data_8RGU
# 
_entry.id   8RGU 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8RGU         pdb_00008rgu 10.2210/pdb8rgu/pdb 
WWPDB D_1292135367 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2024-12-04 
2 'Structure model' 1 1 2024-12-25 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation_author.identifier_ORCID' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8RGU 
_pdbx_database_status.recvd_initial_deposition_date   2023-12-14 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              jens.petersen@astrazeneca.com 
_pdbx_contact_author.name_first         Jens 
_pdbx_contact_author.name_last          Petersen 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-5946-4756 
# 
_audit_author.name               'Petersen, J.' 
_audit_author.pdbx_ordinal       1 
_audit_author.identifier_ORCID   ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            J.Med.Chem. 
_citation.journal_id_ASTM           JMCMAR 
_citation.journal_id_CSD            0151 
_citation.journal_id_ISSN           0022-2623 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            67 
_citation.language                  ? 
_citation.page_first                20827 
_citation.page_last                 20841 
_citation.title                     
;Discovery of (2 R ,4 R )-4-(( S )-2-Amino-3-methylbutanamido)-2-(4-boronobutyl)pyrrolidine-2-carboxylic Acid (AZD0011), an Actively Transported Prodrug of a Potent Arginase Inhibitor to Treat Cancer.
;
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/acs.jmedchem.4c02309 
_citation.pdbx_database_id_PubMed   39572889 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Mlynarski, S.N.' 1  ? 
primary 'Aquila, B.M.'    2  ? 
primary 'Cantin, S.'      3  ? 
primary 'Cook, S.'        4  ? 
primary 'Doshi, A.'       5  ? 
primary 'Finlay, M.R.V.'  6  ? 
primary 'Gangl, E.T.'     7  ? 
primary 'Grebe, T.'       8  ? 
primary 'Gu, C.'          9  ? 
primary 'Kawatkar, S.P.'  10 ? 
primary 'Petersen, J.'    11 ? 
primary 'Pop-Damkov, P.'  12 ? 
primary 'Schuller, A.G.'  13 ? 
primary 'Shao, W.'        14 ? 
primary 'Shields, J.D.'   15 ? 
primary 'Simpson, I.'     16 ? 
primary 'Tavakoli, S.'    17 ? 
primary 'Tentarelli, S.'  18 ? 
primary 'Throner, S.'     19 ? 
primary 'Wang, H.'        20 ? 
primary 'Wang, J.'        21 ? 
primary 'Wu, D.'          22 ? 
primary 'Ye, Q.'          23 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Arginase-2, mitochondrial' 36653.367 3   3.5.3.1 ? ? ? 
2 non-polymer syn 'MANGANESE (II) ION'        54.938    6   ?       ? ? ? 
3 non-polymer syn 'DIMETHYL SULFOXIDE'        78.133    6   ?       ? ? ? 
4 non-polymer nat PROLINE                     115.130   3   ?       ? ? ? 
5 water       nat water                       18.015    378 ?       ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Arginase II,Kidney-type arginase,Non-hepatic arginase,Type II arginase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MHHHHHHGGGENLYFQSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNL
IVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVS
FLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRP
IHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQ
TREGGHIVYDQLPTPS
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MHHHHHHGGGENLYFQSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNL
IVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVS
FLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRP
IHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQ
TREGGHIVYDQLPTPS
;
_entity_poly.pdbx_strand_id                 A,B,C 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'MANGANESE (II) ION' MN  
3 'DIMETHYL SULFOXIDE' DMS 
4 PROLINE              PRO 
5 water                HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   HIS n 
1 3   HIS n 
1 4   HIS n 
1 5   HIS n 
1 6   HIS n 
1 7   HIS n 
1 8   GLY n 
1 9   GLY n 
1 10  GLY n 
1 11  GLU n 
1 12  ASN n 
1 13  LEU n 
1 14  TYR n 
1 15  PHE n 
1 16  GLN n 
1 17  SER n 
1 18  VAL n 
1 19  HIS n 
1 20  SER n 
1 21  VAL n 
1 22  ALA n 
1 23  VAL n 
1 24  ILE n 
1 25  GLY n 
1 26  ALA n 
1 27  PRO n 
1 28  PHE n 
1 29  SER n 
1 30  GLN n 
1 31  GLY n 
1 32  GLN n 
1 33  LYS n 
1 34  ARG n 
1 35  LYS n 
1 36  GLY n 
1 37  VAL n 
1 38  GLU n 
1 39  HIS n 
1 40  GLY n 
1 41  PRO n 
1 42  ALA n 
1 43  ALA n 
1 44  ILE n 
1 45  ARG n 
1 46  GLU n 
1 47  ALA n 
1 48  GLY n 
1 49  LEU n 
1 50  MET n 
1 51  LYS n 
1 52  ARG n 
1 53  LEU n 
1 54  SER n 
1 55  SER n 
1 56  LEU n 
1 57  GLY n 
1 58  CYS n 
1 59  HIS n 
1 60  LEU n 
1 61  LYS n 
1 62  ASP n 
1 63  PHE n 
1 64  GLY n 
1 65  ASP n 
1 66  LEU n 
1 67  SER n 
1 68  PHE n 
1 69  THR n 
1 70  PRO n 
1 71  VAL n 
1 72  PRO n 
1 73  LYS n 
1 74  ASP n 
1 75  ASP n 
1 76  LEU n 
1 77  TYR n 
1 78  ASN n 
1 79  ASN n 
1 80  LEU n 
1 81  ILE n 
1 82  VAL n 
1 83  ASN n 
1 84  PRO n 
1 85  ARG n 
1 86  SER n 
1 87  VAL n 
1 88  GLY n 
1 89  LEU n 
1 90  ALA n 
1 91  ASN n 
1 92  GLN n 
1 93  GLU n 
1 94  LEU n 
1 95  ALA n 
1 96  GLU n 
1 97  VAL n 
1 98  VAL n 
1 99  SER n 
1 100 ARG n 
1 101 ALA n 
1 102 VAL n 
1 103 SER n 
1 104 ASP n 
1 105 GLY n 
1 106 TYR n 
1 107 SER n 
1 108 CYS n 
1 109 VAL n 
1 110 THR n 
1 111 LEU n 
1 112 GLY n 
1 113 GLY n 
1 114 ASP n 
1 115 HIS n 
1 116 SER n 
1 117 LEU n 
1 118 ALA n 
1 119 ILE n 
1 120 GLY n 
1 121 THR n 
1 122 ILE n 
1 123 SER n 
1 124 GLY n 
1 125 HIS n 
1 126 ALA n 
1 127 ARG n 
1 128 HIS n 
1 129 CYS n 
1 130 PRO n 
1 131 ASP n 
1 132 LEU n 
1 133 CYS n 
1 134 VAL n 
1 135 VAL n 
1 136 TRP n 
1 137 VAL n 
1 138 ASP n 
1 139 ALA n 
1 140 HIS n 
1 141 ALA n 
1 142 ASP n 
1 143 ILE n 
1 144 ASN n 
1 145 THR n 
1 146 PRO n 
1 147 LEU n 
1 148 THR n 
1 149 THR n 
1 150 SER n 
1 151 SER n 
1 152 GLY n 
1 153 ASN n 
1 154 LEU n 
1 155 HIS n 
1 156 GLY n 
1 157 GLN n 
1 158 PRO n 
1 159 VAL n 
1 160 SER n 
1 161 PHE n 
1 162 LEU n 
1 163 LEU n 
1 164 ARG n 
1 165 GLU n 
1 166 LEU n 
1 167 GLN n 
1 168 ASP n 
1 169 LYS n 
1 170 VAL n 
1 171 PRO n 
1 172 GLN n 
1 173 LEU n 
1 174 PRO n 
1 175 GLY n 
1 176 PHE n 
1 177 SER n 
1 178 TRP n 
1 179 ILE n 
1 180 LYS n 
1 181 PRO n 
1 182 CYS n 
1 183 ILE n 
1 184 SER n 
1 185 SER n 
1 186 ALA n 
1 187 SER n 
1 188 ILE n 
1 189 VAL n 
1 190 TYR n 
1 191 ILE n 
1 192 GLY n 
1 193 LEU n 
1 194 ARG n 
1 195 ASP n 
1 196 VAL n 
1 197 ASP n 
1 198 PRO n 
1 199 PRO n 
1 200 GLU n 
1 201 HIS n 
1 202 PHE n 
1 203 ILE n 
1 204 LEU n 
1 205 LYS n 
1 206 ASN n 
1 207 TYR n 
1 208 ASP n 
1 209 ILE n 
1 210 GLN n 
1 211 TYR n 
1 212 PHE n 
1 213 SER n 
1 214 MET n 
1 215 ARG n 
1 216 ASP n 
1 217 ILE n 
1 218 ASP n 
1 219 ARG n 
1 220 LEU n 
1 221 GLY n 
1 222 ILE n 
1 223 GLN n 
1 224 LYS n 
1 225 VAL n 
1 226 MET n 
1 227 GLU n 
1 228 ARG n 
1 229 THR n 
1 230 PHE n 
1 231 ASP n 
1 232 LEU n 
1 233 LEU n 
1 234 ILE n 
1 235 GLY n 
1 236 LYS n 
1 237 ARG n 
1 238 GLN n 
1 239 ARG n 
1 240 PRO n 
1 241 ILE n 
1 242 HIS n 
1 243 LEU n 
1 244 SER n 
1 245 PHE n 
1 246 ASP n 
1 247 ILE n 
1 248 ASP n 
1 249 ALA n 
1 250 PHE n 
1 251 ASP n 
1 252 PRO n 
1 253 THR n 
1 254 LEU n 
1 255 ALA n 
1 256 PRO n 
1 257 ALA n 
1 258 THR n 
1 259 GLY n 
1 260 THR n 
1 261 PRO n 
1 262 VAL n 
1 263 VAL n 
1 264 GLY n 
1 265 GLY n 
1 266 LEU n 
1 267 THR n 
1 268 TYR n 
1 269 ARG n 
1 270 GLU n 
1 271 GLY n 
1 272 MET n 
1 273 TYR n 
1 274 ILE n 
1 275 ALA n 
1 276 GLU n 
1 277 GLU n 
1 278 ILE n 
1 279 HIS n 
1 280 ASN n 
1 281 THR n 
1 282 GLY n 
1 283 LEU n 
1 284 LEU n 
1 285 SER n 
1 286 ALA n 
1 287 LEU n 
1 288 ASP n 
1 289 LEU n 
1 290 VAL n 
1 291 GLU n 
1 292 VAL n 
1 293 ASN n 
1 294 PRO n 
1 295 GLN n 
1 296 LEU n 
1 297 ALA n 
1 298 THR n 
1 299 SER n 
1 300 GLU n 
1 301 GLU n 
1 302 GLU n 
1 303 ALA n 
1 304 LYS n 
1 305 THR n 
1 306 THR n 
1 307 ALA n 
1 308 ASN n 
1 309 LEU n 
1 310 ALA n 
1 311 VAL n 
1 312 ASP n 
1 313 VAL n 
1 314 ILE n 
1 315 ALA n 
1 316 SER n 
1 317 SER n 
1 318 PHE n 
1 319 GLY n 
1 320 GLN n 
1 321 THR n 
1 322 ARG n 
1 323 GLU n 
1 324 GLY n 
1 325 GLY n 
1 326 HIS n 
1 327 ILE n 
1 328 VAL n 
1 329 TYR n 
1 330 ASP n 
1 331 GLN n 
1 332 LEU n 
1 333 PRO n 
1 334 THR n 
1 335 PRO n 
1 336 SER n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   336 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ARG2 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE              ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE             ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE           ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'      ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE             ? 'C3 H7 N O2 S'   121.158 
DMS non-polymer         . 'DIMETHYL SULFOXIDE' ? 'C2 H6 O S'      78.133  
GLN 'L-peptide linking' y GLUTAMINE            ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'      ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE              ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE            ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE           ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE              ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE               ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE           ? 'C5 H11 N O2 S'  149.211 
MN  non-polymer         . 'MANGANESE (II) ION' ? 'Mn 2'           54.938  
PHE 'L-peptide linking' y PHENYLALANINE        ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE              ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE               ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE            ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN           ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE             ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE               ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   6   ?   ?   ?   A . n 
A 1 2   HIS 2   7   ?   ?   ?   A . n 
A 1 3   HIS 3   8   ?   ?   ?   A . n 
A 1 4   HIS 4   9   ?   ?   ?   A . n 
A 1 5   HIS 5   10  ?   ?   ?   A . n 
A 1 6   HIS 6   11  ?   ?   ?   A . n 
A 1 7   HIS 7   12  ?   ?   ?   A . n 
A 1 8   GLY 8   13  ?   ?   ?   A . n 
A 1 9   GLY 9   14  ?   ?   ?   A . n 
A 1 10  GLY 10  15  ?   ?   ?   A . n 
A 1 11  GLU 11  16  ?   ?   ?   A . n 
A 1 12  ASN 12  17  17  ASN ASN A . n 
A 1 13  LEU 13  18  18  LEU LEU A . n 
A 1 14  TYR 14  19  19  TYR TYR A . n 
A 1 15  PHE 15  20  20  PHE PHE A . n 
A 1 16  GLN 16  21  21  GLN GLN A . n 
A 1 17  SER 17  22  22  SER SER A . n 
A 1 18  VAL 18  23  23  VAL VAL A . n 
A 1 19  HIS 19  24  24  HIS HIS A . n 
A 1 20  SER 20  25  25  SER SER A . n 
A 1 21  VAL 21  26  26  VAL VAL A . n 
A 1 22  ALA 22  27  27  ALA ALA A . n 
A 1 23  VAL 23  28  28  VAL VAL A . n 
A 1 24  ILE 24  29  29  ILE ILE A . n 
A 1 25  GLY 25  30  30  GLY GLY A . n 
A 1 26  ALA 26  31  31  ALA ALA A . n 
A 1 27  PRO 27  32  32  PRO PRO A . n 
A 1 28  PHE 28  33  33  PHE PHE A . n 
A 1 29  SER 29  34  34  SER SER A . n 
A 1 30  GLN 30  35  35  GLN GLN A . n 
A 1 31  GLY 31  36  36  GLY GLY A . n 
A 1 32  GLN 32  37  37  GLN GLN A . n 
A 1 33  LYS 33  38  38  LYS LYS A . n 
A 1 34  ARG 34  39  39  ARG ARG A . n 
A 1 35  LYS 35  40  40  LYS LYS A . n 
A 1 36  GLY 36  41  41  GLY GLY A . n 
A 1 37  VAL 37  42  42  VAL VAL A . n 
A 1 38  GLU 38  43  43  GLU GLU A . n 
A 1 39  HIS 39  44  44  HIS HIS A . n 
A 1 40  GLY 40  45  45  GLY GLY A . n 
A 1 41  PRO 41  46  46  PRO PRO A . n 
A 1 42  ALA 42  47  47  ALA ALA A . n 
A 1 43  ALA 43  48  48  ALA ALA A . n 
A 1 44  ILE 44  49  49  ILE ILE A . n 
A 1 45  ARG 45  50  50  ARG ARG A . n 
A 1 46  GLU 46  51  51  GLU GLU A . n 
A 1 47  ALA 47  52  52  ALA ALA A . n 
A 1 48  GLY 48  53  53  GLY GLY A . n 
A 1 49  LEU 49  54  54  LEU LEU A . n 
A 1 50  MET 50  55  55  MET MET A . n 
A 1 51  LYS 51  56  56  LYS LYS A . n 
A 1 52  ARG 52  57  57  ARG ARG A . n 
A 1 53  LEU 53  58  58  LEU LEU A . n 
A 1 54  SER 54  59  59  SER SER A . n 
A 1 55  SER 55  60  60  SER SER A . n 
A 1 56  LEU 56  61  61  LEU LEU A . n 
A 1 57  GLY 57  62  62  GLY GLY A . n 
A 1 58  CYS 58  63  63  CYS CYS A . n 
A 1 59  HIS 59  64  64  HIS HIS A . n 
A 1 60  LEU 60  65  65  LEU LEU A . n 
A 1 61  LYS 61  66  66  LYS LYS A . n 
A 1 62  ASP 62  67  67  ASP ASP A . n 
A 1 63  PHE 63  68  68  PHE PHE A . n 
A 1 64  GLY 64  69  69  GLY GLY A . n 
A 1 65  ASP 65  70  70  ASP ASP A . n 
A 1 66  LEU 66  71  71  LEU LEU A . n 
A 1 67  SER 67  72  72  SER SER A . n 
A 1 68  PHE 68  73  ?   ?   ?   A . n 
A 1 69  THR 69  74  ?   ?   ?   A . n 
A 1 70  PRO 70  75  ?   ?   ?   A . n 
A 1 71  VAL 71  76  ?   ?   ?   A . n 
A 1 72  PRO 72  77  ?   ?   ?   A . n 
A 1 73  LYS 73  78  ?   ?   ?   A . n 
A 1 74  ASP 74  79  79  ASP ASP A . n 
A 1 75  ASP 75  80  80  ASP ASP A . n 
A 1 76  LEU 76  81  81  LEU LEU A . n 
A 1 77  TYR 77  82  82  TYR TYR A . n 
A 1 78  ASN 78  83  83  ASN ASN A . n 
A 1 79  ASN 79  84  84  ASN ASN A . n 
A 1 80  LEU 80  85  85  LEU LEU A . n 
A 1 81  ILE 81  86  86  ILE ILE A . n 
A 1 82  VAL 82  87  87  VAL VAL A . n 
A 1 83  ASN 83  88  88  ASN ASN A . n 
A 1 84  PRO 84  89  89  PRO PRO A . n 
A 1 85  ARG 85  90  90  ARG ARG A . n 
A 1 86  SER 86  91  91  SER SER A . n 
A 1 87  VAL 87  92  92  VAL VAL A . n 
A 1 88  GLY 88  93  93  GLY GLY A . n 
A 1 89  LEU 89  94  94  LEU LEU A . n 
A 1 90  ALA 90  95  95  ALA ALA A . n 
A 1 91  ASN 91  96  96  ASN ASN A . n 
A 1 92  GLN 92  97  97  GLN GLN A . n 
A 1 93  GLU 93  98  98  GLU GLU A . n 
A 1 94  LEU 94  99  99  LEU LEU A . n 
A 1 95  ALA 95  100 100 ALA ALA A . n 
A 1 96  GLU 96  101 101 GLU GLU A . n 
A 1 97  VAL 97  102 102 VAL VAL A . n 
A 1 98  VAL 98  103 103 VAL VAL A . n 
A 1 99  SER 99  104 104 SER SER A . n 
A 1 100 ARG 100 105 105 ARG ARG A . n 
A 1 101 ALA 101 106 106 ALA ALA A . n 
A 1 102 VAL 102 107 107 VAL VAL A . n 
A 1 103 SER 103 108 108 SER SER A . n 
A 1 104 ASP 104 109 109 ASP ASP A . n 
A 1 105 GLY 105 110 110 GLY GLY A . n 
A 1 106 TYR 106 111 111 TYR TYR A . n 
A 1 107 SER 107 112 112 SER SER A . n 
A 1 108 CYS 108 113 113 CYS CYS A . n 
A 1 109 VAL 109 114 114 VAL VAL A . n 
A 1 110 THR 110 115 115 THR THR A . n 
A 1 111 LEU 111 116 116 LEU LEU A . n 
A 1 112 GLY 112 117 117 GLY GLY A . n 
A 1 113 GLY 113 118 118 GLY GLY A . n 
A 1 114 ASP 114 119 119 ASP ASP A . n 
A 1 115 HIS 115 120 120 HIS HIS A . n 
A 1 116 SER 116 121 121 SER SER A . n 
A 1 117 LEU 117 122 122 LEU LEU A . n 
A 1 118 ALA 118 123 123 ALA ALA A . n 
A 1 119 ILE 119 124 124 ILE ILE A . n 
A 1 120 GLY 120 125 125 GLY GLY A . n 
A 1 121 THR 121 126 126 THR THR A . n 
A 1 122 ILE 122 127 127 ILE ILE A . n 
A 1 123 SER 123 128 128 SER SER A . n 
A 1 124 GLY 124 129 129 GLY GLY A . n 
A 1 125 HIS 125 130 130 HIS HIS A . n 
A 1 126 ALA 126 131 131 ALA ALA A . n 
A 1 127 ARG 127 132 132 ARG ARG A . n 
A 1 128 HIS 128 133 133 HIS HIS A . n 
A 1 129 CYS 129 134 134 CYS CYS A . n 
A 1 130 PRO 130 135 135 PRO PRO A . n 
A 1 131 ASP 131 136 136 ASP ASP A . n 
A 1 132 LEU 132 137 137 LEU LEU A . n 
A 1 133 CYS 133 138 138 CYS CYS A . n 
A 1 134 VAL 134 139 139 VAL VAL A . n 
A 1 135 VAL 135 140 140 VAL VAL A . n 
A 1 136 TRP 136 141 141 TRP TRP A . n 
A 1 137 VAL 137 142 142 VAL VAL A . n 
A 1 138 ASP 138 143 143 ASP ASP A . n 
A 1 139 ALA 139 144 144 ALA ALA A . n 
A 1 140 HIS 140 145 145 HIS HIS A . n 
A 1 141 ALA 141 146 146 ALA ALA A . n 
A 1 142 ASP 142 147 147 ASP ASP A . n 
A 1 143 ILE 143 148 148 ILE ILE A . n 
A 1 144 ASN 144 149 149 ASN ASN A . n 
A 1 145 THR 145 150 150 THR THR A . n 
A 1 146 PRO 146 151 151 PRO PRO A . n 
A 1 147 LEU 147 152 152 LEU LEU A . n 
A 1 148 THR 148 153 153 THR THR A . n 
A 1 149 THR 149 154 154 THR THR A . n 
A 1 150 SER 150 155 155 SER SER A . n 
A 1 151 SER 151 156 156 SER SER A . n 
A 1 152 GLY 152 157 157 GLY GLY A . n 
A 1 153 ASN 153 158 158 ASN ASN A . n 
A 1 154 LEU 154 159 159 LEU LEU A . n 
A 1 155 HIS 155 160 160 HIS HIS A . n 
A 1 156 GLY 156 161 161 GLY GLY A . n 
A 1 157 GLN 157 162 162 GLN GLN A . n 
A 1 158 PRO 158 163 163 PRO PRO A . n 
A 1 159 VAL 159 164 164 VAL VAL A . n 
A 1 160 SER 160 165 165 SER SER A . n 
A 1 161 PHE 161 166 166 PHE PHE A . n 
A 1 162 LEU 162 167 167 LEU LEU A . n 
A 1 163 LEU 163 168 168 LEU LEU A . n 
A 1 164 ARG 164 169 169 ARG ARG A . n 
A 1 165 GLU 165 170 170 GLU GLU A . n 
A 1 166 LEU 166 171 171 LEU LEU A . n 
A 1 167 GLN 167 172 172 GLN GLN A . n 
A 1 168 ASP 168 173 173 ASP ASP A . n 
A 1 169 LYS 169 174 174 LYS LYS A . n 
A 1 170 VAL 170 175 175 VAL VAL A . n 
A 1 171 PRO 171 176 176 PRO PRO A . n 
A 1 172 GLN 172 177 177 GLN GLN A . n 
A 1 173 LEU 173 178 178 LEU LEU A . n 
A 1 174 PRO 174 179 179 PRO PRO A . n 
A 1 175 GLY 175 180 180 GLY GLY A . n 
A 1 176 PHE 176 181 181 PHE PHE A . n 
A 1 177 SER 177 182 182 SER SER A . n 
A 1 178 TRP 178 183 183 TRP TRP A . n 
A 1 179 ILE 179 184 184 ILE ILE A . n 
A 1 180 LYS 180 185 185 LYS LYS A . n 
A 1 181 PRO 181 186 186 PRO PRO A . n 
A 1 182 CYS 182 187 187 CYS CYS A . n 
A 1 183 ILE 183 188 188 ILE ILE A . n 
A 1 184 SER 184 189 189 SER SER A . n 
A 1 185 SER 185 190 190 SER SER A . n 
A 1 186 ALA 186 191 191 ALA ALA A . n 
A 1 187 SER 187 192 192 SER SER A . n 
A 1 188 ILE 188 193 193 ILE ILE A . n 
A 1 189 VAL 189 194 194 VAL VAL A . n 
A 1 190 TYR 190 195 195 TYR TYR A . n 
A 1 191 ILE 191 196 196 ILE ILE A . n 
A 1 192 GLY 192 197 197 GLY GLY A . n 
A 1 193 LEU 193 198 198 LEU LEU A . n 
A 1 194 ARG 194 199 199 ARG ARG A . n 
A 1 195 ASP 195 200 200 ASP ASP A . n 
A 1 196 VAL 196 201 201 VAL VAL A . n 
A 1 197 ASP 197 202 202 ASP ASP A . n 
A 1 198 PRO 198 203 203 PRO PRO A . n 
A 1 199 PRO 199 204 204 PRO PRO A . n 
A 1 200 GLU 200 205 205 GLU GLU A . n 
A 1 201 HIS 201 206 206 HIS HIS A . n 
A 1 202 PHE 202 207 207 PHE PHE A . n 
A 1 203 ILE 203 208 208 ILE ILE A . n 
A 1 204 LEU 204 209 209 LEU LEU A . n 
A 1 205 LYS 205 210 210 LYS LYS A . n 
A 1 206 ASN 206 211 211 ASN ASN A . n 
A 1 207 TYR 207 212 212 TYR TYR A . n 
A 1 208 ASP 208 213 213 ASP ASP A . n 
A 1 209 ILE 209 214 214 ILE ILE A . n 
A 1 210 GLN 210 215 215 GLN GLN A . n 
A 1 211 TYR 211 216 216 TYR TYR A . n 
A 1 212 PHE 212 217 217 PHE PHE A . n 
A 1 213 SER 213 218 218 SER SER A . n 
A 1 214 MET 214 219 219 MET MET A . n 
A 1 215 ARG 215 220 220 ARG ARG A . n 
A 1 216 ASP 216 221 221 ASP ASP A . n 
A 1 217 ILE 217 222 222 ILE ILE A . n 
A 1 218 ASP 218 223 223 ASP ASP A . n 
A 1 219 ARG 219 224 224 ARG ARG A . n 
A 1 220 LEU 220 225 225 LEU LEU A . n 
A 1 221 GLY 221 226 226 GLY GLY A . n 
A 1 222 ILE 222 227 227 ILE ILE A . n 
A 1 223 GLN 223 228 228 GLN GLN A . n 
A 1 224 LYS 224 229 229 LYS LYS A . n 
A 1 225 VAL 225 230 230 VAL VAL A . n 
A 1 226 MET 226 231 231 MET MET A . n 
A 1 227 GLU 227 232 232 GLU GLU A . n 
A 1 228 ARG 228 233 233 ARG ARG A . n 
A 1 229 THR 229 234 234 THR THR A . n 
A 1 230 PHE 230 235 235 PHE PHE A . n 
A 1 231 ASP 231 236 236 ASP ASP A . n 
A 1 232 LEU 232 237 237 LEU LEU A . n 
A 1 233 LEU 233 238 238 LEU LEU A . n 
A 1 234 ILE 234 239 239 ILE ILE A . n 
A 1 235 GLY 235 240 240 GLY GLY A . n 
A 1 236 LYS 236 241 241 LYS LYS A . n 
A 1 237 ARG 237 242 242 ARG ARG A . n 
A 1 238 GLN 238 243 243 GLN GLN A . n 
A 1 239 ARG 239 244 244 ARG ARG A . n 
A 1 240 PRO 240 245 245 PRO PRO A . n 
A 1 241 ILE 241 246 246 ILE ILE A . n 
A 1 242 HIS 242 247 247 HIS HIS A . n 
A 1 243 LEU 243 248 248 LEU LEU A . n 
A 1 244 SER 244 249 249 SER SER A . n 
A 1 245 PHE 245 250 250 PHE PHE A . n 
A 1 246 ASP 246 251 251 ASP ASP A . n 
A 1 247 ILE 247 252 252 ILE ILE A . n 
A 1 248 ASP 248 253 253 ASP ASP A . n 
A 1 249 ALA 249 254 254 ALA ALA A . n 
A 1 250 PHE 250 255 255 PHE PHE A . n 
A 1 251 ASP 251 256 256 ASP ASP A . n 
A 1 252 PRO 252 257 257 PRO PRO A . n 
A 1 253 THR 253 258 258 THR THR A . n 
A 1 254 LEU 254 259 259 LEU LEU A . n 
A 1 255 ALA 255 260 260 ALA ALA A . n 
A 1 256 PRO 256 261 261 PRO PRO A . n 
A 1 257 ALA 257 262 262 ALA ALA A . n 
A 1 258 THR 258 263 263 THR THR A . n 
A 1 259 GLY 259 264 264 GLY GLY A . n 
A 1 260 THR 260 265 265 THR THR A . n 
A 1 261 PRO 261 266 266 PRO PRO A . n 
A 1 262 VAL 262 267 267 VAL VAL A . n 
A 1 263 VAL 263 268 268 VAL VAL A . n 
A 1 264 GLY 264 269 269 GLY GLY A . n 
A 1 265 GLY 265 270 270 GLY GLY A . n 
A 1 266 LEU 266 271 271 LEU LEU A . n 
A 1 267 THR 267 272 272 THR THR A . n 
A 1 268 TYR 268 273 273 TYR TYR A . n 
A 1 269 ARG 269 274 274 ARG ARG A . n 
A 1 270 GLU 270 275 275 GLU GLU A . n 
A 1 271 GLY 271 276 276 GLY GLY A . n 
A 1 272 MET 272 277 277 MET MET A . n 
A 1 273 TYR 273 278 278 TYR TYR A . n 
A 1 274 ILE 274 279 279 ILE ILE A . n 
A 1 275 ALA 275 280 280 ALA ALA A . n 
A 1 276 GLU 276 281 281 GLU GLU A . n 
A 1 277 GLU 277 282 282 GLU GLU A . n 
A 1 278 ILE 278 283 283 ILE ILE A . n 
A 1 279 HIS 279 284 284 HIS HIS A . n 
A 1 280 ASN 280 285 285 ASN ASN A . n 
A 1 281 THR 281 286 286 THR THR A . n 
A 1 282 GLY 282 287 287 GLY GLY A . n 
A 1 283 LEU 283 288 288 LEU LEU A . n 
A 1 284 LEU 284 289 289 LEU LEU A . n 
A 1 285 SER 285 290 290 SER SER A . n 
A 1 286 ALA 286 291 291 ALA ALA A . n 
A 1 287 LEU 287 292 292 LEU LEU A . n 
A 1 288 ASP 288 293 293 ASP ASP A . n 
A 1 289 LEU 289 294 294 LEU LEU A . n 
A 1 290 VAL 290 295 295 VAL VAL A . n 
A 1 291 GLU 291 296 296 GLU GLU A . n 
A 1 292 VAL 292 297 297 VAL VAL A . n 
A 1 293 ASN 293 298 298 ASN ASN A . n 
A 1 294 PRO 294 299 299 PRO PRO A . n 
A 1 295 GLN 295 300 300 GLN GLN A . n 
A 1 296 LEU 296 301 301 LEU LEU A . n 
A 1 297 ALA 297 302 302 ALA ALA A . n 
A 1 298 THR 298 303 303 THR THR A . n 
A 1 299 SER 299 304 304 SER SER A . n 
A 1 300 GLU 300 305 305 GLU GLU A . n 
A 1 301 GLU 301 306 306 GLU GLU A . n 
A 1 302 GLU 302 307 307 GLU GLU A . n 
A 1 303 ALA 303 308 308 ALA ALA A . n 
A 1 304 LYS 304 309 309 LYS LYS A . n 
A 1 305 THR 305 310 310 THR THR A . n 
A 1 306 THR 306 311 311 THR THR A . n 
A 1 307 ALA 307 312 312 ALA ALA A . n 
A 1 308 ASN 308 313 313 ASN ASN A . n 
A 1 309 LEU 309 314 314 LEU LEU A . n 
A 1 310 ALA 310 315 315 ALA ALA A . n 
A 1 311 VAL 311 316 316 VAL VAL A . n 
A 1 312 ASP 312 317 317 ASP ASP A . n 
A 1 313 VAL 313 318 318 VAL VAL A . n 
A 1 314 ILE 314 319 319 ILE ILE A . n 
A 1 315 ALA 315 320 320 ALA ALA A . n 
A 1 316 SER 316 321 321 SER SER A . n 
A 1 317 SER 317 322 322 SER SER A . n 
A 1 318 PHE 318 323 323 PHE PHE A . n 
A 1 319 GLY 319 324 324 GLY GLY A . n 
A 1 320 GLN 320 325 325 GLN GLN A . n 
A 1 321 THR 321 326 326 THR THR A . n 
A 1 322 ARG 322 327 327 ARG ARG A . n 
A 1 323 GLU 323 328 328 GLU GLU A . n 
A 1 324 GLY 324 329 329 GLY GLY A . n 
A 1 325 GLY 325 330 330 GLY GLY A . n 
A 1 326 HIS 326 331 331 HIS HIS A . n 
A 1 327 ILE 327 332 332 ILE ILE A . n 
A 1 328 VAL 328 333 333 VAL VAL A . n 
A 1 329 TYR 329 334 334 TYR TYR A . n 
A 1 330 ASP 330 335 335 ASP ASP A . n 
A 1 331 GLN 331 336 336 GLN GLN A . n 
A 1 332 LEU 332 337 337 LEU LEU A . n 
A 1 333 PRO 333 338 338 PRO PRO A . n 
A 1 334 THR 334 339 339 THR THR A . n 
A 1 335 PRO 335 340 340 PRO PRO A . n 
A 1 336 SER 336 341 ?   ?   ?   A . n 
B 1 1   MET 1   6   ?   ?   ?   B . n 
B 1 2   HIS 2   7   ?   ?   ?   B . n 
B 1 3   HIS 3   8   ?   ?   ?   B . n 
B 1 4   HIS 4   9   ?   ?   ?   B . n 
B 1 5   HIS 5   10  ?   ?   ?   B . n 
B 1 6   HIS 6   11  ?   ?   ?   B . n 
B 1 7   HIS 7   12  ?   ?   ?   B . n 
B 1 8   GLY 8   13  ?   ?   ?   B . n 
B 1 9   GLY 9   14  ?   ?   ?   B . n 
B 1 10  GLY 10  15  ?   ?   ?   B . n 
B 1 11  GLU 11  16  ?   ?   ?   B . n 
B 1 12  ASN 12  17  ?   ?   ?   B . n 
B 1 13  LEU 13  18  ?   ?   ?   B . n 
B 1 14  TYR 14  19  ?   ?   ?   B . n 
B 1 15  PHE 15  20  ?   ?   ?   B . n 
B 1 16  GLN 16  21  ?   ?   ?   B . n 
B 1 17  SER 17  22  ?   ?   ?   B . n 
B 1 18  VAL 18  23  23  VAL VAL B . n 
B 1 19  HIS 19  24  24  HIS HIS B . n 
B 1 20  SER 20  25  25  SER SER B . n 
B 1 21  VAL 21  26  26  VAL VAL B . n 
B 1 22  ALA 22  27  27  ALA ALA B . n 
B 1 23  VAL 23  28  28  VAL VAL B . n 
B 1 24  ILE 24  29  29  ILE ILE B . n 
B 1 25  GLY 25  30  30  GLY GLY B . n 
B 1 26  ALA 26  31  31  ALA ALA B . n 
B 1 27  PRO 27  32  32  PRO PRO B . n 
B 1 28  PHE 28  33  33  PHE PHE B . n 
B 1 29  SER 29  34  34  SER SER B . n 
B 1 30  GLN 30  35  35  GLN GLN B . n 
B 1 31  GLY 31  36  36  GLY GLY B . n 
B 1 32  GLN 32  37  37  GLN GLN B . n 
B 1 33  LYS 33  38  38  LYS LYS B . n 
B 1 34  ARG 34  39  39  ARG ARG B . n 
B 1 35  LYS 35  40  40  LYS LYS B . n 
B 1 36  GLY 36  41  41  GLY GLY B . n 
B 1 37  VAL 37  42  42  VAL VAL B . n 
B 1 38  GLU 38  43  43  GLU GLU B . n 
B 1 39  HIS 39  44  44  HIS HIS B . n 
B 1 40  GLY 40  45  45  GLY GLY B . n 
B 1 41  PRO 41  46  46  PRO PRO B . n 
B 1 42  ALA 42  47  47  ALA ALA B . n 
B 1 43  ALA 43  48  48  ALA ALA B . n 
B 1 44  ILE 44  49  49  ILE ILE B . n 
B 1 45  ARG 45  50  50  ARG ARG B . n 
B 1 46  GLU 46  51  51  GLU GLU B . n 
B 1 47  ALA 47  52  52  ALA ALA B . n 
B 1 48  GLY 48  53  53  GLY GLY B . n 
B 1 49  LEU 49  54  54  LEU LEU B . n 
B 1 50  MET 50  55  55  MET MET B . n 
B 1 51  LYS 51  56  56  LYS LYS B . n 
B 1 52  ARG 52  57  57  ARG ARG B . n 
B 1 53  LEU 53  58  58  LEU LEU B . n 
B 1 54  SER 54  59  59  SER SER B . n 
B 1 55  SER 55  60  60  SER SER B . n 
B 1 56  LEU 56  61  61  LEU LEU B . n 
B 1 57  GLY 57  62  62  GLY GLY B . n 
B 1 58  CYS 58  63  63  CYS CYS B . n 
B 1 59  HIS 59  64  64  HIS HIS B . n 
B 1 60  LEU 60  65  65  LEU LEU B . n 
B 1 61  LYS 61  66  66  LYS LYS B . n 
B 1 62  ASP 62  67  67  ASP ASP B . n 
B 1 63  PHE 63  68  68  PHE PHE B . n 
B 1 64  GLY 64  69  69  GLY GLY B . n 
B 1 65  ASP 65  70  70  ASP ASP B . n 
B 1 66  LEU 66  71  71  LEU LEU B . n 
B 1 67  SER 67  72  72  SER SER B . n 
B 1 68  PHE 68  73  73  PHE PHE B . n 
B 1 69  THR 69  74  74  THR THR B . n 
B 1 70  PRO 70  75  75  PRO PRO B . n 
B 1 71  VAL 71  76  76  VAL VAL B . n 
B 1 72  PRO 72  77  ?   ?   ?   B . n 
B 1 73  LYS 73  78  ?   ?   ?   B . n 
B 1 74  ASP 74  79  ?   ?   ?   B . n 
B 1 75  ASP 75  80  80  ASP ASP B . n 
B 1 76  LEU 76  81  81  LEU LEU B . n 
B 1 77  TYR 77  82  82  TYR TYR B . n 
B 1 78  ASN 78  83  83  ASN ASN B . n 
B 1 79  ASN 79  84  84  ASN ASN B . n 
B 1 80  LEU 80  85  85  LEU LEU B . n 
B 1 81  ILE 81  86  86  ILE ILE B . n 
B 1 82  VAL 82  87  87  VAL VAL B . n 
B 1 83  ASN 83  88  88  ASN ASN B . n 
B 1 84  PRO 84  89  89  PRO PRO B . n 
B 1 85  ARG 85  90  90  ARG ARG B . n 
B 1 86  SER 86  91  91  SER SER B . n 
B 1 87  VAL 87  92  92  VAL VAL B . n 
B 1 88  GLY 88  93  93  GLY GLY B . n 
B 1 89  LEU 89  94  94  LEU LEU B . n 
B 1 90  ALA 90  95  95  ALA ALA B . n 
B 1 91  ASN 91  96  96  ASN ASN B . n 
B 1 92  GLN 92  97  97  GLN GLN B . n 
B 1 93  GLU 93  98  98  GLU GLU B . n 
B 1 94  LEU 94  99  99  LEU LEU B . n 
B 1 95  ALA 95  100 100 ALA ALA B . n 
B 1 96  GLU 96  101 101 GLU GLU B . n 
B 1 97  VAL 97  102 102 VAL VAL B . n 
B 1 98  VAL 98  103 103 VAL VAL B . n 
B 1 99  SER 99  104 104 SER SER B . n 
B 1 100 ARG 100 105 105 ARG ARG B . n 
B 1 101 ALA 101 106 106 ALA ALA B . n 
B 1 102 VAL 102 107 107 VAL VAL B . n 
B 1 103 SER 103 108 108 SER SER B . n 
B 1 104 ASP 104 109 109 ASP ASP B . n 
B 1 105 GLY 105 110 110 GLY GLY B . n 
B 1 106 TYR 106 111 111 TYR TYR B . n 
B 1 107 SER 107 112 112 SER SER B . n 
B 1 108 CYS 108 113 113 CYS CYS B . n 
B 1 109 VAL 109 114 114 VAL VAL B . n 
B 1 110 THR 110 115 115 THR THR B . n 
B 1 111 LEU 111 116 116 LEU LEU B . n 
B 1 112 GLY 112 117 117 GLY GLY B . n 
B 1 113 GLY 113 118 118 GLY GLY B . n 
B 1 114 ASP 114 119 119 ASP ASP B . n 
B 1 115 HIS 115 120 120 HIS HIS B . n 
B 1 116 SER 116 121 121 SER SER B . n 
B 1 117 LEU 117 122 122 LEU LEU B . n 
B 1 118 ALA 118 123 123 ALA ALA B . n 
B 1 119 ILE 119 124 124 ILE ILE B . n 
B 1 120 GLY 120 125 125 GLY GLY B . n 
B 1 121 THR 121 126 126 THR THR B . n 
B 1 122 ILE 122 127 127 ILE ILE B . n 
B 1 123 SER 123 128 128 SER SER B . n 
B 1 124 GLY 124 129 129 GLY GLY B . n 
B 1 125 HIS 125 130 130 HIS HIS B . n 
B 1 126 ALA 126 131 131 ALA ALA B . n 
B 1 127 ARG 127 132 132 ARG ARG B . n 
B 1 128 HIS 128 133 133 HIS HIS B . n 
B 1 129 CYS 129 134 134 CYS CYS B . n 
B 1 130 PRO 130 135 135 PRO PRO B . n 
B 1 131 ASP 131 136 136 ASP ASP B . n 
B 1 132 LEU 132 137 137 LEU LEU B . n 
B 1 133 CYS 133 138 138 CYS CYS B . n 
B 1 134 VAL 134 139 139 VAL VAL B . n 
B 1 135 VAL 135 140 140 VAL VAL B . n 
B 1 136 TRP 136 141 141 TRP TRP B . n 
B 1 137 VAL 137 142 142 VAL VAL B . n 
B 1 138 ASP 138 143 143 ASP ASP B . n 
B 1 139 ALA 139 144 144 ALA ALA B . n 
B 1 140 HIS 140 145 145 HIS HIS B . n 
B 1 141 ALA 141 146 146 ALA ALA B . n 
B 1 142 ASP 142 147 147 ASP ASP B . n 
B 1 143 ILE 143 148 148 ILE ILE B . n 
B 1 144 ASN 144 149 149 ASN ASN B . n 
B 1 145 THR 145 150 150 THR THR B . n 
B 1 146 PRO 146 151 151 PRO PRO B . n 
B 1 147 LEU 147 152 152 LEU LEU B . n 
B 1 148 THR 148 153 153 THR THR B . n 
B 1 149 THR 149 154 154 THR THR B . n 
B 1 150 SER 150 155 155 SER SER B . n 
B 1 151 SER 151 156 156 SER SER B . n 
B 1 152 GLY 152 157 157 GLY GLY B . n 
B 1 153 ASN 153 158 158 ASN ASN B . n 
B 1 154 LEU 154 159 159 LEU LEU B . n 
B 1 155 HIS 155 160 160 HIS HIS B . n 
B 1 156 GLY 156 161 161 GLY GLY B . n 
B 1 157 GLN 157 162 162 GLN GLN B . n 
B 1 158 PRO 158 163 163 PRO PRO B . n 
B 1 159 VAL 159 164 164 VAL VAL B . n 
B 1 160 SER 160 165 165 SER SER B . n 
B 1 161 PHE 161 166 166 PHE PHE B . n 
B 1 162 LEU 162 167 167 LEU LEU B . n 
B 1 163 LEU 163 168 168 LEU LEU B . n 
B 1 164 ARG 164 169 169 ARG ARG B . n 
B 1 165 GLU 165 170 170 GLU GLU B . n 
B 1 166 LEU 166 171 171 LEU LEU B . n 
B 1 167 GLN 167 172 172 GLN GLN B . n 
B 1 168 ASP 168 173 173 ASP ASP B . n 
B 1 169 LYS 169 174 174 LYS LYS B . n 
B 1 170 VAL 170 175 175 VAL VAL B . n 
B 1 171 PRO 171 176 176 PRO PRO B . n 
B 1 172 GLN 172 177 177 GLN GLN B . n 
B 1 173 LEU 173 178 178 LEU LEU B . n 
B 1 174 PRO 174 179 179 PRO PRO B . n 
B 1 175 GLY 175 180 180 GLY GLY B . n 
B 1 176 PHE 176 181 181 PHE PHE B . n 
B 1 177 SER 177 182 182 SER SER B . n 
B 1 178 TRP 178 183 183 TRP TRP B . n 
B 1 179 ILE 179 184 184 ILE ILE B . n 
B 1 180 LYS 180 185 185 LYS LYS B . n 
B 1 181 PRO 181 186 186 PRO PRO B . n 
B 1 182 CYS 182 187 187 CYS CYS B . n 
B 1 183 ILE 183 188 188 ILE ILE B . n 
B 1 184 SER 184 189 189 SER SER B . n 
B 1 185 SER 185 190 190 SER SER B . n 
B 1 186 ALA 186 191 191 ALA ALA B . n 
B 1 187 SER 187 192 192 SER SER B . n 
B 1 188 ILE 188 193 193 ILE ILE B . n 
B 1 189 VAL 189 194 194 VAL VAL B . n 
B 1 190 TYR 190 195 195 TYR TYR B . n 
B 1 191 ILE 191 196 196 ILE ILE B . n 
B 1 192 GLY 192 197 197 GLY GLY B . n 
B 1 193 LEU 193 198 198 LEU LEU B . n 
B 1 194 ARG 194 199 199 ARG ARG B . n 
B 1 195 ASP 195 200 200 ASP ASP B . n 
B 1 196 VAL 196 201 201 VAL VAL B . n 
B 1 197 ASP 197 202 202 ASP ASP B . n 
B 1 198 PRO 198 203 203 PRO PRO B . n 
B 1 199 PRO 199 204 204 PRO PRO B . n 
B 1 200 GLU 200 205 205 GLU GLU B . n 
B 1 201 HIS 201 206 206 HIS HIS B . n 
B 1 202 PHE 202 207 207 PHE PHE B . n 
B 1 203 ILE 203 208 208 ILE ILE B . n 
B 1 204 LEU 204 209 209 LEU LEU B . n 
B 1 205 LYS 205 210 210 LYS LYS B . n 
B 1 206 ASN 206 211 211 ASN ASN B . n 
B 1 207 TYR 207 212 212 TYR TYR B . n 
B 1 208 ASP 208 213 213 ASP ASP B . n 
B 1 209 ILE 209 214 214 ILE ILE B . n 
B 1 210 GLN 210 215 215 GLN GLN B . n 
B 1 211 TYR 211 216 216 TYR TYR B . n 
B 1 212 PHE 212 217 217 PHE PHE B . n 
B 1 213 SER 213 218 218 SER SER B . n 
B 1 214 MET 214 219 219 MET MET B . n 
B 1 215 ARG 215 220 220 ARG ARG B . n 
B 1 216 ASP 216 221 221 ASP ASP B . n 
B 1 217 ILE 217 222 222 ILE ILE B . n 
B 1 218 ASP 218 223 223 ASP ASP B . n 
B 1 219 ARG 219 224 224 ARG ARG B . n 
B 1 220 LEU 220 225 225 LEU LEU B . n 
B 1 221 GLY 221 226 226 GLY GLY B . n 
B 1 222 ILE 222 227 227 ILE ILE B . n 
B 1 223 GLN 223 228 228 GLN GLN B . n 
B 1 224 LYS 224 229 229 LYS LYS B . n 
B 1 225 VAL 225 230 230 VAL VAL B . n 
B 1 226 MET 226 231 231 MET MET B . n 
B 1 227 GLU 227 232 232 GLU GLU B . n 
B 1 228 ARG 228 233 233 ARG ARG B . n 
B 1 229 THR 229 234 234 THR THR B . n 
B 1 230 PHE 230 235 235 PHE PHE B . n 
B 1 231 ASP 231 236 236 ASP ASP B . n 
B 1 232 LEU 232 237 237 LEU LEU B . n 
B 1 233 LEU 233 238 238 LEU LEU B . n 
B 1 234 ILE 234 239 239 ILE ILE B . n 
B 1 235 GLY 235 240 240 GLY GLY B . n 
B 1 236 LYS 236 241 241 LYS LYS B . n 
B 1 237 ARG 237 242 242 ARG ARG B . n 
B 1 238 GLN 238 243 243 GLN GLN B . n 
B 1 239 ARG 239 244 244 ARG ARG B . n 
B 1 240 PRO 240 245 245 PRO PRO B . n 
B 1 241 ILE 241 246 246 ILE ILE B . n 
B 1 242 HIS 242 247 247 HIS HIS B . n 
B 1 243 LEU 243 248 248 LEU LEU B . n 
B 1 244 SER 244 249 249 SER SER B . n 
B 1 245 PHE 245 250 250 PHE PHE B . n 
B 1 246 ASP 246 251 251 ASP ASP B . n 
B 1 247 ILE 247 252 252 ILE ILE B . n 
B 1 248 ASP 248 253 253 ASP ASP B . n 
B 1 249 ALA 249 254 254 ALA ALA B . n 
B 1 250 PHE 250 255 255 PHE PHE B . n 
B 1 251 ASP 251 256 256 ASP ASP B . n 
B 1 252 PRO 252 257 257 PRO PRO B . n 
B 1 253 THR 253 258 258 THR THR B . n 
B 1 254 LEU 254 259 259 LEU LEU B . n 
B 1 255 ALA 255 260 260 ALA ALA B . n 
B 1 256 PRO 256 261 261 PRO PRO B . n 
B 1 257 ALA 257 262 262 ALA ALA B . n 
B 1 258 THR 258 263 263 THR THR B . n 
B 1 259 GLY 259 264 264 GLY GLY B . n 
B 1 260 THR 260 265 265 THR THR B . n 
B 1 261 PRO 261 266 266 PRO PRO B . n 
B 1 262 VAL 262 267 267 VAL VAL B . n 
B 1 263 VAL 263 268 268 VAL VAL B . n 
B 1 264 GLY 264 269 269 GLY GLY B . n 
B 1 265 GLY 265 270 270 GLY GLY B . n 
B 1 266 LEU 266 271 271 LEU LEU B . n 
B 1 267 THR 267 272 272 THR THR B . n 
B 1 268 TYR 268 273 273 TYR TYR B . n 
B 1 269 ARG 269 274 274 ARG ARG B . n 
B 1 270 GLU 270 275 275 GLU GLU B . n 
B 1 271 GLY 271 276 276 GLY GLY B . n 
B 1 272 MET 272 277 277 MET MET B . n 
B 1 273 TYR 273 278 278 TYR TYR B . n 
B 1 274 ILE 274 279 279 ILE ILE B . n 
B 1 275 ALA 275 280 280 ALA ALA B . n 
B 1 276 GLU 276 281 281 GLU GLU B . n 
B 1 277 GLU 277 282 282 GLU GLU B . n 
B 1 278 ILE 278 283 283 ILE ILE B . n 
B 1 279 HIS 279 284 284 HIS HIS B . n 
B 1 280 ASN 280 285 285 ASN ASN B . n 
B 1 281 THR 281 286 286 THR THR B . n 
B 1 282 GLY 282 287 287 GLY GLY B . n 
B 1 283 LEU 283 288 288 LEU LEU B . n 
B 1 284 LEU 284 289 289 LEU LEU B . n 
B 1 285 SER 285 290 290 SER SER B . n 
B 1 286 ALA 286 291 291 ALA ALA B . n 
B 1 287 LEU 287 292 292 LEU LEU B . n 
B 1 288 ASP 288 293 293 ASP ASP B . n 
B 1 289 LEU 289 294 294 LEU LEU B . n 
B 1 290 VAL 290 295 295 VAL VAL B . n 
B 1 291 GLU 291 296 296 GLU GLU B . n 
B 1 292 VAL 292 297 297 VAL VAL B . n 
B 1 293 ASN 293 298 298 ASN ASN B . n 
B 1 294 PRO 294 299 299 PRO PRO B . n 
B 1 295 GLN 295 300 300 GLN GLN B . n 
B 1 296 LEU 296 301 301 LEU LEU B . n 
B 1 297 ALA 297 302 302 ALA ALA B . n 
B 1 298 THR 298 303 303 THR THR B . n 
B 1 299 SER 299 304 304 SER SER B . n 
B 1 300 GLU 300 305 305 GLU GLU B . n 
B 1 301 GLU 301 306 306 GLU GLU B . n 
B 1 302 GLU 302 307 307 GLU GLU B . n 
B 1 303 ALA 303 308 308 ALA ALA B . n 
B 1 304 LYS 304 309 309 LYS LYS B . n 
B 1 305 THR 305 310 310 THR THR B . n 
B 1 306 THR 306 311 311 THR THR B . n 
B 1 307 ALA 307 312 312 ALA ALA B . n 
B 1 308 ASN 308 313 313 ASN ASN B . n 
B 1 309 LEU 309 314 314 LEU LEU B . n 
B 1 310 ALA 310 315 315 ALA ALA B . n 
B 1 311 VAL 311 316 316 VAL VAL B . n 
B 1 312 ASP 312 317 317 ASP ASP B . n 
B 1 313 VAL 313 318 318 VAL VAL B . n 
B 1 314 ILE 314 319 319 ILE ILE B . n 
B 1 315 ALA 315 320 320 ALA ALA B . n 
B 1 316 SER 316 321 321 SER SER B . n 
B 1 317 SER 317 322 322 SER SER B . n 
B 1 318 PHE 318 323 323 PHE PHE B . n 
B 1 319 GLY 319 324 324 GLY GLY B . n 
B 1 320 GLN 320 325 325 GLN GLN B . n 
B 1 321 THR 321 326 326 THR THR B . n 
B 1 322 ARG 322 327 327 ARG ARG B . n 
B 1 323 GLU 323 328 328 GLU GLU B . n 
B 1 324 GLY 324 329 329 GLY GLY B . n 
B 1 325 GLY 325 330 330 GLY GLY B . n 
B 1 326 HIS 326 331 331 HIS HIS B . n 
B 1 327 ILE 327 332 332 ILE ILE B . n 
B 1 328 VAL 328 333 333 VAL VAL B . n 
B 1 329 TYR 329 334 334 TYR TYR B . n 
B 1 330 ASP 330 335 335 ASP ASP B . n 
B 1 331 GLN 331 336 336 GLN GLN B . n 
B 1 332 LEU 332 337 337 LEU LEU B . n 
B 1 333 PRO 333 338 338 PRO PRO B . n 
B 1 334 THR 334 339 339 THR THR B . n 
B 1 335 PRO 335 340 340 PRO PRO B . n 
B 1 336 SER 336 341 341 SER SER B . n 
C 1 1   MET 1   6   ?   ?   ?   C . n 
C 1 2   HIS 2   7   ?   ?   ?   C . n 
C 1 3   HIS 3   8   ?   ?   ?   C . n 
C 1 4   HIS 4   9   ?   ?   ?   C . n 
C 1 5   HIS 5   10  ?   ?   ?   C . n 
C 1 6   HIS 6   11  ?   ?   ?   C . n 
C 1 7   HIS 7   12  ?   ?   ?   C . n 
C 1 8   GLY 8   13  ?   ?   ?   C . n 
C 1 9   GLY 9   14  ?   ?   ?   C . n 
C 1 10  GLY 10  15  ?   ?   ?   C . n 
C 1 11  GLU 11  16  ?   ?   ?   C . n 
C 1 12  ASN 12  17  ?   ?   ?   C . n 
C 1 13  LEU 13  18  ?   ?   ?   C . n 
C 1 14  TYR 14  19  ?   ?   ?   C . n 
C 1 15  PHE 15  20  20  PHE PHE C . n 
C 1 16  GLN 16  21  21  GLN GLN C . n 
C 1 17  SER 17  22  22  SER SER C . n 
C 1 18  VAL 18  23  23  VAL VAL C . n 
C 1 19  HIS 19  24  24  HIS HIS C . n 
C 1 20  SER 20  25  25  SER SER C . n 
C 1 21  VAL 21  26  26  VAL VAL C . n 
C 1 22  ALA 22  27  27  ALA ALA C . n 
C 1 23  VAL 23  28  28  VAL VAL C . n 
C 1 24  ILE 24  29  29  ILE ILE C . n 
C 1 25  GLY 25  30  30  GLY GLY C . n 
C 1 26  ALA 26  31  31  ALA ALA C . n 
C 1 27  PRO 27  32  32  PRO PRO C . n 
C 1 28  PHE 28  33  33  PHE PHE C . n 
C 1 29  SER 29  34  34  SER SER C . n 
C 1 30  GLN 30  35  35  GLN GLN C . n 
C 1 31  GLY 31  36  36  GLY GLY C . n 
C 1 32  GLN 32  37  37  GLN GLN C . n 
C 1 33  LYS 33  38  38  LYS LYS C . n 
C 1 34  ARG 34  39  39  ARG ARG C . n 
C 1 35  LYS 35  40  40  LYS LYS C . n 
C 1 36  GLY 36  41  41  GLY GLY C . n 
C 1 37  VAL 37  42  42  VAL VAL C . n 
C 1 38  GLU 38  43  43  GLU GLU C . n 
C 1 39  HIS 39  44  44  HIS HIS C . n 
C 1 40  GLY 40  45  45  GLY GLY C . n 
C 1 41  PRO 41  46  46  PRO PRO C . n 
C 1 42  ALA 42  47  47  ALA ALA C . n 
C 1 43  ALA 43  48  48  ALA ALA C . n 
C 1 44  ILE 44  49  49  ILE ILE C . n 
C 1 45  ARG 45  50  50  ARG ARG C . n 
C 1 46  GLU 46  51  51  GLU GLU C . n 
C 1 47  ALA 47  52  52  ALA ALA C . n 
C 1 48  GLY 48  53  53  GLY GLY C . n 
C 1 49  LEU 49  54  54  LEU LEU C . n 
C 1 50  MET 50  55  55  MET MET C . n 
C 1 51  LYS 51  56  56  LYS LYS C . n 
C 1 52  ARG 52  57  57  ARG ARG C . n 
C 1 53  LEU 53  58  58  LEU LEU C . n 
C 1 54  SER 54  59  59  SER SER C . n 
C 1 55  SER 55  60  60  SER SER C . n 
C 1 56  LEU 56  61  61  LEU LEU C . n 
C 1 57  GLY 57  62  62  GLY GLY C . n 
C 1 58  CYS 58  63  63  CYS CYS C . n 
C 1 59  HIS 59  64  64  HIS HIS C . n 
C 1 60  LEU 60  65  65  LEU LEU C . n 
C 1 61  LYS 61  66  66  LYS LYS C . n 
C 1 62  ASP 62  67  67  ASP ASP C . n 
C 1 63  PHE 63  68  68  PHE PHE C . n 
C 1 64  GLY 64  69  69  GLY GLY C . n 
C 1 65  ASP 65  70  70  ASP ASP C . n 
C 1 66  LEU 66  71  71  LEU LEU C . n 
C 1 67  SER 67  72  72  SER SER C . n 
C 1 68  PHE 68  73  73  PHE PHE C . n 
C 1 69  THR 69  74  74  THR THR C . n 
C 1 70  PRO 70  75  75  PRO PRO C . n 
C 1 71  VAL 71  76  76  VAL VAL C . n 
C 1 72  PRO 72  77  77  PRO PRO C . n 
C 1 73  LYS 73  78  78  LYS LYS C . n 
C 1 74  ASP 74  79  79  ASP ASP C . n 
C 1 75  ASP 75  80  80  ASP ASP C . n 
C 1 76  LEU 76  81  81  LEU LEU C . n 
C 1 77  TYR 77  82  82  TYR TYR C . n 
C 1 78  ASN 78  83  83  ASN ASN C . n 
C 1 79  ASN 79  84  84  ASN ASN C . n 
C 1 80  LEU 80  85  85  LEU LEU C . n 
C 1 81  ILE 81  86  86  ILE ILE C . n 
C 1 82  VAL 82  87  87  VAL VAL C . n 
C 1 83  ASN 83  88  88  ASN ASN C . n 
C 1 84  PRO 84  89  89  PRO PRO C . n 
C 1 85  ARG 85  90  90  ARG ARG C . n 
C 1 86  SER 86  91  91  SER SER C . n 
C 1 87  VAL 87  92  92  VAL VAL C . n 
C 1 88  GLY 88  93  93  GLY GLY C . n 
C 1 89  LEU 89  94  94  LEU LEU C . n 
C 1 90  ALA 90  95  95  ALA ALA C . n 
C 1 91  ASN 91  96  96  ASN ASN C . n 
C 1 92  GLN 92  97  97  GLN GLN C . n 
C 1 93  GLU 93  98  98  GLU GLU C . n 
C 1 94  LEU 94  99  99  LEU LEU C . n 
C 1 95  ALA 95  100 100 ALA ALA C . n 
C 1 96  GLU 96  101 101 GLU GLU C . n 
C 1 97  VAL 97  102 102 VAL VAL C . n 
C 1 98  VAL 98  103 103 VAL VAL C . n 
C 1 99  SER 99  104 104 SER SER C . n 
C 1 100 ARG 100 105 105 ARG ARG C . n 
C 1 101 ALA 101 106 106 ALA ALA C . n 
C 1 102 VAL 102 107 107 VAL VAL C . n 
C 1 103 SER 103 108 108 SER SER C . n 
C 1 104 ASP 104 109 109 ASP ASP C . n 
C 1 105 GLY 105 110 110 GLY GLY C . n 
C 1 106 TYR 106 111 111 TYR TYR C . n 
C 1 107 SER 107 112 112 SER SER C . n 
C 1 108 CYS 108 113 113 CYS CYS C . n 
C 1 109 VAL 109 114 114 VAL VAL C . n 
C 1 110 THR 110 115 115 THR THR C . n 
C 1 111 LEU 111 116 116 LEU LEU C . n 
C 1 112 GLY 112 117 117 GLY GLY C . n 
C 1 113 GLY 113 118 118 GLY GLY C . n 
C 1 114 ASP 114 119 119 ASP ASP C . n 
C 1 115 HIS 115 120 120 HIS HIS C . n 
C 1 116 SER 116 121 121 SER SER C . n 
C 1 117 LEU 117 122 122 LEU LEU C . n 
C 1 118 ALA 118 123 123 ALA ALA C . n 
C 1 119 ILE 119 124 124 ILE ILE C . n 
C 1 120 GLY 120 125 125 GLY GLY C . n 
C 1 121 THR 121 126 126 THR THR C . n 
C 1 122 ILE 122 127 127 ILE ILE C . n 
C 1 123 SER 123 128 128 SER SER C . n 
C 1 124 GLY 124 129 129 GLY GLY C . n 
C 1 125 HIS 125 130 130 HIS HIS C . n 
C 1 126 ALA 126 131 131 ALA ALA C . n 
C 1 127 ARG 127 132 132 ARG ARG C . n 
C 1 128 HIS 128 133 133 HIS HIS C . n 
C 1 129 CYS 129 134 134 CYS CYS C . n 
C 1 130 PRO 130 135 135 PRO PRO C . n 
C 1 131 ASP 131 136 136 ASP ASP C . n 
C 1 132 LEU 132 137 137 LEU LEU C . n 
C 1 133 CYS 133 138 138 CYS CYS C . n 
C 1 134 VAL 134 139 139 VAL VAL C . n 
C 1 135 VAL 135 140 140 VAL VAL C . n 
C 1 136 TRP 136 141 141 TRP TRP C . n 
C 1 137 VAL 137 142 142 VAL VAL C . n 
C 1 138 ASP 138 143 143 ASP ASP C . n 
C 1 139 ALA 139 144 144 ALA ALA C . n 
C 1 140 HIS 140 145 145 HIS HIS C . n 
C 1 141 ALA 141 146 146 ALA ALA C . n 
C 1 142 ASP 142 147 147 ASP ASP C . n 
C 1 143 ILE 143 148 148 ILE ILE C . n 
C 1 144 ASN 144 149 149 ASN ASN C . n 
C 1 145 THR 145 150 150 THR THR C . n 
C 1 146 PRO 146 151 151 PRO PRO C . n 
C 1 147 LEU 147 152 152 LEU LEU C . n 
C 1 148 THR 148 153 153 THR THR C . n 
C 1 149 THR 149 154 154 THR THR C . n 
C 1 150 SER 150 155 155 SER SER C . n 
C 1 151 SER 151 156 156 SER SER C . n 
C 1 152 GLY 152 157 157 GLY GLY C . n 
C 1 153 ASN 153 158 158 ASN ASN C . n 
C 1 154 LEU 154 159 159 LEU LEU C . n 
C 1 155 HIS 155 160 160 HIS HIS C . n 
C 1 156 GLY 156 161 161 GLY GLY C . n 
C 1 157 GLN 157 162 162 GLN GLN C . n 
C 1 158 PRO 158 163 163 PRO PRO C . n 
C 1 159 VAL 159 164 164 VAL VAL C . n 
C 1 160 SER 160 165 165 SER SER C . n 
C 1 161 PHE 161 166 166 PHE PHE C . n 
C 1 162 LEU 162 167 167 LEU LEU C . n 
C 1 163 LEU 163 168 168 LEU LEU C . n 
C 1 164 ARG 164 169 169 ARG ARG C . n 
C 1 165 GLU 165 170 170 GLU GLU C . n 
C 1 166 LEU 166 171 171 LEU LEU C . n 
C 1 167 GLN 167 172 172 GLN GLN C . n 
C 1 168 ASP 168 173 173 ASP ASP C . n 
C 1 169 LYS 169 174 174 LYS LYS C . n 
C 1 170 VAL 170 175 175 VAL VAL C . n 
C 1 171 PRO 171 176 176 PRO PRO C . n 
C 1 172 GLN 172 177 177 GLN GLN C . n 
C 1 173 LEU 173 178 178 LEU LEU C . n 
C 1 174 PRO 174 179 179 PRO PRO C . n 
C 1 175 GLY 175 180 180 GLY GLY C . n 
C 1 176 PHE 176 181 181 PHE PHE C . n 
C 1 177 SER 177 182 182 SER SER C . n 
C 1 178 TRP 178 183 183 TRP TRP C . n 
C 1 179 ILE 179 184 184 ILE ILE C . n 
C 1 180 LYS 180 185 185 LYS LYS C . n 
C 1 181 PRO 181 186 186 PRO PRO C . n 
C 1 182 CYS 182 187 187 CYS CYS C . n 
C 1 183 ILE 183 188 188 ILE ILE C . n 
C 1 184 SER 184 189 189 SER SER C . n 
C 1 185 SER 185 190 190 SER SER C . n 
C 1 186 ALA 186 191 191 ALA ALA C . n 
C 1 187 SER 187 192 192 SER SER C . n 
C 1 188 ILE 188 193 193 ILE ILE C . n 
C 1 189 VAL 189 194 194 VAL VAL C . n 
C 1 190 TYR 190 195 195 TYR TYR C . n 
C 1 191 ILE 191 196 196 ILE ILE C . n 
C 1 192 GLY 192 197 197 GLY GLY C . n 
C 1 193 LEU 193 198 198 LEU LEU C . n 
C 1 194 ARG 194 199 199 ARG ARG C . n 
C 1 195 ASP 195 200 200 ASP ASP C . n 
C 1 196 VAL 196 201 201 VAL VAL C . n 
C 1 197 ASP 197 202 202 ASP ASP C . n 
C 1 198 PRO 198 203 203 PRO PRO C . n 
C 1 199 PRO 199 204 204 PRO PRO C . n 
C 1 200 GLU 200 205 205 GLU GLU C . n 
C 1 201 HIS 201 206 206 HIS HIS C . n 
C 1 202 PHE 202 207 207 PHE PHE C . n 
C 1 203 ILE 203 208 208 ILE ILE C . n 
C 1 204 LEU 204 209 209 LEU LEU C . n 
C 1 205 LYS 205 210 210 LYS LYS C . n 
C 1 206 ASN 206 211 211 ASN ASN C . n 
C 1 207 TYR 207 212 212 TYR TYR C . n 
C 1 208 ASP 208 213 213 ASP ASP C . n 
C 1 209 ILE 209 214 214 ILE ILE C . n 
C 1 210 GLN 210 215 215 GLN GLN C . n 
C 1 211 TYR 211 216 216 TYR TYR C . n 
C 1 212 PHE 212 217 217 PHE PHE C . n 
C 1 213 SER 213 218 218 SER SER C . n 
C 1 214 MET 214 219 219 MET MET C . n 
C 1 215 ARG 215 220 220 ARG ARG C . n 
C 1 216 ASP 216 221 221 ASP ASP C . n 
C 1 217 ILE 217 222 222 ILE ILE C . n 
C 1 218 ASP 218 223 223 ASP ASP C . n 
C 1 219 ARG 219 224 224 ARG ARG C . n 
C 1 220 LEU 220 225 225 LEU LEU C . n 
C 1 221 GLY 221 226 226 GLY GLY C . n 
C 1 222 ILE 222 227 227 ILE ILE C . n 
C 1 223 GLN 223 228 228 GLN GLN C . n 
C 1 224 LYS 224 229 229 LYS LYS C . n 
C 1 225 VAL 225 230 230 VAL VAL C . n 
C 1 226 MET 226 231 231 MET MET C . n 
C 1 227 GLU 227 232 232 GLU GLU C . n 
C 1 228 ARG 228 233 233 ARG ARG C . n 
C 1 229 THR 229 234 234 THR THR C . n 
C 1 230 PHE 230 235 235 PHE PHE C . n 
C 1 231 ASP 231 236 236 ASP ASP C . n 
C 1 232 LEU 232 237 237 LEU LEU C . n 
C 1 233 LEU 233 238 238 LEU LEU C . n 
C 1 234 ILE 234 239 239 ILE ILE C . n 
C 1 235 GLY 235 240 240 GLY GLY C . n 
C 1 236 LYS 236 241 241 LYS LYS C . n 
C 1 237 ARG 237 242 242 ARG ARG C . n 
C 1 238 GLN 238 243 243 GLN GLN C . n 
C 1 239 ARG 239 244 244 ARG ARG C . n 
C 1 240 PRO 240 245 245 PRO PRO C . n 
C 1 241 ILE 241 246 246 ILE ILE C . n 
C 1 242 HIS 242 247 247 HIS HIS C . n 
C 1 243 LEU 243 248 248 LEU LEU C . n 
C 1 244 SER 244 249 249 SER SER C . n 
C 1 245 PHE 245 250 250 PHE PHE C . n 
C 1 246 ASP 246 251 251 ASP ASP C . n 
C 1 247 ILE 247 252 252 ILE ILE C . n 
C 1 248 ASP 248 253 253 ASP ASP C . n 
C 1 249 ALA 249 254 254 ALA ALA C . n 
C 1 250 PHE 250 255 255 PHE PHE C . n 
C 1 251 ASP 251 256 256 ASP ASP C . n 
C 1 252 PRO 252 257 257 PRO PRO C . n 
C 1 253 THR 253 258 258 THR THR C . n 
C 1 254 LEU 254 259 259 LEU LEU C . n 
C 1 255 ALA 255 260 260 ALA ALA C . n 
C 1 256 PRO 256 261 261 PRO PRO C . n 
C 1 257 ALA 257 262 262 ALA ALA C . n 
C 1 258 THR 258 263 263 THR THR C . n 
C 1 259 GLY 259 264 264 GLY GLY C . n 
C 1 260 THR 260 265 265 THR THR C . n 
C 1 261 PRO 261 266 266 PRO PRO C . n 
C 1 262 VAL 262 267 267 VAL VAL C . n 
C 1 263 VAL 263 268 268 VAL VAL C . n 
C 1 264 GLY 264 269 269 GLY GLY C . n 
C 1 265 GLY 265 270 270 GLY GLY C . n 
C 1 266 LEU 266 271 271 LEU LEU C . n 
C 1 267 THR 267 272 272 THR THR C . n 
C 1 268 TYR 268 273 273 TYR TYR C . n 
C 1 269 ARG 269 274 274 ARG ARG C . n 
C 1 270 GLU 270 275 275 GLU GLU C . n 
C 1 271 GLY 271 276 276 GLY GLY C . n 
C 1 272 MET 272 277 277 MET MET C . n 
C 1 273 TYR 273 278 278 TYR TYR C . n 
C 1 274 ILE 274 279 279 ILE ILE C . n 
C 1 275 ALA 275 280 280 ALA ALA C . n 
C 1 276 GLU 276 281 281 GLU GLU C . n 
C 1 277 GLU 277 282 282 GLU GLU C . n 
C 1 278 ILE 278 283 283 ILE ILE C . n 
C 1 279 HIS 279 284 284 HIS HIS C . n 
C 1 280 ASN 280 285 285 ASN ASN C . n 
C 1 281 THR 281 286 286 THR THR C . n 
C 1 282 GLY 282 287 287 GLY GLY C . n 
C 1 283 LEU 283 288 288 LEU LEU C . n 
C 1 284 LEU 284 289 289 LEU LEU C . n 
C 1 285 SER 285 290 290 SER SER C . n 
C 1 286 ALA 286 291 291 ALA ALA C . n 
C 1 287 LEU 287 292 292 LEU LEU C . n 
C 1 288 ASP 288 293 293 ASP ASP C . n 
C 1 289 LEU 289 294 294 LEU LEU C . n 
C 1 290 VAL 290 295 295 VAL VAL C . n 
C 1 291 GLU 291 296 296 GLU GLU C . n 
C 1 292 VAL 292 297 297 VAL VAL C . n 
C 1 293 ASN 293 298 298 ASN ASN C . n 
C 1 294 PRO 294 299 299 PRO PRO C . n 
C 1 295 GLN 295 300 300 GLN GLN C . n 
C 1 296 LEU 296 301 301 LEU LEU C . n 
C 1 297 ALA 297 302 302 ALA ALA C . n 
C 1 298 THR 298 303 303 THR THR C . n 
C 1 299 SER 299 304 304 SER SER C . n 
C 1 300 GLU 300 305 305 GLU GLU C . n 
C 1 301 GLU 301 306 306 GLU GLU C . n 
C 1 302 GLU 302 307 307 GLU GLU C . n 
C 1 303 ALA 303 308 308 ALA ALA C . n 
C 1 304 LYS 304 309 309 LYS LYS C . n 
C 1 305 THR 305 310 310 THR THR C . n 
C 1 306 THR 306 311 311 THR THR C . n 
C 1 307 ALA 307 312 312 ALA ALA C . n 
C 1 308 ASN 308 313 313 ASN ASN C . n 
C 1 309 LEU 309 314 314 LEU LEU C . n 
C 1 310 ALA 310 315 315 ALA ALA C . n 
C 1 311 VAL 311 316 316 VAL VAL C . n 
C 1 312 ASP 312 317 317 ASP ASP C . n 
C 1 313 VAL 313 318 318 VAL VAL C . n 
C 1 314 ILE 314 319 319 ILE ILE C . n 
C 1 315 ALA 315 320 320 ALA ALA C . n 
C 1 316 SER 316 321 321 SER SER C . n 
C 1 317 SER 317 322 322 SER SER C . n 
C 1 318 PHE 318 323 323 PHE PHE C . n 
C 1 319 GLY 319 324 324 GLY GLY C . n 
C 1 320 GLN 320 325 325 GLN GLN C . n 
C 1 321 THR 321 326 326 THR THR C . n 
C 1 322 ARG 322 327 327 ARG ARG C . n 
C 1 323 GLU 323 328 328 GLU GLU C . n 
C 1 324 GLY 324 329 329 GLY GLY C . n 
C 1 325 GLY 325 330 330 GLY GLY C . n 
C 1 326 HIS 326 331 331 HIS HIS C . n 
C 1 327 ILE 327 332 ?   ?   ?   C . n 
C 1 328 VAL 328 333 ?   ?   ?   C . n 
C 1 329 TYR 329 334 ?   ?   ?   C . n 
C 1 330 ASP 330 335 ?   ?   ?   C . n 
C 1 331 GLN 331 336 ?   ?   ?   C . n 
C 1 332 LEU 332 337 ?   ?   ?   C . n 
C 1 333 PRO 333 338 ?   ?   ?   C . n 
C 1 334 THR 334 339 ?   ?   ?   C . n 
C 1 335 PRO 335 340 ?   ?   ?   C . n 
C 1 336 SER 336 341 ?   ?   ?   C . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        PRO 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   PRO 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
D 2 MN  1   401 500 MN  MN  A . 
E 2 MN  1   402 501 MN  MN  A . 
F 3 DMS 1   403 2   DMS DMS A . 
G 3 DMS 1   404 5   DMS DMS A . 
H 4 PRO 1   405 1   PRO INH A . 
I 2 MN  1   401 500 MN  MN  B . 
J 2 MN  1   402 501 MN  MN  B . 
K 3 DMS 1   403 1   DMS DMS B . 
L 3 DMS 1   404 6   DMS DMS B . 
M 4 PRO 1   405 1   PRO INH B . 
N 2 MN  1   401 500 MN  MN  C . 
O 2 MN  1   402 501 MN  MN  C . 
P 3 DMS 1   403 3   DMS DMS C . 
Q 3 DMS 1   404 4   DMS DMS C . 
R 4 PRO 1   405 1   PRO INH C . 
S 5 HOH 1   501 316 HOH HOH A . 
S 5 HOH 2   502 126 HOH HOH A . 
S 5 HOH 3   503 212 HOH HOH A . 
S 5 HOH 4   504 376 HOH HOH A . 
S 5 HOH 5   505 274 HOH HOH A . 
S 5 HOH 6   506 277 HOH HOH A . 
S 5 HOH 7   507 415 HOH HOH A . 
S 5 HOH 8   508 134 HOH HOH A . 
S 5 HOH 9   509 299 HOH HOH A . 
S 5 HOH 10  510 276 HOH HOH A . 
S 5 HOH 11  511 124 HOH HOH A . 
S 5 HOH 12  512 112 HOH HOH A . 
S 5 HOH 13  513 70  HOH HOH A . 
S 5 HOH 14  514 369 HOH HOH A . 
S 5 HOH 15  515 60  HOH HOH A . 
S 5 HOH 16  516 398 HOH HOH A . 
S 5 HOH 17  517 47  HOH HOH A . 
S 5 HOH 18  518 380 HOH HOH A . 
S 5 HOH 19  519 416 HOH HOH A . 
S 5 HOH 20  520 385 HOH HOH A . 
S 5 HOH 21  521 410 HOH HOH A . 
S 5 HOH 22  522 50  HOH HOH A . 
S 5 HOH 23  523 121 HOH HOH A . 
S 5 HOH 24  524 266 HOH HOH A . 
S 5 HOH 25  525 303 HOH HOH A . 
S 5 HOH 26  526 186 HOH HOH A . 
S 5 HOH 27  527 136 HOH HOH A . 
S 5 HOH 28  528 46  HOH HOH A . 
S 5 HOH 29  529 196 HOH HOH A . 
S 5 HOH 30  530 224 HOH HOH A . 
S 5 HOH 31  531 19  HOH HOH A . 
S 5 HOH 32  532 356 HOH HOH A . 
S 5 HOH 33  533 331 HOH HOH A . 
S 5 HOH 34  534 16  HOH HOH A . 
S 5 HOH 35  535 98  HOH HOH A . 
S 5 HOH 36  536 237 HOH HOH A . 
S 5 HOH 37  537 125 HOH HOH A . 
S 5 HOH 38  538 142 HOH HOH A . 
S 5 HOH 39  539 104 HOH HOH A . 
S 5 HOH 40  540 379 HOH HOH A . 
S 5 HOH 41  541 89  HOH HOH A . 
S 5 HOH 42  542 100 HOH HOH A . 
S 5 HOH 43  543 258 HOH HOH A . 
S 5 HOH 44  544 317 HOH HOH A . 
S 5 HOH 45  545 225 HOH HOH A . 
S 5 HOH 46  546 66  HOH HOH A . 
S 5 HOH 47  547 26  HOH HOH A . 
S 5 HOH 48  548 27  HOH HOH A . 
S 5 HOH 49  549 412 HOH HOH A . 
S 5 HOH 50  550 227 HOH HOH A . 
S 5 HOH 51  551 405 HOH HOH A . 
S 5 HOH 52  552 11  HOH HOH A . 
S 5 HOH 53  553 68  HOH HOH A . 
S 5 HOH 54  554 114 HOH HOH A . 
S 5 HOH 55  555 315 HOH HOH A . 
S 5 HOH 56  556 260 HOH HOH A . 
S 5 HOH 57  557 119 HOH HOH A . 
S 5 HOH 58  558 25  HOH HOH A . 
S 5 HOH 59  559 273 HOH HOH A . 
S 5 HOH 60  560 219 HOH HOH A . 
S 5 HOH 61  561 179 HOH HOH A . 
S 5 HOH 62  562 32  HOH HOH A . 
S 5 HOH 63  563 263 HOH HOH A . 
S 5 HOH 64  564 22  HOH HOH A . 
S 5 HOH 65  565 311 HOH HOH A . 
S 5 HOH 66  566 161 HOH HOH A . 
S 5 HOH 67  567 358 HOH HOH A . 
S 5 HOH 68  568 221 HOH HOH A . 
S 5 HOH 69  569 18  HOH HOH A . 
S 5 HOH 70  570 94  HOH HOH A . 
S 5 HOH 71  571 135 HOH HOH A . 
S 5 HOH 72  572 217 HOH HOH A . 
S 5 HOH 73  573 231 HOH HOH A . 
S 5 HOH 74  574 293 HOH HOH A . 
S 5 HOH 75  575 270 HOH HOH A . 
S 5 HOH 76  576 166 HOH HOH A . 
S 5 HOH 77  577 71  HOH HOH A . 
S 5 HOH 78  578 279 HOH HOH A . 
S 5 HOH 79  579 192 HOH HOH A . 
S 5 HOH 80  580 319 HOH HOH A . 
S 5 HOH 81  581 241 HOH HOH A . 
S 5 HOH 82  582 146 HOH HOH A . 
S 5 HOH 83  583 73  HOH HOH A . 
S 5 HOH 84  584 218 HOH HOH A . 
S 5 HOH 85  585 145 HOH HOH A . 
S 5 HOH 86  586 38  HOH HOH A . 
S 5 HOH 87  587 335 HOH HOH A . 
S 5 HOH 88  588 157 HOH HOH A . 
S 5 HOH 89  589 118 HOH HOH A . 
S 5 HOH 90  590 103 HOH HOH A . 
S 5 HOH 91  591 361 HOH HOH A . 
S 5 HOH 92  592 80  HOH HOH A . 
S 5 HOH 93  593 177 HOH HOH A . 
S 5 HOH 94  594 49  HOH HOH A . 
S 5 HOH 95  595 269 HOH HOH A . 
S 5 HOH 96  596 37  HOH HOH A . 
S 5 HOH 97  597 116 HOH HOH A . 
S 5 HOH 98  598 139 HOH HOH A . 
S 5 HOH 99  599 262 HOH HOH A . 
S 5 HOH 100 600 131 HOH HOH A . 
S 5 HOH 101 601 110 HOH HOH A . 
S 5 HOH 102 602 232 HOH HOH A . 
S 5 HOH 103 603 117 HOH HOH A . 
S 5 HOH 104 604 300 HOH HOH A . 
S 5 HOH 105 605 383 HOH HOH A . 
S 5 HOH 106 606 54  HOH HOH A . 
S 5 HOH 107 607 301 HOH HOH A . 
S 5 HOH 108 608 182 HOH HOH A . 
S 5 HOH 109 609 247 HOH HOH A . 
S 5 HOH 110 610 158 HOH HOH A . 
S 5 HOH 111 611 172 HOH HOH A . 
S 5 HOH 112 612 81  HOH HOH A . 
S 5 HOH 113 613 354 HOH HOH A . 
S 5 HOH 114 614 153 HOH HOH A . 
S 5 HOH 115 615 342 HOH HOH A . 
S 5 HOH 116 616 349 HOH HOH A . 
S 5 HOH 117 617 418 HOH HOH A . 
S 5 HOH 118 618 96  HOH HOH A . 
S 5 HOH 119 619 324 HOH HOH A . 
S 5 HOH 120 620 341 HOH HOH A . 
S 5 HOH 121 621 348 HOH HOH A . 
S 5 HOH 122 622 353 HOH HOH A . 
S 5 HOH 123 623 78  HOH HOH A . 
S 5 HOH 124 624 222 HOH HOH A . 
S 5 HOH 125 625 351 HOH HOH A . 
S 5 HOH 126 626 246 HOH HOH A . 
S 5 HOH 127 627 236 HOH HOH A . 
S 5 HOH 128 628 123 HOH HOH A . 
S 5 HOH 129 629 169 HOH HOH A . 
S 5 HOH 130 630 79  HOH HOH A . 
T 5 HOH 1   501 323 HOH HOH B . 
T 5 HOH 2   502 381 HOH HOH B . 
T 5 HOH 3   503 108 HOH HOH B . 
T 5 HOH 4   504 366 HOH HOH B . 
T 5 HOH 5   505 389 HOH HOH B . 
T 5 HOH 6   506 240 HOH HOH B . 
T 5 HOH 7   507 176 HOH HOH B . 
T 5 HOH 8   508 257 HOH HOH B . 
T 5 HOH 9   509 178 HOH HOH B . 
T 5 HOH 10  510 238 HOH HOH B . 
T 5 HOH 11  511 154 HOH HOH B . 
T 5 HOH 12  512 365 HOH HOH B . 
T 5 HOH 13  513 306 HOH HOH B . 
T 5 HOH 14  514 203 HOH HOH B . 
T 5 HOH 15  515 95  HOH HOH B . 
T 5 HOH 16  516 127 HOH HOH B . 
T 5 HOH 17  517 4   HOH HOH B . 
T 5 HOH 18  518 93  HOH HOH B . 
T 5 HOH 19  519 140 HOH HOH B . 
T 5 HOH 20  520 83  HOH HOH B . 
T 5 HOH 21  521 41  HOH HOH B . 
T 5 HOH 22  522 180 HOH HOH B . 
T 5 HOH 23  523 245 HOH HOH B . 
T 5 HOH 24  524 132 HOH HOH B . 
T 5 HOH 25  525 57  HOH HOH B . 
T 5 HOH 26  526 51  HOH HOH B . 
T 5 HOH 27  527 191 HOH HOH B . 
T 5 HOH 28  528 411 HOH HOH B . 
T 5 HOH 29  529 407 HOH HOH B . 
T 5 HOH 30  530 181 HOH HOH B . 
T 5 HOH 31  531 397 HOH HOH B . 
T 5 HOH 32  532 206 HOH HOH B . 
T 5 HOH 33  533 193 HOH HOH B . 
T 5 HOH 34  534 129 HOH HOH B . 
T 5 HOH 35  535 368 HOH HOH B . 
T 5 HOH 36  536 413 HOH HOH B . 
T 5 HOH 37  537 76  HOH HOH B . 
T 5 HOH 38  538 400 HOH HOH B . 
T 5 HOH 39  539 202 HOH HOH B . 
T 5 HOH 40  540 271 HOH HOH B . 
T 5 HOH 41  541 147 HOH HOH B . 
T 5 HOH 42  542 370 HOH HOH B . 
T 5 HOH 43  543 259 HOH HOH B . 
T 5 HOH 44  544 233 HOH HOH B . 
T 5 HOH 45  545 17  HOH HOH B . 
T 5 HOH 46  546 359 HOH HOH B . 
T 5 HOH 47  547 14  HOH HOH B . 
T 5 HOH 48  548 165 HOH HOH B . 
T 5 HOH 49  549 86  HOH HOH B . 
T 5 HOH 50  550 2   HOH HOH B . 
T 5 HOH 51  551 7   HOH HOH B . 
T 5 HOH 52  552 214 HOH HOH B . 
T 5 HOH 53  553 321 HOH HOH B . 
T 5 HOH 54  554 382 HOH HOH B . 
T 5 HOH 55  555 163 HOH HOH B . 
T 5 HOH 56  556 310 HOH HOH B . 
T 5 HOH 57  557 228 HOH HOH B . 
T 5 HOH 58  558 357 HOH HOH B . 
T 5 HOH 59  559 390 HOH HOH B . 
T 5 HOH 60  560 175 HOH HOH B . 
T 5 HOH 61  561 183 HOH HOH B . 
T 5 HOH 62  562 205 HOH HOH B . 
T 5 HOH 63  563 248 HOH HOH B . 
T 5 HOH 64  564 184 HOH HOH B . 
T 5 HOH 65  565 187 HOH HOH B . 
T 5 HOH 66  566 402 HOH HOH B . 
T 5 HOH 67  567 82  HOH HOH B . 
T 5 HOH 68  568 40  HOH HOH B . 
T 5 HOH 69  569 6   HOH HOH B . 
T 5 HOH 70  570 264 HOH HOH B . 
T 5 HOH 71  571 255 HOH HOH B . 
T 5 HOH 72  572 87  HOH HOH B . 
T 5 HOH 73  573 29  HOH HOH B . 
T 5 HOH 74  574 195 HOH HOH B . 
T 5 HOH 75  575 197 HOH HOH B . 
T 5 HOH 76  576 34  HOH HOH B . 
T 5 HOH 77  577 239 HOH HOH B . 
T 5 HOH 78  578 77  HOH HOH B . 
T 5 HOH 79  579 235 HOH HOH B . 
T 5 HOH 80  580 215 HOH HOH B . 
T 5 HOH 81  581 363 HOH HOH B . 
T 5 HOH 82  582 36  HOH HOH B . 
T 5 HOH 83  583 419 HOH HOH B . 
T 5 HOH 84  584 194 HOH HOH B . 
T 5 HOH 85  585 244 HOH HOH B . 
T 5 HOH 86  586 256 HOH HOH B . 
T 5 HOH 87  587 64  HOH HOH B . 
T 5 HOH 88  588 401 HOH HOH B . 
T 5 HOH 89  589 152 HOH HOH B . 
T 5 HOH 90  590 21  HOH HOH B . 
T 5 HOH 91  591 399 HOH HOH B . 
T 5 HOH 92  592 249 HOH HOH B . 
T 5 HOH 93  593 207 HOH HOH B . 
T 5 HOH 94  594 261 HOH HOH B . 
T 5 HOH 95  595 63  HOH HOH B . 
T 5 HOH 96  596 378 HOH HOH B . 
T 5 HOH 97  597 296 HOH HOH B . 
T 5 HOH 98  598 107 HOH HOH B . 
T 5 HOH 99  599 384 HOH HOH B . 
T 5 HOH 100 600 327 HOH HOH B . 
T 5 HOH 101 601 67  HOH HOH B . 
T 5 HOH 102 602 346 HOH HOH B . 
T 5 HOH 103 603 272 HOH HOH B . 
T 5 HOH 104 604 304 HOH HOH B . 
T 5 HOH 105 605 42  HOH HOH B . 
T 5 HOH 106 606 337 HOH HOH B . 
T 5 HOH 107 607 201 HOH HOH B . 
T 5 HOH 108 608 414 HOH HOH B . 
T 5 HOH 109 609 334 HOH HOH B . 
T 5 HOH 110 610 290 HOH HOH B . 
T 5 HOH 111 611 347 HOH HOH B . 
T 5 HOH 112 612 350 HOH HOH B . 
U 5 HOH 1   501 329 HOH HOH C . 
U 5 HOH 2   502 223 HOH HOH C . 
U 5 HOH 3   503 109 HOH HOH C . 
U 5 HOH 4   504 115 HOH HOH C . 
U 5 HOH 5   505 90  HOH HOH C . 
U 5 HOH 6   506 386 HOH HOH C . 
U 5 HOH 7   507 230 HOH HOH C . 
U 5 HOH 8   508 209 HOH HOH C . 
U 5 HOH 9   509 65  HOH HOH C . 
U 5 HOH 10  510 242 HOH HOH C . 
U 5 HOH 11  511 210 HOH HOH C . 
U 5 HOH 12  512 62  HOH HOH C . 
U 5 HOH 13  513 171 HOH HOH C . 
U 5 HOH 14  514 278 HOH HOH C . 
U 5 HOH 15  515 395 HOH HOH C . 
U 5 HOH 16  516 56  HOH HOH C . 
U 5 HOH 17  517 295 HOH HOH C . 
U 5 HOH 18  518 133 HOH HOH C . 
U 5 HOH 19  519 265 HOH HOH C . 
U 5 HOH 20  520 31  HOH HOH C . 
U 5 HOH 21  521 55  HOH HOH C . 
U 5 HOH 22  522 53  HOH HOH C . 
U 5 HOH 23  523 30  HOH HOH C . 
U 5 HOH 24  524 99  HOH HOH C . 
U 5 HOH 25  525 204 HOH HOH C . 
U 5 HOH 26  526 367 HOH HOH C . 
U 5 HOH 27  527 74  HOH HOH C . 
U 5 HOH 28  528 387 HOH HOH C . 
U 5 HOH 29  529 52  HOH HOH C . 
U 5 HOH 30  530 39  HOH HOH C . 
U 5 HOH 31  531 105 HOH HOH C . 
U 5 HOH 32  532 189 HOH HOH C . 
U 5 HOH 33  533 143 HOH HOH C . 
U 5 HOH 34  534 200 HOH HOH C . 
U 5 HOH 35  535 185 HOH HOH C . 
U 5 HOH 36  536 392 HOH HOH C . 
U 5 HOH 37  537 128 HOH HOH C . 
U 5 HOH 38  538 148 HOH HOH C . 
U 5 HOH 39  539 253 HOH HOH C . 
U 5 HOH 40  540 97  HOH HOH C . 
U 5 HOH 41  541 149 HOH HOH C . 
U 5 HOH 42  542 404 HOH HOH C . 
U 5 HOH 43  543 330 HOH HOH C . 
U 5 HOH 44  544 61  HOH HOH C . 
U 5 HOH 45  545 28  HOH HOH C . 
U 5 HOH 46  546 45  HOH HOH C . 
U 5 HOH 47  547 302 HOH HOH C . 
U 5 HOH 48  548 174 HOH HOH C . 
U 5 HOH 49  549 208 HOH HOH C . 
U 5 HOH 50  550 408 HOH HOH C . 
U 5 HOH 51  551 92  HOH HOH C . 
U 5 HOH 52  552 88  HOH HOH C . 
U 5 HOH 53  553 229 HOH HOH C . 
U 5 HOH 54  554 48  HOH HOH C . 
U 5 HOH 55  555 75  HOH HOH C . 
U 5 HOH 56  556 8   HOH HOH C . 
U 5 HOH 57  557 168 HOH HOH C . 
U 5 HOH 58  558 24  HOH HOH C . 
U 5 HOH 59  559 308 HOH HOH C . 
U 5 HOH 60  560 322 HOH HOH C . 
U 5 HOH 61  561 406 HOH HOH C . 
U 5 HOH 62  562 160 HOH HOH C . 
U 5 HOH 63  563 69  HOH HOH C . 
U 5 HOH 64  564 198 HOH HOH C . 
U 5 HOH 65  565 91  HOH HOH C . 
U 5 HOH 66  566 199 HOH HOH C . 
U 5 HOH 67  567 106 HOH HOH C . 
U 5 HOH 68  568 43  HOH HOH C . 
U 5 HOH 69  569 252 HOH HOH C . 
U 5 HOH 70  570 313 HOH HOH C . 
U 5 HOH 71  571 167 HOH HOH C . 
U 5 HOH 72  572 155 HOH HOH C . 
U 5 HOH 73  573 281 HOH HOH C . 
U 5 HOH 74  574 102 HOH HOH C . 
U 5 HOH 75  575 396 HOH HOH C . 
U 5 HOH 76  576 159 HOH HOH C . 
U 5 HOH 77  577 15  HOH HOH C . 
U 5 HOH 78  578 164 HOH HOH C . 
U 5 HOH 79  579 130 HOH HOH C . 
U 5 HOH 80  580 120 HOH HOH C . 
U 5 HOH 81  581 420 HOH HOH C . 
U 5 HOH 82  582 297 HOH HOH C . 
U 5 HOH 83  583 84  HOH HOH C . 
U 5 HOH 84  584 162 HOH HOH C . 
U 5 HOH 85  585 35  HOH HOH C . 
U 5 HOH 86  586 318 HOH HOH C . 
U 5 HOH 87  587 59  HOH HOH C . 
U 5 HOH 88  588 268 HOH HOH C . 
U 5 HOH 89  589 320 HOH HOH C . 
U 5 HOH 90  590 282 HOH HOH C . 
U 5 HOH 91  591 190 HOH HOH C . 
U 5 HOH 92  592 144 HOH HOH C . 
U 5 HOH 93  593 213 HOH HOH C . 
U 5 HOH 94  594 326 HOH HOH C . 
U 5 HOH 95  595 234 HOH HOH C . 
U 5 HOH 96  596 58  HOH HOH C . 
U 5 HOH 97  597 23  HOH HOH C . 
U 5 HOH 98  598 333 HOH HOH C . 
U 5 HOH 99  599 5   HOH HOH C . 
U 5 HOH 100 600 226 HOH HOH C . 
U 5 HOH 101 601 309 HOH HOH C . 
U 5 HOH 102 602 72  HOH HOH C . 
U 5 HOH 103 603 101 HOH HOH C . 
U 5 HOH 104 604 211 HOH HOH C . 
U 5 HOH 105 605 362 HOH HOH C . 
U 5 HOH 106 606 33  HOH HOH C . 
U 5 HOH 107 607 312 HOH HOH C . 
U 5 HOH 108 608 150 HOH HOH C . 
U 5 HOH 109 609 288 HOH HOH C . 
U 5 HOH 110 610 13  HOH HOH C . 
U 5 HOH 111 611 409 HOH HOH C . 
U 5 HOH 112 612 113 HOH HOH C . 
U 5 HOH 113 613 280 HOH HOH C . 
U 5 HOH 114 614 250 HOH HOH C . 
U 5 HOH 115 615 285 HOH HOH C . 
U 5 HOH 116 616 137 HOH HOH C . 
U 5 HOH 117 617 216 HOH HOH C . 
U 5 HOH 118 618 345 HOH HOH C . 
U 5 HOH 119 619 275 HOH HOH C . 
U 5 HOH 120 620 355 HOH HOH C . 
U 5 HOH 121 621 417 HOH HOH C . 
U 5 HOH 122 622 338 HOH HOH C . 
U 5 HOH 123 623 286 HOH HOH C . 
U 5 HOH 124 624 220 HOH HOH C . 
U 5 HOH 125 625 251 HOH HOH C . 
U 5 HOH 126 626 352 HOH HOH C . 
U 5 HOH 127 627 394 HOH HOH C . 
U 5 HOH 128 628 344 HOH HOH C . 
U 5 HOH 129 629 173 HOH HOH C . 
U 5 HOH 130 630 138 HOH HOH C . 
U 5 HOH 131 631 283 HOH HOH C . 
U 5 HOH 132 632 289 HOH HOH C . 
U 5 HOH 133 633 325 HOH HOH C . 
U 5 HOH 134 634 151 HOH HOH C . 
U 5 HOH 135 635 243 HOH HOH C . 
U 5 HOH 136 636 305 HOH HOH C . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? MOSFLM ? ? ? . 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? SCALA  ? ? ? . 2 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8RGU 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     48.281 
_cell.length_a_esd                 ? 
_cell.length_b                     134.119 
_cell.length_b_esd                 ? 
_cell.length_c                     144.125 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        12 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8RGU 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8RGU 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.18 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          43.49 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
;13-18% PEG3350, 
0.2-0.35M Am.Cit. pH7.0
;
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     CCD 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'RIGAKU SATURN A200' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2011-04-15 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.541 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      'ROTATING ANODE' 
_diffrn_source.target                      ? 
_diffrn_source.type                        'RIGAKU RU300' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.541 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ? 
_diffrn_source.pdbx_synchrotron_site       ? 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8RGU 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.9 
_reflns.d_resolution_low                               144.13 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     74744 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                5.8 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          16.3 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   ? 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.073 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.9 
_reflns_shell.d_res_low                                     2.0 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             6000 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  ? 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.52 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8RGU 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.9 
_refine.ls_d_res_low                             98.18 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     70824 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.91 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       0.24630 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.20541 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.9 
_refine_hist.d_res_low                        98.18 
_refine_hist.number_atoms_solvent             378 
_refine_hist.number_atoms_total               7663 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        7231 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         54 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
_struct.entry_id                     8RGU 
_struct.title                        'Arginase 2 in complex with inhibitor' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8RGU 
_struct_keywords.text            'arginase, inhibitor, complex, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 1 ? 
D N N 2 ? 
E N N 2 ? 
F N N 3 ? 
G N N 3 ? 
H N N 4 ? 
I N N 2 ? 
J N N 2 ? 
K N N 3 ? 
L N N 3 ? 
M N N 4 ? 
N N N 2 ? 
O N N 2 ? 
P N N 3 ? 
Q N N 3 ? 
R N N 4 ? 
S N N 5 ? 
T N N 5 ? 
U N N 5 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    ARGI2_HUMAN 
_struct_ref.pdbx_db_accession          P78540 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAE
VVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGF
SWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAP
ATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPS

;
_struct_ref.pdbx_align_begin           22 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8RGU A 17 ? 336 ? P78540 22 ? 341 ? 22 341 
2 1 8RGU B 17 ? 336 ? P78540 22 ? 341 ? 22 341 
3 1 8RGU C 17 ? 336 ? P78540 22 ? 341 ? 22 341 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8RGU MET A 1  ? UNP P78540 ? ? 'initiating methionine' 6  1  
1 8RGU HIS A 2  ? UNP P78540 ? ? 'expression tag'        7  2  
1 8RGU HIS A 3  ? UNP P78540 ? ? 'expression tag'        8  3  
1 8RGU HIS A 4  ? UNP P78540 ? ? 'expression tag'        9  4  
1 8RGU HIS A 5  ? UNP P78540 ? ? 'expression tag'        10 5  
1 8RGU HIS A 6  ? UNP P78540 ? ? 'expression tag'        11 6  
1 8RGU HIS A 7  ? UNP P78540 ? ? 'expression tag'        12 7  
1 8RGU GLY A 8  ? UNP P78540 ? ? 'expression tag'        13 8  
1 8RGU GLY A 9  ? UNP P78540 ? ? 'expression tag'        14 9  
1 8RGU GLY A 10 ? UNP P78540 ? ? 'expression tag'        15 10 
1 8RGU GLU A 11 ? UNP P78540 ? ? 'expression tag'        16 11 
1 8RGU ASN A 12 ? UNP P78540 ? ? 'expression tag'        17 12 
1 8RGU LEU A 13 ? UNP P78540 ? ? 'expression tag'        18 13 
1 8RGU TYR A 14 ? UNP P78540 ? ? 'expression tag'        19 14 
1 8RGU PHE A 15 ? UNP P78540 ? ? 'expression tag'        20 15 
1 8RGU GLN A 16 ? UNP P78540 ? ? 'expression tag'        21 16 
2 8RGU MET B 1  ? UNP P78540 ? ? 'initiating methionine' 6  17 
2 8RGU HIS B 2  ? UNP P78540 ? ? 'expression tag'        7  18 
2 8RGU HIS B 3  ? UNP P78540 ? ? 'expression tag'        8  19 
2 8RGU HIS B 4  ? UNP P78540 ? ? 'expression tag'        9  20 
2 8RGU HIS B 5  ? UNP P78540 ? ? 'expression tag'        10 21 
2 8RGU HIS B 6  ? UNP P78540 ? ? 'expression tag'        11 22 
2 8RGU HIS B 7  ? UNP P78540 ? ? 'expression tag'        12 23 
2 8RGU GLY B 8  ? UNP P78540 ? ? 'expression tag'        13 24 
2 8RGU GLY B 9  ? UNP P78540 ? ? 'expression tag'        14 25 
2 8RGU GLY B 10 ? UNP P78540 ? ? 'expression tag'        15 26 
2 8RGU GLU B 11 ? UNP P78540 ? ? 'expression tag'        16 27 
2 8RGU ASN B 12 ? UNP P78540 ? ? 'expression tag'        17 28 
2 8RGU LEU B 13 ? UNP P78540 ? ? 'expression tag'        18 29 
2 8RGU TYR B 14 ? UNP P78540 ? ? 'expression tag'        19 30 
2 8RGU PHE B 15 ? UNP P78540 ? ? 'expression tag'        20 31 
2 8RGU GLN B 16 ? UNP P78540 ? ? 'expression tag'        21 32 
3 8RGU MET C 1  ? UNP P78540 ? ? 'initiating methionine' 6  33 
3 8RGU HIS C 2  ? UNP P78540 ? ? 'expression tag'        7  34 
3 8RGU HIS C 3  ? UNP P78540 ? ? 'expression tag'        8  35 
3 8RGU HIS C 4  ? UNP P78540 ? ? 'expression tag'        9  36 
3 8RGU HIS C 5  ? UNP P78540 ? ? 'expression tag'        10 37 
3 8RGU HIS C 6  ? UNP P78540 ? ? 'expression tag'        11 38 
3 8RGU HIS C 7  ? UNP P78540 ? ? 'expression tag'        12 39 
3 8RGU GLY C 8  ? UNP P78540 ? ? 'expression tag'        13 40 
3 8RGU GLY C 9  ? UNP P78540 ? ? 'expression tag'        14 41 
3 8RGU GLY C 10 ? UNP P78540 ? ? 'expression tag'        15 42 
3 8RGU GLU C 11 ? UNP P78540 ? ? 'expression tag'        16 43 
3 8RGU ASN C 12 ? UNP P78540 ? ? 'expression tag'        17 44 
3 8RGU LEU C 13 ? UNP P78540 ? ? 'expression tag'        18 45 
3 8RGU TYR C 14 ? UNP P78540 ? ? 'expression tag'        19 46 
3 8RGU PHE C 15 ? UNP P78540 ? ? 'expression tag'        20 47 
3 8RGU GLN C 16 ? UNP P78540 ? ? 'expression tag'        21 48 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   trimeric 
_pdbx_struct_assembly.oligomeric_count     3 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 7930  ? 
1 MORE         -38   ? 
1 'SSA (A^2)'  34020 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T,U 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLY A 36  ? GLU A 38  ? GLY A 41  GLU A 43  5 ? 3  
HELX_P HELX_P2  AA2 HIS A 39  ? ALA A 47  ? HIS A 44  ALA A 52  1 ? 9  
HELX_P HELX_P3  AA3 GLY A 48  ? LEU A 56  ? GLY A 53  LEU A 61  1 ? 9  
HELX_P HELX_P4  AA4 ASN A 83  ? ASP A 104 ? ASN A 88  ASP A 109 1 ? 22 
HELX_P HELX_P5  AA5 ASP A 114 ? SER A 116 ? ASP A 119 SER A 121 5 ? 3  
HELX_P HELX_P6  AA6 LEU A 117 ? CYS A 129 ? LEU A 122 CYS A 134 1 ? 13 
HELX_P HELX_P7  AA7 ASN A 153 ? GLY A 156 ? ASN A 158 GLY A 161 5 ? 4  
HELX_P HELX_P8  AA8 GLN A 157 ? LEU A 163 ? GLN A 162 LEU A 168 1 ? 7  
HELX_P HELX_P9  AA9 ARG A 164 ? VAL A 170 ? ARG A 169 VAL A 175 5 ? 7  
HELX_P HELX_P10 AB1 SER A 184 ? ALA A 186 ? SER A 189 ALA A 191 5 ? 3  
HELX_P HELX_P11 AB2 ASP A 197 ? TYR A 207 ? ASP A 202 TYR A 212 1 ? 11 
HELX_P HELX_P12 AB3 MET A 214 ? GLY A 221 ? MET A 219 GLY A 226 1 ? 8  
HELX_P HELX_P13 AB4 GLY A 221 ? GLY A 235 ? GLY A 226 GLY A 240 1 ? 15 
HELX_P HELX_P14 AB5 ASP A 248 ? PHE A 250 ? ASP A 253 PHE A 255 5 ? 3  
HELX_P HELX_P15 AB6 THR A 267 ? THR A 281 ? THR A 272 THR A 286 1 ? 15 
HELX_P HELX_P16 AB7 ASN A 293 ? ALA A 297 ? ASN A 298 ALA A 302 5 ? 5  
HELX_P HELX_P17 AB8 SER A 299 ? PHE A 318 ? SER A 304 PHE A 323 1 ? 20 
HELX_P HELX_P18 AB9 GLY B 36  ? GLU B 38  ? GLY B 41  GLU B 43  5 ? 3  
HELX_P HELX_P19 AC1 HIS B 39  ? ALA B 47  ? HIS B 44  ALA B 52  1 ? 9  
HELX_P HELX_P20 AC2 GLY B 48  ? LEU B 56  ? GLY B 53  LEU B 61  1 ? 9  
HELX_P HELX_P21 AC3 ASN B 83  ? ASP B 104 ? ASN B 88  ASP B 109 1 ? 22 
HELX_P HELX_P22 AC4 ASP B 114 ? SER B 116 ? ASP B 119 SER B 121 5 ? 3  
HELX_P HELX_P23 AC5 LEU B 117 ? CYS B 129 ? LEU B 122 CYS B 134 1 ? 13 
HELX_P HELX_P24 AC6 ASN B 153 ? GLY B 156 ? ASN B 158 GLY B 161 5 ? 4  
HELX_P HELX_P25 AC7 GLN B 157 ? LEU B 163 ? GLN B 162 LEU B 168 1 ? 7  
HELX_P HELX_P26 AC8 ARG B 164 ? VAL B 170 ? ARG B 169 VAL B 175 5 ? 7  
HELX_P HELX_P27 AC9 SER B 184 ? ALA B 186 ? SER B 189 ALA B 191 5 ? 3  
HELX_P HELX_P28 AD1 ASP B 197 ? TYR B 207 ? ASP B 202 TYR B 212 1 ? 11 
HELX_P HELX_P29 AD2 MET B 214 ? GLY B 221 ? MET B 219 GLY B 226 1 ? 8  
HELX_P HELX_P30 AD3 GLY B 221 ? GLY B 235 ? GLY B 226 GLY B 240 1 ? 15 
HELX_P HELX_P31 AD4 ASP B 248 ? PHE B 250 ? ASP B 253 PHE B 255 5 ? 3  
HELX_P HELX_P32 AD5 THR B 267 ? THR B 281 ? THR B 272 THR B 286 1 ? 15 
HELX_P HELX_P33 AD6 ASN B 293 ? ALA B 297 ? ASN B 298 ALA B 302 5 ? 5  
HELX_P HELX_P34 AD7 SER B 299 ? PHE B 318 ? SER B 304 PHE B 323 1 ? 20 
HELX_P HELX_P35 AD8 GLY C 36  ? GLU C 38  ? GLY C 41  GLU C 43  5 ? 3  
HELX_P HELX_P36 AD9 HIS C 39  ? ALA C 47  ? HIS C 44  ALA C 52  1 ? 9  
HELX_P HELX_P37 AE1 GLY C 48  ? LEU C 56  ? GLY C 53  LEU C 61  1 ? 9  
HELX_P HELX_P38 AE2 ASN C 83  ? ASP C 104 ? ASN C 88  ASP C 109 1 ? 22 
HELX_P HELX_P39 AE3 ASP C 114 ? SER C 116 ? ASP C 119 SER C 121 5 ? 3  
HELX_P HELX_P40 AE4 LEU C 117 ? ARG C 127 ? LEU C 122 ARG C 132 1 ? 11 
HELX_P HELX_P41 AE5 ASN C 153 ? GLY C 156 ? ASN C 158 GLY C 161 5 ? 4  
HELX_P HELX_P42 AE6 GLN C 157 ? LEU C 163 ? GLN C 162 LEU C 168 1 ? 7  
HELX_P HELX_P43 AE7 ARG C 164 ? VAL C 170 ? ARG C 169 VAL C 175 5 ? 7  
HELX_P HELX_P44 AE8 SER C 184 ? ALA C 186 ? SER C 189 ALA C 191 5 ? 3  
HELX_P HELX_P45 AE9 ASP C 197 ? TYR C 207 ? ASP C 202 TYR C 212 1 ? 11 
HELX_P HELX_P46 AF1 SER C 213 ? GLY C 221 ? SER C 218 GLY C 226 1 ? 9  
HELX_P HELX_P47 AF2 GLY C 221 ? GLY C 235 ? GLY C 226 GLY C 240 1 ? 15 
HELX_P HELX_P48 AF3 ASP C 248 ? PHE C 250 ? ASP C 253 PHE C 255 5 ? 3  
HELX_P HELX_P49 AF4 THR C 267 ? THR C 281 ? THR C 272 THR C 286 1 ? 15 
HELX_P HELX_P50 AF5 ASN C 293 ? ALA C 297 ? ASN C 298 ALA C 302 5 ? 5  
HELX_P HELX_P51 AF6 SER C 299 ? PHE C 318 ? SER C 304 PHE C 323 1 ? 20 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1  metalc ? ? A HIS 115 ND1 ? ? ? 1_555 D MN  . MN ? ? A HIS 120 A MN  401 1_555 ? ? ? ? ? ? ? 2.217 ? ? 
metalc2  metalc ? ? A ASP 138 OD2 ? ? ? 1_555 D MN  . MN ? ? A ASP 143 A MN  401 1_555 ? ? ? ? ? ? ? 2.224 ? ? 
metalc3  metalc ? ? A ASP 138 OD1 ? ? ? 1_555 E MN  . MN ? ? A ASP 143 A MN  402 1_555 ? ? ? ? ? ? ? 2.128 ? ? 
metalc4  metalc ? ? A HIS 140 ND1 ? ? ? 1_555 E MN  . MN ? ? A HIS 145 A MN  402 1_555 ? ? ? ? ? ? ? 2.299 ? ? 
metalc5  metalc ? ? A ASP 142 OD2 ? ? ? 1_555 D MN  . MN ? ? A ASP 147 A MN  401 1_555 ? ? ? ? ? ? ? 2.196 ? ? 
metalc6  metalc ? ? A ASP 246 OD2 ? ? ? 1_555 D MN  . MN ? ? A ASP 251 A MN  401 1_555 ? ? ? ? ? ? ? 2.358 ? ? 
metalc7  metalc ? ? A ASP 246 OD2 ? ? ? 1_555 E MN  . MN ? ? A ASP 251 A MN  402 1_555 ? ? ? ? ? ? ? 2.165 ? ? 
metalc8  metalc ? ? A ASP 248 OD1 ? ? ? 1_555 E MN  . MN ? ? A ASP 253 A MN  402 1_555 ? ? ? ? ? ? ? 2.319 ? ? 
metalc9  metalc ? ? A ASP 248 OD2 ? ? ? 1_555 E MN  . MN ? ? A ASP 253 A MN  402 1_555 ? ? ? ? ? ? ? 2.231 ? ? 
metalc10 metalc ? ? D MN  .   MN  ? ? ? 1_555 F DMS . S  ? ? A MN  401 A DMS 403 1_555 ? ? ? ? ? ? ? 2.774 ? ? 
metalc11 metalc ? ? D MN  .   MN  ? ? ? 1_555 F DMS . O  ? ? A MN  401 A DMS 403 1_555 ? ? ? ? ? ? ? 2.200 ? ? 
metalc12 metalc ? ? E MN  .   MN  ? ? ? 1_555 F DMS . O  ? ? A MN  402 A DMS 403 1_555 ? ? ? ? ? ? ? 1.995 ? ? 
metalc13 metalc ? ? B HIS 115 ND1 ? ? ? 1_555 I MN  . MN ? ? B HIS 120 B MN  401 1_555 ? ? ? ? ? ? ? 2.306 ? ? 
metalc14 metalc ? ? B ASP 138 OD2 ? ? ? 1_555 I MN  . MN ? ? B ASP 143 B MN  401 1_555 ? ? ? ? ? ? ? 2.206 ? ? 
metalc15 metalc ? ? B ASP 138 OD1 ? ? ? 1_555 J MN  . MN ? ? B ASP 143 B MN  402 1_555 ? ? ? ? ? ? ? 2.086 ? ? 
metalc16 metalc ? ? B HIS 140 ND1 ? ? ? 1_555 J MN  . MN ? ? B HIS 145 B MN  402 1_555 ? ? ? ? ? ? ? 2.331 ? ? 
metalc17 metalc ? ? B ASP 142 OD2 ? ? ? 1_555 I MN  . MN ? ? B ASP 147 B MN  401 1_555 ? ? ? ? ? ? ? 2.234 ? ? 
metalc18 metalc ? ? B ASP 246 OD2 ? ? ? 1_555 I MN  . MN ? ? B ASP 251 B MN  401 1_555 ? ? ? ? ? ? ? 2.340 ? ? 
metalc19 metalc ? ? B ASP 246 OD2 ? ? ? 1_555 J MN  . MN ? ? B ASP 251 B MN  402 1_555 ? ? ? ? ? ? ? 2.203 ? ? 
metalc20 metalc ? ? B ASP 248 OD1 ? ? ? 1_555 J MN  . MN ? ? B ASP 253 B MN  402 1_555 ? ? ? ? ? ? ? 2.419 ? ? 
metalc21 metalc ? ? B ASP 248 OD2 ? ? ? 1_555 J MN  . MN ? ? B ASP 253 B MN  402 1_555 ? ? ? ? ? ? ? 2.261 ? ? 
metalc22 metalc ? ? I MN  .   MN  ? ? ? 1_555 K DMS . O  ? ? B MN  401 B DMS 403 1_555 ? ? ? ? ? ? ? 2.263 ? ? 
metalc23 metalc ? ? J MN  .   MN  ? ? ? 1_555 K DMS . O  ? ? B MN  402 B DMS 403 1_555 ? ? ? ? ? ? ? 2.413 ? ? 
metalc24 metalc ? ? C HIS 115 ND1 ? ? ? 1_555 N MN  . MN ? ? C HIS 120 C MN  401 1_555 ? ? ? ? ? ? ? 2.226 ? ? 
metalc25 metalc ? ? C ASP 138 OD2 ? ? ? 1_555 N MN  . MN ? ? C ASP 143 C MN  401 1_555 ? ? ? ? ? ? ? 2.270 ? ? 
metalc26 metalc ? ? C ASP 138 OD1 ? ? ? 1_555 O MN  . MN ? ? C ASP 143 C MN  402 1_555 ? ? ? ? ? ? ? 2.109 ? ? 
metalc27 metalc ? ? C HIS 140 ND1 ? ? ? 1_555 O MN  . MN ? ? C HIS 145 C MN  402 1_555 ? ? ? ? ? ? ? 2.375 ? ? 
metalc28 metalc ? ? C ASP 142 OD2 ? ? ? 1_555 N MN  . MN ? ? C ASP 147 C MN  401 1_555 ? ? ? ? ? ? ? 2.068 ? ? 
metalc29 metalc ? ? C ASP 246 OD2 ? ? ? 1_555 N MN  . MN ? ? C ASP 251 C MN  401 1_555 ? ? ? ? ? ? ? 2.608 ? ? 
metalc30 metalc ? ? C ASP 246 OD2 ? ? ? 1_555 O MN  . MN ? ? C ASP 251 C MN  402 1_555 ? ? ? ? ? ? ? 2.067 ? ? 
metalc31 metalc ? ? C ASP 248 OD1 ? ? ? 1_555 O MN  . MN ? ? C ASP 253 C MN  402 1_555 ? ? ? ? ? ? ? 2.391 ? ? 
metalc32 metalc ? ? C ASP 248 OD2 ? ? ? 1_555 O MN  . MN ? ? C ASP 253 C MN  402 1_555 ? ? ? ? ? ? ? 2.366 ? ? 
metalc33 metalc ? ? N MN  .   MN  ? ? ? 1_555 P DMS . S  ? ? C MN  401 C DMS 403 1_555 ? ? ? ? ? ? ? 2.782 ? ? 
metalc34 metalc ? ? N MN  .   MN  ? ? ? 1_555 P DMS . O  ? ? C MN  401 C DMS 403 1_555 ? ? ? ? ? ? ? 2.068 ? ? 
metalc35 metalc ? ? O MN  .   MN  ? ? ? 1_555 P DMS . O  ? ? C MN  402 C DMS 403 1_555 ? ? ? ? ? ? ? 2.089 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  ND1 ? A HIS 115 ? A HIS 120 ? 1_555 MN ? D MN . ? A MN 401 ? 1_555 OD2 ? A ASP 138 ? A ASP 143 ? 1_555 84.9  ? 
2  ND1 ? A HIS 115 ? A HIS 120 ? 1_555 MN ? D MN . ? A MN 401 ? 1_555 OD2 ? A ASP 142 ? A ASP 147 ? 1_555 91.5  ? 
3  OD2 ? A ASP 138 ? A ASP 143 ? 1_555 MN ? D MN . ? A MN 401 ? 1_555 OD2 ? A ASP 142 ? A ASP 147 ? 1_555 87.1  ? 
4  ND1 ? A HIS 115 ? A HIS 120 ? 1_555 MN ? D MN . ? A MN 401 ? 1_555 OD2 ? A ASP 246 ? A ASP 251 ? 1_555 102.5 ? 
5  OD2 ? A ASP 138 ? A ASP 143 ? 1_555 MN ? D MN . ? A MN 401 ? 1_555 OD2 ? A ASP 246 ? A ASP 251 ? 1_555 84.4  ? 
6  OD2 ? A ASP 142 ? A ASP 147 ? 1_555 MN ? D MN . ? A MN 401 ? 1_555 OD2 ? A ASP 246 ? A ASP 251 ? 1_555 162.8 ? 
7  ND1 ? A HIS 115 ? A HIS 120 ? 1_555 MN ? D MN . ? A MN 401 ? 1_555 S   ? F DMS .   ? A DMS 403 ? 1_555 142.9 ? 
8  OD2 ? A ASP 138 ? A ASP 143 ? 1_555 MN ? D MN . ? A MN 401 ? 1_555 S   ? F DMS .   ? A DMS 403 ? 1_555 132.2 ? 
9  OD2 ? A ASP 142 ? A ASP 147 ? 1_555 MN ? D MN . ? A MN 401 ? 1_555 S   ? F DMS .   ? A DMS 403 ? 1_555 90.0  ? 
10 OD2 ? A ASP 246 ? A ASP 251 ? 1_555 MN ? D MN . ? A MN 401 ? 1_555 S   ? F DMS .   ? A DMS 403 ? 1_555 84.7  ? 
11 ND1 ? A HIS 115 ? A HIS 120 ? 1_555 MN ? D MN . ? A MN 401 ? 1_555 O   ? F DMS .   ? A DMS 403 ? 1_555 176.8 ? 
12 OD2 ? A ASP 138 ? A ASP 143 ? 1_555 MN ? D MN . ? A MN 401 ? 1_555 O   ? F DMS .   ? A DMS 403 ? 1_555 92.1  ? 
13 OD2 ? A ASP 142 ? A ASP 147 ? 1_555 MN ? D MN . ? A MN 401 ? 1_555 O   ? F DMS .   ? A DMS 403 ? 1_555 87.1  ? 
14 OD2 ? A ASP 246 ? A ASP 251 ? 1_555 MN ? D MN . ? A MN 401 ? 1_555 O   ? F DMS .   ? A DMS 403 ? 1_555 78.3  ? 
15 S   ? F DMS .   ? A DMS 403 ? 1_555 MN ? D MN . ? A MN 401 ? 1_555 O   ? F DMS .   ? A DMS 403 ? 1_555 40.1  ? 
16 OD1 ? A ASP 138 ? A ASP 143 ? 1_555 MN ? E MN . ? A MN 402 ? 1_555 ND1 ? A HIS 140 ? A HIS 145 ? 1_555 94.9  ? 
17 OD1 ? A ASP 138 ? A ASP 143 ? 1_555 MN ? E MN . ? A MN 402 ? 1_555 OD2 ? A ASP 246 ? A ASP 251 ? 1_555 93.5  ? 
18 ND1 ? A HIS 140 ? A HIS 145 ? 1_555 MN ? E MN . ? A MN 402 ? 1_555 OD2 ? A ASP 246 ? A ASP 251 ? 1_555 166.5 ? 
19 OD1 ? A ASP 138 ? A ASP 143 ? 1_555 MN ? E MN . ? A MN 402 ? 1_555 OD1 ? A ASP 248 ? A ASP 253 ? 1_555 84.6  ? 
20 ND1 ? A HIS 140 ? A HIS 145 ? 1_555 MN ? E MN . ? A MN 402 ? 1_555 OD1 ? A ASP 248 ? A ASP 253 ? 1_555 102.3 ? 
21 OD2 ? A ASP 246 ? A ASP 251 ? 1_555 MN ? E MN . ? A MN 402 ? 1_555 OD1 ? A ASP 248 ? A ASP 253 ? 1_555 89.0  ? 
22 OD1 ? A ASP 138 ? A ASP 143 ? 1_555 MN ? E MN . ? A MN 402 ? 1_555 OD2 ? A ASP 248 ? A ASP 253 ? 1_555 142.8 ? 
23 ND1 ? A HIS 140 ? A HIS 145 ? 1_555 MN ? E MN . ? A MN 402 ? 1_555 OD2 ? A ASP 248 ? A ASP 253 ? 1_555 92.1  ? 
24 OD2 ? A ASP 246 ? A ASP 251 ? 1_555 MN ? E MN . ? A MN 402 ? 1_555 OD2 ? A ASP 248 ? A ASP 253 ? 1_555 87.6  ? 
25 OD1 ? A ASP 248 ? A ASP 253 ? 1_555 MN ? E MN . ? A MN 402 ? 1_555 OD2 ? A ASP 248 ? A ASP 253 ? 1_555 58.2  ? 
26 OD1 ? A ASP 138 ? A ASP 143 ? 1_555 MN ? E MN . ? A MN 402 ? 1_555 O   ? F DMS .   ? A DMS 403 ? 1_555 91.0  ? 
27 ND1 ? A HIS 140 ? A HIS 145 ? 1_555 MN ? E MN . ? A MN 402 ? 1_555 O   ? F DMS .   ? A DMS 403 ? 1_555 81.7  ? 
28 OD2 ? A ASP 246 ? A ASP 251 ? 1_555 MN ? E MN . ? A MN 402 ? 1_555 O   ? F DMS .   ? A DMS 403 ? 1_555 87.6  ? 
29 OD1 ? A ASP 248 ? A ASP 253 ? 1_555 MN ? E MN . ? A MN 402 ? 1_555 O   ? F DMS .   ? A DMS 403 ? 1_555 174.3 ? 
30 OD2 ? A ASP 248 ? A ASP 253 ? 1_555 MN ? E MN . ? A MN 402 ? 1_555 O   ? F DMS .   ? A DMS 403 ? 1_555 126.2 ? 
31 ND1 ? B HIS 115 ? B HIS 120 ? 1_555 MN ? I MN . ? B MN 401 ? 1_555 OD2 ? B ASP 138 ? B ASP 143 ? 1_555 86.9  ? 
32 ND1 ? B HIS 115 ? B HIS 120 ? 1_555 MN ? I MN . ? B MN 401 ? 1_555 OD2 ? B ASP 142 ? B ASP 147 ? 1_555 89.8  ? 
33 OD2 ? B ASP 138 ? B ASP 143 ? 1_555 MN ? I MN . ? B MN 401 ? 1_555 OD2 ? B ASP 142 ? B ASP 147 ? 1_555 80.2  ? 
34 ND1 ? B HIS 115 ? B HIS 120 ? 1_555 MN ? I MN . ? B MN 401 ? 1_555 OD2 ? B ASP 246 ? B ASP 251 ? 1_555 102.8 ? 
35 OD2 ? B ASP 138 ? B ASP 143 ? 1_555 MN ? I MN . ? B MN 401 ? 1_555 OD2 ? B ASP 246 ? B ASP 251 ? 1_555 91.3  ? 
36 OD2 ? B ASP 142 ? B ASP 147 ? 1_555 MN ? I MN . ? B MN 401 ? 1_555 OD2 ? B ASP 246 ? B ASP 251 ? 1_555 164.5 ? 
37 ND1 ? B HIS 115 ? B HIS 120 ? 1_555 MN ? I MN . ? B MN 401 ? 1_555 O   ? K DMS .   ? B DMS 403 ? 1_555 165.2 ? 
38 OD2 ? B ASP 138 ? B ASP 143 ? 1_555 MN ? I MN . ? B MN 401 ? 1_555 O   ? K DMS .   ? B DMS 403 ? 1_555 97.0  ? 
39 OD2 ? B ASP 142 ? B ASP 147 ? 1_555 MN ? I MN . ? B MN 401 ? 1_555 O   ? K DMS .   ? B DMS 403 ? 1_555 76.9  ? 
40 OD2 ? B ASP 246 ? B ASP 251 ? 1_555 MN ? I MN . ? B MN 401 ? 1_555 O   ? K DMS .   ? B DMS 403 ? 1_555 91.4  ? 
41 OD1 ? B ASP 138 ? B ASP 143 ? 1_555 MN ? J MN . ? B MN 402 ? 1_555 ND1 ? B HIS 140 ? B HIS 145 ? 1_555 97.4  ? 
42 OD1 ? B ASP 138 ? B ASP 143 ? 1_555 MN ? J MN . ? B MN 402 ? 1_555 OD2 ? B ASP 246 ? B ASP 251 ? 1_555 91.8  ? 
43 ND1 ? B HIS 140 ? B HIS 145 ? 1_555 MN ? J MN . ? B MN 402 ? 1_555 OD2 ? B ASP 246 ? B ASP 251 ? 1_555 168.5 ? 
44 OD1 ? B ASP 138 ? B ASP 143 ? 1_555 MN ? J MN . ? B MN 402 ? 1_555 OD1 ? B ASP 248 ? B ASP 253 ? 1_555 85.0  ? 
45 ND1 ? B HIS 140 ? B HIS 145 ? 1_555 MN ? J MN . ? B MN 402 ? 1_555 OD1 ? B ASP 248 ? B ASP 253 ? 1_555 101.1 ? 
46 OD2 ? B ASP 246 ? B ASP 251 ? 1_555 MN ? J MN . ? B MN 402 ? 1_555 OD1 ? B ASP 248 ? B ASP 253 ? 1_555 86.6  ? 
47 OD1 ? B ASP 138 ? B ASP 143 ? 1_555 MN ? J MN . ? B MN 402 ? 1_555 OD2 ? B ASP 248 ? B ASP 253 ? 1_555 140.1 ? 
48 ND1 ? B HIS 140 ? B HIS 145 ? 1_555 MN ? J MN . ? B MN 402 ? 1_555 OD2 ? B ASP 248 ? B ASP 253 ? 1_555 88.2  ? 
49 OD2 ? B ASP 246 ? B ASP 251 ? 1_555 MN ? J MN . ? B MN 402 ? 1_555 OD2 ? B ASP 248 ? B ASP 253 ? 1_555 89.2  ? 
50 OD1 ? B ASP 248 ? B ASP 253 ? 1_555 MN ? J MN . ? B MN 402 ? 1_555 OD2 ? B ASP 248 ? B ASP 253 ? 1_555 55.3  ? 
51 OD1 ? B ASP 138 ? B ASP 143 ? 1_555 MN ? J MN . ? B MN 402 ? 1_555 O   ? K DMS .   ? B DMS 403 ? 1_555 91.7  ? 
52 ND1 ? B HIS 140 ? B HIS 145 ? 1_555 MN ? J MN . ? B MN 402 ? 1_555 O   ? K DMS .   ? B DMS 403 ? 1_555 81.8  ? 
53 OD2 ? B ASP 246 ? B ASP 251 ? 1_555 MN ? J MN . ? B MN 402 ? 1_555 O   ? K DMS .   ? B DMS 403 ? 1_555 91.0  ? 
54 OD1 ? B ASP 248 ? B ASP 253 ? 1_555 MN ? J MN . ? B MN 402 ? 1_555 O   ? K DMS .   ? B DMS 403 ? 1_555 175.9 ? 
55 OD2 ? B ASP 248 ? B ASP 253 ? 1_555 MN ? J MN . ? B MN 402 ? 1_555 O   ? K DMS .   ? B DMS 403 ? 1_555 128.1 ? 
56 ND1 ? C HIS 115 ? C HIS 120 ? 1_555 MN ? N MN . ? C MN 401 ? 1_555 OD2 ? C ASP 138 ? C ASP 143 ? 1_555 80.7  ? 
57 ND1 ? C HIS 115 ? C HIS 120 ? 1_555 MN ? N MN . ? C MN 401 ? 1_555 OD2 ? C ASP 142 ? C ASP 147 ? 1_555 100.3 ? 
58 OD2 ? C ASP 138 ? C ASP 143 ? 1_555 MN ? N MN . ? C MN 401 ? 1_555 OD2 ? C ASP 142 ? C ASP 147 ? 1_555 89.0  ? 
59 ND1 ? C HIS 115 ? C HIS 120 ? 1_555 MN ? N MN . ? C MN 401 ? 1_555 OD2 ? C ASP 246 ? C ASP 251 ? 1_555 94.9  ? 
60 OD2 ? C ASP 138 ? C ASP 143 ? 1_555 MN ? N MN . ? C MN 401 ? 1_555 OD2 ? C ASP 246 ? C ASP 251 ? 1_555 83.3  ? 
61 OD2 ? C ASP 142 ? C ASP 147 ? 1_555 MN ? N MN . ? C MN 401 ? 1_555 OD2 ? C ASP 246 ? C ASP 251 ? 1_555 161.6 ? 
62 ND1 ? C HIS 115 ? C HIS 120 ? 1_555 MN ? N MN . ? C MN 401 ? 1_555 S   ? P DMS .   ? C DMS 403 ? 1_555 139.8 ? 
63 OD2 ? C ASP 138 ? C ASP 143 ? 1_555 MN ? N MN . ? C MN 401 ? 1_555 S   ? P DMS .   ? C DMS 403 ? 1_555 138.5 ? 
64 OD2 ? C ASP 142 ? C ASP 147 ? 1_555 MN ? N MN . ? C MN 401 ? 1_555 S   ? P DMS .   ? C DMS 403 ? 1_555 90.8  ? 
65 OD2 ? C ASP 246 ? C ASP 251 ? 1_555 MN ? N MN . ? C MN 401 ? 1_555 S   ? P DMS .   ? C DMS 403 ? 1_555 84.0  ? 
66 ND1 ? C HIS 115 ? C HIS 120 ? 1_555 MN ? N MN . ? C MN 401 ? 1_555 O   ? P DMS .   ? C DMS 403 ? 1_555 175.1 ? 
67 OD2 ? C ASP 138 ? C ASP 143 ? 1_555 MN ? N MN . ? C MN 401 ? 1_555 O   ? P DMS .   ? C DMS 403 ? 1_555 98.9  ? 
68 OD2 ? C ASP 142 ? C ASP 147 ? 1_555 MN ? N MN . ? C MN 401 ? 1_555 O   ? P DMS .   ? C DMS 403 ? 1_555 84.6  ? 
69 OD2 ? C ASP 246 ? C ASP 251 ? 1_555 MN ? N MN . ? C MN 401 ? 1_555 O   ? P DMS .   ? C DMS 403 ? 1_555 80.2  ? 
70 S   ? P DMS .   ? C DMS 403 ? 1_555 MN ? N MN . ? C MN 401 ? 1_555 O   ? P DMS .   ? C DMS 403 ? 1_555 39.8  ? 
71 OD1 ? C ASP 138 ? C ASP 143 ? 1_555 MN ? O MN . ? C MN 402 ? 1_555 ND1 ? C HIS 140 ? C HIS 145 ? 1_555 96.7  ? 
72 OD1 ? C ASP 138 ? C ASP 143 ? 1_555 MN ? O MN . ? C MN 402 ? 1_555 OD2 ? C ASP 246 ? C ASP 251 ? 1_555 91.7  ? 
73 ND1 ? C HIS 140 ? C HIS 145 ? 1_555 MN ? O MN . ? C MN 402 ? 1_555 OD2 ? C ASP 246 ? C ASP 251 ? 1_555 170.0 ? 
74 OD1 ? C ASP 138 ? C ASP 143 ? 1_555 MN ? O MN . ? C MN 402 ? 1_555 OD1 ? C ASP 248 ? C ASP 253 ? 1_555 83.4  ? 
75 ND1 ? C HIS 140 ? C HIS 145 ? 1_555 MN ? O MN . ? C MN 402 ? 1_555 OD1 ? C ASP 248 ? C ASP 253 ? 1_555 101.1 ? 
76 OD2 ? C ASP 246 ? C ASP 251 ? 1_555 MN ? O MN . ? C MN 402 ? 1_555 OD1 ? C ASP 248 ? C ASP 253 ? 1_555 85.3  ? 
77 OD1 ? C ASP 138 ? C ASP 143 ? 1_555 MN ? O MN . ? C MN 402 ? 1_555 OD2 ? C ASP 248 ? C ASP 253 ? 1_555 138.8 ? 
78 ND1 ? C HIS 140 ? C HIS 145 ? 1_555 MN ? O MN . ? C MN 402 ? 1_555 OD2 ? C ASP 248 ? C ASP 253 ? 1_555 90.4  ? 
79 OD2 ? C ASP 246 ? C ASP 251 ? 1_555 MN ? O MN . ? C MN 402 ? 1_555 OD2 ? C ASP 248 ? C ASP 253 ? 1_555 86.9  ? 
80 OD1 ? C ASP 248 ? C ASP 253 ? 1_555 MN ? O MN . ? C MN 402 ? 1_555 OD2 ? C ASP 248 ? C ASP 253 ? 1_555 55.5  ? 
81 OD1 ? C ASP 138 ? C ASP 143 ? 1_555 MN ? O MN . ? C MN 402 ? 1_555 O   ? P DMS .   ? C DMS 403 ? 1_555 93.6  ? 
82 ND1 ? C HIS 140 ? C HIS 145 ? 1_555 MN ? O MN . ? C MN 402 ? 1_555 O   ? P DMS .   ? C DMS 403 ? 1_555 80.1  ? 
83 OD2 ? C ASP 246 ? C ASP 251 ? 1_555 MN ? O MN . ? C MN 402 ? 1_555 O   ? P DMS .   ? C DMS 403 ? 1_555 94.0  ? 
84 OD1 ? C ASP 248 ? C ASP 253 ? 1_555 MN ? O MN . ? C MN 402 ? 1_555 O   ? P DMS .   ? C DMS 403 ? 1_555 176.9 ? 
85 OD2 ? C ASP 248 ? C ASP 253 ? 1_555 MN ? O MN . ? C MN 402 ? 1_555 O   ? P DMS .   ? C DMS 403 ? 1_555 127.6 ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 GLY 112 A . ? GLY 117 A GLY 113 A ? GLY 118 A 1 4.76 
2 GLY 112 B . ? GLY 117 B GLY 113 B ? GLY 118 B 1 5.02 
3 GLY 112 C . ? GLY 117 C GLY 113 C ? GLY 118 C 1 1.99 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 8 ? 
AA2 ? 8 ? 
