data_8R39
# 
_entry.id   8R39 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8R39         pdb_00008r39 10.2210/pdb8r39/pdb 
WWPDB D_1292134553 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-11-20 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8R39 
_pdbx_database_status.recvd_initial_deposition_date   2023-11-08 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              a.guskov@rug.nl 
_pdbx_contact_author.name_first         Albert 
_pdbx_contact_author.name_last          Guskov 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-2340-2216 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Whittaker, J.J.' 1 0000-0001-8966-111X 
'Guskov, A.'      2 0000-0003-2340-2216 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Full-length LpMIP mutant Y16F' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Whittaker, J.J.' 1 0000-0001-8966-111X 
primary 'Guskov, A.'      2 0000-0003-2340-2216 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Peptidyl-prolyl cis-trans isomerase'  22393.562 1  ? Y16F ? ? 
2 non-polymer syn GLYCEROL                               92.094    3  ? ?    ? ? 
3 non-polymer syn '2-(N-MORPHOLINO)-ETHANESULFONIC ACID' 195.237   1  ? ?    ? ? 
4 non-polymer syn 'DI(HYDROXYETHYL)ETHER'                106.120   2  ? ?    ? ? 
5 non-polymer nat 'SODIUM ION'                           22.990    1  ? ?    ? ? 
6 water       nat water                                  18.015    64 ? ?    ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;SLATDKDKLSFSIGADLGKNFKNQGIDVNPEAMAKGMQDAMSGAQLALTEQQMKDVLNKFQKDLMAKRTAEFNKKADENK
VKGEAFLTENKNKPGVVVLPSGLQYKVINSGNGVKPGKSDTVTVEYTGRLIDGTVFDSTEKTGKPATFQVSQVIPGWTEA
LQLMPAGSTWEIYVPSGLAYGPRSVGGPIGPNETLIFKIHLISVKKSS
;
_entity_poly.pdbx_seq_one_letter_code_can   
;SLATDKDKLSFSIGADLGKNFKNQGIDVNPEAMAKGMQDAMSGAQLALTEQQMKDVLNKFQKDLMAKRTAEFNKKADENK
VKGEAFLTENKNKPGVVVLPSGLQYKVINSGNGVKPGKSDTVTVEYTGRLIDGTVFDSTEKTGKPATFQVSQVIPGWTEA
LQLMPAGSTWEIYVPSGLAYGPRSVGGPIGPNETLIFKIHLISVKKSS
;
_entity_poly.pdbx_strand_id                 C 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 GLYCEROL                               GOL 
3 '2-(N-MORPHOLINO)-ETHANESULFONIC ACID' MES 
4 'DI(HYDROXYETHYL)ETHER'                PEG 
5 'SODIUM ION'                           NA  
6 water                                  HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   LEU n 
1 3   ALA n 
1 4   THR n 
1 5   ASP n 
1 6   LYS n 
1 7   ASP n 
1 8   LYS n 
1 9   LEU n 
1 10  SER n 
1 11  PHE n 
1 12  SER n 
1 13  ILE n 
1 14  GLY n 
1 15  ALA n 
1 16  ASP n 
1 17  LEU n 
1 18  GLY n 
1 19  LYS n 
1 20  ASN n 
1 21  PHE n 
1 22  LYS n 
1 23  ASN n 
1 24  GLN n 
1 25  GLY n 
1 26  ILE n 
1 27  ASP n 
1 28  VAL n 
1 29  ASN n 
1 30  PRO n 
1 31  GLU n 
1 32  ALA n 
1 33  MET n 
1 34  ALA n 
1 35  LYS n 
1 36  GLY n 
1 37  MET n 
1 38  GLN n 
1 39  ASP n 
1 40  ALA n 
1 41  MET n 
1 42  SER n 
1 43  GLY n 
1 44  ALA n 
1 45  GLN n 
1 46  LEU n 
1 47  ALA n 
1 48  LEU n 
1 49  THR n 
1 50  GLU n 
1 51  GLN n 
1 52  GLN n 
1 53  MET n 
1 54  LYS n 
1 55  ASP n 
1 56  VAL n 
1 57  LEU n 
1 58  ASN n 
1 59  LYS n 
1 60  PHE n 
1 61  GLN n 
1 62  LYS n 
1 63  ASP n 
1 64  LEU n 
1 65  MET n 
1 66  ALA n 
1 67  LYS n 
1 68  ARG n 
1 69  THR n 
1 70  ALA n 
1 71  GLU n 
1 72  PHE n 
1 73  ASN n 
1 74  LYS n 
1 75  LYS n 
1 76  ALA n 
1 77  ASP n 
1 78  GLU n 
1 79  ASN n 
1 80  LYS n 
1 81  VAL n 
1 82  LYS n 
1 83  GLY n 
1 84  GLU n 
1 85  ALA n 
1 86  PHE n 
1 87  LEU n 
1 88  THR n 
1 89  GLU n 
1 90  ASN n 
1 91  LYS n 
1 92  ASN n 
1 93  LYS n 
1 94  PRO n 
1 95  GLY n 
1 96  VAL n 
1 97  VAL n 
1 98  VAL n 
1 99  LEU n 
1 100 PRO n 
1 101 SER n 
1 102 GLY n 
1 103 LEU n 
1 104 GLN n 
1 105 TYR n 
1 106 LYS n 
1 107 VAL n 
1 108 ILE n 
1 109 ASN n 
1 110 SER n 
1 111 GLY n 
1 112 ASN n 
1 113 GLY n 
1 114 VAL n 
1 115 LYS n 
1 116 PRO n 
1 117 GLY n 
1 118 LYS n 
1 119 SER n 
1 120 ASP n 
1 121 THR n 
1 122 VAL n 
1 123 THR n 
1 124 VAL n 
1 125 GLU n 
1 126 TYR n 
1 127 THR n 
1 128 GLY n 
1 129 ARG n 
1 130 LEU n 
1 131 ILE n 
1 132 ASP n 
1 133 GLY n 
1 134 THR n 
1 135 VAL n 
1 136 PHE n 
1 137 ASP n 
1 138 SER n 
1 139 THR n 
1 140 GLU n 
1 141 LYS n 
1 142 THR n 
1 143 GLY n 
1 144 LYS n 
1 145 PRO n 
1 146 ALA n 
1 147 THR n 
1 148 PHE n 
1 149 GLN n 
1 150 VAL n 
1 151 SER n 
1 152 GLN n 
1 153 VAL n 
1 154 ILE n 
1 155 PRO n 
1 156 GLY n 
1 157 TRP n 
1 158 THR n 
1 159 GLU n 
1 160 ALA n 
1 161 LEU n 
1 162 GLN n 
1 163 LEU n 
1 164 MET n 
1 165 PRO n 
1 166 ALA n 
1 167 GLY n 
1 168 SER n 
1 169 THR n 
1 170 TRP n 
1 171 GLU n 
1 172 ILE n 
1 173 TYR n 
1 174 VAL n 
1 175 PRO n 
1 176 SER n 
1 177 GLY n 
1 178 LEU n 
1 179 ALA n 
1 180 TYR n 
1 181 GLY n 
1 182 PRO n 
1 183 ARG n 
1 184 SER n 
1 185 VAL n 
1 186 GLY n 
1 187 GLY n 
1 188 PRO n 
1 189 ILE n 
1 190 GLY n 
1 191 PRO n 
1 192 ASN n 
1 193 GLU n 
1 194 THR n 
1 195 LEU n 
1 196 ILE n 
1 197 PHE n 
1 198 LYS n 
1 199 ILE n 
1 200 HIS n 
1 201 LEU n 
1 202 ILE n 
1 203 SER n 
1 204 VAL n 
1 205 LYS n 
1 206 LYS n 
1 207 SER n 
1 208 SER n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   208 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 C3927_03235 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Legionella pneumophila' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     446 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                ?                               'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                               ?                               'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                             ?                               'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                        ?                               'C4 H7 N O4'     133.103 
GLN 'L-peptide linking' y GLUTAMINE                              ?                               'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                        ?                               'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                                ?                               'C2 H5 N O2'     75.067  
GOL non-polymer         . GLYCEROL                               'GLYCERIN; PROPANE-1,2,3-TRIOL' 'C3 H8 O3'       92.094  
HIS 'L-peptide linking' y HISTIDINE                              ?                               'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                                  ?                               'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE                             ?                               'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                                ?                               'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                                 ?                               'C6 H15 N2 O2 1' 147.195 
MES non-polymer         . '2-(N-MORPHOLINO)-ETHANESULFONIC ACID' ?                               'C6 H13 N O4 S'  195.237 
MET 'L-peptide linking' y METHIONINE                             ?                               'C5 H11 N O2 S'  149.211 
NA  non-polymer         . 'SODIUM ION'                           ?                               'Na 1'           22.990  
PEG non-polymer         . 'DI(HYDROXYETHYL)ETHER'                ?                               'C4 H10 O3'      106.120 
PHE 'L-peptide linking' y PHENYLALANINE                          ?                               'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE                                ?                               'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                                 ?                               'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                              ?                               'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                             ?                               'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                               ?                               'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                                 ?                               'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   6   6   SER SER C . n 
A 1 2   LEU 2   7   7   LEU LEU C . n 
A 1 3   ALA 3   8   8   ALA ALA C . n 
A 1 4   THR 4   9   9   THR THR C . n 
A 1 5   ASP 5   10  10  ASP ASP C . n 
A 1 6   LYS 6   11  11  LYS LYS C . n 
A 1 7   ASP 7   12  12  ASP ASP C . n 
A 1 8   LYS 8   13  13  LYS LYS C . n 
A 1 9   LEU 9   14  14  LEU LEU C . n 
A 1 10  SER 10  15  15  SER SER C . n 
A 1 11  PHE 11  16  16  PHE PHE C . n 
A 1 12  SER 12  17  17  SER SER C . n 
A 1 13  ILE 13  18  18  ILE ILE C . n 
A 1 14  GLY 14  19  19  GLY GLY C . n 
A 1 15  ALA 15  20  20  ALA ALA C . n 
A 1 16  ASP 16  21  21  ASP ASP C . n 
A 1 17  LEU 17  22  22  LEU LEU C . n 
A 1 18  GLY 18  23  23  GLY GLY C . n 
A 1 19  LYS 19  24  24  LYS LYS C . n 
A 1 20  ASN 20  25  25  ASN ASN C . n 
A 1 21  PHE 21  26  26  PHE PHE C . n 
A 1 22  LYS 22  27  27  LYS LYS C . n 
A 1 23  ASN 23  28  28  ASN ASN C . n 
A 1 24  GLN 24  29  29  GLN GLN C . n 
A 1 25  GLY 25  30  30  GLY GLY C . n 
A 1 26  ILE 26  31  31  ILE ILE C . n 
A 1 27  ASP 27  32  32  ASP ASP C . n 
A 1 28  VAL 28  33  33  VAL VAL C . n 
A 1 29  ASN 29  34  34  ASN ASN C . n 
A 1 30  PRO 30  35  35  PRO PRO C . n 
A 1 31  GLU 31  36  36  GLU GLU C . n 
A 1 32  ALA 32  37  37  ALA ALA C . n 
A 1 33  MET 33  38  38  MET MET C . n 
A 1 34  ALA 34  39  39  ALA ALA C . n 
A 1 35  LYS 35  40  40  LYS LYS C . n 
A 1 36  GLY 36  41  41  GLY GLY C . n 
A 1 37  MET 37  42  42  MET MET C . n 
A 1 38  GLN 38  43  43  GLN GLN C . n 
A 1 39  ASP 39  44  44  ASP ASP C . n 
A 1 40  ALA 40  45  45  ALA ALA C . n 
A 1 41  MET 41  46  46  MET MET C . n 
A 1 42  SER 42  47  47  SER SER C . n 
A 1 43  GLY 43  48  48  GLY GLY C . n 
A 1 44  ALA 44  49  49  ALA ALA C . n 
A 1 45  GLN 45  50  50  GLN GLN C . n 
A 1 46  LEU 46  51  51  LEU LEU C . n 
A 1 47  ALA 47  52  52  ALA ALA C . n 
A 1 48  LEU 48  53  53  LEU LEU C . n 
A 1 49  THR 49  54  54  THR THR C . n 
A 1 50  GLU 50  55  55  GLU GLU C . n 
A 1 51  GLN 51  56  56  GLN GLN C . n 
A 1 52  GLN 52  57  57  GLN GLN C . n 
A 1 53  MET 53  58  58  MET MET C . n 
A 1 54  LYS 54  59  59  LYS LYS C . n 
A 1 55  ASP 55  60  60  ASP ASP C . n 
A 1 56  VAL 56  61  61  VAL VAL C . n 
A 1 57  LEU 57  62  62  LEU LEU C . n 
A 1 58  ASN 58  63  63  ASN ASN C . n 
A 1 59  LYS 59  64  64  LYS LYS C . n 
A 1 60  PHE 60  65  65  PHE PHE C . n 
A 1 61  GLN 61  66  66  GLN GLN C . n 
A 1 62  LYS 62  67  67  LYS LYS C . n 
A 1 63  ASP 63  68  68  ASP ASP C . n 
A 1 64  LEU 64  69  69  LEU LEU C . n 
A 1 65  MET 65  70  70  MET MET C . n 
A 1 66  ALA 66  71  71  ALA ALA C . n 
A 1 67  LYS 67  72  72  LYS LYS C . n 
A 1 68  ARG 68  73  73  ARG ARG C . n 
A 1 69  THR 69  74  74  THR THR C . n 
A 1 70  ALA 70  75  75  ALA ALA C . n 
A 1 71  GLU 71  76  76  GLU GLU C . n 
A 1 72  PHE 72  77  77  PHE PHE C . n 
A 1 73  ASN 73  78  78  ASN ASN C . n 
A 1 74  LYS 74  79  79  LYS LYS C . n 
A 1 75  LYS 75  80  80  LYS LYS C . n 
A 1 76  ALA 76  81  81  ALA ALA C . n 
A 1 77  ASP 77  82  82  ASP ASP C . n 
A 1 78  GLU 78  83  83  GLU GLU C . n 
A 1 79  ASN 79  84  84  ASN ASN C . n 
A 1 80  LYS 80  85  85  LYS LYS C . n 
A 1 81  VAL 81  86  86  VAL VAL C . n 
A 1 82  LYS 82  87  87  LYS LYS C . n 
A 1 83  GLY 83  88  88  GLY GLY C . n 
A 1 84  GLU 84  89  89  GLU GLU C . n 
A 1 85  ALA 85  90  90  ALA ALA C . n 
A 1 86  PHE 86  91  91  PHE PHE C . n 
A 1 87  LEU 87  92  92  LEU LEU C . n 
A 1 88  THR 88  93  93  THR THR C . n 
A 1 89  GLU 89  94  94  GLU GLU C . n 
A 1 90  ASN 90  95  95  ASN ASN C . n 
A 1 91  LYS 91  96  96  LYS LYS C . n 
A 1 92  ASN 92  97  97  ASN ASN C . n 
A 1 93  LYS 93  98  98  LYS LYS C . n 
A 1 94  PRO 94  99  99  PRO PRO C . n 
A 1 95  GLY 95  100 100 GLY GLY C . n 
A 1 96  VAL 96  101 101 VAL VAL C . n 
A 1 97  VAL 97  102 102 VAL VAL C . n 
A 1 98  VAL 98  103 103 VAL VAL C . n 
A 1 99  LEU 99  104 104 LEU LEU C . n 
A 1 100 PRO 100 105 105 PRO PRO C . n 
A 1 101 SER 101 106 106 SER SER C . n 
A 1 102 GLY 102 107 107 GLY GLY C . n 
A 1 103 LEU 103 108 108 LEU LEU C . n 
A 1 104 GLN 104 109 109 GLN GLN C . n 
A 1 105 TYR 105 110 110 TYR TYR C . n 
A 1 106 LYS 106 111 111 LYS LYS C . n 
A 1 107 VAL 107 112 112 VAL VAL C . n 
A 1 108 ILE 108 113 113 ILE ILE C . n 
A 1 109 ASN 109 114 114 ASN ASN C . n 
A 1 110 SER 110 115 115 SER SER C . n 
A 1 111 GLY 111 116 116 GLY GLY C . n 
A 1 112 ASN 112 117 117 ASN ASN C . n 
A 1 113 GLY 113 118 118 GLY GLY C . n 
A 1 114 VAL 114 119 119 VAL VAL C . n 
A 1 115 LYS 115 120 120 LYS LYS C . n 
A 1 116 PRO 116 121 121 PRO PRO C . n 
A 1 117 GLY 117 122 122 GLY GLY C . n 
A 1 118 LYS 118 123 123 LYS LYS C . n 
A 1 119 SER 119 124 124 SER SER C . n 
A 1 120 ASP 120 125 125 ASP ASP C . n 
A 1 121 THR 121 126 126 THR THR C . n 
A 1 122 VAL 122 127 127 VAL VAL C . n 
A 1 123 THR 123 128 128 THR THR C . n 
A 1 124 VAL 124 129 129 VAL VAL C . n 
A 1 125 GLU 125 130 130 GLU GLU C . n 
A 1 126 TYR 126 131 131 TYR TYR C . n 
A 1 127 THR 127 132 132 THR THR C . n 
A 1 128 GLY 128 133 133 GLY GLY C . n 
A 1 129 ARG 129 134 134 ARG ARG C . n 
A 1 130 LEU 130 135 135 LEU LEU C . n 
A 1 131 ILE 131 136 136 ILE ILE C . n 
A 1 132 ASP 132 137 137 ASP ASP C . n 
A 1 133 GLY 133 138 138 GLY GLY C . n 
A 1 134 THR 134 139 139 THR THR C . n 
A 1 135 VAL 135 140 140 VAL VAL C . n 
A 1 136 PHE 136 141 141 PHE PHE C . n 
A 1 137 ASP 137 142 142 ASP ASP C . n 
A 1 138 SER 138 143 143 SER SER C . n 
A 1 139 THR 139 144 144 THR THR C . n 
A 1 140 GLU 140 145 145 GLU GLU C . n 
A 1 141 LYS 141 146 146 LYS LYS C . n 
A 1 142 THR 142 147 147 THR THR C . n 
A 1 143 GLY 143 148 148 GLY GLY C . n 
A 1 144 LYS 144 149 149 LYS LYS C . n 
A 1 145 PRO 145 150 150 PRO PRO C . n 
A 1 146 ALA 146 151 151 ALA ALA C . n 
A 1 147 THR 147 152 152 THR THR C . n 
A 1 148 PHE 148 153 153 PHE PHE C . n 
A 1 149 GLN 149 154 154 GLN GLN C . n 
A 1 150 VAL 150 155 155 VAL VAL C . n 
A 1 151 SER 151 156 156 SER SER C . n 
A 1 152 GLN 152 157 157 GLN GLN C . n 
A 1 153 VAL 153 158 158 VAL VAL C . n 
A 1 154 ILE 154 159 159 ILE ILE C . n 
A 1 155 PRO 155 160 160 PRO PRO C . n 
A 1 156 GLY 156 161 161 GLY GLY C . n 
A 1 157 TRP 157 162 162 TRP TRP C . n 
A 1 158 THR 158 163 163 THR THR C . n 
A 1 159 GLU 159 164 164 GLU GLU C . n 
A 1 160 ALA 160 165 165 ALA ALA C . n 
A 1 161 LEU 161 166 166 LEU LEU C . n 
A 1 162 GLN 162 167 167 GLN GLN C . n 
A 1 163 LEU 163 168 168 LEU LEU C . n 
A 1 164 MET 164 169 169 MET MET C . n 
A 1 165 PRO 165 170 170 PRO PRO C . n 
A 1 166 ALA 166 171 171 ALA ALA C . n 
A 1 167 GLY 167 172 172 GLY GLY C . n 
A 1 168 SER 168 173 173 SER SER C . n 
A 1 169 THR 169 174 174 THR THR C . n 
A 1 170 TRP 170 175 175 TRP TRP C . n 
A 1 171 GLU 171 176 176 GLU GLU C . n 
A 1 172 ILE 172 177 177 ILE ILE C . n 
A 1 173 TYR 173 178 178 TYR TYR C . n 
A 1 174 VAL 174 179 179 VAL VAL C . n 
A 1 175 PRO 175 180 180 PRO PRO C . n 
A 1 176 SER 176 181 181 SER SER C . n 
A 1 177 GLY 177 182 182 GLY GLY C . n 
A 1 178 LEU 178 183 183 LEU LEU C . n 
A 1 179 ALA 179 184 184 ALA ALA C . n 
A 1 180 TYR 180 185 185 TYR TYR C . n 
A 1 181 GLY 181 186 186 GLY GLY C . n 
A 1 182 PRO 182 187 187 PRO PRO C . n 
A 1 183 ARG 183 188 188 ARG ARG C . n 
A 1 184 SER 184 189 189 SER SER C . n 
A 1 185 VAL 185 190 190 VAL VAL C . n 
A 1 186 GLY 186 191 191 GLY GLY C . n 
A 1 187 GLY 187 192 192 GLY GLY C . n 
A 1 188 PRO 188 193 193 PRO PRO C . n 
A 1 189 ILE 189 194 194 ILE ILE C . n 
A 1 190 GLY 190 195 195 GLY GLY C . n 
A 1 191 PRO 191 196 196 PRO PRO C . n 
A 1 192 ASN 192 197 197 ASN ASN C . n 
A 1 193 GLU 193 198 198 GLU GLU C . n 
A 1 194 THR 194 199 199 THR THR C . n 
A 1 195 LEU 195 200 200 LEU LEU C . n 
A 1 196 ILE 196 201 201 ILE ILE C . n 
A 1 197 PHE 197 202 202 PHE PHE C . n 
A 1 198 LYS 198 203 203 LYS LYS C . n 
A 1 199 ILE 199 204 204 ILE ILE C . n 
A 1 200 HIS 200 205 205 HIS HIS C . n 
A 1 201 LEU 201 206 206 LEU LEU C . n 
A 1 202 ILE 202 207 207 ILE ILE C . n 
A 1 203 SER 203 208 208 SER SER C . n 
A 1 204 VAL 204 209 209 VAL VAL C . n 
A 1 205 LYS 205 210 210 LYS LYS C . n 
A 1 206 LYS 206 211 211 LYS LYS C . n 
A 1 207 SER 207 212 212 SER SER C . n 
A 1 208 SER 208 213 213 SER SER C . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 GOL 1  301 302 GOL GOL C . 
C 2 GOL 1  302 303 GOL GOL C . 
D 3 MES 1  303 304 MES MES C . 
E 4 PEG 1  304 305 PEG PEG C . 
F 4 PEG 1  305 307 PEG PEG C . 
G 2 GOL 1  306 308 GOL GOL C . 
H 5 NA  1  307 1   NA  NA  C . 
I 6 HOH 1  401 39  HOH HOH C . 
I 6 HOH 2  402 29  HOH HOH C . 
I 6 HOH 3  403 27  HOH HOH C . 
I 6 HOH 4  404 23  HOH HOH C . 
I 6 HOH 5  405 46  HOH HOH C . 
I 6 HOH 6  406 12  HOH HOH C . 
I 6 HOH 7  407 9   HOH HOH C . 
I 6 HOH 8  408 53  HOH HOH C . 
I 6 HOH 9  409 21  HOH HOH C . 
I 6 HOH 10 410 65  HOH HOH C . 
I 6 HOH 11 411 6   HOH HOH C . 
I 6 HOH 12 412 36  HOH HOH C . 
I 6 HOH 13 413 48  HOH HOH C . 
I 6 HOH 14 414 11  HOH HOH C . 
I 6 HOH 15 415 7   HOH HOH C . 
I 6 HOH 16 416 47  HOH HOH C . 
I 6 HOH 17 417 34  HOH HOH C . 
I 6 HOH 18 418 10  HOH HOH C . 
I 6 HOH 19 419 5   HOH HOH C . 
I 6 HOH 20 420 32  HOH HOH C . 
I 6 HOH 21 421 14  HOH HOH C . 
I 6 HOH 22 422 20  HOH HOH C . 
I 6 HOH 23 423 15  HOH HOH C . 
I 6 HOH 24 424 18  HOH HOH C . 
I 6 HOH 25 425 33  HOH HOH C . 
I 6 HOH 26 426 60  HOH HOH C . 
I 6 HOH 27 427 13  HOH HOH C . 
I 6 HOH 28 428 49  HOH HOH C . 
I 6 HOH 29 429 31  HOH HOH C . 
I 6 HOH 30 430 1   HOH HOH C . 
I 6 HOH 31 431 45  HOH HOH C . 
I 6 HOH 32 432 67  HOH HOH C . 
I 6 HOH 33 433 41  HOH HOH C . 
I 6 HOH 34 434 3   HOH HOH C . 
I 6 HOH 35 435 30  HOH HOH C . 
I 6 HOH 36 436 8   HOH HOH C . 
I 6 HOH 37 437 17  HOH HOH C . 
I 6 HOH 38 438 51  HOH HOH C . 
I 6 HOH 39 439 62  HOH HOH C . 
I 6 HOH 40 440 42  HOH HOH C . 
I 6 HOH 41 441 63  HOH HOH C . 
I 6 HOH 42 442 25  HOH HOH C . 
I 6 HOH 43 443 38  HOH HOH C . 
I 6 HOH 44 444 64  HOH HOH C . 
I 6 HOH 45 445 71  HOH HOH C . 
I 6 HOH 46 446 70  HOH HOH C . 
I 6 HOH 47 447 68  HOH HOH C . 
I 6 HOH 48 448 56  HOH HOH C . 
I 6 HOH 49 449 4   HOH HOH C . 
I 6 HOH 50 450 22  HOH HOH C . 
I 6 HOH 51 451 59  HOH HOH C . 
I 6 HOH 52 452 44  HOH HOH C . 
I 6 HOH 53 453 24  HOH HOH C . 
I 6 HOH 54 454 73  HOH HOH C . 
I 6 HOH 55 455 69  HOH HOH C . 
I 6 HOH 56 456 55  HOH HOH C . 
I 6 HOH 57 457 52  HOH HOH C . 
I 6 HOH 58 458 28  HOH HOH C . 
I 6 HOH 59 459 43  HOH HOH C . 
I 6 HOH 60 460 57  HOH HOH C . 
I 6 HOH 61 461 54  HOH HOH C . 
I 6 HOH 62 462 40  HOH HOH C . 
I 6 HOH 63 463 61  HOH HOH C . 
I 6 HOH 64 464 72  HOH HOH C . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? '(1.20.1_4487: ???)' 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .                    2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .                    3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .                    4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8R39 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     78.444 
_cell.length_a_esd                 ? 
_cell.length_b                     78.444 
_cell.length_b_esd                 ? 
_cell.length_c                     105.176 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8R39 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                96 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 43 21 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8R39 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             3.60 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          65.82 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
;MES 50mM
NaCl 150mM
PEG3350 14%
;
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            298 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-09-28 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.9677 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'ESRF BEAMLINE MASSIF-1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.9677 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   MASSIF-1 
_diffrn_source.pdbx_synchrotron_site       ESRF 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       8R39 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.20 
_reflns.d_resolution_low                               49.06 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     25869 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.9 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                8 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          14 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.95 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.2 
_reflns_shell.d_res_low                                     4.9 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             3405 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.78 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8R39 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.20 
_refine.ls_d_res_low                             49.06 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     17281 
_refine.ls_number_reflns_R_free                  838 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.93 
_refine.ls_percent_reflns_R_free                 4.85 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2203 
_refine.ls_R_factor_R_free                       0.2710 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2178 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.36 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.10 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 26.32 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.24 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.20 
_refine_hist.d_res_low                        49.06 
_refine_hist.number_atoms_solvent             64 
_refine_hist.number_atoms_total               1681 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1572 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         45 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.014  ? 1644 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.474  ? 2203 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 14.223 ? 239  ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.061  ? 243  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.010  ? 280  ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.20 2.34 . . 131 2696 100.00 . . . . 0.2389 . . . . . . . . . . . 0.2842 
'X-RAY DIFFRACTION' 2.34 2.52 . . 137 2685 100.00 . . . . 0.2345 . . . . . . . . . . . 0.2654 
'X-RAY DIFFRACTION' 2.52 2.77 . . 126 2708 100.00 . . . . 0.2430 . . . . . . . . . . . 0.3272 
'X-RAY DIFFRACTION' 2.77 3.17 . . 141 2705 100.00 . . . . 0.2535 . . . . . . . . . . . 0.3030 
'X-RAY DIFFRACTION' 3.17 4.00 . . 151 2740 100.00 . . . . 0.2165 . . . . . . . . . . . 0.2543 
'X-RAY DIFFRACTION' 4.00 4.9  . . 152 2909 100.00 . . . . 0.1958 . . . . . . . . . . . 0.2586 
# 
_struct.entry_id                     8R39 
_struct.title                        'Full-length LpMIP mutant Y16F' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8R39 
_struct_keywords.text            'Potentiator Mutant Legionalla, STRUCTURAL PROTEIN' 
_struct_keywords.pdbx_keywords   'STRUCTURAL PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 3 ? 
E N N 4 ? 
F N N 4 ? 
G N N 2 ? 
H N N 5 ? 
I N N 6 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    A0A2S6FAG4_LEGPN 
_struct_ref.pdbx_db_accession          A0A2S6FAG4 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SLATDKDKLSYSIGADLGKNFKNQGIDVNPEAMAKGMQDAMSGAQLALTEQQMKDVLNKFQKDLMAKRTAEFNKKADENK
VKGEAFLTENKNKPGVVVLPSGLQYKVINSGNGVKPGKSDTVTVEYTGRLIDGTVFDSTEKTGKPATFQVSQVIPGWTEA
LQLMPAGSTWEIYVPSGLAYGPRSVGGPIGPNETLIFKIHLISVKKSS
;
_struct_ref.pdbx_align_begin           28 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8R39 
_struct_ref_seq.pdbx_strand_id                C 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 208 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             A0A2S6FAG4 
_struct_ref_seq.db_align_beg                  28 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  235 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       6 
_struct_ref_seq.pdbx_auth_seq_align_end       213 
# 
_struct_ref_seq_dif.align_id                     1 
_struct_ref_seq_dif.pdbx_pdb_id_code             8R39 
_struct_ref_seq_dif.mon_id                       PHE 
_struct_ref_seq_dif.pdbx_pdb_strand_id           C 
_struct_ref_seq_dif.seq_num                      11 
_struct_ref_seq_dif.pdbx_pdb_ins_code            ? 
_struct_ref_seq_dif.pdbx_seq_db_name             UNP 
_struct_ref_seq_dif.pdbx_seq_db_accession_code   A0A2S6FAG4 
_struct_ref_seq_dif.db_mon_id                    TYR 
_struct_ref_seq_dif.pdbx_seq_db_seq_num          38 
_struct_ref_seq_dif.details                      'engineered mutation' 
_struct_ref_seq_dif.pdbx_auth_seq_num            16 
_struct_ref_seq_dif.pdbx_ordinal                 1 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 5800  ? 
1 MORE         -38   ? 
1 'SSA (A^2)'  24670 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'NMR relaxation study' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'       1_555 x,y,z 1.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 1.0  0.0 
2 'point symmetry operation' ?     ?     0.0 1.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 -1.0 0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 THR A 4   ? GLY A 25  ? THR C 9   GLY C 30  1 ? 22 
HELX_P HELX_P2 AA2 ASN A 29  ? GLY A 43  ? ASN C 34  GLY C 48  1 ? 15 
HELX_P HELX_P3 AA3 THR A 49  ? LYS A 91  ? THR C 54  LYS C 96  1 ? 43 
HELX_P HELX_P4 AA4 THR A 139 ? GLY A 143 ? THR C 144 GLY C 148 1 ? 5  
HELX_P HELX_P5 AA5 SER A 151 ? VAL A 153 ? SER C 156 VAL C 158 5 ? 3  
HELX_P HELX_P6 AA6 ILE A 154 ? GLN A 162 ? ILE C 159 GLN C 167 1 ? 9  
HELX_P HELX_P7 AA7 PRO A 175 ? ALA A 179 ? PRO C 180 ALA C 184 5 ? 5  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1 metalc ? ? A GLU 171 OE1 ? ? ? 1_555 H NA  . NA ? ? C GLU 176 C NA  307 1_555 ? ? ? ? ? ? ? 3.117 ? ? 
metalc2 metalc ? ? H NA  .   NA  ? ? ? 1_555 I HOH . O  ? ? C NA  307 C HOH 406 1_555 ? ? ? ? ? ? ? 3.156 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_struct_conn_angle.id                    1 
_pdbx_struct_conn_angle.ptnr1_label_atom_id   OE1 
_pdbx_struct_conn_angle.ptnr1_label_alt_id    ? 
_pdbx_struct_conn_angle.ptnr1_label_asym_id   A 
_pdbx_struct_conn_angle.ptnr1_label_comp_id   GLU 
_pdbx_struct_conn_angle.ptnr1_label_seq_id    171 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id    ? 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id    C 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id    GLU 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id     176 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code    ? 
_pdbx_struct_conn_angle.ptnr1_symmetry        1_555 
_pdbx_struct_conn_angle.ptnr2_label_atom_id   NA 
_pdbx_struct_conn_angle.ptnr2_label_alt_id    ? 
_pdbx_struct_conn_angle.ptnr2_label_asym_id   H 
_pdbx_struct_conn_angle.ptnr2_label_comp_id   NA 
_pdbx_struct_conn_angle.ptnr2_label_seq_id    . 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id    ? 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id    C 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id    NA 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id     307 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code    ? 
_pdbx_struct_conn_angle.ptnr2_symmetry        1_555 
_pdbx_struct_conn_angle.ptnr3_label_atom_id   O 
_pdbx_struct_conn_angle.ptnr3_label_alt_id    ? 
_pdbx_struct_conn_angle.ptnr3_label_asym_id   I 
_pdbx_struct_conn_angle.ptnr3_label_comp_id   HOH 
_pdbx_struct_conn_angle.ptnr3_label_seq_id    . 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id    ? 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id    C 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id    HOH 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id     406 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code    ? 
_pdbx_struct_conn_angle.ptnr3_symmetry        1_555 
_pdbx_struct_conn_angle.value                 77.7 
_pdbx_struct_conn_angle.value_esd             ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 6 ? 
AA2 ? 6 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA2 5 6 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 97  ? VAL A 98  ? VAL C 102 VAL C 103 
AA1 2 GLN A 104 ? ASN A 109 ? GLN C 109 ASN C 114 
AA1 3 THR A 169 ? VAL A 174 ? THR C 174 VAL C 179 
AA1 4 LEU A 195 ? LYS A 205 ? LEU C 200 LYS C 210 
AA1 5 THR A 121 ? ARG A 129 ? THR C 126 ARG C 134 
AA1 6 VAL A 135 ? SER A 138 ? VAL C 140 SER C 143 
AA2 1 VAL A 97  ? VAL A 98  ? VAL C 102 VAL C 103 
AA2 2 GLN A 104 ? ASN A 109 ? GLN C 109 ASN C 114 
AA2 3 THR A 169 ? VAL A 174 ? THR C 174 VAL C 179 
AA2 4 LEU A 195 ? LYS A 205 ? LEU C 200 LYS C 210 
AA2 5 THR A 121 ? ARG A 129 ? THR C 126 ARG C 134 
AA2 6 ALA A 146 ? GLN A 149 ? ALA C 151 GLN C 154 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N VAL A 97  ? N VAL C 102 O TYR A 105 ? O TYR C 110 
AA1 2 3 N ASN A 109 ? N ASN C 114 O THR A 169 ? O THR C 174 
AA1 3 4 N ILE A 172 ? N ILE C 177 O PHE A 197 ? O PHE C 202 
AA1 4 5 O ILE A 196 ? O ILE C 201 N ARG A 129 ? N ARG C 134 
AA1 5 6 N GLY A 128 ? N GLY C 133 O ASP A 137 ? O ASP C 142 
AA2 1 2 N VAL A 97  ? N VAL C 102 O TYR A 105 ? O TYR C 110 
AA2 2 3 N ASN A 109 ? N ASN C 114 O THR A 169 ? O THR C 174 
AA2 3 4 N ILE A 172 ? N ILE C 177 O PHE A 197 ? O PHE C 202 
AA2 4 5 O ILE A 196 ? O ILE C 201 N ARG A 129 ? N ARG C 134 
AA2 5 6 N VAL A 122 ? N VAL C 127 O PHE A 148 ? O PHE C 153 
# 
_pdbx_entry_details.entry_id                   8R39 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    NE2 
_pdbx_validate_symm_contact.auth_asym_id_1    C 
_pdbx_validate_symm_contact.auth_comp_id_1    HIS 
_pdbx_validate_symm_contact.auth_seq_id_1     205 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    O3S 
_pdbx_validate_symm_contact.auth_asym_id_2    C 
_pdbx_validate_symm_contact.auth_comp_id_2    MES 
_pdbx_validate_symm_contact.auth_seq_id_2     303 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   3_454 
_pdbx_validate_symm_contact.dist              1.25 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 LEU C 7   ? ? -117.89 53.05   
2 1 ALA C 184 ? ? -133.81 -116.96 
3 1 SER C 189 ? ? -159.89 84.55   
# 
loop_
_pdbx_validate_planes.id 
_pdbx_validate_planes.PDB_model_num 
_pdbx_validate_planes.auth_comp_id 
_pdbx_validate_planes.auth_asym_id 
_pdbx_validate_planes.auth_seq_id 
_pdbx_validate_planes.PDB_ins_code 
_pdbx_validate_planes.label_alt_id 
_pdbx_validate_planes.rmsd 
_pdbx_validate_planes.type 
1 1 ARG C 73  ? ? 0.257 'SIDE CHAIN' 
2 1 ARG C 188 ? ? 0.293 'SIDE CHAIN' 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? C HOH 463 ? 5.84 . 
2 1 O ? C HOH 464 ? 5.96 . 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
GLN N    N  N N 74  
GLN CA   C  N S 75  
GLN C    C  N N 76  
GLN O    O  N N 77  
GLN CB   C  N N 78  
GLN CG   C  N N 79  
GLN CD   C  N N 80  
GLN OE1  O  N N 81  
GLN NE2  N  N N 82  
GLN OXT  O  N N 83  
GLN H    H  N N 84  
GLN H2   H  N N 85  
GLN HA   H  N N 86  
GLN HB2  H  N N 87  
GLN HB3  H  N N 88  
GLN HG2  H  N N 89  
GLN HG3  H  N N 90  
GLN HE21 H  N N 91  
GLN HE22 H  N N 92  
GLN HXT  H  N N 93  
GLU N    N  N N 94  
GLU CA   C  N S 95  
GLU C    C  N N 96  
GLU O    O  N N 97  
GLU CB   C  N N 98  
GLU CG   C  N N 99  
GLU CD   C  N N 100 
GLU OE1  O  N N 101 
GLU OE2  O  N N 102 
GLU OXT  O  N N 103 
GLU H    H  N N 104 
GLU H2   H  N N 105 
GLU HA   H  N N 106 
GLU HB2  H  N N 107 
GLU HB3  H  N N 108 
GLU HG2  H  N N 109 
GLU HG3  H  N N 110 
GLU HE2  H  N N 111 
GLU HXT  H  N N 112 
GLY N    N  N N 113 
GLY CA   C  N N 114 
GLY C    C  N N 115 
GLY O    O  N N 116 
GLY OXT  O  N N 117 
GLY H    H  N N 118 
GLY H2   H  N N 119 
GLY HA2  H  N N 120 
GLY HA3  H  N N 121 
GLY HXT  H  N N 122 
GOL C1   C  N N 123 
GOL O1   O  N N 124 
GOL C2   C  N N 125 
GOL O2   O  N N 126 
GOL C3   C  N N 127 
GOL O3   O  N N 128 
GOL H11  H  N N 129 
GOL H12  H  N N 130 
GOL HO1  H  N N 131 
GOL H2   H  N N 132 
GOL HO2  H  N N 133 
GOL H31  H  N N 134 
GOL H32  H  N N 135 
GOL HO3  H  N N 136 
HIS N    N  N N 137 
HIS CA   C  N S 138 
HIS C    C  N N 139 
HIS O    O  N N 140 
HIS CB   C  N N 141 
HIS CG   C  Y N 142 
HIS ND1  N  Y N 143 
HIS CD2  C  Y N 144 
HIS CE1  C  Y N 145 
HIS NE2  N  Y N 146 
HIS OXT  O  N N 147 
HIS H    H  N N 148 
HIS H2   H  N N 149 
HIS HA   H  N N 150 
HIS HB2  H  N N 151 
HIS HB3  H  N N 152 
HIS HD1  H  N N 153 
HIS HD2  H  N N 154 
HIS HE1  H  N N 155 
HIS HE2  H  N N 156 
HIS HXT  H  N N 157 
HOH O    O  N N 158 
HOH H1   H  N N 159 
HOH H2   H  N N 160 
ILE N    N  N N 161 
ILE CA   C  N S 162 
ILE C    C  N N 163 
ILE O    O  N N 164 
ILE CB   C  N S 165 
ILE CG1  C  N N 166 
ILE CG2  C  N N 167 
ILE CD1  C  N N 168 
ILE OXT  O  N N 169 
ILE H    H  N N 170 
ILE H2   H  N N 171 
ILE HA   H  N N 172 
ILE HB   H  N N 173 
ILE HG12 H  N N 174 
ILE HG13 H  N N 175 
ILE HG21 H  N N 176 
ILE HG22 H  N N 177 
ILE HG23 H  N N 178 
ILE HD11 H  N N 179 
ILE HD12 H  N N 180 
ILE HD13 H  N N 181 
ILE HXT  H  N N 182 
LEU N    N  N N 183 
LEU CA   C  N S 184 
LEU C    C  N N 185 
LEU O    O  N N 186 
LEU CB   C  N N 187 
LEU CG   C  N N 188 
LEU CD1  C  N N 189 
LEU CD2  C  N N 190 
LEU OXT  O  N N 191 
LEU H    H  N N 192 
LEU H2   H  N N 193 
LEU HA   H  N N 194 
LEU HB2  H  N N 195 
LEU HB3  H  N N 196 
LEU HG   H  N N 197 
LEU HD11 H  N N 198 
LEU HD12 H  N N 199 
LEU HD13 H  N N 200 
LEU HD21 H  N N 201 
LEU HD22 H  N N 202 
LEU HD23 H  N N 203 
LEU HXT  H  N N 204 
LYS N    N  N N 205 
LYS CA   C  N S 206 
LYS C    C  N N 207 
LYS O    O  N N 208 
LYS CB   C  N N 209 
LYS CG   C  N N 210 
LYS CD   C  N N 211 
LYS CE   C  N N 212 
LYS NZ   N  N N 213 
LYS OXT  O  N N 214 
LYS H    H  N N 215 
LYS H2   H  N N 216 
LYS HA   H  N N 217 
LYS HB2  H  N N 218 
LYS HB3  H  N N 219 
LYS HG2  H  N N 220 
LYS HG3  H  N N 221 
LYS HD2  H  N N 222 
LYS HD3  H  N N 223 
LYS HE2  H  N N 224 
LYS HE3  H  N N 225 
LYS HZ1  H  N N 226 
LYS HZ2  H  N N 227 
LYS HZ3  H  N N 228 
LYS HXT  H  N N 229 
MES O1   O  N N 230 
MES C2   C  N N 231 
MES C3   C  N N 232 
MES N4   N  N N 233 
MES C5   C  N N 234 
MES C6   C  N N 235 
MES C7   C  N N 236 
MES C8   C  N N 237 
MES S    S  N N 238 
MES O1S  O  N N 239 
MES O2S  O  N N 240 
MES O3S  O  N N 241 
MES H21  H  N N 242 
MES H22  H  N N 243 
MES H31  H  N N 244 
MES H32  H  N N 245 
MES HN4  H  N N 246 
MES H51  H  N N 247 
MES H52  H  N N 248 
MES H61  H  N N 249 
MES H62  H  N N 250 
MES H71  H  N N 251 
MES H72  H  N N 252 
MES H81  H  N N 253 
MES H82  H  N N 254 
MET N    N  N N 255 
MET CA   C  N S 256 
MET C    C  N N 257 
MET O    O  N N 258 
MET CB   C  N N 259 
MET CG   C  N N 260 
MET SD   S  N N 261 
MET CE   C  N N 262 
MET OXT  O  N N 263 
MET H    H  N N 264 
MET H2   H  N N 265 
MET HA   H  N N 266 
MET HB2  H  N N 267 
MET HB3  H  N N 268 
MET HG2  H  N N 269 
MET HG3  H  N N 270 
MET HE1  H  N N 271 
MET HE2  H  N N 272 
MET HE3  H  N N 273 
MET HXT  H  N N 274 
NA  NA   NA N N 275 
PEG C1   C  N N 276 
PEG O1   O  N N 277 
PEG C2   C  N N 278 
PEG O2   O  N N 279 
PEG C3   C  N N 280 
PEG C4   C  N N 281 
PEG O4   O  N N 282 
PEG H11  H  N N 283 
PEG H12  H  N N 284 
PEG HO1  H  N N 285 
PEG H21  H  N N 286 
PEG H22  H  N N 287 
PEG H31  H  N N 288 
PEG H32  H  N N 289 
PEG H41  H  N N 290 
PEG H42  H  N N 291 
PEG HO4  H  N N 292 
PHE N    N  N N 293 
PHE CA   C  N S 294 
PHE C    C  N N 295 
PHE O    O  N N 296 
PHE CB   C  N N 297 
PHE CG   C  Y N 298 
PHE CD1  C  Y N 299 
PHE CD2  C  Y N 300 
PHE CE1  C  Y N 301 
PHE CE2  C  Y N 302 
PHE CZ   C  Y N 303 
PHE OXT  O  N N 304 
PHE H    H  N N 305 
PHE H2   H  N N 306 
PHE HA   H  N N 307 
PHE HB2  H  N N 308 
PHE HB3  H  N N 309 
PHE HD1  H  N N 310 
PHE HD2  H  N N 311 
PHE HE1  H  N N 312 
PHE HE2  H  N N 313 
PHE HZ   H  N N 314 
PHE HXT  H  N N 315 
PRO N    N  N N 316 
PRO CA   C  N S 317 
PRO C    C  N N 318 
PRO O    O  N N 319 
PRO CB   C  N N 320 
PRO CG   C  N N 321 
PRO CD   C  N N 322 
PRO OXT  O  N N 323 
PRO H    H  N N 324 
PRO HA   H  N N 325 
PRO HB2  H  N N 326 
PRO HB3  H  N N 327 
PRO HG2  H  N N 328 
PRO HG3  H  N N 329 
PRO HD2  H  N N 330 
PRO HD3  H  N N 331 
PRO HXT  H  N N 332 
SER N    N  N N 333 
SER CA   C  N S 334 
SER C    C  N N 335 
SER O    O  N N 336 
SER CB   C  N N 337 
SER OG   O  N N 338 
SER OXT  O  N N 339 
SER H    H  N N 340 
SER H2   H  N N 341 
SER HA   H  N N 342 
SER HB2  H  N N 343 
SER HB3  H  N N 344 
SER HG   H  N N 345 
SER HXT  H  N N 346 
THR N    N  N N 347 
THR CA   C  N S 348 
THR C    C  N N 349 
THR O    O  N N 350 
THR CB   C  N R 351 
THR OG1  O  N N 352 
THR CG2  C  N N 353 
THR OXT  O  N N 354 
THR H    H  N N 355 
THR H2   H  N N 356 
THR HA   H  N N 357 
THR HB   H  N N 358 
THR HG1  H  N N 359 
THR HG21 H  N N 360 
THR HG22 H  N N 361 
THR HG23 H  N N 362 
THR HXT  H  N N 363 
TRP N    N  N N 364 
TRP CA   C  N S 365 
TRP C    C  N N 366 
TRP O    O  N N 367 
TRP CB   C  N N 368 
TRP CG   C  Y N 369 
TRP CD1  C  Y N 370 
TRP CD2  C  Y N 371 
TRP NE1  N  Y N 372 
TRP CE2  C  Y N 373 
TRP CE3  C  Y N 374 
TRP CZ2  C  Y N 375 
TRP CZ3  C  Y N 376 
TRP CH2  C  Y N 377 
TRP OXT  O  N N 378 
TRP H    H  N N 379 
TRP H2   H  N N 380 
TRP HA   H  N N 381 
TRP HB2  H  N N 382 
TRP HB3  H  N N 383 
TRP HD1  H  N N 384 
TRP HE1  H  N N 385 
TRP HE3  H  N N 386 
TRP HZ2  H  N N 387 
TRP HZ3  H  N N 388 
TRP HH2  H  N N 389 
TRP HXT  H  N N 390 
TYR N    N  N N 391 
TYR CA   C  N S 392 
TYR C    C  N N 393 
TYR O    O  N N 394 
TYR CB   C  N N 395 
TYR CG   C  Y N 396 
TYR CD1  C  Y N 397 
TYR CD2  C  Y N 398 
TYR CE1  C  Y N 399 
TYR CE2  C  Y N 400 
TYR CZ   C  Y N 401 
TYR OH   O  N N 402 
TYR OXT  O  N N 403 
TYR H    H  N N 404 
TYR H2   H  N N 405 
TYR HA   H  N N 406 
TYR HB2  H  N N 407 
TYR HB3  H  N N 408 
TYR HD1  H  N N 409 
TYR HD2  H  N N 410 
TYR HE1  H  N N 411 
TYR HE2  H  N N 412 
TYR HH   H  N N 413 
TYR HXT  H  N N 414 
VAL N    N  N N 415 
VAL CA   C  N S 416 
VAL C    C  N N 417 
VAL O    O  N N 418 
VAL CB   C  N N 419 
VAL CG1  C  N N 420 
VAL CG2  C  N N 421 
VAL OXT  O  N N 422 
VAL H    H  N N 423 
VAL H2   H  N N 424 
VAL HA   H  N N 425 
VAL HB   H  N N 426 
VAL HG11 H  N N 427 
VAL HG12 H  N N 428 
VAL HG13 H  N N 429 
VAL HG21 H  N N 430 
VAL HG22 H  N N 431 
VAL HG23 H  N N 432 
VAL HXT  H  N N 433 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
GLN N   CA   sing N N 70  
GLN N   H    sing N N 71  
GLN N   H2   sing N N 72  
GLN CA  C    sing N N 73  
GLN CA  CB   sing N N 74  
GLN CA  HA   sing N N 75  
GLN C   O    doub N N 76  
GLN C   OXT  sing N N 77  
GLN CB  CG   sing N N 78  
GLN CB  HB2  sing N N 79  
GLN CB  HB3  sing N N 80  
GLN CG  CD   sing N N 81  
GLN CG  HG2  sing N N 82  
GLN CG  HG3  sing N N 83  
GLN CD  OE1  doub N N 84  
GLN CD  NE2  sing N N 85  
GLN NE2 HE21 sing N N 86  
GLN NE2 HE22 sing N N 87  
GLN OXT HXT  sing N N 88  
GLU N   CA   sing N N 89  
GLU N   H    sing N N 90  
GLU N   H2   sing N N 91  
GLU CA  C    sing N N 92  
GLU CA  CB   sing N N 93  
GLU CA  HA   sing N N 94  
GLU C   O    doub N N 95  
GLU C   OXT  sing N N 96  
GLU CB  CG   sing N N 97  
GLU CB  HB2  sing N N 98  
GLU CB  HB3  sing N N 99  
GLU CG  CD   sing N N 100 
GLU CG  HG2  sing N N 101 
GLU CG  HG3  sing N N 102 
GLU CD  OE1  doub N N 103 
GLU CD  OE2  sing N N 104 
GLU OE2 HE2  sing N N 105 
GLU OXT HXT  sing N N 106 
GLY N   CA   sing N N 107 
GLY N   H    sing N N 108 
GLY N   H2   sing N N 109 
GLY CA  C    sing N N 110 
GLY CA  HA2  sing N N 111 
GLY CA  HA3  sing N N 112 
GLY C   O    doub N N 113 
GLY C   OXT  sing N N 114 
GLY OXT HXT  sing N N 115 
GOL C1  O1   sing N N 116 
GOL C1  C2   sing N N 117 
GOL C1  H11  sing N N 118 
GOL C1  H12  sing N N 119 
GOL O1  HO1  sing N N 120 
GOL C2  O2   sing N N 121 
GOL C2  C3   sing N N 122 
GOL C2  H2   sing N N 123 
GOL O2  HO2  sing N N 124 
GOL C3  O3   sing N N 125 
GOL C3  H31  sing N N 126 
GOL C3  H32  sing N N 127 
GOL O3  HO3  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MES O1  C2   sing N N 218 
MES O1  C6   sing N N 219 
MES C2  C3   sing N N 220 
MES C2  H21  sing N N 221 
MES C2  H22  sing N N 222 
MES C3  N4   sing N N 223 
MES C3  H31  sing N N 224 
MES C3  H32  sing N N 225 
MES N4  C5   sing N N 226 
MES N4  C7   sing N N 227 
MES N4  HN4  sing N N 228 
MES C5  C6   sing N N 229 
MES C5  H51  sing N N 230 
MES C5  H52  sing N N 231 
MES C6  H61  sing N N 232 
MES C6  H62  sing N N 233 
MES C7  C8   sing N N 234 
MES C7  H71  sing N N 235 
MES C7  H72  sing N N 236 
MES C8  S    sing N N 237 
MES C8  H81  sing N N 238 
MES C8  H82  sing N N 239 
MES S   O1S  doub N N 240 
MES S   O2S  doub N N 241 
MES S   O3S  sing N N 242 
MET N   CA   sing N N 243 
MET N   H    sing N N 244 
MET N   H2   sing N N 245 
MET CA  C    sing N N 246 
MET CA  CB   sing N N 247 
MET CA  HA   sing N N 248 
MET C   O    doub N N 249 
MET C   OXT  sing N N 250 
MET CB  CG   sing N N 251 
MET CB  HB2  sing N N 252 
MET CB  HB3  sing N N 253 
MET CG  SD   sing N N 254 
MET CG  HG2  sing N N 255 
MET CG  HG3  sing N N 256 
MET SD  CE   sing N N 257 
MET CE  HE1  sing N N 258 
MET CE  HE2  sing N N 259 
MET CE  HE3  sing N N 260 
MET OXT HXT  sing N N 261 
PEG C1  O1   sing N N 262 
PEG C1  C2   sing N N 263 
PEG C1  H11  sing N N 264 
PEG C1  H12  sing N N 265 
PEG O1  HO1  sing N N 266 
PEG C2  O2   sing N N 267 
PEG C2  H21  sing N N 268 
PEG C2  H22  sing N N 269 
PEG O2  C3   sing N N 270 
PEG C3  C4   sing N N 271 
PEG C3  H31  sing N N 272 
PEG C3  H32  sing N N 273 
PEG C4  O4   sing N N 274 
PEG C4  H41  sing N N 275 
PEG C4  H42  sing N N 276 
PEG O4  HO4  sing N N 277 
PHE N   CA   sing N N 278 
PHE N   H    sing N N 279 
PHE N   H2   sing N N 280 
PHE CA  C    sing N N 281 
PHE CA  CB   sing N N 282 
PHE CA  HA   sing N N 283 
PHE C   O    doub N N 284 
PHE C   OXT  sing N N 285 
PHE CB  CG   sing N N 286 
PHE CB  HB2  sing N N 287 
PHE CB  HB3  sing N N 288 
PHE CG  CD1  doub Y N 289 
PHE CG  CD2  sing Y N 290 
PHE CD1 CE1  sing Y N 291 
PHE CD1 HD1  sing N N 292 
PHE CD2 CE2  doub Y N 293 
PHE CD2 HD2  sing N N 294 
PHE CE1 CZ   doub Y N 295 
PHE CE1 HE1  sing N N 296 
PHE CE2 CZ   sing Y N 297 
PHE CE2 HE2  sing N N 298 
PHE CZ  HZ   sing N N 299 
PHE OXT HXT  sing N N 300 
