data_8RBC
# 
_entry.id   8RBC 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.400 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8RBC         pdb_00008rbc 10.2210/pdb8rbc/pdb 
WWPDB D_1292135042 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2024-11-27 
2 'Structure model' 1 1 2025-01-01 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
_pdbx_audit_revision_category.ordinal             1 
_pdbx_audit_revision_category.revision_ordinal    2 
_pdbx_audit_revision_category.data_content_type   'Structure model' 
_pdbx_audit_revision_category.category            citation 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
5 2 'Structure model' '_citation.title'                   
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8RBC 
_pdbx_database_status.recvd_initial_deposition_date   2023-12-04 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_database_related.content_type 
_pdbx_database_related.db_id 
_pdbx_database_related.db_name 
_pdbx_database_related.details 
unspecified 8RBA PDB . 
unspecified 8RBB PDB . 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              frank.boeckler@uni-tuebingen.de 
_pdbx_contact_author.name_first         Frank 
_pdbx_contact_author.name_last          Boeckler 
_pdbx_contact_author.name_mi            M 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-8738-6716 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Stahlecker, J.' 1 0000-0002-0044-4037 
'Klett, T.'      2 0000-0003-4049-9363 
'Stehle, T.'     3 0000-0002-4571-8548 
'Boeckler, F.M.' 4 0000-0001-8738-6716 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Acs Pharmacol Transl Sci' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2575-910 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            7 
_citation.language                  ? 
_citation.page_first                3984 
_citation.page_last                 3999 
_citation.title                     
'Covalent Fragments Acting as Tyrosine Mimics for Mutant p53-Y220C Rescue by Nucleophilic Aromatic Substitution.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/acsptsci.4c00414 
_citation.pdbx_database_id_PubMed   39698266 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Klett, T.'       1 ? 
primary 'Stahlecker, J.'  2 ? 
primary 'Jaag, S.'        3 ? 
primary 'Masberg, B.'     4 ? 
primary 'Knappe, C.'      5 ? 
primary 'Lammerhofer, M.' 6 ? 
primary 'Coles, M.'       7 ? 
primary 'Stehle, T.'      8 ? 
primary 'Boeckler, F.M.'  9 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Cellular tumor antigen p53'                          24530.811 2   ? ? ? ? 
2 non-polymer nat 3-azanylpyrazine-2,6-dicarbonitrile                   145.122   3   ? ? ? ? 
3 non-polymer syn '4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID' 238.305   3   ? ? ? ? 
4 non-polymer nat 'DI(HYDROXYETHYL)ETHER'                               106.120   1   ? ? ? ? 
5 non-polymer nat 'ZINC ION'                                            65.409    2   ? ? ? ? 
6 water       nat water                                                 18.015    157 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;SSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKLFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVV
RRCPHHERCSDSDGLAPPQHLIRVEGNLRAEYLDDRNTFRHSVVVPCEPPEVGSDCTTIHYNYMCYSSCMGGMNRRPILT
IITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNT
;
_entity_poly.pdbx_seq_one_letter_code_can   
;SSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKLFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVV
RRCPHHERCSDSDGLAPPQHLIRVEGNLRAEYLDDRNTFRHSVVVPCEPPEVGSDCTTIHYNYMCYSSCMGGMNRRPILT
IITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNT
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 3-azanylpyrazine-2,6-dicarbonitrile                   YM0 
3 '4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID' EPE 
4 'DI(HYDROXYETHYL)ETHER'                               PEG 
5 'ZINC ION'                                            ZN  
6 water                                                 HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   SER n 
1 3   SER n 
1 4   VAL n 
1 5   PRO n 
1 6   SER n 
1 7   GLN n 
1 8   LYS n 
1 9   THR n 
1 10  TYR n 
1 11  GLN n 
1 12  GLY n 
1 13  SER n 
1 14  TYR n 
1 15  GLY n 
1 16  PHE n 
1 17  ARG n 
1 18  LEU n 
1 19  GLY n 
1 20  PHE n 
1 21  LEU n 
1 22  HIS n 
1 23  SER n 
1 24  GLY n 
1 25  THR n 
1 26  ALA n 
1 27  LYS n 
1 28  SER n 
1 29  VAL n 
1 30  THR n 
1 31  CYS n 
1 32  THR n 
1 33  TYR n 
1 34  SER n 
1 35  PRO n 
1 36  ALA n 
1 37  LEU n 
1 38  ASN n 
1 39  LYS n 
1 40  LEU n 
1 41  PHE n 
1 42  CYS n 
1 43  GLN n 
1 44  LEU n 
1 45  ALA n 
1 46  LYS n 
1 47  THR n 
1 48  CYS n 
1 49  PRO n 
1 50  VAL n 
1 51  GLN n 
1 52  LEU n 
1 53  TRP n 
1 54  VAL n 
1 55  ASP n 
1 56  SER n 
1 57  THR n 
1 58  PRO n 
1 59  PRO n 
1 60  PRO n 
1 61  GLY n 
1 62  THR n 
1 63  ARG n 
1 64  VAL n 
1 65  ARG n 
1 66  ALA n 
1 67  MET n 
1 68  ALA n 
1 69  ILE n 
1 70  TYR n 
1 71  LYS n 
1 72  GLN n 
1 73  SER n 
1 74  GLN n 
1 75  HIS n 
1 76  MET n 
1 77  THR n 
1 78  GLU n 
1 79  VAL n 
1 80  VAL n 
1 81  ARG n 
1 82  ARG n 
1 83  CYS n 
1 84  PRO n 
1 85  HIS n 
1 86  HIS n 
1 87  GLU n 
1 88  ARG n 
1 89  CYS n 
1 90  SER n 
1 91  ASP n 
1 92  SER n 
1 93  ASP n 
1 94  GLY n 
1 95  LEU n 
1 96  ALA n 
1 97  PRO n 
1 98  PRO n 
1 99  GLN n 
1 100 HIS n 
1 101 LEU n 
1 102 ILE n 
1 103 ARG n 
1 104 VAL n 
1 105 GLU n 
1 106 GLY n 
1 107 ASN n 
1 108 LEU n 
1 109 ARG n 
1 110 ALA n 
1 111 GLU n 
1 112 TYR n 
1 113 LEU n 
1 114 ASP n 
1 115 ASP n 
1 116 ARG n 
1 117 ASN n 
1 118 THR n 
1 119 PHE n 
1 120 ARG n 
1 121 HIS n 
1 122 SER n 
1 123 VAL n 
1 124 VAL n 
1 125 VAL n 
1 126 PRO n 
1 127 CYS n 
1 128 GLU n 
1 129 PRO n 
1 130 PRO n 
1 131 GLU n 
1 132 VAL n 
1 133 GLY n 
1 134 SER n 
1 135 ASP n 
1 136 CYS n 
1 137 THR n 
1 138 THR n 
1 139 ILE n 
1 140 HIS n 
1 141 TYR n 
1 142 ASN n 
1 143 TYR n 
1 144 MET n 
1 145 CYS n 
1 146 TYR n 
1 147 SER n 
1 148 SER n 
1 149 CYS n 
1 150 MET n 
1 151 GLY n 
1 152 GLY n 
1 153 MET n 
1 154 ASN n 
1 155 ARG n 
1 156 ARG n 
1 157 PRO n 
1 158 ILE n 
1 159 LEU n 
1 160 THR n 
1 161 ILE n 
1 162 ILE n 
1 163 THR n 
1 164 LEU n 
1 165 GLU n 
1 166 ASP n 
1 167 SER n 
1 168 SER n 
1 169 GLY n 
1 170 ASN n 
1 171 LEU n 
1 172 LEU n 
1 173 GLY n 
1 174 ARG n 
1 175 ASP n 
1 176 SER n 
1 177 PHE n 
1 178 GLU n 
1 179 VAL n 
1 180 ARG n 
1 181 VAL n 
1 182 CYS n 
1 183 ALA n 
1 184 CYS n 
1 185 PRO n 
1 186 GLY n 
1 187 ARG n 
1 188 ASP n 
1 189 ARG n 
1 190 ARG n 
1 191 THR n 
1 192 GLU n 
1 193 GLU n 
1 194 GLU n 
1 195 ASN n 
1 196 LEU n 
1 197 ARG n 
1 198 LYS n 
1 199 LYS n 
1 200 GLY n 
1 201 GLU n 
1 202 PRO n 
1 203 HIS n 
1 204 HIS n 
1 205 GLU n 
1 206 LEU n 
1 207 PRO n 
1 208 PRO n 
1 209 GLY n 
1 210 SER n 
1 211 THR n 
1 212 LYS n 
1 213 ARG n 
1 214 ALA n 
1 215 LEU n 
1 216 PRO n 
1 217 ASN n 
1 218 ASN n 
1 219 THR n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   219 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'TP53, P53' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                               ?     'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                                              ?     'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                                            ?     'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                       ?     'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE                                              ?     'C3 H7 N O2 S'   121.158 
EPE non-polymer         . '4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID' HEPES 'C8 H18 N2 O4 S' 238.305 
GLN 'L-peptide linking' y GLUTAMINE                                             ?     'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                       ?     'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                                               ?     'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                                             ?     'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                                                 ?     'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                            ?     'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                                               ?     'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                                                ?     'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE                                            ?     'C5 H11 N O2 S'  149.211 
PEG non-polymer         . 'DI(HYDROXYETHYL)ETHER'                               ?     'C4 H10 O3'      106.120 
PHE 'L-peptide linking' y PHENYLALANINE                                         ?     'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE                                               ?     'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                                                ?     'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                                             ?     'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                            ?     'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                                              ?     'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                                                ?     'C5 H11 N O2'    117.146 
YM0 non-polymer         . 3-azanylpyrazine-2,6-dicarbonitrile                   ?     'C6 H3 N5'       145.122 
ZN  non-polymer         . 'ZINC ION'                                            ?     'Zn 2'           65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   94  ?   ?   ?   A . n 
A 1 2   SER 2   95  95  SER SER A . n 
A 1 3   SER 3   96  96  SER SER A . n 
A 1 4   VAL 4   97  97  VAL VAL A . n 
A 1 5   PRO 5   98  98  PRO PRO A . n 
A 1 6   SER 6   99  99  SER SER A . n 
A 1 7   GLN 7   100 100 GLN GLN A . n 
A 1 8   LYS 8   101 101 LYS LYS A . n 
A 1 9   THR 9   102 102 THR THR A . n 
A 1 10  TYR 10  103 103 TYR TYR A . n 
A 1 11  GLN 11  104 104 GLN GLN A . n 
A 1 12  GLY 12  105 105 GLY GLY A . n 
A 1 13  SER 13  106 106 SER SER A . n 
A 1 14  TYR 14  107 107 TYR TYR A . n 
A 1 15  GLY 15  108 108 GLY GLY A . n 
A 1 16  PHE 16  109 109 PHE PHE A . n 
A 1 17  ARG 17  110 110 ARG ARG A . n 
A 1 18  LEU 18  111 111 LEU LEU A . n 
A 1 19  GLY 19  112 112 GLY GLY A . n 
A 1 20  PHE 20  113 113 PHE PHE A . n 
A 1 21  LEU 21  114 114 LEU LEU A . n 
A 1 22  HIS 22  115 115 HIS HIS A . n 
A 1 23  SER 23  116 116 SER SER A . n 
A 1 24  GLY 24  117 117 GLY GLY A . n 
A 1 25  THR 25  118 118 THR THR A . n 
A 1 26  ALA 26  119 119 ALA ALA A . n 
A 1 27  LYS 27  120 120 LYS LYS A . n 
A 1 28  SER 28  121 121 SER SER A . n 
A 1 29  VAL 29  122 122 VAL VAL A . n 
A 1 30  THR 30  123 123 THR THR A . n 
A 1 31  CYS 31  124 124 CYS CYS A . n 
A 1 32  THR 32  125 125 THR THR A . n 
A 1 33  TYR 33  126 126 TYR TYR A . n 
A 1 34  SER 34  127 127 SER SER A . n 
A 1 35  PRO 35  128 128 PRO PRO A . n 
A 1 36  ALA 36  129 129 ALA ALA A . n 
A 1 37  LEU 37  130 130 LEU LEU A . n 
A 1 38  ASN 38  131 131 ASN ASN A . n 
A 1 39  LYS 39  132 132 LYS LYS A . n 
A 1 40  LEU 40  133 133 LEU LEU A . n 
A 1 41  PHE 41  134 134 PHE PHE A . n 
A 1 42  CYS 42  135 135 CYS CYS A . n 
A 1 43  GLN 43  136 136 GLN GLN A . n 
A 1 44  LEU 44  137 137 LEU LEU A . n 
A 1 45  ALA 45  138 138 ALA ALA A . n 
A 1 46  LYS 46  139 139 LYS LYS A . n 
A 1 47  THR 47  140 140 THR THR A . n 
A 1 48  CYS 48  141 141 CYS CYS A . n 
A 1 49  PRO 49  142 142 PRO PRO A . n 
A 1 50  VAL 50  143 143 VAL VAL A . n 
A 1 51  GLN 51  144 144 GLN GLN A . n 
A 1 52  LEU 52  145 145 LEU LEU A . n 
A 1 53  TRP 53  146 146 TRP TRP A . n 
A 1 54  VAL 54  147 147 VAL VAL A . n 
A 1 55  ASP 55  148 148 ASP ASP A . n 
A 1 56  SER 56  149 149 SER SER A . n 
A 1 57  THR 57  150 150 THR THR A . n 
A 1 58  PRO 58  151 151 PRO PRO A . n 
A 1 59  PRO 59  152 152 PRO PRO A . n 
A 1 60  PRO 60  153 153 PRO PRO A . n 
A 1 61  GLY 61  154 154 GLY GLY A . n 
A 1 62  THR 62  155 155 THR THR A . n 
A 1 63  ARG 63  156 156 ARG ARG A . n 
A 1 64  VAL 64  157 157 VAL VAL A . n 
A 1 65  ARG 65  158 158 ARG ARG A . n 
A 1 66  ALA 66  159 159 ALA ALA A . n 
A 1 67  MET 67  160 160 MET MET A . n 
A 1 68  ALA 68  161 161 ALA ALA A . n 
A 1 69  ILE 69  162 162 ILE ILE A . n 
A 1 70  TYR 70  163 163 TYR TYR A . n 
A 1 71  LYS 71  164 164 LYS LYS A . n 
A 1 72  GLN 72  165 165 GLN GLN A . n 
A 1 73  SER 73  166 166 SER SER A . n 
A 1 74  GLN 74  167 167 GLN GLN A . n 
A 1 75  HIS 75  168 168 HIS HIS A . n 
A 1 76  MET 76  169 169 MET MET A . n 
A 1 77  THR 77  170 170 THR THR A . n 
A 1 78  GLU 78  171 171 GLU GLU A . n 
A 1 79  VAL 79  172 172 VAL VAL A . n 
A 1 80  VAL 80  173 173 VAL VAL A . n 
A 1 81  ARG 81  174 174 ARG ARG A . n 
A 1 82  ARG 82  175 175 ARG ARG A . n 
A 1 83  CYS 83  176 176 CYS CYS A . n 
A 1 84  PRO 84  177 177 PRO PRO A . n 
A 1 85  HIS 85  178 178 HIS HIS A . n 
A 1 86  HIS 86  179 179 HIS HIS A . n 
A 1 87  GLU 87  180 180 GLU GLU A . n 
A 1 88  ARG 88  181 181 ARG ARG A . n 
A 1 89  CYS 89  182 182 CYS CYS A . n 
A 1 90  SER 90  183 183 SER SER A . n 
A 1 91  ASP 91  184 184 ASP ASP A . n 
A 1 92  SER 92  185 185 SER SER A . n 
A 1 93  ASP 93  186 186 ASP ASP A . n 
A 1 94  GLY 94  187 187 GLY GLY A . n 
A 1 95  LEU 95  188 188 LEU LEU A . n 
A 1 96  ALA 96  189 189 ALA ALA A . n 
A 1 97  PRO 97  190 190 PRO PRO A . n 
A 1 98  PRO 98  191 191 PRO PRO A . n 
A 1 99  GLN 99  192 192 GLN GLN A . n 
A 1 100 HIS 100 193 193 HIS HIS A . n 
A 1 101 LEU 101 194 194 LEU LEU A . n 
A 1 102 ILE 102 195 195 ILE ILE A . n 
A 1 103 ARG 103 196 196 ARG ARG A . n 
A 1 104 VAL 104 197 197 VAL VAL A . n 
A 1 105 GLU 105 198 198 GLU GLU A . n 
A 1 106 GLY 106 199 199 GLY GLY A . n 
A 1 107 ASN 107 200 200 ASN ASN A . n 
A 1 108 LEU 108 201 201 LEU LEU A . n 
A 1 109 ARG 109 202 202 ARG ARG A . n 
A 1 110 ALA 110 203 203 ALA ALA A . n 
A 1 111 GLU 111 204 204 GLU GLU A . n 
A 1 112 TYR 112 205 205 TYR TYR A . n 
A 1 113 LEU 113 206 206 LEU LEU A . n 
A 1 114 ASP 114 207 207 ASP ASP A . n 
A 1 115 ASP 115 208 208 ASP ASP A . n 
A 1 116 ARG 116 209 209 ARG ARG A . n 
A 1 117 ASN 117 210 210 ASN ASN A . n 
A 1 118 THR 118 211 211 THR THR A . n 
A 1 119 PHE 119 212 212 PHE PHE A . n 
A 1 120 ARG 120 213 213 ARG ARG A . n 
A 1 121 HIS 121 214 214 HIS HIS A . n 
A 1 122 SER 122 215 215 SER SER A . n 
A 1 123 VAL 123 216 216 VAL VAL A . n 
A 1 124 VAL 124 217 217 VAL VAL A . n 
A 1 125 VAL 125 218 218 VAL VAL A . n 
A 1 126 PRO 126 219 219 PRO PRO A . n 
A 1 127 CYS 127 220 220 CYS CYS A . n 
A 1 128 GLU 128 221 221 GLU GLU A . n 
A 1 129 PRO 129 222 222 PRO PRO A . n 
A 1 130 PRO 130 223 223 PRO PRO A . n 
A 1 131 GLU 131 224 224 GLU GLU A . n 
A 1 132 VAL 132 225 225 VAL VAL A . n 
A 1 133 GLY 133 226 226 GLY GLY A . n 
A 1 134 SER 134 227 227 SER SER A . n 
A 1 135 ASP 135 228 228 ASP ASP A . n 
A 1 136 CYS 136 229 229 CYS CYS A . n 
A 1 137 THR 137 230 230 THR THR A . n 
A 1 138 THR 138 231 231 THR THR A . n 
A 1 139 ILE 139 232 232 ILE ILE A . n 
A 1 140 HIS 140 233 233 HIS HIS A . n 
A 1 141 TYR 141 234 234 TYR TYR A . n 
A 1 142 ASN 142 235 235 ASN ASN A . n 
A 1 143 TYR 143 236 236 TYR TYR A . n 
A 1 144 MET 144 237 237 MET MET A . n 
A 1 145 CYS 145 238 238 CYS CYS A . n 
A 1 146 TYR 146 239 239 TYR TYR A . n 
A 1 147 SER 147 240 240 SER SER A . n 
A 1 148 SER 148 241 241 SER SER A . n 
A 1 149 CYS 149 242 242 CYS CYS A . n 
A 1 150 MET 150 243 243 MET MET A . n 
A 1 151 GLY 151 244 244 GLY GLY A . n 
A 1 152 GLY 152 245 245 GLY GLY A . n 
A 1 153 MET 153 246 246 MET MET A . n 
A 1 154 ASN 154 247 247 ASN ASN A . n 
A 1 155 ARG 155 248 248 ARG ARG A . n 
A 1 156 ARG 156 249 249 ARG ARG A . n 
A 1 157 PRO 157 250 250 PRO PRO A . n 
A 1 158 ILE 158 251 251 ILE ILE A . n 
A 1 159 LEU 159 252 252 LEU LEU A . n 
A 1 160 THR 160 253 253 THR THR A . n 
A 1 161 ILE 161 254 254 ILE ILE A . n 
A 1 162 ILE 162 255 255 ILE ILE A . n 
A 1 163 THR 163 256 256 THR THR A . n 
A 1 164 LEU 164 257 257 LEU LEU A . n 
A 1 165 GLU 165 258 258 GLU GLU A . n 
A 1 166 ASP 166 259 259 ASP ASP A . n 
A 1 167 SER 167 260 260 SER SER A . n 
A 1 168 SER 168 261 261 SER SER A . n 
A 1 169 GLY 169 262 262 GLY GLY A . n 
A 1 170 ASN 170 263 263 ASN ASN A . n 
A 1 171 LEU 171 264 264 LEU LEU A . n 
A 1 172 LEU 172 265 265 LEU LEU A . n 
A 1 173 GLY 173 266 266 GLY GLY A . n 
A 1 174 ARG 174 267 267 ARG ARG A . n 
A 1 175 ASP 175 268 268 ASP ASP A . n 
A 1 176 SER 176 269 269 SER SER A . n 
A 1 177 PHE 177 270 270 PHE PHE A . n 
A 1 178 GLU 178 271 271 GLU GLU A . n 
A 1 179 VAL 179 272 272 VAL VAL A . n 
A 1 180 ARG 180 273 273 ARG ARG A . n 
A 1 181 VAL 181 274 274 VAL VAL A . n 
A 1 182 CYS 182 275 275 CYS CYS A . n 
A 1 183 ALA 183 276 276 ALA ALA A . n 
A 1 184 CYS 184 277 277 CYS CYS A . n 
A 1 185 PRO 185 278 278 PRO PRO A . n 
A 1 186 GLY 186 279 279 GLY GLY A . n 
A 1 187 ARG 187 280 280 ARG ARG A . n 
A 1 188 ASP 188 281 281 ASP ASP A . n 
A 1 189 ARG 189 282 282 ARG ARG A . n 
A 1 190 ARG 190 283 283 ARG ARG A . n 
A 1 191 THR 191 284 284 THR THR A . n 
A 1 192 GLU 192 285 285 GLU GLU A . n 
A 1 193 GLU 193 286 286 GLU GLU A . n 
A 1 194 GLU 194 287 287 GLU GLU A . n 
A 1 195 ASN 195 288 288 ASN ASN A . n 
A 1 196 LEU 196 289 289 LEU LEU A . n 
A 1 197 ARG 197 290 290 ARG ARG A . n 
A 1 198 LYS 198 291 291 LYS LYS A . n 
A 1 199 LYS 199 292 ?   ?   ?   A . n 
A 1 200 GLY 200 293 ?   ?   ?   A . n 
A 1 201 GLU 201 294 ?   ?   ?   A . n 
A 1 202 PRO 202 295 ?   ?   ?   A . n 
A 1 203 HIS 203 296 ?   ?   ?   A . n 
A 1 204 HIS 204 297 ?   ?   ?   A . n 
A 1 205 GLU 205 298 ?   ?   ?   A . n 
A 1 206 LEU 206 299 ?   ?   ?   A . n 
A 1 207 PRO 207 300 ?   ?   ?   A . n 
A 1 208 PRO 208 301 ?   ?   ?   A . n 
A 1 209 GLY 209 302 ?   ?   ?   A . n 
A 1 210 SER 210 303 ?   ?   ?   A . n 
A 1 211 THR 211 304 ?   ?   ?   A . n 
A 1 212 LYS 212 305 ?   ?   ?   A . n 
A 1 213 ARG 213 306 ?   ?   ?   A . n 
A 1 214 ALA 214 307 ?   ?   ?   A . n 
A 1 215 LEU 215 308 ?   ?   ?   A . n 
A 1 216 PRO 216 309 ?   ?   ?   A . n 
A 1 217 ASN 217 310 ?   ?   ?   A . n 
A 1 218 ASN 218 311 ?   ?   ?   A . n 
A 1 219 THR 219 312 ?   ?   ?   A . n 
B 1 1   SER 1   94  ?   ?   ?   B . n 
B 1 2   SER 2   95  95  SER SER B . n 
B 1 3   SER 3   96  96  SER SER B . n 
B 1 4   VAL 4   97  97  VAL VAL B . n 
B 1 5   PRO 5   98  98  PRO PRO B . n 
B 1 6   SER 6   99  99  SER SER B . n 
B 1 7   GLN 7   100 100 GLN GLN B . n 
B 1 8   LYS 8   101 101 LYS LYS B . n 
B 1 9   THR 9   102 102 THR THR B . n 
B 1 10  TYR 10  103 103 TYR TYR B . n 
B 1 11  GLN 11  104 104 GLN GLN B . n 
B 1 12  GLY 12  105 105 GLY GLY B . n 
B 1 13  SER 13  106 106 SER SER B . n 
B 1 14  TYR 14  107 107 TYR TYR B . n 
B 1 15  GLY 15  108 108 GLY GLY B . n 
B 1 16  PHE 16  109 109 PHE PHE B . n 
B 1 17  ARG 17  110 110 ARG ARG B . n 
B 1 18  LEU 18  111 111 LEU LEU B . n 
B 1 19  GLY 19  112 112 GLY GLY B . n 
B 1 20  PHE 20  113 113 PHE PHE B . n 
B 1 21  LEU 21  114 114 LEU LEU B . n 
B 1 22  HIS 22  115 115 HIS HIS B . n 
B 1 23  SER 23  116 116 SER SER B . n 
B 1 24  GLY 24  117 117 GLY GLY B . n 
B 1 25  THR 25  118 118 THR THR B . n 
B 1 26  ALA 26  119 119 ALA ALA B . n 
B 1 27  LYS 27  120 120 LYS LYS B . n 
B 1 28  SER 28  121 121 SER SER B . n 
B 1 29  VAL 29  122 122 VAL VAL B . n 
B 1 30  THR 30  123 123 THR THR B . n 
B 1 31  CYS 31  124 124 CYS CYS B . n 
B 1 32  THR 32  125 125 THR THR B . n 
B 1 33  TYR 33  126 126 TYR TYR B . n 
B 1 34  SER 34  127 127 SER SER B . n 
B 1 35  PRO 35  128 128 PRO PRO B . n 
B 1 36  ALA 36  129 129 ALA ALA B . n 
B 1 37  LEU 37  130 130 LEU LEU B . n 
B 1 38  ASN 38  131 131 ASN ASN B . n 
B 1 39  LYS 39  132 132 LYS LYS B . n 
B 1 40  LEU 40  133 133 LEU LEU B . n 
B 1 41  PHE 41  134 134 PHE PHE B . n 
B 1 42  CYS 42  135 135 CYS CYS B . n 
B 1 43  GLN 43  136 136 GLN GLN B . n 
B 1 44  LEU 44  137 137 LEU LEU B . n 
B 1 45  ALA 45  138 138 ALA ALA B . n 
B 1 46  LYS 46  139 139 LYS LYS B . n 
B 1 47  THR 47  140 140 THR THR B . n 
B 1 48  CYS 48  141 141 CYS CYS B . n 
B 1 49  PRO 49  142 142 PRO PRO B . n 
B 1 50  VAL 50  143 143 VAL VAL B . n 
B 1 51  GLN 51  144 144 GLN GLN B . n 
B 1 52  LEU 52  145 145 LEU LEU B . n 
B 1 53  TRP 53  146 146 TRP TRP B . n 
B 1 54  VAL 54  147 147 VAL VAL B . n 
B 1 55  ASP 55  148 148 ASP ASP B . n 
B 1 56  SER 56  149 149 SER SER B . n 
B 1 57  THR 57  150 150 THR THR B . n 
B 1 58  PRO 58  151 151 PRO PRO B . n 
B 1 59  PRO 59  152 152 PRO PRO B . n 
B 1 60  PRO 60  153 153 PRO PRO B . n 
B 1 61  GLY 61  154 154 GLY GLY B . n 
B 1 62  THR 62  155 155 THR THR B . n 
B 1 63  ARG 63  156 156 ARG ARG B . n 
B 1 64  VAL 64  157 157 VAL VAL B . n 
B 1 65  ARG 65  158 158 ARG ARG B . n 
B 1 66  ALA 66  159 159 ALA ALA B . n 
B 1 67  MET 67  160 160 MET MET B . n 
B 1 68  ALA 68  161 161 ALA ALA B . n 
B 1 69  ILE 69  162 162 ILE ILE B . n 
B 1 70  TYR 70  163 163 TYR TYR B . n 
B 1 71  LYS 71  164 164 LYS LYS B . n 
B 1 72  GLN 72  165 165 GLN GLN B . n 
B 1 73  SER 73  166 166 SER SER B . n 
B 1 74  GLN 74  167 167 GLN GLN B . n 
B 1 75  HIS 75  168 168 HIS HIS B . n 
B 1 76  MET 76  169 169 MET MET B . n 
B 1 77  THR 77  170 170 THR THR B . n 
B 1 78  GLU 78  171 171 GLU GLU B . n 
B 1 79  VAL 79  172 172 VAL VAL B . n 
B 1 80  VAL 80  173 173 VAL VAL B . n 
B 1 81  ARG 81  174 174 ARG ARG B . n 
B 1 82  ARG 82  175 175 ARG ARG B . n 
B 1 83  CYS 83  176 176 CYS CYS B . n 
B 1 84  PRO 84  177 177 PRO PRO B . n 
B 1 85  HIS 85  178 178 HIS HIS B . n 
B 1 86  HIS 86  179 179 HIS HIS B . n 
B 1 87  GLU 87  180 180 GLU GLU B . n 
B 1 88  ARG 88  181 181 ARG ARG B . n 
B 1 89  CYS 89  182 182 CYS CYS B . n 
B 1 90  SER 90  183 183 SER SER B . n 
B 1 91  ASP 91  184 184 ASP ASP B . n 
B 1 92  SER 92  185 185 SER SER B . n 
B 1 93  ASP 93  186 186 ASP ASP B . n 
B 1 94  GLY 94  187 187 GLY GLY B . n 
B 1 95  LEU 95  188 188 LEU LEU B . n 
B 1 96  ALA 96  189 189 ALA ALA B . n 
B 1 97  PRO 97  190 190 PRO PRO B . n 
B 1 98  PRO 98  191 191 PRO PRO B . n 
B 1 99  GLN 99  192 192 GLN GLN B . n 
B 1 100 HIS 100 193 193 HIS HIS B . n 
B 1 101 LEU 101 194 194 LEU LEU B . n 
B 1 102 ILE 102 195 195 ILE ILE B . n 
B 1 103 ARG 103 196 196 ARG ARG B . n 
B 1 104 VAL 104 197 197 VAL VAL B . n 
B 1 105 GLU 105 198 198 GLU GLU B . n 
B 1 106 GLY 106 199 199 GLY GLY B . n 
B 1 107 ASN 107 200 200 ASN ASN B . n 
B 1 108 LEU 108 201 201 LEU LEU B . n 
B 1 109 ARG 109 202 202 ARG ARG B . n 
B 1 110 ALA 110 203 203 ALA ALA B . n 
B 1 111 GLU 111 204 204 GLU GLU B . n 
B 1 112 TYR 112 205 205 TYR TYR B . n 
B 1 113 LEU 113 206 206 LEU LEU B . n 
B 1 114 ASP 114 207 207 ASP ASP B . n 
B 1 115 ASP 115 208 208 ASP ASP B . n 
B 1 116 ARG 116 209 209 ARG ARG B . n 
B 1 117 ASN 117 210 210 ASN ASN B . n 
B 1 118 THR 118 211 211 THR THR B . n 
B 1 119 PHE 119 212 212 PHE PHE B . n 
B 1 120 ARG 120 213 213 ARG ARG B . n 
B 1 121 HIS 121 214 214 HIS HIS B . n 
B 1 122 SER 122 215 215 SER SER B . n 
B 1 123 VAL 123 216 216 VAL VAL B . n 
B 1 124 VAL 124 217 217 VAL VAL B . n 
B 1 125 VAL 125 218 218 VAL VAL B . n 
B 1 126 PRO 126 219 219 PRO PRO B . n 
B 1 127 CYS 127 220 220 CYS CYS B . n 
B 1 128 GLU 128 221 221 GLU GLU B . n 
B 1 129 PRO 129 222 222 PRO PRO B . n 
B 1 130 PRO 130 223 223 PRO PRO B . n 
B 1 131 GLU 131 224 224 GLU GLU B . n 
B 1 132 VAL 132 225 225 VAL VAL B . n 
B 1 133 GLY 133 226 226 GLY GLY B . n 
B 1 134 SER 134 227 227 SER SER B . n 
B 1 135 ASP 135 228 228 ASP ASP B . n 
B 1 136 CYS 136 229 229 CYS CYS B . n 
B 1 137 THR 137 230 230 THR THR B . n 
B 1 138 THR 138 231 231 THR THR B . n 
B 1 139 ILE 139 232 232 ILE ILE B . n 
B 1 140 HIS 140 233 233 HIS HIS B . n 
B 1 141 TYR 141 234 234 TYR TYR B . n 
B 1 142 ASN 142 235 235 ASN ASN B . n 
B 1 143 TYR 143 236 236 TYR TYR B . n 
B 1 144 MET 144 237 237 MET MET B . n 
B 1 145 CYS 145 238 238 CYS CYS B . n 
B 1 146 TYR 146 239 239 TYR TYR B . n 
B 1 147 SER 147 240 240 SER SER B . n 
B 1 148 SER 148 241 241 SER SER B . n 
B 1 149 CYS 149 242 242 CYS CYS B . n 
B 1 150 MET 150 243 243 MET MET B . n 
B 1 151 GLY 151 244 244 GLY GLY B . n 
B 1 152 GLY 152 245 245 GLY GLY B . n 
B 1 153 MET 153 246 246 MET MET B . n 
B 1 154 ASN 154 247 247 ASN ASN B . n 
B 1 155 ARG 155 248 248 ARG ARG B . n 
B 1 156 ARG 156 249 249 ARG ARG B . n 
B 1 157 PRO 157 250 250 PRO PRO B . n 
B 1 158 ILE 158 251 251 ILE ILE B . n 
B 1 159 LEU 159 252 252 LEU LEU B . n 
B 1 160 THR 160 253 253 THR THR B . n 
B 1 161 ILE 161 254 254 ILE ILE B . n 
B 1 162 ILE 162 255 255 ILE ILE B . n 
B 1 163 THR 163 256 256 THR THR B . n 
B 1 164 LEU 164 257 257 LEU LEU B . n 
B 1 165 GLU 165 258 258 GLU GLU B . n 
B 1 166 ASP 166 259 259 ASP ASP B . n 
B 1 167 SER 167 260 260 SER SER B . n 
B 1 168 SER 168 261 261 SER SER B . n 
B 1 169 GLY 169 262 262 GLY GLY B . n 
B 1 170 ASN 170 263 263 ASN ASN B . n 
B 1 171 LEU 171 264 264 LEU LEU B . n 
B 1 172 LEU 172 265 265 LEU LEU B . n 
B 1 173 GLY 173 266 266 GLY GLY B . n 
B 1 174 ARG 174 267 267 ARG ARG B . n 
B 1 175 ASP 175 268 268 ASP ASP B . n 
B 1 176 SER 176 269 269 SER SER B . n 
B 1 177 PHE 177 270 270 PHE PHE B . n 
B 1 178 GLU 178 271 271 GLU GLU B . n 
B 1 179 VAL 179 272 272 VAL VAL B . n 
B 1 180 ARG 180 273 273 ARG ARG B . n 
B 1 181 VAL 181 274 274 VAL VAL B . n 
B 1 182 CYS 182 275 275 CYS CYS B . n 
B 1 183 ALA 183 276 276 ALA ALA B . n 
B 1 184 CYS 184 277 277 CYS CYS B . n 
B 1 185 PRO 185 278 278 PRO PRO B . n 
B 1 186 GLY 186 279 279 GLY GLY B . n 
B 1 187 ARG 187 280 280 ARG ARG B . n 
B 1 188 ASP 188 281 281 ASP ASP B . n 
B 1 189 ARG 189 282 282 ARG ARG B . n 
B 1 190 ARG 190 283 283 ARG ARG B . n 
B 1 191 THR 191 284 284 THR THR B . n 
B 1 192 GLU 192 285 285 GLU GLU B . n 
B 1 193 GLU 193 286 286 GLU GLU B . n 
B 1 194 GLU 194 287 287 GLU GLU B . n 
B 1 195 ASN 195 288 288 ASN ASN B . n 
B 1 196 LEU 196 289 289 LEU LEU B . n 
B 1 197 ARG 197 290 290 ARG ARG B . n 
B 1 198 LYS 198 291 291 LYS LYS B . n 
B 1 199 LYS 199 292 ?   ?   ?   B . n 
B 1 200 GLY 200 293 ?   ?   ?   B . n 
B 1 201 GLU 201 294 ?   ?   ?   B . n 
B 1 202 PRO 202 295 ?   ?   ?   B . n 
B 1 203 HIS 203 296 ?   ?   ?   B . n 
B 1 204 HIS 204 297 ?   ?   ?   B . n 
B 1 205 GLU 205 298 ?   ?   ?   B . n 
B 1 206 LEU 206 299 ?   ?   ?   B . n 
B 1 207 PRO 207 300 ?   ?   ?   B . n 
B 1 208 PRO 208 301 ?   ?   ?   B . n 
B 1 209 GLY 209 302 ?   ?   ?   B . n 
B 1 210 SER 210 303 ?   ?   ?   B . n 
B 1 211 THR 211 304 ?   ?   ?   B . n 
B 1 212 LYS 212 305 ?   ?   ?   B . n 
B 1 213 ARG 213 306 ?   ?   ?   B . n 
B 1 214 ALA 214 307 ?   ?   ?   B . n 
B 1 215 LEU 215 308 ?   ?   ?   B . n 
B 1 216 PRO 216 309 ?   ?   ?   B . n 
B 1 217 ASN 217 310 ?   ?   ?   B . n 
B 1 218 ASN 218 311 ?   ?   ?   B . n 
B 1 219 THR 219 312 ?   ?   ?   B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        YM0 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   YM0 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 YM0 1  401 301 YM0 UNL A . 
D 2 YM0 1  402 401 YM0 UNL A . 
E 3 EPE 1  403 602 EPE EPE A . 
F 4 PEG 1  404 603 PEG PEG A . 
G 5 ZN  1  405 1   ZN  ZN  A . 
H 3 EPE 1  401 301 EPE EPE B . 
I 2 YM0 1  402 302 YM0 UNL B . 
J 3 EPE 1  403 401 EPE EPE B . 
K 5 ZN  1  404 2   ZN  ZN  B . 
L 6 HOH 1  501 50  HOH HOH A . 
L 6 HOH 2  502 153 HOH HOH A . 
L 6 HOH 3  503 81  HOH HOH A . 
L 6 HOH 4  504 83  HOH HOH A . 
L 6 HOH 5  505 72  HOH HOH A . 
L 6 HOH 6  506 168 HOH HOH A . 
L 6 HOH 7  507 73  HOH HOH A . 
L 6 HOH 8  508 71  HOH HOH A . 
L 6 HOH 9  509 49  HOH HOH A . 
L 6 HOH 10 510 5   HOH HOH A . 
L 6 HOH 11 511 48  HOH HOH A . 
L 6 HOH 12 512 137 HOH HOH A . 
L 6 HOH 13 513 47  HOH HOH A . 
L 6 HOH 14 514 46  HOH HOH A . 
L 6 HOH 15 515 41  HOH HOH A . 
L 6 HOH 16 516 102 HOH HOH A . 
L 6 HOH 17 517 12  HOH HOH A . 
L 6 HOH 18 518 140 HOH HOH A . 
L 6 HOH 19 519 43  HOH HOH A . 
L 6 HOH 20 520 27  HOH HOH A . 
L 6 HOH 21 521 62  HOH HOH A . 
L 6 HOH 22 522 82  HOH HOH A . 
L 6 HOH 23 523 20  HOH HOH A . 
L 6 HOH 24 524 21  HOH HOH A . 
L 6 HOH 25 525 64  HOH HOH A . 
L 6 HOH 26 526 14  HOH HOH A . 
L 6 HOH 27 527 77  HOH HOH A . 
L 6 HOH 28 528 80  HOH HOH A . 
L 6 HOH 29 529 65  HOH HOH A . 
L 6 HOH 30 530 30  HOH HOH A . 
L 6 HOH 31 531 152 HOH HOH A . 
L 6 HOH 32 532 76  HOH HOH A . 
L 6 HOH 33 533 105 HOH HOH A . 
L 6 HOH 34 534 3   HOH HOH A . 
L 6 HOH 35 535 10  HOH HOH A . 
L 6 HOH 36 536 136 HOH HOH A . 
L 6 HOH 37 537 32  HOH HOH A . 
L 6 HOH 38 538 69  HOH HOH A . 
L 6 HOH 39 539 162 HOH HOH A . 
L 6 HOH 40 540 68  HOH HOH A . 
L 6 HOH 41 541 19  HOH HOH A . 
L 6 HOH 42 542 104 HOH HOH A . 
L 6 HOH 43 543 135 HOH HOH A . 
L 6 HOH 44 544 78  HOH HOH A . 
L 6 HOH 45 545 156 HOH HOH A . 
L 6 HOH 46 546 61  HOH HOH A . 
L 6 HOH 47 547 74  HOH HOH A . 
L 6 HOH 48 548 15  HOH HOH A . 
L 6 HOH 49 549 7   HOH HOH A . 
L 6 HOH 50 550 79  HOH HOH A . 
L 6 HOH 51 551 4   HOH HOH A . 
L 6 HOH 52 552 109 HOH HOH A . 
L 6 HOH 53 553 37  HOH HOH A . 
L 6 HOH 54 554 108 HOH HOH A . 
L 6 HOH 55 555 106 HOH HOH A . 
L 6 HOH 56 556 141 HOH HOH A . 
L 6 HOH 57 557 107 HOH HOH A . 
L 6 HOH 58 558 154 HOH HOH A . 
L 6 HOH 59 559 26  HOH HOH A . 
L 6 HOH 60 560 110 HOH HOH A . 
L 6 HOH 61 561 161 HOH HOH A . 
L 6 HOH 62 562 111 HOH HOH A . 
L 6 HOH 63 563 63  HOH HOH A . 
L 6 HOH 64 564 146 HOH HOH A . 
L 6 HOH 65 565 70  HOH HOH A . 
L 6 HOH 66 566 112 HOH HOH A . 
L 6 HOH 67 567 23  HOH HOH A . 
L 6 HOH 68 568 145 HOH HOH A . 
L 6 HOH 69 569 139 HOH HOH A . 
L 6 HOH 70 570 113 HOH HOH A . 
L 6 HOH 71 571 147 HOH HOH A . 
L 6 HOH 72 572 143 HOH HOH A . 
L 6 HOH 73 573 163 HOH HOH A . 
L 6 HOH 74 574 138 HOH HOH A . 
L 6 HOH 75 575 103 HOH HOH A . 
L 6 HOH 76 576 67  HOH HOH A . 
L 6 HOH 77 577 157 HOH HOH A . 
L 6 HOH 78 578 144 HOH HOH A . 
L 6 HOH 79 579 142 HOH HOH A . 
L 6 HOH 80 580 148 HOH HOH A . 
M 6 HOH 1  501 132 HOH HOH B . 
M 6 HOH 2  502 167 HOH HOH B . 
M 6 HOH 3  503 56  HOH HOH B . 
M 6 HOH 4  504 51  HOH HOH B . 
M 6 HOH 5  505 84  HOH HOH B . 
M 6 HOH 6  506 25  HOH HOH B . 
M 6 HOH 7  507 66  HOH HOH B . 
M 6 HOH 8  508 122 HOH HOH B . 
M 6 HOH 9  509 87  HOH HOH B . 
M 6 HOH 10 510 85  HOH HOH B . 
M 6 HOH 11 511 98  HOH HOH B . 
M 6 HOH 12 512 31  HOH HOH B . 
M 6 HOH 13 513 16  HOH HOH B . 
M 6 HOH 14 514 149 HOH HOH B . 
M 6 HOH 15 515 18  HOH HOH B . 
M 6 HOH 16 516 88  HOH HOH B . 
M 6 HOH 17 517 34  HOH HOH B . 
M 6 HOH 18 518 58  HOH HOH B . 
M 6 HOH 19 519 97  HOH HOH B . 
M 6 HOH 20 520 36  HOH HOH B . 
M 6 HOH 21 521 54  HOH HOH B . 
M 6 HOH 22 522 9   HOH HOH B . 
M 6 HOH 23 523 86  HOH HOH B . 
M 6 HOH 24 524 55  HOH HOH B . 
M 6 HOH 25 525 33  HOH HOH B . 
M 6 HOH 26 526 22  HOH HOH B . 
M 6 HOH 27 527 42  HOH HOH B . 
M 6 HOH 28 528 35  HOH HOH B . 
M 6 HOH 29 529 57  HOH HOH B . 
M 6 HOH 30 530 6   HOH HOH B . 
M 6 HOH 31 531 59  HOH HOH B . 
M 6 HOH 32 532 91  HOH HOH B . 
M 6 HOH 33 533 94  HOH HOH B . 
M 6 HOH 34 534 93  HOH HOH B . 
M 6 HOH 35 535 52  HOH HOH B . 
M 6 HOH 36 536 125 HOH HOH B . 
M 6 HOH 37 537 2   HOH HOH B . 
M 6 HOH 38 538 13  HOH HOH B . 
M 6 HOH 39 539 89  HOH HOH B . 
M 6 HOH 40 540 114 HOH HOH B . 
M 6 HOH 41 541 99  HOH HOH B . 
M 6 HOH 42 542 127 HOH HOH B . 
M 6 HOH 43 543 134 HOH HOH B . 
M 6 HOH 44 544 126 HOH HOH B . 
M 6 HOH 45 545 116 HOH HOH B . 
M 6 HOH 46 546 8   HOH HOH B . 
M 6 HOH 47 547 90  HOH HOH B . 
M 6 HOH 48 548 130 HOH HOH B . 
M 6 HOH 49 549 100 HOH HOH B . 
M 6 HOH 50 550 121 HOH HOH B . 
M 6 HOH 51 551 24  HOH HOH B . 
M 6 HOH 52 552 96  HOH HOH B . 
M 6 HOH 53 553 40  HOH HOH B . 
M 6 HOH 54 554 44  HOH HOH B . 
M 6 HOH 55 555 169 HOH HOH B . 
M 6 HOH 56 556 129 HOH HOH B . 
M 6 HOH 57 557 133 HOH HOH B . 
M 6 HOH 58 558 166 HOH HOH B . 
M 6 HOH 59 559 150 HOH HOH B . 
M 6 HOH 60 560 28  HOH HOH B . 
M 6 HOH 61 561 123 HOH HOH B . 
M 6 HOH 62 562 170 HOH HOH B . 
M 6 HOH 63 563 128 HOH HOH B . 
M 6 HOH 64 564 120 HOH HOH B . 
M 6 HOH 65 565 124 HOH HOH B . 
M 6 HOH 66 566 11  HOH HOH B . 
M 6 HOH 67 567 151 HOH HOH B . 
M 6 HOH 68 568 119 HOH HOH B . 
M 6 HOH 69 569 115 HOH HOH B . 
M 6 HOH 70 570 95  HOH HOH B . 
M 6 HOH 71 571 92  HOH HOH B . 
M 6 HOH 72 572 160 HOH HOH B . 
M 6 HOH 73 573 171 HOH HOH B . 
M 6 HOH 74 574 164 HOH HOH B . 
M 6 HOH 75 575 45  HOH HOH B . 
M 6 HOH 76 576 165 HOH HOH B . 
M 6 HOH 77 577 131 HOH HOH B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1   1 Y 1 A LYS 101 ? CD  ? A LYS 8   CD  
2   1 Y 1 A LYS 101 ? CE  ? A LYS 8   CE  
3   1 Y 1 A LYS 101 ? NZ  ? A LYS 8   NZ  
4   1 Y 1 A ARG 110 ? CZ  ? A ARG 17  CZ  
5   1 Y 1 A ARG 110 ? NH1 ? A ARG 17  NH1 
6   1 Y 1 A ARG 110 ? NH2 ? A ARG 17  NH2 
7   1 Y 1 A SER 116 ? OG  ? A SER 23  OG  
8   1 Y 1 A LYS 120 ? CG  ? A LYS 27  CG  
9   1 Y 1 A LYS 120 ? CD  ? A LYS 27  CD  
10  1 Y 1 A LYS 120 ? CE  ? A LYS 27  CE  
11  1 Y 1 A LYS 120 ? NZ  ? A LYS 27  NZ  
12  1 Y 1 A LYS 139 ? NZ  ? A LYS 46  NZ  
13  1 Y 1 A TRP 146 ? CG  ? A TRP 53  CG  
14  1 Y 1 A TRP 146 ? CD1 ? A TRP 53  CD1 
15  1 Y 1 A TRP 146 ? CD2 ? A TRP 53  CD2 
16  1 Y 1 A TRP 146 ? NE1 ? A TRP 53  NE1 
17  1 Y 1 A TRP 146 ? CE2 ? A TRP 53  CE2 
18  1 Y 1 A TRP 146 ? CE3 ? A TRP 53  CE3 
19  1 Y 1 A TRP 146 ? CZ2 ? A TRP 53  CZ2 
20  1 Y 1 A TRP 146 ? CZ3 ? A TRP 53  CZ3 
21  1 Y 1 A TRP 146 ? CH2 ? A TRP 53  CH2 
22  1 Y 1 A SER 183 ? OG  ? A SER 90  OG  
23  1 Y 1 A ARG 202 ? NE  ? A ARG 109 NE  
24  1 Y 1 A ARG 202 ? CZ  ? A ARG 109 CZ  
25  1 Y 1 A ARG 202 ? NH1 ? A ARG 109 NH1 
26  1 Y 1 A ARG 202 ? NH2 ? A ARG 109 NH2 
27  1 Y 1 A ARG 209 ? CD  ? A ARG 116 CD  
28  1 Y 1 A ARG 209 ? NE  ? A ARG 116 NE  
29  1 Y 1 A ARG 209 ? CZ  ? A ARG 116 CZ  
30  1 Y 1 A ARG 209 ? NH1 ? A ARG 116 NH1 
31  1 Y 1 A ARG 209 ? NH2 ? A ARG 116 NH2 
32  1 Y 1 A GLU 221 ? CD  ? A GLU 128 CD  
33  1 Y 1 A GLU 221 ? OE1 ? A GLU 128 OE1 
34  1 Y 1 A GLU 221 ? OE2 ? A GLU 128 OE2 
35  1 Y 1 A GLU 224 ? CD  ? A GLU 131 CD  
36  1 Y 1 A GLU 224 ? OE1 ? A GLU 131 OE1 
37  1 Y 1 A GLU 224 ? OE2 ? A GLU 131 OE2 
38  1 Y 1 A VAL 225 ? CG1 ? A VAL 132 CG1 
39  1 Y 1 A VAL 225 ? CG2 ? A VAL 132 CG2 
40  1 Y 1 A ASP 228 ? CG  ? A ASP 135 CG  
41  1 Y 1 A ASP 228 ? OD1 ? A ASP 135 OD1 
42  1 Y 1 A ASP 228 ? OD2 ? A ASP 135 OD2 
43  1 Y 1 A ARG 280 ? CG  ? A ARG 187 CG  
44  1 Y 1 A ARG 280 ? CD  ? A ARG 187 CD  
45  1 Y 1 A ARG 280 ? NE  ? A ARG 187 NE  
46  1 Y 1 A ARG 280 ? CZ  ? A ARG 187 CZ  
47  1 Y 1 A ARG 280 ? NH1 ? A ARG 187 NH1 
48  1 Y 1 A ARG 280 ? NH2 ? A ARG 187 NH2 
49  1 Y 1 A ARG 283 ? CG  ? A ARG 190 CG  
50  1 Y 1 A ARG 283 ? CD  ? A ARG 190 CD  
51  1 Y 1 A ARG 283 ? NE  ? A ARG 190 NE  
52  1 Y 1 A ARG 283 ? CZ  ? A ARG 190 CZ  
53  1 Y 1 A ARG 283 ? NH1 ? A ARG 190 NH1 
54  1 Y 1 A ARG 283 ? NH2 ? A ARG 190 NH2 
55  1 Y 1 A GLU 287 ? CG  ? A GLU 194 CG  
56  1 Y 1 A GLU 287 ? CD  ? A GLU 194 CD  
57  1 Y 1 A GLU 287 ? OE1 ? A GLU 194 OE1 
58  1 Y 1 A GLU 287 ? OE2 ? A GLU 194 OE2 
59  1 Y 1 A ARG 290 ? CG  ? A ARG 197 CG  
60  1 Y 1 A ARG 290 ? CD  ? A ARG 197 CD  
61  1 Y 1 A ARG 290 ? NE  ? A ARG 197 NE  
62  1 Y 1 A ARG 290 ? CZ  ? A ARG 197 CZ  
63  1 Y 1 A ARG 290 ? NH1 ? A ARG 197 NH1 
64  1 Y 1 A ARG 290 ? NH2 ? A ARG 197 NH2 
65  1 Y 1 A LYS 291 ? CG  ? A LYS 198 CG  
66  1 Y 1 A LYS 291 ? CD  ? A LYS 198 CD  
67  1 Y 1 A LYS 291 ? CE  ? A LYS 198 CE  
68  1 Y 1 A LYS 291 ? NZ  ? A LYS 198 NZ  
69  1 Y 1 B SER 95  ? OG  ? B SER 2   OG  
70  1 Y 1 B LYS 101 ? NZ  ? B LYS 8   NZ  
71  1 Y 1 B ARG 110 ? CZ  ? B ARG 17  CZ  
72  1 Y 1 B ARG 110 ? NH1 ? B ARG 17  NH1 
73  1 Y 1 B ARG 110 ? NH2 ? B ARG 17  NH2 
74  1 Y 1 B LYS 120 ? CG  ? B LYS 27  CG  
75  1 Y 1 B LYS 120 ? CD  ? B LYS 27  CD  
76  1 Y 1 B LYS 120 ? CE  ? B LYS 27  CE  
77  1 Y 1 B LYS 120 ? NZ  ? B LYS 27  NZ  
78  1 Y 1 B SER 121 ? OG  ? B SER 28  OG  
79  1 Y 1 B LYS 139 ? NZ  ? B LYS 46  NZ  
80  1 Y 1 B TRP 146 ? CG  ? B TRP 53  CG  
81  1 Y 1 B TRP 146 ? CD1 ? B TRP 53  CD1 
82  1 Y 1 B TRP 146 ? CD2 ? B TRP 53  CD2 
83  1 Y 1 B TRP 146 ? NE1 ? B TRP 53  NE1 
84  1 Y 1 B TRP 146 ? CE2 ? B TRP 53  CE2 
85  1 Y 1 B TRP 146 ? CE3 ? B TRP 53  CE3 
86  1 Y 1 B TRP 146 ? CZ2 ? B TRP 53  CZ2 
87  1 Y 1 B TRP 146 ? CZ3 ? B TRP 53  CZ3 
88  1 Y 1 B TRP 146 ? CH2 ? B TRP 53  CH2 
89  1 Y 1 B SER 183 ? OG  ? B SER 90  OG  
90  1 Y 1 B ARG 202 ? NE  ? B ARG 109 NE  
91  1 Y 1 B ARG 202 ? CZ  ? B ARG 109 CZ  
92  1 Y 1 B ARG 202 ? NH1 ? B ARG 109 NH1 
93  1 Y 1 B ARG 202 ? NH2 ? B ARG 109 NH2 
94  1 Y 1 B ARG 209 ? CD  ? B ARG 116 CD  
95  1 Y 1 B ARG 209 ? NE  ? B ARG 116 NE  
96  1 Y 1 B ARG 209 ? CZ  ? B ARG 116 CZ  
97  1 Y 1 B ARG 209 ? NH1 ? B ARG 116 NH1 
98  1 Y 1 B ARG 209 ? NH2 ? B ARG 116 NH2 
99  1 Y 1 B GLU 221 ? CD  ? B GLU 128 CD  
100 1 Y 1 B GLU 221 ? OE1 ? B GLU 128 OE1 
101 1 Y 1 B GLU 221 ? OE2 ? B GLU 128 OE2 
102 1 Y 1 B GLU 224 ? CG  ? B GLU 131 CG  
103 1 Y 1 B GLU 224 ? CD  ? B GLU 131 CD  
104 1 Y 1 B GLU 224 ? OE1 ? B GLU 131 OE1 
105 1 Y 1 B GLU 224 ? OE2 ? B GLU 131 OE2 
106 1 Y 1 B VAL 225 ? CG1 ? B VAL 132 CG1 
107 1 Y 1 B VAL 225 ? CG2 ? B VAL 132 CG2 
108 1 Y 1 B ASP 228 ? CG  ? B ASP 135 CG  
109 1 Y 1 B ASP 228 ? OD1 ? B ASP 135 OD1 
110 1 Y 1 B ASP 228 ? OD2 ? B ASP 135 OD2 
111 1 Y 1 B ARG 248 ? NE  ? B ARG 155 NE  
112 1 Y 1 B ARG 248 ? CZ  ? B ARG 155 CZ  
113 1 Y 1 B ARG 248 ? NH1 ? B ARG 155 NH1 
114 1 Y 1 B ARG 248 ? NH2 ? B ARG 155 NH2 
115 1 Y 1 B ARG 280 ? CD  ? B ARG 187 CD  
116 1 Y 1 B ARG 280 ? NE  ? B ARG 187 NE  
117 1 Y 1 B ARG 280 ? CZ  ? B ARG 187 CZ  
118 1 Y 1 B ARG 280 ? NH1 ? B ARG 187 NH1 
119 1 Y 1 B ARG 280 ? NH2 ? B ARG 187 NH2 
120 1 Y 1 B ARG 283 ? CG  ? B ARG 190 CG  
121 1 Y 1 B ARG 283 ? CD  ? B ARG 190 CD  
122 1 Y 1 B ARG 283 ? NE  ? B ARG 190 NE  
123 1 Y 1 B ARG 283 ? CZ  ? B ARG 190 CZ  
124 1 Y 1 B ARG 283 ? NH1 ? B ARG 190 NH1 
125 1 Y 1 B ARG 283 ? NH2 ? B ARG 190 NH2 
126 1 Y 1 B GLU 287 ? CG  ? B GLU 194 CG  
127 1 Y 1 B GLU 287 ? CD  ? B GLU 194 CD  
128 1 Y 1 B GLU 287 ? OE1 ? B GLU 194 OE1 
129 1 Y 1 B GLU 287 ? OE2 ? B GLU 194 OE2 
130 1 Y 1 B ARG 290 ? CG  ? B ARG 197 CG  
131 1 Y 1 B ARG 290 ? CD  ? B ARG 197 CD  
132 1 Y 1 B ARG 290 ? NE  ? B ARG 197 NE  
133 1 Y 1 B ARG 290 ? CZ  ? B ARG 197 CZ  
134 1 Y 1 B ARG 290 ? NH1 ? B ARG 197 NH1 
135 1 Y 1 B ARG 290 ? NH2 ? B ARG 197 NH2 
136 1 Y 1 B LYS 291 ? CG  ? B LYS 198 CG  
137 1 Y 1 B LYS 291 ? CD  ? B LYS 198 CD  
138 1 Y 1 B LYS 291 ? CE  ? B LYS 198 CE  
139 1 Y 1 B LYS 291 ? NZ  ? B LYS 198 NZ  
140 1 N 1 A EPE 403 ? C7  ? E EPE 1   C7  
141 1 N 1 A EPE 403 ? C8  ? E EPE 1   C8  
142 1 N 1 A EPE 403 ? O8  ? E EPE 1   O8  
143 1 N 1 A PEG 404 ? O1  ? F PEG 1   O1  
144 1 N 1 B EPE 401 ? C7  ? H EPE 1   C7  
145 1 N 1 B EPE 401 ? C8  ? H EPE 1   C8  
146 1 N 1 B EPE 401 ? O8  ? H EPE 1   O8  
147 1 N 1 B EPE 403 ? N1  ? J EPE 1   N1  
148 1 N 1 B EPE 403 ? C2  ? J EPE 1   C2  
149 1 N 1 B EPE 403 ? C3  ? J EPE 1   C3  
150 1 N 1 B EPE 403 ? N4  ? J EPE 1   N4  
151 1 N 1 B EPE 403 ? C5  ? J EPE 1   C5  
152 1 N 1 B EPE 403 ? C6  ? J EPE 1   C6  
153 1 N 1 B EPE 403 ? C7  ? J EPE 1   C7  
154 1 N 1 B EPE 403 ? C8  ? J EPE 1   C8  
155 1 N 1 B EPE 403 ? O8  ? J EPE 1   O8  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.20.1_4487 1 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.20.1_4487 2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           3 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           4 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .           5 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8RBC 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     65.909 
_cell.length_a_esd                 ? 
_cell.length_b                     71.088 
_cell.length_b_esd                 ? 
_cell.length_c                     107.057 
_cell.length_c_esd                 ? 
_cell.volume                       501598.336 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8RBC 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            'P 2ac 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8RBC 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.83 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          56.50 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.2 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '100 mM HEPES (pH = 7.2), 19 % PEG4000 and 10 mM DTT' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-03-30 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SLS BEAMLINE X06SA' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   X06SA 
_diffrn_source.pdbx_synchrotron_site       SLS 
# 
_reflns.B_iso_Wilson_estimate                          48.16 
_reflns.entry_id                                       8RBC 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.06 
_reflns.d_resolution_low                               50 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     31776 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                13.37 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          10.48 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.06 
_reflns_shell.d_res_low                                     2.18 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           1.01 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             5024 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               13.5 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.737 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          100 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               49.00 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8RBC 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.06 
_refine.ls_d_res_low                             48.33 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     31581 
_refine.ls_number_reflns_R_free                  1497 
_refine.ls_number_reflns_R_work                  30084 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.37 
_refine.ls_percent_reflns_R_free                 4.74 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2231 
_refine.ls_R_factor_R_free                       0.2602 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2214 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.35 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 33.9580 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.3133 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.06 
_refine_hist.d_res_low                        48.33 
_refine_hist.number_atoms_solvent             157 
_refine_hist.number_atoms_total               3179 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2951 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         71 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0072 ? 3133 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.8983 ? 4266 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0540 ? 471  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0085 ? 559  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 9.9803 ? 484  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.06 2.13  . . 133 2678 99.26 . . . . 0.4219 . . . . . . . . . . . 0.4377 
'X-RAY DIFFRACTION' 2.13 2.20  . . 135 2679 98.91 . . . . 0.3733 . . . . . . . . . . . 0.3669 
'X-RAY DIFFRACTION' 2.20 2.29  . . 135 2688 98.88 . . . . 0.3255 . . . . . . . . . . . 0.3488 
'X-RAY DIFFRACTION' 2.29 2.40  . . 132 2677 99.40 . . . . 0.2970 . . . . . . . . . . . 0.3283 
'X-RAY DIFFRACTION' 2.40 2.52  . . 135 2713 99.44 . . . . 0.2759 . . . . . . . . . . . 0.3052 
'X-RAY DIFFRACTION' 2.52 2.68  . . 135 2729 99.41 . . . . 0.2531 . . . . . . . . . . . 0.2692 
'X-RAY DIFFRACTION' 2.68 2.89  . . 136 2705 99.16 . . . . 0.2335 . . . . . . . . . . . 0.3218 
'X-RAY DIFFRACTION' 2.89 3.18  . . 135 2736 99.55 . . . . 0.2197 . . . . . . . . . . . 0.2965 
'X-RAY DIFFRACTION' 3.18 3.64  . . 136 2752 99.41 . . . . 0.2017 . . . . . . . . . . . 0.2422 
'X-RAY DIFFRACTION' 3.64 4.58  . . 138 2799 99.69 . . . . 0.1770 . . . . . . . . . . . 0.2171 
'X-RAY DIFFRACTION' 4.58 48.33 . . 147 2928 99.94 . . . . 0.1856 . . . . . . . . . . . 0.2122 
# 
_struct.entry_id                     8RBC 
_struct.title                        
'p53-Y220C Core Domain Covalently Bound to 3-amino-5-chloropyrazine-2,6-dicarbonitrile Soaked at 5 mM' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8RBC 
_struct_keywords.text            'Covalent, SNAr, Stabilization, CELL CYCLE' 
_struct_keywords.pdbx_keywords   'CELL CYCLE' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 2 ? 
E N N 3 ? 
F N N 4 ? 
G N N 5 ? 
H N N 3 ? 
I N N 2 ? 
J N N 3 ? 
K N N 5 ? 
L N N 6 ? 
M N N 6 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    P53_HUMAN 
_struct_ref.pdbx_db_accession          P04637 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVV
RRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILT
IITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNT
;
_struct_ref.pdbx_align_begin           94 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8RBC A 1 ? 219 ? P04637 94 ? 312 ? 94 312 
2 1 8RBC B 1 ? 219 ? P04637 94 ? 312 ? 94 312 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8RBC LEU A 40  ? UNP P04637 MET 133 'engineered mutation' 133 1  
1 8RBC ALA A 110 ? UNP P04637 VAL 203 'engineered mutation' 203 2  
1 8RBC CYS A 127 ? UNP P04637 TYR 220 'engineered mutation' 220 3  
1 8RBC TYR A 146 ? UNP P04637 ASN 239 'engineered mutation' 239 4  
1 8RBC ASP A 175 ? UNP P04637 ASN 268 'engineered mutation' 268 5  
2 8RBC LEU B 40  ? UNP P04637 MET 133 'engineered mutation' 133 6  
2 8RBC ALA B 110 ? UNP P04637 VAL 203 'engineered mutation' 203 7  
2 8RBC CYS B 127 ? UNP P04637 TYR 220 'engineered mutation' 220 8  
2 8RBC TYR B 146 ? UNP P04637 ASN 239 'engineered mutation' 239 9  
2 8RBC ASP B 175 ? UNP P04637 ASN 268 'engineered mutation' 268 10 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_defined_assembly ? monomeric 1 
2 author_defined_assembly ? monomeric 1 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,C,D,E,F,G,L 
2 1 B,H,I,J,K,M   
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 HIS A 85  ? CYS A 89  ? HIS A 178 CYS A 182 5 ? 5  
HELX_P HELX_P2 AA2 CYS A 184 ? LYS A 198 ? CYS A 277 LYS A 291 1 ? 15 
HELX_P HELX_P3 AA3 GLN B 11  ? GLY B 15  ? GLN B 104 GLY B 108 5 ? 5  
HELX_P HELX_P4 AA4 GLN B 72  ? MET B 76  ? GLN B 165 MET B 169 5 ? 5  
HELX_P HELX_P5 AA5 HIS B 85  ? CYS B 89  ? HIS B 178 CYS B 182 5 ? 5  
HELX_P HELX_P6 AA6 CYS B 184 ? LYS B 198 ? CYS B 277 LYS B 291 1 ? 15 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
covale1 covale none ? A CYS 89  SG  ? ? ? 1_555 D YM0 . C4 ? ? A CYS 182 A YM0 402 1_555 ? ? ? ? ? ? ? 1.762 ? ? 
covale2 covale none ? A CYS 127 SG  ? ? ? 1_555 C YM0 . C4 ? ? A CYS 220 A YM0 401 1_555 ? ? ? ? ? ? ? 1.765 ? ? 
covale3 covale none ? B CYS 127 SG  ? ? ? 1_555 I YM0 . C4 ? ? B CYS 220 B YM0 402 1_555 ? ? ? ? ? ? ? 1.766 ? ? 
metalc1 metalc ?    ? A CYS 83  SG  ? ? ? 1_555 G ZN  . ZN ? ? A CYS 176 A ZN  405 1_555 ? ? ? ? ? ? ? 2.301 ? ? 
metalc2 metalc ?    ? A HIS 86  ND1 ? ? ? 1_555 G ZN  . ZN ? ? A HIS 179 A ZN  405 1_555 ? ? ? ? ? ? ? 1.849 ? ? 
metalc3 metalc ?    ? A CYS 145 SG  ? ? ? 1_555 G ZN  . ZN ? ? A CYS 238 A ZN  405 1_555 ? ? ? ? ? ? ? 2.298 ? ? 
metalc4 metalc ?    ? A CYS 149 SG  ? ? ? 1_555 G ZN  . ZN ? ? A CYS 242 A ZN  405 1_555 ? ? ? ? ? ? ? 2.312 ? ? 
metalc5 metalc ?    ? B CYS 83  SG  ? ? ? 1_555 K ZN  . ZN ? ? B CYS 176 B ZN  404 1_555 ? ? ? ? ? ? ? 2.293 ? ? 
metalc6 metalc ?    ? B HIS 86  ND1 ? ? ? 1_555 K ZN  . ZN ? ? B HIS 179 B ZN  404 1_555 ? ? ? ? ? ? ? 1.967 ? ? 
metalc7 metalc ?    ? B CYS 145 SG  ? ? ? 1_555 K ZN  . ZN ? ? B CYS 238 B ZN  404 1_555 ? ? ? ? ? ? ? 2.299 ? ? 
metalc8 metalc ?    ? B CYS 149 SG  ? ? ? 1_555 K ZN  . ZN ? ? B CYS 242 B ZN  404 1_555 ? ? ? ? ? ? ? 2.295 ? ? 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
covale ? ? 
metalc ? ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  SG  ? A CYS 83  ? A CYS 176 ? 1_555 ZN ? G ZN . ? A ZN 405 ? 1_555 ND1 ? A HIS 86  ? A HIS 179 ? 1_555 102.2 ? 
2  SG  ? A CYS 83  ? A CYS 176 ? 1_555 ZN ? G ZN . ? A ZN 405 ? 1_555 SG  ? A CYS 145 ? A CYS 238 ? 1_555 109.0 ? 
3  ND1 ? A HIS 86  ? A HIS 179 ? 1_555 ZN ? G ZN . ? A ZN 405 ? 1_555 SG  ? A CYS 145 ? A CYS 238 ? 1_555 108.3 ? 
4  SG  ? A CYS 83  ? A CYS 176 ? 1_555 ZN ? G ZN . ? A ZN 405 ? 1_555 SG  ? A CYS 149 ? A CYS 242 ? 1_555 112.5 ? 
5  ND1 ? A HIS 86  ? A HIS 179 ? 1_555 ZN ? G ZN . ? A ZN 405 ? 1_555 SG  ? A CYS 149 ? A CYS 242 ? 1_555 106.2 ? 
6  SG  ? A CYS 145 ? A CYS 238 ? 1_555 ZN ? G ZN . ? A ZN 405 ? 1_555 SG  ? A CYS 149 ? A CYS 242 ? 1_555 117.4 ? 
7  SG  ? B CYS 83  ? B CYS 176 ? 1_555 ZN ? K ZN . ? B ZN 404 ? 1_555 ND1 ? B HIS 86  ? B HIS 179 ? 1_555 105.6 ? 
8  SG  ? B CYS 83  ? B CYS 176 ? 1_555 ZN ? K ZN . ? B ZN 404 ? 1_555 SG  ? B CYS 145 ? B CYS 238 ? 1_555 107.3 ? 
9  ND1 ? B HIS 86  ? B HIS 179 ? 1_555 ZN ? K ZN . ? B ZN 404 ? 1_555 SG  ? B CYS 145 ? B CYS 238 ? 1_555 106.6 ? 
10 SG  ? B CYS 83  ? B CYS 176 ? 1_555 ZN ? K ZN . ? B ZN 404 ? 1_555 SG  ? B CYS 149 ? B CYS 242 ? 1_555 113.8 ? 
11 ND1 ? B HIS 86  ? B HIS 179 ? 1_555 ZN ? K ZN . ? B ZN 404 ? 1_555 SG  ? B CYS 149 ? B CYS 242 ? 1_555 105.5 ? 
12 SG  ? B CYS 145 ? B CYS 238 ? 1_555 ZN ? K ZN . ? B ZN 404 ? 1_555 SG  ? B CYS 149 ? B CYS 242 ? 1_555 117.1 ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 YM0 C . ? CYS A 127 ? YM0 A 401 ? 1_555 CYS A 220 ? 1_555 C4 SG CYS 1 YM0 None 'Covalent chemical modification' 
2 YM0 D . ? CYS A 89  ? YM0 A 402 ? 1_555 CYS A 182 ? 1_555 C4 SG CYS 1 YM0 None 'Covalent chemical modification' 
3 YM0 I . ? CYS B 127 ? YM0 B 402 ? 1_555 CYS B 220 ? 1_555 C4 SG CYS 1 YM0 None 'Covalent chemical modification' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 7 ? 
AA3 ? 4 ? 