AA3 ? 8 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel 
AA1 2 3 ? parallel 
AA1 3 4 ? parallel 
AA1 4 5 ? parallel 
AA1 5 6 ? parallel 
AA1 6 7 ? parallel 
AA1 7 8 ? parallel 
AA2 1 2 ? parallel 
AA2 2 3 ? parallel 
AA2 3 4 ? parallel 
AA2 4 5 ? parallel 
AA2 5 6 ? parallel 
AA2 6 7 ? parallel 
AA2 7 8 ? parallel 
AA3 1 2 ? parallel 
AA3 2 3 ? parallel 
AA3 3 4 ? parallel 
AA3 4 5 ? parallel 
AA3 5 6 ? parallel 
AA3 6 7 ? parallel 
AA3 7 8 ? parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 HIS A 59  ? ASP A 65  ? HIS A 64  ASP A 70  
AA1 2 SER A 20  ? ALA A 26  ? SER A 25  ALA A 31  
AA1 3 SER A 107 ? GLY A 112 ? SER A 112 GLY A 117 
AA1 4 LEU A 284 ? VAL A 290 ? LEU A 289 VAL A 295 
AA1 5 ILE A 241 ? ASP A 246 ? ILE A 246 ASP A 251 
AA1 6 CYS A 133 ? VAL A 137 ? CYS A 138 VAL A 142 
AA1 7 ILE A 188 ? LEU A 193 ? ILE A 193 LEU A 198 
AA1 8 GLN A 210 ? SER A 213 ? GLN A 215 SER A 218 
AA2 1 HIS B 59  ? ASP B 65  ? HIS B 64  ASP B 70  
AA2 2 SER B 20  ? ALA B 26  ? SER B 25  ALA B 31  
AA2 3 SER B 107 ? GLY B 112 ? SER B 112 GLY B 117 
AA2 4 LEU B 284 ? VAL B 290 ? LEU B 289 VAL B 295 
AA2 5 ILE B 241 ? ASP B 246 ? ILE B 246 ASP B 251 
AA2 6 CYS B 133 ? VAL B 137 ? CYS B 138 VAL B 142 
AA2 7 ILE B 188 ? LEU B 193 ? ILE B 193 LEU B 198 
AA2 8 GLN B 210 ? SER B 213 ? GLN B 215 SER B 218 
AA3 1 HIS C 59  ? ASP C 65  ? HIS C 64  ASP C 70  
AA3 2 SER C 20  ? GLY C 25  ? SER C 25  GLY C 30  
AA3 3 SER C 107 ? LEU C 111 ? SER C 112 LEU C 116 
AA3 4 LEU C 284 ? VAL C 290 ? LEU C 289 VAL C 295 
AA3 5 ILE C 241 ? ASP C 246 ? ILE C 246 ASP C 251 
AA3 6 CYS C 133 ? VAL C 137 ? CYS C 138 VAL C 142 
AA3 7 ILE C 188 ? ILE C 191 ? ILE C 193 ILE C 196 
AA3 8 GLN C 210 ? PHE C 212 ? GLN C 215 PHE C 217 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O PHE A 63  ? O PHE A 68  N VAL A 23  ? N VAL A 28  
AA1 2 3 N ALA A 22  ? N ALA A 27  O VAL A 109 ? O VAL A 114 
AA1 3 4 N THR A 110 ? N THR A 115 O LEU A 287 ? O LEU A 292 
AA1 4 5 O SER A 285 ? O SER A 290 N ILE A 241 ? N ILE A 246 
AA1 5 6 O ASP A 246 ? O ASP A 251 N VAL A 137 ? N VAL A 142 
AA1 6 7 N TRP A 136 ? N TRP A 141 O VAL A 189 ? O VAL A 194 
AA1 7 8 N GLY A 192 ? N GLY A 197 O PHE A 212 ? O PHE A 217 
AA2 1 2 O PHE B 63  ? O PHE B 68  N VAL B 23  ? N VAL B 28  
AA2 2 3 N ALA B 22  ? N ALA B 27  O VAL B 109 ? O VAL B 114 
AA2 3 4 N THR B 110 ? N THR B 115 O LEU B 287 ? O LEU B 292 
AA2 4 5 O ASP B 288 ? O ASP B 293 N LEU B 243 ? N LEU B 248 
AA2 5 6 O ASP B 246 ? O ASP B 251 N VAL B 137 ? N VAL B 142 
AA2 6 7 N TRP B 136 ? N TRP B 141 O VAL B 189 ? O VAL B 194 
AA2 7 8 N GLY B 192 ? N GLY B 197 O PHE B 212 ? O PHE B 217 
AA3 1 2 O HIS C 59  ? O HIS C 64  N VAL C 21  ? N VAL C 26  
AA3 2 3 N ILE C 24  ? N ILE C 29  O VAL C 109 ? O VAL C 114 
AA3 3 4 N CYS C 108 ? N CYS C 113 O LEU C 287 ? O LEU C 292 
AA3 4 5 O SER C 285 ? O SER C 290 N ILE C 241 ? N ILE C 246 
AA3 5 6 O ASP C 246 ? O ASP C 251 N VAL C 137 ? N VAL C 142 
AA3 6 7 N TRP C 136 ? N TRP C 141 O VAL C 189 ? O VAL C 194 
AA3 7 8 N TYR C 190 ? N TYR C 195 O PHE C 212 ? O PHE C 217 
# 
_pdbx_entry_details.entry_id                   8RGU 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 OD2 C ASP 200 ? ? O C HOH 501 ? ? 2.11 
2 1 O   B HOH 582 ? ? O B HOH 599 ? ? 2.17 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 PRO A 32  ? ? -79.14  49.34  
2  1 LEU A 85  ? ? -135.53 -54.83 
3  1 ASP A 143 ? ? -174.21 144.66 
4  1 ARG A 199 ? ? -151.94 -1.34  
5  1 LEU B 81  ? ? -49.48  154.85 
6  1 LEU B 85  ? ? -134.32 -69.94 
7  1 ASP B 143 ? ? -170.64 147.76 
8  1 ARG B 199 ? ? -150.89 -2.44  
9  1 ASP C 79  ? ? -177.96 57.89  
10 1 ASN C 84  ? ? 52.05   19.28  
11 1 LEU C 85  ? ? -133.43 -59.79 
12 1 ASP C 143 ? ? -170.46 144.37 
13 1 ARG C 199 ? ? -154.58 -10.98 
14 1 GLU C 328 ? ? -140.29 13.48  
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      C 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       636 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   5.86 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 6   ? A MET 1   
2  1 Y 1 A HIS 7   ? A HIS 2   
3  1 Y 1 A HIS 8   ? A HIS 3   
4  1 Y 1 A HIS 9   ? A HIS 4   
5  1 Y 1 A HIS 10  ? A HIS 5   
6  1 Y 1 A HIS 11  ? A HIS 6   
7  1 Y 1 A HIS 12  ? A HIS 7   
8  1 Y 1 A GLY 13  ? A GLY 8   
9  1 Y 1 A GLY 14  ? A GLY 9   
10 1 Y 1 A GLY 15  ? A GLY 10  
11 1 Y 1 A GLU 16  ? A GLU 11  
12 1 Y 1 A PHE 73  ? A PHE 68  
13 1 Y 1 A THR 74  ? A THR 69  
14 1 Y 1 A PRO 75  ? A PRO 70  
15 1 Y 1 A VAL 76  ? A VAL 71  
16 1 Y 1 A PRO 77  ? A PRO 72  
17 1 Y 1 A LYS 78  ? A LYS 73  
18 1 Y 1 A SER 341 ? A SER 336 
19 1 Y 1 B MET 6   ? B MET 1   
20 1 Y 1 B HIS 7   ? B HIS 2   
21 1 Y 1 B HIS 8   ? B HIS 3   
22 1 Y 1 B HIS 9   ? B HIS 4   
23 1 Y 1 B HIS 10  ? B HIS 5   
24 1 Y 1 B HIS 11  ? B HIS 6   
25 1 Y 1 B HIS 12  ? B HIS 7   
26 1 Y 1 B GLY 13  ? B GLY 8   
27 1 Y 1 B GLY 14  ? B GLY 9   
28 1 Y 1 B GLY 15  ? B GLY 10  
29 1 Y 1 B GLU 16  ? B GLU 11  
30 1 Y 1 B ASN 17  ? B ASN 12  
31 1 Y 1 B LEU 18  ? B LEU 13  
32 1 Y 1 B TYR 19  ? B TYR 14  
33 1 Y 1 B PHE 20  ? B PHE 15  
34 1 Y 1 B GLN 21  ? B GLN 16  
35 1 Y 1 B SER 22  ? B SER 17  
36 1 Y 1 B PRO 77  ? B PRO 72  
37 1 Y 1 B LYS 78  ? B LYS 73  
38 1 Y 1 B ASP 79  ? B ASP 74  
39 1 Y 1 C MET 6   ? C MET 1   
40 1 Y 1 C HIS 7   ? C HIS 2   
41 1 Y 1 C HIS 8   ? C HIS 3   
42 1 Y 1 C HIS 9   ? C HIS 4   
43 1 Y 1 C HIS 10  ? C HIS 5   
44 1 Y 1 C HIS 11  ? C HIS 6   
45 1 Y 1 C HIS 12  ? C HIS 7   
46 1 Y 1 C GLY 13  ? C GLY 8   
47 1 Y 1 C GLY 14  ? C GLY 9   
48 1 Y 1 C GLY 15  ? C GLY 10  
49 1 Y 1 C GLU 16  ? C GLU 11  
50 1 Y 1 C ASN 17  ? C ASN 12  
51 1 Y 1 C LEU 18  ? C LEU 13  
52 1 Y 1 C TYR 19  ? C TYR 14  
53 1 Y 1 C ILE 332 ? C ILE 327 
54 1 Y 1 C VAL 333 ? C VAL 328 
55 1 Y 1 C TYR 334 ? C TYR 329 
56 1 Y 1 C ASP 335 ? C ASP 330 
57 1 Y 1 C GLN 336 ? C GLN 331 
58 1 Y 1 C LEU 337 ? C LEU 332 
59 1 Y 1 C PRO 338 ? C PRO 333 
60 1 Y 1 C THR 339 ? C THR 334 
61 1 Y 1 C PRO 340 ? C PRO 335 
62 1 Y 1 C SER 341 ? C SER 336 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CYS N    N  N N 74  
CYS CA   C  N R 75  
CYS C    C  N N 76  
CYS O    O  N N 77  
CYS CB   C  N N 78  
CYS SG   S  N N 79  
CYS OXT  O  N N 80  
CYS H    H  N N 81  
CYS H2   H  N N 82  
CYS HA   H  N N 83  
CYS HB2  H  N N 84  
CYS HB3  H  N N 85  
CYS HG   H  N N 86  
CYS HXT  H  N N 87  
DMS S    S  N N 88  
DMS O    O  N N 89  
DMS C1   C  N N 90  
DMS C2   C  N N 91  
DMS H11  H  N N 92  
DMS H12  H  N N 93  
DMS H13  H  N N 94  
DMS H21  H  N N 95  
DMS H22  H  N N 96  
DMS H23  H  N N 97  
GLN N    N  N N 98  
GLN CA   C  N S 99  
GLN C    C  N N 100 
GLN O    O  N N 101 
GLN CB   C  N N 102 
GLN CG   C  N N 103 
GLN CD   C  N N 104 
GLN OE1  O  N N 105 
GLN NE2  N  N N 106 
GLN OXT  O  N N 107 
GLN H    H  N N 108 
GLN H2   H  N N 109 
GLN HA   H  N N 110 
GLN HB2  H  N N 111 
GLN HB3  H  N N 112 
GLN HG2  H  N N 113 
GLN HG3  H  N N 114 
GLN HE21 H  N N 115 
GLN HE22 H  N N 116 
GLN HXT  H  N N 117 
GLU N    N  N N 118 
GLU CA   C  N S 119 
GLU C    C  N N 120 
GLU O    O  N N 121 
GLU CB   C  N N 122 
GLU CG   C  N N 123 
GLU CD   C  N N 124 
GLU OE1  O  N N 125 
GLU OE2  O  N N 126 
GLU OXT  O  N N 127 
GLU H    H  N N 128 
GLU H2   H  N N 129 
GLU HA   H  N N 130 
GLU HB2  H  N N 131 
GLU HB3  H  N N 132 
GLU HG2  H  N N 133 
GLU HG3  H  N N 134 
GLU HE2  H  N N 135 
GLU HXT  H  N N 136 
GLY N    N  N N 137 
GLY CA   C  N N 138 
GLY C    C  N N 139 
GLY O    O  N N 140 
GLY OXT  O  N N 141 
GLY H    H  N N 142 
GLY H2   H  N N 143 
GLY HA2  H  N N 144 
GLY HA3  H  N N 145 
GLY HXT  H  N N 146 
HIS N    N  N N 147 
HIS CA   C  N S 148 
HIS C    C  N N 149 
HIS O    O  N N 150 
HIS CB   C  N N 151 
HIS CG   C  Y N 152 
HIS ND1  N  Y N 153 
HIS CD2  C  Y N 154 
HIS CE1  C  Y N 155 
HIS NE2  N  Y N 156 
HIS OXT  O  N N 157 
HIS H    H  N N 158 
HIS H2   H  N N 159 
HIS HA   H  N N 160 
HIS HB2  H  N N 161 
HIS HB3  H  N N 162 
HIS HD1  H  N N 163 
HIS HD2  H  N N 164 
HIS HE1  H  N N 165 
HIS HE2  H  N N 166 
HIS HXT  H  N N 167 
HOH O    O  N N 168 
HOH H1   H  N N 169 
HOH H2   H  N N 170 
ILE N    N  N N 171 
ILE CA   C  N S 172 
ILE C    C  N N 173 
ILE O    O  N N 174 
ILE CB   C  N S 175 
ILE CG1  C  N N 176 
ILE CG2  C  N N 177 
ILE CD1  C  N N 178 
ILE OXT  O  N N 179 
ILE H    H  N N 180 
ILE H2   H  N N 181 
ILE HA   H  N N 182 
ILE HB   H  N N 183 
ILE HG12 H  N N 184 
ILE HG13 H  N N 185 
ILE HG21 H  N N 186 
ILE HG22 H  N N 187 
ILE HG23 H  N N 188 
ILE HD11 H  N N 189 
ILE HD12 H  N N 190 
ILE HD13 H  N N 191 
ILE HXT  H  N N 192 
LEU N    N  N N 193 
LEU CA   C  N S 194 
LEU C    C  N N 195 
LEU O    O  N N 196 
LEU CB   C  N N 197 
LEU CG   C  N N 198 
LEU CD1  C  N N 199 
LEU CD2  C  N N 200 
LEU OXT  O  N N 201 
LEU H    H  N N 202 
LEU H2   H  N N 203 
LEU HA   H  N N 204 
LEU HB2  H  N N 205 
LEU HB3  H  N N 206 
LEU HG   H  N N 207 
LEU HD11 H  N N 208 
LEU HD12 H  N N 209 
LEU HD13 H  N N 210 
LEU HD21 H  N N 211 
LEU HD22 H  N N 212 
LEU HD23 H  N N 213 
LEU HXT  H  N N 214 
LYS N    N  N N 215 
LYS CA   C  N S 216 
LYS C    C  N N 217 
LYS O    O  N N 218 
LYS CB   C  N N 219 
LYS CG   C  N N 220 
LYS CD   C  N N 221 
LYS CE   C  N N 222 
LYS NZ   N  N N 223 
LYS OXT  O  N N 224 
LYS H    H  N N 225 
LYS H2   H  N N 226 
LYS HA   H  N N 227 
LYS HB2  H  N N 228 
LYS HB3  H  N N 229 
LYS HG2  H  N N 230 
LYS HG3  H  N N 231 
LYS HD2  H  N N 232 
LYS HD3  H  N N 233 
LYS HE2  H  N N 234 
LYS HE3  H  N N 235 
LYS HZ1  H  N N 236 
LYS HZ2  H  N N 237 
LYS HZ3  H  N N 238 
LYS HXT  H  N N 239 
MET N    N  N N 240 
MET CA   C  N S 241 
MET C    C  N N 242 
MET O    O  N N 243 
MET CB   C  N N 244 
MET CG   C  N N 245 
MET SD   S  N N 246 
MET CE   C  N N 247 
MET OXT  O  N N 248 
MET H    H  N N 249 
MET H2   H  N N 250 
MET HA   H  N N 251 
MET HB2  H  N N 252 
MET HB3  H  N N 253 
MET HG2  H  N N 254 
MET HG3  H  N N 255 
MET HE1  H  N N 256 
MET HE2  H  N N 257 
MET HE3  H  N N 258 
MET HXT  H  N N 259 
MN  MN   MN N N 260 
PHE N    N  N N 261 
PHE CA   C  N S 262 
PHE C    C  N N 263 
PHE O    O  N N 264 
PHE CB   C  N N 265 
PHE CG   C  Y N 266 
PHE CD1  C  Y N 267 
PHE CD2  C  Y N 268 
PHE CE1  C  Y N 269 
PHE CE2  C  Y N 270 
PHE CZ   C  Y N 271 
PHE OXT  O  N N 272 
PHE H    H  N N 273 
PHE H2   H  N N 274 
PHE HA   H  N N 275 
PHE HB2  H  N N 276 
PHE HB3  H  N N 277 
PHE HD1  H  N N 278 
PHE HD2  H  N N 279 
PHE HE1  H  N N 280 
PHE HE2  H  N N 281 
PHE HZ   H  N N 282 
PHE HXT  H  N N 283 
PRO N    N  N N 284 
PRO CA   C  N S 285 
PRO C    C  N N 286 
PRO O    O  N N 287 
PRO CB   C  N N 288 
PRO CG   C  N N 289 
PRO CD   C  N N 290 
PRO OXT  O  N N 291 
PRO H    H  N N 292 
PRO HA   H  N N 293 
PRO HB2  H  N N 294 
PRO HB3  H  N N 295 
PRO HG2  H  N N 296 
PRO HG3  H  N N 297 
PRO HD2  H  N N 298 
PRO HD3  H  N N 299 
PRO HXT  H  N N 300 
SER N    N  N N 301 
SER CA   C  N S 302 
SER C    C  N N 303 
SER O    O  N N 304 
SER CB   C  N N 305 
SER OG   O  N N 306 
SER OXT  O  N N 307 
SER H    H  N N 308 
SER H2   H  N N 309 
SER HA   H  N N 310 
SER HB2  H  N N 311 
SER HB3  H  N N 312 
SER HG   H  N N 313 
SER HXT  H  N N 314 
THR N    N  N N 315 
THR CA   C  N S 316 
THR C    C  N N 317 
THR O    O  N N 318 
THR CB   C  N R 319 
THR OG1  O  N N 320 
THR CG2  C  N N 321 
THR OXT  O  N N 322 
THR H    H  N N 323 
THR H2   H  N N 324 
THR HA   H  N N 325 
THR HB   H  N N 326 
THR HG1  H  N N 327 
THR HG21 H  N N 328 
THR HG22 H  N N 329 
THR HG23 H  N N 330 
THR HXT  H  N N 331 
TRP N    N  N N 332 
TRP CA   C  N S 333 
TRP C    C  N N 334 
TRP O    O  N N 335 
TRP CB   C  N N 336 
TRP CG   C  Y N 337 
TRP CD1  C  Y N 338 
TRP CD2  C  Y N 339 
TRP NE1  N  Y N 340 
TRP CE2  C  Y N 341 
TRP CE3  C  Y N 342 
TRP CZ2  C  Y N 343 
TRP CZ3  C  Y N 344 
TRP CH2  C  Y N 345 
TRP OXT  O  N N 346 
TRP H    H  N N 347 
TRP H2   H  N N 348 
TRP HA   H  N N 349 
TRP HB2  H  N N 350 
TRP HB3  H  N N 351 
TRP HD1  H  N N 352 
TRP HE1  H  N N 353 
TRP HE3  H  N N 354 
TRP HZ2  H  N N 355 
TRP HZ3  H  N N 356 
TRP HH2  H  N N 357 
TRP HXT  H  N N 358 
TYR N    N  N N 359 
TYR CA   C  N S 360 
TYR C    C  N N 361 
TYR O    O  N N 362 
TYR CB   C  N N 363 
TYR CG   C  Y N 364 
TYR CD1  C  Y N 365 
TYR CD2  C  Y N 366 
TYR CE1  C  Y N 367 
TYR CE2  C  Y N 368 
TYR CZ   C  Y N 369 
TYR OH   O  N N 370 
TYR OXT  O  N N 371 
TYR H    H  N N 372 
TYR H2   H  N N 373 
TYR HA   H  N N 374 
TYR HB2  H  N N 375 
TYR HB3  H  N N 376 
TYR HD1  H  N N 377 
TYR HD2  H  N N 378 
TYR HE1  H  N N 379 
TYR HE2  H  N N 380 
TYR HH   H  N N 381 
TYR HXT  H  N N 382 
VAL N    N  N N 383 
VAL CA   C  N S 384 
VAL C    C  N N 385 
VAL O    O  N N 386 
VAL CB   C  N N 387 
VAL CG1  C  N N 388 
VAL CG2  C  N N 389 
VAL OXT  O  N N 390 
VAL H    H  N N 391 
VAL H2   H  N N 392 
VAL HA   H  N N 393 
VAL HB   H  N N 394 
VAL HG11 H  N N 395 
VAL HG12 H  N N 396 
VAL HG13 H  N N 397 
VAL HG21 H  N N 398 
VAL HG22 H  N N 399 
VAL HG23 H  N N 400 
VAL HXT  H  N N 401 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
DMS S   O    doub N N 83  
DMS S   C1   sing N N 84  
DMS S   C2   sing N N 85  
DMS C1  H11  sing N N 86  
DMS C1  H12  sing N N 87  
DMS C1  H13  sing N N 88  
DMS C2  H21  sing N N 89  
DMS C2  H22  sing N N 90  
DMS C2  H23  sing N N 91  
GLN N   CA   sing N N 92  
GLN N   H    sing N N 93  
GLN N   H2   sing N N 94  
GLN CA  C    sing N N 95  
GLN CA  CB   sing N N 96  
GLN CA  HA   sing N N 97  
GLN C   O    doub N N 98  
GLN C   OXT  sing N N 99  
GLN CB  CG   sing N N 100 
GLN CB  HB2  sing N N 101 
GLN CB  HB3  sing N N 102 
GLN CG  CD   sing N N 103 
GLN CG  HG2  sing N N 104 
GLN CG  HG3  sing N N 105 
GLN CD  OE1  doub N N 106 
GLN CD  NE2  sing N N 107 
GLN NE2 HE21 sing N N 108 
GLN NE2 HE22 sing N N 109 
GLN OXT HXT  sing N N 110 
GLU N   CA   sing N N 111 
GLU N   H    sing N N 112 
GLU N   H2   sing N N 113 
GLU CA  C    sing N N 114 
GLU CA  CB   sing N N 115 
GLU CA  HA   sing N N 116 
GLU C   O    doub N N 117 
GLU C   OXT  sing N N 118 
GLU CB  CG   sing N N 119 
GLU CB  HB2  sing N N 120 
GLU CB  HB3  sing N N 121 
GLU CG  CD   sing N N 122 
GLU CG  HG2  sing N N 123 
GLU CG  HG3  sing N N 124 
GLU CD  OE1  doub N N 125 
GLU CD  OE2  sing N N 126 
GLU OE2 HE2  sing N N 127 
GLU OXT HXT  sing N N 128 
GLY N   CA   sing N N 129 
GLY N   H    sing N N 130 
GLY N   H2   sing N N 131 
GLY CA  C    sing N N 132 
GLY CA  HA2  sing N N 133 
GLY CA  HA3  sing N N 134 
GLY C   O    doub N N 135 
GLY C   OXT  sing N N 136 
GLY OXT HXT  sing N N 137 
HIS N   CA   sing N N 138 
HIS N   H    sing N N 139 
HIS N   H2   sing N N 140 
HIS CA  C    sing N N 141 
HIS CA  CB   sing N N 142 
HIS CA  HA   sing N N 143 
HIS C   O    doub N N 144 
HIS C   OXT  sing N N 145 
HIS CB  CG   sing N N 146 
HIS CB  HB2  sing N N 147 
HIS CB  HB3  sing N N 148 
HIS CG  ND1  sing Y N 149 
HIS CG  CD2  doub Y N 150 
HIS ND1 CE1  doub Y N 151 
HIS ND1 HD1  sing N N 152 
HIS CD2 NE2  sing Y N 153 
HIS CD2 HD2  sing N N 154 
HIS CE1 NE2  sing Y N 155 
HIS CE1 HE1  sing N N 156 
HIS NE2 HE2  sing N N 157 
HIS OXT HXT  sing N N 158 
HOH O   H1   sing N N 159 
HOH O   H2   sing N N 160 
ILE N   CA   sing N N 161 
ILE N   H    sing N N 162 
ILE N   H2   sing N N 163 
ILE CA  C    sing N N 164 
ILE CA  CB   sing N N 165 
ILE CA  HA   sing N N 166 
ILE C   O    doub N N 167 
ILE C   OXT  sing N N 168 
ILE CB  CG1  sing N N 169 
ILE CB  CG2  sing N N 170 
ILE CB  HB   sing N N 171 
ILE CG1 CD1  sing N N 172 
ILE CG1 HG12 sing N N 173 
ILE CG1 HG13 sing N N 174 
ILE CG2 HG21 sing N N 175 
ILE CG2 HG22 sing N N 176 
ILE CG2 HG23 sing N N 177 
ILE CD1 HD11 sing N N 178 
ILE CD1 HD12 sing N N 179 
ILE CD1 HD13 sing N N 180 
ILE OXT HXT  sing N N 181 
LEU N   CA   sing N N 182 
LEU N   H    sing N N 183 
LEU N   H2   sing N N 184 
LEU CA  C    sing N N 185 
LEU CA  CB   sing N N 186 
LEU CA  HA   sing N N 187 
LEU C   O    doub N N 188 
LEU C   OXT  sing N N 189 
LEU CB  CG   sing N N 190 
LEU CB  HB2  sing N N 191 
LEU CB  HB3  sing N N 192 
LEU CG  CD1  sing N N 193 
LEU CG  CD2  sing N N 194 
LEU CG  HG   sing N N 195 
LEU CD1 HD11 sing N N 196 
LEU CD1 HD12 sing N N 197 
LEU CD1 HD13 sing N N 198 
LEU CD2 HD21 sing N N 199 
LEU CD2 HD22 sing N N 200 
LEU CD2 HD23 sing N N 201 
LEU OXT HXT  sing N N 202 
LYS N   CA   sing N N 203 
LYS N   H    sing N N 204 
LYS N   H2   sing N N 205 
LYS CA  C    sing N N 206 
LYS CA  CB   sing N N 207 
LYS CA  HA   sing N N 208 
LYS C   O    doub N N 209 
LYS C   OXT  sing N N 210 
LYS CB  CG   sing N N 211 
LYS CB  HB2  sing N N 212 
LYS CB  HB3  sing N N 213 
LYS CG  CD   sing N N 214 
LYS CG  HG2  sing N N 215 
LYS CG  HG3  sing N N 216 
LYS CD  CE   sing N N 217 
LYS CD  HD2  sing N N 218 
LYS CD  HD3  sing N N 219 
LYS CE  NZ   sing N N 220 
LYS CE  HE2  sing N N 221 
LYS CE  HE3  sing N N 222 
LYS NZ  HZ1  sing N N 223 
LYS NZ  HZ2  sing N N 224 
LYS NZ  HZ3  sing N N 225 
LYS OXT HXT  sing N N 226 
MET N   CA   sing N N 227 
MET N   H    sing N N 228 
MET N   H2   sing N N 229 
MET CA  C    sing N N 230 
MET CA  CB   sing N N 231 
MET CA  HA   sing N N 232 
MET C   O    doub N N 233 
MET C   OXT  sing N N 234 
MET CB  CG   sing N N 235 
MET CB  HB2  sing N N 236 
MET CB  HB3  sing N N 237 
MET CG  SD   sing N N 238 
MET CG  HG2  sing N N 239 
MET CG  HG3  sing N N 240 
MET SD  CE   sing N N 241 
MET CE  HE1  sing N N 242 
MET CE  HE2  sing N N 243 
MET CE  HE3  sing N N 244 
MET OXT HXT  sing N N 245 
PHE N   CA   sing N N 246 
PHE N   H    sing N N 247 
PHE N   H2   sing N N 248 
PHE CA  C    sing N N 249 
PHE CA  CB   sing N N 250 
PHE CA  HA   sing N N 251 
PHE C   O    doub N N 252 
PHE C   OXT  sing N N 253 
PHE CB  CG   sing N N 254 
PHE CB  HB2  sing N N 255 
PHE CB  HB3  sing N N 256 
PHE CG  CD1  doub Y N 257 
PHE CG  CD2  sing Y N 258 
PHE CD1 CE1  sing Y N 259 
PHE CD1 HD1  sing N N 260 
PHE CD2 CE2  doub Y N 261 
PHE CD2 HD2  sing N N 262 
PHE CE1 CZ   doub Y N 263 
PHE CE1 HE1  sing N N 264 
PHE CE2 CZ   sing Y N 265 
PHE CE2 HE2  sing N N 266 
PHE CZ  HZ   sing N N 267 
PHE OXT HXT  sing N N 268 
PRO N   CA   sing N N 269 
PRO N   CD   sing N N 270 
PRO N   H    sing N N 271 
PRO CA  C    sing N N 272 
PRO CA  CB   sing N N 273 
PRO CA  HA   sing N N 274 
PRO C   O    doub N N 275 
PRO C   OXT  sing N N 276 
PRO CB  CG   sing N N 277 
PRO CB  HB2  sing N N 278 
PRO CB  HB3  sing N N 279 
PRO CG  CD   sing N N 280 
PRO CG  HG2  sing N N 281 
PRO CG  HG3  sing N N 282 
PRO CD  HD2  sing N N 283 
PRO CD  HD3  sing N N 284 
PRO OXT HXT  sing N N 285 
SER N   CA   sing N N 286 
SER N   H    sing N N 287 
SER N   H2   sing N N 288 
SER CA  C    sing N N 289 
SER CA  CB   sing N N 290 
SER CA  HA   sing N N 291 
SER C   O    doub N N 292 
SER C   OXT  sing N N 293 
SER CB  OG   sing N N 294 
SER CB  HB2  sing N N 295 
SER CB  HB3  sing N N 296 
SER OG  HG   sing N N 297 
SER OXT HXT  sing N N 298 
THR N   CA   sing N N 299 
THR N   H    sing N N 300 
THR N   H2   sing N N 301 
THR CA  C    sing N N 302 
THR CA  CB   sing N N 303 
THR CA  HA   sing N N 304 
THR C   O    doub N N 305 
THR C   OXT  sing N N 306 
THR CB  OG1  sing N N 307 
THR CB  CG2  sing N N 308 
THR CB  HB   sing N N 309 
THR OG1 HG1  sing N N 310 
THR CG2 HG21 sing N N 311 
THR CG2 HG22 sing N N 312 
THR CG2 HG23 sing N N 313 
THR OXT HXT  sing N N 314 
TRP N   CA   sing N N 315 
TRP N   H    sing N N 316 
TRP N   H2   sing N N 317 
TRP CA  C    sing N N 318 
TRP CA  CB   sing N N 319 
TRP CA  HA   sing N N 320 
TRP C   O    doub N N 321 
TRP C   OXT  sing N N 322 
TRP CB  CG   sing N N 323 
TRP CB  HB2  sing N N 324 
TRP CB  HB3  sing N N 325 
TRP CG  CD1  doub Y N 326 
TRP CG  CD2  sing Y N 327 
TRP CD1 NE1  sing Y N 328 
TRP CD1 HD1  sing N N 329 
TRP CD2 CE2  doub Y N 330 
TRP CD2 CE3  sing Y N 331 
TRP NE1 CE2  sing Y N 332 
TRP NE1 HE1  sing N N 333 
TRP CE2 CZ2  sing Y N 334 
TRP CE3 CZ3  doub Y N 335 
TRP CE3 HE3  sing N N 336 
TRP CZ2 CH2  doub Y N 337 
TRP CZ2 HZ2  sing N N 338 
TRP CZ3 CH2  sing Y N 339 
TRP CZ3 HZ3  sing N N 340 
TRP CH2 HH2  sing N N 341 
TRP OXT HXT  sing N N 342 
TYR N   CA   sing N N 343 
TYR N   H    sing N N 344 
TYR N   H2   sing N N 345 
TYR CA  C    sing N N 346 
TYR CA  CB   sing N N 347 
TYR CA  HA   sing N N 348 
TYR C   O    doub N N 349 
TYR C   OXT  sing N N 350 
TYR CB  CG   sing N N 351 
TYR CB  HB2  sing N N 352 
TYR CB  HB3  sing N N 353 
TYR CG  CD1  doub Y N 354 
TYR CG  CD2  sing Y N 355 
TYR CD1 CE1  sing Y N 356 
TYR CD1 HD1  sing N N 357 
TYR CD2 CE2  doub Y N 358 
TYR CD2 HD2  sing N N 359 
TYR CE1 CZ   doub Y N 360 
TYR CE1 HE1  sing N N 361 
TYR CE2 CZ   sing Y N 362 
TYR CE2 HE2  sing N N 363 
TYR CZ  OH   sing N N 364 
TYR OH  HH   sing N N 365 
TYR OXT HXT  sing N N 366 
VAL N   CA   sing N N 367 
VAL N   H    sing N N 368 
VAL N   H2   sing N N 369 
VAL CA  C    sing N N 370 
VAL CA  CB   sing N N 371 
VAL CA  HA   sing N N 372 
VAL C   O    doub N N 373 
VAL C   OXT  sing N N 374 
VAL CB  CG1  sing N N 375 
VAL CB  CG2  sing N N 376 
VAL CB  HB   sing N N 377 
VAL CG1 HG11 sing N N 378 
VAL CG1 HG12 sing N N 379 
VAL CG1 HG13 sing N N 380 
VAL CG2 HG21 sing N N 381 
VAL CG2 HG22 sing N N 382 
VAL CG2 HG23 sing N N 383 
VAL OXT HXT  sing N N 384 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      Other 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          'inhouse model' 
# 
_atom_sites.entry_id                    8RGU 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.020712 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.007456 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.006938 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
MN 
N  
O  
S  
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . ASN A 1 12  ? -19.604 0.950   43.338  1.00 31.39 ? 17  ASN A N   1 
ATOM   2    C  CA  . ASN A 1 12  ? -18.228 0.622   42.849  1.00 30.93 ? 17  ASN A CA  1 
ATOM   3    C  C   . ASN A 1 12  ? -17.201 1.591   43.415  1.00 29.96 ? 17  ASN A C   1 
ATOM   4    O  O   . ASN A 1 12  ? -17.356 2.822   43.338  1.00 30.14 ? 17  ASN A O   1 
ATOM   5    C  CB  . ASN A 1 12  ? -18.178 0.647   41.324  1.00 31.58 ? 17  ASN A CB  1 
ATOM   6    C  CG  . ASN A 1 12  ? -18.973 -0.490  40.695  1.00 33.52 ? 17  ASN A CG  1 
ATOM   7    O  OD1 . ASN A 1 12  ? -19.784 -0.265  39.795  1.00 35.38 ? 17  ASN A OD1 1 
ATOM   8    N  ND2 . ASN A 1 12  ? -18.757 -1.709  41.177  1.00 33.35 ? 17  ASN A ND2 1 
ATOM   9    N  N   . LEU A 1 13  ? -16.153 1.033   43.989  1.00 29.12 ? 18  LEU A N   1 
ATOM   10   C  CA  . LEU A 1 13  ? -15.175 1.831   44.708  1.00 27.99 ? 18  LEU A CA  1 
ATOM   11   C  C   . LEU A 1 13  ? -13.884 1.947   43.905  1.00 27.26 ? 18  LEU A C   1 
ATOM   12   O  O   . LEU A 1 13  ? -13.039 2.793   44.200  1.00 25.64 ? 18  LEU A O   1 
ATOM   13   C  CB  . LEU A 1 13  ? -14.918 1.181   46.075  1.00 28.40 ? 18  LEU A CB  1 
ATOM   14   C  CG  . LEU A 1 13  ? -15.920 1.457   47.216  1.00 29.78 ? 18  LEU A CG  1 
ATOM   15   C  CD1 . LEU A 1 13  ? -17.250 2.139   46.813  1.00 31.29 ? 18  LEU A CD1 1 
ATOM   16   C  CD2 . LEU A 1 13  ? -16.178 0.220   48.028  1.00 29.89 ? 18  LEU A CD2 1 
ATOM   17   N  N   . TYR A 1 14  ? -13.741 1.102   42.876  1.00 26.19 ? 19  TYR A N   1 
ATOM   18   C  CA  . TYR A 1 14  ? -12.437 0.891   42.260  1.00 25.63 ? 19  TYR A CA  1 
ATOM   19   C  C   . TYR A 1 14  ? -12.532 0.956   40.752  1.00 25.45 ? 19  TYR A C   1 
ATOM   20   O  O   . TYR A 1 14  ? -13.416 0.310   40.164  1.00 24.83 ? 19  TYR A O   1 
ATOM   21   C  CB  . TYR A 1 14  ? -11.855 -0.477  42.667  1.00 27.03 ? 19  TYR A CB  1 
ATOM   22   C  CG  . TYR A 1 14  ? -11.703 -0.667  44.154  1.00 27.10 ? 19  TYR A CG  1 
ATOM   23   C  CD1 . TYR A 1 14  ? -10.588 -0.184  44.816  1.00 29.76 ? 19  TYR A CD1 1 
ATOM   24   C  CD2 . TYR A 1 14  ? -12.673 -1.333  44.890  1.00 30.31 ? 19  TYR A CD2 1 
ATOM   25   C  CE1 . TYR A 1 14  ? -10.437 -0.332  46.201  1.00 29.57 ? 19  TYR A CE1 1 
ATOM   26   C  CE2 . TYR A 1 14  ? -12.539 -1.499  46.285  1.00 31.72 ? 19  TYR A CE2 1 
ATOM   27   C  CZ  . TYR A 1 14  ? -11.403 -0.995  46.923  1.00 30.66 ? 19  TYR A CZ  1 
ATOM   28   O  OH  . TYR A 1 14  ? -11.260 -1.146  48.286  1.00 33.00 ? 19  TYR A OH  1 
ATOM   29   N  N   . PHE A 1 15  ? -11.603 1.697   40.147  1.00 23.92 ? 20  PHE A N   1 
ATOM   30   C  CA  . PHE A 1 15  ? -11.583 1.946   38.677  1.00 24.33 ? 20  PHE A CA  1 
ATOM   31   C  C   . PHE A 1 15  ? -10.186 1.858   38.105  1.00 24.81 ? 20  PHE A C   1 
ATOM   32   O  O   . PHE A 1 15  ? -9.217  2.117   38.807  1.00 24.09 ? 20  PHE A O   1 
ATOM   33   C  CB  . PHE A 1 15  ? -12.226 3.310   38.360  1.00 23.92 ? 20  PHE A CB  1 
ATOM   34   C  CG  . PHE A 1 15  ? -13.582 3.482   38.983  1.00 22.31 ? 20  PHE A CG  1 
ATOM   35   C  CD1 . PHE A 1 15  ? -14.739 3.210   38.267  1.00 22.81 ? 20  PHE A CD1 1 
ATOM   36   C  CD2 . PHE A 1 15  ? -13.701 3.868   40.314  1.00 22.54 ? 20  PHE A CD2 1 
ATOM   37   C  CE1 . PHE A 1 15  ? -16.006 3.352   38.863  1.00 19.05 ? 20  PHE A CE1 1 
ATOM   38   C  CE2 . PHE A 1 15  ? -14.926 3.984   40.921  1.00 19.89 ? 20  PHE A CE2 1 
ATOM   39   C  CZ  . PHE A 1 15  ? -16.104 3.749   40.191  1.00 20.59 ? 20  PHE A CZ  1 
ATOM   40   N  N   . GLN A 1 16  ? -10.070 1.458   36.824  1.00 26.05 ? 21  GLN A N   1 
ATOM   41   C  CA  . GLN A 1 16  ? -8.770  1.328   36.200  1.00 27.26 ? 21  GLN A CA  1 
ATOM   42   C  C   . GLN A 1 16  ? -8.123  2.679   36.059  1.00 26.93 ? 21  GLN A C   1 
ATOM   43   O  O   . GLN A 1 16  ? -6.918  2.776   36.100  1.00 27.35 ? 21  GLN A O   1 
ATOM   44   C  CB  . GLN A 1 16  ? -8.820  0.623   34.823  1.00 28.31 ? 21  GLN A CB  1 
ATOM   45   C  CG  . GLN A 1 16  ? -8.573  -0.894  34.879  1.00 33.37 ? 21  GLN A CG  1 
ATOM   46   C  CD  . GLN A 1 16  ? -7.204  -1.301  35.441  1.00 38.55 ? 21  GLN A CD  1 
ATOM   47   O  OE1 . GLN A 1 16  ? -6.173  -0.699  35.121  1.00 43.61 ? 21  GLN A OE1 1 
ATOM   48   N  NE2 . GLN A 1 16  ? -7.191  -2.350  36.266  1.00 40.74 ? 21  GLN A NE2 1 
ATOM   49   N  N   . SER A 1 17  ? -8.931  3.718   35.875  1.00 27.50 ? 22  SER A N   1 
ATOM   50   C  CA  . SER A 1 17  ? -8.418  5.072   35.874  1.00 27.73 ? 22  SER A CA  1 
ATOM   51   C  C   . SER A 1 17  ? -9.472  6.044   36.363  1.00 27.89 ? 22  SER A C   1 
ATOM   52   O  O   . SER A 1 17  ? -10.666 5.748   36.330  1.00 28.27 ? 22  SER A O   1 
ATOM   53   C  CB  . SER A 1 17  ? -7.838  5.478   34.495  1.00 28.19 ? 22  SER A CB  1 
ATOM   54   O  OG  . SER A 1 17  ? -8.829  5.455   33.490  1.00 29.21 ? 22  SER A OG  1 
ATOM   55   N  N   . VAL A 1 18  ? -9.014  7.191   36.868  1.00 27.77 ? 23  VAL A N   1 
ATOM   56   C  CA  . VAL A 1 18  ? -9.910  8.218   37.372  1.00 26.86 ? 23  VAL A CA  1 
ATOM   57   C  C   . VAL A 1 18  ? -9.622  9.510   36.605  1.00 26.87 ? 23  VAL A C   1 
ATOM   58   O  O   . VAL A 1 18  ? -8.509  10.052  36.673  1.00 26.47 ? 23  VAL A O   1 
ATOM   59   C  CB  . VAL A 1 18  ? -9.736  8.420   38.920  1.00 27.09 ? 23  VAL A CB  1 
ATOM   60   C  CG1 . VAL A 1 18  ? -10.524 9.652   39.435  1.00 26.47 ? 23  VAL A CG1 1 
ATOM   61   C  CG2 . VAL A 1 18  ? -10.139 7.163   39.668  1.00 26.46 ? 23  VAL A CG2 1 
ATOM   62   N  N   . HIS A 1 19  ? -10.623 9.993   35.869  1.00 25.96 ? 24  HIS A N   1 
ATOM   63   C  CA  . HIS A 1 19  ? -10.474 11.215  35.093  1.00 25.86 ? 24  HIS A CA  1 
ATOM   64   C  C   . HIS A 1 19  ? -11.237 12.360  35.736  1.00 25.18 ? 24  HIS A C   1 
ATOM   65   O  O   . HIS A 1 19  ? -12.324 12.171  36.300  1.00 24.92 ? 24  HIS A O   1 
ATOM   66   C  CB  . HIS A 1 19  ? -11.025 11.022  33.664  1.00 25.78 ? 24  HIS A CB  1 
ATOM   67   C  CG  . HIS A 1 19  ? -10.469 9.832   32.959  1.00 28.21 ? 24  HIS A CG  1 
ATOM   68   N  ND1 . HIS A 1 19  ? -9.213  9.820   32.394  1.00 30.01 ? 24  HIS A ND1 1 
ATOM   69   C  CD2 . HIS A 1 19  ? -10.986 8.598   32.755  1.00 29.77 ? 24  HIS A CD2 1 
ATOM   70   C  CE1 . HIS A 1 19  ? -8.982  8.635   31.863  1.00 31.06 ? 24  HIS A CE1 1 
ATOM   71   N  NE2 . HIS A 1 19  ? -10.044 7.878   32.063  1.00 33.41 ? 24  HIS A NE2 1 
ATOM   72   N  N   . SER A 1 20  ? -10.695 13.559  35.581  1.00 24.56 ? 25  SER A N   1 
ATOM   73   C  CA  . SER A 1 20  ? -11.379 14.775  35.968  1.00 23.97 ? 25  SER A CA  1 
ATOM   74   C  C   . SER A 1 20  ? -11.941 15.401  34.687  1.00 23.44 ? 25  SER A C   1 
ATOM   75   O  O   . SER A 1 20  ? -11.181 15.736  33.781  1.00 23.21 ? 25  SER A O   1 
ATOM   76   C  CB  . SER A 1 20  ? -10.389 15.721  36.662  1.00 24.39 ? 25  SER A CB  1 
ATOM   77   O  OG  . SER A 1 20  ? -10.171 15.293  38.004  1.00 23.52 ? 25  SER A OG  1 
ATOM   78   N  N   . VAL A 1 21  ? -13.267 15.509  34.621  1.00 22.82 ? 26  VAL A N   1 
ATOM   79   C  CA  . VAL A 1 21  ? -13.985 15.922  33.432  1.00 22.82 ? 26  VAL A CA  1 
ATOM   80   C  C   . VAL A 1 21  ? -14.908 17.095  33.737  1.00 23.32 ? 26  VAL A C   1 
ATOM   81   O  O   . VAL A 1 21  ? -15.728 17.024  34.660  1.00 23.45 ? 26  VAL A O   1 
ATOM   82   C  CB  . VAL A 1 21  ? -14.867 14.770  32.891  1.00 23.01 ? 26  VAL A CB  1 
ATOM   83   C  CG1 . VAL A 1 21  ? -15.581 15.181  31.579  1.00 22.09 ? 26  VAL A CG1 1 
ATOM   84   C  CG2 . VAL A 1 21  ? -14.039 13.513  32.673  1.00 21.08 ? 26  VAL A CG2 1 
ATOM   85   N  N   . ALA A 1 22  ? -14.749 18.169  32.967  1.00 22.99 ? 27  ALA A N   1 
ATOM   86   C  CA  . ALA A 1 22  ? -15.675 19.313  32.968  1.00 23.23 ? 27  ALA A CA  1 
ATOM   87   C  C   . ALA A 1 22  ? -16.684 19.131  31.835  1.00 23.25 ? 27  ALA A C   1 
ATOM   88   O  O   . ALA A 1 22  ? -16.345 18.630  30.750  1.00 23.32 ? 27  ALA A O   1 
ATOM   89   C  CB  . ALA A 1 22  ? -14.901 20.624  32.780  1.00 22.31 ? 27  ALA A CB  1 
ATOM   90   N  N   . VAL A 1 23  ? -17.924 19.513  32.083  1.00 23.17 ? 28  VAL A N   1 
ATOM   91   C  CA  . VAL A 1 23  ? -18.948 19.442  31.047  1.00 23.29 ? 28  VAL A CA  1 
ATOM   92   C  C   . VAL A 1 23  ? -19.531 20.846  30.845  1.00 24.04 ? 28  VAL A C   1 
ATOM   93   O  O   . VAL A 1 23  ? -19.896 21.532  31.818  1.00 22.77 ? 28  VAL A O   1 
ATOM   94   C  CB  . VAL A 1 23  ? -20.044 18.412  31.394  1.00 23.74 ? 28  VAL A CB  1 
ATOM   95   C  CG1 . VAL A 1 23  ? -21.164 18.463  30.386  1.00 22.67 ? 28  VAL A CG1 1 
ATOM   96   C  CG2 . VAL A 1 23  ? -19.451 16.978  31.431  1.00 22.67 ? 28  VAL A CG2 1 
ATOM   97   N  N   . ILE A 1 24  ? -19.553 21.280  29.589  1.00 23.46 ? 29  ILE A N   1 
ATOM   98   C  CA  . ILE A 1 24  ? -20.108 22.586  29.212  1.00 24.77 ? 29  ILE A CA  1 
ATOM   99   C  C   . ILE A 1 24  ? -21.165 22.309  28.146  1.00 25.14 ? 29  ILE A C   1 
ATOM   100  O  O   . ILE A 1 24  ? -20.878 21.627  27.156  1.00 23.01 ? 29  ILE A O   1 
ATOM   101  C  CB  . ILE A 1 24  ? -19.029 23.517  28.594  1.00 23.89 ? 29  ILE A CB  1 
ATOM   102  C  CG1 . ILE A 1 24  ? -17.817 23.685  29.525  1.00 25.83 ? 29  ILE A CG1 1 
ATOM   103  C  CG2 . ILE A 1 24  ? -19.647 24.907  28.204  1.00 26.77 ? 29  ILE A CG2 1 
ATOM   104  C  CD1 . ILE A 1 24  ? -16.597 24.237  28.810  1.00 26.05 ? 29  ILE A CD1 1 
ATOM   105  N  N   . GLY A 1 25  ? -22.382 22.817  28.348  1.00 26.06 ? 30  GLY A N   1 
ATOM   106  C  CA  . GLY A 1 25  ? -23.370 22.854  27.259  1.00 26.62 ? 30  GLY A CA  1 
ATOM   107  C  C   . GLY A 1 25  ? -23.195 24.121  26.427  1.00 28.17 ? 30  GLY A C   1 
ATOM   108  O  O   . GLY A 1 25  ? -23.063 25.237  26.976  1.00 27.95 ? 30  GLY A O   1 
ATOM   109  N  N   . ALA A 1 26  ? -23.160 23.961  25.099  1.00 28.10 ? 31  ALA A N   1 
ATOM   110  C  CA  . ALA A 1 26  ? -22.925 25.073  24.200  1.00 28.44 ? 31  ALA A CA  1 
ATOM   111  C  C   . ALA A 1 26  ? -23.937 24.964  23.074  1.00 29.51 ? 31  ALA A C   1 
ATOM   112  O  O   . ALA A 1 26  ? -23.630 24.413  22.009  1.00 28.91 ? 31  ALA A O   1 
ATOM   113  C  CB  . ALA A 1 26  ? -21.488 25.062  23.676  1.00 27.91 ? 31  ALA A CB  1 
ATOM   114  N  N   . PRO A 1 27  ? -25.165 25.470  23.319  1.00 30.62 ? 32  PRO A N   1 
ATOM   115  C  CA  . PRO A 1 27  ? -26.250 25.279  22.365  1.00 31.51 ? 32  PRO A CA  1 
ATOM   116  C  C   . PRO A 1 27  ? -26.230 26.220  21.139  1.00 31.88 ? 32  PRO A C   1 
ATOM   117  O  O   . PRO A 1 27  ? -27.254 26.817  20.828  1.00 32.66 ? 32  PRO A O   1 
ATOM   118  C  CB  . PRO A 1 27  ? -27.504 25.465  23.232  1.00 31.47 ? 32  PRO A CB  1 
ATOM   119  C  CG  . PRO A 1 27  ? -27.090 26.388  24.309  1.00 31.79 ? 32  PRO A CG  1 
ATOM   120  C  CD  . PRO A 1 27  ? -25.644 26.061  24.591  1.00 30.70 ? 32  PRO A CD  1 
ATOM   121  N  N   . PHE A 1 28  ? -25.082 26.339  20.464  1.00 32.29 ? 33  PHE A N   1 
ATOM   122  C  CA  . PHE A 1 28  ? -24.942 27.134  19.225  1.00 32.97 ? 33  PHE A CA  1 
ATOM   123  C  C   . PHE A 1 28  ? -25.884 26.562  18.175  1.00 32.77 ? 33  PHE A C   1 
ATOM   124  O  O   . PHE A 1 28  ? -25.902 25.353  17.944  1.00 32.24 ? 33  PHE A O   1 
ATOM   125  C  CB  . PHE A 1 28  ? -23.523 27.007  18.617  1.00 33.37 ? 33  PHE A CB  1 
ATOM   126  C  CG  . PHE A 1 28  ? -22.428 27.761  19.346  1.00 35.28 ? 33  PHE A CG  1 
ATOM   127  C  CD1 . PHE A 1 28  ? -22.280 27.681  20.730  1.00 36.56 ? 33  PHE A CD1 1 
ATOM   128  C  CD2 . PHE A 1 28  ? -21.499 28.511  18.617  1.00 37.04 ? 33  PHE A CD2 1 
ATOM   129  C  CE1 . PHE A 1 28  ? -21.245 28.377  21.397  1.00 37.09 ? 33  PHE A CE1 1 
ATOM   130  C  CE2 . PHE A 1 28  ? -20.454 29.199  19.271  1.00 38.17 ? 33  PHE A CE2 1 
ATOM   131  C  CZ  . PHE A 1 28  ? -20.331 29.122  20.664  1.00 36.88 ? 33  PHE A CZ  1 
ATOM   132  N  N   . SER A 1 29  ? -26.645 27.423  17.510  1.00 32.51 ? 34  SER A N   1 
ATOM   133  C  CA  . SER A 1 29  ? -27.354 26.988  16.314  1.00 31.99 ? 34  SER A CA  1 
ATOM   134  C  C   . SER A 1 29  ? -27.066 27.928  15.149  1.00 32.16 ? 34  SER A C   1 
ATOM   135  O  O   . SER A 1 29  ? -27.395 27.633  14.002  1.00 32.02 ? 34  SER A O   1 
ATOM   136  C  CB  . SER A 1 29  ? -28.858 26.825  16.571  1.00 31.77 ? 34  SER A CB  1 
ATOM   137  O  OG  . SER A 1 29  ? -29.449 28.078  16.805  1.00 32.63 ? 34  SER A OG  1 
ATOM   138  N  N   . GLN A 1 30  ? -26.407 29.044  15.437  1.00 32.40 ? 35  GLN A N   1 
ATOM   139  C  CA  . GLN A 1 30  ? -26.262 30.088  14.430  1.00 33.25 ? 35  GLN A CA  1 
ATOM   140  C  C   . GLN A 1 30  ? -25.129 29.849  13.434  1.00 32.49 ? 35  GLN A C   1 
ATOM   141  O  O   . GLN A 1 30  ? -24.953 30.639  12.507  1.00 32.11 ? 35  GLN A O   1 
ATOM   142  C  CB  . GLN A 1 30  ? -26.197 31.491  15.070  1.00 33.87 ? 35  GLN A CB  1 
ATOM   143  C  CG  . GLN A 1 30  ? -27.560 32.007  15.509  1.00 37.42 ? 35  GLN A CG  1 
ATOM   144  C  CD  . GLN A 1 30  ? -27.538 33.485  15.886  1.00 40.48 ? 35  GLN A CD  1 
ATOM   145  O  OE1 . GLN A 1 30  ? -26.906 33.880  16.856  1.00 42.90 ? 35  GLN A OE1 1 
ATOM   146  N  NE2 . GLN A 1 30  ? -28.241 34.295  15.124  1.00 42.31 ? 35  GLN A NE2 1 
ATOM   147  N  N   . GLY A 1 31  ? -24.365 28.765  13.623  1.00 31.95 ? 36  GLY A N   1 
ATOM   148  C  CA  . GLY A 1 31  ? -23.356 28.377  12.640  1.00 30.76 ? 36  GLY A CA  1 
ATOM   149  C  C   . GLY A 1 31  ? -23.973 27.613  11.485  1.00 30.62 ? 36  GLY A C   1 
ATOM   150  O  O   . GLY A 1 31  ? -23.251 27.163  10.596  1.00 29.92 ? 36  GLY A O   1 
ATOM   151  N  N   . GLN A 1 32  ? -25.306 27.453  11.512  1.00 30.83 ? 37  GLN A N   1 
ATOM   152  C  CA  . GLN A 1 32  ? -26.082 26.810  10.435  1.00 31.39 ? 37  GLN A CA  1 
ATOM   153  C  C   . GLN A 1 32  ? -27.559 27.260  10.464  1.00 32.88 ? 37  GLN A C   1 
ATOM   154  O  O   . GLN A 1 32  ? -27.935 28.133  11.266  1.00 33.10 ? 37  GLN A O   1 
ATOM   155  C  CB  . GLN A 1 32  ? -25.953 25.264  10.443  1.00 30.83 ? 37  GLN A CB  1 
ATOM   156  C  CG  . GLN A 1 32  ? -26.250 24.600  11.785  1.00 28.97 ? 37  GLN A CG  1 
ATOM   157  C  CD  . GLN A 1 32  ? -27.739 24.415  12.058  1.00 31.08 ? 37  GLN A CD  1 
ATOM   158  O  OE1 . GLN A 1 32  ? -28.405 23.583  11.431  1.00 30.44 ? 37  GLN A OE1 1 
ATOM   159  N  NE2 . GLN A 1 32  ? -28.273 25.199  12.997  1.00 30.04 ? 37  GLN A NE2 1 
ATOM   160  N  N   . LYS A 1 33  ? -28.390 26.671  9.601   1.00 33.89 ? 38  LYS A N   1 
ATOM   161  C  CA  . LYS A 1 33  ? -29.753 27.201  9.378   1.00 35.09 ? 38  LYS A CA  1 
ATOM   162  C  C   . LYS A 1 33  ? -30.897 26.346  9.907   1.00 35.61 ? 38  LYS A C   1 
ATOM   163  O  O   . LYS A 1 33  ? -32.048 26.789  9.897   1.00 35.84 ? 38  LYS A O   1 
ATOM   164  C  CB  . LYS A 1 33  ? -29.982 27.528  7.890   1.00 35.09 ? 38  LYS A CB  1 
ATOM   165  C  CG  . LYS A 1 33  ? -29.193 28.745  7.411   1.00 36.57 ? 38  LYS A CG  1 
ATOM   166  C  CD  . LYS A 1 33  ? -29.466 29.084  5.942   1.00 39.07 ? 38  LYS A CD  1 
ATOM   167  C  CE  . LYS A 1 33  ? -28.618 30.271  5.502   1.00 40.72 ? 38  LYS A CE  1 
ATOM   168  N  NZ  . LYS A 1 33  ? -27.209 29.889  5.137   1.00 42.53 ? 38  LYS A NZ  1 
ATOM   169  N  N   . ARG A 1 34  ? -30.613 25.132  10.372  1.00 35.53 ? 39  ARG A N   1 
ATOM   170  C  CA  . ARG A 1 34  ? -31.691 24.247  10.832  1.00 35.98 ? 39  ARG A CA  1 
ATOM   171  C  C   . ARG A 1 34  ? -31.927 24.430  12.331  1.00 35.98 ? 39  ARG A C   1 
ATOM   172  O  O   . ARG A 1 34  ? -30.978 24.423  13.141  1.00 35.91 ? 39  ARG A O   1 
ATOM   173  C  CB  . ARG A 1 34  ? -31.409 22.776  10.491  1.00 36.09 ? 39  ARG A CB  1 
ATOM   174  C  CG  . ARG A 1 34  ? -31.109 22.539  9.004   1.00 38.17 ? 39  ARG A CG  1 
ATOM   175  C  CD  . ARG A 1 34  ? -32.058 21.516  8.425   1.00 43.23 ? 39  ARG A CD  1 
ATOM   176  N  NE  . ARG A 1 34  ? -31.402 20.269  8.073   1.00 45.35 ? 39  ARG A NE  1 
ATOM   177  C  CZ  . ARG A 1 34  ? -32.045 19.173  7.680   1.00 47.42 ? 39  ARG A CZ  1 
ATOM   178  N  NH1 . ARG A 1 34  ? -33.373 19.164  7.611   1.00 47.09 ? 39  ARG A NH1 1 
ATOM   179  N  NH2 . ARG A 1 34  ? -31.360 18.072  7.378   1.00 47.23 ? 39  ARG A NH2 1 
ATOM   180  N  N   . LYS A 1 35  ? -33.189 24.625  12.701  1.00 35.43 ? 40  LYS A N   1 
ATOM   181  C  CA  . LYS A 1 35  ? -33.515 24.799  14.110  1.00 34.87 ? 40  LYS A CA  1 
ATOM   182  C  C   . LYS A 1 35  ? -33.486 23.444  14.806  1.00 33.09 ? 40  LYS A C   1 
ATOM   183  O  O   . LYS A 1 35  ? -33.768 22.414  14.181  1.00 33.03 ? 40  LYS A O   1 
ATOM   184  C  CB  . LYS A 1 35  ? -34.872 25.511  14.302  1.00 35.45 ? 40  LYS A CB  1 
ATOM   185  C  CG  . LYS A 1 35  ? -35.986 25.072  13.352  1.00 38.69 ? 40  LYS A CG  1 
ATOM   186  C  CD  . LYS A 1 35  ? -37.165 26.096  13.359  1.00 42.41 ? 40  LYS A CD  1 
ATOM   187  C  CE  . LYS A 1 35  ? -36.708 27.495  12.917  1.00 43.93 ? 40  LYS A CE  1 
ATOM   188  N  NZ  . LYS A 1 35  ? -37.722 28.555  13.192  1.00 46.05 ? 40  LYS A NZ  1 
ATOM   189  N  N   . GLY A 1 36  ? -33.118 23.443  16.084  1.00 31.01 ? 41  GLY A N   1 
ATOM   190  C  CA  . GLY A 1 36  ? -33.218 22.230  16.894  1.00 29.38 ? 41  GLY A CA  1 
ATOM   191  C  C   . GLY A 1 36  ? -31.901 21.754  17.503  1.00 28.17 ? 41  GLY A C   1 
ATOM   192  O  O   . GLY A 1 36  ? -31.902 21.106  18.542  1.00 27.79 ? 41  GLY A O   1 
ATOM   193  N  N   . VAL A 1 37  ? -30.791 22.070  16.847  1.00 27.01 ? 42  VAL A N   1 
ATOM   194  C  CA  . VAL A 1 37  ? -29.460 21.635  17.309  1.00 26.21 ? 42  VAL A CA  1 
ATOM   195  C  C   . VAL A 1 37  ? -29.058 22.314  18.637  1.00 26.51 ? 42  VAL A C   1 
ATOM   196  O  O   . VAL A 1 37  ? -28.238 21.789  19.387  1.00 25.85 ? 42  VAL A O   1 
ATOM   197  C  CB  . VAL A 1 37  ? -28.390 21.835  16.195  1.00 25.99 ? 42  VAL A CB  1 
ATOM   198  C  CG1 . VAL A 1 37  ? -28.074 23.323  15.979  1.00 25.36 ? 42  VAL A CG1 1 
ATOM   199  C  CG2 . VAL A 1 37  ? -27.121 21.021  16.480  1.00 24.13 ? 42  VAL A CG2 1 
ATOM   200  N  N   . GLU A 1 38  ? -29.639 23.485  18.925  1.00 26.59 ? 43  GLU A N   1 
ATOM   201  C  CA  . GLU A 1 38  ? -29.456 24.133  20.219  1.00 26.92 ? 43  GLU A CA  1 
ATOM   202  C  C   . GLU A 1 38  ? -29.983 23.241  21.364  1.00 26.21 ? 43  GLU A C   1 
ATOM   203  O  O   . GLU A 1 38  ? -29.599 23.429  22.509  1.00 27.65 ? 43  GLU A O   1 
ATOM   204  C  CB  . GLU A 1 38  ? -30.142 25.511  20.249  1.00 27.90 ? 43  GLU A CB  1 
ATOM   205  C  CG  . GLU A 1 38  ? -31.653 25.419  20.273  1.00 29.31 ? 43  GLU A CG  1 
ATOM   206  C  CD  . GLU A 1 38  ? -32.307 25.415  18.893  1.00 34.05 ? 43  GLU A CD  1 
ATOM   207  O  OE1 . GLU A 1 38  ? -31.671 25.023  17.877  1.00 32.69 ? 43  GLU A OE1 1 
ATOM   208  O  OE2 . GLU A 1 38  ? -33.495 25.805  18.830  1.00 35.38 ? 43  GLU A OE2 1 
ATOM   209  N  N   . HIS A 1 39  ? -30.855 22.285  21.045  1.00 25.61 ? 44  HIS A N   1 
ATOM   210  C  CA  . HIS A 1 39  ? -31.337 21.272  21.985  1.00 25.48 ? 44  HIS A CA  1 
ATOM   211  C  C   . HIS A 1 39  ? -30.453 20.029  22.117  1.00 24.80 ? 44  HIS A C   1 
ATOM   212  O  O   . HIS A 1 39  ? -30.794 19.100  22.849  1.00 24.20 ? 44  HIS A O   1 
ATOM   213  C  CB  . HIS A 1 39  ? -32.750 20.827  21.604  1.00 26.57 ? 44  HIS A CB  1 
ATOM   214  C  CG  . HIS A 1 39  ? -33.727 21.950  21.595  1.00 30.66 ? 44  HIS A CG  1 
ATOM   215  N  ND1 . HIS A 1 39  ? -33.828 22.846  22.639  1.00 33.41 ? 44  HIS A ND1 1 
ATOM   216  C  CD2 . HIS A 1 39  ? -34.630 22.343  20.666  1.00 34.11 ? 44  HIS A CD2 1 
ATOM   217  C  CE1 . HIS A 1 39  ? -34.758 23.742  22.355  1.00 34.92 ? 44  HIS A CE1 1 
ATOM   218  N  NE2 . HIS A 1 39  ? -35.264 23.455  21.167  1.00 34.94 ? 44  HIS A NE2 1 
ATOM   219  N  N   . GLY A 1 40  ? -29.339 20.002  21.390  1.00 24.01 ? 45  GLY A N   1 
ATOM   220  C  CA  . GLY A 1 40  ? -28.377 18.901  21.528  1.00 22.21 ? 45  GLY A CA  1 
ATOM   221  C  C   . GLY A 1 40  ? -27.923 18.677  22.972  1.00 20.82 ? 45  GLY A C   1 
ATOM   222  O  O   . GLY A 1 40  ? -27.936 17.543  23.451  1.00 18.92 ? 45  GLY A O   1 
ATOM   223  N  N   . PRO A 1 41  ? -27.489 19.749  23.667  1.00 20.72 ? 46  PRO A N   1 
ATOM   224  C  CA  . PRO A 1 41  ? -26.925 19.468  24.993  1.00 20.94 ? 46  PRO A CA  1 
ATOM   225  C  C   . PRO A 1 41  ? -27.935 18.873  25.973  1.00 21.28 ? 46  PRO A C   1 
ATOM   226  O  O   . PRO A 1 41  ? -27.580 17.983  26.756  1.00 20.77 ? 46  PRO A O   1 
ATOM   227  C  CB  . PRO A 1 41  ? -26.409 20.836  25.448  1.00 20.73 ? 46  PRO A CB  1 
ATOM   228  C  CG  . PRO A 1 41  ? -26.061 21.525  24.098  1.00 21.46 ? 46  PRO A CG  1 
ATOM   229  C  CD  . PRO A 1 41  ? -27.181 21.129  23.223  1.00 20.68 ? 46  PRO A CD  1 
ATOM   230  N  N   . ALA A 1 42  ? -29.181 19.346  25.919  1.00 21.31 ? 47  ALA A N   1 
ATOM   231  C  CA  . ALA A 1 42  ? -30.264 18.804  26.748  1.00 22.21 ? 47  ALA A CA  1 
ATOM   232  C  C   . ALA A 1 42  ? -30.522 17.355  26.392  1.00 22.10 ? 47  ALA A C   1 
ATOM   233  O  O   . ALA A 1 42  ? -30.715 16.528  27.278  1.00 23.13 ? 47  ALA A O   1 
ATOM   234  C  CB  . ALA A 1 42  ? -31.584 19.630  26.553  1.00 21.79 ? 47  ALA A CB  1 
ATOM   235  N  N   . ALA A 1 43  ? -30.578 17.055  25.088  1.00 21.73 ? 48  ALA A N   1 
ATOM   236  C  CA  . ALA A 1 43  ? -30.776 15.674  24.644  1.00 22.11 ? 48  ALA A CA  1 
ATOM   237  C  C   . ALA A 1 43  ? -29.683 14.741  25.205  1.00 21.57 ? 48  ALA A C   1 
ATOM   238  O  O   . ALA A 1 43  ? -29.963 13.645  25.667  1.00 22.59 ? 48  ALA A O   1 
ATOM   239  C  CB  . ALA A 1 43  ? -30.832 15.604  23.126  1.00 20.68 ? 48  ALA A CB  1 
ATOM   240  N  N   . ILE A 1 44  ? -28.436 15.181  25.157  1.00 22.20 ? 49  ILE A N   1 
ATOM   241  C  CA  . ILE A 1 44  ? -27.315 14.343  25.620  1.00 21.54 ? 49  ILE A CA  1 
ATOM   242  C  C   . ILE A 1 44  ? -27.314 14.175  27.164  1.00 22.82 ? 49  ILE A C   1 
ATOM   243  O  O   . ILE A 1 44  ? -27.074 13.059  27.685  1.00 21.87 ? 49  ILE A O   1 
ATOM   244  C  CB  . ILE A 1 44  ? -25.990 14.886  25.087  1.00 21.32 ? 49  ILE A CB  1 
ATOM   245  C  CG1 . ILE A 1 44  ? -25.997 14.849  23.545  1.00 18.82 ? 49  ILE A CG1 1 
ATOM   246  C  CG2 . ILE A 1 44  ? -24.774 14.109  25.691  1.00 21.01 ? 49  ILE A CG2 1 
ATOM   247  C  CD1 . ILE A 1 44  ? -24.842 15.671  22.876  1.00 17.88 ? 49  ILE A CD1 1 
ATOM   248  N  N   . ARG A 1 45  ? -27.643 15.256  27.879  1.00 22.80 ? 50  ARG A N   1 
ATOM   249  C  CA  . ARG A 1 45  ? -27.806 15.176  29.333  1.00 24.56 ? 50  ARG A CA  1 
ATOM   250  C  C   . ARG A 1 45  ? -28.971 14.260  29.707  1.00 25.30 ? 50  ARG A C   1 
ATOM   251  O  O   . ARG A 1 45  ? -28.871 13.488  30.660  1.00 25.12 ? 50  ARG A O   1 
ATOM   252  C  CB  . ARG A 1 45  ? -28.065 16.544  29.933  1.00 24.63 ? 50  ARG A CB  1 
ATOM   253  C  CG  . ARG A 1 45  ? -26.923 17.519  29.846  1.00 25.03 ? 50  ARG A CG  1 
ATOM   254  C  CD  . ARG A 1 45  ? -27.300 18.791  30.584  1.00 25.78 ? 50  ARG A CD  1 
ATOM   255  N  NE  . ARG A 1 45  ? -26.240 19.778  30.504  1.00 25.23 ? 50  ARG A NE  1 
ATOM   256  C  CZ  . ARG A 1 45  ? -25.248 19.865  31.373  1.00 26.21 ? 50  ARG A CZ  1 
ATOM   257  N  NH1 . ARG A 1 45  ? -25.186 19.011  32.385  1.00 24.35 ? 50  ARG A NH1 1 
ATOM   258  N  NH2 . ARG A 1 45  ? -24.315 20.812  31.217  1.00 28.44 ? 50  ARG A NH2 1 
ATOM   259  N  N   . GLU A 1 46  ? -30.080 14.356  28.968  1.00 26.47 ? 51  GLU A N   1 
ATOM   260  C  CA  . GLU A 1 46  ? -31.247 13.490  29.243  1.00 26.86 ? 51  GLU A CA  1 
ATOM   261  C  C   . GLU A 1 46  ? -31.008 12.011  28.947  1.00 26.79 ? 51  GLU A C   1 
ATOM   262  O  O   . GLU A 1 46  ? -31.638 11.146  29.550  1.00 26.78 ? 51  GLU A O   1 
ATOM   263  C  CB  . GLU A 1 46  ? -32.483 14.001  28.507  1.00 27.79 ? 51  GLU A CB  1 
ATOM   264  C  CG  . GLU A 1 46  ? -33.100 15.220  29.230  1.00 31.60 ? 51  GLU A CG  1 
ATOM   265  C  CD  . GLU A 1 46  ? -33.829 16.172  28.297  1.00 36.77 ? 51  GLU A CD  1 
ATOM   266  O  OE1 . GLU A 1 46  ? -34.389 15.712  27.273  1.00 39.38 ? 51  GLU A OE1 1 
ATOM   267  O  OE2 . GLU A 1 46  ? -33.846 17.390  28.603  1.00 39.75 ? 51  GLU A OE2 1 
ATOM   268  N  N   . ALA A 1 47  ? -30.090 11.724  28.026  1.00 25.22 ? 52  ALA A N   1 
ATOM   269  C  CA  . ALA A 1 47  ? -29.646 10.358  27.772  1.00 24.79 ? 52  ALA A CA  1 
ATOM   270  C  C   . ALA A 1 47  ? -28.773 9.805   28.916  1.00 24.20 ? 52  ALA A C   1 
ATOM   271  O  O   . ALA A 1 47  ? -28.310 8.664   28.857  1.00 23.68 ? 52  ALA A O   1 
ATOM   272  C  CB  . ALA A 1 47  ? -28.922 10.279  26.416  1.00 24.33 ? 52  ALA A CB  1 
ATOM   273  N  N   . GLY A 1 48  ? -28.567 10.622  29.954  1.00 23.72 ? 53  GLY A N   1 
ATOM   274  C  CA  . GLY A 1 48  ? -27.899 10.189  31.192  1.00 23.70 ? 53  GLY A CA  1 
ATOM   275  C  C   . GLY A 1 48  ? -26.379 10.327  31.239  1.00 23.20 ? 53  GLY A C   1 
ATOM   276  O  O   . GLY A 1 48  ? -25.711 9.542   31.922  1.00 23.55 ? 53  GLY A O   1 
ATOM   277  N  N   . LEU A 1 49  ? -25.840 11.322  30.534  1.00 23.12 ? 54  LEU A N   1 
ATOM   278  C  CA  . LEU A 1 49  ? -24.375 11.543  30.450  1.00 22.85 ? 54  LEU A CA  1 
ATOM   279  C  C   . LEU A 1 49  ? -23.675 11.637  31.814  1.00 22.95 ? 54  LEU A C   1 
ATOM   280  O  O   . LEU A 1 49  ? -22.676 10.959  32.044  1.00 22.65 ? 54  LEU A O   1 
ATOM   281  C  CB  . LEU A 1 49  ? -24.035 12.805  29.628  1.00 22.26 ? 54  LEU A CB  1 
ATOM   282  C  CG  . LEU A 1 49  ? -22.526 13.164  29.617  1.00 23.94 ? 54  LEU A CG  1 
ATOM   283  C  CD1 . LEU A 1 49  ? -21.765 12.102  28.799  1.00 23.99 ? 54  LEU A CD1 1 
ATOM   284  C  CD2 . LEU A 1 49  ? -22.208 14.545  29.087  1.00 24.69 ? 54  LEU A CD2 1 
ATOM   285  N  N   . MET A 1 50  ? -24.184 12.487  32.711  1.00 23.31 ? 55  MET A N   1 
ATOM   286  C  CA  . MET A 1 50  ? -23.504 12.705  34.003  1.00 24.41 ? 55  MET A CA  1 
ATOM   287  C  C   . MET A 1 50  ? -23.418 11.442  34.847  1.00 24.48 ? 55  MET A C   1 
ATOM   288  O  O   . MET A 1 50  ? -22.336 11.102  35.351  1.00 24.84 ? 55  MET A O   1 
ATOM   289  C  CB  . MET A 1 50  ? -24.107 13.887  34.781  1.00 24.21 ? 55  MET A CB  1 
ATOM   290  C  CG  . MET A 1 50  ? -24.103 15.206  33.989  1.00 27.04 ? 55  MET A CG  1 
ATOM   291  S  SD  . MET A 1 50  ? -22.494 15.683  33.253  1.00 28.26 ? 55  MET A SD  1 
ATOM   292  C  CE  . MET A 1 50  ? -21.604 16.176  34.725  1.00 29.39 ? 55  MET A CE  1 
ATOM   293  N  N   . LYS A 1 51  ? -24.537 10.726  34.917  1.00 24.91 ? 56  LYS A N   1 
ATOM   294  C  CA  . LYS A 1 51  ? -24.661 9.429   35.574  1.00 25.74 ? 56  LYS A CA  1 
ATOM   295  C  C   . LYS A 1 51  ? -23.652 8.440   34.994  1.00 25.41 ? 56  LYS A C   1 
ATOM   296  O  O   . LYS A 1 51  ? -22.968 7.727   35.739  1.00 24.10 ? 56  LYS A O   1 
ATOM   297  C  CB  . LYS A 1 51  ? -26.094 8.892   35.366  1.00 27.11 ? 56  LYS A CB  1 
ATOM   298  C  CG  . LYS A 1 51  ? -26.500 7.682   36.200  1.00 30.70 ? 56  LYS A CG  1 
ATOM   299  C  CD  . LYS A 1 51  ? -26.708 8.035   37.678  1.00 37.40 ? 56  LYS A CD  1 
ATOM   300  C  CE  . LYS A 1 51  ? -27.977 8.883   37.915  1.00 40.61 ? 56  LYS A CE  1 
ATOM   301  N  NZ  . LYS A 1 51  ? -28.256 9.049   39.388  1.00 42.70 ? 56  LYS A NZ  1 
ATOM   302  N  N   . ARG A 1 52  ? -23.550 8.407   33.662  1.00 24.17 ? 57  ARG A N   1 
ATOM   303  C  CA  . ARG A 1 52  ? -22.669 7.453   33.013  1.00 23.35 ? 57  ARG A CA  1 
ATOM   304  C  C   . ARG A 1 52  ? -21.226 7.735   33.402  1.00 23.03 ? 57  ARG A C   1 
ATOM   305  O  O   . ARG A 1 52  ? -20.511 6.815   33.781  1.00 22.54 ? 57  ARG A O   1 
ATOM   306  C  CB  . ARG A 1 52  ? -22.828 7.457   31.478  1.00 24.41 ? 57  ARG A CB  1 
ATOM   307  C  CG  . ARG A 1 52  ? -21.892 6.464   30.752  1.00 23.23 ? 57  ARG A CG  1 
ATOM   308  C  CD  . ARG A 1 52  ? -22.424 4.997   30.807  1.00 26.49 ? 57  ARG A CD  1 
ATOM   309  N  NE  . ARG A 1 52  ? -23.726 4.928   30.164  1.00 27.42 ? 57  ARG A NE  1 
ATOM   310  C  CZ  . ARG A 1 52  ? -23.906 4.823   28.846  1.00 27.81 ? 57  ARG A CZ  1 
ATOM   311  N  NH1 . ARG A 1 52  ? -25.132 4.810   28.345  1.00 26.84 ? 57  ARG A NH1 1 
ATOM   312  N  NH2 . ARG A 1 52  ? -22.866 4.733   28.028  1.00 24.59 ? 57  ARG A NH2 1 
ATOM   313  N  N   . LEU A 1 53  ? -20.828 9.004   33.333  1.00 22.27 ? 58  LEU A N   1 
ATOM   314  C  CA  . LEU A 1 53  ? -19.462 9.430   33.670  1.00 21.69 ? 58  LEU A CA  1 
ATOM   315  C  C   . LEU A 1 53  ? -19.134 9.145   35.137  1.00 22.12 ? 58  LEU A C   1 
ATOM   316  O  O   . LEU A 1 53  ? -18.033 8.709   35.448  1.00 21.71 ? 58  LEU A O   1 
ATOM   317  C  CB  . LEU A 1 53  ? -19.238 10.904  33.323  1.00 20.97 ? 58  LEU A CB  1 
ATOM   318  C  CG  . LEU A 1 53  ? -19.350 11.271  31.823  1.00 22.06 ? 58  LEU A CG  1 
ATOM   319  C  CD1 . LEU A 1 53  ? -19.134 12.737  31.609  1.00 20.29 ? 58  LEU A CD1 1 
ATOM   320  C  CD2 . LEU A 1 53  ? -18.376 10.463  30.981  1.00 21.29 ? 58  LEU A CD2 1 
ATOM   321  N  N   . SER A 1 54  ? -20.120 9.335   36.014  1.00 23.51 ? 59  SER A N   1 
ATOM   322  C  CA  . SER A 1 54  ? -19.961 9.030   37.451  1.00 24.86 ? 59  SER A CA  1 
ATOM   323  C  C   . SER A 1 54  ? -19.710 7.556   37.660  1.00 24.43 ? 59  SER A C   1 
ATOM   324  O  O   . SER A 1 54  ? -18.812 7.171   38.423  1.00 24.83 ? 59  SER A O   1 
ATOM   325  C  CB  . SER A 1 54  ? -21.181 9.500   38.251  1.00 25.43 ? 59  SER A CB  1 
ATOM   326  O  OG  . SER A 1 54  ? -21.095 10.907  38.398  1.00 28.57 ? 59  SER A OG  1 
ATOM   327  N  N   . SER A 1 55  ? -20.433 6.737   36.895  1.00 24.30 ? 60  SER A N   1 
ATOM   328  C  CA  . SER A 1 55  ? -20.299 5.280   36.955  1.00 23.91 ? 60  SER A CA  1 
ATOM   329  C  C   . SER A 1 55  ? -18.930 4.800   36.461  1.00 23.15 ? 60  SER A C   1 
ATOM   330  O  O   . SER A 1 55  ? -18.489 3.679   36.769  1.00 23.19 ? 60  SER A O   1 
ATOM   331  C  CB  . SER A 1 55  ? -21.473 4.601   36.219  1.00 24.43 ? 60  SER A CB  1 
ATOM   332  O  OG  . SER A 1 55  ? -21.262 4.627   34.823  1.00 25.35 ? 60  SER A OG  1 
ATOM   333  N  N   . LEU A 1 56  ? -18.243 5.662   35.722  1.00 22.53 ? 61  LEU A N   1 
ATOM   334  C  CA  . LEU A 1 56  ? -16.868 5.386   35.283  1.00 22.29 ? 61  LEU A CA  1 
ATOM   335  C  C   . LEU A 1 56  ? -15.821 5.976   36.204  1.00 22.62 ? 61  LEU A C   1 
ATOM   336  O  O   . LEU A 1 56  ? -14.637 5.917   35.896  1.00 21.98 ? 61  LEU A O   1 
ATOM   337  C  CB  . LEU A 1 56  ? -16.628 5.892   33.862  1.00 22.30 ? 61  LEU A CB  1 
ATOM   338  C  CG  . LEU A 1 56  ? -17.505 5.219   32.798  1.00 23.02 ? 61  LEU A CG  1 
ATOM   339  C  CD1 . LEU A 1 56  ? -17.350 5.999   31.467  1.00 22.40 ? 61  LEU A CD1 1 
ATOM   340  C  CD2 . LEU A 1 56  ? -17.153 3.762   32.640  1.00 21.63 ? 61  LEU A CD2 1 
ATOM   341  N  N   . GLY A 1 57  ? -16.263 6.541   37.331  1.00 23.07 ? 62  GLY A N   1 
ATOM   342  C  CA  . GLY A 1 57  ? -15.331 6.993   38.365  1.00 23.97 ? 62  GLY A CA  1 
ATOM   343  C  C   . GLY A 1 57  ? -14.731 8.362   38.088  1.00 23.83 ? 62  GLY A C   1 
ATOM   344  O  O   . GLY A 1 57  ? -13.683 8.706   38.645  1.00 23.72 ? 62  GLY A O   1 
ATOM   345  N  N   . CYS A 1 58  ? -15.384 9.146   37.232  1.00 23.18 ? 63  CYS A N   1 
ATOM   346  C  CA  . CYS A 1 58  ? -14.890 10.489  36.931  1.00 22.92 ? 63  CYS A CA  1 
ATOM   347  C  C   . CYS A 1 58  ? -15.188 11.455  38.072  1.00 23.46 ? 63  CYS A C   1 
ATOM   348  O  O   . CYS A 1 58  ? -16.265 11.399  38.653  1.00 23.59 ? 63  CYS A O   1 
ATOM   349  C  CB  . CYS A 1 58  ? -15.502 11.045  35.645  1.00 22.18 ? 63  CYS A CB  1 
ATOM   350  S  SG  . CYS A 1 58  ? -15.088 10.042  34.163  1.00 19.81 ? 63  CYS A SG  1 
ATOM   351  N  N   . HIS A 1 59  ? -14.241 12.329  38.381  1.00 23.54 ? 64  HIS A N   1 
ATOM   352  C  CA  . HIS A 1 59  ? -14.570 13.576  39.111  1.00 24.77 ? 64  HIS A CA  1 
ATOM   353  C  C   . HIS A 1 59  ? -15.217 14.524  38.112  1.00 24.81 ? 64  HIS A C   1 
ATOM   354  O  O   . HIS A 1 59  ? -14.676 14.740  37.040  1.00 24.04 ? 64  HIS A O   1 
ATOM   355  C  CB  . HIS A 1 59  ? -13.297 14.228  39.648  1.00 25.10 ? 64  HIS A CB  1 
ATOM   356  C  CG  . HIS A 1 59  ? -12.561 13.390  40.636  1.00 25.18 ? 64  HIS A CG  1 
ATOM   357  N  ND1 . HIS A 1 59  ? -13.127 12.956  41.814  1.00 27.19 ? 64  HIS A ND1 1 
ATOM   358  C  CD2 . HIS A 1 59  ? -11.282 12.951  40.649  1.00 27.53 ? 64  HIS A CD2 1 
ATOM   359  C  CE1 . HIS A 1 59  ? -12.239 12.255  42.497  1.00 26.30 ? 64  HIS A CE1 1 
ATOM   360  N  NE2 . HIS A 1 59  ? -11.111 12.236  41.811  1.00 26.36 ? 64  HIS A NE2 1 
ATOM   361  N  N   . LEU A 1 60  ? -16.380 15.064  38.447  1.00 25.83 ? 65  LEU A N   1 
ATOM   362  C  CA  . LEU A 1 60  ? -17.159 15.857  37.506  1.00 27.17 ? 65  LEU A CA  1 
ATOM   363  C  C   . LEU A 1 60  ? -17.312 17.299  37.967  1.00 28.35 ? 65  LEU A C   1 
ATOM   364  O  O   . LEU A 1 60  ? -17.610 17.545  39.146  1.00 28.25 ? 65  LEU A O   1 
ATOM   365  C  CB  . LEU A 1 60  ? -18.554 15.276  37.367  1.00 27.44 ? 65  LEU A CB  1 
ATOM   366  C  CG  . LEU A 1 60  ? -18.947 14.213  36.338  1.00 29.43 ? 65  LEU A CG  1 
ATOM   367  C  CD1 . LEU A 1 60  ? -17.924 14.080  35.184  1.00 29.62 ? 65  LEU A CD1 1 
ATOM   368  C  CD2 . LEU A 1 60  ? -19.236 12.905  37.009  1.00 30.42 ? 65  LEU A CD2 1 
ATOM   369  N  N   . LYS A 1 61  ? -17.099 18.243  37.050  1.00 28.26 ? 66  LYS A N   1 
ATOM   370  C  CA  . LYS A 1 61  ? -17.508 19.627  37.260  1.00 28.70 ? 66  LYS A CA  1 
ATOM   371  C  C   . LYS A 1 61  ? -18.438 19.998  36.116  1.00 29.35 ? 66  LYS A C   1 
ATOM   372  O  O   . LYS A 1 61  ? -18.045 19.984  34.938  1.00 29.09 ? 66  LYS A O   1 
ATOM   373  C  CB  . LYS A 1 61  ? -16.318 20.592  37.354  1.00 28.23 ? 66  LYS A CB  1 
ATOM   374  C  CG  . LYS A 1 61  ? -16.735 22.022  37.752  1.00 29.81 ? 66  LYS A CG  1 
ATOM   375  C  CD  . LYS A 1 61  ? -15.542 22.947  38.030  1.00 31.82 ? 66  LYS A CD  1 
ATOM   376  C  CE  . LYS A 1 61  ? -16.040 24.357  38.374  1.00 33.60 ? 66  LYS A CE  1 
ATOM   377  N  NZ  . LYS A 1 61  ? -14.946 25.383  38.400  1.00 33.94 ? 66  LYS A NZ  1 
ATOM   378  N  N   . ASP A 1 62  ? -19.685 20.301  36.460  1.00 29.87 ? 67  ASP A N   1 
ATOM   379  C  CA  . ASP A 1 62  ? -20.672 20.685  35.473  1.00 30.09 ? 67  ASP A CA  1 
ATOM   380  C  C   . ASP A 1 62  ? -20.780 22.223  35.425  1.00 31.27 ? 67  ASP A C   1 
ATOM   381  O  O   . ASP A 1 62  ? -21.239 22.855  36.400  1.00 30.85 ? 67  ASP A O   1 
ATOM   382  C  CB  . ASP A 1 62  ? -22.003 20.052  35.852  1.00 30.38 ? 67  ASP A CB  1 
ATOM   383  C  CG  . ASP A 1 62  ? -23.021 20.136  34.757  1.00 29.57 ? 67  ASP A CG  1 
ATOM   384  O  OD1 . ASP A 1 62  ? -22.855 20.926  33.805  1.00 30.00 ? 67  ASP A OD1 1 
ATOM   385  O  OD2 . ASP A 1 62  ? -24.008 19.398  34.863  1.00 32.14 ? 67  ASP A OD2 1 
ATOM   386  N  N   . PHE A 1 63  ? -20.323 22.817  34.318  1.00 31.21 ? 68  PHE A N   1 
ATOM   387  C  CA  . PHE A 1 63  ? -20.410 24.261  34.098  1.00 31.85 ? 68  PHE A CA  1 
ATOM   388  C  C   . PHE A 1 63  ? -21.798 24.715  33.660  1.00 32.72 ? 68  PHE A C   1 
ATOM   389  O  O   . PHE A 1 63  ? -22.022 25.913  33.478  1.00 32.86 ? 68  PHE A O   1 
ATOM   390  C  CB  . PHE A 1 63  ? -19.364 24.734  33.088  1.00 31.89 ? 68  PHE A CB  1 
ATOM   391  C  CG  . PHE A 1 63  ? -17.962 24.759  33.631  1.00 31.59 ? 68  PHE A CG  1 
ATOM   392  C  CD1 . PHE A 1 63  ? -17.249 23.586  33.802  1.00 31.42 ? 68  PHE A CD1 1 
ATOM   393  C  CD2 . PHE A 1 63  ? -17.364 25.965  33.984  1.00 32.46 ? 68  PHE A CD2 1 
ATOM   394  C  CE1 . PHE A 1 63  ? -15.936 23.597  34.326  1.00 32.15 ? 68  PHE A CE1 1 
ATOM   395  C  CE2 . PHE A 1 63  ? -16.057 26.004  34.495  1.00 33.70 ? 68  PHE A CE2 1 
ATOM   396  C  CZ  . PHE A 1 63  ? -15.334 24.804  34.663  1.00 33.83 ? 68  PHE A CZ  1 
ATOM   397  N  N   . GLY A 1 64  ? -22.719 23.761  33.517  1.00 33.60 ? 69  GLY A N   1 
ATOM   398  C  CA  . GLY A 1 64  ? -24.081 24.033  33.070  1.00 34.83 ? 69  GLY A CA  1 
ATOM   399  C  C   . GLY A 1 64  ? -24.105 24.372  31.588  1.00 36.62 ? 69  GLY A C   1 
ATOM   400  O  O   . GLY A 1 64  ? -23.133 24.121  30.848  1.00 35.93 ? 69  GLY A O   1 
ATOM   401  N  N   . ASP A 1 65  ? -25.216 24.941  31.146  1.00 37.49 ? 70  ASP A N   1 
ATOM   402  C  CA  . ASP A 1 65  ? -25.367 25.285  29.745  1.00 39.43 ? 70  ASP A CA  1 
ATOM   403  C  C   . ASP A 1 65  ? -25.259 26.778  29.593  1.00 40.31 ? 70  ASP A C   1 
ATOM   404  O  O   . ASP A 1 65  ? -25.854 27.530  30.366  1.00 40.72 ? 70  ASP A O   1 
ATOM   405  C  CB  . ASP A 1 65  ? -26.701 24.760  29.197  1.00 39.56 ? 70  ASP A CB  1 
ATOM   406  C  CG  . ASP A 1 65  ? -26.783 23.249  29.221  1.00 41.21 ? 70  ASP A CG  1 
ATOM   407  O  OD1 . ASP A 1 65  ? -25.754 22.588  29.477  1.00 42.67 ? 70  ASP A OD1 1 
ATOM   408  O  OD2 . ASP A 1 65  ? -27.880 22.709  28.985  1.00 44.90 ? 70  ASP A OD2 1 
ATOM   409  N  N   . LEU A 1 66  ? -24.479 27.214  28.618  1.00 41.30 ? 71  LEU A N   1 
ATOM   410  C  CA  . LEU A 1 66  ? -24.314 28.635  28.386  1.00 42.67 ? 71  LEU A CA  1 
ATOM   411  C  C   . LEU A 1 66  ? -25.532 29.181  27.639  1.00 43.43 ? 71  LEU A C   1 
ATOM   412  O  O   . LEU A 1 66  ? -26.305 28.410  27.061  1.00 43.24 ? 71  LEU A O   1 
ATOM   413  C  CB  . LEU A 1 66  ? -23.017 28.908  27.626  1.00 42.48 ? 71  LEU A CB  1 
ATOM   414  C  CG  . LEU A 1 66  ? -21.712 28.430  28.279  1.00 42.70 ? 71  LEU A CG  1 
ATOM   415  C  CD1 . LEU A 1 66  ? -20.531 28.942  27.458  1.00 42.10 ? 71  LEU A CD1 1 
ATOM   416  C  CD2 . LEU A 1 66  ? -21.565 28.826  29.763  1.00 43.99 ? 71  LEU A CD2 1 
ATOM   417  N  N   . SER A 1 67  ? -25.721 30.499  27.679  1.00 44.70 ? 72  SER A N   1 
ATOM   418  C  CA  . SER A 1 67  ? -26.840 31.140  26.958  1.00 45.65 ? 72  SER A CA  1 
ATOM   419  C  C   . SER A 1 67  ? -26.399 32.360  26.153  1.00 46.19 ? 72  SER A C   1 
ATOM   420  O  O   . SER A 1 67  ? -25.380 32.984  26.463  1.00 46.91 ? 72  SER A O   1 
ATOM   421  C  CB  . SER A 1 67  ? -27.990 31.502  27.910  1.00 45.98 ? 72  SER A CB  1 
ATOM   422  O  OG  . SER A 1 67  ? -27.517 31.936  29.181  1.00 46.79 ? 72  SER A OG  1 
ATOM   423  N  N   . ASP A 1 74  ? -26.845 41.800  13.836  1.00 56.23 ? 79  ASP A N   1 
ATOM   424  C  CA  . ASP A 1 74  ? -25.861 40.901  13.224  1.00 56.04 ? 79  ASP A CA  1 
ATOM   425  C  C   . ASP A 1 74  ? -26.106 40.768  11.722  1.00 55.96 ? 79  ASP A C   1 
ATOM   426  O  O   . ASP A 1 74  ? -26.902 39.930  11.269  1.00 55.79 ? 79  ASP A O   1 
ATOM   427  C  CB  . ASP A 1 74  ? -25.893 39.522  13.899  1.00 55.87 ? 79  ASP A CB  1 
ATOM   428  C  CG  . ASP A 1 74  ? -24.597 38.726  13.702  1.00 55.83 ? 79  ASP A CG  1 
ATOM   429  O  OD1 . ASP A 1 74  ? -23.639 39.211  13.046  1.00 54.40 ? 79  ASP A OD1 1 
ATOM   430  O  OD2 . ASP A 1 74  ? -24.549 37.595  14.222  1.00 54.28 ? 79  ASP A OD2 1 
ATOM   431  N  N   . ASP A 1 75  ? -25.429 41.606  10.946  1.00 55.60 ? 80  ASP A N   1 
ATOM   432  C  CA  . ASP A 1 75  ? -25.648 41.587  9.508   1.00 55.22 ? 80  ASP A CA  1 
ATOM   433  C  C   . ASP A 1 75  ? -24.662 40.654  8.798   1.00 54.69 ? 80  ASP A C   1 
ATOM   434  O  O   . ASP A 1 75  ? -23.524 40.468  9.250   1.00 54.77 ? 80  ASP A O   1 
ATOM   435  C  CB  . ASP A 1 75  ? -25.616 43.001  8.930   1.00 55.42 ? 80  ASP A CB  1 
ATOM   436  C  CG  . ASP A 1 75  ? -26.862 43.320  8.122   1.00 56.28 ? 80  ASP A CG  1 
ATOM   437  O  OD1 . ASP A 1 75  ? -26.788 43.274  6.875   1.00 56.60 ? 80  ASP A OD1 1 
ATOM   438  O  OD2 . ASP A 1 75  ? -27.923 43.591  8.736   1.00 57.00 ? 80  ASP A OD2 1 
ATOM   439  N  N   . LEU A 1 76  ? -25.121 40.065  7.696   1.00 53.79 ? 81  LEU A N   1 
ATOM   440  C  CA  . LEU A 1 76  ? -24.319 39.176  6.856   1.00 53.12 ? 81  LEU A CA  1 
ATOM   441  C  C   . LEU A 1 76  ? -22.957 39.791  6.534   1.00 52.65 ? 81  LEU A C   1 
ATOM   442  O  O   . LEU A 1 76  ? -22.841 41.013  6.399   1.00 52.77 ? 81  LEU A O   1 
ATOM   443  C  CB  . LEU A 1 76  ? -25.051 38.904  5.533   1.00 53.34 ? 81  LEU A CB  1 
ATOM   444  C  CG  . LEU A 1 76  ? -26.395 38.169  5.421   1.00 53.51 ? 81  LEU A CG  1 
ATOM   445  C  CD1 . LEU A 1 76  ? -27.570 38.914  6.071   1.00 53.77 ? 81  LEU A CD1 1 
ATOM   446  C  CD2 . LEU A 1 76  ? -26.684 37.928  3.945   1.00 53.68 ? 81  LEU A CD2 1 
ATOM   447  N  N   . TYR A 1 77  ? -21.929 38.952  6.424   1.00 51.64 ? 82  TYR A N   1 
ATOM   448  C  CA  . TYR A 1 77  ? -20.650 39.385  5.870   1.00 50.69 ? 82  TYR A CA  1 
ATOM   449  C  C   . TYR A 1 77  ? -20.586 39.036  4.384   1.00 50.03 ? 82  TYR A C   1 
ATOM   450  O  O   . TYR A 1 77  ? -20.794 37.883  3.996   1.00 49.49 ? 82  TYR A O   1 
ATOM   451  C  CB  . TYR A 1 77  ? -19.476 38.751  6.612   1.00 50.82 ? 82  TYR A CB  1 
ATOM   452  C  CG  . TYR A 1 77  ? -18.124 39.365  6.287   1.00 50.91 ? 82  TYR A CG  1 
ATOM   453  C  CD1 . TYR A 1 77  ? -17.789 40.646  6.732   1.00 51.31 ? 82  TYR A CD1 1 
ATOM   454  C  CD2 . TYR A 1 77  ? -17.178 38.662  5.544   1.00 51.71 ? 82  TYR A CD2 1 
ATOM   455  C  CE1 . TYR A 1 77  ? -16.544 41.211  6.449   1.00 51.41 ? 82  TYR A CE1 1 
ATOM   456  C  CE2 . TYR A 1 77  ? -15.925 39.218  5.256   1.00 51.83 ? 82  TYR A CE2 1 
ATOM   457  C  CZ  . TYR A 1 77  ? -15.619 40.489  5.713   1.00 52.22 ? 82  TYR A CZ  1 
ATOM   458  O  OH  . TYR A 1 77  ? -14.386 41.039  5.426   1.00 53.24 ? 82  TYR A OH  1 
ATOM   459  N  N   . ASN A 1 78  ? -20.296 40.052  3.570   1.00 49.25 ? 83  ASN A N   1 
ATOM   460  C  CA  . ASN A 1 78  ? -20.212 39.939  2.112   1.00 48.69 ? 83  ASN A CA  1 
ATOM   461  C  C   . ASN A 1 78  ? -21.414 39.256  1.475   1.00 47.82 ? 83  ASN A C   1 
ATOM   462  O  O   . ASN A 1 78  ? -21.259 38.471  0.537   1.00 47.76 ? 83  ASN A O   1 
ATOM   463  C  CB  . ASN A 1 78  ? -18.897 39.267  1.687   1.00 49.24 ? 83  ASN A CB  1 
ATOM   464  C  CG  . ASN A 1 78  ? -17.662 40.034  2.166   1.00 51.10 ? 83  ASN A CG  1 
ATOM   465  O  OD1 . ASN A 1 78  ? -17.733 41.233  2.473   1.00 53.42 ? 83  ASN A OD1 1 
ATOM   466  N  ND2 . ASN A 1 78  ? -16.520 39.343  2.221   1.00 52.21 ? 83  ASN A ND2 1 
ATOM   467  N  N   . ASN A 1 79  ? -22.604 39.553  2.007   1.00 46.68 ? 84  ASN A N   1 
ATOM   468  C  CA  . ASN A 1 79  ? -23.876 38.965  1.553   1.00 45.77 ? 84  ASN A CA  1 
ATOM   469  C  C   . ASN A 1 79  ? -23.952 37.431  1.520   1.00 45.23 ? 84  ASN A C   1 
ATOM   470  O  O   . ASN A 1 79  ? -24.783 36.863  0.801   1.00 44.80 ? 84  ASN A O   1 
ATOM   471  C  CB  . ASN A 1 79  ? -24.304 39.550  0.199   1.00 45.84 ? 84  ASN A CB  1 
ATOM   472  C  CG  . ASN A 1 79  ? -24.717 41.006  0.299   1.00 46.30 ? 84  ASN A CG  1 
ATOM   473  O  OD1 . ASN A 1 79  ? -25.544 41.380  1.140   1.00 46.91 ? 84  ASN A OD1 1 
ATOM   474  N  ND2 . ASN A 1 79  ? -24.135 41.840  -0.555  1.00 46.50 ? 84  ASN A ND2 1 
ATOM   475  N  N   . LEU A 1 80  ? -23.112 36.769  2.321   1.00 44.35 ? 85  LEU A N   1 
ATOM   476  C  CA  . LEU A 1 80  ? -23.091 35.307  2.363   1.00 43.51 ? 85  LEU A CA  1 
ATOM   477  C  C   . LEU A 1 80  ? -23.027 34.723  3.780   1.00 43.01 ? 85  LEU A C   1 
ATOM   478  O  O   . LEU A 1 80  ? -23.868 33.900  4.152   1.00 42.89 ? 85  LEU A O   1 
ATOM   479  C  CB  . LEU A 1 80  ? -21.939 34.775  1.508   1.00 43.46 ? 85  LEU A CB  1 
ATOM   480  C  CG  . LEU A 1 80  ? -21.762 33.257  1.349   1.00 43.04 ? 85  LEU A CG  1 
ATOM   481  C  CD1 . LEU A 1 80  ? -22.906 32.583  0.597   1.00 42.55 ? 85  LEU A CD1 1 
ATOM   482  C  CD2 . LEU A 1 80  ? -20.431 32.989  0.673   1.00 42.54 ? 85  LEU A CD2 1 
ATOM   483  N  N   . ILE A 1 81  ? -22.028 35.142  4.555   1.00 42.50 ? 86  ILE A N   1 
ATOM   484  C  CA  . ILE A 1 81  ? -21.756 34.545  5.869   1.00 42.20 ? 86  ILE A CA  1 
ATOM   485  C  C   . ILE A 1 81  ? -22.772 35.031  6.882   1.00 42.65 ? 86  ILE A C   1 
ATOM   486  O  O   . ILE A 1 81  ? -22.866 36.234  7.161   1.00 42.84 ? 86  ILE A O   1 
ATOM   487  C  CB  . ILE A 1 81  ? -20.330 34.849  6.383   1.00 42.21 ? 86  ILE A CB  1 
ATOM   488  C  CG1 . ILE A 1 81  ? -19.274 34.654  5.283   1.00 41.87 ? 86  ILE A CG1 1 
ATOM   489  C  CG2 . ILE A 1 81  ? -20.021 34.026  7.643   1.00 41.61 ? 86  ILE A CG2 1 
ATOM   490  C  CD1 . ILE A 1 81  ? -19.494 33.451  4.371   1.00 41.61 ? 86  ILE A CD1 1 
ATOM   491  N  N   . VAL A 1 82  ? -23.550 34.092  7.413   1.00 42.85 ? 87  VAL A N   1 
ATOM   492  C  CA  . VAL A 1 82  ? -24.629 34.451  8.323   1.00 42.89 ? 87  VAL A CA  1 
ATOM   493  C  C   . VAL A 1 82  ? -24.133 34.446  9.776   1.00 42.62 ? 87  VAL A C   1 
ATOM   494  O  O   . VAL A 1 82  ? -23.293 33.612  10.151  1.00 42.23 ? 87  VAL A O   1 
ATOM   495  C  CB  . VAL A 1 82  ? -25.903 33.576  8.103   1.00 42.97 ? 87  VAL A CB  1 
ATOM   496  C  CG1 . VAL A 1 82  ? -25.657 32.102  8.446   1.00 43.28 ? 87  VAL A CG1 1 
ATOM   497  C  CG2 . VAL A 1 82  ? -27.096 34.147  8.876   1.00 43.96 ? 87  VAL A CG2 1 
ATOM   498  N  N   . ASN A 1 83  ? -24.637 35.410  10.556  1.00 41.99 ? 88  ASN A N   1 
ATOM   499  C  CA  . ASN A 1 83  ? -24.411 35.508  12.006  1.00 41.40 ? 88  ASN A CA  1 
ATOM   500  C  C   . ASN A 1 83  ? -22.948 35.533  12.442  1.00 40.94 ? 88  ASN A C   1 
ATOM   501  O  O   . ASN A 1 83  ? -22.579 34.873  13.418  1.00 41.38 ? 88  ASN A O   1 
ATOM   502  C  CB  . ASN A 1 83  ? -25.177 34.399  12.742  1.00 41.87 ? 88  ASN A CB  1 
ATOM   503  C  CG  . ASN A 1 83  ? -26.654 34.377  12.379  1.00 41.96 ? 88  ASN A CG  1 
ATOM   504  O  OD1 . ASN A 1 83  ? -27.265 35.423  12.233  1.00 44.11 ? 88  ASN A OD1 1 
ATOM   505  N  ND2 . ASN A 1 83  ? -27.229 33.184  12.235  1.00 42.65 ? 88  ASN A ND2 1 
ATOM   506  N  N   . PRO A 1 84  ? -22.107 36.308  11.740  1.00 40.08 ? 89  PRO A N   1 
ATOM   507  C  CA  . PRO A 1 84  ? -20.701 36.252  12.116  1.00 39.53 ? 89  PRO A CA  1 
ATOM   508  C  C   . PRO A 1 84  ? -20.428 36.782  13.536  1.00 39.16 ? 89  PRO A C   1 
ATOM   509  O  O   . PRO A 1 84  ? -19.670 36.159  14.262  1.00 38.40 ? 89  PRO A O   1 
ATOM   510  C  CB  . PRO A 1 84  ? -20.015 37.102  11.046  1.00 39.78 ? 89  PRO A CB  1 
ATOM   511  C  CG  . PRO A 1 84  ? -21.088 38.014  10.532  1.00 40.13 ? 89  PRO A CG  1 
ATOM   512  C  CD  . PRO A 1 84  ? -22.357 37.249  10.631  1.00 39.83 ? 89  PRO A CD  1 
ATOM   513  N  N   . ARG A 1 85  ? -21.057 37.893  13.936  1.00 38.62 ? 90  ARG A N   1 
ATOM   514  C  CA  . ARG A 1 85  ? -20.841 38.456  15.279  1.00 38.11 ? 90  ARG A CA  1 
ATOM   515  C  C   . ARG A 1 85  ? -21.390 37.587  16.410  1.00 36.97 ? 90  ARG A C   1 
ATOM   516  O  O   . ARG A 1 85  ? -20.730 37.429  17.432  1.00 37.21 ? 90  ARG A O   1 
ATOM   517  C  CB  . ARG A 1 85  ? -21.439 39.865  15.402  1.00 38.70 ? 90  ARG A CB  1 
ATOM   518  C  CG  . ARG A 1 85  ? -20.757 40.914  14.566  1.00 40.61 ? 90  ARG A CG  1 
ATOM   519  C  CD  . ARG A 1 85  ? -21.681 42.121  14.389  1.00 45.64 ? 90  ARG A CD  1 
ATOM   520  N  NE  . ARG A 1 85  ? -21.208 42.997  13.320  1.00 47.24 ? 90  ARG A NE  1 
ATOM   521  C  CZ  . ARG A 1 85  ? -21.464 42.828  12.023  1.00 48.19 ? 90  ARG A CZ  1 
ATOM   522  N  NH1 . ARG A 1 85  ? -22.192 41.796  11.598  1.00 48.39 ? 90  ARG A NH1 1 
ATOM   523  N  NH2 . ARG A 1 85  ? -20.969 43.694  11.144  1.00 48.20 ? 90  ARG A NH2 1 
ATOM   524  N  N   . SER A 1 86  ? -22.596 37.054  16.247  1.00 35.65 ? 91  SER A N   1 
ATOM   525  C  CA  . SER A 1 86  ? -23.162 36.149  17.239  1.00 35.37 ? 91  SER A CA  1 
ATOM   526  C  C   . SER A 1 86  ? -22.287 34.915  17.429  1.00 34.56 ? 91  SER A C   1 
ATOM   527  O  O   . SER A 1 86  ? -22.109 34.445  18.558  1.00 33.97 ? 91  SER A O   1 
ATOM   528  C  CB  . SER A 1 86  ? -24.549 35.687  16.808  1.00 35.47 ? 91  SER A CB  1 
ATOM   529  O  OG  . SER A 1 86  ? -25.429 36.789  16.744  1.00 37.85 ? 91  SER A OG  1 
ATOM   530  N  N   . VAL A 1 87  ? -21.766 34.393  16.316  1.00 33.33 ? 92  VAL A N   1 
ATOM   531  C  CA  . VAL A 1 87  ? -21.004 33.152  16.335  1.00 32.22 ? 92  VAL A CA  1 
ATOM   532  C  C   . VAL A 1 87  ? -19.585 33.407  16.818  1.00 32.28 ? 92  VAL A C   1 
ATOM   533  O  O   . VAL A 1 87  ? -19.078 32.675  17.682  1.00 31.30 ? 92  VAL A O   1 
ATOM   534  C  CB  . VAL A 1 87  ? -21.028 32.427  14.965  1.00 32.48 ? 92  VAL A CB  1 
ATOM   535  C  CG1 . VAL A 1 87  ? -19.913 31.371  14.878  1.00 30.58 ? 92  VAL A CG1 1 
ATOM   536  C  CG2 . VAL A 1 87  ? -22.385 31.793  14.742  1.00 30.85 ? 92  VAL A CG2 1 
ATOM   537  N  N   . GLY A 1 88  ? -18.965 34.465  16.289  1.00 31.47 ? 93  GLY A N   1 
ATOM   538  C  CA  . GLY A 1 88  ? -17.621 34.860  16.714  1.00 32.48 ? 93  GLY A CA  1 
ATOM   539  C  C   . GLY A 1 88  ? -17.541 35.215  18.196  1.00 32.21 ? 93  GLY A C   1 
ATOM   540  O  O   . GLY A 1 88  ? -16.550 34.912  18.859  1.00 31.33 ? 93  GLY A O   1 
ATOM   541  N  N   . LEU A 1 89  ? -18.595 35.850  18.703  1.00 32.34 ? 94  LEU A N   1 
ATOM   542  C  CA  . LEU A 1 89  ? -18.622 36.366  20.070  1.00 32.77 ? 94  LEU A CA  1 
ATOM   543  C  C   . LEU A 1 89  ? -18.960 35.270  21.064  1.00 32.01 ? 94  LEU A C   1 
ATOM   544  O  O   . LEU A 1 89  ? -18.302 35.182  22.109  1.00 31.73 ? 94  LEU A O   1 
ATOM   545  C  CB  . LEU A 1 89  ? -19.606 37.541  20.217  1.00 33.71 ? 94  LEU A CB  1 
ATOM   546  C  CG  . LEU A 1 89  ? -19.144 39.020  20.187  1.00 35.95 ? 94  LEU A CG  1 
ATOM   547  C  CD1 . LEU A 1 89  ? -17.846 39.270  19.396  1.00 37.58 ? 94  LEU A CD1 1 
ATOM   548  C  CD2 . LEU A 1 89  ? -20.281 39.941  19.681  1.00 36.94 ? 94  LEU A CD2 1 
ATOM   549  N  N   . ALA A 1 90  ? -19.971 34.451  20.732  1.00 31.16 ? 95  ALA A N   1 
ATOM   550  C  CA  . ALA A 1 90  ? -20.336 33.263  21.522  1.00 30.59 ? 95  ALA A CA  1 
ATOM   551  C  C   . ALA A 1 90  ? -19.133 32.323  21.669  1.00 30.24 ? 95  ALA A C   1 
ATOM   552  O  O   . ALA A 1 90  ? -18.907 31.723  22.724  1.00 29.96 ? 95  ALA A O   1 
ATOM   553  C  CB  . ALA A 1 90  ? -21.542 32.531  20.906  1.00 30.70 ? 95  ALA A CB  1 
ATOM   554  N  N   . ASN A 1 91  ? -18.334 32.242  20.613  1.00 29.64 ? 96  ASN A N   1 
ATOM   555  C  CA  . ASN A 1 91  ? -17.115 31.449  20.646  1.00 28.43 ? 96  ASN A CA  1 
ATOM   556  C  C   . ASN A 1 91  ? -16.017 32.081  21.493  1.00 28.45 ? 96  ASN A C   1 
ATOM   557  O  O   . ASN A 1 91  ? -15.233 31.368  22.117  1.00 27.40 ? 96  ASN A O   1 
ATOM   558  C  CB  . ASN A 1 91  ? -16.629 31.183  19.230  1.00 28.06 ? 96  ASN A CB  1 
ATOM   559  C  CG  . ASN A 1 91  ? -17.231 29.932  18.659  1.00 26.77 ? 96  ASN A CG  1 
ATOM   560  O  OD1 . ASN A 1 91  ? -17.106 28.859  19.254  1.00 26.19 ? 96  ASN A OD1 1 
ATOM   561  N  ND2 . ASN A 1 91  ? -17.903 30.053  17.523  1.00 24.10 ? 96  ASN A ND2 1 
ATOM   562  N  N   . GLN A 1 92  ? -15.971 33.414  21.534  1.00 27.72 ? 97  GLN A N   1 
ATOM   563  C  CA  . GLN A 1 92  ? -15.041 34.095  22.439  1.00 28.53 ? 97  GLN A CA  1 
ATOM   564  C  C   . GLN A 1 92  ? -15.347 33.721  23.884  1.00 28.35 ? 97  GLN A C   1 
ATOM   565  O  O   . GLN A 1 92  ? -14.429 33.442  24.658  1.00 28.13 ? 97  GLN A O   1 
ATOM   566  C  CB  . GLN A 1 92  ? -15.102 35.625  22.269  1.00 28.93 ? 97  GLN A CB  1 
ATOM   567  C  CG  . GLN A 1 92  ? -13.932 36.344  22.899  1.00 30.81 ? 97  GLN A CG  1 
ATOM   568  C  CD  . GLN A 1 92  ? -13.957 37.848  22.679  1.00 34.61 ? 97  GLN A CD  1 
ATOM   569  O  OE1 . GLN A 1 92  ? -15.016 38.465  22.566  1.00 35.23 ? 97  GLN A OE1 1 
ATOM   570  N  NE2 . GLN A 1 92  ? -12.784 38.438  22.622  1.00 33.91 ? 97  GLN A NE2 1 
ATOM   571  N  N   . GLU A 1 93  ? -16.635 33.705  24.227  1.00 28.24 ? 98  GLU A N   1 
ATOM   572  C  CA  . GLU A 1 93  ? -17.083 33.371  25.581  1.00 28.94 ? 98  GLU A CA  1 
ATOM   573  C  C   . GLU A 1 93  ? -16.818 31.895  25.936  1.00 28.33 ? 98  GLU A C   1 
ATOM   574  O  O   . GLU A 1 93  ? -16.268 31.578  27.012  1.00 28.11 ? 98  GLU A O   1 
ATOM   575  C  CB  . GLU A 1 93  ? -18.566 33.694  25.749  1.00 29.26 ? 98  GLU A CB  1 
ATOM   576  C  CG  . GLU A 1 93  ? -18.913 35.201  25.644  1.00 32.90 ? 98  GLU A CG  1 
ATOM   577  C  CD  . GLU A 1 93  ? -18.039 36.071  26.558  1.00 38.59 ? 98  GLU A CD  1 
ATOM   578  O  OE1 . GLU A 1 93  ? -18.270 36.071  27.792  1.00 40.39 ? 98  GLU A OE1 1 
ATOM   579  O  OE2 . GLU A 1 93  ? -17.109 36.737  26.041  1.00 39.73 ? 98  GLU A OE2 1 
ATOM   580  N  N   . LEU A 1 94  ? -17.165 31.013  24.997  1.00 27.30 ? 99  LEU A N   1 
ATOM   581  C  CA  . LEU A 1 94  ? -16.924 29.598  25.148  1.00 25.86 ? 99  LEU A CA  1 
ATOM   582  C  C   . LEU A 1 94  ? -15.432 29.349  25.327  1.00 26.31 ? 99  LEU A C   1 
ATOM   583  O  O   . LEU A 1 94  ? -15.033 28.538  26.177  1.00 26.38 ? 99  LEU A O   1 
ATOM   584  C  CB  . LEU A 1 94  ? -17.466 28.849  23.928  1.00 25.57 ? 99  LEU A CB  1 
ATOM   585  C  CG  . LEU A 1 94  ? -17.233 27.325  23.853  1.00 23.79 ? 99  LEU A CG  1 
ATOM   586  C  CD1 . LEU A 1 94  ? -17.775 26.591  25.053  1.00 24.68 ? 99  LEU A CD1 1 
ATOM   587  C  CD2 . LEU A 1 94  ? -17.859 26.807  22.596  1.00 21.53 ? 99  LEU A CD2 1 
ATOM   588  N  N   . ALA A 1 95  ? -14.611 30.043  24.539  1.00 25.78 ? 100 ALA A N   1 
ATOM   589  C  CA  . ALA A 1 95  ? -13.161 29.902  24.638  1.00 26.13 ? 100 ALA A CA  1 
ATOM   590  C  C   . ALA A 1 95  ? -12.666 30.162  26.063  1.00 27.30 ? 100 ALA A C   1 
ATOM   591  O  O   . ALA A 1 95  ? -11.727 29.514  26.537  1.00 26.20 ? 100 ALA A O   1 
ATOM   592  C  CB  . ALA A 1 95  ? -12.466 30.834  23.671  1.00 25.90 ? 100 ALA A CB  1 
ATOM   593  N  N   . GLU A 1 96  ? -13.277 31.145  26.721  1.00 28.44 ? 101 GLU A N   1 
ATOM   594  C  CA  . GLU A 1 96  ? -12.901 31.504  28.095  1.00 29.72 ? 101 GLU A CA  1 
ATOM   595  C  C   . GLU A 1 96  ? -13.196 30.402  29.088  1.00 29.07 ? 101 GLU A C   1 
ATOM   596  O  O   . GLU A 1 96  ? -12.347 30.066  29.915  1.00 29.86 ? 101 GLU A O   1 
ATOM   597  C  CB  . GLU A 1 96  ? -13.577 32.823  28.541  1.00 30.01 ? 101 GLU A CB  1 
ATOM   598  C  CG  . GLU A 1 96  ? -12.711 34.041  28.320  1.00 34.34 ? 101 GLU A CG  1 
ATOM   599  C  CD  . GLU A 1 96  ? -11.360 33.949  29.017  1.00 38.03 ? 101 GLU A CD  1 
ATOM   600  O  OE1 . GLU A 1 96  ? -10.363 34.407  28.414  1.00 40.44 ? 101 GLU A OE1 1 
ATOM   601  O  OE2 . GLU A 1 96  ? -11.293 33.414  30.148  1.00 41.08 ? 101 GLU A OE2 1 
ATOM   602  N  N   . VAL A 1 97  ? -14.392 29.836  28.987  1.00 28.74 ? 102 VAL A N   1 
ATOM   603  C  CA  . VAL A 1 97  ? -14.817 28.748  29.855  1.00 28.26 ? 102 VAL A CA  1 
ATOM   604  C  C   . VAL A 1 97  ? -13.898 27.523  29.669  1.00 27.16 ? 102 VAL A C   1 
ATOM   605  O  O   . VAL A 1 97  ? -13.438 26.919  30.648  1.00 26.47 ? 102 VAL A O   1 
ATOM   606  C  CB  . VAL A 1 97  ? -16.306 28.403  29.631  1.00 28.78 ? 102 VAL A CB  1 
ATOM   607  C  CG1 . VAL A 1 97  ? -16.762 27.301  30.582  1.00 29.91 ? 102 VAL A CG1 1 
ATOM   608  C  CG2 . VAL A 1 97  ? -17.186 29.641  29.819  1.00 30.40 ? 102 VAL A CG2 1 
ATOM   609  N  N   . VAL A 1 98  ? -13.623 27.166  28.419  1.00 25.26 ? 103 VAL A N   1 
ATOM   610  C  CA  . VAL A 1 98  ? -12.770 26.008  28.135  1.00 24.29 ? 103 VAL A CA  1 
ATOM   611  C  C   . VAL A 1 98  ? -11.351 26.221  28.671  1.00 24.93 ? 103 VAL A C   1 
ATOM   612  O  O   . VAL A 1 98  ? -10.763 25.317  29.261  1.00 23.07 ? 103 VAL A O   1 
ATOM   613  C  CB  . VAL A 1 98  ? -12.691 25.700  26.601  1.00 24.71 ? 103 VAL A CB  1 
ATOM   614  C  CG1 . VAL A 1 98  ? -11.690 24.557  26.344  1.00 22.72 ? 103 VAL A CG1 1 
ATOM   615  C  CG2 . VAL A 1 98  ? -14.078 25.339  26.057  1.00 21.37 ? 103 VAL A CG2 1 
ATOM   616  N  N   . SER A 1 99  ? -10.804 27.418  28.464  1.00 25.00 ? 104 SER A N   1 
ATOM   617  C  CA  . SER A 1 99  ? -9.457  27.717  28.962  1.00 26.44 ? 104 SER A CA  1 
ATOM   618  C  C   . SER A 1 99  ? -9.408  27.545  30.490  1.00 27.09 ? 104 SER A C   1 
ATOM   619  O  O   . SER A 1 99  ? -8.488  26.922  31.008  1.00 28.03 ? 104 SER A O   1 
ATOM   620  C  CB  . SER A 1 99  ? -9.010  29.137  28.579  1.00 26.67 ? 104 SER A CB  1 
ATOM   621  O  OG  . SER A 1 99  ? -7.616  29.261  28.882  1.00 28.82 ? 104 SER A OG  1 
ATOM   622  N  N   . ARG A 1 100 ? -10.424 28.063  31.177  1.00 27.73 ? 105 ARG A N   1 
ATOM   623  C  CA  . ARG A 1 100 ? -10.582 27.935  32.635  1.00 29.77 ? 105 ARG A CA  1 
ATOM   624  C  C   . ARG A 1 100 ? -10.636 26.483  33.100  1.00 29.46 ? 105 ARG A C   1 
ATOM   625  O  O   . ARG A 1 100 ? -9.919  26.107  34.018  1.00 30.25 ? 105 ARG A O   1 
ATOM   626  C  CB  . ARG A 1 100 ? -11.865 28.628  33.125  1.00 30.18 ? 105 ARG A CB  1 
ATOM   627  C  CG  . ARG A 1 100 ? -11.816 30.150  33.145  1.00 35.29 ? 105 ARG A CG  1 
ATOM   628  C  CD  . ARG A 1 100 ? -12.486 30.769  34.409  1.00 39.99 ? 105 ARG A CD  1 
ATOM   629  N  NE  . ARG A 1 100 ? -13.894 30.415  34.562  1.00 43.41 ? 105 ARG A NE  1 
ATOM   630  C  CZ  . ARG A 1 100 ? -14.407 29.833  35.645  1.00 45.45 ? 105 ARG A CZ  1 
ATOM   631  N  NH1 . ARG A 1 100 ? -15.704 29.539  35.700  1.00 45.87 ? 105 ARG A NH1 1 
ATOM   632  N  NH2 . ARG A 1 100 ? -13.628 29.550  36.680  1.00 45.97 ? 105 ARG A NH2 1 
ATOM   633  N  N   . ALA A 1 101 ? -11.525 25.694  32.486  1.00 28.76 ? 106 ALA A N   1 
ATOM   634  C  CA  . ALA A 1 101 ? -11.670 24.265  32.784  1.00 28.37 ? 106 ALA A CA  1 
ATOM   635  C  C   . ALA A 1 101 ? -10.333 23.510  32.636  1.00 28.23 ? 106 ALA A C   1 
ATOM   636  O  O   . ALA A 1 101 ? -9.936  22.706  33.507  1.00 28.39 ? 106 ALA A O   1 
ATOM   637  C  CB  . ALA A 1 101 ? -12.741 23.660  31.863  1.00 27.62 ? 106 ALA A CB  1 
ATOM   638  N  N   . VAL A 1 102 ? -9.636  23.786  31.538  1.00 27.29 ? 107 VAL A N   1 
ATOM   639  C  CA  . VAL A 1 102 ? -8.410  23.061  31.201  1.00 27.37 ? 107 VAL A CA  1 
ATOM   640  C  C   . VAL A 1 102 ? -7.262  23.476  32.113  1.00 28.09 ? 107 VAL A C   1 
ATOM   641  O  O   . VAL A 1 102 ? -6.460  22.639  32.571  1.00 27.91 ? 107 VAL A O   1 
ATOM   642  C  CB  . VAL A 1 102 ? -8.052  23.261  29.710  1.00 27.57 ? 107 VAL A CB  1 
ATOM   643  C  CG1 . VAL A 1 102 ? -6.618  22.828  29.428  1.00 26.44 ? 107 VAL A CG1 1 
ATOM   644  C  CG2 . VAL A 1 102 ? -9.037  22.484  28.839  1.00 26.23 ? 107 VAL A CG2 1 
ATOM   645  N  N   . SER A 1 103 ? -7.215  24.774  32.390  1.00 28.96 ? 108 SER A N   1 
ATOM   646  C  CA  . SER A 1 103 ? -6.240  25.360  33.320  1.00 30.42 ? 108 SER A CA  1 
ATOM   647  C  C   . SER A 1 103 ? -6.368  24.773  34.737  1.00 30.22 ? 108 SER A C   1 
ATOM   648  O  O   . SER A 1 103 ? -5.361  24.574  35.432  1.00 30.08 ? 108 SER A O   1 
ATOM   649  C  CB  . SER A 1 103 ? -6.379  26.891  33.312  1.00 30.16 ? 108 SER A CB  1 
ATOM   650  O  OG  . SER A 1 103 ? -5.787  27.447  34.468  1.00 33.94 ? 108 SER A OG  1 
ATOM   651  N  N   . ASP A 1 104 ? -7.605  24.474  35.139  1.00 30.30 ? 109 ASP A N   1 
ATOM   652  C  CA  . ASP A 1 104 ? -7.913  23.892  36.441  1.00 30.77 ? 109 ASP A CA  1 
ATOM   653  C  C   . ASP A 1 104 ? -7.742  22.354  36.490  1.00 30.38 ? 109 ASP A C   1 
ATOM   654  O  O   . ASP A 1 104 ? -8.124  21.732  37.474  1.00 29.64 ? 109 ASP A O   1 
ATOM   655  C  CB  . ASP A 1 104 ? -9.359  24.228  36.832  1.00 31.81 ? 109 ASP A CB  1 
ATOM   656  C  CG  . ASP A 1 104 ? -9.563  25.698  37.200  1.00 35.10 ? 109 ASP A CG  1 
ATOM   657  O  OD1 . ASP A 1 104 ? -8.568  26.444  37.318  1.00 38.11 ? 109 ASP A OD1 1 
ATOM   658  O  OD2 . ASP A 1 104 ? -10.738 26.106  37.384  1.00 38.64 ? 109 ASP A OD2 1 
ATOM   659  N  N   . GLY A 1 105 ? -7.180  21.756  35.433  1.00 29.42 ? 110 GLY A N   1 
ATOM   660  C  CA  . GLY A 1 105 ? -6.932  20.315  35.372  1.00 28.35 ? 110 GLY A CA  1 
ATOM   661  C  C   . GLY A 1 105 ? -8.028  19.389  34.858  1.00 28.04 ? 110 GLY A C   1 
ATOM   662  O  O   . GLY A 1 105 ? -7.901  18.168  35.001  1.00 27.44 ? 110 GLY A O   1 
ATOM   663  N  N   . TYR A 1 106 ? -9.105  19.944  34.277  1.00 26.67 ? 111 TYR A N   1 
ATOM   664  C  CA  . TYR A 1 106 ? -10.196 19.130  33.716  1.00 25.53 ? 111 TYR A CA  1 
ATOM   665  C  C   . TYR A 1 106 ? -9.982  18.813  32.224  1.00 24.51 ? 111 TYR A C   1 
ATOM   666  O  O   . TYR A 1 106 ? -9.523  19.659  31.459  1.00 24.21 ? 111 TYR A O   1 
ATOM   667  C  CB  . TYR A 1 106 ? -11.578 19.806  33.902  1.00 25.25 ? 111 TYR A CB  1 
ATOM   668  C  CG  . TYR A 1 106 ? -12.020 19.902  35.355  1.00 26.24 ? 111 TYR A CG  1 
ATOM   669  C  CD1 . TYR A 1 106 ? -11.769 21.055  36.101  1.00 27.08 ? 111 TYR A CD1 1 
ATOM   670  C  CD2 . TYR A 1 106 ? -12.663 18.828  35.991  1.00 25.96 ? 111 TYR A CD2 1 
ATOM   671  C  CE1 . TYR A 1 106 ? -12.153 21.134  37.446  1.00 28.15 ? 111 TYR A CE1 1 
ATOM   672  C  CE2 . TYR A 1 106 ? -13.042 18.895  37.327  1.00 27.28 ? 111 TYR A CE2 1 
ATOM   673  C  CZ  . TYR A 1 106 ? -12.781 20.060  38.047  1.00 28.82 ? 111 TYR A CZ  1 
ATOM   674  O  OH  . TYR A 1 106 ? -13.149 20.139  39.385  1.00 30.23 ? 111 TYR A OH  1 
ATOM   675  N  N   . SER A 1 107 ? -10.325 17.591  31.825  1.00 22.58 ? 112 SER A N   1 
ATOM   676  C  CA  . SER A 1 107 ? -10.592 17.292  30.430  1.00 21.37 ? 112 SER A CA  1 
ATOM   677  C  C   . SER A 1 107 ? -11.960 17.882  30.106  1.00 19.94 ? 112 SER A C   1 
ATOM   678  O  O   . SER A 1 107 ? -12.948 17.517  30.731  1.00 18.45 ? 112 SER A O   1 
ATOM   679  C  CB  . SER A 1 107 ? -10.590 15.770  30.184  1.00 21.41 ? 112 SER A CB  1 
ATOM   680  O  OG  . SER A 1 107 ? -9.305  15.258  30.497  1.00 24.32 ? 112 SER A OG  1 
ATOM   681  N  N   . CYS A 1 108 ? -11.995 18.812  29.158  1.00 19.46 ? 113 CYS A N   1 
ATOM   682  C  CA  . CYS A 1 108 ? -13.185 19.629  28.922  1.00 20.03 ? 113 CYS A CA  1 
ATOM   683  C  C   . CYS A 1 108 ? -14.082 19.061  27.818  1.00 19.38 ? 113 CYS A C   1 
ATOM   684  O  O   . CYS A 1 108 ? -13.713 19.089  26.646  1.00 19.18 ? 113 CYS A O   1 
ATOM   685  C  CB  . CYS A 1 108 ? -12.780 21.073  28.596  1.00 20.22 ? 113 CYS A CB  1 
ATOM   686  S  SG  . CYS A 1 108 ? -14.204 22.193  28.576  1.00 24.34 ? 113 CYS A SG  1 
ATOM   687  N  N   . VAL A 1 109 ? -15.252 18.556  28.212  1.00 18.80 ? 114 VAL A N   1 
ATOM   688  C  CA  . VAL A 1 109 ? -16.255 18.077  27.292  1.00 17.82 ? 114 VAL A CA  1 
ATOM   689  C  C   . VAL A 1 109 ? -17.256 19.195  26.991  1.00 18.48 ? 114 VAL A C   1 
ATOM   690  O  O   . VAL A 1 109 ? -17.910 19.714  27.915  1.00 17.67 ? 114 VAL A O   1 
ATOM   691  C  CB  . VAL A 1 109 ? -17.051 16.886  27.877  1.00 18.38 ? 114 VAL A CB  1 
ATOM   692  C  CG1 . VAL A 1 109 ? -18.242 16.529  26.975  1.00 18.90 ? 114 VAL A CG1 1 
ATOM   693  C  CG2 . VAL A 1 109 ? -16.161 15.673  28.097  1.00 18.84 ? 114 VAL A CG2 1 
ATOM   694  N  N   . THR A 1 110 ? -17.370 19.556  25.715  1.00 17.51 ? 115 THR A N   1 
ATOM   695  C  CA  . THR A 1 110 ? -18.402 20.505  25.269  1.00 18.52 ? 115 THR A CA  1 
ATOM   696  C  C   . THR A 1 110 ? -19.462 19.823  24.420  1.00 18.03 ? 115 THR A C   1 
ATOM   697  O  O   . THR A 1 110 ? -19.154 19.144  23.415  1.00 16.67 ? 115 THR A O   1 
ATOM   698  C  CB  . THR A 1 110 ? -17.780 21.659  24.460  1.00 18.70 ? 115 THR A CB  1 
ATOM   699  O  OG1 . THR A 1 110 ? -16.738 22.271  25.227  1.00 19.94 ? 115 THR A OG1 1 
ATOM   700  C  CG2 . THR A 1 110 ? -18.839 22.713  24.081  1.00 18.27 ? 115 THR A CG2 1 
ATOM   701  N  N   . LEU A 1 111 ? -20.716 20.001  24.827  1.00 18.40 ? 116 LEU A N   1 
ATOM   702  C  CA  . LEU A 1 111 ? -21.854 19.473  24.078  1.00 18.19 ? 116 LEU A CA  1 
ATOM   703  C  C   . LEU A 1 111 ? -22.404 20.549  23.161  1.00 19.26 ? 116 LEU A C   1 
ATOM   704  O  O   . LEU A 1 111 ? -22.738 21.655  23.627  1.00 21.12 ? 116 LEU A O   1 
ATOM   705  C  CB  . LEU A 1 111 ? -22.972 18.994  25.024  1.00 17.99 ? 116 LEU A CB  1 
ATOM   706  C  CG  . LEU A 1 111 ? -22.517 18.129  26.205  1.00 17.89 ? 116 LEU A CG  1 
ATOM   707  C  CD1 . LEU A 1 111 ? -23.690 17.854  27.179  1.00 16.75 ? 116 LEU A CD1 1 
ATOM   708  C  CD2 . LEU A 1 111 ? -21.878 16.811  25.726  1.00 15.41 ? 116 LEU A CD2 1 
ATOM   709  N  N   . GLY A 1 112 ? -22.512 20.237  21.864  1.00 18.23 ? 117 GLY A N   1 
ATOM   710  C  CA  . GLY A 1 112 ? -23.126 21.164  20.915  1.00 18.71 ? 117 GLY A CA  1 
ATOM   711  C  C   . GLY A 1 112 ? -24.589 20.809  20.703  1.00 17.98 ? 117 GLY A C   1 
ATOM   712  O  O   . GLY A 1 112 ? -25.037 19.788  21.192  1.00 17.14 ? 117 GLY A O   1 
ATOM   713  N  N   . GLY A 1 113 ? -25.337 21.621  19.947  1.00 18.92 ? 118 GLY A N   1 
ATOM   714  C  CA  . GLY A 1 113 ? -24.794 22.777  19.233  1.00 19.24 ? 118 GLY A CA  1 
ATOM   715  C  C   . GLY A 1 113 ? -24.039 22.404  17.958  1.00 19.96 ? 118 GLY A C   1 
ATOM   716  O  O   . GLY A 1 113 ? -23.535 21.278  17.822  1.00 20.63 ? 118 GLY A O   1 
ATOM   717  N  N   . ASP A 1 114 ? -23.989 23.332  17.007  1.00 19.05 ? 119 ASP A N   1 
ATOM   718  C  CA  . ASP A 1 114 ? -23.439 23.033  15.700  1.00 19.27 ? 119 ASP A CA  1 
ATOM   719  C  C   . ASP A 1 114 ? -21.914 23.139  15.776  1.00 18.85 ? 119 ASP A C   1 
ATOM   720  O  O   . ASP A 1 114 ? -21.368 23.671  16.733  1.00 19.03 ? 119 ASP A O   1 
ATOM   721  C  CB  . ASP A 1 114 ? -23.993 23.975  14.620  1.00 19.14 ? 119 ASP A CB  1 
ATOM   722  C  CG  . ASP A 1 114 ? -23.531 25.406  14.804  1.00 21.88 ? 119 ASP A CG  1 
ATOM   723  O  OD1 . ASP A 1 114 ? -22.309 25.676  14.777  1.00 22.36 ? 119 ASP A OD1 1 
ATOM   724  O  OD2 . ASP A 1 114 ? -24.403 26.275  15.002  1.00 28.03 ? 119 ASP A OD2 1 
ATOM   725  N  N   . HIS A 1 115 ? -21.252 22.651  14.745  1.00 18.83 ? 120 HIS A N   1 
ATOM   726  C  CA  . HIS A 1 115 ? -19.785 22.523  14.769  1.00 18.04 ? 120 HIS A CA  1 
ATOM   727  C  C   . HIS A 1 115 ? -18.993 23.812  14.746  1.00 18.87 ? 120 HIS A C   1 
ATOM   728  O  O   . HIS A 1 115 ? -17.769 23.801  14.988  1.00 18.17 ? 120 HIS A O   1 
ATOM   729  C  CB  . HIS A 1 115 ? -19.311 21.574  13.685  1.00 16.61 ? 120 HIS A CB  1 
ATOM   730  C  CG  . HIS A 1 115 ? -18.171 20.706  14.111  1.00 18.50 ? 120 HIS A CG  1 
ATOM   731  N  ND1 . HIS A 1 115 ? -17.908 19.487  13.527  1.00 16.30 ? 120 HIS A ND1 1 
ATOM   732  C  CD2 . HIS A 1 115 ? -17.243 20.862  15.088  1.00 17.71 ? 120 HIS A CD2 1 
ATOM   733  C  CE1 . HIS A 1 115 ? -16.857 18.938  14.106  1.00 16.51 ? 120 HIS A CE1 1 
ATOM   734  N  NE2 . HIS A 1 115 ? -16.449 19.740  15.076  1.00 16.12 ? 120 HIS A NE2 1 
ATOM   735  N  N   . SER A 1 116 ? -19.662 24.940  14.527  1.00 19.94 ? 121 SER A N   1 
ATOM   736  C  CA  . SER A 1 116 ? -18.976 26.222  14.637  1.00 20.55 ? 121 SER A CA  1 
ATOM   737  C  C   . SER A 1 116 ? -18.396 26.435  16.034  1.00 19.98 ? 121 SER A C   1 
ATOM   738  O  O   . SER A 1 116 ? -17.433 27.184  16.185  1.00 19.57 ? 121 SER A O   1 
ATOM   739  C  CB  . SER A 1 116 ? -19.902 27.394  14.284  1.00 21.81 ? 121 SER A CB  1 
ATOM   740  O  OG  . SER A 1 116 ? -20.866 27.584  15.313  1.00 23.04 ? 121 SER A OG  1 
ATOM   741  N  N   . LEU A 1 117 ? -18.962 25.771  17.046  1.00 18.62 ? 122 LEU A N   1 
ATOM   742  C  CA  . LEU A 1 117 ? -18.432 25.886  18.415  1.00 19.07 ? 122 LEU A CA  1 
ATOM   743  C  C   . LEU A 1 117 ? -16.950 25.448  18.596  1.00 18.85 ? 122 LEU A C   1 
ATOM   744  O  O   . LEU A 1 117 ? -16.315 25.846  19.577  1.00 17.10 ? 122 LEU A O   1 
ATOM   745  C  CB  . LEU A 1 117 ? -19.342 25.187  19.443  1.00 19.98 ? 122 LEU A CB  1 
ATOM   746  C  CG  . LEU A 1 117 ? -19.399 23.652  19.485  1.00 20.23 ? 122 LEU A CG  1 
ATOM   747  C  CD1 . LEU A 1 117 ? -18.247 23.059  20.303  1.00 20.93 ? 122 LEU A CD1 1 
ATOM   748  C  CD2 . LEU A 1 117 ? -20.724 23.218  20.066  1.00 20.40 ? 122 LEU A CD2 1 
ATOM   749  N  N   . ALA A 1 118 ? -16.409 24.630  17.682  1.00 17.51 ? 123 ALA A N   1 
ATOM   750  C  CA  . ALA A 1 118 ? -14.981 24.213  17.794  1.00 17.45 ? 123 ALA A CA  1 
ATOM   751  C  C   . ALA A 1 118 ? -13.979 25.356  17.634  1.00 17.10 ? 123 ALA A C   1 
ATOM   752  O  O   . ALA A 1 118 ? -12.801 25.248  18.046  1.00 17.59 ? 123 ALA A O   1 
ATOM   753  C  CB  . ALA A 1 118 ? -14.638 23.097  16.807  1.00 16.54 ? 123 ALA A CB  1 
ATOM   754  N  N   . ILE A 1 119 ? -14.415 26.426  16.992  1.00 17.66 ? 124 ILE A N   1 
ATOM   755  C  CA  . ILE A 1 119 ? -13.646 27.675  16.955  1.00 18.49 ? 124 ILE A CA  1 
ATOM   756  C  C   . ILE A 1 119 ? -13.301 28.078  18.397  1.00 19.03 ? 124 ILE A C   1 
ATOM   757  O  O   . ILE A 1 119 ? -12.114 28.257  18.735  1.00 18.98 ? 124 ILE A O   1 
ATOM   758  C  CB  . ILE A 1 119 ? -14.444 28.805  16.237  1.00 18.18 ? 124 ILE A CB  1 
ATOM   759  C  CG1 . ILE A 1 119 ? -14.550 28.515  14.727  1.00 19.55 ? 124 ILE A CG1 1 
ATOM   760  C  CG2 . ILE A 1 119 ? -13.758 30.146  16.426  1.00 18.02 ? 124 ILE A CG2 1 
ATOM   761  C  CD1 . ILE A 1 119 ? -15.665 29.338  13.985  1.00 20.86 ? 124 ILE A CD1 1 
ATOM   762  N  N   . GLY A 1 120 ? -14.333 28.156  19.235  1.00 18.71 ? 125 GLY A N   1 
ATOM   763  C  CA  . GLY A 1 120 ? -14.167 28.500  20.662  1.00 20.10 ? 125 GLY A CA  1 
ATOM   764  C  C   . GLY A 1 120 ? -13.436 27.449  21.486  1.00 19.68 ? 125 GLY A C   1 
ATOM   765  O  O   . GLY A 1 120 ? -12.502 27.783  22.239  1.00 19.64 ? 125 GLY A O   1 
ATOM   766  N  N   . THR A 1 121 ? -13.836 26.178  21.357  1.00 19.12 ? 126 THR A N   1 
ATOM   767  C  CA  . THR A 1 121 ? -13.271 25.147  22.261  1.00 18.19 ? 126 THR A CA  1 
ATOM   768  C  C   . THR A 1 121 ? -11.785 24.956  21.921  1.00 19.08 ? 126 THR A C   1 
ATOM   769  O  O   . THR A 1 121 ? -10.947 24.834  22.810  1.00 19.80 ? 126 THR A O   1 
ATOM   770  C  CB  . THR A 1 121 ? -14.016 23.790  22.176  1.00 17.57 ? 126 THR A CB  1 
ATOM   771  O  OG1 . THR A 1 121 ? -13.810 23.219  20.870  1.00 16.98 ? 126 THR A OG1 1 
ATOM   772  C  CG2 . THR A 1 121 ? -15.554 23.969  22.448  1.00 16.20 ? 126 THR A CG2 1 
ATOM   773  N  N   . ILE A 1 122 ? -11.452 24.934  20.633  1.00 19.51 ? 127 ILE A N   1 
ATOM   774  C  CA  . ILE A 1 122 ? -10.048 24.705  20.273  1.00 19.42 ? 127 ILE A CA  1 
ATOM   775  C  C   . ILE A 1 122 ? -9.187  25.919  20.645  1.00 20.41 ? 127 ILE A C   1 
ATOM   776  O  O   . ILE A 1 122 ? -8.092  25.745  21.184  1.00 19.78 ? 127 ILE A O   1 
ATOM   777  C  CB  . ILE A 1 122 ? -9.857  24.246  18.803  1.00 19.38 ? 127 ILE A CB  1 
ATOM   778  C  CG1 . ILE A 1 122 ? -10.459 22.842  18.633  1.00 17.43 ? 127 ILE A CG1 1 
ATOM   779  C  CG2 . ILE A 1 122 ? -8.334  24.178  18.412  1.00 17.60 ? 127 ILE A CG2 1 
ATOM   780  C  CD1 . ILE A 1 122 ? -10.571 22.338  17.163  1.00 18.36 ? 127 ILE A CD1 1 
ATOM   781  N  N   . SER A 1 123 ? -9.684  27.127  20.356  1.00 21.87 ? 128 SER A N   1 
ATOM   782  C  CA  . SER A 1 123 ? -8.933  28.366  20.678  1.00 23.11 ? 128 SER A CA  1 
ATOM   783  C  C   . SER A 1 123 ? -8.690  28.405  22.182  1.00 22.96 ? 128 SER A C   1 
ATOM   784  O  O   . SER A 1 123 ? -7.563  28.584  22.621  1.00 23.20 ? 128 SER A O   1 
ATOM   785  C  CB  . SER A 1 123 ? -9.696  29.628  20.251  1.00 23.09 ? 128 SER A CB  1 
ATOM   786  O  OG  . SER A 1 123 ? -9.939  29.654  18.850  1.00 27.64 ? 128 SER A OG  1 
ATOM   787  N  N   . GLY A 1 124 ? -9.750  28.205  22.971  1.00 23.24 ? 129 GLY A N   1 
ATOM   788  C  CA  . GLY A 1 124 ? -9.610  28.195  24.444  1.00 23.81 ? 129 GLY A CA  1 
ATOM   789  C  C   . GLY A 1 124 ? -8.659  27.128  24.976  1.00 24.00 ? 129 GLY A C   1 
ATOM   790  O  O   . GLY A 1 124 ? -7.867  27.374  25.886  1.00 24.26 ? 129 GLY A O   1 
ATOM   791  N  N   . HIS A 1 125 ? -8.763  25.929  24.417  1.00 22.62 ? 130 HIS A N   1 
ATOM   792  C  CA  . HIS A 1 125 ? -7.918  24.815  24.803  1.00 22.16 ? 130 HIS A CA  1 
ATOM   793  C  C   . HIS A 1 125 ? -6.439  25.173  24.577  1.00 21.98 ? 130 HIS A C   1 
ATOM   794  O  O   . HIS A 1 125 ? -5.593  24.907  25.450  1.00 22.19 ? 130 HIS A O   1 
ATOM   795  C  CB  . HIS A 1 125 ? -8.320  23.578  23.964  1.00 21.00 ? 130 HIS A CB  1 
ATOM   796  C  CG  . HIS A 1 125 ? -7.720  22.291  24.433  1.00 20.93 ? 130 HIS A CG  1 
ATOM   797  N  ND1 . HIS A 1 125 ? -7.960  21.097  23.790  1.00 17.45 ? 130 HIS A ND1 1 
ATOM   798  C  CD2 . HIS A 1 125 ? -6.838  22.014  25.430  1.00 21.47 ? 130 HIS A CD2 1 
ATOM   799  C  CE1 . HIS A 1 125 ? -7.306  20.128  24.407  1.00 21.74 ? 130 HIS A CE1 1 
ATOM   800  N  NE2 . HIS A 1 125 ? -6.603  20.660  25.396  1.00 22.45 ? 130 HIS A NE2 1 
ATOM   801  N  N   . ALA A 1 126 ? -6.162  25.815  23.437  1.00 22.39 ? 131 ALA A N   1 
ATOM   802  C  CA  . ALA A 1 126 ? -4.789  26.149  22.999  1.00 23.96 ? 131 ALA A CA  1 
ATOM   803  C  C   . ALA A 1 126 ? -4.104  27.203  23.870  1.00 24.94 ? 131 ALA A C   1 
ATOM   804  O  O   . ALA A 1 126 ? -2.874  27.320  23.842  1.00 25.27 ? 131 ALA A O   1 
ATOM   805  C  CB  . ALA A 1 126 ? -4.785  26.615  21.537  1.00 23.10 ? 131 ALA A CB  1 
ATOM   806  N  N   . ARG A 1 127 ? -4.879  27.979  24.618  1.00 26.59 ? 132 ARG A N   1 
ATOM   807  C  CA  . ARG A 1 127 ? -4.283  29.017  25.483  1.00 28.51 ? 132 ARG A CA  1 
ATOM   808  C  C   . ARG A 1 127 ? -3.457  28.388  26.579  1.00 28.82 ? 132 ARG A C   1 
ATOM   809  O  O   . ARG A 1 127 ? -2.411  28.901  26.949  1.00 29.68 ? 132 ARG A O   1 
ATOM   810  C  CB  . ARG A 1 127 ? -5.347  29.915  26.107  1.00 28.93 ? 132 ARG A CB  1 
ATOM   811  C  CG  . ARG A 1 127 ? -6.163  30.605  25.089  1.00 30.99 ? 132 ARG A CG  1 
ATOM   812  C  CD  . ARG A 1 127 ? -6.835  31.842  25.613  1.00 33.32 ? 132 ARG A CD  1 
ATOM   813  N  NE  . ARG A 1 127 ? -7.629  32.394  24.529  1.00 35.30 ? 132 ARG A NE  1 
ATOM   814  C  CZ  . ARG A 1 127 ? -8.894  32.778  24.627  1.00 36.55 ? 132 ARG A CZ  1 
ATOM   815  N  NH1 . ARG A 1 127 ? -9.537  32.722  25.794  1.00 37.58 ? 132 ARG A NH1 1 
ATOM   816  N  NH2 . ARG A 1 127 ? -9.503  33.262  23.551  1.00 35.78 ? 132 ARG A NH2 1 
ATOM   817  N  N   . HIS A 1 128 ? -3.925  27.265  27.094  1.00 28.77 ? 133 HIS A N   1 
ATOM   818  C  CA  . HIS A 1 128 ? -3.199  26.554  28.120  1.00 30.00 ? 133 HIS A CA  1 
ATOM   819  C  C   . HIS A 1 128 ? -2.364  25.423  27.510  1.00 29.78 ? 133 HIS A C   1 
ATOM   820  O  O   . HIS A 1 128 ? -1.334  25.029  28.066  1.00 30.15 ? 133 HIS A O   1 
ATOM   821  C  CB  . HIS A 1 128 ? -4.185  25.989  29.150  1.00 30.52 ? 133 HIS A CB  1 
ATOM   822  C  CG  . HIS A 1 128 ? -3.524  25.429  30.368  1.00 32.79 ? 133 HIS A CG  1 
ATOM   823  N  ND1 . HIS A 1 128 ? -3.352  24.072  30.573  1.00 36.11 ? 133 HIS A ND1 1 
ATOM   824  C  CD2 . HIS A 1 128 ? -2.973  26.044  31.442  1.00 34.25 ? 133 HIS A CD2 1 
ATOM   825  C  CE1 . HIS A 1 128 ? -2.729  23.878  31.724  1.00 34.79 ? 133 HIS A CE1 1 
ATOM   826  N  NE2 . HIS A 1 128 ? -2.496  25.059  32.273  1.00 36.37 ? 133 HIS A NE2 1 
ATOM   827  N  N   . CYS A 1 129 ? -2.828  24.871  26.386  1.00 29.14 ? 134 CYS A N   1 
ATOM   828  C  CA  . CYS A 1 129 ? -2.140  23.747  25.749  1.00 29.01 ? 134 CYS A CA  1 
ATOM   829  C  C   . CYS A 1 129 ? -1.721  24.094  24.318  1.00 29.05 ? 134 CYS A C   1 
ATOM   830  O  O   . CYS A 1 129 ? -2.312  23.570  23.341  1.00 28.72 ? 134 CYS A O   1 
ATOM   831  C  CB  . CYS A 1 129 ? -3.043  22.510  25.765  1.00 29.51 ? 134 CYS A CB  1 
ATOM   832  S  SG  . CYS A 1 129 ? -3.615  22.054  27.416  1.00 30.48 ? 134 CYS A SG  1 
ATOM   833  N  N   . PRO A 1 130 ? -0.696  24.978  24.175  1.00 28.12 ? 135 PRO A N   1 
ATOM   834  C  CA  . PRO A 1 130 ? -0.239  25.419  22.861  1.00 27.42 ? 135 PRO A CA  1 
ATOM   835  C  C   . PRO A 1 130 ? 0.222   24.263  21.953  1.00 26.27 ? 135 PRO A C   1 
ATOM   836  O  O   . PRO A 1 130 ? 0.163   24.388  20.747  1.00 26.00 ? 135 PRO A O   1 
ATOM   837  C  CB  . PRO A 1 130 ? 0.951   26.353  23.198  1.00 28.18 ? 135 PRO A CB  1 
ATOM   838  C  CG  . PRO A 1 130 ? 1.392   25.933  24.581  1.00 28.10 ? 135 PRO A CG  1 
ATOM   839  C  CD  . PRO A 1 130 ? 0.073   25.635  25.251  1.00 28.03 ? 135 PRO A CD  1 
ATOM   840  N  N   . ASP A 1 131 ? 0.665   23.148  22.533  1.00 25.51 ? 136 ASP A N   1 
ATOM   841  C  CA  . ASP A 1 131 ? 1.149   22.026  21.738  1.00 24.09 ? 136 ASP A CA  1 
ATOM   842  C  C   . ASP A 1 131 ? 0.054   20.960  21.460  1.00 22.88 ? 136 ASP A C   1 
ATOM   843  O  O   . ASP A 1 131 ? 0.367   19.817  21.135  1.00 21.03 ? 136 ASP A O   1 
ATOM   844  C  CB  . ASP A 1 131 ? 2.389   21.389  22.384  1.00 24.17 ? 136 ASP A CB  1 
ATOM   845  C  CG  . ASP A 1 131 ? 3.152   20.473  21.416  1.00 26.02 ? 136 ASP A CG  1 
ATOM   846  O  OD1 . ASP A 1 131 ? 3.878   19.556  21.870  1.00 28.10 ? 136 ASP A OD1 1 
ATOM   847  O  OD2 . ASP A 1 131 ? 3.020   20.657  20.193  1.00 29.56 ? 136 ASP A OD2 1 
ATOM   848  N  N   . LEU A 1 132 ? -1.215  21.341  21.566  1.00 21.75 ? 137 LEU A N   1 
ATOM   849  C  CA  . LEU A 1 132 ? -2.291  20.352  21.410  1.00 21.37 ? 137 LEU A CA  1 
ATOM   850  C  C   . LEU A 1 132 ? -2.345  19.841  19.960  1.00 20.75 ? 137 LEU A C   1 
ATOM   851  O  O   . LEU A 1 132 ? -1.867  20.502  19.012  1.00 19.72 ? 137 LEU A O   1 
ATOM   852  C  CB  . LEU A 1 132 ? -3.665  20.938  21.846  1.00 21.01 ? 137 LEU A CB  1 
ATOM   853  C  CG  . LEU A 1 132 ? -4.316  22.070  21.026  1.00 22.43 ? 137 LEU A CG  1 
ATOM   854  C  CD1 . LEU A 1 132 ? -4.604  21.686  19.614  1.00 27.91 ? 137 LEU A CD1 1 
ATOM   855  C  CD2 . LEU A 1 132 ? -5.621  22.466  21.641  1.00 24.59 ? 137 LEU A CD2 1 
ATOM   856  N  N   . CYS A 1 133 ? -2.950  18.669  19.772  1.00 20.09 ? 138 CYS A N   1 
ATOM   857  C  CA  . CYS A 1 133 ? -3.269  18.206  18.426  1.00 18.84 ? 138 CYS A CA  1 
ATOM   858  C  C   . CYS A 1 133 ? -4.785  17.965  18.346  1.00 18.88 ? 138 CYS A C   1 
ATOM   859  O  O   . CYS A 1 133 ? -5.471  17.906  19.386  1.00 18.99 ? 138 CYS A O   1 
ATOM   860  C  CB  . CYS A 1 133 ? -2.496  16.917  18.091  1.00 18.89 ? 138 CYS A CB  1 
ATOM   861  S  SG  . CYS A 1 133 ? -2.739  15.553  19.254  1.00 22.02 ? 138 CYS A SG  1 
ATOM   862  N  N   . VAL A 1 134 ? -5.296  17.821  17.131  1.00 17.06 ? 139 VAL A N   1 
ATOM   863  C  CA  . VAL A 1 134 ? -6.749  17.730  16.961  1.00 16.10 ? 139 VAL A CA  1 
ATOM   864  C  C   . VAL A 1 134 ? -7.080  16.465  16.169  1.00 15.97 ? 139 VAL A C   1 
ATOM   865  O  O   . VAL A 1 134 ? -6.485  16.210  15.124  1.00 15.32 ? 139 VAL A O   1 
ATOM   866  C  CB  . VAL A 1 134 ? -7.322  18.964  16.243  1.00 15.99 ? 139 VAL A CB  1 
ATOM   867  C  CG1 . VAL A 1 134 ? -8.860  18.791  15.971  1.00 15.54 ? 139 VAL A CG1 1 
ATOM   868  C  CG2 . VAL A 1 134 ? -7.072  20.283  17.066  1.00 13.50 ? 139 VAL A CG2 1 
ATOM   869  N  N   . VAL A 1 135 ? -8.025  15.675  16.681  1.00 15.41 ? 140 VAL A N   1 
ATOM   870  C  CA  . VAL A 1 135 ? -8.550  14.559  15.922  1.00 14.66 ? 140 VAL A CA  1 
ATOM   871  C  C   . VAL A 1 135 ? -9.987  14.979  15.597  1.00 14.48 ? 140 VAL A C   1 
ATOM   872  O  O   . VAL A 1 135 ? -10.790 15.165  16.503  1.00 14.34 ? 140 VAL A O   1 
ATOM   873  C  CB  . VAL A 1 135 ? -8.534  13.255  16.728  1.00 14.17 ? 140 VAL A CB  1 
ATOM   874  C  CG1 . VAL A 1 135 ? -9.261  12.159  15.943  1.00 14.32 ? 140 VAL A CG1 1 
ATOM   875  C  CG2 . VAL A 1 135 ? -7.054  12.830  17.047  1.00 15.99 ? 140 VAL A CG2 1 
ATOM   876  N  N   . TRP A 1 136 ? -10.267 15.142  14.308  1.00 14.04 ? 141 TRP A N   1 
ATOM   877  C  CA  . TRP A 1 136 ? -11.536 15.671  13.828  1.00 14.89 ? 141 TRP A CA  1 
ATOM   878  C  C   . TRP A 1 136 ? -12.338 14.551  13.144  1.00 14.10 ? 141 TRP A C   1 
ATOM   879  O  O   . TRP A 1 136 ? -12.049 14.152  12.009  1.00 14.57 ? 141 TRP A O   1 
ATOM   880  C  CB  . TRP A 1 136 ? -11.272 16.859  12.882  1.00 14.20 ? 141 TRP A CB  1 
ATOM   881  C  CG  . TRP A 1 136 ? -12.487 17.723  12.561  1.00 17.05 ? 141 TRP A CG  1 
ATOM   882  C  CD1 . TRP A 1 136 ? -13.545 17.395  11.755  1.00 15.72 ? 141 TRP A CD1 1 
ATOM   883  C  CD2 . TRP A 1 136 ? -12.744 19.059  13.035  1.00 17.74 ? 141 TRP A CD2 1 
ATOM   884  N  NE1 . TRP A 1 136 ? -14.437 18.441  11.696  1.00 16.84 ? 141 TRP A NE1 1 
ATOM   885  C  CE2 . TRP A 1 136 ? -13.986 19.463  12.489  1.00 16.18 ? 141 TRP A CE2 1 
ATOM   886  C  CE3 . TRP A 1 136 ? -12.058 19.937  13.891  1.00 16.92 ? 141 TRP A CE3 1 
ATOM   887  C  CZ2 . TRP A 1 136 ? -14.560 20.723  12.752  1.00 17.33 ? 141 TRP A CZ2 1 
ATOM   888  C  CZ3 . TRP A 1 136 ? -12.633 21.191  14.170  1.00 16.22 ? 141 TRP A CZ3 1 