PRO N   CA   sing N N 301 
PRO N   CD   sing N N 302 
PRO N   H    sing N N 303 
PRO CA  C    sing N N 304 
PRO CA  CB   sing N N 305 
PRO CA  HA   sing N N 306 
PRO C   O    doub N N 307 
PRO C   OXT  sing N N 308 
PRO CB  CG   sing N N 309 
PRO CB  HB2  sing N N 310 
PRO CB  HB3  sing N N 311 
PRO CG  CD   sing N N 312 
PRO CG  HG2  sing N N 313 
PRO CG  HG3  sing N N 314 
PRO CD  HD2  sing N N 315 
PRO CD  HD3  sing N N 316 
PRO OXT HXT  sing N N 317 
SER N   CA   sing N N 318 
SER N   H    sing N N 319 
SER N   H2   sing N N 320 
SER CA  C    sing N N 321 
SER CA  CB   sing N N 322 
SER CA  HA   sing N N 323 
SER C   O    doub N N 324 
SER C   OXT  sing N N 325 
SER CB  OG   sing N N 326 
SER CB  HB2  sing N N 327 
SER CB  HB3  sing N N 328 
SER OG  HG   sing N N 329 
SER OXT HXT  sing N N 330 
THR N   CA   sing N N 331 
THR N   H    sing N N 332 
THR N   H2   sing N N 333 
THR CA  C    sing N N 334 
THR CA  CB   sing N N 335 
THR CA  HA   sing N N 336 
THR C   O    doub N N 337 
THR C   OXT  sing N N 338 
THR CB  OG1  sing N N 339 
THR CB  CG2  sing N N 340 
THR CB  HB   sing N N 341 
THR OG1 HG1  sing N N 342 
THR CG2 HG21 sing N N 343 
THR CG2 HG22 sing N N 344 
THR CG2 HG23 sing N N 345 
THR OXT HXT  sing N N 346 
TRP N   CA   sing N N 347 
TRP N   H    sing N N 348 
TRP N   H2   sing N N 349 
TRP CA  C    sing N N 350 
TRP CA  CB   sing N N 351 
TRP CA  HA   sing N N 352 
TRP C   O    doub N N 353 
TRP C   OXT  sing N N 354 
TRP CB  CG   sing N N 355 
TRP CB  HB2  sing N N 356 
TRP CB  HB3  sing N N 357 
TRP CG  CD1  doub Y N 358 
TRP CG  CD2  sing Y N 359 
TRP CD1 NE1  sing Y N 360 
TRP CD1 HD1  sing N N 361 
TRP CD2 CE2  doub Y N 362 
TRP CD2 CE3  sing Y N 363 
TRP NE1 CE2  sing Y N 364 
TRP NE1 HE1  sing N N 365 
TRP CE2 CZ2  sing Y N 366 
TRP CE3 CZ3  doub Y N 367 
TRP CE3 HE3  sing N N 368 
TRP CZ2 CH2  doub Y N 369 
TRP CZ2 HZ2  sing N N 370 
TRP CZ3 CH2  sing Y N 371 
TRP CZ3 HZ3  sing N N 372 
TRP CH2 HH2  sing N N 373 
TRP OXT HXT  sing N N 374 
TYR N   CA   sing N N 375 
TYR N   H    sing N N 376 
TYR N   H2   sing N N 377 
TYR CA  C    sing N N 378 
TYR CA  CB   sing N N 379 
TYR CA  HA   sing N N 380 
TYR C   O    doub N N 381 
TYR C   OXT  sing N N 382 
TYR CB  CG   sing N N 383 
TYR CB  HB2  sing N N 384 
TYR CB  HB3  sing N N 385 
TYR CG  CD1  doub Y N 386 
TYR CG  CD2  sing Y N 387 
TYR CD1 CE1  sing Y N 388 
TYR CD1 HD1  sing N N 389 
TYR CD2 CE2  doub Y N 390 
TYR CD2 HD2  sing N N 391 
TYR CE1 CZ   doub Y N 392 
TYR CE1 HE1  sing N N 393 
TYR CE2 CZ   sing Y N 394 
TYR CE2 HE2  sing N N 395 
TYR CZ  OH   sing N N 396 
TYR OH  HH   sing N N 397 
TYR OXT HXT  sing N N 398 
VAL N   CA   sing N N 399 
VAL N   H    sing N N 400 
VAL N   H2   sing N N 401 
VAL CA  C    sing N N 402 
VAL CA  CB   sing N N 403 
VAL CA  HA   sing N N 404 
VAL C   O    doub N N 405 
VAL C   OXT  sing N N 406 
VAL CB  CG1  sing N N 407 
VAL CB  CG2  sing N N 408 
VAL CB  HB   sing N N 409 
VAL CG1 HG11 sing N N 410 
VAL CG1 HG12 sing N N 411 
VAL CG1 HG13 sing N N 412 
VAL CG2 HG21 sing N N 413 
VAL CG2 HG22 sing N N 414 
VAL CG2 HG23 sing N N 415 
VAL OXT HXT  sing N N 416 
# 
_pdbx_audit_support.funding_organization   'German Research Foundation (DFG)' 
_pdbx_audit_support.country                Germany 
_pdbx_audit_support.grant_number           390713860 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   8BJC 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8R39 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.012748 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.012748 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009508 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
H  
N  
NA 
O  
S  
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N    . SER A 1 1   ? 22.197  18.659  -10.823 1.00 79.30  ? 6   SER C N    1 
ATOM   2    C  CA   . SER A 1 1   ? 22.634  17.895  -12.021 1.00 90.00  ? 6   SER C CA   1 
ATOM   3    C  C    . SER A 1 1   ? 21.747  16.669  -12.235 1.00 80.77  ? 6   SER C C    1 
ATOM   4    O  O    . SER A 1 1   ? 21.652  15.872  -11.287 1.00 78.75  ? 6   SER C O    1 
ATOM   5    C  CB   . SER A 1 1   ? 24.068  17.467  -11.904 1.00 95.37  ? 6   SER C CB   1 
ATOM   6    O  OG   . SER A 1 1   ? 24.390  16.479  -12.873 1.00 81.34  ? 6   SER C OG   1 
ATOM   7    H  HA   . SER A 1 1   ? 22.547  18.482  -12.813 1.00 108.05 ? 6   SER C HA   1 
ATOM   8    H  HB2  . SER A 1 1   ? 24.647  18.242  -12.026 1.00 114.49 ? 6   SER C HB2  1 
ATOM   9    H  HB3  . SER A 1 1   ? 24.225  17.107  -11.011 1.00 114.49 ? 6   SER C HB3  1 
ATOM   10   H  HG   . SER A 1 1   ? 24.171  16.762  -13.641 1.00 97.65  ? 6   SER C HG   1 
ATOM   11   N  N    . LEU A 1 2   ? 21.149  16.527  -13.419 1.00 67.64  ? 7   LEU C N    1 
ATOM   12   C  CA   . LEU A 1 2   ? 20.356  15.328  -13.779 1.00 62.15  ? 7   LEU C CA   1 
ATOM   13   C  C    . LEU A 1 2   ? 21.084  14.705  -14.973 1.00 61.71  ? 7   LEU C C    1 
ATOM   14   O  O    . LEU A 1 2   ? 20.448  14.502  -16.006 1.00 62.32  ? 7   LEU C O    1 
ATOM   15   C  CB   . LEU A 1 2   ? 18.904  15.689  -14.073 1.00 60.12  ? 7   LEU C CB   1 
ATOM   16   C  CG   . LEU A 1 2   ? 18.097  16.275  -12.912 1.00 55.58  ? 7   LEU C CG   1 
ATOM   17   C  CD1  . LEU A 1 2   ? 16.636  16.269  -13.290 1.00 57.75  ? 7   LEU C CD1  1 
ATOM   18   C  CD2  . LEU A 1 2   ? 18.281  15.527  -11.614 1.00 60.64  ? 7   LEU C CD2  1 
ATOM   19   H  H    . LEU A 1 2   ? 21.207  17.163  -14.055 1.00 81.21  ? 7   LEU C H    1 
ATOM   20   H  HA   . LEU A 1 2   ? 20.388  14.683  -13.034 1.00 74.63  ? 7   LEU C HA   1 
ATOM   21   H  HB2  . LEU A 1 2   ? 18.894  16.337  -14.813 1.00 72.18  ? 7   LEU C HB2  1 
ATOM   22   H  HB3  . LEU A 1 2   ? 18.443  14.874  -14.380 1.00 72.18  ? 7   LEU C HB3  1 
ATOM   23   H  HG   . LEU A 1 2   ? 18.382  17.214  -12.776 1.00 66.74  ? 7   LEU C HG   1 
ATOM   24   H  HD11 . LEU A 1 2   ? 16.186  17.018  -12.865 1.00 69.34  ? 7   LEU C HD11 1 
ATOM   25   H  HD12 . LEU A 1 2   ? 16.550  16.344  -14.255 1.00 69.34  ? 7   LEU C HD12 1 
ATOM   26   H  HD13 . LEU A 1 2   ? 16.230  15.438  -12.992 1.00 69.34  ? 7   LEU C HD13 1 
ATOM   27   H  HD21 . LEU A 1 2   ? 17.511  15.680  -11.043 1.00 72.81  ? 7   LEU C HD21 1 
ATOM   28   H  HD22 . LEU A 1 2   ? 18.364  14.576  -11.797 1.00 72.81  ? 7   LEU C HD22 1 
ATOM   29   H  HD23 . LEU A 1 2   ? 19.081  15.841  -11.166 1.00 72.81  ? 7   LEU C HD23 1 
ATOM   30   N  N    . ALA A 1 3   ? 22.382  14.450  -14.836 1.00 54.65  ? 8   ALA C N    1 
ATOM   31   C  CA   . ALA A 1 3   ? 23.211  13.877  -15.913 1.00 49.36  ? 8   ALA C CA   1 
ATOM   32   C  C    . ALA A 1 3   ? 23.163  12.358  -15.880 1.00 57.33  ? 8   ALA C C    1 
ATOM   33   O  O    . ALA A 1 3   ? 23.213  11.771  -16.973 1.00 58.56  ? 8   ALA C O    1 
ATOM   34   C  CB   . ALA A 1 3   ? 24.619  14.343  -15.730 1.00 49.38  ? 8   ALA C CB   1 
ATOM   35   H  H    . ALA A 1 3   ? 22.834  14.616  -14.073 1.00 65.62  ? 8   ALA C H    1 
ATOM   36   H  HA   . ALA A 1 3   ? 22.867  14.191  -16.792 1.00 59.27  ? 8   ALA C HA   1 
ATOM   37   H  HB1  . ALA A 1 3   ? 25.129  14.168  -16.538 1.00 59.30  ? 8   ALA C HB1  1 
ATOM   38   H  HB2  . ALA A 1 3   ? 24.625  15.297  -15.544 1.00 59.30  ? 8   ALA C HB2  1 
ATOM   39   H  HB3  . ALA A 1 3   ? 25.023  13.868  -14.984 1.00 59.30  ? 8   ALA C HB3  1 
ATOM   40   N  N    . THR A 1 4   ? 23.077  11.750  -14.699 1.00 52.04  ? 9   THR C N    1 
ATOM   41   C  CA   . THR A 1 4   ? 23.136  10.286  -14.533 1.00 50.90  ? 9   THR C CA   1 
ATOM   42   C  C    . THR A 1 4   ? 21.756  9.718   -14.348 1.00 48.32  ? 9   THR C C    1 
ATOM   43   O  O    . THR A 1 4   ? 20.840  10.489  -14.035 1.00 49.21  ? 9   THR C O    1 
ATOM   44   C  CB   . THR A 1 4   ? 24.034  9.971   -13.340 1.00 55.11  ? 9   THR C CB   1 
ATOM   45   O  OG1  . THR A 1 4   ? 23.275  10.265  -12.175 1.00 49.38  ? 9   THR C OG1  1 
ATOM   46   C  CG2  . THR A 1 4   ? 25.303  10.802  -13.342 1.00 55.12  ? 9   THR C CG2  1 
ATOM   47   H  H    . THR A 1 4   ? 22.948  12.185  -13.919 1.00 62.49  ? 9   THR C H    1 
ATOM   48   H  HA   . THR A 1 4   ? 23.536  9.891   -15.335 1.00 61.12  ? 9   THR C HA   1 
ATOM   49   H  HB   . THR A 1 4   ? 24.269  9.013   -13.345 1.00 66.17  ? 9   THR C HB   1 
ATOM   50   H  HG1  . THR A 1 4   ? 23.808  10.436  -11.519 1.00 59.30  ? 9   THR C HG1  1 
ATOM   51   H  HG21 . THR A 1 4   ? 25.994  10.338  -12.840 1.00 66.18  ? 9   THR C HG21 1 
ATOM   52   H  HG22 . THR A 1 4   ? 25.602  10.937  -14.256 1.00 66.18  ? 9   THR C HG22 1 
ATOM   53   H  HG23 . THR A 1 4   ? 25.127  11.664  -12.928 1.00 66.18  ? 9   THR C HG23 1 
ATOM   54   N  N    . ASP A 1 5   ? 21.608  8.413   -14.548 1.00 44.95  ? 10  ASP C N    1 
ATOM   55   C  CA   . ASP A 1 5   ? 20.316  7.730   -14.308 1.00 46.79  ? 10  ASP C CA   1 
ATOM   56   C  C    . ASP A 1 5   ? 19.982  7.800   -12.818 1.00 44.58  ? 10  ASP C C    1 
ATOM   57   O  O    . ASP A 1 5   ? 18.788  7.863   -12.501 1.00 46.80  ? 10  ASP C O    1 
ATOM   58   C  CB   . ASP A 1 5   ? 20.354  6.285   -14.759 1.00 51.79  ? 10  ASP C CB   1 
ATOM   59   C  CG   . ASP A 1 5   ? 20.499  6.025   -16.249 1.00 66.95  ? 10  ASP C CG   1 
ATOM   60   O  OD1  . ASP A 1 5   ? 20.246  6.944   -17.051 1.00 69.96  ? 10  ASP C OD1  1 
ATOM   61   O  OD2  . ASP A 1 5   ? 20.857  4.889   -16.585 1.00 71.31  ? 10  ASP C OD2  1 
ATOM   62   H  H    . ASP A 1 5   ? 22.291  7.894   -14.828 1.00 53.99  ? 10  ASP C H    1 
ATOM   63   H  HA   . ASP A 1 5   ? 19.616  8.204   -14.809 1.00 56.19  ? 10  ASP C HA   1 
ATOM   64   H  HB2  . ASP A 1 5   ? 21.109  5.853   -14.308 1.00 62.20  ? 10  ASP C HB2  1 
ATOM   65   H  HB3  . ASP A 1 5   ? 19.534  5.847   -14.454 1.00 62.20  ? 10  ASP C HB3  1 
ATOM   66   N  N    . LYS A 1 6   ? 20.992  7.778   -11.951 1.00 33.57  ? 11  LYS C N    1 
ATOM   67   C  CA   . LYS A 1 6   ? 20.787  7.871   -10.484 1.00 44.50  ? 11  LYS C CA   1 
ATOM   68   C  C    . LYS A 1 6   ? 20.105  9.212   -10.158 1.00 42.77  ? 11  LYS C C    1 
ATOM   69   O  O    . LYS A 1 6   ? 19.103  9.200   -9.434  1.00 39.61  ? 11  LYS C O    1 
ATOM   70   C  CB   . LYS A 1 6   ? 22.134  7.704   -9.775  1.00 39.63  ? 11  LYS C CB   1 
ATOM   71   C  CG   . LYS A 1 6   ? 22.105  7.758   -8.263  1.00 50.34  ? 11  LYS C CG   1 
ATOM   72   C  CD   . LYS A 1 6   ? 23.479  7.539   -7.650  1.00 52.74  ? 11  LYS C CD   1 
ATOM   73   C  CE   . LYS A 1 6   ? 23.472  7.685   -6.170  1.00 53.54  ? 11  LYS C CE   1 
ATOM   74   N  NZ   . LYS A 1 6   ? 24.766  7.310   -5.601  1.00 59.84  ? 11  LYS C NZ   1 
ATOM   75   H  H    . LYS A 1 6   ? 21.847  7.697   -12.227 1.00 40.33  ? 11  LYS C H    1 
ATOM   76   H  HA   . LYS A 1 6   ? 20.189  7.134   -10.206 1.00 53.44  ? 11  LYS C HA   1 
ATOM   77   H  HB2  . LYS A 1 6   ? 22.516  6.842   -10.042 1.00 47.60  ? 11  LYS C HB2  1 
ATOM   78   H  HB3  . LYS A 1 6   ? 22.740  8.405   -10.094 1.00 47.60  ? 11  LYS C HB3  1 
ATOM   79   H  HG2  . LYS A 1 6   ? 21.762  8.635   -7.983  1.00 60.45  ? 11  LYS C HG2  1 
ATOM   80   H  HG3  . LYS A 1 6   ? 21.490  7.068   -7.934  1.00 60.45  ? 11  LYS C HG3  1 
ATOM   81   H  HD2  . LYS A 1 6   ? 23.792  6.638   -7.881  1.00 63.34  ? 11  LYS C HD2  1 
ATOM   82   H  HD3  . LYS A 1 6   ? 24.108  8.188   -8.032  1.00 63.34  ? 11  LYS C HD3  1 
ATOM   83   H  HE2  . LYS A 1 6   ? 23.274  8.608   -5.934  1.00 64.29  ? 11  LYS C HE2  1 
ATOM   84   H  HE3  . LYS A 1 6   ? 22.780  7.115   -5.791  1.00 64.29  ? 11  LYS C HE3  1 
ATOM   85   H  HZ1  . LYS A 1 6   ? 24.764  7.462   -4.709  1.00 71.85  ? 11  LYS C HZ1  1 
ATOM   86   H  HZ2  . LYS A 1 6   ? 24.922  6.432   -5.757  1.00 71.85  ? 11  LYS C HZ2  1 
ATOM   87   H  HZ3  . LYS A 1 6   ? 25.419  7.802   -5.990  1.00 71.85  ? 11  LYS C HZ3  1 
ATOM   88   N  N    . ASP A 1 7   ? 20.616  10.311  -10.702 1.00 39.58  ? 12  ASP C N    1 
ATOM   89   C  CA   . ASP A 1 7   ? 20.056  11.661  -10.459 1.00 39.99  ? 12  ASP C CA   1 
ATOM   90   C  C    . ASP A 1 7   ? 18.620  11.746  -10.980 1.00 41.01  ? 12  ASP C C    1 
ATOM   91   O  O    . ASP A 1 7   ? 17.775  12.287  -10.270 1.00 39.58  ? 12  ASP C O    1 
ATOM   92   C  CB   . ASP A 1 7   ? 20.924  12.703  -11.132 1.00 45.37  ? 12  ASP C CB   1 
ATOM   93   C  CG   . ASP A 1 7   ? 22.344  12.847  -10.608 1.00 55.60  ? 12  ASP C CG   1 
ATOM   94   O  OD1  . ASP A 1 7   ? 22.539  12.701  -9.386  1.00 56.94  ? 12  ASP C OD1  1 
ATOM   95   O  OD2  . ASP A 1 7   ? 23.241  13.111  -11.431 1.00 64.44  ? 12  ASP C OD2  1 
ATOM   96   H  H    . ASP A 1 7   ? 21.320  10.273  -11.265 1.00 47.54  ? 12  ASP C H    1 
ATOM   97   H  HA   . ASP A 1 7   ? 20.049  11.826  -9.491  1.00 48.03  ? 12  ASP C HA   1 
ATOM   98   H  HB2  . ASP A 1 7   ? 20.979  12.489  -12.088 1.00 54.48  ? 12  ASP C HB2  1 
ATOM   99   H  HB3  . ASP A 1 7   ? 20.469  13.565  -11.051 1.00 54.48  ? 12  ASP C HB3  1 
ATOM   100  N  N    . LYS A 1 8   ? 18.361  11.226  -12.170 1.00 38.51  ? 13  LYS C N    1 
ATOM   101  C  CA   . LYS A 1 8   ? 17.033  11.339  -12.811 1.00 35.78  ? 13  LYS C CA   1 
ATOM   102  C  C    . LYS A 1 8   ? 16.007  10.505  -12.046 1.00 39.75  ? 13  LYS C C    1 
ATOM   103  O  O    . LYS A 1 8   ? 14.888  10.988  -11.881 1.00 43.74  ? 13  LYS C O    1 
ATOM   104  C  CB   . LYS A 1 8   ? 17.186  10.911  -14.269 1.00 39.49  ? 13  LYS C CB   1 
ATOM   105  C  CG   . LYS A 1 8   ? 17.873  11.921  -15.156 1.00 44.49  ? 13  LYS C CG   1 
ATOM   106  C  CD   . LYS A 1 8   ? 18.066  11.387  -16.565 1.00 51.44  ? 13  LYS C CD   1 
ATOM   107  C  CE   . LYS A 1 8   ? 19.061  12.181  -17.322 1.00 56.30  ? 13  LYS C CE   1 
ATOM   108  N  NZ   . LYS A 1 8   ? 19.176  11.707  -18.698 1.00 59.11  ? 13  LYS C NZ   1 
ATOM   109  H  H    . LYS A 1 8   ? 18.995  10.787  -12.638 1.00 46.26  ? 13  LYS C H    1 
ATOM   110  H  HA   . LYS A 1 8   ? 16.755  12.290  -12.786 1.00 42.98  ? 13  LYS C HA   1 
ATOM   111  H  HB2  . LYS A 1 8   ? 17.698  10.076  -14.298 1.00 47.44  ? 13  LYS C HB2  1 
ATOM   112  H  HB3  . LYS A 1 8   ? 16.297  10.729  -14.638 1.00 47.44  ? 13  LYS C HB3  1 
ATOM   113  H  HG2  . LYS A 1 8   ? 17.332  12.739  -15.187 1.00 53.43  ? 13  LYS C HG2  1 
ATOM   114  H  HG3  . LYS A 1 8   ? 18.747  12.145  -14.769 1.00 53.43  ? 13  LYS C HG3  1 
ATOM   115  H  HD2  . LYS A 1 8   ? 18.369  10.456  -16.515 1.00 61.77  ? 13  LYS C HD2  1 
ATOM   116  H  HD3  . LYS A 1 8   ? 17.208  11.409  -17.039 1.00 61.77  ? 13  LYS C HD3  1 
ATOM   117  H  HE2  . LYS A 1 8   ? 18.781  13.112  -17.331 1.00 67.60  ? 13  LYS C HE2  1 
ATOM   118  H  HE3  . LYS A 1 8   ? 19.929  12.111  -16.885 1.00 67.60  ? 13  LYS C HE3  1 
ATOM   119  H  HZ1  . LYS A 1 8   ? 19.791  12.203  -19.140 1.00 70.98  ? 13  LYS C HZ1  1 
ATOM   120  H  HZ2  . LYS A 1 8   ? 19.435  10.839  -18.692 1.00 70.98  ? 13  LYS C HZ2  1 
ATOM   121  H  HZ3  . LYS A 1 8   ? 18.374  11.779  -19.111 1.00 70.98  ? 13  LYS C HZ3  1 
ATOM   122  N  N    . LEU A 1 9   ? 16.386  9.317   -11.588 1.00 39.96  ? 14  LEU C N    1 
ATOM   123  C  CA   . LEU A 1 9   ? 15.482  8.453   -10.790 1.00 44.31  ? 14  LEU C CA   1 
ATOM   124  C  C    . LEU A 1 9   ? 15.200  9.170   -9.470  1.00 35.17  ? 14  LEU C C    1 
ATOM   125  O  O    . LEU A 1 9   ? 14.036  9.200   -9.055  1.00 38.35  ? 14  LEU C O    1 
ATOM   126  C  CB   . LEU A 1 9   ? 16.093  7.073   -10.549 1.00 42.79  ? 14  LEU C CB   1 
ATOM   127  C  CG   . LEU A 1 9   ? 15.454  6.251   -9.429  1.00 45.56  ? 14  LEU C CG   1 
ATOM   128  C  CD1  . LEU A 1 9   ? 14.023  5.909   -9.768  1.00 45.92  ? 14  LEU C CD1  1 
ATOM   129  C  CD2  . LEU A 1 9   ? 16.253  4.997   -9.168  1.00 48.35  ? 14  LEU C CD2  1 
ATOM   130  H  H    . LEU A 1 9   ? 17.217  9.000   -11.735 1.00 48.00  ? 14  LEU C H    1 
ATOM   131  H  HA   . LEU A 1 9   ? 14.631  8.351   -11.285 1.00 53.22  ? 14  LEU C HA   1 
ATOM   132  H  HB2  . LEU A 1 9   ? 16.030  6.558   -11.386 1.00 51.39  ? 14  LEU C HB2  1 
ATOM   133  H  HB3  . LEU A 1 9   ? 17.048  7.191   -10.341 1.00 51.39  ? 14  LEU C HB3  1 
ATOM   134  H  HG   . LEU A 1 9   ? 15.456  6.798   -8.603  1.00 54.72  ? 14  LEU C HG   1 
ATOM   135  H  HD11 . LEU A 1 9   ? 13.754  5.118   -9.272  1.00 55.15  ? 14  LEU C HD11 1 
ATOM   136  H  HD12 . LEU A 1 9   ? 13.446  6.654   -9.527  1.00 55.15  ? 14  LEU C HD12 1 
ATOM   137  H  HD13 . LEU A 1 9   ? 13.949  5.736   -10.721 1.00 55.15  ? 14  LEU C HD13 1 
ATOM   138  H  HD21 . LEU A 1 9   ? 15.899  4.545   -8.384  1.00 58.06  ? 14  LEU C HD21 1 
ATOM   139  H  HD22 . LEU A 1 9   ? 16.190  4.408   -9.938  1.00 58.06  ? 14  LEU C HD22 1 
ATOM   140  H  HD23 . LEU A 1 9   ? 17.183  5.232   -9.015  1.00 58.06  ? 14  LEU C HD23 1 
ATOM   141  N  N    . SER A 1 10  ? 16.233  9.736   -8.863  1.00 34.13  ? 15  SER C N    1 
ATOM   142  C  CA   . SER A 1 10  ? 16.108  10.420  -7.558  1.00 40.52  ? 15  SER C CA   1 
ATOM   143  C  C    . SER A 1 10  ? 15.176  11.631  -7.694  1.00 39.79  ? 15  SER C C    1 
ATOM   144  O  O    . SER A 1 10  ? 14.286  11.779  -6.849  1.00 38.94  ? 15  SER C O    1 
ATOM   145  C  CB   . SER A 1 10  ? 17.467  10.784  -7.044  1.00 39.84  ? 15  SER C CB   1 
ATOM   146  O  OG   . SER A 1 10  ? 18.224  9.630   -6.718  1.00 39.76  ? 15  SER C OG   1 
ATOM   147  H  H    . SER A 1 10  ? 17.055  9.743   -9.235  1.00 41.01  ? 15  SER C H    1 
ATOM   148  H  HA   . SER A 1 10  ? 15.696  9.786   -6.919  1.00 48.67  ? 15  SER C HA   1 
ATOM   149  H  HB2  . SER A 1 10  ? 17.939  11.299  -7.726  1.00 47.85  ? 15  SER C HB2  1 
ATOM   150  H  HB3  . SER A 1 10  ? 17.371  11.344  -6.252  1.00 47.85  ? 15  SER C HB3  1 
ATOM   151  H  HG   . SER A 1 10  ? 18.497  9.270   -7.431  1.00 47.75  ? 15  SER C HG   1 
ATOM   152  N  N    . PHE A 1 11  ? 15.333  12.413  -8.754  1.00 42.02  ? 16  PHE C N    1 
ATOM   153  C  CA   . PHE A 1 11  ? 14.508  13.619  -8.999  1.00 36.56  ? 16  PHE C CA   1 
ATOM   154  C  C    . PHE A 1 11  ? 13.083  13.210  -9.256  1.00 35.71  ? 16  PHE C C    1 
ATOM   155  O  O    . PHE A 1 11  ? 12.175  13.890  -8.775  1.00 37.89  ? 16  PHE C O    1 
ATOM   156  C  CB   . PHE A 1 11  ? 15.109  14.351  -10.198 1.00 37.50  ? 16  PHE C CB   1 
ATOM   157  C  CG   . PHE A 1 11  ? 14.298  15.529  -10.708 1.00 36.73  ? 16  PHE C CG   1 
ATOM   158  C  CD1  . PHE A 1 11  ? 13.202  15.335  -11.535 1.00 39.93  ? 16  PHE C CD1  1 
ATOM   159  C  CD2  . PHE A 1 11  ? 14.640  16.826  -10.361 1.00 44.89  ? 16  PHE C CD2  1 
ATOM   160  C  CE1  . PHE A 1 11  ? 12.464  16.410  -11.991 1.00 40.92  ? 16  PHE C CE1  1 
ATOM   161  C  CE2  . PHE A 1 11  ? 13.901  17.898  -10.825 1.00 41.54  ? 16  PHE C CE2  1 
ATOM   162  C  CZ   . PHE A 1 11  ? 12.816  17.688  -11.638 1.00 42.38  ? 16  PHE C CZ   1 
ATOM   163  H  H    . PHE A 1 11  ? 15.948  12.226  -9.387  1.00 50.46  ? 16  PHE C H    1 
ATOM   164  H  HA   . PHE A 1 11  ? 14.545  14.209  -8.202  1.00 43.92  ? 16  PHE C HA   1 
ATOM   165  H  HB2  . PHE A 1 11  ? 16.002  14.669  -9.945  1.00 45.05  ? 16  PHE C HB2  1 
ATOM   166  H  HB3  . PHE A 1 11  ? 15.221  13.704  -10.930 1.00 45.05  ? 16  PHE C HB3  1 
ATOM   167  H  HD1  . PHE A 1 11  ? 12.953  14.458  -11.780 1.00 47.96  ? 16  PHE C HD1  1 
ATOM   168  H  HD2  . PHE A 1 11  ? 15.385  16.975  -9.803  1.00 53.91  ? 16  PHE C HD2  1 
ATOM   169  H  HE1  . PHE A 1 11  ? 11.720  16.264  -12.551 1.00 49.15  ? 16  PHE C HE1  1 
ATOM   170  H  HE2  . PHE A 1 11  ? 14.143  18.776  -10.581 1.00 49.89  ? 16  PHE C HE2  1 
ATOM   171  H  HZ   . PHE A 1 11  ? 12.313  18.420  -11.954 1.00 50.90  ? 16  PHE C HZ   1 
ATOM   172  N  N    . SER A 1 12  ? 12.895  12.124  -9.995  1.00 38.81  ? 17  SER C N    1 
ATOM   173  C  CA   . SER A 1 12  ? 11.547  11.664  -10.384 1.00 33.03  ? 17  SER C CA   1 
ATOM   174  C  C    . SER A 1 12  ? 10.794  11.157  -9.151  1.00 39.92  ? 17  SER C C    1 
ATOM   175  O  O    . SER A 1 12  ? 9.586   11.422  -9.056  1.00 44.44  ? 17  SER C O    1 
ATOM   176  C  CB   . SER A 1 12  ? 11.656  10.640  -11.453 1.00 35.94  ? 17  SER C CB   1 
ATOM   177  O  OG   . SER A 1 12  ? 12.075  11.228  -12.674 1.00 43.12  ? 17  SER C OG   1 
ATOM   178  H  H    . SER A 1 12  ? 13.588  11.626  -10.286 1.00 46.62  ? 17  SER C H    1 
ATOM   179  H  HA   . SER A 1 12  ? 11.052  12.440  -10.749 1.00 39.68  ? 17  SER C HA   1 
ATOM   180  H  HB2  . SER A 1 12  ? 12.300  9.960   -11.181 1.00 43.17  ? 17  SER C HB2  1 
ATOM   181  H  HB3  . SER A 1 12  ? 10.789  10.211  -11.577 1.00 43.17  ? 17  SER C HB3  1 
ATOM   182  H  HG   . SER A 1 12  ? 12.872  11.498  -12.584 1.00 51.78  ? 17  SER C HG   1 
ATOM   183  N  N    . ILE A 1 13  ? 11.490  10.516  -8.218  1.00 37.79  ? 18  ILE C N    1 
ATOM   184  C  CA   . ILE A 1 13  ? 10.855  10.032  -6.959  1.00 37.98  ? 18  ILE C CA   1 
ATOM   185  C  C    . ILE A 1 13  ? 10.451  11.256  -6.125  1.00 41.23  ? 18  ILE C C    1 
ATOM   186  O  O    . ILE A 1 13  ? 9.315   11.282  -5.638  1.00 37.87  ? 18  ILE C O    1 
ATOM   187  C  CB   . ILE A 1 13  ? 11.793  9.077   -6.198  1.00 41.99  ? 18  ILE C CB   1 
ATOM   188  C  CG1  . ILE A 1 13  ? 11.971  7.754   -6.936  1.00 42.97  ? 18  ILE C CG1  1 
ATOM   189  C  CG2  . ILE A 1 13  ? 11.301  8.858   -4.768  1.00 47.31  ? 18  ILE C CG2  1 
ATOM   190  C  CD1  . ILE A 1 13  ? 13.253  7.021   -6.596  1.00 46.25  ? 18  ILE C CD1  1 
ATOM   191  H  H    . ILE A 1 13  ? 12.374  10.360  -8.308  1.00 45.39  ? 18  ILE C H    1 
ATOM   192  H  HA   . ILE A 1 13  ? 10.046  9.540   -7.195  1.00 45.62  ? 18  ILE C HA   1 
ATOM   193  H  HB   . ILE A 1 13  ? 12.670  9.507   -6.150  1.00 50.43  ? 18  ILE C HB   1 
ATOM   194  H  HG12 . ILE A 1 13  ? 11.212  7.173   -6.723  1.00 51.61  ? 18  ILE C HG12 1 
ATOM   195  H  HG13 . ILE A 1 13  ? 11.955  7.927   -7.900  1.00 51.61  ? 18  ILE C HG13 1 
ATOM   196  H  HG21 . ILE A 1 13  ? 11.657  8.021   -4.426  1.00 56.82  ? 18  ILE C HG21 1 
ATOM   197  H  HG22 . ILE A 1 13  ? 11.599  9.590   -4.203  1.00 56.82  ? 18  ILE C HG22 1 
ATOM   198  H  HG23 . ILE A 1 13  ? 10.330  8.820   -4.761  1.00 56.82  ? 18  ILE C HG23 1 
ATOM   199  H  HD11 . ILE A 1 13  ? 13.188  6.093   -6.892  1.00 55.54  ? 18  ILE C HD11 1 
ATOM   200  H  HD12 . ILE A 1 13  ? 14.003  7.452   -7.048  1.00 55.54  ? 18  ILE C HD12 1 
ATOM   201  H  HD13 . ILE A 1 13  ? 13.399  7.045   -5.631  1.00 55.54  ? 18  ILE C HD13 1 
ATOM   202  N  N    . GLY A 1 14  ? 11.334  12.243  -6.015  1.00 37.12  ? 19  GLY C N    1 
ATOM   203  C  CA   . GLY A 1 14  ? 11.060  13.458  -5.236  1.00 42.54  ? 19  GLY C CA   1 
ATOM   204  C  C    . GLY A 1 14  ? 9.874   14.207  -5.785  1.00 44.56  ? 19  GLY C C    1 
ATOM   205  O  O    . GLY A 1 14  ? 9.068   14.691  -4.981  1.00 43.32  ? 19  GLY C O    1 
ATOM   206  H  H    . GLY A 1 14  ? 12.136  12.206  -6.433  1.00 44.59  ? 19  GLY C H    1 
ATOM   207  H  HA2  . GLY A 1 14  ? 10.887  13.208  -4.299  1.00 51.09  ? 19  GLY C HA2  1 
ATOM   208  H  HA3  . GLY A 1 14  ? 11.855  14.039  -5.257  1.00 51.09  ? 19  GLY C HA3  1 
ATOM   209  N  N    . ALA A 1 15  ? 9.754   14.293  -7.103  1.00 43.73  ? 20  ALA C N    1 
ATOM   210  C  CA   . ALA A 1 15  ? 8.663   15.043  -7.752  1.00 38.04  ? 20  ALA C CA   1 
ATOM   211  C  C    . ALA A 1 15  ? 7.329   14.369  -7.445  1.00 41.42  ? 20  ALA C C    1 
ATOM   212  O  O    . ALA A 1 15  ? 6.362   15.081  -7.161  1.00 41.80  ? 20  ALA C O    1 
ATOM   213  C  CB   . ALA A 1 15  ? 8.930   15.110  -9.224  1.00 44.07  ? 20  ALA C CB   1 
ATOM   214  H  H    . ALA A 1 15  ? 10.321  13.888  -7.676  1.00 52.52  ? 20  ALA C H    1 
ATOM   215  H  HA   . ALA A 1 15  ? 8.645   15.964  -7.377  1.00 45.69  ? 20  ALA C HA   1 
ATOM   216  H  HB1  . ALA A 1 15  ? 8.157   15.483  -9.679  1.00 52.93  ? 20  ALA C HB1  1 
ATOM   217  H  HB2  . ALA A 1 15  ? 9.705   15.672  -9.389  1.00 52.93  ? 20  ALA C HB2  1 
ATOM   218  H  HB3  . ALA A 1 15  ? 9.104   14.216  -9.564  1.00 52.93  ? 20  ALA C HB3  1 
ATOM   219  N  N    . ASP A 1 16  ? 7.290   13.039  -7.485  1.00 44.40  ? 21  ASP C N    1 
ATOM   220  C  CA   . ASP A 1 16  ? 6.055   12.268  -7.207  1.00 37.67  ? 21  ASP C CA   1 
ATOM   221  C  C    . ASP A 1 16  ? 5.642   12.495  -5.758  1.00 48.01  ? 21  ASP C C    1 
ATOM   222  O  O    . ASP A 1 16  ? 4.447   12.727  -5.517  1.00 51.26  ? 21  ASP C O    1 
ATOM   223  C  CB   . ASP A 1 16  ? 6.253   10.795  -7.499  1.00 49.52  ? 21  ASP C CB   1 
ATOM   224  C  CG   . ASP A 1 16  ? 5.014   9.935   -7.308  1.00 64.87  ? 21  ASP C CG   1 
ATOM   225  O  OD1  . ASP A 1 16  ? 4.162   9.931   -8.216  1.00 72.17  ? 21  ASP C OD1  1 
ATOM   226  O  OD2  . ASP A 1 16  ? 4.909   9.292   -6.245  1.00 69.43  ? 21  ASP C OD2  1 
ATOM   227  H  H    . ASP A 1 16  ? 8.026   12.553  -7.676  1.00 53.32  ? 21  ASP C H    1 
ATOM   228  H  HA   . ASP A 1 16  ? 5.341   12.604  -7.793  1.00 45.24  ? 21  ASP C HA   1 
ATOM   229  H  HB2  . ASP A 1 16  ? 6.564   10.698  -8.422  1.00 59.47  ? 21  ASP C HB2  1 
ATOM   230  H  HB3  . ASP A 1 16  ? 6.957   10.459  -6.907  1.00 59.47  ? 21  ASP C HB3  1 
ATOM   231  N  N    . LEU A 1 17  ? 6.599   12.462  -4.837  1.00 47.28  ? 22  LEU C N    1 
ATOM   232  C  CA   . LEU A 1 17  ? 6.318   12.700  -3.402  1.00 49.01  ? 22  LEU C CA   1 
ATOM   233  C  C    . LEU A 1 17  ? 5.766   14.116  -3.235  1.00 45.22  ? 22  LEU C C    1 
ATOM   234  O  O    . LEU A 1 17  ? 4.781   14.270  -2.513  1.00 45.42  ? 22  LEU C O    1 
ATOM   235  C  CB   . LEU A 1 17  ? 7.597   12.508  -2.597  1.00 48.17  ? 22  LEU C CB   1 
ATOM   236  C  CG   . LEU A 1 17  ? 8.093   11.070  -2.457  1.00 58.87  ? 22  LEU C CG   1 
ATOM   237  C  CD1  . LEU A 1 17  ? 9.593   11.040  -2.289  1.00 63.42  ? 22  LEU C CD1  1 
ATOM   238  C  CD2  . LEU A 1 17  ? 7.409   10.397  -1.294  1.00 61.50  ? 22  LEU C CD2  1 
ATOM   239  H  H    . LEU A 1 17  ? 7.459   12.307  -5.057  1.00 56.77  ? 22  LEU C H    1 
ATOM   240  H  HA   . LEU A 1 17  ? 5.637   12.049  -3.100  1.00 58.85  ? 22  LEU C HA   1 
ATOM   241  H  HB2  . LEU A 1 17  ? 8.307   13.039  -3.023  1.00 57.85  ? 22  LEU C HB2  1 
ATOM   242  H  HB3  . LEU A 1 17  ? 7.448   12.875  -1.695  1.00 57.85  ? 22  LEU C HB3  1 
ATOM   243  H  HG   . LEU A 1 17  ? 7.860   10.577  -3.285  1.00 70.69  ? 22  LEU C HG   1 
ATOM   244  H  HD11 . LEU A 1 17  ? 9.917   10.135  -2.429  1.00 76.15  ? 22  LEU C HD11 1 
ATOM   245  H  HD12 . LEU A 1 17  ? 10.004  11.635  -2.939  1.00 76.15  ? 22  LEU C HD12 1 
ATOM   246  H  HD13 . LEU A 1 17  ? 9.823   11.332  -1.392  1.00 76.15  ? 22  LEU C HD13 1 
ATOM   247  H  HD21 . LEU A 1 17  ? 7.885   9.581   -1.067  1.00 73.85  ? 22  LEU C HD21 1 
ATOM   248  H  HD22 . LEU A 1 17  ? 7.409   10.996  -0.529  1.00 73.85  ? 22  LEU C HD22 1 
ATOM   249  H  HD23 . LEU A 1 17  ? 6.493   10.182  -1.537  1.00 73.85  ? 22  LEU C HD23 1 
ATOM   250  N  N    . GLY A 1 18  ? 6.372   15.092  -3.901  1.00 42.17  ? 23  GLY C N    1 
ATOM   251  C  CA   . GLY A 1 18  ? 5.968   16.496  -3.773  1.00 38.87  ? 23  GLY C CA   1 
ATOM   252  C  C    . GLY A 1 18  ? 4.546   16.689  -4.225  1.00 49.14  ? 23  GLY C C    1 
ATOM   253  O  O    . GLY A 1 18  ? 3.791   17.343  -3.501  1.00 41.18  ? 23  GLY C O    1 
ATOM   254  H  H    . GLY A 1 18  ? 7.052   14.920  -4.472  1.00 50.65  ? 23  GLY C H    1 
ATOM   255  H  HA2  . GLY A 1 18  ? 6.056   16.774  -2.832  1.00 46.68  ? 23  GLY C HA2  1 
ATOM   256  H  HA3  . GLY A 1 18  ? 6.568   17.057  -4.318  1.00 46.68  ? 23  GLY C HA3  1 
ATOM   257  N  N    . LYS A 1 19  ? 4.200   16.131  -5.376  1.00 45.34  ? 24  LYS C N    1 
ATOM   258  C  CA   . LYS A 1 19  ? 2.829   16.233  -5.920  1.00 52.15  ? 24  LYS C CA   1 
ATOM   259  C  C    . LYS A 1 19  ? 1.856   15.682  -4.883  1.00 48.95  ? 24  LYS C C    1 
ATOM   260  O  O    . LYS A 1 19  ? 0.913   16.389  -4.534  1.00 53.25  ? 24  LYS C O    1 
ATOM   261  C  CB   . LYS A 1 19  ? 2.745   15.436  -7.219  1.00 49.60  ? 24  LYS C CB   1 
ATOM   262  C  CG   . LYS A 1 19  ? 1.350   15.305  -7.789  1.00 68.69  ? 24  LYS C CG   1 
ATOM   263  C  CD   . LYS A 1 19  ? 1.328   15.333  -9.308  1.00 72.86  ? 24  LYS C CD   1 
ATOM   264  C  CE   . LYS A 1 19  ? 1.880   14.088  -9.903  1.00 78.87  ? 24  LYS C CE   1 
ATOM   265  N  NZ   . LYS A 1 19  ? 1.552   14.022  -11.328 1.00 85.71  ? 24  LYS C NZ   1 
ATOM   266  H  H    . LYS A 1 19  ? 4.788   15.650  -5.863  1.00 54.45  ? 24  LYS C H    1 
ATOM   267  H  HA   . LYS A 1 19  ? 2.621   17.185  -6.090  1.00 62.63  ? 24  LYS C HA   1 
ATOM   268  H  HB2  . LYS A 1 19  ? 3.315   15.866  -7.890  1.00 59.56  ? 24  LYS C HB2  1 
ATOM   269  H  HB3  . LYS A 1 19  ? 3.101   14.536  -7.060  1.00 59.56  ? 24  LYS C HB3  1 
ATOM   270  H  HG2  . LYS A 1 19  ? 0.958   14.461  -7.475  1.00 82.47  ? 24  LYS C HG2  1 
ATOM   271  H  HG3  . LYS A 1 19  ? 0.801   16.043  -7.448  1.00 82.47  ? 24  LYS C HG3  1 
ATOM   272  H  HD2  . LYS A 1 19  ? 0.403   15.451  -9.613  1.00 87.48  ? 24  LYS C HD2  1 
ATOM   273  H  HD3  . LYS A 1 19  ? 1.855   16.099  -9.621  1.00 87.48  ? 24  LYS C HD3  1 
ATOM   274  H  HE2  . LYS A 1 19  ? 2.847   14.070  -9.794  1.00 94.69  ? 24  LYS C HE2  1 
ATOM   275  H  HE3  . LYS A 1 19  ? 1.502   13.315  -9.449  1.00 94.69  ? 24  LYS C HE3  1 
ATOM   276  H  HZ1  . LYS A 1 19  ? 1.827   13.230  -11.670 1.00 102.89 ? 24  LYS C HZ1  1 
ATOM   277  H  HZ2  . LYS A 1 19  ? 0.657   14.103  -11.435 1.00 102.89 ? 24  LYS C HZ2  1 
ATOM   278  H  HZ3  . LYS A 1 19  ? 1.967   14.700  -11.763 1.00 102.89 ? 24  LYS C HZ3  1 
ATOM   279  N  N    . ASN A 1 20  ? 2.105   14.472  -4.408  1.00 52.79  ? 25  ASN C N    1 
ATOM   280  C  CA   . ASN A 1 20  ? 1.215   13.811  -3.426  1.00 52.15  ? 25  ASN C CA   1 
ATOM   281  C  C    . ASN A 1 20  ? 1.048   14.696  -2.182  1.00 56.58  ? 25  ASN C C    1 
ATOM   282  O  O    . ASN A 1 20  ? -0.098  14.907  -1.765  1.00 55.45  ? 25  ASN C O    1 
ATOM   283  C  CB   . ASN A 1 20  ? 1.758   12.423  -3.120  1.00 53.09  ? 25  ASN C CB   1 
ATOM   284  C  CG   . ASN A 1 20  ? 0.807   11.606  -2.283  1.00 72.92  ? 25  ASN C CG   1 
ATOM   285  O  OD1  . ASN A 1 20  ? 1.238   10.894  -1.370  1.00 70.18  ? 25  ASN C OD1  1 
ATOM   286  N  ND2  . ASN A 1 20  ? -0.482  11.687  -2.579  1.00 82.16  ? 25  ASN C ND2  1 
ATOM   287  H  H    . ASN A 1 20  ? 2.840   14.011  -4.653  1.00 63.39  ? 25  ASN C H    1 
ATOM   288  H  HA   . ASN A 1 20  ? 0.335   13.703  -3.848  1.00 62.63  ? 25  ASN C HA   1 
ATOM   289  H  HB2  . ASN A 1 20  ? 1.931   11.955  -3.961  1.00 63.75  ? 25  ASN C HB2  1 
ATOM   290  H  HB3  . ASN A 1 20  ? 2.608   12.512  -2.644  1.00 63.75  ? 25  ASN C HB3  1 
ATOM   291  H  HD21 . ASN A 1 20  ? -0.770  11.397  -3.365  1.00 98.63  ? 25  ASN C HD21 1 
ATOM   292  H  HD22 . ASN A 1 20  ? -1.050  12.046  -2.002  1.00 98.63  ? 25  ASN C HD22 1 
ATOM   293  N  N    . PHE A 1 21  ? 2.137   15.213  -1.624  1.00 47.96  ? 26  PHE C N    1 
ATOM   294  C  CA   . PHE A 1 21  ? 2.089   16.020  -0.382  1.00 47.70  ? 26  PHE C CA   1 
ATOM   295  C  C    . PHE A 1 21  ? 1.320   17.299  -0.632  1.00 54.93  ? 26  PHE C C    1 
ATOM   296  O  O    . PHE A 1 21  ? 0.552   17.702  0.243   1.00 51.88  ? 26  PHE C O    1 
ATOM   297  C  CB   . PHE A 1 21  ? 3.497   16.382  0.091   1.00 52.20  ? 26  PHE C CB   1 
ATOM   298  C  CG   . PHE A 1 21  ? 4.319   15.296  0.767   1.00 44.84  ? 26  PHE C CG   1 
ATOM   299  C  CD1  . PHE A 1 21  ? 3.787   14.513  1.781   1.00 51.17  ? 26  PHE C CD1  1 
ATOM   300  C  CD2  . PHE A 1 21  ? 5.644   15.093  0.408   1.00 46.74  ? 26  PHE C CD2  1 
ATOM   301  C  CE1  . PHE A 1 21  ? 4.554   13.539  2.397   1.00 51.52  ? 26  PHE C CE1  1 
ATOM   302  C  CE2  . PHE A 1 21  ? 6.406   14.119  1.028   1.00 48.81  ? 26  PHE C CE2  1 
ATOM   303  C  CZ   . PHE A 1 21  ? 5.860   13.345  2.020   1.00 44.87  ? 26  PHE C CZ   1 
ATOM   304  H  H    . PHE A 1 21  ? 2.953   15.104  -1.993  1.00 57.59  ? 26  PHE C H    1 
ATOM   305  H  HA   . PHE A 1 21  ? 1.629   15.498  0.328   1.00 57.28  ? 26  PHE C HA   1 
ATOM   306  H  HB2  . PHE A 1 21  ? 4.000   16.705  -0.690  1.00 62.69  ? 26  PHE C HB2  1 
ATOM   307  H  HB3  . PHE A 1 21  ? 3.418   17.138  0.712   1.00 62.69  ? 26  PHE C HB3  1 
ATOM   308  H  HD1  . PHE A 1 21  ? 2.892   14.642  2.046   1.00 61.45  ? 26  PHE C HD1  1 
ATOM   309  H  HD2  . PHE A 1 21  ? 6.025   15.620  -0.277  1.00 56.13  ? 26  PHE C HD2  1 
ATOM   310  H  HE1  . PHE A 1 21  ? 4.177   13.010  3.080   1.00 61.87  ? 26  PHE C HE1  1 
ATOM   311  H  HE2  . PHE A 1 21  ? 7.302   13.984  0.764   1.00 58.62  ? 26  PHE C HE2  1 
ATOM   312  H  HZ   . PHE A 1 21  ? 6.380   12.680  2.441   1.00 53.88  ? 26  PHE C HZ   1 
ATOM   313  N  N    . LYS A 1 22  ? 1.513   17.916  -1.791  1.00 55.24  ? 27  LYS C N    1 
ATOM   314  C  CA   . LYS A 1 22  ? 0.857   19.203  -2.126  1.00 59.89  ? 27  LYS C CA   1 
ATOM   315  C  C    . LYS A 1 22  ? -0.638  18.959  -2.317  1.00 58.70  ? 27  LYS C C    1 
ATOM   316  O  O    . LYS A 1 22  ? -1.424  19.823  -1.902  1.00 57.76  ? 27  LYS C O    1 
ATOM   317  C  CB   . LYS A 1 22  ? 1.461   19.803  -3.397  1.00 57.22  ? 27  LYS C CB   1 
ATOM   318  C  CG   . LYS A 1 22  ? 1.085   21.242  -3.677  1.00 66.15  ? 27  LYS C CG   1 
ATOM   319  C  CD   . LYS A 1 22  ? 1.493   22.192  -2.562  1.00 70.29  ? 27  LYS C CD   1 
ATOM   320  C  CE   . LYS A 1 22  ? 1.330   23.614  -2.948  1.00 70.46  ? 27  LYS C CE   1 
ATOM   321  N  NZ   . LYS A 1 22  ? 1.602   24.474  -1.798  1.00 78.98  ? 27  LYS C NZ   1 
ATOM   322  H  H    . LYS A 1 22  ? 2.041   17.563  -2.430  1.00 66.33  ? 27  LYS C H    1 
ATOM   323  H  HA   . LYS A 1 22  ? 0.985   19.823  -1.368  1.00 71.92  ? 27  LYS C HA   1 
ATOM   324  H  HB2  . LYS A 1 22  ? 2.437   19.747  -3.332  1.00 68.71  ? 27  LYS C HB2  1 
ATOM   325  H  HB3  . LYS A 1 22  ? 1.182   19.255  -4.161  1.00 68.71  ? 27  LYS C HB3  1 
ATOM   326  H  HG2  . LYS A 1 22  ? 1.517   21.523  -4.511  1.00 79.42  ? 27  LYS C HG2  1 
ATOM   327  H  HG3  . LYS A 1 22  ? 0.114   21.296  -3.805  1.00 79.42  ? 27  LYS C HG3  1 
ATOM   328  H  HD2  . LYS A 1 22  ? 0.945   22.012  -1.768  1.00 84.39  ? 27  LYS C HD2  1 
ATOM   329  H  HD3  . LYS A 1 22  ? 2.432   22.028  -2.329  1.00 84.39  ? 27  LYS C HD3  1 
ATOM   330  H  HE2  . LYS A 1 22  ? 1.945   23.833  -3.670  1.00 84.60  ? 27  LYS C HE2  1 
ATOM   331  H  HE3  . LYS A 1 22  ? 0.420   23.766  -3.257  1.00 84.60  ? 27  LYS C HE3  1 
ATOM   332  H  HZ1  . LYS A 1 22  ? 1.443   25.338  -2.015  1.00 94.82  ? 27  LYS C HZ1  1 
ATOM   333  H  HZ2  . LYS A 1 22  ? 1.066   24.232  -1.109  1.00 94.82  ? 27  LYS C HZ2  1 
ATOM   334  H  HZ3  . LYS A 1 22  ? 2.467   24.378  -1.549  1.00 94.82  ? 27  LYS C HZ3  1 
ATOM   335  N  N    . ASN A 1 23  ? -0.998  17.813  -2.887  1.00 57.21  ? 28  ASN C N    1 
ATOM   336  C  CA   . ASN A 1 23  ? -2.417  17.452  -3.127  1.00 54.34  ? 28  ASN C CA   1 
ATOM   337  C  C    . ASN A 1 23  ? -3.101  17.169  -1.790  1.00 58.23  ? 28  ASN C C    1 
ATOM   338  O  O    . ASN A 1 23  ? -4.321  17.384  -1.719  1.00 55.96  ? 28  ASN C O    1 
ATOM   339  C  CB   . ASN A 1 23  ? -2.522  16.272  -4.079  1.00 53.84  ? 28  ASN C CB   1 
ATOM   340  C  CG   . ASN A 1 23  ? -2.004  16.575  -5.466  1.00 64.30  ? 28  ASN C CG   1 
ATOM   341  O  OD1  . ASN A 1 23  ? -2.020  17.726  -5.913  1.00 67.09  ? 28  ASN C OD1  1 
ATOM   342  N  ND2  . ASN A 1 23  ? -1.529  15.553  -6.161  1.00 63.71  ? 28  ASN C ND2  1 
ATOM   343  H  H    . ASN A 1 23  ? -0.386  17.198  -3.133  1.00 68.70  ? 28  ASN C H    1 
ATOM   344  H  HA   . ASN A 1 23  ? -2.865  18.218  -3.546  1.00 65.25  ? 28  ASN C HA   1 
ATOM   345  H  HB2  . ASN A 1 23  ? -2.012  15.523  -3.710  1.00 64.65  ? 28  ASN C HB2  1 
ATOM   346  H  HB3  . ASN A 1 23  ? -3.457  15.996  -4.142  1.00 64.65  ? 28  ASN C HB3  1 
ATOM   347  H  HD21 . ASN A 1 23  ? -0.974  14.980  -5.771  1.00 76.49  ? 28  ASN C HD21 1 
ATOM   348  H  HD22 . ASN A 1 23  ? -1.754  15.449  -7.011  1.00 76.49  ? 28  ASN C HD22 1 
ATOM   349  N  N    . GLN A 1 24  ? -2.352  16.727  -0.776  1.00 57.76  ? 29  GLN C N    1 
ATOM   350  C  CA   . GLN A 1 24  ? -2.917  16.367  0.548   1.00 45.70  ? 29  GLN C CA   1 
ATOM   351  C  C    . GLN A 1 24  ? -2.768  17.527  1.543   1.00 52.97  ? 29  GLN C C    1 
ATOM   352  O  O    . GLN A 1 24  ? -3.323  17.421  2.646   1.00 56.22  ? 29  GLN C O    1 
ATOM   353  C  CB   . GLN A 1 24  ? -2.207  15.119  1.052   1.00 50.81  ? 29  GLN C CB   1 
ATOM   354  C  CG   . GLN A 1 24  ? -2.574  13.845  0.309   1.00 52.98  ? 29  GLN C CG   1 
ATOM   355  C  CD   . GLN A 1 24  ? -1.878  12.642  0.896   1.00 64.37  ? 29  GLN C CD   1 
ATOM   356  O  OE1  . GLN A 1 24  ? -2.464  11.865  1.654   1.00 71.33  ? 29  GLN C OE1  1 
ATOM   357  N  NE2  . GLN A 1 24  ? -0.601  12.504  0.576   1.00 63.74  ? 29  GLN C NE2  1 
ATOM   358  H  H    . GLN A 1 24  ? -1.462  16.612  -0.865  1.00 69.36  ? 29  GLN C H    1 
ATOM   359  H  HA   . GLN A 1 24  ? -3.877  16.159  0.441   1.00 54.89  ? 29  GLN C HA   1 
ATOM   360  H  HB2  . GLN A 1 24  ? -1.241  15.263  0.970   1.00 61.02  ? 29  GLN C HB2  1 
ATOM   361  H  HB3  . GLN A 1 24  ? -2.409  15.000  2.002   1.00 61.02  ? 29  GLN C HB3  1 
ATOM   362  H  HG2  . GLN A 1 24  ? -3.543  13.712  0.351   1.00 63.62  ? 29  GLN C HG2  1 
ATOM   363  H  HG3  . GLN A 1 24  ? -2.321  13.933  -0.634  1.00 63.62  ? 29  GLN C HG3  1 
ATOM   364  H  HE21 . GLN A 1 24  ? -0.129  13.217  0.332   1.00 76.54  ? 29  GLN C HE21 1 
ATOM   365  H  HE22 . GLN A 1 24  ? -0.222  11.704  0.596   1.00 76.54  ? 29  GLN C HE22 1 
ATOM   366  N  N    . GLY A 1 25  ? -2.043  18.579  1.180   1.00 57.83  ? 30  GLY C N    1 
ATOM   367  C  CA   . GLY A 1 25  ? -1.843  19.749  2.055   1.00 56.09  ? 30  GLY C CA   1 
ATOM   368  C  C    . GLY A 1 25  ? -0.822  19.497  3.145   1.00 57.94  ? 30  GLY C C    1 
ATOM   369  O  O    . GLY A 1 25  ? -0.893  20.192  4.172   1.00 53.55  ? 30  GLY C O    1 
ATOM   370  H  H    . GLY A 1 25  ? -1.624  18.609  0.379   1.00 69.44  ? 30  GLY C H    1 
ATOM   371  H  HA2  . GLY A 1 25  ? -1.545  20.508  1.503   1.00 67.35  ? 30  GLY C HA2  1 
ATOM   372  H  HA3  . GLY A 1 25  ? -2.704  19.995  2.464   1.00 67.35  ? 30  GLY C HA3  1 
ATOM   373  N  N    . ILE A 1 26  ? 0.089   18.548  2.945   1.00 52.35  ? 31  ILE C N    1 
ATOM   374  C  CA   . ILE A 1 26  ? 1.163   18.219  3.927   1.00 54.99  ? 31  ILE C CA   1 
ATOM   375  C  C    . ILE A 1 26  ? 2.335   19.194  3.715   1.00 49.32  ? 31  ILE C C    1 
ATOM   376  O  O    . ILE A 1 26  ? 2.905   19.179  2.615   1.00 48.03  ? 31  ILE C O    1 
ATOM   377  C  CB   . ILE A 1 26  ? 1.569   16.742  3.788   1.00 53.12  ? 31  ILE C CB   1 
ATOM   378  C  CG1  . ILE A 1 26  ? 0.412   15.800  4.109   1.00 45.83  ? 31  ILE C CG1  1 
ATOM   379  C  CG2  . ILE A 1 26  ? 2.792   16.422  4.643   1.00 53.67  ? 31  ILE C CG2  1 
ATOM   380  C  CD1  . ILE A 1 26  ? 0.403   14.539  3.270   1.00 46.61  ? 31  ILE C CD1  1 
ATOM   381  H  H    . ILE A 1 26  ? 0.090   18.046  2.195   1.00 62.87  ? 31  ILE C H    1 
ATOM   382  H  HA   . ILE A 1 26  ? 0.810   18.351  4.826   1.00 66.03  ? 31  ILE C HA   1 
ATOM   383  H  HB   . ILE A 1 26  ? 1.814   16.593  2.853   1.00 63.79  ? 31  ILE C HB   1 
ATOM   384  H  HG12 . ILE A 1 26  ? 0.466   15.548  5.053   1.00 55.04  ? 31  ILE C HG12 1 
ATOM   385  H  HG13 . ILE A 1 26  ? -0.433  16.272  3.972   1.00 55.04  ? 31  ILE C HG13 1 
ATOM   386  H  HG21 . ILE A 1 26  ? 2.726   15.509  4.972   1.00 64.44  ? 31  ILE C HG21 1 
ATOM   387  H  HG22 . ILE A 1 26  ? 3.595   16.512  4.106   1.00 64.44  ? 31  ILE C HG22 1 
ATOM   388  H  HG23 . ILE A 1 26  ? 2.834   17.033  5.397   1.00 64.44  ? 31  ILE C HG23 1 
ATOM   389  H  HD11 . ILE A 1 26  ? -0.446  14.071  3.388   1.00 55.98  ? 31  ILE C HD11 1 
ATOM   390  H  HD12 . ILE A 1 26  ? 0.514   14.778  2.329   1.00 55.98  ? 31  ILE C HD12 1 
ATOM   391  H  HD13 . ILE A 1 26  ? 1.136   13.957  3.546   1.00 55.98  ? 31  ILE C HD13 1 
ATOM   392  N  N    . ASP A 1 27  ? 2.650   20.022  4.712   1.00 45.34  ? 32  ASP C N    1 
ATOM   393  C  CA   . ASP A 1 27  ? 3.770   21.002  4.641   1.00 50.71  ? 32  ASP C CA   1 
ATOM   394  C  C    . ASP A 1 27  ? 5.055   20.308  5.084   1.00 51.10  ? 32  ASP C C    1 
ATOM   395  O  O    . ASP A 1 27  ? 5.059   19.770  6.201   1.00 53.07  ? 32  ASP C O    1 
ATOM   396  C  CB   . ASP A 1 27  ? 3.493   22.238  5.475   1.00 45.54  ? 32  ASP C CB   1 
ATOM   397  C  CG   . ASP A 1 27  ? 4.432   23.418  5.270   1.00 56.78  ? 32  ASP C CG   1 
ATOM   398  O  OD1  . ASP A 1 27  ? 5.242   23.377  4.325   1.00 63.24  ? 32  ASP C OD1  1 
ATOM   399  O  OD2  . ASP A 1 27  ? 4.340   24.378  6.059   1.00 66.35  ? 32  ASP C OD2  1 
ATOM   400  H  H    . ASP A 1 27  ? 2.189   20.017  5.487   1.00 54.45  ? 32  ASP C H    1 
ATOM   401  H  HA   . ASP A 1 27  ? 3.874   21.285  3.707   1.00 60.89  ? 32  ASP C HA   1 
ATOM   402  H  HB2  . ASP A 1 27  ? 2.583   22.539  5.273   1.00 54.69  ? 32  ASP C HB2  1 
ATOM   403  H  HB3  . ASP A 1 27  ? 3.519   21.989  6.422   1.00 54.69  ? 32  ASP C HB3  1 
ATOM   404  N  N    . VAL A 1 28  ? 6.098   20.343  4.261   1.00 48.77  ? 33  VAL C N    1 
ATOM   405  C  CA   . VAL A 1 28  ? 7.365   19.613  4.538   1.00 48.73  ? 33  VAL C CA   1 
ATOM   406  C  C    . VAL A 1 28  ? 8.576   20.448  4.115   1.00 48.24  ? 33  VAL C C    1 
ATOM   407  O  O    . VAL A 1 28  ? 8.442   21.172  3.121   1.00 54.16  ? 33  VAL C O    1 
ATOM   408  C  CB   . VAL A 1 28  ? 7.303   18.286  3.761   1.00 53.36  ? 33  VAL C CB   1 
ATOM   409  C  CG1  . VAL A 1 28  ? 8.672   17.647  3.581   1.00 59.17  ? 33  VAL C CG1  1 
ATOM   410  C  CG2  . VAL A 1 28  ? 6.332   17.302  4.392   1.00 55.28  ? 33  VAL C CG2  1 
ATOM   411  H  H    . VAL A 1 28  ? 6.080   20.814  3.493   1.00 58.57  ? 33  VAL C H    1 
ATOM   412  H  HA   . VAL A 1 28  ? 7.430   19.421  5.491   1.00 58.52  ? 33  VAL C HA   1 
ATOM   413  H  HB   . VAL A 1 28  ? 6.958   18.499  2.863   1.00 64.08  ? 33  VAL C HB   1 
ATOM   414  H  HG11 . VAL A 1 28  ? 8.557   16.725  3.307   1.00 71.05  ? 33  VAL C HG11 1 
ATOM   415  H  HG12 . VAL A 1 28  ? 9.173   18.125  2.899   1.00 71.05  ? 33  VAL C HG12 1 
ATOM   416  H  HG13 . VAL A 1 28  ? 9.159   17.675  4.422   1.00 71.05  ? 33  VAL C HG13 1 
ATOM   417  H  HG21 . VAL A 1 28  ? 6.452   16.425  3.991   1.00 66.38  ? 33  VAL C HG21 1 
ATOM   418  H  HG22 . VAL A 1 28  ? 6.501   17.248  5.347   1.00 66.38  ? 33  VAL C HG22 1 
ATOM   419  H  HG23 . VAL A 1 28  ? 5.422   17.604  4.241   1.00 66.38  ? 33  VAL C HG23 1 
ATOM   420  N  N    . ASN A 1 29  ? 9.693   20.348  4.837   1.00 49.11  ? 34  ASN C N    1 
