? 34.018 -86.413  -7.796  1.00 76.79  ? 353 ALA A CA  1 
ATOM 2688 C C   . ALA A 1 355 ? 32.696 -86.274  -7.050  1.00 72.71  ? 353 ALA A C   1 
ATOM 2689 O O   . ALA A 1 355 ? 32.143 -87.284  -6.603  1.00 68.31  ? 353 ALA A O   1 
ATOM 2690 C CB  . ALA A 1 355 ? 35.106 -86.913  -6.869  1.00 81.70  ? 353 ALA A CB  1 
ATOM 2691 N N   . GLY A 1 356 ? 32.188 -85.035  -6.942  1.00 64.99  ? 354 GLY A N   1 
ATOM 2692 C CA  . GLY A 1 356 ? 30.884 -84.781  -6.356  1.00 67.59  ? 354 GLY A CA  1 
ATOM 2693 C C   . GLY A 1 356 ? 29.824 -85.720  -6.920  1.00 71.47  ? 354 GLY A C   1 
ATOM 2694 O O   . GLY A 1 356 ? 29.862 -86.074  -8.100  1.00 76.66  ? 354 GLY A O   1 
ATOM 2695 N N   . GLN A 1 357 ? 28.901 -86.144  -6.043  1.00 67.80  ? 355 GLN A N   1 
ATOM 2696 C CA  . GLN A 1 357 ? 27.775 -86.973  -6.439  1.00 61.28  ? 355 GLN A CA  1 
ATOM 2697 C C   . GLN A 1 357 ? 26.496 -86.409  -5.826  1.00 60.76  ? 355 GLN A C   1 
ATOM 2698 O O   . GLN A 1 357 ? 26.383 -86.313  -4.606  1.00 65.81  ? 355 GLN A O   1 
ATOM 2699 C CB  . GLN A 1 357 ? 28.001 -88.433  -6.050  1.00 56.66  ? 355 GLN A CB  1 
ATOM 2700 C CG  . GLN A 1 357 ? 29.111 -89.099  -6.855  1.00 58.42  ? 355 GLN A CG  1 
ATOM 2701 C CD  . GLN A 1 357 ? 29.454 -90.490  -6.383  1.00 62.79  ? 355 GLN A CD  1 
ATOM 2702 O OE1 . GLN A 1 357 ? 29.352 -90.847  -5.205  1.00 55.43  ? 355 GLN A OE1 1 
ATOM 2703 N NE2 . GLN A 1 357 ? 29.865 -91.301  -7.337  1.00 70.78  ? 355 GLN A NE2 1 
ATOM 2704 N N   . LEU A 1 358 ? 25.553 -86.041  -6.706  1.00 58.89  ? 356 LEU A N   1 
ATOM 2705 C CA  . LEU A 1 358 ? 24.206 -85.632  -6.337  1.00 62.51  ? 356 LEU A CA  1 
ATOM 2706 C C   . LEU A 1 358 ? 24.279 -84.476  -5.331  1.00 61.91  ? 356 LEU A C   1 
ATOM 2707 O O   . LEU A 1 358 ? 24.854 -83.443  -5.680  1.00 59.70  ? 356 LEU A O   1 
ATOM 2708 C CB  . LEU A 1 358 ? 23.421 -86.866  -5.881  1.00 67.37  ? 356 LEU A CB  1 
ATOM 2709 C CG  . LEU A 1 358 ? 23.226 -87.969  -6.938  1.00 60.63  ? 356 LEU A CG  1 
ATOM 2710 C CD1 . LEU A 1 358 ? 22.740 -89.276  -6.356  1.00 58.27  ? 356 LEU A CD1 1 
ATOM 2711 C CD2 . LEU A 1 358 ? 22.269 -87.530  -8.022  1.00 58.52  ? 356 LEU A CD2 1 
ATOM 2712 N N   . GLU A 1 359 ? 23.735 -84.621  -4.104  1.00 59.21  ? 357 GLU A N   1 
ATOM 2713 C CA  . GLU A 1 359 ? 23.428 -83.440  -3.304  1.00 62.37  ? 357 GLU A CA  1 
ATOM 2714 C C   . GLU A 1 359 ? 24.646 -82.955  -2.518  1.00 65.50  ? 357 GLU A C   1 
ATOM 2715 O O   . GLU A 1 359 ? 24.573 -81.877  -1.928  1.00 71.53  ? 357 GLU A O   1 
ATOM 2716 C CB  . GLU A 1 359 ? 22.338 -83.509  -2.234  1.00 60.20  ? 357 GLU A CB  1 
ATOM 2717 C CG  . GLU A 1 359 ? 21.198 -84.492  -2.463  1.00 61.84  ? 357 GLU A CG  1 
ATOM 2718 C CD  . GLU A 1 359 ? 20.704 -84.706  -3.872  1.00 68.70  ? 357 GLU A CD  1 
ATOM 2719 O OE1 . GLU A 1 359 ? 20.575 -83.670  -4.560  1.00 77.03  ? 357 GLU A OE1 1 
ATOM 2720 O OE2 . GLU A 1 359 ? 20.439 -85.880  -4.253  1.00 77.47  ? 357 GLU A OE2 1 
ATOM 2721 N N   . LEU A 1 360 ? 25.749 -83.723  -2.506  1.00 68.63  ? 358 LEU A N   1 
ATOM 2722 C CA  . LEU A 1 360 ? 26.918 -83.337  -1.727  1.00 77.98  ? 358 LEU A CA  1 
ATOM 2723 C C   . LEU A 1 360 ? 28.221 -83.828  -2.355  1.00 81.29  ? 358 LEU A C   1 
ATOM 2724 O O   . LEU A 1 360 ? 28.304 -84.952  -2.854  1.00 77.77  ? 358 LEU A O   1 
ATOM 2725 C CB  . LEU A 1 360 ? 26.812 -83.856  -0.293  1.00 82.44  ? 358 LEU A CB  1 
ATOM 2726 C CG  . LEU A 1 360 ? 27.972 -83.479  0.632   1.00 77.37  ? 358 LEU A CG  1 
ATOM 2727 C CD1 . LEU A 1 360 ? 28.014 -81.976  0.842   1.00 82.14  ? 358 LEU A CD1 1 
ATOM 2728 C CD2 . LEU A 1 360 ? 27.890 -84.199  1.950   1.00 81.28  ? 358 LEU A CD2 1 
ATOM 2729 N N   . ASN A 1 361 ? 29.242 -82.962  -2.248  1.00 79.17  ? 359 ASN A N   1 
ATOM 2730 C CA  . ASN A 1 361 ? 30.615 -83.286  -2.575  1.00 69.85  ? 359 ASN A CA  1 
ATOM 2731 C C   . ASN A 1 361 ? 31.356 -83.613  -1.286  1.00 67.26  ? 359 ASN A C   1 
ATOM 2732 O O   . ASN A 1 361 ? 31.592 -82.729  -0.472  1.00 70.43  ? 359 ASN A O   1 
ATOM 2733 C CB  . ASN A 1 361 ? 31.283 -82.120  -3.289  1.00 69.87  ? 359 ASN A CB  1 
ATOM 2734 C CG  . ASN A 1 361 ? 32.570 -82.527  -3.964  1.00 71.07  ? 359 ASN A CG  1 
ATOM 2735 O OD1 . ASN A 1 361 ? 33.393 -83.212  -3.356  1.00 66.61  ? 359 ASN A OD1 1 
ATOM 2736 N ND2 . ASN A 1 361 ? 32.759 -82.142  -5.220  1.00 79.32  ? 359 ASN A ND2 1 
ATOM 2737 N N   . VAL A 1 362 ? 31.757 -84.879  -1.132  1.00 69.76  ? 360 VAL A N   1 
ATOM 2738 C CA  . VAL A 1 362 ? 32.318 -85.385  0.113   1.00 71.70  ? 360 VAL A CA  1 
ATOM 2739 C C   . VAL A 1 362 ? 33.837 -85.238  0.131   1.00 67.22  ? 360 VAL A C   1 
ATOM 2740 O O   . VAL A 1 362 ? 34.484 -85.611  1.113   1.00 63.59  ? 360 VAL A O   1 
ATOM 2741 C CB  . VAL A 1 362 ? 31.944 -86.864  0.345   1.00 74.60  ? 360 VAL A CB  1 
ATOM 2742 C CG1 . VAL A 1 362 ? 30.435 -87.072  0.409   1.00 70.67  ? 360 VAL A CG1 1 
ATOM 2743 C CG2 . VAL A 1 362 ? 32.586 -87.786  -0.688  1.00 71.04  ? 360 VAL A CG2 1 
ATOM 2744 N N   . MET A 1 363 ? 34.395 -84.739  -0.974  1.00 65.79  ? 361 MET A N   1 
ATOM 2745 C CA  . MET A 1 363 ? 35.834 -84.624  -1.137  1.00 64.02  ? 361 MET A CA  1 
ATOM 2746 C C   . MET A 1 363 ? 36.274 -83.202  -0.796  1.00 60.24  ? 361 MET A C   1 
ATOM 2747 O O   . MET A 1 363 ? 37.413 -82.827  -1.060  1.00 51.77  ? 361 MET A O   1 
ATOM 2748 C CB  . MET A 1 363 ? 36.231 -85.001  -2.573  1.00 61.76  ? 361 MET A CB  1 
ATOM 2749 C CG  . MET A 1 363 ? 35.620 -86.310  -3.042  1.00 62.28  ? 361 MET A CG  1 
ATOM 2750 S SD  . MET A 1 363 ? 36.205 -87.730  -2.096  1.00 62.99  ? 361 MET A SD  1 
ATOM 2751 C CE  . MET A 1 363 ? 35.165 -89.059  -2.710  1.00 58.92  ? 361 MET A CE  1 
ATOM 2752 N N   . GLU A 1 364 ? 35.372 -82.417  -0.191  1.00 64.22  ? 362 GLU A N   1 
ATOM 2753 C CA  . GLU A 1 364 ? 35.641 -81.004  0.015   1.00 66.54  ? 362 GLU A CA  1 
ATOM 2754 C C   . GLU A 1 364 ? 36.924 -80.828  0.824   1.00 60.37  ? 362 GLU A C   1 
ATOM 2755 O O   . GLU A 1 364 ? 37.658 -79.887  0.567   1.00 58.02  ? 362 GLU A O   1 
ATOM 2756 C CB  . GLU A 1 364 ? 34.455 -80.261  0.630   1.00 70.75  ? 362 GLU A CB  1 
ATOM 2757 C CG  . GLU A 1 364 ? 33.467 -79.742  -0.415  1.00 79.37  ? 362 GLU A CG  1 
ATOM 2758 C CD  . GLU A 1 364 ? 32.572 -78.583  0.010   1.00 88.61  ? 362 GLU A CD  1 
ATOM 2759 O OE1 . GLU A 1 364 ? 32.867 -77.880  1.012   1.00 90.28  ? 362 GLU A OE1 1 
ATOM 2760 O OE2 . GLU A 1 364 ? 31.548 -78.387  -0.685  1.00 85.10  ? 362 GLU A OE2 1 
ATOM 2761 N N   . PRO A 1 365 ? 37.259 -81.706  1.799   1.00 56.03  ? 363 PRO A N   1 
ATOM 2762 C CA  . PRO A 1 365 ? 38.464 -81.516  2.615   1.00 56.64  ? 363 PRO A CA  1 
ATOM 2763 C C   . PRO A 1 365 ? 39.783 -81.401  1.849   1.00 53.66  ? 363 PRO A C   1 
ATOM 2764 O O   . PRO A 1 365 ? 40.414 -80.354  1.879   1.00 49.51  ? 363 PRO A O   1 
ATOM 2765 C CB  . PRO A 1 365 ? 38.440 -82.729  3.558   1.00 60.48  ? 363 PRO A CB  1 
ATOM 2766 C CG  . PRO A 1 365 ? 36.975 -83.107  3.615   1.00 62.35  ? 363 PRO A CG  1 
ATOM 2767 C CD  . PRO A 1 365 ? 36.481 -82.886  2.206   1.00 58.85  ? 363 PRO A CD  1 
ATOM 2768 N N   . VAL A 1 366 ? 40.201 -82.455  1.144   1.00 51.12  ? 364 VAL A N   1 
ATOM 2769 C CA  . VAL A 1 366 ? 41.455 -82.406  0.406   1.00 49.03  ? 364 VAL A CA  1 
ATOM 2770 C C   . VAL A 1 366 ? 41.419 -81.190  -0.518  1.00 47.55  ? 364 VAL A C   1 
ATOM 2771 O O   . VAL A 1 366 ? 42.418 -80.491  -0.687  1.00 45.40  ? 364 VAL A O   1 
ATOM 2772 C CB  . VAL A 1 366 ? 41.765 -83.712  -0.358  1.00 47.14  ? 364 VAL A CB  1 
ATOM 2773 C CG1 . VAL A 1 366 ? 40.771 -83.984  -1.474  1.00 47.27  ? 364 VAL A CG1 1 
ATOM 2774 C CG2 . VAL A 1 366 ? 43.188 -83.744  -0.904  1.00 47.09  ? 364 VAL A CG2 1 
ATOM 2775 N N   . LEU A 1 367 ? 40.239 -80.916  -1.079  1.00 50.52  ? 365 LEU A N   1 
ATOM 2776 C CA  . LEU A 1 367 ? 40.045 -79.756  -1.932  1.00 52.64  ? 365 LEU A CA  1 
ATOM 2777 C C   . LEU A 1 367 ? 40.512 -78.498  -1.203  1.00 51.73  ? 365 LEU A C   1 
ATOM 2778 O O   . LEU A 1 367 ? 41.388 -77.784  -1.686  1.00 47.11  ? 365 LEU A O   1 
ATOM 2779 C CB  . LEU A 1 367 ? 38.577 -79.661  -2.350  1.00 56.90  ? 365 LEU A CB  1 
ATOM 2780 C CG  . LEU A 1 367 ? 38.294 -78.715  -3.527  1.00 63.23  ? 365 LEU A CG  1 
ATOM 2781 C CD1 . LEU A 1 367 ? 36.997 -79.025  -4.251  1.00 63.60  ? 365 LEU A CD1 1 
ATOM 2782 C CD2 . LEU A 1 367 ? 38.288 -77.257  -3.095  1.00 60.00  ? 365 LEU A CD2 1 
ATOM 2783 N N   . VAL A 1 368 ? 39.917 -78.270  -0.024  1.00 56.93  ? 366 VAL A N   1 
ATOM 2784 C CA  . VAL A 1 368 ? 40.117 -77.053  0.747   1.00 55.34  ? 366 VAL A CA  1 
ATOM 2785 C C   . VAL A 1 368 ? 41.555 -77.020  1.264   1.00 54.34  ? 366 VAL A C   1 
ATOM 2786 O O   . VAL A 1 368 ? 42.184 -75.964  1.329   1.00 52.84  ? 366 VAL A O   1 
ATOM 2787 C CB  . VAL A 1 368 ? 39.110 -76.925  1.907   1.00 50.17  ? 366 VAL A CB  1 
ATOM 2788 C CG1 . VAL A 1 368 ? 39.338 -75.647  2.692   1.00 51.90  ? 366 VAL A CG1 1 
ATOM 2789 C CG2 . VAL A 1 368 ? 37.665 -76.958  1.438   1.00 51.90  ? 366 VAL A CG2 1 
ATOM 2790 N N   . PHE A 1 369 ? 42.073 -78.192  1.630   1.00 49.63  ? 367 PHE A N   1 
ATOM 2791 C CA  . PHE A 1 369 ? 43.440 -78.292  2.094   1.00 51.77  ? 367 PHE A CA  1 
ATOM 2792 C C   . PHE A 1 369 ? 44.362 -77.715  1.033   1.00 50.82  ? 367 PHE A C   1 
ATOM 2793 O O   . PHE A 1 369 ? 45.169 -76.838  1.321   1.00 54.51  ? 367 PHE A O   1 
ATOM 2794 C CB  . PHE A 1 369 ? 43.810 -79.741  2.411   1.00 58.01  ? 367 PHE A CB  1 
ATOM 2795 C CG  . PHE A 1 369 ? 45.272 -79.905  2.792   1.00 63.94  ? 367 PHE A CG  1 
ATOM 2796 C CD1 . PHE A 1 369 ? 45.878 -79.028  3.687   1.00 64.23  ? 367 PHE A CD1 1 
ATOM 2797 C CD2 . PHE A 1 369 ? 46.047 -80.899  2.206   1.00 69.48  ? 367 PHE A CD2 1 
ATOM 2798 C CE1 . PHE A 1 369 ? 47.209 -79.178  4.020   1.00 70.33  ? 367 PHE A CE1 1 
ATOM 2799 C CE2 . PHE A 1 369 ? 47.382 -81.038  2.539   1.00 72.73  ? 367 PHE A CE2 1 
ATOM 2800 C CZ  . PHE A 1 369 ? 47.956 -80.188  3.451   1.00 72.18  ? 367 PHE A CZ  1 
ATOM 2801 N N   . ASN A 1 370 ? 44.219 -78.202  -0.200  1.00 49.81  ? 368 ASN A N   1 
ATOM 2802 C CA  . ASN A 1 370 ? 45.066 -77.738  -1.279  1.00 51.76  ? 368 ASN A CA  1 
ATOM 2803 C C   . ASN A 1 370 ? 44.761 -76.277  -1.600  1.00 54.30  ? 368 ASN A C   1 
ATOM 2804 O O   . ASN A 1 370 ? 45.684 -75.501  -1.840  1.00 60.66  ? 368 ASN A O   1 
ATOM 2805 C CB  . ASN A 1 370 ? 44.941 -78.634  -2.498  1.00 55.94  ? 368 ASN A CB  1 
ATOM 2806 C CG  . ASN A 1 370 ? 45.628 -79.954  -2.262  1.00 58.52  ? 368 ASN A CG  1 
ATOM 2807 O OD1 . ASN A 1 370 ? 46.794 -80.129  -2.638  1.00 66.95  ? 368 ASN A OD1 1 
ATOM 2808 N ND2 . ASN A 1 370 ? 44.943 -80.864  -1.590  1.00 58.74  ? 368 ASN A ND2 1 
ATOM 2809 N N   . LEU A 1 371 ? 43.474 -75.902  -1.599  1.00 50.78  ? 369 LEU A N   1 
ATOM 2810 C CA  . LEU A 1 371 ? 43.099 -74.542  -1.945  1.00 48.76  ? 369 LEU A CA  1 
ATOM 2811 C C   . LEU A 1 371 ? 43.780 -73.572  -0.982  1.00 54.80  ? 369 LEU A C   1 
ATOM 2812 O O   . LEU A 1 371 ? 44.478 -72.654  -1.414  1.00 57.74  ? 369 LEU A O   1 
ATOM 2813 C CB  . LEU A 1 371 ? 41.585 -74.357  -1.942  1.00 46.53  ? 369 LEU A CB  1 
ATOM 2814 C CG  . LEU A 1 371 ? 41.080 -72.947  -2.268  1.00 48.99  ? 369 LEU A CG  1 
ATOM 2815 C CD1 . LEU A 1 371 ? 41.706 -72.326  -3.482  1.00 48.61  ? 369 LEU A CD1 1 
ATOM 2816 C CD2 . LEU A 1 371 ? 39.591 -72.992  -2.501  1.00 55.55  ? 369 LEU A CD2 1 
ATOM 2817 N N   . LEU A 1 372 ? 43.582 -73.790  0.324   1.00 56.25  ? 370 LEU A N   1 
ATOM 2818 C CA  . LEU A 1 372 ? 44.086 -72.876  1.333   1.00 53.79  ? 370 LEU A CA  1 
ATOM 2819 C C   . LEU A 1 372 ? 45.602 -72.870  1.253   1.00 53.11  ? 370 LEU A C   1 
ATOM 2820 O O   . LEU A 1 372 ? 46.205 -71.802  1.247   1.00 60.54  ? 370 LEU A O   1 
ATOM 2821 C CB  . LEU A 1 372 ? 43.546 -73.235  2.719   1.00 52.13  ? 370 LEU A CB  1 
ATOM 2822 C CG  . LEU A 1 372 ? 42.032 -73.013  2.884   1.00 57.11  ? 370 LEU A CG  1 
ATOM 2823 C CD1 . LEU A 1 372 ? 41.505 -73.516  4.188   1.00 59.49  ? 370 LEU A CD1 1 
ATOM 2824 C CD2 . LEU A 1 372 ? 41.556 -71.569  2.749   1.00 58.52  ? 370 LEU A CD2 1 
ATOM 2825 N N   . GLN A 1 373 ? 46.193 -74.060  1.113   1.00 52.03  ? 371 GLN A N   1 
ATOM 2826 C CA  . GLN A 1 373 ? 47.639 -74.183  1.011   1.00 50.83  ? 371 GLN A CA  1 
ATOM 2827 C C   . GLN A 1 373 ? 48.172 -73.332  -0.128  1.00 54.03  ? 371 GLN A C   1 
ATOM 2828 O O   . GLN A 1 373 ? 49.130 -72.587  0.062   1.00 49.66  ? 371 GLN A O   1 
ATOM 2829 C CB  . GLN A 1 373 ? 48.129 -75.577  0.638   1.00 49.31  ? 371 GLN A CB  1 
ATOM 2830 C CG  . GLN A 1 373 ? 49.623 -75.602  0.355   1.00 48.69  ? 371 GLN A CG  1 
ATOM 2831 C CD  . GLN A 1 373 ? 50.155 -77.005  0.213   1.00 52.01  ? 371 GLN A CD  1 
ATOM 2832 O OE1 . GLN A 1 373 ? 50.689 -77.372  -0.833  1.00 67.28  ? 371 GLN A OE1 1 
ATOM 2833 N NE2 . GLN A 1 373 ? 49.993 -77.818  1.243   1.00 54.92  ? 371 GLN A NE2 1 
ATOM 2834 N N   . SER A 1 374 ? 47.573 -73.515  -1.315  1.00 59.26  ? 372 SER A N   1 
ATOM 2835 C CA  . SER A 1 374 ? 47.981 -72.788  -2.503  1.00 60.35  ? 372 SER A CA  1 
ATOM 2836 C C   . SER A 1 374 ? 48.022 -71.287  -2.201  1.00 60.21  ? 372 SER A C   1 
ATOM 2837 O O   . SER A 1 374 ? 49.047 -70.652  -2.419  1.00 66.20  ? 372 SER A O   1 
ATOM 2838 C CB  . SER A 1 374 ? 47.095 -73.123  -3.691  1.00 68.60  ? 372 SER A CB  1 
ATOM 2839 O OG  . SER A 1 374 ? 47.451 -74.352  -4.328  1.00 72.71  ? 372 SER A OG  1 
ATOM 2840 N N   . ILE A 1 375 ? 46.944 -70.736  -1.631  1.00 56.29  ? 373 ILE A N   1 
ATOM 2841 C CA  . ILE A 1 375 ? 46.843 -69.298  -1.408  1.00 59.52  ? 373 ILE A CA  1 
ATOM 2842 C C   . ILE A 1 375 ? 47.921 -68.836  -0.429  1.00 56.62  ? 373 ILE A C   1 
ATOM 2843 O O   . ILE A 1 375 ? 48.524 -67.784  -0.605  1.00 50.64  ? 373 ILE A O   1 
ATOM 2844 C CB  . ILE A 1 375 ? 45.449 -68.898  -0.881  1.00 66.39  ? 373 ILE A CB  1 
ATOM 2845 C CG1 . ILE A 1 375 ? 44.304 -69.383  -1.803  1.00 61.83  ? 373 ILE A CG1 1 
ATOM 2846 C CG2 . ILE A 1 375 ? 45.391 -67.382  -0.633  1.00 66.96  ? 373 ILE A CG2 1 
ATOM 2847 C CD1 . ILE A 1 375 ? 42.953 -69.462  -1.116  1.00 56.92  ? 373 ILE A CD1 1 
ATOM 2848 N N   . SER A 1 376 ? 48.106 -69.607  0.643   1.00 58.26  ? 374 SER A N   1 
ATOM 2849 C CA  . SER A 1 376 ? 49.093 -69.293  1.656   1.00 62.75  ? 374 SER A CA  1 
ATOM 2850 C C   . SER A 1 376 ? 50.484 -69.279  1.037   1.00 61.69  ? 374 SER A C   1 
ATOM 2851 O O   . SER A 1 376 ? 51.109 -68.228  0.980   1.00 63.97  ? 374 SER A O   1 
ATOM 2852 C CB  . SER A 1 376 ? 49.023 -70.280  2.783   1.00 74.18  ? 374 SER A CB  1 
ATOM 2853 O OG  . SER A 1 376 ? 47.683 -70.433  3.224   1.00 87.10  ? 374 SER A OG  1 
ATOM 2854 N N   . ILE A 1 377 ? 50.927 -70.434  0.517   1.00 52.51  ? 375 ILE A N   1 
ATOM 2855 C CA  . ILE A 1 377 ? 52.281 -70.558  0.026   1.00 47.71  ? 375 ILE A CA  1 
ATOM 2856 C C   . ILE A 1 377 ? 52.561 -69.464  -0.997  1.00 50.05  ? 375 ILE A C   1 
ATOM 2857 O O   . ILE A 1 377 ? 53.677 -68.958  -1.018  1.00 54.45  ? 375 ILE A O   1 
ATOM 2858 C CB  . ILE A 1 377 ? 52.582 -71.943  -0.555  1.00 55.44  ? 375 ILE A CB  1 
ATOM 2859 C CG1 . ILE A 1 377 ? 51.798 -72.255  -1.798  1.00 63.62  ? 375 ILE A CG1 1 
ATOM 2860 C CG2 . ILE A 1 377 ? 52.407 -73.051  0.473   1.00 58.54  ? 375 ILE A CG2 1 
ATOM 2861 C CD1 . ILE A 1 377 ? 52.168 -73.617  -2.367  1.00 69.88  ? 375 ILE A CD1 1 
ATOM 2862 N N   . MET A 1 378 ? 51.564 -69.070  -1.803  1.00 48.17  ? 376 MET A N   1 
ATOM 2863 C CA  . MET A 1 378 ? 51.759 -68.001  -2.776  1.00 54.61  ? 376 MET A CA  1 
ATOM 2864 C C   . MET A 1 378 ? 52.037 -66.677  -2.062  1.00 55.67  ? 376 MET A C   1 
ATOM 2865 O O   . MET A 1 378 ? 53.016 -65.982  -2.348  1.00 59.69  ? 376 MET A O   1 
ATOM 2866 C CB  . MET A 1 378 ? 50.548 -67.808  -3.700  1.00 58.24  ? 376 MET A CB  1 
ATOM 2867 C CG  . MET A 1 378 ? 50.420 -68.830  -4.828  1.00 63.29  ? 376 MET A CG  1 
ATOM 2868 S SD  . MET A 1 378 ? 48.871 -68.739  -5.756  1.00 60.01  ? 376 MET A SD  1 
ATOM 2869 C CE  . MET A 1 378 ? 49.094 -67.169  -6.607  1.00 62.34  ? 376 MET A CE  1 
ATOM 2870 N N   . ASN A 1 379 ? 51.148 -66.329  -1.133  1.00 56.06  ? 377 ASN A N   1 
ATOM 2871 C CA  . ASN A 1 379 ? 51.246 -65.080  -0.397  1.00 61.98  ? 377 ASN A CA  1 
ATOM 2872 C C   . ASN A 1 379 ? 52.622 -64.961  0.263   1.00 63.49  ? 377 ASN A C   1 
ATOM 2873 O O   . ASN A 1 379 ? 53.188 -63.869  0.327   1.00 64.62  ? 377 ASN A O   1 
ATOM 2874 C CB  . ASN A 1 379 ? 50.111 -64.973  0.618   1.00 60.55  ? 377 ASN A CB  1 
ATOM 2875 C CG  . ASN A 1 379 ? 50.236 -63.750  1.492   1.00 51.75  ? 377 ASN A CG  1 
ATOM 2876 O OD1 . ASN A 1 379 ? 50.613 -63.890  2.654   1.00 51.88  ? 377 ASN A OD1 1 
ATOM 2877 N ND2 . ASN A 1 379 ? 49.983 -62.568  0.950   1.00 48.88  ? 377 ASN A ND2 1 
ATOM 2878 N N   . ASN A 1 380 ? 53.133 -66.091  0.758   1.00 57.31  ? 378 ASN A N   1 
ATOM 2879 C CA  . ASN A 1 380 ? 54.402 -66.121  1.451   1.00 57.61  ? 378 ASN A CA  1 
ATOM 2880 C C   . ASN A 1 380 ? 55.534 -66.007  0.447   1.00 61.52  ? 378 ASN A C   1 
ATOM 2881 O O   . ASN A 1 380 ? 56.421 -65.169  0.603   1.00 71.09  ? 378 ASN A O   1 
ATOM 2882 C CB  . ASN A 1 380 ? 54.541 -67.393  2.269   1.00 59.64  ? 378 ASN A CB  1 
ATOM 2883 C CG  . ASN A 1 380 ? 53.602 -67.415  3.451   1.00 56.06  ? 378 ASN A CG  1 
ATOM 2884 O OD1 . ASN A 1 380 ? 53.163 -66.360  3.947   1.00 49.63  ? 378 ASN A OD1 1 
ATOM 2885 N ND2 . ASN A 1 380 ? 53.326 -68.622  3.929   1.00 52.02  ? 378 ASN A ND2 1 
ATOM 2886 N N   . GLY A 1 381 ? 55.500 -66.862  -0.577  1.00 59.27  ? 379 GLY A N   1 
ATOM 2887 C CA  . GLY A 1 381 ? 56.492 -66.785  -1.636  1.00 64.90  ? 379 GLY A CA  1 
ATOM 2888 C C   . GLY A 1 381 ? 56.630 -65.367  -2.198  1.00 63.97  ? 379 GLY A C   1 
ATOM 2889 O O   . GLY A 1 381 ? 57.741 -64.895  -2.432  1.00 63.49  ? 379 GLY A O   1 
ATOM 2890 N N   . PHE A 1 382 ? 55.494 -64.696  -2.415  1.00 58.08  ? 380 PHE A N   1 
ATOM 2891 C CA  . PHE A 1 382 ? 55.501 -63.393  -3.049  1.00 59.06  ? 380 PHE A CA  1 
ATOM 2892 C C   . PHE A 1 382 ? 56.090 -62.343  -2.120  1.00 55.60  ? 380 PHE A C   1 
ATOM 2893 O O   . PHE A 1 382 ? 56.818 -61.464  -2.571  1.00 58.48  ? 380 PHE A O   1 
ATOM 2894 C CB  . PHE A 1 382 ? 54.086 -62.974  -3.448  1.00 66.77  ? 380 PHE A CB  1 
ATOM 2895 C CG  . PHE A 1 382 ? 53.469 -63.742  -4.609  1.00 63.96  ? 380 PHE A CG  1 
ATOM 2896 C CD1 . PHE A 1 382 ? 54.258 -64.460  -5.506  1.00 58.79  ? 380 PHE A CD1 1 
ATOM 2897 C CD2 . PHE A 1 382 ? 52.094 -63.712  -4.807  1.00 63.17  ? 380 PHE A CD2 1 
ATOM 2898 C CE1 . PHE A 1 382 ? 53.679 -65.148  -6.553  1.00 58.34  ? 380 PHE A CE1 1 
ATOM 2899 C CE2 . PHE A 1 382 ? 51.521 -64.401  -5.858  1.00 66.31  ? 380 PHE A CE2 1 
ATOM 2900 C CZ  . PHE A 1 382 ? 52.315 -65.118  -6.726  1.00 64.01  ? 380 PHE A CZ  1 
ATOM 2901 N N   . ARG A 1 383 ? 55.742 -62.434  -0.835  1.00 59.93  ? 381 ARG A N   1 
ATOM 2902 C CA  . ARG A 1 383 ? 56.164 -61.440  0.141   1.00 67.29  ? 381 ARG A CA  1 
ATOM 2903 C C   . ARG A 1 383 ? 57.695 -61.443  0.168   1.00 66.86  ? 381 ARG A C   1 
ATOM 2904 O O   . ARG A 1 383 ? 58.337 -60.407  -0.019  1.00 63.94  ? 381 ARG A O   1 
ATOM 2905 C CB  . ARG A 1 383 ? 55.511 -61.714  1.509   1.00 74.03  ? 381 ARG A CB  1 
ATOM 2906 C CG  . ARG A 1 383 ? 54.809 -60.545  2.205   1.00 81.08  ? 381 ARG A CG  1 
ATOM 2907 C CD  . ARG A 1 383 ? 54.856 -60.612  3.759   1.00 91.39  ? 381 ARG A CD  1 
ATOM 2908 N NE  . ARG A 1 383 ? 54.610 -61.957  4.307   1.00 105.37 ? 381 ARG A NE  1 
ATOM 2909 C CZ  . ARG A 1 383 ? 55.483 -62.745  4.956   1.00 102.74 ? 381 ARG A CZ  1 
ATOM 2910 N NH1 . ARG A 1 383 ? 56.634 -62.245  5.369   1.00 103.29 ? 381 ARG A NH1 1 
ATOM 2911 N NH2 . ARG A 1 383 ? 55.198 -64.020  5.189   1.00 93.10  ? 381 ARG A NH2 1 
ATOM 2912 N N   . VAL A 1 384 ? 58.267 -62.643  0.309   1.00 66.22  ? 382 VAL A N   1 
ATOM 2913 C CA  . VAL A 1 384 ? 59.695 -62.822  0.490   1.00 63.44  ? 382 VAL A CA  1 
ATOM 2914 C C   . VAL A 1 384 ? 60.425 -62.501  -0.814  1.00 63.02  ? 382 VAL A C   1 
ATOM 2915 O O   . VAL A 1 384 ? 61.537 -61.986  -0.805  1.00 63.97  ? 382 VAL A O   1 
ATOM 2916 C CB  . VAL A 1 384 ? 59.816 -64.282  0.971   1.00 70.00  ? 382 VAL A CB  1 
ATOM 2917 C CG1 . VAL A 1 384 ? 61.240 -64.745  1.137   1.00 78.55  ? 382 VAL A CG1 1 
ATOM 2918 C CG2 . VAL A 1 384 ? 59.075 -64.513  2.284   1.00 79.11  ? 382 VAL A CG2 1 
ATOM 2919 N N   . PHE A 1 385 ? 59.777 -62.799  -1.940  1.00 69.08  ? 383 PHE A N   1 
ATOM 2920 C CA  . PHE A 1 385 ? 60.370 -62.614  -3.255  1.00 69.42  ? 383 PHE A CA  1 
ATOM 2921 C C   . PHE A 1 385 ? 60.359 -61.121  -3.586  1.00 63.79  ? 383 PHE A C   1 
ATOM 2922 O O   . PHE A 1 385 ? 61.295 -60.608  -4.184  1.00 64.05  ? 383 PHE A O   1 
ATOM 2923 C CB  . PHE A 1 385 ? 59.612 -63.518  -4.244  1.00 69.95  ? 383 PHE A CB  1 
ATOM 2924 C CG  . PHE A 1 385 ? 59.885 -63.304  -5.728  1.00 66.99  ? 383 PHE A CG  1 
ATOM 2925 C CD1 . PHE A 1 385 ? 61.038 -63.803  -6.318  1.00 71.70  ? 383 PHE A CD1 1 
ATOM 2926 C CD2 . PHE A 1 385 ? 58.967 -62.646  -6.538  1.00 67.88  ? 383 PHE A CD2 1 
ATOM 2927 C CE1 . PHE A 1 385 ? 61.294 -63.610  -7.667  1.00 74.01  ? 383 PHE A CE1 1 
ATOM 2928 C CE2 . PHE A 1 385 ? 59.225 -62.451  -7.885  1.00 74.08  ? 383 PHE A CE2 1 
ATOM 2929 C CZ  . PHE A 1 385 ? 60.391 -62.926  -8.444  1.00 75.38  ? 383 PHE A CZ  1 
ATOM 2930 N N   . THR A 1 386 ? 59.287 -60.429  -3.199  1.00 59.67  ? 384 THR A N   1 
ATOM 2931 C CA  . THR A 1 386 ? 59.224 -58.999  -3.414  1.00 63.80  ? 384 THR A CA  1 
ATOM 2932 C C   . THR A 1 386 ? 60.404 -58.369  -2.673  1.00 68.34  ? 384 THR A C   1 
ATOM 2933 O O   . THR A 1 386 ? 61.218 -57.683  -3.294  1.00 74.99  ? 384 THR A O   1 
ATOM 2934 C CB  . THR A 1 386 ? 57.874 -58.419  -2.976  1.00 70.91  ? 384 THR A CB  1 
ATOM 2935 O OG1 . THR A 1 386 ? 56.801 -59.135  -3.582  1.00 65.72  ? 384 THR A OG1 1 
ATOM 2936 C CG2 . THR A 1 386 ? 57.712 -56.962  -3.376  1.00 70.65  ? 384 THR A CG2 1 
ATOM 2937 N N   . GLU A 1 387 ? 60.531 -58.660  -1.368  1.00 68.76  ? 385 GLU A N   1 
ATOM 2938 C CA  . GLU A 1 387 ? 61.478 -57.954  -0.512  1.00 69.19  ? 385 GLU A CA  1 
ATOM 2939 C C   . GLU A 1 387 ? 62.919 -58.403  -0.749  1.00 65.96  ? 385 GLU A C   1 
ATOM 2940 O O   . GLU A 1 387 ? 63.809 -57.569  -0.788  1.00 66.45  ? 385 GLU A O   1 
ATOM 2941 C CB  . GLU A 1 387 ? 61.228 -58.125  0.986   1.00 69.17  ? 385 GLU A CB  1 
ATOM 2942 C CG  . GLU A 1 387 ? 59.891 -57.566  1.469   1.00 74.41  ? 385 GLU A CG  1 
ATOM 2943 C CD  . GLU A 1 387 ? 59.554 -56.209  0.894   1.00 76.29  ? 385 GLU A CD  1 
ATOM 2944 O OE1 . GLU A 1 387 ? 60.446 -55.345  0.943   1.00 80.45  ? 385 GLU A OE1 1 
ATOM 2945 O OE2 . GLU A 1 387 ? 58.439 -56.027  0.373   1.00 77.67  ? 385 GLU A OE2 1 
ATOM 2946 N N   . TYR A 1 388 ? 63.160 -59.709  -0.878  1.00 67.03  ? 386 TYR A N   1 
ATOM 2947 C CA  . TYR A 1 388 ? 64.518 -60.211  -0.836  1.00 68.10  ? 386 TYR A CA  1 
ATOM 2948 C C   . TYR A 1 388 ? 65.089 -60.436  -2.231  1.00 74.95  ? 386 TYR A C   1 
ATOM 2949 O O   . TYR A 1 388 ? 66.215 -60.906  -2.343  1.00 85.81  ? 386 TYR A O   1 
ATOM 2950 C CB  . TYR A 1 388 ? 64.557 -61.506  -0.028  1.00 68.67  ? 386 TYR A CB  1 
ATOM 2951 C CG  . TYR A 1 388 ? 64.023 -61.425  1.400   1.00 73.54  ? 386 TYR A CG  1 
ATOM 2952 C CD1 . TYR A 1 388 ? 63.931 -60.223  2.102   1.00 75.81  ? 386 TYR A CD1 1 
ATOM 2953 C CD2 . TYR A 1 388 ? 63.658 -62.587  2.068   1.00 76.70  ? 386 TYR A CD2 1 
ATOM 2954 C CE1 . TYR A 1 388 ? 63.454 -60.188  3.404   1.00 78.80  ? 386 TYR A CE1 1 
ATOM 2955 C CE2 . TYR A 1 388 ? 63.177 -62.567  3.367   1.00 72.72  ? 386 TYR A CE2 1 
ATOM 2956 C CZ  . TYR A 1 388 ? 63.073 -61.363  4.032   1.00 73.93  ? 386 TYR A CZ  1 
ATOM 2957 O OH  . TYR A 1 388 ? 62.586 -61.384  5.298   1.00 78.13  ? 386 TYR A OH  1 
ATOM 2958 N N   . CYS A 1 389 ? 64.334 -60.109  -3.286  1.00 75.99  ? 387 CYS A N   1 
ATOM 2959 C CA  . CYS A 1 389 ? 64.839 -60.294  -4.640  1.00 72.70  ? 387 CYS A CA  1 
ATOM 2960 C C   . CYS A 1 389 ? 64.453 -59.121  -5.535  1.00 69.16  ? 387 CYS A C   1 
ATOM 2961 O O   . CYS A 1 389 ? 65.318 -58.364  -5.959  1.00 61.16  ? 387 CYS A O   1 
ATOM 2962 C CB  . CYS A 1 389 ? 64.358 -61.602  -5.249  1.00 70.68  ? 387 CYS A CB  1 
ATOM 2963 S SG  . CYS A 1 389 ? 65.141 -61.981  -6.838  1.00 80.00  ? 387 CYS A SG  1 
ATOM 2964 N N   . VAL A 1 390 ? 63.155 -58.958  -5.814  1.00 75.56  ? 388 VAL A N   1 
ATOM 2965 C CA  . VAL A 1 390 ? 62.718 -58.026  -6.844  1.00 70.41  ? 388 VAL A CA  1 
ATOM 2966 C C   . VAL A 1 390 ? 63.263 -56.631  -6.570  1.00 73.93  ? 388 VAL A C   1 
ATOM 2967 O O   . VAL A 1 390 ? 63.937 -56.062  -7.417  1.00 86.13  ? 388 VAL A O   1 
ATOM 2968 C CB  . VAL A 1 390 ? 61.198 -57.974  -7.032  1.00 65.79  ? 388 VAL A CB  1 
ATOM 2969 C CG1 . VAL A 1 390 ? 60.806 -56.800  -7.911  1.00 64.77  ? 388 VAL A CG1 1 
ATOM 2970 C CG2 . VAL A 1 390 ? 60.688 -59.280  -7.632  1.00 73.40  ? 388 VAL A CG2 1 
ATOM 2971 N N   . LYS A 1 391 ? 62.974 -56.091  -5.388  1.00 77.99  ? 389 LYS A N   1 
ATOM 2972 C CA  . LYS A 1 391 ? 63.438 -54.761  -5.028  1.00 76.40  ? 389 LYS A CA  1 
ATOM 2973 C C   . LYS A 1 391 ? 64.958 -54.613  -5.165  1.00 72.57  ? 389 LYS A C   1 
ATOM 2974 O O   . LYS A 1 391 ? 65.431 -53.521  -5.440  1.00 78.24  ? 389 LYS A O   1 
ATOM 2975 C CB  . LYS A 1 391 ? 63.008 -54.415  -3.602  1.00 74.13  ? 389 LYS A CB  1 
ATOM 2976 C CG  . LYS A 1 391 ? 61.606 -53.852  -3.502  1.00 81.52  ? 389 LYS A CG  1 
ATOM 2977 C CD  . LYS A 1 391 ? 61.210 -53.514  -2.069  1.00 81.51  ? 389 LYS A CD  1 
ATOM 2978 C CE  . LYS A 1 391 ? 59.946 -52.732  -1.976  1.00 83.44  ? 389 LYS A CE  1 
ATOM 2979 N NZ  . LYS A 1 391 ? 59.272 -52.990  -0.697  1.00 79.04  ? 389 LYS A NZ  1 
ATOM 2980 N N   . GLY A 1 392 ? 65.728 -55.688  -4.974  1.00 68.93  ? 390 GLY A N   1 
ATOM 2981 C CA  . GLY A 1 392 ? 67.175 -55.561  -4.926  1.00 68.24  ? 390 GLY A CA  1 
ATOM 2982 C C   . GLY A 1 392 ? 67.861 -55.908  -6.245  1.00 75.46  ? 390 GLY A C   1 
ATOM 2983 O O   . GLY A 1 392 ? 69.077 -56.097  -6.258  1.00 81.35  ? 390 GLY A O   1 
ATOM 2984 N N   . ILE A 1 393 ? 67.096 -56.027  -7.341  1.00 80.01  ? 391 ILE A N   1 
ATOM 2985 C CA  . ILE A 1 393 ? 67.672 -56.444  -8.613  1.00 79.24  ? 391 ILE A CA  1 
ATOM 2986 C C   . ILE A 1 393 ? 68.461 -55.281  -9.196  1.00 75.78  ? 391 ILE A C   1 
ATOM 2987 O O   . ILE A 1 393 ? 67.979 -54.148  -9.166  1.00 69.50  ? 391 ILE A O   1 
ATOM 2988 C CB  . ILE A 1 393 ? 66.597 -56.924  -9.606  1.00 77.18  ? 391 ILE A CB  1 
ATOM 2989 C CG1 . ILE A 1 393 ? 65.802 -58.094  -9.044  1.00 75.54  ? 391 ILE A CG1 1 
ATOM 2990 C CG2 . ILE A 1 393 ? 67.228 -57.266  -10.957 1.00 83.55  ? 391 ILE A CG2 1 
ATOM 2991 C CD1 . ILE A 1 393 ? 64.666 -58.565  -9.929  1.00 71.83  ? 391 ILE A CD1 1 
ATOM 2992 N N   . GLU A 1 394 ? 69.650 -55.581  -9.739  1.00 72.03  ? 392 GLU A N   1 
ATOM 2993 C CA  . GLU A 1 394 ? 70.452 -54.564  -10.398 1.00 75.02  ? 392 GLU A CA  1 
ATOM 2994 C C   . GLU A 1 394 ? 70.865 -55.028  -11.793 1.00 75.81  ? 392 GLU A C   1 
ATOM 2995 O O   . GLU A 1 394 ? 70.889 -56.225  -12.070 1.00 69.99  ? 392 GLU A O   1 
ATOM 2996 C CB  . GLU A 1 394 ? 71.604 -54.127  -9.497  1.00 76.96  ? 392 GLU A CB  1 
ATOM 2997 C CG  . GLU A 1 394 ? 71.217 -52.900  -8.684  1.00 79.95  ? 392 GLU A CG  1 
ATOM 2998 C CD  . GLU A 1 394 ? 72.296 -52.499  -7.709  1.00 101.58 ? 392 GLU A CD  1 
ATOM 2999 O OE1 . GLU A 1 394 ? 73.330 -53.205  -7.597  1.00 103.14 ? 392 GLU A OE1 1 
ATOM 3000 O OE2 . GLU A 1 394 ? 72.081 -51.454  -7.060  1.00 128.61 ? 392 GLU A OE2 1 
ATOM 3001 N N   . ALA A 1 395 ? 71.190 -54.040  -12.644 1.00 70.52  ? 393 ALA A N   1 
ATOM 3002 C CA  . ALA A 1 395 ? 71.485 -54.241  -14.054 1.00 70.62  ? 393 ALA A CA  1 
ATOM 3003 C C   . ALA A 1 395 ? 72.988 -54.223  -14.318 1.00 72.63  ? 393 ALA A C   1 
ATOM 3004 O O   . ALA A 1 395 ? 73.703 -53.485  -13.648 1.00 90.05  ? 393 ALA A O   1 
ATOM 3005 C CB  . ALA A 1 395 ? 70.824 -53.133  -14.830 1.00 71.56  ? 393 ALA A CB  1 
ATOM 3006 N N   . ASN A 1 396 ? 73.451 -54.973  -15.333 1.00 70.61  ? 394 ASN A N   1 
ATOM 3007 C CA  . ASN A 1 396 ? 74.826 -54.859  -15.812 1.00 75.80  ? 394 ASN A CA  1 
ATOM 3008 C C   . ASN A 1 396 ? 74.852 -54.135  -17.152 1.00 73.88  ? 394 ASN A C   1 
ATOM 3009 O O   . ASN A 1 396 ? 75.277 -54.707  -18.132 1.00 91.67  ? 394 ASN A O   1 
ATOM 3010 C CB  . ASN A 1 396 ? 75.515 -56.209  -15.979 1.00 76.65  ? 394 ASN A CB  1 
ATOM 3011 C CG  . ASN A 1 396 ? 75.644 -56.947  -14.671 1.00 85.31  ? 394 ASN A CG  1 
ATOM 3012 O OD1 . ASN A 1 396 ? 75.607 -56.329  -13.597 1.00 79.37  ? 394 ASN A OD1 1 
ATOM 3013 N ND2 . ASN A 1 396 ? 75.798 -58.265  -14.736 1.00 87.94  ? 394 ASN A ND2 1 
ATOM 3014 N N   . GLU A 1 397 ? 74.459 -52.863  -17.159 1.00 77.30  ? 395 GLU A N   1 
ATOM 3015 C CA  . GLU A 1 397 ? 74.158 -52.107  -18.365 1.00 84.82  ? 395 GLU A CA  1 
ATOM 3016 C C   . GLU A 1 397 ? 75.325 -52.074  -19.351 1.00 88.32  ? 395 GLU A C   1 
ATOM 3017 O O   . GLU A 1 397 ? 75.085 -51.897  -20.542 1.00 87.10  ? 395 GLU A O   1 
ATOM 3018 C CB  . GLU A 1 397 ? 73.695 -50.695  -17.985 1.00 94.87  ? 395 GLU A CB  1 
ATOM 3019 C CG  . GLU A 1 397 ? 74.690 -49.924  -17.119 1.00 103.79 ? 395 GLU A CG  1 
ATOM 3020 C CD  . GLU A 1 397 ? 74.069 -49.094  -15.998 1.00 116.85 ? 395 GLU A CD  1 
ATOM 3021 O OE1 . GLU A 1 397 ? 74.102 -49.536  -14.817 1.00 115.39 ? 395 GLU A OE1 1 
ATOM 3022 O OE2 . GLU A 1 397 ? 73.588 -47.984  -16.313 1.00 121.23 ? 395 GLU A OE2 1 
ATOM 3023 N N   . GLU A 1 398 ? 76.576 -52.190  -18.884 1.00 95.50  ? 396 GLU A N   1 
ATOM 3024 C CA  . GLU A 1 398 ? 77.700 -52.215  -19.810 1.00 94.87  ? 396 GLU A CA  1 
ATOM 3025 C C   . GLU A 1 398 ? 77.814 -53.577  -20.492 1.00 87.85  ? 396 GLU A C   1 
ATOM 3026 O O   . GLU A 1 398 ? 78.217 -53.648  -21.647 1.00 90.06  ? 396 GLU A O   1 
ATOM 3027 C CB  . GLU A 1 398 ? 79.011 -51.768  -19.163 1.00 103.27 ? 396 GLU A CB  1 
ATOM 3028 C CG  . GLU A 1 398 ? 79.085 -50.256  -18.946 1.00 112.54 ? 396 GLU A CG  1 
ATOM 3029 C CD  . GLU A 1 398 ? 78.851 -49.361  -20.160 1.00 104.70 ? 396 GLU A CD  1 
ATOM 3030 O OE1 . GLU A 1 398 ? 79.565 -49.561  -21.160 1.00 104.78 ? 396 GLU A OE1 1 
ATOM 3031 O OE2 . GLU A 1 398 ? 77.984 -48.456  -20.114 1.00 96.74  ? 396 GLU A OE2 1 
ATOM 3032 N N   . LYS A 1 399 ? 77.448 -54.653  -19.790 1.00 84.71  ? 397 LYS A N   1 
ATOM 3033 C CA  . LYS A 1 399 ? 77.390 -55.984  -20.384 1.00 77.70  ? 397 LYS A CA  1 
ATOM 3034 C C   . LYS A 1 399 ? 76.279 -56.021  -21.433 1.00 75.02  ? 397 LYS A C   1 
ATOM 3035 O O   . LYS A 1 399 ? 76.457 -56.605  -22.493 1.00 81.34  ? 397 LYS A O   1 
ATOM 3036 C CB  . LYS A 1 399 ? 77.112 -57.059  -19.318 1.00 82.46  ? 397 LYS A CB  1 
ATOM 3037 C CG  . LYS A 1 399 ? 77.821 -58.397  -19.431 1.00 84.65  ? 397 LYS A CG  1 
ATOM 3038 C CD  . LYS A 1 399 ? 77.906 -58.980  -20.836 1.00 93.80  ? 397 LYS A CD  1 
ATOM 3039 C CE  . LYS A 1 399 ? 78.882 -60.119  -20.914 1.00 101.51 ? 397 LYS A CE  1 
ATOM 3040 N NZ  . LYS A 1 399 ? 78.487 -61.248  -20.067 1.00 101.30 ? 397 LYS A NZ  1 
ATOM 3041 N N   . MET A 1 400 ? 75.136 -55.391  -21.118 1.00 85.89  ? 398 MET A N   1 
ATOM 3042 C CA  . MET A 1 400 ? 73.935 -55.420  -21.947 1.00 89.82  ? 398 MET A CA  1 
ATOM 3043 C C   . MET A 1 400 ? 74.125 -54.565  -23.196 1.00 88.43  ? 398 MET A C   1 
ATOM 3044 O O   . MET A 1 400 ? 73.714 -54.969  -24.280 1.00 85.64  ? 398 MET A O   1 
ATOM 3045 C CB  . MET A 1 400 ? 72.692 -54.905  -21.197 1.00 89.27  ? 398 MET A CB  1 
ATOM 3046 C CG  . MET A 1 400 ? 72.064 -55.914  -20.227 1.00 86.07  ? 398 MET A CG  1 
ATOM 3047 S SD  . MET A 1 400 ? 70.529 -55.411  -19.419 1.00 89.47  ? 398 MET A SD  1 
ATOM 3048 C CE  . MET A 1 400 ? 70.992 -53.909  -18.542 1.00 90.78  ? 398 MET A CE  1 
ATOM 3049 N N   . LYS A 1 401 ? 74.721 -53.374  -23.029 1.00 89.06  ? 399 LYS A N   1 
ATOM 3050 C CA  . LYS A 1 401 ? 74.984 -52.490  -24.153 1.00 82.98  ? 399 LYS A CA  1 
ATOM 3051 C C   . LYS A 1 401 ? 76.003 -53.142  -25.085 1.00 87.40  ? 399 LYS A C   1 
ATOM 3052 O O   . LYS A 1 401 ? 75.862 -53.048  -26.302 1.00 84.16  ? 399 LYS A O   1 
ATOM 3053 C CB  . LYS A 1 401 ? 75.489 -51.118  -23.703 1.00 87.82  ? 399 LYS A CB  1 
ATOM 3054 C CG  . LYS A 1 401 ? 75.556 -50.056  -24.800 1.00 100.53 ? 399 LYS A CG  1 
ATOM 3055 C CD  . LYS A 1 401 ? 75.907 -48.667  -24.274 1.00 108.69 ? 399 LYS A CD  1 
ATOM 3056 C CE  . LYS A 1 401 ? 74.797 -48.050  -23.476 1.00 114.97 ? 399 LYS A CE  1 
ATOM 3057 N NZ  . LYS A 1 401 ? 75.326 -47.084  -22.508 1.00 125.09 ? 399 LYS A NZ  1 
ATOM 3058 N N   . GLU A 1 402 ? 77.008 -53.817  -24.506 1.00 91.77  ? 400 GLU A N   1 
ATOM 3059 C CA  . GLU A 1 402 ? 78.024 -54.519  -25.277 1.00 98.79  ? 400 GLU A CA  1 
ATOM 3060 C C   . GLU A 1 402 ? 77.400 -55.521  -26.246 1.00 96.14  ? 400 GLU A C   1 
ATOM 3061 O O   . GLU A 1 402 ? 77.845 -55.627  -27.381 1.00 116.48 ? 400 GLU A O   1 
ATOM 3062 C CB  . GLU A 1 402 ? 79.007 -55.316  -24.425 1.00 102.94 ? 400 GLU A CB  1 
ATOM 3063 C CG  . GLU A 1 402 ? 80.265 -55.668  -25.203 1.00 113.50 ? 400 GLU A CG  1 
ATOM 3064 C CD  . GLU A 1 402 ? 81.178 -56.647  -24.509 1.00 122.35 ? 400 GLU A CD  1 
ATOM 3065 O OE1 . GLU A 1 402 ? 81.127 -56.829  -23.265 1.00 118.20 ? 400 GLU A OE1 1 
ATOM 3066 O OE2 . GLU A 1 402 ? 81.944 -57.246  -25.283 1.00 133.32 ? 400 GLU A OE2 1 
ATOM 3067 N N   . TYR A 1 403 ? 76.398 -56.279  -25.789 1.00 95.48  ? 401 TYR A N   1 
ATOM 3068 C CA  . TYR A 1 403 ? 75.711 -57.245  -26.632 1.00 92.73  ? 401 TYR A CA  1 
ATOM 3069 C C   . TYR A 1 403 ? 75.088 -56.547  -27.845 1.00 91.85  ? 401 TYR A C   1 
ATOM 3070 O O   . TYR A 1 403 ? 75.125 -57.106  -28.937 1.00 103.40 ? 401 TYR A O   1 
ATOM 3071 C CB  . TYR A 1 403 ? 74.626 -58.007  -25.860 1.00 95.93  ? 401 TYR A CB  1 
ATOM 3072 C CG  . TYR A 1 403 ? 75.065 -59.097  -24.889 1.00 94.00  ? 401 TYR A CG  1 
ATOM 3073 C CD1 . TYR A 1 403 ? 76.219 -59.855  -25.101 1.00 90.62  ? 401 TYR A CD1 1 
ATOM 3074 C CD2 . TYR A 1 403 ? 74.296 -59.387  -23.761 1.00 81.96  ? 401 TYR A CD2 1 
ATOM 3075 C CE1 . TYR A 1 403 ? 76.593 -60.862  -24.218 1.00 86.19  ? 401 TYR A CE1 1 
ATOM 3076 C CE2 . TYR A 1 403 ? 74.666 -60.394  -22.876 1.00 75.98  ? 401 TYR A CE2 1 
ATOM 3077 C CZ  . TYR A 1 403 ? 75.814 -61.135  -23.103 1.00 75.54  ? 401 TYR A CZ  1 
ATOM 3078 O OH  . TYR A 1 403 ? 76.163 -62.141  -22.249 1.00 69.20  ? 401 TYR A OH  1 
ATOM 3079 N N   . VAL A 1 404 ? 74.507 -55.345  -27.662 1.00 86.99  ? 402 VAL A N   1 
ATOM 3080 C CA  . VAL A 1 404 ? 73.865 -54.627  -28.762 1.00 81.43  ? 402 VAL A CA  1 
ATOM 3081 C C   . VAL A 1 404 ? 74.931 -54.284  -29.794 1.00 84.39  ? 402 VAL A C   1 
ATOM 3082 O O   . VAL A 1 404 ? 74.759 -54.564  -30.978 1.00 70.93  ? 402 VAL A O   1 
ATOM 3083 C CB  . VAL A 1 404 ? 73.122 -53.333  -28.379 1.00 75.21  ? 402 VAL A CB  1 
ATOM 3084 C CG1 . VAL A 1 404 ? 72.542 -52.648  -29.615 1.00 69.03  ? 402 VAL A CG1 1 
ATOM 3085 C CG2 . VAL A 1 404 ? 72.044 -53.568  -27.321 1.00 79.38  ? 402 VAL A CG2 1 
ATOM 3086 N N   . GLU A 1 405 ? 76.032 -53.700  -29.295 1.00 95.26  ? 403 GLU A N   1 
ATOM 3087 C CA  . GLU A 1 405 ? 77.111 -53.160  -30.108 1.00 91.30  ? 403 GLU A CA  1 
ATOM 3088 C C   . GLU A 1 405 ? 77.803 -54.233  -30.941 1.00 87.48  ? 403 GLU A C   1 
ATOM 3089 O O   . GLU A 1 405 ? 78.490 -53.889  -31.892 1.00 91.56  ? 403 GLU A O   1 
ATOM 3090 C CB  . GLU A 1 405 ? 78.195 -52.501  -29.253 1.00 91.27  ? 403 GLU A CB  1 
ATOM 3091 C CG  . GLU A 1 405 ? 77.803 -51.119  -28.744 1.00 99.82  ? 403 GLU A CG  1 
ATOM 3092 C CD  . GLU A 1 405 ? 77.673 -50.061  -29.833 1.00 110.72 ? 403 GLU A CD  1 
ATOM 3093 O OE1 . GLU A 1 405 ? 77.802 -48.885  -29.443 1.00 128.13 ? 403 GLU A OE1 1 
ATOM 3094 O OE2 . GLU A 1 405 ? 77.434 -50.355  -31.032 1.00 101.87 ? 403 GLU A OE2 1 
ATOM 3095 N N   . LYS A 1 406 ? 77.662 -55.510  -30.569 1.00 85.87  ? 404 LYS A N   1 
ATOM 3096 C CA  . LYS A 1 406 ? 78.301 -56.583  -31.314 1.00 90.93  ? 404 LYS A CA  1 
ATOM 3097 C C   . LYS A 1 406 ? 77.229 -57.528  -31.838 1.00 90.94  ? 404 LYS A C   1 
ATOM 3098 O O   . LYS A 1 406 ? 77.406 -58.740  -31.813 1.00 96.55  ? 404 LYS A O   1 
ATOM 3099 C CB  . LYS A 1 406 ? 79.330 -57.341  -30.461 1.00 98.50  ? 404 LYS A CB  1 
ATOM 3100 C CG  . LYS A 1 406 ? 80.413 -56.492  -29.769 1.00 114.11 ? 404 LYS A CG  1 
ATOM 3101 C CD  . LYS A 1 406 ? 81.273 -55.552  -30.624 1.00 126.34 ? 404 LYS A CD  1 
ATOM 3102 C CE  . LYS A 1 406 ? 82.215 -56.190  -31.631 1.00 120.89 ? 404 LYS A CE  1 
ATOM 3103 N NZ  . LYS A 1 406 ? 83.486 -56.684  -31.083 1.00 107.70 ? 404 LYS A NZ  1 
ATOM 3104 N N   . SER A 1 407 ? 76.131 -56.962  -32.342 1.00 92.11  ? 405 SER A N   1 
ATOM 3105 C CA  . SER A 1 407 ? 74.941 -57.742  -32.607 1.00 97.22  ? 405 SER A CA  1 
ATOM 3106 C C   . SER A 1 407 ? 74.485 -57.485  -34.032 1.00 96.86  ? 405 SER A C   1 
ATOM 3107 O O   . SER A 1 407 ? 74.397 -56.337  -34.458 1.00 91.58  ? 405 SER A O   1 
ATOM 3108 C CB  . SER A 1 407 ? 73.846 -57.435  -31.636 1.00 105.71 ? 405 SER A CB  1 
ATOM 3109 O OG  . SER A 1 407 ? 73.022 -58.579  -31.452 1.00 126.01 ? 405 SER A OG  1 
ATOM 3110 N N   . VAL A 1 408 ? 74.220 -58.585  -34.733 1.00 104.71 ? 406 VAL A N   1 
ATOM 3111 C CA  . VAL A 1 408 ? 73.848 -58.554  -36.133 1.00 101.66 ? 406 VAL A CA  1 
ATOM 3112 C C   . VAL A 1 408 ? 72.465 -57.922  -36.252 1.00 96.86  ? 406 VAL A C   1 
ATOM 3113 O O   . VAL A 1 408 ? 72.268 -57.034  -37.087 1.00 99.04  ? 406 VAL A O   1 
ATOM 3114 C CB  . VAL A 1 408 ? 73.896 -59.992  -36.685 1.00 106.10 ? 406 VAL A CB  1 
ATOM 3115 C CG1 . VAL A 1 408 ? 73.395 -60.063  -38.120 1.00 111.07 ? 406 VAL A CG1 1 
ATOM 3116 C CG2 . VAL A 1 408 ? 75.289 -60.601  -36.542 1.00 104.72 ? 406 VAL A CG2 1 
ATOM 3117 N N   . GLY A 1 409 ? 71.536 -58.341  -35.370 1.00 87.44  ? 407 GLY A N   1 
ATOM 3118 C CA  . GLY A 1 409 ? 70.127 -57.976  -35.446 1.00 87.87  ? 407 GLY A CA  1 
ATOM 3119 C C   . GLY A 1 409 ? 69.876 -56.463  -35.464 1.00 90.19  ? 407 GLY A C   1 
ATOM 3120 O O   . GLY A 1 409 ? 68.779 -56.027  -35.833 1.00 69.72  ? 407 GLY A O   1 
ATOM 3121 N N   . VAL A 1 410 ? 70.888 -55.682  -35.040 1.00 97.39  ? 408 VAL A N   1 
ATOM 3122 C CA  . VAL A 1 410 ? 70.852 -54.227  -35.035 1.00 97.57  ? 408 VAL A CA  1 
ATOM 3123 C C   . VAL A 1 410 ? 70.686 -53.687  -36.457 1.00 109.63 ? 408 VAL A C   1 
ATOM 3124 O O   . VAL A 1 410 ? 70.321 -52.524  -36.626 1.00 104.00 ? 408 VAL A O   1 
ATOM 3125 C CB  . VAL A 1 410 ? 72.136 -53.699  -34.356 1.00 92.02  ? 408 VAL A CB  1 
ATOM 3126 C CG1 . VAL A 1 410 ? 72.371 -52.202  -34.544 1.00 88.48  ? 408 VAL A CG1 1 
ATOM 3127 C CG2 . VAL A 1 410 ? 72.167 -54.048  -32.872 1.00 94.18  ? 408 VAL A CG2 1 
ATOM 3128 N N   . ILE A 1 411 ? 70.948 -54.535  -37.466 1.00 123.18 ? 409 ILE A N   1 
ATOM 3129 C CA  . ILE A 1 411 ? 70.884 -54.152  -38.869 1.00 122.57 ? 409 ILE A CA  1 
ATOM 3130 C C   . ILE A 1 411 ? 69.443 -53.850  -39.278 1.00 113.11 ? 409 ILE A C   1 
ATOM 3131 O O   . ILE A 1 411 ? 69.226 -53.203  -40.297 1.00 129.32 ? 409 ILE A O   1 
ATOM 3132 C CB  . ILE A 1 411 ? 71.497 -55.249  -39.762 1.00 128.23 ? 409 ILE A CB  1 
ATOM 3133 C CG1 . ILE A 1 411 ? 71.917 -54.708  -41.143 1.00 147.29 ? 409 ILE A CG1 1 
ATOM 3134 C CG2 . ILE A 1 411 ? 70.549 -56.445  -39.889 1.00 114.05 ? 409 ILE A CG2 1 
ATOM 3135 C CD1 . ILE A 1 411 ? 73.147 -53.816  -41.131 1.00 149.80 ? 409 ILE A CD1 1 
ATOM 3136 N N   . THR A 1 412 ? 68.470 -54.352  -38.505 1.00 108.65 ? 410 THR A N   1 
ATOM 3137 C CA  . THR A 1 412 ? 67.065 -54.134  -38.813 1.00 117.34 ? 410 THR A CA  1 
ATOM 3138 C C   . THR A 1 412 ? 66.732 -52.650  -38.624 1.00 119.28 ? 410 THR A C   1 
ATOM 3139 O O   . THR A 1 412 ? 65.740 -52.176  -39.181 1.00 101.28 ? 410 THR A O   1 
ATOM 3140 C CB  . THR A 1 412 ? 66.180 -55.044  -37.949 1.00 118.18 ? 410 THR A CB  1 
ATOM 3141 O OG1 . THR A 1 412 ? 66.645 -56.389  -38.021 1.00 110.92 ? 410 THR A OG1 1 
ATOM 3142 C CG2 . THR A 1 412 ? 64.729 -55.064  -38.397 1.00 116.53 ? 410 THR A CG2 1 
ATOM 3143 N N   . ALA A 1 413 ? 67.563 -51.921  -37.857 1.00 132.58 ? 411 ALA A N   1 
ATOM 3144 C CA  . ALA A 1 413 ? 67.279 -50.542  -37.470 1.00 151.19 ? 411 ALA A CA  1 
ATOM 3145 C C   . ALA A 1 413 ? 67.844 -49.536  -38.481 1.00 155.56 ? 411 ALA A C   1 
ATOM 3146 O O   . ALA A 1 413 ? 67.284 -48.451  -38.653 1.00 127.52 ? 411 ALA A O   1 
ATOM 3147 C CB  . ALA A 1 413 ? 67.826 -50.289  -36.076 1.00 149.21 ? 411 ALA A CB  1 
ATOM 3148 N N   . VAL A 1 414 ? 68.976 -49.896  -39.114 1.00 167.92 ? 412 VAL A N   1 
ATOM 3149 C CA  . VAL A 1 414 ? 69.652 -49.052  -40.098 1.00 149.22 ? 412 VAL A CA  1 
ATOM 3150 C C   . VAL A 1 414 ? 69.247 -49.475  -41.512 1.00 139.06 ? 412 VAL A C   1 
ATOM 3151 O O   . VAL A 1 414 ? 69.839 -49.012  -42.485 1.00 142.38 ? 412 VAL A O   1 
ATOM 3152 C CB  . VAL A 1 414 ? 71.187 -49.097  -39.936 1.00 138.35 ? 412 VAL A CB  1 
ATOM 3153 C CG1 . VAL A 1 414 ? 71.631 -48.516  -38.599 1.00 129.17 ? 412 VAL A CG1 1 
ATOM 3154 C CG2 . VAL A 1 414 ? 71.747 -50.504  -40.120 1.00 132.56 ? 412 VAL A CG2 1 
ATOM 3155 N N   . ASN A 1 415 ? 68.223 -50.337  -41.609 1.00 132.32 ? 413 ASN A N   1 
ATOM 3156 C CA  . ASN A 1 415 ? 67.740 -50.926  -42.852 1.00 116.36 ? 413 ASN A CA  1 
ATOM 3157 C C   . ASN A 1 415 ? 67.060 -49.865  -43.733 1.00 117.94 ? 413 ASN A C   1 
ATOM 3158 O O   . ASN A 1 415 ? 67.372 -49.761  -44.921 1.00 136.41 ? 413 ASN A O   1 
ATOM 3159 C CB  . ASN A 1 415 ? 66.848 -52.122  -42.508 1.00 106.13 ? 413 ASN A CB  1 
ATOM 3160 C CG  . ASN A 1 415 ? 66.462 -52.945  -43.708 1.00 96.27  ? 413 ASN A CG  1 
ATOM 3161 O OD1 . ASN A 1 415 ? 67.360 -53.459  -44.378 1.00 96.60  ? 413 ASN A OD1 1 
ATOM 3162 N ND2 . ASN A 1 415 ? 65.169 -53.080  -43.995 1.00 92.64  ? 413 ASN A ND2 1 
ATOM 3163 N N   . PRO A 1 416 ? 66.082 -49.076  -43.221 1.00 117.97 ? 414 PRO A N   1 
ATOM 3164 C CA  . PRO A 1 416 ? 65.394 -48.077  -44.049 1.00 113.05 ? 414 PRO A CA  1 
ATOM 3165 C C   . PRO A 1 416 ? 66.220 -46.922  -44.617 1.00 114.06 ? 414 PRO A C   1 
ATOM 3166 O O   . PRO A 1 416 ? 65.743 -46.261  -45.531 1.00 117.81 ? 414 PRO A O   1 
ATOM 3167 C CB  . PRO A 1 416 ? 64.271 -47.540  -43.135 1.00 123.47 ? 414 PRO A CB  1 
ATOM 3168 C CG  . PRO A 1 416 ? 64.673 -47.948  -41.719 1.00 132.59 ? 414 PRO A CG  1 
ATOM 3169 C CD  . PRO A 1 416 ? 65.553 -49.152  -41.846 1.00 126.34 ? 414 PRO A CD  1 
ATOM 3170 N N   . HIS A 1 417 ? 67.440 -46.693  -44.089 1.00 126.45 ? 415 HIS A N   1 
ATOM 3171 C CA  . HIS A 1 417 ? 68.297 -45.586  -44.507 1.00 131.51 ? 415 HIS A CA  1 
ATOM 3172 C C   . HIS A 1 417 ? 69.399 -46.030  -45.482 1.00 136.03 ? 415 HIS A C   1 
ATOM 3173 O O   . HIS A 1 417 ? 69.997 -45.201  -46.173 1.00 109.44 ? 415 HIS A O   1 
ATOM 3174 C CB  . HIS A 1 417 ? 68.995 -44.938  -43.306 1.00 133.17 ? 415 HIS A CB  1 
ATOM 3175 C CG  . HIS A 1 417 ? 68.180 -44.817  -42.064 1.00 129.05 ? 415 HIS A CG  1 
ATOM 3176 N ND1 . HIS A 1 417 ? 68.523 -45.485  -40.907 1.00 132.39 ? 415 HIS A ND1 1 
ATOM 3177 C CD2 . HIS A 1 417 ? 67.097 -44.087  -41.767 1.00 121.38 ? 415 HIS A CD2 1 
ATOM 3178 C CE1 . HIS A 1 417 ? 67.658 -45.172  -39.949 1.00 125.84 ? 415 HIS A CE1 1 
ATOM 3179 N NE2 . HIS A 1 417 ? 66.779 -44.329  -40.453 1.00 121.45 ? 415 HIS A NE2 1 
ATOM 3180 N N   . ILE A 1 418 ? 69.694 -47.340  -45.508 1.00 141.58 ? 416 ILE A N   1 
ATOM 3181 C CA  . ILE A 1 418 ? 70.668 -47.917  -46.421 1.00 118.83 ? 416 ILE A CA  1 
ATOM 3182 C C   . ILE A 1 418 ? 69.963 -48.645  -47.565 1.00 119.39 ? 416 ILE A C   1 
ATOM 3183 O O   . ILE A 1 418 ? 70.532 -48.790  -48.646 1.00 116.41 ? 416 ILE A O   1 
ATOM 3184 C CB  . ILE A 1 418 ? 71.587 -48.895  -45.673 1.00 122.87 ? 416 ILE A CB  1 
ATOM 3185 C CG1 . ILE A 1 418 ? 72.276 -48.281  -44.468 1.00 130.28 ? 416 ILE A CG1 1 
ATOM 3186 C CG2 . ILE A 1 418 ? 72.599 -49.471  -46.649 1.00 138.52 ? 416 ILE A CG2 1 
ATOM 3187 C CD1 . ILE A 1 418 ? 73.180 -49.259  -43.734 1.00 131.34 ? 416 ILE A CD1 1 
ATOM 3188 N N   . GLY A 1 419 ? 68.744 -49.151  -47.315 1.00 134.11 ? 417 GLY A N   1 
ATOM 3189 C CA  . GLY A 1 419 ? 68.049 -50.033  -48.244 1.00 140.36 ? 417 GLY A CA  1 
ATOM 3190 C C   . GLY A 1 419 ? 68.473 -51.495  -48.073 1.00 139.12 ? 417 GLY A C   1 
ATOM 3191 O O   . GLY A 1 419 ? 69.610 -51.761  -47.692 1.00 135.86 ? 417 GLY A O   1 
ATOM 3192 N N   . TYR A 1 420 ? 67.566 -52.428  -48.413 1.00 128.15 ? 418 TYR A N   1 
ATOM 3193 C CA  . TYR A 1 420 ? 67.746 -53.852  -48.163 1.00 146.78 ? 418 TYR A CA  1 
ATOM 3194 C C   . TYR A 1 420 ? 68.993 -54.406  -48.865 1.00 165.71 ? 418 TYR A C   1 
ATOM 3195 O O   . TYR A 1 420 ? 69.612 -55.339  -48.353 1.00 180.50 ? 418 TYR A O   1 
ATOM 3196 C CB  . TYR A 1 420 ? 66.466 -54.596  -48.574 1.00 153.77 ? 418 TYR A CB  1 
ATOM 3197 C CG  . TYR A 1 420 ? 66.467 -56.113  -48.383 1.00 162.22 ? 418 TYR A CG  1 
ATOM 3198 C CD1 . TYR A 1 420 ? 66.972 -56.965  -49.367 1.00 148.97 ? 418 TYR A CD1 1 
ATOM 3199 C CD2 . TYR A 1 420 ? 65.939 -56.698  -47.232 1.00 146.64 ? 418 TYR A CD2 1 
ATOM 3200 C CE1 . TYR A 1 420 ? 66.974 -58.342  -49.202 1.00 137.49 ? 418 TYR A CE1 1 
ATOM 3201 C CE2 . TYR A 1 420 ? 65.932 -58.075  -47.057 1.00 134.21 ? 418 TYR A CE2 1 
ATOM 3202 C CZ  . TYR A 1 420 ? 66.449 -58.897  -48.046 1.00 136.61 ? 418 TYR A CZ  1 
ATOM 3203 O OH  . TYR A 1 420 ? 66.417 -60.249  -47.881 1.00 107.07 ? 418 TYR A OH  1 
ATOM 3204 N N   . GLU A 1 421 ? 69.364 -53.852  -50.029 1.00 171.04 ? 419 GLU A N   1 
ATOM 3205 C CA  . GLU A 1 421 ? 70.430 -54.417  -50.849 1.00 159.25 ? 419 GLU A CA  1 
ATOM 3206 C C   . GLU A 1 421 ? 71.801 -54.140  -50.229 1.00 156.72 ? 419 GLU A C   1 
ATOM 3207 O O   . GLU A 1 421 ? 72.636 -55.042  -50.136 1.00 174.16 ? 419 GLU A O   1 
ATOM 3208 C CB  . GLU A 1 421 ? 70.368 -53.843  -52.268 1.00 149.01 ? 419 GLU A CB  1 
ATOM 3209 C CG  . GLU A 1 421 ? 69.242 -54.417  -53.124 1.00 151.13 ? 419 GLU A CG  1 
ATOM 3210 C CD  . GLU A 1 421 ? 68.621 -53.466  -54.139 1.00 147.41 ? 419 GLU A CD  1 
ATOM 3211 O OE1 . GLU A 1 421 ? 68.953 -52.258  -54.124 1.00 141.83 ? 419 GLU A OE1 1 
ATOM 3212 O OE2 . GLU A 1 421 ? 67.773 -53.947  -54.919 1.00 138.26 ? 419 GLU A OE2 1 
ATOM 3213 N N   . VAL A 1 422 ? 72.024 -52.883  -49.808 1.00 132.71 ? 420 VAL A N   1 
ATOM 3214 C CA  . VAL A 1 422 ? 73.329 -52.450  -49.329 1.00 120.85 ? 420 VAL A CA  1 
ATOM 3215 C C   . VAL A 1 422 ? 73.565 -52.980  -47.913 1.00 129.61 ? 420 VAL A C   1 
ATOM 3216 O O   . VAL A 1 422 ? 74.714 -53.154  -47.510 1.00 123.58 ? 420 VAL A O   1 
ATOM 3217 C CB  . VAL A 1 422 ? 73.472 -50.916  -49.414 1.00 110.49 ? 420 VAL A CB  1 
ATOM 3218 C CG1 . VAL A 1 422 ? 74.778 -50.416  -48.802 1.00 108.41 ? 420 VAL A CG1 1 
ATOM 3219 C CG2 . VAL A 1 422 ? 73.352 -50.423  -50.849 1.00 115.53 ? 420 VAL A CG2 1 
ATOM 3220 N N   . ALA A 1 423 ? 72.475 -53.222  -47.162 1.00 147.02 ? 421 ALA A N   1 
ATOM 3221 C CA  . ALA A 1 423 ? 72.546 -53.674  -45.775 1.00 138.54 ? 421 ALA A CA  1 
ATOM 3222 C C   . ALA A 1 423 ? 72.601 -55.200  -45.684 1.00 147.80 ? 421 ALA A C   1 
ATOM 3223 O O   . ALA A 1 423 ? 73.115 -55.710  -44.686 1.00 157.40 ? 421 ALA A O   1 
ATOM 3224 C CB  . ALA A 1 423 ? 71.379 -53.128  -44.972 1.00 125.61 ? 421 ALA A CB  1 
ATOM 3225 N N   . SER A 1 424 ? 72.088 -55.922  -46.703 1.00 140.03 ? 422 SER A N   1 
ATOM 3226 C CA  . SER A 1 424 ? 72.216 -57.376  -46.772 1.00 118.73 ? 422 SER A CA  1 
ATOM 3227 C C   . SER A 1 424 ? 73.694 -57.794  -46.786 1.00 120.32 ? 422 SER A C   1 
ATOM 3228 O O   . SER A 1 424 ? 74.075 -58.797  -46.170 1.00 112.92 ? 422 SER A O   1 
ATOM 3229 C CB  . SER A 1 424 ? 71.466 -57.950  -47.973 1.00 105.96 ? 422 SER A CB  1 
ATOM 3230 O OG  . SER A 1 424 ? 70.068 -58.114  -47.746 1.00 99.99  ? 422 SER A OG  1 
ATOM 3231 N N   . ARG A 1 425 ? 74.509 -57.003  -47.506 1.00 125.59 ? 423 ARG A N   1 
ATOM 3232 C CA  . ARG A 1 425 ? 75.931 -57.265  -47.679 1.00 124.94 ? 423 ARG A CA  1 
ATOM 3233 C C   . ARG A 1 425 ? 76.724 -56.804  -46.451 1.00 126.22 ? 423 ARG A C   1 
ATOM 3234 O O   . ARG A 1 425 ? 77.695 -57.455  -46.091 1.00 110.63 ? 423 ARG A O   1 
ATOM 3235 C CB  . ARG A 1 425 ? 76.477 -56.615  -48.962 1.00 121.52 ? 423 ARG A CB  1 
ATOM 3236 C CG  . ARG A 1 425 ? 76.606 -57.444  -50.234 1.00 110.21 ? 423 ARG A CG  1 
ATOM 3237 C CD  . ARG A 1 425 ? 77.471 -56.672  -51.237 1.00 114.48 ? 423 ARG A CD  1 
ATOM 3238 N NE  . ARG A 1 425 ? 76.739 -55.532  -51.809 1.00 123.85 ? 423 ARG A NE  1 
ATOM 3239 C CZ  . ARG A 1 425 ? 76.754 -54.254  -51.403 1.00 117.50 ? 423 ARG A CZ  1 
ATOM 3240 N NH1 . ARG A 1 425 ? 77.482 -53.884  -50.363 1.00 118.06 ? 423 ARG A NH1 1 
ATOM 3241 N NH2 . ARG A 1 425 ? 76.018 -53.346  -52.031 1.00 99.84  ? 423 ARG A NH2 1 