ATOM   889  C  CH2 . TRP A 1 136 ? -13.869 21.569  13.593  1.00 19.01 ? 141 TRP A CH2 1 
ATOM   890  N  N   . VAL A 1 137 ? -13.376 14.074  13.821  1.00 14.38 ? 142 VAL A N   1 
ATOM   891  C  CA  . VAL A 1 137 ? -14.099 12.901  13.368  1.00 13.70 ? 142 VAL A CA  1 
ATOM   892  C  C   . VAL A 1 137 ? -15.437 13.419  12.890  1.00 13.39 ? 142 VAL A C   1 
ATOM   893  O  O   . VAL A 1 137 ? -16.210 13.976  13.682  1.00 12.64 ? 142 VAL A O   1 
ATOM   894  C  CB  . VAL A 1 137 ? -14.338 11.886  14.527  1.00 14.95 ? 142 VAL A CB  1 
ATOM   895  C  CG1 . VAL A 1 137 ? -15.109 10.671  14.015  1.00 14.16 ? 142 VAL A CG1 1 
ATOM   896  C  CG2 . VAL A 1 137 ? -13.040 11.450  15.196  1.00 13.12 ? 142 VAL A CG2 1 
ATOM   897  N  N   . ASP A 1 138 ? -15.703 13.230  11.601  1.00 12.90 ? 143 ASP A N   1 
ATOM   898  C  CA  . ASP A 1 138 ? -16.699 13.986  10.889  1.00 13.13 ? 143 ASP A CA  1 
ATOM   899  C  C   . ASP A 1 138 ? -16.857 13.421  9.457   1.00 13.57 ? 143 ASP A C   1 
ATOM   900  O  O   . ASP A 1 138 ? -15.873 12.992  8.819   1.00 12.74 ? 143 ASP A O   1 
ATOM   901  C  CB  . ASP A 1 138 ? -16.244 15.468  10.893  1.00 13.07 ? 143 ASP A CB  1 
ATOM   902  C  CG  . ASP A 1 138 ? -17.386 16.469  10.696  1.00 15.74 ? 143 ASP A CG  1 
ATOM   903  O  OD1 . ASP A 1 138 ? -18.297 16.211  9.908   1.00 15.02 ? 143 ASP A OD1 1 
ATOM   904  O  OD2 . ASP A 1 138 ? -17.332 17.549  11.314  1.00 14.76 ? 143 ASP A OD2 1 
ATOM   905  N  N   . ALA A 1 139 ? -18.093 13.442  8.940   1.00 12.35 ? 144 ALA A N   1 
ATOM   906  C  CA  . ALA A 1 139 ? -18.346 13.251  7.518   1.00 13.82 ? 144 ALA A CA  1 
ATOM   907  C  C   . ALA A 1 139 ? -17.724 14.394  6.715   1.00 15.01 ? 144 ALA A C   1 
ATOM   908  O  O   . ALA A 1 139 ? -17.482 14.232  5.524   1.00 15.67 ? 144 ALA A O   1 
ATOM   909  C  CB  . ALA A 1 139 ? -19.880 13.205  7.236   1.00 13.13 ? 144 ALA A CB  1 
ATOM   910  N  N   . HIS A 1 140 ? -17.527 15.550  7.370   1.00 15.46 ? 145 HIS A N   1 
ATOM   911  C  CA  . HIS A 1 140 ? -17.112 16.814  6.695   1.00 17.20 ? 145 HIS A CA  1 
ATOM   912  C  C   . HIS A 1 140 ? -15.798 17.374  7.207   1.00 17.10 ? 145 HIS A C   1 
ATOM   913  O  O   . HIS A 1 140 ? -15.463 17.143  8.356   1.00 17.51 ? 145 HIS A O   1 
ATOM   914  C  CB  . HIS A 1 140 ? -18.190 17.872  6.908   1.00 16.91 ? 145 HIS A CB  1 
ATOM   915  C  CG  . HIS A 1 140 ? -19.559 17.374  6.590   1.00 16.39 ? 145 HIS A CG  1 
ATOM   916  N  ND1 . HIS A 1 140 ? -20.441 16.937  7.558   1.00 17.44 ? 145 HIS A ND1 1 
ATOM   917  C  CD2 . HIS A 1 140 ? -20.176 17.180  5.404   1.00 17.34 ? 145 HIS A CD2 1 
ATOM   918  C  CE1 . HIS A 1 140 ? -21.558 16.525  6.978   1.00 16.35 ? 145 HIS A CE1 1 
ATOM   919  N  NE2 . HIS A 1 140 ? -21.433 16.679  5.673   1.00 16.77 ? 145 HIS A NE2 1 
ATOM   920  N  N   . ALA A 1 141 ? -15.055 18.082  6.342   1.00 17.66 ? 146 ALA A N   1 
ATOM   921  C  CA  . ALA A 1 141 ? -13.750 18.650  6.726   1.00 19.14 ? 146 ALA A CA  1 
ATOM   922  C  C   . ALA A 1 141 ? -13.939 20.018  7.390   1.00 18.67 ? 146 ALA A C   1 
ATOM   923  O  O   . ALA A 1 141 ? -13.065 20.482  8.111   1.00 18.70 ? 146 ALA A O   1 
ATOM   924  C  CB  . ALA A 1 141 ? -12.828 18.772  5.529   1.00 18.42 ? 146 ALA A CB  1 
ATOM   925  N  N   . ASP A 1 142 ? -15.098 20.628  7.141   1.00 20.01 ? 147 ASP A N   1 
ATOM   926  C  CA  . ASP A 1 142 ? -15.471 21.909  7.765   1.00 20.94 ? 147 ASP A CA  1 
ATOM   927  C  C   . ASP A 1 142 ? -14.346 22.940  7.638   1.00 21.47 ? 147 ASP A C   1 
ATOM   928  O  O   . ASP A 1 142 ? -14.075 23.665  8.592   1.00 21.92 ? 147 ASP A O   1 
ATOM   929  C  CB  . ASP A 1 142 ? -15.807 21.682  9.250   1.00 20.41 ? 147 ASP A CB  1 
ATOM   930  C  CG  . ASP A 1 142 ? -17.123 20.948  9.440   1.00 19.79 ? 147 ASP A CG  1 
ATOM   931  O  OD1 . ASP A 1 142 ? -17.888 20.820  8.460   1.00 20.41 ? 147 ASP A OD1 1 
ATOM   932  O  OD2 . ASP A 1 142 ? -17.400 20.504  10.576  1.00 19.75 ? 147 ASP A OD2 1 
ATOM   933  N  N   . ILE A 1 143 ? -13.687 22.984  6.475   1.00 21.87 ? 148 ILE A N   1 
ATOM   934  C  CA  . ILE A 1 143 ? -12.444 23.771  6.290   1.00 22.94 ? 148 ILE A CA  1 
ATOM   935  C  C   . ILE A 1 143 ? -12.578 24.794  5.159   1.00 24.17 ? 148 ILE A C   1 
ATOM   936  O  O   . ILE A 1 143 ? -11.574 25.343  4.679   1.00 23.28 ? 148 ILE A O   1 
ATOM   937  C  CB  . ILE A 1 143 ? -11.205 22.889  6.043   1.00 23.51 ? 148 ILE A CB  1 
ATOM   938  C  CG1 . ILE A 1 143 ? -9.891  23.702  6.175   1.00 23.56 ? 148 ILE A CG1 1 
ATOM   939  C  CG2 . ILE A 1 143 ? -11.316 22.151  4.681   1.00 23.62 ? 148 ILE A CG2 1 
ATOM   940  C  CD1 . ILE A 1 143 ? -8.608  22.846  6.480   1.00 23.21 ? 148 ILE A CD1 1 
ATOM   941  N  N   . ASN A 1 144 ? -13.817 25.053  4.748   1.00 23.80 ? 149 ASN A N   1 
ATOM   942  C  CA  . ASN A 1 144 ? -14.104 26.149  3.832   1.00 25.68 ? 149 ASN A CA  1 
ATOM   943  C  C   . ASN A 1 144 ? -13.667 27.461  4.481   1.00 26.41 ? 149 ASN A C   1 
ATOM   944  O  O   . ASN A 1 144 ? -13.711 27.597  5.710   1.00 25.28 ? 149 ASN A O   1 
ATOM   945  C  CB  . ASN A 1 144 ? -15.605 26.183  3.480   1.00 25.48 ? 149 ASN A CB  1 
ATOM   946  C  CG  . ASN A 1 144 ? -15.943 25.337  2.252   1.00 26.19 ? 149 ASN A CG  1 
ATOM   947  O  OD1 . ASN A 1 144 ? -15.331 25.497  1.198   1.00 26.92 ? 149 ASN A OD1 1 
ATOM   948  N  ND2 . ASN A 1 144 ? -16.932 24.444  2.380   1.00 24.79 ? 149 ASN A ND2 1 
ATOM   949  N  N   . THR A 1 145 ? -13.169 28.401  3.679   1.00 27.45 ? 150 THR A N   1 
ATOM   950  C  CA  . THR A 1 145 ? -12.938 29.734  4.211   1.00 27.60 ? 150 THR A CA  1 
ATOM   951  C  C   . THR A 1 145 ? -14.214 30.580  4.065   1.00 28.48 ? 150 THR A C   1 
ATOM   952  O  O   . THR A 1 145 ? -15.201 30.146  3.453   1.00 28.33 ? 150 THR A O   1 
ATOM   953  C  CB  . THR A 1 145 ? -11.745 30.444  3.543   1.00 27.73 ? 150 THR A CB  1 
ATOM   954  O  OG1 . THR A 1 145 ? -12.132 30.867  2.241   1.00 26.80 ? 150 THR A OG1 1 
ATOM   955  C  CG2 . THR A 1 145 ? -10.515 29.536  3.459   1.00 27.49 ? 150 THR A CG2 1 
ATOM   956  N  N   . PRO A 1 146 ? -14.209 31.802  4.632   1.00 29.34 ? 151 PRO A N   1 
ATOM   957  C  CA  . PRO A 1 146 ? -15.345 32.689  4.352   1.00 29.95 ? 151 PRO A CA  1 
ATOM   958  C  C   . PRO A 1 146 ? -15.457 33.021  2.848   1.00 30.96 ? 151 PRO A C   1 
ATOM   959  O  O   . PRO A 1 146 ? -16.524 33.416  2.367   1.00 31.51 ? 151 PRO A O   1 
ATOM   960  C  CB  . PRO A 1 146 ? -15.017 33.932  5.175   1.00 30.16 ? 151 PRO A CB  1 
ATOM   961  C  CG  . PRO A 1 146 ? -14.062 33.437  6.280   1.00 29.06 ? 151 PRO A CG  1 
ATOM   962  C  CD  . PRO A 1 146 ? -13.268 32.369  5.630   1.00 29.37 ? 151 PRO A CD  1 
ATOM   963  N  N   . LEU A 1 147 ? -14.366 32.823  2.111   1.00 31.52 ? 152 LEU A N   1 
ATOM   964  C  CA  . LEU A 1 147 ? -14.365 33.079  0.670   1.00 32.60 ? 152 LEU A CA  1 
ATOM   965  C  C   . LEU A 1 147 ? -14.743 31.870  -0.190  1.00 33.29 ? 152 LEU A C   1 
ATOM   966  O  O   . LEU A 1 147 ? -15.196 32.061  -1.319  1.00 33.80 ? 152 LEU A O   1 
ATOM   967  C  CB  . LEU A 1 147 ? -13.004 33.645  0.212   1.00 33.07 ? 152 LEU A CB  1 
ATOM   968  C  CG  . LEU A 1 147 ? -12.381 34.816  0.996   1.00 32.07 ? 152 LEU A CG  1 
ATOM   969  C  CD1 . LEU A 1 147 ? -11.000 35.161  0.430   1.00 31.40 ? 152 LEU A CD1 1 
ATOM   970  C  CD2 . LEU A 1 147 ? -13.304 36.056  1.095   1.00 34.68 ? 152 LEU A CD2 1 
ATOM   971  N  N   . THR A 1 148 ? -14.564 30.640  0.323   1.00 32.73 ? 153 THR A N   1 
ATOM   972  C  CA  . THR A 1 148 ? -14.824 29.438  -0.483  1.00 32.25 ? 153 THR A CA  1 
ATOM   973  C  C   . THR A 1 148 ? -16.183 28.822  -0.188  1.00 32.79 ? 153 THR A C   1 
ATOM   974  O  O   . THR A 1 148 ? -16.711 28.049  -0.993  1.00 32.66 ? 153 THR A O   1 
ATOM   975  C  CB  . THR A 1 148 ? -13.725 28.362  -0.321  1.00 32.73 ? 153 THR A CB  1 
ATOM   976  O  OG1 . THR A 1 148 ? -13.792 27.777  0.995   1.00 30.43 ? 153 THR A OG1 1 
ATOM   977  C  CG2 . THR A 1 148 ? -12.326 28.963  -0.585  1.00 32.32 ? 153 THR A CG2 1 
ATOM   978  N  N   . THR A 1 149 ? -16.752 29.165  0.966   1.00 32.66 ? 154 THR A N   1 
ATOM   979  C  CA  . THR A 1 149 ? -18.053 28.636  1.361   1.00 32.71 ? 154 THR A CA  1 
ATOM   980  C  C   . THR A 1 149 ? -19.192 28.999  0.394   1.00 33.52 ? 154 THR A C   1 
ATOM   981  O  O   . THR A 1 149 ? -19.264 30.134  -0.091  1.00 33.59 ? 154 THR A O   1 
ATOM   982  C  CB  . THR A 1 149 ? -18.451 29.095  2.775   1.00 32.06 ? 154 THR A CB  1 
ATOM   983  O  OG1 . THR A 1 149 ? -19.798 28.690  3.018   1.00 28.78 ? 154 THR A OG1 1 
ATOM   984  C  CG2 . THR A 1 149 ? -18.363 30.612  2.906   1.00 33.06 ? 154 THR A CG2 1 
ATOM   985  N  N   . SER A 1 150 ? -20.069 28.022  0.141   1.00 34.05 ? 155 SER A N   1 
ATOM   986  C  CA  . SER A 1 150 ? -21.246 28.172  -0.741  1.00 34.68 ? 155 SER A CA  1 
ATOM   987  C  C   . SER A 1 150 ? -22.535 28.383  0.042   1.00 34.89 ? 155 SER A C   1 
ATOM   988  O  O   . SER A 1 150 ? -23.534 28.895  -0.494  1.00 34.58 ? 155 SER A O   1 
ATOM   989  C  CB  . SER A 1 150 ? -21.426 26.926  -1.610  1.00 34.87 ? 155 SER A CB  1 
ATOM   990  O  OG  . SER A 1 150 ? -20.204 26.555  -2.236  1.00 37.29 ? 155 SER A OG  1 
ATOM   991  N  N   . SER A 1 151 ? -22.533 27.944  1.301   1.00 34.10 ? 156 SER A N   1 
ATOM   992  C  CA  . SER A 1 151 ? -23.735 27.985  2.119   1.00 33.41 ? 156 SER A CA  1 
ATOM   993  C  C   . SER A 1 151 ? -23.763 29.242  2.997   1.00 33.05 ? 156 SER A C   1 
ATOM   994  O  O   . SER A 1 151 ? -24.837 29.721  3.353   1.00 33.93 ? 156 SER A O   1 
ATOM   995  C  CB  . SER A 1 151 ? -23.799 26.743  3.005   1.00 33.68 ? 156 SER A CB  1 
ATOM   996  O  OG  . SER A 1 151 ? -22.734 26.752  3.943   1.00 32.50 ? 156 SER A OG  1 
ATOM   997  N  N   . GLY A 1 152 ? -22.580 29.753  3.345   1.00 32.47 ? 157 GLY A N   1 
ATOM   998  C  CA  . GLY A 1 152 ? -22.424 30.863  4.309   1.00 31.77 ? 157 GLY A CA  1 
ATOM   999  C  C   . GLY A 1 152 ? -22.457 30.397  5.768   1.00 31.38 ? 157 GLY A C   1 
ATOM   1000 O  O   . GLY A 1 152 ? -22.248 31.204  6.694   1.00 31.74 ? 157 GLY A O   1 
ATOM   1001 N  N   . ASN A 1 153 ? -22.715 29.099  5.976   1.00 30.00 ? 158 ASN A N   1 
ATOM   1002 C  CA  . ASN A 1 153 ? -22.821 28.520  7.325   1.00 28.66 ? 158 ASN A CA  1 
ATOM   1003 C  C   . ASN A 1 153 ? -21.452 28.343  7.963   1.00 27.53 ? 158 ASN A C   1 
ATOM   1004 O  O   . ASN A 1 153 ? -20.589 27.628  7.427   1.00 27.11 ? 158 ASN A O   1 
ATOM   1005 C  CB  . ASN A 1 153 ? -23.562 27.203  7.271   1.00 29.06 ? 158 ASN A CB  1 
ATOM   1006 C  CG  . ASN A 1 153 ? -24.990 27.368  6.763   1.00 30.83 ? 158 ASN A CG  1 
ATOM   1007 O  OD1 . ASN A 1 153 ? -25.588 28.434  6.906   1.00 32.16 ? 158 ASN A OD1 1 
ATOM   1008 N  ND2 . ASN A 1 153 ? -25.523 26.328  6.144   1.00 29.66 ? 158 ASN A ND2 1 
ATOM   1009 N  N   . LEU A 1 154 ? -21.249 29.009  9.099   1.00 25.66 ? 159 LEU A N   1 
ATOM   1010 C  CA  . LEU A 1 154 ? -19.952 28.973  9.789   1.00 24.55 ? 159 LEU A CA  1 
ATOM   1011 C  C   . LEU A 1 154 ? -19.541 27.597  10.332  1.00 23.36 ? 159 LEU A C   1 
ATOM   1012 O  O   . LEU A 1 154 ? -18.353 27.352  10.549  1.00 23.39 ? 159 LEU A O   1 
ATOM   1013 C  CB  . LEU A 1 154 ? -19.888 30.039  10.897  1.00 24.42 ? 159 LEU A CB  1 
ATOM   1014 C  CG  . LEU A 1 154 ? -19.592 31.437  10.326  1.00 24.93 ? 159 LEU A CG  1 
ATOM   1015 C  CD1 . LEU A 1 154 ? -19.999 32.517  11.311  1.00 25.70 ? 159 LEU A CD1 1 
ATOM   1016 C  CD2 . LEU A 1 154 ? -18.152 31.608  9.956   1.00 23.58 ? 159 LEU A CD2 1 
ATOM   1017 N  N   . HIS A 1 155 ? -20.495 26.700  10.526  1.00 23.38 ? 160 HIS A N   1 
ATOM   1018 C  CA  . HIS A 1 155 ? -20.155 25.336  10.996  1.00 23.04 ? 160 HIS A CA  1 
ATOM   1019 C  C   . HIS A 1 155 ? -19.441 24.512  9.901   1.00 22.89 ? 160 HIS A C   1 
ATOM   1020 O  O   . HIS A 1 155 ? -18.958 23.422  10.170  1.00 22.26 ? 160 HIS A O   1 
ATOM   1021 C  CB  . HIS A 1 155 ? -21.401 24.617  11.546  1.00 22.62 ? 160 HIS A CB  1 
ATOM   1022 C  CG  . HIS A 1 155 ? -22.294 24.037  10.485  1.00 22.99 ? 160 HIS A CG  1 
ATOM   1023 N  ND1 . HIS A 1 155 ? -23.125 22.962  10.723  1.00 22.01 ? 160 HIS A ND1 1 
ATOM   1024 C  CD2 . HIS A 1 155 ? -22.476 24.368  9.181   1.00 23.16 ? 160 HIS A CD2 1 
ATOM   1025 C  CE1 . HIS A 1 155 ? -23.788 22.666  9.618   1.00 23.49 ? 160 HIS A CE1 1 
ATOM   1026 N  NE2 . HIS A 1 155 ? -23.412 23.503  8.669   1.00 20.88 ? 160 HIS A NE2 1 
ATOM   1027 N  N   . GLY A 1 156 ? -19.376 25.066  8.675   1.00 22.23 ? 161 GLY A N   1 
ATOM   1028 C  CA  . GLY A 1 156 ? -18.657 24.463  7.551   1.00 21.35 ? 161 GLY A CA  1 
ATOM   1029 C  C   . GLY A 1 156 ? -17.300 25.144  7.354   1.00 20.74 ? 161 GLY A C   1 
ATOM   1030 O  O   . GLY A 1 156 ? -16.576 24.819  6.427   1.00 20.71 ? 161 GLY A O   1 
ATOM   1031 N  N   . GLN A 1 157 ? -16.971 26.078  8.246   1.00 20.73 ? 162 GLN A N   1 
ATOM   1032 C  CA  . GLN A 1 157 ? -15.744 26.894  8.181   1.00 20.74 ? 162 GLN A CA  1 
ATOM   1033 C  C   . GLN A 1 157 ? -14.783 26.877  9.385   1.00 20.78 ? 162 GLN A C   1 
ATOM   1034 O  O   . GLN A 1 157 ? -13.696 27.474  9.297   1.00 20.43 ? 162 GLN A O   1 
ATOM   1035 C  CB  . GLN A 1 157 ? -16.124 28.356  7.926   1.00 21.85 ? 162 GLN A CB  1 
ATOM   1036 C  CG  . GLN A 1 157 ? -16.927 28.557  6.663   1.00 21.46 ? 162 GLN A CG  1 
ATOM   1037 C  CD  . GLN A 1 157 ? -17.420 29.981  6.536   1.00 24.41 ? 162 GLN A CD  1 
ATOM   1038 O  OE1 . GLN A 1 157 ? -16.628 30.922  6.553   1.00 25.79 ? 162 GLN A OE1 1 
ATOM   1039 N  NE2 . GLN A 1 157 ? -18.732 30.143  6.424   1.00 22.06 ? 162 GLN A NE2 1 
ATOM   1040 N  N   . PRO A 1 158 ? -15.138 26.171  10.492  1.00 20.72 ? 163 PRO A N   1 
ATOM   1041 C  CA  . PRO A 1 158 ? -14.356 26.431  11.699  1.00 20.89 ? 163 PRO A CA  1 
ATOM   1042 C  C   . PRO A 1 158 ? -12.863 26.192  11.559  1.00 21.40 ? 163 PRO A C   1 
ATOM   1043 O  O   . PRO A 1 158 ? -12.071 26.958  12.123  1.00 21.69 ? 163 PRO A O   1 
ATOM   1044 C  CB  . PRO A 1 158 ? -14.985 25.479  12.746  1.00 21.62 ? 163 PRO A CB  1 
ATOM   1045 C  CG  . PRO A 1 158 ? -15.622 24.372  11.944  1.00 19.62 ? 163 PRO A CG  1 
ATOM   1046 C  CD  . PRO A 1 158 ? -16.137 25.112  10.717  1.00 20.09 ? 163 PRO A CD  1 
ATOM   1047 N  N   . VAL A 1 159 ? -12.457 25.161  10.819  1.00 21.53 ? 164 VAL A N   1 
ATOM   1048 C  CA  . VAL A 1 159 ? -11.029 24.808  10.754  1.00 21.78 ? 164 VAL A CA  1 
ATOM   1049 C  C   . VAL A 1 159 ? -10.192 25.925  10.066  1.00 22.85 ? 164 VAL A C   1 
ATOM   1050 O  O   . VAL A 1 159 ? -9.029  26.151  10.417  1.00 24.05 ? 164 VAL A O   1 
ATOM   1051 C  CB  . VAL A 1 159 ? -10.768 23.402  10.100  1.00 21.46 ? 164 VAL A CB  1 
ATOM   1052 C  CG1 . VAL A 1 159 ? -9.256  23.113  10.028  1.00 21.15 ? 164 VAL A CG1 1 
ATOM   1053 C  CG2 . VAL A 1 159 ? -11.438 22.296  10.879  1.00 21.67 ? 164 VAL A CG2 1 
ATOM   1054 N  N   . SER A 1 160 ? -10.802 26.643  9.128   1.00 23.40 ? 165 SER A N   1 
ATOM   1055 C  CA  . SER A 1 160 ? -10.094 27.725  8.432   1.00 24.83 ? 165 SER A CA  1 
ATOM   1056 C  C   . SER A 1 160 ? -9.627  28.862  9.364   1.00 25.62 ? 165 SER A C   1 
ATOM   1057 O  O   . SER A 1 160 ? -8.596  29.479  9.098   1.00 25.45 ? 165 SER A O   1 
ATOM   1058 C  CB  . SER A 1 160 ? -10.929 28.279  7.274   1.00 24.34 ? 165 SER A CB  1 
ATOM   1059 O  OG  . SER A 1 160 ? -12.000 29.094  7.736   1.00 27.02 ? 165 SER A OG  1 
ATOM   1060 N  N   . PHE A 1 161 ? -10.359 29.107  10.460  1.00 25.88 ? 166 PHE A N   1 
ATOM   1061 C  CA  . PHE A 1 161 ? -9.989  30.153  11.419  1.00 26.72 ? 166 PHE A CA  1 
ATOM   1062 C  C   . PHE A 1 161 ? -8.847  29.714  12.330  1.00 27.17 ? 166 PHE A C   1 
ATOM   1063 O  O   . PHE A 1 161 ? -8.113  30.538  12.884  1.00 27.24 ? 166 PHE A O   1 
ATOM   1064 C  CB  . PHE A 1 161 ? -11.211 30.577  12.241  1.00 26.77 ? 166 PHE A CB  1 
ATOM   1065 C  CG  . PHE A 1 161 ? -12.346 31.088  11.401  1.00 28.29 ? 166 PHE A CG  1 
ATOM   1066 C  CD1 . PHE A 1 161 ? -13.505 30.333  11.223  1.00 28.25 ? 166 PHE A CD1 1 
ATOM   1067 C  CD2 . PHE A 1 161 ? -12.249 32.330  10.766  1.00 29.02 ? 166 PHE A CD2 1 
ATOM   1068 C  CE1 . PHE A 1 161 ? -14.551 30.795  10.426  1.00 28.50 ? 166 PHE A CE1 1 
ATOM   1069 C  CE2 . PHE A 1 161 ? -13.282 32.803  9.963   1.00 29.41 ? 166 PHE A CE2 1 
ATOM   1070 C  CZ  . PHE A 1 161 ? -14.444 32.036  9.792   1.00 28.95 ? 166 PHE A CZ  1 
ATOM   1071 N  N   . LEU A 1 162 ? -8.686  28.403  12.460  1.00 26.06 ? 167 LEU A N   1 
ATOM   1072 C  CA  . LEU A 1 162 ? -7.826  27.856  13.481  1.00 26.24 ? 167 LEU A CA  1 
ATOM   1073 C  C   . LEU A 1 162 ? -6.439  27.574  12.964  1.00 26.38 ? 167 LEU A C   1 
ATOM   1074 O  O   . LEU A 1 162 ? -5.507  27.552  13.732  1.00 26.58 ? 167 LEU A O   1 
ATOM   1075 C  CB  . LEU A 1 162 ? -8.458  26.579  14.058  1.00 25.43 ? 167 LEU A CB  1 
ATOM   1076 C  CG  . LEU A 1 162 ? -9.786  26.733  14.796  1.00 26.26 ? 167 LEU A CG  1 
ATOM   1077 C  CD1 . LEU A 1 162 ? -10.360 25.374  15.124  1.00 24.02 ? 167 LEU A CD1 1 
ATOM   1078 C  CD2 . LEU A 1 162 ? -9.618  27.554  16.092  1.00 26.78 ? 167 LEU A CD2 1 
ATOM   1079 N  N   . LEU A 1 163 ? -6.322  27.373  11.651  1.00 27.41 ? 168 LEU A N   1 
ATOM   1080 C  CA  . LEU A 1 163 ? -5.122  26.832  11.012  1.00 29.10 ? 168 LEU A CA  1 
ATOM   1081 C  C   . LEU A 1 163 ? -4.124  27.925  10.623  1.00 29.92 ? 168 LEU A C   1 
ATOM   1082 O  O   . LEU A 1 163 ? -4.441  28.809  9.833   1.00 30.85 ? 168 LEU A O   1 
ATOM   1083 C  CB  . LEU A 1 163 ? -5.536  26.042  9.762   1.00 29.04 ? 168 LEU A CB  1 
ATOM   1084 C  CG  . LEU A 1 163 ? -4.602  24.968  9.223   1.00 31.61 ? 168 LEU A CG  1 
ATOM   1085 C  CD1 . LEU A 1 163 ? -4.610  23.717  10.114  1.00 33.09 ? 168 LEU A CD1 1 
ATOM   1086 C  CD2 . LEU A 1 163 ? -5.036  24.631  7.815   1.00 33.37 ? 168 LEU A CD2 1 
ATOM   1087 N  N   . ARG A 1 164 ? -2.922  27.857  11.184  1.00 31.72 ? 169 ARG A N   1 
ATOM   1088 C  CA  . ARG A 1 164 ? -1.879  28.858  10.920  1.00 33.37 ? 169 ARG A CA  1 
ATOM   1089 C  C   . ARG A 1 164 ? -1.689  29.098  9.421   1.00 33.65 ? 169 ARG A C   1 
ATOM   1090 O  O   . ARG A 1 164 ? -1.832  30.226  8.950   1.00 33.84 ? 169 ARG A O   1 
ATOM   1091 C  CB  . ARG A 1 164 ? -0.546  28.445  11.568  1.00 33.44 ? 169 ARG A CB  1 
ATOM   1092 C  CG  . ARG A 1 164 ? -0.495  28.727  13.069  1.00 36.44 ? 169 ARG A CG  1 
ATOM   1093 C  CD  . ARG A 1 164 ? 0.937   28.774  13.587  1.00 41.33 ? 169 ARG A CD  1 
ATOM   1094 N  NE  . ARG A 1 164 ? 1.286   27.534  14.266  1.00 45.43 ? 169 ARG A NE  1 
ATOM   1095 C  CZ  . ARG A 1 164 ? 0.912   27.235  15.508  1.00 46.79 ? 169 ARG A CZ  1 
ATOM   1096 N  NH1 . ARG A 1 164 ? 0.183   28.090  16.211  1.00 48.11 ? 169 ARG A NH1 1 
ATOM   1097 N  NH2 . ARG A 1 164 ? 1.264   26.076  16.045  1.00 47.61 ? 169 ARG A NH2 1 
ATOM   1098 N  N   . GLU A 1 165 ? -1.406  28.015  8.688   1.00 34.36 ? 170 GLU A N   1 
ATOM   1099 C  CA  . GLU A 1 165 ? -1.019  28.062  7.272   1.00 34.15 ? 170 GLU A CA  1 
ATOM   1100 C  C   . GLU A 1 165 ? -2.059  28.688  6.348   1.00 34.59 ? 170 GLU A C   1 
ATOM   1101 O  O   . GLU A 1 165 ? -1.753  28.985  5.188   1.00 35.23 ? 170 GLU A O   1 
ATOM   1102 C  CB  . GLU A 1 165 ? -0.650  26.660  6.761   1.00 34.42 ? 170 GLU A CB  1 
ATOM   1103 C  CG  . GLU A 1 165 ? 0.694   26.109  7.274   1.00 34.24 ? 170 GLU A CG  1 
ATOM   1104 C  CD  . GLU A 1 165 ? 0.591   25.412  8.642   1.00 34.71 ? 170 GLU A CD  1 
ATOM   1105 O  OE1 . GLU A 1 165 ? -0.512  25.385  9.231   1.00 32.67 ? 170 GLU A OE1 1 
ATOM   1106 O  OE2 . GLU A 1 165 ? 1.615   24.889  9.136   1.00 36.15 ? 170 GLU A OE2 1 
ATOM   1107 N  N   . LEU A 1 166 ? -3.279  28.879  6.845   1.00 34.29 ? 171 LEU A N   1 
ATOM   1108 C  CA  . LEU A 1 166 ? -4.371  29.412  6.025   1.00 34.80 ? 171 LEU A CA  1 
ATOM   1109 C  C   . LEU A 1 166 ? -4.722  30.870  6.349   1.00 35.27 ? 171 LEU A C   1 
ATOM   1110 O  O   . LEU A 1 166 ? -5.677  31.422  5.780   1.00 35.11 ? 171 LEU A O   1 
ATOM   1111 C  CB  . LEU A 1 166 ? -5.606  28.523  6.216   1.00 34.67 ? 171 LEU A CB  1 
ATOM   1112 C  CG  . LEU A 1 166 ? -6.609  28.073  5.150   1.00 34.46 ? 171 LEU A CG  1 
ATOM   1113 C  CD1 . LEU A 1 166 ? -5.984  27.519  3.884   1.00 31.70 ? 171 LEU A CD1 1 
ATOM   1114 C  CD2 . LEU A 1 166 ? -7.503  27.008  5.781   1.00 33.06 ? 171 LEU A CD2 1 
ATOM   1115 N  N   . GLN A 1 167 ? -3.966  31.490  7.258   1.00 35.69 ? 172 GLN A N   1 
ATOM   1116 C  CA  . GLN A 1 167 ? -4.333  32.815  7.789   1.00 36.88 ? 172 GLN A CA  1 
ATOM   1117 C  C   . GLN A 1 167 ? -4.490  33.894  6.716   1.00 37.02 ? 172 GLN A C   1 
ATOM   1118 O  O   . GLN A 1 167 ? -5.425  34.706  6.771   1.00 36.94 ? 172 GLN A O   1 
ATOM   1119 C  CB  . GLN A 1 167 ? -3.347  33.299  8.869   1.00 37.00 ? 172 GLN A CB  1 
ATOM   1120 C  CG  . GLN A 1 167 ? -3.627  34.764  9.292   1.00 38.79 ? 172 GLN A CG  1 
ATOM   1121 C  CD  . GLN A 1 167 ? -3.157  35.103  10.680  1.00 41.16 ? 172 GLN A CD  1 
ATOM   1122 O  OE1 . GLN A 1 167 ? -1.993  34.894  11.024  1.00 41.34 ? 172 GLN A OE1 1 
ATOM   1123 N  NE2 . GLN A 1 167 ? -4.064  35.648  11.497  1.00 41.67 ? 172 GLN A NE2 1 
ATOM   1124 N  N   . ASP A 1 168 ? -3.593  33.887  5.733   1.00 37.56 ? 173 ASP A N   1 
ATOM   1125 C  CA  . ASP A 1 168 ? -3.619  34.904  4.677   1.00 38.29 ? 173 ASP A CA  1 
ATOM   1126 C  C   . ASP A 1 168 ? -4.716  34.671  3.631   1.00 38.04 ? 173 ASP A C   1 
ATOM   1127 O  O   . ASP A 1 168 ? -4.996  35.542  2.796   1.00 37.93 ? 173 ASP A O   1 
ATOM   1128 C  CB  . ASP A 1 168 ? -2.233  35.033  4.026   1.00 38.76 ? 173 ASP A CB  1 
ATOM   1129 C  CG  . ASP A 1 168 ? -1.796  33.771  3.300   1.00 41.46 ? 173 ASP A CG  1 
ATOM   1130 O  OD1 . ASP A 1 168 ? -2.592  32.798  3.177   1.00 42.97 ? 173 ASP A OD1 1 
ATOM   1131 O  OD2 . ASP A 1 168 ? -0.632  33.761  2.847   1.00 43.61 ? 173 ASP A OD2 1 
ATOM   1132 N  N   . LYS A 1 169 ? -5.330  33.487  3.676   1.00 37.39 ? 174 LYS A N   1 
ATOM   1133 C  CA  . LYS A 1 169 ? -6.460  33.164  2.813   1.00 36.89 ? 174 LYS A CA  1 
ATOM   1134 C  C   . LYS A 1 169 ? -7.778  33.499  3.496   1.00 36.70 ? 174 LYS A C   1 
ATOM   1135 O  O   . LYS A 1 169 ? -8.848  33.405  2.879   1.00 36.84 ? 174 LYS A O   1 
ATOM   1136 C  CB  . LYS A 1 169 ? -6.461  31.677  2.422   1.00 37.14 ? 174 LYS A CB  1 
ATOM   1137 C  CG  . LYS A 1 169 ? -5.165  31.136  1.854   1.00 37.94 ? 174 LYS A CG  1 
ATOM   1138 C  CD  . LYS A 1 169 ? -4.863  31.710  0.481   1.00 40.50 ? 174 LYS A CD  1 
ATOM   1139 C  CE  . LYS A 1 169 ? -3.464  31.304  0.064   1.00 40.44 ? 174 LYS A CE  1 
ATOM   1140 N  NZ  . LYS A 1 169 ? -2.774  32.378  -0.677  1.00 42.72 ? 174 LYS A NZ  1 
ATOM   1141 N  N   . VAL A 1 170 ? -7.699  33.875  4.773   1.00 36.44 ? 175 VAL A N   1 
ATOM   1142 C  CA  . VAL A 1 170 ? -8.880  34.102  5.599   1.00 35.82 ? 175 VAL A CA  1 
ATOM   1143 C  C   . VAL A 1 170 ? -9.020  35.591  5.916   1.00 36.61 ? 175 VAL A C   1 
ATOM   1144 O  O   . VAL A 1 170 ? -8.102  36.177  6.518   1.00 35.96 ? 175 VAL A O   1 
ATOM   1145 C  CB  . VAL A 1 170 ? -8.798  33.296  6.938   1.00 35.86 ? 175 VAL A CB  1 
ATOM   1146 C  CG1 . VAL A 1 170 ? -10.036 33.536  7.816   1.00 34.48 ? 175 VAL A CG1 1 
ATOM   1147 C  CG2 . VAL A 1 170 ? -8.608  31.794  6.660   1.00 35.30 ? 175 VAL A CG2 1 
ATOM   1148 N  N   . PRO A 1 171 ? -10.156 36.204  5.507   1.00 36.65 ? 176 PRO A N   1 
ATOM   1149 C  CA  . PRO A 1 171 ? -10.443 37.606  5.826   1.00 37.50 ? 176 PRO A CA  1 
ATOM   1150 C  C   . PRO A 1 171 ? -10.877 37.758  7.281   1.00 38.31 ? 176 PRO A C   1 
ATOM   1151 O  O   . PRO A 1 171 ? -11.320 36.789  7.901   1.00 38.07 ? 176 PRO A O   1 
ATOM   1152 C  CB  . PRO A 1 171 ? -11.623 37.943  4.903   1.00 37.11 ? 176 PRO A CB  1 
ATOM   1153 C  CG  . PRO A 1 171 ? -12.303 36.652  4.687   1.00 36.63 ? 176 PRO A CG  1 
ATOM   1154 C  CD  . PRO A 1 171 ? -11.215 35.612  4.672   1.00 36.27 ? 176 PRO A CD  1 
ATOM   1155 N  N   . GLN A 1 172 ? -10.764 38.973  7.804   1.00 39.08 ? 177 GLN A N   1 
ATOM   1156 C  CA  . GLN A 1 172 ? -11.191 39.262  9.159   1.00 39.86 ? 177 GLN A CA  1 
ATOM   1157 C  C   . GLN A 1 172 ? -12.706 39.432  9.143   1.00 39.55 ? 177 GLN A C   1 
ATOM   1158 O  O   . GLN A 1 172 ? -13.215 40.295  8.438   1.00 40.30 ? 177 GLN A O   1 
ATOM   1159 C  CB  . GLN A 1 172 ? -10.507 40.530  9.662   1.00 40.25 ? 177 GLN A CB  1 
ATOM   1160 C  CG  . GLN A 1 172 ? -10.464 40.641  11.187  1.00 43.74 ? 177 GLN A CG  1 
ATOM   1161 C  CD  . GLN A 1 172 ? -10.465 42.085  11.665  1.00 48.14 ? 177 GLN A CD  1 
ATOM   1162 O  OE1 . GLN A 1 172 ? -9.681  42.912  11.185  1.00 49.99 ? 177 GLN A OE1 1 
ATOM   1163 N  NE2 . GLN A 1 172 ? -11.355 42.398  12.607  1.00 48.26 ? 177 GLN A NE2 1 
ATOM   1164 N  N   . LEU A 1 173 ? -13.427 38.590  9.881   1.00 38.88 ? 178 LEU A N   1 
ATOM   1165 C  CA  . LEU A 1 173 ? -14.882 38.750  10.027  1.00 38.49 ? 178 LEU A CA  1 
ATOM   1166 C  C   . LEU A 1 173 ? -15.248 39.583  11.270  1.00 38.12 ? 178 LEU A C   1 
ATOM   1167 O  O   . LEU A 1 173 ? -14.477 39.641  12.234  1.00 37.49 ? 178 LEU A O   1 
ATOM   1168 C  CB  . LEU A 1 173 ? -15.586 37.382  10.090  1.00 38.91 ? 178 LEU A CB  1 
ATOM   1169 C  CG  . LEU A 1 173 ? -16.114 36.697  8.808   1.00 39.71 ? 178 LEU A CG  1 
ATOM   1170 C  CD1 . LEU A 1 173 ? -15.095 36.707  7.689   1.00 40.05 ? 178 LEU A CD1 1 
ATOM   1171 C  CD2 . LEU A 1 173 ? -16.590 35.257  9.090   1.00 39.71 ? 178 LEU A CD2 1 
ATOM   1172 N  N   . PRO A 1 174 ? -16.434 40.220  11.250  1.00 38.04 ? 179 PRO A N   1 
ATOM   1173 C  CA  . PRO A 1 174 ? -16.992 40.883  12.424  1.00 37.77 ? 179 PRO A CA  1 
ATOM   1174 C  C   . PRO A 1 174 ? -17.302 39.857  13.518  1.00 37.45 ? 179 PRO A C   1 
ATOM   1175 O  O   . PRO A 1 174 ? -17.977 38.853  13.264  1.00 37.04 ? 179 PRO A O   1 
ATOM   1176 C  CB  . PRO A 1 174 ? -18.294 41.482  11.888  1.00 37.65 ? 179 PRO A CB  1 
ATOM   1177 C  CG  . PRO A 1 174 ? -18.647 40.616  10.730  1.00 38.27 ? 179 PRO A CG  1 
ATOM   1178 C  CD  . PRO A 1 174 ? -17.339 40.338  10.092  1.00 38.05 ? 179 PRO A CD  1 
ATOM   1179 N  N   . GLY A 1 175 ? -16.818 40.124  14.722  1.00 37.05 ? 180 GLY A N   1 
ATOM   1180 C  CA  . GLY A 1 175 ? -16.893 39.149  15.801  1.00 36.73 ? 180 GLY A CA  1 
ATOM   1181 C  C   . GLY A 1 175 ? -15.699 38.211  15.937  1.00 36.44 ? 180 GLY A C   1 
ATOM   1182 O  O   . GLY A 1 175 ? -15.642 37.454  16.902  1.00 36.22 ? 180 GLY A O   1 
ATOM   1183 N  N   . PHE A 1 176 ? -14.740 38.279  15.008  1.00 36.28 ? 181 PHE A N   1 
ATOM   1184 C  CA  . PHE A 1 176 ? -13.625 37.321  14.933  1.00 36.42 ? 181 PHE A CA  1 
ATOM   1185 C  C   . PHE A 1 176 ? -12.218 37.905  15.129  1.00 36.90 ? 181 PHE A C   1 
ATOM   1186 O  O   . PHE A 1 176 ? -11.237 37.209  14.877  1.00 37.03 ? 181 PHE A O   1 
ATOM   1187 C  CB  . PHE A 1 176 ? -13.622 36.613  13.574  1.00 36.37 ? 181 PHE A CB  1 
ATOM   1188 C  CG  . PHE A 1 176 ? -14.653 35.512  13.426  1.00 35.62 ? 181 PHE A CG  1 
ATOM   1189 C  CD1 . PHE A 1 176 ? -16.005 35.808  13.339  1.00 33.92 ? 181 PHE A CD1 1 
ATOM   1190 C  CD2 . PHE A 1 176 ? -14.246 34.176  13.304  1.00 35.56 ? 181 PHE A CD2 1 
ATOM   1191 C  CE1 . PHE A 1 176 ? -16.964 34.790  13.178  1.00 35.75 ? 181 PHE A CE1 1 
ATOM   1192 C  CE2 . PHE A 1 176 ? -15.187 33.144  13.140  1.00 36.42 ? 181 PHE A CE2 1 
ATOM   1193 C  CZ  . PHE A 1 176 ? -16.555 33.455  13.076  1.00 35.22 ? 181 PHE A CZ  1 
ATOM   1194 N  N   . SER A 1 177 ? -12.096 39.160  15.560  1.00 37.35 ? 182 SER A N   1 
ATOM   1195 C  CA  . SER A 1 177 ? -10.767 39.781  15.701  1.00 37.49 ? 182 SER A CA  1 
ATOM   1196 C  C   . SER A 1 177 ? -9.954  39.154  16.834  1.00 37.88 ? 182 SER A C   1 
ATOM   1197 O  O   . SER A 1 177 ? -8.718  39.223  16.828  1.00 38.05 ? 182 SER A O   1 
ATOM   1198 C  CB  . SER A 1 177 ? -10.874 41.298  15.904  1.00 37.30 ? 182 SER A CB  1 
ATOM   1199 O  OG  . SER A 1 177 ? -11.734 41.598  16.996  1.00 38.11 ? 182 SER A OG  1 
ATOM   1200 N  N   . TRP A 1 178 ? -10.648 38.528  17.786  1.00 37.65 ? 183 TRP A N   1 
ATOM   1201 C  CA  . TRP A 1 178 ? -10.011 37.906  18.953  1.00 37.65 ? 183 TRP A CA  1 
ATOM   1202 C  C   . TRP A 1 178 ? -9.249  36.597  18.661  1.00 38.12 ? 183 TRP A C   1 
ATOM   1203 O  O   . TRP A 1 178 ? -8.380  36.209  19.444  1.00 37.67 ? 183 TRP A O   1 
ATOM   1204 C  CB  . TRP A 1 178 ? -11.047 37.664  20.045  1.00 37.35 ? 183 TRP A CB  1 
ATOM   1205 C  CG  . TRP A 1 178 ? -12.129 36.713  19.616  1.00 36.35 ? 183 TRP A CG  1 
ATOM   1206 C  CD1 . TRP A 1 178 ? -13.299 37.025  18.978  1.00 35.81 ? 183 TRP A CD1 1 
ATOM   1207 C  CD2 . TRP A 1 178 ? -12.125 35.291  19.774  1.00 33.59 ? 183 TRP A CD2 1 
ATOM   1208 N  NE1 . TRP A 1 178 ? -14.025 35.878  18.730  1.00 34.16 ? 183 TRP A NE1 1 
ATOM   1209 C  CE2 . TRP A 1 178 ? -13.334 34.803  19.226  1.00 34.84 ? 183 TRP A CE2 1 
ATOM   1210 C  CE3 . TRP A 1 178 ? -11.227 34.382  20.345  1.00 33.75 ? 183 TRP A CE3 1 
ATOM   1211 C  CZ2 . TRP A 1 178 ? -13.656 33.433  19.209  1.00 33.23 ? 183 TRP A CZ2 1 
ATOM   1212 C  CZ3 . TRP A 1 178 ? -11.551 33.012  20.326  1.00 31.49 ? 183 TRP A CZ3 1 
ATOM   1213 C  CH2 . TRP A 1 178 ? -12.753 32.565  19.770  1.00 32.19 ? 183 TRP A CH2 1 
ATOM   1214 N  N   . ILE A 1 179 ? -9.581  35.923  17.556  1.00 38.48 ? 184 ILE A N   1 
ATOM   1215 C  CA  . ILE A 1 179 ? -9.005  34.608  17.219  1.00 38.81 ? 184 ILE A CA  1 
ATOM   1216 C  C   . ILE A 1 179 ? -7.605  34.663  16.604  1.00 39.25 ? 184 ILE A C   1 
ATOM   1217 O  O   . ILE A 1 179 ? -7.418  35.235  15.530  1.00 40.12 ? 184 ILE A O   1 
ATOM   1218 C  CB  . ILE A 1 179 ? -9.895  33.836  16.208  1.00 38.74 ? 184 ILE A CB  1 
ATOM   1219 C  CG1 . ILE A 1 179 ? -11.361 33.913  16.619  1.00 38.48 ? 184 ILE A CG1 1 
ATOM   1220 C  CG2 . ILE A 1 179 ? -9.413  32.371  16.052  1.00 39.18 ? 184 ILE A CG2 1 
ATOM   1221 C  CD1 . ILE A 1 179 ? -12.324 33.402  15.569  1.00 37.56 ? 184 ILE A CD1 1 
ATOM   1222 N  N   . LYS A 1 180 ? -6.641  34.054  17.290  1.00 39.01 ? 185 LYS A N   1 
ATOM   1223 C  CA  . LYS A 1 180 ? -5.319  33.755  16.736  1.00 39.76 ? 185 LYS A CA  1 
ATOM   1224 C  C   . LYS A 1 180 ? -5.387  32.308  16.210  1.00 38.51 ? 185 LYS A C   1 
ATOM   1225 O  O   . LYS A 1 180 ? -5.867  31.434  16.924  1.00 37.93 ? 185 LYS A O   1 
ATOM   1226 C  CB  . LYS A 1 180 ? -4.234  33.797  17.834  1.00 39.68 ? 185 LYS A CB  1 
ATOM   1227 C  CG  . LYS A 1 180 ? -3.700  35.170  18.265  1.00 43.24 ? 185 LYS A CG  1 
ATOM   1228 C  CD  . LYS A 1 180 ? -2.588  34.989  19.330  1.00 46.25 ? 185 LYS A CD  1 
ATOM   1229 C  CE  . LYS A 1 180 ? -2.480  36.172  20.310  1.00 49.08 ? 185 LYS A CE  1 
ATOM   1230 N  NZ  . LYS A 1 180 ? -3.719  36.409  21.154  1.00 49.30 ? 185 LYS A NZ  1 
ATOM   1231 N  N   . PRO A 1 181 ? -4.911  32.056  14.974  1.00 38.20 ? 186 PRO A N   1 
ATOM   1232 C  CA  . PRO A 1 181 ? -4.783  30.659  14.550  1.00 37.73 ? 186 PRO A CA  1 
ATOM   1233 C  C   . PRO A 1 181 ? -3.826  29.919  15.472  1.00 37.42 ? 186 PRO A C   1 
ATOM   1234 O  O   . PRO A 1 181 ? -2.758  30.446  15.806  1.00 37.10 ? 186 PRO A O   1 
ATOM   1235 C  CB  . PRO A 1 181 ? -4.199  30.747  13.137  1.00 37.80 ? 186 PRO A CB  1 
ATOM   1236 C  CG  . PRO A 1 181 ? -3.911  32.206  12.890  1.00 38.21 ? 186 PRO A CG  1 
ATOM   1237 C  CD  . PRO A 1 181 ? -4.702  32.997  13.859  1.00 38.14 ? 186 PRO A CD  1 
ATOM   1238 N  N   . CYS A 1 182 ? -4.203  28.708  15.877  1.00 36.34 ? 187 CYS A N   1 
ATOM   1239 C  CA  . CYS A 1 182 ? -3.479  28.011  16.947  1.00 36.19 ? 187 CYS A CA  1 
ATOM   1240 C  C   . CYS A 1 182 ? -3.008  26.581  16.644  1.00 36.01 ? 187 CYS A C   1 
ATOM   1241 O  O   . CYS A 1 182 ? -2.383  25.957  17.498  1.00 36.51 ? 187 CYS A O   1 
ATOM   1242 C  CB  . CYS A 1 182 ? -4.344  27.993  18.211  1.00 35.83 ? 187 CYS A CB  1 
ATOM   1243 S  SG  . CYS A 1 182 ? -6.032  27.450  17.891  1.00 35.85 ? 187 CYS A SG  1 
ATOM   1244 N  N   . ILE A 1 183 ? -3.316  26.053  15.460  1.00 34.93 ? 188 ILE A N   1 
ATOM   1245 C  CA  . ILE A 1 183 ? -2.839  24.717  15.085  1.00 34.93 ? 188 ILE A CA  1 
ATOM   1246 C  C   . ILE A 1 183 ? -2.204  24.746  13.704  1.00 33.92 ? 188 ILE A C   1 
ATOM   1247 O  O   . ILE A 1 183 ? -2.699  25.421  12.821  1.00 33.86 ? 188 ILE A O   1 
ATOM   1248 C  CB  . ILE A 1 183 ? -3.965  23.650  15.076  1.00 35.02 ? 188 ILE A CB  1 
ATOM   1249 C  CG1 . ILE A 1 183 ? -5.263  24.236  14.522  1.00 35.44 ? 188 ILE A CG1 1 
ATOM   1250 C  CG2 . ILE A 1 183 ? -4.190  23.078  16.478  1.00 35.90 ? 188 ILE A CG2 1 
ATOM   1251 C  CD1 . ILE A 1 183 ? -6.270  23.181  14.114  1.00 38.99 ? 188 ILE A CD1 1 
ATOM   1252 N  N   . SER A 1 184 ? -1.103  24.022  13.531  1.00 33.36 ? 189 SER A N   1 
ATOM   1253 C  CA  . SER A 1 184 ? -0.508  23.884  12.210  1.00 32.87 ? 189 SER A CA  1 
ATOM   1254 C  C   . SER A 1 184 ? -1.176  22.732  11.476  1.00 32.40 ? 189 SER A C   1 
ATOM   1255 O  O   . SER A 1 184 ? -1.789  21.841  12.088  1.00 31.07 ? 189 SER A O   1 
ATOM   1256 C  CB  . SER A 1 184 ? 1.025   23.731  12.267  1.00 33.13 ? 189 SER A CB  1 
ATOM   1257 O  OG  . SER A 1 184 ? 1.419   22.664  13.129  1.00 36.31 ? 189 SER A OG  1 
ATOM   1258 N  N   . SER A 1 185 ? -1.099  22.786  10.153  1.00 31.37 ? 190 SER A N   1 
ATOM   1259 C  CA  . SER A 1 185 ? -1.740  21.805  9.297   1.00 31.00 ? 190 SER A CA  1 
ATOM   1260 C  C   . SER A 1 185 ? -1.287  20.390  9.653   1.00 29.42 ? 190 SER A C   1 
ATOM   1261 O  O   . SER A 1 185 ? -2.044  19.431  9.468   1.00 28.96 ? 190 SER A O   1 
ATOM   1262 C  CB  . SER A 1 185 ? -1.440  22.118  7.834   1.00 30.50 ? 190 SER A CB  1 
ATOM   1263 O  OG  . SER A 1 185 ? -0.113  21.733  7.571   1.00 34.54 ? 190 SER A OG  1 
ATOM   1264 N  N   . ALA A 1 186 ? -0.086  20.270  10.217  1.00 27.30 ? 191 ALA A N   1 
ATOM   1265 C  CA  . ALA A 1 186 ? 0.415   18.967  10.665  1.00 26.29 ? 191 ALA A CA  1 
ATOM   1266 C  C   . ALA A 1 186 ? -0.179  18.477  11.997  1.00 25.02 ? 191 ALA A C   1 
ATOM   1267 O  O   . ALA A 1 186 ? 0.063   17.336  12.393  1.00 24.86 ? 191 ALA A O   1 
ATOM   1268 C  CB  . ALA A 1 186 ? 1.955   18.964  10.729  1.00 26.03 ? 191 ALA A CB  1 
ATOM   1269 N  N   . SER A 1 187 ? -0.953  19.320  12.685  1.00 24.06 ? 192 SER A N   1 
ATOM   1270 C  CA  . SER A 1 187 ? -1.432  18.977  14.030  1.00 23.57 ? 192 SER A CA  1 
ATOM   1271 C  C   . SER A 1 187 ? -2.913  18.611  14.057  1.00 22.36 ? 192 SER A C   1 
ATOM   1272 O  O   . SER A 1 187 ? -3.498  18.497  15.117  1.00 21.25 ? 192 SER A O   1 
ATOM   1273 C  CB  . SER A 1 187 ? -1.169  20.124  15.018  1.00 24.12 ? 192 SER A CB  1 
ATOM   1274 O  OG  . SER A 1 187 ? 0.212   20.375  15.115  1.00 26.61 ? 192 SER A OG  1 
ATOM   1275 N  N   . ILE A 1 188 ? -3.510  18.442  12.886  1.00 21.54 ? 193 ILE A N   1 
ATOM   1276 C  CA  . ILE A 1 188 ? -4.911  17.988  12.790  1.00 20.04 ? 193 ILE A CA  1 
ATOM   1277 C  C   . ILE A 1 188 ? -5.038  16.821  11.811  1.00 18.47 ? 193 ILE A C   1 
ATOM   1278 O  O   . ILE A 1 188 ? -4.516  16.875  10.685  1.00 18.47 ? 193 ILE A O   1 
ATOM   1279 C  CB  . ILE A 1 188 ? -5.869  19.140  12.392  1.00 19.98 ? 193 ILE A CB  1 
ATOM   1280 C  CG1 . ILE A 1 188 ? -7.338  18.641  12.298  1.00 19.37 ? 193 ILE A CG1 1 
ATOM   1281 C  CG2 . ILE A 1 188 ? -5.469  19.792  11.083  1.00 21.18 ? 193 ILE A CG2 1 
ATOM   1282 C  CD1 . ILE A 1 188 ? -8.358  19.755  12.158  1.00 17.51 ? 193 ILE A CD1 1 
ATOM   1283 N  N   . VAL A 1 189 ? -5.729  15.761  12.244  1.00 17.17 ? 194 VAL A N   1 
ATOM   1284 C  CA  . VAL A 1 189 ? -6.000  14.639  11.380  1.00 15.19 ? 194 VAL A CA  1 
ATOM   1285 C  C   . VAL A 1 189 ? -7.515  14.421  11.385  1.00 14.37 ? 194 VAL A C   1 
ATOM   1286 O  O   . VAL A 1 189 ? -8.087  14.438  12.459  1.00 13.26 ? 194 VAL A O   1 
ATOM   1287 C  CB  . VAL A 1 189 ? -5.293  13.429  11.889  1.00 15.78 ? 194 VAL A CB  1 
ATOM   1288 C  CG1 . VAL A 1 189 ? -5.805  12.119  11.195  1.00 15.10 ? 194 VAL A CG1 1 
ATOM   1289 C  CG2 . VAL A 1 189 ? -3.761  13.615  11.682  1.00 15.93 ? 194 VAL A CG2 1 
ATOM   1290 N  N   . TYR A 1 190 ? -8.112  14.266  10.190  1.00 14.16 ? 195 TYR A N   1 
ATOM   1291 C  CA  . TYR A 1 190 ? -9.560  13.967  10.024  1.00 14.78 ? 195 TYR A CA  1 
ATOM   1292 C  C   . TYR A 1 190 ? -9.813  12.469  9.917   1.00 14.93 ? 195 TYR A C   1 
ATOM   1293 O  O   . TYR A 1 190 ? -8.993  11.712  9.338   1.00 13.80 ? 195 TYR A O   1 
ATOM   1294 C  CB  . TYR A 1 190 ? -10.111 14.566  8.738   1.00 14.47 ? 195 TYR A CB  1 
ATOM   1295 C  CG  . TYR A 1 190 ? -10.180 16.076  8.690   1.00 16.69 ? 195 TYR A CG  1 
ATOM   1296 C  CD1 . TYR A 1 190 ? -11.304 16.755  9.175   1.00 15.44 ? 195 TYR A CD1 1 
ATOM   1297 C  CD2 . TYR A 1 190 ? -9.133  16.826  8.163   1.00 18.58 ? 195 TYR A CD2 1 
ATOM   1298 C  CE1 . TYR A 1 190 ? -11.370 18.138  9.161   1.00 16.93 ? 195 TYR A CE1 1 
ATOM   1299 C  CE2 . TYR A 1 190 ? -9.197  18.213  8.141   1.00 18.93 ? 195 TYR A CE2 1 
ATOM   1300 C  CZ  . TYR A 1 190 ? -10.338 18.851  8.613   1.00 20.17 ? 195 TYR A CZ  1 
ATOM   1301 O  OH  . TYR A 1 190 ? -10.450 20.211  8.562   1.00 20.79 ? 195 TYR A OH  1 
ATOM   1302 N  N   . ILE A 1 191 ? -10.985 12.028  10.392  1.00 13.19 ? 196 ILE A N   1 
ATOM   1303 C  CA  . ILE A 1 191 ? -11.324 10.629  10.235  1.00 12.95 ? 196 ILE A CA  1 
ATOM   1304 C  C   . ILE A 1 191 ? -12.808 10.646  9.890   1.00 12.62 ? 196 ILE A C   1 
ATOM   1305 O  O   . ILE A 1 191 ? -13.580 11.267  10.608  1.00 12.53 ? 196 ILE A O   1 
ATOM   1306 C  CB  . ILE A 1 191 ? -11.170 9.843   11.561  1.00 12.42 ? 196 ILE A CB  1 
ATOM   1307 C  CG1 . ILE A 1 191 ? -9.704  9.775   12.024  1.00 13.13 ? 196 ILE A CG1 1 
ATOM   1308 C  CG2 . ILE A 1 191 ? -11.748 8.411   11.416  1.00 10.60 ? 196 ILE A CG2 1 
ATOM   1309 C  CD1 . ILE A 1 191 ? -9.557  9.168   13.445  1.00 12.19 ? 196 ILE A CD1 1 
ATOM   1310 N  N   . GLY A 1 192 ? -13.193 9.997   8.801   1.00 12.44 ? 197 GLY A N   1 
ATOM   1311 C  CA  . GLY A 1 192 ? -14.632 9.779   8.523   1.00 12.47 ? 197 GLY A CA  1 
ATOM   1312 C  C   . GLY A 1 192 ? -15.142 10.479  7.277   1.00 12.80 ? 197 GLY A C   1 
ATOM   1313 O  O   . GLY A 1 192 ? -16.324 10.354  6.927   1.00 11.52 ? 197 GLY A O   1 
ATOM   1314 N  N   . LEU A 1 193 ? -14.262 11.242  6.629   1.00 13.01 ? 198 LEU A N   1 
ATOM   1315 C  CA  . LEU A 1 193 ? -14.657 12.184  5.556   1.00 14.50 ? 198 LEU A CA  1 
ATOM   1316 C  C   . LEU A 1 193 ? -15.349 11.478  4.428   1.00 14.94 ? 198 LEU A C   1 
ATOM   1317 O  O   . LEU A 1 193 ? -14.875 10.443  3.954   1.00 15.48 ? 198 LEU A O   1 
ATOM   1318 C  CB  . LEU A 1 193 ? -13.417 12.946  5.005   1.00 14.77 ? 198 LEU A CB  1 
ATOM   1319 C  CG  . LEU A 1 193 ? -12.676 13.884  5.988   1.00 15.02 ? 198 LEU A CG  1 
ATOM   1320 C  CD1 . LEU A 1 193 ? -11.650 14.696  5.248   1.00 16.03 ? 198 LEU A CD1 1 
ATOM   1321 C  CD2 . LEU A 1 193 ? -13.641 14.816  6.713   1.00 13.16 ? 198 LEU A CD2 1 
ATOM   1322 N  N   . ARG A 1 194 ? -16.473 12.037  3.990   1.00 17.00 ? 199 ARG A N   1 
ATOM   1323 C  CA  . ARG A 1 194 ? -17.204 11.515  2.820   1.00 17.52 ? 199 ARG A CA  1 
ATOM   1324 C  C   . ARG A 1 194 ? -18.029 12.568  2.039   1.00 18.49 ? 199 ARG A C   1 
ATOM   1325 O  O   . ARG A 1 194 ? -18.626 12.239  1.032   1.00 18.71 ? 199 ARG A O   1 
ATOM   1326 C  CB  . ARG A 1 194 ? -18.103 10.335  3.196   1.00 16.97 ? 199 ARG A CB  1 
ATOM   1327 C  CG  . ARG A 1 194 ? -19.174 10.617  4.276   1.00 16.99 ? 199 ARG A CG  1 
ATOM   1328 C  CD  . ARG A 1 194 ? -19.803 9.272   4.668   1.00 14.86 ? 199 ARG A CD  1 
ATOM   1329 N  NE  . ARG A 1 194 ? -20.857 9.418   5.682   1.00 14.04 ? 199 ARG A NE  1 
ATOM   1330 C  CZ  . ARG A 1 194 ? -20.659 9.555   6.997   1.00 15.34 ? 199 ARG A CZ  1 
ATOM   1331 N  NH1 . ARG A 1 194 ? -19.416 9.574   7.538   1.00 15.09 ? 199 ARG A NH1 1 
ATOM   1332 N  NH2 . ARG A 1 194 ? -21.732 9.653   7.795   1.00 11.60 ? 199 ARG A NH2 1 
ATOM   1333 N  N   . ASP A 1 195 ? -18.036 13.823  2.489   1.00 19.26 ? 200 ASP A N   1 
ATOM   1334 C  CA  . ASP A 1 195 ? -18.851 14.884  1.848   1.00 21.61 ? 200 ASP A CA  1 
ATOM   1335 C  C   . ASP A 1 195 ? -17.954 16.135  1.891   1.00 22.08 ? 200 ASP A C   1 
ATOM   1336 O  O   . ASP A 1 195 ? -18.054 16.967  2.780   1.00 22.67 ? 200 ASP A O   1 
ATOM   1337 C  CB  . ASP A 1 195 ? -20.188 15.041  2.603   1.00 21.91 ? 200 ASP A CB  1 
ATOM   1338 C  CG  . ASP A 1 195 ? -21.099 16.174  2.067   1.00 26.57 ? 200 ASP A CG  1 
ATOM   1339 O  OD1 . ASP A 1 195 ? -20.971 16.600  0.897   1.00 28.36 ? 200 ASP A OD1 1 
ATOM   1340 O  OD2 . ASP A 1 195 ? -21.967 16.627  2.860   1.00 29.02 ? 200 ASP A OD2 1 
ATOM   1341 N  N   . VAL A 1 196 ? -17.012 16.189  0.954   1.00 21.92 ? 201 VAL A N   1 
ATOM   1342 C  CA  . VAL A 1 196 ? -15.987 17.209  0.914   1.00 22.35 ? 201 VAL A CA  1 
ATOM   1343 C  C   . VAL A 1 196 ? -16.266 18.107  -0.298  1.00 23.84 ? 201 VAL A C   1 
ATOM   1344 O  O   . VAL A 1 196 ? -16.380 17.605  -1.433  1.00 23.56 ? 201 VAL A O   1 
ATOM   1345 C  CB  . VAL A 1 196 ? -14.564 16.573  0.823   1.00 22.26 ? 201 VAL A CB  1 
ATOM   1346 C  CG1 . VAL A 1 196 ? -13.498 17.637  0.854   1.00 22.60 ? 201 VAL A CG1 1 
ATOM   1347 C  CG2 . VAL A 1 196 ? -14.329 15.581  1.977   1.00 20.59 ? 201 VAL A CG2 1 
ATOM   1348 N  N   . ASP A 1 197 ? -16.399 19.420  -0.054  1.00 23.94 ? 202 ASP A N   1 
ATOM   1349 C  CA  . ASP A 1 197 ? -16.546 20.396  -1.147  1.00 24.86 ? 202 ASP A CA  1 
ATOM   1350 C  C   . ASP A 1 197 ? -15.247 20.472  -1.983  1.00 24.25 ? 202 ASP A C   1 
ATOM   1351 O  O   . ASP A 1 197 ? -14.144 20.303  -1.440  1.00 24.69 ? 202 ASP A O   1 
ATOM   1352 C  CB  . ASP A 1 197 ? -16.911 21.806  -0.608  1.00 24.51 ? 202 ASP A CB  1 
ATOM   1353 C  CG  . ASP A 1 197 ? -18.276 21.873  0.067   1.00 27.33 ? 202 ASP A CG  1 
ATOM   1354 O  OD1 . ASP A 1 197 ? -19.125 20.969  -0.113  1.00 27.20 ? 202 ASP A OD1 1 
ATOM   1355 O  OD2 . ASP A 1 197 ? -18.521 22.882  0.775   1.00 28.70 ? 202 ASP A OD2 1 
ATOM   1356 N  N   . PRO A 1 198 ? -15.348 20.741  -3.314  1.00 24.70 ? 203 PRO A N   1 
ATOM   1357 C  CA  . PRO A 1 198 ? -14.064 20.870  -4.064  1.00 24.74 ? 203 PRO A CA  1 
ATOM   1358 C  C   . PRO A 1 198 ? -13.021 21.845  -3.484  1.00 24.66 ? 203 PRO A C   1 
ATOM   1359 O  O   . PRO A 1 198 ? -11.852 21.468  -3.379  1.00 24.58 ? 203 PRO A O   1 
ATOM   1360 C  CB  . PRO A 1 198 ? -14.498 21.239  -5.499  1.00 24.60 ? 203 PRO A CB  1 
ATOM   1361 C  CG  . PRO A 1 198 ? -15.935 20.682  -5.589  1.00 25.05 ? 203 PRO A CG  1 
ATOM   1362 C  CD  . PRO A 1 198 ? -16.525 20.821  -4.197  1.00 24.81 ? 203 PRO A CD  1 
ATOM   1363 N  N   . PRO A 1 199 ? -13.420 23.070  -3.072  1.00 24.83 ? 204 PRO A N   1 
ATOM   1364 C  CA  . PRO A 1 199 ? -12.362 23.907  -2.475  1.00 24.86 ? 204 PRO A CA  1 
ATOM   1365 C  C   . PRO A 1 199 ? -11.758 23.312  -1.188  1.00 24.50 ? 204 PRO A C   1 
ATOM   1366 O  O   . PRO A 1 199 ? -10.575 23.530  -0.899  1.00 24.74 ? 204 PRO A O   1 
ATOM   1367 C  CB  . PRO A 1 199 ? -13.071 25.253  -2.215  1.00 25.05 ? 204 PRO A CB  1 
ATOM   1368 C  CG  . PRO A 1 199 ? -14.516 24.960  -2.232  1.00 25.36 ? 204 PRO A CG  1 
ATOM   1369 C  CD  . PRO A 1 199 ? -14.696 23.799  -3.186  1.00 25.03 ? 204 PRO A CD  1 
ATOM   1370 N  N   . GLU A 1 200 ? -12.549 22.542  -0.439  1.00 24.09 ? 205 GLU A N   1 
ATOM   1371 C  CA  . GLU A 1 200 ? -12.026 21.801  0.727   1.00 23.03 ? 205 GLU A CA  1 
ATOM   1372 C  C   . GLU A 1 200 ? -11.024 20.726  0.332   1.00 23.42 ? 205 GLU A C   1 
ATOM   1373 O  O   . GLU A 1 200 ? -9.977  20.563  0.963   1.00 22.71 ? 205 GLU A O   1 
ATOM   1374 C  CB  . GLU A 1 200 ? -13.184 21.198  1.518   1.00 23.44 ? 205 GLU A CB  1 
ATOM   1375 C  CG  . GLU A 1 200 ? -14.012 22.228  2.218   1.00 20.99 ? 205 GLU A CG  1 
ATOM   1376 C  CD  . GLU A 1 200 ? -15.137 21.588  3.005   1.00 25.08 ? 205 GLU A CD  1 
ATOM   1377 O  OE1 . GLU A 1 200 ? -15.945 20.861  2.378   1.00 20.36 ? 205 GLU A OE1 1 
ATOM   1378 O  OE2 . GLU A 1 200 ? -15.200 21.808  4.249   1.00 23.74 ? 205 GLU A OE2 1 
ATOM   1379 N  N   . HIS A 1 201 ? -11.337 19.984  -0.728  1.00 23.64 ? 206 HIS A N   1 
ATOM   1380 C  CA  . HIS A 1 201 ? -10.395 18.997  -1.245  1.00 24.62 ? 206 HIS A CA  1 
ATOM   1381 C  C   . HIS A 1 201 ? -9.058  19.666  -1.604  1.00 24.96 ? 206 HIS A C   1 
ATOM   1382 O  O   . HIS A 1 201 ? -7.970  19.181  -1.230  1.00 24.11 ? 206 HIS A O   1 
ATOM   1383 C  CB  . HIS A 1 201 ? -10.994 18.256  -2.450  1.00 24.65 ? 206 HIS A CB  1 
ATOM   1384 C  CG  . HIS A 1 201 ? -10.081 17.214  -3.021  1.00 26.51 ? 206 HIS A CG  1 
ATOM   1385 N  ND1 . HIS A 1 201 ? -9.174  17.485  -4.024  1.00 30.10 ? 206 HIS A ND1 1 
ATOM   1386 C  CD2 . HIS A 1 201 ? -9.910  15.909  -2.705  1.00 27.27 ? 206 HIS A CD2 1 
ATOM   1387 C  CE1 . HIS A 1 201 ? -8.488  16.391  -4.307  1.00 28.51 ? 206 HIS A CE1 1 
ATOM   1388 N  NE2 . HIS A 1 201 ? -8.910  15.421  -3.514  1.00 28.25 ? 206 HIS A NE2 1 
ATOM   1389 N  N   . PHE A 1 202 ? -9.146  20.800  -2.304  1.00 25.65 ? 207 PHE A N   1 
ATOM   1390 C  CA  . PHE A 1 202 ? -7.940  21.574  -2.667  1.00 26.32 ? 207 PHE A CA  1 
ATOM   1391 C  C   . PHE A 1 202 ? -7.075  21.955  -1.452  1.00 25.69 ? 207 PHE A C   1 
ATOM   1392 O  O   . PHE A 1 202 ? -5.840  21.774  -1.457  1.00 25.15 ? 207 PHE A O   1 
ATOM   1393 C  CB  . PHE A 1 202 ? -8.319  22.859  -3.427  1.00 26.88 ? 207 PHE A CB  1 
ATOM   1394 C  CG  . PHE A 1 202 ? -7.129  23.777  -3.664  1.00 29.35 ? 207 PHE A CG  1 
ATOM   1395 C  CD1 . PHE A 1 202 ? -6.292  23.572  -4.762  1.00 30.52 ? 207 PHE A CD1 1 
ATOM   1396 C  CD2 . PHE A 1 202 ? -6.819  24.796  -2.755  1.00 29.17 ? 207 PHE A CD2 1 
ATOM   1397 C  CE1 . PHE A 1 202 ? -5.161  24.403  -4.986  1.00 33.50 ? 207 PHE A CE1 1 
ATOM   1398 C  CE2 . PHE A 1 202 ? -5.693  25.631  -2.958  1.00 33.15 ? 207 PHE A CE2 1 
ATOM   1399 C  CZ  . PHE A 1 202 ? -4.864  25.432  -4.077  1.00 32.76 ? 207 PHE A CZ  1 
ATOM   1400 N  N   . ILE A 1 203 ? -7.725  22.501  -0.427  1.00 25.53 ? 208 ILE A N   1 
ATOM   1401 C  CA  . ILE A 1 203 ? -7.022  22.870  0.816   1.00 26.01 ? 208 ILE A CA  1 
ATOM   1402 C  C   . ILE A 1 203 ? -6.337  21.662  1.433   1.00 26.07 ? 208 ILE A C   1 
ATOM   1403 O  O   . ILE A 1 203 ? -5.127  21.703  1.735   1.00 25.67 ? 208 ILE A O   1 
ATOM   1404 C  CB  . ILE A 1 203 ? -7.947  23.554  1.853   1.00 25.60 ? 208 ILE A CB  1 
ATOM   1405 C  CG1 . ILE A 1 203 ? -8.452  24.891  1.293   1.00 27.17 ? 208 ILE A CG1 1 
ATOM   1406 C  CG2 . ILE A 1 203 ? -7.178  23.794  3.170   1.00 25.85 ? 208 ILE A CG2 1 
ATOM   1407 C  CD1 . ILE A 1 203 ? -9.721  25.457  1.925   1.00 26.74 ? 208 ILE A CD1 1 
ATOM   1408 N  N   . LEU A 1 204 ? -7.100  20.573  1.581   1.00 26.26 ? 209 LEU A N   1 
ATOM   1409 C  CA  . LEU A 1 204 ? -6.552  19.369  2.196   1.00 26.47 ? 209 LEU A CA  1 
ATOM   1410 C  C   . LEU A 1 204 ? -5.282  18.942  1.453   1.00 26.71 ? 209 LEU A C   1 
ATOM   1411 O  O   . LEU A 1 204 ? -4.233  18.738  2.056   1.00 24.97 ? 209 LEU A O   1 
ATOM   1412 C  CB  . LEU A 1 204 ? -7.588  18.230  2.249   1.00 25.76 ? 209 LEU A CB  1 
ATOM   1413 C  CG  . LEU A 1 204 ? -8.795  18.389  3.200   1.00 25.85 ? 209 LEU A CG  1 
ATOM   1414 C  CD1 . LEU A 1 204 ? -9.809  17.242  3.032   1.00 25.78 ? 209 LEU A CD1 1 
ATOM   1415 C  CD2 . LEU A 1 204 ? -8.386  18.514  4.646   1.00 23.83 ? 209 LEU A CD2 1 
ATOM   1416 N  N   . LYS A 1 205 ? -5.369  18.824  0.136   1.00 27.50 ? 210 LYS A N   1 
ATOM   1417 C  CA  . LYS A 1 205 ? -4.189  18.330  -0.612  1.00 28.23 ? 210 LYS A CA  1 
ATOM   1418 C  C   . LYS A 1 205 ? -3.046  19.346  -0.603  1.00 28.36 ? 210 LYS A C   1 
ATOM   1419 O  O   . LYS A 1 205 ? -1.892  19.004  -0.336  1.00 27.99 ? 210 LYS A O   1 
ATOM   1420 C  CB  . LYS A 1 205 ? -4.564  17.987  -2.051  1.00 28.13 ? 210 LYS A CB  1 
ATOM   1421 C  CG  . LYS A 1 205 ? -5.517  16.782  -2.183  1.00 30.85 ? 210 LYS A CG  1 
ATOM   1422 C  CD  . LYS A 1 205 ? -4.880  15.474  -1.711  1.00 33.86 ? 210 LYS A CD  1 
ATOM   1423 C  CE  . LYS A 1 205 ? -5.732  14.273  -2.121  1.00 34.94 ? 210 LYS A CE  1 
ATOM   1424 N  NZ  . LYS A 1 205 ? -4.922  13.024  -2.022  1.00 36.75 ? 210 LYS A NZ  1 
ATOM   1425 N  N   . ASN A 1 206 ? -3.393  20.595  -0.898  1.00 28.98 ? 211 ASN A N   1 
ATOM   1426 C  CA  . ASN A 1 206 ? -2.406  21.666  -1.005  1.00 30.18 ? 211 ASN A CA  1 
ATOM   1427 C  C   . ASN A 1 206 ? -1.686  22.045  0.282   1.00 29.61 ? 211 ASN A C   1 
ATOM   1428 O  O   . ASN A 1 206 ? -0.516  22.448  0.237   1.00 29.54 ? 211 ASN A O   1 
ATOM   1429 C  CB  . ASN A 1 206 ? -3.019  22.900  -1.648  1.00 30.43 ? 211 ASN A CB  1 
ATOM   1430 C  CG  . ASN A 1 206 ? -2.660  23.010  -3.098  1.00 34.22 ? 211 ASN A CG  1 
ATOM   1431 O  OD1 . ASN A 1 206 ? -1.973  23.953  -3.498  1.00 41.07 ? 211 ASN A OD1 1 
ATOM   1432 N  ND2 . ASN A 1 206 ? -3.062  22.028  -3.894  1.00 35.65 ? 211 ASN A ND2 1 
ATOM   1433 N  N   . TYR A 1 207 ? -2.362  21.924  1.425   1.00 28.38 ? 212 TYR A N   1 
ATOM   1434 C  CA  . TYR A 1 207 ? -1.668  22.145  2.692   1.00 28.17 ? 212 TYR A CA  1 
ATOM   1435 C  C   . TYR A 1 207 ? -1.227  20.862  3.360   1.00 27.47 ? 212 TYR A C   1 
ATOM   1436 O  O   . TYR A 1 207 ? -0.784  20.869  4.510   1.00 27.85 ? 212 TYR A O   1 
ATOM   1437 C  CB  . TYR A 1 207 ? -2.491  23.032  3.638   1.00 27.97 ? 212 TYR A CB  1 
ATOM   1438 C  CG  . TYR A 1 207 ? -2.719  24.399  3.076   1.00 29.61 ? 212 TYR A CG  1 
ATOM   1439 C  CD1 . TYR A 1 207 ? -3.784  24.638  2.209   1.00 29.77 ? 212 TYR A CD1 1 
ATOM   1440 C  CD2 . TYR A 1 207 ? -1.851  25.463  3.401   1.00 31.71 ? 212 TYR A CD2 1 
ATOM   1441 C  CE1 . TYR A 1 207 ? -3.997  25.892  1.669   1.00 33.01 ? 212 TYR A CE1 1 
ATOM   1442 C  CE2 . TYR A 1 207 ? -2.057  26.744  2.875   1.00 32.33 ? 212 TYR A CE2 1 
ATOM   1443 C  CZ  . TYR A 1 207 ? -3.131  26.947  2.000   1.00 33.13 ? 212 TYR A CZ  1 
ATOM   1444 O  OH  . TYR A 1 207 ? -3.388  28.184  1.460   1.00 32.69 ? 212 TYR A OH  1 
ATOM   1445 N  N   . ASP A 1 208 ? -1.334  19.757  2.622   1.00 27.44 ? 213 ASP A N   1 
ATOM   1446 C  CA  . ASP A 1 208 ? -0.879  18.454  3.094   1.00 26.87 ? 213 ASP A CA  1 
ATOM   1447 C  C   . ASP A 1 208 ? -1.528  18.042  4.408   1.00 25.35 ? 213 ASP A C   1 
ATOM   1448 O  O   . ASP A 1 208 ? -0.869  17.486  5.274   1.00 24.72 ? 213 ASP A O   1 
ATOM   1449 C  CB  . ASP A 1 208 ? 0.625   18.458  3.275   1.00 28.56 ? 213 ASP A CB  1 
ATOM   1450 C  CG  . ASP A 1 208 ? 1.288   17.493  2.368   1.00 33.30 ? 213 ASP A CG  1 
ATOM   1451 O  OD1 . ASP A 1 208 ? 1.262   16.268  2.680   1.00 36.04 ? 213 ASP A OD1 1 
ATOM   1452 O  OD2 . ASP A 1 208 ? 1.807   17.974  1.335   1.00 38.13 ? 213 ASP A OD2 1 
ATOM   1453 N  N   . ILE A 1 209 ? -2.813  18.336  4.556   1.00 23.61 ? 214 ILE A N   1 
ATOM   1454 C  CA  . ILE A 1 209 ? -3.513  17.952  5.776   1.00 22.77 ? 214 ILE A CA  1 
ATOM   1455 C  C   . ILE A 1 209 ? -3.878  16.470  5.673   1.00 21.85 ? 214 ILE A C   1 
ATOM   1456 O  O   . ILE A 1 209 ? -4.427  16.051  4.671   1.00 22.15 ? 214 ILE A O   1 
ATOM   1457 C  CB  . ILE A 1 209 ? -4.737  18.849  6.021   1.00 22.76 ? 214 ILE A CB  1 
ATOM   1458 C  CG1 . ILE A 1 209 ? -4.281  20.308  6.171   1.00 23.36 ? 214 ILE A CG1 1 
ATOM   1459 C  CG2 . ILE A 1 209 ? -5.512  18.420  7.281   1.00 22.46 ? 214 ILE A CG2 1 
ATOM   1460 C  CD1 . ILE A 1 209 ? -5.421  21.321  6.046   1.00 23.08 ? 214 ILE A CD1 1 
ATOM   1461 N  N   . GLN A 1 210 ? -3.557  15.692  6.697   1.00 21.18 ? 215 GLN A N   1 
ATOM   1462 C  CA  . GLN A 1 210 ? -3.714  14.238  6.626   1.00 20.76 ? 215 GLN A CA  1 
ATOM   1463 C  C   . GLN A 1 210 ? -5.141  13.874  6.989   1.00 19.67 ? 215 GLN A C   1 
ATOM   1464 O  O   . GLN A 1 210 ? -5.697  14.380  7.976   1.00 19.22 ? 215 GLN A O   1 
ATOM   1465 C  CB  . GLN A 1 210 ? -2.718  13.543  7.551   1.00 21.73 ? 215 GLN A CB  1 
ATOM   1466 C  CG  . GLN A 1 210 ? -1.210  13.821  7.206   1.00 22.97 ? 215 GLN A CG  1 
ATOM   1467 C  CD  . GLN A 1 210 ? -0.857  13.441  5.776   1.00 26.31 ? 215 GLN A CD  1 
ATOM   1468 O  OE1 . GLN A 1 210 ? -0.926  12.275  5.398   1.00 27.12 ? 215 GLN A OE1 1 
ATOM   1469 N  NE2 . GLN A 1 210 ? -0.487  14.436  4.971   1.00 26.39 ? 215 GLN A NE2 1 
ATOM   1470 N  N   . TYR A 1 211 ? -5.751  13.017  6.186   1.00 18.66 ? 216 TYR A N   1 
ATOM   1471 C  CA  . TYR A 1 211 ? -7.092  12.562  6.510   1.00 17.62 ? 216 TYR A CA  1 
ATOM   1472 C  C   . TYR A 1 211 ? -7.277  11.089  6.163   1.00 17.74 ? 216 TYR A C   1 
ATOM   1473 O  O   . TYR A 1 211 ? -6.609  10.553  5.266   1.00 17.08 ? 216 TYR A O   1 
ATOM   1474 C  CB  . TYR A 1 211 ? -8.140  13.437  5.821   1.00 17.29 ? 216 TYR A CB  1 
ATOM   1475 C  CG  . TYR A 1 211 ? -8.131  13.427  4.290   1.00 19.68 ? 216 TYR A CG  1 
ATOM   1476 C  CD1 . TYR A 1 211 ? -8.878  12.491  3.578   1.00 19.14 ? 216 TYR A CD1 1 
ATOM   1477 C  CD2 . TYR A 1 211 ? -7.376  14.362  3.567   1.00 22.14 ? 216 TYR A CD2 1 
ATOM   1478 C  CE1 . TYR A 1 211 ? -8.909  12.487  2.182   1.00 23.97 ? 216 TYR A CE1 1 
ATOM   1479 C  CE2 . TYR A 1 211 ? -7.369  14.368  2.156   1.00 24.60 ? 216 TYR A CE2 1 
ATOM   1480 C  CZ  . TYR A 1 211 ? -8.143  13.438  1.470   1.00 26.29 ? 216 TYR A CZ  1 
ATOM   1481 O  OH  . TYR A 1 211 ? -8.166  13.416  0.085   1.00 28.70 ? 216 TYR A OH  1 
ATOM   1482 N  N   . PHE A 1 212 ? -8.172  10.452  6.916   1.00 16.03 ? 217 PHE A N   1 
ATOM   1483 C  CA  . PHE A 1 212 ? -8.653  9.127   6.633   1.00 15.91 ? 217 PHE A CA  1 
ATOM   1484 C  C   . PHE A 1 212 ? -10.134 9.231   6.276   1.00 15.38 ? 217 PHE A C   1 
ATOM   1485 O  O   . PHE A 1 212 ? -10.980 9.344   7.156   1.00 15.60 ? 217 PHE A O   1 
ATOM   1486 C  CB  . PHE A 1 212 ? -8.399  8.246   7.864   1.00 15.91 ? 217 PHE A CB  1 
ATOM   1487 C  CG  . PHE A 1 212 ? -6.919  8.152   8.229   1.00 16.55 ? 217 PHE A CG  1 
ATOM   1488 C  CD1 . PHE A 1 212 ? -6.349  9.052   9.133   1.00 14.77 ? 217 PHE A CD1 1 
ATOM   1489 C  CD2 . PHE A 1 212 ? -6.101  7.179   7.630   1.00 17.27 ? 217 PHE A CD2 1 
ATOM   1490 C  CE1 . PHE A 1 212 ? -4.957  8.967   9.452   1.00 19.47 ? 217 PHE A CE1 1 
ATOM   1491 C  CE2 . PHE A 1 212 ? -4.729  7.095   7.932   1.00 19.81 ? 217 PHE A CE2 1 
ATOM   1492 C  CZ  . PHE A 1 212 ? -4.168  7.985   8.846   1.00 18.54 ? 217 PHE A CZ  1 
ATOM   1493 N  N   . SER A 1 213 ? -10.421 9.266   4.974   1.00 15.15 ? 218 SER A N   1 
ATOM   1494 C  CA  . SER A 1 213 ? -11.792 9.297   4.451   1.00 14.44 ? 218 SER A CA  1 
ATOM   1495 C  C   . SER A 1 213 ? -12.451 7.943   4.729   1.00 14.09 ? 218 SER A C   1 
ATOM   1496 O  O   . SER A 1 213 ? -11.776 6.991   5.145   1.00 14.19 ? 218 SER A O   1 
ATOM   1497 C  CB  . SER A 1 213 ? -11.768 9.581   2.952   1.00 14.91 ? 218 SER A CB  1 
ATOM   1498 O  OG  . SER A 1 213 ? -11.358 8.405   2.256   1.00 15.31 ? 218 SER A OG  1 
ATOM   1499 N  N   . MET A 1 214 ? -13.766 7.834   4.531   1.00 14.12 ? 219 MET A N   1 
ATOM   1500 C  CA  . MET A 1 214 ? -14.388 6.511   4.669   1.00 13.74 ? 219 MET A CA  1 
ATOM   1501 C  C   . MET A 1 214 ? -13.681 5.502   3.763   1.00 13.80 ? 219 MET A C   1 
ATOM   1502 O  O   . MET A 1 214 ? -13.522 4.321   4.111   1.00 14.09 ? 219 MET A O   1 
ATOM   1503 C  CB  . MET A 1 214 ? -15.881 6.565   4.307   1.00 13.22 ? 219 MET A CB  1 
ATOM   1504 C  CG  . MET A 1 214 ? -16.704 7.414   5.269   1.00 12.98 ? 219 MET A CG  1 
ATOM   1505 S  SD  . MET A 1 214 ? -16.542 6.967   7.018   1.00 14.46 ? 219 MET A SD  1 
ATOM   1506 C  CE  . MET A 1 214 ? -16.674 5.187   6.999   1.00 11.84 ? 219 MET A CE  1 
ATOM   1507 N  N   . ARG A 1 215 ? -13.259 5.968   2.594   1.00 13.97 ? 220 ARG A N   1 
ATOM   1508 C  CA  . ARG A 1 215 ? -12.534 5.092   1.668   1.00 14.74 ? 220 ARG A CA  1 
ATOM   1509 C  C   . ARG A 1 215 ? -11.239 4.578   2.290   1.00 14.71 ? 220 ARG A C   1 
ATOM   1510 O  O   . ARG A 1 215 ? -10.875 3.408   2.135   1.00 13.88 ? 220 ARG A O   1 
ATOM   1511 C  CB  . ARG A 1 215 ? -12.233 5.848   0.365   1.00 15.37 ? 220 ARG A CB  1 
ATOM   1512 C  CG  . ARG A 1 215 ? -11.477 5.000   -0.659  1.00 17.02 ? 220 ARG A CG  1 
ATOM   1513 C  CD  . ARG A 1 215 ? -11.034 5.843   -1.864  1.00 20.48 ? 220 ARG A CD  1 
ATOM   1514 N  NE  . ARG A 1 215 ? -9.889  5.185   -2.471  1.00 19.90 ? 220 ARG A NE  1 
ATOM   1515 C  CZ  . ARG A 1 215 ? -9.941  4.209   -3.373  1.00 24.02 ? 220 ARG A CZ  1 
ATOM   1516 N  NH1 . ARG A 1 215 ? -11.131 3.756   -3.860  1.00 21.63 ? 220 ARG A NH1 1 
ATOM   1517 N  NH2 . ARG A 1 215 ? -8.779  3.686   -3.796  1.00 23.78 ? 220 ARG A NH2 1 
ATOM   1518 N  N   . ASP A 1 216 ? -10.535 5.462   3.005   1.00 14.35 ? 221 ASP A N   1 
ATOM   1519 C  CA  . ASP A 1 216 ? -9.330  5.046   3.687   1.00 15.23 ? 221 ASP A CA  1 
ATOM   1520 C  C   . ASP A 1 216 ? -9.599  4.003   4.769   1.00 14.28 ? 221 ASP A C   1 
ATOM   1521 O  O   . ASP A 1 216 ? -8.822  3.087   4.916   1.00 14.30 ? 221 ASP A O   1 
ATOM   1522 C  CB  . ASP A 1 216 ? -8.572  6.241   4.256   1.00 14.25 ? 221 ASP A CB  1 
ATOM   1523 C  CG  . ASP A 1 216 ? -8.010  7.119   3.164   1.00 18.92 ? 221 ASP A CG  1 
ATOM   1524 O  OD1 . ASP A 1 216 ? -7.419  6.561   2.226   1.00 18.26 ? 221 ASP A OD1 1 
ATOM   1525 O  OD2 . ASP A 1 216 ? -8.168  8.348   3.238   1.00 20.63 ? 221 ASP A OD2 1 
ATOM   1526 N  N   . ILE A 1 217 ? -10.719 4.148   5.493   1.00 13.92 ? 222 ILE A N   1 
ATOM   1527 C  CA  . ILE A 1 217 ? -11.129 3.186   6.514   1.00 13.55 ? 222 ILE A CA  1 
ATOM   1528 C  C   . ILE A 1 217 ? -11.494 1.846   5.842   1.00 13.33 ? 222 ILE A C   1 
ATOM   1529 O  O   . ILE A 1 217 ? -11.170 0.791   6.377   1.00 13.46 ? 222 ILE A O   1 
ATOM   1530 C  CB  . ILE A 1 217 ? -12.341 3.745   7.381   1.00 13.60 ? 222 ILE A CB  1 
ATOM   1531 C  CG1 . ILE A 1 217 ? -11.937 5.068   8.067   1.00 14.02 ? 222 ILE A CG1 1 
ATOM   1532 C  CG2 . ILE A 1 217 ? -12.835 2.709   8.392   1.00 13.53 ? 222 ILE A CG2 1 
ATOM   1533 C  CD1 . ILE A 1 217 ? -13.084 5.865   8.704   1.00 13.74 ? 222 ILE A CD1 1 
ATOM   1534 N  N   . ASP A 1 218 ? -12.185 1.900   4.697   1.00 14.57 ? 223 ASP A N   1 
ATOM   1535 C  CA  . ASP A 1 218 ? -12.556 0.679   3.927   1.00 14.65 ? 223 ASP A CA  1 
ATOM   1536 C  C   . ASP A 1 218 ? -11.311 -0.138  3.576   1.00 15.26 ? 223 ASP A C   1 
ATOM   1537 O  O   . ASP A 1 218 ? -11.323 -1.364  3.609   1.00 14.91 ? 223 ASP A O   1 
ATOM   1538 C  CB  . ASP A 1 218 ? -13.275 1.029   2.642   1.00 14.48 ? 223 ASP A CB  1 
ATOM   1539 C  CG  . ASP A 1 218 ? -14.661 1.639   2.871   1.00 14.75 ? 223 ASP A CG  1 
ATOM   1540 O  OD1 . ASP A 1 218 ? -15.281 1.366   3.917   1.00 14.05 ? 223 ASP A OD1 1 
ATOM   1541 O  OD2 . ASP A 1 218 ? -15.097 2.386   1.985   1.00 15.43 ? 223 ASP A OD2 1 
ATOM   1542 N  N   . ARG A 1 219 ? -10.241 0.570   3.250   1.00 15.75 ? 224 ARG A N   1 
ATOM   1543 C  CA  . ARG A 1 219 ? -8.961  -0.063  2.888   1.00 17.23 ? 224 ARG A CA  1 
ATOM   1544 C  C   . ARG A 1 219 ? -8.130  -0.531  4.100   1.00 17.45 ? 224 ARG A C   1 
ATOM   1545 O  O   . ARG A 1 219 ? -7.698  -1.678  4.177   1.00 17.70 ? 224 ARG A O   1 
ATOM   1546 C  CB  . ARG A 1 219 ? -8.155  0.947   2.061   1.00 17.04 ? 224 ARG A CB  1 
ATOM   1547 C  CG  . ARG A 1 219 ? -8.685  1.225   0.674   1.00 20.21 ? 224 ARG A CG  1 
ATOM   1548 C  CD  . ARG A 1 219 ? -8.049  2.515   0.050   1.00 22.35 ? 224 ARG A CD  1 
ATOM   1549 N  NE  . ARG A 1 219 ? -6.593  2.392   -0.004  1.00 25.39 ? 224 ARG A NE  1 
ATOM   1550 C  CZ  . ARG A 1 219 ? -5.935  1.677   -0.916  1.00 29.93 ? 224 ARG A CZ  1 
ATOM   1551 N  NH1 . ARG A 1 219 ? -6.595  1.022   -1.882  1.00 29.44 ? 224 ARG A NH1 1 
ATOM   1552 N  NH2 . ARG A 1 219 ? -4.604  1.625   -0.873  1.00 30.26 ? 224 ARG A NH2 1 
ATOM   1553 N  N   . LEU A 1 220 ? -7.876  0.376   5.039   1.00 16.87 ? 225 LEU A N   1 
ATOM   1554 C  CA  . LEU A 1 220 ? -6.994  0.080   6.160   1.00 15.82 ? 225 LEU A CA  1 
ATOM   1555 C  C   . LEU A 1 220 ? -7.654  -0.671  7.312   1.00 15.28 ? 225 LEU A C   1 
ATOM   1556 O  O   . LEU A 1 220 ? -7.032  -1.466  7.989   1.00 15.24 ? 225 LEU A O   1 
ATOM   1557 C  CB  . LEU A 1 220 ? -6.449  1.393   6.706   1.00 16.32 ? 225 LEU A CB  1 
ATOM   1558 C  CG  . LEU A 1 220 ? -5.476  2.119   5.775   1.00 17.43 ? 225 LEU A CG  1 
ATOM   1559 C  CD1 . LEU A 1 220 ? -5.387  3.582   6.195   1.00 18.09 ? 225 LEU A CD1 1 
ATOM   1560 C  CD2 . LEU A 1 220 ? -4.096  1.409   5.793   1.00 21.82 ? 225 LEU A CD2 1 
ATOM   1561 N  N   . GLY A 1 221 ? -8.924  -0.387  7.564   1.00 15.13 ? 226 GLY A N   1 
ATOM   1562 C  CA  . GLY A 1 221 ? -9.555  -0.852  8.785   1.00 14.67 ? 226 GLY A CA  1 
ATOM   1563 C  C   . GLY A 1 221 ? -9.324  0.173   9.875   1.00 16.46 ? 226 GLY A C   1 
ATOM   1564 O  O   . GLY A 1 221 ? -8.278  0.856   9.897   1.00 16.19 ? 226 GLY A O   1 
ATOM   1565 N  N   . ILE A 1 222 ? -10.283 0.275   10.797  1.00 16.32 ? 227 ILE A N   1 
ATOM   1566 C  CA  . ILE A 1 222 ? -10.218 1.278   11.860  1.00 16.59 ? 227 ILE A CA  1 
ATOM   1567 C  C   . ILE A 1 222 ? -9.004  1.126   12.810  1.00 17.58 ? 227 ILE A C   1 
ATOM   1568 O  O   . ILE A 1 222 ? -8.494  2.141   13.287  1.00 17.38 ? 227 ILE A O   1 
ATOM   1569 C  CB  . ILE A 1 222 ? -11.581 1.403   12.638  1.00 15.97 ? 227 ILE A CB  1 
ATOM   1570 C  CG1 . ILE A 1 222 ? -11.702 2.718   13.421  1.00 14.59 ? 227 ILE A CG1 1 
ATOM   1571 C  CG2 . ILE A 1 222 ? -11.807 0.247   13.591  1.00 16.50 ? 227 ILE A CG2 1 
ATOM   1572 C  CD1 . ILE A 1 222 ? -11.885 3.937   12.484  1.00 15.14 ? 227 ILE A CD1 1 
ATOM   1573 N  N   . GLN A 1 223 ? -8.535  -0.107  13.057  1.00 17.52 ? 228 GLN A N   1 
ATOM   1574 C  CA  . GLN A 1 223 ? -7.358  -0.305  13.901  1.00 18.75 ? 228 GLN A CA  1 
ATOM   1575 C  C   . GLN A 1 223 ? -6.160  0.429   13.294  1.00 18.27 ? 228 GLN A C   1 
ATOM   1576 O  O   . GLN A 1 223 ? -5.535  1.225   13.973  1.00 18.70 ? 228 GLN A O   1 
ATOM   1577 C  CB  . GLN A 1 223 ? -7.012  -1.796  14.180  1.00 18.93 ? 228 GLN A CB  1 
ATOM   1578 C  CG  . GLN A 1 223 ? -5.570  -1.948  14.799  1.00 21.27 ? 228 GLN A CG  1 
ATOM   1579 C  CD  . GLN A 1 223 ? -5.046  -3.374  14.917  1.00 26.83 ? 228 GLN A CD  1 
ATOM   1580 O  OE1 . GLN A 1 223 ? -3.893  -3.590  15.322  1.00 31.33 ? 228 GLN A OE1 1 
ATOM   1581 N  NE2 . GLN A 1 223 ? -5.866  -4.342  14.582  1.00 24.15 ? 228 GLN A NE2 1 
ATOM   1582 N  N   . LYS A 1 224 ? -5.865  0.197   12.019  1.00 18.41 ? 229 LYS A N   1 
ATOM   1583 C  CA  . LYS A 1 224 ? -4.682  0.843   11.397  1.00 18.46 ? 229 LYS A CA  1 
ATOM   1584 C  C   . LYS A 1 224 ? -4.871  2.363   11.235  1.00 18.38 ? 229 LYS A C   1 
ATOM   1585 O  O   . LYS A 1 224 ? -3.918  3.116   11.276  1.00 16.71 ? 229 LYS A O   1 
ATOM   1586 C  CB  . LYS A 1 224 ? -4.332  0.181   10.063  1.00 19.22 ? 229 LYS A CB  1 
ATOM   1587 C  CG  . LYS A 1 224 ? -3.701  -1.216  10.261  1.00 23.58 ? 229 LYS A CG  1 
ATOM   1588 C  CD  . LYS A 1 224 ? -3.265  -1.874  8.941   1.00 32.01 ? 229 LYS A CD  1 
ATOM   1589 C  CE  . LYS A 1 224 ? -1.747  -1.707  8.698   1.00 38.41 ? 229 LYS A CE  1 
ATOM   1590 N  NZ  . LYS A 1 224 ? -1.333  -1.999  7.254   1.00 42.16 ? 229 LYS A NZ  1 
ATOM   1591 N  N   . VAL A 1 225 ? -6.121  2.794   11.049  1.00 16.82 ? 230 VAL A N   1 
ATOM   1592 C  CA  . VAL A 1 225 ? -6.423  4.226   10.967  1.00 16.46 ? 230 VAL A CA  1 
ATOM   1593 C  C   . VAL A 1 225 ? -6.055  4.936   12.283  1.00 16.45 ? 230 VAL A C   1 
ATOM   1594 O  O   . VAL A 1 225 ? -5.454  6.031   12.258  1.00 17.34 ? 230 VAL A O   1 
ATOM   1595 C  CB  . VAL A 1 225 ? -7.918  4.474   10.614  1.00 16.00 ? 230 VAL A CB  1 
ATOM   1596 C  CG1 . VAL A 1 225 ? -8.314  5.944   10.896  1.00 15.23 ? 230 VAL A CG1 1 
ATOM   1597 C  CG2 . VAL A 1 225 ? -8.213  4.067   9.171   1.00 15.13 ? 230 VAL A CG2 1 
ATOM   1598 N  N   . MET A 1 226 ? -6.417  4.340   13.419  1.00 16.10 ? 231 MET A N   1 
ATOM   1599 C  CA  . MET A 1 226 ? -6.096  4.953   14.711  1.00 15.63 ? 231 MET A CA  1 
ATOM   1600 C  C   . MET A 1 226 ? -4.579  4.919   14.945  1.00 16.34 ? 231 MET A C   1 
ATOM   1601 O  O   . MET A 1 226 ? -4.010  5.938   15.406  1.00 15.84 ? 231 MET A O   1 
ATOM   1602 C  CB  . MET A 1 226 ? -6.839  4.292   15.882  1.00 15.44 ? 231 MET A CB  1 
ATOM   1603 C  CG  . MET A 1 226 ? -8.390  4.537   15.867  1.00 14.58 ? 231 MET A CG  1 
ATOM   1604 S  SD  . MET A 1 226 ? -8.792  6.240   15.403  1.00 15.75 ? 231 MET A SD  1 
ATOM   1605 C  CE  . MET A 1 226 ? -8.366  7.091   16.915  1.00 12.83 ? 231 MET A CE  1 
ATOM   1606 N  N   . GLU A 1 227 ? -3.950  3.775   14.645  1.00 16.21 ? 232 GLU A N   1 
ATOM   1607 C  CA  . GLU A 1 227 ? -2.469  3.653   14.781  1.00 18.24 ? 232 GLU A CA  1 
ATOM   1608 C  C   . GLU A 1 227 ? -1.785  4.755   13.976  1.00 18.18 ? 232 GLU A C   1 
ATOM   1609 O  O   . GLU A 1 227 ? -0.898  5.450   14.486  1.00 20.88 ? 232 GLU A O   1 
ATOM   1610 C  CB  . GLU A 1 227 ? -1.955  2.289   14.308  1.00 18.41 ? 232 GLU A CB  1 
ATOM   1611 C  CG  . GLU A 1 227 ? -2.091  1.163   15.355  1.00 21.64 ? 232 GLU A CG  1 
ATOM   1612 C  CD  . GLU A 1 227 ? -1.830  -0.250  14.778  1.00 23.08 ? 232 GLU A CD  1 
ATOM   1613 O  OE1 . GLU A 1 227 ? -1.342  -0.389  13.640  1.00 25.56 ? 232 GLU A OE1 1 
ATOM   1614 O  OE2 . GLU A 1 227 ? -2.138  -1.220  15.480  1.00 29.54 ? 232 GLU A OE2 1 
ATOM   1615 N  N   . ARG A 1 228 ? -2.164  4.892   12.710  1.00 19.00 ? 233 ARG A N   1 
ATOM   1616 C  CA  . ARG A 1 228 ? -1.522  5.903   11.856  1.00 19.74 ? 233 ARG A CA  1 
ATOM   1617 C  C   . ARG A 1 228 ? -1.832  7.317   12.286  1.00 18.67 ? 233 ARG A C   1 
ATOM   1618 O  O   . ARG A 1 228 ? -0.967  8.204   12.173  1.00 18.54 ? 233 ARG A O   1 
ATOM   1619 C  CB  . ARG A 1 228 ? -1.813  5.699   10.367  1.00 18.46 ? 233 ARG A CB  1 
ATOM   1620 C  CG  . ARG A 1 228 ? -1.288  4.368   9.894   1.00 22.82 ? 233 ARG A CG  1 
ATOM   1621 C  CD  . ARG A 1 228 ? -1.663  4.113   8.488   1.00 26.07 ? 233 ARG A CD  1 
ATOM   1622 N  NE  . ARG A 1 228 ? -1.163  2.816   8.018   1.00 28.71 ? 233 ARG A NE  1 
ATOM   1623 C  CZ  . ARG A 1 228 ? -0.910  2.553   6.739   1.00 29.17 ? 233 ARG A CZ  1 
ATOM   1624 N  NH1 . ARG A 1 228 ? -1.119  3.484   5.814   1.00 30.24 ? 233 ARG A NH1 1 
ATOM   1625 N  NH2 . ARG A 1 228 ? -0.452  1.362   6.385   1.00 31.67 ? 233 ARG A NH2 1 
ATOM   1626 N  N   . THR A 1 229 ? -3.057  7.537   12.772  1.00 17.47 ? 234 THR A N   1 
ATOM   1627 C  CA  . THR A 1 229 ? -3.433  8.836   13.306  1.00 17.50 ? 234 THR A CA  1 
ATOM   1628 C  C   . THR A 1 229 ? -2.521  9.268   14.458  1.00 18.60 ? 234 THR A C   1 
ATOM   1629 O  O   . THR A 1 229 ? -2.017  10.412  14.492  1.00 18.53 ? 234 THR A O   1 
ATOM   1630 C  CB  . THR A 1 229 ? -4.892  8.828   13.795  1.00 17.43 ? 234 THR A CB  1 
ATOM   1631 O  OG1 . THR A 1 229 ? -5.726  8.714   12.654  1.00 15.37 ? 234 THR A OG1 1 
ATOM   1632 C  CG2 . THR A 1 229 ? -5.215  10.109  14.530  1.00 17.39 ? 234 THR A CG2 1 
ATOM   1633 N  N   . PHE A 1 230 ? -2.292  8.353   15.383  1.00 19.24 ? 235 PHE A N   1 
ATOM   1634 C  CA  . PHE A 1 230 ? -1.487  8.674   16.555  1.00 20.11 ? 235 PHE A CA  1 
ATOM   1635 C  C   . PHE A 1 230 ? -0.021  8.797   16.159  1.00 20.57 ? 235 PHE A C   1 
ATOM   1636 O  O   . PHE A 1 230 ? 0.692   9.640   16.699  1.00 20.08 ? 235 PHE A O   1 
ATOM   1637 C  CB  . PHE A 1 230 ? -1.633  7.623   17.641  1.00 20.37 ? 235 PHE A CB  1 
ATOM   1638 C  CG  . PHE A 1 230 ? -2.994  7.601   18.271  1.00 21.90 ? 235 PHE A CG  1 
ATOM   1639 C  CD1 . PHE A 1 230 ? -3.729  8.776   18.429  1.00 22.49 ? 235 PHE A CD1 1 
ATOM   1640 C  CD2 . PHE A 1 230 ? -3.532  6.409   18.711  1.00 23.01 ? 235 PHE A CD2 1 
ATOM   1641 C  CE1 . PHE A 1 230 ? -5.006  8.749   19.009  1.00 22.72 ? 235 PHE A CE1 1 
ATOM   1642 C  CE2 . PHE A 1 230 ? -4.815  6.386   19.294  1.00 22.52 ? 235 PHE A CE2 1 
ATOM   1643 C  CZ  . PHE A 1 230 ? -5.532  7.561   19.440  1.00 21.66 ? 235 PHE A CZ  1 
ATOM   1644 N  N   . ASP A 1 231 ? 0.417   7.975   15.215  1.00 21.56 ? 236 ASP A N   1 
ATOM   1645 C  CA  . ASP A 1 231 ? 1.807   8.090   14.687  1.00 22.96 ? 236 ASP A CA  1 
ATOM   1646 C  C   . ASP A 1 231 ? 2.004   9.497   14.131  1.00 23.07 ? 236 ASP A C   1 
ATOM   1647 O  O   . ASP A 1 231 ? 3.065   10.102  14.315  1.00 23.36 ? 236 ASP A O   1 
ATOM   1648 C  CB  . ASP A 1 231 ? 2.091   7.070   13.571  1.00 23.08 ? 236 ASP A CB  1 
ATOM   1649 C  CG  . ASP A 1 231 ? 2.268   5.635   14.083  1.00 25.96 ? 236 ASP A CG  1 
ATOM   1650 O  OD1 . ASP A 1 231 ? 2.442   5.393   15.302  1.00 26.09 ? 236 ASP A OD1 1 
ATOM   1651 O  OD2 . ASP A 1 231 ? 2.214   4.727   13.227  1.00 28.12 ? 236 ASP A OD2 1 
ATOM   1652 N  N   . LEU A 1 232 ? 0.980   10.036  13.460  1.00 22.47 ? 237 LEU A N   1 
ATOM   1653 C  CA  . LEU A 1 232 ? 1.078   11.365  12.859  1.00 22.37 ? 237 LEU A CA  1 
ATOM   1654 C  C   . LEU A 1 232 ? 1.101   12.463  13.919  1.00 22.95 ? 237 LEU A C   1 
ATOM   1655 O  O   . LEU A 1 232 ? 1.898   13.425  13.823  1.00 22.17 ? 237 LEU A O   1 
ATOM   1656 C  CB  . LEU A 1 232 ? -0.053  11.629  11.849  1.00 23.18 ? 237 LEU A CB  1 
ATOM   1657 C  CG  . LEU A 1 232 ? 0.086   10.886  10.506  1.00 24.28 ? 237 LEU A CG  1 
ATOM   1658 C  CD1 . LEU A 1 232 ? -1.228  10.821  9.733   1.00 23.21 ? 237 LEU A CD1 1 
ATOM   1659 C  CD2 . LEU A 1 232 ? 1.223   11.462  9.614   1.00 24.21 ? 237 LEU A CD2 1 
ATOM   1660 N  N   . LEU A 1 233 ? 0.252   12.309  14.937  1.00 21.07 ? 238 LEU A N   1 
ATOM   1661 C  CA  . LEU A 1 233 ? 0.045   13.386  15.912  1.00 21.47 ? 238 LEU A CA  1 
ATOM   1662 C  C   . LEU A 1 233 ? 0.850   13.297  17.209  1.00 21.71 ? 238 LEU A C   1 
ATOM   1663 O  O   . LEU A 1 233 ? 1.354   14.304  17.694  1.00 22.53 ? 238 LEU A O   1 
ATOM   1664 C  CB  . LEU A 1 233 ? -1.452  13.498  16.251  1.00 20.24 ? 238 LEU A CB  1 
ATOM   1665 C  CG  . LEU A 1 233 ? -2.400  13.885  15.121  1.00 20.08 ? 238 LEU A CG  1 
ATOM   1666 C  CD1 . LEU A 1 233 ? -3.875  13.860  15.698  1.00 16.70 ? 238 LEU A CD1 1 
ATOM   1667 C  CD2 . LEU A 1 233 ? -2.070  15.261  14.488  1.00 21.59 ? 238 LEU A CD2 1 
ATOM   1668 N  N   . ILE A 1 234 ? 0.925   12.110  17.803  1.00 22.36 ? 239 ILE A N   1 
ATOM   1669 C  CA  . ILE A 1 234 ? 1.657   11.919  19.071  1.00 23.32 ? 239 ILE A CA  1 
ATOM   1670 C  C   . ILE A 1 234 ? 2.826   10.929  18.928  1.00 23.48 ? 239 ILE A C   1 
ATOM   1671 O  O   . ILE A 1 234 ? 3.298   10.383  19.919  1.00 23.67 ? 239 ILE A O   1 
ATOM   1672 C  CB  . ILE A 1 234 ? 0.732   11.494  20.237  1.00 22.94 ? 239 ILE A CB  1 
ATOM   1673 C  CG1 . ILE A 1 234 ? -0.120  10.267  19.847  1.00 24.19 ? 239 ILE A CG1 1 
ATOM   1674 C  CG2 . ILE A 1 234 ? -0.133  12.682  20.663  1.00 24.28 ? 239 ILE A CG2 1 
ATOM   1675 C  CD1 . ILE A 1 234 ? -0.918  9.608   21.012  1.00 22.01 ? 239 ILE A CD1 1 
ATOM   1676 N  N   . GLY A 1 235 ? 3.268   10.696  17.694  1.00 23.96 ? 240 GLY A N   1 
ATOM   1677 C  CA  . GLY A 1 235 ? 4.383   9.775   17.430  1.00 26.22 ? 240 GLY A CA  1 
ATOM   1678 C  C   . GLY A 1 235 ? 5.716   10.290  17.974  1.00 27.54 ? 240 GLY A C   1 
ATOM   1679 O  O   . GLY A 1 235 ? 6.550   9.496   18.402  1.00 27.45 ? 240 GLY A O   1 
ATOM   1680 N  N   . LYS A 1 236 ? 5.894   11.613  17.950  1.00 28.64 ? 241 LYS A N   1 
ATOM   1681 C  CA  . LYS A 1 236 ? 7.162   12.270  18.359  1.00 30.53 ? 241 LYS A CA  1 
ATOM   1682 C  C   . LYS A 1 236 ? 7.208   12.596  19.838  1.00 31.01 ? 241 LYS A C   1 
ATOM   1683 O  O   . LYS A 1 236 ? 8.262   12.533  20.466  1.00 31.53 ? 241 LYS A O   1 
ATOM   1684 C  CB  . LYS A 1 236 ? 7.342   13.589  17.618  1.00 29.99 ? 241 LYS A CB  1 
ATOM   1685 C  CG  . LYS A 1 236 ? 7.827   13.489  16.191  1.00 32.32 ? 241 LYS A CG  1 
ATOM   1686 C  CD  . LYS A 1 236 ? 8.606   14.785  15.866  1.00 35.98 ? 241 LYS A CD  1 
ATOM   1687 C  CE  . LYS A 1 236 ? 8.187   15.427  14.577  1.00 38.10 ? 241 LYS A CE  1 
ATOM   1688 N  NZ  . LYS A 1 236 ? 8.101   14.437  13.448  1.00 40.96 ? 241 LYS A NZ  1 
ATOM   1689 N  N   . ARG A 1 237 ? 6.060   12.989  20.380  1.00 30.76 ? 242 ARG A N   1 
ATOM   1690 C  CA  . ARG A 1 237 ? 5.973   13.421  21.750  1.00 30.50 ? 242 ARG A CA  1 
ATOM   1691 C  C   . ARG A 1 237 ? 4.509   13.363  22.195  1.00 30.87 ? 242 ARG A C   1 
ATOM   1692 O  O   . ARG A 1 237 ? 3.567   13.499  21.377  1.00 30.15 ? 242 ARG A O   1 
ATOM   1693 C  CB  . ARG A 1 237 ? 6.571   14.835  21.905  1.00 30.92 ? 242 ARG A CB  1 
ATOM   1694 C  CG  . ARG A 1 237 ? 5.891   15.869  21.047  1.00 31.29 ? 242 ARG A CG  1 
ATOM   1695 C  CD  . ARG A 1 237 ? 6.515   17.256  21.116  1.00 30.98 ? 242 ARG A CD  1 
ATOM   1696 N  NE  . ARG A 1 237 ? 5.679   18.191  20.351  1.00 32.24 ? 242 ARG A NE  1 
ATOM   1697 C  CZ  . ARG A 1 237 ? 5.661   18.292  19.018  1.00 30.56 ? 242 ARG A CZ  1 
ATOM   1698 N  NH1 . ARG A 1 237 ? 6.442   17.529  18.271  1.00 30.67 ? 242 ARG A NH1 1 
ATOM   1699 N  NH2 . ARG A 1 237 ? 4.876   19.178  18.429  1.00 30.10 ? 242 ARG A NH2 1 
ATOM   1700 N  N   . GLN A 1 238 ? 4.339   13.133  23.491  1.00 30.78 ? 243 GLN A N   1 
ATOM   1701 C  CA  . GLN A 1 238 ? 3.048   13.186  24.130  1.00 30.59 ? 243 GLN A CA  1 
ATOM   1702 C  C   . GLN A 1 238 ? 2.560   14.613  23.991  1.00 30.06 ? 243 GLN A C   1 
ATOM   1703 O  O   . GLN A 1 238 ? 3.328   15.567  24.201  1.00 30.70 ? 243 GLN A O   1 
ATOM   1704 C  CB  . GLN A 1 238 ? 3.157   12.775  25.589  1.00 30.62 ? 243 GLN A CB  1 
ATOM   1705 C  CG  . GLN A 1 238 ? 3.406   11.293  25.796  1.00 33.82 ? 243 GLN A CG  1 
ATOM   1706 C  CD  . GLN A 1 238 ? 3.644   10.912  27.258  1.00 39.51 ? 243 GLN A CD  1 
ATOM   1707 O  OE1 . GLN A 1 238 ? 3.236   11.616  28.192  1.00 41.53 ? 243 GLN A OE1 1 
ATOM   1708 N  NE2 . GLN A 1 238 ? 4.323   9.781   27.462  1.00 42.65 ? 243 GLN A NE2 1 
ATOM   1709 N  N   . ARG A 1 239 ? 1.301   14.749  23.594  1.00 28.37 ? 244 ARG A N   1 
ATOM   1710 C  CA  . ARG A 1 239 ? 0.654   16.039  23.397  1.00 26.11 ? 244 ARG A CA  1 
ATOM   1711 C  C   . ARG A 1 239 ? -0.800  15.911  23.843  1.00 25.54 ? 244 ARG A C   1 
ATOM   1712 O  O   . ARG A 1 239 ? -1.400  14.852  23.643  1.00 25.14 ? 244 ARG A O   1 
ATOM   1713 C  CB  . ARG A 1 239 ? 0.638   16.398  21.920  1.00 26.10 ? 244 ARG A CB  1 
ATOM   1714 C  CG  . ARG A 1 239 ? 1.988   16.600  21.274  1.00 26.12 ? 244 ARG A CG  1 
ATOM   1715 C  CD  . ARG A 1 239 ? 1.766   16.767  19.800  1.00 25.37 ? 244 ARG A CD  1 
ATOM   1716 N  NE  . ARG A 1 239 ? 1.444   18.135  19.381  1.00 22.46 ? 244 ARG A NE  1 
ATOM   1717 C  CZ  . ARG A 1 239 ? 1.312   18.472  18.108  1.00 21.00 ? 244 ARG A CZ  1 
ATOM   1718 N  NH1 . ARG A 1 239 ? 1.449   17.532  17.189  1.00 21.72 ? 244 ARG A NH1 1 
ATOM   1719 N  NH2 . ARG A 1 239 ? 1.054   19.727  17.745  1.00 20.12 ? 244 ARG A NH2 1 
ATOM   1720 N  N   . PRO A 1 240 ? -1.381  16.998  24.391  1.00 23.59 ? 245 PRO A N   1 
ATOM   1721 C  CA  . PRO A 1 240 ? -2.809  17.055  24.731  1.00 22.26 ? 245 PRO A CA  1 
ATOM   1722 C  C   . PRO A 1 240 ? -3.673  16.814  23.487  1.00 21.54 ? 245 PRO A C   1 
ATOM   1723 O  O   . PRO A 1 240 ? -3.448  17.427  22.422  1.00 20.64 ? 245 PRO A O   1 
ATOM   1724 C  CB  . PRO A 1 240 ? -2.996  18.491  25.253  1.00 22.43 ? 245 PRO A CB  1 
ATOM   1725 C  CG  . PRO A 1 240 ? -1.534  18.954  25.627  1.00 22.69 ? 245 PRO A CG  1 
ATOM   1726 C  CD  . PRO A 1 240 ? -0.679  18.279  24.641  1.00 23.45 ? 245 PRO A CD  1 
ATOM   1727 N  N   . ILE A 1 241 ? -4.657  15.925  23.612  1.00 20.54 ? 246 ILE A N   1 
ATOM   1728 C  CA  . ILE A 1 241 ? -5.512  15.634  22.477  1.00 18.59 ? 246 ILE A CA  1 
ATOM   1729 C  C   . ILE A 1 241 ? -6.850  16.391  22.574  1.00 18.13 ? 246 ILE A C   1 
ATOM   1730 O  O   . ILE A 1 241 ? -7.553  16.356  23.599  1.00 17.66 ? 246 ILE A O   1 
ATOM   1731 C  CB  . ILE A 1 241 ? -5.750  14.108  22.272  1.00 17.83 ? 246 ILE A CB  1 
ATOM   1732 C  CG1 . ILE A 1 241 ? -4.434  13.385  21.893  1.00 17.29 ? 246 ILE A CG1 1 
ATOM   1733 C  CG2 . ILE A 1 241 ? -6.792  13.880  21.171  1.00 16.83 ? 246 ILE A CG2 1 
ATOM   1734 C  CD1 . ILE A 1 241 ? -4.532  11.798  21.985  1.00 16.56 ? 246 ILE A CD1 1 
ATOM   1735 N  N   . HIS A 1 242 ? -7.197  17.038  21.478  1.00 17.16 ? 247 HIS A N   1 
ATOM   1736 C  CA  . HIS A 1 242 ? -8.525  17.593  21.337  1.00 16.84 ? 247 HIS A CA  1 
ATOM   1737 C  C   . HIS A 1 242 ? -9.360  16.736  20.371  1.00 16.22 ? 247 HIS A C   1 
ATOM   1738 O  O   . HIS A 1 242 ? -9.060  16.712  19.168  1.00 17.52 ? 247 HIS A O   1 
ATOM   1739 C  CB  . HIS A 1 242 ? -8.425  19.018  20.766  1.00 16.94 ? 247 HIS A CB  1 
ATOM   1740 C  CG  . HIS A 1 242 ? -9.721  19.765  20.843  1.00 17.80 ? 247 HIS A CG  1 
ATOM   1741 N  ND1 . HIS A 1 242 ? -9.943  20.779  21.752  1.00 19.10 ? 247 HIS A ND1 1 
ATOM   1742 C  CD2 . HIS A 1 242 ? -10.888 19.604  20.165  1.00 18.24 ? 247 HIS A CD2 1 
ATOM   1743 C  CE1 . HIS A 1 242 ? -11.185 21.221  21.623  1.00 16.71 ? 247 HIS A CE1 1 
ATOM   1744 N  NE2 . HIS A 1 242 ? -11.773 20.535  20.655  1.00 17.42 ? 247 HIS A NE2 1 
ATOM   1745 N  N   . LEU A 1 243 ? -10.404 16.063  20.867  1.00 15.22 ? 248 LEU A N   1 
ATOM   1746 C  CA  . LEU A 1 243 ? -11.245 15.240  20.021  1.00 14.31 ? 248 LEU A CA  1 
ATOM   1747 C  C   . LEU A 1 243 ? -12.465 16.027  19.615  1.00 14.34 ? 248 LEU A C   1 
ATOM   1748 O  O   . LEU A 1 243 ? -13.333 16.262  20.459  1.00 14.32 ? 248 LEU A O   1 
ATOM   1749 C  CB  . LEU A 1 243 ? -11.710 13.976  20.767  1.00 13.67 ? 248 LEU A CB  1 
ATOM   1750 C  CG  . LEU A 1 243 ? -12.664 13.022  20.003  1.00 12.91 ? 248 LEU A CG  1 
ATOM   1751 C  CD1 . LEU A 1 243 ? -12.026 12.647  18.645  1.00 16.32 ? 248 LEU A CD1 1 
ATOM   1752 C  CD2 . LEU A 1 243 ? -12.880 11.792  20.854  1.00 13.63 ? 248 LEU A CD2 1 
ATOM   1753 N  N   . SER A 1 244 ? -12.562 16.450  18.355  1.00 14.25 ? 249 SER A N   1 
ATOM   1754 C  CA  . SER A 1 244 ? -13.791 17.142  17.942  1.00 15.32 ? 249 SER A CA  1 
ATOM   1755 C  C   . SER A 1 244 ? -14.603 16.128  17.167  1.00 16.05 ? 249 SER A C   1 
ATOM   1756 O  O   . SER A 1 244 ? -14.209 15.732  16.052  1.00 15.69 ? 249 SER A O   1 
ATOM   1757 C  CB  . SER A 1 244 ? -13.487 18.378  17.061  1.00 16.07 ? 249 SER A CB  1 
ATOM   1758 O  OG  . SER A 1 244 ? -14.601 19.267  17.066  1.00 16.27 ? 249 SER A OG  1 
ATOM   1759 N  N   . PHE A 1 245 ? -15.768 15.754  17.712  1.00 15.03 ? 250 PHE A N   1 
ATOM   1760 C  CA  . PHE A 1 245 ? -16.493 14.602  17.208  1.00 14.35 ? 250 PHE A CA  1 
ATOM   1761 C  C   . PHE A 1 245 ? -17.918 15.016  16.795  1.00 14.63 ? 250 PHE A C   1 
ATOM   1762 O  O   . PHE A 1 245 ? -18.712 15.395  17.638  1.00 14.43 ? 250 PHE A O   1 
ATOM   1763 C  CB  . PHE A 1 245 ? -16.534 13.517  18.295  1.00 14.53 ? 250 PHE A CB  1 
ATOM   1764 C  CG  . PHE A 1 245 ? -16.847 12.119  17.755  1.00 16.05 ? 250 PHE A CG  1 
ATOM   1765 C  CD1 . PHE A 1 245 ? -18.051 11.863  17.102  1.00 16.61 ? 250 PHE A CD1 1 
ATOM   1766 C  CD2 . PHE A 1 245 ? -15.936 11.098  17.900  1.00 15.95 ? 250 PHE A CD2 1 
ATOM   1767 C  CE1 . PHE A 1 245 ? -18.352 10.584  16.582  1.00 19.31 ? 250 PHE A CE1 1 
ATOM   1768 C  CE2 . PHE A 1 245 ? -16.215 9.807   17.398  1.00 18.00 ? 250 PHE A CE2 1 
ATOM   1769 C  CZ  . PHE A 1 245 ? -17.421 9.553   16.744  1.00 18.91 ? 250 PHE A CZ  1 
ATOM   1770 N  N   . ASP A 1 246 ? -18.168 15.028  15.488  1.00 14.60 ? 251 ASP A N   1 
ATOM   1771 C  CA  . ASP A 1 246 ? -19.453 15.362  14.898  1.00 14.87 ? 251 ASP A CA  1 
ATOM   1772 C  C   . ASP A 1 246 ? -20.211 14.056  14.820  1.00 15.39 ? 251 ASP A C   1 
ATOM   1773 O  O   . ASP A 1 246 ? -19.724 13.057  14.260  1.00 15.38 ? 251 ASP A O   1 
ATOM   1774 C  CB  . ASP A 1 246 ? -19.222 15.987  13.510  1.00 13.81 ? 251 ASP A CB  1 
ATOM   1775 C  CG  . ASP A 1 246 ? -20.487 16.524  12.853  1.00 15.36 ? 251 ASP A CG  1 
ATOM   1776 O  OD1 . ASP A 1 246 ? -21.608 16.076  13.166  1.00 13.40 ? 251 ASP A OD1 1 
ATOM   1777 O  OD2 . ASP A 1 246 ? -20.336 17.386  11.967  1.00 17.69 ? 251 ASP A OD2 1 
ATOM   1778 N  N   . ILE A 1 247 ? -21.403 14.026  15.405  1.00 14.36 ? 252 ILE A N   1 
ATOM   1779 C  CA  . ILE A 1 247 ? -22.206 12.814  15.372  1.00 13.72 ? 252 ILE A CA  1 
ATOM   1780 C  C   . ILE A 1 247 ? -22.466 12.326  13.939  1.00 13.22 ? 252 ILE A C   1 
ATOM   1781 O  O   . ILE A 1 247 ? -22.696 11.121  13.719  1.00 13.22 ? 252 ILE A O   1 
ATOM   1782 C  CB  . ILE A 1 247 ? -23.561 13.011  16.152  1.00 13.91 ? 252 ILE A CB  1 
ATOM   1783 C  CG1 . ILE A 1 247 ? -24.143 11.670  16.634  1.00 14.88 ? 252 ILE A CG1 1 
ATOM   1784 C  CG2 . ILE A 1 247 ? -24.536 13.835  15.335  1.00 13.43 ? 252 ILE A CG2 1 
ATOM   1785 C  CD1 . ILE A 1 247 ? -23.279 10.972  17.717  1.00 15.95 ? 252 ILE A CD1 1 
ATOM   1786 N  N   . ASP A 1 248 ? -22.449 13.236  12.970  1.00 13.28 ? 253 ASP A N   1 
ATOM   1787 C  CA  . ASP A 1 248 ? -22.720 12.855  11.569  1.00 14.24 ? 253 ASP A CA  1 
ATOM   1788 C  C   . ASP A 1 248 ? -21.575 12.046  10.923  1.00 13.55 ? 253 ASP A C   1 
ATOM   1789 O  O   . ASP A 1 248 ? -21.699 11.597  9.780   1.00 14.09 ? 253 ASP A O   1 
ATOM   1790 C  CB  . ASP A 1 248 ? -23.192 14.064  10.679  1.00 14.22 ? 253 ASP A CB  1 
ATOM   1791 C  CG  . ASP A 1 248 ? -22.079 15.070  10.338  1.00 15.97 ? 253 ASP A CG  1 
ATOM   1792 O  OD1 . ASP A 1 248 ? -20.861 14.730  10.367  1.00 13.22 ? 253 ASP A OD1 1 
ATOM   1793 O  OD2 . ASP A 1 248 ? -22.425 16.266  10.058  1.00 15.17 ? 253 ASP A OD2 1 
ATOM   1794 N  N   . ALA A 1 249 ? -20.483 11.846  11.665  1.00 13.54 ? 254 ALA A N   1 
ATOM   1795 C  CA  . ALA A 1 249 ? -19.451 10.907  11.214  1.00 12.63 ? 254 ALA A CA  1 
ATOM   1796 C  C   . ALA A 1 249 ? -20.083 9.501   11.162  1.00 12.76 ? 254 ALA A C   1 
ATOM   1797 O  O   . ALA A 1 249 ? -19.705 8.697   10.307  1.00 12.24 ? 254 ALA A O   1 
ATOM   1798 C  CB  . ALA A 1 249 ? -18.263 10.927  12.153  1.00 12.13 ? 254 ALA A CB  1 
ATOM   1799 N  N   . PHE A 1 250 ? -21.053 9.211   12.041  1.00 12.13 ? 255 PHE A N   1 
ATOM   1800 C  CA  . PHE A 1 250 ? -21.721 7.890   12.026  1.00 12.84 ? 255 PHE A CA  1 
ATOM   1801 C  C   . PHE A 1 250 ? -22.694 7.784   10.847  1.00 14.62 ? 255 PHE A C   1 
ATOM   1802 O  O   . PHE A 1 250 ? -23.266 8.795   10.433  1.00 14.49 ? 255 PHE A O   1 
ATOM   1803 C  CB  . PHE A 1 250 ? -22.529 7.632   13.318  1.00 12.82 ? 255 PHE A CB  1 
ATOM   1804 C  CG  . PHE A 1 250 ? -21.684 7.327   14.538  1.00 14.02 ? 255 PHE A CG  1 
ATOM   1805 C  CD1 . PHE A 1 250 ? -21.120 6.060   14.715  1.00 15.04 ? 255 PHE A CD1 1 
ATOM   1806 C  CD2 . PHE A 1 250 ? -21.497 8.292   15.530  1.00 12.91 ? 255 PHE A CD2 1 
ATOM   1807 C  CE1 . PHE A 1 250 ? -20.359 5.749   15.887  1.00 16.11 ? 255 PHE A CE1 1 
ATOM   1808 C  CE2 . PHE A 1 250 ? -20.752 8.025   16.668  1.00 14.61 ? 255 PHE A CE2 1 
ATOM   1809 C  CZ  . PHE A 1 250 ? -20.177 6.755   16.873  1.00 17.17 ? 255 PHE A CZ  1 
ATOM   1810 N  N   . ASP A 1 251 ? -22.920 6.560   10.358  1.00 14.26 ? 256 ASP A N   1 
ATOM   1811 C  CA  . ASP A 1 251 ? -23.958 6.334   9.355   1.00 15.96 ? 256 ASP A CA  1 
ATOM   1812 C  C   . ASP A 1 251 ? -25.296 6.896   9.849   1.00 15.95 ? 256 ASP A C   1 
ATOM   1813 O  O   . ASP A 1 251 ? -25.614 6.767   11.030  1.00 14.54 ? 256 ASP A O   1 
ATOM   1814 C  CB  . ASP A 1 251 ? -24.145 4.849   9.063   1.00 15.71 ? 256 ASP A CB  1 
ATOM   1815 C  CG  . ASP A 1 251 ? -24.856 4.640   7.739   1.00 19.49 ? 256 ASP A CG  1 
ATOM   1816 O  OD1 . ASP A 1 251 ? -26.099 4.426   7.743   1.00 17.66 ? 256 ASP A OD1 1 
ATOM   1817 O  OD2 . ASP A 1 251 ? -24.171 4.792   6.699   1.00 20.05 ? 256 ASP A OD2 1 
ATOM   1818 N  N   . PRO A 1 252 ? -26.063 7.534   8.948   1.00 16.76 ? 257 PRO A N   1 
ATOM   1819 C  CA  . PRO A 1 252 ? -27.364 8.109   9.332   1.00 18.57 ? 257 PRO A CA  1 
ATOM   1820 C  C   . PRO A 1 252 ? -28.348 7.100   9.862   1.00 19.76 ? 257 PRO A C   1 
ATOM   1821 O  O   . PRO A 1 252 ? -29.233 7.498   10.594  1.00 20.97 ? 257 PRO A O   1 
ATOM   1822 C  CB  . PRO A 1 252 ? -27.894 8.724   8.033   1.00 18.76 ? 257 PRO A CB  1 
ATOM   1823 C  CG  . PRO A 1 252 ? -26.712 8.912   7.185   1.00 17.10 ? 257 PRO A CG  1 
ATOM   1824 C  CD  . PRO A 1 252 ? -25.719 7.855   7.558   1.00 16.77 ? 257 PRO A CD  1 
ATOM   1825 N  N   . THR A 1 253 ? -28.195 5.811   9.535   1.00 21.09 ? 258 THR A N   1 
ATOM   1826 C  CA  . THR A 1 253 ? -29.035 4.765   10.143  1.00 21.29 ? 258 THR A CA  1 
ATOM   1827 C  C   . THR A 1 253 ? -28.818 4.689   11.667  1.00 22.10 ? 258 THR A C   1 
ATOM   1828 O  O   . THR A 1 253 ? -29.730 4.305   12.412  1.00 21.76 ? 258 THR A O   1 
ATOM   1829 C  CB  . THR A 1 253 ? -28.790 3.373   9.521   1.00 22.33 ? 258 THR A CB  1 
ATOM   1830 O  OG1 . THR A 1 253 ? -27.414 2.975   9.706   1.00 23.45 ? 258 THR A OG1 1 
ATOM   1831 C  CG2 . THR A 1 253 ? -29.159 3.349   8.009   1.00 21.80 ? 258 THR A CG2 1 
ATOM   1832 N  N   . LEU A 1 254 ? -27.610 5.059   12.121  1.00 20.77 ? 259 LEU A N   1 
ATOM   1833 C  CA  . LEU A 1 254 ? -27.269 5.059   13.550  1.00 20.83 ? 259 LEU A CA  1 
ATOM   1834 C  C   . LEU A 1 254 ? -27.456 6.395   14.247  1.00 19.69 ? 259 LEU A C   1 
ATOM   1835 O  O   . LEU A 1 254 ? -27.794 6.448   15.434  1.00 21.17 ? 259 LEU A O   1 
ATOM   1836 C  CB  . LEU A 1 254 ? -25.822 4.635   13.768  1.00 21.19 ? 259 LEU A CB  1 
ATOM   1837 C  CG  . LEU A 1 254 ? -25.354 3.327   13.148  1.00 22.66 ? 259 LEU A CG  1 
ATOM   1838 C  CD1 . LEU A 1 254 ? -23.816 3.325   13.231  1.00 22.73 ? 259 LEU A CD1 1 
ATOM   1839 C  CD2 . LEU A 1 254 ? -25.979 2.120   13.854  1.00 25.20 ? 259 LEU A CD2 1 
ATOM   1840 N  N   . ALA A 1 255 ? -27.174 7.470   13.531  1.00 18.55 ? 260 ALA A N   1 
ATOM   1841 C  CA  . ALA A 1 255 ? -27.289 8.810   14.056  1.00 18.94 ? 260 ALA A CA  1 
ATOM   1842 C  C   . ALA A 1 255 ? -28.154 9.610   13.106  1.00 18.18 ? 260 ALA A C   1 
ATOM   1843 O  O   . ALA A 1 255 ? -27.654 10.480  12.405  1.00 17.35 ? 260 ALA A O   1 
ATOM   1844 C  CB  . ALA A 1 255 ? -25.885 9.503   14.220  1.00 18.20 ? 260 ALA A CB  1 
ATOM   1845 N  N   . PRO A 1 256 ? -29.464 9.317   13.085  1.00 18.69 ? 261 PRO A N   1 
ATOM   1846 C  CA  . PRO A 1 256 ? -30.293 10.051  12.129  1.00 19.53 ? 261 PRO A CA  1 
ATOM   1847 C  C   . PRO A 1 256 ? -30.546 11.516  12.538  1.00 19.87 ? 261 PRO A C   1 
ATOM   1848 O  O   . PRO A 1 256 ? -30.768 12.368  11.660  1.00 21.57 ? 261 PRO A O   1 
ATOM   1849 C  CB  . PRO A 1 256 ? -31.600 9.224   12.087  1.00 19.78 ? 261 PRO A CB  1 
ATOM   1850 C  CG  . PRO A 1 256 ? -31.638 8.494   13.393  1.00 20.00 ? 261 PRO A CG  1 
ATOM   1851 C  CD  . PRO A 1 256 ? -30.174 8.184   13.693  1.00 18.92 ? 261 PRO A CD  1 
ATOM   1852 N  N   . ALA A 1 257 ? -30.500 11.799  13.842  1.00 19.28 ? 262 ALA A N   1 
ATOM   1853 C  CA  . ALA A 1 257 ? -30.834 13.126  14.382  1.00 19.05 ? 262 ALA A CA  1 
ATOM   1854 C  C   . ALA A 1 257 ? -29.730 14.154  14.276  1.00 18.77 ? 262 ALA A C   1 
ATOM   1855 O  O   . ALA A 1 257 ? -29.121 14.528  15.281  1.00 18.37 ? 262 ALA A O   1 
ATOM   1856 C  CB  . ALA A 1 257 ? -31.327 13.014  15.818  1.00 19.07 ? 262 ALA A CB  1 
ATOM   1857 N  N   . THR A 1 258 ? -29.507 14.645  13.053  1.00 18.63 ? 263 THR A N   1 
ATOM   1858 C  CA  . THR A 1 258 ? -28.397 15.561  12.781  1.00 18.16 ? 263 THR A CA  1 
ATOM   1859 C  C   . THR A 1 258 ? -28.708 16.274  11.466  1.00 19.18 ? 263 THR A C   1 
ATOM   1860 O  O   . THR A 1 258 ? -29.464 15.747  10.635  1.00 20.59 ? 263 THR A O   1 
ATOM   1861 C  CB  . THR A 1 258 ? -27.047 14.807  12.700  1.00 17.82 ? 263 THR A CB  1 
ATOM   1862 O  OG1 . THR A 1 258 ? -25.974 15.760  12.738  1.00 14.76 ? 263 THR A OG1 1 
ATOM   1863 C  CG2 . THR A 1 258 ? -26.967 14.001  11.417  1.00 18.84 ? 263 THR A CG2 1 
ATOM   1864 N  N   . GLY A 1 259 ? -28.143 17.455  11.278  1.00 19.50 ? 264 GLY A N   1 
ATOM   1865 C  CA  . GLY A 1 259 ? -28.545 18.338  10.166  1.00 20.67 ? 264 GLY A CA  1 
ATOM   1866 C  C   . GLY A 1 259 ? -28.031 18.020  8.770   1.00 20.92 ? 264 GLY A C   1 
ATOM   1867 O  O   . GLY A 1 259 ? -28.716 18.288  7.788   1.00 21.00 ? 264 GLY A O   1 
ATOM   1868 N  N   . THR A 1 260 ? -26.819 17.479  8.667   1.00 20.00 ? 265 THR A N   1 
ATOM   1869 C  CA  . THR A 1 260 ? -26.256 17.179  7.349   1.00 21.50 ? 265 THR A CA  1 
ATOM   1870 C  C   . THR A 1 260 ? -25.823 15.701  7.268   1.00 20.14 ? 265 THR A C   1 
ATOM   1871 O  O   . THR A 1 260 ? -24.634 15.398  7.275   1.00 20.62 ? 265 THR A O   1 
ATOM   1872 C  CB  . THR A 1 260 ? -25.105 18.135  7.000   1.00 22.29 ? 265 THR A CB  1 
ATOM   1873 O  OG1 . THR A 1 260 ? -24.019 17.931  7.910   1.00 28.66 ? 265 THR A OG1 1 
ATOM   1874 C  CG2 . THR A 1 260 ? -25.528 19.586  7.116   1.00 22.55 ? 265 THR A CG2 1 
ATOM   1875 N  N   . PRO A 1 261 ? -26.798 14.777  7.250   1.00 19.64 ? 266 PRO A N   1 
ATOM   1876 C  CA  . PRO A 1 261 ? -26.481 13.350  7.303   1.00 18.74 ? 266 PRO A CA  1 
ATOM   1877 C  C   . PRO A 1 261 ? -25.976 12.880  5.948   1.00 18.68 ? 266 PRO A C   1 
ATOM   1878 O  O   . PRO A 1 261 ? -26.431 13.383  4.914   1.00 18.12 ? 266 PRO A O   1 
ATOM   1879 C  CB  . PRO A 1 261 ? -27.829 12.705  7.616   1.00 18.65 ? 266 PRO A CB  1 
ATOM   1880 C  CG  . PRO A 1 261 ? -28.813 13.640  7.032   1.00 19.35 ? 266 PRO A CG  1 
ATOM   1881 C  CD  . PRO A 1 261 ? -28.252 15.013  7.133   1.00 19.30 ? 266 PRO A CD  1 
ATOM   1882 N  N   . VAL A 1 262 ? -25.002 11.982  5.944   1.00 17.80 ? 267 VAL A N   1 
ATOM   1883 C  CA  . VAL A 1 262 ? -24.420 11.493  4.680   1.00 18.23 ? 267 VAL A CA  1 
ATOM   1884 C  C   . VAL A 1 262 ? -24.284 9.992   4.742   1.00 17.50 ? 267 VAL A C   1 
ATOM   1885 O  O   . VAL A 1 262 ? -23.674 9.468   5.666   1.00 17.80 ? 267 VAL A O   1 
ATOM   1886 C  CB  . VAL A 1 262 ? -23.032 12.123  4.384   1.00 17.62 ? 267 VAL A CB  1 
ATOM   1887 C  CG1 . VAL A 1 262 ? -22.536 11.687  2.985   1.00 18.86 ? 267 VAL A CG1 1 
ATOM   1888 C  CG2 . VAL A 1 262 ? -23.135 13.635  4.488   1.00 18.72 ? 267 VAL A CG2 1 
ATOM   1889 N  N   . VAL A 1 263 ? -24.858 9.302   3.754   1.00 17.14 ? 268 VAL A N   1 
ATOM   1890 C  CA  . VAL A 1 263 ? -24.911 7.836   3.774   1.00 17.15 ? 268 VAL A CA  1 
ATOM   1891 C  C   . VAL A 1 263 ? -23.480 7.290   3.756   1.00 15.75 ? 268 VAL A C   1 
ATOM   1892 O  O   . VAL A 1 263 ? -22.573 7.944   3.229   1.00 15.68 ? 268 VAL A O   1 
ATOM   1893 C  CB  . VAL A 1 263 ? -25.743 7.291   2.562   1.00 17.32 ? 268 VAL A CB  1 
ATOM   1894 C  CG1 . VAL A 1 263 ? -25.187 7.839   1.255   1.00 18.62 ? 268 VAL A CG1 1 
ATOM   1895 C  CG2 . VAL A 1 263 ? -25.762 5.750   2.513   1.00 22.29 ? 268 VAL A CG2 1 
ATOM   1896 N  N   . GLY A 1 264 ? -23.294 6.098   4.310   1.00 15.57 ? 269 GLY A N   1 
ATOM   1897 C  CA  . GLY A 1 264 ? -22.024 5.372   4.189   1.00 13.74 ? 269 GLY A CA  1 
ATOM   1898 C  C   . GLY A 1 264 ? -21.024 5.783   5.252   1.00 13.64 ? 269 GLY A C   1 
ATOM   1899 O  O   . GLY A 1 264 ? -19.859 5.915   4.972   1.00 13.70 ? 269 GLY A O   1 
ATOM   1900 N  N   . GLY A 1 265 ? -21.489 5.941   6.490   1.00 13.81 ? 270 GLY A N   1 
ATOM   1901 C  CA  . GLY A 1 265 ? -20.614 6.383   7.563   1.00 13.49 ? 270 GLY A CA  1 
ATOM   1902 C  C   . GLY A 1 265 ? -20.032 5.336   8.476   1.00 12.72 ? 270 GLY A C   1 
ATOM   1903 O  O   . GLY A 1 265 ? -20.078 4.143   8.202   1.00 12.84 ? 270 GLY A O   1 
ATOM   1904 N  N   . LEU A 1 266 ? -19.436 5.807   9.580   1.00 12.21 ? 271 LEU A N   1 
ATOM   1905 C  CA  . LEU A 1 266 ? -18.855 4.899   10.586  1.00 11.54 ? 271 LEU A CA  1 
ATOM   1906 C  C   . LEU A 1 266 ? -19.932 3.983   11.124  1.00 12.23 ? 271 LEU A C   1 
ATOM   1907 O  O   . LEU A 1 266 ? -21.073 4.428   11.303  1.00 12.13 ? 271 LEU A O   1 
ATOM   1908 C  CB  . LEU A 1 266 ? -18.336 5.689   11.783  1.00 10.51 ? 271 LEU A CB  1 
ATOM   1909 C  CG  . LEU A 1 266 ? -17.233 6.713   11.474  1.00 11.62 ? 271 LEU A CG  1 
ATOM   1910 C  CD1 . LEU A 1 266 ? -16.924 7.372   12.791  1.00 13.39 ? 271 LEU A CD1 1 
ATOM   1911 C  CD2 . LEU A 1 266 ? -15.965 5.982   10.970  1.00 12.78 ? 271 LEU A CD2 1 
ATOM   1912 N  N   . THR A 1 267 ? -19.572 2.729   11.389  1.00 12.04 ? 272 THR A N   1 
ATOM   1913 C  CA  . THR A 1 267 ? -20.455 1.846   12.198  1.00 12.53 ? 272 THR A CA  1 
ATOM   1914 C  C   . THR A 1 267 ? -20.366 2.214   13.677  1.00 12.57 ? 272 THR A C   1 
ATOM   1915 O  O   . THR A 1 267 ? -19.476 2.976   14.080  1.00 12.65 ? 272 THR A O   1 
ATOM   1916 C  CB  . THR A 1 267 ? -20.126 0.352   12.015  1.00 13.33 ? 272 THR A CB  1 
ATOM   1917 O  OG1 . THR A 1 267 ? -18.853 0.054   12.633  1.00 10.15 ? 272 THR A OG1 1 
ATOM   1918 C  CG2 . THR A 1 267 ? -20.063 -0.036  10.504  1.00 13.10 ? 272 THR A CG2 1 
ATOM   1919 N  N   . TYR A 1 268 ? -21.303 1.701   14.490  1.00 12.54 ? 273 TYR A N   1 
ATOM   1920 C  CA  . TYR A 1 268 ? -21.210 1.830   15.955  1.00 11.92 ? 273 TYR A CA  1 
ATOM   1921 C  C   . TYR A 1 268 ? -19.845 1.366   16.456  1.00 12.72 ? 273 TYR A C   1 
ATOM   1922 O  O   . TYR A 1 268 ? -19.204 2.035   17.282  1.00 10.90 ? 273 TYR A O   1 
ATOM   1923 C  CB  . TYR A 1 268 ? -22.322 1.006   16.636  1.00 13.56 ? 273 TYR A CB  1 
ATOM   1924 C  CG  . TYR A 1 268 ? -22.320 1.141   18.119  1.00 14.75 ? 273 TYR A CG  1 
ATOM   1925 C  CD1 . TYR A 1 268 ? -22.931 2.248   18.748  1.00 16.32 ? 273 TYR A CD1 1 
ATOM   1926 C  CD2 . TYR A 1 268 ? -21.654 0.185   18.914  1.00 15.06 ? 273 TYR A CD2 1 
ATOM   1927 C  CE1 . TYR A 1 268 ? -22.892 2.383   20.147  1.00 15.94 ? 273 TYR A CE1 1 
ATOM   1928 C  CE2 . TYR A 1 268 ? -21.605 0.306   20.287  1.00 15.46 ? 273 TYR A CE2 1 
ATOM   1929 C  CZ  . TYR A 1 268 ? -22.226 1.417   20.899  1.00 16.78 ? 273 TYR A CZ  1 
ATOM   1930 O  OH  . TYR A 1 268 ? -22.151 1.526   22.272  1.00 17.14 ? 273 TYR A OH  1 
ATOM   1931 N  N   . ARG A 1 269 ? -19.425 0.194   15.979  1.00 10.68 ? 274 ARG A N   1 
ATOM   1932 C  CA  . ARG A 1 269 ? -18.188 -0.419  16.476  1.00 11.88 ? 274 ARG A CA  1 
ATOM   1933 C  C   . ARG A 1 269 ? -17.007 0.423   16.101  1.00 10.84 ? 274 ARG A C   1 
ATOM   1934 O  O   . ARG A 1 269 ? -16.097 0.564   16.916  1.00 13.33 ? 274 ARG A O   1 
ATOM   1935 C  CB  . ARG A 1 269 ? -18.021 -1.836  15.881  1.00 10.86 ? 274 ARG A CB  1 
ATOM   1936 C  CG  . ARG A 1 269 ? -18.959 -2.868  16.534  1.00 11.96 ? 274 ARG A CG  1 
ATOM   1937 C  CD  . ARG A 1 269 ? -19.251 -4.063  15.609  1.00 12.16 ? 274 ARG A CD  1 
ATOM   1938 N  NE  . ARG A 1 269 ? -18.047 -4.816  15.238  1.00 12.74 ? 274 ARG A NE  1 
ATOM   1939 C  CZ  . ARG A 1 269 ? -18.059 -5.926  14.508  1.00 12.19 ? 274 ARG A CZ  1 
ATOM   1940 N  NH1 . ARG A 1 269 ? -19.224 -6.445  14.118  1.00 10.94 ? 274 ARG A NH1 1 
ATOM   1941 N  NH2 . ARG A 1 269 ? -16.897 -6.549  14.210  1.00 10.60 ? 274 ARG A NH2 1 
ATOM   1942 N  N   . GLU A 1 270 ? -16.993 0.978   14.878  1.00 11.74 ? 275 GLU A N   1 
ATOM   1943 C  CA  . GLU A 1 270 ? -15.846 1.849   14.486  1.00 11.53 ? 275 GLU A CA  1 
ATOM   1944 C  C   . GLU A 1 270 ? -15.797 3.102   15.359  1.00 11.93 ? 275 GLU A C   1 
ATOM   1945 O  O   . GLU A 1 270 ? -14.714 3.519   15.786  1.00 11.07 ? 275 GLU A O   1 
ATOM   1946 C  CB  . GLU A 1 270 ? -15.892 2.245   12.993  1.00 10.80 ? 275 GLU A CB  1 
ATOM   1947 C  CG  . GLU A 1 270 ? -15.518 1.100   12.055  1.00 11.94 ? 275 GLU A CG  1 
ATOM   1948 C  CD  . GLU A 1 270 ? -15.975 1.333   10.609  1.00 14.37 ? 275 GLU A CD  1 
ATOM   1949 O  OE1 . GLU A 1 270 ? -16.952 2.088   10.405  1.00 10.18 ? 275 GLU A OE1 1 
ATOM   1950 O  OE2 . GLU A 1 270 ? -15.366 0.744   9.680   1.00 14.21 ? 275 GLU A OE2 1 
ATOM   1951 N  N   . GLY A 1 271 ? -16.949 3.737   15.585  1.00 10.43 ? 276 GLY A N   1 
ATOM   1952 C  CA  . GLY A 1 271 ? -16.989 4.918   16.441  1.00 12.12 ? 276 GLY A CA  1 
ATOM   1953 C  C   . GLY A 1 271 ? -16.513 4.642   17.861  1.00 11.95 ? 276 GLY A C   1 
ATOM   1954 O  O   . GLY A 1 271 ? -15.797 5.455   18.455  1.00 11.72 ? 276 GLY A O   1 
ATOM   1955 N  N   . MET A 1 272 ? -16.904 3.498   18.421  1.00 12.12 ? 277 MET A N   1 
ATOM   1956 C  CA  . MET A 1 272 ? -16.523 3.184   19.797  1.00 12.63 ? 277 MET A CA  1 
ATOM   1957 C  C   . MET A 1 272 ? -15.033 2.896   19.794  1.00 13.35 ? 277 MET A C   1 
ATOM   1958 O  O   . MET A 1 272 ? -14.317 3.231   20.756  1.00 11.92 ? 277 MET A O   1 
ATOM   1959 C  CB  . MET A 1 272 ? -17.288 1.952   20.339  1.00 12.69 ? 277 MET A CB  1 
ATOM   1960 C  CG  . MET A 1 272 ? -18.813 2.170   20.551  1.00 15.25 ? 277 MET A CG  1 
ATOM   1961 S  SD  . MET A 1 272 ? -19.059 3.573   21.632  1.00 18.50 ? 277 MET A SD  1 
ATOM   1962 C  CE  . MET A 1 272 ? -19.567 4.841   20.494  1.00 15.12 ? 277 MET A CE  1 
ATOM   1963 N  N   . TYR A 1 273 ? -14.564 2.286   18.710  1.00 13.70 ? 278 TYR A N   1 
ATOM   1964 C  CA  . TYR A 1 273 ? -13.126 1.952   18.597  1.00 13.27 ? 278 TYR A CA  1 
ATOM   1965 C  C   . TYR A 1 273 ? -12.257 3.226   18.596  1.00 14.13 ? 278 TYR A C   1 
ATOM   1966 O  O   . TYR A 1 273 ? -11.194 3.309   19.271  1.00 14.31 ? 278 TYR A O   1 
ATOM   1967 C  CB  . TYR A 1 273 ? -12.846 1.064   17.374  1.00 13.94 ? 278 TYR A CB  1 
ATOM   1968 C  CG  . TYR A 1 273 ? -11.429 0.537   17.436  1.00 14.59 ? 278 TYR A CG  1 
ATOM   1969 C  CD1 . TYR A 1 273 ? -11.131 -0.634  18.122  1.00 15.12 ? 278 TYR A CD1 1 
ATOM   1970 C  CD2 . TYR A 1 273 ? -10.373 1.289   16.915  1.00 15.35 ? 278 TYR A CD2 1 
ATOM   1971 C  CE1 . TYR A 1 273 ? -9.775  -1.087  18.241  1.00 17.81 ? 278 TYR A CE1 1 
ATOM   1972 C  CE2 . TYR A 1 273 ? -9.077  0.855   17.009  1.00 16.51 ? 278 TYR A CE2 1 
ATOM   1973 C  CZ  . TYR A 1 273 ? -8.781  -0.325  17.680  1.00 16.54 ? 278 TYR A CZ  1 
ATOM   1974 O  OH  . TYR A 1 273 ? -7.463  -0.701  17.734  1.00 22.01 ? 278 TYR A OH  1 
ATOM   1975 N  N   . ILE A 1 274 ? -12.699 4.230   17.842  1.00 12.95 ? 279 ILE A N   1 
ATOM   1976 C  CA  . ILE A 1 274 ? -12.012 5.511   17.851  1.00 12.99 ? 279 ILE A CA  1 
ATOM   1977 C  C   . ILE A 1 274 ? -11.893 6.069   19.275  1.00 13.47 ? 279 ILE A C   1 
ATOM   1978 O  O   . ILE A 1 274 ? -10.808 6.454   19.720  1.00 13.44 ? 279 ILE A O   1 
ATOM   1979 C  CB  . ILE A 1 274 ? -12.737 6.511   16.956  1.00 12.41 ? 279 ILE A CB  1 
ATOM   1980 C  CG1 . ILE A 1 274 ? -12.698 6.041   15.492  1.00 12.07 ? 279 ILE A CG1 1 
ATOM   1981 C  CG2 . ILE A 1 274 ? -12.168 7.955   17.156  1.00 13.56 ? 279 ILE A CG2 1 
ATOM   1982 C  CD1 . ILE A 1 274 ? -13.596 6.945   14.562  1.00 13.48 ? 279 ILE A CD1 1 
ATOM   1983 N  N   . ALA A 1 275 ? -13.009 6.098   19.986  1.00 12.50 ? 280 ALA A N   1 
ATOM   1984 C  CA  . ALA A 1 275 ? -13.053 6.651   21.333  1.00 14.11 ? 280 ALA A CA  1 
ATOM   1985 C  C   . ALA A 1 275 ? -12.219 5.859   22.314  1.00 14.59 ? 280 ALA A C   1 
ATOM   1986 O  O   . ALA A 1 275 ? -11.555 6.459   23.158  1.00 14.44 ? 280 ALA A O   1 
ATOM   1987 C  CB  . ALA A 1 275 ? -14.544 6.714   21.845  1.00 12.85 ? 280 ALA A CB  1 
ATOM   1988 N  N   . GLU A 1 276 ? -12.264 4.522   22.219  1.00 13.58 ? 281 GLU A N   1 
ATOM   1989 C  CA  . GLU A 1 276 ? -11.471 3.653   23.118  1.00 14.56 ? 281 GLU A CA  1 
ATOM   1990 C  C   . GLU A 1 276 ? -9.975  3.917   22.933  1.00 14.67 ? 281 GLU A C   1 
ATOM   1991 O  O   . GLU A 1 276 ? -9.205  3.970   23.917  1.00 15.16 ? 281 GLU A O   1 
ATOM   1992 C  CB  . GLU A 1 276 ? -11.743 2.167   22.836  1.00 13.97 ? 281 GLU A CB  1 
ATOM   1993 C  CG  . GLU A 1 276 ? -13.116 1.704   23.336  1.00 15.11 ? 281 GLU A CG  1 
ATOM   1994 C  CD  . GLU A 1 276 ? -13.595 0.385   22.725  1.00 16.30 ? 281 GLU A CD  1 
ATOM   1995 O  OE1 . GLU A 1 276 ? -12.905 -0.148  21.834  1.00 20.31 ? 281 GLU A OE1 1 
ATOM   1996 O  OE2 . GLU A 1 276 ? -14.723 -0.059  23.093  1.00 17.06 ? 281 GLU A OE2 1 
ATOM   1997 N  N   . GLU A 1 277 ? -9.565  4.070   21.695  1.00 13.61 ? 282 GLU A N   1 
ATOM   1998 C  CA  . GLU A 1 277 ? -8.134  4.289   21.417  1.00 15.35 ? 282 GLU A CA  1 
ATOM   1999 C  C   . GLU A 1 277 ? -7.709  5.675   21.902  1.00 16.19 ? 282 GLU A C   1 
ATOM   2000 O  O   . GLU A 1 277 ? -6.585  5.855   22.413  1.00 16.11 ? 282 GLU A O   1 
ATOM   2001 C  CB  . GLU A 1 277 ? -7.825  4.110   19.930  1.00 15.01 ? 282 GLU A CB  1 
ATOM   2002 C  CG  . GLU A 1 277 ? -7.949  2.647   19.505  1.00 16.97 ? 282 GLU A CG  1 
ATOM   2003 C  CD  . GLU A 1 277 ? -7.043  1.772   20.384  1.00 21.32 ? 282 GLU A CD  1 
ATOM   2004 O  OE1 . GLU A 1 277 ? -5.812  2.021   20.400  1.00 22.15 ? 282 GLU A OE1 1 
ATOM   2005 O  OE2 . GLU A 1 277 ? -7.566  0.903   21.098  1.00 20.63 ? 282 GLU A OE2 1 
ATOM   2006 N  N   . ILE A 1 278 ? -8.595  6.649   21.737  1.00 15.71 ? 283 ILE A N   1 
ATOM   2007 C  CA  . ILE A 1 278 ? -8.373  7.998   22.303  1.00 16.72 ? 283 ILE A CA  1 
ATOM   2008 C  C   . ILE A 1 278 ? -8.180  7.885   23.820  1.00 17.43 ? 283 ILE A C   1 
ATOM   2009 O  O   . ILE A 1 278 ? -7.193  8.427   24.368  1.00 16.94 ? 283 ILE A O   1 
ATOM   2010 C  CB  . ILE A 1 278 ? -9.513  8.976   21.940  1.00 17.91 ? 283 ILE A CB  1 
ATOM   2011 C  CG1 . ILE A 1 278 ? -9.465  9.285   20.426  1.00 19.75 ? 283 ILE A CG1 1 
ATOM   2012 C  CG2 . ILE A 1 278 ? -9.472  10.285  22.822  1.00 18.01 ? 283 ILE A CG2 1 
ATOM   2013 C  CD1 . ILE A 1 278 ? -8.572  10.407  20.046  1.00 23.36 ? 283 ILE A CD1 1 
ATOM   2014 N  N   . HIS A 1 279 ? -9.094  7.182   24.491  1.00 16.73 ? 284 HIS A N   1 
ATOM   2015 C  CA  . HIS A 1 279 ? -8.933  6.960   25.934  1.00 18.01 ? 284 HIS A CA  1 
ATOM   2016 C  C   . HIS A 1 279 ? -7.601  6.281   26.284  1.00 18.78 ? 284 HIS A C   1 
ATOM   2017 O  O   . HIS A 1 279 ? -6.926  6.715   27.227  1.00 18.60 ? 284 HIS A O   1 
ATOM   2018 C  CB  . HIS A 1 279 ? -10.106 6.183   26.520  1.00 17.51 ? 284 HIS A CB  1 
ATOM   2019 C  CG  . HIS A 1 279 ? -9.832  5.650   27.890  1.00 20.45 ? 284 HIS A CG  1 