ATOM   421  C  CA   . ASN A 1 29  ? 10.965  21.018  4.460   1.00 43.42  ? 34  ASN C CA   1 
ATOM   422  C  C    . ASN A 1 29  ? 11.815  20.003  3.692   1.00 42.81  ? 34  ASN C C    1 
ATOM   423  O  O    . ASN A 1 29  ? 12.307  19.059  4.323   1.00 40.93  ? 34  ASN C O    1 
ATOM   424  C  CB   . ASN A 1 29  ? 11.739  21.543  5.656   1.00 44.35  ? 34  ASN C CB   1 
ATOM   425  C  CG   . ASN A 1 29  ? 13.098  22.071  5.273   1.00 51.89  ? 34  ASN C CG   1 
ATOM   426  O  OD1  . ASN A 1 29  ? 13.323  22.464  4.124   1.00 56.26  ? 34  ASN C OD1  1 
ATOM   427  N  ND2  . ASN A 1 29  ? 14.020  22.089  6.220   1.00 55.82  ? 34  ASN C ND2  1 
ATOM   428  H  H    . ASN A 1 29  ? 9.721   19.855  5.592   1.00 58.98  ? 34  ASN C H    1 
ATOM   429  H  HA   . ASN A 1 29  ? 10.757  21.785  3.895   1.00 52.15  ? 34  ASN C HA   1 
ATOM   430  H  HB2  . ASN A 1 29  ? 11.225  22.257  6.080   1.00 53.26  ? 34  ASN C HB2  1 
ATOM   431  H  HB3  . ASN A 1 29  ? 11.849  20.822  6.308   1.00 53.26  ? 34  ASN C HB3  1 
ATOM   432  H  HD21 . ASN A 1 29  ? 14.873  21.968  6.005   1.00 67.03  ? 34  ASN C HD21 1 
ATOM   433  H  HD22 . ASN A 1 29  ? 13.782  22.207  7.065   1.00 67.03  ? 34  ASN C HD22 1 
ATOM   434  N  N    . PRO A 1 30  ? 12.009  20.142  2.368   1.00 43.96  ? 35  PRO C N    1 
ATOM   435  C  CA   . PRO A 1 30  ? 12.765  19.153  1.621   1.00 45.70  ? 35  PRO C CA   1 
ATOM   436  C  C    . PRO A 1 30  ? 14.209  18.969  2.074   1.00 48.38  ? 35  PRO C C    1 
ATOM   437  O  O    . PRO A 1 30  ? 14.711  17.846  1.998   1.00 47.94  ? 35  PRO C O    1 
ATOM   438  C  CB   . PRO A 1 30  ? 12.675  19.732  0.215   1.00 51.23  ? 35  PRO C CB   1 
ATOM   439  C  CG   . PRO A 1 30  ? 11.404  20.516  0.220   1.00 49.10  ? 35  PRO C CG   1 
ATOM   440  C  CD   . PRO A 1 30  ? 11.518  21.220  1.537   1.00 51.97  ? 35  PRO C CD   1 
ATOM   441  H  HA   . PRO A 1 30  ? 12.288  18.288  1.656   1.00 54.89  ? 35  PRO C HA   1 
ATOM   442  H  HB2  . PRO A 1 30  ? 13.446  20.316  0.028   1.00 61.52  ? 35  PRO C HB2  1 
ATOM   443  H  HB3  . PRO A 1 30  ? 12.644  19.015  -0.458  1.00 61.52  ? 35  PRO C HB3  1 
ATOM   444  H  HG2  . PRO A 1 30  ? 11.367  21.150  -0.525  1.00 58.96  ? 35  PRO C HG2  1 
ATOM   445  H  HG3  . PRO A 1 30  ? 10.619  19.930  0.196   1.00 58.96  ? 35  PRO C HG3  1 
ATOM   446  H  HD2  . PRO A 1 30  ? 12.161  21.961  1.493   1.00 62.41  ? 35  PRO C HD2  1 
ATOM   447  H  HD3  . PRO A 1 30  ? 10.648  21.549  1.837   1.00 62.41  ? 35  PRO C HD3  1 
ATOM   448  N  N    . GLU A 1 31  ? 14.855  20.031  2.546   1.00 48.93  ? 36  GLU C N    1 
ATOM   449  C  CA   . GLU A 1 31  ? 16.275  19.982  2.968   1.00 43.93  ? 36  GLU C CA   1 
ATOM   450  C  C    . GLU A 1 31  ? 16.430  19.114  4.216   1.00 45.77  ? 36  GLU C C    1 
ATOM   451  O  O    . GLU A 1 31  ? 17.397  18.348  4.280   1.00 48.70  ? 36  GLU C O    1 
ATOM   452  C  CB   . GLU A 1 31  ? 16.789  21.386  3.257   1.00 51.21  ? 36  GLU C CB   1 
ATOM   453  C  CG   . GLU A 1 31  ? 18.264  21.569  2.916   1.00 75.51  ? 36  GLU C CG   1 
ATOM   454  C  CD   . GLU A 1 31  ? 18.600  21.776  1.446   1.00 97.48  ? 36  GLU C CD   1 
ATOM   455  O  OE1  . GLU A 1 31  ? 19.809  21.761  1.129   1.00 88.50  ? 36  GLU C OE1  1 
ATOM   456  O  OE2  . GLU A 1 31  ? 17.680  21.952  0.618   1.00 95.38  ? 36  GLU C OE2  1 
ATOM   457  H  H    . GLU A 1 31  ? 14.443  20.828  2.638   1.00 58.76  ? 36  GLU C H    1 
ATOM   458  H  HA   . GLU A 1 31  ? 16.808  19.584  2.235   1.00 52.76  ? 36  GLU C HA   1 
ATOM   459  H  HB2  . GLU A 1 31  ? 16.247  22.030  2.758   1.00 61.50  ? 36  GLU C HB2  1 
ATOM   460  H  HB3  . GLU A 1 31  ? 16.665  21.571  4.210   1.00 61.50  ? 36  GLU C HB3  1 
ATOM   461  H  HG2  . GLU A 1 31  ? 18.607  22.339  3.417   1.00 90.65  ? 36  GLU C HG2  1 
ATOM   462  H  HG3  . GLU A 1 31  ? 18.755  20.781  3.230   1.00 90.65  ? 36  GLU C HG3  1 
ATOM   463  N  N    . ALA A 1 32  ? 15.514  19.226  5.162   1.00 38.09  ? 37  ALA C N    1 
ATOM   464  C  CA   . ALA A 1 32  ? 15.561  18.441  6.408   1.00 39.76  ? 37  ALA C CA   1 
ATOM   465  C  C    . ALA A 1 32  ? 15.261  16.974  6.098   1.00 41.85  ? 37  ALA C C    1 
ATOM   466  O  O    . ALA A 1 32  ? 15.823  16.101  6.764   1.00 38.53  ? 37  ALA C O    1 
ATOM   467  C  CB   . ALA A 1 32  ? 14.591  19.032  7.389   1.00 41.00  ? 37  ALA C CB   1 
ATOM   468  H  H    . ALA A 1 32  ? 14.797  19.767  5.088   1.00 45.75  ? 37  ALA C H    1 
ATOM   469  H  HA   . ALA A 1 32  ? 16.482  18.500  6.783   1.00 47.76  ? 37  ALA C HA   1 
ATOM   470  H  HB1  . ALA A 1 32  ? 14.390  18.381  8.082   1.00 49.25  ? 37  ALA C HB1  1 
ATOM   471  H  HB2  . ALA A 1 32  ? 14.978  19.826  7.793   1.00 49.25  ? 37  ALA C HB2  1 
ATOM   472  H  HB3  . ALA A 1 32  ? 13.770  19.274  6.928   1.00 49.25  ? 37  ALA C HB3  1 
ATOM   473  N  N    . MET A 1 33  ? 14.416  16.717  5.107   1.00 37.02  ? 38  MET C N    1 
ATOM   474  C  CA   . MET A 1 33  ? 14.101  15.334  4.685   1.00 43.73  ? 38  MET C CA   1 
ATOM   475  C  C    . MET A 1 33  ? 15.365  14.719  4.084   1.00 43.10  ? 38  MET C C    1 
ATOM   476  O  O    . MET A 1 33  ? 15.654  13.563  4.396   1.00 42.42  ? 38  MET C O    1 
ATOM   477  C  CB   . MET A 1 33  ? 12.976  15.314  3.651   1.00 45.51  ? 38  MET C CB   1 
ATOM   478  C  CG   . MET A 1 33  ? 12.443  13.937  3.344   1.00 47.39  ? 38  MET C CG   1 
ATOM   479  S  SD   . MET A 1 33  ? 11.193  13.968  2.047   1.00 59.69  ? 38  MET C SD   1 
ATOM   480  C  CE   . MET A 1 33  ? 9.727   14.318  3.023   1.00 59.59  ? 38  MET C CE   1 
ATOM   481  H  H    . MET A 1 33  ? 14.007  17.378  4.649   1.00 44.47  ? 38  MET C H    1 
ATOM   482  H  HA   . MET A 1 33  ? 13.833  14.812  5.480   1.00 52.52  ? 38  MET C HA   1 
ATOM   483  H  HB2  . MET A 1 33  ? 12.241  15.873  3.981   1.00 54.66  ? 38  MET C HB2  1 
ATOM   484  H  HB3  . MET A 1 33  ? 13.308  15.718  2.822   1.00 54.66  ? 38  MET C HB3  1 
ATOM   485  H  HG2  . MET A 1 33  ? 13.177  13.358  3.060   1.00 56.91  ? 38  MET C HG2  1 
ATOM   486  H  HG3  . MET A 1 33  ? 12.051  13.554  4.152   1.00 56.91  ? 38  MET C HG3  1 
ATOM   487  H  HE1  . MET A 1 33  ? 9.034   14.690  2.447   1.00 71.55  ? 38  MET C HE1  1 
ATOM   488  H  HE2  . MET A 1 33  ? 9.404   13.494  3.431   1.00 71.55  ? 38  MET C HE2  1 
ATOM   489  H  HE3  . MET A 1 33  ? 9.950   14.962  3.721   1.00 71.55  ? 38  MET C HE3  1 
ATOM   490  N  N    . ALA A 1 34  ? 16.091  15.480  3.273   1.00 40.69  ? 39  ALA C N    1 
ATOM   491  C  CA   . ALA A 1 34  ? 17.334  15.003  2.631   1.00 46.85  ? 39  ALA C CA   1 
ATOM   492  C  C    . ALA A 1 34  ? 18.367  14.657  3.699   1.00 44.31  ? 39  ALA C C    1 
ATOM   493  O  O    . ALA A 1 34  ? 19.054  13.649  3.543   1.00 41.35  ? 39  ALA C O    1 
ATOM   494  C  CB   . ALA A 1 34  ? 17.852  16.043  1.687   1.00 47.47  ? 39  ALA C CB   1 
ATOM   495  H  H    . ALA A 1 34  ? 15.877  16.335  3.080   1.00 48.87  ? 39  ALA C H    1 
ATOM   496  H  HA   . ALA A 1 34  ? 17.123  14.174  2.121   1.00 56.26  ? 39  ALA C HA   1 
ATOM   497  H  HB1  . ALA A 1 34  ? 18.521  15.650  1.103   1.00 57.01  ? 39  ALA C HB1  1 
ATOM   498  H  HB2  . ALA A 1 34  ? 17.120  16.391  1.152   1.00 57.01  ? 39  ALA C HB2  1 
ATOM   499  H  HB3  . ALA A 1 34  ? 18.253  16.770  2.192   1.00 57.01  ? 39  ALA C HB3  1 
ATOM   500  N  N    . LYS A 1 35  ? 18.448  15.460  4.754   1.00 39.96  ? 40  LYS C N    1 
ATOM   501  C  CA   . LYS A 1 35  ? 19.419  15.216  5.847   1.00 48.65  ? 40  LYS C CA   1 
ATOM   502  C  C    . LYS A 1 35  ? 19.119  13.854  6.486   1.00 44.90  ? 40  LYS C C    1 
ATOM   503  O  O    . LYS A 1 35  ? 20.054  13.069  6.635   1.00 50.23  ? 40  LYS C O    1 
ATOM   504  C  CB   . LYS A 1 35  ? 19.356  16.361  6.859   1.00 48.64  ? 40  LYS C CB   1 
ATOM   505  C  CG   . LYS A 1 35  ? 20.144  16.175  8.141   1.00 47.20  ? 40  LYS C CG   1 
ATOM   506  C  CD   . LYS A 1 35  ? 21.648  16.149  7.928   1.00 61.66  ? 40  LYS C CD   1 
ATOM   507  C  CE   . LYS A 1 35  ? 22.384  16.364  9.206   1.00 61.21  ? 40  LYS C CE   1 
ATOM   508  N  NZ   . LYS A 1 35  ? 23.722  15.780  9.136   1.00 69.69  ? 40  LYS C NZ   1 
ATOM   509  H  H    . LYS A 1 35  ? 17.910  16.178  4.845   1.00 47.99  ? 40  LYS C H    1 
ATOM   510  H  HA   . LYS A 1 35  ? 20.327  15.186  5.455   1.00 58.42  ? 40  LYS C HA   1 
ATOM   511  H  HB2  . LYS A 1 35  ? 19.677  17.175  6.419   1.00 58.42  ? 40  LYS C HB2  1 
ATOM   512  H  HB3  . LYS A 1 35  ? 18.417  16.508  7.097   1.00 58.42  ? 40  LYS C HB3  1 
ATOM   513  H  HG2  . LYS A 1 35  ? 19.923  16.911  8.751   1.00 56.68  ? 40  LYS C HG2  1 
ATOM   514  H  HG3  . LYS A 1 35  ? 19.865  15.339  8.571   1.00 56.68  ? 40  LYS C HG3  1 
ATOM   515  H  HD2  . LYS A 1 35  ? 21.908  15.284  7.546   1.00 74.04  ? 40  LYS C HD2  1 
ATOM   516  H  HD3  . LYS A 1 35  ? 21.895  16.853  7.291   1.00 74.04  ? 40  LYS C HD3  1 
ATOM   517  H  HE2  . LYS A 1 35  ? 22.460  17.318  9.382   1.00 73.50  ? 40  LYS C HE2  1 
ATOM   518  H  HE3  . LYS A 1 35  ? 21.891  15.956  9.939   1.00 73.50  ? 40  LYS C HE3  1 
ATOM   519  H  HZ1  . LYS A 1 35  ? 24.179  15.963  9.896   1.00 83.68  ? 40  LYS C HZ1  1 
ATOM   520  H  HZ2  . LYS A 1 35  ? 23.655  14.884  9.034   1.00 83.68  ? 40  LYS C HZ2  1 
ATOM   521  H  HZ3  . LYS A 1 35  ? 24.163  16.127  8.426   1.00 83.68  ? 40  LYS C HZ3  1 
ATOM   522  N  N    . GLY A 1 36  ? 17.862  13.591  6.828   1.00 47.91  ? 41  GLY C N    1 
ATOM   523  C  CA   . GLY A 1 36  ? 17.468  12.329  7.476   1.00 37.65  ? 41  GLY C CA   1 
ATOM   524  C  C    . GLY A 1 36  ? 17.716  11.144  6.575   1.00 42.74  ? 41  GLY C C    1 
ATOM   525  O  O    . GLY A 1 36  ? 18.201  10.123  7.080   1.00 38.93  ? 41  GLY C O    1 
ATOM   526  H  H    . GLY A 1 36  ? 17.196  14.181  6.661   1.00 57.54  ? 41  GLY C H    1 
ATOM   527  H  HA2  . GLY A 1 36  ? 17.981  12.221  8.310   1.00 45.22  ? 41  GLY C HA2  1 
ATOM   528  H  HA3  . GLY A 1 36  ? 16.512  12.372  7.708   1.00 45.22  ? 41  GLY C HA3  1 
ATOM   529  N  N    . MET A 1 37  ? 17.410  11.280  5.289   1.00 40.40  ? 42  MET C N    1 
ATOM   530  C  CA   . MET A 1 37  ? 17.633  10.198  4.304   1.00 45.21  ? 42  MET C CA   1 
ATOM   531  C  C    . MET A 1 37  ? 19.133  9.902   4.219   1.00 43.81  ? 42  MET C C    1 
ATOM   532  O  O    . MET A 1 37  ? 19.498  8.720   4.244   1.00 42.79  ? 42  MET C O    1 
ATOM   533  C  CB   . MET A 1 37  ? 17.097  10.612  2.934   1.00 39.44  ? 42  MET C CB   1 
ATOM   534  C  CG   . MET A 1 37  ? 17.084  9.491   1.921   1.00 44.89  ? 42  MET C CG   1 
ATOM   535  S  SD   . MET A 1 37  ? 16.386  9.976   0.332   1.00 47.84  ? 42  MET C SD   1 
ATOM   536  C  CE   . MET A 1 37  ? 14.752  10.511  0.853   1.00 54.26  ? 42  MET C CE   1 
ATOM   537  H  H    . MET A 1 37  ? 17.070  12.049  4.964   1.00 48.53  ? 42  MET C H    1 
ATOM   538  H  HA   . MET A 1 37  ? 17.161  9.386   4.614   1.00 54.30  ? 42  MET C HA   1 
ATOM   539  H  HB2  . MET A 1 37  ? 16.186  10.954  3.051   1.00 47.37  ? 42  MET C HB2  1 
ATOM   540  H  HB3  . MET A 1 37  ? 17.649  11.346  2.591   1.00 47.37  ? 42  MET C HB3  1 
ATOM   541  H  HG2  . MET A 1 37  ? 17.997  9.177   1.777   1.00 53.91  ? 42  MET C HG2  1 
ATOM   542  H  HG3  . MET A 1 37  ? 16.563  8.746   2.278   1.00 53.91  ? 42  MET C HG3  1 
ATOM   543  H  HE1  . MET A 1 37  ? 14.127  10.413  0.112   1.00 65.16  ? 42  MET C HE1  1 
ATOM   544  H  HE2  . MET A 1 37  ? 14.458  9.964   1.605   1.00 65.16  ? 42  MET C HE2  1 
ATOM   545  H  HE3  . MET A 1 37  ? 14.791  11.446  1.129   1.00 65.16  ? 42  MET C HE3  1 
ATOM   546  N  N    . GLN A 1 38  ? 19.961  10.939  4.155   1.00 45.69  ? 43  GLN C N    1 
ATOM   547  C  CA   . GLN A 1 38  ? 21.431  10.786  4.039   1.00 48.29  ? 43  GLN C CA   1 
ATOM   548  C  C    . GLN A 1 38  ? 21.980  10.119  5.300   1.00 51.47  ? 43  GLN C C    1 
ATOM   549  O  O    . GLN A 1 38  ? 22.720  9.140   5.156   1.00 50.79  ? 43  GLN C O    1 
ATOM   550  C  CB   . GLN A 1 38  ? 22.077  12.152  3.835   1.00 49.35  ? 43  GLN C CB   1 
ATOM   551  C  CG   . GLN A 1 38  ? 23.561  12.106  3.495   1.00 58.46  ? 43  GLN C CG   1 
ATOM   552  C  CD   . GLN A 1 38  ? 23.815  11.790  2.040   1.00 69.65  ? 43  GLN C CD   1 
ATOM   553  O  OE1  . GLN A 1 38  ? 23.862  12.681  1.186   1.00 75.76  ? 43  GLN C OE1  1 
ATOM   554  N  NE2  . GLN A 1 38  ? 23.973  10.510  1.744   1.00 71.67  ? 43  GLN C NE2  1 
ATOM   555  H  H    . GLN A 1 38  ? 19.656  11.786  4.196   1.00 54.87  ? 43  GLN C H    1 
ATOM   556  H  HA   . GLN A 1 38  ? 21.626  10.210  3.259   1.00 57.99  ? 43  GLN C HA   1 
ATOM   557  H  HB2  . GLN A 1 38  ? 21.604  12.614  3.114   1.00 59.26  ? 43  GLN C HB2  1 
ATOM   558  H  HB3  . GLN A 1 38  ? 21.956  12.678  4.652   1.00 59.26  ? 43  GLN C HB3  1 
ATOM   559  H  HG2  . GLN A 1 38  ? 23.967  12.972  3.706   1.00 70.19  ? 43  GLN C HG2  1 
ATOM   560  H  HG3  . GLN A 1 38  ? 24.002  11.427  4.047   1.00 70.19  ? 43  GLN C HG3  1 
ATOM   561  H  HE21 . GLN A 1 38  ? 23.776  9.893   2.350   1.00 86.05  ? 43  GLN C HE21 1 
ATOM   562  H  HE22 . GLN A 1 38  ? 24.272  10.273  0.944   1.00 86.05  ? 43  GLN C HE22 1 
ATOM   563  N  N    . ASP A 1 39  ? 21.602  10.605  6.477   1.00 47.83  ? 44  ASP C N    1 
ATOM   564  C  CA   . ASP A 1 39  ? 22.166  10.098  7.755   1.00 47.57  ? 44  ASP C CA   1 
ATOM   565  C  C    . ASP A 1 39  ? 21.765  8.636   7.947   1.00 46.23  ? 44  ASP C C    1 
ATOM   566  O  O    . ASP A 1 39  ? 22.606  7.861   8.426   1.00 48.17  ? 44  ASP C O    1 
ATOM   567  C  CB   . ASP A 1 39  ? 21.784  11.016  8.899   1.00 47.85  ? 44  ASP C CB   1 
ATOM   568  C  CG   . ASP A 1 39  ? 22.336  12.430  8.813   1.00 56.69  ? 44  ASP C CG   1 
ATOM   569  O  OD1  . ASP A 1 39  ? 23.424  12.610  8.235   1.00 64.88  ? 44  ASP C OD1  1 
ATOM   570  O  OD2  . ASP A 1 39  ? 21.668  13.340  9.316   1.00 54.05  ? 44  ASP C OD2  1 
ATOM   571  H  H    . ASP A 1 39  ? 20.975  11.249  6.540   1.00 57.44  ? 44  ASP C H    1 
ATOM   572  H  HA   . ASP A 1 39  ? 23.144  10.129  7.684   1.00 57.13  ? 44  ASP C HA   1 
ATOM   573  H  HB2  . ASP A 1 39  ? 20.807  11.076  8.932   1.00 57.46  ? 44  ASP C HB2  1 
ATOM   574  H  HB3  . ASP A 1 39  ? 22.094  10.616  9.738   1.00 57.46  ? 44  ASP C HB3  1 
ATOM   575  N  N    . ALA A 1 40  ? 20.557  8.263   7.546   1.00 43.69  ? 45  ALA C N    1 
ATOM   576  C  CA   . ALA A 1 40  ? 20.069  6.873   7.675   1.00 42.53  ? 45  ALA C CA   1 
ATOM   577  C  C    . ALA A 1 40  ? 20.867  5.954   6.756   1.00 52.67  ? 45  ALA C C    1 
ATOM   578  O  O    . ALA A 1 40  ? 21.218  4.854   7.193   1.00 56.53  ? 45  ALA C O    1 
ATOM   579  C  CB   . ALA A 1 40  ? 18.603  6.815   7.354   1.00 45.34  ? 45  ALA C CB   1 
ATOM   580  H  H    . ALA A 1 40  ? 19.967  8.833   7.171   1.00 52.47  ? 45  ALA C H    1 
ATOM   581  H  HA   . ALA A 1 40  ? 20.210  6.577   8.615   1.00 51.08  ? 45  ALA C HA   1 
ATOM   582  H  HB1  . ALA A 1 40  ? 18.304  5.891   7.365   1.00 54.45  ? 45  ALA C HB1  1 
ATOM   583  H  HB2  . ALA A 1 40  ? 18.104  7.324   8.015   1.00 54.45  ? 45  ALA C HB2  1 
ATOM   584  H  HB3  . ALA A 1 40  ? 18.448  7.192   6.472   1.00 54.45  ? 45  ALA C HB3  1 
ATOM   585  N  N    . MET A 1 41  ? 21.178  6.403   5.547   1.00 50.51  ? 46  MET C N    1 
ATOM   586  C  CA   . MET A 1 41  ? 21.875  5.564   4.542   1.00 52.08  ? 46  MET C CA   1 
ATOM   587  C  C    . MET A 1 41  ? 23.374  5.495   4.864   1.00 55.82  ? 46  MET C C    1 
ATOM   588  O  O    . MET A 1 41  ? 23.959  4.430   4.645   1.00 49.14  ? 46  MET C O    1 
ATOM   589  C  CB   . MET A 1 41  ? 21.638  6.152   3.149   1.00 40.04  ? 46  MET C CB   1 
ATOM   590  C  CG   . MET A 1 41  ? 20.173  6.270   2.790   1.00 53.70  ? 46  MET C CG   1 
ATOM   591  S  SD   . MET A 1 41  ? 19.868  6.495   1.028   1.00 52.01  ? 46  MET C SD   1 
ATOM   592  C  CE   . MET A 1 41  ? 20.175  4.819   0.460   1.00 58.09  ? 46  MET C CE   1 
ATOM   593  H  H    . MET A 1 41  ? 20.993  7.251   5.300   1.00 60.66  ? 46  MET C H    1 
ATOM   594  H  HA   . MET A 1 41  ? 21.499  4.651   4.580   1.00 62.54  ? 46  MET C HA   1 
ATOM   595  H  HB2  . MET A 1 41  ? 22.050  7.041   3.111   1.00 48.09  ? 46  MET C HB2  1 
ATOM   596  H  HB3  . MET A 1 41  ? 22.086  5.584   2.489   1.00 48.09  ? 46  MET C HB3  1 
ATOM   597  H  HG2  . MET A 1 41  ? 19.709  5.463   3.086   1.00 64.48  ? 46  MET C HG2  1 
ATOM   598  H  HG3  . MET A 1 41  ? 19.787  7.029   3.271   1.00 64.48  ? 46  MET C HG3  1 
ATOM   599  H  HE1  . MET A 1 41  ? 20.023  4.769   -0.501  1.00 69.75  ? 46  MET C HE1  1 
ATOM   600  H  HE2  . MET A 1 41  ? 21.097  4.574   0.659   1.00 69.75  ? 46  MET C HE2  1 
ATOM   601  H  HE3  . MET A 1 41  ? 19.571  4.207   0.920   1.00 69.75  ? 46  MET C HE3  1 
ATOM   602  N  N    . SER A 1 42  ? 23.956  6.583   5.367   1.00 57.45  ? 47  SER C N    1 
ATOM   603  C  CA   . SER A 1 42  ? 25.397  6.664   5.721   1.00 54.09  ? 47  SER C CA   1 
ATOM   604  C  C    . SER A 1 42  ? 25.702  5.811   6.958   1.00 51.44  ? 47  SER C C    1 
ATOM   605  O  O    . SER A 1 42  ? 26.870  5.434   7.129   1.00 53.97  ? 47  SER C O    1 
ATOM   606  C  CB   . SER A 1 42  ? 25.787  8.093   5.948   1.00 43.90  ? 47  SER C CB   1 
ATOM   607  O  OG   . SER A 1 42  ? 25.350  8.547   7.219   1.00 54.72  ? 47  SER C OG   1 
ATOM   608  H  H    . SER A 1 42  ? 23.483  7.334   5.523   1.00 68.98  ? 47  SER C H    1 
ATOM   609  H  HA   . SER A 1 42  ? 25.923  6.311   4.961   1.00 64.95  ? 47  SER C HA   1 
ATOM   610  H  HB2  . SER A 1 42  ? 26.758  8.173   5.892   1.00 52.72  ? 47  SER C HB2  1 
ATOM   611  H  HB3  . SER A 1 42  ? 25.392  8.648   5.251   1.00 52.72  ? 47  SER C HB3  1 
ATOM   612  H  HG   . SER A 1 42  ? 25.073  9.343   7.140   1.00 65.70  ? 47  SER C HG   1 
ATOM   613  N  N    . GLY A 1 43  ? 24.700  5.529   7.785   1.00 53.53  ? 48  GLY C N    1 
ATOM   614  C  CA   . GLY A 1 43  ? 24.882  4.757   9.023   1.00 48.60  ? 48  GLY C CA   1 
ATOM   615  C  C    . GLY A 1 43  ? 25.290  5.661   10.158  1.00 47.62  ? 48  GLY C C    1 
ATOM   616  O  O    . GLY A 1 43  ? 25.823  5.149   11.152  1.00 54.62  ? 48  GLY C O    1 
ATOM   617  H  H    . GLY A 1 43  ? 23.858  5.820   7.623   1.00 64.28  ? 48  GLY C H    1 
ATOM   618  H  HA2  . GLY A 1 43  ? 24.036  4.306   9.249   1.00 58.36  ? 48  GLY C HA2  1 
ATOM   619  H  HA3  . GLY A 1 43  ? 25.569  4.066   8.884   1.00 58.36  ? 48  GLY C HA3  1 
ATOM   620  N  N    . ALA A 1 44  ? 25.036  6.954   10.034  1.00 51.54  ? 49  ALA C N    1 
ATOM   621  C  CA   . ALA A 1 44  ? 25.402  7.946   11.061  1.00 42.88  ? 49  ALA C CA   1 
ATOM   622  C  C    . ALA A 1 44  ? 24.465  7.872   12.261  1.00 51.85  ? 49  ALA C C    1 
ATOM   623  O  O    . ALA A 1 44  ? 23.505  7.083   12.238  1.00 54.41  ? 49  ALA C O    1 
ATOM   624  C  CB   . ALA A 1 44  ? 25.353  9.316   10.449  1.00 48.08  ? 49  ALA C CB   1 
ATOM   625  H  H    . ALA A 1 44  ? 24.625  7.305   9.312   1.00 61.90  ? 49  ALA C H    1 
ATOM   626  H  HA   . ALA A 1 44  ? 26.329  7.755   11.370  1.00 51.50  ? 49  ALA C HA   1 
ATOM   627  H  HB1  . ALA A 1 44  ? 25.958  9.909   10.925  1.00 57.74  ? 49  ALA C HB1  1 
ATOM   628  H  HB2  . ALA A 1 44  ? 25.616  9.268   9.515   1.00 57.74  ? 49  ALA C HB2  1 
ATOM   629  H  HB3  . ALA A 1 44  ? 24.447  9.667   10.509  1.00 57.74  ? 49  ALA C HB3  1 
ATOM   630  N  N    . GLN A 1 45  ? 24.740  8.678   13.282  1.00 58.24  ? 50  GLN C N    1 
ATOM   631  C  CA   . GLN A 1 45  ? 23.869  8.770   14.473  1.00 56.16  ? 50  GLN C CA   1 
ATOM   632  C  C    . GLN A 1 45  ? 22.812  9.834   14.174  1.00 52.28  ? 50  GLN C C    1 
ATOM   633  O  O    . GLN A 1 45  ? 23.194  10.989  13.945  1.00 59.83  ? 50  GLN C O    1 
ATOM   634  C  CB   . GLN A 1 45  ? 24.703  9.121   15.701  1.00 64.84  ? 50  GLN C CB   1 
ATOM   635  C  CG   . GLN A 1 45  ? 25.042  7.919   16.574  1.00 69.03  ? 50  GLN C CG   1 
ATOM   636  C  CD   . GLN A 1 45  ? 23.914  7.528   17.503  1.00 82.43  ? 50  GLN C CD   1 
ATOM   637  O  OE1  . GLN A 1 45  ? 23.497  8.301   18.372  1.00 84.45  ? 50  GLN C OE1  1 
ATOM   638  N  NE2  . GLN A 1 45  ? 23.404  6.319   17.321  1.00 75.29  ? 50  GLN C NE2  1 
ATOM   639  H  H    . GLN A 1 45  ? 25.475  9.201   13.287  1.00 69.93  ? 50  GLN C H    1 
ATOM   640  H  HA   . GLN A 1 45  ? 23.424  7.898   14.619  1.00 67.43  ? 50  GLN C HA   1 
ATOM   641  H  HB2  . GLN A 1 45  ? 25.535  9.545   15.407  1.00 77.85  ? 50  GLN C HB2  1 
ATOM   642  H  HB3  . GLN A 1 45  ? 24.209  9.776   16.237  1.00 77.85  ? 50  GLN C HB3  1 
ATOM   643  H  HG2  . GLN A 1 45  ? 25.257  7.154   15.999  1.00 82.88  ? 50  GLN C HG2  1 
ATOM   644  H  HG3  . GLN A 1 45  ? 25.837  8.123   17.111  1.00 82.88  ? 50  GLN C HG3  1 
ATOM   645  H  HE21 . GLN A 1 45  ? 23.659  5.831   16.626  1.00 90.40  ? 50  GLN C HE21 1 
ATOM   646  H  HE22 . GLN A 1 45  ? 22.807  6.001   17.893  1.00 90.40  ? 50  GLN C HE22 1 
ATOM   647  N  N    . LEU A 1 46  ? 21.543  9.453   14.169  1.00 49.25  ? 51  LEU C N    1 
ATOM   648  C  CA   . LEU A 1 46  ? 20.452  10.389  13.822  1.00 50.44  ? 51  LEU C CA   1 
ATOM   649  C  C    . LEU A 1 46  ? 20.218  11.378  14.969  1.00 45.61  ? 51  LEU C C    1 
ATOM   650  O  O    . LEU A 1 46  ? 20.345  10.977  16.133  1.00 53.37  ? 51  LEU C O    1 
ATOM   651  C  CB   . LEU A 1 46  ? 19.214  9.572   13.468  1.00 42.64  ? 51  LEU C CB   1 
ATOM   652  C  CG   . LEU A 1 46  ? 19.400  8.514   12.377  1.00 45.98  ? 51  LEU C CG   1 
ATOM   653  C  CD1  . LEU A 1 46  ? 18.091  7.819   12.074  1.00 52.16  ? 51  LEU C CD1  1 
ATOM   654  C  CD2  . LEU A 1 46  ? 19.989  9.119   11.118  1.00 52.22  ? 51  LEU C CD2  1 
ATOM   655  H  H    . LEU A 1 46  ? 21.301  8.609   14.373  1.00 59.15  ? 51  LEU C H    1 
ATOM   656  H  HA   . LEU A 1 46  ? 20.731  10.904  13.028  1.00 60.57  ? 51  LEU C HA   1 
ATOM   657  H  HB2  . LEU A 1 46  ? 18.901  9.124   14.287  1.00 51.21  ? 51  LEU C HB2  1 
ATOM   658  H  HB3  . LEU A 1 46  ? 18.509  10.196  13.180  1.00 51.21  ? 51  LEU C HB3  1 
ATOM   659  H  HG   . LEU A 1 46  ? 20.035  7.829   12.713  1.00 55.22  ? 51  LEU C HG   1 
ATOM   660  H  HD11 . LEU A 1 46  ? 18.214  7.202   11.333  1.00 62.64  ? 51  LEU C HD11 1 
ATOM   661  H  HD12 . LEU A 1 46  ? 17.794  7.327   12.859  1.00 62.64  ? 51  LEU C HD12 1 
ATOM   662  H  HD13 . LEU A 1 46  ? 17.420  8.480   11.835  1.00 62.64  ? 51  LEU C HD13 1 
ATOM   663  H  HD21 . LEU A 1 46  ? 19.760  8.564   10.352  1.00 62.71  ? 51  LEU C HD21 1 
ATOM   664  H  HD22 . LEU A 1 46  ? 19.631  10.013  10.988  1.00 62.71  ? 51  LEU C HD22 1 
ATOM   665  H  HD23 . LEU A 1 46  ? 20.956  9.168   11.203  1.00 62.71  ? 51  LEU C HD23 1 
ATOM   666  N  N    . ALA A 1 47  ? 19.879  12.619  14.645  1.00 47.81  ? 52  ALA C N    1 
ATOM   667  C  CA   . ALA A 1 47  ? 19.638  13.696  15.631  1.00 45.82  ? 52  ALA C CA   1 
ATOM   668  C  C    . ALA A 1 47  ? 18.407  13.417  16.491  1.00 47.16  ? 52  ALA C C    1 
ATOM   669  O  O    . ALA A 1 47  ? 18.273  14.080  17.530  1.00 48.84  ? 52  ALA C O    1 
ATOM   670  C  CB   . ALA A 1 47  ? 19.489  14.976  14.874  1.00 54.56  ? 52  ALA C CB   1 
ATOM   671  H  H    . ALA A 1 47  ? 19.768  12.882  13.790  1.00 57.41  ? 52  ALA C H    1 
ATOM   672  H  HA   . ALA A 1 47  ? 20.431  13.758  16.228  1.00 55.03  ? 52  ALA C HA   1 
ATOM   673  H  HB1  . ALA A 1 47  ? 19.570  15.728  15.485  1.00 65.51  ? 52  ALA C HB1  1 
ATOM   674  H  HB2  . ALA A 1 47  ? 20.182  15.036  14.196  1.00 65.51  ? 52  ALA C HB2  1 
ATOM   675  H  HB3  . ALA A 1 47  ? 18.617  15.001  14.446  1.00 65.51  ? 52  ALA C HB3  1 
ATOM   676  N  N    . LEU A 1 48  ? 17.534  12.509  16.072  1.00 45.20  ? 53  LEU C N    1 
ATOM   677  C  CA   . LEU A 1 48  ? 16.362  12.101  16.879  1.00 47.82  ? 53  LEU C CA   1 
ATOM   678  C  C    . LEU A 1 48  ? 16.488  10.614  17.210  1.00 45.42  ? 53  LEU C C    1 
ATOM   679  O  O    . LEU A 1 48  ? 17.012  9.876   16.368  1.00 47.89  ? 53  LEU C O    1 
ATOM   680  C  CB   . LEU A 1 48  ? 15.067  12.384  16.125  1.00 43.99  ? 53  LEU C CB   1 
ATOM   681  C  CG   . LEU A 1 48  ? 14.669  13.849  15.978  1.00 39.46  ? 53  LEU C CG   1 
ATOM   682  C  CD1  . LEU A 1 48  ? 13.635  13.948  14.888  1.00 48.05  ? 53  LEU C CD1  1 
ATOM   683  C  CD2  . LEU A 1 48  ? 14.140  14.373  17.287  1.00 51.15  ? 53  LEU C CD2  1 
ATOM   684  H  H    . LEU A 1 48  ? 17.608  12.118  15.263  1.00 54.29  ? 53  LEU C H    1 
ATOM   685  H  HA   . LEU A 1 48  ? 16.357  12.606  17.726  1.00 57.43  ? 53  LEU C HA   1 
ATOM   686  H  HB2  . LEU A 1 48  ? 15.147  11.992  15.226  1.00 52.83  ? 53  LEU C HB2  1 
ATOM   687  H  HB3  . LEU A 1 48  ? 14.337  11.911  16.588  1.00 52.83  ? 53  LEU C HB3  1 
ATOM   688  H  HG   . LEU A 1 48  ? 15.469  14.373  15.716  1.00 47.40  ? 53  LEU C HG   1 
ATOM   689  H  HD11 . LEU A 1 48  ? 13.388  14.879  14.759  1.00 57.71  ? 53  LEU C HD11 1 
ATOM   690  H  HD12 . LEU A 1 48  ? 14.000  13.591  14.061  1.00 57.71  ? 53  LEU C HD12 1 
ATOM   691  H  HD13 . LEU A 1 48  ? 12.849  13.436  15.142  1.00 57.71  ? 53  LEU C HD13 1 
ATOM   692  H  HD21 . LEU A 1 48  ? 13.696  15.224  17.142  1.00 61.43  ? 53  LEU C HD21 1 
ATOM   693  H  HD22 . LEU A 1 48  ? 13.506  13.736  17.657  1.00 61.43  ? 53  LEU C HD22 1 
ATOM   694  H  HD23 . LEU A 1 48  ? 14.877  14.493  17.910  1.00 61.43  ? 53  LEU C HD23 1 
ATOM   695  N  N    . THR A 1 49  ? 16.004  10.192  18.373  1.00 44.11  ? 54  THR C N    1 
ATOM   696  C  CA   . THR A 1 49  ? 16.007  8.777   18.783  1.00 46.59  ? 54  THR C CA   1 
ATOM   697  C  C    . THR A 1 49  ? 14.941  8.060   17.994  1.00 53.25  ? 54  THR C C    1 
ATOM   698  O  O    . THR A 1 49  ? 14.119  8.738   17.362  1.00 53.11  ? 54  THR C O    1 
ATOM   699  C  CB   . THR A 1 49  ? 15.767  8.667   20.288  1.00 52.19  ? 54  THR C CB   1 
ATOM   700  O  OG1  . THR A 1 49  ? 14.459  9.169   20.525  1.00 49.00  ? 54  THR C OG1  1 
ATOM   701  C  CG2  . THR A 1 49  ? 16.784  9.455   21.093  1.00 51.47  ? 54  THR C CG2  1 
ATOM   702  H  H    . THR A 1 49  ? 15.601  10.731  18.974  1.00 52.98  ? 54  THR C H    1 
ATOM   703  H  HA   . THR A 1 49  ? 16.882  8.388   18.570  1.00 55.96  ? 54  THR C HA   1 
ATOM   704  H  HB   . THR A 1 49  ? 15.806  7.717   20.555  1.00 62.67  ? 54  THR C HB   1 
ATOM   705  H  HG1  . THR A 1 49  ? 14.472  9.694   21.208  1.00 58.85  ? 54  THR C HG1  1 
ATOM   706  H  HG21 . THR A 1 49  ? 16.861  9.073   21.982  1.00 61.81  ? 54  THR C HG21 1 
ATOM   707  H  HG22 . THR A 1 49  ? 17.647  9.418   20.648  1.00 61.81  ? 54  THR C HG22 1 
ATOM   708  H  HG23 . THR A 1 49  ? 16.497  10.381  21.162  1.00 61.81  ? 54  THR C HG23 1 
ATOM   709  N  N    . GLU A 1 50  ? 14.934  6.734   18.038  1.00 48.09  ? 55  GLU C N    1 
ATOM   710  C  CA   . GLU A 1 50  ? 13.932  5.935   17.297  1.00 50.54  ? 55  GLU C CA   1 
ATOM   711  C  C    . GLU A 1 50  ? 12.540  6.165   17.897  1.00 51.87  ? 55  GLU C C    1 
ATOM   712  O  O    . GLU A 1 50  ? 11.578  6.161   17.124  1.00 48.28  ? 55  GLU C O    1 
ATOM   713  C  CB   . GLU A 1 50  ? 14.303  4.458   17.320  1.00 60.28  ? 55  GLU C CB   1 
ATOM   714  C  CG   . GLU A 1 50  ? 15.201  4.055   16.156  1.00 80.97  ? 55  GLU C CG   1 
ATOM   715  C  CD   . GLU A 1 50  ? 14.543  4.031   14.787  1.00 88.36  ? 55  GLU C CD   1 
ATOM   716  O  OE1  . GLU A 1 50  ? 13.311  4.216   14.694  1.00 88.42  ? 55  GLU C OE1  1 
ATOM   717  O  OE2  . GLU A 1 50  ? 15.280  3.828   13.801  1.00 90.68  ? 55  GLU C OE2  1 
ATOM   718  H  H    . GLU A 1 50  ? 15.538  6.274   18.525  1.00 57.75  ? 55  GLU C H    1 
ATOM   719  H  HA   . GLU A 1 50  ? 13.923  6.250   16.360  1.00 60.70  ? 55  GLU C HA   1 
ATOM   720  H  HB2  . GLU A 1 50  ? 14.767  4.265   18.161  1.00 72.38  ? 55  GLU C HB2  1 
ATOM   721  H  HB3  . GLU A 1 50  ? 13.482  3.925   17.305  1.00 72.38  ? 55  GLU C HB3  1 
ATOM   722  H  HG2  . GLU A 1 50  ? 15.958  4.676   16.118  1.00 97.21  ? 55  GLU C HG2  1 
ATOM   723  H  HG3  . GLU A 1 50  ? 15.566  3.163   16.335  1.00 97.21  ? 55  GLU C HG3  1 
ATOM   724  N  N    . GLN A 1 51  ? 12.450  6.364   19.209  1.00 54.04  ? 56  GLN C N    1 
ATOM   725  C  CA   . GLN A 1 51  ? 11.159  6.618   19.894  1.00 50.00  ? 56  GLN C CA   1 
ATOM   726  C  C    . GLN A 1 51  ? 10.675  8.030   19.557  1.00 55.32  ? 56  GLN C C    1 
ATOM   727  O  O    . GLN A 1 51  ? 9.480   8.175   19.289  1.00 57.95  ? 56  GLN C O    1 
ATOM   728  C  CB   . GLN A 1 51  ? 11.314  6.455   21.402  1.00 55.68  ? 56  GLN C CB   1 
ATOM   729  C  CG   . GLN A 1 51  ? 10.004  6.480   22.181  1.00 66.08  ? 56  GLN C CG   1 
ATOM   730  C  CD   . GLN A 1 51  ? 9.062   5.359   21.806  1.00 78.24  ? 56  GLN C CD   1 
ATOM   731  O  OE1  . GLN A 1 51  ? 9.472   4.218   21.568  1.00 77.63  ? 56  GLN C OE1  1 
ATOM   732  N  NE2  . GLN A 1 51  ? 7.780   5.681   21.750  1.00 81.07  ? 56  GLN C NE2  1 
ATOM   733  H  H    . GLN A 1 51  ? 13.180  6.350   19.738  1.00 64.89  ? 56  GLN C H    1 
ATOM   734  H  HA   . GLN A 1 51  ? 10.494  5.966   19.557  1.00 60.04  ? 56  GLN C HA   1 
ATOM   735  H  HB2  . GLN A 1 51  ? 11.770  5.606   21.576  1.00 66.86  ? 56  GLN C HB2  1 
ATOM   736  H  HB3  . GLN A 1 51  ? 11.891  7.173   21.732  1.00 66.86  ? 56  GLN C HB3  1 
ATOM   737  H  HG2  . GLN A 1 51  ? 10.199  6.418   23.139  1.00 79.35  ? 56  GLN C HG2  1 
ATOM   738  H  HG3  . GLN A 1 51  ? 9.551   7.335   22.025  1.00 79.35  ? 56  GLN C HG3  1 
ATOM   739  H  HE21 . GLN A 1 51  ? 7.530   6.415   21.321  1.00 97.33  ? 56  GLN C HE21 1 
ATOM   740  H  HE22 . GLN A 1 51  ? 7.174   5.159   22.133  1.00 97.33  ? 56  GLN C HE22 1 
ATOM   741  N  N    . GLN A 1 52  ? 11.562  9.022   19.575  1.00 45.69  ? 57  GLN C N    1 
ATOM   742  C  CA   . GLN A 1 52  ? 11.202  10.408  19.203  1.00 51.24  ? 57  GLN C CA   1 
ATOM   743  C  C    . GLN A 1 52  ? 10.579  10.417  17.800  1.00 55.99  ? 57  GLN C C    1 
ATOM   744  O  O    . GLN A 1 52  ? 9.528   11.049  17.629  1.00 48.45  ? 57  GLN C O    1 
ATOM   745  C  CB   . GLN A 1 52  ? 12.426  11.313  19.195  1.00 47.94  ? 57  GLN C CB   1 
ATOM   746  C  CG   . GLN A 1 52  ? 12.760  11.939  20.540  1.00 52.14  ? 57  GLN C CG   1 
ATOM   747  C  CD   . GLN A 1 52  ? 13.952  12.863  20.455  1.00 57.28  ? 57  GLN C CD   1 
ATOM   748  O  OE1  . GLN A 1 52  ? 15.086  12.436  20.222  1.00 56.65  ? 57  GLN C OE1  1 
ATOM   749  N  NE2  . GLN A 1 52  ? 13.697  14.152  20.610  1.00 65.84  ? 57  GLN C NE2  1 
ATOM   750  H  H    . GLN A 1 52  ? 12.423  8.884   19.808  1.00 54.88  ? 57  GLN C H    1 
ATOM   751  H  HA   . GLN A 1 52  ? 10.541  10.750  19.855  1.00 61.54  ? 57  GLN C HA   1 
ATOM   752  H  HB2  . GLN A 1 52  ? 13.196  10.793  18.888  1.00 57.57  ? 57  GLN C HB2  1 
ATOM   753  H  HB3  . GLN A 1 52  ? 12.278  12.029  18.544  1.00 57.57  ? 57  GLN C HB3  1 
ATOM   754  H  HG2  . GLN A 1 52  ? 11.986  12.448  20.860  1.00 62.61  ? 57  GLN C HG2  1 
ATOM   755  H  HG3  . GLN A 1 52  ? 12.945  11.233  21.192  1.00 62.61  ? 57  GLN C HG3  1 
ATOM   756  H  HE21 . GLN A 1 52  ? 13.003  14.410  21.097  1.00 79.05  ? 57  GLN C HE21 1 
ATOM   757  H  HE22 . GLN A 1 52  ? 14.217  14.754  20.218  1.00 79.05  ? 57  GLN C HE22 1 
ATOM   758  N  N    . MET A 1 53  ? 11.215  9.737   16.849  1.00 45.48  ? 58  MET C N    1 
ATOM   759  C  CA   . MET A 1 53  ? 10.748  9.718   15.445  1.00 47.52  ? 58  MET C CA   1 
ATOM   760  C  C    . MET A 1 53  ? 9.457   8.903   15.349  1.00 49.94  ? 58  MET C C    1 
ATOM   761  O  O    . MET A 1 53  ? 8.631   9.251   14.521  1.00 47.68  ? 58  MET C O    1 
ATOM   762  C  CB   . MET A 1 53  ? 11.817  9.107   14.541  1.00 42.44  ? 58  MET C CB   1 
ATOM   763  C  CG   . MET A 1 53  ? 13.022  9.992   14.321  1.00 44.46  ? 58  MET C CG   1 
ATOM   764  S  SD   . MET A 1 53  ? 14.172  9.292   13.122  1.00 49.04  ? 58  MET C SD   1 
ATOM   765  C  CE   . MET A 1 53  ? 14.885  7.988   14.132  1.00 53.59  ? 58  MET C CE   1 
ATOM   766  H  H    . MET A 1 53  ? 11.954  9.247   17.016  1.00 54.62  ? 58  MET C H    1 
ATOM   767  H  HA   . MET A 1 53  ? 10.564  10.649  15.161  1.00 57.07  ? 58  MET C HA   1 
ATOM   768  H  HB2  . MET A 1 53  ? 12.114  8.263   14.942  1.00 50.98  ? 58  MET C HB2  1 
ATOM   769  H  HB3  . MET A 1 53  ? 11.411  8.900   13.674  1.00 50.98  ? 58  MET C HB3  1 
ATOM   770  H  HG2  . MET A 1 53  ? 12.727  10.869  14.005  1.00 53.39  ? 58  MET C HG2  1 
ATOM   771  H  HG3  . MET A 1 53  ? 13.489  10.119  15.169  1.00 53.39  ? 58  MET C HG3  1 
ATOM   772  H  HE1  . MET A 1 53  ? 15.563  7.511   13.619  1.00 64.35  ? 58  MET C HE1  1 
ATOM   773  H  HE2  . MET A 1 53  ? 15.293  8.380   14.926  1.00 64.35  ? 58  MET C HE2  1 
ATOM   774  H  HE3  . MET A 1 53  ? 14.184  7.367   14.405  1.00 64.35  ? 58  MET C HE3  1 
ATOM   775  N  N    . LYS A 1 54  ? 9.314   7.859   16.161  1.00 45.53  ? 59  LYS C N    1 
ATOM   776  C  CA   . LYS A 1 54  ? 8.095   7.016   16.160  1.00 53.85  ? 59  LYS C CA   1 
ATOM   777  C  C    . LYS A 1 54  ? 6.942   7.827   16.751  1.00 51.39  ? 59  LYS C C    1 
ATOM   778  O  O    . LYS A 1 54  ? 5.815   7.598   16.340  1.00 56.44  ? 59  LYS C O    1 
ATOM   779  C  CB   . LYS A 1 54  ? 8.328   5.724   16.943  1.00 58.00  ? 59  LYS C CB   1 
ATOM   780  C  CG   . LYS A 1 54  ? 7.206   4.710   16.897  1.00 67.77  ? 59  LYS C CG   1 
ATOM   781  C  CD   . LYS A 1 54  ? 7.400   3.571   17.885  1.00 75.70  ? 59  LYS C CD   1 
ATOM   782  C  CE   . LYS A 1 54  ? 7.004   3.980   19.260  1.00 73.78  ? 59  LYS C CE   1 
ATOM   783  N  NZ   . LYS A 1 54  ? 5.583   3.749   19.512  1.00 85.67  ? 59  LYS C NZ   1 
ATOM   784  H  H    . LYS A 1 54  ? 9.957   7.627   16.749  1.00 54.68  ? 59  LYS C H    1 
ATOM   785  H  HA   . LYS A 1 54  ? 7.874   6.785   15.223  1.00 64.67  ? 59  LYS C HA   1 
ATOM   786  H  HB2  . LYS A 1 54  ? 9.139   5.297   16.599  1.00 69.65  ? 59  LYS C HB2  1 
ATOM   787  H  HB3  . LYS A 1 54  ? 8.495   5.960   17.881  1.00 69.65  ? 59  LYS C HB3  1 
ATOM   788  H  HG2  . LYS A 1 54  ? 6.361   5.162   17.099  1.00 81.37  ? 59  LYS C HG2  1 
ATOM   789  H  HG3  . LYS A 1 54  ? 7.147   4.345   15.988  1.00 81.37  ? 59  LYS C HG3  1 
ATOM   790  H  HD2  . LYS A 1 54  ? 6.855   2.804   17.607  1.00 90.89  ? 59  LYS C HD2  1 
ATOM   791  H  HD3  . LYS A 1 54  ? 8.344   3.303   17.886  1.00 90.89  ? 59  LYS C HD3  1 
ATOM   792  H  HE2  . LYS A 1 54  ? 7.526   3.484   19.912  1.00 88.58  ? 59  LYS C HE2  1 
ATOM   793  H  HE3  . LYS A 1 54  ? 7.189   4.929   19.369  1.00 88.58  ? 59  LYS C HE3  1 
ATOM   794  H  HZ1  . LYS A 1 54  ? 5.425   2.860   19.567  1.00 102.84 ? 59  LYS C HZ1  1 
ATOM   795  H  HZ2  . LYS A 1 54  ? 5.342   4.148   20.288  1.00 102.84 ? 59  LYS C HZ2  1 
ATOM   796  H  HZ3  . LYS A 1 54  ? 5.097   4.097   18.833  1.00 102.84 ? 59  LYS C HZ3  1 
ATOM   797  N  N    . ASP A 1 55  ? 7.233   8.739   17.667  1.00 53.46  ? 60  ASP C N    1 
ATOM   798  C  CA   . ASP A 1 55  ? 6.201   9.596   18.294  1.00 52.38  ? 60  ASP C CA   1 
ATOM   799  C  C    . ASP A 1 55  ? 5.724   10.635  17.277  1.00 54.16  ? 60  ASP C C    1 
ATOM   800  O  O    . ASP A 1 55  ? 4.518   10.851  17.217  1.00 48.22  ? 60  ASP C O    1 
ATOM   801  C  CB   . ASP A 1 55  ? 6.737   10.250  19.553  1.00 53.42  ? 60  ASP C CB   1 
ATOM   802  C  CG   . ASP A 1 55  ? 6.752   9.391   20.809  1.00 66.05  ? 60  ASP C CG   1 
ATOM   803  O  OD1  . ASP A 1 55  ? 6.032   8.375   20.843  1.00 61.23  ? 60  ASP C OD1  1 
ATOM   804  O  OD2  . ASP A 1 55  ? 7.480   9.756   21.751  1.00 62.86  ? 60  ASP C OD2  1 
ATOM   805  H  H    . ASP A 1 55  ? 8.080   8.875   17.941  1.00 64.20  ? 60  ASP C H    1 
ATOM   806  H  HA   . ASP A 1 55  ? 5.434   9.032   18.529  1.00 62.90  ? 60  ASP C HA   1 
ATOM   807  H  HB2  . ASP A 1 55  ? 7.656   10.537  19.381  1.00 64.14  ? 60  ASP C HB2  1 
ATOM   808  H  HB3  . ASP A 1 55  ? 6.201   11.049  19.734  1.00 64.14  ? 60  ASP C HB3  1 
ATOM   809  N  N    . VAL A 1 56  ? 6.633   11.265  16.536  1.00 53.53  ? 61  VAL C N    1 
ATOM   810  C  CA   . VAL A 1 56  ? 6.297   12.288  15.503  1.00 48.30  ? 61  VAL C CA   1 
ATOM   811  C  C    . VAL A 1 56  ? 5.418   11.680  14.401  1.00 43.81  ? 61  VAL C C    1 
ATOM   812  O  O    . VAL A 1 56  ? 4.419   12.314  14.039  1.00 47.88  ? 61  VAL C O    1 
ATOM   813  C  CB   . VAL A 1 56  ? 7.612   12.849  14.939  1.00 45.67  ? 61  VAL C CB   1 
ATOM   814  C  CG1  . VAL A 1 56  ? 7.436   13.510  13.580  1.00 42.84  ? 61  VAL C CG1  1 
ATOM   815  C  CG2  . VAL A 1 56  ? 8.277   13.803  15.916  1.00 50.63  ? 61  VAL C CG2  1 
ATOM   816  H  H    . VAL A 1 56  ? 7.513   11.115  16.663  1.00 64.28  ? 61  VAL C H    1 
ATOM   817  H  HA   . VAL A 1 56  ? 5.806   13.013  15.933  1.00 58.01  ? 61  VAL C HA   1 
ATOM   818  H  HB   . VAL A 1 56  ? 8.220   12.084  14.817  1.00 54.85  ? 61  VAL C HB   1 
ATOM   819  H  HG11 . VAL A 1 56  ? 8.195   14.090  13.405  1.00 51.45  ? 61  VAL C HG11 1 
ATOM   820  H  HG12 . VAL A 1 56  ? 7.386   12.828  12.889  1.00 51.45  ? 61  VAL C HG12 1 
ATOM   821  H  HG13 . VAL A 1 56  ? 6.620   14.038  13.577  1.00 51.45  ? 61  VAL C HG13 1 
ATOM   822  H  HG21 . VAL A 1 56  ? 9.213   13.908  15.680  1.00 60.80  ? 61  VAL C HG21 1 
ATOM   823  H  HG22 . VAL A 1 56  ? 7.834   14.667  15.877  1.00 60.80  ? 61  VAL C HG22 1 
ATOM   824  H  HG23 . VAL A 1 56  ? 8.209   13.445  16.817  1.00 60.80  ? 61  VAL C HG23 1 
ATOM   825  N  N    . LEU A 1 57  ? 5.753   10.492  13.924  1.00 42.00  ? 62  LEU C N    1 
ATOM   826  C  CA   . LEU A 1 57  ? 5.029   9.876   12.789  1.00 44.25  ? 62  LEU C CA   1 
ATOM   827  C  C    . LEU A 1 57  ? 3.647   9.354   13.214  1.00 55.87  ? 62  LEU C C    1 
ATOM   828  O  O    . LEU A 1 57  ? 2.715   9.493   12.417  1.00 55.46  ? 62  LEU C O    1 
ATOM   829  C  CB   . LEU A 1 57  ? 5.923   8.783   12.219  1.00 42.18  ? 62  LEU C CB   1 
ATOM   830  C  CG   . LEU A 1 57  ? 7.194   9.262   11.516  1.00 50.02  ? 62  LEU C CG   1 
ATOM   831  C  CD1  . LEU A 1 57  ? 8.074   8.085   11.158  1.00 44.66  ? 62  LEU C CD1  1 
ATOM   832  C  CD2  . LEU A 1 57  ? 6.858   10.080  10.290  1.00 41.56  ? 62  LEU C CD2  1 
ATOM   833  H  H    . LEU A 1 57  ? 6.432   10.018  14.279  1.00 50.44  ? 62  LEU C H    1 
ATOM   834  H  HA   . LEU A 1 57  ? 4.893   10.574  12.100  1.00 53.15  ? 62  LEU C HA   1 
ATOM   835  H  HB2  . LEU A 1 57  ? 6.183   8.184   12.957  1.00 50.66  ? 62  LEU C HB2  1 
ATOM   836  H  HB3  . LEU A 1 57  ? 5.393   8.256   11.577  1.00 50.66  ? 62  LEU C HB3  1 
ATOM   837  H  HG   . LEU A 1 57  ? 7.695   9.844   12.142  1.00 60.06  ? 62  LEU C HG   1 
ATOM   838  H  HD11 . LEU A 1 57  ? 8.879   8.403   10.716  1.00 53.64  ? 62  LEU C HD11 1 
ATOM   839  H  HD12 . LEU A 1 57  ? 8.317   7.604   11.967  1.00 53.64  ? 62  LEU C HD12 1 
ATOM   840  H  HD13 . LEU A 1 57  ? 7.591   7.489   10.561  1.00 53.64  ? 62  LEU C HD13 1 
ATOM   841  H  HD21 . LEU A 1 57  ? 7.559   9.975   9.626   1.00 49.91  ? 62  LEU C HD21 1 
ATOM   842  H  HD22 . LEU A 1 57  ? 6.012   9.776   9.920   1.00 49.91  ? 62  LEU C HD22 1 
ATOM   843  H  HD23 . LEU A 1 57  ? 6.783   11.018  10.537  1.00 49.91  ? 62  LEU C HD23 1 
ATOM   844  N  N    . ASN A 1 58  ? 3.521   8.786   14.411  1.00 53.41  ? 63  ASN C N    1 
ATOM   845  C  CA   . ASN A 1 58  ? 2.223   8.260   14.913  1.00 57.69  ? 63  ASN C CA   1 
ATOM   846  C  C    . ASN A 1 58  ? 1.266   9.442   15.076  1.00 56.52  ? 63  ASN C C    1 
ATOM   847  O  O    . ASN A 1 58  ? 0.089   9.303   14.697  1.00 56.67  ? 63  ASN C O    1 
ATOM   848  C  CB   . ASN A 1 58  ? 2.374   7.461   16.202  1.00 49.57  ? 63  ASN C CB   1 
ATOM   849  C  CG   . ASN A 1 58  ? 2.986   6.094   16.003  1.00 64.73  ? 63  ASN C CG   1 
ATOM   850  O  OD1  . ASN A 1 58  ? 2.848   5.483   14.939  1.00 67.31  ? 63  ASN C OD1  1 
ATOM   851  N  ND2  . ASN A 1 58  ? 3.655   5.587   17.027  1.00 70.45  ? 63  ASN C ND2  1 
ATOM   852  H  H    . ASN A 1 58  ? 4.225   8.693   14.966  1.00 64.13  ? 63  ASN C H    1 
ATOM   853  H  HA   . ASN A 1 58  ? 1.850   7.662   14.229  1.00 69.28  ? 63  ASN C HA   1 
ATOM   854  H  HB2  . ASN A 1 58  ? 2.934   7.968   16.825  1.00 59.53  ? 63  ASN C HB2  1 
ATOM   855  H  HB3  . ASN A 1 58  ? 1.493   7.355   16.613  1.00 59.53  ? 63  ASN C HB3  1 
ATOM   856  H  HD21 . ASN A 1 58  ? 3.653   6.008   17.808  1.00 84.59  ? 63  ASN C HD21 1 
ATOM   857  H  HD22 . ASN A 1 58  ? 4.113   4.834   16.931  1.00 84.59  ? 63  ASN C HD22 1 
ATOM   858  N  N    . LYS A 1 59  ? 1.759   10.572  15.577  1.00 52.30  ? 64  LYS C N    1 
ATOM   859  C  CA   . LYS A 1 59  ? 0.925   11.786  15.722  1.00 48.53  ? 64  LYS C CA   1 
ATOM   860  C  C    . LYS A 1 59  ? 0.502   12.266  14.330  1.00 55.29  ? 64  LYS C C    1 
ATOM   861  O  O    . LYS A 1 59  ? -0.669  12.620  14.171  1.00 58.44  ? 64  LYS C O    1 
ATOM   862  C  CB   . LYS A 1 59  ? 1.687   12.887  16.455  1.00 47.80  ? 64  LYS C CB   1 
ATOM   863  C  CG   . LYS A 1 59  ? 1.175   14.289  16.199  1.00 56.22  ? 64  LYS C CG   1 
ATOM   864  C  CD   . LYS A 1 59  ? 1.649   15.300  17.228  1.00 69.55  ? 64  LYS C CD   1 
ATOM   865  C  CE   . LYS A 1 59  ? 0.812   16.527  17.196  1.00 74.72  ? 64  LYS C CE   1 
ATOM   866  N  NZ   . LYS A 1 59  ? 0.652   17.060  18.547  1.00 80.38  ? 64  LYS C NZ   1 
ATOM   867  H  H    . LYS A 1 59  ? 2.621   10.640  15.833  1.00 62.80  ? 64  LYS C H    1 
ATOM   868  H  HA   . LYS A 1 59  ? 0.114   11.552  16.239  1.00 58.28  ? 64  LYS C HA   1 
ATOM   869  H  HB2  . LYS A 1 59  ? 1.644   12.712  17.418  1.00 57.40  ? 64  LYS C HB2  1 
ATOM   870  H  HB3  . LYS A 1 59  ? 2.629   12.848  16.186  1.00 57.40  ? 64  LYS C HB3  1 
ATOM   871  H  HG2  . LYS A 1 59  ? 1.474   14.579  15.310  1.00 67.51  ? 64  LYS C HG2  1 
ATOM   872  H  HG3  . LYS A 1 59  ? 0.194   14.271  16.200  1.00 67.51  ? 64  LYS C HG3  1 
ATOM   873  H  HD2  . LYS A 1 59  ? 1.600   14.899  18.122  1.00 83.50  ? 64  LYS C HD2  1 
ATOM   874  H  HD3  . LYS A 1 59  ? 2.582   15.538  17.043  1.00 83.50  ? 64  LYS C HD3  1 
ATOM   875  H  HE2  . LYS A 1 59  ? 1.230   17.200  16.630  1.00 89.70  ? 64  LYS C HE2  1 
ATOM   876  H  HE3  . LYS A 1 59  ? -0.065  16.317  16.830  1.00 89.70  ? 64  LYS C HE3  1 
ATOM   877  H  HZ1  . LYS A 1 59  ? 0.234   17.862  18.514  1.00 96.50  ? 64  LYS C HZ1  1 
ATOM   878  H  HZ2  . LYS A 1 59  ? 0.159   16.484  19.042  1.00 96.50  ? 64  LYS C HZ2  1 
ATOM   879  H  HZ3  . LYS A 1 59  ? 1.467   17.159  18.929  1.00 96.50  ? 64  LYS C HZ3  1 
ATOM   880  N  N    . PHE A 1 60  ? 1.424   12.287  13.373  1.00 52.19  ? 65  PHE C N    1 
ATOM   881  C  CA   . PHE A 1 60  ? 1.120   12.775  12.007  1.00 52.09  ? 65  PHE C CA   1 