ATOM 3242 N N   . ILE A 1 426 ? 76.337 -55.682  -45.824 1.00 133.53 ? 424 ILE A N   1 
ATOM 3243 C CA  . ILE A 1 426 ? 76.981 -55.200  -44.603 1.00 144.48 ? 424 ILE A CA  1 
ATOM 3244 C C   . ILE A 1 426 ? 76.716 -56.176  -43.452 1.00 153.04 ? 424 ILE A C   1 
ATOM 3245 O O   . ILE A 1 426 ? 77.539 -56.294  -42.544 1.00 141.84 ? 424 ILE A O   1 
ATOM 3246 C CB  . ILE A 1 426 ? 76.522 -53.771  -44.234 1.00 147.09 ? 424 ILE A CB  1 
ATOM 3247 C CG1 . ILE A 1 426 ? 76.940 -52.732  -45.278 1.00 139.46 ? 424 ILE A CG1 1 
ATOM 3248 C CG2 . ILE A 1 426 ? 77.035 -53.376  -42.844 1.00 141.46 ? 424 ILE A CG2 1 
ATOM 3249 C CD1 . ILE A 1 426 ? 76.275 -51.377  -45.096 1.00 130.77 ? 424 ILE A CD1 1 
ATOM 3250 N N   . ALA A 1 427 ? 75.555 -56.852  -43.492 1.00 172.48 ? 425 ALA A N   1 
ATOM 3251 C CA  . ALA A 1 427 ? 75.122 -57.772  -42.449 1.00 176.56 ? 425 ALA A CA  1 
ATOM 3252 C C   . ALA A 1 427 ? 75.830 -59.120  -42.574 1.00 167.62 ? 425 ALA A C   1 
ATOM 3253 O O   . ALA A 1 427 ? 76.165 -59.740  -41.564 1.00 164.23 ? 425 ALA A O   1 
ATOM 3254 C CB  . ALA A 1 427 ? 73.621 -57.957  -42.523 1.00 178.85 ? 425 ALA A CB  1 
ATOM 3255 N N   . ARG A 1 428 ? 76.022 -59.577  -43.817 1.00 157.39 ? 426 ARG A N   1 
ATOM 3256 C CA  . ARG A 1 428 ? 76.746 -60.811  -44.075 1.00 156.00 ? 426 ARG A CA  1 
ATOM 3257 C C   . ARG A 1 428 ? 78.233 -60.621  -43.745 1.00 157.09 ? 426 ARG A C   1 
ATOM 3258 O O   . ARG A 1 428 ? 78.899 -61.579  -43.359 1.00 150.10 ? 426 ARG A O   1 
ATOM 3259 C CB  . ARG A 1 428 ? 76.516 -61.243  -45.529 1.00 156.09 ? 426 ARG A CB  1 
ATOM 3260 C CG  . ARG A 1 428 ? 76.879 -62.689  -45.851 1.00 156.92 ? 426 ARG A CG  1 
ATOM 3261 C CD  . ARG A 1 428 ? 77.887 -62.872  -47.008 1.00 158.13 ? 426 ARG A CD  1 
ATOM 3262 N NE  . ARG A 1 428 ? 77.799 -61.919  -48.126 1.00 156.81 ? 426 ARG A NE  1 
ATOM 3263 C CZ  . ARG A 1 428 ? 78.739 -61.048  -48.534 1.00 139.77 ? 426 ARG A CZ  1 
ATOM 3264 N NH1 . ARG A 1 428 ? 79.956 -61.036  -48.009 1.00 129.40 ? 426 ARG A NH1 1 
ATOM 3265 N NH2 . ARG A 1 428 ? 78.466 -60.187  -49.504 1.00 127.97 ? 426 ARG A NH2 1 
ATOM 3266 N N   . GLU A 1 429 ? 78.747 -59.385  -43.894 1.00 151.48 ? 427 GLU A N   1 
ATOM 3267 C CA  . GLU A 1 429 ? 80.143 -59.059  -43.618 1.00 143.45 ? 427 GLU A CA  1 
ATOM 3268 C C   . GLU A 1 429 ? 80.373 -58.997  -42.108 1.00 137.11 ? 427 GLU A C   1 
ATOM 3269 O O   . GLU A 1 429 ? 81.408 -59.464  -41.637 1.00 128.68 ? 427 GLU A O   1 
ATOM 3270 C CB  . GLU A 1 429 ? 80.532 -57.755  -44.330 1.00 144.46 ? 427 GLU A CB  1 
ATOM 3271 C CG  . GLU A 1 429 ? 81.948 -57.238  -44.070 1.00 139.28 ? 427 GLU A CG  1 
ATOM 3272 C CD  . GLU A 1 429 ? 82.351 -55.974  -44.821 1.00 141.98 ? 427 GLU A CD  1 
ATOM 3273 O OE1 . GLU A 1 429 ? 81.675 -54.909  -44.804 1.00 145.20 ? 427 GLU A OE1 1 
ATOM 3274 O OE2 . GLU A 1 429 ? 83.429 -56.069  -45.437 1.00 131.21 ? 427 GLU A OE2 1 
ATOM 3275 N N   . ALA A 1 430 ? 79.411 -58.422  -41.365 1.00 134.31 ? 428 ALA A N   1 
ATOM 3276 C CA  . ALA A 1 430 ? 79.535 -58.197  -39.929 1.00 116.19 ? 428 ALA A CA  1 
ATOM 3277 C C   . ALA A 1 430 ? 79.473 -59.519  -39.161 1.00 115.28 ? 428 ALA A C   1 
ATOM 3278 O O   . ALA A 1 430 ? 80.171 -59.654  -38.154 1.00 100.36 ? 428 ALA A O   1 
ATOM 3279 C CB  . ALA A 1 430 ? 78.463 -57.235  -39.450 1.00 111.99 ? 428 ALA A CB  1 
ATOM 3280 N N   . THR A 1 431 ? 78.632 -60.465  -39.634 1.00 118.09 ? 429 THR A N   1 
ATOM 3281 C CA  . THR A 1 431 ? 78.521 -61.803  -39.057 1.00 108.91 ? 429 THR A CA  1 
ATOM 3282 C C   . THR A 1 431 ? 79.862 -62.519  -39.216 1.00 110.95 ? 429 THR A C   1 
ATOM 3283 O O   . THR A 1 431 ? 80.408 -63.039  -38.254 1.00 120.72 ? 429 THR A O   1 
ATOM 3284 C CB  . THR A 1 431 ? 77.397 -62.659  -39.665 1.00 103.08 ? 429 THR A CB  1 
ATOM 3285 O OG1 . THR A 1 431 ? 77.713 -63.097  -40.980 1.00 95.53  ? 429 THR A OG1 1 
ATOM 3286 C CG2 . THR A 1 431 ? 76.056 -61.968  -39.800 1.00 107.54 ? 429 THR A CG2 1 
ATOM 3287 N N   . LEU A 1 432 ? 80.397 -62.527  -40.441 1.00 125.22 ? 430 LEU A N   1 
ATOM 3288 C CA  . LEU A 1 432 ? 81.652 -63.201  -40.740 1.00 118.51 ? 430 LEU A CA  1 
ATOM 3289 C C   . LEU A 1 432 ? 82.804 -62.530  -39.993 1.00 114.22 ? 430 LEU A C   1 
ATOM 3290 O O   . LEU A 1 432 ? 83.454 -63.192  -39.197 1.00 124.14 ? 430 LEU A O   1 
ATOM 3291 C CB  . LEU A 1 432 ? 81.909 -63.270  -42.247 1.00 119.65 ? 430 LEU A CB  1 
ATOM 3292 C CG  . LEU A 1 432 ? 80.949 -64.170  -43.037 1.00 117.64 ? 430 LEU A CG  1 
ATOM 3293 C CD1 . LEU A 1 432 ? 81.168 -64.111  -44.535 1.00 118.87 ? 430 LEU A CD1 1 
ATOM 3294 C CD2 . LEU A 1 432 ? 81.083 -65.605  -42.533 1.00 117.03 ? 430 LEU A CD2 1 
ATOM 3295 N N   . THR A 1 433 ? 83.053 -61.235  -40.225 1.00 118.76 ? 431 THR A N   1 
ATOM 3296 C CA  . THR A 1 433 ? 84.210 -60.565  -39.638 1.00 139.34 ? 431 THR A CA  1 
ATOM 3297 C C   . THR A 1 433 ? 84.026 -60.385  -38.125 1.00 138.68 ? 431 THR A C   1 
ATOM 3298 O O   . THR A 1 433 ? 85.009 -60.370  -37.378 1.00 129.86 ? 431 THR A O   1 
ATOM 3299 C CB  . THR A 1 433 ? 84.457 -59.222  -40.331 1.00 137.25 ? 431 THR A CB  1 
ATOM 3300 O OG1 . THR A 1 433 ? 83.246 -58.493  -40.160 1.00 142.19 ? 431 THR A OG1 1 
ATOM 3301 C CG2 . THR A 1 433 ? 84.800 -59.366  -41.804 1.00 127.05 ? 431 THR A CG2 1 
ATOM 3302 N N   . GLY A 1 434 ? 82.770 -60.220  -37.683 1.00 114.27 ? 432 GLY A N   1 
ATOM 3303 C CA  . GLY A 1 434 ? 82.458 -60.048  -36.275 1.00 108.41 ? 432 GLY A CA  1 
ATOM 3304 C C   . GLY A 1 434 ? 82.651 -58.607  -35.806 1.00 113.47 ? 432 GLY A C   1 
ATOM 3305 O O   . GLY A 1 434 ? 82.900 -58.374  -34.628 1.00 112.10 ? 432 GLY A O   1 
ATOM 3306 N N   . GLN A 1 435 ? 82.507 -57.639  -36.714 1.00 130.60 ? 433 GLN A N   1 
ATOM 3307 C CA  . GLN A 1 435 ? 82.725 -56.242  -36.371 1.00 144.28 ? 433 GLN A CA  1 
ATOM 3308 C C   . GLN A 1 435 ? 81.370 -55.575  -36.163 1.00 148.67 ? 433 GLN A C   1 
ATOM 3309 O O   . GLN A 1 435 ? 80.371 -56.039  -36.720 1.00 148.92 ? 433 GLN A O   1 
ATOM 3310 C CB  . GLN A 1 435 ? 83.523 -55.559  -37.477 1.00 151.32 ? 433 GLN A CB  1 
ATOM 3311 C CG  . GLN A 1 435 ? 84.852 -56.236  -37.785 1.00 152.27 ? 433 GLN A CG  1 
ATOM 3312 C CD  . GLN A 1 435 ? 85.453 -55.750  -39.086 1.00 149.52 ? 433 GLN A CD  1 
ATOM 3313 O OE1 . GLN A 1 435 ? 84.810 -55.791  -40.144 1.00 125.55 ? 433 GLN A OE1 1 
ATOM 3314 N NE2 . GLN A 1 435 ? 86.678 -55.245  -39.016 1.00 159.72 ? 433 GLN A NE2 1 
ATOM 3315 N N   . SER A 1 436 ? 81.353 -54.505  -35.347 1.00 137.98 ? 434 SER A N   1 
ATOM 3316 C CA  . SER A 1 436 ? 80.116 -53.821  -35.005 1.00 125.65 ? 434 SER A CA  1 
ATOM 3317 C C   . SER A 1 436 ? 79.529 -53.206  -36.272 1.00 126.16 ? 434 SER A C   1 
ATOM 3318 O O   . SER A 1 436 ? 80.264 -52.876  -37.194 1.00 121.86 ? 434 SER A O   1 
ATOM 3319 C CB  . SER A 1 436 ? 80.314 -52.790  -33.901 1.00 116.63 ? 434 SER A CB  1 
ATOM 3320 O OG  . SER A 1 436 ? 80.832 -51.554  -34.372 1.00 104.20 ? 434 SER A OG  1 
ATOM 3321 N N   . VAL A 1 437 ? 78.198 -53.099  -36.332 1.00 132.08 ? 435 VAL A N   1 
ATOM 3322 C CA  . VAL A 1 437 ? 77.542 -52.626  -37.540 1.00 136.81 ? 435 VAL A CA  1 
ATOM 3323 C C   . VAL A 1 437 ? 77.735 -51.109  -37.644 1.00 139.24 ? 435 VAL A C   1 
ATOM 3324 O O   . VAL A 1 437 ? 77.759 -50.573  -38.749 1.00 148.42 ? 435 VAL A O   1 
ATOM 3325 C CB  . VAL A 1 437 ? 76.064 -53.058  -37.624 1.00 143.61 ? 435 VAL A CB  1 
ATOM 3326 C CG1 . VAL A 1 437 ? 75.402 -52.590  -38.913 1.00 151.43 ? 435 VAL A CG1 1 
ATOM 3327 C CG2 . VAL A 1 437 ? 75.910 -54.572  -37.509 1.00 147.40 ? 435 VAL A CG2 1 
ATOM 3328 N N   . ARG A 1 438 ? 77.940 -50.421  -36.509 1.00 132.26 ? 436 ARG A N   1 
ATOM 3329 C CA  . ARG A 1 438 ? 78.235 -48.995  -36.516 1.00 132.61 ? 436 ARG A CA  1 
ATOM 3330 C C   . ARG A 1 438 ? 79.527 -48.734  -37.294 1.00 136.23 ? 436 ARG A C   1 
ATOM 3331 O O   . ARG A 1 438 ? 79.583 -47.821  -38.118 1.00 139.65 ? 436 ARG A O   1 
ATOM 3332 C CB  . ARG A 1 438 ? 78.353 -48.431  -35.094 1.00 138.11 ? 436 ARG A CB  1 
ATOM 3333 C CG  . ARG A 1 438 ? 78.656 -46.936  -35.062 1.00 136.36 ? 436 ARG A CG  1 
ATOM 3334 C CD  . ARG A 1 438 ? 78.950 -46.370  -33.683 1.00 122.76 ? 436 ARG A CD  1 
ATOM 3335 N NE  . ARG A 1 438 ? 77.910 -46.750  -32.720 1.00 131.54 ? 436 ARG A NE  1 
ATOM 3336 C CZ  . ARG A 1 438 ? 76.847 -46.025  -32.390 1.00 134.05 ? 436 ARG A CZ  1 
ATOM 3337 N NH1 . ARG A 1 438 ? 76.675 -44.807  -32.876 1.00 131.62 ? 436 ARG A NH1 1 
ATOM 3338 N NH2 . ARG A 1 438 ? 75.941 -46.536  -31.573 1.00 132.46 ? 436 ARG A NH2 1 
ATOM 3339 N N   . ASP A 1 439 ? 80.565 -49.540  -37.031 1.00 141.38 ? 437 ASP A N   1 
ATOM 3340 C CA  . ASP A 1 439 ? 81.887 -49.324  -37.608 1.00 132.70 ? 437 ASP A CA  1 
ATOM 3341 C C   . ASP A 1 439 ? 81.917 -49.745  -39.080 1.00 141.57 ? 437 ASP A C   1 
ATOM 3342 O O   . ASP A 1 439 ? 82.765 -49.262  -39.821 1.00 134.92 ? 437 ASP A O   1 
ATOM 3343 C CB  . ASP A 1 439 ? 82.967 -50.015  -36.788 1.00 117.54 ? 437 ASP A CB  1 
ATOM 3344 C CG  . ASP A 1 439 ? 83.070 -49.581  -35.332 1.00 101.69 ? 437 ASP A CG  1 
ATOM 3345 O OD1 . ASP A 1 439 ? 82.524 -48.516  -34.982 1.00 87.88  ? 437 ASP A OD1 1 
ATOM 3346 O OD2 . ASP A 1 439 ? 83.675 -50.332  -34.551 1.00 97.87  ? 437 ASP A OD2 1 
ATOM 3347 N N   . LEU A 1 440 ? 81.002 -50.643  -39.490 1.00 150.90 ? 438 LEU A N   1 
ATOM 3348 C CA  . LEU A 1 440 ? 80.832 -51.037  -40.886 1.00 142.08 ? 438 LEU A CA  1 
ATOM 3349 C C   . LEU A 1 440 ? 79.971 -50.027  -41.648 1.00 129.10 ? 438 LEU A C   1 
ATOM 3350 O O   . LEU A 1 440 ? 79.946 -50.055  -42.879 1.00 127.03 ? 438 LEU A O   1 
ATOM 3351 C CB  . LEU A 1 440 ? 80.217 -52.433  -41.003 1.00 142.38 ? 438 LEU A CB  1 
ATOM 3352 C CG  . LEU A 1 440 ? 81.184 -53.604  -41.179 1.00 135.84 ? 438 LEU A CG  1 
ATOM 3353 C CD1 . LEU A 1 440 ? 82.362 -53.541  -40.216 1.00 130.82 ? 438 LEU A CD1 1 
ATOM 3354 C CD2 . LEU A 1 440 ? 80.364 -54.882  -41.013 1.00 138.34 ? 438 LEU A CD2 1 
ATOM 3355 N N   . CYS A 1 441 ? 79.238 -49.172  -40.923 1.00 123.00 ? 439 CYS A N   1 
ATOM 3356 C CA  . CYS A 1 441 ? 78.468 -48.114  -41.552 1.00 129.14 ? 439 CYS A CA  1 
ATOM 3357 C C   . CYS A 1 441 ? 79.373 -46.924  -41.874 1.00 127.70 ? 439 CYS A C   1 
ATOM 3358 O O   . CYS A 1 441 ? 79.120 -46.235  -42.857 1.00 118.93 ? 439 CYS A O   1 
ATOM 3359 C CB  . CYS A 1 441 ? 77.254 -47.718  -40.716 1.00 135.39 ? 439 CYS A CB  1 
ATOM 3360 S SG  . CYS A 1 441 ? 75.755 -48.691  -41.030 1.00 139.23 ? 439 CYS A SG  1 
ATOM 3361 N N   . ARG A 1 442 ? 80.434 -46.685  -41.087 1.00 134.81 ? 440 ARG A N   1 
ATOM 3362 C CA  . ARG A 1 442 ? 81.325 -45.592  -41.443 1.00 138.83 ? 440 ARG A CA  1 
ATOM 3363 C C   . ARG A 1 442 ? 82.530 -46.110  -42.234 1.00 146.95 ? 440 ARG A C   1 
ATOM 3364 O O   . ARG A 1 442 ? 83.240 -45.312  -42.844 1.00 183.62 ? 440 ARG A O   1 
ATOM 3365 C CB  . ARG A 1 442 ? 81.681 -44.688  -40.262 1.00 128.89 ? 440 ARG A CB  1 
ATOM 3366 C CG  . ARG A 1 442 ? 81.440 -43.224  -40.626 1.00 121.46 ? 440 ARG A CG  1 
ATOM 3367 C CD  . ARG A 1 442 ? 81.343 -42.284  -39.449 1.00 122.69 ? 440 ARG A CD  1 
ATOM 3368 N NE  . ARG A 1 442 ? 80.409 -42.783  -38.434 1.00 133.28 ? 440 ARG A NE  1 
ATOM 3369 C CZ  . ARG A 1 442 ? 80.747 -43.047  -37.175 1.00 158.68 ? 440 ARG A CZ  1 
ATOM 3370 N NH1 . ARG A 1 442 ? 81.960 -42.743  -36.744 1.00 167.08 ? 440 ARG A NH1 1 
ATOM 3371 N NH2 . ARG A 1 442 ? 79.884 -43.596  -36.337 1.00 173.58 ? 440 ARG A NH2 1 
ATOM 3372 N N   . LYS A 1 443 ? 82.747 -47.428  -42.269 1.00 130.68 ? 441 LYS A N   1 
ATOM 3373 C CA  . LYS A 1 443 ? 83.780 -47.970  -43.144 1.00 119.16 ? 441 LYS A CA  1 
ATOM 3374 C C   . LYS A 1 443 ? 83.312 -47.761  -44.582 1.00 126.09 ? 441 LYS A C   1 
ATOM 3375 O O   . LYS A 1 443 ? 84.000 -47.117  -45.365 1.00 132.73 ? 441 LYS A O   1 
ATOM 3376 C CB  . LYS A 1 443 ? 84.076 -49.446  -42.856 1.00 115.87 ? 441 LYS A CB  1 
ATOM 3377 C CG  . LYS A 1 443 ? 84.719 -50.216  -44.000 1.00 115.56 ? 441 LYS A CG  1 
ATOM 3378 C CD  . LYS A 1 443 ? 83.874 -51.412  -44.430 1.00 121.29 ? 441 LYS A CD  1 
ATOM 3379 C CE  . LYS A 1 443 ? 84.407 -52.048  -45.657 1.00 120.40 ? 441 LYS A CE  1 
ATOM 3380 N NZ  . LYS A 1 443 ? 83.655 -53.254  -46.000 1.00 116.69 ? 441 LYS A NZ  1 
ATOM 3381 N N   . TYR A 1 444 ? 82.094 -48.235  -44.874 1.00 130.97 ? 442 TYR A N   1 
ATOM 3382 C CA  . TYR A 1 444 ? 81.425 -47.993  -46.146 1.00 131.18 ? 442 TYR A CA  1 
ATOM 3383 C C   . TYR A 1 444 ? 81.032 -46.511  -46.282 1.00 135.12 ? 442 TYR A C   1 
ATOM 3384 O O   . TYR A 1 444 ? 80.705 -46.059  -47.376 1.00 137.48 ? 442 TYR A O   1 
ATOM 3385 C CB  . TYR A 1 444 ? 80.145 -48.830  -46.285 1.00 137.00 ? 442 TYR A CB  1 
ATOM 3386 C CG  . TYR A 1 444 ? 80.096 -50.113  -47.114 1.00 148.17 ? 442 TYR A CG  1 
ATOM 3387 C CD1 . TYR A 1 444 ? 81.055 -51.117  -47.011 1.00 140.24 ? 442 TYR A CD1 1 
ATOM 3388 C CD2 . TYR A 1 444 ? 79.024 -50.330  -47.983 1.00 147.48 ? 442 TYR A CD2 1 
ATOM 3389 C CE1 . TYR A 1 444 ? 80.951 -52.285  -47.760 1.00 142.38 ? 442 TYR A CE1 1 
ATOM 3390 C CE2 . TYR A 1 444 ? 78.911 -51.488  -48.737 1.00 129.58 ? 442 TYR A CE2 1 
ATOM 3391 C CZ  . TYR A 1 444 ? 79.881 -52.470  -48.627 1.00 132.42 ? 442 TYR A CZ  1 
ATOM 3392 O OH  . TYR A 1 444 ? 79.755 -53.614  -49.368 1.00 93.23  ? 442 TYR A OH  1 
ATOM 3393 N N   . ASP A 1 445 ? 81.034 -45.768  -45.166 1.00 132.72 ? 443 ASP A N   1 
ATOM 3394 C CA  . ASP A 1 445 ? 80.607 -44.377  -45.106 1.00 131.15 ? 443 ASP A CA  1 
ATOM 3395 C C   . ASP A 1 445 ? 79.255 -44.206  -45.803 1.00 135.43 ? 443 ASP A C   1 
ATOM 3396 O O   . ASP A 1 445 ? 79.103 -43.339  -46.663 1.00 130.63 ? 443 ASP A O   1 
ATOM 3397 C CB  . ASP A 1 445 ? 81.696 -43.417  -45.566 1.00 124.56 ? 443 ASP A CB  1 
ATOM 3398 C CG  . ASP A 1 445 ? 81.456 -41.943  -45.245 1.00 128.09 ? 443 ASP A CG  1 
ATOM 3399 O OD1 . ASP A 1 445 ? 80.936 -41.636  -44.147 1.00 129.35 ? 443 ASP A OD1 1 
ATOM 3400 O OD2 . ASP A 1 445 ? 81.824 -41.093  -46.078 1.00 129.79 ? 443 ASP A OD2 1 
ATOM 3401 N N   . VAL A 1 446 ? 78.273 -45.016  -45.371 1.00 128.50 ? 444 VAL A N   1 
ATOM 3402 C CA  . VAL A 1 446 ? 76.889 -44.903  -45.806 1.00 116.63 ? 444 VAL A CA  1 
ATOM 3403 C C   . VAL A 1 446 ? 76.114 -43.976  -44.864 1.00 115.54 ? 444 VAL A C   1 
ATOM 3404 O O   . VAL A 1 446 ? 75.073 -43.440  -45.252 1.00 105.24 ? 444 VAL A O   1 
ATOM 3405 C CB  . VAL A 1 446 ? 76.241 -46.301  -45.860 1.00 108.32 ? 444 VAL A CB  1 
ATOM 3406 C CG1 . VAL A 1 446 ? 74.826 -46.259  -46.435 1.00 115.49 ? 444 VAL A CG1 1 
ATOM 3407 C CG2 . VAL A 1 446 ? 77.091 -47.295  -46.633 1.00 97.42  ? 444 VAL A CG2 1 
ATOM 3408 N N   . LEU A 1 447 ? 76.608 -43.809  -43.622 1.00 110.15 ? 445 LEU A N   1 
ATOM 3409 C CA  . LEU A 1 447 ? 75.922 -43.010  -42.619 1.00 116.93 ? 445 LEU A CA  1 
ATOM 3410 C C   . LEU A 1 447 ? 76.928 -42.221  -41.774 1.00 121.95 ? 445 LEU A C   1 
ATOM 3411 O O   . LEU A 1 447 ? 78.011 -42.715  -41.478 1.00 109.86 ? 445 LEU A O   1 
ATOM 3412 C CB  . LEU A 1 447 ? 75.057 -43.930  -41.753 1.00 133.13 ? 445 LEU A CB  1 
ATOM 3413 C CG  . LEU A 1 447 ? 73.741 -44.438  -42.360 1.00 130.19 ? 445 LEU A CG  1 
ATOM 3414 C CD1 . LEU A 1 447 ? 73.116 -45.524  -41.488 1.00 111.20 ? 445 LEU A CD1 1 
ATOM 3415 C CD2 . LEU A 1 447 ? 72.758 -43.299  -42.576 1.00 125.54 ? 445 LEU A CD2 1 
ATOM 3416 N N   . SER A 1 448 ? 76.541 -40.999  -41.363 1.00 129.05 ? 446 SER A N   1 
ATOM 3417 C CA  . SER A 1 448 ? 77.357 -40.151  -40.501 1.00 122.99 ? 446 SER A CA  1 
ATOM 3418 C C   . SER A 1 448 ? 77.333 -40.652  -39.056 1.00 135.50 ? 446 SER A C   1 
ATOM 3419 O O   . SER A 1 448 ? 76.391 -41.329  -38.656 1.00 152.64 ? 446 SER A O   1 
ATOM 3420 C CB  . SER A 1 448 ? 76.886 -38.721  -40.559 1.00 114.96 ? 446 SER A CB  1 
ATOM 3421 O OG  . SER A 1 448 ? 77.342 -37.982  -39.435 1.00 141.24 ? 446 SER A OG  1 
ATOM 3422 N N   . ASP A 1 449 ? 78.355 -40.270  -38.272 1.00 140.90 ? 447 ASP A N   1 
ATOM 3423 C CA  . ASP A 1 449 ? 78.455 -40.646  -36.866 1.00 144.92 ? 447 ASP A CA  1 
ATOM 3424 C C   . ASP A 1 449 ? 77.286 -40.072  -36.061 1.00 132.38 ? 447 ASP A C   1 
ATOM 3425 O O   . ASP A 1 449 ? 76.680 -40.763  -35.235 1.00 112.33 ? 447 ASP A O   1 
ATOM 3426 C CB  . ASP A 1 449 ? 79.754 -40.158  -36.241 1.00 145.33 ? 447 ASP A CB  1 
ATOM 3427 C CG  . ASP A 1 449 ? 80.012 -40.571  -34.794 1.00 154.86 ? 447 ASP A CG  1 
ATOM 3428 O OD1 . ASP A 1 449 ? 79.183 -41.297  -34.195 1.00 172.21 ? 447 ASP A OD1 1 
ATOM 3429 O OD2 . ASP A 1 449 ? 81.054 -40.157  -34.257 1.00 152.92 ? 447 ASP A OD2 1 
ATOM 3430 N N   . GLU A 1 450 ? 76.968 -38.799  -36.315 1.00 132.12 ? 448 GLU A N   1 
ATOM 3431 C CA  . GLU A 1 450 ? 75.867 -38.146  -35.623 1.00 129.15 ? 448 GLU A CA  1 
ATOM 3432 C C   . GLU A 1 450 ? 74.574 -38.898  -35.935 1.00 140.21 ? 448 GLU A C   1 
ATOM 3433 O O   . GLU A 1 450 ? 73.760 -39.132  -35.038 1.00 149.28 ? 448 GLU A O   1 
ATOM 3434 C CB  . GLU A 1 450 ? 75.693 -36.689  -36.047 1.00 134.68 ? 448 GLU A CB  1 
ATOM 3435 C CG  . GLU A 1 450 ? 76.878 -35.779  -35.728 1.00 139.62 ? 448 GLU A CG  1 
ATOM 3436 C CD  . GLU A 1 450 ? 78.079 -35.869  -36.658 1.00 136.67 ? 448 GLU A CD  1 
ATOM 3437 O OE1 . GLU A 1 450 ? 79.190 -36.187  -36.185 1.00 129.78 ? 448 GLU A OE1 1 
ATOM 3438 O OE2 . GLU A 1 450 ? 77.896 -35.643  -37.867 1.00 132.58 ? 448 GLU A OE2 1 
ATOM 3439 N N   . GLU A 1 451 ? 74.420 -39.290  -37.213 1.00 150.01 ? 449 GLU A N   1 
ATOM 3440 C CA  . GLU A 1 451 ? 73.247 -40.028  -37.664 1.00 128.77 ? 449 GLU A CA  1 
ATOM 3441 C C   . GLU A 1 451 ? 73.171 -41.356  -36.914 1.00 126.64 ? 449 GLU A C   1 
ATOM 3442 O O   . GLU A 1 451 ? 72.101 -41.755  -36.453 1.00 143.64 ? 449 GLU A O   1 
ATOM 3443 C CB  . GLU A 1 451 ? 73.269 -40.311  -39.168 1.00 115.11 ? 449 GLU A CB  1 
ATOM 3444 C CG  . GLU A 1 451 ? 73.306 -39.061  -40.041 1.00 103.52 ? 449 GLU A CG  1 
ATOM 3445 C CD  . GLU A 1 451 ? 73.210 -39.350  -41.529 1.00 103.72 ? 449 GLU A CD  1 
ATOM 3446 O OE1 . GLU A 1 451 ? 74.064 -40.086  -42.054 1.00 114.53 ? 449 GLU A OE1 1 
ATOM 3447 O OE2 . GLU A 1 451 ? 72.279 -38.842  -42.179 1.00 101.21 ? 449 GLU A OE2 1 
ATOM 3448 N N   . LEU A 1 452 ? 74.322 -42.019  -36.754 1.00 123.61 ? 450 LEU A N   1 
ATOM 3449 C CA  . LEU A 1 452 ? 74.337 -43.329  -36.123 1.00 121.99 ? 450 LEU A CA  1 
ATOM 3450 C C   . LEU A 1 452 ? 74.001 -43.213  -34.634 1.00 112.34 ? 450 LEU A C   1 
ATOM 3451 O O   . LEU A 1 452 ? 73.412 -44.128  -34.075 1.00 97.13  ? 450 LEU A O   1 
ATOM 3452 C CB  . LEU A 1 452 ? 75.663 -44.045  -36.375 1.00 127.18 ? 450 LEU A CB  1 
ATOM 3453 C CG  . LEU A 1 452 ? 75.852 -44.586  -37.797 1.00 128.35 ? 450 LEU A CG  1 
ATOM 3454 C CD1 . LEU A 1 452 ? 77.321 -44.797  -38.156 1.00 131.18 ? 450 LEU A CD1 1 
ATOM 3455 C CD2 . LEU A 1 452 ? 75.059 -45.876  -37.998 1.00 130.22 ? 450 LEU A CD2 1 
ATOM 3456 N N   . ASP A 1 453 ? 74.352 -42.080  -34.010 1.00 117.23 ? 451 ASP A N   1 
ATOM 3457 C CA  . ASP A 1 453 ? 73.937 -41.790  -32.644 1.00 120.94 ? 451 ASP A CA  1 
ATOM 3458 C C   . ASP A 1 453 ? 72.413 -41.840  -32.527 1.00 130.40 ? 451 ASP A C   1 
ATOM 3459 O O   . ASP A 1 453 ? 71.887 -42.314  -31.517 1.00 139.16 ? 451 ASP A O   1 
ATOM 3460 C CB  . ASP A 1 453 ? 74.416 -40.430  -32.162 1.00 117.62 ? 451 ASP A CB  1 
ATOM 3461 C CG  . ASP A 1 453 ? 75.923 -40.243  -32.147 1.00 112.37 ? 451 ASP A CG  1 
ATOM 3462 O OD1 . ASP A 1 453 ? 76.618 -41.174  -31.692 1.00 103.80 ? 451 ASP A OD1 1 
ATOM 3463 O OD2 . ASP A 1 453 ? 76.373 -39.172  -32.589 1.00 116.95 ? 451 ASP A OD2 1 
ATOM 3464 N N   . LEU A 1 454 ? 71.712 -41.317  -33.546 1.00 137.07 ? 452 LEU A N   1 
ATOM 3465 C CA  . LEU A 1 454 ? 70.264 -41.137  -33.492 1.00 123.85 ? 452 LEU A CA  1 
ATOM 3466 C C   . LEU A 1 454 ? 69.546 -42.437  -33.869 1.00 116.04 ? 452 LEU A C   1 
ATOM 3467 O O   . LEU A 1 454 ? 68.551 -42.779  -33.236 1.00 106.32 ? 452 LEU A O   1 
ATOM 3468 C CB  . LEU A 1 454 ? 69.858 -39.954  -34.375 1.00 126.22 ? 452 LEU A CB  1 
ATOM 3469 C CG  . LEU A 1 454 ? 70.521 -38.606  -34.043 1.00 136.96 ? 452 LEU A CG  1 
ATOM 3470 C CD1 . LEU A 1 454 ? 70.229 -37.540  -35.098 1.00 128.82 ? 452 LEU A CD1 1 
ATOM 3471 C CD2 . LEU A 1 454 ? 70.135 -38.081  -32.658 1.00 130.80 ? 452 LEU A CD2 1 
ATOM 3472 N N   . ILE A 1 455 ? 70.101 -43.200  -34.829 1.00 123.49 ? 453 ILE A N   1 
ATOM 3473 C CA  . ILE A 1 455 ? 69.515 -44.464  -35.274 1.00 119.37 ? 453 ILE A CA  1 
ATOM 3474 C C   . ILE A 1 455 ? 69.763 -45.567  -34.237 1.00 110.65 ? 453 ILE A C   1 
ATOM 3475 O O   . ILE A 1 455 ? 68.854 -46.343  -33.947 1.00 108.50 ? 453 ILE A O   1 
ATOM 3476 C CB  . ILE A 1 455 ? 70.033 -44.874  -36.673 1.00 125.87 ? 453 ILE A CB  1 
ATOM 3477 C CG1 . ILE A 1 455 ? 69.763 -43.788  -37.748 1.00 116.36 ? 453 ILE A CG1 1 
ATOM 3478 C CG2 . ILE A 1 455 ? 69.469 -46.235  -37.102 1.00 124.17 ? 453 ILE A CG2 1 
ATOM 3479 C CD1 . ILE A 1 455 ? 70.644 -43.889  -38.982 1.00 109.21 ? 453 ILE A CD1 1 
ATOM 3480 N N   . LEU A 1 456 ? 70.980 -45.633  -33.673 1.00 114.61 ? 454 LEU A N   1 
ATOM 3481 C CA  . LEU A 1 456 ? 71.311 -46.623  -32.647 1.00 113.89 ? 454 LEU A CA  1 
ATOM 3482 C C   . LEU A 1 456 ? 71.117 -46.028  -31.247 1.00 107.82 ? 454 LEU A C   1 
ATOM 3483 O O   . LEU A 1 456 ? 71.851 -46.371  -30.315 1.00 101.62 ? 454 LEU A O   1 
ATOM 3484 C CB  . LEU A 1 456 ? 72.730 -47.182  -32.796 1.00 112.29 ? 454 LEU A CB  1 
ATOM 3485 C CG  . LEU A 1 456 ? 73.127 -47.729  -34.169 1.00 116.49 ? 454 LEU A CG  1 
ATOM 3486 C CD1 . LEU A 1 456 ? 74.546 -48.273  -34.115 1.00 111.43 ? 454 LEU A CD1 1 
ATOM 3487 C CD2 . LEU A 1 456 ? 72.147 -48.786  -34.652 1.00 123.31 ? 454 LEU A CD2 1 
ATOM 3488 N N   . ASP A 1 457 ? 70.101 -45.164  -31.104 1.00 103.22 ? 455 ASP A N   1 
ATOM 3489 C CA  . ASP A 1 457 ? 69.673 -44.631  -29.826 1.00 114.07 ? 455 ASP A CA  1 
ATOM 3490 C C   . ASP A 1 457 ? 68.899 -45.736  -29.103 1.00 115.23 ? 455 ASP A C   1 
ATOM 3491 O O   . ASP A 1 457 ? 67.993 -46.341  -29.687 1.00 101.73 ? 455 ASP A O   1 
ATOM 3492 C CB  . ASP A 1 457 ? 68.912 -43.326  -30.043 1.00 116.84 ? 455 ASP A CB  1 
ATOM 3493 C CG  . ASP A 1 457 ? 68.236 -42.708  -28.823 1.00 117.74 ? 455 ASP A CG  1 
ATOM 3494 O OD1 . ASP A 1 457 ? 67.096 -43.110  -28.518 1.00 125.64 ? 455 ASP A OD1 1 
ATOM 3495 O OD2 . ASP A 1 457 ? 68.853 -41.835  -28.172 1.00 106.35 ? 455 ASP A OD2 1 
ATOM 3496 N N   . PRO A 1 458 ? 69.231 -46.044  -27.822 1.00 110.78 ? 456 PRO A N   1 
ATOM 3497 C CA  . PRO A 1 458 ? 68.382 -46.904  -26.992 1.00 107.02 ? 456 PRO A CA  1 
ATOM 3498 C C   . PRO A 1 458 ? 66.865 -46.736  -27.148 1.00 115.28 ? 456 PRO A C   1 
ATOM 3499 O O   . PRO A 1 458 ? 66.131 -47.722  -27.179 1.00 115.04 ? 456 PRO A O   1 
ATOM 3500 C CB  . PRO A 1 458 ? 68.865 -46.531  -25.572 1.00 100.16 ? 456 PRO A CB  1 
ATOM 3501 C CG  . PRO A 1 458 ? 70.330 -46.195  -25.736 1.00 97.86  ? 456 PRO A CG  1 
ATOM 3502 C CD  . PRO A 1 458 ? 70.469 -45.633  -27.135 1.00 101.55 ? 456 PRO A CD  1 
ATOM 3503 N N   . TYR A 1 459 ? 66.394 -45.486  -27.251 1.00 124.06 ? 457 TYR A N   1 
ATOM 3504 C CA  . TYR A 1 459 ? 64.971 -45.199  -27.334 1.00 127.18 ? 457 TYR A CA  1 
ATOM 3505 C C   . TYR A 1 459 ? 64.464 -45.452  -28.755 1.00 120.92 ? 457 TYR A C   1 
ATOM 3506 O O   . TYR A 1 459 ? 63.326 -45.890  -28.894 1.00 138.86 ? 457 TYR A O   1 
ATOM 3507 C CB  . TYR A 1 459 ? 64.698 -43.802  -26.745 1.00 145.23 ? 457 TYR A CB  1 
ATOM 3508 C CG  . TYR A 1 459 ? 63.537 -42.972  -27.300 1.00 181.40 ? 457 TYR A CG  1 
ATOM 3509 C CD1 . TYR A 1 459 ? 62.208 -43.355  -27.122 1.00 191.46 ? 457 TYR A CD1 1 
ATOM 3510 C CD2 . TYR A 1 459 ? 63.773 -41.756  -27.946 1.00 177.38 ? 457 TYR A CD2 1 
ATOM 3511 C CE1 . TYR A 1 459 ? 61.160 -42.591  -27.614 1.00 182.89 ? 457 TYR A CE1 1 
ATOM 3512 C CE2 . TYR A 1 459 ? 62.734 -40.979  -28.434 1.00 170.63 ? 457 TYR A CE2 1 
ATOM 3513 C CZ  . TYR A 1 459 ? 61.424 -41.397  -28.264 1.00 173.77 ? 457 TYR A CZ  1 
ATOM 3514 O OH  . TYR A 1 459 ? 60.400 -40.637  -28.742 1.00 158.25 ? 457 TYR A OH  1 
ATOM 3515 N N   . GLU A 1 460 ? 65.292 -45.219  -29.791 1.00 110.42 ? 458 GLU A N   1 
ATOM 3516 C CA  . GLU A 1 460 ? 64.809 -45.162  -31.169 1.00 104.16 ? 458 GLU A CA  1 
ATOM 3517 C C   . GLU A 1 460 ? 64.670 -46.568  -31.756 1.00 92.20  ? 458 GLU A C   1 
ATOM 3518 O O   . GLU A 1 460 ? 63.737 -46.845  -32.512 1.00 83.03  ? 458 GLU A O   1 
ATOM 3519 C CB  . GLU A 1 460 ? 65.717 -44.306  -32.059 1.00 110.17 ? 458 GLU A CB  1 
ATOM 3520 C CG  . GLU A 1 460 ? 65.663 -42.808  -31.753 1.00 107.41 ? 458 GLU A CG  1 
ATOM 3521 C CD  . GLU A 1 460 ? 64.420 -42.072  -32.237 1.00 100.55 ? 458 GLU A CD  1 
ATOM 3522 O OE1 . GLU A 1 460 ? 63.870 -41.241  -31.472 1.00 94.69  ? 458 GLU A OE1 1 
ATOM 3523 O OE2 . GLU A 1 460 ? 64.000 -42.338  -33.388 1.00 88.46  ? 458 GLU A OE2 1 
ATOM 3524 N N   . MET A 1 461 ? 65.599 -47.450  -31.379 1.00 91.97  ? 459 MET A N   1 
ATOM 3525 C CA  . MET A 1 461 ? 65.578 -48.824  -31.843 1.00 98.65  ? 459 MET A CA  1 
ATOM 3526 C C   . MET A 1 461 ? 64.395 -49.598  -31.246 1.00 107.90 ? 459 MET A C   1 
ATOM 3527 O O   . MET A 1 461 ? 64.110 -50.702  -31.709 1.00 122.64 ? 459 MET A O   1 
ATOM 3528 C CB  . MET A 1 461 ? 66.910 -49.501  -31.500 1.00 93.86  ? 459 MET A CB  1 
ATOM 3529 C CG  . MET A 1 461 ? 68.113 -48.828  -32.138 1.00 92.71  ? 459 MET A CG  1 
ATOM 3530 S SD  . MET A 1 461 ? 69.699 -49.602  -31.754 1.00 85.16  ? 459 MET A SD  1 
ATOM 3531 C CE  . MET A 1 461 ? 69.823 -49.283  -29.990 1.00 87.69  ? 459 MET A CE  1 
ATOM 3532 N N   . THR A 1 462 ? 63.698 -49.031  -30.239 1.00 98.03  ? 460 THR A N   1 
ATOM 3533 C CA  . THR A 1 462 ? 62.735 -49.780  -29.440 1.00 86.04  ? 460 THR A CA  1 
ATOM 3534 C C   . THR A 1 462 ? 61.380 -49.064  -29.349 1.00 85.34  ? 460 THR A C   1 
ATOM 3535 O O   . THR A 1 462 ? 60.653 -49.254  -28.378 1.00 84.08  ? 460 THR A O   1 
ATOM 3536 C CB  . THR A 1 462 ? 63.274 -50.081  -28.031 1.00 82.60  ? 460 THR A CB  1 
ATOM 3537 O OG1 . THR A 1 462 ? 63.347 -48.903  -27.237 1.00 75.44  ? 460 THR A OG1 1 
ATOM 3538 C CG2 . THR A 1 462 ? 64.664 -50.686  -28.028 1.00 86.99  ? 460 THR A CG2 1 
ATOM 3539 N N   . HIS A 1 463 ? 61.005 -48.259  -30.346 1.00 83.36  ? 461 HIS A N   1 
ATOM 3540 C CA  . HIS A 1 463 ? 59.645 -47.742  -30.399 1.00 85.53  ? 461 HIS A CA  1 
ATOM 3541 C C   . HIS A 1 463 ? 59.084 -48.105  -31.769 1.00 97.15  ? 461 HIS A C   1 
ATOM 3542 O O   . HIS A 1 463 ? 59.851 -48.472  -32.661 1.00 107.39 ? 461 HIS A O   1 
ATOM 3543 C CB  . HIS A 1 463 ? 59.589 -46.249  -30.039 1.00 96.58  ? 461 HIS A CB  1 
ATOM 3544 C CG  . HIS A 1 463 ? 60.058 -45.316  -31.111 1.00 115.44 ? 461 HIS A CG  1 
ATOM 3545 N ND1 . HIS A 1 463 ? 61.309 -45.388  -31.685 1.00 130.86 ? 461 HIS A ND1 1 
ATOM 3546 C CD2 . HIS A 1 463 ? 59.433 -44.291  -31.708 1.00 121.92 ? 461 HIS A CD2 1 
ATOM 3547 C CE1 . HIS A 1 463 ? 61.426 -44.436  -32.600 1.00 133.49 ? 461 HIS A CE1 1 
ATOM 3548 N NE2 . HIS A 1 463 ? 60.297 -43.753  -32.628 1.00 126.06 ? 461 HIS A NE2 1 
ATOM 3549 N N   . PRO A 1 464 ? 57.743 -48.092  -31.969 1.00 102.04 ? 462 PRO A N   1 
ATOM 3550 C CA  . PRO A 1 464 ? 57.168 -48.207  -33.309 1.00 102.88 ? 462 PRO A CA  1 
ATOM 3551 C C   . PRO A 1 464 ? 57.596 -47.003  -34.145 1.00 114.90 ? 462 PRO A C   1 
ATOM 3552 O O   . PRO A 1 464 ? 57.602 -45.873  -33.656 1.00 117.80 ? 462 PRO A O   1 
ATOM 3553 C CB  . PRO A 1 464 ? 55.644 -48.289  -33.114 1.00 91.42  ? 462 PRO A CB  1 
ATOM 3554 C CG  . PRO A 1 464 ? 55.463 -48.529  -31.635 1.00 91.06  ? 462 PRO A CG  1 
ATOM 3555 C CD  . PRO A 1 464 ? 56.708 -47.993  -30.931 1.00 97.04  ? 462 PRO A CD  1 
ATOM 3556 N N   . GLY A 1 465 ? 57.945 -47.274  -35.410 1.00 123.23 ? 463 GLY A N   1 
ATOM 3557 C CA  . GLY A 1 465 ? 58.582 -46.302  -36.281 1.00 131.86 ? 463 GLY A CA  1 
ATOM 3558 C C   . GLY A 1 465 ? 59.871 -46.878  -36.854 1.00 126.19 ? 463 GLY A C   1 
ATOM 3559 O O   . GLY A 1 465 ? 60.118 -48.073  -36.725 1.00 119.98 ? 463 GLY A O   1 
ATOM 3560 N N   . ILE A 1 466 ? 60.697 -46.011  -37.450 1.00 117.00 ? 464 ILE A N   1 
ATOM 3561 C CA  . ILE A 1 466 ? 61.714 -46.450  -38.390 1.00 103.16 ? 464 ILE A CA  1 
ATOM 3562 C C   . ILE A 1 466 ? 63.109 -46.015  -37.930 1.00 106.15 ? 464 ILE A C   1 
ATOM 3563 O O   . ILE A 1 466 ? 64.066 -46.181  -38.680 1.00 103.73 ? 464 ILE A O   1 
ATOM 3564 C CB  . ILE A 1 466 ? 61.365 -45.907  -39.789 1.00 94.24  ? 464 ILE A CB  1 
ATOM 3565 C CG1 . ILE A 1 466 ? 59.849 -45.803  -40.041 1.00 105.07 ? 464 ILE A CG1 1 
ATOM 3566 C CG2 . ILE A 1 466 ? 62.037 -46.730  -40.873 1.00 86.05  ? 464 ILE A CG2 1 
ATOM 3567 C CD1 . ILE A 1 466 ? 59.142 -47.128  -40.278 1.00 107.50 ? 464 ILE A CD1 1 
ATOM 3568 N N   . ALA A 1 467 ? 63.207 -45.467  -36.702 1.00 112.97 ? 465 ALA A N   1 
ATOM 3569 C CA  . ALA A 1 467 ? 64.450 -45.020  -36.070 1.00 111.94 ? 465 ALA A CA  1 
ATOM 3570 C C   . ALA A 1 467 ? 65.096 -43.819  -36.781 1.00 126.75 ? 465 ALA A C   1 
ATOM 3571 O O   . ALA A 1 467 ? 66.328 -43.737  -36.831 1.00 121.14 ? 465 ALA A O   1 
ATOM 3572 C CB  . ALA A 1 467 ? 65.414 -46.183  -35.952 1.00 100.88 ? 465 ALA A CB  1 
ATOM 3573 N N   . GLY A 1 468 ? 64.264 -42.863  -37.255 1.00 136.05 ? 466 GLY A N   1 
ATOM 3574 C CA  . GLY A 1 468 ? 64.693 -41.708  -38.040 1.00 108.76 ? 466 GLY A CA  1 
ATOM 3575 C C   . GLY A 1 468 ? 63.740 -40.527  -37.825 1.00 85.58  ? 466 GLY A C   1 
ATOM 3576 O O   . GLY A 1 468 ? 63.218 -40.044  -38.849 1.00 71.14  ? 466 GLY A O   1 
ATOM 3577 N N   . TYR B 1 7   ? 71.887 -66.544  24.705  1.00 102.47 ? 5   TYR B N   1 
ATOM 3578 C CA  . TYR B 1 7   ? 71.750 -66.378  23.233  1.00 99.29  ? 5   TYR B CA  1 
ATOM 3579 C C   . TYR B 1 7   ? 73.133 -66.395  22.594  1.00 101.32 ? 5   TYR B C   1 
ATOM 3580 O O   . TYR B 1 7   ? 74.078 -65.810  23.165  1.00 118.76 ? 5   TYR B O   1 
ATOM 3581 C CB  . TYR B 1 7   ? 71.029 -65.069  22.905  1.00 30.00  ? 5   TYR B CB  1 
ATOM 3582 C CG  . TYR B 1 7   ? 69.834 -65.223  21.976  1.00 30.00  ? 5   TYR B CG  1 
ATOM 3583 C CD1 . TYR B 1 7   ? 68.639 -65.767  22.430  1.00 30.00  ? 5   TYR B CD1 1 
ATOM 3584 C CD2 . TYR B 1 7   ? 69.900 -64.819  20.649  1.00 30.00  ? 5   TYR B CD2 1 
ATOM 3585 C CE1 . TYR B 1 7   ? 67.545 -65.905  21.593  1.00 30.00  ? 5   TYR B CE1 1 
ATOM 3586 C CE2 . TYR B 1 7   ? 68.813 -64.954  19.801  1.00 30.00  ? 5   TYR B CE2 1 
ATOM 3587 C CZ  . TYR B 1 7   ? 67.634 -65.498  20.274  1.00 30.00  ? 5   TYR B CZ  1 
ATOM 3588 O OH  . TYR B 1 7   ? 66.561 -65.631  19.441  1.00 30.00  ? 5   TYR B OH  1 
ATOM 3589 N N   . ARG B 1 8   ? 73.253 -67.042  21.433  1.00 101.14 ? 6   ARG B N   1 
ATOM 3590 C CA  . ARG B 1 8   ? 74.535 -67.092  20.724  1.00 105.16 ? 6   ARG B CA  1 
ATOM 3591 C C   . ARG B 1 8   ? 74.617 -65.964  19.680  1.00 103.71 ? 6   ARG B C   1 
ATOM 3592 O O   . ARG B 1 8   ? 73.666 -65.203  19.492  1.00 106.68 ? 6   ARG B O   1 
ATOM 3593 C CB  . ARG B 1 8   ? 74.731 -68.475  20.078  1.00 108.43 ? 6   ARG B CB  1 
ATOM 3594 C CG  . ARG B 1 8   ? 76.020 -68.705  19.288  1.00 113.40 ? 6   ARG B CG  1 
ATOM 3595 C CD  . ARG B 1 8   ? 76.033 -69.965  18.416  1.00 110.45 ? 6   ARG B CD  1 
ATOM 3596 N NE  . ARG B 1 8   ? 75.346 -71.074  19.091  1.00 114.15 ? 6   ARG B NE  1 
ATOM 3597 C CZ  . ARG B 1 8   ? 74.428 -71.906  18.592  1.00 103.98 ? 6   ARG B CZ  1 
ATOM 3598 N NH1 . ARG B 1 8   ? 74.353 -72.165  17.299  1.00 94.39  ? 6   ARG B NH1 1 
ATOM 3599 N NH2 . ARG B 1 8   ? 73.636 -72.551  19.429  1.00 109.11 ? 6   ARG B NH2 1 
ATOM 3600 N N   . ILE B 1 9   ? 75.807 -65.801  19.075  1.00 94.79  ? 7   ILE B N   1 
ATOM 3601 C CA  . ILE B 1 9   ? 76.009 -64.961  17.901  1.00 90.09  ? 7   ILE B CA  1 
ATOM 3602 C C   . ILE B 1 9   ? 76.958 -65.659  16.925  1.00 84.51  ? 7   ILE B C   1 
ATOM 3603 O O   . ILE B 1 9   ? 77.951 -66.233  17.360  1.00 79.47  ? 7   ILE B O   1 
ATOM 3604 C CB  . ILE B 1 9   ? 76.535 -63.579  18.334  1.00 96.38  ? 7   ILE B CB  1 
ATOM 3605 C CG1 . ILE B 1 9   ? 75.390 -62.732  18.958  1.00 97.53  ? 7   ILE B CG1 1 
ATOM 3606 C CG2 . ILE B 1 9   ? 77.250 -62.871  17.174  1.00 93.38  ? 7   ILE B CG2 1 
ATOM 3607 C CD1 . ILE B 1 9   ? 75.765 -61.310  19.344  1.00 96.43  ? 7   ILE B CD1 1 
ATOM 3608 N N   . GLU B 1 10  ? 76.634 -65.609  15.616  1.00 100.90 ? 8   GLU B N   1 
ATOM 3609 C CA  . GLU B 1 10  ? 77.400 -66.254  14.541  1.00 107.76 ? 8   GLU B CA  1 
ATOM 3610 C C   . GLU B 1 10  ? 77.493 -65.287  13.357  1.00 104.14 ? 8   GLU B C   1 
ATOM 3611 O O   . GLU B 1 10  ? 76.740 -64.311  13.316  1.00 103.40 ? 8   GLU B O   1 
ATOM 3612 C CB  . GLU B 1 10  ? 76.828 -67.574  13.989  1.00 98.87  ? 8   GLU B CB  1 
ATOM 3613 C CG  . GLU B 1 10  ? 76.529 -68.658  15.026  1.00 93.69  ? 8   GLU B CG  1 
ATOM 3614 C CD  . GLU B 1 10  ? 76.293 -70.049  14.484  1.00 94.97  ? 8   GLU B CD  1 
ATOM 3615 O OE1 . GLU B 1 10  ? 76.609 -70.315  13.300  1.00 105.50 ? 8   GLU B OE1 1 
ATOM 3616 O OE2 . GLU B 1 10  ? 75.810 -70.885  15.274  1.00 91.05  ? 8   GLU B OE2 1 
ATOM 3617 N N   . LYS B 1 11  ? 78.372 -65.561  12.375  1.00 92.63  ? 9   LYS B N   1 
ATOM 3618 C CA  . LYS B 1 11  ? 78.541 -64.616  11.278  1.00 99.29  ? 9   LYS B CA  1 
ATOM 3619 C C   . LYS B 1 11  ? 78.820 -65.319  9.949   1.00 108.24 ? 9   LYS B C   1 
ATOM 3620 O O   . LYS B 1 11  ? 79.326 -66.434  9.934   1.00 112.65 ? 9   LYS B O   1 
ATOM 3621 C CB  . LYS B 1 11  ? 79.643 -63.624  11.661  1.00 110.04 ? 9   LYS B CB  1 
ATOM 3622 C CG  . LYS B 1 11  ? 79.567 -62.278  10.945  1.00 125.88 ? 9   LYS B CG  1 
ATOM 3623 C CD  . LYS B 1 11  ? 79.925 -61.102  11.849  1.00 126.98 ? 9   LYS B CD  1 
ATOM 3624 C CE  . LYS B 1 11  ? 79.635 -59.770  11.232  1.00 130.70 ? 9   LYS B CE  1 
ATOM 3625 N NZ  . LYS B 1 11  ? 79.794 -58.712  12.233  1.00 132.18 ? 9   LYS B NZ  1 
ATOM 3626 N N   . ASP B 1 12  ? 78.490 -64.643  8.835   1.00 123.88 ? 10  ASP B N   1 
ATOM 3627 C CA  . ASP B 1 12  ? 78.650 -65.155  7.472   1.00 130.77 ? 10  ASP B CA  1 
ATOM 3628 C C   . ASP B 1 12  ? 78.803 -63.934  6.558   1.00 132.18 ? 10  ASP B C   1 
ATOM 3629 O O   . ASP B 1 12  ? 78.686 -62.802  7.060   1.00 128.19 ? 10  ASP B O   1 
ATOM 3630 C CB  . ASP B 1 12  ? 77.527 -66.126  7.103   1.00 137.77 ? 10  ASP B CB  1 
ATOM 3631 C CG  . ASP B 1 12  ? 76.127 -65.537  6.913   1.00 153.20 ? 10  ASP B CG  1 
ATOM 3632 O OD1 . ASP B 1 12  ? 75.976 -64.302  7.036   1.00 188.60 ? 10  ASP B OD1 1 
ATOM 3633 O OD2 . ASP B 1 12  ? 75.189 -66.324  6.657   1.00 155.45 ? 10  ASP B OD2 1 
ATOM 3634 N N   . PHE B 1 13  ? 79.043 -64.148  5.242   1.00 123.36 ? 11  PHE B N   1 
ATOM 3635 C CA  . PHE B 1 13  ? 79.227 -63.035  4.313   1.00 106.78 ? 11  PHE B CA  1 
ATOM 3636 C C   . PHE B 1 13  ? 78.111 -62.011  4.479   1.00 105.97 ? 11  PHE B C   1 
ATOM 3637 O O   . PHE B 1 13  ? 78.342 -60.808  4.536   1.00 84.86  ? 11  PHE B O   1 
ATOM 3638 C CB  . PHE B 1 13  ? 79.103 -63.365  2.824   1.00 94.13  ? 11  PHE B CB  1 
ATOM 3639 C CG  . PHE B 1 13  ? 80.231 -64.210  2.262   1.00 113.84 ? 11  PHE B CG  1 
ATOM 3640 C CD1 . PHE B 1 13  ? 81.366 -63.614  1.714   1.00 114.38 ? 11  PHE B CD1 1 
ATOM 3641 C CD2 . PHE B 1 13  ? 80.150 -65.598  2.260   1.00 133.33 ? 11  PHE B CD2 1 
ATOM 3642 C CE1 . PHE B 1 13  ? 82.395 -64.386  1.187   1.00 110.65 ? 11  PHE B CE1 1 
ATOM 3643 C CE2 . PHE B 1 13  ? 81.177 -66.366  1.714   1.00 126.16 ? 11  PHE B CE2 1 
ATOM 3644 C CZ  . PHE B 1 13  ? 82.294 -65.755  1.185   1.00 115.56 ? 11  PHE B CZ  1 
ATOM 3645 N N   . LEU B 1 14  ? 76.894 -62.546  4.553   1.00 135.72 ? 12  LEU B N   1 
ATOM 3646 C CA  . LEU B 1 14  ? 75.690 -61.740  4.633   1.00 120.90 ? 12  LEU B CA  1 
ATOM 3647 C C   . LEU B 1 14  ? 75.718 -60.912  5.916   1.00 111.88 ? 12  LEU B C   1 
ATOM 3648 O O   . LEU B 1 14  ? 75.361 -59.738  5.876   1.00 100.85 ? 12  LEU B O   1 
ATOM 3649 C CB  . LEU B 1 14  ? 74.449 -62.628  4.541   1.00 118.48 ? 12  LEU B CB  1 
ATOM 3650 C CG  . LEU B 1 14  ? 74.293 -63.501  3.287   1.00 129.03 ? 12  LEU B CG  1 
ATOM 3651 C CD1 . LEU B 1 14  ? 74.717 -62.776  2.009   1.00 128.64 ? 12  LEU B CD1 1 
ATOM 3652 C CD2 . LEU B 1 14  ? 75.008 -64.857  3.394   1.00 134.76 ? 12  LEU B CD2 1 
ATOM 3653 N N   . GLY B 1 15  ? 76.168 -61.492  7.041   1.00 115.89 ? 13  GLY B N   1 
ATOM 3654 C CA  . GLY B 1 15  ? 76.295 -60.699  8.260   1.00 106.16 ? 13  GLY B CA  1 
ATOM 3655 C C   . GLY B 1 15  ? 76.228 -61.541  9.530   1.00 111.78 ? 13  GLY B C   1 
ATOM 3656 O O   . GLY B 1 15  ? 76.464 -62.744  9.492   1.00 116.14 ? 13  GLY B O   1 
ATOM 3657 N N   . GLU B 1 16  ? 75.874 -60.886  10.638  1.00 125.55 ? 14  GLU B N   1 
ATOM 3658 C CA  . GLU B 1 16  ? 75.850 -61.503  11.956  1.00 133.88 ? 14  GLU B CA  1 
ATOM 3659 C C   . GLU B 1 16  ? 74.408 -61.863  12.300  1.00 112.99 ? 14  GLU B C   1 
ATOM 3660 O O   . GLU B 1 16  ? 73.493 -61.113  11.968  1.00 113.83 ? 14  GLU B O   1 
ATOM 3661 C CB  . GLU B 1 16  ? 76.441 -60.480  12.931  1.00 154.32 ? 14  GLU B CB  1 
ATOM 3662 C CG  . GLU B 1 16  ? 76.245 -60.767  14.420  1.00 161.43 ? 14  GLU B CG  1 
ATOM 3663 C CD  . GLU B 1 16  ? 76.106 -59.509  15.272  1.00 156.64 ? 14  GLU B CD  1 
ATOM 3664 O OE1 . GLU B 1 16  ? 76.776 -58.506  14.935  1.00 138.31 ? 14  GLU B OE1 1 
ATOM 3665 O OE2 . GLU B 1 16  ? 75.342 -59.524  16.271  1.00 147.35 ? 14  GLU B OE2 1 
ATOM 3666 N N   . LYS B 1 17  ? 74.226 -62.988  12.998  1.00 98.28  ? 15  LYS B N   1 
ATOM 3667 C CA  . LYS B 1 17  ? 72.888 -63.443  13.340  1.00 112.60 ? 15  LYS B CA  1 
ATOM 3668 C C   . LYS B 1 17  ? 72.810 -63.903  14.791  1.00 105.91 ? 15  LYS B C   1 
ATOM 3669 O O   . LYS B 1 17  ? 73.732 -64.568  15.260  1.00 107.19 ? 15  LYS B O   1 
ATOM 3670 C CB  . LYS B 1 17  ? 72.475 -64.593  12.410  1.00 129.61 ? 15  LYS B CB  1 
ATOM 3671 C CG  . LYS B 1 17  ? 71.108 -64.462  11.779  1.00 135.12 ? 15  LYS B CG  1 
ATOM 3672 C CD  . LYS B 1 17  ? 70.994 -63.217  10.903  1.00 125.16 ? 15  LYS B CD  1 
ATOM 3673 C CE  . LYS B 1 17  ? 69.594 -62.898  10.507  1.00 109.73 ? 15  LYS B CE  1 
ATOM 3674 N NZ  . LYS B 1 17  ? 69.538 -61.698  9.677   1.00 107.60 ? 15  LYS B NZ  1 
ATOM 3675 N N   . LYS B 1 18  ? 71.683 -63.570  15.443  1.00 108.73 ? 16  LYS B N   1 
ATOM 3676 C CA  . LYS B 1 18  ? 71.388 -64.010  16.799  1.00 114.80 ? 16  LYS B CA  1 
ATOM 3677 C C   . LYS B 1 18  ? 70.725 -65.388  16.766  1.00 110.91 ? 16  LYS B C   1 
ATOM 3678 O O   . LYS B 1 18  ? 69.587 -65.518  16.337  1.00 113.07 ? 16  LYS B O   1 
ATOM 3679 C CB  . LYS B 1 18  ? 70.533 -62.972  17.540  1.00 107.49 ? 16  LYS B CB  1 
ATOM 3680 C CG  . LYS B 1 18  ? 71.365 -61.858  18.184  1.00 123.51 ? 16  LYS B CG  1 
ATOM 3681 C CD  . LYS B 1 18  ? 70.770 -61.163  19.404  1.00 141.55 ? 16  LYS B CD  1 
ATOM 3682 C CE  . LYS B 1 18  ? 71.817 -60.865  20.457  1.00 157.61 ? 16  LYS B CE  1 
ATOM 3683 N NZ  . LYS B 1 18  ? 71.268 -60.524  21.771  1.00 157.41 ? 16  LYS B NZ  1 
ATOM 3684 N N   . ILE B 1 19  ? 71.454 -66.402  17.249  1.00 100.40 ? 17  ILE B N   1 
ATOM 3685 C CA  . ILE B 1 19  ? 70.927 -67.748  17.366  1.00 108.03 ? 17  ILE B CA  1 
ATOM 3686 C C   . ILE B 1 19  ? 70.502 -67.950  18.812  1.00 115.87 ? 17  ILE B C   1 
ATOM 3687 O O   . ILE B 1 19  ? 71.278 -67.646  19.710  1.00 130.07 ? 17  ILE B O   1 
ATOM 3688 C CB  . ILE B 1 19  ? 71.987 -68.798  16.985  1.00 119.75 ? 17  ILE B CB  1 
ATOM 3689 C CG1 . ILE B 1 19  ? 72.923 -68.332  15.856  1.00 118.84 ? 17  ILE B CG1 1 
ATOM 3690 C CG2 . ILE B 1 19  ? 71.329 -70.142  16.672  1.00 115.77 ? 17  ILE B CG2 1 
ATOM 3691 C CD1 . ILE B 1 19  ? 72.232 -67.915  14.573  1.00 117.79 ? 17  ILE B CD1 1 
ATOM 3692 N N   . PRO B 1 20  ? 69.290 -68.478  19.100  1.00 130.18 ? 18  PRO B N   1 
ATOM 3693 C CA  . PRO B 1 20  ? 69.001 -69.029  20.426  1.00 128.11 ? 18  PRO B CA  1 
ATOM 3694 C C   . PRO B 1 20  ? 70.158 -69.919  20.876  1.00 121.56 ? 18  PRO B C   1 
ATOM 3695 O O   . PRO B 1 20  ? 70.813 -70.541  20.040  1.00 132.93 ? 18  PRO B O   1 
ATOM 3696 C CB  . PRO B 1 20  ? 67.684 -69.798  20.199  1.00 121.21 ? 18  PRO B CB  1 
ATOM 3697 C CG  . PRO B 1 20  ? 66.994 -68.988  19.126  1.00 123.84 ? 18  PRO B CG  1 
ATOM 3698 C CD  . PRO B 1 20  ? 68.126 -68.530  18.205  1.00 129.44 ? 18  PRO B CD  1 
ATOM 3699 N N   . ALA B 1 21  ? 70.428 -69.940  22.188  1.00 108.70 ? 19  ALA B N   1 
ATOM 3700 C CA  . ALA B 1 21  ? 71.555 -70.684  22.734  1.00 110.61 ? 19  ALA B CA  1 
ATOM 3701 C C   . ALA B 1 21  ? 71.226 -72.171  22.805  1.00 122.86 ? 19  ALA B C   1 
ATOM 3702 O O   . ALA B 1 21  ? 72.128 -73.010  22.739  1.00 137.38 ? 19  ALA B O   1 
ATOM 3703 C CB  . ALA B 1 21  ? 71.937 -70.158  24.099  1.00 104.35 ? 19  ALA B CB  1 
ATOM 3704 N N   . ASP B 1 22  ? 69.929 -72.483  22.957  1.00 118.73 ? 20  ASP B N   1 
ATOM 3705 C CA  . ASP B 1 22  ? 69.482 -73.864  22.990  1.00 118.36 ? 20  ASP B CA  1 
ATOM 3706 C C   . ASP B 1 22  ? 69.697 -74.500  21.618  1.00 125.05 ? 20  ASP B C   1 
ATOM 3707 O O   . ASP B 1 22  ? 69.904 -75.704  21.538  1.00 139.88 ? 20  ASP B O   1 
ATOM 3708 C CB  . ASP B 1 22  ? 68.068 -73.990  23.546  1.00 117.64 ? 20  ASP B CB  1 
ATOM 3709 C CG  . ASP B 1 22  ? 67.971 -74.202  25.056  1.00 116.72 ? 20  ASP B CG  1 
ATOM 3710 O OD1 . ASP B 1 22  ? 68.745 -73.574  25.794  1.00 113.22 ? 20  ASP B OD1 1 
ATOM 3711 O OD2 . ASP B 1 22  ? 67.104 -74.983  25.510  1.00 115.30 ? 20  ASP B OD2 1 
ATOM 3712 N N   . ALA B 1 23  ? 69.695 -73.685  20.555  1.00 125.12 ? 21  ALA B N   1 
ATOM 3713 C CA  . ALA B 1 23  ? 69.672 -74.175  19.185  1.00 128.59 ? 21  ALA B CA  1 
ATOM 3714 C C   . ALA B 1 23  ? 71.007 -74.789  18.760  1.00 121.02 ? 21  ALA B C   1 
ATOM 3715 O O   . ALA B 1 23  ? 72.053 -74.152  18.852  1.00 109.73 ? 21  ALA B O   1 
ATOM 3716 C CB  . ALA B 1 23  ? 69.297 -73.048  18.255  1.00 137.92 ? 21  ALA B CB  1 
ATOM 3717 N N   . TYR B 1 24  ? 70.936 -76.026  18.247  1.00 120.78 ? 22  TYR B N   1 
ATOM 3718 C CA  . TYR B 1 24  ? 72.069 -76.724  17.656  1.00 102.16 ? 22  TYR B CA  1 
ATOM 3719 C C   . TYR B 1 24  ? 72.245 -76.293  16.207  1.00 91.82  ? 22  TYR B C   1 
ATOM 3720 O O   . TYR B 1 24  ? 73.263 -76.607  15.603  1.00 96.62  ? 22  TYR B O   1 
ATOM 3721 C CB  . TYR B 1 24  ? 71.858 -78.239  17.640  1.00 99.89  ? 22  TYR B CB  1 
ATOM 3722 C CG  . TYR B 1 24  ? 71.775 -78.893  19.011  1.00 101.72 ? 22  TYR B CG  1 
ATOM 3723 C CD1 . TYR B 1 24  ? 70.620 -78.806  19.785  1.00 93.47  ? 22  TYR B CD1 1 
ATOM 3724 C CD2 . TYR B 1 24  ? 72.844 -79.624  19.512  1.00 103.17 ? 22  TYR B CD2 1 
ATOM 3725 C CE1 . TYR B 1 24  ? 70.536 -79.408  21.026  1.00 87.66  ? 22  TYR B CE1 1 
ATOM 3726 C CE2 . TYR B 1 24  ? 72.760 -80.250  20.742  1.00 96.67  ? 22  TYR B CE2 1 
ATOM 3727 C CZ  . TYR B 1 24  ? 71.616 -80.123  21.504  1.00 90.63  ? 22  TYR B CZ  1 
ATOM 3728 O OH  . TYR B 1 24  ? 71.574 -80.705  22.728  1.00 94.99  ? 22  TYR B OH  1 
ATOM 3729 N N   . TYR B 1 25  ? 71.230 -75.620  15.651  1.00 85.50  ? 23  TYR B N   1 
ATOM 3730 C CA  . TYR B 1 25  ? 71.270 -75.184  14.265  1.00 87.04  ? 23  TYR B CA  1 
ATOM 3731 C C   . TYR B 1 25  ? 72.004 -73.847  14.164  1.00 86.05  ? 23  TYR B C   1 
ATOM 3732 O O   . TYR B 1 25  ? 72.026 -73.075  15.123  1.00 94.93  ? 23  TYR B O   1 
ATOM 3733 C CB  . TYR B 1 25  ? 69.837 -75.143  13.728  1.00 85.40  ? 23  TYR B CB  1 
ATOM 3734 C CG  . TYR B 1 25  ? 68.926 -74.121  14.392  1.00 79.70  ? 23  TYR B CG  1 
ATOM 3735 C CD1 . TYR B 1 25  ? 69.088 -72.757  14.155  1.00 77.82  ? 23  TYR B CD1 1 
ATOM 3736 C CD2 . TYR B 1 25  ? 67.886 -74.522  15.225  1.00 76.48  ? 23  TYR B CD2 1 
ATOM 3737 C CE1 . TYR B 1 25  ? 68.261 -71.819  14.752  1.00 73.85  ? 23  TYR B CE1 1 
ATOM 3738 C CE2 . TYR B 1 25  ? 67.051 -73.595  15.830  1.00 69.70  ? 23  TYR B CE2 1 
ATOM 3739 C CZ  . TYR B 1 25  ? 67.241 -72.242  15.588  1.00 71.91  ? 23  TYR B CZ  1 
ATOM 3740 O OH  . TYR B 1 25  ? 66.430 -71.304  16.152  1.00 72.62  ? 23  TYR B OH  1 
ATOM 3741 N N   . GLY B 1 26  ? 72.587 -73.581  12.986  1.00 83.88  ? 24  GLY B N   1 
ATOM 3742 C CA  . GLY B 1 26  ? 73.505 -72.467  12.812  1.00 94.02  ? 24  GLY B CA  1 
ATOM 3743 C C   . GLY B 1 26  ? 72.871 -71.327  12.019  1.00 98.39  ? 24  GLY B C   1 
ATOM 3744 O O   . GLY B 1 26  ? 71.650 -71.164  12.051  1.00 102.46 ? 24  GLY B O   1 
ATOM 3745 N N   . ILE B 1 27  ? 73.718 -70.550  11.318  1.00 99.31  ? 25  ILE B N   1 
ATOM 3746 C CA  . ILE B 1 27  ? 73.283 -69.328  10.656  1.00 95.50  ? 25  ILE B CA  1 
ATOM 3747 C C   . ILE B 1 27  ? 72.692 -69.677  9.295   1.00 101.74 ? 25  ILE B C   1 
ATOM 3748 O O   . ILE B 1 27  ? 71.660 -69.136  8.901   1.00 101.76 ? 25  ILE B O   1 
ATOM 3749 C CB  . ILE B 1 27  ? 74.423 -68.298  10.522  1.00 86.85  ? 25  ILE B CB  1 
ATOM 3750 C CG1 . ILE B 1 27  ? 73.879 -66.929  10.192  1.00 95.83  ? 25  ILE B CG1 1 
ATOM 3751 C CG2 . ILE B 1 27  ? 75.478 -68.726  9.500   1.00 81.89  ? 25  ILE B CG2 1 
ATOM 3752 C CD1 . ILE B 1 27  ? 74.928 -65.827  10.223  1.00 108.56 ? 25  ILE B CD1 1 
ATOM 3753 N N   . GLN B 1 28  ? 73.353 -70.579  8.568   1.00 98.42  ? 26  GLN B N   1 
ATOM 3754 C CA  . GLN B 1 28  ? 72.904 -70.902  7.229   1.00 88.89  ? 26  GLN B CA  1 
ATOM 3755 C C   . GLN B 1 28  ? 71.490 -71.474  7.303   1.00 76.74  ? 26  GLN B C   1 
ATOM 3756 O O   . GLN B 1 28  ? 70.708 -71.281  6.379   1.00 103.99 ? 26  GLN B O   1 
ATOM 3757 C CB  . GLN B 1 28  ? 73.948 -71.768  6.535   1.00 95.65  ? 26  GLN B CB  1 
ATOM 3758 C CG  . GLN B 1 28  ? 75.256 -71.025  6.298   1.00 114.01 ? 26  GLN B CG  1 
ATOM 3759 C CD  . GLN B 1 28  ? 76.149 -71.734  5.305   1.00 139.02 ? 26  GLN B CD  1 
ATOM 3760 O OE1 . GLN B 1 28  ? 75.749 -72.004  4.169   1.00 159.51 ? 26  GLN B OE1 1 
ATOM 3761 N NE2 . GLN B 1 28  ? 77.364 -72.063  5.717   1.00 151.49 ? 26  GLN B NE2 1 
ATOM 3762 N N   . THR B 1 29  ? 71.149 -72.138  8.407   1.00 60.47  ? 27  THR B N   1 
ATOM 3763 C CA  . THR B 1 29  ? 69.788 -72.599  8.626   1.00 68.58  ? 27  THR B CA  1 
ATOM 3764 C C   . THR B 1 29  ? 68.865 -71.419  8.944   1.00 78.65  ? 27  THR B C   1 
ATOM 3765 O O   . THR B 1 29  ? 67.700 -71.397  8.548   1.00 84.70  ? 27  THR B O   1 
ATOM 3766 C CB  . THR B 1 29  ? 69.783 -73.640  9.744   1.00 69.00  ? 27  THR B CB  1 
ATOM 3767 O OG1 . THR B 1 29  ? 70.380 -74.780  9.135   1.00 65.90  ? 27  THR B OG1 1 
ATOM 3768 C CG2 . THR B 1 29  ? 68.393 -73.952  10.273  1.00 66.44  ? 27  THR B CG2 1 
ATOM 3769 N N   . LEU B 1 30  ? 69.377 -70.450  9.702   1.00 84.86  ? 28  LEU B N   1 
ATOM 3770 C CA  . LEU B 1 30  ? 68.588 -69.295  10.099  1.00 89.02  ? 28  LEU B CA  1 
ATOM 3771 C C   . LEU B 1 30  ? 68.263 -68.460  8.859   1.00 90.17  ? 28  LEU B C   1 
ATOM 3772 O O   . LEU B 1 30  ? 67.178 -67.900  8.739   1.00 85.94  ? 28  LEU B O   1 
ATOM 3773 C CB  . LEU B 1 30  ? 69.355 -68.512  11.169  1.00 92.81  ? 28  LEU B CB  1 
ATOM 3774 C CG  . LEU B 1 30  ? 68.630 -67.366  11.891  1.00 91.33  ? 28  LEU B CG  1 
ATOM 3775 C CD1 . LEU B 1 30  ? 69.151 -67.192  13.327  1.00 102.43 ? 28  LEU B CD1 1 
ATOM 3776 C CD2 . LEU B 1 30  ? 68.787 -66.048  11.157  1.00 105.31 ? 28  LEU B CD2 1 
ATOM 3777 N N   . ARG B 1 31  ? 69.216 -68.365  7.929   1.00 90.09  ? 29  ARG B N   1 
ATOM 3778 C CA  . ARG B 1 31  ? 68.981 -67.614  6.705   1.00 96.56  ? 29  ARG B CA  1 
ATOM 3779 C C   . ARG B 1 31  ? 67.789 -68.224  5.958   1.00 96.56  ? 29  ARG B C   1 
ATOM 3780 O O   . ARG B 1 31  ? 66.904 -67.510  5.481   1.00 94.43  ? 29  ARG B O   1 
ATOM 3781 C CB  . ARG B 1 31  ? 70.237 -67.606  5.822   1.00 105.05 ? 29  ARG B CB  1 
ATOM 3782 C CG  . ARG B 1 31  ? 71.490 -66.948  6.383   1.00 119.14 ? 29  ARG B CG  1 
ATOM 3783 C CD  . ARG B 1 31  ? 71.783 -65.564  5.829   1.00 129.29 ? 29  ARG B CD  1 
ATOM 3784 N NE  . ARG B 1 31  ? 72.903 -64.948  6.550   1.00 137.52 ? 29  ARG B NE  1 
ATOM 3785 C CZ  . ARG B 1 31  ? 72.829 -63.834  7.273   1.00 130.86 ? 29  ARG B CZ  1 
ATOM 3786 N NH1 . ARG B 1 31  ? 71.674 -63.205  7.420   1.00 124.70 ? 29  ARG B NH1 1 
ATOM 3787 N NH2 . ARG B 1 31  ? 73.908 -63.339  7.851   1.00 137.48 ? 29  ARG B NH2 1 
ATOM 3788 N N   . ALA B 1 32  ? 67.776 -69.562  5.873   1.00 88.25  ? 30  ALA B N   1 
ATOM 3789 C CA  . ALA B 1 32  ? 66.839 -70.284  5.032   1.00 80.69  ? 30  ALA B CA  1 
ATOM 3790 C C   . ALA B 1 32  ? 65.442 -70.243  5.645   1.00 87.17  ? 30  ALA B C   1 
ATOM 3791 O O   . ALA B 1 32  ? 64.443 -70.224  4.928   1.00 96.69  ? 30  ALA B O   1 
ATOM 3792 C CB  . ALA B 1 32  ? 67.321 -71.698  4.843   1.00 75.08  ? 30  ALA B CB  1 
ATOM 3793 N N   . THR B 1 33  ? 65.374 -70.242  6.979   1.00 84.19  ? 31  THR B N   1 
ATOM 3794 C CA  . THR B 1 33  ? 64.092 -70.118  7.656   1.00 85.53  ? 31  THR B CA  1 
ATOM 3795 C C   . THR B 1 33  ? 63.523 -68.720  7.422   1.00 83.35  ? 31  THR B C   1 
ATOM 3796 O O   . THR B 1 33  ? 62.313 -68.552  7.437   1.00 89.56  ? 31  THR B O   1 