ATOM   2020 N  ND1 . HIS A 1 279 ? -9.861  6.448   29.018  1.00 20.78 ? 284 HIS A ND1 1 
ATOM   2021 C  CD2 . HIS A 1 279 ? -9.422  4.429   28.303  1.00 19.34 ? 284 HIS A CD2 1 
ATOM   2022 C  CE1 . HIS A 1 279 ? -9.553  5.721   30.078  1.00 18.48 ? 284 HIS A CE1 1 
ATOM   2023 N  NE2 . HIS A 1 279 ? -9.292  4.490   29.675  1.00 21.82 ? 284 HIS A NE2 1 
ATOM   2024 N  N   . ASN A 1 280 ? -7.212  5.256   25.516  1.00 18.67 ? 285 ASN A N   1 
ATOM   2025 C  CA  . ASN A 1 280 ? -6.015  4.460   25.826  1.00 20.23 ? 285 ASN A CA  1 
ATOM   2026 C  C   . ASN A 1 280 ? -4.718  5.262   25.749  1.00 20.37 ? 285 ASN A C   1 
ATOM   2027 O  O   . ASN A 1 280 ? -3.713  4.846   26.327  1.00 21.16 ? 285 ASN A O   1 
ATOM   2028 C  CB  . ASN A 1 280 ? -5.920  3.223   24.912  1.00 20.75 ? 285 ASN A CB  1 
ATOM   2029 C  CG  . ASN A 1 280 ? -6.939  2.150   25.259  1.00 22.27 ? 285 ASN A CG  1 
ATOM   2030 O  OD1 . ASN A 1 280 ? -7.544  2.195   26.334  1.00 23.01 ? 285 ASN A OD1 1 
ATOM   2031 N  ND2 . ASN A 1 280 ? -7.164  1.189   24.327  1.00 19.60 ? 285 ASN A ND2 1 
ATOM   2032 N  N   . THR A 1 281 ? -4.725  6.397   25.044  1.00 19.96 ? 286 THR A N   1 
ATOM   2033 C  CA  . THR A 1 281 ? -3.541  7.286   25.013  1.00 20.04 ? 286 THR A CA  1 
ATOM   2034 C  C   . THR A 1 281 ? -3.237  7.952   26.365  1.00 20.44 ? 286 THR A C   1 
ATOM   2035 O  O   . THR A 1 281 ? -2.086  8.310   26.631  1.00 20.15 ? 286 THR A O   1 
ATOM   2036 C  CB  . THR A 1 281 ? -3.651  8.431   23.957  1.00 20.10 ? 286 THR A CB  1 
ATOM   2037 O  OG1 . THR A 1 281 ? -4.700  9.347   24.340  1.00 18.47 ? 286 THR A OG1 1 
ATOM   2038 C  CG2 . THR A 1 281 ? -3.906  7.898   22.560  1.00 20.24 ? 286 THR A CG2 1 
ATOM   2039 N  N   . GLY A 1 282 ? -4.265  8.090   27.195  1.00 19.72 ? 287 GLY A N   1 
ATOM   2040 C  CA  . GLY A 1 282 ? -4.235  8.889   28.417  1.00 20.64 ? 287 GLY A CA  1 
ATOM   2041 C  C   . GLY A 1 282 ? -4.031  10.368  28.142  1.00 20.43 ? 287 GLY A C   1 
ATOM   2042 O  O   . GLY A 1 282 ? -3.683  11.129  29.050  1.00 20.59 ? 287 GLY A O   1 
ATOM   2043 N  N   . LEU A 1 283 ? -4.201  10.786  26.891  1.00 19.44 ? 288 LEU A N   1 
ATOM   2044 C  CA  . LEU A 1 283 ? -3.850  12.154  26.521  1.00 18.96 ? 288 LEU A CA  1 
ATOM   2045 C  C   . LEU A 1 283 ? -5.060  13.056  26.228  1.00 18.85 ? 288 LEU A C   1 
ATOM   2046 O  O   . LEU A 1 283 ? -4.885  14.247  25.942  1.00 19.22 ? 288 LEU A O   1 
ATOM   2047 C  CB  . LEU A 1 283 ? -2.843  12.191  25.362  1.00 19.45 ? 288 LEU A CB  1 
ATOM   2048 C  CG  . LEU A 1 283 ? -1.402  11.720  25.658  1.00 17.98 ? 288 LEU A CG  1 
ATOM   2049 C  CD1 . LEU A 1 283 ? -0.684  11.504  24.373  1.00 18.61 ? 288 LEU A CD1 1 
ATOM   2050 C  CD2 . LEU A 1 283 ? -0.693  12.753  26.547  1.00 20.76 ? 288 LEU A CD2 1 
ATOM   2051 N  N   . LEU A 1 284 ? -6.275  12.502  26.290  1.00 16.96 ? 289 LEU A N   1 
ATOM   2052 C  CA  . LEU A 1 284 ? -7.442  13.316  25.948  1.00 17.22 ? 289 LEU A CA  1 
ATOM   2053 C  C   . LEU A 1 284 ? -7.595  14.523  26.881  1.00 16.48 ? 289 LEU A C   1 
ATOM   2054 O  O   . LEU A 1 284 ? -7.698  14.353  28.086  1.00 17.80 ? 289 LEU A O   1 
ATOM   2055 C  CB  . LEU A 1 284 ? -8.710  12.478  25.995  1.00 16.52 ? 289 LEU A CB  1 
ATOM   2056 C  CG  . LEU A 1 284 ? -9.941  13.300  25.609  1.00 18.24 ? 289 LEU A CG  1 
ATOM   2057 C  CD1 . LEU A 1 284 ? -9.862  13.781  24.144  1.00 18.41 ? 289 LEU A CD1 1 
ATOM   2058 C  CD2 . LEU A 1 284 ? -11.142 12.448  25.843  1.00 17.42 ? 289 LEU A CD2 1 
ATOM   2059 N  N   . SER A 1 285 ? -7.659  15.720  26.314  1.00 15.99 ? 290 SER A N   1 
ATOM   2060 C  CA  . SER A 1 285 ? -7.649  16.958  27.091  1.00 16.47 ? 290 SER A CA  1 
ATOM   2061 C  C   . SER A 1 285 ? -8.930  17.804  26.897  1.00 16.25 ? 290 SER A C   1 
ATOM   2062 O  O   . SER A 1 285 ? -9.333  18.503  27.820  1.00 16.98 ? 290 SER A O   1 
ATOM   2063 C  CB  . SER A 1 285 ? -6.339  17.721  26.793  1.00 16.72 ? 290 SER A CB  1 
ATOM   2064 O  OG  . SER A 1 285 ? -6.248  18.926  27.520  1.00 20.63 ? 290 SER A OG  1 
ATOM   2065 N  N   . ALA A 1 286 ? -9.577  17.709  25.728  1.00 15.62 ? 291 ALA A N   1 
ATOM   2066 C  CA  . ALA A 1 286 ? -10.914 18.265  25.493  1.00 15.05 ? 291 ALA A CA  1 
ATOM   2067 C  C   . ALA A 1 286 ? -11.601 17.495  24.392  1.00 15.14 ? 291 ALA A C   1 
ATOM   2068 O  O   . ALA A 1 286 ? -10.941 16.934  23.506  1.00 15.92 ? 291 ALA A O   1 
ATOM   2069 C  CB  . ALA A 1 286 ? -10.858 19.780  25.131  1.00 16.08 ? 291 ALA A CB  1 
ATOM   2070 N  N   . LEU A 1 287 ? -12.937 17.462  24.432  1.00 14.14 ? 292 LEU A N   1 
ATOM   2071 C  CA  . LEU A 1 287 ? -13.715 16.685  23.481  1.00 14.07 ? 292 LEU A CA  1 
ATOM   2072 C  C   . LEU A 1 287 ? -14.944 17.536  23.194  1.00 14.54 ? 292 LEU A C   1 
ATOM   2073 O  O   . LEU A 1 287 ? -15.526 18.091  24.137  1.00 13.07 ? 292 LEU A O   1 
ATOM   2074 C  CB  . LEU A 1 287 ? -14.152 15.353  24.126  1.00 14.89 ? 292 LEU A CB  1 
ATOM   2075 C  CG  . LEU A 1 287 ? -15.009 14.350  23.364  1.00 17.07 ? 292 LEU A CG  1 
ATOM   2076 C  CD1 . LEU A 1 287 ? -14.840 12.994  23.989  1.00 19.27 ? 292 LEU A CD1 1 
ATOM   2077 C  CD2 . LEU A 1 287 ? -16.528 14.766  23.394  1.00 20.54 ? 292 LEU A CD2 1 
ATOM   2078 N  N   . ASP A 1 288 ? -15.270 17.694  21.908  1.00 14.23 ? 293 ASP A N   1 
ATOM   2079 C  CA  . ASP A 1 288 ? -16.549 18.296  21.484  1.00 16.03 ? 293 ASP A CA  1 
ATOM   2080 C  C   . ASP A 1 288 ? -17.428 17.169  20.994  1.00 15.49 ? 293 ASP A C   1 
ATOM   2081 O  O   . ASP A 1 288 ? -16.951 16.249  20.312  1.00 15.40 ? 293 ASP A O   1 
ATOM   2082 C  CB  . ASP A 1 288 ? -16.362 19.274  20.285  1.00 15.65 ? 293 ASP A CB  1 
ATOM   2083 C  CG  . ASP A 1 288 ? -15.233 20.206  20.475  1.00 17.55 ? 293 ASP A CG  1 
ATOM   2084 O  OD1 . ASP A 1 288 ? -15.094 20.764  21.584  1.00 16.27 ? 293 ASP A OD1 1 
ATOM   2085 O  OD2 . ASP A 1 288 ? -14.463 20.377  19.509  1.00 17.44 ? 293 ASP A OD2 1 
ATOM   2086 N  N   . LEU A 1 289 ? -18.714 17.220  21.316  1.00 15.80 ? 294 LEU A N   1 
ATOM   2087 C  CA  . LEU A 1 289 ? -19.672 16.281  20.768  1.00 15.75 ? 294 LEU A CA  1 
ATOM   2088 C  C   . LEU A 1 289 ? -20.810 17.128  20.173  1.00 16.51 ? 294 LEU A C   1 
ATOM   2089 O  O   . LEU A 1 289 ? -21.645 17.646  20.911  1.00 16.72 ? 294 LEU A O   1 
ATOM   2090 C  CB  . LEU A 1 289 ? -20.204 15.297  21.823  1.00 15.54 ? 294 LEU A CB  1 
ATOM   2091 C  CG  . LEU A 1 289 ? -20.870 13.997  21.315  1.00 16.35 ? 294 LEU A CG  1 
ATOM   2092 C  CD1 . LEU A 1 289 ? -22.110 14.261  20.402  1.00 16.27 ? 294 LEU A CD1 1 
ATOM   2093 C  CD2 . LEU A 1 289 ? -19.891 13.043  20.611  1.00 15.84 ? 294 LEU A CD2 1 
ATOM   2094 N  N   . VAL A 1 290 ? -20.780 17.282  18.851  1.00 15.28 ? 295 VAL A N   1 
ATOM   2095 C  CA  . VAL A 1 290 ? -21.570 18.287  18.138  1.00 15.91 ? 295 VAL A CA  1 
ATOM   2096 C  C   . VAL A 1 290 ? -22.595 17.691  17.168  1.00 15.68 ? 295 VAL A C   1 
ATOM   2097 O  O   . VAL A 1 290 ? -22.546 16.507  16.820  1.00 14.25 ? 295 VAL A O   1 
ATOM   2098 C  CB  . VAL A 1 290 ? -20.674 19.343  17.401  1.00 15.10 ? 295 VAL A CB  1 
ATOM   2099 C  CG1 . VAL A 1 290 ? -19.713 20.023  18.365  1.00 17.38 ? 295 VAL A CG1 1 
ATOM   2100 C  CG2 . VAL A 1 290 ? -19.885 18.718  16.225  1.00 16.19 ? 295 VAL A CG2 1 
ATOM   2101 N  N   . GLU A 1 291 ? -23.548 18.543  16.784  1.00 15.99 ? 296 GLU A N   1 
ATOM   2102 C  CA  . GLU A 1 291 ? -24.511 18.333  15.682  1.00 16.95 ? 296 GLU A CA  1 
ATOM   2103 C  C   . GLU A 1 291 ? -25.669 17.393  15.971  1.00 17.41 ? 296 GLU A C   1 
ATOM   2104 O  O   . GLU A 1 291 ? -26.387 16.998  15.068  1.00 17.08 ? 296 GLU A O   1 
ATOM   2105 C  CB  . GLU A 1 291 ? -23.824 18.019  14.324  1.00 16.95 ? 296 GLU A CB  1 
ATOM   2106 C  CG  . GLU A 1 291 ? -22.871 19.153  13.844  1.00 16.19 ? 296 GLU A CG  1 
ATOM   2107 C  CD  . GLU A 1 291 ? -23.559 20.401  13.268  1.00 19.09 ? 296 GLU A CD  1 
ATOM   2108 O  OE1 . GLU A 1 291 ? -24.796 20.429  13.147  1.00 19.57 ? 296 GLU A OE1 1 
ATOM   2109 O  OE2 . GLU A 1 291 ? -22.835 21.343  12.885  1.00 17.74 ? 296 GLU A OE2 1 
ATOM   2110 N  N   . VAL A 1 292 ? -25.836 17.010  17.230  1.00 17.89 ? 297 VAL A N   1 
ATOM   2111 C  CA  . VAL A 1 292 ? -27.034 16.286  17.619  1.00 18.60 ? 297 VAL A CA  1 
ATOM   2112 C  C   . VAL A 1 292 ? -28.212 17.288  17.568  1.00 20.10 ? 297 VAL A C   1 
ATOM   2113 O  O   . VAL A 1 292 ? -28.191 18.337  18.239  1.00 19.58 ? 297 VAL A O   1 
ATOM   2114 C  CB  . VAL A 1 292 ? -26.931 15.643  19.014  1.00 19.48 ? 297 VAL A CB  1 
ATOM   2115 C  CG1 . VAL A 1 292 ? -28.328 15.088  19.449  1.00 18.65 ? 297 VAL A CG1 1 
ATOM   2116 C  CG2 . VAL A 1 292 ? -25.828 14.535  19.062  1.00 16.89 ? 297 VAL A CG2 1 
ATOM   2117 N  N   . ASN A 1 293 ? -29.194 16.964  16.731  1.00 20.54 ? 298 ASN A N   1 
ATOM   2118 C  CA  . ASN A 1 293 ? -30.402 17.810  16.551  1.00 22.23 ? 298 ASN A CA  1 
ATOM   2119 C  C   . ASN A 1 293 ? -31.609 16.912  16.719  1.00 22.62 ? 298 ASN A C   1 
ATOM   2120 O  O   . ASN A 1 293 ? -32.034 16.305  15.753  1.00 22.82 ? 298 ASN A O   1 
ATOM   2121 C  CB  . ASN A 1 293 ? -30.426 18.469  15.164  1.00 21.46 ? 298 ASN A CB  1 
ATOM   2122 C  CG  . ASN A 1 293 ? -31.602 19.436  14.986  1.00 22.48 ? 298 ASN A CG  1 
ATOM   2123 O  OD1 . ASN A 1 293 ? -32.578 19.377  15.728  1.00 22.37 ? 298 ASN A OD1 1 
ATOM   2124 N  ND2 . ASN A 1 293 ? -31.486 20.343  14.025  1.00 22.25 ? 298 ASN A ND2 1 
ATOM   2125 N  N   . PRO A 1 294 ? -32.167 16.820  17.950  1.00 23.61 ? 299 PRO A N   1 
ATOM   2126 C  CA  . PRO A 1 294 ? -33.260 15.869  18.173  1.00 24.55 ? 299 PRO A CA  1 
ATOM   2127 C  C   . PRO A 1 294 ? -34.487 16.173  17.329  1.00 25.92 ? 299 PRO A C   1 
ATOM   2128 O  O   . PRO A 1 294 ? -35.260 15.266  17.040  1.00 26.26 ? 299 PRO A O   1 
ATOM   2129 C  CB  . PRO A 1 294 ? -33.592 16.021  19.663  1.00 24.35 ? 299 PRO A CB  1 
ATOM   2130 C  CG  . PRO A 1 294 ? -32.981 17.255  20.090  1.00 25.07 ? 299 PRO A CG  1 
ATOM   2131 C  CD  . PRO A 1 294 ? -31.860 17.600  19.155  1.00 23.80 ? 299 PRO A CD  1 
ATOM   2132 N  N   . GLN A 1 295 ? -34.640 17.422  16.909  1.00 27.55 ? 300 GLN A N   1 
ATOM   2133 C  CA  . GLN A 1 295 ? -35.817 17.812  16.121  1.00 29.61 ? 300 GLN A CA  1 
ATOM   2134 C  C   . GLN A 1 295 ? -35.842 17.185  14.709  1.00 29.62 ? 300 GLN A C   1 
ATOM   2135 O  O   . GLN A 1 295 ? -36.908 17.112  14.086  1.00 29.18 ? 300 GLN A O   1 
ATOM   2136 C  CB  . GLN A 1 295 ? -35.918 19.337  16.028  1.00 30.12 ? 300 GLN A CB  1 
ATOM   2137 C  CG  . GLN A 1 295 ? -36.375 20.030  17.311  1.00 35.07 ? 300 GLN A CG  1 
ATOM   2138 C  CD  . GLN A 1 295 ? -36.624 21.518  17.104  1.00 39.28 ? 300 GLN A CD  1 
ATOM   2139 O  OE1 . GLN A 1 295 ? -37.171 21.929  16.082  1.00 42.78 ? 300 GLN A OE1 1 
ATOM   2140 N  NE2 . GLN A 1 295 ? -36.225 22.328  18.070  1.00 40.97 ? 300 GLN A NE2 1 
ATOM   2141 N  N   . LEU A 1 296 ? -34.682 16.727  14.222  1.00 29.13 ? 301 LEU A N   1 
ATOM   2142 C  CA  . LEU A 1 296 ? -34.576 16.179  12.880  1.00 28.82 ? 301 LEU A CA  1 
ATOM   2143 C  C   . LEU A 1 296 ? -34.790 14.692  12.862  1.00 29.14 ? 301 LEU A C   1 
ATOM   2144 O  O   . LEU A 1 296 ? -34.774 14.078  11.793  1.00 29.58 ? 301 LEU A O   1 
ATOM   2145 C  CB  . LEU A 1 296 ? -33.242 16.560  12.203  1.00 28.74 ? 301 LEU A CB  1 
ATOM   2146 C  CG  . LEU A 1 296 ? -33.037 18.064  12.033  1.00 28.73 ? 301 LEU A CG  1 
ATOM   2147 C  CD1 . LEU A 1 296 ? -31.731 18.365  11.324  1.00 28.37 ? 301 LEU A CD1 1 
ATOM   2148 C  CD2 . LEU A 1 296 ? -34.217 18.742  11.291  1.00 30.41 ? 301 LEU A CD2 1 
ATOM   2149 N  N   . ALA A 1 297 ? -35.010 14.107  14.037  1.00 28.72 ? 302 ALA A N   1 
ATOM   2150 C  CA  . ALA A 1 297 ? -35.433 12.723  14.115  1.00 29.69 ? 302 ALA A CA  1 
ATOM   2151 C  C   . ALA A 1 297 ? -36.865 12.662  13.587  1.00 30.29 ? 302 ALA A C   1 
ATOM   2152 O  O   . ALA A 1 297 ? -37.576 13.669  13.625  1.00 30.08 ? 302 ALA A O   1 
ATOM   2153 C  CB  . ALA A 1 297 ? -35.383 12.231  15.541  1.00 29.34 ? 302 ALA A CB  1 
ATOM   2154 N  N   . THR A 1 298 ? -37.260 11.494  13.086  1.00 31.23 ? 303 THR A N   1 
ATOM   2155 C  CA  . THR A 1 298 ? -38.641 11.261  12.659  1.00 32.06 ? 303 THR A CA  1 
ATOM   2156 C  C   . THR A 1 298 ? -39.423 10.569  13.777  1.00 32.47 ? 303 THR A C   1 
ATOM   2157 O  O   . THR A 1 298 ? -40.652 10.484  13.711  1.00 32.98 ? 303 THR A O   1 
ATOM   2158 C  CB  . THR A 1 298 ? -38.723 10.426  11.355  1.00 31.84 ? 303 THR A CB  1 
ATOM   2159 O  OG1 . THR A 1 298 ? -38.194 9.122   11.590  1.00 31.55 ? 303 THR A OG1 1 
ATOM   2160 C  CG2 . THR A 1 298 ? -37.951 11.094  10.198  1.00 33.30 ? 303 THR A CG2 1 
ATOM   2161 N  N   . SER A 1 299 ? -38.707 10.085  14.801  1.00 32.39 ? 304 SER A N   1 
ATOM   2162 C  CA  . SER A 1 299 ? -39.298 9.386   15.950  1.00 32.66 ? 304 SER A CA  1 
ATOM   2163 C  C   . SER A 1 299 ? -38.465 9.582   17.226  1.00 32.90 ? 304 SER A C   1 
ATOM   2164 O  O   . SER A 1 299 ? -37.248 9.840   17.159  1.00 32.77 ? 304 SER A O   1 
ATOM   2165 C  CB  . SER A 1 299 ? -39.466 7.882   15.665  1.00 32.94 ? 304 SER A CB  1 
ATOM   2166 O  OG  . SER A 1 299 ? -38.241 7.157   15.837  1.00 33.86 ? 304 SER A OG  1 
ATOM   2167 N  N   . GLU A 1 300 ? -39.106 9.423   18.381  1.00 32.77 ? 305 GLU A N   1 
ATOM   2168 C  CA  . GLU A 1 300 ? -38.399 9.453   19.653  1.00 33.16 ? 305 GLU A CA  1 
ATOM   2169 C  C   . GLU A 1 300 ? -37.253 8.445   19.736  1.00 33.11 ? 305 GLU A C   1 
ATOM   2170 O  O   . GLU A 1 300 ? -36.194 8.766   20.301  1.00 32.14 ? 305 GLU A O   1 
ATOM   2171 C  CB  . GLU A 1 300 ? -39.331 9.259   20.827  1.00 34.01 ? 305 GLU A CB  1 
ATOM   2172 C  CG  . GLU A 1 300 ? -38.666 9.484   22.186  1.00 35.98 ? 305 GLU A CG  1 
ATOM   2173 C  CD  . GLU A 1 300 ? -39.605 9.184   23.338  1.00 39.02 ? 305 GLU A CD  1 
ATOM   2174 O  OE1 . GLU A 1 300 ? -40.838 9.218   23.127  1.00 42.39 ? 305 GLU A OE1 1 
ATOM   2175 O  OE2 . GLU A 1 300 ? -39.111 8.918   24.453  1.00 41.20 ? 305 GLU A OE2 1 
ATOM   2176 N  N   . GLU A 1 301 ? -37.446 7.246   19.186  1.00 32.59 ? 306 GLU A N   1 
ATOM   2177 C  CA  . GLU A 1 301 ? -36.357 6.273   19.190  1.00 33.12 ? 306 GLU A CA  1 
ATOM   2178 C  C   . GLU A 1 301 ? -35.148 6.704   18.310  1.00 31.98 ? 306 GLU A C   1 
ATOM   2179 O  O   . GLU A 1 301 ? -34.006 6.426   18.670  1.00 31.87 ? 306 GLU A O   1 
ATOM   2180 C  CB  . GLU A 1 301 ? -36.854 4.857   18.868  1.00 33.57 ? 306 GLU A CB  1 
ATOM   2181 C  CG  . GLU A 1 301 ? -36.636 4.396   17.446  1.00 38.64 ? 306 GLU A CG  1 
ATOM   2182 C  CD  . GLU A 1 301 ? -36.743 2.875   17.296  1.00 43.57 ? 306 GLU A CD  1 
ATOM   2183 O  OE1 . GLU A 1 301 ? -37.285 2.208   18.208  1.00 45.26 ? 306 GLU A OE1 1 
ATOM   2184 O  OE2 . GLU A 1 301 ? -36.289 2.355   16.251  1.00 47.23 ? 306 GLU A OE2 1 
ATOM   2185 N  N   . GLU A 1 302 ? -35.405 7.379   17.186  1.00 29.96 ? 307 GLU A N   1 
ATOM   2186 C  CA  . GLU A 1 302 ? -34.343 7.965   16.368  1.00 28.70 ? 307 GLU A CA  1 
ATOM   2187 C  C   . GLU A 1 302 ? -33.584 9.055   17.123  1.00 28.16 ? 307 GLU A C   1 
ATOM   2188 O  O   . GLU A 1 302 ? -32.338 9.105   17.060  1.00 27.31 ? 307 GLU A O   1 
ATOM   2189 C  CB  . GLU A 1 302 ? -34.877 8.533   15.063  1.00 28.28 ? 307 GLU A CB  1 
ATOM   2190 C  CG  . GLU A 1 302 ? -35.155 7.488   13.976  1.00 29.50 ? 307 GLU A CG  1 
ATOM   2191 C  CD  . GLU A 1 302 ? -35.207 8.098   12.573  1.00 30.61 ? 307 GLU A CD  1 
ATOM   2192 O  OE1 . GLU A 1 302 ? -35.285 9.338   12.434  1.00 27.46 ? 307 GLU A OE1 1 
ATOM   2193 O  OE2 . GLU A 1 302 ? -35.151 7.328   11.596  1.00 34.47 ? 307 GLU A OE2 1 
ATOM   2194 N  N   . ALA A 1 303 ? -34.329 9.919   17.822  1.00 26.54 ? 308 ALA A N   1 
ATOM   2195 C  CA  . ALA A 1 303 ? -33.740 10.967  18.665  1.00 26.55 ? 308 ALA A CA  1 
ATOM   2196 C  C   . ALA A 1 303 ? -32.959 10.392  19.844  1.00 26.05 ? 308 ALA A C   1 
ATOM   2197 O  O   . ALA A 1 303 ? -31.828 10.816  20.112  1.00 24.98 ? 308 ALA A O   1 
ATOM   2198 C  CB  . ALA A 1 303 ? -34.820 11.987  19.168  1.00 25.98 ? 308 ALA A CB  1 
ATOM   2199 N  N   . LYS A 1 304 ? -33.555 9.433   20.550  1.00 26.05 ? 309 LYS A N   1 
ATOM   2200 C  CA  . LYS A 1 304 ? -32.883 8.867   21.715  1.00 26.73 ? 309 LYS A CA  1 
ATOM   2201 C  C   . LYS A 1 304 ? -31.670 8.026   21.320  1.00 26.51 ? 309 LYS A C   1 
ATOM   2202 O  O   . LYS A 1 304 ? -30.664 8.017   22.046  1.00 25.94 ? 309 LYS A O   1 
ATOM   2203 C  CB  . LYS A 1 304 ? -33.851 8.068   22.602  1.00 27.59 ? 309 LYS A CB  1 
ATOM   2204 C  CG  . LYS A 1 304 ? -34.784 8.979   23.422  1.00 30.60 ? 309 LYS A CG  1 
ATOM   2205 C  CD  . LYS A 1 304 ? -35.717 8.171   24.311  1.00 35.85 ? 309 LYS A CD  1 
ATOM   2206 C  CE  . LYS A 1 304 ? -36.091 8.955   25.567  1.00 39.84 ? 309 LYS A CE  1 
ATOM   2207 N  NZ  . LYS A 1 304 ? -36.892 8.113   26.517  1.00 41.11 ? 309 LYS A NZ  1 
ATOM   2208 N  N   . THR A 1 305 ? -31.748 7.341   20.177  1.00 25.95 ? 310 THR A N   1 
ATOM   2209 C  CA  . THR A 1 305 ? -30.626 6.493   19.739  1.00 26.14 ? 310 THR A CA  1 
ATOM   2210 C  C   . THR A 1 305 ? -29.435 7.406   19.453  1.00 23.81 ? 310 THR A C   1 
ATOM   2211 O  O   . THR A 1 305 ? -28.311 7.131   19.872  1.00 24.51 ? 310 THR A O   1 
ATOM   2212 C  CB  . THR A 1 305 ? -30.988 5.617   18.530  1.00 25.53 ? 310 THR A CB  1 
ATOM   2213 O  OG1 . THR A 1 305 ? -32.060 4.750   18.910  1.00 31.36 ? 310 THR A OG1 1 
ATOM   2214 C  CG2 . THR A 1 305 ? -29.819 4.709   18.128  1.00 28.10 ? 310 THR A CG2 1 
ATOM   2215 N  N   . THR A 1 306 ? -29.706 8.526   18.794  1.00 22.07 ? 311 THR A N   1 
ATOM   2216 C  CA  . THR A 1 306 ? -28.664 9.497   18.491  1.00 20.58 ? 311 THR A CA  1 
ATOM   2217 C  C   . THR A 1 306 ? -28.047 10.084  19.757  1.00 19.96 ? 311 THR A C   1 
ATOM   2218 O  O   . THR A 1 306 ? -26.813 10.131  19.899  1.00 19.70 ? 311 THR A O   1 
ATOM   2219 C  CB  . THR A 1 306 ? -29.209 10.643  17.607  1.00 20.21 ? 311 THR A CB  1 
ATOM   2220 O  OG1 . THR A 1 306 ? -29.811 10.074  16.436  1.00 17.26 ? 311 THR A OG1 1 
ATOM   2221 C  CG2 . THR A 1 306 ? -28.082 11.607  17.227  1.00 17.74 ? 311 THR A CG2 1 
ATOM   2222 N  N   . ALA A 1 307 ? -28.895 10.525  20.687  1.00 19.32 ? 312 ALA A N   1 
ATOM   2223 C  CA  . ALA A 1 307 ? -28.395 10.953  22.003  1.00 19.22 ? 312 ALA A CA  1 
ATOM   2224 C  C   . ALA A 1 307 ? -27.667 9.853   22.781  1.00 18.25 ? 312 ALA A C   1 
ATOM   2225 O  O   . ALA A 1 307 ? -26.628 10.115  23.408  1.00 18.75 ? 312 ALA A O   1 
ATOM   2226 C  CB  . ALA A 1 307 ? -29.527 11.572  22.864  1.00 20.12 ? 312 ALA A CB  1 
ATOM   2227 N  N   . ASN A 1 308 ? -28.151 8.626   22.725  1.00 18.21 ? 313 ASN A N   1 
ATOM   2228 C  CA  . ASN A 1 308 ? -27.498 7.521   23.475  1.00 18.89 ? 313 ASN A CA  1 
ATOM   2229 C  C   . ASN A 1 308 ? -26.095 7.247   22.888  1.00 18.21 ? 313 ASN A C   1 
ATOM   2230 O  O   . ASN A 1 308 ? -25.137 6.894   23.600  1.00 18.18 ? 313 ASN A O   1 
ATOM   2231 C  CB  . ASN A 1 308 ? -28.331 6.244   23.400  1.00 19.37 ? 313 ASN A CB  1 
ATOM   2232 C  CG  . ASN A 1 308 ? -29.613 6.300   24.265  1.00 21.11 ? 313 ASN A CG  1 
ATOM   2233 O  OD1 . ASN A 1 308 ? -29.740 7.129   25.158  1.00 21.59 ? 313 ASN A OD1 1 
ATOM   2234 N  ND2 . ASN A 1 308 ? -30.549 5.403   23.979  1.00 21.23 ? 313 ASN A ND2 1 
ATOM   2235 N  N   . LEU A 1 309 ? -26.002 7.424   21.576  1.00 17.97 ? 314 LEU A N   1 
ATOM   2236 C  CA  . LEU A 1 309 ? -24.779 7.131   20.849  1.00 17.10 ? 314 LEU A CA  1 
ATOM   2237 C  C   . LEU A 1 309 ? -23.775 8.214   21.227  1.00 16.07 ? 314 LEU A C   1 
ATOM   2238 O  O   . LEU A 1 309 ? -22.608 7.921   21.496  1.00 16.43 ? 314 LEU A O   1 
ATOM   2239 C  CB  . LEU A 1 309 ? -25.060 7.166   19.341  1.00 17.22 ? 314 LEU A CB  1 
ATOM   2240 C  CG  . LEU A 1 309 ? -23.877 7.067   18.392  1.00 16.84 ? 314 LEU A CG  1 
ATOM   2241 C  CD1 . LEU A 1 309 ? -23.121 5.760   18.742  1.00 17.64 ? 314 LEU A CD1 1 
ATOM   2242 C  CD2 . LEU A 1 309 ? -24.384 7.001   16.948  1.00 18.58 ? 314 LEU A CD2 1 
ATOM   2243 N  N   . ALA A 1 310 ? -24.264 9.453   21.301  1.00 15.50 ? 315 ALA A N   1 
ATOM   2244 C  CA  . ALA A 1 310 ? -23.471 10.593  21.784  1.00 15.71 ? 315 ALA A CA  1 
ATOM   2245 C  C   . ALA A 1 310 ? -22.901 10.303  23.184  1.00 15.83 ? 315 ALA A C   1 
ATOM   2246 O  O   . ALA A 1 310 ? -21.703 10.522  23.454  1.00 15.31 ? 315 ALA A O   1 
ATOM   2247 C  CB  . ALA A 1 310 ? -24.302 11.870  21.783  1.00 15.78 ? 315 ALA A CB  1 
ATOM   2248 N  N   . VAL A 1 311 ? -23.745 9.785   24.073  1.00 15.16 ? 316 VAL A N   1 
ATOM   2249 C  CA  . VAL A 1 311 ? -23.263 9.414   25.405  1.00 15.11 ? 316 VAL A CA  1 
ATOM   2250 C  C   . VAL A 1 311 ? -22.210 8.278   25.324  1.00 14.49 ? 316 VAL A C   1 
ATOM   2251 O  O   . VAL A 1 311 ? -21.193 8.341   26.026  1.00 15.68 ? 316 VAL A O   1 
ATOM   2252 C  CB  . VAL A 1 311 ? -24.437 9.095   26.384  1.00 15.73 ? 316 VAL A CB  1 
ATOM   2253 C  CG1 . VAL A 1 311 ? -23.906 8.526   27.701  1.00 15.48 ? 316 VAL A CG1 1 
ATOM   2254 C  CG2 . VAL A 1 311 ? -25.236 10.371  26.640  1.00 14.99 ? 316 VAL A CG2 1 
ATOM   2255 N  N   . ASP A 1 312 ? -22.426 7.286   24.447  1.00 14.47 ? 317 ASP A N   1 
ATOM   2256 C  CA  . ASP A 1 312 ? -21.486 6.161   24.323  1.00 15.34 ? 317 ASP A CA  1 
ATOM   2257 C  C   . ASP A 1 312 ? -20.121 6.664   23.857  1.00 14.75 ? 317 ASP A C   1 
ATOM   2258 O  O   . ASP A 1 312 ? -19.068 6.181   24.334  1.00 15.34 ? 317 ASP A O   1 
ATOM   2259 C  CB  . ASP A 1 312 ? -22.005 5.087   23.350  1.00 14.99 ? 317 ASP A CB  1 
ATOM   2260 C  CG  . ASP A 1 312 ? -23.021 4.127   23.978  1.00 17.18 ? 317 ASP A CG  1 
ATOM   2261 O  OD1 . ASP A 1 312 ? -23.224 4.164   25.194  1.00 18.80 ? 317 ASP A OD1 1 
ATOM   2262 O  OD2 . ASP A 1 312 ? -23.609 3.314   23.238  1.00 17.27 ? 317 ASP A OD2 1 
ATOM   2263 N  N   . VAL A 1 313 ? -20.120 7.621   22.919  1.00 14.12 ? 318 VAL A N   1 
ATOM   2264 C  CA  . VAL A 1 313 ? -18.860 8.196   22.453  1.00 13.46 ? 318 VAL A CA  1 
ATOM   2265 C  C   . VAL A 1 313 ? -18.096 8.837   23.628  1.00 13.88 ? 318 VAL A C   1 
ATOM   2266 O  O   . VAL A 1 313 ? -16.871 8.602   23.814  1.00 14.30 ? 318 VAL A O   1 
ATOM   2267 C  CB  . VAL A 1 313 ? -19.058 9.224   21.293  1.00 13.07 ? 318 VAL A CB  1 
ATOM   2268 C  CG1 . VAL A 1 313 ? -17.739 9.940   20.966  1.00 15.51 ? 318 VAL A CG1 1 
ATOM   2269 C  CG2 . VAL A 1 313 ? -19.587 8.487   20.025  1.00 15.60 ? 318 VAL A CG2 1 
ATOM   2270 N  N   . ILE A 1 314 ? -18.811 9.669   24.396  1.00 13.80 ? 319 ILE A N   1 
ATOM   2271 C  CA  . ILE A 1 314 ? -18.180 10.438  25.469  1.00 14.25 ? 319 ILE A CA  1 
ATOM   2272 C  C   . ILE A 1 314 ? -17.710 9.494   26.560  1.00 14.12 ? 319 ILE A C   1 
ATOM   2273 O  O   . ILE A 1 314 ? -16.549 9.556   26.988  1.00 12.83 ? 319 ILE A O   1 
ATOM   2274 C  CB  . ILE A 1 314 ? -19.096 11.538  26.027  1.00 14.78 ? 319 ILE A CB  1 
ATOM   2275 C  CG1 . ILE A 1 314 ? -19.409 12.562  24.929  1.00 15.34 ? 319 ILE A CG1 1 
ATOM   2276 C  CG2 . ILE A 1 314 ? -18.389 12.236  27.230  1.00 15.15 ? 319 ILE A CG2 1 
ATOM   2277 C  CD1 . ILE A 1 314 ? -20.595 13.449  25.223  1.00 15.29 ? 319 ILE A CD1 1 
ATOM   2278 N  N   . ALA A 1 315 ? -18.585 8.581   26.954  1.00 14.47 ? 320 ALA A N   1 
ATOM   2279 C  CA  . ALA A 1 315 ? -18.244 7.526   27.918  1.00 15.21 ? 320 ALA A CA  1 
ATOM   2280 C  C   . ALA A 1 315 ? -17.008 6.737   27.508  1.00 15.70 ? 320 ALA A C   1 
ATOM   2281 O  O   . ALA A 1 315 ? -16.138 6.511   28.332  1.00 15.78 ? 320 ALA A O   1 
ATOM   2282 C  CB  . ALA A 1 315 ? -19.423 6.575   28.129  1.00 14.97 ? 320 ALA A CB  1 
ATOM   2283 N  N   . SER A 1 316 ? -16.951 6.317   26.235  1.00 15.98 ? 321 SER A N   1 
ATOM   2284 C  CA  . SER A 1 316 ? -15.864 5.496   25.739  1.00 16.48 ? 321 SER A CA  1 
ATOM   2285 C  C   . SER A 1 316 ? -14.553 6.277   25.687  1.00 15.95 ? 321 SER A C   1 
ATOM   2286 O  O   . SER A 1 316 ? -13.474 5.706   25.827  1.00 16.59 ? 321 SER A O   1 
ATOM   2287 C  CB  . SER A 1 316 ? -16.223 4.891   24.363  1.00 16.23 ? 321 SER A CB  1 
ATOM   2288 O  OG  . SER A 1 316 ? -17.245 3.922   24.573  1.00 19.56 ? 321 SER A OG  1 
ATOM   2289 N  N   . SER A 1 317 ? -14.663 7.592   25.547  1.00 16.04 ? 322 SER A N   1 
ATOM   2290 C  CA  . SER A 1 317 ? -13.498 8.451   25.587  1.00 16.41 ? 322 SER A CA  1 
ATOM   2291 C  C   . SER A 1 317 ? -12.905 8.538   27.003  1.00 16.32 ? 322 SER A C   1 
ATOM   2292 O  O   . SER A 1 317 ? -11.777 8.994   27.161  1.00 16.57 ? 322 SER A O   1 
ATOM   2293 C  CB  . SER A 1 317 ? -13.843 9.859   25.054  1.00 16.98 ? 322 SER A CB  1 
ATOM   2294 O  OG  . SER A 1 317 ? -14.214 9.794   23.682  1.00 18.87 ? 322 SER A OG  1 
ATOM   2295 N  N   . PHE A 1 318 ? -13.680 8.124   28.012  1.00 15.77 ? 323 PHE A N   1 
ATOM   2296 C  CA  . PHE A 1 318 ? -13.255 8.183   29.424  1.00 16.44 ? 323 PHE A CA  1 
ATOM   2297 C  C   . PHE A 1 318 ? -13.263 6.845   30.146  1.00 16.96 ? 323 PHE A C   1 
ATOM   2298 O  O   . PHE A 1 318 ? -13.401 6.782   31.380  1.00 16.20 ? 323 PHE A O   1 
ATOM   2299 C  CB  . PHE A 1 318 ? -14.059 9.253   30.180  1.00 16.84 ? 323 PHE A CB  1 
ATOM   2300 C  CG  . PHE A 1 318 ? -13.748 10.638  29.702  1.00 17.01 ? 323 PHE A CG  1 
ATOM   2301 C  CD1 . PHE A 1 318 ? -12.500 11.198  29.974  1.00 16.46 ? 323 PHE A CD1 1 
ATOM   2302 C  CD2 . PHE A 1 318 ? -14.661 11.354  28.940  1.00 16.59 ? 323 PHE A CD2 1 
ATOM   2303 C  CE1 . PHE A 1 318 ? -12.179 12.482  29.525  1.00 15.27 ? 323 PHE A CE1 1 
ATOM   2304 C  CE2 . PHE A 1 318 ? -14.356 12.626  28.477  1.00 16.85 ? 323 PHE A CE2 1 
ATOM   2305 C  CZ  . PHE A 1 318 ? -13.109 13.206  28.779  1.00 17.64 ? 323 PHE A CZ  1 
ATOM   2306 N  N   . GLY A 1 319 ? -13.140 5.779   29.351  1.00 16.32 ? 324 GLY A N   1 
ATOM   2307 C  CA  . GLY A 1 319 ? -12.847 4.443   29.854  1.00 17.17 ? 324 GLY A CA  1 
ATOM   2308 C  C   . GLY A 1 319 ? -13.902 3.365   29.649  1.00 18.53 ? 324 GLY A C   1 
ATOM   2309 O  O   . GLY A 1 319 ? -13.619 2.202   29.902  1.00 18.21 ? 324 GLY A O   1 
ATOM   2310 N  N   . GLN A 1 320 ? -15.102 3.716   29.197  1.00 18.90 ? 325 GLN A N   1 
ATOM   2311 C  CA  . GLN A 1 320 ? -16.082 2.684   28.903  1.00 22.46 ? 325 GLN A CA  1 
ATOM   2312 C  C   . GLN A 1 320 ? -15.509 1.834   27.733  1.00 23.51 ? 325 GLN A C   1 
ATOM   2313 O  O   . GLN A 1 320 ? -14.991 2.372   26.767  1.00 22.84 ? 325 GLN A O   1 
ATOM   2314 C  CB  . GLN A 1 320 ? -17.426 3.291   28.518  1.00 22.48 ? 325 GLN A CB  1 
ATOM   2315 C  CG  . GLN A 1 320 ? -18.491 2.274   28.028  1.00 26.72 ? 325 GLN A CG  1 
ATOM   2316 C  CD  . GLN A 1 320 ? -19.845 2.930   27.778  1.00 31.09 ? 325 GLN A CD  1 
ATOM   2317 O  OE1 . GLN A 1 320 ? -20.361 2.958   26.643  1.00 32.80 ? 325 GLN A OE1 1 
ATOM   2318 N  NE2 . GLN A 1 320 ? -20.415 3.480   28.828  1.00 31.17 ? 325 GLN A NE2 1 
ATOM   2319 N  N   . THR A 1 321 ? -15.549 0.520   27.888  1.00 26.03 ? 326 THR A N   1 
ATOM   2320 C  CA  . THR A 1 321 ? -15.127 -0.404  26.825  1.00 28.68 ? 326 THR A CA  1 
ATOM   2321 C  C   . THR A 1 321 ? -16.153 -1.527  26.623  1.00 28.71 ? 326 THR A C   1 
ATOM   2322 O  O   . THR A 1 321 ? -17.072 -1.693  27.415  1.00 29.49 ? 326 THR A O   1 
ATOM   2323 C  CB  . THR A 1 321 ? -13.796 -1.085  27.148  1.00 29.35 ? 326 THR A CB  1 
ATOM   2324 O  OG1 . THR A 1 321 ? -13.483 -2.005  26.075  1.00 34.69 ? 326 THR A OG1 1 
ATOM   2325 C  CG2 . THR A 1 321 ? -13.900 -1.852  28.448  1.00 28.93 ? 326 THR A CG2 1 
ATOM   2326 N  N   . ARG A 1 322 ? -15.964 -2.294  25.558  1.00 29.22 ? 327 ARG A N   1 
ATOM   2327 C  CA  . ARG A 1 322 ? -16.826 -3.420  25.234  1.00 28.91 ? 327 ARG A CA  1 
ATOM   2328 C  C   . ARG A 1 322 ? -16.582 -4.594  26.201  1.00 29.90 ? 327 ARG A C   1 
ATOM   2329 O  O   . ARG A 1 322 ? -17.478 -5.374  26.458  1.00 29.69 ? 327 ARG A O   1 
ATOM   2330 C  CB  . ARG A 1 322 ? -16.607 -3.834  23.784  1.00 28.03 ? 327 ARG A CB  1 
ATOM   2331 C  CG  . ARG A 1 322 ? -17.690 -3.352  22.755  1.00 27.27 ? 327 ARG A CG  1 
ATOM   2332 C  CD  . ARG A 1 322 ? -17.497 -1.924  22.208  1.00 19.14 ? 327 ARG A CD  1 
ATOM   2333 N  NE  . ARG A 1 322 ? -16.175 -1.676  21.643  1.00 13.47 ? 327 ARG A NE  1 
ATOM   2334 C  CZ  . ARG A 1 322 ? -15.832 -1.928  20.382  1.00 16.85 ? 327 ARG A CZ  1 
ATOM   2335 N  NH1 . ARG A 1 322 ? -16.724 -2.461  19.541  1.00 13.54 ? 327 ARG A NH1 1 
ATOM   2336 N  NH2 . ARG A 1 322 ? -14.597 -1.678  19.961  1.00 12.14 ? 327 ARG A NH2 1 
ATOM   2337 N  N   . GLU A 1 323 ? -15.375 -4.680  26.752  1.00 31.14 ? 328 GLU A N   1 
ATOM   2338 C  CA  . GLU A 1 323 ? -14.921 -5.810  27.576  1.00 32.71 ? 328 GLU A CA  1 
ATOM   2339 C  C   . GLU A 1 323 ? -15.159 -5.711  29.107  1.00 33.69 ? 328 GLU A C   1 
ATOM   2340 O  O   . GLU A 1 323 ? -14.924 -6.681  29.837  1.00 33.49 ? 328 GLU A O   1 
ATOM   2341 C  CB  . GLU A 1 323 ? -13.425 -6.052  27.302  1.00 32.78 ? 328 GLU A CB  1 
ATOM   2342 C  CG  . GLU A 1 323 ? -13.111 -6.083  25.797  1.00 33.34 ? 328 GLU A CG  1 
ATOM   2343 C  CD  . GLU A 1 323 ? -11.661 -6.434  25.453  1.00 32.99 ? 328 GLU A CD  1 
ATOM   2344 O  OE1 . GLU A 1 323 ? -10.856 -6.629  26.405  1.00 35.74 ? 328 GLU A OE1 1 
ATOM   2345 O  OE2 . GLU A 1 323 ? -11.345 -6.508  24.230  1.00 27.15 ? 328 GLU A OE2 1 
ATOM   2346 N  N   . GLY A 1 324 ? -15.588 -4.542  29.588  1.00 34.21 ? 329 GLY A N   1 
ATOM   2347 C  CA  . GLY A 1 324 ? -15.930 -4.367  31.014  1.00 34.39 ? 329 GLY A CA  1 
ATOM   2348 C  C   . GLY A 1 324 ? -14.780 -4.364  32.019  1.00 33.41 ? 329 GLY A C   1 
ATOM   2349 O  O   . GLY A 1 324 ? -14.949 -4.800  33.169  1.00 34.75 ? 329 GLY A O   1 
ATOM   2350 N  N   . GLY A 1 325 ? -13.614 -3.874  31.612  1.00 32.73 ? 330 GLY A N   1 
ATOM   2351 C  CA  . GLY A 1 325 ? -12.485 -3.784  32.537  1.00 31.60 ? 330 GLY A CA  1 
ATOM   2352 C  C   . GLY A 1 325 ? -12.268 -2.436  33.230  1.00 31.43 ? 330 GLY A C   1 
ATOM   2353 O  O   . GLY A 1 325 ? -11.289 -2.279  33.970  1.00 31.73 ? 330 GLY A O   1 
ATOM   2354 N  N   . HIS A 1 326 ? -13.158 -1.474  33.006  1.00 30.31 ? 331 HIS A N   1 
ATOM   2355 C  CA  A HIS A 1 326 ? -12.910 -0.162  33.585  0.50 30.64 ? 331 HIS A CA  1 
ATOM   2356 C  CA  B HIS A 1 326 ? -13.031 -0.118  33.548  0.50 31.06 ? 331 HIS A CA  1 
ATOM   2357 C  C   . HIS A 1 326 ? -13.222 -0.077  35.069  1.00 31.19 ? 331 HIS A C   1 
ATOM   2358 O  O   . HIS A 1 326 ? -12.458 0.557   35.798  1.00 30.80 ? 331 HIS A O   1 
ATOM   2359 C  CB  A HIS A 1 326 ? -13.550 0.993   32.834  0.50 29.99 ? 331 HIS A CB  1 
ATOM   2360 C  CB  B HIS A 1 326 ? -14.005 0.841   32.846  0.50 30.80 ? 331 HIS A CB  1 
ATOM   2361 C  CG  A HIS A 1 326 ? -13.089 2.328   33.331  0.50 28.89 ? 331 HIS A CG  1 
ATOM   2362 C  CG  B HIS A 1 326 ? -15.290 0.204   32.391  0.50 31.63 ? 331 HIS A CG  1 
ATOM   2363 N  ND1 A HIS A 1 326 ? -11.809 2.791   33.124  0.50 27.63 ? 331 HIS A ND1 1 
ATOM   2364 N  ND1 B HIS A 1 326 ? -15.485 -0.246  31.100  0.50 31.96 ? 331 HIS A ND1 1 
ATOM   2365 C  CD2 A HIS A 1 326 ? -13.711 3.266   34.082  0.50 27.32 ? 331 HIS A CD2 1 
ATOM   2366 C  CD2 B HIS A 1 326 ? -16.441 -0.052  33.053  0.50 31.52 ? 331 HIS A CD2 1 
ATOM   2367 C  CE1 A HIS A 1 326 ? -11.674 3.975   33.694  0.50 27.44 ? 331 HIS A CE1 1 
ATOM   2368 C  CE1 B HIS A 1 326 ? -16.705 -0.741  30.987  0.50 31.94 ? 331 HIS A CE1 1 
ATOM   2369 N  NE2 A HIS A 1 326 ? -12.816 4.288   34.277  0.50 26.58 ? 331 HIS A NE2 1 
ATOM   2370 N  NE2 B HIS A 1 326 ? -17.306 -0.635  32.159  0.50 32.35 ? 331 HIS A NE2 1 
ATOM   2371 N  N   . ILE A 1 327 ? -14.286 -0.743  35.507  1.00 31.72 ? 332 ILE A N   1 
ATOM   2372 C  CA  . ILE A 1 327 ? -14.544 -0.935  36.914  1.00 33.29 ? 332 ILE A CA  1 
ATOM   2373 C  C   . ILE A 1 327 ? -13.703 -2.098  37.399  1.00 34.37 ? 332 ILE A C   1 
ATOM   2374 O  O   . ILE A 1 327 ? -13.752 -3.181  36.805  1.00 34.33 ? 332 ILE A O   1 
ATOM   2375 C  CB  . ILE A 1 327 ? -16.037 -1.187  37.196  1.00 32.82 ? 332 ILE A CB  1 
ATOM   2376 C  CG1 . ILE A 1 327 ? -16.801 0.134   37.139  1.00 32.40 ? 332 ILE A CG1 1 
ATOM   2377 C  CG2 . ILE A 1 327 ? -16.215 -1.809  38.588  1.00 32.53 ? 332 ILE A CG2 1 
ATOM   2378 C  CD1 . ILE A 1 327 ? -17.296 0.540   35.779  1.00 31.22 ? 332 ILE A CD1 1 
ATOM   2379 N  N   . VAL A 1 328 ? -12.921 -1.860  38.458  1.00 35.01 ? 333 VAL A N   1 
ATOM   2380 C  CA  . VAL A 1 328 ? -12.027 -2.864  39.044  1.00 36.49 ? 333 VAL A CA  1 
ATOM   2381 C  C   . VAL A 1 328 ? -12.759 -3.669  40.114  1.00 38.11 ? 333 VAL A C   1 
ATOM   2382 O  O   . VAL A 1 328 ? -13.407 -3.117  41.020  1.00 37.78 ? 333 VAL A O   1 
ATOM   2383 C  CB  . VAL A 1 328 ? -10.729 -2.229  39.621  1.00 36.80 ? 333 VAL A CB  1 
ATOM   2384 C  CG1 . VAL A 1 328 ? -9.987  -3.173  40.595  1.00 37.15 ? 333 VAL A CG1 1 
ATOM   2385 C  CG2 . VAL A 1 328 ? -9.811  -1.785  38.500  1.00 37.28 ? 333 VAL A CG2 1 
ATOM   2386 N  N   . TYR A 1 329 ? -12.671 -4.984  39.980  1.00 39.03 ? 334 TYR A N   1 
ATOM   2387 C  CA  . TYR A 1 329 ? -13.336 -5.881  40.895  1.00 40.59 ? 334 TYR A CA  1 
ATOM   2388 C  C   . TYR A 1 329 ? -12.242 -6.521  41.707  1.00 41.96 ? 334 TYR A C   1 
ATOM   2389 O  O   . TYR A 1 329 ? -11.194 -6.887  41.174  1.00 42.19 ? 334 TYR A O   1 
ATOM   2390 C  CB  . TYR A 1 329 ? -14.137 -6.916  40.129  1.00 40.09 ? 334 TYR A CB  1 
ATOM   2391 C  CG  . TYR A 1 329 ? -15.057 -7.743  40.980  1.00 40.32 ? 334 TYR A CG  1 
ATOM   2392 C  CD1 . TYR A 1 329 ? -16.357 -7.329  41.242  1.00 38.82 ? 334 TYR A CD1 1 
ATOM   2393 C  CD2 . TYR A 1 329 ? -14.629 -8.964  41.508  1.00 40.13 ? 334 TYR A CD2 1 
ATOM   2394 C  CE1 . TYR A 1 329 ? -17.205 -8.105  42.019  1.00 39.97 ? 334 TYR A CE1 1 
ATOM   2395 C  CE2 . TYR A 1 329 ? -15.472 -9.748  42.279  1.00 40.16 ? 334 TYR A CE2 1 
ATOM   2396 C  CZ  . TYR A 1 329 ? -16.752 -9.309  42.538  1.00 40.12 ? 334 TYR A CZ  1 
ATOM   2397 O  OH  . TYR A 1 329 ? -17.582 -10.097 43.306  1.00 42.69 ? 334 TYR A OH  1 
ATOM   2398 N  N   . ASP A 1 330 ? -12.512 -6.649  43.002  1.00 43.69 ? 335 ASP A N   1 
ATOM   2399 C  CA  . ASP A 1 330 ? -11.513 -6.936  44.024  1.00 45.20 ? 335 ASP A CA  1 
ATOM   2400 C  C   . ASP A 1 330 ? -11.282 -8.436  44.253  1.00 45.27 ? 335 ASP A C   1 
ATOM   2401 O  O   . ASP A 1 330 ? -10.178 -8.949  44.019  1.00 45.03 ? 335 ASP A O   1 
ATOM   2402 C  CB  . ASP A 1 330 ? -11.959 -6.250  45.329  1.00 45.93 ? 335 ASP A CB  1 
ATOM   2403 C  CG  . ASP A 1 330 ? -11.030 -6.528  46.490  1.00 48.34 ? 335 ASP A CG  1 
ATOM   2404 O  OD1 . ASP A 1 330 ? -9.966  -7.179  46.295  1.00 52.15 ? 335 ASP A OD1 1 
ATOM   2405 O  OD2 . ASP A 1 330 ? -11.364 -6.083  47.610  1.00 49.99 ? 335 ASP A OD2 1 
ATOM   2406 N  N   . GLN A 1 331 ? -12.326 -9.112  44.739  1.00 45.25 ? 336 GLN A N   1 
ATOM   2407 C  CA  . GLN A 1 331 ? -12.311 -10.543 45.019  1.00 45.45 ? 336 GLN A CA  1 
ATOM   2408 C  C   . GLN A 1 331 ? -13.721 -11.094 44.924  1.00 44.66 ? 336 GLN A C   1 
ATOM   2409 O  O   . GLN A 1 331 ? -14.695 -10.387 45.191  1.00 44.36 ? 336 GLN A O   1 
ATOM   2410 C  CB  . GLN A 1 331 ? -11.746 -10.828 46.417  1.00 46.06 ? 336 GLN A CB  1 
ATOM   2411 C  CG  . GLN A 1 331 ? -10.333 -11.419 46.407  1.00 48.92 ? 336 GLN A CG  1 
ATOM   2412 C  CD  . GLN A 1 331 ? -9.607  -11.273 47.753  1.00 51.46 ? 336 GLN A CD  1 
ATOM   2413 O  OE1 . GLN A 1 331 ? -9.325  -12.267 48.428  1.00 53.53 ? 336 GLN A OE1 1 
ATOM   2414 N  NE2 . GLN A 1 331 ? -9.297  -10.034 48.135  1.00 52.12 ? 336 GLN A NE2 1 
ATOM   2415 N  N   . LEU A 1 332 ? -13.819 -12.357 44.526  1.00 44.18 ? 337 LEU A N   1 
ATOM   2416 C  CA  . LEU A 1 332 ? -15.082 -13.065 44.487  1.00 44.06 ? 337 LEU A CA  1 
ATOM   2417 C  C   . LEU A 1 332 ? -15.523 -13.439 45.903  1.00 44.38 ? 337 LEU A C   1 
ATOM   2418 O  O   . LEU A 1 332 ? -14.689 -13.835 46.729  1.00 44.21 ? 337 LEU A O   1 
ATOM   2419 C  CB  . LEU A 1 332 ? -14.937 -14.345 43.660  1.00 43.90 ? 337 LEU A CB  1 
ATOM   2420 C  CG  . LEU A 1 332 ? -14.623 -14.154 42.174  1.00 44.16 ? 337 LEU A CG  1 
ATOM   2421 C  CD1 . LEU A 1 332 ? -14.254 -15.473 41.537  1.00 43.16 ? 337 LEU A CD1 1 
ATOM   2422 C  CD2 . LEU A 1 332 ? -15.796 -13.487 41.441  1.00 43.37 ? 337 LEU A CD2 1 
ATOM   2423 N  N   . PRO A 1 333 ? -16.833 -13.325 46.183  1.00 44.51 ? 338 PRO A N   1 
ATOM   2424 C  CA  . PRO A 1 333 ? -17.327 -13.847 47.448  1.00 45.05 ? 338 PRO A CA  1 
ATOM   2425 C  C   . PRO A 1 333 ? -17.153 -15.361 47.469  1.00 45.43 ? 338 PRO A C   1 
ATOM   2426 O  O   . PRO A 1 333 ? -17.037 -15.991 46.411  1.00 45.52 ? 338 PRO A O   1 
ATOM   2427 C  CB  . PRO A 1 333 ? -18.816 -13.479 47.429  1.00 45.05 ? 338 PRO A CB  1 
ATOM   2428 C  CG  . PRO A 1 333 ? -18.953 -12.427 46.371  1.00 44.66 ? 338 PRO A CG  1 
ATOM   2429 C  CD  . PRO A 1 333 ? -17.906 -12.717 45.374  1.00 44.25 ? 338 PRO A CD  1 
ATOM   2430 N  N   . THR A 1 334 ? -17.097 -15.933 48.665  1.00 45.73 ? 339 THR A N   1 
ATOM   2431 C  CA  . THR A 1 334 ? -17.093 -17.386 48.822  1.00 46.03 ? 339 THR A CA  1 
ATOM   2432 C  C   . THR A 1 334 ? -18.348 -17.788 49.604  1.00 45.83 ? 339 THR A C   1 
ATOM   2433 O  O   . THR A 1 334 ? -18.902 -16.960 50.333  1.00 45.66 ? 339 THR A O   1 
ATOM   2434 C  CB  . THR A 1 334 ? -15.809 -17.871 49.495  1.00 46.10 ? 339 THR A CB  1 
ATOM   2435 O  OG1 . THR A 1 334 ? -15.489 -16.988 50.574  1.00 47.73 ? 339 THR A OG1 1 
ATOM   2436 C  CG2 . THR A 1 334 ? -14.659 -17.836 48.507  1.00 46.58 ? 339 THR A CG2 1 
ATOM   2437 N  N   . PRO A 1 335 ? -18.844 -19.031 49.407  1.00 45.74 ? 340 PRO A N   1 
ATOM   2438 C  CA  . PRO A 1 335 ? -20.053 -19.434 50.145  1.00 45.61 ? 340 PRO A CA  1 
ATOM   2439 C  C   . PRO A 1 335 ? -19.823 -19.564 51.652  1.00 45.15 ? 340 PRO A C   1 
ATOM   2440 O  O   . PRO A 1 335 ? -18.671 -19.659 52.086  1.00 44.75 ? 340 PRO A O   1 
ATOM   2441 C  CB  . PRO A 1 335 ? -20.419 -20.797 49.530  1.00 45.42 ? 340 PRO A CB  1 
ATOM   2442 C  CG  . PRO A 1 335 ? -19.238 -21.238 48.779  1.00 45.86 ? 340 PRO A CG  1 
ATOM   2443 C  CD  . PRO A 1 335 ? -18.473 -20.016 48.373  1.00 45.73 ? 340 PRO A CD  1 
ATOM   2444 N  N   . VAL B 1 18  ? -22.457 -35.946 5.363   1.00 37.98 ? 23  VAL B N   1 
ATOM   2445 C  CA  . VAL B 1 18  ? -23.815 -36.420 5.781   1.00 37.07 ? 23  VAL B CA  1 
ATOM   2446 C  C   . VAL B 1 18  ? -23.900 -36.443 7.311   1.00 36.44 ? 23  VAL B C   1 
ATOM   2447 O  O   . VAL B 1 18  ? -23.371 -37.338 7.994   1.00 37.06 ? 23  VAL B O   1 
ATOM   2448 C  CB  . VAL B 1 18  ? -24.166 -37.788 5.177   1.00 37.55 ? 23  VAL B CB  1 
ATOM   2449 C  CG1 . VAL B 1 18  ? -25.602 -38.199 5.546   1.00 37.72 ? 23  VAL B CG1 1 
ATOM   2450 C  CG2 . VAL B 1 18  ? -24.012 -37.756 3.643   1.00 37.87 ? 23  VAL B CG2 1 
ATOM   2451 N  N   . HIS B 1 19  ? -24.583 -35.451 7.849   1.00 34.96 ? 24  HIS B N   1 
ATOM   2452 C  CA  . HIS B 1 19  ? -24.629 -35.289 9.278   1.00 33.54 ? 24  HIS B CA  1 
ATOM   2453 C  C   . HIS B 1 19  ? -25.906 -35.916 9.800   1.00 32.06 ? 24  HIS B C   1 
ATOM   2454 O  O   . HIS B 1 19  ? -26.969 -35.753 9.201   1.00 32.91 ? 24  HIS B O   1 
ATOM   2455 C  CB  . HIS B 1 19  ? -24.568 -33.794 9.631   1.00 33.48 ? 24  HIS B CB  1 
ATOM   2456 C  CG  . HIS B 1 19  ? -23.456 -33.057 8.947   1.00 34.85 ? 24  HIS B CG  1 
ATOM   2457 N  ND1 . HIS B 1 19  ? -22.128 -33.237 9.276   1.00 35.62 ? 24  HIS B ND1 1 
ATOM   2458 C  CD2 . HIS B 1 19  ? -23.476 -32.132 7.957   1.00 34.75 ? 24  HIS B CD2 1 
ATOM   2459 C  CE1 . HIS B 1 19  ? -21.379 -32.459 8.515   1.00 36.51 ? 24  HIS B CE1 1 
ATOM   2460 N  NE2 . HIS B 1 19  ? -22.171 -31.784 7.702   1.00 36.83 ? 24  HIS B NE2 1 
ATOM   2461 N  N   . SER B 1 20  ? -25.803 -36.648 10.900  1.00 30.78 ? 25  SER B N   1 
ATOM   2462 C  CA  . SER B 1 20  ? -27.005 -37.068 11.631  1.00 29.90 ? 25  SER B CA  1 
ATOM   2463 C  C   . SER B 1 20  ? -27.271 -36.033 12.712  1.00 28.64 ? 25  SER B C   1 
ATOM   2464 O  O   . SER B 1 20  ? -26.447 -35.807 13.585  1.00 28.40 ? 25  SER B O   1 
ATOM   2465 C  CB  . SER B 1 20  ? -26.854 -38.454 12.232  1.00 29.49 ? 25  SER B CB  1 
ATOM   2466 O  OG  . SER B 1 20  ? -26.729 -39.415 11.201  1.00 29.87 ? 25  SER B OG  1 
ATOM   2467 N  N   . VAL B 1 21  ? -28.424 -35.383 12.617  1.00 27.69 ? 26  VAL B N   1 
ATOM   2468 C  CA  . VAL B 1 21  ? -28.723 -34.261 13.488  1.00 26.67 ? 26  VAL B CA  1 
ATOM   2469 C  C   . VAL B 1 21  ? -30.023 -34.500 14.265  1.00 26.49 ? 26  VAL B C   1 
ATOM   2470 O  O   . VAL B 1 21  ? -31.074 -34.755 13.670  1.00 26.17 ? 26  VAL B O   1 
ATOM   2471 C  CB  . VAL B 1 21  ? -28.811 -32.973 12.669  1.00 26.60 ? 26  VAL B CB  1 
ATOM   2472 C  CG1 . VAL B 1 21  ? -29.044 -31.753 13.574  1.00 25.37 ? 26  VAL B CG1 1 
ATOM   2473 C  CG2 . VAL B 1 21  ? -27.531 -32.814 11.797  1.00 25.77 ? 26  VAL B CG2 1 
ATOM   2474 N  N   . ALA B 1 22  ? -29.924 -34.410 15.585  1.00 26.02 ? 27  ALA B N   1 
ATOM   2475 C  CA  . ALA B 1 22  ? -31.065 -34.494 16.483  1.00 26.09 ? 27  ALA B CA  1 
ATOM   2476 C  C   . ALA B 1 22  ? -31.471 -33.083 16.919  1.00 26.43 ? 27  ALA B C   1 
ATOM   2477 O  O   . ALA B 1 22  ? -30.618 -32.275 17.299  1.00 27.37 ? 27  ALA B O   1 
ATOM   2478 C  CB  . ALA B 1 22  ? -30.707 -35.333 17.687  1.00 26.43 ? 27  ALA B CB  1 
ATOM   2479 N  N   . VAL B 1 23  ? -32.761 -32.786 16.849  1.00 25.31 ? 28  VAL B N   1 
ATOM   2480 C  CA  . VAL B 1 23  ? -33.275 -31.483 17.255  1.00 25.13 ? 28  VAL B CA  1 
ATOM   2481 C  C   . VAL B 1 23  ? -34.150 -31.654 18.515  1.00 25.91 ? 28  VAL B C   1 
ATOM   2482 O  O   . VAL B 1 23  ? -35.134 -32.423 18.515  1.00 24.00 ? 28  VAL B O   1 
ATOM   2483 C  CB  . VAL B 1 23  ? -34.077 -30.822 16.119  1.00 25.40 ? 28  VAL B CB  1 
ATOM   2484 C  CG1 . VAL B 1 23  ? -34.812 -29.557 16.610  1.00 26.33 ? 28  VAL B CG1 1 
ATOM   2485 C  CG2 . VAL B 1 23  ? -33.147 -30.483 14.901  1.00 24.25 ? 28  VAL B CG2 1 
ATOM   2486 N  N   . ILE B 1 24  ? -33.771 -30.936 19.573  1.00 26.21 ? 29  ILE B N   1 
ATOM   2487 C  CA  . ILE B 1 24  ? -34.474 -30.971 20.861  1.00 26.75 ? 29  ILE B CA  1 
ATOM   2488 C  C   . ILE B 1 24  ? -35.033 -29.565 21.138  1.00 27.58 ? 29  ILE B C   1 
ATOM   2489 O  O   . ILE B 1 24  ? -34.287 -28.589 21.158  1.00 27.14 ? 29  ILE B O   1 
ATOM   2490 C  CB  . ILE B 1 24  ? -33.525 -31.448 21.993  1.00 27.08 ? 29  ILE B CB  1 
ATOM   2491 C  CG1 . ILE B 1 24  ? -33.023 -32.858 21.713  1.00 25.79 ? 29  ILE B CG1 1 
ATOM   2492 C  CG2 . ILE B 1 24  ? -34.186 -31.372 23.406  1.00 27.60 ? 29  ILE B CG2 1 
ATOM   2493 C  CD1 . ILE B 1 24  ? -31.884 -33.299 22.649  1.00 28.78 ? 29  ILE B CD1 1 
ATOM   2494 N  N   . GLY B 1 25  ? -36.346 -29.452 21.284  1.00 27.75 ? 30  GLY B N   1 
ATOM   2495 C  CA  . GLY B 1 25  ? -36.924 -28.185 21.742  1.00 28.76 ? 30  GLY B CA  1 
ATOM   2496 C  C   . GLY B 1 25  ? -36.842 -28.134 23.260  1.00 29.76 ? 30  GLY B C   1 
ATOM   2497 O  O   . GLY B 1 25  ? -37.430 -28.984 23.935  1.00 29.38 ? 30  GLY B O   1 
ATOM   2498 N  N   . ALA B 1 26  ? -36.099 -27.169 23.805  1.00 30.49 ? 31  ALA B N   1 
ATOM   2499 C  CA  . ALA B 1 26  ? -36.013 -26.990 25.254  1.00 30.57 ? 31  ALA B CA  1 
ATOM   2500 C  C   . ALA B 1 26  ? -36.614 -25.644 25.687  1.00 31.34 ? 31  ALA B C   1 
ATOM   2501 O  O   . ALA B 1 26  ? -35.881 -24.666 25.836  1.00 31.45 ? 31  ALA B O   1 
ATOM   2502 C  CB  . ALA B 1 26  ? -34.585 -27.116 25.725  1.00 30.37 ? 31  ALA B CB  1 
ATOM   2503 N  N   . PRO B 1 27  ? -37.948 -25.593 25.891  1.00 32.00 ? 32  PRO B N   1 
ATOM   2504 C  CA  . PRO B 1 27  ? -38.630 -24.323 26.186  1.00 32.57 ? 32  PRO B CA  1 
ATOM   2505 C  C   . PRO B 1 27  ? -38.355 -23.772 27.592  1.00 33.20 ? 32  PRO B C   1 
ATOM   2506 O  O   . PRO B 1 27  ? -39.298 -23.589 28.378  1.00 33.87 ? 32  PRO B O   1 
ATOM   2507 C  CB  . PRO B 1 27  ? -40.128 -24.667 26.018  1.00 32.71 ? 32  PRO B CB  1 
ATOM   2508 C  CG  . PRO B 1 27  ? -40.186 -26.039 25.417  1.00 32.41 ? 32  PRO B CG  1 
ATOM   2509 C  CD  . PRO B 1 27  ? -38.902 -26.712 25.806  1.00 32.21 ? 32  PRO B CD  1 
ATOM   2510 N  N   . PHE B 1 28  ? -37.081 -23.534 27.913  1.00 33.14 ? 33  PHE B N   1 
ATOM   2511 C  CA  . PHE B 1 28  ? -36.693 -22.852 29.150  1.00 33.45 ? 33  PHE B CA  1 
ATOM   2512 C  C   . PHE B 1 28  ? -37.105 -21.376 29.156  1.00 33.20 ? 33  PHE B C   1 
ATOM   2513 O  O   . PHE B 1 28  ? -36.805 -20.636 28.219  1.00 32.64 ? 33  PHE B O   1 
ATOM   2514 C  CB  . PHE B 1 28  ? -35.175 -22.868 29.298  1.00 33.67 ? 33  PHE B CB  1 
ATOM   2515 C  CG  . PHE B 1 28  ? -34.621 -24.111 29.918  1.00 34.89 ? 33  PHE B CG  1 
ATOM   2516 C  CD1 . PHE B 1 28  ? -34.843 -25.358 29.351  1.00 36.56 ? 33  PHE B CD1 1 
ATOM   2517 C  CD2 . PHE B 1 28  ? -33.816 -24.024 31.045  1.00 36.13 ? 33  PHE B CD2 1 
ATOM   2518 C  CE1 . PHE B 1 28  ? -34.282 -26.510 29.929  1.00 37.82 ? 33  PHE B CE1 1 
ATOM   2519 C  CE2 . PHE B 1 28  ? -33.262 -25.149 31.632  1.00 36.37 ? 33  PHE B CE2 1 
ATOM   2520 C  CZ  . PHE B 1 28  ? -33.492 -26.401 31.072  1.00 37.20 ? 33  PHE B CZ  1 
ATOM   2521 N  N   . SER B 1 29  ? -37.746 -20.925 30.227  1.00 32.89 ? 34  SER B N   1 
ATOM   2522 C  CA  . SER B 1 29  ? -37.953 -19.489 30.389  1.00 32.47 ? 34  SER B CA  1 
ATOM   2523 C  C   . SER B 1 29  ? -37.563 -18.999 31.766  1.00 31.97 ? 34  SER B C   1 
ATOM   2524 O  O   . SER B 1 29  ? -37.402 -17.807 31.959  1.00 31.49 ? 34  SER B O   1 
ATOM   2525 C  CB  . SER B 1 29  ? -39.380 -19.061 30.027  1.00 32.52 ? 34  SER B CB  1 
ATOM   2526 O  OG  . SER B 1 29  ? -40.320 -19.528 30.984  1.00 34.80 ? 34  SER B OG  1 
ATOM   2527 N  N   . GLN B 1 30  ? -37.379 -19.925 32.708  1.00 32.09 ? 35  GLN B N   1 
ATOM   2528 C  CA  . GLN B 1 30  ? -37.229 -19.582 34.121  1.00 32.36 ? 35  GLN B CA  1 
ATOM   2529 C  C   . GLN B 1 30  ? -35.784 -19.241 34.515  1.00 31.85 ? 35  GLN B C   1 
ATOM   2530 O  O   . GLN B 1 30  ? -35.494 -18.968 35.687  1.00 32.18 ? 35  GLN B O   1 
ATOM   2531 C  CB  . GLN B 1 30  ? -37.856 -20.674 35.018  1.00 33.20 ? 35  GLN B CB  1 
ATOM   2532 C  CG  . GLN B 1 30  ? -39.355 -20.924 34.701  1.00 36.14 ? 35  GLN B CG  1 
ATOM   2533 C  CD  . GLN B 1 30  ? -40.069 -21.796 35.736  1.00 41.39 ? 35  GLN B CD  1 
ATOM   2534 O  OE1 . GLN B 1 30  ? -39.603 -21.967 36.866  1.00 44.95 ? 35  GLN B OE1 1 
ATOM   2535 N  NE2 . GLN B 1 30  ? -41.214 -22.332 35.355  1.00 43.58 ? 35  GLN B NE2 1 
ATOM   2536 N  N   . GLY B 1 31  ? -34.885 -19.219 33.530  1.00 31.06 ? 36  GLY B N   1 
ATOM   2537 C  CA  . GLY B 1 31  ? -33.528 -18.715 33.741  1.00 29.90 ? 36  GLY B CA  1 
ATOM   2538 C  C   . GLY B 1 31  ? -33.470 -17.195 33.696  1.00 29.89 ? 36  GLY B C   1 
ATOM   2539 O  O   . GLY B 1 31  ? -32.421 -16.605 33.948  1.00 29.70 ? 36  GLY B O   1 
ATOM   2540 N  N   . GLN B 1 32  ? -34.599 -16.574 33.369  1.00 30.25 ? 37  GLN B N   1 
ATOM   2541 C  CA  . GLN B 1 32  ? -34.742 -15.103 33.300  1.00 31.39 ? 37  GLN B CA  1 
ATOM   2542 C  C   . GLN B 1 32  ? -36.191 -14.695 33.564  1.00 32.42 ? 37  GLN B C   1 
ATOM   2543 O  O   . GLN B 1 32  ? -37.032 -15.552 33.835  1.00 32.07 ? 37  GLN B O   1 
ATOM   2544 C  CB  . GLN B 1 32  ? -34.245 -14.568 31.939  1.00 30.98 ? 37  GLN B CB  1 
ATOM   2545 C  CG  . GLN B 1 32  ? -34.820 -15.303 30.727  1.00 29.65 ? 37  GLN B CG  1 
ATOM   2546 C  CD  . GLN B 1 32  ? -36.174 -14.762 30.295  1.00 31.33 ? 37  GLN B CD  1 
ATOM   2547 O  OE1 . GLN B 1 32  ? -36.277 -13.638 29.779  1.00 30.24 ? 37  GLN B OE1 1 
ATOM   2548 N  NE2 . GLN B 1 32  ? -37.226 -15.565 30.493  1.00 30.55 ? 37  GLN B NE2 1 
ATOM   2549 N  N   . LYS B 1 33  ? -36.488 -13.399 33.458  1.00 33.45 ? 38  LYS B N   1 
ATOM   2550 C  CA  . LYS B 1 33  ? -37.797 -12.866 33.888  1.00 34.98 ? 38  LYS B CA  1 
ATOM   2551 C  C   . LYS B 1 33  ? -38.767 -12.508 32.784  1.00 35.57 ? 38  LYS B C   1 
ATOM   2552 O  O   . LYS B 1 33  ? -39.926 -12.188 33.067  1.00 36.04 ? 38  LYS B O   1 
ATOM   2553 C  CB  . LYS B 1 33  ? -37.619 -11.637 34.795  1.00 35.10 ? 38  LYS B CB  1 
ATOM   2554 C  CG  . LYS B 1 33  ? -36.925 -11.947 36.099  1.00 36.78 ? 38  LYS B CG  1 
ATOM   2555 C  CD  . LYS B 1 33  ? -37.292 -10.942 37.203  1.00 38.22 ? 38  LYS B CD  1 
ATOM   2556 C  CE  . LYS B 1 33  ? -36.495 -11.243 38.468  1.00 39.71 ? 38  LYS B CE  1 
ATOM   2557 N  NZ  . LYS B 1 33  ? -35.040 -11.207 38.195  1.00 41.01 ? 38  LYS B NZ  1 
ATOM   2558 N  N   . ARG B 1 34  ? -38.308 -12.532 31.535  1.00 35.88 ? 39  ARG B N   1 
ATOM   2559 C  CA  . ARG B 1 34  ? -39.155 -12.101 30.418  1.00 36.43 ? 39  ARG B CA  1 
ATOM   2560 C  C   . ARG B 1 34  ? -39.876 -13.266 29.743  1.00 36.19 ? 39  ARG B C   1 
ATOM   2561 O  O   . ARG B 1 34  ? -39.261 -14.158 29.164  1.00 36.39 ? 39  ARG B O   1 
ATOM   2562 C  CB  . ARG B 1 34  ? -38.359 -11.256 29.405  1.00 36.87 ? 39  ARG B CB  1 
ATOM   2563 C  CG  . ARG B 1 34  ? -37.735 -10.024 30.045  1.00 38.82 ? 39  ARG B CG  1 
ATOM   2564 C  CD  . ARG B 1 34  ? -38.030 -8.746  29.273  1.00 44.12 ? 39  ARG B CD  1 
ATOM   2565 N  NE  . ARG B 1 34  ? -36.867 -8.270  28.523  1.00 45.99 ? 39  ARG B NE  1 
ATOM   2566 C  CZ  . ARG B 1 34  ? -36.861 -7.190  27.740  1.00 47.45 ? 39  ARG B CZ  1 
ATOM   2567 N  NH1 . ARG B 1 34  ? -37.953 -6.443  27.596  1.00 47.78 ? 39  ARG B NH1 1 
ATOM   2568 N  NH2 . ARG B 1 34  ? -35.753 -6.851  27.097  1.00 48.38 ? 39  ARG B NH2 1 
ATOM   2569 N  N   . LYS B 1 35  ? -41.195 -13.256 29.840  1.00 35.60 ? 40  LYS B N   1 
ATOM   2570 C  CA  . LYS B 1 35  ? -42.012 -14.286 29.212  1.00 34.83 ? 40  LYS B CA  1 
ATOM   2571 C  C   . LYS B 1 35  ? -41.881 -14.281 27.681  1.00 33.27 ? 40  LYS B C   1 
ATOM   2572 O  O   . LYS B 1 35  ? -41.682 -13.220 27.060  1.00 32.00 ? 40  LYS B O   1 
ATOM   2573 C  CB  . LYS B 1 35  ? -43.474 -14.091 29.602  1.00 35.38 ? 40  LYS B CB  1 
ATOM   2574 C  CG  . LYS B 1 35  ? -43.955 -12.653 29.499  1.00 38.26 ? 40  LYS B CG  1 
ATOM   2575 C  CD  . LYS B 1 35  ? -44.918 -12.288 30.645  1.00 43.15 ? 40  LYS B CD  1 
ATOM   2576 C  CE  . LYS B 1 35  ? -44.163 -11.870 31.913  1.00 45.08 ? 40  LYS B CE  1 
ATOM   2577 N  NZ  . LYS B 1 35  ? -45.110 -11.567 33.038  1.00 46.46 ? 40  LYS B NZ  1 
ATOM   2578 N  N   . GLY B 1 36  ? -42.015 -15.472 27.092  1.00 31.91 ? 41  GLY B N   1 
ATOM   2579 C  CA  . GLY B 1 36  ? -42.080 -15.613 25.642  1.00 30.93 ? 41  GLY B CA  1 
ATOM   2580 C  C   . GLY B 1 36  ? -40.975 -16.480 25.084  1.00 30.25 ? 41  GLY B C   1 
ATOM   2581 O  O   . GLY B 1 36  ? -41.172 -17.155 24.079  1.00 30.10 ? 41  GLY B O   1 
ATOM   2582 N  N   . VAL B 1 37  ? -39.826 -16.484 25.766  1.00 29.82 ? 42  VAL B N   1 
ATOM   2583 C  CA  . VAL B 1 37  ? -38.644 -17.196 25.288  1.00 28.92 ? 42  VAL B CA  1 
ATOM   2584 C  C   . VAL B 1 37  ? -38.882 -18.708 25.168  1.00 29.43 ? 42  VAL B C   1 
ATOM   2585 O  O   . VAL B 1 37  ? -38.128 -19.394 24.495  1.00 28.84 ? 42  VAL B O   1 
ATOM   2586 C  CB  . VAL B 1 37  ? -37.384 -16.845 26.103  1.00 29.31 ? 42  VAL B CB  1 
ATOM   2587 C  CG1 . VAL B 1 37  ? -37.464 -17.412 27.532  1.00 28.16 ? 42  VAL B CG1 1 
ATOM   2588 C  CG2 . VAL B 1 37  ? -36.099 -17.324 25.381  1.00 26.12 ? 42  VAL B CG2 1 
ATOM   2589 N  N   . GLU B 1 38  ? -39.963 -19.211 25.785  1.00 29.52 ? 43  GLU B N   1 
ATOM   2590 C  CA  . GLU B 1 38  ? -40.277 -20.635 25.738  1.00 29.72 ? 43  GLU B CA  1 
ATOM   2591 C  C   . GLU B 1 38  ? -40.871 -20.998 24.393  1.00 29.55 ? 43  GLU B C   1 
ATOM   2592 O  O   . GLU B 1 38  ? -40.958 -22.177 24.046  1.00 30.63 ? 43  GLU B O   1 
ATOM   2593 C  CB  . GLU B 1 38  ? -41.240 -21.041 26.875  1.00 30.32 ? 43  GLU B CB  1 
ATOM   2594 C  CG  . GLU B 1 38  ? -42.674 -20.470 26.756  1.00 31.63 ? 43  GLU B CG  1 
ATOM   2595 C  CD  . GLU B 1 38  ? -42.839 -19.068 27.341  1.00 34.38 ? 43  GLU B CD  1 
ATOM   2596 O  OE1 . GLU B 1 38  ? -41.817 -18.392 27.577  1.00 34.07 ? 43  GLU B OE1 1 
ATOM   2597 O  OE2 . GLU B 1 38  ? -44.010 -18.626 27.560  1.00 34.82 ? 43  GLU B OE2 1 
ATOM   2598 N  N   . HIS B 1 39  ? -41.283 -19.985 23.647  1.00 29.28 ? 44  HIS B N   1 
ATOM   2599 C  CA  . HIS B 1 39  ? -41.835 -20.167 22.307  1.00 29.67 ? 44  HIS B CA  1 
ATOM   2600 C  C   . HIS B 1 39  ? -40.730 -20.039 21.223  1.00 29.27 ? 44  HIS B C   1 
ATOM   2601 O  O   . HIS B 1 39  ? -41.002 -20.134 20.013  1.00 29.34 ? 44  HIS B O   1 
ATOM   2602 C  CB  . HIS B 1 39  ? -42.945 -19.146 22.058  1.00 29.95 ? 44  HIS B CB  1 
ATOM   2603 C  CG  . HIS B 1 39  ? -44.090 -19.254 23.018  1.00 32.95 ? 44  HIS B CG  1 
ATOM   2604 N  ND1 . HIS B 1 39  ? -44.870 -20.390 23.125  1.00 36.44 ? 44  HIS B ND1 1 
ATOM   2605 C  CD2 . HIS B 1 39  ? -44.602 -18.361 23.897  1.00 34.29 ? 44  HIS B CD2 1 
ATOM   2606 C  CE1 . HIS B 1 39  ? -45.810 -20.192 24.034  1.00 36.35 ? 44  HIS B CE1 1 
ATOM   2607 N  NE2 . HIS B 1 39  ? -45.669 -18.969 24.516  1.00 36.40 ? 44  HIS B NE2 1 
ATOM   2608 N  N   . GLY B 1 40  ? -39.499 -19.819 21.673  1.00 28.59 ? 45  GLY B N   1 
ATOM   2609 C  CA  . GLY B 1 40  ? -38.351 -19.824 20.784  1.00 27.25 ? 45  GLY B CA  1 
ATOM   2610 C  C   . GLY B 1 40  ? -38.213 -21.095 19.946  1.00 26.81 ? 45  GLY B C   1 
ATOM   2611 O  O   . GLY B 1 40  ? -38.019 -21.005 18.743  1.00 26.61 ? 45  GLY B O   1 
ATOM   2612 N  N   . PRO B 1 41  ? -38.298 -22.291 20.576  1.00 26.39 ? 46  PRO B N   1 
ATOM   2613 C  CA  . PRO B 1 41  ? -38.120 -23.481 19.753  1.00 26.61 ? 46  PRO B CA  1 
ATOM   2614 C  C   . PRO B 1 41  ? -39.147 -23.632 18.642  1.00 26.79 ? 46  PRO B C   1 
ATOM   2615 O  O   . PRO B 1 41  ? -38.775 -24.111 17.573  1.00 27.00 ? 46  PRO B O   1 
ATOM   2616 C  CB  . PRO B 1 41  ? -38.186 -24.622 20.765  1.00 26.04 ? 46  PRO B CB  1 
ATOM   2617 C  CG  . PRO B 1 41  ? -37.763 -23.985 22.037  1.00 26.48 ? 46  PRO B CG  1 
ATOM   2618 C  CD  . PRO B 1 41  ? -38.335 -22.629 22.011  1.00 25.39 ? 46  PRO B CD  1 
ATOM   2619 N  N   . ALA B 1 42  ? -40.404 -23.228 18.889  1.00 27.72 ? 47  ALA B N   1 
ATOM   2620 C  CA  . ALA B 1 42  ? -41.469 -23.242 17.873  1.00 27.68 ? 47  ALA B CA  1 
ATOM   2621 C  C   . ALA B 1 42  ? -41.277 -22.212 16.754  1.00 27.50 ? 47  ALA B C   1 
ATOM   2622 O  O   . ALA B 1 42  ? -41.555 -22.516 15.591  1.00 27.45 ? 47  ALA B O   1 
ATOM   2623 C  CB  . ALA B 1 42  ? -42.866 -23.064 18.522  1.00 27.42 ? 47  ALA B CB  1 
ATOM   2624 N  N   . ALA B 1 43  ? -40.853 -20.995 17.116  1.00 26.94 ? 48  ALA B N   1 
ATOM   2625 C  CA  . ALA B 1 43  ? -40.542 -19.937 16.140  1.00 26.00 ? 48  ALA B CA  1 
ATOM   2626 C  C   . ALA B 1 43  ? -39.482 -20.387 15.121  1.00 25.78 ? 48  ALA B C   1 
ATOM   2627 O  O   . ALA B 1 43  ? -39.598 -20.107 13.920  1.00 26.00 ? 48  ALA B O   1 
ATOM   2628 C  CB  . ALA B 1 43  ? -40.075 -18.661 16.863  1.00 25.89 ? 48  ALA B CB  1 
ATOM   2629 N  N   . ILE B 1 44  ? -38.478 -21.108 15.606  1.00 25.80 ? 49  ILE B N   1 
ATOM   2630 C  CA  . ILE B 1 44  ? -37.384 -21.576 14.767  1.00 25.57 ? 49  ILE B CA  1 
ATOM   2631 C  C   . ILE B 1 44  ? -37.895 -22.674 13.819  1.00 26.73 ? 49  ILE B C   1 
ATOM   2632 O  O   . ILE B 1 44  ? -37.624 -22.639 12.610  1.00 26.32 ? 49  ILE B O   1 
ATOM   2633 C  CB  . ILE B 1 44  ? -36.151 -21.980 15.622  1.00 24.86 ? 49  ILE B CB  1 
ATOM   2634 C  CG1 . ILE B 1 44  ? -35.668 -20.775 16.468  1.00 23.52 ? 49  ILE B CG1 1 
ATOM   2635 C  CG2 . ILE B 1 44  ? -35.009 -22.508 14.734  1.00 25.14 ? 49  ILE B CG2 1 
ATOM   2636 C  CD1 . ILE B 1 44  ? -34.598 -21.099 17.521  1.00 22.27 ? 49  ILE B CD1 1 
ATOM   2637 N  N   . ARG B 1 45  ? -38.660 -23.626 14.371  1.00 27.31 ? 50  ARG B N   1 
ATOM   2638 C  CA  . ARG B 1 45  ? -39.320 -24.677 13.594  1.00 28.24 ? 50  ARG B CA  1 
ATOM   2639 C  C   . ARG B 1 45  ? -40.177 -24.059 12.511  1.00 28.75 ? 50  ARG B C   1 
ATOM   2640 O  O   . ARG B 1 45  ? -40.112 -24.472 11.374  1.00 29.96 ? 50  ARG B O   1 
ATOM   2641 C  CB  . ARG B 1 45  ? -40.205 -25.565 14.496  1.00 28.14 ? 50  ARG B CB  1 
ATOM   2642 C  CG  . ARG B 1 45  ? -39.438 -26.485 15.430  1.00 29.14 ? 50  ARG B CG  1 
ATOM   2643 C  CD  . ARG B 1 45  ? -40.325 -26.853 16.668  1.00 31.80 ? 50  ARG B CD  1 
ATOM   2644 N  NE  . ARG B 1 45  ? -39.610 -27.679 17.648  1.00 31.21 ? 50  ARG B NE  1 
ATOM   2645 C  CZ  . ARG B 1 45  ? -39.095 -28.860 17.339  1.00 30.60 ? 50  ARG B CZ  1 
ATOM   2646 N  NH1 . ARG B 1 45  ? -39.246 -29.305 16.105  1.00 30.23 ? 50  ARG B NH1 1 
ATOM   2647 N  NH2 . ARG B 1 45  ? -38.445 -29.588 18.246  1.00 31.47 ? 50  ARG B NH2 1 
ATOM   2648 N  N   . GLU B 1 46  ? -40.969 -23.059 12.865  1.00 29.92 ? 51  GLU B N   1 
ATOM   2649 C  CA  . GLU B 1 46  ? -41.863 -22.431 11.909  1.00 31.02 ? 51  GLU B CA  1 
ATOM   2650 C  C   . GLU B 1 46  ? -41.094 -21.755 10.774  1.00 30.86 ? 51  GLU B C   1 
ATOM   2651 O  O   . GLU B 1 46  ? -41.516 -21.823 9.620   1.00 31.69 ? 51  GLU B O   1 
ATOM   2652 C  CB  . GLU B 1 46  ? -42.796 -21.447 12.612  1.00 31.34 ? 51  GLU B CB  1 
ATOM   2653 C  CG  . GLU B 1 46  ? -43.911 -22.144 13.403  1.00 35.32 ? 51  GLU B CG  1 
ATOM   2654 C  CD  . GLU B 1 46  ? -44.518 -21.239 14.458  1.00 39.05 ? 51  GLU B CD  1 
ATOM   2655 O  OE1 . GLU B 1 46  ? -44.879 -20.075 14.131  1.00 40.83 ? 51  GLU B OE1 1 
ATOM   2656 O  OE2 . GLU B 1 46  ? -44.626 -21.693 15.617  1.00 40.98 ? 51  GLU B OE2 1 
ATOM   2657 N  N   . ALA B 1 47  ? -39.956 -21.143 11.112  1.00 30.48 ? 52  ALA B N   1 
ATOM   2658 C  CA  . ALA B 1 47  ? -39.026 -20.537 10.143  1.00 29.34 ? 52  ALA B CA  1 
ATOM   2659 C  C   . ALA B 1 47  ? -38.416 -21.562 9.180   1.00 28.62 ? 52  ALA B C   1 
ATOM   2660 O  O   . ALA B 1 47  ? -37.605 -21.214 8.332   1.00 28.63 ? 52  ALA B O   1 
ATOM   2661 C  CB  . ALA B 1 47  ? -37.916 -19.771 10.879  1.00 28.67 ? 52  ALA B CB  1 
ATOM   2662 N  N   . GLY B 1 48  ? -38.773 -22.829 9.344   1.00 28.29 ? 53  GLY B N   1 
ATOM   2663 C  CA  . GLY B 1 48  ? -38.489 -23.862 8.343   1.00 27.28 ? 53  GLY B CA  1 
ATOM   2664 C  C   . GLY B 1 48  ? -37.200 -24.631 8.585   1.00 26.80 ? 53  GLY B C   1 
ATOM   2665 O  O   . GLY B 1 48  ? -36.604 -25.135 7.629   1.00 26.39 ? 53  GLY B O   1 
ATOM   2666 N  N   . LEU B 1 49  ? -36.784 -24.732 9.851   1.00 26.26 ? 54  LEU B N   1 
ATOM   2667 C  CA  . LEU B 1 49  ? -35.532 -25.415 10.218  1.00 26.28 ? 54  LEU B CA  1 
ATOM   2668 C  C   . LEU B 1 49  ? -35.367 -26.801 9.624   1.00 26.63 ? 54  LEU B C   1 
ATOM   2669 O  O   . LEU B 1 49  ? -34.298 -27.125 9.120   1.00 27.77 ? 54  LEU B O   1 
ATOM   2670 C  CB  . LEU B 1 49  ? -35.331 -25.507 11.745  1.00 25.34 ? 54  LEU B CB  1 
ATOM   2671 C  CG  . LEU B 1 49  ? -34.103 -26.301 12.224  1.00 25.26 ? 54  LEU B CG  1 
ATOM   2672 C  CD1 . LEU B 1 49  ? -32.793 -25.652 11.748  1.00 27.38 ? 54  LEU B CD1 1 
ATOM   2673 C  CD2 . LEU B 1 49  ? -34.049 -26.529 13.753  1.00 24.86 ? 54  LEU B CD2 1 
ATOM   2674 N  N   . MET B 1 50  ? -36.389 -27.647 9.750   1.00 27.75 ? 55  MET B N   1 
ATOM   2675 C  CA  . MET B 1 50  ? -36.255 -29.047 9.313   1.00 28.14 ? 55  MET B CA  1 
ATOM   2676 C  C   . MET B 1 50  ? -36.122 -29.189 7.785   1.00 27.73 ? 55  MET B C   1 
ATOM   2677 O  O   . MET B 1 50  ? -35.243 -29.887 7.313   1.00 28.05 ? 55  MET B O   1 
ATOM   2678 C  CB  . MET B 1 50  ? -37.370 -29.926 9.908   1.00 27.92 ? 55  MET B CB  1 
ATOM   2679 C  CG  . MET B 1 50  ? -37.409 -29.885 11.471  1.00 29.79 ? 55  MET B CG  1 
ATOM   2680 S  SD  . MET B 1 50  ? -35.871 -30.392 12.319  1.00 31.53 ? 55  MET B SD  1 
ATOM   2681 C  CE  . MET B 1 50  ? -35.969 -32.153 12.075  1.00 32.30 ? 55  MET B CE  1 
ATOM   2682 N  N   . LYS B 1 51  ? -36.967 -28.496 7.029   1.00 29.13 ? 56  LYS B N   1 
ATOM   2683 C  CA  . LYS B 1 51  ? -36.819 -28.399 5.556   1.00 29.94 ? 56  LYS B CA  1 
ATOM   2684 C  C   . LYS B 1 51  ? -35.373 -28.004 5.170   1.00 29.45 ? 56  LYS B C   1 
ATOM   2685 O  O   . LYS B 1 51  ? -34.741 -28.665 4.335   1.00 29.18 ? 56  LYS B O   1 
ATOM   2686 C  CB  . LYS B 1 51  ? -37.850 -27.404 4.990   1.00 31.00 ? 56  LYS B CB  1 
ATOM   2687 C  CG  . LYS B 1 51  ? -38.003 -27.370 3.445   1.00 33.36 ? 56  LYS B CG  1 
ATOM   2688 C  CD  . LYS B 1 51  ? -38.733 -28.614 2.889   1.00 40.13 ? 56  LYS B CD  1 
ATOM   2689 C  CE  . LYS B 1 51  ? -38.760 -28.642 1.351   1.00 41.58 ? 56  LYS B CE  1 
ATOM   2690 N  NZ  . LYS B 1 51  ? -39.080 -30.002 0.836   1.00 44.07 ? 56  LYS B NZ  1 
ATOM   2691 N  N   . ARG B 1 52  ? -34.831 -26.968 5.823   1.00 28.47 ? 57  ARG B N   1 
ATOM   2692 C  CA  . ARG B 1 52  ? -33.449 -26.525 5.537   1.00 27.82 ? 57  ARG B CA  1 
ATOM   2693 C  C   . ARG B 1 52  ? -32.406 -27.610 5.820   1.00 27.25 ? 57  ARG B C   1 
ATOM   2694 O  O   . ARG B 1 52  ? -31.544 -27.893 4.981   1.00 26.83 ? 57  ARG B O   1 
ATOM   2695 C  CB  . ARG B 1 52  ? -33.082 -25.224 6.280   1.00 27.65 ? 57  ARG B CB  1 
ATOM   2696 C  CG  . ARG B 1 52  ? -31.777 -24.579 5.737   1.00 28.76 ? 57  ARG B CG  1 
ATOM   2697 C  CD  . ARG B 1 52  ? -32.075 -23.749 4.475   1.00 29.96 ? 57  ARG B CD  1 
ATOM   2698 N  NE  . ARG B 1 52  ? -32.958 -22.650 4.828   1.00 30.64 ? 57  ARG B NE  1 
ATOM   2699 C  CZ  . ARG B 1 52  ? -32.543 -21.540 5.435   1.00 29.94 ? 57  ARG B CZ  1 
ATOM   2700 N  NH1 . ARG B 1 52  ? -33.416 -20.612 5.762   1.00 29.65 ? 57  ARG B NH1 1 
ATOM   2701 N  NH2 . ARG B 1 52  ? -31.254 -21.365 5.711   1.00 28.95 ? 57  ARG B NH2 1 
ATOM   2702 N  N   . LEU B 1 53  ? -32.468 -28.217 6.996   1.00 26.44 ? 58  LEU B N   1 
ATOM   2703 C  CA  . LEU B 1 53  ? -31.500 -29.241 7.324   1.00 25.92 ? 58  LEU B CA  1 
ATOM   2704 C  C   . LEU B 1 53  ? -31.671 -30.486 6.431   1.00 26.74 ? 58  LEU B C   1 
ATOM   2705 O  O   . LEU B 1 53  ? -30.689 -31.166 6.173   1.00 26.31 ? 58  LEU B O   1 
ATOM   2706 C  CB  . LEU B 1 53  ? -31.570 -29.623 8.794   1.00 25.33 ? 58  LEU B CB  1 
ATOM   2707 C  CG  . LEU B 1 53  ? -31.171 -28.558 9.832   1.00 24.82 ? 58  LEU B CG  1 
ATOM   2708 C  CD1 . LEU B 1 53  ? -31.335 -29.160 11.207  1.00 21.45 ? 58  LEU B CD1 1 
ATOM   2709 C  CD2 . LEU B 1 53  ? -29.704 -28.066 9.628   1.00 22.18 ? 58  LEU B CD2 1 
ATOM   2710 N  N   . SER B 1 54  ? -32.910 -30.763 5.990   1.00 28.22 ? 59  SER B N   1 
ATOM   2711 C  CA  . SER B 1 54  ? -33.201 -31.862 5.036   1.00 29.81 ? 59  SER B CA  1 
ATOM   2712 C  C   . SER B 1 54  ? -32.618 -31.557 3.673   1.00 30.25 ? 59  SER B C   1 
ATOM   2713 O  O   . SER B 1 54  ? -32.102 -32.449 3.008   1.00 30.69 ? 59  SER B O   1 
ATOM   2714 C  CB  . SER B 1 54  ? -34.716 -32.084 4.847   1.00 30.12 ? 59  SER B CB  1 
ATOM   2715 O  OG  . SER B 1 54  ? -35.361 -32.222 6.101   1.00 33.58 ? 59  SER B OG  1 
ATOM   2716 N  N   . SER B 1 55  ? -32.694 -30.300 3.242   1.00 30.69 ? 60  SER B N   1 
ATOM   2717 C  CA  . SER B 1 55  ? -32.136 -29.995 1.936   1.00 30.97 ? 60  SER B CA  1 
ATOM   2718 C  C   . SER B 1 55  ? -30.593 -30.157 1.968   1.00 30.68 ? 60  SER B C   1 
ATOM   2719 O  O   . SER B 1 55  ? -29.955 -30.365 0.944   1.00 30.59 ? 60  SER B O   1 
ATOM   2720 C  CB  . SER B 1 55  ? -32.672 -28.677 1.365   1.00 30.91 ? 60  SER B CB  1 
ATOM   2721 O  OG  . SER B 1 55  ? -32.477 -27.563 2.231   1.00 35.07 ? 60  SER B OG  1 
ATOM   2722 N  N   . LEU B 1 56  ? -30.018 -30.157 3.167   1.00 30.54 ? 61  LEU B N   1 
ATOM   2723 C  CA  . LEU B 1 56  ? -28.575 -30.295 3.347   1.00 30.34 ? 61  LEU B CA  1 
ATOM   2724 C  C   . LEU B 1 56  ? -28.119 -31.731 3.417   1.00 30.91 ? 61  LEU B C   1 
ATOM   2725 O  O   . LEU B 1 56  ? -26.937 -31.995 3.665   1.00 31.95 ? 61  LEU B O   1 
ATOM   2726 C  CB  . LEU B 1 56  ? -28.099 -29.560 4.614   1.00 30.17 ? 61  LEU B CB  1 
ATOM   2727 C  CG  . LEU B 1 56  ? -28.206 -28.035 4.642   1.00 29.43 ? 61  LEU B CG  1 
ATOM   2728 C  CD1 . LEU B 1 56  ? -27.612 -27.520 5.958   1.00 29.38 ? 61  LEU B CD1 1 
ATOM   2729 C  CD2 . LEU B 1 56  ? -27.522 -27.378 3.447   1.00 27.22 ? 61  LEU B CD2 1 
ATOM   2730 N  N   . GLY B 1 57  ? -29.044 -32.667 3.216   1.00 31.23 ? 62  GLY B N   1 
ATOM   2731 C  CA  . GLY B 1 57  ? -28.700 -34.084 3.285   1.00 31.05 ? 62  GLY B CA  1 
ATOM   2732 C  C   . GLY B 1 57  ? -28.440 -34.644 4.676   1.00 31.16 ? 62  GLY B C   1 
ATOM   2733 O  O   . GLY B 1 57  ? -27.836 -35.724 4.804   1.00 31.45 ? 62  GLY B O   1 
ATOM   2734 N  N   . CYS B 1 58  ? -28.874 -33.923 5.719   1.00 29.75 ? 63  CYS B N   1 
ATOM   2735 C  CA  . CYS B 1 58  ? -28.785 -34.412 7.099   1.00 29.40 ? 63  CYS B CA  1 
ATOM   2736 C  C   . CYS B 1 58  ? -29.741 -35.593 7.360   1.00 28.92 ? 63  CYS B C   1 
ATOM   2737 O  O   . CYS B 1 58  ? -30.868 -35.596 6.875   1.00 29.01 ? 63  CYS B O   1 
ATOM   2738 C  CB  . CYS B 1 58  ? -29.134 -33.293 8.084   1.00 29.05 ? 63  CYS B CB  1 
ATOM   2739 S  SG  . CYS B 1 58  ? -27.916 -31.919 8.071   1.00 31.58 ? 63  CYS B SG  1 
ATOM   2740 N  N   . HIS B 1 59  ? -29.298 -36.561 8.146   1.00 28.48 ? 64  HIS B N   1 
ATOM   2741 C  CA  . HIS B 1 59  ? -30.225 -37.558 8.696   1.00 29.11 ? 64  HIS B CA  1 
ATOM   2742 C  C   . HIS B 1 59  ? -30.857 -36.988 9.973   1.00 29.07 ? 64  HIS B C   1 
ATOM   2743 O  O   . HIS B 1 59  ? -30.162 -36.752 10.968  1.00 28.93 ? 64  HIS B O   1 
ATOM   2744 C  CB  . HIS B 1 59  ? -29.523 -38.896 8.977   1.00 29.33 ? 64  HIS B CB  1 
ATOM   2745 C  CG  . HIS B 1 59  ? -30.445 -39.966 9.491   1.00 29.95 ? 64  HIS B CG  1 
ATOM   2746 N  ND1 . HIS B 1 59  ? -31.389 -40.580 8.694   1.00 32.00 ? 64  HIS B ND1 1 
ATOM   2747 C  CD2 . HIS B 1 59  ? -30.564 -40.532 10.717  1.00 30.97 ? 64  HIS B CD2 1 
ATOM   2748 C  CE1 . HIS B 1 59  ? -32.051 -41.478 9.407   1.00 31.87 ? 64  HIS B CE1 1 
ATOM   2749 N  NE2 . HIS B 1 59  ? -31.573 -41.464 10.641  1.00 31.54 ? 64  HIS B NE2 1 
ATOM   2750 N  N   . LEU B 1 60  ? -32.171 -36.764 9.938   1.00 28.30 ? 65  LEU B N   1 
ATOM   2751 C  CA  . LEU B 1 60  ? -32.824 -36.017 11.014  1.00 29.20 ? 65  LEU B CA  1 
ATOM   2752 C  C   . LEU B 1 60  ? -33.638 -36.842 12.019  1.00 28.88 ? 65  LEU B C   1 
ATOM   2753 O  O   . LEU B 1 60  ? -34.435 -37.720 11.637  1.00 27.77 ? 65  LEU B O   1 
ATOM   2754 C  CB  . LEU B 1 60  ? -33.771 -34.953 10.440  1.00 29.50 ? 65  LEU B CB  1 
ATOM   2755 C  CG  . LEU B 1 60  ? -33.328 -33.537 10.067  1.00 30.83 ? 65  LEU B CG  1 
ATOM   2756 C  CD1 . LEU B 1 60  ? -32.239 -32.961 11.017  1.00 31.10 ? 65  LEU B CD1 1 
ATOM   2757 C  CD2 . LEU B 1 60  ? -32.920 -33.465 8.618   1.00 32.53 ? 65  LEU B CD2 1 
ATOM   2758 N  N   . LYS B 1 61  ? -33.474 -36.505 13.301  1.00 28.39 ? 66  LYS B N   1 
ATOM   2759 C  CA  . LYS B 1 61  ? -34.446 -36.907 14.313  1.00 28.38 ? 66  LYS B CA  1 
ATOM   2760 C  C   . LYS B 1 61  ? -34.910 -35.679 15.092  1.00 28.63 ? 66  LYS B C   1 
ATOM   2761 O  O   . LYS B 1 61  ? -34.081 -34.916 15.601  1.00 27.87 ? 66  LYS B O   1 
ATOM   2762 C  CB  . LYS B 1 61  ? -33.876 -37.959 15.265  1.00 28.39 ? 66  LYS B CB  1 
ATOM   2763 C  CG  . LYS B 1 61  ? -34.912 -38.459 16.256  1.00 29.86 ? 66  LYS B CG  1 
ATOM   2764 C  CD  . LYS B 1 61  ? -34.384 -39.573 17.142  1.00 30.46 ? 66  LYS B CD  1 
ATOM   2765 C  CE  . LYS B 1 61  ? -35.356 -39.851 18.272  1.00 32.01 ? 66  LYS B CE  1 
ATOM   2766 N  NZ  . LYS B 1 61  ? -34.881 -40.948 19.156  1.00 32.55 ? 66  LYS B NZ  1 
ATOM   2767 N  N   . ASP B 1 62  ? -36.222 -35.501 15.172  1.00 27.69 ? 67  ASP B N   1 
ATOM   2768 C  CA  . ASP B 1 62  ? -36.804 -34.419 15.931  1.00 29.04 ? 67  ASP B CA  1 
ATOM   2769 C  C   . ASP B 1 62  ? -37.422 -35.004 17.199  1.00 29.89 ? 67  ASP B C   1 
ATOM   2770 O  O   . ASP B 1 62  ? -38.386 -35.785 17.138  1.00 29.57 ? 67  ASP B O   1 
ATOM   2771 C  CB  . ASP B 1 62  ? -37.849 -33.687 15.065  1.00 29.21 ? 67  ASP B CB  1 
ATOM   2772 C  CG  . ASP B 1 62  ? -38.428 -32.430 15.738  1.00 30.05 ? 67  ASP B CG  1 
ATOM   2773 O  OD1 . ASP B 1 62  ? -38.093 -32.105 16.889  1.00 30.24 ? 67  ASP B OD1 1 
ATOM   2774 O  OD2 . ASP B 1 62  ? -39.245 -31.764 15.080  1.00 31.70 ? 67  ASP B OD2 1 
ATOM   2775 N  N   . PHE B 1 63  ? -36.859 -34.643 18.347  1.00 30.51 ? 68  PHE B N   1 
ATOM   2776 C  CA  . PHE B 1 63  ? -37.359 -35.141 19.623  1.00 31.97 ? 68  PHE B CA  1 
ATOM   2777 C  C   . PHE B 1 63  ? -38.606 -34.378 20.058  1.00 32.96 ? 68  PHE B C   1 
ATOM   2778 O  O   . PHE B 1 63  ? -39.178 -34.674 21.103  1.00 33.87 ? 68  PHE B O   1 
ATOM   2779 C  CB  . PHE B 1 63  ? -36.285 -35.039 20.706  1.00 31.09 ? 68  PHE B CB  1 
ATOM   2780 C  CG  . PHE B 1 63  ? -35.253 -36.114 20.651  1.00 31.79 ? 68  PHE B CG  1 
ATOM   2781 C  CD1 . PHE B 1 63  ? -34.208 -36.055 19.728  1.00 30.10 ? 68  PHE B CD1 1 
ATOM   2782 C  CD2 . PHE B 1 63  ? -35.299 -37.181 21.549  1.00 30.47 ? 68  PHE B CD2 1 
ATOM   2783 C  CE1 . PHE B 1 63  ? -33.236 -37.054 19.690  1.00 32.17 ? 68  PHE B CE1 1 
ATOM   2784 C  CE2 . PHE B 1 63  ? -34.332 -38.184 21.528  1.00 32.17 ? 68  PHE B CE2 1 
ATOM   2785 C  CZ  . PHE B 1 63  ? -33.288 -38.125 20.596  1.00 34.14 ? 68  PHE B CZ  1 
ATOM   2786 N  N   . GLY B 1 64  ? -39.048 -33.425 19.244  1.00 34.27 ? 69  GLY B N   1 
ATOM   2787 C  CA  . GLY B 1 64  ? -40.130 -32.499 19.625  1.00 35.71 ? 69  GLY B CA  1 
ATOM   2788 C  C   . GLY B 1 64  ? -39.718 -31.571 20.764  1.00 36.88 ? 69  GLY B C   1 
ATOM   2789 O  O   . GLY B 1 64  ? -38.534 -31.510 21.130  1.00 36.33 ? 69  GLY B O   1 
ATOM   2790 N  N   . ASP B 1 65  ? -40.685 -30.854 21.337  1.00 37.60 ? 70  ASP B N   1 
ATOM   2791 C  CA  . ASP B 1 65  ? -40.392 -29.985 22.487  1.00 39.10 ? 70  ASP B CA  1 
ATOM   2792 C  C   . ASP B 1 65  ? -40.560 -30.735 23.816  1.00 39.99 ? 70  ASP B C   1 
ATOM   2793 O  O   . ASP B 1 65  ? -41.638 -31.267 24.115  1.00 39.40 ? 70  ASP B O   1 
ATOM   2794 C  CB  . ASP B 1 65  ? -41.267 -28.734 22.470  1.00 39.23 ? 70  ASP B CB  1 
ATOM   2795 C  CG  . ASP B 1 65  ? -41.021 -27.856 21.257  1.00 40.12 ? 70  ASP B CG  1 
ATOM   2796 O  OD1 . ASP B 1 65  ? -40.119 -28.162 20.453  1.00 39.86 ? 70  ASP B OD1 1 
ATOM   2797 O  OD2 . ASP B 1 65  ? -41.745 -26.849 21.099  1.00 42.04 ? 70  ASP B OD2 1 
ATOM   2798 N  N   . LEU B 1 66  ? -39.496 -30.770 24.612  1.00 40.90 ? 71  LEU B N   1 
ATOM   2799 C  CA  . LEU B 1 66  ? -39.552 -31.422 25.911  1.00 42.16 ? 71  LEU B CA  1 
ATOM   2800 C  C   . LEU B 1 66  ? -40.555 -30.774 26.869  1.00 43.01 ? 71  LEU B C   1 
ATOM   2801 O  O   . LEU B 1 66  ? -40.654 -29.550 26.970  1.00 42.53 ? 71  LEU B O   1 
ATOM   2802 C  CB  . LEU B 1 66  ? -38.174 -31.476 26.560  1.00 41.77 ? 71  LEU B CB  1 
ATOM   2803 C  CG  . LEU B 1 66  ? -37.074 -32.240 25.834  1.00 41.73 ? 71  LEU B CG  1 
ATOM   2804 C  CD1 . LEU B 1 66  ? -35.822 -32.166 26.669  1.00 41.16 ? 71  LEU B CD1 1 
ATOM   2805 C  CD2 . LEU B 1 66  ? -37.453 -33.698 25.551  1.00 42.61 ? 71  LEU B CD2 1 
ATOM   2806 N  N   . SER B 1 67  ? -41.313 -31.618 27.557  1.00 44.60 ? 72  SER B N   1 
ATOM   2807 C  CA  . SER B 1 67  ? -42.175 -31.153 28.632  1.00 46.15 ? 72  SER B CA  1 
ATOM   2808 C  C   . SER B 1 67  ? -41.450 -31.465 29.936  1.00 46.79 ? 72  SER B C   1 
ATOM   2809 O  O   . SER B 1 67  ? -41.291 -32.628 30.292  1.00 47.20 ? 72  SER B O   1 
ATOM   2810 C  CB  . SER B 1 67  ? -43.534 -31.855 28.573  1.00 46.15 ? 72  SER B CB  1 
ATOM   2811 O  OG  . SER B 1 67  ? -44.495 -31.154 29.352  1.00 47.55 ? 72  SER B OG  1 
ATOM   2812 N  N   . PHE B 1 68  ? -40.952 -30.431 30.609  1.00 48.02 ? 73  PHE B N   1 
ATOM   2813 C  CA  . PHE B 1 68  ? -40.262 -30.607 31.889  1.00 48.89 ? 73  PHE B CA  1 
ATOM   2814 C  C   . PHE B 1 68  ? -41.265 -30.667 33.045  1.00 49.61 ? 73  PHE B C   1 
ATOM   2815 O  O   . PHE B 1 68  ? -42.362 -30.113 32.963  1.00 49.46 ? 73  PHE B O   1 
ATOM   2816 C  CB  . PHE B 1 68  ? -39.239 -29.490 32.129  1.00 48.93 ? 73  PHE B CB  1 
ATOM   2817 C  CG  . PHE B 1 68  ? -38.235 -29.340 31.022  1.00 49.34 ? 73  PHE B CG  1 
ATOM   2818 C  CD1 . PHE B 1 68  ? -38.353 -28.305 30.102  1.00 48.71 ? 73  PHE B CD1 1 
ATOM   2819 C  CD2 . PHE B 1 68  ? -37.176 -30.244 30.889  1.00 49.08 ? 73  PHE B CD2 1 
ATOM   2820 C  CE1 . PHE B 1 68  ? -37.432 -28.166 29.067  1.00 48.30 ? 73  PHE B CE1 1 
ATOM   2821 C  CE2 . PHE B 1 68  ? -36.248 -30.115 29.854  1.00 49.02 ? 73  PHE B CE2 1 
ATOM   2822 C  CZ  . PHE B 1 68  ? -36.379 -29.076 28.943  1.00 48.73 ? 73  PHE B CZ  1 
ATOM   2823 N  N   . THR B 1 69  ? -40.875 -31.354 34.114  1.00 50.48 ? 74  THR B N   1 
ATOM   2824 C  CA  . THR B 1 69  ? -41.728 -31.508 35.294  1.00 51.39 ? 74  THR B CA  1 
ATOM   2825 C  C   . THR B 1 69  ? -41.768 -30.198 36.101  1.00 52.14 ? 74  THR B C   1 
ATOM   2826 O  O   . THR B 1 69  ? -40.730 -29.736 36.590  1.00 52.12 ? 74  THR B O   1 
ATOM   2827 C  CB  . THR B 1 69  ? -41.236 -32.679 36.173  1.00 51.40 ? 74  THR B CB  1 
ATOM   2828 O  OG1 . THR B 1 69  ? -40.908 -33.796 35.335  1.00 50.47 ? 74  THR B OG1 1 
ATOM   2829 C  CG2 . THR B 1 69  ? -42.306 -33.087 37.193  1.00 51.05 ? 74  THR B CG2 1 
ATOM   2830 N  N   . PRO B 1 70  ? -42.965 -29.591 36.238  1.00 52.94 ? 75  PRO B N   1 
ATOM   2831 C  CA  . PRO B 1 70  ? -43.045 -28.322 36.969  1.00 53.40 ? 75  PRO B CA  1 
ATOM   2832 C  C   . PRO B 1 70  ? -42.744 -28.476 38.459  1.00 53.68 ? 75  PRO B C   1 
ATOM   2833 O  O   . PRO B 1 70  ? -42.819 -29.588 38.999  1.00 53.81 ? 75  PRO B O   1 
ATOM   2834 C  CB  . PRO B 1 70  ? -44.497 -27.869 36.736  1.00 53.65 ? 75  PRO B CB  1 
ATOM   2835 C  CG  . PRO B 1 70  ? -44.930 -28.602 35.497  1.00 52.96 ? 75  PRO B CG  1 
ATOM   2836 C  CD  . PRO B 1 70  ? -44.261 -29.938 35.625  1.00 53.06 ? 75  PRO B CD  1 
ATOM   2837 N  N   . VAL B 1 71  ? -42.380 -27.360 39.092  1.00 54.02 ? 76  VAL B N   1 
ATOM   2838 C  CA  . VAL B 1 71  ? -42.006 -27.306 40.505  1.00 54.32 ? 76  VAL B CA  1 
ATOM   2839 C  C   . VAL B 1 71  ? -42.616 -26.050 41.122  1.00 54.44 ? 76  VAL B C   1 
ATOM   2840 O  O   . VAL B 1 71  ? -43.260 -26.108 42.169  1.00 54.76 ? 76  VAL B O   1 
ATOM   2841 C  CB  . VAL B 1 71  ? -40.458 -27.256 40.689  1.00 54.44 ? 76  VAL B CB  1 
ATOM   2842 C  CG1 . VAL B 1 71  ? -40.074 -27.367 42.168  1.00 54.74 ? 76  VAL B CG1 1 
ATOM   2843 C  CG2 . VAL B 1 71  ? -39.773 -28.349 39.885  1.00 54.01 ? 76  VAL B CG2 1 
ATOM   2844 N  N   . ASP B 1 75  ? -39.367 -21.149 45.542  1.00 54.09 ? 80  ASP B N   1 
ATOM   2845 C  CA  . ASP B 1 75  ? -38.887 -20.151 46.499  1.00 53.97 ? 80  ASP B CA  1 
ATOM   2846 C  C   . ASP B 1 75  ? -37.494 -19.645 46.140  1.00 53.67 ? 80  ASP B C   1 
ATOM   2847 O  O   . ASP B 1 75  ? -36.572 -20.446 45.905  1.00 54.04 ? 80  ASP B O   1 
ATOM   2848 C  CB  . ASP B 1 75  ? -38.862 -20.721 47.924  1.00 54.39 ? 80  ASP B CB  1 
ATOM   2849 C  CG  . ASP B 1 75  ? -40.253 -21.048 48.462  1.00 55.13 ? 80  ASP B CG  1 
ATOM   2850 O  OD1 . ASP B 1 75  ? -41.258 -20.461 47.997  1.00 55.67 ? 80  ASP B OD1 1 
ATOM   2851 O  OD2 . ASP B 1 75  ? -40.335 -21.902 49.368  1.00 56.79 ? 80  ASP B OD2 1 
ATOM   2852 N  N   . LEU B 1 76  ? -37.343 -18.319 46.113  1.00 52.80 ? 81  LEU B N   1 
ATOM   2853 C  CA  . LEU B 1 76  ? -36.056 -17.677 45.832  1.00 52.07 ? 81  LEU B CA  1 
ATOM   2854 C  C   . LEU B 1 76  ? -34.924 -18.249 46.675  1.00 51.46 ? 81  LEU B C   1 
ATOM   2855 O  O   . LEU B 1 76  ? -35.153 -18.783 47.763  1.00 51.43 ? 81  LEU B O   1 
ATOM   2856 C  CB  . LEU B 1 76  ? -36.138 -16.164 46.060  1.00 52.25 ? 81  LEU B CB  1 
ATOM   2857 C  CG  . LEU B 1 76  ? -36.974 -15.340 45.083  1.00 52.65 ? 81  LEU B CG  1 
ATOM   2858 C  CD1 . LEU B 1 76  ? -38.354 -15.057 45.673  1.00 52.78 ? 81  LEU B CD1 1 
ATOM   2859 C  CD2 . LEU B 1 76  ? -36.243 -14.040 44.769  1.00 52.77 ? 81  LEU B CD2 1 
ATOM   2860 N  N   . TYR B 1 77  ? -33.702 -18.133 46.166  1.00 50.45 ? 82  TYR B N   1 
ATOM   2861 C  CA  . TYR B 1 77  ? -32.516 -18.583 46.892  1.00 49.64 ? 82  TYR B CA  1 
ATOM   2862 C  C   . TYR B 1 77  ? -31.651 -17.401 47.359  1.00 49.14 ? 82  TYR B C   1 
ATOM   2863 O  O   . TYR B 1 77  ? -31.126 -16.639 46.530  1.00 48.89 ? 82  TYR B O   1 
ATOM   2864 C  CB  . TYR B 1 77  ? -31.702 -19.545 46.020  1.00 49.66 ? 82  TYR B CB  1 
ATOM   2865 C  CG  . TYR B 1 77  ? -30.418 -20.011 46.659  1.00 49.40 ? 82  TYR B CG  1 
ATOM   2866 C  CD1 . TYR B 1 77  ? -30.397 -21.137 47.485  1.00 48.46 ? 82  TYR B CD1 1 
ATOM   2867 C  CD2 . TYR B 1 77  ? -29.218 -19.325 46.437  1.00 49.10 ? 82  TYR B CD2 1 
ATOM   2868 C  CE1 . TYR B 1 77  ? -29.216 -21.570 48.078  1.00 48.73 ? 82  TYR B CE1 1 
ATOM   2869 C  CE2 . TYR B 1 77  ? -28.028 -19.749 47.028  1.00 49.40 ? 82  TYR B CE2 1 
ATOM   2870 C  CZ  . TYR B 1 77  ? -28.037 -20.875 47.843  1.00 48.75 ? 82  TYR B CZ  1 
ATOM   2871 O  OH  . TYR B 1 77  ? -26.867 -21.295 48.418  1.00 49.71 ? 82  TYR B OH  1 
ATOM   2872 N  N   . ASN B 1 78  ? -31.493 -17.269 48.682  1.00 48.37 ? 83  ASN B N   1 
ATOM   2873 C  CA  . ASN B 1 78  ? -30.858 -16.089 49.306  1.00 48.08 ? 83  ASN B CA  1 
ATOM   2874 C  C   . ASN B 1 78  ? -31.456 -14.774 48.833  1.00 47.44 ? 83  ASN B C   1 
ATOM   2875 O  O   . ASN B 1 78  ? -30.724 -13.806 48.590  1.00 47.65 ? 83  ASN B O   1 
ATOM   2876 C  CB  . ASN B 1 78  ? -29.335 -16.066 49.109  1.00 48.21 ? 83  ASN B CB  1 
ATOM   2877 C  CG  . ASN B 1 78  ? -28.621 -17.119 49.932  1.00 49.45 ? 83  ASN B CG  1 
ATOM   2878 O  OD1 . ASN B 1 78  ? -29.210 -17.747 50.824  1.00 50.45 ? 83  ASN B OD1 1 
ATOM   2879 N  ND2 . ASN B 1 78  ? -27.338 -17.329 49.629  1.00 50.08 ? 83  ASN B ND2 1 
ATOM   2880 N  N   . ASN B 1 79  ? -32.783 -14.759 48.685  1.00 46.82 ? 84  ASN B N   1 
ATOM   2881 C  CA  . ASN B 1 79  ? -33.543 -13.555 48.321  1.00 46.27 ? 84  ASN B CA  1 
ATOM   2882 C  C   . ASN B 1 79  ? -33.126 -12.895 46.996  1.00 45.74 ? 84  ASN B C   1 
ATOM   2883 O  O   . ASN B 1 79  ? -33.425 -11.721 46.761  1.00 45.91 ? 84  ASN B O   1 
ATOM   2884 C  CB  . ASN B 1 79  ? -33.526 -12.543 49.482  1.00 46.40 ? 84  ASN B CB  1 
ATOM   2885 C  CG  . ASN B 1 79  ? -34.795 -12.586 50.297  1.00 47.08 ? 84  ASN B CG  1 
ATOM   2886 O  OD1 . ASN B 1 79  ? -35.818 -12.012 49.902  1.00 48.19 ? 84  ASN B OD1 1 
ATOM   2887 N  ND2 . ASN B 1 79  ? -34.749 -13.273 51.434  1.00 47.34 ? 84  ASN B ND2 1 
ATOM   2888 N  N   . LEU B 1 80  ? -32.464 -13.673 46.134  1.00 44.71 ? 85  LEU B N   1 
ATOM   2889 C  CA  . LEU B 1 80  ? -31.884 -13.187 44.881  1.00 43.64 ? 85  LEU B CA  1 
ATOM   2890 C  C   . LEU B 1 80  ? -32.231 -14.161 43.727  1.00 43.15 ? 85  LEU B C   1 
ATOM   2891 O  O   . LEU B 1 80  ? -33.078 -13.831 42.883  1.00 42.97 ? 85  LEU B O   1 
ATOM   2892 C  CB  . LEU B 1 80  ? -30.364 -12.998 45.059  1.00 43.73 ? 85  LEU B CB  1 
ATOM   2893 C  CG  . LEU B 1 80  ? -29.389 -12.482 43.978  1.00 43.23 ? 85  LEU B CG  1 
ATOM   2894 C  CD1 . LEU B 1 80  ? -29.828 -11.166 43.340  1.00 43.06 ? 85  LEU B CD1 1 
ATOM   2895 C  CD2 . LEU B 1 80  ? -27.992 -12.312 44.584  1.00 43.34 ? 85  LEU B CD2 1 
ATOM   2896 N  N   . ILE B 1 81  ? -31.636 -15.365 43.743  1.00 42.36 ? 86  ILE B N   1 
ATOM   2897 C  CA  . ILE B 1 81  ? -31.754 -16.367 42.643  1.00 42.02 ? 86  ILE B CA  1 
ATOM   2898 C  C   . ILE B 1 81  ? -33.183 -16.932 42.469  1.00 42.17 ? 86  ILE B C   1 
ATOM   2899 O  O   . ILE B 1 81  ? -33.721 -17.571 43.384  1.00 42.25 ? 86  ILE B O   1 
ATOM   2900 C  CB  . ILE B 1 81  ? -30.763 -17.573 42.846  1.00 42.18 ? 86  ILE B CB  1 
ATOM   2901 C  CG1 . ILE B 1 81  ? -29.384 -17.127 43.397  1.00 42.06 ? 86  ILE B CG1 1 
ATOM   2902 C  CG2 . ILE B 1 81  ? -30.655 -18.444 41.565  1.00 40.90 ? 86  ILE B CG2 1 
ATOM   2903 C  CD1 . ILE B 1 81  ? -28.606 -16.148 42.537  1.00 40.41 ? 86  ILE B CD1 1 
ATOM   2904 N  N   . VAL B 1 82  ? -33.782 -16.716 41.293  1.00 42.19 ? 87  VAL B N   1 
ATOM   2905 C  CA  . VAL B 1 82  ? -35.206 -17.023 41.062  1.00 41.97 ? 87  VAL B CA  1 
ATOM   2906 C  C   . VAL B 1 82  ? -35.461 -18.379 40.332  1.00 42.22 ? 87  VAL B C   1 
ATOM   2907 O  O   . VAL B 1 82  ? -34.720 -18.768 39.409  1.00 41.62 ? 87  VAL B O   1 
ATOM   2908 C  CB  . VAL B 1 82  ? -35.946 -15.804 40.398  1.00 42.26 ? 87  VAL B CB  1 
ATOM   2909 C  CG1 . VAL B 1 82  ? -35.624 -15.696 38.916  1.00 42.76 ? 87  VAL B CG1 1 
ATOM   2910 C  CG2 . VAL B 1 82  ? -37.472 -15.852 40.633  1.00 42.48 ? 87  VAL B CG2 1 
ATOM   2911 N  N   . ASN B 1 83  ? -36.510 -19.083 40.781  1.00 42.00 ? 88  ASN B N   1 
ATOM   2912 C  CA  . ASN B 1 83  ? -36.920 -20.408 40.262  1.00 41.75 ? 88  ASN B CA  1 
ATOM   2913 C  C   . ASN B 1 83  ? -35.812 -21.436 40.150  1.00 41.17 ? 88  ASN B C   1 
ATOM   2914 O  O   . ASN B 1 83  ? -35.858 -22.259 39.230  1.00 41.72 ? 88  ASN B O   1 
ATOM   2915 C  CB  . ASN B 1 83  ? -37.561 -20.295 38.870  1.00 42.26 ? 88  ASN B CB  1 
ATOM   2916 C  CG  . ASN B 1 83  ? -38.591 -19.206 38.779  1.00 43.56 ? 88  ASN B CG  1 
ATOM   2917 O  OD1 . ASN B 1 83  ? -39.252 -18.878 39.763  1.00 46.40 ? 88  ASN B OD1 1 
ATOM   2918 N  ND2 . ASN B 1 83  ? -38.742 -18.635 37.584  1.00 43.65 ? 88  ASN B ND2 1 
ATOM   2919 N  N   . PRO B 1 84  ? -34.824 -21.419 41.068  1.00 40.66 ? 89  PRO B N   1 
ATOM   2920 C  CA  . PRO B 1 84  ? -33.636 -22.220 40.755  1.00 40.17 ? 89  PRO B CA  1 
ATOM   2921 C  C   . PRO B 1 84  ? -33.928 -23.708 40.655  1.00 40.08 ? 89  PRO B C   1 
ATOM   2922 O  O   . PRO B 1 84  ? -33.354 -24.389 39.797  1.00 40.57 ? 89  PRO B O   1 
ATOM   2923 C  CB  . PRO B 1 84  ? -32.675 -21.926 41.916  1.00 40.15 ? 89  PRO B CB  1 
ATOM   2924 C  CG  . PRO B 1 84  ? -33.545 -21.473 43.052  1.00 40.69 ? 89  PRO B CG  1 
ATOM   2925 C  CD  . PRO B 1 84  ? -34.826 -20.926 42.461  1.00 40.46 ? 89  PRO B CD  1 
ATOM   2926 N  N   . ARG B 1 85  ? -34.825 -24.208 41.503  1.00 39.22 ? 90  ARG B N   1 
ATOM   2927 C  CA  . ARG B 1 85  ? -35.195 -25.616 41.456  1.00 38.55 ? 90  ARG B CA  1 
ATOM   2928 C  C   . ARG B 1 85  ? -35.679 -26.067 40.097  1.00 36.93 ? 90  ARG B C   1 
ATOM   2929 O  O   . ARG B 1 85  ? -35.221 -27.092 39.599  1.00 36.66 ? 90  ARG B O   1 
ATOM   2930 C  CB  . ARG B 1 85  ? -36.264 -25.946 42.509  1.00 39.08 ? 90  ARG B CB  1 
ATOM   2931 C  CG  . ARG B 1 85  ? -35.680 -26.240 43.873  1.00 41.94 ? 90  ARG B CG  1 
ATOM   2932 C  CD  . ARG B 1 85  ? -34.924 -27.567 43.853  1.00 45.81 ? 90  ARG B CD  1 
ATOM   2933 N  NE  . ARG B 1 85  ? -35.467 -28.484 44.854  1.00 48.64 ? 90  ARG B NE  1 
ATOM   2934 C  CZ  . ARG B 1 85  ? -34.991 -29.695 45.134  1.00 50.01 ? 90  ARG B CZ  1 
ATOM   2935 N  NH1 . ARG B 1 85  ? -33.921 -30.181 44.514  1.00 50.63 ? 90  ARG B NH1 1 
ATOM   2936 N  NH2 . ARG B 1 85  ? -35.590 -30.424 46.063  1.00 51.25 ? 90  ARG B NH2 1 
ATOM   2937 N  N   . SER B 1 86  ? -36.620 -25.319 39.520  1.00 35.65 ? 91  SER B N   1 
ATOM   2938 C  CA  . SER B 1 86  ? -37.180 -25.649 38.220  1.00 34.97 ? 91  SER B CA  1 
ATOM   2939 C  C   . SER B 1 86  ? -36.074 -25.729 37.159  1.00 33.98 ? 91  SER B C   1 
ATOM   2940 O  O   . SER B 1 86  ? -36.051 -26.665 36.353  1.00 33.65 ? 91  SER B O   1 
ATOM   2941 C  CB  . SER B 1 86  ? -38.226 -24.620 37.801  1.00 35.48 ? 91  SER B CB  1 
ATOM   2942 O  OG  . SER B 1 86  ? -39.300 -24.578 38.730  1.00 38.79 ? 91  SER B OG  1 
ATOM   2943 N  N   . VAL B 1 87  ? -35.159 -24.762 37.211  1.00 32.63 ? 92  VAL B N   1 
ATOM   2944 C  CA  . VAL B 1 87  ? -34.029 -24.646 36.290  1.00 32.02 ? 92  VAL B CA  1 
ATOM   2945 C  C   . VAL B 1 87  ? -33.019 -25.763 36.479  1.00 32.45 ? 92  VAL B C   1 
ATOM   2946 O  O   . VAL B 1 87  ? -32.566 -26.365 35.493  1.00 32.42 ? 92  VAL B O   1 
ATOM   2947 C  CB  . VAL B 1 87  ? -33.301 -23.290 36.449  1.00 32.28 ? 92  VAL B CB  1 
ATOM   2948 C  CG1 . VAL B 1 87  ? -32.002 -23.270 35.635  1.00 30.21 ? 92  VAL B CG1 1 
ATOM   2949 C  CG2 . VAL B 1 87  ? -34.226 -22.156 36.057  1.00 29.58 ? 92  VAL B CG2 1 
ATOM   2950 N  N   . GLY B 1 88  ? -32.661 -26.039 37.734  1.00 31.93 ? 93  GLY B N   1 
ATOM   2951 C  CA  . GLY B 1 88  ? -31.720 -27.114 38.032  1.00 31.88 ? 93  GLY B CA  1 
ATOM   2952 C  C   . GLY B 1 88  ? -32.234 -28.465 37.568  1.00 31.97 ? 93  GLY B C   1 
ATOM   2953 O  O   . GLY B 1 88  ? -31.480 -29.247 36.976  1.00 31.75 ? 93  GLY B O   1 
ATOM   2954 N  N   . LEU B 1 89  ? -33.525 -28.714 37.815  1.00 31.95 ? 94  LEU B N   1 
ATOM   2955 C  CA  . LEU B 1 89  ? -34.176 -30.000 37.515  1.00 32.00 ? 94  LEU B CA  1 
ATOM   2956 C  C   . LEU B 1 89  ? -34.394 -30.198 36.025  1.00 31.65 ? 94  LEU B C   1 
ATOM   2957 O  O   . LEU B 1 89  ? -34.029 -31.242 35.485  1.00 31.67 ? 94  LEU B O   1 
ATOM   2958 C  CB  . LEU B 1 89  ? -35.531 -30.141 38.237  1.00 31.60 ? 94  LEU B CB  1 
ATOM   2959 C  CG  . LEU B 1 89  ? -36.368 -31.407 37.934  1.00 34.80 ? 94  LEU B CG  1 
ATOM   2960 C  CD1 . LEU B 1 89  ? -35.764 -32.621 38.624  1.00 35.84 ? 94  LEU B CD1 1 
ATOM   2961 C  CD2 . LEU B 1 89  ? -37.860 -31.296 38.306  1.00 34.44 ? 94  LEU B CD2 1 
ATOM   2962 N  N   . ALA B 1 90  ? -35.048 -29.223 35.389  1.00 30.83 ? 95  ALA B N   1 
ATOM   2963 C  CA  . ALA B 1 90  ? -35.229 -29.229 33.949  1.00 30.06 ? 95  ALA B CA  1 
ATOM   2964 C  C   . ALA B 1 90  ? -33.889 -29.493 33.223  1.00 29.48 ? 95  ALA B C   1 
ATOM   2965 O  O   . ALA B 1 90  ? -33.854 -30.215 32.224  1.00 29.75 ? 95  ALA B O   1 
ATOM   2966 C  CB  . ALA B 1 90  ? -35.835 -27.925 33.491  1.00 30.46 ? 95  ALA B CB  1 
ATOM   2967 N  N   . ASN B 1 91  ? -32.801 -28.916 33.723  1.00 28.47 ? 96  ASN B N   1 
ATOM   2968 C  CA  . ASN B 1 91  ? -31.496 -29.150 33.134  1.00 28.21 ? 96  ASN B CA  1 
ATOM   2969 C  C   . ASN B 1 91  ? -31.027 -30.586 33.315  1.00 28.34 ? 96  ASN B C   1 
ATOM   2970 O  O   . ASN B 1 91  ? -30.342 -31.136 32.448  1.00 27.15 ? 96  ASN B O   1 
ATOM   2971 C  CB  . ASN B 1 91  ? -30.437 -28.166 33.657  1.00 27.24 ? 96  ASN B CB  1 
ATOM   2972 C  CG  . ASN B 1 91  ? -30.374 -26.890 32.832  1.00 28.49 ? 96  ASN B CG  1 
ATOM   2973 O  OD1 . ASN B 1 91  ? -30.159 -26.938 31.605  1.00 27.96 ? 96  ASN B OD1 1 
ATOM   2974 N  ND2 . ASN B 1 91  ? -30.586 -25.742 33.486  1.00 25.49 ? 96  ASN B ND2 1 
ATOM   2975 N  N   . GLN B 1 92  ? -31.356 -31.192 34.458  1.00 28.52 ? 97  GLN B N   1 
ATOM   2976 C  CA  . GLN B 1 92  ? -31.013 -32.601 34.679  1.00 28.20 ? 97  GLN B CA  1 
ATOM   2977 C  C   . GLN B 1 92  ? -31.757 -33.467 33.672  1.00 28.11 ? 97  GLN B C   1 
ATOM   2978 O  O   . GLN B 1 92  ? -31.194 -34.381 33.089  1.00 28.71 ? 97  GLN B O   1 
ATOM   2979 C  CB  . GLN B 1 92  ? -31.365 -33.017 36.117  1.00 29.13 ? 97  GLN B CB  1 
ATOM   2980 C  CG  . GLN B 1 92  ? -30.742 -34.362 36.556  1.00 30.80 ? 97  GLN B CG  1 
ATOM   2981 C  CD  . GLN B 1 92  ? -31.211 -34.804 37.948  1.00 34.43 ? 97  GLN B CD  1 
ATOM   2982 O  OE1 . GLN B 1 92  ? -31.872 -34.048 38.656  1.00 35.88 ? 97  GLN B OE1 1 
ATOM   2983 N  NE2 . GLN B 1 92  ? -30.880 -36.035 38.335  1.00 35.22 ? 97  GLN B NE2 1 
ATOM   2984 N  N   . GLU B 1 93  ? -33.032 -33.167 33.460  1.00 28.15 ? 98  GLU B N   1 
ATOM   2985 C  CA  . GLU B 1 93  ? -33.846 -33.884 32.483  1.00 29.29 ? 98  GLU B CA  1 
ATOM   2986 C  C   . GLU B 1 93  ? -33.332 -33.679 31.038  1.00 29.19 ? 98  GLU B C   1 
ATOM   2987 O  O   . GLU B 1 93  ? -33.277 -34.624 30.239  1.00 28.93 ? 98  GLU B O   1 
ATOM   2988 C  CB  . GLU B 1 93  ? -35.313 -33.451 32.624  1.00 30.46 ? 98  GLU B CB  1 
ATOM   2989 C  CG  . GLU B 1 93  ? -35.879 -33.757 34.050  1.00 32.66 ? 98  GLU B CG  1 
ATOM   2990 C  CD  . GLU B 1 93  ? -37.385 -33.545 34.172  1.00 38.70 ? 98  GLU B CD  1 
ATOM   2991 O  OE1 . GLU B 1 93  ? -37.901 -32.487 33.732  1.00 39.40 ? 98  GLU B OE1 1 
ATOM   2992 O  OE2 . GLU B 1 93  ? -38.060 -34.442 34.739  1.00 42.45 ? 98  GLU B OE2 1 
ATOM   2993 N  N   . LEU B 1 94  ? -32.948 -32.436 30.726  1.00 28.41 ? 99  LEU B N   1 
ATOM   2994 C  CA  . LEU B 1 94  ? -32.410 -32.089 29.400  1.00 27.21 ? 99  LEU B CA  1 
ATOM   2995 C  C   . LEU B 1 94  ? -31.130 -32.846 29.118  1.00 26.37 ? 99  LEU B C   1 
ATOM   2996 O  O   . LEU B 1 94  ? -30.949 -33.373 28.017  1.00 27.29 ? 99  LEU B O   1 
ATOM   2997 C  CB  . LEU B 1 94  ? -32.115 -30.586 29.309  1.00 26.66 ? 99  LEU B CB  1 
ATOM   2998 C  CG  . LEU B 1 94  ? -31.436 -30.126 28.008  1.00 26.81 ? 99  LEU B CG  1 
ATOM   2999 C  CD1 . LEU B 1 94  ? -32.302 -30.509 26.792  1.00 24.67 ? 99  LEU B CD1 1 
ATOM   3000 C  CD2 . LEU B 1 94  ? -31.240 -28.623 28.089  1.00 25.16 ? 99  LEU B CD2 1 
ATOM   3001 N  N   . ALA B 1 95  ? -30.237 -32.847 30.099  1.00 25.90 ? 100 ALA B N   1 
ATOM   3002 C  CA  . ALA B 1 95  ? -28.964 -33.530 30.011  1.00 26.71 ? 100 ALA B CA  1 
ATOM   3003 C  C   . ALA B 1 95  ? -29.076 -35.040 29.692  1.00 27.64 ? 100 ALA B C   1 
ATOM   3004 O  O   . ALA B 1 95  ? -28.251 -35.570 28.945  1.00 27.03 ? 100 ALA B O   1 
ATOM   3005 C  CB  . ALA B 1 95  ? -28.174 -33.311 31.269  1.00 26.16 ? 100 ALA B CB  1 
ATOM   3006 N  N   . GLU B 1 96  ? -30.078 -35.726 30.253  1.00 28.51 ? 101 GLU B N   1 
ATOM   3007 C  CA  . GLU B 1 96  ? -30.325 -37.150 29.895  1.00 29.71 ? 101 GLU B CA  1 
ATOM   3008 C  C   . GLU B 1 96  ? -30.732 -37.315 28.440  1.00 28.85 ? 101 GLU B C   1 
ATOM   3009 O  O   . GLU B 1 96  ? -30.295 -38.264 27.783  1.00 28.89 ? 101 GLU B O   1 
ATOM   3010 C  CB  . GLU B 1 96  ? -31.388 -37.823 30.796  1.00 29.90 ? 101 GLU B CB  1 
ATOM   3011 C  CG  . GLU B 1 96  ? -31.165 -37.599 32.289  1.00 34.11 ? 101 GLU B CG  1 
ATOM   3012 C  CD  . GLU B 1 96  ? -30.952 -38.877 33.111  1.00 40.44 ? 101 GLU B CD  1 
ATOM   3013 O  OE1 . GLU B 1 96  ? -31.575 -38.968 34.193  1.00 40.88 ? 101 GLU B OE1 1 
ATOM   3014 O  OE2 . GLU B 1 96  ? -30.146 -39.762 32.710  1.00 42.98 ? 101 GLU B OE2 1 
ATOM   3015 N  N   . VAL B 1 97  ? -31.587 -36.423 27.943  1.00 28.34 ? 102 VAL B N   1 
ATOM   3016 C  CA  . VAL B 1 97  ? -32.002 -36.486 26.537  1.00 28.27 ? 102 VAL B CA  1 
ATOM   3017 C  C   . VAL B 1 97  ? -30.826 -36.250 25.567  1.00 28.07 ? 102 VAL B C   1 
ATOM   3018 O  O   . VAL B 1 97  ? -30.670 -36.970 24.563  1.00 27.38 ? 102 VAL B O   1 
ATOM   3019 C  CB  . VAL B 1 97  ? -33.173 -35.545 26.223  1.00 27.73 ? 102 VAL B CB  1 
ATOM   3020 C  CG1 . VAL B 1 97  ? -33.515 -35.606 24.741  1.00 28.83 ? 102 VAL B CG1 1 
ATOM   3021 C  CG2 . VAL B 1 97  ? -34.411 -35.940 27.048  1.00 28.62 ? 102 VAL B CG2 1 
ATOM   3022 N  N   . VAL B 1 98  ? -30.008 -35.244 25.889  1.00 27.78 ? 103 VAL B N   1 
ATOM   3023 C  CA  . VAL B 1 98  ? -28.805 -34.929 25.129  1.00 26.82 ? 103 VAL B CA  1 
ATOM   3024 C  C   . VAL B 1 98  ? -27.833 -36.098 25.213  1.00 28.25 ? 103 VAL B C   1 
ATOM   3025 O  O   . VAL B 1 98  ? -27.293 -36.522 24.182  1.00 27.54 ? 103 VAL B O   1 
ATOM   3026 C  CB  . VAL B 1 98  ? -28.154 -33.606 25.611  1.00 26.93 ? 103 VAL B CB  1 
ATOM   3027 C  CG1 . VAL B 1 98  ? -26.744 -33.441 25.020  1.00 24.75 ? 103 VAL B CG1 1 
ATOM   3028 C  CG2 . VAL B 1 98  ? -29.066 -32.420 25.237  1.00 24.87 ? 103 VAL B CG2 1 
ATOM   3029 N  N   . SER B 1 99  ? -27.629 -36.640 26.421  1.00 28.75 ? 104 SER B N   1 
ATOM   3030 C  CA  . SER B 1 99  ? -26.746 -37.801 26.573  1.00 29.31 ? 104 SER B CA  1 
ATOM   3031 C  C   . SER B 1 99  ? -27.173 -38.956 25.647  1.00 29.67 ? 104 SER B C   1 
ATOM   3032 O  O   . SER B 1 99  ? -26.351 -39.518 24.907  1.00 29.25 ? 104 SER B O   1 
ATOM   3033 C  CB  . SER B 1 99  ? -26.648 -38.259 28.038  1.00 29.23 ? 104 SER B CB  1 
ATOM   3034 O  OG  . SER B 1 99  ? -25.444 -38.995 28.214  1.00 30.74 ? 104 SER B OG  1 
ATOM   3035 N  N   . ARG B 1 100 ? -28.463 -39.282 25.660  1.00 30.38 ? 105 ARG B N   1 
ATOM   3036 C  CA  . ARG B 1 100 ? -28.955 -40.385 24.834  1.00 31.70 ? 105 ARG B CA  1 
ATOM   3037 C  C   . ARG B 1 100 ? -28.952 -40.058 23.327  1.00 31.40 ? 105 ARG B C   1 
ATOM   3038 O  O   . ARG B 1 100 ? -28.714 -40.948 22.508  1.00 32.14 ? 105 ARG B O   1 
ATOM   3039 C  CB  . ARG B 1 100 ? -30.305 -40.932 25.345  1.00 32.86 ? 105 ARG B CB  1 
ATOM   3040 C  CG  . ARG B 1 100 ? -31.569 -40.334 24.732  1.00 35.59 ? 105 ARG B CG  1 
ATOM   3041 C  CD  . ARG B 1 100 ? -32.790 -41.178 25.138  1.00 41.47 ? 105 ARG B CD  1 
ATOM   3042 N  NE  . ARG B 1 100 ? -34.046 -40.536 24.738  1.00 44.94 ? 105 ARG B NE  1 
ATOM   3043 C  CZ  . ARG B 1 100 ? -34.834 -39.844 25.555  1.00 46.54 ? 105 ARG B CZ  1 
ATOM   3044 N  NH1 . ARG B 1 100 ? -34.513 -39.712 26.845  1.00 47.69 ? 105 ARG B NH1 1 
ATOM   3045 N  NH2 . ARG B 1 100 ? -35.950 -39.293 25.086  1.00 46.66 ? 105 ARG B NH2 1 
ATOM   3046 N  N   . ALA B 1 101 ? -29.175 -38.795 22.957  1.00 31.05 ? 106 ALA B N   1 
ATOM   3047 C  CA  . ALA B 1 101 ? -29.082 -38.393 21.529  1.00 30.29 ? 106 ALA B CA  1 
ATOM   3048 C  C   . ALA B 1 101 ? -27.661 -38.555 21.020  1.00 29.90 ? 106 ALA B C   1 
ATOM   3049 O  O   . ALA B 1 101 ? -27.440 -39.130 19.936  1.00 29.58 ? 106 ALA B O   1 
ATOM   3050 C  CB  . ALA B 1 101 ? -29.564 -36.979 21.302  1.00 29.35 ? 106 ALA B CB  1 
ATOM   3051 N  N   . VAL B 1 102 ? -26.707 -38.081 21.822  1.00 29.24 ? 107 VAL B N   1 
ATOM   3052 C  CA  . VAL B 1 102 ? -25.285 -38.170 21.479  1.00 29.39 ? 107 VAL B CA  1 
ATOM   3053 C  C   . VAL B 1 102 ? -24.963 -39.617 21.316  1.00 29.63 ? 107 VAL B C   1 
ATOM   3054 O  O   . VAL B 1 102 ? -24.414 -40.016 20.308  1.00 29.62 ? 107 VAL B O   1 
ATOM   3055 C  CB  . VAL B 1 102 ? -24.355 -37.482 22.520  1.00 28.16 ? 107 VAL B CB  1 
ATOM   3056 C  CG1 . VAL B 1 102 ? -22.899 -37.855 22.272  1.00 28.52 ? 107 VAL B CG1 1 
ATOM   3057 C  CG2 . VAL B 1 102 ? -24.501 -35.993 22.423  1.00 28.64 ? 107 VAL B CG2 1 
ATOM   3058 N  N   . SER B 1 103 ? -25.352 -40.396 22.319  1.00 31.15 ? 108 SER B N   1 
ATOM   3059 C  CA  . SER B 1 103 ? -25.250 -41.853 22.324  1.00 32.14 ? 108 SER B CA  1 
ATOM   3060 C  C   . SER B 1 103 ? -25.828 -42.578 21.084  1.00 32.01 ? 108 SER B C   1 
ATOM   3061 O  O   . SER B 1 103 ? -25.259 -43.554 20.618  1.00 32.39 ? 108 SER B O   1 
ATOM   3062 C  CB  . SER B 1 103 ? -25.936 -42.362 23.596  1.00 31.93 ? 108 SER B CB  1 
ATOM   3063 O  OG  . SER B 1 103 ? -25.584 -43.700 23.845  1.00 35.52 ? 108 SER B OG  1 
ATOM   3064 N  N   . ASP B 1 104 ? -26.972 -42.117 20.576  1.00 32.50 ? 109 ASP B N   1 
ATOM   3065 C  CA  . ASP B 1 104 ? -27.632 -42.736 19.416  1.00 32.36 ? 109 ASP B CA  1 
ATOM   3066 C  C   . ASP B 1 104 ? -26.926 -42.338 18.113  1.00 32.19 ? 109 ASP B C   1 
ATOM   3067 O  O   . ASP B 1 104 ? -27.445 -42.601 17.014  1.00 32.14 ? 109 ASP B O   1 
ATOM   3068 C  CB  . ASP B 1 104 ? -29.126 -42.312 19.354  1.00 33.27 ? 109 ASP B CB  1 
ATOM   3069 C  CG  . ASP B 1 104 ? -29.974 -42.891 20.500  1.00 34.68 ? 109 ASP B CG  1 
ATOM   3070 O  OD1 . ASP B 1 104 ? -29.585 -43.905 21.102  1.00 36.19 ? 109 ASP B OD1 1 
ATOM   3071 O  OD2 . ASP B 1 104 ? -31.055 -42.329 20.804  1.00 39.20 ? 109 ASP B OD2 1 
ATOM   3072 N  N   . GLY B 1 105 ? -25.768 -41.685 18.247  1.00 31.26 ? 110 GLY B N   1 
ATOM   3073 C  CA  . GLY B 1 105 ? -24.989 -41.171 17.108  1.00 30.99 ? 110 GLY B CA  1 
ATOM   3074 C  C   . GLY B 1 105 ? -25.460 -39.862 16.472  1.00 29.88 ? 110 GLY B C   1 
ATOM   3075 O  O   . GLY B 1 105 ? -25.124 -39.578 15.319  1.00 29.59 ? 110 GLY B O   1 
ATOM   3076 N  N   . TYR B 1 106 ? -26.245 -39.057 17.192  1.00 28.75 ? 111 TYR B N   1 
ATOM   3077 C  CA  . TYR B 1 106 ? -26.691 -37.776 16.628  1.00 27.74 ? 111 TYR B CA  1 
ATOM   3078 C  C   . TYR B 1 106 ? -25.902 -36.554 17.110  1.00 27.09 ? 111 TYR B C   1 
ATOM   3079 O  O   . TYR B 1 106 ? -25.530 -36.477 18.274  1.00 26.30 ? 111 TYR B O   1 
ATOM   3080 C  CB  . TYR B 1 106 ? -28.165 -37.528 16.920  1.00 27.57 ? 111 TYR B CB  1 
ATOM   3081 C  CG  . TYR B 1 106 ? -29.139 -38.316 16.077  1.00 28.69 ? 111 TYR B CG  1 
ATOM   3082 C  CD1 . TYR B 1 106 ? -29.673 -39.514 16.548  1.00 29.58 ? 111 TYR B CD1 1 
ATOM   3083 C  CD2 . TYR B 1 106 ? -29.550 -37.850 14.822  1.00 30.58 ? 111 TYR B CD2 1 
ATOM   3084 C  CE1 . TYR B 1 106 ? -30.579 -40.244 15.794  1.00 30.11 ? 111 TYR B CE1 1 
ATOM   3085 C  CE2 . TYR B 1 106 ? -30.458 -38.576 14.049  1.00 30.90 ? 111 TYR B CE2 1 
ATOM   3086 C  CZ  . TYR B 1 106 ? -30.971 -39.777 14.552  1.00 30.92 ? 111 TYR B CZ  1 
ATOM   3087 O  OH  . TYR B 1 106 ? -31.872 -40.516 13.811  1.00 30.69 ? 111 TYR B OH  1 
ATOM   3088 N  N   . SER B 1 107 ? -25.664 -35.606 16.198  1.00 26.11 ? 112 SER B N   1 
ATOM   3089 C  CA  . SER B 1 107 ? -25.212 -34.260 16.590  1.00 26.23 ? 112 SER B CA  1 
ATOM   3090 C  C   . SER B 1 107 ? -26.397 -33.598 17.184  1.00 25.50 ? 112 SER B C   1 
ATOM   3091 O  O   . SER B 1 107 ? -27.470 -33.573 16.561  1.00 25.13 ? 112 SER B O   1 
ATOM   3092 C  CB  . SER B 1 107 ? -24.747 -33.430 15.391  1.00 26.02 ? 112 SER B CB  1 
ATOM   3093 O  OG  . SER B 1 107 ? -23.535 -33.949 14.906  1.00 28.02 ? 112 SER B OG  1 
ATOM   3094 N  N   . CYS B 1 108 ? -26.218 -33.048 18.379  1.00 25.25 ? 113 CYS B N   1 
ATOM   3095 C  CA  . CYS B 1 108 ? -27.360 -32.588 19.138  1.00 25.76 ? 113 CYS B CA  1 
ATOM   3096 C  C   . CYS B 1 108 ? -27.617 -31.079 19.062  1.00 24.34 ? 113 CYS B C   1 
ATOM   3097 O  O   . CYS B 1 108 ? -26.864 -30.312 19.615  1.00 24.12 ? 113 CYS B O   1 
ATOM   3098 C  CB  . CYS B 1 108 ? -27.239 -33.062 20.586  1.00 26.34 ? 113 CYS B CB  1 
ATOM   3099 S  SG  . CYS B 1 108 ? -28.788 -32.929 21.403  1.00 35.57 ? 113 CYS B SG  1 
ATOM   3100 N  N   . VAL B 1 109 ? -28.699 -30.694 18.379  1.00 22.78 ? 114 VAL B N   1 
ATOM   3101 C  CA  . VAL B 1 109 ? -29.163 -29.321 18.285  1.00 22.23 ? 114 VAL B CA  1 
ATOM   3102 C  C   . VAL B 1 109 ? -30.280 -29.097 19.311  1.00 22.31 ? 114 VAL B C   1 
ATOM   3103 O  O   . VAL B 1 109 ? -31.354 -29.705 19.212  1.00 21.89 ? 114 VAL B O   1 
ATOM   3104 C  CB  . VAL B 1 109 ? -29.709 -29.035 16.851  1.00 22.30 ? 114 VAL B CB  1 
ATOM   3105 C  CG1 . VAL B 1 109 ? -30.377 -27.677 16.770  1.00 21.66 ? 114 VAL B CG1 1 
ATOM   3106 C  CG2 . VAL B 1 109 ? -28.555 -29.154 15.815  1.00 22.33 ? 114 VAL B CG2 1 
ATOM   3107 N  N   . THR B 1 110 ? -30.018 -28.228 20.284  1.00 21.82 ? 115 THR B N   1 
ATOM   3108 C  CA  . THR B 1 110 ? -31.018 -27.828 21.259  1.00 20.90 ? 115 THR B CA  1 
ATOM   3109 C  C   . THR B 1 110 ? -31.487 -26.402 21.009  1.00 21.08 ? 115 THR B C   1 
ATOM   3110 O  O   . THR B 1 110 ? -30.686 -25.458 20.998  1.00 21.51 ? 115 THR B O   1 
ATOM   3111 C  CB  . THR B 1 110 ? -30.446 -27.960 22.686  1.00 21.44 ? 115 THR B CB  1 
ATOM   3112 O  OG1 . THR B 1 110 ? -29.840 -29.258 22.853  1.00 21.38 ? 115 THR B OG1 1 
ATOM   3113 C  CG2 . THR B 1 110 ? -31.531 -27.744 23.734  1.00 19.45 ? 115 THR B CG2 1 
ATOM   3114 N  N   . LEU B 1 111 ? -32.781 -26.264 20.772  1.00 20.99 ? 116 LEU B N   1 
ATOM   3115 C  CA  . LEU B 1 111 ? -33.427 -24.984 20.560  1.00 21.78 ? 116 LEU B CA  1 
ATOM   3116 C  C   . LEU B 1 111 ? -33.909 -24.456 21.906  1.00 22.25 ? 116 LEU B C   1 
ATOM   3117 O  O   . LEU B 1 111 ? -34.455 -25.223 22.726  1.00 22.40 ? 116 LEU B O   1 
ATOM   3118 C  CB  . LEU B 1 111 ? -34.618 -25.135 19.596  1.00 21.31 ? 116 LEU B CB  1 
ATOM   3119 C  CG  . LEU B 1 111 ? -34.292 -25.900 18.311  1.00 22.19 ? 116 LEU B CG  1 
ATOM   3120 C  CD1 . LEU B 1 111 ? -35.489 -25.941 17.476  1.00 22.28 ? 116 LEU B CD1 1 
ATOM   3121 C  CD2 . LEU B 1 111 ? -33.102 -25.245 17.564  1.00 22.34 ? 116 LEU B CD2 1 
ATOM   3122 N  N   . GLY B 1 112 ? -33.689 -23.158 22.123  1.00 22.06 ? 117 GLY B N   1 
ATOM   3123 C  CA  . GLY B 1 112 ? -34.025 -22.490 23.368  1.00 22.28 ? 117 GLY B CA  1 
ATOM   3124 C  C   . GLY B 1 112 ? -35.155 -21.528 23.129  1.00 22.33 ? 117 GLY B C   1 
ATOM   3125 O  O   . GLY B 1 112 ? -35.496 -21.256 21.984  1.00 22.36 ? 117 GLY B O   1 
ATOM   3126 N  N   . GLY B 1 113 ? -35.738 -20.984 24.200  1.00 22.82 ? 118 GLY B N   1 
ATOM   3127 C  CA  . GLY B 1 113 ? -35.255 -21.202 25.572  1.00 22.94 ? 118 GLY B CA  1 
ATOM   3128 C  C   . GLY B 1 113 ? -34.104 -20.286 25.975  1.00 23.09 ? 118 GLY B C   1 
ATOM   3129 O  O   . GLY B 1 113 ? -33.294 -19.867 25.127  1.00 23.27 ? 118 GLY B O   1 
ATOM   3130 N  N   . ASP B 1 114 ? -34.003 -19.987 27.271  1.00 21.75 ? 119 ASP B N   1 
ATOM   3131 C  CA  . ASP B 1 114 ? -32.954 -19.100 27.743  1.00 21.20 ? 119 ASP B CA  1 
ATOM   3132 C  C   . ASP B 1 114 ? -31.672 -19.855 27.926  1.00 20.44 ? 119 ASP B C   1 
ATOM   3133 O  O   . ASP B 1 114 ? -31.669 -21.091 27.932  1.00 20.80 ? 119 ASP B O   1 
ATOM   3134 C  CB  . ASP B 1 114 ? -33.359 -18.365 29.039  1.00 21.11 ? 119 ASP B CB  1 
ATOM   3135 C  CG  . ASP B 1 114 ? -33.504 -19.285 30.210  1.00 22.90 ? 119 ASP B CG  1 
ATOM   3136 O  OD1 . ASP B 1 114 ? -32.483 -19.783 30.714  1.00 25.01 ? 119 ASP B OD1 1 
ATOM   3137 O  OD2 . ASP B 1 114 ? -34.669 -19.495 30.638  1.00 29.21 ? 119 ASP B OD2 1 
ATOM   3138 N  N   . HIS B 1 115 ? -30.581 -19.132 28.141  1.00 20.01 ? 120 HIS B N   1 
ATOM   3139 C  CA  . HIS B 1 115 ? -29.253 -19.746 28.053  1.00 21.05 ? 120 HIS B CA  1 
ATOM   3140 C  C   . HIS B 1 115 ? -28.879 -20.630 29.247  1.00 21.01 ? 120 HIS B C   1 
ATOM   3141 O  O   . HIS B 1 115 ? -27.799 -21.286 29.259  1.00 20.48 ? 120 HIS B O   1 
ATOM   3142 C  CB  . HIS B 1 115 ? -28.164 -18.675 27.818  1.00 20.22 ? 120 HIS B CB  1 
ATOM   3143 C  CG  . HIS B 1 115 ? -27.046 -19.141 26.936  1.00 20.77 ? 120 HIS B CG  1 
ATOM   3144 N  ND1 . HIS B 1 115 ? -26.259 -18.272 26.210  1.00 17.81 ? 120 HIS B ND1 1 
ATOM   3145 C  CD2 . HIS B 1 115 ? -26.616 -20.391 26.625  1.00 18.45 ? 120 HIS B CD2 1 
ATOM   3146 C  CE1 . HIS B 1 115 ? -25.385 -18.960 25.497  1.00 20.28 ? 120 HIS B CE1 1 
ATOM   3147 N  NE2 . HIS B 1 115 ? -25.570 -20.250 25.740  1.00 21.66 ? 120 HIS B NE2 1 
ATOM   3148 N  N   . SER B 1 116 ? -29.732 -20.640 30.280  1.00 21.70 ? 121 SER B N   1 
ATOM   3149 C  CA  . SER B 1 116 ? -29.470 -21.522 31.424  1.00 21.17 ? 121 SER B CA  1 
ATOM   3150 C  C   . SER B 1 116 ? -29.544 -22.965 30.947  1.00 20.92 ? 121 SER B C   1 