ATOM   882  C  C    . PHE A 1 60  ? -0.008  11.942  11.434  1.00 53.64  ? 65  PHE C C    1 
ATOM   883  O  O    . PHE A 1 60  ? -0.962  12.525  10.916  1.00 55.85  ? 65  PHE C O    1 
ATOM   884  C  CB   . PHE A 1 60  ? 2.343   12.715  11.093  1.00 56.33  ? 65  PHE C CB   1 
ATOM   885  C  CG   . PHE A 1 60  ? 2.046   12.894  9.612   1.00 46.14  ? 65  PHE C CG   1 
ATOM   886  C  CD1  . PHE A 1 60  ? 1.885   14.157  9.062   1.00 47.12  ? 65  PHE C CD1  1 
ATOM   887  C  CD2  . PHE A 1 60  ? 1.938   11.794  8.775   1.00 60.74  ? 65  PHE C CD2  1 
ATOM   888  C  CE1  . PHE A 1 60  ? 1.620   14.313  7.712   1.00 53.26  ? 65  PHE C CE1  1 
ATOM   889  C  CE2  . PHE A 1 60  ? 1.674   11.955  7.426   1.00 56.75  ? 65  PHE C CE2  1 
ATOM   890  C  CZ   . PHE A 1 60  ? 1.515   13.213  6.898   1.00 51.63  ? 65  PHE C CZ   1 
ATOM   891  H  H    . PHE A 1 60  ? 2.267   12.001  13.520  1.00 62.68  ? 65  PHE C H    1 
ATOM   892  H  HA   . PHE A 1 60  ? 0.817   13.718  12.069  1.00 62.55  ? 65  PHE C HA   1 
ATOM   893  H  HB2  . PHE A 1 60  ? 2.973   13.412  11.375  1.00 67.64  ? 65  PHE C HB2  1 
ATOM   894  H  HB3  . PHE A 1 60  ? 2.783   11.847  11.223  1.00 67.64  ? 65  PHE C HB3  1 
ATOM   895  H  HD1  . PHE A 1 60  ? 1.957   14.917  9.616   1.00 56.59  ? 65  PHE C HD1  1 
ATOM   896  H  HD2  . PHE A 1 60  ? 2.043   10.926  9.133   1.00 72.93  ? 65  PHE C HD2  1 
ATOM   897  H  HE1  . PHE A 1 60  ? 1.511   15.178  7.349   1.00 63.95  ? 65  PHE C HE1  1 
ATOM   898  H  HE2  . PHE A 1 60  ? 1.597   11.197  6.870   1.00 68.15  ? 65  PHE C HE2  1 
ATOM   899  H  HZ   . PHE A 1 60  ? 1.331   13.322  5.978   1.00 62.00  ? 65  PHE C HZ   1 
ATOM   900  N  N    . GLN A 1 61  ? 0.083   10.622  11.541  1.00 52.07  ? 66  GLN C N    1 
ATOM   901  C  CA   . GLN A 1 61  ? -0.934  9.721   10.947  1.00 58.03  ? 66  GLN C CA   1 
ATOM   902  C  C    . GLN A 1 61  ? -2.303  9.997   11.594  1.00 62.08  ? 66  GLN C C    1 
ATOM   903  O  O    . GLN A 1 61  ? -3.296  10.026  10.855  1.00 58.62  ? 66  GLN C O    1 
ATOM   904  C  CB   . GLN A 1 61  ? -0.491  8.265   11.079  1.00 59.62  ? 66  GLN C CB   1 
ATOM   905  C  CG   . GLN A 1 61  ? 0.642   7.874   10.138  1.00 67.99  ? 66  GLN C CG   1 
ATOM   906  C  CD   . GLN A 1 61  ? 0.238   7.871   8.680   1.00 74.67  ? 66  GLN C CD   1 
ATOM   907  O  OE1  . GLN A 1 61  ? -0.794  7.313   8.295   1.00 82.75  ? 66  GLN C OE1  1 
ATOM   908  N  NE2  . GLN A 1 61  ? 1.058   8.497   7.851   1.00 75.33  ? 66  GLN C NE2  1 
ATOM   909  H  H    . GLN A 1 61  ? 0.762   10.231  11.988  1.00 62.52  ? 66  GLN C H    1 
ATOM   910  H  HA   . GLN A 1 61  ? -1.002  9.934   9.981   1.00 69.68  ? 66  GLN C HA   1 
ATOM   911  H  HB2  . GLN A 1 61  ? -0.200  8.111   12.003  1.00 71.58  ? 66  GLN C HB2  1 
ATOM   912  H  HB3  . GLN A 1 61  ? -1.262  7.684   10.911  1.00 71.58  ? 66  GLN C HB3  1 
ATOM   913  H  HG2  . GLN A 1 61  ? 1.388   8.500   10.255  1.00 81.63  ? 66  GLN C HG2  1 
ATOM   914  H  HG3  . GLN A 1 61  ? 0.965   6.979   10.376  1.00 81.63  ? 66  GLN C HG3  1 
ATOM   915  H  HE21 . GLN A 1 61  ? 1.709   9.004   8.175   1.00 90.44  ? 66  GLN C HE21 1 
ATOM   916  H  HE22 . GLN A 1 61  ? 0.955   8.414   6.975   1.00 90.44  ? 66  GLN C HE22 1 
ATOM   917  N  N    . LYS A 1 62  ? -2.341  10.234  12.900  1.00 51.55  ? 67  LYS C N    1 
ATOM   918  C  CA   . LYS A 1 62  ? -3.610  10.511  13.613  1.00 60.43  ? 67  LYS C CA   1 
ATOM   919  C  C    . LYS A 1 62  ? -4.180  11.850  13.138  1.00 60.76  ? 67  LYS C C    1 
ATOM   920  O  O    . LYS A 1 62  ? -5.384  11.901  12.855  1.00 62.93  ? 67  LYS C O    1 
ATOM   921  C  CB   . LYS A 1 62  ? -3.397  10.559  15.126  1.00 59.44  ? 67  LYS C CB   1 
ATOM   922  C  CG   . LYS A 1 62  ? -3.422  9.216   15.816  1.00 67.62  ? 67  LYS C CG   1 
ATOM   923  C  CD   . LYS A 1 62  ? -2.815  9.258   17.211  1.00 76.15  ? 67  LYS C CD   1 
ATOM   924  C  CE   . LYS A 1 62  ? -2.876  7.934   17.906  1.00 79.48  ? 67  LYS C CE   1 
ATOM   925  N  NZ   . LYS A 1 62  ? -1.831  7.795   18.923  1.00 80.57  ? 67  LYS C NZ   1 
ATOM   926  H  H    . LYS A 1 62  ? -1.591  10.246  13.400  1.00 61.90  ? 67  LYS C H    1 
ATOM   927  H  HA   . LYS A 1 62  ? -4.256  9.792   13.399  1.00 72.56  ? 67  LYS C HA   1 
ATOM   928  H  HB2  . LYS A 1 62  ? -2.530  10.981  15.305  1.00 71.38  ? 67  LYS C HB2  1 
ATOM   929  H  HB3  . LYS A 1 62  ? -4.091  11.126  15.523  1.00 71.38  ? 67  LYS C HB3  1 
ATOM   930  H  HG2  . LYS A 1 62  ? -4.352  8.910   15.877  1.00 81.19  ? 67  LYS C HG2  1 
ATOM   931  H  HG3  . LYS A 1 62  ? -2.923  8.573   15.267  1.00 81.19  ? 67  LYS C HG3  1 
ATOM   932  H  HD2  . LYS A 1 62  ? -1.877  9.543   17.141  1.00 91.43  ? 67  LYS C HD2  1 
ATOM   933  H  HD3  . LYS A 1 62  ? -3.297  9.925   17.746  1.00 91.43  ? 67  LYS C HD3  1 
ATOM   934  H  HE2  . LYS A 1 62  ? -3.745  7.831   18.333  1.00 95.42  ? 67  LYS C HE2  1 
ATOM   935  H  HE3  . LYS A 1 62  ? -2.773  7.221   17.251  1.00 95.42  ? 67  LYS C HE3  1 
ATOM   936  H  HZ1  . LYS A 1 62  ? -1.879  6.973   19.298  1.00 96.72  ? 67  LYS C HZ1  1 
ATOM   937  H  HZ2  . LYS A 1 62  ? -1.017  7.901   18.538  1.00 96.72  ? 67  LYS C HZ2  1 
ATOM   938  H  HZ3  . LYS A 1 62  ? -1.943  8.425   19.564  1.00 96.72  ? 67  LYS C HZ3  1 
ATOM   939  N  N    . ASP A 1 63  ? -3.345  12.882  13.061  1.00 56.05  ? 68  ASP C N    1 
ATOM   940  C  CA   . ASP A 1 63  ? -3.778  14.229  12.619  1.00 48.64  ? 68  ASP C CA   1 
ATOM   941  C  C    . ASP A 1 63  ? -4.333  14.135  11.196  1.00 56.82  ? 68  ASP C C    1 
ATOM   942  O  O    . ASP A 1 63  ? -5.379  14.747  10.935  1.00 51.46  ? 68  ASP C O    1 
ATOM   943  C  CB   . ASP A 1 63  ? -2.630  15.213  12.725  1.00 54.37  ? 68  ASP C CB   1 
ATOM   944  C  CG   . ASP A 1 63  ? -2.122  15.514  14.128  1.00 70.33  ? 68  ASP C CG   1 
ATOM   945  O  OD1  . ASP A 1 63  ? -2.710  14.993  15.097  1.00 65.07  ? 68  ASP C OD1  1 
ATOM   946  O  OD2  . ASP A 1 63  ? -1.133  16.266  14.239  1.00 62.70  ? 68  ASP C OD2  1 
ATOM   947  H  H    . ASP A 1 63  ? -2.469  12.790  13.250  1.00 67.30  ? 68  ASP C H    1 
ATOM   948  H  HA   . ASP A 1 63  ? -4.501  14.530  13.213  1.00 58.41  ? 68  ASP C HA   1 
ATOM   949  H  HB2  . ASP A 1 63  ? -1.881  14.850  12.208  1.00 65.29  ? 68  ASP C HB2  1 
ATOM   950  H  HB3  . ASP A 1 63  ? -2.905  16.054  12.306  1.00 65.29  ? 68  ASP C HB3  1 
ATOM   951  N  N    . LEU A 1 64  ? -3.672  13.376  10.327  1.00 53.67  ? 69  LEU C N    1 
ATOM   952  C  CA   . LEU A 1 64  ? -4.094  13.221  8.915   1.00 57.54  ? 69  LEU C CA   1 
ATOM   953  C  C    . LEU A 1 64  ? -5.448  12.502  8.882   1.00 61.78  ? 69  LEU C C    1 
ATOM   954  O  O    . LEU A 1 64  ? -6.342  12.978  8.170   1.00 55.30  ? 69  LEU C O    1 
ATOM   955  C  CB   . LEU A 1 64  ? -3.031  12.446  8.140   1.00 52.91  ? 69  LEU C CB   1 
ATOM   956  C  CG   . LEU A 1 64  ? -2.876  12.783  6.656   1.00 49.68  ? 69  LEU C CG   1 
ATOM   957  C  CD1  . LEU A 1 64  ? -2.293  14.163  6.450   1.00 62.90  ? 69  LEU C CD1  1 
ATOM   958  C  CD2  . LEU A 1 64  ? -1.987  11.748  6.017   1.00 57.98  ? 69  LEU C CD2  1 
ATOM   959  H  H    . LEU A 1 64  ? -2.943  12.907  10.575  1.00 64.44  ? 69  LEU C H    1 
ATOM   960  H  HA   . LEU A 1 64  ? -4.201  14.121  8.518   1.00 69.09  ? 69  LEU C HA   1 
ATOM   961  H  HB2  . LEU A 1 64  ? -2.163  12.595  8.578   1.00 63.54  ? 69  LEU C HB2  1 
ATOM   962  H  HB3  . LEU A 1 64  ? -3.236  11.487  8.218   1.00 63.54  ? 69  LEU C HB3  1 
ATOM   963  H  HG   . LEU A 1 64  ? -3.770  12.745  6.228   1.00 59.66  ? 69  LEU C HG   1 
ATOM   964  H  HD11 . LEU A 1 64  ? -1.878  14.211  5.572   1.00 75.52  ? 69  LEU C HD11 1 
ATOM   965  H  HD12 . LEU A 1 64  ? -3.000  14.827  6.512   1.00 75.52  ? 69  LEU C HD12 1 
ATOM   966  H  HD13 . LEU A 1 64  ? -1.624  14.336  7.134   1.00 75.52  ? 69  LEU C HD13 1 
ATOM   967  H  HD21 . LEU A 1 64  ? -2.107  11.766  5.053   1.00 69.62  ? 69  LEU C HD21 1 
ATOM   968  H  HD22 . LEU A 1 64  ? -1.060  11.944  6.231   1.00 69.62  ? 69  LEU C HD22 1 
ATOM   969  H  HD23 . LEU A 1 64  ? -2.217  10.868  6.357   1.00 69.62  ? 69  LEU C HD23 1 
ATOM   970  N  N    . MET A 1 65  ? -5.584  11.411  9.630   1.00 54.66  ? 70  MET C N    1 
ATOM   971  C  CA   . MET A 1 65  ? -6.826  10.603  9.640   1.00 58.16  ? 70  MET C CA   1 
ATOM   972  C  C    . MET A 1 65  ? -7.999  11.463  10.126  1.00 57.85  ? 70  MET C C    1 
ATOM   973  O  O    . MET A 1 65  ? -9.093  11.332  9.560   1.00 60.72  ? 70  MET C O    1 
ATOM   974  C  CB   . MET A 1 65  ? -6.660  9.386   10.548  1.00 63.70  ? 70  MET C CB   1 
ATOM   975  C  CG   . MET A 1 65  ? -5.998  8.205   9.874   1.00 70.14  ? 70  MET C CG   1 
ATOM   976  S  SD   . MET A 1 65  ? -6.133  8.300   8.080   1.00 96.11  ? 70  MET C SD   1 
ATOM   977  C  CE   . MET A 1 65  ? -7.907  8.055   7.917   1.00 73.43  ? 70  MET C CE   1 
ATOM   978  H  H    . MET A 1 65  ? -4.922  11.131  10.175  1.00 65.63  ? 70  MET C H    1 
ATOM   979  H  HA   . MET A 1 65  ? -7.012  10.305  8.714   1.00 69.83  ? 70  MET C HA   1 
ATOM   980  H  HB2  . MET A 1 65  ? -6.125  9.650   11.327  1.00 76.49  ? 70  MET C HB2  1 
ATOM   981  H  HB3  . MET A 1 65  ? -7.545  9.115   10.871  1.00 76.49  ? 70  MET C HB3  1 
ATOM   982  H  HG2  . MET A 1 65  ? -5.052  8.175   10.121  1.00 84.21  ? 70  MET C HG2  1 
ATOM   983  H  HG3  . MET A 1 65  ? -6.418  7.377   10.181  1.00 84.21  ? 70  MET C HG3  1 
ATOM   984  H  HE1  . MET A 1 65  ? -8.080  7.384   7.231   1.00 88.16  ? 70  MET C HE1  1 
ATOM   985  H  HE2  . MET A 1 65  ? -8.271  7.753   8.769   1.00 88.16  ? 70  MET C HE2  1 
ATOM   986  H  HE3  . MET A 1 65  ? -8.328  8.897   7.662   1.00 88.16  ? 70  MET C HE3  1 
ATOM   987  N  N    . ALA A 1 66  ? -7.775  12.323  11.110  1.00 50.70  ? 71  ALA C N    1 
ATOM   988  C  CA   . ALA A 1 66  ? -8.830  13.206  11.646  1.00 53.52  ? 71  ALA C CA   1 
ATOM   989  C  C    . ALA A 1 66  ? -9.290  14.179  10.568  1.00 55.20  ? 71  ALA C C    1 
ATOM   990  O  O    . ALA A 1 66  ? -10.501 14.321  10.373  1.00 57.78  ? 71  ALA C O    1 
ATOM   991  C  CB   . ALA A 1 66  ? -8.306  13.942  12.843  1.00 56.68  ? 71  ALA C CB   1 
ATOM   992  H  H    . ALA A 1 66  ? -6.967  12.428  11.498  1.00 60.88  ? 71  ALA C H    1 
ATOM   993  H  HA   . ALA A 1 66  ? -9.606  12.643  11.916  1.00 64.27  ? 71  ALA C HA   1 
ATOM   994  H  HB1  . ALA A 1 66  ? -8.965  14.589  13.143  1.00 68.06  ? 71  ALA C HB1  1 
ATOM   995  H  HB2  . ALA A 1 66  ? -8.122  13.311  13.558  1.00 68.06  ? 71  ALA C HB2  1 
ATOM   996  H  HB3  . ALA A 1 66  ? -7.485  14.404  12.605  1.00 68.06  ? 71  ALA C HB3  1 
ATOM   997  N  N    . LYS A 1 67  ? -8.349  14.827  9.891   1.00 53.71  ? 72  LYS C N    1 
ATOM   998  C  CA   . LYS A 1 67  ? -8.676  15.830  8.853   1.00 44.65  ? 72  LYS C CA   1 
ATOM   999  C  C    . LYS A 1 67  ? -9.441  15.163  7.709   1.00 44.56  ? 72  LYS C C    1 
ATOM   1000 O  O    . LYS A 1 67  ? -10.381 15.773  7.196   1.00 49.16  ? 72  LYS C O    1 
ATOM   1001 C  CB   . LYS A 1 67  ? -7.370  16.448  8.359   1.00 52.94  ? 72  LYS C CB   1 
ATOM   1002 C  CG   . LYS A 1 67  ? -6.738  17.425  9.322   1.00 59.66  ? 72  LYS C CG   1 
ATOM   1003 C  CD   . LYS A 1 67  ? -5.269  17.678  9.028   1.00 67.76  ? 72  LYS C CD   1 
ATOM   1004 C  CE   . LYS A 1 67  ? -4.830  18.976  9.604   1.00 67.59  ? 72  LYS C CE   1 
ATOM   1005 N  NZ   . LYS A 1 67  ? -3.415  18.945  9.975   1.00 78.22  ? 72  LYS C NZ   1 
ATOM   1006 H  H    . LYS A 1 67  ? -7.473  14.668  10.033  1.00 64.50  ? 72  LYS C H    1 
ATOM   1007 H  HA   . LYS A 1 67  ? -9.243  16.533  9.257   1.00 53.62  ? 72  LYS C HA   1 
ATOM   1008 H  HB2  . LYS A 1 67  ? -6.728  15.728  8.184   1.00 63.58  ? 72  LYS C HB2  1 
ATOM   1009 H  HB3  . LYS A 1 67  ? -7.540  16.910  7.511   1.00 63.58  ? 72  LYS C HB3  1 
ATOM   1010 H  HG2  . LYS A 1 67  ? -7.226  18.275  9.275   1.00 71.64  ? 72  LYS C HG2  1 
ATOM   1011 H  HG3  . LYS A 1 67  ? -6.827  17.072  10.233  1.00 71.64  ? 72  LYS C HG3  1 
ATOM   1012 H  HD2  . LYS A 1 67  ? -4.730  16.953  9.410   1.00 81.36  ? 72  LYS C HD2  1 
ATOM   1013 H  HD3  . LYS A 1 67  ? -5.130  17.690  8.056   1.00 81.36  ? 72  LYS C HD3  1 
ATOM   1014 H  HE2  . LYS A 1 67  ? -4.978  19.688  8.957   1.00 81.15  ? 72  LYS C HE2  1 
ATOM   1015 H  HE3  . LYS A 1 67  ? -5.361  19.166  10.397  1.00 81.15  ? 72  LYS C HE3  1 
ATOM   1016 H  HZ1  . LYS A 1 67  ? -3.207  19.679  10.461  1.00 93.91  ? 72  LYS C HZ1  1 
ATOM   1017 H  HZ2  . LYS A 1 67  ? -3.248  18.202  10.464  1.00 93.91  ? 72  LYS C HZ2  1 
ATOM   1018 H  HZ3  . LYS A 1 67  ? -2.909  18.929  9.224   1.00 93.91  ? 72  LYS C HZ3  1 
ATOM   1019 N  N    . ARG A 1 68  ? -9.046  13.955  7.339   1.00 45.75  ? 73  ARG C N    1 
ATOM   1020 C  CA   . ARG A 1 68  ? -9.699  13.219  6.236   1.00 54.69  ? 73  ARG C CA   1 
ATOM   1021 C  C    . ARG A 1 68  ? -11.153 12.920  6.611   1.00 54.32  ? 73  ARG C C    1 
ATOM   1022 O  O    . ARG A 1 68  ? -12.024 13.135  5.755   1.00 51.24  ? 73  ARG C O    1 
ATOM   1023 C  CB   . ARG A 1 68  ? -8.925  11.929  5.981   1.00 55.03  ? 73  ARG C CB   1 
ATOM   1024 C  CG   . ARG A 1 68  ? -7.740  12.085  5.046   1.00 58.65  ? 73  ARG C CG   1 
ATOM   1025 C  CD   . ARG A 1 68  ? -7.096  10.738  4.830   1.00 73.64  ? 73  ARG C CD   1 
ATOM   1026 N  NE   . ARG A 1 68  ? -5.760  10.693  5.426   1.00 78.31  ? 73  ARG C NE   1 
ATOM   1027 C  CZ   . ARG A 1 68  ? -4.697  10.206  4.812   1.00 83.97  ? 73  ARG C CZ   1 
ATOM   1028 N  NH1  . ARG A 1 68  ? -4.277  10.752  3.687   1.00 76.12  ? 73  ARG C NH1  1 
ATOM   1029 N  NH2  . ARG A 1 68  ? -4.054  9.179   5.328   1.00 83.16  ? 73  ARG C NH2  1 
ATOM   1030 H  H    . ARG A 1 68  ? -8.364  13.535  7.754   1.00 54.94  ? 73  ARG C H    1 
ATOM   1031 H  HA   . ARG A 1 68  ? -9.681  13.782  5.423   1.00 65.67  ? 73  ARG C HA   1 
ATOM   1032 H  HB2  . ARG A 1 68  ? -8.603  11.581  6.839   1.00 66.08  ? 73  ARG C HB2  1 
ATOM   1033 H  HB3  . ARG A 1 68  ? -9.539  11.265  5.603   1.00 66.08  ? 73  ARG C HB3  1 
ATOM   1034 H  HG2  . ARG A 1 68  ? -8.041  12.448  4.186   1.00 70.42  ? 73  ARG C HG2  1 
ATOM   1035 H  HG3  . ARG A 1 68  ? -7.085  12.699  5.443   1.00 70.42  ? 73  ARG C HG3  1 
ATOM   1036 H  HD2  . ARG A 1 68  ? -7.654  10.047  5.239   1.00 88.41  ? 73  ARG C HD2  1 
ATOM   1037 H  HD3  . ARG A 1 68  ? -7.031  10.553  3.872   1.00 88.41  ? 73  ARG C HD3  1 
ATOM   1038 H  HE   . ARG A 1 68  ? -5.657  11.009  6.232   1.00 94.02  ? 73  ARG C HE   1 
ATOM   1039 H  HH11 . ARG A 1 68  ? -4.804  11.300  3.239   1.00 91.39  ? 73  ARG C HH11 1 
ATOM   1040 H  HH12 . ARG A 1 68  ? -3.464  10.572  3.395   1.00 91.39  ? 73  ARG C HH12 1 
ATOM   1041 H  HH21 . ARG A 1 68  ? -3.984  9.110   6.207   1.00 99.84  ? 73  ARG C HH21 1 
ATOM   1042 H  HH22 . ARG A 1 68  ? -3.695  8.574   4.796   1.00 99.84  ? 73  ARG C HH22 1 
ATOM   1043 N  N    . THR A 1 69  ? -11.403 12.463  7.835   1.00 51.88  ? 74  THR C N    1 
ATOM   1044 C  CA   . THR A 1 69  ? -12.755 12.119  8.317   1.00 48.89  ? 74  THR C CA   1 
ATOM   1045 C  C    . THR A 1 69  ? -13.602 13.361  8.328   1.00 44.64  ? 74  THR C C    1 
ATOM   1046 O  O    . THR A 1 69  ? -14.757 13.279  7.909   1.00 50.29  ? 74  THR C O    1 
ATOM   1047 C  CB   . THR A 1 69  ? -12.652 11.482  9.700   1.00 51.88  ? 74  THR C CB   1 
ATOM   1048 O  OG1  . THR A 1 69  ? -12.034 10.217  9.492   1.00 51.53  ? 74  THR C OG1  1 
ATOM   1049 C  CG2  . THR A 1 69  ? -14.007 11.308  10.360  1.00 49.61  ? 74  THR C CG2  1 
ATOM   1050 H  H    . THR A 1 69  ? -10.768 12.342  8.464   1.00 62.30  ? 74  THR C H    1 
ATOM   1051 H  HA   . THR A 1 69  ? -13.152 11.469  7.699   1.00 58.71  ? 74  THR C HA   1 
ATOM   1052 H  HB   . THR A 1 69  ? -12.077 12.040  10.277  1.00 62.31  ? 74  THR C HB   1 
ATOM   1053 H  HG1  . THR A 1 69  ? -11.174 10.307  9.517   1.00 61.87  ? 74  THR C HG1  1 
ATOM   1054 H  HG21 . THR A 1 69  ? -13.955 10.602  11.024  1.00 59.58  ? 74  THR C HG21 1 
ATOM   1055 H  HG22 . THR A 1 69  ? -14.268 12.139  10.791  1.00 59.58  ? 74  THR C HG22 1 
ATOM   1056 H  HG23 . THR A 1 69  ? -14.668 11.071  9.687   1.00 59.58  ? 74  THR C HG23 1 
ATOM   1057 N  N    . ALA A 1 70  ? -13.043 14.487  8.743   1.00 48.20  ? 75  ALA C N    1 
ATOM   1058 C  CA   . ALA A 1 70  ? -13.783 15.755  8.861   1.00 46.59  ? 75  ALA C CA   1 
ATOM   1059 C  C    . ALA A 1 70  ? -14.197 16.278  7.488   1.00 54.46  ? 75  ALA C C    1 
ATOM   1060 O  O    . ALA A 1 70  ? -15.230 16.942  7.407   1.00 51.93  ? 75  ALA C O    1 
ATOM   1061 C  CB   . ALA A 1 70  ? -12.918 16.746  9.582   1.00 46.17  ? 75  ALA C CB   1 
ATOM   1062 H  H    . ALA A 1 70  ? -12.172 14.558  8.970   1.00 57.88  ? 75  ALA C H    1 
ATOM   1063 H  HA   . ALA A 1 70  ? -14.608 15.589  9.395   1.00 55.95  ? 75  ALA C HA   1 
ATOM   1064 H  HB1  . ALA A 1 70  ? -13.418 17.564  9.737   1.00 55.44  ? 75  ALA C HB1  1 
ATOM   1065 H  HB2  . ALA A 1 70  ? -12.636 16.372  10.433  1.00 55.44  ? 75  ALA C HB2  1 
ATOM   1066 H  HB3  . ALA A 1 70  ? -12.133 16.943  9.043   1.00 55.44  ? 75  ALA C HB3  1 
ATOM   1067 N  N    . GLU A 1 71  ? -13.400 16.016  6.462   1.00 51.58  ? 76  GLU C N    1 
ATOM   1068 C  CA   . GLU A 1 71  ? -13.695 16.488  5.091   1.00 46.86  ? 76  GLU C CA   1 
ATOM   1069 C  C    . GLU A 1 71  ? -14.716 15.550  4.445   1.00 44.17  ? 76  GLU C C    1 
ATOM   1070 O  O    . GLU A 1 71  ? -15.458 16.026  3.598   1.00 43.48  ? 76  GLU C O    1 
ATOM   1071 C  CB   . GLU A 1 71  ? -12.406 16.542  4.278   1.00 51.89  ? 76  GLU C CB   1 
ATOM   1072 C  CG   . GLU A 1 71  ? -12.028 17.954  3.846   1.00 68.33  ? 76  GLU C CG   1 
ATOM   1073 C  CD   . GLU A 1 71  ? -11.903 18.954  4.982   1.00 85.62  ? 76  GLU C CD   1 
ATOM   1074 O  OE1  . GLU A 1 71  ? -12.552 20.016  4.892   1.00 84.96  ? 76  GLU C OE1  1 
ATOM   1075 O  OE2  . GLU A 1 71  ? -11.172 18.672  5.953   1.00 78.18  ? 76  GLU C OE2  1 
ATOM   1076 H  H    . GLU A 1 71  ? -12.645 15.533  6.566   1.00 61.94  ? 76  GLU C H    1 
ATOM   1077 H  HA   . GLU A 1 71  ? -14.089 17.393  5.144   1.00 56.27  ? 76  GLU C HA   1 
ATOM   1078 H  HB2  . GLU A 1 71  ? -11.678 16.160  4.809   1.00 62.31  ? 76  GLU C HB2  1 
ATOM   1079 H  HB3  . GLU A 1 71  ? -12.516 15.984  3.481   1.00 62.31  ? 76  GLU C HB3  1 
ATOM   1080 H  HG2  . GLU A 1 71  ? -11.174 17.920  3.368   1.00 82.04  ? 76  GLU C HG2  1 
ATOM   1081 H  HG3  . GLU A 1 71  ? -12.706 18.283  3.219   1.00 82.04  ? 76  GLU C HG3  1 
ATOM   1082 N  N    . PHE A 1 72  ? -14.713 14.273  4.814   1.00 46.80  ? 77  PHE C N    1 
ATOM   1083 C  CA   . PHE A 1 72  ? -15.678 13.280  4.284   1.00 44.15  ? 77  PHE C CA   1 
ATOM   1084 C  C    . PHE A 1 72  ? -17.038 13.551  4.891   1.00 45.76  ? 77  PHE C C    1 
ATOM   1085 O  O    . PHE A 1 72  ? -17.993 13.381  4.173   1.00 46.79  ? 77  PHE C O    1 
ATOM   1086 C  CB   . PHE A 1 72  ? -15.244 11.858  4.628   1.00 45.77  ? 77  PHE C CB   1 
ATOM   1087 C  CG   . PHE A 1 72  ? -16.199 10.781  4.140   1.00 49.26  ? 77  PHE C CG   1 
ATOM   1088 C  CD1  . PHE A 1 72  ? -16.115 10.289  2.845   1.00 51.78  ? 77  PHE C CD1  1 
ATOM   1089 C  CD2  . PHE A 1 72  ? -17.182 10.270  4.976   1.00 54.10  ? 77  PHE C CD2  1 
ATOM   1090 C  CE1  . PHE A 1 72  ? -16.986 9.309   2.402   1.00 50.81  ? 77  PHE C CE1  1 
ATOM   1091 C  CE2  . PHE A 1 72  ? -18.050 9.291   4.527   1.00 50.82  ? 77  PHE C CE2  1 
ATOM   1092 C  CZ   . PHE A 1 72  ? -17.948 8.812   3.243   1.00 55.61  ? 77  PHE C CZ   1 
ATOM   1093 H  H    . PHE A 1 72  ? -14.120 13.959  5.416   1.00 56.21  ? 77  PHE C H    1 
ATOM   1094 H  HA   . PHE A 1 72  ? -15.735 13.373  3.297   1.00 53.03  ? 77  PHE C HA   1 
ATOM   1095 H  HB2  . PHE A 1 72  ? -14.358 11.700  4.234   1.00 54.97  ? 77  PHE C HB2  1 
ATOM   1096 H  HB3  . PHE A 1 72  ? -15.157 11.788  5.604   1.00 54.97  ? 77  PHE C HB3  1 
ATOM   1097 H  HD1  . PHE A 1 72  ? -15.454 10.626  2.263   1.00 62.18  ? 77  PHE C HD1  1 
ATOM   1098 H  HD2  . PHE A 1 72  ? -17.256 10.595  5.860   1.00 64.96  ? 77  PHE C HD2  1 
ATOM   1099 H  HE1  . PHE A 1 72  ? -16.917 8.983   1.518   1.00 61.01  ? 77  PHE C HE1  1 
ATOM   1100 H  HE2  . PHE A 1 72  ? -18.713 8.951   5.104   1.00 61.02  ? 77  PHE C HE2  1 
ATOM   1101 H  HZ   . PHE A 1 72  ? -18.544 8.147   2.937   1.00 66.77  ? 77  PHE C HZ   1 
ATOM   1102 N  N    . ASN A 1 73  ? -17.104 13.860  6.181   1.00 45.70  ? 78  ASN C N    1 
ATOM   1103 C  CA   . ASN A 1 73  ? -18.368 14.169  6.894   1.00 48.27  ? 78  ASN C CA   1 
ATOM   1104 C  C    . ASN A 1 73  ? -18.938 15.474  6.345   1.00 47.95  ? 78  ASN C C    1 
ATOM   1105 O  O    . ASN A 1 73  ? -20.162 15.561  6.207   1.00 46.60  ? 78  ASN C O    1 
ATOM   1106 C  CB   . ASN A 1 73  ? -18.153 14.224  8.399   1.00 43.77  ? 78  ASN C CB   1 
ATOM   1107 C  CG   . ASN A 1 73  ? -17.711 12.907  8.985   1.00 42.41  ? 78  ASN C CG   1 
ATOM   1108 O  OD1  . ASN A 1 73  ? -18.046 11.839  8.465   1.00 46.19  ? 78  ASN C OD1  1 
ATOM   1109 N  ND2  . ASN A 1 73  ? -16.951 12.966  10.065  1.00 50.95  ? 78  ASN C ND2  1 
ATOM   1110 H  H    . ASN A 1 73  ? -16.353 13.859  6.680   1.00 54.88  ? 78  ASN C H    1 
ATOM   1111 H  HA   . ASN A 1 73  ? -19.012 13.450  6.708   1.00 57.97  ? 78  ASN C HA   1 
ATOM   1112 H  HB2  . ASN A 1 73  ? -17.475 14.901  8.595   1.00 52.57  ? 78  ASN C HB2  1 
ATOM   1113 H  HB3  . ASN A 1 73  ? -18.986 14.501  8.829   1.00 52.57  ? 78  ASN C HB3  1 
ATOM   1114 H  HD21 . ASN A 1 73  ? -17.091 12.409  10.740  1.00 61.18  ? 78  ASN C HD21 1 
ATOM   1115 H  HD22 . ASN A 1 73  ? -16.291 13.560  10.104  1.00 61.18  ? 78  ASN C HD22 1 
ATOM   1116 N  N    . LYS A 1 74  ? -18.078 16.432  6.023   1.00 47.50  ? 79  LYS C N    1 
ATOM   1117 C  CA   . LYS A 1 74  ? -18.520 17.725  5.458   1.00 44.59  ? 79  LYS C CA   1 
ATOM   1118 C  C    . LYS A 1 74  ? -19.187 17.495  4.098   1.00 50.96  ? 79  LYS C C    1 
ATOM   1119 O  O    . LYS A 1 74  ? -20.267 18.062  3.872   1.00 42.92  ? 79  LYS C O    1 
ATOM   1120 C  CB   . LYS A 1 74  ? -17.334 18.675  5.304   1.00 56.12  ? 79  LYS C CB   1 
ATOM   1121 C  CG   . LYS A 1 74  ? -17.651 19.962  4.574   1.00 56.22  ? 79  LYS C CG   1 
ATOM   1122 C  CD   . LYS A 1 74  ? -16.781 21.120  5.031   1.00 64.49  ? 79  LYS C CD   1 
ATOM   1123 C  CE   . LYS A 1 74  ? -17.154 22.390  4.356   1.00 73.78  ? 79  LYS C CE   1 
ATOM   1124 N  NZ   . LYS A 1 74  ? -16.764 22.371  2.946   1.00 89.52  ? 79  LYS C NZ   1 
ATOM   1125 H  H    . LYS A 1 74  ? -17.189 16.326  6.135   1.00 57.04  ? 79  LYS C H    1 
ATOM   1126 H  HA   . LYS A 1 74  ? -19.180 18.129  6.075   1.00 53.56  ? 79  LYS C HA   1 
ATOM   1127 H  HB2  . LYS A 1 74  ? -16.992 18.900  6.195   1.00 67.39  ? 79  LYS C HB2  1 
ATOM   1128 H  HB3  . LYS A 1 74  ? -16.620 18.212  4.820   1.00 67.39  ? 79  LYS C HB3  1 
ATOM   1129 H  HG2  . LYS A 1 74  ? -17.523 19.820  3.611   1.00 67.50  ? 79  LYS C HG2  1 
ATOM   1130 H  HG3  . LYS A 1 74  ? -18.594 20.189  4.727   1.00 67.50  ? 79  LYS C HG3  1 
ATOM   1131 H  HD2  . LYS A 1 74  ? -16.875 21.229  6.001   1.00 77.43  ? 79  LYS C HD2  1 
ATOM   1132 H  HD3  . LYS A 1 74  ? -15.842 20.913  4.832   1.00 77.43  ? 79  LYS C HD3  1 
ATOM   1133 H  HE2  . LYS A 1 74  ? -18.117 22.517  4.419   1.00 88.58  ? 79  LYS C HE2  1 
ATOM   1134 H  HE3  . LYS A 1 74  ? -16.715 23.137  4.800   1.00 88.58  ? 79  LYS C HE3  1 
ATOM   1135 H  HZ1  . LYS A 1 74  ? -16.673 23.218  2.640   1.00 107.46 ? 79  LYS C HZ1  1 
ATOM   1136 H  HZ2  . LYS A 1 74  ? -15.977 21.933  2.857   1.00 107.46 ? 79  LYS C HZ2  1 
ATOM   1137 H  HZ3  . LYS A 1 74  ? -17.398 21.944  2.459   1.00 107.46 ? 79  LYS C HZ3  1 
ATOM   1138 N  N    . LYS A 1 75  ? -18.568 16.694  3.239   1.00 40.29  ? 80  LYS C N    1 
ATOM   1139 C  CA   . LYS A 1 75  ? -19.111 16.428  1.885   1.00 47.01  ? 80  LYS C CA   1 
ATOM   1140 C  C    . LYS A 1 75  ? -20.425 15.649  1.992   1.00 46.51  ? 80  LYS C C    1 
ATOM   1141 O  O    . LYS A 1 75  ? -21.356 15.984  1.259   1.00 47.67  ? 80  LYS C O    1 
ATOM   1142 C  CB   . LYS A 1 75  ? -18.106 15.642  1.043   1.00 45.73  ? 80  LYS C CB   1 
ATOM   1143 C  CG   . LYS A 1 75  ? -18.547 15.357  -0.382  1.00 57.51  ? 80  LYS C CG   1 
ATOM   1144 C  CD   . LYS A 1 75  ? -19.072 16.586  -1.113  1.00 66.46  ? 80  LYS C CD   1 
ATOM   1145 C  CE   . LYS A 1 75  ? -19.104 16.408  -2.586  1.00 73.79  ? 80  LYS C CE   1 
ATOM   1146 N  NZ   . LYS A 1 75  ? -19.945 17.436  -3.200  1.00 75.58  ? 80  LYS C NZ   1 
ATOM   1147 H  H    . LYS A 1 75  ? -17.801 16.272  3.455   1.00 48.39  ? 80  LYS C H    1 
ATOM   1148 H  HA   . LYS A 1 75  ? -19.295 17.300  1.452   1.00 56.46  ? 80  LYS C HA   1 
ATOM   1149 H  HB2  . LYS A 1 75  ? -17.264 16.143  1.013   1.00 54.92  ? 80  LYS C HB2  1 
ATOM   1150 H  HB3  . LYS A 1 75  ? -17.928 14.787  1.489   1.00 54.92  ? 80  LYS C HB3  1 
ATOM   1151 H  HG2  . LYS A 1 75  ? -17.785 14.992  -0.879  1.00 69.06  ? 80  LYS C HG2  1 
ATOM   1152 H  HG3  . LYS A 1 75  ? -19.249 14.670  -0.363  1.00 69.06  ? 80  LYS C HG3  1 
ATOM   1153 H  HD2  . LYS A 1 75  ? -19.980 16.783  -0.801  1.00 79.80  ? 80  LYS C HD2  1 
ATOM   1154 H  HD3  . LYS A 1 75  ? -18.504 17.355  -0.894  1.00 79.80  ? 80  LYS C HD3  1 
ATOM   1155 H  HE2  . LYS A 1 75  ? -18.202 16.471  -2.944  1.00 88.60  ? 80  LYS C HE2  1 
ATOM   1156 H  HE3  . LYS A 1 75  ? -19.463 15.529  -2.797  1.00 88.60  ? 80  LYS C HE3  1 
ATOM   1157 H  HZ1  . LYS A 1 75  ? -19.924 17.353  -4.101  1.00 90.73  ? 80  LYS C HZ1  1 
ATOM   1158 H  HZ2  . LYS A 1 75  ? -20.798 17.340  -2.909  1.00 90.73  ? 80  LYS C HZ2  1 
ATOM   1159 H  HZ3  . LYS A 1 75  ? -19.642 18.255  -2.963  1.00 90.73  ? 80  LYS C HZ3  1 
ATOM   1160 N  N    . ALA A 1 76  ? -20.497 14.658  2.871   1.00 38.81  ? 81  ALA C N    1 
ATOM   1161 C  CA   . ALA A 1 76  ? -21.707 13.829  3.046   1.00 42.16  ? 81  ALA C CA   1 
ATOM   1162 C  C    . ALA A 1 76  ? -22.884 14.721  3.429   1.00 48.44  ? 81  ALA C C    1 
ATOM   1163 O  O    . ALA A 1 76  ? -23.969 14.544  2.870   1.00 37.96  ? 81  ALA C O    1 
ATOM   1164 C  CB   . ALA A 1 76  ? -21.449 12.785  4.087   1.00 40.59  ? 81  ALA C CB   1 
ATOM   1165 H  H    . ALA A 1 76  ? -19.818 14.444  3.423   1.00 46.62  ? 81  ALA C H    1 
ATOM   1166 H  HA   . ALA A 1 76  ? -21.915 13.385  2.177   1.00 50.63  ? 81  ALA C HA   1 
ATOM   1167 H  HB1  . ALA A 1 76  ? -22.281 12.346  4.321   1.00 48.75  ? 81  ALA C HB1  1 
ATOM   1168 H  HB2  . ALA A 1 76  ? -20.823 12.127  3.740   1.00 48.75  ? 81  ALA C HB2  1 
ATOM   1169 H  HB3  . ALA A 1 76  ? -21.069 13.202  4.878   1.00 48.75  ? 81  ALA C HB3  1 
ATOM   1170 N  N    . ASP A 1 77  ? -22.655 15.674  4.329   1.00 44.18  ? 82  ASP C N    1 
ATOM   1171 C  CA   . ASP A 1 77  ? -23.739 16.564  4.816   1.00 49.18  ? 82  ASP C CA   1 
ATOM   1172 C  C    . ASP A 1 77  ? -24.178 17.500  3.697   1.00 43.90  ? 82  ASP C C    1 
ATOM   1173 O  O    . ASP A 1 77  ? -25.381 17.723  3.566   1.00 44.94  ? 82  ASP C O    1 
ATOM   1174 C  CB   . ASP A 1 77  ? -23.325 17.353  6.042   1.00 42.89  ? 82  ASP C CB   1 
ATOM   1175 C  CG   . ASP A 1 77  ? -24.401 18.298  6.556   1.00 64.79  ? 82  ASP C CG   1 
ATOM   1176 O  OD1  . ASP A 1 77  ? -25.463 17.797  6.980   1.00 60.42  ? 82  ASP C OD1  1 
ATOM   1177 O  OD2  . ASP A 1 77  ? -24.186 19.524  6.492   1.00 56.15  ? 82  ASP C OD2  1 
ATOM   1178 H  H    . ASP A 1 77  ? -21.831 15.818  4.667   1.00 53.06  ? 82  ASP C H    1 
ATOM   1179 H  HA   . ASP A 1 77  ? -24.506 16.005  5.067   1.00 59.07  ? 82  ASP C HA   1 
ATOM   1180 H  HB2  . ASP A 1 77  ? -23.086 16.724  6.753   1.00 51.51  ? 82  ASP C HB2  1 
ATOM   1181 H  HB3  . ASP A 1 77  ? -22.528 17.876  5.815   1.00 51.51  ? 82  ASP C HB3  1 
ATOM   1182 N  N    . GLU A 1 78  ? -23.230 18.010  2.926   1.00 44.34  ? 83  GLU C N    1 
ATOM   1183 C  CA   . GLU A 1 78  ? -23.540 18.910  1.795   1.00 43.98  ? 83  GLU C CA   1 
ATOM   1184 C  C    . GLU A 1 78  ? -24.381 18.159  0.759   1.00 39.52  ? 83  GLU C C    1 
ATOM   1185 O  O    . GLU A 1 78  ? -25.372 18.726  0.298   1.00 43.47  ? 83  GLU C O    1 
ATOM   1186 C  CB   . GLU A 1 78  ? -22.232 19.403  1.187   1.00 51.00  ? 83  GLU C CB   1 
ATOM   1187 C  CG   . GLU A 1 78  ? -21.596 20.541  1.974   1.00 66.91  ? 83  GLU C CG   1 
ATOM   1188 C  CD   . GLU A 1 78  ? -20.201 20.927  1.517   1.00 79.85  ? 83  GLU C CD   1 
ATOM   1189 O  OE1  . GLU A 1 78  ? -19.606 21.801  2.174   1.00 72.71  ? 83  GLU C OE1  1 
ATOM   1190 O  OE2  . GLU A 1 78  ? -19.709 20.369  0.514   1.00 81.69  ? 83  GLU C OE2  1 
ATOM   1191 H  H    . GLU A 1 78  ? -22.359 17.819  3.062   1.00 53.25  ? 83  GLU C H    1 
ATOM   1192 H  HA   . GLU A 1 78  ? -24.058 19.682  2.136   1.00 52.82  ? 83  GLU C HA   1 
ATOM   1193 H  HB2  . GLU A 1 78  ? -21.606 18.651  1.148   1.00 61.25  ? 83  GLU C HB2  1 
ATOM   1194 H  HB3  . GLU A 1 78  ? -22.405 19.697  0.268   1.00 61.25  ? 83  GLU C HB3  1 
ATOM   1195 H  HG2  . GLU A 1 78  ? -22.173 21.331  1.910   1.00 80.33  ? 83  GLU C HG2  1 
ATOM   1196 H  HG3  . GLU A 1 78  ? -21.552 20.286  2.919   1.00 80.33  ? 83  GLU C HG3  1 
ATOM   1197 N  N    . ASN A 1 79  ? -24.006 16.925  0.443   1.00 45.74  ? 84  ASN C N    1 
ATOM   1198 C  CA   . ASN A 1 79  ? -24.711 16.106  -0.578  1.00 43.87  ? 84  ASN C CA   1 
ATOM   1199 C  C    . ASN A 1 79  ? -26.124 15.788  -0.079  1.00 41.05  ? 84  ASN C C    1 
ATOM   1200 O  O    . ASN A 1 79  ? -27.059 15.885  -0.873  1.00 38.22  ? 84  ASN C O    1 
ATOM   1201 C  CB   . ASN A 1 79  ? -23.892 14.869  -0.921  1.00 39.21  ? 84  ASN C CB   1 
ATOM   1202 C  CG   . ASN A 1 79  ? -22.634 15.168  -1.701  1.00 44.13  ? 84  ASN C CG   1 
ATOM   1203 O  OD1  . ASN A 1 79  ? -22.556 16.170  -2.417  1.00 41.77  ? 84  ASN C OD1  1 
ATOM   1204 N  ND2  . ASN A 1 79  ? -21.642 14.300  -1.586  1.00 39.46  ? 84  ASN C ND2  1 
ATOM   1205 H  H    . ASN A 1 79  ? -23.307 16.528  0.852   1.00 54.94  ? 84  ASN C H    1 
ATOM   1206 H  HA   . ASN A 1 79  ? -24.796 16.644  -1.395  1.00 52.69  ? 84  ASN C HA   1 
ATOM   1207 H  HB2  . ASN A 1 79  ? -23.647 14.420  -0.088  1.00 47.09  ? 84  ASN C HB2  1 
ATOM   1208 H  HB3  . ASN A 1 79  ? -24.447 14.256  -1.440  1.00 47.09  ? 84  ASN C HB3  1 
ATOM   1209 H  HD21 . ASN A 1 79  ? -21.175 14.058  -2.300  1.00 47.39  ? 84  ASN C HD21 1 
ATOM   1210 H  HD22 . ASN A 1 79  ? -21.445 13.959  -0.789  1.00 47.39  ? 84  ASN C HD22 1 
ATOM   1211 N  N    . LYS A 1 80  ? -26.268 15.461  1.196   1.00 37.94  ? 85  LYS C N    1 
ATOM   1212 C  CA   . LYS A 1 80  ? -27.598 15.185  1.785   1.00 43.38  ? 85  LYS C CA   1 
ATOM   1213 C  C    . LYS A 1 80  ? -28.484 16.433  1.640   1.00 42.02  ? 85  LYS C C    1 
ATOM   1214 O  O    . LYS A 1 80  ? -29.606 16.280  1.171   1.00 47.66  ? 85  LYS C O    1 
ATOM   1215 C  CB   . LYS A 1 80  ? -27.450 14.735  3.238   1.00 41.65  ? 85  LYS C CB   1 
ATOM   1216 C  CG   . LYS A 1 80  ? -28.752 14.354  3.906   1.00 50.78  ? 85  LYS C CG   1 
ATOM   1217 C  CD   . LYS A 1 80  ? -28.660 13.090  4.746   1.00 61.13  ? 85  LYS C CD   1 
ATOM   1218 C  CE   . LYS A 1 80  ? -28.425 11.855  3.943   1.00 62.63  ? 85  LYS C CE   1 
ATOM   1219 N  NZ   . LYS A 1 80  ? -29.479 11.644  2.951   1.00 62.21  ? 85  LYS C NZ   1 
ATOM   1220 H  H    . LYS A 1 80  ? -25.560 15.403  1.753   1.00 45.58  ? 85  LYS C H    1 
ATOM   1221 H  HA   . LYS A 1 80  ? -28.011 14.448  1.281   1.00 52.10  ? 85  LYS C HA   1 
ATOM   1222 H  HB2  . LYS A 1 80  ? -26.841 13.967  3.268   1.00 50.02  ? 85  LYS C HB2  1 
ATOM   1223 H  HB3  . LYS A 1 80  ? -27.037 15.461  3.751   1.00 50.02  ? 85  LYS C HB3  1 
ATOM   1224 H  HG2  . LYS A 1 80  ? -29.039 15.099  4.478   1.00 60.98  ? 85  LYS C HG2  1 
ATOM   1225 H  HG3  . LYS A 1 80  ? -29.435 14.232  3.212   1.00 60.98  ? 85  LYS C HG3  1 
ATOM   1226 H  HD2  . LYS A 1 80  ? -27.927 13.193  5.390   1.00 73.40  ? 85  LYS C HD2  1 
ATOM   1227 H  HD3  . LYS A 1 80  ? -29.495 12.986  5.251   1.00 73.40  ? 85  LYS C HD3  1 
ATOM   1228 H  HE2  . LYS A 1 80  ? -27.571 11.924  3.483   1.00 75.19  ? 85  LYS C HE2  1 
ATOM   1229 H  HE3  . LYS A 1 80  ? -28.386 11.085  4.536   1.00 75.19  ? 85  LYS C HE3  1 
ATOM   1230 H  HZ1  . LYS A 1 80  ? -29.581 10.757  2.796   1.00 74.70  ? 85  LYS C HZ1  1 
ATOM   1231 H  HZ2  . LYS A 1 80  ? -30.258 11.990  3.253   1.00 74.70  ? 85  LYS C HZ2  1 
ATOM   1232 H  HZ3  . LYS A 1 80  ? -29.249 12.053  2.174   1.00 74.70  ? 85  LYS C HZ3  1 
ATOM   1233 N  N    . VAL A 1 81  ? -27.982 17.613  1.986   1.00 41.58  ? 86  VAL C N    1 
ATOM   1234 C  CA   . VAL A 1 81  ? -28.775 18.876  1.936   1.00 40.90  ? 86  VAL C CA   1 
ATOM   1235 C  C    . VAL A 1 81  ? -29.202 19.144  0.489   1.00 38.54  ? 86  VAL C C    1 
ATOM   1236 O  O    . VAL A 1 81  ? -30.374 19.462  0.273   1.00 40.76  ? 86  VAL C O    1 
ATOM   1237 C  CB   . VAL A 1 81  ? -27.975 20.053  2.524   1.00 45.98  ? 86  VAL C CB   1 
ATOM   1238 C  CG1  . VAL A 1 81  ? -28.652 21.389  2.262   1.00 43.29  ? 86  VAL C CG1  1 
ATOM   1239 C  CG2  . VAL A 1 81  ? -27.716 19.871  4.012   1.00 45.86  ? 86  VAL C CG2  1 
ATOM   1240 H  H    . VAL A 1 81  ? -27.124 17.699  2.252   1.00 49.94  ? 86  VAL C H    1 
ATOM   1241 H  HA   . VAL A 1 81  ? -29.578 18.752  2.475   1.00 49.13  ? 86  VAL C HA   1 
ATOM   1242 H  HB   . VAL A 1 81  ? -27.102 20.064  2.067   1.00 55.22  ? 86  VAL C HB   1 
ATOM   1243 H  HG11 . VAL A 1 81  ? -28.317 22.050  2.891   1.00 51.99  ? 86  VAL C HG11 1 
ATOM   1244 H  HG12 . VAL A 1 81  ? -28.460 21.681  1.355   1.00 51.99  ? 86  VAL C HG12 1 
ATOM   1245 H  HG13 . VAL A 1 81  ? -29.613 21.294  2.376   1.00 51.99  ? 86  VAL C HG13 1 
ATOM   1246 H  HG21 . VAL A 1 81  ? -26.763 19.944  4.187   1.00 55.08  ? 86  VAL C HG21 1 
ATOM   1247 H  HG22 . VAL A 1 81  ? -28.190 20.557  4.509   1.00 55.08  ? 86  VAL C HG22 1 
ATOM   1248 H  HG23 . VAL A 1 81  ? -28.030 18.995  4.291   1.00 55.08  ? 86  VAL C HG23 1 
ATOM   1249 N  N    . LYS A 1 82  ? -28.285 19.009  -0.454  1.00 38.97  ? 87  LYS C N    1 
ATOM   1250 C  CA   . LYS A 1 82  ? -28.595 19.202  -1.889  1.00 40.85  ? 87  LYS C CA   1 
ATOM   1251 C  C    . LYS A 1 82  ? -29.681 18.214  -2.325  1.00 42.57  ? 87  LYS C C    1 
ATOM   1252 O  O    . LYS A 1 82  ? -30.593 18.630  -3.042  1.00 48.97  ? 87  LYS C O    1 
ATOM   1253 C  CB   . LYS A 1 82  ? -27.340 18.968  -2.728  1.00 38.74  ? 87  LYS C CB   1 
ATOM   1254 C  CG   . LYS A 1 82  ? -26.269 20.025  -2.630  1.00 51.72  ? 87  LYS C CG   1 
ATOM   1255 C  CD   . LYS A 1 82  ? -24.900 19.451  -2.952  1.00 57.18  ? 87  LYS C CD   1 
ATOM   1256 C  CE   . LYS A 1 82  ? -23.835 20.482  -2.875  1.00 71.61  ? 87  LYS C CE   1 
ATOM   1257 N  NZ   . LYS A 1 82  ? -23.116 20.560  -4.146  1.00 95.00  ? 87  LYS C NZ   1 
ATOM   1258 H  H    . LYS A 1 82  ? -27.436 18.779  -0.255  1.00 46.81  ? 87  LYS C H    1 
ATOM   1259 H  HA   . LYS A 1 82  ? -28.921 20.126  -2.023  1.00 49.06  ? 87  LYS C HA   1 
ATOM   1260 H  HB2  . LYS A 1 82  ? -26.947 18.112  -2.458  1.00 46.54  ? 87  LYS C HB2  1 
ATOM   1261 H  HB3  . LYS A 1 82  ? -27.607 18.887  -3.668  1.00 46.54  ? 87  LYS C HB3  1 
ATOM   1262 H  HG2  . LYS A 1 82  ? -26.476 20.750  -3.257  1.00 62.10  ? 87  LYS C HG2  1 
ATOM   1263 H  HG3  . LYS A 1 82  ? -26.264 20.391  -1.720  1.00 62.10  ? 87  LYS C HG3  1 
ATOM   1264 H  HD2  . LYS A 1 82  ? -24.696 18.727  -2.322  1.00 68.65  ? 87  LYS C HD2  1 
ATOM   1265 H  HD3  . LYS A 1 82  ? -24.916 19.074  -3.857  1.00 68.65  ? 87  LYS C HD3  1 
ATOM   1266 H  HE2  . LYS A 1 82  ? -24.236 21.347  -2.678  1.00 85.97  ? 87  LYS C HE2  1 
ATOM   1267 H  HE3  . LYS A 1 82  ? -23.210 20.258  -2.162  1.00 85.97  ? 87  LYS C HE3  1 
ATOM   1268 H  HZ1  . LYS A 1 82  ? -22.512 21.234  -4.117  1.00 114.04 ? 87  LYS C HZ1  1 
ATOM   1269 H  HZ2  . LYS A 1 82  ? -22.687 19.777  -4.297  1.00 114.04 ? 87  LYS C HZ2  1 
ATOM   1270 H  HZ3  . LYS A 1 82  ? -23.705 20.712  -4.816  1.00 114.04 ? 87  LYS C HZ3  1 
ATOM   1271 N  N    . GLY A 1 83  ? -29.582 16.958  -1.901  1.00 41.52  ? 88  GLY C N    1 
ATOM   1272 C  CA   . GLY A 1 83  ? -30.552 15.921  -2.274  1.00 39.24  ? 88  GLY C CA   1 
ATOM   1273 C  C    . GLY A 1 83  ? -31.923 16.243  -1.746  1.00 38.48  ? 88  GLY C C    1 
ATOM   1274 O  O    . GLY A 1 83  ? -32.876 16.157  -2.527  1.00 40.27  ? 88  GLY C O    1 
ATOM   1275 H  H    . GLY A 1 83  ? -28.914 16.699  -1.349  1.00 49.87  ? 88  GLY C H    1 
ATOM   1276 H  HA2  . GLY A 1 83  ? -30.586 15.847  -3.257  1.00 47.13  ? 88  GLY C HA2  1 
ATOM   1277 H  HA3  . GLY A 1 83  ? -30.255 15.054  -1.914  1.00 47.13  ? 88  GLY C HA3  1 
ATOM   1278 N  N    . GLU A 1 84  ? -32.020 16.623  -0.478  1.00 35.61  ? 89  GLU C N    1 
ATOM   1279 C  CA   . GLU A 1 84  ? -33.333 16.887  0.158   1.00 42.81  ? 89  GLU C CA   1 
ATOM   1280 C  C    . GLU A 1 84  ? -33.977 18.071  -0.565  1.00 39.86  ? 89  GLU C C    1 
ATOM   1281 O  O    . GLU A 1 84  ? -35.181 18.033  -0.787  1.00 38.43  ? 89  GLU C O    1 
ATOM   1282 C  CB   . GLU A 1 84  ? -33.234 17.177  1.652   1.00 42.76  ? 89  GLU C CB   1 
ATOM   1283 C  CG   . GLU A 1 84  ? -32.397 16.166  2.430   1.00 59.93  ? 89  GLU C CG   1 
ATOM   1284 C  CD   . GLU A 1 84  ? -33.039 15.602  3.682   1.00 75.87  ? 89  GLU C CD   1 
ATOM   1285 O  OE1  . GLU A 1 84  ? -32.741 16.127  4.773   1.00 80.91  ? 89  GLU C OE1  1 
ATOM   1286 O  OE2  . GLU A 1 84  ? -33.819 14.634  3.571   1.00 76.92  ? 89  GLU C OE2  1 
ATOM   1287 H  H    . GLU A 1 84  ? -31.286 16.764  0.026   1.00 42.77  ? 89  GLU C H    1 
ATOM   1288 H  HA   . GLU A 1 84  ? -33.905 16.090  0.030   1.00 51.41  ? 89  GLU C HA   1 
ATOM   1289 H  HB2  . GLU A 1 84  ? -32.839 18.066  1.769   1.00 51.35  ? 89  GLU C HB2  1 
ATOM   1290 H  HB3  . GLU A 1 84  ? -34.137 17.200  2.028   1.00 51.35  ? 89  GLU C HB3  1 
ATOM   1291 H  HG2  . GLU A 1 84  ? -32.173 15.418  1.838   1.00 71.96  ? 89  GLU C HG2  1 
ATOM   1292 H  HG3  . GLU A 1 84  ? -31.557 16.595  2.693   1.00 71.96  ? 89  GLU C HG3  1 
ATOM   1293 N  N    . ALA A 1 85  ? -33.184 19.053  -0.959  1.00 36.82  ? 90  ALA C N    1 
ATOM   1294 C  CA   . ALA A 1 85  ? -33.685 20.237  -1.681  1.00 44.96  ? 90  ALA C CA   1 
ATOM   1295 C  C    . ALA A 1 85  ? -34.224 19.831  -3.051  1.00 41.93  ? 90  ALA C C    1 
ATOM   1296 O  O    . ALA A 1 85  ? -35.325 20.262  -3.390  1.00 45.47  ? 90  ALA C O    1 
ATOM   1297 C  CB   . ALA A 1 85  ? -32.573 21.237  -1.787  1.00 41.60  ? 90  ALA C CB   1 
ATOM   1298 H  H    . ALA A 1 85  ? -32.293 19.052  -0.817  1.00 44.23  ? 90  ALA C H    1 
ATOM   1299 H  HA   . ALA A 1 85  ? -34.432 20.631  -1.157  1.00 54.00  ? 90  ALA C HA   1 
ATOM   1300 H  HB1  . ALA A 1 85  ? -32.907 22.054  -2.191  1.00 49.97  ? 90  ALA C HB1  1 
ATOM   1301 H  HB2  . ALA A 1 85  ? -32.225 21.433  -0.901  1.00 49.97  ? 90  ALA C HB2  1 
ATOM   1302 H  HB3  . ALA A 1 85  ? -31.859 20.874  -2.338  1.00 49.97  ? 90  ALA C HB3  1 
ATOM   1303 N  N    . PHE A 1 86  ? -33.486 19.010  -3.793  1.00 41.51  ? 91  PHE C N    1 
ATOM   1304 C  CA   . PHE A 1 86  ? -33.890 18.578  -5.154  1.00 35.82  ? 91  PHE C CA   1 
ATOM   1305 C  C    . PHE A 1 86  ? -35.202 17.842  -5.072  1.00 37.22  ? 91  PHE C C    1 
ATOM   1306 O  O    . PHE A 1 86  ? -36.098 18.161  -5.845  1.00 38.79  ? 91  PHE C O    1 
ATOM   1307 C  CB   . PHE A 1 86  ? -32.798 17.697  -5.760  1.00 37.56  ? 91  PHE C CB   1 
ATOM   1308 C  CG   . PHE A 1 86  ? -33.220 16.872  -6.964  1.00 36.36  ? 91  PHE C CG   1 
ATOM   1309 C  CD1  . PHE A 1 86  ? -33.197 17.415  -8.240  1.00 41.78  ? 91  PHE C CD1  1 
ATOM   1310 C  CD2  . PHE A 1 86  ? -33.624 15.553  -6.817  1.00 37.21  ? 91  PHE C CD2  1 
ATOM   1311 C  CE1  . PHE A 1 86  ? -33.572 16.659  -9.336  1.00 41.87  ? 91  PHE C CE1  1 
ATOM   1312 C  CE2  . PHE A 1 86  ? -33.998 14.803  -7.917  1.00 36.97  ? 91  PHE C CE2  1 
ATOM   1313 C  CZ   . PHE A 1 86  ? -33.972 15.358  -9.172  1.00 40.21  ? 91  PHE C CZ   1 
ATOM   1314 H  H    . PHE A 1 86  ? -32.709 18.669  -3.486  1.00 49.86  ? 91  PHE C H    1 
ATOM   1315 H  HA   . PHE A 1 86  ? -34.007 19.382  -5.724  1.00 43.02  ? 91  PHE C HA   1 
ATOM   1316 H  HB2  . PHE A 1 86  ? -32.047 18.273  -6.023  1.00 45.12  ? 91  PHE C HB2  1 
ATOM   1317 H  HB3  . PHE A 1 86  ? -32.472 17.087  -5.062  1.00 45.12  ? 91  PHE C HB3  1 
ATOM   1318 H  HD1  . PHE A 1 86  ? -32.922 18.309  -8.359  1.00 50.18  ? 91  PHE C HD1  1 
ATOM   1319 H  HD2  . PHE A 1 86  ? -33.644 15.166  -5.956  1.00 44.69  ? 91  PHE C HD2  1 
ATOM   1320 H  HE1  . PHE A 1 86  ? -33.554 17.041  -10.198 1.00 50.29  ? 91  PHE C HE1  1 
ATOM   1321 H  HE2  . PHE A 1 86  ? -34.275 13.907  -7.803  1.00 44.41  ? 91  PHE C HE2  1 
ATOM   1322 H  HZ   . PHE A 1 86  ? -34.229 14.844  -9.921  1.00 48.29  ? 91  PHE C HZ   1 
ATOM   1323 N  N    . LEU A 1 87  ? -35.317 16.909  -4.137  1.00 35.98  ? 92  LEU C N    1 
ATOM   1324 C  CA   . LEU A 1 87  ? -36.528 16.066  -4.011  1.00 41.97  ? 92  LEU C CA   1 
ATOM   1325 C  C    . LEU A 1 87  ? -37.705 16.906  -3.492  1.00 43.77  ? 92  LEU C C    1 
ATOM   1326 O  O    . LEU A 1 87  ? -38.836 16.602  -3.885  1.00 38.92  ? 92  LEU C O    1 
ATOM   1327 C  CB   . LEU A 1 87  ? -36.189 14.878  -3.116  1.00 34.75  ? 92  LEU C CB   1 
ATOM   1328 C  CG   . LEU A 1 87  ? -35.214 13.858  -3.709  1.00 43.30  ? 92  LEU C CG   1 
ATOM   1329 C  CD1  . LEU A 1 87  ? -34.719 12.910  -2.643  1.00 41.64  ? 92  LEU C CD1  1 
ATOM   1330 C  CD2  . LEU A 1 87  ? -35.834 13.088  -4.855  1.00 39.12  ? 92  LEU C CD2  1 
ATOM   1331 H  H    . LEU A 1 87  ? -34.659 16.760  -3.538  1.00 43.22  ? 92  LEU C H    1 
ATOM   1332 H  HA   . LEU A 1 87  ? -36.764 15.731  -4.912  1.00 50.41  ? 92  LEU C HA   1 
ATOM   1333 H  HB2  . LEU A 1 87  ? -35.802 15.227  -2.280  1.00 41.74  ? 92  LEU C HB2  1 
ATOM   1334 H  HB3  . LEU A 1 87  ? -37.028 14.412  -2.893  1.00 41.74  ? 92  LEU C HB3  1 
ATOM   1335 H  HG   . LEU A 1 87  ? -34.430 14.351  -4.064  1.00 52.00  ? 92  LEU C HG   1 
ATOM   1336 H  HD11 . LEU A 1 87  ? -33.924 12.449  -2.963  1.00 50.01  ? 92  LEU C HD11 1 
ATOM   1337 H  HD12 . LEU A 1 87  ? -34.500 13.412  -1.840  1.00 50.01  ? 92  LEU C HD12 1 
ATOM   1338 H  HD13 . LEU A 1 87  ? -35.412 12.259  -2.441  1.00 50.01  ? 92  LEU C HD13 1 
ATOM   1339 H  HD21 . LEU A 1 87  ? -35.248 12.356  -5.108  1.00 46.99  ? 92  LEU C HD21 1 
ATOM   1340 H  HD22 . LEU A 1 87  ? -36.695 12.733  -4.578  1.00 46.99  ? 92  LEU C HD22 1 
ATOM   1341 H  HD23 . LEU A 1 87  ? -35.958 13.681  -5.616  1.00 46.99  ? 92  LEU C HD23 1 
ATOM   1342 N  N    . THR A 1 88  ? -37.450 17.940  -2.689  1.00 39.69  ? 93  THR C N    1 
ATOM   1343 C  CA   . THR A 1 88  ? -38.496 18.836  -2.161  1.00 35.62  ? 93  THR C CA   1 