AA4 ? 7 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? parallel      
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA2 5 6 ? anti-parallel 
AA2 6 7 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? parallel      
AA4 3 4 ? anti-parallel 
AA4 4 5 ? anti-parallel 
AA4 5 6 ? anti-parallel 
AA4 6 7 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ARG A 17  ? GLY A 19  ? ARG A 110 GLY A 112 
AA1 2 CYS A 48  ? TRP A 53  ? CYS A 141 TRP A 146 
AA1 3 THR A 137 ? TYR A 143 ? THR A 230 TYR A 236 
AA1 4 ILE A 102 ? VAL A 104 ? ILE A 195 VAL A 197 
AA2 1 CYS A 31  ? SER A 34  ? CYS A 124 SER A 127 
AA2 2 LYS A 39  ? CYS A 42  ? LYS A 132 CYS A 135 
AA2 3 LEU A 171 ? VAL A 181 ? LEU A 264 VAL A 274 
AA2 4 ILE A 158 ? GLU A 165 ? ILE A 251 GLU A 258 
AA2 5 ARG A 63  ? TYR A 70  ? ARG A 156 TYR A 163 
AA2 6 HIS A 121 ? PRO A 126 ? HIS A 214 PRO A 219 
AA2 7 GLU A 111 ? ASP A 114 ? GLU A 204 ASP A 207 
AA3 1 ARG B 17  ? GLY B 19  ? ARG B 110 GLY B 112 
AA3 2 CYS B 48  ? TRP B 53  ? CYS B 141 TRP B 146 
AA3 3 THR B 137 ? TYR B 143 ? THR B 230 TYR B 236 
AA3 4 ILE B 102 ? GLU B 105 ? ILE B 195 GLU B 198 
AA4 1 CYS B 31  ? SER B 34  ? CYS B 124 SER B 127 
AA4 2 LYS B 39  ? CYS B 42  ? LYS B 132 CYS B 135 
AA4 3 LEU B 171 ? VAL B 181 ? LEU B 264 VAL B 274 
AA4 4 ILE B 158 ? GLU B 165 ? ILE B 251 GLU B 258 
AA4 5 ARG B 63  ? TYR B 70  ? ARG B 156 TYR B 163 
AA4 6 HIS B 121 ? PRO B 126 ? HIS B 214 PRO B 219 
AA4 7 GLU B 111 ? ASP B 114 ? GLU B 204 ASP B 207 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N GLY A 19  ? N GLY A 112 O GLN A 51  ? O GLN A 144 
AA1 2 3 N LEU A 52  ? N LEU A 145 O THR A 137 ? O THR A 230 
AA1 3 4 O ASN A 142 ? O ASN A 235 N ARG A 103 ? N ARG A 196 
AA2 1 2 N THR A 32  ? N THR A 125 O PHE A 41  ? O PHE A 134 
AA2 2 3 N LEU A 40  ? N LEU A 133 O GLU A 178 ? O GLU A 271 
AA2 3 4 O PHE A 177 ? O PHE A 270 N THR A 160 ? N THR A 253 
AA2 4 5 O ILE A 161 ? O ILE A 254 N MET A 67  ? N MET A 160 
AA2 5 6 N VAL A 64  ? N VAL A 157 O VAL A 125 ? O VAL A 218 
AA2 6 7 O VAL A 124 ? O VAL A 217 N GLU A 111 ? N GLU A 204 
AA3 1 2 N GLY B 19  ? N GLY B 112 O GLN B 51  ? O GLN B 144 
AA3 2 3 N LEU B 52  ? N LEU B 145 O THR B 137 ? O THR B 230 
AA3 3 4 O HIS B 140 ? O HIS B 233 N GLU B 105 ? N GLU B 198 
AA4 1 2 N THR B 32  ? N THR B 125 O PHE B 41  ? O PHE B 134 
AA4 2 3 N LEU B 40  ? N LEU B 133 O ARG B 180 ? O ARG B 273 
AA4 3 4 O LEU B 172 ? O LEU B 265 N LEU B 164 ? N LEU B 257 
AA4 4 5 O ILE B 161 ? O ILE B 254 N MET B 67  ? N MET B 160 
AA4 5 6 N VAL B 64  ? N VAL B 157 O VAL B 125 ? O VAL B 218 
AA4 6 7 O VAL B 124 ? O VAL B 217 N GLU B 111 ? N GLU B 204 
# 
_pdbx_entry_details.entry_id                   8RBC 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 186 ? ? -67.12  4.01  
2 1 ASP B 184 ? ? -142.67 25.71 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x,y+1/2,-z+1/2 
4 -x+1/2,-y,z+1/2 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A SER 94  ? A SER 1   
2  1 Y 1 A LYS 292 ? A LYS 199 
3  1 Y 1 A GLY 293 ? A GLY 200 
4  1 Y 1 A GLU 294 ? A GLU 201 
5  1 Y 1 A PRO 295 ? A PRO 202 
6  1 Y 1 A HIS 296 ? A HIS 203 
7  1 Y 1 A HIS 297 ? A HIS 204 
8  1 Y 1 A GLU 298 ? A GLU 205 
9  1 Y 1 A LEU 299 ? A LEU 206 
10 1 Y 1 A PRO 300 ? A PRO 207 
11 1 Y 1 A PRO 301 ? A PRO 208 
12 1 Y 1 A GLY 302 ? A GLY 209 
13 1 Y 1 A SER 303 ? A SER 210 
14 1 Y 1 A THR 304 ? A THR 211 
15 1 Y 1 A LYS 305 ? A LYS 212 
16 1 Y 1 A ARG 306 ? A ARG 213 
17 1 Y 1 A ALA 307 ? A ALA 214 
18 1 Y 1 A LEU 308 ? A LEU 215 
19 1 Y 1 A PRO 309 ? A PRO 216 
20 1 Y 1 A ASN 310 ? A ASN 217 
21 1 Y 1 A ASN 311 ? A ASN 218 
22 1 Y 1 A THR 312 ? A THR 219 
23 1 Y 1 B SER 94  ? B SER 1   
24 1 Y 1 B LYS 292 ? B LYS 199 
25 1 Y 1 B GLY 293 ? B GLY 200 
26 1 Y 1 B GLU 294 ? B GLU 201 
27 1 Y 1 B PRO 295 ? B PRO 202 
28 1 Y 1 B HIS 296 ? B HIS 203 
29 1 Y 1 B HIS 297 ? B HIS 204 
30 1 Y 1 B GLU 298 ? B GLU 205 
31 1 Y 1 B LEU 299 ? B LEU 206 
32 1 Y 1 B PRO 300 ? B PRO 207 
33 1 Y 1 B PRO 301 ? B PRO 208 
34 1 Y 1 B GLY 302 ? B GLY 209 
35 1 Y 1 B SER 303 ? B SER 210 
36 1 Y 1 B THR 304 ? B THR 211 
37 1 Y 1 B LYS 305 ? B LYS 212 
38 1 Y 1 B ARG 306 ? B ARG 213 
39 1 Y 1 B ALA 307 ? B ALA 214 
40 1 Y 1 B LEU 308 ? B LEU 215 
41 1 Y 1 B PRO 309 ? B PRO 216 
42 1 Y 1 B ASN 310 ? B ASN 217 
43 1 Y 1 B ASN 311 ? B ASN 218 
44 1 Y 1 B THR 312 ? B THR 219 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CYS N    N  N N 74  
CYS CA   C  N R 75  
CYS C    C  N N 76  
CYS O    O  N N 77  
CYS CB   C  N N 78  
CYS SG   S  N N 79  
CYS OXT  O  N N 80  
CYS H    H  N N 81  
CYS H2   H  N N 82  
CYS HA   H  N N 83  
CYS HB2  H  N N 84  
CYS HB3  H  N N 85  
CYS HG   H  N N 86  
CYS HXT  H  N N 87  
EPE N1   N  N N 88  
EPE C2   C  N N 89  
EPE C3   C  N N 90  
EPE N4   N  N N 91  
EPE C5   C  N N 92  
EPE C6   C  N N 93  
EPE C7   C  N N 94  
EPE C8   C  N N 95  
EPE O8   O  N N 96  
EPE C9   C  N N 97  
EPE C10  C  N N 98  
EPE S    S  N N 99  
EPE O1S  O  N N 100 
EPE O2S  O  N N 101 
EPE O3S  O  N N 102 
EPE H21  H  N N 103 
EPE H22  H  N N 104 
EPE H31  H  N N 105 
EPE H32  H  N N 106 
EPE H51  H  N N 107 
EPE H52  H  N N 108 
EPE H61  H  N N 109 
EPE H62  H  N N 110 
EPE H71  H  N N 111 
EPE H72  H  N N 112 
EPE H81  H  N N 113 
EPE H82  H  N N 114 
EPE HO8  H  N N 115 
EPE H91  H  N N 116 
EPE H92  H  N N 117 
EPE H101 H  N N 118 
EPE H102 H  N N 119 
EPE HOS3 H  N N 120 
GLN N    N  N N 121 
GLN CA   C  N S 122 
GLN C    C  N N 123 
GLN O    O  N N 124 
GLN CB   C  N N 125 
GLN CG   C  N N 126 
GLN CD   C  N N 127 
GLN OE1  O  N N 128 
GLN NE2  N  N N 129 
GLN OXT  O  N N 130 
GLN H    H  N N 131 
GLN H2   H  N N 132 
GLN HA   H  N N 133 
GLN HB2  H  N N 134 
GLN HB3  H  N N 135 
GLN HG2  H  N N 136 
GLN HG3  H  N N 137 
GLN HE21 H  N N 138 
GLN HE22 H  N N 139 
GLN HXT  H  N N 140 
GLU N    N  N N 141 
GLU CA   C  N S 142 
GLU C    C  N N 143 
GLU O    O  N N 144 
GLU CB   C  N N 145 
GLU CG   C  N N 146 
GLU CD   C  N N 147 
GLU OE1  O  N N 148 
GLU OE2  O  N N 149 
GLU OXT  O  N N 150 
GLU H    H  N N 151 
GLU H2   H  N N 152 
GLU HA   H  N N 153 
GLU HB2  H  N N 154 
GLU HB3  H  N N 155 
GLU HG2  H  N N 156 
GLU HG3  H  N N 157 
GLU HE2  H  N N 158 
GLU HXT  H  N N 159 
GLY N    N  N N 160 
GLY CA   C  N N 161 
GLY C    C  N N 162 
GLY O    O  N N 163 
GLY OXT  O  N N 164 
GLY H    H  N N 165 
GLY H2   H  N N 166 
GLY HA2  H  N N 167 
GLY HA3  H  N N 168 
GLY HXT  H  N N 169 
HIS N    N  N N 170 
HIS CA   C  N S 171 
HIS C    C  N N 172 
HIS O    O  N N 173 
HIS CB   C  N N 174 
HIS CG   C  Y N 175 
HIS ND1  N  Y N 176 
HIS CD2  C  Y N 177 
HIS CE1  C  Y N 178 
HIS NE2  N  Y N 179 
HIS OXT  O  N N 180 
HIS H    H  N N 181 
HIS H2   H  N N 182 
HIS HA   H  N N 183 
HIS HB2  H  N N 184 
HIS HB3  H  N N 185 
HIS HD1  H  N N 186 
HIS HD2  H  N N 187 
HIS HE1  H  N N 188 
HIS HE2  H  N N 189 
HIS HXT  H  N N 190 
HOH O    O  N N 191 
HOH H1   H  N N 192 
HOH H2   H  N N 193 
ILE N    N  N N 194 
ILE CA   C  N S 195 
ILE C    C  N N 196 
ILE O    O  N N 197 
ILE CB   C  N S 198 
ILE CG1  C  N N 199 
ILE CG2  C  N N 200 
ILE CD1  C  N N 201 
ILE OXT  O  N N 202 
ILE H    H  N N 203 
ILE H2   H  N N 204 
ILE HA   H  N N 205 
ILE HB   H  N N 206 
ILE HG12 H  N N 207 
ILE HG13 H  N N 208 
ILE HG21 H  N N 209 
ILE HG22 H  N N 210 
ILE HG23 H  N N 211 
ILE HD11 H  N N 212 
ILE HD12 H  N N 213 
ILE HD13 H  N N 214 
ILE HXT  H  N N 215 
LEU N    N  N N 216 
LEU CA   C  N S 217 
LEU C    C  N N 218 
LEU O    O  N N 219 
LEU CB   C  N N 220 
LEU CG   C  N N 221 
LEU CD1  C  N N 222 
LEU CD2  C  N N 223 
LEU OXT  O  N N 224 
LEU H    H  N N 225 
LEU H2   H  N N 226 
LEU HA   H  N N 227 
LEU HB2  H  N N 228 
LEU HB3  H  N N 229 
LEU HG   H  N N 230 
LEU HD11 H  N N 231 
LEU HD12 H  N N 232 
LEU HD13 H  N N 233 
LEU HD21 H  N N 234 
LEU HD22 H  N N 235 
LEU HD23 H  N N 236 
LEU HXT  H  N N 237 
LYS N    N  N N 238 
LYS CA   C  N S 239 
LYS C    C  N N 240 
LYS O    O  N N 241 
LYS CB   C  N N 242 
LYS CG   C  N N 243 
LYS CD   C  N N 244 
LYS CE   C  N N 245 
LYS NZ   N  N N 246 
LYS OXT  O  N N 247 
LYS H    H  N N 248 
LYS H2   H  N N 249 
LYS HA   H  N N 250 
LYS HB2  H  N N 251 
LYS HB3  H  N N 252 
LYS HG2  H  N N 253 
LYS HG3  H  N N 254 
LYS HD2  H  N N 255 
LYS HD3  H  N N 256 
LYS HE2  H  N N 257 
LYS HE3  H  N N 258 
LYS HZ1  H  N N 259 
LYS HZ2  H  N N 260 
LYS HZ3  H  N N 261 
LYS HXT  H  N N 262 
MET N    N  N N 263 
MET CA   C  N S 264 
MET C    C  N N 265 
MET O    O  N N 266 
MET CB   C  N N 267 
MET CG   C  N N 268 
MET SD   S  N N 269 
MET CE   C  N N 270 
MET OXT  O  N N 271 
MET H    H  N N 272 
MET H2   H  N N 273 
MET HA   H  N N 274 
MET HB2  H  N N 275 
MET HB3  H  N N 276 
MET HG2  H  N N 277 
MET HG3  H  N N 278 
MET HE1  H  N N 279 
MET HE2  H  N N 280 
MET HE3  H  N N 281 
MET HXT  H  N N 282 
PEG C1   C  N N 283 
PEG O1   O  N N 284 
PEG C2   C  N N 285 
PEG O2   O  N N 286 
PEG C3   C  N N 287 
PEG C4   C  N N 288 
PEG O4   O  N N 289 
PEG H11  H  N N 290 
PEG H12  H  N N 291 
PEG HO1  H  N N 292 
PEG H21  H  N N 293 
PEG H22  H  N N 294 
PEG H31  H  N N 295 
PEG H32  H  N N 296 
PEG H41  H  N N 297 
PEG H42  H  N N 298 
PEG HO4  H  N N 299 
PHE N    N  N N 300 
PHE CA   C  N S 301 
PHE C    C  N N 302 
PHE O    O  N N 303 
PHE CB   C  N N 304 
PHE CG   C  Y N 305 
PHE CD1  C  Y N 306 
PHE CD2  C  Y N 307 
PHE CE1  C  Y N 308 
PHE CE2  C  Y N 309 
PHE CZ   C  Y N 310 
PHE OXT  O  N N 311 
PHE H    H  N N 312 
PHE H2   H  N N 313 
PHE HA   H  N N 314 
PHE HB2  H  N N 315 
PHE HB3  H  N N 316 
PHE HD1  H  N N 317 
PHE HD2  H  N N 318 
PHE HE1  H  N N 319 
PHE HE2  H  N N 320 
PHE HZ   H  N N 321 
PHE HXT  H  N N 322 
PRO N    N  N N 323 
PRO CA   C  N S 324 
PRO C    C  N N 325 
PRO O    O  N N 326 
PRO CB   C  N N 327 
PRO CG   C  N N 328 
PRO CD   C  N N 329 
PRO OXT  O  N N 330 
PRO H    H  N N 331 
PRO HA   H  N N 332 
PRO HB2  H  N N 333 
PRO HB3  H  N N 334 
PRO HG2  H  N N 335 
PRO HG3  H  N N 336 
PRO HD2  H  N N 337 
PRO HD3  H  N N 338 
PRO HXT  H  N N 339 
SER N    N  N N 340 
SER CA   C  N S 341 
SER C    C  N N 342 
SER O    O  N N 343 
SER CB   C  N N 344 
SER OG   O  N N 345 
SER OXT  O  N N 346 
SER H    H  N N 347 
SER H2   H  N N 348 
SER HA   H  N N 349 
SER HB2  H  N N 350 
SER HB3  H  N N 351 
SER HG   H  N N 352 
SER HXT  H  N N 353 
THR N    N  N N 354 
THR CA   C  N S 355 
THR C    C  N N 356 
THR O    O  N N 357 
THR CB   C  N R 358 
THR OG1  O  N N 359 
THR CG2  C  N N 360 
THR OXT  O  N N 361 
THR H    H  N N 362 
THR H2   H  N N 363 
THR HA   H  N N 364 
THR HB   H  N N 365 
THR HG1  H  N N 366 
THR HG21 H  N N 367 
THR HG22 H  N N 368 
THR HG23 H  N N 369 
THR HXT  H  N N 370 
TRP N    N  N N 371 
TRP CA   C  N S 372 
TRP C    C  N N 373 
TRP O    O  N N 374 
TRP CB   C  N N 375 
TRP CG   C  Y N 376 
TRP CD1  C  Y N 377 
TRP CD2  C  Y N 378 
TRP NE1  N  Y N 379 
TRP CE2  C  Y N 380 
TRP CE3  C  Y N 381 
TRP CZ2  C  Y N 382 
TRP CZ3  C  Y N 383 
TRP CH2  C  Y N 384 
TRP OXT  O  N N 385 
TRP H    H  N N 386 
TRP H2   H  N N 387 
TRP HA   H  N N 388 
TRP HB2  H  N N 389 
TRP HB3  H  N N 390 
TRP HD1  H  N N 391 
TRP HE1  H  N N 392 
TRP HE3  H  N N 393 
TRP HZ2  H  N N 394 
TRP HZ3  H  N N 395 
TRP HH2  H  N N 396 
TRP HXT  H  N N 397 
TYR N    N  N N 398 
TYR CA   C  N S 399 
TYR C    C  N N 400 
TYR O    O  N N 401 
TYR CB   C  N N 402 
TYR CG   C  Y N 403 
TYR CD1  C  Y N 404 
TYR CD2  C  Y N 405 
TYR CE1  C  Y N 406 
TYR CE2  C  Y N 407 
TYR CZ   C  Y N 408 
TYR OH   O  N N 409 
TYR OXT  O  N N 410 
TYR H    H  N N 411 
TYR H2   H  N N 412 
TYR HA   H  N N 413 
TYR HB2  H  N N 414 
TYR HB3  H  N N 415 
TYR HD1  H  N N 416 
TYR HD2  H  N N 417 
TYR HE1  H  N N 418 
TYR HE2  H  N N 419 
TYR HH   H  N N 420 
TYR HXT  H  N N 421 
VAL N    N  N N 422 
VAL CA   C  N S 423 
VAL C    C  N N 424 
VAL O    O  N N 425 
VAL CB   C  N N 426 
VAL CG1  C  N N 427 
VAL CG2  C  N N 428 
VAL OXT  O  N N 429 
VAL H    H  N N 430 
VAL H2   H  N N 431 
VAL HA   H  N N 432 
VAL HB   H  N N 433 
VAL HG11 H  N N 434 
VAL HG12 H  N N 435 
VAL HG13 H  N N 436 
VAL HG21 H  N N 437 
VAL HG22 H  N N 438 
VAL HG23 H  N N 439 
VAL HXT  H  N N 440 
YM0 C1   C  Y N 441 
YM0 C2   C  Y N 442 
YM0 C3   C  Y N 443 
YM0 C4   C  Y N 444 
YM0 C5   C  N N 445 
YM0 C6   C  N N 446 
YM0 N1   N  Y N 447 
YM0 N2   N  Y N 448 
YM0 N3   N  N N 449 
YM0 N4   N  N N 450 
YM0 N5   N  N N 451 
YM0 H1   H  N N 452 
YM0 H3   H  N N 453 
YM0 H2   H  N N 454 
ZN  ZN   ZN N N 455 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
EPE N1  C2   sing N N 83  
EPE N1  C6   sing N N 84  
EPE N1  C9   sing N N 85  
EPE C2  C3   sing N N 86  
EPE C2  H21  sing N N 87  
EPE C2  H22  sing N N 88  
EPE C3  N4   sing N N 89  
EPE C3  H31  sing N N 90  
EPE C3  H32  sing N N 91  
EPE N4  C5   sing N N 92  
EPE N4  C7   sing N N 93  
EPE C5  C6   sing N N 94  
EPE C5  H51  sing N N 95  
EPE C5  H52  sing N N 96  
EPE C6  H61  sing N N 97  
EPE C6  H62  sing N N 98  
EPE C7  C8   sing N N 99  
EPE C7  H71  sing N N 100 
EPE C7  H72  sing N N 101 
EPE C8  O8   sing N N 102 
EPE C8  H81  sing N N 103 
EPE C8  H82  sing N N 104 
EPE O8  HO8  sing N N 105 
EPE C9  C10  sing N N 106 
EPE C9  H91  sing N N 107 
EPE C9  H92  sing N N 108 
EPE C10 S    sing N N 109 
EPE C10 H101 sing N N 110 
EPE C10 H102 sing N N 111 
EPE S   O1S  doub N N 112 
EPE S   O2S  doub N N 113 
EPE S   O3S  sing N N 114 
EPE O3S HOS3 sing N N 115 
GLN N   CA   sing N N 116 
GLN N   H    sing N N 117 
GLN N   H2   sing N N 118 
GLN CA  C    sing N N 119 
GLN CA  CB   sing N N 120 
GLN CA  HA   sing N N 121 
GLN C   O    doub N N 122 
GLN C   OXT  sing N N 123 
GLN CB  CG   sing N N 124 
GLN CB  HB2  sing N N 125 
GLN CB  HB3  sing N N 126 
GLN CG  CD   sing N N 127 
GLN CG  HG2  sing N N 128 
GLN CG  HG3  sing N N 129 
GLN CD  OE1  doub N N 130 
GLN CD  NE2  sing N N 131 
GLN NE2 HE21 sing N N 132 
GLN NE2 HE22 sing N N 133 
GLN OXT HXT  sing N N 134 
GLU N   CA   sing N N 135 
GLU N   H    sing N N 136 
GLU N   H2   sing N N 137 
GLU CA  C    sing N N 138 
GLU CA  CB   sing N N 139 
GLU CA  HA   sing N N 140 
GLU C   O    doub N N 141 
GLU C   OXT  sing N N 142 
GLU CB  CG   sing N N 143 
GLU CB  HB2  sing N N 144 
GLU CB  HB3  sing N N 145 
GLU CG  CD   sing N N 146 
GLU CG  HG2  sing N N 147 
GLU CG  HG3  sing N N 148 
GLU CD  OE1  doub N N 149 
GLU CD  OE2  sing N N 150 
GLU OE2 HE2  sing N N 151 
GLU OXT HXT  sing N N 152 
GLY N   CA   sing N N 153 
GLY N   H    sing N N 154 
GLY N   H2   sing N N 155 
GLY CA  C    sing N N 156 
GLY CA  HA2  sing N N 157 
GLY CA  HA3  sing N N 158 
GLY C   O    doub N N 159 
GLY C   OXT  sing N N 160 
GLY OXT HXT  sing N N 161 
HIS N   CA   sing N N 162 
HIS N   H    sing N N 163 
HIS N   H2   sing N N 164 
HIS CA  C    sing N N 165 
HIS CA  CB   sing N N 166 
HIS CA  HA   sing N N 167 
HIS C   O    doub N N 168 
HIS C   OXT  sing N N 169 
HIS CB  CG   sing N N 170 
HIS CB  HB2  sing N N 171 
HIS CB  HB3  sing N N 172 
HIS CG  ND1  sing Y N 173 
HIS CG  CD2  doub Y N 174 
HIS ND1 CE1  doub Y N 175 
HIS ND1 HD1  sing N N 176 
HIS CD2 NE2  sing Y N 177 
HIS CD2 HD2  sing N N 178 
HIS CE1 NE2  sing Y N 179 
HIS CE1 HE1  sing N N 180 
HIS NE2 HE2  sing N N 181 
HIS OXT HXT  sing N N 182 
HOH O   H1   sing N N 183 
HOH O   H2   sing N N 184 
ILE N   CA   sing N N 185 
ILE N   H    sing N N 186 
ILE N   H2   sing N N 187 
ILE CA  C    sing N N 188 
ILE CA  CB   sing N N 189 
ILE CA  HA   sing N N 190 
ILE C   O    doub N N 191 
ILE C   OXT  sing N N 192 
ILE CB  CG1  sing N N 193 
ILE CB  CG2  sing N N 194 
ILE CB  HB   sing N N 195 
ILE CG1 CD1  sing N N 196 
ILE CG1 HG12 sing N N 197 
ILE CG1 HG13 sing N N 198 
ILE CG2 HG21 sing N N 199 
ILE CG2 HG22 sing N N 200 
ILE CG2 HG23 sing N N 201 
ILE CD1 HD11 sing N N 202 
ILE CD1 HD12 sing N N 203 
ILE CD1 HD13 sing N N 204 
ILE OXT HXT  sing N N 205 
LEU N   CA   sing N N 206 
LEU N   H    sing N N 207 
LEU N   H2   sing N N 208 
LEU CA  C    sing N N 209 
LEU CA  CB   sing N N 210 
LEU CA  HA   sing N N 211 
LEU C   O    doub N N 212 
LEU C   OXT  sing N N 213 
LEU CB  CG   sing N N 214 
LEU CB  HB2  sing N N 215 
LEU CB  HB3  sing N N 216 
LEU CG  CD1  sing N N 217 
LEU CG  CD2  sing N N 218 
LEU CG  HG   sing N N 219 
LEU CD1 HD11 sing N N 220 
LEU CD1 HD12 sing N N 221 
LEU CD1 HD13 sing N N 222 
LEU CD2 HD21 sing N N 223 
LEU CD2 HD22 sing N N 224 
LEU CD2 HD23 sing N N 225 
LEU OXT HXT  sing N N 226 
LYS N   CA   sing N N 227 
LYS N   H    sing N N 228 
LYS N   H2   sing N N 229 
LYS CA  C    sing N N 230 
LYS CA  CB   sing N N 231 
LYS CA  HA   sing N N 232 
LYS C   O    doub N N 233 
LYS C   OXT  sing N N 234 
LYS CB  CG   sing N N 235 
LYS CB  HB2  sing N N 236 
LYS CB  HB3  sing N N 237 
LYS CG  CD   sing N N 238 
LYS CG  HG2  sing N N 239 
LYS CG  HG3  sing N N 240 
LYS CD  CE   sing N N 241 
LYS CD  HD2  sing N N 242 
LYS CD  HD3  sing N N 243 
LYS CE  NZ   sing N N 244 
LYS CE  HE2  sing N N 245 
LYS CE  HE3  sing N N 246 
LYS NZ  HZ1  sing N N 247 
LYS NZ  HZ2  sing N N 248 
LYS NZ  HZ3  sing N N 249 
LYS OXT HXT  sing N N 250 
MET N   CA   sing N N 251 
MET N   H    sing N N 252 
MET N   H2   sing N N 253 
MET CA  C    sing N N 254 
MET CA  CB   sing N N 255 
MET CA  HA   sing N N 256 
MET C   O    doub N N 257 
MET C   OXT  sing N N 258 
MET CB  CG   sing N N 259 
MET CB  HB2  sing N N 260 
MET CB  HB3  sing N N 261 
MET CG  SD   sing N N 262 
MET CG  HG2  sing N N 263 
MET CG  HG3  sing N N 264 
MET SD  CE   sing N N 265 
MET CE  HE1  sing N N 266 
MET CE  HE2  sing N N 267 
MET CE  HE3  sing N N 268 
MET OXT HXT  sing N N 269 
PEG C1  O1   sing N N 270 
PEG C1  C2   sing N N 271 
PEG C1  H11  sing N N 272 
PEG C1  H12  sing N N 273 
PEG O1  HO1  sing N N 274 
PEG C2  O2   sing N N 275 
PEG C2  H21  sing N N 276 
PEG C2  H22  sing N N 277 
PEG O2  C3   sing N N 278 
PEG C3  C4   sing N N 279 
PEG C3  H31  sing N N 280 
PEG C3  H32  sing N N 281 
PEG C4  O4   sing N N 282 
PEG C4  H41  sing N N 283 
PEG C4  H42  sing N N 284 
PEG O4  HO4  sing N N 285 
PHE N   CA   sing N N 286 
PHE N   H    sing N N 287 
PHE N   H2   sing N N 288 
PHE CA  C    sing N N 289 
PHE CA  CB   sing N N 290 
PHE CA  HA   sing N N 291 
PHE C   O    doub N N 292 
PHE C   OXT  sing N N 293 
PHE CB  CG   sing N N 294 
PHE CB  HB2  sing N N 295 
PHE CB  HB3  sing N N 296 
PHE CG  CD1  doub Y N 297 
PHE CG  CD2  sing Y N 298 
PHE CD1 CE1  sing Y N 299 
PHE CD1 HD1  sing N N 300 
PHE CD2 CE2  doub Y N 301 
PHE CD2 HD2  sing N N 302 
PHE CE1 CZ   doub Y N 303 
PHE CE1 HE1  sing N N 304 
PHE CE2 CZ   sing Y N 305 
PHE CE2 HE2  sing N N 306 
PHE CZ  HZ   sing N N 307 
PHE OXT HXT  sing N N 308 
PRO N   CA   sing N N 309 
PRO N   CD   sing N N 310 
PRO N   H    sing N N 311 
PRO CA  C    sing N N 312 
PRO CA  CB   sing N N 313 
PRO CA  HA   sing N N 314 
PRO C   O    doub N N 315 
PRO C   OXT  sing N N 316 
PRO CB  CG   sing N N 317 
PRO CB  HB2  sing N N 318 
PRO CB  HB3  sing N N 319 
PRO CG  CD   sing N N 320 
PRO CG  HG2  sing N N 321 
PRO CG  HG3  sing N N 322 
PRO CD  HD2  sing N N 323 
PRO CD  HD3  sing N N 324 
PRO OXT HXT  sing N N 325 
SER N   CA   sing N N 326 
SER N   H    sing N N 327 
SER N   H2   sing N N 328 
SER CA  C    sing N N 329 
SER CA  CB   sing N N 330 
SER CA  HA   sing N N 331 
SER C   O    doub N N 332 
SER C   OXT  sing N N 333 
SER CB  OG   sing N N 334 
SER CB  HB2  sing N N 335 
SER CB  HB3  sing N N 336 
SER OG  HG   sing N N 337 
SER OXT HXT  sing N N 338 
THR N   CA   sing N N 339 
THR N   H    sing N N 340 
THR N   H2   sing N N 341 
THR CA  C    sing N N 342 
THR CA  CB   sing N N 343 
THR CA  HA   sing N N 344 
THR C   O    doub N N 345 
THR C   OXT  sing N N 346 
THR CB  OG1  sing N N 347 
THR CB  CG2  sing N N 348 
THR CB  HB   sing N N 349 
THR OG1 HG1  sing N N 350 
THR CG2 HG21 sing N N 351 
THR CG2 HG22 sing N N 352 
THR CG2 HG23 sing N N 353 
THR OXT HXT  sing N N 354 
TRP N   CA   sing N N 355 
TRP N   H    sing N N 356 
TRP N   H2   sing N N 357 
TRP CA  C    sing N N 358 
TRP CA  CB   sing N N 359 
TRP CA  HA   sing N N 360 
TRP C   O    doub N N 361 
TRP C   OXT  sing N N 362 
TRP CB  CG   sing N N 363 
TRP CB  HB2  sing N N 364 
TRP CB  HB3  sing N N 365 
TRP CG  CD1  doub Y N 366 
TRP CG  CD2  sing Y N 367 
TRP CD1 NE1  sing Y N 368 
TRP CD1 HD1  sing N N 369 
TRP CD2 CE2  doub Y N 370 
TRP CD2 CE3  sing Y N 371 
TRP NE1 CE2  sing Y N 372 
TRP NE1 HE1  sing N N 373 
TRP CE2 CZ2  sing Y N 374 
TRP CE3 CZ3  doub Y N 375 
TRP CE3 HE3  sing N N 376 
TRP CZ2 CH2  doub Y N 377 
TRP CZ2 HZ2  sing N N 378 
TRP CZ3 CH2  sing Y N 379 
TRP CZ3 HZ3  sing N N 380 
TRP CH2 HH2  sing N N 381 
TRP OXT HXT  sing N N 382 
TYR N   CA   sing N N 383 
TYR N   H    sing N N 384 
TYR N   H2   sing N N 385 
TYR CA  C    sing N N 386 
TYR CA  CB   sing N N 387 
TYR CA  HA   sing N N 388 
TYR C   O    doub N N 389 
TYR C   OXT  sing N N 390 
TYR CB  CG   sing N N 391 
TYR CB  HB2  sing N N 392 
TYR CB  HB3  sing N N 393 
TYR CG  CD1  doub Y N 394 
TYR CG  CD2  sing Y N 395 
TYR CD1 CE1  sing Y N 396 
TYR CD1 HD1  sing N N 397 
TYR CD2 CE2  doub Y N 398 
TYR CD2 HD2  sing N N 399 
TYR CE1 CZ   doub Y N 400 
TYR CE1 HE1  sing N N 401 
TYR CE2 CZ   sing Y N 402 
TYR CE2 HE2  sing N N 403 
TYR CZ  OH   sing N N 404 
TYR OH  HH   sing N N 405 
TYR OXT HXT  sing N N 406 
VAL N   CA   sing N N 407 
VAL N   H    sing N N 408 
VAL N   H2   sing N N 409 
VAL CA  C    sing N N 410 
VAL CA  CB   sing N N 411 
VAL CA  HA   sing N N 412 
VAL C   O    doub N N 413 
VAL C   OXT  sing N N 414 
VAL CB  CG1  sing N N 415 
VAL CB  CG2  sing N N 416 
VAL CB  HB   sing N N 417 
VAL CG1 HG11 sing N N 418 
VAL CG1 HG12 sing N N 419 
VAL CG1 HG13 sing N N 420 
VAL CG2 HG21 sing N N 421 
VAL CG2 HG22 sing N N 422 
VAL CG2 HG23 sing N N 423 
VAL OXT HXT  sing N N 424 
YM0 C1  C2   doub Y N 425 
YM0 C1  N2   sing Y N 426 
YM0 C1  N3   sing N N 427 
YM0 C2  N1   sing Y N 428 
YM0 C2  C5   sing N N 429 
YM0 N1  C3   doub Y N 430 
YM0 C3  C4   sing Y N 431 
YM0 C3  C6   sing N N 432 
YM0 C4  N2   doub Y N 433 
YM0 C5  N4   trip N N 434 
YM0 C6  N5   trip N N 435 
YM0 C4  H1   sing N N 436 
YM0 N3  H3   sing N N 437 
YM0 N3  H2   sing N N 438 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   8a92 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 21 21 21' 
_space_group.name_Hall        'P 2ac 2ab' 
_space_group.IT_number        19 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8RBC 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.015172 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.014067 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009341 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356  2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032  2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882  3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732  6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
ZN ? ? 24.64596 5.25405 ? ? 2.14387  29.76375 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . SER A 1 2   ? -16.99945 8.59231   -19.33552 1.000 78.18585  ? 95  SER A N   1 
ATOM   2    C  CA  . SER A 1 2   ? -15.90051 9.23142   -18.61122 1.000 77.54377  ? 95  SER A CA  1 
ATOM   3    C  C   . SER A 1 2   ? -16.17929 10.70654  -18.33911 1.000 79.98989  ? 95  SER A C   1 
ATOM   4    O  O   . SER A 1 2   ? -16.36648 11.48839  -19.28070 1.000 76.74762  ? 95  SER A O   1 
ATOM   5    C  CB  . SER A 1 2   ? -14.58945 9.08561   -19.38655 1.000 73.73908  ? 95  SER A CB  1 
ATOM   6    O  OG  . SER A 1 2   ? -13.48126 9.07543   -18.50227 1.000 74.16428  ? 95  SER A OG  1 
ATOM   7    N  N   . SER A 1 3   ? -16.16456 11.06706  -17.04893 1.000 78.56761  ? 96  SER A N   1 
ATOM   8    C  CA  . SER A 1 3   ? -16.55887 12.39807  -16.59437 1.000 77.62309  ? 96  SER A CA  1 
ATOM   9    C  C   . SER A 1 3   ? -15.76320 13.47535  -17.31179 1.000 80.35727  ? 96  SER A C   1 
ATOM   10   O  O   . SER A 1 3   ? -14.54094 13.36801  -17.46630 1.000 79.35377  ? 96  SER A O   1 
ATOM   11   C  CB  . SER A 1 3   ? -16.35260 12.52262  -15.08249 1.000 79.57352  ? 96  SER A CB  1 
ATOM   12   O  OG  . SER A 1 3   ? -16.61889 11.29153  -14.42569 1.000 74.57156  ? 96  SER A OG  1 
ATOM   13   N  N   . VAL A 1 4   ? -16.47009 14.49653  -17.77939 1.000 71.09217  ? 97  VAL A N   1 
ATOM   14   C  CA  . VAL A 1 4   ? -15.88691 15.52246  -18.63397 1.000 68.17408  ? 97  VAL A CA  1 
ATOM   15   C  C   . VAL A 1 4   ? -15.28093 16.59137  -17.73204 1.000 65.51332  ? 97  VAL A C   1 
ATOM   16   O  O   . VAL A 1 4   ? -16.00569 17.17293  -16.90268 1.000 65.37474  ? 97  VAL A O   1 
ATOM   17   C  CB  . VAL A 1 4   ? -16.91809 16.11572  -19.59804 1.000 68.85165  ? 97  VAL A CB  1 
ATOM   18   C  CG1 . VAL A 1 4   ? -16.54549 17.52634  -19.96983 1.000 69.19229  ? 97  VAL A CG1 1 
ATOM   19   C  CG2 . VAL A 1 4   ? -16.99705 15.24246  -20.84730 1.000 68.00101  ? 97  VAL A CG2 1 
ATOM   20   N  N   . PRO A 1 5   ? -13.98414 16.83829  -17.81781 1.000 56.69587  ? 98  PRO A N   1 
ATOM   21   C  CA  . PRO A 1 5   ? -13.38869 17.89396  -17.00405 1.000 58.97198  ? 98  PRO A CA  1 
ATOM   22   C  C   . PRO A 1 5   ? -13.84589 19.25333  -17.49265 1.000 58.06795  ? 98  PRO A C   1 
ATOM   23   O  O   . PRO A 1 5   ? -14.09366 19.46487  -18.68196 1.000 57.70157  ? 98  PRO A O   1 
ATOM   24   C  CB  . PRO A 1 5   ? -11.88133 17.70075  -17.19595 1.000 56.79661  ? 98  PRO A CB  1 
ATOM   25   C  CG  . PRO A 1 5   ? -11.71507 16.68924  -18.30362 1.000 68.58571  ? 98  PRO A CG  1 
ATOM   26   C  CD  . PRO A 1 5   ? -13.05063 16.24184  -18.78359 1.000 63.28707  ? 98  PRO A CD  1 
ATOM   27   N  N   . SER A 1 6   ? -13.98952 20.16996  -16.54629 1.000 59.21353  ? 99  SER A N   1 
ATOM   28   C  CA  . SER A 1 6   ? -14.33928 21.53302  -16.89096 1.000 54.03266  ? 99  SER A CA  1 
ATOM   29   C  C   . SER A 1 6   ? -13.20166 22.17432  -17.66933 1.000 55.57388  ? 99  SER A C   1 
ATOM   30   O  O   . SER A 1 6   ? -12.03072 22.01890  -17.32046 1.000 53.68528  ? 99  SER A O   1 
ATOM   31   C  CB  . SER A 1 6   ? -14.62986 22.33215  -15.62653 1.000 66.13083  ? 99  SER A CB  1 
ATOM   32   O  OG  . SER A 1 6   ? -15.33704 23.51878  -15.93434 1.000 70.49518  ? 99  SER A OG  1 
ATOM   33   N  N   . GLN A 1 7   ? -13.54709 22.88117  -18.74120 1.000 56.22990  ? 100 GLN A N   1 
ATOM   34   C  CA  . GLN A 1 7   ? -12.57899 23.68850  -19.46858 1.000 60.81405  ? 100 GLN A CA  1 
ATOM   35   C  C   . GLN A 1 7   ? -12.77572 25.18114  -19.23797 1.000 54.92694  ? 100 GLN A C   1 
ATOM   36   O  O   . GLN A 1 7   ? -12.19521 25.98799  -19.96953 1.000 54.72868  ? 100 GLN A O   1 
ATOM   37   C  CB  . GLN A 1 7   ? -12.63194 23.37845  -20.96498 1.000 63.20204  ? 100 GLN A CB  1 
ATOM   38   C  CG  . GLN A 1 7   ? -13.82885 23.95772  -21.70588 1.000 66.09998  ? 100 GLN A CG  1 
ATOM   39   C  CD  . GLN A 1 7   ? -14.12839 23.19321  -22.97004 1.000 71.68935  ? 100 GLN A CD  1 
ATOM   40   O  OE1 . GLN A 1 7   ? -13.90166 23.68291  -24.08075 1.000 77.55090  ? 100 GLN A OE1 1 
ATOM   41   N  NE2 . GLN A 1 7   ? -14.62336 21.97163  -22.81169 1.000 77.62630  ? 100 GLN A NE2 1 
ATOM   42   N  N   . LYS A 1 8   ? -13.57352 25.56809  -18.24089 1.000 55.30636  ? 101 LYS A N   1 
ATOM   43   C  CA  . LYS A 1 8   ? -13.89857 26.97181  -18.03283 1.000 53.16478  ? 101 LYS A CA  1 
ATOM   44   C  C   . LYS A 1 8   ? -12.72645 27.68486  -17.38359 1.000 55.16186  ? 101 LYS A C   1 
ATOM   45   O  O   . LYS A 1 8   ? -12.20539 27.23127  -16.35811 1.000 48.56441  ? 101 LYS A O   1 
ATOM   46   C  CB  . LYS A 1 8   ? -15.14678 27.12689  -17.16392 1.000 51.07684  ? 101 LYS A CB  1 
ATOM   47   C  CG  . LYS A 1 8   ? -15.85153 28.46600  -17.33227 1.000 57.17712  ? 101 LYS A CG  1 
ATOM   48   N  N   . THR A 1 9   ? -12.32315 28.80543  -17.98544 1.000 45.98967  ? 102 THR A N   1 
ATOM   49   C  CA  . THR A 1 9   ? -11.23521 29.60999  -17.45051 1.000 41.13291  ? 102 THR A CA  1 
ATOM   50   C  C   . THR A 1 9   ? -11.61258 30.14961  -16.07977 1.000 43.94220  ? 102 THR A C   1 
ATOM   51   O  O   . THR A 1 9   ? -12.76048 30.52561  -15.83780 1.000 52.85932  ? 102 THR A O   1 
ATOM   52   C  CB  . THR A 1 9   ? -10.92685 30.75733  -18.41233 1.000 42.28525  ? 102 THR A CB  1 
ATOM   53   O  OG1 . THR A 1 9   ? -10.85068 30.24684  -19.74969 1.000 50.00797  ? 102 THR A OG1 1 
ATOM   54   C  CG2 . THR A 1 9   ? -9.61563  31.44227  -18.05599 1.000 45.14732  ? 102 THR A CG2 1 
ATOM   55   N  N   . TYR A 1 10  ? -10.65051 30.16156  -15.16525 1.000 42.85502  ? 103 TYR A N   1 
ATOM   56   C  CA  . TYR A 1 10  ? -10.96513 30.53311  -13.79314 1.000 37.74265  ? 103 TYR A CA  1 
ATOM   57   C  C   . TYR A 1 10  ? -9.67475  31.01891  -13.15682 1.000 44.43057  ? 103 TYR A C   1 
ATOM   58   O  O   . TYR A 1 10  ? -8.79794  30.21399  -12.84940 1.000 40.98172  ? 103 TYR A O   1 
ATOM   59   C  CB  . TYR A 1 10  ? -11.56371 29.34227  -13.03577 1.000 43.15129  ? 103 TYR A CB  1 
ATOM   60   C  CG  . TYR A 1 10  ? -11.72788 29.57706  -11.54996 1.000 51.16688  ? 103 TYR A CG  1 
ATOM   61   C  CD1 . TYR A 1 10  ? -12.59718 30.54893  -11.07554 1.000 48.72005  ? 103 TYR A CD1 1 
ATOM   62   C  CD2 . TYR A 1 10  ? -11.01794 28.82463  -10.62232 1.000 49.50388  ? 103 TYR A CD2 1 
ATOM   63   C  CE1 . TYR A 1 10  ? -12.75006 30.77749  -9.71613  1.000 50.52464  ? 103 TYR A CE1 1 
ATOM   64   C  CE2 . TYR A 1 10  ? -11.16934 29.04247  -9.25427  1.000 57.62749  ? 103 TYR A CE2 1 
ATOM   65   C  CZ  . TYR A 1 10  ? -12.03944 30.02468  -8.81228  1.000 56.44049  ? 103 TYR A CZ  1 
ATOM   66   O  OH  . TYR A 1 10  ? -12.20204 30.25880  -7.46507  1.000 61.01428  ? 103 TYR A OH  1 
ATOM   67   N  N   . GLN A 1 11  ? -9.55948  32.32755  -12.96165 1.000 40.73720  ? 104 GLN A N   1 
ATOM   68   C  CA  . GLN A 1 11  ? -8.31725  32.87198  -12.44740 1.000 39.81708  ? 104 GLN A CA  1 
ATOM   69   C  C   . GLN A 1 11  ? -8.15536  32.57018  -10.97366 1.000 42.77355  ? 104 GLN A C   1 
ATOM   70   O  O   . GLN A 1 11  ? -7.02251  32.46727  -10.48156 1.000 43.22866  ? 104 GLN A O   1 
ATOM   71   C  CB  . GLN A 1 11  ? -8.28317  34.38808  -12.67424 1.000 44.95888  ? 104 GLN A CB  1 
ATOM   72   C  CG  . GLN A 1 11  ? -8.24330  34.78943  -14.14232 1.000 43.79406  ? 104 GLN A CG  1 
ATOM   73   C  CD  . GLN A 1 11  ? -7.71868  36.19326  -14.32539 1.000 56.78139  ? 104 GLN A CD  1 
ATOM   74   O  OE1 . GLN A 1 11  ? -7.72742  36.99423  -13.39015 1.000 61.63207  ? 104 GLN A OE1 1 
ATOM   75   N  NE2 . GLN A 1 11  ? -7.22943  36.49380  -15.52153 1.000 67.94580  ? 104 GLN A NE2 1 
ATOM   76   N  N   . GLY A 1 12  ? -9.26749  32.48453  -10.25033 1.000 41.27978  ? 105 GLY A N   1 
ATOM   77   C  CA  . GLY A 1 12  ? -9.25066  32.14107  -8.85052  1.000 43.80701  ? 105 GLY A CA  1 
ATOM   78   C  C   . GLY A 1 12  ? -8.58188  33.20235  -7.99489  1.000 49.19032  ? 105 GLY A C   1 
ATOM   79   O  O   . GLY A 1 12  ? -8.22346  34.28812  -8.44541  1.000 45.83291  ? 105 GLY A O   1 
ATOM   80   N  N   . SER A 1 13  ? -8.37052  32.82662  -6.73176  1.000 45.87251  ? 106 SER A N   1 
ATOM   81   C  CA  . SER A 1 13  ? -7.85723  33.76242  -5.73678  1.000 48.60574  ? 106 SER A CA  1 
ATOM   82   C  C   . SER A 1 13  ? -6.47836  34.29028  -6.07970  1.000 50.10693  ? 106 SER A C   1 
ATOM   83   O  O   . SER A 1 13  ? -6.09904  35.36763  -5.61048  1.000 49.67233  ? 106 SER A O   1 
ATOM   84   C  CB  . SER A 1 13  ? -7.78759  33.09163  -4.36365  1.000 44.14523  ? 106 SER A CB  1 
ATOM   85   O  OG  . SER A 1 13  ? -9.07195  32.72998  -3.91272  1.000 57.09770  ? 106 SER A OG  1 
ATOM   86   N  N   . TYR A 1 14  ? -5.68626  33.54151  -6.83373  1.000 43.54587  ? 107 TYR A N   1 
ATOM   87   C  CA  . TYR A 1 14  ? -4.30603  33.94637  -7.04374  1.000 43.27824  ? 107 TYR A CA  1 
ATOM   88   C  C   . TYR A 1 14  ? -4.09845  34.60011  -8.39421  1.000 37.16617  ? 107 TYR A C   1 
ATOM   89   O  O   . TYR A 1 14  ? -2.95918  34.92703  -8.74354  1.000 48.20927  ? 107 TYR A O   1 
ATOM   90   C  CB  . TYR A 1 14  ? -3.36536  32.75064  -6.84540  1.000 41.71284  ? 107 TYR A CB  1 
ATOM   91   C  CG  . TYR A 1 14  ? -3.50518  32.16868  -5.45098  1.000 53.18778  ? 107 TYR A CG  1 
ATOM   92   C  CD1 . TYR A 1 14  ? -2.81438  32.72515  -4.38071  1.000 46.12860  ? 107 TYR A CD1 1 
ATOM   93   C  CD2 . TYR A 1 14  ? -4.33899  31.07172  -5.19763  1.000 52.45353  ? 107 TYR A CD2 1 
ATOM   94   C  CE1 . TYR A 1 14  ? -2.94253  32.21726  -3.09252  1.000 47.80144  ? 107 TYR A CE1 1 
ATOM   95   C  CE2 . TYR A 1 14  ? -4.47260  30.55165  -3.90073  1.000 52.16403  ? 107 TYR A CE2 1 
ATOM   96   C  CZ  . TYR A 1 14  ? -3.77151  31.14176  -2.85404  1.000 51.53137  ? 107 TYR A CZ  1 
ATOM   97   O  OH  . TYR A 1 14  ? -3.87536  30.65728  -1.56488  1.000 59.90876  ? 107 TYR A OH  1 
ATOM   98   N  N   . GLY A 1 15  ? -5.17306  34.84713  -9.13743  1.000 46.54790  ? 108 GLY A N   1 
ATOM   99   C  CA  . GLY A 1 15  ? -5.04453  35.48627  -10.44629 1.000 46.56929  ? 108 GLY A CA  1 
ATOM   100  C  C   . GLY A 1 15  ? -4.25702  34.66255  -11.44245 1.000 46.25256  ? 108 GLY A C   1 
ATOM   101  O  O   . GLY A 1 15  ? -3.40874  35.20642  -12.15837 1.000 41.50948  ? 108 GLY A O   1 
ATOM   102  N  N   . PHE A 1 16  ? -4.51715  33.35546  -11.49662 1.000 42.07126  ? 109 PHE A N   1 
ATOM   103  C  CA  . PHE A 1 16  ? -3.73347  32.43287  -12.31453 1.000 43.68515  ? 109 PHE A CA  1 
ATOM   104  C  C   . PHE A 1 16  ? -4.08273  32.57759  -13.79042 1.000 41.70845  ? 109 PHE A C   1 
ATOM   105  O  O   . PHE A 1 16  ? -5.26128  32.59855  -14.15658 1.000 45.57215  ? 109 PHE A O   1 
ATOM   106  C  CB  . PHE A 1 16  ? -4.00380  31.00464  -11.83353 1.000 44.06690  ? 109 PHE A CB  1 
ATOM   107  C  CG  . PHE A 1 16  ? -3.34241  29.91807  -12.64324 1.000 40.15729  ? 109 PHE A CG  1 
ATOM   108  C  CD1 . PHE A 1 16  ? -1.99249  29.63425  -12.49056 1.000 42.96216  ? 109 PHE A CD1 1 
ATOM   109  C  CD2 . PHE A 1 16  ? -4.09237  29.12490  -13.49379 1.000 37.67071  ? 109 PHE A CD2 1 
ATOM   110  C  CE1 . PHE A 1 16  ? -1.39154  28.60727  -13.21670 1.000 40.72015  ? 109 PHE A CE1 1 
ATOM   111  C  CE2 . PHE A 1 16  ? -3.50030  28.09359  -14.21938 1.000 41.48284  ? 109 PHE A CE2 1 
ATOM   112  C  CZ  . PHE A 1 16  ? -2.15197  27.83295  -14.08000 1.000 38.54408  ? 109 PHE A CZ  1 
ATOM   113  N  N   . ARG A 1 17  ? -3.05949  32.65946  -14.64397 1.000 34.19810  ? 110 ARG A N   1 
ATOM   114  C  CA  . ARG A 1 17  ? -3.26746  32.72857  -16.08839 1.000 36.02832  ? 110 ARG A CA  1 
ATOM   115  C  C   . ARG A 1 17  ? -2.02355  32.20050  -16.79978 1.000 37.64801  ? 110 ARG A C   1 
ATOM   116  O  O   . ARG A 1 17  ? -0.91495  32.26402  -16.26017 1.000 40.61838  ? 110 ARG A O   1 
ATOM   117  C  CB  . ARG A 1 17  ? -3.58913  34.16387  -16.53220 1.000 46.87204  ? 110 ARG A CB  1 
ATOM   118  C  CG  . ARG A 1 17  ? -2.60143  35.21038  -15.99302 1.000 44.72868  ? 110 ARG A CG  1 
ATOM   119  C  CD  . ARG A 1 17  ? -3.26321  36.47510  -15.51243 1.000 51.98274  ? 110 ARG A CD  1 
ATOM   120  N  NE  . ARG A 1 17  ? -2.41295  37.19914  -14.56757 1.000 65.88101  ? 110 ARG A NE  1 
ATOM   121  N  N   . LEU A 1 18  ? -2.21899  31.66475  -18.00625 1.000 33.79652  ? 111 LEU A N   1 
ATOM   122  C  CA  . LEU A 1 18  ? -1.11024  31.21355  -18.84289 1.000 40.12248  ? 111 LEU A CA  1 
ATOM   123  C  C   . LEU A 1 18  ? -0.62324  32.33613  -19.75653 1.000 44.77475  ? 111 LEU A C   1 
ATOM   124  O  O   . LEU A 1 18  ? -1.35743  33.26912  -20.08520 1.000 42.83501  ? 111 LEU A O   1 
ATOM   125  C  CB  . LEU A 1 18  ? -1.51158  30.01976  -19.72130 1.000 36.22347  ? 111 LEU A CB  1 
ATOM   126  C  CG  . LEU A 1 18  ? -2.15821  28.83780  -19.01867 1.000 43.64064  ? 111 LEU A CG  1 
ATOM   127  C  CD1 . LEU A 1 18  ? -2.59859  27.74613  -19.99533 1.000 40.62561  ? 111 LEU A CD1 1 
ATOM   128  C  CD2 . LEU A 1 18  ? -1.25804  28.27768  -17.93159 1.000 40.75767  ? 111 LEU A CD2 1 
ATOM   129  N  N   . GLY A 1 19  ? 0.62931   32.21686  -20.17850 1.000 39.77997  ? 112 GLY A N   1 
ATOM   130  C  CA  . GLY A 1 19  ? 1.17856   33.09742  -21.18431 1.000 37.53743  ? 112 GLY A CA  1 
ATOM   131  C  C   . GLY A 1 19  ? 2.20554   32.35645  -22.00676 1.000 47.10309  ? 112 GLY A C   1 
ATOM   132  O  O   . GLY A 1 19  ? 2.75558   31.33178  -21.58358 1.000 44.43915  ? 112 GLY A O   1 
ATOM   133  N  N   . PHE A 1 20  ? 2.44129   32.87602  -23.20875 1.000 40.27736  ? 113 PHE A N   1 
ATOM   134  C  CA  . PHE A 1 20  ? 3.44003   32.32541  -24.11297 1.000 41.99670  ? 113 PHE A CA  1 
ATOM   135  C  C   . PHE A 1 20  ? 4.29582   33.46982  -24.62021 1.000 46.53582  ? 113 PHE A C   1 
ATOM   136  O  O   . PHE A 1 20  ? 3.78066   34.55512  -24.87466 1.000 41.53666  ? 113 PHE A O   1 
ATOM   137  C  CB  . PHE A 1 20  ? 2.79497   31.59892  -25.30001 1.000 39.56684  ? 113 PHE A CB  1 
ATOM   138  C  CG  . PHE A 1 20  ? 1.91132   30.44793  -24.90797 1.000 37.13740  ? 113 PHE A CG  1 
ATOM   139  C  CD1 . PHE A 1 20  ? 0.60285   30.67063  -24.49995 1.000 42.04267  ? 113 PHE A CD1 1 
ATOM   140  C  CD2 . PHE A 1 20  ? 2.38877   29.14634  -24.94063 1.000 46.36282  ? 113 PHE A CD2 1 
ATOM   141  C  CE1 . PHE A 1 20  ? -0.21438  29.61475  -24.12904 1.000 46.84498  ? 113 PHE A CE1 1 
ATOM   142  C  CE2 . PHE A 1 20  ? 1.57096   28.08111  -24.57830 1.000 37.06174  ? 113 PHE A CE2 1 
ATOM   143  C  CZ  . PHE A 1 20  ? 0.26958   28.31881  -24.17210 1.000 40.49833  ? 113 PHE A CZ  1 
ATOM   144  N  N   . LEU A 1 21  ? 5.58983   33.22987  -24.77637 1.000 46.95246  ? 114 LEU A N   1 
ATOM   145  C  CA  . LEU A 1 21  ? 6.44859   34.23316  -25.38775 1.000 53.47051  ? 114 LEU A CA  1 
ATOM   146  C  C   . LEU A 1 21  ? 6.34044   34.18662  -26.91783 1.000 60.48480  ? 114 LEU A C   1 
ATOM   147  O  O   . LEU A 1 21  ? 5.94252   33.17569  -27.50277 1.000 53.60603  ? 114 LEU A O   1 
ATOM   148  C  CB  . LEU A 1 21  ? 7.89537   34.02744  -24.93902 1.000 53.73763  ? 114 LEU A CB  1 
ATOM   149  C  CG  . LEU A 1 21  ? 8.15757   34.07200  -23.43124 1.000 53.10308  ? 114 LEU A CG  1 
ATOM   150  C  CD1 . LEU A 1 21  ? 9.56255   33.57949  -23.14849 1.000 51.18792  ? 114 LEU A CD1 1 
ATOM   151  C  CD2 . LEU A 1 21  ? 7.94541   35.49390  -22.84522 1.000 54.78985  ? 114 LEU A CD2 1 
ATOM   152  N  N   . HIS A 1 22  ? 6.69949   35.30512  -27.56630 1.000 51.02288  ? 115 HIS A N   1 
ATOM   153  C  CA  . HIS A 1 22  ? 6.61912   35.40525  -29.02598 1.000 60.28805  ? 115 HIS A CA  1 
ATOM   154  C  C   . HIS A 1 22  ? 7.67097   34.50581  -29.67149 1.000 57.26434  ? 115 HIS A C   1 
ATOM   155  O  O   . HIS A 1 22  ? 8.83821   34.52935  -29.26945 1.000 67.27369  ? 115 HIS A O   1 
ATOM   156  C  CB  . HIS A 1 22  ? 6.81330   36.86906  -29.46709 1.000 66.35511  ? 115 HIS A CB  1 
ATOM   157  C  CG  . HIS A 1 22  ? 6.66392   37.09685  -30.94678 1.000 74.37359  ? 115 HIS A CG  1 
ATOM   158  N  ND1 . HIS A 1 22  ? 7.74403   37.19148  -31.80188 1.000 72.64801  ? 115 HIS A ND1 1 
ATOM   159  C  CD2 . HIS A 1 22  ? 5.56043   37.26425  -31.71931 1.000 73.78135  ? 115 HIS A CD2 1 
ATOM   160  C  CE1 . HIS A 1 22  ? 7.31187   37.38876  -33.03742 1.000 73.89572  ? 115 HIS A CE1 1 
ATOM   161  N  NE2 . HIS A 1 22  ? 5.99088   37.43710  -33.01521 1.000 74.87869  ? 115 HIS A NE2 1 
ATOM   162  N  N   . SER A 1 23  ? 7.26587   33.71280  -30.67634 1.000 66.05328  ? 116 SER A N   1 
ATOM   163  C  CA  . SER A 1 23  ? 8.17150   32.71352  -31.25972 1.000 68.35614  ? 116 SER A CA  1 
ATOM   164  C  C   . SER A 1 23  ? 8.34047   32.78546  -32.77837 1.000 74.26518  ? 116 SER A C   1 
ATOM   165  O  O   . SER A 1 23  ? 9.40684   32.43182  -33.29433 1.000 73.31795  ? 116 SER A O   1 
ATOM   166  C  CB  . SER A 1 23  ? 7.71336   31.29997  -30.89298 1.000 64.53633  ? 116 SER A CB  1 
ATOM   167  N  N   . GLY A 1 24  ? 7.30701   33.19905  -33.51234 1.000 72.98733  ? 117 GLY A N   1 
ATOM   168  C  CA  . GLY A 1 24  ? 7.40182   33.37214  -34.94792 1.000 65.53572  ? 117 GLY A CA  1 
ATOM   169  C  C   . GLY A 1 24  ? 6.87239   32.17381  -35.72653 1.000 73.33410  ? 117 GLY A C   1 
ATOM   170  O  O   . GLY A 1 24  ? 6.51690   31.13198  -35.17155 1.000 72.55935  ? 117 GLY A O   1 
ATOM   171  N  N   . THR A 1 25  ? 6.83779   32.33855  -37.05400 1.000 69.12027  ? 118 THR A N   1 
ATOM   172  C  CA  . THR A 1 25  ? 6.32105   31.32529  -37.97027 1.000 71.75947  ? 118 THR A CA  1 
ATOM   173  C  C   . THR A 1 25  ? 7.38198   30.84413  -38.96226 1.000 73.91214  ? 118 THR A C   1 
ATOM   174  O  O   . THR A 1 25  ? 7.05412   30.47429  -40.09127 1.000 82.02322  ? 118 THR A O   1 
ATOM   175  C  CB  . THR A 1 25  ? 5.09550   31.84980  -38.72453 1.000 68.50485  ? 118 THR A CB  1 
ATOM   176  O  OG1 . THR A 1 25  ? 5.22812   33.25822  -38.95760 1.000 81.02116  ? 118 THR A OG1 1 
ATOM   177  C  CG2 . THR A 1 25  ? 3.83402   31.60088  -37.92603 1.000 65.89229  ? 118 THR A CG2 1 
ATOM   178  N  N   . ALA A 1 26  ? 8.65317   30.82613  -38.55606 1.000 76.63902  ? 119 ALA A N   1 
ATOM   179  C  CA  . ALA A 1 26  ? 9.73720   30.44754  -39.45796 1.000 76.09108  ? 119 ALA A CA  1 
ATOM   180  C  C   . ALA A 1 26  ? 9.66987   28.95548  -39.79154 1.000 76.14747  ? 119 ALA A C   1 
ATOM   181  O  O   . ALA A 1 26  ? 8.86121   28.20137  -39.24349 1.000 76.21963  ? 119 ALA A O   1 
ATOM   182  C  CB  . ALA A 1 26  ? 11.09437  30.79698  -38.84411 1.000 64.63499  ? 119 ALA A CB  1 
ATOM   183  N  N   . LYS A 1 27  ? 10.52312  28.52768  -40.72697 1.000 81.89732  ? 120 LYS A N   1 
ATOM   184  C  CA  . LYS A 1 27  ? 10.56829  27.10566  -41.06753 1.000 82.25568  ? 120 LYS A CA  1 
ATOM   185  C  C   . LYS A 1 27  ? 11.17180  26.28596  -39.93184 1.000 79.69677  ? 120 LYS A C   1 
ATOM   186  O  O   . LYS A 1 27  ? 10.66497  25.20847  -39.59419 1.000 81.24961  ? 120 LYS A O   1 
ATOM   187  C  CB  . LYS A 1 27  ? 11.35674  26.89563  -42.36002 1.000 76.25320  ? 120 LYS A CB  1 
ATOM   188  N  N   . SER A 1 28  ? 12.23405  26.80204  -39.31137 1.000 74.93746  ? 121 SER A N   1 
ATOM   189  C  CA  . SER A 1 28  ? 12.97073  26.09714  -38.27010 1.000 77.85744  ? 121 SER A CA  1 
ATOM   190  C  C   . SER A 1 28  ? 12.22899  25.99489  -36.93777 1.000 79.91836  ? 121 SER A C   1 
ATOM   191  O  O   . SER A 1 28  ? 12.70780  25.26978  -36.05759 1.000 82.03017  ? 121 SER A O   1 
ATOM   192  C  CB  . SER A 1 28  ? 14.31741  26.78974  -38.03977 1.000 79.43771  ? 121 SER A CB  1 
ATOM   193  O  OG  . SER A 1 28  ? 14.21486  27.79978  -37.04794 1.000 82.60741  ? 121 SER A OG  1 
ATOM   194  N  N   . VAL A 1 29  ? 11.10360  26.69990  -36.75509 1.000 71.26834  ? 122 VAL A N   1 
ATOM   195  C  CA  . VAL A 1 29  ? 10.46250  26.75976  -35.44251 1.000 65.50365  ? 122 VAL A CA  1 
ATOM   196  C  C   . VAL A 1 29  ? 9.98210   25.37224  -35.03447 1.000 61.17738  ? 122 VAL A C   1 
ATOM   197  O  O   . VAL A 1 29  ? 9.44692   24.61317  -35.85307 1.000 71.81986  ? 122 VAL A O   1 
ATOM   198  C  CB  . VAL A 1 29  ? 9.32245   27.79649  -35.44594 1.000 60.21788  ? 122 VAL A CB  1 
ATOM   199  C  CG1 . VAL A 1 29  ? 8.08831   27.31278  -36.21880 1.000 58.70255  ? 122 VAL A CG1 1 
ATOM   200  C  CG2 . VAL A 1 29  ? 8.93986   28.17412  -34.02432 1.000 58.94978  ? 122 VAL A CG2 1 
ATOM   201  N  N   . THR A 1 30  ? 10.24731  24.99548  -33.78062 1.000 52.06004  ? 123 THR A N   1 
ATOM   202  C  CA  . THR A 1 30  ? 9.74411   23.72127  -33.27599 1.000 64.82722  ? 123 THR A CA  1 
ATOM   203  C  C   . THR A 1 30  ? 8.43540   23.87529  -32.52067 1.000 62.16790  ? 123 THR A C   1 
ATOM   204  O  O   . THR A 1 30  ? 7.75201   22.87449  -32.27989 1.000 57.70453  ? 123 THR A O   1 
ATOM   205  C  CB  . THR A 1 30  ? 10.76368  23.03601  -32.35084 1.000 57.53091  ? 123 THR A CB  1 
ATOM   206  O  OG1 . THR A 1 30  ? 10.97973  23.83290  -31.17737 1.000 55.49467  ? 123 THR A OG1 1 
ATOM   207  C  CG2 . THR A 1 30  ? 12.08109  22.80711  -33.07106 1.000 57.76134  ? 123 THR A CG2 1 
ATOM   208  N  N   . CYS A 1 31  ? 8.06386   25.10505  -32.17532 1.000 60.72829  ? 124 CYS A N   1 
ATOM   209  C  CA  . CYS A 1 31  ? 6.97349   25.36161  -31.24268 1.000 47.22865  ? 124 CYS A CA  1 
ATOM   210  C  C   . CYS A 1 31  ? 6.55234   26.81426  -31.40231 1.000 48.75503  ? 124 CYS A C   1 
ATOM   211  O  O   . CYS A 1 31  ? 7.38022   27.70989  -31.22365 1.000 55.02300  ? 124 CYS A O   1 
ATOM   212  C  CB  . CYS A 1 31  ? 7.44245   25.08175  -29.82418 1.000 45.74204  ? 124 CYS A CB  1 
ATOM   213  S  SG  . CYS A 1 31  ? 6.23475   25.47752  -28.57892 1.000 60.72512  ? 124 CYS A SG  1 
ATOM   214  N  N   . THR A 1 32  ? 5.28704   27.06029  -31.73767 1.000 44.12515  ? 125 THR A N   1 
ATOM   215  C  CA  . THR A 1 32  ? 4.82793   28.43215  -31.91359 1.000 45.74839  ? 125 THR A CA  1 
ATOM   216  C  C   . THR A 1 32  ? 3.37026   28.54580  -31.48371 1.000 44.13659  ? 125 THR A C   1 
ATOM   217  O  O   . THR A 1 32  ? 2.55468   27.66310  -31.76735 1.000 41.89637  ? 125 THR A O   1 
ATOM   218  C  CB  . THR A 1 32  ? 5.01742   28.91252  -33.37041 1.000 47.65019  ? 125 THR A CB  1 
ATOM   219  O  OG1 . THR A 1 32  ? 4.57907   30.27892  -33.49982 1.000 51.80366  ? 125 THR A OG1 1 
ATOM   220  C  CG2 . THR A 1 32  ? 4.25554   28.05576  -34.34931 1.000 44.99923  ? 125 THR A CG2 1 
ATOM   221  N  N   . TYR A 1 33  ? 3.05910   29.63794  -30.79237 1.000 38.08395  ? 126 TYR A N   1 
ATOM   222  C  CA  . TYR A 1 33  ? 1.73547   29.90726  -30.23823 1.000 38.51204  ? 126 TYR A CA  1 
ATOM   223  C  C   . TYR A 1 33  ? 1.04147   31.01653  -31.02231 1.000 41.81426  ? 126 TYR A C   1 
ATOM   224  O  O   . TYR A 1 33  ? 1.63674   32.07146  -31.26971 1.000 44.75647  ? 126 TYR A O   1 
ATOM   225  C  CB  . TYR A 1 33  ? 1.83482   30.31873  -28.76651 1.000 39.13588  ? 126 TYR A CB  1 
ATOM   226  C  CG  . TYR A 1 33  ? 0.51660   30.74410  -28.16923 1.000 41.32731  ? 126 TYR A CG  1 
ATOM   227  C  CD1 . TYR A 1 33  ? -0.46864  29.79937  -27.85836 1.000 39.51415  ? 126 TYR A CD1 1 
ATOM   228  C  CD2 . TYR A 1 33  ? 0.24925   32.08279  -27.91623 1.000 37.54047  ? 126 TYR A CD2 1 
ATOM   229  C  CE1 . TYR A 1 33  ? -1.68375  30.18116  -27.31268 1.000 41.03578  ? 126 TYR A CE1 1 
ATOM   230  C  CE2 . TYR A 1 33  ? -0.95863  32.47331  -27.37275 1.000 39.43629  ? 126 TYR A CE2 1 
ATOM   231  C  CZ  . TYR A 1 33  ? -1.92511  31.52471  -27.07502 1.000 37.04511  ? 126 TYR A CZ  1 
ATOM   232  O  OH  . TYR A 1 33  ? -3.12894  31.92841  -26.52447 1.000 37.87252  ? 126 TYR A OH  1 
ATOM   233  N  N   . SER A 1 34  ? -0.22668  30.78927  -31.37261 1.000 39.27846  ? 127 SER A N   1 
ATOM   234  C  CA  . SER A 1 34  ? -1.03564  31.75746  -32.09822 1.000 39.43719  ? 127 SER A CA  1 
ATOM   235  C  C   . SER A 1 34  ? -2.06867  32.37476  -31.17070 1.000 46.63537  ? 127 SER A C   1 
ATOM   236  O  O   . SER A 1 34  ? -3.04700  31.70015  -30.81035 1.000 34.21755  ? 127 SER A O   1 
ATOM   237  C  CB  . SER A 1 34  ? -1.72523  31.10723  -33.29699 1.000 45.35358  ? 127 SER A CB  1 
ATOM   238  O  OG  . SER A 1 34  ? -2.80755  31.90187  -33.76162 1.000 44.91955  ? 127 SER A OG  1 
ATOM   239  N  N   . PRO A 1 35  ? -1.89003  33.64060  -30.75990 1.000 34.69110  ? 128 PRO A N   1 
ATOM   240  C  CA  . PRO A 1 35  ? -2.91539  34.31163  -29.93638 1.000 41.40619  ? 128 PRO A CA  1 
ATOM   241  C  C   . PRO A 1 35  ? -4.28861  34.35112  -30.58221 1.000 43.32074  ? 128 PRO A C   1 
ATOM   242  O  O   . PRO A 1 35  ? -5.29960  34.14047  -29.90066 1.000 46.38802  ? 128 PRO A O   1 
ATOM   243  C  CB  . PRO A 1 35  ? -2.36250  35.74625  -29.78722 1.000 41.30607  ? 128 PRO A CB  1 
ATOM   244  C  CG  . PRO A 1 35  ? -0.89757  35.63307  -29.98816 1.000 42.40986  ? 128 PRO A CG  1 
ATOM   245  C  CD  . PRO A 1 35  ? -0.67084  34.45627  -30.92257 1.000 45.05229  ? 128 PRO A CD  1 
ATOM   246  N  N   . ALA A 1 36  ? -4.34842  34.61802  -31.88933 1.000 48.89584  ? 129 ALA A N   1 
ATOM   247  C  CA  . ALA A 1 36  ? -5.63619  34.78149  -32.54692 1.000 52.89450  ? 129 ALA A CA  1 
ATOM   248  C  C   . ALA A 1 36  ? -6.42875  33.48224  -32.53709 1.000 45.19825  ? 129 ALA A C   1 
ATOM   249  O  O   . ALA A 1 36  ? -7.66109  33.50632  -32.44411 1.000 49.80331  ? 129 ALA A O   1 
ATOM   250  C  CB  . ALA A 1 36  ? -5.43084  35.29908  -33.97302 1.000 43.08328  ? 129 ALA A CB  1 
ATOM   251  N  N   . LEU A 1 37  ? -5.74739  32.34944  -32.59070 1.000 46.98347  ? 130 LEU A N   1 
ATOM   252  C  CA  . LEU A 1 37  ? -6.41865  31.06297  -32.47273 1.000 46.39310  ? 130 LEU A CA  1 
ATOM   253  C  C   . LEU A 1 37  ? -6.43900  30.51175  -31.04570 1.000 45.48216  ? 130 LEU A C   1 
ATOM   254  O  O   . LEU A 1 37  ? -7.21841  29.59475  -30.78335 1.000 48.15500  ? 130 LEU A O   1 
ATOM   255  C  CB  . LEU A 1 37  ? -5.76044  30.04547  -33.42139 1.000 39.66701  ? 130 LEU A CB  1 
ATOM   256  C  CG  . LEU A 1 37  ? -5.70873  30.43950  -34.90749 1.000 41.75358  ? 130 LEU A CG  1 
ATOM   257  C  CD1 . LEU A 1 37  ? -4.69812  29.62550  -35.71103 1.000 40.73295  ? 130 LEU A CD1 1 
ATOM   258  C  CD2 . LEU A 1 37  ? -7.07859  30.31810  -35.52363 1.000 43.44974  ? 130 LEU A CD2 1 
ATOM   259  N  N   . ASN A 1 38  ? -5.64398  31.06422  -30.11762 1.000 43.08365  ? 131 ASN A N   1 
ATOM   260  C  CA  . ASN A 1 38  ? -5.36279  30.43049  -28.81547 1.000 42.00373  ? 131 ASN A CA  1 
ATOM   261  C  C   . ASN A 1 38  ? -4.93467  28.98026  -29.02425 1.000 47.28806  ? 131 ASN A C   1 
ATOM   262  O  O   . ASN A 1 38  ? -5.43871  28.04949  -28.39066 1.000 46.25513  ? 131 ASN A O   1 
ATOM   263  C  CB  . ASN A 1 38  ? -6.55757  30.53265  -27.86234 1.000 35.36611  ? 131 ASN A CB  1 
ATOM   264  C  CG  . ASN A 1 38  ? -6.25391  30.01465  -26.45565 1.000 37.81077  ? 131 ASN A CG  1 