ATOM   3151 O  O   . SER B 1 116 ? -28.938 -23.831 31.554  1.00 20.81 ? 121 SER B O   1 
ATOM   3152 C  CB  . SER B 1 116 ? -30.449 -21.326 32.591  1.00 20.91 ? 121 SER B CB  1 
ATOM   3153 O  OG  . SER B 1 116 ? -31.740 -21.789 32.253  1.00 21.77 ? 121 SER B OG  1 
ATOM   3154 N  N   . LEU B 1 117 ? -30.258 -23.205 29.849  1.00 20.31 ? 122 LEU B N   1 
ATOM   3155 C  CA  . LEU B 1 117 ? -30.287 -24.550 29.248  1.00 21.46 ? 122 LEU B CA  1 
ATOM   3156 C  C   . LEU B 1 117 ? -28.917 -25.141 28.879  1.00 21.13 ? 122 LEU B C   1 
ATOM   3157 O  O   . LEU B 1 117 ? -28.806 -26.370 28.697  1.00 21.80 ? 122 LEU B O   1 
ATOM   3158 C  CB  . LEU B 1 117 ? -31.257 -24.621 28.079  1.00 21.79 ? 122 LEU B CB  1 
ATOM   3159 C  CG  . LEU B 1 117 ? -30.967 -23.941 26.731  1.00 23.40 ? 122 LEU B CG  1 
ATOM   3160 C  CD1 . LEU B 1 117 ? -29.963 -24.733 25.911  1.00 24.66 ? 122 LEU B CD1 1 
ATOM   3161 C  CD2 . LEU B 1 117 ? -32.277 -23.882 25.992  1.00 25.74 ? 122 LEU B CD2 1 
ATOM   3162 N  N   . ALA B 1 118 ? -27.881 -24.297 28.781  1.00 20.66 ? 123 ALA B N   1 
ATOM   3163 C  CA  . ALA B 1 118 ? -26.525 -24.800 28.484  1.00 21.21 ? 123 ALA B CA  1 
ATOM   3164 C  C   . ALA B 1 118 ? -25.968 -25.630 29.605  1.00 21.57 ? 123 ALA B C   1 
ATOM   3165 O  O   . ALA B 1 118 ? -25.002 -26.408 29.421  1.00 21.71 ? 123 ALA B O   1 
ATOM   3166 C  CB  . ALA B 1 118 ? -25.554 -23.664 28.193  1.00 21.56 ? 123 ALA B CB  1 
ATOM   3167 N  N   . ILE B 1 119 ? -26.519 -25.434 30.797  1.00 21.48 ? 124 ILE B N   1 
ATOM   3168 C  CA  . ILE B 1 119 ? -26.071 -26.247 31.902  1.00 21.04 ? 124 ILE B CA  1 
ATOM   3169 C  C   . ILE B 1 119 ? -26.370 -27.692 31.536  1.00 19.86 ? 124 ILE B C   1 
ATOM   3170 O  O   . ILE B 1 119 ? -25.502 -28.518 31.644  1.00 20.05 ? 124 ILE B O   1 
ATOM   3171 C  CB  . ILE B 1 119 ? -26.722 -25.841 33.243  1.00 21.30 ? 124 ILE B CB  1 
ATOM   3172 C  CG1 . ILE B 1 119 ? -26.231 -24.453 33.685  1.00 21.06 ? 124 ILE B CG1 1 
ATOM   3173 C  CG2 . ILE B 1 119 ? -26.415 -26.860 34.367  1.00 20.73 ? 124 ILE B CG2 1 
ATOM   3174 C  CD1 . ILE B 1 119 ? -27.110 -23.865 34.795  1.00 23.72 ? 124 ILE B CD1 1 
ATOM   3175 N  N   . GLY B 1 120 ? -27.600 -27.960 31.112  1.00 20.38 ? 125 GLY B N   1 
ATOM   3176 C  CA  . GLY B 1 120 ? -28.049 -29.309 30.750  1.00 20.68 ? 125 GLY B CA  1 
ATOM   3177 C  C   . GLY B 1 120 ? -27.413 -29.865 29.483  1.00 20.46 ? 125 GLY B C   1 
ATOM   3178 O  O   . GLY B 1 120 ? -26.966 -31.045 29.455  1.00 20.51 ? 125 GLY B O   1 
ATOM   3179 N  N   . THR B 1 121 ? -27.320 -29.034 28.442  1.00 20.20 ? 126 THR B N   1 
ATOM   3180 C  CA  . THR B 1 121 ? -26.778 -29.523 27.148  1.00 19.93 ? 126 THR B CA  1 
ATOM   3181 C  C   . THR B 1 121 ? -25.293 -29.853 27.268  1.00 19.84 ? 126 THR B C   1 
ATOM   3182 O  O   . THR B 1 121 ? -24.875 -30.910 26.808  1.00 20.92 ? 126 THR B O   1 
ATOM   3183 C  CB  . THR B 1 121 ? -27.000 -28.563 25.944  1.00 18.99 ? 126 THR B CB  1 
ATOM   3184 O  OG1 . THR B 1 121 ? -26.238 -27.365 26.146  1.00 21.35 ? 126 THR B OG1 1 
ATOM   3185 C  CG2 . THR B 1 121 ? -28.455 -28.194 25.789  1.00 19.38 ? 126 THR B CG2 1 
ATOM   3186 N  N   . ILE B 1 122 ? -24.498 -28.966 27.867  1.00 19.47 ? 127 ILE B N   1 
ATOM   3187 C  CA  . ILE B 1 122 ? -23.054 -29.234 28.037  1.00 19.89 ? 127 ILE B CA  1 
ATOM   3188 C  C   . ILE B 1 122 ? -22.791 -30.432 28.961  1.00 20.98 ? 127 ILE B C   1 
ATOM   3189 O  O   . ILE B 1 122 ? -21.949 -31.326 28.639  1.00 21.05 ? 127 ILE B O   1 
ATOM   3190 C  CB  . ILE B 1 122 ? -22.271 -27.965 28.477  1.00 19.35 ? 127 ILE B CB  1 
ATOM   3191 C  CG1 . ILE B 1 122 ? -22.385 -26.874 27.374  1.00 19.75 ? 127 ILE B CG1 1 
ATOM   3192 C  CG2 . ILE B 1 122 ? -20.792 -28.284 28.802  1.00 19.88 ? 127 ILE B CG2 1 
ATOM   3193 C  CD1 . ILE B 1 122 ? -21.543 -25.560 27.610  1.00 20.05 ? 127 ILE B CD1 1 
ATOM   3194 N  N   . SER B 1 123 ? -23.488 -30.445 30.110  1.00 21.74 ? 128 SER B N   1 
ATOM   3195 C  CA  . SER B 1 123 ? -23.454 -31.590 31.037  1.00 23.30 ? 128 SER B CA  1 
ATOM   3196 C  C   . SER B 1 123 ? -23.748 -32.909 30.359  1.00 22.37 ? 128 SER B C   1 
ATOM   3197 O  O   . SER B 1 123 ? -22.982 -33.821 30.486  1.00 24.81 ? 128 SER B O   1 
ATOM   3198 C  CB  . SER B 1 123 ? -24.433 -31.377 32.218  1.00 22.74 ? 128 SER B CB  1 
ATOM   3199 O  OG  . SER B 1 123 ? -23.912 -30.364 33.057  1.00 25.32 ? 128 SER B OG  1 
ATOM   3200 N  N   . GLY B 1 124 ? -24.863 -33.002 29.632  1.00 23.65 ? 129 GLY B N   1 
ATOM   3201 C  CA  . GLY B 1 124 ? -25.247 -34.219 28.935  1.00 22.84 ? 129 GLY B CA  1 
ATOM   3202 C  C   . GLY B 1 124 ? -24.293 -34.642 27.836  1.00 23.81 ? 129 GLY B C   1 
ATOM   3203 O  O   . GLY B 1 124 ? -24.100 -35.828 27.590  1.00 23.33 ? 129 GLY B O   1 
ATOM   3204 N  N   . HIS B 1 125 ? -23.688 -33.650 27.184  1.00 22.99 ? 130 HIS B N   1 
ATOM   3205 C  CA  . HIS B 1 125 ? -22.751 -33.869 26.107  1.00 23.03 ? 130 HIS B CA  1 
ATOM   3206 C  C   . HIS B 1 125 ? -21.399 -34.336 26.667  1.00 22.90 ? 130 HIS B C   1 
ATOM   3207 O  O   . HIS B 1 125 ? -20.775 -35.254 26.110  1.00 23.60 ? 130 HIS B O   1 
ATOM   3208 C  CB  . HIS B 1 125 ? -22.681 -32.563 25.296  1.00 23.11 ? 130 HIS B CB  1 
ATOM   3209 C  CG  . HIS B 1 125 ? -21.825 -32.631 24.070  1.00 23.50 ? 130 HIS B CG  1 
ATOM   3210 N  ND1 . HIS B 1 125 ? -21.470 -31.502 23.364  1.00 24.05 ? 130 HIS B ND1 1 
ATOM   3211 C  CD2 . HIS B 1 125 ? -21.233 -33.673 23.441  1.00 21.58 ? 130 HIS B CD2 1 
ATOM   3212 C  CE1 . HIS B 1 125 ? -20.698 -31.848 22.345  1.00 26.35 ? 130 HIS B CE1 1 
ATOM   3213 N  NE2 . HIS B 1 125 ? -20.549 -33.161 22.364  1.00 24.49 ? 130 HIS B NE2 1 
ATOM   3214 N  N   . ALA B 1 126 ? -20.987 -33.774 27.802  1.00 22.99 ? 131 ALA B N   1 
ATOM   3215 C  CA  . ALA B 1 126 ? -19.711 -34.128 28.433  1.00 24.19 ? 131 ALA B CA  1 
ATOM   3216 C  C   . ALA B 1 126 ? -19.657 -35.547 29.029  1.00 25.02 ? 131 ALA B C   1 
ATOM   3217 O  O   . ALA B 1 126 ? -18.560 -36.036 29.290  1.00 25.89 ? 131 ALA B O   1 
ATOM   3218 C  CB  . ALA B 1 126 ? -19.295 -33.091 29.491  1.00 23.33 ? 131 ALA B CB  1 
ATOM   3219 N  N   . ARG B 1 127 ? -20.825 -36.172 29.222  1.00 26.22 ? 132 ARG B N   1 
ATOM   3220 C  CA  . ARG B 1 127 ? -20.962 -37.599 29.624  1.00 27.69 ? 132 ARG B CA  1 
ATOM   3221 C  C   . ARG B 1 127 ? -20.312 -38.579 28.631  1.00 28.50 ? 132 ARG B C   1 
ATOM   3222 O  O   . ARG B 1 127 ? -19.522 -39.450 29.020  1.00 28.56 ? 132 ARG B O   1 
ATOM   3223 C  CB  . ARG B 1 127 ? -22.440 -37.967 29.732  1.00 28.44 ? 132 ARG B CB  1 
ATOM   3224 C  CG  . ARG B 1 127 ? -22.889 -38.283 31.124  1.00 31.32 ? 132 ARG B CG  1 
ATOM   3225 C  CD  . ARG B 1 127 ? -23.549 -37.129 31.777  1.00 34.29 ? 132 ARG B CD  1 
ATOM   3226 N  NE  . ARG B 1 127 ? -24.995 -37.251 31.676  1.00 36.84 ? 132 ARG B NE  1 
ATOM   3227 C  CZ  . ARG B 1 127 ? -25.840 -36.695 32.537  1.00 36.72 ? 132 ARG B CZ  1 
ATOM   3228 N  NH1 . ARG B 1 127 ? -27.146 -36.842 32.364  1.00 37.27 ? 132 ARG B NH1 1 
ATOM   3229 N  NH2 . ARG B 1 127 ? -25.377 -35.975 33.556  1.00 37.06 ? 132 ARG B NH2 1 
ATOM   3230 N  N   . HIS B 1 128 ? -20.654 -38.426 27.350  1.00 28.85 ? 133 HIS B N   1 
ATOM   3231 C  CA  . HIS B 1 128 ? -20.056 -39.238 26.284  1.00 28.75 ? 133 HIS B CA  1 
ATOM   3232 C  C   . HIS B 1 128 ? -18.840 -38.586 25.612  1.00 29.00 ? 133 HIS B C   1 
ATOM   3233 O  O   . HIS B 1 128 ? -17.986 -39.302 25.082  1.00 28.35 ? 133 HIS B O   1 
ATOM   3234 C  CB  . HIS B 1 128 ? -21.110 -39.587 25.247  1.00 29.46 ? 133 HIS B CB  1 
ATOM   3235 C  CG  . HIS B 1 128 ? -22.249 -40.389 25.803  1.00 31.55 ? 133 HIS B CG  1 
ATOM   3236 N  ND1 . HIS B 1 128 ? -22.059 -41.595 26.448  1.00 34.23 ? 133 HIS B ND1 1 
ATOM   3237 C  CD2 . HIS B 1 128 ? -23.584 -40.154 25.827  1.00 32.11 ? 133 HIS B CD2 1 
ATOM   3238 C  CE1 . HIS B 1 128 ? -23.230 -42.073 26.836  1.00 33.96 ? 133 HIS B CE1 1 
ATOM   3239 N  NE2 . HIS B 1 128 ? -24.172 -41.223 26.463  1.00 34.20 ? 133 HIS B NE2 1 
ATOM   3240 N  N   . CYS B 1 129 ? -18.739 -37.243 25.646  1.00 28.50 ? 134 CYS B N   1 
ATOM   3241 C  CA  . CYS B 1 129 ? -17.508 -36.550 25.188  1.00 28.79 ? 134 CYS B CA  1 
ATOM   3242 C  C   . CYS B 1 129 ? -16.828 -35.692 26.262  1.00 28.17 ? 134 CYS B C   1 
ATOM   3243 O  O   . CYS B 1 129 ? -16.962 -34.457 26.250  1.00 28.34 ? 134 CYS B O   1 
ATOM   3244 C  CB  . CYS B 1 129 ? -17.744 -35.711 23.921  1.00 27.54 ? 134 CYS B CB  1 
ATOM   3245 S  SG  . CYS B 1 129 ? -18.802 -36.488 22.729  1.00 31.06 ? 134 CYS B SG  1 
ATOM   3246 N  N   . PRO B 1 130 ? -16.092 -36.342 27.191  1.00 28.00 ? 135 PRO B N   1 
ATOM   3247 C  CA  . PRO B 1 130 ? -15.351 -35.694 28.269  1.00 27.37 ? 135 PRO B CA  1 
ATOM   3248 C  C   . PRO B 1 130 ? -14.344 -34.701 27.768  1.00 26.88 ? 135 PRO B C   1 
ATOM   3249 O  O   . PRO B 1 130 ? -13.985 -33.782 28.506  1.00 27.00 ? 135 PRO B O   1 
ATOM   3250 C  CB  . PRO B 1 130 ? -14.600 -36.863 28.945  1.00 27.92 ? 135 PRO B CB  1 
ATOM   3251 C  CG  . PRO B 1 130 ? -14.690 -38.008 27.982  1.00 26.91 ? 135 PRO B CG  1 
ATOM   3252 C  CD  . PRO B 1 130 ? -16.039 -37.807 27.343  1.00 28.28 ? 135 PRO B CD  1 
ATOM   3253 N  N   . ASP B 1 131 ? -13.845 -34.889 26.547  1.00 26.23 ? 136 ASP B N   1 
ATOM   3254 C  CA  . ASP B 1 131 ? -12.785 -34.016 26.027  1.00 24.65 ? 136 ASP B CA  1 
ATOM   3255 C  C   . ASP B 1 131 ? -13.358 -32.823 25.239  1.00 23.90 ? 136 ASP B C   1 
ATOM   3256 O  O   . ASP B 1 131 ? -12.611 -32.121 24.545  1.00 24.02 ? 136 ASP B O   1 
ATOM   3257 C  CB  . ASP B 1 131 ? -11.790 -34.791 25.141  1.00 25.23 ? 136 ASP B CB  1 
ATOM   3258 C  CG  . ASP B 1 131 ? -10.433 -34.096 25.028  1.00 24.02 ? 136 ASP B CG  1 
ATOM   3259 O  OD1 . ASP B 1 131 ? -9.675  -34.334 24.053  1.00 24.90 ? 136 ASP B OD1 1 
ATOM   3260 O  OD2 . ASP B 1 131 ? -10.128 -33.285 25.906  1.00 26.38 ? 136 ASP B OD2 1 
ATOM   3261 N  N   . LEU B 1 132 ? -14.668 -32.599 25.327  1.00 23.27 ? 137 LEU B N   1 
ATOM   3262 C  CA  . LEU B 1 132 ? -15.278 -31.512 24.555  1.00 22.00 ? 137 LEU B CA  1 
ATOM   3263 C  C   . LEU B 1 132 ? -14.618 -30.149 24.803  1.00 22.00 ? 137 LEU B C   1 
ATOM   3264 O  O   . LEU B 1 132 ? -13.999 -29.915 25.830  1.00 22.43 ? 137 LEU B O   1 
ATOM   3265 C  CB  . LEU B 1 132 ? -16.807 -31.465 24.712  1.00 22.14 ? 137 LEU B CB  1 
ATOM   3266 C  CG  . LEU B 1 132 ? -17.469 -30.979 26.009  1.00 21.93 ? 137 LEU B CG  1 
ATOM   3267 C  CD1 . LEU B 1 132 ? -17.284 -29.505 26.198  1.00 25.83 ? 137 LEU B CD1 1 
ATOM   3268 C  CD2 . LEU B 1 132 ? -18.939 -31.212 25.882  1.00 20.37 ? 137 LEU B CD2 1 
ATOM   3269 N  N   . CYS B 1 133 ? -14.690 -29.265 23.803  1.00 21.75 ? 138 CYS B N   1 
ATOM   3270 C  CA  . CYS B 1 133 ? -14.359 -27.877 24.012  1.00 19.83 ? 138 CYS B CA  1 
ATOM   3271 C  C   . CYS B 1 133 ? -15.582 -27.053 23.625  1.00 18.33 ? 138 CYS B C   1 
ATOM   3272 O  O   . CYS B 1 133 ? -16.493 -27.530 22.956  1.00 17.90 ? 138 CYS B O   1 
ATOM   3273 C  CB  . CYS B 1 133 ? -13.151 -27.465 23.198  1.00 20.97 ? 138 CYS B CB  1 
ATOM   3274 S  SG  . CYS B 1 133 ? -13.482 -27.667 21.449  1.00 22.78 ? 138 CYS B SG  1 
ATOM   3275 N  N   . VAL B 1 134 ? -15.621 -25.811 24.089  1.00 17.76 ? 139 VAL B N   1 
ATOM   3276 C  CA  . VAL B 1 134 ? -16.855 -25.045 23.986  1.00 15.94 ? 139 VAL B CA  1 
ATOM   3277 C  C   . VAL B 1 134 ? -16.538 -23.736 23.263  1.00 16.40 ? 139 VAL B C   1 
ATOM   3278 O  O   . VAL B 1 134 ? -15.613 -23.057 23.634  1.00 15.95 ? 139 VAL B O   1 
ATOM   3279 C  CB  . VAL B 1 134 ? -17.395 -24.710 25.373  1.00 16.51 ? 139 VAL B CB  1 
ATOM   3280 C  CG1 . VAL B 1 134 ? -18.625 -23.807 25.276  1.00 15.02 ? 139 VAL B CG1 1 
ATOM   3281 C  CG2 . VAL B 1 134 ? -17.729 -26.009 26.184  1.00 16.50 ? 139 VAL B CG2 1 
ATOM   3282 N  N   . VAL B 1 135 ? -17.314 -23.417 22.230  1.00 15.89 ? 140 VAL B N   1 
ATOM   3283 C  CA  . VAL B 1 135 ? -17.262 -22.100 21.623  1.00 15.42 ? 140 VAL B CA  1 
ATOM   3284 C  C   . VAL B 1 135 ? -18.537 -21.379 22.035  1.00 14.68 ? 140 VAL B C   1 
ATOM   3285 O  O   . VAL B 1 135 ? -19.634 -21.787 21.660  1.00 15.08 ? 140 VAL B O   1 
ATOM   3286 C  CB  . VAL B 1 135 ? -17.041 -22.162 20.105  1.00 14.98 ? 140 VAL B CB  1 
ATOM   3287 C  CG1 . VAL B 1 135 ? -16.953 -20.742 19.562  1.00 16.04 ? 140 VAL B CG1 1 
ATOM   3288 C  CG2 . VAL B 1 135 ? -15.681 -22.849 19.817  1.00 16.11 ? 140 VAL B CG2 1 
ATOM   3289 N  N   . TRP B 1 136 ? -18.379 -20.328 22.838  1.00 14.93 ? 141 TRP B N   1 
ATOM   3290 C  CA  . TRP B 1 136 ? -19.543 -19.615 23.405  1.00 15.77 ? 141 TRP B CA  1 
ATOM   3291 C  C   . TRP B 1 136 ? -19.711 -18.280 22.675  1.00 15.18 ? 141 TRP B C   1 
ATOM   3292 O  O   . TRP B 1 136 ? -18.913 -17.378 22.848  1.00 16.84 ? 141 TRP B O   1 
ATOM   3293 C  CB  . TRP B 1 136 ? -19.327 -19.374 24.920  1.00 15.37 ? 141 TRP B CB  1 
ATOM   3294 C  CG  . TRP B 1 136 ? -20.572 -18.961 25.677  1.00 18.73 ? 141 TRP B CG  1 
ATOM   3295 C  CD1 . TRP B 1 136 ? -21.136 -17.710 25.721  1.00 16.04 ? 141 TRP B CD1 1 
ATOM   3296 C  CD2 . TRP B 1 136 ? -21.379 -19.789 26.519  1.00 18.48 ? 141 TRP B CD2 1 
ATOM   3297 N  NE1 . TRP B 1 136 ? -22.241 -17.716 26.527  1.00 19.76 ? 141 TRP B NE1 1 
ATOM   3298 C  CE2 . TRP B 1 136 ? -22.406 -18.969 27.052  1.00 20.04 ? 141 TRP B CE2 1 
ATOM   3299 C  CE3 . TRP B 1 136 ? -21.317 -21.136 26.908  1.00 20.05 ? 141 TRP B CE3 1 
ATOM   3300 C  CZ2 . TRP B 1 136 ? -23.402 -19.465 27.930  1.00 18.88 ? 141 TRP B CZ2 1 
ATOM   3301 C  CZ3 . TRP B 1 136 ? -22.295 -21.625 27.772  1.00 18.40 ? 141 TRP B CZ3 1 
ATOM   3302 C  CH2 . TRP B 1 136 ? -23.329 -20.795 28.264  1.00 18.24 ? 141 TRP B CH2 1 
ATOM   3303 N  N   . VAL B 1 137 ? -20.751 -18.182 21.860  1.00 16.06 ? 142 VAL B N   1 
ATOM   3304 C  CA  . VAL B 1 137 ? -20.942 -17.016 20.989  1.00 14.47 ? 142 VAL B CA  1 
ATOM   3305 C  C   . VAL B 1 137 ? -22.079 -16.224 21.588  1.00 14.16 ? 142 VAL B C   1 
ATOM   3306 O  O   . VAL B 1 137 ? -23.207 -16.675 21.608  1.00 14.52 ? 142 VAL B O   1 
ATOM   3307 C  CB  . VAL B 1 137 ? -21.221 -17.399 19.515  1.00 14.09 ? 142 VAL B CB  1 
ATOM   3308 C  CG1 . VAL B 1 137 ? -21.305 -16.113 18.666  1.00 12.50 ? 142 VAL B CG1 1 
ATOM   3309 C  CG2 . VAL B 1 137 ? -20.120 -18.306 18.966  1.00 14.80 ? 142 VAL B CG2 1 
ATOM   3310 N  N   . ASP B 1 138 ? -21.772 -15.023 22.060  1.00 14.40 ? 143 ASP B N   1 
ATOM   3311 C  CA  . ASP B 1 138 ? -22.707 -14.336 22.941  1.00 14.18 ? 143 ASP B CA  1 
ATOM   3312 C  C   . ASP B 1 138 ? -22.207 -12.907 23.131  1.00 13.39 ? 143 ASP B C   1 
ATOM   3313 O  O   . ASP B 1 138 ? -20.990 -12.666 23.157  1.00 13.51 ? 143 ASP B O   1 
ATOM   3314 C  CB  . ASP B 1 138 ? -22.680 -15.092 24.299  1.00 13.43 ? 143 ASP B CB  1 
ATOM   3315 C  CG  . ASP B 1 138 ? -23.942 -14.897 25.136  1.00 15.89 ? 143 ASP B CG  1 
ATOM   3316 O  OD1 . ASP B 1 138 ? -24.527 -13.791 25.149  1.00 15.14 ? 143 ASP B OD1 1 
ATOM   3317 O  OD2 . ASP B 1 138 ? -24.318 -15.879 25.826  1.00 15.54 ? 143 ASP B OD2 1 
ATOM   3318 N  N   . ALA B 1 139 ? -23.126 -11.968 23.300  1.00 14.21 ? 144 ALA B N   1 
ATOM   3319 C  CA  . ALA B 1 139 ? -22.781 -10.612 23.807  1.00 14.65 ? 144 ALA B CA  1 
ATOM   3320 C  C   . ALA B 1 139 ? -22.275 -10.696 25.260  1.00 16.22 ? 144 ALA B C   1 
ATOM   3321 O  O   . ALA B 1 139 ? -21.502 -9.829  25.728  1.00 16.27 ? 144 ALA B O   1 
ATOM   3322 C  CB  . ALA B 1 139 ? -24.006 -9.661  23.717  1.00 15.45 ? 144 ALA B CB  1 
ATOM   3323 N  N   . HIS B 1 140 ? -22.657 -11.778 25.937  1.00 16.54 ? 145 HIS B N   1 
ATOM   3324 C  CA  . HIS B 1 140 ? -22.478 -11.936 27.376  1.00 17.84 ? 145 HIS B CA  1 
ATOM   3325 C  C   . HIS B 1 140 ? -21.605 -13.132 27.738  1.00 18.47 ? 145 HIS B C   1 
ATOM   3326 O  O   . HIS B 1 140 ? -21.584 -14.153 27.027  1.00 18.72 ? 145 HIS B O   1 
ATOM   3327 C  CB  . HIS B 1 140 ? -23.847 -12.111 28.016  1.00 17.09 ? 145 HIS B CB  1 
ATOM   3328 C  CG  . HIS B 1 140 ? -24.801 -11.021 27.657  1.00 18.36 ? 145 HIS B CG  1 
ATOM   3329 N  ND1 . HIS B 1 140 ? -25.833 -11.196 26.760  1.00 17.39 ? 145 HIS B ND1 1 
ATOM   3330 C  CD2 . HIS B 1 140 ? -24.853 -9.724  28.048  1.00 16.29 ? 145 HIS B CD2 1 
ATOM   3331 C  CE1 . HIS B 1 140 ? -26.501 -10.062 26.638  1.00 19.94 ? 145 HIS B CE1 1 
ATOM   3332 N  NE2 . HIS B 1 140 ? -25.938 -9.160  27.426  1.00 19.99 ? 145 HIS B NE2 1 
ATOM   3333 N  N   . ALA B 1 141 ? -20.837 -13.001 28.810  1.00 18.71 ? 146 ALA B N   1 
ATOM   3334 C  CA  . ALA B 1 141 ? -20.012 -14.128 29.248  1.00 19.76 ? 146 ALA B CA  1 
ATOM   3335 C  C   . ALA B 1 141 ? -20.795 -15.160 30.059  1.00 20.40 ? 146 ALA B C   1 
ATOM   3336 O  O   . ALA B 1 141 ? -20.377 -16.313 30.143  1.00 21.17 ? 146 ALA B O   1 
ATOM   3337 C  CB  . ALA B 1 141 ? -18.767 -13.653 30.019  1.00 20.03 ? 146 ALA B CB  1 
ATOM   3338 N  N   . ASP B 1 142 ? -21.934 -14.761 30.647  1.00 20.42 ? 147 ASP B N   1 
ATOM   3339 C  CA  . ASP B 1 142 ? -22.785 -15.702 31.384  1.00 21.04 ? 147 ASP B CA  1 
ATOM   3340 C  C   . ASP B 1 142 ? -22.002 -16.547 32.406  1.00 21.46 ? 147 ASP B C   1 
ATOM   3341 O  O   . ASP B 1 142 ? -22.212 -17.757 32.513  1.00 21.26 ? 147 ASP B O   1 
ATOM   3342 C  CB  . ASP B 1 142 ? -23.490 -16.627 30.382  1.00 20.63 ? 147 ASP B CB  1 
ATOM   3343 C  CG  . ASP B 1 142 ? -24.483 -15.884 29.508  1.00 21.62 ? 147 ASP B CG  1 
ATOM   3344 O  OD1 . ASP B 1 142 ? -24.781 -14.705 29.798  1.00 23.55 ? 147 ASP B OD1 1 
ATOM   3345 O  OD2 . ASP B 1 142 ? -24.984 -16.482 28.542  1.00 21.83 ? 147 ASP B OD2 1 
ATOM   3346 N  N   . ILE B 1 143 ? -21.084 -15.907 33.122  1.00 21.34 ? 148 ILE B N   1 
ATOM   3347 C  CA  . ILE B 1 143 ? -20.184 -16.591 34.021  1.00 21.47 ? 148 ILE B CA  1 
ATOM   3348 C  C   . ILE B 1 143 ? -20.262 -15.994 35.433  1.00 22.82 ? 148 ILE B C   1 
ATOM   3349 O  O   . ILE B 1 143 ? -19.331 -16.156 36.225  1.00 23.71 ? 148 ILE B O   1 
ATOM   3350 C  CB  . ILE B 1 143 ? -18.740 -16.592 33.464  1.00 21.55 ? 148 ILE B CB  1 
ATOM   3351 C  CG1 . ILE B 1 143 ? -17.899 -17.700 34.121  1.00 21.69 ? 148 ILE B CG1 1 
ATOM   3352 C  CG2 . ILE B 1 143 ? -18.055 -15.194 33.551  1.00 20.51 ? 148 ILE B CG2 1 
ATOM   3353 C  CD1 . ILE B 1 143 ? -16.608 -18.022 33.355  1.00 21.75 ? 148 ILE B CD1 1 
ATOM   3354 N  N   . ASN B 1 144 ? -21.353 -15.278 35.728  1.00 23.11 ? 149 ASN B N   1 
ATOM   3355 C  CA  . ASN B 1 144 ? -21.598 -14.828 37.106  1.00 24.47 ? 149 ASN B CA  1 
ATOM   3356 C  C   . ASN B 1 144 ? -21.797 -16.093 37.952  1.00 25.35 ? 149 ASN B C   1 
ATOM   3357 O  O   . ASN B 1 144 ? -22.377 -17.070 37.461  1.00 25.04 ? 149 ASN B O   1 
ATOM   3358 C  CB  . ASN B 1 144 ? -22.857 -13.961 37.190  1.00 23.85 ? 149 ASN B CB  1 
ATOM   3359 C  CG  . ASN B 1 144 ? -22.571 -12.463 37.008  1.00 24.60 ? 149 ASN B CG  1 
ATOM   3360 O  OD1 . ASN B 1 144 ? -21.665 -11.908 37.639  1.00 23.95 ? 149 ASN B OD1 1 
ATOM   3361 N  ND2 . ASN B 1 144 ? -23.355 -11.809 36.141  1.00 20.21 ? 149 ASN B ND2 1 
ATOM   3362 N  N   . THR B 1 145 ? -21.327 -16.062 39.199  1.00 25.88 ? 150 THR B N   1 
ATOM   3363 C  CA  . THR B 1 145 ? -21.675 -17.096 40.195  1.00 27.38 ? 150 THR B CA  1 
ATOM   3364 C  C   . THR B 1 145 ? -23.009 -16.731 40.869  1.00 28.03 ? 150 THR B C   1 
ATOM   3365 O  O   . THR B 1 145 ? -23.478 -15.595 40.722  1.00 28.34 ? 150 THR B O   1 
ATOM   3366 C  CB  . THR B 1 145 ? -20.589 -17.212 41.280  1.00 27.67 ? 150 THR B CB  1 
ATOM   3367 O  OG1 . THR B 1 145 ? -20.686 -16.074 42.159  1.00 28.01 ? 150 THR B OG1 1 
ATOM   3368 C  CG2 . THR B 1 145 ? -19.186 -17.275 40.650  1.00 26.52 ? 150 THR B CG2 1 
ATOM   3369 N  N   . PRO B 1 146 ? -23.631 -17.676 41.617  1.00 29.11 ? 151 PRO B N   1 
ATOM   3370 C  CA  . PRO B 1 146 ? -24.873 -17.333 42.343  1.00 29.19 ? 151 PRO B CA  1 
ATOM   3371 C  C   . PRO B 1 146 ? -24.687 -16.213 43.380  1.00 29.28 ? 151 PRO B C   1 
ATOM   3372 O  O   . PRO B 1 146 ? -25.676 -15.619 43.826  1.00 29.41 ? 151 PRO B O   1 
ATOM   3373 C  CB  . PRO B 1 146 ? -25.237 -18.650 43.038  1.00 29.97 ? 151 PRO B CB  1 
ATOM   3374 C  CG  . PRO B 1 146 ? -24.676 -19.719 42.098  1.00 29.34 ? 151 PRO B CG  1 
ATOM   3375 C  CD  . PRO B 1 146 ? -23.345 -19.125 41.685  1.00 29.12 ? 151 PRO B CD  1 
ATOM   3376 N  N   . LEU B 1 147 ? -23.424 -15.950 43.726  1.00 29.31 ? 152 LEU B N   1 
ATOM   3377 C  CA  . LEU B 1 147 ? -23.015 -14.901 44.649  1.00 29.65 ? 152 LEU B CA  1 
ATOM   3378 C  C   . LEU B 1 147 ? -22.664 -13.572 43.978  1.00 30.18 ? 152 LEU B C   1 
ATOM   3379 O  O   . LEU B 1 147 ? -22.749 -12.523 44.638  1.00 30.05 ? 152 LEU B O   1 
ATOM   3380 C  CB  . LEU B 1 147 ? -21.829 -15.369 45.512  1.00 29.93 ? 152 LEU B CB  1 
ATOM   3381 C  CG  . LEU B 1 147 ? -22.116 -16.630 46.344  1.00 29.15 ? 152 LEU B CG  1 
ATOM   3382 C  CD1 . LEU B 1 147 ? -20.964 -16.950 47.276  1.00 29.18 ? 152 LEU B CD1 1 
ATOM   3383 C  CD2 . LEU B 1 147 ? -23.410 -16.454 47.102  1.00 31.11 ? 152 LEU B CD2 1 
ATOM   3384 N  N   . THR B 1 148 ? -22.284 -13.585 42.696  1.00 29.64 ? 153 THR B N   1 
ATOM   3385 C  CA  . THR B 1 148 ? -21.948 -12.319 42.001  1.00 29.72 ? 153 THR B CA  1 
ATOM   3386 C  C   . THR B 1 148 ? -23.065 -11.719 41.156  1.00 30.42 ? 153 THR B C   1 
ATOM   3387 O  O   . THR B 1 148 ? -22.983 -10.561 40.761  1.00 31.20 ? 153 THR B O   1 
ATOM   3388 C  CB  . THR B 1 148 ? -20.695 -12.418 41.100  1.00 30.11 ? 153 THR B CB  1 
ATOM   3389 O  OG1 . THR B 1 148 ? -20.968 -13.295 40.005  1.00 27.86 ? 153 THR B OG1 1 
ATOM   3390 C  CG2 . THR B 1 148 ? -19.466 -12.893 41.883  1.00 29.97 ? 153 THR B CG2 1 
ATOM   3391 N  N   . THR B 1 149 ? -24.104 -12.487 40.873  1.00 31.02 ? 154 THR B N   1 
ATOM   3392 C  CA  . THR B 1 149 ? -25.188 -12.010 40.023  1.00 31.80 ? 154 THR B CA  1 
ATOM   3393 C  C   . THR B 1 149 ? -25.926 -10.871 40.732  1.00 33.10 ? 154 THR B C   1 
ATOM   3394 O  O   . THR B 1 149 ? -26.068 -10.883 41.965  1.00 33.13 ? 154 THR B O   1 
ATOM   3395 C  CB  . THR B 1 149 ? -26.156 -13.146 39.687  1.00 31.38 ? 154 THR B CB  1 
ATOM   3396 O  OG1 . THR B 1 149 ? -27.259 -12.646 38.918  1.00 33.23 ? 154 THR B OG1 1 
ATOM   3397 C  CG2 . THR B 1 149 ? -26.688 -13.789 40.970  1.00 32.06 ? 154 THR B CG2 1 
ATOM   3398 N  N   . SER B 1 150 ? -26.349 -9.882  39.945  1.00 33.79 ? 155 SER B N   1 
ATOM   3399 C  CA  . SER B 1 150 ? -27.117 -8.746  40.434  1.00 34.70 ? 155 SER B CA  1 
ATOM   3400 C  C   . SER B 1 150 ? -28.567 -9.034  40.147  1.00 34.73 ? 155 SER B C   1 
ATOM   3401 O  O   . SER B 1 150 ? -29.447 -8.691  40.942  1.00 35.84 ? 155 SER B O   1 
ATOM   3402 C  CB  . SER B 1 150 ? -26.710 -7.464  39.704  1.00 34.65 ? 155 SER B CB  1 
ATOM   3403 O  OG  . SER B 1 150 ? -25.310 -7.230  39.810  1.00 37.65 ? 155 SER B OG  1 
ATOM   3404 N  N   . SER B 1 151 ? -28.814 -9.677  39.008  1.00 33.60 ? 156 SER B N   1 
ATOM   3405 C  CA  . SER B 1 151 ? -30.172 -9.922  38.544  1.00 33.20 ? 156 SER B CA  1 
ATOM   3406 C  C   . SER B 1 151 ? -30.801 -11.109 39.255  1.00 32.87 ? 156 SER B C   1 
ATOM   3407 O  O   . SER B 1 151 ? -32.026 -11.169 39.395  1.00 32.87 ? 156 SER B O   1 
ATOM   3408 C  CB  . SER B 1 151 ? -30.169 -10.193 37.034  1.00 33.33 ? 156 SER B CB  1 
ATOM   3409 O  OG  . SER B 1 151 ? -29.619 -11.481 36.754  1.00 32.64 ? 156 SER B OG  1 
ATOM   3410 N  N   . GLY B 1 152 ? -29.962 -12.054 39.681  1.00 32.19 ? 157 GLY B N   1 
ATOM   3411 C  CA  . GLY B 1 152 ? -30.424 -13.379 40.116  1.00 31.88 ? 157 GLY B CA  1 
ATOM   3412 C  C   . GLY B 1 152 ? -30.874 -14.329 39.000  1.00 31.31 ? 157 GLY B C   1 
ATOM   3413 O  O   . GLY B 1 152 ? -31.325 -15.452 39.289  1.00 32.07 ? 157 GLY B O   1 
ATOM   3414 N  N   . ASN B 1 153 ? -30.778 -13.880 37.740  1.00 30.12 ? 158 ASN B N   1 
ATOM   3415 C  CA  . ASN B 1 153 ? -31.201 -14.661 36.570  1.00 28.88 ? 158 ASN B CA  1 
ATOM   3416 C  C   . ASN B 1 153 ? -30.191 -15.750 36.219  1.00 27.78 ? 158 ASN B C   1 
ATOM   3417 O  O   . ASN B 1 153 ? -28.996 -15.484 35.987  1.00 27.72 ? 158 ASN B O   1 
ATOM   3418 C  CB  . ASN B 1 153 ? -31.462 -13.772 35.347  1.00 28.68 ? 158 ASN B CB  1 
ATOM   3419 C  CG  . ASN B 1 153 ? -32.603 -12.782 35.560  1.00 30.24 ? 158 ASN B CG  1 
ATOM   3420 O  OD1 . ASN B 1 153 ? -33.571 -13.053 36.280  1.00 32.19 ? 158 ASN B OD1 1 
ATOM   3421 N  ND2 . ASN B 1 153 ? -32.505 -11.639 34.904  1.00 29.92 ? 158 ASN B ND2 1 
ATOM   3422 N  N   . LEU B 1 154 ? -30.660 -16.994 36.228  1.00 26.84 ? 159 LEU B N   1 
ATOM   3423 C  CA  . LEU B 1 154 ? -29.749 -18.115 36.037  1.00 25.43 ? 159 LEU B CA  1 
ATOM   3424 C  C   . LEU B 1 154 ? -29.133 -18.162 34.625  1.00 24.10 ? 159 LEU B C   1 
ATOM   3425 O  O   . LEU B 1 154 ? -28.038 -18.703 34.467  1.00 24.66 ? 159 LEU B O   1 
ATOM   3426 C  CB  . LEU B 1 154 ? -30.417 -19.431 36.434  1.00 26.13 ? 159 LEU B CB  1 
ATOM   3427 C  CG  . LEU B 1 154 ? -30.423 -19.619 37.972  1.00 26.58 ? 159 LEU B CG  1 
ATOM   3428 C  CD1 . LEU B 1 154 ? -31.497 -20.593 38.381  1.00 28.32 ? 159 LEU B CD1 1 
ATOM   3429 C  CD2 . LEU B 1 154 ? -29.055 -20.074 38.500  1.00 25.30 ? 159 LEU B CD2 1 
ATOM   3430 N  N   . HIS B 1 155 ? -29.793 -17.544 33.637  1.00 23.60 ? 160 HIS B N   1 
ATOM   3431 C  CA  . HIS B 1 155 ? -29.213 -17.472 32.260  1.00 22.15 ? 160 HIS B CA  1 
ATOM   3432 C  C   . HIS B 1 155 ? -27.905 -16.701 32.192  1.00 22.10 ? 160 HIS B C   1 
ATOM   3433 O  O   . HIS B 1 155 ? -27.193 -16.776 31.185  1.00 21.15 ? 160 HIS B O   1 
ATOM   3434 C  CB  . HIS B 1 155 ? -30.219 -17.054 31.173  1.00 22.32 ? 160 HIS B CB  1 
ATOM   3435 C  CG  . HIS B 1 155 ? -30.526 -15.585 31.117  1.00 22.25 ? 160 HIS B CG  1 
ATOM   3436 N  ND1 . HIS B 1 155 ? -31.135 -15.002 30.025  1.00 21.32 ? 160 HIS B ND1 1 
ATOM   3437 C  CD2 . HIS B 1 155 ? -30.327 -14.586 32.015  1.00 24.26 ? 160 HIS B CD2 1 
ATOM   3438 C  CE1 . HIS B 1 155 ? -31.309 -13.710 30.255  1.00 23.89 ? 160 HIS B CE1 1 
ATOM   3439 N  NE2 . HIS B 1 155 ? -30.821 -13.431 31.453  1.00 24.35 ? 160 HIS B NE2 1 
ATOM   3440 N  N   . GLY B 1 156 ? -27.566 -16.018 33.288  1.00 21.26 ? 161 GLY B N   1 
ATOM   3441 C  CA  . GLY B 1 156 ? -26.348 -15.227 33.363  1.00 21.35 ? 161 GLY B CA  1 
ATOM   3442 C  C   . GLY B 1 156 ? -25.255 -15.896 34.153  1.00 21.33 ? 161 GLY B C   1 
ATOM   3443 O  O   . GLY B 1 156 ? -24.202 -15.312 34.376  1.00 21.32 ? 161 GLY B O   1 
ATOM   3444 N  N   . GLN B 1 157 ? -25.536 -17.123 34.609  1.00 21.99 ? 162 GLN B N   1 
ATOM   3445 C  CA  . GLN B 1 157 ? -24.620 -17.886 35.445  1.00 21.48 ? 162 GLN B CA  1 
ATOM   3446 C  C   . GLN B 1 157 ? -24.185 -19.283 34.910  1.00 21.50 ? 162 GLN B C   1 
ATOM   3447 O  O   . GLN B 1 157 ? -23.344 -19.927 35.541  1.00 22.38 ? 162 GLN B O   1 
ATOM   3448 C  CB  . GLN B 1 157 ? -25.244 -18.074 36.844  1.00 21.25 ? 162 GLN B CB  1 
ATOM   3449 C  CG  . GLN B 1 157 ? -25.666 -16.774 37.564  1.00 22.47 ? 162 GLN B CG  1 
ATOM   3450 C  CD  . GLN B 1 157 ? -26.635 -17.052 38.704  1.00 24.37 ? 162 GLN B CD  1 
ATOM   3451 O  OE1 . GLN B 1 157 ? -26.311 -17.809 39.616  1.00 25.37 ? 162 GLN B OE1 1 
ATOM   3452 N  NE2 . GLN B 1 157 ? -27.842 -16.467 38.639  1.00 23.28 ? 162 GLN B NE2 1 
ATOM   3453 N  N   . PRO B 1 158 ? -24.721 -19.755 33.754  1.00 21.65 ? 163 PRO B N   1 
ATOM   3454 C  CA  . PRO B 1 158 ? -24.534 -21.207 33.462  1.00 21.44 ? 163 PRO B CA  1 
ATOM   3455 C  C   . PRO B 1 158 ? -23.087 -21.672 33.464  1.00 22.31 ? 163 PRO B C   1 
ATOM   3456 O  O   . PRO B 1 158 ? -22.782 -22.784 33.928  1.00 22.83 ? 163 PRO B O   1 
ATOM   3457 C  CB  . PRO B 1 158 ? -25.144 -21.373 32.062  1.00 21.09 ? 163 PRO B CB  1 
ATOM   3458 C  CG  . PRO B 1 158 ? -25.066 -20.034 31.437  1.00 20.60 ? 163 PRO B CG  1 
ATOM   3459 C  CD  . PRO B 1 158 ? -25.370 -19.082 32.618  1.00 21.31 ? 163 PRO B CD  1 
ATOM   3460 N  N   . VAL B 1 159 ? -22.188 -20.807 33.006  1.00 22.05 ? 164 VAL B N   1 
ATOM   3461 C  CA  . VAL B 1 159 ? -20.795 -21.177 32.888  1.00 22.02 ? 164 VAL B CA  1 
ATOM   3462 C  C   . VAL B 1 159 ? -20.103 -21.352 34.247  1.00 23.18 ? 164 VAL B C   1 
ATOM   3463 O  O   . VAL B 1 159 ? -19.192 -22.183 34.364  1.00 23.68 ? 164 VAL B O   1 
ATOM   3464 C  CB  . VAL B 1 159 ? -20.032 -20.217 31.965  1.00 22.05 ? 164 VAL B CB  1 
ATOM   3465 C  CG1 . VAL B 1 159 ? -18.588 -20.617 31.841  1.00 21.69 ? 164 VAL B CG1 1 
ATOM   3466 C  CG2 . VAL B 1 159 ? -20.692 -20.192 30.581  1.00 20.04 ? 164 VAL B CG2 1 
ATOM   3467 N  N   . SER B 1 160 ? -20.541 -20.609 35.270  1.00 22.79 ? 165 SER B N   1 
ATOM   3468 C  CA  . SER B 1 160 ? -19.985 -20.819 36.618  1.00 23.78 ? 165 SER B CA  1 
ATOM   3469 C  C   . SER B 1 160 ? -20.201 -22.253 37.098  1.00 23.83 ? 165 SER B C   1 
ATOM   3470 O  O   . SER B 1 160 ? -19.290 -22.844 37.646  1.00 23.28 ? 165 SER B O   1 
ATOM   3471 C  CB  . SER B 1 160 ? -20.507 -19.808 37.662  1.00 23.08 ? 165 SER B CB  1 
ATOM   3472 O  OG  . SER B 1 160 ? -21.905 -19.959 37.869  1.00 24.37 ? 165 SER B OG  1 
ATOM   3473 N  N   . PHE B 1 161 ? -21.399 -22.800 36.903  1.00 25.12 ? 166 PHE B N   1 
ATOM   3474 C  CA  . PHE B 1 161 ? -21.701 -24.190 37.346  1.00 26.28 ? 166 PHE B CA  1 
ATOM   3475 C  C   . PHE B 1 161 ? -20.889 -25.257 36.601  1.00 26.43 ? 166 PHE B C   1 
ATOM   3476 O  O   . PHE B 1 161 ? -20.667 -26.347 37.121  1.00 26.75 ? 166 PHE B O   1 
ATOM   3477 C  CB  . PHE B 1 161 ? -23.181 -24.502 37.164  1.00 26.19 ? 166 PHE B CB  1 
ATOM   3478 C  CG  . PHE B 1 161 ? -24.094 -23.590 37.926  1.00 28.54 ? 166 PHE B CG  1 
ATOM   3479 C  CD1 . PHE B 1 161 ? -24.705 -22.515 37.287  1.00 28.91 ? 166 PHE B CD1 1 
ATOM   3480 C  CD2 . PHE B 1 161 ? -24.326 -23.790 39.290  1.00 28.69 ? 166 PHE B CD2 1 
ATOM   3481 C  CE1 . PHE B 1 161 ? -25.550 -21.646 37.984  1.00 28.40 ? 166 PHE B CE1 1 
ATOM   3482 C  CE2 . PHE B 1 161 ? -25.184 -22.928 40.004  1.00 30.32 ? 166 PHE B CE2 1 
ATOM   3483 C  CZ  . PHE B 1 161 ? -25.794 -21.853 39.339  1.00 29.51 ? 166 PHE B CZ  1 
ATOM   3484 N  N   . LEU B 1 162 ? -20.475 -24.960 35.369  1.00 26.53 ? 167 LEU B N   1 
ATOM   3485 C  CA  . LEU B 1 162 ? -19.816 -25.953 34.502  1.00 26.53 ? 167 LEU B CA  1 
ATOM   3486 C  C   . LEU B 1 162 ? -18.300 -25.950 34.623  1.00 27.08 ? 167 LEU B C   1 
ATOM   3487 O  O   . LEU B 1 162 ? -17.650 -26.945 34.325  1.00 27.87 ? 167 LEU B O   1 
ATOM   3488 C  CB  . LEU B 1 162 ? -20.226 -25.741 33.030  1.00 25.56 ? 167 LEU B CB  1 
ATOM   3489 C  CG  . LEU B 1 162 ? -21.714 -25.945 32.783  1.00 26.53 ? 167 LEU B CG  1 
ATOM   3490 C  CD1 . LEU B 1 162 ? -22.132 -25.405 31.407  1.00 24.38 ? 167 LEU B CD1 1 
ATOM   3491 C  CD2 . LEU B 1 162 ? -22.035 -27.426 32.907  1.00 24.60 ? 167 LEU B CD2 1 
ATOM   3492 N  N   . LEU B 1 163 ? -17.739 -24.843 35.083  1.00 27.86 ? 168 LEU B N   1 
ATOM   3493 C  CA  . LEU B 1 163 ? -16.295 -24.651 35.047  1.00 28.74 ? 168 LEU B CA  1 
ATOM   3494 C  C   . LEU B 1 163 ? -15.583 -25.257 36.251  1.00 29.75 ? 168 LEU B C   1 
ATOM   3495 O  O   . LEU B 1 163 ? -15.946 -24.951 37.396  1.00 29.47 ? 168 LEU B O   1 
ATOM   3496 C  CB  . LEU B 1 163 ? -15.987 -23.160 34.992  1.00 28.83 ? 168 LEU B CB  1 
ATOM   3497 C  CG  . LEU B 1 163 ? -14.671 -22.772 34.331  1.00 30.03 ? 168 LEU B CG  1 
ATOM   3498 C  CD1 . LEU B 1 163 ? -14.866 -22.797 32.826  1.00 29.28 ? 168 LEU B CD1 1 
ATOM   3499 C  CD2 . LEU B 1 163 ? -14.231 -21.383 34.789  1.00 31.31 ? 168 LEU B CD2 1 
ATOM   3500 N  N   . ARG B 1 164 ? -14.569 -26.087 35.983  1.00 30.49 ? 169 ARG B N   1 
ATOM   3501 C  CA  . ARG B 1 164 ? -13.853 -26.852 37.023  1.00 31.93 ? 169 ARG B CA  1 
ATOM   3502 C  C   . ARG B 1 164 ? -13.140 -25.988 38.046  1.00 31.84 ? 169 ARG B C   1 
ATOM   3503 O  O   . ARG B 1 164 ? -13.254 -26.228 39.256  1.00 32.05 ? 169 ARG B O   1 
ATOM   3504 C  CB  . ARG B 1 164 ? -12.816 -27.831 36.420  1.00 32.18 ? 169 ARG B CB  1 
ATOM   3505 C  CG  . ARG B 1 164 ? -13.392 -29.133 35.933  1.00 35.29 ? 169 ARG B CG  1 
ATOM   3506 C  CD  . ARG B 1 164 ? -12.295 -30.178 35.659  1.00 39.30 ? 169 ARG B CD  1 
ATOM   3507 N  NE  . ARG B 1 164 ? -12.535 -30.860 34.390  1.00 42.60 ? 169 ARG B NE  1 
ATOM   3508 C  CZ  . ARG B 1 164 ? -13.435 -31.823 34.195  1.00 45.57 ? 169 ARG B CZ  1 
ATOM   3509 N  NH1 . ARG B 1 164 ? -14.204 -32.250 35.194  1.00 47.96 ? 169 ARG B NH1 1 
ATOM   3510 N  NH2 . ARG B 1 164 ? -13.579 -32.363 32.992  1.00 45.51 ? 169 ARG B NH2 1 
ATOM   3511 N  N   . GLU B 1 165 ? -12.412 -24.989 37.550  1.00 32.37 ? 170 GLU B N   1 
ATOM   3512 C  CA  . GLU B 1 165 ? -11.525 -24.162 38.364  1.00 32.46 ? 170 GLU B CA  1 
ATOM   3513 C  C   . GLU B 1 165 ? -12.299 -23.210 39.267  1.00 32.66 ? 170 GLU B C   1 
ATOM   3514 O  O   . GLU B 1 165 ? -11.706 -22.506 40.090  1.00 33.30 ? 170 GLU B O   1 
ATOM   3515 C  CB  . GLU B 1 165 ? -10.580 -23.335 37.475  1.00 32.29 ? 170 GLU B CB  1 
ATOM   3516 C  CG  . GLU B 1 165 ? -9.438  -24.109 36.781  1.00 32.97 ? 170 GLU B CG  1 
ATOM   3517 C  CD  . GLU B 1 165 ? -9.837  -24.682 35.425  1.00 33.00 ? 170 GLU B CD  1 
ATOM   3518 O  OE1 . GLU B 1 165 ? -11.027 -24.608 35.054  1.00 30.38 ? 170 GLU B OE1 1 
ATOM   3519 O  OE2 . GLU B 1 165 ? -8.946  -25.204 34.717  1.00 34.44 ? 170 GLU B OE2 1 
ATOM   3520 N  N   . LEU B 1 166 ? -13.619 -23.195 39.114  1.00 32.90 ? 171 LEU B N   1 
ATOM   3521 C  CA  . LEU B 1 166 ? -14.463 -22.202 39.757  1.00 33.09 ? 171 LEU B CA  1 
ATOM   3522 C  C   . LEU B 1 166 ? -15.314 -22.803 40.876  1.00 33.30 ? 171 LEU B C   1 
ATOM   3523 O  O   . LEU B 1 166 ? -16.048 -22.080 41.559  1.00 32.84 ? 171 LEU B O   1 
ATOM   3524 C  CB  . LEU B 1 166 ? -15.363 -21.552 38.695  1.00 32.64 ? 171 LEU B CB  1 
ATOM   3525 C  CG  . LEU B 1 166 ? -15.824 -20.093 38.782  1.00 32.70 ? 171 LEU B CG  1 
ATOM   3526 C  CD1 . LEU B 1 166 ? -14.711 -19.140 39.199  1.00 30.60 ? 171 LEU B CD1 1 
ATOM   3527 C  CD2 . LEU B 1 166 ? -16.440 -19.635 37.442  1.00 30.93 ? 171 LEU B CD2 1 
ATOM   3528 N  N   . GLN B 1 167 ? -15.212 -24.120 41.061  1.00 33.50 ? 172 GLN B N   1 
ATOM   3529 C  CA  . GLN B 1 167 ? -16.118 -24.831 41.964  1.00 34.32 ? 172 GLN B CA  1 
ATOM   3530 C  C   . GLN B 1 167 ? -16.226 -24.330 43.409  1.00 34.16 ? 172 GLN B C   1 
ATOM   3531 O  O   . GLN B 1 167 ? -17.333 -24.250 43.962  1.00 34.17 ? 172 GLN B O   1 
ATOM   3532 C  CB  . GLN B 1 167 ? -15.893 -26.346 41.899  1.00 34.50 ? 172 GLN B CB  1 
ATOM   3533 C  CG  . GLN B 1 167 ? -17.096 -27.108 41.296  1.00 36.21 ? 172 GLN B CG  1 
ATOM   3534 C  CD  . GLN B 1 167 ? -18.158 -26.220 40.572  1.00 37.12 ? 172 GLN B CD  1 
ATOM   3535 O  OE1 . GLN B 1 167 ? -19.348 -26.286 40.903  1.00 36.69 ? 172 GLN B OE1 1 
ATOM   3536 N  NE2 . GLN B 1 167 ? -17.729 -25.418 39.567  1.00 37.91 ? 172 GLN B NE2 1 
ATOM   3537 N  N   . ASP B 1 168 ? -15.108 -23.941 43.994  1.00 34.92 ? 173 ASP B N   1 
ATOM   3538 C  CA  . ASP B 1 168 ? -15.120 -23.439 45.376  1.00 36.10 ? 173 ASP B CA  1 
ATOM   3539 C  C   . ASP B 1 168 ? -15.722 -22.020 45.549  1.00 36.36 ? 173 ASP B C   1 
ATOM   3540 O  O   . ASP B 1 168 ? -15.786 -21.492 46.683  1.00 36.14 ? 173 ASP B O   1 
ATOM   3541 C  CB  . ASP B 1 168 ? -13.716 -23.512 45.982  1.00 36.84 ? 173 ASP B CB  1 
ATOM   3542 C  CG  . ASP B 1 168 ? -12.726 -22.624 45.265  1.00 39.91 ? 173 ASP B CG  1 
ATOM   3543 O  OD1 . ASP B 1 168 ? -13.048 -22.154 44.144  1.00 43.99 ? 173 ASP B OD1 1 
ATOM   3544 O  OD2 . ASP B 1 168 ? -11.621 -22.396 45.808  1.00 41.85 ? 173 ASP B OD2 1 
ATOM   3545 N  N   . LYS B 1 169 ? -16.135 -21.389 44.441  1.00 35.79 ? 174 LYS B N   1 
ATOM   3546 C  CA  . LYS B 1 169 ? -16.743 -20.061 44.507  1.00 35.40 ? 174 LYS B CA  1 
ATOM   3547 C  C   . LYS B 1 169 ? -18.212 -20.168 44.235  1.00 35.02 ? 174 LYS B C   1 
ATOM   3548 O  O   . LYS B 1 169 ? -18.925 -19.171 44.302  1.00 35.60 ? 174 LYS B O   1 
ATOM   3549 C  CB  . LYS B 1 169 ? -16.141 -19.087 43.487  1.00 35.81 ? 174 LYS B CB  1 
ATOM   3550 C  CG  . LYS B 1 169 ? -14.637 -19.033 43.416  1.00 36.57 ? 174 LYS B CG  1 
ATOM   3551 C  CD  . LYS B 1 169 ? -14.048 -18.191 44.526  1.00 38.94 ? 174 LYS B CD  1 
ATOM   3552 C  CE  . LYS B 1 169 ? -12.537 -18.293 44.512  1.00 38.41 ? 174 LYS B CE  1 
ATOM   3553 N  NZ  . LYS B 1 169 ? -12.017 -17.844 45.835  1.00 42.36 ? 174 LYS B NZ  1 
ATOM   3554 N  N   . VAL B 1 170 ? -18.656 -21.374 43.898  1.00 34.93 ? 175 VAL B N   1 
ATOM   3555 C  CA  . VAL B 1 170 ? -20.058 -21.657 43.587  1.00 34.69 ? 175 VAL B CA  1 
ATOM   3556 C  C   . VAL B 1 170 ? -20.642 -22.466 44.737  1.00 35.44 ? 175 VAL B C   1 
ATOM   3557 O  O   . VAL B 1 170 ? -20.113 -23.532 45.066  1.00 34.77 ? 175 VAL B O   1 
ATOM   3558 C  CB  . VAL B 1 170 ? -20.204 -22.499 42.278  1.00 34.51 ? 175 VAL B CB  1 
ATOM   3559 C  CG1 . VAL B 1 170 ? -21.660 -22.855 42.012  1.00 33.57 ? 175 VAL B CG1 1 
ATOM   3560 C  CG2 . VAL B 1 170 ? -19.587 -21.779 41.081  1.00 34.17 ? 175 VAL B CG2 1 
ATOM   3561 N  N   . PRO B 1 171 ? -21.729 -21.965 45.346  1.00 36.16 ? 176 PRO B N   1 
ATOM   3562 C  CA  . PRO B 1 171 ? -22.377 -22.710 46.411  1.00 37.06 ? 176 PRO B CA  1 
ATOM   3563 C  C   . PRO B 1 171 ? -23.373 -23.716 45.827  1.00 38.03 ? 176 PRO B C   1 
ATOM   3564 O  O   . PRO B 1 171 ? -23.742 -23.601 44.648  1.00 38.12 ? 176 PRO B O   1 
ATOM   3565 C  CB  . PRO B 1 171 ? -23.080 -21.611 47.214  1.00 37.03 ? 176 PRO B CB  1 
ATOM   3566 C  CG  . PRO B 1 171 ? -23.369 -20.513 46.209  1.00 36.69 ? 176 PRO B CG  1 
ATOM   3567 C  CD  . PRO B 1 171 ? -22.405 -20.681 45.066  1.00 36.09 ? 176 PRO B CD  1 
ATOM   3568 N  N   . GLN B 1 172 ? -23.783 -24.698 46.634  1.00 38.65 ? 177 GLN B N   1 
ATOM   3569 C  CA  . GLN B 1 172 ? -24.718 -25.740 46.204  1.00 39.41 ? 177 GLN B CA  1 
ATOM   3570 C  C   . GLN B 1 172 ? -26.133 -25.199 46.268  1.00 38.82 ? 177 GLN B C   1 
ATOM   3571 O  O   . GLN B 1 172 ? -26.621 -24.873 47.343  1.00 39.37 ? 177 GLN B O   1 
ATOM   3572 C  CB  . GLN B 1 172 ? -24.553 -27.002 47.085  1.00 40.20 ? 177 GLN B CB  1 
ATOM   3573 C  CG  . GLN B 1 172 ? -25.708 -28.042 46.980  1.00 44.35 ? 177 GLN B CG  1 
ATOM   3574 C  CD  . GLN B 1 172 ? -25.647 -29.139 48.063  1.00 48.84 ? 177 GLN B CD  1 
ATOM   3575 O  OE1 . GLN B 1 172 ? -24.631 -29.827 48.198  1.00 50.14 ? 177 GLN B OE1 1 
ATOM   3576 N  NE2 . GLN B 1 172 ? -26.746 -29.310 48.826  1.00 48.91 ? 177 GLN B NE2 1 
ATOM   3577 N  N   . LEU B 1 173 ? -26.788 -25.069 45.119  1.00 38.03 ? 178 LEU B N   1 
ATOM   3578 C  CA  . LEU B 1 173 ? -28.155 -24.567 45.067  1.00 37.49 ? 178 LEU B CA  1 
ATOM   3579 C  C   . LEU B 1 173 ? -29.076 -25.766 45.051  1.00 37.30 ? 178 LEU B C   1 
ATOM   3580 O  O   . LEU B 1 173 ? -28.715 -26.800 44.478  1.00 37.37 ? 178 LEU B O   1 
ATOM   3581 C  CB  . LEU B 1 173 ? -28.392 -23.754 43.782  1.00 37.33 ? 178 LEU B CB  1 
ATOM   3582 C  CG  . LEU B 1 173 ? -28.222 -22.232 43.686  1.00 37.66 ? 178 LEU B CG  1 
ATOM   3583 C  CD1 . LEU B 1 173 ? -26.846 -21.790 44.114  1.00 36.61 ? 178 LEU B CD1 1 
ATOM   3584 C  CD2 . LEU B 1 173 ? -28.509 -21.734 42.265  1.00 36.95 ? 178 LEU B CD2 1 
ATOM   3585 N  N   . PRO B 1 174 ? -30.279 -25.644 45.658  1.00 37.34 ? 179 PRO B N   1 
ATOM   3586 C  CA  . PRO B 1 174 ? -31.254 -26.718 45.492  1.00 36.94 ? 179 PRO B CA  1 
ATOM   3587 C  C   . PRO B 1 174 ? -31.445 -27.044 44.015  1.00 36.40 ? 179 PRO B C   1 
ATOM   3588 O  O   . PRO B 1 174 ? -31.740 -26.153 43.228  1.00 36.42 ? 179 PRO B O   1 
ATOM   3589 C  CB  . PRO B 1 174 ? -32.550 -26.103 46.054  1.00 36.99 ? 179 PRO B CB  1 
ATOM   3590 C  CG  . PRO B 1 174 ? -32.281 -24.570 46.095  1.00 37.26 ? 179 PRO B CG  1 
ATOM   3591 C  CD  . PRO B 1 174 ? -30.832 -24.548 46.478  1.00 37.44 ? 179 PRO B CD  1 
ATOM   3592 N  N   . GLY B 1 175 ? -31.282 -28.312 43.653  1.00 35.95 ? 180 GLY B N   1 
ATOM   3593 C  CA  . GLY B 1 175 ? -31.571 -28.762 42.287  1.00 35.34 ? 180 GLY B CA  1 
ATOM   3594 C  C   . GLY B 1 175 ? -30.370 -28.826 41.365  1.00 35.15 ? 180 GLY B C   1 
ATOM   3595 O  O   . GLY B 1 175 ? -30.517 -29.187 40.191  1.00 34.76 ? 180 GLY B O   1 
ATOM   3596 N  N   . PHE B 1 176 ? -29.188 -28.511 41.907  1.00 34.81 ? 181 PHE B N   1 
ATOM   3597 C  CA  . PHE B 1 176 ? -27.970 -28.325 41.130  1.00 35.19 ? 181 PHE B CA  1 
ATOM   3598 C  C   . PHE B 1 176 ? -26.826 -29.238 41.565  1.00 35.73 ? 181 PHE B C   1 
ATOM   3599 O  O   . PHE B 1 176 ? -25.727 -29.133 41.024  1.00 34.72 ? 181 PHE B O   1 
ATOM   3600 C  CB  . PHE B 1 176 ? -27.501 -26.862 41.217  1.00 34.86 ? 181 PHE B CB  1 
ATOM   3601 C  CG  . PHE B 1 176 ? -28.353 -25.900 40.433  1.00 36.03 ? 181 PHE B CG  1 
ATOM   3602 C  CD1 . PHE B 1 176 ? -29.640 -25.575 40.854  1.00 35.08 ? 181 PHE B CD1 1 
ATOM   3603 C  CD2 . PHE B 1 176 ? -27.866 -25.321 39.259  1.00 36.85 ? 181 PHE B CD2 1 
ATOM   3604 C  CE1 . PHE B 1 176 ? -30.428 -24.694 40.130  1.00 35.71 ? 181 PHE B CE1 1 
ATOM   3605 C  CE2 . PHE B 1 176 ? -28.648 -24.433 38.529  1.00 35.96 ? 181 PHE B CE2 1 
ATOM   3606 C  CZ  . PHE B 1 176 ? -29.934 -24.120 38.965  1.00 35.61 ? 181 PHE B CZ  1 
ATOM   3607 N  N   . SER B 1 177 ? -27.079 -30.111 42.552  1.00 35.85 ? 182 SER B N   1 
ATOM   3608 C  CA  . SER B 1 177 ? -26.050 -31.014 43.091  1.00 36.70 ? 182 SER B CA  1 
ATOM   3609 C  C   . SER B 1 177 ? -25.589 -32.037 42.054  1.00 36.41 ? 182 SER B C   1 
ATOM   3610 O  O   . SER B 1 177 ? -24.445 -32.459 42.081  1.00 36.35 ? 182 SER B O   1 
ATOM   3611 C  CB  . SER B 1 177 ? -26.598 -31.786 44.295  1.00 36.52 ? 182 SER B CB  1 
ATOM   3612 O  OG  . SER B 1 177 ? -27.774 -32.473 43.882  1.00 37.82 ? 182 SER B OG  1 
ATOM   3613 N  N   . TRP B 1 178 ? -26.500 -32.440 41.170  1.00 36.58 ? 183 TRP B N   1 
ATOM   3614 C  CA  . TRP B 1 178 ? -26.204 -33.398 40.091  1.00 36.68 ? 183 TRP B CA  1 
ATOM   3615 C  C   . TRP B 1 178 ? -25.065 -32.960 39.157  1.00 36.95 ? 183 TRP B C   1 
ATOM   3616 O  O   . TRP B 1 178 ? -24.432 -33.801 38.509  1.00 36.94 ? 183 TRP B O   1 
ATOM   3617 C  CB  . TRP B 1 178 ? -27.469 -33.682 39.265  1.00 36.30 ? 183 TRP B CB  1 
ATOM   3618 C  CG  . TRP B 1 178 ? -27.999 -32.496 38.472  1.00 35.78 ? 183 TRP B CG  1 
ATOM   3619 C  CD1 . TRP B 1 178 ? -28.882 -31.535 38.909  1.00 35.49 ? 183 TRP B CD1 1 
ATOM   3620 C  CD2 . TRP B 1 178 ? -27.700 -32.168 37.102  1.00 34.44 ? 183 TRP B CD2 1 
ATOM   3621 N  NE1 . TRP B 1 178 ? -29.144 -30.628 37.891  1.00 34.64 ? 183 TRP B NE1 1 
ATOM   3622 C  CE2 . TRP B 1 178 ? -28.431 -30.995 36.777  1.00 33.73 ? 183 TRP B CE2 1 
ATOM   3623 C  CE3 . TRP B 1 178 ? -26.886 -32.752 36.116  1.00 32.92 ? 183 TRP B CE3 1 
ATOM   3624 C  CZ2 . TRP B 1 178 ? -28.355 -30.385 35.506  1.00 32.95 ? 183 TRP B CZ2 1 
ATOM   3625 C  CZ3 . TRP B 1 178 ? -26.817 -32.148 34.849  1.00 30.78 ? 183 TRP B CZ3 1 
ATOM   3626 C  CH2 . TRP B 1 178 ? -27.547 -30.980 34.558  1.00 30.56 ? 183 TRP B CH2 1 
ATOM   3627 N  N   . ILE B 1 179 ? -24.810 -31.649 39.099  1.00 37.26 ? 184 ILE B N   1 
ATOM   3628 C  CA  . ILE B 1 179 ? -23.895 -31.065 38.117  1.00 37.41 ? 184 ILE B CA  1 
ATOM   3629 C  C   . ILE B 1 179 ? -22.434 -31.218 38.507  1.00 37.73 ? 184 ILE B C   1 
ATOM   3630 O  O   . ILE B 1 179 ? -21.941 -30.506 39.377  1.00 38.83 ? 184 ILE B O   1 
ATOM   3631 C  CB  . ILE B 1 179 ? -24.151 -29.550 37.904  1.00 37.09 ? 184 ILE B CB  1 
ATOM   3632 C  CG1 . ILE B 1 179 ? -25.618 -29.269 37.600  1.00 36.09 ? 184 ILE B CG1 1 
ATOM   3633 C  CG2 . ILE B 1 179 ? -23.257 -28.998 36.768  1.00 37.20 ? 184 ILE B CG2 1 
ATOM   3634 C  CD1 . ILE B 1 179 ? -25.970 -27.801 37.660  1.00 35.38 ? 184 ILE B CD1 1 
ATOM   3635 N  N   . LYS B 1 180 ? -21.733 -32.105 37.821  1.00 38.04 ? 185 LYS B N   1 
ATOM   3636 C  CA  . LYS B 1 180 ? -20.302 -32.257 38.018  1.00 38.58 ? 185 LYS B CA  1 
ATOM   3637 C  C   . LYS B 1 180 ? -19.627 -31.270 37.064  1.00 37.85 ? 185 LYS B C   1 
ATOM   3638 O  O   . LYS B 1 180 ? -19.873 -31.334 35.856  1.00 38.41 ? 185 LYS B O   1 
ATOM   3639 C  CB  . LYS B 1 180 ? -19.863 -33.693 37.682  1.00 39.06 ? 185 LYS B CB  1 
ATOM   3640 C  CG  . LYS B 1 180 ? -20.485 -34.803 38.552  1.00 42.61 ? 185 LYS B CG  1 
ATOM   3641 C  CD  . LYS B 1 180 ? -20.226 -36.198 37.948  1.00 46.13 ? 185 LYS B CD  1 
ATOM   3642 C  CE  . LYS B 1 180 ? -20.602 -37.329 38.907  1.00 48.59 ? 185 LYS B CE  1 
ATOM   3643 N  NZ  . LYS B 1 180 ? -22.069 -37.435 39.150  1.00 49.77 ? 185 LYS B NZ  1 
ATOM   3644 N  N   . PRO B 1 181 ? -18.806 -30.339 37.587  1.00 37.32 ? 186 PRO B N   1 
ATOM   3645 C  CA  . PRO B 1 181 ? -18.052 -29.449 36.693  1.00 36.98 ? 186 PRO B CA  1 
ATOM   3646 C  C   . PRO B 1 181 ? -17.276 -30.243 35.641  1.00 36.85 ? 186 PRO B C   1 
ATOM   3647 O  O   . PRO B 1 181 ? -16.501 -31.150 35.990  1.00 36.96 ? 186 PRO B O   1 
ATOM   3648 C  CB  . PRO B 1 181 ? -17.092 -28.715 37.641  1.00 36.87 ? 186 PRO B CB  1 
ATOM   3649 C  CG  . PRO B 1 181 ? -17.316 -29.314 38.999  1.00 36.80 ? 186 PRO B CG  1 
ATOM   3650 C  CD  . PRO B 1 181 ? -18.675 -29.909 38.988  1.00 37.26 ? 186 PRO B CD  1 
ATOM   3651 N  N   . CYS B 1 182 ? -17.484 -29.905 34.369  1.00 36.26 ? 187 CYS B N   1 
ATOM   3652 C  CA  . CYS B 1 182 ? -16.945 -30.718 33.275  1.00 36.17 ? 187 CYS B CA  1 
ATOM   3653 C  C   . CYS B 1 182 ? -16.041 -29.990 32.292  1.00 35.90 ? 187 CYS B C   1 
ATOM   3654 O  O   . CYS B 1 182 ? -15.466 -30.621 31.416  1.00 36.64 ? 187 CYS B O   1 
ATOM   3655 C  CB  . CYS B 1 182 ? -18.080 -31.427 32.525  1.00 35.92 ? 187 CYS B CB  1 
ATOM   3656 S  SG  . CYS B 1 182 ? -19.344 -30.322 31.815  1.00 37.64 ? 187 CYS B SG  1 
ATOM   3657 N  N   . ILE B 1 183 ? -15.900 -28.675 32.397  1.00 35.03 ? 188 ILE B N   1 
ATOM   3658 C  CA  . ILE B 1 183 ? -14.949 -28.015 31.494  1.00 34.77 ? 188 ILE B CA  1 
ATOM   3659 C  C   . ILE B 1 183 ? -13.930 -27.237 32.259  1.00 33.63 ? 188 ILE B C   1 
ATOM   3660 O  O   . ILE B 1 183 ? -14.254 -26.636 33.284  1.00 34.56 ? 188 ILE B O   1 
ATOM   3661 C  CB  . ILE B 1 183 ? -15.618 -27.160 30.369  1.00 34.41 ? 188 ILE B CB  1 
ATOM   3662 C  CG1 . ILE B 1 183 ? -16.653 -26.203 30.941  1.00 35.27 ? 188 ILE B CG1 1 
ATOM   3663 C  CG2 . ILE B 1 183 ? -16.260 -28.076 29.324  1.00 36.16 ? 188 ILE B CG2 1 
ATOM   3664 C  CD1 . ILE B 1 183 ? -17.005 -25.027 30.005  1.00 39.02 ? 188 ILE B CD1 1 
ATOM   3665 N  N   . SER B 1 184 ? -12.691 -27.285 31.785  1.00 33.03 ? 189 SER B N   1 
ATOM   3666 C  CA  . SER B 1 184 ? -11.634 -26.443 32.313  1.00 32.17 ? 189 SER B CA  1 
ATOM   3667 C  C   . SER B 1 184 ? -11.640 -25.094 31.609  1.00 31.50 ? 189 SER B C   1 
ATOM   3668 O  O   . SER B 1 184 ? -12.166 -24.951 30.496  1.00 30.00 ? 189 SER B O   1 
ATOM   3669 C  CB  . SER B 1 184 ? -10.264 -27.087 32.119  1.00 32.60 ? 189 SER B CB  1 
ATOM   3670 O  OG  . SER B 1 184 ? -9.902  -27.124 30.729  1.00 36.11 ? 189 SER B OG  1 
ATOM   3671 N  N   . SER B 1 185 ? -11.000 -24.125 32.254  1.00 30.62 ? 190 SER B N   1 
ATOM   3672 C  CA  . SER B 1 185 ? -10.907 -22.773 31.755  1.00 29.79 ? 190 SER B CA  1 
ATOM   3673 C  C   . SER B 1 185 ? -10.214 -22.705 30.381  1.00 28.76 ? 190 SER B C   1 
ATOM   3674 O  O   . SER B 1 185 ? -10.471 -21.781 29.594  1.00 27.94 ? 190 SER B O   1 
ATOM   3675 C  CB  . SER B 1 185 ? -10.182 -21.906 32.781  1.00 29.99 ? 190 SER B CB  1 
ATOM   3676 O  OG  . SER B 1 185 ? -8.827  -22.295 32.870  1.00 33.09 ? 190 SER B OG  1 
ATOM   3677 N  N   . ALA B 1 186 ? -9.360  -23.683 30.081  1.00 27.10 ? 191 ALA B N   1 
ATOM   3678 C  CA  . ALA B 1 186 ? -8.637  -23.642 28.805  1.00 26.12 ? 191 ALA B CA  1 
ATOM   3679 C  C   . ALA B 1 186 ? -9.418  -24.245 27.638  1.00 24.26 ? 191 ALA B C   1 
ATOM   3680 O  O   . ALA B 1 186 ? -8.921  -24.252 26.511  1.00 24.70 ? 191 ALA B O   1 
ATOM   3681 C  CB  . ALA B 1 186 ? -7.200  -24.280 28.932  1.00 26.49 ? 191 ALA B CB  1 
ATOM   3682 N  N   . SER B 1 187 ? -10.625 -24.736 27.898  1.00 22.60 ? 192 SER B N   1 
ATOM   3683 C  CA  . SER B 1 187 ? -11.414 -25.445 26.908  1.00 22.56 ? 192 SER B CA  1 
ATOM   3684 C  C   . SER B 1 187 ? -12.690 -24.727 26.545  1.00 21.79 ? 192 SER B C   1 
ATOM   3685 O  O   . SER B 1 187 ? -13.588 -25.328 25.970  1.00 21.53 ? 192 SER B O   1 
ATOM   3686 C  CB  . SER B 1 187 ? -11.757 -26.864 27.394  1.00 23.79 ? 192 SER B CB  1 
ATOM   3687 O  OG  . SER B 1 187 ? -10.570 -27.640 27.476  1.00 25.06 ? 192 SER B OG  1 
ATOM   3688 N  N   . ILE B 1 188 ? -12.782 -23.448 26.907  1.00 20.77 ? 193 ILE B N   1 
ATOM   3689 C  CA  . ILE B 1 188 ? -13.900 -22.628 26.443  1.00 19.77 ? 193 ILE B CA  1 
ATOM   3690 C  C   . ILE B 1 188 ? -13.314 -21.324 25.895  1.00 18.83 ? 193 ILE B C   1 
ATOM   3691 O  O   . ILE B 1 188 ? -12.392 -20.754 26.471  1.00 19.14 ? 193 ILE B O   1 
ATOM   3692 C  CB  . ILE B 1 188 ? -14.991 -22.381 27.549  1.00 20.14 ? 193 ILE B CB  1 
ATOM   3693 C  CG1 . ILE B 1 188 ? -16.119 -21.488 26.992  1.00 19.84 ? 193 ILE B CG1 1 
ATOM   3694 C  CG2 . ILE B 1 188 ? -14.342 -21.783 28.795  1.00 19.91 ? 193 ILE B CG2 1 
ATOM   3695 C  CD1 . ILE B 1 188 ? -17.357 -21.286 27.885  1.00 18.38 ? 193 ILE B CD1 1 
ATOM   3696 N  N   . VAL B 1 189 ? -13.824 -20.891 24.747  1.00 17.69 ? 194 VAL B N   1 
ATOM   3697 C  CA  . VAL B 1 189 ? -13.467 -19.594 24.183  1.00 16.20 ? 194 VAL B CA  1 
ATOM   3698 C  C   . VAL B 1 189 ? -14.760 -18.855 23.874  1.00 16.31 ? 194 VAL B C   1 
ATOM   3699 O  O   . VAL B 1 189 ? -15.688 -19.433 23.305  1.00 15.41 ? 194 VAL B O   1 
ATOM   3700 C  CB  . VAL B 1 189 ? -12.624 -19.739 22.919  1.00 17.34 ? 194 VAL B CB  1 
ATOM   3701 C  CG1 . VAL B 1 189 ? -12.473 -18.366 22.180  1.00 18.40 ? 194 VAL B CG1 1 
ATOM   3702 C  CG2 . VAL B 1 189 ? -11.225 -20.225 23.286  1.00 15.84 ? 194 VAL B CG2 1 
ATOM   3703 N  N   . TYR B 1 190 ? -14.815 -17.583 24.278  1.00 15.98 ? 195 TYR B N   1 
ATOM   3704 C  CA  . TYR B 1 190 ? -15.936 -16.715 23.967  1.00 15.86 ? 195 TYR B CA  1 
ATOM   3705 C  C   . TYR B 1 190 ? -15.669 -15.884 22.712  1.00 14.20 ? 195 TYR B C   1 
ATOM   3706 O  O   . TYR B 1 190 ? -14.548 -15.459 22.456  1.00 14.54 ? 195 TYR B O   1 
ATOM   3707 C  CB  . TYR B 1 190 ? -16.203 -15.694 25.094  1.00 16.58 ? 195 TYR B CB  1 
ATOM   3708 C  CG  . TYR B 1 190 ? -16.696 -16.280 26.390  1.00 16.02 ? 195 TYR B CG  1 
ATOM   3709 C  CD1 . TYR B 1 190 ? -18.064 -16.429 26.631  1.00 17.02 ? 195 TYR B CD1 1 
ATOM   3710 C  CD2 . TYR B 1 190 ? -15.791 -16.680 27.371  1.00 19.50 ? 195 TYR B CD2 1 
ATOM   3711 C  CE1 . TYR B 1 190 ? -18.528 -16.988 27.831  1.00 17.14 ? 195 TYR B CE1 1 
ATOM   3712 C  CE2 . TYR B 1 190 ? -16.241 -17.224 28.597  1.00 19.59 ? 195 TYR B CE2 1 
ATOM   3713 C  CZ  . TYR B 1 190 ? -17.614 -17.360 28.803  1.00 19.24 ? 195 TYR B CZ  1 
ATOM   3714 O  OH  . TYR B 1 190 ? -18.076 -17.862 29.996  1.00 20.71 ? 195 TYR B OH  1 
ATOM   3715 N  N   . ILE B 1 191 ? -16.742 -15.630 21.977  1.00 13.11 ? 196 ILE B N   1 
ATOM   3716 C  CA  . ILE B 1 191 ? -16.691 -14.757 20.810  1.00 12.66 ? 196 ILE B CA  1 
ATOM   3717 C  C   . ILE B 1 191 ? -17.894 -13.841 20.843  1.00 12.48 ? 196 ILE B C   1 
ATOM   3718 O  O   . ILE B 1 191 ? -19.012 -14.331 20.926  1.00 12.74 ? 196 ILE B O   1 
ATOM   3719 C  CB  . ILE B 1 191 ? -16.720 -15.575 19.477  1.00 11.75 ? 196 ILE B CB  1 
ATOM   3720 C  CG1 . ILE B 1 191 ? -15.478 -16.485 19.362  1.00 14.19 ? 196 ILE B CG1 1 
ATOM   3721 C  CG2 . ILE B 1 191 ? -16.734 -14.560 18.293  1.00 12.71 ? 196 ILE B CG2 1 
ATOM   3722 C  CD1 . ILE B 1 191 ? -15.472 -17.409 18.103  1.00 15.85 ? 196 ILE B CD1 1 
ATOM   3723 N  N   . GLY B 1 192 ? -17.673 -12.526 20.755  1.00 12.92 ? 197 GLY B N   1 
ATOM   3724 C  CA  . GLY B 1 192 ? -18.795 -11.598 20.585  1.00 13.79 ? 197 GLY B CA  1 
ATOM   3725 C  C   . GLY B 1 192 ? -19.065 -10.688 21.766  1.00 14.51 ? 197 GLY B C   1 
ATOM   3726 O  O   . GLY B 1 192 ? -19.985 -9.857  21.699  1.00 15.97 ? 197 GLY B O   1 
ATOM   3727 N  N   . LEU B 1 193 ? -18.303 -10.870 22.843  1.00 14.02 ? 198 LEU B N   1 
ATOM   3728 C  CA  . LEU B 1 193 ? -18.529 -10.190 24.128  1.00 14.63 ? 198 LEU B CA  1 
ATOM   3729 C  C   . LEU B 1 193 ? -18.556 -8.669  24.030  1.00 15.26 ? 198 LEU B C   1 
ATOM   3730 O  O   . LEU B 1 193 ? -17.658 -8.038  23.472  1.00 14.37 ? 198 LEU B O   1 
ATOM   3731 C  CB  . LEU B 1 193 ? -17.441 -10.578 25.141  1.00 14.52 ? 198 LEU B CB  1 
ATOM   3732 C  CG  . LEU B 1 193 ? -17.275 -12.050 25.547  1.00 14.40 ? 198 LEU B CG  1 
ATOM   3733 C  CD1 . LEU B 1 193 ? -16.361 -12.137 26.738  1.00 13.06 ? 198 LEU B CD1 1 
ATOM   3734 C  CD2 . LEU B 1 193 ? -18.662 -12.619 25.863  1.00 12.08 ? 198 LEU B CD2 1 
ATOM   3735 N  N   . ARG B 1 194 ? -19.584 -8.090  24.635  1.00 16.43 ? 199 ARG B N   1 
ATOM   3736 C  CA  . ARG B 1 194 ? -19.708 -6.647  24.678  1.00 17.20 ? 199 ARG B CA  1 
ATOM   3737 C  C   . ARG B 1 194 ? -20.450 -6.107  25.901  1.00 18.78 ? 199 ARG B C   1 
ATOM   3738 O  O   . ARG B 1 194 ? -20.558 -4.901  26.031  1.00 19.76 ? 199 ARG B O   1 
ATOM   3739 C  CB  . ARG B 1 194 ? -20.324 -6.117  23.370  1.00 16.10 ? 199 ARG B CB  1 
ATOM   3740 C  CG  . ARG B 1 194 ? -21.731 -6.579  23.062  1.00 16.57 ? 199 ARG B CG  1 
ATOM   3741 C  CD  . ARG B 1 194 ? -22.038 -6.168  21.630  1.00 14.56 ? 199 ARG B CD  1 
ATOM   3742 N  NE  . ARG B 1 194 ? -23.372 -6.553  21.169  1.00 14.51 ? 199 ARG B NE  1 
ATOM   3743 C  CZ  . ARG B 1 194 ? -23.686 -7.745  20.670  1.00 14.67 ? 199 ARG B CZ  1 
ATOM   3744 N  NH1 . ARG B 1 194 ? -22.765 -8.702  20.572  1.00 14.24 ? 199 ARG B NH1 1 
ATOM   3745 N  NH2 . ARG B 1 194 ? -24.918 -7.963  20.220  1.00 12.27 ? 199 ARG B NH2 1 
ATOM   3746 N  N   . ASP B 1 195 ? -20.949 -6.980  26.771  1.00 19.22 ? 200 ASP B N   1 
ATOM   3747 C  CA  . ASP B 1 195 ? -21.722 -6.573  27.965  1.00 20.99 ? 200 ASP B CA  1 
ATOM   3748 C  C   . ASP B 1 195 ? -21.339 -7.523  29.103  1.00 21.08 ? 200 ASP B C   1 
ATOM   3749 O  O   . ASP B 1 195 ? -22.056 -8.493  29.411  1.00 21.77 ? 200 ASP B O   1 
ATOM   3750 C  CB  . ASP B 1 195 ? -23.230 -6.599  27.673  1.00 21.30 ? 200 ASP B CB  1 
ATOM   3751 C  CG  . ASP B 1 195 ? -24.096 -6.181  28.885  1.00 25.92 ? 200 ASP B CG  1 
ATOM   3752 O  OD1 . ASP B 1 195 ? -23.602 -5.419  29.731  1.00 27.71 ? 200 ASP B OD1 1 
ATOM   3753 O  OD2 . ASP B 1 195 ? -25.273 -6.632  28.980  1.00 29.51 ? 200 ASP B OD2 1 
ATOM   3754 N  N   . VAL B 1 196 ? -20.182 -7.247  29.699  1.00 20.73 ? 201 VAL B N   1 
ATOM   3755 C  CA  . VAL B 1 196 ? -19.560 -8.122  30.685  1.00 20.84 ? 201 VAL B CA  1 
ATOM   3756 C  C   . VAL B 1 196 ? -19.518 -7.381  32.051  1.00 22.23 ? 201 VAL B C   1 
ATOM   3757 O  O   . VAL B 1 196 ? -18.936 -6.293  32.138  1.00 22.24 ? 201 VAL B O   1 
ATOM   3758 C  CB  . VAL B 1 196 ? -18.100 -8.477  30.289  1.00 20.87 ? 201 VAL B CB  1 
ATOM   3759 C  CG1 . VAL B 1 196 ? -17.538 -9.550  31.223  1.00 20.25 ? 201 VAL B CG1 1 
ATOM   3760 C  CG2 . VAL B 1 196 ? -17.978 -8.999  28.828  1.00 19.88 ? 201 VAL B CG2 1 
ATOM   3761 N  N   . ASP B 1 197 ? -20.129 -7.974  33.088  1.00 22.90 ? 202 ASP B N   1 
ATOM   3762 C  CA  . ASP B 1 197 ? -20.161 -7.381  34.453  1.00 23.88 ? 202 ASP B CA  1 
ATOM   3763 C  C   . ASP B 1 197 ? -18.772 -7.382  35.059  1.00 23.70 ? 202 ASP B C   1 
ATOM   3764 O  O   . ASP B 1 197 ? -17.980 -8.250  34.750  1.00 23.90 ? 202 ASP B O   1 
ATOM   3765 C  CB  . ASP B 1 197 ? -21.044 -8.196  35.402  1.00 23.75 ? 202 ASP B CB  1 
ATOM   3766 C  CG  . ASP B 1 197 ? -22.486 -8.200  34.996  1.00 25.75 ? 202 ASP B CG  1 
ATOM   3767 O  OD1 . ASP B 1 197 ? -22.946 -7.292  34.247  1.00 27.97 ? 202 ASP B OD1 1 
ATOM   3768 O  OD2 . ASP B 1 197 ? -23.179 -9.133  35.429  1.00 27.84 ? 202 ASP B OD2 1 
ATOM   3769 N  N   . PRO B 1 198 ? -18.487 -6.442  35.982  1.00 23.73 ? 203 PRO B N   1 
ATOM   3770 C  CA  . PRO B 1 198 ? -17.165 -6.433  36.613  1.00 23.73 ? 203 PRO B CA  1 
ATOM   3771 C  C   . PRO B 1 198 ? -16.687 -7.776  37.243  1.00 23.24 ? 203 PRO B C   1 
ATOM   3772 O  O   . PRO B 1 198 ? -15.537 -8.153  37.028  1.00 23.59 ? 203 PRO B O   1 
ATOM   3773 C  CB  . PRO B 1 198 ? -17.273 -5.296  37.655  1.00 23.94 ? 203 PRO B CB  1 
ATOM   3774 C  CG  . PRO B 1 198 ? -18.301 -4.394  37.089  1.00 23.67 ? 203 PRO B CG  1 
ATOM   3775 C  CD  . PRO B 1 198 ? -19.318 -5.305  36.418  1.00 24.18 ? 203 PRO B CD  1 
ATOM   3776 N  N   . PRO B 1 199 ? -17.555 -8.507  37.981  1.00 23.66 ? 204 PRO B N   1 
ATOM   3777 C  CA  . PRO B 1 199 ? -17.088 -9.808  38.481  1.00 23.08 ? 204 PRO B CA  1 
ATOM   3778 C  C   . PRO B 1 199 ? -16.750 -10.824 37.374  1.00 23.12 ? 204 PRO B C   1 
ATOM   3779 O  O   . PRO B 1 199 ? -15.833 -11.645 37.534  1.00 22.68 ? 204 PRO B O   1 
ATOM   3780 C  CB  . PRO B 1 199 ? -18.273 -10.310 39.323  1.00 23.19 ? 204 PRO B CB  1 
ATOM   3781 C  CG  . PRO B 1 199 ? -19.453 -9.556  38.853  1.00 24.34 ? 204 PRO B CG  1 
ATOM   3782 C  CD  . PRO B 1 199 ? -18.911 -8.199  38.488  1.00 23.57 ? 204 PRO B CD  1 
ATOM   3783 N  N   . GLU B 1 200 ? -17.470 -10.727 36.260  1.00 22.64 ? 205 GLU B N   1 
ATOM   3784 C  CA  . GLU B 1 200 ? -17.249 -11.562 35.083  1.00 22.85 ? 205 GLU B CA  1 
ATOM   3785 C  C   . GLU B 1 200 ? -15.888 -11.265 34.483  1.00 23.33 ? 205 GLU B C   1 
ATOM   3786 O  O   . GLU B 1 200 ? -15.123 -12.192 34.169  1.00 22.92 ? 205 GLU B O   1 
ATOM   3787 C  CB  . GLU B 1 200 ? -18.365 -11.312 34.068  1.00 22.32 ? 205 GLU B CB  1 
ATOM   3788 C  CG  . GLU B 1 200 ? -19.680 -11.935 34.514  1.00 22.56 ? 205 GLU B CG  1 
ATOM   3789 C  CD  . GLU B 1 200 ? -20.803 -11.835 33.494  1.00 23.26 ? 205 GLU B CD  1 
ATOM   3790 O  OE1 . GLU B 1 200 ? -21.192 -10.691 33.127  1.00 23.46 ? 205 GLU B OE1 1 
ATOM   3791 O  OE2 . GLU B 1 200 ? -21.314 -12.904 33.074  1.00 20.47 ? 205 GLU B OE2 1 
ATOM   3792 N  N   . HIS B 1 201 ? -15.576 -9.972  34.368  1.00 23.68 ? 206 HIS B N   1 
ATOM   3793 C  CA  . HIS B 1 201 ? -14.311 -9.556  33.793  1.00 24.05 ? 206 HIS B CA  1 
ATOM   3794 C  C   . HIS B 1 201 ? -13.178 -10.024 34.695  1.00 24.69 ? 206 HIS B C   1 
ATOM   3795 O  O   . HIS B 1 201 ? -12.151 -10.511 34.212  1.00 25.31 ? 206 HIS B O   1 
ATOM   3796 C  CB  . HIS B 1 201 ? -14.251 -8.049  33.526  1.00 23.86 ? 206 HIS B CB  1 
ATOM   3797 C  CG  . HIS B 1 201 ? -12.915 -7.594  33.019  1.00 24.71 ? 206 HIS B CG  1 
ATOM   3798 N  ND1 . HIS B 1 201 ? -12.635 -7.456  31.673  1.00 27.29 ? 206 HIS B ND1 1 
ATOM   3799 C  CD2 . HIS B 1 201 ? -11.774 -7.283  33.673  1.00 23.81 ? 206 HIS B CD2 1 
ATOM   3800 C  CE1 . HIS B 1 201 ? -11.375 -7.077  31.527  1.00 26.15 ? 206 HIS B CE1 1 
ATOM   3801 N  NE2 . HIS B 1 201 ? -10.827 -6.988  32.723  1.00 24.86 ? 206 HIS B NE2 1 
ATOM   3802 N  N   . PHE B 1 202 ? -13.388 -9.915  36.008  1.00 25.11 ? 207 PHE B N   1 
ATOM   3803 C  CA  . PHE B 1 202 ? -12.468 -10.482 36.987  1.00 25.49 ? 207 PHE B CA  1 
ATOM   3804 C  C   . PHE B 1 202 ? -12.208 -11.967 36.756  1.00 24.79 ? 207 PHE B C   1 
ATOM   3805 O  O   . PHE B 1 202 ? -11.062 -12.391 36.743  1.00 25.68 ? 207 PHE B O   1 
ATOM   3806 C  CB  . PHE B 1 202 ? -13.002 -10.286 38.420  1.00 26.05 ? 207 PHE B CB  1 
ATOM   3807 C  CG  . PHE B 1 202 ? -12.158 -10.958 39.469  1.00 27.40 ? 207 PHE B CG  1 
ATOM   3808 C  CD1 . PHE B 1 202 ? -11.061 -10.293 40.015  1.00 29.19 ? 207 PHE B CD1 1 
ATOM   3809 C  CD2 . PHE B 1 202 ? -12.464 -12.239 39.920  1.00 28.25 ? 207 PHE B CD2 1 
ATOM   3810 C  CE1 . PHE B 1 202 ? -10.266 -10.902 41.001  1.00 31.39 ? 207 PHE B CE1 1 
ATOM   3811 C  CE2 . PHE B 1 202 ? -11.672 -12.865 40.902  1.00 31.74 ? 207 PHE B CE2 1 
ATOM   3812 C  CZ  . PHE B 1 202 ? -10.566 -12.191 41.437  1.00 31.14 ? 207 PHE B CZ  1 
ATOM   3813 N  N   . ILE B 1 203 ? -13.278 -12.742 36.612  1.00 24.77 ? 208 ILE B N   1 
ATOM   3814 C  CA  . ILE B 1 203 ? -13.195 -14.185 36.371  1.00 25.09 ? 208 ILE B CA  1 
ATOM   3815 C  C   . ILE B 1 203 ? -12.450 -14.508 35.087  1.00 25.23 ? 208 ILE B C   1 
ATOM   3816 O  O   . ILE B 1 203 ? -11.524 -15.333 35.093  1.00 26.19 ? 208 ILE B O   1 
ATOM   3817 C  CB  . ILE B 1 203 ? -14.596 -14.840 36.360  1.00 25.11 ? 208 ILE B CB  1 
ATOM   3818 C  CG1 . ILE B 1 203 ? -15.187 -14.826 37.780  1.00 25.27 ? 208 ILE B CG1 1 
ATOM   3819 C  CG2 . ILE B 1 203 ? -14.536 -16.258 35.766  1.00 24.80 ? 208 ILE B CG2 1 
ATOM   3820 C  CD1 . ILE B 1 203 ? -16.713 -15.073 37.844  1.00 25.26 ? 208 ILE B CD1 1 
ATOM   3821 N  N   . LEU B 1 204 ? -12.866 -13.878 33.987  1.00 24.78 ? 209 LEU B N   1 
ATOM   3822 C  CA  . LEU B 1 204 ? -12.209 -14.061 32.698  1.00 25.11 ? 209 LEU B CA  1 
ATOM   3823 C  C   . LEU B 1 204 ? -10.719 -13.881 32.836  1.00 25.73 ? 209 LEU B C   1 
ATOM   3824 O  O   . LEU B 1 204 ? -9.974  -14.777 32.451  1.00 26.42 ? 209 LEU B O   1 
ATOM   3825 C  CB  . LEU B 1 204 ? -12.783 -13.132 31.611  1.00 24.25 ? 209 LEU B CB  1 
ATOM   3826 C  CG  . LEU B 1 204 ? -14.243 -13.450 31.246  1.00 24.03 ? 209 LEU B CG  1 
ATOM   3827 C  CD1 . LEU B 1 204 ? -14.759 -12.480 30.229  1.00 22.32 ? 209 LEU B CD1 1 
ATOM   3828 C  CD2 . LEU B 1 204 ? -14.397 -14.896 30.738  1.00 24.91 ? 209 LEU B CD2 1 
ATOM   3829 N  N   . LYS B 1 205 ? -10.289 -12.762 33.425  1.00 26.69 ? 210 LYS B N   1 
ATOM   3830 C  CA  . LYS B 1 205 ? -8.841  -12.443 33.502  1.00 28.13 ? 210 LYS B CA  1 
ATOM   3831 C  C   . LYS B 1 205 ? -8.084  -13.332 34.481  1.00 28.69 ? 210 LYS B C   1 
ATOM   3832 O  O   . LYS B 1 205 ? -6.961  -13.777 34.198  1.00 29.03 ? 210 LYS B O   1 
ATOM   3833 C  CB  . LYS B 1 205 ? -8.593  -10.985 33.875  1.00 27.11 ? 210 LYS B CB  1 
ATOM   3834 C  CG  . LYS B 1 205 ? -8.982  -9.995  32.811  1.00 29.71 ? 210 LYS B CG  1 
ATOM   3835 C  CD  . LYS B 1 205 ? -8.095  -10.098 31.546  1.00 32.51 ? 210 LYS B CD  1 
ATOM   3836 C  CE  . LYS B 1 205 ? -8.560  -9.093  30.509  1.00 32.90 ? 210 LYS B CE  1 
ATOM   3837 N  NZ  . LYS B 1 205 ? -7.644  -8.983  29.321  1.00 36.26 ? 210 LYS B NZ  1 
ATOM   3838 N  N   . ASN B 1 206 ? -8.703  -13.608 35.621  1.00 29.70 ? 211 ASN B N   1 
ATOM   3839 C  CA  . ASN B 1 206 ? -7.993  -14.332 36.675  1.00 30.44 ? 211 ASN B CA  1 
ATOM   3840 C  C   . ASN B 1 206 ? -7.939  -15.827 36.464  1.00 30.26 ? 211 ASN B C   1 
ATOM   3841 O  O   . ASN B 1 206 ? -7.017  -16.488 36.918  1.00 30.71 ? 211 ASN B O   1 
ATOM   3842 C  CB  . ASN B 1 206 ? -8.530  -13.965 38.055  1.00 30.99 ? 211 ASN B CB  1 
ATOM   3843 C  CG  . ASN B 1 206 ? -7.627  -12.983 38.760  1.00 33.55 ? 211 ASN B CG  1 
ATOM   3844 O  OD1 . ASN B 1 206 ? -6.756  -13.393 39.528  1.00 36.97 ? 211 ASN B OD1 1 
ATOM   3845 N  ND2 . ASN B 1 206 ? -7.787  -11.677 38.465  1.00 35.26 ? 211 ASN B ND2 1 
ATOM   3846 N  N   . TYR B 1 207 ? -8.926  -16.370 35.762  1.00 29.85 ? 212 TYR B N   1 
ATOM   3847 C  CA  . TYR B 1 207 ? -8.879  -17.779 35.406  1.00 28.32 ? 212 TYR B CA  1 
ATOM   3848 C  C   . TYR B 1 207 ? -8.272  -18.048 33.996  1.00 27.94 ? 212 TYR B C   1 
ATOM   3849 O  O   . TYR B 1 207 ? -8.271  -19.176 33.520  1.00 26.99 ? 212 TYR B O   1 
ATOM   3850 C  CB  . TYR B 1 207 ? -10.256 -18.397 35.625  1.00 28.74 ? 212 TYR B CB  1 
ATOM   3851 C  CG  . TYR B 1 207 ? -10.660 -18.402 37.100  1.00 29.39 ? 212 TYR B CG  1 
ATOM   3852 C  CD1 . TYR B 1 207 ? -11.212 -17.263 37.719  1.00 30.42 ? 212 TYR B CD1 1 
ATOM   3853 C  CD2 . TYR B 1 207 ? -10.463 -19.539 37.887  1.00 31.88 ? 212 TYR B CD2 1 
ATOM   3854 C  CE1 . TYR B 1 207 ? -11.570 -17.275 39.095  1.00 32.61 ? 212 TYR B CE1 1 
ATOM   3855 C  CE2 . TYR B 1 207 ? -10.824 -19.561 39.253  1.00 31.94 ? 212 TYR B CE2 1 
ATOM   3856 C  CZ  . TYR B 1 207 ? -11.371 -18.432 39.844  1.00 33.19 ? 212 TYR B CZ  1 
ATOM   3857 O  OH  . TYR B 1 207 ? -11.725 -18.485 41.179  1.00 33.01 ? 212 TYR B OH  1 
ATOM   3858 N  N   . ASP B 1 208 ? -7.729  -17.005 33.366  1.00 27.31 ? 213 ASP B N   1 
ATOM   3859 C  CA  . ASP B 1 208 ? -7.101  -17.099 32.035  1.00 27.81 ? 213 ASP B CA  1 
ATOM   3860 C  C   . ASP B 1 208 ? -8.040  -17.632 30.966  1.00 26.15 ? 213 ASP B C   1 
ATOM   3861 O  O   . ASP B 1 208 ? -7.617  -18.424 30.133  1.00 26.75 ? 213 ASP B O   1 
ATOM   3862 C  CB  . ASP B 1 208 ? -5.867  -18.009 32.080  1.00 28.98 ? 213 ASP B CB  1 
ATOM   3863 C  CG  . ASP B 1 208 ? -4.598  -17.245 31.941  1.00 33.18 ? 213 ASP B CG  1 
ATOM   3864 O  OD1 . ASP B 1 208 ? -4.099  -17.127 30.792  1.00 37.95 ? 213 ASP B OD1 1 
ATOM   3865 O  OD2 . ASP B 1 208 ? -4.121  -16.732 32.972  1.00 36.98 ? 213 ASP B OD2 1 
ATOM   3866 N  N   . ILE B 1 209 ? -9.311  -17.249 31.020  1.00 24.29 ? 214 ILE B N   1 
ATOM   3867 C  CA  . ILE B 1 209 ? -10.277 -17.678 30.030  1.00 22.97 ? 214 ILE B CA  1 
ATOM   3868 C  C   . ILE B 1 209 ? -10.171 -16.749 28.809  1.00 22.32 ? 214 ILE B C   1 
ATOM   3869 O  O   . ILE B 1 209 ? -10.239 -15.521 28.927  1.00 21.71 ? 214 ILE B O   1 
ATOM   3870 C  CB  . ILE B 1 209 ? -11.707 -17.727 30.617  1.00 23.28 ? 214 ILE B CB  1 
ATOM   3871 C  CG1 . ILE B 1 209 ? -11.745 -18.695 31.804  1.00 22.90 ? 214 ILE B CG1 1 
ATOM   3872 C  CG2 . ILE B 1 209 ? -12.763 -18.147 29.539  1.00 22.68 ? 214 ILE B CG2 1 
ATOM   3873 C  CD1 . ILE B 1 209 ? -12.984 -18.577 32.655  1.00 21.91 ? 214 ILE B CD1 1 
ATOM   3874 N  N   . GLN B 1 210 ? -9.983  -17.347 27.643  1.00 21.31 ? 215 GLN B N   1 
ATOM   3875 C  CA  . GLN B 1 210 ? -9.667  -16.578 26.446  1.00 21.23 ? 215 GLN B CA  1 
ATOM   3876 C  C   . GLN B 1 210 ? -10.950 -16.127 25.823  1.00 20.13 ? 215 GLN B C   1 
ATOM   3877 O  O   . GLN B 1 210 ? -11.946 -16.867 25.807  1.00 20.59 ? 215 GLN B O   1 
ATOM   3878 C  CB  . GLN B 1 210 ? -8.856  -17.417 25.443  1.00 21.99 ? 215 GLN B CB  1 
ATOM   3879 C  CG  . GLN B 1 210 ? -7.542  -18.010 25.999  1.00 24.13 ? 215 GLN B CG  1 
ATOM   3880 C  CD  . GLN B 1 210 ? -6.605  -16.954 26.524  1.00 28.46 ? 215 GLN B CD  1 
ATOM   3881 O  OE1 . GLN B 1 210 ? -6.146  -16.082 25.778  1.00 29.30 ? 215 GLN B OE1 1 
ATOM   3882 N  NE2 . GLN B 1 210 ? -6.328  -17.001 27.830  1.00 29.39 ? 215 GLN B NE2 1 
ATOM   3883 N  N   . TYR B 1 211 ? -10.944 -14.899 25.307  1.00 19.55 ? 216 TYR B N   1 
ATOM   3884 C  CA  . TYR B 1 211 ? -12.142 -14.389 24.684  1.00 17.85 ? 216 TYR B CA  1 
ATOM   3885 C  C   . TYR B 1 211 ? -11.817 -13.402 23.560  1.00 17.86 ? 216 TYR B C   1 
ATOM   3886 O  O   . TYR B 1 211 ? -10.773 -12.742 23.546  1.00 18.02 ? 216 TYR B O   1 
ATOM   3887 C  CB  . TYR B 1 211 ? -13.055 -13.754 25.727  1.00 18.09 ? 216 TYR B CB  1 
ATOM   3888 C  CG  . TYR B 1 211 ? -12.439 -12.549 26.420  1.00 19.12 ? 216 TYR B CG  1 
ATOM   3889 C  CD1 . TYR B 1 211 ? -12.568 -11.269 25.874  1.00 21.11 ? 216 TYR B CD1 1 
ATOM   3890 C  CD2 . TYR B 1 211 ? -11.739 -12.689 27.621  1.00 21.76 ? 216 TYR B CD2 1 
ATOM   3891 C  CE1 . TYR B 1 211 ? -12.001 -10.161 26.504  1.00 24.03 ? 216 TYR B CE1 1 
ATOM   3892 C  CE2 . TYR B 1 211 ? -11.182 -11.590 28.269  1.00 23.31 ? 216 TYR B CE2 1 
ATOM   3893 C  CZ  . TYR B 1 211 ? -11.315 -10.327 27.707  1.00 25.01 ? 216 TYR B CZ  1 
ATOM   3894 O  OH  . TYR B 1 211 ? -10.767 -9.218  28.335  1.00 28.81 ? 216 TYR B OH  1 
ATOM   3895 N  N   . PHE B 1 212 ? -12.716 -13.336 22.592  1.00 17.19 ? 217 PHE B N   1 
ATOM   3896 C  CA  . PHE B 1 212 ? -12.602 -12.379 21.524  1.00 16.08 ? 217 PHE B CA  1 
ATOM   3897 C  C   . PHE B 1 212 ? -13.824 -11.473 21.625  1.00 15.73 ? 217 PHE B C   1 
ATOM   3898 O  O   . PHE B 1 212 ? -14.922 -11.843 21.177  1.00 15.87 ? 217 PHE B O   1 
ATOM   3899 C  CB  . PHE B 1 212 ? -12.491 -13.127 20.176  1.00 16.50 ? 217 PHE B CB  1 
ATOM   3900 C  CG  . PHE B 1 212 ? -11.228 -13.945 20.047  1.00 17.38 ? 217 PHE B CG  1 
ATOM   3901 C  CD1 . PHE B 1 212 ? -11.227 -15.302 20.387  1.00 17.33 ? 217 PHE B CD1 1 
ATOM   3902 C  CD2 . PHE B 1 212 ? -10.038 -13.360 19.594  1.00 18.29 ? 217 PHE B CD2 1 
ATOM   3903 C  CE1 . PHE B 1 212 ? -10.049 -16.060 20.281  1.00 20.69 ? 217 PHE B CE1 1 
ATOM   3904 C  CE2 . PHE B 1 212 ? -8.851  -14.100 19.484  1.00 20.75 ? 217 PHE B CE2 1 
ATOM   3905 C  CZ  . PHE B 1 212 ? -8.856  -15.467 19.824  1.00 20.60 ? 217 PHE B CZ  1 
ATOM   3906 N  N   . SER B 1 213 ? -13.653 -10.310 22.267  1.00 15.09 ? 218 SER B N   1 
ATOM   3907 C  CA  . SER B 1 213 ? -14.750 -9.338  22.381  1.00 14.50 ? 218 SER B CA  1 
ATOM   3908 C  C   . SER B 1 213 ? -15.052 -8.755  21.007  1.00 14.83 ? 218 SER B C   1 
ATOM   3909 O  O   . SER B 1 213 ? -14.318 -8.994  20.058  1.00 14.88 ? 218 SER B O   1 
ATOM   3910 C  CB  . SER B 1 213 ? -14.389 -8.188  23.327  1.00 15.44 ? 218 SER B CB  1 
ATOM   3911 O  OG  . SER B 1 213 ? -13.377 -7.342  22.740  1.00 12.97 ? 218 SER B OG  1 
ATOM   3912 N  N   . MET B 1 214 ? -16.122 -7.962  20.921  1.00 14.33 ? 219 MET B N   1 
ATOM   3913 C  CA  . MET B 1 214 ? -16.349 -7.130  19.752  1.00 14.09 ? 219 MET B CA  1 
ATOM   3914 C  C   . MET B 1 214 ? -15.117 -6.312  19.356  1.00 14.42 ? 219 MET B C   1 
ATOM   3915 O  O   . MET B 1 214 ? -14.822 -6.139  18.173  1.00 14.68 ? 219 MET B O   1 
ATOM   3916 C  CB  . MET B 1 214 ? -17.577 -6.256  19.955  1.00 13.38 ? 219 MET B CB  1 
ATOM   3917 C  CG  . MET B 1 214 ? -18.876 -7.095  20.027  1.00 12.12 ? 219 MET B CG  1 
ATOM   3918 S  SD  . MET B 1 214 ? -19.188 -8.402  18.781  1.00 14.58 ? 219 MET B SD  1 
ATOM   3919 C  CE  . MET B 1 214 ? -18.836 -7.490  17.252  1.00 12.19 ? 219 MET B CE  1 
ATOM   3920 N  N   . ARG B 1 215 ? -14.391 -5.818  20.345  1.00 14.83 ? 220 ARG B N   1 
ATOM   3921 C  CA  . ARG B 1 215 ? -13.230 -4.991  20.048  1.00 14.47 ? 220 ARG B CA  1 
ATOM   3922 C  C   . ARG B 1 215 ? -12.117 -5.828  19.426  1.00 14.68 ? 220 ARG B C   1 
ATOM   3923 O  O   . ARG B 1 215 ? -11.449 -5.369  18.524  1.00 14.60 ? 220 ARG B O   1 
ATOM   3924 C  CB  . ARG B 1 215 ? -12.788 -4.250  21.305  1.00 14.87 ? 220 ARG B CB  1 
ATOM   3925 C  CG  . ARG B 1 215 ? -11.398 -3.611  21.198  1.00 16.41 ? 220 ARG B CG  1 
ATOM   3926 C  CD  . ARG B 1 215 ? -10.928 -3.025  22.527  1.00 19.95 ? 220 ARG B CD  1 
ATOM   3927 N  NE  . ARG B 1 215 ? -9.495  -2.727  22.398  1.00 21.55 ? 220 ARG B NE  1 
ATOM   3928 C  CZ  . ARG B 1 215 ? -8.977  -1.582  21.960  1.00 24.97 ? 220 ARG B CZ  1 
ATOM   3929 N  NH1 . ARG B 1 215 ? -9.758  -0.536  21.616  1.00 21.53 ? 220 ARG B NH1 1 
ATOM   3930 N  NH2 . ARG B 1 215 ? -7.653  -1.476  21.871  1.00 22.72 ? 220 ARG B NH2 1 
ATOM   3931 N  N   . ASP B 1 216 ? -11.916 -7.061  19.909  1.00 15.56 ? 221 ASP B N   1 
ATOM   3932 C  CA  . ASP B 1 216 ? -10.944 -7.949  19.289  1.00 14.76 ? 221 ASP B CA  1 
ATOM   3933 C  C   . ASP B 1 216 ? -11.346 -8.281  17.851  1.00 14.73 ? 221 ASP B C   1 
ATOM   3934 O  O   . ASP B 1 216 ? -10.505 -8.386  16.976  1.00 13.42 ? 221 ASP B O   1 
ATOM   3935 C  CB  . ASP B 1 216 ? -10.804 -9.244  20.086  1.00 14.86 ? 221 ASP B CB  1 
ATOM   3936 C  CG  . ASP B 1 216 ? -10.261 -9.007  21.475  1.00 16.99 ? 221 ASP B CG  1 
ATOM   3937 O  OD1 . ASP B 1 216 ? -9.190  -8.375  21.582  1.00 19.30 ? 221 ASP B OD1 1 
ATOM   3938 O  OD2 . ASP B 1 216 ? -10.878 -9.488  22.443  1.00 16.74 ? 221 ASP B OD2 1 
ATOM   3939 N  N   . ILE B 1 217 ? -12.653 -8.464  17.596  1.00 12.92 ? 222 ILE B N   1 
ATOM   3940 C  CA  . ILE B 1 217 ? -13.098 -8.674  16.226  1.00 12.18 ? 222 ILE B CA  1 
ATOM   3941 C  C   . ILE B 1 217 ? -12.852 -7.447  15.339  1.00 12.61 ? 222 ILE B C   1 
ATOM   3942 O  O   . ILE B 1 217 ? -12.476 -7.588  14.163  1.00 12.97 ? 222 ILE B O   1 
ATOM   3943 C  CB  . ILE B 1 217 ? -14.616 -9.135  16.176  1.00 12.19 ? 222 ILE B CB  1 
ATOM   3944 C  CG1 . ILE B 1 217 ? -14.830 -10.399 17.030  1.00 12.43 ? 222 ILE B CG1 1 
ATOM   3945 C  CG2 . ILE B 1 217 ? -15.099 -9.366  14.727  1.00 11.69 ? 222 ILE B CG2 1 
ATOM   3946 C  CD1 . ILE B 1 217 ? -16.376 -10.743 17.290  1.00 11.70 ? 222 ILE B CD1 1 
ATOM   3947 N  N   . ASP B 1 218 ? -13.075 -6.244  15.879  1.00 12.55 ? 223 ASP B N   1 
ATOM   3948 C  CA  . ASP B 1 218 ? -12.837 -5.025  15.130  1.00 13.39 ? 223 ASP B CA  1 
ATOM   3949 C  C   . ASP B 1 218 ? -11.358 -4.926  14.715  1.00 14.52 ? 223 ASP B C   1 
ATOM   3950 O  O   . ASP B 1 218 ? -11.047 -4.380  13.665  1.00 13.95 ? 223 ASP B O   1 
ATOM   3951 C  CB  . ASP B 1 218 ? -13.154 -3.801  15.977  1.00 13.51 ? 223 ASP B CB  1 
ATOM   3952 C  CG  . ASP B 1 218 ? -14.628 -3.658  16.254  1.00 14.03 ? 223 ASP B CG  1 
ATOM   3953 O  OD1 . ASP B 1 218 ? -15.419 -4.182  15.445  1.00 14.33 ? 223 ASP B OD1 1 
ATOM   3954 O  OD2 . ASP B 1 218 ? -14.980 -3.031  17.285  1.00 16.59 ? 223 ASP B OD2 1 
ATOM   3955 N  N   . ARG B 1 219 ? -10.475 -5.427  15.575  1.00 15.10 ? 224 ARG B N   1 
ATOM   3956 C  CA  . ARG B 1 219 ? -9.002  -5.353  15.335  1.00 16.03 ? 224 ARG B CA  1 
ATOM   3957 C  C   . ARG B 1 219 ? -8.509  -6.433  14.389  1.00 16.98 ? 224 ARG B C   1 
ATOM   3958 O  O   . ARG B 1 219 ? -7.819  -6.152  13.395  1.00 17.20 ? 224 ARG B O   1 
ATOM   3959 C  CB  . ARG B 1 219 ? -8.258  -5.444  16.663  1.00 16.39 ? 224 ARG B CB  1 
ATOM   3960 C  CG  . ARG B 1 219 ? -8.346  -4.122  17.452  1.00 18.63 ? 224 ARG B CG  1 
ATOM   3961 C  CD  . ARG B 1 219 ? -7.849  -4.247  18.908  1.00 22.58 ? 224 ARG B CD  1 
ATOM   3962 N  NE  . ARG B 1 219 ? -6.501  -4.818  18.960  1.00 26.28 ? 224 ARG B NE  1 
ATOM   3963 C  CZ  . ARG B 1 219 ? -5.365  -4.112  18.863  1.00 30.62 ? 224 ARG B CZ  1 
ATOM   3964 N  NH1 . ARG B 1 219 ? -5.380  -2.783  18.711  1.00 30.40 ? 224 ARG B NH1 1 
ATOM   3965 N  NH2 . ARG B 1 219 ? -4.199  -4.735  18.921  1.00 29.05 ? 224 ARG B NH2 1 
ATOM   3966 N  N   . LEU B 1 220 ? -8.898  -7.662  14.704  1.00 15.57 ? 225 LEU B N   1 
ATOM   3967 C  CA  . LEU B 1 220 ? -8.383  -8.840  14.030  1.00 16.12 ? 225 LEU B CA  1 
ATOM   3968 C  C   . LEU B 1 220 ? -9.160  -9.226  12.787  1.00 15.97 ? 225 LEU B C   1 
ATOM   3969 O  O   . LEU B 1 220 ? -8.601  -9.771  11.862  1.00 16.79 ? 225 LEU B O   1 
ATOM   3970 C  CB  . LEU B 1 220 ? -8.394  -10.025 15.011  1.00 15.38 ? 225 LEU B CB  1 
ATOM   3971 C  CG  . LEU B 1 220 ? -7.391  -9.994  16.166  1.00 17.27 ? 225 LEU B CG  1 
ATOM   3972 C  CD1 . LEU B 1 220 ? -7.741  -11.096 17.199  1.00 18.02 ? 225 LEU B CD1 1 
ATOM   3973 C  CD2 . LEU B 1 220 ? -6.012  -10.190 15.605  1.00 21.75 ? 225 LEU B CD2 1 
ATOM   3974 N  N   . GLY B 1 221 ? -10.467 -8.988  12.776  1.00 15.99 ? 226 GLY B N   1 
ATOM   3975 C  CA  . GLY B 1 221 ? -11.275 -9.549  11.725  1.00 16.42 ? 226 GLY B CA  1 
ATOM   3976 C  C   . GLY B 1 221 ? -11.718 -10.934 12.145  1.00 16.84 ? 226 GLY B C   1 
ATOM   3977 O  O   . GLY B 1 221 ? -10.988 -11.675 12.818  1.00 16.70 ? 226 GLY B O   1 
ATOM   3978 N  N   . ILE B 1 222 ? -12.938 -11.292 11.765  1.00 16.75 ? 227 ILE B N   1 
ATOM   3979 C  CA  . ILE B 1 222 ? -13.481 -12.586 12.162  1.00 15.79 ? 227 ILE B CA  1 
ATOM   3980 C  C   . ILE B 1 222 ? -12.687 -13.835 11.659  1.00 16.32 ? 227 ILE B C   1 
ATOM   3981 O  O   . ILE B 1 222 ? -12.698 -14.858 12.365  1.00 15.86 ? 227 ILE B O   1 
ATOM   3982 C  CB  . ILE B 1 222 ? -14.971 -12.675 11.778  1.00 15.51 ? 227 ILE B CB  1 
ATOM   3983 C  CG1 . ILE B 1 222 ? -15.674 -13.792 12.548  1.00 16.61 ? 227 ILE B CG1 1 
ATOM   3984 C  CG2 . ILE B 1 222 ? -15.138 -12.834 10.235  1.00 16.09 ? 227 ILE B CG2 1 
ATOM   3985 C  CD1 . ILE B 1 222 ? -15.825 -13.506 14.097  1.00 17.70 ? 227 ILE B CD1 1 
ATOM   3986 N  N   . GLN B 1 223 ? -12.029 -13.765 10.481  1.00 16.59 ? 228 GLN B N   1 
ATOM   3987 C  CA  . GLN B 1 223 ? -11.161 -14.893 9.992   1.00 18.18 ? 228 GLN B CA  1 
ATOM   3988 C  C   . GLN B 1 223 ? -10.083 -15.221 11.008  1.00 17.03 ? 228 GLN B C   1 
ATOM   3989 O  O   . GLN B 1 223 ? -9.964  -16.373 11.454  1.00 17.47 ? 228 GLN B O   1 
ATOM   3990 C  CB  . GLN B 1 223 ? -10.480 -14.652 8.616   1.00 18.04 ? 228 GLN B CB  1 
ATOM   3991 C  CG  . GLN B 1 223 ? -9.186  -15.587 8.350   1.00 21.75 ? 228 GLN B CG  1 
ATOM   3992 C  CD  . GLN B 1 223 ? -8.457  -15.329 7.019   1.00 25.58 ? 228 GLN B CD  1 
ATOM   3993 O  OE1 . GLN B 1 223 ? -7.457  -16.008 6.682   1.00 28.86 ? 228 GLN B OE1 1 
ATOM   3994 N  NE2 . GLN B 1 223 ? -8.933  -14.357 6.265   1.00 25.02 ? 228 GLN B NE2 1 
ATOM   3995 N  N   . LYS B 1 224 ? -9.286  -14.214 11.351  1.00 16.96 ? 229 LYS B N   1 
ATOM   3996 C  CA  . LYS B 1 224 ? -8.281  -14.354 12.416  1.00 17.40 ? 229 LYS B CA  1 
ATOM   3997 C  C   . LYS B 1 224 ? -8.852  -14.755 13.767  1.00 16.59 ? 229 LYS B C   1 
ATOM   3998 O  O   . LYS B 1 224 ? -8.210  -15.505 14.513  1.00 16.15 ? 229 LYS B O   1 
ATOM   3999 C  CB  . LYS B 1 224 ? -7.368  -13.124 12.525  1.00 17.65 ? 229 LYS B CB  1 
ATOM   4000 C  CG  . LYS B 1 224 ? -6.516  -12.919 11.254  1.00 22.45 ? 229 LYS B CG  1 
ATOM   4001 C  CD  . LYS B 1 224 ? -5.267  -12.004 11.449  1.00 30.92 ? 229 LYS B CD  1 
ATOM   4002 C  CE  . LYS B 1 224 ? -4.537  -12.278 12.773  1.00 35.47 ? 229 LYS B CE  1 
ATOM   4003 N  NZ  . LYS B 1 224 ? -3.043  -12.024 12.733  1.00 39.30 ? 229 LYS B NZ  1 
ATOM   4004 N  N   . VAL B 1 225 ? -10.054 -14.287 14.095  1.00 15.91 ? 230 VAL B N   1 
ATOM   4005 C  CA  . VAL B 1 225 ? -10.625 -14.664 15.381  1.00 16.06 ? 230 VAL B CA  1 
ATOM   4006 C  C   . VAL B 1 225 ? -10.874 -16.179 15.405  1.00 16.53 ? 230 VAL B C   1 
ATOM   4007 O  O   . VAL B 1 225 ? -10.569 -16.851 16.401  1.00 16.97 ? 230 VAL B O   1 
ATOM   4008 C  CB  . VAL B 1 225 ? -11.914 -13.856 15.714  1.00 15.95 ? 230 VAL B CB  1 
ATOM   4009 C  CG1 . VAL B 1 225 ? -12.757 -14.612 16.774  1.00 17.13 ? 230 VAL B CG1 1 
ATOM   4010 C  CG2 . VAL B 1 225 ? -11.518 -12.437 16.211  1.00 15.44 ? 230 VAL B CG2 1 
ATOM   4011 N  N   . MET B 1 226 ? -11.387 -16.713 14.300  1.00 16.71 ? 231 MET B N   1 
ATOM   4012 C  CA  . MET B 1 226 ? -11.665 -18.149 14.198  1.00 16.85 ? 231 MET B CA  1 
ATOM   4013 C  C   . MET B 1 226 ? -10.380 -18.988 14.185  1.00 17.25 ? 231 MET B C   1 
ATOM   4014 O  O   . MET B 1 226 ? -10.334 -20.022 14.851  1.00 17.46 ? 231 MET B O   1 
ATOM   4015 C  CB  . MET B 1 226 ? -12.528 -18.457 12.995  1.00 16.09 ? 231 MET B CB  1 
ATOM   4016 C  CG  . MET B 1 226 ? -13.958 -17.896 13.111  1.00 16.96 ? 231 MET B CG  1 
ATOM   4017 S  SD  . MET B 1 226 ? -14.775 -18.151 14.726  1.00 17.62 ? 231 MET B SD  1 
ATOM   4018 C  CE  . MET B 1 226 ? -14.886 -19.976 14.773  1.00 15.52 ? 231 MET B CE  1 
ATOM   4019 N  N   . GLU B 1 227 ? -9.348  -18.512 13.490  1.00 17.51 ? 232 GLU B N   1 
ATOM   4020 C  CA  . GLU B 1 227 ? -8.063  -19.216 13.438  1.00 19.40 ? 232 GLU B CA  1 
ATOM   4021 C  C   . GLU B 1 227 ? -7.526  -19.368 14.851  1.00 19.54 ? 232 GLU B C   1 
ATOM   4022 O  O   . GLU B 1 227 ? -7.121  -20.472 15.267  1.00 19.02 ? 232 GLU B O   1 
ATOM   4023 C  CB  . GLU B 1 227 ? -7.031  -18.506 12.527  1.00 19.46 ? 232 GLU B CB  1 
ATOM   4024 C  CG  . GLU B 1 227 ? -7.302  -18.752 11.006  1.00 22.46 ? 232 GLU B CG  1 
ATOM   4025 C  CD  . GLU B 1 227 ? -6.519  -17.828 10.058  1.00 26.31 ? 232 GLU B CD  1 
ATOM   4026 O  OE1 . GLU B 1 227 ? -5.770  -16.964 10.548  1.00 27.19 ? 232 GLU B OE1 1 
ATOM   4027 O  OE2 . GLU B 1 227 ? -6.692  -17.950 8.805   1.00 27.48 ? 232 GLU B OE2 1 
ATOM   4028 N  N   . ARG B 1 228 ? -7.546  -18.258 15.593  1.00 19.00 ? 233 ARG B N   1 
ATOM   4029 C  CA  . ARG B 1 228 ? -6.970  -18.243 16.923  1.00 19.67 ? 233 ARG B CA  1 
ATOM   4030 C  C   . ARG B 1 228 ? -7.805  -19.017 17.912  1.00 19.37 ? 233 ARG B C   1 
ATOM   4031 O  O   . ARG B 1 228 ? -7.244  -19.637 18.817  1.00 20.11 ? 233 ARG B O   1 
ATOM   4032 C  CB  . ARG B 1 228 ? -6.721  -16.818 17.397  1.00 19.65 ? 233 ARG B CB  1 
ATOM   4033 C  CG  . ARG B 1 228 ? -5.569  -16.176 16.654  1.00 22.96 ? 233 ARG B CG  1 
ATOM   4034 C  CD  . ARG B 1 228 ? -5.443  -14.735 17.081  1.00 28.06 ? 233 ARG B CD  1 
ATOM   4035 N  NE  . ARG B 1 228 ? -4.419  -14.055 16.309  1.00 30.91 ? 233 ARG B NE  1 
ATOM   4036 C  CZ  . ARG B 1 228 ? -3.745  -12.982 16.724  1.00 32.15 ? 233 ARG B CZ  1 
ATOM   4037 N  NH1 . ARG B 1 228 ? -3.987  -12.448 17.915  1.00 33.18 ? 233 ARG B NH1 1 
ATOM   4038 N  NH2 . ARG B 1 228 ? -2.826  -12.441 15.938  1.00 32.81 ? 233 ARG B NH2 1 
ATOM   4039 N  N   . THR B 1 229 ? -9.131  -18.996 17.744  1.00 18.82 ? 234 THR B N   1 
ATOM   4040 C  CA  . THR B 1 229 ? -10.063 -19.801 18.564  1.00 18.42 ? 234 THR B CA  1 
ATOM   4041 C  C   . THR B 1 229 ? -9.766  -21.310 18.447  1.00 19.99 ? 234 THR B C   1 
ATOM   4042 O  O   . THR B 1 229 ? -9.710  -22.038 19.462  1.00 19.51 ? 234 THR B O   1 
ATOM   4043 C  CB  . THR B 1 229 ? -11.545 -19.533 18.155  1.00 18.93 ? 234 THR B CB  1 
ATOM   4044 O  OG1 . THR B 1 229 ? -11.905 -18.199 18.527  1.00 15.20 ? 234 THR B OG1 1 
ATOM   4045 C  CG2 . THR B 1 229 ? -12.546 -20.520 18.827  1.00 19.07 ? 234 THR B CG2 1 
ATOM   4046 N  N   . PHE B 1 230 ? -9.599  -21.766 17.212  1.00 19.64 ? 235 PHE B N   1 
ATOM   4047 C  CA  . PHE B 1 230 ? -9.283  -23.154 16.966  1.00 20.68 ? 235 PHE B CA  1 
ATOM   4048 C  C   . PHE B 1 230 ? -7.862  -23.494 17.421  1.00 20.58 ? 235 PHE B C   1 
ATOM   4049 O  O   . PHE B 1 230 ? -7.631  -24.581 17.959  1.00 20.96 ? 235 PHE B O   1 
ATOM   4050 C  CB  . PHE B 1 230 ? -9.490  -23.479 15.503  1.00 20.38 ? 235 PHE B CB  1 
ATOM   4051 C  CG  . PHE B 1 230 ? -10.922 -23.399 15.068  1.00 21.37 ? 235 PHE B CG  1 
ATOM   4052 C  CD1 . PHE B 1 230 ? -11.938 -23.740 15.936  1.00 20.49 ? 235 PHE B CD1 1 
ATOM   4053 C  CD2 . PHE B 1 230 ? -11.246 -22.999 13.765  1.00 21.95 ? 235 PHE B CD2 1 
ATOM   4054 C  CE1 . PHE B 1 230 ? -13.288 -23.694 15.512  1.00 23.91 ? 235 PHE B CE1 1 
ATOM   4055 C  CE2 . PHE B 1 230 ? -12.552 -22.944 13.340  1.00 22.76 ? 235 PHE B CE2 1 
ATOM   4056 C  CZ  . PHE B 1 230 ? -13.589 -23.296 14.208  1.00 21.37 ? 235 PHE B CZ  1 
ATOM   4057 N  N   . ASP B 1 231 ? -6.931  -22.569 17.249  1.00 21.83 ? 236 ASP B N   1 
ATOM   4058 C  CA  . ASP B 1 231 ? -5.569  -22.756 17.771  1.00 22.87 ? 236 ASP B CA  1 
ATOM   4059 C  C   . ASP B 1 231 ? -5.621  -23.052 19.285  1.00 23.24 ? 236 ASP B C   1 
ATOM   4060 O  O   . ASP B 1 231 ? -4.885  -23.901 19.793  1.00 23.46 ? 236 ASP B O   1 
ATOM   4061 C  CB  . ASP B 1 231 ? -4.691  -21.519 17.551  1.00 23.37 ? 236 ASP B CB  1 
ATOM   4062 C  CG  . ASP B 1 231 ? -4.182  -21.353 16.102  1.00 27.49 ? 236 ASP B CG  1 
ATOM   4063 O  OD1 . ASP B 1 231 ? -4.184  -22.306 15.278  1.00 29.40 ? 236 ASP B OD1 1 
ATOM   4064 O  OD2 . ASP B 1 231 ? -3.738  -20.224 15.804  1.00 30.06 ? 236 ASP B OD2 1 
ATOM   4065 N  N   . LEU B 1 232 ? -6.493  -22.340 20.007  1.00 23.13 ? 237 LEU B N   1 
ATOM   4066 C  CA  . LEU B 1 232 ? -6.563  -22.467 21.455  1.00 22.64 ? 237 LEU B CA  1 
ATOM   4067 C  C   . LEU B 1 232 ? -7.259  -23.760 21.878  1.00 22.69 ? 237 LEU B C   1 
ATOM   4068 O  O   . LEU B 1 232 ? -6.845  -24.382 22.855  1.00 23.20 ? 237 LEU B O   1 
ATOM   4069 C  CB  . LEU B 1 232 ? -7.240  -21.214 22.086  1.00 22.30 ? 237 LEU B CB  1 
ATOM   4070 C  CG  . LEU B 1 232 ? -6.506  -19.857 22.006  1.00 23.33 ? 237 LEU B CG  1 
ATOM   4071 C  CD1 . LEU B 1 232 ? -7.459  -18.685 22.242  1.00 23.43 ? 237 LEU B CD1 1 
ATOM   4072 C  CD2 . LEU B 1 232 ? -5.258  -19.753 22.945  1.00 23.29 ? 237 LEU B CD2 1 
ATOM   4073 N  N   . LEU B 1 233 ? -8.313  -24.154 21.156  1.00 21.88 ? 238 LEU B N   1 
ATOM   4074 C  CA  . LEU B 1 233 ? -9.187  -25.254 21.574  1.00 21.45 ? 238 LEU B CA  1 
ATOM   4075 C  C   . LEU B 1 233 ? -8.775  -26.597 20.980  1.00 22.31 ? 238 LEU B C   1 
ATOM   4076 O  O   . LEU B 1 233 ? -8.765  -27.614 21.680  1.00 22.59 ? 238 LEU B O   1 
ATOM   4077 C  CB  . LEU B 1 233 ? -10.629 -24.945 21.207  1.00 21.33 ? 238 LEU B CB  1 
ATOM   4078 C  CG  . LEU B 1 233 ? -11.234 -23.751 21.960  1.00 19.10 ? 238 LEU B CG  1 
ATOM   4079 C  CD1 . LEU B 1 233 ? -12.681 -23.547 21.528  1.00 17.80 ? 238 LEU B CD1 1 
ATOM   4080 C  CD2 . LEU B 1 233 ? -11.159 -24.020 23.471  1.00 21.64 ? 238 LEU B CD2 1 
ATOM   4081 N  N   . ILE B 1 234 ? -8.435  -26.597 19.687  1.00 22.74 ? 239 ILE B N   1 
ATOM   4082 C  CA  . ILE B 1 234 ? -8.026  -27.829 18.990  1.00 22.11 ? 239 ILE B CA  1 
ATOM   4083 C  C   . ILE B 1 234 ? -6.617  -27.761 18.372  1.00 23.09 ? 239 ILE B C   1 
ATOM   4084 O  O   . ILE B 1 234 ? -6.300  -28.543 17.472  1.00 23.40 ? 239 ILE B O   1 
ATOM   4085 C  CB  . ILE B 1 234 ? -9.069  -28.243 17.941  1.00 22.10 ? 239 ILE B CB  1 
ATOM   4086 C  CG1 . ILE B 1 234 ? -9.196  -27.169 16.822  1.00 22.10 ? 239 ILE B CG1 1 
ATOM   4087 C  CG2 . ILE B 1 234 ? -10.416 -28.573 18.625  1.00 20.76 ? 239 ILE B CG2 1 
ATOM   4088 C  CD1 . ILE B 1 234 ? -10.291 -27.457 15.792  1.00 21.93 ? 239 ILE B CD1 1 
ATOM   4089 N  N   . GLY B 1 235 ? -5.775  -26.848 18.851  1.00 23.23 ? 240 GLY B N   1 
ATOM   4090 C  CA  . GLY B 1 235 ? -4.382  -26.723 18.364  1.00 25.53 ? 240 GLY B CA  1 
ATOM   4091 C  C   . GLY B 1 235 ? -3.471  -27.927 18.642  1.00 27.21 ? 240 GLY B C   1 
ATOM   4092 O  O   . GLY B 1 235 ? -2.461  -28.195 17.918  1.00 27.20 ? 240 GLY B O   1 
ATOM   4093 N  N   . LYS B 1 236 ? -3.830  -28.653 19.691  1.00 27.59 ? 241 LYS B N   1 
ATOM   4094 C  CA  . LYS B 1 236 ? -3.072  -29.820 20.149  1.00 28.46 ? 241 LYS B CA  1 
ATOM   4095 C  C   . LYS B 1 236 ? -3.645  -31.128 19.625  1.00 27.96 ? 241 LYS B C   1 
ATOM   4096 O  O   . LYS B 1 236 ? -2.912  -32.085 19.436  1.00 27.55 ? 241 LYS B O   1 
ATOM   4097 C  CB  . LYS B 1 236 ? -3.084  -29.862 21.678  1.00 28.88 ? 241 LYS B CB  1 
ATOM   4098 C  CG  . LYS B 1 236 ? -2.326  -28.724 22.317  1.00 31.98 ? 241 LYS B CG  1 
ATOM   4099 C  CD  . LYS B 1 236 ? -2.448  -28.772 23.841  1.00 36.26 ? 241 LYS B CD  1 
ATOM   4100 C  CE  . LYS B 1 236 ? -1.321  -27.988 24.484  1.00 38.22 ? 241 LYS B CE  1 
ATOM   4101 N  NZ  . LYS B 1 236 ? -0.015  -28.416 23.916  1.00 40.31 ? 241 LYS B NZ  1 
ATOM   4102 N  N   . ARG B 1 237 ? -4.958  -31.171 19.417  1.00 27.67 ? 242 ARG B N   1 
ATOM   4103 C  CA  . ARG B 1 237 ? -5.634  -32.398 19.036  1.00 27.88 ? 242 ARG B CA  1 
ATOM   4104 C  C   . ARG B 1 237 ? -7.052  -32.085 18.590  1.00 28.28 ? 242 ARG B C   1 
ATOM   4105 O  O   . ARG B 1 237 ? -7.615  -31.052 18.968  1.00 27.92 ? 242 ARG B O   1 
ATOM   4106 C  CB  . ARG B 1 237 ? -5.641  -33.371 20.242  1.00 28.50 ? 242 ARG B CB  1 
ATOM   4107 C  CG  . ARG B 1 237 ? -6.578  -32.978 21.366  1.00 28.77 ? 242 ARG B CG  1 
ATOM   4108 C  CD  . ARG B 1 237 ? -6.524  -33.924 22.572  1.00 30.37 ? 242 ARG B CD  1 
ATOM   4109 N  NE  . ARG B 1 237 ? -7.185  -33.285 23.711  1.00 30.17 ? 242 ARG B NE  1 
ATOM   4110 C  CZ  . ARG B 1 237 ? -6.581  -32.432 24.537  1.00 28.67 ? 242 ARG B CZ  1 
ATOM   4111 N  NH1 . ARG B 1 237 ? -5.290  -32.175 24.401  1.00 25.77 ? 242 ARG B NH1 1 
ATOM   4112 N  NH2 . ARG B 1 237 ? -7.267  -31.862 25.528  1.00 25.99 ? 242 ARG B NH2 1 
ATOM   4113 N  N   . GLN B 1 238 ? -7.642  -32.977 17.808  1.00 28.14 ? 243 GLN B N   1 
ATOM   4114 C  CA  . GLN B 1 238 ? -9.068  -32.920 17.523  1.00 28.91 ? 243 GLN B CA  1 
ATOM   4115 C  C   . GLN B 1 238 ? -9.931  -33.258 18.746  1.00 28.14 ? 243 GLN B C   1 
ATOM   4116 O  O   . GLN B 1 238 ? -9.620  -34.175 19.508  1.00 28.47 ? 243 GLN B O   1 
ATOM   4117 C  CB  . GLN B 1 238 ? -9.399  -33.851 16.364  1.00 29.53 ? 243 GLN B CB  1 
ATOM   4118 C  CG  . GLN B 1 238 ? -8.481  -33.624 15.165  1.00 33.43 ? 243 GLN B CG  1 
ATOM   4119 C  CD  . GLN B 1 238 ? -8.879  -34.448 13.967  1.00 38.90 ? 243 GLN B CD  1 
ATOM   4120 O  OE1 . GLN B 1 238 ? -9.583  -35.453 14.087  1.00 41.45 ? 243 GLN B OE1 1 
ATOM   4121 N  NE2 . GLN B 1 238 ? -8.419  -34.030 12.791  1.00 42.19 ? 243 GLN B NE2 1 
ATOM   4122 N  N   . ARG B 1 239 ? -11.009 -32.495 18.930  1.00 27.22 ? 244 ARG B N   1 
ATOM   4123 C  CA  . ARG B 1 239 ? -11.887 -32.623 20.095  1.00 25.25 ? 244 ARG B CA  1 
ATOM   4124 C  C   . ARG B 1 239 ? -13.301 -32.387 19.662  1.00 23.95 ? 244 ARG B C   1 
ATOM   4125 O  O   . ARG B 1 239 ? -13.537 -31.648 18.692  1.00 24.11 ? 244 ARG B O   1 
ATOM   4126 C  CB  . ARG B 1 239 ? -11.544 -31.566 21.146  1.00 25.34 ? 244 ARG B CB  1 
ATOM   4127 C  CG  . ARG B 1 239 ? -10.110 -31.530 21.587  1.00 24.66 ? 244 ARG B CG  1 
ATOM   4128 C  CD  . ARG B 1 239 ? -9.846  -30.294 22.423  1.00 26.09 ? 244 ARG B CD  1 
ATOM   4129 N  NE  . ARG B 1 239 ? -10.342 -30.435 23.789  1.00 24.60 ? 244 ARG B NE  1 
ATOM   4130 C  CZ  . ARG B 1 239 ? -10.041 -29.615 24.793  1.00 24.06 ? 244 ARG B CZ  1 
ATOM   4131 N  NH1 . ARG B 1 239 ? -9.252  -28.549 24.609  1.00 22.76 ? 244 ARG B NH1 1 
ATOM   4132 N  NH2 . ARG B 1 239 ? -10.562 -29.852 25.991  1.00 24.95 ? 244 ARG B NH2 1 
ATOM   4133 N  N   . PRO B 1 240 ? -14.276 -32.966 20.385  1.00 22.84 ? 245 PRO B N   1 
ATOM   4134 C  CA  . PRO B 1 240 ? -15.656 -32.690 20.051  1.00 21.90 ? 245 PRO B CA  1 
ATOM   4135 C  C   . PRO B 1 240 ? -15.921 -31.198 20.356  1.00 21.05 ? 245 PRO B C   1 
ATOM   4136 O  O   . PRO B 1 240 ? -15.370 -30.661 21.333  1.00 20.95 ? 245 PRO B O   1 
ATOM   4137 C  CB  . PRO B 1 240 ? -16.436 -33.622 21.014  1.00 22.74 ? 245 PRO B CB  1 
ATOM   4138 C  CG  . PRO B 1 240 ? -15.417 -34.700 21.345  1.00 22.15 ? 245 PRO B CG  1 
ATOM   4139 C  CD  . PRO B 1 240 ? -14.183 -33.905 21.523  1.00 23.17 ? 245 PRO B CD  1 
ATOM   4140 N  N   . ILE B 1 241 ? -16.682 -30.534 19.481  1.00 20.06 ? 246 ILE B N   1 
ATOM   4141 C  CA  . ILE B 1 241 ? -17.016 -29.126 19.673  1.00 18.73 ? 246 ILE B CA  1 
ATOM   4142 C  C   . ILE B 1 241 ? -18.467 -28.947 20.079  1.00 17.76 ? 246 ILE B C   1 
ATOM   4143 O  O   . ILE B 1 241 ? -19.389 -29.483 19.448  1.00 18.35 ? 246 ILE B O   1 
ATOM   4144 C  CB  . ILE B 1 241 ? -16.684 -28.256 18.408  1.00 18.98 ? 246 ILE B CB  1 
ATOM   4145 C  CG1 . ILE B 1 241 ? -15.158 -28.215 18.166  1.00 19.56 ? 246 ILE B CG1 1 
ATOM   4146 C  CG2 . ILE B 1 241 ? -17.251 -26.817 18.593  1.00 19.41 ? 246 ILE B CG2 1 
ATOM   4147 C  CD1 . ILE B 1 241 ? -14.712 -27.538 16.771  1.00 19.41 ? 246 ILE B CD1 1 
ATOM   4148 N  N   . HIS B 1 242 ? -18.663 -28.153 21.134  1.00 17.43 ? 247 HIS B N   1 
ATOM   4149 C  CA  . HIS B 1 242 ? -19.961 -27.738 21.562  1.00 16.73 ? 247 HIS B CA  1 
ATOM   4150 C  C   . HIS B 1 242 ? -20.068 -26.243 21.250  1.00 16.58 ? 247 HIS B C   1 
ATOM   4151 O  O   . HIS B 1 242 ? -19.308 -25.441 21.817  1.00 17.35 ? 247 HIS B O   1 
ATOM   4152 C  CB  . HIS B 1 242 ? -20.120 -27.960 23.084  1.00 17.76 ? 247 HIS B CB  1 
ATOM   4153 C  CG  . HIS B 1 242 ? -21.511 -27.690 23.565  1.00 18.61 ? 247 HIS B CG  1 
ATOM   4154 N  ND1 . HIS B 1 242 ? -22.400 -28.698 23.871  1.00 19.50 ? 247 HIS B ND1 1 
ATOM   4155 C  CD2 . HIS B 1 242 ? -22.194 -26.529 23.702  1.00 18.01 ? 247 HIS B CD2 1 
ATOM   4156 C  CE1 . HIS B 1 242 ? -23.567 -28.169 24.195  1.00 18.88 ? 247 HIS B CE1 1 
ATOM   4157 N  NE2 . HIS B 1 242 ? -23.472 -26.854 24.091  1.00 19.97 ? 247 HIS B NE2 1 
ATOM   4158 N  N   . LEU B 1 243 ? -20.998 -25.872 20.374  1.00 16.38 ? 248 LEU B N   1 
ATOM   4159 C  CA  . LEU B 1 243 ? -21.200 -24.465 20.020  1.00 16.37 ? 248 LEU B CA  1 
ATOM   4160 C  C   . LEU B 1 243 ? -22.419 -23.951 20.731  1.00 16.06 ? 248 LEU B C   1 
ATOM   4161 O  O   . LEU B 1 243 ? -23.542 -24.366 20.420  1.00 15.74 ? 248 LEU B O   1 
ATOM   4162 C  CB  . LEU B 1 243 ? -21.393 -24.304 18.503  1.00 16.16 ? 248 LEU B CB  1 
ATOM   4163 C  CG  . LEU B 1 243 ? -21.737 -22.900 17.970  1.00 18.14 ? 248 LEU B CG  1 
ATOM   4164 C  CD1 . LEU B 1 243 ? -20.616 -21.923 18.273  1.00 15.54 ? 248 LEU B CD1 1 
ATOM   4165 C  CD2 . LEU B 1 243 ? -22.033 -22.979 16.437  1.00 17.42 ? 248 LEU B CD2 1 
ATOM   4166 N  N   . SER B 1 244 ? -22.204 -23.060 21.700  1.00 15.99 ? 249 SER B N   1 
ATOM   4167 C  CA  . SER B 1 244 ? -23.333 -22.512 22.422  1.00 16.26 ? 249 SER B CA  1 
ATOM   4168 C  C   . SER B 1 244 ? -23.540 -21.098 21.896  1.00 16.06 ? 249 SER B C   1 
ATOM   4169 O  O   . SER B 1 244 ? -22.706 -20.206 22.127  1.00 16.28 ? 249 SER B O   1 
ATOM   4170 C  CB  . SER B 1 244 ? -23.088 -22.515 23.946  1.00 15.11 ? 249 SER B CB  1 
ATOM   4171 O  OG  . SER B 1 244 ? -24.337 -22.300 24.573  1.00 17.84 ? 249 SER B OG  1 
ATOM   4172 N  N   . PHE B 1 245 ? -24.644 -20.918 21.189  1.00 15.86 ? 250 PHE B N   1 
ATOM   4173 C  CA  . PHE B 1 245 ? -24.844 -19.746 20.367  1.00 16.25 ? 250 PHE B CA  1 
ATOM   4174 C  C   . PHE B 1 245 ? -26.102 -18.989 20.806  1.00 16.29 ? 250 PHE B C   1 
ATOM   4175 O  O   . PHE B 1 245 ? -27.240 -19.425 20.616  1.00 16.23 ? 250 PHE B O   1 
ATOM   4176 C  CB  . PHE B 1 245 ? -24.865 -20.143 18.870  1.00 14.65 ? 250 PHE B CB  1 
ATOM   4177 C  CG  . PHE B 1 245 ? -24.607 -18.998 17.912  1.00 18.09 ? 250 PHE B CG  1 
ATOM   4178 C  CD1 . PHE B 1 245 ? -25.414 -17.870 17.931  1.00 16.17 ? 250 PHE B CD1 1 
ATOM   4179 C  CD2 . PHE B 1 245 ? -23.573 -19.069 16.950  1.00 16.73 ? 250 PHE B CD2 1 
ATOM   4180 C  CE1 . PHE B 1 245 ? -25.181 -16.789 17.051  1.00 18.54 ? 250 PHE B CE1 1 
ATOM   4181 C  CE2 . PHE B 1 245 ? -23.341 -17.985 16.052  1.00 15.85 ? 250 PHE B CE2 1 
ATOM   4182 C  CZ  . PHE B 1 245 ? -24.148 -16.860 16.113  1.00 15.00 ? 250 PHE B CZ  1 
ATOM   4183 N  N   . ASP B 1 246 ? -25.866 -17.824 21.392  1.00 16.81 ? 251 ASP B N   1 
ATOM   4184 C  CA  . ASP B 1 246 ? -26.926 -16.968 21.833  1.00 16.29 ? 251 ASP B CA  1 
ATOM   4185 C  C   . ASP B 1 246 ? -27.192 -16.010 20.685  1.00 16.54 ? 251 ASP B C   1 
ATOM   4186 O  O   . ASP B 1 246 ? -26.284 -15.286 20.241  1.00 16.00 ? 251 ASP B O   1 
ATOM   4187 C  CB  . ASP B 1 246 ? -26.437 -16.204 23.087  1.00 16.40 ? 251 ASP B CB  1 
ATOM   4188 C  CG  . ASP B 1 246 ? -27.505 -15.318 23.732  1.00 15.68 ? 251 ASP B CG  1 
ATOM   4189 O  OD1 . ASP B 1 246 ? -28.461 -14.836 23.083  1.00 18.13 ? 251 ASP B OD1 1 
ATOM   4190 O  OD2 . ASP B 1 246 ? -27.334 -15.043 24.944  1.00 19.34 ? 251 ASP B OD2 1 
ATOM   4191 N  N   . ILE B 1 247 ? -28.443 -15.975 20.237  1.00 15.53 ? 252 ILE B N   1 
ATOM   4192 C  CA  . ILE B 1 247 ? -28.853 -15.110 19.151  1.00 15.86 ? 252 ILE B CA  1 
ATOM   4193 C  C   . ILE B 1 247 ? -28.473 -13.641 19.413  1.00 15.28 ? 252 ILE B C   1 
ATOM   4194 O  O   . ILE B 1 247 ? -28.270 -12.901 18.462  1.00 15.15 ? 252 ILE B O   1 
ATOM   4195 C  CB  . ILE B 1 247 ? -30.403 -15.294 18.846  1.00 15.83 ? 252 ILE B CB  1 
ATOM   4196 C  CG1 . ILE B 1 247 ? -30.749 -14.862 17.418  1.00 16.20 ? 252 ILE B CG1 1 
ATOM   4197 C  CG2 . ILE B 1 247 ? -31.289 -14.578 19.920  1.00 17.10 ? 252 ILE B CG2 1 
ATOM   4198 C  CD1 . ILE B 1 247 ? -30.155 -15.761 16.284  1.00 16.32 ? 252 ILE B CD1 1 
ATOM   4199 N  N   . ASP B 1 248 ? -28.385 -13.235 20.689  1.00 15.33 ? 253 ASP B N   1 
ATOM   4200 C  CA  . ASP B 1 248 ? -28.072 -11.823 21.038  1.00 15.97 ? 253 ASP B CA  1 
ATOM   4201 C  C   . ASP B 1 248 ? -26.573 -11.487 20.803  1.00 15.56 ? 253 ASP B C   1 
ATOM   4202 O  O   . ASP B 1 248 ? -26.150 -10.335 20.948  1.00 15.82 ? 253 ASP B O   1 
ATOM   4203 C  CB  . ASP B 1 248 ? -28.590 -11.423 22.466  1.00 16.51 ? 253 ASP B CB  1 
ATOM   4204 C  CG  . ASP B 1 248 ? -27.720 -11.962 23.610  1.00 18.53 ? 253 ASP B CG  1 
ATOM   4205 O  OD1 . ASP B 1 248 ? -26.579 -12.392 23.373  1.00 17.65 ? 253 ASP B OD1 1 
ATOM   4206 O  OD2 . ASP B 1 248 ? -28.198 -12.033 24.780  1.00 21.53 ? 253 ASP B OD2 1 
ATOM   4207 N  N   . ALA B 1 249 ? -25.775 -12.478 20.394  1.00 15.06 ? 254 ALA B N   1 
ATOM   4208 C  CA  . ALA B 1 249 ? -24.425 -12.172 19.804  1.00 13.60 ? 254 ALA B CA  1 
ATOM   4209 C  C   . ALA B 1 249 ? -24.559 -11.224 18.585  1.00 14.15 ? 254 ALA B C   1 
ATOM   4210 O  O   . ALA B 1 249 ? -23.688 -10.372 18.360  1.00 14.45 ? 254 ALA B O   1 
ATOM   4211 C  CB  . ALA B 1 249 ? -23.716 -13.453 19.382  1.00 13.02 ? 254 ALA B CB  1 
ATOM   4212 N  N   . PHE B 1 250 ? -25.638 -11.367 17.810  1.00 13.09 ? 255 PHE B N   1 
ATOM   4213 C  CA  . PHE B 1 250 ? -25.850 -10.525 16.626  1.00 14.22 ? 255 PHE B CA  1 
ATOM   4214 C  C   . PHE B 1 250 ? -26.338 -9.158  17.064  1.00 14.84 ? 255 PHE B C   1 
ATOM   4215 O  O   . PHE B 1 250 ? -27.036 -9.025  18.071  1.00 15.77 ? 255 PHE B O   1 
ATOM   4216 C  CB  . PHE B 1 250 ? -26.898 -11.072 15.679  1.00 14.17 ? 255 PHE B CB  1 
ATOM   4217 C  CG  . PHE B 1 250 ? -26.476 -12.301 14.904  1.00 14.21 ? 255 PHE B CG  1 
ATOM   4218 C  CD1 . PHE B 1 250 ? -25.614 -12.194 13.796  1.00 13.70 ? 255 PHE B CD1 1 
ATOM   4219 C  CD2 . PHE B 1 250 ? -26.977 -13.554 15.243  1.00 16.04 ? 255 PHE B CD2 1 
ATOM   4220 C  CE1 . PHE B 1 250 ? -25.255 -13.313 13.044  1.00 12.57 ? 255 PHE B CE1 1 
ATOM   4221 C  CE2 . PHE B 1 250 ? -26.621 -14.692 14.494  1.00 15.45 ? 255 PHE B CE2 1 
ATOM   4222 C  CZ  . PHE B 1 250 ? -25.739 -14.556 13.386  1.00 16.78 ? 255 PHE B CZ  1 
ATOM   4223 N  N   . ASP B 1 251 ? -26.020 -8.157  16.267  1.00 15.02 ? 256 ASP B N   1 
ATOM   4224 C  CA  . ASP B 1 251 ? -26.511 -6.827  16.523  1.00 15.48 ? 256 ASP B CA  1 
ATOM   4225 C  C   . ASP B 1 251 ? -28.053 -6.869  16.633  1.00 16.15 ? 256 ASP B C   1 
ATOM   4226 O  O   . ASP B 1 251 ? -28.685 -7.568  15.836  1.00 16.27 ? 256 ASP B O   1 
ATOM   4227 C  CB  . ASP B 1 251 ? -26.155 -5.935  15.360  1.00 14.81 ? 256 ASP B CB  1 
ATOM   4228 C  CG  . ASP B 1 251 ? -26.320 -4.465  15.708  1.00 17.13 ? 256 ASP B CG  1 
ATOM   4229 O  OD1 . ASP B 1 251 ? -27.366 -3.880  15.364  1.00 17.18 ? 256 ASP B OD1 1 
ATOM   4230 O  OD2 . ASP B 1 251 ? -25.413 -3.932  16.371  1.00 18.53 ? 256 ASP B OD2 1 
ATOM   4231 N  N   . PRO B 1 252 ? -28.632 -6.066  17.539  1.00 16.94 ? 257 PRO B N   1 
ATOM   4232 C  CA  . PRO B 1 252 ? -30.114 -5.992  17.716  1.00 18.35 ? 257 PRO B CA  1 
ATOM   4233 C  C   . PRO B 1 252 ? -30.893 -5.645  16.449  1.00 19.43 ? 257 PRO B C   1 
ATOM   4234 O  O   . PRO B 1 252 ? -32.079 -6.035  16.332  1.00 19.99 ? 257 PRO B O   1 
ATOM   4235 C  CB  . PRO B 1 252 ? -30.305 -4.897  18.778  1.00 19.14 ? 257 PRO B CB  1 
ATOM   4236 C  CG  . PRO B 1 252 ? -28.987 -4.792  19.506  1.00 19.27 ? 257 PRO B CG  1 
ATOM   4237 C  CD  . PRO B 1 252 ? -27.904 -5.253  18.541  1.00 17.39 ? 257 PRO B CD  1 
ATOM   4238 N  N   . THR B 1 253 ? -30.262 -4.931  15.498  1.00 19.54 ? 258 THR B N   1 
ATOM   4239 C  CA  . THR B 1 253 ? -30.899 -4.662  14.204  1.00 21.19 ? 258 THR B CA  1 
ATOM   4240 C  C   . THR B 1 253 ? -31.216 -5.953  13.423  1.00 21.05 ? 258 THR B C   1 
ATOM   4241 O  O   . THR B 1 253 ? -32.112 -5.981  12.600  1.00 21.67 ? 258 THR B O   1 
ATOM   4242 C  CB  . THR B 1 253 ? -30.082 -3.700  13.319  1.00 21.30 ? 258 THR B CB  1 
ATOM   4243 O  OG1 . THR B 1 253 ? -28.816 -4.302  13.024  1.00 22.25 ? 258 THR B OG1 1 
ATOM   4244 C  CG2 . THR B 1 253 ? -29.865 -2.364  14.025  1.00 19.96 ? 258 THR B CG2 1 
ATOM   4245 N  N   . LEU B 1 254 ? -30.469 -7.014  13.688  1.00 20.32 ? 259 LEU B N   1 
ATOM   4246 C  CA  . LEU B 1 254 ? -30.585 -8.261  12.957  1.00 19.90 ? 259 LEU B CA  1 
ATOM   4247 C  C   . LEU B 1 254 ? -31.401 -9.298  13.759  1.00 20.72 ? 259 LEU B C   1 
ATOM   4248 O  O   . LEU B 1 254 ? -32.144 -10.104 13.181  1.00 21.82 ? 259 LEU B O   1 
ATOM   4249 C  CB  . LEU B 1 254 ? -29.180 -8.848  12.689  1.00 19.72 ? 259 LEU B CB  1 
ATOM   4250 C  CG  . LEU B 1 254 ? -28.205 -7.966  11.906  1.00 19.49 ? 259 LEU B CG  1 
ATOM   4251 C  CD1 . LEU B 1 254 ? -26.785 -8.530  11.988  1.00 19.01 ? 259 LEU B CD1 1 
ATOM   4252 C  CD2 . LEU B 1 254 ? -28.627 -7.779  10.430  1.00 21.35 ? 259 LEU B CD2 1 
ATOM   4253 N  N   . ALA B 1 255 ? -31.204 -9.286  15.077  1.00 19.73 ? 260 ALA B N   1 
ATOM   4254 C  CA  . ALA B 1 255 ? -31.823 -10.223 16.011  1.00 18.98 ? 260 ALA B CA  1 
ATOM   4255 C  C   . ALA B 1 255 ? -32.513 -9.427  17.126  1.00 19.08 ? 260 ALA B C   1 
ATOM   4256 O  O   . ALA B 1 255 ? -32.031 -9.400  18.290  1.00 18.62 ? 260 ALA B O   1 
ATOM   4257 C  CB  . ALA B 1 255 ? -30.758 -11.155 16.584  1.00 18.13 ? 260 ALA B CB  1 
ATOM   4258 N  N   . PRO B 1 256 ? -33.628 -8.738  16.784  1.00 19.69 ? 261 PRO B N   1 
ATOM   4259 C  CA  . PRO B 1 256 ? -34.285 -7.909  17.791  1.00 20.70 ? 261 PRO B CA  1 
ATOM   4260 C  C   . PRO B 1 256 ? -35.171 -8.691  18.775  1.00 21.08 ? 261 PRO B C   1 
ATOM   4261 O  O   . PRO B 1 256 ? -35.358 -8.248  19.916  1.00 21.54 ? 261 PRO B O   1 
ATOM   4262 C  CB  . PRO B 1 256 ? -35.125 -6.930  16.958  1.00 20.25 ? 261 PRO B CB  1 
ATOM   4263 C  CG  . PRO B 1 256 ? -35.412 -7.660  15.689  1.00 21.44 ? 261 PRO B CG  1 
ATOM   4264 C  CD  . PRO B 1 256 ? -34.189 -8.520  15.434  1.00 19.06 ? 261 PRO B CD  1 
ATOM   4265 N  N   . ALA B 1 257 ? -35.711 -9.835  18.352  1.00 21.08 ? 262 ALA B N   1 
ATOM   4266 C  CA  . ALA B 1 257 ? -36.576 -10.619 19.254  1.00 21.17 ? 262 ALA B CA  1 
ATOM   4267 C  C   . ALA B 1 257 ? -35.745 -11.457 20.251  1.00 20.74 ? 262 ALA B C   1 
ATOM   4268 O  O   . ALA B 1 257 ? -35.565 -12.667 20.075  1.00 21.18 ? 262 ALA B O   1 
ATOM   4269 C  CB  . ALA B 1 257 ? -37.573 -11.492 18.441  1.00 21.31 ? 262 ALA B CB  1 
ATOM   4270 N  N   . THR B 1 258 ? -35.241 -10.781 21.286  1.00 20.86 ? 263 THR B N   1 
ATOM   4271 C  CA  . THR B 1 258 ? -34.374 -11.371 22.318  1.00 20.01 ? 263 THR B CA  1 
ATOM   4272 C  C   . THR B 1 258 ? -34.354 -10.479 23.580  1.00 20.46 ? 263 THR B C   1 
ATOM   4273 O  O   . THR B 1 258 ? -34.567 -9.254  23.500  1.00 20.48 ? 263 THR B O   1 
ATOM   4274 C  CB  . THR B 1 258 ? -32.943 -11.565 21.773  1.00 20.05 ? 263 THR B CB  1 
ATOM   4275 O  OG1 . THR B 1 258 ? -32.232 -12.476 22.612  1.00 19.13 ? 263 THR B OG1 1 
ATOM   4276 C  CG2 . THR B 1 258 ? -32.204 -10.217 21.713  1.00 20.77 ? 263 THR B CG2 1 
ATOM   4277 N  N   . GLY B 1 259 ? -34.093 -11.084 24.732  1.00 20.97 ? 264 GLY B N   1 
ATOM   4278 C  CA  . GLY B 1 259 ? -34.295 -10.433 26.040  1.00 21.62 ? 264 GLY B CA  1 
ATOM   4279 C  C   . GLY B 1 259 ? -33.280 -9.404  26.523  1.00 22.49 ? 264 GLY B C   1 
ATOM   4280 O  O   . GLY B 1 259 ? -33.625 -8.473  27.257  1.00 22.05 ? 264 GLY B O   1 