ATOM   1344 C  C    . THR A 1 88  ? -39.041 19.668  -3.300  1.00 39.73  ? 93  THR C C    1 
ATOM   1345 O  O    . THR A 1 88  ? -40.241 19.926  -3.306  1.00 53.02  ? 93  THR C O    1 
ATOM   1346 C  CB   . THR A 1 88  ? -37.936 19.686  -1.025  1.00 43.55  ? 93  THR C CB   1 
ATOM   1347 O  OG1  . THR A 1 88  ? -37.805 18.813  0.088   1.00 39.01  ? 93  THR C OG1  1 
ATOM   1348 C  CG2  . THR A 1 88  ? -38.856 20.831  -0.649  1.00 46.14  ? 93  THR C CG2  1 
ATOM   1349 H  H    . THR A 1 88  ? -36.623 18.170  -2.414  1.00 47.67  ? 93  THR C H    1 
ATOM   1350 H  HA   . THR A 1 88  ? -39.223 18.283  -1.803  1.00 42.79  ? 93  THR C HA   1 
ATOM   1351 H  HB   . THR A 1 88  ? -37.050 20.042  -1.275  1.00 52.30  ? 93  THR C HB   1 
ATOM   1352 H  HG1  . THR A 1 88  ? -37.131 18.287  -0.030  1.00 46.86  ? 93  THR C HG1  1 
ATOM   1353 H  HG21 . THR A 1 88  ? -38.655 21.122  0.255   1.00 55.41  ? 93  THR C HG21 1 
ATOM   1354 H  HG22 . THR A 1 88  ? -38.722 21.572  -1.265  1.00 55.41  ? 93  THR C HG22 1 
ATOM   1355 H  HG23 . THR A 1 88  ? -39.781 20.533  -0.695  1.00 55.41  ? 93  THR C HG23 1 
ATOM   1356 N  N    . GLU A 1 89  ? -38.210 20.058  -4.253  1.00 42.26  ? 94  GLU C N    1 
ATOM   1357 C  CA   . GLU A 1 89  ? -38.661 20.817  -5.444  1.00 45.91  ? 94  GLU C CA   1 
ATOM   1358 C  C    . GLU A 1 89  ? -39.290 19.879  -6.485  1.00 44.40  ? 94  GLU C C    1 
ATOM   1359 O  O    . GLU A 1 89  ? -40.272 20.297  -7.114  1.00 46.99  ? 94  GLU C O    1 
ATOM   1360 C  CB   . GLU A 1 89  ? -37.465 21.548  -6.043  1.00 46.37  ? 94  GLU C CB   1 
ATOM   1361 C  CG   . GLU A 1 89  ? -37.852 22.732  -6.921  1.00 65.47  ? 94  GLU C CG   1 
ATOM   1362 C  CD   . GLU A 1 89  ? -36.781 23.139  -7.915  1.00 82.99  ? 94  GLU C CD   1 
ATOM   1363 O  OE1  . GLU A 1 89  ? -35.584 23.065  -7.566  1.00 88.05  ? 94  GLU C OE1  1 
ATOM   1364 O  OE2  . GLU A 1 89  ? -37.144 23.535  -9.040  1.00 86.76  ? 94  GLU C OE2  1 
ATOM   1365 H  H    . GLU A 1 89  ? -37.329 19.866  -4.215  1.00 50.76  ? 94  GLU C H    1 
ATOM   1366 H  HA   . GLU A 1 89  ? -39.336 21.484  -5.162  1.00 55.14  ? 94  GLU C HA   1 
ATOM   1367 H  HB2  . GLU A 1 89  ? -36.891 21.859  -5.313  1.00 55.69  ? 94  GLU C HB2  1 
ATOM   1368 H  HB3  . GLU A 1 89  ? -36.948 20.910  -6.577  1.00 55.69  ? 94  GLU C HB3  1 
ATOM   1369 H  HG2  . GLU A 1 89  ? -38.667 22.510  -7.416  1.00 78.61  ? 94  GLU C HG2  1 
ATOM   1370 H  HG3  . GLU A 1 89  ? -38.053 23.500  -6.347  1.00 78.61  ? 94  GLU C HG3  1 
ATOM   1371 N  N    . ASN A 1 90  ? -38.779 18.659  -6.640  1.00 44.45  ? 95  ASN C N    1 
ATOM   1372 C  CA   . ASN A 1 90  ? -39.238 17.716  -7.697  1.00 38.93  ? 95  ASN C CA   1 
ATOM   1373 C  C    . ASN A 1 90  ? -40.674 17.258  -7.452  1.00 39.55  ? 95  ASN C C    1 
ATOM   1374 O  O    . ASN A 1 90  ? -41.372 16.997  -8.430  1.00 40.51  ? 95  ASN C O    1 
ATOM   1375 C  CB   . ASN A 1 90  ? -38.311 16.513  -7.790  1.00 31.09  ? 95  ASN C CB   1 
ATOM   1376 C  CG   . ASN A 1 90  ? -38.513 15.717  -9.052  1.00 41.22  ? 95  ASN C CG   1 
ATOM   1377 O  OD1  . ASN A 1 90  ? -38.401 16.270  -10.148 1.00 40.10  ? 95  ASN C OD1  1 
ATOM   1378 N  ND2  . ASN A 1 90  ? -38.793 14.430  -8.923  1.00 36.47  ? 95  ASN C ND2  1 
ATOM   1379 H  H    . ASN A 1 90  ? -38.136 18.348  -6.090  1.00 53.39  ? 95  ASN C H    1 
ATOM   1380 H  HA   . ASN A 1 90  ? -39.202 18.187  -8.559  1.00 46.76  ? 95  ASN C HA   1 
ATOM   1381 H  HB2  . ASN A 1 90  ? -37.385 16.823  -7.757  1.00 37.35  ? 95  ASN C HB2  1 
ATOM   1382 H  HB3  . ASN A 1 90  ? -38.463 15.936  -7.018  1.00 37.35  ? 95  ASN C HB3  1 
ATOM   1383 H  HD21 . ASN A 1 90  ? -39.346 14.038  -9.494  1.00 43.81  ? 95  ASN C HD21 1 
ATOM   1384 H  HD22 . ASN A 1 90  ? -38.432 13.963  -8.260  1.00 43.81  ? 95  ASN C HD22 1 
ATOM   1385 N  N    . LYS A 1 91  ? -41.092 17.167  -6.201  1.00 42.10  ? 96  LYS C N    1 
ATOM   1386 C  CA   . LYS A 1 91  ? -42.444 16.669  -5.850  1.00 40.32  ? 96  LYS C CA   1 
ATOM   1387 C  C    . LYS A 1 91  ? -43.529 17.648  -6.320  1.00 43.33  ? 96  LYS C C    1 
ATOM   1388 O  O    . LYS A 1 91  ? -44.682 17.240  -6.398  1.00 45.00  ? 96  LYS C O    1 
ATOM   1389 C  CB   . LYS A 1 91  ? -42.544 16.449  -4.341  1.00 40.44  ? 96  LYS C CB   1 
ATOM   1390 C  CG   . LYS A 1 91  ? -42.190 17.640  -3.482  1.00 50.01  ? 96  LYS C CG   1 
ATOM   1391 C  CD   . LYS A 1 91  ? -43.044 17.777  -2.236  1.00 64.45  ? 96  LYS C CD   1 
ATOM   1392 C  CE   . LYS A 1 91  ? -42.456 18.767  -1.294  1.00 67.77  ? 96  LYS C CE   1 
ATOM   1393 N  NZ   . LYS A 1 91  ? -42.675 20.135  -1.765  1.00 68.17  ? 96  LYS C NZ   1 
ATOM   1394 H  H    . LYS A 1 91  ? -40.550 17.391  -5.516  1.00 50.56  ? 96  LYS C H    1 
ATOM   1395 H  HA   . LYS A 1 91  ? -42.583 15.800  -6.304  1.00 48.42  ? 96  LYS C HA   1 
ATOM   1396 H  HB2  . LYS A 1 91  ? -43.461 16.178  -4.125  1.00 48.57  ? 96  LYS C HB2  1 
ATOM   1397 H  HB3  . LYS A 1 91  ? -41.951 15.706  -4.097  1.00 48.57  ? 96  LYS C HB3  1 
ATOM   1398 H  HG2  . LYS A 1 91  ? -41.251 17.557  -3.213  1.00 60.06  ? 96  LYS C HG2  1 
ATOM   1399 H  HG3  . LYS A 1 91  ? -42.278 18.455  -4.020  1.00 60.06  ? 96  LYS C HG3  1 
ATOM   1400 H  HD2  . LYS A 1 91  ? -43.945 18.068  -2.492  1.00 77.39  ? 96  LYS C HD2  1 
ATOM   1401 H  HD3  . LYS A 1 91  ? -43.111 16.905  -1.791  1.00 77.39  ? 96  LYS C HD3  1 
ATOM   1402 H  HE2  . LYS A 1 91  ? -42.860 18.661  -0.415  1.00 81.37  ? 96  LYS C HE2  1 
ATOM   1403 H  HE3  . LYS A 1 91  ? -41.498 18.607  -1.214  1.00 81.37  ? 96  LYS C HE3  1 
ATOM   1404 H  HZ1  . LYS A 1 91  ? -42.873 20.675  -1.067  1.00 81.85  ? 96  LYS C HZ1  1 
ATOM   1405 H  HZ2  . LYS A 1 91  ? -41.925 20.440  -2.170  1.00 81.85  ? 96  LYS C HZ2  1 
ATOM   1406 H  HZ3  . LYS A 1 91  ? -43.360 20.148  -2.356  1.00 81.85  ? 96  LYS C HZ3  1 
ATOM   1407 N  N    . ASN A 1 92  ? -43.174 18.890  -6.618  1.00 47.66  ? 97  ASN C N    1 
ATOM   1408 C  CA   . ASN A 1 92  ? -44.152 19.918  -7.061  1.00 51.45  ? 97  ASN C CA   1 
ATOM   1409 C  C    . ASN A 1 92  ? -44.243 19.919  -8.587  1.00 47.39  ? 97  ASN C C    1 
ATOM   1410 O  O    . ASN A 1 92  ? -45.048 20.703  -9.106  1.00 50.78  ? 97  ASN C O    1 
ATOM   1411 C  CB   . ASN A 1 92  ? -43.783 21.291  -6.517  1.00 52.12  ? 97  ASN C CB   1 
ATOM   1412 C  CG   . ASN A 1 92  ? -43.535 21.265  -5.031  1.00 56.44  ? 97  ASN C CG   1 
ATOM   1413 O  OD1  . ASN A 1 92  ? -44.471 21.085  -4.246  1.00 63.57  ? 97  ASN C OD1  1 
ATOM   1414 N  ND2  . ASN A 1 92  ? -42.283 21.421  -4.634  1.00 64.29  ? 97  ASN C ND2  1 
ATOM   1415 H  H    . ASN A 1 92  ? -42.320 19.170  -6.541  1.00 57.24  ? 97  ASN C H    1 
ATOM   1416 H  HA   . ASN A 1 92  ? -45.034 19.689  -6.698  1.00 61.79  ? 97  ASN C HA   1 
ATOM   1417 H  HB2  . ASN A 1 92  ? -42.976 21.607  -6.970  1.00 62.59  ? 97  ASN C HB2  1 
ATOM   1418 H  HB3  . ASN A 1 92  ? -44.506 21.919  -6.710  1.00 62.59  ? 97  ASN C HB3  1 
ATOM   1419 H  HD21 . ASN A 1 92  ? -42.075 22.054  -4.051  1.00 77.19  ? 97  ASN C HD21 1 
ATOM   1420 H  HD22 . ASN A 1 92  ? -41.655 20.875  -4.945  1.00 77.19  ? 97  ASN C HD22 1 
ATOM   1421 N  N    . LYS A 1 93  ? -43.490 19.061  -9.270  1.00 40.85  ? 98  LYS C N    1 
ATOM   1422 C  CA   . LYS A 1 93  ? -43.428 19.083  -10.752 1.00 40.99  ? 98  LYS C CA   1 
ATOM   1423 C  C    . LYS A 1 93  ? -44.457 18.122  -11.379 1.00 43.12  ? 98  LYS C C    1 
ATOM   1424 O  O    . LYS A 1 93  ? -44.833 17.135  -10.736 1.00 44.37  ? 98  LYS C O    1 
ATOM   1425 C  CB   . LYS A 1 93  ? -41.972 18.826  -11.140 1.00 44.54  ? 98  LYS C CB   1 
ATOM   1426 C  CG   . LYS A 1 93  ? -41.007 19.755  -10.441 1.00 45.87  ? 98  LYS C CG   1 
ATOM   1427 C  CD   . LYS A 1 93  ? -39.819 20.166  -11.290 1.00 53.05  ? 98  LYS C CD   1 
ATOM   1428 C  CE   . LYS A 1 93  ? -38.795 20.848  -10.459 1.00 57.03  ? 98  LYS C CE   1 
ATOM   1429 N  NZ   . LYS A 1 93  ? -37.608 21.109  -11.270 1.00 64.96  ? 98  LYS C NZ   1 
ATOM   1430 H  H    . LYS A 1 93  ? -42.983 18.439  -8.860  1.00 49.07  ? 98  LYS C H    1 
ATOM   1431 H  HA   . LYS A 1 93  ? -43.636 20.000  -11.041 1.00 49.24  ? 98  LYS C HA   1 
ATOM   1432 H  HB2  . LYS A 1 93  ? -41.739 17.900  -10.917 1.00 53.49  ? 98  LYS C HB2  1 
ATOM   1433 H  HB3  . LYS A 1 93  ? -41.872 18.938  -12.109 1.00 53.49  ? 98  LYS C HB3  1 
ATOM   1434 H  HG2  . LYS A 1 93  ? -41.494 20.561  -10.165 1.00 55.09  ? 98  LYS C HG2  1 
ATOM   1435 H  HG3  . LYS A 1 93  ? -40.680 19.313  -9.630  1.00 55.09  ? 98  LYS C HG3  1 
ATOM   1436 H  HD2  . LYS A 1 93  ? -39.423 19.369  -11.703 1.00 63.70  ? 98  LYS C HD2  1 
ATOM   1437 H  HD3  . LYS A 1 93  ? -40.120 20.773  -11.999 1.00 63.70  ? 98  LYS C HD3  1 
ATOM   1438 H  HE2  . LYS A 1 93  ? -39.148 21.689  -10.119 1.00 68.48  ? 98  LYS C HE2  1 
ATOM   1439 H  HE3  . LYS A 1 93  ? -38.557 20.284  -9.701  1.00 68.48  ? 98  LYS C HE3  1 
ATOM   1440 H  HZ1  . LYS A 1 93  ? -37.046 21.661  -10.822 1.00 78.00  ? 98  LYS C HZ1  1 
ATOM   1441 H  HZ2  . LYS A 1 93  ? -37.186 20.327  -11.445 1.00 78.00  ? 98  LYS C HZ2  1 
ATOM   1442 H  HZ3  . LYS A 1 93  ? -37.855 21.496  -12.050 1.00 78.00  ? 98  LYS C HZ3  1 
ATOM   1443 N  N    . PRO A 1 94  ? -44.925 18.387  -12.615 1.00 46.01  ? 99  PRO C N    1 
ATOM   1444 C  CA   . PRO A 1 94  ? -45.940 17.558  -13.252 1.00 42.10  ? 99  PRO C CA   1 
ATOM   1445 C  C    . PRO A 1 94  ? -45.594 16.089  -13.441 1.00 32.32  ? 99  PRO C C    1 
ATOM   1446 O  O    . PRO A 1 94  ? -44.490 15.794  -13.901 1.00 42.72  ? 99  PRO C O    1 
ATOM   1447 C  CB   . PRO A 1 94  ? -46.094 18.266  -14.607 1.00 40.24  ? 99  PRO C CB   1 
ATOM   1448 C  CG   . PRO A 1 94  ? -45.678 19.676  -14.348 1.00 53.00  ? 99  PRO C CG   1 
ATOM   1449 C  CD   . PRO A 1 94  ? -44.484 19.481  -13.462 1.00 55.82  ? 99  PRO C CD   1 
ATOM   1450 H  HA   . PRO A 1 94  ? -46.783 17.638  -12.742 1.00 50.56  ? 99  PRO C HA   1 
ATOM   1451 H  HB2  . PRO A 1 94  ? -45.516 17.851  -15.287 1.00 48.34  ? 99  PRO C HB2  1 
ATOM   1452 H  HB3  . PRO A 1 94  ? -47.028 18.227  -14.917 1.00 48.34  ? 99  PRO C HB3  1 
ATOM   1453 H  HG2  . PRO A 1 94  ? -45.435 20.136  -15.177 1.00 63.64  ? 99  PRO C HG2  1 
ATOM   1454 H  HG3  . PRO A 1 94  ? -46.383 20.178  -13.889 1.00 63.64  ? 99  PRO C HG3  1 
ATOM   1455 H  HD2  . PRO A 1 94  ? -43.690 19.231  -13.983 1.00 67.03  ? 99  PRO C HD2  1 
ATOM   1456 H  HD3  . PRO A 1 94  ? -44.298 20.293  -12.946 1.00 67.03  ? 99  PRO C HD3  1 
ATOM   1457 N  N    . GLY A 1 95  ? -46.506 15.192  -13.077 1.00 39.81  ? 100 GLY C N    1 
ATOM   1458 C  CA   . GLY A 1 95  ? -46.318 13.740  -13.247 1.00 33.93  ? 100 GLY C CA   1 
ATOM   1459 C  C    . GLY A 1 95  ? -45.551 13.081  -12.118 1.00 39.61  ? 100 GLY C C    1 
ATOM   1460 O  O    . GLY A 1 95  ? -45.490 11.852  -12.116 1.00 34.77  ? 100 GLY C O    1 
ATOM   1461 H  H    . GLY A 1 95  ? -47.288 15.444  -12.700 1.00 47.82  ? 100 GLY C H    1 
ATOM   1462 H  HA2  . GLY A 1 95  ? -47.203 13.316  -13.321 1.00 40.76  ? 100 GLY C HA2  1 
ATOM   1463 H  HA3  . GLY A 1 95  ? -45.842 13.579  -14.095 1.00 40.76  ? 100 GLY C HA3  1 
ATOM   1464 N  N    . VAL A 1 96  ? -44.993 13.837  -11.179 1.00 36.99  ? 101 VAL C N    1 
ATOM   1465 C  CA   . VAL A 1 96  ? -44.122 13.240  -10.126 1.00 38.90  ? 101 VAL C CA   1 
ATOM   1466 C  C    . VAL A 1 96  ? -44.995 12.575  -9.053  1.00 30.18  ? 101 VAL C C    1 
ATOM   1467 O  O    . VAL A 1 96  ? -45.888 13.247  -8.544  1.00 35.38  ? 101 VAL C O    1 
ATOM   1468 C  CB   . VAL A 1 96  ? -43.125 14.252  -9.535  1.00 35.19  ? 101 VAL C CB   1 
ATOM   1469 C  CG1  . VAL A 1 96  ? -42.314 13.651  -8.395  1.00 37.64  ? 101 VAL C CG1  1 
ATOM   1470 C  CG2  . VAL A 1 96  ? -42.207 14.811  -10.613 1.00 28.60  ? 101 VAL C CG2  1 
ATOM   1471 H  H    . VAL A 1 96  ? -45.124 14.728  -11.135 1.00 44.43  ? 101 VAL C H    1 
ATOM   1472 H  HA   . VAL A 1 96  ? -43.593 12.537  -10.549 1.00 46.72  ? 101 VAL C HA   1 
ATOM   1473 H  HB   . VAL A 1 96  ? -43.652 15.000  -9.169  1.00 42.27  ? 101 VAL C HB   1 
ATOM   1474 H  HG11 . VAL A 1 96  ? -41.509 14.178  -8.255  1.00 45.21  ? 101 VAL C HG11 1 
ATOM   1475 H  HG12 . VAL A 1 96  ? -42.844 13.654  -7.580  1.00 45.21  ? 101 VAL C HG12 1 
ATOM   1476 H  HG13 . VAL A 1 96  ? -42.067 12.737  -8.617  1.00 45.21  ? 101 VAL C HG13 1 
ATOM   1477 H  HG21 . VAL A 1 96  ? -41.291 14.815  -10.291 1.00 34.36  ? 101 VAL C HG21 1 
ATOM   1478 H  HG22 . VAL A 1 96  ? -42.266 14.256  -11.409 1.00 34.36  ? 101 VAL C HG22 1 
ATOM   1479 H  HG23 . VAL A 1 96  ? -42.476 15.719  -10.832 1.00 34.36  ? 101 VAL C HG23 1 
ATOM   1480 N  N    . VAL A 1 97  ? -44.764 11.293  -8.783  1.00 36.43  ? 102 VAL C N    1 
ATOM   1481 C  CA   . VAL A 1 97  ? -45.471 10.519  -7.723  1.00 28.51  ? 102 VAL C CA   1 
ATOM   1482 C  C    . VAL A 1 97  ? -44.448 10.198  -6.626  1.00 36.70  ? 102 VAL C C    1 
ATOM   1483 O  O    . VAL A 1 97  ? -43.377 9.706   -6.981  1.00 33.61  ? 102 VAL C O    1 
ATOM   1484 C  CB   . VAL A 1 97  ? -46.101 9.245   -8.299  1.00 38.86  ? 102 VAL C CB   1 
ATOM   1485 C  CG1  . VAL A 1 97  ? -46.528 8.265   -7.215  1.00 35.55  ? 102 VAL C CG1  1 
ATOM   1486 C  CG2  . VAL A 1 97  ? -47.252 9.577   -9.234  1.00 43.03  ? 102 VAL C CG2  1 
ATOM   1487 H  H    . VAL A 1 97  ? -44.146 10.823  -9.240  1.00 43.76  ? 102 VAL C H    1 
ATOM   1488 H  HA   . VAL A 1 97  ? -46.177 11.071  -7.340  1.00 34.26  ? 102 VAL C HA   1 
ATOM   1489 H  HB   . VAL A 1 97  ? -45.404 8.804   -8.839  1.00 46.67  ? 102 VAL C HB   1 
ATOM   1490 H  HG11 . VAL A 1 97  ? -47.117 7.593   -7.597  1.00 42.70  ? 102 VAL C HG11 1 
ATOM   1491 H  HG12 . VAL A 1 97  ? -45.742 7.829   -6.842  1.00 42.70  ? 102 VAL C HG12 1 
ATOM   1492 H  HG13 . VAL A 1 97  ? -46.996 8.745   -6.511  1.00 42.70  ? 102 VAL C HG13 1 
ATOM   1493 H  HG21 . VAL A 1 97  ? -47.846 8.811   -9.303  1.00 51.68  ? 102 VAL C HG21 1 
ATOM   1494 H  HG22 . VAL A 1 97  ? -47.744 10.338  -8.883  1.00 51.68  ? 102 VAL C HG22 1 
ATOM   1495 H  HG23 . VAL A 1 97  ? -46.902 9.796   -10.114 1.00 51.68  ? 102 VAL C HG23 1 
ATOM   1496 N  N    . VAL A 1 98  ? -44.769 10.475  -5.366  1.00 34.14  ? 103 VAL C N    1 
ATOM   1497 C  CA   . VAL A 1 98  ? -43.857 10.244  -4.210  1.00 36.89  ? 103 VAL C CA   1 
ATOM   1498 C  C    . VAL A 1 98  ? -44.348 9.032   -3.407  1.00 36.94  ? 103 VAL C C    1 
ATOM   1499 O  O    . VAL A 1 98  ? -45.515 9.038   -3.014  1.00 37.64  ? 103 VAL C O    1 
ATOM   1500 C  CB   . VAL A 1 98  ? -43.755 11.517  -3.357  1.00 39.92  ? 103 VAL C CB   1 
ATOM   1501 C  CG1  . VAL A 1 98  ? -42.824 11.320  -2.171  1.00 42.01  ? 103 VAL C CG1  1 
ATOM   1502 C  CG2  . VAL A 1 98  ? -43.302 12.706  -4.195  1.00 37.74  ? 103 VAL C CG2  1 
ATOM   1503 H  H    . VAL A 1 98  ? -45.572 10.825  -5.153  1.00 41.01  ? 103 VAL C H    1 
ATOM   1504 H  HA   . VAL A 1 98  ? -42.966 10.042  -4.553  1.00 44.31  ? 103 VAL C HA   1 
ATOM   1505 H  HB   . VAL A 1 98  ? -44.656 11.712  -3.012  1.00 47.94  ? 103 VAL C HB   1 
ATOM   1506 H  HG11 . VAL A 1 98  ? -42.559 12.186  -1.819  1.00 50.46  ? 103 VAL C HG11 1 
ATOM   1507 H  HG12 . VAL A 1 98  ? -43.281 10.816  -1.478  1.00 50.46  ? 103 VAL C HG12 1 
ATOM   1508 H  HG13 . VAL A 1 98  ? -42.033 10.834  -2.459  1.00 50.46  ? 103 VAL C HG13 1 
ATOM   1509 H  HG21 . VAL A 1 98  ? -42.738 13.288  -3.659  1.00 45.33  ? 103 VAL C HG21 1 
ATOM   1510 H  HG22 . VAL A 1 98  ? -42.796 12.386  -4.962  1.00 45.33  ? 103 VAL C HG22 1 
ATOM   1511 H  HG23 . VAL A 1 98  ? -44.078 13.201  -4.505  1.00 45.33  ? 103 VAL C HG23 1 
ATOM   1512 N  N    . LEU A 1 99  ? -43.490 8.044   -3.179  1.00 31.92  ? 104 LEU C N    1 
ATOM   1513 C  CA   . LEU A 1 99  ? -43.846 6.791   -2.477  1.00 31.03  ? 104 LEU C CA   1 
ATOM   1514 C  C    . LEU A 1 99  ? -43.450 6.869   -0.992  1.00 32.61  ? 104 LEU C C    1 
ATOM   1515 O  O    . LEU A 1 99  ? -42.717 7.793   -0.629  1.00 32.21  ? 104 LEU C O    1 
ATOM   1516 C  CB   . LEU A 1 99  ? -43.140 5.649   -3.202  1.00 35.54  ? 104 LEU C CB   1 
ATOM   1517 C  CG   . LEU A 1 99  ? -43.445 5.471   -4.691  1.00 35.85  ? 104 LEU C CG   1 
ATOM   1518 C  CD1  . LEU A 1 99  ? -42.483 4.481   -5.303  1.00 37.78  ? 104 LEU C CD1  1 
ATOM   1519 C  CD2  . LEU A 1 99  ? -44.867 5.018   -4.913  1.00 42.33  ? 104 LEU C CD2  1 
ATOM   1520 H  H    . LEU A 1 99  ? -42.632 8.099   -3.451  1.00 38.35  ? 104 LEU C H    1 
ATOM   1521 H  HA   . LEU A 1 99  ? -44.825 6.666   -2.544  1.00 37.28  ? 104 LEU C HA   1 
ATOM   1522 H  HB2  . LEU A 1 99  ? -42.169 5.782   -3.101  1.00 42.69  ? 104 LEU C HB2  1 
ATOM   1523 H  HB3  . LEU A 1 99  ? -43.361 4.808   -2.744  1.00 42.69  ? 104 LEU C HB3  1 
ATOM   1524 H  HG   . LEU A 1 99  ? -43.319 6.342   -5.147  1.00 43.06  ? 104 LEU C HG   1 
ATOM   1525 H  HD11 . LEU A 1 99  ? -42.654 4.410   -6.258  1.00 45.38  ? 104 LEU C HD11 1 
ATOM   1526 H  HD12 . LEU A 1 99  ? -41.570 4.784   -5.159  1.00 45.38  ? 104 LEU C HD12 1 
ATOM   1527 H  HD13 . LEU A 1 99  ? -42.605 3.611   -4.887  1.00 45.38  ? 104 LEU C HD13 1 
ATOM   1528 H  HD21 . LEU A 1 99  ? -44.870 4.234   -5.488  1.00 50.84  ? 104 LEU C HD21 1 
ATOM   1529 H  HD22 . LEU A 1 99  ? -45.274 4.796   -4.059  1.00 50.84  ? 104 LEU C HD22 1 
ATOM   1530 H  HD23 . LEU A 1 99  ? -45.373 5.732   -5.337  1.00 50.84  ? 104 LEU C HD23 1 
ATOM   1531 N  N    . PRO A 1 100 ? -43.905 5.947   -0.120  1.00 25.80  ? 105 PRO C N    1 
ATOM   1532 C  CA   . PRO A 1 100 ? -43.621 6.037   1.309   1.00 34.85  ? 105 PRO C CA   1 
ATOM   1533 C  C    . PRO A 1 100 ? -42.145 5.956   1.697   1.00 34.01  ? 105 PRO C C    1 
ATOM   1534 O  O    . PRO A 1 100 ? -41.801 6.501   2.745   1.00 37.63  ? 105 PRO C O    1 
ATOM   1535 C  CB   . PRO A 1 100 ? -44.426 4.862   1.879   1.00 28.38  ? 105 PRO C CB   1 
ATOM   1536 C  CG   . PRO A 1 100 ? -45.475 4.593   0.843   1.00 35.43  ? 105 PRO C CG   1 
ATOM   1537 C  CD   . PRO A 1 100 ? -44.732 4.806   -0.448  1.00 34.05  ? 105 PRO C CD   1 
ATOM   1538 H  HA   . PRO A 1 100 ? -44.001 6.883   1.648   1.00 41.87  ? 105 PRO C HA   1 
ATOM   1539 H  HB2  . PRO A 1 100 ? -43.850 4.074   2.007   1.00 34.10  ? 105 PRO C HB2  1 
ATOM   1540 H  HB3  . PRO A 1 100 ? -44.837 5.104   2.741   1.00 34.10  ? 105 PRO C HB3  1 
ATOM   1541 H  HG2  . PRO A 1 100 ? -45.813 3.676   0.909   1.00 42.56  ? 105 PRO C HG2  1 
ATOM   1542 H  HG3  . PRO A 1 100 ? -46.223 5.220   0.926   1.00 42.56  ? 105 PRO C HG3  1 
ATOM   1543 H  HD2  . PRO A 1 100 ? -44.185 4.024   -0.677  1.00 40.90  ? 105 PRO C HD2  1 
ATOM   1544 H  HD3  . PRO A 1 100 ? -45.351 5.003   -1.183  1.00 40.90  ? 105 PRO C HD3  1 
ATOM   1545 N  N    . SER A 1 101 ? -41.309 5.315   0.885   1.00 32.14  ? 106 SER C N    1 
ATOM   1546 C  CA   . SER A 1 101 ? -39.854 5.178   1.127   1.00 28.10  ? 106 SER C CA   1 
ATOM   1547 C  C    . SER A 1 101 ? -39.116 6.472   0.786   1.00 33.02  ? 106 SER C C    1 
ATOM   1548 O  O    . SER A 1 101 ? -37.939 6.572   1.143   1.00 35.55  ? 106 SER C O    1 
ATOM   1549 C  CB   . SER A 1 101 ? -39.308 4.060   0.305   1.00 35.65  ? 106 SER C CB   1 
ATOM   1550 O  OG   . SER A 1 101 ? -39.394 4.357   -1.081  1.00 36.46  ? 106 SER C OG   1 
ATOM   1551 H  H    . SER A 1 101 ? -41.602 4.923   0.128   1.00 38.62  ? 106 SER C H    1 
ATOM   1552 H  HA   . SER A 1 101 ? -39.708 4.972   2.084   1.00 33.77  ? 106 SER C HA   1 
ATOM   1553 H  HB2  . SER A 1 101 ? -38.374 3.907   0.547   1.00 42.82  ? 106 SER C HB2  1 
ATOM   1554 H  HB3  . SER A 1 101 ? -39.807 3.246   0.496   1.00 42.82  ? 106 SER C HB3  1 
ATOM   1555 H  HG   . SER A 1 101 ? -38.642 4.626   -1.356  1.00 43.80  ? 106 SER C HG   1 
ATOM   1556 N  N    . GLY A 1 102 ? -39.748 7.380   0.048   1.00 31.68  ? 107 GLY C N    1 
ATOM   1557 C  CA   . GLY A 1 102 ? -39.089 8.611   -0.413  1.00 28.63  ? 107 GLY C CA   1 
ATOM   1558 C  C    . GLY A 1 102 ? -38.697 8.504   -1.869  1.00 30.09  ? 107 GLY C C    1 
ATOM   1559 O  O    . GLY A 1 102 ? -38.298 9.520   -2.442  1.00 32.00  ? 107 GLY C O    1 
ATOM   1560 H  H    . GLY A 1 102 ? -40.604 7.263   -0.217  1.00 38.06  ? 107 GLY C H    1 
ATOM   1561 H  HA2  . GLY A 1 102 ? -39.701 9.374   -0.290  1.00 34.40  ? 107 GLY C HA2  1 
ATOM   1562 H  HA3  . GLY A 1 102 ? -38.286 8.772   0.133   1.00 34.40  ? 107 GLY C HA3  1 
ATOM   1563 N  N    . LEU A 1 103 ? -38.781 7.314   -2.455  1.00 28.78  ? 108 LEU C N    1 
ATOM   1564 C  CA   . LEU A 1 103 ? -38.529 7.151   -3.904  1.00 32.09  ? 108 LEU C CA   1 
ATOM   1565 C  C    . LEU A 1 103 ? -39.599 7.949   -4.652  1.00 33.07  ? 108 LEU C C    1 
ATOM   1566 O  O    . LEU A 1 103 ? -40.758 7.902   -4.232  1.00 30.96  ? 108 LEU C O    1 
ATOM   1567 C  CB   . LEU A 1 103 ? -38.532 5.688   -4.328  1.00 26.82  ? 108 LEU C CB   1 
ATOM   1568 C  CG   . LEU A 1 103 ? -37.932 5.376   -5.700  1.00 37.47  ? 108 LEU C CG   1 
ATOM   1569 C  CD1  . LEU A 1 103 ? -36.442 5.147   -5.595  1.00 31.63  ? 108 LEU C CD1  1 
ATOM   1570 C  CD2  . LEU A 1 103 ? -38.617 4.165   -6.295  1.00 40.27  ? 108 LEU C CD2  1 
ATOM   1571 H  H    . LEU A 1 103 ? -39.006 6.571   -1.997  1.00 34.58  ? 108 LEU C H    1 
ATOM   1572 H  HA   . LEU A 1 103 ? -37.642 7.543   -4.108  1.00 38.55  ? 108 LEU C HA   1 
ATOM   1573 H  HB2  . LEU A 1 103 ? -38.037 5.174   -3.649  1.00 32.22  ? 108 LEU C HB2  1 
ATOM   1574 H  HB3  . LEU A 1 103 ? -39.464 5.370   -4.318  1.00 32.22  ? 108 LEU C HB3  1 
ATOM   1575 H  HG   . LEU A 1 103 ? -38.087 6.152   -6.296  1.00 45.01  ? 108 LEU C HG   1 
ATOM   1576 H  HD11 . LEU A 1 103 ? -36.092 4.875   -6.461  1.00 38.00  ? 108 LEU C HD11 1 
ATOM   1577 H  HD12 . LEU A 1 103 ? -36.006 5.967   -5.312  1.00 38.00  ? 108 LEU C HD12 1 
ATOM   1578 H  HD13 . LEU A 1 103 ? -36.267 4.448   -4.943  1.00 38.00  ? 108 LEU C HD13 1 
ATOM   1579 H  HD21 . LEU A 1 103 ? -38.223 3.962   -7.160  1.00 48.37  ? 108 LEU C HD21 1 
ATOM   1580 H  HD22 . LEU A 1 103 ? -38.503 3.404   -5.701  1.00 48.37  ? 108 LEU C HD22 1 
ATOM   1581 H  HD23 . LEU A 1 103 ? -39.565 4.351   -6.405  1.00 48.37  ? 108 LEU C HD23 1 
ATOM   1582 N  N    . GLN A 1 104 ? -39.206 8.690   -5.675  1.00 29.54  ? 109 GLN C N    1 
ATOM   1583 C  CA   . GLN A 1 104 ? -40.150 9.453   -6.521  1.00 33.49  ? 109 GLN C CA   1 
ATOM   1584 C  C    . GLN A 1 104 ? -40.015 8.892   -7.941  1.00 30.65  ? 109 GLN C C    1 
ATOM   1585 O  O    . GLN A 1 104 ? -38.935 8.385   -8.261  1.00 37.28  ? 109 GLN C O    1 
ATOM   1586 C  CB   . GLN A 1 104 ? -39.868 10.952  -6.486  1.00 28.18  ? 109 GLN C CB   1 
ATOM   1587 C  CG   . GLN A 1 104 ? -39.854 11.570  -5.094  1.00 35.50  ? 109 GLN C CG   1 
ATOM   1588 C  CD   . GLN A 1 104 ? -39.585 13.058  -5.115  1.00 39.84  ? 109 GLN C CD   1 
ATOM   1589 O  OE1  . GLN A 1 104 ? -39.305 13.651  -6.159  1.00 34.88  ? 109 GLN C OE1  1 
ATOM   1590 N  NE2  . GLN A 1 104 ? -39.666 13.678  -3.950  1.00 30.02  ? 109 GLN C NE2  1 
ATOM   1591 H  H    . GLN A 1 104 ? -38.335 8.761   -5.897  1.00 35.49  ? 109 GLN C H    1 
ATOM   1592 H  HA   . GLN A 1 104 ? -41.063 9.288   -6.191  1.00 40.23  ? 109 GLN C HA   1 
ATOM   1593 H  HB2  . GLN A 1 104 ? -39.000 11.110  -6.912  1.00 33.86  ? 109 GLN C HB2  1 
ATOM   1594 H  HB3  . GLN A 1 104 ? -40.549 11.405  -7.026  1.00 33.86  ? 109 GLN C HB3  1 
ATOM   1595 H  HG2  . GLN A 1 104 ? -40.719 11.409  -4.660  1.00 42.64  ? 109 GLN C HG2  1 
ATOM   1596 H  HG3  . GLN A 1 104 ? -39.163 11.136  -4.553  1.00 42.64  ? 109 GLN C HG3  1 
ATOM   1597 H  HE21 . GLN A 1 104 ? -40.311 13.460  -3.380  1.00 36.07  ? 109 GLN C HE21 1 
ATOM   1598 H  HE22 . GLN A 1 104 ? -39.080 14.310  -3.746  1.00 36.07  ? 109 GLN C HE22 1 
ATOM   1599 N  N    . TYR A 1 105 ? -41.072 8.956   -8.744  1.00 34.24  ? 110 TYR C N    1 
ATOM   1600 C  CA   . TYR A 1 105 ? -41.016 8.475   -10.147 1.00 32.73  ? 110 TYR C CA   1 
ATOM   1601 C  C    . TYR A 1 105 ? -41.931 9.292   -11.042 1.00 36.62  ? 110 TYR C C    1 
ATOM   1602 O  O    . TYR A 1 105 ? -42.873 9.911   -10.527 1.00 32.70  ? 110 TYR C O    1 
ATOM   1603 C  CB   . TYR A 1 105 ? -41.340 6.981   -10.277 1.00 28.28  ? 110 TYR C CB   1 
ATOM   1604 C  CG   . TYR A 1 105 ? -42.772 6.541   -10.034 1.00 32.97  ? 110 TYR C CG   1 
ATOM   1605 C  CD1  . TYR A 1 105 ? -43.697 6.524   -11.068 1.00 37.84  ? 110 TYR C CD1  1 
ATOM   1606 C  CD2  . TYR A 1 105 ? -43.182 6.097   -8.785  1.00 39.61  ? 110 TYR C CD2  1 
ATOM   1607 C  CE1  . TYR A 1 105 ? -44.998 6.107   -10.860 1.00 35.73  ? 110 TYR C CE1  1 
ATOM   1608 C  CE2  . TYR A 1 105 ? -44.480 5.677   -8.563  1.00 34.14  ? 110 TYR C CE2  1 
ATOM   1609 C  CZ   . TYR A 1 105 ? -45.389 5.683   -9.604  1.00 45.01  ? 110 TYR C CZ   1 
ATOM   1610 O  OH   . TYR A 1 105 ? -46.667 5.273   -9.386  1.00 36.69  ? 110 TYR C OH   1 
ATOM   1611 H  H    . TYR A 1 105 ? -41.855 9.309   -8.469  1.00 41.13  ? 110 TYR C H    1 
ATOM   1612 H  HA   . TYR A 1 105 ? -40.085 8.610   -10.469 1.00 39.32  ? 110 TYR C HA   1 
ATOM   1613 H  HB2  . TYR A 1 105 ? -41.081 6.694   -11.182 1.00 33.98  ? 110 TYR C HB2  1 
ATOM   1614 H  HB3  . TYR A 1 105 ? -40.759 6.491   -9.653  1.00 33.98  ? 110 TYR C HB3  1 
ATOM   1615 H  HD1  . TYR A 1 105 ? -43.436 6.811   -11.929 1.00 45.45  ? 110 TYR C HD1  1 
ATOM   1616 H  HD2  . TYR A 1 105 ? -42.566 6.092   -8.069  1.00 47.58  ? 110 TYR C HD2  1 
ATOM   1617 H  HE1  . TYR A 1 105 ? -45.616 6.111   -11.571 1.00 42.92  ? 110 TYR C HE1  1 
ATOM   1618 H  HE2  . TYR A 1 105 ? -44.745 5.391   -7.707  1.00 41.02  ? 110 TYR C HE2  1 
ATOM   1619 H  HH   . TYR A 1 105 ? -46.879 5.421   -8.568  1.00 44.07  ? 110 TYR C HH   1 
ATOM   1620 N  N    . LYS A 1 106 ? -41.631 9.312   -12.337 1.00 28.24  ? 111 LYS C N    1 
ATOM   1621 C  CA   . LYS A 1 106 ? -42.454 9.983   -13.366 1.00 31.87  ? 111 LYS C CA   1 
ATOM   1622 C  C    . LYS A 1 106 ? -42.562 9.017   -14.555 1.00 31.79  ? 111 LYS C C    1 
ATOM   1623 O  O    . LYS A 1 106 ? -41.522 8.536   -15.008 1.00 31.13  ? 111 LYS C O    1 
ATOM   1624 C  CB   . LYS A 1 106 ? -41.791 11.303  -13.746 1.00 29.20  ? 111 LYS C CB   1 
ATOM   1625 C  CG   . LYS A 1 106 ? -42.504 12.122  -14.788 1.00 48.62  ? 111 LYS C CG   1 
ATOM   1626 C  CD   . LYS A 1 106 ? -41.753 13.411  -15.066 1.00 46.07  ? 111 LYS C CD   1 
ATOM   1627 C  CE   . LYS A 1 106 ? -42.116 13.985  -16.383 1.00 57.85  ? 111 LYS C CE   1 
ATOM   1628 N  NZ   . LYS A 1 106 ? -40.923 14.110  -17.219 1.00 75.63  ? 111 LYS C NZ   1 
ATOM   1629 H  H    . LYS A 1 106 ? -40.885 8.913   -12.649 1.00 33.93  ? 111 LYS C H    1 
ATOM   1630 H  HA   . LYS A 1 106 ? -43.358 10.154  -13.002 1.00 38.28  ? 111 LYS C HA   1 
ATOM   1631 H  HB2  . LYS A 1 106 ? -41.703 11.848  -12.936 1.00 35.08  ? 111 LYS C HB2  1 
ATOM   1632 H  HB3  . LYS A 1 106 ? -40.886 11.112  -14.072 1.00 35.08  ? 111 LYS C HB3  1 
ATOM   1633 H  HG2  . LYS A 1 106 ? -42.575 11.601  -15.616 1.00 58.39  ? 111 LYS C HG2  1 
ATOM   1634 H  HG3  . LYS A 1 106 ? -43.409 12.331  -14.468 1.00 58.39  ? 111 LYS C HG3  1 
ATOM   1635 H  HD2  . LYS A 1 106 ? -41.957 14.060  -14.359 1.00 55.33  ? 111 LYS C HD2  1 
ATOM   1636 H  HD3  . LYS A 1 106 ? -40.788 13.229  -15.049 1.00 55.33  ? 111 LYS C HD3  1 
ATOM   1637 H  HE2  . LYS A 1 106 ? -42.758 13.404  -16.826 1.00 69.47  ? 111 LYS C HE2  1 
ATOM   1638 H  HE3  . LYS A 1 106 ? -42.521 14.862  -16.264 1.00 69.47  ? 111 LYS C HE3  1 
ATOM   1639 H  HZ1  . LYS A 1 106 ? -41.131 14.544  -17.986 1.00 90.80  ? 111 LYS C HZ1  1 
ATOM   1640 H  HZ2  . LYS A 1 106 ? -40.288 14.576  -16.772 1.00 90.80  ? 111 LYS C HZ2  1 
ATOM   1641 H  HZ3  . LYS A 1 106 ? -40.606 13.284  -17.416 1.00 90.80  ? 111 LYS C HZ3  1 
ATOM   1642 N  N    . VAL A 1 107 ? -43.774 8.745   -15.026 1.00 33.10  ? 112 VAL C N    1 
ATOM   1643 C  CA   . VAL A 1 107 ? -43.992 7.801   -16.159 1.00 32.43  ? 112 VAL C CA   1 
ATOM   1644 C  C    . VAL A 1 107 ? -43.775 8.557   -17.478 1.00 34.54  ? 112 VAL C C    1 
ATOM   1645 O  O    . VAL A 1 107 ? -44.461 9.560   -17.686 1.00 35.64  ? 112 VAL C O    1 
ATOM   1646 C  CB   . VAL A 1 107 ? -45.359 7.100   -16.145 1.00 35.36  ? 112 VAL C CB   1 
ATOM   1647 C  CG1  . VAL A 1 107 ? -45.476 6.110   -17.300 1.00 38.93  ? 112 VAL C CG1  1 
ATOM   1648 C  CG2  . VAL A 1 107 ? -45.600 6.394   -14.820 1.00 39.63  ? 112 VAL C CG2  1 
ATOM   1649 H  H    . VAL A 1 107 ? -44.513 9.130   -14.683 1.00 39.76  ? 112 VAL C H    1 
ATOM   1650 H  HA   . VAL A 1 107 ? -43.309 7.103   -16.101 1.00 38.95  ? 112 VAL C HA   1 
ATOM   1651 H  HB   . VAL A 1 107 ? -46.049 7.794   -16.259 1.00 42.48  ? 112 VAL C HB   1 
ATOM   1652 H  HG11 . VAL A 1 107 ? -46.094 5.400   -17.059 1.00 46.76  ? 112 VAL C HG11 1 
ATOM   1653 H  HG12 . VAL A 1 107 ? -45.803 6.568   -18.093 1.00 46.76  ? 112 VAL C HG12 1 
ATOM   1654 H  HG13 . VAL A 1 107 ? -44.601 5.726   -17.488 1.00 46.76  ? 112 VAL C HG13 1 
ATOM   1655 H  HG21 . VAL A 1 107 ? -46.413 5.865   -14.875 1.00 47.60  ? 112 VAL C HG21 1 
ATOM   1656 H  HG22 . VAL A 1 107 ? -44.848 5.810   -14.624 1.00 47.60  ? 112 VAL C HG22 1 
ATOM   1657 H  HG23 . VAL A 1 107 ? -45.689 7.053   -14.112 1.00 47.60  ? 112 VAL C HG23 1 
ATOM   1658 N  N    . ILE A 1 108 ? -42.822 8.114   -18.293 1.00 32.64  ? 113 ILE C N    1 
ATOM   1659 C  CA   . ILE A 1 108 ? -42.585 8.690   -19.645 1.00 30.60  ? 113 ILE C CA   1 
ATOM   1660 C  C    . ILE A 1 108 ? -43.495 7.922   -20.618 1.00 34.63  ? 113 ILE C C    1 
ATOM   1661 O  O    . ILE A 1 108 ? -44.156 8.588   -21.417 1.00 28.84  ? 113 ILE C O    1 
ATOM   1662 C  CB   . ILE A 1 108 ? -41.097 8.621   -20.020 1.00 26.97  ? 113 ILE C CB   1 
ATOM   1663 C  CG1  . ILE A 1 108 ? -40.187 9.032   -18.859 1.00 38.69  ? 113 ILE C CG1  1 
ATOM   1664 C  CG2  . ILE A 1 108 ? -40.813 9.445   -21.272 1.00 33.60  ? 113 ILE C CG2  1 
ATOM   1665 C  CD1  . ILE A 1 108 ? -40.620 10.292  -18.130 1.00 46.30  ? 113 ILE C CD1  1 
ATOM   1666 H  H    . ILE A 1 108 ? -42.280 7.432   -18.060 1.00 39.21  ? 113 ILE C H    1 
ATOM   1667 H  HA   . ILE A 1 108 ? -42.856 9.627   -19.641 1.00 36.77  ? 113 ILE C HA   1 
ATOM   1668 H  HB   . ILE A 1 108 ? -40.895 7.686   -20.230 1.00 32.40  ? 113 ILE C HB   1 
ATOM   1669 H  HG12 . ILE A 1 108 ? -40.146 8.294   -18.215 1.00 46.47  ? 113 ILE C HG12 1 
ATOM   1670 H  HG13 . ILE A 1 108 ? -39.283 9.171   -19.207 1.00 46.47  ? 113 ILE C HG13 1 
ATOM   1671 H  HG21 . ILE A 1 108 ? -39.853 9.553   -21.379 1.00 40.37  ? 113 ILE C HG21 1 
ATOM   1672 H  HG22 . ILE A 1 108 ? -41.176 8.993   -22.051 1.00 40.37  ? 113 ILE C HG22 1 
ATOM   1673 H  HG23 . ILE A 1 108 ? -41.227 10.320  -21.184 1.00 40.37  ? 113 ILE C HG23 1 
ATOM   1674 H  HD11 . ILE A 1 108 ? -39.991 10.486  -17.409 1.00 55.61  ? 113 ILE C HD11 1 
ATOM   1675 H  HD12 . ILE A 1 108 ? -40.639 11.043  -18.753 1.00 55.61  ? 113 ILE C HD12 1 
ATOM   1676 H  HD13 . ILE A 1 108 ? -41.511 10.162  -17.753 1.00 55.61  ? 113 ILE C HD13 1 
ATOM   1677 N  N    . ASN A 1 109 ? -43.535 6.590   -20.535 1.00 28.82  ? 114 ASN C N    1 
ATOM   1678 C  CA   . ASN A 1 109 ? -44.427 5.741   -21.367 1.00 24.11  ? 114 ASN C CA   1 
ATOM   1679 C  C    . ASN A 1 109 ? -44.788 4.472   -20.599 1.00 33.55  ? 114 ASN C C    1 
ATOM   1680 O  O    . ASN A 1 109 ? -43.879 3.818   -20.097 1.00 32.57  ? 114 ASN C O    1 
ATOM   1681 C  CB   . ASN A 1 109 ? -43.828 5.374   -22.715 1.00 30.78  ? 114 ASN C CB   1 
ATOM   1682 C  CG   . ASN A 1 109 ? -44.744 4.484   -23.518 1.00 32.88  ? 114 ASN C CG   1 
ATOM   1683 O  OD1  . ASN A 1 109 ? -45.716 4.963   -24.106 1.00 29.24  ? 114 ASN C OD1  1 
ATOM   1684 N  ND2  . ASN A 1 109 ? -44.460 3.193   -23.543 1.00 31.70  ? 114 ASN C ND2  1 
ATOM   1685 H  H    . ASN A 1 109 ? -43.010 6.142   -19.955 1.00 34.63  ? 114 ASN C H    1 
ATOM   1686 H  HA   . ASN A 1 109 ? -45.256 6.239   -21.539 1.00 28.98  ? 114 ASN C HA   1 
ATOM   1687 H  HB2  . ASN A 1 109 ? -43.649 6.191   -23.220 1.00 36.97  ? 114 ASN C HB2  1 
ATOM   1688 H  HB3  . ASN A 1 109 ? -42.978 4.913   -22.572 1.00 36.97  ? 114 ASN C HB3  1 
ATOM   1689 H  HD21 . ASN A 1 109 ? -44.892 2.654   -24.097 1.00 38.09  ? 114 ASN C HD21 1 
ATOM   1690 H  HD22 . ASN A 1 109 ? -43.841 2.869   -22.995 1.00 38.09  ? 114 ASN C HD22 1 
ATOM   1691 N  N    . SER A 1 110 ? -46.074 4.142   -20.539 1.00 32.23  ? 115 SER C N    1 
ATOM   1692 C  CA   . SER A 1 110 ? -46.559 2.950   -19.805 1.00 37.40  ? 115 SER C CA   1 
ATOM   1693 C  C    . SER A 1 110 ? -46.630 1.742   -20.736 1.00 40.58  ? 115 SER C C    1 
ATOM   1694 O  O    . SER A 1 110 ? -47.104 1.907   -21.865 1.00 40.50  ? 115 SER C O    1 
ATOM   1695 C  CB   . SER A 1 110 ? -47.887 3.204   -19.166 1.00 39.71  ? 115 SER C CB   1 
ATOM   1696 O  OG   . SER A 1 110 ? -48.244 2.120   -18.323 1.00 55.48  ? 115 SER C OG   1 
ATOM   1697 H  H    . SER A 1 110 ? -46.708 4.634   -20.950 1.00 38.72  ? 115 SER C H    1 
ATOM   1698 H  HA   . SER A 1 110 ? -45.911 2.743   -19.086 1.00 44.92  ? 115 SER C HA   1 
ATOM   1699 H  HB2  . SER A 1 110 ? -47.840 4.027   -18.643 1.00 47.69  ? 115 SER C HB2  1 
ATOM   1700 H  HB3  . SER A 1 110 ? -48.563 3.316   -19.859 1.00 47.69  ? 115 SER C HB3  1 
ATOM   1701 H  HG   . SER A 1 110 ? -48.684 2.416   -17.666 1.00 66.62  ? 115 SER C HG   1 
ATOM   1702 N  N    . GLY A 1 111 ? -46.199 0.587   -20.257 1.00 29.61  ? 116 GLY C N    1 
ATOM   1703 C  CA   . GLY A 1 111 ? -46.242 -0.671  -21.011 1.00 35.61  ? 116 GLY C CA   1 
ATOM   1704 C  C    . GLY A 1 111 ? -47.492 -1.458  -20.680 1.00 37.49  ? 116 GLY C C    1 
ATOM   1705 O  O    . GLY A 1 111 ? -48.245 -0.995  -19.809 1.00 34.10  ? 116 GLY C O    1 
ATOM   1706 H  H    . GLY A 1 111 ? -45.911 0.520   -19.414 1.00 35.58  ? 116 GLY C H    1 
ATOM   1707 H  HA2  . GLY A 1 111 ? -46.214 -0.481  -21.977 1.00 42.78  ? 116 GLY C HA2  1 
ATOM   1708 H  HA3  . GLY A 1 111 ? -45.446 -1.209  -20.784 1.00 42.78  ? 116 GLY C HA3  1 
ATOM   1709 N  N    . ASN A 1 112 ? -47.682 -2.613  -21.317 1.00 35.48  ? 117 ASN C N    1 
ATOM   1710 C  CA   . ASN A 1 112 ? -48.905 -3.445  -21.149 1.00 33.35  ? 117 ASN C CA   1 
ATOM   1711 C  C    . ASN A 1 112 ? -48.540 -4.837  -20.623 1.00 40.38  ? 117 ASN C C    1 
ATOM   1712 O  O    . ASN A 1 112 ? -49.444 -5.668  -20.505 1.00 44.43  ? 117 ASN C O    1 
ATOM   1713 C  CB   . ASN A 1 112 ? -49.663 -3.506  -22.468 1.00 35.43  ? 117 ASN C CB   1 
ATOM   1714 C  CG   . ASN A 1 112 ? -48.823 -4.029  -23.607 1.00 40.13  ? 117 ASN C CG   1 
ATOM   1715 O  OD1  . ASN A 1 112 ? -48.304 -5.146  -23.546 1.00 40.46  ? 117 ASN C OD1  1 
ATOM   1716 N  ND2  . ASN A 1 112 ? -48.678 -3.233  -24.652 1.00 46.73  ? 117 ASN C ND2  1 
ATOM   1717 H  H    . ASN A 1 112 ? -47.058 -2.934  -21.883 1.00 42.62  ? 117 ASN C H    1 
ATOM   1718 H  HA   . ASN A 1 112 ? -49.494 -3.015  -20.493 1.00 40.06  ? 117 ASN C HA   1 
ATOM   1719 H  HB2  . ASN A 1 112 ? -50.447 -4.079  -22.361 1.00 42.56  ? 117 ASN C HB2  1 
ATOM   1720 H  HB3  . ASN A 1 112 ? -49.976 -2.608  -22.693 1.00 42.56  ? 117 ASN C HB3  1 
ATOM   1721 H  HD21 . ASN A 1 112 ? -48.492 -3.578  -25.448 1.00 56.12  ? 117 ASN C HD21 1 
ATOM   1722 H  HD22 . ASN A 1 112 ? -48.763 -2.356  -24.552 1.00 56.12  ? 117 ASN C HD22 1 
ATOM   1723 N  N    . GLY A 1 113 ? -47.277 -5.075  -20.308 1.00 37.62  ? 118 GLY C N    1 
ATOM   1724 C  CA   . GLY A 1 113 ? -46.798 -6.387  -19.857 1.00 37.80  ? 118 GLY C CA   1 
ATOM   1725 C  C    . GLY A 1 113 ? -46.965 -6.619  -18.371 1.00 41.48  ? 118 GLY C C    1 
ATOM   1726 O  O    . GLY A 1 113 ? -47.693 -5.849  -17.726 1.00 41.16  ? 118 GLY C O    1 
ATOM   1727 H  H    . GLY A 1 113 ? -46.649 -4.424  -20.350 1.00 45.19  ? 118 GLY C H    1 
ATOM   1728 H  HA2  . GLY A 1 113 ? -47.280 -7.090  -20.350 1.00 45.40  ? 118 GLY C HA2  1 
ATOM   1729 H  HA3  . GLY A 1 113 ? -45.842 -6.467  -20.086 1.00 45.40  ? 118 GLY C HA3  1 
ATOM   1730 N  N    . VAL A 1 114 ? -46.271 -7.620  -17.844 1.00 42.36  ? 119 VAL C N    1 
ATOM   1731 C  CA   . VAL A 1 114 ? -46.390 -8.022  -16.416 1.00 47.92  ? 119 VAL C CA   1 
ATOM   1732 C  C    . VAL A 1 114 ? -45.396 -7.251  -15.539 1.00 47.16  ? 119 VAL C C    1 
ATOM   1733 O  O    . VAL A 1 114 ? -44.308 -6.918  -16.034 1.00 36.62  ? 119 VAL C O    1 
ATOM   1734 C  CB   . VAL A 1 114 ? -46.191 -9.542  -16.258 1.00 46.07  ? 119 VAL C CB   1 
ATOM   1735 C  CG1  . VAL A 1 114 ? -47.205 -10.326 -17.074 1.00 59.16  ? 119 VAL C CG1  1 
ATOM   1736 C  CG2  . VAL A 1 114 ? -44.774 -9.995  -16.571 1.00 45.21  ? 119 VAL C CG2  1 
ATOM   1737 H  H    . VAL A 1 114 ? -45.677 -8.086  -18.336 1.00 50.87  ? 119 VAL C H    1 
ATOM   1738 H  HA   . VAL A 1 114 ? -47.291 -7.806  -16.115 1.00 57.55  ? 119 VAL C HA   1 
ATOM   1739 H  HB   . VAL A 1 114 ? -46.358 -9.750  -15.310 1.00 55.33  ? 119 VAL C HB   1 
ATOM   1740 H  HG11 . VAL A 1 114 ? -47.433 -11.147 -16.607 1.00 71.04  ? 119 VAL C HG11 1 
ATOM   1741 H  HG12 . VAL A 1 114 ? -48.006 -9.789  -17.194 1.00 71.04  ? 119 VAL C HG12 1 
ATOM   1742 H  HG13 . VAL A 1 114 ? -46.827 -10.542 -17.941 1.00 71.04  ? 119 VAL C HG13 1 
ATOM   1743 H  HG21 . VAL A 1 114 ? -44.802 -10.843 -17.043 1.00 54.30  ? 119 VAL C HG21 1 
ATOM   1744 H  HG22 . VAL A 1 114 ? -44.328 -9.334  -17.124 1.00 54.30  ? 119 VAL C HG22 1 
ATOM   1745 H  HG23 . VAL A 1 114 ? -44.285 -10.105 -15.741 1.00 54.30  ? 119 VAL C HG23 1 
ATOM   1746 N  N    . LYS A 1 115 ? -45.784 -6.991  -14.294 1.00 38.46  ? 120 LYS C N    1 
ATOM   1747 C  CA   . LYS A 1 115 ? -44.921 -6.313  -13.305 1.00 39.10  ? 120 LYS C CA   1 
ATOM   1748 C  C    . LYS A 1 115 ? -44.034 -7.364  -12.636 1.00 48.88  ? 120 LYS C C    1 
ATOM   1749 O  O    . LYS A 1 115 ? -44.593 -8.343  -12.123 1.00 45.34  ? 120 LYS C O    1 
ATOM   1750 C  CB   . LYS A 1 115 ? -45.814 -5.619  -12.282 1.00 40.24  ? 120 LYS C CB   1 
ATOM   1751 C  CG   . LYS A 1 115 ? -46.632 -4.491  -12.849 1.00 35.12  ? 120 LYS C CG   1 
ATOM   1752 C  CD   . LYS A 1 115 ? -47.354 -3.705  -11.773 1.00 41.69  ? 120 LYS C CD   1 
ATOM   1753 C  CE   . LYS A 1 115 ? -48.187 -2.653  -12.389 1.00 46.79  ? 120 LYS C CE   1 
ATOM   1754 N  NZ   . LYS A 1 115 ? -49.049 -2.051  -11.376 1.00 65.96  ? 120 LYS C NZ   1 
ATOM   1755 H  H    . LYS A 1 115 ? -46.602 -7.226  -14.002 1.00 46.19  ? 120 LYS C H    1 
ATOM   1756 H  HA   . LYS A 1 115 ? -44.377 -5.643  -13.771 1.00 46.96  ? 120 LYS C HA   1 
ATOM   1757 H  HB2  . LYS A 1 115 ? -46.423 -6.280  -11.890 1.00 48.33  ? 120 LYS C HB2  1 
ATOM   1758 H  HB3  . LYS A 1 115 ? -45.251 -5.264  -11.562 1.00 48.33  ? 120 LYS C HB3  1 
ATOM   1759 H  HG2  . LYS A 1 115 ? -46.038 -3.889  -13.346 1.00 42.19  ? 120 LYS C HG2  1 
ATOM   1760 H  HG3  . LYS A 1 115 ? -47.290 -4.859  -13.477 1.00 42.19  ? 120 LYS C HG3  1 
ATOM   1761 H  HD2  . LYS A 1 115 ? -47.924 -4.309  -11.251 1.00 50.08  ? 120 LYS C HD2  1 
ATOM   1762 H  HD3  . LYS A 1 115 ? -46.695 -3.290  -11.173 1.00 50.08  ? 120 LYS C HD3  1 
ATOM   1763 H  HE2  . LYS A 1 115 ? -47.617 -1.969  -12.782 1.00 56.19  ? 120 LYS C HE2  1 
ATOM   1764 H  HE3  . LYS A 1 115 ? -48.735 -3.040  -13.095 1.00 56.19  ? 120 LYS C HE3  1 
ATOM   1765 H  HZ1  . LYS A 1 115 ? -49.464 -1.325  -11.723 1.00 79.20  ? 120 LYS C HZ1  1 
ATOM   1766 H  HZ2  . LYS A 1 115 ? -49.666 -2.654  -11.103 1.00 79.20  ? 120 LYS C HZ2  1 
ATOM   1767 H  HZ3  . LYS A 1 115 ? -48.540 -1.798  -10.670 1.00 79.20  ? 120 LYS C HZ3  1 
ATOM   1768 N  N    . PRO A 1 116 ? -42.695 -7.225  -12.618 1.00 45.38  ? 121 PRO C N    1 
ATOM   1769 C  CA   . PRO A 1 116 ? -41.848 -8.266  -12.062 1.00 41.70  ? 121 PRO C CA   1 
ATOM   1770 C  C    . PRO A 1 116 ? -41.928 -8.445  -10.559 1.00 47.84  ? 121 PRO C C    1 
ATOM   1771 O  O    . PRO A 1 116 ? -42.298 -7.495  -9.863  1.00 41.48  ? 121 PRO C O    1 
ATOM   1772 C  CB   . PRO A 1 116 ? -40.458 -7.794  -12.493 1.00 44.87  ? 121 PRO C CB   1 
ATOM   1773 C  CG   . PRO A 1 116 ? -40.573 -6.307  -12.547 1.00 42.59  ? 121 PRO C CG   1 
ATOM   1774 C  CD   . PRO A 1 116 ? -41.945 -6.109  -13.146 1.00 42.94  ? 121 PRO C CD   1 
ATOM   1775 H  HA   . PRO A 1 116 ? -42.055 -9.123  -12.512 1.00 50.08  ? 121 PRO C HA   1 
ATOM   1776 H  HB2  . PRO A 1 116 ? -39.774 -8.070  -11.838 1.00 53.89  ? 121 PRO C HB2  1 
ATOM   1777 H  HB3  . PRO A 1 116 ? -40.222 -8.159  -13.377 1.00 53.89  ? 121 PRO C HB3  1 
ATOM   1778 H  HG2  . PRO A 1 116 ? -40.515 -5.921  -11.650 1.00 51.16  ? 121 PRO C HG2  1 
ATOM   1779 H  HG3  . PRO A 1 116 ? -39.878 -5.915  -13.116 1.00 51.16  ? 121 PRO C HG3  1 
ATOM   1780 H  HD2  . PRO A 1 116 ? -42.338 -5.259  -12.864 1.00 51.57  ? 121 PRO C HD2  1 
ATOM   1781 H  HD3  . PRO A 1 116 ? -41.911 -6.140  -14.128 1.00 51.57  ? 121 PRO C HD3  1 
ATOM   1782 N  N    . GLY A 1 117 ? -41.582 -9.634  -10.075 1.00 50.14  ? 122 GLY C N    1 
ATOM   1783 C  CA   . GLY A 1 117 ? -41.540 -9.936  -8.636  1.00 51.23  ? 122 GLY C CA   1 
ATOM   1784 C  C    . GLY A 1 117 ? -40.121 -9.894  -8.118  1.00 36.45  ? 122 GLY C C    1 
ATOM   1785 O  O    . GLY A 1 117 ? -39.224 -9.607  -8.919  1.00 50.19  ? 122 GLY C O    1 
ATOM   1786 H  H    . GLY A 1 117 ? -41.345 -10.311 -10.624 1.00 60.21  ? 122 GLY C H    1 
ATOM   1787 H  HA2  . GLY A 1 117 ? -42.091 -9.286  -8.143  1.00 61.52  ? 122 GLY C HA2  1 
ATOM   1788 H  HA3  . GLY A 1 117 ? -41.919 -10.832 -8.482  1.00 61.52  ? 122 GLY C HA3  1 
ATOM   1789 N  N    . LYS A 1 118 ? -39.906 -10.229 -6.849  1.00 52.83  ? 123 LYS C N    1 
ATOM   1790 C  CA   . LYS A 1 118 ? -38.575 -10.107 -6.196  1.00 49.16  ? 123 LYS C CA   1 
ATOM   1791 C  C    . LYS A 1 118 ? -37.599 -11.194 -6.656  1.00 53.68  ? 123 LYS C C    1 
ATOM   1792 O  O    . LYS A 1 118 ? -36.403 -10.885 -6.796  1.00 57.02  ? 123 LYS C O    1 
ATOM   1793 C  CB   . LYS A 1 118 ? -38.850 -10.166 -4.698  1.00 57.72  ? 123 LYS C CB   1 
ATOM   1794 C  CG   . LYS A 1 118 ? -39.802 -9.092  -4.223  1.00 65.07  ? 123 LYS C CG   1 
ATOM   1795 C  CD   . LYS A 1 118 ? -39.502 -8.605  -2.818  1.00 65.35  ? 123 LYS C CD   1 
ATOM   1796 C  CE   . LYS A 1 118 ? -40.705 -8.674  -1.939  1.00 60.59  ? 123 LYS C CE   1 
ATOM   1797 N  NZ   . LYS A 1 118 ? -41.618 -7.549  -2.151  1.00 54.55  ? 123 LYS C NZ   1 
ATOM   1798 H  H    . LYS A 1 118 ? -40.570 -10.563 -6.338  1.00 63.44  ? 123 LYS C H    1 
ATOM   1799 H  HA   . LYS A 1 118 ? -38.195 -9.219  -6.419  1.00 59.03  ? 123 LYS C HA   1 
ATOM   1800 H  HB2  . LYS A 1 118 ? -39.230 -11.042 -4.477  1.00 69.30  ? 123 LYS C HB2  1 
ATOM   1801 H  HB3  . LYS A 1 118 ? -38.003 -10.072 -4.215  1.00 69.30  ? 123 LYS C HB3  1 
ATOM   1802 H  HG2  . LYS A 1 118 ? -39.748 -8.334  -4.843  1.00 78.13  ? 123 LYS C HG2  1 
ATOM   1803 H  HG3  . LYS A 1 118 ? -40.717 -9.444  -4.254  1.00 78.13  ? 123 LYS C HG3  1 
ATOM   1804 H  HD2  . LYS A 1 118 ? -38.786 -9.150  -2.429  1.00 78.46  ? 123 LYS C HD2  1 