ATOM   265  O  OD1 . ASN A 1 38  ? -5.12963  30.09555  -25.95210 1.000 36.92641  ? 131 ASN A OD1 1 
ATOM   266  N  ND2 . ASN A 1 38  ? -7.26985  29.46804  -25.82370 1.000 37.31309  ? 131 ASN A ND2 1 
ATOM   267  N  N   . LYS A 1 39  ? -4.01682  28.78703  -29.97243 1.000 37.97453  ? 132 LYS A N   1 
ATOM   268  C  CA  . LYS A 1 39  ? -3.60225  27.45321  -30.37948 1.000 41.28418  ? 132 LYS A CA  1 
ATOM   269  C  C   . LYS A 1 39  ? -2.08432  27.37467  -30.36149 1.000 42.78487  ? 132 LYS A C   1 
ATOM   270  O  O   . LYS A 1 39  ? -1.40049  28.26422  -30.88219 1.000 39.88076  ? 132 LYS A O   1 
ATOM   271  C  CB  . LYS A 1 39  ? -4.12806  27.11342  -31.77523 1.000 43.20779  ? 132 LYS A CB  1 
ATOM   272  C  CG  . LYS A 1 39  ? -4.06469  25.61785  -32.16741 1.000 46.49444  ? 132 LYS A CG  1 
ATOM   273  C  CD  . LYS A 1 39  ? -4.97495  25.41502  -33.36819 1.000 51.36953  ? 132 LYS A CD  1 
ATOM   274  C  CE  . LYS A 1 39  ? -4.78038  24.10303  -34.09600 1.000 51.59666  ? 132 LYS A CE  1 
ATOM   275  N  NZ  . LYS A 1 39  ? -5.99786  23.84376  -34.92863 1.000 46.41472  ? 132 LYS A NZ  1 
ATOM   276  N  N   . LEU A 1 40  ? -1.56302  26.31294  -29.77242 1.000 35.95053  ? 133 LEU A N   1 
ATOM   277  C  CA  . LEU A 1 40  ? -0.13617  26.04852  -29.77951 1.000 37.38203  ? 133 LEU A CA  1 
ATOM   278  C  C   . LEU A 1 40  ? 0.18825   25.05551  -30.88575 1.000 41.33379  ? 133 LEU A C   1 
ATOM   279  O  O   . LEU A 1 40  ? -0.48314  24.03166  -31.02470 1.000 43.50744  ? 133 LEU A O   1 
ATOM   280  C  CB  . LEU A 1 40  ? 0.31482   25.50914  -28.42594 1.000 35.13538  ? 133 LEU A CB  1 
ATOM   281  C  CG  . LEU A 1 40  ? 1.77615   25.07341  -28.40589 1.000 44.25067  ? 133 LEU A CG  1 
ATOM   282  C  CD1 . LEU A 1 40  ? 2.69044   26.29426  -28.55171 1.000 43.66588  ? 133 LEU A CD1 1 
ATOM   283  C  CD2 . LEU A 1 40  ? 2.05808   24.33200  -27.12835 1.000 42.33266  ? 133 LEU A CD2 1 
ATOM   284  N  N   . PHE A 1 41  ? 1.20469   25.36181  -31.67734 1.000 38.28615  ? 134 PHE A N   1 
ATOM   285  C  CA  . PHE A 1 41  ? 1.63010   24.49767  -32.76974 1.000 47.00534  ? 134 PHE A CA  1 
ATOM   286  C  C   . PHE A 1 41  ? 3.01631   23.98149  -32.44578 1.000 46.47076  ? 134 PHE A C   1 
ATOM   287  O  O   . PHE A 1 41  ? 3.91567   24.77743  -32.16506 1.000 45.25783  ? 134 PHE A O   1 
ATOM   288  C  CB  . PHE A 1 41  ? 1.65199   25.25040  -34.10657 1.000 49.84387  ? 134 PHE A CB  1 
ATOM   289  C  CG  . PHE A 1 41  ? 0.29957   25.68366  -34.57685 1.000 50.13298  ? 134 PHE A CG  1 
ATOM   290  C  CD1 . PHE A 1 41  ? -0.27789  26.83681  -34.09130 1.000 38.77329  ? 134 PHE A CD1 1 
ATOM   291  C  CD2 . PHE A 1 41  ? -0.40441  24.92018  -35.50170 1.000 51.89945  ? 134 PHE A CD2 1 
ATOM   292  C  CE1 . PHE A 1 41  ? -1.52858  27.22560  -34.51871 1.000 48.49848  ? 134 PHE A CE1 1 
ATOM   293  C  CE2 . PHE A 1 41  ? -1.65512  25.31452  -35.93798 1.000 48.76471  ? 134 PHE A CE2 1 
ATOM   294  C  CZ  . PHE A 1 41  ? -2.21955  26.45477  -35.44778 1.000 41.34073  ? 134 PHE A CZ  1 
ATOM   295  N  N   . CYS A 1 42  ? 3.19950   22.66412  -32.49435 1.000 46.11546  ? 135 CYS A N   1 
ATOM   296  C  CA  . CYS A 1 42  ? 4.46738   22.13761  -32.02942 1.000 40.71708  ? 135 CYS A CA  1 
ATOM   297  C  C   . CYS A 1 42  ? 4.81725   20.84029  -32.73816 1.000 47.56314  ? 135 CYS A C   1 
ATOM   298  O  O   . CYS A 1 42  ? 3.96723   20.15439  -33.31571 1.000 39.18272  ? 135 CYS A O   1 
ATOM   299  C  CB  . CYS A 1 42  ? 4.43825   21.89960  -30.51899 1.000 40.05390  ? 135 CYS A CB  1 
ATOM   300  S  SG  . CYS A 1 42  ? 3.19746   20.70247  -30.02337 1.000 46.59584  ? 135 CYS A SG  1 
ATOM   301  N  N   . GLN A 1 43  ? 6.09487   20.51397  -32.66402 1.000 42.54519  ? 136 GLN A N   1 
ATOM   302  C  CA  . GLN A 1 43  ? 6.62955   19.28837  -33.20974 1.000 49.07904  ? 136 GLN A CA  1 
ATOM   303  C  C   . GLN A 1 43  ? 6.58085   18.19744  -32.15321 1.000 51.57705  ? 136 GLN A C   1 
ATOM   304  O  O   . GLN A 1 43  ? 6.44028   18.45774  -30.95540 1.000 53.24480  ? 136 GLN A O   1 
ATOM   305  C  CB  . GLN A 1 43  ? 8.05692   19.51183  -33.69581 1.000 50.53570  ? 136 GLN A CB  1 
ATOM   306  C  CG  . GLN A 1 43  ? 8.12363   19.74553  -35.18541 1.000 56.23633  ? 136 GLN A CG  1 
ATOM   307  C  CD  . GLN A 1 43  ? 9.40796   20.40119  -35.62335 1.000 61.97529  ? 136 GLN A CD  1 
ATOM   308  O  OE1 . GLN A 1 43  ? 10.46652  20.19360  -35.02851 1.000 62.98772  ? 136 GLN A OE1 1 
ATOM   309  N  NE2 . GLN A 1 43  ? 9.32087   21.21268  -36.67096 1.000 66.71485  ? 136 GLN A NE2 1 
ATOM   310  N  N   . LEU A 1 44  ? 6.67558   16.96168  -32.61394 1.000 54.80177  ? 137 LEU A N   1 
ATOM   311  C  CA  . LEU A 1 44  ? 6.59720   15.83393  -31.70398 1.000 43.08970  ? 137 LEU A CA  1 
ATOM   312  C  C   . LEU A 1 44  ? 7.83811   15.77078  -30.82407 1.000 46.62389  ? 137 LEU A C   1 
ATOM   313  O  O   . LEU A 1 44  ? 8.96541   15.86785  -31.31880 1.000 55.92471  ? 137 LEU A O   1 
ATOM   314  C  CB  . LEU A 1 44  ? 6.43601   14.53909  -32.49636 1.000 47.55982  ? 137 LEU A CB  1 
ATOM   315  C  CG  . LEU A 1 44  ? 5.89429   13.38835  -31.65045 1.000 46.89057  ? 137 LEU A CG  1 
ATOM   316  C  CD1 . LEU A 1 44  ? 4.89908   12.59851  -32.44817 1.000 55.39245  ? 137 LEU A CD1 1 
ATOM   317  C  CD2 . LEU A 1 44  ? 7.02630   12.50743  -31.20699 1.000 52.41188  ? 137 LEU A CD2 1 
ATOM   318  N  N   . ALA A 1 45  ? 7.61734   15.60252  -29.51701 1.000 38.28785  ? 138 ALA A N   1 
ATOM   319  C  CA  . ALA A 1 45  ? 8.67597   15.40967  -28.52257 1.000 42.46429  ? 138 ALA A CA  1 
ATOM   320  C  C   . ALA A 1 45  ? 9.62792   16.60066  -28.42965 1.000 47.18843  ? 138 ALA A C   1 
ATOM   321  O  O   . ALA A 1 45  ? 10.78822  16.44772  -28.04216 1.000 60.68324  ? 138 ALA A O   1 
ATOM   322  C  CB  . ALA A 1 45  ? 9.46380   14.11761  -28.78238 1.000 47.09995  ? 138 ALA A CB  1 
ATOM   323  N  N   . LYS A 1 46  ? 9.15252   17.79947  -28.74634 1.000 51.95431  ? 139 LYS A N   1 
ATOM   324  C  CA  . LYS A 1 46  ? 9.96210   19.00760  -28.67447 1.000 45.85404  ? 139 LYS A CA  1 
ATOM   325  C  C   . LYS A 1 46  ? 9.46470   19.91164  -27.54938 1.000 49.19097  ? 139 LYS A C   1 
ATOM   326  O  O   . LYS A 1 46  ? 8.26199   19.96173  -27.26357 1.000 44.07891  ? 139 LYS A O   1 
ATOM   327  C  CB  . LYS A 1 46  ? 9.91956   19.76192  -30.00415 1.000 49.17247  ? 139 LYS A CB  1 
ATOM   328  C  CG  . LYS A 1 46  ? 10.69826  19.11663  -31.14067 1.000 59.08331  ? 139 LYS A CG  1 
ATOM   329  C  CD  . LYS A 1 46  ? 12.09338  18.68596  -30.71835 1.000 61.31615  ? 139 LYS A CD  1 
ATOM   330  C  CE  . LYS A 1 46  ? 12.87450  18.14749  -31.91074 1.000 57.62636  ? 139 LYS A CE  1 
ATOM   331  N  N   . THR A 1 47  ? 10.40371  20.64897  -26.93809 1.000 43.33953  ? 140 THR A N   1 
ATOM   332  C  CA  . THR A 1 47  ? 10.10597  21.50432  -25.78980 1.000 47.63759  ? 140 THR A CA  1 
ATOM   333  C  C   . THR A 1 47  ? 9.04084   22.54390  -26.12422 1.000 45.67590  ? 140 THR A C   1 
ATOM   334  O  O   . THR A 1 47  ? 9.11523   23.22035  -27.15282 1.000 48.40716  ? 140 THR A O   1 
ATOM   335  C  CB  . THR A 1 47  ? 11.37223  22.22508  -25.31324 1.000 45.74047  ? 140 THR A CB  1 
ATOM   336  O  OG1 . THR A 1 47  ? 12.43001  21.28647  -25.13441 1.000 53.27694  ? 140 THR A OG1 1 
ATOM   337  C  CG2 . THR A 1 47  ? 11.12784  22.89150  -23.99429 1.000 42.87220  ? 140 THR A CG2 1 
ATOM   338  N  N   . CYS A 1 48  ? 8.04794   22.66492  -25.24395 1.000 41.66764  ? 141 CYS A N   1 
ATOM   339  C  CA  . CYS A 1 48  ? 6.99193   23.67091  -25.35635 1.000 40.04729  ? 141 CYS A CA  1 
ATOM   340  C  C   . CYS A 1 48  ? 6.97495   24.47443  -24.07545 1.000 44.38506  ? 141 CYS A C   1 
ATOM   341  O  O   . CYS A 1 48  ? 6.44209   24.00396  -23.05417 1.000 43.62323  ? 141 CYS A O   1 
ATOM   342  C  CB  . CYS A 1 48  ? 5.63053   23.03490  -25.59733 1.000 50.29847  ? 141 CYS A CB  1 
ATOM   343  S  SG  . CYS A 1 48  ? 5.49813   22.10187  -27.11960 1.000 49.31385  ? 141 CYS A SG  1 
ATOM   344  N  N   . PRO A 1 49  ? 7.54667   25.68045  -24.05792 1.000 39.20328  ? 142 PRO A N   1 
ATOM   345  C  CA  . PRO A 1 49  ? 7.55727   26.48635  -22.83221 1.000 44.07690  ? 142 PRO A CA  1 
ATOM   346  C  C   . PRO A 1 49  ? 6.21903   27.18444  -22.62691 1.000 39.24693  ? 142 PRO A C   1 
ATOM   347  O  O   . PRO A 1 49  ? 5.77968   27.97255  -23.46537 1.000 43.13363  ? 142 PRO A O   1 
ATOM   348  C  CB  . PRO A 1 49  ? 8.69055   27.49191  -23.07950 1.000 44.29307  ? 142 PRO A CB  1 
ATOM   349  C  CG  . PRO A 1 49  ? 8.79601   27.59859  -24.57468 1.000 42.51103  ? 142 PRO A CG  1 
ATOM   350  C  CD  . PRO A 1 49  ? 8.21503   26.34735  -25.18808 1.000 39.72433  ? 142 PRO A CD  1 
ATOM   351  N  N   . VAL A 1 50  ? 5.57684   26.89949  -21.49961 1.000 32.95378  ? 143 VAL A N   1 
ATOM   352  C  CA  . VAL A 1 50  ? 4.35632   27.57507  -21.08035 1.000 37.73212  ? 143 VAL A CA  1 
ATOM   353  C  C   . VAL A 1 50  ? 4.68824   28.39134  -19.84941 1.000 41.01775  ? 143 VAL A C   1 
ATOM   354  O  O   . VAL A 1 50  ? 5.23078   27.85813  -18.87520 1.000 40.18516  ? 143 VAL A O   1 
ATOM   355  C  CB  . VAL A 1 50  ? 3.21655   26.59158  -20.77316 1.000 36.28543  ? 143 VAL A CB  1 
ATOM   356  C  CG1 . VAL A 1 50  ? 1.94562   27.35789  -20.44012 1.000 35.37780  ? 143 VAL A CG1 1 
ATOM   357  C  CG2 . VAL A 1 50  ? 2.99929   25.65569  -21.93954 1.000 33.82272  ? 143 VAL A CG2 1 
ATOM   358  N  N   A GLN A 1 51  ? 4.37279   29.68125  -19.89750 0.500 40.68362  ? 144 GLN A N   1 
ATOM   359  N  N   B GLN A 1 51  ? 4.37624   29.68536  -19.89668 0.500 40.68341  ? 144 GLN A N   1 
ATOM   360  C  CA  A GLN A 1 51  ? 4.61062   30.57935  -18.78050 0.500 40.77913  ? 144 GLN A CA  1 
ATOM   361  C  CA  B GLN A 1 51  ? 4.62065   30.58766  -18.78302 0.500 40.79407  ? 144 GLN A CA  1 
ATOM   362  C  C   A GLN A 1 51  ? 3.39177   30.61459  -17.87259 0.500 40.61503  ? 144 GLN A C   1 
ATOM   363  C  C   B GLN A 1 51  ? 3.39923   30.62521  -17.87477 0.500 40.61713  ? 144 GLN A C   1 
ATOM   364  O  O   A GLN A 1 51  ? 2.25226   30.69771  -18.34382 0.500 40.34856  ? 144 GLN A O   1 
ATOM   365  O  O   B GLN A 1 51  ? 2.26338   30.72150  -18.35322 0.500 40.35514  ? 144 GLN A O   1 
ATOM   366  C  CB  A GLN A 1 51  ? 4.91867   31.98994  -19.28053 0.500 41.62448  ? 144 GLN A CB  1 
ATOM   367  C  CB  B GLN A 1 51  ? 4.94403   31.99817  -19.28414 0.500 41.62764  ? 144 GLN A CB  1 
ATOM   368  C  CG  A GLN A 1 51  ? 6.18987   32.10062  -20.09270 0.500 44.47468  ? 144 GLN A CG  1 
ATOM   369  C  CG  B GLN A 1 51  ? 5.77747   32.04687  -20.55929 0.500 43.58133  ? 144 GLN A CG  1 
ATOM   370  C  CD  A GLN A 1 51  ? 6.73128   33.51090  -20.09873 0.500 50.57452  ? 144 GLN A CD  1 
ATOM   371  C  CD  B GLN A 1 51  ? 7.19708   31.55370  -20.34598 0.500 45.89526  ? 144 GLN A CD  1 
ATOM   372  O  OE1 A GLN A 1 51  ? 5.98265   34.46904  -20.28193 0.500 45.33202  ? 144 GLN A OE1 1 
ATOM   373  O  OE1 B GLN A 1 51  ? 7.76503   31.71411  -19.26158 0.500 45.34527  ? 144 GLN A OE1 1 
ATOM   374  N  NE2 A GLN A 1 51  ? 8.03525   33.64852  -19.87925 0.500 57.34658  ? 144 GLN A NE2 1 
ATOM   375  N  NE2 B GLN A 1 51  ? 7.77767   30.94551  -21.37876 0.500 40.61451  ? 144 GLN A NE2 1 
ATOM   376  N  N   . LEU A 1 52  ? 3.63742   30.54790  -16.56905 1.000 35.17362  ? 145 LEU A N   1 
ATOM   377  C  CA  . LEU A 1 52  ? 2.58965   30.64468  -15.56134 1.000 36.47302  ? 145 LEU A CA  1 
ATOM   378  C  C   . LEU A 1 52  ? 2.65598   32.01812  -14.89641 1.000 45.41993  ? 145 LEU A C   1 
ATOM   379  O  O   . LEU A 1 52  ? 3.74190   32.48657  -14.53558 1.000 44.17399  ? 145 LEU A O   1 
ATOM   380  C  CB  . LEU A 1 52  ? 2.74430   29.54607  -14.51351 1.000 44.97720  ? 145 LEU A CB  1 
ATOM   381  C  CG  . LEU A 1 52  ? 2.80475   28.10206  -15.02047 1.000 46.51682  ? 145 LEU A CG  1 
ATOM   382  C  CD1 . LEU A 1 52  ? 2.73900   27.16611  -13.84432 1.000 51.14576  ? 145 LEU A CD1 1 
ATOM   383  C  CD2 . LEU A 1 52  ? 1.66226   27.83475  -15.94884 1.000 41.63963  ? 145 LEU A CD2 1 
ATOM   384  N  N   . TRP A 1 53  ? 1.50729   32.66936  -14.74638 1.000 34.83516  ? 146 TRP A N   1 
ATOM   385  C  CA  . TRP A 1 53  ? 1.43902   33.92571  -14.01226 1.000 37.48353  ? 146 TRP A CA  1 
ATOM   386  C  C   . TRP A 1 53  ? 0.42816   33.82704  -12.87608 1.000 33.96804  ? 146 TRP A C   1 
ATOM   387  O  O   . TRP A 1 53  ? -0.67223  33.29729  -13.05756 1.000 41.33828  ? 146 TRP A O   1 
ATOM   388  C  CB  . TRP A 1 53  ? 1.07003   35.08823  -14.94510 0.500 32.74828  ? 146 TRP A CB  1 
ATOM   389  N  N   . VAL A 1 54  ? 0.80942   34.34342  -11.70088 1.000 37.06051  ? 147 VAL A N   1 
ATOM   390  C  CA  . VAL A 1 54  ? -0.11048  34.58995  -10.59188 1.000 38.42178  ? 147 VAL A CA  1 
ATOM   391  C  C   . VAL A 1 54  ? 0.07532   36.01572  -10.08464 1.000 40.52657  ? 147 VAL A C   1 
ATOM   392  O  O   . VAL A 1 54  ? 1.19006   36.54834  -10.06467 1.000 38.10660  ? 147 VAL A O   1 
ATOM   393  C  CB  . VAL A 1 54  ? 0.08169   33.59810  -9.41622  1.000 38.32563  ? 147 VAL A CB  1 
ATOM   394  C  CG1 . VAL A 1 54  ? -0.36125  32.19337  -9.80138  1.000 38.28348  ? 147 VAL A CG1 1 
ATOM   395  C  CG2 . VAL A 1 54  ? 1.52462   33.59309  -8.92838  1.000 37.71836  ? 147 VAL A CG2 1 
ATOM   396  N  N   . ASP A 1 55  ? -1.03176  36.63177  -9.65384  1.000 39.63226  ? 148 ASP A N   1 
ATOM   397  C  CA  . ASP A 1 55  ? -0.94921  37.93226  -8.97713  1.000 45.10569  ? 148 ASP A CA  1 
ATOM   398  C  C   . ASP A 1 55  ? -0.30903  37.82601  -7.59452  1.000 52.25795  ? 148 ASP A C   1 
ATOM   399  O  O   . ASP A 1 55  ? 0.30503   38.78893  -7.13041  1.000 43.75683  ? 148 ASP A O   1 
ATOM   400  C  CB  . ASP A 1 55  ? -2.33630  38.56066  -8.82913  1.000 37.96768  ? 148 ASP A CB  1 
ATOM   401  C  CG  . ASP A 1 55  ? -2.97950  38.90126  -10.15992 1.000 50.71552  ? 148 ASP A CG  1 
ATOM   402  O  OD1 . ASP A 1 55  ? -2.25756  39.28993  -11.11097 1.000 50.57003  ? 148 ASP A OD1 1 
ATOM   403  O  OD2 . ASP A 1 55  ? -4.22387  38.79129  -10.24733 1.000 56.32119  ? 148 ASP A OD2 1 
ATOM   404  N  N   . SER A 1 56  ? -0.46453  36.69386  -6.90450  1.000 49.50685  ? 149 SER A N   1 
ATOM   405  C  CA  . SER A 1 56  ? 0.05798   36.56278  -5.54842  1.000 51.86909  ? 149 SER A CA  1 
ATOM   406  C  C   . SER A 1 56  ? 0.51141   35.12843  -5.32294  1.000 44.49062  ? 149 SER A C   1 
ATOM   407  O  O   . SER A 1 56  ? -0.00195  34.19844  -5.94839  1.000 52.63818  ? 149 SER A O   1 
ATOM   408  C  CB  . SER A 1 56  ? -0.97976  36.96477  -4.48650  1.000 58.96811  ? 149 SER A CB  1 
ATOM   409  O  OG  . SER A 1 56  ? -2.27887  36.49630  -4.80989  1.000 58.17693  ? 149 SER A OG  1 
ATOM   410  N  N   . THR A 1 57  ? 1.48076   34.95846  -4.42772  1.000 43.78595  ? 150 THR A N   1 
ATOM   411  C  CA  . THR A 1 57  ? 2.16248   33.67491  -4.30932  1.000 52.53934  ? 150 THR A CA  1 
ATOM   412  C  C   . THR A 1 57  ? 1.23328   32.63634  -3.68972  1.000 52.02313  ? 150 THR A C   1 
ATOM   413  O  O   . THR A 1 57  ? 0.58571   32.91629  -2.67454  1.000 49.17481  ? 150 THR A O   1 
ATOM   414  C  CB  . THR A 1 57  ? 3.43370   33.80086  -3.47325  1.000 56.94042  ? 150 THR A CB  1 
ATOM   415  O  OG1 . THR A 1 57  ? 4.33221   34.71239  -4.11604  1.000 57.48730  ? 150 THR A OG1 1 
ATOM   416  C  CG2 . THR A 1 57  ? 4.12621   32.43492  -3.35485  1.000 44.66417  ? 150 THR A CG2 1 
ATOM   417  N  N   . PRO A 1 58  ? 1.11374   31.45220  -4.28153  1.000 48.36689  ? 151 PRO A N   1 
ATOM   418  C  CA  . PRO A 1 58  ? 0.26713   30.40896  -3.70506  1.000 45.11455  ? 151 PRO A CA  1 
ATOM   419  C  C   . PRO A 1 58  ? 1.00895   29.63035  -2.62995  1.000 41.01241  ? 151 PRO A C   1 
ATOM   420  O  O   . PRO A 1 58  ? 2.24903   29.62837  -2.59330  1.000 39.51672  ? 151 PRO A O   1 
ATOM   421  C  CB  . PRO A 1 58  ? -0.06648  29.53404  -4.92552  1.000 42.29052  ? 151 PRO A CB  1 
ATOM   422  C  CG  . PRO A 1 58  ? 1.11735   29.67734  -5.79900  1.000 46.09658  ? 151 PRO A CG  1 
ATOM   423  C  CD  . PRO A 1 58  ? 1.62684   31.07524  -5.61167  1.000 44.22344  ? 151 PRO A CD  1 
ATOM   424  N  N   . PRO A 1 59  ? 0.28767   28.96447  -1.72990  1.000 39.94797  ? 152 PRO A N   1 
ATOM   425  C  CA  . PRO A 1 59  ? 0.92617   28.32752  -0.56751  1.000 43.32358  ? 152 PRO A CA  1 
ATOM   426  C  C   . PRO A 1 59  ? 1.85505   27.20305  -0.98539  1.000 42.68861  ? 152 PRO A C   1 
ATOM   427  O  O   . PRO A 1 59  ? 1.72271   26.66202  -2.08822  1.000 41.65380  ? 152 PRO A O   1 
ATOM   428  C  CB  . PRO A 1 59  ? -0.26808  27.78689  0.23590   1.000 41.63283  ? 152 PRO A CB  1 
ATOM   429  C  CG  . PRO A 1 59  ? -1.40280  28.66362  -0.16771  1.000 45.94910  ? 152 PRO A CG  1 
ATOM   430  C  CD  . PRO A 1 59  ? -1.17924  28.94334  -1.62167  1.000 46.46480  ? 152 PRO A CD  1 
ATOM   431  N  N   . PRO A 1 60  ? 2.83623   26.86648  -0.15126  1.000 43.24410  ? 153 PRO A N   1 
ATOM   432  C  CA  . PRO A 1 60  ? 3.70989   25.72860  -0.44774  1.000 44.09548  ? 153 PRO A CA  1 
ATOM   433  C  C   . PRO A 1 60  ? 2.90722   24.44639  -0.60762  1.000 42.66281  ? 153 PRO A C   1 
ATOM   434  O  O   . PRO A 1 60  ? 1.96216   24.18390  0.14034   1.000 37.04843  ? 153 PRO A O   1 
ATOM   435  C  CB  . PRO A 1 60  ? 4.62553   25.66669  0.78139   1.000 43.99898  ? 153 PRO A CB  1 
ATOM   436  C  CG  . PRO A 1 60  ? 4.62469   27.06398  1.31149   1.000 41.75356  ? 153 PRO A CG  1 
ATOM   437  C  CD  . PRO A 1 60  ? 3.23137   27.55730  1.08924   1.000 43.96079  ? 153 PRO A CD  1 
ATOM   438  N  N   . GLY A 1 61  ? 3.28878   23.65335  -1.60249  1.000 41.44473  ? 154 GLY A N   1 
ATOM   439  C  CA  . GLY A 1 61  ? 2.55767   22.45500  -1.95967  1.000 35.89448  ? 154 GLY A CA  1 
ATOM   440  C  C   . GLY A 1 61  ? 1.48089   22.65874  -2.99955  1.000 40.93198  ? 154 GLY A C   1 
ATOM   441  O  O   . GLY A 1 61  ? 0.74820   21.71003  -3.29670  1.000 42.88687  ? 154 GLY A O   1 
ATOM   442  N  N   . THR A 1 62  ? 1.32108   23.87574  -3.51956  1.000 38.29491  ? 155 THR A N   1 
ATOM   443  C  CA  . THR A 1 62  ? 0.47228   24.07652  -4.68509  1.000 38.86890  ? 155 THR A CA  1 
ATOM   444  C  C   . THR A 1 62  ? 1.07186   23.32080  -5.86948  1.000 36.13227  ? 155 THR A C   1 
ATOM   445  O  O   . THR A 1 62  ? 2.29444   23.27484  -6.03152  1.000 35.45325  ? 155 THR A O   1 
ATOM   446  C  CB  . THR A 1 62  ? 0.35958   25.57836  -4.98959  1.000 41.41908  ? 155 THR A CB  1 
ATOM   447  O  OG1 . THR A 1 62  ? -0.07248  26.27426  -3.81290  1.000 42.23562  ? 155 THR A OG1 1 
ATOM   448  C  CG2 . THR A 1 62  ? -0.63813  25.85213  -6.10694  1.000 38.45830  ? 155 THR A CG2 1 
ATOM   449  N  N   . ARG A 1 63  ? 0.22145   22.70193  -6.68992  1.000 34.10308  ? 156 ARG A N   1 
ATOM   450  C  CA  . ARG A 1 63  ? 0.70170   21.93649  -7.83151  1.000 32.26716  ? 156 ARG A CA  1 
ATOM   451  C  C   . ARG A 1 63  ? 0.06973   22.41866  -9.13283  1.000 35.29868  ? 156 ARG A C   1 
ATOM   452  O  O   . ARG A 1 63  ? -0.94516  23.12050  -9.13170  1.000 39.00261  ? 156 ARG A O   1 
ATOM   453  C  CB  . ARG A 1 63  ? 0.42392   20.44171  -7.62361  1.000 39.80623  ? 156 ARG A CB  1 
ATOM   454  C  CG  . ARG A 1 63  ? 1.15277   19.89192  -6.40124  1.000 36.47267  ? 156 ARG A CG  1 
ATOM   455  C  CD  . ARG A 1 63  ? 1.51788   18.44816  -6.58699  1.000 36.97248  ? 156 ARG A CD  1 
ATOM   456  N  NE  . ARG A 1 63  ? 0.30098   17.65408  -6.62614  1.000 36.63355  ? 156 ARG A NE  1 
ATOM   457  C  CZ  . ARG A 1 63  ? 0.27296   16.34644  -6.82696  1.000 40.56789  ? 156 ARG A CZ  1 
ATOM   458  N  NH1 . ARG A 1 63  ? 1.38373   15.65707  -7.00746  1.000 39.26677  ? 156 ARG A NH1 1 
ATOM   459  N  NH2 . ARG A 1 63  ? -0.89837  15.71707  -6.84278  1.000 38.11196  ? 156 ARG A NH2 1 
ATOM   460  N  N   . VAL A 1 64  ? 0.68942   22.04485  -10.25709 1.000 36.70398  ? 157 VAL A N   1 
ATOM   461  C  CA  . VAL A 1 64  ? 0.21033   22.40973  -11.59618 1.000 34.25677  ? 157 VAL A CA  1 
ATOM   462  C  C   . VAL A 1 64  ? 0.01366   21.14616  -12.42949 1.000 36.08620  ? 157 VAL A C   1 
ATOM   463  O  O   . VAL A 1 64  ? 0.98863   20.45666  -12.76682 1.000 33.02878  ? 157 VAL A O   1 
ATOM   464  C  CB  . VAL A 1 64  ? 1.18257   23.35038  -12.31705 1.000 34.39950  ? 157 VAL A CB  1 
ATOM   465  C  CG1 . VAL A 1 64  ? 0.55024   23.83503  -13.61257 1.000 33.09303  ? 157 VAL A CG1 1 
ATOM   466  C  CG2 . VAL A 1 64  ? 1.59358   24.50636  -11.42092 1.000 38.51102  ? 157 VAL A CG2 1 
ATOM   467  N  N   . ARG A 1 65  ? -1.22844  20.88092  -12.82185 1.000 37.94538  ? 158 ARG A N   1 
ATOM   468  C  CA  . ARG A 1 65  ? -1.58113  19.67418  -13.56461 1.000 29.43792  ? 158 ARG A CA  1 
ATOM   469  C  C   . ARG A 1 65  ? -1.92469  20.02866  -15.00245 1.000 36.14805  ? 158 ARG A C   1 
ATOM   470  O  O   . ARG A 1 65  ? -2.59931  21.02952  -15.25831 1.000 38.38752  ? 158 ARG A O   1 
ATOM   471  C  CB  . ARG A 1 65  ? -2.77968  18.96913  -12.92573 1.000 34.51742  ? 158 ARG A CB  1 
ATOM   472  C  CG  . ARG A 1 65  ? -3.29580  17.72054  -13.68801 1.000 35.18057  ? 158 ARG A CG  1 
ATOM   473  C  CD  . ARG A 1 65  ? -4.44664  17.10146  -12.94400 1.000 32.84479  ? 158 ARG A CD  1 
ATOM   474  N  NE  . ARG A 1 65  ? -4.14060  17.06045  -11.52222 1.000 33.26800  ? 158 ARG A NE  1 
ATOM   475  C  CZ  . ARG A 1 65  ? -3.48066  16.06515  -10.94159 1.000 41.60068  ? 158 ARG A CZ  1 
ATOM   476  N  NH1 . ARG A 1 65  ? -3.05319  15.01567  -11.63223 1.000 36.32380  ? 158 ARG A NH1 1 
ATOM   477  N  NH2 . ARG A 1 65  ? -3.24410  16.11680  -9.63678  1.000 36.82612  ? 158 ARG A NH2 1 
ATOM   478  N  N   . ALA A 1 66  ? -1.46365  19.21394  -15.93917 1.000 30.91941  ? 159 ALA A N   1 
ATOM   479  C  CA  . ALA A 1 66  ? -1.82109  19.36223  -17.34094 1.000 33.28194  ? 159 ALA A CA  1 
ATOM   480  C  C   . ALA A 1 66  ? -2.61100  18.14585  -17.79690 1.000 35.35586  ? 159 ALA A C   1 
ATOM   481  O  O   . ALA A 1 66  ? -2.26192  17.01176  -17.46375 1.000 36.43139  ? 159 ALA A O   1 
ATOM   482  C  CB  . ALA A 1 66  ? -0.57905  19.54778  -18.21370 1.000 31.62902  ? 159 ALA A CB  1 
ATOM   483  N  N   . MET A 1 67  ? -3.67609  18.38622  -18.56084 1.000 33.59002  ? 160 MET A N   1 
ATOM   484  C  CA  . MET A 1 67  ? -4.51888  17.32343  -19.09553 1.000 35.25935  ? 160 MET A CA  1 
ATOM   485  C  C   . MET A 1 67  ? -5.00581  17.70147  -20.48896 1.000 34.17669  ? 160 MET A C   1 
ATOM   486  O  O   . MET A 1 67  ? -5.40502  18.84701  -20.71264 1.000 42.50392  ? 160 MET A O   1 
ATOM   487  C  CB  . MET A 1 67  ? -5.72243  17.07621  -18.16845 1.000 35.79340  ? 160 MET A CB  1 
ATOM   488  C  CG  . MET A 1 67  ? -6.55655  15.85768  -18.55211 1.000 42.77259  ? 160 MET A CG  1 
ATOM   489  S  SD  . MET A 1 67  ? -8.08536  15.79410  -17.60074 1.000 50.29583  ? 160 MET A SD  1 
ATOM   490  C  CE  . MET A 1 67  ? -7.56188  14.84231  -16.17155 1.000 39.79425  ? 160 MET A CE  1 
ATOM   491  N  N   . ALA A 1 68  ? -4.98083  16.75132  -21.42366 1.000 30.75429  ? 161 ALA A N   1 
ATOM   492  C  CA  . ALA A 1 68  ? -5.60372  16.97431  -22.72340 1.000 34.08375  ? 161 ALA A CA  1 
ATOM   493  C  C   . ALA A 1 68  ? -7.02604  16.43676  -22.74393 1.000 42.57579  ? 161 ALA A C   1 
ATOM   494  O  O   . ALA A 1 68  ? -7.33730  15.42940  -22.11199 1.000 45.48063  ? 161 ALA A O   1 
ATOM   495  C  CB  . ALA A 1 68  ? -4.81335  16.32478  -23.86423 1.000 32.82985  ? 161 ALA A CB  1 
ATOM   496  N  N   . ILE A 1 69  ? -7.90176  17.14003  -23.47127 1.000 38.16729  ? 162 ILE A N   1 
ATOM   497  C  CA  . ILE A 1 69  ? -9.23079  16.64614  -23.82183 1.000 40.90560  ? 162 ILE A CA  1 
ATOM   498  C  C   . ILE A 1 69  ? -9.48719  16.96806  -25.28526 1.000 45.51162  ? 162 ILE A C   1 
ATOM   499  O  O   . ILE A 1 69  ? -8.85615  17.85013  -25.86580 1.000 43.12843  ? 162 ILE A O   1 
ATOM   500  C  CB  . ILE A 1 69  ? -10.37573 17.23376  -22.96188 1.000 40.38338  ? 162 ILE A CB  1 
ATOM   501  C  CG1 . ILE A 1 69  ? -10.80499 18.60405  -23.50562 1.000 49.50753  ? 162 ILE A CG1 1 
ATOM   502  C  CG2 . ILE A 1 69  ? -9.99644  17.30837  -21.49831 1.000 44.52136  ? 162 ILE A CG2 1 
ATOM   503  C  CD1 . ILE A 1 69  ? -11.92949 19.25274  -22.73432 1.000 49.14877  ? 162 ILE A CD1 1 
ATOM   504  N  N   . TYR A 1 70  ? -10.42068 16.23226  -25.88371 1.000 41.79662  ? 163 TYR A N   1 
ATOM   505  C  CA  . TYR A 1 70  ? -10.83433 16.55401  -27.24240 1.000 47.07697  ? 163 TYR A CA  1 
ATOM   506  C  C   . TYR A 1 70  ? -11.68877 17.81623  -27.23236 1.000 45.58087  ? 163 TYR A C   1 
ATOM   507  O  O   . TYR A 1 70  ? -12.45318 18.06324  -26.29492 1.000 46.53950  ? 163 TYR A O   1 
ATOM   508  C  CB  . TYR A 1 70  ? -11.58983 15.38235  -27.87429 1.000 41.03931  ? 163 TYR A CB  1 
ATOM   509  C  CG  . TYR A 1 70  ? -10.64441 14.27610  -28.24770 1.000 45.58742  ? 163 TYR A CG  1 
ATOM   510  C  CD1 . TYR A 1 70  ? -9.75290  14.43848  -29.29447 1.000 41.67309  ? 163 TYR A CD1 1 
ATOM   511  C  CD2 . TYR A 1 70  ? -10.60188 13.09273  -27.52220 1.000 45.47236  ? 163 TYR A CD2 1 
ATOM   512  C  CE1 . TYR A 1 70  ? -8.85889  13.45181  -29.62521 1.000 42.43752  ? 163 TYR A CE1 1 
ATOM   513  C  CE2 . TYR A 1 70  ? -9.71121  12.08287  -27.85458 1.000 41.92224  ? 163 TYR A CE2 1 
ATOM   514  C  CZ  . TYR A 1 70  ? -8.84223  12.27595  -28.90499 1.000 44.16065  ? 163 TYR A CZ  1 
ATOM   515  O  OH  . TYR A 1 70  ? -7.94025  11.29898  -29.24559 1.000 44.71800  ? 163 TYR A OH  1 
ATOM   516  N  N   . LYS A 1 71  ? -11.53841 18.62954  -28.27527 1.000 53.24790  ? 164 LYS A N   1 
ATOM   517  C  CA  . LYS A 1 71  ? -12.22447 19.91684  -28.32220 1.000 47.06834  ? 164 LYS A CA  1 
ATOM   518  C  C   . LYS A 1 71  ? -13.70198 19.75645  -28.67227 1.000 47.55281  ? 164 LYS A C   1 
ATOM   519  O  O   . LYS A 1 71  ? -14.57059 20.30131  -27.97984 1.000 49.88359  ? 164 LYS A O   1 
ATOM   520  C  CB  . LYS A 1 71  ? -11.52207 20.83492  -29.32820 1.000 52.36895  ? 164 LYS A CB  1 
ATOM   521  C  CG  . LYS A 1 71  ? -11.87370 22.31240  -29.18188 1.000 40.23279  ? 164 LYS A CG  1 
ATOM   522  C  CD  . LYS A 1 71  ? -11.18298 23.16686  -30.24015 1.000 49.97016  ? 164 LYS A CD  1 
ATOM   523  C  CE  . LYS A 1 71  ? -11.52782 24.64483  -30.05544 1.000 60.23892  ? 164 LYS A CE  1 
ATOM   524  N  NZ  . LYS A 1 71  ? -10.40487 25.41973  -29.41026 1.000 63.74345  ? 164 LYS A NZ  1 
ATOM   525  N  N   . GLN A 1 72  ? -13.99963 19.00009  -29.73169 1.000 49.54519  ? 165 GLN A N   1 
ATOM   526  C  CA  . GLN A 1 72  ? -15.37411 18.79404  -30.18740 1.000 52.94002  ? 165 GLN A CA  1 
ATOM   527  C  C   . GLN A 1 72  ? -16.21414 18.01392  -29.17415 1.000 59.08329  ? 165 GLN A C   1 
ATOM   528  O  O   . GLN A 1 72  ? -15.75532 17.03276  -28.57991 1.000 54.90746  ? 165 GLN A O   1 
ATOM   529  C  CB  . GLN A 1 72  ? -15.37702 18.05896  -31.52654 1.000 58.21646  ? 165 GLN A CB  1 
ATOM   530  C  CG  . GLN A 1 72  ? -14.67066 18.79702  -32.65271 1.000 49.42587  ? 165 GLN A CG  1 
ATOM   531  C  CD  . GLN A 1 72  ? -13.92822 17.85975  -33.59011 1.000 60.54217  ? 165 GLN A CD  1 
ATOM   532  O  OE1 . GLN A 1 72  ? -13.39467 16.83825  -33.17359 1.000 59.56661  ? 165 GLN A OE1 1 
ATOM   533  N  NE2 . GLN A 1 72  ? -13.90260 18.20438  -34.86961 1.000 76.74956  ? 165 GLN A NE2 1 
ATOM   534  N  N   . SER A 1 73  ? -17.47359 18.44220  -29.01719 1.000 58.49268  ? 166 SER A N   1 
ATOM   535  C  CA  . SER A 1 73  ? -18.36321 17.89135  -27.99574 1.000 58.75206  ? 166 SER A CA  1 
ATOM   536  C  C   . SER A 1 73  ? -18.68584 16.42329  -28.23670 1.000 62.96338  ? 166 SER A C   1 
ATOM   537  O  O   . SER A 1 73  ? -19.00212 15.69336  -27.28374 1.000 60.12928  ? 166 SER A O   1 
ATOM   538  C  CB  . SER A 1 73  ? -19.66665 18.68559  -27.95547 1.000 65.98297  ? 166 SER A CB  1 
ATOM   539  O  OG  . SER A 1 73  ? -20.53723 18.24656  -28.99076 1.000 65.72323  ? 166 SER A OG  1 
ATOM   540  N  N   . GLN A 1 74  ? -18.64763 15.98359  -29.49818 1.000 58.73767  ? 167 GLN A N   1 
ATOM   541  C  CA  . GLN A 1 74  ? -18.86971 14.57603  -29.79709 1.000 61.99875  ? 167 GLN A CA  1 
ATOM   542  C  C   . GLN A 1 74  ? -17.79008 13.70091  -29.17443 1.000 63.65888  ? 167 GLN A C   1 
ATOM   543  O  O   . GLN A 1 74  ? -18.04278 12.53594  -28.84459 1.000 65.44775  ? 167 GLN A O   1 
ATOM   544  C  CB  . GLN A 1 74  ? -18.91986 14.37663  -31.31686 1.000 55.36485  ? 167 GLN A CB  1 
ATOM   545  C  CG  . GLN A 1 74  ? -17.73837 14.98340  -32.04809 1.000 66.48695  ? 167 GLN A CG  1 
ATOM   546  C  CD  . GLN A 1 74  ? -18.12143 15.77126  -33.29191 1.000 72.80197  ? 167 GLN A CD  1 
ATOM   547  O  OE1 . GLN A 1 74  ? -18.03352 15.26895  -34.41440 1.000 72.65498  ? 167 GLN A OE1 1 
ATOM   548  N  NE2 . GLN A 1 74  ? -18.53869 17.01921  -33.09542 1.000 65.99987  ? 167 GLN A NE2 1 
ATOM   549  N  N   . HIS A 1 75  ? -16.59476 14.24962  -28.97996 1.000 57.00799  ? 168 HIS A N   1 
ATOM   550  C  CA  . HIS A 1 75  ? -15.44328 13.46788  -28.57058 1.000 56.94542  ? 168 HIS A CA  1 
ATOM   551  C  C   . HIS A 1 75  ? -14.94406 13.81246  -27.18228 1.000 49.74965  ? 168 HIS A C   1 
ATOM   552  O  O   . HIS A 1 75  ? -14.00950 13.17050  -26.69772 1.000 54.71780  ? 168 HIS A O   1 
ATOM   553  C  CB  . HIS A 1 75  ? -14.32132 13.64946  -29.59303 1.000 53.49043  ? 168 HIS A CB  1 
ATOM   554  C  CG  . HIS A 1 75  ? -14.67540 13.14206  -30.95361 1.000 52.48955  ? 168 HIS A CG  1 
ATOM   555  N  ND1 . HIS A 1 75  ? -14.61808 13.92871  -32.08318 1.000 61.81103  ? 168 HIS A ND1 1 
ATOM   556  C  CD2 . HIS A 1 75  ? -15.09840 11.92620  -31.36449 1.000 58.46177  ? 168 HIS A CD2 1 
ATOM   557  C  CE1 . HIS A 1 75  ? -14.98829 13.22045  -33.13368 1.000 56.50825  ? 168 HIS A CE1 1 
ATOM   558  N  NE2 . HIS A 1 75  ? -15.27760 11.99818  -32.72498 1.000 64.71633  ? 168 HIS A NE2 1 
ATOM   559  N  N   . MET A 1 76  ? -15.54845 14.79059  -26.51714 1.000 57.13396  ? 169 MET A N   1 
ATOM   560  C  CA  . MET A 1 76  ? -15.01058 15.24095  -25.24266 1.000 56.74960  ? 169 MET A CA  1 
ATOM   561  C  C   . MET A 1 76  ? -15.17602 14.20666  -24.13435 1.000 58.70607  ? 169 MET A C   1 
ATOM   562  O  O   . MET A 1 76  ? -14.61194 14.38634  -23.05152 1.000 55.32892  ? 169 MET A O   1 
ATOM   563  C  CB  . MET A 1 76  ? -15.65644 16.57277  -24.86455 1.000 59.26776  ? 169 MET A CB  1 
ATOM   564  C  CG  . MET A 1 76  ? -17.04082 16.44890  -24.26767 1.000 69.81737  ? 169 MET A CG  1 
ATOM   565  S  SD  . MET A 1 76  ? -17.50614 17.91829  -23.32969 1.000 93.94902  ? 169 MET A SD  1 
ATOM   566  C  CE  . MET A 1 76  ? -16.98855 19.23207  -24.43299 1.000 62.21166  ? 169 MET A CE  1 
ATOM   567  N  N   . THR A 1 77  ? -15.91942 13.13176  -24.37847 1.000 57.78968  ? 170 THR A N   1 
ATOM   568  C  CA  . THR A 1 77  ? -16.02101 12.03479  -23.42633 1.000 58.87861  ? 170 THR A CA  1 
ATOM   569  C  C   . THR A 1 77  ? -14.97560 10.94359  -23.64643 1.000 48.74600  ? 170 THR A C   1 
ATOM   570  O  O   . THR A 1 77  ? -14.82329 10.07244  -22.78281 1.000 53.84784  ? 170 THR A O   1 
ATOM   571  C  CB  . THR A 1 77  ? -17.42570 11.43881  -23.49083 1.000 59.30764  ? 170 THR A CB  1 
ATOM   572  O  OG1 . THR A 1 77  ? -17.75052 11.13807  -24.85618 1.000 65.07063  ? 170 THR A OG1 1 
ATOM   573  C  CG2 . THR A 1 77  ? -18.40580 12.46137  -22.97249 1.000 62.60730  ? 170 THR A CG2 1 
ATOM   574  N  N   . GLU A 1 78  ? -14.23766 10.98694  -24.75672 1.000 49.87967  ? 171 GLU A N   1 
ATOM   575  C  CA  . GLU A 1 78  ? -13.20221 10.00339  -25.05505 1.000 52.93843  ? 171 GLU A CA  1 
ATOM   576  C  C   . GLU A 1 78  ? -11.84419 10.45664  -24.51385 1.000 58.28772  ? 171 GLU A C   1 
ATOM   577  O  O   . GLU A 1 78  ? -11.50337 11.64244  -24.57325 1.000 50.10023  ? 171 GLU A O   1 
ATOM   578  C  CB  . GLU A 1 78  ? -13.11455 9.77792   -26.56291 1.000 45.40814  ? 171 GLU A CB  1 
ATOM   579  C  CG  . GLU A 1 78  ? -11.92496 8.92732   -26.97466 1.000 51.40794  ? 171 GLU A CG  1 
ATOM   580  C  CD  . GLU A 1 78  ? -11.85547 8.67937   -28.45617 1.000 54.02193  ? 171 GLU A CD  1 
ATOM   581  O  OE1 . GLU A 1 78  ? -10.81887 8.15495   -28.91997 1.000 56.85912  ? 171 GLU A OE1 1 
ATOM   582  O  OE2 . GLU A 1 78  ? -12.83447 9.00905   -29.15678 1.000 62.57027  ? 171 GLU A OE2 1 
ATOM   583  N  N   . VAL A 1 79  ? -11.06339 9.50372   -23.99647 1.000 49.36776  ? 172 VAL A N   1 
ATOM   584  C  CA  . VAL A 1 79  ? -9.80246  9.81758   -23.33119 1.000 46.37035  ? 172 VAL A CA  1 
ATOM   585  C  C   . VAL A 1 79  ? -8.71695  10.05042  -24.37460 1.000 51.52537  ? 172 VAL A C   1 
ATOM   586  O  O   . VAL A 1 79  ? -8.50571  9.21290   -25.25692 1.000 43.56633  ? 172 VAL A O   1 
ATOM   587  C  CB  . VAL A 1 79  ? -9.40559  8.69305   -22.36259 1.000 52.21985  ? 172 VAL A CB  1 
ATOM   588  C  CG1 . VAL A 1 79  ? -7.97195  8.89597   -21.88306 1.000 46.65631  ? 172 VAL A CG1 1 
ATOM   589  C  CG2 . VAL A 1 79  ? -10.37454 8.64399   -21.19163 1.000 50.30857  ? 172 VAL A CG2 1 
ATOM   590  N  N   . VAL A 1 80  ? -8.02467  11.19018  -24.27492 1.000 46.26042  ? 173 VAL A N   1 
ATOM   591  C  CA  . VAL A 1 80  ? -6.88684  11.47551  -25.14685 1.000 44.33089  ? 173 VAL A CA  1 
ATOM   592  C  C   . VAL A 1 80  ? -5.69889  10.63684  -24.70255 1.000 36.94173  ? 173 VAL A C   1 
ATOM   593  O  O   . VAL A 1 80  ? -5.18752  10.81425  -23.59091 1.000 39.71700  ? 173 VAL A O   1 
ATOM   594  C  CB  . VAL A 1 80  ? -6.52242  12.97046  -25.11981 1.000 47.11740  ? 173 VAL A CB  1 
ATOM   595  C  CG1 . VAL A 1 80  ? -5.35212  13.23918  -26.06083 1.000 38.27297  ? 173 VAL A CG1 1 
ATOM   596  C  CG2 . VAL A 1 80  ? -7.69118  13.80978  -25.50235 1.000 35.18187  ? 173 VAL A CG2 1 
ATOM   597  N  N   . ARG A 1 81  ? -5.24058  9.74488   -25.58033 1.000 39.39065  ? 174 ARG A N   1 
ATOM   598  C  CA  . ARG A 1 81  ? -4.09970  8.87399   -25.31306 1.000 40.45080  ? 174 ARG A CA  1 
ATOM   599  C  C   . ARG A 1 81  ? -3.22111  8.84005   -26.55460 1.000 36.51683  ? 174 ARG A C   1 
ATOM   600  O  O   . ARG A 1 81  ? -3.65790  9.19588   -27.64530 1.000 39.96940  ? 174 ARG A O   1 
ATOM   601  C  CB  . ARG A 1 81  ? -4.54355  7.43573   -24.92945 1.000 41.39699  ? 174 ARG A CB  1 
ATOM   602  C  CG  . ARG A 1 81  ? -5.64562  6.85107   -25.84246 1.000 52.83749  ? 174 ARG A CG  1 
ATOM   603  C  CD  . ARG A 1 81  ? -6.11159  5.41944   -25.45519 1.000 57.12361  ? 174 ARG A CD  1 
ATOM   604  N  NE  . ARG A 1 81  ? -7.18074  5.38767   -24.46265 1.000 58.32154  ? 174 ARG A NE  1 
ATOM   605  C  CZ  . ARG A 1 81  ? -6.97764  5.15104   -23.17458 1.000 53.59840  ? 174 ARG A CZ  1 
ATOM   606  N  NH1 . ARG A 1 81  ? -5.75659  5.00320   -22.69247 1.000 49.14034  ? 174 ARG A NH1 1 
ATOM   607  N  NH2 . ARG A 1 81  ? -8.02437  5.06110   -22.35008 1.000 51.26487  ? 174 ARG A NH2 1 
ATOM   608  N  N   . ARG A 1 82  ? -1.97182  8.41512   -26.38253 1.000 38.44697  ? 175 ARG A N   1 
ATOM   609  C  CA  . ARG A 1 82  ? -1.11833  8.15038   -27.53491 1.000 38.41579  ? 175 ARG A CA  1 
ATOM   610  C  C   . ARG A 1 82  ? -1.66692  6.99230   -28.36305 1.000 45.65018  ? 175 ARG A C   1 
ATOM   611  O  O   . ARG A 1 82  ? -2.31044  6.08112   -27.84252 1.000 41.08206  ? 175 ARG A O   1 
ATOM   612  C  CB  . ARG A 1 82  ? 0.29666   7.79579   -27.09354 1.000 40.57053  ? 175 ARG A CB  1 
ATOM   613  C  CG  . ARG A 1 82  ? 1.06944   8.92633   -26.53016 1.000 34.41896  ? 175 ARG A CG  1 
ATOM   614  C  CD  . ARG A 1 82  ? 2.40352   8.44684   -26.06299 1.000 40.51239  ? 175 ARG A CD  1 
ATOM   615  N  NE  . ARG A 1 82  ? 3.41219   8.48189   -27.11012 1.000 39.25725  ? 175 ARG A NE  1 
ATOM   616  C  CZ  . ARG A 1 82  ? 4.61989   7.95523   -26.97876 1.000 38.90328  ? 175 ARG A CZ  1 
ATOM   617  N  NH1 . ARG A 1 82  ? 4.95504   7.27097   -25.90384 1.000 36.29990  ? 175 ARG A NH1 1 
ATOM   618  N  NH2 . ARG A 1 82  ? 5.51752   8.13128   -27.94391 1.000 41.71667  ? 175 ARG A NH2 1 
ATOM   619  N  N   . CYS A 1 83  ? -1.35669  7.02252   -29.66002 1.000 42.18634  ? 176 CYS A N   1 
ATOM   620  C  CA  . CYS A 1 83  ? -1.85722  6.06448   -30.62684 1.000 45.93088  ? 176 CYS A CA  1 
ATOM   621  C  C   . CYS A 1 83  ? -1.24159  4.68770   -30.37559 1.000 48.19605  ? 176 CYS A C   1 
ATOM   622  O  O   . CYS A 1 83  ? -0.21604  4.58043   -29.69943 1.000 42.78445  ? 176 CYS A O   1 
ATOM   623  C  CB  . CYS A 1 83  ? -1.55231  6.55949   -32.04907 1.000 34.80071  ? 176 CYS A CB  1 
ATOM   624  S  SG  . CYS A 1 83  ? 0.15264   6.37781   -32.63811 1.000 42.27550  ? 176 CYS A SG  1 
ATOM   625  N  N   . PRO A 1 84  ? -1.86183  3.61609   -30.89954 1.000 49.42591  ? 177 PRO A N   1 
ATOM   626  C  CA  . PRO A 1 84  ? -1.28654  2.26742   -30.72606 1.000 41.89388  ? 177 PRO A CA  1 
ATOM   627  C  C   . PRO A 1 84  ? 0.14292   2.12792   -31.20893 1.000 40.72001  ? 177 PRO A C   1 
ATOM   628  O  O   . PRO A 1 84  ? 0.85945   1.25302   -30.71619 1.000 43.34591  ? 177 PRO A O   1 
ATOM   629  C  CB  . PRO A 1 84  ? -2.22989  1.38386   -31.54847 1.000 42.94477  ? 177 PRO A CB  1 
ATOM   630  C  CG  . PRO A 1 84  ? -3.54559  2.07326   -31.43624 1.000 50.83304  ? 177 PRO A CG  1 
ATOM   631  C  CD  . PRO A 1 84  ? -3.22923  3.54653   -31.45968 1.000 46.58687  ? 177 PRO A CD  1 
ATOM   632  N  N   . HIS A 1 85  ? 0.59195   2.96058   -32.14042 1.000 39.23044  ? 178 HIS A N   1 
ATOM   633  C  CA  . HIS A 1 85  ? 1.97212   2.83857   -32.58964 1.000 32.90081  ? 178 HIS A CA  1 
ATOM   634  C  C   . HIS A 1 85  ? 2.93653   3.58533   -31.68011 1.000 47.41141  ? 178 HIS A C   1 
ATOM   635  O  O   . HIS A 1 85  ? 3.99681   3.04438   -31.34589 1.000 39.16719  ? 178 HIS A O   1 
ATOM   636  C  CB  . HIS A 1 85  ? 2.07938   3.31497   -34.03517 1.000 39.44183  ? 178 HIS A CB  1 
ATOM   637  C  CG  . HIS A 1 85  ? 1.11414   2.62117   -34.94222 1.000 61.85956  ? 178 HIS A CG  1 
ATOM   638  N  ND1 . HIS A 1 85  ? 0.66021   1.34038   -34.69510 1.000 57.51579  ? 178 HIS A ND1 1 
ATOM   639  C  CD2 . HIS A 1 85  ? 0.50724   3.02223   -36.08402 1.000 73.74991  ? 178 HIS A CD2 1 
ATOM   640  C  CE1 . HIS A 1 85  ? -0.18304  0.98299   -35.64609 1.000 57.75074  ? 178 HIS A CE1 1 
ATOM   641  N  NE2 . HIS A 1 85  ? -0.29128  1.98364   -36.50312 1.000 68.50720  ? 178 HIS A NE2 1 
ATOM   642  N  N   . HIS A 1 86  ? 2.58704   4.81194   -31.24615 1.000 41.03073  ? 179 HIS A N   1 
ATOM   643  C  CA  . HIS A 1 86  ? 3.52197   5.57042   -30.41450 1.000 40.63180  ? 179 HIS A CA  1 
ATOM   644  C  C   . HIS A 1 86  ? 3.62660   4.99870   -29.00318 1.000 40.76189  ? 179 HIS A C   1 
ATOM   645  O  O   . HIS A 1 86  ? 4.68586   5.10744   -28.37289 1.000 40.91388  ? 179 HIS A O   1 
ATOM   646  C  CB  . HIS A 1 86  ? 3.13203   7.05683   -30.37476 1.000 43.23892  ? 179 HIS A CB  1 
ATOM   647  C  CG  . HIS A 1 86  ? 3.59525   7.83155   -31.56985 1.000 42.42758  ? 179 HIS A CG  1 
ATOM   648  N  ND1 . HIS A 1 86  ? 2.71875   8.35421   -32.49760 1.000 34.37056  ? 179 HIS A ND1 1 
ATOM   649  C  CD2 . HIS A 1 86  ? 4.83976   8.15159   -32.00543 1.000 36.75863  ? 179 HIS A CD2 1 
ATOM   650  C  CE1 . HIS A 1 86  ? 3.39515   8.96579   -33.45391 1.000 37.95374  ? 179 HIS A CE1 1 
ATOM   651  N  NE2 . HIS A 1 86  ? 4.68600   8.85833   -33.17889 1.000 43.51690  ? 179 HIS A NE2 1 
ATOM   652  N  N   . GLU A 1 87  ? 2.56914   4.36590   -28.49332 1.000 37.35095  ? 180 GLU A N   1 
ATOM   653  C  CA  . GLU A 1 87  ? 2.67093   3.78117   -27.15700 1.000 37.79311  ? 180 GLU A CA  1 
ATOM   654  C  C   . GLU A 1 87  ? 3.63688   2.59634   -27.09734 1.000 38.96267  ? 180 GLU A C   1 
ATOM   655  O  O   . GLU A 1 87  ? 4.06106   2.21523   -26.00236 1.000 41.00247  ? 180 GLU A O   1 
ATOM   656  C  CB  . GLU A 1 87  ? 1.28705   3.35914   -26.66296 1.000 39.60799  ? 180 GLU A CB  1 
ATOM   657  C  CG  . GLU A 1 87  ? 0.78912   2.00214   -27.20425 1.000 44.50604  ? 180 GLU A CG  1 
ATOM   658  C  CD  . GLU A 1 87  ? -0.51555  1.55622   -26.54519 1.000 44.02843  ? 180 GLU A CD  1 
ATOM   659  O  OE1 . GLU A 1 87  ? -1.14610  2.38815   -25.84943 1.000 46.66407  ? 180 GLU A OE1 1 
ATOM   660  O  OE2 . GLU A 1 87  ? -0.89710  0.37011   -26.69674 1.000 49.57688  ? 180 GLU A OE2 1 
ATOM   661  N  N   . ARG A 1 88  ? 4.02052   2.03716   -28.23646 1.000 37.87667  ? 181 ARG A N   1 
ATOM   662  C  CA  . ARG A 1 88  ? 4.97906   0.94501   -28.29501 1.000 42.16647  ? 181 ARG A CA  1 
ATOM   663  C  C   . ARG A 1 88  ? 6.39383   1.41663   -28.58163 1.000 45.76670  ? 181 ARG A C   1 
ATOM   664  O  O   . ARG A 1 88  ? 7.29566   0.58476   -28.69296 1.000 48.88474  ? 181 ARG A O   1 
ATOM   665  C  CB  . ARG A 1 88  ? 4.53965   -0.07888  -29.35529 1.000 38.44936  ? 181 ARG A CB  1 
ATOM   666  C  CG  . ARG A 1 88  ? 3.19201   -0.71967  -29.02027 1.000 39.36853  ? 181 ARG A CG  1 
ATOM   667  C  CD  . ARG A 1 88  ? 2.78624   -1.85991  -29.96554 1.000 37.63165  ? 181 ARG A CD  1 
ATOM   668  N  NE  . ARG A 1 88  ? 3.59218   -3.05734  -29.77938 1.000 41.54785  ? 181 ARG A NE  1 
ATOM   669  C  CZ  . ARG A 1 88  ? 4.23902   -3.68120  -30.75997 1.000 46.98166  ? 181 ARG A CZ  1 
ATOM   670  N  NH1 . ARG A 1 88  ? 4.19166   -3.24718  -32.01131 1.000 34.54051  ? 181 ARG A NH1 1 
ATOM   671  N  NH2 . ARG A 1 88  ? 4.95285   -4.76897  -30.48043 1.000 42.58970  ? 181 ARG A NH2 1 
ATOM   672  N  N   . CYS A 1 89  ? 6.61742   2.71926   -28.71591 1.000 40.54222  ? 182 CYS A N   1 
ATOM   673  C  CA  . CYS A 1 89  ? 7.97995   3.19830   -28.91161 1.000 47.67217  ? 182 CYS A CA  1 
ATOM   674  C  C   . CYS A 1 89  ? 8.79045   3.01392   -27.64045 1.000 50.47760  ? 182 CYS A C   1 
ATOM   675  O  O   . CYS A 1 89  ? 8.25188   2.91971   -26.53307 1.000 57.97810  ? 182 CYS A O   1 
ATOM   676  C  CB  . CYS A 1 89  ? 7.99451   4.67379   -29.29912 1.000 52.14799  ? 182 CYS A CB  1 
ATOM   677  S  SG  . CYS A 1 89  ? 7.09060   5.03628   -30.79246 1.000 61.58484  ? 182 CYS A SG  1 
ATOM   678  N  N   . SER A 1 90  ? 10.10231  2.95632   -27.79981 1.000 51.30909  ? 183 SER A N   1 
ATOM   679  C  CA  . SER A 1 90  ? 10.97090  2.71897   -26.64700 1.000 67.25337  ? 183 SER A CA  1 
ATOM   680  C  C   . SER A 1 90  ? 11.50185  4.04717   -26.11123 1.000 63.64644  ? 183 SER A C   1 
ATOM   681  O  O   . SER A 1 90  ? 12.70610  4.30459   -26.09871 1.000 66.34477  ? 183 SER A O   1 
ATOM   682  C  CB  . SER A 1 90  ? 12.10215  1.76530   -27.02964 1.000 59.77799  ? 183 SER A CB  1 
ATOM   683  N  N   . ASP A 1 91  ? 10.57146  4.90323   -25.65671 1.000 67.47568  ? 184 ASP A N   1 
ATOM   684  C  CA  . ASP A 1 91  ? 10.88714  6.31625   -25.47514 1.000 46.35234  ? 184 ASP A CA  1 
ATOM   685  C  C   . ASP A 1 91  ? 10.57362  6.86992   -24.08549 1.000 56.05921  ? 184 ASP A C   1 
ATOM   686  O  O   . ASP A 1 91  ? 10.64788  8.09172   -23.89081 1.000 53.58980  ? 184 ASP A O   1 
ATOM   687  C  CB  . ASP A 1 91  ? 10.18749  7.16077   -26.55895 1.000 51.72142  ? 184 ASP A CB  1 
ATOM   688  C  CG  . ASP A 1 91  ? 8.65492   7.05537   -26.54481 1.000 49.58475  ? 184 ASP A CG  1 
ATOM   689  O  OD1 . ASP A 1 91  ? 8.05009   6.56281   -25.56960 1.000 50.04013  ? 184 ASP A OD1 1 
ATOM   690  O  OD2 . ASP A 1 91  ? 8.04294   7.54050   -27.52575 1.000 45.80559  ? 184 ASP A OD2 1 
ATOM   691  N  N   . SER A 1 92  ? 10.26418  6.02261   -23.10625 1.000 52.60442  ? 185 SER A N   1 
ATOM   692  C  CA  . SER A 1 92  ? 9.92743   6.52546   -21.77934 1.000 59.74624  ? 185 SER A CA  1 
ATOM   693  C  C   . SER A 1 92  ? 11.17082  7.00969   -21.04461 1.000 66.56025  ? 185 SER A C   1 
ATOM   694  O  O   . SER A 1 92  ? 12.12611  6.25164   -20.86065 1.000 70.29336  ? 185 SER A O   1 
ATOM   695  C  CB  . SER A 1 92  ? 9.23438   5.44198   -20.96055 1.000 60.82696  ? 185 SER A CB  1 
ATOM   696  O  OG  . SER A 1 92  ? 7.82345   5.55867   -21.06636 1.000 64.21411  ? 185 SER A OG  1 
ATOM   697  N  N   . ASP A 1 93  ? 11.13118  8.25909   -20.56821 1.000 48.98149  ? 186 ASP A N   1 
ATOM   698  C  CA  . ASP A 1 93  ? 12.19717  8.82136   -19.74955 1.000 54.93057  ? 186 ASP A CA  1 
ATOM   699  C  C   . ASP A 1 93  ? 12.32037  8.16037   -18.37882 1.000 57.74843  ? 186 ASP A C   1 
ATOM   700  O  O   . ASP A 1 93  ? 13.12328  8.62931   -17.56542 1.000 65.99396  ? 186 ASP A O   1 
ATOM   701  C  CB  . ASP A 1 93  ? 11.99087  10.32321  -19.55641 1.000 55.38267  ? 186 ASP A CB  1 
ATOM   702  C  CG  . ASP A 1 93  ? 10.55983  10.68085  -19.12527 1.000 63.51693  ? 186 ASP A CG  1 
ATOM   703  O  OD1 . ASP A 1 93  ? 9.95281   9.92002   -18.33058 1.000 60.50075  ? 186 ASP A OD1 1 
ATOM   704  O  OD2 . ASP A 1 93  ? 10.04961  11.74127  -19.56729 1.000 54.34053  ? 186 ASP A OD2 1 
ATOM   705  N  N   . GLY A 1 94  ? 11.54064  7.12042   -18.08725 1.000 61.29060  ? 187 GLY A N   1 
ATOM   706  C  CA  . GLY A 1 94  ? 11.54783  6.48662   -16.78967 1.000 58.92336  ? 187 GLY A CA  1 
ATOM   707  C  C   . GLY A 1 94  ? 10.51977  7.03575   -15.83410 1.000 61.49500  ? 187 GLY A C   1 
ATOM   708  O  O   . GLY A 1 94  ? 10.26593  6.41091   -14.79374 1.000 52.71488  ? 187 GLY A O   1 
ATOM   709  N  N   . LEU A 1 95  ? 9.91576   8.17883   -16.16376 1.000 57.68710  ? 188 LEU A N   1 
ATOM   710  C  CA  . LEU A 1 95  ? 8.82971   8.77287   -15.40039 1.000 51.55104  ? 188 LEU A CA  1 
ATOM   711  C  C   . LEU A 1 95  ? 7.49281   8.66826   -16.11508 1.000 46.28828  ? 188 LEU A C   1 
ATOM   712  O  O   . LEU A 1 95  ? 6.51055   8.21001   -15.52491 1.000 42.32533  ? 188 LEU A O   1 
ATOM   713  C  CB  . LEU A 1 95  ? 9.14598   10.24190  -15.11286 1.000 55.10700  ? 188 LEU A CB  1 
ATOM   714  C  CG  . LEU A 1 95  ? 10.18955  10.45628  -14.02859 1.000 64.51572  ? 188 LEU A CG  1 
ATOM   715  C  CD1 . LEU A 1 95  ? 10.36479  11.95126  -13.78126 1.000 53.13270  ? 188 LEU A CD1 1 
ATOM   716  C  CD2 . LEU A 1 95  ? 9.77041   9.71443   -12.75922 1.000 63.71584  ? 188 LEU A CD2 1 
ATOM   717  N  N   . ALA A 1 96  ? 7.43385   9.07161   -17.38049 1.000 39.40151  ? 189 ALA A N   1 
ATOM   718  C  CA  . ALA A 1 96  ? 6.16300   9.08581   -18.09477 1.000 42.33081  ? 189 ALA A CA  1 
ATOM   719  C  C   . ALA A 1 96  ? 5.76520   7.67624   -18.50311 1.000 44.31486  ? 189 ALA A C   1 
ATOM   720  O  O   . ALA A 1 96  ? 6.54568   6.98703   -19.16321 1.000 46.02444  ? 189 ALA A O   1 
ATOM   721  C  CB  . ALA A 1 96  ? 6.24303   9.95870   -19.33360 1.000 41.18841  ? 189 ALA A CB  1 
ATOM   722  N  N   . PRO A 1 97  ? 4.56910   7.21999   -18.14190 1.000 41.77649  ? 190 PRO A N   1 
ATOM   723  C  CA  . PRO A 1 97  ? 4.08148   5.96381   -18.69606 1.000 42.75725  ? 190 PRO A CA  1 
ATOM   724  C  C   . PRO A 1 97  ? 3.91169   6.08213   -20.19424 1.000 38.08401  ? 190 PRO A C   1 
ATOM   725  O  O   . PRO A 1 97  ? 3.63336   7.17460   -20.72682 1.000 40.54689  ? 190 PRO A O   1 
ATOM   726  C  CB  . PRO A 1 97  ? 2.73896   5.75141   -17.97684 1.000 38.22656  ? 190 PRO A CB  1 
ATOM   727  C  CG  . PRO A 1 97  ? 2.40681   7.05704   -17.36005 1.000 47.04969  ? 190 PRO A CG  1 
ATOM   728  C  CD  . PRO A 1 97  ? 3.69522   7.74168   -17.08854 1.000 37.49491  ? 190 PRO A CD  1 
ATOM   729  N  N   . PRO A 1 98  ? 4.09944   4.98241   -20.92569 1.000 38.85038  ? 191 PRO A N   1 
ATOM   730  C  CA  . PRO A 1 98  ? 4.19341   5.06360   -22.39340 1.000 36.14606  ? 191 PRO A CA  1 
ATOM   731  C  C   . PRO A 1 98  ? 2.92678   5.52801   -23.09604 1.000 36.90323  ? 191 PRO A C   1 
ATOM   732  O  O   . PRO A 1 98  ? 3.02574   5.99183   -24.23396 1.000 32.66992  ? 191 PRO A O   1 
ATOM   733  C  CB  . PRO A 1 98  ? 4.56792   3.62627   -22.79245 1.000 36.03935  ? 191 PRO A CB  1 
ATOM   734  C  CG  . PRO A 1 98  ? 4.12048   2.77295   -21.62583 1.000 43.17387  ? 191 PRO A CG  1 
ATOM   735  C  CD  . PRO A 1 98  ? 4.36106   3.62017   -20.41933 1.000 41.60968  ? 191 PRO A CD  1 
ATOM   736  N  N   . GLN A 1 99  ? 1.75237   5.43583   -22.46784 1.000 29.93371  ? 192 GLN A N   1 
ATOM   737  C  CA  . GLN A 1 99  ? 0.50553   5.84532   -23.10781 1.000 31.05353  ? 192 GLN A CA  1 
ATOM   738  C  C   . GLN A 1 99  ? 0.20304   7.34856   -22.98737 1.000 43.07635  ? 192 GLN A C   1 
ATOM   739  O  O   . GLN A 1 99  ? -0.75055  7.82568   -23.61442 1.000 33.99069  ? 192 GLN A O   1 
ATOM   740  C  CB  . GLN A 1 99  ? -0.66304  5.06403   -22.50529 1.000 29.91025  ? 192 GLN A CB  1 
ATOM   741  C  CG  . GLN A 1 99  ? -0.39664  3.54280   -22.33298 1.000 40.16791  ? 192 GLN A CG  1 
ATOM   742  C  CD  . GLN A 1 99  ? 0.16642   3.19151   -20.95338 1.000 51.32476  ? 192 GLN A CD  1 
ATOM   743  O  OE1 . GLN A 1 99  ? 1.06559   3.87822   -20.44175 1.000 54.04964  ? 192 GLN A OE1 1 
ATOM   744  N  NE2 . GLN A 1 99  ? -0.35434  2.12616   -20.34866 1.000 51.35418  ? 192 GLN A NE2 1 
ATOM   745  N  N   . HIS A 1 100 ? 0.94905   8.10173   -22.18465 1.000 36.44274  ? 193 HIS A N   1 
ATOM   746  C  CA  . HIS A 1 100 ? 0.57572   9.48226   -21.90443 1.000 33.88584  ? 193 HIS A CA  1 
ATOM   747  C  C   . HIS A 1 100 ? 1.04330   10.40595  -23.01778 1.000 34.20329  ? 193 HIS A C   1 
ATOM   748  O  O   . HIS A 1 100 ? 2.21849   10.39525  -23.39141 1.000 35.54657  ? 193 HIS A O   1 
ATOM   749  C  CB  . HIS A 1 100 ? 1.16969   9.94489   -20.58448 1.000 30.47370  ? 193 HIS A CB  1 
ATOM   750  C  CG  . HIS A 1 100 ? 0.41737   9.46504   -19.39021 1.000 33.84428  ? 193 HIS A CG  1 
ATOM   751  N  ND1 . HIS A 1 100 ? 0.23298   10.24153  -18.26538 1.000 35.56744  ? 193 HIS A ND1 1 
ATOM   752  C  CD2 . HIS A 1 100 ? -0.18625  8.27632   -19.13972 1.000 37.25776  ? 193 HIS A CD2 1 
ATOM   753  C  CE1 . HIS A 1 100 ? -0.45445  9.54771   -17.37186 1.000 41.88627  ? 193 HIS A CE1 1 
ATOM   754  N  NE2 . HIS A 1 100 ? -0.71603  8.35093   -17.87514 1.000 36.82202  ? 193 HIS A NE2 1 
ATOM   755  N  N   . LEU A 1 101 ? 0.11721   11.21577  -23.53094 1.000 32.07948  ? 194 LEU A N   1 
ATOM   756  C  CA  . LEU A 1 101 ? 0.43840   12.16433  -24.58970 1.000 33.48055  ? 194 LEU A CA  1 
ATOM   757  C  C   . LEU A 1 101 ? 1.31605   13.30498  -24.08571 1.000 35.84955  ? 194 LEU A C   1 