ATOM 3797 C CB  . THR B 1 33  ? 64.226 -70.444  9.141   1.00 81.27  ? 31  THR B CB  1 
ATOM 3798 O OG1 . THR B 1 33  ? 65.394 -69.751  9.556   1.00 97.77  ? 31  THR B OG1 1 
ATOM 3799 C CG2 . THR B 1 33  ? 64.477 -71.917  9.401   1.00 86.17  ? 31  THR B CG2 1 
ATOM 3800 N N   . GLU B 1 34  ? 64.384 -67.723  7.186   1.00 80.58  ? 32  GLU B N   1 
ATOM 3801 C CA  . GLU B 1 34  ? 63.915 -66.383  6.856   1.00 86.89  ? 32  GLU B CA  1 
ATOM 3802 C C   . GLU B 1 34  ? 63.616 -66.278  5.365   1.00 82.74  ? 32  GLU B C   1 
ATOM 3803 O O   . GLU B 1 34  ? 62.673 -65.594  4.968   1.00 68.53  ? 32  GLU B O   1 
ATOM 3804 C CB  . GLU B 1 34  ? 64.927 -65.301  7.233   1.00 95.69  ? 32  GLU B CB  1 
ATOM 3805 C CG  . GLU B 1 34  ? 64.978 -65.040  8.738   1.00 103.95 ? 32  GLU B CG  1 
ATOM 3806 C CD  . GLU B 1 34  ? 66.085 -64.116  9.211   1.00 104.76 ? 32  GLU B CD  1 
ATOM 3807 O OE1 . GLU B 1 34  ? 67.245 -64.471  8.903   1.00 99.13  ? 32  GLU B OE1 1 
ATOM 3808 O OE2 . GLU B 1 34  ? 65.810 -63.101  9.898   1.00 109.60 ? 32  GLU B OE2 1 
ATOM 3809 N N   . ASN B 1 35  ? 64.456 -66.939  4.561   1.00 80.33  ? 33  ASN B N   1 
ATOM 3810 C CA  . ASN B 1 35  ? 64.391 -66.843  3.112   1.00 77.92  ? 33  ASN B CA  1 
ATOM 3811 C C   . ASN B 1 35  ? 63.160 -67.571  2.574   1.00 76.32  ? 33  ASN B C   1 
ATOM 3812 O O   . ASN B 1 35  ? 62.568 -67.141  1.589   1.00 83.49  ? 33  ASN B O   1 
ATOM 3813 C CB  . ASN B 1 35  ? 65.641 -67.420  2.454   1.00 76.63  ? 33  ASN B CB  1 
ATOM 3814 C CG  . ASN B 1 35  ? 66.841 -66.512  2.545   1.00 73.83  ? 33  ASN B CG  1 
ATOM 3815 O OD1 . ASN B 1 35  ? 66.692 -65.292  2.693   1.00 66.63  ? 33  ASN B OD1 1 
ATOM 3816 N ND2 . ASN B 1 35  ? 68.026 -67.093  2.405   1.00 74.15  ? 33  ASN B ND2 1 
ATOM 3817 N N   . PHE B 1 36  ? 62.790 -68.686  3.215   1.00 69.26  ? 34  PHE B N   1 
ATOM 3818 C CA  . PHE B 1 36  ? 61.784 -69.587  2.674   1.00 67.36  ? 34  PHE B CA  1 
ATOM 3819 C C   . PHE B 1 36  ? 60.756 -69.923  3.749   1.00 64.84  ? 34  PHE B C   1 
ATOM 3820 O O   . PHE B 1 36  ? 60.623 -71.084  4.154   1.00 54.66  ? 34  PHE B O   1 
ATOM 3821 C CB  . PHE B 1 36  ? 62.460 -70.851  2.138   1.00 68.05  ? 34  PHE B CB  1 
ATOM 3822 C CG  . PHE B 1 36  ? 63.645 -70.553  1.237   1.00 64.13  ? 34  PHE B CG  1 
ATOM 3823 C CD1 . PHE B 1 36  ? 63.554 -69.607  0.224   1.00 65.51  ? 34  PHE B CD1 1 
ATOM 3824 C CD2 . PHE B 1 36  ? 64.863 -71.182  1.450   1.00 64.71  ? 34  PHE B CD2 1 
ATOM 3825 C CE1 . PHE B 1 36  ? 64.645 -69.332  -0.583  1.00 70.96  ? 34  PHE B CE1 1 
ATOM 3826 C CE2 . PHE B 1 36  ? 65.950 -70.897  0.651   1.00 72.01  ? 34  PHE B CE2 1 
ATOM 3827 C CZ  . PHE B 1 36  ? 65.837 -69.979  -0.369  1.00 74.33  ? 34  PHE B CZ  1 
ATOM 3828 N N   . PRO B 1 37  ? 59.996 -68.905  4.218   1.00 58.65  ? 35  PRO B N   1 
ATOM 3829 C CA  . PRO B 1 37  ? 58.886 -69.127  5.137   1.00 54.41  ? 35  PRO B CA  1 
ATOM 3830 C C   . PRO B 1 37  ? 57.642 -69.481  4.337   1.00 61.10  ? 35  PRO B C   1 
ATOM 3831 O O   . PRO B 1 37  ? 56.714 -68.674  4.246   1.00 67.48  ? 35  PRO B O   1 
ATOM 3832 C CB  . PRO B 1 37  ? 58.795 -67.767  5.820   1.00 49.63  ? 35  PRO B CB  1 
ATOM 3833 C CG  . PRO B 1 37  ? 59.118 -66.785  4.718   1.00 51.62  ? 35  PRO B CG  1 
ATOM 3834 C CD  . PRO B 1 37  ? 60.186 -67.477  3.899   1.00 53.38  ? 35  PRO B CD  1 
ATOM 3835 N N   . ILE B 1 38  ? 57.631 -70.692  3.763   1.00 59.97  ? 36  ILE B N   1 
ATOM 3836 C CA  . ILE B 1 38  ? 56.649 -70.997  2.740   1.00 62.68  ? 36  ILE B CA  1 
ATOM 3837 C C   . ILE B 1 38  ? 55.475 -71.772  3.329   1.00 57.48  ? 36  ILE B C   1 
ATOM 3838 O O   . ILE B 1 38  ? 54.358 -71.265  3.330   1.00 62.75  ? 36  ILE B O   1 
ATOM 3839 C CB  . ILE B 1 38  ? 57.296 -71.723  1.555   1.00 69.73  ? 36  ILE B CB  1 
ATOM 3840 C CG1 . ILE B 1 38  ? 58.479 -70.927  0.995   1.00 76.61  ? 36  ILE B CG1 1 
ATOM 3841 C CG2 . ILE B 1 38  ? 56.244 -72.012  0.482   1.00 74.13  ? 36  ILE B CG2 1 
ATOM 3842 C CD1 . ILE B 1 38  ? 58.168 -69.472  0.671   1.00 81.79  ? 36  ILE B CD1 1 
ATOM 3843 N N   . THR B 1 39  ? 55.718 -73.011  3.757   1.00 49.48  ? 37  THR B N   1 
ATOM 3844 C CA  . THR B 1 39  ? 54.670 -73.865  4.284   1.00 51.49  ? 37  THR B CA  1 
ATOM 3845 C C   . THR B 1 39  ? 54.763 -73.913  5.796   1.00 63.05  ? 37  THR B C   1 
ATOM 3846 O O   . THR B 1 39  ? 53.793 -74.280  6.457   1.00 68.63  ? 37  THR B O   1 
ATOM 3847 C CB  . THR B 1 39  ? 54.846 -75.275  3.744   1.00 54.12  ? 37  THR B CB  1 
ATOM 3848 O OG1 . THR B 1 39  ? 56.149 -75.721  4.140   1.00 50.58  ? 37  THR B OG1 1 
ATOM 3849 C CG2 . THR B 1 39  ? 54.639 -75.310  2.242   1.00 56.90  ? 37  THR B CG2 1 
ATOM 3850 N N   . GLY B 1 40  ? 55.977 -73.641  6.295   1.00 70.40  ? 38  GLY B N   1 
ATOM 3851 C CA  . GLY B 1 40  ? 56.378 -73.948  7.659   1.00 64.07  ? 38  GLY B CA  1 
ATOM 3852 C C   . GLY B 1 40  ? 56.140 -75.411  8.042   1.00 57.76  ? 38  GLY B C   1 
ATOM 3853 O O   . GLY B 1 40  ? 55.870 -75.702  9.192   1.00 61.62  ? 38  GLY B O   1 
ATOM 3854 N N   . TYR B 1 41  ? 56.218 -76.349  7.100   1.00 58.53  ? 39  TYR B N   1 
ATOM 3855 C CA  . TYR B 1 41  ? 56.281 -77.748  7.482   1.00 58.91  ? 39  TYR B CA  1 
ATOM 3856 C C   . TYR B 1 41  ? 57.715 -78.062  7.897   1.00 63.56  ? 39  TYR B C   1 
ATOM 3857 O O   . TYR B 1 41  ? 58.589 -77.202  7.857   1.00 66.18  ? 39  TYR B O   1 
ATOM 3858 C CB  . TYR B 1 41  ? 55.794 -78.631  6.330   1.00 65.83  ? 39  TYR B CB  1 
ATOM 3859 C CG  . TYR B 1 41  ? 54.314 -78.506  6.012   1.00 64.48  ? 39  TYR B CG  1 
ATOM 3860 C CD1 . TYR B 1 41  ? 53.362 -78.555  7.017   1.00 62.01  ? 39  TYR B CD1 1 
ATOM 3861 C CD2 . TYR B 1 41  ? 53.870 -78.345  4.709   1.00 65.33  ? 39  TYR B CD2 1 
ATOM 3862 C CE1 . TYR B 1 41  ? 52.011 -78.460  6.738   1.00 61.22  ? 39  TYR B CE1 1 
ATOM 3863 C CE2 . TYR B 1 41  ? 52.521 -78.214  4.421   1.00 64.84  ? 39  TYR B CE2 1 
ATOM 3864 C CZ  . TYR B 1 41  ? 51.590 -78.285  5.438   1.00 62.37  ? 39  TYR B CZ  1 
ATOM 3865 O OH  . TYR B 1 41  ? 50.262 -78.164  5.170   1.00 69.79  ? 39  TYR B OH  1 
ATOM 3866 N N   . ARG B 1 42  ? 57.943 -79.301  8.328   1.00 67.72  ? 40  ARG B N   1 
ATOM 3867 C CA  . ARG B 1 42  ? 59.282 -79.783  8.606   1.00 70.85  ? 40  ARG B CA  1 
ATOM 3868 C C   . ARG B 1 42  ? 59.588 -80.897  7.614   1.00 66.14  ? 40  ARG B C   1 
ATOM 3869 O O   . ARG B 1 42  ? 58.682 -81.592  7.153   1.00 61.64  ? 40  ARG B O   1 
ATOM 3870 C CB  . ARG B 1 42  ? 59.367 -80.366  10.015  1.00 85.90  ? 40  ARG B CB  1 
ATOM 3871 C CG  . ARG B 1 42  ? 58.945 -79.408  11.117  1.00 106.95 ? 40  ARG B CG  1 
ATOM 3872 C CD  . ARG B 1 42  ? 59.946 -78.305  11.411  1.00 115.95 ? 40  ARG B CD  1 
ATOM 3873 N NE  . ARG B 1 42  ? 59.899 -77.895  12.825  1.00 121.41 ? 40  ARG B NE  1 
ATOM 3874 C CZ  . ARG B 1 42  ? 60.222 -78.670  13.873  1.00 124.93 ? 40  ARG B CZ  1 
ATOM 3875 N NH1 . ARG B 1 42  ? 60.635 -79.916  13.714  1.00 116.24 ? 40  ARG B NH1 1 
ATOM 3876 N NH2 . ARG B 1 42  ? 60.139 -78.197  15.105  1.00 127.88 ? 40  ARG B NH2 1 
ATOM 3877 N N   . ILE B 1 43  ? 60.876 -81.086  7.323   1.00 63.66  ? 41  ILE B N   1 
ATOM 3878 C CA  . ILE B 1 43  ? 61.271 -82.098  6.359   1.00 63.28  ? 41  ILE B CA  1 
ATOM 3879 C C   . ILE B 1 43  ? 60.939 -83.463  6.957   1.00 66.37  ? 41  ILE B C   1 
ATOM 3880 O O   . ILE B 1 43  ? 60.940 -83.638  8.173   1.00 61.40  ? 41  ILE B O   1 
ATOM 3881 C CB  . ILE B 1 43  ? 62.753 -81.956  5.967   1.00 64.75  ? 41  ILE B CB  1 
ATOM 3882 C CG1 . ILE B 1 43  ? 63.665 -82.580  6.999   1.00 73.03  ? 41  ILE B CG1 1 
ATOM 3883 C CG2 . ILE B 1 43  ? 63.124 -80.490  5.712   1.00 64.50  ? 41  ILE B CG2 1 
ATOM 3884 C CD1 . ILE B 1 43  ? 65.103 -82.712  6.553   1.00 80.46  ? 41  ILE B CD1 1 
ATOM 3885 N N   . HIS B 1 44  ? 60.650 -84.439  6.095   1.00 78.92  ? 42  HIS B N   1 
ATOM 3886 C CA  . HIS B 1 44  ? 60.153 -85.717  6.570   1.00 85.37  ? 42  HIS B CA  1 
ATOM 3887 C C   . HIS B 1 44  ? 61.152 -86.290  7.574   1.00 82.00  ? 42  HIS B C   1 
ATOM 3888 O O   . HIS B 1 44  ? 62.349 -86.024  7.494   1.00 75.78  ? 42  HIS B O   1 
ATOM 3889 C CB  . HIS B 1 44  ? 59.820 -86.642  5.392   1.00 89.34  ? 42  HIS B CB  1 
ATOM 3890 C CG  . HIS B 1 44  ? 58.989 -87.817  5.798   1.00 92.49  ? 42  HIS B CG  1 
ATOM 3891 N ND1 . HIS B 1 44  ? 59.511 -88.924  6.433   1.00 82.10  ? 42  HIS B ND1 1 
ATOM 3892 C CD2 . HIS B 1 44  ? 57.668 -88.040  5.686   1.00 97.57  ? 42  HIS B CD2 1 
ATOM 3893 C CE1 . HIS B 1 44  ? 58.540 -89.793  6.662   1.00 87.20  ? 42  HIS B CE1 1 
ATOM 3894 N NE2 . HIS B 1 44  ? 57.411 -89.281  6.213   1.00 90.34  ? 42  HIS B NE2 1 
ATOM 3895 N N   . GLU B 1 45  ? 60.633 -87.053  8.539   1.00 87.02  ? 43  GLU B N   1 
ATOM 3896 C CA  . GLU B 1 45  ? 61.443 -87.571  9.630   1.00 100.85 ? 43  GLU B CA  1 
ATOM 3897 C C   . GLU B 1 45  ? 62.460 -88.550  9.057   1.00 80.86  ? 43  GLU B C   1 
ATOM 3898 O O   . GLU B 1 45  ? 63.610 -88.622  9.485   1.00 80.41  ? 43  GLU B O   1 
ATOM 3899 C CB  . GLU B 1 45  ? 60.554 -88.226  10.691  1.00 121.97 ? 43  GLU B CB  1 
ATOM 3900 C CG  . GLU B 1 45  ? 59.564 -87.253  11.332  1.00 136.71 ? 43  GLU B CG  1 
ATOM 3901 C CD  . GLU B 1 45  ? 60.200 -86.027  11.977  1.00 142.81 ? 43  GLU B CD  1 
ATOM 3902 O OE1 . GLU B 1 45  ? 60.943 -86.254  12.950  1.00 140.52 ? 43  GLU B OE1 1 
ATOM 3903 O OE2 . GLU B 1 45  ? 59.981 -84.868  11.531  1.00 139.37 ? 43  GLU B OE2 1 
ATOM 3904 N N   . GLU B 1 46  ? 62.017 -89.263  8.032   1.00 72.12  ? 44  GLU B N   1 
ATOM 3905 C CA  . GLU B 1 46  ? 62.786 -90.359  7.492   1.00 73.17  ? 44  GLU B CA  1 
ATOM 3906 C C   . GLU B 1 46  ? 63.947 -89.826  6.648   1.00 67.27  ? 44  GLU B C   1 
ATOM 3907 O O   . GLU B 1 46  ? 64.941 -90.529  6.448   1.00 60.03  ? 44  GLU B O   1 
ATOM 3908 C CB  . GLU B 1 46  ? 61.721 -91.211  6.810   1.00 79.20  ? 44  GLU B CB  1 
ATOM 3909 C CG  . GLU B 1 46  ? 62.191 -92.626  6.524   1.00 96.26  ? 44  GLU B CG  1 
ATOM 3910 C CD  . GLU B 1 46  ? 62.743 -93.321  7.749   1.00 106.58 ? 44  GLU B CD  1 
ATOM 3911 O OE1 . GLU B 1 46  ? 62.005 -93.370  8.775   1.00 87.30  ? 44  GLU B OE1 1 
ATOM 3912 O OE2 . GLU B 1 46  ? 63.916 -93.779  7.661   1.00 118.21 ? 44  GLU B OE2 1 
ATOM 3913 N N   . LEU B 1 47  ? 63.815 -88.574  6.179   1.00 69.20  ? 45  LEU B N   1 
ATOM 3914 C CA  . LEU B 1 47  ? 64.896 -87.874  5.495   1.00 74.90  ? 45  LEU B CA  1 
ATOM 3915 C C   . LEU B 1 47  ? 65.971 -87.477  6.505   1.00 77.35  ? 45  LEU B C   1 
ATOM 3916 O O   . LEU B 1 47  ? 67.168 -87.585  6.233   1.00 71.00  ? 45  LEU B O   1 
ATOM 3917 C CB  . LEU B 1 47  ? 64.404 -86.638  4.733   1.00 69.63  ? 45  LEU B CB  1 
ATOM 3918 C CG  . LEU B 1 47  ? 65.450 -85.889  3.894   1.00 62.81  ? 45  LEU B CG  1 
ATOM 3919 C CD1 . LEU B 1 47  ? 65.996 -86.763  2.789   1.00 64.01  ? 45  LEU B CD1 1 
ATOM 3920 C CD2 . LEU B 1 47  ? 64.930 -84.615  3.265   1.00 64.45  ? 45  LEU B CD2 1 
ATOM 3921 N N   . ILE B 1 48  ? 65.536 -86.974  7.664   1.00 76.11  ? 46  ILE B N   1 
ATOM 3922 C CA  . ILE B 1 48  ? 66.481 -86.562  8.685   1.00 69.72  ? 46  ILE B CA  1 
ATOM 3923 C C   . ILE B 1 48  ? 67.344 -87.769  9.039   1.00 69.97  ? 46  ILE B C   1 
ATOM 3924 O O   . ILE B 1 48  ? 68.569 -87.673  8.997   1.00 70.01  ? 46  ILE B O   1 
ATOM 3925 C CB  . ILE B 1 48  ? 65.760 -85.970  9.905   1.00 65.61  ? 46  ILE B CB  1 
ATOM 3926 C CG1 . ILE B 1 48  ? 65.057 -84.672  9.564   1.00 63.62  ? 46  ILE B CG1 1 
ATOM 3927 C CG2 . ILE B 1 48  ? 66.744 -85.766  11.048  1.00 73.68  ? 46  ILE B CG2 1 
ATOM 3928 C CD1 . ILE B 1 48  ? 63.994 -84.267  10.563  1.00 62.76  ? 46  ILE B CD1 1 
ATOM 3929 N N   . ARG B 1 49  ? 66.694 -88.902  9.346   1.00 71.87  ? 47  ARG B N   1 
ATOM 3930 C CA  . ARG B 1 49  ? 67.395 -90.146  9.639   1.00 75.19  ? 47  ARG B CA  1 
ATOM 3931 C C   . ARG B 1 49  ? 68.412 -90.457  8.534   1.00 77.28  ? 47  ARG B C   1 
ATOM 3932 O O   . ARG B 1 49  ? 69.568 -90.799  8.794   1.00 65.92  ? 47  ARG B O   1 
ATOM 3933 C CB  . ARG B 1 49  ? 66.420 -91.313  9.834   1.00 77.60  ? 47  ARG B CB  1 
ATOM 3934 C CG  . ARG B 1 49  ? 65.842 -91.439  11.241  1.00 87.55  ? 47  ARG B CG  1 
ATOM 3935 C CD  . ARG B 1 49  ? 64.996 -92.713  11.493  1.00 96.23  ? 47  ARG B CD  1 
ATOM 3936 N NE  . ARG B 1 49  ? 65.067 -93.736  10.437  1.00 113.32 ? 47  ARG B NE  1 
ATOM 3937 C CZ  . ARG B 1 49  ? 65.892 -94.788  10.342  1.00 124.44 ? 47  ARG B CZ  1 
ATOM 3938 N NH1 . ARG B 1 49  ? 66.778 -95.025  11.294  1.00 127.45 ? 47  ARG B NH1 1 
ATOM 3939 N NH2 . ARG B 1 49  ? 65.828 -95.582  9.277   1.00 122.19 ? 47  ARG B NH2 1 
ATOM 3940 N N   . ALA B 1 50  ? 67.975 -90.333  7.280   1.00 76.62  ? 48  ALA B N   1 
ATOM 3941 C CA  . ALA B 1 50  ? 68.832 -90.706  6.173   1.00 76.20  ? 48  ALA B CA  1 
ATOM 3942 C C   . ALA B 1 50  ? 70.035 -89.767  6.114   1.00 77.78  ? 48  ALA B C   1 
ATOM 3943 O O   . ALA B 1 50  ? 71.166 -90.198  5.908   1.00 79.70  ? 48  ALA B O   1 
ATOM 3944 C CB  . ALA B 1 50  ? 68.031 -90.699  4.892   1.00 79.41  ? 48  ALA B CB  1 
ATOM 3945 N N   . LEU B 1 51  ? 69.761 -88.473  6.297   1.00 84.62  ? 49  LEU B N   1 
ATOM 3946 C CA  . LEU B 1 51  ? 70.787 -87.445  6.240   1.00 85.98  ? 49  LEU B CA  1 
ATOM 3947 C C   . LEU B 1 51  ? 71.905 -87.764  7.229   1.00 85.10  ? 49  LEU B C   1 
ATOM 3948 O O   . LEU B 1 51  ? 73.084 -87.608  6.905   1.00 79.06  ? 49  LEU B O   1 
ATOM 3949 C CB  . LEU B 1 51  ? 70.143 -86.093  6.534   1.00 80.93  ? 49  LEU B CB  1 
ATOM 3950 C CG  . LEU B 1 51  ? 69.443 -85.438  5.343   1.00 70.61  ? 49  LEU B CG  1 
ATOM 3951 C CD1 . LEU B 1 51  ? 68.359 -84.490  5.772   1.00 66.86  ? 49  LEU B CD1 1 
ATOM 3952 C CD2 . LEU B 1 51  ? 70.488 -84.722  4.505   1.00 69.22  ? 49  LEU B CD2 1 
ATOM 3953 N N   . ALA B 1 52  ? 71.500 -88.216  8.422   1.00 83.39  ? 50  ALA B N   1 
ATOM 3954 C CA  . ALA B 1 52  ? 72.424 -88.600  9.477   1.00 90.42  ? 50  ALA B CA  1 
ATOM 3955 C C   . ALA B 1 52  ? 73.227 -89.842  9.085   1.00 87.84  ? 50  ALA B C   1 
ATOM 3956 O O   . ALA B 1 52  ? 74.434 -89.898  9.337   1.00 96.86  ? 50  ALA B O   1 
ATOM 3957 C CB  . ALA B 1 52  ? 71.674 -88.809  10.781  1.00 96.30  ? 50  ALA B CB  1 
ATOM 3958 N N   . MET B 1 53  ? 72.565 -90.834  8.471   1.00 81.00  ? 51  MET B N   1 
ATOM 3959 C CA  . MET B 1 53  ? 73.264 -92.023  8.004   1.00 73.48  ? 51  MET B CA  1 
ATOM 3960 C C   . MET B 1 53  ? 74.376 -91.635  7.029   1.00 74.83  ? 51  MET B C   1 
ATOM 3961 O O   . MET B 1 53  ? 75.446 -92.231  7.040   1.00 87.52  ? 51  MET B O   1 
ATOM 3962 C CB  . MET B 1 53  ? 72.315 -93.009  7.319   1.00 66.78  ? 51  MET B CB  1 
ATOM 3963 C CG  . MET B 1 53  ? 71.241 -93.537  8.222   1.00 67.66  ? 51  MET B CG  1 
ATOM 3964 S SD  . MET B 1 53  ? 70.366 -94.868  7.384   1.00 83.34  ? 51  MET B SD  1 
ATOM 3965 C CE  . MET B 1 53  ? 68.809 -95.037  8.267   1.00 79.81  ? 51  MET B CE  1 
ATOM 3966 N N   . VAL B 1 54  ? 74.132 -90.619  6.204   1.00 77.33  ? 52  VAL B N   1 
ATOM 3967 C CA  . VAL B 1 54  ? 75.080 -90.245  5.176   1.00 84.89  ? 52  VAL B CA  1 
ATOM 3968 C C   . VAL B 1 54  ? 76.288 -89.566  5.800   1.00 90.47  ? 52  VAL B C   1 
ATOM 3969 O O   . VAL B 1 54  ? 77.415 -89.917  5.463   1.00 120.60 ? 52  VAL B O   1 
ATOM 3970 C CB  . VAL B 1 54  ? 74.427 -89.353  4.110   1.00 99.61  ? 52  VAL B CB  1 
ATOM 3971 C CG1 . VAL B 1 54  ? 75.468 -88.666  3.228   1.00 97.06  ? 52  VAL B CG1 1 
ATOM 3972 C CG2 . VAL B 1 54  ? 73.442 -90.154  3.268   1.00 111.59 ? 52  VAL B CG2 1 
ATOM 3973 N N   . LYS B 1 55  ? 76.050 -88.585  6.676   1.00 90.22  ? 53  LYS B N   1 
ATOM 3974 C CA  . LYS B 1 55  ? 77.130 -87.799  7.258   1.00 96.82  ? 53  LYS B CA  1 
ATOM 3975 C C   . LYS B 1 55  ? 78.061 -88.693  8.077   1.00 95.79  ? 53  LYS B C   1 
ATOM 3976 O O   . LYS B 1 55  ? 79.269 -88.423  8.162   1.00 85.21  ? 53  LYS B O   1 
ATOM 3977 C CB  . LYS B 1 55  ? 76.558 -86.666  8.114   1.00 100.36 ? 53  LYS B CB  1 
ATOM 3978 C CG  . LYS B 1 55  ? 75.787 -85.617  7.324   1.00 103.83 ? 53  LYS B CG  1 
ATOM 3979 C CD  . LYS B 1 55  ? 76.629 -84.911  6.264   1.00 108.97 ? 53  LYS B CD  1 
ATOM 3980 C CE  . LYS B 1 55  ? 75.850 -83.911  5.474   1.00 111.79 ? 53  LYS B CE  1 
ATOM 3981 N NZ  . LYS B 1 55  ? 76.694 -83.139  4.560   1.00 103.80 ? 53  LYS B NZ  1 
ATOM 3982 N N   . LYS B 1 56  ? 77.461 -89.745  8.661   1.00 87.87  ? 54  LYS B N   1 
ATOM 3983 C CA  . LYS B 1 56  ? 78.164 -90.782  9.399   1.00 82.14  ? 54  LYS B CA  1 
ATOM 3984 C C   . LYS B 1 56  ? 79.070 -91.577  8.464   1.00 72.80  ? 54  LYS B C   1 
ATOM 3985 O O   . LYS B 1 56  ? 80.280 -91.601  8.659   1.00 81.42  ? 54  LYS B O   1 
ATOM 3986 C CB  . LYS B 1 56  ? 77.161 -91.692  10.122  1.00 90.31  ? 54  LYS B CB  1 
ATOM 3987 C CG  . LYS B 1 56  ? 77.736 -93.012  10.646  1.00 93.22  ? 54  LYS B CG  1 
ATOM 3988 C CD  . LYS B 1 56  ? 76.776 -93.825  11.504  1.00 90.26  ? 54  LYS B CD  1 
ATOM 3989 C CE  . LYS B 1 56  ? 77.291 -95.191  11.773  1.00 84.52  ? 54  LYS B CE  1 
ATOM 3990 N NZ  . LYS B 1 56  ? 76.394 -95.801  12.758  1.00 83.57  ? 54  LYS B NZ  1 
ATOM 3991 N N   . ALA B 1 57  ? 78.488 -92.231  7.455   1.00 68.30  ? 55  ALA B N   1 
ATOM 3992 C CA  . ALA B 1 57  ? 79.285 -92.936  6.462   1.00 71.57  ? 55  ALA B CA  1 
ATOM 3993 C C   . ALA B 1 57  ? 80.390 -92.027  5.921   1.00 81.81  ? 55  ALA B C   1 
ATOM 3994 O O   . ALA B 1 57  ? 81.477 -92.503  5.600   1.00 98.07  ? 55  ALA B O   1 
ATOM 3995 C CB  . ALA B 1 57  ? 78.418 -93.449  5.340   1.00 67.70  ? 55  ALA B CB  1 
ATOM 3996 N N   . ALA B 1 58  ? 80.111 -90.722  5.826   1.00 82.37  ? 56  ALA B N   1 
ATOM 3997 C CA  . ALA B 1 58  ? 81.059 -89.774  5.267   1.00 89.05  ? 56  ALA B CA  1 
ATOM 3998 C C   . ALA B 1 58  ? 82.196 -89.525  6.250   1.00 96.98  ? 56  ALA B C   1 
ATOM 3999 O O   . ALA B 1 58  ? 83.363 -89.577  5.868   1.00 105.63 ? 56  ALA B O   1 
ATOM 4000 C CB  . ALA B 1 58  ? 80.356 -88.490  4.910   1.00 98.92  ? 56  ALA B CB  1 
ATOM 4001 N N   . ALA B 1 59  ? 81.850 -89.237  7.507   1.00 99.39  ? 57  ALA B N   1 
ATOM 4002 C CA  . ALA B 1 59  ? 82.849 -89.184  8.561   1.00 103.31 ? 57  ALA B CA  1 
ATOM 4003 C C   . ALA B 1 59  ? 83.687 -90.468  8.556   1.00 93.26  ? 57  ALA B C   1 
ATOM 4004 O O   . ALA B 1 59  ? 84.896 -90.407  8.352   1.00 97.43  ? 57  ALA B O   1 
ATOM 4005 C CB  . ALA B 1 59  ? 82.182 -88.942  9.898   1.00 103.60 ? 57  ALA B CB  1 
ATOM 4006 N N   . LEU B 1 60  ? 83.038 -91.626  8.731   1.00 85.02  ? 58  LEU B N   1 
ATOM 4007 C CA  . LEU B 1 60  ? 83.723 -92.912  8.775   1.00 89.87  ? 58  LEU B CA  1 
ATOM 4008 C C   . LEU B 1 60  ? 84.720 -93.040  7.629   1.00 93.47  ? 58  LEU B C   1 
ATOM 4009 O O   . LEU B 1 60  ? 85.836 -93.507  7.835   1.00 99.87  ? 58  LEU B O   1 
ATOM 4010 C CB  . LEU B 1 60  ? 82.749 -94.083  8.716   1.00 92.21  ? 58  LEU B CB  1 
ATOM 4011 C CG  . LEU B 1 60  ? 81.946 -94.362  9.988   1.00 101.81 ? 58  LEU B CG  1 
ATOM 4012 C CD1 . LEU B 1 60  ? 80.980 -95.501  9.708   1.00 103.49 ? 58  LEU B CD1 1 
ATOM 4013 C CD2 . LEU B 1 60  ? 82.834 -94.692  11.175  1.00 103.53 ? 58  LEU B CD2 1 
ATOM 4014 N N   . ALA B 1 61  ? 84.296 -92.667  6.422   1.00 96.75  ? 59  ALA B N   1 
ATOM 4015 C CA  . ALA B 1 61  ? 85.139 -92.819  5.245   1.00 111.85 ? 59  ALA B CA  1 
ATOM 4016 C C   . ALA B 1 61  ? 86.311 -91.836  5.276   1.00 103.83 ? 59  ALA B C   1 
ATOM 4017 O O   . ALA B 1 61  ? 87.405 -92.154  4.811   1.00 95.70  ? 59  ALA B O   1 
ATOM 4018 C CB  . ALA B 1 61  ? 84.310 -92.655  3.986   1.00 120.35 ? 59  ALA B CB  1 
ATOM 4019 N N   . ASN B 1 62  ? 86.080 -90.639  5.824   1.00 96.03  ? 60  ASN B N   1 
ATOM 4020 C CA  . ASN B 1 62  ? 87.103 -89.605  5.849   1.00 104.53 ? 60  ASN B CA  1 
ATOM 4021 C C   . ASN B 1 62  ? 88.154 -89.904  6.923   1.00 107.76 ? 60  ASN B C   1 
ATOM 4022 O O   . ASN B 1 62  ? 89.273 -89.396  6.850   1.00 105.64 ? 60  ASN B O   1 
ATOM 4023 C CB  . ASN B 1 62  ? 86.503 -88.218  6.058   1.00 115.45 ? 60  ASN B CB  1 
ATOM 4024 C CG  . ASN B 1 62  ? 85.725 -87.711  4.863   1.00 108.36 ? 60  ASN B CG  1 
ATOM 4025 O OD1 . ASN B 1 62  ? 86.250 -87.644  3.745   1.00 98.67  ? 60  ASN B OD1 1 
ATOM 4026 N ND2 . ASN B 1 62  ? 84.482 -87.314  5.085   1.00 112.01 ? 60  ASN B ND2 1 
ATOM 4027 N N   . MET B 1 63  ? 87.786 -90.699  7.938   1.00 112.08 ? 61  MET B N   1 
ATOM 4028 C CA  . MET B 1 63  ? 88.745 -91.189  8.920   1.00 100.26 ? 61  MET B CA  1 
ATOM 4029 C C   . MET B 1 63  ? 89.547 -92.336  8.299   1.00 93.42  ? 61  MET B C   1 
ATOM 4030 O O   . MET B 1 63  ? 90.769 -92.309  8.346   1.00 94.78  ? 61  MET B O   1 
ATOM 4031 C CB  . MET B 1 63  ? 88.054 -91.597  10.229  1.00 96.67  ? 61  MET B CB  1 
ATOM 4032 C CG  . MET B 1 63  ? 87.495 -90.406  11.007  1.00 98.02  ? 61  MET B CG  1 
ATOM 4033 S SD  . MET B 1 63  ? 86.756 -90.754  12.617  1.00 106.46 ? 61  MET B SD  1 
ATOM 4034 C CE  . MET B 1 63  ? 85.856 -92.285  12.325  1.00 111.78 ? 61  MET B CE  1 
ATOM 4035 N N   . GLU B 1 64  ? 88.869 -93.299  7.655   1.00 88.42  ? 62  GLU B N   1 
ATOM 4036 C CA  . GLU B 1 64  ? 89.525 -94.413  6.977   1.00 85.79  ? 62  GLU B CA  1 
ATOM 4037 C C   . GLU B 1 64  ? 90.588 -93.960  5.979   1.00 85.96  ? 62  GLU B C   1 
ATOM 4038 O O   . GLU B 1 64  ? 91.519 -94.708  5.709   1.00 89.73  ? 62  GLU B O   1 
ATOM 4039 C CB  . GLU B 1 64  ? 88.560 -95.286  6.175   1.00 87.70  ? 62  GLU B CB  1 
ATOM 4040 C CG  . GLU B 1 64  ? 88.327 -96.665  6.778   1.00 95.20  ? 62  GLU B CG  1 
ATOM 4041 C CD  . GLU B 1 64  ? 87.211 -97.403  6.070   1.00 109.94 ? 62  GLU B CD  1 
ATOM 4042 O OE1 . GLU B 1 64  ? 86.038 -97.062  6.327   1.00 126.37 ? 62  GLU B OE1 1 
ATOM 4043 O OE2 . GLU B 1 64  ? 87.506 -98.288  5.239   1.00 116.24 ? 62  GLU B OE2 1 
ATOM 4044 N N   . THR B 1 65  ? 90.430 -92.773  5.388   1.00 93.87  ? 63  THR B N   1 
ATOM 4045 C CA  . THR B 1 65  ? 91.405 -92.269  4.434   1.00 95.57  ? 63  THR B CA  1 
ATOM 4046 C C   . THR B 1 65  ? 92.282 -91.209  5.100   1.00 88.76  ? 63  THR B C   1 
ATOM 4047 O O   . THR B 1 65  ? 92.960 -90.440  4.422   1.00 79.53  ? 63  THR B O   1 
ATOM 4048 C CB  . THR B 1 65  ? 90.673 -91.751  3.196   1.00 102.19 ? 63  THR B CB  1 
ATOM 4049 O OG1 . THR B 1 65  ? 89.848 -90.664  3.600   1.00 102.14 ? 63  THR B OG1 1 
ATOM 4050 C CG2 . THR B 1 65  ? 89.832 -92.839  2.555   1.00 101.38 ? 63  THR B CG2 1 
ATOM 4051 N N   . LYS B 1 66  ? 92.249 -91.178  6.435   1.00 89.11  ? 64  LYS B N   1 
ATOM 4052 C CA  . LYS B 1 66  ? 93.178 -90.405  7.241   1.00 100.95 ? 64  LYS B CA  1 
ATOM 4053 C C   . LYS B 1 66  ? 93.247 -88.965  6.744   1.00 103.46 ? 64  LYS B C   1 
ATOM 4054 O O   . LYS B 1 66  ? 94.322 -88.380  6.619   1.00 101.88 ? 64  LYS B O   1 
ATOM 4055 C CB  . LYS B 1 66  ? 94.522 -91.133  7.251   1.00 117.75 ? 64  LYS B CB  1 
ATOM 4056 C CG  . LYS B 1 66  ? 94.434 -92.578  7.765   1.00 123.78 ? 64  LYS B CG  1 
ATOM 4057 C CD  . LYS B 1 66  ? 95.516 -93.019  8.751   1.00 126.03 ? 64  LYS B CD  1 
ATOM 4058 C CE  . LYS B 1 66  ? 95.401 -92.419  10.132  1.00 111.76 ? 64  LYS B CE  1 
ATOM 4059 N NZ  . LYS B 1 66  ? 96.485 -92.885  11.001  1.00 102.47 ? 64  LYS B NZ  1 
ATOM 4060 N N   . ARG B 1 67  ? 92.070 -88.407  6.454   1.00 109.20 ? 65  ARG B N   1 
ATOM 4061 C CA  . ARG B 1 67  ? 91.959 -86.999  6.105   1.00 107.66 ? 65  ARG B CA  1 
ATOM 4062 C C   . ARG B 1 67  ? 91.130 -86.270  7.164   1.00 98.34  ? 65  ARG B C   1 
ATOM 4063 O O   . ARG B 1 67  ? 91.364 -85.092  7.401   1.00 88.62  ? 65  ARG B O   1 
ATOM 4064 C CB  . ARG B 1 67  ? 91.516 -86.798  4.646   1.00 117.18 ? 65  ARG B CB  1 
ATOM 4065 C CG  . ARG B 1 67  ? 90.358 -87.625  4.100   1.00 120.40 ? 65  ARG B CG  1 
ATOM 4066 C CD  . ARG B 1 67  ? 90.203 -87.530  2.571   1.00 124.31 ? 65  ARG B CD  1 
ATOM 4067 N NE  . ARG B 1 67  ? 90.018 -86.143  2.117   1.00 132.05 ? 65  ARG B NE  1 
ATOM 4068 C CZ  . ARG B 1 67  ? 89.255 -85.706  1.111   1.00 121.97 ? 65  ARG B CZ  1 
ATOM 4069 N NH1 . ARG B 1 67  ? 88.674 -86.576  0.296   1.00 127.24 ? 65  ARG B NH1 1 
ATOM 4070 N NH2 . ARG B 1 67  ? 89.118 -84.399  0.917   1.00 99.30  ? 65  ARG B NH2 1 
ATOM 4071 N N   . LEU B 1 68  ? 90.188 -86.961  7.820   1.00 104.97 ? 66  LEU B N   1 
ATOM 4072 C CA  . LEU B 1 68  ? 89.465 -86.379  8.941   1.00 110.81 ? 66  LEU B CA  1 
ATOM 4073 C C   . LEU B 1 68  ? 90.056 -86.915  10.244  1.00 114.31 ? 66  LEU B C   1 
ATOM 4074 O O   . LEU B 1 68  ? 90.084 -88.134  10.434  1.00 115.69 ? 66  LEU B O   1 
ATOM 4075 C CB  . LEU B 1 68  ? 87.967 -86.686  8.866   1.00 110.43 ? 66  LEU B CB  1 
ATOM 4076 C CG  . LEU B 1 68  ? 87.096 -86.141  10.011  1.00 114.37 ? 66  LEU B CG  1 
ATOM 4077 C CD1 . LEU B 1 68  ? 86.874 -84.643  9.906   1.00 114.63 ? 66  LEU B CD1 1 
ATOM 4078 C CD2 . LEU B 1 68  ? 85.757 -86.849  10.109  1.00 120.69 ? 66  LEU B CD2 1 
ATOM 4079 N N   . PRO B 1 69  ? 90.492 -86.032  11.183  1.00 100.53 ? 67  PRO B N   1 
ATOM 4080 C CA  . PRO B 1 69  ? 90.911 -86.452  12.527  1.00 97.89  ? 67  PRO B CA  1 
ATOM 4081 C C   . PRO B 1 69  ? 89.882 -87.286  13.288  1.00 98.23  ? 67  PRO B C   1 
ATOM 4082 O O   . PRO B 1 69  ? 88.746 -86.856  13.444  1.00 118.80 ? 67  PRO B O   1 
ATOM 4083 C CB  . PRO B 1 69  ? 91.151 -85.100  13.233  1.00 94.03  ? 67  PRO B CB  1 
ATOM 4084 C CG  . PRO B 1 69  ? 90.311 -84.126  12.448  1.00 90.30  ? 67  PRO B CG  1 
ATOM 4085 C CD  . PRO B 1 69  ? 90.575 -84.570  11.018  1.00 91.35  ? 67  PRO B CD  1 
ATOM 4086 N N   . ALA B 1 70  ? 90.301 -88.446  13.812  1.00 98.01  ? 68  ALA B N   1 
ATOM 4087 C CA  . ALA B 1 70  ? 89.415 -89.332  14.561  1.00 100.33 ? 68  ALA B CA  1 
ATOM 4088 C C   . ALA B 1 70  ? 88.803 -88.627  15.780  1.00 98.47  ? 68  ALA B C   1 
ATOM 4089 O O   . ALA B 1 70  ? 87.704 -88.978  16.217  1.00 90.14  ? 68  ALA B O   1 
ATOM 4090 C CB  . ALA B 1 70  ? 90.169 -90.590  14.952  1.00 99.92  ? 68  ALA B CB  1 
ATOM 4091 N N   . HIS B 1 71  ? 89.533 -87.639  16.324  1.00 107.59 ? 69  HIS B N   1 
ATOM 4092 C CA  . HIS B 1 71  ? 89.075 -86.695  17.339  1.00 118.65 ? 69  HIS B CA  1 
ATOM 4093 C C   . HIS B 1 71  ? 87.664 -86.176  17.027  1.00 130.05 ? 69  HIS B C   1 
ATOM 4094 O O   . HIS B 1 71  ? 86.744 -86.253  17.847  1.00 126.11 ? 69  HIS B O   1 
ATOM 4095 C CB  . HIS B 1 71  ? 90.098 -85.548  17.365  1.00 123.30 ? 69  HIS B CB  1 
ATOM 4096 C CG  . HIS B 1 71  ? 89.861 -84.398  18.289  1.00 135.40 ? 69  HIS B CG  1 
ATOM 4097 N ND1 . HIS B 1 71  ? 89.866 -84.464  19.669  1.00 151.59 ? 69  HIS B ND1 1 
ATOM 4098 C CD2 . HIS B 1 71  ? 89.734 -83.100  17.988  1.00 135.20 ? 69  HIS B CD2 1 
ATOM 4099 C CE1 . HIS B 1 71  ? 89.686 -83.251  20.172  1.00 147.29 ? 69  HIS B CE1 1 
ATOM 4100 N NE2 . HIS B 1 71  ? 89.604 -82.404  19.170  1.00 152.35 ? 69  HIS B NE2 1 
ATOM 4101 N N   . ILE B 1 72  ? 87.511 -85.650  15.808  1.00 132.36 ? 70  ILE B N   1 
ATOM 4102 C CA  . ILE B 1 72  ? 86.311 -84.933  15.401  1.00 110.30 ? 70  ILE B CA  1 
ATOM 4103 C C   . ILE B 1 72  ? 85.295 -85.942  14.871  1.00 93.55  ? 70  ILE B C   1 
ATOM 4104 O O   . ILE B 1 72  ? 84.139 -85.923  15.270  1.00 84.66  ? 70  ILE B O   1 
ATOM 4105 C CB  . ILE B 1 72  ? 86.653 -83.861  14.344  1.00 114.37 ? 70  ILE B CB  1 
ATOM 4106 C CG1 . ILE B 1 72  ? 87.724 -82.872  14.826  1.00 119.62 ? 70  ILE B CG1 1 
ATOM 4107 C CG2 . ILE B 1 72  ? 85.395 -83.128  13.885  1.00 117.70 ? 70  ILE B CG2 1 
ATOM 4108 C CD1 . ILE B 1 72  ? 87.296 -81.996  15.991  1.00 123.90 ? 70  ILE B CD1 1 
ATOM 4109 N N   . GLY B 1 73  ? 85.753 -86.818  13.971  1.00 84.90  ? 71  GLY B N   1 
ATOM 4110 C CA  . GLY B 1 73  ? 84.908 -87.779  13.285  1.00 84.19  ? 71  GLY B CA  1 
ATOM 4111 C C   . GLY B 1 73  ? 84.080 -88.640  14.238  1.00 91.35  ? 71  GLY B C   1 
ATOM 4112 O O   . GLY B 1 73  ? 82.910 -88.897  13.970  1.00 100.29 ? 71  GLY B O   1 
ATOM 4113 N N   . GLU B 1 74  ? 84.668 -89.088  15.349  1.00 95.68  ? 72  GLU B N   1 
ATOM 4114 C CA  . GLU B 1 74  ? 83.950 -89.979  16.248  1.00 92.99  ? 72  GLU B CA  1 
ATOM 4115 C C   . GLU B 1 74  ? 82.854 -89.194  16.973  1.00 94.27  ? 72  GLU B C   1 
ATOM 4116 O O   . GLU B 1 74  ? 81.784 -89.734  17.270  1.00 70.04  ? 72  GLU B O   1 
ATOM 4117 C CB  . GLU B 1 74  ? 84.918 -90.751  17.151  1.00 102.68 ? 72  GLU B CB  1 
ATOM 4118 C CG  . GLU B 1 74  ? 85.663 -91.859  16.408  1.00 119.05 ? 72  GLU B CG  1 
ATOM 4119 C CD  . GLU B 1 74  ? 86.122 -93.040  17.242  1.00 127.30 ? 72  GLU B CD  1 
ATOM 4120 O OE1 . GLU B 1 74  ? 85.222 -93.808  17.632  1.00 128.93 ? 72  GLU B OE1 1 
ATOM 4121 O OE2 . GLU B 1 74  ? 87.337 -93.192  17.492  1.00 133.56 ? 72  GLU B OE2 1 
ATOM 4122 N N   . ALA B 1 75  ? 83.106 -87.899  17.215  1.00 104.72 ? 73  ALA B N   1 
ATOM 4123 C CA  . ALA B 1 75  ? 82.121 -87.026  17.843  1.00 105.64 ? 73  ALA B CA  1 
ATOM 4124 C C   . ALA B 1 75  ? 80.935 -86.822  16.911  1.00 100.28 ? 73  ALA B C   1 
ATOM 4125 O O   . ALA B 1 75  ? 79.791 -86.771  17.348  1.00 90.90  ? 73  ALA B O   1 
ATOM 4126 C CB  . ALA B 1 75  ? 82.744 -85.695  18.197  1.00 104.70 ? 73  ALA B CB  1 
ATOM 4127 N N   . ILE B 1 76  ? 81.257 -86.653  15.629  1.00 97.41  ? 74  ILE B N   1 
ATOM 4128 C CA  . ILE B 1 76  ? 80.275 -86.566  14.564  1.00 90.73  ? 74  ILE B CA  1 
ATOM 4129 C C   . ILE B 1 76  ? 79.479 -87.868  14.499  1.00 84.10  ? 74  ILE B C   1 
ATOM 4130 O O   . ILE B 1 76  ? 78.257 -87.844  14.628  1.00 81.24  ? 74  ILE B O   1 
ATOM 4131 C CB  . ILE B 1 76  ? 80.995 -86.220  13.250  1.00 84.24  ? 74  ILE B CB  1 
ATOM 4132 C CG1 . ILE B 1 76  ? 81.487 -84.760  13.290  1.00 75.63  ? 74  ILE B CG1 1 
ATOM 4133 C CG2 . ILE B 1 76  ? 80.117 -86.517  12.033  1.00 88.56  ? 74  ILE B CG2 1 
ATOM 4134 C CD1 . ILE B 1 76  ? 82.450 -84.385  12.185  1.00 72.06  ? 74  ILE B CD1 1 
ATOM 4135 N N   . VAL B 1 77  ? 80.186 -88.994  14.337  1.00 81.39  ? 75  VAL B N   1 
ATOM 4136 C CA  . VAL B 1 77  ? 79.556 -90.307  14.285  1.00 87.96  ? 75  VAL B CA  1 
ATOM 4137 C C   . VAL B 1 77  ? 78.621 -90.478  15.484  1.00 94.11  ? 75  VAL B C   1 
ATOM 4138 O O   . VAL B 1 77  ? 77.535 -91.050  15.364  1.00 87.49  ? 75  VAL B O   1 
ATOM 4139 C CB  . VAL B 1 77  ? 80.559 -91.477  14.228  1.00 79.77  ? 75  VAL B CB  1 
ATOM 4140 C CG1 . VAL B 1 77  ? 79.849 -92.818  14.398  1.00 78.55  ? 75  VAL B CG1 1 
ATOM 4141 C CG2 . VAL B 1 77  ? 81.382 -91.485  12.945  1.00 74.89  ? 75  VAL B CG2 1 
ATOM 4142 N N   . ALA B 1 78  ? 79.068 -90.012  16.651  1.00 95.33  ? 76  ALA B N   1 
ATOM 4143 C CA  . ALA B 1 78  ? 78.271 -90.139  17.856  1.00 104.19 ? 76  ALA B CA  1 
ATOM 4144 C C   . ALA B 1 78  ? 76.969 -89.359  17.706  1.00 106.64 ? 76  ALA B C   1 
ATOM 4145 O O   . ALA B 1 78  ? 75.901 -89.832  18.102  1.00 96.08  ? 76  ALA B O   1 
ATOM 4146 C CB  . ALA B 1 78  ? 79.074 -89.649  19.033  1.00 108.87 ? 76  ALA B CB  1 
ATOM 4147 N N   . ALA B 1 79  ? 77.087 -88.149  17.143  1.00 115.40 ? 77  ALA B N   1 
ATOM 4148 C CA  . ALA B 1 79  ? 75.967 -87.233  17.007  1.00 112.57 ? 77  ALA B CA  1 
ATOM 4149 C C   . ALA B 1 79  ? 74.994 -87.787  15.971  1.00 100.62 ? 77  ALA B C   1 
ATOM 4150 O O   . ALA B 1 79  ? 73.786 -87.802  16.195  1.00 97.54  ? 77  ALA B O   1 
ATOM 4151 C CB  . ALA B 1 79  ? 76.466 -85.846  16.635  1.00 103.08 ? 77  ALA B CB  1 
ATOM 4152 N N   . CYS B 1 80  ? 75.545 -88.253  14.846  1.00 87.61  ? 78  CYS B N   1 
ATOM 4153 C CA  . CYS B 1 80  ? 74.750 -88.917  13.830  1.00 92.56  ? 78  CYS B CA  1 
ATOM 4154 C C   . CYS B 1 80  ? 73.902 -90.014  14.464  1.00 95.82  ? 78  CYS B C   1 
ATOM 4155 O O   . CYS B 1 80  ? 72.683 -90.035  14.290  1.00 93.27  ? 78  CYS B O   1 
ATOM 4156 C CB  . CYS B 1 80  ? 75.629 -89.489  12.723  1.00 87.46  ? 78  CYS B CB  1 
ATOM 4157 S SG  . CYS B 1 80  ? 76.388 -88.201  11.696  1.00 85.00  ? 78  CYS B SG  1 
ATOM 4158 N N   . ASP B 1 81  ? 74.566 -90.892  15.223  1.00 98.74  ? 79  ASP B N   1 
ATOM 4159 C CA  . ASP B 1 81  ? 73.937 -92.090  15.754  1.00 104.69 ? 79  ASP B CA  1 
ATOM 4160 C C   . ASP B 1 81  ? 72.708 -91.724  16.582  1.00 104.80 ? 79  ASP B C   1 
ATOM 4161 O O   . ASP B 1 81  ? 71.739 -92.482  16.606  1.00 97.00  ? 79  ASP B O   1 
ATOM 4162 C CB  . ASP B 1 81  ? 74.938 -92.961  16.502  1.00 107.46 ? 79  ASP B CB  1 
ATOM 4163 C CG  . ASP B 1 81  ? 75.646 -94.004  15.644  1.00 108.32 ? 79  ASP B CG  1 
ATOM 4164 O OD1 . ASP B 1 81  ? 74.926 -94.816  15.019  1.00 99.56  ? 79  ASP B OD1 1 
ATOM 4165 O OD2 . ASP B 1 81  ? 76.903 -93.996  15.595  1.00 104.13 ? 79  ASP B OD2 1 
ATOM 4166 N N   . GLU B 1 82  ? 72.756 -90.559  17.241  1.00 103.70 ? 80  GLU B N   1 
ATOM 4167 C CA  . GLU B 1 82  ? 71.651 -90.093  18.067  1.00 107.64 ? 80  GLU B CA  1 
ATOM 4168 C C   . GLU B 1 82  ? 70.488 -89.599  17.205  1.00 109.78 ? 80  GLU B C   1 
ATOM 4169 O O   . GLU B 1 82  ? 69.322 -89.877  17.498  1.00 101.74 ? 80  GLU B O   1 
ATOM 4170 C CB  . GLU B 1 82  ? 72.115 -88.968  18.993  1.00 115.26 ? 80  GLU B CB  1 
ATOM 4171 C CG  . GLU B 1 82  ? 73.019 -89.455  20.121  1.00 113.00 ? 80  GLU B CG  1 
ATOM 4172 C CD  . GLU B 1 82  ? 73.568 -88.369  21.022  1.00 103.59 ? 80  GLU B CD  1 
ATOM 4173 O OE1 . GLU B 1 82  ? 73.479 -87.157  20.716  1.00 106.53 ? 80  GLU B OE1 1 
ATOM 4174 O OE2 . GLU B 1 82  ? 74.103 -88.779  22.068  1.00 91.69  ? 80  GLU B OE2 1 
ATOM 4175 N N   . ILE B 1 83  ? 70.822 -88.848  16.149  1.00 106.93 ? 81  ILE B N   1 
ATOM 4176 C CA  . ILE B 1 83  ? 69.822 -88.347  15.225  1.00 90.58  ? 81  ILE B CA  1 
ATOM 4177 C C   . ILE B 1 83  ? 69.164 -89.552  14.550  1.00 88.61  ? 81  ILE B C   1 
ATOM 4178 O O   . ILE B 1 83  ? 67.944 -89.583  14.408  1.00 90.29  ? 81  ILE B O   1 
ATOM 4179 C CB  . ILE B 1 83  ? 70.445 -87.365  14.216  1.00 81.54  ? 81  ILE B CB  1 
ATOM 4180 C CG1 . ILE B 1 83  ? 71.145 -86.190  14.912  1.00 79.11  ? 81  ILE B CG1 1 
ATOM 4181 C CG2 . ILE B 1 83  ? 69.383 -86.867  13.240  1.00 78.47  ? 81  ILE B CG2 1 
ATOM 4182 C CD1 . ILE B 1 83  ? 71.948 -85.284  13.990  1.00 74.01  ? 81  ILE B CD1 1 
ATOM 4183 N N   . ILE B 1 84  ? 69.976 -90.555  14.172  1.00 75.30  ? 82  ILE B N   1 
ATOM 4184 C CA  . ILE B 1 84  ? 69.481 -91.815  13.629  1.00 73.70  ? 82  ILE B CA  1 
ATOM 4185 C C   . ILE B 1 84  ? 68.495 -92.470  14.590  1.00 84.90  ? 82  ILE B C   1 
ATOM 4186 O O   . ILE B 1 84  ? 67.495 -93.052  14.163  1.00 85.79  ? 82  ILE B O   1 
ATOM 4187 C CB  . ILE B 1 84  ? 70.637 -92.780  13.323  1.00 74.43  ? 82  ILE B CB  1 
ATOM 4188 C CG1 . ILE B 1 84  ? 71.500 -92.265  12.170  1.00 83.93  ? 82  ILE B CG1 1 
ATOM 4189 C CG2 . ILE B 1 84  ? 70.102 -94.189  13.050  1.00 72.89  ? 82  ILE B CG2 1 
ATOM 4190 C CD1 . ILE B 1 84  ? 72.741 -93.100  11.890  1.00 94.90  ? 82  ILE B CD1 1 
ATOM 4191 N N   . ALA B 1 85  ? 68.835 -92.419  15.884  1.00 103.38 ? 83  ALA B N   1 
ATOM 4192 C CA  . ALA B 1 85  ? 68.028 -93.017  16.936  1.00 107.80 ? 83  ALA B CA  1 
ATOM 4193 C C   . ALA B 1 85  ? 66.753 -92.207  17.134  1.00 105.14 ? 83  ALA B C   1 
ATOM 4194 O O   . ALA B 1 85  ? 65.750 -92.734  17.602  1.00 104.02 ? 83  ALA B O   1 
ATOM 4195 C CB  . ALA B 1 85  ? 68.831 -93.100  18.210  1.00 104.28 ? 83  ALA B CB  1 
ATOM 4196 N N   . GLY B 1 86  ? 66.814 -90.923  16.774  1.00 103.35 ? 84  GLY B N   1 
ATOM 4197 C CA  . GLY B 1 86  ? 65.627 -90.097  16.669  1.00 101.79 ? 84  GLY B CA  1 
ATOM 4198 C C   . GLY B 1 86  ? 65.658 -88.942  17.659  1.00 93.81  ? 84  GLY B C   1 
ATOM 4199 O O   . GLY B 1 86  ? 64.603 -88.460  18.061  1.00 82.46  ? 84  GLY B O   1 
ATOM 4200 N N   . GLN B 1 87  ? 66.863 -88.464  17.986  1.00 95.57  ? 85  GLN B N   1 
ATOM 4201 C CA  . GLN B 1 87  ? 66.985 -87.448  19.009  1.00 112.84 ? 85  GLN B CA  1 
ATOM 4202 C C   . GLN B 1 87  ? 66.632 -86.100  18.394  1.00 117.84 ? 85  GLN B C   1 
ATOM 4203 O O   . GLN B 1 87  ? 65.547 -85.571  18.636  1.00 147.97 ? 85  GLN B O   1 
ATOM 4204 C CB  . GLN B 1 87  ? 68.326 -87.535  19.746  1.00 126.47 ? 85  GLN B CB  1 
ATOM 4205 C CG  . GLN B 1 87  ? 68.330 -88.574  20.867  1.00 135.06 ? 85  GLN B CG  1 
ATOM 4206 C CD  . GLN B 1 87  ? 69.501 -88.489  21.829  1.00 132.24 ? 85  GLN B CD  1 
ATOM 4207 O OE1 . GLN B 1 87  ? 70.479 -87.771  21.623  1.00 134.86 ? 85  GLN B OE1 1 
ATOM 4208 N NE2 . GLN B 1 87  ? 69.367 -89.187  22.947  1.00 126.49 ? 85  GLN B NE2 1 
ATOM 4209 N N   . TRP B 1 88  ? 67.502 -85.570  17.545  1.00 99.01  ? 86  TRP B N   1 
ATOM 4210 C CA  . TRP B 1 88  ? 67.553 -84.123  17.422  1.00 101.17 ? 86  TRP B CA  1 
ATOM 4211 C C   . TRP B 1 88  ? 66.683 -83.596  16.284  1.00 99.50  ? 86  TRP B C   1 
ATOM 4212 O O   . TRP B 1 88  ? 66.988 -82.550  15.712  1.00 93.54  ? 86  TRP B O   1 
ATOM 4213 C CB  . TRP B 1 88  ? 69.019 -83.712  17.287  1.00 109.08 ? 86  TRP B CB  1 
ATOM 4214 C CG  . TRP B 1 88  ? 69.822 -84.263  18.432  1.00 111.90 ? 86  TRP B CG  1 
ATOM 4215 C CD1 . TRP B 1 88  ? 70.649 -85.349  18.439  1.00 115.22 ? 86  TRP B CD1 1 
ATOM 4216 C CD2 . TRP B 1 88  ? 69.777 -83.783  19.788  1.00 104.81 ? 86  TRP B CD2 1 
ATOM 4217 N NE1 . TRP B 1 88  ? 71.174 -85.539  19.689  1.00 108.66 ? 86  TRP B NE1 1 
ATOM 4218 C CE2 . TRP B 1 88  ? 70.648 -84.603  20.539  1.00 101.62 ? 86  TRP B CE2 1 
ATOM 4219 C CE3 . TRP B 1 88  ? 69.096 -82.741  20.423  1.00 93.75  ? 86  TRP B CE3 1 
ATOM 4220 C CZ2 . TRP B 1 88  ? 70.850 -84.411  21.900  1.00 82.37  ? 86  TRP B CZ2 1 
ATOM 4221 C CZ3 . TRP B 1 88  ? 69.299 -82.554  21.770  1.00 84.56  ? 86  TRP B CZ3 1 
ATOM 4222 C CH2 . TRP B 1 88  ? 70.149 -83.391  22.496  1.00 79.30  ? 86  TRP B CH2 1 
ATOM 4223 N N   . HIS B 1 89  ? 65.560 -84.277  16.018  1.00 96.28  ? 87  HIS B N   1 
ATOM 4224 C CA  . HIS B 1 89  ? 64.726 -83.979  14.865  1.00 85.64  ? 87  HIS B CA  1 
ATOM 4225 C C   . HIS B 1 89  ? 64.197 -82.548  14.942  1.00 90.39  ? 87  HIS B C   1 
ATOM 4226 O O   . HIS B 1 89  ? 64.186 -81.841  13.939  1.00 83.02  ? 87  HIS B O   1 
ATOM 4227 C CB  . HIS B 1 89  ? 63.597 -85.007  14.768  1.00 82.38  ? 87  HIS B CB  1 
ATOM 4228 C CG  . HIS B 1 89  ? 64.061 -86.373  14.382  1.00 86.21  ? 87  HIS B CG  1 
ATOM 4229 N ND1 . HIS B 1 89  ? 65.376 -86.680  14.108  1.00 89.45  ? 87  HIS B ND1 1 
ATOM 4230 C CD2 . HIS B 1 89  ? 63.364 -87.504  14.168  1.00 89.26  ? 87  HIS B CD2 1 
ATOM 4231 C CE1 . HIS B 1 89  ? 65.461 -87.956  13.750  1.00 90.88  ? 87  HIS B CE1 1 
ATOM 4232 N NE2 . HIS B 1 89  ? 64.253 -88.480  13.796  1.00 92.08  ? 87  HIS B NE2 1 
ATOM 4233 N N   . ASP B 1 90  ? 63.819 -82.118  16.154  1.00 104.41 ? 88  ASP B N   1 
ATOM 4234 C CA  . ASP B 1 90  ? 63.185 -80.824  16.376  1.00 92.39  ? 88  ASP B CA  1 
ATOM 4235 C C   . ASP B 1 90  ? 64.090 -79.676  15.917  1.00 81.02  ? 88  ASP B C   1 
ATOM 4236 O O   . ASP B 1 90  ? 63.598 -78.558  15.806  1.00 68.78  ? 88  ASP B O   1 
ATOM 4237 C CB  . ASP B 1 90  ? 62.679 -80.675  17.810  1.00 100.40 ? 88  ASP B CB  1 
ATOM 4238 C CG  . ASP B 1 90  ? 63.671 -80.927  18.944  1.00 113.49 ? 88  ASP B CG  1 
ATOM 4239 O OD1 . ASP B 1 90  ? 64.597 -80.101  19.120  1.00 106.43 ? 88  ASP B OD1 1 
ATOM 4240 O OD2 . ASP B 1 90  ? 63.518 -81.956  19.648  1.00 112.99 ? 88  ASP B OD2 1 
ATOM 4241 N N   . GLN B 1 91  ? 65.379 -79.951  15.647  1.00 77.87  ? 89  GLN B N   1 
ATOM 4242 C CA  . GLN B 1 91  ? 66.358 -78.942  15.267  1.00 83.95  ? 89  GLN B CA  1 
ATOM 4243 C C   . GLN B 1 91  ? 66.440 -78.746  13.756  1.00 76.41  ? 89  GLN B C   1 
ATOM 4244 O O   . GLN B 1 91  ? 67.092 -77.806  13.299  1.00 64.77  ? 89  GLN B O   1 
ATOM 4245 C CB  . GLN B 1 91  ? 67.761 -79.361  15.713  1.00 101.13 ? 89  GLN B CB  1 
ATOM 4246 C CG  . GLN B 1 91  ? 67.977 -79.295  17.223  1.00 100.58 ? 89  GLN B CG  1 
ATOM 4247 C CD  . GLN B 1 91  ? 67.733 -77.905  17.768  1.00 88.95  ? 89  GLN B CD  1 
ATOM 4248 O OE1 . GLN B 1 91  ? 68.512 -76.975  17.539  1.00 77.80  ? 89  GLN B OE1 1 
ATOM 4249 N NE2 . GLN B 1 91  ? 66.617 -77.743  18.462  1.00 88.92  ? 89  GLN B NE2 1 
ATOM 4250 N N   . PHE B 1 92  ? 65.865 -79.692  13.000  1.00 75.32  ? 90  PHE B N   1 
ATOM 4251 C CA  . PHE B 1 92  ? 65.710 -79.554  11.560  1.00 74.72  ? 90  PHE B CA  1 
ATOM 4252 C C   . PHE B 1 92  ? 64.490 -78.683  11.257  1.00 75.51  ? 90  PHE B C   1 
ATOM 4253 O O   . PHE B 1 92  ? 63.356 -79.137  11.376  1.00 76.95  ? 90  PHE B O   1 
ATOM 4254 C CB  . PHE B 1 92  ? 65.625 -80.961  10.966  1.00 72.79  ? 90  PHE B CB  1 
ATOM 4255 C CG  . PHE B 1 92  ? 66.970 -81.665  10.964  1.00 81.70  ? 90  PHE B CG  1 
ATOM 4256 C CD1 . PHE B 1 92  ? 67.452 -82.303  12.096  1.00 96.32  ? 90  PHE B CD1 1 
ATOM 4257 C CD2 . PHE B 1 92  ? 67.773 -81.640  9.838   1.00 86.32  ? 90  PHE B CD2 1 
ATOM 4258 C CE1 . PHE B 1 92  ? 68.692 -82.921  12.081  1.00 92.63  ? 90  PHE B CE1 1 
ATOM 4259 C CE2 . PHE B 1 92  ? 69.004 -82.265  9.828   1.00 82.12  ? 90  PHE B CE2 1 
ATOM 4260 C CZ  . PHE B 1 92  ? 69.461 -82.899  10.945  1.00 88.28  ? 90  PHE B CZ  1 
ATOM 4261 N N   . ILE B 1 93  ? 64.732 -77.437  10.833  1.00 75.08  ? 91  ILE B N   1 
ATOM 4262 C CA  . ILE B 1 93  ? 63.697 -76.412  10.842  1.00 77.19  ? 91  ILE B CA  1 
ATOM 4263 C C   . ILE B 1 93  ? 63.590 -75.691  9.496   1.00 79.53  ? 91  ILE B C   1 
ATOM 4264 O O   . ILE B 1 93  ? 62.855 -74.714  9.392   1.00 73.40  ? 91  ILE B O   1 
ATOM 4265 C CB  . ILE B 1 93  ? 63.962 -75.395  11.966  1.00 79.71  ? 91  ILE B CB  1 
ATOM 4266 C CG1 . ILE B 1 93  ? 65.302 -74.665  11.760  1.00 79.91  ? 91  ILE B CG1 1 
ATOM 4267 C CG2 . ILE B 1 93  ? 63.880 -76.064  13.338  1.00 83.86  ? 91  ILE B CG2 1 
ATOM 4268 C CD1 . ILE B 1 93  ? 65.469 -73.416  12.597  1.00 75.62  ? 91  ILE B CD1 1 
ATOM 4269 N N   . VAL B 1 94  ? 64.306 -76.149  8.467   1.00 81.13  ? 92  VAL B N   1 
ATOM 4270 C CA  . VAL B 1 94  ? 64.170 -75.533  7.160   1.00 75.08  ? 92  VAL B CA  1 
ATOM 4271 C C   . VAL B 1 94  ? 62.926 -76.111  6.491   1.00 75.34  ? 92  VAL B C   1 
ATOM 4272 O O   . VAL B 1 94  ? 62.499 -77.229  6.816   1.00 70.64  ? 92  VAL B O   1 
ATOM 4273 C CB  . VAL B 1 94  ? 65.419 -75.694  6.277   1.00 79.47  ? 92  VAL B CB  1 
ATOM 4274 C CG1 . VAL B 1 94  ? 66.580 -74.873  6.825   1.00 80.18  ? 92  VAL B CG1 1 
ATOM 4275 C CG2 . VAL B 1 94  ? 65.810 -77.157  6.078   1.00 76.04  ? 92  VAL B CG2 1 
ATOM 4276 N N   . ASP B 1 95  ? 62.393 -75.314  5.550   1.00 74.39  ? 93  ASP B N   1 
ATOM 4277 C CA  . ASP B 1 95  ? 61.098 -75.527  4.922   1.00 72.57  ? 93  ASP B CA  1 
ATOM 4278 C C   . ASP B 1 95  ? 61.257 -76.473  3.733   1.00 71.25  ? 93  ASP B C   1 
ATOM 4279 O O   . ASP B 1 95  ? 62.140 -76.256  2.906   1.00 74.92  ? 93  ASP B O   1 
ATOM 4280 C CB  . ASP B 1 95  ? 60.535 -74.198  4.444   1.00 69.50  ? 93  ASP B CB  1 
ATOM 4281 C CG  . ASP B 1 95  ? 59.026 -74.151  4.261   1.00 64.53  ? 93  ASP B CG  1 
ATOM 4282 O OD1 . ASP B 1 95  ? 58.483 -75.052  3.574   1.00 53.05  ? 93  ASP B OD1 1 
ATOM 4283 O OD2 . ASP B 1 95  ? 58.413 -73.196  4.795   1.00 62.85  ? 93  ASP B OD2 1 
ATOM 4284 N N   . PRO B 1 96  ? 60.412 -77.526  3.579   1.00 67.27  ? 94  PRO B N   1 
ATOM 4285 C CA  . PRO B 1 96  ? 60.608 -78.522  2.514   1.00 60.19  ? 94  PRO B CA  1 
ATOM 4286 C C   . PRO B 1 96  ? 60.620 -77.868  1.140   1.00 62.24  ? 94  PRO B C   1 
ATOM 4287 O O   . PRO B 1 96  ? 61.361 -78.304  0.272   1.00 70.21  ? 94  PRO B O   1 
ATOM 4288 C CB  . PRO B 1 96  ? 59.451 -79.513  2.636   1.00 60.64  ? 94  PRO B CB  1 
ATOM 4289 C CG  . PRO B 1 96  ? 58.870 -79.237  4.016   1.00 66.23  ? 94  PRO B CG  1 
ATOM 4290 C CD  . PRO B 1 96  ? 59.223 -77.802  4.407   1.00 66.87  ? 94  PRO B CD  1 
ATOM 4291 N N   . ILE B 1 97  ? 59.775 -76.839  0.978   1.00 59.53  ? 95  ILE B N   1 
ATOM 4292 C CA  . ILE B 1 97  ? 59.770 -75.985  -0.196  1.00 56.89  ? 95  ILE B CA  1 
ATOM 4293 C C   . ILE B 1 97  ? 60.728 -74.819  0.025   1.00 55.24  ? 95  ILE B C   1 
ATOM 4294 O O   . ILE B 1 97  ? 60.400 -73.885  0.761   1.00 56.28  ? 95  ILE B O   1 
ATOM 4295 C CB  . ILE B 1 97  ? 58.341 -75.503  -0.498  1.00 59.30  ? 95  ILE B CB  1 
ATOM 4296 C CG1 . ILE B 1 97  ? 57.446 -76.669  -0.878  1.00 61.32  ? 95  ILE B CG1 1 
ATOM 4297 C CG2 . ILE B 1 97  ? 58.315 -74.411  -1.573  1.00 57.51  ? 95  ILE B CG2 1 
ATOM 4298 C CD1 . ILE B 1 97  ? 56.062 -76.251  -1.337  1.00 62.95  ? 95  ILE B CD1 1 
ATOM 4299 N N   . GLN B 1 98  ? 61.885 -74.877  -0.651  1.00 56.46  ? 96  GLN B N   1 
ATOM 4300 C CA  . GLN B 1 98  ? 62.966 -73.930  -0.429  1.00 60.16  ? 96  GLN B CA  1 
ATOM 4301 C C   . GLN B 1 98  ? 63.825 -73.764  -1.677  1.00 55.46  ? 96  GLN B C   1 
ATOM 4302 O O   . GLN B 1 98  ? 63.999 -74.702  -2.437  1.00 50.55  ? 96  GLN B O   1 
ATOM 4303 C CB  . GLN B 1 98  ? 63.868 -74.465  0.677   1.00 62.75  ? 96  GLN B CB  1 
ATOM 4304 C CG  . GLN B 1 98  ? 64.395 -75.871  0.414   1.00 62.00  ? 96  GLN B CG  1 
ATOM 4305 C CD  . GLN B 1 98  ? 65.401 -76.295  1.456   1.00 65.22  ? 96  GLN B CD  1 
ATOM 4306 O OE1 . GLN B 1 98  ? 65.042 -76.590  2.598   1.00 66.78  ? 96  GLN B OE1 1 
ATOM 4307 N NE2 . GLN B 1 98  ? 66.673 -76.291  1.083   1.00 66.67  ? 96  GLN B NE2 1 
ATOM 4308 N N   . GLY B 1 99  ? 64.376 -72.564  -1.854  1.00 55.83  ? 97  GLY B N   1 
ATOM 4309 C CA  . GLY B 1 99  ? 65.400 -72.321  -2.851  1.00 65.98  ? 97  GLY B CA  1 
ATOM 4310 C C   . GLY B 1 99  ? 66.728 -73.000  -2.513  1.00 72.03  ? 97  GLY B C   1 
ATOM 4311 O O   . GLY B 1 99  ? 66.904 -73.593  -1.443  1.00 77.41  ? 97  GLY B O   1 
ATOM 4312 N N   . GLY B 1 100 ? 67.651 -72.933  -3.482  1.00 68.88  ? 98  GLY B N   1 
ATOM 4313 C CA  . GLY B 1 100 ? 69.014 -73.385  -3.288  1.00 70.35  ? 98  GLY B CA  1 
ATOM 4314 C C   . GLY B 1 100 ? 69.171 -74.892  -3.486  1.00 72.76  ? 98  GLY B C   1 
ATOM 4315 O O   . GLY B 1 100 ? 70.193 -75.442  -3.085  1.00 79.24  ? 98  GLY B O   1 
ATOM 4316 N N   . ALA B 1 101 ? 68.175 -75.555  -4.098  1.00 65.57  ? 99  ALA B N   1 
ATOM 4317 C CA  . ALA B 1 101 ? 68.350 -76.915  -4.583  1.00 61.99  ? 99  ALA B CA  1 
ATOM 4318 C C   . ALA B 1 101 ? 68.521 -77.922  -3.449  1.00 62.79  ? 99  ALA B C   1 
ATOM 4319 O O   . ALA B 1 101 ? 68.860 -79.061  -3.712  1.00 57.70  ? 99  ALA B O   1 
ATOM 4320 C CB  . ALA B 1 101 ? 69.549 -76.976  -5.503  1.00 63.08  ? 99  ALA B CB  1 
ATOM 4321 N N   . GLY B 1 102 ? 68.258 -77.526  -2.202  1.00 74.10  ? 100 GLY B N   1 
ATOM 4322 C CA  . GLY B 1 102 ? 68.401 -78.435  -1.076  1.00 78.49  ? 100 GLY B CA  1 
ATOM 4323 C C   . GLY B 1 102 ? 69.744 -78.266  -0.364  1.00 82.12  ? 100 GLY B C   1 
ATOM 4324 O O   . GLY B 1 102 ? 70.201 -79.181  0.322   1.00 82.30  ? 100 GLY B O   1 
ATOM 4325 N N   . THR B 1 103 ? 70.362 -77.088  -0.521  1.00 84.48  ? 101 THR B N   1 
ATOM 4326 C CA  . THR B 1 103 ? 71.579 -76.752  0.204   1.00 77.77  ? 101 THR B CA  1 
ATOM 4327 C C   . THR B 1 103 ? 71.212 -76.433  1.648   1.00 79.78  ? 101 THR B C   1 
ATOM 4328 O O   . THR B 1 103 ? 71.876 -76.878  2.578   1.00 89.13  ? 101 THR B O   1 
ATOM 4329 C CB  . THR B 1 103 ? 72.305 -75.589  -0.474  1.00 77.74  ? 101 THR B CB  1 
ATOM 4330 O OG1 . THR B 1 103 ? 73.199 -76.169  -1.413  1.00 78.22  ? 101 THR B OG1 1 
ATOM 4331 C CG2 . THR B 1 103 ? 73.190 -74.791  0.460   1.00 78.83  ? 101 THR B CG2 1 
ATOM 4332 N N   . SER B 1 104 ? 70.131 -75.679  1.833   1.00 78.41  ? 102 SER B N   1 
ATOM 4333 C CA  . SER B 1 104 ? 69.714 -75.316  3.172   1.00 72.27  ? 102 SER B CA  1 
ATOM 4334 C C   . SER B 1 104 ? 69.278 -76.546  3.977   1.00 84.95  ? 102 SER B C   1 
ATOM 4335 O O   . SER B 1 104 ? 69.248 -76.465  5.195   1.00 95.08  ? 102 SER B O   1 
ATOM 4336 C CB  . SER B 1 104 ? 68.659 -74.261  3.120   1.00 66.06  ? 102 SER B CB  1 
ATOM 4337 O OG  . SER B 1 104 ? 69.144 -73.154  2.373   1.00 64.72  ? 102 SER B OG  1 
ATOM 4338 N N   . ILE B 1 105 ? 68.969 -77.692  3.339   1.00 92.75  ? 103 ILE B N   1 
ATOM 4339 C CA  . ILE B 1 105 ? 68.717 -78.922  4.089   1.00 86.43  ? 103 ILE B CA  1 
ATOM 4340 C C   . ILE B 1 105 ? 70.057 -79.511  4.523   1.00 92.66  ? 103 ILE B C   1 
ATOM 4341 O O   . ILE B 1 105 ? 70.281 -79.784  5.701   1.00 93.50  ? 103 ILE B O   1 
ATOM 4342 C CB  . ILE B 1 105 ? 67.888 -79.957  3.303   1.00 79.26  ? 103 ILE B CB  1 
ATOM 4343 C CG1 . ILE B 1 105 ? 66.500 -79.432  2.964   1.00 81.30  ? 103 ILE B CG1 1 
ATOM 4344 C CG2 . ILE B 1 105 ? 67.802 -81.278  4.070   1.00 71.88  ? 103 ILE B CG2 1 
ATOM 4345 C CD1 . ILE B 1 105 ? 65.689 -80.330  2.053   1.00 78.74  ? 103 ILE B CD1 1 
ATOM 4346 N N   . ASN B 1 106 ? 70.941 -79.713  3.546   1.00 92.07  ? 104 ASN B N   1 
ATOM 4347 C CA  . ASN B 1 106 ? 72.284 -80.197  3.810   1.00 94.16  ? 104 ASN B CA  1 
ATOM 4348 C C   . ASN B 1 106 ? 72.904 -79.401  4.958   1.00 84.84  ? 104 ASN B C   1 
ATOM 4349 O O   . ASN B 1 106 ? 73.447 -79.997  5.885   1.00 88.86  ? 104 ASN B O   1 
ATOM 4350 C CB  . ASN B 1 106 ? 73.125 -80.140  2.541   1.00 109.60 ? 104 ASN B CB  1 