ATOM   4281 N  N   . THR B 1 260 ? -32.017 -9.565  26.135  1.00 21.87 ? 265 THR B N   1 
ATOM   4282 C  CA  . THR B 1 260 ? -30.992 -8.650  26.596  1.00 23.03 ? 265 THR B CA  1 
ATOM   4283 C  C   . THR B 1 260 ? -30.171 -8.193  25.390  1.00 21.87 ? 265 THR B C   1 
ATOM   4284 O  O   . THR B 1 260 ? -29.027 -8.646  25.211  1.00 21.94 ? 265 THR B O   1 
ATOM   4285 C  CB  . THR B 1 260 ? -30.100 -9.315  27.645  1.00 23.07 ? 265 THR B CB  1 
ATOM   4286 O  OG1 . THR B 1 260 ? -29.481 -10.467 27.079  1.00 28.44 ? 265 THR B OG1 1 
ATOM   4287 C  CG2 . THR B 1 260 ? -30.890 -9.783  28.848  1.00 25.63 ? 265 THR B CG2 1 
ATOM   4288 N  N   . PRO B 1 261 ? -30.777 -7.356  24.524  1.00 21.04 ? 266 PRO B N   1 
ATOM   4289 C  CA  . PRO B 1 261 ? -30.111 -6.934  23.289  1.00 20.23 ? 266 PRO B CA  1 
ATOM   4290 C  C   . PRO B 1 261 ? -29.029 -5.938  23.644  1.00 20.43 ? 266 PRO B C   1 
ATOM   4291 O  O   . PRO B 1 261 ? -29.165 -5.177  24.618  1.00 20.62 ? 266 PRO B O   1 
ATOM   4292 C  CB  . PRO B 1 261 ? -31.239 -6.237  22.500  1.00 20.67 ? 266 PRO B CB  1 
ATOM   4293 C  CG  . PRO B 1 261 ? -32.176 -5.720  23.586  1.00 21.22 ? 266 PRO B CG  1 
ATOM   4294 C  CD  . PRO B 1 261 ? -32.168 -6.857  24.582  1.00 20.69 ? 266 PRO B CD  1 
ATOM   4295 N  N   . VAL B 1 262 ? -27.918 -5.985  22.924  1.00 18.59 ? 267 VAL B N   1 
ATOM   4296 C  CA  . VAL B 1 262 ? -26.813 -5.056  23.203  1.00 17.70 ? 267 VAL B CA  1 
ATOM   4297 C  C   . VAL B 1 262 ? -26.270 -4.549  21.855  1.00 16.48 ? 267 VAL B C   1 
ATOM   4298 O  O   . VAL B 1 262 ? -25.894 -5.343  20.998  1.00 16.00 ? 267 VAL B O   1 
ATOM   4299 C  CB  . VAL B 1 262 ? -25.659 -5.674  24.022  1.00 18.20 ? 267 VAL B CB  1 
ATOM   4300 C  CG1 . VAL B 1 262 ? -24.591 -4.562  24.342  1.00 19.90 ? 267 VAL B CG1 1 
ATOM   4301 C  CG2 . VAL B 1 262 ? -26.123 -6.327  25.334  1.00 16.39 ? 267 VAL B CG2 1 
ATOM   4302 N  N   . VAL B 1 263 ? -26.231 -3.227  21.688  1.00 16.49 ? 268 VAL B N   1 
ATOM   4303 C  CA  . VAL B 1 263 ? -25.883 -2.600  20.414  1.00 16.50 ? 268 VAL B CA  1 
ATOM   4304 C  C   . VAL B 1 263 ? -24.440 -2.945  20.048  1.00 15.35 ? 268 VAL B C   1 
ATOM   4305 O  O   . VAL B 1 263 ? -23.663 -3.226  20.934  1.00 15.28 ? 268 VAL B O   1 
ATOM   4306 C  CB  . VAL B 1 263 ? -26.057 -1.054  20.502  1.00 16.49 ? 268 VAL B CB  1 
ATOM   4307 C  CG1 . VAL B 1 263 ? -27.565 -0.722  20.700  1.00 19.70 ? 268 VAL B CG1 1 
ATOM   4308 C  CG2 . VAL B 1 263 ? -25.224 -0.464  21.662  1.00 19.84 ? 268 VAL B CG2 1 
ATOM   4309 N  N   . GLY B 1 264 ? -24.130 -2.930  18.755  1.00 14.94 ? 269 GLY B N   1 
ATOM   4310 C  CA  . GLY B 1 264 ? -22.741 -3.145  18.237  1.00 14.52 ? 269 GLY B CA  1 
ATOM   4311 C  C   . GLY B 1 264 ? -22.292 -4.600  18.206  1.00 13.11 ? 269 GLY B C   1 
ATOM   4312 O  O   . GLY B 1 264 ? -21.156 -4.920  18.575  1.00 13.72 ? 269 GLY B O   1 
ATOM   4313 N  N   . GLY B 1 265 ? -23.185 -5.480  17.767  1.00 13.93 ? 270 GLY B N   1 
ATOM   4314 C  CA  . GLY B 1 265 ? -22.901 -6.927  17.730  1.00 13.15 ? 270 GLY B CA  1 
ATOM   4315 C  C   . GLY B 1 265 ? -22.394 -7.426  16.399  1.00 12.92 ? 270 GLY B C   1 
ATOM   4316 O  O   . GLY B 1 265 ? -22.054 -6.630  15.506  1.00 12.61 ? 270 GLY B O   1 
ATOM   4317 N  N   . LEU B 1 266 ? -22.348 -8.748  16.257  1.00 12.25 ? 271 LEU B N   1 
ATOM   4318 C  CA  . LEU B 1 266 ? -21.929 -9.361  15.001  1.00 12.90 ? 271 LEU B CA  1 
ATOM   4319 C  C   . LEU B 1 266 ? -22.838 -8.961  13.868  1.00 14.31 ? 271 LEU B C   1 
ATOM   4320 O  O   . LEU B 1 266 ? -24.054 -8.826  14.051  1.00 14.16 ? 271 LEU B O   1 
ATOM   4321 C  CB  . LEU B 1 266 ? -21.980 -10.897 15.091  1.00 12.26 ? 271 LEU B CB  1 
ATOM   4322 C  CG  . LEU B 1 266 ? -21.179 -11.558 16.212  1.00 13.46 ? 271 LEU B CG  1 
ATOM   4323 C  CD1 . LEU B 1 266 ? -21.638 -13.024 16.335  1.00 14.85 ? 271 LEU B CD1 1 
ATOM   4324 C  CD2 . LEU B 1 266 ? -19.678 -11.456 15.962  1.00 12.69 ? 271 LEU B CD2 1 
ATOM   4325 N  N   . THR B 1 267 ? -22.248 -8.834  12.690  1.00 13.71 ? 272 THR B N   1 
ATOM   4326 C  CA  . THR B 1 267 ? -23.015 -8.743  11.443  1.00 13.69 ? 272 THR B CA  1 
ATOM   4327 C  C   . THR B 1 267 ? -23.499 -10.121 11.028  1.00 13.35 ? 272 THR B C   1 
ATOM   4328 O  O   . THR B 1 267 ? -23.007 -11.123 11.532  1.00 12.48 ? 272 THR B O   1 
ATOM   4329 C  CB  . THR B 1 267 ? -22.175 -8.192  10.308  1.00 13.28 ? 272 THR B CB  1 
ATOM   4330 O  OG1 . THR B 1 267 ? -21.131 -9.122  9.999   1.00 11.54 ? 272 THR B OG1 1 
ATOM   4331 C  CG2 . THR B 1 267 ? -21.571 -6.804  10.709  1.00 14.51 ? 272 THR B CG2 1 
ATOM   4332 N  N   . TYR B 1 268 ? -24.473 -10.154 10.123  1.00 13.53 ? 273 TYR B N   1 
ATOM   4333 C  CA  . TYR B 1 268 ? -24.951 -11.393 9.542   1.00 13.77 ? 273 TYR B CA  1 
ATOM   4334 C  C   . TYR B 1 268 ? -23.762 -12.195 9.010   1.00 14.11 ? 273 TYR B C   1 
ATOM   4335 O  O   . TYR B 1 268 ? -23.635 -13.405 9.264   1.00 13.37 ? 273 TYR B O   1 
ATOM   4336 C  CB  . TYR B 1 268 ? -25.900 -11.105 8.376   1.00 14.67 ? 273 TYR B CB  1 
ATOM   4337 C  CG  . TYR B 1 268 ? -26.425 -12.357 7.771   1.00 15.70 ? 273 TYR B CG  1 
ATOM   4338 C  CD1 . TYR B 1 268 ? -27.595 -12.965 8.284   1.00 15.98 ? 273 TYR B CD1 1 
ATOM   4339 C  CD2 . TYR B 1 268 ? -25.761 -12.964 6.701   1.00 17.66 ? 273 TYR B CD2 1 
ATOM   4340 C  CE1 . TYR B 1 268 ? -28.084 -14.154 7.729   1.00 17.80 ? 273 TYR B CE1 1 
ATOM   4341 C  CE2 . TYR B 1 268 ? -26.237 -14.159 6.144   1.00 19.11 ? 273 TYR B CE2 1 
ATOM   4342 C  CZ  . TYR B 1 268 ? -27.412 -14.734 6.668   1.00 18.49 ? 273 TYR B CZ  1 
ATOM   4343 O  OH  . TYR B 1 268 ? -27.841 -15.905 6.112   1.00 19.19 ? 273 TYR B OH  1 
ATOM   4344 N  N   . ARG B 1 269 ? -22.911 -11.507 8.259   1.00 12.83 ? 274 ARG B N   1 
ATOM   4345 C  CA  . ARG B 1 269 ? -21.756 -12.152 7.643   1.00 13.14 ? 274 ARG B CA  1 
ATOM   4346 C  C   . ARG B 1 269 ? -20.788 -12.765 8.640   1.00 12.63 ? 274 ARG B C   1 
ATOM   4347 O  O   . ARG B 1 269 ? -20.297 -13.876 8.448   1.00 11.80 ? 274 ARG B O   1 
ATOM   4348 C  CB  . ARG B 1 269 ? -21.044 -11.139 6.732   1.00 11.64 ? 274 ARG B CB  1 
ATOM   4349 C  CG  . ARG B 1 269 ? -21.861 -10.943 5.424   1.00 11.70 ? 274 ARG B CG  1 
ATOM   4350 C  CD  . ARG B 1 269 ? -21.605 -9.584  4.724   1.00 11.31 ? 274 ARG B CD  1 
ATOM   4351 N  NE  . ARG B 1 269 ? -20.162 -9.411  4.473   1.00 14.28 ? 274 ARG B NE  1 
ATOM   4352 C  CZ  . ARG B 1 269 ? -19.612 -8.336  3.919   1.00 13.01 ? 274 ARG B CZ  1 
ATOM   4353 N  NH1 . ARG B 1 269 ? -20.369 -7.306  3.559   1.00 12.21 ? 274 ARG B NH1 1 
ATOM   4354 N  NH2 . ARG B 1 269 ? -18.285 -8.310  3.740   1.00 10.56 ? 274 ARG B NH2 1 
ATOM   4355 N  N   . GLU B 1 270 ? -20.484 -12.023 9.702   1.00 13.19 ? 275 GLU B N   1 
ATOM   4356 C  CA  . GLU B 1 270 ? -19.563 -12.538 10.735  1.00 12.92 ? 275 GLU B CA  1 
ATOM   4357 C  C   . GLU B 1 270 ? -20.128 -13.811 11.383  1.00 13.46 ? 275 GLU B C   1 
ATOM   4358 O  O   . GLU B 1 270 ? -19.409 -14.771 11.669  1.00 11.68 ? 275 GLU B O   1 
ATOM   4359 C  CB  . GLU B 1 270 ? -19.331 -11.463 11.802  1.00 13.27 ? 275 GLU B CB  1 
ATOM   4360 C  CG  . GLU B 1 270 ? -18.366 -10.397 11.308  1.00 12.91 ? 275 GLU B CG  1 
ATOM   4361 C  CD  . GLU B 1 270 ? -18.295 -9.193  12.205  1.00 13.33 ? 275 GLU B CD  1 
ATOM   4362 O  OE1 . GLU B 1 270 ? -19.263 -8.949  12.965  1.00 13.55 ? 275 GLU B OE1 1 
ATOM   4363 O  OE2 . GLU B 1 270 ? -17.268 -8.486  12.135  1.00 11.78 ? 275 GLU B OE2 1 
ATOM   4364 N  N   . GLY B 1 271 ? -21.425 -13.800 11.644  1.00 13.81 ? 276 GLY B N   1 
ATOM   4365 C  CA  . GLY B 1 271 ? -22.023 -14.958 12.317  1.00 13.98 ? 276 GLY B CA  1 
ATOM   4366 C  C   . GLY B 1 271 ? -22.049 -16.170 11.416  1.00 14.34 ? 276 GLY B C   1 
ATOM   4367 O  O   . GLY B 1 271 ? -21.862 -17.274 11.894  1.00 14.55 ? 276 GLY B O   1 
ATOM   4368 N  N   . MET B 1 272 ? -22.349 -15.976 10.130  1.00 13.80 ? 277 MET B N   1 
ATOM   4369 C  CA  . MET B 1 272 ? -22.312 -17.081 9.164   1.00 14.56 ? 277 MET B CA  1 
ATOM   4370 C  C   . MET B 1 272 ? -20.890 -17.615 9.085   1.00 14.72 ? 277 MET B C   1 
ATOM   4371 O  O   . MET B 1 272 ? -20.662 -18.829 9.044   1.00 15.31 ? 277 MET B O   1 
ATOM   4372 C  CB  . MET B 1 272 ? -22.749 -16.614 7.778   1.00 14.80 ? 277 MET B CB  1 
ATOM   4373 C  CG  . MET B 1 272 ? -24.256 -16.382 7.605   1.00 16.54 ? 277 MET B CG  1 
ATOM   4374 S  SD  . MET B 1 272 ? -25.330 -17.605 8.380   1.00 21.32 ? 277 MET B SD  1 
ATOM   4375 C  CE  . MET B 1 272 ? -25.959 -16.712 9.821   1.00 18.88 ? 277 MET B CE  1 
ATOM   4376 N  N   . TYR B 1 273 ? -19.928 -16.709 9.094   1.00 14.07 ? 278 TYR B N   1 
ATOM   4377 C  CA  . TYR B 1 273 ? -18.496 -17.104 9.028   1.00 14.02 ? 278 TYR B CA  1 
ATOM   4378 C  C   . TYR B 1 273 ? -18.049 -18.017 10.199  1.00 14.93 ? 278 TYR B C   1 
ATOM   4379 O  O   . TYR B 1 273 ? -17.312 -19.015 10.016  1.00 15.11 ? 278 TYR B O   1 
ATOM   4380 C  CB  . TYR B 1 273 ? -17.589 -15.849 8.905   1.00 13.98 ? 278 TYR B CB  1 
ATOM   4381 C  CG  . TYR B 1 273 ? -16.179 -16.254 8.566   1.00 14.76 ? 278 TYR B CG  1 
ATOM   4382 C  CD1 . TYR B 1 273 ? -15.772 -16.398 7.242   1.00 18.18 ? 278 TYR B CD1 1 
ATOM   4383 C  CD2 . TYR B 1 273 ? -15.280 -16.579 9.561   1.00 19.15 ? 278 TYR B CD2 1 
ATOM   4384 C  CE1 . TYR B 1 273 ? -14.491 -16.837 6.923   1.00 20.11 ? 278 TYR B CE1 1 
ATOM   4385 C  CE2 . TYR B 1 273 ? -14.000 -17.008 9.249   1.00 19.28 ? 278 TYR B CE2 1 
ATOM   4386 C  CZ  . TYR B 1 273 ? -13.619 -17.144 7.943   1.00 18.46 ? 278 TYR B CZ  1 
ATOM   4387 O  OH  . TYR B 1 273 ? -12.344 -17.573 7.671   1.00 22.12 ? 278 TYR B OH  1 
ATOM   4388 N  N   . ILE B 1 274 ? -18.418 -17.632 11.424  1.00 14.20 ? 279 ILE B N   1 
ATOM   4389 C  CA  . ILE B 1 274 ? -18.231 -18.500 12.604  1.00 12.82 ? 279 ILE B CA  1 
ATOM   4390 C  C   . ILE B 1 274 ? -18.858 -19.889 12.385  1.00 13.05 ? 279 ILE B C   1 
ATOM   4391 O  O   . ILE B 1 274 ? -18.202 -20.914 12.562  1.00 13.53 ? 279 ILE B O   1 
ATOM   4392 C  CB  . ILE B 1 274 ? -18.861 -17.855 13.876  1.00 12.74 ? 279 ILE B CB  1 
ATOM   4393 C  CG1 . ILE B 1 274 ? -18.181 -16.529 14.206  1.00 13.65 ? 279 ILE B CG1 1 
ATOM   4394 C  CG2 . ILE B 1 274 ? -18.807 -18.844 15.071  1.00 13.99 ? 279 ILE B CG2 1 
ATOM   4395 C  CD1 . ILE B 1 274 ? -18.966 -15.655 15.266  1.00 12.38 ? 279 ILE B CD1 1 
ATOM   4396 N  N   . ALA B 1 275 ? -20.127 -19.935 12.013  1.00 13.05 ? 280 ALA B N   1 
ATOM   4397 C  CA  . ALA B 1 275 ? -20.808 -21.235 11.787  1.00 14.83 ? 280 ALA B CA  1 
ATOM   4398 C  C   . ALA B 1 275 ? -20.095 -22.082 10.719  1.00 15.11 ? 280 ALA B C   1 
ATOM   4399 O  O   . ALA B 1 275 ? -19.819 -23.305 10.907  1.00 14.85 ? 280 ALA B O   1 
ATOM   4400 C  CB  . ALA B 1 275 ? -22.279 -20.999 11.365  1.00 13.66 ? 280 ALA B CB  1 
ATOM   4401 N  N   . GLU B 1 276 ? -19.763 -21.419 9.605   1.00 15.18 ? 281 GLU B N   1 
ATOM   4402 C  CA  . GLU B 1 276 ? -19.039 -22.090 8.522   1.00 15.66 ? 281 GLU B CA  1 
ATOM   4403 C  C   . GLU B 1 276 ? -17.702 -22.663 8.953   1.00 15.64 ? 281 GLU B C   1 
ATOM   4404 O  O   . GLU B 1 276 ? -17.399 -23.820 8.622   1.00 17.59 ? 281 GLU B O   1 
ATOM   4405 C  CB  . GLU B 1 276 ? -18.787 -21.097 7.382   1.00 15.54 ? 281 GLU B CB  1 
ATOM   4406 C  CG  . GLU B 1 276 ? -20.018 -20.722 6.649   1.00 12.50 ? 281 GLU B CG  1 
ATOM   4407 C  CD  . GLU B 1 276 ? -19.752 -19.505 5.726   1.00 14.32 ? 281 GLU B CD  1 
ATOM   4408 O  OE1 . GLU B 1 276 ? -18.665 -18.863 5.820   1.00 18.17 ? 281 GLU B OE1 1 
ATOM   4409 O  OE2 . GLU B 1 276 ? -20.639 -19.197 4.923   1.00 16.43 ? 281 GLU B OE2 1 
ATOM   4410 N  N   . GLU B 1 277 ? -16.902 -21.877 9.663   1.00 15.39 ? 282 GLU B N   1 
ATOM   4411 C  CA  . GLU B 1 277 ? -15.631 -22.362 10.219  1.00 15.86 ? 282 GLU B CA  1 
ATOM   4412 C  C   . GLU B 1 277 ? -15.840 -23.534 11.193  1.00 16.98 ? 282 GLU B C   1 
ATOM   4413 O  O   . GLU B 1 277 ? -15.126 -24.540 11.108  1.00 16.77 ? 282 GLU B O   1 
ATOM   4414 C  CB  . GLU B 1 277 ? -14.813 -21.246 10.863  1.00 16.61 ? 282 GLU B CB  1 
ATOM   4415 C  CG  . GLU B 1 277 ? -14.200 -20.299 9.825   1.00 17.62 ? 282 GLU B CG  1 
ATOM   4416 C  CD  . GLU B 1 277 ? -13.477 -21.066 8.714   1.00 19.71 ? 282 GLU B CD  1 
ATOM   4417 O  OE1 . GLU B 1 277 ? -12.395 -21.639 8.986   1.00 22.49 ? 282 GLU B OE1 1 
ATOM   4418 O  OE2 . GLU B 1 277 ? -14.027 -21.138 7.610   1.00 20.79 ? 282 GLU B OE2 1 
ATOM   4419 N  N   . ILE B 1 278 ? -16.830 -23.415 12.078  1.00 16.10 ? 283 ILE B N   1 
ATOM   4420 C  CA  . ILE B 1 278 ? -17.224 -24.544 12.944  1.00 17.78 ? 283 ILE B CA  1 
ATOM   4421 C  C   . ILE B 1 278 ? -17.536 -25.803 12.094  1.00 17.12 ? 283 ILE B C   1 
ATOM   4422 O  O   . ILE B 1 278 ? -17.019 -26.895 12.359  1.00 18.71 ? 283 ILE B O   1 
ATOM   4423 C  CB  . ILE B 1 278 ? -18.450 -24.211 13.840  1.00 16.65 ? 283 ILE B CB  1 
ATOM   4424 C  CG1 . ILE B 1 278 ? -18.151 -23.090 14.847  1.00 18.99 ? 283 ILE B CG1 1 
ATOM   4425 C  CG2 . ILE B 1 278 ? -19.036 -25.485 14.503  1.00 19.05 ? 283 ILE B CG2 1 
ATOM   4426 C  CD1 . ILE B 1 278 ? -17.411 -23.491 16.103  1.00 25.42 ? 283 ILE B CD1 1 
ATOM   4427 N  N   . HIS B 1 279 ? -18.347 -25.647 11.067  1.00 18.79 ? 284 HIS B N   1 
ATOM   4428 C  CA  . HIS B 1 279 ? -18.664 -26.779 10.170  1.00 20.04 ? 284 HIS B CA  1 
ATOM   4429 C  C   . HIS B 1 279 ? -17.419 -27.374 9.531   1.00 20.82 ? 284 HIS B C   1 
ATOM   4430 O  O   . HIS B 1 279 ? -17.217 -28.616 9.513   1.00 20.80 ? 284 HIS B O   1 
ATOM   4431 C  CB  . HIS B 1 279 ? -19.627 -26.392 9.068   1.00 19.85 ? 284 HIS B CB  1 
ATOM   4432 C  CG  . HIS B 1 279 ? -19.734 -27.438 8.007   1.00 21.14 ? 284 HIS B CG  1 
ATOM   4433 N  ND1 . HIS B 1 279 ? -20.393 -28.632 8.210   1.00 24.44 ? 284 HIS B ND1 1 
ATOM   4434 C  CD2 . HIS B 1 279 ? -19.200 -27.508 6.764   1.00 22.30 ? 284 HIS B CD2 1 
ATOM   4435 C  CE1 . HIS B 1 279 ? -20.288 -29.382 7.125   1.00 22.15 ? 284 HIS B CE1 1 
ATOM   4436 N  NE2 . HIS B 1 279 ? -19.564 -28.725 6.235   1.00 23.46 ? 284 HIS B NE2 1 
ATOM   4437 N  N   . ASN B 1 280 ? -16.579 -26.490 9.017   1.00 21.19 ? 285 ASN B N   1 
ATOM   4438 C  CA  . ASN B 1 280 ? -15.359 -26.901 8.329   1.00 21.62 ? 285 ASN B CA  1 
ATOM   4439 C  C   . ASN B 1 280 ? -14.392 -27.726 9.186   1.00 22.13 ? 285 ASN B C   1 
ATOM   4440 O  O   . ASN B 1 280 ? -13.519 -28.415 8.651   1.00 21.75 ? 285 ASN B O   1 
ATOM   4441 C  CB  . ASN B 1 280 ? -14.667 -25.687 7.692   1.00 22.30 ? 285 ASN B CB  1 
ATOM   4442 C  CG  . ASN B 1 280 ? -15.451 -25.125 6.485   1.00 22.61 ? 285 ASN B CG  1 
ATOM   4443 O  OD1 . ASN B 1 280 ? -16.412 -25.729 6.003   1.00 26.08 ? 285 ASN B OD1 1 
ATOM   4444 N  ND2 . ASN B 1 280 ? -15.065 -23.938 6.034   1.00 21.88 ? 285 ASN B ND2 1 
ATOM   4445 N  N   . THR B 1 281 ? -14.532 -27.677 10.510  1.00 21.49 ? 286 THR B N   1 
ATOM   4446 C  CA  . THR B 1 281 ? -13.695 -28.547 11.356  1.00 21.64 ? 286 THR B CA  1 
ATOM   4447 C  C   . THR B 1 281 ? -14.095 -30.017 11.213  1.00 20.73 ? 286 THR B C   1 
ATOM   4448 O  O   . THR B 1 281 ? -13.248 -30.885 11.335  1.00 22.25 ? 286 THR B O   1 
ATOM   4449 C  CB  . THR B 1 281 ? -13.706 -28.173 12.861  1.00 21.32 ? 286 THR B CB  1 
ATOM   4450 O  OG1 . THR B 1 281 ? -15.005 -28.439 13.400  1.00 20.10 ? 286 THR B OG1 1 
ATOM   4451 C  CG2 . THR B 1 281 ? -13.362 -26.703 13.078  1.00 21.53 ? 286 THR B CG2 1 
ATOM   4452 N  N   . GLY B 1 282 ? -15.372 -30.274 10.936  1.00 20.92 ? 287 GLY B N   1 
ATOM   4453 C  CA  . GLY B 1 282 ? -15.973 -31.618 10.964  1.00 20.62 ? 287 GLY B CA  1 
ATOM   4454 C  C   . GLY B 1 282 ? -16.027 -32.146 12.399  1.00 20.72 ? 287 GLY B C   1 
ATOM   4455 O  O   . GLY B 1 282 ? -16.021 -33.351 12.631  1.00 19.95 ? 287 GLY B O   1 
ATOM   4456 N  N   . LEU B 1 283 ? -16.055 -31.236 13.370  1.00 20.23 ? 288 LEU B N   1 
ATOM   4457 C  CA  . LEU B 1 283 ? -16.058 -31.638 14.772  1.00 21.21 ? 288 LEU B CA  1 
ATOM   4458 C  C   . LEU B 1 283 ? -17.301 -31.231 15.539  1.00 21.30 ? 288 LEU B C   1 
ATOM   4459 O  O   . LEU B 1 283 ? -17.426 -31.566 16.720  1.00 23.06 ? 288 LEU B O   1 
ATOM   4460 C  CB  . LEU B 1 283 ? -14.773 -31.178 15.472  1.00 19.92 ? 288 LEU B CB  1 
ATOM   4461 C  CG  . LEU B 1 283 ? -13.435 -31.766 15.000  1.00 21.45 ? 288 LEU B CG  1 
ATOM   4462 C  CD1 . LEU B 1 283 ? -12.272 -30.966 15.559  1.00 22.31 ? 288 LEU B CD1 1 
ATOM   4463 C  CD2 . LEU B 1 283 ? -13.260 -33.254 15.354  1.00 21.49 ? 288 LEU B CD2 1 
ATOM   4464 N  N   . LEU B 1 284 ? -18.266 -30.592 14.886  1.00 20.81 ? 289 LEU B N   1 
ATOM   4465 C  CA  . LEU B 1 284 ? -19.411 -30.114 15.649  1.00 21.25 ? 289 LEU B CA  1 
ATOM   4466 C  C   . LEU B 1 284 ? -20.267 -31.286 16.171  1.00 22.21 ? 289 LEU B C   1 
ATOM   4467 O  O   . LEU B 1 284 ? -20.756 -32.092 15.380  1.00 21.78 ? 289 LEU B O   1 
ATOM   4468 C  CB  . LEU B 1 284 ? -20.247 -29.128 14.857  1.00 21.48 ? 289 LEU B CB  1 
ATOM   4469 C  CG  . LEU B 1 284 ? -21.480 -28.600 15.564  1.00 20.88 ? 289 LEU B CG  1 
ATOM   4470 C  CD1 . LEU B 1 284 ? -21.075 -27.701 16.748  1.00 22.53 ? 289 LEU B CD1 1 
ATOM   4471 C  CD2 . LEU B 1 284 ? -22.347 -27.871 14.579  1.00 18.61 ? 289 LEU B CD2 1 
ATOM   4472 N  N   . SER B 1 285 ? -20.415 -31.368 17.498  1.00 22.32 ? 290 SER B N   1 
ATOM   4473 C  CA  A SER B 1 285 ? -21.105 -32.497 18.146  0.50 22.54 ? 290 SER B CA  1 
ATOM   4474 C  CA  B SER B 1 285 ? -21.114 -32.498 18.134  0.50 22.39 ? 290 SER B CA  1 
ATOM   4475 C  C   . SER B 1 285 ? -22.424 -32.078 18.794  1.00 21.81 ? 290 SER B C   1 
ATOM   4476 O  O   . SER B 1 285 ? -23.356 -32.890 18.961  1.00 21.89 ? 290 SER B O   1 
ATOM   4477 C  CB  A SER B 1 285 ? -20.192 -33.113 19.196  0.50 22.81 ? 290 SER B CB  1 
ATOM   4478 C  CB  B SER B 1 285 ? -20.199 -33.184 19.148  0.50 22.62 ? 290 SER B CB  1 
ATOM   4479 O  OG  A SER B 1 285 ? -18.872 -32.620 19.051  0.50 23.61 ? 290 SER B OG  1 
ATOM   4480 O  OG  B SER B 1 285 ? -20.869 -34.232 19.827  0.50 22.50 ? 290 SER B OG  1 
ATOM   4481 N  N   . ALA B 1 286 ? -22.509 -30.808 19.167  1.00 20.87 ? 291 ALA B N   1 
ATOM   4482 C  CA  . ALA B 1 286 ? -23.694 -30.303 19.813  1.00 20.20 ? 291 ALA B CA  1 
ATOM   4483 C  C   . ALA B 1 286 ? -23.679 -28.798 19.658  1.00 19.52 ? 291 ALA B C   1 
ATOM   4484 O  O   . ALA B 1 286 ? -22.599 -28.189 19.612  1.00 19.23 ? 291 ALA B O   1 
ATOM   4485 C  CB  . ALA B 1 286 ? -23.705 -30.698 21.300  1.00 19.12 ? 291 ALA B CB  1 
ATOM   4486 N  N   . LEU B 1 287 ? -24.878 -28.244 19.559  1.00 19.28 ? 292 LEU B N   1 
ATOM   4487 C  CA  . LEU B 1 287 ? -25.093 -26.834 19.260  1.00 19.41 ? 292 LEU B CA  1 
ATOM   4488 C  C   . LEU B 1 287 ? -26.301 -26.351 20.042  1.00 19.82 ? 292 LEU B C   1 
ATOM   4489 O  O   . LEU B 1 287 ? -27.356 -26.996 20.002  1.00 19.81 ? 292 LEU B O   1 
ATOM   4490 C  CB  . LEU B 1 287 ? -25.372 -26.661 17.758  1.00 18.70 ? 292 LEU B CB  1 
ATOM   4491 C  CG  . LEU B 1 287 ? -25.576 -25.247 17.179  1.00 20.46 ? 292 LEU B CG  1 
ATOM   4492 C  CD1 . LEU B 1 287 ? -25.202 -25.214 15.666  1.00 21.96 ? 292 LEU B CD1 1 
ATOM   4493 C  CD2 . LEU B 1 287 ? -26.997 -24.748 17.312  1.00 20.49 ? 292 LEU B CD2 1 
ATOM   4494 N  N   . ASP B 1 288 ? -26.166 -25.207 20.726  1.00 19.70 ? 293 ASP B N   1 
ATOM   4495 C  CA  . ASP B 1 288 ? -27.314 -24.564 21.350  1.00 19.81 ? 293 ASP B CA  1 
ATOM   4496 C  C   . ASP B 1 288 ? -27.623 -23.327 20.536  1.00 20.41 ? 293 ASP B C   1 
ATOM   4497 O  O   . ASP B 1 288 ? -26.709 -22.574 20.159  1.00 20.80 ? 293 ASP B O   1 
ATOM   4498 C  CB  . ASP B 1 288 ? -26.995 -24.122 22.793  1.00 19.67 ? 293 ASP B CB  1 
ATOM   4499 C  CG  . ASP B 1 288 ? -26.315 -25.197 23.598  1.00 20.21 ? 293 ASP B CG  1 
ATOM   4500 O  OD1 . ASP B 1 288 ? -26.738 -26.373 23.490  1.00 20.96 ? 293 ASP B OD1 1 
ATOM   4501 O  OD2 . ASP B 1 288 ? -25.373 -24.875 24.362  1.00 21.21 ? 293 ASP B OD2 1 
ATOM   4502 N  N   . LEU B 1 289 ? -28.892 -23.130 20.235  1.00 19.53 ? 294 LEU B N   1 
ATOM   4503 C  CA  . LEU B 1 289 ? -29.311 -21.870 19.674  1.00 19.36 ? 294 LEU B CA  1 
ATOM   4504 C  C   . LEU B 1 289 ? -30.326 -21.312 20.652  1.00 19.15 ? 294 LEU B C   1 
ATOM   4505 O  O   . LEU B 1 289 ? -31.468 -21.791 20.731  1.00 18.35 ? 294 LEU B O   1 
ATOM   4506 C  CB  . LEU B 1 289 ? -29.899 -22.027 18.269  1.00 18.88 ? 294 LEU B CB  1 
ATOM   4507 C  CG  . LEU B 1 289 ? -29.938 -20.760 17.389  1.00 19.18 ? 294 LEU B CG  1 
ATOM   4508 C  CD1 . LEU B 1 289 ? -30.832 -19.629 17.960  1.00 19.14 ? 294 LEU B CD1 1 
ATOM   4509 C  CD2 . LEU B 1 289 ? -28.499 -20.252 17.132  1.00 18.20 ? 294 LEU B CD2 1 
ATOM   4510 N  N   . VAL B 1 290 ? -29.897 -20.293 21.399  1.00 18.67 ? 295 VAL B N   1 
ATOM   4511 C  CA  . VAL B 1 290 ? -30.689 -19.835 22.555  1.00 18.96 ? 295 VAL B CA  1 
ATOM   4512 C  C   . VAL B 1 290 ? -31.155 -18.393 22.426  1.00 19.35 ? 295 VAL B C   1 
ATOM   4513 O  O   . VAL B 1 290 ? -30.619 -17.623 21.621  1.00 18.03 ? 295 VAL B O   1 
ATOM   4514 C  CB  . VAL B 1 290 ? -29.920 -20.038 23.895  1.00 18.61 ? 295 VAL B CB  1 
ATOM   4515 C  CG1 . VAL B 1 290 ? -29.573 -21.519 24.123  1.00 20.45 ? 295 VAL B CG1 1 
ATOM   4516 C  CG2 . VAL B 1 290 ? -28.644 -19.206 23.930  1.00 18.59 ? 295 VAL B CG2 1 
ATOM   4517 N  N   . GLU B 1 291 ? -32.176 -18.061 23.222  1.00 19.22 ? 296 GLU B N   1 
ATOM   4518 C  CA  . GLU B 1 291 ? -32.654 -16.691 23.492  1.00 19.70 ? 296 GLU B CA  1 
ATOM   4519 C  C   . GLU B 1 291 ? -33.550 -16.015 22.449  1.00 19.96 ? 296 GLU B C   1 
ATOM   4520 O  O   . GLU B 1 291 ? -33.798 -14.809 22.543  1.00 19.99 ? 296 GLU B O   1 
ATOM   4521 C  CB  . GLU B 1 291 ? -31.518 -15.749 23.962  1.00 20.06 ? 296 GLU B CB  1 
ATOM   4522 C  CG  . GLU B 1 291 ? -30.778 -16.202 25.230  1.00 20.10 ? 296 GLU B CG  1 
ATOM   4523 C  CD  . GLU B 1 291 ? -31.581 -15.957 26.555  1.00 20.91 ? 296 GLU B CD  1 
ATOM   4524 O  OE1 . GLU B 1 291 ? -32.690 -15.387 26.509  1.00 21.03 ? 296 GLU B OE1 1 
ATOM   4525 O  OE2 . GLU B 1 291 ? -31.074 -16.316 27.644  1.00 18.93 ? 296 GLU B OE2 1 
ATOM   4526 N  N   . VAL B 1 292 ? -34.032 -16.773 21.465  1.00 19.95 ? 297 VAL B N   1 
ATOM   4527 C  CA  . VAL B 1 292 ? -35.032 -16.271 20.557  1.00 21.06 ? 297 VAL B CA  1 
ATOM   4528 C  C   . VAL B 1 292 ? -36.342 -16.187 21.352  1.00 22.25 ? 297 VAL B C   1 
ATOM   4529 O  O   . VAL B 1 292 ? -36.832 -17.217 21.851  1.00 22.32 ? 297 VAL B O   1 
ATOM   4530 C  CB  . VAL B 1 292 ? -35.183 -17.154 19.305  1.00 21.29 ? 297 VAL B CB  1 
ATOM   4531 C  CG1 . VAL B 1 292 ? -36.367 -16.704 18.497  1.00 21.58 ? 297 VAL B CG1 1 
ATOM   4532 C  CG2 . VAL B 1 292 ? -33.910 -17.103 18.446  1.00 19.71 ? 297 VAL B CG2 1 
ATOM   4533 N  N   . ASN B 1 293 ? -36.828 -14.955 21.515  1.00 23.20 ? 298 ASN B N   1 
ATOM   4534 C  CA  . ASN B 1 293 ? -38.119 -14.638 22.172  1.00 24.99 ? 298 ASN B CA  1 
ATOM   4535 C  C   . ASN B 1 293 ? -39.058 -13.888 21.236  1.00 25.55 ? 298 ASN B C   1 
ATOM   4536 O  O   . ASN B 1 293 ? -38.997 -12.671 21.164  1.00 26.14 ? 298 ASN B O   1 
ATOM   4537 C  CB  . ASN B 1 293 ? -37.886 -13.802 23.433  1.00 24.09 ? 298 ASN B CB  1 
ATOM   4538 C  CG  . ASN B 1 293 ? -39.139 -13.658 24.289  1.00 25.11 ? 298 ASN B CG  1 
ATOM   4539 O  OD1 . ASN B 1 293 ? -40.264 -13.748 23.792  1.00 20.78 ? 298 ASN B OD1 1 
ATOM   4540 N  ND2 . ASN B 1 293 ? -38.937 -13.467 25.592  1.00 24.90 ? 298 ASN B ND2 1 
ATOM   4541 N  N   . PRO B 1 294 ? -39.922 -14.608 20.510  1.00 26.89 ? 299 PRO B N   1 
ATOM   4542 C  CA  . PRO B 1 294 ? -40.793 -13.960 19.521  1.00 28.57 ? 299 PRO B CA  1 
ATOM   4543 C  C   . PRO B 1 294 ? -41.694 -12.860 20.112  1.00 29.86 ? 299 PRO B C   1 
ATOM   4544 O  O   . PRO B 1 294 ? -41.968 -11.855 19.441  1.00 30.47 ? 299 PRO B O   1 
ATOM   4545 C  CB  . PRO B 1 294 ? -41.619 -15.113 18.925  1.00 28.47 ? 299 PRO B CB  1 
ATOM   4546 C  CG  . PRO B 1 294 ? -41.358 -16.298 19.761  1.00 28.51 ? 299 PRO B CG  1 
ATOM   4547 C  CD  . PRO B 1 294 ? -40.132 -16.065 20.598  1.00 27.31 ? 299 PRO B CD  1 
ATOM   4548 N  N   . GLN B 1 295 ? -42.081 -13.008 21.372  1.00 31.73 ? 300 GLN B N   1 
ATOM   4549 C  CA  . GLN B 1 295 ? -42.962 -12.017 22.004  1.00 33.53 ? 300 GLN B CA  1 
ATOM   4550 C  C   . GLN B 1 295 ? -42.319 -10.637 22.203  1.00 33.92 ? 300 GLN B C   1 
ATOM   4551 O  O   . GLN B 1 295 ? -43.035 -9.635  22.277  1.00 33.82 ? 300 GLN B O   1 
ATOM   4552 C  CB  . GLN B 1 295 ? -43.562 -12.566 23.305  1.00 33.83 ? 300 GLN B CB  1 
ATOM   4553 C  CG  . GLN B 1 295 ? -44.321 -13.877 23.104  1.00 36.58 ? 300 GLN B CG  1 
ATOM   4554 C  CD  . GLN B 1 295 ? -45.110 -14.332 24.333  1.00 40.66 ? 300 GLN B CD  1 
ATOM   4555 O  OE1 . GLN B 1 295 ? -45.099 -13.678 25.386  1.00 43.28 ? 300 GLN B OE1 1 
ATOM   4556 N  NE2 . GLN B 1 295 ? -45.809 -15.463 24.198  1.00 41.77 ? 300 GLN B NE2 1 
ATOM   4557 N  N   . LEU B 1 296 ? -40.982 -10.571 22.256  1.00 34.58 ? 301 LEU B N   1 
ATOM   4558 C  CA  . LEU B 1 296 ? -40.303 -9.287  22.466  1.00 35.13 ? 301 LEU B CA  1 
ATOM   4559 C  C   . LEU B 1 296 ? -40.194 -8.425  21.213  1.00 35.93 ? 301 LEU B C   1 
ATOM   4560 O  O   . LEU B 1 296 ? -39.854 -7.232  21.293  1.00 35.90 ? 301 LEU B O   1 
ATOM   4561 C  CB  . LEU B 1 296 ? -38.932 -9.468  23.126  1.00 35.29 ? 301 LEU B CB  1 
ATOM   4562 C  CG  . LEU B 1 296 ? -38.947 -10.119 24.508  1.00 34.77 ? 301 LEU B CG  1 
ATOM   4563 C  CD1 . LEU B 1 296 ? -37.566 -10.237 25.043  1.00 34.12 ? 301 LEU B CD1 1 
ATOM   4564 C  CD2 . LEU B 1 296 ? -39.844 -9.348  25.503  1.00 36.10 ? 301 LEU B CD2 1 
ATOM   4565 N  N   . ALA B 1 297 ? -40.491 -9.024  20.063  1.00 36.79 ? 302 ALA B N   1 
ATOM   4566 C  CA  . ALA B 1 297 ? -40.518 -8.299  18.796  1.00 37.89 ? 302 ALA B CA  1 
ATOM   4567 C  C   . ALA B 1 297 ? -41.646 -7.272  18.803  1.00 38.84 ? 302 ALA B C   1 
ATOM   4568 O  O   . ALA B 1 297 ? -42.698 -7.494  19.410  1.00 39.24 ? 302 ALA B O   1 
ATOM   4569 C  CB  . ALA B 1 297 ? -40.695 -9.267  17.657  1.00 37.60 ? 302 ALA B CB  1 
ATOM   4570 N  N   . THR B 1 298 ? -41.430 -6.149  18.135  1.00 39.52 ? 303 THR B N   1 
ATOM   4571 C  CA  . THR B 1 298 ? -42.454 -5.125  18.043  1.00 40.63 ? 303 THR B CA  1 
ATOM   4572 C  C   . THR B 1 298 ? -43.373 -5.335  16.844  1.00 41.19 ? 303 THR B C   1 
ATOM   4573 O  O   . THR B 1 298 ? -44.343 -4.600  16.679  1.00 41.54 ? 303 THR B O   1 
ATOM   4574 C  CB  . THR B 1 298 ? -41.842 -3.714  17.960  1.00 40.49 ? 303 THR B CB  1 
ATOM   4575 O  OG1 . THR B 1 298 ? -41.247 -3.541  16.668  1.00 40.90 ? 303 THR B OG1 1 
ATOM   4576 C  CG2 . THR B 1 298 ? -40.800 -3.510  19.057  1.00 40.61 ? 303 THR B CG2 1 
ATOM   4577 N  N   . SER B 1 299 ? -43.053 -6.321  16.004  1.00 41.52 ? 304 SER B N   1 
ATOM   4578 C  CA  . SER B 1 299 ? -43.869 -6.666  14.837  1.00 42.12 ? 304 SER B CA  1 
ATOM   4579 C  C   . SER B 1 299 ? -43.648 -8.128  14.481  1.00 42.54 ? 304 SER B C   1 
ATOM   4580 O  O   . SER B 1 299 ? -42.732 -8.778  15.014  1.00 42.68 ? 304 SER B O   1 
ATOM   4581 C  CB  . SER B 1 299 ? -43.532 -5.778  13.631  1.00 42.19 ? 304 SER B CB  1 
ATOM   4582 O  OG  . SER B 1 299 ? -42.287 -6.148  13.061  1.00 42.62 ? 304 SER B OG  1 
ATOM   4583 N  N   . GLU B 1 300 ? -44.475 -8.654  13.583  1.00 42.44 ? 305 GLU B N   1 
ATOM   4584 C  CA  . GLU B 1 300 ? -44.323 -10.035 13.152  1.00 42.97 ? 305 GLU B CA  1 
ATOM   4585 C  C   . GLU B 1 300 ? -43.070 -10.273 12.284  1.00 42.50 ? 305 GLU B C   1 
ATOM   4586 O  O   . GLU B 1 300 ? -42.491 -11.361 12.329  1.00 42.15 ? 305 GLU B O   1 
ATOM   4587 C  CB  . GLU B 1 300 ? -45.585 -10.554 12.446  1.00 43.48 ? 305 GLU B CB  1 
ATOM   4588 C  CG  . GLU B 1 300 ? -45.840 -12.035 12.726  1.00 45.88 ? 305 GLU B CG  1 
ATOM   4589 C  CD  . GLU B 1 300 ? -47.107 -12.583 12.064  1.00 48.95 ? 305 GLU B CD  1 
ATOM   4590 O  OE1 . GLU B 1 300 ? -48.015 -11.792 11.719  1.00 49.11 ? 305 GLU B OE1 1 
ATOM   4591 O  OE2 . GLU B 1 300 ? -47.186 -13.822 11.900  1.00 49.82 ? 305 GLU B OE2 1 
ATOM   4592 N  N   . GLU B 1 301 ? -42.649 -9.267  11.515  1.00 41.89 ? 306 GLU B N   1 
ATOM   4593 C  CA  . GLU B 1 301 ? -41.432 -9.405  10.720  1.00 41.58 ? 306 GLU B CA  1 
ATOM   4594 C  C   . GLU B 1 301 ? -40.169 -9.483  11.600  1.00 40.10 ? 306 GLU B C   1 
ATOM   4595 O  O   . GLU B 1 301 ? -39.344 -10.372 11.406  1.00 40.50 ? 306 GLU B O   1 
ATOM   4596 C  CB  . GLU B 1 301 ? -41.335 -8.343  9.601   1.00 42.44 ? 306 GLU B CB  1 
ATOM   4597 C  CG  . GLU B 1 301 ? -41.052 -6.903  10.053  1.00 45.76 ? 306 GLU B CG  1 
ATOM   4598 C  CD  . GLU B 1 301 ? -40.440 -6.038  8.950   1.00 49.27 ? 306 GLU B CD  1 
ATOM   4599 O  OE1 . GLU B 1 301 ? -40.961 -6.063  7.810   1.00 50.13 ? 306 GLU B OE1 1 
ATOM   4600 O  OE2 . GLU B 1 301 ? -39.441 -5.327  9.230   1.00 50.59 ? 306 GLU B OE2 1 
ATOM   4601 N  N   . GLU B 1 302 ? -40.039 -8.580  12.575  1.00 38.32 ? 307 GLU B N   1 
ATOM   4602 C  CA  . GLU B 1 302 ? -38.954 -8.644  13.561  1.00 36.50 ? 307 GLU B CA  1 
ATOM   4603 C  C   . GLU B 1 302 ? -38.866 -10.028 14.207  1.00 35.30 ? 307 GLU B C   1 
ATOM   4604 O  O   . GLU B 1 302 ? -37.770 -10.559 14.397  1.00 33.83 ? 307 GLU B O   1 
ATOM   4605 C  CB  . GLU B 1 302 ? -39.129 -7.594  14.661  1.00 36.76 ? 307 GLU B CB  1 
ATOM   4606 C  CG  . GLU B 1 302 ? -38.710 -6.163  14.306  1.00 37.07 ? 307 GLU B CG  1 
ATOM   4607 C  CD  . GLU B 1 302 ? -38.647 -5.260  15.535  1.00 38.24 ? 307 GLU B CD  1 
ATOM   4608 O  OE1 . GLU B 1 302 ? -38.798 -5.749  16.675  1.00 39.93 ? 307 GLU B OE1 1 
ATOM   4609 O  OE2 . GLU B 1 302 ? -38.448 -4.046  15.369  1.00 39.65 ? 307 GLU B OE2 1 
ATOM   4610 N  N   . ALA B 1 303 ? -40.026 -10.605 14.547  1.00 33.64 ? 308 ALA B N   1 
ATOM   4611 C  CA  . ALA B 1 303 ? -40.068 -11.951 15.148  1.00 32.82 ? 308 ALA B CA  1 
ATOM   4612 C  C   . ALA B 1 303 ? -39.551 -12.990 14.164  1.00 31.66 ? 308 ALA B C   1 
ATOM   4613 O  O   . ALA B 1 303 ? -38.678 -13.789 14.482  1.00 30.88 ? 308 ALA B O   1 
ATOM   4614 C  CB  . ALA B 1 303 ? -41.507 -12.312 15.620  1.00 32.75 ? 308 ALA B CB  1 
ATOM   4615 N  N   . LYS B 1 304 ? -40.090 -12.941 12.953  1.00 31.01 ? 309 LYS B N   1 
ATOM   4616 C  CA  . LYS B 1 304 ? -39.711 -13.858 11.896  1.00 30.71 ? 309 LYS B CA  1 
ATOM   4617 C  C   . LYS B 1 304 ? -38.232 -13.699 11.459  1.00 29.79 ? 309 LYS B C   1 
ATOM   4618 O  O   . LYS B 1 304 ? -37.541 -14.695 11.273  1.00 28.88 ? 309 LYS B O   1 
ATOM   4619 C  CB  . LYS B 1 304 ? -40.654 -13.705 10.694  1.00 31.44 ? 309 LYS B CB  1 
ATOM   4620 C  CG  . LYS B 1 304 ? -42.126 -14.105 10.990  1.00 34.12 ? 309 LYS B CG  1 
ATOM   4621 C  CD  . LYS B 1 304 ? -42.927 -14.195 9.712   1.00 39.35 ? 309 LYS B CD  1 
ATOM   4622 C  CE  . LYS B 1 304 ? -44.210 -15.007 9.894   1.00 42.88 ? 309 LYS B CE  1 
ATOM   4623 N  NZ  . LYS B 1 304 ? -44.735 -15.431 8.564   1.00 43.80 ? 309 LYS B NZ  1 
ATOM   4624 N  N   . THR B 1 305 ? -37.750 -12.465 11.307  1.00 28.81 ? 310 THR B N   1 
ATOM   4625 C  CA  . THR B 1 305 ? -36.344 -12.279 10.879  1.00 27.96 ? 310 THR B CA  1 
ATOM   4626 C  C   . THR B 1 305 ? -35.373 -12.895 11.889  1.00 26.07 ? 310 THR B C   1 
ATOM   4627 O  O   . THR B 1 305 ? -34.360 -13.515 11.502  1.00 25.80 ? 310 THR B O   1 
ATOM   4628 C  CB  . THR B 1 305 ? -35.972 -10.816 10.642  1.00 27.73 ? 310 THR B CB  1 
ATOM   4629 O  OG1 . THR B 1 305 ? -37.041 -10.160 9.956   1.00 32.57 ? 310 THR B OG1 1 
ATOM   4630 C  CG2 . THR B 1 305 ? -34.778 -10.738 9.746   1.00 27.19 ? 310 THR B CG2 1 
ATOM   4631 N  N   . THR B 1 306 ? -35.699 -12.741 13.171  1.00 24.51 ? 311 THR B N   1 
ATOM   4632 C  CA  . THR B 1 306 ? -34.909 -13.310 14.259  1.00 23.62 ? 311 THR B CA  1 
ATOM   4633 C  C   . THR B 1 306 ? -34.864 -14.838 14.178  1.00 23.53 ? 311 THR B C   1 
ATOM   4634 O  O   . THR B 1 306 ? -33.813 -15.452 14.382  1.00 22.21 ? 311 THR B O   1 
ATOM   4635 C  CB  . THR B 1 306 ? -35.445 -12.879 15.663  1.00 23.52 ? 311 THR B CB  1 
ATOM   4636 O  OG1 . THR B 1 306 ? -35.420 -11.451 15.790  1.00 22.67 ? 311 THR B OG1 1 
ATOM   4637 C  CG2 . THR B 1 306 ? -34.605 -13.480 16.777  1.00 21.33 ? 311 THR B CG2 1 
ATOM   4638 N  N   . ALA B 1 307 ? -36.019 -15.449 13.891  1.00 23.02 ? 312 ALA B N   1 
ATOM   4639 C  CA  . ALA B 1 307 ? -36.132 -16.895 13.760  1.00 21.86 ? 312 ALA B CA  1 
ATOM   4640 C  C   . ALA B 1 307 ? -35.453 -17.354 12.448  1.00 21.67 ? 312 ALA B C   1 
ATOM   4641 O  O   . ALA B 1 307 ? -34.776 -18.366 12.416  1.00 20.81 ? 312 ALA B O   1 
ATOM   4642 C  CB  . ALA B 1 307 ? -37.625 -17.298 13.777  1.00 22.59 ? 312 ALA B CB  1 
ATOM   4643 N  N   . ASN B 1 308 ? -35.613 -16.592 11.368  1.00 22.54 ? 313 ASN B N   1 
ATOM   4644 C  CA  . ASN B 1 308 ? -34.883 -16.923 10.138  1.00 22.29 ? 313 ASN B CA  1 
ATOM   4645 C  C   . ASN B 1 308 ? -33.356 -16.889 10.315  1.00 21.92 ? 313 ASN B C   1 
ATOM   4646 O  O   . ASN B 1 308 ? -32.629 -17.719 9.772   1.00 22.45 ? 313 ASN B O   1 
ATOM   4647 C  CB  . ASN B 1 308 ? -35.269 -15.975 9.015   1.00 23.59 ? 313 ASN B CB  1 
ATOM   4648 C  CG  . ASN B 1 308 ? -36.697 -16.197 8.540   1.00 26.36 ? 313 ASN B CG  1 
ATOM   4649 O  OD1 . ASN B 1 308 ? -37.247 -17.272 8.719   1.00 29.89 ? 313 ASN B OD1 1 
ATOM   4650 N  ND2 . ASN B 1 308 ? -37.307 -15.166 7.977   1.00 29.21 ? 313 ASN B ND2 1 
ATOM   4651 N  N   . LEU B 1 309 ? -32.886 -15.904 11.060  1.00 20.43 ? 314 LEU B N   1 
ATOM   4652 C  CA  . LEU B 1 309 ? -31.455 -15.800 11.393  1.00 19.29 ? 314 LEU B CA  1 
ATOM   4653 C  C   . LEU B 1 309 ? -30.986 -17.017 12.193  1.00 18.75 ? 314 LEU B C   1 
ATOM   4654 O  O   . LEU B 1 309 ? -29.893 -17.577 11.947  1.00 17.42 ? 314 LEU B O   1 
ATOM   4655 C  CB  . LEU B 1 309 ? -31.202 -14.523 12.175  1.00 17.46 ? 314 LEU B CB  1 
ATOM   4656 C  CG  . LEU B 1 309 ? -29.745 -14.300 12.587  1.00 17.74 ? 314 LEU B CG  1 
ATOM   4657 C  CD1 . LEU B 1 309 ? -28.886 -14.272 11.343  1.00 17.31 ? 314 LEU B CD1 1 
ATOM   4658 C  CD2 . LEU B 1 309 ? -29.594 -13.002 13.421  1.00 16.28 ? 314 LEU B CD2 1 
ATOM   4659 N  N   . ALA B 1 310 ? -31.817 -17.443 13.145  1.00 18.26 ? 315 ALA B N   1 
ATOM   4660 C  CA  . ALA B 1 310 ? -31.512 -18.632 13.936  1.00 18.25 ? 315 ALA B CA  1 
ATOM   4661 C  C   . ALA B 1 310 ? -31.353 -19.877 13.056  1.00 18.51 ? 315 ALA B C   1 
ATOM   4662 O  O   . ALA B 1 310 ? -30.463 -20.699 13.288  1.00 18.34 ? 315 ALA B O   1 
ATOM   4663 C  CB  . ALA B 1 310 ? -32.635 -18.856 15.020  1.00 18.30 ? 315 ALA B CB  1 
ATOM   4664 N  N   . VAL B 1 311 ? -32.241 -20.027 12.075  1.00 19.37 ? 316 VAL B N   1 
ATOM   4665 C  CA  . VAL B 1 311 ? -32.168 -21.148 11.110  1.00 20.04 ? 316 VAL B CA  1 
ATOM   4666 C  C   . VAL B 1 311 ? -30.849 -21.120 10.316  1.00 19.47 ? 316 VAL B C   1 
ATOM   4667 O  O   . VAL B 1 311 ? -30.148 -22.120 10.228  1.00 19.96 ? 316 VAL B O   1 
ATOM   4668 C  CB  . VAL B 1 311 ? -33.417 -21.182 10.146  1.00 20.60 ? 316 VAL B CB  1 
ATOM   4669 C  CG1 . VAL B 1 311 ? -33.213 -22.209 9.069   1.00 21.09 ? 316 VAL B CG1 1 
ATOM   4670 C  CG2 . VAL B 1 311 ? -34.680 -21.567 10.948  1.00 21.40 ? 316 VAL B CG2 1 
ATOM   4671 N  N   . ASP B 1 312 ? -30.508 -19.938 9.805   1.00 19.38 ? 317 ASP B N   1 
ATOM   4672 C  CA  . ASP B 1 312 ? -29.259 -19.713 9.080   1.00 19.21 ? 317 ASP B CA  1 
ATOM   4673 C  C   . ASP B 1 312 ? -28.019 -20.113 9.867   1.00 18.62 ? 317 ASP B C   1 
ATOM   4674 O  O   . ASP B 1 312 ? -27.110 -20.729 9.328   1.00 17.56 ? 317 ASP B O   1 
ATOM   4675 C  CB  . ASP B 1 312 ? -29.182 -18.234 8.665   1.00 19.73 ? 317 ASP B CB  1 
ATOM   4676 C  CG  . ASP B 1 312 ? -30.036 -17.917 7.488   1.00 20.89 ? 317 ASP B CG  1 
ATOM   4677 O  OD1 . ASP B 1 312 ? -30.626 -18.853 6.885   1.00 21.83 ? 317 ASP B OD1 1 
ATOM   4678 O  OD2 . ASP B 1 312 ? -30.125 -16.721 7.140   1.00 21.96 ? 317 ASP B OD2 1 
ATOM   4679 N  N   . VAL B 1 313 ? -27.974 -19.782 11.156  1.00 18.37 ? 318 VAL B N   1 
ATOM   4680 C  CA  . VAL B 1 313 ? -26.849 -20.212 12.011  1.00 16.99 ? 318 VAL B CA  1 
ATOM   4681 C  C   . VAL B 1 313 ? -26.739 -21.734 12.082  1.00 17.19 ? 318 VAL B C   1 
ATOM   4682 O  O   . VAL B 1 313 ? -25.661 -22.289 11.918  1.00 16.33 ? 318 VAL B O   1 
ATOM   4683 C  CB  . VAL B 1 313 ? -26.917 -19.614 13.436  1.00 17.01 ? 318 VAL B CB  1 
ATOM   4684 C  CG1 . VAL B 1 313 ? -25.824 -20.193 14.366  1.00 15.80 ? 318 VAL B CG1 1 
ATOM   4685 C  CG2 . VAL B 1 313 ? -26.776 -18.091 13.357  1.00 15.67 ? 318 VAL B CG2 1 
ATOM   4686 N  N   . ILE B 1 314 ? -27.870 -22.390 12.325  1.00 17.83 ? 319 ILE B N   1 
ATOM   4687 C  CA  . ILE B 1 314 ? -27.899 -23.830 12.500  1.00 18.50 ? 319 ILE B CA  1 
ATOM   4688 C  C   . ILE B 1 314 ? -27.554 -24.507 11.172  1.00 18.44 ? 319 ILE B C   1 
ATOM   4689 O  O   . ILE B 1 314 ? -26.712 -25.388 11.150  1.00 18.77 ? 319 ILE B O   1 
ATOM   4690 C  CB  . ILE B 1 314 ? -29.271 -24.320 13.045  1.00 18.64 ? 319 ILE B CB  1 
ATOM   4691 C  CG1 . ILE B 1 314 ? -29.566 -23.622 14.380  1.00 18.97 ? 319 ILE B CG1 1 
ATOM   4692 C  CG2 . ILE B 1 314 ? -29.199 -25.855 13.258  1.00 18.80 ? 319 ILE B CG2 1 
ATOM   4693 C  CD1 . ILE B 1 314 ? -31.015 -23.746 14.873  1.00 20.32 ? 319 ILE B CD1 1 
ATOM   4694 N  N   . ALA B 1 315 ? -28.161 -24.058 10.078  1.00 19.69 ? 320 ALA B N   1 
ATOM   4695 C  CA  . ALA B 1 315 ? -27.895 -24.657 8.762   1.00 19.88 ? 320 ALA B CA  1 
ATOM   4696 C  C   . ALA B 1 315 ? -26.420 -24.500 8.366   1.00 21.09 ? 320 ALA B C   1 
ATOM   4697 O  O   . ALA B 1 315 ? -25.801 -25.458 7.925   1.00 21.11 ? 320 ALA B O   1 
ATOM   4698 C  CB  . ALA B 1 315 ? -28.813 -24.081 7.714   1.00 20.66 ? 320 ALA B CB  1 
ATOM   4699 N  N   . SER B 1 316 ? -25.831 -23.322 8.585   1.00 20.93 ? 321 SER B N   1 
ATOM   4700 C  CA  . SER B 1 316 ? -24.385 -23.136 8.283   1.00 20.57 ? 321 SER B CA  1 
ATOM   4701 C  C   . SER B 1 316 ? -23.485 -23.925 9.186   1.00 19.80 ? 321 SER B C   1 
ATOM   4702 O  O   . SER B 1 316 ? -22.378 -24.330 8.790   1.00 19.89 ? 321 SER B O   1 
ATOM   4703 C  CB  . SER B 1 316 ? -23.996 -21.657 8.326   1.00 20.75 ? 321 SER B CB  1 
ATOM   4704 O  OG  . SER B 1 316 ? -25.005 -20.906 7.673   1.00 22.41 ? 321 SER B OG  1 
ATOM   4705 N  N   . SER B 1 317 ? -23.929 -24.179 10.418  1.00 20.06 ? 322 SER B N   1 
ATOM   4706 C  CA  . SER B 1 317 ? -23.107 -25.001 11.306  1.00 20.25 ? 322 SER B CA  1 
ATOM   4707 C  C   . SER B 1 317 ? -23.041 -26.448 10.804  1.00 20.52 ? 322 SER B C   1 
ATOM   4708 O  O   . SER B 1 317 ? -22.141 -27.189 11.194  1.00 20.71 ? 322 SER B O   1 
ATOM   4709 C  CB  . SER B 1 317 ? -23.653 -24.959 12.735  1.00 20.57 ? 322 SER B CB  1 
ATOM   4710 O  OG  . SER B 1 317 ? -23.665 -23.600 13.182  1.00 21.99 ? 322 SER B OG  1 
ATOM   4711 N  N   . PHE B 1 318 ? -24.011 -26.819 9.961   1.00 20.33 ? 323 PHE B N   1 
ATOM   4712 C  CA  . PHE B 1 318 ? -24.104 -28.170 9.375   1.00 22.24 ? 323 PHE B CA  1 
ATOM   4713 C  C   . PHE B 1 318 ? -23.891 -28.258 7.874   1.00 22.09 ? 323 PHE B C   1 
ATOM   4714 O  O   . PHE B 1 318 ? -24.211 -29.264 7.268   1.00 22.60 ? 323 PHE B O   1 
ATOM   4715 C  CB  . PHE B 1 318 ? -25.411 -28.882 9.805   1.00 22.24 ? 323 PHE B CB  1 
ATOM   4716 C  CG  . PHE B 1 318 ? -25.384 -29.248 11.248  1.00 22.60 ? 323 PHE B CG  1 
ATOM   4717 C  CD1 . PHE B 1 318 ? -24.656 -30.347 11.670  1.00 21.82 ? 323 PHE B CD1 1 
ATOM   4718 C  CD2 . PHE B 1 318 ? -25.985 -28.428 12.195  1.00 23.44 ? 323 PHE B CD2 1 
ATOM   4719 C  CE1 . PHE B 1 318 ? -24.549 -30.656 13.026  1.00 24.13 ? 323 PHE B CE1 1 
ATOM   4720 C  CE2 . PHE B 1 318 ? -25.889 -28.734 13.551  1.00 22.01 ? 323 PHE B CE2 1 
ATOM   4721 C  CZ  . PHE B 1 318 ? -25.162 -29.843 13.967  1.00 22.64 ? 323 PHE B CZ  1 
ATOM   4722 N  N   . GLY B 1 319 ? -23.330 -27.216 7.272   1.00 21.62 ? 324 GLY B N   1 
ATOM   4723 C  CA  . GLY B 1 319 ? -22.896 -27.333 5.882   1.00 21.42 ? 324 GLY B CA  1 
ATOM   4724 C  C   . GLY B 1 319 ? -23.469 -26.344 4.896   1.00 22.25 ? 324 GLY B C   1 
ATOM   4725 O  O   . GLY B 1 319 ? -22.995 -26.271 3.764   1.00 22.02 ? 324 GLY B O   1 
ATOM   4726 N  N   . GLN B 1 320 ? -24.499 -25.588 5.268   1.00 22.33 ? 325 GLN B N   1 
ATOM   4727 C  CA  . GLN B 1 320 ? -24.924 -24.561 4.340   1.00 23.75 ? 325 GLN B CA  1 
ATOM   4728 C  C   . GLN B 1 320 ? -23.743 -23.585 4.106   1.00 23.52 ? 325 GLN B C   1 
ATOM   4729 O  O   . GLN B 1 320 ? -23.061 -23.183 5.060   1.00 23.28 ? 325 GLN B O   1 
ATOM   4730 C  CB  . GLN B 1 320 ? -26.139 -23.835 4.845   1.00 24.16 ? 325 GLN B CB  1 
ATOM   4731 C  CG  . GLN B 1 320 ? -26.692 -22.794 3.889   1.00 28.71 ? 325 GLN B CG  1 
ATOM   4732 C  CD  . GLN B 1 320 ? -27.912 -22.178 4.493   1.00 35.36 ? 325 GLN B CD  1 
ATOM   4733 O  OE1 . GLN B 1 320 ? -27.844 -21.118 5.148   1.00 40.94 ? 325 GLN B OE1 1 
ATOM   4734 N  NE2 . GLN B 1 320 ? -29.028 -22.872 4.365   1.00 34.27 ? 325 GLN B NE2 1 
ATOM   4735 N  N   . THR B 1 321 ? -23.505 -23.254 2.827   1.00 24.05 ? 326 THR B N   1 
ATOM   4736 C  CA  . THR B 1 321 ? -22.410 -22.383 2.407   1.00 24.33 ? 326 THR B CA  1 
ATOM   4737 C  C   . THR B 1 321 ? -22.949 -21.198 1.620   1.00 24.33 ? 326 THR B C   1 
ATOM   4738 O  O   . THR B 1 321 ? -24.068 -21.212 1.136   1.00 24.38 ? 326 THR B O   1 
ATOM   4739 C  CB  . THR B 1 321 ? -21.378 -23.092 1.432   1.00 24.22 ? 326 THR B CB  1 
ATOM   4740 O  OG1 . THR B 1 321 ? -21.921 -23.134 0.105   1.00 24.80 ? 326 THR B OG1 1 
ATOM   4741 C  CG2 . THR B 1 321 ? -21.037 -24.516 1.851   1.00 24.35 ? 326 THR B CG2 1 
ATOM   4742 N  N   . ARG B 1 322 ? -22.092 -20.206 1.436   1.00 23.93 ? 327 ARG B N   1 
ATOM   4743 C  CA  . ARG B 1 322 ? -22.403 -19.010 0.674   1.00 24.76 ? 327 ARG B CA  1 
ATOM   4744 C  C   . ARG B 1 322 ? -21.860 -19.246 -0.756  1.00 25.23 ? 327 ARG B C   1 
ATOM   4745 O  O   . ARG B 1 322 ? -21.606 -18.314 -1.501  1.00 24.94 ? 327 ARG B O   1 
ATOM   4746 C  CB  . ARG B 1 322 ? -21.655 -17.837 1.323   1.00 23.62 ? 327 ARG B CB  1 
ATOM   4747 C  CG  . ARG B 1 322 ? -22.494 -16.674 1.839   1.00 27.92 ? 327 ARG B CG  1 
ATOM   4748 C  CD  . ARG B 1 322 ? -22.484 -16.462 3.368   1.00 22.02 ? 327 ARG B CD  1 
ATOM   4749 N  NE  . ARG B 1 322 ? -21.193 -16.646 4.025   1.00 15.67 ? 327 ARG B NE  1 
ATOM   4750 C  CZ  . ARG B 1 322 ? -20.423 -15.677 4.516   1.00 15.61 ? 327 ARG B CZ  1 
ATOM   4751 N  NH1 . ARG B 1 322 ? -20.763 -14.396 4.380   1.00 14.08 ? 327 ARG B NH1 1 
ATOM   4752 N  NH2 . ARG B 1 322 ? -19.281 -15.990 5.135   1.00 13.24 ? 327 ARG B NH2 1 
ATOM   4753 N  N   . GLU B 1 323 ? -21.644 -20.504 -1.133  1.00 26.95 ? 328 GLU B N   1 
ATOM   4754 C  CA  . GLU B 1 323 ? -20.879 -20.790 -2.364  1.00 28.30 ? 328 GLU B CA  1 
ATOM   4755 C  C   . GLU B 1 323 ? -21.436 -21.980 -3.130  1.00 28.83 ? 328 GLU B C   1 
ATOM   4756 O  O   . GLU B 1 323 ? -20.863 -22.381 -4.132  1.00 28.48 ? 328 GLU B O   1 
ATOM   4757 C  CB  . GLU B 1 323 ? -19.379 -20.983 -2.049  1.00 28.82 ? 328 GLU B CB  1 
ATOM   4758 C  CG  . GLU B 1 323 ? -18.655 -19.705 -1.549  1.00 30.96 ? 328 GLU B CG  1 
ATOM   4759 C  CD  . GLU B 1 323 ? -17.140 -19.862 -1.427  1.00 32.55 ? 328 GLU B CD  1 
ATOM   4760 O  OE1 . GLU B 1 323 ? -16.648 -20.925 -1.887  1.00 32.24 ? 328 GLU B OE1 1 
ATOM   4761 O  OE2 . GLU B 1 323 ? -16.451 -18.911 -0.907  1.00 28.03 ? 328 GLU B OE2 1 
ATOM   4762 N  N   . GLY B 1 324 ? -22.569 -22.519 -2.669  1.00 29.47 ? 329 GLY B N   1 
ATOM   4763 C  CA  . GLY B 1 324 ? -23.212 -23.663 -3.313  1.00 30.34 ? 329 GLY B CA  1 
ATOM   4764 C  C   . GLY B 1 324 ? -22.432 -24.965 -3.241  1.00 31.13 ? 329 GLY B C   1 
ATOM   4765 O  O   . GLY B 1 324 ? -22.636 -25.863 -4.076  1.00 31.25 ? 329 GLY B O   1 
ATOM   4766 N  N   . GLY B 1 325 ? -21.558 -25.074 -2.243  1.00 31.45 ? 330 GLY B N   1 
ATOM   4767 C  CA  . GLY B 1 325 ? -20.637 -26.208 -2.129  1.00 33.52 ? 330 GLY B CA  1 
ATOM   4768 C  C   . GLY B 1 325 ? -21.041 -27.309 -1.155  1.00 34.52 ? 330 GLY B C   1 
ATOM   4769 O  O   . GLY B 1 325 ? -20.207 -28.139 -0.777  1.00 35.22 ? 330 GLY B O   1 
ATOM   4770 N  N   . HIS B 1 326 ? -22.316 -27.347 -0.777  1.00 35.52 ? 331 HIS B N   1 
ATOM   4771 C  CA  . HIS B 1 326 ? -22.793 -28.343 0.192   1.00 37.13 ? 331 HIS B CA  1 
ATOM   4772 C  C   . HIS B 1 326 ? -22.897 -29.783 -0.375  1.00 37.82 ? 331 HIS B C   1 
ATOM   4773 O  O   . HIS B 1 326 ? -22.555 -30.739 0.324   1.00 38.11 ? 331 HIS B O   1 
ATOM   4774 C  CB  . HIS B 1 326 ? -24.099 -27.887 0.864   1.00 37.07 ? 331 HIS B CB  1 
ATOM   4775 C  CG  . HIS B 1 326 ? -25.239 -27.675 -0.087  1.00 39.14 ? 331 HIS B CG  1 
ATOM   4776 N  ND1 . HIS B 1 326 ? -25.340 -26.562 -0.901  1.00 39.67 ? 331 HIS B ND1 1 
ATOM   4777 C  CD2 . HIS B 1 326 ? -26.339 -28.430 -0.342  1.00 39.25 ? 331 HIS B CD2 1 
ATOM   4778 C  CE1 . HIS B 1 326 ? -26.442 -26.649 -1.628  1.00 39.76 ? 331 HIS B CE1 1 
ATOM   4779 N  NE2 . HIS B 1 326 ? -27.068 -27.772 -1.307  1.00 40.11 ? 331 HIS B NE2 1 
ATOM   4780 N  N   . ILE B 1 327 ? -23.351 -29.926 -1.624  1.00 38.33 ? 332 ILE B N   1 
ATOM   4781 C  CA  . ILE B 1 327 ? -23.488 -31.251 -2.270  1.00 39.20 ? 332 ILE B CA  1 
ATOM   4782 C  C   . ILE B 1 327 ? -22.319 -31.536 -3.196  1.00 38.62 ? 332 ILE B C   1 
ATOM   4783 O  O   . ILE B 1 327 ? -21.691 -30.615 -3.730  1.00 39.03 ? 332 ILE B O   1 
ATOM   4784 C  CB  . ILE B 1 327 ? -24.764 -31.400 -3.160  1.00 39.60 ? 332 ILE B CB  1 
ATOM   4785 C  CG1 . ILE B 1 327 ? -25.748 -30.249 -2.954  1.00 40.31 ? 332 ILE B CG1 1 
ATOM   4786 C  CG2 . ILE B 1 327 ? -25.401 -32.800 -2.965  1.00 41.10 ? 332 ILE B CG2 1 
ATOM   4787 C  CD1 . ILE B 1 327 ? -27.141 -30.513 -3.480  1.00 42.68 ? 332 ILE B CD1 1 
ATOM   4788 N  N   . VAL B 1 328 ? -22.040 -32.820 -3.398  1.00 37.87 ? 333 VAL B N   1 
ATOM   4789 C  CA  . VAL B 1 328 ? -21.097 -33.232 -4.430  1.00 36.88 ? 333 VAL B CA  1 
ATOM   4790 C  C   . VAL B 1 328 ? -21.808 -33.101 -5.783  1.00 36.29 ? 333 VAL B C   1 
ATOM   4791 O  O   . VAL B 1 328 ? -22.975 -33.504 -5.930  1.00 35.40 ? 333 VAL B O   1 
ATOM   4792 C  CB  . VAL B 1 328 ? -20.591 -34.682 -4.211  1.00 37.21 ? 333 VAL B CB  1 
ATOM   4793 C  CG1 . VAL B 1 328 ? -19.409 -34.997 -5.160  1.00 38.17 ? 333 VAL B CG1 1 
ATOM   4794 C  CG2 . VAL B 1 328 ? -20.175 -34.890 -2.742  1.00 37.31 ? 333 VAL B CG2 1 
ATOM   4795 N  N   . TYR B 1 329 ? -21.114 -32.502 -6.748  1.00 34.71 ? 334 TYR B N   1 
ATOM   4796 C  CA  . TYR B 1 329 ? -21.627 -32.405 -8.126  1.00 34.10 ? 334 TYR B CA  1 
ATOM   4797 C  C   . TYR B 1 329 ? -20.474 -32.811 -9.031  1.00 33.88 ? 334 TYR B C   1 
ATOM   4798 O  O   . TYR B 1 329 ? -19.364 -32.265 -8.924  1.00 33.81 ? 334 TYR B O   1 
ATOM   4799 C  CB  . TYR B 1 329 ? -22.125 -30.988 -8.437  1.00 33.73 ? 334 TYR B CB  1 
ATOM   4800 C  CG  . TYR B 1 329 ? -22.933 -30.850 -9.722  1.00 31.35 ? 334 TYR B CG  1 
ATOM   4801 C  CD1 . TYR B 1 329 ? -24.316 -30.791 -9.690  1.00 29.72 ? 334 TYR B CD1 1 
ATOM   4802 C  CD2 . TYR B 1 329 ? -22.297 -30.764 -10.975 1.00 31.62 ? 334 TYR B CD2 1 
ATOM   4803 C  CE1 . TYR B 1 329 ? -25.067 -30.647 -10.882 1.00 27.60 ? 334 TYR B CE1 1 
ATOM   4804 C  CE2 . TYR B 1 329 ? -23.038 -30.624 -12.178 1.00 28.68 ? 334 TYR B CE2 1 
ATOM   4805 C  CZ  . TYR B 1 329 ? -24.416 -30.578 -12.112 1.00 27.66 ? 334 TYR B CZ  1 
ATOM   4806 O  OH  . TYR B 1 329 ? -25.146 -30.431 -13.277 1.00 25.44 ? 334 TYR B OH  1 
ATOM   4807 N  N   . ASP B 1 330 ? -20.743 -33.800 -9.876  1.00 33.61 ? 335 ASP B N   1 
ATOM   4808 C  CA  . ASP B 1 330 ? -19.718 -34.592 -10.566 1.00 34.31 ? 335 ASP B CA  1 
ATOM   4809 C  C   . ASP B 1 330 ? -19.571 -34.295 -12.049 1.00 32.48 ? 335 ASP B C   1 
ATOM   4810 O  O   . ASP B 1 330 ? -18.461 -34.354 -12.613 1.00 32.01 ? 335 ASP B O   1 
ATOM   4811 C  CB  . ASP B 1 330 ? -20.079 -36.082 -10.442 1.00 34.78 ? 335 ASP B CB  1 
ATOM   4812 C  CG  . ASP B 1 330 ? -19.288 -36.784 -9.363  1.00 39.98 ? 335 ASP B CG  1 
ATOM   4813 O  OD1 . ASP B 1 330 ? -18.095 -36.439 -9.184  1.00 44.95 ? 335 ASP B OD1 1 
ATOM   4814 O  OD2 . ASP B 1 330 ? -19.847 -37.688 -8.696  1.00 44.82 ? 335 ASP B OD2 1 
ATOM   4815 N  N   . GLN B 1 331 ? -20.701 -33.998 -12.678 1.00 30.17 ? 336 GLN B N   1 
ATOM   4816 C  CA  . GLN B 1 331 ? -20.805 -34.099 -14.128 1.00 29.54 ? 336 GLN B CA  1 
ATOM   4817 C  C   . GLN B 1 331 ? -21.920 -33.194 -14.631 1.00 27.50 ? 336 GLN B C   1 
ATOM   4818 O  O   . GLN B 1 331 ? -23.047 -33.298 -14.172 1.00 25.83 ? 336 GLN B O   1 
ATOM   4819 C  CB  . GLN B 1 331 ? -21.187 -35.534 -14.484 1.00 29.91 ? 336 GLN B CB  1 
ATOM   4820 C  CG  . GLN B 1 331 ? -20.566 -36.070 -15.744 1.00 34.45 ? 336 GLN B CG  1 
ATOM   4821 C  CD  . GLN B 1 331 ? -20.959 -37.518 -15.982 1.00 39.82 ? 336 GLN B CD  1 
ATOM   4822 O  OE1 . GLN B 1 331 ? -22.084 -37.810 -16.413 1.00 43.28 ? 336 GLN B OE1 1 
ATOM   4823 N  NE2 . GLN B 1 331 ? -20.036 -38.433 -15.703 1.00 40.78 ? 336 GLN B NE2 1 
ATOM   4824 N  N   . LEU B 1 332 ? -21.607 -32.325 -15.588 1.00 26.27 ? 337 LEU B N   1 
ATOM   4825 C  CA  . LEU B 1 332 ? -22.637 -31.489 -16.198 1.00 25.76 ? 337 LEU B CA  1 
ATOM   4826 C  C   . LEU B 1 332 ? -23.471 -32.292 -17.178 1.00 24.77 ? 337 LEU B C   1 
ATOM   4827 O  O   . LEU B 1 332 ? -22.942 -33.156 -17.859 1.00 24.99 ? 337 LEU B O   1 
ATOM   4828 C  CB  . LEU B 1 332 ? -22.013 -30.308 -16.951 1.00 25.67 ? 337 LEU B CB  1 
ATOM   4829 C  CG  . LEU B 1 332 ? -21.431 -29.197 -16.084 1.00 24.79 ? 337 LEU B CG  1 
ATOM   4830 C  CD1 . LEU B 1 332 ? -20.500 -28.302 -16.917 1.00 22.71 ? 337 LEU B CD1 1 
ATOM   4831 C  CD2 . LEU B 1 332 ? -22.559 -28.382 -15.460 1.00 22.98 ? 337 LEU B CD2 1 
ATOM   4832 N  N   . PRO B 1 333 ? -24.765 -31.972 -17.278 1.00 25.10 ? 338 PRO B N   1 
ATOM   4833 C  CA  . PRO B 1 333 ? -25.587 -32.590 -18.307 1.00 25.47 ? 338 PRO B CA  1 
ATOM   4834 C  C   . PRO B 1 333 ? -25.165 -32.050 -19.664 1.00 26.63 ? 338 PRO B C   1 
ATOM   4835 O  O   . PRO B 1 333 ? -24.638 -30.928 -19.740 1.00 24.60 ? 338 PRO B O   1 
ATOM   4836 C  CB  . PRO B 1 333 ? -26.992 -32.083 -17.998 1.00 25.22 ? 338 PRO B CB  1 
ATOM   4837 C  CG  . PRO B 1 333 ? -26.795 -30.866 -17.139 1.00 24.94 ? 338 PRO B CG  1 
ATOM   4838 C  CD  . PRO B 1 333 ? -25.555 -31.136 -16.356 1.00 24.38 ? 338 PRO B CD  1 
ATOM   4839 N  N   . THR B 1 334 ? -25.420 -32.840 -20.708 1.00 26.86 ? 339 THR B N   1 
ATOM   4840 C  CA  . THR B 1 334 ? -25.028 -32.500 -22.064 1.00 28.20 ? 339 THR B CA  1 
ATOM   4841 C  C   . THR B 1 334 ? -26.239 -32.561 -23.010 1.00 29.16 ? 339 THR B C   1 
ATOM   4842 O  O   . THR B 1 334 ? -27.139 -33.417 -22.845 1.00 27.92 ? 339 THR B O   1 
ATOM   4843 C  CB  . THR B 1 334 ? -23.919 -33.418 -22.569 1.00 29.41 ? 339 THR B CB  1 
ATOM   4844 O  OG1 . THR B 1 334 ? -24.352 -34.780 -22.480 1.00 30.92 ? 339 THR B OG1 1 
ATOM   4845 C  CG2 . THR B 1 334 ? -22.642 -33.253 -21.743 1.00 29.12 ? 339 THR B CG2 1 
ATOM   4846 N  N   . PRO B 1 335 ? -26.290 -31.634 -23.990 1.00 29.65 ? 340 PRO B N   1 
ATOM   4847 C  CA  . PRO B 1 335 ? -27.416 -31.634 -24.906 1.00 30.69 ? 340 PRO B CA  1 
ATOM   4848 C  C   . PRO B 1 335 ? -27.212 -32.711 -25.979 1.00 32.45 ? 340 PRO B C   1 
ATOM   4849 O  O   . PRO B 1 335 ? -28.081 -32.910 -26.806 1.00 32.84 ? 340 PRO B O   1 
ATOM   4850 C  CB  . PRO B 1 335 ? -27.366 -30.229 -25.515 1.00 30.89 ? 340 PRO B CB  1 
ATOM   4851 C  CG  . PRO B 1 335 ? -25.947 -29.910 -25.565 1.00 29.17 ? 340 PRO B CG  1 
ATOM   4852 C  CD  . PRO B 1 335 ? -25.304 -30.589 -24.351 1.00 30.08 ? 340 PRO B CD  1 
ATOM   4853 N  N   . SER B 1 336 ? -26.026 -33.316 -25.939 1.00 34.23 ? 341 SER B N   1 
ATOM   4854 C  CA  . SER B 1 336 ? -25.670 -34.657 -26.424 1.00 37.36 ? 341 SER B CA  1 
ATOM   4855 C  C   . SER B 1 336 ? -26.823 -35.593 -26.771 1.00 38.10 ? 341 SER B C   1 
ATOM   4856 O  O   . SER B 1 336 ? -26.660 -36.828 -26.738 1.00 39.38 ? 341 SER B O   1 
ATOM   4857 C  CB  . SER B 1 336 ? -24.805 -35.340 -25.345 1.00 37.00 ? 341 SER B CB  1 
ATOM   4858 O  OG  . SER B 1 336 ? -24.147 -36.502 -25.829 1.00 41.25 ? 341 SER B OG  1 
ATOM   4859 N  N   . PHE C 1 15  ? -12.979 19.514  -14.632 1.00 58.35 ? 20  PHE C N   1 
ATOM   4860 C  CA  . PHE C 1 15  ? -13.223 18.195  -13.977 1.00 58.48 ? 20  PHE C CA  1 
ATOM   4861 C  C   . PHE C 1 15  ? -11.955 17.344  -14.041 1.00 58.04 ? 20  PHE C C   1 
ATOM   4862 O  O   . PHE C 1 15  ? -11.120 17.548  -14.929 1.00 58.37 ? 20  PHE C O   1 
ATOM   4863 C  CB  . PHE C 1 15  ? -14.397 17.476  -14.652 1.00 58.79 ? 20  PHE C CB  1 
ATOM   4864 C  CG  . PHE C 1 15  ? -15.670 18.288  -14.690 1.00 60.02 ? 20  PHE C CG  1 
ATOM   4865 C  CD1 . PHE C 1 15  ? -16.503 18.363  -13.567 1.00 60.80 ? 20  PHE C CD1 1 
ATOM   4866 C  CD2 . PHE C 1 15  ? -16.037 18.983  -15.849 1.00 61.12 ? 20  PHE C CD2 1 
ATOM   4867 C  CE1 . PHE C 1 15  ? -17.684 19.119  -13.598 1.00 61.06 ? 20  PHE C CE1 1 
ATOM   4868 C  CE2 . PHE C 1 15  ? -17.218 19.742  -15.896 1.00 61.21 ? 20  PHE C CE2 1 
ATOM   4869 C  CZ  . PHE C 1 15  ? -18.044 19.810  -14.767 1.00 61.83 ? 20  PHE C CZ  1 
ATOM   4870 N  N   . GLN C 1 16  ? -11.801 16.410  -13.098 1.00 57.35 ? 21  GLN C N   1 
ATOM   4871 C  CA  . GLN C 1 16  ? -10.653 15.492  -13.098 1.00 56.56 ? 21  GLN C CA  1 
ATOM   4872 C  C   . GLN C 1 16  ? -10.497 14.766  -14.439 1.00 55.52 ? 21  GLN C C   1 
ATOM   4873 O  O   . GLN C 1 16  ? -9.396  14.699  -14.988 1.00 55.77 ? 21  GLN C O   1 
ATOM   4874 C  CB  . GLN C 1 16  ? -10.757 14.467  -11.965 1.00 56.94 ? 21  GLN C CB  1 
ATOM   4875 C  CG  . GLN C 1 16  ? -10.520 15.039  -10.585 1.00 58.74 ? 21  GLN C CG  1 
ATOM   4876 C  CD  . GLN C 1 16  ? -9.039  15.262  -10.234 1.00 61.25 ? 21  GLN C CD  1 
ATOM   4877 O  OE1 . GLN C 1 16  ? -8.140  15.085  -11.067 1.00 61.51 ? 21  GLN C OE1 1 
ATOM   4878 N  NE2 . GLN C 1 16  ? -8.790  15.657  -8.977  1.00 61.74 ? 21  GLN C NE2 1 
ATOM   4879 N  N   . SER C 1 17  ? -11.602 14.221  -14.949 1.00 53.82 ? 22  SER C N   1 
ATOM   4880 C  CA  . SER C 1 17  ? -11.630 13.575  -16.266 1.00 51.88 ? 22  SER C CA  1 
ATOM   4881 C  C   . SER C 1 17  ? -13.031 13.632  -16.887 1.00 50.05 ? 22  SER C C   1 
ATOM   4882 O  O   . SER C 1 17  ? -14.052 13.571  -16.177 1.00 49.92 ? 22  SER C O   1 
ATOM   4883 C  CB  . SER C 1 17  ? -11.120 12.124  -16.192 1.00 52.29 ? 22  SER C CB  1 
ATOM   4884 O  OG  . SER C 1 17  ? -11.668 11.431  -15.080 1.00 53.50 ? 22  SER C OG  1 
ATOM   4885 N  N   . VAL C 1 18  ? -13.059 13.768  -18.213 1.00 47.00 ? 23  VAL C N   1 
ATOM   4886 C  CA  . VAL C 1 18  ? -14.299 13.757  -18.990 1.00 44.26 ? 23  VAL C CA  1 
ATOM   4887 C  C   . VAL C 1 18  ? -14.505 12.347  -19.582 1.00 42.59 ? 23  VAL C C   1 
ATOM   4888 O  O   . VAL C 1 18  ? -13.541 11.694  -20.020 1.00 42.71 ? 23  VAL C O   1 
ATOM   4889 C  CB  . VAL C 1 18  ? -14.269 14.853  -20.101 1.00 44.30 ? 23  VAL C CB  1 
ATOM   4890 C  CG1 . VAL C 1 18  ? -15.614 14.963  -20.820 1.00 43.21 ? 23  VAL C CG1 1 
ATOM   4891 C  CG2 . VAL C 1 18  ? -13.866 16.224  -19.505 1.00 44.10 ? 23  VAL C CG2 1 
ATOM   4892 N  N   . HIS C 1 19  ? -15.747 11.870  -19.553 1.00 39.83 ? 24  HIS C N   1 
ATOM   4893 C  CA  . HIS C 1 19  ? -16.107 10.595  -20.172 1.00 37.57 ? 24  HIS C CA  1 
ATOM   4894 C  C   . HIS C 1 19  ? -17.313 10.797  -21.068 1.00 35.80 ? 24  HIS C C   1 
ATOM   4895 O  O   . HIS C 1 19  ? -18.225 11.571  -20.731 1.00 35.61 ? 24  HIS C O   1 
ATOM   4896 C  CB  . HIS C 1 19  ? -16.491 9.540   -19.125 1.00 37.71 ? 24  HIS C CB  1 
ATOM   4897 C  CG  . HIS C 1 19  ? -15.596 9.504   -17.926 1.00 38.41 ? 24  HIS C CG  1 
ATOM   4898 N  ND1 . HIS C 1 19  ? -14.403 8.811   -17.907 1.00 39.25 ? 24  HIS C ND1 1 
ATOM   4899 C  CD2 . HIS C 1 19  ? -15.732 10.055  -16.695 1.00 38.00 ? 24  HIS C CD2 1 
ATOM   4900 C  CE1 . HIS C 1 19  ? -13.836 8.946   -16.721 1.00 39.40 ? 24  HIS C CE1 1 
ATOM   4901 N  NE2 . HIS C 1 19  ? -14.619 9.701   -15.968 1.00 39.57 ? 24  HIS C NE2 1 
ATOM   4902 N  N   . SER C 1 20  ? -17.332 10.076  -22.185 1.00 33.10 ? 25  SER C N   1 
ATOM   4903 C  CA  . SER C 1 20  ? -18.502 10.008  -23.017 1.00 31.16 ? 25  SER C CA  1 
ATOM   4904 C  C   . SER C 1 20  ? -19.299 8.776   -22.643 1.00 30.24 ? 25  SER C C   1 
ATOM   4905 O  O   . SER C 1 20  ? -18.779 7.651   -22.671 1.00 29.72 ? 25  SER C O   1 
ATOM   4906 C  CB  . SER C 1 20  ? -18.123 9.988   -24.501 1.00 31.45 ? 25  SER C CB  1 
ATOM   4907 O  OG  . SER C 1 20  ? -17.456 11.198  -24.822 1.00 33.03 ? 25  SER C OG  1 
ATOM   4908 N  N   . VAL C 1 21  ? -20.563 9.004   -22.301 1.00 28.17 ? 26  VAL C N   1 
ATOM   4909 C  CA  . VAL C 1 21  ? -21.421 7.973   -21.742 1.00 27.37 ? 26  VAL C CA  1 
ATOM   4910 C  C   . VAL C 1 21  ? -22.749 7.902   -22.501 1.00 26.06 ? 26  VAL C C   1 
ATOM   4911 O  O   . VAL C 1 21  ? -23.445 8.899   -22.612 1.00 25.89 ? 26  VAL C O   1 
ATOM   4912 C  CB  . VAL C 1 21  ? -21.717 8.262   -20.243 1.00 26.98 ? 26  VAL C CB  1 
ATOM   4913 C  CG1 . VAL C 1 21  ? -22.625 7.176   -19.663 1.00 27.32 ? 26  VAL C CG1 1 
ATOM   4914 C  CG2 . VAL C 1 21  ? -20.432 8.368   -19.467 1.00 26.23 ? 26  VAL C CG2 1 
ATOM   4915 N  N   . ALA C 1 22  ? -23.082 6.729   -23.026 1.00 25.42 ? 27  ALA C N   1 
ATOM   4916 C  CA  . ALA C 1 22  ? -24.405 6.480   -23.571 1.00 25.59 ? 27  ALA C CA  1 
ATOM   4917 C  C   . ALA C 1 22  ? -25.221 5.767   -22.519 1.00 25.88 ? 27  ALA C C   1 
ATOM   4918 O  O   . ALA C 1 22  ? -24.669 4.966   -21.759 1.00 25.91 ? 27  ALA C O   1 
ATOM   4919 C  CB  . ALA C 1 22  ? -24.321 5.632   -24.803 1.00 25.29 ? 27  ALA C CB  1 
ATOM   4920 N  N   . VAL C 1 23  ? -26.524 6.048   -22.495 1.00 25.65 ? 28  VAL C N   1 
ATOM   4921 C  CA  . VAL C 1 23  ? -27.462 5.458   -21.567 1.00 25.82 ? 28  VAL C CA  1 
ATOM   4922 C  C   . VAL C 1 23  ? -28.573 4.783   -22.362 1.00 26.72 ? 28  VAL C C   1 
ATOM   4923 O  O   . VAL C 1 23  ? -29.294 5.447   -23.128 1.00 26.86 ? 28  VAL C O   1 
ATOM   4924 C  CB  . VAL C 1 23  ? -28.043 6.530   -20.604 1.00 25.57 ? 28  VAL C CB  1 
ATOM   4925 C  CG1 . VAL C 1 23  ? -29.181 5.971   -19.759 1.00 26.63 ? 28  VAL C CG1 1 
ATOM   4926 C  CG2 . VAL C 1 23  ? -26.969 7.086   -19.705 1.00 25.75 ? 28  VAL C CG2 1 
ATOM   4927 N  N   . ILE C 1 24  ? -28.719 3.468   -22.182 1.00 26.99 ? 29  ILE C N   1 
ATOM   4928 C  CA  . ILE C 1 24  ? -29.808 2.705   -22.789 1.00 27.04 ? 29  ILE C CA  1 
ATOM   4929 C  C   . ILE C 1 24  ? -30.709 2.108   -21.710 1.00 27.88 ? 29  ILE C C   1 
ATOM   4930 O  O   . ILE C 1 24  ? -30.239 1.387   -20.808 1.00 27.18 ? 29  ILE C O   1 
ATOM   4931 C  CB  . ILE C 1 24  ? -29.289 1.528   -23.641 1.00 26.96 ? 29  ILE C CB  1 
ATOM   4932 C  CG1 . ILE C 1 24  ? -28.270 1.988   -24.677 1.00 28.08 ? 29  ILE C CG1 1 
ATOM   4933 C  CG2 . ILE C 1 24  ? -30.448 0.780   -24.274 1.00 27.29 ? 29  ILE C CG2 1 
ATOM   4934 C  CD1 . ILE C 1 24  ? -27.309 0.876   -25.117 1.00 30.21 ? 29  ILE C CD1 1 
ATOM   4935 N  N   . GLY C 1 25  ? -32.004 2.390   -21.793 1.00 27.66 ? 30  GLY C N   1 
ATOM   4936 C  CA  . GLY C 1 25  ? -32.958 1.716   -20.927 1.00 28.53 ? 30  GLY C CA  1 
ATOM   4937 C  C   . GLY C 1 25  ? -33.384 0.427   -21.569 1.00 29.45 ? 30  GLY C C   1 
ATOM   4938 O  O   . GLY C 1 25  ? -33.771 0.416   -22.763 1.00 30.09 ? 30  GLY C O   1 
ATOM   4939 N  N   . ALA C 1 26  ? -33.313 -0.668  -20.810 1.00 29.83 ? 31  ALA C N   1 
ATOM   4940 C  CA  . ALA C 1 26  ? -33.825 -1.965  -21.273 1.00 30.72 ? 31  ALA C CA  1 
ATOM   4941 C  C   . ALA C 1 26  ? -34.929 -2.506  -20.357 1.00 31.64 ? 31  ALA C C   1 
ATOM   4942 O  O   . ALA C 1 26  ? -34.669 -3.357  -19.499 1.00 31.65 ? 31  ALA C O   1 
ATOM   4943 C  CB  . ALA C 1 26  ? -32.691 -2.985  -21.421 1.00 30.99 ? 31  ALA C CB  1 
ATOM   4944 N  N   . PRO C 1 27  ? -36.170 -2.008  -20.528 1.00 32.53 ? 32  PRO C N   1 
ATOM   4945 C  CA  . PRO C 1 27  ? -37.256 -2.396  -19.629 1.00 32.69 ? 32  PRO C CA  1 
ATOM   4946 C  C   . PRO C 1 27  ? -37.753 -3.817  -19.898 1.00 33.38 ? 32  PRO C C   1 
ATOM   4947 O  O   . PRO C 1 27  ? -38.834 -3.985  -20.453 1.00 34.63 ? 32  PRO C O   1 
ATOM   4948 C  CB  . PRO C 1 27  ? -38.354 -1.360  -19.927 1.00 33.17 ? 32  PRO C CB  1 
ATOM   4949 C  CG  . PRO C 1 27  ? -38.058 -0.852  -21.296 1.00 33.46 ? 32  PRO C CG  1 
ATOM   4950 C  CD  . PRO C 1 27  ? -36.579 -0.967  -21.496 1.00 31.99 ? 32  PRO C CD  1 
ATOM   4951 N  N   . PHE C 1 28  ? -36.995 -4.825  -19.473 1.00 32.64 ? 33  PHE C N   1 
ATOM   4952 C  CA  . PHE C 1 28  ? -37.313 -6.210  -19.800 1.00 33.25 ? 33  PHE C CA  1 
ATOM   4953 C  C   . PHE C 1 28  ? -37.453 -7.097  -18.550 1.00 32.74 ? 33  PHE C C   1 
ATOM   4954 O  O   . PHE C 1 28  ? -36.664 -6.978  -17.605 1.00 32.53 ? 33  PHE C O   1 
ATOM   4955 C  CB  . PHE C 1 28  ? -36.257 -6.760  -20.756 1.00 33.34 ? 33  PHE C CB  1 
ATOM   4956 C  CG  . PHE C 1 28  ? -36.620 -8.080  -21.375 1.00 35.09 ? 33  PHE C CG  1 
ATOM   4957 C  CD1 . PHE C 1 28  ? -37.763 -8.204  -22.184 1.00 35.80 ? 33  PHE C CD1 1 
ATOM   4958 C  CD2 . PHE C 1 28  ? -35.814 -9.212  -21.151 1.00 35.60 ? 33  PHE C CD2 1 
ATOM   4959 C  CE1 . PHE C 1 28  ? -38.110 -9.424  -22.759 1.00 36.10 ? 33  PHE C CE1 1 
ATOM   4960 C  CE2 . PHE C 1 28  ? -36.141 -10.442 -21.721 1.00 35.24 ? 33  PHE C CE2 1 
ATOM   4961 C  CZ  . PHE C 1 28  ? -37.291 -10.553 -22.536 1.00 36.90 ? 33  PHE C CZ  1 
ATOM   4962 N  N   . SER C 1 29  ? -38.462 -7.969  -18.549 1.00 31.97 ? 34  SER C N   1 
ATOM   4963 C  CA  . SER C 1 29  ? -38.831 -8.738  -17.355 1.00 30.90 ? 34  SER C CA  1 
ATOM   4964 C  C   . SER C 1 29  ? -38.876 -10.251 -17.573 1.00 30.60 ? 34  SER C C   1 
ATOM   4965 O  O   . SER C 1 29  ? -38.904 -11.014 -16.611 1.00 30.12 ? 34  SER C O   1 
ATOM   4966 C  CB  . SER C 1 29  ? -40.173 -8.232  -16.788 1.00 31.82 ? 34  SER C CB  1 
ATOM   4967 O  OG  . SER C 1 29  ? -41.274 -8.614  -17.608 1.00 32.55 ? 34  SER C OG  1 
ATOM   4968 N  N   . GLN C 1 30  ? -38.853 -10.690 -18.832 1.00 30.78 ? 35  GLN C N   1 
ATOM   4969 C  CA  . GLN C 1 30  ? -39.095 -12.102 -19.150 1.00 31.05 ? 35  GLN C CA  1 
ATOM   4970 C  C   . GLN C 1 30  ? -37.962 -13.101 -18.901 1.00 30.48 ? 35  GLN C C   1 
ATOM   4971 O  O   . GLN C 1 30  ? -38.106 -14.312 -19.196 1.00 30.14 ? 35  GLN C O   1 
ATOM   4972 C  CB  . GLN C 1 30  ? -39.648 -12.224 -20.564 1.00 32.21 ? 35  GLN C CB  1 
ATOM   4973 C  CG  . GLN C 1 30  ? -41.073 -11.675 -20.630 1.00 35.86 ? 35  GLN C CG  1 
ATOM   4974 C  CD  . GLN C 1 30  ? -41.726 -11.924 -21.953 1.00 41.97 ? 35  GLN C CD  1 
ATOM   4975 O  OE1 . GLN C 1 30  ? -41.602 -11.116 -22.872 1.00 45.27 ? 35  GLN C OE1 1 
ATOM   4976 N  NE2 . GLN C 1 30  ? -42.438 -13.039 -22.065 1.00 43.42 ? 35  GLN C NE2 1 
ATOM   4977 N  N   . GLY C 1 31  ? -36.837 -12.615 -18.366 1.00 29.81 ? 36  GLY C N   1 
ATOM   4978 C  CA  . GLY C 1 31  ? -35.793 -13.520 -17.870 1.00 29.34 ? 36  GLY C CA  1 
ATOM   4979 C  C   . GLY C 1 31  ? -36.165 -14.063 -16.501 1.00 29.77 ? 36  GLY C C   1 
ATOM   4980 O  O   . GLY C 1 31  ? -35.429 -14.875 -15.929 1.00 28.86 ? 36  GLY C O   1 
ATOM   4981 N  N   . GLN C 1 32  ? -37.316 -13.617 -15.972 1.00 29.98 ? 37  GLN C N   1 
ATOM   4982 C  CA  . GLN C 1 32  ? -37.800 -14.060 -14.660 1.00 30.53 ? 37  GLN C CA  1 
ATOM   4983 C  C   . GLN C 1 32  ? -39.335 -13.964 -14.548 1.00 31.89 ? 37  GLN C C   1 
ATOM   4984 O  O   . GLN C 1 32  ? -40.002 -13.684 -15.544 1.00 32.19 ? 37  GLN C O   1 
ATOM   4985 C  CB  . GLN C 1 32  ? -37.061 -13.324 -13.528 1.00 30.27 ? 37  GLN C CB  1 
ATOM   4986 C  CG  . GLN C 1 32  ? -37.008 -11.840 -13.686 1.00 28.33 ? 37  GLN C CG  1 
ATOM   4987 C  CD  . GLN C 1 32  ? -38.213 -11.192 -13.085 1.00 29.71 ? 37  GLN C CD  1 
ATOM   4988 O  OE1 . GLN C 1 32  ? -38.387 -11.216 -11.871 1.00 30.82 ? 37  GLN C OE1 1 
ATOM   4989 N  NE2 . GLN C 1 32  ? -39.067 -10.610 -13.926 1.00 31.09 ? 37  GLN C NE2 1 
ATOM   4990 N  N   . LYS C 1 33  ? -39.897 -14.204 -13.366 1.00 32.81 ? 38  LYS C N   1 
ATOM   4991 C  CA  . LYS C 1 33  ? -41.368 -14.405 -13.281 1.00 34.45 ? 38  LYS C CA  1 
ATOM   4992 C  C   . LYS C 1 33  ? -42.105 -13.323 -12.505 1.00 35.08 ? 38  LYS C C   1 
ATOM   4993 O  O   . LYS C 1 33  ? -43.336 -13.222 -12.593 1.00 35.83 ? 38  LYS C O   1 
ATOM   4994 C  CB  . LYS C 1 33  ? -41.696 -15.786 -12.691 1.00 34.78 ? 38  LYS C CB  1 
ATOM   4995 C  CG  . LYS C 1 33  ? -41.564 -16.966 -13.655 1.00 36.61 ? 38  LYS C CG  1 
ATOM   4996 C  CD  . LYS C 1 33  ? -41.851 -18.281 -12.914 1.00 39.60 ? 38  LYS C CD  1 
ATOM   4997 C  CE  . LYS C 1 33  ? -41.453 -19.519 -13.721 1.00 40.77 ? 38  LYS C CE  1 
ATOM   4998 N  NZ  . LYS C 1 33  ? -40.097 -20.035 -13.346 1.00 41.66 ? 38  LYS C NZ  1 
ATOM   4999 N  N   . ARG C 1 34  ? -41.362 -12.523 -11.741 1.00 35.52 ? 39  ARG C N   1 
ATOM   5000 C  CA  . ARG C 1 34  ? -41.939 -11.456 -10.926 1.00 35.67 ? 39  ARG C CA  1 
ATOM   5001 C  C   . ARG C 1 34  ? -42.100 -10.191 -11.738 1.00 35.40 ? 39  ARG C C   1 
ATOM   5002 O  O   . ARG C 1 34  ? -41.175 -9.772  -12.422 1.00 34.90 ? 39  ARG C O   1 
ATOM   5003 C  CB  . ARG C 1 34  ? -41.070 -11.198 -9.695  1.00 35.86 ? 39  ARG C CB  1 
ATOM   5004 C  CG  . ARG C 1 34  ? -40.773 -12.481 -8.918  1.00 37.40 ? 39  ARG C CG  1 
ATOM   5005 C  CD  . ARG C 1 34  ? -41.218 -12.337 -7.482  1.00 42.40 ? 39  ARG C CD  1 
ATOM   5006 N  NE  . ARG C 1 34  ? -40.132 -12.077 -6.550  1.00 44.74 ? 39  ARG C NE  1 
ATOM   5007 C  CZ  . ARG C 1 34  ? -40.305 -11.725 -5.275  1.00 46.91 ? 39  ARG C CZ  1 
ATOM   5008 N  NH1 . ARG C 1 34  ? -41.526 -11.556 -4.770  1.00 46.22 ? 39  ARG C NH1 1 
ATOM   5009 N  NH2 . ARG C 1 34  ? -39.250 -11.522 -4.499  1.00 46.75 ? 39  ARG C NH2 1 
ATOM   5010 N  N   . LYS C 1 35  ? -43.287 -9.589  -11.677 1.00 34.90 ? 40  LYS C N   1 
ATOM   5011 C  CA  . LYS C 1 35  ? -43.547 -8.368  -12.451 1.00 34.44 ? 40  LYS C CA  1 
ATOM   5012 C  C   . LYS C 1 35  ? -42.952 -7.099  -11.813 1.00 33.30 ? 40  LYS C C   1 
ATOM   5013 O  O   . LYS C 1 35  ? -42.786 -7.025  -10.600 1.00 32.81 ? 40  LYS C O   1 
ATOM   5014 C  CB  . LYS C 1 35  ? -45.051 -8.225  -12.782 1.00 34.94 ? 40  LYS C CB  1 
ATOM   5015 C  CG  . LYS C 1 35  ? -46.002 -8.868  -11.787 1.00 38.19 ? 40  LYS C CG  1 
ATOM   5016 C  CD  . LYS C 1 35  ? -47.316 -9.339  -12.466 1.00 41.70 ? 40  LYS C CD  1 
ATOM   5017 C  CE  . LYS C 1 35  ? -47.317 -10.843 -12.654 1.00 43.27 ? 40  LYS C CE  1 
ATOM   5018 N  NZ  . LYS C 1 35  ? -48.579 -11.360 -13.237 1.00 44.46 ? 40  LYS C NZ  1 
ATOM   5019 N  N   . GLY C 1 36  ? -42.583 -6.134  -12.654 1.00 32.52 ? 41  GLY C N   1 
ATOM   5020 C  CA  . GLY C 1 36  ? -42.192 -4.800  -12.209 1.00 31.01 ? 41  GLY C CA  1 
ATOM   5021 C  C   . GLY C 1 36  ? -40.765 -4.349  -12.480 1.00 30.43 ? 41  GLY C C   1 
ATOM   5022 O  O   . GLY C 1 36  ? -40.485 -3.135  -12.460 1.00 29.68 ? 41  GLY C O   1 
ATOM   5023 N  N   . VAL C 1 37  ? -39.860 -5.313  -12.715 1.00 29.97 ? 42  VAL C N   1 
ATOM   5024 C  CA  . VAL C 1 37  ? -38.447 -4.996  -13.021 1.00 29.30 ? 42  VAL C CA  1 
ATOM   5025 C  C   . VAL C 1 37  ? -38.329 -4.236  -14.353 1.00 29.53 ? 42  VAL C C   1 
ATOM   5026 O  O   . VAL C 1 37  ? -37.351 -3.536  -14.573 1.00 28.84 ? 42  VAL C O   1 
ATOM   5027 C  CB  . VAL C 1 37  ? -37.512 -6.260  -12.992 1.00 28.79 ? 42  VAL C CB  1 
ATOM   5028 C  CG1 . VAL C 1 37  ? -37.794 -7.213  -14.176 1.00 28.10 ? 42  VAL C CG1 1 
ATOM   5029 C  CG2 . VAL C 1 37  ? -36.052 -5.854  -12.979 1.00 27.52 ? 42  VAL C CG2 1 
ATOM   5030 N  N   . GLU C 1 38  ? -39.342 -4.367  -15.225 1.00 29.72 ? 43  GLU C N   1 
ATOM   5031 C  CA  . GLU C 1 38  ? -39.428 -3.533  -16.446 1.00 29.70 ? 43  GLU C CA  1 
ATOM   5032 C  C   . GLU C 1 38  ? -39.474 -2.019  -16.158 1.00 28.85 ? 43  GLU C C   1 
ATOM   5033 O  O   . GLU C 1 38  ? -39.201 -1.204  -17.043 1.00 29.04 ? 43  GLU C O   1 
ATOM   5034 C  CB  . GLU C 1 38  ? -40.627 -3.955  -17.342 1.00 30.37 ? 43  GLU C CB  1 
ATOM   5035 C  CG  . GLU C 1 38  ? -42.011 -3.726  -16.727 1.00 32.23 ? 43  GLU C CG  1 
ATOM   5036 C  CD  . GLU C 1 38  ? -42.542 -4.928  -15.950 1.00 35.88 ? 43  GLU C CD  1 
ATOM   5037 O  OE1 . GLU C 1 38  ? -41.749 -5.710  -15.367 1.00 34.41 ? 43  GLU C OE1 1 
ATOM   5038 O  OE2 . GLU C 1 38  ? -43.781 -5.099  -15.914 1.00 37.61 ? 43  GLU C OE2 1 
ATOM   5039 N  N   . HIS C 1 39  ? -39.850 -1.652  -14.934 1.00 28.79 ? 44  HIS C N   1 
ATOM   5040 C  CA  . HIS C 1 39  ? -39.870 -0.251  -14.480 1.00 28.56 ? 44  HIS C CA  1 
ATOM   5041 C  C   . HIS C 1 39  ? -38.572 0.206   -13.809 1.00 28.21 ? 44  HIS C C   1 
ATOM   5042 O  O   . HIS C 1 39  ? -38.441 1.373   -13.397 1.00 26.96 ? 44  HIS C O   1 
ATOM   5043 C  CB  . HIS C 1 39  ? -41.043 -0.019  -13.527 1.00 29.87 ? 44  HIS C CB  1 
ATOM   5044 C  CG  . HIS C 1 39  ? -42.366 -0.379  -14.120 1.00 31.41 ? 44  HIS C CG  1 
ATOM   5045 N  ND1 . HIS C 1 39  ? -42.858 0.223   -15.259 1.00 35.40 ? 44  HIS C ND1 1 
ATOM   5046 C  CD2 . HIS C 1 39  ? -43.285 -1.300  -13.753 1.00 33.61 ? 44  HIS C CD2 1 
ATOM   5047 C  CE1 . HIS C 1 39  ? -44.035 -0.298  -15.556 1.00 35.80 ? 44  HIS C CE1 1 
ATOM   5048 N  NE2 . HIS C 1 39  ? -44.319 -1.224  -14.657 1.00 36.09 ? 44  HIS C NE2 1 
ATOM   5049 N  N   . GLY C 1 40  ? -37.620 -0.719  -13.699 1.00 27.04 ? 45  GLY C N   1 
ATOM   5050 C  CA  . GLY C 1 40  ? -36.247 -0.362  -13.341 1.00 26.47 ? 45  GLY C CA  1 
ATOM   5051 C  C   . GLY C 1 40  ? -35.664 0.861   -14.013 1.00 25.53 ? 45  GLY C C   1 
ATOM   5052 O  O   . GLY C 1 40  ? -35.247 1.797   -13.333 1.00 25.79 ? 45  GLY C O   1 
ATOM   5053 N  N   . PRO C 1 41  ? -35.593 0.869   -15.360 1.00 25.49 ? 46  PRO C N   1 
ATOM   5054 C  CA  . PRO C 1 41  ? -34.984 2.042   -16.005 1.00 24.72 ? 46  PRO C CA  1 
ATOM   5055 C  C   . PRO C 1 41  ? -35.653 3.381   -15.619 1.00 25.22 ? 46  PRO C C   1 
ATOM   5056 O  O   . PRO C 1 41  ? -34.970 4.384   -15.395 1.00 24.79 ? 46  PRO C O   1 
ATOM   5057 C  CB  . PRO C 1 41  ? -35.156 1.749   -17.491 1.00 24.09 ? 46  PRO C CB  1 
ATOM   5058 C  CG  . PRO C 1 41  ? -35.252 0.275   -17.571 1.00 25.90 ? 46  PRO C CG  1 
ATOM   5059 C  CD  . PRO C 1 41  ? -35.958 -0.172  -16.336 1.00 24.87 ? 46  PRO C CD  1 
ATOM   5060 N  N   . ALA C 1 42  ? -36.980 3.396   -15.543 1.00 25.20 ? 47  ALA C N   1 
ATOM   5061 C  CA  . ALA C 1 42  ? -37.685 4.622   -15.144 1.00 25.79 ? 47  ALA C CA  1 
ATOM   5062 C  C   . ALA C 1 42  ? -37.298 5.055   -13.729 1.00 25.10 ? 47  ALA C C   1 
ATOM   5063 O  O   . ALA C 1 42  ? -36.928 6.207   -13.515 1.00 25.38 ? 47  ALA C O   1 
ATOM   5064 C  CB  . ALA C 1 42  ? -39.219 4.444   -15.264 1.00 25.88 ? 47  ALA C CB  1 
ATOM   5065 N  N   . ALA C 1 43  ? -37.351 4.110   -12.788 1.00 24.61 ? 48  ALA C N   1 
ATOM   5066 C  CA  . ALA C 1 43  ? -36.980 4.370   -11.391 1.00 24.40 ? 48  ALA C CA  1 
ATOM   5067 C  C   . ALA C 1 43  ? -35.602 5.002   -11.274 1.00 24.70 ? 48  ALA C C   1 
ATOM   5068 O  O   . ALA C 1 43  ? -35.425 6.038   -10.596 1.00 24.75 ? 48  ALA C O   1 
ATOM   5069 C  CB  . ALA C 1 43  ? -37.052 3.096   -10.573 1.00 24.34 ? 48  ALA C CB  1 
ATOM   5070 N  N   . ILE C 1 44  ? -34.618 4.391   -11.935 1.00 25.02 ? 49  ILE C N   1 
ATOM   5071 C  CA  . ILE C 1 44  ? -33.243 4.914   -11.898 1.00 24.81 ? 49  ILE C CA  1 
ATOM   5072 C  C   . ILE C 1 44  ? -33.194 6.340   -12.500 1.00 25.95 ? 49  ILE C C   1 
ATOM   5073 O  O   . ILE C 1 44  ? -32.517 7.228   -11.974 1.00 25.63 ? 49  ILE C O   1 
ATOM   5074 C  CB  . ILE C 1 44  ? -32.251 3.930   -12.597 1.00 23.76 ? 49  ILE C CB  1 
ATOM   5075 C  CG1 . ILE C 1 44  ? -32.215 2.579   -11.838 1.00 21.72 ? 49  ILE C CG1 1 
ATOM   5076 C  CG2 . ILE C 1 44  ? -30.872 4.574   -12.737 1.00 24.18 ? 49  ILE C CG2 1 
ATOM   5077 C  CD1 . ILE C 1 44  ? -31.610 1.371   -12.631 1.00 23.02 ? 49  ILE C CD1 1 
ATOM   5078 N  N   . ARG C 1 45  ? -33.904 6.548   -13.612 1.00 27.40 ? 50  ARG C N   1 
ATOM   5079 C  CA  . ARG C 1 45  ? -33.957 7.873   -14.250 1.00 28.56 ? 50  ARG C CA  1 
ATOM   5080 C  C   . ARG C 1 45  ? -34.546 8.931   -13.326 1.00 29.14 ? 50  ARG C C   1 
ATOM   5081 O  O   . ARG C 1 45  ? -33.969 10.007  -13.198 1.00 29.82 ? 50  ARG C O   1 
ATOM   5082 C  CB  . ARG C 1 45  ? -34.752 7.817   -15.559 1.00 28.60 ? 50  ARG C CB  1 
ATOM   5083 C  CG  . ARG C 1 45  ? -33.987 7.231   -16.758 1.00 29.01 ? 50  ARG C CG  1 
ATOM   5084 C  CD  . ARG C 1 45  ? -34.923 7.144   -17.976 1.00 31.25 ? 50  ARG C CD  1 
ATOM   5085 N  NE  . ARG C 1 45  ? -34.352 6.433   -19.127 1.00 31.62 ? 50  ARG C NE  1 
ATOM   5086 C  CZ  . ARG C 1 45  ? -33.440 6.948   -19.946 1.00 31.06 ? 50  ARG C CZ  1 
ATOM   5087 N  NH1 . ARG C 1 45  ? -32.983 8.174   -19.732 1.00 30.45 ? 50  ARG C NH1 1 
ATOM   5088 N  NH2 . ARG C 1 45  ? -32.989 6.236   -20.980 1.00 30.03 ? 50  ARG C NH2 1 
ATOM   5089 N  N   . GLU C 1 46  ? -35.691 8.613   -12.697 1.00 30.01 ? 51  GLU C N   1 
ATOM   5090 C  CA  . GLU C 1 46  ? -36.380 9.504   -11.745 1.00 31.15 ? 51  GLU C CA  1 
ATOM   5091 C  C   . GLU C 1 46  ? -35.563 9.813   -10.487 1.00 31.21 ? 51  GLU C C   1 
ATOM   5092 O  O   . GLU C 1 46  ? -35.697 10.898  -9.896  1.00 31.51 ? 51  GLU C O   1 
ATOM   5093 C  CB  . GLU C 1 46  ? -37.758 8.928   -11.384 1.00 31.72 ? 51  GLU C CB  1 
ATOM   5094 C  CG  . GLU C 1 46  ? -38.653 8.779   -12.615 1.00 34.90 ? 51  GLU C CG  1 
ATOM   5095 C  CD  . GLU C 1 46  ? -39.913 7.980   -12.367 1.00 39.84 ? 51  GLU C CD  1 
ATOM   5096 O  OE1 . GLU C 1 46  ? -40.160 7.580   -11.209 1.00 41.50 ? 51  GLU C OE1 1 
ATOM   5097 O  OE2 . GLU C 1 46  ? -40.660 7.748   -13.349 1.00 41.96 ? 51  GLU C OE2 1 
ATOM   5098 N  N   . ALA C 1 47  ? -34.686 8.883   -10.103 1.00 30.01 ? 52  ALA C N   1 
ATOM   5099 C  CA  . ALA C 1 47  ? -33.695 9.146   -9.072  1.00 29.30 ? 52  ALA C CA  1 
ATOM   5100 C  C   . ALA C 1 47  ? -32.584 10.098  -9.537  1.00 29.02 ? 52  ALA C C   1 
ATOM   5101 O  O   . ALA C 1 47  ? -31.653 10.392  -8.782  1.00 29.17 ? 52  ALA C O   1 
ATOM   5102 C  CB  . ALA C 1 47  ? -33.103 7.833   -8.576  1.00 28.87 ? 52  ALA C CB  1 
ATOM   5103 N  N   . GLY C 1 48  ? -32.646 10.556  -10.783 1.00 29.30 ? 53  GLY C N   1 
ATOM   5104 C  CA  . GLY C 1 48  ? -31.763 11.651  -11.228 1.00 27.95 ? 53  GLY C CA  1 
ATOM   5105 C  C   . GLY C 1 48  ? -30.456 11.281  -11.912 1.00 27.46 ? 53  GLY C C   1 
ATOM   5106 O  O   . GLY C 1 48  ? -29.493 12.062  -11.878 1.00 26.75 ? 53  GLY C O   1 
ATOM   5107 N  N   . LEU C 1 49  ? -30.426 10.117  -12.567 1.00 26.85 ? 54  LEU C N   1 
ATOM   5108 C  CA  . LEU C 1 49  ? -29.183 9.626   -13.167 1.00 26.70 ? 54  LEU C CA  1 
ATOM   5109 C  C   . LEU C 1 49  ? -28.495 10.642  -14.098 1.00 27.30 ? 54  LEU C C   1 
ATOM   5110 O  O   . LEU C 1 49  ? -27.296 10.946  -13.927 1.00 26.75 ? 54  LEU C O   1 
ATOM   5111 C  CB  . LEU C 1 49  ? -29.374 8.266   -13.860 1.00 25.67 ? 54  LEU C CB  1 
ATOM   5112 C  CG  . LEU C 1 49  ? -28.184 7.754   -14.681 1.00 25.02 ? 54  LEU C CG  1 
ATOM   5113 C  CD1 . LEU C 1 49  ? -27.017 7.413   -13.720 1.00 22.68 ? 54  LEU C CD1 1 
ATOM   5114 C  CD2 . LEU C 1 49  ? -28.591 6.554   -15.529 1.00 23.91 ? 54  LEU C CD2 1 
ATOM   5115 N  N   . MET C 1 50  ? -29.247 11.199  -15.045 1.00 28.11 ? 55  MET C N   1 
ATOM   5116 C  CA  . MET C 1 50  ? -28.635 12.074  -16.078 1.00 29.38 ? 55  MET C CA  1 
ATOM   5117 C  C   . MET C 1 50  ? -27.998 13.342  -15.506 1.00 29.37 ? 55  MET C C   1 
ATOM   5118 O  O   . MET C 1 50  ? -26.839 13.680  -15.817 1.00 29.67 ? 55  MET C O   1 
ATOM   5119 C  CB  . MET C 1 50  ? -29.639 12.379  -17.212 1.00 29.51 ? 55  MET C CB  1 
ATOM   5120 C  CG  . MET C 1 50  ? -30.199 11.128  -17.924 1.00 30.86 ? 55  MET C CG  1 
ATOM   5121 S  SD  . MET C 1 50  ? -28.901 9.955   -18.490 1.00 35.99 ? 55  MET C SD  1 
ATOM   5122 C  CE  . MET C 1 50  ? -28.243 10.772  -19.943 1.00 34.77 ? 55  MET C CE  1 
ATOM   5123 N  N   . LYS C 1 51  ? -28.743 14.009  -14.623 1.00 30.25 ? 56  LYS C N   1 
ATOM   5124 C  CA  . LYS C 1 51  ? -28.243 15.156  -13.880 1.00 30.52 ? 56  LYS C CA  1 
ATOM   5125 C  C   . LYS C 1 51  ? -26.932 14.842  -13.133 1.00 29.64 ? 56  LYS C C   1 
ATOM   5126 O  O   . LYS C 1 51  ? -25.975 15.621  -13.194 1.00 29.30 ? 56  LYS C O   1 
ATOM   5127 C  CB  . LYS C 1 51  ? -29.329 15.646  -12.920 1.00 31.58 ? 56  LYS C CB  1 
ATOM   5128 C  CG  . LYS C 1 51  ? -28.987 16.927  -12.133 1.00 35.97 ? 56  LYS C CG  1 
ATOM   5129 C  CD  . LYS C 1 51  ? -29.342 18.212  -12.908 1.00 40.67 ? 56  LYS C CD  1 
ATOM   5130 C  CE  . LYS C 1 51  ? -29.095 19.458  -12.055 1.00 41.79 ? 56  LYS C CE  1 
ATOM   5131 N  NZ  . LYS C 1 51  ? -29.243 20.712  -12.850 1.00 44.91 ? 56  LYS C NZ  1 
ATOM   5132 N  N   . ARG C 1 52  ? -26.876 13.683  -12.467 1.00 29.19 ? 57  ARG C N   1 
ATOM   5133 C  CA  . ARG C 1 52  ? -25.687 13.284  -11.714 1.00 28.37 ? 57  ARG C CA  1 
ATOM   5134 C  C   . ARG C 1 52  ? -24.490 13.072  -12.636 1.00 27.91 ? 57  ARG C C   1 
ATOM   5135 O  O   . ARG C 1 52  ? -23.412 13.565  -12.352 1.00 27.18 ? 57  ARG C O   1 
ATOM   5136 C  CB  . ARG C 1 52  ? -25.952 12.025  -10.863 1.00 28.84 ? 57  ARG C CB  1 
ATOM   5137 C  CG  . ARG C 1 52  ? -24.743 11.617  -10.029 1.00 29.59 ? 57  ARG C CG  1 
ATOM   5138 C  CD  . ARG C 1 52  ? -24.617 12.413  -8.704  1.00 32.16 ? 57  ARG C CD  1 
ATOM   5139 N  NE  . ARG C 1 52  ? -25.782 12.181  -7.856  1.00 32.03 ? 57  ARG C NE  1 
ATOM   5140 C  CZ  . ARG C 1 52  ? -25.974 11.116  -7.084  1.00 31.11 ? 57  ARG C CZ  1 
ATOM   5141 N  NH1 . ARG C 1 52  ? -27.098 11.013  -6.389  1.00 30.94 ? 57  ARG C NH1 1 
ATOM   5142 N  NH2 . ARG C 1 52  ? -25.079 10.152  -7.015  1.00 31.11 ? 57  ARG C NH2 1 
ATOM   5143 N  N   . LEU C 1 53  ? -24.691 12.348  -13.741 1.00 27.76 ? 58  LEU C N   1 
ATOM   5144 C  CA  . LEU C 1 53  ? -23.621 12.158  -14.730 1.00 27.98 ? 58  LEU C CA  1 
ATOM   5145 C  C   . LEU C 1 53  ? -23.198 13.490  -15.385 1.00 28.39 ? 58  LEU C C   1 
ATOM   5146 O  O   . LEU C 1 53  ? -22.008 13.722  -15.598 1.00 28.11 ? 58  LEU C O   1 
ATOM   5147 C  CB  . LEU C 1 53  ? -24.036 11.115  -15.777 1.00 27.42 ? 58  LEU C CB  1 
ATOM   5148 C  CG  . LEU C 1 53  ? -24.327 9.714   -15.227 1.00 28.25 ? 58  LEU C CG  1 
ATOM   5149 C  CD1 . LEU C 1 53  ? -24.768 8.756   -16.339 1.00 27.32 ? 58  LEU C CD1 1 
ATOM   5150 C  CD2 . LEU C 1 53  ? -23.097 9.169   -14.492 1.00 27.79 ? 58  LEU C CD2 1 
ATOM   5151 N  N   . SER C 1 54  ? -24.166 14.373  -15.663 1.00 29.72 ? 59  SER C N   1 
ATOM   5152 C  CA  . SER C 1 54  ? -23.831 15.740  -16.147 1.00 31.06 ? 59  SER C CA  1 
ATOM   5153 C  C   . SER C 1 54  ? -22.922 16.491  -15.185 1.00 31.21 ? 59  SER C C   1 
ATOM   5154 O  O   . SER C 1 54  ? -21.865 17.005  -15.579 1.00 31.46 ? 59  SER C O   1 
ATOM   5155 C  CB  . SER C 1 54  ? -25.091 16.565  -16.389 1.00 31.46 ? 59  SER C CB  1 
ATOM   5156 O  OG  . SER C 1 54  ? -25.845 15.998  -17.438 1.00 35.18 ? 59  SER C OG  1 
ATOM   5157 N  N   . SER C 1 55  ? -23.321 16.514  -13.914 1.00 31.62 ? 60  SER C N   1 
ATOM   5158 C  CA  . SER C 1 55  ? -22.598 17.258  -12.878 1.00 32.05 ? 60  SER C CA  1 
ATOM   5159 C  C   . SER C 1 55  ? -21.155 16.783  -12.720 1.00 31.47 ? 60  SER C C   1 
ATOM   5160 O  O   . SER C 1 55  ? -20.312 17.516  -12.214 1.00 30.91 ? 60  SER C O   1 
ATOM   5161 C  CB  . SER C 1 55  ? -23.343 17.158  -11.539 1.00 32.73 ? 60  SER C CB  1 
ATOM   5162 O  OG  . SER C 1 55  ? -23.202 15.851  -10.986 1.00 35.76 ? 60  SER C OG  1 
ATOM   5163 N  N   . LEU C 1 56  ? -20.880 15.549  -13.151 1.00 31.66 ? 61  LEU C N   1 
ATOM   5164 C  CA  . LEU C 1 56  ? -19.545 14.959  -13.065 1.00 31.27 ? 61  LEU C CA  1 
ATOM   5165 C  C   . LEU C 1 56  ? -18.660 15.231  -14.279 1.00 31.85 ? 61  LEU C C   1 
ATOM   5166 O  O   . LEU C 1 56  ? -17.496 14.854  -14.275 1.00 31.30 ? 61  LEU C O   1 
ATOM   5167 C  CB  . LEU C 1 56  ? -19.630 13.428  -12.841 1.00 31.60 ? 61  LEU C CB  1 
ATOM   5168 C  CG  . LEU C 1 56  ? -20.175 12.889  -11.514 1.00 31.47 ? 61  LEU C CG  1 
ATOM   5169 C  CD1 . LEU C 1 56  ? -20.441 11.386  -11.618 1.00 30.60 ? 61  LEU C CD1 1 
ATOM   5170 C  CD2 . LEU C 1 56  ? -19.240 13.169  -10.343 1.00 27.51 ? 61  LEU C CD2 1 
ATOM   5171 N  N   . GLY C 1 57  ? -19.201 15.891  -15.307 1.00 32.20 ? 62  GLY C N   1 
ATOM   5172 C  CA  . GLY C 1 57  ? -18.426 16.204  -16.518 1.00 31.82 ? 62  GLY C CA  1 
ATOM   5173 C  C   . GLY C 1 57  ? -18.639 15.258  -17.694 1.00 32.13 ? 62  GLY C C   1 
ATOM   5174 O  O   . GLY C 1 57  ? -17.923 15.350  -18.694 1.00 32.34 ? 62  GLY C O   1 
ATOM   5175 N  N   . CYS C 1 58  ? -19.619 14.358  -17.591 1.00 31.72 ? 63  CYS C N   1 
ATOM   5176 C  CA  . CYS C 1 58  ? -19.903 13.397  -18.657 1.00 31.84 ? 63  CYS C CA  1 
ATOM   5177 C  C   . CYS C 1 58  ? -20.558 13.994  -19.913 1.00 31.95 ? 63  CYS C C   1 
ATOM   5178 O  O   . CYS C 1 58  ? -21.607 14.653  -19.832 1.00 32.17 ? 63  CYS C O   1 
ATOM   5179 C  CB  . CYS C 1 58  ? -20.788 12.248  -18.154 1.00 31.57 ? 63  CYS C CB  1 
ATOM   5180 S  SG  . CYS C 1 58  ? -19.996 11.210  -16.896 1.00 31.74 ? 63  CYS C SG  1 
ATOM   5181 N  N   . HIS C 1 59  ? -19.964 13.703  -21.070 1.00 31.71 ? 64  HIS C N   1 
ATOM   5182 C  CA  . HIS C 1 59  ? -20.628 13.921  -22.359 1.00 31.78 ? 64  HIS C CA  1 
ATOM   5183 C  C   . HIS C 1 59  ? -21.645 12.794  -22.532 1.00 31.41 ? 64  HIS C C   1 
ATOM   5184 O  O   . HIS C 1 59  ? -21.277 11.609  -22.612 1.00 31.28 ? 64  HIS C O   1 
ATOM   5185 C  CB  . HIS C 1 59  ? -19.601 13.939  -23.497 1.00 32.09 ? 64  HIS C CB  1 
ATOM   5186 C  CG  . HIS C 1 59  ? -20.213 13.987  -24.869 1.00 34.54 ? 64  HIS C CG  1 
ATOM   5187 N  ND1 . HIS C 1 59  ? -20.694 15.151  -25.430 1.00 36.15 ? 64  HIS C ND1 1 
ATOM   5188 C  CD2 . HIS C 1 59  ? -20.412 13.015  -25.795 1.00 35.03 ? 64  HIS C CD2 1 
ATOM   5189 C  CE1 . HIS C 1 59  ? -21.163 14.893  -26.641 1.00 37.78 ? 64  HIS C CE1 1 
ATOM   5190 N  NE2 . HIS C 1 59  ? -21.006 13.603  -26.885 1.00 36.49 ? 64  HIS C NE2 1 
ATOM   5191 N  N   . LEU C 1 60  ? -22.918 13.152  -22.546 1.00 30.72 ? 65  LEU C N   1 
ATOM   5192 C  CA  . LEU C 1 60  ? -23.980 12.158  -22.456 1.00 31.45 ? 65  LEU C CA  1 
ATOM   5193 C  C   . LEU C 1 60  ? -24.722 11.959  -23.770 1.00 31.73 ? 65  LEU C C   1 
ATOM   5194 O  O   . LEU C 1 60  ? -24.984 12.932  -24.475 1.00 32.29 ? 65  LEU C O   1 
ATOM   5195 C  CB  . LEU C 1 60  ? -25.002 12.561  -21.380 1.00 30.98 ? 65  LEU C CB  1 
ATOM   5196 C  CG  . LEU C 1 60  ? -24.906 12.270  -19.870 1.00 32.43 ? 65  LEU C CG  1 
ATOM   5197 C  CD1 . LEU C 1 60  ? -24.314 10.893  -19.595 1.00 29.24 ? 65  LEU C CD1 1 
ATOM   5198 C  CD2 . LEU C 1 60  ? -24.213 13.327  -19.027 1.00 34.03 ? 65  LEU C CD2 1 
ATOM   5199 N  N   . LYS C 1 61  ? -25.079 10.711  -24.077 1.00 31.46 ? 66  LYS C N   1 
ATOM   5200 C  CA  . LYS C 1 61  ? -26.055 10.407  -25.130 1.00 31.83 ? 66  LYS C CA  1 
ATOM   5201 C  C   . LYS C 1 61  ? -27.127 9.450   -24.616 1.00 31.55 ? 66  LYS C C   1 
ATOM   5202 O  O   . LYS C 1 61  ? -26.829 8.326   -24.189 1.00 30.61 ? 66  LYS C O   1 
ATOM   5203 C  CB  . LYS C 1 61  ? -25.368 9.826   -26.385 1.00 32.11 ? 66  LYS C CB  1 
ATOM   5204 C  CG  . LYS C 1 61  ? -26.334 9.537   -27.533 1.00 33.87 ? 66  LYS C CG  1 
ATOM   5205 C  CD  . LYS C 1 61  ? -25.576 9.211   -28.823 1.00 35.90 ? 66  LYS C CD  1 
ATOM   5206 C  CE  . LYS C 1 61  ? -26.519 8.873   -29.960 1.00 37.56 ? 66  LYS C CE  1 
ATOM   5207 N  NZ  . LYS C 1 61  ? -25.740 8.295   -31.103 1.00 38.70 ? 66  LYS C NZ  1 
ATOM   5208 N  N   . ASP C 1 62  ? -28.375 9.896   -24.654 1.00 31.42 ? 67  ASP C N   1 
ATOM   5209 C  CA  . ASP C 1 62  ? -29.460 9.076   -24.178 1.00 32.33 ? 67  ASP C CA  1 
ATOM   5210 C  C   . ASP C 1 62  ? -30.145 8.411   -25.376 1.00 32.98 ? 67  ASP C C   1 
ATOM   5211 O  O   . ASP C 1 62  ? -30.809 9.078   -26.180 1.00 33.46 ? 67  ASP C O   1 
ATOM   5212 C  CB  . ASP C 1 62  ? -30.409 9.936   -23.346 1.00 32.27 ? 67  ASP C CB  1 
ATOM   5213 C  CG  . ASP C 1 62  ? -31.385 9.130   -22.515 1.00 32.79 ? 67  ASP C CG  1 
ATOM   5214 O  OD1 . ASP C 1 62  ? -31.559 7.904   -22.709 1.00 33.97 ? 67  ASP C OD1 1 
ATOM   5215 O  OD2 . ASP C 1 62  ? -32.011 9.752   -21.635 1.00 35.67 ? 67  ASP C OD2 1 
ATOM   5216 N  N   . PHE C 1 63  ? -29.947 7.103   -25.527 1.00 33.00 ? 68  PHE C N   1 
ATOM   5217 C  CA  . PHE C 1 63  ? -30.683 6.332   -26.548 1.00 33.32 ? 68  PHE C CA  1 
ATOM   5218 C  C   . PHE C 1 63  ? -32.142 6.086   -26.119 1.00 33.84 ? 68  PHE C C   1 
ATOM   5219 O  O   . PHE C 1 63  ? -32.937 5.513   -26.871 1.00 34.35 ? 68  PHE C O   1 
ATOM   5220 C  CB  . PHE C 1 63  ? -29.982 5.002   -26.837 1.00 33.24 ? 68  PHE C CB  1 
ATOM   5221 C  CG  . PHE C 1 63  ? -28.678 5.137   -27.572 1.00 32.43 ? 68  PHE C CG  1 
ATOM   5222 C  CD1 . PHE C 1 63  ? -27.562 5.687   -26.959 1.00 32.08 ? 68  PHE C CD1 1 
ATOM   5223 C  CD2 . PHE C 1 63  ? -28.561 4.680   -28.882 1.00 32.55 ? 68  PHE C CD2 1 
ATOM   5224 C  CE1 . PHE C 1 63  ? -26.348 5.813   -27.645 1.00 32.82 ? 68  PHE C CE1 1 
ATOM   5225 C  CE2 . PHE C 1 63  ? -27.342 4.778   -29.579 1.00 33.31 ? 68  PHE C CE2 1 
ATOM   5226 C  CZ  . PHE C 1 63  ? -26.234 5.353   -28.962 1.00 34.08 ? 68  PHE C CZ  1 
ATOM   5227 N  N   . GLY C 1 64  ? -32.498 6.523   -24.916 1.00 34.52 ? 69  GLY C N   1 
ATOM   5228 C  CA  . GLY C 1 64  ? -33.868 6.363   -24.426 1.00 35.67 ? 69  GLY C CA  1 
ATOM   5229 C  C   . GLY C 1 64  ? -34.107 4.962   -23.905 1.00 36.85 ? 69  GLY C C   1 
ATOM   5230 O  O   . GLY C 1 64  ? -33.154 4.198   -23.663 1.00 36.26 ? 69  GLY C O   1 
ATOM   5231 N  N   . ASP C 1 65  ? -35.375 4.623   -23.718 1.00 37.70 ? 70  ASP C N   1 
ATOM   5232 C  CA  . ASP C 1 65  ? -35.731 3.289   -23.256 1.00 39.18 ? 70  ASP C CA  1 
ATOM   5233 C  C   . ASP C 1 65  ? -36.266 2.483   -24.426 1.00 39.65 ? 70  ASP C C   1 
ATOM   5234 O  O   . ASP C 1 65  ? -37.245 2.873   -25.064 1.00 39.16 ? 70  ASP C O   1 
ATOM   5235 C  CB  . ASP C 1 65  ? -36.736 3.349   -22.105 1.00 39.27 ? 70  ASP C CB  1 
ATOM   5236 C  CG  . ASP C 1 65  ? -36.211 4.126   -20.912 1.00 40.40 ? 70  ASP C CG  1 
ATOM   5237 O  OD1 . ASP C 1 65  ? -34.977 4.285   -20.778 1.00 41.29 ? 70  ASP C OD1 1 
ATOM   5238 O  OD2 . ASP C 1 65  ? -37.039 4.582   -20.094 1.00 43.37 ? 70  ASP C OD2 1 
ATOM   5239 N  N   . LEU C 1 66  ? -35.603 1.365   -24.714 1.00 39.85 ? 71  LEU C N   1 
ATOM   5240 C  CA  . LEU C 1 66  ? -35.941 0.551   -25.877 1.00 40.61 ? 71  LEU C CA  1 
ATOM   5241 C  C   . LEU C 1 66  ? -37.303 -0.115  -25.741 1.00 41.53 ? 71  LEU C C   1 
ATOM   5242 O  O   . LEU C 1 66  ? -37.758 -0.429  -24.634 1.00 41.20 ? 71  LEU C O   1 
ATOM   5243 C  CB  . LEU C 1 66  ? -34.866 -0.503  -26.139 1.00 40.24 ? 71  LEU C CB  1 
ATOM   5244 C  CG  . LEU C 1 66  ? -33.406 -0.044  -26.235 1.00 39.88 ? 71  LEU C CG  1 
ATOM   5245 C  CD1 . LEU C 1 66  ? -32.528 -1.264  -26.245 1.00 39.45 ? 71  LEU C CD1 1 
ATOM   5246 C  CD2 . LEU C 1 66  ? -33.112 0.850   -27.457 1.00 40.46 ? 71  LEU C CD2 1 
ATOM   5247 N  N   . SER C 1 67  ? -37.957 -0.315  -26.880 1.00 42.83 ? 72  SER C N   1 
ATOM   5248 C  CA  . SER C 1 67  ? -39.225 -1.013  -26.918 1.00 43.89 ? 72  SER C CA  1 
ATOM   5249 C  C   . SER C 1 67  ? -38.974 -2.331  -27.631 1.00 45.06 ? 72  SER C C   1 
ATOM   5250 O  O   . SER C 1 67  ? -38.691 -2.352  -28.828 1.00 45.20 ? 72  SER C O   1 
ATOM   5251 C  CB  . SER C 1 67  ? -40.276 -0.176  -27.656 1.00 43.86 ? 72  SER C CB  1 
ATOM   5252 O  OG  . SER C 1 67  ? -41.582 -0.617  -27.313 1.00 44.33 ? 72  SER C OG  1 
ATOM   5253 N  N   . PHE C 1 68  ? -39.045 -3.431  -26.892 1.00 46.31 ? 73  PHE C N   1 
ATOM   5254 C  CA  . PHE C 1 68  ? -38.704 -4.722  -27.470 1.00 47.74 ? 73  PHE C CA  1 
ATOM   5255 C  C   . PHE C 1 68  ? -39.894 -5.346  -28.180 1.00 48.75 ? 73  PHE C C   1 
ATOM   5256 O  O   . PHE C 1 68  ? -41.016 -5.321  -27.667 1.00 48.97 ? 73  PHE C O   1 
ATOM   5257 C  CB  . PHE C 1 68  ? -38.116 -5.674  -26.417 1.00 47.63 ? 73  PHE C CB  1 
ATOM   5258 C  CG  . PHE C 1 68  ? -36.862 -5.156  -25.777 1.00 48.00 ? 73  PHE C CG  1 
ATOM   5259 C  CD1 . PHE C 1 68  ? -36.851 -4.802  -24.434 1.00 48.02 ? 73  PHE C CD1 1 
ATOM   5260 C  CD2 . PHE C 1 68  ? -35.699 -4.977  -26.533 1.00 48.56 ? 73  PHE C CD2 1 
ATOM   5261 C  CE1 . PHE C 1 68  ? -35.697 -4.304  -23.842 1.00 48.50 ? 73  PHE C CE1 1 
ATOM   5262 C  CE2 . PHE C 1 68  ? -34.542 -4.478  -25.953 1.00 48.99 ? 73  PHE C CE2 1 
ATOM   5263 C  CZ  . PHE C 1 68  ? -34.538 -4.142  -24.597 1.00 48.28 ? 73  PHE C CZ  1 
ATOM   5264 N  N   . THR C 1 69  ? -39.616 -5.898  -29.361 1.00 50.05 ? 74  THR C N   1 
ATOM   5265 C  CA  . THR C 1 69  ? -40.585 -6.606  -30.192 1.00 51.24 ? 74  THR C CA  1 
ATOM   5266 C  C   . THR C 1 69  ? -41.165 -7.791  -29.415 1.00 52.15 ? 74  THR C C   1 
ATOM   5267 O  O   . THR C 1 69  ? -40.426 -8.725  -29.072 1.00 52.23 ? 74  THR C O   1 
ATOM   5268 C  CB  . THR C 1 69  ? -39.910 -7.129  -31.490 1.00 51.46 ? 74  THR C CB  1 
ATOM   5269 O  OG1 . THR C 1 69  ? -39.180 -6.063  -32.110 1.00 51.58 ? 74  THR C OG1 1 
ATOM   5270 C  CG2 . THR C 1 69  ? -40.934 -7.703  -32.483 1.00 51.24 ? 74  THR C CG2 1 
ATOM   5271 N  N   . PRO C 1 70  ? -42.485 -7.755  -29.123 1.00 52.85 ? 75  PRO C N   1 
ATOM   5272 C  CA  . PRO C 1 70  ? -43.049 -8.900  -28.420 1.00 53.35 ? 75  PRO C CA  1 
ATOM   5273 C  C   . PRO C 1 70  ? -42.993 -10.175 -29.265 1.00 53.84 ? 75  PRO C C   1 
ATOM   5274 O  O   . PRO C 1 70  ? -42.764 -10.130 -30.484 1.00 53.59 ? 75  PRO C O   1 
ATOM   5275 C  CB  . PRO C 1 70  ? -44.500 -8.480  -28.152 1.00 53.34 ? 75  PRO C CB  1 
ATOM   5276 C  CG  . PRO C 1 70  ? -44.479 -6.987  -28.217 1.00 53.68 ? 75  PRO C CG  1 
ATOM   5277 C  CD  . PRO C 1 70  ? -43.476 -6.675  -29.290 1.00 52.87 ? 75  PRO C CD  1 
ATOM   5278 N  N   . VAL C 1 71  ? -43.143 -11.305 -28.584 1.00 54.49 ? 76  VAL C N   1 
ATOM   5279 C  CA  . VAL C 1 71  ? -43.305 -12.595 -29.225 1.00 55.05 ? 76  VAL C CA  1 
ATOM   5280 C  C   . VAL C 1 71  ? -44.643 -13.137 -28.698 1.00 55.59 ? 76  VAL C C   1 
ATOM   5281 O  O   . VAL C 1 71  ? -44.819 -13.273 -27.476 1.00 55.88 ? 76  VAL C O   1 
ATOM   5282 C  CB  . VAL C 1 71  ? -42.113 -13.546 -28.921 1.00 54.95 ? 76  VAL C CB  1 
ATOM   5283 C  CG1 . VAL C 1 71  ? -42.226 -14.842 -29.726 1.00 55.14 ? 76  VAL C CG1 1 
ATOM   5284 C  CG2 . VAL C 1 71  ? -40.786 -12.859 -29.227 1.00 54.48 ? 76  VAL C CG2 1 
ATOM   5285 N  N   . PRO C 1 72  ? -45.607 -13.401 -29.608 1.00 55.96 ? 77  PRO C N   1 
ATOM   5286 C  CA  . PRO C 1 72  ? -46.950 -13.827 -29.181 1.00 56.04 ? 77  PRO C CA  1 
ATOM   5287 C  C   . PRO C 1 72  ? -46.923 -15.183 -28.469 1.00 56.07 ? 77  PRO C C   1 
ATOM   5288 O  O   . PRO C 1 72  ? -47.268 -15.269 -27.281 1.00 56.15 ? 77  PRO C O   1 
ATOM   5289 C  CB  . PRO C 1 72  ? -47.731 -13.913 -30.501 1.00 56.12 ? 77  PRO C CB  1 
ATOM   5290 C  CG  . PRO C 1 72  ? -46.668 -14.152 -31.556 1.00 56.18 ? 77  PRO C CG  1 
ATOM   5291 C  CD  . PRO C 1 72  ? -45.489 -13.343 -31.081 1.00 56.13 ? 77  PRO C CD  1 
ATOM   5292 N  N   . LYS C 1 73  ? -46.493 -16.221 -29.191 1.00 55.91 ? 78  LYS C N   1 
ATOM   5293 C  CA  . LYS C 1 73  ? -46.424 -17.579 -28.658 1.00 55.33 ? 78  LYS C CA  1 
ATOM   5294 C  C   . LYS C 1 73  ? -44.991 -17.828 -28.226 1.00 54.78 ? 78  LYS C C   1 
ATOM   5295 O  O   . LYS C 1 73  ? -44.054 -17.579 -28.991 1.00 54.96 ? 78  LYS C O   1 
ATOM   5296 C  CB  . LYS C 1 73  ? -46.857 -18.607 -29.712 1.00 55.32 ? 78  LYS C CB  1 
ATOM   5297 C  CG  . LYS C 1 73  ? -48.262 -18.379 -30.281 1.00 55.60 ? 78  LYS C CG  1 
ATOM   5298 C  CD  . LYS C 1 73  ? -49.359 -18.776 -29.289 1.00 54.48 ? 78  LYS C CD  1 
ATOM   5299 C  CE  . LYS C 1 73  ? -50.694 -18.143 -29.649 1.00 53.34 ? 78  LYS C CE  1 
ATOM   5300 N  NZ  . LYS C 1 73  ? -51.808 -18.713 -28.821 1.00 52.76 ? 78  LYS C NZ  1 
ATOM   5301 N  N   . ASP C 1 74  ? -44.832 -18.318 -26.999 1.00 53.85 ? 79  ASP C N   1 
ATOM   5302 C  CA  . ASP C 1 74  ? -43.531 -18.366 -26.348 1.00 52.91 ? 79  ASP C CA  1 
ATOM   5303 C  C   . ASP C 1 74  ? -43.667 -19.025 -24.976 1.00 53.00 ? 79  ASP C C   1 
ATOM   5304 O  O   . ASP C 1 74  ? -43.342 -18.431 -23.944 1.00 53.15 ? 79  ASP C O   1 
ATOM   5305 C  CB  . ASP C 1 74  ? -42.979 -16.941 -26.207 1.00 52.38 ? 79  ASP C CB  1 
ATOM   5306 C  CG  . ASP C 1 74  ? -41.525 -16.910 -25.781 1.00 50.83 ? 79  ASP C CG  1 
ATOM   5307 O  OD1 . ASP C 1 74  ? -40.785 -17.890 -26.023 1.00 47.61 ? 79  ASP C OD1 1 
ATOM   5308 O  OD2 . ASP C 1 74  ? -41.135 -15.894 -25.188 1.00 48.62 ? 79  ASP C OD2 1 
ATOM   5309 N  N   . ASP C 1 75  ? -44.164 -20.253 -24.960 1.00 52.84 ? 80  ASP C N   1 
ATOM   5310 C  CA  . ASP C 1 75  ? -44.434 -20.924 -23.689 1.00 52.82 ? 80  ASP C CA  1 
ATOM   5311 C  C   . ASP C 1 75  ? -43.255 -21.770 -23.218 1.00 52.21 ? 80  ASP C C   1 
ATOM   5312 O  O   . ASP C 1 75  ? -42.223 -21.834 -23.896 1.00 52.48 ? 80  ASP C O   1 
ATOM   5313 C  CB  . ASP C 1 75  ? -45.747 -21.730 -23.739 1.00 53.22 ? 80  ASP C CB  1 
ATOM   5314 C  CG  . ASP C 1 75  ? -46.353 -21.797 -25.139 1.00 54.15 ? 80  ASP C CG  1 
ATOM   5315 O  OD1 . ASP C 1 75  ? -47.360 -21.097 -25.387 1.00 53.63 ? 80  ASP C OD1 1 
ATOM   5316 O  OD2 . ASP C 1 75  ? -45.812 -22.535 -25.995 1.00 56.82 ? 80  ASP C OD2 1 
ATOM   5317 N  N   . LEU C 1 76  ? -43.415 -22.381 -22.043 1.00 51.04 ? 81  LEU C N   1 
ATOM   5318 C  CA  . LEU C 1 76  ? -42.401 -23.253 -21.453 1.00 50.01 ? 81  LEU C CA  1 
ATOM   5319 C  C   . LEU C 1 76  ? -41.787 -24.185 -22.478 1.00 48.72 ? 81  LEU C C   1 
ATOM   5320 O  O   . LEU C 1 76  ? -42.495 -24.876 -23.217 1.00 48.99 ? 81  LEU C O   1 
ATOM   5321 C  CB  . LEU C 1 76  ? -42.982 -24.059 -20.289 1.00 50.37 ? 81  LEU C CB  1 
ATOM   5322 C  CG  . LEU C 1 76  ? -43.169 -23.307 -18.970 1.00 50.88 ? 81  LEU C CG  1 
ATOM   5323 C  CD1 . LEU C 1 76  ? -43.982 -24.143 -17.981 1.00 51.46 ? 81  LEU C CD1 1 
ATOM   5324 C  CD2 . LEU C 1 76  ? -41.820 -22.903 -18.367 1.00 51.51 ? 81  LEU C CD2 1 
ATOM   5325 N  N   . TYR C 1 77  ? -40.464 -24.167 -22.537 1.00 46.95 ? 82  TYR C N   1 
ATOM   5326 C  CA  . TYR C 1 77  ? -39.726 -24.987 -23.471 1.00 45.36 ? 82  TYR C CA  1 
ATOM   5327 C  C   . TYR C 1 77  ? -39.191 -26.189 -22.703 1.00 44.51 ? 82  TYR C C   1 
ATOM   5328 O  O   . TYR C 1 77  ? -38.424 -26.032 -21.747 1.00 43.53 ? 82  TYR C O   1 
ATOM   5329 C  CB  . TYR C 1 77  ? -38.605 -24.175 -24.107 1.00 45.22 ? 82  TYR C CB  1 
ATOM   5330 C  CG  . TYR C 1 77  ? -37.871 -24.883 -25.222 1.00 44.79 ? 82  TYR C CG  1 
ATOM   5331 C  CD1 . TYR C 1 77  ? -38.486 -25.110 -26.457 1.00 43.74 ? 82  TYR C CD1 1 
ATOM   5332 C  CD2 . TYR C 1 77  ? -36.554 -25.318 -25.048 1.00 43.76 ? 82  TYR C CD2 1 
ATOM   5333 C  CE1 . TYR C 1 77  ? -37.803 -25.760 -27.492 1.00 43.36 ? 82  TYR C CE1 1 
ATOM   5334 C  CE2 . TYR C 1 77  ? -35.869 -25.967 -26.075 1.00 43.85 ? 82  TYR C CE2 1 
ATOM   5335 C  CZ  . TYR C 1 77  ? -36.505 -26.183 -27.290 1.00 42.67 ? 82  TYR C CZ  1 
ATOM   5336 O  OH  . TYR C 1 77  ? -35.841 -26.815 -28.301 1.00 42.96 ? 82  TYR C OH  1 
ATOM   5337 N  N   . ASN C 1 78  ? -39.627 -27.378 -23.117 1.00 43.34 ? 83  ASN C N   1 
ATOM   5338 C  CA  . ASN C 1 78  ? -39.341 -28.637 -22.410 1.00 42.98 ? 83  ASN C CA  1 
ATOM   5339 C  C   . ASN C 1 78  ? -39.773 -28.611 -20.942 1.00 42.16 ? 83  ASN C C   1 
ATOM   5340 O  O   . ASN C 1 78  ? -39.062 -29.096 -20.060 1.00 41.95 ? 83  ASN C O   1 
ATOM   5341 C  CB  . ASN C 1 78  ? -37.869 -29.043 -22.566 1.00 42.64 ? 83  ASN C CB  1 
ATOM   5342 C  CG  . ASN C 1 78  ? -37.521 -29.414 -23.990 1.00 43.30 ? 83  ASN C CG  1 
ATOM   5343 O  OD1 . ASN C 1 78  ? -38.296 -30.092 -24.670 1.00 42.87 ? 83  ASN C OD1 1 
ATOM   5344 N  ND2 . ASN C 1 78  ? -36.352 -28.975 -24.455 1.00 40.05 ? 83  ASN C ND2 1 
ATOM   5345 N  N   . ASN C 1 79  ? -40.945 -28.025 -20.712 1.00 41.86 ? 84  ASN C N   1 
ATOM   5346 C  CA  . ASN C 1 79  ? -41.518 -27.787 -19.377 1.00 42.39 ? 84  ASN C CA  1 
ATOM   5347 C  C   . ASN C 1 79  ? -40.596 -27.065 -18.374 1.00 41.52 ? 84  ASN C C   1 
ATOM   5348 O  O   . ASN C 1 79  ? -40.842 -27.093 -17.167 1.00 41.70 ? 84  ASN C O   1 
ATOM   5349 C  CB  . ASN C 1 79  ? -42.089 -29.087 -18.762 1.00 42.78 ? 84  ASN C CB  1 
ATOM   5350 C  CG  . ASN C 1 79  ? -43.520 -29.361 -19.190 1.00 44.75 ? 84  ASN C CG  1 
ATOM   5351 O  OD1 . ASN C 1 79  ? -44.195 -28.512 -19.805 1.00 44.73 ? 84  ASN C OD1 1 
ATOM   5352 N  ND2 . ASN C 1 79  ? -43.998 -30.560 -18.873 1.00 46.78 ? 84  ASN C ND2 1 
ATOM   5353 N  N   . LEU C 1 80  ? -39.569 -26.386 -18.881 1.00 40.41 ? 85  LEU C N   1 
ATOM   5354 C  CA  . LEU C 1 80  ? -38.556 -25.787 -18.014 1.00 39.19 ? 85  LEU C CA  1 
ATOM   5355 C  C   . LEU C 1 80  ? -38.210 -24.341 -18.379 1.00 37.94 ? 85  LEU C C   1 
ATOM   5356 O  O   . LEU C 1 80  ? -38.383 -23.454 -17.555 1.00 37.10 ? 85  LEU C O   1 
ATOM   5357 C  CB  . LEU C 1 80  ? -37.299 -26.665 -17.964 1.00 39.22 ? 85  LEU C CB  1 
ATOM   5358 C  CG  . LEU C 1 80  ? -36.083 -26.225 -17.130 1.00 39.30 ? 85  LEU C CG  1 
ATOM   5359 C  CD1 . LEU C 1 80  ? -36.397 -26.176 -15.631 1.00 39.94 ? 85  LEU C CD1 1 
ATOM   5360 C  CD2 . LEU C 1 80  ? -34.893 -27.135 -17.407 1.00 39.09 ? 85  LEU C CD2 1 
ATOM   5361 N  N   . ILE C 1 81  ? -37.727 -24.101 -19.598 1.00 36.91 ? 86  ILE C N   1 
ATOM   5362 C  CA  . ILE C 1 81  ? -37.236 -22.758 -19.957 1.00 36.37 ? 86  ILE C CA  1 
ATOM   5363 C  C   . ILE C 1 81  ? -38.390 -21.786 -20.201 1.00 36.38 ? 86  ILE C C   1 
ATOM   5364 O  O   . ILE C 1 81  ? -39.244 -22.015 -21.055 1.00 36.06 ? 86  ILE C O   1 
ATOM   5365 C  CB  . ILE C 1 81  ? -36.268 -22.774 -21.170 1.00 36.49 ? 86  ILE C CB  1 
ATOM   5366 C  CG1 . ILE C 1 81  ? -35.202 -23.875 -21.024 1.00 36.41 ? 86  ILE C CG1 1 
ATOM   5367 C  CG2 . ILE C 1 81  ? -35.635 -21.399 -21.377 1.00 35.16 ? 86  ILE C CG2 1 
ATOM   5368 C  CD1 . ILE C 1 81  ? -34.297 -23.772 -19.779 1.00 37.27 ? 86  ILE C CD1 1 
ATOM   5369 N  N   . VAL C 1 82  ? -38.414 -20.709 -19.434 1.00 35.98 ? 87  VAL C N   1 
ATOM   5370 C  CA  . VAL C 1 82  ? -39.461 -19.708 -19.568 1.00 36.76 ? 87  VAL C CA  1 
ATOM   5371 C  C   . VAL C 1 82  ? -39.095 -18.626 -20.598 1.00 36.36 ? 87  VAL C C   1 
ATOM   5372 O  O   . VAL C 1 82  ? -37.995 -18.050 -20.575 1.00 35.43 ? 87  VAL C O   1 
ATOM   5373 C  CB  . VAL C 1 82  ? -39.903 -19.126 -18.180 1.00 37.03 ? 87  VAL C CB  1 
ATOM   5374 C  CG1 . VAL C 1 82  ? -38.759 -18.471 -17.479 1.00 38.59 ? 87  VAL C CG1 1 
ATOM   5375 C  CG2 . VAL C 1 82  ? -41.059 -18.154 -18.324 1.00 37.46 ? 87  VAL C CG2 1 
ATOM   5376 N  N   . ASN C 1 83  ? -40.034 -18.404 -21.517 1.00 36.58 ? 88  ASN C N   1 
ATOM   5377 C  CA  . ASN C 1 83  ? -39.957 -17.376 -22.573 1.00 37.22 ? 88  ASN C CA  1 
ATOM   5378 C  C   . ASN C 1 83  ? -38.656 -17.281 -23.388 1.00 36.46 ? 88  ASN C C   1 
ATOM   5379 O  O   . ASN C 1 83  ? -38.143 -16.163 -23.572 1.00 36.54 ? 88  ASN C O   1 
ATOM   5380 C  CB  . ASN C 1 83  ? -40.268 -15.989 -21.997 1.00 37.67 ? 88  ASN C CB  1 
ATOM   5381 C  CG  . ASN C 1 83  ? -41.523 -15.968 -21.143 1.00 40.59 ? 88  ASN C CG  1 
ATOM   5382 O  OD1 . ASN C 1 83  ? -42.550 -16.537 -21.511 1.00 43.36 ? 88  ASN C OD1 1 
ATOM   5383 N  ND2 . ASN C 1 83  ? -41.443 -15.295 -19.997 1.00 41.90 ? 88  ASN C ND2 1 
ATOM   5384 N  N   . PRO C 1 84  ? -38.126 -18.415 -23.902 1.00 35.72 ? 89  PRO C N   1 
ATOM   5385 C  CA  . PRO C 1 84  ? -36.830 -18.266 -24.594 1.00 35.46 ? 89  PRO C CA  1 
ATOM   5386 C  C   . PRO C 1 84  ? -36.851 -17.368 -25.843 1.00 35.15 ? 89  PRO C C   1 
ATOM   5387 O  O   . PRO C 1 84  ? -35.915 -16.591 -26.058 1.00 34.75 ? 89  PRO C O   1 
ATOM   5388 C  CB  . PRO C 1 84  ? -36.447 -19.706 -24.954 1.00 35.23 ? 89  PRO C CB  1 
ATOM   5389 C  CG  . PRO C 1 84  ? -37.753 -20.451 -24.980 1.00 35.63 ? 89  PRO C CG  1 
ATOM   5390 C  CD  . PRO C 1 84  ? -38.588 -19.821 -23.916 1.00 35.53 ? 89  PRO C CD  1 
ATOM   5391 N  N   . ARG C 1 85  ? -37.899 -17.463 -26.658 1.00 35.15 ? 90  ARG C N   1 
ATOM   5392 C  CA  . ARG C 1 85  ? -37.987 -16.608 -27.856 1.00 34.78 ? 90  ARG C CA  1 
ATOM   5393 C  C   . ARG C 1 85  ? -37.947 -15.115 -27.522 1.00 33.94 ? 90  ARG C C   1 
ATOM   5394 O  O   . ARG C 1 85  ? -37.196 -14.371 -28.153 1.00 33.31 ? 90  ARG C O   1 
ATOM   5395 C  CB  . ARG C 1 85  ? -39.227 -16.943 -28.694 1.00 35.57 ? 90  ARG C CB  1 
ATOM   5396 C  CG  . ARG C 1 85  ? -39.225 -18.365 -29.203 1.00 38.81 ? 90  ARG C CG  1 
ATOM   5397 C  CD  . ARG C 1 85  ? -40.605 -18.819 -29.701 1.00 43.94 ? 90  ARG C CD  1 
ATOM   5398 N  NE  . ARG C 1 85  ? -40.519 -20.133 -30.344 1.00 47.65 ? 90  ARG C NE  1 
ATOM   5399 C  CZ  . ARG C 1 85  ? -40.799 -21.296 -29.751 1.00 50.54 ? 90  ARG C CZ  1 
ATOM   5400 N  NH1 . ARG C 1 85  ? -41.204 -21.331 -28.485 1.00 51.16 ? 90  ARG C NH1 1 
ATOM   5401 N  NH2 . ARG C 1 85  ? -40.682 -22.441 -30.429 1.00 52.22 ? 90  ARG C NH2 1 
ATOM   5402 N  N   . SER C 1 86  ? -38.743 -14.678 -26.539 1.00 33.18 ? 91  SER C N   1 
ATOM   5403 C  CA  . SER C 1 86  ? -38.759 -13.266 -26.150 1.00 32.24 ? 91  SER C CA  1 
ATOM   5404 C  C   . SER C 1 86  ? -37.407 -12.852 -25.584 1.00 30.85 ? 91  SER C C   1 
ATOM   5405 O  O   . SER C 1 86  ? -36.892 -11.784 -25.915 1.00 29.07 ? 91  SER C O   1 
ATOM   5406 C  CB  . SER C 1 86  ? -39.849 -12.950 -25.126 1.00 32.96 ? 91  SER C CB  1 
ATOM   5407 O  OG  . SER C 1 86  ? -41.083 -13.555 -25.475 1.00 35.73 ? 91  SER C OG  1 
ATOM   5408 N  N   . VAL C 1 87  ? -36.845 -13.692 -24.720 1.00 29.30 ? 92  VAL C N   1 
ATOM   5409 C  CA  . VAL C 1 87  ? -35.531 -13.377 -24.155 1.00 28.72 ? 92  VAL C CA  1 
ATOM   5410 C  C   . VAL C 1 87  ? -34.484 -13.317 -25.256 1.00 28.25 ? 92  VAL C C   1 
ATOM   5411 O  O   . VAL C 1 87  ? -33.667 -12.399 -25.275 1.00 28.05 ? 92  VAL C O   1 