ATOM   758  O  O   . LEU A 1 101 ? 2.24895   13.73041  -24.78005 1.000 36.33501  ? 194 LEU A O   1 
ATOM   759  C  CB  . LEU A 1 101 ? -0.85113  12.72968  -25.17964 1.000 37.02730  ? 194 LEU A CB  1 
ATOM   760  C  CG  . LEU A 1 101 ? -0.61226  13.96004  -26.04692 1.000 41.87089  ? 194 LEU A CG  1 
ATOM   761  C  CD1 . LEU A 1 101 ? 0.07708   13.50935  -27.31113 1.000 35.52048  ? 194 LEU A CD1 1 
ATOM   762  C  CD2 . LEU A 1 101 ? -1.89659  14.72814  -26.34991 1.000 34.24059  ? 194 LEU A CD2 1 
ATOM   763  N  N   . ILE A 1 102 ? 1.02414   13.82829  -22.89669 1.000 30.95968  ? 195 ILE A N   1 
ATOM   764  C  CA  . ILE A 1 102 ? 1.68028   15.02552  -22.38694 1.000 36.69777  ? 195 ILE A CA  1 
ATOM   765  C  C   . ILE A 1 102 ? 2.72215   14.61982  -21.36056 1.000 33.00945  ? 195 ILE A C   1 
ATOM   766  O  O   . ILE A 1 102 ? 2.39499   13.99594  -20.34598 1.000 36.68016  ? 195 ILE A O   1 
ATOM   767  C  CB  . ILE A 1 102 ? 0.67754   16.00457  -21.76005 1.000 35.71913  ? 195 ILE A CB  1 
ATOM   768  C  CG1 . ILE A 1 102 ? -0.43660  16.38448  -22.74336 1.000 35.02667  ? 195 ILE A CG1 1 
ATOM   769  C  CG2 . ILE A 1 102 ? 1.41320   17.26172  -21.26023 1.000 33.30758  ? 195 ILE A CG2 1 
ATOM   770  C  CD1 . ILE A 1 102 ? -1.41328  17.46111  -22.16735 1.000 28.03371  ? 195 ILE A CD1 1 
ATOM   771  N  N   . ARG A 1 103 ? 3.96469   15.02004  -21.59123 1.000 33.63005  ? 196 ARG A N   1 
ATOM   772  C  CA  . ARG A 1 103 ? 5.03050   14.84058  -20.62420 1.000 34.77143  ? 196 ARG A CA  1 
ATOM   773  C  C   . ARG A 1 103 ? 5.53432   16.19420  -20.14603 1.000 35.77958  ? 196 ARG A C   1 
ATOM   774  O  O   . ARG A 1 103 ? 5.42632   17.19374  -20.85707 1.000 36.92609  ? 196 ARG A O   1 
ATOM   775  C  CB  . ARG A 1 103 ? 6.18856   14.06602  -21.24143 1.000 36.25569  ? 196 ARG A CB  1 
ATOM   776  C  CG  . ARG A 1 103 ? 5.80821   12.69187  -21.73059 1.000 39.67852  ? 196 ARG A CG  1 
ATOM   777  C  CD  . ARG A 1 103 ? 7.04001   11.98238  -22.19487 1.000 47.02519  ? 196 ARG A CD  1 
ATOM   778  N  NE  . ARG A 1 103 ? 6.77339   10.64257  -22.69045 1.000 42.60172  ? 196 ARG A NE  1 
ATOM   779  C  CZ  . ARG A 1 103 ? 7.70460   9.87592   -23.23939 1.000 51.80805  ? 196 ARG A CZ  1 
ATOM   780  N  NH1 . ARG A 1 103 ? 8.94861   10.30606  -23.38444 1.000 43.89737  ? 196 ARG A NH1 1 
ATOM   781  N  NH2 . ARG A 1 103 ? 7.38361   8.64625   -23.64575 1.000 44.68715  ? 196 ARG A NH2 1 
ATOM   782  N  N   . VAL A 1 104 ? 6.08745   16.22676  -18.93471 1.000 37.06604  ? 197 VAL A N   1 
ATOM   783  C  CA  . VAL A 1 104 ? 6.86040   17.36827  -18.46984 1.000 40.08574  ? 197 VAL A CA  1 
ATOM   784  C  C   . VAL A 1 104 ? 8.32922   17.04393  -18.65811 1.000 42.78972  ? 197 VAL A C   1 
ATOM   785  O  O   . VAL A 1 104 ? 8.78725   15.95493  -18.28293 1.000 39.34528  ? 197 VAL A O   1 
ATOM   786  C  CB  . VAL A 1 104 ? 6.55867   17.71829  -17.00208 1.000 46.19302  ? 197 VAL A CB  1 
ATOM   787  C  CG1 . VAL A 1 104 ? 7.54387   18.76605  -16.50081 1.000 39.40525  ? 197 VAL A CG1 1 
ATOM   788  C  CG2 . VAL A 1 104 ? 5.15693   18.27653  -16.86753 1.000 38.21343  ? 197 VAL A CG2 1 
ATOM   789  N  N   . GLU A 1 105 ? 9.06672   17.98660  -19.23647 1.000 39.56668  ? 198 GLU A N   1 
ATOM   790  C  CA  . GLU A 1 105 ? 10.49565  17.84798  -19.45849 1.000 47.20104  ? 198 GLU A CA  1 
ATOM   791  C  C   . GLU A 1 105 ? 11.28284  18.54488  -18.34552 1.000 48.95958  ? 198 GLU A C   1 
ATOM   792  O  O   . GLU A 1 105 ? 10.95262  19.66608  -17.94038 1.000 41.78319  ? 198 GLU A O   1 
ATOM   793  C  CB  . GLU A 1 105 ? 10.84747  18.41961  -20.83755 1.000 46.28777  ? 198 GLU A CB  1 
ATOM   794  C  CG  . GLU A 1 105 ? 12.21206  19.04905  -20.95883 1.000 60.07461  ? 198 GLU A CG  1 
ATOM   795  C  CD  . GLU A 1 105 ? 12.65575  19.19668  -22.40564 1.000 65.28385  ? 198 GLU A CD  1 
ATOM   796  O  OE1 . GLU A 1 105 ? 11.77815  19.27948  -23.29636 1.000 64.28914  ? 198 GLU A OE1 1 
ATOM   797  O  OE2 . GLU A 1 105 ? 13.88208  19.22727  -22.65102 1.000 74.25776  ? 198 GLU A OE2 1 
ATOM   798  N  N   . GLY A 1 106 ? 12.30867  17.86262  -17.84007 1.000 47.17524  ? 199 GLY A N   1 
ATOM   799  C  CA  . GLY A 1 106 ? 13.28256  18.45578  -16.92906 1.000 47.71046  ? 199 GLY A CA  1 
ATOM   800  C  C   . GLY A 1 106 ? 12.79821  18.77641  -15.52917 1.000 57.37815  ? 199 GLY A C   1 
ATOM   801  O  O   . GLY A 1 106 ? 13.13234  19.84135  -14.98479 1.000 57.79452  ? 199 GLY A O   1 
ATOM   802  N  N   . ASN A 1 107 ? 12.03630  17.87138  -14.92318 1.000 46.41634  ? 200 ASN A N   1 
ATOM   803  C  CA  . ASN A 1 107 ? 11.50643  18.08670  -13.58306 1.000 48.87614  ? 200 ASN A CA  1 
ATOM   804  C  C   . ASN A 1 107 ? 11.28921  16.70348  -12.99201 1.000 52.83347  ? 200 ASN A C   1 
ATOM   805  O  O   . ASN A 1 107 ? 10.34415  16.01224  -13.38055 1.000 49.32545  ? 200 ASN A O   1 
ATOM   806  C  CB  . ASN A 1 107 ? 10.21292  18.90281  -13.63203 1.000 47.53835  ? 200 ASN A CB  1 
ATOM   807  C  CG  . ASN A 1 107 ? 9.75110   19.37354  -12.26435 1.000 47.64809  ? 200 ASN A CG  1 
ATOM   808  O  OD1 . ASN A 1 107 ? 10.02548  18.73892  -11.25065 1.000 38.88381  ? 200 ASN A OD1 1 
ATOM   809  N  ND2 . ASN A 1 107 ? 9.04216   20.50539  -12.23721 1.000 41.35411  ? 200 ASN A ND2 1 
ATOM   810  N  N   . LEU A 1 108 ? 12.17806  16.29929  -12.07550 1.000 52.62915  ? 201 LEU A N   1 
ATOM   811  C  CA  . LEU A 1 108 ? 12.12652  14.97596  -11.45605 1.000 49.64076  ? 201 LEU A CA  1 
ATOM   812  C  C   . LEU A 1 108 ? 11.00145  14.84388  -10.45572 1.000 46.11917  ? 201 LEU A C   1 
ATOM   813  O  O   . LEU A 1 108 ? 10.74823  13.73939  -9.97115  1.000 45.91528  ? 201 LEU A O   1 
ATOM   814  C  CB  . LEU A 1 108 ? 13.43469  14.66659  -10.73483 1.000 45.05992  ? 201 LEU A CB  1 
ATOM   815  C  CG  . LEU A 1 108 ? 14.66732  15.23849  -11.41513 1.000 71.34000  ? 201 LEU A CG  1 
ATOM   816  C  CD1 . LEU A 1 108 ? 15.82283  15.34914  -10.43071 1.000 80.86321  ? 201 LEU A CD1 1 
ATOM   817  C  CD2 . LEU A 1 108 ? 15.02648  14.37149  -12.61051 1.000 60.41115  ? 201 LEU A CD2 1 
ATOM   818  N  N   . ARG A 1 109 ? 10.35072  15.93598  -10.09998 1.000 51.40650  ? 202 ARG A N   1 
ATOM   819  C  CA  . ARG A 1 109 ? 9.20459   15.83652  -9.22429  1.000 43.17811  ? 202 ARG A CA  1 
ATOM   820  C  C   . ARG A 1 109 ? 7.91140   15.68030  -10.00919 1.000 36.56752  ? 202 ARG A C   1 
ATOM   821  O  O   . ARG A 1 109 ? 6.83728   15.63557  -9.40193  1.000 43.34496  ? 202 ARG A O   1 
ATOM   822  C  CB  . ARG A 1 109 ? 9.17645   17.05464  -8.29525  1.000 40.21359  ? 202 ARG A CB  1 
ATOM   823  C  CG  . ARG A 1 109 ? 10.40136  17.08649  -7.36624  1.000 42.70465  ? 202 ARG A CG  1 
ATOM   824  C  CD  . ARG A 1 109 ? 10.43583  18.32872  -6.47633  1.000 55.58557  ? 202 ARG A CD  1 
ATOM   825  N  N   . ALA A 1 110 ? 7.99546   15.57707  -11.33999 1.000 37.66949  ? 203 ALA A N   1 
ATOM   826  C  CA  . ALA A 1 110 ? 6.80629   15.36688  -12.15633 1.000 39.69732  ? 203 ALA A CA  1 
ATOM   827  C  C   . ALA A 1 110 ? 6.15817   14.03087  -11.82479 1.000 40.86093  ? 203 ALA A C   1 
ATOM   828  O  O   . ALA A 1 110 ? 6.83313   13.00034  -11.73434 1.000 41.57615  ? 203 ALA A O   1 
ATOM   829  C  CB  . ALA A 1 110 ? 7.15992   15.41652  -13.64685 1.000 38.66377  ? 203 ALA A CB  1 
ATOM   830  N  N   . GLU A 1 111 ? 4.84280   14.04894  -11.63956 1.000 40.49285  ? 204 GLU A N   1 
ATOM   831  C  CA  . GLU A 1 111 ? 4.08904   12.84050  -11.35501 1.000 44.80125  ? 204 GLU A CA  1 
ATOM   832  C  C   . GLU A 1 111 ? 3.01455   12.64742  -12.41550 1.000 40.60502  ? 204 GLU A C   1 
ATOM   833  O  O   . GLU A 1 111 ? 2.42793   13.61813  -12.91249 1.000 39.25416  ? 204 GLU A O   1 
ATOM   834  C  CB  . GLU A 1 111 ? 3.48287   12.90200  -9.95549  1.000 50.31353  ? 204 GLU A CB  1 
ATOM   835  C  CG  . GLU A 1 111 ? 4.53617   12.85116  -8.83492  1.000 52.25181  ? 204 GLU A CG  1 
ATOM   836  C  CD  . GLU A 1 111 ? 3.92334   13.02431  -7.45152  1.000 47.61562  ? 204 GLU A CD  1 
ATOM   837  O  OE1 . GLU A 1 111 ? 4.67163   13.34714  -6.50682  1.000 55.73508  ? 204 GLU A OE1 1 
ATOM   838  O  OE2 . GLU A 1 111 ? 2.69067   12.84669  -7.31152  1.000 55.31082  ? 204 GLU A OE2 1 
ATOM   839  N  N   . TYR A 1 112 ? 2.77441   11.39172  -12.77554 1.000 37.16559  ? 205 TYR A N   1 
ATOM   840  C  CA  . TYR A 1 112 ? 1.83732   11.04947  -13.83785 1.000 41.47571  ? 205 TYR A CA  1 
ATOM   841  C  C   . TYR A 1 112 ? 0.69669   10.24161  -13.24234 1.000 35.28053  ? 205 TYR A C   1 
ATOM   842  O  O   . TYR A 1 112 ? 0.93342   9.33360   -12.44318 1.000 41.80150  ? 205 TYR A O   1 
ATOM   843  C  CB  . TYR A 1 112 ? 2.53618   10.27871  -14.95332 1.000 32.49830  ? 205 TYR A CB  1 
ATOM   844  C  CG  . TYR A 1 112 ? 3.55591   11.10189  -15.71530 1.000 34.28312  ? 205 TYR A CG  1 
ATOM   845  C  CD1 . TYR A 1 112 ? 4.84427   11.29501  -15.22221 1.000 34.76805  ? 205 TYR A CD1 1 
ATOM   846  C  CD2 . TYR A 1 112 ? 3.23515   11.68415  -16.92838 1.000 32.01854  ? 205 TYR A CD2 1 
ATOM   847  C  CE1 . TYR A 1 112 ? 5.77685   12.05493  -15.92136 1.000 33.91072  ? 205 TYR A CE1 1 
ATOM   848  C  CE2 . TYR A 1 112 ? 4.16640   12.43402  -17.63252 1.000 35.90736  ? 205 TYR A CE2 1 
ATOM   849  C  CZ  . TYR A 1 112 ? 5.43047   12.61418  -17.12468 1.000 31.27888  ? 205 TYR A CZ  1 
ATOM   850  O  OH  . TYR A 1 112 ? 6.33901   13.36254  -17.83133 1.000 37.41779  ? 205 TYR A OH  1 
ATOM   851  N  N   . LEU A 1 113 ? -0.53463  10.58377  -13.61695 1.000 36.84038  ? 206 LEU A N   1 
ATOM   852  C  CA  . LEU A 1 113 ? -1.72820  10.01481  -13.00831 1.000 37.48351  ? 206 LEU A CA  1 
ATOM   853  C  C   . LEU A 1 113 ? -2.61863  9.37547   -14.06218 1.000 45.07036  ? 206 LEU A C   1 
ATOM   854  O  O   . LEU A 1 113 ? -2.91626  9.98852   -15.09378 1.000 41.81161  ? 206 LEU A O   1 
ATOM   855  C  CB  . LEU A 1 113 ? -2.51944  11.07217  -12.23403 1.000 35.15974  ? 206 LEU A CB  1 
ATOM   856  C  CG  . LEU A 1 113 ? -3.88826  10.64876  -11.68938 1.000 37.68975  ? 206 LEU A CG  1 
ATOM   857  C  CD1 . LEU A 1 113 ? -3.71588  9.75003   -10.47174 1.000 42.38437  ? 206 LEU A CD1 1 
ATOM   858  C  CD2 . LEU A 1 113 ? -4.74083  11.86223  -11.33485 1.000 44.01872  ? 206 LEU A CD2 1 
ATOM   859  N  N   . ASP A 1 114 ? -3.02779  8.13650   -13.79235 1.000 39.95582  ? 207 ASP A N   1 
ATOM   860  C  CA  . ASP A 1 114 ? -4.09147  7.43469   -14.50564 1.000 50.20903  ? 207 ASP A CA  1 
ATOM   861  C  C   . ASP A 1 114 ? -5.28766  7.42064   -13.56710 1.000 48.61283  ? 207 ASP A C   1 
ATOM   862  O  O   . ASP A 1 114 ? -5.31390  6.63603   -12.61727 1.000 54.05254  ? 207 ASP A O   1 
ATOM   863  C  CB  . ASP A 1 114 ? -3.68476  6.00326   -14.85231 1.000 51.81298  ? 207 ASP A CB  1 
ATOM   864  C  CG  . ASP A 1 114 ? -2.80353  5.92107   -16.06185 1.000 58.82028  ? 207 ASP A CG  1 
ATOM   865  O  OD1 . ASP A 1 114 ? -1.61411  6.27407   -15.94314 1.000 66.59910  ? 207 ASP A OD1 1 
ATOM   866  O  OD2 . ASP A 1 114 ? -3.29917  5.48696   -17.12483 1.000 66.77868  ? 207 ASP A OD2 1 
ATOM   867  N  N   . ASP A 1 115 ? -6.27199  8.27640   -13.82930 1.000 44.52961  ? 208 ASP A N   1 
ATOM   868  C  CA  . ASP A 1 115 ? -7.41607  8.40348   -12.92986 1.000 47.96516  ? 208 ASP A CA  1 
ATOM   869  C  C   . ASP A 1 115 ? -8.19618  7.09014   -12.84667 1.000 43.77022  ? 208 ASP A C   1 
ATOM   870  O  O   . ASP A 1 115 ? -8.55475  6.50041   -13.87176 1.000 49.35801  ? 208 ASP A O   1 
ATOM   871  C  CB  . ASP A 1 115 ? -8.31523  9.53581   -13.41638 1.000 45.77013  ? 208 ASP A CB  1 
ATOM   872  C  CG  . ASP A 1 115 ? -9.34597  9.94937   -12.38643 1.000 59.77401  ? 208 ASP A CG  1 
ATOM   873  O  OD1 . ASP A 1 115 ? -10.32727 9.19204   -12.20632 1.000 58.33946  ? 208 ASP A OD1 1 
ATOM   874  O  OD2 . ASP A 1 115 ? -9.18869  11.03618  -11.77443 1.000 53.00507  ? 208 ASP A OD2 1 
ATOM   875  N  N   . ARG A 1 116 ? -8.45766  6.62453   -11.61880 1.000 49.24167  ? 209 ARG A N   1 
ATOM   876  C  CA  . ARG A 1 116 ? -9.03168  5.28497   -11.46831 1.000 59.49766  ? 209 ARG A CA  1 
ATOM   877  C  C   . ARG A 1 116 ? -10.49402 5.24861   -11.89040 1.000 57.73629  ? 209 ARG A C   1 
ATOM   878  O  O   . ARG A 1 116 ? -10.98696 4.20069   -12.31495 1.000 55.82949  ? 209 ARG A O   1 
ATOM   879  C  CB  . ARG A 1 116 ? -8.88437  4.78093   -10.02745 1.000 50.64543  ? 209 ARG A CB  1 
ATOM   880  C  CG  . ARG A 1 116 ? -9.57519  5.64068   -8.97493  1.000 65.48352  ? 209 ARG A CG  1 
ATOM   881  N  N   . ASN A 1 117 ? -11.19121 6.37879   -11.81433 1.000 58.66095  ? 210 ASN A N   1 
ATOM   882  C  CA  . ASN A 1 117 ? -12.59724 6.45294   -12.19066 1.000 54.19474  ? 210 ASN A CA  1 
ATOM   883  C  C   . ASN A 1 117 ? -12.82086 6.95769   -13.60952 1.000 60.44263  ? 210 ASN A C   1 
ATOM   884  O  O   . ASN A 1 117 ? -13.68497 6.42793   -14.31838 1.000 61.57976  ? 210 ASN A O   1 
ATOM   885  C  CB  . ASN A 1 117 ? -13.34554 7.34677   -11.20123 1.000 59.34406  ? 210 ASN A CB  1 
ATOM   886  C  CG  . ASN A 1 117 ? -13.35221 6.76706   -9.80180  1.000 70.82738  ? 210 ASN A CG  1 
ATOM   887  O  OD1 . ASN A 1 117 ? -12.87603 7.38987   -8.85646  1.000 76.13947  ? 210 ASN A OD1 1 
ATOM   888  N  ND2 . ASN A 1 117 ? -13.88638 5.55685   -9.66553  1.000 65.58094  ? 210 ASN A ND2 1 
ATOM   889  N  N   . THR A 1 118 ? -12.06596 7.96342   -14.05378 1.000 47.71806  ? 211 THR A N   1 
ATOM   890  C  CA  . THR A 1 118 ? -12.27624 8.52097   -15.38322 1.000 51.51730  ? 211 THR A CA  1 
ATOM   891  C  C   . THR A 1 118 ? -11.34768 7.94927   -16.44756 1.000 44.09365  ? 211 THR A C   1 
ATOM   892  O  O   . THR A 1 118 ? -11.63116 8.12483   -17.63666 1.000 49.43351  ? 211 THR A O   1 
ATOM   893  C  CB  . THR A 1 118 ? -12.09637 10.04748  -15.36348 1.000 53.13727  ? 211 THR A CB  1 
ATOM   894  O  OG1 . THR A 1 118 ? -10.70542 10.34522  -15.23595 1.000 48.40773  ? 211 THR A OG1 1 
ATOM   895  C  CG2 . THR A 1 118 ? -12.84204 10.68763  -14.19363 1.000 48.02891  ? 211 THR A CG2 1 
ATOM   896  N  N   . PHE A 1 119 ? -10.23628 7.31934   -16.05288 1.000 42.48760  ? 212 PHE A N   1 
ATOM   897  C  CA  . PHE A 1 119 ? -9.20335  6.77424   -16.94207 1.000 37.56612  ? 212 PHE A CA  1 
ATOM   898  C  C   . PHE A 1 119 ? -8.46665  7.84567   -17.74184 1.000 44.65354  ? 212 PHE A C   1 
ATOM   899  O  O   . PHE A 1 119 ? -7.76718  7.52441   -18.70922 1.000 44.94728  ? 212 PHE A O   1 
ATOM   900  C  CB  . PHE A 1 119 ? -9.76804  5.70705   -17.88257 1.000 52.33976  ? 212 PHE A CB  1 
ATOM   901  C  CG  . PHE A 1 119 ? -10.58431 4.65810   -17.17332 1.000 59.59580  ? 212 PHE A CG  1 
ATOM   902  C  CD1 . PHE A 1 119 ? -10.03805 3.93625   -16.12814 1.000 56.85645  ? 212 PHE A CD1 1 
ATOM   903  C  CD2 . PHE A 1 119 ? -11.90130 4.41614   -17.53647 1.000 61.00293  ? 212 PHE A CD2 1 
ATOM   904  C  CE1 . PHE A 1 119 ? -10.78527 2.97207   -15.46843 1.000 72.26811  ? 212 PHE A CE1 1 
ATOM   905  C  CE2 . PHE A 1 119 ? -12.65475 3.45730   -16.88105 1.000 59.04087  ? 212 PHE A CE2 1 
ATOM   906  C  CZ  . PHE A 1 119 ? -12.09745 2.73559   -15.84836 1.000 61.34604  ? 212 PHE A CZ  1 
ATOM   907  N  N   . ARG A 1 120 ? -8.58585  9.11257   -17.34832 1.000 39.66780  ? 213 ARG A N   1 
ATOM   908  C  CA  . ARG A 1 120 ? -7.88705  10.19219  -18.03646 1.000 45.08311  ? 213 ARG A CA  1 
ATOM   909  C  C   . ARG A 1 120 ? -6.45165  10.31145  -17.54366 1.000 34.94134  ? 213 ARG A C   1 
ATOM   910  O  O   . ARG A 1 120 ? -6.14434  10.05348  -16.37347 1.000 38.75984  ? 213 ARG A O   1 
ATOM   911  C  CB  . ARG A 1 120 ? -8.62282  11.52179  -17.83097 1.000 42.60451  ? 213 ARG A CB  1 
ATOM   912  C  CG  . ARG A 1 120 ? -9.85984  11.59338  -18.69365 1.000 39.18707  ? 213 ARG A CG  1 
ATOM   913  C  CD  . ARG A 1 120 ? -10.57702 12.89519  -18.58826 1.000 46.17148  ? 213 ARG A CD  1 
ATOM   914  N  NE  . ARG A 1 120 ? -11.85649 12.83492  -19.28501 1.000 50.22131  ? 213 ARG A NE  1 
ATOM   915  C  CZ  . ARG A 1 120 ? -12.00225 12.95413  -20.59751 1.000 50.57893  ? 213 ARG A CZ  1 
ATOM   916  N  NH1 . ARG A 1 120 ? -10.96078 13.12747  -21.39873 1.000 47.45767  ? 213 ARG A NH1 1 
ATOM   917  N  NH2 . ARG A 1 120 ? -13.22297 12.90401  -21.11986 1.000 52.17974  ? 213 ARG A NH2 1 
ATOM   918  N  N   . HIS A 1 121 ? -5.56874  10.69684  -18.45443 1.000 34.31947  ? 214 HIS A N   1 
ATOM   919  C  CA  . HIS A 1 121 ? -4.17253  10.92856  -18.11396 1.000 35.44067  ? 214 HIS A CA  1 
ATOM   920  C  C   . HIS A 1 121 ? -3.93473  12.38646  -17.73373 1.000 40.42459  ? 214 HIS A C   1 
ATOM   921  O  O   . HIS A 1 121 ? -4.58454  13.29986  -18.24918 1.000 39.53400  ? 214 HIS A O   1 
ATOM   922  C  CB  . HIS A 1 121 ? -3.27959  10.54220  -19.28699 1.000 41.70224  ? 214 HIS A CB  1 
ATOM   923  C  CG  . HIS A 1 121 ? -3.47746  9.13150   -19.74603 1.000 42.88586  ? 214 HIS A CG  1 
ATOM   924  N  ND1 . HIS A 1 121 ? -3.12859  8.70043   -21.00987 1.000 41.55623  ? 214 HIS A ND1 1 
ATOM   925  C  CD2 . HIS A 1 121 ? -3.99332  8.05108   -19.10626 1.000 44.37596  ? 214 HIS A CD2 1 
ATOM   926  C  CE1 . HIS A 1 121 ? -3.42416  7.41533   -21.12824 1.000 44.55464  ? 214 HIS A CE1 1 
ATOM   927  N  NE2 . HIS A 1 121 ? -3.94285  6.99530   -19.98528 1.000 39.06115  ? 214 HIS A NE2 1 
ATOM   928  N  N   . SER A 1 122 ? -3.00024  12.59756  -16.81133 1.000 35.56276  ? 215 SER A N   1 
ATOM   929  C  CA  . SER A 1 122 ? -2.54307  13.94501  -16.50619 1.000 30.99155  ? 215 SER A CA  1 
ATOM   930  C  C   . SER A 1 122 ? -1.14314  13.86265  -15.92492 1.000 33.36827  ? 215 SER A C   1 
ATOM   931  O  O   . SER A 1 122 ? -0.71888  12.81032  -15.42952 1.000 33.04466  ? 215 SER A O   1 
ATOM   932  C  CB  . SER A 1 122 ? -3.48480  14.64498  -15.53971 1.000 30.02485  ? 215 SER A CB  1 
ATOM   933  O  OG  . SER A 1 122 ? -3.53495  13.94959  -14.30632 1.000 35.69302  ? 215 SER A OG  1 
ATOM   934  N  N   . VAL A 1 123 ? -0.42762  14.98139  -15.99673 1.000 28.49313  ? 216 VAL A N   1 
ATOM   935  C  CA  . VAL A 1 123 ? 0.91531   15.09136  -15.43639 1.000 28.98623  ? 216 VAL A CA  1 
ATOM   936  C  C   . VAL A 1 123 ? 0.96810   16.35576  -14.58845 1.000 38.57775  ? 216 VAL A C   1 
ATOM   937  O  O   . VAL A 1 123 ? 0.47844   17.41041  -15.00803 1.000 41.10852  ? 216 VAL A O   1 
ATOM   938  C  CB  . VAL A 1 123 ? 2.01196   15.09727  -16.52817 1.000 35.74834  ? 216 VAL A CB  1 
ATOM   939  C  CG1 . VAL A 1 123 ? 1.77423   16.17817  -17.61826 1.000 28.20716  ? 216 VAL A CG1 1 
ATOM   940  C  CG2 . VAL A 1 123 ? 3.37348   15.27775  -15.89058 1.000 35.28053  ? 216 VAL A CG2 1 
ATOM   941  N  N   . VAL A 1 124 ? 1.54335   16.24731  -13.39259 1.000 39.81854  ? 217 VAL A N   1 
ATOM   942  C  CA  . VAL A 1 124 ? 1.42322   17.26767  -12.35984 1.000 36.04928  ? 217 VAL A CA  1 
ATOM   943  C  C   . VAL A 1 124 ? 2.79656   17.53380  -11.74499 1.000 37.80672  ? 217 VAL A C   1 
ATOM   944  O  O   . VAL A 1 124 ? 3.58969   16.60614  -11.55121 1.000 37.62202  ? 217 VAL A O   1 
ATOM   945  C  CB  . VAL A 1 124 ? 0.39140   16.82339  -11.29493 1.000 39.10713  ? 217 VAL A CB  1 
ATOM   946  C  CG1 . VAL A 1 124 ? 0.72889   15.43587  -10.73103 1.000 42.30565  ? 217 VAL A CG1 1 
ATOM   947  C  CG2 . VAL A 1 124 ? 0.26956   17.84382  -10.18327 1.000 35.94665  ? 217 VAL A CG2 1 
ATOM   948  N  N   . VAL A 1 125 ? 3.08971   18.80009  -11.45865 1.000 38.10399  ? 218 VAL A N   1 
ATOM   949  C  CA  . VAL A 1 125 ? 4.39308   19.19623  -10.92038 1.000 34.73229  ? 218 VAL A CA  1 
ATOM   950  C  C   . VAL A 1 125 ? 4.17331   20.15746  -9.75927  1.000 37.02672  ? 218 VAL A C   1 
ATOM   951  O  O   . VAL A 1 125 ? 3.12633   20.82075  -9.66954  1.000 36.97617  ? 218 VAL A O   1 
ATOM   952  C  CB  . VAL A 1 125 ? 5.27779   19.86921  -11.99972 1.000 41.36147  ? 218 VAL A CB  1 
ATOM   953  C  CG1 . VAL A 1 125 ? 5.80002   18.85854  -13.00137 1.000 47.84610  ? 218 VAL A CG1 1 
ATOM   954  C  CG2 . VAL A 1 125 ? 4.51628   20.99113  -12.68760 1.000 43.07258  ? 218 VAL A CG2 1 
ATOM   955  N  N   . PRO A 1 126 ? 5.15116   20.27534  -8.85931  1.000 39.76392  ? 219 PRO A N   1 
ATOM   956  C  CA  . PRO A 1 126 ? 5.07878   21.32777  -7.83797  1.000 34.39231  ? 219 PRO A CA  1 
ATOM   957  C  C   . PRO A 1 126 ? 5.12326   22.70834  -8.47832  1.000 41.60885  ? 219 PRO A C   1 
ATOM   958  O  O   . PRO A 1 126 ? 5.94967   22.98083  -9.35138  1.000 41.48335  ? 219 PRO A O   1 
ATOM   959  C  CB  . PRO A 1 126 ? 6.32372   21.07679  -6.98050  1.000 35.89696  ? 219 PRO A CB  1 
ATOM   960  C  CG  . PRO A 1 126 ? 6.67991   19.63156  -7.23918  1.000 37.80423  ? 219 PRO A CG  1 
ATOM   961  C  CD  . PRO A 1 126 ? 6.32967   19.41280  -8.66767  1.000 35.75746  ? 219 PRO A CD  1 
ATOM   962  N  N   . CYS A 1 127 ? 4.22435   23.58403  -8.04132  1.000 36.32031  ? 220 CYS A N   1 
ATOM   963  C  CA  . CYS A 1 127 ? 4.31353   24.97759  -8.44250  1.000 41.54819  ? 220 CYS A CA  1 
ATOM   964  C  C   . CYS A 1 127 ? 5.53811   25.58367  -7.78459  1.000 46.77323  ? 220 CYS A C   1 
ATOM   965  O  O   . CYS A 1 127 ? 5.77665   25.38505  -6.59208  1.000 50.27146  ? 220 CYS A O   1 
ATOM   966  C  CB  . CYS A 1 127 ? 3.05735   25.74913  -8.05074  1.000 42.33384  ? 220 CYS A CB  1 
ATOM   967  S  SG  . CYS A 1 127 ? 2.71344   27.18688  -9.11779  1.000 46.15883  ? 220 CYS A SG  1 
ATOM   968  N  N   . GLU A 1 128 ? 6.32497   26.30001  -8.56428  1.000 45.49280  ? 221 GLU A N   1 
ATOM   969  C  CA  . GLU A 1 128 ? 7.57709   26.83189  -8.07228  1.000 49.71105  ? 221 GLU A CA  1 
ATOM   970  C  C   . GLU A 1 128 ? 7.62188   28.32054  -8.38148  1.000 54.11221  ? 221 GLU A C   1 
ATOM   971  O  O   . GLU A 1 128 ? 6.94311   28.78047  -9.30321  1.000 45.76399  ? 221 GLU A O   1 
ATOM   972  C  CB  . GLU A 1 128 ? 8.76395   26.10148  -8.72151  1.000 49.92202  ? 221 GLU A CB  1 
ATOM   973  C  CG  . GLU A 1 128 ? 9.10889   24.77798  -8.04776  1.000 53.90088  ? 221 GLU A CG  1 
ATOM   974  N  N   . PRO A 1 129 ? 8.36579   29.10077  -7.59910  1.000 53.89828  ? 222 PRO A N   1 
ATOM   975  C  CA  . PRO A 1 129 ? 8.52367   30.52854  -7.88998  1.000 53.56710  ? 222 PRO A CA  1 
ATOM   976  C  C   . PRO A 1 129 ? 9.34455   30.74023  -9.14636  1.000 49.88630  ? 222 PRO A C   1 
ATOM   977  O  O   . PRO A 1 129 ? 10.02993  29.81766  -9.60738  1.000 47.91895  ? 222 PRO A O   1 
ATOM   978  C  CB  . PRO A 1 129 ? 9.26526   31.04892  -6.65290  1.000 59.89464  ? 222 PRO A CB  1 
ATOM   979  C  CG  . PRO A 1 129 ? 10.06345  29.86665  -6.21294  1.000 52.61544  ? 222 PRO A CG  1 
ATOM   980  C  CD  . PRO A 1 129 ? 9.12528   28.71252  -6.39790  1.000 58.34764  ? 222 PRO A CD  1 
ATOM   981  N  N   . PRO A 1 130 ? 9.28948   31.92931  -9.74530  1.000 54.32489  ? 223 PRO A N   1 
ATOM   982  C  CA  . PRO A 1 130 ? 10.12792  32.18460  -10.92585 1.000 59.05839  ? 223 PRO A CA  1 
ATOM   983  C  C   . PRO A 1 130 ? 11.61175  32.01472  -10.61247 1.000 61.35874  ? 223 PRO A C   1 
ATOM   984  O  O   . PRO A 1 130 ? 12.07721  32.33685  -9.51635  1.000 61.19241  ? 223 PRO A O   1 
ATOM   985  C  CB  . PRO A 1 130 ? 9.77943   33.62980  -11.30184 1.000 54.79275  ? 223 PRO A CB  1 
ATOM   986  C  CG  . PRO A 1 130 ? 8.36576   33.81117  -10.79450 1.000 52.26606  ? 223 PRO A CG  1 
ATOM   987  C  CD  . PRO A 1 130 ? 8.31233   33.01391  -9.51384  1.000 53.70938  ? 223 PRO A CD  1 
ATOM   988  N  N   . GLU A 1 131 ? 12.34036  31.45042  -11.57852 1.000 65.91006  ? 224 GLU A N   1 
ATOM   989  C  CA  . GLU A 1 131 ? 13.78813  31.33625  -11.49084 1.000 70.15191  ? 224 GLU A CA  1 
ATOM   990  C  C   . GLU A 1 131 ? 14.41551  32.72985  -11.46121 1.000 71.08082  ? 224 GLU A C   1 
ATOM   991  O  O   . GLU A 1 131 ? 13.75289  33.74242  -11.71192 1.000 78.98701  ? 224 GLU A O   1 
ATOM   992  C  CB  . GLU A 1 131 ? 14.33594  30.52746  -12.66912 1.000 64.24090  ? 224 GLU A CB  1 
ATOM   993  C  CG  . GLU A 1 131 ? 14.23609  29.00630  -12.51277 1.000 66.20802  ? 224 GLU A CG  1 
ATOM   994  N  N   . VAL A 1 132 ? 15.72143  32.76664  -11.16965 1.000 74.39048  ? 225 VAL A N   1 
ATOM   995  C  CA  . VAL A 1 132 ? 16.41255  34.03135  -10.91578 1.000 84.49298  ? 225 VAL A CA  1 
ATOM   996  C  C   . VAL A 1 132 ? 16.30664  34.95345  -12.12330 1.000 82.63920  ? 225 VAL A C   1 
ATOM   997  O  O   . VAL A 1 132 ? 16.57195  34.55320  -13.26603 1.000 80.19836  ? 225 VAL A O   1 
ATOM   998  C  CB  . VAL A 1 132 ? 17.87980  33.77016  -10.54360 1.000 79.27660  ? 225 VAL A CB  1 
ATOM   999  N  N   . GLY A 1 133 ? 15.89250  36.19076  -11.87108 1.000 75.92485  ? 226 GLY A N   1 
ATOM   1000 C  CA  . GLY A 1 133 ? 15.73180  37.16320  -12.93475 1.000 81.65809  ? 226 GLY A CA  1 
ATOM   1001 C  C   . GLY A 1 133 ? 14.63867  36.83899  -13.92852 1.000 86.89527  ? 226 GLY A C   1 
ATOM   1002 O  O   . GLY A 1 133 ? 14.84042  37.00030  -15.13937 1.000 90.16362  ? 226 GLY A O   1 
ATOM   1003 N  N   . SER A 1 134 ? 13.49012  36.36702  -13.45253 1.000 78.26636  ? 227 SER A N   1 
ATOM   1004 C  CA  . SER A 1 134 ? 12.31244  36.23886  -14.29416 1.000 66.55410  ? 227 SER A CA  1 
ATOM   1005 C  C   . SER A 1 134 ? 11.09227  36.62279  -13.47585 1.000 61.28348  ? 227 SER A C   1 
ATOM   1006 O  O   . SER A 1 134 ? 11.14400  36.74646  -12.24767 1.000 67.24364  ? 227 SER A O   1 
ATOM   1007 C  CB  . SER A 1 134 ? 12.16105  34.82953  -14.87964 1.000 72.03237  ? 227 SER A CB  1 
ATOM   1008 O  OG  . SER A 1 134 ? 11.22053  34.82653  -15.94961 1.000 73.20468  ? 227 SER A OG  1 
ATOM   1009 N  N   . ASP A 1 135 ? 9.99208   36.85321  -14.18211 1.000 51.17357  ? 228 ASP A N   1 
ATOM   1010 C  CA  . ASP A 1 135 ? 8.73430   37.21944  -13.55598 1.000 52.63787  ? 228 ASP A CA  1 
ATOM   1011 C  C   . ASP A 1 135 ? 7.65093   36.20036  -13.85422 1.000 55.55622  ? 228 ASP A C   1 
ATOM   1012 O  O   . ASP A 1 135 ? 6.47852   36.42787  -13.52802 1.000 60.17361  ? 228 ASP A O   1 
ATOM   1013 C  CB  . ASP A 1 135 ? 8.30760   38.60323  -14.02925 1.000 64.50085  ? 228 ASP A CB  1 
ATOM   1014 N  N   . CYS A 1 136 ? 8.01551   35.09185  -14.48019 1.000 56.85368  ? 229 CYS A N   1 
ATOM   1015 C  CA  . CYS A 1 136 ? 7.09639   34.00710  -14.74782 1.000 43.59087  ? 229 CYS A CA  1 
ATOM   1016 C  C   . CYS A 1 136 ? 7.75131   32.70228  -14.32638 1.000 53.79075  ? 229 CYS A C   1 
ATOM   1017 O  O   . CYS A 1 136 ? 8.96406   32.52059  -14.47629 1.000 52.09649  ? 229 CYS A O   1 
ATOM   1018 C  CB  . CYS A 1 136 ? 6.72617   33.94976  -16.23030 1.000 48.78202  ? 229 CYS A CB  1 
ATOM   1019 S  SG  . CYS A 1 136 ? 5.55816   35.20002  -16.78486 1.000 70.65121  ? 229 CYS A SG  1 
ATOM   1020 N  N   . THR A 1 137 ? 6.94525   31.80461  -13.78542 1.000 50.01307  ? 230 THR A N   1 
ATOM   1021 C  CA  . THR A 1 137 ? 7.32019   30.40406  -13.71005 1.000 53.56927  ? 230 THR A CA  1 
ATOM   1022 C  C   . THR A 1 137 ? 7.03329   29.74424  -15.05597 1.000 46.97903  ? 230 THR A C   1 
ATOM   1023 O  O   . THR A 1 137 ? 6.00372   30.00895  -15.68536 1.000 44.96564  ? 230 THR A O   1 
ATOM   1024 C  CB  . THR A 1 137 ? 6.53642   29.72426  -12.58366 1.000 49.78741  ? 230 THR A CB  1 
ATOM   1025 O  OG1 . THR A 1 137 ? 6.98868   30.23711  -11.32255 1.000 53.61342  ? 230 THR A OG1 1 
ATOM   1026 C  CG2 . THR A 1 137 ? 6.68821   28.20875  -12.62063 1.000 42.79158  ? 230 THR A CG2 1 
ATOM   1027 N  N   . THR A 1 138 ? 7.95175   28.89364  -15.49957 1.000 49.64660  ? 231 THR A N   1 
ATOM   1028 C  CA  . THR A 1 138 ? 7.86426   28.23286  -16.79322 1.000 44.02679  ? 231 THR A CA  1 
ATOM   1029 C  C   . THR A 1 138 ? 7.84045   26.72431  -16.60223 1.000 43.46329  ? 231 THR A C   1 
ATOM   1030 O  O   . THR A 1 138 ? 8.63608   26.17651  -15.83379 1.000 40.35559  ? 231 THR A O   1 
ATOM   1031 C  CB  . THR A 1 138 ? 9.04306   28.62904  -17.68701 1.000 39.96664  ? 231 THR A CB  1 
ATOM   1032 O  OG1 . THR A 1 138 ? 9.03036   30.05520  -17.87923 1.000 47.77541  ? 231 THR A OG1 1 
ATOM   1033 C  CG2 . THR A 1 138 ? 8.95119   27.93328  -19.05155 1.000 41.71145  ? 231 THR A CG2 1 
ATOM   1034 N  N   . ILE A 1 139 ? 6.93138   26.05727  -17.29905 1.000 38.95313  ? 232 ILE A N   1 
ATOM   1035 C  CA  . ILE A 1 139 ? 6.90884   24.60246  -17.36482 1.000 37.15060  ? 232 ILE A CA  1 
ATOM   1036 C  C   . ILE A 1 139 ? 7.14600   24.20296  -18.81109 1.000 37.92331  ? 232 ILE A C   1 
ATOM   1037 O  O   . ILE A 1 139 ? 6.59071   24.81610  -19.73123 1.000 36.57133  ? 232 ILE A O   1 
ATOM   1038 C  CB  . ILE A 1 139 ? 5.58565   24.01479  -16.84228 1.000 34.12031  ? 232 ILE A CB  1 
ATOM   1039 C  CG1 . ILE A 1 139 ? 5.39520   24.38042  -15.38000 1.000 39.63648  ? 232 ILE A CG1 1 
ATOM   1040 C  CG2 . ILE A 1 139 ? 5.56764   22.48289  -16.98875 1.000 38.69250  ? 232 ILE A CG2 1 
ATOM   1041 C  CD1 . ILE A 1 139 ? 4.04706   23.99868  -14.86966 1.000 39.34084  ? 232 ILE A CD1 1 
ATOM   1042 N  N   . HIS A 1 140 ? 7.99012   23.19440  -19.00982 1.000 35.97080  ? 233 HIS A N   1 
ATOM   1043 C  CA  . HIS A 1 140 ? 8.30476   22.69499  -20.33864 1.000 39.11712  ? 233 HIS A CA  1 
ATOM   1044 C  C   . HIS A 1 140 ? 7.53443   21.40131  -20.56744 1.000 38.07722  ? 233 HIS A C   1 
ATOM   1045 O  O   . HIS A 1 140 ? 7.74503   20.41939  -19.85234 1.000 38.02092  ? 233 HIS A O   1 
ATOM   1046 C  CB  . HIS A 1 140 ? 9.81252   22.47493  -20.48561 1.000 41.38886  ? 233 HIS A CB  1 
ATOM   1047 C  CG  . HIS A 1 140 ? 10.62000  23.73513  -20.39028 1.000 51.15482  ? 233 HIS A CG  1 
ATOM   1048 N  ND1 . HIS A 1 140 ? 10.53681  24.74725  -21.32384 1.000 47.10092  ? 233 HIS A ND1 1 
ATOM   1049 C  CD2 . HIS A 1 140 ? 11.51418  24.15445  -19.46427 1.000 55.85104  ? 233 HIS A CD2 1 
ATOM   1050 C  CE1 . HIS A 1 140 ? 11.36020  25.72381  -20.99110 1.000 41.76096  ? 233 HIS A CE1 1 
ATOM   1051 N  NE2 . HIS A 1 140 ? 11.95597  25.39560  -19.85989 1.000 51.86009  ? 233 HIS A NE2 1 
ATOM   1052 N  N   . TYR A 1 141 ? 6.63487   21.40966  -21.54274 1.000 37.30611  ? 234 TYR A N   1 
ATOM   1053 C  CA  . TYR A 1 141 ? 5.85167   20.23686  -21.90266 1.000 39.21582  ? 234 TYR A CA  1 
ATOM   1054 C  C   . TYR A 1 141 ? 6.37033   19.62281  -23.19861 1.000 40.43472  ? 234 TYR A C   1 
ATOM   1055 O  O   . TYR A 1 141 ? 6.97486   20.30494  -24.02664 1.000 37.23172  ? 234 TYR A O   1 
ATOM   1056 C  CB  . TYR A 1 141 ? 4.37217   20.60210  -22.06605 1.000 35.79007  ? 234 TYR A CB  1 
ATOM   1057 C  CG  . TYR A 1 141 ? 3.70003   20.98675  -20.77721 1.000 34.09966  ? 234 TYR A CG  1 
ATOM   1058 C  CD1 . TYR A 1 141 ? 3.45757   20.03882  -19.79315 1.000 29.98270  ? 234 TYR A CD1 1 
ATOM   1059 C  CD2 . TYR A 1 141 ? 3.32086   22.30835  -20.53188 1.000 33.51442  ? 234 TYR A CD2 1 
ATOM   1060 C  CE1 . TYR A 1 141 ? 2.84304   20.38218  -18.61438 1.000 40.43605  ? 234 TYR A CE1 1 
ATOM   1061 C  CE2 . TYR A 1 141 ? 2.70777   22.66375  -19.35528 1.000 31.82748  ? 234 TYR A CE2 1 
ATOM   1062 C  CZ  . TYR A 1 141 ? 2.48034   21.70684  -18.39737 1.000 35.53899  ? 234 TYR A CZ  1 
ATOM   1063 O  OH  . TYR A 1 141 ? 1.86667   22.04734  -17.22223 1.000 38.71379  ? 234 TYR A OH  1 
ATOM   1064 N  N   . ASN A 1 142 ? 6.13873   18.32235  -23.36037 1.000 33.14357  ? 235 ASN A N   1 
ATOM   1065 C  CA  . ASN A 1 142 ? 6.33232   17.61482  -24.62198 1.000 37.46787  ? 235 ASN A CA  1 
ATOM   1066 C  C   . ASN A 1 142 ? 5.03275   16.93200  -25.00821 1.000 38.70499  ? 235 ASN A C   1 
ATOM   1067 O  O   . ASN A 1 142 ? 4.35721   16.33081  -24.15910 1.000 35.28102  ? 235 ASN A O   1 
ATOM   1068 C  CB  . ASN A 1 142 ? 7.40081   16.49653  -24.54034 1.000 39.06874  ? 235 ASN A CB  1 
ATOM   1069 C  CG  . ASN A 1 142 ? 8.77480   17.00769  -24.18815 1.000 55.27310  ? 235 ASN A CG  1 
ATOM   1070 O  OD1 . ASN A 1 142 ? 9.10457   18.18991  -24.37623 1.000 46.96192  ? 235 ASN A OD1 1 
ATOM   1071 N  ND2 . ASN A 1 142 ? 9.59862   16.10854  -23.65798 1.000 45.34280  ? 235 ASN A ND2 1 
ATOM   1072 N  N   . TYR A 1 143 ? 4.72603   16.95426  -26.29581 1.000 37.74042  ? 236 TYR A N   1 
ATOM   1073 C  CA  . TYR A 1 143 ? 3.61153   16.20212  -26.84198 1.000 31.82379  ? 236 TYR A CA  1 
ATOM   1074 C  C   . TYR A 1 143 ? 4.15755   15.05382  -27.68262 1.000 42.87731  ? 236 TYR A C   1 
ATOM   1075 O  O   . TYR A 1 143 ? 4.99659   15.26956  -28.56894 1.000 47.58533  ? 236 TYR A O   1 
ATOM   1076 C  CB  . TYR A 1 143 ? 2.70012   17.10404  -27.66011 1.000 36.97566  ? 236 TYR A CB  1 
ATOM   1077 C  CG  . TYR A 1 143 ? 1.97940   18.14823  -26.82921 1.000 35.87003  ? 236 TYR A CG  1 
ATOM   1078 C  CD1 . TYR A 1 143 ? 2.58578   19.34486  -26.51049 1.000 34.45715  ? 236 TYR A CD1 1 
ATOM   1079 C  CD2 . TYR A 1 143 ? 0.69904   17.91662  -26.34985 1.000 38.24883  ? 236 TYR A CD2 1 
ATOM   1080 C  CE1 . TYR A 1 143 ? 1.92870   20.30442  -25.72870 1.000 42.39727  ? 236 TYR A CE1 1 
ATOM   1081 C  CE2 . TYR A 1 143 ? 0.03847   18.85515  -25.57645 1.000 35.52377  ? 236 TYR A CE2 1 
ATOM   1082 C  CZ  . TYR A 1 143 ? 0.65403   20.05246  -25.27778 1.000 38.85481  ? 236 TYR A CZ  1 
ATOM   1083 O  OH  . TYR A 1 143 ? -0.00965  20.98374  -24.52039 1.000 43.57020  ? 236 TYR A OH  1 
ATOM   1084 N  N   . MET A 1 144 ? 3.66935   13.84097  -27.41166 1.000 38.06064  ? 237 MET A N   1 
ATOM   1085 C  CA  . MET A 1 144 ? 4.35153   12.60741  -27.79578 1.000 43.29055  ? 237 MET A CA  1 
ATOM   1086 C  C   . MET A 1 144 ? 3.65990   11.86032  -28.94895 1.000 37.91188  ? 237 MET A C   1 
ATOM   1087 O  O   . MET A 1 144 ? 4.08541   10.74967  -29.30210 1.000 45.60911  ? 237 MET A O   1 
ATOM   1088 C  CB  . MET A 1 144 ? 4.44334   11.70402  -26.56651 1.000 40.33038  ? 237 MET A CB  1 
ATOM   1089 C  CG  . MET A 1 144 ? 5.59190   12.01560  -25.59124 1.000 44.70733  ? 237 MET A CG  1 
ATOM   1090 S  SD  . MET A 1 144 ? 7.02946   12.91242  -26.14476 1.000 41.18072  ? 237 MET A SD  1 
ATOM   1091 C  CE  . MET A 1 144 ? 7.96803   11.41741  -26.76113 1.000 52.66561  ? 237 MET A CE  1 
ATOM   1092 N  N   . CYS A 1 145 ? 2.61324   12.44179  -29.54380 1.000 43.09946  ? 238 CYS A N   1 
ATOM   1093 C  CA  . CYS A 1 145 ? 1.83848   11.88295  -30.64552 1.000 39.54905  ? 238 CYS A CA  1 
ATOM   1094 C  C   . CYS A 1 145 ? 1.48681   13.01962  -31.59427 1.000 52.01912  ? 238 CYS A C   1 
ATOM   1095 O  O   . CYS A 1 145 ? 1.18237   14.12603  -31.13486 1.000 46.68869  ? 238 CYS A O   1 
ATOM   1096 C  CB  . CYS A 1 145 ? 0.54394   11.23724  -30.13386 1.000 51.95833  ? 238 CYS A CB  1 
ATOM   1097 S  SG  . CYS A 1 145 ? 0.15503   9.56538   -30.67406 1.000 49.28531  ? 238 CYS A SG  1 
ATOM   1098 N  N   . TYR A 1 146 ? 1.52443   12.75701  -32.90595 1.000 43.16768  ? 239 TYR A N   1 
ATOM   1099 C  CA  . TYR A 1 146 ? 1.00864   13.72758  -33.86464 1.000 46.76027  ? 239 TYR A CA  1 
ATOM   1100 C  C   . TYR A 1 146 ? -0.51317  13.79761  -33.80936 1.000 48.71799  ? 239 TYR A C   1 
ATOM   1101 O  O   . TYR A 1 146 ? -1.19914  12.81185  -33.52191 1.000 51.18192  ? 239 TYR A O   1 
ATOM   1102 C  CB  . TYR A 1 146 ? 1.43141   13.39392  -35.29533 1.000 52.29186  ? 239 TYR A CB  1 
ATOM   1103 C  CG  . TYR A 1 146 ? 2.91382   13.49460  -35.56364 1.000 53.35411  ? 239 TYR A CG  1 
ATOM   1104 C  CD1 . TYR A 1 146 ? 3.54298   14.72817  -35.65211 1.000 47.48893  ? 239 TYR A CD1 1 
ATOM   1105 C  CD2 . TYR A 1 146 ? 3.67450   12.35516  -35.76657 1.000 50.99122  ? 239 TYR A CD2 1 
ATOM   1106 C  CE1 . TYR A 1 146 ? 4.89495   14.82320  -35.90475 1.000 48.16636  ? 239 TYR A CE1 1 
ATOM   1107 C  CE2 . TYR A 1 146 ? 5.02784   12.43805  -36.01938 1.000 53.33763  ? 239 TYR A CE2 1 
ATOM   1108 C  CZ  . TYR A 1 146 ? 5.63181   13.67705  -36.08551 1.000 61.65165  ? 239 TYR A CZ  1 
ATOM   1109 O  OH  . TYR A 1 146 ? 6.98095   13.76510  -36.33562 1.000 66.75240  ? 239 TYR A OH  1 
ATOM   1110 N  N   . SER A 1 147 ? -1.03653  14.98577  -34.11268 1.000 40.04547  ? 240 SER A N   1 
ATOM   1111 C  CA  . SER A 1 147 ? -2.47877  15.20638  -34.17870 1.000 48.76626  ? 240 SER A CA  1 
ATOM   1112 C  C   . SER A 1 147 ? -3.13049  14.36146  -35.25645 1.000 47.30195  ? 240 SER A C   1 
ATOM   1113 O  O   . SER A 1 147 ? -4.33261  14.09678  -35.18438 1.000 47.84084  ? 240 SER A O   1 
ATOM   1114 C  CB  . SER A 1 147 ? -2.77774  16.69456  -34.44452 1.000 40.38333  ? 240 SER A CB  1 
ATOM   1115 O  OG  . SER A 1 147 ? -2.97953  17.40885  -33.23537 1.000 45.97467  ? 240 SER A OG  1 
ATOM   1116 N  N   . SER A 1 148 ? -2.36762  13.93924  -36.25360 1.000 45.98023  ? 241 SER A N   1 
ATOM   1117 C  CA  . SER A 1 148 ? -2.92367  13.16768  -37.34990 1.000 51.80410  ? 241 SER A CA  1 
ATOM   1118 C  C   . SER A 1 148 ? -2.95247  11.66655  -37.08139 1.000 54.15308  ? 241 SER A C   1 
ATOM   1119 O  O   . SER A 1 148 ? -3.63793  10.95074  -37.81825 1.000 64.40308  ? 241 SER A O   1 
ATOM   1120 C  CB  . SER A 1 148 ? -2.13880  13.45932  -38.63382 1.000 50.14012  ? 241 SER A CB  1 
ATOM   1121 O  OG  . SER A 1 148 ? -0.76186  13.17017  -38.46212 1.000 56.72916  ? 241 SER A OG  1 
ATOM   1122 N  N   . CYS A 1 149 ? -2.26513  11.18710  -36.03581 1.000 52.50909  ? 242 CYS A N   1 
ATOM   1123 C  CA  . CYS A 1 149 ? -2.09580  9.75237   -35.77633 1.000 52.53506  ? 242 CYS A CA  1 
ATOM   1124 C  C   . CYS A 1 149 ? -3.43347  9.02025   -35.70420 1.000 50.37748  ? 242 CYS A C   1 
ATOM   1125 O  O   . CYS A 1 149 ? -4.27034  9.30846   -34.84370 1.000 51.14872  ? 242 CYS A O   1 
ATOM   1126 C  CB  . CYS A 1 149 ? -1.32114  9.54509   -34.47056 1.000 36.34969  ? 242 CYS A CB  1 
ATOM   1127 S  SG  . CYS A 1 149 ? 0.47650   9.65946   -34.59856 1.000 46.67875  ? 242 CYS A SG  1 
ATOM   1128 N  N   . MET A 1 150 ? -3.63810  8.08093   -36.62356 1.000 59.06794  ? 243 MET A N   1 
ATOM   1129 C  CA  . MET A 1 150 ? -4.86502  7.29389   -36.62818 1.000 51.15885  ? 243 MET A CA  1 
ATOM   1130 C  C   . MET A 1 150 ? -4.89585  6.36344   -35.41821 1.000 51.07611  ? 243 MET A C   1 
ATOM   1131 O  O   . MET A 1 150 ? -3.85982  5.88355   -34.94449 1.000 46.44051  ? 243 MET A O   1 
ATOM   1132 C  CB  . MET A 1 150 ? -4.97608  6.50405   -37.93031 1.000 64.76810  ? 243 MET A CB  1 
ATOM   1133 C  CG  . MET A 1 150 ? -4.56510  7.34443   -39.15037 1.000 73.75411  ? 243 MET A CG  1 
ATOM   1134 S  SD  . MET A 1 150 ? -5.12644  6.74902   -40.75874 1.000 85.56443  ? 243 MET A SD  1 
ATOM   1135 C  CE  . MET A 1 150 ? -6.63375  5.95033   -40.28077 1.000 62.58750  ? 243 MET A CE  1 
ATOM   1136 N  N   . GLY A 1 151 ? -6.09464  6.15350   -34.87963 1.000 45.47269  ? 244 GLY A N   1 
ATOM   1137 C  CA  . GLY A 1 151 ? -6.22186  5.40748   -33.64779 1.000 47.01659  ? 244 GLY A CA  1 
ATOM   1138 C  C   . GLY A 1 151 ? -5.83442  6.19074   -32.41993 1.000 52.90105  ? 244 GLY A C   1 
ATOM   1139 O  O   . GLY A 1 151 ? -5.80145  5.62561   -31.32193 1.000 48.79017  ? 244 GLY A O   1 
ATOM   1140 N  N   . GLY A 1 152 ? -5.51576  7.46917   -32.57512 1.000 61.59405  ? 245 GLY A N   1 
ATOM   1141 C  CA  . GLY A 1 152 ? -5.29078  8.35094   -31.45441 1.000 52.33898  ? 245 GLY A CA  1 
ATOM   1142 C  C   . GLY A 1 152 ? -6.13929  9.58510   -31.63066 1.000 54.69837  ? 245 GLY A C   1 
ATOM   1143 O  O   . GLY A 1 152 ? -7.37142  9.49450   -31.73037 1.000 49.50969  ? 245 GLY A O   1 
ATOM   1144 N  N   . MET A 1 153 ? -5.47550  10.74403  -31.68208 1.000 50.14435  ? 246 MET A N   1 
ATOM   1145 C  CA  . MET A 1 153 ? -6.18520  11.99369  -31.91715 1.000 51.78459  ? 246 MET A CA  1 
ATOM   1146 C  C   . MET A 1 153 ? -6.89902  11.97304  -33.26164 1.000 50.85235  ? 246 MET A C   1 
ATOM   1147 O  O   . MET A 1 153 ? -8.07130  12.36235  -33.34576 1.000 48.98988  ? 246 MET A O   1 
ATOM   1148 C  CB  . MET A 1 153 ? -5.20761  13.16752  -31.79998 1.000 51.22127  ? 246 MET A CB  1 
ATOM   1149 C  CG  . MET A 1 153 ? -4.75873  13.38774  -30.35848 1.000 43.39369  ? 246 MET A CG  1 
ATOM   1150 S  SD  . MET A 1 153 ? -3.61593  14.75371  -30.03496 1.000 44.79401  ? 246 MET A SD  1 
ATOM   1151 C  CE  . MET A 1 153 ? -2.07503  14.09447  -30.67836 1.000 34.70414  ? 246 MET A CE  1 
ATOM   1152 N  N   . ASN A 1 154 ? -6.22284  11.47470  -34.30652 1.000 52.83621  ? 247 ASN A N   1 
ATOM   1153 C  CA  . ASN A 1 154 ? -6.83955  11.17592  -35.60952 1.000 59.45506  ? 247 ASN A CA  1 
ATOM   1154 C  C   . ASN A 1 154 ? -7.48129  12.42782  -36.21862 1.000 55.73601  ? 247 ASN A C   1 
ATOM   1155 O  O   . ASN A 1 154 ? -8.65630  12.44279  -36.60200 1.000 46.20161  ? 247 ASN A O   1 
ATOM   1156 C  CB  . ASN A 1 154 ? -7.84365  10.01868  -35.47496 1.000 56.11218  ? 247 ASN A CB  1 
ATOM   1157 C  CG  . ASN A 1 154 ? -8.37504  9.51777   -36.81661 1.000 63.58445  ? 247 ASN A CG  1 
ATOM   1158 O  OD1 . ASN A 1 154 ? -7.62730  9.33309   -37.78515 1.000 65.12381  ? 247 ASN A OD1 1 
ATOM   1159 N  ND2 . ASN A 1 154 ? -9.68584  9.30737   -36.87264 1.000 51.27156  ? 247 ASN A ND2 1 
ATOM   1160 N  N   . ARG A 1 155 ? -6.68895  13.50301  -36.27485 1.000 53.73965  ? 248 ARG A N   1 
ATOM   1161 C  CA  . ARG A 1 155 ? -7.06652  14.82326  -36.78643 1.000 45.92970  ? 248 ARG A CA  1 
ATOM   1162 C  C   . ARG A 1 155 ? -8.14944  15.48767  -35.94395 1.000 50.21368  ? 248 ARG A C   1 
ATOM   1163 O  O   . ARG A 1 155 ? -8.72468  16.49798  -36.37002 1.000 60.10214  ? 248 ARG A O   1 
ATOM   1164 C  CB  . ARG A 1 155 ? -7.51176  14.75910  -38.25957 1.000 54.74795  ? 248 ARG A CB  1 
ATOM   1165 C  CG  . ARG A 1 155 ? -6.60277  13.89351  -39.14464 1.000 54.12350  ? 248 ARG A CG  1 
ATOM   1166 C  CD  . ARG A 1 155 ? -6.53277  14.39037  -40.58014 1.000 69.83331  ? 248 ARG A CD  1 
ATOM   1167 N  NE  . ARG A 1 155 ? -5.28398  14.00381  -41.23064 1.000 78.67589  ? 248 ARG A NE  1 
ATOM   1168 C  CZ  . ARG A 1 155 ? -4.29287  14.84386  -41.51180 1.000 86.46023  ? 248 ARG A CZ  1 
ATOM   1169 N  NH1 . ARG A 1 155 ? -4.37027  16.13647  -41.21742 1.000 79.07539  ? 248 ARG A NH1 1 
ATOM   1170 N  NH2 . ARG A 1 155 ? -3.19332  14.37733  -42.09918 1.000 74.96301  ? 248 ARG A NH2 1 
ATOM   1171 N  N   . ARG A 1 156 ? -8.44359  14.96210  -34.75683 1.000 42.21667  ? 249 ARG A N   1 
ATOM   1172 C  CA  . ARG A 1 156 ? -9.36013  15.67852  -33.87983 1.000 46.90074  ? 249 ARG A CA  1 
ATOM   1173 C  C   . ARG A 1 156 ? -8.57853  16.67022  -33.02779 1.000 57.68432  ? 249 ARG A C   1 
ATOM   1174 O  O   . ARG A 1 156 ? -7.57686  16.28850  -32.40310 1.000 54.04878  ? 249 ARG A O   1 
ATOM   1175 C  CB  . ARG A 1 156 ? -10.13600 14.72368  -32.97911 1.000 53.93966  ? 249 ARG A CB  1 
ATOM   1176 C  CG  . ARG A 1 156 ? -11.12118 13.80441  -33.71742 1.000 46.09144  ? 249 ARG A CG  1 
ATOM   1177 C  CD  . ARG A 1 156 ? -11.64511 12.71100  -32.80628 1.000 52.38139  ? 249 ARG A CD  1 
ATOM   1178 N  NE  . ARG A 1 156 ? -10.62722 11.73735  -32.43898 1.000 48.81650  ? 249 ARG A NE  1 
ATOM   1179 C  CZ  . ARG A 1 156 ? -10.81880 10.75843  -31.56430 1.000 56.16725  ? 249 ARG A CZ  1 
ATOM   1180 N  NH1 . ARG A 1 156 ? -11.98336 10.59557  -30.95419 1.000 47.88345  ? 249 ARG A NH1 1 
ATOM   1181 N  NH2 . ARG A 1 156 ? -9.81592  9.92571   -31.29017 1.000 45.50306  ? 249 ARG A NH2 1 
ATOM   1182 N  N   . PRO A 1 157 ? -8.97472  17.93963  -33.01134 1.000 47.85719  ? 250 PRO A N   1 
ATOM   1183 C  CA  . PRO A 1 157 ? -8.27040  18.91895  -32.18293 1.000 52.16246  ? 250 PRO A CA  1 
ATOM   1184 C  C   . PRO A 1 157 ? -8.41971  18.60060  -30.70525 1.000 47.98840  ? 250 PRO A C   1 
ATOM   1185 O  O   . PRO A 1 157 ? -9.42651  18.04497  -30.25562 1.000 47.88926  ? 250 PRO A O   1 
ATOM   1186 C  CB  . PRO A 1 157 ? -8.96117  20.24440  -32.53442 1.000 48.24659  ? 250 PRO A CB  1 
ATOM   1187 C  CG  . PRO A 1 157 ? -10.32882 19.83317  -32.98004 1.000 55.93836  ? 250 PRO A CG  1 
ATOM   1188 C  CD  . PRO A 1 157 ? -10.11900 18.53409  -33.71778 1.000 48.30076  ? 250 PRO A CD  1 
ATOM   1189 N  N   . ILE A 1 158 ? -7.40216  18.97474  -29.94484 1.000 47.35985  ? 251 ILE A N   1 
ATOM   1190 C  CA  . ILE A 1 158 ? -7.41211  18.79609  -28.50481 1.000 39.83092  ? 251 ILE A CA  1 
ATOM   1191 C  C   . ILE A 1 158 ? -7.15074  20.13154  -27.81897 1.000 40.13065  ? 251 ILE A C   1 
ATOM   1192 O  O   . ILE A 1 158 ? -6.50573  21.02561  -28.37485 1.000 45.32623  ? 251 ILE A O   1 
ATOM   1193 C  CB  . ILE A 1 158 ? -6.37869  17.74023  -28.06240 1.000 44.64258  ? 251 ILE A CB  1 
ATOM   1194 C  CG1 . ILE A 1 158 ? -4.97372  18.18507  -28.46849 1.000 41.11619  ? 251 ILE A CG1 1 
ATOM   1195 C  CG2 . ILE A 1 158 ? -6.73853  16.31649  -28.61420 1.000 37.17569  ? 251 ILE A CG2 1 
ATOM   1196 C  CD1 . ILE A 1 158 ? -3.85045  17.56095  -27.61861 1.000 38.12724  ? 251 ILE A CD1 1 
ATOM   1197 N  N   . LEU A 1 159 ? -7.68204  20.26747  -26.61044 1.000 43.89395  ? 252 LEU A N   1 
ATOM   1198 C  CA  . LEU A 1 159 ? -7.32378  21.33859  -25.69397 1.000 42.71095  ? 252 LEU A CA  1 
ATOM   1199 C  C   . LEU A 1 159 ? -6.39561  20.78829  -24.63207 1.000 43.74050  ? 252 LEU A C   1 
ATOM   1200 O  O   . LEU A 1 159 ? -6.58382  19.66744  -24.16026 1.000 36.85933  ? 252 LEU A O   1 
ATOM   1201 C  CB  . LEU A 1 159 ? -8.54915  21.92817  -24.99468 1.000 47.27977  ? 252 LEU A CB  1 
ATOM   1202 C  CG  . LEU A 1 159 ? -9.71625  22.37915  -25.86620 1.000 61.50037  ? 252 LEU A CG  1 
ATOM   1203 C  CD1 . LEU A 1 159 ? -10.94371 22.64304  -25.01264 1.000 51.23288  ? 252 LEU A CD1 1 
ATOM   1204 C  CD2 . LEU A 1 159 ? -9.31669  23.61617  -26.63986 1.000 54.53406  ? 252 LEU A CD2 1 
ATOM   1205 N  N   . THR A 1 160 ? -5.41956  21.58229  -24.22737 1.000 36.68788  ? 253 THR A N   1 
ATOM   1206 C  CA  . THR A 1 160 ? -4.67021  21.27871  -23.02160 1.000 35.29407  ? 253 THR A CA  1 
ATOM   1207 C  C   . THR A 1 160 ? -5.21859  22.14430  -21.90012 1.000 41.25137  ? 253 THR A C   1 
ATOM   1208 O  O   . THR A 1 160 ? -5.30609  23.36537  -22.04475 1.000 33.75212  ? 253 THR A O   1 
ATOM   1209 C  CB  . THR A 1 160 ? -3.17471  21.51944  -23.21310 1.000 34.58987  ? 253 THR A CB  1 
ATOM   1210 O  OG1 . THR A 1 160 ? -2.66985  20.58702  -24.18533 1.000 36.74591  ? 253 THR A OG1 1 
ATOM   1211 C  CG2 . THR A 1 160 ? -2.45813  21.30130  -21.89685 1.000 35.06989  ? 253 THR A CG2 1 
ATOM   1212 N  N   . ILE A 1 161 ? -5.62131  21.51634  -20.80211 1.000 34.31443  ? 254 ILE A N   1 
ATOM   1213 C  CA  . ILE A 1 161 ? -6.12550  22.23465  -19.63886 1.000 32.78610  ? 254 ILE A CA  1 
ATOM   1214 C  C   . ILE A 1 161 ? -5.05916  22.19422  -18.56171 1.000 35.00671  ? 254 ILE A C   1 
ATOM   1215 O  O   . ILE A 1 161 ? -4.56118  21.11669  -18.21427 1.000 34.95947  ? 254 ILE A O   1 
ATOM   1216 C  CB  . ILE A 1 161 ? -7.44011  21.63792  -19.12197 1.000 42.59068  ? 254 ILE A CB  1 
ATOM   1217 C  CG1 . ILE A 1 161 ? -8.54657  21.86106  -20.14341 1.000 46.64788  ? 254 ILE A CG1 1 
ATOM   1218 C  CG2 . ILE A 1 161 ? -7.80614  22.23821  -17.78505 1.000 38.59992  ? 254 ILE A CG2 1 
ATOM   1219 C  CD1 . ILE A 1 161 ? -9.37817  20.65245  -20.32552 1.000 45.47410  ? 254 ILE A CD1 1 
ATOM   1220 N  N   . ILE A 1 162 ? -4.69492  23.36868  -18.06413 1.000 32.59762  ? 255 ILE A N   1 
ATOM   1221 C  CA  . ILE A 1 162 ? -3.72022  23.53804  -17.00251 1.000 32.57791  ? 255 ILE A CA  1 
ATOM   1222 C  C   . ILE A 1 162 ? -4.47951  23.97821  -15.77089 1.000 39.62776  ? 255 ILE A C   1 
ATOM   1223 O  O   . ILE A 1 162 ? -5.18890  24.98836  -15.80577 1.000 38.73486  ? 255 ILE A O   1 
ATOM   1224 C  CB  . ILE A 1 162 ? -2.67138  24.58608  -17.37938 1.000 33.91970  ? 255 ILE A CB  1 
ATOM   1225 C  CG1 . ILE A 1 162 ? -2.10937  24.29037  -18.76170 1.000 31.56983  ? 255 ILE A CG1 1 
ATOM   1226 C  CG2 . ILE A 1 162 ? -1.57861  24.63589  -16.34725 1.000 35.12393  ? 255 ILE A CG2 1 
ATOM   1227 C  CD1 . ILE A 1 162 ? -1.28181  23.04877  -18.78407 1.000 37.92207  ? 255 ILE A CD1 1 
ATOM   1228 N  N   A THR A 1 163 ? -4.36916  23.22007  -14.68408 0.500 40.23061  ? 256 THR A N   1 
ATOM   1229 N  N   B THR A 1 163 ? -4.31761  23.24498  -14.67882 0.500 40.23185  ? 256 THR A N   1 
ATOM   1230 C  CA  A THR A 1 163 ? -5.06089  23.57205  -13.44955 0.500 38.01441  ? 256 THR A CA  1 
ATOM   1231 C  CA  B THR A 1 163 ? -5.03044  23.54134  -13.44707 0.500 38.02628  ? 256 THR A CA  1 
ATOM   1232 C  C   A THR A 1 163 ? -4.05101  23.78888  -12.33246 0.500 40.31239  ? 256 THR A C   1 
ATOM   1233 C  C   B THR A 1 163 ? -4.03264  23.78762  -12.32565 0.500 40.29698  ? 256 THR A C   1 
ATOM   1234 O  O   A THR A 1 163 ? -3.13417  22.98052  -12.14717 0.500 39.03219  ? 256 THR A O   1 
ATOM   1235 O  O   B THR A 1 163 ? -3.10404  22.99537  -12.12848 0.500 39.03172  ? 256 THR A O   1 
ATOM   1236 C  CB  A THR A 1 163 ? -6.09068  22.50609  -13.04483 0.500 38.24439  ? 256 THR A CB  1 
ATOM   1237 C  CB  B THR A 1 163 ? -5.97604  22.39717  -13.08832 0.500 38.24675  ? 256 THR A CB  1 
ATOM   1238 O  OG1 A THR A 1 163 ? -5.48971  21.20457  -13.02969 0.500 37.79165  ? 256 THR A OG1 1 
ATOM   1239 O  OG1 B THR A 1 163 ? -6.99281  22.29608  -14.09142 0.500 41.71304  ? 256 THR A OG1 1 
ATOM   1240 C  CG2 A THR A 1 163 ? -7.25858  22.51040  -14.01540 0.500 41.38673  ? 256 THR A CG2 1 
ATOM   1241 C  CG2 B THR A 1 163 ? -6.62562  22.65782  -11.76153 0.500 41.17149  ? 256 THR A CG2 1 
ATOM   1242 N  N   . LEU A 1 164 ? -4.21332  24.89758  -11.61549 1.000 35.90787  ? 257 LEU A N   1 
ATOM   1243 C  CA  . LEU A 1 164 ? -3.49062  25.16384  -10.38232 1.000 38.23387  ? 257 LEU A CA  1 
ATOM   1244 C  C   . LEU A 1 164 ? -4.28412  24.53758  -9.23957  1.000 35.17496  ? 257 LEU A C   1 
ATOM   1245 O  O   . LEU A 1 164 ? -5.49289  24.76003  -9.13457  1.000 41.90046  ? 257 LEU A O   1 
ATOM   1246 C  CB  . LEU A 1 164 ? -3.33485  26.67679  -10.18449 1.000 38.04524  ? 257 LEU A CB  1 
ATOM   1247 C  CG  . LEU A 1 164 ? -2.37927  27.19996  -9.11245  1.000 38.81604  ? 257 LEU A CG  1 
ATOM   1248 C  CD1 . LEU A 1 164 ? -0.93214  27.03565  -9.53987  1.000 38.81618  ? 257 LEU A CD1 1 
ATOM   1249 C  CD2 . LEU A 1 164 ? -2.67490  28.65724  -8.76916  1.000 39.71717  ? 257 LEU A CD2 1 
ATOM   1250 N  N   . GLU A 1 165 ? -3.62490  23.70572  -8.42577  1.000 39.18071  ? 258 GLU A N   1 