ATOM 4351 C CG  . ASN B 1 106 ? 74.413 -80.923  2.643   1.00 105.43 ? 104 ASN B CG  1 
ATOM 4352 O OD1 . ASN B 1 106 ? 74.391 -82.131  2.919   1.00 97.19  ? 104 ASN B OD1 1 
ATOM 4353 N ND2 . ASN B 1 106 ? 75.534 -80.255  2.399   1.00 99.63  ? 104 ASN B ND2 1 
ATOM 4354 N N   . MET B 1 107 ? 72.805 -78.064  4.906   1.00 73.80  ? 105 MET B N   1 
ATOM 4355 C CA  . MET B 1 107 ? 73.441 -77.224  5.907   1.00 77.98  ? 105 MET B CA  1 
ATOM 4356 C C   . MET B 1 107 ? 72.795 -77.399  7.281   1.00 75.91  ? 105 MET B C   1 
ATOM 4357 O O   . MET B 1 107 ? 73.491 -77.337  8.292   1.00 87.30  ? 105 MET B O   1 
ATOM 4358 C CB  . MET B 1 107 ? 73.421 -75.744  5.515   1.00 87.79  ? 105 MET B CB  1 
ATOM 4359 C CG  . MET B 1 107 ? 74.366 -75.393  4.383   1.00 100.45 ? 105 MET B CG  1 
ATOM 4360 S SD  . MET B 1 107 ? 75.976 -76.201  4.484   1.00 135.63 ? 105 MET B SD  1 
ATOM 4361 C CE  . MET B 1 107 ? 76.558 -75.499  6.037   1.00 137.53 ? 105 MET B CE  1 
ATOM 4362 N N   . ASN B 1 108 ? 71.490 -77.682  7.319   1.00 75.85  ? 106 ASN B N   1 
ATOM 4363 C CA  . ASN B 1 108 ? 70.794 -77.828  8.589   1.00 82.19  ? 106 ASN B CA  1 
ATOM 4364 C C   . ASN B 1 108 ? 71.342 -79.045  9.322   1.00 81.96  ? 106 ASN B C   1 
ATOM 4365 O O   . ASN B 1 108 ? 71.556 -78.976  10.533  1.00 94.36  ? 106 ASN B O   1 
ATOM 4366 C CB  . ASN B 1 108 ? 69.280 -77.920  8.424   1.00 82.80  ? 106 ASN B CB  1 
ATOM 4367 C CG  . ASN B 1 108 ? 68.503 -77.584  9.675   1.00 85.43  ? 106 ASN B CG  1 
ATOM 4368 O OD1 . ASN B 1 108 ? 67.272 -77.496  9.615   1.00 84.07  ? 106 ASN B OD1 1 
ATOM 4369 N ND2 . ASN B 1 108 ? 69.178 -77.351  10.792  1.00 98.42  ? 106 ASN B ND2 1 
ATOM 4370 N N   . ALA B 1 109 ? 71.627 -80.110  8.559   1.00 77.81  ? 107 ALA B N   1 
ATOM 4371 C CA  . ALA B 1 109 ? 72.268 -81.293  9.114   1.00 74.33  ? 107 ALA B CA  1 
ATOM 4372 C C   . ALA B 1 109 ? 73.690 -80.951  9.552   1.00 81.52  ? 107 ALA B C   1 
ATOM 4373 O O   . ALA B 1 109 ? 74.096 -81.244  10.681  1.00 94.69  ? 107 ALA B O   1 
ATOM 4374 C CB  . ALA B 1 109 ? 72.274 -82.409  8.103   1.00 70.42  ? 107 ALA B CB  1 
ATOM 4375 N N   . ASN B 1 110 ? 74.419 -80.255  8.676   1.00 78.26  ? 108 ASN B N   1 
ATOM 4376 C CA  . ASN B 1 110 ? 75.814 -79.948  8.949   1.00 78.47  ? 108 ASN B CA  1 
ATOM 4377 C C   . ASN B 1 110 ? 75.933 -79.200  10.278  1.00 88.78  ? 108 ASN B C   1 
ATOM 4378 O O   . ASN B 1 110 ? 76.704 -79.592  11.154  1.00 96.29  ? 108 ASN B O   1 
ATOM 4379 C CB  . ASN B 1 110 ? 76.443 -79.199  7.782   1.00 73.83  ? 108 ASN B CB  1 
ATOM 4380 C CG  . ASN B 1 110 ? 76.678 -80.098  6.584   1.00 78.14  ? 108 ASN B CG  1 
ATOM 4381 O OD1 . ASN B 1 110 ? 76.865 -81.313  6.731   1.00 82.20  ? 108 ASN B OD1 1 
ATOM 4382 N ND2 . ASN B 1 110 ? 76.718 -79.518  5.393   1.00 79.90  ? 108 ASN B ND2 1 
ATOM 4383 N N   . GLU B 1 111 ? 75.112 -78.153  10.421  1.00 100.87 ? 109 GLU B N   1 
ATOM 4384 C CA  . GLU B 1 111 ? 75.151 -77.258  11.567  1.00 98.59  ? 109 GLU B CA  1 
ATOM 4385 C C   . GLU B 1 111 ? 74.655 -77.937  12.847  1.00 94.97  ? 109 GLU B C   1 
ATOM 4386 O O   . GLU B 1 111 ? 75.114 -77.583  13.935  1.00 101.30 ? 109 GLU B O   1 
ATOM 4387 C CB  . GLU B 1 111 ? 74.382 -75.976  11.238  1.00 91.12  ? 109 GLU B CB  1 
ATOM 4388 C CG  . GLU B 1 111 ? 75.119 -75.095  10.230  1.00 86.95  ? 109 GLU B CG  1 
ATOM 4389 C CD  . GLU B 1 111 ? 74.372 -73.832  9.848   1.00 99.00  ? 109 GLU B CD  1 
ATOM 4390 O OE1 . GLU B 1 111 ? 73.191 -73.717  10.242  1.00 115.40 ? 109 GLU B OE1 1 
ATOM 4391 O OE2 . GLU B 1 111 ? 74.959 -72.965  9.167   1.00 108.57 ? 109 GLU B OE2 1 
ATOM 4392 N N   . VAL B 1 112 ? 73.729 -78.898  12.743  1.00 90.12  ? 110 VAL B N   1 
ATOM 4393 C CA  . VAL B 1 112 ? 73.245 -79.588  13.930  1.00 90.15  ? 110 VAL B CA  1 
ATOM 4394 C C   . VAL B 1 112 ? 74.236 -80.680  14.329  1.00 96.34  ? 110 VAL B C   1 
ATOM 4395 O O   . VAL B 1 112 ? 74.601 -80.777  15.492  1.00 112.02 ? 110 VAL B O   1 
ATOM 4396 C CB  . VAL B 1 112 ? 71.814 -80.132  13.754  1.00 90.17  ? 110 VAL B CB  1 
ATOM 4397 C CG1 . VAL B 1 112 ? 71.495 -81.294  14.695  1.00 82.94  ? 110 VAL B CG1 1 
ATOM 4398 C CG2 . VAL B 1 112 ? 70.783 -79.012  13.888  1.00 89.72  ? 110 VAL B CG2 1 
ATOM 4399 N N   . ILE B 1 113 ? 74.692 -81.499  13.384  1.00 105.42 ? 111 ILE B N   1 
ATOM 4400 C CA  . ILE B 1 113 ? 75.618 -82.570  13.723  1.00 113.04 ? 111 ILE B CA  1 
ATOM 4401 C C   . ILE B 1 113 ? 76.896 -81.985  14.336  1.00 112.58 ? 111 ILE B C   1 
ATOM 4402 O O   . ILE B 1 113 ? 77.454 -82.586  15.255  1.00 119.90 ? 111 ILE B O   1 
ATOM 4403 C CB  . ILE B 1 113 ? 75.887 -83.473  12.502  1.00 112.43 ? 111 ILE B CB  1 
ATOM 4404 C CG1 . ILE B 1 113 ? 74.646 -84.286  12.154  1.00 101.51 ? 111 ILE B CG1 1 
ATOM 4405 C CG2 . ILE B 1 113 ? 77.092 -84.389  12.732  1.00 116.17 ? 111 ILE B CG2 1 
ATOM 4406 C CD1 . ILE B 1 113 ? 74.729 -84.991  10.816  1.00 102.63 ? 111 ILE B CD1 1 
ATOM 4407 N N   . ALA B 1 114 ? 77.345 -80.815  13.849  1.00 99.40  ? 112 ALA B N   1 
ATOM 4408 C CA  . ALA B 1 114 ? 78.545 -80.175  14.374  1.00 97.43  ? 112 ALA B CA  1 
ATOM 4409 C C   . ALA B 1 114 ? 78.352 -79.751  15.835  1.00 97.07  ? 112 ALA B C   1 
ATOM 4410 O O   . ALA B 1 114 ? 79.099 -80.172  16.716  1.00 102.07 ? 112 ALA B O   1 
ATOM 4411 C CB  . ALA B 1 114 ? 78.929 -78.993  13.514  1.00 95.85  ? 112 ALA B CB  1 
ATOM 4412 N N   . ASN B 1 115 ? 77.333 -78.923  16.087  1.00 99.75  ? 113 ASN B N   1 
ATOM 4413 C CA  . ASN B 1 115 ? 77.088 -78.372  17.411  1.00 108.77 ? 113 ASN B CA  1 
ATOM 4414 C C   . ASN B 1 115 ? 76.790 -79.464  18.437  1.00 101.23 ? 113 ASN B C   1 
ATOM 4415 O O   . ASN B 1 115 ? 76.884 -79.209  19.631  1.00 120.11 ? 113 ASN B O   1 
ATOM 4416 C CB  . ASN B 1 115 ? 75.939 -77.362  17.430  1.00 118.38 ? 113 ASN B CB  1 
ATOM 4417 C CG  . ASN B 1 115 ? 76.377 -75.989  16.983  1.00 124.46 ? 113 ASN B CG  1 
ATOM 4418 O OD1 . ASN B 1 115 ? 77.492 -75.554  17.304  1.00 125.81 ? 113 ASN B OD1 1 
ATOM 4419 N ND2 . ASN B 1 115 ? 75.524 -75.301  16.239  1.00 130.80 ? 113 ASN B ND2 1 
ATOM 4420 N N   . ARG B 1 116 ? 76.393 -80.655  17.986  1.00 90.85  ? 114 ARG B N   1 
ATOM 4421 C CA  . ARG B 1 116 ? 76.077 -81.732  18.907  1.00 99.47  ? 114 ARG B CA  1 
ATOM 4422 C C   . ARG B 1 116 ? 77.270 -82.673  19.026  1.00 122.18 ? 114 ARG B C   1 
ATOM 4423 O O   . ARG B 1 116 ? 77.372 -83.409  20.006  1.00 139.50 ? 114 ARG B O   1 
ATOM 4424 C CB  . ARG B 1 116 ? 74.807 -82.472  18.472  1.00 99.21  ? 114 ARG B CB  1 
ATOM 4425 C CG  . ARG B 1 116 ? 74.463 -83.733  19.249  1.00 96.48  ? 114 ARG B CG  1 
ATOM 4426 C CD  . ARG B 1 116 ? 74.369 -83.450  20.726  1.00 107.38 ? 114 ARG B CD  1 
ATOM 4427 N NE  . ARG B 1 116 ? 74.335 -84.711  21.469  1.00 115.54 ? 114 ARG B NE  1 
ATOM 4428 C CZ  . ARG B 1 116 ? 74.507 -84.811  22.777  1.00 100.87 ? 114 ARG B CZ  1 
ATOM 4429 N NH1 . ARG B 1 116 ? 74.838 -83.744  23.488  1.00 98.32  ? 114 ARG B NH1 1 
ATOM 4430 N NH2 . ARG B 1 116 ? 74.352 -85.987  23.357  1.00 88.13  ? 114 ARG B NH2 1 
ATOM 4431 N N   . ALA B 1 117 ? 78.154 -82.671  18.018  1.00 137.70 ? 115 ALA B N   1 
ATOM 4432 C CA  . ALA B 1 117 ? 79.446 -83.325  18.155  1.00 141.62 ? 115 ALA B CA  1 
ATOM 4433 C C   . ALA B 1 117 ? 80.324 -82.528  19.121  1.00 131.69 ? 115 ALA B C   1 
ATOM 4434 O O   . ALA B 1 117 ? 81.098 -83.124  19.875  1.00 113.77 ? 115 ALA B O   1 
ATOM 4435 C CB  . ALA B 1 117 ? 80.103 -83.501  16.804  1.00 144.44 ? 115 ALA B CB  1 
ATOM 4436 N N   . LEU B 1 118 ? 80.170 -81.189  19.103  1.00 121.95 ? 116 LEU B N   1 
ATOM 4437 C CA  . LEU B 1 118 ? 80.818 -80.302  20.062  1.00 107.57 ? 116 LEU B CA  1 
ATOM 4438 C C   . LEU B 1 118 ? 80.432 -80.719  21.479  1.00 105.78 ? 116 LEU B C   1 
ATOM 4439 O O   . LEU B 1 118 ? 81.270 -81.208  22.233  1.00 120.65 ? 116 LEU B O   1 
ATOM 4440 C CB  . LEU B 1 118 ? 80.473 -78.834  19.802  1.00 98.66  ? 116 LEU B CB  1 
ATOM 4441 C CG  . LEU B 1 118 ? 81.110 -78.201  18.559  1.00 104.85 ? 116 LEU B CG  1 
ATOM 4442 C CD1 . LEU B 1 118 ? 80.594 -76.785  18.372  1.00 112.81 ? 116 LEU B CD1 1 
ATOM 4443 C CD2 . LEU B 1 118 ? 82.633 -78.192  18.622  1.00 100.79 ? 116 LEU B CD2 1 
ATOM 4444 N N   . GLU B 1 119 ? 79.148 -80.564  21.819  1.00 107.81 ? 117 GLU B N   1 
ATOM 4445 C CA  . GLU B 1 119 ? 78.636 -80.999  23.109  1.00 112.88 ? 117 GLU B CA  1 
ATOM 4446 C C   . GLU B 1 119 ? 79.258 -82.334  23.538  1.00 118.46 ? 117 GLU B C   1 
ATOM 4447 O O   . GLU B 1 119 ? 79.597 -82.509  24.705  1.00 111.87 ? 117 GLU B O   1 
ATOM 4448 C CB  . GLU B 1 119 ? 77.110 -81.069  23.087  1.00 108.93 ? 117 GLU B CB  1 
ATOM 4449 C CG  . GLU B 1 119 ? 76.422 -79.741  23.401  1.00 107.96 ? 117 GLU B CG  1 
ATOM 4450 C CD  . GLU B 1 119 ? 74.995 -79.908  23.893  1.00 114.75 ? 117 GLU B CD  1 
ATOM 4451 O OE1 . GLU B 1 119 ? 74.425 -81.023  23.760  1.00 124.47 ? 117 GLU B OE1 1 
ATOM 4452 O OE2 . GLU B 1 119 ? 74.466 -78.919  24.444  1.00 104.44 ? 117 GLU B OE2 1 
ATOM 4453 N N   . ILE B 1 120 ? 79.411 -83.286  22.605  1.00 117.81 ? 118 ILE B N   1 
ATOM 4454 C CA  . ILE B 1 120 ? 79.851 -84.633  22.957  1.00 121.44 ? 118 ILE B CA  1 
ATOM 4455 C C   . ILE B 1 120 ? 81.370 -84.676  23.159  1.00 122.82 ? 118 ILE B C   1 
ATOM 4456 O O   . ILE B 1 120 ? 81.875 -85.630  23.749  1.00 125.15 ? 118 ILE B O   1 
ATOM 4457 C CB  . ILE B 1 120 ? 79.345 -85.680  21.945  1.00 123.59 ? 118 ILE B CB  1 
ATOM 4458 C CG1 . ILE B 1 120 ? 77.817 -85.858  22.046  1.00 120.86 ? 118 ILE B CG1 1 
ATOM 4459 C CG2 . ILE B 1 120 ? 80.051 -87.022  22.155  1.00 121.60 ? 118 ILE B CG2 1 
ATOM 4460 C CD1 . ILE B 1 120 ? 77.192 -86.715  20.960  1.00 116.99 ? 118 ILE B CD1 1 
ATOM 4461 N N   . MET B 1 121 ? 82.090 -83.643  22.694  1.00 119.95 ? 119 MET B N   1 
ATOM 4462 C CA  . MET B 1 121 ? 83.484 -83.397  23.056  1.00 116.54 ? 119 MET B CA  1 
ATOM 4463 C C   . MET B 1 121 ? 83.595 -82.530  24.315  1.00 125.47 ? 119 MET B C   1 
ATOM 4464 O O   . MET B 1 121 ? 84.672 -82.026  24.620  1.00 139.30 ? 119 MET B O   1 
ATOM 4465 C CB  . MET B 1 121 ? 84.217 -82.609  21.960  1.00 109.76 ? 119 MET B CB  1 
ATOM 4466 C CG  . MET B 1 121 ? 84.393 -83.319  20.643  1.00 120.86 ? 119 MET B CG  1 
ATOM 4467 S SD  . MET B 1 121 ? 85.142 -82.243  19.399  1.00 144.30 ? 119 MET B SD  1 
ATOM 4468 C CE  . MET B 1 121 ? 86.657 -81.625  20.147  1.00 146.27 ? 119 MET B CE  1 
ATOM 4469 N N   . GLY B 1 122 ? 82.480 -82.307  25.023  1.00 118.55 ? 120 GLY B N   1 
ATOM 4470 C CA  . GLY B 1 122 ? 82.471 -81.471  26.211  1.00 106.01 ? 120 GLY B CA  1 
ATOM 4471 C C   . GLY B 1 122 ? 82.454 -79.973  25.892  1.00 107.51 ? 120 GLY B C   1 
ATOM 4472 O O   . GLY B 1 122 ? 82.174 -79.179  26.788  1.00 121.70 ? 120 GLY B O   1 
ATOM 4473 N N   . LYS B 1 123 ? 82.716 -79.585  24.630  1.00 110.14 ? 121 LYS B N   1 
ATOM 4474 C CA  . LYS B 1 123 ? 82.832 -78.181  24.246  1.00 111.26 ? 121 LYS B CA  1 
ATOM 4475 C C   . LYS B 1 123 ? 81.435 -77.560  24.154  1.00 119.33 ? 121 LYS B C   1 
ATOM 4476 O O   . LYS B 1 123 ? 80.441 -78.168  24.542  1.00 111.40 ? 121 LYS B O   1 
ATOM 4477 C CB  . LYS B 1 123 ? 83.574 -77.983  22.915  1.00 108.12 ? 121 LYS B CB  1 
ATOM 4478 C CG  . LYS B 1 123 ? 84.715 -78.943  22.602  1.00 104.99 ? 121 LYS B CG  1 
ATOM 4479 C CD  . LYS B 1 123 ? 85.735 -79.112  23.718  1.00 112.96 ? 121 LYS B CD  1 
ATOM 4480 C CE  . LYS B 1 123 ? 86.646 -77.948  23.862  1.00 127.77 ? 121 LYS B CE  1 
ATOM 4481 N NZ  . LYS B 1 123 ? 87.631 -77.969  22.776  1.00 136.77 ? 121 LYS B NZ  1 
ATOM 4482 N N   . LYS B 1 124 ? 81.356 -76.321  23.662  1.00 127.33 ? 122 LYS B N   1 
ATOM 4483 C CA  . LYS B 1 124 ? 80.086 -75.623  23.587  1.00 126.81 ? 122 LYS B CA  1 
ATOM 4484 C C   . LYS B 1 124 ? 79.745 -75.344  22.133  1.00 131.21 ? 122 LYS B C   1 
ATOM 4485 O O   . LYS B 1 124 ? 80.619 -75.312  21.271  1.00 142.98 ? 122 LYS B O   1 
ATOM 4486 C CB  . LYS B 1 124 ? 80.145 -74.381  24.487  1.00 129.66 ? 122 LYS B CB  1 
ATOM 4487 C CG  . LYS B 1 124 ? 79.758 -74.745  25.924  1.00 129.41 ? 122 LYS B CG  1 
ATOM 4488 C CD  . LYS B 1 124 ? 80.511 -74.131  27.098  1.00 113.46 ? 122 LYS B CD  1 
ATOM 4489 C CE  . LYS B 1 124 ? 80.392 -75.063  28.260  1.00 100.45 ? 122 LYS B CE  1 
ATOM 4490 N NZ  . LYS B 1 124 ? 80.950 -74.427  29.445  1.00 110.37 ? 122 LYS B NZ  1 
ATOM 4491 N N   . LYS B 1 125 ? 78.451 -75.136  21.895  1.00 124.88 ? 123 LYS B N   1 
ATOM 4492 C CA  . LYS B 1 125 ? 77.948 -74.864  20.561  1.00 121.58 ? 123 LYS B CA  1 
ATOM 4493 C C   . LYS B 1 125 ? 78.550 -73.563  20.048  1.00 113.77 ? 123 LYS B C   1 
ATOM 4494 O O   . LYS B 1 125 ? 78.845 -72.664  20.827  1.00 116.47 ? 123 LYS B O   1 
ATOM 4495 C CB  . LYS B 1 125 ? 76.423 -74.758  20.615  1.00 117.37 ? 123 LYS B CB  1 
ATOM 4496 C CG  . LYS B 1 125 ? 75.713 -76.004  21.126  1.00 111.36 ? 123 LYS B CG  1 
ATOM 4497 C CD  . LYS B 1 125 ? 74.244 -75.721  21.402  1.00 112.15 ? 123 LYS B CD  1 
ATOM 4498 C CE  . LYS B 1 125 ? 73.570 -76.905  21.978  1.00 111.20 ? 123 LYS B CE  1 
ATOM 4499 N NZ  . LYS B 1 125 ? 72.244 -76.558  22.494  1.00 123.92 ? 123 LYS B NZ  1 
ATOM 4500 N N   . GLY B 1 126 ? 78.747 -73.483  18.732  1.00 112.74 ? 124 GLY B N   1 
ATOM 4501 C CA  . GLY B 1 126 ? 79.330 -72.303  18.121  1.00 110.99 ? 124 GLY B CA  1 
ATOM 4502 C C   . GLY B 1 126 ? 80.852 -72.335  18.190  1.00 115.70 ? 124 GLY B C   1 
ATOM 4503 O O   . GLY B 1 126 ? 81.498 -71.453  17.640  1.00 131.54 ? 124 GLY B O   1 
ATOM 4504 N N   . ASP B 1 127 ? 81.422 -73.374  18.812  1.00 117.81 ? 125 ASP B N   1 
ATOM 4505 C CA  . ASP B 1 127 ? 82.858 -73.573  18.750  1.00 134.85 ? 125 ASP B CA  1 
ATOM 4506 C C   . ASP B 1 127 ? 83.150 -74.302  17.443  1.00 126.22 ? 125 ASP B C   1 
ATOM 4507 O O   . ASP B 1 127 ? 83.696 -75.405  17.445  1.00 131.62 ? 125 ASP B O   1 
ATOM 4508 C CB  . ASP B 1 127 ? 83.381 -74.314  19.972  1.00 145.13 ? 125 ASP B CB  1 
ATOM 4509 C CG  . ASP B 1 127 ? 83.386 -73.539  21.282  1.00 129.74 ? 125 ASP B CG  1 
ATOM 4510 O OD1 . ASP B 1 127 ? 82.323 -72.981  21.644  1.00 125.27 ? 125 ASP B OD1 1 
ATOM 4511 O OD2 . ASP B 1 127 ? 84.444 -73.536  21.941  1.00 105.99 ? 125 ASP B OD2 1 
ATOM 4512 N N   . TYR B 1 128 ? 82.751 -73.688  16.330  1.00 125.61 ? 126 TYR B N   1 
ATOM 4513 C CA  . TYR B 1 128 ? 82.941 -74.314  15.037  1.00 142.62 ? 126 TYR B CA  1 
ATOM 4514 C C   . TYR B 1 128 ? 84.425 -74.533  14.797  1.00 137.90 ? 126 TYR B C   1 
ATOM 4515 O O   . TYR B 1 128 ? 84.824 -75.314  13.949  1.00 148.49 ? 126 TYR B O   1 
ATOM 4516 C CB  . TYR B 1 128 ? 82.265 -73.423  13.994  1.00 149.57 ? 126 TYR B CB  1 
ATOM 4517 C CG  . TYR B 1 128 ? 80.752 -73.471  14.130  1.00 148.22 ? 126 TYR B CG  1 
ATOM 4518 C CD1 . TYR B 1 128 ? 80.088 -74.670  14.383  1.00 140.73 ? 126 TYR B CD1 1 
ATOM 4519 C CD2 . TYR B 1 128 ? 79.999 -72.308  14.091  1.00 140.28 ? 126 TYR B CD2 1 
ATOM 4520 C CE1 . TYR B 1 128 ? 78.713 -74.718  14.536  1.00 123.55 ? 126 TYR B CE1 1 
ATOM 4521 C CE2 . TYR B 1 128 ? 78.626 -72.343  14.247  1.00 134.17 ? 126 TYR B CE2 1 
ATOM 4522 C CZ  . TYR B 1 128 ? 77.985 -73.545  14.473  1.00 122.45 ? 126 TYR B CZ  1 
ATOM 4523 O OH  . TYR B 1 128 ? 76.636 -73.552  14.620  1.00 117.34 ? 126 TYR B OH  1 
ATOM 4524 N N   . PHE B 1 129 ? 85.239 -73.819  15.568  1.00 126.79 ? 127 PHE B N   1 
ATOM 4525 C CA  . PHE B 1 129 ? 86.669 -73.973  15.431  1.00 129.61 ? 127 PHE B CA  1 
ATOM 4526 C C   . PHE B 1 129 ? 87.033 -75.444  15.590  1.00 136.19 ? 127 PHE B C   1 
ATOM 4527 O O   . PHE B 1 129 ? 87.748 -75.988  14.755  1.00 143.21 ? 127 PHE B O   1 
ATOM 4528 C CB  . PHE B 1 129 ? 87.313 -73.058  16.464  1.00 128.37 ? 127 PHE B CB  1 
ATOM 4529 C CG  . PHE B 1 129 ? 88.762 -73.403  16.764  1.00 141.10 ? 127 PHE B CG  1 
ATOM 4530 C CD1 . PHE B 1 129 ? 89.790 -72.933  15.953  1.00 145.31 ? 127 PHE B CD1 1 
ATOM 4531 C CD2 . PHE B 1 129 ? 89.086 -74.186  17.865  1.00 139.24 ? 127 PHE B CD2 1 
ATOM 4532 C CE1 . PHE B 1 129 ? 91.109 -73.235  16.246  1.00 141.53 ? 127 PHE B CE1 1 
ATOM 4533 C CE2 . PHE B 1 129 ? 90.404 -74.493  18.150  1.00 138.89 ? 127 PHE B CE2 1 
ATOM 4534 C CZ  . PHE B 1 129 ? 91.408 -74.017  17.340  1.00 144.41 ? 127 PHE B CZ  1 
ATOM 4535 N N   . HIS B 1 130 ? 86.515 -76.078  16.648  1.00 145.77 ? 128 HIS B N   1 
ATOM 4536 C CA  . HIS B 1 130 ? 86.745 -77.496  16.875  1.00 150.32 ? 128 HIS B CA  1 
ATOM 4537 C C   . HIS B 1 130 ? 86.072 -78.345  15.789  1.00 138.53 ? 128 HIS B C   1 
ATOM 4538 O O   . HIS B 1 130 ? 86.726 -79.193  15.193  1.00 128.39 ? 128 HIS B O   1 
ATOM 4539 C CB  . HIS B 1 130 ? 86.369 -77.895  18.309  1.00 154.53 ? 128 HIS B CB  1 
ATOM 4540 C CG  . HIS B 1 130 ? 86.996 -76.996  19.321  1.00 149.59 ? 128 HIS B CG  1 
ATOM 4541 N ND1 . HIS B 1 130 ? 86.316 -75.925  19.862  1.00 158.72 ? 128 HIS B ND1 1 
ATOM 4542 C CD2 . HIS B 1 130 ? 88.223 -76.968  19.849  1.00 132.77 ? 128 HIS B CD2 1 
ATOM 4543 C CE1 . HIS B 1 130 ? 87.118 -75.279  20.699  1.00 141.52 ? 128 HIS B CE1 1 
ATOM 4544 N NE2 . HIS B 1 130 ? 88.280 -75.901  20.711  1.00 135.14 ? 128 HIS B NE2 1 
ATOM 4545 N N   . VAL B 1 131 ? 84.795 -78.074  15.482  1.00 137.13 ? 129 VAL B N   1 
ATOM 4546 C CA  . VAL B 1 131 ? 84.038 -78.906  14.546  1.00 126.01 ? 129 VAL B CA  1 
ATOM 4547 C C   . VAL B 1 131 ? 83.394 -77.978  13.523  1.00 139.33 ? 129 VAL B C   1 
ATOM 4548 O O   . VAL B 1 131 ? 82.526 -77.190  13.891  1.00 173.28 ? 129 VAL B O   1 
ATOM 4549 C CB  . VAL B 1 131 ? 82.961 -79.794  15.211  1.00 115.82 ? 129 VAL B CB  1 
ATOM 4550 C CG1 . VAL B 1 131 ? 82.208 -80.645  14.200  1.00 119.00 ? 129 VAL B CG1 1 
ATOM 4551 C CG2 . VAL B 1 131 ? 83.555 -80.702  16.275  1.00 121.09 ? 129 VAL B CG2 1 
ATOM 4552 N N   . ARG B 1 132 ? 83.792 -78.109  12.247  1.00 134.03 ? 130 ARG B N   1 
ATOM 4553 C CA  . ARG B 1 132 ? 83.396 -77.152  11.221  1.00 135.56 ? 130 ARG B CA  1 
ATOM 4554 C C   . ARG B 1 132 ? 82.275 -77.726  10.352  1.00 136.48 ? 130 ARG B C   1 
ATOM 4555 O O   . ARG B 1 132 ? 82.427 -78.806  9.779   1.00 134.92 ? 130 ARG B O   1 
ATOM 4556 C CB  . ARG B 1 132 ? 84.596 -76.780  10.343  1.00 126.64 ? 130 ARG B CB  1 
ATOM 4557 C CG  . ARG B 1 132 ? 85.866 -76.553  11.158  1.00 117.62 ? 130 ARG B CG  1 
ATOM 4558 C CD  . ARG B 1 132 ? 87.074 -76.542  10.251  1.00 117.35 ? 130 ARG B CD  1 
ATOM 4559 N NE  . ARG B 1 132 ? 87.060 -75.291  9.488   1.00 124.94 ? 130 ARG B NE  1 
ATOM 4560 C CZ  . ARG B 1 132 ? 87.979 -74.929  8.603   1.00 133.89 ? 130 ARG B CZ  1 
ATOM 4561 N NH1 . ARG B 1 132 ? 88.940 -75.777  8.264   1.00 125.72 ? 130 ARG B NH1 1 
ATOM 4562 N NH2 . ARG B 1 132 ? 87.914 -73.722  8.056   1.00 137.91 ? 130 ARG B NH2 1 
ATOM 4563 N N   . PRO B 1 133 ? 81.117 -77.030  10.225  1.00 128.39 ? 131 PRO B N   1 
ATOM 4564 C CA  . PRO B 1 133 ? 80.038 -77.496  9.355   1.00 119.48 ? 131 PRO B CA  1 
ATOM 4565 C C   . PRO B 1 133 ? 80.489 -77.824  7.930   1.00 113.54 ? 131 PRO B C   1 
ATOM 4566 O O   . PRO B 1 133 ? 80.256 -78.938  7.464   1.00 102.70 ? 131 PRO B O   1 
ATOM 4567 C CB  . PRO B 1 133 ? 79.035 -76.329  9.419   1.00 132.14 ? 131 PRO B CB  1 
ATOM 4568 C CG  . PRO B 1 133 ? 79.250 -75.736  10.792  1.00 125.24 ? 131 PRO B CG  1 
ATOM 4569 C CD  . PRO B 1 133 ? 80.755 -75.802  10.959  1.00 127.87 ? 131 PRO B CD  1 
ATOM 4570 N N   . ASN B 1 134 ? 81.149 -76.872  7.252   1.00 112.72 ? 132 ASN B N   1 
ATOM 4571 C CA  . ASN B 1 134 ? 81.567 -77.088  5.870   1.00 110.83 ? 132 ASN B CA  1 
ATOM 4572 C C   . ASN B 1 134 ? 82.696 -78.112  5.801   1.00 111.72 ? 132 ASN B C   1 
ATOM 4573 O O   . ASN B 1 134 ? 82.572 -79.121  5.117   1.00 102.11 ? 132 ASN B O   1 
ATOM 4574 C CB  . ASN B 1 134 ? 82.064 -75.828  5.158   1.00 108.05 ? 132 ASN B CB  1 
ATOM 4575 C CG  . ASN B 1 134 ? 80.963 -74.907  4.686   1.00 112.44 ? 132 ASN B CG  1 
ATOM 4576 O OD1 . ASN B 1 134 ? 80.970 -73.721  5.031   1.00 116.30 ? 132 ASN B OD1 1 
ATOM 4577 N ND2 . ASN B 1 134 ? 80.042 -75.392  3.864   1.00 120.58 ? 132 ASN B ND2 1 
ATOM 4578 N N   . SER B 1 135 ? 83.796 -77.838  6.514   1.00 124.58 ? 133 SER B N   1 
ATOM 4579 C CA  . SER B 1 135 ? 85.072 -78.463  6.206   1.00 123.04 ? 133 SER B CA  1 
ATOM 4580 C C   . SER B 1 135 ? 85.180 -79.872  6.775   1.00 127.47 ? 133 SER B C   1 
ATOM 4581 O O   . SER B 1 135 ? 85.926 -80.673  6.221   1.00 112.44 ? 133 SER B O   1 
ATOM 4582 C CB  . SER B 1 135 ? 86.200 -77.596  6.654   1.00 122.06 ? 133 SER B CB  1 
ATOM 4583 O OG  . SER B 1 135 ? 86.310 -76.547  5.699   1.00 117.14 ? 133 SER B OG  1 
ATOM 4584 N N   . ASP B 1 136 ? 84.427 -80.166  7.847   1.00 143.33 ? 134 ASP B N   1 
ATOM 4585 C CA  . ASP B 1 136 ? 84.554 -81.428  8.567   1.00 144.77 ? 134 ASP B CA  1 
ATOM 4586 C C   . ASP B 1 136 ? 83.306 -82.302  8.382   1.00 130.14 ? 134 ASP B C   1 
ATOM 4587 O O   . ASP B 1 136 ? 83.404 -83.446  7.917   1.00 120.22 ? 134 ASP B O   1 
ATOM 4588 C CB  . ASP B 1 136 ? 84.870 -81.199  10.040  1.00 148.15 ? 134 ASP B CB  1 
ATOM 4589 C CG  . ASP B 1 136 ? 85.949 -80.170  10.359  1.00 146.70 ? 134 ASP B CG  1 
ATOM 4590 O OD1 . ASP B 1 136 ? 86.947 -80.080  9.591   1.00 118.96 ? 134 ASP B OD1 1 
ATOM 4591 O OD2 . ASP B 1 136 ? 85.789 -79.483  11.396  1.00 151.41 ? 134 ASP B OD2 1 
ATOM 4592 N N   . VAL B 1 137 ? 82.135 -81.775  8.776   1.00 109.75 ? 135 VAL B N   1 
ATOM 4593 C CA  . VAL B 1 137 ? 80.902 -82.548  8.713   1.00 94.02  ? 135 VAL B CA  1 
ATOM 4594 C C   . VAL B 1 137 ? 80.654 -82.909  7.250   1.00 93.61  ? 135 VAL B C   1 
ATOM 4595 O O   . VAL B 1 137 ? 80.340 -84.067  6.955   1.00 93.95  ? 135 VAL B O   1 
ATOM 4596 C CB  . VAL B 1 137 ? 79.662 -81.858  9.318   1.00 85.93  ? 135 VAL B CB  1 
ATOM 4597 C CG1 . VAL B 1 137 ? 78.453 -82.790  9.353   1.00 82.01  ? 135 VAL B CG1 1 
ATOM 4598 C CG2 . VAL B 1 137 ? 79.922 -81.308  10.718  1.00 90.19  ? 135 VAL B CG2 1 
ATOM 4599 N N   . ASN B 1 138 ? 80.887 -81.922  6.363   1.00 88.02  ? 136 ASN B N   1 
ATOM 4600 C CA  . ASN B 1 138 ? 80.514 -81.980  4.955   1.00 91.40  ? 136 ASN B CA  1 
ATOM 4601 C C   . ASN B 1 138 ? 81.718 -82.234  4.035   1.00 93.80  ? 136 ASN B C   1 
ATOM 4602 O O   . ASN B 1 138 ? 81.672 -81.906  2.852   1.00 91.67  ? 136 ASN B O   1 
ATOM 4603 C CB  . ASN B 1 138 ? 79.796 -80.691  4.562   1.00 87.70  ? 136 ASN B CB  1 
ATOM 4604 C CG  . ASN B 1 138 ? 79.075 -80.813  3.240   1.00 84.84  ? 136 ASN B CG  1 
ATOM 4605 O OD1 . ASN B 1 138 ? 78.244 -81.710  3.068   1.00 79.25  ? 136 ASN B OD1 1 
ATOM 4606 N ND2 . ASN B 1 138 ? 79.377 -79.935  2.296   1.00 84.88  ? 136 ASN B ND2 1 
ATOM 4607 N N   . MET B 1 139 ? 82.780 -82.856  4.559   1.00 109.77 ? 137 MET B N   1 
ATOM 4608 C CA  . MET B 1 139 ? 84.011 -83.096  3.816   1.00 116.71 ? 137 MET B CA  1 
ATOM 4609 C C   . MET B 1 139 ? 83.781 -84.145  2.725   1.00 111.65 ? 137 MET B C   1 
ATOM 4610 O O   . MET B 1 139 ? 83.022 -85.082  2.940   1.00 110.09 ? 137 MET B O   1 
ATOM 4611 C CB  . MET B 1 139 ? 85.085 -83.592  4.793   1.00 126.69 ? 137 MET B CB  1 
ATOM 4612 C CG  . MET B 1 139 ? 86.457 -83.804  4.196   1.00 132.26 ? 137 MET B CG  1 
ATOM 4613 S SD  . MET B 1 139 ? 87.539 -84.588  5.409   1.00 133.06 ? 137 MET B SD  1 
ATOM 4614 C CE  . MET B 1 139 ? 87.713 -83.302  6.651   1.00 130.70 ? 137 MET B CE  1 
ATOM 4615 N N   . SER B 1 140 ? 84.440 -83.981  1.565   1.00 113.85 ? 138 SER B N   1 
ATOM 4616 C CA  . SER B 1 140 ? 84.350 -84.904  0.431   1.00 125.39 ? 138 SER B CA  1 
ATOM 4617 C C   . SER B 1 140 ? 82.953 -84.916  -0.209  1.00 122.97 ? 138 SER B C   1 
ATOM 4618 O O   . SER B 1 140 ? 82.624 -85.785  -1.026  1.00 108.38 ? 138 SER B O   1 
ATOM 4619 C CB  . SER B 1 140 ? 84.773 -86.301  0.823   1.00 126.75 ? 138 SER B CB  1 
ATOM 4620 O OG  . SER B 1 140 ? 86.077 -86.333  1.385   1.00 135.20 ? 138 SER B OG  1 
ATOM 4621 N N   . GLN B 1 141 ? 82.144 -83.908  0.130   1.00 122.13 ? 139 GLN B N   1 
ATOM 4622 C CA  . GLN B 1 141 ? 80.717 -83.925  -0.137  1.00 111.40 ? 139 GLN B CA  1 
ATOM 4623 C C   . GLN B 1 141 ? 80.284 -82.585  -0.722  1.00 111.86 ? 139 GLN B C   1 
ATOM 4624 O O   . GLN B 1 141 ? 80.846 -81.543  -0.383  1.00 112.63 ? 139 GLN B O   1 
ATOM 4625 C CB  . GLN B 1 141 ? 79.924 -84.093  1.160   1.00 94.61  ? 139 GLN B CB  1 
ATOM 4626 C CG  . GLN B 1 141 ? 80.065 -85.453  1.830   1.00 86.87  ? 139 GLN B CG  1 
ATOM 4627 C CD  . GLN B 1 141 ? 79.529 -85.434  3.246   1.00 83.74  ? 139 GLN B CD  1 
ATOM 4628 O OE1 . GLN B 1 141 ? 78.315 -85.472  3.484   1.00 86.47  ? 139 GLN B OE1 1 
ATOM 4629 N NE2 . GLN B 1 141 ? 80.434 -85.365  4.210   1.00 84.01  ? 139 GLN B NE2 1 
ATOM 4630 N N   . SER B 1 142 ? 79.269 -82.640  -1.592  1.00 102.53 ? 140 SER B N   1 
ATOM 4631 C CA  . SER B 1 142 ? 78.458 -81.475  -1.892  1.00 92.47  ? 140 SER B CA  1 
ATOM 4632 C C   . SER B 1 142 ? 77.019 -81.757  -1.481  1.00 90.54  ? 140 SER B C   1 
ATOM 4633 O O   . SER B 1 142 ? 76.638 -82.908  -1.268  1.00 76.20  ? 140 SER B O   1 
ATOM 4634 C CB  . SER B 1 142 ? 78.527 -81.102  -3.345  1.00 94.31  ? 140 SER B CB  1 
ATOM 4635 O OG  . SER B 1 142 ? 77.851 -79.870  -3.570  1.00 90.37  ? 140 SER B OG  1 
ATOM 4636 N N   . THR B 1 143 ? 76.230 -80.680  -1.398  1.00 93.80  ? 141 THR B N   1 
ATOM 4637 C CA  . THR B 1 143 ? 74.778 -80.772  -1.411  1.00 88.53  ? 141 THR B CA  1 
ATOM 4638 C C   . THR B 1 143 ? 74.330 -81.834  -2.413  1.00 82.12  ? 141 THR B C   1 
ATOM 4639 O O   . THR B 1 143 ? 73.433 -82.624  -2.127  1.00 81.23  ? 141 THR B O   1 
ATOM 4640 C CB  . THR B 1 143 ? 74.207 -79.409  -1.794  1.00 80.32  ? 141 THR B CB  1 
ATOM 4641 O OG1 . THR B 1 143 ? 74.800 -78.505  -0.861  1.00 87.29  ? 141 THR B OG1 1 
ATOM 4642 C CG2 . THR B 1 143 ? 72.689 -79.401  -1.767  1.00 72.99  ? 141 THR B CG2 1 
ATOM 4643 N N   . ASN B 1 144 ? 74.990 -81.848  -3.575  1.00 71.84  ? 142 ASN B N   1 
ATOM 4644 C CA  . ASN B 1 144 ? 74.465 -82.484  -4.764  1.00 77.32  ? 142 ASN B CA  1 
ATOM 4645 C C   . ASN B 1 144 ? 74.694 -83.994  -4.761  1.00 81.35  ? 142 ASN B C   1 
ATOM 4646 O O   . ASN B 1 144 ? 74.282 -84.651  -5.714  1.00 81.07  ? 142 ASN B O   1 
ATOM 4647 C CB  . ASN B 1 144 ? 75.041 -81.810  -6.002  1.00 78.39  ? 142 ASN B CB  1 
ATOM 4648 C CG  . ASN B 1 144 ? 74.660 -80.350  -6.077  1.00 83.88  ? 142 ASN B CG  1 
ATOM 4649 O OD1 . ASN B 1 144 ? 73.647 -79.931  -5.503  1.00 92.10  ? 142 ASN B OD1 1 
ATOM 4650 N ND2 . ASN B 1 144 ? 75.444 -79.563  -6.799  1.00 86.44  ? 142 ASN B ND2 1 
ATOM 4651 N N   . ASP B 1 145 ? 75.349 -84.535  -3.718  1.00 85.12  ? 143 ASP B N   1 
ATOM 4652 C CA  . ASP B 1 145 ? 75.493 -85.981  -3.559  1.00 83.18  ? 143 ASP B CA  1 
ATOM 4653 C C   . ASP B 1 145 ? 74.933 -86.435  -2.209  1.00 83.44  ? 143 ASP B C   1 
ATOM 4654 O O   . ASP B 1 145 ? 74.318 -87.499  -2.119  1.00 78.38  ? 143 ASP B O   1 
ATOM 4655 C CB  . ASP B 1 145 ? 76.911 -86.487  -3.811  1.00 83.22  ? 143 ASP B CB  1 
ATOM 4656 C CG  . ASP B 1 145 ? 78.020 -85.932  -2.917  1.00 95.90  ? 143 ASP B CG  1 
ATOM 4657 O OD1 . ASP B 1 145 ? 77.811 -84.852  -2.310  1.00 90.65  ? 143 ASP B OD1 1 
ATOM 4658 O OD2 . ASP B 1 145 ? 79.096 -86.589  -2.822  1.00 109.92 ? 143 ASP B OD2 1 
ATOM 4659 N N   . ALA B 1 146 ? 75.140 -85.638  -1.155  1.00 84.85  ? 144 ALA B N   1 
ATOM 4660 C CA  . ALA B 1 146 ? 74.631 -85.995  0.163   1.00 90.12  ? 144 ALA B CA  1 
ATOM 4661 C C   . ALA B 1 146 ? 73.105 -85.999  0.159   1.00 83.68  ? 144 ALA B C   1 
ATOM 4662 O O   . ALA B 1 146 ? 72.480 -86.984  0.544   1.00 79.07  ? 144 ALA B O   1 
ATOM 4663 C CB  . ALA B 1 146 ? 75.157 -85.044  1.220   1.00 97.51  ? 144 ALA B CB  1 
ATOM 4664 N N   . PHE B 1 147 ? 72.521 -84.873  -0.267  1.00 76.80  ? 145 PHE B N   1 
ATOM 4665 C CA  . PHE B 1 147 ? 71.082 -84.692  -0.210  1.00 66.90  ? 145 PHE B CA  1 
ATOM 4666 C C   . PHE B 1 147 ? 70.374 -85.802  -0.995  1.00 72.54  ? 145 PHE B C   1 
ATOM 4667 O O   . PHE B 1 147 ? 69.546 -86.509  -0.430  1.00 68.50  ? 145 PHE B O   1 
ATOM 4668 C CB  . PHE B 1 147 ? 70.739 -83.281  -0.681  1.00 60.19  ? 145 PHE B CB  1 
ATOM 4669 C CG  . PHE B 1 147 ? 69.243 -83.091  -0.852  1.00 66.76  ? 145 PHE B CG  1 
ATOM 4670 C CD1 . PHE B 1 147 ? 68.350 -83.653  0.049   1.00 69.60  ? 145 PHE B CD1 1 
ATOM 4671 C CD2 . PHE B 1 147 ? 68.730 -82.379  -1.925  1.00 74.38  ? 145 PHE B CD2 1 
ATOM 4672 C CE1 . PHE B 1 147 ? 66.987 -83.483  -0.101  1.00 68.91  ? 145 PHE B CE1 1 
ATOM 4673 C CE2 . PHE B 1 147 ? 67.363 -82.223  -2.076  1.00 74.89  ? 145 PHE B CE2 1 
ATOM 4674 C CZ  . PHE B 1 147 ? 66.499 -82.770  -1.161  1.00 73.80  ? 145 PHE B CZ  1 
ATOM 4675 N N   . PRO B 1 148 ? 70.646 -86.003  -2.308  1.00 77.24  ? 146 PRO B N   1 
ATOM 4676 C CA  . PRO B 1 148 ? 70.018 -87.097  -3.058  1.00 78.35  ? 146 PRO B CA  1 
ATOM 4677 C C   . PRO B 1 148 ? 70.268 -88.495  -2.486  1.00 78.26  ? 146 PRO B C   1 
ATOM 4678 O O   . PRO B 1 148 ? 69.344 -89.306  -2.419  1.00 69.23  ? 146 PRO B O   1 
ATOM 4679 C CB  . PRO B 1 148 ? 70.536 -86.968  -4.506  1.00 76.54  ? 146 PRO B CB  1 
ATOM 4680 C CG  . PRO B 1 148 ? 71.682 -85.980  -4.433  1.00 76.38  ? 146 PRO B CG  1 
ATOM 4681 C CD  . PRO B 1 148 ? 71.525 -85.177  -3.150  1.00 76.41  ? 146 PRO B CD  1 
ATOM 4682 N N   . THR B 1 149 ? 71.505 -88.775  -2.056  1.00 80.59  ? 147 THR B N   1 
ATOM 4683 C CA  . THR B 1 149 ? 71.822 -90.091  -1.517  1.00 81.83  ? 147 THR B CA  1 
ATOM 4684 C C   . THR B 1 149 ? 70.931 -90.361  -0.303  1.00 70.08  ? 147 THR B C   1 
ATOM 4685 O O   . THR B 1 149 ? 70.444 -91.480  -0.106  1.00 55.90  ? 147 THR B O   1 
ATOM 4686 C CB  . THR B 1 149 ? 73.309 -90.190  -1.176  1.00 80.20  ? 147 THR B CB  1 
ATOM 4687 O OG1 . THR B 1 149 ? 73.981 -89.943  -2.403  1.00 82.42  ? 147 THR B OG1 1 
ATOM 4688 C CG2 . THR B 1 149 ? 73.715 -91.574  -0.705  1.00 82.65  ? 147 THR B CG2 1 
ATOM 4689 N N   . ALA B 1 150 ? 70.718 -89.317  0.505   1.00 63.84  ? 148 ALA B N   1 
ATOM 4690 C CA  . ALA B 1 150 ? 69.794 -89.412  1.621   1.00 64.62  ? 148 ALA B CA  1 
ATOM 4691 C C   . ALA B 1 150 ? 68.407 -89.744  1.079   1.00 72.84  ? 148 ALA B C   1 
ATOM 4692 O O   . ALA B 1 150 ? 67.806 -90.749  1.470   1.00 78.23  ? 148 ALA B O   1 
ATOM 4693 C CB  . ALA B 1 150 ? 69.794 -88.127  2.426   1.00 60.31  ? 148 ALA B CB  1 
ATOM 4694 N N   . VAL B 1 151 ? 67.945 -88.904  0.137   1.00 74.40  ? 149 VAL B N   1 
ATOM 4695 C CA  . VAL B 1 151 ? 66.613 -89.022  -0.434  1.00 73.48  ? 149 VAL B CA  1 
ATOM 4696 C C   . VAL B 1 151 ? 66.400 -90.457  -0.889  1.00 70.15  ? 149 VAL B C   1 
ATOM 4697 O O   . VAL B 1 151 ? 65.329 -91.011  -0.648  1.00 67.20  ? 149 VAL B O   1 
ATOM 4698 C CB  . VAL B 1 151 ? 66.336 -88.065  -1.606  1.00 76.81  ? 149 VAL B CB  1 
ATOM 4699 C CG1 . VAL B 1 151 ? 64.931 -88.279  -2.160  1.00 79.39  ? 149 VAL B CG1 1 
ATOM 4700 C CG2 . VAL B 1 151 ? 66.550 -86.607  -1.214  1.00 78.64  ? 149 VAL B CG2 1 
ATOM 4701 N N   . HIS B 1 152 ? 67.422 -91.027  -1.550  1.00 66.35  ? 150 HIS B N   1 
ATOM 4702 C CA  . HIS B 1 152 ? 67.340 -92.377  -2.086  1.00 69.31  ? 150 HIS B CA  1 
ATOM 4703 C C   . HIS B 1 152 ? 67.045 -93.386  -0.977  1.00 70.59  ? 150 HIS B C   1 
ATOM 4704 O O   . HIS B 1 152 ? 66.216 -94.278  -1.151  1.00 64.41  ? 150 HIS B O   1 
ATOM 4705 C CB  . HIS B 1 152 ? 68.609 -92.736  -2.869  1.00 68.80  ? 150 HIS B CB  1 
ATOM 4706 C CG  . HIS B 1 152 ? 68.610 -92.225  -4.266  1.00 68.46  ? 150 HIS B CG  1 
ATOM 4707 N ND1 . HIS B 1 152 ? 68.934 -93.017  -5.344  1.00 71.84  ? 150 HIS B ND1 1 
ATOM 4708 C CD2 . HIS B 1 152 ? 68.272 -91.033  -4.774  1.00 76.17  ? 150 HIS B CD2 1 
ATOM 4709 C CE1 . HIS B 1 152 ? 68.820 -92.302  -6.458  1.00 75.95  ? 150 HIS B CE1 1 
ATOM 4710 N NE2 . HIS B 1 152 ? 68.410 -91.094  -6.138  1.00 75.23  ? 150 HIS B NE2 1 
ATOM 4711 N N   . ILE B 1 153 ? 67.723 -93.224  0.163   1.00 73.17  ? 151 ILE B N   1 
ATOM 4712 C CA  . ILE B 1 153 ? 67.576 -94.147  1.276   1.00 74.84  ? 151 ILE B CA  1 
ATOM 4713 C C   . ILE B 1 153 ? 66.224 -93.952  1.960   1.00 71.75  ? 151 ILE B C   1 
ATOM 4714 O O   . ILE B 1 153 ? 65.583 -94.932  2.334   1.00 65.31  ? 151 ILE B O   1 
ATOM 4715 C CB  . ILE B 1 153 ? 68.736 -93.978  2.262   1.00 70.97  ? 151 ILE B CB  1 
ATOM 4716 C CG1 . ILE B 1 153 ? 70.046 -94.380  1.599   1.00 74.45  ? 151 ILE B CG1 1 
ATOM 4717 C CG2 . ILE B 1 153 ? 68.464 -94.754  3.554   1.00 68.84  ? 151 ILE B CG2 1 
ATOM 4718 C CD1 . ILE B 1 153 ? 71.280 -93.933  2.362   1.00 83.19  ? 151 ILE B CD1 1 
ATOM 4719 N N   . ALA B 1 154 ? 65.822 -92.687  2.135   1.00 64.69  ? 152 ALA B N   1 
ATOM 4720 C CA  . ALA B 1 154 ? 64.521 -92.348  2.684   1.00 58.35  ? 152 ALA B CA  1 
ATOM 4721 C C   . ALA B 1 154 ? 63.414 -92.996  1.861   1.00 56.36  ? 152 ALA B C   1 
ATOM 4722 O O   . ALA B 1 154 ? 62.533 -93.692  2.366   1.00 61.47  ? 152 ALA B O   1 
ATOM 4723 C CB  . ALA B 1 154 ? 64.364 -90.853  2.691   1.00 56.98  ? 152 ALA B CB  1 
ATOM 4724 N N   . VAL B 1 155 ? 63.474 -92.734  0.561   1.00 58.89  ? 153 VAL B N   1 
ATOM 4725 C CA  . VAL B 1 155 ? 62.438 -93.191  -0.342  1.00 61.46  ? 153 VAL B CA  1 
ATOM 4726 C C   . VAL B 1 155 ? 62.344 -94.710  -0.248  1.00 59.61  ? 153 VAL B C   1 
ATOM 4727 O O   . VAL B 1 155 ? 61.250 -95.259  -0.161  1.00 59.77  ? 153 VAL B O   1 
ATOM 4728 C CB  . VAL B 1 155 ? 62.713 -92.703  -1.772  1.00 59.76  ? 153 VAL B CB  1 
ATOM 4729 C CG1 . VAL B 1 155 ? 61.738 -93.332  -2.761  1.00 65.88  ? 153 VAL B CG1 1 
ATOM 4730 C CG2 . VAL B 1 155 ? 62.687 -91.182  -1.860  1.00 54.16  ? 153 VAL B CG2 1 
ATOM 4731 N N   . LEU B 1 156 ? 63.497 -95.377  -0.204  1.00 60.20  ? 154 LEU B N   1 
ATOM 4732 C CA  . LEU B 1 156 ? 63.518 -96.831  -0.147  1.00 67.67  ? 154 LEU B CA  1 
ATOM 4733 C C   . LEU B 1 156 ? 62.832 -97.346  1.123   1.00 67.23  ? 154 LEU B C   1 
ATOM 4734 O O   . LEU B 1 156 ? 62.042 -98.290  1.053   1.00 55.10  ? 154 LEU B O   1 
ATOM 4735 C CB  . LEU B 1 156 ? 64.960 -97.318  -0.254  1.00 70.50  ? 154 LEU B CB  1 
ATOM 4736 C CG  . LEU B 1 156 ? 65.545 -97.365  -1.666  1.00 76.53  ? 154 LEU B CG  1 
ATOM 4737 C CD1 . LEU B 1 156 ? 67.045 -97.586  -1.600  1.00 82.95  ? 154 LEU B CD1 1 
ATOM 4738 C CD2 . LEU B 1 156 ? 64.858 -98.452  -2.478  1.00 82.72  ? 154 LEU B CD2 1 
ATOM 4739 N N   . THR B 1 157 ? 63.135 -96.730  2.273   1.00 65.47  ? 155 THR B N   1 
ATOM 4740 C CA  . THR B 1 157 ? 62.579 -97.183  3.539   1.00 68.47  ? 155 THR B CA  1 
ATOM 4741 C C   . THR B 1 157 ? 61.063 -97.051  3.495   1.00 71.43  ? 155 THR B C   1 
ATOM 4742 O O   . THR B 1 157 ? 60.357 -97.956  3.928   1.00 85.56  ? 155 THR B O   1 
ATOM 4743 C CB  . THR B 1 157 ? 63.136 -96.406  4.729   1.00 68.54  ? 155 THR B CB  1 
ATOM 4744 O OG1 . THR B 1 157 ? 62.780 -95.065  4.442   1.00 98.34  ? 155 THR B OG1 1 
ATOM 4745 C CG2 . THR B 1 157 ? 64.639 -96.537  4.888   1.00 73.18  ? 155 THR B CG2 1 
ATOM 4746 N N   . LEU B 1 158 ? 60.573 -95.929  2.960   1.00 58.56  ? 156 LEU B N   1 
ATOM 4747 C CA  . LEU B 1 158 ? 59.146 -95.689  2.963   1.00 60.84  ? 156 LEU B CA  1 
ATOM 4748 C C   . LEU B 1 158 ? 58.435 -96.656  2.019   1.00 63.20  ? 156 LEU B C   1 
ATOM 4749 O O   . LEU B 1 158 ? 57.345 -97.148  2.319   1.00 60.21  ? 156 LEU B O   1 
ATOM 4750 C CB  . LEU B 1 158 ? 58.892 -94.232  2.601   1.00 63.76  ? 156 LEU B CB  1 
ATOM 4751 C CG  . LEU B 1 158 ? 59.258 -93.213  3.685   1.00 67.68  ? 156 LEU B CG  1 
ATOM 4752 C CD1 . LEU B 1 158 ? 58.837 -91.824  3.236   1.00 72.67  ? 156 LEU B CD1 1 
ATOM 4753 C CD2 . LEU B 1 158 ? 58.605 -93.537  5.031   1.00 67.77  ? 156 LEU B CD2 1 
ATOM 4754 N N   . LEU B 1 159 ? 59.066 -96.930  0.880   1.00 65.77  ? 157 LEU B N   1 
ATOM 4755 C CA  . LEU B 1 159 ? 58.473 -97.827  -0.101  1.00 69.82  ? 157 LEU B CA  1 
ATOM 4756 C C   . LEU B 1 159 ? 58.357 -99.222  0.492   1.00 66.06  ? 157 LEU B C   1 
ATOM 4757 O O   . LEU B 1 159 ? 57.393 -99.929  0.197   1.00 61.58  ? 157 LEU B O   1 
ATOM 4758 C CB  . LEU B 1 159 ? 59.257 -97.872  -1.412  1.00 72.57  ? 157 LEU B CB  1 
ATOM 4759 C CG  . LEU B 1 159 ? 59.125 -96.631  -2.302  1.00 72.42  ? 157 LEU B CG  1 
ATOM 4760 C CD1 . LEU B 1 159 ? 60.078 -96.722  -3.455  1.00 74.27  ? 157 LEU B CD1 1 
ATOM 4761 C CD2 . LEU B 1 159 ? 57.717 -96.424  -2.814  1.00 70.98  ? 157 LEU B CD2 1 
ATOM 4762 N N   . ASP B 1 160 ? 59.350 -99.589  1.313   1.00 67.33  ? 158 ASP B N   1 
ATOM 4763 C CA  . ASP B 1 160 ? 59.393 -100.907 1.914   1.00 64.44  ? 158 ASP B CA  1 
ATOM 4764 C C   . ASP B 1 160 ? 58.280 -101.022 2.943   1.00 68.92  ? 158 ASP B C   1 
ATOM 4765 O O   . ASP B 1 160 ? 57.656 -102.081 3.031   1.00 75.12  ? 158 ASP B O   1 
ATOM 4766 C CB  . ASP B 1 160 ? 60.776 -101.234 2.444   1.00 65.18  ? 158 ASP B CB  1 
ATOM 4767 C CG  . ASP B 1 160 ? 61.796 -101.590 1.372   1.00 73.01  ? 158 ASP B CG  1 
ATOM 4768 O OD1 . ASP B 1 160 ? 61.587 -101.220 0.203   1.00 76.68  ? 158 ASP B OD1 1 
ATOM 4769 O OD2 . ASP B 1 160 ? 62.781 -102.266 1.705   1.00 79.93  ? 158 ASP B OD2 1 
ATOM 4770 N N   . HIS B 1 161 ? 58.024 -99.931  3.688   1.00 70.22  ? 159 HIS B N   1 
ATOM 4771 C CA  . HIS B 1 161 ? 56.868 -99.874  4.573   1.00 70.42  ? 159 HIS B CA  1 
ATOM 4772 C C   . HIS B 1 161 ? 55.601 -100.032 3.735   1.00 70.81  ? 159 HIS B C   1 
ATOM 4773 O O   . HIS B 1 161 ? 54.696 -100.788 4.086   1.00 68.00  ? 159 HIS B O   1 
ATOM 4774 C CB  . HIS B 1 161 ? 56.855 -98.579  5.395   1.00 67.64  ? 159 HIS B CB  1 
ATOM 4775 C CG  . HIS B 1 161 ? 57.778 -98.547  6.578   1.00 76.84  ? 159 HIS B CG  1 
ATOM 4776 N ND1 . HIS B 1 161 ? 57.385 -99.081  7.788   1.00 80.86  ? 159 HIS B ND1 1 
ATOM 4777 C CD2 . HIS B 1 161 ? 59.003 -98.016  6.806   1.00 81.08  ? 159 HIS B CD2 1 
ATOM 4778 C CE1 . HIS B 1 161 ? 58.345 -98.902  8.692   1.00 76.23  ? 159 HIS B CE1 1 
ATOM 4779 N NE2 . HIS B 1 161 ? 59.336 -98.257  8.120   1.00 75.06  ? 159 HIS B NE2 1 
ATOM 4780 N N   . LEU B 1 162 ? 55.558 -99.326  2.600   1.00 73.24  ? 160 LEU B N   1 
ATOM 4781 C CA  . LEU B 1 162 ? 54.379 -99.325  1.755   1.00 70.02  ? 160 LEU B CA  1 
ATOM 4782 C C   . LEU B 1 162 ? 54.034 -100.750 1.329   1.00 62.37  ? 160 LEU B C   1 
ATOM 4783 O O   . LEU B 1 162 ? 52.905 -101.196 1.491   1.00 50.99  ? 160 LEU B O   1 
ATOM 4784 C CB  . LEU B 1 162 ? 54.590 -98.383  0.572   1.00 71.46  ? 160 LEU B CB  1 
ATOM 4785 C CG  . LEU B 1 162 ? 53.388 -98.242  -0.371  1.00 72.39  ? 160 LEU B CG  1 
ATOM 4786 C CD1 . LEU B 1 162 ? 52.088 -98.056  0.403   1.00 74.28  ? 160 LEU B CD1 1 
ATOM 4787 C CD2 . LEU B 1 162 ? 53.574 -97.103  -1.363  1.00 66.03  ? 160 LEU B CD2 1 
ATOM 4788 N N   . LEU B 1 163 ? 55.027 -101.474 0.819   1.00 67.60  ? 161 LEU B N   1 
ATOM 4789 C CA  . LEU B 1 163 ? 54.805 -102.793 0.244   1.00 76.26  ? 161 LEU B CA  1 
ATOM 4790 C C   . LEU B 1 163 ? 54.371 -103.806 1.305   1.00 79.07  ? 161 LEU B C   1 
ATOM 4791 O O   . LEU B 1 163 ? 53.660 -104.765 0.991   1.00 68.78  ? 161 LEU B O   1 
ATOM 4792 C CB  . LEU B 1 163 ? 56.096 -103.230 -0.443  1.00 81.25  ? 161 LEU B CB  1 
ATOM 4793 C CG  . LEU B 1 163 ? 56.500 -102.441 -1.693  1.00 81.30  ? 161 LEU B CG  1 
ATOM 4794 C CD1 . LEU B 1 163 ? 58.003 -102.485 -1.865  1.00 81.81  ? 161 LEU B CD1 1 
ATOM 4795 C CD2 . LEU B 1 163 ? 55.819 -102.971 -2.942  1.00 83.07  ? 161 LEU B CD2 1 
ATOM 4796 N N   . GLU B 1 164 ? 54.847 -103.615 2.545   1.00 79.96  ? 162 GLU B N   1 
ATOM 4797 C CA  . GLU B 1 164 ? 54.362 -104.390 3.674   1.00 81.99  ? 162 GLU B CA  1 
ATOM 4798 C C   . GLU B 1 164 ? 52.862 -104.137 3.815   1.00 79.86  ? 162 GLU B C   1 
ATOM 4799 O O   . GLU B 1 164 ? 52.073 -105.079 3.850   1.00 86.52  ? 162 GLU B O   1 
ATOM 4800 C CB  . GLU B 1 164 ? 55.051 -103.982 4.976   1.00 92.25  ? 162 GLU B CB  1 
ATOM 4801 C CG  . GLU B 1 164 ? 56.562 -104.182 4.974   1.00 100.86 ? 162 GLU B CG  1 
ATOM 4802 C CD  . GLU B 1 164 ? 57.123 -105.292 5.831   1.00 110.27 ? 162 GLU B CD  1 
ATOM 4803 O OE1 . GLU B 1 164 ? 56.395 -106.141 6.404   1.00 117.25 ? 162 GLU B OE1 1 
ATOM 4804 O OE2 . GLU B 1 164 ? 58.365 -105.238 5.920   1.00 113.87 ? 162 GLU B OE2 1 
ATOM 4805 N N   . THR B 1 165 ? 52.481 -102.852 3.851   1.00 70.97  ? 163 THR B N   1 
ATOM 4806 C CA  . THR B 1 165 ? 51.106 -102.456 4.106   1.00 68.95  ? 163 THR B CA  1 
ATOM 4807 C C   . THR B 1 165 ? 50.191 -102.970 2.995   1.00 70.38  ? 163 THR B C   1 
ATOM 4808 O O   . THR B 1 165 ? 49.023 -103.306 3.233   1.00 64.38  ? 163 THR B O   1 
ATOM 4809 C CB  . THR B 1 165 ? 51.016 -100.935 4.233   1.00 66.03  ? 163 THR B CB  1 
ATOM 4810 O OG1 . THR B 1 165 ? 51.781 -100.613 5.386   1.00 70.27  ? 163 THR B OG1 1 
ATOM 4811 C CG2 . THR B 1 165 ? 49.590 -100.445 4.434   1.00 68.59  ? 163 THR B CG2 1 
ATOM 4812 N N   . MET B 1 166 ? 50.732 -102.974 1.774   1.00 70.47  ? 164 MET B N   1 
ATOM 4813 C CA  . MET B 1 166 ? 49.964 -103.337 0.600   1.00 77.66  ? 164 MET B CA  1 
ATOM 4814 C C   . MET B 1 166 ? 49.851 -104.850 0.539   1.00 83.07  ? 164 MET B C   1 
ATOM 4815 O O   . MET B 1 166 ? 48.800 -105.375 0.173   1.00 77.62  ? 164 MET B O   1 
ATOM 4816 C CB  . MET B 1 166 ? 50.637 -102.820 -0.676  1.00 78.67  ? 164 MET B CB  1 
ATOM 4817 C CG  . MET B 1 166 ? 50.585 -101.317 -0.827  1.00 77.90  ? 164 MET B CG  1 
ATOM 4818 S SD  . MET B 1 166 ? 51.536 -100.751 -2.247  1.00 73.18  ? 164 MET B SD  1 
ATOM 4819 C CE  . MET B 1 166 ? 50.454 -101.393 -3.532  1.00 78.68  ? 164 MET B CE  1 
ATOM 4820 N N   . GLU B 1 167 ? 50.957 -105.526 0.885   1.00 90.02  ? 165 GLU B N   1 
ATOM 4821 C CA  . GLU B 1 167 ? 50.971 -106.976 0.932   1.00 85.44  ? 165 GLU B CA  1 
ATOM 4822 C C   . GLU B 1 167 ? 49.852 -107.388 1.881   1.00 78.75  ? 165 GLU B C   1 
ATOM 4823 O O   . GLU B 1 167 ? 49.084 -108.281 1.542   1.00 77.13  ? 165 GLU B O   1 
ATOM 4824 C CB  . GLU B 1 167 ? 52.358 -107.525 1.274   1.00 91.41  ? 165 GLU B CB  1 
ATOM 4825 C CG  . GLU B 1 167 ? 52.479 -109.035 1.049   1.00 105.06 ? 165 GLU B CG  1 
ATOM 4826 C CD  . GLU B 1 167 ? 52.579 -109.490 -0.401  1.00 111.45 ? 165 GLU B CD  1 
ATOM 4827 O OE1 . GLU B 1 167 ? 53.726 -109.401 -0.880  1.00 113.97 ? 165 GLU B OE1 1 
ATOM 4828 O OE2 . GLU B 1 167 ? 51.588 -109.910 -1.060  1.00 103.06 ? 165 GLU B OE2 1 
ATOM 4829 N N   . ARG B 1 168 ? 49.727 -106.679 3.016   1.00 75.86  ? 166 ARG B N   1 
ATOM 4830 C CA  . ARG B 1 168 ? 48.665 -106.938 3.979   1.00 84.94  ? 166 ARG B CA  1 
ATOM 4831 C C   . ARG B 1 168 ? 47.307 -106.611 3.357   1.00 86.59  ? 166 ARG B C   1 
ATOM 4832 O O   . ARG B 1 168 ? 46.363 -107.383 3.505   1.00 89.97  ? 166 ARG B O   1 
ATOM 4833 C CB  . ARG B 1 168 ? 48.878 -106.227 5.323   1.00 90.38  ? 166 ARG B CB  1 
ATOM 4834 C CG  . ARG B 1 168 ? 49.572 -107.052 6.406   1.00 97.58  ? 166 ARG B CG  1 
ATOM 4835 C CD  . ARG B 1 168 ? 49.854 -106.301 7.725   1.00 99.89  ? 166 ARG B CD  1 
ATOM 4836 N NE  . ARG B 1 168 ? 50.959 -105.329 7.637   1.00 110.79 ? 166 ARG B NE  1 
ATOM 4837 C CZ  . ARG B 1 168 ? 50.921 -103.983 7.807   1.00 113.42 ? 166 ARG B CZ  1 
ATOM 4838 N NH1 . ARG B 1 168 ? 49.815 -103.355 8.188   1.00 115.41 ? 166 ARG B NH1 1 
ATOM 4839 N NH2 . ARG B 1 168 ? 51.997 -103.247 7.567   1.00 103.31 ? 166 ARG B NH2 1 
ATOM 4840 N N   . MET B 1 169 ? 47.213 -105.482 2.646   1.00 87.94  ? 167 MET B N   1 
ATOM 4841 C CA  . MET B 1 169 ? 45.959 -105.093 2.017   1.00 86.62  ? 167 MET B CA  1 
ATOM 4842 C C   . MET B 1 169 ? 45.520 -106.144 0.987   1.00 79.51  ? 167 MET B C   1 
ATOM 4843 O O   . MET B 1 169 ? 44.340 -106.491 0.907   1.00 80.80  ? 167 MET B O   1 
ATOM 4844 C CB  . MET B 1 169 ? 46.078 -103.709 1.366   1.00 89.27  ? 167 MET B CB  1 
ATOM 4845 C CG  . MET B 1 169 ? 44.722 -103.093 0.985   1.00 84.96  ? 167 MET B CG  1 
ATOM 4846 S SD  . MET B 1 169 ? 44.780 -101.354 0.506   1.00 75.64  ? 167 MET B SD  1 
ATOM 4847 C CE  . MET B 1 169 ? 46.017 -101.313 -0.802  1.00 75.31  ? 167 MET B CE  1 
ATOM 4848 N N   . ARG B 1 170 ? 46.463 -106.670 0.198   1.00 68.32  ? 168 ARG B N   1 
ATOM 4849 C CA  . ARG B 1 170 ? 46.140 -107.659 -0.820  1.00 70.11  ? 168 ARG B CA  1 
ATOM 4850 C C   . ARG B 1 170 ? 45.557 -108.898 -0.158  1.00 75.66  ? 168 ARG B C   1 
ATOM 4851 O O   . ARG B 1 170 ? 44.604 -109.509 -0.650  1.00 80.66  ? 168 ARG B O   1 
ATOM 4852 C CB  . ARG B 1 170 ? 47.410 -108.125 -1.535  1.00 76.27  ? 168 ARG B CB  1 
ATOM 4853 C CG  . ARG B 1 170 ? 47.241 -109.048 -2.732  1.00 77.60  ? 168 ARG B CG  1 
ATOM 4854 C CD  . ARG B 1 170 ? 48.404 -110.034 -2.766  1.00 91.07  ? 168 ARG B CD  1 
ATOM 4855 N NE  . ARG B 1 170 ? 48.126 -111.126 -1.821  1.00 109.91 ? 168 ARG B NE  1 
ATOM 4856 C CZ  . ARG B 1 170 ? 47.331 -112.176 -2.050  1.00 103.96 ? 168 ARG B CZ  1 
ATOM 4857 N NH1 . ARG B 1 170 ? 46.973 -112.475 -3.289  1.00 107.63 ? 168 ARG B NH1 1 
ATOM 4858 N NH2 . ARG B 1 170 ? 46.962 -112.980 -1.060  1.00 91.77  ? 168 ARG B NH2 1 
ATOM 4859 N N   . ASP B 1 171 ? 46.183 -109.274 0.961   1.00 78.84  ? 169 ASP B N   1 
ATOM 4860 C CA  . ASP B 1 171 ? 45.751 -110.431 1.724   1.00 81.34  ? 169 ASP B CA  1 
ATOM 4861 C C   . ASP B 1 171 ? 44.296 -110.213 2.137   1.00 81.11  ? 169 ASP B C   1 
ATOM 4862 O O   . ASP B 1 171 ? 43.487 -111.128 2.047   1.00 79.68  ? 169 ASP B O   1 
ATOM 4863 C CB  . ASP B 1 171 ? 46.701 -110.716 2.880   1.00 82.53  ? 169 ASP B CB  1 
ATOM 4864 C CG  . ASP B 1 171 ? 48.063 -111.298 2.508   1.00 84.06  ? 169 ASP B CG  1 
ATOM 4865 O OD1 . ASP B 1 171 ? 48.237 -111.713 1.337   1.00 72.18  ? 169 ASP B OD1 1 
ATOM 4866 O OD2 . ASP B 1 171 ? 48.953 -111.325 3.395   1.00 95.48  ? 169 ASP B OD2 1 
ATOM 4867 N N   . ALA B 1 172 ? 43.966 -108.979 2.536   1.00 85.24  ? 170 ALA B N   1 
ATOM 4868 C CA  . ALA B 1 172 ? 42.641 -108.651 3.041   1.00 87.28  ? 170 ALA B CA  1 
ATOM 4869 C C   . ALA B 1 172 ? 41.588 -108.834 1.953   1.00 80.91  ? 170 ALA B C   1 
ATOM 4870 O O   . ALA B 1 172 ? 40.551 -109.457 2.180   1.00 90.23  ? 170 ALA B O   1 
ATOM 4871 C CB  . ALA B 1 172 ? 42.620 -107.236 3.579   1.00 92.57  ? 170 ALA B CB  1 
ATOM 4872 N N   . PHE B 1 173 ? 41.855 -108.267 0.778   1.00 71.20  ? 171 PHE B N   1 
ATOM 4873 C CA  . PHE B 1 173 ? 40.939 -108.403 -0.338  1.00 76.61  ? 171 PHE B CA  1 
ATOM 4874 C C   . PHE B 1 173 ? 40.776 -109.873 -0.726  1.00 82.18  ? 171 PHE B C   1 
ATOM 4875 O O   . PHE B 1 173 ? 39.665 -110.322 -1.005  1.00 89.12  ? 171 PHE B O   1 
ATOM 4876 C CB  . PHE B 1 173 ? 41.465 -107.560 -1.498  1.00 79.41  ? 171 PHE B CB  1 
ATOM 4877 C CG  . PHE B 1 173 ? 40.997 -106.117 -1.456  1.00 73.03  ? 171 PHE B CG  1 
ATOM 4878 C CD1 . PHE B 1 173 ? 39.744 -105.774 -1.948  1.00 67.58  ? 171 PHE B CD1 1 
ATOM 4879 C CD2 . PHE B 1 173 ? 41.812 -105.113 -0.946  1.00 70.57  ? 171 PHE B CD2 1 
ATOM 4880 C CE1 . PHE B 1 173 ? 39.312 -104.458 -1.904  1.00 71.24  ? 171 PHE B CE1 1 
ATOM 4881 C CE2 . PHE B 1 173 ? 41.374 -103.798 -0.915  1.00 69.85  ? 171 PHE B CE2 1 
ATOM 4882 C CZ  . PHE B 1 173 ? 40.120 -103.473 -1.381  1.00 67.25  ? 171 PHE B CZ  1 
ATOM 4883 N N   . ALA B 1 174 ? 41.897 -110.604 -0.745  1.00 82.60  ? 172 ALA B N   1 
ATOM 4884 C CA  . ALA B 1 174 ? 41.922 -112.003 -1.145  1.00 86.10  ? 172 ALA B CA  1 
ATOM 4885 C C   . ALA B 1 174 ? 40.970 -112.856 -0.297  1.00 80.48  ? 172 ALA B C   1 
ATOM 4886 O O   . ALA B 1 174 ? 40.323 -113.757 -0.837  1.00 76.69  ? 172 ALA B O   1 
ATOM 4887 C CB  . ALA B 1 174 ? 43.349 -112.514 -1.077  1.00 90.09  ? 172 ALA B CB  1 
ATOM 4888 N N   . GLU B 1 175 ? 40.897 -112.576 1.019   1.00 74.25  ? 173 GLU B N   1 
ATOM 4889 C CA  . GLU B 1 175 ? 39.970 -113.254 1.915   1.00 81.54  ? 173 GLU B CA  1 
ATOM 4890 C C   . GLU B 1 175 ? 38.532 -113.001 1.452   1.00 83.39  ? 173 GLU B C   1 
ATOM 4891 O O   . GLU B 1 175 ? 37.718 -113.921 1.346   1.00 86.88  ? 173 GLU B O   1 
ATOM 4892 C CB  . GLU B 1 175 ? 40.061 -112.796 3.373   1.00 90.18  ? 173 GLU B CB  1 
ATOM 4893 C CG  . GLU B 1 175 ? 41.316 -113.224 4.127   1.00 107.80 ? 173 GLU B CG  1 
ATOM 4894 C CD  . GLU B 1 175 ? 41.662 -112.363 5.347   1.00 125.23 ? 173 GLU B CD  1 
ATOM 4895 O OE1 . GLU B 1 175 ? 40.910 -111.426 5.722   1.00 120.72 ? 173 GLU B OE1 1 
ATOM 4896 O OE2 . GLU B 1 175 ? 42.749 -112.608 5.917   1.00 130.63 ? 173 GLU B OE2 1 
ATOM 4897 N N   . LYS B 1 176 ? 38.222 -111.738 1.148   1.00 81.35  ? 174 LYS B N   1 
ATOM 4898 C CA  . LYS B 1 176 ? 36.872 -111.360 0.774   1.00 78.94  ? 174 LYS B CA  1 
ATOM 4899 C C   . LYS B 1 176 ? 36.504 -111.960 -0.575  1.00 80.01  ? 174 LYS B C   1 
ATOM 4900 O O   . LYS B 1 176 ? 35.319 -112.118 -0.865  1.00 88.80  ? 174 LYS B O   1 
ATOM 4901 C CB  . LYS B 1 176 ? 36.762 -109.834 0.769   1.00 79.97  ? 174 LYS B CB  1 
ATOM 4902 C CG  . LYS B 1 176 ? 37.005 -109.239 2.146   1.00 85.01  ? 174 LYS B CG  1 
ATOM 4903 C CD  . LYS B 1 176 ? 35.919 -109.625 3.142   1.00 85.52  ? 174 LYS B CD  1 
ATOM 4904 C CE  . LYS B 1 176 ? 36.280 -109.328 4.533   1.00 83.33  ? 174 LYS B CE  1 
ATOM 4905 N NZ  . LYS B 1 176 ? 35.077 -109.293 5.362   1.00 91.54  ? 174 LYS B NZ  1 