ATOM   1805 H  HD3  . LYS A 1 118 ? -39.189 -7.680  -2.873  1.00 78.46  ? 123 LYS C HD3  1 
ATOM   1806 H  HE2  . LYS A 1 118 ? -41.177 -9.507  -2.112  1.00 72.76  ? 123 LYS C HE2  1 
ATOM   1807 H  HE3  . LYS A 1 118 ? -40.417 -8.677  -1.008  1.00 72.76  ? 123 LYS C HE3  1 
ATOM   1808 H  HZ1  . LYS A 1 118 ? -41.806 -7.149  -1.361  1.00 65.50  ? 123 LYS C HZ1  1 
ATOM   1809 H  HZ2  . LYS A 1 118 ? -41.229 -6.944  -2.700  1.00 65.50  ? 123 LYS C HZ2  1 
ATOM   1810 H  HZ3  . LYS A 1 118 ? -42.385 -7.843  -2.531  1.00 65.50  ? 123 LYS C HZ3  1 
ATOM   1811 N  N    . SER A 1 119 ? -38.085 -12.405 -6.892  1.00 49.86  ? 124 SER C N    1 
ATOM   1812 C  CA   . SER A 1 119 ? -37.232 -13.537 -7.327  1.00 55.05  ? 124 SER C CA   1 
ATOM   1813 C  C    . SER A 1 119 ? -36.983 -13.462 -8.831  1.00 55.74  ? 124 SER C C    1 
ATOM   1814 O  O    . SER A 1 119 ? -36.094 -14.191 -9.313  1.00 59.93  ? 124 SER C O    1 
ATOM   1815 C  CB   . SER A 1 119 ? -37.892 -14.837 -6.972  1.00 56.66  ? 124 SER C CB   1 
ATOM   1816 O  OG   . SER A 1 119 ? -39.291 -14.782 -7.212  1.00 62.44  ? 124 SER C OG   1 
ATOM   1817 H  H    . SER A 1 119 ? -38.964 -12.587 -6.807  1.00 59.88  ? 124 SER C H    1 
ATOM   1818 H  HA   . SER A 1 119 ? -36.362 -13.478 -6.858  1.00 66.10  ? 124 SER C HA   1 
ATOM   1819 H  HB2  . SER A 1 119 ? -37.501 -15.555 -7.505  1.00 68.03  ? 124 SER C HB2  1 
ATOM   1820 H  HB3  . SER A 1 119 ? -37.731 -15.034 -6.031  1.00 68.03  ? 124 SER C HB3  1 
ATOM   1821 H  HG   . SER A 1 119 ? -39.426 -14.539 -8.011  1.00 74.97  ? 124 SER C HG   1 
ATOM   1822 N  N    . ASP A 1 120 ? -37.706 -12.599 -9.535  1.00 49.39  ? 125 ASP C N    1 
ATOM   1823 C  CA   . ASP A 1 120 ? -37.652 -12.573 -11.019 1.00 49.46  ? 125 ASP C CA   1 
ATOM   1824 C  C    . ASP A 1 120 ? -36.355 -11.991 -11.572 1.00 48.18  ? 125 ASP C C    1 
ATOM   1825 O  O    . ASP A 1 120 ? -35.650 -11.300 -10.832 1.00 50.11  ? 125 ASP C O    1 
ATOM   1826 C  CB   . ASP A 1 120 ? -38.848 -11.830 -11.591 1.00 44.47  ? 125 ASP C CB   1 
ATOM   1827 C  CG   . ASP A 1 120 ? -40.215 -12.451 -11.353 1.00 47.55  ? 125 ASP C CG   1 
ATOM   1828 O  OD1  . ASP A 1 120 ? -40.272 -13.622 -10.950 1.00 55.43  ? 125 ASP C OD1  1 
ATOM   1829 O  OD2  . ASP A 1 120 ? -41.215 -11.748 -11.572 1.00 48.48  ? 125 ASP C OD2  1 
ATOM   1830 H  H    . ASP A 1 120 ? -38.255 -12.006 -9.137  1.00 59.32  ? 125 ASP C H    1 
ATOM   1831 H  HA   . ASP A 1 120 ? -37.720 -13.501 -11.339 1.00 59.39  ? 125 ASP C HA   1 
ATOM   1832 H  HB2  . ASP A 1 120 ? -38.861 -10.921 -11.225 1.00 53.41  ? 125 ASP C HB2  1 
ATOM   1833 H  HB3  . ASP A 1 120 ? -38.720 -11.756 -12.559 1.00 53.41  ? 125 ASP C HB3  1 
ATOM   1834 N  N    . THR A 1 121 ? -36.038 -12.313 -12.821 1.00 50.64  ? 126 THR C N    1 
ATOM   1835 C  CA   . THR A 1 121 ? -34.890 -11.764 -13.551 1.00 46.55  ? 126 THR C CA   1 
ATOM   1836 C  C    . THR A 1 121 ? -35.480 -10.820 -14.573 1.00 48.74  ? 126 THR C C    1 
ATOM   1837 O  O    . THR A 1 121 ? -36.504 -11.200 -15.162 1.00 49.70  ? 126 THR C O    1 
ATOM   1838 C  CB   . THR A 1 121 ? -34.109 -12.912 -14.183 1.00 56.63  ? 126 THR C CB   1 
ATOM   1839 O  OG1  . THR A 1 121 ? -33.340 -13.479 -13.129 1.00 55.12  ? 126 THR C OG1  1 
ATOM   1840 C  CG2  . THR A 1 121 ? -33.205 -12.453 -15.310 1.00 53.84  ? 126 THR C CG2  1 
ATOM   1841 H  H    . THR A 1 121 ? -36.513 -12.898 -13.317 1.00 60.81  ? 126 THR C H    1 
ATOM   1842 H  HA   . THR A 1 121 ? -34.313 -11.268 -12.930 1.00 55.90  ? 126 THR C HA   1 
ATOM   1843 H  HB   . THR A 1 121 ? -34.740 -13.587 -14.526 1.00 67.99  ? 126 THR C HB   1 
ATOM   1844 H  HG1  . THR A 1 121 ? -33.019 -14.236 -13.389 1.00 66.19  ? 126 THR C HG1  1 
ATOM   1845 H  HG21 . THR A 1 121 ? -32.834 -13.229 -15.762 1.00 64.65  ? 126 THR C HG21 1 
ATOM   1846 H  HG22 . THR A 1 121 ? -33.721 -11.926 -15.943 1.00 64.65  ? 126 THR C HG22 1 
ATOM   1847 H  HG23 . THR A 1 121 ? -32.484 -11.912 -14.949 1.00 64.65  ? 126 THR C HG23 1 
ATOM   1848 N  N    . VAL A 1 122 ? -34.905 -9.632  -14.760 1.00 45.52  ? 127 VAL C N    1 
ATOM   1849 C  CA   . VAL A 1 122 ? -35.451 -8.592  -15.677 1.00 41.05  ? 127 VAL C CA   1 
ATOM   1850 C  C    . VAL A 1 122 ? -34.341 -8.128  -16.620 1.00 39.93  ? 127 VAL C C    1 
ATOM   1851 O  O    . VAL A 1 122 ? -33.184 -8.160  -16.192 1.00 48.44  ? 127 VAL C O    1 
ATOM   1852 C  CB   . VAL A 1 122 ? -36.060 -7.403  -14.906 1.00 42.43  ? 127 VAL C CB   1 
ATOM   1853 C  CG1  . VAL A 1 122 ? -37.323 -7.799  -14.157 1.00 41.75  ? 127 VAL C CG1  1 
ATOM   1854 C  CG2  . VAL A 1 122 ? -35.067 -6.727  -13.969 1.00 39.29  ? 127 VAL C CG2  1 
ATOM   1855 H  H    . VAL A 1 122 ? -34.140 -9.407  -14.339 1.00 54.67  ? 127 VAL C H    1 
ATOM   1856 H  HA   . VAL A 1 122 ? -36.154 -8.993  -16.216 1.00 49.31  ? 127 VAL C HA   1 
ATOM   1857 H  HB   . VAL A 1 122 ? -36.318 -6.734  -15.579 1.00 50.96  ? 127 VAL C HB   1 
ATOM   1858 H  HG11 . VAL A 1 122 ? -37.896 -7.021  -14.050 1.00 50.14  ? 127 VAL C HG11 1 
ATOM   1859 H  HG12 . VAL A 1 122 ? -37.798 -8.482  -14.662 1.00 50.14  ? 127 VAL C HG12 1 
ATOM   1860 H  HG13 . VAL A 1 122 ? -37.086 -8.149  -13.282 1.00 50.14  ? 127 VAL C HG13 1 
ATOM   1861 H  HG21 . VAL A 1 122 ? -35.539 -6.088  -13.409 1.00 47.19  ? 127 VAL C HG21 1 
ATOM   1862 H  HG22 . VAL A 1 122 ? -34.640 -7.394  -13.407 1.00 47.19  ? 127 VAL C HG22 1 
ATOM   1863 H  HG23 . VAL A 1 122 ? -34.392 -6.262  -14.490 1.00 47.19  ? 127 VAL C HG23 1 
ATOM   1864 N  N    . THR A 1 123 ? -34.680 -7.771  -17.854 1.00 35.28  ? 128 THR C N    1 
ATOM   1865 C  CA   . THR A 1 123 ? -33.730 -7.231  -18.841 1.00 31.93  ? 128 THR C CA   1 
ATOM   1866 C  C    . THR A 1 123 ? -34.123 -5.793  -19.038 1.00 39.31  ? 128 THR C C    1 
ATOM   1867 O  O    . THR A 1 123 ? -35.325 -5.554  -19.230 1.00 37.27  ? 128 THR C O    1 
ATOM   1868 C  CB   . THR A 1 123 ? -33.736 -8.038  -20.133 1.00 41.00  ? 128 THR C CB   1 
ATOM   1869 O  OG1  . THR A 1 123 ? -33.467 -9.375  -19.731 1.00 49.44  ? 128 THR C OG1  1 
ATOM   1870 C  CG2  . THR A 1 123 ? -32.679 -7.551  -21.104 1.00 46.53  ? 128 THR C CG2  1 
ATOM   1871 H  H    . THR A 1 123 ? -35.520 -7.827  -18.178 1.00 42.38  ? 128 THR C H    1 
ATOM   1872 H  HA   . THR A 1 123 ? -32.830 -7.261  -18.463 1.00 38.36  ? 128 THR C HA   1 
ATOM   1873 H  HB   . THR A 1 123 ? -34.627 -7.990  -20.555 1.00 49.24  ? 128 THR C HB   1 
ATOM   1874 H  HG1  . THR A 1 123 ? -32.906 -9.365  -19.072 1.00 59.37  ? 128 THR C HG1  1 
ATOM   1875 H  HG21 . THR A 1 123 ? -32.503 -8.240  -21.765 1.00 55.88  ? 128 THR C HG21 1 
ATOM   1876 H  HG22 . THR A 1 123 ? -32.992 -6.745  -21.550 1.00 55.88  ? 128 THR C HG22 1 
ATOM   1877 H  HG23 . THR A 1 123 ? -31.860 -7.352  -20.618 1.00 55.88  ? 128 THR C HG23 1 
ATOM   1878 N  N    . VAL A 1 124 ? -33.166 -4.872  -18.998 1.00 39.74  ? 129 VAL C N    1 
ATOM   1879 C  CA   . VAL A 1 124 ? -33.471 -3.415  -19.014 1.00 36.36  ? 129 VAL C CA   1 
ATOM   1880 C  C    . VAL A 1 124 ? -32.420 -2.600  -19.761 1.00 36.10  ? 129 VAL C C    1 
ATOM   1881 O  O    . VAL A 1 124 ? -31.323 -3.115  -19.974 1.00 37.54  ? 129 VAL C O    1 
ATOM   1882 C  CB   . VAL A 1 124 ? -33.559 -2.884  -17.567 1.00 32.67  ? 129 VAL C CB   1 
ATOM   1883 C  CG1  . VAL A 1 124 ? -34.561 -3.653  -16.716 1.00 41.86  ? 129 VAL C CG1  1 
ATOM   1884 C  CG2  . VAL A 1 124 ? -32.199 -2.837  -16.883 1.00 39.29  ? 129 VAL C CG2  1 
ATOM   1885 H  H    . VAL A 1 124 ? -32.292 -5.092  -18.974 1.00 47.73  ? 129 VAL C H    1 
ATOM   1886 H  HA   . VAL A 1 124 ? -34.329 -3.283  -19.447 1.00 43.68  ? 129 VAL C HA   1 
ATOM   1887 H  HB   . VAL A 1 124 ? -33.884 -1.955  -17.625 1.00 39.24  ? 129 VAL C HB   1 
ATOM   1888 H  HG11 . VAL A 1 124 ? -34.745 -3.155  -15.902 1.00 50.28  ? 129 VAL C HG11 1 
ATOM   1889 H  HG12 . VAL A 1 124 ? -35.388 -3.770  -17.214 1.00 50.28  ? 129 VAL C HG12 1 
ATOM   1890 H  HG13 . VAL A 1 124 ? -34.195 -4.523  -16.485 1.00 50.28  ? 129 VAL C HG13 1 
ATOM   1891 H  HG21 . VAL A 1 124 ? -32.318 -2.895  -15.920 1.00 47.19  ? 129 VAL C HG21 1 
ATOM   1892 H  HG22 . VAL A 1 124 ? -31.653 -3.583  -17.185 1.00 47.19  ? 129 VAL C HG22 1 
ATOM   1893 H  HG23 . VAL A 1 124 ? -31.752 -2.000  -17.101 1.00 47.19  ? 129 VAL C HG23 1 
ATOM   1894 N  N    . GLU A 1 125 ? -32.771 -1.379  -20.128 1.00 37.13  ? 130 GLU C N    1 
ATOM   1895 C  CA   . GLU A 1 125 ? -31.828 -0.399  -20.704 1.00 35.45  ? 130 GLU C CA   1 
ATOM   1896 C  C    . GLU A 1 125 ? -31.947 0.812   -19.771 1.00 33.71  ? 130 GLU C C    1 
ATOM   1897 O  O    . GLU A 1 125 ? -33.070 1.083   -19.348 1.00 35.83  ? 130 GLU C O    1 
ATOM   1898 C  CB   . GLU A 1 125 ? -32.202 -0.040  -22.135 1.00 37.71  ? 130 GLU C CB   1 
ATOM   1899 C  CG   . GLU A 1 125 ? -31.843 -1.106  -23.163 1.00 40.25  ? 130 GLU C CG   1 
ATOM   1900 C  CD   . GLU A 1 125 ? -32.473 -0.884  -24.529 1.00 46.42  ? 130 GLU C CD   1 
ATOM   1901 O  OE1  . GLU A 1 125 ? -33.081 0.176   -24.780 1.00 55.27  ? 130 GLU C OE1  1 
ATOM   1902 O  OE2  . GLU A 1 125 ? -32.346 -1.796  -25.363 1.00 57.21  ? 130 GLU C OE2  1 
ATOM   1903 H  H    . GLU A 1 125 ? -33.620 -1.089  -20.039 1.00 44.60  ? 130 GLU C H    1 
ATOM   1904 H  HA   . GLU A 1 125 ? -30.907 -0.756  -20.664 1.00 42.58  ? 130 GLU C HA   1 
ATOM   1905 H  HB2  . GLU A 1 125 ? -33.168 0.121   -22.167 1.00 45.29  ? 130 GLU C HB2  1 
ATOM   1906 H  HB3  . GLU A 1 125 ? -31.750 0.794   -22.375 1.00 45.29  ? 130 GLU C HB3  1 
ATOM   1907 H  HG2  . GLU A 1 125 ? -30.868 -1.132  -23.269 1.00 48.34  ? 130 GLU C HG2  1 
ATOM   1908 H  HG3  . GLU A 1 125 ? -32.125 -1.984  -22.827 1.00 48.34  ? 130 GLU C HG3  1 
ATOM   1909 N  N    . TYR A 1 126 ? -30.855 1.477   -19.427 1.00 33.39  ? 131 TYR C N    1 
ATOM   1910 C  CA   . TYR A 1 126 ? -30.930 2.585   -18.445 1.00 40.32  ? 131 TYR C CA   1 
ATOM   1911 C  C    . TYR A 1 126 ? -29.803 3.578   -18.555 1.00 40.40  ? 131 TYR C C    1 
ATOM   1912 O  O    . TYR A 1 126 ? -28.803 3.241   -19.194 1.00 36.50  ? 131 TYR C O    1 
ATOM   1913 C  CB   . TYR A 1 126 ? -30.875 2.042   -17.018 1.00 30.54  ? 131 TYR C CB   1 
ATOM   1914 C  CG   . TYR A 1 126 ? -29.559 1.384   -16.640 1.00 41.17  ? 131 TYR C CG   1 
ATOM   1915 C  CD1  . TYR A 1 126 ? -28.550 2.104   -16.018 1.00 37.50  ? 131 TYR C CD1  1 
ATOM   1916 C  CD2  . TYR A 1 126 ? -29.338 0.038   -16.894 1.00 39.86  ? 131 TYR C CD2  1 
ATOM   1917 C  CE1  . TYR A 1 126 ? -27.354 1.506   -15.668 1.00 48.16  ? 131 TYR C CE1  1 
ATOM   1918 C  CE2  . TYR A 1 126 ? -28.151 -0.575  -16.537 1.00 38.46  ? 131 TYR C CE2  1 
ATOM   1919 C  CZ   . TYR A 1 126 ? -27.155 0.164   -15.929 1.00 39.93  ? 131 TYR C CZ   1 
ATOM   1920 O  OH   . TYR A 1 126 ? -25.981 -0.426  -15.582 1.00 58.44  ? 131 TYR C OH   1 
ATOM   1921 H  H    . TYR A 1 126 ? -30.044 1.274   -19.766 1.00 40.11  ? 131 TYR C H    1 
ATOM   1922 H  HA   . TYR A 1 126 ? -31.779 3.060   -18.577 1.00 48.43  ? 131 TYR C HA   1 
ATOM   1923 H  HB2  . TYR A 1 126 ? -31.047 2.783   -16.396 1.00 36.69  ? 131 TYR C HB2  1 
ATOM   1924 H  HB3  . TYR A 1 126 ? -31.599 1.387   -16.905 1.00 36.69  ? 131 TYR C HB3  1 
ATOM   1925 H  HD1  . TYR A 1 126 ? -28.680 3.022   -15.837 1.00 45.05  ? 131 TYR C HD1  1 
ATOM   1926 H  HD2  . TYR A 1 126 ? -30.016 -0.472  -17.309 1.00 47.87  ? 131 TYR C HD2  1 
ATOM   1927 H  HE1  . TYR A 1 126 ? -26.677 2.011   -15.249 1.00 57.84  ? 131 TYR C HE1  1 
ATOM   1928 H  HE2  . TYR A 1 126 ? -28.016 -1.489  -16.722 1.00 46.19  ? 131 TYR C HE2  1 
ATOM   1929 H  HH   . TYR A 1 126 ? -25.820 -0.277  -14.751 1.00 70.17  ? 131 TYR C HH   1 
ATOM   1930 N  N    . THR A 1 127 ? -29.972 4.763   -17.973 1.00 34.94  ? 132 THR C N    1 
ATOM   1931 C  CA   . THR A 1 127 ? -28.922 5.788   -17.863 1.00 36.11  ? 132 THR C CA   1 
ATOM   1932 C  C    . THR A 1 127 ? -29.022 6.365   -16.466 1.00 39.90  ? 132 THR C C    1 
ATOM   1933 O  O    . THR A 1 127 ? -30.134 6.749   -16.088 1.00 40.16  ? 132 THR C O    1 
ATOM   1934 C  CB   . THR A 1 127 ? -29.047 6.873   -18.928 1.00 41.71  ? 132 THR C CB   1 
ATOM   1935 O  OG1  . THR A 1 127 ? -29.155 6.219   -20.185 1.00 49.46  ? 132 THR C OG1  1 
ATOM   1936 C  CG2  . THR A 1 127 ? -27.833 7.778   -18.946 1.00 40.27  ? 132 THR C CG2  1 
ATOM   1937 H  H    . THR A 1 127 ? -30.748 5.024   -17.594 1.00 41.97  ? 132 THR C H    1 
ATOM   1938 H  HA   . THR A 1 127 ? -28.048 5.354   -17.962 1.00 43.37  ? 132 THR C HA   1 
ATOM   1939 H  HB   . THR A 1 127 ? -29.860 7.408   -18.764 1.00 50.10  ? 132 THR C HB   1 
ATOM   1940 H  HG1  . THR A 1 127 ? -28.396 6.268   -20.593 1.00 59.39  ? 132 THR C HG1  1 
ATOM   1941 H  HG21 . THR A 1 127 ? -27.791 8.249   -19.795 1.00 48.37  ? 132 THR C HG21 1 
ATOM   1942 H  HG22 . THR A 1 127 ? -27.895 8.421   -18.220 1.00 48.37  ? 132 THR C HG22 1 
ATOM   1943 H  HG23 . THR A 1 127 ? -27.029 7.242   -18.834 1.00 48.37  ? 132 THR C HG23 1 
ATOM   1944 N  N    . GLY A 1 128 ? -27.926 6.394   -15.718 1.00 36.73  ? 133 GLY C N    1 
ATOM   1945 C  CA   . GLY A 1 128 ? -27.869 6.964   -14.363 1.00 37.52  ? 133 GLY C CA   1 
ATOM   1946 C  C    . GLY A 1 128 ? -27.079 8.256   -14.341 1.00 36.06  ? 133 GLY C C    1 
ATOM   1947 O  O    . GLY A 1 128 ? -25.965 8.268   -14.883 1.00 39.24  ? 133 GLY C O    1 
ATOM   1948 H  H    . GLY A 1 128 ? -27.149 6.052   -16.018 1.00 44.12  ? 133 GLY C H    1 
ATOM   1949 H  HA2  . GLY A 1 128 ? -28.783 7.129   -14.034 1.00 45.06  ? 133 GLY C HA2  1 
ATOM   1950 H  HA3  . GLY A 1 128 ? -27.445 6.310   -13.760 1.00 45.06  ? 133 GLY C HA3  1 
ATOM   1951 N  N    . ARG A 1 129 ? -27.616 9.300   -13.719 1.00 33.05  ? 134 ARG C N    1 
ATOM   1952 C  CA   . ARG A 1 129 ? -26.958 10.623  -13.664 1.00 39.36  ? 134 ARG C CA   1 
ATOM   1953 C  C    . ARG A 1 129 ? -27.103 11.268  -12.285 1.00 45.31  ? 134 ARG C C    1 
ATOM   1954 O  O    . ARG A 1 129 ? -28.051 10.923  -11.572 1.00 39.59  ? 134 ARG C O    1 
ATOM   1955 C  CB   . ARG A 1 129 ? -27.552 11.594  -14.688 1.00 44.88  ? 134 ARG C CB   1 
ATOM   1956 C  CG   . ARG A 1 129 ? -28.983 12.058  -14.478 1.00 47.00  ? 134 ARG C CG   1 
ATOM   1957 C  CD   . ARG A 1 129 ? -29.349 12.982  -15.613 1.00 50.99  ? 134 ARG C CD   1 
ATOM   1958 N  NE   . ARG A 1 129 ? -30.561 13.754  -15.329 1.00 42.96  ? 134 ARG C NE   1 
ATOM   1959 C  CZ   . ARG A 1 129 ? -31.796 13.338  -15.544 1.00 56.36  ? 134 ARG C CZ   1 
ATOM   1960 N  NH1  . ARG A 1 129 ? -32.022 12.189  -16.150 1.00 52.31  ? 134 ARG C NH1  1 
ATOM   1961 N  NH2  . ARG A 1 129 ? -32.811 14.075  -15.141 1.00 53.99  ? 134 ARG C NH2  1 
ATOM   1962 H  H    . ARG A 1 129 ? -28.406 9.241   -13.292 1.00 39.71  ? 134 ARG C H    1 
ATOM   1963 H  HA   . ARG A 1 129 ? -25.997 10.499  -13.858 1.00 47.28  ? 134 ARG C HA   1 
ATOM   1964 H  HB2  . ARG A 1 129 ? -26.976 12.389  -14.712 1.00 53.90  ? 134 ARG C HB2  1 
ATOM   1965 H  HB3  . ARG A 1 129 ? -27.495 11.172  -15.571 1.00 53.90  ? 134 ARG C HB3  1 
ATOM   1966 H  HG2  . ARG A 1 129 ? -29.590 11.287  -14.471 1.00 56.45  ? 134 ARG C HG2  1 
ATOM   1967 H  HG3  . ARG A 1 129 ? -29.065 12.541  -13.628 1.00 56.45  ? 134 ARG C HG3  1 
ATOM   1968 H  HD2  . ARG A 1 129 ? -28.604 13.598  -15.766 1.00 61.23  ? 134 ARG C HD2  1 
ATOM   1969 H  HD3  . ARG A 1 129 ? -29.476 12.458  -16.429 1.00 61.23  ? 134 ARG C HD3  1 
ATOM   1970 H  HE   . ARG A 1 129 ? -30.463 14.547  -14.985 1.00 51.60  ? 134 ARG C HE   1 
ATOM   1971 H  HH11 . ARG A 1 129 ? -32.022 11.441  -15.680 1.00 62.82  ? 134 ARG C HH11 1 
ATOM   1972 H  HH12 . ARG A 1 129 ? -32.172 12.174  -17.019 1.00 62.82  ? 134 ARG C HH12 1 
ATOM   1973 H  HH21 . ARG A 1 129 ? -32.753 14.955  -15.168 1.00 64.84  ? 134 ARG C HH21 1 
ATOM   1974 H  HH22 . ARG A 1 129 ? -33.542 13.680  -14.840 1.00 64.84  ? 134 ARG C HH22 1 
ATOM   1975 N  N    . LEU A 1 130 ? -26.197 12.177  -11.946 1.00 43.62  ? 135 LEU C N    1 
ATOM   1976 C  CA   . LEU A 1 130 ? -26.250 12.948  -10.685 1.00 42.51  ? 135 LEU C CA   1 
ATOM   1977 C  C    . LEU A 1 130 ? -27.140 14.176  -10.920 1.00 44.48  ? 135 LEU C C    1 
ATOM   1978 O  O    . LEU A 1 130 ? -27.537 14.384  -12.076 1.00 44.30  ? 135 LEU C O    1 
ATOM   1979 C  CB   . LEU A 1 130 ? -24.815 13.315  -10.330 1.00 40.26  ? 135 LEU C CB   1 
ATOM   1980 C  CG   . LEU A 1 130 ? -23.835 12.156  -10.140 1.00 44.56  ? 135 LEU C CG   1 
ATOM   1981 C  CD1  . LEU A 1 130 ? -22.422 12.687  -10.112 1.00 49.15  ? 135 LEU C CD1  1 
ATOM   1982 C  CD2  . LEU A 1 130 ? -24.144 11.385  -8.880  1.00 44.56  ? 135 LEU C CD2  1 
ATOM   1983 H  H    . LEU A 1 130 ? -25.506 12.375  -12.491 1.00 52.38  ? 135 LEU C H    1 
ATOM   1984 H  HA   . LEU A 1 130 ? -26.639 12.385  -9.970  1.00 51.05  ? 135 LEU C HA   1 
ATOM   1985 H  HB2  . LEU A 1 130 ? -24.469 13.886  -11.050 1.00 48.35  ? 135 LEU C HB2  1 
ATOM   1986 H  HB3  . LEU A 1 130 ? -24.830 13.849  -9.503  1.00 48.35  ? 135 LEU C HB3  1 
ATOM   1987 H  HG   . LEU A 1 130 ? -23.918 11.542  -10.913 1.00 53.52  ? 135 LEU C HG   1 
ATOM   1988 H  HD11 . LEU A 1 130 ? -21.801 11.972  -10.329 1.00 59.02  ? 135 LEU C HD11 1 
ATOM   1989 H  HD12 . LEU A 1 130 ? -22.332 13.403  -10.764 1.00 59.02  ? 135 LEU C HD12 1 
ATOM   1990 H  HD13 . LEU A 1 130 ? -22.223 13.030  -9.225  1.00 59.02  ? 135 LEU C HD13 1 
ATOM   1991 H  HD21 . LEU A 1 130 ? -23.318 11.195  -8.404  1.00 53.51  ? 135 LEU C HD21 1 
ATOM   1992 H  HD22 . LEU A 1 130 ? -24.729 11.914  -8.313  1.00 53.51  ? 135 LEU C HD22 1 
ATOM   1993 H  HD23 . LEU A 1 130 ? -24.585 10.550  -9.110  1.00 53.51  ? 135 LEU C HD23 1 
ATOM   1994 N  N    . ILE A 1 131 ? -27.427 14.966  -9.892  1.00 42.15  ? 136 ILE C N    1 
ATOM   1995 C  CA   . ILE A 1 131 ? -28.358 16.133  -9.991  1.00 41.04  ? 136 ILE C CA   1 
ATOM   1996 C  C    . ILE A 1 131 ? -27.711 17.225  -10.859 1.00 44.46  ? 136 ILE C C    1 
ATOM   1997 O  O    . ILE A 1 131 ? -28.459 18.025  -11.428 1.00 47.38  ? 136 ILE C O    1 
ATOM   1998 C  CB   . ILE A 1 131 ? -28.741 16.613  -8.578  1.00 44.70  ? 136 ILE C CB   1 
ATOM   1999 C  CG1  . ILE A 1 131 ? -29.563 15.559  -7.838  1.00 45.12  ? 136 ILE C CG1  1 
ATOM   2000 C  CG2  . ILE A 1 131 ? -29.481 17.948  -8.609  1.00 46.14  ? 136 ILE C CG2  1 
ATOM   2001 C  CD1  . ILE A 1 131 ? -29.486 15.660  -6.327  1.00 47.11  ? 136 ILE C CD1  1 
ATOM   2002 H  H    . ILE A 1 131 ? -27.063 14.831  -9.078  1.00 50.62  ? 136 ILE C H    1 
ATOM   2003 H  HA   . ILE A 1 131 ? -29.172 15.832  -10.436 1.00 49.29  ? 136 ILE C HA   1 
ATOM   2004 H  HB   . ILE A 1 131 ? -27.913 16.743  -8.079  1.00 53.68  ? 136 ILE C HB   1 
ATOM   2005 H  HG12 . ILE A 1 131 ? -30.499 15.647  -8.110  1.00 54.19  ? 136 ILE C HG12 1 
ATOM   2006 H  HG13 . ILE A 1 131 ? -29.257 14.670  -8.108  1.00 54.19  ? 136 ILE C HG13 1 
ATOM   2007 H  HG21 . ILE A 1 131 ? -29.950 18.079  -7.767  1.00 55.41  ? 136 ILE C HG21 1 
ATOM   2008 H  HG22 . ILE A 1 131 ? -28.847 18.672  -8.740  1.00 55.41  ? 136 ILE C HG22 1 
ATOM   2009 H  HG23 . ILE A 1 131 ? -30.127 17.944  -9.335  1.00 55.41  ? 136 ILE C HG23 1 
ATOM   2010 H  HD11 . ILE A 1 131 ? -29.570 14.768  -5.940  1.00 56.57  ? 136 ILE C HD11 1 
ATOM   2011 H  HD12 . ILE A 1 131 ? -28.628 16.046  -6.068  1.00 56.57  ? 136 ILE C HD12 1 
ATOM   2012 H  HD13 . ILE A 1 131 ? -30.209 16.226  -5.997  1.00 56.57  ? 136 ILE C HD13 1 
ATOM   2013 N  N    . ASP A 1 132 ? -26.386 17.218  -11.003 1.00 54.37  ? 137 ASP C N    1 
ATOM   2014 C  CA   . ASP A 1 132 ? -25.637 18.197  -11.843 1.00 51.81  ? 137 ASP C CA   1 
ATOM   2015 C  C    . ASP A 1 132 ? -25.723 17.810  -13.324 1.00 55.69  ? 137 ASP C C    1 
ATOM   2016 O  O    . ASP A 1 132 ? -25.374 18.662  -14.152 1.00 58.26  ? 137 ASP C O    1 
ATOM   2017 C  CB   . ASP A 1 132 ? -24.201 18.340  -11.363 1.00 45.90  ? 137 ASP C CB   1 
ATOM   2018 C  CG   . ASP A 1 132 ? -23.299 17.127  -11.507 1.00 51.35  ? 137 ASP C CG   1 
ATOM   2019 O  OD1  . ASP A 1 132 ? -23.794 16.080  -11.936 1.00 59.07  ? 137 ASP C OD1  1 
ATOM   2020 O  OD2  . ASP A 1 132 ? -22.108 17.250  -11.178 1.00 66.53  ? 137 ASP C OD2  1 
ATOM   2021 H  H    . ASP A 1 132 ? -25.875 16.608  -10.579 1.00 65.29  ? 137 ASP C H    1 
ATOM   2022 H  HA   . ASP A 1 132 ? -26.060 19.076  -11.733 1.00 62.22  ? 137 ASP C HA   1 
ATOM   2023 H  HB2  . ASP A 1 132 ? -23.784 19.082  -11.847 1.00 55.12  ? 137 ASP C HB2  1 
ATOM   2024 H  HB3  . ASP A 1 132 ? -24.228 18.576  -10.413 1.00 55.12  ? 137 ASP C HB3  1 
ATOM   2025 N  N    . GLY A 1 133 ? -26.134 16.581  -13.644 1.00 52.74  ? 138 GLY C N    1 
ATOM   2026 C  CA   . GLY A 1 133 ? -26.307 16.114  -15.033 1.00 46.49  ? 138 GLY C CA   1 
ATOM   2027 C  C    . GLY A 1 133 ? -25.189 15.196  -15.457 1.00 45.62  ? 138 GLY C C    1 
ATOM   2028 O  O    . GLY A 1 133 ? -25.274 14.660  -16.568 1.00 53.31  ? 138 GLY C O    1 
ATOM   2029 H  H    . GLY A 1 133 ? -26.306 15.964  -13.006 1.00 63.33  ? 138 GLY C H    1 
ATOM   2030 H  HA2  . GLY A 1 133 ? -27.166 15.632  -15.101 1.00 55.84  ? 138 GLY C HA2  1 
ATOM   2031 H  HA3  . GLY A 1 133 ? -26.346 16.887  -15.639 1.00 55.84  ? 138 GLY C HA3  1 
ATOM   2032 N  N    . THR A 1 134 ? -24.179 15.009  -14.617 1.00 54.84  ? 139 THR C N    1 
ATOM   2033 C  CA   . THR A 1 134 ? -23.048 14.111  -14.891 1.00 46.17  ? 139 THR C CA   1 
ATOM   2034 C  C    . THR A 1 134 ? -23.560 12.701  -14.980 1.00 50.84  ? 139 THR C C    1 
ATOM   2035 O  O    . THR A 1 134 ? -24.059 12.212  -13.967 1.00 48.49  ? 139 THR C O    1 
ATOM   2036 C  CB   . THR A 1 134 ? -21.998 14.240  -13.792 1.00 50.07  ? 139 THR C CB   1 
ATOM   2037 O  OG1  . THR A 1 134 ? -21.399 15.519  -13.963 1.00 59.74  ? 139 THR C OG1  1 
ATOM   2038 C  CG2  . THR A 1 134 ? -20.938 13.159  -13.875 1.00 47.75  ? 139 THR C CG2  1 
ATOM   2039 H  H    . THR A 1 134 ? -24.117 15.408  -13.812 1.00 65.85  ? 139 THR C H    1 
ATOM   2040 H  HA   . THR A 1 134 ? -22.644 14.362  -15.748 1.00 55.45  ? 139 THR C HA   1 
ATOM   2041 H  HB   . THR A 1 134 ? -22.430 14.188  -12.906 1.00 60.13  ? 139 THR C HB   1 
ATOM   2042 H  HG1  . THR A 1 134 ? -21.955 16.140  -13.745 1.00 71.73  ? 139 THR C HG1  1 
ATOM   2043 H  HG21 . THR A 1 134 ? -20.112 13.485  -13.480 1.00 57.35  ? 139 THR C HG21 1 
ATOM   2044 H  HG22 . THR A 1 134 ? -21.237 12.371  -13.391 1.00 57.35  ? 139 THR C HG22 1 
ATOM   2045 H  HG23 . THR A 1 134 ? -20.781 12.928  -14.807 1.00 57.35  ? 139 THR C HG23 1 
ATOM   2046 N  N    . VAL A 1 135 ? -23.415 12.055  -16.130 1.00 47.58  ? 140 VAL C N    1 
ATOM   2047 C  CA   . VAL A 1 135 ? -23.798 10.627  -16.303 1.00 41.88  ? 140 VAL C CA   1 
ATOM   2048 C  C    . VAL A 1 135 ? -22.676 9.749   -15.740 1.00 51.94  ? 140 VAL C C    1 
ATOM   2049 O  O    . VAL A 1 135 ? -21.510 10.053  -16.019 1.00 57.69  ? 140 VAL C O    1 
ATOM   2050 C  CB   . VAL A 1 135 ? -24.069 10.312  -17.778 1.00 41.75  ? 140 VAL C CB   1 
ATOM   2051 C  CG1  . VAL A 1 135 ? -24.275 8.822   -18.014 1.00 50.67  ? 140 VAL C CG1  1 
ATOM   2052 C  CG2  . VAL A 1 135 ? -25.250 11.117  -18.296 1.00 52.15  ? 140 VAL C CG2  1 
ATOM   2053 H  H    . VAL A 1 135 ? -23.072 12.459  -16.860 1.00 57.14  ? 140 VAL C H    1 
ATOM   2054 H  HA   . VAL A 1 135 ? -24.615 10.458  -15.794 1.00 50.30  ? 140 VAL C HA   1 
ATOM   2055 H  HB   . VAL A 1 135 ? -23.271 10.591  -18.283 1.00 50.15  ? 140 VAL C HB   1 
ATOM   2056 H  HG11 . VAL A 1 135 ? -23.897 8.574   -18.874 1.00 60.85  ? 140 VAL C HG11 1 
ATOM   2057 H  HG12 . VAL A 1 135 ? -23.835 8.315   -17.309 1.00 60.85  ? 140 VAL C HG12 1 
ATOM   2058 H  HG13 . VAL A 1 135 ? -25.226 8.619   -18.009 1.00 60.85  ? 140 VAL C HG13 1 
ATOM   2059 H  HG21 . VAL A 1 135 ? -25.711 10.612  -18.985 1.00 62.62  ? 140 VAL C HG21 1 
ATOM   2060 H  HG22 . VAL A 1 135 ? -25.863 11.300  -17.563 1.00 62.62  ? 140 VAL C HG22 1 
ATOM   2061 H  HG23 . VAL A 1 135 ? -24.932 11.957  -18.667 1.00 62.62  ? 140 VAL C HG23 1 
ATOM   2062 N  N    . PHE A 1 136 ? -23.017 8.704   -14.990 1.00 49.56  ? 141 PHE C N    1 
ATOM   2063 C  CA   . PHE A 1 136 ? -22.015 7.814   -14.349 1.00 40.44  ? 141 PHE C CA   1 
ATOM   2064 C  C    . PHE A 1 136 ? -22.150 6.388   -14.870 1.00 47.33  ? 141 PHE C C    1 
ATOM   2065 O  O    . PHE A 1 136 ? -21.222 5.602   -14.636 1.00 48.45  ? 141 PHE C O    1 
ATOM   2066 C  CB   . PHE A 1 136 ? -22.193 7.904   -12.831 1.00 47.25  ? 141 PHE C CB   1 
ATOM   2067 C  CG   . PHE A 1 136 ? -23.549 7.512   -12.258 1.00 42.35  ? 141 PHE C CG   1 
ATOM   2068 C  CD1  . PHE A 1 136 ? -23.906 6.179   -12.106 1.00 36.40  ? 141 PHE C CD1  1 
ATOM   2069 C  CD2  . PHE A 1 136 ? -24.449 8.482   -11.834 1.00 41.70  ? 141 PHE C CD2  1 
ATOM   2070 C  CE1  . PHE A 1 136 ? -25.135 5.831   -11.571 1.00 42.43  ? 141 PHE C CE1  1 
ATOM   2071 C  CE2  . PHE A 1 136 ? -25.674 8.125   -11.298 1.00 42.90  ? 141 PHE C CE2  1 
ATOM   2072 C  CZ   . PHE A 1 136 ? -26.014 6.804   -11.167 1.00 40.65  ? 141 PHE C CZ   1 
ATOM   2073 H  H    . PHE A 1 136 ? -23.882 8.500   -14.835 1.00 59.51  ? 141 PHE C H    1 
ATOM   2074 H  HA   . PHE A 1 136 ? -21.108 8.148   -14.579 1.00 48.58  ? 141 PHE C HA   1 
ATOM   2075 H  HB2  . PHE A 1 136 ? -21.508 7.338   -12.412 1.00 56.74  ? 141 PHE C HB2  1 
ATOM   2076 H  HB3  . PHE A 1 136 ? -22.001 8.830   -12.561 1.00 56.74  ? 141 PHE C HB3  1 
ATOM   2077 H  HD1  . PHE A 1 136 ? -23.308 5.504   -12.383 1.00 43.73  ? 141 PHE C HD1  1 
ATOM   2078 H  HD2  . PHE A 1 136 ? -24.224 9.396   -11.921 1.00 50.09  ? 141 PHE C HD2  1 
ATOM   2079 H  HE1  . PHE A 1 136 ? -25.368 4.921   -11.483 1.00 50.96  ? 141 PHE C HE1  1 
ATOM   2080 H  HE2  . PHE A 1 136 ? -26.278 8.797   -11.022 1.00 51.52  ? 141 PHE C HE2  1 
ATOM   2081 H  HZ   . PHE A 1 136 ? -26.851 6.564   -10.803 1.00 48.83  ? 141 PHE C HZ   1 
ATOM   2082 N  N    . ASP A 1 137 ? -23.250 6.058   -15.545 1.00 41.26  ? 142 ASP C N    1 
ATOM   2083 C  CA   . ASP A 1 137 ? -23.494 4.677   -16.045 1.00 48.10  ? 142 ASP C CA   1 
ATOM   2084 C  C    . ASP A 1 137 ? -24.591 4.666   -17.112 1.00 43.18  ? 142 ASP C C    1 
ATOM   2085 O  O    . ASP A 1 137 ? -25.507 5.482   -17.002 1.00 45.11  ? 142 ASP C O    1 
ATOM   2086 C  CB   . ASP A 1 137 ? -23.834 3.729   -14.906 1.00 41.32  ? 142 ASP C CB   1 
ATOM   2087 C  CG   . ASP A 1 137 ? -23.587 2.249   -15.154 1.00 56.13  ? 142 ASP C CG   1 
ATOM   2088 O  OD1  . ASP A 1 137 ? -22.911 1.915   -16.146 1.00 60.46  ? 142 ASP C OD1  1 
ATOM   2089 O  OD2  . ASP A 1 137 ? -24.075 1.439   -14.345 1.00 58.09  ? 142 ASP C OD2  1 
ATOM   2090 H  H    . ASP A 1 137 ? -23.899 6.661   -15.715 1.00 49.56  ? 142 ASP C H    1 
ATOM   2091 H  HA   . ASP A 1 137 ? -22.665 4.366   -16.466 1.00 57.76  ? 142 ASP C HA   1 
ATOM   2092 H  HB2  . ASP A 1 137 ? -23.332 3.987   -14.106 1.00 49.63  ? 142 ASP C HB2  1 
ATOM   2093 H  HB3  . ASP A 1 137 ? -24.786 3.837   -14.702 1.00 49.63  ? 142 ASP C HB3  1 
ATOM   2094 N  N    . SER A 1 138 ? -24.488 3.778   -18.102 1.00 45.94  ? 143 SER C N    1 
ATOM   2095 C  CA   . SER A 1 138 ? -25.504 3.632   -19.175 1.00 46.17  ? 143 SER C CA   1 
ATOM   2096 C  C    . SER A 1 138 ? -25.298 2.346   -19.977 1.00 53.50  ? 143 SER C C    1 
ATOM   2097 O  O    . SER A 1 138 ? -24.135 1.954   -20.150 1.00 51.86  ? 143 SER C O    1 
ATOM   2098 C  CB   . SER A 1 138 ? -25.508 4.788   -20.124 1.00 51.78  ? 143 SER C CB   1 
ATOM   2099 O  OG   . SER A 1 138 ? -26.662 4.738   -20.945 1.00 60.73  ? 143 SER C OG   1 
ATOM   2100 H  H    . SER A 1 138 ? -23.782 3.219   -18.159 1.00 55.17  ? 143 SER C H    1 
ATOM   2101 H  HA   . SER A 1 138 ? -26.388 3.583   -18.743 1.00 55.45  ? 143 SER C HA   1 
ATOM   2102 H  HB2  . SER A 1 138 ? -25.502 5.625   -19.626 1.00 62.18  ? 143 SER C HB2  1 
ATOM   2103 H  HB3  . SER A 1 138 ? -24.709 4.752   -20.683 1.00 62.18  ? 143 SER C HB3  1 
ATOM   2104 H  HG   . SER A 1 138 ? -27.300 4.412   -20.496 1.00 72.92  ? 143 SER C HG   1 
ATOM   2105 N  N    . THR A 1 139 ? -26.377 1.732   -20.459 1.00 48.74  ? 144 THR C N    1 
ATOM   2106 C  CA   . THR A 1 139 ? -26.327 0.558   -21.345 1.00 43.52  ? 144 THR C CA   1 
ATOM   2107 C  C    . THR A 1 139 ? -26.077 1.089   -22.733 1.00 55.18  ? 144 THR C C    1 
ATOM   2108 O  O    . THR A 1 139 ? -25.664 0.303   -23.587 1.00 54.54  ? 144 THR C O    1 
ATOM   2109 C  CB   . THR A 1 139 ? -27.639 -0.221  -21.268 1.00 45.86  ? 144 THR C CB   1 
ATOM   2110 O  OG1  . THR A 1 139 ? -28.665 0.745   -21.465 1.00 45.30  ? 144 THR C OG1  1 
ATOM   2111 C  CG2  . THR A 1 139 ? -27.834 -0.936  -19.945 1.00 44.29  ? 144 THR C CG2  1 
ATOM   2112 H  H    . THR A 1 139 ? -27.221 1.989   -20.273 1.00 58.53  ? 144 THR C H    1 
ATOM   2113 H  HA   . THR A 1 139 ? -25.585 -0.025  -21.075 1.00 52.27  ? 144 THR C HA   1 
ATOM   2114 H  HB   . THR A 1 139 ? -27.670 -0.883  -21.999 1.00 55.08  ? 144 THR C HB   1 
ATOM   2115 H  HG1  . THR A 1 139 ? -29.301 0.406   -21.939 1.00 54.41  ? 144 THR C HG1  1 
ATOM   2116 H  HG21 . THR A 1 139 ? -28.775 -0.909  -19.698 1.00 53.19  ? 144 THR C HG21 1 
ATOM   2117 H  HG22 . THR A 1 139 ? -27.549 -1.862  -20.030 1.00 53.19  ? 144 THR C HG22 1 
ATOM   2118 H  HG23 . THR A 1 139 ? -27.307 -0.497  -19.257 1.00 53.19  ? 144 THR C HG23 1 
ATOM   2119 N  N    . GLU A 1 140 ? -26.305 2.386   -22.949 1.00 61.83  ? 145 GLU C N    1 
ATOM   2120 C  CA   . GLU A 1 140 ? -26.131 3.045   -24.268 1.00 69.05  ? 145 GLU C CA   1 
ATOM   2121 C  C    . GLU A 1 140 ? -24.669 2.959   -24.695 1.00 71.62  ? 145 GLU C C    1 
ATOM   2122 O  O    . GLU A 1 140 ? -24.406 3.175   -25.889 1.00 76.94  ? 145 GLU C O    1 
ATOM   2123 C  CB   . GLU A 1 140 ? -26.587 4.499   -24.195 1.00 69.97  ? 145 GLU C CB   1 
ATOM   2124 C  CG   . GLU A 1 140 ? -25.514 5.463   -23.695 1.00 69.79  ? 145 GLU C CG   1 
ATOM   2125 C  CD   . GLU A 1 140 ? -26.055 6.755   -23.116 1.00 78.28  ? 145 GLU C CD   1 
ATOM   2126 O  OE1  . GLU A 1 140 ? -25.314 7.391   -22.335 1.00 81.59  ? 145 GLU C OE1  1 
ATOM   2127 O  OE2  . GLU A 1 140 ? -27.204 7.126   -23.436 1.00 80.96  ? 145 GLU C OE2  1 
ATOM   2128 H  H    . GLU A 1 140 ? -26.592 2.931   -22.291 1.00 74.23  ? 145 GLU C H    1 
ATOM   2129 H  HA   . GLU A 1 140 ? -26.685 2.564   -24.932 1.00 82.90  ? 145 GLU C HA   1 
ATOM   2130 H  HB2  . GLU A 1 140 ? -26.880 4.782   -25.085 1.00 84.01  ? 145 GLU C HB2  1 
ATOM   2131 H  HB3  . GLU A 1 140 ? -27.360 4.547   -23.597 1.00 84.01  ? 145 GLU C HB3  1 
ATOM   2132 H  HG2  . GLU A 1 140 ? -24.980 5.019   -23.004 1.00 83.79  ? 145 GLU C HG2  1 
ATOM   2133 H  HG3  . GLU A 1 140 ? -24.913 5.685   -24.437 1.00 83.79  ? 145 GLU C HG3  1 
ATOM   2134 N  N    . LYS A 1 141 ? -23.759 2.731   -23.753 1.00 72.49  ? 146 LYS C N    1 
ATOM   2135 C  CA   . LYS A 1 141 ? -22.342 2.508   -24.096 1.00 73.70  ? 146 LYS C CA   1 
ATOM   2136 C  C    . LYS A 1 141 ? -22.232 1.089   -24.641 1.00 76.48  ? 146 LYS C C    1 
ATOM   2137 O  O    . LYS A 1 141 ? -21.907 0.955   -25.832 1.00 79.33  ? 146 LYS C O    1 
ATOM   2138 C  CB   . LYS A 1 141 ? -21.475 2.680   -22.853 1.00 72.79  ? 146 LYS C CB   1 
ATOM   2139 C  CG   . LYS A 1 141 ? -21.252 4.119   -22.444 1.00 78.94  ? 146 LYS C CG   1 
ATOM   2140 C  CD   . LYS A 1 141 ? -20.097 4.270   -21.467 1.00 80.60  ? 146 LYS C CD   1 
ATOM   2141 C  CE   . LYS A 1 141 ? -18.779 4.211   -22.156 1.00 83.53  ? 146 LYS C CE   1 
ATOM   2142 N  NZ   . LYS A 1 141 ? -17.688 4.370   -21.196 1.00 87.27  ? 146 LYS C NZ   1 
ATOM   2143 H  H    . LYS A 1 141 ? -23.967 2.743   -22.875 1.00 87.03  ? 146 LYS C H    1 
ATOM   2144 H  HA   . LYS A 1 141 ? -22.068 3.155   -24.791 1.00 88.48  ? 146 LYS C HA   1 
ATOM   2145 H  HB2  . LYS A 1 141 ? -21.899 2.208   -22.105 1.00 87.40  ? 146 LYS C HB2  1 
ATOM   2146 H  HB3  . LYS A 1 141 ? -20.604 2.262   -23.016 1.00 87.40  ? 146 LYS C HB3  1 
ATOM   2147 H  HG2  . LYS A 1 141 ? -21.067 4.649   -23.247 1.00 94.77  ? 146 LYS C HG2  1 
ATOM   2148 H  HG3  . LYS A 1 141 ? -22.075 4.461   -22.031 1.00 94.77  ? 146 LYS C HG3  1 
ATOM   2149 H  HD2  . LYS A 1 141 ? -20.178 5.128   -20.999 1.00 96.77  ? 146 LYS C HD2  1 
ATOM   2150 H  HD3  . LYS A 1 141 ? -20.143 3.549   -20.802 1.00 96.77  ? 146 LYS C HD3  1 
ATOM   2151 H  HE2  . LYS A 1 141 ? -18.684 3.355   -22.609 1.00 100.29 ? 146 LYS C HE2  1 
ATOM   2152 H  HE3  . LYS A 1 141 ? -18.729 4.919   -22.822 1.00 100.29 ? 146 LYS C HE3  1 
ATOM   2153 H  HZ1  . LYS A 1 141 ? -16.893 4.272   -21.616 1.00 104.77 ? 146 LYS C HZ1  1 
ATOM   2154 H  HZ2  . LYS A 1 141 ? -17.735 5.193   -20.822 1.00 104.77 ? 146 LYS C HZ2  1 
ATOM   2155 H  HZ3  . LYS A 1 141 ? -17.768 3.743   -20.548 1.00 104.77 ? 146 LYS C HZ3  1 
ATOM   2156 N  N    . THR A 1 142 ? -22.555 0.081   -23.832 1.00 72.33  ? 147 THR C N    1 
ATOM   2157 C  CA   . THR A 1 142 ? -22.446 -1.341  -24.212 1.00 75.89  ? 147 THR C CA   1 
ATOM   2158 C  C    . THR A 1 142 ? -23.147 -1.588  -25.519 1.00 73.87  ? 147 THR C C    1 
ATOM   2159 O  O    . THR A 1 142 ? -22.722 -2.506  -26.236 1.00 80.24  ? 147 THR C O    1 
ATOM   2160 C  CB   . THR A 1 142 ? -23.065 -2.188  -23.112 1.00 77.45  ? 147 THR C CB   1 
ATOM   2161 O  OG1  . THR A 1 142 ? -22.575 -1.629  -21.898 1.00 82.41  ? 147 THR C OG1  1 
ATOM   2162 C  CG2  . THR A 1 142 ? -22.671 -3.647  -23.234 1.00 79.72  ? 147 THR C CG2  1 
ATOM   2163 H  H    . THR A 1 142 ? -22.899 0.192   -23.006 1.00 86.84  ? 147 THR C H    1 
ATOM   2164 H  HA   . THR A 1 142 ? -21.499 -1.574  -24.302 1.00 91.11  ? 147 THR C HA   1 
ATOM   2165 H  HB   . THR A 1 142 ? -24.048 -2.106  -23.144 1.00 92.98  ? 147 THR C HB   1 
ATOM   2166 H  HG1  . THR A 1 142 ? -23.107 -1.836  -21.250 1.00 98.93  ? 147 THR C HG1  1 
ATOM   2167 H  HG21 . THR A 1 142 ? -22.493 -4.010  -22.351 1.00 95.71  ? 147 THR C HG21 1 
ATOM   2168 H  HG22 . THR A 1 142 ? -23.395 -4.144  -23.648 1.00 95.71  ? 147 THR C HG22 1 
ATOM   2169 H  HG23 . THR A 1 142 ? -21.873 -3.722  -23.782 1.00 95.71  ? 147 THR C HG23 1 
ATOM   2170 N  N    . GLY A 1 143 ? -24.206 -0.839  -25.811 1.00 71.24  ? 148 GLY C N    1 
ATOM   2171 C  CA   . GLY A 1 143 ? -25.001 -1.028  -27.032 1.00 64.82  ? 148 GLY C CA   1 
ATOM   2172 C  C    . GLY A 1 143 ? -25.882 -2.239  -26.871 1.00 69.49  ? 148 GLY C C    1 
ATOM   2173 O  O    . GLY A 1 143 ? -26.444 -2.677  -27.889 1.00 65.41  ? 148 GLY C O    1 
ATOM   2174 H  H    . GLY A 1 143 ? -24.503 -0.199  -25.247 1.00 85.53  ? 148 GLY C H    1 
ATOM   2175 H  HA2  . GLY A 1 143 ? -25.555 -0.228  -27.187 1.00 77.83  ? 148 GLY C HA2  1 
ATOM   2176 H  HA3  . GLY A 1 143 ? -24.401 -1.145  -27.804 1.00 77.83  ? 148 GLY C HA3  1 
ATOM   2177 N  N    . LYS A 1 144 ? -26.015 -2.746  -25.644 1.00 58.78  ? 149 LYS C N    1 
ATOM   2178 C  CA   . LYS A 1 144 ? -26.794 -3.975  -25.380 1.00 59.42  ? 149 LYS C CA   1 
ATOM   2179 C  C    . LYS A 1 144 ? -27.558 -3.866  -24.063 1.00 57.24  ? 149 LYS C C    1 
ATOM   2180 O  O    . LYS A 1 144 ? -27.034 -3.236  -23.139 1.00 60.12  ? 149 LYS C O    1 
ATOM   2181 C  CB   . LYS A 1 144 ? -25.839 -5.157  -25.259 1.00 66.80  ? 149 LYS C CB   1 
ATOM   2182 C  CG   . LYS A 1 144 ? -25.336 -5.705  -26.578 1.00 76.03  ? 149 LYS C CG   1 
ATOM   2183 C  CD   . LYS A 1 144 ? -25.634 -7.184  -26.758 1.00 79.08  ? 149 LYS C CD   1 
ATOM   2184 C  CE   . LYS A 1 144 ? -25.052 -7.715  -28.022 1.00 80.87  ? 149 LYS C CE   1 
ATOM   2185 N  NZ   . LYS A 1 144 ? -26.108 -8.169  -28.926 1.00 73.66  ? 149 LYS C NZ   1 
ATOM   2186 H  H    . LYS A 1 144 ? -25.658 -2.345  -24.919 1.00 70.58  ? 149 LYS C H    1 
ATOM   2187 H  HA   . LYS A 1 144 ? -27.420 -4.126  -26.125 1.00 71.34  ? 149 LYS C HA   1 
ATOM   2188 H  HB2  . LYS A 1 144 ? -25.067 -4.880  -24.723 1.00 80.21  ? 149 LYS C HB2  1 
ATOM   2189 H  HB3  . LYS A 1 144 ? -26.294 -5.879  -24.777 1.00 80.21  ? 149 LYS C HB3  1 
ATOM   2190 H  HG2  . LYS A 1 144 ? -25.758 -5.204  -27.307 1.00 91.28  ? 149 LYS C HG2  1 
ATOM   2191 H  HG3  . LYS A 1 144 ? -24.367 -5.561  -26.631 1.00 91.28  ? 149 LYS C HG3  1 
ATOM   2192 H  HD2  . LYS A 1 144 ? -25.266 -7.682  -25.997 1.00 94.93  ? 149 LYS C HD2  1 
ATOM   2193 H  HD3  . LYS A 1 144 ? -26.607 -7.315  -26.772 1.00 94.93  ? 149 LYS C HD3  1 
ATOM   2194 H  HE2  . LYS A 1 144 ? -24.539 -7.013  -28.459 1.00 97.09  ? 149 LYS C HE2  1 
ATOM   2195 H  HE3  . LYS A 1 144 ? -24.456 -8.460  -27.828 1.00 97.09  ? 149 LYS C HE3  1 
ATOM   2196 H  HZ1  . LYS A 1 144 ? -25.746 -8.448  -29.707 1.00 88.43  ? 149 LYS C HZ1  1 
ATOM   2197 H  HZ2  . LYS A 1 144 ? -26.560 -8.853  -28.542 1.00 88.43  ? 149 LYS C HZ2  1 
ATOM   2198 H  HZ3  . LYS A 1 144 ? -26.679 -7.485  -29.084 1.00 88.43  ? 149 LYS C HZ3  1 
ATOM   2199 N  N    . PRO A 1 145 ? -28.759 -4.459  -23.928 1.00 53.12  ? 150 PRO C N    1 
ATOM   2200 C  CA   . PRO A 1 145 ? -29.441 -4.475  -22.648 1.00 49.17  ? 150 PRO C CA   1 
ATOM   2201 C  C    . PRO A 1 145 ? -28.635 -5.117  -21.544 1.00 55.54  ? 150 PRO C C    1 
ATOM   2202 O  O    . PRO A 1 145 ? -27.663 -5.817  -21.860 1.00 59.71  ? 150 PRO C O    1 
ATOM   2203 C  CB   . PRO A 1 145 ? -30.673 -5.306  -22.954 1.00 49.25  ? 150 PRO C CB   1 
ATOM   2204 C  CG   . PRO A 1 145 ? -30.924 -5.051  -24.405 1.00 56.33  ? 150 PRO C CG   1 
ATOM   2205 C  CD   . PRO A 1 145 ? -29.531 -5.079  -24.985 1.00 55.89  ? 150 PRO C CD   1 
ATOM   2206 H  HA   . PRO A 1 145 ? -29.707 -3.555  -22.394 1.00 59.05  ? 150 PRO C HA   1 
ATOM   2207 H  HB2  . PRO A 1 145 ? -30.502 -6.261  -22.788 1.00 59.14  ? 150 PRO C HB2  1 
ATOM   2208 H  HB3  . PRO A 1 145 ? -31.440 -5.014  -22.404 1.00 59.14  ? 150 PRO C HB3  1 
ATOM   2209 H  HG2  . PRO A 1 145 ? -31.487 -5.750  -24.797 1.00 67.64  ? 150 PRO C HG2  1 
ATOM   2210 H  HG3  . PRO A 1 145 ? -31.348 -4.178  -24.542 1.00 67.64  ? 150 PRO C HG3  1 
ATOM   2211 H  HD2  . PRO A 1 145 ? -29.232 -5.999  -25.152 1.00 67.11  ? 150 PRO C HD2  1 
ATOM   2212 H  HD3  . PRO A 1 145 ? -29.485 -4.560  -25.817 1.00 67.11  ? 150 PRO C HD3  1 
ATOM   2213 N  N    . ALA A 1 146 ? -29.039 -4.920  -20.293 1.00 50.40  ? 151 ALA C N    1 
ATOM   2214 C  CA   . ALA A 1 146 ? -28.395 -5.523  -19.111 1.00 41.59  ? 151 ALA C CA   1 
ATOM   2215 C  C    . ALA A 1 146 ? -29.417 -6.407  -18.408 1.00 50.31  ? 151 ALA C C    1 
ATOM   2216 O  O    . ALA A 1 146 ? -30.597 -6.047  -18.452 1.00 45.83  ? 151 ALA C O    1 
ATOM   2217 C  CB   . ALA A 1 146 ? -27.891 -4.435  -18.212 1.00 47.99  ? 151 ALA C CB   1 
ATOM   2218 H  H    . ALA A 1 146 ? -29.740 -4.392  -20.089 1.00 60.52  ? 151 ALA C H    1 
ATOM   2219 H  HA   . ALA A 1 146 ? -27.634 -6.090  -19.403 1.00 49.95  ? 151 ALA C HA   1 
ATOM   2220 H  HB1  . ALA A 1 146 ? -27.503 -4.825  -17.412 1.00 57.63  ? 151 ALA C HB1  1 
ATOM   2221 H  HB2  . ALA A 1 146 ? -27.215 -3.914  -18.678 1.00 57.63  ? 151 ALA C HB2  1 
ATOM   2222 H  HB3  . ALA A 1 146 ? -28.628 -3.851  -17.962 1.00 57.63  ? 151 ALA C HB3  1 
ATOM   2223 N  N    . THR A 1 147 ? -28.992 -7.515  -17.808 1.00 40.76  ? 152 THR C N    1 
ATOM   2224 C  CA   . THR A 1 147 ? -29.883 -8.459  -17.108 1.00 44.99  ? 152 THR C CA   1 
ATOM   2225 C  C    . THR A 1 147 ? -29.522 -8.472  -15.645 1.00 48.39  ? 152 THR C C    1 
ATOM   2226 O  O    . THR A 1 147 ? -28.321 -8.462  -15.339 1.00 48.78  ? 152 THR C O    1 
ATOM   2227 C  CB   . THR A 1 147 ? -29.794 -9.844  -17.740 1.00 52.56  ? 152 THR C CB   1 
ATOM   2228 O  OG1  . THR A 1 147 ? -29.953 -9.611  -19.134 1.00 64.84  ? 152 THR C OG1  1 
ATOM   2229 C  CG2  . THR A 1 147 ? -30.886 -10.771 -17.242 1.00 51.92  ? 152 THR C CG2  1 
ATOM   2230 H  H    . THR A 1 147 ? -28.126 -7.766  -17.775 1.00 48.96  ? 152 THR C H    1 
ATOM   2231 H  HA   . THR A 1 147 ? -30.803 -8.144  -17.196 1.00 54.03  ? 152 THR C HA   1 
ATOM   2232 H  HB   . THR A 1 147 ? -28.908 -10.240 -17.565 1.00 63.12  ? 152 THR C HB   1 
ATOM   2233 H  HG1  . THR A 1 147 ? -30.707 -9.205  -19.264 1.00 77.86  ? 152 THR C HG1  1 
ATOM   2234 H  HG21 . THR A 1 147 ? -30.849 -11.611 -17.729 1.00 62.35  ? 152 THR C HG21 1 
ATOM   2235 H  HG22 . THR A 1 147 ? -30.762 -10.940 -16.294 1.00 62.35  ? 152 THR C HG22 1 
ATOM   2236 H  HG23 . THR A 1 147 ? -31.752 -10.352 -17.384 1.00 62.35  ? 152 THR C HG23 1 
ATOM   2237 N  N    . PHE A 1 148 ? -30.522 -8.493  -14.773 1.00 50.18  ? 153 PHE C N    1 
ATOM   2238 C  CA   . PHE A 1 148 ? -30.307 -8.435  -13.310 1.00 48.09  ? 153 PHE C CA   1 
ATOM   2239 C  C    . PHE A 1 148 ? -31.429 -9.141  -12.585 1.00 48.96  ? 153 PHE C C    1 
ATOM   2240 O  O    . PHE A 1 148 ? -32.499 -9.279  -13.182 1.00 47.25  ? 153 PHE C O    1 
ATOM   2241 C  CB   . PHE A 1 148 ? -30.343 -6.999  -12.780 1.00 46.33  ? 153 PHE C CB   1 
ATOM   2242 C  CG   . PHE A 1 148 ? -29.534 -5.919  -13.480 1.00 44.71  ? 153 PHE C CG   1 
ATOM   2243 C  CD1  . PHE A 1 148 ? -28.264 -5.586  -13.032 1.00 51.51  ? 153 PHE C CD1  1 
ATOM   2244 C  CD2  . PHE A 1 148 ? -30.072 -5.188  -14.530 1.00 49.20  ? 153 PHE C CD2  1 
ATOM   2245 C  CE1  . PHE A 1 148 ? -27.537 -4.583  -13.648 1.00 52.95  ? 153 PHE C CE1  1 
ATOM   2246 C  CE2  . PHE A 1 148 ? -29.341 -4.183  -15.138 1.00 43.07  ? 153 PHE C CE2  1 
ATOM   2247 C  CZ   . PHE A 1 148 ? -28.077 -3.882  -14.697 1.00 46.28  ? 153 PHE C CZ   1 
ATOM   2248 H  H    . PHE A 1 148 ? -31.381 -8.530  -15.043 1.00 60.25  ? 153 PHE C H    1 
ATOM   2249 H  HA   . PHE A 1 148 ? -29.442 -8.859  -13.076 1.00 57.75  ? 153 PHE C HA   1 
ATOM   2250 H  HB2  . PHE A 1 148 ? -31.282 -6.712  -12.770 1.00 55.64  ? 153 PHE C HB2  1 
ATOM   2251 H  HB3  . PHE A 1 148 ? -30.057 -7.025  -11.840 1.00 55.64  ? 153 PHE C HB3  1 
ATOM   2252 H  HD1  . PHE A 1 148 ? -27.888 -6.061  -12.309 1.00 61.86  ? 153 PHE C HD1  1 
ATOM   2253 H  HD2  . PHE A 1 148 ? -30.939 -5.392  -14.843 1.00 59.08  ? 153 PHE C HD2  1 
ATOM   2254 H  HE1  . PHE A 1 148 ? -26.670 -4.375  -13.342 1.00 63.58  ? 153 PHE C HE1  1 
ATOM   2255 H  HE2  . PHE A 1 148 ? -29.709 -3.708  -15.865 1.00 51.73  ? 153 PHE C HE2  1 
ATOM   2256 H  HZ   . PHE A 1 148 ? -27.579 -3.200  -15.117 1.00 55.59  ? 153 PHE C HZ   1 
ATOM   2257 N  N    . GLN A 1 149 ? -31.200 -9.568  -11.343 1.00 50.51  ? 154 GLN C N    1 
ATOM   2258 C  CA   . GLN A 1 149 ? -32.269 -10.126 -10.480 1.00 43.23  ? 154 GLN C CA   1 
ATOM   2259 C  C    . GLN A 1 149 ? -32.820 -8.951  -9.654  1.00 50.63  ? 154 GLN C C    1 
ATOM   2260 O  O    . GLN A 1 149 ? -31.994 -8.178  -9.139  1.00 45.49  ? 154 GLN C O    1 
ATOM   2261 C  CB   . GLN A 1 149 ? -31.758 -11.264 -9.601  1.00 53.86  ? 154 GLN C CB   1 
ATOM   2262 C  CG   . GLN A 1 149 ? -32.823 -12.305 -9.268  1.00 59.08  ? 154 GLN C CG   1 
ATOM   2263 C  CD   . GLN A 1 149 ? -32.438 -13.225 -8.133  1.00 61.20  ? 154 GLN C CD   1 
ATOM   2264 O  OE1  . GLN A 1 149 ? -31.261 -13.522 -7.907  1.00 68.71  ? 154 GLN C OE1  1 
ATOM   2265 N  NE2  . GLN A 1 149 ? -33.441 -13.695 -7.408  1.00 64.33  ? 154 GLN C NE2  1 