ATOM   5412 C  CB  . VAL C 1 87  ? -35.132 -14.328 -23.008 1.00 28.63 ? 92  VAL C CB  1 
ATOM   5413 C  CG1 . VAL C 1 87  ? -33.670 -14.068 -22.579 1.00 26.90 ? 92  VAL C CG1 1 
ATOM   5414 C  CG2 . VAL C 1 87  ? -36.104 -14.133 -21.844 1.00 27.83 ? 92  VAL C CG2 1 
ATOM   5415 N  N   . GLY C 1 88  ? -34.537 -14.277 -26.178 1.00 27.95 ? 93  GLY C N   1 
ATOM   5416 C  CA  . GLY C 1 88  ? -33.542 -14.365 -27.247 1.00 28.50 ? 93  GLY C CA  1 
ATOM   5417 C  C   . GLY C 1 88  ? -33.585 -13.150 -28.160 1.00 28.27 ? 93  GLY C C   1 
ATOM   5418 O  O   . GLY C 1 88  ? -32.555 -12.579 -28.488 1.00 27.81 ? 93  GLY C O   1 
ATOM   5419 N  N   . LEU C 1 89  ? -34.796 -12.737 -28.529 1.00 28.68 ? 94  LEU C N   1 
ATOM   5420 C  CA  . LEU C 1 89  ? -34.983 -11.639 -29.486 1.00 29.24 ? 94  LEU C CA  1 
ATOM   5421 C  C   . LEU C 1 89  ? -34.709 -10.271 -28.885 1.00 28.52 ? 94  LEU C C   1 
ATOM   5422 O  O   . LEU C 1 89  ? -34.072 -9.424  -29.524 1.00 28.99 ? 94  LEU C O   1 
ATOM   5423 C  CB  . LEU C 1 89  ? -36.392 -11.698 -30.116 1.00 29.81 ? 94  LEU C CB  1 
ATOM   5424 C  CG  . LEU C 1 89  ? -36.685 -10.706 -31.272 1.00 31.56 ? 94  LEU C CG  1 
ATOM   5425 C  CD1 . LEU C 1 89  ? -35.651 -10.761 -32.424 1.00 32.28 ? 94  LEU C CD1 1 
ATOM   5426 C  CD2 . LEU C 1 89  ? -38.119 -10.920 -31.818 1.00 32.81 ? 94  LEU C CD2 1 
ATOM   5427 N  N   . ALA C 1 90  ? -35.197 -10.052 -27.662 1.00 27.86 ? 95  ALA C N   1 
ATOM   5428 C  CA  . ALA C 1 90  ? -34.933 -8.820  -26.931 1.00 27.10 ? 95  ALA C CA  1 
ATOM   5429 C  C   . ALA C 1 90  ? -33.433 -8.593  -26.792 1.00 26.74 ? 95  ALA C C   1 
ATOM   5430 O  O   . ALA C 1 90  ? -32.933 -7.488  -27.008 1.00 25.17 ? 95  ALA C O   1 
ATOM   5431 C  CB  . ALA C 1 90  ? -35.603 -8.840  -25.545 1.00 27.50 ? 95  ALA C CB  1 
ATOM   5432 N  N   . ASN C 1 91  ? -32.710 -9.653  -26.455 1.00 27.11 ? 96  ASN C N   1 
ATOM   5433 C  CA  . ASN C 1 91  ? -31.257 -9.540  -26.373 1.00 26.51 ? 96  ASN C CA  1 
ATOM   5434 C  C   . ASN C 1 91  ? -30.567 -9.307  -27.715 1.00 27.27 ? 96  ASN C C   1 
ATOM   5435 O  O   . ASN C 1 91  ? -29.559 -8.586  -27.778 1.00 25.70 ? 96  ASN C O   1 
ATOM   5436 C  CB  . ASN C 1 91  ? -30.671 -10.747 -25.676 1.00 26.74 ? 96  ASN C CB  1 
ATOM   5437 C  CG  . ASN C 1 91  ? -30.719 -10.597 -24.199 1.00 26.23 ? 96  ASN C CG  1 
ATOM   5438 O  OD1 . ASN C 1 91  ? -30.068 -9.716  -23.652 1.00 25.46 ? 96  ASN C OD1 1 
ATOM   5439 N  ND2 . ASN C 1 91  ? -31.508 -11.434 -23.533 1.00 28.01 ? 96  ASN C ND2 1 
ATOM   5440 N  N   . GLN C 1 92  ? -31.100 -9.912  -28.780 1.00 27.16 ? 97  GLN C N   1 
ATOM   5441 C  CA  . GLN C 1 92  ? -30.519 -9.691  -30.098 1.00 27.50 ? 97  GLN C CA  1 
ATOM   5442 C  C   . GLN C 1 92  ? -30.642 -8.217  -30.472 1.00 27.09 ? 97  GLN C C   1 
ATOM   5443 O  O   . GLN C 1 92  ? -29.715 -7.628  -31.020 1.00 26.75 ? 97  GLN C O   1 
ATOM   5444 C  CB  . GLN C 1 92  ? -31.136 -10.596 -31.166 1.00 28.13 ? 97  GLN C CB  1 
ATOM   5445 C  CG  . GLN C 1 92  ? -30.360 -10.499 -32.493 1.00 29.75 ? 97  GLN C CG  1 
ATOM   5446 C  CD  . GLN C 1 92  ? -30.930 -11.342 -33.609 1.00 32.29 ? 97  GLN C CD  1 
ATOM   5447 O  OE1 . GLN C 1 92  ? -32.102 -11.705 -33.592 1.00 33.54 ? 97  GLN C OE1 1 
ATOM   5448 N  NE2 . GLN C 1 92  ? -30.090 -11.666 -34.587 1.00 29.92 ? 97  GLN C NE2 1 
ATOM   5449 N  N   . GLU C 1 93  ? -31.768 -7.622  -30.113 1.00 27.62 ? 98  GLU C N   1 
ATOM   5450 C  CA  . GLU C 1 93  ? -32.061 -6.210  -30.368 1.00 28.30 ? 98  GLU C CA  1 
ATOM   5451 C  C   . GLU C 1 93  ? -31.193 -5.265  -29.534 1.00 28.12 ? 98  GLU C C   1 
ATOM   5452 O  O   . GLU C 1 93  ? -30.626 -4.279  -30.040 1.00 27.63 ? 98  GLU C O   1 
ATOM   5453 C  CB  . GLU C 1 93  ? -33.547 -5.957  -30.092 1.00 29.22 ? 98  GLU C CB  1 
ATOM   5454 C  CG  . GLU C 1 93  ? -34.450 -6.667  -31.107 1.00 32.19 ? 98  GLU C CG  1 
ATOM   5455 C  CD  . GLU C 1 93  ? -35.939 -6.367  -30.959 1.00 37.32 ? 98  GLU C CD  1 
ATOM   5456 O  OE1 . GLU C 1 93  ? -36.419 -5.992  -29.868 1.00 36.88 ? 98  GLU C OE1 1 
ATOM   5457 O  OE2 . GLU C 1 93  ? -36.655 -6.535  -31.972 1.00 42.00 ? 98  GLU C OE2 1 
ATOM   5458 N  N   . LEU C 1 94  ? -31.080 -5.580  -28.249 1.00 27.26 ? 99  LEU C N   1 
ATOM   5459 C  CA  . LEU C 1 94  ? -30.247 -4.806  -27.353 1.00 26.21 ? 99  LEU C CA  1 
ATOM   5460 C  C   . LEU C 1 94  ? -28.793 -4.868  -27.810 1.00 25.80 ? 99  LEU C C   1 
ATOM   5461 O  O   . LEU C 1 94  ? -28.109 -3.849  -27.825 1.00 25.87 ? 99  LEU C O   1 
ATOM   5462 C  CB  . LEU C 1 94  ? -30.423 -5.293  -25.913 1.00 26.09 ? 99  LEU C CB  1 
ATOM   5463 C  CG  . LEU C 1 94  ? -29.469 -4.697  -24.862 1.00 25.34 ? 99  LEU C CG  1 
ATOM   5464 C  CD1 . LEU C 1 94  ? -29.617 -3.192  -24.762 1.00 23.78 ? 99  LEU C CD1 1 
ATOM   5465 C  CD2 . LEU C 1 94  ? -29.763 -5.369  -23.518 1.00 23.13 ? 99  LEU C CD2 1 
ATOM   5466 N  N   . ALA C 1 95  ? -28.329 -6.049  -28.219 1.00 25.84 ? 100 ALA C N   1 
ATOM   5467 C  CA  . ALA C 1 95  ? -26.954 -6.201  -28.713 1.00 26.01 ? 100 ALA C CA  1 
ATOM   5468 C  C   . ALA C 1 95  ? -26.612 -5.235  -29.855 1.00 26.93 ? 100 ALA C C   1 
ATOM   5469 O  O   . ALA C 1 95  ? -25.472 -4.813  -30.000 1.00 26.55 ? 100 ALA C O   1 
ATOM   5470 C  CB  . ALA C 1 95  ? -26.701 -7.645  -29.148 1.00 26.41 ? 100 ALA C CB  1 
ATOM   5471 N  N   . GLU C 1 96  ? -27.611 -4.908  -30.679 1.00 27.61 ? 101 GLU C N   1 
ATOM   5472 C  CA  . GLU C 1 96  ? -27.379 -4.030  -31.812 1.00 28.34 ? 101 GLU C CA  1 
ATOM   5473 C  C   . GLU C 1 96  ? -27.143 -2.605  -31.309 1.00 27.38 ? 101 GLU C C   1 
ATOM   5474 O  O   . GLU C 1 96  ? -26.234 -1.912  -31.761 1.00 27.23 ? 101 GLU C O   1 
ATOM   5475 C  CB  . GLU C 1 96  ? -28.564 -4.087  -32.795 1.00 29.60 ? 101 GLU C CB  1 
ATOM   5476 C  CG  . GLU C 1 96  ? -28.127 -3.909  -34.241 1.00 33.64 ? 101 GLU C CG  1 
ATOM   5477 C  CD  . GLU C 1 96  ? -27.079 -4.930  -34.622 1.00 39.00 ? 101 GLU C CD  1 
ATOM   5478 O  OE1 . GLU C 1 96  ? -27.391 -6.143  -34.568 1.00 41.71 ? 101 GLU C OE1 1 
ATOM   5479 O  OE2 . GLU C 1 96  ? -25.934 -4.527  -34.936 1.00 40.73 ? 101 GLU C OE2 1 
ATOM   5480 N  N   . VAL C 1 97  ? -27.938 -2.189  -30.335 1.00 26.51 ? 102 VAL C N   1 
ATOM   5481 C  CA  . VAL C 1 97  ? -27.839 -0.817  -29.828 1.00 26.08 ? 102 VAL C CA  1 
ATOM   5482 C  C   . VAL C 1 97  ? -26.545 -0.609  -29.032 1.00 25.00 ? 102 VAL C C   1 
ATOM   5483 O  O   . VAL C 1 97  ? -25.884 0.414   -29.157 1.00 24.89 ? 102 VAL C O   1 
ATOM   5484 C  CB  . VAL C 1 97  ? -29.057 -0.427  -28.979 1.00 26.51 ? 102 VAL C CB  1 
ATOM   5485 C  CG1 . VAL C 1 97  ? -28.966 1.026   -28.525 1.00 26.77 ? 102 VAL C CG1 1 
ATOM   5486 C  CG2 . VAL C 1 97  ? -30.367 -0.682  -29.758 1.00 28.05 ? 102 VAL C CG2 1 
ATOM   5487 N  N   . VAL C 1 98  ? -26.210 -1.571  -28.183 1.00 23.57 ? 103 VAL C N   1 
ATOM   5488 C  CA  . VAL C 1 98  ? -24.955 -1.513  -27.428 1.00 23.63 ? 103 VAL C CA  1 
ATOM   5489 C  C   . VAL C 1 98  ? -23.783 -1.484  -28.412 1.00 23.33 ? 103 VAL C C   1 
ATOM   5490 O  O   . VAL C 1 98  ? -22.823 -0.722  -28.245 1.00 22.69 ? 103 VAL C O   1 
ATOM   5491 C  CB  . VAL C 1 98  ? -24.811 -2.743  -26.484 1.00 23.16 ? 103 VAL C CB  1 
ATOM   5492 C  CG1 . VAL C 1 98  ? -23.441 -2.754  -25.827 1.00 23.11 ? 103 VAL C CG1 1 
ATOM   5493 C  CG2 . VAL C 1 98  ? -25.968 -2.787  -25.462 1.00 22.58 ? 103 VAL C CG2 1 
ATOM   5494 N  N   . SER C 1 99  ? -23.875 -2.301  -29.454 1.00 23.96 ? 104 SER C N   1 
ATOM   5495 C  CA  . SER C 1 99  ? -22.849 -2.276  -30.497 1.00 25.20 ? 104 SER C CA  1 
ATOM   5496 C  C   . SER C 1 99  ? -22.701 -0.886  -31.121 1.00 25.94 ? 104 SER C C   1 
ATOM   5497 O  O   . SER C 1 99  ? -21.597 -0.370  -31.302 1.00 24.70 ? 104 SER C O   1 
ATOM   5498 C  CB  . SER C 1 99  ? -23.176 -3.297  -31.577 1.00 25.97 ? 104 SER C CB  1 
ATOM   5499 O  OG  . SER C 1 99  ? -22.282 -3.174  -32.647 1.00 26.09 ? 104 SER C OG  1 
ATOM   5500 N  N   . ARG C 1 100 ? -23.830 -0.290  -31.458 1.00 27.21 ? 105 ARG C N   1 
ATOM   5501 C  CA  . ARG C 1 100 ? -23.837 1.060   -32.015 1.00 28.74 ? 105 ARG C CA  1 
ATOM   5502 C  C   . ARG C 1 100 ? -23.143 2.057   -31.070 1.00 28.19 ? 105 ARG C C   1 
ATOM   5503 O  O   . ARG C 1 100 ? -22.249 2.812   -31.490 1.00 28.30 ? 105 ARG C O   1 
ATOM   5504 C  CB  . ARG C 1 100 ? -25.292 1.479   -32.333 1.00 29.39 ? 105 ARG C CB  1 
ATOM   5505 C  CG  . ARG C 1 100 ? -25.405 2.571   -33.396 1.00 34.60 ? 105 ARG C CG  1 
ATOM   5506 C  CD  . ARG C 1 100 ? -25.306 1.974   -34.823 1.00 42.04 ? 105 ARG C CD  1 
ATOM   5507 N  NE  . ARG C 1 100 ? -26.632 1.700   -35.401 1.00 46.09 ? 105 ARG C NE  1 
ATOM   5508 C  CZ  . ARG C 1 100 ? -27.329 0.571   -35.241 1.00 47.54 ? 105 ARG C CZ  1 
ATOM   5509 N  NH1 . ARG C 1 100 ? -26.841 -0.438  -34.520 1.00 48.90 ? 105 ARG C NH1 1 
ATOM   5510 N  NH2 . ARG C 1 100 ? -28.527 0.451   -35.805 1.00 48.41 ? 105 ARG C NH2 1 
ATOM   5511 N  N   . ALA C 1 101 ? -23.524 2.029   -29.792 1.00 27.28 ? 106 ALA C N   1 
ATOM   5512 C  CA  . ALA C 1 101 ? -23.001 2.978   -28.806 1.00 27.03 ? 106 ALA C CA  1 
ATOM   5513 C  C   . ALA C 1 101 ? -21.494 2.862   -28.633 1.00 27.06 ? 106 ALA C C   1 
ATOM   5514 O  O   . ALA C 1 101 ? -20.796 3.858   -28.600 1.00 26.49 ? 106 ALA C O   1 
ATOM   5515 C  CB  . ALA C 1 101 ? -23.712 2.791   -27.441 1.00 27.12 ? 106 ALA C CB  1 
ATOM   5516 N  N   . VAL C 1 102 ? -21.012 1.626   -28.526 1.00 26.63 ? 107 VAL C N   1 
ATOM   5517 C  CA  . VAL C 1 102 ? -19.594 1.356   -28.322 1.00 26.90 ? 107 VAL C CA  1 
ATOM   5518 C  C   . VAL C 1 102 ? -18.844 1.698   -29.607 1.00 27.73 ? 107 VAL C C   1 
ATOM   5519 O  O   . VAL C 1 102 ? -17.733 2.229   -29.574 1.00 26.74 ? 107 VAL C O   1 
ATOM   5520 C  CB  . VAL C 1 102 ? -19.360 -0.122  -27.947 1.00 26.30 ? 107 VAL C CB  1 
ATOM   5521 C  CG1 . VAL C 1 102 ? -17.862 -0.445  -27.862 1.00 24.63 ? 107 VAL C CG1 1 
ATOM   5522 C  CG2 . VAL C 1 102 ? -20.085 -0.446  -26.631 1.00 25.37 ? 107 VAL C CG2 1 
ATOM   5523 N  N   . SER C 1 103 ? -19.490 1.384   -30.727 1.00 28.99 ? 108 SER C N   1 
ATOM   5524 C  CA  . SER C 1 103 ? -18.997 1.714   -32.063 1.00 31.30 ? 108 SER C CA  1 
ATOM   5525 C  C   . SER C 1 103 ? -18.775 3.214   -32.213 1.00 31.25 ? 108 SER C C   1 
ATOM   5526 O  O   . SER C 1 103 ? -17.765 3.634   -32.789 1.00 31.17 ? 108 SER C O   1 
ATOM   5527 C  CB  . SER C 1 103 ? -19.996 1.233   -33.130 1.00 30.72 ? 108 SER C CB  1 
ATOM   5528 O  OG  . SER C 1 103 ? -19.355 1.126   -34.377 1.00 36.18 ? 108 SER C OG  1 
ATOM   5529 N  N   . ASP C 1 104 ? -19.743 3.998   -31.730 1.00 31.89 ? 109 ASP C N   1 
ATOM   5530 C  CA  . ASP C 1 104 ? -19.649 5.468   -31.694 1.00 32.27 ? 109 ASP C CA  1 
ATOM   5531 C  C   . ASP C 1 104 ? -18.707 6.029   -30.610 1.00 31.63 ? 109 ASP C C   1 
ATOM   5532 O  O   . ASP C 1 104 ? -18.556 7.241   -30.483 1.00 31.40 ? 109 ASP C O   1 
ATOM   5533 C  CB  . ASP C 1 104 ? -21.041 6.084   -31.517 1.00 33.35 ? 109 ASP C CB  1 
ATOM   5534 C  CG  . ASP C 1 104 ? -21.931 5.892   -32.731 1.00 35.93 ? 109 ASP C CG  1 
ATOM   5535 O  OD1 . ASP C 1 104 ? -21.422 5.993   -33.870 1.00 39.63 ? 109 ASP C OD1 1 
ATOM   5536 O  OD2 . ASP C 1 104 ? -23.141 5.633   -32.542 1.00 39.26 ? 109 ASP C OD2 1 
ATOM   5537 N  N   . GLY C 1 105 ? -18.087 5.153   -29.819 1.00 31.00 ? 110 GLY C N   1 
ATOM   5538 C  CA  . GLY C 1 105 ? -17.104 5.561   -28.816 1.00 29.23 ? 110 GLY C CA  1 
ATOM   5539 C  C   . GLY C 1 105 ? -17.615 5.913   -27.420 1.00 28.23 ? 110 GLY C C   1 
ATOM   5540 O  O   . GLY C 1 105 ? -16.899 6.548   -26.651 1.00 28.45 ? 110 GLY C O   1 
ATOM   5541 N  N   . TYR C 1 106 ? -18.835 5.502   -27.072 1.00 26.95 ? 111 TYR C N   1 
ATOM   5542 C  CA  . TYR C 1 106 ? -19.369 5.752   -25.718 1.00 25.91 ? 111 TYR C CA  1 
ATOM   5543 C  C   . TYR C 1 106 ? -19.114 4.578   -24.782 1.00 25.33 ? 111 TYR C C   1 
ATOM   5544 O  O   . TYR C 1 106 ? -19.185 3.418   -25.193 1.00 23.97 ? 111 TYR C O   1 
ATOM   5545 C  CB  . TYR C 1 106 ? -20.888 5.964   -25.755 1.00 25.86 ? 111 TYR C CB  1 
ATOM   5546 C  CG  . TYR C 1 106 ? -21.293 7.234   -26.468 1.00 29.11 ? 111 TYR C CG  1 
ATOM   5547 C  CD1 . TYR C 1 106 ? -21.571 7.226   -27.846 1.00 30.68 ? 111 TYR C CD1 1 
ATOM   5548 C  CD2 . TYR C 1 106 ? -21.364 8.446   -25.780 1.00 30.87 ? 111 TYR C CD2 1 
ATOM   5549 C  CE1 . TYR C 1 106 ? -21.931 8.395   -28.516 1.00 32.67 ? 111 TYR C CE1 1 
ATOM   5550 C  CE2 . TYR C 1 106 ? -21.725 9.624   -26.441 1.00 33.08 ? 111 TYR C CE2 1 
ATOM   5551 C  CZ  . TYR C 1 106 ? -22.004 9.587   -27.808 1.00 32.77 ? 111 TYR C CZ  1 
ATOM   5552 O  OH  . TYR C 1 106 ? -22.367 10.742  -28.451 1.00 34.71 ? 111 TYR C OH  1 
ATOM   5553 N  N   . SER C 1 107 ? -18.886 4.896   -23.507 1.00 25.41 ? 112 SER C N   1 
ATOM   5554 C  CA  . SER C 1 107 ? -19.040 3.911   -22.442 1.00 24.80 ? 112 SER C CA  1 
ATOM   5555 C  C   . SER C 1 107 ? -20.546 3.655   -22.322 1.00 23.95 ? 112 SER C C   1 
ATOM   5556 O  O   . SER C 1 107 ? -21.329 4.579   -22.128 1.00 23.42 ? 112 SER C O   1 
ATOM   5557 C  CB  . SER C 1 107 ? -18.466 4.455   -21.144 1.00 25.12 ? 112 SER C CB  1 
ATOM   5558 O  OG  . SER C 1 107 ? -17.126 4.842   -21.345 1.00 26.58 ? 112 SER C OG  1 
ATOM   5559 N  N   . CYS C 1 108 ? -20.952 2.409   -22.472 1.00 22.77 ? 113 CYS C N   1 
ATOM   5560 C  CA  . CYS C 1 108 ? -22.372 2.090   -22.579 1.00 23.96 ? 113 CYS C CA  1 
ATOM   5561 C  C   . CYS C 1 108 ? -23.012 1.634   -21.265 1.00 23.90 ? 113 CYS C C   1 
ATOM   5562 O  O   . CYS C 1 108 ? -22.701 0.550   -20.744 1.00 24.50 ? 113 CYS C O   1 
ATOM   5563 C  CB  . CYS C 1 108 ? -22.606 1.059   -23.694 1.00 23.90 ? 113 CYS C CB  1 
ATOM   5564 S  SG  . CYS C 1 108 ? -24.339 0.858   -24.090 1.00 28.25 ? 113 CYS C SG  1 
ATOM   5565 N  N   . VAL C 1 109 ? -23.894 2.479   -20.730 1.00 22.41 ? 114 VAL C N   1 
ATOM   5566 C  CA  . VAL C 1 109 ? -24.648 2.166   -19.521 1.00 21.41 ? 114 VAL C CA  1 
ATOM   5567 C  C   . VAL C 1 109 ? -26.025 1.663   -19.914 1.00 21.17 ? 114 VAL C C   1 
ATOM   5568 O  O   . VAL C 1 109 ? -26.793 2.395   -20.528 1.00 21.12 ? 114 VAL C O   1 
ATOM   5569 C  CB  . VAL C 1 109 ? -24.835 3.410   -18.613 1.00 20.88 ? 114 VAL C CB  1 
ATOM   5570 C  CG1 . VAL C 1 109 ? -25.799 3.082   -17.433 1.00 19.05 ? 114 VAL C CG1 1 
ATOM   5571 C  CG2 . VAL C 1 109 ? -23.509 3.897   -18.101 1.00 21.31 ? 114 VAL C CG2 1 
ATOM   5572 N  N   . THR C 1 110 ? -26.324 0.415   -19.575 1.00 21.03 ? 115 THR C N   1 
ATOM   5573 C  CA  . THR C 1 110 ? -27.651 -0.156  -19.813 1.00 20.15 ? 115 THR C CA  1 
ATOM   5574 C  C   . THR C 1 110 ? -28.324 -0.343  -18.473 1.00 21.51 ? 115 THR C C   1 
ATOM   5575 O  O   . THR C 1 110 ? -27.743 -0.952  -17.535 1.00 20.56 ? 115 THR C O   1 
ATOM   5576 C  CB  . THR C 1 110 ? -27.561 -1.518  -20.562 1.00 21.05 ? 115 THR C CB  1 
ATOM   5577 O  OG1 . THR C 1 110 ? -26.812 -1.344  -21.768 1.00 20.15 ? 115 THR C OG1 1 
ATOM   5578 C  CG2 . THR C 1 110 ? -28.957 -2.111  -20.928 1.00 18.19 ? 115 THR C CG2 1 
ATOM   5579 N  N   . LEU C 1 111 ? -29.547 0.184   -18.391 1.00 20.94 ? 116 LEU C N   1 
ATOM   5580 C  CA  . LEU C 1 111 ? -30.407 0.095   -17.215 1.00 20.99 ? 116 LEU C CA  1 
ATOM   5581 C  C   . LEU C 1 111 ? -31.369 -1.053  -17.412 1.00 21.31 ? 116 LEU C C   1 
ATOM   5582 O  O   . LEU C 1 111 ? -32.050 -1.123  -18.451 1.00 20.88 ? 116 LEU C O   1 
ATOM   5583 C  CB  . LEU C 1 111 ? -31.193 1.402   -17.039 1.00 20.91 ? 116 LEU C CB  1 
ATOM   5584 C  CG  . LEU C 1 111 ? -30.328 2.666   -16.979 1.00 20.64 ? 116 LEU C CG  1 
ATOM   5585 C  CD1 . LEU C 1 111 ? -31.151 3.934   -16.848 1.00 18.28 ? 116 LEU C CD1 1 
ATOM   5586 C  CD2 . LEU C 1 111 ? -29.305 2.601   -15.820 1.00 18.52 ? 116 LEU C CD2 1 
ATOM   5587 N  N   . GLY C 1 112 ? -31.406 -1.977  -16.451 1.00 20.18 ? 117 GLY C N   1 
ATOM   5588 C  CA  . GLY C 1 112 ? -32.377 -3.079  -16.512 1.00 20.92 ? 117 GLY C CA  1 
ATOM   5589 C  C   . GLY C 1 112 ? -33.604 -2.822  -15.661 1.00 20.36 ? 117 GLY C C   1 
ATOM   5590 O  O   . GLY C 1 112 ? -33.661 -1.806  -14.979 1.00 20.96 ? 117 GLY C O   1 
ATOM   5591 N  N   . GLY C 1 113 ? -34.601 -3.717  -15.674 1.00 20.98 ? 118 GLY C N   1 
ATOM   5592 C  CA  . GLY C 1 113 ? -34.575 -4.958  -16.426 1.00 21.00 ? 118 GLY C CA  1 
ATOM   5593 C  C   . GLY C 1 113 ? -33.814 -6.060  -15.723 1.00 21.15 ? 118 GLY C C   1 
ATOM   5594 O  O   . GLY C 1 113 ? -32.934 -5.772  -14.898 1.00 21.62 ? 118 GLY C O   1 
ATOM   5595 N  N   . ASP C 1 114 ? -34.172 -7.306  -16.008 1.00 20.27 ? 119 ASP C N   1 
ATOM   5596 C  CA  . ASP C 1 114 ? -33.558 -8.460  -15.331 1.00 20.67 ? 119 ASP C CA  1 
ATOM   5597 C  C   . ASP C 1 114 ? -32.192 -8.795  -15.927 1.00 19.29 ? 119 ASP C C   1 
ATOM   5598 O  O   . ASP C 1 114 ? -31.841 -8.273  -16.985 1.00 19.54 ? 119 ASP C O   1 
ATOM   5599 C  CB  . ASP C 1 114 ? -34.464 -9.701  -15.326 1.00 19.77 ? 119 ASP C CB  1 
ATOM   5600 C  CG  . ASP C 1 114 ? -34.693 -10.289 -16.723 1.00 22.79 ? 119 ASP C CG  1 
ATOM   5601 O  OD1 . ASP C 1 114 ? -33.746 -10.861 -17.312 1.00 21.26 ? 119 ASP C OD1 1 
ATOM   5602 O  OD2 . ASP C 1 114 ? -35.863 -10.218 -17.202 1.00 24.16 ? 119 ASP C OD2 1 
ATOM   5603 N  N   . HIS C 1 115 ? -31.462 -9.697  -15.278 1.00 19.71 ? 120 HIS C N   1 
ATOM   5604 C  CA  . HIS C 1 115 ? -30.046 -9.924  -15.636 1.00 19.27 ? 120 HIS C CA  1 
ATOM   5605 C  C   . HIS C 1 115 ? -29.829 -10.746 -16.925 1.00 19.35 ? 120 HIS C C   1 
ATOM   5606 O  O   . HIS C 1 115 ? -28.681 -10.833 -17.425 1.00 18.15 ? 120 HIS C O   1 
ATOM   5607 C  CB  . HIS C 1 115 ? -29.252 -10.551 -14.488 1.00 19.16 ? 120 HIS C CB  1 
ATOM   5608 C  CG  . HIS C 1 115 ? -27.850 -10.010 -14.361 1.00 19.88 ? 120 HIS C CG  1 
ATOM   5609 N  ND1 . HIS C 1 115 ? -27.168 -9.983  -13.166 1.00 18.69 ? 120 HIS C ND1 1 
ATOM   5610 C  CD2 . HIS C 1 115 ? -27.023 -9.447  -15.271 1.00 19.04 ? 120 HIS C CD2 1 
ATOM   5611 C  CE1 . HIS C 1 115 ? -25.987 -9.425  -13.341 1.00 19.63 ? 120 HIS C CE1 1 
ATOM   5612 N  NE2 . HIS C 1 115 ? -25.870 -9.097  -14.614 1.00 20.53 ? 120 HIS C NE2 1 
ATOM   5613 N  N   . SER C 1 116 ? -30.915 -11.320 -17.470 1.00 19.55 ? 121 SER C N   1 
ATOM   5614 C  CA  . SER C 1 116 ? -30.884 -11.947 -18.808 1.00 20.32 ? 121 SER C CA  1 
ATOM   5615 C  C   . SER C 1 116 ? -30.328 -10.977 -19.868 1.00 20.25 ? 121 SER C C   1 
ATOM   5616 O  O   . SER C 1 116 ? -29.751 -11.409 -20.849 1.00 21.16 ? 121 SER C O   1 
ATOM   5617 C  CB  . SER C 1 116 ? -32.278 -12.445 -19.245 1.00 20.73 ? 121 SER C CB  1 
ATOM   5618 O  OG  . SER C 1 116 ? -33.043 -11.372 -19.792 1.00 21.23 ? 121 SER C OG  1 
ATOM   5619 N  N   . LEU C 1 117 ? -30.470 -9.676  -19.642 1.00 20.27 ? 122 LEU C N   1 
ATOM   5620 C  CA  . LEU C 1 117 ? -30.025 -8.655  -20.610 1.00 20.96 ? 122 LEU C CA  1 
ATOM   5621 C  C   . LEU C 1 117 ? -28.504 -8.525  -20.745 1.00 20.59 ? 122 LEU C C   1 
ATOM   5622 O  O   . LEU C 1 117 ? -28.017 -7.890  -21.684 1.00 20.96 ? 122 LEU C O   1 
ATOM   5623 C  CB  . LEU C 1 117 ? -30.564 -7.289  -20.231 1.00 21.66 ? 122 LEU C CB  1 
ATOM   5624 C  CG  . LEU C 1 117 ? -32.063 -7.021  -20.216 1.00 25.38 ? 122 LEU C CG  1 
ATOM   5625 C  CD1 . LEU C 1 117 ? -32.291 -5.798  -19.324 1.00 27.42 ? 122 LEU C CD1 1 
ATOM   5626 C  CD2 . LEU C 1 117 ? -32.675 -6.801  -21.631 1.00 28.30 ? 122 LEU C CD2 1 
ATOM   5627 N  N   . ALA C 1 118 ? -27.753 -9.108  -19.818 1.00 19.12 ? 123 ALA C N   1 
ATOM   5628 C  CA  . ALA C 1 118 ? -26.291 -9.172  -20.017 1.00 19.55 ? 123 ALA C CA  1 
ATOM   5629 C  C   . ALA C 1 118 ? -25.900 -9.999  -21.274 1.00 18.94 ? 123 ALA C C   1 
ATOM   5630 O  O   . ALA C 1 118 ? -24.812 -9.827  -21.838 1.00 18.04 ? 123 ALA C O   1 
ATOM   5631 C  CB  . ALA C 1 118 ? -25.610 -9.725  -18.799 1.00 19.38 ? 123 ALA C CB  1 
ATOM   5632 N  N   . ILE C 1 119 ? -26.776 -10.912 -21.693 1.00 18.63 ? 124 ILE C N   1 
ATOM   5633 C  CA  . ILE C 1 119 ? -26.553 -11.664 -22.932 1.00 19.09 ? 124 ILE C CA  1 
ATOM   5634 C  C   . ILE C 1 119 ? -26.368 -10.662 -24.076 1.00 19.22 ? 124 ILE C C   1 
ATOM   5635 O  O   . ILE C 1 119 ? -25.351 -10.688 -24.799 1.00 17.97 ? 124 ILE C O   1 
ATOM   5636 C  CB  . ILE C 1 119 ? -27.712 -12.632 -23.240 1.00 19.36 ? 124 ILE C CB  1 
ATOM   5637 C  CG1 . ILE C 1 119 ? -27.738 -13.782 -22.215 1.00 19.63 ? 124 ILE C CG1 1 
ATOM   5638 C  CG2 . ILE C 1 119 ? -27.584 -13.227 -24.649 1.00 18.98 ? 124 ILE C CG2 1 
ATOM   5639 C  CD1 . ILE C 1 119 ? -29.041 -14.544 -22.225 1.00 18.65 ? 124 ILE C CD1 1 
ATOM   5640 N  N   . GLY C 1 120 ? -27.323 -9.742  -24.191 1.00 18.95 ? 125 GLY C N   1 
ATOM   5641 C  CA  . GLY C 1 120 ? -27.265 -8.708  -25.236 1.00 19.75 ? 125 GLY C CA  1 
ATOM   5642 C  C   . GLY C 1 120 ? -26.193 -7.649  -25.056 1.00 20.05 ? 125 GLY C C   1 
ATOM   5643 O  O   . GLY C 1 120 ? -25.502 -7.262  -26.035 1.00 20.94 ? 125 GLY C O   1 
ATOM   5644 N  N   . THR C 1 121 ? -26.012 -7.171  -23.819 1.00 19.03 ? 126 THR C N   1 
ATOM   5645 C  CA  . THR C 1 121 ? -25.027 -6.118  -23.590 1.00 17.35 ? 126 THR C CA  1 
ATOM   5646 C  C   . THR C 1 121 ? -23.581 -6.590  -23.783 1.00 17.48 ? 126 THR C C   1 
ATOM   5647 O  O   . THR C 1 121 ? -22.775 -5.846  -24.326 1.00 15.84 ? 126 THR C O   1 
ATOM   5648 C  CB  . THR C 1 121 ? -25.166 -5.394  -22.213 1.00 18.28 ? 126 THR C CB  1 
ATOM   5649 O  OG1 . THR C 1 121 ? -24.807 -6.288  -21.153 1.00 16.13 ? 126 THR C OG1 1 
ATOM   5650 C  CG2 . THR C 1 121 ? -26.588 -4.902  -21.990 1.00 17.01 ? 126 THR C CG2 1 
ATOM   5651 N  N   . ILE C 1 122 ? -23.263 -7.805  -23.333 1.00 17.57 ? 127 ILE C N   1 
ATOM   5652 C  CA  . ILE C 1 122 ? -21.918 -8.340  -23.485 1.00 18.00 ? 127 ILE C CA  1 
ATOM   5653 C  C   . ILE C 1 122 ? -21.630 -8.780  -24.952 1.00 18.78 ? 127 ILE C C   1 
ATOM   5654 O  O   . ILE C 1 122 ? -20.540 -8.532  -25.483 1.00 19.17 ? 127 ILE C O   1 
ATOM   5655 C  CB  . ILE C 1 122 ? -21.629 -9.456  -22.446 1.00 17.84 ? 127 ILE C CB  1 
ATOM   5656 C  CG1 . ILE C 1 122 ? -21.527 -8.838  -21.034 1.00 17.49 ? 127 ILE C CG1 1 
ATOM   5657 C  CG2 . ILE C 1 122 ? -20.338 -10.174 -22.798 1.00 15.87 ? 127 ILE C CG2 1 
ATOM   5658 C  CD1 . ILE C 1 122 ? -21.464 -9.885  -19.877 1.00 18.18 ? 127 ILE C CD1 1 
ATOM   5659 N  N   . SER C 1 123 ? -22.606 -9.432  -25.580 1.00 19.40 ? 128 SER C N   1 
ATOM   5660 C  CA  . SER C 1 123 ? -22.507 -9.810  -27.003 1.00 19.66 ? 128 SER C CA  1 
ATOM   5661 C  C   . SER C 1 123 ? -22.279 -8.561  -27.868 1.00 19.91 ? 128 SER C C   1 
ATOM   5662 O  O   . SER C 1 123 ? -21.384 -8.545  -28.683 1.00 20.76 ? 128 SER C O   1 
ATOM   5663 C  CB  . SER C 1 123 ? -23.784 -10.491 -27.468 1.00 18.82 ? 128 SER C CB  1 
ATOM   5664 O  OG  . SER C 1 123 ? -23.916 -11.754 -26.882 1.00 19.45 ? 128 SER C OG  1 
ATOM   5665 N  N   . GLY C 1 124 ? -23.086 -7.525  -27.663 1.00 20.06 ? 129 GLY C N   1 
ATOM   5666 C  CA  . GLY C 1 124 ? -22.922 -6.256  -28.375 1.00 19.53 ? 129 GLY C CA  1 
ATOM   5667 C  C   . GLY C 1 124 ? -21.581 -5.574  -28.182 1.00 20.19 ? 129 GLY C C   1 
ATOM   5668 O  O   . GLY C 1 124 ? -20.980 -5.077  -29.141 1.00 20.11 ? 129 GLY C O   1 
ATOM   5669 N  N   . HIS C 1 125 ? -21.136 -5.524  -26.931 1.00 19.18 ? 130 HIS C N   1 
ATOM   5670 C  CA  . HIS C 1 125 ? -19.843 -4.989  -26.543 1.00 20.10 ? 130 HIS C CA  1 
ATOM   5671 C  C   . HIS C 1 125 ? -18.697 -5.752  -27.211 1.00 18.96 ? 130 HIS C C   1 
ATOM   5672 O  O   . HIS C 1 125 ? -17.745 -5.146  -27.733 1.00 18.90 ? 130 HIS C O   1 
ATOM   5673 C  CB  . HIS C 1 125 ? -19.716 -5.117  -25.015 1.00 19.92 ? 130 HIS C CB  1 
ATOM   5674 C  CG  . HIS C 1 125 ? -18.656 -4.266  -24.397 1.00 20.33 ? 130 HIS C CG  1 
ATOM   5675 N  ND1 . HIS C 1 125 ? -18.500 -4.175  -23.026 1.00 18.29 ? 130 HIS C ND1 1 
ATOM   5676 C  CD2 . HIS C 1 125 ? -17.707 -3.458  -24.939 1.00 18.75 ? 130 HIS C CD2 1 
ATOM   5677 C  CE1 . HIS C 1 125 ? -17.515 -3.334  -22.749 1.00 19.58 ? 130 HIS C CE1 1 
ATOM   5678 N  NE2 . HIS C 1 125 ? -17.016 -2.886  -23.889 1.00 23.01 ? 130 HIS C NE2 1 
ATOM   5679 N  N   . ALA C 1 126 ? -18.782 -7.082  -27.171 1.00 19.78 ? 131 ALA C N   1 
ATOM   5680 C  CA  . ALA C 1 126 ? -17.745 -7.983  -27.717 1.00 20.81 ? 131 ALA C CA  1 
ATOM   5681 C  C   . ALA C 1 126 ? -17.512 -7.822  -29.233 1.00 21.80 ? 131 ALA C C   1 
ATOM   5682 O  O   . ALA C 1 126 ? -16.439 -8.128  -29.735 1.00 22.23 ? 131 ALA C O   1 
ATOM   5683 C  CB  . ALA C 1 126 ? -18.071 -9.446  -27.394 1.00 20.52 ? 131 ALA C CB  1 
ATOM   5684 N  N   . ARG C 1 127 ? -18.546 -7.362  -29.929 1.00 22.64 ? 132 ARG C N   1 
ATOM   5685 C  CA  . ARG C 1 127 ? -18.491 -7.024  -31.347 1.00 24.52 ? 132 ARG C CA  1 
ATOM   5686 C  C   . ARG C 1 127 ? -17.455 -5.959  -31.691 1.00 24.48 ? 132 ARG C C   1 
ATOM   5687 O  O   . ARG C 1 127 ? -17.113 -5.768  -32.879 1.00 23.79 ? 132 ARG C O   1 
ATOM   5688 C  CB  . ARG C 1 127 ? -19.882 -6.613  -31.843 1.00 24.60 ? 132 ARG C CB  1 
ATOM   5689 C  CG  . ARG C 1 127 ? -20.554 -7.712  -32.661 1.00 29.43 ? 132 ARG C CG  1 
ATOM   5690 C  CD  . ARG C 1 127 ? -21.862 -8.259  -32.101 1.00 32.69 ? 132 ARG C CD  1 
ATOM   5691 N  NE  . ARG C 1 127 ? -23.006 -7.433  -32.459 1.00 35.44 ? 132 ARG C NE  1 
ATOM   5692 C  CZ  . ARG C 1 127 ? -24.268 -7.849  -32.478 1.00 33.79 ? 132 ARG C CZ  1 
ATOM   5693 N  NH1 . ARG C 1 127 ? -25.227 -6.997  -32.795 1.00 34.60 ? 132 ARG C NH1 1 
ATOM   5694 N  NH2 . ARG C 1 127 ? -24.581 -9.101  -32.182 1.00 33.63 ? 132 ARG C NH2 1 
ATOM   5695 N  N   . HIS C 1 128 ? -16.921 -5.301  -30.655 1.00 23.78 ? 133 HIS C N   1 
ATOM   5696 C  CA  . HIS C 1 128 ? -15.979 -4.198  -30.825 1.00 23.57 ? 133 HIS C CA  1 
ATOM   5697 C  C   . HIS C 1 128 ? -14.734 -4.304  -29.953 1.00 23.61 ? 133 HIS C C   1 
ATOM   5698 O  O   . HIS C 1 128 ? -13.750 -3.576  -30.172 1.00 22.33 ? 133 HIS C O   1 
ATOM   5699 C  CB  . HIS C 1 128 ? -16.718 -2.853  -30.626 1.00 24.45 ? 133 HIS C CB  1 
ATOM   5700 C  CG  . HIS C 1 128 ? -17.920 -2.724  -31.505 1.00 23.27 ? 133 HIS C CG  1 
ATOM   5701 N  ND1 . HIS C 1 128 ? -17.821 -2.424  -32.847 1.00 24.78 ? 133 HIS C ND1 1 
ATOM   5702 C  CD2 . HIS C 1 128 ? -19.228 -2.989  -31.273 1.00 25.34 ? 133 HIS C CD2 1 
ATOM   5703 C  CE1 . HIS C 1 128 ? -19.026 -2.447  -33.386 1.00 27.17 ? 133 HIS C CE1 1 
ATOM   5704 N  NE2 . HIS C 1 128 ? -19.896 -2.790  -32.452 1.00 24.25 ? 133 HIS C NE2 1 
ATOM   5705 N  N   . CYS C 1 129 ? -14.760 -5.238  -29.001 1.00 23.16 ? 134 CYS C N   1 
ATOM   5706 C  CA  . CYS C 1 129 ? -13.675 -5.392  -28.040 1.00 23.28 ? 134 CYS C CA  1 
ATOM   5707 C  C   . CYS C 1 129 ? -13.301 -6.857  -27.881 1.00 23.02 ? 134 CYS C C   1 
ATOM   5708 O  O   . CYS C 1 129 ? -13.864 -7.530  -27.043 1.00 22.41 ? 134 CYS C O   1 
ATOM   5709 C  CB  . CYS C 1 129 ? -14.093 -4.849  -26.666 1.00 23.67 ? 134 CYS C CB  1 
ATOM   5710 S  SG  . CYS C 1 129 ? -14.582 -3.136  -26.666 1.00 22.99 ? 134 CYS C SG  1 
ATOM   5711 N  N   . PRO C 1 130 ? -12.330 -7.326  -28.673 1.00 23.27 ? 135 PRO C N   1 
ATOM   5712 C  CA  . PRO C 1 130 ? -11.921 -8.724  -28.703 1.00 23.10 ? 135 PRO C CA  1 
ATOM   5713 C  C   . PRO C 1 130 ? -11.293 -9.167  -27.382 1.00 23.33 ? 135 PRO C C   1 
ATOM   5714 O  O   . PRO C 1 130 ? -11.334 -10.359 -27.040 1.00 23.94 ? 135 PRO C O   1 
ATOM   5715 C  CB  . PRO C 1 130 ? -10.865 -8.764  -29.823 1.00 23.87 ? 135 PRO C CB  1 
ATOM   5716 C  CG  . PRO C 1 130 ? -10.449 -7.364  -30.034 1.00 22.05 ? 135 PRO C CG  1 
ATOM   5717 C  CD  . PRO C 1 130 ? -11.585 -6.504  -29.653 1.00 22.96 ? 135 PRO C CD  1 
ATOM   5718 N  N   . ASP C 1 131 ? -10.707 -8.227  -26.646 1.00 22.04 ? 136 ASP C N   1 
ATOM   5719 C  CA  . ASP C 1 131 ? -10.042 -8.591  -25.421 1.00 20.55 ? 136 ASP C CA  1 
ATOM   5720 C  C   . ASP C 1 131 ? -10.849 -8.092  -24.234 1.00 19.25 ? 136 ASP C C   1 
ATOM   5721 O  O   . ASP C 1 131 ? -10.286 -7.812  -23.190 1.00 17.88 ? 136 ASP C O   1 
ATOM   5722 C  CB  . ASP C 1 131 ? -8.604  -8.042  -25.407 1.00 20.41 ? 136 ASP C CB  1 
ATOM   5723 C  CG  . ASP C 1 131 ? -7.686  -8.841  -24.523 1.00 20.32 ? 136 ASP C CG  1 
ATOM   5724 O  OD1 . ASP C 1 131 ? -6.592  -8.343  -24.184 1.00 22.51 ? 136 ASP C OD1 1 
ATOM   5725 O  OD2 . ASP C 1 131 ? -8.048  -9.964  -24.146 1.00 20.28 ? 136 ASP C OD2 1 
ATOM   5726 N  N   . LEU C 1 132 ? -12.166 -7.991  -24.410 1.00 18.67 ? 137 LEU C N   1 
ATOM   5727 C  CA  . LEU C 1 132 ? -13.059 -7.574  -23.342 1.00 18.44 ? 137 LEU C CA  1 
ATOM   5728 C  C   . LEU C 1 132 ? -12.886 -8.491  -22.082 1.00 17.61 ? 137 LEU C C   1 
ATOM   5729 O  O   . LEU C 1 132 ? -12.719 -9.716  -22.215 1.00 15.97 ? 137 LEU C O   1 
ATOM   5730 C  CB  . LEU C 1 132 ? -14.491 -7.702  -23.857 1.00 18.94 ? 137 LEU C CB  1 
ATOM   5731 C  CG  . LEU C 1 132 ? -15.639 -7.357  -22.941 1.00 21.08 ? 137 LEU C CG  1 
ATOM   5732 C  CD1 . LEU C 1 132 ? -15.477 -5.894  -22.506 1.00 21.63 ? 137 LEU C CD1 1 
ATOM   5733 C  CD2 . LEU C 1 132 ? -16.982 -7.589  -23.619 1.00 16.76 ? 137 LEU C CD2 1 
ATOM   5734 N  N   . CYS C 1 133 ? -12.956 -7.894  -20.886 1.00 16.04 ? 138 CYS C N   1 
ATOM   5735 C  CA  . CYS C 1 133 ? -13.107 -8.673  -19.660 1.00 15.33 ? 138 CYS C CA  1 
ATOM   5736 C  C   . CYS C 1 133 ? -14.344 -8.214  -18.897 1.00 14.89 ? 138 CYS C C   1 
ATOM   5737 O  O   . CYS C 1 133 ? -14.846 -7.129  -19.132 1.00 13.75 ? 138 CYS C O   1 
ATOM   5738 C  CB  . CYS C 1 133 ? -11.880 -8.585  -18.768 1.00 16.60 ? 138 CYS C CB  1 
ATOM   5739 S  SG  . CYS C 1 133 ? -11.512 -6.971  -18.171 1.00 18.86 ? 138 CYS C SG  1 
ATOM   5740 N  N   . VAL C 1 134 ? -14.796 -9.037  -17.960 1.00 13.85 ? 139 VAL C N   1 
ATOM   5741 C  CA  . VAL C 1 134 ? -16.071 -8.810  -17.297 1.00 13.11 ? 139 VAL C CA  1 
ATOM   5742 C  C   . VAL C 1 134 ? -15.857 -8.886  -15.774 1.00 12.63 ? 139 VAL C C   1 
ATOM   5743 O  O   . VAL C 1 134 ? -15.198 -9.791  -15.280 1.00 13.12 ? 139 VAL C O   1 
ATOM   5744 C  CB  . VAL C 1 134 ? -17.081 -9.862  -17.713 1.00 12.95 ? 139 VAL C CB  1 
ATOM   5745 C  CG1 . VAL C 1 134 ? -18.436 -9.663  -16.976 1.00 12.73 ? 139 VAL C CG1 1 
ATOM   5746 C  CG2 . VAL C 1 134 ? -17.318 -9.838  -19.253 1.00 14.02 ? 139 VAL C CG2 1 
ATOM   5747 N  N   . VAL C 1 135 ? -16.402 -7.919  -15.048 1.00 12.42 ? 140 VAL C N   1 
ATOM   5748 C  CA  . VAL C 1 135 ? -16.475 -7.999  -13.598 1.00 11.25 ? 140 VAL C CA  1 
ATOM   5749 C  C   . VAL C 1 135 ? -17.974 -8.091  -13.360 1.00 11.86 ? 140 VAL C C   1 
ATOM   5750 O  O   . VAL C 1 135 ? -18.722 -7.181  -13.744 1.00 11.52 ? 140 VAL C O   1 
ATOM   5751 C  CB  . VAL C 1 135 ? -15.935 -6.752  -12.944 1.00 12.10 ? 140 VAL C CB  1 
ATOM   5752 C  CG1 . VAL C 1 135 ? -16.094 -6.844  -11.400 1.00 12.05 ? 140 VAL C CG1 1 
ATOM   5753 C  CG2 . VAL C 1 135 ? -14.404 -6.539  -13.336 1.00 11.25 ? 140 VAL C CG2 1 
ATOM   5754 N  N   . TRP C 1 136 ? -18.377 -9.175  -12.717 1.00 11.91 ? 141 TRP C N   1 
ATOM   5755 C  CA  . TRP C 1 136 ? -19.801 -9.486  -12.509 1.00 11.96 ? 141 TRP C CA  1 
ATOM   5756 C  C   . TRP C 1 136 ? -20.103 -9.399  -10.997 1.00 12.19 ? 141 TRP C C   1 
ATOM   5757 O  O   . TRP C 1 136 ? -19.638 -10.236 -10.193 1.00 12.67 ? 141 TRP C O   1 
ATOM   5758 C  CB  . TRP C 1 136 ? -20.090 -10.879 -13.102 1.00 12.32 ? 141 TRP C CB  1 
ATOM   5759 C  CG  . TRP C 1 136 ? -21.548 -11.279 -13.169 1.00 13.71 ? 141 TRP C CG  1 
ATOM   5760 C  CD1 . TRP C 1 136 ? -22.351 -11.622 -12.126 1.00 12.89 ? 141 TRP C CD1 1 
ATOM   5761 C  CD2 . TRP C 1 136 ? -22.350 -11.377 -14.358 1.00 14.74 ? 141 TRP C CD2 1 
ATOM   5762 N  NE1 . TRP C 1 136 ? -23.640 -11.919 -12.603 1.00 16.35 ? 141 TRP C NE1 1 
ATOM   5763 C  CE2 . TRP C 1 136 ? -23.649 -11.787 -13.966 1.00 15.07 ? 141 TRP C CE2 1 
ATOM   5764 C  CE3 . TRP C 1 136 ? -22.081 -11.184 -15.726 1.00 16.73 ? 141 TRP C CE3 1 
ATOM   5765 C  CZ2 . TRP C 1 136 ? -24.704 -11.991 -14.899 1.00 14.49 ? 141 TRP C CZ2 1 
ATOM   5766 C  CZ3 . TRP C 1 136 ? -23.124 -11.375 -16.657 1.00 15.73 ? 141 TRP C CZ3 1 
ATOM   5767 C  CH2 . TRP C 1 136 ? -24.426 -11.773 -16.229 1.00 15.09 ? 141 TRP C CH2 1 
ATOM   5768 N  N   . VAL C 1 137 ? -20.864 -8.369  -10.613 1.00 12.11 ? 142 VAL C N   1 
ATOM   5769 C  CA  . VAL C 1 137 ? -21.047 -8.032  -9.190  1.00 11.68 ? 142 VAL C CA  1 
ATOM   5770 C  C   . VAL C 1 137 ? -22.485 -8.425  -8.896  1.00 13.11 ? 142 VAL C C   1 
ATOM   5771 O  O   . VAL C 1 137 ? -23.411 -7.865  -9.476  1.00 13.72 ? 142 VAL C O   1 
ATOM   5772 C  CB  . VAL C 1 137 ? -20.809 -6.534  -8.884  1.00 11.14 ? 142 VAL C CB  1 
ATOM   5773 C  CG1 . VAL C 1 137 ? -21.095 -6.264  -7.376  1.00 10.10 ? 142 VAL C CG1 1 
ATOM   5774 C  CG2 . VAL C 1 137 ? -19.321 -6.128  -9.186  1.00 12.41 ? 142 VAL C CG2 1 
ATOM   5775 N  N   . ASP C 1 138 ? -22.656 -9.427  -8.044  1.00 13.06 ? 143 ASP C N   1 
ATOM   5776 C  CA  . ASP C 1 138 ? -23.954 -10.110 -7.974  1.00 13.38 ? 143 ASP C CA  1 
ATOM   5777 C  C   . ASP C 1 138 ? -23.966 -11.036 -6.787  1.00 13.00 ? 143 ASP C C   1 
ATOM   5778 O  O   . ASP C 1 138 ? -22.972 -11.662 -6.499  1.00 13.02 ? 143 ASP C O   1 
ATOM   5779 C  CB  . ASP C 1 138 ? -24.118 -10.944 -9.265  1.00 13.38 ? 143 ASP C CB  1 
ATOM   5780 C  CG  . ASP C 1 138 ? -25.587 -11.167 -9.652  1.00 14.20 ? 143 ASP C CG  1 
ATOM   5781 O  OD1 . ASP C 1 138 ? -26.424 -11.386 -8.770  1.00 9.81  ? 143 ASP C OD1 1 
ATOM   5782 O  OD2 . ASP C 1 138 ? -25.873 -11.169 -10.845 1.00 14.25 ? 143 ASP C OD2 1 
ATOM   5783 N  N   . ALA C 1 139 ? -25.108 -11.177 -6.122  1.00 13.78 ? 144 ALA C N   1 
ATOM   5784 C  CA  . ALA C 1 139 ? -25.323 -12.308 -5.216  1.00 14.46 ? 144 ALA C CA  1 
ATOM   5785 C  C   . ALA C 1 139 ? -25.273 -13.684 -5.915  1.00 14.30 ? 144 ALA C C   1 
ATOM   5786 O  O   . ALA C 1 139 ? -25.118 -14.736 -5.269  1.00 14.88 ? 144 ALA C O   1 
ATOM   5787 C  CB  . ALA C 1 139 ? -26.712 -12.138 -4.512  1.00 14.30 ? 144 ALA C CB  1 
ATOM   5788 N  N   . HIS C 1 140 ? -25.460 -13.687 -7.228  1.00 15.40 ? 145 HIS C N   1 
ATOM   5789 C  CA  . HIS C 1 140 ? -25.698 -14.929 -8.006  1.00 15.08 ? 145 HIS C CA  1 
ATOM   5790 C  C   . HIS C 1 140 ? -24.696 -15.033 -9.135  1.00 14.68 ? 145 HIS C C   1 
ATOM   5791 O  O   . HIS C 1 140 ? -24.284 -14.018 -9.662  1.00 15.19 ? 145 HIS C O   1 
ATOM   5792 C  CB  . HIS C 1 140 ? -27.096 -14.900 -8.634  1.00 15.60 ? 145 HIS C CB  1 
ATOM   5793 C  CG  . HIS C 1 140 ? -28.173 -14.648 -7.640  1.00 17.10 ? 145 HIS C CG  1 
ATOM   5794 N  ND1 . HIS C 1 140 ? -28.761 -13.415 -7.474  1.00 16.94 ? 145 HIS C ND1 1 
ATOM   5795 C  CD2 . HIS C 1 140 ? -28.771 -15.478 -6.761  1.00 16.23 ? 145 HIS C CD2 1 
ATOM   5796 C  CE1 . HIS C 1 140 ? -29.653 -13.494 -6.505  1.00 17.04 ? 145 HIS C CE1 1 
ATOM   5797 N  NE2 . HIS C 1 140 ? -29.671 -14.731 -6.053  1.00 15.94 ? 145 HIS C NE2 1 
ATOM   5798 N  N   . ALA C 1 141 ? -24.277 -16.254 -9.471  1.00 14.55 ? 146 ALA C N   1 
ATOM   5799 C  CA  . ALA C 1 141 ? -23.331 -16.488 -10.559 1.00 15.76 ? 146 ALA C CA  1 
ATOM   5800 C  C   . ALA C 1 141 ? -24.021 -16.427 -11.948 1.00 16.23 ? 146 ALA C C   1 
ATOM   5801 O  O   . ALA C 1 141 ? -23.377 -16.103 -12.959 1.00 15.20 ? 146 ALA C O   1 
ATOM   5802 C  CB  . ALA C 1 141 ? -22.625 -17.848 -10.362 1.00 15.70 ? 146 ALA C CB  1 
ATOM   5803 N  N   . ASP C 1 142 ? -25.332 -16.671 -11.981 1.00 15.44 ? 147 ASP C N   1 
ATOM   5804 C  CA  . ASP C 1 142 ? -26.124 -16.611 -13.239 1.00 16.12 ? 147 ASP C CA  1 
ATOM   5805 C  C   . ASP C 1 142 ? -25.478 -17.386 -14.390 1.00 16.89 ? 147 ASP C C   1 
ATOM   5806 O  O   . ASP C 1 142 ? -25.345 -16.904 -15.550 1.00 17.28 ? 147 ASP C O   1 
ATOM   5807 C  CB  . ASP C 1 142 ? -26.378 -15.162 -13.623 1.00 15.96 ? 147 ASP C CB  1 
ATOM   5808 C  CG  . ASP C 1 142 ? -27.233 -14.448 -12.591 1.00 18.18 ? 147 ASP C CG  1 
ATOM   5809 O  OD1 . ASP C 1 142 ? -27.890 -15.118 -11.785 1.00 18.24 ? 147 ASP C OD1 1 
ATOM   5810 O  OD2 . ASP C 1 142 ? -27.263 -13.231 -12.601 1.00 18.91 ? 147 ASP C OD2 1 
ATOM   5811 N  N   . ILE C 1 143 ? -25.029 -18.579 -14.049 1.00 17.56 ? 148 ILE C N   1 
ATOM   5812 C  CA  . ILE C 1 143 ? -24.246 -19.382 -14.956 1.00 17.75 ? 148 ILE C CA  1 
ATOM   5813 C  C   . ILE C 1 143 ? -24.816 -20.807 -15.112 1.00 18.34 ? 148 ILE C C   1 
ATOM   5814 O  O   . ILE C 1 143 ? -24.181 -21.667 -15.714 1.00 18.58 ? 148 ILE C O   1 
ATOM   5815 C  CB  . ILE C 1 143 ? -22.776 -19.410 -14.508 1.00 17.51 ? 148 ILE C CB  1 
ATOM   5816 C  CG1 . ILE C 1 143 ? -21.869 -19.820 -15.684 1.00 18.27 ? 148 ILE C CG1 1 
ATOM   5817 C  CG2 . ILE C 1 143 ? -22.622 -20.260 -13.226 1.00 15.32 ? 148 ILE C CG2 1 
ATOM   5818 C  CD1 . ILE C 1 143 ? -20.379 -19.537 -15.498 1.00 17.80 ? 148 ILE C CD1 1 
ATOM   5819 N  N   . ASN C 1 144 ? -26.018 -21.050 -14.605 1.00 18.96 ? 149 ASN C N   1 
ATOM   5820 C  CA  . ASN C 1 144 ? -26.733 -22.269 -15.013 1.00 19.49 ? 149 ASN C CA  1 
ATOM   5821 C  C   . ASN C 1 144 ? -26.822 -22.359 -16.537 1.00 20.24 ? 149 ASN C C   1 
ATOM   5822 O  O   . ASN C 1 144 ? -26.970 -21.345 -17.214 1.00 19.49 ? 149 ASN C O   1 
ATOM   5823 C  CB  . ASN C 1 144 ? -28.149 -22.317 -14.407 1.00 19.14 ? 149 ASN C CB  1 
ATOM   5824 C  CG  . ASN C 1 144 ? -28.141 -22.847 -12.996 1.00 19.65 ? 149 ASN C CG  1 
ATOM   5825 O  OD1 . ASN C 1 144 ? -27.642 -23.951 -12.740 1.00 21.33 ? 149 ASN C OD1 1 
ATOM   5826 N  ND2 . ASN C 1 144 ? -28.644 -22.048 -12.057 1.00 19.01 ? 149 ASN C ND2 1 
ATOM   5827 N  N   . THR C 1 145 ? -26.663 -23.561 -17.081 1.00 20.93 ? 150 THR C N   1 
ATOM   5828 C  CA  . THR C 1 145 ? -26.980 -23.770 -18.495 1.00 21.44 ? 150 THR C CA  1 
ATOM   5829 C  C   . THR C 1 145 ? -28.505 -24.033 -18.569 1.00 22.80 ? 150 THR C C   1 
ATOM   5830 O  O   . THR C 1 145 ? -29.142 -24.164 -17.535 1.00 22.27 ? 150 THR C O   1 
ATOM   5831 C  CB  . THR C 1 145 ? -26.256 -24.966 -19.059 1.00 21.28 ? 150 THR C CB  1 
ATOM   5832 O  OG1 . THR C 1 145 ? -26.864 -26.163 -18.552 1.00 22.17 ? 150 THR C OG1 1 
ATOM   5833 C  CG2 . THR C 1 145 ? -24.721 -24.962 -18.703 1.00 21.62 ? 150 THR C CG2 1 
ATOM   5834 N  N   . PRO C 1 146 ? -29.091 -24.110 -19.785 1.00 22.82 ? 151 PRO C N   1 
ATOM   5835 C  CA  . PRO C 1 146 ? -30.502 -24.529 -19.854 1.00 23.57 ? 151 PRO C CA  1 
ATOM   5836 C  C   . PRO C 1 146 ? -30.783 -25.936 -19.355 1.00 23.28 ? 151 PRO C C   1 
ATOM   5837 O  O   . PRO C 1 146 ? -31.943 -26.260 -19.064 1.00 25.00 ? 151 PRO C O   1 
ATOM   5838 C  CB  . PRO C 1 146 ? -30.824 -24.410 -21.340 1.00 23.40 ? 151 PRO C CB  1 
ATOM   5839 C  CG  . PRO C 1 146 ? -29.918 -23.215 -21.768 1.00 22.95 ? 151 PRO C CG  1 
ATOM   5840 C  CD  . PRO C 1 146 ? -28.634 -23.561 -21.080 1.00 23.41 ? 151 PRO C CD  1 
ATOM   5841 N  N   . LEU C 1 147 ? -29.747 -26.742 -19.225 1.00 24.05 ? 152 LEU C N   1 
ATOM   5842 C  CA  . LEU C 1 147 ? -29.882 -28.093 -18.662 1.00 24.94 ? 152 LEU C CA  1 
ATOM   5843 C  C   . LEU C 1 147 ? -29.719 -28.176 -17.134 1.00 25.56 ? 152 LEU C C   1 
ATOM   5844 O  O   . LEU C 1 147 ? -30.294 -29.083 -16.513 1.00 25.66 ? 152 LEU C O   1 
ATOM   5845 C  CB  . LEU C 1 147 ? -28.918 -29.074 -19.353 1.00 24.38 ? 152 LEU C CB  1 
ATOM   5846 C  CG  . LEU C 1 147 ? -29.127 -29.139 -20.876 1.00 25.43 ? 152 LEU C CG  1 
ATOM   5847 C  CD1 . LEU C 1 147 ? -28.210 -30.162 -21.472 1.00 26.06 ? 152 LEU C CD1 1 
ATOM   5848 C  CD2 . LEU C 1 147 ? -30.578 -29.398 -21.270 1.00 26.62 ? 152 LEU C CD2 1 
ATOM   5849 N  N   . THR C 1 148 ? -28.960 -27.252 -16.530 1.00 25.33 ? 153 THR C N   1 
ATOM   5850 C  CA  . THR C 1 148 ? -28.721 -27.307 -15.077 1.00 25.44 ? 153 THR C CA  1 
ATOM   5851 C  C   . THR C 1 148 ? -29.679 -26.472 -14.245 1.00 26.24 ? 153 THR C C   1 
ATOM   5852 O  O   . THR C 1 148 ? -29.755 -26.651 -13.020 1.00 25.09 ? 153 THR C O   1 
ATOM   5853 C  CB  . THR C 1 148 ? -27.292 -26.873 -14.664 1.00 25.49 ? 153 THR C CB  1 
ATOM   5854 O  OG1 . THR C 1 148 ? -27.141 -25.466 -14.887 1.00 23.50 ? 153 THR C OG1 1 
ATOM   5855 C  CG2 . THR C 1 148 ? -26.230 -27.657 -15.421 1.00 26.08 ? 153 THR C CG2 1 
ATOM   5856 N  N   . THR C 1 149 ? -30.365 -25.531 -14.889 1.00 25.94 ? 154 THR C N   1 
ATOM   5857 C  CA  . THR C 1 149 ? -31.313 -24.654 -14.201 1.00 27.65 ? 154 THR C CA  1 
ATOM   5858 C  C   . THR C 1 149 ? -32.464 -25.414 -13.498 1.00 28.53 ? 154 THR C C   1 
ATOM   5859 O  O   . THR C 1 149 ? -32.998 -26.383 -14.044 1.00 28.89 ? 154 THR C O   1 
ATOM   5860 C  CB  . THR C 1 149 ? -31.875 -23.579 -15.186 1.00 27.30 ? 154 THR C CB  1 
ATOM   5861 O  OG1 . THR C 1 149 ? -32.760 -22.700 -14.497 1.00 27.54 ? 154 THR C OG1 1 
ATOM   5862 C  CG2 . THR C 1 149 ? -32.611 -24.229 -16.351 1.00 27.38 ? 154 THR C CG2 1 
ATOM   5863 N  N   . SER C 1 150 ? -32.819 -24.984 -12.283 1.00 28.89 ? 155 SER C N   1 
ATOM   5864 C  CA  . SER C 1 150 ? -33.983 -25.523 -11.567 1.00 30.15 ? 155 SER C CA  1 
ATOM   5865 C  C   . SER C 1 150 ? -35.249 -24.713 -11.822 1.00 29.96 ? 155 SER C C   1 
ATOM   5866 O  O   . SER C 1 150 ? -36.343 -25.265 -11.862 1.00 30.63 ? 155 SER C O   1 
ATOM   5867 C  CB  . SER C 1 150 ? -33.731 -25.554 -10.056 1.00 29.92 ? 155 SER C CB  1 
ATOM   5868 O  OG  . SER C 1 150 ? -32.541 -26.246 -9.762  1.00 32.47 ? 155 SER C OG  1 
ATOM   5869 N  N   . SER C 1 151 ? -35.086 -23.401 -11.978 1.00 29.52 ? 156 SER C N   1 
ATOM   5870 C  CA  . SER C 1 151 ? -36.202 -22.490 -12.214 1.00 29.48 ? 156 SER C CA  1 
ATOM   5871 C  C   . SER C 1 151 ? -36.562 -22.362 -13.674 1.00 29.13 ? 156 SER C C   1 
ATOM   5872 O  O   . SER C 1 151 ? -37.700 -22.061 -13.989 1.00 29.85 ? 156 SER C O   1 
ATOM   5873 C  CB  . SER C 1 151 ? -35.884 -21.089 -11.677 1.00 29.40 ? 156 SER C CB  1 
ATOM   5874 O  OG  . SER C 1 151 ? -34.876 -20.475 -12.482 1.00 27.88 ? 156 SER C OG  1 
ATOM   5875 N  N   . GLY C 1 152 ? -35.586 -22.537 -14.564 1.00 28.11 ? 157 GLY C N   1 
ATOM   5876 C  CA  . GLY C 1 152 ? -35.813 -22.280 -15.978 1.00 27.34 ? 157 GLY C CA  1 
ATOM   5877 C  C   . GLY C 1 152 ? -35.772 -20.799 -16.349 1.00 27.14 ? 157 GLY C C   1 
ATOM   5878 O  O   . GLY C 1 152 ? -35.970 -20.448 -17.520 1.00 27.24 ? 157 GLY C O   1 
ATOM   5879 N  N   . ASN C 1 153 ? -35.515 -19.941 -15.360 1.00 25.76 ? 158 ASN C N   1 
ATOM   5880 C  CA  . ASN C 1 153 ? -35.468 -18.479 -15.560 1.00 25.50 ? 158 ASN C CA  1 
ATOM   5881 C  C   . ASN C 1 153 ? -34.133 -18.067 -16.181 1.00 24.83 ? 158 ASN C C   1 
ATOM   5882 O  O   . ASN C 1 153 ? -33.070 -18.389 -15.643 1.00 23.55 ? 158 ASN C O   1 
ATOM   5883 C  CB  . ASN C 1 153 ? -35.677 -17.734 -14.238 1.00 25.69 ? 158 ASN C CB  1 
ATOM   5884 C  CG  . ASN C 1 153 ? -37.053 -17.965 -13.636 1.00 26.79 ? 158 ASN C CG  1 
ATOM   5885 O  OD1 . ASN C 1 153 ? -38.001 -18.286 -14.351 1.00 27.36 ? 158 ASN C OD1 1 
ATOM   5886 N  ND2 . ASN C 1 153 ? -37.161 -17.824 -12.309 1.00 26.34 ? 158 ASN C ND2 1 
ATOM   5887 N  N   . LEU C 1 154 ? -34.196 -17.367 -17.311 1.00 24.39 ? 159 LEU C N   1 
ATOM   5888 C  CA  . LEU C 1 154 ? -32.980 -17.085 -18.089 1.00 24.04 ? 159 LEU C CA  1 
ATOM   5889 C  C   . LEU C 1 154 ? -32.134 -15.997 -17.461 1.00 23.47 ? 159 LEU C C   1 
ATOM   5890 O  O   . LEU C 1 154 ? -30.957 -15.835 -17.819 1.00 23.35 ? 159 LEU C O   1 
ATOM   5891 C  CB  . LEU C 1 154 ? -33.296 -16.771 -19.564 1.00 24.85 ? 159 LEU C CB  1 
ATOM   5892 C  CG  . LEU C 1 154 ? -33.664 -18.037 -20.379 1.00 24.55 ? 159 LEU C CG  1 
ATOM   5893 C  CD1 . LEU C 1 154 ? -34.586 -17.669 -21.523 1.00 24.56 ? 159 LEU C CD1 1 
ATOM   5894 C  CD2 . LEU C 1 154 ? -32.430 -18.745 -20.915 1.00 24.65 ? 159 LEU C CD2 1 
ATOM   5895 N  N   . HIS C 1 155 ? -32.696 -15.275 -16.492 1.00 22.10 ? 160 HIS C N   1 
ATOM   5896 C  CA  . HIS C 1 155 ? -31.859 -14.321 -15.780 1.00 21.79 ? 160 HIS C CA  1 
ATOM   5897 C  C   . HIS C 1 155 ? -30.805 -15.024 -14.915 1.00 21.03 ? 160 HIS C C   1 
ATOM   5898 O  O   . HIS C 1 155 ? -29.827 -14.384 -14.494 1.00 20.76 ? 160 HIS C O   1 
ATOM   5899 C  CB  . HIS C 1 155 ? -32.690 -13.252 -15.028 1.00 22.23 ? 160 HIS C CB  1 
ATOM   5900 C  CG  . HIS C 1 155 ? -33.261 -13.715 -13.725 1.00 21.54 ? 160 HIS C CG  1 
ATOM   5901 N  ND1 . HIS C 1 155 ? -33.502 -12.850 -12.680 1.00 22.80 ? 160 HIS C ND1 1 
ATOM   5902 C  CD2 . HIS C 1 155 ? -33.629 -14.945 -13.290 1.00 22.98 ? 160 HIS C CD2 1 
ATOM   5903 C  CE1 . HIS C 1 155 ? -34.022 -13.522 -11.666 1.00 22.90 ? 160 HIS C CE1 1 
ATOM   5904 N  NE2 . HIS C 1 155 ? -34.100 -14.796 -12.006 1.00 21.22 ? 160 HIS C NE2 1 
ATOM   5905 N  N   . GLY C 1 156 ? -30.974 -16.335 -14.696 1.00 19.84 ? 161 GLY C N   1 
ATOM   5906 C  CA  . GLY C 1 156 ? -29.976 -17.142 -13.949 1.00 19.85 ? 161 GLY C CA  1 
ATOM   5907 C  C   . GLY C 1 156 ? -29.070 -17.984 -14.834 1.00 18.83 ? 161 GLY C C   1 
ATOM   5908 O  O   . GLY C 1 156 ? -28.292 -18.833 -14.356 1.00 18.82 ? 161 GLY C O   1 
ATOM   5909 N  N   . GLN C 1 157 ? -29.167 -17.730 -16.129 1.00 19.06 ? 162 GLN C N   1 
ATOM   5910 C  CA  . GLN C 1 157 ? -28.408 -18.441 -17.158 1.00 19.74 ? 162 GLN C CA  1 
ATOM   5911 C  C   . GLN C 1 157 ? -27.464 -17.610 -18.092 1.00 19.10 ? 162 GLN C C   1 
ATOM   5912 O  O   . GLN C 1 157 ? -26.780 -18.206 -18.927 1.00 19.14 ? 162 GLN C O   1 
ATOM   5913 C  CB  . GLN C 1 157 ? -29.383 -19.242 -18.037 1.00 19.73 ? 162 GLN C CB  1 
ATOM   5914 C  CG  . GLN C 1 157 ? -30.169 -20.319 -17.255 1.00 21.19 ? 162 GLN C CG  1 
ATOM   5915 C  CD  . GLN C 1 157 ? -31.322 -20.907 -18.064 1.00 22.91 ? 162 GLN C CD  1 
ATOM   5916 O  OE1 . GLN C 1 157 ? -31.115 -21.509 -19.113 1.00 22.89 ? 162 GLN C OE1 1 
ATOM   5917 N  NE2 . GLN C 1 157 ? -32.541 -20.720 -17.579 1.00 22.75 ? 162 GLN C NE2 1 
ATOM   5918 N  N   . PRO C 1 158 ? -27.446 -16.257 -17.981 1.00 19.04 ? 163 PRO C N   1 
ATOM   5919 C  CA  . PRO C 1 158 ? -26.847 -15.499 -19.100 1.00 18.55 ? 163 PRO C CA  1 
ATOM   5920 C  C   . PRO C 1 158 ? -25.413 -15.866 -19.443 1.00 18.58 ? 163 PRO C C   1 
ATOM   5921 O  O   . PRO C 1 158 ? -25.070 -15.881 -20.636 1.00 18.41 ? 163 PRO C O   1 
ATOM   5922 C  CB  . PRO C 1 158 ? -26.921 -14.024 -18.649 1.00 18.27 ? 163 PRO C CB  1 
ATOM   5923 C  CG  . PRO C 1 158 ? -27.142 -14.077 -17.146 1.00 17.73 ? 163 PRO C CG  1 
ATOM   5924 C  CD  . PRO C 1 158 ? -27.940 -15.348 -16.918 1.00 18.56 ? 163 PRO C CD  1 
ATOM   5925 N  N   . VAL C 1 159 ? -24.592 -16.143 -18.422 1.00 17.85 ? 164 VAL C N   1 
ATOM   5926 C  CA  . VAL C 1 159 ? -23.171 -16.368 -18.631 1.00 18.78 ? 164 VAL C CA  1 
ATOM   5927 C  C   . VAL C 1 159 ? -22.929 -17.690 -19.381 1.00 18.86 ? 164 VAL C C   1 
ATOM   5928 O  O   . VAL C 1 159 ? -21.932 -17.815 -20.098 1.00 19.64 ? 164 VAL C O   1 
ATOM   5929 C  CB  . VAL C 1 159 ? -22.352 -16.295 -17.300 1.00 18.35 ? 164 VAL C CB  1 
ATOM   5930 C  CG1 . VAL C 1 159 ? -20.833 -16.511 -17.537 1.00 16.87 ? 164 VAL C CG1 1 
ATOM   5931 C  CG2 . VAL C 1 159 ? -22.631 -14.940 -16.572 1.00 18.85 ? 164 VAL C CG2 1 
ATOM   5932 N  N   . SER C 1 160 ? -23.827 -18.664 -19.229 1.00 19.03 ? 165 SER C N   1 
ATOM   5933 C  CA  . SER C 1 160 ? -23.609 -19.939 -19.924 1.00 20.18 ? 165 SER C CA  1 
ATOM   5934 C  C   . SER C 1 160 ? -23.591 -19.758 -21.447 1.00 20.39 ? 165 SER C C   1 
ATOM   5935 O  O   . SER C 1 160 ? -22.884 -20.479 -22.131 1.00 19.95 ? 165 SER C O   1 
ATOM   5936 C  CB  . SER C 1 160 ? -24.637 -20.997 -19.541 1.00 18.70 ? 165 SER C CB  1 
ATOM   5937 O  OG  . SER C 1 160 ? -25.900 -20.717 -20.119 1.00 20.72 ? 165 SER C OG  1 
ATOM   5938 N  N   . PHE C 1 161 ? -24.385 -18.823 -21.963 1.00 20.90 ? 166 PHE C N   1 
ATOM   5939 C  CA  . PHE C 1 161 ? -24.426 -18.583 -23.417 1.00 22.67 ? 166 PHE C CA  1 
ATOM   5940 C  C   . PHE C 1 161 ? -23.216 -17.754 -23.931 1.00 22.72 ? 166 PHE C C   1 
ATOM   5941 O  O   . PHE C 1 161 ? -22.945 -17.738 -25.137 1.00 22.86 ? 166 PHE C O   1 
ATOM   5942 C  CB  . PHE C 1 161 ? -25.701 -17.849 -23.822 1.00 22.70 ? 166 PHE C CB  1 
ATOM   5943 C  CG  . PHE C 1 161 ? -26.967 -18.496 -23.339 1.00 25.37 ? 166 PHE C CG  1 
ATOM   5944 C  CD1 . PHE C 1 161 ? -27.583 -18.041 -22.193 1.00 23.89 ? 166 PHE C CD1 1 
ATOM   5945 C  CD2 . PHE C 1 161 ? -27.544 -19.563 -24.039 1.00 26.47 ? 166 PHE C CD2 1 
ATOM   5946 C  CE1 . PHE C 1 161 ? -28.771 -18.627 -21.739 1.00 25.83 ? 166 PHE C CE1 1 
ATOM   5947 C  CE2 . PHE C 1 161 ? -28.753 -20.162 -23.585 1.00 27.72 ? 166 PHE C CE2 1 
ATOM   5948 C  CZ  . PHE C 1 161 ? -29.346 -19.690 -22.439 1.00 25.83 ? 166 PHE C CZ  1 
ATOM   5949 N  N   . LEU C 1 162 ? -22.514 -17.080 -23.014 1.00 22.11 ? 167 LEU C N   1 
ATOM   5950 C  CA  . LEU C 1 162 ? -21.394 -16.212 -23.343 1.00 21.60 ? 167 LEU C CA  1 
ATOM   5951 C  C   . LEU C 1 162 ? -20.031 -16.883 -23.219 1.00 21.76 ? 167 LEU C C   1 
ATOM   5952 O  O   . LEU C 1 162 ? -19.091 -16.470 -23.886 1.00 21.83 ? 167 LEU C O   1 
ATOM   5953 C  CB  . LEU C 1 162 ? -21.420 -14.958 -22.449 1.00 21.34 ? 167 LEU C CB  1 
ATOM   5954 C  CG  . LEU C 1 162 ? -22.709 -14.136 -22.543 1.00 20.96 ? 167 LEU C CG  1 
ATOM   5955 C  CD1 . LEU C 1 162 ? -22.773 -13.026 -21.460 1.00 19.43 ? 167 LEU C CD1 1 
ATOM   5956 C  CD2 . LEU C 1 162 ? -22.897 -13.554 -23.961 1.00 18.97 ? 167 LEU C CD2 1 
ATOM   5957 N  N   . LEU C 1 163 ? -19.924 -17.918 -22.387 1.00 21.56 ? 168 LEU C N   1 
ATOM   5958 C  CA  . LEU C 1 163 ? -18.638 -18.517 -22.074 1.00 22.66 ? 168 LEU C CA  1 
ATOM   5959 C  C   . LEU C 1 163 ? -18.223 -19.570 -23.107 1.00 23.30 ? 168 LEU C C   1 
ATOM   5960 O  O   . LEU C 1 163 ? -18.970 -20.505 -23.372 1.00 21.73 ? 168 LEU C O   1 
ATOM   5961 C  CB  . LEU C 1 163 ? -18.648 -19.115 -20.667 1.00 22.33 ? 168 LEU C CB  1 
ATOM   5962 C  CG  . LEU C 1 163 ? -17.294 -19.120 -19.981 1.00 24.52 ? 168 LEU C CG  1 
ATOM   5963 C  CD1 . LEU C 1 163 ? -16.977 -17.711 -19.413 1.00 23.63 ? 168 LEU C CD1 1 
ATOM   5964 C  CD2 . LEU C 1 163 ? -17.311 -20.184 -18.867 1.00 25.20 ? 168 LEU C CD2 1 
ATOM   5965 N  N   . ARG C 1 164 ? -17.058 -19.377 -23.720 1.00 23.71 ? 169 ARG C N   1 
ATOM   5966 C  CA  . ARG C 1 164 ? -16.599 -20.292 -24.792 1.00 25.61 ? 169 ARG C CA  1 
ATOM   5967 C  C   . ARG C 1 164 ? -16.497 -21.748 -24.307 1.00 24.89 ? 169 ARG C C   1 
ATOM   5968 O  O   . ARG C 1 164 ? -16.895 -22.658 -25.019 1.00 24.04 ? 169 ARG C O   1 
ATOM   5969 C  CB  . ARG C 1 164 ? -15.256 -19.849 -25.383 1.00 25.63 ? 169 ARG C CB  1 
ATOM   5970 C  CG  . ARG C 1 164 ? -15.264 -18.454 -26.046 1.00 30.17 ? 169 ARG C CG  1 
ATOM   5971 C  CD  . ARG C 1 164 ? -13.950 -18.190 -26.804 1.00 35.10 ? 169 ARG C CD  1 
ATOM   5972 N  NE  . ARG C 1 164 ? -13.502 -16.795 -26.729 1.00 39.64 ? 169 ARG C NE  1 
ATOM   5973 C  CZ  . ARG C 1 164 ? -13.739 -15.856 -27.647 1.00 42.61 ? 169 ARG C CZ  1 
ATOM   5974 N  NH1 . ARG C 1 164 ? -14.429 -16.141 -28.745 1.00 45.27 ? 169 ARG C NH1 1 
ATOM   5975 N  NH2 . ARG C 1 164 ? -13.268 -14.623 -27.479 1.00 41.56 ? 169 ARG C NH2 1 
ATOM   5976 N  N   . GLU C 1 165 ? -15.963 -21.938 -23.100 1.00 24.94 ? 170 GLU C N   1 
ATOM   5977 C  CA  . GLU C 1 165 ? -15.757 -23.273 -22.511 1.00 25.30 ? 170 GLU C CA  1 
ATOM   5978 C  C   . GLU C 1 165 ? -17.036 -24.112 -22.322 1.00 25.28 ? 170 GLU C C   1 
ATOM   5979 O  O   . GLU C 1 165 ? -16.958 -25.341 -22.254 1.00 25.54 ? 170 GLU C O   1 
ATOM   5980 C  CB  . GLU C 1 165 ? -14.993 -23.185 -21.189 1.00 25.21 ? 170 GLU C CB  1 
ATOM   5981 C  CG  . GLU C 1 165 ? -13.546 -22.738 -21.318 1.00 24.65 ? 170 GLU C CG  1 
ATOM   5982 C  CD  . GLU C 1 165 ? -13.414 -21.197 -21.437 1.00 26.56 ? 170 GLU C CD  1 
ATOM   5983 O  OE1 . GLU C 1 165 ? -14.453 -20.483 -21.593 1.00 18.85 ? 170 GLU C OE1 1 
ATOM   5984 O  OE2 . GLU C 1 165 ? -12.263 -20.728 -21.391 1.00 26.19 ? 170 GLU C OE2 1 
ATOM   5985 N  N   . LEU C 1 166 ? -18.183 -23.453 -22.229 1.00 24.68 ? 171 LEU C N   1 
ATOM   5986 C  CA  . LEU C 1 166 ? -19.471 -24.117 -21.996 1.00 25.80 ? 171 LEU C CA  1 
ATOM   5987 C  C   . LEU C 1 166 ? -20.269 -24.418 -23.268 1.00 25.75 ? 171 LEU C C   1 
ATOM   5988 O  O   . LEU C 1 166 ? -21.396 -24.921 -23.190 1.00 25.60 ? 171 LEU C O   1 
ATOM   5989 C  CB  . LEU C 1 166 ? -20.354 -23.240 -21.087 1.00 24.94 ? 171 LEU C CB  1 
ATOM   5990 C  CG  . LEU C 1 166 ? -20.565 -23.519 -19.588 1.00 26.91 ? 171 LEU C CG  1 
ATOM   5991 C  CD1 . LEU C 1 166 ? -19.743 -24.690 -18.951 1.00 27.16 ? 171 LEU C CD1 1 
ATOM   5992 C  CD2 . LEU C 1 166 ? -20.518 -22.289 -18.743 1.00 24.33 ? 171 LEU C CD2 1 
ATOM   5993 N  N   . GLN C 1 167 ? -19.727 -24.061 -24.428 1.00 26.87 ? 172 GLN C N   1 
ATOM   5994 C  CA  . GLN C 1 167 ? -20.520 -24.121 -25.652 1.00 28.44 ? 172 GLN C CA  1 
ATOM   5995 C  C   . GLN C 1 167 ? -21.137 -25.521 -25.886 1.00 28.65 ? 172 GLN C C   1 
ATOM   5996 O  O   . GLN C 1 167 ? -22.300 -25.619 -26.200 1.00 29.89 ? 172 GLN C O   1 
ATOM   5997 C  CB  . GLN C 1 167 ? -19.695 -23.659 -26.850 1.00 27.80 ? 172 GLN C CB  1 
ATOM   5998 C  CG  . GLN C 1 167 ? -20.480 -23.647 -28.145 1.00 30.33 ? 172 GLN C CG  1 
ATOM   5999 C  CD  . GLN C 1 167 ? -19.727 -23.002 -29.309 1.00 33.32 ? 172 GLN C CD  1 
ATOM   6000 O  OE1 . GLN C 1 167 ? -18.570 -22.581 -29.182 1.00 33.11 ? 172 GLN C OE1 1 
ATOM   6001 N  NE2 . GLN C 1 167 ? -20.398 -22.912 -30.448 1.00 35.21 ? 172 GLN C NE2 1 
ATOM   6002 N  N   . ASP C 1 168 ? -20.349 -26.569 -25.681 1.00 30.71 ? 173 ASP C N   1 
ATOM   6003 C  CA  . ASP C 1 168 ? -20.780 -27.978 -25.822 1.00 32.69 ? 173 ASP C CA  1 
ATOM   6004 C  C   . ASP C 1 168 ? -21.841 -28.426 -24.804 1.00 32.80 ? 173 ASP C C   1 
ATOM   6005 O  O   . ASP C 1 168 ? -22.393 -29.518 -24.938 1.00 32.06 ? 173 ASP C O   1 
ATOM   6006 C  CB  . ASP C 1 168 ? -19.573 -28.924 -25.679 1.00 33.50 ? 173 ASP C CB  1 
ATOM   6007 C  CG  . ASP C 1 168 ? -18.578 -28.810 -26.831 1.00 38.19 ? 173 ASP C CG  1 
ATOM   6008 O  OD1 . ASP C 1 168 ? -18.919 -28.268 -27.920 1.00 41.75 ? 173 ASP C OD1 1 
ATOM   6009 O  OD2 . ASP C 1 168 ? -17.432 -29.292 -26.652 1.00 42.47 ? 173 ASP C OD2 1 
ATOM   6010 N  N   . LYS C 1 169 ? -22.091 -27.600 -23.784 1.00 31.95 ? 174 LYS C N   1 
ATOM   6011 C  CA  . LYS C 1 169 ? -22.977 -27.956 -22.680 1.00 31.81 ? 174 LYS C CA  1 
ATOM   6012 C  C   . LYS C 1 169 ? -24.276 -27.181 -22.788 1.00 31.32 ? 174 LYS C C   1 
ATOM   6013 O  O   . LYS C 1 169 ? -25.187 -27.376 -22.008 1.00 31.80 ? 174 LYS C O   1 
ATOM   6014 C  CB  . LYS C 1 169 ? -22.318 -27.665 -21.318 1.00 31.49 ? 174 LYS C CB  1 
ATOM   6015 C  CG  . LYS C 1 169 ? -20.931 -28.231 -21.143 1.00 33.04 ? 174 LYS C CG  1 
ATOM   6016 C  CD  . LYS C 1 169 ? -20.897 -29.761 -21.120 1.00 37.01 ? 174 LYS C CD  1 
ATOM   6017 C  CE  . LYS C 1 169 ? -19.468 -30.259 -21.137 1.00 37.90 ? 174 LYS C CE  1 
ATOM   6018 N  NZ  . LYS C 1 169 ? -19.363 -31.734 -20.870 1.00 40.45 ? 174 LYS C NZ  1 
ATOM   6019 N  N   . VAL C 1 170 ? -24.360 -26.292 -23.768 1.00 30.90 ? 175 VAL C N   1 
ATOM   6020 C  CA  . VAL C 1 170 ? -25.525 -25.455 -23.902 1.00 30.64 ? 175 VAL C CA  1 
ATOM   6021 C  C   . VAL C 1 170 ? -26.314 -25.863 -25.136 1.00 31.07 ? 175 VAL C C   1 
ATOM   6022 O  O   . VAL C 1 170 ? -25.780 -25.814 -26.243 1.00 31.15 ? 175 VAL C O   1 
ATOM   6023 C  CB  . VAL C 1 170 ? -25.122 -23.953 -23.967 1.00 30.62 ? 175 VAL C CB  1 
ATOM   6024 C  CG1 . VAL C 1 170 ? -26.338 -23.095 -24.213 1.00 30.08 ? 175 VAL C CG1 1 
ATOM   6025 C  CG2 . VAL C 1 170 ? -24.396 -23.534 -22.678 1.00 29.76 ? 175 VAL C CG2 1 
ATOM   6026 N  N   . PRO C 1 171 ? -27.580 -26.287 -24.952 1.00 31.72 ? 176 PRO C N   1 
ATOM   6027 C  CA  . PRO C 1 171 ? -28.423 -26.625 -26.098 1.00 32.49 ? 176 PRO C CA  1 
ATOM   6028 C  C   . PRO C 1 171 ? -28.863 -25.368 -26.834 1.00 33.58 ? 176 PRO C C   1 
ATOM   6029 O  O   . PRO C 1 171 ? -28.880 -24.274 -26.253 1.00 32.26 ? 176 PRO C O   1 
ATOM   6030 C  CB  . PRO C 1 171 ? -29.650 -27.282 -25.461 1.00 32.25 ? 176 PRO C CB  1 
ATOM   6031 C  CG  . PRO C 1 171 ? -29.710 -26.691 -24.081 1.00 32.07 ? 176 PRO C CG  1 
ATOM   6032 C  CD  . PRO C 1 171 ? -28.265 -26.541 -23.673 1.00 31.63 ? 176 PRO C CD  1 
ATOM   6033 N  N   . GLN C 1 172 ? -29.229 -25.535 -28.101 1.00 34.83 ? 177 GLN C N   1 
ATOM   6034 C  CA  . GLN C 1 172 ? -29.636 -24.408 -28.914 1.00 35.90 ? 177 GLN C CA  1 
ATOM   6035 C  C   . GLN C 1 172 ? -31.089 -24.107 -28.553 1.00 35.38 ? 177 GLN C C   1 
ATOM   6036 O  O   . GLN C 1 172 ? -31.963 -24.957 -28.745 1.00 35.65 ? 177 GLN C O   1 
ATOM   6037 C  CB  . GLN C 1 172 ? -29.482 -24.755 -30.397 1.00 37.35 ? 177 GLN C CB  1 
ATOM   6038 C  CG  . GLN C 1 172 ? -29.234 -23.532 -31.280 1.00 41.62 ? 177 GLN C CG  1 
ATOM   6039 C  CD  . GLN C 1 172 ? -29.559 -23.783 -32.743 1.00 46.74 ? 177 GLN C CD  1 
ATOM   6040 O  OE1 . GLN C 1 172 ? -29.750 -24.932 -33.172 1.00 49.39 ? 177 GLN C OE1 1 
ATOM   6041 N  NE2 . GLN C 1 172 ? -29.625 -22.705 -33.519 1.00 47.80 ? 177 GLN C NE2 1 
ATOM   6042 N  N   . LEU C 1 173 ? -31.343 -22.936 -27.965 1.00 33.88 ? 178 LEU C N   1 
ATOM   6043 C  CA  . LEU C 1 173 ? -32.707 -22.546 -27.597 1.00 33.39 ? 178 LEU C CA  1 
ATOM   6044 C  C   . LEU C 1 173 ? -33.338 -21.742 -28.732 1.00 33.18 ? 178 LEU C C   1 
ATOM   6045 O  O   . LEU C 1 173 ? -32.615 -21.104 -29.478 1.00 32.17 ? 178 LEU C O   1 
ATOM   6046 C  CB  . LEU C 1 173 ? -32.711 -21.701 -26.315 1.00 32.58 ? 178 LEU C CB  1 
ATOM   6047 C  CG  . LEU C 1 173 ? -32.309 -22.409 -25.030 1.00 32.52 ? 178 LEU C CG  1 
ATOM   6048 C  CD1 . LEU C 1 173 ? -32.124 -21.382 -23.952 1.00 31.10 ? 178 LEU C CD1 1 
ATOM   6049 C  CD2 . LEU C 1 173 ? -33.353 -23.466 -24.624 1.00 31.40 ? 178 LEU C CD2 1 
ATOM   6050 N  N   . PRO C 1 174 ? -34.682 -21.775 -28.858 1.00 33.34 ? 179 PRO C N   1 
ATOM   6051 C  CA  . PRO C 1 174 ? -35.307 -20.934 -29.880 1.00 33.23 ? 179 PRO C CA  1 
ATOM   6052 C  C   . PRO C 1 174 ? -35.092 -19.450 -29.602 1.00 32.74 ? 179 PRO C C   1 
ATOM   6053 O  O   . PRO C 1 174 ? -35.300 -18.992 -28.474 1.00 31.78 ? 179 PRO C O   1 
ATOM   6054 C  CB  . PRO C 1 174 ? -36.791 -21.272 -29.794 1.00 33.19 ? 179 PRO C CB  1 
ATOM   6055 C  CG  . PRO C 1 174 ? -36.977 -22.076 -28.555 1.00 34.55 ? 179 PRO C CG  1 
ATOM   6056 C  CD  . PRO C 1 174 ? -35.650 -22.682 -28.213 1.00 34.28 ? 179 PRO C CD  1 
ATOM   6057 N  N   . GLY C 1 175 ? -34.695 -18.726 -30.646 1.00 31.99 ? 180 GLY C N   1 
ATOM   6058 C  CA  . GLY C 1 175 ? -34.405 -17.306 -30.560 1.00 31.38 ? 180 GLY C CA  1 
ATOM   6059 C  C   . GLY C 1 175 ? -32.963 -17.032 -30.169 1.00 31.24 ? 180 GLY C C   1 
ATOM   6060 O  O   . GLY C 1 175 ? -32.555 -15.882 -30.121 1.00 30.89 ? 180 GLY C O   1 
ATOM   6061 N  N   . PHE C 1 176 ? -32.194 -18.084 -29.886 1.00 31.49 ? 181 PHE C N   1 
ATOM   6062 C  CA  . PHE C 1 176 ? -30.815 -17.929 -29.422 1.00 31.84 ? 181 PHE C CA  1 
ATOM   6063 C  C   . PHE C 1 176 ? -29.755 -18.279 -30.467 1.00 32.16 ? 181 PHE C C   1 
ATOM   6064 O  O   . PHE C 1 176 ? -28.563 -18.295 -30.153 1.00 31.55 ? 181 PHE C O   1 
ATOM   6065 C  CB  . PHE C 1 176 ? -30.576 -18.767 -28.157 1.00 31.78 ? 181 PHE C CB  1 
ATOM   6066 C  CG  . PHE C 1 176 ? -31.083 -18.126 -26.888 1.00 32.47 ? 181 PHE C CG  1 
ATOM   6067 C  CD1 . PHE C 1 176 ? -32.441 -17.957 -26.671 1.00 32.08 ? 181 PHE C CD1 1 
ATOM   6068 C  CD2 . PHE C 1 176 ? -30.196 -17.743 -25.890 1.00 32.82 ? 181 PHE C CD2 1 
ATOM   6069 C  CE1 . PHE C 1 176 ? -32.910 -17.369 -25.496 1.00 33.03 ? 181 PHE C CE1 1 
ATOM   6070 C  CE2 . PHE C 1 176 ? -30.659 -17.150 -24.719 1.00 33.00 ? 181 PHE C CE2 1 
ATOM   6071 C  CZ  . PHE C 1 176 ? -32.018 -16.966 -24.526 1.00 30.88 ? 181 PHE C CZ  1 
ATOM   6072 N  N   . SER C 1 177 ? -30.166 -18.559 -31.701 1.00 32.71 ? 182 SER C N   1 
ATOM   6073 C  CA  . SER C 1 177 ? -29.193 -19.001 -32.722 1.00 33.81 ? 182 SER C CA  1 
ATOM   6074 C  C   . SER C 1 177 ? -28.122 -17.941 -33.046 1.00 33.78 ? 182 SER C C   1 
ATOM   6075 O  O   . SER C 1 177 ? -27.002 -18.287 -33.420 1.00 34.61 ? 182 SER C O   1 
ATOM   6076 C  CB  . SER C 1 177 ? -29.900 -19.470 -34.008 1.00 33.58 ? 182 SER C CB  1 
ATOM   6077 O  OG  . SER C 1 177 ? -30.630 -18.407 -34.609 1.00 34.66 ? 182 SER C OG  1 
ATOM   6078 N  N   . TRP C 1 178 ? -28.460 -16.665 -32.872 1.00 33.49 ? 183 TRP C N   1 
ATOM   6079 C  CA  . TRP C 1 178 ? -27.563 -15.554 -33.210 1.00 33.12 ? 183 TRP C CA  1 
ATOM   6080 C  C   . TRP C 1 178 ? -26.378 -15.385 -32.237 1.00 33.14 ? 183 TRP C C   1 
ATOM   6081 O  O   . TRP C 1 178 ? -25.446 -14.666 -32.545 1.00 31.90 ? 183 TRP C O   1 
ATOM   6082 C  CB  . TRP C 1 178 ? -28.348 -14.233 -33.254 1.00 32.93 ? 183 TRP C CB  1 
ATOM   6083 C  CG  . TRP C 1 178 ? -28.888 -13.866 -31.888 1.00 32.60 ? 183 TRP C CG  1 
ATOM   6084 C  CD1 . TRP C 1 178 ? -30.064 -14.302 -31.330 1.00 31.62 ? 183 TRP C CD1 1 
ATOM   6085 C  CD2 . TRP C 1 178 ? -28.253 -13.043 -30.891 1.00 30.67 ? 183 TRP C CD2 1 
ATOM   6086 N  NE1 . TRP C 1 178 ? -30.203 -13.796 -30.069 1.00 31.50 ? 183 TRP C NE1 1 
ATOM   6087 C  CE2 . TRP C 1 178 ? -29.108 -13.030 -29.762 1.00 30.37 ? 183 TRP C CE2 1 
ATOM   6088 C  CE3 . TRP C 1 178 ? -27.034 -12.334 -30.832 1.00 27.78 ? 183 TRP C CE3 1 
ATOM   6089 C  CZ2 . TRP C 1 178 ? -28.797 -12.323 -28.585 1.00 27.75 ? 183 TRP C CZ2 1 
ATOM   6090 C  CZ3 . TRP C 1 178 ? -26.724 -11.622 -29.656 1.00 26.51 ? 183 TRP C CZ3 1 
ATOM   6091 C  CH2 . TRP C 1 178 ? -27.622 -11.610 -28.560 1.00 27.70 ? 183 TRP C CH2 1 
ATOM   6092 N  N   . ILE C 1 179 ? -26.411 -16.028 -31.070 1.00 32.88 ? 184 ILE C N   1 
ATOM   6093 C  CA  . ILE C 1 179 ? -25.372 -15.742 -30.060 1.00 33.95 ? 184 ILE C CA  1 
ATOM   6094 C  C   . ILE C 1 179 ? -24.062 -16.469 -30.324 1.00 33.92 ? 184 ILE C C   1 
ATOM   6095 O  O   . ILE C 1 179 ? -24.048 -17.642 -30.645 1.00 35.02 ? 184 ILE C O   1 
ATOM   6096 C  CB  . ILE C 1 179 ? -25.857 -15.983 -28.595 1.00 34.08 ? 184 ILE C CB  1 
ATOM   6097 C  CG1 . ILE C 1 179 ? -27.149 -15.212 -28.355 1.00 33.66 ? 184 ILE C CG1 1 
ATOM   6098 C  CG2 . ILE C 1 179 ? -24.796 -15.469 -27.586 1.00 34.38 ? 184 ILE C CG2 1 
ATOM   6099 C  CD1 . ILE C 1 179 ? -27.967 -15.645 -27.161 1.00 33.69 ? 184 ILE C CD1 1 
ATOM   6100 N  N   . LYS C 1 180 ? -22.954 -15.754 -30.216 1.00 33.89 ? 185 LYS C N   1 
ATOM   6101 C  CA  . LYS C 1 180 ? -21.641 -16.368 -30.320 1.00 34.21 ? 185 LYS C CA  1 
ATOM   6102 C  C   . LYS C 1 180 ? -20.950 -16.219 -28.959 1.00 33.04 ? 185 LYS C C   1 
ATOM   6103 O  O   . LYS C 1 180 ? -20.774 -15.102 -28.498 1.00 31.62 ? 185 LYS C O   1 
ATOM   6104 C  CB  . LYS C 1 180 ? -20.799 -15.669 -31.408 1.00 35.32 ? 185 LYS C CB  1 
ATOM   6105 C  CG  . LYS C 1 180 ? -21.333 -15.789 -32.869 1.00 39.62 ? 185 LYS C CG  1 
ATOM   6106 C  CD  . LYS C 1 180 ? -20.717 -14.702 -33.782 1.00 44.81 ? 185 LYS C CD  1 
ATOM   6107 C  CE  . LYS C 1 180 ? -20.941 -14.962 -35.273 1.00 47.10 ? 185 LYS C CE  1 
ATOM   6108 N  NZ  . LYS C 1 180 ? -22.338 -14.652 -35.708 1.00 49.78 ? 185 LYS C NZ  1 
ATOM   6109 N  N   . PRO C 1 181 ? -20.562 -17.346 -28.311 1.00 32.83 ? 186 PRO C N   1 
ATOM   6110 C  CA  . PRO C 1 181 ? -19.726 -17.238 -27.102 1.00 32.14 ? 186 PRO C CA  1 
ATOM   6111 C  C   . PRO C 1 181 ? -18.582 -16.248 -27.364 1.00 31.67 ? 186 PRO C C   1 
ATOM   6112 O  O   . PRO C 1 181 ? -17.986 -16.284 -28.434 1.00 30.56 ? 186 PRO C O   1 
ATOM   6113 C  CB  . PRO C 1 181 ? -19.173 -18.653 -26.938 1.00 32.44 ? 186 PRO C CB  1 
ATOM   6114 C  CG  . PRO C 1 181 ? -20.196 -19.522 -27.542 1.00 33.08 ? 186 PRO C CG  1 
ATOM   6115 C  CD  . PRO C 1 181 ? -20.771 -18.752 -28.706 1.00 32.74 ? 186 PRO C CD  1 
ATOM   6116 N  N   . CYS C 1 182 ? -18.289 -15.361 -26.413 1.00 30.78 ? 187 CYS C N   1 
ATOM   6117 C  CA  . CYS C 1 182 ? -17.317 -14.296 -26.667 1.00 29.98 ? 187 CYS C CA  1 
ATOM   6118 C  C   . CYS C 1 182 ? -16.365 -13.985 -25.518 1.00 30.62 ? 187 CYS C C   1 
ATOM   6119 O  O   . CYS C 1 182 ? -15.559 -13.049 -25.616 1.00 31.10 ? 187 CYS C O   1 
ATOM   6120 C  CB  . CYS C 1 182 ? -18.053 -13.030 -27.089 1.00 29.80 ? 187 CYS C CB  1 
ATOM   6121 S  SG  . CYS C 1 182 ? -19.364 -12.542 -25.918 1.00 26.55 ? 187 CYS C SG  1 
ATOM   6122 N  N   . ILE C 1 183 ? -16.448 -14.743 -24.431 1.00 29.29 ? 188 ILE C N   1 
ATOM   6123 C  CA  . ILE C 1 183 ? -15.495 -14.581 -23.336 1.00 29.65 ? 188 ILE C CA  1 
ATOM   6124 C  C   . ILE C 1 183 ? -14.996 -15.934 -22.827 1.00 28.82 ? 188 ILE C C   1 
ATOM   6125 O  O   . ILE C 1 183 ? -15.715 -16.919 -22.879 1.00 27.94 ? 188 ILE C O   1 
ATOM   6126 C  CB  . ILE C 1 183 ? -16.056 -13.685 -22.173 1.00 30.86 ? 188 ILE C CB  1 
ATOM   6127 C  CG1 . ILE C 1 183 ? -17.278 -14.301 -21.521 1.00 31.55 ? 188 ILE C CG1 1 
ATOM   6128 C  CG2 . ILE C 1 183 ? -16.340 -12.199 -22.647 1.00 30.94 ? 188 ILE C CG2 1 
ATOM   6129 C  CD1 . ILE C 1 183 ? -17.532 -13.724 -20.134 1.00 35.45 ? 188 ILE C CD1 1 
ATOM   6130 N  N   . SER C 1 184 ? -13.738 -15.997 -22.409 1.00 28.51 ? 189 SER C N   1 
ATOM   6131 C  CA  . SER C 1 184 ? -13.216 -17.235 -21.873 1.00 28.76 ? 189 SER C CA  1 
ATOM   6132 C  C   . SER C 1 184 ? -13.308 -17.188 -20.348 1.00 27.89 ? 189 SER C C   1 
ATOM   6133 O  O   . SER C 1 184 ? -13.452 -16.117 -19.743 1.00 26.82 ? 189 SER C O   1 
ATOM   6134 C  CB  . SER C 1 184 ? -11.787 -17.492 -22.339 1.00 29.36 ? 189 SER C CB  1 
ATOM   6135 O  OG  . SER C 1 184 ? -10.933 -16.529 -21.766 1.00 33.57 ? 189 SER C OG  1 
ATOM   6136 N  N   . SER C 1 185 ? -13.208 -18.365 -19.745 1.00 26.89 ? 190 SER C N   1 
ATOM   6137 C  CA  . SER C 1 185 ? -13.363 -18.548 -18.299 1.00 25.49 ? 190 SER C CA  1 
ATOM   6138 C  C   . SER C 1 185 ? -12.331 -17.728 -17.499 1.00 24.37 ? 190 SER C C   1 
ATOM   6139 O  O   . SER C 1 185 ? -12.550 -17.389 -16.336 1.00 24.12 ? 190 SER C O   1 
ATOM   6140 C  CB  . SER C 1 185 ? -13.266 -20.055 -17.989 1.00 25.17 ? 190 SER C CB  1 
ATOM   6141 O  OG  . SER C 1 185 ? -11.925 -20.482 -18.125 1.00 27.60 ? 190 SER C OG  1 
ATOM   6142 N  N   . ALA C 1 186 ? -11.208 -17.396 -18.126 1.00 21.91 ? 191 ALA C N   1 
ATOM   6143 C  CA  . ALA C 1 186 ? -10.195 -16.584 -17.498 1.00 21.08 ? 191 ALA C CA  1 
ATOM   6144 C  C   . ALA C 1 186 ? -10.500 -15.075 -17.544 1.00 19.22 ? 191 ALA C C   1 
ATOM   6145 O  O   . ALA C 1 186 ? -9.785  -14.276 -16.948 1.00 18.90 ? 191 ALA C O   1 
ATOM   6146 C  CB  . ALA C 1 186 ? -8.758  -16.878 -18.126 1.00 21.88 ? 191 ALA C CB  1 
ATOM   6147 N  N   . SER C 1 187 ? -11.565 -14.689 -18.228 1.00 18.62 ? 192 SER C N   1 
ATOM   6148 C  CA  . SER C 1 187 ? -11.814 -13.267 -18.512 1.00 17.82 ? 192 SER C CA  1 
ATOM   6149 C  C   . SER C 1 187 ? -13.049 -12.676 -17.803 1.00 17.05 ? 192 SER C C   1 
ATOM   6150 O  O   . SER C 1 187 ? -13.450 -11.524 -18.068 1.00 14.71 ? 192 SER C O   1 
ATOM   6151 C  CB  . SER C 1 187 ? -11.856 -13.075 -20.029 1.00 18.50 ? 192 SER C CB  1 
ATOM   6152 O  OG  . SER C 1 187 ? -10.509 -13.209 -20.492 1.00 21.25 ? 192 SER C OG  1 
ATOM   6153 N  N   . ILE C 1 188 ? -13.623 -13.472 -16.892 1.00 16.00 ? 193 ILE C N   1 
ATOM   6154 C  CA  . ILE C 1 188 ? -14.732 -13.021 -16.031 1.00 14.80 ? 193 ILE C CA  1 
ATOM   6155 C  C   . ILE C 1 188 ? -14.375 -13.262 -14.545 1.00 14.69 ? 193 ILE C C   1 
ATOM   6156 O  O   . ILE C 1 188 ? -13.916 -14.358 -14.174 1.00 13.67 ? 193 ILE C O   1 
ATOM   6157 C  CB  . ILE C 1 188 ? -16.085 -13.680 -16.412 1.00 15.94 ? 193 ILE C CB  1 
ATOM   6158 C  CG1 . ILE C 1 188 ? -17.209 -13.200 -15.461 1.00 14.29 ? 193 ILE C CG1 1 
ATOM   6159 C  CG2 . ILE C 1 188 ? -15.969 -15.217 -16.456 1.00 15.42 ? 193 ILE C CG2 1 
ATOM   6160 C  CD1 . ILE C 1 188 ? -18.611 -13.557 -15.897 1.00 13.07 ? 193 ILE C CD1 1 
ATOM   6161 N  N   . VAL C 1 189 ? -14.535 -12.236 -13.712 1.00 13.67 ? 194 VAL C N   1 
ATOM   6162 C  CA  . VAL C 1 189 ? -14.355 -12.407 -12.264 1.00 12.98 ? 194 VAL C CA  1 
ATOM   6163 C  C   . VAL C 1 189 ? -15.679 -12.017 -11.593 1.00 13.11 ? 194 VAL C C   1 
ATOM   6164 O  O   . VAL C 1 189 ? -16.251 -10.965 -11.894 1.00 13.53 ? 194 VAL C O   1 
ATOM   6165 C  CB  . VAL C 1 189 ? -13.210 -11.545 -11.726 1.00 12.76 ? 194 VAL C CB  1 
ATOM   6166 C  CG1 . VAL C 1 189 ? -13.142 -11.582 -10.191 1.00 14.49 ? 194 VAL C CG1 1 
ATOM   6167 C  CG2 . VAL C 1 189 ? -11.884 -12.026 -12.310 1.00 13.90 ? 194 VAL C CG2 1 
ATOM   6168 N  N   . TYR C 1 190 ? -16.158 -12.867 -10.690 1.00 12.01 ? 195 TYR C N   1 
ATOM   6169 C  CA  . TYR C 1 190 ? -17.364 -12.574 -9.914  1.00 12.43 ? 195 TYR C CA  1 
ATOM   6170 C  C   . TYR C 1 190 ? -17.026 -11.974 -8.544  1.00 11.06 ? 195 TYR C C   1 
ATOM   6171 O  O   . TYR C 1 190 ? -16.052 -12.375 -7.907  1.00 10.91 ? 195 TYR C O   1 
ATOM   6172 C  CB  . TYR C 1 190 ? -18.081 -13.877 -9.628  1.00 12.37 ? 195 TYR C CB  1 
ATOM   6173 C  CG  . TYR C 1 190 ? -18.792 -14.463 -10.810 1.00 13.89 ? 195 TYR C CG  1 
ATOM   6174 C  CD1 . TYR C 1 190 ? -20.086 -14.053 -11.123 1.00 12.46 ? 195 TYR C CD1 1 
ATOM   6175 C  CD2 . TYR C 1 190 ? -18.193 -15.467 -11.575 1.00 13.16 ? 195 TYR C CD2 1 
ATOM   6176 C  CE1 . TYR C 1 190 ? -20.767 -14.626 -12.192 1.00 13.55 ? 195 TYR C CE1 1 
ATOM   6177 C  CE2 . TYR C 1 190 ? -18.844 -16.031 -12.650 1.00 14.20 ? 195 TYR C CE2 1 
ATOM   6178 C  CZ  . TYR C 1 190 ? -20.145 -15.621 -12.943 1.00 14.38 ? 195 TYR C CZ  1 
ATOM   6179 O  OH  . TYR C 1 190 ? -20.831 -16.202 -13.993 1.00 16.05 ? 195 TYR C OH  1 
ATOM   6180 N  N   . ILE C 1 191 ? -17.868 -11.061 -8.072  1.00 9.81  ? 196 ILE C N   1 
ATOM   6181 C  CA  . ILE C 1 191 ? -17.706 -10.456 -6.760  1.00 10.08 ? 196 ILE C CA  1 
ATOM   6182 C  C   . ILE C 1 191 ? -19.087 -10.398 -6.100  1.00 10.96 ? 196 ILE C C   1 
ATOM   6183 O  O   . ILE C 1 191 ? -20.010 -9.871  -6.710  1.00 10.21 ? 196 ILE C O   1 
ATOM   6184 C  CB  . ILE C 1 191 ? -17.151 -9.001  -6.849  1.00 10.62 ? 196 ILE C CB  1 
ATOM   6185 C  CG1 . ILE C 1 191 ? -15.729 -8.952  -7.480  1.00 10.05 ? 196 ILE C CG1 1 
ATOM   6186 C  CG2 . ILE C 1 191 ? -17.092 -8.398  -5.452  1.00 9.79  ? 196 ILE C CG2 1 
ATOM   6187 C  CD1 . ILE C 1 191 ? -15.237 -7.479  -7.730  1.00 11.12 ? 196 ILE C CD1 1 
ATOM   6188 N  N   . GLY C 1 192 ? -19.215 -10.952 -4.895  1.00 11.54 ? 197 GLY C N   1 
ATOM   6189 C  CA  . GLY C 1 192 ? -20.428 -10.792 -4.070  1.00 12.29 ? 197 GLY C CA  1 
ATOM   6190 C  C   . GLY C 1 192 ? -21.303 -12.023 -3.901  1.00 13.10 ? 197 GLY C C   1 
ATOM   6191 O  O   . GLY C 1 192 ? -22.361 -11.958 -3.264  1.00 13.32 ? 197 GLY C O   1 
ATOM   6192 N  N   . LEU C 1 193 ? -20.883 -13.132 -4.502  1.00 13.30 ? 198 LEU C N   1 
ATOM   6193 C  CA  . LEU C 1 193 ? -21.685 -14.362 -4.571  1.00 13.81 ? 198 LEU C CA  1 
ATOM   6194 C  C   . LEU C 1 193 ? -22.089 -14.824 -3.203  1.00 14.08 ? 198 LEU C C   1 
ATOM   6195 O  O   . LEU C 1 193 ? -21.287 -14.785 -2.265  1.00 14.06 ? 198 LEU C O   1 
ATOM   6196 C  CB  . LEU C 1 193 ? -20.907 -15.487 -5.280  1.00 13.85 ? 198 LEU C CB  1 
ATOM   6197 C  CG  . LEU C 1 193 ? -20.534 -15.223 -6.755  1.00 13.95 ? 198 LEU C CG  1 
ATOM   6198 C  CD1 . LEU C 1 193 ? -19.846 -16.462 -7.347  1.00 13.30 ? 198 LEU C CD1 1 
ATOM   6199 C  CD2 . LEU C 1 193 ? -21.721 -14.862 -7.641  1.00 13.29 ? 198 LEU C CD2 1 
ATOM   6200 N  N   . ARG C 1 194 ? -23.332 -15.300 -3.092  1.00 14.58 ? 199 ARG C N   1 
ATOM   6201 C  CA  . ARG C 1 194 ? -23.777 -15.896 -1.842  1.00 15.49 ? 199 ARG C CA  1 
ATOM   6202 C  C   . ARG C 1 194 ? -24.902 -16.896 -2.019  1.00 16.71 ? 199 ARG C C   1 
ATOM   6203 O  O   . ARG C 1 194 ? -25.189 -17.616 -1.082  1.00 17.67 ? 199 ARG C O   1 
ATOM   6204 C  CB  . ARG C 1 194 ? -24.197 -14.836 -0.810  1.00 14.82 ? 199 ARG C CB  1 
ATOM   6205 C  CG  . ARG C 1 194 ? -25.137 -13.751 -1.327  1.00 12.98 ? 199 ARG C CG  1 
ATOM   6206 C  CD  . ARG C 1 194 ? -25.207 -12.692 -0.228  1.00 14.74 ? 199 ARG C CD  1 
ATOM   6207 N  NE  . ARG C 1 194 ? -26.156 -11.625 -0.501  1.00 14.48 ? 199 ARG C NE  1 
ATOM   6208 C  CZ  . ARG C 1 194 ? -25.956 -10.590 -1.315  1.00 14.79 ? 199 ARG C CZ  1 
ATOM   6209 N  NH1 . ARG C 1 194 ? -24.811 -10.455 -1.995  1.00 13.91 ? 199 ARG C NH1 1 
ATOM   6210 N  NH2 . ARG C 1 194 ? -26.903 -9.657  -1.417  1.00 12.01 ? 199 ARG C NH2 1 
ATOM   6211 N  N   . ASP C 1 195 ? -25.490 -16.943 -3.215  1.00 17.64 ? 200 ASP C N   1 
ATOM   6212 C  CA  . ASP C 1 195 ? -26.571 -17.879 -3.560  1.00 18.74 ? 200 ASP C CA  1 
ATOM   6213 C  C   . ASP C 1 195 ? -26.248 -18.587 -4.868  1.00 17.95 ? 200 ASP C C   1 
ATOM   6214 O  O   . ASP C 1 195 ? -26.586 -18.093 -5.951  1.00 18.25 ? 200 ASP C O   1 
ATOM   6215 C  CB  . ASP C 1 195 ? -27.919 -17.169 -3.690  1.00 19.74 ? 200 ASP C CB  1 
ATOM   6216 C  CG  . ASP C 1 195 ? -29.080 -18.162 -3.927  1.00 22.97 ? 200 ASP C CG  1 
ATOM   6217 O  OD1 . ASP C 1 195 ? -28.890 -19.362 -3.648  1.00 26.71 ? 200 ASP C OD1 1 
ATOM   6218 O  OD2 . ASP C 1 195 ? -30.160 -17.744 -4.383  1.00 25.88 ? 200 ASP C OD2 1 
ATOM   6219 N  N   . VAL C 1 196 ? -25.558 -19.714 -4.754  1.00 17.80 ? 201 VAL C N   1 
ATOM   6220 C  CA  . VAL C 1 196 ? -24.966 -20.385 -5.901  1.00 18.73 ? 201 VAL C CA  1 
ATOM   6221 C  C   . VAL C 1 196 ? -25.545 -21.813 -5.888  1.00 19.64 ? 201 VAL C C   1 
ATOM   6222 O  O   . VAL C 1 196 ? -25.452 -22.507 -4.861  1.00 19.29 ? 201 VAL C O   1 
ATOM   6223 C  CB  . VAL C 1 196 ? -23.389 -20.403 -5.813  1.00 18.50 ? 201 VAL C CB  1 
ATOM   6224 C  CG1 . VAL C 1 196 ? -22.764 -21.083 -6.998  1.00 19.17 ? 201 VAL C CG1 1 
ATOM   6225 C  CG2 . VAL C 1 196 ? -22.826 -18.987 -5.694  1.00 18.31 ? 201 VAL C CG2 1 
ATOM   6226 N  N   . ASP C 1 197 ? -26.141 -22.226 -7.014  1.00 20.12 ? 202 ASP C N   1 
ATOM   6227 C  CA  . ASP C 1 197 ? -26.589 -23.625 -7.190  1.00 21.12 ? 202 ASP C CA  1 
ATOM   6228 C  C   . ASP C 1 197 ? -25.419 -24.604 -7.271  1.00 21.11 ? 202 ASP C C   1 
ATOM   6229 O  O   . ASP C 1 197 ? -24.321 -24.239 -7.747  1.00 20.78 ? 202 ASP C O   1 
ATOM   6230 C  CB  . ASP C 1 197 ? -27.477 -23.773 -8.427  1.00 21.76 ? 202 ASP C CB  1 
ATOM   6231 C  CG  . ASP C 1 197 ? -28.714 -22.918 -8.357  1.00 23.01 ? 202 ASP C CG  1 
ATOM   6232 O  OD1 . ASP C 1 197 ? -29.062 -22.489 -7.263  1.00 24.74 ? 202 ASP C OD1 1 
ATOM   6233 O  OD2 . ASP C 1 197 ? -29.339 -22.657 -9.388  1.00 25.50 ? 202 ASP C OD2 1 
ATOM   6234 N  N   . PRO C 1 198 ? -25.638 -25.867 -6.833  1.00 21.12 ? 203 PRO C N   1 
ATOM   6235 C  CA  . PRO C 1 198 ? -24.540 -26.842 -6.937  1.00 20.57 ? 203 PRO C CA  1 
ATOM   6236 C  C   . PRO C 1 198 ? -23.888 -26.924 -8.344  1.00 20.12 ? 203 PRO C C   1 
ATOM   6237 O  O   . PRO C 1 198 ? -22.648 -26.951 -8.421  1.00 20.17 ? 203 PRO C O   1 
ATOM   6238 C  CB  . PRO C 1 198 ? -25.190 -28.175 -6.505  1.00 21.42 ? 203 PRO C CB  1 
ATOM   6239 C  CG  . PRO C 1 198 ? -26.314 -27.738 -5.539  1.00 20.79 ? 203 PRO C CG  1 
ATOM   6240 C  CD  . PRO C 1 198 ? -26.820 -26.412 -6.113  1.00 21.18 ? 203 PRO C CD  1 
ATOM   6241 N  N   . PRO C 1 199 ? -24.687 -26.941 -9.432  1.00 20.01 ? 204 PRO C N   1 
ATOM   6242 C  CA  . PRO C 1 199 ? -24.065 -27.018 -10.773 1.00 19.62 ? 204 PRO C CA  1 
ATOM   6243 C  C   . PRO C 1 199 ? -23.226 -25.776 -11.076 1.00 19.99 ? 204 PRO C C   1 
ATOM   6244 O  O   . PRO C 1 199 ? -22.216 -25.860 -11.789 1.00 19.03 ? 204 PRO C O   1 
ATOM   6245 C  CB  . PRO C 1 199 ? -25.272 -27.085 -11.731 1.00 20.13 ? 204 PRO C CB  1 
ATOM   6246 C  CG  . PRO C 1 199 ? -26.456 -26.673 -10.949 1.00 20.81 ? 204 PRO C CG  1 
ATOM   6247 C  CD  . PRO C 1 199 ? -26.168 -27.006 -9.523  1.00 20.39 ? 204 PRO C CD  1 
ATOM   6248 N  N   . GLU C 1 200 ? -23.648 -24.633 -10.537 1.00 19.41 ? 205 GLU C N   1 
ATOM   6249 C  CA  . GLU C 1 200 ? -22.915 -23.383 -10.772 1.00 18.77 ? 205 GLU C CA  1 
ATOM   6250 C  C   . GLU C 1 200 ? -21.588 -23.449 -10.032 1.00 18.84 ? 205 GLU C C   1 
ATOM   6251 O  O   . GLU C 1 200 ? -20.553 -23.057 -10.569 1.00 18.63 ? 205 GLU C O   1 
ATOM   6252 C  CB  . GLU C 1 200 ? -23.721 -22.184 -10.299 1.00 18.32 ? 205 GLU C CB  1 
ATOM   6253 C  CG  . GLU C 1 200 ? -24.988 -21.910 -11.121 1.00 18.06 ? 205 GLU C CG  1 
ATOM   6254 C  CD  . GLU C 1 200 ? -25.682 -20.652 -10.697 1.00 20.36 ? 205 GLU C CD  1 
ATOM   6255 O  OE1 . GLU C 1 200 ? -26.153 -20.601 -9.532  1.00 20.17 ? 205 GLU C OE1 1 
ATOM   6256 O  OE2 . GLU C 1 200 ? -25.771 -19.710 -11.527 1.00 19.60 ? 205 GLU C OE2 1 
ATOM   6257 N  N   . HIS C 1 201 ? -21.624 -23.941 -8.795  1.00 17.88 ? 206 HIS C N   1 
ATOM   6258 C  CA  . HIS C 1 201 ? -20.391 -24.181 -8.057  1.00 19.06 ? 206 HIS C CA  1 
ATOM   6259 C  C   . HIS C 1 201 ? -19.452 -25.089 -8.854  1.00 19.37 ? 206 HIS C C   1 
ATOM   6260 O  O   . HIS C 1 201 ? -18.260 -24.832 -8.924  1.00 17.93 ? 206 HIS C O   1 
ATOM   6261 C  CB  . HIS C 1 201 ? -20.685 -24.814 -6.697  1.00 19.01 ? 206 HIS C CB  1 
ATOM   6262 C  CG  . HIS C 1 201 ? -19.462 -25.030 -5.857  1.00 23.80 ? 206 HIS C CG  1 
ATOM   6263 N  ND1 . HIS C 1 201 ? -18.851 -26.259 -5.733  1.00 24.50 ? 206 HIS C ND1 1 
ATOM   6264 C  CD2 . HIS C 1 201 ? -18.719 -24.165 -5.119  1.00 23.70 ? 206 HIS C CD2 1 
ATOM   6265 C  CE1 . HIS C 1 201 ? -17.804 -26.152 -4.932  1.00 25.22 ? 206 HIS C CE1 1 
ATOM   6266 N  NE2 . HIS C 1 201 ? -17.701 -24.893 -4.545  1.00 24.21 ? 206 HIS C NE2 1 
ATOM   6267 N  N   . PHE C 1 202 ? -19.997 -26.183 -9.393  1.00 19.62 ? 207 PHE C N   1 
ATOM   6268 C  CA  . PHE C 1 202 ? -19.183 -27.105 -10.173 1.00 19.82 ? 207 PHE C CA  1 
ATOM   6269 C  C   . PHE C 1 202 ? -18.594 -26.366 -11.377 1.00 20.32 ? 207 PHE C C   1 
ATOM   6270 O  O   . PHE C 1 202 ? -17.413 -26.502 -11.677 1.00 21.10 ? 207 PHE C O   1 
ATOM   6271 C  CB  . PHE C 1 202 ? -20.005 -28.272 -10.676 1.00 20.27 ? 207 PHE C CB  1 
ATOM   6272 C  CG  . PHE C 1 202 ? -19.216 -29.210 -11.531 1.00 22.11 ? 207 PHE C CG  1 
ATOM   6273 C  CD1 . PHE C 1 202 ? -18.247 -30.025 -10.946 1.00 25.17 ? 207 PHE C CD1 1 
ATOM   6274 C  CD2 . PHE C 1 202 ? -19.404 -29.256 -12.920 1.00 24.66 ? 207 PHE C CD2 1 
ATOM   6275 C  CE1 . PHE C 1 202 ? -17.483 -30.882 -11.724 1.00 26.77 ? 207 PHE C CE1 1 
ATOM   6276 C  CE2 . PHE C 1 202 ? -18.649 -30.117 -13.703 1.00 26.18 ? 207 PHE C CE2 1 
ATOM   6277 C  CZ  . PHE C 1 202 ? -17.683 -30.934 -13.092 1.00 26.07 ? 207 PHE C CZ  1 
ATOM   6278 N  N   . ILE C 1 203 ? -19.420 -25.578 -12.055 1.00 19.74 ? 208 ILE C N   1 
ATOM   6279 C  CA  . ILE C 1 203 ? -18.912 -24.829 -13.223 1.00 20.78 ? 208 ILE C CA  1 
ATOM   6280 C  C   . ILE C 1 203 ? -17.751 -23.892 -12.864 1.00 19.91 ? 208 ILE C C   1 
ATOM   6281 O  O   . ILE C 1 203 ? -16.717 -23.865 -13.541 1.00 20.93 ? 208 ILE C O   1 
ATOM   6282 C  CB  . ILE C 1 203 ? -20.033 -24.088 -13.938 1.00 19.82 ? 208 ILE C CB  1 
ATOM   6283 C  CG1 . ILE C 1 203 ? -20.903 -25.094 -14.682 1.00 20.29 ? 208 ILE C CG1 1 
ATOM   6284 C  CG2 . ILE C 1 203 ? -19.430 -23.088 -14.970 1.00 20.75 ? 208 ILE C CG2 1 
ATOM   6285 C  CD1 . ILE C 1 203 ? -22.279 -24.605 -15.002 1.00 19.02 ? 208 ILE C CD1 1 
ATOM   6286 N  N   . LEU C 1 204 ? -17.908 -23.156 -11.769 1.00 19.09 ? 209 LEU C N   1 
ATOM   6287 C  CA  . LEU C 1 204 ? -16.896 -22.176 -11.360 1.00 20.08 ? 209 LEU C CA  1 
ATOM   6288 C  C   . LEU C 1 204 ? -15.597 -22.897 -11.047 1.00 19.91 ? 209 LEU C C   1 
ATOM   6289 O  O   . LEU C 1 204 ? -14.510 -22.502 -11.498 1.00 20.16 ? 209 LEU C O   1 
ATOM   6290 C  CB  . LEU C 1 204 ? -17.382 -21.350 -10.128 1.00 18.37 ? 209 LEU C CB  1 
ATOM   6291 C  CG  . LEU C 1 204 ? -18.642 -20.507 -10.406 1.00 19.42 ? 209 LEU C CG  1 
ATOM   6292 C  CD1 . LEU C 1 204 ? -19.295 -20.022 -9.078  1.00 16.04 ? 209 LEU C CD1 1 
ATOM   6293 C  CD2 . LEU C 1 204 ? -18.331 -19.324 -11.262 1.00 20.00 ? 209 LEU C CD2 1 
ATOM   6294 N  N   . LYS C 1 205 ? -15.699 -23.953 -10.257 1.00 21.07 ? 210 LYS C N   1 
ATOM   6295 C  CA  . LYS C 1 205 ? -14.494 -24.652 -9.826  1.00 21.61 ? 210 LYS C CA  1 
ATOM   6296 C  C   . LYS C 1 205 ? -13.864 -25.373 -10.996 1.00 22.08 ? 210 LYS C C   1 
ATOM   6297 O  O   . LYS C 1 205 ? -12.660 -25.261 -11.219 1.00 21.66 ? 210 LYS C O   1 
ATOM   6298 C  CB  . LYS C 1 205 ? -14.795 -25.665 -8.714  1.00 22.26 ? 210 LYS C CB  1 
ATOM   6299 C  CG  . LYS C 1 205 ? -15.218 -25.049 -7.383  1.00 24.76 ? 210 LYS C CG  1 
ATOM   6300 C  CD  . LYS C 1 205 ? -14.064 -24.203 -6.774  1.00 25.86 ? 210 LYS C CD  1 
ATOM   6301 C  CE  . LYS C 1 205 ? -14.344 -23.837 -5.328  1.00 27.70 ? 210 LYS C CE  1 
ATOM   6302 N  NZ  . LYS C 1 205 ? -13.186 -23.114 -4.743  1.00 28.25 ? 210 LYS C NZ  1 
ATOM   6303 N  N   . ASN C 1 206 ? -14.680 -26.099 -11.747 1.00 23.00 ? 211 ASN C N   1 
ATOM   6304 C  CA  . ASN C 1 206 ? -14.132 -26.965 -12.786 1.00 23.44 ? 211 ASN C CA  1 
ATOM   6305 C  C   . ASN C 1 206 ? -13.421 -26.178 -13.876 1.00 23.72 ? 211 ASN C C   1 
ATOM   6306 O  O   . ASN C 1 206 ? -12.336 -26.579 -14.326 1.00 23.49 ? 211 ASN C O   1 
ATOM   6307 C  CB  . ASN C 1 206 ? -15.211 -27.819 -13.409 1.00 23.72 ? 211 ASN C CB  1 
ATOM   6308 C  CG  . ASN C 1 206 ? -14.633 -28.904 -14.294 1.00 25.42 ? 211 ASN C CG  1 
ATOM   6309 O  OD1 . ASN C 1 206 ? -13.890 -29.778 -13.823 1.00 24.71 ? 211 ASN C OD1 1 
ATOM   6310 N  ND2 . ASN C 1 206 ? -14.959 -28.853 -15.578 1.00 24.87 ? 211 ASN C ND2 1 
ATOM   6311 N  N   . TYR C 1 207 ? -14.013 -25.048 -14.263 1.00 22.64 ? 212 TYR C N   1 
ATOM   6312 C  CA  . TYR C 1 207 ? -13.448 -24.203 -15.315 1.00 23.13 ? 212 TYR C CA  1 
ATOM   6313 C  C   . TYR C 1 207 ? -12.522 -23.088 -14.871 1.00 22.72 ? 212 TYR C C   1 
ATOM   6314 O  O   . TYR C 1 207 ? -12.181 -22.240 -15.688 1.00 21.76 ? 212 TYR C O   1 
ATOM   6315 C  CB  . TYR C 1 207 ? -14.574 -23.650 -16.183 1.00 22.95 ? 212 TYR C CB  1 
ATOM   6316 C  CG  . TYR C 1 207 ? -15.226 -24.769 -16.906 1.00 25.31 ? 212 TYR C CG  1 
ATOM   6317 C  CD1 . TYR C 1 207 ? -16.383 -25.360 -16.399 1.00 26.14 ? 212 TYR C CD1 1 
ATOM   6318 C  CD2 . TYR C 1 207 ? -14.657 -25.297 -18.077 1.00 26.46 ? 212 TYR C CD2 1 
ATOM   6319 C  CE1 . TYR C 1 207 ? -16.977 -26.424 -17.043 1.00 27.89 ? 212 TYR C CE1 1 
ATOM   6320 C  CE2 . TYR C 1 207 ? -15.255 -26.382 -18.739 1.00 27.39 ? 212 TYR C CE2 1 
ATOM   6321 C  CZ  . TYR C 1 207 ? -16.409 -26.938 -18.204 1.00 28.23 ? 212 TYR C CZ  1 
ATOM   6322 O  OH  . TYR C 1 207 ? -17.030 -27.990 -18.828 1.00 27.29 ? 212 TYR C OH  1 
ATOM   6323 N  N   . ASP C 1 208 ? -12.098 -23.115 -13.600 1.00 22.07 ? 213 ASP C N   1 
ATOM   6324 C  CA  . ASP C 1 208 ? -11.159 -22.155 -13.061 1.00 22.08 ? 213 ASP C CA  1 
ATOM   6325 C  C   . ASP C 1 208 ? -11.650 -20.717 -13.203 1.00 20.93 ? 213 ASP C C   1 
ATOM   6326 O  O   . ASP C 1 208 ? -10.860 -19.818 -13.505 1.00 20.28 ? 213 ASP C O   1 
ATOM   6327 C  CB  . ASP C 1 208 ? -9.768  -22.319 -13.709 1.00 23.65 ? 213 ASP C CB  1 
ATOM   6328 C  CG  . ASP C 1 208 ? -9.172  -23.717 -13.479 1.00 27.16 ? 213 ASP C CG  1 
ATOM   6329 O  OD1 . ASP C 1 208 ? -9.112  -24.167 -12.305 1.00 28.81 ? 213 ASP C OD1 1 
ATOM   6330 O  OD2 . ASP C 1 208 ? -8.729  -24.348 -14.472 1.00 29.54 ? 213 ASP C OD2 1 
ATOM   6331 N  N   . ILE C 1 209 ? -12.943 -20.509 -12.998 1.00 19.32 ? 214 ILE C N   1 
ATOM   6332 C  CA  . ILE C 1 209 ? -13.513 -19.147 -12.996 1.00 18.65 ? 214 ILE C CA  1 
ATOM   6333 C  C   . ILE C 1 209 ? -13.307 -18.552 -11.603 1.00 18.48 ? 214 ILE C C   1 
ATOM   6334 O  O   . ILE C 1 209 ? -13.751 -19.114 -10.594 1.00 17.10 ? 214 ILE C O   1 
ATOM   6335 C  CB  . ILE C 1 209 ? -14.988 -19.143 -13.386 1.00 18.91 ? 214 ILE C CB  1 
ATOM   6336 C  CG1 . ILE C 1 209 ? -15.144 -19.732 -14.785 1.00 18.13 ? 214 ILE C CG1 1 
ATOM   6337 C  CG2 . ILE C 1 209 ? -15.590 -17.707 -13.311 1.00 17.97 ? 214 ILE C CG2 1 
ATOM   6338 C  CD1 . ILE C 1 209 ? -16.548 -20.130 -15.093 1.00 18.29 ? 214 ILE C CD1 1 
ATOM   6339 N  N   . GLN C 1 210 ? -12.609 -17.428 -11.561 1.00 17.20 ? 215 GLN C N   1 
ATOM   6340 C  CA  . GLN C 1 210 ? -12.245 -16.838 -10.292 1.00 17.42 ? 215 GLN C CA  1 
ATOM   6341 C  C   . GLN C 1 210 ? -13.425 -16.024 -9.746  1.00 16.38 ? 215 GLN C C   1 
ATOM   6342 O  O   . GLN C 1 210 ? -14.102 -15.322 -10.479 1.00 14.99 ? 215 GLN C O   1 
ATOM   6343 C  CB  . GLN C 1 210 ? -10.994 -16.004 -10.441 1.00 18.55 ? 215 GLN C CB  1 
ATOM   6344 C  CG  . GLN C 1 210 ? -9.786  -16.825 -11.044 1.00 21.01 ? 215 GLN C CG  1 
ATOM   6345 C  CD  . GLN C 1 210 ? -9.449  -18.053 -10.213 1.00 25.91 ? 215 GLN C CD  1 
ATOM   6346 O  OE1 . GLN C 1 210 ? -9.134  -17.935 -9.035  1.00 27.48 ? 215 GLN C OE1 1 
ATOM   6347 N  NE2 . GLN C 1 210 ? -9.553  -19.235 -10.815 1.00 26.01 ? 215 GLN C NE2 1 
ATOM   6348 N  N   . TYR C 1 211 ? -13.695 -16.198 -8.459  1.00 15.95 ? 216 TYR C N   1 
ATOM   6349 C  CA  . TYR C 1 211 ? -14.821 -15.511 -7.823  1.00 15.36 ? 216 TYR C CA  1 
ATOM   6350 C  C   . TYR C 1 211 ? -14.479 -15.148 -6.381  1.00 14.80 ? 216 TYR C C   1 
ATOM   6351 O  O   . TYR C 1 211 ? -13.694 -15.849 -5.731  1.00 13.76 ? 216 TYR C O   1 
ATOM   6352 C  CB  . TYR C 1 211 ? -16.085 -16.352 -7.874  1.00 15.56 ? 216 TYR C CB  1 
ATOM   6353 C  CG  . TYR C 1 211 ? -16.058 -17.647 -7.075  1.00 17.17 ? 216 TYR C CG  1 
ATOM   6354 C  CD1 . TYR C 1 211 ? -16.488 -17.678 -5.729  1.00 17.43 ? 216 TYR C CD1 1 
ATOM   6355 C  CD2 . TYR C 1 211 ? -15.714 -18.850 -7.692  1.00 17.63 ? 216 TYR C CD2 1 
ATOM   6356 C  CE1 . TYR C 1 211 ? -16.509 -18.881 -5.007  1.00 20.54 ? 216 TYR C CE1 1 
ATOM   6357 C  CE2 . TYR C 1 211 ? -15.722 -20.042 -6.990  1.00 17.55 ? 216 TYR C CE2 1 
ATOM   6358 C  CZ  . TYR C 1 211 ? -16.137 -20.052 -5.648  1.00 20.09 ? 216 TYR C CZ  1 
ATOM   6359 O  OH  . TYR C 1 211 ? -16.165 -21.249 -4.958  1.00 24.40 ? 216 TYR C OH  1 
ATOM   6360 N  N   . PHE C 1 212 ? -14.995 -14.012 -5.920  1.00 12.86 ? 217 PHE C N   1 
ATOM   6361 C  CA  . PHE C 1 212 ? -14.842 -13.612 -4.529  1.00 13.11 ? 217 PHE C CA  1 
ATOM   6362 C  C   . PHE C 1 212 ? -16.224 -13.558 -3.934  1.00 12.27 ? 217 PHE C C   1 
ATOM   6363 O  O   . PHE C 1 212 ? -16.951 -12.601 -4.172  1.00 12.68 ? 217 PHE C O   1 
ATOM   6364 C  CB  . PHE C 1 212 ? -14.143 -12.259 -4.449  1.00 12.75 ? 217 PHE C CB  1 
ATOM   6365 C  CG  . PHE C 1 212 ? -12.777 -12.274 -5.052  1.00 15.84 ? 217 PHE C CG  1 
ATOM   6366 C  CD1 . PHE C 1 212 ? -12.587 -11.948 -6.401  1.00 15.23 ? 217 PHE C CD1 1 
ATOM   6367 C  CD2 . PHE C 1 212 ? -11.671 -12.665 -4.278  1.00 18.11 ? 217 PHE C CD2 1 
ATOM   6368 C  CE1 . PHE C 1 212 ? -11.304 -11.992 -6.961  1.00 15.94 ? 217 PHE C CE1 1 
ATOM   6369 C  CE2 . PHE C 1 212 ? -10.377 -12.700 -4.840  1.00 18.55 ? 217 PHE C CE2 1 
ATOM   6370 C  CZ  . PHE C 1 212 ? -10.211 -12.375 -6.181  1.00 18.41 ? 217 PHE C CZ  1 
ATOM   6371 N  N   . SER C 1 213 ? -16.612 -14.620 -3.226  1.00 12.91 ? 218 SER C N   1 
ATOM   6372 C  CA  . SER C 1 213 ? -17.958 -14.679 -2.605  1.00 13.47 ? 218 SER C CA  1 
ATOM   6373 C  C   . SER C 1 213 ? -17.955 -13.720 -1.403  1.00 13.93 ? 218 SER C C   1 
ATOM   6374 O  O   . SER C 1 213 ? -16.925 -13.209 -1.035  1.00 13.35 ? 218 SER C O   1 
ATOM   6375 C  CB  . SER C 1 213 ? -18.265 -16.089 -2.116  1.00 13.23 ? 218 SER C CB  1 
ATOM   6376 O  OG  . SER C 1 213 ? -17.383 -16.402 -1.041  1.00 15.64 ? 218 SER C OG  1 
ATOM   6377 N  N   . MET C 1 214 ? -19.125 -13.488 -0.810  1.00 14.59 ? 219 MET C N   1 
ATOM   6378 C  CA  . MET C 1 214 ? -19.190 -12.750 0.445   1.00 13.49 ? 219 MET C CA  1 
ATOM   6379 C  C   . MET C 1 214 ? -18.205 -13.318 1.466   1.00 13.86 ? 219 MET C C   1 
ATOM   6380 O  O   . MET C 1 214 ? -17.598 -12.568 2.210   1.00 14.27 ? 219 MET C O   1 
ATOM   6381 C  CB  . MET C 1 214 ? -20.628 -12.768 0.980   1.00 12.98 ? 219 MET C CB  1 
ATOM   6382 C  CG  . MET C 1 214 ? -21.598 -12.036 0.068   1.00 13.28 ? 219 MET C CG  1 
ATOM   6383 S  SD  . MET C 1 214 ? -21.164 -10.381 -0.514  1.00 15.44 ? 219 MET C SD  1 
ATOM   6384 C  CE  . MET C 1 214 ? -20.775 -9.481  0.992   1.00 12.86 ? 219 MET C CE  1 
ATOM   6385 N  N   . ARG C 1 215 ? -17.996 -14.639 1.460   1.00 13.07 ? 220 ARG C N   1 
ATOM   6386 C  CA  . ARG C 1 215 ? -17.055 -15.246 2.391   1.00 13.40 ? 220 ARG C CA  1 
ATOM   6387 C  C   . ARG C 1 215 ? -15.604 -14.792 2.082   1.00 12.83 ? 220 ARG C C   1 
ATOM   6388 O  O   . ARG C 1 215 ? -14.839 -14.468 2.995   1.00 11.33 ? 220 ARG C O   1 
ATOM   6389 C  CB  . ARG C 1 215 ? -17.189 -16.787 2.362   1.00 13.86 ? 220 ARG C CB  1 
ATOM   6390 C  CG  . ARG C 1 215 ? -16.195 -17.540 3.243   1.00 16.87 ? 220 ARG C CG  1 
ATOM   6391 C  CD  . ARG C 1 215 ? -16.304 -19.082 3.075   1.00 20.36 ? 220 ARG C CD  1 
ATOM   6392 N  NE  . ARG C 1 215 ? -15.062 -19.686 3.546   1.00 24.47 ? 220 ARG C NE  1 
ATOM   6393 C  CZ  . ARG C 1 215 ? -14.815 -20.002 4.812   1.00 26.44 ? 220 ARG C CZ  1 
ATOM   6394 N  NH1 . ARG C 1 215 ? -15.762 -19.805 5.740   1.00 26.03 ? 220 ARG C NH1 1 
ATOM   6395 N  NH2 . ARG C 1 215 ? -13.625 -20.504 5.144   1.00 24.82 ? 220 ARG C NH2 1 
ATOM   6396 N  N   . ASP C 1 216 ? -15.250 -14.744 0.801   1.00 11.25 ? 221 ASP C N   1 
ATOM   6397 C  CA  . ASP C 1 216 ? -13.933 -14.237 0.435   1.00 12.51 ? 221 ASP C CA  1 
ATOM   6398 C  C   . ASP C 1 216 ? -13.752 -12.783 0.855   1.00 11.70 ? 221 ASP C C   1 
ATOM   6399 O  O   . ASP C 1 216 ? -12.685 -12.380 1.286   1.00 10.67 ? 221 ASP C O   1 
ATOM   6400 C  CB  . ASP C 1 216 ? -13.685 -14.419 -1.068  1.00 12.25 ? 221 ASP C CB  1 
ATOM   6401 C  CG  . ASP C 1 216 ? -13.589 -15.882 -1.447  1.00 15.68 ? 221 ASP C CG  1 
ATOM   6402 O  OD1 . ASP C 1 216 ? -12.765 -16.624 -0.833  1.00 16.42 ? 221 ASP C OD1 1 
ATOM   6403 O  OD2 . ASP C 1 216 ? -14.363 -16.302 -2.312  1.00 14.77 ? 221 ASP C OD2 1 
ATOM   6404 N  N   . ILE C 1 217 ? -14.804 -11.991 0.713   1.00 10.56 ? 222 ILE C N   1 
ATOM   6405 C  CA  . ILE C 1 217 ? -14.733 -10.588 1.132   1.00 11.56 ? 222 ILE C CA  1 
ATOM   6406 C  C   . ILE C 1 217 ? -14.593 -10.470 2.670   1.00 11.43 ? 222 ILE C C   1 
ATOM   6407 O  O   . ILE C 1 217 ? -13.816 -9.629  3.173   1.00 11.62 ? 222 ILE C O   1 
ATOM   6408 C  CB  . ILE C 1 217 ? -15.940 -9.785  0.617   1.00 11.09 ? 222 ILE C CB  1 
ATOM   6409 C  CG1 . ILE C 1 217 ? -16.035 -9.863  -0.913  1.00 12.21 ? 222 ILE C CG1 1 
ATOM   6410 C  CG2 . ILE C 1 217 ? -15.857 -8.307  1.101   1.00 11.05 ? 222 ILE C CG2 1 
ATOM   6411 C  CD1 . ILE C 1 217 ? -17.349 -9.225  -1.499  1.00 10.74 ? 222 ILE C CD1 1 
ATOM   6412 N  N   . ASP C 1 218 ? -15.314 -11.317 3.407   1.00 11.77 ? 223 ASP C N   1 
ATOM   6413 C  CA  . ASP C 1 218 ? -15.207 -11.349 4.882   1.00 12.61 ? 223 ASP C CA  1 
ATOM   6414 C  C   . ASP C 1 218 ? -13.748 -11.571 5.302   1.00 13.58 ? 223 ASP C C   1 
ATOM   6415 O  O   . ASP C 1 218 ? -13.274 -10.985 6.309   1.00 14.06 ? 223 ASP C O   1 
ATOM   6416 C  CB  . ASP C 1 218 ? -16.085 -12.463 5.495   1.00 11.84 ? 223 ASP C CB  1 
ATOM   6417 C  CG  . ASP C 1 218 ? -17.573 -12.206 5.301   1.00 13.72 ? 223 ASP C CG  1 
ATOM   6418 O  OD1 . ASP C 1 218 ? -17.977 -11.023 5.178   1.00 13.48 ? 223 ASP C OD1 1 
ATOM   6419 O  OD2 . ASP C 1 218 ? -18.342 -13.191 5.288   1.00 13.49 ? 223 ASP C OD2 1 
ATOM   6420 N  N   . ARG C 1 219 ? -13.074 -12.463 4.573   1.00 13.58 ? 224 ARG C N   1 
ATOM   6421 C  CA  . ARG C 1 219 ? -11.668 -12.822 4.844   1.00 14.37 ? 224 ARG C CA  1 
ATOM   6422 C  C   . ARG C 1 219 ? -10.651 -11.818 4.366   1.00 14.65 ? 224 ARG C C   1 
ATOM   6423 O  O   . ARG C 1 219 ? -9.721  -11.472 5.113   1.00 15.05 ? 224 ARG C O   1 
ATOM   6424 C  CB  . ARG C 1 219 ? -11.342 -14.178 4.216   1.00 15.52 ? 224 ARG C CB  1 
ATOM   6425 C  CG  . ARG C 1 219 ? -12.135 -15.350 4.796   1.00 16.74 ? 224 ARG C CG  1 
ATOM   6426 C  CD  . ARG C 1 219 ? -12.063 -16.644 3.921   1.00 21.88 ? 224 ARG C CD  1 
ATOM   6427 N  NE  . ARG C 1 219 ? -10.670 -17.061 3.653   1.00 25.24 ? 224 ARG C NE  1 
ATOM   6428 C  CZ  . ARG C 1 219 ? -9.924  -17.794 4.490   1.00 30.22 ? 224 ARG C CZ  1 
ATOM   6429 N  NH1 . ARG C 1 219 ? -10.421 -18.212 5.661   1.00 29.88 ? 224 ARG C NH1 1 
ATOM   6430 N  NH2 . ARG C 1 219 ? -8.658  -18.104 4.166   1.00 30.17 ? 224 ARG C NH2 1 
ATOM   6431 N  N   . LEU C 1 220 ? -10.781 -11.357 3.119   1.00 14.34 ? 225 LEU C N   1 
ATOM   6432 C  CA  . LEU C 1 220 ? -9.707  -10.538 2.529   1.00 14.28 ? 225 LEU C CA  1 
ATOM   6433 C  C   . LEU C 1 220 ? -9.984  -9.068  2.716   1.00 14.43 ? 225 LEU C C   1 
ATOM   6434 O  O   . LEU C 1 220 ? -9.073  -8.283  2.811   1.00 14.32 ? 225 LEU C O   1 
ATOM   6435 C  CB  . LEU C 1 220 ? -9.603  -10.801 1.032   1.00 14.61 ? 225 LEU C CB  1 
ATOM   6436 C  CG  . LEU C 1 220 ? -9.180  -12.178 0.541   1.00 16.89 ? 225 LEU C CG  1 
ATOM   6437 C  CD1 . LEU C 1 220 ? -9.526  -12.336 -0.947  1.00 18.43 ? 225 LEU C CD1 1 
ATOM   6438 C  CD2 . LEU C 1 220 ? -7.688  -12.355 0.788   1.00 18.42 ? 225 LEU C CD2 1 
ATOM   6439 N  N   . GLY C 1 221 ? -11.264 -8.698  2.750   1.00 13.14 ? 226 GLY C N   1 
ATOM   6440 C  CA  . GLY C 1 221 ? -11.609 -7.302  2.665   1.00 14.48 ? 226 GLY C CA  1 
ATOM   6441 C  C   . GLY C 1 221 ? -11.695 -6.829  1.219   1.00 14.01 ? 226 GLY C C   1 
ATOM   6442 O  O   . GLY C 1 221 ? -10.950 -7.300  0.345   1.00 14.16 ? 226 GLY C O   1 
ATOM   6443 N  N   . ILE C 1 222 ? -12.618 -5.901  0.966   1.00 13.46 ? 227 ILE C N   1 
ATOM   6444 C  CA  . ILE C 1 222 ? -12.863 -5.394  -0.374  1.00 13.45 ? 227 ILE C CA  1 
ATOM   6445 C  C   . ILE C 1 222 ? -11.624 -4.774  -1.123  1.00 13.45 ? 227 ILE C C   1 
ATOM   6446 O  O   . ILE C 1 222 ? -11.565 -4.843  -2.345  1.00 14.30 ? 227 ILE C O   1 
ATOM   6447 C  CB  . ILE C 1 222 ? -14.120 -4.468  -0.403  1.00 12.57 ? 227 ILE C CB  1 
ATOM   6448 C  CG1 . ILE C 1 222 ? -14.700 -4.376  -1.815  1.00 14.65 ? 227 ILE C CG1 1 
ATOM   6449 C  CG2 . ILE C 1 222 ? -13.814 -3.065  0.170   1.00 13.26 ? 227 ILE C CG2 1 
ATOM   6450 C  CD1 . ILE C 1 222 ? -15.363 -5.705  -2.324  1.00 16.95 ? 227 ILE C CD1 1 
ATOM   6451 N  N   . GLN C 1 223 ? -10.666 -4.191  -0.412  1.00 14.31 ? 228 GLN C N   1 
ATOM   6452 C  CA  . GLN C 1 223 ? -9.458  -3.646  -1.062  1.00 14.81 ? 228 GLN C CA  1 
ATOM   6453 C  C   . GLN C 1 223 ? -8.661  -4.750  -1.779  1.00 14.37 ? 228 GLN C C   1 
ATOM   6454 O  O   . GLN C 1 223 ? -8.397  -4.624  -2.981  1.00 13.43 ? 228 GLN C O   1 
ATOM   6455 C  CB  . GLN C 1 223 ? -8.523  -2.845  -0.124  1.00 15.92 ? 228 GLN C CB  1 
ATOM   6456 C  CG  . GLN C 1 223 ? -7.097  -2.632  -0.759  1.00 20.07 ? 228 GLN C CG  1 
ATOM   6457 C  CD  . GLN C 1 223 ? -6.044  -2.097  0.200   1.00 26.93 ? 228 GLN C CD  1 
ATOM   6458 O  OE1 . GLN C 1 223 ? -4.856  -2.012  -0.157  1.00 32.64 ? 228 GLN C OE1 1 
ATOM   6459 N  NE2 . GLN C 1 223 ? -6.450  -1.730  1.411   1.00 23.96 ? 228 GLN C NE2 1 
ATOM   6460 N  N   . LYS C 1 224 ? -8.354  -5.835  -1.052  1.00 14.52 ? 229 LYS C N   1 
ATOM   6461 C  CA  . LYS C 1 224 ? -7.633  -6.998  -1.607  1.00 14.73 ? 229 LYS C CA  1 
ATOM   6462 C  C   . LYS C 1 224 ? -8.437  -7.702  -2.675  1.00 14.05 ? 229 LYS C C   1 
ATOM   6463 O  O   . LYS C 1 224 ? -7.901  -8.137  -3.653  1.00 13.56 ? 229 LYS C O   1 
ATOM   6464 C  CB  . LYS C 1 224 ? -7.220  -7.989  -0.504  1.00 15.05 ? 229 LYS C CB  1 
ATOM   6465 C  CG  . LYS C 1 224 ? -6.119  -7.441  0.445   1.00 21.19 ? 229 LYS C CG  1 
ATOM   6466 C  CD  . LYS C 1 224 ? -5.670  -8.468  1.517   1.00 28.58 ? 229 LYS C CD  1 
ATOM   6467 C  CE  . LYS C 1 224 ? -5.012  -9.718  0.878   1.00 34.63 ? 229 LYS C CE  1 
ATOM   6468 N  NZ  . LYS C 1 224 ? -4.345  -10.678 1.868   1.00 38.40 ? 229 LYS C NZ  1 
ATOM   6469 N  N   . VAL C 1 225 ? -9.756  -7.753  -2.505  1.00 13.45 ? 230 VAL C N   1 
ATOM   6470 C  CA  . VAL C 1 225 ? -10.629 -8.313  -3.529  1.00 13.02 ? 230 VAL C CA  1 
ATOM   6471 C  C   . VAL C 1 225 ? -10.498 -7.579  -4.856  1.00 13.61 ? 230 VAL C C   1 
ATOM   6472 O  O   . VAL C 1 225 ? -10.299 -8.213  -5.889  1.00 13.97 ? 230 VAL C O   1 
ATOM   6473 C  CB  . VAL C 1 225 ? -12.083 -8.470  -2.999  1.00 12.44 ? 230 VAL C CB  1 
ATOM   6474 C  CG1 . VAL C 1 225 ? -13.114 -8.625  -4.163  1.00 14.95 ? 230 VAL C CG1 1 
ATOM   6475 C  CG2 . VAL C 1 225 ? -12.100 -9.700  -2.100  1.00 11.75 ? 230 VAL C CG2 1 
ATOM   6476 N  N   . MET C 1 226 ? -10.495 -6.247  -4.821  1.00 13.69 ? 231 MET C N   1 
ATOM   6477 C  CA  . MET C 1 226 ? -10.392 -5.487  -6.057  1.00 14.29 ? 231 MET C CA  1 
ATOM   6478 C  C   . MET C 1 226 ? -8.978  -5.584  -6.655  1.00 14.47 ? 231 MET C C   1 
ATOM   6479 O  O   . MET C 1 226 ? -8.817  -5.701  -7.886  1.00 13.45 ? 231 MET C O   1 
ATOM   6480 C  CB  . MET C 1 226 ? -10.779 -4.017  -5.832  1.00 13.85 ? 231 MET C CB  1 
ATOM   6481 C  CG  . MET C 1 226 ? -12.249 -3.821  -5.429  1.00 15.04 ? 231 MET C CG  1 
ATOM   6482 S  SD  . MET C 1 226 ? -13.368 -4.792  -6.435  1.00 15.94 ? 231 MET C SD  1 
ATOM   6483 C  CE  . MET C 1 226 ? -13.117 -4.120  -8.053  1.00 15.87 ? 231 MET C CE  1 
ATOM   6484 N  N   . GLU C 1 227 ? -7.974  -5.539  -5.790  1.00 15.77 ? 232 GLU C N   1 
ATOM   6485 C  CA  . GLU C 1 227 ? -6.594  -5.690  -6.238  1.00 17.23 ? 232 GLU C CA  1 
ATOM   6486 C  C   . GLU C 1 227 ? -6.389  -7.006  -6.970  1.00 16.54 ? 232 GLU C C   1 
ATOM   6487 O  O   . GLU C 1 227 ? -5.775  -7.036  -8.044  1.00 16.51 ? 232 GLU C O   1 
ATOM   6488 C  CB  . GLU C 1 227 ? -5.603  -5.574  -5.064  1.00 18.46 ? 232 GLU C CB  1 
ATOM   6489 C  CG  . GLU C 1 227 ? -5.481  -4.192  -4.443  1.00 21.23 ? 232 GLU C CG  1 
ATOM   6490 C  CD  . GLU C 1 227 ? -4.551  -4.198  -3.212  1.00 26.07 ? 232 GLU C CD  1 
ATOM   6491 O  OE1 . GLU C 1 227 ? -4.160  -5.294  -2.747  1.00 26.25 ? 232 GLU C OE1 1 
ATOM   6492 O  OE2 . GLU C 1 227 ? -4.236  -3.098  -2.707  1.00 26.16 ? 232 GLU C OE2 1 
ATOM   6493 N  N   . ARG C 1 228 ? -6.916  -8.094  -6.404  1.00 16.06 ? 233 ARG C N   1 
ATOM   6494 C  CA  . ARG C 1 228 ? -6.729  -9.389  -6.998  1.00 16.09 ? 233 ARG C CA  1 
ATOM   6495 C  C   . ARG C 1 228 ? -7.522  -9.508  -8.268  1.00 15.90 ? 233 ARG C C   1 
ATOM   6496 O  O   . ARG C 1 228 ? -7.048  -10.100 -9.241  1.00 15.17 ? 233 ARG C O   1 
ATOM   6497 C  CB  . ARG C 1 228 ? -7.053  -10.499 -6.010  1.00 16.97 ? 233 ARG C CB  1 
ATOM   6498 C  CG  . ARG C 1 228 ? -6.056  -10.566 -4.878  1.00 19.26 ? 233 ARG C CG  1 
ATOM   6499 C  CD  . ARG C 1 228 ? -6.455  -11.629 -3.916  1.00 26.16 ? 233 ARG C CD  1 
ATOM   6500 N  NE  . ARG C 1 228 ? -5.486  -11.722 -2.839  1.00 28.76 ? 233 ARG C NE  1 
ATOM   6501 C  CZ  . ARG C 1 228 ? -5.320  -12.799 -2.079  1.00 32.01 ? 233 ARG C CZ  1 
ATOM   6502 N  NH1 . ARG C 1 228 ? -6.074  -13.880 -2.263  1.00 31.62 ? 233 ARG C NH1 1 
ATOM   6503 N  NH2 . ARG C 1 228 ? -4.398  -12.780 -1.126  1.00 32.34 ? 233 ARG C NH2 1 
ATOM   6504 N  N   . THR C 1 229 ? -8.736  -8.948  -8.258  1.00 15.89 ? 234 THR C N   1 
ATOM   6505 C  CA  . THR C 1 229 ? -9.588  -8.895  -9.450  1.00 15.65 ? 234 THR C CA  1 
ATOM   6506 C  C   . THR C 1 229 ? -8.855  -8.279  -10.654 1.00 16.25 ? 234 THR C C   1 
ATOM   6507 O  O   . THR C 1 229 ? -8.841  -8.854  -11.775 1.00 15.16 ? 234 THR C O   1 
ATOM   6508 C  CB  . THR C 1 229 ? -10.941 -8.159  -9.153  1.00 14.88 ? 234 THR C CB  1 
ATOM   6509 O  OG1 . THR C 1 229 ? -11.686 -8.927  -8.204  1.00 13.37 ? 234 THR C OG1 1 
ATOM   6510 C  CG2 . THR C 1 229 ? -11.799 -7.975  -10.478 1.00 14.50 ? 234 THR C CG2 1 
ATOM   6511 N  N   . PHE C 1 230 ? -8.233  -7.123  -10.428 1.00 17.03 ? 235 PHE C N   1 
ATOM   6512 C  CA  . PHE C 1 230 ? -7.546  -6.459  -11.520 1.00 18.23 ? 235 PHE C CA  1 
ATOM   6513 C  C   . PHE C 1 230 ? -6.272  -7.183  -11.887 1.00 18.70 ? 235 PHE C C   1 
ATOM   6514 O  O   . PHE C 1 230 ? -5.926  -7.245  -13.060 1.00 18.96 ? 235 PHE C O   1 
ATOM   6515 C  CB  . PHE C 1 230 ? -7.275  -4.987  -11.188 1.00 18.99 ? 235 PHE C CB  1 
ATOM   6516 C  CG  . PHE C 1 230 ? -8.529  -4.198  -10.996 1.00 20.35 ? 235 PHE C CG  1 
ATOM   6517 C  CD1 . PHE C 1 230 ? -9.606  -4.368  -11.870 1.00 22.83 ? 235 PHE C CD1 1 
ATOM   6518 C  CD2 . PHE C 1 230 ? -8.642  -3.283  -9.960  1.00 23.82 ? 235 PHE C CD2 1 
ATOM   6519 C  CE1 . PHE C 1 230 ? -10.795 -3.657  -11.710 1.00 25.72 ? 235 PHE C CE1 1 
ATOM   6520 C  CE2 . PHE C 1 230 ? -9.840  -2.544  -9.801  1.00 25.23 ? 235 PHE C CE2 1 
ATOM   6521 C  CZ  . PHE C 1 230 ? -10.919 -2.758  -10.668 1.00 23.38 ? 235 PHE C CZ  1 
ATOM   6522 N  N   . ASP C 1 231 ? -5.578  -7.725  -10.894 1.00 19.31 ? 236 ASP C N   1 
ATOM   6523 C  CA  . ASP C 1 231 ? -4.408  -8.553  -11.165 1.00 21.18 ? 236 ASP C CA  1 
ATOM   6524 C  C   . ASP C 1 231 ? -4.728  -9.697  -12.125 1.00 21.15 ? 236 ASP C C   1 
ATOM   6525 O  O   . ASP C 1 231 ? -4.024  -9.911  -13.121 1.00 20.41 ? 236 ASP C O   1 
ATOM   6526 C  CB  . ASP C 1 231 ? -3.827  -9.098  -9.876  1.00 22.60 ? 236 ASP C CB  1 
ATOM   6527 C  CG  . ASP C 1 231 ? -2.412  -9.570  -10.062 1.00 28.76 ? 236 ASP C CG  1 
ATOM   6528 O  OD1 . ASP C 1 231 ? -1.579  -8.776  -10.598 1.00 34.48 ? 236 ASP C OD1 1 
ATOM   6529 O  OD2 . ASP C 1 231 ? -2.132  -10.729 -9.709  1.00 32.64 ? 236 ASP C OD2 1 
ATOM   6530 N  N   . LEU C 1 232 ? -5.835  -10.378 -11.863 1.00 20.24 ? 237 LEU C N   1 
ATOM   6531 C  CA  . LEU C 1 232 ? -6.302  -11.480 -12.721 1.00 20.53 ? 237 LEU C CA  1 
ATOM   6532 C  C   . LEU C 1 232 ? -6.675  -11.037 -14.139 1.00 20.10 ? 237 LEU C C   1 
ATOM   6533 O  O   . LEU C 1 232 ? -6.316  -11.704 -15.127 1.00 19.71 ? 237 LEU C O   1 
ATOM   6534 C  CB  . LEU C 1 232 ? -7.497  -12.173 -12.086 1.00 19.63 ? 237 LEU C CB  1 
ATOM   6535 C  CG  . LEU C 1 232 ? -7.202  -13.061 -10.852 1.00 22.80 ? 237 LEU C CG  1 
ATOM   6536 C  CD1 . LEU C 1 232 ? -8.508  -13.313 -10.142 1.00 21.33 ? 237 LEU C CD1 1 
ATOM   6537 C  CD2 . LEU C 1 232 ? -6.483  -14.387 -11.213 1.00 20.77 ? 237 LEU C CD2 1 
ATOM   6538 N  N   . LEU C 1 233 ? -7.380  -9.910  -14.247 1.00 18.17 ? 238 LEU C N   1 
ATOM   6539 C  CA  . LEU C 1 233 ? -7.902  -9.528  -15.540 1.00 18.03 ? 238 LEU C CA  1 
ATOM   6540 C  C   . LEU C 1 233 ? -6.944  -8.636  -16.348 1.00 17.93 ? 238 LEU C C   1 
ATOM   6541 O  O   . LEU C 1 233 ? -6.817  -8.797  -17.550 1.00 17.51 ? 238 LEU C O   1 
ATOM   6542 C  CB  . LEU C 1 233 ? -9.270  -8.839  -15.387 1.00 17.48 ? 238 LEU C CB  1 