ATOM   1251 C  CA  . GLU A 1 165 ? -4.29827  22.91089  -7.39831  1.000 40.07407  ? 258 GLU A CA  1 
ATOM   1252 C  C   . GLU A 1 165 ? -3.62624  23.05111  -6.04776  1.000 35.80296  ? 258 GLU A C   1 
ATOM   1253 O  O   . GLU A 1 165 ? -2.40108  23.14702  -5.95461  1.000 37.86877  ? 258 GLU A O   1 
ATOM   1254 C  CB  . GLU A 1 165 ? -4.29347  21.39962  -7.69972  1.000 36.42575  ? 258 GLU A CB  1 
ATOM   1255 C  CG  . GLU A 1 165 ? -4.83535  21.02062  -9.03087  1.000 43.87359  ? 258 GLU A CG  1 
ATOM   1256 C  CD  . GLU A 1 165 ? -4.62708  19.55831  -9.32764  1.000 46.58939  ? 258 GLU A CD  1 
ATOM   1257 O  OE1 . GLU A 1 165 ? -3.83590  18.89151  -8.60184  1.000 44.01654  ? 258 GLU A OE1 1 
ATOM   1258 O  OE2 . GLU A 1 165 ? -5.25473  19.07988  -10.29261 1.000 51.79741  ? 258 GLU A OE2 1 
ATOM   1259 N  N   . ASP A 1 166 ? -4.41785  22.92060  -4.99097  1.000 38.18450  ? 259 ASP A N   1 
ATOM   1260 C  CA  . ASP A 1 166 ? -3.79069  22.81271  -3.68234  1.000 41.47091  ? 259 ASP A CA  1 
ATOM   1261 C  C   . ASP A 1 166 ? -3.20120  21.41616  -3.49037  1.000 39.12731  ? 259 ASP A C   1 
ATOM   1262 O  O   . ASP A 1 166 ? -3.32178  20.53764  -4.34937  1.000 43.21285  ? 259 ASP A O   1 
ATOM   1263 C  CB  . ASP A 1 166 ? -4.77659  23.18238  -2.57634  1.000 45.11767  ? 259 ASP A CB  1 
ATOM   1264 C  CG  . ASP A 1 166 ? -5.96386  22.23234  -2.46852  1.000 50.64895  ? 259 ASP A CG  1 
ATOM   1265 O  OD1 . ASP A 1 166 ? -5.97177  21.11299  -3.04041  1.000 51.47057  ? 259 ASP A OD1 1 
ATOM   1266 O  OD2 . ASP A 1 166 ? -6.92071  22.63027  -1.77533  1.000 48.44950  ? 259 ASP A OD2 1 
ATOM   1267 N  N   . SER A 1 167 ? -2.58208  21.20253  -2.32967  1.000 37.72486  ? 260 SER A N   1 
ATOM   1268 C  CA  . SER A 1 167 ? -1.93789  19.92683  -2.04104  1.000 39.56145  ? 260 SER A CA  1 
ATOM   1269 C  C   . SER A 1 167 ? -2.91092  18.75053  -2.03576  1.000 41.64412  ? 260 SER A C   1 
ATOM   1270 O  O   . SER A 1 167 ? -2.47414  17.61459  -2.22353  1.000 37.97087  ? 260 SER A O   1 
ATOM   1271 C  CB  . SER A 1 167 ? -1.21758  20.00135  -0.69322  1.000 39.78088  ? 260 SER A CB  1 
ATOM   1272 O  OG  . SER A 1 167 ? -2.14853  20.21724  0.35158   1.000 38.69030  ? 260 SER A OG  1 
ATOM   1273 N  N   . SER A 1 168 ? -4.20709  18.98593  -1.83324  1.000 42.64889  ? 261 SER A N   1 
ATOM   1274 C  CA  . SER A 1 168 ? -5.20793  17.92832  -1.92266  1.000 42.13523  ? 261 SER A CA  1 
ATOM   1275 C  C   . SER A 1 168 ? -5.77125  17.75525  -3.32038  1.000 41.13218  ? 261 SER A C   1 
ATOM   1276 O  O   . SER A 1 168 ? -6.58059  16.84723  -3.53844  1.000 47.20167  ? 261 SER A O   1 
ATOM   1277 C  CB  . SER A 1 168 ? -6.37590  18.19388  -0.96924  1.000 40.23649  ? 261 SER A CB  1 
ATOM   1278 O  OG  . SER A 1 168 ? -6.00544  18.01621  0.38155   1.000 48.58942  ? 261 SER A OG  1 
ATOM   1279 N  N   . GLY A 1 169 ? -5.38438  18.59667  -4.26435  1.000 42.30706  ? 262 GLY A N   1 
ATOM   1280 C  CA  . GLY A 1 169 ? -5.97170  18.53583  -5.58062  1.000 39.05581  ? 262 GLY A CA  1 
ATOM   1281 C  C   . GLY A 1 169 ? -7.24980  19.31756  -5.74551  1.000 40.76472  ? 262 GLY A C   1 
ATOM   1282 O  O   . GLY A 1 169 ? -7.93267  19.13357  -6.75606  1.000 37.06726  ? 262 GLY A O   1 
ATOM   1283 N  N   . ASN A 1 170 ? -7.60115  20.18215  -4.79216  1.000 41.26663  ? 263 ASN A N   1 
ATOM   1284 C  CA  . ASN A 1 170 ? -8.71275  21.09727  -5.01448  1.000 44.72694  ? 263 ASN A CA  1 
ATOM   1285 C  C   . ASN A 1 170 ? -8.31821  22.17347  -6.02741  1.000 45.28409  ? 263 ASN A C   1 
ATOM   1286 O  O   . ASN A 1 170 ? -7.16356  22.60139  -6.10092  1.000 41.35660  ? 263 ASN A O   1 
ATOM   1287 C  CB  . ASN A 1 170 ? -9.16525  21.77486  -3.71213  1.000 44.24949  ? 263 ASN A CB  1 
ATOM   1288 C  CG  . ASN A 1 170 ? -9.65724  20.78416  -2.64908  1.000 48.68565  ? 263 ASN A CG  1 
ATOM   1289 O  OD1 . ASN A 1 170 ? -10.56044 19.99093  -2.89417  1.000 49.89148  ? 263 ASN A OD1 1 
ATOM   1290 N  ND2 . ASN A 1 170 ? -9.08133  20.86455  -1.45097  1.000 47.14793  ? 263 ASN A ND2 1 
ATOM   1291 N  N   . LEU A 1 171 ? -9.30375  22.62242  -6.79625  1.000 41.27932  ? 264 LEU A N   1 
ATOM   1292 C  CA  . LEU A 1 171 ? -9.06572  23.59314  -7.85187  1.000 45.04001  ? 264 LEU A CA  1 
ATOM   1293 C  C   . LEU A 1 171 ? -8.75457  24.96333  -7.26588  1.000 45.95470  ? 264 LEU A C   1 
ATOM   1294 O  O   . LEU A 1 171 ? -9.49183  25.46780  -6.41684  1.000 52.56100  ? 264 LEU A O   1 
ATOM   1295 C  CB  . LEU A 1 171 ? -10.29101 23.66784  -8.75990  1.000 47.40887  ? 264 LEU A CB  1 
ATOM   1296 C  CG  . LEU A 1 171 ? -10.37922 24.84765  -9.72985  1.000 55.37610  ? 264 LEU A CG  1 
ATOM   1297 C  CD1 . LEU A 1 171 ? -9.54030  24.55695  -10.93609 1.000 50.60918  ? 264 LEU A CD1 1 
ATOM   1298 C  CD2 . LEU A 1 171 ? -11.82458 25.08895  -10.14384 1.000 53.92527  ? 264 LEU A CD2 1 
ATOM   1299 N  N   . LEU A 1 172 ? -7.64539  25.55894  -7.71131  1.000 50.67142  ? 265 LEU A N   1 
ATOM   1300 C  CA  . LEU A 1 172 ? -7.30818  26.93634  -7.38711  1.000 37.45277  ? 265 LEU A CA  1 
ATOM   1301 C  C   . LEU A 1 172 ? -7.36324  27.84690  -8.58941  1.000 40.67448  ? 265 LEU A C   1 
ATOM   1302 O  O   . LEU A 1 172 ? -7.33732  29.06774  -8.42155  1.000 45.73122  ? 265 LEU A O   1 
ATOM   1303 C  CB  . LEU A 1 172 ? -5.90018  27.03309  -6.78692  1.000 43.72298  ? 265 LEU A CB  1 
ATOM   1304 C  CG  . LEU A 1 172 ? -5.60248  26.25832  -5.50321  1.000 51.40717  ? 265 LEU A CG  1 
ATOM   1305 C  CD1 . LEU A 1 172 ? -4.15137  26.44446  -5.09602  1.000 36.98742  ? 265 LEU A CD1 1 
ATOM   1306 C  CD2 . LEU A 1 172 ? -6.52551  26.71092  -4.38662  1.000 47.44003  ? 265 LEU A CD2 1 
ATOM   1307 N  N   . GLY A 1 173 ? -7.39827  27.28727  -9.78936  1.000 41.15164  ? 266 GLY A N   1 
ATOM   1308 C  CA  . GLY A 1 173 ? -7.39911  28.09246  -10.99686 1.000 38.48538  ? 266 GLY A CA  1 
ATOM   1309 C  C   . GLY A 1 173 ? -7.26180  27.22894  -12.22408 1.000 42.55419  ? 266 GLY A C   1 
ATOM   1310 O  O   . GLY A 1 173 ? -6.77292  26.10085  -12.12511 1.000 39.09108  ? 266 GLY A O   1 
ATOM   1311 N  N   . ARG A 1 174 ? -7.66771  27.74448  -13.38705 1.000 38.95722  ? 267 ARG A N   1 
ATOM   1312 C  CA  . ARG A 1 174 ? -7.65366  26.95136  -14.60998 1.000 38.80900  ? 267 ARG A CA  1 
ATOM   1313 C  C   . ARG A 1 174 ? -7.54974  27.85405  -15.82906 1.000 38.80410  ? 267 ARG A C   1 
ATOM   1314 O  O   . ARG A 1 174 ? -8.18115  28.90961  -15.88174 1.000 41.94168  ? 267 ARG A O   1 
ATOM   1315 C  CB  . ARG A 1 174 ? -8.91634  26.09921  -14.72002 1.000 39.05119  ? 267 ARG A CB  1 
ATOM   1316 C  CG  . ARG A 1 174 ? -8.97824  25.23888  -15.96505 1.000 45.06305  ? 267 ARG A CG  1 
ATOM   1317 C  CD  . ARG A 1 174 ? -10.35841 24.67149  -16.21435 1.000 49.36821  ? 267 ARG A CD  1 
ATOM   1318 N  NE  . ARG A 1 174 ? -10.89379 23.93606  -15.07451 1.000 50.98967  ? 267 ARG A NE  1 
ATOM   1319 C  CZ  . ARG A 1 174 ? -11.81916 24.39948  -14.24443 1.000 55.02796  ? 267 ARG A CZ  1 
ATOM   1320 N  NH1 . ARG A 1 174 ? -12.29050 25.63464  -14.34824 1.000 55.58965  ? 267 ARG A NH1 1 
ATOM   1321 N  NH2 . ARG A 1 174 ? -12.27582 23.60875  -13.28007 1.000 55.82143  ? 267 ARG A NH2 1 
ATOM   1322 N  N   . ASP A 1 175 ? -6.77882  27.40680  -16.81559 1.000 36.13382  ? 268 ASP A N   1 
ATOM   1323 C  CA  . ASP A 1 175 ? -6.64486  28.05593  -18.11125 1.000 38.50181  ? 268 ASP A CA  1 
ATOM   1324 C  C   . ASP A 1 175 ? -6.45764  26.93922  -19.12703 1.000 41.31950  ? 268 ASP A C   1 
ATOM   1325 O  O   . ASP A 1 175 ? -6.32056  25.76424  -18.76136 1.000 42.96897  ? 268 ASP A O   1 
ATOM   1326 C  CB  . ASP A 1 175 ? -5.48445  29.05806  -18.08877 1.000 40.17991  ? 268 ASP A CB  1 
ATOM   1327 C  CG  . ASP A 1 175 ? -5.55372  30.13091  -19.19859 1.000 44.24387  ? 268 ASP A CG  1 
ATOM   1328 O  OD1 . ASP A 1 175 ? -6.27250  29.96761  -20.20427 1.000 36.58856  ? 268 ASP A OD1 1 
ATOM   1329 O  OD2 . ASP A 1 175 ? -4.85133  31.16830  -19.04791 1.000 47.17410  ? 268 ASP A OD2 1 
ATOM   1330 N  N   . SER A 1 176 ? -6.48773  27.29393  -20.40880 1.000 40.38457  ? 269 SER A N   1 
ATOM   1331 C  CA  . SER A 1 176 ? -6.39697  26.26000  -21.42790 1.000 36.49771  ? 269 SER A CA  1 
ATOM   1332 C  C   . SER A 1 176 ? -6.01474  26.87051  -22.76421 1.000 43.13787  ? 269 SER A C   1 
ATOM   1333 O  O   . SER A 1 176 ? -6.16405  28.07475  -22.99070 1.000 40.03477  ? 269 SER A O   1 
ATOM   1334 C  CB  . SER A 1 176 ? -7.70835  25.48378  -21.56090 1.000 41.81318  ? 269 SER A CB  1 
ATOM   1335 O  OG  . SER A 1 176 ? -8.76330  26.31014  -21.98891 1.000 37.77686  ? 269 SER A OG  1 
ATOM   1336 N  N   . PHE A 1 177 ? -5.52800  26.00904  -23.65159 1.000 39.58783  ? 270 PHE A N   1 
ATOM   1337 C  CA  . PHE A 1 177 ? -5.20627  26.39403  -25.01770 1.000 39.50047  ? 270 PHE A CA  1 
ATOM   1338 C  C   . PHE A 1 177 ? -5.37856  25.17601  -25.91355 1.000 43.42542  ? 270 PHE A C   1 
ATOM   1339 O  O   . PHE A 1 177 ? -5.22123  24.03555  -25.46744 1.000 37.64855  ? 270 PHE A O   1 
ATOM   1340 C  CB  . PHE A 1 177 ? -3.77534  26.94692  -25.13857 1.000 32.14303  ? 270 PHE A CB  1 
ATOM   1341 C  CG  . PHE A 1 177 ? -2.71680  26.04777  -24.52623 1.000 34.31835  ? 270 PHE A CG  1 
ATOM   1342 C  CD1 . PHE A 1 177 ? -2.46359  26.06653  -23.16421 1.000 37.14220  ? 270 PHE A CD1 1 
ATOM   1343 C  CD2 . PHE A 1 177 ? -1.96369  25.20333  -25.32204 1.000 38.86956  ? 270 PHE A CD2 1 
ATOM   1344 C  CE1 . PHE A 1 177 ? -1.48823  25.24702  -22.60268 1.000 31.15467  ? 270 PHE A CE1 1 
ATOM   1345 C  CE2 . PHE A 1 177 ? -0.98105  24.39283  -24.76564 1.000 38.00666  ? 270 PHE A CE2 1 
ATOM   1346 C  CZ  . PHE A 1 177 ? -0.75239  24.42175  -23.40039 1.000 36.23927  ? 270 PHE A CZ  1 
ATOM   1347 N  N   . GLU A 1 178 ? -5.70979  25.42903  -27.17968 1.000 41.00258  ? 271 GLU A N   1 
ATOM   1348 C  CA  . GLU A 1 178 ? -5.79481  24.36821  -28.16955 1.000 39.03346  ? 271 GLU A CA  1 
ATOM   1349 C  C   . GLU A 1 178 ? -4.38836  24.00968  -28.64877 1.000 40.32823  ? 271 GLU A C   1 
ATOM   1350 O  O   . GLU A 1 178 ? -3.45839  24.81609  -28.56726 1.000 35.85668  ? 271 GLU A O   1 
ATOM   1351 C  CB  . GLU A 1 178 ? -6.68759  24.80200  -29.33570 1.000 40.09032  ? 271 GLU A CB  1 
ATOM   1352 C  CG  . GLU A 1 178 ? -6.79868  23.77818  -30.49081 1.000 51.63453  ? 271 GLU A CG  1 
ATOM   1353 C  CD  . GLU A 1 178 ? -7.79700  24.16511  -31.56779 1.000 55.57198  ? 271 GLU A CD  1 
ATOM   1354 O  OE1 . GLU A 1 178 ? -8.66994  25.01198  -31.28785 1.000 59.14725  ? 271 GLU A OE1 1 
ATOM   1355 O  OE2 . GLU A 1 178 ? -7.69111  23.63404  -32.70329 1.000 58.18629  ? 271 GLU A OE2 1 
ATOM   1356 N  N   . VAL A 1 179 ? -4.20989  22.76464  -29.08940 1.000 32.59178  ? 272 VAL A N   1 
ATOM   1357 C  CA  . VAL A 1 179 ? -2.89521  22.25582  -29.47012 1.000 36.30010  ? 272 VAL A CA  1 
ATOM   1358 C  C   . VAL A 1 179 ? -2.98590  21.50829  -30.79333 1.000 41.02923  ? 272 VAL A C   1 
ATOM   1359 O  O   . VAL A 1 179 ? -3.92444  20.73687  -31.02601 1.000 48.27891  ? 272 VAL A O   1 
ATOM   1360 C  CB  . VAL A 1 179 ? -2.30591  21.32874  -28.38696 1.000 37.13041  ? 272 VAL A CB  1 
ATOM   1361 C  CG1 . VAL A 1 179 ? -0.93018  20.82450  -28.80000 1.000 40.26697  ? 272 VAL A CG1 1 
ATOM   1362 C  CG2 . VAL A 1 179 ? -2.20327  22.04440  -27.07650 1.000 34.89801  ? 272 VAL A CG2 1 
ATOM   1363 N  N   . ARG A 1 180 ? -1.98698  21.71367  -31.64641 1.000 42.21502  ? 273 ARG A N   1 
ATOM   1364 C  CA  . ARG A 1 180 ? -1.77431  20.89221  -32.82895 1.000 39.21093  ? 273 ARG A CA  1 
ATOM   1365 C  C   . ARG A 1 180 ? -0.33517  20.41762  -32.84141 1.000 42.90145  ? 273 ARG A C   1 
ATOM   1366 O  O   . ARG A 1 180 ? 0.58662   21.23172  -32.93005 1.000 45.57792  ? 273 ARG A O   1 
ATOM   1367 C  CB  . ARG A 1 180 ? -2.07116  21.68472  -34.10026 1.000 48.53165  ? 273 ARG A CB  1 
ATOM   1368 C  CG  . ARG A 1 180 ? -2.00177  20.86574  -35.34298 1.000 49.67842  ? 273 ARG A CG  1 
ATOM   1369 C  CD  . ARG A 1 180 ? -1.94911  21.76341  -36.55299 1.000 58.90166  ? 273 ARG A CD  1 
ATOM   1370 N  NE  . ARG A 1 180 ? -1.38211  21.04833  -37.68521 1.000 62.83762  ? 273 ARG A NE  1 
ATOM   1371 C  CZ  . ARG A 1 180 ? -2.06832  20.19455  -38.42864 1.000 71.88242  ? 273 ARG A CZ  1 
ATOM   1372 N  NH1 . ARG A 1 180 ? -3.35616  19.97251  -38.21056 1.000 68.64575  ? 273 ARG A NH1 1 
ATOM   1373 N  NH2 . ARG A 1 180 ? -1.44851  19.54412  -39.41029 1.000 67.08183  ? 273 ARG A NH2 1 
ATOM   1374 N  N   . VAL A 1 181 ? -0.14068  19.11010  -32.77566 1.000 43.56422  ? 274 VAL A N   1 
ATOM   1375 C  CA  . VAL A 1 181 ? 1.18354   18.50871  -32.88728 1.000 44.27669  ? 274 VAL A CA  1 
ATOM   1376 C  C   . VAL A 1 181 ? 1.36455   18.07108  -34.33463 1.000 46.02012  ? 274 VAL A C   1 
ATOM   1377 O  O   . VAL A 1 181 ? 0.57772   17.26476  -34.84165 1.000 46.59240  ? 274 VAL A O   1 
ATOM   1378 C  CB  . VAL A 1 181 ? 1.33599   17.32873  -31.91709 1.000 46.35544  ? 274 VAL A CB  1 
ATOM   1379 C  CG1 . VAL A 1 181 ? 2.77818   16.89104  -31.83713 1.000 46.16507  ? 274 VAL A CG1 1 
ATOM   1380 C  CG2 . VAL A 1 181 ? 0.81133   17.73910  -30.55763 1.000 43.77833  ? 274 VAL A CG2 1 
ATOM   1381 N  N   . CYS A 1 182 ? 2.38789   18.60336  -35.00060 1.000 46.59764  ? 275 CYS A N   1 
ATOM   1382 C  CA  . CYS A 1 182 ? 2.51321   18.48047  -36.44608 1.000 49.85378  ? 275 CYS A CA  1 
ATOM   1383 C  C   . CYS A 1 182 ? 3.97717   18.65789  -36.82443 1.000 56.68926  ? 275 CYS A C   1 
ATOM   1384 O  O   . CYS A 1 182 ? 4.80311   19.07577  -36.00990 1.000 54.98740  ? 275 CYS A O   1 
ATOM   1385 C  CB  . CYS A 1 182 ? 1.62157   19.49630  -37.16424 1.000 56.49883  ? 275 CYS A CB  1 
ATOM   1386 S  SG  . CYS A 1 182 ? 1.85273   21.24409  -36.65589 1.000 56.20230  ? 275 CYS A SG  1 
ATOM   1387 N  N   . ALA A 1 183 ? 4.29287   18.32387  -38.07821 1.000 55.01310  ? 276 ALA A N   1 
ATOM   1388 C  CA  . ALA A 1 183 ? 5.68772   18.30554  -38.51411 1.000 55.84120  ? 276 ALA A CA  1 
ATOM   1389 C  C   . ALA A 1 183 ? 6.22427   19.69758  -38.82251 1.000 57.18871  ? 276 ALA A C   1 
ATOM   1390 O  O   . ALA A 1 183 ? 7.39974   19.98714  -38.56219 1.000 52.80102  ? 276 ALA A O   1 
ATOM   1391 C  CB  . ALA A 1 183 ? 5.83800   17.40439  -39.73782 1.000 66.86909  ? 276 ALA A CB  1 
ATOM   1392 N  N   . CYS A 1 184 ? 5.39703   20.56920  -39.38497 1.000 53.62358  ? 277 CYS A N   1 
ATOM   1393 C  CA  . CYS A 1 184 ? 5.82662   21.90664  -39.79462 1.000 66.50004  ? 277 CYS A CA  1 
ATOM   1394 C  C   . CYS A 1 184 ? 4.89315   22.91139  -39.12549 1.000 63.68076  ? 277 CYS A C   1 
ATOM   1395 O  O   . CYS A 1 184 ? 3.92349   23.39076  -39.73659 1.000 58.00116  ? 277 CYS A O   1 
ATOM   1396 C  CB  . CYS A 1 184 ? 5.84961   22.02671  -41.32314 1.000 72.67673  ? 277 CYS A CB  1 
ATOM   1397 S  SG  . CYS A 1 184 ? 7.05778   20.90576  -42.13105 1.000 76.87053  ? 277 CYS A SG  1 
ATOM   1398 N  N   . PRO A 1 185 ? 5.14009   23.22335  -37.84289 1.000 60.72952  ? 278 PRO A N   1 
ATOM   1399 C  CA  . PRO A 1 185 ? 4.21581   24.10576  -37.10535 1.000 53.99505  ? 278 PRO A CA  1 
ATOM   1400 C  C   . PRO A 1 185 ? 4.14492   25.51912  -37.64217 1.000 52.30535  ? 278 PRO A C   1 
ATOM   1401 O  O   . PRO A 1 185 ? 3.04629   26.09681  -37.70120 1.000 46.05547  ? 278 PRO A O   1 
ATOM   1402 C  CB  . PRO A 1 185 ? 4.77623   24.07947  -35.67531 1.000 57.51838  ? 278 PRO A CB  1 
ATOM   1403 C  CG  . PRO A 1 185 ? 6.18914   23.59060  -35.80696 1.000 56.56339  ? 278 PRO A CG  1 
ATOM   1404 C  CD  . PRO A 1 185 ? 6.16405   22.63758  -36.96059 1.000 55.13343  ? 278 PRO A CD  1 
ATOM   1405 N  N   . GLY A 1 186 ? 5.28684   26.09964  -38.02295 1.000 58.05885  ? 279 GLY A N   1 
ATOM   1406 C  CA  . GLY A 1 186 ? 5.26730   27.45265  -38.56028 1.000 57.28089  ? 279 GLY A CA  1 
ATOM   1407 C  C   . GLY A 1 186 ? 4.36269   27.56979  -39.77082 1.000 61.16686  ? 279 GLY A C   1 
ATOM   1408 O  O   . GLY A 1 186 ? 3.52291   28.47277  -39.84715 1.000 60.60338  ? 279 GLY A O   1 
ATOM   1409 N  N   . ARG A 1 187 ? 4.48055   26.61165  -40.70198 1.000 54.63295  ? 280 ARG A N   1 
ATOM   1410 C  CA  . ARG A 1 187 ? 3.63015   26.60275  -41.88889 1.000 57.46793  ? 280 ARG A CA  1 
ATOM   1411 C  C   . ARG A 1 187 ? 2.16616   26.42741  -41.52116 1.000 55.54559  ? 280 ARG A C   1 
ATOM   1412 O  O   . ARG A 1 187 ? 1.29507   27.12183  -42.05924 1.000 56.22451  ? 280 ARG A O   1 
ATOM   1413 C  CB  . ARG A 1 187 ? 4.06762   25.48721  -42.84485 1.000 52.51733  ? 280 ARG A CB  1 
ATOM   1414 N  N   . ASP A 1 188 ? 1.87451   25.49928  -40.60724 1.000 59.39881  ? 281 ASP A N   1 
ATOM   1415 C  CA  . ASP A 1 188 ? 0.48352   25.23318  -40.26322 1.000 54.79173  ? 281 ASP A CA  1 
ATOM   1416 C  C   . ASP A 1 188 ? -0.14995  26.40506  -39.52529 1.000 57.82590  ? 281 ASP A C   1 
ATOM   1417 O  O   . ASP A 1 188 ? -1.35273  26.65341  -39.67900 1.000 57.58025  ? 281 ASP A O   1 
ATOM   1418 C  CB  . ASP A 1 188 ? 0.38436   23.96244  -39.43302 1.000 56.93744  ? 281 ASP A CB  1 
ATOM   1419 C  CG  . ASP A 1 188 ? 0.51921   22.70911  -40.28182 1.000 72.59312  ? 281 ASP A CG  1 
ATOM   1420 O  OD1 . ASP A 1 188 ? 0.01500   22.70720  -41.42506 1.000 65.45088  ? 281 ASP A OD1 1 
ATOM   1421 O  OD2 . ASP A 1 188 ? 1.12455   21.72648  -39.80533 1.000 68.34631  ? 281 ASP A OD2 1 
ATOM   1422 N  N   . ARG A 1 189 ? 0.62932   27.12832  -38.71588 1.000 55.57917  ? 282 ARG A N   1 
ATOM   1423 C  CA  . ARG A 1 189 ? 0.07499   28.28548  -38.02391 1.000 53.38801  ? 282 ARG A CA  1 
ATOM   1424 C  C   . ARG A 1 189 ? -0.29722  29.38561  -39.00960 1.000 56.91349  ? 282 ARG A C   1 
ATOM   1425 O  O   . ARG A 1 189 ? -1.39332  29.95640  -38.92926 1.000 65.10080  ? 282 ARG A O   1 
ATOM   1426 C  CB  . ARG A 1 189 ? 1.06132   28.80520  -36.98164 1.000 45.46301  ? 282 ARG A CB  1 
ATOM   1427 C  CG  . ARG A 1 189 ? 0.52406   30.01670  -36.22854 1.000 53.86040  ? 282 ARG A CG  1 
ATOM   1428 C  CD  . ARG A 1 189 ? 1.56638   30.65861  -35.34470 1.000 45.52465  ? 282 ARG A CD  1 
ATOM   1429 N  NE  . ARG A 1 189 ? 1.13558   31.98815  -34.95635 1.000 47.10828  ? 282 ARG A NE  1 
ATOM   1430 C  CZ  . ARG A 1 189 ? 1.88785   32.86521  -34.31137 1.000 46.65958  ? 282 ARG A CZ  1 
ATOM   1431 N  NH1 . ARG A 1 189 ? 3.09803   32.55307  -33.88475 1.000 44.46014  ? 282 ARG A NH1 1 
ATOM   1432 N  NH2 . ARG A 1 189 ? 1.42011   34.09482  -34.10923 1.000 48.77886  ? 282 ARG A NH2 1 
ATOM   1433 N  N   . ARG A 1 190 ? 0.59757   29.68465  -39.95955 1.000 60.78099  ? 283 ARG A N   1 
ATOM   1434 C  CA  . ARG A 1 190 ? 0.30003   30.70791  -40.96355 1.000 68.75980  ? 283 ARG A CA  1 
ATOM   1435 C  C   . ARG A 1 190 ? -0.92645  30.32805  -41.78341 1.000 60.40674  ? 283 ARG A C   1 
ATOM   1436 O  O   . ARG A 1 190 ? -1.76527  31.18115  -42.09891 1.000 64.70977  ? 283 ARG A O   1 
ATOM   1437 C  CB  . ARG A 1 190 ? 1.51192   30.91724  -41.87352 1.000 62.76558  ? 283 ARG A CB  1 
ATOM   1438 N  N   . THR A 1 191 ? -1.05050  29.03935  -42.10593 1.000 62.30888  ? 284 THR A N   1 
ATOM   1439 C  CA  . THR A 1 191 ? -2.21147  28.51558  -42.81650 1.000 62.21516  ? 284 THR A CA  1 
ATOM   1440 C  C   . THR A 1 191 ? -3.50642  28.80916  -42.07017 1.000 64.80537  ? 284 THR A C   1 
ATOM   1441 O  O   . THR A 1 191 ? -4.41283  29.45638  -42.60617 1.000 66.97503  ? 284 THR A O   1 
ATOM   1442 C  CB  . THR A 1 191 ? -2.03441  27.00784  -43.01357 1.000 62.75318  ? 284 THR A CB  1 
ATOM   1443 O  OG1 . THR A 1 191 ? -1.06566  26.77935  -44.04076 1.000 65.62294  ? 284 THR A OG1 1 
ATOM   1444 C  CG2 . THR A 1 191 ? -3.35329  26.33267  -43.38235 1.000 61.92438  ? 284 THR A CG2 1 
ATOM   1445 N  N   . GLU A 1 192 ? -3.60009  28.36406  -40.81492 1.000 62.11453  ? 285 GLU A N   1 
ATOM   1446 C  CA  . GLU A 1 192 ? -4.85558  28.50525  -40.08483 1.000 61.64914  ? 285 GLU A CA  1 
ATOM   1447 C  C   . GLU A 1 192 ? -5.15678  29.95918  -39.76370 1.000 60.71413  ? 285 GLU A C   1 
ATOM   1448 O  O   . GLU A 1 192 ? -6.33103  30.34173  -39.67844 1.000 65.57220  ? 285 GLU A O   1 
ATOM   1449 C  CB  . GLU A 1 192 ? -4.81244  27.67848  -38.80287 1.000 56.39518  ? 285 GLU A CB  1 
ATOM   1450 C  CG  . GLU A 1 192 ? -4.49865  26.21393  -39.03448 1.000 63.06596  ? 285 GLU A CG  1 
ATOM   1451 C  CD  . GLU A 1 192 ? -5.16010  25.31403  -38.00718 1.000 76.07633  ? 285 GLU A CD  1 
ATOM   1452 O  OE1 . GLU A 1 192 ? -4.64340  24.19341  -37.77691 1.000 69.11934  ? 285 GLU A OE1 1 
ATOM   1453 O  OE2 . GLU A 1 192 ? -6.18935  25.73774  -37.42571 1.000 73.12397  ? 285 GLU A OE2 1 
ATOM   1454 N  N   . GLU A 1 193 ? -4.11680  30.77939  -39.57616 1.000 61.64888  ? 286 GLU A N   1 
ATOM   1455 C  CA  . GLU A 1 193 ? -4.34465  32.19357  -39.29450 1.000 67.08631  ? 286 GLU A CA  1 
ATOM   1456 C  C   . GLU A 1 193 ? -4.93991  32.90883  -40.50418 1.000 69.76641  ? 286 GLU A C   1 
ATOM   1457 O  O   . GLU A 1 193 ? -5.88451  33.69335  -40.35838 1.000 72.28195  ? 286 GLU A O   1 
ATOM   1458 C  CB  . GLU A 1 193 ? -3.04119  32.86019  -38.83079 1.000 59.70106  ? 286 GLU A CB  1 
ATOM   1459 C  CG  . GLU A 1 193 ? -2.82057  32.76845  -37.30629 1.000 55.67893  ? 286 GLU A CG  1 
ATOM   1460 C  CD  . GLU A 1 193 ? -1.47936  33.32417  -36.83478 1.000 61.10540  ? 286 GLU A CD  1 
ATOM   1461 O  OE1 . GLU A 1 193 ? -0.67145  33.76363  -37.68311 1.000 58.75891  ? 286 GLU A OE1 1 
ATOM   1462 O  OE2 . GLU A 1 193 ? -1.23642  33.32422  -35.60290 1.000 57.29503  ? 286 GLU A OE2 1 
ATOM   1463 N  N   . GLU A 1 194 ? -4.42921  32.62835  -41.70904 1.000 69.28397  ? 287 GLU A N   1 
ATOM   1464 C  CA  . GLU A 1 194 ? -4.97982  33.27451  -42.89740 1.000 77.69782  ? 287 GLU A CA  1 
ATOM   1465 C  C   . GLU A 1 194 ? -6.43993  32.88939  -43.10111 1.000 76.68958  ? 287 GLU A C   1 
ATOM   1466 O  O   . GLU A 1 194 ? -7.26369  33.73284  -43.47412 1.000 85.96996  ? 287 GLU A O   1 
ATOM   1467 C  CB  . GLU A 1 194 ? -4.14480  32.92788  -44.13259 1.000 73.24990  ? 287 GLU A CB  1 
ATOM   1468 N  N   . ASN A 1 195 ? -6.78240  31.62820  -42.82376 1.000 70.78547  ? 288 ASN A N   1 
ATOM   1469 C  CA  . ASN A 1 195 ? -8.16867  31.18355  -42.93884 1.000 74.89379  ? 288 ASN A CA  1 
ATOM   1470 C  C   . ASN A 1 195 ? -9.08732  31.97016  -42.01253 1.000 80.50642  ? 288 ASN A C   1 
ATOM   1471 O  O   . ASN A 1 195 ? -10.19213 32.35921  -42.40844 1.000 87.74772  ? 288 ASN A O   1 
ATOM   1472 C  CB  . ASN A 1 195 ? -8.27615  29.68780  -42.63073 1.000 75.35076  ? 288 ASN A CB  1 
ATOM   1473 C  CG  . ASN A 1 195 ? -7.32511  28.84463  -43.46322 1.000 82.46219  ? 288 ASN A CG  1 
ATOM   1474 O  OD1 . ASN A 1 195 ? -6.73847  27.87807  -42.96842 1.000 86.02781  ? 288 ASN A OD1 1 
ATOM   1475 N  ND2 . ASN A 1 195 ? -7.16920  29.20285  -44.73420 1.000 81.89027  ? 288 ASN A ND2 1 
ATOM   1476 N  N   . LEU A 1 196 ? -8.65238  32.21341  -40.77393 1.000 72.65490  ? 289 LEU A N   1 
ATOM   1477 C  CA  . LEU A 1 196 ? -9.50312  32.94451  -39.84204 1.000 77.98493  ? 289 LEU A CA  1 
ATOM   1478 C  C   . LEU A 1 196 ? -9.69203  34.39562  -40.27713 1.000 83.83775  ? 289 LEU A C   1 
ATOM   1479 O  O   . LEU A 1 196 ? -10.72728 35.00053  -39.97274 1.000 83.85830  ? 289 LEU A O   1 
ATOM   1480 C  CB  . LEU A 1 196 ? -8.92610  32.85830  -38.42510 1.000 77.58497  ? 289 LEU A CB  1 
ATOM   1481 C  CG  . LEU A 1 196 ? -9.62904  33.60693  -37.28186 1.000 83.29595  ? 289 LEU A CG  1 
ATOM   1482 C  CD1 . LEU A 1 196 ? -11.03737 33.06605  -37.02739 1.000 79.72969  ? 289 LEU A CD1 1 
ATOM   1483 C  CD2 . LEU A 1 196 ? -8.79395  33.57144  -36.00363 1.000 72.39526  ? 289 LEU A CD2 1 
ATOM   1484 N  N   . ARG A 1 197 ? -8.72350  34.96418  -41.00606 1.000 84.73710  ? 290 ARG A N   1 
ATOM   1485 C  CA  . ARG A 1 197 ? -8.92252  36.28636  -41.59767 1.000 91.45163  ? 290 ARG A CA  1 
ATOM   1486 C  C   . ARG A 1 197 ? -9.94455  36.25663  -42.72989 1.000 91.63551  ? 290 ARG A C   1 
ATOM   1487 O  O   . ARG A 1 197 ? -10.56275 37.28840  -43.00799 1.000 94.89467  ? 290 ARG A O   1 
ATOM   1488 C  CB  . ARG A 1 197 ? -7.59529  36.86374  -42.09641 1.000 77.96468  ? 290 ARG A CB  1 
ATOM   1489 N  N   . LYS A 1 198 ? -10.14582 35.10460  -43.37393 1.000 89.93714  ? 291 LYS A N   1 
ATOM   1490 C  CA  . LYS A 1 198 ? -11.26227 34.92617  -44.29998 1.000 88.53941  ? 291 LYS A CA  1 
ATOM   1491 C  C   . LYS A 1 198 ? -12.57429 34.80944  -43.52594 1.000 86.82769  ? 291 LYS A C   1 
ATOM   1492 O  O   . LYS A 1 198 ? -13.23166 35.81351  -43.24305 1.000 87.55071  ? 291 LYS A O   1 
ATOM   1493 C  CB  . LYS A 1 198 ? -11.05938 33.68715  -45.17622 1.000 65.36297  ? 291 LYS A CB  1 
ATOM   1494 N  N   . SER B 1 2   ? 15.50882  1.07570   -19.57643 1.000 63.49781  ? 95  SER B N   1 
ATOM   1495 C  CA  . SER B 1 2   ? 14.74383  1.37311   -18.36930 1.000 75.05119  ? 95  SER B CA  1 
ATOM   1496 C  C   . SER B 1 2   ? 14.49609  2.87511   -18.20758 1.000 77.95087  ? 95  SER B C   1 
ATOM   1497 O  O   . SER B 1 2   ? 13.45548  3.41153   -18.61482 1.000 68.92258  ? 95  SER B O   1 
ATOM   1498 C  CB  . SER B 1 2   ? 15.47107  0.83571   -17.13116 1.000 70.01513  ? 95  SER B CB  1 
ATOM   1499 N  N   . SER B 1 3   ? 15.46458  3.54626   -17.60020 1.000 69.15581  ? 96  SER B N   1 
ATOM   1500 C  CA  . SER B 1 3   ? 15.35778  4.95965   -17.30010 1.000 61.11714  ? 96  SER B CA  1 
ATOM   1501 C  C   . SER B 1 3   ? 16.33770  5.76187   -18.14706 1.000 66.96251  ? 96  SER B C   1 
ATOM   1502 O  O   . SER B 1 3   ? 17.20764  5.21725   -18.83785 1.000 57.49926  ? 96  SER B O   1 
ATOM   1503 C  CB  . SER B 1 3   ? 15.60583  5.22055   -15.81461 1.000 63.55465  ? 96  SER B CB  1 
ATOM   1504 O  OG  . SER B 1 3   ? 15.49866  6.60740   -15.53605 1.000 73.65266  ? 96  SER B OG  1 
ATOM   1505 N  N   . VAL B 1 4   ? 16.17067  7.07888   -18.08413 1.000 55.80844  ? 97  VAL B N   1 
ATOM   1506 C  CA  . VAL B 1 4   ? 16.96780  8.03120   -18.84140 1.000 49.92439  ? 97  VAL B CA  1 
ATOM   1507 C  C   . VAL B 1 4   ? 17.60427  8.98899   -17.84246 1.000 57.68477  ? 97  VAL B C   1 
ATOM   1508 O  O   . VAL B 1 4   ? 16.89194  9.64024   -17.07245 1.000 54.23604  ? 97  VAL B O   1 
ATOM   1509 C  CB  . VAL B 1 4   ? 16.12494  8.79499   -19.87592 1.000 51.77668  ? 97  VAL B CB  1 
ATOM   1510 C  CG1 . VAL B 1 4   ? 16.97390  9.81814   -20.61520 1.000 55.11592  ? 97  VAL B CG1 1 
ATOM   1511 C  CG2 . VAL B 1 4   ? 15.51049  7.82456   -20.86180 1.000 52.58745  ? 97  VAL B CG2 1 
ATOM   1512 N  N   . PRO B 1 5   ? 18.93065  9.06650   -17.77750 1.000 53.96529  ? 98  PRO B N   1 
ATOM   1513 C  CA  . PRO B 1 5   ? 19.57079  10.06253  -16.91161 1.000 48.94223  ? 98  PRO B CA  1 
ATOM   1514 C  C   . PRO B 1 5   ? 19.19119  11.46798  -17.33613 1.000 48.98014  ? 98  PRO B C   1 
ATOM   1515 O  O   . PRO B 1 5   ? 19.09367  11.77276  -18.52661 1.000 49.15445  ? 98  PRO B O   1 
ATOM   1516 C  CB  . PRO B 1 5   ? 21.06406  9.79928   -17.11526 1.000 49.22841  ? 98  PRO B CB  1 
ATOM   1517 C  CG  . PRO B 1 5   ? 21.11651  8.35183   -17.55502 1.000 53.53324  ? 98  PRO B CG  1 
ATOM   1518 C  CD  . PRO B 1 5   ? 19.91292  8.19343   -18.43150 1.000 53.61317  ? 98  PRO B CD  1 
ATOM   1519 N  N   . SER B 1 6   ? 18.95959  12.32056  -16.34708 1.000 41.76398  ? 99  SER B N   1 
ATOM   1520 C  CA  . SER B 1 6   ? 18.59074  13.69376  -16.63473 1.000 39.59567  ? 99  SER B CA  1 
ATOM   1521 C  C   . SER B 1 6   ? 19.73424  14.43141  -17.31657 1.000 45.33201  ? 99  SER B C   1 
ATOM   1522 O  O   . SER B 1 6   ? 20.90961  14.24316  -16.98275 1.000 42.67918  ? 99  SER B O   1 
ATOM   1523 C  CB  . SER B 1 6   ? 18.21793  14.42150  -15.35001 1.000 48.14788  ? 99  SER B CB  1 
ATOM   1524 O  OG  . SER B 1 6   ? 18.48341  15.80319  -15.50992 1.000 54.91940  ? 99  SER B OG  1 
ATOM   1525 N  N   . GLN B 1 7   ? 19.38043  15.28487  -18.27469 1.000 46.25490  ? 100 GLN B N   1 
ATOM   1526 C  CA  . GLN B 1 7   ? 20.34820  16.12722  -18.96201 1.000 47.28108  ? 100 GLN B CA  1 
ATOM   1527 C  C   . GLN B 1 7   ? 20.14366  17.61106  -18.68169 1.000 46.16808  ? 100 GLN B C   1 
ATOM   1528 O  O   . GLN B 1 7   ? 20.77549  18.44022  -19.33508 1.000 52.10742  ? 100 GLN B O   1 
ATOM   1529 C  CB  . GLN B 1 7   ? 20.28410  15.86821  -20.46453 1.000 51.68119  ? 100 GLN B CB  1 
ATOM   1530 C  CG  . GLN B 1 7   ? 19.05358  16.45903  -21.11478 1.000 55.20314  ? 100 GLN B CG  1 
ATOM   1531 C  CD  . GLN B 1 7   ? 18.85299  15.97381  -22.52739 1.000 60.84064  ? 100 GLN B CD  1 
ATOM   1532 O  OE1 . GLN B 1 7   ? 18.46382  14.82517  -22.74807 1.000 59.69609  ? 100 GLN B OE1 1 
ATOM   1533 N  NE2 . GLN B 1 7   ? 19.10076  16.84609  -23.49514 1.000 51.55688  ? 100 GLN B NE2 1 
ATOM   1534 N  N   . LYS B 1 8   ? 19.27857  17.96713  -17.73119 1.000 49.03261  ? 101 LYS B N   1 
ATOM   1535 C  CA  . LYS B 1 8   ? 18.99639  19.37302  -17.45273 1.000 44.24245  ? 101 LYS B CA  1 
ATOM   1536 C  C   . LYS B 1 8   ? 20.22773  20.05759  -16.87247 1.000 42.05974  ? 101 LYS B C   1 
ATOM   1537 O  O   . LYS B 1 8   ? 20.79058  19.58964  -15.87768 1.000 45.49542  ? 101 LYS B O   1 
ATOM   1538 C  CB  . LYS B 1 8   ? 17.81439  19.49508  -16.48524 1.000 45.46736  ? 101 LYS B CB  1 
ATOM   1539 C  CG  . LYS B 1 8   ? 17.30226  20.91496  -16.25013 1.000 48.58388  ? 101 LYS B CG  1 
ATOM   1540 C  CD  . LYS B 1 8   ? 16.42993  20.99237  -14.99628 1.000 56.29347  ? 101 LYS B CD  1 
ATOM   1541 C  CE  . LYS B 1 8   ? 15.53556  22.23667  -15.00446 1.000 56.64446  ? 101 LYS B CE  1 
ATOM   1542 N  N   . THR B 1 9   ? 20.64009  21.16349  -17.50578 1.000 43.32840  ? 102 THR B N   1 
ATOM   1543 C  CA  . THR B 1 9   ? 21.74712  21.97904  -17.01393 1.000 40.43571  ? 102 THR B CA  1 
ATOM   1544 C  C   . THR B 1 9   ? 21.43456  22.53256  -15.62973 1.000 38.67723  ? 102 THR B C   1 
ATOM   1545 O  O   . THR B 1 9   ? 20.30870  22.94891  -15.35043 1.000 44.48060  ? 102 THR B O   1 
ATOM   1546 C  CB  . THR B 1 9   ? 22.01870  23.13539  -17.97373 1.000 39.48929  ? 102 THR B CB  1 
ATOM   1547 O  OG1 . THR B 1 9   ? 22.23340  22.63761  -19.29510 1.000 41.75039  ? 102 THR B OG1 1 
ATOM   1548 C  CG2 . THR B 1 9   ? 23.24369  23.93967  -17.54487 1.000 38.57696  ? 102 THR B CG2 1 
ATOM   1549 N  N   . TYR B 1 10  ? 22.43990  22.53572  -14.75603 1.000 39.74162  ? 103 TYR B N   1 
ATOM   1550 C  CA  . TYR B 1 10  ? 22.23359  22.95135  -13.37134 1.000 33.76512  ? 103 TYR B CA  1 
ATOM   1551 C  C   . TYR B 1 10  ? 23.58197  23.40779  -12.83136 1.000 40.07418  ? 103 TYR B C   1 
ATOM   1552 O  O   . TYR B 1 10  ? 24.46812  22.58459  -12.61024 1.000 42.25038  ? 103 TYR B O   1 
ATOM   1553 C  CB  . TYR B 1 10  ? 21.65314  21.79987  -12.56614 1.000 48.10298  ? 103 TYR B CB  1 
ATOM   1554 C  CG  . TYR B 1 10  ? 21.58468  21.98517  -11.06819 1.000 47.96671  ? 103 TYR B CG  1 
ATOM   1555 C  CD1 . TYR B 1 10  ? 20.92069  23.06752  -10.49396 1.000 52.22686  ? 103 TYR B CD1 1 
ATOM   1556 C  CD2 . TYR B 1 10  ? 22.15974  21.05410  -10.22752 1.000 48.49773  ? 103 TYR B CD2 1 
ATOM   1557 C  CE1 . TYR B 1 10  ? 20.85493  23.21353  -9.10409  1.000 50.32407  ? 103 TYR B CE1 1 
ATOM   1558 C  CE2 . TYR B 1 10  ? 22.09679  21.17957  -8.85369  1.000 48.97314  ? 103 TYR B CE2 1 
ATOM   1559 C  CZ  . TYR B 1 10  ? 21.44452  22.25560  -8.29594  1.000 53.07965  ? 103 TYR B CZ  1 
ATOM   1560 O  OH  . TYR B 1 10  ? 21.40746  22.35529  -6.92431  1.000 56.08918  ? 103 TYR B OH  1 
ATOM   1561 N  N   . GLN B 1 11  ? 23.75313  24.71420  -12.64835 1.000 42.88335  ? 104 GLN B N   1 
ATOM   1562 C  CA  . GLN B 1 11  ? 25.02634  25.19893  -12.12920 1.000 41.08657  ? 104 GLN B CA  1 
ATOM   1563 C  C   . GLN B 1 11  ? 25.19344  24.84282  -10.65946 1.000 36.53663  ? 104 GLN B C   1 
ATOM   1564 O  O   . GLN B 1 11  ? 26.32363  24.65272  -10.19292 1.000 39.58495  ? 104 GLN B O   1 
ATOM   1565 C  CB  . GLN B 1 11  ? 25.14643  26.71214  -12.34681 1.000 42.28524  ? 104 GLN B CB  1 
ATOM   1566 C  CG  . GLN B 1 11  ? 25.21662  27.10349  -13.83109 1.000 44.18429  ? 104 GLN B CG  1 
ATOM   1567 C  CD  . GLN B 1 11  ? 25.62106  28.55659  -14.05131 1.000 56.83461  ? 104 GLN B CD  1 
ATOM   1568 O  OE1 . GLN B 1 11  ? 25.79802  29.31670  -13.09967 1.000 55.37093  ? 104 GLN B OE1 1 
ATOM   1569 N  NE2 . GLN B 1 11  ? 25.77416  28.94549  -15.31341 1.000 61.18933  ? 104 GLN B NE2 1 
ATOM   1570 N  N   . GLY B 1 12  ? 24.09545  24.75185  -9.91638  1.000 38.71235  ? 105 GLY B N   1 
ATOM   1571 C  CA  . GLY B 1 12  ? 24.16348  24.39403  -8.51267  1.000 38.18294  ? 105 GLY B CA  1 
ATOM   1572 C  C   . GLY B 1 12  ? 24.80267  25.47257  -7.64572  1.000 49.90479  ? 105 GLY B C   1 
ATOM   1573 O  O   . GLY B 1 12  ? 25.16999  26.55742  -8.09326  1.000 42.43770  ? 105 GLY B O   1 
ATOM   1574 N  N   . SER B 1 13  ? 24.96189  25.12924  -6.36475  1.000 41.01710  ? 106 SER B N   1 
ATOM   1575 C  CA  . SER B 1 13  ? 25.50468  26.07474  -5.39372  1.000 52.56308  ? 106 SER B CA  1 
ATOM   1576 C  C   . SER B 1 13  ? 26.92492  26.49506  -5.69511  1.000 51.24536  ? 106 SER B C   1 
ATOM   1577 O  O   . SER B 1 13  ? 27.38651  27.48417  -5.13138  1.000 44.64157  ? 106 SER B O   1 
ATOM   1578 C  CB  . SER B 1 13  ? 25.49628  25.49100  -3.98344  1.000 43.60154  ? 106 SER B CB  1 
ATOM   1579 O  OG  . SER B 1 13  ? 24.36502  24.68773  -3.78372  1.000 48.46850  ? 106 SER B OG  1 
ATOM   1580 N  N   . TYR B 1 14  ? 27.65960  25.75086  -6.50588  1.000 48.53276  ? 107 TYR B N   1 
ATOM   1581 C  CA  . TYR B 1 14  ? 29.04307  26.12123  -6.74297  1.000 43.66751  ? 107 TYR B CA  1 
ATOM   1582 C  C   . TYR B 1 14  ? 29.24494  26.75750  -8.10706  1.000 40.12136  ? 107 TYR B C   1 
ATOM   1583 O  O   . TYR B 1 14  ? 30.38830  27.01263  -8.49382  1.000 46.25365  ? 107 TYR B O   1 
ATOM   1584 C  CB  . TYR B 1 14  ? 29.95787  24.90653  -6.54425  1.000 49.79770  ? 107 TYR B CB  1 
ATOM   1585 C  CG  . TYR B 1 14  ? 29.81037  24.30471  -5.16012  1.000 54.89009  ? 107 TYR B CG  1 
ATOM   1586 C  CD1 . TYR B 1 14  ? 30.53839  24.80134  -4.08089  1.000 54.42829  ? 107 TYR B CD1 1 
ATOM   1587 C  CD2 . TYR B 1 14  ? 28.92975  23.25582  -4.92492  1.000 48.72032  ? 107 TYR B CD2 1 
ATOM   1588 C  CE1 . TYR B 1 14  ? 30.38853  24.26471  -2.81574  1.000 56.47191  ? 107 TYR B CE1 1 
ATOM   1589 C  CE2 . TYR B 1 14  ? 28.77717  22.72074  -3.66787  1.000 47.73739  ? 107 TYR B CE2 1 
ATOM   1590 C  CZ  . TYR B 1 14  ? 29.50736  23.22385  -2.61919  1.000 48.32535  ? 107 TYR B CZ  1 
ATOM   1591 O  OH  . TYR B 1 14  ? 29.34218  22.68000  -1.36904  1.000 57.25082  ? 107 TYR B OH  1 
ATOM   1592 N  N   . GLY B 1 15  ? 28.16270  27.06152  -8.82446  1.000 42.48677  ? 108 GLY B N   1 
ATOM   1593 C  CA  . GLY B 1 15  ? 28.28897  27.68517  -10.13102 1.000 39.64476  ? 108 GLY B CA  1 
ATOM   1594 C  C   . GLY B 1 15  ? 29.05410  26.84318  -11.13822 1.000 47.08453  ? 108 GLY B C   1 
ATOM   1595 O  O   . GLY B 1 15  ? 29.97727  27.34102  -11.78797 1.000 44.57310  ? 108 GLY B O   1 
ATOM   1596 N  N   . PHE B 1 16  ? 28.68946  25.56285  -11.25866 1.000 38.72895  ? 109 PHE B N   1 
ATOM   1597 C  CA  . PHE B 1 16  ? 29.42798  24.60994  -12.08318 1.000 37.50158  ? 109 PHE B CA  1 
ATOM   1598 C  C   . PHE B 1 16  ? 29.05259  24.75686  -13.55611 1.000 38.65799  ? 109 PHE B C   1 
ATOM   1599 O  O   . PHE B 1 16  ? 27.86710  24.80000  -13.89973 1.000 41.91211  ? 109 PHE B O   1 
ATOM   1600 C  CB  . PHE B 1 16  ? 29.13703  23.18968  -11.59380 1.000 40.28744  ? 109 PHE B CB  1 
ATOM   1601 C  CG  . PHE B 1 16  ? 29.76774  22.09784  -12.42504 1.000 39.85506  ? 109 PHE B CG  1 
ATOM   1602 C  CD1 . PHE B 1 16  ? 31.12914  21.86422  -12.36939 1.000 37.52433  ? 109 PHE B CD1 1 
ATOM   1603 C  CD2 . PHE B 1 16  ? 28.98433  21.27906  -13.22600 1.000 36.67149  ? 109 PHE B CD2 1 
ATOM   1604 C  CE1 . PHE B 1 16  ? 31.70334  20.85994  -13.11746 1.000 41.03020  ? 109 PHE B CE1 1 
ATOM   1605 C  CE2 . PHE B 1 16  ? 29.55207  20.26446  -13.97466 1.000 38.98561  ? 109 PHE B CE2 1 
ATOM   1606 C  CZ  . PHE B 1 16  ? 30.90791  20.05066  -13.92347 1.000 40.75069  ? 109 PHE B CZ  1 
ATOM   1607 N  N   . ARG B 1 17  ? 30.06787  24.82544  -14.42215 1.000 34.60957  ? 110 ARG B N   1 
ATOM   1608 C  CA  . ARG B 1 17  ? 29.89432  24.97302  -15.86899 1.000 34.65221  ? 110 ARG B CA  1 
ATOM   1609 C  C   . ARG B 1 17  ? 31.11375  24.39301  -16.57527 1.000 33.76757  ? 110 ARG B C   1 
ATOM   1610 O  O   . ARG B 1 17  ? 32.20793  24.32236  -16.01024 1.000 42.29958  ? 110 ARG B O   1 
ATOM   1611 C  CB  . ARG B 1 17  ? 29.70673  26.44929  -16.27783 1.000 48.81805  ? 110 ARG B CB  1 
ATOM   1612 C  CG  . ARG B 1 17  ? 30.54855  27.42913  -15.43984 1.000 42.06092  ? 110 ARG B CG  1 
ATOM   1613 C  CD  . ARG B 1 17  ? 30.30011  28.90765  -15.76271 1.000 53.13728  ? 110 ARG B CD  1 
ATOM   1614 N  NE  . ARG B 1 17  ? 28.94628  29.34187  -15.43938 1.000 64.15958  ? 110 ARG B NE  1 
ATOM   1615 N  N   . LEU B 1 18  ? 30.92854  23.99813  -17.83000 1.000 38.00766  ? 111 LEU B N   1 
ATOM   1616 C  CA  . LEU B 1 18  ? 32.02341  23.49186  -18.64536 1.000 36.77074  ? 111 LEU B CA  1 
ATOM   1617 C  C   . LEU B 1 18  ? 32.54599  24.57843  -19.57172 1.000 47.35498  ? 111 LEU B C   1 
ATOM   1618 O  O   . LEU B 1 18  ? 31.84480  25.53413  -19.90691 1.000 47.42183  ? 111 LEU B O   1 
ATOM   1619 C  CB  . LEU B 1 18  ? 31.58719  22.28412  -19.48994 1.000 42.10835  ? 111 LEU B CB  1 
ATOM   1620 C  CG  . LEU B 1 18  ? 30.97876  21.10922  -18.74206 1.000 44.53628  ? 111 LEU B CG  1 
ATOM   1621 C  CD1 . LEU B 1 18  ? 30.35400  20.08372  -19.68473 1.000 41.89342  ? 111 LEU B CD1 1 
ATOM   1622 C  CD2 . LEU B 1 18  ? 32.03144  20.47343  -17.86648 1.000 40.02150  ? 111 LEU B CD2 1 
ATOM   1623 N  N   . GLY B 1 19  ? 33.78792  24.40423  -19.99690 1.000 44.78990  ? 112 GLY B N   1 
ATOM   1624 C  CA  . GLY B 1 19  ? 34.38913  25.29622  -20.96521 1.000 38.39938  ? 112 GLY B CA  1 
ATOM   1625 C  C   . GLY B 1 19  ? 35.30079  24.52297  -21.89277 1.000 48.47804  ? 112 GLY B C   1 
ATOM   1626 O  O   . GLY B 1 19  ? 35.85062  23.47920  -21.53355 1.000 50.62335  ? 112 GLY B O   1 
ATOM   1627 N  N   . PHE B 1 20  ? 35.43405  25.04152  -23.10870 1.000 42.26270  ? 113 PHE B N   1 
ATOM   1628 C  CA  . PHE B 1 20  ? 36.32549  24.45607  -24.10050 1.000 42.54565  ? 113 PHE B CA  1 
ATOM   1629 C  C   . PHE B 1 20  ? 37.20023  25.55068  -24.67968 1.000 49.79909  ? 113 PHE B C   1 
ATOM   1630 O  O   . PHE B 1 20  ? 36.70934  26.63468  -25.00537 1.000 48.30866  ? 113 PHE B O   1 
ATOM   1631 C  CB  . PHE B 1 20  ? 35.55437  23.78045  -25.23797 1.000 38.78360  ? 113 PHE B CB  1 
ATOM   1632 C  CG  . PHE B 1 20  ? 34.61360  22.71178  -24.78039 1.000 43.36282  ? 113 PHE B CG  1 
ATOM   1633 C  CD1 . PHE B 1 20  ? 33.34942  23.03503  -24.31476 1.000 46.30952  ? 113 PHE B CD1 1 
ATOM   1634 C  CD2 . PHE B 1 20  ? 34.98970  21.38063  -24.81452 1.000 41.59921  ? 113 PHE B CD2 1 
ATOM   1635 C  CE1 . PHE B 1 20  ? 32.48274  22.04324  -23.88649 1.000 52.27409  ? 113 PHE B CE1 1 
ATOM   1636 C  CE2 . PHE B 1 20  ? 34.12346  20.38460  -24.39802 1.000 39.90365  ? 113 PHE B CE2 1 
ATOM   1637 C  CZ  . PHE B 1 20  ? 32.87115  20.71859  -23.93187 1.000 38.96544  ? 113 PHE B CZ  1 
ATOM   1638 N  N   . LEU B 1 21  ? 38.48351  25.25818  -24.83106 1.000 47.48378  ? 114 LEU B N   1 
ATOM   1639 C  CA  . LEU B 1 21  ? 39.39700  26.20591  -25.44912 1.000 54.55043  ? 114 LEU B CA  1 
ATOM   1640 C  C   . LEU B 1 21  ? 39.22397  26.20143  -26.96891 1.000 63.87036  ? 114 LEU B C   1 
ATOM   1641 O  O   . LEU B 1 21  ? 38.88523  25.17467  -27.56858 1.000 62.93604  ? 114 LEU B O   1 
ATOM   1642 C  CB  . LEU B 1 21  ? 40.83211  25.85973  -25.06081 1.000 54.99533  ? 114 LEU B CB  1 
ATOM   1643 C  CG  . LEU B 1 21  ? 41.14953  26.10981  -23.58444 1.000 51.86752  ? 114 LEU B CG  1 
ATOM   1644 C  CD1 . LEU B 1 21  ? 42.64714  26.25378  -23.40548 1.000 55.38963  ? 114 LEU B CD1 1 
ATOM   1645 C  CD2 . LEU B 1 21  ? 40.41450  27.36570  -23.07127 1.000 56.67183  ? 114 LEU B CD2 1 
ATOM   1646 N  N   . HIS B 1 22  ? 39.43718  27.36911  -27.58698 1.000 62.47348  ? 115 HIS B N   1 
ATOM   1647 C  CA  . HIS B 1 22  ? 39.27454  27.50351  -29.03290 1.000 59.08332  ? 115 HIS B CA  1 
ATOM   1648 C  C   . HIS B 1 22  ? 40.25535  26.59405  -29.76219 1.000 59.74055  ? 115 HIS B C   1 
ATOM   1649 O  O   . HIS B 1 22  ? 41.42917  26.50332  -29.39308 1.000 71.64868  ? 115 HIS B O   1 
ATOM   1650 C  CB  . HIS B 1 22  ? 39.48191  28.96590  -29.47311 1.000 64.50928  ? 115 HIS B CB  1 
ATOM   1651 C  CG  . HIS B 1 22  ? 39.57754  29.14440  -30.96414 1.000 74.13227  ? 115 HIS B CG  1 
ATOM   1652 N  ND1 . HIS B 1 22  ? 38.51186  29.56344  -31.73458 1.000 76.15017  ? 115 HIS B ND1 1 
ATOM   1653 C  CD2 . HIS B 1 22  ? 40.61195  28.96444  -31.82448 1.000 72.38300  ? 115 HIS B CD2 1 
ATOM   1654 C  CE1 . HIS B 1 22  ? 38.88057  29.61920  -33.00339 1.000 76.80061  ? 115 HIS B CE1 1 
ATOM   1655 N  NE2 . HIS B 1 22  ? 40.14917  29.25791  -33.08551 1.000 74.73186  ? 115 HIS B NE2 1 
ATOM   1656 N  N   . SER B 1 23  ? 39.77173  25.91560  -30.80775 1.000 63.91973  ? 116 SER B N   1 
ATOM   1657 C  CA  . SER B 1 23  ? 40.61332  24.92884  -31.48084 1.000 72.90156  ? 116 SER B CA  1 
ATOM   1658 C  C   . SER B 1 23  ? 40.67874  25.11208  -32.99626 1.000 80.58678  ? 116 SER B C   1 
ATOM   1659 O  O   . SER B 1 23  ? 41.71231  24.81212  -33.60732 1.000 84.04180  ? 116 SER B O   1 
ATOM   1660 C  CB  . SER B 1 23  ? 40.13772  23.51151  -31.15500 1.000 67.80272  ? 116 SER B CB  1 
ATOM   1661 O  OG  . SER B 1 23  ? 41.23272  22.60482  -31.16923 1.000 69.01475  ? 116 SER B OG  1 
ATOM   1662 N  N   . GLY B 1 24  ? 39.59112  25.57990  -33.61704 1.000 74.42457  ? 117 GLY B N   1 
ATOM   1663 C  CA  . GLY B 1 24  ? 39.56635  25.75540  -35.05670 1.000 67.14856  ? 117 GLY B CA  1 
ATOM   1664 C  C   . GLY B 1 24  ? 39.27167  24.47337  -35.82474 1.000 78.61567  ? 117 GLY B C   1 
ATOM   1665 O  O   . GLY B 1 24  ? 39.18357  23.37133  -35.27506 1.000 72.24031  ? 117 GLY B O   1 
ATOM   1666 N  N   . THR B 1 25  ? 39.14065  24.62990  -37.14831 1.000 82.24311  ? 118 THR B N   1 
ATOM   1667 C  CA  . THR B 1 25  ? 38.65264  23.57148  -38.03124 1.000 77.53036  ? 118 THR B CA  1 
ATOM   1668 C  C   . THR B 1 25  ? 39.69997  23.07719  -39.03100 1.000 77.29615  ? 118 THR B C   1 
ATOM   1669 O  O   . THR B 1 25  ? 39.33854  22.55474  -40.08984 1.000 72.81926  ? 118 THR B O   1 
ATOM   1670 C  CB  . THR B 1 25  ? 37.41271  24.04330  -38.79059 1.000 72.75726  ? 118 THR B CB  1 
ATOM   1671 O  OG1 . THR B 1 25  ? 37.55027  25.43315  -39.11116 1.000 75.81064  ? 118 THR B OG1 1 
ATOM   1672 C  CG2 . THR B 1 25  ? 36.16243  23.83701  -37.96283 1.000 61.88066  ? 118 THR B CG2 1 
ATOM   1673 N  N   . ALA B 1 26  ? 40.98834  23.22109  -38.71135 1.000 79.10252  ? 119 ALA B N   1 
ATOM   1674 C  CA  . ALA B 1 26  ? 42.04714  22.81524  -39.63159 1.000 73.04163  ? 119 ALA B CA  1 
ATOM   1675 C  C   . ALA B 1 26  ? 42.00712  21.30744  -39.88237 1.000 82.52566  ? 119 ALA B C   1 
ATOM   1676 O  O   . ALA B 1 26  ? 41.51303  20.53075  -39.05867 1.000 77.36472  ? 119 ALA B O   1 
ATOM   1677 C  CB  . ALA B 1 26  ? 43.41324  23.22412  -39.07894 1.000 71.65784  ? 119 ALA B CB  1 
ATOM   1678 N  N   . LYS B 1 27  ? 42.52755  20.89984  -41.04880 1.000 84.99733  ? 120 LYS B N   1 
ATOM   1679 C  CA  . LYS B 1 27  ? 42.42735  19.50551  -41.48052 1.000 84.24888  ? 120 LYS B CA  1 
ATOM   1680 C  C   . LYS B 1 27  ? 43.14085  18.55583  -40.52369 1.000 80.62196  ? 120 LYS B C   1 
ATOM   1681 O  O   . LYS B 1 27  ? 42.74300  17.39080  -40.39209 1.000 81.35524  ? 120 LYS B O   1 
ATOM   1682 C  CB  . LYS B 1 27  ? 42.99346  19.35467  -42.89546 1.000 86.01117  ? 120 LYS B CB  1 
ATOM   1683 N  N   . SER B 1 28  ? 44.17665  19.03799  -39.83653 1.000 71.96995  ? 121 SER B N   1 
ATOM   1684 C  CA  . SER B 1 28  ? 44.92366  18.24615  -38.86947 1.000 74.30786  ? 121 SER B CA  1 
ATOM   1685 C  C   . SER B 1 28  ? 44.47664  18.49239  -37.42644 1.000 78.27263  ? 121 SER B C   1 
ATOM   1686 O  O   . SER B 1 28  ? 45.27116  18.30502  -36.49687 1.000 84.97722  ? 121 SER B O   1 
ATOM   1687 C  CB  . SER B 1 28  ? 46.41978  18.52328  -39.01737 1.000 75.10638  ? 121 SER B CB  1 
ATOM   1688 N  N   . VAL B 1 29  ? 43.23333  18.92005  -37.20571 1.000 76.70477  ? 122 VAL B N   1 
ATOM   1689 C  CA  . VAL B 1 29  ? 42.71409  18.97764  -35.84341 1.000 68.86627  ? 122 VAL B CA  1 
ATOM   1690 C  C   . VAL B 1 29  ? 42.27178  17.57933  -35.43278 1.000 68.82857  ? 122 VAL B C   1 
ATOM   1691 O  O   . VAL B 1 29  ? 41.74141  16.80851  -36.24558 1.000 72.33529  ? 122 VAL B O   1 
ATOM   1692 C  CB  . VAL B 1 29  ? 41.57050  20.00513  -35.71377 1.000 66.62708  ? 122 VAL B CB  1 
ATOM   1693 C  CG1 . VAL B 1 29  ? 40.23815  19.49562  -36.30040 1.000 59.89122  ? 122 VAL B CG1 1 
ATOM   1694 C  CG2 . VAL B 1 29  ? 41.39687  20.40481  -34.25920 1.000 63.04231  ? 122 VAL B CG2 1 
ATOM   1695 N  N   . THR B 1 30  ? 42.54399  17.21583  -34.18277 1.000 53.79697  ? 123 THR B N   1 
ATOM   1696 C  CA  . THR B 1 30  ? 42.03939  15.96248  -33.64519 1.000 58.67012  ? 123 THR B CA  1 
ATOM   1697 C  C   . THR B 1 30  ? 40.84772  16.15471  -32.72520 1.000 58.02274  ? 123 THR B C   1 
ATOM   1698 O  O   . THR B 1 30  ? 40.18265  15.17813  -32.38359 1.000 56.08865  ? 123 THR B O   1 
ATOM   1699 C  CB  . THR B 1 30  ? 43.14635  15.21395  -32.89531 1.000 58.84690  ? 123 THR B CB  1 
ATOM   1700 O  OG1 . THR B 1 30  ? 43.34111  15.79793  -31.60127 1.000 52.07151  ? 123 THR B OG1 1 
ATOM   1701 C  CG2 . THR B 1 30  ? 44.43010  15.28569  -33.67852 1.000 64.18005  ? 123 THR B CG2 1 
ATOM   1702 N  N   . CYS B 1 31  ? 40.55219  17.38594  -32.34061 1.000 61.72868  ? 124 CYS B N   1 
ATOM   1703 C  CA  . CYS B 1 31  ? 39.52867  17.65211  -31.33968 1.000 51.00744  ? 124 CYS B CA  1 
ATOM   1704 C  C   . CYS B 1 31  ? 39.12670  19.10528  -31.49552 1.000 53.63861  ? 124 CYS B C   1 
ATOM   1705 O  O   . CYS B 1 31  ? 39.98465  19.98859  -31.41013 1.000 59.01692  ? 124 CYS B O   1 
ATOM   1706 C  CB  . CYS B 1 31  ? 40.07859  17.38356  -29.94423 1.000 43.85122  ? 124 CYS B CB  1 
ATOM   1707 S  SG  . CYS B 1 31  ? 39.00585  17.82757  -28.59884 1.000 53.55814  ? 124 CYS B SG  1 
ATOM   1708 N  N   . THR B 1 32  ? 37.84660  19.36190  -31.73919 1.000 45.94380  ? 125 THR B N   1 
ATOM   1709 C  CA  . THR B 1 32  ? 37.40659  20.73925  -31.88890 1.000 47.43550  ? 125 THR B CA  1 
ATOM   1710 C  C   . THR B 1 32  ? 35.96926  20.87142  -31.39846 1.000 42.63493  ? 125 THR B C   1 
ATOM   1711 O  O   . THR B 1 32  ? 35.16458  19.94834  -31.55449 1.000 43.53583  ? 125 THR B O   1 
ATOM   1712 C  CB  . THR B 1 32  ? 37.56727  21.19722  -33.35277 1.000 51.62284  ? 125 THR B CB  1 
ATOM   1713 O  OG1 . THR B 1 32  ? 37.38644  22.61568  -33.43951 1.000 51.49728  ? 125 THR B OG1 1 
ATOM   1714 C  CG2 . THR B 1 32  ? 36.59864  20.47818  -34.28969 1.000 47.76020  ? 125 THR B CG2 1 
ATOM   1715 N  N   . TYR B 1 33  ? 35.65990  22.01621  -30.79147 1.000 40.80443  ? 126 TYR B N   1 
ATOM   1716 C  CA  . TYR B 1 33  ? 34.34954  22.27667  -30.21179 1.000 37.04032  ? 126 TYR B CA  1 
ATOM   1717 C  C   . TYR B 1 33  ? 33.64130  23.40223  -30.96166 1.000 45.93516  ? 126 TYR B C   1 
ATOM   1718 O  O   . TYR B 1 33  ? 34.23168  24.46076  -31.21631 1.000 41.82246  ? 126 TYR B O   1 
ATOM   1719 C  CB  . TYR B 1 33  ? 34.47260  22.62169  -28.72162 1.000 38.59924  ? 126 TYR B CB  1 
ATOM   1720 C  CG  . TYR B 1 33  ? 33.16615  23.03809  -28.06072 1.000 39.67397  ? 126 TYR B CG  1 
ATOM   1721 C  CD1 . TYR B 1 33  ? 32.17668  22.10346  -27.75408 1.000 41.14220  ? 126 TYR B CD1 1 
ATOM   1722 C  CD2 . TYR B 1 33  ? 32.93361  24.36615  -27.73012 1.000 43.37653  ? 126 TYR B CD2 1 
ATOM   1723 C  CE1 . TYR B 1 33  ? 30.98184  22.49427  -27.14483 1.000 44.09177  ? 126 TYR B CE1 1 
ATOM   1724 C  CE2 . TYR B 1 33  ? 31.75473  24.76391  -27.12691 1.000 41.33731  ? 126 TYR B CE2 1 
ATOM   1725 C  CZ  . TYR B 1 33  ? 30.78206  23.83189  -26.83804 1.000 43.34919  ? 126 TYR B CZ  1 
ATOM   1726 O  OH  . TYR B 1 33  ? 29.61665  24.26031  -26.23319 1.000 42.77983  ? 126 TYR B OH  1 
ATOM   1727 N  N   . SER B 1 34  ? 32.36116  23.16735  -31.29573 1.000 40.81547  ? 127 SER B N   1 
ATOM   1728 C  CA  . SER B 1 34  ? 31.51196  24.14702  -31.95001 1.000 43.14475  ? 127 SER B CA  1 
ATOM   1729 C  C   . SER B 1 34  ? 30.56775  24.75557  -30.93194 1.000 45.71182  ? 127 SER B C   1 
ATOM   1730 O  O   . SER B 1 34  ? 29.63634  24.07313  -30.48966 1.000 33.44463  ? 127 SER B O   1 
ATOM   1731 C  CB  . SER B 1 34  ? 30.71938  23.50499  -33.08142 1.000 41.04442  ? 127 SER B CB  1 
ATOM   1732 O  OG  . SER B 1 34  ? 29.60319  24.31563  -33.43089 1.000 41.76228  ? 127 SER B OG  1 
ATOM   1733 N  N   . PRO B 1 35  ? 30.76206  26.01481  -30.52539 1.000 43.71579  ? 128 PRO B N   1 
ATOM   1734 C  CA  . PRO B 1 35  ? 29.78471  26.64819  -29.62361 1.000 35.63512  ? 128 PRO B CA  1 
ATOM   1735 C  C   . PRO B 1 35  ? 28.40508  26.77684  -30.23259 1.000 39.78841  ? 128 PRO B C   1 
ATOM   1736 O  O   . PRO B 1 35  ? 27.40893  26.67906  -29.50270 1.000 44.25226  ? 128 PRO B O   1 
ATOM   1737 C  CB  . PRO B 1 35  ? 30.40000  28.03140  -29.34445 1.000 44.02683  ? 128 PRO B CB  1 
ATOM   1738 C  CG  . PRO B 1 35  ? 31.84453  27.91512  -29.71787 1.000 43.96762  ? 128 PRO B CG  1 
ATOM   1739 C  CD  . PRO B 1 35  ? 31.89112  26.90989  -30.83832 1.000 47.80074  ? 128 PRO B CD  1 
ATOM   1740 N  N   . ALA B 1 36  ? 28.31785  27.00190  -31.55007 1.000 41.82672  ? 129 ALA B N   1 
ATOM   1741 C  CA  . ALA B 1 36  ? 27.01813  27.20293  -32.17982 1.000 49.99133  ? 129 ALA B CA  1 
ATOM   1742 C  C   . ALA B 1 36  ? 26.15602  25.95737  -32.06646 1.000 43.07511  ? 129 ALA B C   1 
ATOM   1743 O  O   . ALA B 1 36  ? 24.93560  26.05079  -31.89406 1.000 46.93493  ? 129 ALA B O   1 