ATOM   2266 H  H    . GLN A 1 149 ? -30.378 -9.522  -10.975 1.00 60.66  ? 154 GLN C H    1 
ATOM   2267 H  HA   . GLN A 1 149 ? -32.995 -10.476 -11.054 1.00 51.92  ? 154 GLN C HA   1 
ATOM   2268 H  HB2  . GLN A 1 149 ? -31.013 -11.706 -10.058 1.00 64.67  ? 154 GLN C HB2  1 
ATOM   2269 H  HB3  . GLN A 1 149 ? -31.414 -10.883 -8.767  1.00 64.67  ? 154 GLN C HB3  1 
ATOM   2270 H  HG2  . GLN A 1 149 ? -33.656 -11.847 -9.026  1.00 70.94  ? 154 GLN C HG2  1 
ATOM   2271 H  HG3  . GLN A 1 149 ? -33.005 -12.848 -10.065 1.00 70.94  ? 154 GLN C HG3  1 
ATOM   2272 H  HE21 . GLN A 1 149 ? -34.223 -13.857 -7.794  1.00 77.24  ? 154 GLN C HE21 1 
ATOM   2273 H  HE22 . GLN A 1 149 ? -33.332 -13.842 -6.540  1.00 77.24  ? 154 GLN C HE22 1 
ATOM   2274 N  N    . VAL A 1 150 ? -34.139 -8.837  -9.505  1.00 38.97  ? 155 VAL C N    1 
ATOM   2275 C  CA   . VAL A 1 150 ? -34.784 -7.671  -8.830  1.00 43.34  ? 155 VAL C CA   1 
ATOM   2276 C  C    . VAL A 1 150 ? -34.283 -7.522  -7.385  1.00 55.73  ? 155 VAL C C    1 
ATOM   2277 O  O    . VAL A 1 150 ? -34.239 -6.383  -6.914  1.00 43.30  ? 155 VAL C O    1 
ATOM   2278 C  CB   . VAL A 1 150 ? -36.314 -7.839  -8.909  1.00 39.95  ? 155 VAL C CB   1 
ATOM   2279 C  CG1  . VAL A 1 150 ? -37.066 -6.963  -7.914  1.00 48.15  ? 155 VAL C CG1  1 
ATOM   2280 C  CG2  . VAL A 1 150 ? -36.831 -7.584  -10.318 1.00 46.92  ? 155 VAL C CG2  1 
ATOM   2281 H  H    . VAL A 1 150 ? -34.703 -9.471  -9.811  1.00 46.80  ? 155 VAL C H    1 
ATOM   2282 H  HA   . VAL A 1 150 ? -34.540 -6.864  -9.322  1.00 52.06  ? 155 VAL C HA   1 
ATOM   2283 H  HB   . VAL A 1 150 ? -36.511 -8.777  -8.684  1.00 47.99  ? 155 VAL C HB   1 
ATOM   2284 H  HG11 . VAL A 1 150 ? -38.006 -6.929  -8.160  1.00 57.83  ? 155 VAL C HG11 1 
ATOM   2285 H  HG12 . VAL A 1 150 ? -36.983 -7.335  -7.019  1.00 57.83  ? 155 VAL C HG12 1 
ATOM   2286 H  HG13 . VAL A 1 150 ? -36.698 -6.062  -7.927  1.00 57.83  ? 155 VAL C HG13 1 
ATOM   2287 H  HG21 . VAL A 1 150 ? -37.802 -7.565  -10.310 1.00 56.35  ? 155 VAL C HG21 1 
ATOM   2288 H  HG22 . VAL A 1 150 ? -36.493 -6.729  -10.636 1.00 56.35  ? 155 VAL C HG22 1 
ATOM   2289 H  HG23 . VAL A 1 150 ? -36.526 -8.292  -10.910 1.00 56.35  ? 155 VAL C HG23 1 
ATOM   2290 N  N    . SER A 1 151 ? -33.911 -8.612  -6.718  1.00 49.70  ? 156 SER C N    1 
ATOM   2291 C  CA   . SER A 1 151 ? -33.502 -8.602  -5.289  1.00 53.74  ? 156 SER C CA   1 
ATOM   2292 C  C    . SER A 1 151 ? -32.036 -8.200  -5.111  1.00 54.56  ? 156 SER C C    1 
ATOM   2293 O  O    . SER A 1 151 ? -31.693 -7.805  -3.989  1.00 60.23  ? 156 SER C O    1 
ATOM   2294 C  CB   . SER A 1 151 ? -33.739 -9.957  -4.694  1.00 51.45  ? 156 SER C CB   1 
ATOM   2295 O  OG   . SER A 1 151 ? -33.072 -10.959 -5.446  1.00 60.60  ? 156 SER C OG   1 
ATOM   2296 H  H    . SER A 1 151 ? -33.900 -9.423  -7.112  1.00 59.68  ? 156 SER C H    1 
ATOM   2297 H  HA   . SER A 1 151 ? -34.066 -7.946  -4.807  1.00 64.53  ? 156 SER C HA   1 
ATOM   2298 H  HB2  . SER A 1 151 ? -33.412 -9.968  -3.775  1.00 61.78  ? 156 SER C HB2  1 
ATOM   2299 H  HB3  . SER A 1 151 ? -34.697 -10.141 -4.682  1.00 61.78  ? 156 SER C HB3  1 
ATOM   2300 H  HG   . SER A 1 151 ? -33.654 -11.417 -5.856  1.00 72.77  ? 156 SER C HG   1 
ATOM   2301 N  N    . GLN A 1 152 ? -31.225 -8.256  -6.162  1.00 55.12  ? 157 GLN C N    1 
ATOM   2302 C  CA   . GLN A 1 152 ? -29.767 -8.005  -6.059  1.00 51.66  ? 157 GLN C CA   1 
ATOM   2303 C  C    . GLN A 1 152 ? -29.357 -6.593  -6.511  1.00 56.28  ? 157 GLN C C    1 
ATOM   2304 O  O    . GLN A 1 152 ? -28.144 -6.345  -6.571  1.00 57.37  ? 157 GLN C O    1 
ATOM   2305 C  CB   . GLN A 1 152 ? -29.121 -9.073  -6.932  1.00 56.49  ? 157 GLN C CB   1 
ATOM   2306 C  CG   . GLN A 1 152 ? -29.509 -10.501 -6.566  1.00 58.48  ? 157 GLN C CG   1 
ATOM   2307 C  CD   . GLN A 1 152 ? -29.282 -10.822 -5.107  1.00 72.54  ? 157 GLN C CD   1 
ATOM   2308 O  OE1  . GLN A 1 152 ? -30.224 -11.040 -4.339  1.00 74.97  ? 157 GLN C OE1  1 
ATOM   2309 N  NE2  . GLN A 1 152 ? -28.020 -10.836 -4.707  1.00 77.23  ? 157 GLN C NE2  1 
ATOM   2310 H  H    . GLN A 1 152 ? -31.535 -8.455  -6.986  1.00 66.18  ? 157 GLN C H    1 
ATOM   2311 H  HA   . GLN A 1 152 ? -29.483 -8.131  -5.123  1.00 62.04  ? 157 GLN C HA   1 
ATOM   2312 H  HB2  . GLN A 1 152 ? -29.375 -8.907  -7.863  1.00 67.83  ? 157 GLN C HB2  1 
ATOM   2313 H  HB3  . GLN A 1 152 ? -28.148 -8.985  -6.868  1.00 67.83  ? 157 GLN C HB3  1 
ATOM   2314 H  HG2  . GLN A 1 152 ? -30.455 -10.647 -6.779  1.00 70.23  ? 157 GLN C HG2  1 
ATOM   2315 H  HG3  . GLN A 1 152 ? -28.983 -11.125 -7.108  1.00 70.23  ? 157 GLN C HG3  1 
ATOM   2316 H  HE21 . GLN A 1 152 ? -27.368 -10.767 -5.304  1.00 92.73  ? 157 GLN C HE21 1 
ATOM   2317 H  HE22 . GLN A 1 152 ? -27.831 -10.912 -3.845  1.00 92.73  ? 157 GLN C HE22 1 
ATOM   2318 N  N    . VAL A 1 153 ? -30.303 -5.704  -6.796  1.00 48.29  ? 158 VAL C N    1 
ATOM   2319 C  CA   . VAL A 1 153 ? -29.993 -4.329  -7.293  1.00 41.71  ? 158 VAL C CA   1 
ATOM   2320 C  C    . VAL A 1 153 ? -30.121 -3.364  -6.106  1.00 41.37  ? 158 VAL C C    1 
ATOM   2321 O  O    . VAL A 1 153 ? -30.531 -3.815  -5.033  1.00 40.32  ? 158 VAL C O    1 
ATOM   2322 C  CB   . VAL A 1 153 ? -30.862 -3.887  -8.493  1.00 39.86  ? 158 VAL C CB   1 
ATOM   2323 C  CG1  . VAL A 1 153 ? -30.505 -4.650  -9.757  1.00 43.49  ? 158 VAL C CG1  1 
ATOM   2324 C  CG2  . VAL A 1 153 ? -32.356 -3.974  -8.220  1.00 33.83  ? 158 VAL C CG2  1 
ATOM   2325 H  H    . VAL A 1 153 ? -31.177 -5.901  -6.695  1.00 57.99  ? 158 VAL C H    1 
ATOM   2326 H  HA   . VAL A 1 153 ? -29.065 -4.313  -7.588  1.00 50.09  ? 158 VAL C HA   1 
ATOM   2327 H  HB   . VAL A 1 153 ? -30.660 -2.939  -8.661  1.00 47.88  ? 158 VAL C HB   1 
ATOM   2328 H  HG11 . VAL A 1 153 ? -30.975 -4.263  -10.514 1.00 52.23  ? 158 VAL C HG11 1 
ATOM   2329 H  HG12 . VAL A 1 153 ? -29.546 -4.594  -9.909  1.00 52.23  ? 158 VAL C HG12 1 
ATOM   2330 H  HG13 . VAL A 1 153 ? -30.763 -5.582  -9.658  1.00 52.23  ? 158 VAL C HG13 1 
ATOM   2331 H  HG21 . VAL A 1 153 ? -32.843 -3.585  -8.964  1.00 40.64  ? 158 VAL C HG21 1 
ATOM   2332 H  HG22 . VAL A 1 153 ? -32.609 -4.904  -8.121  1.00 40.64  ? 158 VAL C HG22 1 
ATOM   2333 H  HG23 . VAL A 1 153 ? -32.569 -3.489  -7.405  1.00 40.64  ? 158 VAL C HG23 1 
ATOM   2334 N  N    . ILE A 1 154 ? -29.785 -2.094  -6.311  1.00 41.31  ? 159 ILE C N    1 
ATOM   2335 C  CA   . ILE A 1 154 ? -29.899 -1.063  -5.245  1.00 40.07  ? 159 ILE C CA   1 
ATOM   2336 C  C    . ILE A 1 154 ? -31.369 -0.992  -4.795  1.00 36.92  ? 159 ILE C C    1 
ATOM   2337 O  O    . ILE A 1 154 ? -32.260 -1.196  -5.631  1.00 37.02  ? 159 ILE C O    1 
ATOM   2338 C  CB   . ILE A 1 154 ? -29.354 0.309   -5.689  1.00 43.42  ? 159 ILE C CB   1 
ATOM   2339 C  CG1  . ILE A 1 154 ? -30.072 0.894   -6.912  1.00 34.27  ? 159 ILE C CG1  1 
ATOM   2340 C  CG2  . ILE A 1 154 ? -27.842 0.240   -5.903  1.00 37.24  ? 159 ILE C CG2  1 
ATOM   2341 C  CD1  . ILE A 1 154 ? -29.886 2.391   -7.056  1.00 34.68  ? 159 ILE C CD1  1 
ATOM   2342 H  H    . ILE A 1 154 ? -29.471 -1.810  -7.107  1.00 49.62  ? 159 ILE C H    1 
ATOM   2343 H  HA   . ILE A 1 154 ? -29.358 -1.367  -4.495  1.00 48.13  ? 159 ILE C HA   1 
ATOM   2344 H  HB   . ILE A 1 154 ? -29.511 0.928   -4.948  1.00 52.15  ? 159 ILE C HB   1 
ATOM   2345 H  HG12 . ILE A 1 154 ? -29.735 0.457   -7.717  1.00 41.17  ? 159 ILE C HG12 1 
ATOM   2346 H  HG13 . ILE A 1 154 ? -31.029 0.705   -6.847  1.00 41.17  ? 159 ILE C HG13 1 
ATOM   2347 H  HG21 . ILE A 1 154 ? -27.433 1.066   -5.595  1.00 44.73  ? 159 ILE C HG21 1 
ATOM   2348 H  HG22 . ILE A 1 154 ? -27.475 -0.508  -5.403  1.00 44.73  ? 159 ILE C HG22 1 
ATOM   2349 H  HG23 . ILE A 1 154 ? -27.652 0.120   -6.848  1.00 44.73  ? 159 ILE C HG23 1 
ATOM   2350 H  HD11 . ILE A 1 154 ? -30.515 2.740   -7.717  1.00 41.65  ? 159 ILE C HD11 1 
ATOM   2351 H  HD12 . ILE A 1 154 ? -30.051 2.818   -6.194  1.00 41.65  ? 159 ILE C HD12 1 
ATOM   2352 H  HD13 . ILE A 1 154 ? -28.974 2.584   -7.343  1.00 41.65  ? 159 ILE C HD13 1 
ATOM   2353 N  N    . PRO A 1 155 ? -31.651 -0.723  -3.508  1.00 38.85  ? 160 PRO C N    1 
ATOM   2354 C  CA   . PRO A 1 155 ? -33.024 -0.704  -3.028  1.00 33.81  ? 160 PRO C CA   1 
ATOM   2355 C  C    . PRO A 1 155 ? -34.019 0.102   -3.859  1.00 33.53  ? 160 PRO C C    1 
ATOM   2356 O  O    . PRO A 1 155 ? -35.129 -0.386  -4.058  1.00 33.36  ? 160 PRO C O    1 
ATOM   2357 C  CB   . PRO A 1 155 ? -32.830 -0.112  -1.637  1.00 36.77  ? 160 PRO C CB   1 
ATOM   2358 C  CG   . PRO A 1 155 ? -31.480 -0.595  -1.213  1.00 34.94  ? 160 PRO C CG   1 
ATOM   2359 C  CD   . PRO A 1 155 ? -30.672 -0.446  -2.472  1.00 32.90  ? 160 PRO C CD   1 
ATOM   2360 H  HA   . PRO A 1 155 ? -33.343 -1.637  -2.945  1.00 40.62  ? 160 PRO C HA   1 
ATOM   2361 H  HB2  . PRO A 1 155 ? -32.856 0.871   -1.669  1.00 44.17  ? 160 PRO C HB2  1 
ATOM   2362 H  HB3  . PRO A 1 155 ? -33.528 -0.430  -1.019  1.00 44.17  ? 160 PRO C HB3  1 
ATOM   2363 H  HG2  . PRO A 1 155 ? -31.115 -0.042  -0.492  1.00 41.97  ? 160 PRO C HG2  1 
ATOM   2364 H  HG3  . PRO A 1 155 ? -31.511 -1.530  -0.923  1.00 41.97  ? 160 PRO C HG3  1 
ATOM   2365 H  HD2  . PRO A 1 155 ? -30.311 0.462   -2.558  1.00 39.53  ? 160 PRO C HD2  1 
ATOM   2366 H  HD3  . PRO A 1 155 ? -29.935 -1.094  -2.492  1.00 39.53  ? 160 PRO C HD3  1 
ATOM   2367 N  N    . GLY A 1 156 ? -33.632 1.273   -4.355  1.00 29.35  ? 161 GLY C N    1 
ATOM   2368 C  CA   . GLY A 1 156 ? -34.513 2.134   -5.169  1.00 33.29  ? 161 GLY C CA   1 
ATOM   2369 C  C    . GLY A 1 156 ? -35.052 1.416   -6.387  1.00 30.75  ? 161 GLY C C    1 
ATOM   2370 O  O    . GLY A 1 156 ? -36.245 1.578   -6.671  1.00 38.76  ? 161 GLY C O    1 
ATOM   2371 H  H    . GLY A 1 156 ? -32.798 1.588   -4.214  1.00 35.27  ? 161 GLY C H    1 
ATOM   2372 H  HA2  . GLY A 1 156 ? -35.265 2.442   -4.610  1.00 39.99  ? 161 GLY C HA2  1 
ATOM   2373 H  HA3  . GLY A 1 156 ? -34.005 2.929   -5.457  1.00 39.99  ? 161 GLY C HA3  1 
ATOM   2374 N  N    . TRP A 1 157 ? -34.218 0.634   -7.066  1.00 38.53  ? 162 TRP C N    1 
ATOM   2375 C  CA   . TRP A 1 157 ? -34.617 -0.155  -8.257  1.00 37.23  ? 162 TRP C CA   1 
ATOM   2376 C  C    . TRP A 1 157 ? -35.575 -1.269  -7.856  1.00 38.17  ? 162 TRP C C    1 
ATOM   2377 O  O    . TRP A 1 157 ? -36.579 -1.415  -8.534  1.00 31.90  ? 162 TRP C O    1 
ATOM   2378 C  CB   . TRP A 1 157 ? -33.376 -0.732  -8.939  1.00 36.37  ? 162 TRP C CB   1 
ATOM   2379 C  CG   . TRP A 1 157 ? -32.641 0.214   -9.846  1.00 35.99  ? 162 TRP C CG   1 
ATOM   2380 C  CD1  . TRP A 1 157 ? -32.356 1.527   -9.630  1.00 40.52  ? 162 TRP C CD1  1 
ATOM   2381 C  CD2  . TRP A 1 157 ? -32.078 -0.115  -11.130 1.00 37.19  ? 162 TRP C CD2  1 
ATOM   2382 N  NE1  . TRP A 1 157 ? -31.664 2.039   -10.691 1.00 36.89  ? 162 TRP C NE1  1 
ATOM   2383 C  CE2  . TRP A 1 157 ? -31.478 1.059   -11.627 1.00 33.45  ? 162 TRP C CE2  1 
ATOM   2384 C  CE3  . TRP A 1 157 ? -32.029 -1.279  -11.902 1.00 41.34  ? 162 TRP C CE3  1 
ATOM   2385 C  CZ2  . TRP A 1 157 ? -30.838 1.100   -12.860 1.00 38.81  ? 162 TRP C CZ2  1 
ATOM   2386 C  CZ3  . TRP A 1 157 ? -31.395 -1.237  -13.121 1.00 44.86  ? 162 TRP C CZ3  1 
ATOM   2387 C  CH2  . TRP A 1 157 ? -30.808 -0.064  -13.590 1.00 43.93  ? 162 TRP C CH2  1 
ATOM   2388 H  H    . TRP A 1 157 ? -33.356 0.543   -6.817  1.00 46.28  ? 162 TRP C H    1 
ATOM   2389 H  HA   . TRP A 1 157 ? -35.077 0.450   -8.899  1.00 44.72  ? 162 TRP C HA   1 
ATOM   2390 H  HB2  . TRP A 1 157 ? -32.758 -1.045  -8.244  1.00 43.69  ? 162 TRP C HB2  1 
ATOM   2391 H  HB3  . TRP A 1 157 ? -33.649 -1.518  -9.458  1.00 43.69  ? 162 TRP C HB3  1 
ATOM   2392 H  HD1  . TRP A 1 157 ? -32.600 2.024   -8.864  1.00 48.67  ? 162 TRP C HD1  1 
ATOM   2393 H  HE1  . TRP A 1 157 ? -31.389 2.855   -10.759 1.00 44.31  ? 162 TRP C HE1  1 
ATOM   2394 H  HE3  . TRP A 1 157 ? -32.424 -2.075  -11.590 1.00 49.66  ? 162 TRP C HE3  1 
ATOM   2395 H  HZ2  . TRP A 1 157 ? -30.439 1.890   -13.179 1.00 46.61  ? 162 TRP C HZ2  1 
ATOM   2396 H  HZ3  . TRP A 1 157 ? -31.354 -2.017  -13.651 1.00 53.87  ? 162 TRP C HZ3  1 
ATOM   2397 H  HH2  . TRP A 1 157 ? -30.382 -0.069  -14.422 1.00 52.75  ? 162 TRP C HH2  1 
ATOM   2398 N  N    . THR A 1 158 ? -35.273 -2.013  -6.797  1.00 38.46  ? 163 THR C N    1 
ATOM   2399 C  CA   . THR A 1 158 ? -36.118 -3.106  -6.283  1.00 33.63  ? 163 THR C CA   1 
ATOM   2400 C  C    . THR A 1 158 ? -37.521 -2.588  -6.055  1.00 39.02  ? 163 THR C C    1 
ATOM   2401 O  O    . THR A 1 158 ? -38.467 -3.271  -6.450  1.00 37.16  ? 163 THR C O    1 
ATOM   2402 C  CB   . THR A 1 158 ? -35.518 -3.676  -4.996  1.00 36.53  ? 163 THR C CB   1 
ATOM   2403 O  OG1  . THR A 1 158 ? -34.170 -4.033  -5.276  1.00 39.73  ? 163 THR C OG1  1 
ATOM   2404 C  CG2  . THR A 1 158 ? -36.276 -4.895  -4.508  1.00 43.73  ? 163 THR C CG2  1 
ATOM   2405 H  H    . THR A 1 158 ? -34.523 -1.900  -6.308  1.00 46.20  ? 163 THR C H    1 
ATOM   2406 H  HA   . THR A 1 158 ? -36.149 -3.820  -6.957  1.00 40.40  ? 163 THR C HA   1 
ATOM   2407 H  HB   . THR A 1 158 ? -35.532 -2.985  -4.292  1.00 43.88  ? 163 THR C HB   1 
ATOM   2408 H  HG1  . THR A 1 158 ? -34.142 -4.463  -6.022  1.00 47.72  ? 163 THR C HG1  1 
ATOM   2409 H  HG21 . THR A 1 158 ? -35.676 -5.470  -4.005  1.00 52.52  ? 163 THR C HG21 1 
ATOM   2410 H  HG22 . THR A 1 158 ? -37.012 -4.613  -3.937  1.00 52.52  ? 163 THR C HG22 1 
ATOM   2411 H  HG23 . THR A 1 158 ? -36.629 -5.383  -5.271  1.00 52.52  ? 163 THR C HG23 1 
ATOM   2412 N  N    . GLU A 1 159 ? -37.659 -1.403  -5.477  1.00 38.46  ? 164 GLU C N    1 
ATOM   2413 C  CA   . GLU A 1 159 ? -38.988 -0.841  -5.147  1.00 34.14  ? 164 GLU C CA   1 
ATOM   2414 C  C    . GLU A 1 159 ? -39.714 -0.454  -6.444  1.00 46.89  ? 164 GLU C C    1 
ATOM   2415 O  O    . GLU A 1 159 ? -40.856 -0.864  -6.618  1.00 39.53  ? 164 GLU C O    1 
ATOM   2416 C  CB   . GLU A 1 159 ? -38.853 0.351   -4.208  1.00 40.08  ? 164 GLU C CB   1 
ATOM   2417 C  CG   . GLU A 1 159 ? -37.969 0.093   -2.990  1.00 46.61  ? 164 GLU C CG   1 
ATOM   2418 C  CD   . GLU A 1 159 ? -38.554 0.365   -1.619  1.00 64.85  ? 164 GLU C CD   1 
ATOM   2419 O  OE1  . GLU A 1 159 ? -39.555 1.092   -1.500  1.00 76.46  ? 164 GLU C OE1  1 
ATOM   2420 O  OE2  . GLU A 1 159 ? -37.980 -0.161  -0.647  1.00 66.19  ? 164 GLU C OE2  1 
ATOM   2421 H  H    . GLU A 1 159 ? -36.942 -0.888  -5.289  1.00 46.20  ? 164 GLU C H    1 
ATOM   2422 H  HA   . GLU A 1 159 ? -39.515 -1.542  -4.687  1.00 41.02  ? 164 GLU C HA   1 
ATOM   2423 H  HB2  . GLU A 1 159 ? -38.463 1.096   -4.711  1.00 48.14  ? 164 GLU C HB2  1 
ATOM   2424 H  HB3  . GLU A 1 159 ? -39.749 0.622   -3.927  1.00 48.14  ? 164 GLU C HB3  1 
ATOM   2425 H  HG2  . GLU A 1 159 ? -37.677 -0.843  -3.007  1.00 55.97  ? 164 GLU C HG2  1 
ATOM   2426 H  HG3  . GLU A 1 159 ? -37.165 0.643   -3.079  1.00 55.97  ? 164 GLU C HG3  1 
ATOM   2427 N  N    . ALA A 1 160 ? -39.050 0.246   -7.352  1.00 42.50  ? 165 ALA C N    1 
ATOM   2428 C  CA   . ALA A 1 160 ? -39.666 0.721   -8.610  1.00 38.99  ? 165 ALA C CA   1 
ATOM   2429 C  C    . ALA A 1 160 ? -40.042 -0.441  -9.529  1.00 37.16  ? 165 ALA C C    1 
ATOM   2430 O  O    . ALA A 1 160 ? -41.165 -0.427  -10.042 1.00 30.28  ? 165 ALA C O    1 
ATOM   2431 C  CB   . ALA A 1 160 ? -38.707 1.646   -9.295  1.00 28.08  ? 165 ALA C CB   1 
ATOM   2432 H  H    . ALA A 1 160 ? -38.179 0.465   -7.261  1.00 51.05  ? 165 ALA C H    1 
ATOM   2433 H  HA   . ALA A 1 160 ? -40.498 1.222   -8.382  1.00 46.83  ? 165 ALA C HA   1 
ATOM   2434 H  HB1  . ALA A 1 160 ? -39.024 1.838   -10.194 1.00 33.74  ? 165 ALA C HB1  1 
ATOM   2435 H  HB2  . ALA A 1 160 ? -38.638 2.475   -8.794  1.00 33.74  ? 165 ALA C HB2  1 
ATOM   2436 H  HB3  . ALA A 1 160 ? -37.831 1.227   -9.345  1.00 33.74  ? 165 ALA C HB3  1 
ATOM   2437 N  N    . LEU A 1 161 ? -39.147 -1.398  -9.731  1.00 29.95  ? 166 LEU C N    1 
ATOM   2438 C  CA   . LEU A 1 161 ? -39.357 -2.504  -10.698 1.00 32.66  ? 166 LEU C CA   1 
ATOM   2439 C  C    . LEU A 1 161 ? -40.649 -3.264  -10.383 1.00 32.76  ? 166 LEU C C    1 
ATOM   2440 O  O    . LEU A 1 161 ? -41.350 -3.590  -11.337 1.00 39.91  ? 166 LEU C O    1 
ATOM   2441 C  CB   . LEU A 1 161 ? -38.134 -3.413  -10.692 1.00 27.00  ? 166 LEU C CB   1 
ATOM   2442 C  CG   . LEU A 1 161 ? -36.918 -2.899  -11.464 1.00 32.40  ? 166 LEU C CG   1 
ATOM   2443 C  CD1  . LEU A 1 161 ? -35.642 -3.526  -10.948 1.00 35.24  ? 166 LEU C CD1  1 
ATOM   2444 C  CD2  . LEU A 1 161 ? -37.085 -3.166  -12.943 1.00 41.36  ? 166 LEU C CD2  1 
ATOM   2445 H  H    . LEU A 1 161 ? -38.373 -1.417  -9.271  1.00 35.98  ? 166 LEU C H    1 
ATOM   2446 H  HA   . LEU A 1 161 ? -39.451 -2.104  -11.599 1.00 39.23  ? 166 LEU C HA   1 
ATOM   2447 H  HB2  . LEU A 1 161 ? -37.869 -3.562  -9.755  1.00 32.44  ? 166 LEU C HB2  1 
ATOM   2448 H  HB3  . LEU A 1 161 ? -38.398 -4.283  -11.071 1.00 32.44  ? 166 LEU C HB3  1 
ATOM   2449 H  HG   . LEU A 1 161 ? -36.858 -1.919  -11.331 1.00 38.92  ? 166 LEU C HG   1 
ATOM   2450 H  HD11 . LEU A 1 161 ? -34.896 -2.921  -11.101 1.00 42.33  ? 166 LEU C HD11 1 
ATOM   2451 H  HD12 . LEU A 1 161 ? -35.726 -3.699  -9.995  1.00 42.33  ? 166 LEU C HD12 1 
ATOM   2452 H  HD13 . LEU A 1 161 ? -35.481 -4.364  -11.415 1.00 42.33  ? 166 LEU C HD13 1 
ATOM   2453 H  HD21 . LEU A 1 161 ? -36.263 -2.941  -13.409 1.00 49.68  ? 166 LEU C HD21 1 
ATOM   2454 H  HD22 . LEU A 1 161 ? -37.289 -4.107  -13.081 1.00 49.68  ? 166 LEU C HD22 1 
ATOM   2455 H  HD23 . LEU A 1 161 ? -37.814 -2.624  -13.291 1.00 49.68  ? 166 LEU C HD23 1 
ATOM   2456 N  N    . GLN A 1 162 ? -41.002 -3.426  -9.113  1.00 37.80  ? 167 GLN C N    1 
ATOM   2457 C  CA   . GLN A 1 162 ? -42.204 -4.195  -8.700  1.00 37.79  ? 167 GLN C CA   1 
ATOM   2458 C  C    . GLN A 1 162 ? -43.495 -3.435  -9.046  1.00 37.24  ? 167 GLN C C    1 
ATOM   2459 O  O    . GLN A 1 162 ? -44.559 -4.039  -8.915  1.00 37.53  ? 167 GLN C O    1 
ATOM   2460 C  CB   . GLN A 1 162 ? -42.064 -4.505  -7.212  1.00 39.92  ? 167 GLN C CB   1 
ATOM   2461 C  CG   . GLN A 1 162 ? -41.001 -5.541  -6.869  1.00 38.99  ? 167 GLN C CG   1 
ATOM   2462 C  CD   . GLN A 1 162 ? -40.914 -5.799  -5.381  1.00 47.58  ? 167 GLN C CD   1 
ATOM   2463 O  OE1  . GLN A 1 162 ? -41.812 -6.401  -4.785  1.00 42.01  ? 167 GLN C OE1  1 
ATOM   2464 N  NE2  . GLN A 1 162 ? -39.843 -5.335  -4.757  1.00 44.50  ? 167 GLN C NE2  1 
ATOM   2465 H  H    . GLN A 1 162 ? -40.513 -3.073  -8.442  1.00 45.40  ? 167 GLN C H    1 
ATOM   2466 H  HA   . GLN A 1 162 ? -42.204 -5.047  -9.195  1.00 45.40  ? 167 GLN C HA   1 
ATOM   2467 H  HB2  . GLN A 1 162 ? -41.852 -3.672  -6.742  1.00 47.94  ? 167 GLN C HB2  1 
ATOM   2468 H  HB3  . GLN A 1 162 ? -42.928 -4.821  -6.878  1.00 47.94  ? 167 GLN C HB3  1 
ATOM   2469 H  HG2  . GLN A 1 162 ? -41.211 -6.383  -7.326  1.00 46.84  ? 167 GLN C HG2  1 
ATOM   2470 H  HG3  . GLN A 1 162 ? -40.129 -5.234  -7.194  1.00 46.84  ? 167 GLN C HG3  1 
ATOM   2471 H  HE21 . GLN A 1 162 ? -39.212 -4.906  -5.212  1.00 53.44  ? 167 GLN C HE21 1 
ATOM   2472 H  HE22 . GLN A 1 162 ? -39.753 -5.459  -3.882  1.00 53.44  ? 167 GLN C HE22 1 
ATOM   2473 N  N    . LEU A 1 163 ? -43.406 -2.179  -9.470  1.00 35.63  ? 168 LEU C N    1 
ATOM   2474 C  CA   . LEU A 1 163 ? -44.571 -1.353  -9.874  1.00 37.42  ? 168 LEU C CA   1 
ATOM   2475 C  C    . LEU A 1 163 ? -44.559 -1.119  -11.390 1.00 34.61  ? 168 LEU C C    1 
ATOM   2476 O  O    . LEU A 1 163 ? -45.526 -0.533  -11.870 1.00 31.89  ? 168 LEU C O    1 
ATOM   2477 C  CB   . LEU A 1 163 ? -44.504 -0.010  -9.153  1.00 36.44  ? 168 LEU C CB   1 
ATOM   2478 C  CG   . LEU A 1 163 ? -44.061 -0.003  -7.690  1.00 39.77  ? 168 LEU C CG   1 
ATOM   2479 C  CD1  . LEU A 1 163 ? -43.876 1.427   -7.233  1.00 39.48  ? 168 LEU C CD1  1 
ATOM   2480 C  CD2  . LEU A 1 163 ? -45.054 -0.727  -6.817  1.00 40.86  ? 168 LEU C CD2  1 
ATOM   2481 H  H    . LEU A 1 163 ? -42.616 -1.748  -9.492  1.00 42.80  ? 168 LEU C H    1 
ATOM   2482 H  HA   . LEU A 1 163 ? -45.407 -1.818  -9.626  1.00 44.94  ? 168 LEU C HA   1 
ATOM   2483 H  HB2  . LEU A 1 163 ? -43.890 0.572   -9.658  1.00 43.77  ? 168 LEU C HB2  1 
ATOM   2484 H  HB3  . LEU A 1 163 ? -45.394 0.407   -9.205  1.00 43.77  ? 168 LEU C HB3  1 
ATOM   2485 H  HG   . LEU A 1 163 ? -43.189 -0.463  -7.622  1.00 47.77  ? 168 LEU C HG   1 
ATOM   2486 H  HD11 . LEU A 1 163 ? -43.900 1.466   -6.263  1.00 47.42  ? 168 LEU C HD11 1 
ATOM   2487 H  HD12 . LEU A 1 163 ? -43.018 1.759   -7.549  1.00 47.42  ? 168 LEU C HD12 1 
ATOM   2488 H  HD13 . LEU A 1 163 ? -44.588 1.979   -7.598  1.00 47.42  ? 168 LEU C HD13 1 
ATOM   2489 H  HD21 . LEU A 1 163 ? -44.939 -0.447  -5.894  1.00 49.08  ? 168 LEU C HD21 1 
ATOM   2490 H  HD22 . LEU A 1 163 ? -45.956 -0.516  -7.110  1.00 49.08  ? 168 LEU C HD22 1 
ATOM   2491 H  HD23 . LEU A 1 163 ? -44.907 -1.685  -6.886  1.00 49.08  ? 168 LEU C HD23 1 
ATOM   2492 N  N    . MET A 1 164 ? -43.536 -1.582  -12.101 1.00 31.57  ? 169 MET C N    1 
ATOM   2493 C  CA   . MET A 1 164 ? -43.356 -1.250  -13.538 1.00 36.93  ? 169 MET C CA   1 
ATOM   2494 C  C    . MET A 1 164 ? -43.891 -2.342  -14.471 1.00 31.49  ? 169 MET C C    1 
ATOM   2495 O  O    . MET A 1 164 ? -43.336 -3.442  -14.465 1.00 35.70  ? 169 MET C O    1 
ATOM   2496 C  CB   . MET A 1 164 ? -41.875 -1.036  -13.845 1.00 35.73  ? 169 MET C CB   1 
ATOM   2497 C  CG   . MET A 1 164 ? -41.439 0.406   -13.755 1.00 43.49  ? 169 MET C CG   1 
ATOM   2498 S  SD   . MET A 1 164 ? -39.697 0.621   -14.163 1.00 39.24  ? 169 MET C SD   1 
ATOM   2499 C  CE   . MET A 1 164 ? -39.846 1.010   -15.912 1.00 31.71  ? 169 MET C CE   1 
ATOM   2500 H  H    . MET A 1 164 ? -42.910 -2.117  -11.734 1.00 37.93  ? 169 MET C H    1 
ATOM   2501 H  HA   . MET A 1 164 ? -43.830 -0.405  -13.717 1.00 44.36  ? 169 MET C HA   1 
ATOM   2502 H  HB2  . MET A 1 164 ? -41.343 -1.569  -13.217 1.00 42.92  ? 169 MET C HB2  1 
ATOM   2503 H  HB3  . MET A 1 164 ? -41.691 -1.366  -14.751 1.00 42.92  ? 169 MET C HB3  1 
ATOM   2504 H  HG2  . MET A 1 164 ? -41.975 0.941   -14.372 1.00 52.23  ? 169 MET C HG2  1 
ATOM   2505 H  HG3  . MET A 1 164 ? -41.598 0.737   -12.849 1.00 52.23  ? 169 MET C HG3  1 
ATOM   2506 H  HE1  . MET A 1 164 ? -39.106 0.605   -16.401 1.00 38.09  ? 169 MET C HE1  1 
ATOM   2507 H  HE2  . MET A 1 164 ? -40.691 0.660   -16.252 1.00 38.09  ? 169 MET C HE2  1 
ATOM   2508 H  HE3  . MET A 1 164 ? -39.826 1.978   -16.033 1.00 38.09  ? 169 MET C HE3  1 
ATOM   2509 N  N    . PRO A 1 165 ? -44.941 -2.090  -15.278 1.00 33.08  ? 170 PRO C N    1 
ATOM   2510 C  CA   . PRO A 1 165 ? -45.363 -3.065  -16.270 1.00 31.63  ? 170 PRO C CA   1 
ATOM   2511 C  C    . PRO A 1 165 ? -44.245 -3.246  -17.291 1.00 31.91  ? 170 PRO C C    1 
ATOM   2512 O  O    . PRO A 1 165 ? -43.569 -2.277  -17.618 1.00 39.35  ? 170 PRO C O    1 
ATOM   2513 C  CB   . PRO A 1 165 ? -46.614 -2.440  -16.860 1.00 36.23  ? 170 PRO C CB   1 
ATOM   2514 C  CG   . PRO A 1 165 ? -47.082 -1.481  -15.808 1.00 36.85  ? 170 PRO C CG   1 
ATOM   2515 C  CD   . PRO A 1 165 ? -45.799 -0.928  -15.248 1.00 36.92  ? 170 PRO C CD   1 
ATOM   2516 H  HA   . PRO A 1 165 ? -45.583 -3.927  -15.833 1.00 38.00  ? 170 PRO C HA   1 
ATOM   2517 H  HB2  . PRO A 1 165 ? -46.406 -1.967  -17.699 1.00 43.52  ? 170 PRO C HB2  1 
ATOM   2518 H  HB3  . PRO A 1 165 ? -47.298 -3.126  -17.041 1.00 43.52  ? 170 PRO C HB3  1 
ATOM   2519 H  HG2  . PRO A 1 165 ? -47.630 -0.769  -16.198 1.00 44.26  ? 170 PRO C HG2  1 
ATOM   2520 H  HG3  . PRO A 1 165 ? -47.597 -1.942  -15.114 1.00 44.26  ? 170 PRO C HG3  1 
ATOM   2521 H  HD2  . PRO A 1 165 ? -45.444 -0.207  -15.809 1.00 44.35  ? 170 PRO C HD2  1 
ATOM   2522 H  HD3  . PRO A 1 165 ? -45.929 -0.599  -14.336 1.00 44.35  ? 170 PRO C HD3  1 
ATOM   2523 N  N    . ALA A 1 166 ? -44.015 -4.462  -17.768 1.00 37.23  ? 171 ALA C N    1 
ATOM   2524 C  CA   . ALA A 1 166 ? -42.998 -4.724  -18.813 1.00 38.88  ? 171 ALA C CA   1 
ATOM   2525 C  C    . ALA A 1 166 ? -43.330 -3.929  -20.079 1.00 32.81  ? 171 ALA C C    1 
ATOM   2526 O  O    . ALA A 1 166 ? -44.511 -3.889  -20.453 1.00 31.38  ? 171 ALA C O    1 
ATOM   2527 C  CB   . ALA A 1 166 ? -42.890 -6.193  -19.087 1.00 40.43  ? 171 ALA C CB   1 
ATOM   2528 H  H    . ALA A 1 166 ? -44.460 -5.194  -17.488 1.00 44.72  ? 171 ALA C H    1 
ATOM   2529 H  HA   . ALA A 1 166 ? -42.119 -4.399  -18.472 1.00 46.70  ? 171 ALA C HA   1 
ATOM   2530 H  HB1  . ALA A 1 166 ? -42.446 -6.334  -19.939 1.00 48.56  ? 171 ALA C HB1  1 
ATOM   2531 H  HB2  . ALA A 1 166 ? -42.374 -6.617  -18.381 1.00 48.56  ? 171 ALA C HB2  1 
ATOM   2532 H  HB3  . ALA A 1 166 ? -43.779 -6.586  -19.116 1.00 48.56  ? 171 ALA C HB3  1 
ATOM   2533 N  N    . GLY A 1 167 ? -42.322 -3.327  -20.708 1.00 27.34  ? 172 GLY C N    1 
ATOM   2534 C  CA   . GLY A 1 167 ? -42.496 -2.446  -21.878 1.00 33.36  ? 172 GLY C CA   1 
ATOM   2535 C  C    . GLY A 1 167 ? -42.490 -0.985  -21.471 1.00 35.26  ? 172 GLY C C    1 
ATOM   2536 O  O    . GLY A 1 167 ? -42.418 -0.153  -22.377 1.00 34.62  ? 172 GLY C O    1 
ATOM   2537 H  H    . GLY A 1 167 ? -41.474 -3.441  -20.431 1.00 32.85  ? 172 GLY C H    1 
ATOM   2538 H  HA2  . GLY A 1 167 ? -41.762 -2.611  -22.515 1.00 40.08  ? 172 GLY C HA2  1 
ATOM   2539 H  HA3  . GLY A 1 167 ? -43.344 -2.660  -22.329 1.00 40.08  ? 172 GLY C HA3  1 
ATOM   2540 N  N    . SER A 1 168 ? -42.538 -0.674  -20.173 1.00 35.34  ? 173 SER C N    1 
ATOM   2541 C  CA   . SER A 1 168 ? -42.631 0.717   -19.656 1.00 29.30  ? 173 SER C CA   1 
ATOM   2542 C  C    . SER A 1 168 ? -41.279 1.433   -19.612 1.00 30.05  ? 173 SER C C    1 
ATOM   2543 O  O    . SER A 1 168 ? -40.267 0.741   -19.500 1.00 31.50  ? 173 SER C O    1 
ATOM   2544 C  CB   . SER A 1 168 ? -43.225 0.755   -18.275 1.00 31.92  ? 173 SER C CB   1 
ATOM   2545 O  OG   . SER A 1 168 ? -44.525 0.204   -18.192 1.00 32.55  ? 173 SER C OG   1 
ATOM   2546 H  H    . SER A 1 168 ? -42.513 -1.311  -19.536 1.00 42.46  ? 173 SER C H    1 
ATOM   2547 H  HA   . SER A 1 168 ? -43.227 1.226   -20.260 1.00 35.20  ? 173 SER C HA   1 
ATOM   2548 H  HB2  . SER A 1 168 ? -42.635 0.273   -17.664 1.00 38.34  ? 173 SER C HB2  1 
ATOM   2549 H  HB3  . SER A 1 168 ? -43.259 1.684   -17.974 1.00 38.34  ? 173 SER C HB3  1 
ATOM   2550 H  HG   . SER A 1 168 ? -44.481 -0.626  -18.331 1.00 39.10  ? 173 SER C HG   1 
ATOM   2551 N  N    . THR A 1 169 ? -41.278 2.762   -19.689 1.00 29.32  ? 174 THR C N    1 
ATOM   2552 C  CA   . THR A 1 169 ? -40.079 3.605   -19.537 1.00 26.25  ? 174 THR C CA   1 
ATOM   2553 C  C    . THR A 1 169 ? -40.416 4.640   -18.487 1.00 30.83  ? 174 THR C C    1 
ATOM   2554 O  O    . THR A 1 169 ? -41.365 5.396   -18.701 1.00 29.17  ? 174 THR C O    1 
ATOM   2555 C  CB   . THR A 1 169 ? -39.632 4.233   -20.852 1.00 28.85  ? 174 THR C CB   1 
ATOM   2556 O  OG1  . THR A 1 169 ? -39.132 3.173   -21.654 1.00 36.78  ? 174 THR C OG1  1 
ATOM   2557 C  CG2  . THR A 1 169 ? -38.531 5.255   -20.639 1.00 32.31  ? 174 THR C CG2  1 
ATOM   2558 H  H    . THR A 1 169 ? -42.021 3.250   -19.830 1.00 35.23  ? 174 THR C H    1 
ATOM   2559 H  HA   . THR A 1 169 ? -39.349 3.049   -19.202 1.00 31.54  ? 174 THR C HA   1 
ATOM   2560 H  HB   . THR A 1 169 ? -40.403 4.654   -21.301 1.00 34.66  ? 174 THR C HB   1 
ATOM   2561 H  HG1  . THR A 1 169 ? -39.783 2.673   -21.921 1.00 44.18  ? 174 THR C HG1  1 
ATOM   2562 H  HG21 . THR A 1 169 ? -38.039 5.379   -21.467 1.00 38.82  ? 174 THR C HG21 1 
ATOM   2563 H  HG22 . THR A 1 169 ? -38.920 6.104   -20.365 1.00 38.82  ? 174 THR C HG22 1 
ATOM   2564 H  HG23 . THR A 1 169 ? -37.925 4.939   -19.947 1.00 38.82  ? 174 THR C HG23 1 
ATOM   2565 N  N    . TRP A 1 170 ? -39.688 4.651   -17.379 1.00 32.84  ? 175 TRP C N    1 
ATOM   2566 C  CA   . TRP A 1 170 ? -39.930 5.573   -16.251 1.00 27.40  ? 175 TRP C CA   1 
ATOM   2567 C  C    . TRP A 1 170 ? -38.669 6.337   -15.901 1.00 36.68  ? 175 TRP C C    1 
ATOM   2568 O  O    . TRP A 1 170 ? -37.594 5.850   -16.248 1.00 27.54  ? 175 TRP C O    1 
ATOM   2569 C  CB   . TRP A 1 170 ? -40.335 4.799   -14.996 1.00 30.36  ? 175 TRP C CB   1 
ATOM   2570 C  CG   . TRP A 1 170 ? -41.711 4.198   -14.937 1.00 31.44  ? 175 TRP C CG   1 
ATOM   2571 C  CD1  . TRP A 1 170 ? -42.583 3.915   -15.943 1.00 28.34  ? 175 TRP C CD1  1 
ATOM   2572 C  CD2  . TRP A 1 170 ? -42.345 3.749   -13.722 1.00 30.75  ? 175 TRP C CD2  1 
ATOM   2573 N  NE1  . TRP A 1 170 ? -43.713 3.339   -15.438 1.00 32.34  ? 175 TRP C NE1  1 
ATOM   2574 C  CE2  . TRP A 1 170 ? -43.598 3.222   -14.081 1.00 33.27  ? 175 TRP C CE2  1 
ATOM   2575 C  CE3  . TRP A 1 170 ? -41.973 3.749   -12.375 1.00 43.62  ? 175 TRP C CE3  1 
ATOM   2576 C  CZ2  . TRP A 1 170 ? -44.480 2.700   -13.140 1.00 39.25  ? 175 TRP C CZ2  1 
ATOM   2577 C  CZ3  . TRP A 1 170 ? -42.846 3.232   -11.445 1.00 36.66  ? 175 TRP C CZ3  1 
ATOM   2578 C  CH2  . TRP A 1 170 ? -44.078 2.709   -11.825 1.00 37.62  ? 175 TRP C CH2  1 
ATOM   2579 H  H    . TRP A 1 170 ? -39.001 4.078   -17.264 1.00 39.45  ? 175 TRP C H    1 
ATOM   2580 H  HA   . TRP A 1 170 ? -40.651 6.215   -16.485 1.00 32.93  ? 175 TRP C HA   1 
ATOM   2581 H  HB2  . TRP A 1 170 ? -39.681 4.078   -14.868 1.00 36.47  ? 175 TRP C HB2  1 
ATOM   2582 H  HB3  . TRP A 1 170 ? -40.228 5.397   -14.226 1.00 36.47  ? 175 TRP C HB3  1 
ATOM   2583 H  HD1  . TRP A 1 170 ? -42.453 4.086   -16.852 1.00 34.05  ? 175 TRP C HD1  1 
ATOM   2584 H  HE1  . TRP A 1 170 ? -44.394 3.091   -15.913 1.00 38.85  ? 175 TRP C HE1  1 
ATOM   2585 H  HE3  . TRP A 1 170 ? -41.141 4.101   -12.109 1.00 52.39  ? 175 TRP C HE3  1 
ATOM   2586 H  HZ2  . TRP A 1 170 ? -45.312 2.342   -13.397 1.00 47.15  ? 175 TRP C HZ2  1 
ATOM   2587 H  HZ3  . TRP A 1 170 ? -42.603 3.227   -10.534 1.00 44.04  ? 175 TRP C HZ3  1 
ATOM   2588 H  HH2  . TRP A 1 170 ? -44.654 2.362   -11.167 1.00 45.19  ? 175 TRP C HH2  1 
ATOM   2589 N  N    . GLU A 1 171 ? -38.804 7.493   -15.259 1.00 26.79  ? 176 GLU C N    1 
ATOM   2590 C  CA   . GLU A 1 171 ? -37.648 8.219   -14.696 1.00 27.86  ? 176 GLU C CA   1 
ATOM   2591 C  C    . GLU A 1 171 ? -37.813 8.133   -13.176 1.00 27.39  ? 176 GLU C C    1 
ATOM   2592 O  O    . GLU A 1 171 ? -38.919 8.428   -12.707 1.00 29.60  ? 176 GLU C O    1 
ATOM   2593 C  CB   . GLU A 1 171 ? -37.505 9.687   -15.067 1.00 27.98  ? 176 GLU C CB   1 
ATOM   2594 C  CG   . GLU A 1 171 ? -36.333 10.301  -14.314 1.00 35.13  ? 176 GLU C CG   1 
ATOM   2595 C  CD   . GLU A 1 171 ? -35.630 11.421  -15.037 1.00 39.90  ? 176 GLU C CD   1 
ATOM   2596 O  OE1  . GLU A 1 171 ? -35.689 12.537  -14.518 1.00 39.84  ? 176 GLU C OE1  1 
ATOM   2597 O  OE2  . GLU A 1 171 ? -35.009 11.173  -16.078 1.00 40.94  ? 176 GLU C OE2  1 
ATOM   2598 H  H    . GLU A 1 171 ? -39.612 7.875   -15.140 1.00 32.20  ? 176 GLU C H    1 
ATOM   2599 H  HA   . GLU A 1 171 ? -36.817 7.750   -14.949 1.00 33.48  ? 176 GLU C HA   1 
ATOM   2600 H  HB2  . GLU A 1 171 ? -37.368 9.765   -16.034 1.00 33.63  ? 176 GLU C HB2  1 
ATOM   2601 H  HB3  . GLU A 1 171 ? -38.334 10.159  -14.839 1.00 33.63  ? 176 GLU C HB3  1 
ATOM   2602 H  HG2  . GLU A 1 171 ? -36.650 10.636  -13.453 1.00 42.20  ? 176 GLU C HG2  1 
ATOM   2603 H  HG3  . GLU A 1 171 ? -35.677 9.597   -14.126 1.00 42.20  ? 176 GLU C HG3  1 
ATOM   2604 N  N    . ILE A 1 172 ? -36.768 7.745   -12.458 1.00 28.10  ? 177 ILE C N    1 
ATOM   2605 C  CA   . ILE A 1 172 ? -36.836 7.548   -10.981 1.00 29.42  ? 177 ILE C CA   1 
ATOM   2606 C  C    . ILE A 1 172 ? -35.840 8.477   -10.271 1.00 33.59  ? 177 ILE C C    1 
ATOM   2607 O  O    . ILE A 1 172 ? -34.765 8.714   -10.835 1.00 30.64  ? 177 ILE C O    1 
ATOM   2608 C  CB   . ILE A 1 172 ? -36.646 6.062   -10.621 1.00 27.52  ? 177 ILE C CB   1 
ATOM   2609 C  CG1  . ILE A 1 172 ? -35.306 5.498   -11.078 1.00 31.11  ? 177 ILE C CG1  1 
ATOM   2610 C  CG2  . ILE A 1 172 ? -37.812 5.241   -11.167 1.00 33.00  ? 177 ILE C CG2  1 
ATOM   2611 C  CD1  . ILE A 1 172 ? -34.821 4.331   -10.242 1.00 34.00  ? 177 ILE C CD1  1 
ATOM   2612 H  H    . ILE A 1 172 ? -35.966 7.589   -12.836 1.00 33.76  ? 177 ILE C H    1 
ATOM   2613 H  HA   . ILE A 1 172 ? -37.727 7.799   -10.684 1.00 35.35  ? 177 ILE C HA   1 
ATOM   2614 H  HB   . ILE A 1 172 ? -36.671 5.994   -9.646  1.00 33.06  ? 177 ILE C HB   1 
ATOM   2615 H  HG12 . ILE A 1 172 ? -35.390 5.205   -12.008 1.00 37.38  ? 177 ILE C HG12 1 
ATOM   2616 H  HG13 . ILE A 1 172 ? -34.632 6.207   -11.049 1.00 37.38  ? 177 ILE C HG13 1 
ATOM   2617 H  HG21 . ILE A 1 172 ? -37.869 4.397   -10.689 1.00 39.64  ? 177 ILE C HG21 1 
ATOM   2618 H  HG22 . ILE A 1 172 ? -38.641 5.736   -11.049 1.00 39.64  ? 177 ILE C HG22 1 
ATOM   2619 H  HG23 . ILE A 1 172 ? -37.673 5.068   -12.113 1.00 39.64  ? 177 ILE C HG23 1 
ATOM   2620 H  HD11 . ILE A 1 172 ? -33.866 4.198   -10.394 1.00 40.85  ? 177 ILE C HD11 1 
ATOM   2621 H  HD12 . ILE A 1 172 ? -34.979 4.516   -9.297  1.00 40.85  ? 177 ILE C HD12 1 
ATOM   2622 H  HD13 . ILE A 1 172 ? -35.306 3.524   -10.500 1.00 40.85  ? 177 ILE C HD13 1 
ATOM   2623 N  N    . TYR A 1 173 ? -36.212 8.988   -9.105  1.00 22.22  ? 178 TYR C N    1 
ATOM   2624 C  CA   . TYR A 1 173 ? -35.383 9.904   -8.279  1.00 27.69  ? 178 TYR C CA   1 
ATOM   2625 C  C    . TYR A 1 173 ? -35.145 9.153   -6.981  1.00 33.89  ? 178 TYR C C    1 
ATOM   2626 O  O    . TYR A 1 173 ? -36.109 8.986   -6.220  1.00 31.35  ? 178 TYR C O    1 
ATOM   2627 C  CB   . TYR A 1 173 ? -36.135 11.235  -8.208  1.00 27.48  ? 178 TYR C CB   1 
ATOM   2628 C  CG   . TYR A 1 173 ? -36.738 11.682  -9.530  1.00 26.47  ? 178 TYR C CG   1 
ATOM   2629 C  CD1  . TYR A 1 173 ? -38.010 11.279  -9.910  1.00 27.19  ? 178 TYR C CD1  1 
ATOM   2630 C  CD2  . TYR A 1 173 ? -36.030 12.500  -10.396 1.00 32.52  ? 178 TYR C CD2  1 
ATOM   2631 C  CE1  . TYR A 1 173 ? -38.563 11.671  -11.114 1.00 33.02  ? 178 TYR C CE1  1 
ATOM   2632 C  CE2  . TYR A 1 173 ? -36.573 12.908  -11.600 1.00 31.95  ? 178 TYR C CE2  1 
ATOM   2633 C  CZ   . TYR A 1 173 ? -37.844 12.496  -11.957 1.00 34.90  ? 178 TYR C CZ   1 
ATOM   2634 O  OH   . TYR A 1 173 ? -38.388 12.871  -13.145 1.00 32.21  ? 178 TYR C OH   1 
ATOM   2635 H  H    . TYR A 1 173 ? -37.011 8.786   -8.741  1.00 26.71  ? 178 TYR C H    1 
ATOM   2636 H  HA   . TYR A 1 173 ? -34.512 10.053  -8.729  1.00 33.27  ? 178 TYR C HA   1 
ATOM   2637 H  HB2  . TYR A 1 173 ? -36.856 11.153  -7.546  1.00 33.01  ? 178 TYR C HB2  1 
ATOM   2638 H  HB3  . TYR A 1 173 ? -35.513 11.928  -7.894  1.00 33.01  ? 178 TYR C HB3  1 
ATOM   2639 H  HD1  . TYR A 1 173 ? -38.507 10.722  -9.337  1.00 32.68  ? 178 TYR C HD1  1 
ATOM   2640 H  HD2  . TYR A 1 173 ? -35.163 12.787  -10.158 1.00 39.06  ? 178 TYR C HD2  1 
ATOM   2641 H  HE1  . TYR A 1 173 ? -39.429 11.388  -11.354 1.00 39.67  ? 178 TYR C HE1  1 
ATOM   2642 H  HE2  . TYR A 1 173 ? -36.079 13.464  -12.175 1.00 38.39  ? 178 TYR C HE2  1 
ATOM   2643 H  HH   . TYR A 1 173 ? -37.820 12.750  -13.774 1.00 38.69  ? 178 TYR C HH   1 
ATOM   2644 N  N    . VAL A 1 174 ? -33.922 8.697   -6.736  1.00 31.80  ? 179 VAL C N    1 
ATOM   2645 C  CA   . VAL A 1 174 ? -33.626 7.779   -5.600  1.00 33.65  ? 179 VAL C CA   1 
ATOM   2646 C  C    . VAL A 1 174 ? -32.914 8.486   -4.442  1.00 32.06  ? 179 VAL C C    1 
ATOM   2647 O  O    . VAL A 1 174 ? -31.798 8.974   -4.651  1.00 31.97  ? 179 VAL C O    1 
ATOM   2648 C  CB   . VAL A 1 174 ? -32.776 6.607   -6.124  1.00 29.83  ? 179 VAL C CB   1 
ATOM   2649 C  CG1  . VAL A 1 174 ? -32.594 5.522   -5.071  1.00 34.14  ? 179 VAL C CG1  1 
ATOM   2650 C  CG2  . VAL A 1 174 ? -33.352 6.011   -7.401  1.00 32.11  ? 179 VAL C CG2  1 
ATOM   2651 H  H    . VAL A 1 174 ? -33.218 8.929   -7.248  1.00 38.21  ? 179 VAL C H    1 
ATOM   2652 H  HA   . VAL A 1 174 ? -34.469 7.415   -5.285  1.00 40.42  ? 179 VAL C HA   1 
ATOM   2653 H  HB   . VAL A 1 174 ? -31.884 6.969   -6.337  1.00 35.84  ? 179 VAL C HB   1 
ATOM   2654 H  HG11 . VAL A 1 174 ? -32.461 4.664   -5.509  1.00 41.02  ? 179 VAL C HG11 1 
ATOM   2655 H  HG12 . VAL A 1 174 ? -31.820 5.725   -4.520  1.00 41.02  ? 179 VAL C HG12 1 
ATOM   2656 H  HG13 . VAL A 1 174 ? -33.388 5.477   -4.511  1.00 41.02  ? 179 VAL C HG13 1 
ATOM   2657 H  HG21 . VAL A 1 174 ? -32.629 5.775   -8.007  1.00 38.58  ? 179 VAL C HG21 1 
ATOM   2658 H  HG22 . VAL A 1 174 ? -33.865 5.214   -7.183  1.00 38.58  ? 179 VAL C HG22 1 
ATOM   2659 H  HG23 . VAL A 1 174 ? -33.934 6.661   -7.830  1.00 38.58  ? 179 VAL C HG23 1 
ATOM   2660 N  N    . PRO A 1 175 ? -33.493 8.532   -3.229  1.00 30.29  ? 180 PRO C N    1 
ATOM   2661 C  CA   . PRO A 1 175 ? -32.769 9.065   -2.090  1.00 34.91  ? 180 PRO C CA   1 
ATOM   2662 C  C    . PRO A 1 175 ? -31.499 8.244   -1.836  1.00 31.90  ? 180 PRO C C    1 
ATOM   2663 O  O    . PRO A 1 175 ? -31.482 7.061   -2.194  1.00 31.54  ? 180 PRO C O    1 
ATOM   2664 C  CB   . PRO A 1 175 ? -33.795 8.975   -0.961  1.00 33.82  ? 180 PRO C CB   1 
ATOM   2665 C  CG   . PRO A 1 175 ? -35.126 8.939   -1.663  1.00 35.23  ? 180 PRO C CG   1 
ATOM   2666 C  CD   . PRO A 1 175 ? -34.844 8.127   -2.906  1.00 32.50  ? 180 PRO C CD   1 
ATOM   2667 H  HA   . PRO A 1 175 ? -32.537 10.014  -2.259  1.00 41.94  ? 180 PRO C HA   1 
ATOM   2668 H  HB2  . PRO A 1 175 ? -33.657 8.157   -0.427  1.00 40.62  ? 180 PRO C HB2  1 
ATOM   2669 H  HB3  . PRO A 1 175 ? -33.733 9.760   -0.367  1.00 40.62  ? 180 PRO C HB3  1 
ATOM   2670 H  HG2  . PRO A 1 175 ? -35.806 8.503   -1.107  1.00 42.32  ? 180 PRO C HG2  1 
ATOM   2671 H  HG3  . PRO A 1 175 ? -35.429 9.841   -1.894  1.00 42.32  ? 180 PRO C HG3  1 
ATOM   2672 H  HD2  . PRO A 1 175 ? -34.893 7.163   -2.721  1.00 39.04  ? 180 PRO C HD2  1 
ATOM   2673 H  HD3  . PRO A 1 175 ? -35.471 8.355   -3.628  1.00 39.04  ? 180 PRO C HD3  1 
ATOM   2674 N  N    . SER A 1 176 ? -30.473 8.843   -1.236  1.00 30.86  ? 181 SER C N    1 
ATOM   2675 C  CA   . SER A 1 176 ? -29.155 8.191   -0.995  1.00 30.93  ? 181 SER C CA   1 
ATOM   2676 C  C    . SER A 1 176 ? -29.264 6.884   -0.191  1.00 32.75  ? 181 SER C C    1 
ATOM   2677 O  O    . SER A 1 176 ? -28.499 5.968   -0.497  1.00 39.23  ? 181 SER C O    1 
ATOM   2678 C  CB   . SER A 1 176 ? -28.210 9.175   -0.339  1.00 31.28  ? 181 SER C CB   1 
ATOM   2679 O  OG   . SER A 1 176 ? -28.531 9.413   1.022   1.00 39.28  ? 181 SER C OG   1 
ATOM   2680 H  H    . SER A 1 176 ? -30.531 9.698   -0.956  1.00 37.07  ? 181 SER C H    1 
ATOM   2681 H  HA   . SER A 1 176 ? -28.777 7.956   -1.882  1.00 37.16  ? 181 SER C HA   1 
ATOM   2682 H  HB2  . SER A 1 176 ? -27.298 8.833   -0.401  1.00 37.58  ? 181 SER C HB2  1 
ATOM   2683 H  HB3  . SER A 1 176 ? -28.244 10.021  -0.829  1.00 37.58  ? 181 SER C HB3  1 
ATOM   2684 H  HG   . SER A 1 176 ? -27.989 9.991   1.321   1.00 47.18  ? 181 SER C HG   1 
ATOM   2685 N  N    . GLY A 1 177 ? -30.180 6.785   0.769   1.00 36.84  ? 182 GLY C N    1 
ATOM   2686 C  CA   . GLY A 1 177 ? -30.373 5.570   1.582   1.00 36.95  ? 182 GLY C CA   1 
ATOM   2687 C  C    . GLY A 1 177 ? -30.929 4.416   0.773   1.00 36.52  ? 182 GLY C C    1 
ATOM   2688 O  O    . GLY A 1 177 ? -30.810 3.287   1.250   1.00 36.55  ? 182 GLY C O    1 
ATOM   2689 H  H    . GLY A 1 177 ? -30.739 7.469   0.953   1.00 44.26  ? 182 GLY C H    1 
ATOM   2690 H  HA2  . GLY A 1 177 ? -29.507 5.307   1.972   1.00 44.38  ? 182 GLY C HA2  1 
ATOM   2691 H  HA3  . GLY A 1 177 ? -30.987 5.775   2.322   1.00 44.38  ? 182 GLY C HA3  1 
ATOM   2692 N  N    . LEU A 1 178 ? -31.502 4.690   -0.398  1.00 35.34  ? 183 LEU C N    1 
ATOM   2693 C  CA   . LEU A 1 178 ? -31.995 3.662   -1.339  1.00 32.20  ? 183 LEU C CA   1 
ATOM   2694 C  C    . LEU A 1 178 ? -30.954 3.504   -2.458  1.00 39.06  ? 183 LEU C C    1 
ATOM   2695 O  O    . LEU A 1 178 ? -31.278 2.979   -3.490  1.00 36.95  ? 183 LEU C O    1 
ATOM   2696 C  CB   . LEU A 1 178 ? -33.359 4.087   -1.880  1.00 25.93  ? 183 LEU C CB   1 
ATOM   2697 C  CG   . LEU A 1 178 ? -34.486 4.305   -0.868  1.00 31.58  ? 183 LEU C CG   1 
ATOM   2698 C  CD1  . LEU A 1 178 ? -35.775 4.648   -1.590  1.00 30.35  ? 183 LEU C CD1  1 
ATOM   2699 C  CD2  . LEU A 1 178 ? -34.682 3.088   -0.000  1.00 29.93  ? 183 LEU C CD2  1 
ATOM   2700 H  H    . LEU A 1 178 ? -31.643 5.536   -0.678  1.00 42.46  ? 183 LEU C H    1 
ATOM   2701 H  HA   . LEU A 1 178 ? -32.083 2.801   -0.864  1.00 38.68  ? 183 LEU C HA   1 
ATOM   2702 H  HB2  . LEU A 1 178 ? -33.236 4.924   -2.383  1.00 31.16  ? 183 LEU C HB2  1 
ATOM   2703 H  HB3  . LEU A 1 178 ? -33.659 3.405   -2.524  1.00 31.16  ? 183 LEU C HB3  1 
ATOM   2704 H  HG   . LEU A 1 178 ? -34.241 5.071   -0.288  1.00 37.94  ? 183 LEU C HG   1 
ATOM   2705 H  HD11 . LEU A 1 178 ? -36.289 5.282   -1.061  1.00 36.46  ? 183 LEU C HD11 1 
ATOM   2706 H  HD12 . LEU A 1 178 ? -35.567 5.042   -2.455  1.00 36.46  ? 183 LEU C HD12 1 
ATOM   2707 H  HD13 . LEU A 1 178 ? -36.298 3.839   -1.722  1.00 36.46  ? 183 LEU C HD13 1 
ATOM   2708 H  HD21 . LEU A 1 178 ? -35.583 3.092   0.364   1.00 35.96  ? 183 LEU C HD21 1 
ATOM   2709 H  HD22 . LEU A 1 178 ? -34.551 2.287   -0.535  1.00 35.96  ? 183 LEU C HD22 1 
ATOM   2710 H  HD23 . LEU A 1 178 ? -34.038 3.101   0.727   1.00 35.96  ? 183 LEU C HD23 1 
ATOM   2711 N  N    . ALA A 1 179 ? -29.735 3.979   -2.265  1.00 36.51  ? 184 ALA C N    1 
ATOM   2712 C  CA   . ALA A 1 179 ? -28.669 3.882   -3.284  1.00 35.99  ? 184 ALA C CA   1 
ATOM   2713 C  C    . ALA A 1 179 ? -27.377 3.399   -2.615  1.00 40.69  ? 184 ALA C C    1 
ATOM   2714 O  O    . ALA A 1 179 ? -27.425 2.276   -2.100  1.00 43.88  ? 184 ALA C O    1 
ATOM   2715 C  CB   . ALA A 1 179 ? -28.561 5.203   -3.995  1.00 34.61  ? 184 ALA C CB   1 
ATOM   2716 H  H    . ALA A 1 179 ? -29.479 4.390   -1.506  1.00 43.86  ? 184 ALA C H    1 
ATOM   2717 H  HA   . ALA A 1 179 ? -28.929 3.190   -3.950  1.00 43.23  ? 184 ALA C HA   1 
ATOM   2718 H  HB1  . ALA A 1 179 ? -27.806 5.187   -4.608  1.00 41.57  ? 184 ALA C HB1  1 
ATOM   2719 H  HB2  . ALA A 1 179 ? -29.377 5.371   -4.496  1.00 41.57  ? 184 ALA C HB2  1 
ATOM   2720 H  HB3  . ALA A 1 179 ? -28.435 5.914   -3.344  1.00 41.57  ? 184 ALA C HB3  1 
ATOM   2721 N  N    . TYR A 1 180 ? -26.299 4.178   -2.594  1.00 38.09  ? 185 TYR C N    1 
ATOM   2722 C  CA   . TYR A 1 180 ? -24.990 3.718   -2.058  1.00 42.79  ? 185 TYR C CA   1 
ATOM   2723 C  C    . TYR A 1 180 ? -24.797 4.262   -0.645  1.00 37.30  ? 185 TYR C C    1 
ATOM   2724 O  O    . TYR A 1 180 ? -23.875 3.804   0.029   1.00 39.82  ? 185 TYR C O    1 
ATOM   2725 C  CB   . TYR A 1 180 ? -23.979 4.107   -3.135  1.00 34.87  ? 185 TYR C CB   1 
ATOM   2726 C  CG   . TYR A 1 180 ? -24.286 3.477   -4.483  1.00 38.24  ? 185 TYR C CG   1 