ATOM   6543 C  CG  . LEU C 1 233 ? -10.395 -9.683  -14.766 1.00 15.01 ? 238 LEU C CG  1 
ATOM   6544 C  CD1 . LEU C 1 233 ? -11.695 -8.848  -14.581 1.00 14.70 ? 238 LEU C CD1 1 
ATOM   6545 C  CD2 . LEU C 1 233 ? -10.656 -10.954 -15.599 1.00 15.19 ? 238 LEU C CD2 1 
ATOM   6546 N  N   . ILE C 1 234 ? -6.341  -7.652  -15.697 1.00 18.60 ? 239 ILE C N   1 
ATOM   6547 C  CA  . ILE C 1 234 ? -5.602  -6.602  -16.430 1.00 19.44 ? 239 ILE C CA  1 
ATOM   6548 C  C   . ILE C 1 234 ? -4.201  -6.488  -15.892 1.00 20.82 ? 239 ILE C C   1 
ATOM   6549 O  O   . ILE C 1 234 ? -3.536  -5.432  -16.044 1.00 22.01 ? 239 ILE C O   1 
ATOM   6550 C  CB  . ILE C 1 234 ? -6.302  -5.182  -16.397 1.00 19.80 ? 239 ILE C CB  1 
ATOM   6551 C  CG1 . ILE C 1 234 ? -6.474  -4.640  -14.939 1.00 17.25 ? 239 ILE C CG1 1 
ATOM   6552 C  CG2 . ILE C 1 234 ? -7.599  -5.183  -17.274 1.00 19.13 ? 239 ILE C CG2 1 
ATOM   6553 C  CD1 . ILE C 1 234 ? -6.967  -3.160  -14.853 1.00 17.64 ? 239 ILE C CD1 1 
ATOM   6554 N  N   . GLY C 1 235 ? -3.747  -7.545  -15.230 1.00 21.52 ? 240 GLY C N   1 
ATOM   6555 C  CA  . GLY C 1 235 ? -2.391  -7.557  -14.692 1.00 23.55 ? 240 GLY C CA  1 
ATOM   6556 C  C   . GLY C 1 235 ? -1.301  -7.555  -15.762 1.00 25.24 ? 240 GLY C C   1 
ATOM   6557 O  O   . GLY C 1 235 ? -0.225  -6.977  -15.554 1.00 24.92 ? 240 GLY C O   1 
ATOM   6558 N  N   . LYS C 1 236 ? -1.580  -8.183  -16.903 1.00 25.63 ? 241 LYS C N   1 
ATOM   6559 C  CA  . LYS C 1 236 ? -0.592  -8.305  -17.992 1.00 27.36 ? 241 LYS C CA  1 
ATOM   6560 C  C   . LYS C 1 236 ? -0.776  -7.260  -19.100 1.00 27.47 ? 241 LYS C C   1 
ATOM   6561 O  O   . LYS C 1 236 ? 0.197   -6.838  -19.752 1.00 27.26 ? 241 LYS C O   1 
ATOM   6562 C  CB  . LYS C 1 236 ? -0.659  -9.718  -18.580 1.00 27.16 ? 241 LYS C CB  1 
ATOM   6563 C  CG  . LYS C 1 236 ? -0.219  -10.816 -17.609 1.00 31.43 ? 241 LYS C CG  1 
ATOM   6564 C  CD  . LYS C 1 236 ? -0.666  -12.199 -18.110 1.00 36.18 ? 241 LYS C CD  1 
ATOM   6565 C  CE  . LYS C 1 236 ? -0.153  -13.300 -17.213 1.00 38.82 ? 241 LYS C CE  1 
ATOM   6566 N  NZ  . LYS C 1 236 ? 1.282   -13.624 -17.485 1.00 41.03 ? 241 LYS C NZ  1 
ATOM   6567 N  N   . ARG C 1 237 ? -2.016  -6.837  -19.326 1.00 26.81 ? 242 ARG C N   1 
ATOM   6568 C  CA  . ARG C 1 237 ? -2.286  -5.868  -20.391 1.00 27.19 ? 242 ARG C CA  1 
ATOM   6569 C  C   . ARG C 1 237 ? -3.562  -5.113  -20.098 1.00 26.88 ? 242 ARG C C   1 
ATOM   6570 O  O   . ARG C 1 237 ? -4.432  -5.631  -19.392 1.00 25.64 ? 242 ARG C O   1 
ATOM   6571 C  CB  . ARG C 1 237 ? -2.391  -6.593  -21.754 1.00 27.22 ? 242 ARG C CB  1 
ATOM   6572 C  CG  . ARG C 1 237 ? -3.705  -7.366  -21.959 1.00 29.09 ? 242 ARG C CG  1 
ATOM   6573 C  CD  . ARG C 1 237 ? -3.486  -8.663  -22.758 1.00 33.14 ? 242 ARG C CD  1 
ATOM   6574 N  NE  . ARG C 1 237 ? -4.726  -9.443  -22.884 1.00 33.12 ? 242 ARG C NE  1 
ATOM   6575 C  CZ  . ARG C 1 237 ? -5.059  -10.496 -22.135 1.00 30.89 ? 242 ARG C CZ  1 
ATOM   6576 N  NH1 . ARG C 1 237 ? -4.253  -10.944 -21.189 1.00 33.82 ? 242 ARG C NH1 1 
ATOM   6577 N  NH2 . ARG C 1 237 ? -6.204  -11.114 -22.334 1.00 27.58 ? 242 ARG C NH2 1 
ATOM   6578 N  N   . GLN C 1 238 ? -3.674  -3.904  -20.657 1.00 26.46 ? 243 GLN C N   1 
ATOM   6579 C  CA  . GLN C 1 238 ? -4.922  -3.139  -20.594 1.00 26.21 ? 243 GLN C CA  1 
ATOM   6580 C  C   . GLN C 1 238 ? -6.022  -3.750  -21.477 1.00 24.93 ? 243 GLN C C   1 
ATOM   6581 O  O   . GLN C 1 238 ? -5.752  -4.211  -22.583 1.00 24.57 ? 243 GLN C O   1 
ATOM   6582 C  CB  . GLN C 1 238 ? -4.670  -1.693  -20.989 1.00 27.79 ? 243 GLN C CB  1 
ATOM   6583 C  CG  . GLN C 1 238 ? -3.869  -0.917  -19.946 1.00 30.85 ? 243 GLN C CG  1 
ATOM   6584 C  CD  . GLN C 1 238 ? -3.270  0.339   -20.515 1.00 39.06 ? 243 GLN C CD  1 
ATOM   6585 O  OE1 . GLN C 1 238 ? -3.860  0.990   -21.391 1.00 41.91 ? 243 GLN C OE1 1 
ATOM   6586 N  NE2 . GLN C 1 238 ? -2.089  0.700   -20.026 1.00 40.71 ? 243 GLN C NE2 1 
ATOM   6587 N  N   . ARG C 1 239 ? -7.253  -3.733  -20.969 1.00 21.92 ? 244 ARG C N   1 
ATOM   6588 C  CA  . ARG C 1 239 ? -8.398  -4.346  -21.606 1.00 20.99 ? 244 ARG C CA  1 
ATOM   6589 C  C   . ARG C 1 239 ? -9.648  -3.530  -21.274 1.00 18.70 ? 244 ARG C C   1 
ATOM   6590 O  O   . ARG C 1 239 ? -9.760  -2.993  -20.149 1.00 18.49 ? 244 ARG C O   1 
ATOM   6591 C  CB  . ARG C 1 239 ? -8.605  -5.773  -21.077 1.00 20.37 ? 244 ARG C CB  1 
ATOM   6592 C  CG  . ARG C 1 239 ? -7.394  -6.704  -21.183 1.00 21.66 ? 244 ARG C CG  1 
ATOM   6593 C  CD  . ARG C 1 239 ? -7.664  -7.976  -20.421 1.00 22.74 ? 244 ARG C CD  1 
ATOM   6594 N  NE  . ARG C 1 239 ? -8.590  -8.868  -21.110 1.00 20.58 ? 244 ARG C NE  1 
ATOM   6595 C  CZ  . ARG C 1 239 ? -8.873  -10.096 -20.701 1.00 20.11 ? 244 ARG C CZ  1 
ATOM   6596 N  NH1 . ARG C 1 239 ? -8.340  -10.573 -19.576 1.00 20.77 ? 244 ARG C NH1 1 
ATOM   6597 N  NH2 . ARG C 1 239 ? -9.709  -10.841 -21.397 1.00 21.50 ? 244 ARG C NH2 1 
ATOM   6598 N  N   . PRO C 1 240 ? -10.598 -3.449  -22.215 1.00 17.65 ? 245 PRO C N   1 
ATOM   6599 C  CA  . PRO C 1 240 ? -11.852 -2.777  -21.865 1.00 17.09 ? 245 PRO C CA  1 
ATOM   6600 C  C   . PRO C 1 240 ? -12.611 -3.630  -20.835 1.00 17.08 ? 245 PRO C C   1 
ATOM   6601 O  O   . PRO C 1 240 ? -12.595 -4.850  -20.938 1.00 16.23 ? 245 PRO C O   1 
ATOM   6602 C  CB  . PRO C 1 240 ? -12.635 -2.742  -23.182 1.00 17.05 ? 245 PRO C CB  1 
ATOM   6603 C  CG  . PRO C 1 240 ? -11.935 -3.691  -24.093 1.00 17.43 ? 245 PRO C CG  1 
ATOM   6604 C  CD  . PRO C 1 240 ? -10.625 -4.059  -23.562 1.00 17.35 ? 245 PRO C CD  1 
ATOM   6605 N  N   . ILE C 1 241 ? -13.289 -2.972  -19.890 1.00 16.42 ? 246 ILE C N   1 
ATOM   6606 C  CA  . ILE C 1 241 ? -13.988 -3.654  -18.809 1.00 15.25 ? 246 ILE C CA  1 
ATOM   6607 C  C   . ILE C 1 241 ? -15.472 -3.483  -18.987 1.00 15.26 ? 246 ILE C C   1 
ATOM   6608 O  O   . ILE C 1 241 ? -15.969 -2.358  -19.289 1.00 16.02 ? 246 ILE C O   1 
ATOM   6609 C  CB  . ILE C 1 241 ? -13.550 -3.134  -17.415 1.00 15.75 ? 246 ILE C CB  1 
ATOM   6610 C  CG1 . ILE C 1 241 ? -12.032 -3.317  -17.212 1.00 15.64 ? 246 ILE C CG1 1 
ATOM   6611 C  CG2 . ILE C 1 241 ? -14.350 -3.804  -16.268 1.00 15.24 ? 246 ILE C CG2 1 
ATOM   6612 C  CD1 . ILE C 1 241 ? -11.448 -2.626  -15.893 1.00 16.30 ? 246 ILE C CD1 1 
ATOM   6613 N  N   . HIS C 1 242 ? -16.173 -4.602  -18.798 1.00 14.02 ? 247 HIS C N   1 
ATOM   6614 C  CA  . HIS C 1 242 ? -17.613 -4.600  -18.782 1.00 14.30 ? 247 HIS C CA  1 
ATOM   6615 C  C   . HIS C 1 242 ? -18.011 -4.922  -17.342 1.00 14.59 ? 247 HIS C C   1 
ATOM   6616 O  O   . HIS C 1 242 ? -17.738 -6.030  -16.852 1.00 14.23 ? 247 HIS C O   1 
ATOM   6617 C  CB  . HIS C 1 242 ? -18.139 -5.670  -19.741 1.00 14.94 ? 247 HIS C CB  1 
ATOM   6618 C  CG  . HIS C 1 242 ? -19.629 -5.654  -19.880 1.00 17.31 ? 247 HIS C CG  1 
ATOM   6619 N  ND1 . HIS C 1 242 ? -20.266 -5.266  -21.034 1.00 17.01 ? 247 HIS C ND1 1 
ATOM   6620 C  CD2 . HIS C 1 242 ? -20.605 -5.927  -18.984 1.00 16.11 ? 247 HIS C CD2 1 
ATOM   6621 C  CE1 . HIS C 1 242 ? -21.575 -5.326  -20.856 1.00 16.81 ? 247 HIS C CE1 1 
ATOM   6622 N  NE2 . HIS C 1 242 ? -21.807 -5.738  -19.620 1.00 17.83 ? 247 HIS C NE2 1 
ATOM   6623 N  N   . LEU C 1 243 ? -18.617 -3.947  -16.663 1.00 14.10 ? 248 LEU C N   1 
ATOM   6624 C  CA  . LEU C 1 243 ? -19.105 -4.159  -15.290 1.00 14.05 ? 248 LEU C CA  1 
ATOM   6625 C  C   . LEU C 1 243 ? -20.570 -4.513  -15.357 1.00 14.78 ? 248 LEU C C   1 
ATOM   6626 O  O   . LEU C 1 243 ? -21.371 -3.696  -15.788 1.00 15.82 ? 248 LEU C O   1 
ATOM   6627 C  CB  . LEU C 1 243 ? -18.963 -2.881  -14.455 1.00 13.82 ? 248 LEU C CB  1 
ATOM   6628 C  CG  . LEU C 1 243 ? -19.492 -2.851  -13.017 1.00 13.04 ? 248 LEU C CG  1 
ATOM   6629 C  CD1 . LEU C 1 243 ? -18.949 -4.003  -12.190 1.00 12.15 ? 248 LEU C CD1 1 
ATOM   6630 C  CD2 . LEU C 1 243 ? -19.133 -1.488  -12.340 1.00 13.29 ? 248 LEU C CD2 1 
ATOM   6631 N  N   . SER C 1 244 ? -20.919 -5.720  -14.954 1.00 14.38 ? 249 SER C N   1 
ATOM   6632 C  CA  . SER C 1 244 ? -22.310 -6.123  -14.965 1.00 15.48 ? 249 SER C CA  1 
ATOM   6633 C  C   . SER C 1 244 ? -22.753 -6.146  -13.515 1.00 15.19 ? 249 SER C C   1 
ATOM   6634 O  O   . SER C 1 244 ? -22.360 -7.032  -12.735 1.00 15.03 ? 249 SER C O   1 
ATOM   6635 C  CB  . SER C 1 244 ? -22.523 -7.478  -15.670 1.00 15.28 ? 249 SER C CB  1 
ATOM   6636 O  OG  . SER C 1 244 ? -23.913 -7.640  -15.884 1.00 16.15 ? 249 SER C OG  1 
ATOM   6637 N  N   . PHE C 1 245 ? -23.506 -5.130  -13.135 1.00 13.71 ? 250 PHE C N   1 
ATOM   6638 C  CA  . PHE C 1 245 ? -23.791 -4.913  -11.707 1.00 13.82 ? 250 PHE C CA  1 
ATOM   6639 C  C   . PHE C 1 245 ? -25.244 -5.136  -11.389 1.00 14.33 ? 250 PHE C C   1 
ATOM   6640 O  O   . PHE C 1 245 ? -26.099 -4.371  -11.850 1.00 14.87 ? 250 PHE C O   1 
ATOM   6641 C  CB  . PHE C 1 245 ? -23.350 -3.500  -11.300 1.00 12.97 ? 250 PHE C CB  1 
ATOM   6642 C  CG  . PHE C 1 245 ? -23.088 -3.319  -9.819  1.00 15.19 ? 250 PHE C CG  1 
ATOM   6643 C  CD1 . PHE C 1 245 ? -24.129 -3.496  -8.880  1.00 15.71 ? 250 PHE C CD1 1 
ATOM   6644 C  CD2 . PHE C 1 245 ? -21.832 -2.911  -9.353  1.00 12.94 ? 250 PHE C CD2 1 
ATOM   6645 C  CE1 . PHE C 1 245 ? -23.895 -3.290  -7.498  1.00 16.74 ? 250 PHE C CE1 1 
ATOM   6646 C  CE2 . PHE C 1 245 ? -21.603 -2.717  -7.984  1.00 14.26 ? 250 PHE C CE2 1 
ATOM   6647 C  CZ  . PHE C 1 245 ? -22.619 -2.896  -7.062  1.00 14.49 ? 250 PHE C CZ  1 
ATOM   6648 N  N   . ASP C 1 246 ? -25.509 -6.184  -10.603 1.00 14.32 ? 251 ASP C N   1 
ATOM   6649 C  CA  . ASP C 1 246 ? -26.842 -6.503  -10.116 1.00 15.16 ? 251 ASP C CA  1 
ATOM   6650 C  C   . ASP C 1 246 ? -27.021 -5.847  -8.743  1.00 15.30 ? 251 ASP C C   1 
ATOM   6651 O  O   . ASP C 1 246 ? -26.225 -6.041  -7.817  1.00 14.90 ? 251 ASP C O   1 
ATOM   6652 C  CB  . ASP C 1 246 ? -26.989 -8.026  -10.070 1.00 14.59 ? 251 ASP C CB  1 
ATOM   6653 C  CG  . ASP C 1 246 ? -28.401 -8.513  -9.726  1.00 18.15 ? 251 ASP C CG  1 
ATOM   6654 O  OD1 . ASP C 1 246 ? -29.225 -7.746  -9.196  1.00 18.32 ? 251 ASP C OD1 1 
ATOM   6655 O  OD2 . ASP C 1 246 ? -28.641 -9.732  -9.923  1.00 21.00 ? 251 ASP C OD2 1 
ATOM   6656 N  N   . ILE C 1 247 ? -28.043 -5.013  -8.643  1.00 15.30 ? 252 ILE C N   1 
ATOM   6657 C  CA  . ILE C 1 247 ? -28.346 -4.319  -7.394  1.00 15.18 ? 252 ILE C CA  1 
ATOM   6658 C  C   . ILE C 1 247 ? -28.528 -5.278  -6.212  1.00 14.30 ? 252 ILE C C   1 
ATOM   6659 O  O   . ILE C 1 247 ? -28.323 -4.898  -5.046  1.00 14.14 ? 252 ILE C O   1 
ATOM   6660 C  CB  . ILE C 1 247 ? -29.609 -3.419  -7.568  1.00 15.43 ? 252 ILE C CB  1 
ATOM   6661 C  CG1 . ILE C 1 247 ? -29.623 -2.282  -6.525  1.00 16.72 ? 252 ILE C CG1 1 
ATOM   6662 C  CG2 . ILE C 1 247 ? -30.854 -4.267  -7.516  1.00 16.48 ? 252 ILE C CG2 1 
ATOM   6663 C  CD1 . ILE C 1 247 ? -28.608 -1.160  -6.767  1.00 13.01 ? 252 ILE C CD1 1 
ATOM   6664 N  N   . ASP C 1 248 ? -28.920 -6.516  -6.505  1.00 14.33 ? 253 ASP C N   1 
ATOM   6665 C  CA  . ASP C 1 248 ? -29.034 -7.520  -5.452  1.00 15.14 ? 253 ASP C CA  1 
ATOM   6666 C  C   . ASP C 1 248 ? -27.676 -7.988  -4.893  1.00 13.89 ? 253 ASP C C   1 
ATOM   6667 O  O   . ASP C 1 248 ? -27.643 -8.725  -3.908  1.00 13.99 ? 253 ASP C O   1 
ATOM   6668 C  CB  . ASP C 1 248 ? -30.017 -8.678  -5.807  1.00 15.78 ? 253 ASP C CB  1 
ATOM   6669 C  CG  . ASP C 1 248 ? -29.447 -9.697  -6.789  1.00 18.90 ? 253 ASP C CG  1 
ATOM   6670 O  OD1 . ASP C 1 248 ? -28.201 -9.820  -6.928  1.00 17.03 ? 253 ASP C OD1 1 
ATOM   6671 O  OD2 . ASP C 1 248 ? -30.274 -10.412 -7.432  1.00 17.76 ? 253 ASP C OD2 1 
ATOM   6672 N  N   . ALA C 1 249 ? -26.576 -7.493  -5.471  1.00 14.19 ? 254 ALA C N   1 
ATOM   6673 C  CA  . ALA C 1 249 ? -25.260 -7.665  -4.828  1.00 13.17 ? 254 ALA C CA  1 
ATOM   6674 C  C   . ALA C 1 249 ? -25.269 -7.052  -3.406  1.00 14.16 ? 254 ALA C C   1 
ATOM   6675 O  O   . ALA C 1 249 ? -24.649 -7.582  -2.484  1.00 14.77 ? 254 ALA C O   1 
ATOM   6676 C  CB  . ALA C 1 249 ? -24.198 -7.014  -5.648  1.00 12.85 ? 254 ALA C CB  1 
ATOM   6677 N  N   . PHE C 1 250 ? -25.951 -5.913  -3.256  1.00 13.34 ? 255 PHE C N   1 
ATOM   6678 C  CA  . PHE C 1 250 ? -26.052 -5.216  -1.972  1.00 13.61 ? 255 PHE C CA  1 
ATOM   6679 C  C   . PHE C 1 250 ? -26.981 -5.953  -1.008  1.00 13.62 ? 255 PHE C C   1 
ATOM   6680 O  O   . PHE C 1 250 ? -27.935 -6.636  -1.413  1.00 13.30 ? 255 PHE C O   1 
ATOM   6681 C  CB  . PHE C 1 250 ? -26.636 -3.806  -2.188  1.00 13.62 ? 255 PHE C CB  1 
ATOM   6682 C  CG  . PHE C 1 250 ? -25.673 -2.807  -2.780  1.00 14.15 ? 255 PHE C CG  1 
ATOM   6683 C  CD1 . PHE C 1 250 ? -24.606 -2.302  -2.024  1.00 13.30 ? 255 PHE C CD1 1 
ATOM   6684 C  CD2 . PHE C 1 250 ? -25.831 -2.370  -4.102  1.00 11.32 ? 255 PHE C CD2 1 
ATOM   6685 C  CE1 . PHE C 1 250 ? -23.711 -1.355  -2.568  1.00 12.86 ? 255 PHE C CE1 1 
ATOM   6686 C  CE2 . PHE C 1 250 ? -24.955 -1.437  -4.651  1.00 14.83 ? 255 PHE C CE2 1 
ATOM   6687 C  CZ  . PHE C 1 250 ? -23.889 -0.920  -3.887  1.00 16.08 ? 255 PHE C CZ  1 
ATOM   6688 N  N   . ASP C 1 251 ? -26.764 -5.751  0.283   1.00 13.89 ? 256 ASP C N   1 
ATOM   6689 C  CA  . ASP C 1 251 ? -27.642 -6.313  1.267   1.00 14.16 ? 256 ASP C CA  1 
ATOM   6690 C  C   . ASP C 1 251 ? -29.067 -5.844  1.002   1.00 14.54 ? 256 ASP C C   1 
ATOM   6691 O  O   . ASP C 1 251 ? -29.243 -4.695  0.594   1.00 14.53 ? 256 ASP C O   1 
ATOM   6692 C  CB  . ASP C 1 251 ? -27.221 -5.880  2.677   1.00 14.56 ? 256 ASP C CB  1 
ATOM   6693 C  CG  . ASP C 1 251 ? -27.871 -6.739  3.726   1.00 16.08 ? 256 ASP C CG  1 
ATOM   6694 O  OD1 . ASP C 1 251 ? -28.861 -6.279  4.306   1.00 17.68 ? 256 ASP C OD1 1 
ATOM   6695 O  OD2 . ASP C 1 251 ? -27.439 -7.897  3.922   1.00 20.18 ? 256 ASP C OD2 1 
ATOM   6696 N  N   . PRO C 1 252 ? -30.080 -6.716  1.227   1.00 15.78 ? 257 PRO C N   1 
ATOM   6697 C  CA  . PRO C 1 252 ? -31.471 -6.283  0.987   1.00 17.39 ? 257 PRO C CA  1 
ATOM   6698 C  C   . PRO C 1 252 ? -31.957 -5.173  1.902   1.00 18.35 ? 257 PRO C C   1 
ATOM   6699 O  O   . PRO C 1 252 ? -32.934 -4.513  1.569   1.00 19.21 ? 257 PRO C O   1 
ATOM   6700 C  CB  . PRO C 1 252 ? -32.291 -7.537  1.318   1.00 18.20 ? 257 PRO C CB  1 
ATOM   6701 C  CG  . PRO C 1 252 ? -31.355 -8.649  1.068   1.00 17.18 ? 257 PRO C CG  1 
ATOM   6702 C  CD  . PRO C 1 252 ? -30.018 -8.164  1.478   1.00 15.79 ? 257 PRO C CD  1 
ATOM   6703 N  N   . THR C 1 253 ? -31.297 -4.938  3.031   1.00 19.14 ? 258 THR C N   1 
ATOM   6704 C  CA  . THR C 1 253 ? -31.634 -3.754  3.820   1.00 19.86 ? 258 THR C CA  1 
ATOM   6705 C  C   . THR C 1 253 ? -31.308 -2.456  3.086   1.00 19.85 ? 258 THR C C   1 
ATOM   6706 O  O   . THR C 1 253 ? -31.966 -1.425  3.311   1.00 19.48 ? 258 THR C O   1 
ATOM   6707 C  CB  . THR C 1 253 ? -30.993 -3.802  5.223   1.00 20.98 ? 258 THR C CB  1 
ATOM   6708 O  OG1 . THR C 1 253 ? -29.556 -3.804  5.065   1.00 23.81 ? 258 THR C OG1 1 
ATOM   6709 C  CG2 . THR C 1 253 ? -31.456 -5.100  5.916   1.00 18.23 ? 258 THR C CG2 1 
ATOM   6710 N  N   . LEU C 1 254 ? -30.305 -2.489  2.192   1.00 18.67 ? 259 LEU C N   1 
ATOM   6711 C  CA  . LEU C 1 254 ? -29.957 -1.335  1.355   1.00 19.04 ? 259 LEU C CA  1 
ATOM   6712 C  C   . LEU C 1 254 ? -30.668 -1.307  -0.012  1.00 18.90 ? 259 LEU C C   1 
ATOM   6713 O  O   . LEU C 1 254 ? -30.941 -0.235  -0.553  1.00 19.02 ? 259 LEU C O   1 
ATOM   6714 C  CB  . LEU C 1 254 ? -28.439 -1.303  1.081   1.00 18.42 ? 259 LEU C CB  1 
ATOM   6715 C  CG  . LEU C 1 254 ? -27.533 -1.338  2.309   1.00 19.96 ? 259 LEU C CG  1 
ATOM   6716 C  CD1 . LEU C 1 254 ? -26.071 -1.642  1.858   1.00 20.84 ? 259 LEU C CD1 1 
ATOM   6717 C  CD2 . LEU C 1 254 ? -27.629 0.013   3.087   1.00 22.02 ? 259 LEU C CD2 1 
ATOM   6718 N  N   . ALA C 1 255 ? -30.904 -2.484  -0.580  1.00 18.30 ? 260 ALA C N   1 
ATOM   6719 C  CA  . ALA C 1 255 ? -31.500 -2.614  -1.909  1.00 18.90 ? 260 ALA C CA  1 
ATOM   6720 C  C   . ALA C 1 255 ? -32.669 -3.616  -1.850  1.00 19.10 ? 260 ALA C C   1 
ATOM   6721 O  O   . ALA C 1 255 ? -32.590 -4.744  -2.360  1.00 18.46 ? 260 ALA C O   1 
ATOM   6722 C  CB  . ALA C 1 255 ? -30.394 -3.010  -2.971  1.00 18.01 ? 260 ALA C CB  1 
ATOM   6723 N  N   . PRO C 1 256 ? -33.771 -3.211  -1.180  1.00 19.95 ? 261 PRO C N   1 
ATOM   6724 C  CA  . PRO C 1 256 ? -34.897 -4.125  -0.959  1.00 20.75 ? 261 PRO C CA  1 
ATOM   6725 C  C   . PRO C 1 256 ? -35.754 -4.344  -2.206  1.00 21.15 ? 261 PRO C C   1 
ATOM   6726 O  O   . PRO C 1 256 ? -36.366 -5.400  -2.340  1.00 21.26 ? 261 PRO C O   1 
ATOM   6727 C  CB  . PRO C 1 256 ? -35.709 -3.424  0.164   1.00 21.17 ? 261 PRO C CB  1 
ATOM   6728 C  CG  . PRO C 1 256 ? -35.395 -1.969  0.017   1.00 20.84 ? 261 PRO C CG  1 
ATOM   6729 C  CD  . PRO C 1 256 ? -33.911 -1.964  -0.385  1.00 20.11 ? 261 PRO C CD  1 
ATOM   6730 N  N   . ALA C 1 257 ? -35.754 -3.374  -3.118  1.00 21.22 ? 262 ALA C N   1 
ATOM   6731 C  CA  . ALA C 1 257 ? -36.596 -3.417  -4.307  1.00 21.34 ? 262 ALA C CA  1 
ATOM   6732 C  C   . ALA C 1 257 ? -35.965 -4.252  -5.441  1.00 20.89 ? 262 ALA C C   1 
ATOM   6733 O  O   . ALA C 1 257 ? -35.476 -3.701  -6.424  1.00 21.77 ? 262 ALA C O   1 
ATOM   6734 C  CB  . ALA C 1 257 ? -36.875 -2.015  -4.790  1.00 20.14 ? 262 ALA C CB  1 
ATOM   6735 N  N   . THR C 1 258 ? -35.986 -5.576  -5.287  1.00 21.81 ? 263 THR C N   1 
ATOM   6736 C  CA  . THR C 1 258 ? -35.334 -6.481  -6.221  1.00 21.04 ? 263 THR C CA  1 
ATOM   6737 C  C   . THR C 1 258 ? -35.951 -7.841  -6.033  1.00 21.66 ? 263 THR C C   1 
ATOM   6738 O  O   . THR C 1 258 ? -36.419 -8.156  -4.937  1.00 22.17 ? 263 THR C O   1 
ATOM   6739 C  CB  . THR C 1 258 ? -33.764 -6.492  -6.047  1.00 21.61 ? 263 THR C CB  1 
ATOM   6740 O  OG1 . THR C 1 258 ? -33.164 -7.085  -7.207  1.00 19.73 ? 263 THR C OG1 1 
ATOM   6741 C  CG2 . THR C 1 258 ? -33.327 -7.274  -4.788  1.00 21.07 ? 263 THR C CG2 1 
ATOM   6742 N  N   . GLY C 1 259 ? -35.966 -8.650  -7.088  1.00 21.63 ? 264 GLY C N   1 
ATOM   6743 C  CA  . GLY C 1 259 ? -36.777 -9.888  -7.100  1.00 21.69 ? 264 GLY C CA  1 
ATOM   6744 C  C   . GLY C 1 259 ? -36.164 -11.100 -6.449  1.00 21.98 ? 264 GLY C C   1 
ATOM   6745 O  O   . GLY C 1 259 ? -36.876 -12.020 -6.053  1.00 22.95 ? 264 GLY C O   1 
ATOM   6746 N  N   . THR C 1 260 ? -34.833 -11.118 -6.347  1.00 21.47 ? 265 THR C N   1 
ATOM   6747 C  CA  . THR C 1 260 ? -34.137 -12.249 -5.732  1.00 22.65 ? 265 THR C CA  1 
ATOM   6748 C  C   . THR C 1 260 ? -33.155 -11.767 -4.639  1.00 21.68 ? 265 THR C C   1 
ATOM   6749 O  O   . THR C 1 260 ? -31.932 -11.971 -4.749  1.00 21.58 ? 265 THR C O   1 
ATOM   6750 C  CB  . THR C 1 260 ? -33.435 -13.116 -6.822  1.00 22.41 ? 265 THR C CB  1 
ATOM   6751 O  OG1 . THR C 1 260 ? -34.334 -13.322 -7.919  1.00 27.87 ? 265 THR C OG1 1 
ATOM   6752 C  CG2 . THR C 1 260 ? -33.107 -14.467 -6.296  1.00 25.87 ? 265 THR C CG2 1 
ATOM   6753 N  N   . PRO C 1 261 ? -33.693 -11.119 -3.576  1.00 21.38 ? 266 PRO C N   1 
ATOM   6754 C  CA  . PRO C 1 261 ? -32.850 -10.629 -2.482  1.00 19.68 ? 266 PRO C CA  1 
ATOM   6755 C  C   . PRO C 1 261 ? -32.211 -11.770 -1.694  1.00 19.72 ? 266 PRO C C   1 
ATOM   6756 O  O   . PRO C 1 261 ? -32.813 -12.831 -1.520  1.00 18.79 ? 266 PRO C O   1 
ATOM   6757 C  CB  . PRO C 1 261 ? -33.825 -9.838  -1.614  1.00 21.18 ? 266 PRO C CB  1 
ATOM   6758 C  CG  . PRO C 1 261 ? -35.186 -10.591 -1.808  1.00 20.61 ? 266 PRO C CG  1 
ATOM   6759 C  CD  . PRO C 1 261 ? -35.143 -11.125 -3.225  1.00 20.91 ? 266 PRO C CD  1 
ATOM   6760 N  N   . VAL C 1 262 ? -30.964 -11.594 -1.267  1.00 16.78 ? 267 VAL C N   1 
ATOM   6761 C  CA  . VAL C 1 262 ? -30.339 -12.631 -0.458  1.00 17.17 ? 267 VAL C CA  1 
ATOM   6762 C  C   . VAL C 1 262 ? -29.648 -11.912 0.679   1.00 16.63 ? 267 VAL C C   1 
ATOM   6763 O  O   . VAL C 1 262 ? -28.873 -10.991 0.449   1.00 16.59 ? 267 VAL C O   1 
ATOM   6764 C  CB  . VAL C 1 262 ? -29.291 -13.509 -1.239  1.00 16.73 ? 267 VAL C CB  1 
ATOM   6765 C  CG1 . VAL C 1 262 ? -28.691 -14.596 -0.314  1.00 17.41 ? 267 VAL C CG1 1 
ATOM   6766 C  CG2 . VAL C 1 262 ? -29.940 -14.180 -2.430  1.00 17.41 ? 267 VAL C CG2 1 
ATOM   6767 N  N   . VAL C 1 263 ? -29.920 -12.333 1.908   1.00 16.24 ? 268 VAL C N   1 
ATOM   6768 C  CA  . VAL C 1 263 ? -29.376 -11.620 3.063   1.00 16.25 ? 268 VAL C CA  1 
ATOM   6769 C  C   . VAL C 1 263 ? -27.838 -11.758 3.117   1.00 15.81 ? 268 VAL C C   1 
ATOM   6770 O  O   . VAL C 1 263 ? -27.280 -12.727 2.587   1.00 15.54 ? 268 VAL C O   1 
ATOM   6771 C  CB  . VAL C 1 263 ? -30.046 -12.130 4.371   1.00 17.66 ? 268 VAL C CB  1 
ATOM   6772 C  CG1 . VAL C 1 263 ? -31.545 -11.705 4.403   1.00 16.85 ? 268 VAL C CG1 1 
ATOM   6773 C  CG2 . VAL C 1 263 ? -29.932 -13.636 4.472   1.00 16.88 ? 268 VAL C CG2 1 
ATOM   6774 N  N   . GLY C 1 264 ? -27.193 -10.787 3.767   1.00 14.56 ? 269 GLY C N   1 
ATOM   6775 C  CA  . GLY C 1 264 ? -25.754 -10.753 3.981   1.00 14.45 ? 269 GLY C CA  1 
ATOM   6776 C  C   . GLY C 1 264 ? -24.960 -10.282 2.759   1.00 14.12 ? 269 GLY C C   1 
ATOM   6777 O  O   . GLY C 1 264 ? -23.928 -10.874 2.419   1.00 14.18 ? 269 GLY C O   1 
ATOM   6778 N  N   . GLY C 1 265 ? -25.427 -9.204  2.126   1.00 13.53 ? 270 GLY C N   1 
ATOM   6779 C  CA  . GLY C 1 265 ? -24.783 -8.669  0.924   1.00 13.07 ? 270 GLY C CA  1 
ATOM   6780 C  C   . GLY C 1 265 ? -23.768 -7.588  1.200   1.00 12.50 ? 270 GLY C C   1 
ATOM   6781 O  O   . GLY C 1 265 ? -23.392 -7.338  2.351   1.00 10.99 ? 270 GLY C O   1 
ATOM   6782 N  N   . LEU C 1 266 ? -23.301 -6.971  0.118   1.00 11.67 ? 271 LEU C N   1 
ATOM   6783 C  CA  . LEU C 1 266 ? -22.407 -5.815  0.193   1.00 13.10 ? 271 LEU C CA  1 
ATOM   6784 C  C   . LEU C 1 266 ? -23.000 -4.691  1.026   1.00 12.96 ? 271 LEU C C   1 
ATOM   6785 O  O   . LEU C 1 266 ? -24.223 -4.427  0.985   1.00 13.19 ? 271 LEU C O   1 
ATOM   6786 C  CB  . LEU C 1 266 ? -22.111 -5.276  -1.222  1.00 11.25 ? 271 LEU C CB  1 
ATOM   6787 C  CG  . LEU C 1 266 ? -21.435 -6.237  -2.233  1.00 13.52 ? 271 LEU C CG  1 
ATOM   6788 C  CD1 . LEU C 1 266 ? -21.381 -5.537  -3.581  1.00 13.56 ? 271 LEU C CD1 1 
ATOM   6789 C  CD2 . LEU C 1 266 ? -20.020 -6.642  -1.791  1.00 13.15 ? 271 LEU C CD2 1 
ATOM   6790 N  N   . THR C 1 267 ? -22.131 -4.012  1.762   1.00 13.56 ? 272 THR C N   1 
ATOM   6791 C  CA  . THR C 1 267 ? -22.508 -2.766  2.424   1.00 13.15 ? 272 THR C CA  1 
ATOM   6792 C  C   . THR C 1 267 ? -22.490 -1.632  1.390   1.00 13.02 ? 272 THR C C   1 
ATOM   6793 O  O   . THR C 1 267 ? -21.989 -1.813  0.274   1.00 10.77 ? 272 THR C O   1 
ATOM   6794 C  CB  . THR C 1 267 ? -21.554 -2.404  3.549   1.00 13.92 ? 272 THR C CB  1 
ATOM   6795 O  OG1 . THR C 1 267 ? -20.247 -2.110  3.006   1.00 12.26 ? 272 THR C OG1 1 
ATOM   6796 C  CG2 . THR C 1 267 ? -21.472 -3.578  4.646   1.00 13.66 ? 272 THR C CG2 1 
ATOM   6797 N  N   . TYR C 1 268 ? -23.022 -0.464  1.763   1.00 12.80 ? 273 TYR C N   1 
ATOM   6798 C  CA  . TYR C 1 268 ? -22.959 0.700   0.887   1.00 13.31 ? 273 TYR C CA  1 
ATOM   6799 C  C   . TYR C 1 268 ? -21.499 1.033   0.551   1.00 13.71 ? 273 TYR C C   1 
ATOM   6800 O  O   . TYR C 1 268 ? -21.146 1.273   -0.619  1.00 13.39 ? 273 TYR C O   1 
ATOM   6801 C  CB  . TYR C 1 268 ? -23.642 1.903   1.540   1.00 13.79 ? 273 TYR C CB  1 
ATOM   6802 C  CG  . TYR C 1 268 ? -23.587 3.163   0.682   1.00 15.61 ? 273 TYR C CG  1 
ATOM   6803 C  CD1 . TYR C 1 268 ? -24.587 3.436   -0.256  1.00 13.86 ? 273 TYR C CD1 1 
ATOM   6804 C  CD2 . TYR C 1 268 ? -22.530 4.078   0.813   1.00 15.24 ? 273 TYR C CD2 1 
ATOM   6805 C  CE1 . TYR C 1 268 ? -24.526 4.571   -1.051  1.00 15.05 ? 273 TYR C CE1 1 
ATOM   6806 C  CE2 . TYR C 1 268 ? -22.474 5.227   0.043   1.00 14.69 ? 273 TYR C CE2 1 
ATOM   6807 C  CZ  . TYR C 1 268 ? -23.469 5.464   -0.887  1.00 16.08 ? 273 TYR C CZ  1 
ATOM   6808 O  OH  . TYR C 1 268 ? -23.405 6.584   -1.681  1.00 18.46 ? 273 TYR C OH  1 
ATOM   6809 N  N   . ARG C 1 269 ? -20.667 1.066   1.588   1.00 12.08 ? 274 ARG C N   1 
ATOM   6810 C  CA  . ARG C 1 269 ? -19.232 1.354   1.423   1.00 12.47 ? 274 ARG C CA  1 
ATOM   6811 C  C   . ARG C 1 269 ? -18.501 0.402   0.490   1.00 12.76 ? 274 ARG C C   1 
ATOM   6812 O  O   . ARG C 1 269 ? -17.687 0.844   -0.317  1.00 13.63 ? 274 ARG C O   1 
ATOM   6813 C  CB  . ARG C 1 269 ? -18.543 1.406   2.791   1.00 11.41 ? 274 ARG C CB  1 
ATOM   6814 C  CG  . ARG C 1 269 ? -18.932 2.662   3.616   1.00 12.23 ? 274 ARG C CG  1 
ATOM   6815 C  CD  . ARG C 1 269 ? -18.783 2.468   5.142   1.00 10.85 ? 274 ARG C CD  1 
ATOM   6816 N  NE  . ARG C 1 269 ? -17.409 2.114   5.511   1.00 13.54 ? 274 ARG C NE  1 
ATOM   6817 C  CZ  . ARG C 1 269 ? -16.989 1.925   6.754   1.00 13.12 ? 274 ARG C CZ  1 
ATOM   6818 N  NH1 . ARG C 1 269 ? -17.812 2.134   7.770   1.00 8.42  ? 274 ARG C NH1 1 
ATOM   6819 N  NH2 . ARG C 1 269 ? -15.705 1.566   6.985   1.00 9.69  ? 274 ARG C NH2 1 
ATOM   6820 N  N   . GLU C 1 270 ? -18.713 -0.905  0.634   1.00 13.45 ? 275 GLU C N   1 
ATOM   6821 C  CA  . GLU C 1 270 ? -18.030 -1.875  -0.242  1.00 13.14 ? 275 GLU C CA  1 
ATOM   6822 C  C   . GLU C 1 270 ? -18.451 -1.668  -1.687  1.00 13.59 ? 275 GLU C C   1 
ATOM   6823 O  O   . GLU C 1 270 ? -17.628 -1.772  -2.596  1.00 12.95 ? 275 GLU C O   1 
ATOM   6824 C  CB  . GLU C 1 270 ? -18.314 -3.325  0.182   1.00 13.66 ? 275 GLU C CB  1 
ATOM   6825 C  CG  . GLU C 1 270 ? -17.673 -3.710  1.527   1.00 13.88 ? 275 GLU C CG  1 
ATOM   6826 C  CD  . GLU C 1 270 ? -18.209 -5.011  2.127   1.00 12.79 ? 275 GLU C CD  1 
ATOM   6827 O  OE1 . GLU C 1 270 ? -19.419 -5.344  1.942   1.00 11.85 ? 275 GLU C OE1 1 
ATOM   6828 O  OE2 . GLU C 1 270 ? -17.410 -5.697  2.821   1.00 11.98 ? 275 GLU C OE2 1 
ATOM   6829 N  N   . GLY C 1 271 ? -19.750 -1.428  -1.902  1.00 13.46 ? 276 GLY C N   1 
ATOM   6830 C  CA  . GLY C 1 271 ? -20.247 -1.254  -3.264  1.00 14.24 ? 276 GLY C CA  1 
ATOM   6831 C  C   . GLY C 1 271 ? -19.671 -0.017  -3.926  1.00 14.15 ? 276 GLY C C   1 
ATOM   6832 O  O   . GLY C 1 271 ? -19.325 -0.060  -5.120  1.00 15.47 ? 276 GLY C O   1 
ATOM   6833 N  N   . MET C 1 272 ? -19.564 1.078   -3.168  1.00 13.28 ? 277 MET C N   1 
ATOM   6834 C  CA  . MET C 1 272 ? -18.961 2.301   -3.688  1.00 14.72 ? 277 MET C CA  1 
ATOM   6835 C  C   . MET C 1 272 ? -17.508 2.035   -3.974  1.00 14.42 ? 277 MET C C   1 
ATOM   6836 O  O   . MET C 1 272 ? -17.000 2.509   -4.989  1.00 12.85 ? 277 MET C O   1 
ATOM   6837 C  CB  . MET C 1 272 ? -19.077 3.510   -2.740  1.00 14.17 ? 277 MET C CB  1 
ATOM   6838 C  CG  . MET C 1 272 ? -20.490 4.063   -2.579  1.00 18.67 ? 277 MET C CG  1 
ATOM   6839 S  SD  . MET C 1 272 ? -21.408 4.352   -4.115  1.00 19.72 ? 277 MET C SD  1 
ATOM   6840 C  CE  . MET C 1 272 ? -22.453 2.911   -4.205  1.00 20.11 ? 277 MET C CE  1 
ATOM   6841 N  N   . TYR C 1 273 ? -16.864 1.259   -3.094  1.00 12.81 ? 278 TYR C N   1 
ATOM   6842 C  CA  . TYR C 1 273 ? -15.436 0.954   -3.268  1.00 12.92 ? 278 TYR C CA  1 
ATOM   6843 C  C   . TYR C 1 273 ? -15.172 0.199   -4.574  1.00 13.32 ? 278 TYR C C   1 
ATOM   6844 O  O   . TYR C 1 273 ? -14.221 0.523   -5.300  1.00 12.79 ? 278 TYR C O   1 
ATOM   6845 C  CB  . TYR C 1 273 ? -14.885 0.175   -2.051  1.00 12.64 ? 278 TYR C CB  1 
ATOM   6846 C  CG  . TYR C 1 273 ? -13.401 0.077   -2.125  1.00 13.38 ? 278 TYR C CG  1 
ATOM   6847 C  CD1 . TYR C 1 273 ? -12.597 1.097   -1.629  1.00 17.27 ? 278 TYR C CD1 1 
ATOM   6848 C  CD2 . TYR C 1 273 ? -12.798 -1.010  -2.747  1.00 15.64 ? 278 TYR C CD2 1 
ATOM   6849 C  CE1 . TYR C 1 273 ? -11.221 1.042   -1.772  1.00 16.64 ? 278 TYR C CE1 1 
ATOM   6850 C  CE2 . TYR C 1 273 ? -11.425 -1.084  -2.861  1.00 16.83 ? 278 TYR C CE2 1 
ATOM   6851 C  CZ  . TYR C 1 273 ? -10.655 -0.048  -2.393  1.00 15.37 ? 278 TYR C CZ  1 
ATOM   6852 O  OH  . TYR C 1 273 ? -9.290  -0.156  -2.510  1.00 19.13 ? 278 TYR C OH  1 
ATOM   6853 N  N   . ILE C 1 274 ? -16.023 -0.788  -4.876  1.00 11.92 ? 279 ILE C N   1 
ATOM   6854 C  CA  . ILE C 1 274 ? -15.937 -1.555  -6.144  1.00 12.20 ? 279 ILE C CA  1 
ATOM   6855 C  C   . ILE C 1 274 ? -15.987 -0.565  -7.341  1.00 13.04 ? 279 ILE C C   1 
ATOM   6856 O  O   . ILE C 1 274 ? -15.122 -0.570  -8.230  1.00 11.10 ? 279 ILE C O   1 
ATOM   6857 C  CB  . ILE C 1 274 ? -17.130 -2.596  -6.268  1.00 11.96 ? 279 ILE C CB  1 
ATOM   6858 C  CG1 . ILE C 1 274 ? -17.021 -3.672  -5.171  1.00 11.26 ? 279 ILE C CG1 1 
ATOM   6859 C  CG2 . ILE C 1 274 ? -17.153 -3.279  -7.679  1.00 10.82 ? 279 ILE C CG2 1 
ATOM   6860 C  CD1 . ILE C 1 274 ? -18.303 -4.626  -5.085  1.00 11.17 ? 279 ILE C CD1 1 
ATOM   6861 N  N   . ALA C 1 275 ? -17.025 0.262   -7.343  1.00 13.98 ? 280 ALA C N   1 
ATOM   6862 C  CA  . ALA C 1 275 ? -17.281 1.240   -8.408  1.00 14.37 ? 280 ALA C CA  1 
ATOM   6863 C  C   . ALA C 1 275 ? -16.107 2.208   -8.592  1.00 15.50 ? 280 ALA C C   1 
ATOM   6864 O  O   . ALA C 1 275 ? -15.645 2.411   -9.741  1.00 14.08 ? 280 ALA C O   1 
ATOM   6865 C  CB  . ALA C 1 275 ? -18.600 1.980   -8.156  1.00 14.53 ? 280 ALA C CB  1 
ATOM   6866 N  N   . GLU C 1 276 ? -15.634 2.778   -7.470  1.00 14.45 ? 281 GLU C N   1 
ATOM   6867 C  CA  . GLU C 1 276 ? -14.485 3.697   -7.451  1.00 15.92 ? 281 GLU C CA  1 
ATOM   6868 C  C   . GLU C 1 276 ? -13.260 3.041   -8.007  1.00 15.35 ? 281 GLU C C   1 
ATOM   6869 O  O   . GLU C 1 276 ? -12.533 3.673   -8.785  1.00 16.35 ? 281 GLU C O   1 
ATOM   6870 C  CB  . GLU C 1 276 ? -14.177 4.160   -6.028  1.00 16.26 ? 281 GLU C CB  1 
ATOM   6871 C  CG  . GLU C 1 276 ? -15.309 4.926   -5.379  1.00 15.38 ? 281 GLU C CG  1 
ATOM   6872 C  CD  . GLU C 1 276 ? -15.061 5.198   -3.886  1.00 17.61 ? 281 GLU C CD  1 
ATOM   6873 O  OE1 . GLU C 1 276 ? -14.202 4.521   -3.239  1.00 15.73 ? 281 GLU C OE1 1 
ATOM   6874 O  OE2 . GLU C 1 276 ? -15.772 6.075   -3.361  1.00 18.58 ? 281 GLU C OE2 1 
ATOM   6875 N  N   . GLU C 1 277 ? -13.022 1.771   -7.649  1.00 14.30 ? 282 GLU C N   1 
ATOM   6876 C  CA  . GLU C 1 277 ? -11.844 1.071   -8.201  1.00 14.53 ? 282 GLU C CA  1 
ATOM   6877 C  C   . GLU C 1 277 ? -12.013 0.797   -9.705  1.00 15.73 ? 282 GLU C C   1 
ATOM   6878 O  O   . GLU C 1 277 ? -11.071 0.909   -10.468 1.00 15.12 ? 282 GLU C O   1 
ATOM   6879 C  CB  . GLU C 1 277 ? -11.549 -0.222  -7.434  1.00 14.78 ? 282 GLU C CB  1 
ATOM   6880 C  CG  . GLU C 1 277 ? -10.959 0.045   -6.066  1.00 17.01 ? 282 GLU C CG  1 
ATOM   6881 C  CD  . GLU C 1 277 ? -9.736  0.961   -6.160  1.00 18.14 ? 282 GLU C CD  1 
ATOM   6882 O  OE1 . GLU C 1 277 ? -8.694  0.514   -6.695  1.00 19.32 ? 282 GLU C OE1 1 
ATOM   6883 O  OE2 . GLU C 1 277 ? -9.839  2.122   -5.734  1.00 19.91 ? 282 GLU C OE2 1 
ATOM   6884 N  N   . ILE C 1 278 ? -13.230 0.484   -10.130 1.00 15.33 ? 283 ILE C N   1 
ATOM   6885 C  CA  . ILE C 1 278 ? -13.488 0.323   -11.558 1.00 17.24 ? 283 ILE C CA  1 
ATOM   6886 C  C   . ILE C 1 278 ? -13.204 1.654   -12.275 1.00 17.60 ? 283 ILE C C   1 
ATOM   6887 O  O   . ILE C 1 278 ? -12.523 1.665   -13.307 1.00 17.71 ? 283 ILE C O   1 
ATOM   6888 C  CB  . ILE C 1 278 ? -14.932 -0.129  -11.822 1.00 16.66 ? 283 ILE C CB  1 
ATOM   6889 C  CG1 . ILE C 1 278 ? -15.141 -1.597  -11.386 1.00 19.46 ? 283 ILE C CG1 1 
ATOM   6890 C  CG2 . ILE C 1 278 ? -15.312 0.066   -13.313 1.00 16.47 ? 283 ILE C CG2 1 
ATOM   6891 C  CD1 . ILE C 1 278 ? -14.596 -2.665  -12.331 1.00 21.43 ? 283 ILE C CD1 1 
ATOM   6892 N  N   . HIS C 1 279 ? -13.708 2.757   -11.729 1.00 17.83 ? 284 HIS C N   1 
ATOM   6893 C  CA  . HIS C 1 279 ? -13.391 4.083   -12.311 1.00 18.86 ? 284 HIS C CA  1 
ATOM   6894 C  C   . HIS C 1 279 ? -11.878 4.304   -12.464 1.00 19.57 ? 284 HIS C C   1 
ATOM   6895 O  O   . HIS C 1 279 ? -11.431 4.704   -13.538 1.00 19.68 ? 284 HIS C O   1 
ATOM   6896 C  CB  . HIS C 1 279 ? -14.015 5.251   -11.518 1.00 19.30 ? 284 HIS C CB  1 
ATOM   6897 C  CG  . HIS C 1 279 ? -13.509 6.596   -11.946 1.00 19.60 ? 284 HIS C CG  1 
ATOM   6898 N  ND1 . HIS C 1 279 ? -13.840 7.164   -13.159 1.00 23.42 ? 284 HIS C ND1 1 
ATOM   6899 C  CD2 . HIS C 1 279 ? -12.672 7.470   -11.343 1.00 23.14 ? 284 HIS C CD2 1 
ATOM   6900 C  CE1 . HIS C 1 279 ? -13.256 8.343   -13.272 1.00 19.72 ? 284 HIS C CE1 1 
ATOM   6901 N  NE2 . HIS C 1 279 ? -12.538 8.551   -12.187 1.00 22.85 ? 284 HIS C NE2 1 
ATOM   6902 N  N   . ASN C 1 280 ? -11.121 4.031   -11.394 1.00 19.57 ? 285 ASN C N   1 
ATOM   6903 C  CA  . ASN C 1 280 ? -9.690  4.341   -11.307 1.00 21.26 ? 285 ASN C CA  1 
ATOM   6904 C  C   . ASN C 1 280 ? -8.836  3.570   -12.315 1.00 21.28 ? 285 ASN C C   1 
ATOM   6905 O  O   . ASN C 1 280 ? -7.688  3.948   -12.572 1.00 21.94 ? 285 ASN C O   1 
ATOM   6906 C  CB  . ASN C 1 280 ? -9.158  4.085   -9.894  1.00 21.97 ? 285 ASN C CB  1 
ATOM   6907 C  CG  . ASN C 1 280 ? -9.698  5.084   -8.861  1.00 24.17 ? 285 ASN C CG  1 
ATOM   6908 O  OD1 . ASN C 1 280 ? -10.296 6.101   -9.211  1.00 24.64 ? 285 ASN C OD1 1 
ATOM   6909 N  ND2 . ASN C 1 280 ? -9.481  4.786   -7.583  1.00 23.34 ? 285 ASN C ND2 1 
ATOM   6910 N  N   . THR C 1 281 ? -9.372  2.483   -12.862 1.00 20.55 ? 286 THR C N   1 
ATOM   6911 C  CA  . THR C 1 281 ? -8.650  1.761   -13.935 1.00 19.97 ? 286 THR C CA  1 
ATOM   6912 C  C   . THR C 1 281 ? -8.545  2.604   -15.208 1.00 19.88 ? 286 THR C C   1 
ATOM   6913 O  O   . THR C 1 281 ? -7.569  2.450   -15.947 1.00 20.60 ? 286 THR C O   1 
ATOM   6914 C  CB  . THR C 1 281 ? -9.281  0.417   -14.322 1.00 18.98 ? 286 THR C CB  1 
ATOM   6915 O  OG1 . THR C 1 281 ? -10.537 0.649   -14.953 1.00 17.84 ? 286 THR C OG1 1 
ATOM   6916 C  CG2 . THR C 1 281 ? -9.476  -0.507  -13.092 1.00 20.34 ? 286 THR C CG2 1 
ATOM   6917 N  N   . GLY C 1 282 ? -9.526  3.483   -15.434 1.00 19.20 ? 287 GLY C N   1 
ATOM   6918 C  CA  . GLY C 1 282 ? -9.673  4.230   -16.701 1.00 19.74 ? 287 GLY C CA  1 
ATOM   6919 C  C   . GLY C 1 282 ? -10.077 3.317   -17.872 1.00 19.95 ? 287 GLY C C   1 
ATOM   6920 O  O   . GLY C 1 282 ? -9.963  3.706   -19.049 1.00 18.87 ? 287 GLY C O   1 
ATOM   6921 N  N   . LEU C 1 283 ? -10.572 2.113   -17.556 1.00 18.56 ? 288 LEU C N   1 
ATOM   6922 C  CA  . LEU C 1 283 ? -10.851 1.091   -18.563 1.00 18.89 ? 288 LEU C CA  1 
ATOM   6923 C  C   . LEU C 1 283 ? -12.299 0.694   -18.664 1.00 18.57 ? 288 LEU C C   1 
ATOM   6924 O  O   . LEU C 1 283 ? -12.649 -0.185  -19.451 1.00 18.80 ? 288 LEU C O   1 
ATOM   6925 C  CB  . LEU C 1 283 ? -9.987  -0.162  -18.321 1.00 18.62 ? 288 LEU C CB  1 
ATOM   6926 C  CG  . LEU C 1 283 ? -8.504  0.074   -18.642 1.00 19.15 ? 288 LEU C CG  1 
ATOM   6927 C  CD1 . LEU C 1 283 ? -7.645  -1.100  -18.129 1.00 19.92 ? 288 LEU C CD1 1 
ATOM   6928 C  CD2 . LEU C 1 283 ? -8.271  0.334   -20.156 1.00 18.00 ? 288 LEU C CD2 1 
ATOM   6929 N  N   . LEU C 1 284 ? -13.154 1.354   -17.899 1.00 18.58 ? 289 LEU C N   1 
ATOM   6930 C  CA  . LEU C 1 284 ? -14.583 1.061   -17.969 1.00 18.84 ? 289 LEU C CA  1 
ATOM   6931 C  C   . LEU C 1 284 ? -15.202 1.358   -19.339 1.00 19.34 ? 289 LEU C C   1 
ATOM   6932 O  O   . LEU C 1 284 ? -15.262 2.510   -19.780 1.00 18.61 ? 289 LEU C O   1 
ATOM   6933 C  CB  . LEU C 1 284 ? -15.339 1.813   -16.884 1.00 19.25 ? 289 LEU C CB  1 
ATOM   6934 C  CG  . LEU C 1 284 ? -16.822 1.442   -16.860 1.00 19.40 ? 289 LEU C CG  1 
ATOM   6935 C  CD1 . LEU C 1 284 ? -17.009 -0.064  -16.531 1.00 20.10 ? 289 LEU C CD1 1 
ATOM   6936 C  CD2 . LEU C 1 284 ? -17.542 2.343   -15.847 1.00 18.93 ? 289 LEU C CD2 1 
ATOM   6937 N  N   . SER C 1 285 ? -15.693 0.317   -19.990 1.00 19.00 ? 290 SER C N   1 
ATOM   6938 C  CA  . SER C 1 285 ? -16.190 0.447   -21.354 1.00 19.72 ? 290 SER C CA  1 
ATOM   6939 C  C   . SER C 1 285 ? -17.712 0.253   -21.465 1.00 19.88 ? 290 SER C C   1 
ATOM   6940 O  O   . SER C 1 285 ? -18.356 0.883   -22.308 1.00 20.83 ? 290 SER C O   1 
ATOM   6941 C  CB  . SER C 1 285 ? -15.387 -0.474  -22.284 1.00 19.60 ? 290 SER C CB  1 
ATOM   6942 O  OG  . SER C 1 285 ? -15.950 -0.558  -23.588 1.00 21.06 ? 290 SER C OG  1 
ATOM   6943 N  N   . ALA C 1 286 ? -18.285 -0.634  -20.657 1.00 18.44 ? 291 ALA C N   1 
ATOM   6944 C  CA  . ALA C 1 286 ? -19.758 -0.744  -20.534 1.00 17.96 ? 291 ALA C CA  1 
ATOM   6945 C  C   . ALA C 1 286 ? -20.141 -1.116  -19.101 1.00 17.78 ? 291 ALA C C   1 
ATOM   6946 O  O   . ALA C 1 286 ? -19.351 -1.750  -18.388 1.00 16.60 ? 291 ALA C O   1 
ATOM   6947 C  CB  . ALA C 1 286 ? -20.317 -1.781  -21.507 1.00 17.41 ? 291 ALA C CB  1 
ATOM   6948 N  N   . LEU C 1 287 ? -21.346 -0.749  -18.688 1.00 17.34 ? 292 LEU C N   1 
ATOM   6949 C  CA  . LEU C 1 287 ? -21.830 -1.099  -17.361 1.00 17.98 ? 292 LEU C CA  1 
ATOM   6950 C  C   . LEU C 1 287 ? -23.311 -1.488  -17.448 1.00 17.91 ? 292 LEU C C   1 
ATOM   6951 O  O   . LEU C 1 287 ? -24.077 -0.771  -18.064 1.00 18.34 ? 292 LEU C O   1 
ATOM   6952 C  CB  . LEU C 1 287 ? -21.661 0.119   -16.440 1.00 18.51 ? 292 LEU C CB  1 
ATOM   6953 C  CG  . LEU C 1 287 ? -22.164 0.099   -14.985 1.00 19.80 ? 292 LEU C CG  1 
ATOM   6954 C  CD1 . LEU C 1 287 ? -21.502 1.252   -14.227 1.00 21.82 ? 292 LEU C CD1 1 
ATOM   6955 C  CD2 . LEU C 1 287 ? -23.644 0.291   -14.895 1.00 21.89 ? 292 LEU C CD2 1 
ATOM   6956 N  N   . ASP C 1 288 ? -23.716 -2.603  -16.848 1.00 17.65 ? 293 ASP C N   1 
ATOM   6957 C  CA  . ASP C 1 288 ? -25.158 -2.914  -16.708 1.00 17.28 ? 293 ASP C CA  1 
ATOM   6958 C  C   . ASP C 1 288 ? -25.558 -2.631  -15.258 1.00 17.86 ? 293 ASP C C   1 
ATOM   6959 O  O   . ASP C 1 288 ? -24.791 -2.956  -14.336 1.00 17.80 ? 293 ASP C O   1 
ATOM   6960 C  CB  . ASP C 1 288 ? -25.423 -4.394  -16.994 1.00 17.77 ? 293 ASP C CB  1 
ATOM   6961 C  CG  . ASP C 1 288 ? -24.707 -4.906  -18.235 1.00 17.89 ? 293 ASP C CG  1 
ATOM   6962 O  OD1 . ASP C 1 288 ? -24.717 -4.201  -19.253 1.00 20.12 ? 293 ASP C OD1 1 
ATOM   6963 O  OD2 . ASP C 1 288 ? -24.156 -6.035  -18.211 1.00 19.66 ? 293 ASP C OD2 1 
ATOM   6964 N  N   . LEU C 1 289 ? -26.713 -1.993  -15.046 1.00 17.01 ? 294 LEU C N   1 
ATOM   6965 C  CA  . LEU C 1 289 ? -27.259 -1.852  -13.692 1.00 16.22 ? 294 LEU C CA  1 
ATOM   6966 C  C   . LEU C 1 289 ? -28.627 -2.501  -13.740 1.00 17.14 ? 294 LEU C C   1 
ATOM   6967 O  O   . LEU C 1 289 ? -29.582 -1.909  -14.259 1.00 16.19 ? 294 LEU C O   1 
ATOM   6968 C  CB  . LEU C 1 289 ? -27.335 -0.388  -13.240 1.00 15.20 ? 294 LEU C CB  1 
ATOM   6969 C  CG  . LEU C 1 289 ? -27.452 -0.163  -11.714 1.00 17.41 ? 294 LEU C CG  1 
ATOM   6970 C  CD1 . LEU C 1 289 ? -28.644 -0.904  -11.181 1.00 16.28 ? 294 LEU C CD1 1 
ATOM   6971 C  CD2 . LEU C 1 289 ? -26.158 -0.604  -10.987 1.00 17.68 ? 294 LEU C CD2 1 
ATOM   6972 N  N   . VAL C 1 290 ? -28.702 -3.720  -13.229 1.00 16.68 ? 295 VAL C N   1 
ATOM   6973 C  CA  . VAL C 1 290 ? -29.878 -4.548  -13.442 1.00 18.05 ? 295 VAL C CA  1 
ATOM   6974 C  C   . VAL C 1 290 ? -30.623 -4.912  -12.146 1.00 18.73 ? 295 VAL C C   1 
ATOM   6975 O  O   . VAL C 1 290 ? -30.102 -4.747  -11.035 1.00 17.85 ? 295 VAL C O   1 
ATOM   6976 C  CB  . VAL C 1 290 ? -29.537 -5.851  -14.248 1.00 17.72 ? 295 VAL C CB  1 
ATOM   6977 C  CG1 . VAL C 1 290 ? -28.897 -5.517  -15.622 1.00 18.99 ? 295 VAL C CG1 1 
ATOM   6978 C  CG2 . VAL C 1 290 ? -28.646 -6.803  -13.413 1.00 17.19 ? 295 VAL C CG2 1 
ATOM   6979 N  N   . GLU C 1 291 ? -31.866 -5.374  -12.327 1.00 19.36 ? 296 GLU C N   1 
ATOM   6980 C  CA  . GLU C 1 291 ? -32.694 -6.024  -11.280 1.00 18.87 ? 296 GLU C CA  1 
ATOM   6981 C  C   . GLU C 1 291 ? -33.402 -5.117  -10.265 1.00 19.48 ? 296 GLU C C   1 
ATOM   6982 O  O   . GLU C 1 291 ? -33.954 -5.610  -9.274  1.00 19.31 ? 296 GLU C O   1 
ATOM   6983 C  CB  . GLU C 1 291 ? -31.951 -7.198  -10.589 1.00 18.94 ? 296 GLU C CB  1 
ATOM   6984 C  CG  . GLU C 1 291 ? -31.542 -8.386  -11.513 1.00 18.06 ? 296 GLU C CG  1 
ATOM   6985 C  CD  . GLU C 1 291 ? -32.694 -9.303  -11.944 1.00 22.36 ? 296 GLU C CD  1 
ATOM   6986 O  OE1 . GLU C 1 291 ? -33.850 -9.110  -11.457 1.00 26.14 ? 296 GLU C OE1 1 
ATOM   6987 O  OE2 . GLU C 1 291 ? -32.442 -10.244 -12.757 1.00 21.31 ? 296 GLU C OE2 1 
ATOM   6988 N  N   . VAL C 1 292 ? -33.386 -3.805  -10.498 1.00 20.08 ? 297 VAL C N   1 
ATOM   6989 C  CA  . VAL C 1 292 ? -34.170 -2.877  -9.681  1.00 21.10 ? 297 VAL C CA  1 
ATOM   6990 C  C   . VAL C 1 292 ? -35.639 -3.089  -10.075 1.00 22.05 ? 297 VAL C C   1 
ATOM   6991 O  O   . VAL C 1 292 ? -35.982 -2.945  -11.241 1.00 22.62 ? 297 VAL C O   1 
ATOM   6992 C  CB  . VAL C 1 292 ? -33.770 -1.400  -9.889  1.00 20.30 ? 297 VAL C CB  1 
ATOM   6993 C  CG1 . VAL C 1 292 ? -34.796 -0.455  -9.186  1.00 20.44 ? 297 VAL C CG1 1 
ATOM   6994 C  CG2 . VAL C 1 292 ? -32.355 -1.115  -9.339  1.00 20.09 ? 297 VAL C CG2 1 
ATOM   6995 N  N   . ASN C 1 293 ? -36.456 -3.496  -9.107  1.00 23.58 ? 298 ASN C N   1 
ATOM   6996 C  CA  . ASN C 1 293 ? -37.896 -3.716  -9.286  1.00 24.79 ? 298 ASN C CA  1 
ATOM   6997 C  C   . ASN C 1 293 ? -38.629 -2.919  -8.194  1.00 26.34 ? 298 ASN C C   1 
ATOM   6998 O  O   . ASN C 1 293 ? -38.865 -3.434  -7.096  1.00 26.53 ? 298 ASN C O   1 
ATOM   6999 C  CB  . ASN C 1 293 ? -38.219 -5.222  -9.218  1.00 25.14 ? 298 ASN C CB  1 
ATOM   7000 C  CG  . ASN C 1 293 ? -39.691 -5.550  -9.571  1.00 24.66 ? 298 ASN C CG  1 
ATOM   7001 O  OD1 . ASN C 1 293 ? -40.551 -4.674  -9.584  1.00 23.95 ? 298 ASN C OD1 1 
ATOM   7002 N  ND2 . ASN C 1 293 ? -39.961 -6.815  -9.871  1.00 22.84 ? 298 ASN C ND2 1 
ATOM   7003 N  N   . PRO C 1 294 ? -38.966 -1.649  -8.487  1.00 27.26 ? 299 PRO C N   1 
ATOM   7004 C  CA  . PRO C 1 294 ? -39.667 -0.732  -7.570  1.00 29.28 ? 299 PRO C CA  1 
ATOM   7005 C  C   . PRO C 1 294 ? -41.032 -1.254  -7.087  1.00 30.36 ? 299 PRO C C   1 
ATOM   7006 O  O   . PRO C 1 294 ? -41.475 -0.898  -6.004  1.00 30.88 ? 299 PRO C O   1 
ATOM   7007 C  CB  . PRO C 1 294 ? -39.843 0.546   -8.405  1.00 28.81 ? 299 PRO C CB  1 
ATOM   7008 C  CG  . PRO C 1 294 ? -39.696 0.098   -9.832  1.00 28.95 ? 299 PRO C CG  1 
ATOM   7009 C  CD  . PRO C 1 294 ? -38.700 -1.018  -9.793  1.00 27.88 ? 299 PRO C CD  1 
ATOM   7010 N  N   . GLN C 1 295 ? -41.660 -2.121  -7.868  1.00 32.48 ? 300 GLN C N   1 
ATOM   7011 C  CA  . GLN C 1 295 ? -42.937 -2.721  -7.490  1.00 33.92 ? 300 GLN C CA  1 
ATOM   7012 C  C   . GLN C 1 295 ? -42.818 -3.738  -6.353  1.00 34.69 ? 300 GLN C C   1 
ATOM   7013 O  O   . GLN C 1 295 ? -43.824 -4.127  -5.740  1.00 34.62 ? 300 GLN C O   1 
ATOM   7014 C  CB  . GLN C 1 295 ? -43.577 -3.372  -8.700  1.00 34.04 ? 300 GLN C CB  1 
ATOM   7015 C  CG  . GLN C 1 295 ? -44.108 -2.367  -9.705  1.00 37.25 ? 300 GLN C CG  1 
ATOM   7016 C  CD  . GLN C 1 295 ? -44.939 -3.022  -10.791 1.00 39.10 ? 300 GLN C CD  1 
ATOM   7017 O  OE1 . GLN C 1 295 ? -45.393 -4.149  -10.648 1.00 41.59 ? 300 GLN C OE1 1 
ATOM   7018 N  NE2 . GLN C 1 295 ? -45.148 -2.309  -11.878 1.00 42.32 ? 300 GLN C NE2 1 
ATOM   7019 N  N   . LEU C 1 296 ? -41.596 -4.190  -6.081  1.00 35.41 ? 301 LEU C N   1 
ATOM   7020 C  CA  . LEU C 1 296 ? -41.382 -5.134  -4.997  1.00 35.86 ? 301 LEU C CA  1 
ATOM   7021 C  C   . LEU C 1 296 ? -41.048 -4.466  -3.670  1.00 36.50 ? 301 LEU C C   1 
ATOM   7022 O  O   . LEU C 1 296 ? -40.951 -5.145  -2.642  1.00 37.10 ? 301 LEU C O   1 
ATOM   7023 C  CB  . LEU C 1 296 ? -40.319 -6.176  -5.367  1.00 35.73 ? 301 LEU C CB  1 
ATOM   7024 C  CG  . LEU C 1 296 ? -40.730 -7.192  -6.432  1.00 35.98 ? 301 LEU C CG  1 
ATOM   7025 C  CD1 . LEU C 1 296 ? -39.543 -8.067  -6.744  1.00 36.77 ? 301 LEU C CD1 1 
ATOM   7026 C  CD2 . LEU C 1 296 ? -41.920 -8.053  -5.969  1.00 36.54 ? 301 LEU C CD2 1 
ATOM   7027 N  N   . ALA C 1 297 ? -40.861 -3.151  -3.693  1.00 36.82 ? 302 ALA C N   1 
ATOM   7028 C  CA  . ALA C 1 297 ? -40.668 -2.381  -2.466  1.00 38.17 ? 302 ALA C CA  1 
ATOM   7029 C  C   . ALA C 1 297 ? -41.966 -2.389  -1.627  1.00 39.09 ? 302 ALA C C   1 
ATOM   7030 O  O   . ALA C 1 297 ? -43.062 -2.397  -2.199  1.00 39.07 ? 302 ALA C O   1 
ATOM   7031 C  CB  . ALA C 1 297 ? -40.281 -0.965  -2.809  1.00 37.61 ? 302 ALA C CB  1 
ATOM   7032 N  N   . THR C 1 298 ? -41.835 -2.393  -0.298  1.00 39.94 ? 303 THR C N   1 
ATOM   7033 C  CA  . THR C 1 298 ? -42.998 -2.336  0.612   1.00 41.39 ? 303 THR C CA  1 
ATOM   7034 C  C   . THR C 1 298 ? -43.413 -0.897  0.919   1.00 41.70 ? 303 THR C C   1 
ATOM   7035 O  O   . THR C 1 298 ? -44.396 -0.669  1.630   1.00 42.80 ? 303 THR C O   1 
ATOM   7036 C  CB  . THR C 1 298 ? -42.748 -3.067  1.962   1.00 41.16 ? 303 THR C CB  1 
ATOM   7037 O  OG1 . THR C 1 298 ? -41.594 -2.505  2.599   1.00 42.98 ? 303 THR C OG1 1 
ATOM   7038 C  CG2 . THR C 1 298 ? -42.547 -4.563  1.760   1.00 42.03 ? 303 THR C CG2 1 
ATOM   7039 N  N   . SER C 1 299 ? -42.660 0.061   0.390   1.00 41.96 ? 304 SER C N   1 
ATOM   7040 C  CA  . SER C 1 299 ? -42.943 1.475   0.566   1.00 42.29 ? 304 SER C CA  1 
ATOM   7041 C  C   . SER C 1 299 ? -42.312 2.272   -0.566  1.00 42.82 ? 304 SER C C   1 
ATOM   7042 O  O   . SER C 1 299 ? -41.410 1.784   -1.261  1.00 42.77 ? 304 SER C O   1 
ATOM   7043 C  CB  . SER C 1 299 ? -42.400 1.967   1.909   1.00 42.38 ? 304 SER C CB  1 
ATOM   7044 O  OG  . SER C 1 299 ? -40.984 1.900   1.960   1.00 40.61 ? 304 SER C OG  1 
ATOM   7045 N  N   . GLU C 1 300 ? -42.772 3.508   -0.729  1.00 42.84 ? 305 GLU C N   1 
ATOM   7046 C  CA  . GLU C 1 300 ? -42.188 4.424   -1.695  1.00 42.87 ? 305 GLU C CA  1 
ATOM   7047 C  C   . GLU C 1 300 ? -40.708 4.680   -1.406  1.00 42.30 ? 305 GLU C C   1 
ATOM   7048 O  O   . GLU C 1 300 ? -39.901 4.719   -2.331  1.00 42.13 ? 305 GLU C O   1 
ATOM   7049 C  CB  . GLU C 1 300 ? -42.960 5.742   -1.723  1.00 43.41 ? 305 GLU C CB  1 
ATOM   7050 C  CG  . GLU C 1 300 ? -42.415 6.777   -2.700  1.00 45.95 ? 305 GLU C CG  1 
ATOM   7051 C  CD  . GLU C 1 300 ? -43.515 7.604   -3.338  1.00 50.19 ? 305 GLU C CD  1 
ATOM   7052 O  OE1 . GLU C 1 300 ? -44.684 7.145   -3.344  1.00 52.21 ? 305 GLU C OE1 1 
ATOM   7053 O  OE2 . GLU C 1 300 ? -43.213 8.706   -3.847  1.00 51.21 ? 305 GLU C OE2 1 
ATOM   7054 N  N   . GLU C 1 301 ? -40.358 4.859   -0.135  1.00 41.39 ? 306 GLU C N   1 
ATOM   7055 C  CA  . GLU C 1 301 ? -38.973 5.146   0.206   1.00 40.55 ? 306 GLU C CA  1 
ATOM   7056 C  C   . GLU C 1 301 ? -38.055 3.932   0.033   1.00 38.88 ? 306 GLU C C   1 
ATOM   7057 O  O   . GLU C 1 301 ? -36.904 4.118   -0.306  1.00 38.81 ? 306 GLU C O   1 
ATOM   7058 C  CB  . GLU C 1 301 ? -38.816 5.818   1.582   1.00 41.24 ? 306 GLU C CB  1 
ATOM   7059 C  CG  . GLU C 1 301 ? -39.063 4.933   2.801   1.00 44.48 ? 306 GLU C CG  1 
ATOM   7060 C  CD  . GLU C 1 301 ? -38.518 5.544   4.106   1.00 48.47 ? 306 GLU C CD  1 
ATOM   7061 O  OE1 . GLU C 1 301 ? -38.393 6.787   4.189   1.00 50.69 ? 306 GLU C OE1 1 
ATOM   7062 O  OE2 . GLU C 1 301 ? -38.214 4.773   5.049   1.00 48.99 ? 306 GLU C OE2 1 
ATOM   7063 N  N   . GLU C 1 302 ? -38.557 2.712   0.259   1.00 37.35 ? 307 GLU C N   1 
ATOM   7064 C  CA  . GLU C 1 302 ? -37.836 1.482   -0.145  1.00 36.32 ? 307 GLU C CA  1 
ATOM   7065 C  C   . GLU C 1 302 ? -37.495 1.486   -1.656  1.00 35.40 ? 307 GLU C C   1 
ATOM   7066 O  O   . GLU C 1 302 ? -36.351 1.191   -2.048  1.00 34.71 ? 307 GLU C O   1 
ATOM   7067 C  CB  . GLU C 1 302 ? -38.606 0.197   0.213   1.00 36.35 ? 307 GLU C CB  1 
ATOM   7068 C  CG  . GLU C 1 302 ? -38.361 -0.353  1.618   1.00 36.69 ? 307 GLU C CG  1 
ATOM   7069 C  CD  . GLU C 1 302 ? -38.786 -1.824  1.788   1.00 38.82 ? 307 GLU C CD  1 
ATOM   7070 O  OE1 . GLU C 1 302 ? -39.150 -2.519  0.801   1.00 38.46 ? 307 GLU C OE1 1 
ATOM   7071 O  OE2 . GLU C 1 302 ? -38.766 -2.294  2.936   1.00 40.87 ? 307 GLU C OE2 1 
ATOM   7072 N  N   . ALA C 1 303 ? -38.480 1.822   -2.496  1.00 33.69 ? 308 ALA C N   1 
ATOM   7073 C  CA  . ALA C 1 303 ? -38.258 1.906   -3.954  1.00 32.59 ? 308 ALA C CA  1 
ATOM   7074 C  C   . ALA C 1 303 ? -37.249 3.000   -4.290  1.00 32.03 ? 308 ALA C C   1 
ATOM   7075 O  O   . ALA C 1 303 ? -36.281 2.747   -5.004  1.00 31.95 ? 308 ALA C O   1 
ATOM   7076 C  CB  . ALA C 1 303 ? -39.564 2.146   -4.698  1.00 32.33 ? 308 ALA C CB  1 
ATOM   7077 N  N   . LYS C 1 304 ? -37.476 4.211   -3.764  1.00 31.42 ? 309 LYS C N   1 
ATOM   7078 C  CA  . LYS C 1 304 ? -36.550 5.337   -3.961  1.00 30.48 ? 309 LYS C CA  1 
ATOM   7079 C  C   . LYS C 1 304 ? -35.109 5.090   -3.422  1.00 29.30 ? 309 LYS C C   1 
ATOM   7080 O  O   . LYS C 1 304 ? -34.144 5.478   -4.063  1.00 28.86 ? 309 LYS C O   1 
ATOM   7081 C  CB  . LYS C 1 304 ? -37.115 6.650   -3.404  1.00 30.23 ? 309 LYS C CB  1 
ATOM   7082 C  CG  . LYS C 1 304 ? -38.311 7.205   -4.180  1.00 33.98 ? 309 LYS C CG  1 
ATOM   7083 C  CD  . LYS C 1 304 ? -38.650 8.644   -3.749  1.00 38.30 ? 309 LYS C CD  1 
ATOM   7084 C  CE  . LYS C 1 304 ? -39.961 9.106   -4.388  1.00 41.81 ? 309 LYS C CE  1 
ATOM   7085 N  NZ  . LYS C 1 304 ? -40.684 10.107  -3.533  1.00 42.23 ? 309 LYS C NZ  1 
ATOM   7086 N  N   . THR C 1 305 ? -34.962 4.460   -2.262  1.00 28.15 ? 310 THR C N   1 
ATOM   7087 C  CA  . THR C 1 305 ? -33.605 4.201   -1.744  1.00 27.81 ? 310 THR C CA  1 
ATOM   7088 C  C   . THR C 1 305 ? -32.833 3.262   -2.707  1.00 26.16 ? 310 THR C C   1 
ATOM   7089 O  O   . THR C 1 305 ? -31.644 3.470   -2.974  1.00 25.93 ? 310 THR C O   1 
ATOM   7090 C  CB  . THR C 1 305 ? -33.611 3.708   -0.255  1.00 28.19 ? 310 THR C CB  1 
ATOM   7091 O  OG1 . THR C 1 305 ? -32.295 3.786   0.291   1.00 29.94 ? 310 THR C OG1 1 
ATOM   7092 C  CG2 . THR C 1 305 ? -34.082 2.296   -0.114  1.00 28.78 ? 310 THR C CG2 1 
ATOM   7093 N  N   . THR C 1 306 ? -33.536 2.283   -3.263  1.00 25.66 ? 311 THR C N   1 
ATOM   7094 C  CA  . THR C 1 306 ? -32.927 1.322   -4.189  1.00 23.60 ? 311 THR C CA  1 
ATOM   7095 C  C   . THR C 1 306 ? -32.466 2.008   -5.476  1.00 23.26 ? 311 THR C C   1 
ATOM   7096 O  O   . THR C 1 306 ? -31.349 1.755   -5.956  1.00 23.01 ? 311 THR C O   1 
ATOM   7097 C  CB  . THR C 1 306 ? -33.860 0.151   -4.491  1.00 23.74 ? 311 THR C CB  1 
ATOM   7098 O  OG1 . THR C 1 306 ? -34.296 -0.442  -3.260  1.00 21.91 ? 311 THR C OG1 1 
ATOM   7099 C  CG2 . THR C 1 306 ? -33.113 -0.917  -5.351  1.00 22.09 ? 311 THR C CG2 1 
ATOM   7100 N  N   . ALA C 1 307 ? -33.316 2.881   -6.018  1.00 22.18 ? 312 ALA C N   1 
ATOM   7101 C  CA  . ALA C 1 307 ? -32.982 3.681   -7.196  1.00 21.10 ? 312 ALA C CA  1 
ATOM   7102 C  C   . ALA C 1 307 ? -31.852 4.644   -6.929  1.00 21.07 ? 312 ALA C C   1 
ATOM   7103 O  O   . ALA C 1 307 ? -30.980 4.823   -7.785  1.00 20.09 ? 312 ALA C O   1 
ATOM   7104 C  CB  . ALA C 1 307 ? -34.226 4.452   -7.719  1.00 22.11 ? 312 ALA C CB  1 
ATOM   7105 N  N   . ASN C 1 308 ? -31.873 5.294   -5.758  1.00 20.10 ? 313 ASN C N   1 
ATOM   7106 C  CA  . ASN C 1 308 ? -30.799 6.202   -5.385  1.00 19.79 ? 313 ASN C CA  1 
ATOM   7107 C  C   . ASN C 1 308 ? -29.435 5.481   -5.299  1.00 18.56 ? 313 ASN C C   1 
ATOM   7108 O  O   . ASN C 1 308 ? -28.419 6.015   -5.722  1.00 17.89 ? 313 ASN C O   1 
ATOM   7109 C  CB  . ASN C 1 308 ? -31.116 6.876   -4.055  1.00 20.34 ? 313 ASN C CB  1 
ATOM   7110 C  CG  . ASN C 1 308 ? -32.227 7.928   -4.187  1.00 24.17 ? 313 ASN C CG  1 
ATOM   7111 O  OD1 . ASN C 1 308 ? -32.481 8.442   -5.283  1.00 25.24 ? 313 ASN C OD1 1 
ATOM   7112 N  ND2 . ASN C 1 308 ? -32.866 8.257   -3.071  1.00 23.88 ? 313 ASN C ND2 1 
ATOM   7113 N  N   . LEU C 1 309 ? -29.450 4.298   -4.698  1.00 18.16 ? 314 LEU C N   1 
ATOM   7114 C  CA  . LEU C 1 309 ? -28.284 3.433   -4.646  1.00 18.27 ? 314 LEU C CA  1 
ATOM   7115 C  C   . LEU C 1 309 ? -27.781 3.051   -6.050  1.00 18.10 ? 314 LEU C C   1 
ATOM   7116 O  O   . LEU C 1 309 ? -26.571 3.082   -6.299  1.00 17.42 ? 314 LEU C O   1 
ATOM   7117 C  CB  . LEU C 1 309 ? -28.590 2.187   -3.819  1.00 17.43 ? 314 LEU C CB  1 
ATOM   7118 C  CG  . LEU C 1 309 ? -27.488 1.156   -3.608  1.00 16.98 ? 314 LEU C CG  1 
ATOM   7119 C  CD1 . LEU C 1 309 ? -26.271 1.810   -2.891  1.00 19.87 ? 314 LEU C CD1 1 
ATOM   7120 C  CD2 . LEU C 1 309 ? -28.069 -0.007  -2.845  1.00 15.16 ? 314 LEU C CD2 1 
ATOM   7121 N  N   . ALA C 1 310 ? -28.700 2.674   -6.946  1.00 18.08 ? 315 ALA C N   1 
ATOM   7122 C  CA  . ALA C 1 310 ? -28.349 2.448   -8.347  1.00 18.00 ? 315 ALA C CA  1 
ATOM   7123 C  C   . ALA C 1 310 ? -27.614 3.644   -8.943  1.00 18.55 ? 315 ALA C C   1 
ATOM   7124 O  O   . ALA C 1 310 ? -26.587 3.489   -9.599  1.00 16.57 ? 315 ALA C O   1 
ATOM   7125 C  CB  . ALA C 1 310 ? -29.638 2.090   -9.207  1.00 19.26 ? 315 ALA C CB  1 
ATOM   7126 N  N   . VAL C 1 311 ? -28.129 4.856   -8.710  1.00 19.22 ? 316 VAL C N   1 
ATOM   7127 C  CA  . VAL C 1 311 ? -27.453 6.048   -9.218  1.00 18.51 ? 316 VAL C CA  1 
ATOM   7128 C  C   . VAL C 1 311 ? -26.065 6.253   -8.642  1.00 17.98 ? 316 VAL C C   1 
ATOM   7129 O  O   . VAL C 1 311 ? -25.138 6.593   -9.372  1.00 18.18 ? 316 VAL C O   1 
ATOM   7130 C  CB  . VAL C 1 311 ? -28.320 7.318   -9.032  1.00 18.99 ? 316 VAL C CB  1 
ATOM   7131 C  CG1 . VAL C 1 311 ? -27.544 8.539   -9.505  1.00 19.92 ? 316 VAL C CG1 1 
ATOM   7132 C  CG2 . VAL C 1 311 ? -29.612 7.133   -9.766  1.00 19.38 ? 316 VAL C CG2 1 
ATOM   7133 N  N   . ASP C 1 312 ? -25.905 6.027   -7.340  1.00 17.57 ? 317 ASP C N   1 
ATOM   7134 C  CA  . ASP C 1 312 ? -24.581 6.108   -6.735  1.00 18.11 ? 317 ASP C CA  1 
ATOM   7135 C  C   . ASP C 1 312 ? -23.582 5.135   -7.367  1.00 17.18 ? 317 ASP C C   1 
ATOM   7136 O  O   . ASP C 1 312 ? -22.420 5.496   -7.542  1.00 17.29 ? 317 ASP C O   1 
ATOM   7137 C  CB  . ASP C 1 312 ? -24.660 5.854   -5.220  1.00 17.68 ? 317 ASP C CB  1 
ATOM   7138 C  CG  . ASP C 1 312 ? -25.182 7.055   -4.448  1.00 20.41 ? 317 ASP C CG  1 
ATOM   7139 O  OD1 . ASP C 1 312 ? -25.269 8.176   -5.022  1.00 22.29 ? 317 ASP C OD1 1 
ATOM   7140 O  OD2 . ASP C 1 312 ? -25.461 6.891   -3.255  1.00 19.75 ? 317 ASP C OD2 1 
ATOM   7141 N  N   . VAL C 1 313 ? -24.018 3.902   -7.655  1.00 17.01 ? 318 VAL C N   1 
ATOM   7142 C  CA  . VAL C 1 313 ? -23.108 2.899   -8.272  1.00 16.84 ? 318 VAL C CA  1 
ATOM   7143 C  C   . VAL C 1 313 ? -22.622 3.440   -9.634  1.00 17.50 ? 318 VAL C C   1 
ATOM   7144 O  O   . VAL C 1 313 ? -21.408 3.485   -9.906  1.00 16.41 ? 318 VAL C O   1 
ATOM   7145 C  CB  . VAL C 1 313 ? -23.796 1.535   -8.475  1.00 18.09 ? 318 VAL C CB  1 
ATOM   7146 C  CG1 . VAL C 1 313 ? -22.906 0.571   -9.328  1.00 17.16 ? 318 VAL C CG1 1 
ATOM   7147 C  CG2 . VAL C 1 313 ? -24.167 0.887   -7.096  1.00 17.10 ? 318 VAL C CG2 1 
ATOM   7148 N  N   . ILE C 1 314 ? -23.575 3.856   -10.467 1.00 17.39 ? 319 ILE C N   1 
ATOM   7149 C  CA  . ILE C 1 314 ? -23.270 4.360   -11.820 1.00 17.92 ? 319 ILE C CA  1 
ATOM   7150 C  C   . ILE C 1 314 ? -22.404 5.608   -11.748 1.00 18.43 ? 319 ILE C C   1 
ATOM   7151 O  O   . ILE C 1 314 ? -21.400 5.686   -12.435 1.00 19.17 ? 319 ILE C O   1 
ATOM   7152 C  CB  . ILE C 1 314 ? -24.539 4.592   -12.725 1.00 18.02 ? 319 ILE C CB  1 
ATOM   7153 C  CG1 . ILE C 1 314 ? -25.400 3.328   -12.805 1.00 15.87 ? 319 ILE C CG1 1 
ATOM   7154 C  CG2 . ILE C 1 314 ? -24.103 5.061   -14.159 1.00 16.06 ? 319 ILE C CG2 1 
ATOM   7155 C  CD1 . ILE C 1 314 ? -26.836 3.572   -13.213 1.00 16.43 ? 319 ILE C CD1 1 
ATOM   7156 N  N   . ALA C 1 315 ? -22.756 6.567   -10.889 1.00 19.26 ? 320 ALA C N   1 
ATOM   7157 C  CA  . ALA C 1 315 ? -21.975 7.806   -10.763 1.00 19.14 ? 320 ALA C CA  1 
ATOM   7158 C  C   . ALA C 1 315 ? -20.554 7.542   -10.281 1.00 19.49 ? 320 ALA C C   1 
ATOM   7159 O  O   . ALA C 1 315 ? -19.611 8.154   -10.780 1.00 18.30 ? 320 ALA C O   1 
ATOM   7160 C  CB  . ALA C 1 315 ? -22.670 8.781   -9.802  1.00 19.52 ? 320 ALA C CB  1 
ATOM   7161 N  N   . SER C 1 316 ? -20.404 6.634   -9.304  1.00 18.85 ? 321 SER C N   1 
ATOM   7162 C  CA  . SER C 1 316 ? -19.085 6.282   -8.803  1.00 19.34 ? 321 SER C CA  1 
ATOM   7163 C  C   . SER C 1 316 ? -18.264 5.563   -9.845  1.00 19.28 ? 321 SER C C   1 
ATOM   7164 O  O   . SER C 1 316 ? -17.052 5.768   -9.909  1.00 19.41 ? 321 SER C O   1 
ATOM   7165 C  CB  . SER C 1 316 ? -19.162 5.452   -7.507  1.00 19.00 ? 321 SER C CB  1 
ATOM   7166 O  OG  . SER C 1 316 ? -19.822 6.218   -6.531  1.00 22.33 ? 321 SER C OG  1 
ATOM   7167 N  N   . SER C 1 317 ? -18.919 4.753   -10.677 1.00 19.08 ? 322 SER C N   1 
ATOM   7168 C  CA  . SER C 1 317 ? -18.224 4.139   -11.798 1.00 19.69 ? 322 SER C CA  1 
ATOM   7169 C  C   . SER C 1 317 ? -17.630 5.148   -12.811 1.00 19.93 ? 322 SER C C   1 
ATOM   7170 O  O   . SER C 1 317 ? -16.729 4.799   -13.571 1.00 18.98 ? 322 SER C O   1 
ATOM   7171 C  CB  . SER C 1 317 ? -19.144 3.136   -12.517 1.00 19.16 ? 322 SER C CB  1 
ATOM   7172 O  OG  . SER C 1 317 ? -19.546 2.082   -11.635 1.00 16.73 ? 322 SER C OG  1 
ATOM   7173 N  N   . PHE C 1 318 ? -18.158 6.374   -12.809 1.00 20.59 ? 323 PHE C N   1 
ATOM   7174 C  CA  . PHE C 1 318 ? -17.735 7.434   -13.725 1.00 20.90 ? 323 PHE C CA  1 
ATOM   7175 C  C   . PHE C 1 318 ? -17.116 8.667   -13.023 1.00 21.48 ? 323 PHE C C   1 
ATOM   7176 O  O   . PHE C 1 318 ? -16.932 9.726   -13.621 1.00 21.63 ? 323 PHE C O   1 
ATOM   7177 C  CB  . PHE C 1 318 ? -18.875 7.782   -14.705 1.00 20.68 ? 323 PHE C CB  1 
ATOM   7178 C  CG  . PHE C 1 318 ? -19.184 6.664   -15.699 1.00 21.78 ? 323 PHE C CG  1 
ATOM   7179 C  CD1 . PHE C 1 318 ? -18.302 6.383   -16.758 1.00 22.35 ? 323 PHE C CD1 1 
ATOM   7180 C  CD2 . PHE C 1 318 ? -20.351 5.890   -15.576 1.00 20.21 ? 323 PHE C CD2 1 
ATOM   7181 C  CE1 . PHE C 1 318 ? -18.567 5.344   -17.677 1.00 22.43 ? 323 PHE C CE1 1 
ATOM   7182 C  CE2 . PHE C 1 318 ? -20.630 4.847   -16.491 1.00 20.81 ? 323 PHE C CE2 1 
ATOM   7183 C  CZ  . PHE C 1 318 ? -19.765 4.582   -17.547 1.00 21.56 ? 323 PHE C CZ  1 
ATOM   7184 N  N   . GLY C 1 319 ? -16.778 8.516   -11.742 1.00 21.22 ? 324 GLY C N   1 
ATOM   7185 C  CA  . GLY C 1 319 ? -15.786 9.399   -11.115 1.00 20.87 ? 324 GLY C CA  1 
ATOM   7186 C  C   . GLY C 1 319 ? -16.232 10.068  -9.827  1.00 20.85 ? 324 GLY C C   1 
ATOM   7187 O  O   . GLY C 1 319 ? -15.470 10.830  -9.231  1.00 21.33 ? 324 GLY C O   1 
ATOM   7188 N  N   . GLN C 1 320 ? -17.469 9.817   -9.417  1.00 21.18 ? 325 GLN C N   1 
ATOM   7189 C  CA  . GLN C 1 320 ? -17.968 10.327  -8.125  1.00 23.19 ? 325 GLN C CA  1 
ATOM   7190 C  C   . GLN C 1 320 ? -17.181 9.635   -7.012  1.00 23.56 ? 325 GLN C C   1 
ATOM   7191 O  O   . GLN C 1 320 ? -17.009 8.424   -7.051  1.00 22.53 ? 325 GLN C O   1 
ATOM   7192 C  CB  . GLN C 1 320 ? -19.444 10.025  -7.955  1.00 22.36 ? 325 GLN C CB  1 
ATOM   7193 C  CG  . GLN C 1 320 ? -20.039 10.557  -6.634  1.00 27.07 ? 325 GLN C CG  1 
ATOM   7194 C  CD  . GLN C 1 320 ? -21.511 10.216  -6.501  1.00 31.75 ? 325 GLN C CD  1 
ATOM   7195 O  OE1 . GLN C 1 320 ? -21.906 9.260   -5.785  1.00 35.32 ? 325 GLN C OE1 1 
ATOM   7196 N  NE2 . GLN C 1 320 ? -22.331 10.947  -7.217  1.00 31.69 ? 325 GLN C NE2 1 
ATOM   7197 N  N   . THR C 1 321 ? -16.671 10.425  -6.069  1.00 26.01 ? 326 THR C N   1 
ATOM   7198 C  CA  . THR C 1 321 ? -15.830 9.915   -4.980  1.00 27.55 ? 326 THR C CA  1 
ATOM   7199 C  C   . THR C 1 321 ? -16.358 10.388  -3.624  1.00 28.01 ? 326 THR C C   1 
ATOM   7200 O  O   . THR C 1 321 ? -17.232 11.258  -3.542  1.00 27.04 ? 326 THR C O   1 
ATOM   7201 C  CB  . THR C 1 321 ? -14.363 10.391  -5.080  1.00 27.79 ? 326 THR C CB  1 
ATOM   7202 O  OG1 . THR C 1 321 ? -14.266 11.764  -4.678  1.00 31.33 ? 326 THR C OG1 1 
ATOM   7203 C  CG2 . THR C 1 321 ? -13.786 10.221  -6.501  1.00 29.31 ? 326 THR C CG2 1 
ATOM   7204 N  N   . ARG C 1 322 ? -15.787 9.787   -2.580  1.00 28.93 ? 327 ARG C N   1 
ATOM   7205 C  CA  . ARG C 1 322 ? -16.073 10.065  -1.184  1.00 29.82 ? 327 ARG C CA  1 
ATOM   7206 C  C   . ARG C 1 322 ? -15.120 11.136  -0.624  1.00 31.44 ? 327 ARG C C   1 
ATOM   7207 O  O   . ARG C 1 322 ? -14.978 11.245  0.587   1.00 31.80 ? 327 ARG C O   1 
ATOM   7208 C  CB  . ARG C 1 322 ? -15.859 8.767   -0.390  1.00 29.50 ? 327 ARG C CB  1 
ATOM   7209 C  CG  . ARG C 1 322 ? -17.083 8.034   0.131   1.00 29.23 ? 327 ARG C CG  1 
ATOM   7210 C  CD  . ARG C 1 322 ? -17.529 6.803   -0.642  1.00 25.04 ? 327 ARG C CD  1 
ATOM   7211 N  NE  . ARG C 1 322 ? -16.518 5.765   -0.896  1.00 23.24 ? 327 ARG C NE  1 
ATOM   7212 C  CZ  . ARG C 1 322 ? -16.220 4.727   -0.102  1.00 20.00 ? 327 ARG C CZ  1 
ATOM   7213 N  NH1 . ARG C 1 322 ? -16.800 4.553   1.099   1.00 14.07 ? 327 ARG C NH1 1 
ATOM   7214 N  NH2 . ARG C 1 322 ? -15.302 3.849   -0.524  1.00 15.81 ? 327 ARG C NH2 1 
ATOM   7215 N  N   . GLU C 1 323 ? -14.420 11.885  -1.476  1.00 33.50 ? 328 GLU C N   1 
ATOM   7216 C  CA  . GLU C 1 323 ? -13.410 12.834  -0.985  1.00 34.69 ? 328 GLU C CA  1 
ATOM   7217 C  C   . GLU C 1 323 ? -13.344 14.196  -1.714  1.00 35.66 ? 328 GLU C C   1 
ATOM   7218 O  O   . GLU C 1 323 ? -12.391 14.957  -1.520  1.00 35.33 ? 328 GLU C O   1 
ATOM   7219 C  CB  . GLU C 1 323 ? -12.019 12.173  -0.936  1.00 35.00 ? 328 GLU C CB  1 
ATOM   7220 C  CG  . GLU C 1 323 ? -11.409 11.926  -2.307  1.00 36.18 ? 328 GLU C CG  1 
ATOM   7221 C  CD  . GLU C 1 323 ? -9.945  11.523  -2.244  1.00 39.14 ? 328 GLU C CD  1 
ATOM   7222 O  OE1 . GLU C 1 323 ? -9.349  11.339  -3.335  1.00 40.78 ? 328 GLU C OE1 1 
ATOM   7223 O  OE2 . GLU C 1 323 ? -9.393  11.392  -1.122  1.00 37.90 ? 328 GLU C OE2 1 
ATOM   7224 N  N   . GLY C 1 324 ? -14.360 14.503  -2.517  1.00 36.98 ? 329 GLY C N   1 
ATOM   7225 C  CA  . GLY C 1 324 ? -14.442 15.783  -3.226  1.00 39.02 ? 329 GLY C CA  1 
ATOM   7226 C  C   . GLY C 1 324 ? -13.411 15.980  -4.332  1.00 40.64 ? 329 GLY C C   1 
ATOM   7227 O  O   . GLY C 1 324 ? -13.099 17.120  -4.700  1.00 40.79 ? 329 GLY C O   1 
ATOM   7228 N  N   . GLY C 1 325 ? -12.880 14.880  -4.867  1.00 41.25 ? 330 GLY C N   1 
ATOM   7229 C  CA  . GLY C 1 325 ? -11.805 14.953  -5.870  1.00 42.92 ? 330 GLY C CA  1 
ATOM   7230 C  C   . GLY C 1 325 ? -12.242 15.115  -7.326  1.00 43.93 ? 330 GLY C C   1 
ATOM   7231 O  O   . GLY C 1 325 ? -11.392 15.291  -8.195  1.00 43.97 ? 330 GLY C O   1 
ATOM   7232 N  N   . HIS C 1 326 ? -13.551 15.073  -7.594  1.00 44.84 ? 331 HIS C N   1 
ATOM   7233 C  CA  . HIS C 1 326 ? -14.082 15.156  -8.980  1.00 45.96 ? 331 HIS C CA  1 
ATOM   7234 C  C   . HIS C 1 326 ? -14.313 16.575  -9.524  1.00 46.22 ? 331 HIS C C   1 
ATOM   7235 O  O   . HIS C 1 326 ? -13.904 17.573  -8.918  1.00 46.80 ? 331 HIS C O   1 
ATOM   7236 C  CB  . HIS C 1 326 ? -15.359 14.305  -9.163  1.00 45.79 ? 331 HIS C CB  1 
ATOM   7237 C  CG  . HIS C 1 326 ? -16.252 14.262  -7.956  1.00 47.92 ? 331 HIS C CG  1 
ATOM   7238 N  ND1 . HIS C 1 326 ? -17.272 15.168  -7.746  1.00 48.06 ? 331 HIS C ND1 1 
ATOM   7239 C  CD2 . HIS C 1 326 ? -16.277 13.415  -6.895  1.00 49.05 ? 331 HIS C CD2 1 
ATOM   7240 C  CE1 . HIS C 1 326 ? -17.885 14.881  -6.608  1.00 50.12 ? 331 HIS C CE1 1 
ATOM   7241 N  NE2 . HIS C 1 326 ? -17.306 13.816  -6.076  1.00 49.63 ? 331 HIS C NE2 1 
HETATM 7242 MN MN  . MN  D 2 .   ? -18.845 19.163  11.544  1.00 39.53 ? 401 MN  A MN  1 
HETATM 7243 MN MN  . MN  E 2 .   ? -20.302 16.921  9.853   1.00 21.01 ? 402 MN  A MN  1 
HETATM 7244 S  S   . DMS F 3 .   ? -20.841 20.099  9.860   1.00 34.76 ? 403 DMS A S   1 
HETATM 7245 O  O   . DMS F 3 .   ? -19.671 18.787  9.540   1.00 34.25 ? 403 DMS A O   1 
HETATM 7246 C  C1  . DMS F 3 .   ? -22.482 19.352  10.034  1.00 34.46 ? 403 DMS A C1  1 
HETATM 7247 C  C2  . DMS F 3 .   ? -20.682 20.721  11.529  1.00 34.72 ? 403 DMS A C2  1 
HETATM 7248 S  S   . DMS G 3 .   ? -30.707 29.177  13.087  1.00 50.09 ? 404 DMS A S   1 
HETATM 7249 O  O   . DMS G 3 .   ? -31.688 30.072  14.305  1.00 49.87 ? 404 DMS A O   1 
HETATM 7250 C  C1  . DMS G 3 .   ? -31.955 28.664  11.888  1.00 48.78 ? 404 DMS A C1  1 
HETATM 7251 C  C2  . DMS G 3 .   ? -29.760 30.367  12.111  1.00 49.30 ? 404 DMS A C2  1 
HETATM 7252 N  N   . PRO H 4 .   ? -19.646 21.830  3.603   1.00 35.38 ? 405 PRO A N   1 
HETATM 7253 C  CA  . PRO H 4 .   ? -20.985 22.376  3.901   1.00 35.00 ? 405 PRO A CA  1 
HETATM 7254 C  C   . PRO H 4 .   ? -20.903 23.859  4.225   1.00 32.38 ? 405 PRO A C   1 
HETATM 7255 O  O   . PRO H 4 .   ? -19.873 24.488  4.088   1.00 31.38 ? 405 PRO A O   1 
HETATM 7256 C  CB  . PRO H 4 .   ? -21.486 21.566  5.133   1.00 35.73 ? 405 PRO A CB  1 
HETATM 7257 C  CG  . PRO H 4 .   ? -20.817 20.178  4.928   1.00 37.44 ? 405 PRO A CG  1 
HETATM 7258 C  CD  . PRO H 4 .   ? -19.759 20.376  3.814   1.00 36.07 ? 405 PRO A CD  1 
HETATM 7259 O  OXT . PRO H 4 .   ? -21.992 24.476  4.674   1.00 33.08 ? 405 PRO A OXT 1 
HETATM 7260 MN MN  . MN  I 2 .   ? -26.296 -16.040 26.789  1.00 36.77 ? 401 MN  B MN  1 
HETATM 7261 MN MN  . MN  J 2 .   ? -26.447 -13.159 25.663  1.00 24.47 ? 402 MN  B MN  1 
HETATM 7262 S  S   . DMS K 3 .   ? -27.928 -14.227 28.444  1.00 42.68 ? 403 DMS B S   1 
HETATM 7263 O  O   . DMS K 3 .   ? -26.228 -14.063 27.889  1.00 41.53 ? 403 DMS B O   1 
HETATM 7264 C  C1  . DMS K 3 .   ? -28.995 -13.291 27.335  1.00 41.18 ? 403 DMS B C1  1 
HETATM 7265 C  C2  . DMS K 3 .   ? -28.555 -15.881 28.096  1.00 41.42 ? 403 DMS B C2  1 
HETATM 7266 S  S   . DMS L 3 .   ? -10.741 -8.335  6.739   1.00 45.46 ? 404 DMS B S   1 
HETATM 7267 O  O   . DMS L 3 .   ? -11.873 -7.041  6.229   1.00 42.54 ? 404 DMS B O   1 
HETATM 7268 C  C1  . DMS L 3 .   ? -9.068  -7.649  6.886   1.00 43.12 ? 404 DMS B C1  1 
HETATM 7269 C  C2  . DMS L 3 .   ? -10.986 -8.640  8.501   1.00 41.38 ? 404 DMS B C2  1 
HETATM 7270 N  N   . PRO M 4 .   ? -25.206 -10.133 33.076  1.00 41.31 ? 405 PRO B N   1 
HETATM 7271 C  CA  . PRO M 4 .   ? -26.651 -10.426 33.193  1.00 39.86 ? 405 PRO B CA  1 
HETATM 7272 C  C   . PRO M 4 .   ? -26.930 -11.324 34.379  1.00 37.65 ? 405 PRO B C   1 
HETATM 7273 O  O   . PRO M 4 .   ? -28.194 -11.664 34.636  1.00 36.45 ? 405 PRO B O   1 
HETATM 7274 C  CB  . PRO M 4 .   ? -27.005 -11.205 31.903  1.00 40.58 ? 405 PRO B CB  1 
HETATM 7275 C  CG  . PRO M 4 .   ? -26.073 -10.547 30.852  1.00 42.95 ? 405 PRO B CG  1 
HETATM 7276 C  CD  . PRO M 4 .   ? -24.912 -9.907  31.654  1.00 42.38 ? 405 PRO B CD  1 
HETATM 7277 O  OXT . PRO M 4 .   ? -26.026 -11.746 35.079  1.00 35.42 ? 405 PRO B OXT 1 
HETATM 7278 MN MN  . MN  N 2 .   ? -27.943 -11.488 -11.721 1.00 42.51 ? 401 MN  C MN  1 
HETATM 7279 MN MN  . MN  O 2 .   ? -28.532 -11.393 -8.698  1.00 23.29 ? 402 MN  C MN  1 
HETATM 7280 S  S   . DMS P 3 .   ? -30.333 -12.727 -11.019 1.00 39.17 ? 403 DMS C S   1 
HETATM 7281 O  O   . DMS P 3 .   ? -28.712 -12.751 -10.275 1.00 39.19 ? 403 DMS C O   1 
HETATM 7282 C  C1  . DMS P 3 .   ? -31.497 -12.206 -9.740  1.00 38.93 ? 403 DMS C C1  1 
HETATM 7283 C  C2  . DMS P 3 .   ? -30.440 -11.274 -12.066 1.00 40.18 ? 403 DMS C C2  1 
HETATM 7284 S  S   . DMS Q 3 .   ? -9.941  -16.809 -4.722  1.00 49.00 ? 404 DMS C S   1 
HETATM 7285 O  O   . DMS Q 3 .   ? -10.457 -16.388 -6.397  1.00 48.15 ? 404 DMS C O   1 
HETATM 7286 C  C1  . DMS Q 3 .   ? -8.479  -15.849 -4.210  1.00 48.54 ? 404 DMS C C1  1 
HETATM 7287 C  C2  . DMS Q 3 .   ? -11.115 -16.051 -3.577  1.00 47.78 ? 404 DMS C C2  1 
HETATM 7288 N  N   . PRO R 4 .   ? -30.035 -19.381 -9.420  1.00 44.73 ? 405 PRO C N   1 
HETATM 7289 C  CA  . PRO R 4 .   ? -31.409 -18.907 -9.669  1.00 43.03 ? 405 PRO C CA  1 
HETATM 7290 C  C   . PRO R 4 .   ? -31.897 -19.307 -11.042 1.00 42.65 ? 405 PRO C C   1 
HETATM 7291 O  O   . PRO R 4 .   ? -31.194 -19.931 -11.805 1.00 41.03 ? 405 PRO C O   1 
HETATM 7292 C  CB  . PRO R 4 .   ? -31.319 -17.363 -9.629  1.00 43.90 ? 405 PRO C CB  1 
HETATM 7293 C  CG  . PRO R 4 .   ? -30.254 -17.147 -8.534  1.00 45.36 ? 405 PRO C CG  1 
HETATM 7294 C  CD  . PRO R 4 .   ? -29.405 -18.445 -8.479  1.00 44.27 ? 405 PRO C CD  1 
HETATM 7295 O  OXT . PRO R 4 .   ? -33.123 -18.938 -11.425 1.00 40.97 ? 405 PRO C OXT 1 
HETATM 7296 O  O   . HOH S 5 .   ? 10.569  13.021  20.506  1.00 31.40 ? 501 HOH A O   1 
HETATM 7297 O  O   . HOH S 5 .   ? -29.738 21.261  29.552  1.00 34.32 ? 502 HOH A O   1 
HETATM 7298 O  O   . HOH S 5 .   ? 2.830   21.121  14.420  1.00 45.42 ? 503 HOH A O   1 
HETATM 7299 O  O   . HOH S 5 .   ? -17.492 22.293  5.011   1.00 20.86 ? 504 HOH A O   1 
HETATM 7300 O  O   . HOH S 5 .   ? -5.837  20.233  32.308  1.00 26.03 ? 505 HOH A O   1 
HETATM 7301 O  O   . HOH S 5 .   ? -7.048  35.687  8.733   1.00 37.25 ? 506 HOH A O   1 
HETATM 7302 O  O   . HOH S 5 .   ? -20.292 10.650  -0.027  1.00 33.64 ? 507 HOH A O   1 
HETATM 7303 O  O   . HOH S 5 .   ? -3.904  15.205  2.339   1.00 34.74 ? 508 HOH A O   1 
HETATM 7304 O  O   . HOH S 5 .   ? 5.352   9.005   14.412  1.00 32.99 ? 509 HOH A O   1 
HETATM 7305 O  O   . HOH S 5 .   ? -26.606 0.630   10.377  1.00 36.09 ? 510 HOH A O   1 
HETATM 7306 O  O   . HOH S 5 .   ? -16.714 -1.363  9.058   1.00 15.33 ? 511 HOH A O   1 
HETATM 7307 O  O   . HOH S 5 .   ? -16.884 1.411   24.057  1.00 30.52 ? 512 HOH A O   1 
HETATM 7308 O  O   . HOH S 5 .   ? -8.751  -8.210  49.897  1.00 48.44 ? 513 HOH A O   1 
HETATM 7309 O  O   . HOH S 5 .   ? -10.205 9.153   0.044   1.00 23.12 ? 514 HOH A O   1 
HETATM 7310 O  O   . HOH S 5 .   ? -27.090 19.199  13.368  1.00 20.76 ? 515 HOH A O   1 
HETATM 7311 O  O   . HOH S 5 .   ? -19.594 -1.072  27.087  1.00 27.91 ? 516 HOH A O   1 
HETATM 7312 O  O   . HOH S 5 .   ? -24.928 17.207  10.818  1.00 19.57 ? 517 HOH A O   1 
HETATM 7313 O  O   . HOH S 5 .   ? -7.052  16.554  30.864  1.00 33.89 ? 518 HOH A O   1 
HETATM 7314 O  O   . HOH S 5 .   ? -35.463 17.506  25.675  1.00 41.36 ? 519 HOH A O   1 
HETATM 7315 O  O   . HOH S 5 .   ? -31.808 12.095  9.258   1.00 32.34 ? 520 HOH A O   1 
HETATM 7316 O  O   . HOH S 5 .   ? -19.274 26.889  4.984   1.00 27.92 ? 521 HOH A O   1 
HETATM 7317 O  O   . HOH S 5 .   ? -16.546 18.926  4.092   1.00 21.88 ? 522 HOH A O   1 
HETATM 7318 O  O   . HOH S 5 .   ? -1.980  5.998   5.863   1.00 36.52 ? 523 HOH A O   1 
HETATM 7319 O  O   . HOH S 5 .   ? -19.842 2.155   38.689  1.00 30.80 ? 524 HOH A O   1 
HETATM 7320 O  O   . HOH S 5 .   ? -0.144  0.961   11.676  1.00 38.38 ? 525 HOH A O   1 
HETATM 7321 O  O   . HOH S 5 .   ? 3.523   18.416  24.258  1.00 32.31 ? 526 HOH A O   1 
HETATM 7322 O  O   . HOH S 5 .   ? -9.976  31.785  0.961   1.00 30.67 ? 527 HOH A O   1 
HETATM 7323 O  O   . HOH S 5 .   ? -12.444 3.359   26.608  1.00 16.68 ? 528 HOH A O   1 
HETATM 7324 O  O   . HOH S 5 .   ? -10.216 2.000   26.417  1.00 28.52 ? 529 HOH A O   1 
HETATM 7325 O  O   . HOH S 5 .   ? -7.287  19.045  30.000  1.00 21.97 ? 530 HOH A O   1 
HETATM 7326 O  O   . HOH S 5 .   ? -24.270 17.542  19.914  1.00 16.23 ? 531 HOH A O   1 
HETATM 7327 O  O   . HOH S 5 .   ? -17.512 -2.081  11.677  1.00 12.44 ? 532 HOH A O   1 
HETATM 7328 O  O   . HOH S 5 .   ? -34.223 20.046  28.898  1.00 41.89 ? 533 HOH A O   1 
HETATM 7329 O  O   . HOH S 5 .   ? -2.313  16.657  9.135   1.00 25.88 ? 534 HOH A O   1 
HETATM 7330 O  O   . HOH S 5 .   ? -25.815 5.325   25.780  1.00 24.55 ? 535 HOH A O   1 
HETATM 7331 O  O   . HOH S 5 .   ? -5.901  -4.369  11.875  1.00 27.19 ? 536 HOH A O   1 
HETATM 7332 O  O   . HOH S 5 .   ? -32.207 12.293  24.978  1.00 24.70 ? 537 HOH A O   1 
HETATM 7333 O  O   . HOH S 5 .   ? -4.483  3.017   18.254  1.00 23.98 ? 538 HOH A O   1 
HETATM 7334 O  O   . HOH S 5 .   ? -0.129  22.544  18.590  1.00 25.07 ? 539 HOH A O   1 
HETATM 7335 O  O   . HOH S 5 .   ? -24.278 23.790  5.972   1.00 25.88 ? 540 HOH A O   1 
HETATM 7336 O  O   . HOH S 5 .   ? -18.955 5.994   2.410   1.00 17.50 ? 541 HOH A O   1 
HETATM 7337 O  O   . HOH S 5 .   ? -16.003 -1.255  3.906   1.00 17.81 ? 542 HOH A O   1 
HETATM 7338 O  O   . HOH S 5 .   ? -16.951 14.203  -0.903  1.00 32.12 ? 543 HOH A O   1 
HETATM 7339 O  O   . HOH S 5 .   ? -23.330 30.744  10.321  1.00 25.53 ? 544 HOH A O   1 
HETATM 7340 O  O   . HOH S 5 .   ? -21.766 20.852  0.575   1.00 49.22 ? 545 HOH A O   1 
HETATM 7341 O  O   . HOH S 5 .   ? -18.736 -4.932  28.844  1.00 25.06 ? 546 HOH A O   1 
HETATM 7342 O  O   . HOH S 5 .   ? -10.704 -3.778  2.479   1.00 13.60 ? 547 HOH A O   1 
HETATM 7343 O  O   . HOH S 5 .   ? -25.508 10.562  10.704  1.00 15.29 ? 548 HOH A O   1 
HETATM 7344 O  O   . HOH S 5 .   ? -20.213 25.574  1.368   1.00 35.75 ? 549 HOH A O   1 
HETATM 7345 O  O   . HOH S 5 .   ? -27.087 5.201   5.299   1.00 34.25 ? 550 HOH A O   1 
HETATM 7346 O  O   . HOH S 5 .   ? -14.026 40.600  18.146  1.00 42.61 ? 551 HOH A O   1 
HETATM 7347 O  O   . HOH S 5 .   ? -5.858  4.292   2.054   1.00 24.24 ? 552 HOH A O   1 
HETATM 7348 O  O   . HOH S 5 .   ? -24.173 11.405  8.520   1.00 17.04 ? 553 HOH A O   1 
HETATM 7349 O  O   . HOH S 5 .   ? -26.716 13.864  32.361  1.00 25.53 ? 554 HOH A O   1 
HETATM 7350 O  O   . HOH S 5 .   ? -13.889 -5.942  36.612  1.00 38.13 ? 555 HOH A O   1 
HETATM 7351 O  O   . HOH S 5 .   ? -6.195  10.160  2.518   1.00 30.15 ? 556 HOH A O   1 
HETATM 7352 O  O   . HOH S 5 .   ? -5.590  1.137   16.761  1.00 21.36 ? 557 HOH A O   1 
HETATM 7353 O  O   . HOH S 5 .   ? -12.977 -0.630  10.117  1.00 13.87 ? 558 HOH A O   1 
HETATM 7354 O  O   . HOH S 5 .   ? -22.065 2.259   7.643   1.00 33.25 ? 559 HOH A O   1 
HETATM 7355 O  O   . HOH S 5 .   ? -4.502  4.035   21.987  1.00 30.07 ? 560 HOH A O   1 
HETATM 7356 O  O   . HOH S 5 .   ? 2.392   5.500   10.542  1.00 29.92 ? 561 HOH A O   1 
HETATM 7357 O  O   . HOH S 5 .   ? -39.948 6.029   18.783  1.00 35.11 ? 562 HOH A O   1 
HETATM 7358 O  O   . HOH S 5 .   ? -43.436 10.134  22.531  1.00 47.74 ? 563 HOH A O   1 
HETATM 7359 O  O   . HOH S 5 .   ? -20.534 8.083   1.287   1.00 14.85 ? 564 HOH A O   1 
HETATM 7360 O  O   . HOH S 5 .   ? -12.081 36.064  10.528  1.00 31.87 ? 565 HOH A O   1 
HETATM 7361 O  O   . HOH S 5 .   ? -12.601 7.821   35.386  1.00 25.57 ? 566 HOH A O   1 
HETATM 7362 O  O   . HOH S 5 .   ? -7.010  -2.132  10.766  1.00 23.26 ? 567 HOH A O   1 
HETATM 7363 O  O   . HOH S 5 .   ? -31.577 15.094  8.826   1.00 24.99 ? 568 HOH A O   1 
HETATM 7364 O  O   . HOH S 5 .   ? -14.270 20.992  24.312  1.00 18.29 ? 569 HOH A O   1 
HETATM 7365 O  O   . HOH S 5 .   ? -8.391  12.143  29.781  1.00 28.07 ? 570 HOH A O   1 
HETATM 7366 O  O   . HOH S 5 .   ? -13.873 5.328   45.274  1.00 20.76 ? 571 HOH A O   1 
HETATM 7367 O  O   . HOH S 5 .   ? -10.214 19.814  -5.364  1.00 47.05 ? 572 HOH A O   1 
HETATM 7368 O  O   . HOH S 5 .   ? 0.082   4.431   16.998  1.00 25.71 ? 573 HOH A O   1 
HETATM 7369 O  O   . HOH S 5 .   ? -27.060 12.001  34.334  1.00 34.54 ? 574 HOH A O   1 
HETATM 7370 O  O   . HOH S 5 .   ? -5.178  -0.513  -3.878  1.00 33.29 ? 575 HOH A O   1 
HETATM 7371 O  O   . HOH S 5 .   ? 6.739   13.260  25.100  1.00 41.84 ? 576 HOH A O   1 
HETATM 7372 O  O   . HOH S 5 .   ? -3.318  15.354  28.110  1.00 32.82 ? 577 HOH A O   1 
HETATM 7373 O  O   . HOH S 5 .   ? -20.422 -9.516  43.210  1.00 45.25 ? 578 HOH A O   1 
HETATM 7374 O  O   . HOH S 5 .   ? -37.363 5.476   11.269  1.00 45.09 ? 579 HOH A O   1 
HETATM 7375 O  O   . HOH S 5 .   ? -16.650 28.258  -3.891  1.00 39.51 ? 580 HOH A O   1 
HETATM 7376 O  O   . HOH S 5 .   ? -17.424 14.315  41.055  1.00 32.43 ? 581 HOH A O   1 
HETATM 7377 O  O   . HOH S 5 .   ? -29.945 22.102  25.073  1.00 22.92 ? 582 HOH A O   1 
HETATM 7378 O  O   . HOH S 5 .   ? -25.435 19.952  10.343  1.00 24.26 ? 583 HOH A O   1 
HETATM 7379 O  O   . HOH S 5 .   ? 3.560   22.975  18.499  1.00 36.24 ? 584 HOH A O   1 
HETATM 7380 O  O   . HOH S 5 .   ? -28.255 11.747  3.301   1.00 35.15 ? 585 HOH A O   1 
HETATM 7381 O  O   . HOH S 5 .   ? -29.013 20.885  12.531  1.00 21.44 ? 586 HOH A O   1 
HETATM 7382 O  O   . HOH S 5 .   ? 1.008   18.167  7.435   1.00 47.50 ? 587 HOH A O   1 
HETATM 7383 O  O   . HOH S 5 .   ? -25.241 2.615   5.028   1.00 32.65 ? 588 HOH A O   1 
HETATM 7384 O  O   . HOH S 5 .   ? 0.007   23.184  16.131  1.00 32.00 ? 589 HOH A O   1 
HETATM 7385 O  O   . HOH S 5 .   ? -7.151  9.819   27.152  1.00 19.81 ? 590 HOH A O   1 
HETATM 7386 O  O   . HOH S 5 .   ? -0.350  15.200  10.398  1.00 29.54 ? 591 HOH A O   1 
HETATM 7387 O  O   . HOH S 5 .   ? -23.321 -0.175  13.424  1.00 19.97 ? 592 HOH A O   1 
HETATM 7388 O  O   . HOH S 5 .   ? -19.297 1.016   24.674  1.00 34.07 ? 593 HOH A O   1 
HETATM 7389 O  O   . HOH S 5 .   ? -23.850 1.506   26.380  1.00 31.38 ? 594 HOH A O   1 
HETATM 7390 O  O   . HOH S 5 .   ? -32.712 22.473  25.379  1.00 33.67 ? 595 HOH A O   1 
HETATM 7391 O  O   . HOH S 5 .   ? -13.855 -2.912  4.003   1.00 21.11 ? 596 HOH A O   1 
HETATM 7392 O  O   . HOH S 5 .   ? -9.232  9.793   28.572  1.00 20.94 ? 597 HOH A O   1 
HETATM 7393 O  O   . HOH S 5 .   ? -26.401 10.877  1.677   1.00 25.87 ? 598 HOH A O   1 
HETATM 7394 O  O   . HOH S 5 .   ? -4.369  12.542  3.532   1.00 28.61 ? 599 HOH A O   1 
HETATM 7395 O  O   . HOH S 5 .   ? 0.735   22.181  25.412  1.00 35.21 ? 600 HOH A O   1 
HETATM 7396 O  O   . HOH S 5 .   ? -16.356 5.371   44.688  1.00 27.89 ? 601 HOH A O   1 
HETATM 7397 O  O   . HOH S 5 .   ? -28.196 24.258  7.736   1.00 26.29 ? 602 HOH A O   1 
HETATM 7398 O  O   . HOH S 5 .   ? -9.221  18.984  38.251  1.00 35.69 ? 603 HOH A O   1 
HETATM 7399 O  O   . HOH S 5 .   ? -9.872  -4.424  35.651  1.00 32.94 ? 604 HOH A O   1 
HETATM 7400 O  O   . HOH S 5 .   ? -4.078  2.507   2.045   1.00 40.05 ? 605 HOH A O   1 
HETATM 7401 O  O   . HOH S 5 .   ? -21.477 -1.662  14.486  1.00 13.17 ? 606 HOH A O   1 
HETATM 7402 O  O   . HOH S 5 .   ? -26.740 6.571   32.328  1.00 40.53 ? 607 HOH A O   1 
HETATM 7403 O  O   . HOH S 5 .   ? -29.955 3.477   21.512  1.00 35.63 ? 608 HOH A O   1 
HETATM 7404 O  O   . HOH S 5 .   ? -42.637 12.489  12.213  1.00 41.13 ? 609 HOH A O   1 
HETATM 7405 O  O   . HOH S 5 .   ? -16.536 -2.097  44.765  1.00 34.50 ? 610 HOH A O   1 
HETATM 7406 O  O   . HOH S 5 .   ? -27.195 16.431  33.255  1.00 29.03 ? 611 HOH A O   1 
HETATM 7407 O  O   . HOH S 5 .   ? -0.262  32.493  5.966   1.00 50.71 ? 612 HOH A O   1 
HETATM 7408 O  O   . HOH S 5 .   ? -18.403 15.246  -2.836  1.00 55.12 ? 613 HOH A O   1 
HETATM 7409 O  O   . HOH S 5 .   ? -29.487 1.168   13.853  1.00 44.39 ? 614 HOH A O   1 
HETATM 7410 O  O   . HOH S 5 .   ? -27.262 3.840   20.425  1.00 40.14 ? 615 HOH A O   1 
HETATM 7411 O  O   . HOH S 5 .   ? 8.453   20.428  20.690  1.00 48.95 ? 616 HOH A O   1 
HETATM 7412 O  O   . HOH S 5 .   ? -34.042 17.564  23.638  1.00 41.19 ? 617 HOH A O   1 
HETATM 7413 O  O   . HOH S 5 .   ? -11.701 7.056   -5.445  1.00 30.08 ? 618 HOH A O   1 
HETATM 7414 O  O   . HOH S 5 .   ? -22.062 24.014  0.534   1.00 48.63 ? 619 HOH A O   1 
HETATM 7415 O  O   . HOH S 5 .   ? -19.326 -4.165  11.158  1.00 17.06 ? 620 HOH A O   1 
HETATM 7416 O  O   . HOH S 5 .   ? 1.616   6.660   18.807  1.00 52.63 ? 621 HOH A O   1 
HETATM 7417 O  O   . HOH S 5 .   ? -27.128 12.764  37.130  1.00 46.80 ? 622 HOH A O   1 
HETATM 7418 O  O   . HOH S 5 .   ? -21.576 -3.592  12.439  1.00 23.00 ? 623 HOH A O   1 
HETATM 7419 O  O   . HOH S 5 .   ? -29.206 10.263  5.093   1.00 35.38 ? 624 HOH A O   1 
HETATM 7420 O  O   . HOH S 5 .   ? 1.820   15.284  8.442   1.00 36.17 ? 625 HOH A O   1 
HETATM 7421 O  O   . HOH S 5 .   ? -32.143 22.027  29.338  1.00 38.66 ? 626 HOH A O   1 
HETATM 7422 O  O   . HOH S 5 .   ? -1.684  3.302   18.404  1.00 34.06 ? 627 HOH A O   1 
HETATM 7423 O  O   . HOH S 5 .   ? -23.660 0.014   10.871  1.00 38.13 ? 628 HOH A O   1 
HETATM 7424 O  O   . HOH S 5 .   ? 3.246   23.911  26.671  1.00 48.80 ? 629 HOH A O   1 
HETATM 7425 O  O   . HOH S 5 .   ? -20.474 -3.547  8.549   1.00 20.67 ? 630 HOH A O   1 
HETATM 7426 O  O   . HOH T 5 .   ? -27.532 -30.454 -13.393 1.00 26.08 ? 501 HOH B O   1 
HETATM 7427 O  O   . HOH T 5 .   ? -23.711 -12.761 32.867  1.00 29.14 ? 502 HOH B O   1 
HETATM 7428 O  O   . HOH T 5 .   ? -10.146 -20.400 27.325  1.00 21.40 ? 503 HOH B O   1 
HETATM 7429 O  O   . HOH T 5 .   ? -28.210 -33.890 -29.035 1.00 49.64 ? 504 HOH B O   1 
HETATM 7430 O  O   . HOH T 5 .   ? -40.841 -18.265 12.736  1.00 35.50 ? 505 HOH B O   1 
HETATM 7431 O  O   . HOH T 5 .   ? -21.433 -27.144 39.386  1.00 29.37 ? 506 HOH B O   1 
HETATM 7432 O  O   . HOH T 5 .   ? -15.968 -34.819 -12.593 1.00 37.68 ? 507 HOH B O   1 
HETATM 7433 O  O   . HOH T 5 .   ? -32.458 -16.055 6.387   1.00 40.00 ? 508 HOH B O   1 
HETATM 7434 O  O   . HOH T 5 .   ? -8.589  -13.685 29.571  1.00 40.37 ? 509 HOH B O   1 
HETATM 7435 O  O   . HOH T 5 .   ? -7.834  -25.897 24.890  1.00 31.48 ? 510 HOH B O   1 
HETATM 7436 O  O   . HOH T 5 .   ? -33.616 -18.522 7.228   1.00 23.91 ? 511 HOH B O   1 
HETATM 7437 O  O   . HOH T 5 .   ? -23.024 -36.074 18.646  1.00 27.03 ? 512 HOH B O   1 
HETATM 7438 O  O   . HOH T 5 .   ? -32.282 -10.236 10.609  1.00 37.38 ? 513 HOH B O   1 
HETATM 7439 O  O   . HOH T 5 .   ? -10.918 -20.901 10.985  1.00 28.24 ? 514 HOH B O   1 
HETATM 7440 O  O   . HOH T 5 .   ? -30.791 -11.965 24.956  1.00 22.23 ? 515 HOH B O   1 
HETATM 7441 O  O   . HOH T 5 .   ? -6.392  -8.855  10.829  1.00 36.46 ? 516 HOH B O   1 
HETATM 7442 O  O   . HOH T 5 .   ? -29.618 -9.129  19.243  1.00 16.98 ? 517 HOH B O   1 
HETATM 7443 O  O   . HOH T 5 .   ? -27.268 -28.977 22.461  1.00 22.48 ? 518 HOH B O   1 
HETATM 7444 O  O   . HOH T 5 .   ? -21.700 -10.870 30.457  1.00 21.32 ? 519 HOH B O   1 
HETATM 7445 O  O   . HOH T 5 .   ? -34.408 -40.310 12.058  1.00 26.58 ? 520 HOH B O   1 
HETATM 7446 O  O   . HOH T 5 .   ? -21.078 -24.341 6.373   1.00 17.29 ? 521 HOH B O   1 
HETATM 7447 O  O   . HOH T 5 .   ? -33.484 -17.762 36.920  1.00 21.75 ? 522 HOH B O   1 
HETATM 7448 O  O   . HOH T 5 .   ? -10.686 -30.233 11.571  1.00 37.91 ? 523 HOH B O   1 
HETATM 7449 O  O   . HOH T 5 .   ? -34.366 -13.909 25.066  1.00 18.40 ? 524 HOH B O   1 
HETATM 7450 O  O   . HOH T 5 .   ? -17.833 -6.447  10.516  1.00 16.63 ? 525 HOH B O   1 
HETATM 7451 O  O   . HOH T 5 .   ? -33.710 -19.710 20.751  1.00 17.59 ? 526 HOH B O   1 
HETATM 7452 O  O   . HOH T 5 .   ? -25.047 -1.363  15.758  1.00 39.62 ? 527 HOH B O   1 
HETATM 7453 O  O   . HOH T 5 .   ? -26.940 -13.812 36.538  1.00 29.55 ? 528 HOH B O   1 
HETATM 7454 O  O   . HOH T 5 .   ? -30.515 -11.207 32.901  1.00 32.22 ? 529 HOH B O   1 
HETATM 7455 O  O   . HOH T 5 .   ? -27.518 -1.955  17.223  1.00 30.69 ? 530 HOH B O   1 
HETATM 7456 O  O   . HOH T 5 .   ? -8.565  -19.516 7.661   1.00 32.02 ? 531 HOH B O   1 
HETATM 7457 O  O   . HOH T 5 .   ? -7.384  -4.388  22.646  1.00 33.80 ? 532 HOH B O   1 
HETATM 7458 O  O   . HOH T 5 .   ? -26.110 -16.894 4.291   1.00 30.98 ? 533 HOH B O   1 
HETATM 7459 O  O   . HOH T 5 .   ? -10.737 -18.379 9.819   1.00 22.52 ? 534 HOH B O   1 
HETATM 7460 O  O   . HOH T 5 .   ? -20.492 -33.397 -18.973 1.00 36.30 ? 535 HOH B O   1 
HETATM 7461 O  O   . HOH T 5 .   ? -38.156 -16.133 36.724  1.00 41.79 ? 536 HOH B O   1 
HETATM 7462 O  O   . HOH T 5 .   ? -18.632 -16.460 43.886  1.00 27.89 ? 537 HOH B O   1 
HETATM 7463 O  O   . HOH T 5 .   ? -22.427 -5.362  32.400  1.00 35.77 ? 538 HOH B O   1 
HETATM 7464 O  O   . HOH T 5 .   ? -10.562 -35.599 21.797  1.00 37.29 ? 539 HOH B O   1 
HETATM 7465 O  O   . HOH T 5 .   ? -36.478 -13.263 26.771  1.00 28.92 ? 540 HOH B O   1 
HETATM 7466 O  O   . HOH T 5 .   ? -12.714 -31.101 27.934  1.00 26.29 ? 541 HOH B O   1 
HETATM 7467 O  O   . HOH T 5 .   ? -8.308  -11.973 7.456   1.00 30.24 ? 542 HOH B O   1 
HETATM 7468 O  O   . HOH T 5 .   ? -23.238 -19.957 5.335   1.00 30.77 ? 543 HOH B O   1 
HETATM 7469 O  O   . HOH T 5 .   ? -13.609 -6.757  11.804  1.00 28.81 ? 544 HOH B O   1 
HETATM 7470 O  O   . HOH T 5 .   ? -19.512 -3.257  20.015  1.00 16.57 ? 545 HOH B O   1 
HETATM 7471 O  O   . HOH T 5 .   ? -27.763 -8.122  21.166  1.00 19.85 ? 546 HOH B O   1 
HETATM 7472 O  O   . HOH T 5 .   ? -19.099 -7.908  8.589   1.00 13.72 ? 547 HOH B O   1 
HETATM 7473 O  O   . HOH T 5 .   ? -12.659 -24.888 43.099  1.00 45.53 ? 548 HOH B O   1 
HETATM 7474 O  O   . HOH T 5 .   ? -9.260  -11.700 9.980   1.00 23.24 ? 549 HOH B O   1 
HETATM 7475 O  O   . HOH T 5 .   ? -15.468 -2.810  13.033  1.00 16.38 ? 550 HOH B O   1 
HETATM 7476 O  O   . HOH T 5 .   ? -9.614  -2.521  12.182  1.00 17.57 ? 551 HOH B O   1 
HETATM 7477 O  O   . HOH T 5 .   ? -18.747 -24.425 5.253   1.00 28.62 ? 552 HOH B O   1 
HETATM 7478 O  O   . HOH T 5 .   ? -33.811 -37.522 7.814   1.00 30.24 ? 553 HOH B O   1 
HETATM 7479 O  O   . HOH T 5 .   ? -20.401 -32.515 0.434   1.00 46.97 ? 554 HOH B O   1 
HETATM 7480 O  O   . HOH T 5 .   ? -7.308  -14.049 4.012   1.00 40.37 ? 555 HOH B O   1 
HETATM 7481 O  O   . HOH T 5 .   ? -19.075 -30.155 3.881   1.00 37.32 ? 556 HOH B O   1 
HETATM 7482 O  O   . HOH T 5 .   ? -26.296 -19.793 2.076   1.00 29.73 ? 557 HOH B O   1 
HETATM 7483 O  O   . HOH T 5 .   ? -18.358 -29.760 12.209  1.00 27.36 ? 558 HOH B O   1 
HETATM 7484 O  O   . HOH T 5 .   ? -24.575 -24.089 0.179   1.00 33.71 ? 559 HOH B O   1 
HETATM 7485 O  O   . HOH T 5 .   ? -19.488 -20.193 2.483   1.00 27.77 ? 560 HOH B O   1 
HETATM 7486 O  O   . HOH T 5 .   ? -6.081  -35.153 16.945  1.00 26.00 ? 561 HOH B O   1 
HETATM 7487 O  O   . HOH T 5 .   ? -7.598  -25.054 32.251  1.00 39.39 ? 562 HOH B O   1 
HETATM 7488 O  O   . HOH T 5 .   ? -12.413 -24.439 10.307  1.00 28.97 ? 563 HOH B O   1 
HETATM 7489 O  O   . HOH T 5 .   ? -39.027 -27.036 10.861  1.00 29.78 ? 564 HOH B O   1 
HETATM 7490 O  O   . HOH T 5 .   ? -21.482 -32.129 12.637  1.00 37.78 ? 565 HOH B O   1 
HETATM 7491 O  O   . HOH T 5 .   ? -21.817 -28.440 -5.559  1.00 36.62 ? 566 HOH B O   1 
HETATM 7492 O  O   . HOH T 5 .   ? -5.704  -28.576 21.831  1.00 26.19 ? 567 HOH B O   1 
HETATM 7493 O  O   . HOH T 5 .   ? -14.827 -9.277  10.901  1.00 14.08 ? 568 HOH B O   1 
HETATM 7494 O  O   . HOH T 5 .   ? -20.854 -29.735 11.154  1.00 25.78 ? 569 HOH B O   1 
HETATM 7495 O  O   . HOH T 5 .   ? -6.667  -22.286 13.099  1.00 31.04 ? 570 HOH B O   1 
HETATM 7496 O  O   . HOH T 5 .   ? -8.148  -21.622 25.660  1.00 28.17 ? 571 HOH B O   1 
HETATM 7497 O  O   . HOH T 5 .   ? -21.116 -2.617  22.121  1.00 16.69 ? 572 HOH B O   1 
HETATM 7498 O  O   . HOH T 5 .   ? -4.660  -14.873 8.905   1.00 34.05 ? 573 HOH B O   1 
HETATM 7499 O  O   . HOH T 5 .   ? -25.381 -7.710  8.864   1.00 21.33 ? 574 HOH B O   1 
HETATM 7500 O  O   . HOH T 5 .   ? -23.159 -8.791  38.472  1.00 36.81 ? 575 HOH B O   1 
HETATM 7501 O  O   . HOH T 5 .   ? -35.015 -11.161 32.320  1.00 32.85 ? 576 HOH B O   1 
HETATM 7502 O  O   . HOH T 5 .   ? -8.855  -37.943 15.411  1.00 35.56 ? 577 HOH B O   1 
HETATM 7503 O  O   . HOH T 5 .   ? -24.721 -20.645 -2.027  1.00 20.53 ? 578 HOH B O   1 
HETATM 7504 O  O   . HOH T 5 .   ? -41.947 -23.510 21.628  1.00 35.39 ? 579 HOH B O   1 
HETATM 7505 O  O   . HOH T 5 .   ? -11.887 -29.405 29.913  1.00 30.88 ? 580 HOH B O   1 
HETATM 7506 O  O   . HOH T 5 .   ? -8.394  -14.414 23.105  1.00 46.56 ? 581 HOH B O   1 
HETATM 7507 O  O   . HOH T 5 .   ? -6.980  -7.827  19.701  1.00 21.72 ? 582 HOH B O   1 
HETATM 7508 O  O   . HOH T 5 .   ? -34.101 -11.636 29.262  1.00 31.79 ? 583 HOH B O   1 
HETATM 7509 O  O   . HOH T 5 .   ? -27.377 -1.554  23.909  1.00 22.05 ? 584 HOH B O   1 
HETATM 7510 O  O   . HOH T 5 .   ? -35.776 -6.531  23.929  1.00 31.94 ? 585 HOH B O   1 
HETATM 7511 O  O   . HOH T 5 .   ? -25.489 -19.268 4.743   1.00 26.08 ? 586 HOH B O   1 
HETATM 7512 O  O   . HOH T 5 .   ? -8.748  -13.060 26.314  1.00 27.08 ? 587 HOH B O   1 
HETATM 7513 O  O   . HOH T 5 .   ? -21.774 -35.985 16.315  1.00 37.45 ? 588 HOH B O   1 
HETATM 7514 O  O   . HOH T 5 .   ? -32.028 -12.550 27.404  1.00 30.74 ? 589 HOH B O   1 
HETATM 7515 O  O   . HOH T 5 .   ? -30.629 -18.141 3.902   1.00 35.28 ? 590 HOH B O   1 
HETATM 7516 O  O   . HOH T 5 .   ? -17.017 -34.581 17.179  1.00 32.76 ? 591 HOH B O   1 
HETATM 7517 O  O   . HOH T 5 .   ? -24.197 -30.633 3.991   1.00 44.89 ? 592 HOH B O   1 
HETATM 7518 O  O   . HOH T 5 .   ? -31.537 -5.574  9.593   1.00 33.32 ? 593 HOH B O   1 
HETATM 7519 O  O   . HOH T 5 .   ? -18.735 -32.586 -16.694 1.00 31.58 ? 594 HOH B O   1 
HETATM 7520 O  O   . HOH T 5 .   ? -23.749 -8.700  7.228   1.00 15.20 ? 595 HOH B O   1 
HETATM 7521 O  O   . HOH T 5 .   ? -37.261 -23.015 43.044  1.00 35.04 ? 596 HOH B O   1 
HETATM 7522 O  O   . HOH T 5 .   ? -23.636 -4.934  13.415  1.00 41.86 ? 597 HOH B O   1 
HETATM 7523 O  O   . HOH T 5 .   ? -13.031 -2.755  11.871  1.00 24.72 ? 598 HOH B O   1 
HETATM 7524 O  O   . HOH T 5 .   ? -5.119  -7.748  18.589  1.00 33.52 ? 599 HOH B O   1 
HETATM 7525 O  O   . HOH T 5 .   ? -23.786 -34.590 -11.294 1.00 48.06 ? 600 HOH B O   1 
HETATM 7526 O  O   . HOH T 5 .   ? -38.327 -7.951  7.579   1.00 45.59 ? 601 HOH B O   1 
HETATM 7527 O  O   . HOH T 5 .   ? -10.250 -0.507  25.023  1.00 26.91 ? 602 HOH B O   1 
HETATM 7528 O  O   . HOH T 5 .   ? -5.892  -12.947 7.205   1.00 44.73 ? 603 HOH B O   1 
HETATM 7529 O  O   . HOH T 5 .   ? -26.499 -22.727 -0.860  1.00 37.02 ? 604 HOH B O   1 
HETATM 7530 O  O   . HOH T 5 .   ? -20.071 -5.887  6.962   1.00 15.04 ? 605 HOH B O   1 
HETATM 7531 O  O   . HOH T 5 .   ? -6.973  -12.617 23.211  1.00 25.33 ? 606 HOH B O   1 
HETATM 7532 O  O   . HOH T 5 .   ? -22.632 -6.328  6.530   1.00 20.12 ? 607 HOH B O   1 
HETATM 7533 O  O   . HOH T 5 .   ? -33.337 -10.521 31.041  1.00 41.38 ? 608 HOH B O   1 
HETATM 7534 O  O   . HOH T 5 .   ? -4.668  -8.280  12.520  1.00 41.44 ? 609 HOH B O   1 
HETATM 7535 O  O   . HOH T 5 .   ? -5.749  -20.913 26.876  1.00 35.08 ? 610 HOH B O   1 
HETATM 7536 O  O   . HOH T 5 .   ? -8.600  -22.416 11.095  1.00 32.91 ? 611 HOH B O   1 
HETATM 7537 O  O   . HOH T 5 .   ? -25.313 -5.350  10.474  1.00 39.29 ? 612 HOH B O   1 
HETATM 7538 O  O   . HOH U 5 .   ? -31.581 -16.200 -4.606  1.00 29.53 ? 501 HOH C O   1 
HETATM 7539 O  O   . HOH U 5 .   ? -30.060 1.959   0.108   1.00 37.23 ? 502 HOH C O   1 
HETATM 7540 O  O   . HOH U 5 .   ? -14.203 -11.418 -26.883 1.00 29.73 ? 503 HOH C O   1 
HETATM 7541 O  O   . HOH U 5 .   ? -31.640 -20.216 -14.222 1.00 18.47 ? 504 HOH C O   1 
HETATM 7542 O  O   . HOH U 5 .   ? -23.380 -16.887 -35.317 1.00 46.82 ? 505 HOH C O   1 
HETATM 7543 O  O   . HOH U 5 .   ? -8.466  -23.536 -16.836 1.00 29.16 ? 506 HOH C O   1 
HETATM 7544 O  O   . HOH U 5 .   ? -24.063 -19.184 -26.889 1.00 30.23 ? 507 HOH C O   1 
HETATM 7545 O  O   . HOH U 5 .   ? -23.488 -4.955  -34.370 1.00 30.76 ? 508 HOH C O   1 
HETATM 7546 O  O   . HOH U 5 .   ? -26.173 -18.174 -8.678  1.00 16.91 ? 509 HOH C O   1 
HETATM 7547 O  O   . HOH U 5 .   ? -29.188 -21.755 -26.717 1.00 28.95 ? 510 HOH C O   1 
HETATM 7548 O  O   . HOH U 5 .   ? -32.708 -9.608  -7.759  1.00 21.29 ? 511 HOH C O   1 
HETATM 7549 O  O   . HOH U 5 .   ? -8.008  -1.990  -6.727  1.00 20.29 ? 512 HOH C O   1 
HETATM 7550 O  O   . HOH U 5 .   ? -35.369 -7.831  -9.768  1.00 19.99 ? 513 HOH C O   1 
HETATM 7551 O  O   . HOH U 5 .   ? -17.174 -27.848 -21.550 1.00 34.38 ? 514 HOH C O   1 
HETATM 7552 O  O   . HOH U 5 .   ? -34.699 -17.104 -10.433 1.00 27.29 ? 515 HOH C O   1 
HETATM 7553 O  O   . HOH U 5 .   ? -32.320 10.904  -15.021 1.00 28.73 ? 516 HOH C O   1 
HETATM 7554 O  O   . HOH U 5 .   ? -36.878 -16.591 -18.712 1.00 24.54 ? 517 HOH C O   1 
HETATM 7555 O  O   . HOH U 5 .   ? -25.409 -28.175 -19.523 1.00 24.59 ? 518 HOH C O   1 
HETATM 7556 O  O   . HOH U 5 .   ? -27.728 -8.387  -32.561 1.00 31.02 ? 519 HOH C O   1 
HETATM 7557 O  O   . HOH U 5 .   ? -11.821 -15.940 -13.973 1.00 15.12 ? 520 HOH C O   1 
HETATM 7558 O  O   . HOH U 5 .   ? -17.836 -4.874  5.292   1.00 17.34 ? 521 HOH C O   1 
HETATM 7559 O  O   . HOH U 5 .   ? -30.646 -6.531  -2.362  1.00 16.05 ? 522 HOH C O   1 
HETATM 7560 O  O   . HOH U 5 .   ? -29.764 -9.282  -2.434  1.00 17.73 ? 523 HOH C O   1 
HETATM 7561 O  O   . HOH U 5 .   ? -28.428 -18.832 -11.452 1.00 22.28 ? 524 HOH C O   1 
HETATM 7562 O  O   . HOH U 5 .   ? -27.136 -23.919 -3.376  1.00 30.91 ? 525 HOH C O   1 
HETATM 7563 O  O   . HOH U 5 .   ? -29.868 -25.444 -10.659 1.00 29.33 ? 526 HOH C O   1 
HETATM 7564 O  O   . HOH U 5 .   ? -8.651  -5.784  1.987   1.00 19.39 ? 527 HOH C O   1 
HETATM 7565 O  O   . HOH U 5 .   ? -27.720 7.817   -2.174  1.00 35.50 ? 528 HOH C O   1 
HETATM 7566 O  O   . HOH U 5 .   ? -8.313  -2.197  -4.110  1.00 18.67 ? 529 HOH C O   1 
HETATM 7567 O  O   . HOH U 5 .   ? -17.556 -9.748  7.500   1.00 20.41 ? 530 HOH C O   1 
HETATM 7568 O  O   . HOH U 5 .   ? -33.861 -14.003 -31.525 1.00 31.38 ? 531 HOH C O   1 
HETATM 7569 O  O   . HOH U 5 .   ? -39.000 1.475   -17.040 1.00 34.86 ? 532 HOH C O   1 
HETATM 7570 O  O   . HOH U 5 .   ? -12.091 -18.361 -7.212  1.00 26.13 ? 533 HOH C O   1 
HETATM 7571 O  O   . HOH U 5 .   ? -4.436  -0.626  2.826   1.00 31.32 ? 534 HOH C O   1 
HETATM 7572 O  O   . HOH U 5 .   ? -12.146 -11.387 -24.255 1.00 28.05 ? 535 HOH C O   1 
HETATM 7573 O  O   . HOH U 5 .   ? -21.453 -21.221 -24.296 1.00 25.09 ? 536 HOH C O   1 
HETATM 7574 O  O   . HOH U 5 .   ? -15.096 7.131   -8.631  1.00 21.23 ? 537 HOH C O   1 
HETATM 7575 O  O   . HOH U 5 .   ? -18.018 -7.303  -34.915 1.00 33.37 ? 538 HOH C O   1 
HETATM 7576 O  O   . HOH U 5 .   ? -24.216 -6.517  4.795   1.00 37.45 ? 539 HOH C O   1 
HETATM 7577 O  O   . HOH U 5 .   ? -18.133 6.981   -4.332  1.00 26.92 ? 540 HOH C O   1 
HETATM 7578 O  O   . HOH U 5 .   ? -6.018  -5.723  -24.821 1.00 26.41 ? 541 HOH C O   1 
HETATM 7579 O  O   . HOH U 5 .   ? -3.547  -7.895  -3.251  1.00 33.52 ? 542 HOH C O   1 
HETATM 7580 O  O   . HOH U 5 .   ? -35.760 -7.542  -34.341 1.00 40.59 ? 543 HOH C O   1 
HETATM 7581 O  O   . HOH U 5 .   ? -14.444 -7.459  4.699   1.00 27.80 ? 544 HOH C O   1 
HETATM 7582 O  O   . HOH U 5 .   ? -14.710 -5.339  2.974   1.00 12.09 ? 545 HOH C O   1 
HETATM 7583 O  O   . HOH U 5 .   ? -23.395 -13.419 3.273   1.00 18.24 ? 546 HOH C O   1 
HETATM 7584 O  O   . HOH U 5 .   ? -3.596  -5.398  -0.063  1.00 35.62 ? 547 HOH C O   1 
HETATM 7585 O  O   . HOH U 5 .   ? -36.802 6.528   -8.272  1.00 26.56 ? 548 HOH C O   1 
HETATM 7586 O  O   . HOH U 5 .   ? -20.774 -10.960 -29.841 1.00 27.45 ? 549 HOH C O   1 
HETATM 7587 O  O   . HOH U 5 .   ? -38.257 -8.773  -2.989  1.00 34.91 ? 550 HOH C O   1 
HETATM 7588 O  O   . HOH U 5 .   ? -11.979 -11.486 8.683   1.00 14.70 ? 551 HOH C O   1 
HETATM 7589 O  O   . HOH U 5 .   ? -14.941 5.302   -15.600 1.00 26.72 ? 552 HOH C O   1 
HETATM 7590 O  O   . HOH U 5 .   ? -34.703 -11.166 -9.598  1.00 25.24 ? 553 HOH C O   1 
HETATM 7591 O  O   . HOH U 5 .   ? -18.271 -2.207  4.931   1.00 15.23 ? 554 HOH C O   1 
HETATM 7592 O  O   . HOH U 5 .   ? -31.963 -2.091  -12.821 1.00 20.36 ? 555 HOH C O   1 
HETATM 7593 O  O   . HOH U 5 .   ? -10.685 -16.334 0.982   1.00 28.06 ? 556 HOH C O   1 
HETATM 7594 O  O   . HOH U 5 .   ? -13.640 8.041   -2.775  1.00 29.21 ? 557 HOH C O   1 
HETATM 7595 O  O   . HOH U 5 .   ? -24.242 -2.088  -21.016 1.00 19.69 ? 558 HOH C O   1 
HETATM 7596 O  O   . HOH U 5 .   ? -16.969 1.758   -24.875 1.00 23.99 ? 559 HOH C O   1 
HETATM 7597 O  O   . HOH U 5 .   ? -38.738 -9.821  -26.644 1.00 49.31 ? 560 HOH C O   1 
HETATM 7598 O  O   . HOH U 5 .   ? -15.928 2.590   -27.469 1.00 25.47 ? 561 HOH C O   1 
HETATM 7599 O  O   . HOH U 5 .   ? -6.673  -4.131  2.839   1.00 25.13 ? 562 HOH C O   1 
HETATM 7600 O  O   . HOH U 5 .   ? -15.001 -9.661  8.075   1.00 20.58 ? 563 HOH C O   1 
HETATM 7601 O  O   . HOH U 5 .   ? -38.048 -8.834  -10.215 1.00 22.52 ? 564 HOH C O   1 
HETATM 7602 O  O   . HOH U 5 .   ? -34.240 -14.605 -3.156  1.00 41.36 ? 565 HOH C O   1 
HETATM 7603 O  O   . HOH U 5 .   ? -28.433 8.878   -5.148  1.00 28.03 ? 566 HOH C O   1 
HETATM 7604 O  O   . HOH U 5 .   ? -12.952 -21.219 -8.916  1.00 25.73 ? 567 HOH C O   1 
HETATM 7605 O  O   . HOH U 5 .   ? -4.110  -9.397  -18.036 1.00 31.18 ? 568 HOH C O   1 
HETATM 7606 O  O   . HOH U 5 .   ? -7.579  -12.725 -17.776 1.00 29.11 ? 569 HOH C O   1 
HETATM 7607 O  O   . HOH U 5 .   ? -43.567 -8.449  -15.968 1.00 46.71 ? 570 HOH C O   1 
HETATM 7608 O  O   . HOH U 5 .   ? -32.080 -22.592 -10.965 1.00 23.10 ? 571 HOH C O   1 
HETATM 7609 O  O   . HOH U 5 .   ? -4.300  -4.784  -8.928  1.00 22.97 ? 572 HOH C O   1 
HETATM 7610 O  O   . HOH U 5 .   ? -1.469  -3.129  -22.260 1.00 39.83 ? 573 HOH C O   1 
HETATM 7611 O  O   . HOH U 5 .   ? -28.631 16.543  -17.332 1.00 43.47 ? 574 HOH C O   1 
HETATM 7612 O  O   . HOH U 5 .   ? -12.813 11.609  -9.888  1.00 41.90 ? 575 HOH C O   1 
HETATM 7613 O  O   . HOH U 5 .   ? -12.155 -13.769 -23.232 1.00 21.00 ? 576 HOH C O   1 
HETATM 7614 O  O   . HOH U 5 .   ? -8.354  0.677   -9.623  1.00 27.46 ? 577 HOH C O   1 
HETATM 7615 O  O   . HOH U 5 .   ? -11.613 -23.441 -18.229 1.00 27.15 ? 578 HOH C O   1 
HETATM 7616 O  O   . HOH U 5 .   ? -25.539 -15.003 2.721   1.00 14.56 ? 579 HOH C O   1 
HETATM 7617 O  O   . HOH U 5 .   ? -24.324 -0.083  4.291   1.00 21.85 ? 580 HOH C O   1 
HETATM 7618 O  O   . HOH U 5 .   ? -14.844 5.137   -18.685 1.00 28.77 ? 581 HOH C O   1 
HETATM 7619 O  O   . HOH U 5 .   ? -24.329 -23.805 -27.745 1.00 31.08 ? 582 HOH C O   1 
HETATM 7620 O  O   . HOH U 5 .   ? -30.335 -8.577  5.306   1.00 29.13 ? 583 HOH C O   1 
HETATM 7621 O  O   . HOH U 5 .   ? -2.979  -2.937  -17.459 1.00 34.96 ? 584 HOH C O   1 
HETATM 7622 O  O   . HOH U 5 .   ? -12.706 3.441   -15.851 1.00 19.94 ? 585 HOH C O   1 
HETATM 7623 O  O   . HOH U 5 .   ? -28.151 -20.224 -0.948  1.00 47.49 ? 586 HOH C O   1 
HETATM 7624 O  O   . HOH U 5 .   ? -27.722 -8.576  6.770   1.00 37.50 ? 587 HOH C O   1 
HETATM 7625 O  O   . HOH U 5 .   ? -20.095 10.862  -2.985  1.00 28.24 ? 588 HOH C O   1 
HETATM 7626 O  O   . HOH U 5 .   ? -36.983 -12.590 -9.661  1.00 30.47 ? 589 HOH C O   1 
HETATM 7627 O  O   . HOH U 5 .   ? -8.671  -21.953 -10.033 1.00 41.01 ? 590 HOH C O   1 
HETATM 7628 O  O   . HOH U 5 .   ? -38.617 -14.878 -10.760 1.00 31.15 ? 591 HOH C O   1 
HETATM 7629 O  O   . HOH U 5 .   ? -9.377  -14.948 -14.068 1.00 24.56 ? 592 HOH C O   1 
HETATM 7630 O  O   . HOH U 5 .   ? -6.569  -20.003 5.182   1.00 45.63 ? 593 HOH C O   1 
HETATM 7631 O  O   . HOH U 5 .   ? -6.041  -11.685 4.137   1.00 38.12 ? 594 HOH C O   1 
HETATM 7632 O  O   . HOH U 5 .   ? -32.142 -14.361 2.001   1.00 25.04 ? 595 HOH C O   1 
HETATM 7633 O  O   . HOH U 5 .   ? -11.020 -23.299 -9.605  1.00 28.72 ? 596 HOH C O   1 
HETATM 7634 O  O   . HOH U 5 .   ? -21.710 1.060   4.432   1.00 17.53 ? 597 HOH C O   1 
HETATM 7635 O  O   . HOH U 5 .   ? -33.479 10.492  -17.839 1.00 34.18 ? 598 HOH C O   1 
HETATM 7636 O  O   . HOH U 5 .   ? -24.539 10.378  -3.066  1.00 30.98 ? 599 HOH C O   1 
HETATM 7637 O  O   . HOH U 5 .   ? -40.579 -7.405  -20.692 1.00 38.63 ? 600 HOH C O   1 
HETATM 7638 O  O   . HOH U 5 .   ? -34.014 -27.229 -23.494 1.00 40.08 ? 601 HOH C O   1 
HETATM 7639 O  O   . HOH U 5 .   ? -24.479 -27.793 -28.234 1.00 39.08 ? 602 HOH C O   1 
HETATM 7640 O  O   . HOH U 5 .   ? -13.230 -18.587 -4.338  1.00 35.63 ? 603 HOH C O   1 
HETATM 7641 O  O   . HOH U 5 .   ? -5.161  0.531   -15.494 1.00 35.96 ? 604 HOH C O   1 
HETATM 7642 O  O   . HOH U 5 .   ? -8.283  -16.284 1.669   1.00 35.81 ? 605 HOH C O   1 
HETATM 7643 O  O   . HOH U 5 .   ? -12.031 -20.120 2.464   1.00 50.06 ? 606 HOH C O   1 
HETATM 7644 O  O   . HOH U 5 .   ? -42.662 5.518   1.946   1.00 32.01 ? 607 HOH C O   1 
HETATM 7645 O  O   . HOH U 5 .   ? -19.844 8.397   -3.524  1.00 27.93 ? 608 HOH C O   1 
HETATM 7646 O  O   . HOH U 5 .   ? -29.342 -28.650 -28.914 1.00 46.06 ? 609 HOH C O   1 
HETATM 7647 O  O   . HOH U 5 .   ? -17.160 -26.014 -25.766 1.00 35.43 ? 610 HOH C O   1 
HETATM 7648 O  O   . HOH U 5 .   ? -45.216 -7.698  -8.526  1.00 44.91 ? 611 HOH C O   1 
HETATM 7649 O  O   . HOH U 5 .   ? -35.131 -1.976  3.978   1.00 41.71 ? 612 HOH C O   1 
HETATM 7650 O  O   . HOH U 5 .   ? -42.372 -11.553 -16.412 1.00 45.03 ? 613 HOH C O   1 
HETATM 7651 O  O   . HOH U 5 .   ? -27.219 -20.127 -27.735 1.00 35.77 ? 614 HOH C O   1 
HETATM 7652 O  O   . HOH U 5 .   ? -32.061 -19.632 -2.348  1.00 38.90 ? 615 HOH C O   1 
HETATM 7653 O  O   . HOH U 5 .   ? -11.472 -20.190 -24.632 1.00 41.64 ? 616 HOH C O   1 
HETATM 7654 O  O   . HOH U 5 .   ? -13.833 -24.231 -25.348 1.00 43.44 ? 617 HOH C O   1 
HETATM 7655 O  O   . HOH U 5 .   ? -3.472  -4.841  -11.755 1.00 41.29 ? 618 HOH C O   1 
HETATM 7656 O  O   . HOH U 5 .   ? -21.621 -11.295 -32.294 1.00 35.41 ? 619 HOH C O   1 
HETATM 7657 O  O   . HOH U 5 .   ? -34.369 -28.234 -21.039 1.00 49.96 ? 620 HOH C O   1 
HETATM 7658 O  O   . HOH U 5 .   ? -28.884 5.589   -1.136  1.00 34.92 ? 621 HOH C O   1 
HETATM 7659 O  O   . HOH U 5 .   ? -19.115 -1.535  7.438   1.00 17.99 ? 622 HOH C O   1 
HETATM 7660 O  O   . HOH U 5 .   ? -6.309  -21.505 -11.660 1.00 41.57 ? 623 HOH C O   1 
HETATM 7661 O  O   . HOH U 5 .   ? -17.996 -22.364 3.782   1.00 31.17 ? 624 HOH C O   1 
HETATM 7662 O  O   . HOH U 5 .   ? -2.526  -8.345  -6.176  1.00 38.22 ? 625 HOH C O   1 
HETATM 7663 O  O   . HOH U 5 .   ? -32.028 -16.579 -0.285  1.00 37.65 ? 626 HOH C O   1 
HETATM 7664 O  O   . HOH U 5 .   ? -23.037 -21.656 -26.481 1.00 33.15 ? 627 HOH C O   1 
HETATM 7665 O  O   . HOH U 5 .   ? -25.488 -3.768  5.035   1.00 45.91 ? 628 HOH C O   1 
HETATM 7666 O  O   . HOH U 5 .   ? -21.326 0.118   6.997   1.00 18.25 ? 629 HOH C O   1 
HETATM 7667 O  O   . HOH U 5 .   ? -32.975 -8.302  4.799   1.00 38.80 ? 630 HOH C O   1 
HETATM 7668 O  O   . HOH U 5 .   ? -3.377  -5.830  -25.734 1.00 47.17 ? 631 HOH C O   1 
HETATM 7669 O  O   . HOH U 5 .   ? -29.858 2.223   4.077   1.00 53.57 ? 632 HOH C O   1 
HETATM 7670 O  O   . HOH U 5 .   ? -29.455 14.866  -19.480 1.00 42.90 ? 633 HOH C O   1 
HETATM 7671 O  O   . HOH U 5 .   ? -5.690  -2.511  -8.033  1.00 27.20 ? 634 HOH C O   1 
HETATM 7672 O  O   . HOH U 5 .   ? -7.482  -16.616 -14.000 1.00 28.65 ? 635 HOH C O   1 
HETATM 7673 O  O   . HOH U 5 .   ? -23.055 -1.818  8.144   1.00 51.52 ? 636 HOH C O   1 
# 