ATOM 4906 N N   . ALA B 1 177 ? 37.521 -112.268 -1.394  1.00 75.40  ? 175 ALA B N   1 
ATOM 4907 C CA  . ALA B 1 177 ? 37.305 -112.970 -2.649  1.00 76.90  ? 175 ALA B CA  1 
ATOM 4908 C C   . ALA B 1 177 ? 36.726 -114.350 -2.360  1.00 84.26  ? 175 ALA B C   1 
ATOM 4909 O O   . ALA B 1 177 ? 35.725 -114.764 -2.958  1.00 80.35  ? 175 ALA B O   1 
ATOM 4910 C CB  . ALA B 1 177 ? 38.600 -113.068 -3.418  1.00 76.01  ? 175 ALA B CB  1 
ATOM 4911 N N   . LYS B 1 178 ? 37.369 -115.040 -1.410  1.00 86.64  ? 176 LYS B N   1 
ATOM 4912 C CA  . LYS B 1 178 ? 36.991 -116.394 -1.046  1.00 86.92  ? 176 LYS B CA  1 
ATOM 4913 C C   . LYS B 1 178 ? 35.656 -116.349 -0.304  1.00 87.16  ? 176 LYS B C   1 
ATOM 4914 O O   . LYS B 1 178 ? 34.745 -117.102 -0.634  1.00 101.62 ? 176 LYS B O   1 
ATOM 4915 C CB  . LYS B 1 178 ? 38.166 -117.048 -0.313  1.00 86.98  ? 176 LYS B CB  1 
ATOM 4916 C CG  . LYS B 1 178 ? 39.410 -117.071 -1.186  1.00 100.48 ? 176 LYS B CG  1 
ATOM 4917 C CD  . LYS B 1 178 ? 40.626 -117.767 -0.605  1.00 115.14 ? 176 LYS B CD  1 
ATOM 4918 C CE  . LYS B 1 178 ? 41.765 -117.624 -1.561  1.00 122.02 ? 176 LYS B CE  1 
ATOM 4919 N NZ  . LYS B 1 178 ? 43.019 -118.087 -0.967  1.00 125.02 ? 176 LYS B NZ  1 
ATOM 4920 N N   . ALA B 1 179 ? 35.525 -115.428 0.656   1.00 81.11  ? 177 ALA B N   1 
ATOM 4921 C CA  . ALA B 1 179 ? 34.317 -115.324 1.460   1.00 79.52  ? 177 ALA B CA  1 
ATOM 4922 C C   . ALA B 1 179 ? 33.080 -115.100 0.587   1.00 81.19  ? 177 ALA B C   1 
ATOM 4923 O O   . ALA B 1 179 ? 32.020 -115.659 0.865   1.00 80.77  ? 177 ALA B O   1 
ATOM 4924 C CB  . ALA B 1 179 ? 34.479 -114.218 2.478   1.00 81.00  ? 177 ALA B CB  1 
ATOM 4925 N N   . PHE B 1 180 ? 33.216 -114.278 -0.461  1.00 90.46  ? 178 PHE B N   1 
ATOM 4926 C CA  . PHE B 1 180 ? 32.083 -113.839 -1.262  1.00 93.03  ? 178 PHE B CA  1 
ATOM 4927 C C   . PHE B 1 180 ? 31.983 -114.618 -2.571  1.00 100.07 ? 178 PHE B C   1 
ATOM 4928 O O   . PHE B 1 180 ? 31.164 -114.277 -3.424  1.00 109.40 ? 178 PHE B O   1 
ATOM 4929 C CB  . PHE B 1 180 ? 32.206 -112.355 -1.616  1.00 89.76  ? 178 PHE B CB  1 
ATOM 4930 C CG  . PHE B 1 180 ? 32.165 -111.386 -0.443  1.00 84.60  ? 178 PHE B CG  1 
ATOM 4931 C CD1 . PHE B 1 180 ? 31.460 -111.679 0.717   1.00 81.34  ? 178 PHE B CD1 1 
ATOM 4932 C CD2 . PHE B 1 180 ? 32.817 -110.165 -0.521  1.00 79.55  ? 178 PHE B CD2 1 
ATOM 4933 C CE1 . PHE B 1 180 ? 31.413 -110.772 1.763   1.00 83.61  ? 178 PHE B CE1 1 
ATOM 4934 C CE2 . PHE B 1 180 ? 32.777 -109.269 0.532   1.00 75.19  ? 178 PHE B CE2 1 
ATOM 4935 C CZ  . PHE B 1 180 ? 32.083 -109.576 1.675   1.00 76.79  ? 178 PHE B CZ  1 
ATOM 4936 N N   . ASP B 1 181 ? 32.796 -115.671 -2.727  1.00 98.60  ? 179 ASP B N   1 
ATOM 4937 C CA  . ASP B 1 181 ? 32.816 -116.429 -3.968  1.00 95.80  ? 179 ASP B CA  1 
ATOM 4938 C C   . ASP B 1 181 ? 31.428 -116.969 -4.322  1.00 90.71  ? 179 ASP B C   1 
ATOM 4939 O O   . ASP B 1 181 ? 31.074 -116.969 -5.499  1.00 86.35  ? 179 ASP B O   1 
ATOM 4940 C CB  . ASP B 1 181 ? 33.816 -117.572 -3.921  1.00 100.11 ? 179 ASP B CB  1 
ATOM 4941 C CG  . ASP B 1 181 ? 34.033 -118.330 -5.228  1.00 99.02  ? 179 ASP B CG  1 
ATOM 4942 O OD1 . ASP B 1 181 ? 33.399 -117.963 -6.249  1.00 81.65  ? 179 ASP B OD1 1 
ATOM 4943 O OD2 . ASP B 1 181 ? 34.826 -119.301 -5.215  1.00 99.95  ? 179 ASP B OD2 1 
ATOM 4944 N N   . PRO B 1 182 ? 30.623 -117.490 -3.359  1.00 88.74  ? 180 PRO B N   1 
ATOM 4945 C CA  . PRO B 1 182 ? 29.318 -118.069 -3.685  1.00 89.44  ? 180 PRO B CA  1 
ATOM 4946 C C   . PRO B 1 182 ? 28.138 -117.116 -3.833  1.00 90.45  ? 180 PRO B C   1 
ATOM 4947 O O   . PRO B 1 182 ? 27.048 -117.566 -4.192  1.00 103.89 ? 180 PRO B O   1 
ATOM 4948 C CB  . PRO B 1 182 ? 29.119 -118.992 -2.489  1.00 88.00  ? 180 PRO B CB  1 
ATOM 4949 C CG  . PRO B 1 182 ? 29.649 -118.162 -1.350  1.00 87.07  ? 180 PRO B CG  1 
ATOM 4950 C CD  . PRO B 1 182 ? 30.942 -117.620 -1.928  1.00 85.43  ? 180 PRO B CD  1 
ATOM 4951 N N   . TYR B 1 183 ? 28.337 -115.820 -3.554  1.00 87.49  ? 181 TYR B N   1 
ATOM 4952 C CA  . TYR B 1 183 ? 27.233 -114.868 -3.602  1.00 94.46  ? 181 TYR B CA  1 
ATOM 4953 C C   . TYR B 1 183 ? 27.005 -114.355 -5.026  1.00 95.78  ? 181 TYR B C   1 
ATOM 4954 O O   . TYR B 1 183 ? 27.903 -113.777 -5.632  1.00 111.80 ? 181 TYR B O   1 
ATOM 4955 C CB  . TYR B 1 183 ? 27.533 -113.754 -2.598  1.00 98.71  ? 181 TYR B CB  1 
ATOM 4956 C CG  . TYR B 1 183 ? 27.671 -114.240 -1.161  1.00 105.98 ? 181 TYR B CG  1 
ATOM 4957 C CD1 . TYR B 1 183 ? 26.932 -115.320 -0.699  1.00 111.41 ? 181 TYR B CD1 1 
ATOM 4958 C CD2 . TYR B 1 183 ? 28.557 -113.641 -0.274  1.00 104.17 ? 181 TYR B CD2 1 
ATOM 4959 C CE1 . TYR B 1 183 ? 27.048 -115.769 0.605   1.00 107.13 ? 181 TYR B CE1 1 
ATOM 4960 C CE2 . TYR B 1 183 ? 28.692 -114.087 1.030   1.00 106.10 ? 181 TYR B CE2 1 
ATOM 4961 C CZ  . TYR B 1 183 ? 27.926 -115.150 1.474   1.00 103.18 ? 181 TYR B CZ  1 
ATOM 4962 O OH  . TYR B 1 183 ? 28.011 -115.623 2.749   1.00 85.03  ? 181 TYR B OH  1 
ATOM 4963 N N   . ILE B 1 184 ? 25.784 -114.550 -5.542  1.00 82.99  ? 182 ILE B N   1 
ATOM 4964 C CA  . ILE B 1 184 ? 25.423 -114.140 -6.892  1.00 88.13  ? 182 ILE B CA  1 
ATOM 4965 C C   . ILE B 1 184 ? 24.838 -112.724 -6.850  1.00 90.95  ? 182 ILE B C   1 
ATOM 4966 O O   . ILE B 1 184 ? 24.140 -112.367 -5.904  1.00 87.21  ? 182 ILE B O   1 
ATOM 4967 C CB  . ILE B 1 184 ? 24.445 -115.162 -7.517  1.00 94.27  ? 182 ILE B CB  1 
ATOM 4968 C CG1 . ILE B 1 184 ? 24.276 -114.984 -9.031  1.00 89.57  ? 182 ILE B CG1 1 
ATOM 4969 C CG2 . ILE B 1 184 ? 23.082 -115.154 -6.817  1.00 95.64  ? 182 ILE B CG2 1 
ATOM 4970 C CD1 . ILE B 1 184 ? 25.438 -115.520 -9.848  1.00 91.76  ? 182 ILE B CD1 1 
ATOM 4971 N N   . LYS B 1 185 ? 25.121 -111.922 -7.888  1.00 95.53  ? 183 LYS B N   1 
ATOM 4972 C CA  . LYS B 1 185 ? 24.588 -110.569 -8.010  1.00 98.70  ? 183 LYS B CA  1 
ATOM 4973 C C   . LYS B 1 185 ? 24.506 -110.169 -9.485  1.00 99.75  ? 183 LYS B C   1 
ATOM 4974 O O   . LYS B 1 185 ? 24.953 -110.916 -10.351 1.00 85.68  ? 183 LYS B O   1 
ATOM 4975 C CB  . LYS B 1 185 ? 25.459 -109.550 -7.269  1.00 98.09  ? 183 LYS B CB  1 
ATOM 4976 C CG  . LYS B 1 185 ? 26.959 -109.642 -7.559  1.00 102.33 ? 183 LYS B CG  1 
ATOM 4977 C CD  . LYS B 1 185 ? 27.747 -108.386 -7.195  1.00 105.55 ? 183 LYS B CD  1 
ATOM 4978 C CE  . LYS B 1 185 ? 27.615 -107.310 -8.231  1.00 108.10 ? 183 LYS B CE  1 
ATOM 4979 N NZ  . LYS B 1 185 ? 28.169 -106.029 -7.786  1.00 108.36 ? 183 LYS B NZ  1 
ATOM 4980 N N   . MET B 1 186 ? 23.934 -108.988 -9.760  1.00 97.13  ? 184 MET B N   1 
ATOM 4981 C CA  . MET B 1 186 ? 23.915 -108.460 -11.115 1.00 94.68  ? 184 MET B CA  1 
ATOM 4982 C C   . MET B 1 186 ? 25.193 -107.683 -11.407 1.00 99.29  ? 184 MET B C   1 
ATOM 4983 O O   . MET B 1 186 ? 25.468 -106.670 -10.773 1.00 119.52 ? 184 MET B O   1 
ATOM 4984 C CB  . MET B 1 186 ? 22.729 -107.522 -11.352 1.00 97.29  ? 184 MET B CB  1 
ATOM 4985 C CG  . MET B 1 186 ? 21.506 -108.201 -11.932 1.00 103.85 ? 184 MET B CG  1 
ATOM 4986 S SD  . MET B 1 186 ? 21.768 -109.013 -13.524 1.00 98.33  ? 184 MET B SD  1 
ATOM 4987 C CE  . MET B 1 186 ? 21.912 -110.696 -12.919 1.00 82.83  ? 184 MET B CE  1 
ATOM 4988 N N   . GLY B 1 187 ? 25.960 -108.159 -12.388 1.00 90.88  ? 185 GLY B N   1 
ATOM 4989 C CA  . GLY B 1 187 ? 26.983 -107.334 -13.001 1.00 85.71  ? 185 GLY B CA  1 
ATOM 4990 C C   . GLY B 1 187 ? 26.344 -106.102 -13.640 1.00 84.70  ? 185 GLY B C   1 
ATOM 4991 O O   . GLY B 1 187 ? 25.253 -106.191 -14.207 1.00 84.89  ? 185 GLY B O   1 
ATOM 4992 N N   . ARG B 1 188 ? 27.003 -104.945 -13.500 1.00 80.68  ? 186 ARG B N   1 
ATOM 4993 C CA  . ARG B 1 188 ? 26.531 -103.740 -14.155 1.00 80.67  ? 186 ARG B CA  1 
ATOM 4994 C C   . ARG B 1 188 ? 27.601 -103.189 -15.086 1.00 84.86  ? 186 ARG B C   1 
ATOM 4995 O O   . ARG B 1 188 ? 28.796 -103.302 -14.824 1.00 88.73  ? 186 ARG B O   1 
ATOM 4996 C CB  . ARG B 1 188 ? 26.143 -102.690 -13.120 1.00 88.24  ? 186 ARG B CB  1 
ATOM 4997 C CG  . ARG B 1 188 ? 24.993 -103.153 -12.240 1.00 95.31  ? 186 ARG B CG  1 
ATOM 4998 C CD  . ARG B 1 188 ? 24.415 -102.010 -11.440 1.00 100.38 ? 186 ARG B CD  1 
ATOM 4999 N NE  . ARG B 1 188 ? 23.615 -102.455 -10.294 1.00 100.25 ? 186 ARG B NE  1 
ATOM 5000 C CZ  . ARG B 1 188 ? 24.046 -103.189 -9.275  1.00 86.74  ? 186 ARG B CZ  1 
ATOM 5001 N NH1 . ARG B 1 188 ? 25.286 -103.671 -9.248  1.00 84.67  ? 186 ARG B NH1 1 
ATOM 5002 N NH2 . ARG B 1 188 ? 23.203 -103.457 -8.299  1.00 79.96  ? 186 ARG B NH2 1 
ATOM 5003 N N   . ILE B 1 189 ? 27.128 -102.533 -16.145 1.00 84.86  ? 187 ILE B N   1 
ATOM 5004 C CA  . ILE B 1 189 ? 27.927 -102.141 -17.292 1.00 77.81  ? 187 ILE B CA  1 
ATOM 5005 C C   . ILE B 1 189 ? 27.318 -100.846 -17.813 1.00 73.98  ? 187 ILE B C   1 
ATOM 5006 O O   . ILE B 1 189 ? 26.146 -100.828 -18.184 1.00 77.13  ? 187 ILE B O   1 
ATOM 5007 C CB  . ILE B 1 189 ? 27.913 -103.314 -18.288 1.00 86.17  ? 187 ILE B CB  1 
ATOM 5008 C CG1 . ILE B 1 189 ? 29.171 -104.124 -18.115 1.00 92.11  ? 187 ILE B CG1 1 
ATOM 5009 C CG2 . ILE B 1 189 ? 27.695 -102.922 -19.753 1.00 86.46  ? 187 ILE B CG2 1 
ATOM 5010 C CD1 . ILE B 1 189 ? 29.135 -105.424 -18.893 1.00 112.69 ? 187 ILE B CD1 1 
ATOM 5011 N N   . HIS B 1 190 ? 28.087 -99.754  -17.737 1.00 67.59  ? 188 HIS B N   1 
ATOM 5012 C CA  . HIS B 1 190 ? 27.573 -98.405  -17.958 1.00 67.23  ? 188 HIS B CA  1 
ATOM 5013 C C   . HIS B 1 190 ? 26.548 -98.053  -16.879 1.00 65.17  ? 188 HIS B C   1 
ATOM 5014 O O   . HIS B 1 190 ? 25.777 -97.113  -17.057 1.00 54.34  ? 188 HIS B O   1 
ATOM 5015 C CB  . HIS B 1 190 ? 26.930 -98.223  -19.344 1.00 67.47  ? 188 HIS B CB  1 
ATOM 5016 C CG  . HIS B 1 190 ? 27.692 -98.733  -20.540 1.00 65.07  ? 188 HIS B CG  1 
ATOM 5017 N ND1 . HIS B 1 190 ? 27.728 -98.031  -21.722 1.00 63.44  ? 188 HIS B ND1 1 
ATOM 5018 C CD2 . HIS B 1 190 ? 28.409 -99.840  -20.770 1.00 66.19  ? 188 HIS B CD2 1 
ATOM 5019 C CE1 . HIS B 1 190 ? 28.439 -98.699  -22.612 1.00 65.14  ? 188 HIS B CE1 1 
ATOM 5020 N NE2 . HIS B 1 190 ? 28.874 -99.798  -22.051 1.00 63.19  ? 188 HIS B NE2 1 
ATOM 5021 N N   . LEU B 1 191 ? 26.580 -98.815  -15.768 1.00 65.79  ? 189 LEU B N   1 
ATOM 5022 C CA  . LEU B 1 191 ? 25.626 -98.761  -14.668 1.00 66.33  ? 189 LEU B CA  1 
ATOM 5023 C C   . LEU B 1 191 ? 24.299 -99.418  -15.056 1.00 79.70  ? 189 LEU B C   1 
ATOM 5024 O O   . LEU B 1 191 ? 23.388 -99.507  -14.224 1.00 94.12  ? 189 LEU B O   1 
ATOM 5025 C CB  . LEU B 1 191 ? 25.430 -97.345  -14.124 1.00 61.74  ? 189 LEU B CB  1 
ATOM 5026 C CG  . LEU B 1 191 ? 26.675 -96.699  -13.503 1.00 58.08  ? 189 LEU B CG  1 
ATOM 5027 C CD1 . LEU B 1 191 ? 26.443 -95.263  -13.058 1.00 59.64  ? 189 LEU B CD1 1 
ATOM 5028 C CD2 . LEU B 1 191 ? 27.197 -97.534  -12.347 1.00 56.82  ? 189 LEU B CD2 1 
ATOM 5029 N N   . GLN B 1 192 ? 24.198 -99.915  -16.297 1.00 76.92  ? 190 GLN B N   1 
ATOM 5030 C CA  . GLN B 1 192 ? 23.018 -100.645 -16.723 1.00 76.15  ? 190 GLN B CA  1 
ATOM 5031 C C   . GLN B 1 192 ? 23.176 -102.121 -16.364 1.00 86.02  ? 190 GLN B C   1 
ATOM 5032 O O   . GLN B 1 192 ? 24.283 -102.668 -16.427 1.00 79.38  ? 190 GLN B O   1 
ATOM 5033 C CB  . GLN B 1 192 ? 22.779 -100.494 -18.224 1.00 78.89  ? 190 GLN B CB  1 
ATOM 5034 C CG  . GLN B 1 192 ? 22.538 -99.064  -18.701 1.00 73.58  ? 190 GLN B CG  1 
ATOM 5035 C CD  . GLN B 1 192 ? 21.450 -98.355  -17.934 1.00 62.57  ? 190 GLN B CD  1 
ATOM 5036 O OE1 . GLN B 1 192 ? 21.734 -97.465  -17.133 1.00 69.56  ? 190 GLN B OE1 1 
ATOM 5037 N NE2 . GLN B 1 192 ? 20.208 -98.770  -18.122 1.00 58.64  ? 190 GLN B NE2 1 
ATOM 5038 N N   . ASP B 1 193 ? 22.054 -102.748 -15.981 1.00 95.11  ? 191 ASP B N   1 
ATOM 5039 C CA  . ASP B 1 193 ? 22.053 -104.141 -15.550 1.00 89.87  ? 191 ASP B CA  1 
ATOM 5040 C C   . ASP B 1 193 ? 22.470 -105.010 -16.728 1.00 86.76  ? 191 ASP B C   1 
ATOM 5041 O O   . ASP B 1 193 ? 21.890 -104.897 -17.811 1.00 90.72  ? 191 ASP B O   1 
ATOM 5042 C CB  . ASP B 1 193 ? 20.694 -104.582 -15.033 1.00 84.06  ? 191 ASP B CB  1 
ATOM 5043 C CG  . ASP B 1 193 ? 19.973 -103.543 -14.189 1.00 91.95  ? 191 ASP B CG  1 
ATOM 5044 O OD1 . ASP B 1 193 ? 20.544 -102.443 -13.982 1.00 100.68 ? 191 ASP B OD1 1 
ATOM 5045 O OD2 . ASP B 1 193 ? 18.825 -103.824 -13.785 1.00 88.55  ? 191 ASP B OD2 1 
ATOM 5046 N N   . ALA B 1 194 ? 23.470 -105.871 -16.510 1.00 81.44  ? 192 ALA B N   1 
ATOM 5047 C CA  . ALA B 1 194 ? 24.004 -106.664 -17.604 1.00 80.68  ? 192 ALA B CA  1 
ATOM 5048 C C   . ALA B 1 194 ? 23.781 -108.154 -17.342 1.00 83.04  ? 192 ALA B C   1 
ATOM 5049 O O   . ALA B 1 194 ? 22.734 -108.690 -17.678 1.00 85.72  ? 192 ALA B O   1 
ATOM 5050 C CB  . ALA B 1 194 ? 25.460 -106.322 -17.825 1.00 79.39  ? 192 ALA B CB  1 
ATOM 5051 N N   . VAL B 1 195 ? 24.765 -108.830 -16.754 1.00 81.20  ? 193 VAL B N   1 
ATOM 5052 C CA  . VAL B 1 195 ? 24.743 -110.281 -16.669 1.00 79.87  ? 193 VAL B CA  1 
ATOM 5053 C C   . VAL B 1 195 ? 25.188 -110.694 -15.270 1.00 79.52  ? 193 VAL B C   1 
ATOM 5054 O O   . VAL B 1 195 ? 25.895 -109.942 -14.595 1.00 82.19  ? 193 VAL B O   1 
ATOM 5055 C CB  . VAL B 1 195 ? 25.642 -110.937 -17.737 1.00 86.94  ? 193 VAL B CB  1 
ATOM 5056 C CG1 . VAL B 1 195 ? 25.160 -110.693 -19.150 1.00 89.50  ? 193 VAL B CG1 1 
ATOM 5057 C CG2 . VAL B 1 195 ? 27.072 -110.446 -17.664 1.00 93.26  ? 193 VAL B CG2 1 
ATOM 5058 N N   . PRO B 1 196 ? 24.767 -111.883 -14.794 1.00 71.97  ? 194 PRO B N   1 
ATOM 5059 C CA  . PRO B 1 196 ? 25.178 -112.379 -13.483 1.00 73.96  ? 194 PRO B CA  1 
ATOM 5060 C C   . PRO B 1 196 ? 26.686 -112.495 -13.305 1.00 75.54  ? 194 PRO B C   1 
ATOM 5061 O O   . PRO B 1 196 ? 27.397 -112.823 -14.255 1.00 78.66  ? 194 PRO B O   1 
ATOM 5062 C CB  . PRO B 1 196 ? 24.492 -113.735 -13.397 1.00 77.33  ? 194 PRO B CB  1 
ATOM 5063 C CG  . PRO B 1 196 ? 23.292 -113.597 -14.301 1.00 87.18  ? 194 PRO B CG  1 
ATOM 5064 C CD  . PRO B 1 196 ? 23.802 -112.764 -15.462 1.00 81.42  ? 194 PRO B CD  1 
ATOM 5065 N N   . ILE B 1 197 ? 27.123 -112.227 -12.066 1.00 73.77  ? 195 ILE B N   1 
ATOM 5066 C CA  . ILE B 1 197 ? 28.505 -112.321 -11.628 1.00 75.03  ? 195 ILE B CA  1 
ATOM 5067 C C   . ILE B 1 197 ? 28.471 -112.601 -10.126 1.00 72.46  ? 195 ILE B C   1 
ATOM 5068 O O   . ILE B 1 197 ? 27.498 -112.256 -9.453  1.00 68.97  ? 195 ILE B O   1 
ATOM 5069 C CB  . ILE B 1 197 ? 29.271 -111.023 -11.968 1.00 86.23  ? 195 ILE B CB  1 
ATOM 5070 C CG1 . ILE B 1 197 ? 30.776 -111.169 -11.745 1.00 90.41  ? 195 ILE B CG1 1 
ATOM 5071 C CG2 . ILE B 1 197 ? 28.716 -109.822 -11.198 1.00 93.46  ? 195 ILE B CG2 1 
ATOM 5072 C CD1 . ILE B 1 197 ? 31.583 -109.928 -12.067 1.00 93.89  ? 195 ILE B CD1 1 
ATOM 5073 N N   . ARG B 1 198 ? 29.527 -113.220 -9.592  1.00 71.25  ? 196 ARG B N   1 
ATOM 5074 C CA  . ARG B 1 198 ? 29.590 -113.429 -8.156  1.00 80.67  ? 196 ARG B CA  1 
ATOM 5075 C C   . ARG B 1 198 ? 30.424 -112.329 -7.500  1.00 74.79  ? 196 ARG B C   1 
ATOM 5076 O O   . ARG B 1 198 ? 31.521 -111.995 -7.961  1.00 66.41  ? 196 ARG B O   1 
ATOM 5077 C CB  . ARG B 1 198 ? 30.232 -114.762 -7.777  1.00 94.24  ? 196 ARG B CB  1 
ATOM 5078 C CG  . ARG B 1 198 ? 29.675 -116.042 -8.378  1.00 98.15  ? 196 ARG B CG  1 
ATOM 5079 C CD  . ARG B 1 198 ? 30.913 -116.722 -8.936  1.00 105.18 ? 196 ARG B CD  1 
ATOM 5080 N NE  . ARG B 1 198 ? 30.810 -118.177 -9.010  1.00 114.26 ? 196 ARG B NE  1 
ATOM 5081 C CZ  . ARG B 1 198 ? 31.730 -118.932 -9.597  1.00 128.81 ? 196 ARG B CZ  1 
ATOM 5082 N NH1 . ARG B 1 198 ? 32.794 -118.382 -10.147 1.00 111.66 ? 196 ARG B NH1 1 
ATOM 5083 N NH2 . ARG B 1 198 ? 31.587 -120.243 -9.642  1.00 153.70 ? 196 ARG B NH2 1 
ATOM 5084 N N   . LEU B 1 199 ? 29.915 -111.827 -6.371  1.00 64.77  ? 197 LEU B N   1 
ATOM 5085 C CA  . LEU B 1 199 ? 30.571 -110.763 -5.638  1.00 68.10  ? 197 LEU B CA  1 
ATOM 5086 C C   . LEU B 1 199 ? 32.060 -111.058 -5.497  1.00 69.61  ? 197 LEU B C   1 
ATOM 5087 O O   . LEU B 1 199 ? 32.885 -110.164 -5.639  1.00 74.24  ? 197 LEU B O   1 
ATOM 5088 C CB  . LEU B 1 199 ? 29.903 -110.609 -4.278  1.00 72.42  ? 197 LEU B CB  1 
ATOM 5089 C CG  . LEU B 1 199 ? 30.386 -109.419 -3.444  1.00 79.71  ? 197 LEU B CG  1 
ATOM 5090 C CD1 . LEU B 1 199 ? 30.033 -108.097 -4.118  1.00 81.37  ? 197 LEU B CD1 1 
ATOM 5091 C CD2 . LEU B 1 199 ? 29.785 -109.496 -2.056  1.00 90.02  ? 197 LEU B CD2 1 
ATOM 5092 N N   . GLY B 1 200 ? 32.393 -112.320 -5.219  1.00 74.16  ? 198 GLY B N   1 
ATOM 5093 C CA  . GLY B 1 200 ? 33.769 -112.744 -5.009  1.00 75.16  ? 198 GLY B CA  1 
ATOM 5094 C C   . GLY B 1 200 ? 34.652 -112.562 -6.241  1.00 78.88  ? 198 GLY B C   1 
ATOM 5095 O O   . GLY B 1 200 ? 35.852 -112.320 -6.098  1.00 90.57  ? 198 GLY B O   1 
ATOM 5096 N N   . GLN B 1 201 ? 34.072 -112.695 -7.442  1.00 75.33  ? 199 GLN B N   1 
ATOM 5097 C CA  . GLN B 1 201 ? 34.813 -112.449 -8.672  1.00 79.60  ? 199 GLN B CA  1 
ATOM 5098 C C   . GLN B 1 201 ? 35.224 -110.982 -8.759  1.00 82.77  ? 199 GLN B C   1 
ATOM 5099 O O   . GLN B 1 201 ? 36.285 -110.684 -9.302  1.00 75.62  ? 199 GLN B O   1 
ATOM 5100 C CB  . GLN B 1 201 ? 34.017 -112.756 -9.937  1.00 80.51  ? 199 GLN B CB  1 
ATOM 5101 C CG  . GLN B 1 201 ? 34.137 -114.189 -10.438 1.00 77.57  ? 199 GLN B CG  1 
ATOM 5102 C CD  . GLN B 1 201 ? 32.892 -114.639 -11.166 1.00 80.42  ? 199 GLN B CD  1 
ATOM 5103 O OE1 . GLN B 1 201 ? 31.793 -114.129 -10.928 1.00 79.35  ? 199 GLN B OE1 1 
ATOM 5104 N NE2 . GLN B 1 201 ? 33.034 -115.607 -12.057 1.00 88.02  ? 199 GLN B NE2 1 
ATOM 5105 N N   . GLU B 1 202 ? 34.361 -110.081 -8.258  1.00 81.63  ? 200 GLU B N   1 
ATOM 5106 C CA  . GLU B 1 202 ? 34.670 -108.663 -8.204  1.00 76.47  ? 200 GLU B CA  1 
ATOM 5107 C C   . GLU B 1 202 ? 35.835 -108.426 -7.260  1.00 71.29  ? 200 GLU B C   1 
ATOM 5108 O O   . GLU B 1 202 ? 36.673 -107.572 -7.530  1.00 87.08  ? 200 GLU B O   1 
ATOM 5109 C CB  . GLU B 1 202 ? 33.525 -107.781 -7.711  1.00 76.57  ? 200 GLU B CB  1 
ATOM 5110 C CG  . GLU B 1 202 ? 32.340 -107.814 -8.663  1.00 86.63  ? 200 GLU B CG  1 
ATOM 5111 C CD  . GLU B 1 202 ? 31.262 -106.811 -8.325  1.00 92.16  ? 200 GLU B CD  1 
ATOM 5112 O OE1 . GLU B 1 202 ? 30.684 -106.854 -7.217  1.00 75.47  ? 200 GLU B OE1 1 
ATOM 5113 O OE2 . GLU B 1 202 ? 31.012 -105.982 -9.215  1.00 105.27 ? 200 GLU B OE2 1 
ATOM 5114 N N   . PHE B 1 203 ? 35.874 -109.163 -6.151  1.00 62.91  ? 201 PHE B N   1 
ATOM 5115 C CA  . PHE B 1 203 ? 36.911 -108.930 -5.164  1.00 70.78  ? 201 PHE B CA  1 
ATOM 5116 C C   . PHE B 1 203 ? 38.218 -109.577 -5.619  1.00 83.64  ? 201 PHE B C   1 
ATOM 5117 O O   . PHE B 1 203 ? 39.294 -109.091 -5.261  1.00 89.87  ? 201 PHE B O   1 
ATOM 5118 C CB  . PHE B 1 203 ? 36.477 -109.362 -3.766  1.00 70.97  ? 201 PHE B CB  1 
ATOM 5119 C CG  . PHE B 1 203 ? 35.720 -108.289 -3.000  1.00 69.62  ? 201 PHE B CG  1 
ATOM 5120 C CD1 . PHE B 1 203 ? 34.379 -108.036 -3.270  1.00 70.48  ? 201 PHE B CD1 1 
ATOM 5121 C CD2 . PHE B 1 203 ? 36.355 -107.537 -2.017  1.00 67.04  ? 201 PHE B CD2 1 
ATOM 5122 C CE1 . PHE B 1 203 ? 33.694 -107.052 -2.579  1.00 72.37  ? 201 PHE B CE1 1 
ATOM 5123 C CE2 . PHE B 1 203 ? 35.665 -106.556 -1.327  1.00 67.80  ? 201 PHE B CE2 1 
ATOM 5124 C CZ  . PHE B 1 203 ? 34.338 -106.320 -1.601  1.00 72.52  ? 201 PHE B CZ  1 
ATOM 5125 N N   . GLU B 1 204 ? 38.141 -110.649 -6.424  1.00 85.40  ? 202 GLU B N   1 
ATOM 5126 C CA  . GLU B 1 204 ? 39.353 -111.205 -7.009  1.00 86.35  ? 202 GLU B CA  1 
ATOM 5127 C C   . GLU B 1 204 ? 39.948 -110.155 -7.947  1.00 76.51  ? 202 GLU B C   1 
ATOM 5128 O O   . GLU B 1 204 ? 41.160 -109.938 -7.976  1.00 72.69  ? 202 GLU B O   1 
ATOM 5129 C CB  . GLU B 1 204 ? 39.088 -112.536 -7.725  1.00 92.18  ? 202 GLU B CB  1 
ATOM 5130 C CG  . GLU B 1 204 ? 40.352 -113.277 -8.162  1.00 99.25  ? 202 GLU B CG  1 
ATOM 5131 C CD  . GLU B 1 204 ? 41.332 -113.672 -7.059  1.00 109.98 ? 202 GLU B CD  1 
ATOM 5132 O OE1 . GLU B 1 204 ? 42.548 -113.391 -7.197  1.00 102.86 ? 202 GLU B OE1 1 
ATOM 5133 O OE2 . GLU B 1 204 ? 40.879 -114.263 -6.045  1.00 122.89 ? 202 GLU B OE2 1 
ATOM 5134 N N   . ALA B 1 205 ? 39.074 -109.487 -8.702  1.00 69.68  ? 203 ALA B N   1 
ATOM 5135 C CA  . ALA B 1 205 ? 39.500 -108.435 -9.604  1.00 69.84  ? 203 ALA B CA  1 
ATOM 5136 C C   . ALA B 1 205 ? 40.300 -107.380 -8.849  1.00 63.10  ? 203 ALA B C   1 
ATOM 5137 O O   . ALA B 1 205 ? 41.384 -106.972 -9.275  1.00 66.52  ? 203 ALA B O   1 
ATOM 5138 C CB  . ALA B 1 205 ? 38.295 -107.827 -10.277 1.00 76.49  ? 203 ALA B CB  1 
ATOM 5139 N N   . TYR B 1 206 ? 39.748 -106.930 -7.726  1.00 56.15  ? 204 TYR B N   1 
ATOM 5140 C CA  . TYR B 1 206 ? 40.456 -105.981 -6.895  1.00 55.30  ? 204 TYR B CA  1 
ATOM 5141 C C   . TYR B 1 206 ? 41.787 -106.606 -6.469  1.00 57.46  ? 204 TYR B C   1 
ATOM 5142 O O   . TYR B 1 206 ? 42.822 -105.951 -6.537  1.00 57.81  ? 204 TYR B O   1 
ATOM 5143 C CB  . TYR B 1 206 ? 39.566 -105.540 -5.728  1.00 53.25  ? 204 TYR B CB  1 
ATOM 5144 C CG  . TYR B 1 206 ? 38.199 -104.997 -6.113  1.00 54.71  ? 204 TYR B CG  1 
ATOM 5145 C CD1 . TYR B 1 206 ? 37.962 -104.406 -7.344  1.00 65.82  ? 204 TYR B CD1 1 
ATOM 5146 C CD2 . TYR B 1 206 ? 37.133 -105.089 -5.237  1.00 61.74  ? 204 TYR B CD2 1 
ATOM 5147 C CE1 . TYR B 1 206 ? 36.710 -103.909 -7.681  1.00 78.35  ? 204 TYR B CE1 1 
ATOM 5148 C CE2 . TYR B 1 206 ? 35.873 -104.604 -5.561  1.00 70.65  ? 204 TYR B CE2 1 
ATOM 5149 C CZ  . TYR B 1 206 ? 35.653 -104.010 -6.789  1.00 77.34  ? 204 TYR B CZ  1 
ATOM 5150 O OH  . TYR B 1 206 ? 34.395 -103.542 -7.084  1.00 75.50  ? 204 TYR B OH  1 
ATOM 5151 N N   . THR B 1 207 ? 41.774 -107.877 -6.051  1.00 60.16  ? 205 THR B N   1 
ATOM 5152 C CA  . THR B 1 207 ? 42.964 -108.502 -5.488  1.00 68.38  ? 205 THR B CA  1 
ATOM 5153 C C   . THR B 1 207 ? 44.123 -108.487 -6.486  1.00 69.66  ? 205 THR B C   1 
ATOM 5154 O O   . THR B 1 207 ? 45.276 -108.335 -6.092  1.00 68.35  ? 205 THR B O   1 
ATOM 5155 C CB  . THR B 1 207 ? 42.649 -109.929 -5.038  1.00 74.18  ? 205 THR B CB  1 
ATOM 5156 O OG1 . THR B 1 207 ? 41.665 -109.807 -4.015  1.00 75.34  ? 205 THR B OG1 1 
ATOM 5157 C CG2 . THR B 1 207 ? 43.867 -110.650 -4.483  1.00 74.86  ? 205 THR B CG2 1 
ATOM 5158 N N   . ARG B 1 208 ? 43.821 -108.663 -7.775  1.00 69.87  ? 206 ARG B N   1 
ATOM 5159 C CA  . ARG B 1 208 ? 44.862 -108.895 -8.763  1.00 72.57  ? 206 ARG B CA  1 
ATOM 5160 C C   . ARG B 1 208 ? 45.461 -107.568 -9.226  1.00 70.46  ? 206 ARG B C   1 
ATOM 5161 O O   . ARG B 1 208 ? 46.667 -107.477 -9.441  1.00 69.53  ? 206 ARG B O   1 
ATOM 5162 C CB  . ARG B 1 208 ? 44.284 -109.777 -9.874  1.00 77.71  ? 206 ARG B CB  1 
ATOM 5163 C CG  . ARG B 1 208 ? 43.853 -111.109 -9.281  1.00 85.54  ? 206 ARG B CG  1 
ATOM 5164 C CD  . ARG B 1 208 ? 43.452 -112.158 -10.281 1.00 93.25  ? 206 ARG B CD  1 
ATOM 5165 N NE  . ARG B 1 208 ? 44.618 -112.810 -10.886 1.00 105.32 ? 206 ARG B NE  1 
ATOM 5166 C CZ  . ARG B 1 208 ? 45.038 -112.626 -12.134 1.00 120.92 ? 206 ARG B CZ  1 
ATOM 5167 N NH1 . ARG B 1 208 ? 44.520 -111.672 -12.887 1.00 124.55 ? 206 ARG B NH1 1 
ATOM 5168 N NH2 . ARG B 1 208 ? 45.994 -113.391 -12.630 1.00 125.10 ? 206 ARG B NH2 1 
ATOM 5169 N N   . VAL B 1 209 ? 44.627 -106.533 -9.361  1.00 68.28  ? 207 VAL B N   1 
ATOM 5170 C CA  . VAL B 1 209 ? 45.135 -105.218 -9.719  1.00 71.97  ? 207 VAL B CA  1 
ATOM 5171 C C   . VAL B 1 209 ? 46.135 -104.784 -8.643  1.00 66.22  ? 207 VAL B C   1 
ATOM 5172 O O   . VAL B 1 209 ? 47.152 -104.146 -8.930  1.00 69.17  ? 207 VAL B O   1 
ATOM 5173 C CB  . VAL B 1 209 ? 43.997 -104.194 -9.922  1.00 76.48  ? 207 VAL B CB  1 
ATOM 5174 C CG1 . VAL B 1 209 ? 43.315 -103.819 -8.612  1.00 79.09  ? 207 VAL B CG1 1 
ATOM 5175 C CG2 . VAL B 1 209 ? 44.461 -102.938 -10.666 1.00 73.75  ? 207 VAL B CG2 1 
ATOM 5176 N N   . ILE B 1 210 ? 45.856 -105.178 -7.399  1.00 57.08  ? 208 ILE B N   1 
ATOM 5177 C CA  . ILE B 1 210 ? 46.725 -104.839 -6.289  1.00 59.94  ? 208 ILE B CA  1 
ATOM 5178 C C   . ILE B 1 210 ? 48.007 -105.656 -6.385  1.00 59.70  ? 208 ILE B C   1 
ATOM 5179 O O   . ILE B 1 210 ? 49.086 -105.108 -6.174  1.00 59.59  ? 208 ILE B O   1 
ATOM 5180 C CB  . ILE B 1 210 ? 45.991 -105.019 -4.948  1.00 60.13  ? 208 ILE B CB  1 
ATOM 5181 C CG1 . ILE B 1 210 ? 44.812 -104.029 -4.854  1.00 59.10  ? 208 ILE B CG1 1 
ATOM 5182 C CG2 . ILE B 1 210 ? 46.957 -104.888 -3.766  1.00 55.59  ? 208 ILE B CG2 1 
ATOM 5183 C CD1 . ILE B 1 210 ? 43.765 -104.386 -3.819  1.00 59.63  ? 208 ILE B CD1 1 
ATOM 5184 N N   . GLU B 1 211 ? 47.887 -106.947 -6.729  1.00 67.54  ? 209 GLU B N   1 
ATOM 5185 C CA  . GLU B 1 211 ? 49.062 -107.777 -6.963  1.00 68.62  ? 209 GLU B CA  1 
ATOM 5186 C C   . GLU B 1 211 ? 50.003 -107.025 -7.902  1.00 66.81  ? 209 GLU B C   1 
ATOM 5187 O O   . GLU B 1 211 ? 51.200 -106.924 -7.636  1.00 73.05  ? 209 GLU B O   1 
ATOM 5188 C CB  . GLU B 1 211 ? 48.696 -109.168 -7.487  1.00 66.42  ? 209 GLU B CB  1 
ATOM 5189 C CG  . GLU B 1 211 ? 48.139 -110.094 -6.408  1.00 77.64  ? 209 GLU B CG  1 
ATOM 5190 C CD  . GLU B 1 211 ? 47.373 -111.331 -6.868  1.00 90.17  ? 209 GLU B CD  1 
ATOM 5191 O OE1 . GLU B 1 211 ? 47.269 -111.530 -8.101  1.00 110.40 ? 209 GLU B OE1 1 
ATOM 5192 O OE2 . GLU B 1 211 ? 46.858 -112.090 -6.003  1.00 86.74  ? 209 GLU B OE2 1 
ATOM 5193 N N   . ARG B 1 212 ? 49.424 -106.442 -8.958  1.00 65.81  ? 210 ARG B N   1 
ATOM 5194 C CA  . ARG B 1 212 ? 50.188 -105.791 -10.009 1.00 67.76  ? 210 ARG B CA  1 
ATOM 5195 C C   . ARG B 1 212 ? 50.794 -104.493 -9.490  1.00 70.84  ? 210 ARG B C   1 
ATOM 5196 O O   . ARG B 1 212 ? 51.941 -104.180 -9.799  1.00 80.59  ? 210 ARG B O   1 
ATOM 5197 C CB  . ARG B 1 212 ? 49.336 -105.549 -11.262 1.00 67.46  ? 210 ARG B CB  1 
ATOM 5198 C CG  . ARG B 1 212 ? 49.174 -106.802 -12.112 1.00 73.31  ? 210 ARG B CG  1 
ATOM 5199 C CD  . ARG B 1 212 ? 48.634 -106.544 -13.509 1.00 74.13  ? 210 ARG B CD  1 
ATOM 5200 N NE  . ARG B 1 212 ? 47.284 -105.974 -13.531 1.00 71.33  ? 210 ARG B NE  1 
ATOM 5201 C CZ  . ARG B 1 212 ? 46.150 -106.595 -13.218 1.00 67.19  ? 210 ARG B CZ  1 
ATOM 5202 N NH1 . ARG B 1 212 ? 46.152 -107.865 -12.847 1.00 64.41  ? 210 ARG B NH1 1 
ATOM 5203 N NH2 . ARG B 1 212 ? 45.008 -105.930 -13.293 1.00 64.55  ? 210 ARG B NH2 1 
ATOM 5204 N N   . ASP B 1 213 ? 50.021 -103.736 -8.715  1.00 72.02  ? 211 ASP B N   1 
ATOM 5205 C CA  . ASP B 1 213 ? 50.541 -102.503 -8.154  1.00 78.46  ? 211 ASP B CA  1 
ATOM 5206 C C   . ASP B 1 213 ? 51.792 -102.789 -7.331  1.00 72.12  ? 211 ASP B C   1 
ATOM 5207 O O   . ASP B 1 213 ? 52.761 -102.035 -7.407  1.00 62.91  ? 211 ASP B O   1 
ATOM 5208 C CB  . ASP B 1 213 ? 49.482 -101.789 -7.340  1.00 90.07  ? 211 ASP B CB  1 
ATOM 5209 C CG  . ASP B 1 213 ? 48.460 -101.049 -8.181  1.00 97.64  ? 211 ASP B CG  1 
ATOM 5210 O OD1 . ASP B 1 213 ? 48.894 -100.444 -9.197  1.00 101.21 ? 211 ASP B OD1 1 
ATOM 5211 O OD2 . ASP B 1 213 ? 47.267 -101.052 -7.780  1.00 99.27  ? 211 ASP B OD2 1 
ATOM 5212 N N   . ILE B 1 214 ? 51.755 -103.882 -6.560  1.00 69.65  ? 212 ILE B N   1 
ATOM 5213 C CA  . ILE B 1 214 ? 52.865 -104.222 -5.691  1.00 68.64  ? 212 ILE B CA  1 
ATOM 5214 C C   . ILE B 1 214 ? 54.113 -104.465 -6.537  1.00 75.67  ? 212 ILE B C   1 
ATOM 5215 O O   . ILE B 1 214 ? 55.181 -103.956 -6.190  1.00 74.74  ? 212 ILE B O   1 
ATOM 5216 C CB  . ILE B 1 214 ? 52.533 -105.419 -4.789  1.00 62.79  ? 212 ILE B CB  1 
ATOM 5217 C CG1 . ILE B 1 214 ? 51.530 -105.034 -3.730  1.00 67.18  ? 212 ILE B CG1 1 
ATOM 5218 C CG2 . ILE B 1 214 ? 53.801 -105.979 -4.155  1.00 63.28  ? 212 ILE B CG2 1 
ATOM 5219 C CD1 . ILE B 1 214 ? 50.968 -106.195 -2.927  1.00 74.90  ? 212 ILE B CD1 1 
ATOM 5220 N N   . GLN B 1 215 ? 53.958 -105.224 -7.636  1.00 70.82  ? 213 GLN B N   1 
ATOM 5221 C CA  . GLN B 1 215 ? 55.078 -105.565 -8.497  1.00 76.89  ? 213 GLN B CA  1 
ATOM 5222 C C   . GLN B 1 215 ? 55.689 -104.305 -9.113  1.00 73.66  ? 213 GLN B C   1 
ATOM 5223 O O   . GLN B 1 215 ? 56.909 -104.210 -9.225  1.00 85.58  ? 213 GLN B O   1 
ATOM 5224 C CB  . GLN B 1 215 ? 54.704 -106.495 -9.652  1.00 88.76  ? 213 GLN B CB  1 
ATOM 5225 C CG  . GLN B 1 215 ? 54.399 -107.938 -9.277  1.00 103.96 ? 213 GLN B CG  1 
ATOM 5226 C CD  . GLN B 1 215 ? 53.545 -108.607 -10.336 1.00 132.99 ? 213 GLN B CD  1 
ATOM 5227 O OE1 . GLN B 1 215 ? 52.493 -109.189 -10.046 1.00 155.22 ? 213 GLN B OE1 1 
ATOM 5228 N NE2 . GLN B 1 215 ? 53.953 -108.474 -11.590 1.00 134.81 ? 213 GLN B NE2 1 
ATOM 5229 N N   . ARG B 1 216 ? 54.846 -103.350 -9.527  1.00 66.04  ? 214 ARG B N   1 
ATOM 5230 C CA  . ARG B 1 216 ? 55.323 -102.132 -10.165 1.00 69.47  ? 214 ARG B CA  1 
ATOM 5231 C C   . ARG B 1 216 ? 56.056 -101.232 -9.168  1.00 76.54  ? 214 ARG B C   1 
ATOM 5232 O O   . ARG B 1 216 ? 57.044 -100.586 -9.507  1.00 80.29  ? 214 ARG B O   1 
ATOM 5233 C CB  . ARG B 1 216 ? 54.166 -101.324 -10.758 1.00 73.98  ? 214 ARG B CB  1 
ATOM 5234 C CG  . ARG B 1 216 ? 53.714 -101.712 -12.156 1.00 70.06  ? 214 ARG B CG  1 
ATOM 5235 C CD  . ARG B 1 216 ? 52.611 -100.772 -12.598 1.00 69.23  ? 214 ARG B CD  1 
ATOM 5236 N NE  . ARG B 1 216 ? 51.325 -101.023 -11.940 1.00 65.45  ? 214 ARG B NE  1 
ATOM 5237 C CZ  . ARG B 1 216 ? 50.331 -101.638 -12.563 1.00 71.40  ? 214 ARG B CZ  1 
ATOM 5238 N NH1 . ARG B 1 216 ? 50.510 -102.125 -13.783 1.00 69.87  ? 214 ARG B NH1 1 
ATOM 5239 N NH2 . ARG B 1 216 ? 49.155 -101.769 -11.971 1.00 81.19  ? 214 ARG B NH2 1 
ATOM 5240 N N   . ILE B 1 217 ? 55.551 -101.156 -7.937  1.00 73.70  ? 215 ILE B N   1 
ATOM 5241 C CA  . ILE B 1 217 ? 56.162 -100.297 -6.941  1.00 67.10  ? 215 ILE B CA  1 
ATOM 5242 C C   . ILE B 1 217 ? 57.460 -100.941 -6.474  1.00 71.06  ? 215 ILE B C   1 
ATOM 5243 O O   . ILE B 1 217 ? 58.463 -100.256 -6.313  1.00 69.45  ? 215 ILE B O   1 
ATOM 5244 C CB  . ILE B 1 217 ? 55.164 -100.035 -5.807  1.00 65.10  ? 215 ILE B CB  1 
ATOM 5245 C CG1 . ILE B 1 217 ? 53.999 -99.203  -6.340  1.00 64.43  ? 215 ILE B CG1 1 
ATOM 5246 C CG2 . ILE B 1 217 ? 55.843 -99.373  -4.614  1.00 65.54  ? 215 ILE B CG2 1 
ATOM 5247 C CD1 . ILE B 1 217 ? 52.792 -99.161  -5.431  1.00 62.95  ? 215 ILE B CD1 1 
ATOM 5248 N N   . LYS B 1 218 ? 57.444 -102.269 -6.301  1.00 79.13  ? 216 LYS B N   1 
ATOM 5249 C CA  . LYS B 1 218 ? 58.655 -103.010 -5.985  1.00 79.51  ? 216 LYS B CA  1 
ATOM 5250 C C   . LYS B 1 218 ? 59.723 -102.624 -7.001  1.00 73.63  ? 216 LYS B C   1 
ATOM 5251 O O   . LYS B 1 218 ? 60.798 -102.193 -6.612  1.00 80.95  ? 216 LYS B O   1 
ATOM 5252 C CB  . LYS B 1 218 ? 58.409 -104.528 -5.944  1.00 87.55  ? 216 LYS B CB  1 
ATOM 5253 C CG  . LYS B 1 218 ? 59.290 -105.340 -4.992  1.00 96.81  ? 216 LYS B CG  1 
ATOM 5254 C CD  . LYS B 1 218 ? 58.643 -106.594 -4.393  1.00 102.42 ? 216 LYS B CD  1 
ATOM 5255 C CE  . LYS B 1 218 ? 59.314 -107.058 -3.118  1.00 103.68 ? 216 LYS B CE  1 
ATOM 5256 N NZ  . LYS B 1 218 ? 58.445 -107.845 -2.234  1.00 99.36  ? 216 LYS B NZ  1 
ATOM 5257 N N   . GLN B 1 219 ? 59.407 -102.740 -8.295  1.00 65.66  ? 217 GLN B N   1 
ATOM 5258 C CA  . GLN B 1 219 ? 60.384 -102.482 -9.337  1.00 71.23  ? 217 GLN B CA  1 
ATOM 5259 C C   . GLN B 1 219 ? 60.891 -101.043 -9.313  1.00 71.17  ? 217 GLN B C   1 
ATOM 5260 O O   . GLN B 1 219 ? 62.035 -100.797 -9.672  1.00 62.83  ? 217 GLN B O   1 
ATOM 5261 C CB  . GLN B 1 219 ? 59.842 -102.726 -10.740 1.00 74.48  ? 217 GLN B CB  1 
ATOM 5262 C CG  . GLN B 1 219 ? 59.938 -104.174 -11.183 1.00 82.38  ? 217 GLN B CG  1 
ATOM 5263 C CD  . GLN B 1 219 ? 59.250 -104.372 -12.505 1.00 96.06  ? 217 GLN B CD  1 
ATOM 5264 O OE1 . GLN B 1 219 ? 59.872 -104.207 -13.557 1.00 124.02 ? 217 GLN B OE1 1 
ATOM 5265 N NE2 . GLN B 1 219 ? 57.952 -104.643 -12.467 1.00 102.15 ? 217 GLN B NE2 1 
ATOM 5266 N N   . SER B 1 220 ? 60.048 -100.086 -8.916  1.00 78.59  ? 218 SER B N   1 
ATOM 5267 C CA  . SER B 1 220 ? 60.419 -98.683  -9.023  1.00 79.39  ? 218 SER B CA  1 
ATOM 5268 C C   . SER B 1 220 ? 61.686 -98.402  -8.215  1.00 82.94  ? 218 SER B C   1 
ATOM 5269 O O   . SER B 1 220 ? 62.427 -97.460  -8.532  1.00 85.26  ? 218 SER B O   1 
ATOM 5270 C CB  . SER B 1 220 ? 59.273 -97.784  -8.628  1.00 76.73  ? 218 SER B CB  1 
ATOM 5271 O OG  . SER B 1 220 ? 58.758 -98.123  -7.352  1.00 75.25  ? 218 SER B OG  1 
ATOM 5272 N N   . ARG B 1 221 ? 61.921 -99.263  -7.208  1.00 79.63  ? 219 ARG B N   1 
ATOM 5273 C CA  . ARG B 1 221 ? 63.038 -99.161  -6.280  1.00 85.18  ? 219 ARG B CA  1 
ATOM 5274 C C   . ARG B 1 221 ? 64.400 -99.415  -6.929  1.00 87.95  ? 219 ARG B C   1 
ATOM 5275 O O   . ARG B 1 221 ? 65.412 -98.875  -6.485  1.00 81.67  ? 219 ARG B O   1 
ATOM 5276 C CB  . ARG B 1 221 ? 62.938 -100.253 -5.214  1.00 89.01  ? 219 ARG B CB  1 
ATOM 5277 C CG  . ARG B 1 221 ? 61.735 -100.193 -4.291  1.00 94.28  ? 219 ARG B CG  1 
ATOM 5278 C CD  . ARG B 1 221 ? 61.951 -101.148 -3.130  1.00 93.18  ? 219 ARG B CD  1 
ATOM 5279 N NE  . ARG B 1 221 ? 61.931 -102.539 -3.588  1.00 94.41  ? 219 ARG B NE  1 
ATOM 5280 C CZ  . ARG B 1 221 ? 61.896 -103.584 -2.780  1.00 112.93 ? 219 ARG B CZ  1 
ATOM 5281 N NH1 . ARG B 1 221 ? 61.921 -103.413 -1.467  1.00 116.29 ? 219 ARG B NH1 1 
ATOM 5282 N NH2 . ARG B 1 221 ? 61.816 -104.803 -3.287  1.00 118.26 ? 219 ARG B NH2 1 
ATOM 5283 N N   . GLY B 1 222 ? 64.438 -100.308 -7.923  1.00 87.60  ? 220 GLY B N   1 
ATOM 5284 C CA  . GLY B 1 222 ? 65.692 -100.759 -8.501  1.00 80.40  ? 220 GLY B CA  1 
ATOM 5285 C C   . GLY B 1 222 ? 66.647 -99.597  -8.743  1.00 81.46  ? 220 GLY B C   1 
ATOM 5286 O O   . GLY B 1 222 ? 67.793 -99.639  -8.309  1.00 84.58  ? 220 GLY B O   1 
ATOM 5287 N N   . HIS B 1 223 ? 66.149 -98.554  -9.415  1.00 89.39  ? 221 HIS B N   1 
ATOM 5288 C CA  . HIS B 1 223 ? 66.982 -97.443  -9.850  1.00 91.59  ? 221 HIS B CA  1 
ATOM 5289 C C   . HIS B 1 223 ? 67.484 -96.634  -8.650  1.00 77.93  ? 221 HIS B C   1 
ATOM 5290 O O   . HIS B 1 223 ? 68.502 -95.966  -8.766  1.00 75.75  ? 221 HIS B O   1 
ATOM 5291 C CB  . HIS B 1 223 ? 66.249 -96.624  -10.927 1.00 95.33  ? 221 HIS B CB  1 
ATOM 5292 C CG  . HIS B 1 223 ? 66.199 -97.286  -12.275 1.00 84.81  ? 221 HIS B CG  1 
ATOM 5293 N ND1 . HIS B 1 223 ? 67.279 -97.954  -12.811 1.00 79.82  ? 221 HIS B ND1 1 
ATOM 5294 C CD2 . HIS B 1 223 ? 65.230 -97.369  -13.199 1.00 76.23  ? 221 HIS B CD2 1 
ATOM 5295 C CE1 . HIS B 1 223 ? 66.960 -98.427  -14.012 1.00 81.10  ? 221 HIS B CE1 1 
ATOM 5296 N NE2 . HIS B 1 223 ? 65.713 -98.088  -14.262 1.00 80.98  ? 221 HIS B NE2 1 
ATOM 5297 N N   . LEU B 1 224 ? 66.792 -96.720  -7.501  1.00 72.76  ? 222 LEU B N   1 
ATOM 5298 C CA  . LEU B 1 224 ? 67.137 -95.956  -6.307  1.00 70.47  ? 222 LEU B CA  1 
ATOM 5299 C C   . LEU B 1 224 ? 68.384 -96.505  -5.612  1.00 72.99  ? 222 LEU B C   1 
ATOM 5300 O O   . LEU B 1 224 ? 69.048 -95.761  -4.887  1.00 61.00  ? 222 LEU B O   1 
ATOM 5301 C CB  . LEU B 1 224 ? 65.966 -95.960  -5.324  1.00 68.92  ? 222 LEU B CB  1 
ATOM 5302 C CG  . LEU B 1 224 ? 64.717 -95.182  -5.737  1.00 65.45  ? 222 LEU B CG  1 
ATOM 5303 C CD1 . LEU B 1 224 ? 63.571 -95.459  -4.799  1.00 61.46  ? 222 LEU B CD1 1 
ATOM 5304 C CD2 . LEU B 1 224 ? 65.035 -93.709  -5.755  1.00 67.31  ? 222 LEU B CD2 1 
ATOM 5305 N N   . TYR B 1 225 ? 68.654 -97.811  -5.792  1.00 77.25  ? 223 TYR B N   1 
ATOM 5306 C CA  . TYR B 1 225 ? 69.767 -98.493  -5.142  1.00 69.05  ? 223 TYR B CA  1 
ATOM 5307 C C   . TYR B 1 225 ? 71.095 -97.905  -5.612  1.00 68.14  ? 223 TYR B C   1 
ATOM 5308 O O   . TYR B 1 225 ? 72.071 -97.918  -4.881  1.00 67.75  ? 223 TYR B O   1 
ATOM 5309 C CB  . TYR B 1 225 ? 69.709 -100.002 -5.406  1.00 69.84  ? 223 TYR B CB  1 
ATOM 5310 C CG  . TYR B 1 225 ? 68.569 -100.726 -4.697  1.00 73.70  ? 223 TYR B CG  1 
ATOM 5311 C CD1 . TYR B 1 225 ? 68.399 -100.608 -3.323  1.00 78.25  ? 223 TYR B CD1 1 
ATOM 5312 C CD2 . TYR B 1 225 ? 67.653 -101.509 -5.389  1.00 72.38  ? 223 TYR B CD2 1 
ATOM 5313 C CE1 . TYR B 1 225 ? 67.369 -101.253 -2.658  1.00 76.24  ? 223 TYR B CE1 1 
ATOM 5314 C CE2 . TYR B 1 225 ? 66.610 -102.151 -4.738  1.00 73.73  ? 223 TYR B CE2 1 
ATOM 5315 C CZ  . TYR B 1 225 ? 66.471 -102.023 -3.367  1.00 76.30  ? 223 TYR B CZ  1 
ATOM 5316 O OH  . TYR B 1 225 ? 65.460 -102.604 -2.662  1.00 85.93  ? 223 TYR B OH  1 
ATOM 5317 N N   . GLU B 1 226 ? 71.119 -97.380  -6.838  1.00 79.54  ? 224 GLU B N   1 
ATOM 5318 C CA  . GLU B 1 226 ? 72.273 -96.663  -7.359  1.00 84.48  ? 224 GLU B CA  1 
ATOM 5319 C C   . GLU B 1 226 ? 72.323 -95.268  -6.736  1.00 76.98  ? 224 GLU B C   1 
ATOM 5320 O O   . GLU B 1 226 ? 71.328 -94.555  -6.753  1.00 81.98  ? 224 GLU B O   1 
ATOM 5321 C CB  . GLU B 1 226 ? 72.182 -96.599  -8.882  1.00 91.36  ? 224 GLU B CB  1 
ATOM 5322 C CG  . GLU B 1 226 ? 71.865 -97.947  -9.521  1.00 91.04  ? 224 GLU B CG  1 
ATOM 5323 C CD  . GLU B 1 226 ? 71.737 -97.780  -11.013 1.00 102.14 ? 224 GLU B CD  1 
ATOM 5324 O OE1 . GLU B 1 226 ? 72.354 -96.840  -11.562 1.00 105.35 ? 224 GLU B OE1 1 
ATOM 5325 O OE2 . GLU B 1 226 ? 70.978 -98.566  -11.602 1.00 107.07 ? 224 GLU B OE2 1 
ATOM 5326 N N   . ILE B 1 227 ? 73.480 -94.886  -6.187  1.00 72.15  ? 225 ILE B N   1 
ATOM 5327 C CA  . ILE B 1 227 ? 73.628 -93.620  -5.481  1.00 78.02  ? 225 ILE B CA  1 
ATOM 5328 C C   . ILE B 1 227 ? 74.851 -92.877  -6.014  1.00 77.13  ? 225 ILE B C   1 
ATOM 5329 O O   . ILE B 1 227 ? 75.825 -93.503  -6.420  1.00 87.11  ? 225 ILE B O   1 
ATOM 5330 C CB  . ILE B 1 227 ? 73.712 -93.854  -3.960  1.00 87.71  ? 225 ILE B CB  1 
ATOM 5331 C CG1 . ILE B 1 227 ? 74.769 -94.901  -3.589  1.00 87.56  ? 225 ILE B CG1 1 
ATOM 5332 C CG2 . ILE B 1 227 ? 72.346 -94.243  -3.397  1.00 97.97  ? 225 ILE B CG2 1 
ATOM 5333 C CD1 . ILE B 1 227 ? 75.132 -94.923  -2.116  1.00 84.21  ? 225 ILE B CD1 1 
ATOM 5334 N N   . ASN B 1 228 ? 74.816 -91.542  -5.946  1.00 78.34  ? 226 ASN B N   1 
ATOM 5335 C CA  . ASN B 1 228 ? 75.775 -90.709  -6.658  1.00 82.40  ? 226 ASN B CA  1 
ATOM 5336 C C   . ASN B 1 228 ? 76.876 -90.216  -5.724  1.00 84.66  ? 226 ASN B C   1 
ATOM 5337 O O   . ASN B 1 228 ? 77.513 -89.201  -5.998  1.00 79.93  ? 226 ASN B O   1 
ATOM 5338 C CB  . ASN B 1 228 ? 75.088 -89.502  -7.291  1.00 85.25  ? 226 ASN B CB  1 
ATOM 5339 C CG  . ASN B 1 228 ? 74.797 -88.401  -6.296  1.00 78.19  ? 226 ASN B CG  1 
ATOM 5340 O OD1 . ASN B 1 228 ? 74.356 -88.674  -5.177  1.00 80.17  ? 226 ASN B OD1 1 
ATOM 5341 N ND2 . ASN B 1 228 ? 75.055 -87.156  -6.671  1.00 79.68  ? 226 ASN B ND2 1 
ATOM 5342 N N   . MET B 1 229 ? 77.090 -90.937  -4.621  1.00 94.28  ? 227 MET B N   1 
ATOM 5343 C CA  . MET B 1 229 ? 77.930 -90.440  -3.543  1.00 95.27  ? 227 MET B CA  1 
ATOM 5344 C C   . MET B 1 229 ? 79.369 -90.278  -4.050  1.00 100.08 ? 227 MET B C   1 
ATOM 5345 O O   . MET B 1 229 ? 79.950 -91.194  -4.639  1.00 82.49  ? 227 MET B O   1 
ATOM 5346 C CB  . MET B 1 229 ? 77.852 -91.383  -2.335  1.00 89.85  ? 227 MET B CB  1 
ATOM 5347 C CG  . MET B 1 229 ? 78.237 -90.749  -1.016  1.00 89.94  ? 227 MET B CG  1 
ATOM 5348 S SD  . MET B 1 229 ? 77.025 -89.532  -0.465  1.00 89.50  ? 227 MET B SD  1 
ATOM 5349 C CE  . MET B 1 229 ? 78.101 -88.526  0.570   1.00 96.63  ? 227 MET B CE  1 
ATOM 5350 N N   . GLY B 1 230 ? 79.935 -89.084  -3.831  1.00 105.68 ? 228 GLY B N   1 
ATOM 5351 C CA  . GLY B 1 230 ? 81.271 -88.762  -4.302  1.00 95.63  ? 228 GLY B CA  1 
ATOM 5352 C C   . GLY B 1 230 ? 81.228 -88.103  -5.675  1.00 90.37  ? 228 GLY B C   1 
ATOM 5353 O O   . GLY B 1 230 ? 82.250 -88.001  -6.342  1.00 96.28  ? 228 GLY B O   1 
ATOM 5354 N N   . ALA B 1 231 ? 80.037 -87.660  -6.083  1.00 87.86  ? 229 ALA B N   1 
ATOM 5355 C CA  . ALA B 1 231 ? 79.878 -86.895  -7.304  1.00 94.10  ? 229 ALA B CA  1 
ATOM 5356 C C   . ALA B 1 231 ? 80.346 -85.466  -7.067  1.00 95.65  ? 229 ALA B C   1 
ATOM 5357 O O   . ALA B 1 231 ? 80.774 -84.788  -7.998  1.00 91.80  ? 229 ALA B O   1 
ATOM 5358 C CB  . ALA B 1 231 ? 78.433 -86.922  -7.733  1.00 104.42 ? 229 ALA B CB  1 
ATOM 5359 N N   . THR B 1 232 ? 80.237 -85.022  -5.812  1.00 92.25  ? 230 THR B N   1 
ATOM 5360 C CA  . THR B 1 232 ? 80.579 -83.663  -5.435  1.00 91.30  ? 230 THR B CA  1 
ATOM 5361 C C   . THR B 1 232 ? 79.686 -82.698  -6.222  1.00 102.32 ? 230 THR B C   1 
ATOM 5362 O O   . THR B 1 232 ? 78.472 -82.906  -6.245  1.00 103.83 ? 230 THR B O   1 
ATOM 5363 C CB  . THR B 1 232 ? 82.085 -83.469  -5.626  1.00 88.61  ? 230 THR B CB  1 
ATOM 5364 O OG1 . THR B 1 232 ? 82.354 -83.202  -7.004  1.00 83.81  ? 230 THR B OG1 1 
ATOM 5365 C CG2 . THR B 1 232 ? 82.857 -84.669  -5.092  1.00 85.79  ? 230 THR B CG2 1 
ATOM 5366 N N   . ALA B 1 233 ? 80.278 -81.677  -6.871  1.00 103.83 ? 231 ALA B N   1 
ATOM 5367 C CA  . ALA B 1 233 ? 79.519 -80.573  -7.452  1.00 97.71  ? 231 ALA B CA  1 
ATOM 5368 C C   . ALA B 1 233 ? 78.606 -81.045  -8.587  1.00 102.91 ? 231 ALA B C   1 
ATOM 5369 O O   . ALA B 1 233 ? 77.400 -80.806  -8.545  1.00 108.46 ? 231 ALA B O   1 
ATOM 5370 C CB  . ALA B 1 233 ? 80.453 -79.482  -7.932  1.00 88.15  ? 231 ALA B CB  1 
ATOM 5371 N N   . VAL B 1 234 ? 79.183 -81.735  -9.581  1.00 101.18 ? 232 VAL B N   1 
ATOM 5372 C CA  . VAL B 1 234 ? 78.592 -81.831  -10.912 1.00 89.92  ? 232 VAL B CA  1 
ATOM 5373 C C   . VAL B 1 234 ? 78.462 -83.270  -11.424 1.00 89.24  ? 232 VAL B C   1 
ATOM 5374 O O   . VAL B 1 234 ? 77.649 -83.541  -12.312 1.00 87.90  ? 232 VAL B O   1 
ATOM 5375 C CB  . VAL B 1 234 ? 79.516 -80.953  -11.776 1.00 79.67  ? 232 VAL B CB  1 
ATOM 5376 C CG1 . VAL B 1 234 ? 79.592 -81.402  -13.226 1.00 76.64  ? 232 VAL B CG1 1 
ATOM 5377 C CG2 . VAL B 1 234 ? 79.108 -79.494  -11.663 1.00 76.59  ? 232 VAL B CG2 1 
ATOM 5378 N N   . GLY B 1 235 ? 79.250 -84.183  -10.845 1.00 91.79  ? 233 GLY B N   1 
ATOM 5379 C CA  . GLY B 1 235 ? 79.341 -85.561  -11.299 1.00 93.06  ? 233 GLY B CA  1 
ATOM 5380 C C   . GLY B 1 235 ? 80.793 -85.954  -11.583 1.00 95.17  ? 233 GLY B C   1 
ATOM 5381 O O   . GLY B 1 235 ? 81.118 -87.143  -11.585 1.00 85.41  ? 233 GLY B O   1 
ATOM 5382 N N   . THR B 1 236 ? 81.636 -84.930  -11.822 1.00 92.06  ? 234 THR B N   1 
ATOM 5383 C CA  . THR B 1 236 ? 83.050 -85.071  -12.129 1.00 88.00  ? 234 THR B CA  1 
ATOM 5384 C C   . THR B 1 236 ? 83.789 -85.735  -10.972 1.00 98.71  ? 234 THR B C   1 
ATOM 5385 O O   . THR B 1 236 ? 84.829 -86.345  -11.187 1.00 123.76 ? 234 THR B O   1 
ATOM 5386 C CB  . THR B 1 236 ? 83.676 -83.712  -12.467 1.00 90.32  ? 234 THR B CB  1 
ATOM 5387 O OG1 . THR B 1 236 ? 83.529 -82.758  -11.416 1.00 87.31  ? 234 THR B OG1 1 
ATOM 5388 C CG2 . THR B 1 236 ? 83.078 -83.111  -13.723 1.00 92.94  ? 234 THR B CG2 1 
ATOM 5389 N N   . GLY B 1 237 ? 83.277 -85.596  -9.749  1.00 104.54 ? 235 GLY B N   1 
ATOM 5390 C CA  . GLY B 1 237 ? 83.854 -86.262  -8.591  1.00 102.21 ? 235 GLY B CA  1 
ATOM 5391 C C   . GLY B 1 237 ? 85.147 -85.586  -8.141  1.00 103.04 ? 235 GLY B C   1 
ATOM 5392 O O   . GLY B 1 237 ? 86.029 -86.213  -7.554  1.00 126.12 ? 235 GLY B O   1 
ATOM 5393 N N   . LEU B 1 238 ? 85.227 -84.278  -8.421  1.00 92.32  ? 236 LEU B N   1 
ATOM 5394 C CA  . LEU B 1 238 ? 86.318 -83.419  -7.999  1.00 82.56  ? 236 LEU B CA  1 
ATOM 5395 C C   . LEU B 1 238 ? 86.298 -83.282  -6.480  1.00 85.65  ? 236 LEU B C   1 
ATOM 5396 O O   . LEU B 1 238 ? 85.235 -83.069  -5.907  1.00 90.92  ? 236 LEU B O   1 
ATOM 5397 C CB  . LEU B 1 238 ? 86.095 -82.070  -8.676  1.00 81.59  ? 236 LEU B CB  1 
ATOM 5398 C CG  . LEU B 1 238 ? 87.089 -80.956  -8.342  1.00 82.83  ? 236 LEU B CG  1 
ATOM 5399 C CD1 . LEU B 1 238 ? 88.404 -81.268  -9.013  1.00 83.86  ? 236 LEU B CD1 1 
ATOM 5400 C CD2 . LEU B 1 238 ? 86.537 -79.584  -8.723  1.00 83.25  ? 236 LEU B CD2 1 
ATOM 5401 N N   . ASN B 1 239 ? 87.482 -83.404  -5.862  1.00 90.07  ? 237 ASN B N   1 
ATOM 5402 C CA  . ASN B 1 239 ? 87.712 -83.217  -4.431  1.00 85.44  ? 237 ASN B CA  1 
ATOM 5403 C C   . ASN B 1 239 ? 87.338 -84.474  -3.651  1.00 90.72  ? 237 ASN B C   1 
ATOM 5404 O O   . ASN B 1 239 ? 87.337 -84.445  -2.425  1.00 92.10  ? 237 ASN B O   1 
ATOM 5405 C CB  . ASN B 1 239 ? 87.027 -81.977  -3.857  1.00 82.94  ? 237 ASN B CB  1 
ATOM 5406 C CG  . ASN B 1 239 ? 87.620 -80.677  -4.360  1.00 86.49  ? 237 ASN B CG  1 
ATOM 5407 O OD1 . ASN B 1 239 ? 88.746 -80.633  -4.880  1.00 75.59  ? 237 ASN B OD1 1 
ATOM 5408 N ND2 . ASN B 1 239 ? 86.888 -79.588  -4.165  1.00 86.46  ? 237 ASN B ND2 1 
ATOM 5409 N N   . ALA B 1 240 ? 87.034 -85.571  -4.357  1.00 109.69 ? 238 ALA B N   1 
ATOM 5410 C CA  . ALA B 1 240 ? 86.714 -86.834  -3.715  1.00 118.31 ? 238 ALA B CA  1 
ATOM 5411 C C   . ALA B 1 240 ? 87.764 -87.857  -4.127  1.00 129.72 ? 238 ALA B C   1 
ATOM 5412 O O   . ALA B 1 240 ? 88.073 -87.994  -5.309  1.00 149.03 ? 238 ALA B O   1 
ATOM 5413 C CB  . ALA B 1 240 ? 85.318 -87.287  -4.089  1.00 114.24 ? 238 ALA B CB  1 
ATOM 5414 N N   . ASP B 1 241 ? 88.309 -88.569  -3.136  1.00 122.86 ? 239 ASP B N   1 
ATOM 5415 C CA  . ASP B 1 241 ? 89.324 -89.581  -3.379  1.00 104.77 ? 239 ASP B CA  1 
ATOM 5416 C C   . ASP B 1 241 ? 88.631 -90.901  -3.699  1.00 91.18  ? 239 ASP B C   1 
ATOM 5417 O O   . ASP B 1 241 ? 87.771 -91.325  -2.941  1.00 88.54  ? 239 ASP B O   1 
ATOM 5418 C CB  . ASP B 1 241 ? 90.235 -89.698  -2.173  1.00 105.17 ? 239 ASP B CB  1 
ATOM 5419 C CG  . ASP B 1 241 ? 91.234 -90.839  -2.214  1.00 107.27 ? 239 ASP B CG  1 
ATOM 5420 O OD1 . ASP B 1 241 ? 91.374 -91.477  -3.277  1.00 108.20 ? 239 ASP B OD1 1 
ATOM 5421 O OD2 . ASP B 1 241 ? 91.852 -91.092  -1.168  1.00 114.37 ? 239 ASP B OD2 1 
ATOM 5422 N N   . PRO B 1 242 ? 88.967 -91.606  -4.807  1.00 88.39  ? 240 PRO B N   1 
ATOM 5423 C CA  . PRO B 1 242 ? 88.287 -92.862  -5.143  1.00 93.15  ? 240 PRO B CA  1 
ATOM 5424 C C   . PRO B 1 242 ? 88.214 -93.842  -3.970  1.00 100.29 ? 240 PRO B C   1 
ATOM 5425 O O   . PRO B 1 242 ? 87.275 -94.633  -3.885  1.00 91.08  ? 240 PRO B O   1 
ATOM 5426 C CB  . PRO B 1 242 ? 89.078 -93.420  -6.336  1.00 83.92  ? 240 PRO B CB  1 
ATOM 5427 C CG  . PRO B 1 242 ? 89.717 -92.193  -6.957  1.00 78.49  ? 240 PRO B CG  1 
ATOM 5428 C CD  . PRO B 1 242 ? 89.986 -91.236  -5.800  1.00 80.96  ? 240 PRO B CD  1 
ATOM 5429 N N   . ARG B 1 243 ? 89.197 -93.759  -3.063  1.00 107.21 ? 241 ARG B N   1 
ATOM 5430 C CA  . ARG B 1 243 ? 89.230 -94.590  -1.867  1.00 107.36 ? 241 ARG B CA  1 
ATOM 5431 C C   . ARG B 1 243 ? 88.080 -94.222  -0.927  1.00 103.59 ? 241 ARG B C   1 
ATOM 5432 O O   . ARG B 1 243 ? 87.463 -95.111  -0.338  1.00 103.85 ? 241 ARG B O   1 
ATOM 5433 C CB  . ARG B 1 243 ? 90.581 -94.438  -1.159  1.00 110.94 ? 241 ARG B CB  1 
ATOM 5434 C CG  . ARG B 1 243 ? 91.772 -94.794  -2.030  1.00 118.83 ? 241 ARG B CG  1 
ATOM 5435 C CD  . ARG B 1 243 ? 93.086 -94.721  -1.271  1.00 127.23 ? 241 ARG B CD  1 
ATOM 5436 N NE  . ARG B 1 243 ? 94.145 -95.235  -2.147  1.00 142.78 ? 241 ARG B NE  1 
ATOM 5437 C CZ  . ARG B 1 243 ? 94.136 -96.438  -2.729  1.00 141.40 ? 241 ARG B CZ  1 
ATOM 5438 N NH1 . ARG B 1 243 ? 93.207 -97.324  -2.416  1.00 145.51 ? 241 ARG B NH1 1 
ATOM 5439 N NH2 . ARG B 1 243 ? 95.064 -96.768  -3.609  1.00 133.67 ? 241 ARG B NH2 1 
ATOM 5440 N N   . TYR B 1 244 ? 87.821 -92.910  -0.791  1.00 95.75  ? 242 TYR B N   1 
ATOM 5441 C CA  . TYR B 1 244 ? 86.691 -92.383  -0.033  1.00 90.52  ? 242 TYR B CA  1 
ATOM 5442 C C   . TYR B 1 244 ? 85.385 -92.830  -0.686  1.00 92.44  ? 242 TYR B C   1 
ATOM 5443 O O   . TYR B 1 244 ? 84.436 -93.198  0.006   1.00 90.81  ? 242 TYR B O   1 
ATOM 5444 C CB  . TYR B 1 244 ? 86.724 -90.851  0.078   1.00 87.38  ? 242 TYR B CB  1 
ATOM 5445 C CG  . TYR B 1 244 ? 85.361 -90.195  0.261   1.00 96.34  ? 242 TYR B CG  1 
ATOM 5446 C CD1 . TYR B 1 244 ? 84.603 -89.811  -0.838  1.00 100.01 ? 242 TYR B CD1 1 
ATOM 5447 C CD2 . TYR B 1 244 ? 84.823 -89.958  1.524   1.00 108.74 ? 242 TYR B CD2 1 
ATOM 5448 C CE1 . TYR B 1 244 ? 83.351 -89.229  -0.691  1.00 113.96 ? 242 TYR B CE1 1 
ATOM 5449 C CE2 . TYR B 1 244 ? 83.578 -89.364  1.685   1.00 115.49 ? 242 TYR B CE2 1 
ATOM 5450 C CZ  . TYR B 1 244 ? 82.829 -89.003  0.572   1.00 115.71 ? 242 TYR B CZ  1 
ATOM 5451 O OH  . TYR B 1 244 ? 81.590 -88.416  0.665   1.00 100.40 ? 242 TYR B OH  1 
ATOM 5452 N N   . ILE B 1 245 ? 85.349 -92.781  -2.021  1.00 86.25  ? 243 ILE B N   1 
ATOM 5453 C CA  . ILE B 1 245 ? 84.164 -93.140  -2.779  1.00 83.58  ? 243 ILE B CA  1 
ATOM 5454 C C   . ILE B 1 245 ? 83.847 -94.613  -2.553  1.00 84.69  ? 243 ILE B C   1 
ATOM 5455 O O   . ILE B 1 245 ? 82.699 -94.953  -2.297  1.00 85.20  ? 243 ILE B O   1 
ATOM 5456 C CB  . ILE B 1 245 ? 84.340 -92.794  -4.269  1.00 79.10  ? 243 ILE B CB  1 
ATOM 5457 C CG1 . ILE B 1 245 ? 84.412 -91.261  -4.450  1.00 85.57  ? 243 ILE B CG1 1 
ATOM 5458 C CG2 . ILE B 1 245 ? 83.256 -93.447  -5.133  1.00 68.21  ? 243 ILE B CG2 1 
ATOM 5459 C CD1 . ILE B 1 245 ? 84.761 -90.785  -5.850  1.00 86.91  ? 243 ILE B CD1 1 
ATOM 5460 N N   . GLU B 1 246 ? 84.866 -95.473  -2.642  1.00 90.40  ? 244 GLU B N   1 