ATOM   1744 C  CB  . ALA B 1 36  ? 27.19825  27.60324  -33.64679 1.000 41.34003  ? 129 ALA B CB  1 
ATOM   1745 N  N   . LEU B 1 37  ? 26.76983  24.78644  -32.13206 1.000 42.46166  ? 130 LEU B N   1 
ATOM   1746 C  CA  . LEU B 1 37  ? 26.02376  23.54872  -32.00338 1.000 40.08741  ? 130 LEU B CA  1 
ATOM   1747 C  C   . LEU B 1 37  ? 26.09967  22.95361  -30.60037 1.000 48.36805  ? 130 LEU B C   1 
ATOM   1748 O  O   . LEU B 1 37  ? 25.32776  22.03717  -30.30206 1.000 49.44355  ? 130 LEU B O   1 
ATOM   1749 C  CB  . LEU B 1 37  ? 26.53163  22.53037  -33.03164 1.000 38.71203  ? 130 LEU B CB  1 
ATOM   1750 C  CG  . LEU B 1 37  ? 26.63940  22.99011  -34.49330 1.000 43.83882  ? 130 LEU B CG  1 
ATOM   1751 C  CD1 . LEU B 1 37  ? 27.67614  22.16728  -35.24851 1.000 35.32340  ? 130 LEU B CD1 1 
ATOM   1752 C  CD2 . LEU B 1 37  ? 25.30106  22.93010  -35.20498 1.000 40.14288  ? 130 LEU B CD2 1 
ATOM   1753 N  N   . ASN B 1 38  ? 26.96462  23.48719  -29.72717 1.000 41.37739  ? 131 ASN B N   1 
ATOM   1754 C  CA  . ASN B 1 38  ? 27.32321  22.86248  -28.45550 1.000 39.61522  ? 131 ASN B CA  1 
ATOM   1755 C  C   . ASN B 1 38  ? 27.67717  21.39311  -28.69485 1.000 44.75323  ? 131 ASN B C   1 
ATOM   1756 O  O   . ASN B 1 38  ? 27.07849  20.47430  -28.14171 1.000 39.92427  ? 131 ASN B O   1 
ATOM   1757 C  CB  . ASN B 1 38  ? 26.20550  23.03903  -27.42004 1.000 32.90920  ? 131 ASN B CB  1 
ATOM   1758 C  CG  . ASN B 1 38  ? 26.54350  22.40762  -26.07973 1.000 41.99692  ? 131 ASN B CG  1 
ATOM   1759 O  OD1 . ASN B 1 38  ? 27.68964  22.43517  -25.64298 1.000 41.67668  ? 131 ASN B OD1 1 
ATOM   1760 N  ND2 . ASN B 1 38  ? 25.55048  21.80265  -25.44096 1.000 34.00333  ? 131 ASN B ND2 1 
ATOM   1761 N  N   . LYS B 1 39  ? 28.63821  21.18835  -29.59975 1.000 44.06077  ? 132 LYS B N   1 
ATOM   1762 C  CA  . LYS B 1 39  ? 28.98030  19.85276  -30.08586 1.000 41.89645  ? 132 LYS B CA  1 
ATOM   1763 C  C   . LYS B 1 39  ? 30.48852  19.72680  -30.24067 1.000 44.95830  ? 132 LYS B C   1 
ATOM   1764 O  O   . LYS B 1 39  ? 31.13984  20.60107  -30.82557 1.000 47.23808  ? 132 LYS B O   1 
ATOM   1765 C  CB  . LYS B 1 39  ? 28.29753  19.55294  -31.42550 1.000 43.96408  ? 132 LYS B CB  1 
ATOM   1766 C  CG  . LYS B 1 39  ? 28.36217  18.08441  -31.87287 1.000 38.74916  ? 132 LYS B CG  1 
ATOM   1767 C  CD  . LYS B 1 39  ? 27.48269  17.87087  -33.09437 1.000 43.70166  ? 132 LYS B CD  1 
ATOM   1768 C  CE  . LYS B 1 39  ? 27.65459  16.48016  -33.70673 1.000 45.92537  ? 132 LYS B CE  1 
ATOM   1769 N  NZ  . LYS B 1 39  ? 26.44253  16.09108  -34.48911 1.000 43.33666  ? 132 LYS B NZ  1 
ATOM   1770 N  N   . LEU B 1 40  ? 31.02152  18.63539  -29.71546 1.000 38.95345  ? 133 LEU B N   1 
ATOM   1771 C  CA  . LEU B 1 40  ? 32.43664  18.30150  -29.77186 1.000 43.27887  ? 133 LEU B CA  1 
ATOM   1772 C  C   . LEU B 1 40  ? 32.69596  17.29836  -30.89158 1.000 45.52464  ? 133 LEU B C   1 
ATOM   1773 O  O   . LEU B 1 40  ? 31.99529  16.28742  -31.00614 1.000 42.49688  ? 133 LEU B O   1 
ATOM   1774 C  CB  . LEU B 1 40  ? 32.89281  17.71018  -28.43800 1.000 38.72536  ? 133 LEU B CB  1 
ATOM   1775 C  CG  . LEU B 1 40  ? 34.33661  17.22196  -28.44262 1.000 49.61928  ? 133 LEU B CG  1 
ATOM   1776 C  CD1 . LEU B 1 40  ? 35.25644  18.43467  -28.53670 1.000 52.16262  ? 133 LEU B CD1 1 
ATOM   1777 C  CD2 . LEU B 1 40  ? 34.66168  16.35675  -27.22630 1.000 40.26321  ? 133 LEU B CD2 1 
ATOM   1778 N  N   . PHE B 1 41  ? 33.70192  17.57195  -31.71023 1.000 41.67384  ? 134 PHE B N   1 
ATOM   1779 C  CA  . PHE B 1 41  ? 34.08868  16.68359  -32.79499 1.000 46.07782  ? 134 PHE B CA  1 
ATOM   1780 C  C   . PHE B 1 41  ? 35.49359  16.19358  -32.50841 1.000 41.81597  ? 134 PHE B C   1 
ATOM   1781 O  O   . PHE B 1 41  ? 36.39036  17.00665  -32.26023 1.000 48.64575  ? 134 PHE B O   1 
ATOM   1782 C  CB  . PHE B 1 41  ? 34.05940  17.40570  -34.14962 1.000 48.83211  ? 134 PHE B CB  1 
ATOM   1783 C  CG  . PHE B 1 41  ? 32.70825  17.93558  -34.54174 1.000 43.23111  ? 134 PHE B CG  1 
ATOM   1784 C  CD1 . PHE B 1 41  ? 32.23903  19.13343  -34.02266 1.000 41.22947  ? 134 PHE B CD1 1 
ATOM   1785 C  CD2 . PHE B 1 41  ? 31.93037  17.25908  -35.46839 1.000 44.36998  ? 134 PHE B CD2 1 
ATOM   1786 C  CE1 . PHE B 1 41  ? 31.00522  19.63270  -34.39431 1.000 40.15857  ? 134 PHE B CE1 1 
ATOM   1787 C  CE2 . PHE B 1 41  ? 30.69407  17.75975  -35.85418 1.000 47.47463  ? 134 PHE B CE2 1 
ATOM   1788 C  CZ  . PHE B 1 41  ? 30.22803  18.94314  -35.30870 1.000 43.48497  ? 134 PHE B CZ  1 
ATOM   1789 N  N   . CYS B 1 42  ? 35.70342  14.88270  -32.55294 1.000 44.90190  ? 135 CYS B N   1 
ATOM   1790 C  CA  . CYS B 1 42  ? 37.01427  14.39390  -32.15418 1.000 47.83492  ? 135 CYS B CA  1 
ATOM   1791 C  C   . CYS B 1 42  ? 37.34673  13.07913  -32.84369 1.000 49.23619  ? 135 CYS B C   1 
ATOM   1792 O  O   . CYS B 1 42  ? 36.46748  12.34926  -33.31253 1.000 47.38426  ? 135 CYS B O   1 
ATOM   1793 C  CB  . CYS B 1 42  ? 37.08754  14.22661  -30.63681 1.000 44.44904  ? 135 CYS B CB  1 
ATOM   1794 S  SG  . CYS B 1 42  ? 35.93865  13.01748  -29.99530 1.000 50.15237  ? 135 CYS B SG  1 
ATOM   1795 N  N   . GLN B 1 43  ? 38.64051  12.78672  -32.89951 1.000 44.71232  ? 136 GLN B N   1 
ATOM   1796 C  CA  . GLN B 1 43  ? 39.05357  11.51483  -33.45795 1.000 52.37744  ? 136 GLN B CA  1 
ATOM   1797 C  C   . GLN B 1 43  ? 38.96333  10.42751  -32.40689 1.000 46.73788  ? 136 GLN B C   1 
ATOM   1798 O  O   . GLN B 1 43  ? 38.87022  10.67901  -31.20334 1.000 45.24615  ? 136 GLN B O   1 
ATOM   1799 C  CB  . GLN B 1 43  ? 40.47027  11.57500  -34.01518 1.000 55.26837  ? 136 GLN B CB  1 
ATOM   1800 C  CG  . GLN B 1 43  ? 40.75262  12.83263  -34.78437 1.000 60.81186  ? 136 GLN B CG  1 
ATOM   1801 C  CD  . GLN B 1 43  ? 41.96199  12.71610  -35.67690 1.000 55.61133  ? 136 GLN B CD  1 
ATOM   1802 O  OE1 . GLN B 1 43  ? 43.08778  12.56451  -35.20113 1.000 62.28790  ? 136 GLN B OE1 1 
ATOM   1803 N  NE2 . GLN B 1 43  ? 41.74343  12.82074  -36.97995 1.000 64.03101  ? 136 GLN B NE2 1 
ATOM   1804 N  N   . LEU B 1 44  ? 38.97909  9.20151   -32.89095 1.000 50.74238  ? 137 LEU B N   1 
ATOM   1805 C  CA  . LEU B 1 44  ? 38.92228  8.05140   -32.01466 1.000 42.42022  ? 137 LEU B CA  1 
ATOM   1806 C  C   . LEU B 1 44  ? 40.16812  7.97921   -31.14303 1.000 41.51382  ? 137 LEU B C   1 
ATOM   1807 O  O   . LEU B 1 44  ? 41.28915  8.06887   -31.64613 1.000 54.29560  ? 137 LEU B O   1 
ATOM   1808 C  CB  . LEU B 1 44  ? 38.78641  6.80642   -32.87815 1.000 49.11941  ? 137 LEU B CB  1 
ATOM   1809 C  CG  . LEU B 1 44  ? 38.88022  5.50093   -32.12363 1.000 43.79510  ? 137 LEU B CG  1 
ATOM   1810 C  CD1 . LEU B 1 44  ? 37.48810  5.12265   -31.84029 1.000 40.51838  ? 137 LEU B CD1 1 
ATOM   1811 C  CD2 . LEU B 1 44  ? 39.55079  4.46786   -32.99464 1.000 52.41746  ? 137 LEU B CD2 1 
ATOM   1812 N  N   . ALA B 1 45  ? 39.96302  7.84894   -29.82968 1.000 42.53457  ? 138 ALA B N   1 
ATOM   1813 C  CA  . ALA B 1 45  ? 41.02363  7.63068   -28.83945 1.000 48.25392  ? 138 ALA B CA  1 
ATOM   1814 C  C   . ALA B 1 45  ? 42.02975  8.77185   -28.76391 1.000 52.66198  ? 138 ALA B C   1 
ATOM   1815 O  O   . ALA B 1 45  ? 43.14315  8.58420   -28.25755 1.000 58.01887  ? 138 ALA B O   1 
ATOM   1816 C  CB  . ALA B 1 45  ? 41.76854  6.30633   -29.09006 1.000 41.92147  ? 138 ALA B CB  1 
ATOM   1817 N  N   . LYS B 1 46  ? 41.68207  9.95536   -29.25621 1.000 52.93265  ? 139 LYS B N   1 
ATOM   1818 C  CA  . LYS B 1 46  ? 42.53902  11.12004  -29.11369 1.000 43.39495  ? 139 LYS B CA  1 
ATOM   1819 C  C   . LYS B 1 46  ? 42.07339  11.95163  -27.92658 1.000 48.44035  ? 139 LYS B C   1 
ATOM   1820 O  O   . LYS B 1 46  ? 40.89973  11.93207  -27.55508 1.000 51.01521  ? 139 LYS B O   1 
ATOM   1821 C  CB  . LYS B 1 46  ? 42.53395  11.97118  -30.38205 1.000 47.94809  ? 139 LYS B CB  1 
ATOM   1822 C  CG  . LYS B 1 46  ? 43.04496  11.25749  -31.61902 1.000 60.00331  ? 139 LYS B CG  1 
ATOM   1823 C  CD  . LYS B 1 46  ? 44.49762  10.80922  -31.50509 1.000 59.45930  ? 139 LYS B CD  1 
ATOM   1824 C  CE  . LYS B 1 46  ? 45.03468  10.40921  -32.87880 1.000 61.23432  ? 139 LYS B CE  1 
ATOM   1825 N  N   . THR B 1 47  ? 43.00528  12.69444  -27.34594 1.000 43.18322  ? 140 THR B N   1 
ATOM   1826 C  CA  . THR B 1 47  ? 42.74005  13.42768  -26.11918 1.000 47.92607  ? 140 THR B CA  1 
ATOM   1827 C  C   . THR B 1 47  ? 41.74863  14.56238  -26.36390 1.000 49.89664  ? 140 THR B C   1 
ATOM   1828 O  O   . THR B 1 47  ? 41.87149  15.30445  -27.34201 1.000 52.05010  ? 140 THR B O   1 
ATOM   1829 C  CB  . THR B 1 47  ? 44.06085  13.96919  -25.56627 1.000 58.19752  ? 140 THR B CB  1 
ATOM   1830 O  OG1 . THR B 1 47  ? 45.00496  12.88965  -25.43593 1.000 55.15342  ? 140 THR B OG1 1 
ATOM   1831 C  CG2 . THR B 1 47  ? 43.86176  14.63265  -24.22931 1.000 47.50017  ? 140 THR B CG2 1 
ATOM   1832 N  N   . CYS B 1 48  ? 40.75567  14.68628  -25.48253 1.000 51.03565  ? 141 CYS B N   1 
ATOM   1833 C  CA  . CYS B 1 48  ? 39.76038  15.76157  -25.53377 1.000 45.28591  ? 141 CYS B CA  1 
ATOM   1834 C  C   . CYS B 1 48  ? 39.79368  16.52600  -24.22653 1.000 46.33477  ? 141 CYS B C   1 
ATOM   1835 O  O   . CYS B 1 48  ? 39.21598  16.06477  -23.22814 1.000 41.61574  ? 141 CYS B O   1 
ATOM   1836 C  CB  . CYS B 1 48  ? 38.35419  15.22298  -25.77356 1.000 47.91187  ? 141 CYS B CB  1 
ATOM   1837 S  SG  . CYS B 1 48  ? 38.13125  14.28875  -27.27966 1.000 47.61268  ? 141 CYS B SG  1 
ATOM   1838 N  N   . PRO B 1 49  ? 40.43046  17.69570  -24.18007 1.000 39.28042  ? 142 PRO B N   1 
ATOM   1839 C  CA  . PRO B 1 49  ? 40.51436  18.44112  -22.92198 1.000 37.83372  ? 142 PRO B CA  1 
ATOM   1840 C  C   . PRO B 1 49  ? 39.24630  19.24445  -22.67641 1.000 38.84557  ? 142 PRO B C   1 
ATOM   1841 O  O   . PRO B 1 49  ? 38.80122  19.99526  -23.54145 1.000 49.55960  ? 142 PRO B O   1 
ATOM   1842 C  CB  . PRO B 1 49  ? 41.73066  19.35411  -23.13423 1.000 48.43966  ? 142 PRO B CB  1 
ATOM   1843 C  CG  . PRO B 1 49  ? 41.82176  19.52253  -24.60855 1.000 39.37796  ? 142 PRO B CG  1 
ATOM   1844 C  CD  . PRO B 1 49  ? 41.29307  18.26698  -25.23035 1.000 45.83843  ? 142 PRO B CD  1 
ATOM   1845 N  N   . VAL B 1 50  ? 38.67357  19.08610  -21.48617 1.000 33.58035  ? 143 VAL B N   1 
ATOM   1846 C  CA  . VAL B 1 50  ? 37.46723  19.79665  -21.07710 1.000 42.87875  ? 143 VAL B CA  1 
ATOM   1847 C  C   . VAL B 1 50  ? 37.79971  20.60419  -19.83917 1.000 42.56913  ? 143 VAL B C   1 
ATOM   1848 O  O   . VAL B 1 50  ? 38.36584  20.06871  -18.88410 1.000 45.17118  ? 143 VAL B O   1 
ATOM   1849 C  CB  . VAL B 1 50  ? 36.29871  18.84605  -20.77378 1.000 38.01639  ? 143 VAL B CB  1 
ATOM   1850 C  CG1 . VAL B 1 50  ? 35.07098  19.64329  -20.33651 1.000 36.57307  ? 143 VAL B CG1 1 
ATOM   1851 C  CG2 . VAL B 1 50  ? 35.98818  17.96392  -21.97155 1.000 42.19783  ? 143 VAL B CG2 1 
ATOM   1852 N  N   A GLN B 1 51  ? 37.45854  21.88961  -19.85982 0.500 40.61417  ? 144 GLN B N   1 
ATOM   1853 N  N   B GLN B 1 51  ? 37.44290  21.88281  -19.85090 0.500 40.61015  ? 144 GLN B N   1 
ATOM   1854 C  CA  A GLN B 1 51  ? 37.70639  22.77750  -18.73168 0.500 43.13332  ? 144 GLN B CA  1 
ATOM   1855 C  CA  B GLN B 1 51  ? 37.71684  22.76678  -18.72812 0.500 43.13215  ? 144 GLN B CA  1 
ATOM   1856 C  C   A GLN B 1 51  ? 36.50399  22.76221  -17.79702 0.500 42.53181  ? 144 GLN B C   1 
ATOM   1857 C  C   B GLN B 1 51  ? 36.51191  22.79891  -17.79546 0.500 42.54258  ? 144 GLN B C   1 
ATOM   1858 O  O   A GLN B 1 51  ? 35.35890  22.85111  -18.25023 0.500 43.66498  ? 144 GLN B O   1 
ATOM   1859 O  O   B GLN B 1 51  ? 35.37228  22.94235  -18.24871 0.500 43.68645  ? 144 GLN B O   1 
ATOM   1860 C  CB  A GLN B 1 51  ? 37.97297  24.20660  -19.21428 0.500 43.21489  ? 144 GLN B CB  1 
ATOM   1861 C  CB  B GLN B 1 51  ? 38.05125  24.17469  -19.22922 0.500 43.21308  ? 144 GLN B CB  1 
ATOM   1862 C  CG  A GLN B 1 51  ? 39.40253  24.49554  -19.63384 0.500 42.99990  ? 144 GLN B CG  1 
ATOM   1863 C  CG  B GLN B 1 51  ? 38.80987  24.19697  -20.55473 0.500 39.97232  ? 144 GLN B CG  1 
ATOM   1864 C  CD  A GLN B 1 51  ? 39.66104  25.98490  -19.79244 0.500 50.23244  ? 144 GLN B CD  1 
ATOM   1865 C  CD  B GLN B 1 51  ? 40.25270  23.75958  -20.40512 0.500 46.42610  ? 144 GLN B CD  1 
ATOM   1866 O  OE1 A GLN B 1 51  ? 38.72295  26.78478  -19.83819 0.500 44.39427  ? 144 GLN B OE1 1 
ATOM   1867 O  OE1 B GLN B 1 51  ? 40.86391  23.96650  -19.35490 0.500 49.85664  ? 144 GLN B OE1 1 
ATOM   1868 N  NE2 A GLN B 1 51  ? 40.93361  26.36603  -19.87287 0.500 51.17432  ? 144 GLN B NE2 1 
ATOM   1869 N  NE2 B GLN B 1 51  ? 40.81043  23.15521  -21.45766 0.500 39.75579  ? 144 GLN B NE2 1 
ATOM   1870 N  N   . LEU B 1 52  ? 36.76465  22.65375  -16.49713 1.000 42.27064  ? 145 LEU B N   1 
ATOM   1871 C  CA  . LEU B 1 52  ? 35.72331  22.71969  -15.47823 1.000 36.28844  ? 145 LEU B CA  1 
ATOM   1872 C  C   . LEU B 1 52  ? 35.82865  24.04632  -14.74107 1.000 43.28535  ? 145 LEU B C   1 
ATOM   1873 O  O   . LEU B 1 52  ? 36.92658  24.47103  -14.36857 1.000 47.43314  ? 145 LEU B O   1 
ATOM   1874 C  CB  . LEU B 1 52  ? 35.82692  21.56776  -14.48405 1.000 46.09792  ? 145 LEU B CB  1 
ATOM   1875 C  CG  . LEU B 1 52  ? 36.04338  20.15831  -15.03921 1.000 52.55034  ? 145 LEU B CG  1 
ATOM   1876 C  CD1 . LEU B 1 52  ? 35.78231  19.14999  -13.94894 1.000 49.09176  ? 145 LEU B CD1 1 
ATOM   1877 C  CD2 . LEU B 1 52  ? 35.14652  19.88159  -16.22096 1.000 48.28186  ? 145 LEU B CD2 1 
ATOM   1878 N  N   . TRP B 1 53  ? 34.69630  24.70346  -14.53470 1.000 41.63338  ? 146 TRP B N   1 
ATOM   1879 C  CA  . TRP B 1 53  ? 34.69598  25.97586  -13.83505 1.000 43.79830  ? 146 TRP B CA  1 
ATOM   1880 C  C   . TRP B 1 53  ? 33.72952  25.91556  -12.66729 1.000 41.52827  ? 146 TRP B C   1 
ATOM   1881 O  O   . TRP B 1 53  ? 32.61332  25.39928  -12.79801 1.000 44.66970  ? 146 TRP B O   1 
ATOM   1882 C  CB  . TRP B 1 53  ? 34.31916  27.12488  -14.76988 0.400 27.14520  ? 146 TRP B CB  1 
ATOM   1883 N  N   . VAL B 1 54  ? 34.17082  26.44938  -11.52897 1.000 38.26609  ? 147 VAL B N   1 
ATOM   1884 C  CA  . VAL B 1 54  ? 33.32564  26.67294  -10.36473 1.000 40.39935  ? 147 VAL B CA  1 
ATOM   1885 C  C   . VAL B 1 54  ? 33.56548  28.08788  -9.84926  1.000 43.17693  ? 147 VAL B C   1 
ATOM   1886 O  O   . VAL B 1 54  ? 34.68005  28.61744  -9.91463  1.000 43.49774  ? 147 VAL B O   1 
ATOM   1887 C  CB  . VAL B 1 54  ? 33.60099  25.64732  -9.24232  1.000 41.22367  ? 147 VAL B CB  1 
ATOM   1888 C  CG1 . VAL B 1 54  ? 33.08513  24.25298  -9.62977  1.000 43.00706  ? 147 VAL B CG1 1 
ATOM   1889 C  CG2 . VAL B 1 54  ? 35.08903  25.60674  -8.90660  1.000 34.12995  ? 147 VAL B CG2 1 
ATOM   1890 N  N   . ASP B 1 55  ? 32.50547  28.69757  -9.32289  1.000 43.94349  ? 148 ASP B N   1 
ATOM   1891 C  CA  . ASP B 1 55  ? 32.62103  29.99836  -8.66624  1.000 50.08750  ? 148 ASP B CA  1 
ATOM   1892 C  C   . ASP B 1 55  ? 33.23124  29.89130  -7.27338  1.000 53.90519  ? 148 ASP B C   1 
ATOM   1893 O  O   . ASP B 1 55  ? 33.99001  30.77141  -6.85139  1.000 51.90928  ? 148 ASP B O   1 
ATOM   1894 C  CB  . ASP B 1 55  ? 31.24964  30.65081  -8.57650  1.000 42.93300  ? 148 ASP B CB  1 
ATOM   1895 C  CG  . ASP B 1 55  ? 30.74303  31.09441  -9.92103  1.000 53.97859  ? 148 ASP B CG  1 
ATOM   1896 O  OD1 . ASP B 1 55  ? 31.58096  31.48109  -10.76871 1.000 58.66575  ? 148 ASP B OD1 1 
ATOM   1897 O  OD2 . ASP B 1 55  ? 29.51201  31.06212  -10.12854 1.000 56.77728  ? 148 ASP B OD2 1 
ATOM   1898 N  N   . SER B 1 56  ? 32.89183  28.84151  -6.53735  1.000 54.80268  ? 149 SER B N   1 
ATOM   1899 C  CA  . SER B 1 56  ? 33.40598  28.62713  -5.19432  1.000 57.38988  ? 149 SER B CA  1 
ATOM   1900 C  C   . SER B 1 56  ? 33.88114  27.18827  -5.09129  1.000 52.93924  ? 149 SER B C   1 
ATOM   1901 O  O   . SER B 1 56  ? 33.43452  26.32204  -5.84258  1.000 47.46280  ? 149 SER B O   1 
ATOM   1902 C  CB  . SER B 1 56  ? 32.35163  28.92786  -4.11044  1.000 54.27331  ? 149 SER B CB  1 
ATOM   1903 O  OG  . SER B 1 56  ? 31.03012  28.67304  -4.56063  1.000 59.05964  ? 149 SER B OG  1 
ATOM   1904 N  N   . THR B 1 57  ? 34.80773  26.95060  -4.18130  1.000 49.98691  ? 150 THR B N   1 
ATOM   1905 C  CA  . THR B 1 57  ? 35.43772  25.64679  -4.10196  1.000 52.06793  ? 150 THR B CA  1 
ATOM   1906 C  C   . THR B 1 57  ? 34.45568  24.62895  -3.53347  1.000 51.06131  ? 150 THR B C   1 
ATOM   1907 O  O   . THR B 1 57  ? 33.76999  24.92320  -2.54698  1.000 44.77457  ? 150 THR B O   1 
ATOM   1908 C  CB  . THR B 1 57  ? 36.69274  25.72462  -3.24817  1.000 58.50013  ? 150 THR B CB  1 
ATOM   1909 O  OG1 . THR B 1 57  ? 37.59977  26.65526  -3.85016  1.000 60.51227  ? 150 THR B OG1 1 
ATOM   1910 C  CG2 . THR B 1 57  ? 37.36400  24.36499  -3.15547  1.000 47.32605  ? 150 THR B CG2 1 
ATOM   1911 N  N   . PRO B 1 58  ? 34.31621  23.45793  -4.15195  1.000 47.98809  ? 151 PRO B N   1 
ATOM   1912 C  CA  . PRO B 1 58  ? 33.44327  22.42532  -3.60416  1.000 44.08797  ? 151 PRO B CA  1 
ATOM   1913 C  C   . PRO B 1 58  ? 34.16704  21.63851  -2.52610  1.000 40.80252  ? 151 PRO B C   1 
ATOM   1914 O  O   . PRO B 1 58  ? 35.40488  21.64942  -2.47970  1.000 40.21863  ? 151 PRO B O   1 
ATOM   1915 C  CB  . PRO B 1 58  ? 33.12997  21.56094  -4.83092  1.000 45.42297  ? 151 PRO B CB  1 
ATOM   1916 C  CG  . PRO B 1 58  ? 34.36075  21.66901  -5.65939  1.000 49.31428  ? 151 PRO B CG  1 
ATOM   1917 C  CD  . PRO B 1 58  ? 34.85378  23.08030  -5.47085  1.000 44.57692  ? 151 PRO B CD  1 
ATOM   1918 N  N   . PRO B 1 59  ? 33.44121  20.96061  -1.63573  1.000 40.69633  ? 152 PRO B N   1 
ATOM   1919 C  CA  . PRO B 1 59  ? 34.07665  20.33091  -0.47199  1.000 41.66749  ? 152 PRO B CA  1 
ATOM   1920 C  C   . PRO B 1 59  ? 35.00906  19.20530  -0.87729  1.000 39.29511  ? 152 PRO B C   1 
ATOM   1921 O  O   . PRO B 1 59  ? 34.85650  18.61499  -1.95578  1.000 43.22689  ? 152 PRO B O   1 
ATOM   1922 C  CB  . PRO B 1 59  ? 32.88183  19.79593  0.33193   1.000 47.65881  ? 152 PRO B CB  1 
ATOM   1923 C  CG  . PRO B 1 59  ? 31.73481  20.65961  -0.07721  1.000 40.15033  ? 152 PRO B CG  1 
ATOM   1924 C  CD  . PRO B 1 59  ? 31.97244  20.90177  -1.53944  1.000 46.85116  ? 152 PRO B CD  1 
ATOM   1925 N  N   . PRO B 1 60  ? 35.99104  18.88340  -0.03593  1.000 47.40964  ? 153 PRO B N   1 
ATOM   1926 C  CA  . PRO B 1 60  ? 36.83274  17.71242  -0.30323  1.000 42.30043  ? 153 PRO B CA  1 
ATOM   1927 C  C   . PRO B 1 60  ? 35.97574  16.45913  -0.45572  1.000 40.73693  ? 153 PRO B C   1 
ATOM   1928 O  O   . PRO B 1 60  ? 34.95111  16.29576  0.20991   1.000 36.38750  ? 153 PRO B O   1 
ATOM   1929 C  CB  . PRO B 1 60  ? 37.72972  17.63499  0.93700   1.000 43.44351  ? 153 PRO B CB  1 
ATOM   1930 C  CG  . PRO B 1 60  ? 37.71548  19.00854  1.51306   1.000 39.96326  ? 153 PRO B CG  1 
ATOM   1931 C  CD  . PRO B 1 60  ? 36.34587  19.54430  1.23555   1.000 47.52380  ? 153 PRO B CD  1 
ATOM   1932 N  N   . GLY B 1 61  ? 36.36772  15.60908  -1.39372  1.000 35.61565  ? 154 GLY B N   1 
ATOM   1933 C  CA  . GLY B 1 61  ? 35.59945  14.43253  -1.75064  1.000 38.20648  ? 154 GLY B CA  1 
ATOM   1934 C  C   . GLY B 1 61  ? 34.57349  14.63379  -2.84698  1.000 39.39859  ? 154 GLY B C   1 
ATOM   1935 O  O   . GLY B 1 61  ? 33.92167  13.66622  -3.23855  1.000 38.28697  ? 154 GLY B O   1 
ATOM   1936 N  N   . THR B 1 62  ? 34.38825  15.85736  -3.33122  1.000 37.02771  ? 155 THR B N   1 
ATOM   1937 C  CA  . THR B 1 62  ? 33.52523  16.10318  -4.47835  1.000 34.56426  ? 155 THR B CA  1 
ATOM   1938 C  C   . THR B 1 62  ? 34.10751  15.38772  -5.69008  1.000 32.67295  ? 155 THR B C   1 
ATOM   1939 O  O   . THR B 1 62  ? 35.32938  15.31762  -5.84206  1.000 37.62953  ? 155 THR B O   1 
ATOM   1940 C  CB  . THR B 1 62  ? 33.44020  17.62403  -4.72730  1.000 43.21510  ? 155 THR B CB  1 
ATOM   1941 O  OG1 . THR B 1 62  ? 32.88464  18.26998  -3.57256  1.000 38.36433  ? 155 THR B OG1 1 
ATOM   1942 C  CG2 . THR B 1 62  ? 32.58221  17.96524  -5.94818  1.000 35.01550  ? 155 THR B CG2 1 
ATOM   1943 N  N   . ARG B 1 63  ? 33.24299  14.84091  -6.55330  1.000 30.72966  ? 156 ARG B N   1 
ATOM   1944 C  CA  . ARG B 1 63  ? 33.70602  14.08016  -7.71398  1.000 36.72313  ? 156 ARG B CA  1 
ATOM   1945 C  C   . ARG B 1 63  ? 33.06353  14.58176  -9.00467  1.000 33.97017  ? 156 ARG B C   1 
ATOM   1946 O  O   . ARG B 1 63  ? 32.05722  15.29564  -8.98664  1.000 35.20637  ? 156 ARG B O   1 
ATOM   1947 C  CB  . ARG B 1 63  ? 33.41775  12.58001  -7.53288  1.000 37.96516  ? 156 ARG B CB  1 
ATOM   1948 C  CG  . ARG B 1 63  ? 34.17549  11.95746  -6.35535  1.000 34.49509  ? 156 ARG B CG  1 
ATOM   1949 C  CD  . ARG B 1 63  ? 34.41577  10.48485  -6.58602  1.000 40.82229  ? 156 ARG B CD  1 
ATOM   1950 N  NE  . ARG B 1 63  ? 33.17392  9.72439   -6.53354  1.000 39.72010  ? 156 ARG B NE  1 
ATOM   1951 C  CZ  . ARG B 1 63  ? 33.09295  8.42654   -6.78592  1.000 45.30281  ? 156 ARG B CZ  1 
ATOM   1952 N  NH1 . ARG B 1 63  ? 34.15486  7.73296   -7.14873  1.000 41.30273  ? 156 ARG B NH1 1 
ATOM   1953 N  NH2 . ARG B 1 63  ? 31.92195  7.80794   -6.65476  1.000 40.04888  ? 156 ARG B NH2 1 
ATOM   1954 N  N   . VAL B 1 64  ? 33.66177  14.19795  -10.13716 1.000 35.98095  ? 157 VAL B N   1 
ATOM   1955 C  CA  . VAL B 1 64  ? 33.17892  14.56666  -11.47226 1.000 35.43867  ? 157 VAL B CA  1 
ATOM   1956 C  C   . VAL B 1 64  ? 32.96094  13.30434  -12.30108 1.000 36.67288  ? 157 VAL B C   1 
ATOM   1957 O  O   . VAL B 1 64  ? 33.91687  12.55613  -12.56563 1.000 35.71501  ? 157 VAL B O   1 
ATOM   1958 C  CB  . VAL B 1 64  ? 34.16452  15.48420  -12.20252 1.000 35.86927  ? 157 VAL B CB  1 
ATOM   1959 C  CG1 . VAL B 1 64  ? 33.54411  15.96874  -13.48638 1.000 34.85964  ? 157 VAL B CG1 1 
ATOM   1960 C  CG2 . VAL B 1 64  ? 34.59000  16.61697  -11.30242 1.000 36.27331  ? 157 VAL B CG2 1 
ATOM   1961 N  N   . ARG B 1 65  ? 31.72980  13.10643  -12.77251 1.000 38.49356  ? 158 ARG B N   1 
ATOM   1962 C  CA  . ARG B 1 65  ? 31.34515  11.90754  -13.51251 1.000 32.67352  ? 158 ARG B CA  1 
ATOM   1963 C  C   . ARG B 1 65  ? 30.88439  12.27466  -14.91706 1.000 36.13940  ? 158 ARG B C   1 
ATOM   1964 O  O   . ARG B 1 65  ? 30.19745  13.28450  -15.10805 1.000 38.43475  ? 158 ARG B O   1 
ATOM   1965 C  CB  . ARG B 1 65  ? 30.21802  11.16073  -12.79089 1.000 34.87274  ? 158 ARG B CB  1 
ATOM   1966 C  CG  . ARG B 1 65  ? 29.67331  9.90615   -13.53000 1.000 35.25541  ? 158 ARG B CG  1 
ATOM   1967 C  CD  . ARG B 1 65  ? 28.49675  9.32757   -12.77719 1.000 30.54561  ? 158 ARG B CD  1 
ATOM   1968 N  NE  . ARG B 1 65  ? 28.83926  9.16183   -11.36781 1.000 31.93275  ? 158 ARG B NE  1 
ATOM   1969 C  CZ  . ARG B 1 65  ? 29.52581  8.12749   -10.89779 1.000 40.58346  ? 158 ARG B CZ  1 
ATOM   1970 N  NH1 . ARG B 1 65  ? 29.94797  7.15457   -11.69344 1.000 36.33591  ? 158 ARG B NH1 1 
ATOM   1971 N  NH2 . ARG B 1 65  ? 29.79544  8.06145   -9.59942  1.000 42.35937  ? 158 ARG B NH2 1 
ATOM   1972 N  N   . ALA B 1 66  ? 31.25808  11.44042  -15.88780 1.000 32.15873  ? 159 ALA B N   1 
ATOM   1973 C  CA  . ALA B 1 66  ? 30.92426  11.59951  -17.29944 1.000 33.43484  ? 159 ALA B CA  1 
ATOM   1974 C  C   . ALA B 1 66  ? 30.14098  10.38545  -17.78895 1.000 37.36159  ? 159 ALA B C   1 
ATOM   1975 O  O   . ALA B 1 66  ? 30.53870  9.24864   -17.53758 1.000 36.02826  ? 159 ALA B O   1 
ATOM   1976 C  CB  . ALA B 1 66  ? 32.19303  11.75920  -18.13138 1.000 33.80024  ? 159 ALA B CB  1 
ATOM   1977 N  N   . MET B 1 67  ? 29.04890  10.62183  -18.51336 1.000 37.24280  ? 160 MET B N   1 
ATOM   1978 C  CA  . MET B 1 67  ? 28.18306  9.55122   -18.98774 1.000 36.29338  ? 160 MET B CA  1 
ATOM   1979 C  C   . MET B 1 67  ? 27.63255  9.91859   -20.35502 1.000 31.84079  ? 160 MET B C   1 
ATOM   1980 O  O   . MET B 1 67  ? 27.24245  11.06422  -20.57502 1.000 42.21697  ? 160 MET B O   1 
ATOM   1981 C  CB  . MET B 1 67  ? 27.03757  9.31440   -17.99286 1.000 37.19022  ? 160 MET B CB  1 
ATOM   1982 C  CG  . MET B 1 67  ? 26.21980  8.09196   -18.26723 1.000 41.83826  ? 160 MET B CG  1 
ATOM   1983 S  SD  . MET B 1 67  ? 24.70455  8.03800   -17.29010 1.000 49.24796  ? 160 MET B SD  1 
ATOM   1984 C  CE  . MET B 1 67  ? 25.31182  7.31943   -15.76280 1.000 36.16622  ? 160 MET B CE  1 
ATOM   1985 N  N   . ALA B 1 68  ? 27.60373  8.96659   -21.27728 1.000 30.90740  ? 161 ALA B N   1 
ATOM   1986 C  CA  . ALA B 1 68  ? 27.02302  9.20764   -22.59439 1.000 33.78016  ? 161 ALA B CA  1 
ATOM   1987 C  C   . ALA B 1 68  ? 25.61346  8.64436   -22.66933 1.000 36.19085  ? 161 ALA B C   1 
ATOM   1988 O  O   . ALA B 1 68  ? 25.33922  7.56351   -22.14645 1.000 41.05398  ? 161 ALA B O   1 
ATOM   1989 C  CB  . ALA B 1 68  ? 27.87218  8.59761   -23.71388 1.000 30.62680  ? 161 ALA B CB  1 
ATOM   1990 N  N   . ILE B 1 69  ? 24.71494  9.39018   -23.31215 1.000 35.81798  ? 162 ILE B N   1 
ATOM   1991 C  CA  . ILE B 1 69  ? 23.37886  8.90838   -23.65122 1.000 41.19614  ? 162 ILE B CA  1 
ATOM   1992 C  C   . ILE B 1 69  ? 23.08251  9.30309   -25.09342 1.000 39.85198  ? 162 ILE B C   1 
ATOM   1993 O  O   . ILE B 1 69  ? 23.68076  10.23310  -25.63276 1.000 39.10108  ? 162 ILE B O   1 
ATOM   1994 C  CB  . ILE B 1 69  ? 22.29138  9.46630   -22.70713 1.000 41.05996  ? 162 ILE B CB  1 
ATOM   1995 C  CG1 . ILE B 1 69  ? 22.24377  10.99731  -22.80973 1.000 42.87737  ? 162 ILE B CG1 1 
ATOM   1996 C  CG2 . ILE B 1 69  ? 22.52888  9.00458   -21.26331 1.000 43.18975  ? 162 ILE B CG2 1 
ATOM   1997 C  CD1 . ILE B 1 69  ? 20.83314  11.59728  -22.78671 1.000 45.63098  ? 162 ILE B CD1 1 
ATOM   1998 N  N   . TYR B 1 70  ? 22.15575  8.57887   -25.72409 1.000 36.26741  ? 163 TYR B N   1 
ATOM   1999 C  CA  . TYR B 1 70  ? 21.72315  8.94661   -27.06966 1.000 38.71154  ? 163 TYR B CA  1 
ATOM   2000 C  C   . TYR B 1 70  ? 20.84569  10.19552  -27.01762 1.000 45.46463  ? 163 TYR B C   1 
ATOM   2001 O  O   . TYR B 1 70  ? 20.05897  10.38607  -26.08806 1.000 46.21407  ? 163 TYR B O   1 
ATOM   2002 C  CB  . TYR B 1 70  ? 20.98497  7.78559   -27.74382 1.000 41.51245  ? 163 TYR B CB  1 
ATOM   2003 C  CG  . TYR B 1 70  ? 21.92212  6.64558   -28.11329 1.000 41.33591  ? 163 TYR B CG  1 
ATOM   2004 C  CD1 . TYR B 1 70  ? 22.83683  6.78852   -29.14981 1.000 39.70121  ? 163 TYR B CD1 1 
ATOM   2005 C  CD2 . TYR B 1 70  ? 21.92734  5.44539   -27.39623 1.000 41.30469  ? 163 TYR B CD2 1 
ATOM   2006 C  CE1 . TYR B 1 70  ? 23.72770  5.76505   -29.47809 1.000 40.08544  ? 163 TYR B CE1 1 
ATOM   2007 C  CE2 . TYR B 1 70  ? 22.81069  4.40233   -27.72689 1.000 33.02061  ? 163 TYR B CE2 1 
ATOM   2008 C  CZ  . TYR B 1 70  ? 23.70634  4.57832   -28.76828 1.000 37.41039  ? 163 TYR B CZ  1 
ATOM   2009 O  OH  . TYR B 1 70  ? 24.60228  3.58622   -29.10905 1.000 41.84624  ? 163 TYR B OH  1 
ATOM   2010 N  N   . LYS B 1 71  ? 21.01132  11.07030  -28.01137 1.000 46.08642  ? 164 LYS B N   1 
ATOM   2011 C  CA  . LYS B 1 71  ? 20.27807  12.33248  -28.03337 1.000 41.40115  ? 164 LYS B CA  1 
ATOM   2012 C  C   . LYS B 1 71  ? 18.81893  12.15261  -28.42999 1.000 48.26398  ? 164 LYS B C   1 
ATOM   2013 O  O   . LYS B 1 71  ? 17.93125  12.75007  -27.81222 1.000 42.61803  ? 164 LYS B O   1 
ATOM   2014 C  CB  . LYS B 1 71  ? 20.95671  13.30435  -28.99387 1.000 40.54855  ? 164 LYS B CB  1 
ATOM   2015 C  CG  . LYS B 1 71  ? 20.60076  14.74017  -28.76151 1.000 45.96865  ? 164 LYS B CG  1 
ATOM   2016 C  CD  . LYS B 1 71  ? 21.32497  15.62169  -29.74847 1.000 46.96759  ? 164 LYS B CD  1 
ATOM   2017 C  CE  . LYS B 1 71  ? 20.73939  17.04024  -29.74408 1.000 59.18713  ? 164 LYS B CE  1 
ATOM   2018 N  NZ  . LYS B 1 71  ? 21.11090  17.80296  -30.97493 1.000 63.99016  ? 164 LYS B NZ  1 
ATOM   2019 N  N   . GLN B 1 72  ? 18.55361  11.34596  -29.45567 1.000 43.98144  ? 165 GLN B N   1 
ATOM   2020 C  CA  . GLN B 1 72  ? 17.20181  11.21999  -29.99390 1.000 49.09305  ? 165 GLN B CA  1 
ATOM   2021 C  C   . GLN B 1 72  ? 16.28751  10.43464  -29.05778 1.000 52.83607  ? 165 GLN B C   1 
ATOM   2022 O  O   . GLN B 1 72  ? 16.67171  9.39643   -28.51154 1.000 42.69565  ? 165 GLN B O   1 
ATOM   2023 C  CB  . GLN B 1 72  ? 17.25366  10.54203  -31.35828 1.000 50.43252  ? 165 GLN B CB  1 
ATOM   2024 C  CG  . GLN B 1 72  ? 18.38282  11.06194  -32.21185 1.000 47.03787  ? 165 GLN B CG  1 
ATOM   2025 C  CD  . GLN B 1 72  ? 18.46754  10.38244  -33.55028 1.000 57.73317  ? 165 GLN B CD  1 
ATOM   2026 O  OE1 . GLN B 1 72  ? 19.06275  9.30972   -33.68782 1.000 48.69483  ? 165 GLN B OE1 1 
ATOM   2027 N  NE2 . GLN B 1 72  ? 17.88396  11.01320  -34.55918 1.000 63.02178  ? 165 GLN B NE2 1 
ATOM   2028 N  N   . SER B 1 73  ? 15.04935  10.91834  -28.91474 1.000 53.60627  ? 166 SER B N   1 
ATOM   2029 C  CA  . SER B 1 73  ? 14.14624  10.37951  -27.90220 1.000 52.31263  ? 166 SER B CA  1 
ATOM   2030 C  C   . SER B 1 73  ? 13.82545  8.90921   -28.14247 1.000 46.13011  ? 166 SER B C   1 
ATOM   2031 O  O   . SER B 1 73  ? 13.65959  8.15025   -27.18262 1.000 51.23497  ? 166 SER B O   1 
ATOM   2032 C  CB  . SER B 1 73  ? 12.86070  11.21141  -27.84364 1.000 56.80810  ? 166 SER B CB  1 
ATOM   2033 O  OG  . SER B 1 73  ? 11.96172  10.88664  -28.88971 1.000 51.76715  ? 166 SER B OG  1 
ATOM   2034 N  N   . GLN B 1 74  ? 13.75838  8.47649   -29.40444 1.000 44.79115  ? 167 GLN B N   1 
ATOM   2035 C  CA  . GLN B 1 74  ? 13.47545  7.07306   -29.67759 1.000 53.01071  ? 167 GLN B CA  1 
ATOM   2036 C  C   . GLN B 1 74  ? 14.59815  6.14575   -29.20882 1.000 48.14583  ? 167 GLN B C   1 
ATOM   2037 O  O   . GLN B 1 74  ? 14.36821  4.93990   -29.07169 1.000 54.00819  ? 167 GLN B O   1 
ATOM   2038 C  CB  . GLN B 1 74  ? 13.19239  6.87829   -31.17381 1.000 52.13071  ? 167 GLN B CB  1 
ATOM   2039 C  CG  . GLN B 1 74  ? 14.35870  7.21056   -32.09489 1.000 60.86867  ? 167 GLN B CG  1 
ATOM   2040 C  CD  . GLN B 1 74  ? 14.36680  8.67264   -32.56214 1.000 70.33866  ? 167 GLN B CD  1 
ATOM   2041 O  OE1 . GLN B 1 74  ? 13.89440  9.56980   -31.85724 1.000 66.34233  ? 167 GLN B OE1 1 
ATOM   2042 N  NE2 . GLN B 1 74  ? 14.92472  8.91318   -33.75336 1.000 63.85943  ? 167 GLN B NE2 1 
ATOM   2043 N  N   . HIS B 1 75  ? 15.79057  6.67465   -28.91758 1.000 44.02780  ? 168 HIS B N   1 
ATOM   2044 C  CA  . HIS B 1 75  ? 16.91430  5.84543   -28.48800 1.000 50.21229  ? 168 HIS B CA  1 
ATOM   2045 C  C   . HIS B 1 75  ? 17.44596  6.14927   -27.09585 1.000 47.30594  ? 168 HIS B C   1 
ATOM   2046 O  O   . HIS B 1 75  ? 18.42481  5.51907   -26.68921 1.000 44.71813  ? 168 HIS B O   1 
ATOM   2047 C  CB  . HIS B 1 75  ? 18.06623  5.97854   -29.48639 1.000 46.85392  ? 168 HIS B CB  1 
ATOM   2048 C  CG  . HIS B 1 75  ? 17.70014  5.53107   -30.85786 1.000 50.98356  ? 168 HIS B CG  1 
ATOM   2049 N  ND1 . HIS B 1 75  ? 17.70598  6.37843   -31.94590 1.000 54.61238  ? 168 HIS B ND1 1 
ATOM   2050 C  CD2 . HIS B 1 75  ? 17.26853  4.33206   -31.31146 1.000 36.86997  ? 168 HIS B CD2 1 
ATOM   2051 C  CE1 . HIS B 1 75  ? 17.32424  5.71100   -33.01975 1.000 49.89901  ? 168 HIS B CE1 1 
ATOM   2052 N  NE2 . HIS B 1 75  ? 17.05212  4.46824   -32.66096 1.000 50.75706  ? 168 HIS B NE2 1 
ATOM   2053 N  N   . MET B 1 76  ? 16.83468  7.07798   -26.35306 1.000 43.95961  ? 169 MET B N   1 
ATOM   2054 C  CA  . MET B 1 76  ? 17.40636  7.52889   -25.08602 1.000 41.49688  ? 169 MET B CA  1 
ATOM   2055 C  C   . MET B 1 76  ? 17.49286  6.42766   -24.04287 1.000 39.52326  ? 169 MET B C   1 
ATOM   2056 O  O   . MET B 1 76  ? 18.31291  6.53173   -23.12635 1.000 47.03042  ? 169 MET B O   1 
ATOM   2057 C  CB  . MET B 1 76  ? 16.58879  8.68257   -24.50645 1.000 42.41453  ? 169 MET B CB  1 
ATOM   2058 C  CG  . MET B 1 76  ? 16.65620  9.97227   -25.28173 1.000 54.81811  ? 169 MET B CG  1 
ATOM   2059 S  SD  . MET B 1 76  ? 15.94839  11.34119  -24.33318 1.000 64.41595  ? 169 MET B SD  1 
ATOM   2060 C  CE  . MET B 1 76  ? 14.41959  10.56269  -23.78778 1.000 60.58867  ? 169 MET B CE  1 
ATOM   2061 N  N   . THR B 1 77  ? 16.66149  5.38872   -24.14560 1.000 46.17828  ? 170 THR B N   1 
ATOM   2062 C  CA  . THR B 1 77  ? 16.68526  4.29085   -23.18602 1.000 42.59263  ? 170 THR B CA  1 
ATOM   2063 C  C   . THR B 1 77  ? 17.76045  3.24860   -23.48493 1.000 42.44529  ? 170 THR B C   1 
ATOM   2064 O  O   . THR B 1 77  ? 17.95829  2.34215   -22.66845 1.000 40.85227  ? 170 THR B O   1 
ATOM   2065 C  CB  . THR B 1 77  ? 15.31712  3.58981   -23.13536 1.000 48.21646  ? 170 THR B CB  1 
ATOM   2066 O  OG1 . THR B 1 77  ? 14.90264  3.23422   -24.46306 1.000 53.10933  ? 170 THR B OG1 1 
ATOM   2067 C  CG2 . THR B 1 77  ? 14.27526  4.50210   -22.52310 1.000 40.43303  ? 170 THR B CG2 1 
ATOM   2068 N  N   . GLU B 1 78  ? 18.46831  3.35116   -24.60618 1.000 40.51300  ? 171 GLU B N   1 
ATOM   2069 C  CA  . GLU B 1 78  ? 19.48575  2.36553   -24.95864 1.000 46.30728  ? 171 GLU B CA  1 
ATOM   2070 C  C   . GLU B 1 78  ? 20.84444  2.77966   -24.39471 1.000 43.96610  ? 171 GLU B C   1 
ATOM   2071 O  O   . GLU B 1 78  ? 21.27669  3.92457   -24.57051 1.000 43.30072  ? 171 GLU B O   1 
ATOM   2072 C  CB  . GLU B 1 78  ? 19.57446  2.19483   -26.48135 1.000 39.95412  ? 171 GLU B CB  1 
ATOM   2073 C  CG  . GLU B 1 78  ? 20.57611  1.12078   -26.90312 1.000 39.50429  ? 171 GLU B CG  1 
ATOM   2074 C  CD  . GLU B 1 78  ? 20.76035  1.00485   -28.41459 1.000 50.62805  ? 171 GLU B CD  1 
ATOM   2075 O  OE1 . GLU B 1 78  ? 19.78249  1.22272   -29.16491 1.000 59.68337  ? 171 GLU B OE1 1 
ATOM   2076 O  OE2 . GLU B 1 78  ? 21.88648  0.68952   -28.85515 1.000 49.74806  ? 171 GLU B OE2 1 
ATOM   2077 N  N   . VAL B 1 79  ? 21.51466  1.83823   -23.72850 1.000 40.80065  ? 172 VAL B N   1 
ATOM   2078 C  CA  . VAL B 1 79  ? 22.82441  2.09503   -23.13857 1.000 38.66756  ? 172 VAL B CA  1 
ATOM   2079 C  C   . VAL B 1 79  ? 23.83545  2.39174   -24.23611 1.000 40.99473  ? 172 VAL B C   1 
ATOM   2080 O  O   . VAL B 1 79  ? 23.91913  1.66445   -25.23310 1.000 36.08906  ? 172 VAL B O   1 
ATOM   2081 C  CB  . VAL B 1 79  ? 23.26236  0.88722   -22.29479 1.000 36.40719  ? 172 VAL B CB  1 
ATOM   2082 C  CG1 . VAL B 1 79  ? 24.70616  1.03780   -21.85591 1.000 41.18029  ? 172 VAL B CG1 1 
ATOM   2083 C  CG2 . VAL B 1 79  ? 22.36429  0.73324   -21.08551 1.000 42.83023  ? 172 VAL B CG2 1 
ATOM   2084 N  N   . VAL B 1 80  ? 24.59006  3.47995   -24.07582 1.000 40.91678  ? 173 VAL B N   1 
ATOM   2085 C  CA  . VAL B 1 80  ? 25.67862  3.78875   -25.00014 1.000 36.19496  ? 173 VAL B CA  1 
ATOM   2086 C  C   . VAL B 1 80  ? 26.87215  2.93042   -24.61925 1.000 30.25999  ? 173 VAL B C   1 
ATOM   2087 O  O   . VAL B 1 80  ? 27.37903  3.02639   -23.49676 1.000 37.76601  ? 173 VAL B O   1 
ATOM   2088 C  CB  . VAL B 1 80  ? 26.06447  5.27829   -24.96306 1.000 39.52214  ? 173 VAL B CB  1 
ATOM   2089 C  CG1 . VAL B 1 80  ? 27.28363  5.48906   -25.84290 1.000 32.53113  ? 173 VAL B CG1 1 
ATOM   2090 C  CG2 . VAL B 1 80  ? 24.93891  6.16575   -25.44722 1.000 35.88865  ? 173 VAL B CG2 1 
ATOM   2091 N  N   . ARG B 1 81  ? 27.34232  2.10873   -25.55065 1.000 36.53585  ? 174 ARG B N   1 
ATOM   2092 C  CA  . ARG B 1 81  ? 28.49628  1.26258   -25.28004 1.000 33.64897  ? 174 ARG B CA  1 
ATOM   2093 C  C   . ARG B 1 81  ? 29.32599  1.15277   -26.54916 1.000 33.81716  ? 174 ARG B C   1 
ATOM   2094 O  O   . ARG B 1 81  ? 28.90241  1.57998   -27.62083 1.000 38.10613  ? 174 ARG B O   1 
ATOM   2095 C  CB  . ARG B 1 81  ? 28.06962  -0.12606  -24.74885 1.000 46.82563  ? 174 ARG B CB  1 
ATOM   2096 C  CG  . ARG B 1 81  ? 26.87576  -0.78171  -25.47174 1.000 42.56367  ? 174 ARG B CG  1 
ATOM   2097 C  CD  . ARG B 1 81  ? 26.58339  -2.19802  -24.90801 1.000 59.27543  ? 174 ARG B CD  1 
ATOM   2098 N  NE  . ARG B 1 81  ? 25.46516  -2.24765  -23.96740 1.000 52.85115  ? 174 ARG B NE  1 
ATOM   2099 C  CZ  . ARG B 1 81  ? 25.57428  -2.64014  -22.70438 1.000 53.17991  ? 174 ARG B CZ  1 
ATOM   2100 N  NH1 . ARG B 1 81  ? 26.74887  -2.95324  -22.18176 1.000 53.69775  ? 174 ARG B NH1 1 
ATOM   2101 N  NH2 . ARG B 1 81  ? 24.47961  -2.71371  -21.94430 1.000 50.66481  ? 174 ARG B NH2 1 
ATOM   2102 N  N   . ARG B 1 82  ? 30.53703  0.61440   -26.41060 1.000 35.83444  ? 175 ARG B N   1 
ATOM   2103 C  CA  . ARG B 1 82  ? 31.38198  0.35659   -27.56974 1.000 37.94557  ? 175 ARG B CA  1 
ATOM   2104 C  C   . ARG B 1 82  ? 30.83516  -0.79546  -28.39915 1.000 42.62057  ? 175 ARG B C   1 
ATOM   2105 O  O   . ARG B 1 82  ? 30.17622  -1.69455  -27.88571 1.000 40.01236  ? 175 ARG B O   1 
ATOM   2106 C  CB  . ARG B 1 82  ? 32.79782  0.00699   -27.14156 1.000 41.04317  ? 175 ARG B CB  1 
ATOM   2107 C  CG  . ARG B 1 82  ? 33.59405  1.19763   -26.71200 1.000 40.70404  ? 175 ARG B CG  1 
ATOM   2108 C  CD  . ARG B 1 82  ? 34.94576  0.75152   -26.25009 1.000 39.50010  ? 175 ARG B CD  1 
ATOM   2109 N  NE  . ARG B 1 82  ? 35.94238  0.74201   -27.31144 1.000 38.49256  ? 175 ARG B NE  1 
ATOM   2110 C  CZ  . ARG B 1 82  ? 37.16914  0.26840   -27.14917 1.000 42.63645  ? 175 ARG B CZ  1 
ATOM   2111 N  NH1 . ARG B 1 82  ? 37.52045  -0.37020  -26.04153 1.000 40.21516  ? 175 ARG B NH1 1 
ATOM   2112 N  NH2 . ARG B 1 82  ? 38.07292  0.46444   -28.10426 1.000 41.76199  ? 175 ARG B NH2 1 
ATOM   2113 N  N   . CYS B 1 83  ? 31.17072  -0.78663  -29.68676 1.000 44.05203  ? 176 CYS B N   1 
ATOM   2114 C  CA  . CYS B 1 83  ? 30.65389  -1.76671  -30.61898 1.000 40.81951  ? 176 CYS B CA  1 
ATOM   2115 C  C   . CYS B 1 83  ? 31.33310  -3.11985  -30.39903 1.000 43.92485  ? 176 CYS B C   1 
ATOM   2116 O  O   . CYS B 1 83  ? 32.35175  -3.20745  -29.70273 1.000 41.32090  ? 176 CYS B O   1 
ATOM   2117 C  CB  . CYS B 1 83  ? 30.84538  -1.26092  -32.05333 1.000 35.63763  ? 176 CYS B CB  1 
ATOM   2118 S  SG  . CYS B 1 83  ? 32.50835  -1.34647  -32.67426 1.000 41.15249  ? 176 CYS B SG  1 
ATOM   2119 N  N   . PRO B 1 84  ? 30.76211  -4.19901  -30.95585 1.000 46.93127  ? 177 PRO B N   1 
ATOM   2120 C  CA  . PRO B 1 84  ? 31.36891  -5.52953  -30.77443 1.000 44.26619  ? 177 PRO B CA  1 
ATOM   2121 C  C   . PRO B 1 84  ? 32.81559  -5.63574  -31.22607 1.000 43.32189  ? 177 PRO B C   1 
ATOM   2122 O  O   . PRO B 1 84  ? 33.58030  -6.40548  -30.63352 1.000 50.38041  ? 177 PRO B O   1 
ATOM   2123 C  CB  . PRO B 1 84  ? 30.45541  -6.42036  -31.62000 1.000 48.94877  ? 177 PRO B CB  1 
ATOM   2124 C  CG  . PRO B 1 84  ? 29.14769  -5.78300  -31.48473 1.000 41.90764  ? 177 PRO B CG  1 
ATOM   2125 C  CD  . PRO B 1 84  ? 29.42680  -4.32396  -31.57239 1.000 47.41287  ? 177 PRO B CD  1 
ATOM   2126 N  N   A HIS B 1 85  ? 33.21793  -4.89022  -32.25986 0.500 43.16480  ? 178 HIS B N   1 
ATOM   2127 N  N   B HIS B 1 85  ? 33.22745  -4.87455  -32.23270 0.500 43.17237  ? 178 HIS B N   1 
ATOM   2128 C  CA  A HIS B 1 85  ? 34.58884  -4.97712  -32.74974 0.500 39.82400  ? 178 HIS B CA  1 
ATOM   2129 C  CA  B HIS B 1 85  ? 34.59592  -5.00827  -32.70730 0.500 39.81674  ? 178 HIS B CA  1 
ATOM   2130 C  C   A HIS B 1 85  ? 35.55967  -4.20637  -31.86040 0.500 44.98943  ? 178 HIS B C   1 
ATOM   2131 C  C   B HIS B 1 85  ? 35.57542  -4.19646  -31.86889 0.500 44.98868  ? 178 HIS B C   1 
ATOM   2132 O  O   A HIS B 1 85  ? 36.62133  -4.72802  -31.49917 0.500 45.84384  ? 178 HIS B O   1 
ATOM   2133 O  O   B HIS B 1 85  ? 36.65355  -4.69789  -31.52676 0.500 45.86126  ? 178 HIS B O   1 
ATOM   2134 C  CB  A HIS B 1 85  ? 34.66197  -4.47370  -34.19470 0.500 44.55975  ? 178 HIS B CB  1 
ATOM   2135 C  CB  B HIS B 1 85  ? 34.64679  -4.63109  -34.18126 0.500 44.56168  ? 178 HIS B CB  1 
ATOM   2136 C  CG  A HIS B 1 85  ? 36.03283  -4.03676  -34.61560 0.500 47.13883  ? 178 HIS B CG  1 
ATOM   2137 C  CG  B HIS B 1 85  ? 33.71361  -5.44822  -35.01689 0.500 46.34390  ? 178 HIS B CG  1 
ATOM   2138 N  ND1 A HIS B 1 85  ? 37.00750  -4.92153  -35.03105 0.500 51.91150  ? 178 HIS B ND1 1 
ATOM   2139 N  ND1 B HIS B 1 85  ? 33.51010  -6.79509  -34.79382 0.500 42.42607  ? 178 HIS B ND1 1 
ATOM   2140 C  CD2 A HIS B 1 85  ? 36.58755  -2.80325  -34.69150 0.500 51.73889  ? 178 HIS B CD2 1 
ATOM   2141 C  CD2 B HIS B 1 85  ? 32.90194  -5.10975  -36.04602 0.500 49.31137  ? 178 HIS B CD2 1 
ATOM   2142 C  CE1 A HIS B 1 85  ? 38.10395  -4.25160  -35.34117 0.500 54.82720  ? 178 HIS B CE1 1 
ATOM   2143 C  CE1 B HIS B 1 85  ? 32.62503  -7.25373  -35.66016 0.500 44.86980  ? 178 HIS B CE1 1 
ATOM   2144 N  NE2 A HIS B 1 85  ? 37.87619  -2.96483  -35.14094 0.500 57.37506  ? 178 HIS B NE2 1 
ATOM   2145 N  NE2 B HIS B 1 85  ? 32.24294  -6.25273  -36.43357 0.500 46.47727  ? 178 HIS B NE2 1 
ATOM   2146 N  N   . HIS B 1 86  ? 35.21228  -2.96416  -31.48859 1.000 41.51200  ? 179 HIS B N   1 
ATOM   2147 C  CA  . HIS B 1 86  ? 36.13914  -2.14713  -30.69864 1.000 40.80745  ? 179 HIS B CA  1 
ATOM   2148 C  C   . HIS B 1 86  ? 36.31157  -2.68071  -29.27902 1.000 37.77272  ? 179 HIS B C   1 
ATOM   2149 O  O   . HIS B 1 86  ? 37.39683  -2.54977  -28.70013 1.000 39.85296  ? 179 HIS B O   1 
ATOM   2150 C  CB  . HIS B 1 86  ? 35.69223  -0.67971  -30.67540 1.000 40.22936  ? 179 HIS B CB  1 
ATOM   2151 C  CG  . HIS B 1 86  ? 36.14133  0.09736   -31.87621 1.000 45.77267  ? 179 HIS B CG  1 
ATOM   2152 N  ND1 . HIS B 1 86  ? 35.25732  0.65011   -32.77798 1.000 36.39467  ? 179 HIS B ND1 1 
ATOM   2153 C  CD2 . HIS B 1 86  ? 37.38183  0.39222   -32.33926 1.000 44.06171  ? 179 HIS B CD2 1 
ATOM   2154 C  CE1 . HIS B 1 86  ? 35.92675  1.25674   -33.74162 1.000 42.81102  ? 179 HIS B CE1 1 
ATOM   2155 N  NE2 . HIS B 1 86  ? 37.21925  1.12038   -33.49735 1.000 45.20433  ? 179 HIS B NE2 1 
ATOM   2156 N  N   . GLU B 1 87  ? 35.28422  -3.31153  -28.70823 1.000 35.85438  ? 180 GLU B N   1 
ATOM   2157 C  CA  . GLU B 1 87  ? 35.46949  -3.90212  -27.38522 1.000 40.23079  ? 180 GLU B CA  1 
ATOM   2158 C  C   . GLU B 1 87  ? 36.49823  -5.03850  -27.38248 1.000 37.07155  ? 180 GLU B C   1 
ATOM   2159 O  O   . GLU B 1 87  ? 37.03928  -5.36231  -26.32078 1.000 41.19203  ? 180 GLU B O   1 
ATOM   2160 C  CB  . GLU B 1 87  ? 34.12899  -4.38655  -26.82702 1.000 39.56465  ? 180 GLU B CB  1 
ATOM   2161 C  CG  . GLU B 1 87  ? 33.63538  -5.71708  -27.38537 1.000 46.67697  ? 180 GLU B CG  1 
ATOM   2162 C  CD  . GLU B 1 87  ? 32.41198  -6.25320  -26.64696 1.000 49.83356  ? 180 GLU B CD  1 
ATOM   2163 O  OE1 . GLU B 1 87  ? 31.81169  -5.50441  -25.83020 1.000 44.49043  ? 180 GLU B OE1 1 
ATOM   2164 O  OE2 . GLU B 1 87  ? 32.06617  -7.43599  -26.87153 1.000 51.83192  ? 180 GLU B OE2 1 
ATOM   2165 N  N   . ARG B 1 88  ? 36.81247  -5.62636  -28.53599 1.000 45.56290  ? 181 ARG B N   1 
ATOM   2166 C  CA  . ARG B 1 88  ? 37.83199  -6.67043  -28.59807 1.000 44.86890  ? 181 ARG B CA  1 
ATOM   2167 C  C   . ARG B 1 88  ? 39.20972  -6.14089  -28.95932 1.000 48.38269  ? 181 ARG B C   1 
ATOM   2168 O  O   . ARG B 1 88  ? 40.16588  -6.91934  -28.98599 1.000 57.10176  ? 181 ARG B O   1 
ATOM   2169 C  CB  . ARG B 1 88  ? 37.41597  -7.76027  -29.59477 1.000 42.72266  ? 181 ARG B CB  1 
ATOM   2170 C  CG  . ARG B 1 88  ? 36.11312  -8.42527  -29.19513 1.000 39.59736  ? 181 ARG B CG  1 
ATOM   2171 C  CD  . ARG B 1 88  ? 35.70797  -9.54119  -30.13326 1.000 42.01682  ? 181 ARG B CD  1 
ATOM   2172 N  NE  . ARG B 1 88  ? 36.57540  -10.70718 -30.02509 1.000 46.24950  ? 181 ARG B NE  1 
ATOM   2173 C  CZ  . ARG B 1 88  ? 37.20570  -11.26861 -31.04929 1.000 45.61682  ? 181 ARG B CZ  1 
ATOM   2174 N  NH1 . ARG B 1 88  ? 37.15348  -10.74772 -32.26844 1.000 41.49358  ? 181 ARG B NH1 1 
ATOM   2175 N  NH2 . ARG B 1 88  ? 37.89702  -12.38522 -30.84883 1.000 33.90153  ? 181 ARG B NH2 1 
ATOM   2176 N  N   . CYS B 1 89  ? 39.33422  -4.84791  -29.24080 1.000 48.39582  ? 182 CYS B N   1 
ATOM   2177 C  CA  . CYS B 1 89  ? 40.64499  -4.25402  -29.46702 1.000 53.22629  ? 182 CYS B CA  1 
ATOM   2178 C  C   . CYS B 1 89  ? 41.50483  -4.39135  -28.21889 1.000 54.99911  ? 182 CYS B C   1 
ATOM   2179 O  O   . CYS B 1 89  ? 41.03002  -4.21536  -27.09276 1.000 59.31595  ? 182 CYS B O   1 
ATOM   2180 C  CB  . CYS B 1 89  ? 40.50006  -2.77637  -29.84769 1.000 48.55457  ? 182 CYS B CB  1 
ATOM   2181 S  SG  . CYS B 1 89  ? 40.32982  -2.54824  -31.61712 1.000 62.96413  ? 182 CYS B SG  1 
ATOM   2182 N  N   . SER B 1 90  ? 42.77228  -4.74403  -28.41783 1.000 57.17441  ? 183 SER B N   1 
ATOM   2183 C  CA  . SER B 1 90  ? 43.71052  -4.84360  -27.30274 1.000 57.81713  ? 183 SER B CA  1 
ATOM   2184 C  C   . SER B 1 90  ? 44.23991  -3.43573  -27.06304 1.000 64.54039  ? 183 SER B C   1 
ATOM   2185 O  O   . SER B 1 90  ? 45.27232  -3.02190  -27.59791 1.000 61.72852  ? 183 SER B O   1 
ATOM   2186 C  CB  . SER B 1 90  ? 44.82304  -5.84361  -27.60608 1.000 64.99722  ? 183 SER B CB  1 
ATOM   2187 N  N   . ASP B 1 91  ? 43.46505  -2.65802  -26.29085 1.000 61.04319  ? 184 ASP B N   1 
ATOM   2188 C  CA  . ASP B 1 91  ? 43.79156  -1.24936  -26.10623 1.000 60.71954  ? 184 ASP B CA  1 
ATOM   2189 C  C   . ASP B 1 91  ? 43.50739  -0.75606  -24.69022 1.000 59.79009  ? 184 ASP B C   1 
ATOM   2190 O  O   . ASP B 1 91  ? 43.27522  0.44271   -24.49187 1.000 59.53304  ? 184 ASP B O   1 
ATOM   2191 C  CB  . ASP B 1 91  ? 43.05436  -0.35021  -27.12359 1.000 58.16119  ? 184 ASP B CB  1 
ATOM   2192 C  CG  . ASP B 1 91  ? 41.51135  -0.46485  -27.06932 1.000 61.13713  ? 184 ASP B CG  1 
ATOM   2193 O  OD1 . ASP B 1 91  ? 40.87185  0.02351   -28.04289 1.000 49.06810  ? 184 ASP B OD1 1 
ATOM   2194 O  OD2 . ASP B 1 91  ? 40.93177  -0.98737  -26.08295 1.000 49.65924  ? 184 ASP B OD2 1 
ATOM   2195 N  N   . SER B 1 92  ? 43.52211  -1.64283  -23.69654 1.000 58.75418  ? 185 SER B N   1 
ATOM   2196 C  CA  . SER B 1 92  ? 43.25762  -1.20963  -22.32991 1.000 67.25458  ? 185 SER B CA  1 
ATOM   2197 C  C   . SER B 1 92  ? 44.37959  -0.30292  -21.82235 1.000 62.98713  ? 185 SER B C   1 
ATOM   2198 O  O   . SER B 1 92  ? 45.52775  -0.38385  -22.26619 1.000 63.42252  ? 185 SER B O   1 
ATOM   2199 C  CB  . SER B 1 92  ? 43.09099  -2.41925  -21.40362 1.000 60.35753  ? 185 SER B CB  1 
ATOM   2200 O  OG  . SER B 1 92  ? 43.74195  -2.21719  -20.15895 1.000 62.00566  ? 185 SER B OG  1 
ATOM   2201 N  N   . ASP B 1 93  ? 44.02571  0.59628   -20.90797 1.000 64.20296  ? 186 ASP B N   1 
ATOM   2202 C  CA  . ASP B 1 93  ? 45.00081  1.38658   -20.16999 1.000 59.71104  ? 186 ASP B CA  1 
ATOM   2203 C  C   . ASP B 1 93  ? 45.23976  0.82027   -18.77494 1.000 67.07991  ? 186 ASP B C   1 
ATOM   2204 O  O   . ASP B 1 93  ? 45.81564  1.50044   -17.91913 1.000 73.73469  ? 186 ASP B O   1 
ATOM   2205 C  CB  . ASP B 1 93  ? 44.55551  2.85312   -20.09255 1.000 66.84576  ? 186 ASP B CB  1 
ATOM   2206 C  CG  . ASP B 1 93  ? 43.13780  3.02783   -19.53211 1.000 67.63767  ? 186 ASP B CG  1 
ATOM   2207 O  OD1 . ASP B 1 93  ? 42.55180  4.11126   -19.76157 1.000 63.72706  ? 186 ASP B OD1 1 
ATOM   2208 O  OD2 . ASP B 1 93  ? 42.60802  2.10842   -18.85632 1.000 64.21400  ? 186 ASP B OD2 1 
ATOM   2209 N  N   . GLY B 1 94  ? 44.77619  -0.39963  -18.52412 1.000 58.35661  ? 187 GLY B N   1 
ATOM   2210 C  CA  . GLY B 1 94  ? 44.85234  -1.00181  -17.21782 1.000 67.60792  ? 187 GLY B CA  1 
ATOM   2211 C  C   . GLY B 1 94  ? 43.73436  -0.61182  -16.28404 1.000 70.64567  ? 187 GLY B C   1 
ATOM   2212 O  O   . GLY B 1 94  ? 43.55568  -1.26806  -15.24943 1.000 65.02820  ? 187 GLY B O   1 
ATOM   2213 N  N   . LEU B 1 95  ? 42.95981  0.41172   -16.62009 1.000 62.57439  ? 188 LEU B N   1 
ATOM   2214 C  CA  . LEU B 1 95  ? 41.92811  0.91152   -15.72845 1.000 56.23382  ? 188 LEU B CA  1 
ATOM   2215 C  C   . LEU B 1 95  ? 40.53254  0.86265   -16.32064 1.000 55.83800  ? 188 LEU B C   1 
ATOM   2216 O  O   . LEU B 1 95  ? 39.58504  0.51360   -15.61163 1.000 52.77474  ? 188 LEU B O   1 
ATOM   2217 C  CB  . LEU B 1 95  ? 42.24879  2.34843   -15.32007 1.000 59.23213  ? 188 LEU B CB  1 
ATOM   2218 C  CG  . LEU B 1 95  ? 42.72908  2.50700   -13.88664 1.000 68.56692  ? 188 LEU B CG  1 
ATOM   2219 C  CD1 . LEU B 1 95  ? 42.47424  3.94278   -13.45382 1.000 55.43242  ? 188 LEU B CD1 1 
ATOM   2220 C  CD2 . LEU B 1 95  ? 42.05079  1.48744   -12.94820 1.000 58.47044  ? 188 LEU B CD2 1 
ATOM   2221 N  N   . ALA B 1 96  ? 40.37640  1.21097   -17.59582 1.000 49.26016  ? 189 ALA B N   1 
ATOM   2222 C  CA  . ALA B 1 96  ? 39.05327  1.26748   -18.21087 1.000 44.55441  ? 189 ALA B CA  1 
ATOM   2223 C  C   . ALA B 1 96  ? 38.62534  -0.10956  -18.70210 1.000 44.53187  ? 189 ALA B C   1 
ATOM   2224 O  O   . ALA B 1 96  ? 39.38304  -0.76590  -19.41894 1.000 47.12821  ? 189 ALA B O   1 
ATOM   2225 C  CB  . ALA B 1 96  ? 39.04666  2.24088   -19.37271 1.000 44.14439  ? 189 ALA B CB  1 
ATOM   2226 N  N   . PRO B 1 97  ? 37.41796  -0.56527  -18.36107 1.000 45.70761  ? 190 PRO B N   1 
ATOM   2227 C  CA  . PRO B 1 97  ? 36.92437  -1.82159  -18.92968 1.000 42.54992  ? 190 PRO B CA  1 
ATOM   2228 C  C   . PRO B 1 97  ? 36.70383  -1.67560  -20.42311 1.000 41.17871  ? 190 PRO B C   1 
ATOM   2229 O  O   . PRO B 1 97  ? 36.40663  -0.57320  -20.91597 1.000 42.39275  ? 190 PRO B O   1 
ATOM   2230 C  CB  . PRO B 1 97  ? 35.59298  -2.04926  -18.18680 1.000 39.49844  ? 190 PRO B CB  1 
ATOM   2231 C  CG  . PRO B 1 97  ? 35.65216  -1.13572  -16.97794 1.000 40.91657  ? 190 PRO B CG  1 
ATOM   2232 C  CD  . PRO B 1 97  ? 36.42173  0.06066   -17.48291 1.000 43.20654  ? 190 PRO B CD  1 
ATOM   2233 N  N   . PRO B 1 98  ? 36.82817  -2.76450  -21.18769 1.000 41.39776  ? 191 PRO B N   1 
ATOM   2234 C  CA  . PRO B 1 98  ? 36.85124  -2.63368  -22.65557 1.000 39.83889  ? 191 PRO B CA  1 
ATOM   2235 C  C   . PRO B 1 98  ? 35.52553  -2.21659  -23.29028 1.000 37.63358  ? 191 PRO B C   1 
ATOM   2236 O  O   . PRO B 1 98  ? 35.53650  -1.81470  -24.45959 1.000 38.70842  ? 191 PRO B O   1 