ATOM 5461 C CA  . GLU B 1 246 ? 84.676 -96.902  -2.438  1.00 94.05  ? 244 GLU B CA  1 
ATOM 5462 C C   . GLU B 1 246 ? 84.225 -97.180  -1.005  1.00 88.42  ? 244 GLU B C   1 
ATOM 5463 O O   . GLU B 1 246 ? 83.337 -98.002  -0.794  1.00 92.94  ? 244 GLU B O   1 
ATOM 5464 C CB  . GLU B 1 246 ? 85.948 -97.654  -2.823  1.00 104.81 ? 244 GLU B CB  1 
ATOM 5465 C CG  . GLU B 1 246 ? 86.164 -97.626  -4.335  1.00 118.72 ? 244 GLU B CG  1 
ATOM 5466 C CD  . GLU B 1 246 ? 87.245 -98.535  -4.888  1.00 133.06 ? 244 GLU B CD  1 
ATOM 5467 O OE1 . GLU B 1 246 ? 88.448 -98.290  -4.661  1.00 151.58 ? 244 GLU B OE1 1 
ATOM 5468 O OE2 . GLU B 1 246 ? 86.858 -99.509  -5.561  1.00 132.45 ? 244 GLU B OE2 1 
ATOM 5469 N N   . SER B 1 247 ? 84.820 -96.450  -0.050  1.00 88.85  ? 245 SER B N   1 
ATOM 5470 C CA  . SER B 1 247 ? 84.548 -96.657  1.365   1.00 93.26  ? 245 SER B CA  1 
ATOM 5471 C C   . SER B 1 247 ? 83.138 -96.192  1.723   1.00 99.35  ? 245 SER B C   1 
ATOM 5472 O O   . SER B 1 247 ? 82.357 -96.952  2.301   1.00 94.47  ? 245 SER B O   1 
ATOM 5473 C CB  . SER B 1 247 ? 85.562 -95.955  2.239   1.00 86.74  ? 245 SER B CB  1 
ATOM 5474 O OG  . SER B 1 247 ? 85.208 -96.066  3.610   1.00 77.30  ? 245 SER B OG  1 
ATOM 5475 N N   . VAL B 1 248 ? 82.845 -94.926  1.392   1.00 94.93  ? 246 VAL B N   1 
ATOM 5476 C CA  . VAL B 1 248 ? 81.636 -94.260  1.854   1.00 86.05  ? 246 VAL B CA  1 
ATOM 5477 C C   . VAL B 1 248 ? 80.411 -95.045  1.387   1.00 82.69  ? 246 VAL B C   1 
ATOM 5478 O O   . VAL B 1 248 ? 79.417 -95.107  2.100   1.00 78.82  ? 246 VAL B O   1 
ATOM 5479 C CB  . VAL B 1 248 ? 81.577 -92.786  1.406   1.00 77.66  ? 246 VAL B CB  1 
ATOM 5480 C CG1 . VAL B 1 248 ? 81.349 -92.653  -0.092  1.00 77.17  ? 246 VAL B CG1 1 
ATOM 5481 C CG2 . VAL B 1 248 ? 80.523 -92.003  2.185   1.00 78.09  ? 246 VAL B CG2 1 
ATOM 5482 N N   . VAL B 1 249 ? 80.531 -95.721  0.250   1.00 89.40  ? 247 VAL B N   1 
ATOM 5483 C CA  . VAL B 1 249 ? 79.397 -96.549  -0.243  1.00 93.06  ? 247 VAL B CA  1 
ATOM 5484 C C   . VAL B 1 249 ? 79.255 -97.752  0.695   1.00 95.06  ? 247 VAL B C   1 
ATOM 5485 O O   . VAL B 1 249 ? 78.183 -97.911  1.301   1.00 93.77  ? 247 VAL B O   1 
ATOM 5486 C CB  . VAL B 1 249 ? 79.599 -96.993  -1.702  1.00 30.00  ? 247 VAL B CB  1 
ATOM 5487 C CG1 . VAL B 1 249 ? 78.621 -98.088  -2.105  1.00 30.00  ? 247 VAL B CG1 1 
ATOM 5488 C CG2 . VAL B 1 249 ? 79.496 -95.815  -2.660  1.00 30.00  ? 247 VAL B CG2 1 
ATOM 5489 N N   . LYS B 1 250 ? 80.304 -98.559  0.804   1.00 102.87 ? 248 LYS B N   1 
ATOM 5490 C CA  . LYS B 1 250 ? 80.213 -99.778  1.638   1.00 105.39 ? 248 LYS B CA  1 
ATOM 5491 C C   . LYS B 1 250 ? 79.656 -99.384  3.008   1.00 97.00  ? 248 LYS B C   1 
ATOM 5492 O O   . LYS B 1 250 ? 78.795 -100.112 3.531   1.00 95.53  ? 248 LYS B O   1 
ATOM 5493 C CB  . LYS B 1 250 ? 81.585 -100.432 1.800   1.00 116.89 ? 248 LYS B CB  1 
ATOM 5494 C CG  . LYS B 1 250 ? 82.161 -101.028 0.526   1.00 128.02 ? 248 LYS B CG  1 
ATOM 5495 C CD  . LYS B 1 250 ? 83.676 -101.185 0.579   1.00 126.02 ? 248 LYS B CD  1 
ATOM 5496 C CE  . LYS B 1 250 ? 84.249 -101.661 -0.716  1.00 117.75 ? 248 LYS B CE  1 
ATOM 5497 N NZ  . LYS B 1 250 ? 84.489 -103.106 -0.698  1.00 116.15 ? 248 LYS B NZ  1 
ATOM 5498 N N   . HIS B 1 251 ? 80.124 -98.269  3.559   1.00 90.27  ? 249 HIS B N   1 
ATOM 5499 C CA  . HIS B 1 251 ? 79.558 -97.898  4.850   1.00 91.60  ? 249 HIS B CA  1 
ATOM 5500 C C   . HIS B 1 251 ? 78.054 -97.656  4.754   1.00 93.13  ? 249 HIS B C   1 
ATOM 5501 O O   . HIS B 1 251 ? 77.292 -98.130  5.594   1.00 93.13  ? 249 HIS B O   1 
ATOM 5502 C CB  . HIS B 1 251 ? 80.263 -96.668  5.424   1.00 90.29  ? 249 HIS B CB  1 
ATOM 5503 C CG  . HIS B 1 251 ? 81.544 -97.007  6.106   1.00 102.90 ? 249 HIS B CG  1 
ATOM 5504 N ND1 . HIS B 1 251 ? 81.679 -98.071  6.976   1.00 103.67 ? 249 HIS B ND1 1 
ATOM 5505 C CD2 . HIS B 1 251 ? 82.738 -96.414  6.056   1.00 104.29 ? 249 HIS B CD2 1 
ATOM 5506 C CE1 . HIS B 1 251 ? 82.926 -98.116  7.419   1.00 100.92 ? 249 HIS B CE1 1 
ATOM 5507 N NE2 . HIS B 1 251 ? 83.587 -97.116  6.877   1.00 106.16 ? 249 HIS B NE2 1 
ATOM 5508 N N   . LEU B 1 252 ? 77.634 -96.902  3.735   1.00 96.15  ? 250 LEU B N   1 
ATOM 5509 C CA  . LEU B 1 252 ? 76.229 -96.565  3.568   1.00 91.00  ? 250 LEU B CA  1 
ATOM 5510 C C   . LEU B 1 252 ? 75.417 -97.847  3.446   1.00 84.31  ? 250 LEU B C   1 
ATOM 5511 O O   . LEU B 1 252 ? 74.299 -97.904  3.959   1.00 71.63  ? 250 LEU B O   1 
ATOM 5512 C CB  . LEU B 1 252 ? 76.003 -95.657  2.360   1.00 102.54 ? 250 LEU B CB  1 
ATOM 5513 C CG  . LEU B 1 252 ? 76.275 -94.163  2.573   1.00 111.82 ? 250 LEU B CG  1 
ATOM 5514 C CD1 . LEU B 1 252 ? 76.272 -93.390  1.255   1.00 112.48 ? 250 LEU B CD1 1 
ATOM 5515 C CD2 . LEU B 1 252 ? 75.255 -93.573  3.538   1.00 120.03 ? 250 LEU B CD2 1 
ATOM 5516 N N   . ARG B 1 253 ? 75.998 -98.851  2.766   1.00 87.24  ? 251 ARG B N   1 
ATOM 5517 C CA  . ARG B 1 253 ? 75.343 -100.136 2.577   1.00 99.16  ? 251 ARG B CA  1 
ATOM 5518 C C   . ARG B 1 253 ? 75.138 -100.823 3.928   1.00 101.59 ? 251 ARG B C   1 
ATOM 5519 O O   . ARG B 1 253 ? 74.078 -101.405 4.177   1.00 100.11 ? 251 ARG B O   1 
ATOM 5520 C CB  . ARG B 1 253 ? 76.103 -101.091 1.642   1.00 103.46 ? 251 ARG B CB  1 
ATOM 5521 C CG  . ARG B 1 253 ? 75.167 -102.156 1.079   1.00 115.98 ? 251 ARG B CG  1 
ATOM 5522 C CD  . ARG B 1 253 ? 75.750 -103.526 0.735   1.00 120.41 ? 251 ARG B CD  1 
ATOM 5523 N NE  . ARG B 1 253 ? 76.627 -103.510 -0.440  1.00 109.28 ? 251 ARG B NE  1 
ATOM 5524 C CZ  . ARG B 1 253 ? 77.871 -103.972 -0.426  1.00 123.92 ? 251 ARG B CZ  1 
ATOM 5525 N NH1 . ARG B 1 253 ? 78.419 -104.380 0.710   1.00 123.49 ? 251 ARG B NH1 1 
ATOM 5526 N NH2 . ARG B 1 253 ? 78.570 -104.017 -1.546  1.00 133.80 ? 251 ARG B NH2 1 
ATOM 5527 N N   . GLU B 1 254 ? 76.173 -100.782 4.781   1.00 101.58 ? 252 GLU B N   1 
ATOM 5528 C CA  . GLU B 1 254 ? 76.112 -101.404 6.093   1.00 99.20  ? 252 GLU B CA  1 
ATOM 5529 C C   . GLU B 1 254 ? 75.147 -100.621 6.974   1.00 88.15  ? 252 GLU B C   1 
ATOM 5530 O O   . GLU B 1 254 ? 74.227 -101.204 7.542   1.00 90.41  ? 252 GLU B O   1 
ATOM 5531 C CB  . GLU B 1 254 ? 77.464 -101.449 6.806   1.00 105.15 ? 252 GLU B CB  1 
ATOM 5532 C CG  . GLU B 1 254 ? 78.468 -102.404 6.171   1.00 111.45 ? 252 GLU B CG  1 
ATOM 5533 C CD  . GLU B 1 254 ? 79.878 -102.119 6.661   1.00 119.61 ? 252 GLU B CD  1 
ATOM 5534 O OE1 . GLU B 1 254 ? 80.009 -101.752 7.849   1.00 127.40 ? 252 GLU B OE1 1 
ATOM 5535 O OE2 . GLU B 1 254 ? 80.842 -102.260 5.880   1.00 122.93 ? 252 GLU B OE2 1 
ATOM 5536 N N   . ILE B 1 255 ? 75.373 -99.304  7.072   1.00 74.87  ? 253 ILE B N   1 
ATOM 5537 C CA  . ILE B 1 255 ? 74.567 -98.442  7.918   1.00 69.63  ? 253 ILE B CA  1 
ATOM 5538 C C   . ILE B 1 255 ? 73.094 -98.614  7.578   1.00 75.80  ? 253 ILE B C   1 
ATOM 5539 O O   . ILE B 1 255 ? 72.297 -98.902  8.466   1.00 79.16  ? 253 ILE B O   1 
ATOM 5540 C CB  . ILE B 1 255 ? 74.990 -96.975  7.770   1.00 70.57  ? 253 ILE B CB  1 
ATOM 5541 C CG1 . ILE B 1 255 ? 76.371 -96.756  8.368   1.00 77.34  ? 253 ILE B CG1 1 
ATOM 5542 C CG2 . ILE B 1 255 ? 73.942 -96.046  8.390   1.00 69.45  ? 253 ILE B CG2 1 
ATOM 5543 C CD1 . ILE B 1 255 ? 76.903 -95.346  8.225   1.00 76.03  ? 253 ILE B CD1 1 
ATOM 5544 N N   . SER B 1 256 ? 72.754 -98.409  6.298   1.00 88.12  ? 254 SER B N   1 
ATOM 5545 C CA  . SER B 1 256 ? 71.369 -98.362  5.850   1.00 87.57  ? 254 SER B CA  1 
ATOM 5546 C C   . SER B 1 256 ? 70.726 -99.751  5.891   1.00 81.67  ? 254 SER B C   1 
ATOM 5547 O O   . SER B 1 256 ? 69.560 -99.894  6.259   1.00 87.21  ? 254 SER B O   1 
ATOM 5548 C CB  . SER B 1 256 ? 71.263 -97.736  4.469   1.00 86.01  ? 254 SER B CB  1 
ATOM 5549 O OG  . SER B 1 256 ? 71.749 -98.607  3.456   1.00 84.23  ? 254 SER B OG  1 
ATOM 5550 N N   . GLY B 1 257 ? 71.495 -100.769 5.495   1.00 71.81  ? 255 GLY B N   1 
ATOM 5551 C CA  . GLY B 1 257 ? 70.969 -102.114 5.365   1.00 74.04  ? 255 GLY B CA  1 
ATOM 5552 C C   . GLY B 1 257 ? 70.390 -102.363 3.975   1.00 78.53  ? 255 GLY B C   1 
ATOM 5553 O O   . GLY B 1 257 ? 69.669 -103.340 3.772   1.00 76.59  ? 255 GLY B O   1 
ATOM 5554 N N   . TYR B 1 258 ? 70.663 -101.434 3.049   1.00 89.87  ? 256 TYR B N   1 
ATOM 5555 C CA  . TYR B 1 258 ? 70.170 -101.529 1.684   1.00 94.16  ? 256 TYR B CA  1 
ATOM 5556 C C   . TYR B 1 258 ? 71.301 -101.941 0.750   1.00 90.51  ? 256 TYR B C   1 
ATOM 5557 O O   . TYR B 1 258 ? 72.452 -101.540 0.938   1.00 91.98  ? 256 TYR B O   1 
ATOM 5558 C CB  . TYR B 1 258 ? 69.546 -100.210 1.219   1.00 94.75  ? 256 TYR B CB  1 
ATOM 5559 C CG  . TYR B 1 258 ? 68.149 -100.045 1.792   1.00 86.89  ? 256 TYR B CG  1 
ATOM 5560 C CD1 . TYR B 1 258 ? 67.110 -100.847 1.331   1.00 81.96  ? 256 TYR B CD1 1 
ATOM 5561 C CD2 . TYR B 1 258 ? 67.890 -99.154  2.828   1.00 80.18  ? 256 TYR B CD2 1 
ATOM 5562 C CE1 . TYR B 1 258 ? 65.835 -100.738 1.856   1.00 80.28  ? 256 TYR B CE1 1 
ATOM 5563 C CE2 . TYR B 1 258 ? 66.616 -99.031  3.356   1.00 78.40  ? 256 TYR B CE2 1 
ATOM 5564 C CZ  . TYR B 1 258 ? 65.590 -99.820  2.862   1.00 83.42  ? 256 TYR B CZ  1 
ATOM 5565 O OH  . TYR B 1 258 ? 64.334 -99.718  3.372   1.00 102.80 ? 256 TYR B OH  1 
ATOM 5566 N N   . PRO B 1 259 ? 70.989 -102.729 -0.306  1.00 81.87  ? 257 PRO B N   1 
ATOM 5567 C CA  . PRO B 1 259 ? 71.988 -103.118 -1.305  1.00 78.34  ? 257 PRO B CA  1 
ATOM 5568 C C   . PRO B 1 259 ? 72.364 -101.981 -2.253  1.00 76.80  ? 257 PRO B C   1 
ATOM 5569 O O   . PRO B 1 259 ? 72.280 -102.123 -3.469  1.00 88.59  ? 257 PRO B O   1 
ATOM 5570 C CB  . PRO B 1 259 ? 71.294 -104.302 -2.016  1.00 76.71  ? 257 PRO B CB  1 
ATOM 5571 C CG  . PRO B 1 259 ? 69.810 -104.004 -1.898  1.00 75.99  ? 257 PRO B CG  1 
ATOM 5572 C CD  . PRO B 1 259 ? 69.654 -103.301 -0.566  1.00 77.82  ? 257 PRO B CD  1 
ATOM 5573 N N   . LEU B 1 260 ? 72.820 -100.865 -1.675  1.00 73.97  ? 258 LEU B N   1 
ATOM 5574 C CA  . LEU B 1 260 ? 73.219 -99.692  -2.433  1.00 79.64  ? 258 LEU B CA  1 
ATOM 5575 C C   . LEU B 1 260 ? 74.470 -100.013 -3.240  1.00 81.86  ? 258 LEU B C   1 
ATOM 5576 O O   . LEU B 1 260 ? 75.231 -100.911 -2.901  1.00 90.88  ? 258 LEU B O   1 
ATOM 5577 C CB  . LEU B 1 260 ? 73.477 -98.490  -1.529  1.00 79.92  ? 258 LEU B CB  1 
ATOM 5578 C CG  . LEU B 1 260 ? 72.360 -98.130  -0.550  1.00 88.76  ? 258 LEU B CG  1 
ATOM 5579 C CD1 . LEU B 1 260 ? 72.767 -96.895  0.238   1.00 89.68  ? 258 LEU B CD1 1 
ATOM 5580 C CD2 . LEU B 1 260 ? 71.033 -97.917  -1.263  1.00 97.50  ? 258 LEU B CD2 1 
ATOM 5581 N N   . VAL B 1 261 ? 74.664 -99.251  -4.312  1.00 87.92  ? 259 VAL B N   1 
ATOM 5582 C CA  . VAL B 1 261 ? 75.787 -99.446  -5.206  1.00 84.39  ? 259 VAL B CA  1 
ATOM 5583 C C   . VAL B 1 261 ? 76.129 -98.090  -5.813  1.00 87.10  ? 259 VAL B C   1 
ATOM 5584 O O   . VAL B 1 261 ? 75.237 -97.280  -6.031  1.00 95.89  ? 259 VAL B O   1 
ATOM 5585 C CB  . VAL B 1 261 ? 75.375 -100.495 -6.255  1.00 80.27  ? 259 VAL B CB  1 
ATOM 5586 C CG1 . VAL B 1 261 ? 74.320 -99.956  -7.212  1.00 81.04  ? 259 VAL B CG1 1 
ATOM 5587 C CG2 . VAL B 1 261 ? 76.572 -101.062 -7.007  1.00 87.16  ? 259 VAL B CG2 1 
ATOM 5588 N N   . GLY B 1 262 ? 77.417 -97.809  -6.022  1.00 91.34  ? 260 GLY B N   1 
ATOM 5589 C CA  . GLY B 1 262 ? 77.805 -96.592  -6.719  1.00 89.55  ? 260 GLY B CA  1 
ATOM 5590 C C   . GLY B 1 262 ? 77.280 -96.652  -8.150  1.00 99.02  ? 260 GLY B C   1 
ATOM 5591 O O   . GLY B 1 262 ? 77.395 -97.682  -8.805  1.00 114.73 ? 260 GLY B O   1 
ATOM 5592 N N   . ALA B 1 263 ? 76.634 -95.578  -8.607  1.00 114.82 ? 261 ALA B N   1 
ATOM 5593 C CA  . ALA B 1 263 ? 76.079 -95.549  -9.951  1.00 101.50 ? 261 ALA B CA  1 
ATOM 5594 C C   . ALA B 1 263 ? 77.242 -95.466  -10.931 1.00 101.37 ? 261 ALA B C   1 
ATOM 5595 O O   . ALA B 1 263 ? 78.216 -94.767  -10.656 1.00 93.84  ? 261 ALA B O   1 
ATOM 5596 C CB  . ALA B 1 263 ? 75.127 -94.381  -10.107 1.00 101.67 ? 261 ALA B CB  1 
ATOM 5597 N N   . GLU B 1 264 ? 77.123 -96.188  -12.053 1.00 106.06 ? 262 GLU B N   1 
ATOM 5598 C CA  . GLU B 1 264 ? 78.200 -96.331  -13.025 1.00 101.42 ? 262 GLU B CA  1 
ATOM 5599 C C   . GLU B 1 264 ? 78.644 -94.976  -13.572 1.00 104.13 ? 262 GLU B C   1 
ATOM 5600 O O   . GLU B 1 264 ? 79.839 -94.752  -13.747 1.00 117.43 ? 262 GLU B O   1 
ATOM 5601 C CB  . GLU B 1 264 ? 77.777 -97.300  -14.128 1.00 98.55  ? 262 GLU B CB  1 
ATOM 5602 C CG  . GLU B 1 264 ? 77.691 -98.729  -13.599 1.00 107.28 ? 262 GLU B CG  1 
ATOM 5603 C CD  . GLU B 1 264 ? 77.393 -99.823  -14.609 1.00 107.11 ? 262 GLU B CD  1 
ATOM 5604 O OE1 . GLU B 1 264 ? 77.168 -99.465  -15.788 1.00 108.45 ? 262 GLU B OE1 1 
ATOM 5605 O OE2 . GLU B 1 264 ? 77.393 -101.016 -14.213 1.00 92.96  ? 262 GLU B OE2 1 
ATOM 5606 N N   . ASN B 1 265 ? 77.687 -94.080  -13.835 1.00 96.09  ? 263 ASN B N   1 
ATOM 5607 C CA  . ASN B 1 265 ? 78.001 -92.720  -14.246 1.00 86.85  ? 263 ASN B CA  1 
ATOM 5608 C C   . ASN B 1 265 ? 77.518 -91.752  -13.169 1.00 84.30  ? 263 ASN B C   1 
ATOM 5609 O O   . ASN B 1 265 ? 76.347 -91.776  -12.815 1.00 82.11  ? 263 ASN B O   1 
ATOM 5610 C CB  . ASN B 1 265 ? 77.384 -92.427  -15.607 1.00 89.39  ? 263 ASN B CB  1 
ATOM 5611 C CG  . ASN B 1 265 ? 77.780 -91.078  -16.161 1.00 95.85  ? 263 ASN B CG  1 
ATOM 5612 O OD1 . ASN B 1 265 ? 77.728 -90.074  -15.446 1.00 95.86  ? 263 ASN B OD1 1 
ATOM 5613 N ND2 . ASN B 1 265 ? 78.181 -91.021  -17.425 1.00 102.37 ? 263 ASN B ND2 1 
ATOM 5614 N N   . LEU B 1 266 ? 78.421 -90.896  -12.667 1.00 85.39  ? 264 LEU B N   1 
ATOM 5615 C CA  . LEU B 1 266 ? 78.112 -89.966  -11.586 1.00 79.03  ? 264 LEU B CA  1 
ATOM 5616 C C   . LEU B 1 266 ? 77.525 -88.676  -12.148 1.00 77.10  ? 264 LEU B C   1 
ATOM 5617 O O   . LEU B 1 266 ? 76.676 -88.074  -11.507 1.00 86.79  ? 264 LEU B O   1 
ATOM 5618 C CB  . LEU B 1 266 ? 79.315 -89.683  -10.683 1.00 74.90  ? 264 LEU B CB  1 
ATOM 5619 C CG  . LEU B 1 266 ? 79.511 -90.685  -9.538  1.00 75.62  ? 264 LEU B CG  1 
ATOM 5620 C CD1 . LEU B 1 266 ? 79.932 -92.044  -10.061 1.00 76.10  ? 264 LEU B CD1 1 
ATOM 5621 C CD2 . LEU B 1 266 ? 80.505 -90.205  -8.489  1.00 77.50  ? 264 LEU B CD2 1 
ATOM 5622 N N   . VAL B 1 267 ? 77.958 -88.257  -13.339 1.00 75.94  ? 265 VAL B N   1 
ATOM 5623 C CA  . VAL B 1 267 ? 77.369 -87.094  -13.985 1.00 82.99  ? 265 VAL B CA  1 
ATOM 5624 C C   . VAL B 1 267 ? 75.888 -87.364  -14.257 1.00 87.00  ? 265 VAL B C   1 
ATOM 5625 O O   . VAL B 1 267 ? 75.041 -86.500  -14.020 1.00 90.52  ? 265 VAL B O   1 
ATOM 5626 C CB  . VAL B 1 267 ? 78.138 -86.695  -15.260 1.00 89.26  ? 265 VAL B CB  1 
ATOM 5627 C CG1 . VAL B 1 267 ? 77.313 -85.809  -16.187 1.00 96.14  ? 265 VAL B CG1 1 
ATOM 5628 C CG2 . VAL B 1 267 ? 79.464 -86.009  -14.927 1.00 86.64  ? 265 VAL B CG2 1 
ATOM 5629 N N   . ASP B 1 268 ? 75.607 -88.582  -14.734 1.00 84.94  ? 266 ASP B N   1 
ATOM 5630 C CA  . ASP B 1 268 ? 74.258 -89.049  -15.012 1.00 80.07  ? 266 ASP B CA  1 
ATOM 5631 C C   . ASP B 1 268 ? 73.401 -89.024  -13.747 1.00 79.36  ? 266 ASP B C   1 
ATOM 5632 O O   . ASP B 1 268 ? 72.339 -88.414  -13.736 1.00 77.89  ? 266 ASP B O   1 
ATOM 5633 C CB  . ASP B 1 268 ? 74.276 -90.426  -15.656 1.00 75.09  ? 266 ASP B CB  1 
ATOM 5634 C CG  . ASP B 1 268 ? 73.012 -91.254  -15.472 1.00 74.11  ? 266 ASP B CG  1 
ATOM 5635 O OD1 . ASP B 1 268 ? 71.918 -90.715  -15.701 1.00 75.73  ? 266 ASP B OD1 1 
ATOM 5636 O OD2 . ASP B 1 268 ? 73.130 -92.431  -15.095 1.00 76.20  ? 266 ASP B OD2 1 
ATOM 5637 N N   . ALA B 1 269 ? 73.859 -89.688  -12.681 1.00 76.16  ? 267 ALA B N   1 
ATOM 5638 C CA  . ALA B 1 269 ? 73.039 -89.838  -11.490 1.00 75.95  ? 267 ALA B CA  1 
ATOM 5639 C C   . ALA B 1 269 ? 72.924 -88.517  -10.730 1.00 73.28  ? 267 ALA B C   1 
ATOM 5640 O O   . ALA B 1 269 ? 72.188 -88.454  -9.756  1.00 71.90  ? 267 ALA B O   1 
ATOM 5641 C CB  . ALA B 1 269 ? 73.596 -90.924  -10.602 1.00 80.48  ? 267 ALA B CB  1 
ATOM 5642 N N   . THR B 1 270 ? 73.640 -87.476  -11.173 1.00 76.02  ? 268 THR B N   1 
ATOM 5643 C CA  . THR B 1 270 ? 73.629 -86.181  -10.507 1.00 87.48  ? 268 THR B CA  1 
ATOM 5644 C C   . THR B 1 270 ? 72.643 -85.223  -11.169 1.00 91.45  ? 268 THR B C   1 
ATOM 5645 O O   . THR B 1 270 ? 72.157 -84.298  -10.513 1.00 84.17  ? 268 THR B O   1 
ATOM 5646 C CB  . THR B 1 270 ? 75.039 -85.591  -10.512 1.00 85.09  ? 268 THR B CB  1 
ATOM 5647 O OG1 . THR B 1 270 ? 75.738 -86.475  -9.648  1.00 88.13  ? 268 THR B OG1 1 
ATOM 5648 C CG2 . THR B 1 270 ? 75.107 -84.181  -9.952  1.00 84.11  ? 268 THR B CG2 1 
ATOM 5649 N N   . GLN B 1 271 ? 72.383 -85.411  -12.470 1.00 96.11  ? 269 GLN B N   1 
ATOM 5650 C CA  . GLN B 1 271 ? 71.596 -84.434  -13.207 1.00 93.11  ? 269 GLN B CA  1 
ATOM 5651 C C   . GLN B 1 271 ? 70.222 -84.997  -13.589 1.00 88.64  ? 269 GLN B C   1 
ATOM 5652 O O   . GLN B 1 271 ? 69.315 -84.218  -13.891 1.00 105.82 ? 269 GLN B O   1 
ATOM 5653 C CB  . GLN B 1 271 ? 72.428 -83.784  -14.322 1.00 88.55  ? 269 GLN B CB  1 
ATOM 5654 C CG  . GLN B 1 271 ? 72.612 -84.582  -15.606 1.00 84.31  ? 269 GLN B CG  1 
ATOM 5655 C CD  . GLN B 1 271 ? 73.407 -83.806  -16.634 1.00 80.81  ? 269 GLN B CD  1 
ATOM 5656 O OE1 . GLN B 1 271 ? 72.935 -83.489  -17.736 1.00 72.64  ? 269 GLN B OE1 1 
ATOM 5657 N NE2 . GLN B 1 271 ? 74.623 -83.446  -16.247 1.00 84.10  ? 269 GLN B NE2 1 
ATOM 5658 N N   . ASN B 1 272 ? 70.038 -86.324  -13.534 1.00 75.59  ? 270 ASN B N   1 
ATOM 5659 C CA  . ASN B 1 272 ? 68.786 -86.915  -13.989 1.00 80.86  ? 270 ASN B CA  1 
ATOM 5660 C C   . ASN B 1 272 ? 67.932 -87.289  -12.775 1.00 71.80  ? 270 ASN B C   1 
ATOM 5661 O O   . ASN B 1 272 ? 68.416 -87.871  -11.813 1.00 65.01  ? 270 ASN B O   1 
ATOM 5662 C CB  . ASN B 1 272 ? 69.012 -88.072  -14.964 1.00 88.04  ? 270 ASN B CB  1 
ATOM 5663 C CG  . ASN B 1 272 ? 69.763 -87.668  -16.224 1.00 85.61  ? 270 ASN B CG  1 
ATOM 5664 O OD1 . ASN B 1 272 ? 69.558 -86.577  -16.768 1.00 84.27  ? 270 ASN B OD1 1 
ATOM 5665 N ND2 . ASN B 1 272 ? 70.645 -88.524  -16.719 1.00 79.27  ? 270 ASN B ND2 1 
ATOM 5666 N N   . THR B 1 273 ? 66.637 -86.962  -12.840 1.00 67.72  ? 271 THR B N   1 
ATOM 5667 C CA  . THR B 1 273 ? 65.736 -87.152  -11.718 1.00 62.18  ? 271 THR B CA  1 
ATOM 5668 C C   . THR B 1 273 ? 64.676 -88.185  -12.090 1.00 62.63  ? 271 THR B C   1 
ATOM 5669 O O   . THR B 1 273 ? 63.566 -88.152  -11.561 1.00 61.66  ? 271 THR B O   1 
ATOM 5670 C CB  . THR B 1 273 ? 65.133 -85.799  -11.328 1.00 63.57  ? 271 THR B CB  1 
ATOM 5671 O OG1 . THR B 1 273 ? 64.261 -85.319  -12.344 1.00 66.56  ? 271 THR B OG1 1 
ATOM 5672 C CG2 . THR B 1 273 ? 66.193 -84.725  -11.130 1.00 69.43  ? 271 THR B CG2 1 
ATOM 5673 N N   . ASP B 1 274 ? 65.040 -89.135  -12.958 1.00 63.79  ? 272 ASP B N   1 
ATOM 5674 C CA  . ASP B 1 274 ? 64.059 -90.027  -13.554 1.00 64.85  ? 272 ASP B CA  1 
ATOM 5675 C C   . ASP B 1 274 ? 63.715 -91.167  -12.599 1.00 63.16  ? 272 ASP B C   1 
ATOM 5676 O O   . ASP B 1 274 ? 62.702 -91.840  -12.773 1.00 60.86  ? 272 ASP B O   1 
ATOM 5677 C CB  . ASP B 1 274 ? 64.538 -90.557  -14.894 1.00 70.20  ? 272 ASP B CB  1 
ATOM 5678 C CG  . ASP B 1 274 ? 65.838 -91.347  -14.847 1.00 68.84  ? 272 ASP B CG  1 
ATOM 5679 O OD1 . ASP B 1 274 ? 66.848 -90.791  -14.359 1.00 65.20  ? 272 ASP B OD1 1 
ATOM 5680 O OD2 . ASP B 1 274 ? 65.821 -92.515  -15.283 1.00 65.91  ? 272 ASP B OD2 1 
ATOM 5681 N N   . ALA B 1 275 ? 64.570 -91.392  -11.597 1.00 69.43  ? 273 ALA B N   1 
ATOM 5682 C CA  . ALA B 1 275 ? 64.315 -92.431  -10.615 1.00 74.93  ? 273 ALA B CA  1 
ATOM 5683 C C   . ALA B 1 275 ? 63.076 -92.060  -9.815  1.00 71.28  ? 273 ALA B C   1 
ATOM 5684 O O   . ALA B 1 275 ? 62.296 -92.946  -9.473  1.00 65.89  ? 273 ALA B O   1 
ATOM 5685 C CB  . ALA B 1 275 ? 65.506 -92.612  -9.702  1.00 79.25  ? 273 ALA B CB  1 
ATOM 5686 N N   . TYR B 1 276 ? 62.941 -90.747  -9.551  1.00 67.66  ? 274 TYR B N   1 
ATOM 5687 C CA  . TYR B 1 276 ? 61.868 -90.189  -8.744  1.00 67.38  ? 274 TYR B CA  1 
ATOM 5688 C C   . TYR B 1 276 ? 60.567 -90.133  -9.547  1.00 66.10  ? 274 TYR B C   1 
ATOM 5689 O O   . TYR B 1 276 ? 59.505 -90.491  -9.041  1.00 66.76  ? 274 TYR B O   1 
ATOM 5690 C CB  . TYR B 1 276 ? 62.170 -88.774  -8.232  1.00 63.58  ? 274 TYR B CB  1 
ATOM 5691 C CG  . TYR B 1 276 ? 63.478 -88.558  -7.478  1.00 69.44  ? 274 TYR B CG  1 
ATOM 5692 C CD1 . TYR B 1 276 ? 64.024 -89.519  -6.631  1.00 71.05  ? 274 TYR B CD1 1 
ATOM 5693 C CD2 . TYR B 1 276 ? 64.167 -87.360  -7.603  1.00 76.87  ? 274 TYR B CD2 1 
ATOM 5694 C CE1 . TYR B 1 276 ? 65.223 -89.302  -5.963  1.00 71.66  ? 274 TYR B CE1 1 
ATOM 5695 C CE2 . TYR B 1 276 ? 65.357 -87.124  -6.927  1.00 82.18  ? 274 TYR B CE2 1 
ATOM 5696 C CZ  . TYR B 1 276 ? 65.899 -88.104  -6.116  1.00 74.79  ? 274 TYR B CZ  1 
ATOM 5697 O OH  . TYR B 1 276 ? 67.076 -87.840  -5.474  1.00 73.29  ? 274 TYR B OH  1 
ATOM 5698 N N   . THR B 1 277 ? 60.636 -89.654  -10.794 1.00 61.74  ? 275 THR B N   1 
ATOM 5699 C CA  . THR B 1 277 ? 59.439 -89.546  -11.613 1.00 62.07  ? 275 THR B CA  1 
ATOM 5700 C C   . THR B 1 277 ? 58.859 -90.938  -11.845 1.00 63.33  ? 275 THR B C   1 
ATOM 5701 O O   . THR B 1 277 ? 57.643 -91.076  -12.021 1.00 67.33  ? 275 THR B O   1 
ATOM 5702 C CB  . THR B 1 277 ? 59.725 -88.820  -12.930 1.00 68.59  ? 275 THR B CB  1 
ATOM 5703 O OG1 . THR B 1 277 ? 60.939 -89.285  -13.518 1.00 68.43  ? 275 THR B OG1 1 
ATOM 5704 C CG2 . THR B 1 277 ? 59.851 -87.321  -12.746 1.00 72.19  ? 275 THR B CG2 1 
ATOM 5705 N N   . GLU B 1 278 ? 59.752 -91.942  -11.833 1.00 64.32  ? 276 GLU B N   1 
ATOM 5706 C CA  . GLU B 1 278 ? 59.407 -93.332  -12.088 1.00 68.95  ? 276 GLU B CA  1 
ATOM 5707 C C   . GLU B 1 278 ? 58.601 -93.897  -10.924 1.00 68.21  ? 276 GLU B C   1 
ATOM 5708 O O   . GLU B 1 278 ? 57.593 -94.564  -11.134 1.00 63.27  ? 276 GLU B O   1 
ATOM 5709 C CB  . GLU B 1 278 ? 60.681 -94.147  -12.310 1.00 74.98  ? 276 GLU B CB  1 
ATOM 5710 C CG  . GLU B 1 278 ? 60.433 -95.637  -12.532 1.00 82.12  ? 276 GLU B CG  1 
ATOM 5711 C CD  . GLU B 1 278 ? 61.684 -96.481  -12.421 1.00 89.24  ? 276 GLU B CD  1 
ATOM 5712 O OE1 . GLU B 1 278 ? 61.524 -97.711  -12.509 1.00 97.22  ? 276 GLU B OE1 1 
ATOM 5713 O OE2 . GLU B 1 278 ? 62.791 -95.933  -12.224 1.00 96.27  ? 276 GLU B OE2 1 
ATOM 5714 N N   . VAL B 1 279 ? 59.071 -93.635  -9.703  1.00 70.33  ? 277 VAL B N   1 
ATOM 5715 C CA  . VAL B 1 279 ? 58.376 -94.068  -8.502  1.00 75.14  ? 277 VAL B CA  1 
ATOM 5716 C C   . VAL B 1 279 ? 57.004 -93.399  -8.440  1.00 79.15  ? 277 VAL B C   1 
ATOM 5717 O O   . VAL B 1 279 ? 55.993 -94.079  -8.276  1.00 73.02  ? 277 VAL B O   1 
ATOM 5718 C CB  . VAL B 1 279 ? 59.196 -93.776  -7.232  1.00 71.91  ? 277 VAL B CB  1 
ATOM 5719 C CG1 . VAL B 1 279 ? 58.382 -93.986  -5.969  1.00 70.86  ? 277 VAL B CG1 1 
ATOM 5720 C CG2 . VAL B 1 279 ? 60.457 -94.623  -7.176  1.00 76.47  ? 277 VAL B CG2 1 
ATOM 5721 N N   . SER B 1 280 ? 56.973 -92.066  -8.574  1.00 75.28  ? 278 SER B N   1 
ATOM 5722 C CA  . SER B 1 280 ? 55.712 -91.352  -8.530  1.00 63.28  ? 278 SER B CA  1 
ATOM 5723 C C   . SER B 1 280 ? 54.755 -91.972  -9.538  1.00 64.49  ? 278 SER B C   1 
ATOM 5724 O O   . SER B 1 280 ? 53.612 -92.273  -9.203  1.00 64.22  ? 278 SER B O   1 
ATOM 5725 C CB  . SER B 1 280 ? 55.873 -89.898  -8.790  1.00 59.02  ? 278 SER B CB  1 
ATOM 5726 O OG  . SER B 1 280 ? 54.638 -89.252  -8.521  1.00 63.79  ? 278 SER B OG  1 
ATOM 5727 N N   . ALA B 1 281 ? 55.248 -92.175  -10.764 1.00 62.89  ? 279 ALA B N   1 
ATOM 5728 C CA  . ALA B 1 281 ? 54.448 -92.773  -11.817 1.00 64.06  ? 279 ALA B CA  1 
ATOM 5729 C C   . ALA B 1 281 ? 53.763 -94.062  -11.352 1.00 66.74  ? 279 ALA B C   1 
ATOM 5730 O O   . ALA B 1 281 ? 52.557 -94.218  -11.559 1.00 63.14  ? 279 ALA B O   1 
ATOM 5731 C CB  . ALA B 1 281 ? 55.314 -93.002  -13.006 1.00 62.04  ? 279 ALA B CB  1 
ATOM 5732 N N   . ALA B 1 282 ? 54.526 -94.959  -10.706 1.00 67.86  ? 280 ALA B N   1 
ATOM 5733 C CA  . ALA B 1 282 ? 54.016 -96.246  -10.239 1.00 69.00  ? 280 ALA B CA  1 
ATOM 5734 C C   . ALA B 1 282 ? 52.925 -96.074  -9.183  1.00 68.46  ? 280 ALA B C   1 
ATOM 5735 O O   . ALA B 1 282 ? 51.984 -96.872  -9.110  1.00 67.55  ? 280 ALA B O   1 
ATOM 5736 C CB  . ALA B 1 282 ? 55.151 -97.079  -9.690  1.00 67.80  ? 280 ALA B CB  1 
ATOM 5737 N N   . LEU B 1 283 ? 53.090 -95.041  -8.353  1.00 67.13  ? 281 LEU B N   1 
ATOM 5738 C CA  . LEU B 1 283 ? 52.168 -94.762  -7.265  1.00 72.61  ? 281 LEU B CA  1 
ATOM 5739 C C   . LEU B 1 283 ? 50.868 -94.196  -7.825  1.00 67.28  ? 281 LEU B C   1 
ATOM 5740 O O   . LEU B 1 283 ? 49.786 -94.486  -7.317  1.00 65.54  ? 281 LEU B O   1 
ATOM 5741 C CB  . LEU B 1 283 ? 52.793 -93.768  -6.288  1.00 74.36  ? 281 LEU B CB  1 
ATOM 5742 C CG  . LEU B 1 283 ? 54.118 -94.175  -5.637  1.00 70.89  ? 281 LEU B CG  1 
ATOM 5743 C CD1 . LEU B 1 283 ? 54.696 -92.962  -4.946  1.00 70.13  ? 281 LEU B CD1 1 
ATOM 5744 C CD2 . LEU B 1 283 ? 53.969 -95.325  -4.661  1.00 66.33  ? 281 LEU B CD2 1 
ATOM 5745 N N   . LYS B 1 284 ? 50.993 -93.336  -8.839  1.00 61.38  ? 282 LYS B N   1 
ATOM 5746 C CA  . LYS B 1 284 ? 49.827 -92.698  -9.422  1.00 64.33  ? 282 LYS B CA  1 
ATOM 5747 C C   . LYS B 1 284 ? 48.934 -93.806  -9.954  1.00 60.47  ? 282 LYS B C   1 
ATOM 5748 O O   . LYS B 1 284 ? 47.770 -93.884  -9.590  1.00 58.92  ? 282 LYS B O   1 
ATOM 5749 C CB  . LYS B 1 284 ? 50.246 -91.695  -10.500 1.00 66.81  ? 282 LYS B CB  1 
ATOM 5750 C CG  . LYS B 1 284 ? 49.155 -90.970  -11.295 1.00 64.64  ? 282 LYS B CG  1 
ATOM 5751 C CD  . LYS B 1 284 ? 49.670 -90.328  -12.579 1.00 66.37  ? 282 LYS B CD  1 
ATOM 5752 C CE  . LYS B 1 284 ? 50.595 -91.281  -13.298 1.00 73.32  ? 282 LYS B CE  1 
ATOM 5753 N NZ  . LYS B 1 284 ? 50.835 -91.029  -14.714 1.00 75.98  ? 282 LYS B NZ  1 
ATOM 5754 N N   . VAL B 1 285 ? 49.522 -94.691  -10.760 1.00 61.45  ? 283 VAL B N   1 
ATOM 5755 C CA  . VAL B 1 285 ? 48.800 -95.841  -11.281 1.00 64.98  ? 283 VAL B CA  1 
ATOM 5756 C C   . VAL B 1 285 ? 48.070 -96.559  -10.150 1.00 68.48  ? 283 VAL B C   1 
ATOM 5757 O O   . VAL B 1 285 ? 46.884 -96.868  -10.260 1.00 56.78  ? 283 VAL B O   1 
ATOM 5758 C CB  . VAL B 1 285 ? 49.756 -96.809  -11.995 1.00 59.79  ? 283 VAL B CB  1 
ATOM 5759 C CG1 . VAL B 1 285 ? 49.051 -98.101  -12.399 1.00 58.07  ? 283 VAL B CG1 1 
ATOM 5760 C CG2 . VAL B 1 285 ? 50.400 -96.130  -13.192 1.00 58.64  ? 283 VAL B CG2 1 
ATOM 5761 N N   . CYS B 1 286 ? 48.820 -96.860  -9.086  1.00 74.27  ? 284 CYS B N   1 
ATOM 5762 C CA  . CYS B 1 286 ? 48.269 -97.570  -7.949  1.00 71.35  ? 284 CYS B CA  1 
ATOM 5763 C C   . CYS B 1 286 ? 46.978 -96.901  -7.489  1.00 64.25  ? 284 CYS B C   1 
ATOM 5764 O O   . CYS B 1 286 ? 45.937 -97.545  -7.424  1.00 67.72  ? 284 CYS B O   1 
ATOM 5765 C CB  . CYS B 1 286 ? 49.277 -97.648  -6.815  1.00 73.28  ? 284 CYS B CB  1 
ATOM 5766 S SG  . CYS B 1 286 ? 48.658 -98.618  -5.417  1.00 68.23  ? 284 CYS B SG  1 
ATOM 5767 N N   . MET B 1 287 ? 47.053 -95.596  -7.218  1.00 62.11  ? 285 MET B N   1 
ATOM 5768 C CA  . MET B 1 287 ? 45.930 -94.876  -6.643  1.00 66.99  ? 285 MET B CA  1 
ATOM 5769 C C   . MET B 1 287 ? 44.777 -94.732  -7.635  1.00 69.25  ? 285 MET B C   1 
ATOM 5770 O O   . MET B 1 287 ? 43.635 -94.650  -7.184  1.00 62.55  ? 285 MET B O   1 
ATOM 5771 C CB  . MET B 1 287 ? 46.356 -93.499  -6.129  1.00 66.80  ? 285 MET B CB  1 
ATOM 5772 C CG  . MET B 1 287 ? 47.301 -93.566  -4.948  1.00 70.41  ? 285 MET B CG  1 
ATOM 5773 S SD  . MET B 1 287 ? 46.704 -94.549  -3.549  1.00 73.04  ? 285 MET B SD  1 
ATOM 5774 C CE  . MET B 1 287 ? 45.024 -93.950  -3.310  1.00 68.08  ? 285 MET B CE  1 
ATOM 5775 N N   . MET B 1 288 ? 45.051 -94.704  -8.956  1.00 62.96  ? 286 MET B N   1 
ATOM 5776 C CA  . MET B 1 288 ? 43.960 -94.707  -9.920  1.00 59.20  ? 286 MET B CA  1 
ATOM 5777 C C   . MET B 1 288 ? 43.114 -95.948  -9.654  1.00 60.92  ? 286 MET B C   1 
ATOM 5778 O O   . MET B 1 288 ? 41.891 -95.865  -9.546  1.00 67.19  ? 286 MET B O   1 
ATOM 5779 C CB  . MET B 1 288 ? 44.395 -94.777  -11.391 1.00 67.78  ? 286 MET B CB  1 
ATOM 5780 C CG  . MET B 1 288 ? 45.367 -93.716  -11.876 1.00 79.89  ? 286 MET B CG  1 
ATOM 5781 S SD  . MET B 1 288 ? 45.216 -92.118  -11.057 1.00 109.84 ? 286 MET B SD  1 
ATOM 5782 C CE  . MET B 1 288 ? 43.532 -91.668  -11.486 1.00 115.71 ? 286 MET B CE  1 
ATOM 5783 N N   . ASN B 1 289 ? 43.794 -97.094  -9.518  1.00 57.18  ? 287 ASN B N   1 
ATOM 5784 C CA  . ASN B 1 289 ? 43.132 -98.371  -9.327  1.00 54.17  ? 287 ASN B CA  1 
ATOM 5785 C C   . ASN B 1 289 ? 42.333 -98.359  -8.029  1.00 56.80  ? 287 ASN B C   1 
ATOM 5786 O O   . ASN B 1 289 ? 41.182 -98.791  -8.003  1.00 57.00  ? 287 ASN B O   1 
ATOM 5787 C CB  . ASN B 1 289 ? 44.132 -99.517  -9.331  1.00 56.71  ? 287 ASN B CB  1 
ATOM 5788 C CG  . ASN B 1 289 ? 44.908 -99.577  -10.620 1.00 62.36  ? 287 ASN B CG  1 
ATOM 5789 O OD1 . ASN B 1 289 ? 44.437 -99.065  -11.638 1.00 63.54  ? 287 ASN B OD1 1 
ATOM 5790 N ND2 . ASN B 1 289 ? 46.075 -100.206 -10.606 1.00 69.93  ? 287 ASN B ND2 1 
ATOM 5791 N N   . MET B 1 290 ? 42.955 -97.860  -6.956  1.00 60.36  ? 288 MET B N   1 
ATOM 5792 C CA  . MET B 1 290 ? 42.362 -97.941  -5.631  1.00 65.35  ? 288 MET B CA  1 
ATOM 5793 C C   . MET B 1 290 ? 41.182 -96.979  -5.538  1.00 64.33  ? 288 MET B C   1 
ATOM 5794 O O   . MET B 1 290 ? 40.130 -97.309  -4.980  1.00 60.92  ? 288 MET B O   1 
ATOM 5795 C CB  . MET B 1 290 ? 43.385 -97.603  -4.541  1.00 67.35  ? 288 MET B CB  1 
ATOM 5796 C CG  . MET B 1 290 ? 44.595 -98.516  -4.515  1.00 77.20  ? 288 MET B CG  1 
ATOM 5797 S SD  . MET B 1 290 ? 44.212 -100.279 -4.547  1.00 94.78  ? 288 MET B SD  1 
ATOM 5798 C CE  . MET B 1 290 ? 42.863 -100.324 -3.355  1.00 76.05  ? 288 MET B CE  1 
ATOM 5799 N N   . SER B 1 291 ? 41.384 -95.781  -6.089  1.00 57.42  ? 289 SER B N   1 
ATOM 5800 C CA  . SER B 1 291 ? 40.338 -94.786  -6.131  1.00 56.38  ? 289 SER B CA  1 
ATOM 5801 C C   . SER B 1 291 ? 39.106 -95.392  -6.781  1.00 55.50  ? 289 SER B C   1 
ATOM 5802 O O   . SER B 1 291 ? 38.001 -95.166  -6.299  1.00 62.21  ? 289 SER B O   1 
ATOM 5803 C CB  . SER B 1 291 ? 40.785 -93.572  -6.860  1.00 60.09  ? 289 SER B CB  1 
ATOM 5804 O OG  . SER B 1 291 ? 39.798 -92.562  -6.783  1.00 67.09  ? 289 SER B OG  1 
ATOM 5805 N N   . LYS B 1 292 ? 39.314 -96.166  -7.857  1.00 51.65  ? 290 LYS B N   1 
ATOM 5806 C CA  . LYS B 1 292 ? 38.218 -96.867  -8.510  1.00 56.02  ? 290 LYS B CA  1 
ATOM 5807 C C   . LYS B 1 292 ? 37.572 -97.863  -7.542  1.00 59.56  ? 290 LYS B C   1 
ATOM 5808 O O   . LYS B 1 292 ? 36.374 -97.795  -7.247  1.00 52.91  ? 290 LYS B O   1 
ATOM 5809 C CB  . LYS B 1 292 ? 38.693 -97.557  -9.790  1.00 61.44  ? 290 LYS B CB  1 
ATOM 5810 C CG  . LYS B 1 292 ? 37.580 -98.072  -10.717 1.00 67.39  ? 290 LYS B CG  1 
ATOM 5811 C CD  . LYS B 1 292 ? 37.131 -99.504  -10.447 1.00 71.06  ? 290 LYS B CD  1 
ATOM 5812 C CE  . LYS B 1 292 ? 36.181 -100.055 -11.456 1.00 72.11  ? 290 LYS B CE  1 
ATOM 5813 N NZ  . LYS B 1 292 ? 36.043 -101.498 -11.229 1.00 78.48  ? 290 LYS B NZ  1 
ATOM 5814 N N   . ILE B 1 293 ? 38.375 -98.788  -7.020  1.00 64.67  ? 291 ILE B N   1 
ATOM 5815 C CA  . ILE B 1 293 ? 37.848 -99.801  -6.120  1.00 64.61  ? 291 ILE B CA  1 
ATOM 5816 C C   . ILE B 1 293 ? 37.058 -99.126  -4.999  1.00 66.18  ? 291 ILE B C   1 
ATOM 5817 O O   . ILE B 1 293 ? 35.982 -99.589  -4.627  1.00 65.32  ? 291 ILE B O   1 
ATOM 5818 C CB  . ILE B 1 293 ? 38.970 -100.691 -5.575  1.00 60.03  ? 291 ILE B CB  1 
ATOM 5819 C CG1 . ILE B 1 293 ? 39.693 -101.403 -6.705  1.00 63.15  ? 291 ILE B CG1 1 
ATOM 5820 C CG2 . ILE B 1 293 ? 38.407 -101.679 -4.556  1.00 58.94  ? 291 ILE B CG2 1 
ATOM 5821 C CD1 . ILE B 1 293 ? 41.061 -101.936 -6.323  1.00 69.23  ? 291 ILE B CD1 1 
ATOM 5822 N N   . ALA B 1 294 ? 37.589 -98.018  -4.478  1.00 64.95  ? 292 ALA B N   1 
ATOM 5823 C CA  . ALA B 1 294 ? 36.867 -97.230  -3.493  1.00 67.84  ? 292 ALA B CA  1 
ATOM 5824 C C   . ALA B 1 294 ? 35.493 -96.808  -4.026  1.00 68.36  ? 292 ALA B C   1 
ATOM 5825 O O   . ALA B 1 294 ? 34.479 -96.985  -3.346  1.00 64.03  ? 292 ALA B O   1 
ATOM 5826 C CB  . ALA B 1 294 ? 37.690 -96.032  -3.085  1.00 68.53  ? 292 ALA B CB  1 
ATOM 5827 N N   . ASN B 1 295 ? 35.461 -96.260  -5.249  1.00 63.76  ? 293 ASN B N   1 
ATOM 5828 C CA  . ASN B 1 295 ? 34.219 -95.765  -5.817  1.00 60.93  ? 293 ASN B CA  1 
ATOM 5829 C C   . ASN B 1 295 ? 33.222 -96.906  -5.946  1.00 71.54  ? 293 ASN B C   1 
ATOM 5830 O O   . ASN B 1 295 ? 32.030 -96.678  -5.748  1.00 85.18  ? 293 ASN B O   1 
ATOM 5831 C CB  . ASN B 1 295 ? 34.409 -95.058  -7.154  1.00 50.61  ? 293 ASN B CB  1 
ATOM 5832 C CG  . ASN B 1 295 ? 35.277 -93.831  -7.011  1.00 48.57  ? 293 ASN B CG  1 
ATOM 5833 O OD1 . ASN B 1 295 ? 35.060 -93.000  -6.120  1.00 52.54  ? 293 ASN B OD1 1 
ATOM 5834 N ND2 . ASN B 1 295 ? 36.280 -93.701  -7.863  1.00 46.96  ? 293 ASN B ND2 1 
ATOM 5835 N N   . ASP B 1 296 ? 33.719 -98.107  -6.282  1.00 72.75  ? 294 ASP B N   1 
ATOM 5836 C CA  . ASP B 1 296 ? 32.882 -99.294  -6.379  1.00 77.67  ? 294 ASP B CA  1 
ATOM 5837 C C   . ASP B 1 296 ? 32.204 -99.569  -5.039  1.00 76.19  ? 294 ASP B C   1 
ATOM 5838 O O   . ASP B 1 296 ? 30.986 -99.728  -4.976  1.00 78.08  ? 294 ASP B O   1 
ATOM 5839 C CB  . ASP B 1 296 ? 33.665 -100.515 -6.842  1.00 89.95  ? 294 ASP B CB  1 
ATOM 5840 C CG  . ASP B 1 296 ? 33.865 -100.646 -8.348  1.00 98.07  ? 294 ASP B CG  1 
ATOM 5841 O OD1 . ASP B 1 296 ? 33.563 -99.659  -9.056  1.00 96.95  ? 294 ASP B OD1 1 
ATOM 5842 O OD2 . ASP B 1 296 ? 34.285 -101.744 -8.810  1.00 100.46 ? 294 ASP B OD2 1 
ATOM 5843 N N   . LEU B 1 297 ? 33.002 -99.623  -3.968  1.00 72.76  ? 295 LEU B N   1 
ATOM 5844 C CA  . LEU B 1 297 ? 32.501 -100.026 -2.663  1.00 62.19  ? 295 LEU B CA  1 
ATOM 5845 C C   . LEU B 1 297 ? 31.431 -99.044  -2.200  1.00 60.68  ? 295 LEU B C   1 
ATOM 5846 O O   . LEU B 1 297 ? 30.398 -99.442  -1.678  1.00 62.30  ? 295 LEU B O   1 
ATOM 5847 C CB  . LEU B 1 297 ? 33.669 -100.125 -1.690  1.00 59.34  ? 295 LEU B CB  1 
ATOM 5848 C CG  . LEU B 1 297 ? 34.710 -101.196 -2.034  1.00 64.14  ? 295 LEU B CG  1 
ATOM 5849 C CD1 . LEU B 1 297 ? 35.960 -101.072 -1.183  1.00 71.46  ? 295 LEU B CD1 1 
ATOM 5850 C CD2 . LEU B 1 297 ? 34.121 -102.584 -1.878  1.00 65.09  ? 295 LEU B CD2 1 
ATOM 5851 N N   . ARG B 1 298 ? 31.668 -97.759  -2.454  1.00 63.07  ? 296 ARG B N   1 
ATOM 5852 C CA  . ARG B 1 298 ? 30.736 -96.715  -2.065  1.00 63.32  ? 296 ARG B CA  1 
ATOM 5853 C C   . ARG B 1 298 ? 29.411 -96.871  -2.804  1.00 64.89  ? 296 ARG B C   1 
ATOM 5854 O O   . ARG B 1 298 ? 28.362 -96.609  -2.232  1.00 78.85  ? 296 ARG B O   1 
ATOM 5855 C CB  . ARG B 1 298 ? 31.419 -95.367  -2.284  1.00 67.35  ? 296 ARG B CB  1 
ATOM 5856 C CG  . ARG B 1 298 ? 32.582 -95.170  -1.320  1.00 68.77  ? 296 ARG B CG  1 
ATOM 5857 C CD  . ARG B 1 298 ? 33.487 -94.030  -1.723  1.00 67.59  ? 296 ARG B CD  1 
ATOM 5858 N NE  . ARG B 1 298 ? 32.633 -92.879  -2.017  1.00 63.33  ? 296 ARG B NE  1 
ATOM 5859 C CZ  . ARG B 1 298 ? 32.500 -92.308  -3.206  1.00 62.48  ? 296 ARG B CZ  1 
ATOM 5860 N NH1 . ARG B 1 298 ? 33.407 -92.498  -4.160  1.00 65.96  ? 296 ARG B NH1 1 
ATOM 5861 N NH2 . ARG B 1 298 ? 31.459 -91.506  -3.405  1.00 57.66  ? 296 ARG B NH2 1 
ATOM 5862 N N   . LEU B 1 299 ? 29.464 -97.295  -4.072  1.00 69.80  ? 297 LEU B N   1 
ATOM 5863 C CA  . LEU B 1 299 ? 28.270 -97.623  -4.846  1.00 75.35  ? 297 LEU B CA  1 
ATOM 5864 C C   . LEU B 1 299 ? 27.509 -98.783  -4.204  1.00 72.29  ? 297 LEU B C   1 
ATOM 5865 O O   . LEU B 1 299 ? 26.319 -98.673  -3.898  1.00 72.39  ? 297 LEU B O   1 
ATOM 5866 C CB  . LEU B 1 299 ? 28.636 -98.001  -6.281  1.00 73.50  ? 297 LEU B CB  1 
ATOM 5867 C CG  . LEU B 1 299 ? 28.433 -96.945  -7.370  1.00 70.13  ? 297 LEU B CG  1 
ATOM 5868 C CD1 . LEU B 1 299 ? 28.883 -97.606  -8.658  1.00 75.15  ? 297 LEU B CD1 1 
ATOM 5869 C CD2 . LEU B 1 299 ? 27.000 -96.441  -7.515  1.00 66.05  ? 297 LEU B CD2 1 
ATOM 5870 N N   . MET B 1 300 ? 28.211 -99.908  -4.057  1.00 65.30  ? 298 MET B N   1 
ATOM 5871 C CA  . MET B 1 300 ? 27.586 -101.134 -3.605  1.00 64.71  ? 298 MET B CA  1 
ATOM 5872 C C   . MET B 1 300 ? 27.052 -100.933 -2.190  1.00 70.59  ? 298 MET B C   1 
ATOM 5873 O O   . MET B 1 300 ? 26.067 -101.556 -1.797  1.00 85.50  ? 298 MET B O   1 
ATOM 5874 C CB  . MET B 1 300 ? 28.571 -102.302 -3.697  1.00 60.79  ? 298 MET B CB  1 
ATOM 5875 C CG  . MET B 1 300 ? 28.730 -102.803 -5.112  1.00 58.49  ? 298 MET B CG  1 
ATOM 5876 S SD  . MET B 1 300 ? 29.782 -104.256 -5.257  1.00 66.91  ? 298 MET B SD  1 
ATOM 5877 C CE  . MET B 1 300 ? 31.374 -103.709 -4.622  1.00 60.95  ? 298 MET B CE  1 
ATOM 5878 N N   . ALA B 1 301 ? 27.687 -100.021 -1.449  1.00 69.61  ? 299 ALA B N   1 
ATOM 5879 C CA  . ALA B 1 301 ? 27.228 -99.686  -0.114  1.00 70.41  ? 299 ALA B CA  1 
ATOM 5880 C C   . ALA B 1 301 ? 26.254 -98.502  -0.151  1.00 67.78  ? 299 ALA B C   1 
ATOM 5881 O O   . ALA B 1 301 ? 25.889 -97.973  0.888   1.00 61.99  ? 299 ALA B O   1 
ATOM 5882 C CB  . ALA B 1 301 ? 28.429 -99.420  0.773   1.00 62.84  ? 299 ALA B CB  1 
ATOM 5883 N N   . SER B 1 302 ? 25.794 -98.080  -1.331  1.00 69.78  ? 300 SER B N   1 
ATOM 5884 C CA  . SER B 1 302 ? 24.827 -96.996  -1.373  1.00 77.03  ? 300 SER B CA  1 
ATOM 5885 C C   . SER B 1 302 ? 23.536 -97.499  -0.743  1.00 75.21  ? 300 SER B C   1 
ATOM 5886 O O   . SER B 1 302 ? 23.217 -98.677  -0.877  1.00 80.49  ? 300 SER B O   1 
ATOM 5887 C CB  . SER B 1 302 ? 24.612 -96.466  -2.776  1.00 82.80  ? 300 SER B CB  1 
ATOM 5888 O OG  . SER B 1 302 ? 24.160 -97.491  -3.646  1.00 93.88  ? 300 SER B OG  1 
ATOM 5889 N N   . GLY B 1 303 ? 22.840 -96.611  -0.025  1.00 70.34  ? 301 GLY B N   1 
ATOM 5890 C CA  . GLY B 1 303 ? 21.535 -96.935  0.523   1.00 80.48  ? 301 GLY B CA  1 
ATOM 5891 C C   . GLY B 1 303 ? 21.290 -96.208  1.842   1.00 87.89  ? 301 GLY B C   1 
ATOM 5892 O O   . GLY B 1 303 ? 21.682 -95.057  2.000   1.00 91.09  ? 301 GLY B O   1 
ATOM 5893 N N   . PRO B 1 304 ? 20.671 -96.855  2.853   1.00 84.88  ? 302 PRO B N   1 
ATOM 5894 C CA  . PRO B 1 304 ? 20.502 -98.304  2.860   1.00 74.45  ? 302 PRO B CA  1 
ATOM 5895 C C   . PRO B 1 304 ? 19.203 -98.816  2.258   1.00 73.99  ? 302 PRO B C   1 
ATOM 5896 O O   . PRO B 1 304 ? 18.962 -100.006 2.332   1.00 77.70  ? 302 PRO B O   1 
ATOM 5897 C CB  . PRO B 1 304 ? 20.557 -98.521  4.364   1.00 76.27  ? 302 PRO B CB  1 
ATOM 5898 C CG  . PRO B 1 304 ? 19.755 -97.367  4.922   1.00 72.50  ? 302 PRO B CG  1 
ATOM 5899 C CD  . PRO B 1 304 ? 20.095 -96.196  4.037   1.00 80.24  ? 302 PRO B CD  1 
ATOM 5900 N N   . ARG B 1 305 ? 18.369 -97.918  1.722   1.00 82.96  ? 303 ARG B N   1 
ATOM 5901 C CA  . ARG B 1 305 ? 17.062 -98.276  1.193   1.00 85.80  ? 303 ARG B CA  1 
ATOM 5902 C C   . ARG B 1 305 ? 16.968 -97.888  -0.279  1.00 84.17  ? 303 ARG B C   1 
ATOM 5903 O O   . ARG B 1 305 ? 16.629 -98.723  -1.114  1.00 86.83  ? 303 ARG B O   1 
ATOM 5904 C CB  . ARG B 1 305 ? 15.918 -97.567  1.932   1.00 92.91  ? 303 ARG B CB  1 
ATOM 5905 C CG  . ARG B 1 305 ? 15.749 -97.937  3.396   1.00 96.55  ? 303 ARG B CG  1 
ATOM 5906 C CD  . ARG B 1 305 ? 15.219 -99.362  3.566   1.00 99.57  ? 303 ARG B CD  1 
ATOM 5907 N NE  . ARG B 1 305 ? 14.616 -99.567  4.888   1.00 111.08 ? 303 ARG B NE  1 
ATOM 5908 C CZ  . ARG B 1 305 ? 13.551 -98.923  5.365   1.00 122.53 ? 303 ARG B CZ  1 
ATOM 5909 N NH1 . ARG B 1 305 ? 12.850 -98.104  4.603   1.00 127.24 ? 303 ARG B NH1 1 
ATOM 5910 N NH2 . ARG B 1 305 ? 13.176 -99.109  6.615   1.00 131.30 ? 303 ARG B NH2 1 
ATOM 5911 N N   . ALA B 1 306 ? 17.192 -96.598  -0.567  1.00 88.83  ? 304 ALA B N   1 
ATOM 5912 C CA  . ALA B 1 306 ? 17.101 -96.051  -1.917  1.00 92.63  ? 304 ALA B CA  1 
ATOM 5913 C C   . ALA B 1 306 ? 18.473 -96.069  -2.590  1.00 83.73  ? 304 ALA B C   1 
ATOM 5914 O O   . ALA B 1 306 ? 19.058 -95.029  -2.877  1.00 87.83  ? 304 ALA B O   1 
ATOM 5915 C CB  . ALA B 1 306 ? 16.539 -94.646  -1.868  1.00 93.90  ? 304 ALA B CB  1 
ATOM 5916 N N   . GLY B 1 307 ? 18.973 -97.276  -2.842  1.00 82.01  ? 305 GLY B N   1 
ATOM 5917 C CA  . GLY B 1 307 ? 20.335 -97.478  -3.295  1.00 75.33  ? 305 GLY B CA  1 
ATOM 5918 C C   . GLY B 1 307 ? 20.597 -98.966  -3.490  1.00 78.26  ? 305 GLY B C   1 
ATOM 5919 O O   . GLY B 1 307 ? 19.757 -99.804  -3.159  1.00 89.00  ? 305 GLY B O   1 
ATOM 5920 N N   . LEU B 1 308 ? 21.778 -99.277  -4.024  1.00 80.11  ? 306 LEU B N   1 
ATOM 5921 C CA  . LEU B 1 308 ? 22.127 -100.632 -4.418  1.00 89.19  ? 306 LEU B CA  1 
ATOM 5922 C C   . LEU B 1 308 ? 22.082 -101.582 -3.219  1.00 87.60  ? 306 LEU B C   1 
ATOM 5923 O O   . LEU B 1 308 ? 21.443 -102.633 -3.297  1.00 76.67  ? 306 LEU B O   1 
ATOM 5924 C CB  . LEU B 1 308 ? 23.494 -100.614 -5.107  1.00 94.82  ? 306 LEU B CB  1 
ATOM 5925 C CG  . LEU B 1 308 ? 23.492 -100.350 -6.622  1.00 86.10  ? 306 LEU B CG  1 
ATOM 5926 C CD1 . LEU B 1 308 ? 22.632 -99.178  -7.045  1.00 81.37  ? 306 LEU B CD1 1 
ATOM 5927 C CD2 . LEU B 1 308 ? 24.924 -100.161 -7.109  1.00 85.75  ? 306 LEU B CD2 1 
ATOM 5928 N N   . GLY B 1 309 ? 22.758 -101.207 -2.124  1.00 83.57  ? 307 GLY B N   1 
ATOM 5929 C CA  . GLY B 1 309 ? 22.641 -101.920 -0.859  1.00 79.51  ? 307 GLY B CA  1 
ATOM 5930 C C   . GLY B 1 309 ? 23.063 -103.383 -0.977  1.00 72.30  ? 307 GLY B C   1 
ATOM 5931 O O   . GLY B 1 309 ? 22.462 -104.272 -0.371  1.00 61.91  ? 307 GLY B O   1 
ATOM 5932 N N   . GLU B 1 310 ? 24.123 -103.609 -1.758  1.00 72.00  ? 308 GLU B N   1 
ATOM 5933 C CA  . GLU B 1 310 ? 24.655 -104.941 -1.978  1.00 75.53  ? 308 GLU B CA  1 
ATOM 5934 C C   . GLU B 1 310 ? 25.632 -105.326 -0.866  1.00 74.09  ? 308 GLU B C   1 
ATOM 5935 O O   . GLU B 1 310 ? 25.805 -106.516 -0.609  1.00 79.35  ? 308 GLU B O   1 
ATOM 5936 C CB  . GLU B 1 310 ? 25.315 -105.022 -3.355  1.00 85.48  ? 308 GLU B CB  1 
ATOM 5937 C CG  . GLU B 1 310 ? 24.334 -105.059 -4.527  1.00 88.31  ? 308 GLU B CG  1 
ATOM 5938 C CD  . GLU B 1 310 ? 24.982 -105.332 -5.880  1.00 97.46  ? 308 GLU B CD  1 
ATOM 5939 O OE1 . GLU B 1 310 ? 24.290 -105.854 -6.798  1.00 105.21 ? 308 GLU B OE1 1 
ATOM 5940 O OE2 . GLU B 1 310 ? 26.194 -105.001 -6.017  1.00 89.40  ? 308 GLU B OE2 1 
ATOM 5941 N N   . ILE B 1 311 ? 26.293 -104.337 -0.234  1.00 74.78  ? 309 ILE B N   1 
ATOM 5942 C CA  . ILE B 1 311 ? 27.191 -104.604 0.887   1.00 77.25  ? 309 ILE B CA  1 
ATOM 5943 C C   . ILE B 1 311 ? 26.965 -103.583 2.005   1.00 77.95  ? 309 ILE B C   1 
ATOM 5944 O O   . ILE B 1 311 ? 26.122 -102.687 1.885   1.00 73.56  ? 309 ILE B O   1 
ATOM 5945 C CB  . ILE B 1 311 ? 28.669 -104.646 0.443   1.00 74.35  ? 309 ILE B CB  1 
ATOM 5946 C CG1 . ILE B 1 311 ? 29.157 -103.290 -0.057  1.00 76.95  ? 309 ILE B CG1 1 
ATOM 5947 C CG2 . ILE B 1 311 ? 28.904 -105.740 -0.598  1.00 74.04  ? 309 ILE B CG2 1 
ATOM 5948 C CD1 . ILE B 1 311 ? 30.625 -103.269 -0.449  1.00 80.07  ? 309 ILE B CD1 1 
ATOM 5949 N N   . THR B 1 312 ? 27.714 -103.775 3.106   1.00 77.84  ? 310 THR B N   1 
ATOM 5950 C CA  . THR B 1 312 ? 27.779 -102.846 4.224   1.00 75.63  ? 310 THR B CA  1 
ATOM 5951 C C   . THR B 1 312 ? 29.221 -102.771 4.715   1.00 76.14  ? 310 THR B C   1 
ATOM 5952 O O   . THR B 1 312 ? 29.902 -103.789 4.848   1.00 70.72  ? 310 THR B O   1 
ATOM 5953 C CB  . THR B 1 312 ? 26.874 -103.314 5.360   1.00 73.56  ? 310 THR B CB  1 
ATOM 5954 O OG1 . THR B 1 312 ? 27.322 -104.649 5.572   1.00 72.42  ? 310 THR B OG1 1 
ATOM 5955 C CG2 . THR B 1 312 ? 25.392 -103.194 5.037   1.00 71.60  ? 310 THR B CG2 1 
ATOM 5956 N N   . LEU B 1 313 ? 29.668 -101.550 5.012   1.00 72.88  ? 311 LEU B N   1 
ATOM 5957 C CA  . LEU B 1 313 ? 31.019 -101.340 5.495   1.00 79.41  ? 311 LEU B CA  1 
ATOM 5958 C C   . LEU B 1 313 ? 30.948 -101.035 6.986   1.00 77.37  ? 311 LEU B C   1 
ATOM 5959 O O   . LEU B 1 313 ? 30.024 -100.358 7.423   1.00 81.17  ? 311 LEU B O   1 
ATOM 5960 C CB  . LEU B 1 313 ? 31.688 -100.184 4.747   1.00 93.06  ? 311 LEU B CB  1 
ATOM 5961 C CG  . LEU B 1 313 ? 31.539 -100.160 3.223   1.00 93.86  ? 311 LEU B CG  1 
ATOM 5962 C CD1 . LEU B 1 313 ? 32.220 -98.929  2.666   1.00 98.11  ? 311 LEU B CD1 1 
ATOM 5963 C CD2 . LEU B 1 313 ? 32.094 -101.420 2.605   1.00 99.83  ? 311 LEU B CD2 1 
ATOM 5964 N N   . PRO B 1 314 ? 31.955 -101.440 7.792   1.00 74.74  ? 312 PRO B N   1 
ATOM 5965 C CA  . PRO B 1 314 ? 32.014 -101.054 9.206   1.00 74.60  ? 312 PRO B CA  1 
ATOM 5966 C C   . PRO B 1 314 ? 31.712 -99.577  9.424   1.00 72.21  ? 312 PRO B C   1 
ATOM 5967 O O   . PRO B 1 314 ? 32.321 -98.736  8.778   1.00 76.95  ? 312 PRO B O   1 
ATOM 5968 C CB  . PRO B 1 314 ? 33.458 -101.383 9.574   1.00 74.65  ? 312 PRO B CB  1 
ATOM 5969 C CG  . PRO B 1 314 ? 33.793 -102.557 8.677   1.00 76.12  ? 312 PRO B CG  1 
ATOM 5970 C CD  . PRO B 1 314 ? 33.108 -102.245 7.367   1.00 72.96  ? 312 PRO B CD  1 
ATOM 5971 N N   . ALA B 1 315 ? 30.752 -99.270  10.304  1.00 71.40  ? 313 ALA B N   1 
ATOM 5972 C CA  . ALA B 1 315 ? 30.564 -97.903  10.766  1.00 65.05  ? 313 ALA B CA  1 
ATOM 5973 C C   . ALA B 1 315 ? 31.803 -97.499  11.548  1.00 63.96  ? 313 ALA B C   1 
ATOM 5974 O O   . ALA B 1 315 ? 32.344 -98.322  12.282  1.00 63.26  ? 313 ALA B O   1 
ATOM 5975 C CB  . ALA B 1 315 ? 29.331 -97.777  11.615  1.00 59.64  ? 313 ALA B CB  1 
ATOM 5976 N N   . ARG B 1 316 ? 32.278 -96.273  11.323  1.00 61.80  ? 314 ARG B N   1 
ATOM 5977 C CA  . ARG B 1 316 ? 33.476 -95.806  11.991  1.00 61.30  ? 314 ARG B CA  1 
ATOM 5978 C C   . ARG B 1 316 ? 33.235 -94.457  12.637  1.00 65.72  ? 314 ARG B C   1 
ATOM 5979 O O   . ARG B 1 316 ? 34.077 -94.012  13.415  1.00 83.93  ? 314 ARG B O   1 
ATOM 5980 C CB  . ARG B 1 316 ? 34.677 -95.691  11.052  1.00 61.85  ? 314 ARG B CB  1 
ATOM 5981 C CG  . ARG B 1 316 ? 35.192 -97.016  10.513  1.00 60.88  ? 314 ARG B CG  1 
ATOM 5982 C CD  . ARG B 1 316 ? 35.692 -97.931  11.585  1.00 60.98  ? 314 ARG B CD  1 
ATOM 5983 N NE  . ARG B 1 316 ? 36.843 -97.339  12.270  1.00 65.47  ? 314 ARG B NE  1 
ATOM 5984 C CZ  . ARG B 1 316 ? 37.589 -98.016  13.130  1.00 82.64  ? 314 ARG B CZ  1 
ATOM 5985 N NH1 . ARG B 1 316 ? 37.291 -99.279  13.400  1.00 88.48  ? 314 ARG B NH1 1 
ATOM 5986 N NH2 . ARG B 1 316 ? 38.649 -97.446  13.687  1.00 87.47  ? 314 ARG B NH2 1 
ATOM 5987 N N   . GLN B 1 317 ? 32.112 -93.811  12.323  1.00 63.71  ? 315 GLN B N   1 
ATOM 5988 C CA  . GLN B 1 317 ? 31.781 -92.578  13.015  1.00 74.53  ? 315 GLN B CA  1 
ATOM 5989 C C   . GLN B 1 317 ? 30.356 -92.197  12.659  1.00 74.13  ? 315 GLN B C   1 
ATOM 5990 O O   . GLN B 1 317 ? 29.819 -92.712  11.692  1.00 87.58  ? 315 GLN B O   1 
ATOM 5991 C CB  . GLN B 1 317 ? 32.771 -91.445  12.718  1.00 89.89  ? 315 GLN B CB  1 
ATOM 5992 C CG  . GLN B 1 317 ? 33.086 -91.209  11.241  1.00 95.15  ? 315 GLN B CG  1 
ATOM 5993 C CD  . GLN B 1 317 ? 33.891 -89.954  10.982  1.00 90.35  ? 315 GLN B CD  1 
ATOM 5994 O OE1 . GLN B 1 317 ? 33.431 -89.039  10.276  1.00 85.41  ? 315 GLN B OE1 1 
ATOM 5995 N NE2 . GLN B 1 317 ? 35.097 -89.916  11.547  1.00 78.61  ? 315 GLN B NE2 1 
ATOM 5996 N N   . PRO B 1 318 ? 29.694 -91.313  13.434  1.00 85.61  ? 316 PRO B N   1 
ATOM 5997 C CA  . PRO B 1 318 ? 28.434 -90.713  12.997  1.00 95.74  ? 316 PRO B CA  1 
ATOM 5998 C C   . PRO B 1 318 ? 28.724 -90.014  11.677  1.00 109.98 ? 316 PRO B C   1 
ATOM 5999 O O   . PRO B 1 318 ? 29.594 -89.151  11.623  1.00 124.42 ? 316 PRO B O   1 
ATOM 6000 C CB  . PRO B 1 318 ? 28.054 -89.735  14.105  1.00 93.39  ? 316 PRO B CB  1 
ATOM 6001 C CG  . PRO B 1 318 ? 28.846 -90.232  15.297  1.00 99.70  ? 316 PRO B CG  1 
ATOM 6002 C CD  . PRO B 1 318 ? 30.134 -90.823  14.745  1.00 90.77  ? 316 PRO B CD  1 
ATOM 6003 N N   . GLY B 1 319 ? 28.025 -90.425  10.617  1.00 120.19 ? 317 GLY B N   1 
ATOM 6004 C CA  . GLY B 1 319 ? 28.343 -89.955  9.280   1.00 125.95 ? 317 GLY B CA  1 
ATOM 6005 C C   . GLY B 1 319 ? 27.872 -88.521  9.063   1.00 131.68 ? 317 GLY B C   1 
ATOM 6006 O O   . GLY B 1 319 ? 28.516 -87.787  8.314   1.00 115.71 ? 317 GLY B O   1 
ATOM 6007 N N   . SER B 1 320 ? 26.764 -88.155  9.741   1.00 138.80 ? 318 SER B N   1 
ATOM 6008 C CA  . SER B 1 320 ? 26.080 -86.880  9.567   1.00 154.64 ? 318 SER B CA  1 
ATOM 6009 C C   . SER B 1 320 ? 25.804 -86.209  10.911  1.00 158.82 ? 318 SER B C   1 
ATOM 6010 O O   . SER B 1 320 ? 25.797 -86.866  11.953  1.00 156.50 ? 318 SER B O   1 
ATOM 6011 C CB  . SER B 1 320 ? 24.784 -87.059  8.829   1.00 158.38 ? 318 SER B CB  1 
ATOM 6012 O OG  . SER B 1 320 ? 24.077 -85.834  8.688   1.00 154.54 ? 318 SER B OG  1 
ATOM 6013 N N   . SER B 1 321 ? 25.512 -84.900  10.836  1.00 160.07 ? 319 SER B N   1 
ATOM 6014 C CA  . SER B 1 321 ? 25.247 -84.058  11.994  1.00 150.31 ? 319 SER B CA  1 
ATOM 6015 C C   . SER B 1 321 ? 23.747 -83.972  12.309  1.00 171.38 ? 319 SER B C   1 
ATOM 6016 O O   . SER B 1 321 ? 23.410 -83.842  13.487  1.00 190.73 ? 319 SER B O   1 
ATOM 6017 C CB  . SER B 1 321 ? 25.874 -82.686  11.825  1.00 122.00 ? 319 SER B CB  1 
ATOM 6018 O OG  . SER B 1 321 ? 25.739 -82.211  10.494  1.00 100.17 ? 319 SER B OG  1 
ATOM 6019 N N   . ILE B 1 322 ? 22.858 -84.071  11.293  1.00 159.36 ? 320 ILE B N   1 
ATOM 6020 C CA  . ILE B 1 322 ? 21.416 -83.916  11.525  1.00 125.36 ? 320 ILE B CA  1 
ATOM 6021 C C   . ILE B 1 322 ? 20.632 -85.198  11.215  1.00 125.14 ? 320 ILE B C   1 
ATOM 6022 O O   . ILE B 1 322 ? 19.563 -85.377  11.788  1.00 121.24 ? 320 ILE B O   1 
ATOM 6023 C CB  . ILE B 1 322 ? 20.776 -82.680  10.838  1.00 110.66 ? 320 ILE B CB  1 
ATOM 6024 C CG1 . ILE B 1 322 ? 20.227 -82.940  9.422   1.00 112.46 ? 320 ILE B CG1 1 
ATOM 6025 C CG2 . ILE B 1 322 ? 21.705 -81.465  10.868  1.00 117.18 ? 320 ILE B CG2 1 
ATOM 6026 C CD1 . ILE B 1 322 ? 19.185 -81.930  8.961   1.00 106.70 ? 320 ILE B CD1 1 
ATOM 6027 N N   . ILE B 1 323 ? 21.097 -86.066  10.303  1.00 136.29 ? 321 ILE B N   1 
ATOM 6028 C CA  . ILE B 1 323 ? 20.351 -87.283  9.993   1.00 138.14 ? 321 ILE B CA  1 
ATOM 6029 C C   . ILE B 1 323 ? 20.685 -88.349  11.029  1.00 129.57 ? 321 ILE B C   1 
ATOM 6030 O O   . ILE B 1 323 ? 21.839 -88.774  11.116  1.00 120.10 ? 321 ILE B O   1 
ATOM 6031 C CB  . ILE B 1 323 ? 20.616 -87.822  8.573   1.00 151.45 ? 321 ILE B CB  1 
ATOM 6032 C CG1 . ILE B 1 323 ? 20.353 -86.772  7.487   1.00 165.64 ? 321 ILE B CG1 1 
ATOM 6033 C CG2 . ILE B 1 323 ? 19.812 -89.103  8.328   1.00 135.98 ? 321 ILE B CG2 1 
ATOM 6034 C CD1 . ILE B 1 323 ? 18.966 -86.154  7.532   1.00 172.84 ? 321 ILE B CD1 1 
ATOM 6035 N N   . PRO B 1 324 ? 19.696 -88.816  11.831  1.00 133.71 ? 322 PRO B N   1 
ATOM 6036 C CA  . PRO B 1 324 ? 19.931 -89.922  12.760  1.00 143.53 ? 322 PRO B CA  1 
ATOM 6037 C C   . PRO B 1 324 ? 20.138 -91.248  12.029  1.00 141.89 ? 322 PRO B C   1 
ATOM 6038 O O   . PRO B 1 324 ? 19.351 -91.611  11.154  1.00 130.24 ? 322 PRO B O   1 
ATOM 6039 C CB  . PRO B 1 324 ? 18.673 -89.930  13.664  1.00 139.32 ? 322 PRO B CB  1 
ATOM 6040 C CG  . PRO B 1 324 ? 17.968 -88.611  13.370  1.00 131.45 ? 322 PRO B CG  1 
ATOM 6041 C CD  . PRO B 1 324 ? 18.325 -88.282  11.933  1.00 125.55 ? 322 PRO B CD  1 
ATOM 6042 N N   . GLY B 1 325 ? 21.121 -92.019  12.486  1.00 143.69 ? 323 GLY B N   1 
ATOM 6043 C CA  . GLY B 1 325 ? 21.337 -93.348  11.892  1.00 144.57 ? 323 GLY B CA  1 
ATOM 6044 C C   . GLY B 1 325 ? 21.996 -93.200  10.546  1.00 157.69 ? 323 GLY B C   1 
ATOM 6045 O O   . GLY B 1 325 ? 21.530 -93.842  9.585   1.00 159.35 ? 323 GLY B O   1 
ATOM 6046 N N   . MET B 1 326 ? 23.040 -92.374  10.483  1.00 162.91 ? 324 MET B N   1 
ATOM 6047 C CA  . MET B 1 326 ? 23.752 -92.151  9.204   1.00 140.34 ? 324 MET B CA  1 
ATOM 6048 C C   . MET B 1 326 ? 25.100 -92.873  9.250   1.00 124.83 ? 324 MET B C   1 
ATOM 6049 O O   . MET B 1 326 ? 25.918 -92.536  10.128  1.00 97.62  ? 324 MET B O   1 
ATOM 6050 C CB  . MET B 1 326 ? 23.993 -90.659  8.968   1.00 30.00  ? 324 MET B CB  1 
ATOM 6051 C CG  . MET B 1 326 ? 24.550 -90.352  7.601   1.00 30.00  ? 324 MET B CG  1 
ATOM 6052 S SD  . MET B 1 326 ? 23.271 -90.336  6.332   1.00 30.00  ? 324 MET B SD  1 
ATOM 6053 C CE  . MET B 1 326 ? 23.652 -88.765  5.546   1.00 30.00  ? 324 MET B CE  1 
ATOM 6054 N N   . VAL B 1 327 ? 25.305 -93.839  8.357   1.00 104.79 ? 325 VAL B N   1 
ATOM 6055 C CA  . VAL B 1 327 ? 26.639 -94.498  8.273   1.00 97.75  ? 325 VAL B CA  1 
ATOM 6056 C C   . VAL B 1 327 ? 27.201 -94.190  6.885   1.00 88.11  ? 325 VAL B C   1 
ATOM 6057 O O   . VAL B 1 327 ? 26.635 -94.693  5.896   1.00 86.29  ? 325 VAL B O   1 
ATOM 6058 C CB  . VAL B 1 327 ? 26.603 -96.013  8.530   1.00 107.99 ? 325 VAL B CB  1 
ATOM 6059 C CG1 . VAL B 1 327 ? 27.924 -96.679  8.168   1.00 114.25 ? 325 VAL B CG1 1 
ATOM 6060 C CG2 . VAL B 1 327 ? 26.224 -96.321  9.972   1.00 107.92 ? 325 VAL B CG2 1 
ATOM 6061 N N   . CYS B 1 328 ? 28.257 -93.387  6.829   1.00 84.66  ? 326 CYS B N   1 
ATOM 6062 C CA  . CYS B 1 328 ? 28.864 -93.011  5.571   1.00 76.34  ? 326 CYS B CA  1 
ATOM 6063 C C   . CYS B 1 328 ? 30.132 -93.833  5.342   1.00 69.90  ? 326 CYS B C   1 
ATOM 6064 O O   . CYS B 1 328 ? 30.813 -94.253  6.279   1.00 59.25  ? 326 CYS B O   1 
ATOM 6065 C CB  . CYS B 1 328 ? 29.079 -91.505  5.574   1.00 73.71  ? 326 CYS B CB  1 
ATOM 6066 S SG  . CYS B 1 328 ? 27.510 -90.611  5.739   1.00 67.81  ? 326 CYS B SG  1 
ATOM 6067 N N   . PRO B 1 329 ? 30.483 -94.095  4.067   1.00 65.90  ? 327 PRO B N   1 
ATOM 6068 C CA  . PRO B 1 329 ? 31.610 -94.967  3.753   1.00 73.15  ? 327 PRO B CA  1 
ATOM 6069 C C   . PRO B 1 329 ? 32.925 -94.201  3.867   1.00 80.40  ? 327 PRO B C   1 
ATOM 6070 O O   . PRO B 1 329 ? 33.616 -93.982  2.874   1.00 98.05  ? 327 PRO B O   1 
ATOM 6071 C CB  . PRO B 1 329 ? 31.244 -95.369  2.314   1.00 64.59  ? 327 PRO B CB  1 
ATOM 6072 C CG  . PRO B 1 329 ? 30.624 -94.111  1.726   1.00 62.04  ? 327 PRO B CG  1 
ATOM 6073 C CD  . PRO B 1 329 ? 29.810 -93.566  2.869   1.00 62.69  ? 327 PRO B CD  1 
ATOM 6074 N N   . VAL B 1 330 ? 33.254 -93.752  5.079   1.00 71.33  ? 328 VAL B N   1 
ATOM 6075 C CA  . VAL B 1 330 ? 34.257 -92.711  5.211   1.00 67.38  ? 328 VAL B CA  1 
ATOM 6076 C C   . VAL B 1 330 ? 35.650 -93.271  4.963   1.00 66.83  ? 328 VAL B C   1 
ATOM 6077 O O   . VAL B 1 330 ? 36.552 -92.516  4.610   1.00 70.92  ? 328 VAL B O   1 
ATOM 6078 C CB  . VAL B 1 330 ? 34.226 -92.020  6.577   1.00 66.43  ? 328 VAL B CB  1 
ATOM 6079 C CG1 . VAL B 1 330 ? 32.867 -91.373  6.832   1.00 67.55  ? 328 VAL B CG1 1 
ATOM 6080 C CG2 . VAL B 1 330 ? 34.651 -92.995  7.670   1.00 65.12  ? 328 VAL B CG2 1 
ATOM 6081 N N   . MET B 1 331 ? 35.856 -94.569  5.191   1.00 69.20  ? 329 MET B N   1 
ATOM 6082 C CA  . MET B 1 331 ? 37.192 -95.102  4.979   1.00 72.70  ? 329 MET B CA  1 
ATOM 6083 C C   . MET B 1 331 ? 37.511 -95.118  3.482   1.00 72.20  ? 329 MET B C   1 
ATOM 6084 O O   . MET B 1 331 ? 38.596 -94.713  3.072   1.00 65.08  ? 329 MET B O   1 
ATOM 6085 C CB  . MET B 1 331 ? 37.340 -96.474  5.635   1.00 71.09  ? 329 MET B CB  1 
ATOM 6086 C CG  . MET B 1 331 ? 37.222 -96.430  7.148   1.00 66.23  ? 329 MET B CG  1 
ATOM 6087 S SD  . MET B 1 331 ? 38.163 -95.092  7.909   1.00 63.60  ? 329 MET B SD  1 
ATOM 6088 C CE  . MET B 1 331 ? 39.880 -95.548  7.648   1.00 58.51  ? 329 MET B CE  1 
ATOM 6089 N N   . ALA B 1 332 ? 36.556 -95.544  2.654   1.00 79.63  ? 330 ALA B N   1 
ATOM 6090 C CA  . ALA B 1 332 ? 36.733 -95.457  1.211   1.00 83.47  ? 330 ALA B CA  1 
ATOM 6091 C C   . ALA B 1 332 ? 36.957 -94.006  0.769   1.00 74.66  ? 330 ALA B C   1 
ATOM 6092 O O   . ALA B 1 332 ? 37.837 -93.721  -0.042  1.00 66.11  ? 330 ALA B O   1 
ATOM 6093 C CB  . ALA B 1 332 ? 35.536 -96.072  0.527   1.00 85.64  ? 330 ALA B CB  1 
ATOM 6094 N N   . GLU B 1 333 ? 36.149 -93.092  1.317   1.00 66.14  ? 331 GLU B N   1 
ATOM 6095 C CA  . GLU B 1 333 ? 36.190 -91.697  0.923   1.00 60.22  ? 331 GLU B CA  1 
ATOM 6096 C C   . GLU B 1 333 ? 37.600 -91.167  1.111   1.00 51.42  ? 331 GLU B C   1 
ATOM 6097 O O   . GLU B 1 333 ? 38.076 -90.387  0.305   1.00 48.16  ? 331 GLU B O   1 
ATOM 6098 C CB  . GLU B 1 333 ? 35.236 -90.807  1.721   1.00 71.13  ? 331 GLU B CB  1 
ATOM 6099 C CG  . GLU B 1 333 ? 33.760 -91.101  1.463   1.00 79.06  ? 331 GLU B CG  1 
ATOM 6100 C CD  . GLU B 1 333 ? 32.771 -90.187  2.166   1.00 72.34  ? 331 GLU B CD  1 
ATOM 6101 O OE1 . GLU B 1 333 ? 33.262 -89.288  2.889   1.00 74.10  ? 331 GLU B OE1 1 
ATOM 6102 O OE2 . GLU B 1 333 ? 31.539 -90.340  1.949   1.00 62.42  ? 331 GLU B OE2 1 
ATOM 6103 N N   . VAL B 1 334 ? 38.263 -91.567  2.189   1.00 56.21  ? 332 VAL B N   1 
ATOM 6104 C CA  . VAL B 1 334 ? 39.558 -90.985  2.484   1.00 64.95  ? 332 VAL B CA  1 
ATOM 6105 C C   . VAL B 1 334 ? 40.527 -91.501  1.423   1.00 63.29  ? 332 VAL B C   1 
ATOM 6106 O O   . VAL B 1 334 ? 41.355 -90.734  0.944   1.00 65.64  ? 332 VAL B O   1 
ATOM 6107 C CB  . VAL B 1 334 ? 40.058 -91.206  3.932   1.00 74.09  ? 332 VAL B CB  1 
ATOM 6108 C CG1 . VAL B 1 334 ? 40.589 -92.610  4.181   1.00 74.43  ? 332 VAL B CG1 1 
ATOM 6109 C CG2 . VAL B 1 334 ? 41.121 -90.189  4.330   1.00 77.83  ? 332 VAL B CG2 1 
ATOM 6110 N N   . ILE B 1 335 ? 40.366 -92.767  1.007   1.00 62.47  ? 333 ILE B N   1 
ATOM 6111 C CA  . ILE B 1 335 ? 41.177 -93.327  -0.066  1.00 62.28  ? 333 ILE B CA  1 
ATOM 6112 C C   . ILE B 1 335 ? 41.015 -92.507  -1.350  1.00 59.80  ? 333 ILE B C   1 
ATOM 6113 O O   . ILE B 1 335 ? 42.004 -92.138  -1.981  1.00 55.69  ? 333 ILE B O   1 
ATOM 6114 C CB  . ILE B 1 335 ? 40.842 -94.812  -0.285  1.00 68.71  ? 333 ILE B CB  1 
ATOM 6115 C CG1 . ILE B 1 335 ? 41.434 -95.678  0.805   1.00 77.10  ? 333 ILE B CG1 1 
ATOM 6116 C CG2 . ILE B 1 335 ? 41.322 -95.291  -1.655  1.00 72.63  ? 333 ILE B CG2 1 
ATOM 6117 C CD1 . ILE B 1 335 ? 42.929 -95.893  0.651   1.00 79.79  ? 333 ILE B CD1 1 
ATOM 6118 N N   . ASN B 1 336 ? 39.770 -92.229  -1.748  1.00 58.90  ? 334 ASN B N   1 
ATOM 6119 C CA  . ASN B 1 336 ? 39.507 -91.374  -2.898  1.00 60.62  ? 334 ASN B CA  1 
ATOM 6120 C C   . ASN B 1 336 ? 40.346 -90.099  -2.803  1.00 56.79  ? 334 ASN B C   1 
ATOM 6121 O O   . ASN B 1 336 ? 41.026 -89.726  -3.753  1.00 66.60  ? 334 ASN B O   1 
ATOM 6122 C CB  . ASN B 1 336 ? 38.025 -91.018  -3.038  1.00 72.88  ? 334 ASN B CB  1 
ATOM 6123 C CG  . ASN B 1 336 ? 37.161 -92.170  -3.509  1.00 77.73  ? 334 ASN B CG  1 
ATOM 6124 O OD1 . ASN B 1 336 ? 37.454 -92.769  -4.547  1.00 89.13  ? 334 ASN B OD1 1 
ATOM 6125 N ND2 . ASN B 1 336 ? 36.094 -92.489  -2.789  1.00 67.64  ? 334 ASN B ND2 1 
ATOM 6126 N N   . GLN B 1 337 ? 40.304 -89.444  -1.638  1.00 54.78  ? 335 GLN B N   1 
ATOM 6127 C CA  . GLN B 1 337 ? 40.892 -88.126  -1.460  1.00 53.44  ? 335 GLN B CA  1 
ATOM 6128 C C   . GLN B 1 337 ? 42.403 -88.212  -1.534  1.00 46.98  ? 335 GLN B C   1 
ATOM 6129 O O   . GLN B 1 337 ? 43.039 -87.346  -2.116  1.00 56.53  ? 335 GLN B O   1 
ATOM 6130 C CB  . GLN B 1 337 ? 40.520 -87.487  -0.124  1.00 57.60  ? 335 GLN B CB  1 
ATOM 6131 C CG  . GLN B 1 337 ? 39.040 -87.134  -0.034  1.00 64.29  ? 335 GLN B CG  1 
ATOM 6132 C CD  . GLN B 1 337 ? 38.688 -86.292  1.171   1.00 72.74  ? 335 GLN B CD  1 
ATOM 6133 O OE1 . GLN B 1 337 ? 39.335 -85.276  1.453   1.00 82.46  ? 335 GLN B OE1 1 
ATOM 6134 N NE2 . GLN B 1 337 ? 37.642 -86.687  1.884   1.00 82.71  ? 335 GLN B NE2 1 
ATOM 6135 N N   . ILE B 1 338 ? 42.963 -89.239  -0.911  1.00 45.02  ? 336 ILE B N   1 
ATOM 6136 C CA  . ILE B 1 338 ? 44.387 -89.510  -1.009  1.00 48.88  ? 336 ILE B CA  1 
ATOM 6137 C C   . ILE B 1 338 ? 44.798 -89.626  -2.474  1.00 49.81  ? 336 ILE B C   1 
ATOM 6138 O O   . ILE B 1 338 ? 45.797 -89.036  -2.882  1.00 55.74  ? 336 ILE B O   1 
ATOM 6139 C CB  . ILE B 1 338 ? 44.735 -90.785  -0.226  1.00 53.46  ? 336 ILE B CB  1 
ATOM 6140 C CG1 . ILE B 1 338 ? 44.720 -90.510  1.275   1.00 51.89  ? 336 ILE B CG1 1 
ATOM 6141 C CG2 . ILE B 1 338 ? 46.062 -91.391  -0.704  1.00 57.84  ? 336 ILE B CG2 1 
ATOM 6142 C CD1 . ILE B 1 338 ? 44.759 -91.767  2.123   1.00 53.53  ? 336 ILE B CD1 1 
ATOM 6143 N N   . ALA B 1 339 ? 44.053 -90.415  -3.256  1.00 49.58  ? 337 ALA B N   1 
ATOM 6144 C CA  . ALA B 1 339 ? 44.400 -90.600  -4.655  1.00 53.30  ? 337 ALA B CA  1 
ATOM 6145 C C   . ALA B 1 339 ? 44.565 -89.238  -5.315  1.00 57.80  ? 337 ALA B C   1 
ATOM 6146 O O   . ALA B 1 339 ? 45.569 -88.999  -5.971  1.00 62.15  ? 337 ALA B O   1 
ATOM 6147 C CB  . ALA B 1 339 ? 43.363 -91.427  -5.361  1.00 56.20  ? 337 ALA B CB  1 
ATOM 6148 N N   . PHE B 1 340 ? 43.605 -88.335  -5.077  1.00 62.67  ? 338 PHE B N   1 
ATOM 6149 C CA  . PHE B 1 340 ? 43.629 -87.006  -5.672  1.00 64.86  ? 338 PHE B CA  1 
ATOM 6150 C C   . PHE B 1 340 ? 44.914 -86.266  -5.298  1.00 59.05  ? 338 PHE B C   1 
ATOM 6151 O O   . PHE B 1 340 ? 45.480 -85.568  -6.142  1.00 62.63  ? 338 PHE B O   1 
ATOM 6152 C CB  . PHE B 1 340 ? 42.374 -86.212  -5.291  1.00 65.04  ? 338 PHE B CB  1 
ATOM 6153 C CG  . PHE B 1 340 ? 41.047 -86.901  -5.594  1.00 63.31  ? 338 PHE B CG  1 
ATOM 6154 C CD1 . PHE B 1 340 ? 40.963 -87.981  -6.471  1.00 56.29  ? 338 PHE B CD1 1 
ATOM 6155 C CD2 . PHE B 1 340 ? 39.873 -86.459  -4.990  1.00 66.10  ? 338 PHE B CD2 1 
ATOM 6156 C CE1 . PHE B 1 340 ? 39.748 -88.591  -6.728  1.00 56.45  ? 338 PHE B CE1 1 
ATOM 6157 C CE2 . PHE B 1 340 ? 38.659 -87.079  -5.256  1.00 61.54  ? 338 PHE B CE2 1 
ATOM 6158 C CZ  . PHE B 1 340 ? 38.598 -88.143  -6.122  1.00 56.05  ? 338 PHE B CZ  1 
ATOM 6159 N N   . GLN B 1 341 ? 45.360 -86.404  -4.046  1.00 52.75  ? 339 GLN B N   1 
ATOM 6160 C CA  . GLN B 1 341 ? 46.661 -85.887  -3.645  1.00 64.67  ? 339 GLN B CA  1 
ATOM 6161 C C   . GLN B 1 341 ? 47.768 -86.458  -4.528  1.00 68.13  ? 339 GLN B C   1 
ATOM 6162 O O   . GLN B 1 341 ? 48.473 -85.716  -5.210  1.00 79.96  ? 339 GLN B O   1 
ATOM 6163 C CB  . GLN B 1 341 ? 47.090 -86.270  -2.227  1.00 66.77  ? 339 GLN B CB  1 
ATOM 6164 C CG  . GLN B 1 341 ? 46.734 -85.241  -1.164  1.00 65.25  ? 339 GLN B CG  1 
ATOM 6165 C CD  . GLN B 1 341 ? 47.431 -83.922  -1.373  1.00 59.98  ? 339 GLN B CD  1 
ATOM 6166 O OE1 . GLN B 1 341 ? 46.818 -82.860  -1.250  1.00 59.94  ? 339 GLN B OE1 1 
ATOM 6167 N NE2 . GLN B 1 341 ? 48.716 -83.990  -1.686  1.00 61.31  ? 339 GLN B NE2 1 
ATOM 6168 N N   . VAL B 1 342 ? 47.914 -87.785  -4.487  1.00 64.10  ? 340 VAL B N   1 
ATOM 6169 C CA  . VAL B 1 342 ? 49.060 -88.469  -5.062  1.00 64.02  ? 340 VAL B CA  1 
ATOM 6170 C C   . VAL B 1 342 ? 49.241 -88.039  -6.514  1.00 69.30  ? 340 VAL B C   1 
ATOM 6171 O O   . VAL B 1 342 ? 50.374 -87.871  -6.984  1.00 73.57  ? 340 VAL B O   1 
ATOM 6172 C CB  . VAL B 1 342 ? 48.860 -89.991  -4.967  1.00 67.42  ? 340 VAL B CB  1 
ATOM 6173 C CG1 . VAL B 1 342 ? 49.887 -90.746  -5.803  1.00 74.16  ? 340 VAL B CG1 1 
ATOM 6174 C CG2 . VAL B 1 342 ? 48.891 -90.468  -3.524  1.00 78.14  ? 340 VAL B CG2 1 
ATOM 6175 N N   . ILE B 1 343 ? 48.092 -87.895  -7.195  1.00 64.26  ? 341 ILE B N   1 
ATOM 6176 C CA  . ILE B 1 343 ? 48.032 -87.576  -8.608  1.00 59.90  ? 341 ILE B CA  1 
ATOM 6177 C C   . ILE B 1 343 ? 48.553 -86.164  -8.779  1.00 55.87  ? 341 ILE B C   1 
ATOM 6178 O O   . ILE B 1 343 ? 49.578 -85.976  -9.424  1.00 63.40  ? 341 ILE B O   1 
ATOM 6179 C CB  . ILE B 1 343 ? 46.609 -87.739  -9.172  1.00 63.40  ? 341 ILE B CB  1 
ATOM 6180 C CG1 . ILE B 1 343 ? 46.132 -89.187  -9.052  1.00 71.42  ? 341 ILE B CG1 1 
ATOM 6181 C CG2 . ILE B 1 343 ? 46.553 -87.280  -10.629 1.00 62.91  ? 341 ILE B CG2 1 
ATOM 6182 C CD1 . ILE B 1 343 ? 44.625 -89.351  -9.019  1.00 70.88  ? 341 ILE B CD1 1 
ATOM 6183 N N   . GLY B 1 344 ? 47.856 -85.201  -8.169  1.00 50.99  ? 342 GLY B N   1 
ATOM 6184 C CA  . GLY B 1 344 ? 48.309 -83.820  -8.144  1.00 51.89  ? 342 GLY B CA  1 
ATOM 6185 C C   . GLY B 1 344 ? 49.792 -83.703  -7.787  1.00 53.85  ? 342 GLY B C   1 
ATOM 6186 O O   . GLY B 1 344 ? 50.502 -82.897  -8.374  1.00 51.22  ? 342 GLY B O   1 
ATOM 6187 N N   . ASN B 1 345 ? 50.252 -84.511  -6.828  1.00 56.78  ? 343 ASN B N   1 
ATOM 6188 C CA  . ASN B 1 345 ? 51.654 -84.541  -6.444  1.00 65.96  ? 343 ASN B CA  1 
ATOM 6189 C C   . ASN B 1 345 ? 52.527 -85.028  -7.595  1.00 64.39  ? 343 ASN B C   1 
ATOM 6190 O O   . ASN B 1 345 ? 53.601 -84.486  -7.829  1.00 66.10  ? 343 ASN B O   1 
ATOM 6191 C CB  . ASN B 1 345 ? 51.882 -85.383  -5.195  1.00 69.48  ? 343 ASN B CB  1 
ATOM 6192 C CG  . ASN B 1 345 ? 51.248 -84.739  -3.985  1.00 69.02  ? 343 ASN B CG  1 
ATOM 6193 O OD1 . ASN B 1 345 ? 50.307 -83.948  -4.123  1.00 74.57  ? 343 ASN B OD1 1 
ATOM 6194 N ND2 . ASN B 1 345 ? 51.736 -85.064  -2.800  1.00 65.08  ? 343 ASN B ND2 1 
ATOM 6195 N N   . ASP B 1 346 ? 52.069 -86.045  -8.317  1.00 64.07  ? 344 ASP B N   1 
ATOM 6196 C CA  . ASP B 1 346 ? 52.818 -86.520  -9.467  1.00 64.32  ? 344 ASP B CA  1 
ATOM 6197 C C   . ASP B 1 346 ? 53.039 -85.377  -10.460 1.00 62.66  ? 344 ASP B C   1 
ATOM 6198 O O   . ASP B 1 346 ? 54.102 -85.311  -11.073 1.00 59.84  ? 344 ASP B O   1 
ATOM 6199 C CB  . ASP B 1 346 ? 52.171 -87.762  -10.065 1.00 65.71  ? 344 ASP B CB  1 
ATOM 6200 C CG  . ASP B 1 346 ? 52.863 -88.358  -11.282 1.00 68.23  ? 344 ASP B CG  1 
ATOM 6201 O OD1 . ASP B 1 346 ? 53.965 -88.964  -11.144 1.00 78.41  ? 344 ASP B OD1 1 
ATOM 6202 O OD2 . ASP B 1 346 ? 52.291 -88.203  -12.373 1.00 84.49  ? 344 ASP B OD2 1 
ATOM 6203 N N   . HIS B 1 347 ? 52.052 -84.472  -10.608 1.00 64.48  ? 345 HIS B N   1 
ATOM 6204 C CA  . HIS B 1 347 ? 52.138 -83.404  -11.599 1.00 66.19  ? 345 HIS B CA  1 
ATOM 6205 C C   . HIS B 1 347 ? 53.194 -82.406  -11.136 1.00 59.99  ? 345 HIS B C   1 
ATOM 6206 O O   . HIS B 1 347 ? 54.002 -81.949  -11.931 1.00 60.51  ? 345 HIS B O   1 
ATOM 6207 C CB  . HIS B 1 347 ? 50.760 -82.832  -11.971 1.00 76.60  ? 345 HIS B CB  1 
ATOM 6208 C CG  . HIS B 1 347 ? 49.792 -83.898  -12.413 1.00 119.95 ? 345 HIS B CG  1 
ATOM 6209 N ND1 . HIS B 1 347 ? 50.246 -85.155  -12.765 1.00 159.69 ? 345 HIS B ND1 1 
ATOM 6210 C CD2 . HIS B 1 347 ? 48.444 -83.967  -12.519 1.00 151.04 ? 345 HIS B CD2 1 
ATOM 6211 C CE1 . HIS B 1 347 ? 49.219 -85.933  -13.087 1.00 164.66 ? 345 HIS B CE1 1 
ATOM 6212 N NE2 . HIS B 1 347 ? 48.116 -85.229  -12.947 1.00 169.05 ? 345 HIS B NE2 1 
ATOM 6213 N N   . THR B 1 348 ? 53.218 -82.135  -9.830  1.00 57.89  ? 346 THR B N   1 
ATOM 6214 C CA  . THR B 1 348 ? 54.248 -81.319  -9.217  1.00 52.29  ? 346 THR B CA  1 
ATOM 6215 C C   . THR B 1 348 ? 55.610 -81.956  -9.439  1.00 55.51  ? 346 THR B C   1 
ATOM 6216 O O   . THR B 1 348 ? 56.518 -81.303  -9.922  1.00 71.67  ? 346 THR B O   1 
ATOM 6217 C CB  . THR B 1 348 ? 53.972 -81.186  -7.731  1.00 56.04  ? 346 THR B CB  1 
ATOM 6218 O OG1 . THR B 1 348 ? 52.657 -80.649  -7.661  1.00 68.18  ? 346 THR B OG1 1 
ATOM 6219 C CG2 . THR B 1 348 ? 54.952 -80.242  -7.064  1.00 65.61  ? 346 THR B CG2 1 
ATOM 6220 N N   . ILE B 1 349 ? 55.750 -83.222  -9.057  1.00 58.32  ? 347 ILE B N   1 
ATOM 6221 C CA  . ILE B 1 349 ? 56.994 -83.954  -9.233  1.00 60.14  ? 347 ILE B CA  1 
ATOM 6222 C C   . ILE B 1 349 ? 57.455 -83.856  -10.685 1.00 61.46  ? 347 ILE B C   1 
ATOM 6223 O O   . ILE B 1 349 ? 58.615 -83.549  -10.948 1.00 57.03  ? 347 ILE B O   1 
ATOM 6224 C CB  . ILE B 1 349 ? 56.816 -85.419  -8.784  1.00 65.21  ? 347 ILE B CB  1 
ATOM 6225 C CG1 . ILE B 1 349 ? 56.766 -85.514  -7.271  1.00 69.36  ? 347 ILE B CG1 1 
ATOM 6226 C CG2 . ILE B 1 349 ? 57.909 -86.322  -9.351  1.00 67.97  ? 347 ILE B CG2 1 
ATOM 6227 C CD1 . ILE B 1 349 ? 56.147 -86.789  -6.746  1.00 75.02  ? 347 ILE B CD1 1 
ATOM 6228 N N   . CYS B 1 350 ? 56.543 -84.131  -11.623 1.00 65.05  ? 348 CYS B N   1 
ATOM 6229 C CA  . CYS B 1 350 ? 56.911 -84.200  -13.027 1.00 66.16  ? 348 CYS B CA  1 
ATOM 6230 C C   . CYS B 1 350 ? 57.409 -82.827  -13.480 1.00 57.85  ? 348 CYS B C   1 
ATOM 6231 O O   . CYS B 1 350 ? 58.515 -82.719  -14.000 1.00 50.40  ? 348 CYS B O   1 
ATOM 6232 C CB  . CYS B 1 350 ? 55.796 -84.843  -13.853 1.00 68.46  ? 348 CYS B CB  1 
ATOM 6233 S SG  . CYS B 1 350 ? 55.822 -86.656  -13.777 1.00 74.39  ? 348 CYS B SG  1 
ATOM 6234 N N   . LEU B 1 351 ? 56.611 -81.783  -13.234 1.00 55.83  ? 349 LEU B N   1 
ATOM 6235 C CA  . LEU B 1 351 ? 57.005 -80.415  -13.532 1.00 59.60  ? 349 LEU B CA  1 
ATOM 6236 C C   . LEU B 1 351 ? 58.420 -80.130  -13.049 1.00 66.16  ? 349 LEU B C   1 
ATOM 6237 O O   . LEU B 1 351 ? 59.197 -79.487  -13.754 1.00 87.19  ? 349 LEU B O   1 
ATOM 6238 C CB  . LEU B 1 351 ? 56.056 -79.430  -12.865 1.00 61.33  ? 349 LEU B CB  1 
ATOM 6239 C CG  . LEU B 1 351 ? 54.836 -78.995  -13.680 1.00 64.53  ? 349 LEU B CG  1 
ATOM 6240 C CD1 . LEU B 1 351 ? 54.040 -77.997  -12.849 1.00 63.85  ? 349 LEU B CD1 1 
ATOM 6241 C CD2 . LEU B 1 351 ? 55.220 -78.377  -15.010 1.00 64.98  ? 349 LEU B CD2 1 
ATOM 6242 N N   . ALA B 1 352 ? 58.697 -80.537  -11.809 1.00 64.92  ? 350 ALA B N   1 
ATOM 6243 C CA  . ALA B 1 352 ? 59.947 -80.215  -11.143 1.00 58.71  ? 350 ALA B CA  1 
ATOM 6244 C C   . ALA B 1 352 ? 61.077 -80.994  -11.792 1.00 59.24  ? 350 ALA B C   1 
ATOM 6245 O O   . ALA B 1 352 ? 62.160 -80.465  -12.017 1.00 71.64  ? 350 ALA B O   1 
ATOM 6246 C CB  . ALA B 1 352 ? 59.833 -80.543  -9.679  1.00 62.11  ? 350 ALA B CB  1 
ATOM 6247 N N   . SER B 1 353 ? 60.787 -82.255  -12.105 1.00 57.72  ? 351 SER B N   1 
ATOM 6248 C CA  . SER B 1 353 ? 61.759 -83.140  -12.717 1.00 58.99  ? 351 SER B CA  1 
ATOM 6249 C C   . SER B 1 353 ? 62.188 -82.605  -14.081 1.00 57.93  ? 351 SER B C   1 
ATOM 6250 O O   . SER B 1 353 ? 63.353 -82.714  -14.452 1.00 58.57  ? 351 SER B O   1 
ATOM 6251 C CB  . SER B 1 353 ? 61.189 -84.517  -12.824 1.00 59.04  ? 351 SER B CB  1 
ATOM 6252 O OG  . SER B 1 353 ? 61.963 -85.315  -13.702 1.00 60.69  ? 351 SER B OG  1 
ATOM 6253 N N   . GLU B 1 354 ? 61.231 -82.008  -14.800 1.00 58.13  ? 352 GLU B N   1 
ATOM 6254 C CA  . GLU B 1 354 ? 61.445 -81.489  -16.143 1.00 62.18  ? 352 GLU B CA  1 
ATOM 6255 C C   . GLU B 1 354 ? 62.273 -80.205  -16.123 1.00 62.28  ? 352 GLU B C   1 
ATOM 6256 O O   . GLU B 1 354 ? 63.029 -79.941  -17.056 1.00 64.26  ? 352 GLU B O   1 
ATOM 6257 C CB  . GLU B 1 354 ? 60.061 -81.261  -16.752 1.00 63.95  ? 352 GLU B CB  1 
ATOM 6258 C CG  . GLU B 1 354 ? 60.053 -81.034  -18.261 1.00 64.84  ? 352 GLU B CG  1 
ATOM 6259 C CD  . GLU B 1 354 ? 60.082 -79.583  -18.660 1.00 66.96  ? 352 GLU B CD  1 
ATOM 6260 O OE1 . GLU B 1 354 ? 60.109 -78.702  -17.773 1.00 73.71  ? 352 GLU B OE1 1 
ATOM 6261 O OE2 . GLU B 1 354 ? 60.074 -79.355  -19.876 1.00 68.12  ? 352 GLU B OE2 1 
ATOM 6262 N N   . ALA B 1 355 ? 62.135 -79.420  -15.050 1.00 63.40  ? 353 ALA B N   1 
ATOM 6263 C CA  . ALA B 1 355 ? 62.697 -78.080  -14.990 1.00 64.34  ? 353 ALA B CA  1 
ATOM 6264 C C   . ALA B 1 355 ? 64.222 -78.115  -14.890 1.00 67.91  ? 353 ALA B C   1 
ATOM 6265 O O   . ALA B 1 355 ? 64.864 -77.069  -14.999 1.00 74.49  ? 353 ALA B O   1 
ATOM 6266 C CB  . ALA B 1 355 ? 62.085 -77.315  -13.837 1.00 61.62  ? 353 ALA B CB  1 
ATOM 6267 N N   . GLY B 1 356 ? 64.789 -79.310  -14.687 1.00 65.33  ? 354 GLY B N   1 
ATOM 6268 C CA  . GLY B 1 356 ? 66.234 -79.471  -14.632 1.00 71.12  ? 354 GLY B CA  1 
ATOM 6269 C C   . GLY B 1 356 ? 66.963 -78.738  -15.759 1.00 62.88  ? 354 GLY B C   1 
ATOM 6270 O O   . GLY B 1 356 ? 66.478 -78.682  -16.880 1.00 62.84  ? 354 GLY B O   1 
ATOM 6271 N N   . GLN B 1 357 ? 68.131 -78.186  -15.435 1.00 61.52  ? 355 GLN B N   1 
ATOM 6272 C CA  . GLN B 1 357 ? 68.945 -77.430  -16.372 1.00 66.18  ? 355 GLN B CA  1 
ATOM 6273 C C   . GLN B 1 357 ? 70.405 -77.859  -16.211 1.00 74.15  ? 355 GLN B C   1 
ATOM 6274 O O   . GLN B 1 357 ? 70.989 -77.694  -15.140 1.00 77.84  ? 355 GLN B O   1 
ATOM 6275 C CB  . GLN B 1 357 ? 68.849 -75.916  -16.158 1.00 61.79  ? 355 GLN B CB  1 
ATOM 6276 C CG  . GLN B 1 357 ? 67.518 -75.263  -16.522 1.00 63.13  ? 355 GLN B CG  1 
ATOM 6277 C CD  . GLN B 1 357 ? 67.372 -73.862  -15.944 1.00 62.70  ? 355 GLN B CD  1 
ATOM 6278 O OE1 . GLN B 1 357 ? 67.890 -73.534  -14.875 1.00 77.39  ? 355 GLN B OE1 1 
ATOM 6279 N NE2 . GLN B 1 357 ? 66.620 -72.997  -16.594 1.00 59.09  ? 355 GLN B NE2 1 
ATOM 6280 N N   . LEU B 1 358 ? 70.966 -78.426  -17.292 1.00 82.38  ? 356 LEU B N   1 
ATOM 6281 C CA  . LEU B 1 358 ? 72.366 -78.805  -17.393 1.00 74.44  ? 356 LEU B CA  1 
ATOM 6282 C C   . LEU B 1 358 ? 72.726 -79.742  -16.240 1.00 77.15  ? 356 LEU B C   1 
ATOM 6283 O O   . LEU B 1 358 ? 72.099 -80.790  -16.121 1.00 79.35  ? 356 LEU B O   1 
ATOM 6284 C CB  . LEU B 1 358 ? 73.230 -77.546  -17.496 1.00 78.90  ? 356 LEU B CB  1 
ATOM 6285 C CG  . LEU B 1 358 ? 72.996 -76.673  -18.738 1.00 83.03  ? 356 LEU B CG  1 
ATOM 6286 C CD1 . LEU B 1 358 ? 73.725 -75.340  -18.676 1.00 87.94  ? 356 LEU B CD1 1 
ATOM 6287 C CD2 . LEU B 1 358 ? 73.420 -77.420  -19.987 1.00 87.35  ? 356 LEU B CD2 1 
ATOM 6288 N N   . GLU B 1 359 ? 73.703 -79.384  -15.385 1.00 81.41  ? 357 GLU B N   1 
ATOM 6289 C CA  . GLU B 1 359 ? 74.349 -80.388  -14.544 1.00 82.69  ? 357 GLU B CA  1 
ATOM 6290 C C   . GLU B 1 359 ? 73.564 -80.643  -13.261 1.00 77.77  ? 357 GLU B C   1 
ATOM 6291 O O   . GLU B 1 359 ? 73.911 -81.581  -12.557 1.00 73.75  ? 357 GLU B O   1 
ATOM 6292 C CB  . GLU B 1 359 ? 75.778 -80.132  -14.062 1.00 83.32  ? 357 GLU B CB  1 
ATOM 6293 C CG  . GLU B 1 359 ? 76.592 -79.187  -14.940 1.00 86.45  ? 357 GLU B CG  1 
ATOM 6294 C CD  . GLU B 1 359 ? 76.601 -79.447  -16.426 1.00 88.85  ? 357 GLU B CD  1 
ATOM 6295 O OE1 . GLU B 1 359 ? 76.431 -80.611  -16.864 1.00 96.58  ? 357 GLU B OE1 1 
ATOM 6296 O OE2 . GLU B 1 359 ? 76.763 -78.428  -17.134 1.00 90.76  ? 357 GLU B OE2 1 
ATOM 6297 N N   . LEU B 1 360 ? 72.533 -79.830  -12.965 1.00 80.58  ? 358 LEU B N   1 
ATOM 6298 C CA  . LEU B 1 360 ? 71.787 -79.964  -11.718 1.00 78.62  ? 358 LEU B CA  1 
ATOM 6299 C C   . LEU B 1 360 ? 70.316 -79.577  -11.878 1.00 75.11  ? 358 LEU B C   1 
ATOM 6300 O O   . LEU B 1 360 ? 69.985 -78.610  -12.554 1.00 69.96  ? 358 LEU B O   1 
ATOM 6301 C CB  . LEU B 1 360 ? 72.432 -79.122  -10.620 1.00 80.95  ? 358 LEU B CB  1 
ATOM 6302 C CG  . LEU B 1 360 ? 71.747 -79.194  -9.248  1.00 86.95  ? 358 LEU B CG  1 
ATOM 6303 C CD1 . LEU B 1 360 ? 71.848 -80.604  -8.668  1.00 90.71  ? 358 LEU B CD1 1 
ATOM 6304 C CD2 . LEU B 1 360 ? 72.308 -78.187  -8.254  1.00 83.63  ? 358 LEU B CD2 1 
ATOM 6305 N N   . ASN B 1 361 ? 69.455 -80.330  -11.181 1.00 76.69  ? 359 ASN B N   1 
ATOM 6306 C CA  . ASN B 1 361 ? 68.046 -80.018  -11.021 1.00 76.74  ? 359 ASN B CA  1 
ATOM 6307 C C   . ASN B 1 361 ? 67.858 -79.347  -9.661  1.00 77.34  ? 359 ASN B C   1 
ATOM 6308 O O   . ASN B 1 361 ? 68.004 -80.019  -8.638  1.00 83.18  ? 359 ASN B O   1 
ATOM 6309 C CB  . ASN B 1 361 ? 67.205 -81.289  -11.133 1.00 74.39  ? 359 ASN B CB  1 
ATOM 6310 C CG  . ASN B 1 361 ? 65.727 -80.999  -11.286 1.00 71.43  ? 359 ASN B CG  1 
ATOM 6311 O OD1 . ASN B 1 361 ? 65.171 -80.146  -10.578 1.00 63.80  ? 359 ASN B OD1 1 
ATOM 6312 N ND2 . ASN B 1 361 ? 65.065 -81.686  -12.208 1.00 67.20  ? 359 ASN B ND2 1 
ATOM 6313 N N   . VAL B 1 362 ? 67.485 -78.056  -9.654  1.00 70.76  ? 360 VAL B N   1 
ATOM 6314 C CA  . VAL B 1 362 ? 67.418 -77.270  -8.423  1.00 71.35  ? 360 VAL B CA  1 
ATOM 6315 C C   . VAL B 1 362 ? 66.037 -77.342  -7.770  1.00 71.51  ? 360 VAL B C   1 
ATOM 6316 O O   . VAL B 1 362 ? 65.814 -76.730  -6.717  1.00 71.88  ? 360 VAL B O   1 
ATOM 6317 C CB  . VAL B 1 362 ? 67.772 -75.790  -8.632  1.00 69.28  ? 360 VAL B CB  1 
ATOM 6318 C CG1 . VAL B 1 362 ? 69.189 -75.636  -9.151  1.00 72.11  ? 360 VAL B CG1 1 
ATOM 6319 C CG2 . VAL B 1 362 ? 66.748 -75.082  -9.513  1.00 66.92  ? 360 VAL B CG2 1 
ATOM 6320 N N   . MET B 1 363 ? 65.115 -78.059  -8.417  1.00 69.64  ? 361 MET B N   1 
ATOM 6321 C CA  . MET B 1 363 ? 63.746 -78.152  -7.947  1.00 69.70  ? 361 MET B CA  1 
ATOM 6322 C C   . MET B 1 363 ? 63.557 -79.441  -7.140  1.00 69.90  ? 361 MET B C   1 
ATOM 6323 O O   . MET B 1 363 ? 62.432 -79.804  -6.794  1.00 69.18  ? 361 MET B O   1 
ATOM 6324 C CB  . MET B 1 363 ? 62.783 -78.079  -9.139  1.00 66.43  ? 361 MET B CB  1 
ATOM 6325 C CG  . MET B 1 363 ? 63.099 -76.943  -10.111 1.00 65.36  ? 361 MET B CG  1 
ATOM 6326 S SD  . MET B 1 363 ? 62.872 -75.272  -9.466  1.00 55.08  ? 361 MET B SD  1 
ATOM 6327 C CE  . MET B 1 363 ? 63.599 -74.328  -10.805 1.00 52.34  ? 361 MET B CE  1 
ATOM 6328 N N   . GLU B 1 364 ? 64.665 -80.101  -6.780  1.00 71.06  ? 362 GLU B N   1 
ATOM 6329 C CA  . GLU B 1 364 ? 64.586 -81.402  -6.134  1.00 73.53  ? 362 GLU B CA  1 
ATOM 6330 C C   . GLU B 1 364 ? 63.734 -81.310  -4.868  1.00 66.49  ? 362 GLU B C   1 
ATOM 6331 O O   . GLU B 1 364 ? 63.013 -82.253  -4.569  1.00 63.81  ? 362 GLU B O   1 
ATOM 6332 C CB  . GLU B 1 364 ? 65.959 -82.028  -5.848  1.00 86.82  ? 362 GLU B CB  1 
ATOM 6333 C CG  . GLU B 1 364 ? 66.539 -82.818  -7.024  1.00 95.76  ? 362 GLU B CG  1 
ATOM 6334 C CD  . GLU B 1 364 ? 67.548 -83.925  -6.723  1.00 93.59  ? 362 GLU B CD  1 
ATOM 6335 O OE1 . GLU B 1 364 ? 67.706 -84.378  -5.568  1.00 91.70  ? 362 GLU B OE1 1 
ATOM 6336 O OE2 . GLU B 1 364 ? 68.198 -84.353  -7.694  1.00 88.79  ? 362 GLU B OE2 1 
ATOM 6337 N N   . PRO B 1 365 ? 63.772 -80.202  -4.081  1.00 64.29  ? 363 PRO B N   1 
ATOM 6338 C CA  . PRO B 1 365 ? 63.029 -80.137  -2.817  1.00 61.52  ? 363 PRO B CA  1 
ATOM 6339 C C   . PRO B 1 365 ? 61.522 -80.397  -2.899  1.00 66.81  ? 363 PRO B C   1 
ATOM 6340 O O   . PRO B 1 365 ? 61.043 -81.399  -2.360  1.00 76.64  ? 363 PRO B O   1 
ATOM 6341 C CB  . PRO B 1 365 ? 63.352 -78.735  -2.298  1.00 53.66  ? 363 PRO B CB  1 
ATOM 6342 C CG  . PRO B 1 365 ? 64.687 -78.447  -2.894  1.00 53.73  ? 363 PRO B CG  1 
ATOM 6343 C CD  . PRO B 1 365 ? 64.574 -78.989  -4.306  1.00 59.37  ? 363 PRO B CD  1 
ATOM 6344 N N   . VAL B 1 366 ? 60.777 -79.513  -3.583  1.00 60.09  ? 364 VAL B N   1 
ATOM 6345 C CA  . VAL B 1 366 ? 59.333 -79.680  -3.688  1.00 53.81  ? 364 VAL B CA  1 
ATOM 6346 C C   . VAL B 1 366 ? 59.068 -81.086  -4.223  1.00 49.90  ? 364 VAL B C   1 
ATOM 6347 O O   . VAL B 1 366 ? 58.139 -81.761  -3.796  1.00 45.66  ? 364 VAL B O   1 
ATOM 6348 C CB  . VAL B 1 366 ? 58.651 -78.587  -4.542  1.00 50.97  ? 364 VAL B CB  1 
ATOM 6349 C CG1 . VAL B 1 366 ? 59.116 -78.625  -5.991  1.00 52.65  ? 364 VAL B CG1 1 
ATOM 6350 C CG2 . VAL B 1 366 ? 57.124 -78.638  -4.464  1.00 45.31  ? 364 VAL B CG2 1 
ATOM 6351 N N   . LEU B 1 367 ? 59.924 -81.530  -5.144  1.00 52.59  ? 365 LEU B N   1 
ATOM 6352 C CA  . LEU B 1 367 ? 59.810 -82.855  -5.722  1.00 57.57  ? 365 LEU B CA  1 
ATOM 6353 C C   . LEU B 1 367 ? 59.780 -83.900  -4.614  1.00 59.55  ? 365 LEU B C   1 
ATOM 6354 O O   . LEU B 1 367 ? 58.839 -84.688  -4.531  1.00 56.64  ? 365 LEU B O   1 
ATOM 6355 C CB  . LEU B 1 367 ? 60.988 -83.062  -6.670  1.00 57.59  ? 365 LEU B CB  1 
ATOM 6356 C CG  . LEU B 1 367 ? 60.872 -84.228  -7.645  1.00 57.04  ? 365 LEU B CG  1 
ATOM 6357 C CD1 . LEU B 1 367 ? 61.861 -83.934  -8.759  1.00 60.38  ? 365 LEU B CD1 1 
ATOM 6358 C CD2 . LEU B 1 367 ? 61.131 -85.566  -6.994  1.00 56.36  ? 365 LEU B CD2 1 
ATOM 6359 N N   . VAL B 1 368 ? 60.819 -83.875  -3.766  1.00 68.64  ? 366 VAL B N   1 
ATOM 6360 C CA  . VAL B 1 368 ? 61.027 -84.887  -2.737  1.00 74.52  ? 366 VAL B CA  1 
ATOM 6361 C C   . VAL B 1 368 ? 59.929 -84.759  -1.682  1.00 73.20  ? 366 VAL B C   1 
ATOM 6362 O O   . VAL B 1 368 ? 59.445 -85.759  -1.147  1.00 68.61  ? 366 VAL B O   1 
ATOM 6363 C CB  . VAL B 1 368 ? 62.422 -84.783  -2.088  1.00 74.75  ? 366 VAL B CB  1 
ATOM 6364 C CG1 . VAL B 1 368 ? 62.603 -85.833  -0.996  1.00 83.85  ? 366 VAL B CG1 1 
ATOM 6365 C CG2 . VAL B 1 368 ? 63.548 -84.904  -3.108  1.00 73.97  ? 366 VAL B CG2 1 
ATOM 6366 N N   . PHE B 1 369 ? 59.547 -83.514  -1.390  1.00 70.52  ? 367 PHE B N   1 
ATOM 6367 C CA  . PHE B 1 369 ? 58.473 -83.263  -0.449  1.00 72.27  ? 367 PHE B CA  1 
ATOM 6368 C C   . PHE B 1 369 ? 57.233 -84.026  -0.901  1.00 68.34  ? 367 PHE B C   1 
ATOM 6369 O O   . PHE B 1 369 ? 56.663 -84.781  -0.131  1.00 76.35  ? 367 PHE B O   1 
ATOM 6370 C CB  . PHE B 1 369 ? 58.218 -81.760  -0.323  1.00 75.96  ? 367 PHE B CB  1 
ATOM 6371 C CG  . PHE B 1 369 ? 56.972 -81.419  0.477   1.00 70.79  ? 367 PHE B CG  1 
ATOM 6372 C CD1 . PHE B 1 369 ? 56.707 -82.040  1.684   1.00 68.32  ? 367 PHE B CD1 1 
ATOM 6373 C CD2 . PHE B 1 369 ? 56.056 -80.500  -0.002  1.00 77.36  ? 367 PHE B CD2 1 
ATOM 6374 C CE1 . PHE B 1 369 ? 55.557 -81.743  2.393   1.00 73.10  ? 367 PHE B CE1 1 
ATOM 6375 C CE2 . PHE B 1 369 ? 54.910 -80.201  0.714   1.00 81.99  ? 367 PHE B CE2 1 
ATOM 6376 C CZ  . PHE B 1 369 ? 54.657 -80.832  1.907   1.00 76.61  ? 367 PHE B CZ  1 
ATOM 6377 N N   . ASN B 1 370 ? 56.843 -83.848  -2.161  1.00 65.70  ? 368 ASN B N   1 
ATOM 6378 C CA  . ASN B 1 370 ? 55.661 -84.506  -2.680  1.00 65.96  ? 368 ASN B CA  1 
ATOM 6379 C C   . ASN B 1 370 ? 55.890 -86.010  -2.752  1.00 66.47  ? 368 ASN B C   1 
ATOM 6380 O O   . ASN B 1 370 ? 54.984 -86.781  -2.424  1.00 66.82  ? 368 ASN B O   1 
ATOM 6381 C CB  . ASN B 1 370 ? 55.228 -83.925  -4.019  1.00 65.05  ? 368 ASN B CB  1 
ATOM 6382 C CG  . ASN B 1 370 ? 54.611 -82.564  -3.822  1.00 64.63  ? 368 ASN B CG  1 
ATOM 6383 O OD1 . ASN B 1 370 ? 53.390 -82.450  -3.682  1.00 61.35  ? 368 ASN B OD1 1 
ATOM 6384 N ND2 . ASN B 1 370 ? 55.440 -81.538  -3.719  1.00 66.12  ? 368 ASN B ND2 1 
ATOM 6385 N N   . LEU B 1 371 ? 57.092 -86.423  -3.176  1.00 62.99  ? 369 LEU B N   1 
ATOM 6386 C CA  . LEU B 1 371 ? 57.362 -87.844  -3.334  1.00 65.66  ? 369 LEU B CA  1 
ATOM 6387 C C   . LEU B 1 371 ? 57.157 -88.553  -1.991  1.00 66.41  ? 369 LEU B C   1 
ATOM 6388 O O   . LEU B 1 371 ? 56.381 -89.510  -1.877  1.00 55.87  ? 369 LEU B O   1 
ATOM 6389 C CB  . LEU B 1 371 ? 58.749 -88.115  -3.916  1.00 58.27  ? 369 LEU B CB  1 
ATOM 6390 C CG  . LEU B 1 371 ? 59.075 -89.603  -4.129  1.00 60.27  ? 369 LEU B CG  1 
ATOM 6391 C CD1 . LEU B 1 371 ? 57.978 -90.417  -4.823  1.00 56.94  ? 369 LEU B CD1 1 
ATOM 6392 C CD2 . LEU B 1 371 ? 60.364 -89.746  -4.919  1.00 62.78  ? 369 LEU B CD2 1 
ATOM 6393 N N   . LEU B 1 372 ? 57.853 -88.055  -0.966  1.00 65.34  ? 370 LEU B N   1 
ATOM 6394 C CA  . LEU B 1 372 ? 57.840 -88.702  0.331   1.00 61.64  ? 370 LEU B CA  1 
ATOM 6395 C C   . LEU B 1 372 ? 56.427 -88.637  0.899   1.00 59.51  ? 370 LEU B C   1 
ATOM 6396 O O   . LEU B 1 372 ? 55.909 -89.637  1.394   1.00 59.47  ? 370 LEU B O   1 
ATOM 6397 C CB  . LEU B 1 372 ? 58.893 -88.059  1.230   1.00 63.03  ? 370 LEU B CB  1 
ATOM 6398 C CG  . LEU B 1 372 ? 60.346 -88.301  0.801   1.00 61.46  ? 370 LEU B CG  1 
ATOM 6399 C CD1 . LEU B 1 372 ? 61.324 -87.526  1.665   1.00 56.92  ? 370 LEU B CD1 1 
ATOM 6400 C CD2 . LEU B 1 372 ? 60.661 -89.796  0.836   1.00 62.56  ? 370 LEU B CD2 1 
ATOM 6401 N N   . GLN B 1 373 ? 55.787 -87.476  0.752   1.00 55.51  ? 371 GLN B N   1 
ATOM 6402 C CA  . GLN B 1 373 ? 54.416 -87.303  1.204   1.00 49.54  ? 371 GLN B CA  1 
ATOM 6403 C C   . GLN B 1 373 ? 53.509 -88.351  0.583   1.00 52.29  ? 371 GLN B C   1 
ATOM 6404 O O   . GLN B 1 373 ? 52.748 -88.989  1.295   1.00 56.97  ? 371 GLN B O   1 
ATOM 6405 C CB  . GLN B 1 373 ? 53.766 -85.996  0.774   1.00 43.94  ? 371 GLN B CB  1 
ATOM 6406 C CG  . GLN B 1 373 ? 52.280 -85.972  1.074   1.00 41.93  ? 371 GLN B CG  1 
ATOM 6407 C CD  . GLN B 1 373 ? 51.683 -84.598  0.955   1.00 47.54  ? 371 GLN B CD  1 
ATOM 6408 O OE1 . GLN B 1 373 ? 50.862 -84.307  0.073   1.00 55.77  ? 371 GLN B OE1 1 
ATOM 6409 N NE2 . GLN B 1 373 ? 52.105 -83.743  1.871   1.00 53.43  ? 371 GLN B NE2 1 
ATOM 6410 N N   . SER B 1 374 ? 53.571 -88.467  -0.749  1.00 52.16  ? 372 SER B N   1 
ATOM 6411 C CA  . SER B 1 374 ? 52.750 -89.423  -1.468  1.00 60.20  ? 372 SER B CA  1 
ATOM 6412 C C   . SER B 1 374 ? 52.881 -90.808  -0.816  1.00 65.25  ? 372 SER B C   1 
ATOM 6413 O O   . SER B 1 374 ? 51.879 -91.431  -0.467  1.00 72.36  ? 372 SER B O   1 
ATOM 6414 C CB  . SER B 1 374 ? 53.084 -89.450  -2.956  1.00 60.50  ? 372 SER B CB  1 
ATOM 6415 O OG  . SER B 1 374 ? 52.461 -88.407  -3.695  1.00 59.12  ? 372 SER B OG  1 
ATOM 6416 N N   . ILE B 1 375 ? 54.122 -91.272  -0.603  1.00 56.72  ? 373 ILE B N   1 
ATOM 6417 C CA  . ILE B 1 375 ? 54.350 -92.628  -0.130  1.00 54.67  ? 373 ILE B CA  1 
ATOM 6418 C C   . ILE B 1 375 ? 53.754 -92.797  1.266   1.00 56.56  ? 373 ILE B C   1 
ATOM 6419 O O   . ILE B 1 375 ? 53.135 -93.819  1.566   1.00 55.43  ? 373 ILE B O   1 
ATOM 6420 C CB  . ILE B 1 375 ? 55.847 -92.990  -0.136  1.00 54.97  ? 373 ILE B CB  1 
ATOM 6421 C CG1 . ILE B 1 375 ? 56.495 -92.793  -1.516  1.00 58.08  ? 373 ILE B CG1 1 
ATOM 6422 C CG2 . ILE B 1 375 ? 56.042 -94.421  0.367   1.00 51.79  ? 373 ILE B CG2 1 
ATOM 6423 C CD1 . ILE B 1 375 ? 58.008 -92.639  -1.498  1.00 61.42  ? 373 ILE B CD1 1 
ATOM 6424 N N   . SER B 1 376 ? 53.995 -91.808  2.127   1.00 57.00  ? 374 SER B N   1 
ATOM 6425 C CA  . SER B 1 376 ? 53.535 -91.882  3.501   1.00 57.31  ? 374 SER B CA  1 
ATOM 6426 C C   . SER B 1 376 ? 52.013 -91.919  3.537   1.00 61.15  ? 374 SER B C   1 
ATOM 6427 O O   . SER B 1 376 ? 51.432 -92.755  4.220   1.00 70.53  ? 374 SER B O   1 
ATOM 6428 C CB  . SER B 1 376 ? 54.063 -90.735  4.303   1.00 60.79  ? 374 SER B CB  1 
ATOM 6429 O OG  . SER B 1 376 ? 55.409 -90.480  3.940   1.00 71.37  ? 374 SER B OG  1 
ATOM 6430 N N   . ILE B 1 377 ? 51.378 -90.985  2.828   1.00 65.30  ? 375 ILE B N   1 
ATOM 6431 C CA  . ILE B 1 377 ? 49.933 -90.848  2.858   1.00 64.23  ? 375 ILE B CA  1 
ATOM 6432 C C   . ILE B 1 377 ? 49.290 -92.186  2.495   1.00 68.10  ? 375 ILE B C   1 
ATOM 6433 O O   . ILE B 1 377 ? 48.350 -92.635  3.147   1.00 70.92  ? 375 ILE B O   1 
ATOM 6434 C CB  . ILE B 1 377 ? 49.506 -89.732  1.892   1.00 71.10  ? 375 ILE B CB  1 
ATOM 6435 C CG1 . ILE B 1 377 ? 49.764 -88.369  2.454   1.00 76.00  ? 375 ILE B CG1 1 
ATOM 6436 C CG2 . ILE B 1 377 ? 48.047 -89.871  1.505   1.00 84.49  ? 375 ILE B CG2 1 
ATOM 6437 C CD1 . ILE B 1 377 ? 49.114 -87.269  1.629   1.00 85.98  ? 375 ILE B CD1 1 
ATOM 6438 N N   . MET B 1 378 ? 49.788 -92.813  1.423   1.00 77.08  ? 376 MET B N   1 
ATOM 6439 C CA  . MET B 1 378 ? 49.242 -94.072  0.942   1.00 78.31  ? 376 MET B CA  1 
ATOM 6440 C C   . MET B 1 378 ? 49.393 -95.155  2.010   1.00 72.53  ? 376 MET B C   1 
ATOM 6441 O O   . MET B 1 378 ? 48.437 -95.877  2.298   1.00 68.35  ? 376 MET B O   1 
ATOM 6442 C CB  . MET B 1 378 ? 49.954 -94.519  -0.339  1.00 81.50  ? 376 MET B CB  1 
ATOM 6443 C CG  . MET B 1 378 ? 49.694 -93.624  -1.531  1.00 78.44  ? 376 MET B CG  1 
ATOM 6444 S SD  . MET B 1 378 ? 50.758 -94.029  -2.928  1.00 73.39  ? 376 MET B SD  1 
ATOM 6445 C CE  . MET B 1 378 ? 50.275 -95.720  -3.284  1.00 63.94  ? 376 MET B CE  1 
ATOM 6446 N N   . ASN B 1 379 ? 50.588 -95.244  2.609   1.00 67.34  ? 377 ASN B N   1 
ATOM 6447 C CA  . ASN B 1 379 ? 50.869 -96.263  3.607   1.00 66.00  ? 377 ASN B CA  1 
ATOM 6448 C C   . ASN B 1 379 ? 49.863 -96.153  4.754   1.00 62.26  ? 377 ASN B C   1 
ATOM 6449 O O   . ASN B 1 379 ? 49.332 -97.153  5.239   1.00 59.69  ? 377 ASN B O   1 
ATOM 6450 C CB  . ASN B 1 379 ? 52.295 -96.135  4.119   1.00 64.20  ? 377 ASN B CB  1 
ATOM 6451 C CG  . ASN B 1 379 ? 52.643 -97.197  5.124   1.00 66.75  ? 377 ASN B CG  1 
ATOM 6452 O OD1 . ASN B 1 379 ? 52.723 -96.889  6.309   1.00 77.50  ? 377 ASN B OD1 1 
ATOM 6453 N ND2 . ASN B 1 379 ? 52.861 -98.430  4.690   1.00 71.83  ? 377 ASN B ND2 1 
ATOM 6454 N N   . ASN B 1 380 ? 49.597 -94.912  5.167   1.00 58.84  ? 378 ASN B N   1 
ATOM 6455 C CA  . ASN B 1 380 ? 48.656 -94.633  6.235   1.00 59.86  ? 378 ASN B CA  1 
ATOM 6456 C C   . ASN B 1 380 ? 47.239 -94.964  5.789   1.00 54.14  ? 378 ASN B C   1 
ATOM 6457 O O   . ASN B 1 380 ? 46.534 -95.721  6.445   1.00 52.20  ? 378 ASN B O   1 
ATOM 6458 C CB  . ASN B 1 380 ? 48.752 -93.180  6.678   1.00 64.08  ? 378 ASN B CB  1 
ATOM 6459 C CG  . ASN B 1 380 ? 50.160 -92.802  7.073   1.00 70.26  ? 378 ASN B CG  1 
ATOM 6460 O OD1 . ASN B 1 380 ? 51.079 -93.635  7.074   1.00 75.44  ? 378 ASN B OD1 1 
ATOM 6461 N ND2 . ASN B 1 380 ? 50.343 -91.540  7.406   1.00 76.82  ? 378 ASN B ND2 1 
ATOM 6462 N N   . GLY B 1 381 ? 46.847 -94.410  4.650   1.00 57.30  ? 379 GLY B N   1 
ATOM 6463 C CA  . GLY B 1 381 ? 45.516 -94.653  4.133   1.00 64.19  ? 379 GLY B CA  1 
ATOM 6464 C C   . GLY B 1 381 ? 45.222 -96.149  4.028   1.00 66.09  ? 379 GLY B C   1 
ATOM 6465 O O   . GLY B 1 381 ? 44.126 -96.598  4.373   1.00 58.87  ? 379 GLY B O   1 
ATOM 6466 N N   . PHE B 1 382 ? 46.206 -96.906  3.526   1.00 66.26  ? 380 PHE B N   1 
ATOM 6467 C CA  . PHE B 1 382 ? 46.011 -98.318  3.256   1.00 75.39  ? 380 PHE B CA  1 
ATOM 6468 C C   . PHE B 1 382 ? 45.888 -99.087  4.566   1.00 82.97  ? 380 PHE B C   1 
ATOM 6469 O O   . PHE B 1 382 ? 45.081 -100.011 4.670   1.00 80.00  ? 380 PHE B O   1 
ATOM 6470 C CB  . PHE B 1 382 ? 47.174 -98.881  2.435   1.00 79.33  ? 380 PHE B CB  1 
ATOM 6471 C CG  . PHE B 1 382 ? 47.258 -98.443  0.979   1.00 74.82  ? 380 PHE B CG  1 
ATOM 6472 C CD1 . PHE B 1 382 ? 46.152 -97.919  0.317   1.00 74.13  ? 380 PHE B CD1 1 
ATOM 6473 C CD2 . PHE B 1 382 ? 48.448 -98.589  0.265   1.00 69.41  ? 380 PHE B CD2 1 
ATOM 6474 C CE1 . PHE B 1 382 ? 46.244 -97.533  -1.011  1.00 73.81  ? 380 PHE B CE1 1 
ATOM 6475 C CE2 . PHE B 1 382 ? 48.533 -98.210  -1.064  1.00 66.13  ? 380 PHE B CE2 1 
ATOM 6476 C CZ  . PHE B 1 382 ? 47.434 -97.677  -1.696  1.00 71.46  ? 380 PHE B CZ  1 
ATOM 6477 N N   . ARG B 1 383 ? 46.713 -98.718  5.551   1.00 83.35  ? 381 ARG B N   1 
ATOM 6478 C CA  . ARG B 1 383 ? 46.709 -99.413  6.824   1.00 82.06  ? 381 ARG B CA  1 
ATOM 6479 C C   . ARG B 1 383 ? 45.310 -99.309  7.443   1.00 66.62  ? 381 ARG B C   1 
ATOM 6480 O O   . ARG B 1 383 ? 44.693 -100.322 7.774   1.00 64.54  ? 381 ARG B O   1 
ATOM 6481 C CB  . ARG B 1 383 ? 47.867 -98.885  7.679   1.00 92.90  ? 381 ARG B CB  1 
ATOM 6482 C CG  . ARG B 1 383 ? 48.041 -99.628  8.992   1.00 116.28 ? 381 ARG B CG  1 
ATOM 6483 C CD  . ARG B 1 383 ? 49.206 -99.110  9.823   1.00 133.19 ? 381 ARG B CD  1 
ATOM 6484 N NE  . ARG B 1 383 ? 49.193 -99.775  11.132  1.00 143.59 ? 381 ARG B NE  1 
ATOM 6485 C CZ  . ARG B 1 383 ? 50.175 -99.763  12.020  1.00 137.39 ? 381 ARG B CZ  1 
ATOM 6486 N NH1 . ARG B 1 383 ? 51.258 -99.038  11.813  1.00 136.62 ? 381 ARG B NH1 1 
ATOM 6487 N NH2 . ARG B 1 383 ? 50.067 -100.477 13.127  1.00 144.88 ? 381 ARG B NH2 1 
ATOM 6488 N N   . VAL B 1 384 ? 44.787 -98.081  7.532   1.00 60.76  ? 382 VAL B N   1 
ATOM 6489 C CA  . VAL B 1 384 ? 43.505 -97.812  8.181   1.00 57.95  ? 382 VAL B CA  1 
ATOM 6490 C C   . VAL B 1 384 ? 42.382 -98.440  7.367   1.00 58.77  ? 382 VAL B C   1 
ATOM 6491 O O   . VAL B 1 384 ? 41.368 -98.835  7.925   1.00 55.46  ? 382 VAL B O   1 
ATOM 6492 C CB  . VAL B 1 384 ? 43.121 -96.331  8.392   1.00 59.32  ? 382 VAL B CB  1 
ATOM 6493 C CG1 . VAL B 1 384 ? 43.953 -95.622  9.449   1.00 58.17  ? 382 VAL B CG1 1 
ATOM 6494 C CG2 . VAL B 1 384 ? 43.137 -95.547  7.084   1.00 62.04  ? 382 VAL B CG2 1 
ATOM 6495 N N   . PHE B 1 385 ? 42.542 -98.443  6.041   1.00 64.79  ? 383 PHE B N   1 
ATOM 6496 C CA  . PHE B 1 385 ? 41.500 -98.893  5.139   1.00 72.69  ? 383 PHE B CA  1 
ATOM 6497 C C   . PHE B 1 385 ? 41.446 -100.416 5.178   1.00 78.48  ? 383 PHE B C   1 
ATOM 6498 O O   . PHE B 1 385 ? 40.364 -101.008 5.124   1.00 79.57  ? 383 PHE B O   1 
ATOM 6499 C CB  . PHE B 1 385 ? 41.789 -98.285  3.761   1.00 76.51  ? 383 PHE B CB  1 
ATOM 6500 C CG  . PHE B 1 385 ? 40.948 -98.801  2.599   1.00 75.07  ? 383 PHE B CG  1 
ATOM 6501 C CD1 . PHE B 1 385 ? 39.632 -98.379  2.422   1.00 71.20  ? 383 PHE B CD1 1 
ATOM 6502 C CD2 . PHE B 1 385 ? 41.499 -99.669  1.659   1.00 66.36  ? 383 PHE B CD2 1 
ATOM 6503 C CE1 . PHE B 1 385 ? 38.882 -98.848  1.358   1.00 70.19  ? 383 PHE B CE1 1 
ATOM 6504 C CE2 . PHE B 1 385 ? 40.747 -100.124 0.593   1.00 65.53  ? 383 PHE B CE2 1 
ATOM 6505 C CZ  . PHE B 1 385 ? 39.439 -99.718  0.447   1.00 69.41  ? 383 PHE B CZ  1 
ATOM 6506 N N   . THR B 1 386 ? 42.624 -101.041 5.283   1.00 76.84  ? 384 THR B N   1 
ATOM 6507 C CA  . THR B 1 386 ? 42.675 -102.485 5.419   1.00 82.84  ? 384 THR B CA  1 
ATOM 6508 C C   . THR B 1 386 ? 41.884 -102.868 6.670   1.00 79.70  ? 384 THR B C   1 
ATOM 6509 O O   . THR B 1 386 ? 40.914 -103.607 6.557   1.00 82.89  ? 384 THR B O   1 
ATOM 6510 C CB  . THR B 1 386 ? 44.118 -102.999 5.452   1.00 85.32  ? 384 THR B CB  1 
ATOM 6511 O OG1 . THR B 1 386 ? 44.853 -102.501 4.336   1.00 75.97  ? 384 THR B OG1 1 
ATOM 6512 C CG2 . THR B 1 386 ? 44.186 -104.511 5.346   1.00 88.63  ? 384 THR B CG2 1 
ATOM 6513 N N   . GLU B 1 387 ? 42.234 -102.303 7.832   1.00 73.60  ? 385 GLU B N   1 
ATOM 6514 C CA  . GLU B 1 387 ? 41.639 -102.739 9.093   1.00 79.07  ? 385 GLU B CA  1 
ATOM 6515 C C   . GLU B 1 387 ? 40.211 -102.219 9.284   1.00 75.22  ? 385 GLU B C   1 
ATOM 6516 O O   . GLU B 1 387 ? 39.284 -102.985 9.517   1.00 75.91  ? 385 GLU B O   1 
ATOM 6517 C CB  . GLU B 1 387 ? 42.485 -102.326 10.296  1.00 82.62  ? 385 GLU B CB  1 
ATOM 6518 C CG  . GLU B 1 387 ? 43.963 -102.652 10.135  1.00 92.72  ? 385 GLU B CG  1 
ATOM 6519 C CD  . GLU B 1 387 ? 44.210 -104.133 9.929   1.00 98.06  ? 385 GLU B CD  1 
ATOM 6520 O OE1 . GLU B 1 387 ? 43.756 -104.904 10.807  1.00 89.04  ? 385 GLU B OE1 1 
ATOM 6521 O OE2 . GLU B 1 387 ? 44.857 -104.498 8.914   1.00 105.23 ? 385 GLU B OE2 1 
ATOM 6522 N N   . TYR B 1 388 ? 40.015 -100.903 9.209   1.00 79.10  ? 386 TYR B N   1 
ATOM 6523 C CA  . TYR B 1 388 ? 38.775 -100.285 9.662   1.00 78.39  ? 386 TYR B CA  1 
ATOM 6524 C C   . TYR B 1 388 ? 37.623 -100.559 8.702   1.00 71.27  ? 386 TYR B C   1 
ATOM 6525 O O   . TYR B 1 388 ? 36.509 -100.695 9.173   1.00 84.88  ? 386 TYR B O   1 
ATOM 6526 C CB  . TYR B 1 388 ? 38.998 -98.790  9.908   1.00 81.69  ? 386 TYR B CB  1 
ATOM 6527 C CG  . TYR B 1 388 ? 40.068 -98.488  10.955  1.00 81.05  ? 386 TYR B CG  1 
ATOM 6528 C CD1 . TYR B 1 388 ? 40.449 -99.438  11.904  1.00 69.35  ? 386 TYR B CD1 1 
ATOM 6529 C CD2 . TYR B 1 388 ? 40.686 -97.241  11.009  1.00 87.75  ? 386 TYR B CD2 1 
ATOM 6530 C CE1 . TYR B 1 388 ? 41.425 -99.171  12.851  1.00 67.08  ? 386 TYR B CE1 1 
ATOM 6531 C CE2 . TYR B 1 388 ? 41.659 -96.960  11.957  1.00 78.41  ? 386 TYR B CE2 1 
ATOM 6532 C CZ  . TYR B 1 388 ? 42.023 -97.926  12.878  1.00 70.78  ? 386 TYR B CZ  1 
ATOM 6533 O OH  . TYR B 1 388 ? 43.001 -97.646  13.776  1.00 69.31  ? 386 TYR B OH  1 
ATOM 6534 N N   . CYS B 1 389 ? 37.873 -100.722 7.399   1.00 69.84  ? 387 CYS B N   1 
ATOM 6535 C CA  . CYS B 1 389 ? 36.783 -100.953 6.455   1.00 82.89  ? 387 CYS B CA  1 
ATOM 6536 C C   . CYS B 1 389 ? 36.868 -102.344 5.816   1.00 81.62  ? 387 CYS B C   1 
ATOM 6537 O O   . CYS B 1 389 ? 35.988 -103.175 6.010   1.00 84.31  ? 387 CYS B O   1 
ATOM 6538 C CB  . CYS B 1 389 ? 36.763 -99.881  5.369   1.00 84.51  ? 387 CYS B CB  1 
ATOM 6539 S SG  . CYS B 1 389 ? 35.623 -100.197 4.004   1.00 79.83  ? 387 CYS B SG  1 
ATOM 6540 N N   . VAL B 1 390 ? 37.902 -102.573 5.009   1.00 72.73  ? 388 VAL B N   1 
ATOM 6541 C CA  . VAL B 1 390 ? 37.981 -103.754 4.152   1.00 79.56  ? 388 VAL B CA  1 
ATOM 6542 C C   . VAL B 1 390 ? 37.690 -105.064 4.892   1.00 80.80  ? 388 VAL B C   1 
ATOM 6543 O O   . VAL B 1 390 ? 36.874 -105.865 4.439   1.00 88.92  ? 388 VAL B O   1 
ATOM 6544 C CB  . VAL B 1 390 ? 39.340 -103.870 3.434   1.00 85.47  ? 388 VAL B CB  1 
ATOM 6545 C CG1 . VAL B 1 390 ? 39.527 -105.223 2.746   1.00 77.39  ? 388 VAL B CG1 1 
ATOM 6546 C CG2 . VAL B 1 390 ? 39.501 -102.765 2.410   1.00 94.31  ? 388 VAL B CG2 1 
ATOM 6547 N N   . LYS B 1 391 ? 38.434 -105.360 5.957   1.00 72.63  ? 389 LYS B N   1 
ATOM 6548 C CA  . LYS B 1 391 ? 38.277 -106.631 6.639   1.00 66.63  ? 389 LYS B CA  1 
ATOM 6549 C C   . LYS B 1 391 ? 36.857 -106.785 7.179   1.00 72.82  ? 389 LYS B C   1 
ATOM 6550 O O   . LYS B 1 391 ? 36.388 -107.902 7.365   1.00 82.64  ? 389 LYS B O   1 
ATOM 6551 C CB  . LYS B 1 391 ? 39.288 -106.727 7.779   1.00 70.84  ? 389 LYS B CB  1 
ATOM 6552 C CG  . LYS B 1 391 ? 40.728 -106.845 7.325   1.00 84.93  ? 389 LYS B CG  1 
ATOM 6553 C CD  . LYS B 1 391 ? 41.701 -106.929 8.497   1.00 90.46  ? 389 LYS B CD  1 
ATOM 6554 C CE  . LYS B 1 391 ? 43.074 -107.299 8.062   1.00 97.52  ? 389 LYS B CE  1 
ATOM 6555 N NZ  . LYS B 1 391 ? 43.949 -107.419 9.224   1.00 102.42 ? 389 LYS B NZ  1 
ATOM 6556 N N   . GLY B 1 392 ? 36.164 -105.676 7.451   1.00 77.03  ? 390 GLY B N   1 
ATOM 6557 C CA  . GLY B 1 392 ? 34.858 -105.741 8.083   1.00 73.04  ? 390 GLY B CA  1 
ATOM 6558 C C   . GLY B 1 392 ? 33.703 -105.730 7.088   1.00 73.27  ? 390 GLY B C   1 
ATOM 6559 O O   . GLY B 1 392 ? 32.549 -105.749 7.507   1.00 79.71  ? 390 GLY B O   1 
ATOM 6560 N N   . ILE B 1 393 ? 33.990 -105.743 5.780   1.00 76.34  ? 391 ILE B N   1 
ATOM 6561 C CA  . ILE B 1 393 ? 32.919 -105.621 4.798   1.00 78.22  ? 391 ILE B CA  1 
ATOM 6562 C C   . ILE B 1 393 ? 32.015 -106.846 4.897   1.00 76.65  ? 391 ILE B C   1 
ATOM 6563 O O   . ILE B 1 393 ? 32.519 -107.950 5.061   1.00 73.60  ? 391 ILE B O   1 
ATOM 6564 C CB  . ILE B 1 393 ? 33.475 -105.447 3.378   1.00 82.44  ? 391 ILE B CB  1 
ATOM 6565 C CG1 . ILE B 1 393 ? 34.366 -104.219 3.279   1.00 86.91  ? 391 ILE B CG1 1 
ATOM 6566 C CG2 . ILE B 1 393 ? 32.339 -105.395 2.356   1.00 89.03  ? 391 ILE B CG2 1 
ATOM 6567 C CD1 . ILE B 1 393 ? 34.998 -104.022 1.911   1.00 95.80  ? 391 ILE B CD1 1 
ATOM 6568 N N   . GLU B 1 394 ? 30.692 -106.633 4.827   1.00 77.77  ? 392 GLU B N   1 
ATOM 6569 C CA  . GLU B 1 394 ? 29.720 -107.714 4.937   1.00 81.59  ? 392 GLU B CA  1 