ATOM   2237 C  CB  . PRO B 1 98  ? 37.27707  -4.03727  -23.12623 1.000 38.34861  ? 191 PRO B CB  1 
ATOM   2238 C  CG  . PRO B 1 98  ? 37.84022  -4.70760  -21.90377 1.000 49.53366  ? 191 PRO B CG  1 
ATOM   2239 C  CD  . PRO B 1 98  ? 37.05975  -4.15521  -20.75692 1.000 45.24711  ? 191 PRO B CD  1 
ATOM   2240 N  N   . GLN B 1 99  ? 34.39282  -2.29325  -22.58549 1.000 37.14835  ? 192 GLN B N   1 
ATOM   2241 C  CA  . GLN B 1 99  ? 33.10553  -1.92220  -23.17240 1.000 34.24880  ? 192 GLN B CA  1 
ATOM   2242 C  C   . GLN B 1 99  ? 32.78457  -0.43286  -23.04945 1.000 40.39198  ? 192 GLN B C   1 
ATOM   2243 O  O   . GLN B 1 99  ? 31.79213  0.02245   -23.62675 1.000 38.93248  ? 192 GLN B O   1 
ATOM   2244 C  CB  . GLN B 1 99  ? 31.96760  -2.70591  -22.50763 1.000 33.28912  ? 192 GLN B CB  1 
ATOM   2245 C  CG  . GLN B 1 99  ? 32.13680  -4.23493  -22.51362 1.000 44.03195  ? 192 GLN B CG  1 
ATOM   2246 C  CD  . GLN B 1 99  ? 32.81693  -4.75303  -21.25234 1.000 55.07975  ? 192 GLN B CD  1 
ATOM   2247 O  OE1 . GLN B 1 99  ? 33.68693  -4.08460  -20.67856 1.000 60.22551  ? 192 GLN B OE1 1 
ATOM   2248 N  NE2 . GLN B 1 99  ? 32.41640  -5.93772  -20.80499 1.000 60.25841  ? 192 GLN B NE2 1 
ATOM   2249 N  N   . HIS B 1 100 ? 33.57281  0.32241   -22.29156 1.000 38.48100  ? 193 HIS B N   1 
ATOM   2250 C  CA  . HIS B 1 100 ? 33.23084  1.69580   -21.95568 1.000 40.26791  ? 193 HIS B CA  1 
ATOM   2251 C  C   . HIS B 1 100 ? 33.60656  2.62593   -23.09845 1.000 37.43210  ? 193 HIS B C   1 
ATOM   2252 O  O   . HIS B 1 100 ? 34.76128  2.64418   -23.53310 1.000 36.08040  ? 193 HIS B O   1 
ATOM   2253 C  CB  . HIS B 1 100 ? 33.95222  2.12358   -20.68298 1.000 30.37800  ? 193 HIS B CB  1 
ATOM   2254 C  CG  . HIS B 1 100 ? 33.26030  1.71271   -19.42411 1.000 37.98097  ? 193 HIS B CG  1 
ATOM   2255 N  ND1 . HIS B 1 100 ? 33.15397  2.54569   -18.33350 1.000 44.34858  ? 193 HIS B ND1 1 
ATOM   2256 C  CD2 . HIS B 1 100 ? 32.63819  0.56101   -19.07846 1.000 45.10900  ? 193 HIS B CD2 1 
ATOM   2257 C  CE1 . HIS B 1 100 ? 32.49703  1.92737   -17.36881 1.000 43.90923  ? 193 HIS B CE1 1 
ATOM   2258 N  NE2 . HIS B 1 100 ? 32.17397  0.71994   -17.79347 1.000 38.39456  ? 193 HIS B NE2 1 
ATOM   2259 N  N   . LEU B 1 101 ? 32.62938  3.40762   -23.57019 1.000 36.46551  ? 194 LEU B N   1 
ATOM   2260 C  CA  . LEU B 1 101 ? 32.88798  4.39277   -24.61857 1.000 32.32855  ? 194 LEU B CA  1 
ATOM   2261 C  C   . LEU B 1 101 ? 33.82627  5.49709   -24.14300 1.000 40.10234  ? 194 LEU B C   1 
ATOM   2262 O  O   . LEU B 1 101 ? 34.77298  5.86108   -24.85173 1.000 40.00997  ? 194 LEU B O   1 
ATOM   2263 C  CB  . LEU B 1 101 ? 31.57554  5.00643   -25.09901 1.000 38.10228  ? 194 LEU B CB  1 
ATOM   2264 C  CG  . LEU B 1 101 ? 31.81879  6.16442   -26.07214 1.000 39.11518  ? 194 LEU B CG  1 
ATOM   2265 C  CD1 . LEU B 1 101 ? 32.42727  5.61333   -27.34185 1.000 37.92591  ? 194 LEU B CD1 1 
ATOM   2266 C  CD2 . LEU B 1 101 ? 30.56204  6.97371   -26.39271 1.000 37.08168  ? 194 LEU B CD2 1 
ATOM   2267 N  N   . ILE B 1 102 ? 33.57064  6.06196   -22.95501 1.000 34.56078  ? 195 ILE B N   1 
ATOM   2268 C  CA  . ILE B 1 102 ? 34.28039  7.25167   -22.48356 1.000 35.67527  ? 195 ILE B CA  1 
ATOM   2269 C  C   . ILE B 1 102 ? 35.39036  6.84541   -21.52899 1.000 38.20997  ? 195 ILE B C   1 
ATOM   2270 O  O   . ILE B 1 102 ? 35.14504  6.15097   -20.53788 1.000 36.80753  ? 195 ILE B O   1 
ATOM   2271 C  CB  . ILE B 1 102 ? 33.33475  8.23731   -21.78130 1.000 36.43451  ? 195 ILE B CB  1 
ATOM   2272 C  CG1 . ILE B 1 102 ? 32.22466  8.72120   -22.71712 1.000 35.62602  ? 195 ILE B CG1 1 
ATOM   2273 C  CG2 . ILE B 1 102 ? 34.14147  9.39904   -21.22664 1.000 35.59276  ? 195 ILE B CG2 1 
ATOM   2274 C  CD1 . ILE B 1 102 ? 31.22931  9.65486   -22.00860 1.000 37.97497  ? 195 ILE B CD1 1 
ATOM   2275 N  N   . ARG B 1 103 ? 36.59783  7.31844   -21.78656 1.000 37.19981  ? 196 ARG B N   1 
ATOM   2276 C  CA  . ARG B 1 103 ? 37.69942  7.09894   -20.87009 1.000 35.12816  ? 196 ARG B CA  1 
ATOM   2277 C  C   . ARG B 1 103 ? 38.19383  8.43429   -20.34049 1.000 40.21415  ? 196 ARG B C   1 
ATOM   2278 O  O   . ARG B 1 103 ? 38.05679  9.47536   -20.99883 1.000 38.31100  ? 196 ARG B O   1 
ATOM   2279 C  CB  . ARG B 1 103 ? 38.84213  6.36743   -21.55914 1.000 37.62717  ? 196 ARG B CB  1 
ATOM   2280 C  CG  . ARG B 1 103 ? 38.51628  4.94542   -21.89045 1.000 37.09122  ? 196 ARG B CG  1 
ATOM   2281 C  CD  . ARG B 1 103 ? 39.76807  4.21317   -22.25797 1.000 44.79628  ? 196 ARG B CD  1 
ATOM   2282 N  NE  . ARG B 1 103 ? 39.45453  2.95901   -22.92156 1.000 43.90242  ? 196 ARG B NE  1 
ATOM   2283 C  CZ  . ARG B 1 103 ? 40.35407  2.18361   -23.50718 1.000 53.58747  ? 196 ARG B CZ  1 
ATOM   2284 N  NH1 . ARG B 1 103 ? 41.63911  2.49873   -23.51214 1.000 51.17890  ? 196 ARG B NH1 1 
ATOM   2285 N  NH2 . ARG B 1 103 ? 39.95582  1.06137   -24.09503 1.000 52.95281  ? 196 ARG B NH2 1 
ATOM   2286 N  N   . VAL B 1 104 ? 38.75354  8.40628   -19.13517 1.000 42.98374  ? 197 VAL B N   1 
ATOM   2287 C  CA  . VAL B 1 104 ? 39.54808  9.51707   -18.62866 1.000 42.21522  ? 197 VAL B CA  1 
ATOM   2288 C  C   . VAL B 1 104 ? 41.00993  9.15786   -18.81832 1.000 50.27810  ? 197 VAL B C   1 
ATOM   2289 O  O   . VAL B 1 104 ? 41.43802  8.05108   -18.46454 1.000 48.48083  ? 197 VAL B O   1 
ATOM   2290 C  CB  . VAL B 1 104 ? 39.23853  9.81403   -17.15545 1.000 47.91806  ? 197 VAL B CB  1 
ATOM   2291 C  CG1 . VAL B 1 104 ? 40.31522  10.70565  -16.56447 1.000 44.56210  ? 197 VAL B CG1 1 
ATOM   2292 C  CG2 . VAL B 1 104 ? 37.89483  10.48770  -17.04139 1.000 41.12643  ? 197 VAL B CG2 1 
ATOM   2293 N  N   . GLU B 1 105 ? 41.76916  10.07536  -19.39921 1.000 48.05683  ? 198 GLU B N   1 
ATOM   2294 C  CA  . GLU B 1 105 ? 43.19004  9.87796   -19.61682 1.000 49.62647  ? 198 GLU B CA  1 
ATOM   2295 C  C   . GLU B 1 105 ? 44.00152  10.58713  -18.53944 1.000 55.24953  ? 198 GLU B C   1 
ATOM   2296 O  O   . GLU B 1 105 ? 43.63498  11.67218  -18.08280 1.000 49.10612  ? 198 GLU B O   1 
ATOM   2297 C  CB  . GLU B 1 105 ? 43.58401  10.38937  -20.99951 1.000 53.43397  ? 198 GLU B CB  1 
ATOM   2298 C  CG  . GLU B 1 105 ? 44.92019  9.87989   -21.47808 1.000 63.53045  ? 198 GLU B CG  1 
ATOM   2299 C  CD  . GLU B 1 105 ? 45.12326  10.11967  -22.95770 1.000 77.67214  ? 198 GLU B CD  1 
ATOM   2300 O  OE1 . GLU B 1 105 ? 44.59575  11.13748  -23.47574 1.000 68.21331  ? 198 GLU B OE1 1 
ATOM   2301 O  OE2 . GLU B 1 105 ? 45.81898  9.29350   -23.59711 1.000 70.71901  ? 198 GLU B OE2 1 
ATOM   2302 N  N   . GLY B 1 106 ? 45.09407  9.95529   -18.12137 1.000 56.02475  ? 199 GLY B N   1 
ATOM   2303 C  CA  . GLY B 1 106 ? 46.05237  10.61951  -17.25852 1.000 62.22179  ? 199 GLY B CA  1 
ATOM   2304 C  C   . GLY B 1 106 ? 45.59333  10.89282  -15.84358 1.000 67.00282  ? 199 GLY B C   1 
ATOM   2305 O  O   . GLY B 1 106 ? 46.06339  11.85320  -15.22402 1.000 65.51125  ? 199 GLY B O   1 
ATOM   2306 N  N   . ASN B 1 107 ? 44.69587  10.07352  -15.30329 1.000 54.95954  ? 200 ASN B N   1 
ATOM   2307 C  CA  . ASN B 1 107 ? 44.30252  10.20447  -13.90494 1.000 51.54785  ? 200 ASN B CA  1 
ATOM   2308 C  C   . ASN B 1 107 ? 44.12475  8.80485   -13.34380 1.000 53.76446  ? 200 ASN B C   1 
ATOM   2309 O  O   . ASN B 1 107 ? 43.17973  8.10176   -13.70441 1.000 49.74352  ? 200 ASN B O   1 
ATOM   2310 C  CB  . ASN B 1 107 ? 43.03127  11.03876  -13.75754 1.000 51.97307  ? 200 ASN B CB  1 
ATOM   2311 C  CG  . ASN B 1 107 ? 42.69242  11.34596  -12.31178 1.000 48.12161  ? 200 ASN B CG  1 
ATOM   2312 O  OD1 . ASN B 1 107 ? 42.92589  10.53448  -11.41708 1.000 41.69025  ? 200 ASN B OD1 1 
ATOM   2313 N  ND2 . ASN B 1 107 ? 42.14328  12.53515  -12.07731 1.000 46.38437  ? 200 ASN B ND2 1 
ATOM   2314 N  N   . LEU B 1 108 ? 45.01164  8.42164   -12.43186 1.000 62.72055  ? 201 LEU B N   1 
ATOM   2315 C  CA  . LEU B 1 108 ? 44.96829  7.08557   -11.85378 1.000 51.67049  ? 201 LEU B CA  1 
ATOM   2316 C  C   . LEU B 1 108 ? 43.94345  6.95145   -10.74205 1.000 47.39018  ? 201 LEU B C   1 
ATOM   2317 O  O   . LEU B 1 108 ? 43.73564  5.84180   -10.24462 1.000 48.85829  ? 201 LEU B O   1 
ATOM   2318 C  CB  . LEU B 1 108 ? 46.34901  6.69674   -11.33102 1.000 57.51782  ? 201 LEU B CB  1 
ATOM   2319 C  CG  . LEU B 1 108 ? 47.48286  6.95108   -12.32856 1.000 62.91593  ? 201 LEU B CG  1 
ATOM   2320 C  CD1 . LEU B 1 108 ? 48.76559  7.29200   -11.59623 1.000 70.80153  ? 201 LEU B CD1 1 
ATOM   2321 C  CD2 . LEU B 1 108 ? 47.67914  5.75186   -13.23924 1.000 56.65396  ? 201 LEU B CD2 1 
ATOM   2322 N  N   . ARG B 1 109 ? 43.30717  8.03731   -10.32517 1.000 46.67380  ? 202 ARG B N   1 
ATOM   2323 C  CA  . ARG B 1 109 ? 42.19663  7.92296   -9.39864  1.000 41.16294  ? 202 ARG B CA  1 
ATOM   2324 C  C   . ARG B 1 109 ? 40.85785  7.81506   -10.12374 1.000 40.45277  ? 202 ARG B C   1 
ATOM   2325 O  O   . ARG B 1 109 ? 39.80510  7.89602   -9.48204  1.000 40.57985  ? 202 ARG B O   1 
ATOM   2326 C  CB  . ARG B 1 109 ? 42.21485  9.09325   -8.41349  1.000 41.70290  ? 202 ARG B CB  1 
ATOM   2327 C  CG  . ARG B 1 109 ? 43.46208  9.10364   -7.52219  1.000 48.66101  ? 202 ARG B CG  1 
ATOM   2328 C  CD  . ARG B 1 109 ? 43.45901  10.27864  -6.53490  1.000 47.91452  ? 202 ARG B CD  1 
ATOM   2329 N  N   . ALA B 1 110 ? 40.88094  7.63000   -11.44411 1.000 45.07941  ? 203 ALA B N   1 
ATOM   2330 C  CA  . ALA B 1 110 ? 39.65868  7.39917   -12.20551 1.000 44.61262  ? 203 ALA B CA  1 
ATOM   2331 C  C   . ALA B 1 110 ? 39.04067  6.04840   -11.86092 1.000 47.36069  ? 203 ALA B C   1 
ATOM   2332 O  O   . ALA B 1 110 ? 39.73394  5.03032   -11.78172 1.000 45.46877  ? 203 ALA B O   1 
ATOM   2333 C  CB  . ALA B 1 110 ? 39.94859  7.44615   -13.70331 1.000 47.21589  ? 203 ALA B CB  1 
ATOM   2334 N  N   . GLU B 1 111 ? 37.72649  6.04568   -11.66475 1.000 39.05478  ? 204 GLU B N   1 
ATOM   2335 C  CA  . GLU B 1 111 ? 36.95957  4.83436   -11.42460 1.000 46.91798  ? 204 GLU B CA  1 
ATOM   2336 C  C   . GLU B 1 111 ? 35.88999  4.71698   -12.49854 1.000 44.89420  ? 204 GLU B C   1 
ATOM   2337 O  O   . GLU B 1 111 ? 35.29987  5.72441   -12.91934 1.000 38.20354  ? 204 GLU B O   1 
ATOM   2338 C  CB  . GLU B 1 111 ? 36.30032  4.83622   -10.03875 1.000 53.32516  ? 204 GLU B CB  1 
ATOM   2339 C  CG  . GLU B 1 111 ? 37.26523  4.94255   -8.85384  1.000 59.50399  ? 204 GLU B CG  1 
ATOM   2340 C  CD  . GLU B 1 111 ? 36.54203  4.95495   -7.50989  1.000 55.61960  ? 204 GLU B CD  1 
ATOM   2341 O  OE1 . GLU B 1 111 ? 37.13759  5.42797   -6.52640  1.000 74.17659  ? 204 GLU B OE1 1 
ATOM   2342 O  OE2 . GLU B 1 111 ? 35.37375  4.51781   -7.43537  1.000 68.28398  ? 204 GLU B OE2 1 
ATOM   2343 N  N   . TYR B 1 112 ? 35.64844  3.48924   -12.94149 1.000 39.53109  ? 205 TYR B N   1 
ATOM   2344 C  CA  . TYR B 1 112 ? 34.67709  3.20918   -13.98741 1.000 36.32452  ? 205 TYR B CA  1 
ATOM   2345 C  C   . TYR B 1 112 ? 33.54799  2.38582   -13.39872 1.000 42.22658  ? 205 TYR B C   1 
ATOM   2346 O  O   . TYR B 1 112 ? 33.79777  1.39689   -12.70173 1.000 43.53209  ? 205 TYR B O   1 
ATOM   2347 C  CB  . TYR B 1 112 ? 35.33019  2.46607   -15.14560 1.000 40.51169  ? 205 TYR B CB  1 
ATOM   2348 C  CG  . TYR B 1 112 ? 36.36200  3.28102   -15.87912 1.000 40.70140  ? 205 TYR B CG  1 
ATOM   2349 C  CD1 . TYR B 1 112 ? 37.67567  3.35880   -15.42037 1.000 42.38592  ? 205 TYR B CD1 1 
ATOM   2350 C  CD2 . TYR B 1 112 ? 36.02781  3.97144   -17.03773 1.000 34.30023  ? 205 TYR B CD2 1 
ATOM   2351 C  CE1 . TYR B 1 112 ? 38.62898  4.10749   -16.10408 1.000 40.21384  ? 205 TYR B CE1 1 
ATOM   2352 C  CE2 . TYR B 1 112 ? 36.97055  4.71657   -17.72621 1.000 37.12639  ? 205 TYR B CE2 1 
ATOM   2353 C  CZ  . TYR B 1 112 ? 38.26273  4.79089   -17.24919 1.000 34.69642  ? 205 TYR B CZ  1 
ATOM   2354 O  OH  . TYR B 1 112 ? 39.18666  5.53288   -17.94203 1.000 34.03736  ? 205 TYR B OH  1 
ATOM   2355 N  N   . LEU B 1 113 ? 32.31417  2.79591   -13.66844 1.000 38.84737  ? 206 LEU B N   1 
ATOM   2356 C  CA  . LEU B 1 113 ? 31.14975  2.19856   -13.03365 1.000 35.63282  ? 206 LEU B CA  1 
ATOM   2357 C  C   . LEU B 1 113 ? 30.23293  1.58309   -14.08298 1.000 42.82380  ? 206 LEU B C   1 
ATOM   2358 O  O   . LEU B 1 113 ? 29.92040  2.22197   -15.09629 1.000 43.64432  ? 206 LEU B O   1 
ATOM   2359 C  CB  . LEU B 1 113 ? 30.39086  3.24052   -12.21120 1.000 36.69632  ? 206 LEU B CB  1 
ATOM   2360 C  CG  . LEU B 1 113 ? 28.94221  2.89422   -11.87254 1.000 34.77781  ? 206 LEU B CG  1 
ATOM   2361 C  CD1 . LEU B 1 113 ? 28.92337  1.80128   -10.84616 1.000 47.34125  ? 206 LEU B CD1 1 
ATOM   2362 C  CD2 . LEU B 1 113 ? 28.16193  4.07214   -11.36913 1.000 38.65205  ? 206 LEU B CD2 1 
ATOM   2363 N  N   . ASP B 1 114 ? 29.82296  0.33302   -13.83832 1.000 42.54143  ? 207 ASP B N   1 
ATOM   2364 C  CA  . ASP B 1 114 ? 28.70875  -0.32565  -14.51977 1.000 45.53236  ? 207 ASP B CA  1 
ATOM   2365 C  C   . ASP B 1 114 ? 27.55241  -0.36371  -13.53182 1.000 48.80337  ? 207 ASP B C   1 
ATOM   2366 O  O   . ASP B 1 114 ? 27.60441  -1.11739  -12.55495 1.000 51.34429  ? 207 ASP B O   1 
ATOM   2367 C  CB  . ASP B 1 114 ? 29.05970  -1.75778  -14.93297 1.000 51.32746  ? 207 ASP B CB  1 
ATOM   2368 C  CG  . ASP B 1 114 ? 29.93857  -1.82307  -16.13665 1.000 56.27237  ? 207 ASP B CG  1 
ATOM   2369 O  OD1 . ASP B 1 114 ? 31.10395  -1.38804  -16.02589 1.000 57.06123  ? 207 ASP B OD1 1 
ATOM   2370 O  OD2 . ASP B 1 114 ? 29.47593  -2.34407  -17.17818 1.000 63.04735  ? 207 ASP B OD2 1 
ATOM   2371 N  N   . ASP B 1 115 ? 26.50721  0.41192   -13.79353 1.000 45.20571  ? 208 ASP B N   1 
ATOM   2372 C  CA  . ASP B 1 115 ? 25.41755  0.55034   -12.83451 1.000 50.50021  ? 208 ASP B CA  1 
ATOM   2373 C  C   . ASP B 1 115 ? 24.59266  -0.73054  -12.74709 1.000 49.54702  ? 208 ASP B C   1 
ATOM   2374 O  O   . ASP B 1 115 ? 24.06590  -1.20756  -13.75780 1.000 52.23323  ? 208 ASP B O   1 
ATOM   2375 C  CB  . ASP B 1 115 ? 24.52542  1.71625   -13.23584 1.000 49.25233  ? 208 ASP B CB  1 
ATOM   2376 C  CG  . ASP B 1 115 ? 23.53091  2.07840   -12.16219 1.000 58.10414  ? 208 ASP B CG  1 
ATOM   2377 O  OD1 . ASP B 1 115 ? 22.56221  1.31081   -11.95745 1.000 58.55621  ? 208 ASP B OD1 1 
ATOM   2378 O  OD2 . ASP B 1 115 ? 23.70811  3.14609   -11.53882 1.000 56.10373  ? 208 ASP B OD2 1 
ATOM   2379 N  N   . ARG B 1 116 ? 24.43514  -1.25111  -11.52106 1.000 55.79778  ? 209 ARG B N   1 
ATOM   2380 C  CA  . ARG B 1 116 ? 23.77868  -2.54439  -11.31433 1.000 58.08916  ? 209 ARG B CA  1 
ATOM   2381 C  C   . ARG B 1 116 ? 22.31510  -2.53099  -11.74557 1.000 56.48310  ? 209 ARG B C   1 
ATOM   2382 O  O   . ARG B 1 116 ? 21.78940  -3.56162  -12.17304 1.000 62.23930  ? 209 ARG B O   1 
ATOM   2383 C  CB  . ARG B 1 116 ? 23.87968  -2.95922  -9.84014  1.000 59.24375  ? 209 ARG B CB  1 
ATOM   2384 C  CG  . ARG B 1 116 ? 25.17405  -3.67573  -9.45952  1.000 49.05851  ? 209 ARG B CG  1 
ATOM   2385 N  N   . ASN B 1 117 ? 21.64262  -1.38778  -11.64113 1.000 59.10631  ? 210 ASN B N   1 
ATOM   2386 C  CA  . ASN B 1 117 ? 20.23524  -1.28118  -12.00792 1.000 55.11664  ? 210 ASN B CA  1 
ATOM   2387 C  C   . ASN B 1 117 ? 19.99954  -0.73731  -13.41358 1.000 56.87936  ? 210 ASN B C   1 
ATOM   2388 O  O   . ASN B 1 117 ? 19.05355  -1.16568  -14.07996 1.000 60.66318  ? 210 ASN B O   1 
ATOM   2389 C  CB  . ASN B 1 117 ? 19.48828  -0.40188  -10.99841 1.000 61.09168  ? 210 ASN B CB  1 
ATOM   2390 C  CG  . ASN B 1 117 ? 19.55373  -0.95203  -9.58545  1.000 68.24514  ? 210 ASN B CG  1 
ATOM   2391 O  OD1 . ASN B 1 117 ? 19.57878  -2.17040  -9.37558  1.000 73.08412  ? 210 ASN B OD1 1 
ATOM   2392 N  ND2 . ASN B 1 117 ? 19.56833  -0.05658  -8.60579  1.000 70.77838  ? 210 ASN B ND2 1 
ATOM   2393 N  N   . THR B 1 118 ? 20.80979  0.20333   -13.89634 1.000 52.19361  ? 211 THR B N   1 
ATOM   2394 C  CA  . THR B 1 118 ? 20.53172  0.77450   -15.20831 1.000 50.24913  ? 211 THR B CA  1 
ATOM   2395 C  C   . THR B 1 118 ? 21.40710  0.21146   -16.31138 1.000 45.11859  ? 211 THR B C   1 
ATOM   2396 O  O   . THR B 1 118 ? 21.07753  0.39745   -17.48695 1.000 44.80540  ? 211 THR B O   1 
ATOM   2397 C  CB  . THR B 1 118 ? 20.69474  2.30324   -15.18626 1.000 47.68946  ? 211 THR B CB  1 
ATOM   2398 O  OG1 . THR B 1 118 ? 22.08607  2.65225   -15.12662 1.000 45.12401  ? 211 THR B OG1 1 
ATOM   2399 C  CG2 . THR B 1 118 ? 19.97923  2.88340   -13.99243 1.000 46.67734  ? 211 THR B CG2 1 
ATOM   2400 N  N   . PHE B 1 119 ? 22.51536  -0.44254  -15.95544 1.000 42.37853  ? 212 PHE B N   1 
ATOM   2401 C  CA  . PHE B 1 119 ? 23.53221  -0.93284  -16.88984 1.000 46.10178  ? 212 PHE B CA  1 
ATOM   2402 C  C   . PHE B 1 119 ? 24.23171  0.19746   -17.63188 1.000 41.17520  ? 212 PHE B C   1 
ATOM   2403 O  O   . PHE B 1 119 ? 24.90114  -0.04026  -18.63697 1.000 43.04851  ? 212 PHE B O   1 
ATOM   2404 C  CB  . PHE B 1 119 ? 22.95673  -1.94142  -17.89490 1.000 47.03945  ? 212 PHE B CB  1 
ATOM   2405 C  CG  . PHE B 1 119 ? 22.14828  -3.03463  -17.25722 1.000 55.32731  ? 212 PHE B CG  1 
ATOM   2406 C  CD1 . PHE B 1 119 ? 22.59060  -3.65268  -16.10503 1.000 53.72673  ? 212 PHE B CD1 1 
ATOM   2407 C  CD2 . PHE B 1 119 ? 20.94326  -3.43098  -17.80705 1.000 63.95039  ? 212 PHE B CD2 1 
ATOM   2408 C  CE1 . PHE B 1 119 ? 21.85294  -4.65807  -15.51154 1.000 68.32334  ? 212 PHE B CE1 1 
ATOM   2409 C  CE2 . PHE B 1 119 ? 20.19905  -4.43550  -17.21761 1.000 68.79797  ? 212 PHE B CE2 1 
ATOM   2410 C  CZ  . PHE B 1 119 ? 20.65514  -5.04956  -16.07029 1.000 67.03084  ? 212 PHE B CZ  1 
ATOM   2411 N  N   . ARG B 1 120 ? 24.11010  1.43254   -17.16159 1.000 40.40678  ? 213 ARG B N   1 
ATOM   2412 C  CA  . ARG B 1 120 ? 24.79886  2.52060   -17.82702 1.000 43.15620  ? 213 ARG B CA  1 
ATOM   2413 C  C   . ARG B 1 120 ? 26.25435  2.57715   -17.37999 1.000 38.03928  ? 213 ARG B C   1 
ATOM   2414 O  O   . ARG B 1 120 ? 26.59016  2.23798   -16.24236 1.000 38.86429  ? 213 ARG B O   1 
ATOM   2415 C  CB  . ARG B 1 120 ? 24.07898  3.83709   -17.54478 1.000 47.21760  ? 213 ARG B CB  1 
ATOM   2416 C  CG  . ARG B 1 120 ? 22.67421  3.79801   -18.09868 1.000 39.41997  ? 213 ARG B CG  1 
ATOM   2417 C  CD  . ARG B 1 120 ? 22.29904  5.08935   -18.74500 1.000 45.44622  ? 213 ARG B CD  1 
ATOM   2418 N  NE  . ARG B 1 120 ? 20.90901  5.11087   -19.17718 1.000 42.44427  ? 213 ARG B NE  1 
ATOM   2419 C  CZ  . ARG B 1 120 ? 20.52980  5.32221   -20.42812 1.000 47.54029  ? 213 ARG B CZ  1 
ATOM   2420 N  NH1 . ARG B 1 120 ? 21.41724  5.51001   -21.39339 1.000 41.11860  ? 213 ARG B NH1 1 
ATOM   2421 N  NH2 . ARG B 1 120 ? 19.22967  5.35494   -20.71622 1.000 45.89430  ? 213 ARG B NH2 1 
ATOM   2422 N  N   . HIS B 1 121 ? 27.12648  2.97558   -18.30290 1.000 33.21929  ? 214 HIS B N   1 
ATOM   2423 C  CA  . HIS B 1 121 ? 28.53481  3.15441   -17.98678 1.000 37.43304  ? 214 HIS B CA  1 
ATOM   2424 C  C   . HIS B 1 121 ? 28.80331  4.60363   -17.61738 1.000 36.44483  ? 214 HIS B C   1 
ATOM   2425 O  O   . HIS B 1 121 ? 28.12043  5.51613   -18.08073 1.000 32.60056  ? 214 HIS B O   1 
ATOM   2426 C  CB  . HIS B 1 121 ? 29.42359  2.77383   -19.16341 1.000 38.47225  ? 214 HIS B CB  1 
ATOM   2427 C  CG  . HIS B 1 121 ? 29.23549  1.36883   -19.64382 1.000 43.59263  ? 214 HIS B CG  1 
ATOM   2428 N  ND1 . HIS B 1 121 ? 29.66070  0.94662   -20.88725 1.000 39.59199  ? 214 HIS B ND1 1 
ATOM   2429 C  CD2 . HIS B 1 121 ? 28.68119  0.28831   -19.04761 1.000 45.21375  ? 214 HIS B CD2 1 
ATOM   2430 C  CE1 . HIS B 1 121 ? 29.36977  -0.33172  -21.03659 1.000 36.96897  ? 214 HIS B CE1 1 
ATOM   2431 N  NE2 . HIS B 1 121 ? 28.77797  -0.75513  -19.93436 1.000 41.56663  ? 214 HIS B NE2 1 
ATOM   2432 N  N   . SER B 1 122 ? 29.81944  4.81177   -16.79288 1.000 35.22799  ? 215 SER B N   1 
ATOM   2433 C  CA  . SER B 1 122 ? 30.26682  6.16224   -16.49909 1.000 36.74659  ? 215 SER B CA  1 
ATOM   2434 C  C   . SER B 1 122 ? 31.67365  6.07549   -15.94517 1.000 32.76024  ? 215 SER B C   1 
ATOM   2435 O  O   . SER B 1 122 ? 32.13767  4.99852   -15.55993 1.000 35.91920  ? 215 SER B O   1 
ATOM   2436 C  CB  . SER B 1 122 ? 29.33337  6.87468   -15.52492 1.000 32.86891  ? 215 SER B CB  1 
ATOM   2437 O  OG  . SER B 1 122 ? 29.32407  6.20784   -14.28077 1.000 35.40195  ? 215 SER B OG  1 
ATOM   2438 N  N   . VAL B 1 123 ? 32.36365  7.21392   -15.95212 1.000 33.13959  ? 216 VAL B N   1 
ATOM   2439 C  CA  . VAL B 1 123 ? 33.73245  7.29178   -15.45930 1.000 30.66485  ? 216 VAL B CA  1 
ATOM   2440 C  C   . VAL B 1 123 ? 33.82740  8.50724   -14.54922 1.000 38.86560  ? 216 VAL B C   1 
ATOM   2441 O  O   . VAL B 1 123 ? 33.38242  9.60345   -14.91600 1.000 37.80140  ? 216 VAL B O   1 
ATOM   2442 C  CB  . VAL B 1 123 ? 34.77175  7.36427   -16.59788 1.000 36.65265  ? 216 VAL B CB  1 
ATOM   2443 C  CG1 . VAL B 1 123 ? 34.43801  8.48549   -17.65409 1.000 29.92695  ? 216 VAL B CG1 1 
ATOM   2444 C  CG2 . VAL B 1 123 ? 36.16165  7.56202   -16.00072 1.000 33.51110  ? 216 VAL B CG2 1 
ATOM   2445 N  N   . VAL B 1 124 ? 34.38151  8.31276   -13.35545 1.000 35.57562  ? 217 VAL B N   1 
ATOM   2446 C  CA  . VAL B 1 124 ? 34.36113  9.33871   -12.32194 1.000 35.85693  ? 217 VAL B CA  1 
ATOM   2447 C  C   . VAL B 1 124 ? 35.76825  9.54909   -11.77117 1.000 37.18889  ? 217 VAL B C   1 
ATOM   2448 O  O   . VAL B 1 124 ? 36.54169  8.59468   -11.63160 1.000 40.66968  ? 217 VAL B O   1 
ATOM   2449 C  CB  . VAL B 1 124 ? 33.35093  8.97439   -11.21005 1.000 41.31607  ? 217 VAL B CB  1 
ATOM   2450 C  CG1 . VAL B 1 124 ? 33.68380  7.62402   -10.56929 1.000 45.97430  ? 217 VAL B CG1 1 
ATOM   2451 C  CG2 . VAL B 1 124 ? 33.23741  10.09505  -10.17591 1.000 35.23002  ? 217 VAL B CG2 1 
ATOM   2452 N  N   . VAL B 1 125 ? 36.11013  10.81081  -11.51195 1.000 36.37083  ? 218 VAL B N   1 
ATOM   2453 C  CA  . VAL B 1 125 ? 37.39770  11.22397  -10.94939 1.000 42.42656  ? 218 VAL B CA  1 
ATOM   2454 C  C   . VAL B 1 125 ? 37.14836  12.20135  -9.80479  1.000 38.48449  ? 218 VAL B C   1 
ATOM   2455 O  O   . VAL B 1 125 ? 36.10217  12.86987  -9.74041  1.000 42.03777  ? 218 VAL B O   1 
ATOM   2456 C  CB  . VAL B 1 125 ? 38.30611  11.88721  -12.01517 1.000 42.04595  ? 218 VAL B CB  1 
ATOM   2457 C  CG1 . VAL B 1 125 ? 38.48427  11.00593  -13.21811 1.000 40.68792  ? 218 VAL B CG1 1 
ATOM   2458 C  CG2 . VAL B 1 125 ? 37.74303  13.24147  -12.41627 1.000 37.42535  ? 218 VAL B CG2 1 
ATOM   2459 N  N   . PRO B 1 126 ? 38.10023  12.31943  -8.88320  1.000 40.09384  ? 219 PRO B N   1 
ATOM   2460 C  CA  . PRO B 1 126 ? 37.98718  13.34857  -7.84756  1.000 36.65703  ? 219 PRO B CA  1 
ATOM   2461 C  C   . PRO B 1 126 ? 38.07050  14.75095  -8.43535  1.000 39.11990  ? 219 PRO B C   1 
ATOM   2462 O  O   . PRO B 1 126 ? 38.87350  15.02336  -9.32639  1.000 42.54687  ? 219 PRO B O   1 
ATOM   2463 C  CB  . PRO B 1 126 ? 39.18380  13.05443  -6.93566  1.000 35.96861  ? 219 PRO B CB  1 
ATOM   2464 C  CG  . PRO B 1 126 ? 39.45867  11.61066  -7.14781  1.000 42.64981  ? 219 PRO B CG  1 
ATOM   2465 C  CD  . PRO B 1 126 ? 39.22486  11.40796  -8.61207  1.000 45.56251  ? 219 PRO B CD  1 
ATOM   2466 N  N   . CYS B 1 127 ? 37.23041  15.64623  -7.92873  1.000 37.61906  ? 220 CYS B N   1 
ATOM   2467 C  CA  . CYS B 1 127 ? 37.31645  17.04466  -8.31748  1.000 43.02311  ? 220 CYS B CA  1 
ATOM   2468 C  C   . CYS B 1 127 ? 38.53422  17.65419  -7.64794  1.000 44.31158  ? 220 CYS B C   1 
ATOM   2469 O  O   . CYS B 1 127 ? 38.64419  17.64752  -6.41995  1.000 49.37975  ? 220 CYS B O   1 
ATOM   2470 C  CB  . CYS B 1 127 ? 36.05689  17.80051  -7.91926  1.000 42.17624  ? 220 CYS B CB  1 
ATOM   2471 S  SG  . CYS B 1 127 ? 35.69352  19.23958  -8.96887  1.000 47.14411  ? 220 CYS B SG  1 
ATOM   2472 N  N   . GLU B 1 128 ? 39.44205  18.15932  -8.44222  1.000 41.89779  ? 221 GLU B N   1 
ATOM   2473 C  CA  . GLU B 1 128 ? 40.69152  18.74262  -8.00421  1.000 44.32000  ? 221 GLU B CA  1 
ATOM   2474 C  C   . GLU B 1 128 ? 40.68577  20.25066  -8.29565  1.000 55.98951  ? 221 GLU B C   1 
ATOM   2475 O  O   . GLU B 1 128 ? 40.00817  20.70169  -9.22834  1.000 49.49737  ? 221 GLU B O   1 
ATOM   2476 C  CB  . GLU B 1 128 ? 41.86898  18.06541  -8.72717  1.000 51.99258  ? 221 GLU B CB  1 
ATOM   2477 C  CG  . GLU B 1 128 ? 42.20623  16.64305  -8.24205  1.000 51.68642  ? 221 GLU B CG  1 
ATOM   2478 N  N   . PRO B 1 129 ? 41.39529  21.05744  -7.50645  1.000 49.45926  ? 222 PRO B N   1 
ATOM   2479 C  CA  . PRO B 1 129 ? 41.47756  22.50004  -7.78761  1.000 54.53729  ? 222 PRO B CA  1 
ATOM   2480 C  C   . PRO B 1 129 ? 42.39379  22.77151  -8.96522  1.000 43.44158  ? 222 PRO B C   1 
ATOM   2481 O  O   . PRO B 1 129 ? 43.16879  21.89270  -9.36151  1.000 42.01854  ? 222 PRO B O   1 
ATOM   2482 C  CB  . PRO B 1 129 ? 42.05530  23.08872  -6.48946  1.000 53.40572  ? 222 PRO B CB  1 
ATOM   2483 C  CG  . PRO B 1 129 ? 42.46201  21.92793  -5.63534  1.000 50.69987  ? 222 PRO B CG  1 
ATOM   2484 C  CD  . PRO B 1 129 ? 42.28613  20.66425  -6.40249  1.000 55.46119  ? 222 PRO B CD  1 
ATOM   2485 N  N   . PRO B 1 130 ? 42.32744  23.96025  -9.56590  1.000 48.51259  ? 223 PRO B N   1 
ATOM   2486 C  CA  . PRO B 1 130 ? 43.27195  24.28495  -10.64204 1.000 54.98239  ? 223 PRO B CA  1 
ATOM   2487 C  C   . PRO B 1 130 ? 44.71081  24.11196  -10.16991 1.000 62.48970  ? 223 PRO B C   1 
ATOM   2488 O  O   . PRO B 1 130 ? 45.05646  24.46369  -9.04099  1.000 65.62697  ? 223 PRO B O   1 
ATOM   2489 C  CB  . PRO B 1 130 ? 42.94954  25.74846  -10.96384 1.000 52.88559  ? 223 PRO B CB  1 
ATOM   2490 C  CG  . PRO B 1 130 ? 41.51116  25.89738  -10.59583 1.000 51.95797  ? 223 PRO B CG  1 
ATOM   2491 C  CD  . PRO B 1 130 ? 41.30618  25.01059  -9.39339  1.000 48.17234  ? 223 PRO B CD  1 
ATOM   2492 N  N   . GLU B 1 131 ? 45.53585  23.50553  -11.02162 1.000 65.87086  ? 224 GLU B N   1 
ATOM   2493 C  CA  . GLU B 1 131 ? 46.94737  23.34301  -10.70756 1.000 65.13309  ? 224 GLU B CA  1 
ATOM   2494 C  C   . GLU B 1 131 ? 47.63750  24.70545  -10.68932 1.000 69.66495  ? 224 GLU B C   1 
ATOM   2495 O  O   . GLU B 1 131 ? 47.13482  25.68658  -11.24500 1.000 71.67099  ? 224 GLU B O   1 
ATOM   2496 C  CB  . GLU B 1 131 ? 47.62148  22.41843  -11.72192 1.000 70.80643  ? 224 GLU B CB  1 
ATOM   2497 N  N   . VAL B 1 132 ? 48.80431  24.75695  -10.03459 1.000 70.84618  ? 225 VAL B N   1 
ATOM   2498 C  CA  . VAL B 1 132 ? 49.47013  26.03329  -9.78199  1.000 73.36555  ? 225 VAL B CA  1 
ATOM   2499 C  C   . VAL B 1 132 ? 49.84992  26.71017  -11.09364 1.000 71.56998  ? 225 VAL B C   1 
ATOM   2500 O  O   . VAL B 1 132 ? 50.30934  26.06589  -12.04722 1.000 76.35254  ? 225 VAL B O   1 
ATOM   2501 C  CB  . VAL B 1 132 ? 50.70363  25.83521  -8.88513  1.000 59.57303  ? 225 VAL B CB  1 
ATOM   2502 N  N   . GLY B 1 133 ? 49.63685  28.02281  -11.14798 1.000 71.77035  ? 226 GLY B N   1 
ATOM   2503 C  CA  . GLY B 1 133 ? 49.84096  28.77323  -12.36604 1.000 72.29146  ? 226 GLY B CA  1 
ATOM   2504 C  C   . GLY B 1 133 ? 48.69465  28.72240  -13.34858 1.000 83.02921  ? 226 GLY B C   1 
ATOM   2505 O  O   . GLY B 1 133 ? 48.84235  29.21670  -14.47235 1.000 89.13768  ? 226 GLY B O   1 
ATOM   2506 N  N   . SER B 1 134 ? 47.55590  28.14752  -12.96749 1.000 80.97321  ? 227 SER B N   1 
ATOM   2507 C  CA  . SER B 1 134 ? 46.42472  27.97482  -13.86773 1.000 69.64130  ? 227 SER B CA  1 
ATOM   2508 C  C   . SER B 1 134 ? 45.15052  28.38559  -13.14468 1.000 70.23744  ? 227 SER B C   1 
ATOM   2509 O  O   . SER B 1 134 ? 45.11613  28.46542  -11.91311 1.000 70.44552  ? 227 SER B O   1 
ATOM   2510 C  CB  . SER B 1 134 ? 46.32342  26.52495  -14.35539 1.000 72.80053  ? 227 SER B CB  1 
ATOM   2511 O  OG  . SER B 1 134 ? 47.33298  25.72265  -13.75774 1.000 77.32436  ? 227 SER B OG  1 
ATOM   2512 N  N   . ASP B 1 135 ? 44.09452  28.65704  -13.92279 1.000 57.55610  ? 228 ASP B N   1 
ATOM   2513 C  CA  . ASP B 1 135 ? 42.82729  29.11619  -13.35971 1.000 51.94652  ? 228 ASP B CA  1 
ATOM   2514 C  C   . ASP B 1 135 ? 41.64965  28.28585  -13.85416 1.000 66.96099  ? 228 ASP B C   1 
ATOM   2515 O  O   . ASP B 1 135 ? 40.52758  28.78779  -13.94786 1.000 69.88262  ? 228 ASP B O   1 
ATOM   2516 C  CB  . ASP B 1 135 ? 42.59587  30.59584  -13.66893 1.000 79.25087  ? 228 ASP B CB  1 
ATOM   2517 N  N   . CYS B 1 136 ? 41.88502  27.01242  -14.16381 1.000 58.93346  ? 229 CYS B N   1 
ATOM   2518 C  CA  . CYS B 1 136 ? 40.83061  26.13187  -14.64427 1.000 49.07989  ? 229 CYS B CA  1 
ATOM   2519 C  C   . CYS B 1 136 ? 41.27147  24.70304  -14.38728 1.000 50.85759  ? 229 CYS B C   1 
ATOM   2520 O  O   . CYS B 1 136 ? 42.41618  24.34581  -14.68141 1.000 52.04260  ? 229 CYS B O   1 
ATOM   2521 C  CB  . CYS B 1 136 ? 40.56234  26.33633  -16.14386 1.000 58.26408  ? 229 CYS B CB  1 
ATOM   2522 S  SG  . CYS B 1 136 ? 39.16715  27.41414  -16.58721 1.000 68.91752  ? 229 CYS B SG  1 
ATOM   2523 N  N   . THR B 1 137 ? 40.37552  23.89573  -13.83649 1.000 50.20348  ? 230 THR B N   1 
ATOM   2524 C  CA  . THR B 1 137 ? 40.60591  22.46148  -13.77577 1.000 48.08689  ? 230 THR B CA  1 
ATOM   2525 C  C   . THR B 1 137 ? 40.27846  21.84014  -15.13312 1.000 44.86429  ? 230 THR B C   1 
ATOM   2526 O  O   . THR B 1 137 ? 39.28977  22.20526  -15.77624 1.000 46.59662  ? 230 THR B O   1 
ATOM   2527 C  CB  . THR B 1 137 ? 39.74778  21.84370  -12.66566 1.000 51.08342  ? 230 THR B CB  1 
ATOM   2528 O  OG1 . THR B 1 137 ? 40.06132  22.46872  -11.41581 1.000 50.20039  ? 230 THR B OG1 1 
ATOM   2529 C  CG2 . THR B 1 137 ? 39.98707  20.35677  -12.54674 1.000 42.64876  ? 230 THR B CG2 1 
ATOM   2530 N  N   . THR B 1 138 ? 41.11453  20.90276  -15.57058 1.000 45.38895  ? 231 THR B N   1 
ATOM   2531 C  CA  . THR B 1 138 ? 40.95934  20.26961  -16.86957 1.000 42.42797  ? 231 THR B CA  1 
ATOM   2532 C  C   . THR B 1 138 ? 40.91353  18.75511  -16.71678 1.000 42.58421  ? 231 THR B C   1 
ATOM   2533 O  O   . THR B 1 138 ? 41.73100  18.16893  -15.99643 1.000 47.24360  ? 231 THR B O   1 
ATOM   2534 C  CB  . THR B 1 138 ? 42.09883  20.68041  -17.80796 1.000 38.25367  ? 231 THR B CB  1 
ATOM   2535 O  OG1 . THR B 1 138 ? 42.03675  22.10500  -18.02439 1.000 58.13284  ? 231 THR B OG1 1 
ATOM   2536 C  CG2 . THR B 1 138 ? 41.98242  19.97519  -19.14195 1.000 37.56670  ? 231 THR B CG2 1 
ATOM   2537 N  N   . ILE B 1 139 ? 39.95799  18.12255  -17.38986 1.000 39.70111  ? 232 ILE B N   1 
ATOM   2538 C  CA  . ILE B 1 139 ? 39.89645  16.67105  -17.49350 1.000 41.83302  ? 232 ILE B CA  1 
ATOM   2539 C  C   . ILE B 1 139 ? 40.10032  16.30284  -18.95392 1.000 42.14365  ? 232 ILE B C   1 
ATOM   2540 O  O   . ILE B 1 139 ? 39.56753  16.96937  -19.84475 1.000 46.26032  ? 232 ILE B O   1 
ATOM   2541 C  CB  . ILE B 1 139 ? 38.56275  16.11979  -16.95294 1.000 42.80503  ? 232 ILE B CB  1 
ATOM   2542 C  CG1 . ILE B 1 139 ? 38.47552  16.36867  -15.45368 1.000 40.79330  ? 232 ILE B CG1 1 
ATOM   2543 C  CG2 . ILE B 1 139 ? 38.45939  14.63919  -17.18135 1.000 33.58714  ? 232 ILE B CG2 1 
ATOM   2544 C  CD1 . ILE B 1 139 ? 37.16932  15.97024  -14.87923 1.000 46.90630  ? 232 ILE B CD1 1 
ATOM   2545 N  N   . HIS B 1 140 ? 40.90272  15.27711  -19.20224 1.000 39.29946  ? 233 HIS B N   1 
ATOM   2546 C  CA  . HIS B 1 140 ? 41.15332  14.79859  -20.55217 1.000 40.68571  ? 233 HIS B CA  1 
ATOM   2547 C  C   . HIS B 1 140 ? 40.33655  13.53510  -20.77400 1.000 43.24081  ? 233 HIS B C   1 
ATOM   2548 O  O   . HIS B 1 140 ? 40.53067  12.54421  -20.07005 1.000 42.70866  ? 233 HIS B O   1 
ATOM   2549 C  CB  . HIS B 1 140 ? 42.64419  14.53055  -20.75988 1.000 44.77468  ? 233 HIS B CB  1 
ATOM   2550 C  CG  . HIS B 1 140 ? 43.50421  15.74987  -20.60755 1.000 55.28776  ? 233 HIS B CG  1 
ATOM   2551 N  ND1 . HIS B 1 140 ? 44.13492  16.07552  -19.42531 1.000 55.05902  ? 233 HIS B ND1 1 
ATOM   2552 C  CD2 . HIS B 1 140 ? 43.81651  16.73538  -21.48298 1.000 51.77356  ? 233 HIS B CD2 1 
ATOM   2553 C  CE1 . HIS B 1 140 ? 44.81026  17.19941  -19.58481 1.000 53.34299  ? 233 HIS B CE1 1 
ATOM   2554 N  NE2 . HIS B 1 140 ? 44.63522  17.61862  -20.82472 1.000 50.06974  ? 233 HIS B NE2 1 
ATOM   2555 N  N   . TYR B 1 141 ? 39.41773  13.57189  -21.73235 1.000 39.17349  ? 234 TYR B N   1 
ATOM   2556 C  CA  . TYR B 1 141 ? 38.59253  12.42000  -22.06603 1.000 42.87666  ? 234 TYR B CA  1 
ATOM   2557 C  C   . TYR B 1 141 ? 39.03165  11.79929  -23.38819 1.000 41.72681  ? 234 TYR B C   1 
ATOM   2558 O  O   . TYR B 1 141 ? 39.55458  12.48788  -24.26383 1.000 42.65432  ? 234 TYR B O   1 
ATOM   2559 C  CB  . TYR B 1 141 ? 37.11542  12.81856  -22.15668 1.000 33.28348  ? 234 TYR B CB  1 
ATOM   2560 C  CG  . TYR B 1 141 ? 36.48197  13.19478  -20.83792 1.000 36.15491  ? 234 TYR B CG  1 
ATOM   2561 C  CD1 . TYR B 1 141 ? 36.22549  12.23188  -19.86581 1.000 35.88104  ? 234 TYR B CD1 1 
ATOM   2562 C  CD2 . TYR B 1 141 ? 36.13140  14.51898  -20.56147 1.000 38.13022  ? 234 TYR B CD2 1 
ATOM   2563 C  CE1 . TYR B 1 141 ? 35.62919  12.56509  -18.65853 1.000 32.59663  ? 234 TYR B CE1 1 
ATOM   2564 C  CE2 . TYR B 1 141 ? 35.53651  14.86754  -19.34974 1.000 38.86124  ? 234 TYR B CE2 1 
ATOM   2565 C  CZ  . TYR B 1 141 ? 35.28921  13.88559  -18.40616 1.000 42.61404  ? 234 TYR B CZ  1 
ATOM   2566 O  OH  . TYR B 1 141 ? 34.70496  14.21280  -17.20535 1.000 40.91554  ? 234 TYR B OH  1 
ATOM   2567 N  N   . ASN B 1 142 ? 38.81939  10.48806  -23.52844 1.000 37.67358  ? 235 ASN B N   1 
ATOM   2568 C  CA  . ASN B 1 142 ? 38.93762  9.78281   -24.80463 1.000 39.61263  ? 235 ASN B CA  1 
ATOM   2569 C  C   . ASN B 1 142 ? 37.60114  9.15361   -25.17501 1.000 40.70934  ? 235 ASN B C   1 
ATOM   2570 O  O   . ASN B 1 142 ? 36.87635  8.65628   -24.31019 1.000 41.11805  ? 235 ASN B O   1 
ATOM   2571 C  CB  . ASN B 1 142 ? 39.98241  8.63971   -24.77653 1.000 41.53901  ? 235 ASN B CB  1 
ATOM   2572 C  CG  . ASN B 1 142 ? 41.36300  9.11114   -24.41954 1.000 54.85156  ? 235 ASN B CG  1 
ATOM   2573 O  OD1 . ASN B 1 142 ? 41.70085  10.29260  -24.57217 1.000 53.26196  ? 235 ASN B OD1 1 
ATOM   2574 N  ND2 . ASN B 1 142 ? 42.18424  8.18708   -23.93425 1.000 42.90485  ? 235 ASN B ND2 1 
ATOM   2575 N  N   . TYR B 1 143 ? 37.29411  9.12756   -26.46781 1.000 35.30343  ? 236 TYR B N   1 
ATOM   2576 C  CA  . TYR B 1 143 ? 36.12590  8.41496   -26.95592 1.000 36.84004  ? 236 TYR B CA  1 
ATOM   2577 C  C   . TYR B 1 143 ? 36.58961  7.26773   -27.83750 1.000 43.24674  ? 236 TYR B C   1 
ATOM   2578 O  O   . TYR B 1 143 ? 37.36703  7.47343   -28.77636 1.000 47.24040  ? 236 TYR B O   1 
ATOM   2579 C  CB  . TYR B 1 143 ? 35.18917  9.33909   -27.71713 1.000 29.79579  ? 236 TYR B CB  1 
ATOM   2580 C  CG  . TYR B 1 143 ? 34.51985  10.40056  -26.85469 1.000 42.43274  ? 236 TYR B CG  1 
ATOM   2581 C  CD1 . TYR B 1 143 ? 35.12239  11.63762  -26.63620 1.000 36.60541  ? 236 TYR B CD1 1 
ATOM   2582 C  CD2 . TYR B 1 143 ? 33.27928  10.16138  -26.27157 1.000 41.07926  ? 236 TYR B CD2 1 
ATOM   2583 C  CE1 . TYR B 1 143 ? 34.49370  12.61650  -25.84714 1.000 42.52734  ? 236 TYR B CE1 1 
ATOM   2584 C  CE2 . TYR B 1 143 ? 32.65208  11.11019  -25.49373 1.000 35.01569  ? 236 TYR B CE2 1 
ATOM   2585 C  CZ  . TYR B 1 143 ? 33.25847  12.34169  -25.28660 1.000 46.38598  ? 236 TYR B CZ  1 
ATOM   2586 O  OH  . TYR B 1 143 ? 32.62561  13.27768  -24.51135 1.000 42.92196  ? 236 TYR B OH  1 
ATOM   2587 N  N   . MET B 1 144 ? 36.10244  6.06268   -27.54298 1.000 46.73888  ? 237 MET B N   1 
ATOM   2588 C  CA  . MET B 1 144 ? 36.75499  4.84286   -28.00509 1.000 35.75090  ? 237 MET B CA  1 
ATOM   2589 C  C   . MET B 1 144 ? 35.96508  4.08112   -29.06228 1.000 36.08429  ? 237 MET B C   1 
ATOM   2590 O  O   . MET B 1 144 ? 36.30776  2.93326   -29.38157 1.000 42.65063  ? 237 MET B O   1 
ATOM   2591 C  CB  . MET B 1 144 ? 37.07242  3.96549   -26.79643 1.000 37.85699  ? 237 MET B CB  1 
ATOM   2592 C  CG  . MET B 1 144 ? 37.80706  4.79767   -25.75189 1.000 38.91863  ? 237 MET B CG  1 
ATOM   2593 S  SD  . MET B 1 144 ? 39.51562  5.06873   -26.24445 1.000 40.53729  ? 237 MET B SD  1 
ATOM   2594 C  CE  . MET B 1 144 ? 39.89686  3.35755   -26.80908 1.000 49.97398  ? 237 MET B CE  1 
ATOM   2595 N  N   . CYS B 1 145 ? 34.95292  4.70425   -29.64562 1.000 35.66640  ? 238 CYS B N   1 
ATOM   2596 C  CA  . CYS B 1 145 ? 34.19147  4.15349   -30.75522 1.000 40.69241  ? 238 CYS B CA  1 
ATOM   2597 C  C   . CYS B 1 145 ? 33.83229  5.29804   -31.68162 1.000 46.55693  ? 238 CYS B C   1 
ATOM   2598 O  O   . CYS B 1 145 ? 33.63168  6.42665   -31.23039 1.000 46.46783  ? 238 CYS B O   1 
ATOM   2599 C  CB  . CYS B 1 145 ? 32.90553  3.46524   -30.29081 1.000 44.57937  ? 238 CYS B CB  1 
ATOM   2600 S  SG  . CYS B 1 145 ? 32.79602  1.74040   -30.65697 1.000 47.25163  ? 238 CYS B SG  1 
ATOM   2601 N  N   . TYR B 1 146 ? 33.76697  5.00351   -32.97575 1.000 44.86698  ? 239 TYR B N   1 
ATOM   2602 C  CA  . TYR B 1 146 ? 33.28646  5.97771   -33.94333 1.000 45.33762  ? 239 TYR B CA  1 
ATOM   2603 C  C   . TYR B 1 146 ? 31.77520  6.11678   -33.83905 1.000 41.36366  ? 239 TYR B C   1 
ATOM   2604 O  O   . TYR B 1 146 ? 31.06973  5.16129   -33.50928 1.000 42.93110  ? 239 TYR B O   1 
ATOM   2605 C  CB  . TYR B 1 146 ? 33.64893  5.54724   -35.35712 1.000 50.19863  ? 239 TYR B CB  1 
ATOM   2606 C  CG  . TYR B 1 146 ? 35.08202  5.77487   -35.73416 1.000 54.02560  ? 239 TYR B CG  1 
ATOM   2607 C  CD1 . TYR B 1 146 ? 35.62292  7.05582   -35.74211 1.000 51.67168  ? 239 TYR B CD1 1 
ATOM   2608 C  CD2 . TYR B 1 146 ? 35.88988  4.71665   -36.10536 1.000 47.82644  ? 239 TYR B CD2 1 
ATOM   2609 C  CE1 . TYR B 1 146 ? 36.92737  7.26503   -36.09387 1.000 54.43666  ? 239 TYR B CE1 1 
ATOM   2610 C  CE2 . TYR B 1 146 ? 37.19988  4.91915   -36.45911 1.000 55.53602  ? 239 TYR B CE2 1 
ATOM   2611 C  CZ  . TYR B 1 146 ? 37.71344  6.19612   -36.45396 1.000 48.71152  ? 239 TYR B CZ  1 
ATOM   2612 O  OH  . TYR B 1 146 ? 39.02136  6.40959   -36.80855 1.000 52.04614  ? 239 TYR B OH  1 
ATOM   2613 N  N   . SER B 1 147 ? 31.27517  7.31847   -34.13331 1.000 40.42040  ? 240 SER B N   1 
ATOM   2614 C  CA  . SER B 1 147 ? 29.83160  7.51881   -34.17994 1.000 39.18442  ? 240 SER B CA  1 
ATOM   2615 C  C   . SER B 1 147 ? 29.16802  6.65682   -35.24262 1.000 46.24363  ? 240 SER B C   1 
ATOM   2616 O  O   . SER B 1 147 ? 27.98796  6.32009   -35.10073 1.000 47.67385  ? 240 SER B O   1 
ATOM   2617 C  CB  . SER B 1 147 ? 29.50289  8.99204   -34.42903 1.000 37.21893  ? 240 SER B CB  1 
ATOM   2618 O  OG  . SER B 1 147 ? 29.80566  9.78127   -33.28540 1.000 45.47659  ? 240 SER B OG  1 
ATOM   2619 N  N   . SER B 1 148 ? 29.90657  6.26795   -36.28076 1.000 48.10782  ? 241 SER B N   1 
ATOM   2620 C  CA  . SER B 1 148 ? 29.38397  5.46050   -37.37833 1.000 44.00076  ? 241 SER B CA  1 
ATOM   2621 C  C   . SER B 1 148 ? 29.40483  3.95639   -37.10768 1.000 46.86062  ? 241 SER B C   1 
ATOM   2622 O  O   . SER B 1 148 ? 28.87873  3.19411   -37.92410 1.000 46.77222  ? 241 SER B O   1 
ATOM   2623 C  CB  . SER B 1 148 ? 30.18294  5.74257   -38.65417 1.000 39.55776  ? 241 SER B CB  1 
ATOM   2624 O  OG  . SER B 1 148 ? 31.56817  5.49859   -38.44917 1.000 45.17382  ? 241 SER B OG  1 
ATOM   2625 N  N   . CYS B 1 149 ? 29.99072  3.50841   -35.99773 1.000 51.58828  ? 242 CYS B N   1 
ATOM   2626 C  CA  . CYS B 1 149 ? 30.16658  2.08150   -35.73710 1.000 43.91956  ? 242 CYS B CA  1 
ATOM   2627 C  C   . CYS B 1 149 ? 28.85238  1.31635   -35.67253 1.000 50.71356  ? 242 CYS B C   1 
ATOM   2628 O  O   . CYS B 1 149 ? 28.04719  1.53890   -34.76320 1.000 49.65335  ? 242 CYS B O   1 
ATOM   2629 C  CB  . CYS B 1 149 ? 30.91922  1.87112   -34.42622 1.000 40.82689  ? 242 CYS B CB  1 
ATOM   2630 S  SG  . CYS B 1 149 ? 32.69869  1.99446   -34.56574 1.000 44.62786  ? 242 CYS B SG  1 
ATOM   2631 N  N   . MET B 1 150 ? 28.62866  0.41132   -36.62526 1.000 49.92887  ? 243 MET B N   1 
ATOM   2632 C  CA  . MET B 1 150 ? 27.49003  -0.49184  -36.53476 1.000 44.28272  ? 243 MET B CA  1 
ATOM   2633 C  C   . MET B 1 150 ? 27.67173  -1.41672  -35.34058 1.000 47.63573  ? 243 MET B C   1 
ATOM   2634 O  O   . MET B 1 150 ? 28.79250  -1.78511  -34.97293 1.000 49.02845  ? 243 MET B O   1 
ATOM   2635 C  CB  . MET B 1 150 ? 27.34065  -1.30703  -37.82352 1.000 54.93677  ? 243 MET B CB  1 
ATOM   2636 C  CG  . MET B 1 150 ? 27.79247  -0.55856  -39.07791 1.000 56.92749  ? 243 MET B CG  1 
ATOM   2637 S  SD  . MET B 1 150 ? 26.89956  -1.02043  -40.57993 1.000 88.72440  ? 243 MET B SD  1 
ATOM   2638 C  CE  . MET B 1 150 ? 28.06900  -0.48885  -41.83557 1.000 45.79510  ? 243 MET B CE  1 
ATOM   2639 N  N   . GLY B 1 151 ? 26.55877  -1.77993  -34.71851 1.000 47.28825  ? 244 GLY B N   1 
ATOM   2640 C  CA  . GLY B 1 151 ? 26.62259  -2.51313  -33.47534 1.000 43.25028  ? 244 GLY B CA  1 
ATOM   2641 C  C   . GLY B 1 151 ? 26.87486  -1.64327  -32.26920 1.000 44.83390  ? 244 GLY B C   1 
ATOM   2642 O  O   . GLY B 1 151 ? 26.86005  -2.14979  -31.14467 1.000 48.10771  ? 244 GLY B O   1 
ATOM   2643 N  N   . GLY B 1 152 ? 27.12733  -0.35337  -32.46379 1.000 47.26278  ? 245 GLY B N   1 
ATOM   2644 C  CA  . GLY B 1 152 ? 27.21132  0.59130   -31.36685 1.000 38.76182  ? 245 GLY B CA  1 
ATOM   2645 C  C   . GLY B 1 152 ? 26.34363  1.80185   -31.64123 1.000 47.03593  ? 245 GLY B C   1 
ATOM   2646 O  O   . GLY B 1 152 ? 25.13073  1.67247   -31.82832 1.000 41.71920  ? 245 GLY B O   1 
ATOM   2647 N  N   . MET B 1 153 ? 26.96689  2.98388   -31.68497 1.000 42.55518  ? 246 MET B N   1 
ATOM   2648 C  CA  . MET B 1 153 ? 26.20925  4.21657   -31.86345 1.000 44.00176  ? 246 MET B CA  1 
ATOM   2649 C  C   . MET B 1 153 ? 25.49761  4.25747   -33.20631 1.000 45.06603  ? 246 MET B C   1 
ATOM   2650 O  O   . MET B 1 153 ? 24.40730  4.83527   -33.30154 1.000 39.66005  ? 246 MET B O   1 
ATOM   2651 C  CB  . MET B 1 153 ? 27.12548  5.42262   -31.66272 1.000 36.93274  ? 246 MET B CB  1 
ATOM   2652 C  CG  . MET B 1 153 ? 27.71591  5.49064   -30.23598 1.000 35.30238  ? 246 MET B CG  1 
ATOM   2653 S  SD  . MET B 1 153 ? 28.77880  6.92211   -29.91434 1.000 43.85047  ? 246 MET B SD  1 
ATOM   2654 C  CE  . MET B 1 153 ? 30.31540  6.38719   -30.67901 1.000 46.73126  ? 246 MET B CE  1 
ATOM   2655 N  N   . ASN B 1 154 ? 26.07294  3.62173   -34.23010 1.000 49.35545  ? 247 ASN B N   1 
ATOM   2656 C  CA  . ASN B 1 154 ? 25.39478  3.35337   -35.50682 1.000 46.63257  ? 247 ASN B CA  1 
ATOM   2657 C  C   . ASN B 1 154 ? 24.81045  4.62715   -36.11640 1.000 42.73480  ? 247 ASN B C   1 
ATOM   2658 O  O   . ASN B 1 154 ? 23.63763  4.68697   -36.49349 1.000 48.56673  ? 247 ASN B O   1 
ATOM   2659 C  CB  . ASN B 1 154 ? 24.31852  2.28006   -35.33560 1.000 45.47496  ? 247 ASN B CB  1 
ATOM   2660 C  CG  . ASN B 1 154 ? 23.84270  1.70607   -36.66371 1.000 51.48572  ? 247 ASN B CG  1 
ATOM   2661 O  OD1 . ASN B 1 154 ? 24.56086  1.73677   -37.66987 1.000 52.47515  ? 247 ASN B OD1 1 
ATOM   2662 N  ND2 . ASN B 1 154 ? 22.61259  1.20582   -36.67559 1.000 49.12386  ? 247 ASN B ND2 1 
ATOM   2663 N  N   . ARG B 1 155 ? 25.64728  5.66535   -36.16616 1.000 44.52855  ? 248 ARG B N   1 
ATOM   2664 C  CA  . ARG B 1 155 ? 25.34479  7.00474   -36.66901 1.000 46.15386  ? 248 ARG B CA  1 
ATOM   2665 C  C   . ARG B 1 155 ? 24.35674  7.76877   -35.78443 1.000 55.74010  ? 248 ARG B C   1 
ATOM   2666 O  O   . ARG B 1 155 ? 23.89467  8.84434   -36.18053 1.000 52.30459  ? 248 ARG B O   1 
ATOM   2667 C  CB  . ARG B 1 155 ? 24.85715  6.96375   -38.13124 1.000 52.22589  ? 248 ARG B CB  1 
ATOM   2668 C  CG  . ARG B 1 155 ? 25.79861  6.17148   -39.06936 1.000 52.03320  ? 248 ARG B CG  1 
ATOM   2669 C  CD  . ARG B 1 155 ? 25.19435  5.89533   -40.45391 1.000 47.87937  ? 248 ARG B CD  1 
ATOM   2670 N  N   . ARG B 1 156 ? 24.04522  7.27335   -34.54838 1.000 40.82314  ? 249 ARG B N   1 
ATOM   2671 C  CA  . ARG B 1 156 ? 23.10987  8.08417   -33.75546 1.000 46.43098  ? 249 ARG B CA  1 
ATOM   2672 C  C   . ARG B 1 156 ? 23.87044  9.10446   -32.90417 1.000 44.98317  ? 249 ARG B C   1 
ATOM   2673 O  O   . ARG B 1 156 ? 24.85697  8.73757   -32.25080 1.000 41.58904  ? 249 ARG B O   1 
ATOM   2674 C  CB  . ARG B 1 156 ? 22.26327  7.19338   -32.86029 1.000 45.62483  ? 249 ARG B CB  1 
ATOM   2675 C  CG  . ARG B 1 156 ? 21.47072  6.13628   -33.64240 1.000 38.60517  ? 249 ARG B CG  1 
ATOM   2676 C  CD  . ARG B 1 156 ? 20.94283  5.06650   -32.73076 1.000 34.05080  ? 249 ARG B CD  1 
ATOM   2677 N  NE  . ARG B 1 156 ? 21.98713  4.16719   -32.24757 1.000 39.81466  ? 249 ARG B NE  1 
ATOM   2678 C  CZ  . ARG B 1 156 ? 21.76332  3.13403   -31.44819 1.000 42.85091  ? 249 ARG B CZ  1 
ATOM   2679 N  NH1 . ARG B 1 156 ? 20.54739  2.86062   -31.00057 1.000 42.82254  ? 249 ARG B NH1 1 
ATOM   2680 N  NH2 . ARG B 1 156 ? 22.78334  2.35649   -31.08760 1.000 45.01053  ? 249 ARG B NH2 1 
ATOM   2681 N  N   . PRO B 1 157 ? 23.47173  10.38101  -32.88565 1.000 40.40079  ? 250 PRO B N   1 
ATOM   2682 C  CA  . PRO B 1 157 ? 24.18711  11.35524  -32.04470 1.000 44.64931  ? 250 PRO B CA  1 
ATOM   2683 C  C   . PRO B 1 157 ? 24.08031  11.00649  -30.56400 1.000 45.05904  ? 250 PRO B C   1 
ATOM   2684 O  O   . PRO B 1 157 ? 23.07140  10.46553  -30.10292 1.000 43.55686  ? 250 PRO B O   1 
ATOM   2685 C  CB  . PRO B 1 157 ? 23.49369  12.69091  -32.36661 1.000 41.77915  ? 250 PRO B CB  1 
ATOM   2686 C  CG  . PRO B 1 157 ? 22.15438  12.31979  -32.85458 1.000 52.08761  ? 250 PRO B CG  1 
ATOM   2687 C  CD  . PRO B 1 157 ? 22.33015  11.00186  -33.58472 1.000 45.38555  ? 250 PRO B CD  1 
ATOM   2688 N  N   . ILE B 1 158 ? 25.15322  11.28712  -29.82602 1.000 39.05390  ? 251 ILE B N   1 
ATOM   2689 C  CA  . ILE B 1 158 ? 25.15829  11.10401  -28.38252 1.000 34.24668  ? 251 ILE B CA  1 
ATOM   2690 C  C   . ILE B 1 158 ? 25.42084  12.43375  -27.68795 1.000 43.24073  ? 251 ILE B C   1 
ATOM   2691 O  O   . ILE B 1 158 ? 26.01668  13.36684  -28.24723 1.000 39.70728  ? 251 ILE B O   1 
ATOM   2692 C  CB  . ILE B 1 158 ? 26.19279  10.07122  -27.90115 1.000 39.61167  ? 251 ILE B CB  1 
ATOM   2693 C  CG1 . ILE B 1 158 ? 27.59953  10.54807  -28.24800 1.000 38.23290  ? 251 ILE B CG1 1 
ATOM   2694 C  CG2 . ILE B 1 158 ? 25.91870  8.66367   -28.48144 1.000 32.19905  ? 251 ILE B CG2 1 
ATOM   2695 C  CD1 . ILE B 1 158 ? 28.67966  9.96666   -27.32753 1.000 41.26512  ? 251 ILE B CD1 1 
ATOM   2696 N  N   A LEU B 1 159 ? 24.94210  12.51702  -26.45133 0.500 35.88654  ? 252 LEU B N   1 
ATOM   2697 N  N   B LEU B 1 159 ? 24.98753  12.49217  -26.43765 0.500 35.88962  ? 252 LEU B N   1 
ATOM   2698 C  CA  A LEU B 1 159 ? 25.27793  13.58323  -25.52538 0.500 37.75050  ? 252 LEU B CA  1 
ATOM   2699 C  CA  B LEU B 1 159 ? 25.26705  13.58867  -25.53103 0.500 37.75296  ? 252 LEU B CA  1 
ATOM   2700 C  C   A LEU B 1 159 ? 26.18816  13.02983  -24.44384 0.500 38.70753  ? 252 LEU B C   1 
ATOM   2701 C  C   B LEU B 1 159 ? 26.14638  13.06390  -24.40719 0.500 38.72203  ? 252 LEU B C   1 
ATOM   2702 O  O   A LEU B 1 159 ? 25.97583  11.91861  -23.95291 0.500 35.47475  ? 252 LEU B O   1 
ATOM   2703 O  O   B LEU B 1 159 ? 25.88145  11.98796  -23.86317 0.500 35.45200  ? 252 LEU B O   1 
ATOM   2704 C  CB  A LEU B 1 159 ? 24.02422  14.17607  -24.87382 0.500 38.77841  ? 252 LEU B CB  1 
ATOM   2705 C  CB  B LEU B 1 159 ? 23.95740  14.15675  -24.97898 0.500 38.81502  ? 252 LEU B CB  1 
ATOM   2706 C  CG  A LEU B 1 159 ? 22.91561  14.59126  -25.83570 0.500 42.01848  ? 252 LEU B CG  1 
ATOM   2707 C  CG  B LEU B 1 159 ? 23.93288  15.32749  -24.00759 0.500 42.11753  ? 252 LEU B CG  1 
ATOM   2708 C  CD1 A LEU B 1 159 ? 21.64978  14.98820  -25.09139 0.500 36.06175  ? 252 LEU B CD1 1 
ATOM   2709 C  CD1 B LEU B 1 159 ? 24.03652  16.64528  -24.76213 0.500 41.08393  ? 252 LEU B CD1 1 
ATOM   2710 C  CD2 A LEU B 1 159 ? 23.41939  15.71602  -26.70789 0.500 40.87631  ? 252 LEU B CD2 1 
ATOM   2711 C  CD2 B LEU B 1 159 ? 22.64306  15.26901  -23.21648 0.500 39.07206  ? 252 LEU B CD2 1 
ATOM   2712 N  N   . THR B 1 160 ? 27.19486  13.80708  -24.07378 1.000 37.14448  ? 253 THR B N   1 
ATOM   2713 C  CA  . THR B 1 160 ? 27.99511  13.53323  -22.89092 1.000 36.33556  ? 253 THR B CA  1 
ATOM   2714 C  C   . THR B 1 160 ? 27.47683  14.40906  -21.76055 1.000 34.32792  ? 253 THR B C   1 
ATOM   2715 O  O   . THR B 1 160 ? 27.37205  15.62483  -21.91975 1.000 36.55821  ? 253 THR B O   1 
ATOM   2716 C  CB  . THR B 1 160 ? 29.47404  13.81111  -23.14561 1.000 37.64210  ? 253 THR B CB  1 
ATOM   2717 O  OG1 . THR B 1 160 ? 29.97226  12.84990  -24.08521 1.000 38.19891  ? 253 THR B OG1 1 
ATOM   2718 C  CG2 . THR B 1 160 ? 30.25352  13.70547  -21.85183 1.000 37.79237  ? 253 THR B CG2 1 
ATOM   2719 N  N   . ILE B 1 161 ? 27.12384  13.78994  -20.63853 1.000 39.27953  ? 254 ILE B N   1 
ATOM   2720 C  CA  . ILE B 1 161 ? 26.64960  14.49795  -19.45358 1.000 41.72674  ? 254 ILE B CA  1 
ATOM   2721 C  C   . ILE B 1 161 ? 27.75424  14.45170  -18.41095 1.000 40.85627  ? 254 ILE B C   1 
ATOM   2722 O  O   . ILE B 1 161 ? 28.21243  13.36550  -18.03664 1.000 35.94304  ? 254 ILE B O   1 
ATOM   2723 C  CB  . ILE B 1 161 ? 25.36477  13.88227  -18.88323 1.000 40.40843  ? 254 ILE B CB  1 
ATOM   2724 C  CG1 . ILE B 1 161 ? 24.23896  13.87642  -19.91585 1.000 46.07301  ? 254 ILE B CG1 1 
ATOM   2725 C  CG2 . ILE B 1 161 ? 24.93964  14.60669  -17.59989 1.000 31.11400  ? 254 ILE B CG2 1 
ATOM   2726 C  CD1 . ILE B 1 161 ? 23.16070  12.84538  -19.56569 1.000 43.41963  ? 254 ILE B CD1 1 
ATOM   2727 N  N   . ILE B 1 162 ? 28.16580  15.62650  -17.93961 1.000 33.37456  ? 255 ILE B N   1 
ATOM   2728 C  CA  . ILE B 1 162 ? 29.16051  15.77760  -16.88770 1.000 33.51643  ? 255 ILE B CA  1 
ATOM   2729 C  C   . ILE B 1 162 ? 28.44751  16.23556  -15.62704 1.000 39.77538  ? 255 ILE B C   1 
ATOM   2730 O  O   . ILE B 1 162 ? 27.85493  17.32352  -15.60528 1.000 41.90540  ? 255 ILE B O   1 
ATOM   2731 C  CB  . ILE B 1 162 ? 30.23261  16.80258  -17.27495 1.000 33.73249  ? 255 ILE B CB  1 
ATOM   2732 C  CG1 . ILE B 1 162 ? 30.80506  16.47069  -18.63353 1.000 32.58263  ? 255 ILE B CG1 1 
ATOM   2733 C  CG2 . ILE B 1 162 ? 31.31889  16.83778  -16.22799 1.000 42.97864  ? 255 ILE B CG2 1 
ATOM   2734 C  CD1 . ILE B 1 162 ? 31.55877  15.21102  -18.63654 1.000 39.58510  ? 255 ILE B CD1 1 
ATOM   2735 N  N   . THR B 1 163 ? 28.53049  15.44249  -14.56756 1.000 37.29600  ? 256 THR B N   1 
ATOM   2736 C  CA  . THR B 1 163 ? 27.88983  15.80111  -13.31504 1.000 35.18148  ? 256 THR B CA  1 
ATOM   2737 C  C   . THR B 1 163 ? 28.93318  16.00725  -12.23161 1.000 41.07439  ? 256 THR B C   1 
ATOM   2738 O  O   . THR B 1 163 ? 29.92027  15.26636  -12.14945 1.000 39.64095  ? 256 THR B O   1 
ATOM   2739 C  CB  . THR B 1 163 ? 26.87162  14.75839  -12.87953 1.000 35.41222  ? 256 THR B CB  1 
ATOM   2740 O  OG1 . THR B 1 163 ? 27.46111  13.44929  -12.92897 1.000 50.64216  ? 256 THR B OG1 1 
ATOM   2741 C  CG2 . THR B 1 163 ? 25.67842  14.78713  -13.80699 1.000 42.85109  ? 256 THR B CG2 1 
ATOM   2742 N  N   . LEU B 1 164 ? 28.71469  17.04960  -11.43340 1.000 40.04818  ? 257 LEU B N   1 
ATOM   2743 C  CA  . LEU B 1 164 ? 29.43919  17.26577  -10.18861 1.000 36.58107  ? 257 LEU B CA  1 
ATOM   2744 C  C   . LEU B 1 164 ? 28.63960  16.64832  -9.05130  1.000 40.72497  ? 257 LEU B C   1 
ATOM   2745 O  O   . LEU B 1 164 ? 27.43248  16.90082  -8.92486  1.000 38.90243  ? 257 LEU B O   1 
ATOM   2746 C  CB  . LEU B 1 164 ? 29.64088  18.76445  -9.96114  1.000 39.62126  ? 257 LEU B CB  1 
ATOM   2747 C  CG  . LEU B 1 164 ? 30.61926  19.23671  -8.88922  1.000 41.92874  ? 257 LEU B CG  1 
ATOM   2748 C  CD1 . LEU B 1 164 ? 32.04288  19.11386  -9.38698  1.000 42.10045  ? 257 LEU B CD1 1 
ATOM   2749 C  CD2 . LEU B 1 164 ? 30.31510  20.68213  -8.52483  1.000 40.23016  ? 257 LEU B CD2 1 
ATOM   2750 N  N   . GLU B 1 165 ? 29.29863  15.81177  -8.24440  1.000 36.51173  ? 258 GLU B N   1 
ATOM   2751 C  CA  . GLU B 1 165 ? 28.61854  15.05946  -7.19790  1.000 40.63499  ? 258 GLU B CA  1 
ATOM   2752 C  C   . GLU B 1 165 ? 29.37780  15.11816  -5.88638  1.000 40.28629  ? 258 GLU B C   1 
ATOM   2753 O  O   . GLU B 1 165 ? 30.61381  15.18383  -5.86139  1.000 40.27716  ? 258 GLU B O   1 
ATOM   2754 C  CB  . GLU B 1 165 ? 28.45036  13.55730  -7.54821  1.000 36.46282  ? 258 GLU B CB  1 
ATOM   2755 C  CG  . GLU B 1 165 ? 28.50112  13.23098  -9.00572  1.000 41.40371  ? 258 GLU B CG  1 
ATOM   2756 C  CD  . GLU B 1 165 ? 28.45270  11.73267  -9.26352  1.000 53.05071  ? 258 GLU B CD  1 
ATOM   2757 O  OE1 . GLU B 1 165 ? 29.17018  10.97203  -8.56500  1.000 42.04690  ? 258 GLU B OE1 1 
ATOM   2758 O  OE2 . GLU B 1 165 ? 27.69909  11.31980  -10.17557 1.000 52.84343  ? 258 GLU B OE2 1 
ATOM   2759 N  N   . ASP B 1 166 ? 28.63019  15.00102  -4.79394  1.000 38.31662  ? 259 ASP B N   1 
ATOM   2760 C  CA  . ASP B 1 166 ? 29.26199  14.89057  -3.49178  1.000 39.32507  ? 259 ASP B CA  1 
ATOM   2761 C  C   . ASP B 1 166 ? 29.78730  13.47327  -3.29106  1.000 38.63440  ? 259 ASP B C   1 
ATOM   2762 O  O   . ASP B 1 166 ? 29.69753  12.62096  -4.17192  1.000 39.07971  ? 259 ASP B O   1 
ATOM   2763 C  CB  . ASP B 1 166 ? 28.30435  15.33503  -2.38134  1.000 40.68445  ? 259 ASP B CB  1 
ATOM   2764 C  CG  . ASP B 1 166 ? 27.10112  14.41236  -2.19031  1.000 47.16322  ? 259 ASP B CG  1 
ATOM   2765 O  OD1 . ASP B 1 166 ? 26.16458  14.85898  -1.49353  1.000 46.33298  ? 259 ASP B OD1 1 
ATOM   2766 O  OD2 . ASP B 1 166 ? 27.06271  13.26413  -2.68996  1.000 42.32135  ? 259 ASP B OD2 1 
ATOM   2767 N  N   . SER B 1 167 ? 30.32048  13.21596  -2.09967  1.000 40.61546  ? 260 SER B N   1 
ATOM   2768 C  CA  . SER B 1 167 ? 30.99888  11.95326  -1.84311  1.000 39.42363  ? 260 SER B CA  1 
ATOM   2769 C  C   . SER B 1 167 ? 30.03591  10.76841  -1.88262  1.000 39.10633  ? 260 SER B C   1 
ATOM   2770 O  O   . SER B 1 167 ? 30.45762  9.64804   -2.16487  1.000 36.24747  ? 260 SER B O   1 
ATOM   2771 C  CB  . SER B 1 167 ? 31.70318  12.01918  -0.49249  1.000 39.05787  ? 260 SER B CB  1 
ATOM   2772 O  OG  . SER B 1 167 ? 30.78081  12.42746  0.49910   1.000 43.21413  ? 260 SER B OG  1 
ATOM   2773 N  N   . SER B 1 168 ? 28.75415  11.00925  -1.60259  1.000 39.88622  ? 261 SER B N   1 
ATOM   2774 C  CA  . SER B 1 168 ? 27.69017  10.02570  -1.69241  1.000 42.24144  ? 261 SER B CA  1 
ATOM   2775 C  C   . SER B 1 168 ? 27.19991  9.80227   -3.11368  1.000 48.40403  ? 261 SER B C   1 
ATOM   2776 O  O   . SER B 1 168 ? 26.50347  8.81292   -3.36619  1.000 49.90414  ? 261 SER B O   1 
ATOM   2777 C  CB  . SER B 1 168 ? 26.49537  10.47329  -0.84600  1.000 43.09563  ? 261 SER B CB  1 
ATOM   2778 O  OG  . SER B 1 168 ? 26.76798  10.37483  0.53637   1.000 51.35208  ? 261 SER B OG  1 
ATOM   2779 N  N   . GLY B 1 169 ? 27.52099  10.69831  -4.03550  1.000 44.84048  ? 262 GLY B N   1 
ATOM   2780 C  CA  . GLY B 1 169 ? 26.95088  10.65096  -5.36465  1.000 40.98651  ? 262 GLY B CA  1 
ATOM   2781 C  C   . GLY B 1 169 ? 25.72388  11.50842  -5.57672  1.000 41.39403  ? 262 GLY B C   1 
ATOM   2782 O  O   . GLY B 1 169 ? 25.10729  11.41067  -6.64005  1.000 41.10296  ? 262 GLY B O   1 
ATOM   2783 N  N   . ASN B 1 170 ? 25.34362  12.34314  -4.60875  1.000 42.21255  ? 263 ASN B N   1 
ATOM   2784 C  CA  . ASN B 1 170 ? 24.25181  13.28364  -4.82789  1.000 48.47522  ? 263 ASN B CA  1 
ATOM   2785 C  C   . ASN B 1 170 ? 24.66853  14.36822  -5.82529  1.000 44.38024  ? 263 ASN B C   1 
ATOM   2786 O  O   . ASN B 1 170 ? 25.84156  14.70667  -5.94875  1.000 43.59204  ? 263 ASN B O   1 
ATOM   2787 C  CB  . ASN B 1 170 ? 23.82600  13.94466  -3.51275  1.000 45.96825  ? 263 ASN B CB  1 
ATOM   2788 C  CG  . ASN B 1 170 ? 23.48091  12.94192  -2.41481  1.000 47.47485  ? 263 ASN B CG  1 
ATOM   2789 O  OD1 . ASN B 1 170 ? 22.62276  12.08430  -2.58545  1.000 47.12924  ? 263 ASN B OD1 1 
ATOM   2790 N  ND2 . ASN B 1 170 ? 24.14187  13.07333  -1.26909  1.000 50.54194  ? 263 ASN B ND2 1 
ATOM   2791 N  N   . LEU B 1 171 ? 23.68857  14.93878  -6.51603  1.000 42.81823  ? 264 LEU B N   1 
ATOM   2792 C  CA  . LEU B 1 171 ? 23.96138  15.91815  -7.56459  1.000 40.54424  ? 264 LEU B CA  1 
ATOM   2793 C  C   . LEU B 1 171 ? 24.30044  17.28271  -6.98307  1.000 43.89768  ? 264 LEU B C   1 
ATOM   2794 O  O   . LEU B 1 171 ? 23.54314  17.82004  -6.17022  1.000 43.83067  ? 264 LEU B O   1 
ATOM   2795 C  CB  . LEU B 1 171 ? 22.75324  16.05150  -8.48659  1.000 43.32049  ? 264 LEU B CB  1 
ATOM   2796 C  CG  . LEU B 1 171 ? 22.91058  17.10145  -9.58035  1.000 51.57264  ? 264 LEU B CG  1 
ATOM   2797 C  CD1 . LEU B 1 171 ? 23.60968  16.49078  -10.76691 1.000 43.80208  ? 264 LEU B CD1 1 
ATOM   2798 C  CD2 . LEU B 1 171 ? 21.55928  17.64053  -9.99132  1.000 55.43877  ? 264 LEU B CD2 1 
ATOM   2799 N  N   . LEU B 1 172 ? 25.43507  17.84874  -7.41365  1.000 43.02728  ? 265 LEU B N   1 
ATOM   2800 C  CA  . LEU B 1 172 ? 25.77532  19.23851  -7.12544  1.000 40.65632  ? 265 LEU B CA  1 
ATOM   2801 C  C   . LEU B 1 172 ? 25.73033  20.13469  -8.34817  1.000 43.72109  ? 265 LEU B C   1 
ATOM   2802 O  O   . LEU B 1 172 ? 25.56643  21.34832  -8.19472  1.000 44.33627  ? 265 LEU B O   1 
ATOM   2803 C  CB  . LEU B 1 172 ? 27.17876  19.34480  -6.51729  1.000 44.26327  ? 265 LEU B CB  1 
ATOM   2804 C  CG  . LEU B 1 172 ? 27.46089  18.47999  -5.29440  1.000 44.29019  ? 265 LEU B CG  1 
ATOM   2805 C  CD1 . LEU B 1 172 ? 28.93098  18.53346  -4.95002  1.000 38.07986  ? 265 LEU B CD1 1 
ATOM   2806 C  CD2 . LEU B 1 172 ? 26.61596  18.96032  -4.13758  1.000 41.39523  ? 265 LEU B CD2 1 
ATOM   2807 N  N   . GLY B 1 173 ? 25.87178  19.57619  -9.54619  1.000 39.42869  ? 266 GLY B N   1 
ATOM   2808 C  CA  . GLY B 1 173 ? 25.88580  20.38138  -10.75405 1.000 39.44663  ? 266 GLY B CA  1 
ATOM   2809 C  C   . GLY B 1 173 ? 25.89355  19.49699  -11.97734 1.000 42.61370  ? 266 GLY B C   1 
ATOM   2810 O  O   . GLY B 1 173 ? 26.31424  18.33266  -11.91829 1.000 39.81591  ? 266 GLY B O   1 
ATOM   2811 N  N   . ARG B 1 174 ? 25.41908  20.06560  -13.09465 1.000 39.33774  ? 267 ARG B N   1 
ATOM   2812 C  CA  . ARG B 1 174 ? 25.31073  19.31031  -14.34341 1.000 36.70946  ? 267 ARG B CA  1 
ATOM   2813 C  C   . ARG B 1 174 ? 25.44162  20.22684  -15.55406 1.000 41.75394  ? 267 ARG B C   1 
ATOM   2814 O  O   . ARG B 1 174 ? 24.90956  21.33929  -15.56362 1.000 43.69649  ? 267 ARG B O   1 
ATOM   2815 C  CB  . ARG B 1 174 ? 23.98066  18.55747  -14.44140 1.000 35.17030  ? 267 ARG B CB  1 
ATOM   2816 C  CG  . ARG B 1 174 ? 23.98130  17.49794  -15.53848 1.000 45.67769  ? 267 ARG B CG  1 
ATOM   2817 C  CD  . ARG B 1 174 ? 22.61314  16.88520  -15.79250 1.000 47.37265  ? 267 ARG B CD  1 
ATOM   2818 N  NE  . ARG B 1 174 ? 22.09811  16.15018  -14.64366 1.000 44.38478  ? 267 ARG B NE  1 
ATOM   2819 C  CZ  . ARG B 1 174 ? 21.13621  16.59726  -13.85017 1.000 47.20676  ? 267 ARG B CZ  1 
ATOM   2820 N  NH1 . ARG B 1 174 ? 20.59786  17.79623  -14.02314 1.000 49.55529  ? 267 ARG B NH1 1 
ATOM   2821 N  NH2 . ARG B 1 174 ? 20.70799  15.82709  -12.85632 1.000 50.10030  ? 267 ARG B NH2 1 
ATOM   2822 N  N   . ASP B 1 175 ? 26.13046  19.73005  -16.58004 1.000 42.31648  ? 268 ASP B N   1 
ATOM   2823 C  CA  . ASP B 1 175 ? 26.25582  20.38001  -17.88063 1.000 40.29268  ? 268 ASP B CA  1 
ATOM   2824 C  C   . ASP B 1 175 ? 26.44185  19.26667  -18.90527 1.000 47.58324  ? 268 ASP B C   1 
ATOM   2825 O  O   . ASP B 1 175 ? 26.63766  18.09885  -18.54614 1.000 41.35096  ? 268 ASP B O   1 
ATOM   2826 C  CB  . ASP B 1 175 ? 27.42118  21.38849  -17.89552 1.000 38.05187  ? 268 ASP B CB  1 
ATOM   2827 C  CG  . ASP B 1 175 ? 27.33017  22.40527  -19.03670 1.000 47.31887  ? 268 ASP B CG  1 
ATOM   2828 O  OD1 . ASP B 1 175 ? 26.44741  22.28350  -19.90592 1.000 43.26812  ? 268 ASP B OD1 1 
ATOM   2829 O  OD2 . ASP B 1 175 ? 28.14975  23.35401  -19.05019 1.000 52.65630  ? 268 ASP B OD2 1 
ATOM   2830 N  N   . SER B 1 176 ? 26.35789  19.61898  -20.18635 1.000 43.31738  ? 269 SER B N   1 
ATOM   2831 C  CA  . SER B 1 176 ? 26.38045  18.57124  -21.19702 1.000 35.37524  ? 269 SER B CA  1 
ATOM   2832 C  C   . SER B 1 176 ? 26.76153  19.15951  -22.54619 1.000 39.16273  ? 269 SER B C   1 
ATOM   2833 O  O   . SER B 1 176 ? 26.64557  20.36600  -22.78840 1.000 37.25631  ? 269 SER B O   1 
ATOM   2834 C  CB  . SER B 1 176 ? 25.02695  17.84405  -21.28192 1.000 32.45705  ? 269 SER B CB  1 
ATOM   2835 O  OG  . SER B 1 176 ? 24.02371  18.63498  -21.89075 1.000 42.69103  ? 269 SER B OG  1 
ATOM   2836 N  N   . PHE B 1 177 ? 27.23035  18.28124  -23.42023 1.000 39.43224  ? 270 PHE B N   1 
ATOM   2837 C  CA  . PHE B 1 177 ? 27.53441  18.65073  -24.78989 1.000 39.70611  ? 270 PHE B CA  1 
ATOM   2838 C  C   . PHE B 1 177 ? 27.33972  17.42819  -25.67174 1.000 43.25197  ? 270 PHE B C   1 
ATOM   2839 O  O   . PHE B 1 177 ? 27.46996  16.28764  -25.21840 1.000 37.53108  ? 270 PHE B O   1 
ATOM   2840 C  CB  . PHE B 1 177 ? 28.96077  19.18549  -24.93455 1.000 32.94320  ? 270 PHE B CB  1 
ATOM   2841 C  CG  . PHE B 1 177 ? 30.01300  18.29395  -24.33181 1.000 35.73506  ? 270 PHE B CG  1 
ATOM   2842 C  CD1 . PHE B 1 177 ? 30.30993  18.35548  -22.98547 1.000 38.27670  ? 270 PHE B CD1 1 
ATOM   2843 C  CD2 . PHE B 1 177 ? 30.73610  17.42196  -25.12348 1.000 42.40418  ? 270 PHE B CD2 1 
ATOM   2844 C  CE1 . PHE B 1 177 ? 31.29444  17.55655  -22.43739 1.000 41.69692  ? 270 PHE B CE1 1 
ATOM   2845 C  CE2 . PHE B 1 177 ? 31.72456  16.61690  -24.57713 1.000 40.73538  ? 270 PHE B CE2 1 
ATOM   2846 C  CZ  . PHE B 1 177 ? 32.00145  16.69222  -23.22983 1.000 39.12225  ? 270 PHE B CZ  1 
ATOM   2847 N  N   . GLU B 1 178 ? 27.01194  17.68293  -26.93078 1.000 35.45025  ? 271 GLU B N   1 
ATOM   2848 C  CA  . GLU B 1 178 ? 26.87351  16.62905  -27.91031 1.000 34.45567  ? 271 GLU B CA  1 
ATOM   2849 C  C   . GLU B 1 178 ? 28.26464  16.27339  -28.44050 1.000 37.53742  ? 271 GLU B C   1 
ATOM   2850 O  O   . GLU B 1 178 ? 29.20662  17.07071  -28.36505 1.000 36.54336  ? 271 GLU B O   1 
ATOM   2851 C  CB  . GLU B 1 178 ? 25.94103  17.10176  -29.03039 1.000 38.76416  ? 271 GLU B CB  1 
ATOM   2852 C  CG  . GLU B 1 178 ? 25.80207  16.17115  -30.22929 1.000 47.45102  ? 271 GLU B CG  1 
ATOM   2853 C  CD  . GLU B 1 178 ? 24.66699  16.53749  -31.18284 1.000 56.14270  ? 271 GLU B CD  1 
ATOM   2854 O  OE1 . GLU B 1 178 ? 23.76954  17.33298  -30.80701 1.000 52.90668  ? 271 GLU B OE1 1 
ATOM   2855 O  OE2 . GLU B 1 178 ? 24.69491  16.02941  -32.33118 1.000 55.31589  ? 271 GLU B OE2 1 
ATOM   2856 N  N   . VAL B 1 179 ? 28.42822  15.03802  -28.89956 1.000 35.00663  ? 272 VAL B N   1 
ATOM   2857 C  CA  . VAL B 1 179 ? 29.72231  14.55802  -29.36632 1.000 32.71799  ? 272 VAL B CA  1 
ATOM   2858 C  C   . VAL B 1 179 ? 29.54190  13.84725  -30.69534 1.000 40.70095  ? 272 VAL B C   1 
ATOM   2859 O  O   . VAL B 1 179 ? 28.62052  13.04102  -30.86445 1.000 43.04283  ? 272 VAL B O   1 
ATOM   2860 C  CB  . VAL B 1 179 ? 30.39205  13.60227  -28.36372 1.000 39.09430  ? 272 VAL B CB  1 
ATOM   2861 C  CG1 . VAL B 1 179 ? 31.74856  13.12843  -28.90181 1.000 37.33488  ? 272 VAL B CG1 1 
ATOM   2862 C  CG2 . VAL B 1 179 ? 30.56502  14.25431  -27.03380 1.000 39.46202  ? 272 VAL B CG2 1 
ATOM   2863 N  N   . ARG B 1 180 ? 30.43836  14.12511  -31.63089 1.000 37.25719  ? 273 ARG B N   1 
ATOM   2864 C  CA  . ARG B 1 180 ? 30.60462  13.28390  -32.80337 1.000 44.40876  ? 273 ARG B CA  1 
ATOM   2865 C  C   . ARG B 1 180 ? 32.04776  12.82011  -32.87971 1.000 43.13052  ? 273 ARG B C   1 
ATOM   2866 O  O   . ARG B 1 180 ? 32.96211  13.64352  -32.96448 1.000 43.40410  ? 273 ARG B O   1 
ATOM   2867 C  CB  . ARG B 1 180 ? 30.20815  14.00742  -34.07919 1.000 40.06572  ? 273 ARG B CB  1 
ATOM   2868 C  CG  . ARG B 1 180 ? 30.40799  13.14128  -35.28702 1.000 43.02786  ? 273 ARG B CG  1 
ATOM   2869 C  CD  . ARG B 1 180 ? 30.60864  13.98537  -36.51399 1.000 49.93983  ? 273 ARG B CD  1 
ATOM   2870 N  NE  . ARG B 1 180 ? 30.77601  13.22194  -37.74289 1.000 57.26265  ? 273 ARG B NE  1 
ATOM   2871 C  CZ  . ARG B 1 180 ? 29.93674  12.31746  -38.22873 1.000 69.60941  ? 273 ARG B CZ  1 
ATOM   2872 N  NH1 . ARG B 1 180 ? 28.75487  12.09538  -37.67996 1.000 70.28067  ? 273 ARG B NH1 1 
ATOM   2873 N  NH2 . ARG B 1 180 ? 30.28059  11.64477  -39.32442 1.000 75.75584  ? 273 ARG B NH2 1 
ATOM   2874 N  N   . VAL B 1 181 ? 32.23419  11.50400  -32.87760 1.000 35.74309  ? 274 VAL B N   1 
ATOM   2875 C  CA  . VAL B 1 181 ? 33.53842  10.86477  -33.01465 1.000 43.91971  ? 274 VAL B CA  1 
ATOM   2876 C  C   . VAL B 1 181 ? 33.69689  10.45730  -34.47816 1.000 49.32744  ? 274 VAL B C   1 
ATOM   2877 O  O   . VAL B 1 181 ? 32.88969  9.67577   -35.00181 1.000 44.57289  ? 274 VAL B O   1 
ATOM   2878 C  CB  . VAL B 1 181 ? 33.64948  9.64818   -32.07647 1.000 47.61162  ? 274 VAL B CB  1 
ATOM   2879 C  CG1 . VAL B 1 181 ? 35.06633  9.15764   -31.99120 1.000 43.22751  ? 274 VAL B CG1 1 
ATOM   2880 C  CG2 . VAL B 1 181 ? 33.13872  10.01520  -30.69488 1.000 38.96698  ? 274 VAL B CG2 1 
ATOM   2881 N  N   . CYS B 1 182 ? 34.73068  10.97528  -35.13906 1.000 45.83883  ? 275 CYS B N   1 
ATOM   2882 C  CA  . CYS B 1 182 ? 34.83612  10.85238  -36.58563 1.000 47.33486  ? 275 CYS B CA  1 
ATOM   2883 C  C   . CYS B 1 182 ? 36.30102  10.96699  -36.99107 1.000 53.74156  ? 275 CYS B C   1 
ATOM   2884 O  O   . CYS B 1 182 ? 37.17716  11.25389  -36.16979 1.000 51.90710  ? 275 CYS B O   1 
ATOM   2885 C  CB  . CYS B 1 182 ? 33.97314  11.90691  -37.29462 1.000 56.24243  ? 275 CYS B CB  1 
ATOM   2886 S  SG  . CYS B 1 182 ? 34.24451  13.64250  -36.74935 1.000 50.43971  ? 275 CYS B SG  1 
ATOM   2887 N  N   . ALA B 1 183 ? 36.55520  10.72465  -38.28276 1.000 56.45414  ? 276 ALA B N   1 
ATOM   2888 C  CA  . ALA B 1 183 ? 37.91675  10.71468  -38.80992 1.000 49.70541  ? 276 ALA B CA  1 
ATOM   2889 C  C   . ALA B 1 183 ? 38.42369  12.10391  -39.14325 1.000 50.49868  ? 276 ALA B C   1 
ATOM   2890 O  O   . ALA B 1 183 ? 39.61814  12.37439  -38.98008 1.000 54.78141  ? 276 ALA B O   1 
ATOM   2891 C  CB  . ALA B 1 183 ? 37.99105  9.84941   -40.06645 1.000 60.57089  ? 276 ALA B CB  1 
ATOM   2892 N  N   . CYS B 1 184 ? 37.54117  12.98638  -39.61245 1.000 47.27198  ? 277 CYS B N   1 
ATOM   2893 C  CA  . CYS B 1 184 ? 37.90694  14.34191  -40.03174 1.000 63.53826  ? 277 CYS B CA  1 
ATOM   2894 C  C   . CYS B 1 184 ? 37.03420  15.33429  -39.26897 1.000 57.49898  ? 277 CYS B C   1 
ATOM   2895 O  O   . CYS B 1 184 ? 36.04939  15.85676  -39.81215 1.000 56.40222  ? 277 CYS B O   1 
ATOM   2896 C  CB  . CYS B 1 184 ? 37.76201  14.49952  -41.54973 1.000 61.48430  ? 277 CYS B CB  1 
ATOM   2897 S  SG  . CYS B 1 184 ? 38.63710  13.21355  -42.49558 1.000 76.62288  ? 277 CYS B SG  1 
ATOM   2898 N  N   . PRO B 1 185 ? 37.34937  15.58662  -37.98228 1.000 58.25476  ? 278 PRO B N   1 
ATOM   2899 C  CA  . PRO B 1 185 ? 36.50654  16.49629  -37.17730 1.000 52.12844  ? 278 PRO B CA  1 
ATOM   2900 C  C   . PRO B 1 185 ? 36.40873  17.91693  -37.70196 1.000 50.82185  ? 278 PRO B C   1 
ATOM   2901 O  O   . PRO B 1 185 ? 35.33008  18.51901  -37.62154 1.000 51.24013  ? 278 PRO B O   1 
ATOM   2902 C  CB  . PRO B 1 185 ? 37.17819  16.45790  -35.79347 1.000 55.78268  ? 278 PRO B CB  1 
ATOM   2903 C  CG  . PRO B 1 185 ? 38.53426  15.84980  -36.01312 1.000 56.68163  ? 278 PRO B CG  1 
ATOM   2904 C  CD  . PRO B 1 185 ? 38.34103  14.89170  -37.14518 1.000 53.02555  ? 278 PRO B CD  1 
ATOM   2905 N  N   . GLY B 1 186 ? 37.49820  18.48040  -38.22414 1.000 60.13996  ? 279 GLY B N   1 
ATOM   2906 C  CA  . GLY B 1 186 ? 37.42154  19.83163  -38.75520 1.000 57.36516  ? 279 GLY B CA  1 
ATOM   2907 C  C   . GLY B 1 186 ? 36.42948  19.94371  -39.89555 1.000 60.16115  ? 279 GLY B C   1 
ATOM   2908 O  O   . GLY B 1 186 ? 35.62877  20.88312  -39.94897 1.000 60.05040  ? 279 GLY B O   1 
ATOM   2909 N  N   . ARG B 1 187 ? 36.44425  18.96365  -40.80156 1.000 52.52403  ? 280 ARG B N   1 
ATOM   2910 C  CA  . ARG B 1 187 ? 35.53101  18.99039  -41.93745 1.000 56.19370  ? 280 ARG B CA  1 
ATOM   2911 C  C   . ARG B 1 187 ? 34.08700  18.80685  -41.48782 1.000 58.28012  ? 280 ARG B C   1 
ATOM   2912 O  O   . ARG B 1 187 ? 33.19111  19.52517  -41.95122 1.000 54.40160  ? 280 ARG B O   1 
ATOM   2913 C  CB  . ARG B 1 187 ? 35.94054  17.91570  -42.95343 1.000 62.30746  ? 280 ARG B CB  1 
ATOM   2914 C  CG  . ARG B 1 187 ? 34.80562  17.32935  -43.79653 1.000 58.23446  ? 280 ARG B CG  1 
ATOM   2915 N  N   . ASP B 1 188 ? 33.84220  17.85810  -40.57571 1.000 58.02272  ? 281 ASP B N   1 
ATOM   2916 C  CA  . ASP B 1 188 ? 32.46978  17.59338  -40.15815 1.000 52.82484  ? 281 ASP B CA  1 
ATOM   2917 C  C   . ASP B 1 188 ? 31.91044  18.74232  -39.33584 1.000 51.54947  ? 281 ASP B C   1 
ATOM   2918 O  O   . ASP B 1 188 ? 30.69763  18.97074  -39.35146 1.000 51.32825  ? 281 ASP B O   1 
ATOM   2919 C  CB  . ASP B 1 188 ? 32.38971  16.28241  -39.38543 1.000 49.03079  ? 281 ASP B CB  1 
ATOM   2920 C  CG  . ASP B 1 188 ? 32.61519  15.06803  -40.27786 1.000 63.91305  ? 281 ASP B CG  1 
ATOM   2921 O  OD1 . ASP B 1 188 ? 32.98588  13.99335  -39.75170 1.000 63.69198  ? 281 ASP B OD1 1 
ATOM   2922 O  OD2 . ASP B 1 188 ? 32.43193  15.19063  -41.50830 1.000 60.69295  ? 281 ASP B OD2 1 
ATOM   2923 N  N   . ARG B 1 189 ? 32.77045  19.48158  -38.62682 1.000 45.08655  ? 282 ARG B N   1 
ATOM   2924 C  CA  . ARG B 1 189 ? 32.29121  20.66873  -37.93333 1.000 45.86495  ? 282 ARG B CA  1 
ATOM   2925 C  C   . ARG B 1 189 ? 31.87666  21.74236  -38.93242 1.000 55.37505  ? 282 ARG B C   1 
ATOM   2926 O  O   . ARG B 1 189 ? 30.79590  22.33267  -38.80747 1.000 54.92565  ? 282 ARG B O   1 
ATOM   2927 C  CB  . ARG B 1 189 ? 33.35862  21.20111  -36.97566 1.000 50.17292  ? 282 ARG B CB  1 
ATOM   2928 C  CG  . ARG B 1 189 ? 32.89947  22.45678  -36.21946 1.000 50.35922  ? 282 ARG B CG  1 
ATOM   2929 C  CD  . ARG B 1 189 ? 33.96289  23.01613  -35.29398 1.000 48.25261  ? 282 ARG B CD  1 
ATOM   2930 N  NE  . ARG B 1 189 ? 33.69000  24.41210  -34.98749 1.000 45.31354  ? 282 ARG B NE  1 
ATOM   2931 C  CZ  . ARG B 1 189 ? 34.52469  25.22819  -34.35801 1.000 46.36819  ? 282 ARG B CZ  1 
ATOM   2932 N  NH1 . ARG B 1 189 ? 35.71510  24.82025  -33.95226 1.000 44.08564  ? 282 ARG B NH1 1 
ATOM   2933 N  NH2 . ARG B 1 189 ? 34.15760  26.49102  -34.13758 1.000 40.58934  ? 282 ARG B NH2 1 
ATOM   2934 N  N   . ARG B 1 190 ? 32.71770  21.98896  -39.94738 1.000 53.94436  ? 283 ARG B N   1 
ATOM   2935 C  CA  . ARG B 1 190 ? 32.39164  22.97881  -40.97396 1.000 57.20295  ? 283 ARG B CA  1 
ATOM   2936 C  C   . ARG B 1 190 ? 31.09107  22.62723  -41.67772 1.000 52.34800  ? 283 ARG B C   1 
ATOM   2937 O  O   . ARG B 1 190 ? 30.24133  23.49415  -41.91026 1.000 60.93720  ? 283 ARG B O   1 
ATOM   2938 C  CB  . ARG B 1 190 ? 33.53440  23.07745  -41.98453 1.000 57.03699  ? 283 ARG B CB  1 
ATOM   2939 N  N   . THR B 1 191 ? 30.90345  21.34633  -41.97505 1.000 55.08432  ? 284 THR B N   1 
ATOM   2940 C  CA  . THR B 1 191 ? 29.68508  20.88979  -42.63088 1.000 61.12758  ? 284 THR B CA  1 
ATOM   2941 C  C   . THR B 1 191 ? 28.44996  21.12997  -41.76700 1.000 62.21283  ? 284 THR B C   1 
ATOM   2942 O  O   . THR B 1 191 ? 27.46905  21.72317  -42.22631 1.000 60.89511  ? 284 THR B O   1 
ATOM   2943 C  CB  . THR B 1 191 ? 29.83297  19.41022  -42.97347 1.000 59.78654  ? 284 THR B CB  1 
ATOM   2944 O  OG1 . THR B 1 191 ? 31.03639  19.23449  -43.73146 1.000 52.05696  ? 284 THR B OG1 1 
ATOM   2945 C  CG2 . THR B 1 191 ? 28.62843  18.91424  -43.76570 1.000 55.32561  ? 284 THR B CG2 1 
ATOM   2946 N  N   . GLU B 1 192 ? 28.47694  20.67809  -40.50935 1.000 61.71964  ? 285 GLU B N   1 
ATOM   2947 C  CA  . GLU B 1 192 ? 27.28690  20.80337  -39.67156 1.000 56.51592  ? 285 GLU B CA  1 
ATOM   2948 C  C   . GLU B 1 192 ? 26.99613  22.25604  -39.31439 1.000 53.69050  ? 285 GLU B C   1 
ATOM   2949 O  O   . GLU B 1 192 ? 25.82796  22.62385  -39.13752 1.000 50.40954  ? 285 GLU B O   1 
ATOM   2950 C  CB  . GLU B 1 192 ? 27.42979  19.94902  -38.40899 1.000 51.37016  ? 285 GLU B CB  1 
ATOM   2951 C  CG  . GLU B 1 192 ? 27.59485  18.46099  -38.69737 1.000 59.13831  ? 285 GLU B CG  1 
ATOM   2952 C  CD  . GLU B 1 192 ? 27.19792  17.57128  -37.53270 1.000 65.42754  ? 285 GLU B CD  1 
ATOM   2953 O  OE1 . GLU B 1 192 ? 27.61443  16.38849  -37.52309 1.000 61.12388  ? 285 GLU B OE1 1 
ATOM   2954 O  OE2 . GLU B 1 192 ? 26.46882  18.04494  -36.63077 1.000 64.27188  ? 285 GLU B OE2 1 
ATOM   2955 N  N   . GLU B 1 193 ? 28.03056  23.09549  -39.21184 1.000 51.81511  ? 286 GLU B N   1 
ATOM   2956 C  CA  . GLU B 1 193 ? 27.79160  24.50946  -38.92701 1.000 58.77176  ? 286 GLU B CA  1 
ATOM   2957 C  C   . GLU B 1 193 ? 27.16199  25.21648  -40.12382 1.000 60.89365  ? 286 GLU B C   1 
ATOM   2958 O  O   . GLU B 1 193 ? 26.30412  26.09079  -39.95033 1.000 66.22170  ? 286 GLU B O   1 
ATOM   2959 C  CB  . GLU B 1 193 ? 29.09209  25.19724  -38.50181 1.000 50.61980  ? 286 GLU B CB  1 
ATOM   2960 C  CG  . GLU B 1 193 ? 29.49837  24.90592  -37.04966 1.000 45.90195  ? 286 GLU B CG  1 
ATOM   2961 C  CD  . GLU B 1 193 ? 30.80367  25.57685  -36.65727 1.000 55.67187  ? 286 GLU B CD  1 
ATOM   2962 O  OE1 . GLU B 1 193 ? 31.48343  26.11151  -37.56366 1.000 55.82767  ? 286 GLU B OE1 1 
ATOM   2963 O  OE2 . GLU B 1 193 ? 31.14438  25.58158  -35.44450 1.000 47.07499  ? 286 GLU B OE2 1 
ATOM   2964 N  N   . GLU B 1 194 ? 27.56758  24.84763  -41.34457 1.000 61.13562  ? 287 GLU B N   1 
ATOM   2965 C  CA  . GLU B 1 194 ? 26.92112  25.39416  -42.53655 1.000 66.97474  ? 287 GLU B CA  1 
ATOM   2966 C  C   . GLU B 1 194 ? 25.45917  24.97522  -42.60790 1.000 62.60828  ? 287 GLU B C   1 
ATOM   2967 O  O   . GLU B 1 194 ? 24.59135  25.77468  -42.97674 1.000 73.19041  ? 287 GLU B O   1 
ATOM   2968 C  CB  . GLU B 1 194 ? 27.66483  24.95040  -43.79607 1.000 57.25559  ? 287 GLU B CB  1 
ATOM   2969 N  N   . ASN B 1 195 ? 25.17192  23.72566  -42.24666 1.000 65.82224  ? 288 ASN B N   1 
ATOM   2970 C  CA  . ASN B 1 195 ? 23.79766  23.23621  -42.25028 1.000 68.89320  ? 288 ASN B CA  1 
ATOM   2971 C  C   . ASN B 1 195 ? 22.93598  24.03234  -41.28167 1.000 73.96641  ? 288 ASN B C   1 
ATOM   2972 O  O   . ASN B 1 195 ? 21.75721  24.29262  -41.55536 1.000 80.26219  ? 288 ASN B O   1 
ATOM   2973 C  CB  . ASN B 1 195 ? 23.75075  21.75445  -41.87358 1.000 53.92245  ? 288 ASN B CB  1 
ATOM   2974 C  CG  . ASN B 1 195 ? 24.43112  20.83087  -42.89002 1.000 74.55644  ? 288 ASN B CG  1 
ATOM   2975 O  OD1 . ASN B 1 195 ? 24.20322  19.62010  -42.86164 1.000 68.24733  ? 288 ASN B OD1 1 
ATOM   2976 N  ND2 . ASN B 1 195 ? 25.26614  21.38036  -43.76890 1.000 76.41892  ? 288 ASN B ND2 1 
ATOM   2977 N  N   . LEU B 1 196 ? 23.50704  24.41019  -40.13471 1.000 69.21193  ? 289 LEU B N   1 
ATOM   2978 C  CA  . LEU B 1 196 ? 22.74668  25.15314  -39.13600 1.000 72.16196  ? 289 LEU B CA  1 
ATOM   2979 C  C   . LEU B 1 196 ? 22.33587  26.51856  -39.66659 1.000 69.80281  ? 289 LEU B C   1 
ATOM   2980 O  O   . LEU B 1 196 ? 21.20653  26.96239  -39.42654 1.000 79.18444  ? 289 LEU B O   1 
ATOM   2981 C  CB  . LEU B 1 196 ? 23.55237  25.29024  -37.84260 1.000 69.15741  ? 289 LEU B CB  1 
ATOM   2982 C  CG  . LEU B 1 196 ? 22.92673  26.13031  -36.72150 1.000 65.30825  ? 289 LEU B CG  1 
ATOM   2983 C  CD1 . LEU B 1 196 ? 21.61456  25.52264  -36.20400 1.000 47.73263  ? 289 LEU B CD1 1 
ATOM   2984 C  CD2 . LEU B 1 196 ? 23.91544  26.32650  -35.58002 1.000 51.93589  ? 289 LEU B CD2 1 
ATOM   2985 N  N   . ARG B 1 197 ? 23.23408  27.18879  -40.40235 1.000 74.62743  ? 290 ARG B N   1 
ATOM   2986 C  CA  . ARG B 1 197 ? 22.88991  28.46106  -41.03986 1.000 78.69389  ? 290 ARG B CA  1 
ATOM   2987 C  C   . ARG B 1 197 ? 21.76417  28.29825  -42.05698 1.000 79.86872  ? 290 ARG B C   1 
ATOM   2988 O  O   . ARG B 1 197 ? 20.94695  29.20978  -42.22349 1.000 72.58092  ? 290 ARG B O   1 
ATOM   2989 C  CB  . ARG B 1 197 ? 24.12331  29.06901  -41.71203 1.000 66.63447  ? 290 ARG B CB  1 
ATOM   2990 N  N   . LYS B 1 198 ? 21.69600  27.14933  -42.73056 1.000 79.96384  ? 291 LYS B N   1 
ATOM   2991 C  CA  . LYS B 1 198 ? 20.64692  26.88291  -43.71223 1.000 78.27541  ? 291 LYS B CA  1 
ATOM   2992 C  C   . LYS B 1 198 ? 19.38128  26.32576  -43.05907 1.000 73.98292  ? 291 LYS B C   1 
ATOM   2993 O  O   . LYS B 1 198 ? 18.85119  26.90198  -42.10601 1.000 82.62018  ? 291 LYS B O   1 
ATOM   2994 C  CB  . LYS B 1 198 ? 21.15413  25.90829  -44.77783 1.000 65.66110  ? 291 LYS B CB  1 
HETATM 2995 C  C1  . YM0 C 2 .   ? 4.87751   29.40340  -6.65969  1.000 52.09182  ? 401 YM0 A C1  1 
HETATM 2996 C  C2  . YM0 C 2 .   ? 4.89879   30.63286  -7.36932  1.000 50.20748  ? 401 YM0 A C2  1 
HETATM 2997 C  C3  . YM0 C 2 .   ? 3.60548   29.69721  -9.01890  1.000 47.05399  ? 401 YM0 A C3  1 
HETATM 2998 C  C4  . YM0 C 2 .   ? 3.59515   28.49872  -8.33277  1.000 53.91899  ? 401 YM0 A C4  1 
HETATM 2999 C  C5  . YM0 C 2 .   ? 5.57957   31.80345  -6.85655  1.000 58.88068  ? 401 YM0 A C5  1 
HETATM 3000 C  C6  . YM0 C 2 .   ? 2.93803   29.86734  -10.29393 1.000 52.98331  ? 401 YM0 A C6  1 
HETATM 3001 N  N1  . YM0 C 2 .   ? 4.25974   30.77152  -8.54600  1.000 46.88528  ? 401 YM0 A N1  1 
HETATM 3002 N  N2  . YM0 C 2 .   ? 4.21929   28.34930  -7.16272  1.000 52.69184  ? 401 YM0 A N2  1 
HETATM 3003 N  N3  . YM0 C 2 .   ? 5.50930   29.26318  -5.48333  1.000 47.10162  ? 401 YM0 A N3  1 
HETATM 3004 N  N4  . YM0 C 2 .   ? 6.16109   32.71439  -6.47336  1.000 64.77030  ? 401 YM0 A N4  1 
HETATM 3005 N  N5  . YM0 C 2 .   ? 2.43760   29.99118  -11.31806 1.000 56.73456  ? 401 YM0 A N5  1 
HETATM 3006 C  C1  . YM0 D 2 .   ? 10.25987  3.73108   -32.67668 1.000 79.40998  ? 402 YM0 A C1  1 
HETATM 3007 C  C2  . YM0 D 2 .   ? 9.83858   3.73524   -34.03484 1.000 79.07327  ? 402 YM0 A C2  1 
HETATM 3008 C  C3  . YM0 D 2 .   ? 7.81710   4.62632   -33.39343 1.000 65.85693  ? 402 YM0 A C3  1 
HETATM 3009 C  C4  . YM0 D 2 .   ? 8.22566   4.61095   -32.07170 1.000 66.80149  ? 402 YM0 A C4  1 
HETATM 3010 C  C5  . YM0 D 2 .   ? 10.70788  3.25813   -35.08974 1.000 85.45417  ? 402 YM0 A C5  1 
HETATM 3011 C  C6  . YM0 D 2 .   ? 6.48668   5.05673   -33.78667 1.000 61.01555  ? 402 YM0 A C6  1 
HETATM 3012 N  N1  . YM0 D 2 .   ? 8.61495   4.17789   -34.37786 1.000 76.64336  ? 402 YM0 A N1  1 
HETATM 3013 N  N2  . YM0 D 2 .   ? 9.43474   4.17636   -31.71717 1.000 66.13714  ? 402 YM0 A N2  1 
HETATM 3014 N  N3  . YM0 D 2 .   ? 11.47902  3.28795   -32.33020 1.000 73.26145  ? 402 YM0 A N3  1 
HETATM 3015 N  N4  . YM0 D 2 .   ? 11.37131  2.83141   -35.92572 1.000 93.32923  ? 402 YM0 A N4  1 
HETATM 3016 N  N5  . YM0 D 2 .   ? 5.43037   5.39761   -34.09871 1.000 58.81094  ? 402 YM0 A N5  1 
HETATM 3017 N  N1  . EPE E 3 .   ? 3.34504   13.56170  -39.64333 1.000 81.66408  ? 403 EPE A N1  1 
HETATM 3018 C  C2  . EPE E 3 .   ? 3.02242   12.16912  -39.99051 1.000 73.04573  ? 403 EPE A C2  1 
HETATM 3019 C  C3  . EPE E 3 .   ? 4.30831   11.35665  -40.06489 1.000 78.84466  ? 403 EPE A C3  1 
HETATM 3020 N  N4  . EPE E 3 .   ? 5.46797   12.15006  -40.44446 1.000 79.27867  ? 403 EPE A N4  1 
HETATM 3021 C  C5  . EPE E 3 .   ? 5.37890   13.48589  -41.01245 1.000 79.57973  ? 403 EPE A C5  1 
HETATM 3022 C  C6  . EPE E 3 .   ? 4.03547   14.17429  -40.78627 1.000 80.33226  ? 403 EPE A C6  1 
HETATM 3023 C  C9  . EPE E 3 .   ? 2.07601   14.25724  -39.40440 1.000 70.84760  ? 403 EPE A C9  1 
HETATM 3024 C  C10 . EPE E 3 .   ? 2.29020   15.74460  -39.17815 1.000 75.79313  ? 403 EPE A C10 1 
HETATM 3025 S  S   . EPE E 3 .   ? 1.10276   16.56759  -40.26346 1.000 113.85320 ? 403 EPE A S   1 
HETATM 3026 O  O1S . EPE E 3 .   ? 1.73722   16.88820  -41.54261 1.000 96.18821  ? 403 EPE A O1S 1 
HETATM 3027 O  O2S . EPE E 3 .   ? 0.00616   15.61039  -40.45114 1.000 88.92198  ? 403 EPE A O2S 1 
HETATM 3028 O  O3S . EPE E 3 .   ? 0.60030   17.80603  -39.66971 1.000 90.52963  ? 403 EPE A O3S 1 
HETATM 3029 C  C1  . PEG F 4 .   ? 10.24082  28.38178  -28.04939 1.000 58.13360  ? 404 PEG A C1  1 
HETATM 3030 C  C2  . PEG F 4 .   ? 8.81425   28.16222  -28.46270 1.000 67.29042  ? 404 PEG A C2  1 
HETATM 3031 O  O2  . PEG F 4 .   ? 7.96857   29.23326  -28.02847 1.000 71.89283  ? 404 PEG A O2  1 
HETATM 3032 C  C3  . PEG F 4 .   ? 6.62148   28.80327  -27.83468 1.000 58.99587  ? 404 PEG A C3  1 
HETATM 3033 C  C4  . PEG F 4 .   ? 5.70065   29.94849  -27.54991 1.000 64.02791  ? 404 PEG A C4  1 
HETATM 3034 O  O4  . PEG F 4 .   ? 5.58698   30.83805  -28.65682 1.000 66.96021  ? 404 PEG A O4  1 
HETATM 3035 ZN ZN  . ZN  G 5 .   ? 0.88434   8.55880   -32.60671 1.000 45.69109  ? 405 ZN  A ZN  1 
HETATM 3036 N  N1  . EPE H 3 .   ? 35.90513  5.05065   -40.18604 1.000 82.68453  ? 401 EPE B N1  1 
HETATM 3037 C  C2  . EPE H 3 .   ? 35.54453  3.67724   -40.59026 1.000 83.39167  ? 401 EPE B C2  1 
HETATM 3038 C  C3  . EPE H 3 .   ? 36.64249  2.68266   -40.21756 1.000 77.32694  ? 401 EPE B C3  1 
HETATM 3039 N  N4  . EPE H 3 .   ? 37.96887  3.19538   -40.51147 1.000 81.17247  ? 401 EPE B N4  1 
HETATM 3040 C  C5  . EPE H 3 .   ? 38.28196  4.59385   -40.26969 1.000 77.02281  ? 401 EPE B C5  1 
HETATM 3041 C  C6  . EPE H 3 .   ? 37.17142  5.49443   -40.78994 1.000 76.11775  ? 401 EPE B C6  1 
HETATM 3042 C  C9  . EPE H 3 .   ? 34.85251  5.97986   -40.59408 1.000 74.94471  ? 401 EPE B C9  1 
HETATM 3043 C  C10 . EPE H 3 .   ? 35.03317  7.23505   -39.76175 1.000 72.06570  ? 401 EPE B C10 1 
HETATM 3044 S  S   . EPE H 3 .   ? 33.61854  8.33446   -39.95138 1.000 105.16617 ? 401 EPE B S   1 
HETATM 3045 O  O1S . EPE H 3 .   ? 33.93523  9.46709   -40.82830 1.000 87.97612  ? 401 EPE B O1S 1 
HETATM 3046 O  O2S . EPE H 3 .   ? 32.53306  7.52779   -40.50612 1.000 84.07367  ? 401 EPE B O2S 1 
HETATM 3047 O  O3S . EPE H 3 .   ? 33.24468  8.83424   -38.62978 1.000 90.21491  ? 401 EPE B O3S 1 
HETATM 3048 C  C1  . YM0 I 2 .   ? 37.86601  21.43905  -6.48889  1.000 52.43970  ? 402 YM0 B C1  1 
HETATM 3049 C  C2  . YM0 I 2 .   ? 37.91852  22.65570  -7.21657  1.000 49.01971  ? 402 YM0 B C2  1 
HETATM 3050 C  C3  . YM0 I 2 .   ? 36.71676  21.68772  -8.91787  1.000 47.59080  ? 402 YM0 B C3  1 
HETATM 3051 C  C4  . YM0 I 2 .   ? 36.67189  20.50188  -8.21410  1.000 49.54785  ? 402 YM0 B C4  1 
HETATM 3052 C  C5  . YM0 I 2 .   ? 38.55549  23.85004  -6.69150  1.000 58.16674  ? 402 YM0 B C5  1 
HETATM 3053 C  C6  . YM0 I 2 .   ? 36.11971  21.82700  -10.22817 1.000 55.09229  ? 402 YM0 B C6  1 
HETATM 3054 N  N1  . YM0 I 2 .   ? 37.34122  22.77169  -8.42155  1.000 50.87019  ? 402 YM0 B N1  1 
HETATM 3055 N  N2  . YM0 I 2 .   ? 37.23096  20.37621  -7.00757  1.000 46.35424  ? 402 YM0 B N2  1 
HETATM 3056 N  N3  . YM0 I 2 .   ? 38.42956  21.30609  -5.28023  1.000 50.41218  ? 402 YM0 B N3  1 
HETATM 3057 N  N4  . YM0 I 2 .   ? 39.13821  24.76092  -6.30796  1.000 58.31244  ? 402 YM0 B N4  1 
HETATM 3058 N  N5  . YM0 I 2 .   ? 35.66551  21.92786  -11.27726 1.000 60.99452  ? 402 YM0 B N5  1 
HETATM 3059 C  C9  . EPE J 3 .   ? 17.55901  18.43600  -8.68622  1.000 71.91226  ? 403 EPE B C9  1 
HETATM 3060 C  C10 . EPE J 3 .   ? 17.35604  19.66393  -9.57147  1.000 89.52277  ? 403 EPE B C10 1 
HETATM 3061 S  S   . EPE J 3 .   ? 17.42554  19.30636  -11.35060 1.000 123.38069 ? 403 EPE B S   1 
HETATM 3062 O  O1S . EPE J 3 .   ? 16.09320  18.99265  -11.87419 1.000 90.93403  ? 403 EPE B O1S 1 
HETATM 3063 O  O2S . EPE J 3 .   ? 17.97198  20.48202  -12.04524 1.000 74.93394  ? 403 EPE B O2S 1 
HETATM 3064 O  O3S . EPE J 3 .   ? 18.27169  18.13095  -11.56436 1.000 92.38841  ? 403 EPE B O3S 1 
HETATM 3065 ZN ZN  . ZN  K 5 .   ? 33.29819  0.80616   -32.69668 1.000 43.85156  ? 404 ZN  B ZN  1 
HETATM 3066 O  O   . HOH L 6 .   ? 2.74379   20.27788  -40.23333 1.000 57.12851  ? 501 HOH A O   1 
HETATM 3067 O  O   . HOH L 6 .   ? 5.23813   34.15218  -32.82720 1.000 61.57181  ? 502 HOH A O   1 
HETATM 3068 O  O   . HOH L 6 .   ? -4.19959  16.63425  1.20473   1.000 42.86205  ? 503 HOH A O   1 
HETATM 3069 O  O   . HOH L 6 .   ? -5.02032  20.52642  -36.53359 1.000 59.88915  ? 504 HOH A O   1 
HETATM 3070 O  O   . HOH L 6 .   ? -11.73936 14.06740  -24.52279 1.000 45.69711  ? 505 HOH A O   1 
HETATM 3071 O  O   . HOH L 6 .   ? -5.10208  17.23493  -32.02896 1.000 47.50196  ? 506 HOH A O   1 
HETATM 3072 O  O   . HOH L 6 .   ? -13.03847 16.34340  -36.20518 1.000 69.46826  ? 507 HOH A O   1 
HETATM 3073 O  O   . HOH L 6 .   ? -7.37933  19.50720  -11.45664 1.000 51.09970  ? 508 HOH A O   1 
HETATM 3074 O  O   . HOH L 6 .   ? -6.55288  5.40126   -19.16868 1.000 48.98675  ? 509 HOH A O   1 
HETATM 3075 O  O   . HOH L 6 .   ? 8.71602   13.07014  -17.02159 1.000 45.95192  ? 510 HOH A O   1 
HETATM 3076 O  O   . HOH L 6 .   ? -5.53723  12.42045  -14.59987 1.000 41.45817  ? 511 HOH A O   1 
HETATM 3077 O  O   . HOH L 6 .   ? 4.29147   24.13047  -4.71556  1.000 50.46301  ? 512 HOH A O   1 
HETATM 3078 O  O   . HOH L 6 .   ? -2.06393  4.76342   -25.43802 1.000 48.42217  ? 513 HOH A O   1 
HETATM 3079 O  O   . HOH L 6 .   ? -7.38346  9.19828   -27.84932 1.000 42.98771  ? 514 HOH A O   1 
HETATM 3080 O  O   . HOH L 6 .   ? 4.29695   8.99055   -22.77395 1.000 39.05652  ? 515 HOH A O   1 
HETATM 3081 O  O   . HOH L 6 .   ? -10.47309 20.97497  -15.52649 1.000 53.01605  ? 516 HOH A O   1 
HETATM 3082 O  O   . HOH L 6 .   ? 6.21724   18.57082  -28.05038 1.000 40.46626  ? 517 HOH A O   1 
HETATM 3083 O  O   . HOH L 6 .   ? 3.53689   14.44244  -4.42847  1.000 44.00155  ? 518 HOH A O   1 
HETATM 3084 O  O   . HOH L 6 .   ? 1.73577   20.01198  -15.25236 1.000 33.69710  ? 519 HOH A O   1 
HETATM 3085 O  O   . HOH L 6 .   ? 0.27452   12.27331  -8.20202  1.000 55.55120  ? 520 HOH A O   1 
HETATM 3086 O  O   . HOH L 6 .   ? -6.92149  31.69836  -16.01832 1.000 41.74832  ? 521 HOH A O   1 
HETATM 3087 O  O   . HOH L 6 .   ? -5.80099  31.23837  -8.26348  1.000 36.42603  ? 522 HOH A O   1 
HETATM 3088 O  O   . HOH L 6 .   ? -8.35133  12.85249  -21.89176 1.000 36.07778  ? 523 HOH A O   1 
HETATM 3089 O  O   . HOH L 6 .   ? -2.68268  10.86806  -22.64175 1.000 37.06711  ? 524 HOH A O   1 
HETATM 3090 O  O   . HOH L 6 .   ? -0.628    -0.740    -29.139   1.000 37.34713  ? 525 HOH A O   1 
HETATM 3091 O  O   . HOH L 6 .   ? -6.09213  11.84573  -21.26777 1.000 38.36644  ? 526 HOH A O   1 
HETATM 3092 O  O   . HOH L 6 .   ? 8.34296   21.91321  -14.45003 1.000 41.18711  ? 527 HOH A O   1 
HETATM 3093 O  O   . HOH L 6 .   ? -7.69994  12.85618  -13.13679 1.000 45.50431  ? 528 HOH A O   1 
HETATM 3094 O  O   . HOH L 6 .   ? -2.757    -1.149    -25.421   1.000 44.29853  ? 529 HOH A O   1 
HETATM 3095 O  O   . HOH L 6 .   ? -4.08602  13.89615  -20.85799 1.000 34.59830  ? 530 HOH A O   1 
HETATM 3096 O  O   . HOH L 6 .   ? 3.60951   33.86430  -30.63801 1.000 50.36514  ? 531 HOH A O   1 
HETATM 3097 O  O   . HOH L 6 .   ? 10.59507  15.79485  -16.09995 1.000 57.40878  ? 532 HOH A O   1 
HETATM 3098 O  O   . HOH L 6 .   ? 8.35951   30.93593  -25.90080 1.000 55.66345  ? 533 HOH A O   1 
HETATM 3099 O  O   . HOH L 6 .   ? -5.58854  20.11341  -15.55836 1.000 31.58670  ? 534 HOH A O   1 
HETATM 3100 O  O   . HOH L 6 .   ? -2.41773  18.60001  -6.25631  1.000 41.56008  ? 535 HOH A O   1 
HETATM 3101 O  O   . HOH L 6 .   ? 9.38742   35.98656  -19.32373 1.000 63.07312  ? 536 HOH A O   1 
HETATM 3102 O  O   . HOH L 6 .   ? -2.23981  35.12095  -33.76024 1.000 43.03040  ? 537 HOH A O   1 
HETATM 3103 O  O   . HOH L 6 .   ? -3.45040  15.27168  -3.33394  1.000 45.04027  ? 538 HOH A O   1 
HETATM 3104 O  O   . HOH L 6 .   ? 11.27958  25.84854  -15.05872 1.000 63.49265  ? 539 HOH A O   1 
HETATM 3105 O  O   . HOH L 6 .   ? -0.05853  17.10062  -3.52300  1.000 40.91258  ? 540 HOH A O   1 
HETATM 3106 O  O   . HOH L 6 .   ? -0.02344  13.16425  -19.17517 1.000 30.91739  ? 541 HOH A O   1 
HETATM 3107 O  O   . HOH L 6 .   ? 6.73336   30.71092  -24.02086 1.000 49.98587  ? 542 HOH A O   1 
HETATM 3108 O  O   . HOH L 6 .   ? -9.02567  30.11889  -6.07041  1.000 48.87566  ? 543 HOH A O   1 
HETATM 3109 O  O   . HOH L 6 .   ? 8.39498   24.87748  -13.27616 1.000 46.47752  ? 544 HOH A O   1 
HETATM 3110 O  O   . HOH L 6 .   ? -6.75561  4.38612   -14.68284 1.000 58.02196  ? 545 HOH A O   1 
HETATM 3111 O  O   . HOH L 6 .   ? -13.26912 19.57313  -13.78620 1.000 54.65873  ? 546 HOH A O   1 
HETATM 3112 O  O   . HOH L 6 .   ? 10.32330  12.85749  -22.99752 1.000 62.58680  ? 547 HOH A O   1 
HETATM 3113 O  O   . HOH L 6 .   ? -3.60825  16.01176  -5.69239  1.000 39.69470  ? 548 HOH A O   1 
HETATM 3114 O  O   . HOH L 6 .   ? 9.55689   22.01259  -16.79048 1.000 40.62533  ? 549 HOH A O   1 
HETATM 3115 O  O   . HOH L 6 .   ? 11.80352  20.27022  -9.42942  1.000 53.22771  ? 550 HOH A O   1 
HETATM 3116 O  O   . HOH L 6 .   ? -1.45653  13.23887  -21.33441 1.000 32.74582  ? 551 HOH A O   1 
HETATM 3117 O  O   . HOH L 6 .   ? 6.30966   25.04737  -11.49063 1.000 43.75437  ? 552 HOH A O   1 
HETATM 3118 O  O   . HOH L 6 .   ? 1.15302   36.38619  -36.02831 1.000 55.27756  ? 553 HOH A O   1 
HETATM 3119 O  O   . HOH L 6 .   ? 4.66207   9.31262   -11.57266 1.000 38.91126  ? 554 HOH A O   1 
HETATM 3120 O  O   . HOH L 6 .   ? -9.99387  28.44517  -26.78046 1.000 61.29421  ? 555 HOH A O   1 
HETATM 3121 O  O   . HOH L 6 .   ? 0.02139   12.80820  -5.76607  1.000 53.69675  ? 556 HOH A O   1 
HETATM 3122 O  O   . HOH L 6 .   ? -12.70212 6.93518   -23.46718 1.000 51.73085  ? 557 HOH A O   1 
HETATM 3123 O  O   . HOH L 6 .   ? -1.82333  6.55548   -11.41865 1.000 59.19799  ? 558 HOH A O   1 
HETATM 3124 O  O   . HOH L 6 .   ? -2.09053  13.27779  -9.12402  1.000 41.28166  ? 559 HOH A O   1 
HETATM 3125 O  O   . HOH L 6 .   ? -10.24731 18.73167  0.52498   1.000 61.42405  ? 560 HOH A O   1 
HETATM 3126 O  O   . HOH L 6 .   ? -18.502   10.435    -12.057   1.000 57.68583  ? 561 HOH A O   1 
HETATM 3127 O  O   . HOH L 6 .   ? 3.86279   35.08474  -11.55294 1.000 48.54518  ? 562 HOH A O   1 
HETATM 3128 O  O   . HOH L 6 .   ? -11.99833 33.92247  -11.05703 1.000 45.80884  ? 563 HOH A O   1 
HETATM 3129 O  O   . HOH L 6 .   ? 13.30175  21.13462  -11.91044 1.000 65.51358  ? 564 HOH A O   1 
HETATM 3130 O  O   . HOH L 6 .   ? -5.68691  15.38629  -7.41369  1.000 48.87230  ? 565 HOH A O   1 
HETATM 3131 O  O   . HOH L 6 .   ? 7.78589   9.20735   -34.56221 1.000 58.16836  ? 566 HOH A O   1 
HETATM 3132 O  O   . HOH L 6 .   ? -3.60286  3.82422   -11.64038 1.000 64.42559  ? 567 HOH A O   1 
HETATM 3133 O  O   . HOH L 6 .   ? 5.52745   8.54016   -36.57138 1.000 52.91634  ? 568 HOH A O   1 
HETATM 3134 O  O   . HOH L 6 .   ? 1.01909   14.43101  -3.55884  1.000 43.79713  ? 569 HOH A O   1 
HETATM 3135 O  O   . HOH L 6 .   ? 10.16693  7.74020   -32.73542 1.000 62.69244  ? 570 HOH A O   1 
HETATM 3136 O  O   . HOH L 6 .   ? -10.57127 14.07323  -9.97522  1.000 56.58521  ? 571 HOH A O   1 
HETATM 3137 O  O   . HOH L 6 .   ? -7.50857  15.31676  -12.05567 1.000 49.02717  ? 572 HOH A O   1 
HETATM 3138 O  O   . HOH L 6 .   ? 12.30954  23.59513  -16.48882 1.000 68.95564  ? 573 HOH A O   1 
HETATM 3139 O  O   . HOH L 6 .   ? 5.56388   20.76962  -3.18257  1.000 49.30531  ? 574 HOH A O   1 
HETATM 3140 O  O   . HOH L 6 .   ? -8.35229  18.84947  -16.08331 1.000 48.82359  ? 575 HOH A O   1 
HETATM 3141 O  O   . HOH L 6 .   ? 4.10064   19.20506  -4.11328  1.000 40.63914  ? 576 HOH A O   1 
HETATM 3142 O  O   . HOH L 6 .   ? -8.15832  17.64721  -13.10998 1.000 55.75609  ? 577 HOH A O   1 
HETATM 3143 O  O   . HOH L 6 .   ? 1.54740   6.20147   -36.92460 1.000 61.33992  ? 578 HOH A O   1 
HETATM 3144 O  O   . HOH L 6 .   ? -4.12743  12.02411  -7.26441  1.000 68.66832  ? 579 HOH A O   1 
HETATM 3145 O  O   . HOH L 6 .   ? -11.10637 15.18742  -7.43711  1.000 79.05969  ? 580 HOH A O   1 
HETATM 3146 O  O   . HOH M 6 .   ? 25.74320  12.07466  -11.19807 1.000 46.76336  ? 501 HOH B O   1 
HETATM 3147 O  O   . HOH M 6 .   ? 36.60696  6.44507   -4.42927  1.000 44.41872  ? 502 HOH B O   1 
HETATM 3148 O  O   . HOH M 6 .   ? 41.47312  5.18395   -17.26958 1.000 45.99403  ? 503 HOH B O   1 
HETATM 3149 O  O   . HOH M 6 .   ? 17.82650  13.48905  -20.79620 1.000 56.99353  ? 504 HOH B O   1 
HETATM 3150 O  O   . HOH M 6 .   ? 26.22031  23.90967  -15.58840 1.000 47.07989  ? 505 HOH B O   1 
HETATM 3151 O  O   . HOH M 6 .   ? 38.80199  10.69871  -28.25966 1.000 40.31084  ? 506 HOH B O   1 
HETATM 3152 O  O   . HOH M 6 .   ? 34.647    11.237    -2.857    1.000 36.68736  ? 507 HOH B O   1 
HETATM 3153 O  O   . HOH M 6 .   ? 25.28830  1.51521   -27.71644 1.000 41.90821  ? 508 HOH B O   1 
HETATM 3154 O  O   . HOH M 6 .   ? 20.87121  6.47048   -24.22296 1.000 42.25729  ? 509 HOH B O   1 
HETATM 3155 O  O   . HOH M 6 .   ? 36.06131  26.26897  -30.76965 1.000 53.06792  ? 510 HOH B O   1 
HETATM 3156 O  O   . HOH M 6 .   ? 30.80341  10.75617  -6.12443  1.000 45.79932  ? 511 HOH B O   1 
HETATM 3157 O  O   . HOH M 6 .   ? 32.65487  9.17962   -3.52067  1.000 40.84996  ? 512 HOH B O   1 
HETATM 3158 O  O   . HOH M 6 .   ? 43.24752  7.86245   -16.56353 1.000 53.69632  ? 513 HOH B O   1 
HETATM 3159 O  O   . HOH M 6 .   ? 22.43071  12.89647  -15.30047 1.000 55.77984  ? 514 HOH B O   1 
HETATM 3160 O  O   . HOH M 6 .   ? 30.290    -8.750    -25.427   1.000 43.34755  ? 515 HOH B O   1 
HETATM 3161 O  O   . HOH M 6 .   ? 30.74853  -3.09433  -25.56553 1.000 48.55380  ? 516 HOH B O   1 
HETATM 3162 O  O   . HOH M 6 .   ? 30.89874  17.51579  -1.97383  1.000 38.95998  ? 517 HOH B O   1 
HETATM 3163 O  O   . HOH M 6 .   ? 30.91129  10.31745  2.11895   1.000 45.79551  ? 518 HOH B O   1 
HETATM 3164 O  O   . HOH M 6 .   ? 27.42713  9.56017   -32.05893 1.000 47.97303  ? 519 HOH B O   1 
HETATM 3165 O  O   . HOH M 6 .   ? 37.08988  1.42813   -22.93242 1.000 41.47825  ? 520 HOH B O   1 
HETATM 3166 O  O   . HOH M 6 .   ? 34.57794  12.00420  -15.20987 1.000 34.92867  ? 521 HOH B O   1 
HETATM 3167 O  O   . HOH M 6 .   ? 34.623    16.467    2.883     1.000 33.10201  ? 522 HOH B O   1 
HETATM 3168 O  O   . HOH M 6 .   ? 30.33087  27.46601  -33.68914 1.000 42.86636  ? 523 HOH B O   1 
HETATM 3169 O  O   . HOH M 6 .   ? 20.54600  9.61075   -30.54267 1.000 45.28181  ? 524 HOH B O   1 
HETATM 3170 O  O   . HOH M 6 .   ? 27.40488  23.49127  -7.96759  1.000 36.53828  ? 525 HOH B O   1 
HETATM 3171 O  O   . HOH M 6 .   ? 24.24083  5.13323   -21.69978 1.000 30.63992  ? 526 HOH B O   1 
HETATM 3172 O  O   . HOH M 6 .   ? 30.09783  3.19238   -22.61270 1.000 37.82853  ? 527 HOH B O   1 
HETATM 3173 O  O   . HOH M 6 .   ? 32.466    -8.619    -29.287   1.000 43.68095  ? 528 HOH B O   1 
HETATM 3174 O  O   . HOH M 6 .   ? 27.24927  4.50095   -14.70825 1.000 38.66315  ? 529 HOH B O   1 
HETATM 3175 O  O   . HOH M 6 .   ? 31.20644  -2.78162  -19.24802 1.000 53.48370  ? 530 HOH B O   1 
HETATM 3176 O  O   . HOH M 6 .   ? 28.70815  8.70709   1.49870   1.000 42.26640  ? 531 HOH B O   1 
HETATM 3177 O  O   . HOH M 6 .   ? 33.12929  3.58447   -8.68611  1.000 59.11213  ? 532 HOH B O   1 
HETATM 3178 O  O   . HOH M 6 .   ? 24.98253  5.13538   -12.92212 1.000 47.14198  ? 533 HOH B O   1 
HETATM 3179 O  O   . HOH M 6 .   ? 22.40379  5.31249   -14.52911 1.000 50.19620  ? 534 HOH B O   1 
HETATM 3180 O  O   . HOH M 6 .   ? 24.86804  22.49293  -5.58622  1.000 44.27374  ? 535 HOH B O   1 
HETATM 3181 O  O   . HOH M 6 .   ? 32.94939  4.76639   -6.14256  1.000 56.10554  ? 536 HOH B O   1 
HETATM 3182 O  O   . HOH M 6 .   ? 27.32111  12.23583  -15.44515 1.000 30.05773  ? 537 HOH B O   1 
HETATM 3183 O  O   . HOH M 6 .   ? 26.60015  4.11350   -21.02015 1.000 32.17217  ? 538 HOH B O   1 
HETATM 3184 O  O   . HOH M 6 .   ? 42.37530  13.98100  -17.07730 1.000 46.69427  ? 539 HOH B O   1 
HETATM 3185 O  O   . HOH M 6 .   ? 19.36587  22.34763  -19.72450 1.000 57.87052  ? 540 HOH B O   1 
HETATM 3186 O  O   . HOH M 6 .   ? 24.20475  23.42025  -21.21382 1.000 60.00046  ? 541 HOH B O   1 
HETATM 3187 O  O   . HOH M 6 .   ? 30.88103  -1.13344  -11.63444 1.000 49.04785  ? 542 HOH B O   1 
HETATM 3188 O  O   . HOH M 6 .   ? 40.20818  16.93359  -38.68446 1.000 63.54989  ? 543 HOH B O   1 
HETATM 3189 O  O   . HOH M 6 .   ? 29.17194  8.11673   -5.80787  1.000 44.48962  ? 544 HOH B O   1 
HETATM 3190 O  O   . HOH M 6 .   ? 21.75696  26.39235  -10.46495 1.000 51.21723  ? 545 HOH B O   1 
HETATM 3191 O  O   . HOH M 6 .   ? 28.62040  6.27081   -20.84714 1.000 32.42469  ? 546 HOH B O   1 
HETATM 3192 O  O   . HOH M 6 .   ? 41.83541  13.96756  -14.61655 1.000 48.08007  ? 547 HOH B O   1 
HETATM 3193 O  O   . HOH M 6 .   ? 23.70164  -0.69517  -32.80767 1.000 54.90451  ? 548 HOH B O   1 
HETATM 3194 O  O   . HOH M 6 .   ? 23.87150  19.10935  -33.14530 1.000 53.18841  ? 549 HOH B O   1 
HETATM 3195 O  O   . HOH M 6 .   ? 20.52098  -0.93442  -23.67131 1.000 44.41463  ? 550 HOH B O   1 
HETATM 3196 O  O   . HOH M 6 .   ? 32.67095  5.36791   -19.07664 1.000 33.98741  ? 551 HOH B O   1 
HETATM 3197 O  O   . HOH M 6 .   ? 29.61485  2.39507   -30.37625 1.000 54.31814  ? 552 HOH B O   1 
HETATM 3198 O  O   . HOH M 6 .   ? 31.20577  5.43248   -21.24728 1.000 36.45530  ? 553 HOH B O   1 
HETATM 3199 O  O   . HOH M 6 .   ? 31.03581  5.37266   -9.10763  1.000 46.05965  ? 554 HOH B O   1 
HETATM 3200 O  O   . HOH M 6 .   ? 18.32836  15.27366  -26.23436 1.000 54.76896  ? 555 HOH B O   1 
HETATM 3201 O  O   . HOH M 6 .   ? 30.92485  -0.11747  -38.54662 1.000 55.27807  ? 556 HOH B O   1 
HETATM 3202 O  O   . HOH M 6 .   ? 25.75473  6.44939   -1.59998  1.000 55.00950  ? 557 HOH B O   1 
HETATM 3203 O  O   . HOH M 6 .   ? 25.79415  26.64102  -17.31298 1.000 53.93576  ? 558 HOH B O   1 
HETATM 3204 O  O   . HOH M 6 .   ? 35.88559  29.06705  -2.25367  1.000 61.93132  ? 559 HOH B O   1 
HETATM 3205 O  O   . HOH M 6 .   ? 22.87161  20.68508  -26.49726 1.000 56.53702  ? 560 HOH B O   1 
HETATM 3206 O  O   . HOH M 6 .   ? 43.31622  5.34012   -23.38386 1.000 49.87287  ? 561 HOH B O   1 
HETATM 3207 O  O   . HOH M 6 .   ? 36.45922  -7.65829  -33.62979 1.000 51.65993  ? 562 HOH B O   1 
HETATM 3208 O  O   . HOH M 6 .   ? 36.94427  8.70768   -8.42885  1.000 44.47506  ? 563 HOH B O   1 
HETATM 3209 O  O   . HOH M 6 .   ? 13.72419  13.37310  -30.43396 1.000 69.01648  ? 564 HOH B O   1 
HETATM 3210 O  O   . HOH M 6 .   ? 45.28529  12.11857  -9.98487  1.000 57.66130  ? 565 HOH B O   1 
HETATM 3211 O  O   . HOH M 6 .   ? 37.41319  1.17946   -11.59236 1.000 44.38069  ? 566 HOH B O   1 
HETATM 3212 O  O   . HOH M 6 .   ? 39.34651  17.15430  -11.72236 1.000 50.79423  ? 567 HOH B O   1 
HETATM 3213 O  O   . HOH M 6 .   ? 34.43232  23.65763  0.36835   1.000 47.25837  ? 568 HOH B O   1 
HETATM 3214 O  O   . HOH M 6 .   ? 21.22495  26.66401  -13.38686 1.000 50.23145  ? 569 HOH B O   1 
HETATM 3215 O  O   . HOH M 6 .   ? 41.53579  16.83658  -12.99991 1.000 49.41529  ? 570 HOH B O   1 
HETATM 3216 O  O   . HOH M 6 .   ? 35.84538  -1.41404  -13.11888 1.000 58.15695  ? 571 HOH B O   1 
HETATM 3217 O  O   . HOH M 6 .   ? 44.61387  5.61581   -25.68531 1.000 67.58524  ? 572 HOH B O   1 
HETATM 3218 O  O   . HOH M 6 .   ? 36.968    11.275    -4.021    1.000 39.68419  ? 573 HOH B O   1 
HETATM 3219 O  O   . HOH M 6 .   ? 20.26434  6.98164   -14.34914 1.000 61.96875  ? 574 HOH B O   1 
HETATM 3220 O  O   . HOH M 6 .   ? 28.79973  4.48681   -7.39537  1.000 63.41894  ? 575 HOH B O   1 
HETATM 3221 O  O   . HOH M 6 .   ? 24.51868  10.19099  -13.06751 1.000 49.32562  ? 576 HOH B O   1 
HETATM 3222 O  O   . HOH M 6 .   ? 24.50553  11.11038  -15.74527 1.000 51.64692  ? 577 HOH B O   1 
# 