ATOM 6570 C C   . GLU B 1 394 ? 28.755 -107.601 3.764   1.00 76.89  ? 392 GLU B C   1 
ATOM 6571 O O   . GLU B 1 394 ? 28.541 -106.494 3.272   1.00 86.78  ? 392 GLU B O   1 
ATOM 6572 C CB  . GLU B 1 394 ? 28.984 -107.564 6.272   1.00 90.40  ? 392 GLU B CB  1 
ATOM 6573 C CG  . GLU B 1 394 ? 28.255 -108.808 6.766   1.00 96.50  ? 392 GLU B CG  1 
ATOM 6574 C CD  . GLU B 1 394 ? 29.190 -109.772 7.462   1.00 106.54 ? 392 GLU B CD  1 
ATOM 6575 O OE1 . GLU B 1 394 ? 30.410 -109.478 7.576   1.00 102.83 ? 392 GLU B OE1 1 
ATOM 6576 O OE2 . GLU B 1 394 ? 28.677 -110.828 7.893   1.00 119.56 ? 392 GLU B OE2 1 
ATOM 6577 N N   . ALA B 1 395 ? 28.163 -108.727 3.343   1.00 67.58  ? 393 ALA B N   1 
ATOM 6578 C CA  . ALA B 1 395 ? 27.327 -108.744 2.145   1.00 66.06  ? 393 ALA B CA  1 
ATOM 6579 C C   . ALA B 1 395 ? 25.836 -108.832 2.472   1.00 64.84  ? 393 ALA B C   1 
ATOM 6580 O O   . ALA B 1 395 ? 25.481 -109.360 3.513   1.00 83.31  ? 393 ALA B O   1 
ATOM 6581 C CB  . ALA B 1 395 ? 27.743 -109.906 1.291   1.00 66.41  ? 393 ALA B CB  1 
ATOM 6582 N N   . ASN B 1 396 ? 24.975 -108.338 1.573   1.00 65.32  ? 394 ASN B N   1 
ATOM 6583 C CA  . ASN B 1 396 ? 23.531 -108.485 1.712   1.00 75.17  ? 394 ASN B CA  1 
ATOM 6584 C C   . ASN B 1 396 ? 23.000 -109.476 0.683   1.00 90.06  ? 394 ASN B C   1 
ATOM 6585 O O   . ASN B 1 396 ? 22.215 -109.077 -0.178  1.00 102.61 ? 394 ASN B O   1 
ATOM 6586 C CB  . ASN B 1 396 ? 22.781 -107.176 1.491   1.00 74.58  ? 394 ASN B CB  1 
ATOM 6587 C CG  . ASN B 1 396 ? 23.150 -106.140 2.520   1.00 81.62  ? 394 ASN B CG  1 
ATOM 6588 O OD1 . ASN B 1 396 ? 23.643 -106.494 3.598   1.00 76.01  ? 394 ASN B OD1 1 
ATOM 6589 N ND2 . ASN B 1 396 ? 22.896 -104.876 2.206   1.00 87.78  ? 394 ASN B ND2 1 
ATOM 6590 N N   . GLU B 1 397 ? 23.407 -110.754 0.776   1.00 97.86  ? 395 GLU B N   1 
ATOM 6591 C CA  . GLU B 1 397 ? 23.152 -111.733 -0.287  1.00 91.10  ? 395 GLU B CA  1 
ATOM 6592 C C   . GLU B 1 397 ? 21.683 -111.761 -0.718  1.00 86.10  ? 395 GLU B C   1 
ATOM 6593 O O   . GLU B 1 397 ? 21.383 -111.851 -1.911  1.00 81.79  ? 395 GLU B O   1 
ATOM 6594 C CB  . GLU B 1 397 ? 23.612 -113.150 0.041   1.00 92.41  ? 395 GLU B CB  1 
ATOM 6595 C CG  . GLU B 1 397 ? 22.910 -113.777 1.240   1.00 106.93 ? 395 GLU B CG  1 
ATOM 6596 C CD  . GLU B 1 397 ? 23.377 -115.199 1.481   1.00 109.67 ? 395 GLU B CD  1 
ATOM 6597 O OE1 . GLU B 1 397 ? 23.874 -115.477 2.594   1.00 115.16 ? 395 GLU B OE1 1 
ATOM 6598 O OE2 . GLU B 1 397 ? 23.270 -116.027 0.547   1.00 99.11  ? 395 GLU B OE2 1 
ATOM 6599 N N   . GLU B 1 398 ? 20.766 -111.615 0.241   1.00 88.76  ? 396 GLU B N   1 
ATOM 6600 C CA  . GLU B 1 398 ? 19.347 -111.668 -0.087  1.00 98.22  ? 396 GLU B CA  1 
ATOM 6601 C C   . GLU B 1 398 ? 18.964 -110.502 -1.010  1.00 93.80  ? 396 GLU B C   1 
ATOM 6602 O O   . GLU B 1 398 ? 18.133 -110.657 -1.903  1.00 102.66 ? 396 GLU B O   1 
ATOM 6603 C CB  . GLU B 1 398 ? 18.488 -111.730 1.177   1.00 106.14 ? 396 GLU B CB  1 
ATOM 6604 C CG  . GLU B 1 398 ? 18.570 -113.069 1.912   1.00 114.46 ? 396 GLU B CG  1 
ATOM 6605 C CD  . GLU B 1 398 ? 18.198 -114.316 1.113   1.00 111.40 ? 396 GLU B CD  1 
ATOM 6606 O OE1 . GLU B 1 398 ? 17.100 -114.337 0.521   1.00 109.93 ? 396 GLU B OE1 1 
ATOM 6607 O OE2 . GLU B 1 398 ? 18.995 -115.281 1.090   1.00 100.01 ? 396 GLU B OE2 1 
ATOM 6608 N N   . LYS B 1 399 ? 19.587 -109.336 -0.805  1.00 90.31  ? 397 LYS B N   1 
ATOM 6609 C CA  . LYS B 1 399 ? 19.357 -108.197 -1.674  1.00 79.59  ? 397 LYS B CA  1 
ATOM 6610 C C   . LYS B 1 399 ? 19.982 -108.463 -3.039  1.00 80.76  ? 397 LYS B C   1 
ATOM 6611 O O   . LYS B 1 399 ? 19.399 -108.099 -4.054  1.00 80.78  ? 397 LYS B O   1 
ATOM 6612 C CB  . LYS B 1 399 ? 19.891 -106.879 -1.102  1.00 74.30  ? 397 LYS B CB  1 
ATOM 6613 C CG  . LYS B 1 399 ? 19.337 -105.645 -1.819  1.00 72.55  ? 397 LYS B CG  1 
ATOM 6614 C CD  . LYS B 1 399 ? 17.811 -105.550 -1.865  1.00 75.58  ? 397 LYS B CD  1 
ATOM 6615 C CE  . LYS B 1 399 ? 17.266 -104.421 -2.687  1.00 80.57  ? 397 LYS B CE  1 
ATOM 6616 N NZ  . LYS B 1 399 ? 17.726 -103.075 -2.321  1.00 86.78  ? 397 LYS B NZ  1 
ATOM 6617 N N   . MET B 1 400 ? 21.166 -109.093 -3.049  1.00 87.45  ? 398 MET B N   1 
ATOM 6618 C CA  . MET B 1 400 ? 21.919 -109.358 -4.269  1.00 89.56  ? 398 MET B CA  1 
ATOM 6619 C C   . MET B 1 400 ? 21.243 -110.454 -5.099  1.00 90.48  ? 398 MET B C   1 
ATOM 6620 O O   . MET B 1 400 ? 21.196 -110.341 -6.319  1.00 94.55  ? 398 MET B O   1 
ATOM 6621 C CB  . MET B 1 400 ? 23.360 -109.803 -3.969  1.00 93.12  ? 398 MET B CB  1 
ATOM 6622 C CG  . MET B 1 400 ? 24.348 -108.698 -3.609  1.00 88.37  ? 398 MET B CG  1 
ATOM 6623 S SD  . MET B 1 400 ? 26.050 -109.320 -3.493  1.00 84.53  ? 398 MET B SD  1 
ATOM 6624 C CE  . MET B 1 400 ? 25.991 -110.286 -1.982  1.00 94.20  ? 398 MET B CE  1 
ATOM 6625 N N   . LYS B 1 401 ? 20.745 -111.515 -4.448  1.00 88.36  ? 399 LYS B N   1 
ATOM 6626 C CA  . LYS B 1 401 ? 20.012 -112.573 -5.129  1.00 92.27  ? 399 LYS B CA  1 
ATOM 6627 C C   . LYS B 1 401 ? 18.728 -112.014 -5.741  1.00 90.43  ? 399 LYS B C   1 
ATOM 6628 O O   . LYS B 1 401 ? 18.391 -112.364 -6.872  1.00 101.29 ? 399 LYS B O   1 
ATOM 6629 C CB  . LYS B 1 401 ? 19.662 -113.735 -4.192  1.00 103.22 ? 399 LYS B CB  1 
ATOM 6630 C CG  . LYS B 1 401 ? 19.159 -115.005 -4.904  1.00 116.66 ? 399 LYS B CG  1 
ATOM 6631 C CD  . LYS B 1 401 ? 18.580 -116.095 -4.009  1.00 128.78 ? 399 LYS B CD  1 
ATOM 6632 C CE  . LYS B 1 401 ? 19.547 -116.644 -3.005  1.00 140.01 ? 399 LYS B CE  1 
ATOM 6633 N NZ  . LYS B 1 401 ? 18.888 -117.496 -2.011  1.00 145.86 ? 399 LYS B NZ  1 
ATOM 6634 N N   . GLU B 1 402 ? 18.035 -111.137 -4.998  1.00 81.88  ? 400 GLU B N   1 
ATOM 6635 C CA  . GLU B 1 402 ? 16.810 -110.506 -5.473  1.00 81.97  ? 400 GLU B CA  1 
ATOM 6636 C C   . GLU B 1 402 ? 17.030 -109.795 -6.811  1.00 86.92  ? 400 GLU B C   1 
ATOM 6637 O O   . GLU B 1 402 ? 16.178 -109.870 -7.693  1.00 85.10  ? 400 GLU B O   1 
ATOM 6638 C CB  . GLU B 1 402 ? 16.275 -109.481 -4.472  1.00 94.26  ? 400 GLU B CB  1 
ATOM 6639 C CG  . GLU B 1 402 ? 14.912 -108.896 -4.847  1.00 106.05 ? 400 GLU B CG  1 
ATOM 6640 C CD  . GLU B 1 402 ? 14.626 -107.528 -4.255  1.00 107.37 ? 400 GLU B CD  1 
ATOM 6641 O OE1 . GLU B 1 402 ? 14.629 -107.469 -3.005  1.00 110.39 ? 400 GLU B OE1 1 
ATOM 6642 O OE2 . GLU B 1 402 ? 14.419 -106.546 -5.019  1.00 101.09 ? 400 GLU B OE2 1 
ATOM 6643 N N   . TYR B 1 403 ? 18.150 -109.069 -6.943  1.00 98.40  ? 401 TYR B N   1 
ATOM 6644 C CA  . TYR B 1 403 ? 18.471 -108.354 -8.173  1.00 96.34  ? 401 TYR B CA  1 
ATOM 6645 C C   . TYR B 1 403 ? 18.573 -109.327 -9.347  1.00 97.33  ? 401 TYR B C   1 
ATOM 6646 O O   . TYR B 1 403 ? 18.123 -108.991 -10.442 1.00 104.96 ? 401 TYR B O   1 
ATOM 6647 C CB  . TYR B 1 403 ? 19.759 -107.519 -8.079  1.00 91.60  ? 401 TYR B CB  1 
ATOM 6648 C CG  . TYR B 1 403 ? 19.649 -106.211 -7.301  1.00 87.44  ? 401 TYR B CG  1 
ATOM 6649 C CD1 . TYR B 1 403 ? 18.468 -105.468 -7.290  1.00 86.83  ? 401 TYR B CD1 1 
ATOM 6650 C CD2 . TYR B 1 403 ? 20.728 -105.712 -6.578  1.00 82.06  ? 401 TYR B CD2 1 
ATOM 6651 C CE1 . TYR B 1 403 ? 18.362 -104.281 -6.582  1.00 88.08  ? 401 TYR B CE1 1 
ATOM 6652 C CE2 . TYR B 1 403 ? 20.630 -104.528 -5.861  1.00 86.68  ? 401 TYR B CE2 1 
ATOM 6653 C CZ  . TYR B 1 403 ? 19.446 -103.802 -5.868  1.00 86.30  ? 401 TYR B CZ  1 
ATOM 6654 O OH  . TYR B 1 403 ? 19.314 -102.640 -5.146  1.00 69.27  ? 401 TYR B OH  1 
ATOM 6655 N N   . VAL B 1 404 ? 19.165 -110.513 -9.121  1.00 85.16  ? 402 VAL B N   1 
ATOM 6656 C CA  . VAL B 1 404 ? 19.325 -111.499 -10.179 1.00 83.58  ? 402 VAL B CA  1 
ATOM 6657 C C   . VAL B 1 404 ? 17.940 -111.928 -10.646 1.00 86.68  ? 402 VAL B C   1 
ATOM 6658 O O   . VAL B 1 404 ? 17.654 -111.910 -11.844 1.00 85.35  ? 402 VAL B O   1 
ATOM 6659 C CB  . VAL B 1 404 ? 20.142 -112.748 -9.808  1.00 83.70  ? 402 VAL B CB  1 
ATOM 6660 C CG1 . VAL B 1 404 ? 20.202 -113.731 -10.969 1.00 91.41  ? 402 VAL B CG1 1 
ATOM 6661 C CG2 . VAL B 1 404 ? 21.551 -112.409 -9.357  1.00 87.81  ? 402 VAL B CG2 1 
ATOM 6662 N N   . GLU B 1 405 ? 17.100 -112.290 -9.667  1.00 88.28  ? 403 GLU B N   1 
ATOM 6663 C CA  . GLU B 1 405 ? 15.790 -112.874 -9.897  1.00 88.51  ? 403 GLU B CA  1 
ATOM 6664 C C   . GLU B 1 405 ? 14.876 -111.926 -10.664 1.00 86.87  ? 403 GLU B C   1 
ATOM 6665 O O   . GLU B 1 405 ? 13.887 -112.387 -11.216 1.00 102.74 ? 403 GLU B O   1 
ATOM 6666 C CB  . GLU B 1 405 ? 15.076 -113.212 -8.588  1.00 96.76  ? 403 GLU B CB  1 
ATOM 6667 C CG  . GLU B 1 405 ? 15.619 -114.448 -7.876  1.00 118.08 ? 403 GLU B CG  1 
ATOM 6668 C CD  . GLU B 1 405 ? 15.146 -114.624 -6.435  1.00 137.62 ? 403 GLU B CD  1 
ATOM 6669 O OE1 . GLU B 1 405 ? 14.278 -113.843 -5.971  1.00 134.57 ? 403 GLU B OE1 1 
ATOM 6670 O OE2 . GLU B 1 405 ? 15.683 -115.536 -5.759  1.00 154.97 ? 403 GLU B OE2 1 
ATOM 6671 N N   . LYS B 1 406 ? 15.168 -110.619 -10.668 1.00 83.57  ? 404 LYS B N   1 
ATOM 6672 C CA  . LYS B 1 406 ? 14.324 -109.663 -11.362 1.00 87.90  ? 404 LYS B CA  1 
ATOM 6673 C C   . LYS B 1 406 ? 15.138 -108.935 -12.424 1.00 90.79  ? 404 LYS B C   1 
ATOM 6674 O O   . LYS B 1 406 ? 15.055 -107.718 -12.533 1.00 104.21 ? 404 LYS B O   1 
ATOM 6675 C CB  . LYS B 1 406 ? 13.711 -108.663 -10.374 1.00 97.12  ? 404 LYS B CB  1 
ATOM 6676 C CG  . LYS B 1 406 ? 12.754 -109.266 -9.370  1.00 107.03 ? 404 LYS B CG  1 
ATOM 6677 C CD  . LYS B 1 406 ? 12.137 -108.241 -8.427  1.00 112.57 ? 404 LYS B CD  1 
ATOM 6678 C CE  . LYS B 1 406 ? 11.091 -108.890 -7.584  1.00 125.79 ? 404 LYS B CE  1 
ATOM 6679 N NZ  . LYS B 1 406 ? 10.148 -107.915 -7.029  1.00 136.15 ? 404 LYS B NZ  1 
ATOM 6680 N N   . SER B 1 407 ? 15.906 -109.666 -13.233 1.00 93.33  ? 405 SER B N   1 
ATOM 6681 C CA  . SER B 1 407 ? 16.748 -108.982 -14.201 1.00 98.51  ? 405 SER B CA  1 
ATOM 6682 C C   . SER B 1 407 ? 16.587 -109.561 -15.606 1.00 103.05 ? 405 SER B C   1 
ATOM 6683 O O   . SER B 1 407 ? 16.977 -110.700 -15.870 1.00 109.57 ? 405 SER B O   1 
ATOM 6684 C CB  . SER B 1 407 ? 18.193 -108.984 -13.751 1.00 92.16  ? 405 SER B CB  1 
ATOM 6685 O OG  . SER B 1 407 ? 19.004 -108.225 -14.635 1.00 88.71  ? 405 SER B OG  1 
ATOM 6686 N N   . VAL B 1 408 ? 16.119 -108.700 -16.521 1.00 99.21  ? 406 VAL B N   1 
ATOM 6687 C CA  . VAL B 1 408 ? 16.115 -108.965 -17.946 1.00 95.11  ? 406 VAL B CA  1 
ATOM 6688 C C   . VAL B 1 408 ? 17.439 -109.602 -18.383 1.00 98.96  ? 406 VAL B C   1 
ATOM 6689 O O   . VAL B 1 408 ? 17.423 -110.598 -19.104 1.00 110.18 ? 406 VAL B O   1 
ATOM 6690 C CB  . VAL B 1 408 ? 15.805 -107.645 -18.672 1.00 92.03  ? 406 VAL B CB  1 
ATOM 6691 C CG1 . VAL B 1 408 ? 15.937 -107.765 -20.187 1.00 107.16 ? 406 VAL B CG1 1 
ATOM 6692 C CG2 . VAL B 1 408 ? 14.414 -107.138 -18.307 1.00 86.39  ? 406 VAL B CG2 1 
ATOM 6693 N N   . GLY B 1 409 ? 18.555 -109.087 -17.853 1.00 94.38  ? 407 GLY B N   1 
ATOM 6694 C CA  . GLY B 1 409 ? 19.900 -109.416 -18.302 1.00 94.65  ? 407 GLY B CA  1 
ATOM 6695 C C   . GLY B 1 409 ? 20.241 -110.911 -18.351 1.00 93.59  ? 407 GLY B C   1 
ATOM 6696 O O   . GLY B 1 409 ? 21.223 -111.289 -18.988 1.00 81.38  ? 407 GLY B O   1 
ATOM 6697 N N   . VAL B 1 410 ? 19.462 -111.746 -17.654 1.00 94.75  ? 408 VAL B N   1 
ATOM 6698 C CA  . VAL B 1 410 ? 19.651 -113.193 -17.665 1.00 103.49 ? 408 VAL B CA  1 
ATOM 6699 C C   . VAL B 1 410 ? 19.423 -113.761 -19.075 1.00 113.58 ? 408 VAL B C   1 
ATOM 6700 O O   . VAL B 1 410 ? 19.828 -114.892 -19.375 1.00 113.69 ? 408 VAL B O   1 
ATOM 6701 C CB  . VAL B 1 410 ? 18.690 -113.837 -16.647 1.00 111.63 ? 408 VAL B CB  1 
ATOM 6702 C CG1 . VAL B 1 410 ? 18.823 -115.361 -16.654 1.00 128.25 ? 408 VAL B CG1 1 
ATOM 6703 C CG2 . VAL B 1 410 ? 18.843 -113.266 -15.236 1.00 107.57 ? 408 VAL B CG2 1 
ATOM 6704 N N   . ILE B 1 411 ? 18.766 -112.965 -19.939 1.00 109.39 ? 409 ILE B N   1 
ATOM 6705 C CA  . ILE B 1 411 ? 18.395 -113.376 -21.288 1.00 105.69 ? 409 ILE B CA  1 
ATOM 6706 C C   . ILE B 1 411 ? 19.630 -113.475 -22.196 1.00 106.73 ? 409 ILE B C   1 
ATOM 6707 O O   . ILE B 1 411 ? 19.553 -113.994 -23.314 1.00 108.26 ? 409 ILE B O   1 
ATOM 6708 C CB  . ILE B 1 411 ? 17.339 -112.412 -21.861 1.00 104.63 ? 409 ILE B CB  1 
ATOM 6709 C CG1 . ILE B 1 411 ? 16.489 -113.069 -22.947 1.00 101.38 ? 409 ILE B CG1 1 
ATOM 6710 C CG2 . ILE B 1 411 ? 17.983 -111.112 -22.350 1.00 111.08 ? 409 ILE B CG2 1 
ATOM 6711 C CD1 . ILE B 1 411 ? 15.297 -112.231 -23.374 1.00 104.18 ? 409 ILE B CD1 1 
ATOM 6712 N N   . THR B 1 412 ? 20.783 -112.981 -21.729 1.00 107.37 ? 410 THR B N   1 
ATOM 6713 C CA  . THR B 1 412 ? 22.041 -113.141 -22.449 1.00 108.18 ? 410 THR B CA  1 
ATOM 6714 C C   . THR B 1 412 ? 22.425 -114.627 -22.539 1.00 106.43 ? 410 THR B C   1 
ATOM 6715 O O   . THR B 1 412 ? 23.279 -114.994 -23.344 1.00 108.23 ? 410 THR B O   1 
ATOM 6716 C CB  . THR B 1 412 ? 23.127 -112.292 -21.775 1.00 102.12 ? 410 THR B CB  1 
ATOM 6717 O OG1 . THR B 1 412 ? 22.667 -110.946 -21.698 1.00 98.18  ? 410 THR B OG1 1 
ATOM 6718 C CG2 . THR B 1 412 ? 24.430 -112.210 -22.553 1.00 94.17  ? 410 THR B CG2 1 
ATOM 6719 N N   . ALA B 1 413 ? 21.779 -115.488 -21.730 1.00 102.78 ? 411 ALA B N   1 
ATOM 6720 C CA  . ALA B 1 413 ? 22.038 -116.924 -21.717 1.00 102.41 ? 411 ALA B CA  1 
ATOM 6721 C C   . ALA B 1 413 ? 21.196 -117.681 -22.753 1.00 102.92 ? 411 ALA B C   1 
ATOM 6722 O O   . ALA B 1 413 ? 21.621 -118.756 -23.191 1.00 88.21  ? 411 ALA B O   1 
ATOM 6723 C CB  . ALA B 1 413 ? 21.800 -117.473 -20.323 1.00 107.13 ? 411 ALA B CB  1 
ATOM 6724 N N   . VAL B 1 414 ? 20.021 -117.116 -23.126 1.00 98.92  ? 412 VAL B N   1 
ATOM 6725 C CA  . VAL B 1 414 ? 19.098 -117.675 -24.112 1.00 94.49  ? 412 VAL B CA  1 
ATOM 6726 C C   . VAL B 1 414 ? 19.439 -117.158 -25.508 1.00 100.17 ? 412 VAL B C   1 
ATOM 6727 O O   . VAL B 1 414 ? 18.701 -117.420 -26.452 1.00 103.74 ? 412 VAL B O   1 
ATOM 6728 C CB  . VAL B 1 414 ? 17.600 -117.401 -23.851 1.00 98.53  ? 412 VAL B CB  1 
ATOM 6729 C CG1 . VAL B 1 414 ? 17.202 -117.683 -22.403 1.00 118.38 ? 412 VAL B CG1 1 
ATOM 6730 C CG2 . VAL B 1 414 ? 17.171 -115.997 -24.285 1.00 88.61  ? 412 VAL B CG2 1 
ATOM 6731 N N   . ASN B 1 415 ? 20.554 -116.433 -25.621 1.00 128.58 ? 413 ASN B N   1 
ATOM 6732 C CA  . ASN B 1 415 ? 20.936 -115.723 -26.835 1.00 134.44 ? 413 ASN B CA  1 
ATOM 6733 C C   . ASN B 1 415 ? 21.439 -116.699 -27.911 1.00 117.29 ? 413 ASN B C   1 
ATOM 6734 O O   . ASN B 1 415 ? 20.988 -116.638 -29.054 1.00 106.69 ? 413 ASN B O   1 
ATOM 6735 C CB  . ASN B 1 415 ? 21.896 -114.591 -26.478 1.00 130.40 ? 413 ASN B CB  1 
ATOM 6736 C CG  . ASN B 1 415 ? 21.812 -113.443 -27.451 1.00 130.47 ? 413 ASN B CG  1 
ATOM 6737 O OD1 . ASN B 1 415 ? 20.710 -113.000 -27.803 1.00 131.00 ? 413 ASN B OD1 1 
ATOM 6738 N ND2 . ASN B 1 415 ? 22.963 -112.947 -27.875 1.00 120.38 ? 413 ASN B ND2 1 
ATOM 6739 N N   . PRO B 1 416 ? 22.373 -117.643 -27.612 1.00 92.39  ? 414 PRO B N   1 
ATOM 6740 C CA  . PRO B 1 416 ? 22.831 -118.637 -28.594 1.00 85.18  ? 414 PRO B CA  1 
ATOM 6741 C C   . PRO B 1 416 ? 21.841 -119.689 -29.095 1.00 86.14  ? 414 PRO B C   1 
ATOM 6742 O O   . PRO B 1 416 ? 22.208 -120.483 -29.953 1.00 84.09  ? 414 PRO B O   1 
ATOM 6743 C CB  . PRO B 1 416 ? 24.017 -119.346 -27.907 1.00 73.61  ? 414 PRO B CB  1 
ATOM 6744 C CG  . PRO B 1 416 ? 24.427 -118.410 -26.809 1.00 80.15  ? 414 PRO B CG  1 
ATOM 6745 C CD  . PRO B 1 416 ? 23.124 -117.738 -26.351 1.00 91.84  ? 414 PRO B CD  1 
ATOM 6746 N N   . HIS B 1 417 ? 20.634 -119.757 -28.520 1.00 92.32  ? 415 HIS B N   1 
ATOM 6747 C CA  . HIS B 1 417 ? 19.585 -120.656 -29.002 1.00 89.81  ? 415 HIS B CA  1 
ATOM 6748 C C   . HIS B 1 417 ? 18.513 -119.900 -29.775 1.00 77.77  ? 415 HIS B C   1 
ATOM 6749 O O   . HIS B 1 417 ? 17.882 -120.478 -30.651 1.00 81.40  ? 415 HIS B O   1 
ATOM 6750 C CB  . HIS B 1 417 ? 18.815 -121.363 -27.873 1.00 96.28  ? 415 HIS B CB  1 
ATOM 6751 C CG  . HIS B 1 417 ? 19.656 -121.770 -26.716 1.00 89.71  ? 415 HIS B CG  1 
ATOM 6752 N ND1 . HIS B 1 417 ? 19.490 -121.206 -25.474 1.00 91.80  ? 415 HIS B ND1 1 
ATOM 6753 C CD2 . HIS B 1 417 ? 20.626 -122.677 -26.591 1.00 89.02  ? 415 HIS B CD2 1 
ATOM 6754 C CE1 . HIS B 1 417 ? 20.373 -121.730 -24.641 1.00 99.23  ? 415 HIS B CE1 1 
ATOM 6755 N NE2 . HIS B 1 417 ? 21.070 -122.627 -25.301 1.00 95.78  ? 415 HIS B NE2 1 
ATOM 6756 N N   . ILE B 1 418 ? 18.258 -118.650 -29.374 1.00 74.25  ? 416 ILE B N   1 
ATOM 6757 C CA  . ILE B 1 418 ? 17.166 -117.850 -29.915 1.00 85.91  ? 416 ILE B CA  1 
ATOM 6758 C C   . ILE B 1 418 ? 17.698 -116.794 -30.890 1.00 93.29  ? 416 ILE B C   1 
ATOM 6759 O O   . ILE B 1 418 ? 16.955 -116.322 -31.753 1.00 99.95  ? 416 ILE B O   1 
ATOM 6760 C CB  . ILE B 1 418 ? 16.323 -117.235 -28.773 1.00 86.94  ? 416 ILE B CB  1 
ATOM 6761 C CG1 . ILE B 1 418 ? 15.139 -118.136 -28.396 1.00 78.13  ? 416 ILE B CG1 1 
ATOM 6762 C CG2 . ILE B 1 418 ? 15.833 -115.810 -29.068 1.00 92.70  ? 416 ILE B CG2 1 
ATOM 6763 C CD1 . ILE B 1 418 ? 14.157 -117.452 -27.468 1.00 79.75  ? 416 ILE B CD1 1 
ATOM 6764 N N   . GLY B 1 419 ? 18.965 -116.406 -30.727 1.00 90.76  ? 417 GLY B N   1 
ATOM 6765 C CA  . GLY B 1 419 ? 19.561 -115.379 -31.564 1.00 101.65 ? 417 GLY B CA  1 
ATOM 6766 C C   . GLY B 1 419 ? 19.331 -113.991 -30.973 1.00 120.90 ? 417 GLY B C   1 
ATOM 6767 O O   . GLY B 1 419 ? 18.322 -113.744 -30.311 1.00 137.93 ? 417 GLY B O   1 
ATOM 6768 N N   . TYR B 1 420 ? 20.269 -113.079 -31.253 1.00 130.93 ? 418 TYR B N   1 
ATOM 6769 C CA  . TYR B 1 420 ? 20.278 -111.751 -30.659 1.00 121.00 ? 418 TYR B CA  1 
ATOM 6770 C C   . TYR B 1 420 ? 19.041 -110.952 -31.078 1.00 126.33 ? 418 TYR B C   1 
ATOM 6771 O O   . TYR B 1 420 ? 18.600 -110.100 -30.322 1.00 137.05 ? 418 TYR B O   1 
ATOM 6772 C CB  . TYR B 1 420 ? 21.595 -111.066 -31.038 1.00 120.95 ? 418 TYR B CB  1 
ATOM 6773 C CG  . TYR B 1 420 ? 21.781 -109.649 -30.508 1.00 113.74 ? 418 TYR B CG  1 
ATOM 6774 C CD1 . TYR B 1 420 ? 21.303 -108.552 -31.218 1.00 107.50 ? 418 TYR B CD1 1 
ATOM 6775 C CD2 . TYR B 1 420 ? 22.462 -109.403 -29.316 1.00 107.22 ? 418 TYR B CD2 1 
ATOM 6776 C CE1 . TYR B 1 420 ? 21.472 -107.258 -30.747 1.00 99.36  ? 418 TYR B CE1 1 
ATOM 6777 C CE2 . TYR B 1 420 ? 22.638 -108.113 -28.838 1.00 99.31  ? 418 TYR B CE2 1 
ATOM 6778 C CZ  . TYR B 1 420 ? 22.142 -107.037 -29.556 1.00 90.89  ? 418 TYR B CZ  1 
ATOM 6779 O OH  . TYR B 1 420 ? 22.294 -105.755 -29.112 1.00 80.44  ? 418 TYR B OH  1 
ATOM 6780 N N   . GLU B 1 421 ? 18.475 -111.218 -32.264 1.00 127.28 ? 419 GLU B N   1 
ATOM 6781 C CA  . GLU B 1 421 ? 17.370 -110.412 -32.773 1.00 126.98 ? 419 GLU B CA  1 
ATOM 6782 C C   . GLU B 1 421 ? 16.059 -110.758 -32.046 1.00 111.23 ? 419 GLU B C   1 
ATOM 6783 O O   . GLU B 1 421 ? 15.316 -109.843 -31.698 1.00 79.43  ? 419 GLU B O   1 
ATOM 6784 C CB  . GLU B 1 421 ? 17.317 -110.428 -34.310 1.00 137.25 ? 419 GLU B CB  1 
ATOM 6785 C CG  . GLU B 1 421 ? 18.424 -109.617 -34.991 1.00 146.37 ? 419 GLU B CG  1 
ATOM 6786 C CD  . GLU B 1 421 ? 18.298 -109.427 -36.498 1.00 159.15 ? 419 GLU B CD  1 
ATOM 6787 O OE1 . GLU B 1 421 ? 17.387 -110.024 -37.111 1.00 164.86 ? 419 GLU B OE1 1 
ATOM 6788 O OE2 . GLU B 1 421 ? 19.111 -108.660 -37.059 1.00 161.35 ? 419 GLU B OE2 1 
ATOM 6789 N N   . VAL B 1 422 ? 15.791 -112.051 -31.789 1.00 122.12 ? 420 VAL B N   1 
ATOM 6790 C CA  . VAL B 1 422 ? 14.540 -112.498 -31.180 1.00 131.16 ? 420 VAL B CA  1 
ATOM 6791 C C   . VAL B 1 422 ? 14.540 -112.184 -29.681 1.00 131.79 ? 420 VAL B C   1 
ATOM 6792 O O   . VAL B 1 422 ? 13.470 -111.996 -29.094 1.00 122.61 ? 420 VAL B O   1 
ATOM 6793 C CB  . VAL B 1 422 ? 14.294 -114.002 -31.424 1.00 128.42 ? 420 VAL B CB  1 
ATOM 6794 C CG1 . VAL B 1 422 ? 13.041 -114.521 -30.720 1.00 124.32 ? 420 VAL B CG1 1 
ATOM 6795 C CG2 . VAL B 1 422 ? 14.233 -114.336 -32.908 1.00 136.94 ? 420 VAL B CG2 1 
ATOM 6796 N N   . ALA B 1 423 ? 15.740 -112.121 -29.080 1.00 132.64 ? 421 ALA B N   1 
ATOM 6797 C CA  . ALA B 1 423 ? 15.919 -111.859 -27.659 1.00 122.34 ? 421 ALA B CA  1 
ATOM 6798 C C   . ALA B 1 423 ? 15.945 -110.350 -27.372 1.00 117.09 ? 421 ALA B C   1 
ATOM 6799 O O   . ALA B 1 423 ? 15.556 -109.913 -26.294 1.00 115.78 ? 421 ALA B O   1 
ATOM 6800 C CB  . ALA B 1 423 ? 17.186 -112.553 -27.182 1.00 117.15 ? 421 ALA B CB  1 
ATOM 6801 N N   . SER B 1 424 ? 16.431 -109.552 -28.330 1.00 112.94 ? 422 SER B N   1 
ATOM 6802 C CA  . SER B 1 424 ? 16.439 -108.099 -28.218 1.00 109.79 ? 422 SER B CA  1 
ATOM 6803 C C   . SER B 1 424 ? 15.020 -107.555 -28.144 1.00 107.39 ? 422 SER B C   1 
ATOM 6804 O O   . SER B 1 424 ? 14.804 -106.564 -27.460 1.00 103.79 ? 422 SER B O   1 
ATOM 6805 C CB  . SER B 1 424 ? 17.183 -107.450 -29.351 1.00 116.51 ? 422 SER B CB  1 
ATOM 6806 O OG  . SER B 1 424 ? 18.571 -107.444 -29.077 1.00 124.12 ? 422 SER B OG  1 
ATOM 6807 N N   . ARG B 1 425 ? 14.076 -108.201 -28.844 1.00 113.30 ? 423 ARG B N   1 
ATOM 6808 C CA  . ARG B 1 425 ? 12.684 -107.769 -28.874 1.00 112.34 ? 423 ARG B CA  1 
ATOM 6809 C C   . ARG B 1 425 ? 11.953 -108.204 -27.602 1.00 104.07 ? 423 ARG B C   1 
ATOM 6810 O O   . ARG B 1 425 ? 11.128 -107.442 -27.084 1.00 97.98  ? 423 ARG B O   1 
ATOM 6811 C CB  . ARG B 1 425 ? 11.970 -108.252 -30.144 1.00 114.90 ? 423 ARG B CB  1 
ATOM 6812 C CG  . ARG B 1 425 ? 12.390 -107.531 -31.421 1.00 115.31 ? 423 ARG B CG  1 
ATOM 6813 C CD  . ARG B 1 425 ? 11.538 -107.914 -32.627 1.00 120.94 ? 423 ARG B CD  1 
ATOM 6814 N NE  . ARG B 1 425 ? 11.688 -109.339 -32.951 1.00 136.95 ? 423 ARG B NE  1 
ATOM 6815 C CZ  . ARG B 1 425 ? 10.856 -110.325 -32.596 1.00 142.91 ? 423 ARG B CZ  1 
ATOM 6816 N NH1 . ARG B 1 425 ? 9.779  -110.073 -31.866 1.00 138.15 ? 423 ARG B NH1 1 
ATOM 6817 N NH2 . ARG B 1 425 ? 11.130 -111.577 -32.929 1.00 148.01 ? 423 ARG B NH2 1 
ATOM 6818 N N   . ILE B 1 426 ? 12.263 -109.417 -27.105 1.00 108.60 ? 424 ILE B N   1 
ATOM 6819 C CA  . ILE B 1 426 ? 11.695 -109.923 -25.857 1.00 118.46 ? 424 ILE B CA  1 
ATOM 6820 C C   . ILE B 1 426 ? 12.187 -109.082 -24.671 1.00 122.47 ? 424 ILE B C   1 
ATOM 6821 O O   . ILE B 1 426 ? 11.460 -108.913 -23.687 1.00 109.10 ? 424 ILE B O   1 
ATOM 6822 C CB  . ILE B 1 426 ? 12.022 -111.422 -25.669 1.00 108.35 ? 424 ILE B CB  1 
ATOM 6823 C CG1 . ILE B 1 426 ? 11.325 -112.289 -26.713 1.00 103.95 ? 424 ILE B CG1 1 
ATOM 6824 C CG2 . ILE B 1 426 ? 11.709 -111.898 -24.248 1.00 108.17 ? 424 ILE B CG2 1 
ATOM 6825 C CD1 . ILE B 1 426 ? 11.793 -113.732 -26.717 1.00 109.53 ? 424 ILE B CD1 1 
ATOM 6826 N N   . ALA B 1 427 ? 13.431 -108.582 -24.771 1.00 113.96 ? 425 ALA B N   1 
ATOM 6827 C CA  . ALA B 1 427 ? 14.091 -107.863 -23.691 1.00 97.63  ? 425 ALA B CA  1 
ATOM 6828 C C   . ALA B 1 427 ? 13.627 -106.411 -23.654 1.00 99.38  ? 425 ALA B C   1 
ATOM 6829 O O   . ALA B 1 427 ? 13.533 -105.829 -22.586 1.00 100.68 ? 425 ALA B O   1 
ATOM 6830 C CB  . ALA B 1 427 ? 15.592 -107.944 -23.848 1.00 92.91  ? 425 ALA B CB  1 
ATOM 6831 N N   . ARG B 1 428 ? 13.375 -105.822 -24.828 1.00 106.63 ? 426 ARG B N   1 
ATOM 6832 C CA  . ARG B 1 428 ? 12.840 -104.472 -24.929 1.00 109.74 ? 426 ARG B CA  1 
ATOM 6833 C C   . ARG B 1 428 ? 11.393 -104.453 -24.431 1.00 101.75 ? 426 ARG B C   1 
ATOM 6834 O O   . ARG B 1 428 ? 10.952 -103.445 -23.891 1.00 98.65  ? 426 ARG B O   1 
ATOM 6835 C CB  . ARG B 1 428 ? 13.003 -103.976 -26.375 1.00 122.75 ? 426 ARG B CB  1 
ATOM 6836 C CG  . ARG B 1 428 ? 12.554 -102.559 -26.712 1.00 132.14 ? 426 ARG B CG  1 
ATOM 6837 C CD  . ARG B 1 428 ? 11.219 -102.541 -27.454 1.00 140.28 ? 426 ARG B CD  1 
ATOM 6838 N NE  . ARG B 1 428 ? 11.346 -103.154 -28.783 1.00 135.28 ? 426 ARG B NE  1 
ATOM 6839 C CZ  . ARG B 1 428 ? 10.614 -104.152 -29.295 1.00 129.76 ? 426 ARG B CZ  1 
ATOM 6840 N NH1 . ARG B 1 428 ? 9.548  -104.632 -28.669 1.00 119.46 ? 426 ARG B NH1 1 
ATOM 6841 N NH2 . ARG B 1 428 ? 10.933 -104.633 -30.481 1.00 135.01 ? 426 ARG B NH2 1 
ATOM 6842 N N   . GLU B 1 429 ? 10.667 -105.566 -24.604 1.00 97.52  ? 427 GLU B N   1 
ATOM 6843 C CA  . GLU B 1 429 ? 9.275  -105.661 -24.180 1.00 99.08  ? 427 GLU B CA  1 
ATOM 6844 C C   . GLU B 1 429 ? 9.202  -105.830 -22.657 1.00 111.26 ? 427 GLU B C   1 
ATOM 6845 O O   . GLU B 1 429 ? 8.331  -105.247 -22.003 1.00 99.63  ? 427 GLU B O   1 
ATOM 6846 C CB  . GLU B 1 429 ? 8.560  -106.793 -24.925 1.00 101.36 ? 427 GLU B CB  1 
ATOM 6847 C CG  . GLU B 1 429 ? 7.045  -106.794 -24.712 1.00 104.46 ? 427 GLU B CG  1 
ATOM 6848 C CD  . GLU B 1 429 ? 6.231  -107.768 -25.570 1.00 106.22 ? 427 GLU B CD  1 
ATOM 6849 O OE1 . GLU B 1 429 ? 6.336  -108.986 -25.338 1.00 118.20 ? 427 GLU B OE1 1 
ATOM 6850 O OE2 . GLU B 1 429 ? 5.481  -107.341 -26.472 1.00 101.81 ? 427 GLU B OE2 1 
ATOM 6851 N N   . ALA B 1 430 ? 10.131 -106.631 -22.105 1.00 115.25 ? 428 ALA B N   1 
ATOM 6852 C CA  . ALA B 1 430 ? 10.152 -106.980 -20.688 1.00 101.11 ? 428 ALA B CA  1 
ATOM 6853 C C   . ALA B 1 430 ? 10.532 -105.777 -19.830 1.00 98.63  ? 428 ALA B C   1 
ATOM 6854 O O   . ALA B 1 430 ? 10.014 -105.629 -18.729 1.00 102.62 ? 428 ALA B O   1 
ATOM 6855 C CB  . ALA B 1 430 ? 11.103 -108.135 -20.452 1.00 95.22  ? 428 ALA B CB  1 
ATOM 6856 N N   . THR B 1 431 ? 11.459 -104.938 -20.322 1.00 99.17  ? 429 THR B N   1 
ATOM 6857 C CA  . THR B 1 431 ? 11.880 -103.743 -19.599 1.00 93.78  ? 429 THR B CA  1 
ATOM 6858 C C   . THR B 1 431 ? 10.711 -102.765 -19.561 1.00 91.55  ? 429 THR B C   1 
ATOM 6859 O O   . THR B 1 431 ? 10.388 -102.267 -18.490 1.00 110.66 ? 429 THR B O   1 
ATOM 6860 C CB  . THR B 1 431 ? 13.146 -103.122 -20.192 1.00 88.37  ? 429 THR B CB  1 
ATOM 6861 O OG1 . THR B 1 431 ? 13.015 -103.330 -21.593 1.00 109.73 ? 429 THR B OG1 1 
ATOM 6862 C CG2 . THR B 1 431 ? 14.430 -103.798 -19.737 1.00 81.22  ? 429 THR B CG2 1 
ATOM 6863 N N   . LEU B 1 432 ? 10.058 -102.538 -20.709 1.00 90.23  ? 430 LEU B N   1 
ATOM 6864 C CA  . LEU B 1 432 ? 8.902  -101.653 -20.777 1.00 93.65  ? 430 LEU B CA  1 
ATOM 6865 C C   . LEU B 1 432 ? 7.752  -102.187 -19.907 1.00 93.12  ? 430 LEU B C   1 
ATOM 6866 O O   . LEU B 1 432 ? 7.333  -101.507 -18.980 1.00 86.43  ? 430 LEU B O   1 
ATOM 6867 C CB  . LEU B 1 432 ? 8.454  -101.404 -22.222 1.00 96.50  ? 430 LEU B CB  1 
ATOM 6868 C CG  . LEU B 1 432 ? 9.129  -100.261 -22.996 1.00 100.18 ? 430 LEU B CG  1 
ATOM 6869 C CD1 . LEU B 1 432 ? 9.181  -99.024  -22.121 1.00 115.94 ? 430 LEU B CD1 1 
ATOM 6870 C CD2 . LEU B 1 432 ? 10.515 -100.548 -23.548 1.00 93.51  ? 430 LEU B CD2 1 
ATOM 6871 N N   . THR B 1 433 ? 7.236  -103.391 -20.193 1.00 94.93  ? 431 THR B N   1 
ATOM 6872 C CA  . THR B 1 433 ? 6.061  -103.907 -19.493 1.00 86.54  ? 431 THR B CA  1 
ATOM 6873 C C   . THR B 1 433 ? 6.397  -104.277 -18.048 1.00 88.65  ? 431 THR B C   1 
ATOM 6874 O O   . THR B 1 433 ? 5.531  -104.223 -17.181 1.00 86.34  ? 431 THR B O   1 
ATOM 6875 C CB  . THR B 1 433 ? 5.491  -105.116 -20.231 1.00 88.57  ? 431 THR B CB  1 
ATOM 6876 O OG1 . THR B 1 433 ? 6.578  -106.033 -20.308 1.00 86.93  ? 431 THR B OG1 1 
ATOM 6877 C CG2 . THR B 1 433 ? 4.964  -104.765 -21.611 1.00 93.30  ? 431 THR B CG2 1 
ATOM 6878 N N   . GLY B 1 434 ? 7.647  -104.688 -17.807 1.00 93.11  ? 432 GLY B N   1 
ATOM 6879 C CA  . GLY B 1 434 ? 8.108  -105.042 -16.476 1.00 84.44  ? 432 GLY B CA  1 
ATOM 6880 C C   . GLY B 1 434 ? 7.759  -106.479 -16.107 1.00 79.65  ? 432 GLY B C   1 
ATOM 6881 O O   . GLY B 1 434 ? 7.564  -106.790 -14.936 1.00 95.69  ? 432 GLY B O   1 
ATOM 6882 N N   . GLN B 1 435 ? 7.698  -107.362 -17.107 1.00 85.64  ? 433 GLN B N   1 
ATOM 6883 C CA  . GLN B 1 435 ? 7.359  -108.760 -16.875 1.00 92.81  ? 433 GLN B CA  1 
ATOM 6884 C C   . GLN B 1 435 ? 8.637  -109.591 -16.874 1.00 86.75  ? 433 GLN B C   1 
ATOM 6885 O O   . GLN B 1 435 ? 9.642  -109.157 -17.415 1.00 88.53  ? 433 GLN B O   1 
ATOM 6886 C CB  . GLN B 1 435 ? 6.328  -109.183 -17.920 1.00 91.22  ? 433 GLN B CB  1 
ATOM 6887 C CG  . GLN B 1 435 ? 5.084  -108.302 -17.893 1.00 90.05  ? 433 GLN B CG  1 
ATOM 6888 C CD  . GLN B 1 435 ? 4.188  -108.489 -19.087 1.00 94.76  ? 433 GLN B CD  1 
ATOM 6889 O OE1 . GLN B 1 435 ? 4.630  -108.466 -20.236 1.00 89.82  ? 433 GLN B OE1 1 
ATOM 6890 N NE2 . GLN B 1 435 ? 2.906  -108.646 -18.815 1.00 111.35 ? 433 GLN B NE2 1 
ATOM 6891 N N   . SER B 1 436 ? 8.596  -110.781 -16.266 1.00 90.88  ? 434 SER B N   1 
ATOM 6892 C CA  . SER B 1 436 ? 9.772  -111.641 -16.213 1.00 99.81  ? 434 SER B CA  1 
ATOM 6893 C C   . SER B 1 436 ? 10.109 -112.110 -17.626 1.00 108.63 ? 434 SER B C   1 
ATOM 6894 O O   . SER B 1 436 ? 9.233  -112.166 -18.494 1.00 133.28 ? 434 SER B O   1 
ATOM 6895 C CB  . SER B 1 436 ? 9.618  -112.818 -15.245 1.00 102.01 ? 434 SER B CB  1 
ATOM 6896 O OG  . SER B 1 436 ? 8.824  -113.878 -15.767 1.00 95.64  ? 434 SER B OG  1 
ATOM 6897 N N   . VAL B 1 437 ? 11.392 -112.433 -17.837 1.00 106.62 ? 435 VAL B N   1 
ATOM 6898 C CA  . VAL B 1 437 ? 11.895 -112.911 -19.117 1.00 109.34 ? 435 VAL B CA  1 
ATOM 6899 C C   . VAL B 1 437 ? 11.291 -114.277 -19.437 1.00 116.96 ? 435 VAL B C   1 
ATOM 6900 O O   . VAL B 1 437 ? 11.030 -114.575 -20.606 1.00 121.29 ? 435 VAL B O   1 
ATOM 6901 C CB  . VAL B 1 437 ? 13.437 -112.972 -19.094 1.00 103.35 ? 435 VAL B CB  1 
ATOM 6902 C CG1 . VAL B 1 437 ? 14.042 -113.640 -20.322 1.00 105.41 ? 435 VAL B CG1 1 
ATOM 6903 C CG2 . VAL B 1 437 ? 14.019 -111.587 -18.942 1.00 107.02 ? 435 VAL B CG2 1 
ATOM 6904 N N   . ARG B 1 438 ? 11.098 -115.091 -18.387 1.00 119.15 ? 436 ARG B N   1 
ATOM 6905 C CA  . ARG B 1 438 ? 10.547 -116.427 -18.539 1.00 122.36 ? 436 ARG B CA  1 
ATOM 6906 C C   . ARG B 1 438 ? 9.157  -116.334 -19.173 1.00 129.54 ? 436 ARG B C   1 
ATOM 6907 O O   . ARG B 1 438 ? 8.860  -117.101 -20.086 1.00 156.69 ? 436 ARG B O   1 
ATOM 6908 C CB  . ARG B 1 438 ? 10.522 -117.211 -17.216 1.00 119.29 ? 436 ARG B CB  1 
ATOM 6909 C CG  . ARG B 1 438 ? 9.809  -118.553 -17.320 1.00 127.76 ? 436 ARG B CG  1 
ATOM 6910 C CD  . ARG B 1 438 ? 9.516  -119.183 -15.983 1.00 125.85 ? 436 ARG B CD  1 
ATOM 6911 N NE  . ARG B 1 438 ? 10.782 -119.742 -15.507 1.00 129.47 ? 436 ARG B NE  1 
ATOM 6912 C CZ  . ARG B 1 438 ? 11.119 -121.029 -15.573 1.00 133.76 ? 436 ARG B CZ  1 
ATOM 6913 N NH1 . ARG B 1 438 ? 10.294 -121.931 -16.094 1.00 149.60 ? 436 ARG B NH1 1 
ATOM 6914 N NH2 . ARG B 1 438 ? 12.296 -121.420 -15.116 1.00 122.23 ? 436 ARG B NH2 1 
ATOM 6915 N N   . ASP B 1 439 ? 8.322  -115.404 -18.684 1.00 117.53 ? 437 ASP B N   1 
ATOM 6916 C CA  . ASP B 1 439 ? 6.924  -115.307 -19.083 1.00 114.88 ? 437 ASP B CA  1 
ATOM 6917 C C   . ASP B 1 439 ? 6.792  -114.729 -20.492 1.00 124.34 ? 437 ASP B C   1 
ATOM 6918 O O   . ASP B 1 439 ? 5.794  -114.976 -21.173 1.00 157.47 ? 437 ASP B O   1 
ATOM 6919 C CB  . ASP B 1 439 ? 6.117  -114.531 -18.054 1.00 103.54 ? 437 ASP B CB  1 
ATOM 6920 C CG  . ASP B 1 439 ? 6.094  -115.153 -16.666 1.00 102.07 ? 437 ASP B CG  1 
ATOM 6921 O OD1 . ASP B 1 439 ? 6.420  -116.350 -16.546 1.00 95.30  ? 437 ASP B OD1 1 
ATOM 6922 O OD2 . ASP B 1 439 ? 5.776  -114.428 -15.708 1.00 114.01 ? 437 ASP B OD2 1 
ATOM 6923 N N   . LEU B 1 440 ? 7.800  -113.970 -20.933 1.00 109.90 ? 438 LEU B N   1 
ATOM 6924 C CA  . LEU B 1 440 ? 7.828  -113.451 -22.292 1.00 101.16 ? 438 LEU B CA  1 
ATOM 6925 C C   . LEU B 1 440 ? 8.461  -114.449 -23.264 1.00 98.57  ? 438 LEU B C   1 
ATOM 6926 O O   . LEU B 1 440 ? 8.327  -114.304 -24.479 1.00 98.37  ? 438 LEU B O   1 
ATOM 6927 C CB  . LEU B 1 440 ? 8.551  -112.110 -22.280 1.00 99.88  ? 438 LEU B CB  1 
ATOM 6928 C CG  . LEU B 1 440 ? 7.637  -110.886 -22.163 1.00 92.92  ? 438 LEU B CG  1 
ATOM 6929 C CD1 . LEU B 1 440 ? 6.669  -110.953 -21.001 1.00 86.20  ? 438 LEU B CD1 1 
ATOM 6930 C CD2 . LEU B 1 440 ? 8.503  -109.671 -22.041 1.00 93.61  ? 438 LEU B CD2 1 
ATOM 6931 N N   . CYS B 1 441 ? 9.151  -115.464 -22.737 1.00 101.84 ? 439 CYS B N   1 
ATOM 6932 C CA  . CYS B 1 441 ? 9.650  -116.557 -23.560 1.00 106.81 ? 439 CYS B CA  1 
ATOM 6933 C C   . CYS B 1 441 ? 8.585  -117.639 -23.758 1.00 116.83 ? 439 CYS B C   1 
ATOM 6934 O O   . CYS B 1 441 ? 8.659  -118.398 -24.725 1.00 109.85 ? 439 CYS B O   1 
ATOM 6935 C CB  . CYS B 1 441 ? 10.944 -117.114 -22.980 1.00 109.15 ? 439 CYS B CB  1 
ATOM 6936 S SG  . CYS B 1 441 ? 12.295 -115.925 -23.174 1.00 114.83 ? 439 CYS B SG  1 
ATOM 6937 N N   . ARG B 1 442 ? 7.623  -117.732 -22.824 1.00 122.49 ? 440 ARG B N   1 
ATOM 6938 C CA  . ARG B 1 442 ? 6.481  -118.631 -22.922 1.00 122.95 ? 440 ARG B CA  1 
ATOM 6939 C C   . ARG B 1 442 ? 5.318  -117.967 -23.662 1.00 111.18 ? 440 ARG B C   1 
ATOM 6940 O O   . ARG B 1 442 ? 4.386  -118.651 -24.076 1.00 139.18 ? 440 ARG B O   1 
ATOM 6941 C CB  . ARG B 1 442 ? 5.902  -119.006 -21.550 1.00 133.36 ? 440 ARG B CB  1 
ATOM 6942 C CG  . ARG B 1 442 ? 6.702  -119.930 -20.644 1.00 135.17 ? 440 ARG B CG  1 
ATOM 6943 C CD  . ARG B 1 442 ? 6.392  -119.544 -19.193 1.00 147.80 ? 440 ARG B CD  1 
ATOM 6944 N NE  . ARG B 1 442 ? 4.994  -119.739 -18.788 1.00 139.37 ? 440 ARG B NE  1 
ATOM 6945 C CZ  . ARG B 1 442 ? 4.541  -119.441 -17.576 1.00 126.12 ? 440 ARG B CZ  1 
ATOM 6946 N NH1 . ARG B 1 442 ? 5.304  -118.775 -16.723 1.00 116.91 ? 440 ARG B NH1 1 
ATOM 6947 N NH2 . ARG B 1 442 ? 3.320  -119.786 -17.222 1.00 126.96 ? 440 ARG B NH2 1 
ATOM 6948 N N   . LYS B 1 443 ? 5.330  -116.633 -23.753 1.00 94.04  ? 441 LYS B N   1 
ATOM 6949 C CA  . LYS B 1 443 ? 4.344  -115.901 -24.534 1.00 106.68 ? 441 LYS B CA  1 
ATOM 6950 C C   . LYS B 1 443 ? 4.673  -116.052 -26.027 1.00 105.76 ? 441 LYS B C   1 
ATOM 6951 O O   . LYS B 1 443 ? 3.808  -116.331 -26.860 1.00 101.81 ? 441 LYS B O   1 
ATOM 6952 C CB  . LYS B 1 443 ? 4.240  -114.452 -24.024 1.00 108.07 ? 441 LYS B CB  1 
ATOM 6953 C CG  . LYS B 1 443 ? 3.507  -113.475 -24.955 1.00 106.34 ? 441 LYS B CG  1 
ATOM 6954 C CD  . LYS B 1 443 ? 3.391  -112.022 -24.510 1.00 100.03 ? 441 LYS B CD  1 
ATOM 6955 C CE  . LYS B 1 443 ? 3.632  -111.116 -25.692 1.00 105.30 ? 441 LYS B CE  1 
ATOM 6956 N NZ  . LYS B 1 443 ? 3.534  -109.688 -25.405 1.00 105.30 ? 441 LYS B NZ  1 
ATOM 6957 N N   . TYR B 1 444 ? 5.948  -115.873 -26.363 1.00 104.81 ? 442 TYR B N   1 
ATOM 6958 C CA  . TYR B 1 444 ? 6.431  -116.110 -27.712 1.00 105.08 ? 442 TYR B CA  1 
ATOM 6959 C C   . TYR B 1 444 ? 6.631  -117.602 -27.983 1.00 91.57  ? 442 TYR B C   1 
ATOM 6960 O O   . TYR B 1 444 ? 6.866  -117.978 -29.124 1.00 89.66  ? 442 TYR B O   1 
ATOM 6961 C CB  . TYR B 1 444 ? 7.722  -115.305 -27.914 1.00 119.74 ? 442 TYR B CB  1 
ATOM 6962 C CG  . TYR B 1 444 ? 7.538  -113.866 -28.403 1.00 128.75 ? 442 TYR B CG  1 
ATOM 6963 C CD1 . TYR B 1 444 ? 6.650  -112.967 -27.797 1.00 105.16 ? 442 TYR B CD1 1 
ATOM 6964 C CD2 . TYR B 1 444 ? 8.253  -113.421 -29.522 1.00 139.11 ? 442 TYR B CD2 1 
ATOM 6965 C CE1 . TYR B 1 444 ? 6.493  -111.679 -28.291 1.00 114.67 ? 442 TYR B CE1 1 
ATOM 6966 C CE2 . TYR B 1 444 ? 8.099  -112.139 -30.020 1.00 128.79 ? 442 TYR B CE2 1 
ATOM 6967 C CZ  . TYR B 1 444 ? 7.223  -111.264 -29.400 1.00 134.33 ? 442 TYR B CZ  1 
ATOM 6968 O OH  . TYR B 1 444 ? 7.132  -110.007 -29.935 1.00 119.62 ? 442 TYR B OH  1 
ATOM 6969 N N   . ASP B 1 445 ? 6.570  -118.446 -26.943 1.00 89.24  ? 443 ASP B N   1 
ATOM 6970 C CA  . ASP B 1 445 ? 6.801  -119.886 -27.054 1.00 87.35  ? 443 ASP B CA  1 
ATOM 6971 C C   . ASP B 1 445 ? 8.112  -120.154 -27.805 1.00 84.77  ? 443 ASP B C   1 
ATOM 6972 O O   . ASP B 1 445 ? 8.135  -120.926 -28.762 1.00 88.42  ? 443 ASP B O   1 
ATOM 6973 C CB  . ASP B 1 445 ? 5.552  -120.579 -27.592 1.00 85.69  ? 443 ASP B CB  1 
ATOM 6974 C CG  . ASP B 1 445 ? 5.557  -122.100 -27.704 1.00 96.40  ? 443 ASP B CG  1 
ATOM 6975 O OD1 . ASP B 1 445 ? 6.036  -122.776 -26.767 1.00 86.90  ? 443 ASP B OD1 1 
ATOM 6976 O OD2 . ASP B 1 445 ? 5.024  -122.608 -28.715 1.00 113.83 ? 443 ASP B OD2 1 
ATOM 6977 N N   . VAL B 1 446 ? 9.204  -119.508 -27.367 1.00 85.37  ? 444 VAL B N   1 
ATOM 6978 C CA  . VAL B 1 446 ? 10.462 -119.482 -28.116 1.00 92.12  ? 444 VAL B CA  1 
ATOM 6979 C C   . VAL B 1 446 ? 11.460 -120.483 -27.524 1.00 95.50  ? 444 VAL B C   1 
ATOM 6980 O O   . VAL B 1 446 ? 12.384 -120.913 -28.214 1.00 93.99  ? 444 VAL B O   1 
ATOM 6981 C CB  . VAL B 1 446 ? 11.100 -118.079 -28.230 1.00 90.27  ? 444 VAL B CB  1 
ATOM 6982 C CG1 . VAL B 1 446 ? 10.504 -117.245 -29.365 1.00 82.39  ? 444 VAL B CG1 1 
ATOM 6983 C CG2 . VAL B 1 446 ? 11.021 -117.328 -26.906 1.00 98.63  ? 444 VAL B CG2 1 
ATOM 6984 N N   . LEU B 1 447 ? 11.279 -120.813 -26.238 1.00 101.81 ? 445 LEU B N   1 
ATOM 6985 C CA  . LEU B 1 447 ? 11.956 -121.927 -25.578 1.00 95.92  ? 445 LEU B CA  1 
ATOM 6986 C C   . LEU B 1 447 ? 10.958 -122.598 -24.634 1.00 100.53 ? 445 LEU B C   1 
ATOM 6987 O O   . LEU B 1 447 ? 10.048 -121.939 -24.126 1.00 106.81 ? 445 LEU B O   1 
ATOM 6988 C CB  . LEU B 1 447 ? 13.182 -121.434 -24.807 1.00 90.80  ? 445 LEU B CB  1 
ATOM 6989 C CG  . LEU B 1 447 ? 14.425 -121.090 -25.633 1.00 95.80  ? 445 LEU B CG  1 
ATOM 6990 C CD1 . LEU B 1 447 ? 15.527 -120.458 -24.797 1.00 100.09 ? 445 LEU B CD1 1 
ATOM 6991 C CD2 . LEU B 1 447 ? 14.978 -122.314 -26.321 1.00 104.11 ? 445 LEU B CD2 1 
ATOM 6992 N N   . SER B 1 448 ? 11.122 -123.906 -24.390 1.00 103.80 ? 446 SER B N   1 
ATOM 6993 C CA  . SER B 1 448 ? 10.216 -124.620 -23.498 1.00 107.90 ? 446 SER B CA  1 
ATOM 6994 C C   . SER B 1 448 ? 10.556 -124.284 -22.049 1.00 109.36 ? 446 SER B C   1 
ATOM 6995 O O   . SER B 1 448 ? 11.599 -123.696 -21.769 1.00 113.86 ? 446 SER B O   1 
ATOM 6996 C CB  . SER B 1 448 ? 10.237 -126.107 -23.733 1.00 103.98 ? 446 SER B CB  1 
ATOM 6997 O OG  . SER B 1 448 ? 11.508 -126.650 -23.417 1.00 95.16  ? 446 SER B OG  1 
ATOM 6998 N N   . ASP B 1 449 ? 9.661  -124.659 -21.132 1.00 107.35 ? 447 ASP B N   1 
ATOM 6999 C CA  . ASP B 1 449 ? 9.845  -124.355 -19.722 1.00 99.38  ? 447 ASP B CA  1 
ATOM 7000 C C   . ASP B 1 449 ? 11.007 -125.165 -19.152 1.00 91.28  ? 447 ASP B C   1 
ATOM 7001 O O   . ASP B 1 449 ? 11.757 -124.656 -18.344 1.00 85.67  ? 447 ASP B O   1 
ATOM 7002 C CB  . ASP B 1 449 ? 8.507  -124.396 -19.009 1.00 100.11 ? 447 ASP B CB  1 
ATOM 7003 C CG  . ASP B 1 449 ? 7.588  -123.275 -19.472 1.00 111.77 ? 447 ASP B CG  1 
ATOM 7004 O OD1 . ASP B 1 449 ? 7.479  -123.063 -20.713 1.00 103.64 ? 447 ASP B OD1 1 
ATOM 7005 O OD2 . ASP B 1 449 ? 7.046  -122.580 -18.589 1.00 112.70 ? 447 ASP B OD2 1 
ATOM 7006 N N   . GLU B 1 450 ? 11.179 -126.410 -19.596 1.00 104.94 ? 448 GLU B N   1 
ATOM 7007 C CA  . GLU B 1 450 ? 12.267 -127.251 -19.128 1.00 99.90  ? 448 GLU B CA  1 
ATOM 7008 C C   . GLU B 1 450 ? 13.594 -126.798 -19.742 1.00 97.55  ? 448 GLU B C   1 
ATOM 7009 O O   . GLU B 1 450 ? 14.648 -127.151 -19.226 1.00 103.71 ? 448 GLU B O   1 
ATOM 7010 C CB  . GLU B 1 450 ? 11.975 -128.731 -19.409 1.00 107.80 ? 448 GLU B CB  1 
ATOM 7011 C CG  . GLU B 1 450 ? 10.656 -129.227 -18.810 1.00 112.16 ? 448 GLU B CG  1 
ATOM 7012 C CD  . GLU B 1 450 ? 9.453  -129.194 -19.748 1.00 115.94 ? 448 GLU B CD  1 
ATOM 7013 O OE1 . GLU B 1 450 ? 8.533  -128.322 -19.702 1.00 100.55 ? 448 GLU B OE1 1 
ATOM 7014 O OE2 . GLU B 1 450 ? 9.445  -130.151 -20.550 1.00 128.78 ? 448 GLU B OE2 1 
ATOM 7015 N N   . GLU B 1 451 ? 13.550 -126.059 -20.862 1.00 98.33  ? 449 GLU B N   1 
ATOM 7016 C CA  . GLU B 1 451 ? 14.739 -125.480 -21.481 1.00 99.96  ? 449 GLU B CA  1 
ATOM 7017 C C   . GLU B 1 451 ? 15.117 -124.165 -20.789 1.00 98.56  ? 449 GLU B C   1 
ATOM 7018 O O   . GLU B 1 451 ? 16.278 -123.769 -20.822 1.00 90.03  ? 449 GLU B O   1 
ATOM 7019 C CB  . GLU B 1 451 ? 14.566 -125.177 -22.974 1.00 102.66 ? 449 GLU B CB  1 
ATOM 7020 C CG  . GLU B 1 451 ? 14.630 -126.381 -23.915 1.00 102.28 ? 449 GLU B CG  1 
ATOM 7021 C CD  . GLU B 1 451 ? 14.392 -126.074 -25.401 1.00 99.49  ? 449 GLU B CD  1 
ATOM 7022 O OE1 . GLU B 1 451 ? 13.514 -125.242 -25.749 1.00 92.66  ? 449 GLU B OE1 1 
ATOM 7023 O OE2 . GLU B 1 451 ? 15.088 -126.673 -26.255 1.00 87.12  ? 449 GLU B OE2 1 
ATOM 7024 N N   . LEU B 1 452 ? 14.126 -123.460 -20.227 1.00 101.23 ? 450 LEU B N   1 
ATOM 7025 C CA  . LEU B 1 452 ? 14.361 -122.200 -19.537 1.00 99.64  ? 450 LEU B CA  1 
ATOM 7026 C C   . LEU B 1 452 ? 14.908 -122.473 -18.136 1.00 100.48 ? 450 LEU B C   1 
ATOM 7027 O O   . LEU B 1 452 ? 15.781 -121.737 -17.683 1.00 103.58 ? 450 LEU B O   1 
ATOM 7028 C CB  . LEU B 1 452 ? 13.088 -121.354 -19.464 1.00 104.60 ? 450 LEU B CB  1 
ATOM 7029 C CG  . LEU B 1 452 ? 12.613 -120.696 -20.764 1.00 111.05 ? 450 LEU B CG  1 
ATOM 7030 C CD1 . LEU B 1 452 ? 11.146 -120.280 -20.665 1.00 112.35 ? 450 LEU B CD1 1 
ATOM 7031 C CD2 . LEU B 1 452 ? 13.466 -119.491 -21.100 1.00 118.85 ? 450 LEU B CD2 1 
ATOM 7032 N N   . ASP B 1 453 ? 14.388 -123.510 -17.455 1.00 105.59 ? 451 ASP B N   1 
ATOM 7033 C CA  . ASP B 1 453 ? 14.891 -123.941 -16.154 1.00 100.54 ? 451 ASP B CA  1 
ATOM 7034 C C   . ASP B 1 453 ? 16.406 -124.157 -16.223 1.00 103.15 ? 451 ASP B C   1 
ATOM 7035 O O   . ASP B 1 453 ? 17.107 -123.904 -15.252 1.00 101.29 ? 451 ASP B O   1 
ATOM 7036 C CB  . ASP B 1 453 ? 14.234 -125.236 -15.675 1.00 107.64 ? 451 ASP B CB  1 
ATOM 7037 C CG  . ASP B 1 453 ? 12.866 -125.188 -14.988 1.00 109.31 ? 451 ASP B CG  1 
ATOM 7038 O OD1 . ASP B 1 453 ? 11.866 -124.814 -15.631 1.00 119.37 ? 451 ASP B OD1 1 
ATOM 7039 O OD2 . ASP B 1 453 ? 12.780 -125.610 -13.817 1.00 116.18 ? 451 ASP B OD2 1 
ATOM 7040 N N   . LEU B 1 454 ? 16.897 -124.623 -17.382 1.00 104.41 ? 452 LEU B N   1 
ATOM 7041 C CA  . LEU B 1 454 ? 18.307 -124.909 -17.594 1.00 107.04 ? 452 LEU B CA  1 
ATOM 7042 C C   . LEU B 1 454 ? 19.039 -123.659 -18.078 1.00 109.70 ? 452 LEU B C   1 
ATOM 7043 O O   . LEU B 1 454 ? 20.103 -123.339 -17.557 1.00 111.63 ? 452 LEU B O   1 
ATOM 7044 C CB  . LEU B 1 454 ? 18.464 -126.045 -18.607 1.00 112.77 ? 452 LEU B CB  1 
ATOM 7045 C CG  . LEU B 1 454 ? 17.727 -127.354 -18.293 1.00 131.86 ? 452 LEU B CG  1 
ATOM 7046 C CD1 . LEU B 1 454 ? 17.768 -128.316 -19.475 1.00 121.24 ? 452 LEU B CD1 1 
ATOM 7047 C CD2 . LEU B 1 454 ? 18.267 -128.026 -17.036 1.00 145.66 ? 452 LEU B CD2 1 
ATOM 7048 N N   . ILE B 1 455 ? 18.497 -123.008 -19.121 1.00 112.27 ? 453 ILE B N   1 
ATOM 7049 C CA  . ILE B 1 455 ? 19.196 -121.970 -19.877 1.00 116.69 ? 453 ILE B CA  1 
ATOM 7050 C C   . ILE B 1 455 ? 19.277 -120.661 -19.087 1.00 111.22 ? 453 ILE B C   1 
ATOM 7051 O O   . ILE B 1 455 ? 20.311 -120.003 -19.114 1.00 101.30 ? 453 ILE B O   1 
ATOM 7052 C CB  . ILE B 1 455 ? 18.499 -121.727 -21.229 1.00 30.00  ? 453 ILE B CB  1 
ATOM 7053 C CG1 . ILE B 1 455 ? 18.617 -122.965 -22.120 1.00 30.00  ? 453 ILE B CG1 1 
ATOM 7054 C CG2 . ILE B 1 455 ? 19.090 -120.509 -21.922 1.00 30.00  ? 453 ILE B CG2 1 
ATOM 7055 C CD1 . ILE B 1 455 ? 17.744 -122.915 -23.354 1.00 30.00  ? 453 ILE B CD1 1 
ATOM 7056 N N   . LEU B 1 456 ? 18.187 -120.286 -18.397 1.00 109.09 ? 454 LEU B N   1 
ATOM 7057 C CA  . LEU B 1 456 ? 18.129 -119.059 -17.615 1.00 98.35  ? 454 LEU B CA  1 
ATOM 7058 C C   . LEU B 1 456 ? 18.495 -119.330 -16.145 1.00 107.75 ? 454 LEU B C   1 
ATOM 7059 O O   . LEU B 1 456 ? 17.936 -118.703 -15.242 1.00 105.67 ? 454 LEU B O   1 
ATOM 7060 C CB  . LEU B 1 456 ? 16.738 -118.428 -17.706 1.00 30.00  ? 454 LEU B CB  1 
ATOM 7061 C CG  . LEU B 1 456 ? 16.311 -117.923 -19.087 1.00 30.00  ? 454 LEU B CG  1 
ATOM 7062 C CD1 . LEU B 1 456 ? 14.863 -117.459 -19.064 1.00 30.00  ? 454 LEU B CD1 1 
ATOM 7063 C CD2 . LEU B 1 456 ? 17.229 -116.807 -19.559 1.00 30.00  ? 454 LEU B CD2 1 
ATOM 7064 N N   . ASP B 1 457 ? 19.435 -120.263 -15.921 1.00 108.30 ? 455 ASP B N   1 
ATOM 7065 C CA  . ASP B 1 457 ? 19.921 -120.574 -14.543 1.00 105.86 ? 455 ASP B CA  1 
ATOM 7066 C C   . ASP B 1 457 ? 21.075 -119.639 -14.191 1.00 103.75 ? 455 ASP B C   1 
ATOM 7067 O O   . ASP B 1 457 ? 22.106 -119.673 -14.888 1.00 102.98 ? 455 ASP B O   1 
ATOM 7068 C CB  . ASP B 1 457 ? 20.404 -122.004 -14.389 1.00 30.00  ? 455 ASP B CB  1 
ATOM 7069 C CG  . ASP B 1 457 ? 21.393 -122.236 -13.254 1.00 30.00  ? 455 ASP B CG  1 
ATOM 7070 O OD1 . ASP B 1 457 ? 20.985 -122.098 -12.084 1.00 30.00  ? 455 ASP B OD1 1 
ATOM 7071 O OD2 . ASP B 1 457 ? 22.565 -122.543 -13.551 1.00 30.00  ? 455 ASP B OD2 1 
ATOM 7072 N N   . PRO B 1 458 ? 20.959 -118.819 -13.132 1.00 102.75 ? 456 PRO B N   1 
ATOM 7073 C CA  . PRO B 1 458 ? 21.973 -117.812 -12.811 1.00 96.74  ? 456 PRO B CA  1 
ATOM 7074 C C   . PRO B 1 458 ? 23.437 -118.209 -12.716 1.00 103.42 ? 456 PRO B C   1 
ATOM 7075 O O   . PRO B 1 458 ? 24.287 -117.362 -12.929 1.00 114.21 ? 456 PRO B O   1 
ATOM 7076 C CB  . PRO B 1 458 ? 21.467 -117.327 -11.461 1.00 94.58  ? 456 PRO B CB  1 
ATOM 7077 C CG  . PRO B 1 458 ? 19.974 -117.283 -11.665 1.00 99.77  ? 456 PRO B CG  1 
ATOM 7078 C CD  . PRO B 1 458 ? 19.771 -118.667 -12.269 1.00 106.38 ? 456 PRO B CD  1 
ATOM 7079 N N   . TYR B 1 459 ? 23.760 -119.453 -12.350 1.00 110.99 ? 457 TYR B N   1 
ATOM 7080 C CA  . TYR B 1 459 ? 25.170 -119.776 -12.122 1.00 111.61 ? 457 TYR B CA  1 
ATOM 7081 C C   . TYR B 1 459 ? 25.849 -120.091 -13.463 1.00 105.75 ? 457 TYR B C   1 
ATOM 7082 O O   . TYR B 1 459 ? 26.412 -121.157 -13.685 1.00 78.43  ? 457 TYR B O   1 
ATOM 7083 C CB  . TYR B 1 459 ? 25.264 -120.804 -10.999 1.00 111.99 ? 457 TYR B CB  1 
ATOM 7084 C CG  . TYR B 1 459 ? 24.822 -120.198 -9.673  1.00 120.90 ? 457 TYR B CG  1 
ATOM 7085 C CD1 . TYR B 1 459 ? 23.484 -120.215 -9.278  1.00 116.99 ? 457 TYR B CD1 1 
ATOM 7086 C CD2 . TYR B 1 459 ? 25.738 -119.584 -8.823  1.00 121.85 ? 457 TYR B CD2 1 
ATOM 7087 C CE1 . TYR B 1 459 ? 23.074 -119.655 -8.079  1.00 112.45 ? 457 TYR B CE1 1 
ATOM 7088 C CE2 . TYR B 1 459 ? 25.345 -119.034 -7.610  1.00 118.58 ? 457 TYR B CE2 1 
ATOM 7089 C CZ  . TYR B 1 459 ? 24.009 -119.071 -7.244  1.00 117.15 ? 457 TYR B CZ  1 
ATOM 7090 O OH  . TYR B 1 459 ? 23.597 -118.534 -6.063  1.00 122.91 ? 457 TYR B OH  1 
ATOM 7091 N N   . GLU B 1 460 ? 25.795 -119.085 -14.328 1.00 111.08 ? 458 GLU B N   1 
ATOM 7092 C CA  . GLU B 1 460 ? 26.459 -119.196 -15.639 1.00 97.45  ? 458 GLU B CA  1 
ATOM 7093 C C   . GLU B 1 460 ? 27.728 -118.350 -15.562 1.00 103.43 ? 458 GLU B C   1 
ATOM 7094 O O   . GLU B 1 460 ? 28.460 -118.280 -16.561 1.00 107.59 ? 458 GLU B O   1 
ATOM 7095 C CB  . GLU B 1 460 ? 25.503 -118.579 -16.649 1.00 30.00  ? 458 GLU B CB  1 
ATOM 7096 C CG  . GLU B 1 460 ? 24.875 -117.279 -16.150 1.00 30.00  ? 458 GLU B CG  1 
ATOM 7097 C CD  . GLU B 1 460 ? 23.611 -116.791 -16.839 1.00 30.00  ? 458 GLU B CD  1 
ATOM 7098 O OE1 . GLU B 1 460 ? 23.729 -115.935 -17.736 1.00 30.00  ? 458 GLU B OE1 1 
ATOM 7099 O OE2 . GLU B 1 460 ? 22.508 -117.244 -16.478 1.00 30.00  ? 458 GLU B OE2 1 
ATOM 7100 N N   . MET B 1 461 ? 27.950 -117.704 -14.416 1.00 96.38  ? 459 MET B N   1 
ATOM 7101 C CA  . MET B 1 461 ? 29.160 -116.867 -14.253 1.00 83.01  ? 459 MET B CA  1 
ATOM 7102 C C   . MET B 1 461 ? 30.337 -117.755 -14.542 1.00 100.18 ? 459 MET B C   1 
ATOM 7103 O O   . MET B 1 461 ? 31.173 -117.393 -15.389 1.00 102.99 ? 459 MET B O   1 
ATOM 7104 C CB  . MET B 1 461 ? 29.371 -116.351 -12.829 1.00 30.00  ? 459 MET B CB  1 
ATOM 7105 C CG  . MET B 1 461 ? 28.986 -117.310 -11.746 1.00 30.00  ? 459 MET B CG  1 
ATOM 7106 S SD  . MET B 1 461 ? 27.195 -117.248 -11.814 1.00 30.00  ? 459 MET B SD  1 
ATOM 7107 C CE  . MET B 1 461 ? 27.050 -115.562 -12.420 1.00 30.00  ? 459 MET B CE  1 
ATOM 7108 N N   . THR B 1 462 ? 30.404 -118.910 -13.890 1.00 125.91 ? 460 THR B N   1 
ATOM 7109 C CA  . THR B 1 462 ? 31.491 -119.860 -14.182 1.00 114.96 ? 460 THR B CA  1 
ATOM 7110 C C   . THR B 1 462 ? 31.401 -120.230 -15.643 1.00 99.56  ? 460 THR B C   1 
ATOM 7111 O O   . THR B 1 462 ? 30.419 -120.899 -16.022 1.00 97.33  ? 460 THR B O   1 
ATOM 7112 C CB  . THR B 1 462 ? 31.384 -121.079 -13.267 1.00 30.00  ? 460 THR B CB  1 
ATOM 7113 O OG1 . THR B 1 462 ? 30.529 -120.711 -12.189 1.00 30.00  ? 460 THR B OG1 1 
ATOM 7114 C CG2 . THR B 1 462 ? 32.732 -121.507 -12.716 1.00 30.00  ? 460 THR B CG2 1 
ATOM 7115 N N   . HIS B 1 463 ? 32.378 -119.801 -16.440 1.00 89.20  ? 461 HIS B N   1 
ATOM 7116 C CA  . HIS B 1 463 ? 32.404 -120.156 -17.881 1.00 92.79  ? 461 HIS B CA  1 
ATOM 7117 C C   . HIS B 1 463 ? 33.838 -120.046 -18.400 1.00 78.29  ? 461 HIS B C   1 
ATOM 7118 O O   . HIS B 1 463 ? 33.993 -120.151 -19.631 1.00 81.02  ? 461 HIS B O   1 
ATOM 7119 C CB  . HIS B 1 463 ? 31.449 -119.260 -18.671 1.00 30.00  ? 461 HIS B CB  1 
ATOM 7120 C CG  . HIS B 1 463 ? 30.721 -119.970 -19.764 1.00 30.00  ? 461 HIS B CG  1 
ATOM 7121 N ND1 . HIS B 1 463 ? 29.372 -120.245 -19.709 1.00 30.00  ? 461 HIS B ND1 1 
ATOM 7122 C CD2 . HIS B 1 463 ? 31.148 -120.459 -20.936 1.00 30.00  ? 461 HIS B CD2 1 
ATOM 7123 C CE1 . HIS B 1 463 ? 29.009 -120.877 -20.816 1.00 30.00  ? 461 HIS B CE1 1 
ATOM 7124 N NE2 . HIS B 1 463 ? 30.072 -121.017 -21.575 1.00 30.00  ? 461 HIS B NE2 1 
# 