ATOM   2727 C  CD1  . TYR A 1 180 ? -24.229 2.101   -4.654  1.00 39.42  ? 185 TYR C CD1  1 
ATOM   2728 C  CD2  . TYR A 1 180 ? -24.661 4.253   -5.570  1.00 39.84  ? 185 TYR C CD2  1 
ATOM   2729 C  CE1  . TYR A 1 180 ? -24.518 1.516   -5.872  1.00 37.52  ? 185 TYR C CE1  1 
ATOM   2730 C  CE2  . TYR A 1 180 ? -24.952 3.680   -6.795  1.00 44.04  ? 185 TYR C CE2  1 
ATOM   2731 C  CZ   . TYR A 1 180 ? -24.881 2.307   -6.945  1.00 36.48  ? 185 TYR C CZ   1 
ATOM   2732 O  OH   . TYR A 1 180 ? -25.167 1.726   -8.140  1.00 38.49  ? 185 TYR C OH   1 
ATOM   2733 H  H    . TYR A 1 180 ? -26.301 5.026   -2.899  1.00 45.75  ? 185 TYR C H    1 
ATOM   2734 H  HA   . TYR A 1 180 ? -25.002 2.729   -2.002  1.00 51.39  ? 185 TYR C HA   1 
ATOM   2735 H  HB2  . TYR A 1 180 ? -23.981 5.085   -3.229  1.00 41.89  ? 185 TYR C HB2  1 
ATOM   2736 H  HB3  . TYR A 1 180 ? -23.084 3.824   -2.843  1.00 41.89  ? 185 TYR C HB3  1 
ATOM   2737 H  HD1  . TYR A 1 180 ? -23.984 1.554   -3.924  1.00 47.35  ? 185 TYR C HD1  1 
ATOM   2738 H  HD2  . TYR A 1 180 ? -24.711 5.191   -5.475  1.00 47.85  ? 185 TYR C HD2  1 
ATOM   2739 H  HE1  . TYR A 1 180 ? -24.472 0.581   -5.971  1.00 45.07  ? 185 TYR C HE1  1 
ATOM   2740 H  HE2  . TYR A 1 180 ? -25.199 4.223   -7.524  1.00 52.89  ? 185 TYR C HE2  1 
ATOM   2741 H  HH   . TYR A 1 180 ? -25.923 1.321   -8.091  1.00 46.23  ? 185 TYR C HH   1 
ATOM   2742 N  N    . GLY A 1 181 ? -25.629 5.199   -0.204  1.00 40.65  ? 186 GLY C N    1 
ATOM   2743 C  CA   . GLY A 1 181 ? -25.592 5.691   1.182   1.00 43.40  ? 186 GLY C CA   1 
ATOM   2744 C  C    . GLY A 1 181 ? -24.307 6.394   1.559   1.00 44.46  ? 186 GLY C C    1 
ATOM   2745 O  O    . GLY A 1 181 ? -23.712 7.025   0.680   1.00 40.97  ? 186 GLY C O    1 
ATOM   2746 H  H    . GLY A 1 181 ? -26.249 5.581   -0.743  1.00 48.82  ? 186 GLY C H    1 
ATOM   2747 H  HA2  . GLY A 1 181 ? -26.345 6.311   1.313   1.00 52.12  ? 186 GLY C HA2  1 
ATOM   2748 H  HA3  . GLY A 1 181 ? -25.736 4.927   1.776   1.00 52.12  ? 186 GLY C HA3  1 
ATOM   2749 N  N    . PRO A 1 182 ? -23.857 6.320   2.830   1.00 43.79  ? 187 PRO C N    1 
ATOM   2750 C  CA   . PRO A 1 182 ? -22.685 7.065   3.275   1.00 45.65  ? 187 PRO C CA   1 
ATOM   2751 C  C    . PRO A 1 182 ? -21.349 6.441   2.912   1.00 53.07  ? 187 PRO C C    1 
ATOM   2752 O  O    . PRO A 1 182 ? -20.521 6.212   3.798   1.00 56.89  ? 187 PRO C O    1 
ATOM   2753 C  CB   . PRO A 1 182 ? -22.978 7.044   4.771   1.00 50.53  ? 187 PRO C CB   1 
ATOM   2754 C  CG   . PRO A 1 182 ? -23.485 5.661   5.016   1.00 51.19  ? 187 PRO C CG   1 
ATOM   2755 C  CD   . PRO A 1 182 ? -24.452 5.509   3.876   1.00 40.25  ? 187 PRO C CD   1 
ATOM   2756 H  HA   . PRO A 1 182 ? -22.731 7.993   2.937   1.00 54.83  ? 187 PRO C HA   1 
ATOM   2757 H  HB2  . PRO A 1 182 ? -22.173 7.230   5.303   1.00 60.68  ? 187 PRO C HB2  1 
ATOM   2758 H  HB3  . PRO A 1 182 ? -23.666 7.710   4.998   1.00 60.68  ? 187 PRO C HB3  1 
ATOM   2759 H  HG2  . PRO A 1 182 ? -22.766 4.998   4.967   1.00 61.48  ? 187 PRO C HG2  1 
ATOM   2760 H  HG3  . PRO A 1 182 ? -23.939 5.593   5.881   1.00 61.48  ? 187 PRO C HG3  1 
ATOM   2761 H  HD2  . PRO A 1 182 ? -24.525 4.570   3.599   1.00 48.35  ? 187 PRO C HD2  1 
ATOM   2762 H  HD3  . PRO A 1 182 ? -25.341 5.846   4.121   1.00 48.35  ? 187 PRO C HD3  1 
ATOM   2763 N  N    . ARG A 1 183 ? -21.117 6.203   1.626   1.00 58.94  ? 188 ARG C N    1 
ATOM   2764 C  CA   . ARG A 1 183 ? -19.899 5.511   1.154   1.00 59.45  ? 188 ARG C CA   1 
ATOM   2765 C  C    . ARG A 1 183 ? -19.464 6.098   -0.184  1.00 63.33  ? 188 ARG C C    1 
ATOM   2766 O  O    . ARG A 1 183 ? -20.338 6.386   -1.017  1.00 74.40  ? 188 ARG C O    1 
ATOM   2767 C  CB   . ARG A 1 183 ? -20.186 4.011   1.036   1.00 67.67  ? 188 ARG C CB   1 
ATOM   2768 C  CG   . ARG A 1 183 ? -20.653 3.487   -0.313  1.00 71.76  ? 188 ARG C CG   1 
ATOM   2769 C  CD   . ARG A 1 183 ? -21.151 2.061   -0.197  1.00 75.60  ? 188 ARG C CD   1 
ATOM   2770 N  NE   . ARG A 1 183 ? -21.782 1.615   -1.442  1.00 76.93  ? 188 ARG C NE   1 
ATOM   2771 C  CZ   . ARG A 1 183 ? -22.304 0.414   -1.632  1.00 86.44  ? 188 ARG C CZ   1 
ATOM   2772 N  NH1  . ARG A 1 183 ? -23.577 0.196   -1.362  1.00 90.69  ? 188 ARG C NH1  1 
ATOM   2773 N  NH2  . ARG A 1 183 ? -21.554 -0.564  -2.100  1.00 79.35  ? 188 ARG C NH2  1 
ATOM   2774 H  H    . ARG A 1 183 ? -21.688 6.468   0.982   1.00 70.77  ? 188 ARG C H    1 
ATOM   2775 H  HA   . ARG A 1 183 ? -19.171 5.655   1.807   1.00 71.39  ? 188 ARG C HA   1 
ATOM   2776 H  HB2  . ARG A 1 183 ? -19.370 3.528   1.284   1.00 81.25  ? 188 ARG C HB2  1 
ATOM   2777 H  HB3  . ARG A 1 183 ? -20.870 3.785   1.701   1.00 81.25  ? 188 ARG C HB3  1 
ATOM   2778 H  HG2  . ARG A 1 183 ? -21.380 4.050   -0.652  1.00 86.15  ? 188 ARG C HG2  1 
ATOM   2779 H  HG3  . ARG A 1 183 ? -19.910 3.514   -0.953  1.00 86.15  ? 188 ARG C HG3  1 
ATOM   2780 H  HD2  . ARG A 1 183 ? -20.401 1.472   0.015   1.00 90.77  ? 188 ARG C HD2  1 
ATOM   2781 H  HD3  . ARG A 1 183 ? -21.799 2.004   0.533   1.00 90.77  ? 188 ARG C HD3  1 
ATOM   2782 H  HE   . ARG A 1 183 ? -21.822 2.178   -2.102  1.00 92.36  ? 188 ARG C HE   1 
ATOM   2783 H  HH11 . ARG A 1 183 ? -24.100 0.876   -1.150  1.00 108.87 ? 188 ARG C HH11 1 
ATOM   2784 H  HH12 . ARG A 1 183 ? -23.901 -0.625  -1.405  1.00 108.87 ? 188 ARG C HH12 1 
ATOM   2785 H  HH21 . ARG A 1 183 ? -20.679 -0.459  -2.148  1.00 95.27  ? 188 ARG C HH21 1 
ATOM   2786 H  HH22 . ARG A 1 183 ? -21.933 -1.320  -2.359  1.00 95.27  ? 188 ARG C HH22 1 
ATOM   2787 N  N    . SER A 1 184 ? -18.166 6.276   -0.365  1.00 65.52  ? 189 SER C N    1 
ATOM   2788 C  CA   . SER A 1 184 ? -17.606 6.770   -1.644  1.00 79.80  ? 189 SER C CA   1 
ATOM   2789 C  C    . SER A 1 184 ? -16.130 6.377   -1.671  1.00 87.87  ? 189 SER C C    1 
ATOM   2790 O  O    . SER A 1 184 ? -15.291 7.190   -1.238  1.00 86.38  ? 189 SER C O    1 
ATOM   2791 C  CB   . SER A 1 184 ? -17.796 8.246   -1.811  1.00 74.71  ? 189 SER C CB   1 
ATOM   2792 O  OG   . SER A 1 184 ? -16.934 8.768   -2.812  1.00 82.06  ? 189 SER C OG   1 
ATOM   2793 H  H    . SER A 1 184 ? -17.568 6.093   0.285   1.00 78.66  ? 189 SER C H    1 
ATOM   2794 H  HA   . SER A 1 184 ? -18.064 6.304   -2.388  1.00 95.80  ? 189 SER C HA   1 
ATOM   2795 H  HB2  . SER A 1 184 ? -18.722 8.423   -2.059  1.00 89.70  ? 189 SER C HB2  1 
ATOM   2796 H  HB3  . SER A 1 184 ? -17.620 8.693   -0.960  1.00 89.70  ? 189 SER C HB3  1 
ATOM   2797 H  HG   . SER A 1 184 ? -16.852 9.603   -2.690  1.00 98.51  ? 189 SER C HG   1 
ATOM   2798 N  N    . VAL A 1 185 ? -15.840 5.153   -2.098  1.00 90.57  ? 190 VAL C N    1 
ATOM   2799 C  CA   . VAL A 1 185 ? -14.432 4.683   -2.218  1.00 91.63  ? 190 VAL C CA   1 
ATOM   2800 C  C    . VAL A 1 185 ? -13.852 5.333   -3.476  1.00 88.69  ? 190 VAL C C    1 
ATOM   2801 O  O    . VAL A 1 185 ? -12.651 5.652   -3.475  1.00 91.10  ? 190 VAL C O    1 
ATOM   2802 C  CB   . VAL A 1 185 ? -14.354 3.150   -2.277  1.00 94.59  ? 190 VAL C CB   1 
ATOM   2803 C  CG1  . VAL A 1 185 ? -12.911 2.671   -2.322  1.00 92.29  ? 190 VAL C CG1  1 
ATOM   2804 C  CG2  . VAL A 1 185 ? -15.099 2.512   -1.114  1.00 87.61  ? 190 VAL C CG2  1 
ATOM   2805 H  H    . VAL A 1 185 ? -16.484 4.572   -2.345  1.00 108.73 ? 190 VAL C H    1 
ATOM   2806 H  HA   . VAL A 1 185 ? -13.929 4.991   -1.442  1.00 110.00 ? 190 VAL C HA   1 
ATOM   2807 H  HB   . VAL A 1 185 ? -14.795 2.869   -3.112  1.00 113.55 ? 190 VAL C HB   1 
ATOM   2808 H  HG11 . VAL A 1 185 ? -12.852 1.777   -1.947  1.00 110.80 ? 190 VAL C HG11 1 
ATOM   2809 H  HG12 . VAL A 1 185 ? -12.601 2.657   -3.243  1.00 110.80 ? 190 VAL C HG12 1 
ATOM   2810 H  HG13 . VAL A 1 185 ? -12.354 3.276   -1.803  1.00 110.80 ? 190 VAL C HG13 1 
ATOM   2811 H  HG21 . VAL A 1 185 ? -14.728 1.632   -0.933  1.00 105.18 ? 190 VAL C HG21 1 
ATOM   2812 H  HG22 . VAL A 1 185 ? -15.005 3.071   -0.325  1.00 105.18 ? 190 VAL C HG22 1 
ATOM   2813 H  HG23 . VAL A 1 185 ? -16.040 2.426   -1.339  1.00 105.18 ? 190 VAL C HG23 1 
ATOM   2814 N  N    . GLY A 1 186 ? -14.688 5.540   -4.490  1.00 90.54  ? 191 GLY C N    1 
ATOM   2815 C  CA   . GLY A 1 186 ? -14.249 6.154   -5.753  1.00 84.50  ? 191 GLY C CA   1 
ATOM   2816 C  C    . GLY A 1 186 ? -15.402 6.295   -6.716  1.00 81.08  ? 191 GLY C C    1 
ATOM   2817 O  O    . GLY A 1 186 ? -16.560 6.226   -6.258  1.00 84.26  ? 191 GLY C O    1 
ATOM   2818 H  H    . GLY A 1 186 ? -15.559 5.304   -4.441  1.00 108.69 ? 191 GLY C H    1 
ATOM   2819 H  HA2  . GLY A 1 186 ? -13.864 7.041   -5.566  1.00 101.44 ? 191 GLY C HA2  1 
ATOM   2820 H  HA3  . GLY A 1 186 ? -13.548 5.594   -6.159  1.00 101.44 ? 191 GLY C HA3  1 
ATOM   2821 N  N    . GLY A 1 187 ? -15.113 6.464   -8.003  1.00 77.31  ? 192 GLY C N    1 
ATOM   2822 C  CA   . GLY A 1 187 ? -16.154 6.693   -9.017  1.00 69.00  ? 192 GLY C CA   1 
ATOM   2823 C  C    . GLY A 1 187 ? -16.562 8.143   -8.994  1.00 66.63  ? 192 GLY C C    1 
ATOM   2824 O  O    . GLY A 1 187 ? -15.916 8.915   -8.261  1.00 71.66  ? 192 GLY C O    1 
ATOM   2825 H  H    . GLY A 1 187 ? -14.260 6.444   -8.302  1.00 92.82  ? 192 GLY C H    1 
ATOM   2826 H  HA2  . GLY A 1 187 ? -15.802 6.457   -9.907  1.00 82.85  ? 192 GLY C HA2  1 
ATOM   2827 H  HA3  . GLY A 1 187 ? -16.932 6.119   -8.830  1.00 82.85  ? 192 GLY C HA3  1 
ATOM   2828 N  N    . PRO A 1 188 ? -17.590 8.562   -9.754  1.00 59.24  ? 193 PRO C N    1 
ATOM   2829 C  CA   . PRO A 1 188 ? -18.090 9.923   -9.662  1.00 64.23  ? 193 PRO C CA   1 
ATOM   2830 C  C    . PRO A 1 188 ? -19.143 10.069  -8.573  1.00 59.44  ? 193 PRO C C    1 
ATOM   2831 O  O    . PRO A 1 188 ? -19.624 11.199  -8.387  1.00 59.25  ? 193 PRO C O    1 
ATOM   2832 C  CB   . PRO A 1 188 ? -18.652 10.110  -11.067 1.00 59.41  ? 193 PRO C CB   1 
ATOM   2833 C  CG   . PRO A 1 188 ? -19.215 8.754   -11.414 1.00 63.10  ? 193 PRO C CG   1 
ATOM   2834 C  CD   . PRO A 1 188 ? -18.292 7.757   -10.736 1.00 64.68  ? 193 PRO C CD   1 
ATOM   2835 H  HA   . PRO A 1 188 ? -17.348 10.558  -9.512  1.00 77.12  ? 193 PRO C HA   1 
ATOM   2836 H  HB2  . PRO A 1 188 ? -19.358 10.797  -11.077 1.00 71.34  ? 193 PRO C HB2  1 
ATOM   2837 H  HB3  . PRO A 1 188 ? -17.941 10.369  -11.698 1.00 71.34  ? 193 PRO C HB3  1 
ATOM   2838 H  HG2  . PRO A 1 188 ? -20.131 8.663   -11.077 1.00 75.76  ? 193 PRO C HG2  1 
ATOM   2839 H  HG3  . PRO A 1 188 ? -19.222 8.617   -12.385 1.00 75.76  ? 193 PRO C HG3  1 
ATOM   2840 H  HD2  . PRO A 1 188 ? -18.807 7.041   -10.302 1.00 77.66  ? 193 PRO C HD2  1 
ATOM   2841 H  HD3  . PRO A 1 188 ? -17.666 7.360   -11.382 1.00 77.66  ? 193 PRO C HD3  1 
ATOM   2842 N  N    . ILE A 1 189 ? -19.482 8.984   -7.872  1.00 54.44  ? 194 ILE C N    1 
ATOM   2843 C  CA   . ILE A 1 189 ? -20.538 8.992   -6.819  1.00 45.63  ? 194 ILE C CA   1 
ATOM   2844 C  C    . ILE A 1 189 ? -19.876 9.180   -5.449  1.00 49.13  ? 194 ILE C C    1 
ATOM   2845 O  O    . ILE A 1 189 ? -19.176 8.261   -4.989  1.00 51.27  ? 194 ILE C O    1 
ATOM   2846 C  CB   . ILE A 1 189 ? -21.398 7.716   -6.892  1.00 46.02  ? 194 ILE C CB   1 
ATOM   2847 C  CG1  . ILE A 1 189 ? -22.117 7.595   -8.236  1.00 48.51  ? 194 ILE C CG1  1 
ATOM   2848 C  CG2  . ILE A 1 189 ? -22.380 7.650   -5.721  1.00 49.02  ? 194 ILE C CG2  1 
ATOM   2849 C  CD1  . ILE A 1 189 ? -23.075 6.421   -8.333  1.00 46.29  ? 194 ILE C CD1  1 
ATOM   2850 H  H    . ILE A 1 189 ? -19.093 8.183   -8.013  1.00 65.38  ? 194 ILE C H    1 
ATOM   2851 H  HA   . ILE A 1 189 ? -21.126 9.755   -6.979  1.00 54.81  ? 194 ILE C HA   1 
ATOM   2852 H  HB   . ILE A 1 189 ? -20.796 6.951   -6.815  1.00 55.26  ? 194 ILE C HB   1 
ATOM   2853 H  HG12 . ILE A 1 189 ? -22.618 8.420   -8.397  1.00 58.26  ? 194 ILE C HG12 1 
ATOM   2854 H  HG13 . ILE A 1 189 ? -21.445 7.511   -8.943  1.00 58.26  ? 194 ILE C HG13 1 
ATOM   2855 H  HG21 . ILE A 1 189 ? -22.568 6.721   -5.504  1.00 58.87  ? 194 ILE C HG21 1 
ATOM   2856 H  HG22 . ILE A 1 189 ? -21.994 8.090   -4.946  1.00 58.87  ? 194 ILE C HG22 1 
ATOM   2857 H  HG23 . ILE A 1 189 ? -23.208 8.098   -5.965  1.00 58.87  ? 194 ILE C HG23 1 
ATOM   2858 H  HD11 . ILE A 1 189 ? -23.204 6.184   -9.270  1.00 55.60  ? 194 ILE C HD11 1 
ATOM   2859 H  HD12 . ILE A 1 189 ? -22.705 5.657   -7.853  1.00 55.60  ? 194 ILE C HD12 1 
ATOM   2860 H  HD13 . ILE A 1 189 ? -23.936 6.663   -7.941  1.00 55.60  ? 194 ILE C HD13 1 
ATOM   2861 N  N    . GLY A 1 190 ? -20.112 10.326  -4.820  1.00 51.60  ? 195 GLY C N    1 
ATOM   2862 C  CA   . GLY A 1 190 ? -19.576 10.600  -3.482  1.00 48.38  ? 195 GLY C CA   1 
ATOM   2863 C  C    . GLY A 1 190 ? -20.562 10.222  -2.399  1.00 45.20  ? 195 GLY C C    1 
ATOM   2864 O  O    . GLY A 1 190 ? -21.550 9.549   -2.709  1.00 51.16  ? 195 GLY C O    1 
ATOM   2865 H  H    . GLY A 1 190 ? -20.617 10.977  -5.193  1.00 61.96  ? 195 GLY C H    1 
ATOM   2866 H  HA2  . GLY A 1 190 ? -18.745 10.091  -3.360  1.00 58.10  ? 195 GLY C HA2  1 
ATOM   2867 H  HA3  . GLY A 1 190 ? -19.360 11.558  -3.416  1.00 58.10  ? 195 GLY C HA3  1 
ATOM   2868 N  N    . PRO A 1 191 ? -20.348 10.636  -1.136  1.00 48.06  ? 196 PRO C N    1 
ATOM   2869 C  CA   . PRO A 1 191 ? -21.225 10.218  -0.055  1.00 43.34  ? 196 PRO C CA   1 
ATOM   2870 C  C    . PRO A 1 191 ? -22.606 10.864  -0.001  1.00 38.12  ? 196 PRO C C    1 
ATOM   2871 O  O    . PRO A 1 191 ? -22.718 12.023  -0.377  1.00 34.58  ? 196 PRO C O    1 
ATOM   2872 C  CB   . PRO A 1 191 ? -20.349 10.605  1.142   1.00 43.22  ? 196 PRO C CB   1 
ATOM   2873 C  CG   . PRO A 1 191 ? -19.657 11.863  0.706   1.00 47.16  ? 196 PRO C CG   1 
ATOM   2874 C  CD   . PRO A 1 191 ? -19.283 11.534  -0.718  1.00 44.96  ? 196 PRO C CD   1 
ATOM   2875 H  HA   . PRO A 1 191 ? -21.321 9.235   -0.083  1.00 52.05  ? 196 PRO C HA   1 
ATOM   2876 H  HB2  . PRO A 1 191 ? -20.900 10.768  1.942   1.00 51.90  ? 196 PRO C HB2  1 
ATOM   2877 H  HB3  . PRO A 1 191 ? -19.696 9.898   1.338   1.00 51.90  ? 196 PRO C HB3  1 
ATOM   2878 H  HG2  . PRO A 1 191 ? -20.258 12.636  0.745   1.00 56.63  ? 196 PRO C HG2  1 
ATOM   2879 H  HG3  . PRO A 1 191 ? -18.863 12.041  1.252   1.00 56.63  ? 196 PRO C HG3  1 
ATOM   2880 H  HD2  . PRO A 1 191 ? -19.264 12.346  -1.271  1.00 53.99  ? 196 PRO C HD2  1 
ATOM   2881 H  HD3  . PRO A 1 191 ? -18.408 11.089  -0.759  1.00 53.99  ? 196 PRO C HD3  1 
ATOM   2882 N  N    . ASN A 1 192 ? -23.627 10.123  0.435   1.00 39.72  ? 197 ASN C N    1 
ATOM   2883 C  CA   . ASN A 1 192 ? -25.021 10.631  0.607   1.00 38.66  ? 197 ASN C CA   1 
ATOM   2884 C  C    . ASN A 1 192 ? -25.517 11.314  -0.667  1.00 33.40  ? 197 ASN C C    1 
ATOM   2885 O  O    . ASN A 1 192 ? -26.139 12.375  -0.561  1.00 35.37  ? 197 ASN C O    1 
ATOM   2886 C  CB   . ASN A 1 192 ? -25.127 11.530  1.833   1.00 34.56  ? 197 ASN C CB   1 
ATOM   2887 C  CG   . ASN A 1 192 ? -24.964 10.784  3.133   1.00 37.41  ? 197 ASN C CG   1 
ATOM   2888 O  OD1  . ASN A 1 192 ? -25.007 9.551   3.171   1.00 41.29  ? 197 ASN C OD1  1 
ATOM   2889 N  ND2  . ASN A 1 192 ? -24.803 11.526  4.216   1.00 41.44  ? 197 ASN C ND2  1 
ATOM   2890 H  H    . ASN A 1 192 ? -23.509 9.257   0.655   1.00 47.71  ? 197 ASN C H    1 
ATOM   2891 H  HA   . ASN A 1 192 ? -25.603 9.857   0.763   1.00 46.43  ? 197 ASN C HA   1 
ATOM   2892 H  HB2  . ASN A 1 192 ? -24.443 12.225  1.778   1.00 41.51  ? 197 ASN C HB2  1 
ATOM   2893 H  HB3  . ASN A 1 192 ? -26.000 11.969  1.841   1.00 41.51  ? 197 ASN C HB3  1 
ATOM   2894 H  HD21 . ASN A 1 192 ? -24.512 11.160  4.969   1.00 49.78  ? 197 ASN C HD21 1 
ATOM   2895 H  HD22 . ASN A 1 192 ? -24.983 12.395  4.180   1.00 49.78  ? 197 ASN C HD22 1 
ATOM   2896 N  N    . GLU A 1 193 ? -25.315 10.684  -1.815  1.00 35.01  ? 198 GLU C N    1 
ATOM   2897 C  CA   . GLU A 1 193 ? -25.692 11.280  -3.120  1.00 41.15  ? 198 GLU C CA   1 
ATOM   2898 C  C    . GLU A 1 193 ? -27.058 10.780  -3.619  1.00 31.30  ? 198 GLU C C    1 
ATOM   2899 O  O    . GLU A 1 193 ? -27.223 9.563   -3.720  1.00 35.68  ? 198 GLU C O    1 
ATOM   2900 C  CB   . GLU A 1 193 ? -24.584 10.986  -4.126  1.00 36.72  ? 198 GLU C CB   1 
ATOM   2901 C  CG   . GLU A 1 193 ? -24.634 11.883  -5.353  1.00 50.45  ? 198 GLU C CG   1 
ATOM   2902 C  CD   . GLU A 1 193 ? -23.612 13.002  -5.340  1.00 58.61  ? 198 GLU C CD   1 
ATOM   2903 O  OE1  . GLU A 1 193 ? -22.403 12.702  -5.364  1.00 49.61  ? 198 GLU C OE1  1 
ATOM   2904 O  OE2  . GLU A 1 193 ? -24.029 14.175  -5.306  1.00 68.38  ? 198 GLU C OE2  1 
ATOM   2905 H  H    . GLU A 1 193 ? -24.935 9.867   -1.844  1.00 42.06  ? 198 GLU C H    1 
ATOM   2906 H  HA   . GLU A 1 193 ? -25.737 12.260  -3.015  1.00 49.43  ? 198 GLU C HA   1 
ATOM   2907 H  HB2  . GLU A 1 193 ? -23.720 11.097  -3.678  1.00 44.11  ? 198 GLU C HB2  1 
ATOM   2908 H  HB3  . GLU A 1 193 ? -24.654 10.052  -4.409  1.00 44.11  ? 198 GLU C HB3  1 
ATOM   2909 H  HG2  . GLU A 1 193 ? -24.490 11.337  -6.152  1.00 60.59  ? 198 GLU C HG2  1 
ATOM   2910 H  HG3  . GLU A 1 193 ? -25.526 12.278  -5.419  1.00 60.59  ? 198 GLU C HG3  1 
ATOM   2911 N  N    . THR A 1 194 ? -27.986 11.686  -3.923  1.00 35.31  ? 199 THR C N    1 
ATOM   2912 C  CA   . THR A 1 194 ? -29.298 11.364  -4.520  1.00 32.67  ? 199 THR C CA   1 
ATOM   2913 C  C    . THR A 1 194 ? -29.064 11.166  -6.000  1.00 35.32  ? 199 THR C C    1 
ATOM   2914 O  O    . THR A 1 194 ? -28.345 11.980  -6.563  1.00 41.07  ? 199 THR C O    1 
ATOM   2915 C  CB   . THR A 1 194 ? -30.300 12.476  -4.210  1.00 34.44  ? 199 THR C CB   1 
ATOM   2916 O  OG1  . THR A 1 194 ? -30.783 12.220  -2.897  1.00 44.29  ? 199 THR C OG1  1 
ATOM   2917 C  CG2  . THR A 1 194 ? -31.480 12.509  -5.164  1.00 40.40  ? 199 THR C CG2  1 
ATOM   2918 H  H    . THR A 1 194 ? -27.879 12.569  -3.786  1.00 42.42  ? 199 THR C H    1 
ATOM   2919 H  HA   . THR A 1 194 ? -29.627 10.527  -4.130  1.00 39.24  ? 199 THR C HA   1 
ATOM   2920 H  HB   . THR A 1 194 ? -29.846 13.352  -4.226  1.00 41.37  ? 199 THR C HB   1 
ATOM   2921 H  HG1  . THR A 1 194 ? -31.461 12.730  -2.735  1.00 53.19  ? 199 THR C HG1  1 
ATOM   2922 H  HG21 . THR A 1 194 ? -32.221 12.982  -4.747  1.00 48.53  ? 199 THR C HG21 1 
ATOM   2923 H  HG22 . THR A 1 194 ? -31.225 12.969  -5.982  1.00 48.53  ? 199 THR C HG22 1 
ATOM   2924 H  HG23 . THR A 1 194 ? -31.756 11.602  -5.374  1.00 48.53  ? 199 THR C HG23 1 
ATOM   2925 N  N    . LEU A 1 195 ? -29.635 10.130  -6.609  1.00 34.00  ? 200 LEU C N    1 
ATOM   2926 C  CA   . LEU A 1 195 ? -29.380 9.774   -8.027  1.00 32.66  ? 200 LEU C CA   1 
ATOM   2927 C  C    . LEU A 1 195 ? -30.659 9.849   -8.878  1.00 32.82  ? 200 LEU C C    1 
ATOM   2928 O  O    . LEU A 1 195 ? -31.739 9.729   -8.304  1.00 35.79  ? 200 LEU C O    1 
ATOM   2929 C  CB   . LEU A 1 195 ? -28.767 8.374   -8.030  1.00 37.87  ? 200 LEU C CB   1 
ATOM   2930 C  CG   . LEU A 1 195 ? -27.552 8.142   -7.126  1.00 41.62  ? 200 LEU C CG   1 
ATOM   2931 C  CD1  . LEU A 1 195 ? -26.983 6.753   -7.369  1.00 35.50  ? 200 LEU C CD1  1 
ATOM   2932 C  CD2  . LEU A 1 195 ? -26.478 9.205   -7.306  1.00 36.42  ? 200 LEU C CD2  1 
ATOM   2933 H  H    . LEU A 1 195 ? -30.221 9.600   -6.175  1.00 40.85  ? 200 LEU C H    1 
ATOM   2934 H  HA   . LEU A 1 195 ? -28.727 10.413  -8.407  1.00 39.24  ? 200 LEU C HA   1 
ATOM   2935 H  HB2  . LEU A 1 195 ? -29.469 7.733   -7.771  1.00 45.49  ? 200 LEU C HB2  1 
ATOM   2936 H  HB3  . LEU A 1 195 ? -28.508 8.154   -8.955  1.00 45.49  ? 200 LEU C HB3  1 
ATOM   2937 H  HG   . LEU A 1 195 ? -27.860 8.180   -6.184  1.00 49.99  ? 200 LEU C HG   1 
ATOM   2938 H  HD11 . LEU A 1 195 ? -26.062 6.719   -7.059  1.00 42.65  ? 200 LEU C HD11 1 
ATOM   2939 H  HD12 . LEU A 1 195 ? -27.510 6.096   -6.883  1.00 42.65  ? 200 LEU C HD12 1 
ATOM   2940 H  HD13 . LEU A 1 195 ? -27.011 6.551   -8.319  1.00 42.65  ? 200 LEU C HD13 1 
ATOM   2941 H  HD21 . LEU A 1 195 ? -25.600 8.792   -7.255  1.00 43.74  ? 200 LEU C HD21 1 
ATOM   2942 H  HD22 . LEU A 1 195 ? -26.582 9.633   -8.173  1.00 43.74  ? 200 LEU C HD22 1 
ATOM   2943 H  HD23 . LEU A 1 195 ? -26.560 9.873   -6.605  1.00 43.74  ? 200 LEU C HD23 1 
ATOM   2944 N  N    . ILE A 1 196 ? -30.526 10.072  -10.185 1.00 33.68  ? 201 ILE C N    1 
ATOM   2945 C  CA   . ILE A 1 196 ? -31.665 10.125  -11.144 1.00 30.51  ? 201 ILE C CA   1 
ATOM   2946 C  C    . ILE A 1 196 ? -31.405 9.066   -12.224 1.00 38.66  ? 201 ILE C C    1 
ATOM   2947 O  O    . ILE A 1 196 ? -30.310 9.069   -12.786 1.00 40.77  ? 201 ILE C O    1 
ATOM   2948 C  CB   . ILE A 1 196 ? -31.839 11.526  -11.752 1.00 39.03  ? 201 ILE C CB   1 
ATOM   2949 C  CG1  . ILE A 1 196 ? -32.022 12.610  -10.694 1.00 35.90  ? 201 ILE C CG1  1 
ATOM   2950 C  CG2  . ILE A 1 196 ? -32.992 11.540  -12.753 1.00 33.53  ? 201 ILE C CG2  1 
ATOM   2951 C  CD1  . ILE A 1 196 ? -31.321 13.911  -11.030 1.00 43.95  ? 201 ILE C CD1  1 
ATOM   2952 H  H    . ILE A 1 196 ? -29.717 10.215  -10.556 1.00 40.46  ? 201 ILE C H    1 
ATOM   2953 H  HA   . ILE A 1 196 ? -32.483 9.895   -10.674 1.00 36.65  ? 201 ILE C HA   1 
ATOM   2954 H  HB   . ILE A 1 196 ? -31.019 11.735  -12.243 1.00 46.88  ? 201 ILE C HB   1 
ATOM   2955 H  HG12 . ILE A 1 196 ? -32.980 12.787  -10.592 1.00 43.12  ? 201 ILE C HG12 1 
ATOM   2956 H  HG13 . ILE A 1 196 ? -31.687 12.286  -9.836  1.00 43.12  ? 201 ILE C HG13 1 
ATOM   2957 H  HG21 . ILE A 1 196 ? -33.285 12.455  -12.897 1.00 40.28  ? 201 ILE C HG21 1 
ATOM   2958 H  HG22 . ILE A 1 196 ? -32.698 11.161  -13.598 1.00 40.28  ? 201 ILE C HG22 1 
ATOM   2959 H  HG23 . ILE A 1 196 ? -33.733 11.017  -12.404 1.00 40.28  ? 201 ILE C HG23 1 
ATOM   2960 H  HD11 . ILE A 1 196 ? -31.175 14.430  -10.216 1.00 52.78  ? 201 ILE C HD11 1 
ATOM   2961 H  HD12 . ILE A 1 196 ? -30.461 13.716  -11.449 1.00 52.78  ? 201 ILE C HD12 1 
ATOM   2962 H  HD13 . ILE A 1 196 ? -31.874 14.425  -11.648 1.00 52.78  ? 201 ILE C HD13 1 
ATOM   2963 N  N    . PHE A 1 197 ? -32.370 8.198   -12.497 1.00 31.69  ? 202 PHE C N    1 
ATOM   2964 C  CA   . PHE A 1 197 ? -32.196 7.116   -13.492 1.00 34.19  ? 202 PHE C CA   1 
ATOM   2965 C  C    . PHE A 1 197 ? -33.353 7.052   -14.466 1.00 27.49  ? 202 PHE C C    1 
ATOM   2966 O  O    . PHE A 1 197 ? -34.489 7.102   -14.014 1.00 32.67  ? 202 PHE C O    1 
ATOM   2967 C  CB   . PHE A 1 197 ? -32.140 5.706   -12.900 1.00 34.17  ? 202 PHE C CB   1 
ATOM   2968 C  CG   . PHE A 1 197 ? -30.948 5.321   -12.039 1.00 34.61  ? 202 PHE C CG   1 
ATOM   2969 C  CD1  . PHE A 1 197 ? -29.858 4.664   -12.592 1.00 29.76  ? 202 PHE C CD1  1 
ATOM   2970 C  CD2  . PHE A 1 197 ? -30.957 5.548   -10.670 1.00 33.75  ? 202 PHE C CD2  1 
ATOM   2971 C  CE1  . PHE A 1 197 ? -28.789 4.283   -11.801 1.00 40.12  ? 202 PHE C CE1  1 
ATOM   2972 C  CE2  . PHE A 1 197 ? -29.883 5.164   -9.885  1.00 35.75  ? 202 PHE C CE2  1 
ATOM   2973 C  CZ   . PHE A 1 197 ? -28.804 4.532   -10.451 1.00 36.61  ? 202 PHE C CZ   1 
ATOM   2974 H  H    . PHE A 1 197 ? -33.169 8.226   -12.077 1.00 38.08  ? 202 PHE C H    1 
ATOM   2975 H  HA   . PHE A 1 197 ? -31.361 7.283   -13.993 1.00 41.07  ? 202 PHE C HA   1 
ATOM   2976 H  HB2  . PHE A 1 197 ? -32.950 5.574   -12.367 1.00 41.05  ? 202 PHE C HB2  1 
ATOM   2977 H  HB3  . PHE A 1 197 ? -32.194 5.068   -13.646 1.00 41.05  ? 202 PHE C HB3  1 
ATOM   2978 H  HD1  . PHE A 1 197 ? -29.841 4.489   -13.520 1.00 35.75  ? 202 PHE C HD1  1 
ATOM   2979 H  HD2  . PHE A 1 197 ? -31.698 5.977   -10.274 1.00 40.55  ? 202 PHE C HD2  1 
ATOM   2980 H  HE1  . PHE A 1 197 ? -28.045 3.855   -12.193 1.00 48.19  ? 202 PHE C HE1  1 
ATOM   2981 H  HE2  . PHE A 1 197 ? -29.894 5.338   -8.957  1.00 42.95  ? 202 PHE C HE2  1 
ATOM   2982 H  HZ   . PHE A 1 197 ? -28.070 4.278   -9.914  1.00 43.98  ? 202 PHE C HZ   1 
ATOM   2983 N  N    . LYS A 1 198 ? -33.077 6.963   -15.761 1.00 32.69  ? 203 LYS C N    1 
ATOM   2984 C  CA   . LYS A 1 198 ? -34.110 6.680   -16.783 1.00 33.05  ? 203 LYS C CA   1 
ATOM   2985 C  C    . LYS A 1 198 ? -34.038 5.161   -16.989 1.00 40.05  ? 203 LYS C C    1 
ATOM   2986 O  O    . LYS A 1 198 ? -32.937 4.695   -17.271 1.00 30.67  ? 203 LYS C O    1 
ATOM   2987 C  CB   . LYS A 1 198 ? -33.871 7.404   -18.102 1.00 37.37  ? 203 LYS C CB   1 
ATOM   2988 C  CG   . LYS A 1 198 ? -34.885 7.077   -19.173 1.00 48.84  ? 203 LYS C CG   1 
ATOM   2989 C  CD   . LYS A 1 198 ? -35.342 8.307   -19.941 1.00 58.48  ? 203 LYS C CD   1 
ATOM   2990 C  CE   . LYS A 1 198 ? -36.021 7.934   -21.211 1.00 63.03  ? 203 LYS C CE   1 
ATOM   2991 N  NZ   . LYS A 1 198 ? -35.142 8.196   -22.349 1.00 75.07  ? 203 LYS C NZ   1 
ATOM   2992 H  H    . LYS A 1 198 ? -32.235 7.061   -16.071 1.00 39.28  ? 203 LYS C H    1 
ATOM   2993 H  HA   . LYS A 1 198 ? -35.001 6.921   -16.430 1.00 39.71  ? 203 LYS C HA   1 
ATOM   2994 H  HB2  . LYS A 1 198 ? -33.891 8.370   -17.939 1.00 44.88  ? 203 LYS C HB2  1 
ATOM   2995 H  HB3  . LYS A 1 198 ? -32.978 7.173   -18.434 1.00 44.88  ? 203 LYS C HB3  1 
ATOM   2996 H  HG2  . LYS A 1 198 ? -34.487 6.435   -19.800 1.00 58.65  ? 203 LYS C HG2  1 
ATOM   2997 H  HG3  . LYS A 1 198 ? -35.665 6.653   -18.753 1.00 58.65  ? 203 LYS C HG3  1 
ATOM   2998 H  HD2  . LYS A 1 198 ? -35.961 8.827   -19.383 1.00 70.22  ? 203 LYS C HD2  1 
ATOM   2999 H  HD3  . LYS A 1 198 ? -34.562 8.866   -20.145 1.00 70.22  ? 203 LYS C HD3  1 
ATOM   3000 H  HE2  . LYS A 1 198 ? -36.245 6.986   -21.191 1.00 75.68  ? 203 LYS C HE2  1 
ATOM   3001 H  HE3  . LYS A 1 198 ? -36.845 8.445   -21.314 1.00 75.68  ? 203 LYS C HE3  1 
ATOM   3002 H  HZ1  . LYS A 1 198 ? -35.485 7.814   -23.095 1.00 90.13  ? 203 LYS C HZ1  1 
ATOM   3003 H  HZ2  . LYS A 1 198 ? -35.065 9.089   -22.477 1.00 90.13  ? 203 LYS C HZ2  1 
ATOM   3004 H  HZ3  . LYS A 1 198 ? -34.322 7.846   -22.183 1.00 90.13  ? 203 LYS C HZ3  1 
ATOM   3005 N  N    . ILE A 1 199 ? -35.128 4.429   -16.798 1.00 23.95  ? 204 ILE C N    1 
ATOM   3006 C  CA   . ILE A 1 199 ? -35.100 2.941   -16.853 1.00 32.16  ? 204 ILE C CA   1 
ATOM   3007 C  C    . ILE A 1 199 ? -36.207 2.421   -17.777 1.00 36.91  ? 204 ILE C C    1 
ATOM   3008 O  O    . ILE A 1 199 ? -37.358 2.815   -17.571 1.00 31.47  ? 204 ILE C O    1 
ATOM   3009 C  CB   . ILE A 1 199 ? -35.201 2.348   -15.436 1.00 30.59  ? 204 ILE C CB   1 
ATOM   3010 C  CG1  . ILE A 1 199 ? -33.966 2.662   -14.593 1.00 35.68  ? 204 ILE C CG1  1 
ATOM   3011 C  CG2  . ILE A 1 199 ? -35.462 0.844   -15.497 1.00 39.15  ? 204 ILE C CG2  1 
ATOM   3012 C  CD1  . ILE A 1 199 ? -34.211 2.625   -13.098 1.00 42.86  ? 204 ILE C CD1  1 
ATOM   3013 H  H    . ILE A 1 199 ? -35.929 4.804   -16.627 1.00 28.78  ? 204 ILE C H    1 
ATOM   3014 H  HA   . ILE A 1 199 ? -34.246 2.660   -17.228 1.00 38.63  ? 204 ILE C HA   1 
ATOM   3015 H  HB   . ILE A 1 199 ? -35.968 2.766   -14.998 1.00 36.75  ? 204 ILE C HB   1 
ATOM   3016 H  HG12 . ILE A 1 199 ? -33.265 2.014   -14.813 1.00 42.86  ? 204 ILE C HG12 1 
ATOM   3017 H  HG13 . ILE A 1 199 ? -33.634 3.550   -14.830 1.00 42.86  ? 204 ILE C HG13 1 
ATOM   3018 H  HG21 . ILE A 1 199 ? -35.172 0.431   -14.667 1.00 47.03  ? 204 ILE C HG21 1 
ATOM   3019 H  HG22 . ILE A 1 199 ? -36.413 0.681   -15.622 1.00 47.03  ? 204 ILE C HG22 1 
ATOM   3020 H  HG23 . ILE A 1 199 ? -34.967 0.457   -16.239 1.00 47.03  ? 204 ILE C HG23 1 
ATOM   3021 H  HD11 . ILE A 1 199 ? -33.522 3.147   -12.642 1.00 51.48  ? 204 ILE C HD11 1 
ATOM   3022 H  HD12 . ILE A 1 199 ? -35.088 3.008   -12.905 1.00 51.48  ? 204 ILE C HD12 1 
ATOM   3023 H  HD13 . ILE A 1 199 ? -34.181 1.703   -12.781 1.00 51.48  ? 204 ILE C HD13 1 
ATOM   3024 N  N    . HIS A 1 200 ? -35.855 1.569   -18.737 1.00 31.77  ? 205 HIS C N    1 
ATOM   3025 C  CA   . HIS A 1 200 ? -36.816 0.915   -19.655 1.00 31.28  ? 205 HIS C CA   1 
ATOM   3026 C  C    . HIS A 1 200 ? -36.808 -0.582  -19.353 1.00 33.46  ? 205 HIS C C    1 
ATOM   3027 O  O    . HIS A 1 200 ? -35.758 -1.189  -19.543 1.00 30.49  ? 205 HIS C O    1 
ATOM   3028 C  CB   . HIS A 1 200 ? -36.458 1.201   -21.116 1.00 30.84  ? 205 HIS C CB   1 
ATOM   3029 C  CG   . HIS A 1 200 ? -37.270 0.447   -22.111 1.00 34.46  ? 205 HIS C CG   1 
ATOM   3030 N  ND1  . HIS A 1 200 ? -38.607 0.163   -21.951 1.00 39.58  ? 205 HIS C ND1  1 
ATOM   3031 C  CD2  . HIS A 1 200 ? -36.922 -0.073  -23.286 1.00 33.71  ? 205 HIS C CD2  1 
ATOM   3032 C  CE1  . HIS A 1 200 ? -39.036 -0.512  -23.002 1.00 31.88  ? 205 HIS C CE1  1 
ATOM   3033 N  NE2  . HIS A 1 200 ? -38.031 -0.665  -23.826 1.00 34.79  ? 205 HIS C NE2  1 
ATOM   3034 H  H    . HIS A 1 200 ? -34.998 1.329   -18.874 1.00 38.17  ? 205 HIS C H    1 
ATOM   3035 H  HA   . HIS A 1 200 ? -37.721 1.263   -19.481 1.00 37.57  ? 205 HIS C HA   1 
ATOM   3036 H  HB2  . HIS A 1 200 ? -36.568 2.162   -21.281 1.00 37.06  ? 205 HIS C HB2  1 
ATOM   3037 H  HB3  . HIS A 1 200 ? -35.510 0.984   -21.253 1.00 37.06  ? 205 HIS C HB3  1 
ATOM   3038 H  HD1  . HIS A 1 200 ? -39.099 0.391   -21.259 1.00 47.54  ? 205 HIS C HD1  1 
ATOM   3039 H  HD2  . HIS A 1 200 ? -36.071 -0.046  -23.677 1.00 40.49  ? 205 HIS C HD2  1 
ATOM   3040 H  HE1  . HIS A 1 200 ? -39.913 -0.827  -23.132 1.00 38.30  ? 205 HIS C HE1  1 
ATOM   3041 N  N    . LEU A 1 201 ? -37.921 -1.134  -18.875 1.00 31.32  ? 206 LEU C N    1 
ATOM   3042 C  CA   . LEU A 1 201 ? -38.047 -2.593  -18.622 1.00 36.18  ? 206 LEU C CA   1 
ATOM   3043 C  C    . LEU A 1 201 ? -38.485 -3.268  -19.930 1.00 35.05  ? 206 LEU C C    1 
ATOM   3044 O  O    . LEU A 1 201 ? -39.584 -2.979  -20.398 1.00 34.38  ? 206 LEU C O    1 
ATOM   3045 C  CB   . LEU A 1 201 ? -39.015 -2.869  -17.477 1.00 34.81  ? 206 LEU C CB   1 
ATOM   3046 C  CG   . LEU A 1 201 ? -39.370 -4.333  -17.208 1.00 41.41  ? 206 LEU C CG   1 
ATOM   3047 C  CD1  . LEU A 1 201 ? -38.142 -5.147  -16.884 1.00 36.97  ? 206 LEU C CD1  1 
ATOM   3048 C  CD2  . LEU A 1 201 ? -40.385 -4.424  -16.088 1.00 35.70  ? 206 LEU C CD2  1 
ATOM   3049 H  H    . LEU A 1 201 ? -38.649 -0.637  -18.686 1.00 37.63  ? 206 LEU C H    1 
ATOM   3050 H  HA   . LEU A 1 201 ? -37.155 -2.945  -18.375 1.00 43.46  ? 206 LEU C HA   1 
ATOM   3051 H  HB2  . LEU A 1 201 ? -38.626 -2.491  -16.655 1.00 41.82  ? 206 LEU C HB2  1 
ATOM   3052 H  HB3  . LEU A 1 201 ? -39.849 -2.377  -17.658 1.00 41.82  ? 206 LEU C HB3  1 
ATOM   3053 H  HG   . LEU A 1 201 ? -39.786 -4.711  -18.025 1.00 49.74  ? 206 LEU C HG   1 
ATOM   3054 H  HD11 . LEU A 1 201 ? -38.393 -5.909  -16.336 1.00 44.40  ? 206 LEU C HD11 1 
ATOM   3055 H  HD12 . LEU A 1 201 ? -37.735 -5.463  -17.709 1.00 44.40  ? 206 LEU C HD12 1 
ATOM   3056 H  HD13 . LEU A 1 201 ? -37.504 -4.595  -16.400 1.00 44.40  ? 206 LEU C HD13 1 
ATOM   3057 H  HD21 . LEU A 1 201 ? -40.722 -5.334  -16.028 1.00 42.88  ? 206 LEU C HD21 1 
ATOM   3058 H  HD22 . LEU A 1 201 ? -39.963 -4.179  -15.247 1.00 42.88  ? 206 LEU C HD22 1 
ATOM   3059 H  HD23 . LEU A 1 201 ? -41.123 -3.817  -16.269 1.00 42.88  ? 206 LEU C HD23 1 
ATOM   3060 N  N    . ILE A 1 202 ? -37.633 -4.104  -20.499 1.00 36.23  ? 207 ILE C N    1 
ATOM   3061 C  CA   . ILE A 1 202 ? -37.922 -4.804  -21.781 1.00 39.93  ? 207 ILE C CA   1 
ATOM   3062 C  C    . ILE A 1 202 ? -38.699 -6.091  -21.497 1.00 41.68  ? 207 ILE C C    1 
ATOM   3063 O  O    . ILE A 1 202 ? -39.751 -6.249  -22.110 1.00 37.72  ? 207 ILE C O    1 
ATOM   3064 C  CB   . ILE A 1 202 ? -36.615 -5.096  -22.532 1.00 39.38  ? 207 ILE C CB   1 
ATOM   3065 C  CG1  . ILE A 1 202 ? -35.983 -3.819  -23.060 1.00 36.82  ? 207 ILE C CG1  1 
ATOM   3066 C  CG2  . ILE A 1 202 ? -36.825 -6.123  -23.644 1.00 39.69  ? 207 ILE C CG2  1 
ATOM   3067 C  CD1  . ILE A 1 202 ? -34.593 -3.565  -22.517 1.00 43.58  ? 207 ILE C CD1  1 
ATOM   3068 H  H    . ILE A 1 202 ? -36.829 -4.284  -20.130 1.00 43.52  ? 207 ILE C H    1 
ATOM   3069 H  HA   . ILE A 1 202 ? -38.472 -4.223  -22.338 1.00 47.95  ? 207 ILE C HA   1 
ATOM   3070 H  HB   . ILE A 1 202 ? -35.991 -5.483  -21.889 1.00 47.30  ? 207 ILE C HB   1 
ATOM   3071 H  HG12 . ILE A 1 202 ? -35.939 -3.869  -24.035 1.00 44.23  ? 207 ILE C HG12 1 
ATOM   3072 H  HG13 . ILE A 1 202 ? -36.558 -3.062  -22.823 1.00 44.23  ? 207 ILE C HG13 1 
ATOM   3073 H  HG21 . ILE A 1 202 ? -36.100 -6.055  -24.287 1.00 47.67  ? 207 ILE C HG21 1 
ATOM   3074 H  HG22 . ILE A 1 202 ? -36.835 -7.019  -23.266 1.00 47.67  ? 207 ILE C HG22 1 
ATOM   3075 H  HG23 . ILE A 1 202 ? -37.669 -5.951  -24.093 1.00 47.67  ? 207 ILE C HG23 1 
ATOM   3076 H  HD11 . ILE A 1 202 ? -34.174 -2.836  -23.011 1.00 52.34  ? 207 ILE C HD11 1 
ATOM   3077 H  HD12 . ILE A 1 202 ? -34.664 -3.319  -21.576 1.00 52.34  ? 207 ILE C HD12 1 
ATOM   3078 H  HD13 . ILE A 1 202 ? -34.049 -4.371  -22.601 1.00 52.34  ? 207 ILE C HD13 1 
ATOM   3079 N  N    . SER A 1 203 ? -38.208 -6.948  -20.604 1.00 38.62  ? 208 SER C N    1 
ATOM   3080 C  CA   . SER A 1 203 ? -38.821 -8.278  -20.369 1.00 37.60  ? 208 SER C CA   1 
ATOM   3081 C  C    . SER A 1 203 ? -38.602 -8.771  -18.943 1.00 40.51  ? 208 SER C C    1 
ATOM   3082 O  O    . SER A 1 203 ? -37.616 -8.346  -18.329 1.00 39.18  ? 208 SER C O    1 
ATOM   3083 C  CB   . SER A 1 203 ? -38.258 -9.288  -21.329 1.00 50.40  ? 208 SER C CB   1 
ATOM   3084 O  OG   . SER A 1 203 ? -36.855 -9.424  -21.169 1.00 42.32  ? 208 SER C OG   1 
ATOM   3085 H  H    . SER A 1 203 ? -37.477 -6.750  -20.113 1.00 46.39  ? 208 SER C H    1 
ATOM   3086 H  HA   . SER A 1 203 ? -39.795 -8.207  -20.521 1.00 45.17  ? 208 SER C HA   1 
ATOM   3087 H  HB2  . SER A 1 203 ? -38.687 -10.150 -21.174 1.00 60.52  ? 208 SER C HB2  1 
ATOM   3088 H  HB3  . SER A 1 203 ? -38.457 -9.009  -22.243 1.00 60.52  ? 208 SER C HB3  1 
ATOM   3089 H  HG   . SER A 1 203 ? -36.467 -8.851  -21.657 1.00 50.83  ? 208 SER C HG   1 
ATOM   3090 N  N    . VAL A 1 204 ? -39.477 -9.660  -18.482 1.00 45.21  ? 209 VAL C N    1 
ATOM   3091 C  CA   . VAL A 1 204 ? -39.382 -10.263 -17.126 1.00 45.87  ? 209 VAL C CA   1 
ATOM   3092 C  C    . VAL A 1 204 ? -39.536 -11.783 -17.280 1.00 56.39  ? 209 VAL C C    1 
ATOM   3093 O  O    . VAL A 1 204 ? -40.347 -12.206 -18.122 1.00 49.80  ? 209 VAL C O    1 
ATOM   3094 C  CB   . VAL A 1 204 ? -40.401 -9.667  -16.137 1.00 49.21  ? 209 VAL C CB   1 
ATOM   3095 C  CG1  . VAL A 1 204 ? -40.903 -8.289  -16.547 1.00 45.87  ? 209 VAL C CG1  1 
ATOM   3096 C  CG2  . VAL A 1 204 ? -41.562 -10.603 -15.852 1.00 64.94  ? 209 VAL C CG2  1 
ATOM   3097 H  H    . VAL A 1 204 ? -40.181 -9.928  -18.977 1.00 54.30  ? 209 VAL C H    1 
ATOM   3098 H  HA   . VAL A 1 204 ? -38.488 -10.088 -16.777 1.00 55.09  ? 209 VAL C HA   1 
ATOM   3099 H  HB   . VAL A 1 204 ? -39.923 -9.543  -15.283 1.00 59.10  ? 209 VAL C HB   1 
ATOM   3100 H  HG11 . VAL A 1 204 ? -41.416 -7.901  -15.817 1.00 55.09  ? 209 VAL C HG11 1 
ATOM   3101 H  HG12 . VAL A 1 204 ? -40.147 -7.711  -16.749 1.00 55.09  ? 209 VAL C HG12 1 
ATOM   3102 H  HG13 . VAL A 1 204 ? -41.472 -8.368  -17.331 1.00 55.09  ? 209 VAL C HG13 1 
ATOM   3103 H  HG21 . VAL A 1 204 ? -42.253 -10.113 -15.379 1.00 77.97  ? 209 VAL C HG21 1 
ATOM   3104 H  HG22 . VAL A 1 204 ? -41.919 -10.943 -16.689 1.00 77.97  ? 209 VAL C HG22 1 
ATOM   3105 H  HG23 . VAL A 1 204 ? -41.260 -11.345 -15.298 1.00 77.97  ? 209 VAL C HG23 1 
ATOM   3106 N  N    . LYS A 1 205 ? -38.767 -12.560 -16.518 1.00 59.52  ? 210 LYS C N    1 
ATOM   3107 C  CA   . LYS A 1 205 ? -38.794 -14.042 -16.565 1.00 54.26  ? 210 LYS C CA   1 
ATOM   3108 C  C    . LYS A 1 205 ? -38.754 -14.576 -15.136 1.00 55.47  ? 210 LYS C C    1 
ATOM   3109 O  O    . LYS A 1 205 ? -38.018 -14.015 -14.315 1.00 55.34  ? 210 LYS C O    1 
ATOM   3110 C  CB   . LYS A 1 205 ? -37.601 -14.604 -17.335 1.00 49.99  ? 210 LYS C CB   1 
ATOM   3111 C  CG   . LYS A 1 205 ? -36.232 -14.260 -16.781 1.00 55.14  ? 210 LYS C CG   1 
ATOM   3112 C  CD   . LYS A 1 205 ? -35.146 -14.255 -17.844 1.00 66.18  ? 210 LYS C CD   1 
ATOM   3113 C  CE   . LYS A 1 205 ? -34.695 -15.630 -18.180 1.00 65.75  ? 210 LYS C CE   1 
ATOM   3114 N  NZ   . LYS A 1 205 ? -33.831 -15.601 -19.358 1.00 80.21  ? 210 LYS C NZ   1 
ATOM   3115 H  H    . LYS A 1 205 ? -38.189 -12.207 -15.922 1.00 71.47  ? 210 LYS C H    1 
ATOM   3116 H  HA   . LYS A 1 205 ? -39.635 -14.339 -16.991 1.00 65.15  ? 210 LYS C HA   1 
ATOM   3117 H  HB2  . LYS A 1 205 ? -37.684 -15.581 -17.361 1.00 60.03  ? 210 LYS C HB2  1 
ATOM   3118 H  HB3  . LYS A 1 205 ? -37.649 -14.279 -18.258 1.00 60.03  ? 210 LYS C HB3  1 
ATOM   3119 H  HG2  . LYS A 1 205 ? -36.271 -13.375 -16.360 1.00 66.21  ? 210 LYS C HG2  1 
ATOM   3120 H  HG3  . LYS A 1 205 ? -35.997 -14.915 -16.089 1.00 66.21  ? 210 LYS C HG3  1 
ATOM   3121 H  HD2  . LYS A 1 205 ? -35.489 -13.823 -18.654 1.00 79.46  ? 210 LYS C HD2  1 
ATOM   3122 H  HD3  . LYS A 1 205 ? -34.379 -13.737 -17.520 1.00 79.46  ? 210 LYS C HD3  1 
ATOM   3123 H  HE2  . LYS A 1 205 ? -34.204 -16.004 -17.428 1.00 78.94  ? 210 LYS C HE2  1 
ATOM   3124 H  HE3  . LYS A 1 205 ? -35.466 -16.196 -18.361 1.00 78.94  ? 210 LYS C HE3  1 
ATOM   3125 H  HZ1  . LYS A 1 205 ? -33.501 -16.429 -19.519 1.00 96.30  ? 210 LYS C HZ1  1 
ATOM   3126 H  HZ2  . LYS A 1 205 ? -34.310 -15.321 -20.074 1.00 96.30  ? 210 LYS C HZ2  1 
ATOM   3127 H  HZ3  . LYS A 1 205 ? -33.147 -15.025 -19.212 1.00 96.30  ? 210 LYS C HZ3  1 
ATOM   3128 N  N    . LYS A 1 206 ? -39.508 -15.631 -14.865 1.00 56.60  ? 211 LYS C N    1 
ATOM   3129 C  CA   . LYS A 1 206 ? -39.573 -16.221 -13.511 1.00 62.46  ? 211 LYS C CA   1 
ATOM   3130 C  C    . LYS A 1 206 ? -38.332 -17.083 -13.273 1.00 66.37  ? 211 LYS C C    1 
ATOM   3131 O  O    . LYS A 1 206 ? -37.501 -17.182 -14.192 1.00 60.24  ? 211 LYS C O    1 
ATOM   3132 C  CB   . LYS A 1 206 ? -40.855 -17.040 -13.371 1.00 68.02  ? 211 LYS C CB   1 
ATOM   3133 C  CG   . LYS A 1 206 ? -42.152 -16.271 -13.531 1.00 58.14  ? 211 LYS C CG   1 
ATOM   3134 C  CD   . LYS A 1 206 ? -42.622 -15.611 -12.245 1.00 61.66  ? 211 LYS C CD   1 
ATOM   3135 C  CE   . LYS A 1 206 ? -43.125 -14.241 -12.516 1.00 66.01  ? 211 LYS C CE   1 
ATOM   3136 N  NZ   . LYS A 1 206 ? -43.507 -13.565 -11.278 1.00 62.15  ? 211 LYS C NZ   1 
ATOM   3137 H  H    . LYS A 1 206 ? -40.004 -16.033 -15.502 1.00 67.96  ? 211 LYS C H    1 
ATOM   3138 H  HA   . LYS A 1 206 ? -39.589 -15.489 -12.846 1.00 75.00  ? 211 LYS C HA   1 
ATOM   3139 H  HB2  . LYS A 1 206 ? -40.837 -17.756 -14.040 1.00 81.66  ? 211 LYS C HB2  1 
ATOM   3140 H  HB3  . LYS A 1 206 ? -40.860 -17.462 -12.486 1.00 81.66  ? 211 LYS C HB3  1 
ATOM   3141 H  HG2  . LYS A 1 206 ? -42.029 -15.582 -14.217 1.00 69.81  ? 211 LYS C HG2  1 
ATOM   3142 H  HG3  . LYS A 1 206 ? -42.846 -16.889 -13.845 1.00 69.81  ? 211 LYS C HG3  1 
ATOM   3143 H  HD2  . LYS A 1 206 ? -43.339 -16.146 -11.844 1.00 74.04  ? 211 LYS C HD2  1 
ATOM   3144 H  HD3  . LYS A 1 206 ? -41.875 -15.565 -11.612 1.00 74.04  ? 211 LYS C HD3  1 
ATOM   3145 H  HE2  . LYS A 1 206 ? -42.430 -13.728 -12.964 1.00 79.25  ? 211 LYS C HE2  1 
ATOM   3146 H  HE3  . LYS A 1 206 ? -43.897 -14.291 -13.106 1.00 79.25  ? 211 LYS C HE3  1 
ATOM   3147 H  HZ1  . LYS A 1 206 ? -43.577 -12.674 -11.426 1.00 74.62  ? 211 LYS C HZ1  1 
ATOM   3148 H  HZ2  . LYS A 1 206 ? -44.300 -13.888 -10.986 1.00 74.62  ? 211 LYS C HZ2  1 
ATOM   3149 H  HZ3  . LYS A 1 206 ? -42.872 -13.715 -10.650 1.00 74.62  ? 211 LYS C HZ3  1 
ATOM   3150 N  N    . SER A 1 207 ? -38.219 -17.672 -12.086 1.00 79.66  ? 212 SER C N    1 
ATOM   3151 C  CA   . SER A 1 207 ? -37.057 -18.516 -11.711 1.00 87.67  ? 212 SER C CA   1 
ATOM   3152 C  C    . SER A 1 207 ? -37.347 -19.996 -11.980 1.00 88.45  ? 212 SER C C    1 
ATOM   3153 O  O    . SER A 1 207 ? -36.575 -20.609 -12.741 1.00 87.00  ? 212 SER C O    1 
ATOM   3154 C  CB   . SER A 1 207 ? -36.726 -18.298 -10.271 1.00 83.24  ? 212 SER C CB   1 
ATOM   3155 O  OG   . SER A 1 207 ? -37.846 -18.565 -9.438  1.00 85.53  ? 212 SER C OG   1 
ATOM   3156 H  H    . SER A 1 207 ? -38.849 -17.574 -11.448 1.00 95.64  ? 212 SER C H    1 
ATOM   3157 H  HA   . SER A 1 207 ? -36.278 -18.244 -12.255 1.00 105.24 ? 212 SER C HA   1 
ATOM   3158 H  HB2  . SER A 1 207 ? -35.989 -18.885 -10.019 1.00 99.93  ? 212 SER C HB2  1 
ATOM   3159 H  HB3  . SER A 1 207 ? -36.438 -17.374 -10.144 1.00 99.93  ? 212 SER C HB3  1 
ATOM   3160 H  HG   . SER A 1 207 ? -38.279 -17.849 -9.315  1.00 102.68 ? 212 SER C HG   1 
ATOM   3161 N  N    . SER A 1 208 ? -38.416 -20.540 -11.401 1.00 93.48  ? 213 SER C N    1 
ATOM   3162 C  CA   . SER A 1 208 ? -38.749 -21.985 -11.506 1.00 94.63  ? 213 SER C CA   1 
ATOM   3163 C  C    . SER A 1 208 ? -39.564 -22.291 -12.772 1.00 95.41  ? 213 SER C C    1 
ATOM   3164 O  O    . SER A 1 208 ? -40.125 -23.381 -12.871 1.00 90.78  ? 213 SER C O    1 
ATOM   3165 C  CB   . SER A 1 208 ? -39.492 -22.403 -10.277 1.00 91.16  ? 213 SER C CB   1 
ATOM   3166 O  OG   . SER A 1 208 ? -39.015 -21.696 -9.139  1.00 94.75  ? 213 SER C OG   1 
ATOM   3167 O  OXT  . SER A 1 208 ? -39.620 -21.417 -13.644 1.00 103.37 ? 213 SER C OXT  1 
ATOM   3168 H  H    . SER A 1 208 ? -38.989 -20.042 -10.913 1.00 112.22 ? 213 SER C H    1 
ATOM   3169 H  HA   . SER A 1 208 ? -37.904 -22.498 -11.548 1.00 113.60 ? 213 SER C HA   1 
ATOM   3170 H  HB2  . SER A 1 208 ? -40.443 -22.221 -10.398 1.00 109.44 ? 213 SER C HB2  1 
ATOM   3171 H  HB3  . SER A 1 208 ? -39.377 -23.361 -10.138 1.00 109.44 ? 213 SER C HB3  1 
ATOM   3172 H  HG   . SER A 1 208 ? -39.606 -21.718 -8.536  1.00 113.74 ? 213 SER C HG   1 
HETATM 3173 C  C1   . GOL B 2 .   ? -28.172 -0.432  -10.280 1.00 50.25  ? 301 GOL C C1   1 
HETATM 3174 O  O1   . GOL B 2 .   ? -28.607 -1.274  -9.142  1.00 47.69  ? 301 GOL C O1   1 
HETATM 3175 C  C2   . GOL B 2 .   ? -27.105 -1.268  -10.974 1.00 46.80  ? 301 GOL C C2   1 
HETATM 3176 O  O2   . GOL B 2 .   ? -27.592 -2.047  -11.989 1.00 62.12  ? 301 GOL C O2   1 
HETATM 3177 C  C3   . GOL B 2 .   ? -26.108 -0.389  -11.510 1.00 53.60  ? 301 GOL C C3   1 
HETATM 3178 O  O3   . GOL B 2 .   ? -25.120 -1.282  -12.072 1.00 66.98  ? 301 GOL C O3   1 
HETATM 3179 H  H11  . GOL B 2 .   ? -27.803 0.421   -10.006 1.00 60.34  ? 301 GOL C H11  1 
HETATM 3180 H  H12  . GOL B 2 .   ? -28.890 -0.225  -10.899 1.00 60.34  ? 301 GOL C H12  1 
HETATM 3181 H  HO1  . GOL B 2 .   ? -27.969 -1.268  -8.575  1.00 57.27  ? 301 GOL C HO1  1 
HETATM 3182 H  H2   . GOL B 2 .   ? -26.739 -1.846  -10.287 1.00 56.21  ? 301 GOL C H2   1 
HETATM 3183 H  HO2  . GOL B 2 .   ? -27.150 -1.855  -12.697 1.00 74.58  ? 301 GOL C HO2  1 
HETATM 3184 H  H31  . GOL B 2 .   ? -25.766 0.186   -10.807 1.00 64.36  ? 301 GOL C H31  1 
HETATM 3185 H  H32  . GOL B 2 .   ? -26.512 0.210   -12.157 1.00 64.36  ? 301 GOL C H32  1 
HETATM 3186 H  HO3  . GOL B 2 .   ? -24.474 -0.802  -12.343 1.00 80.42  ? 301 GOL C HO3  1 
HETATM 3187 C  C1   . GOL C 2 .   ? -25.759 -2.169  -3.420  1.00 70.14  ? 302 GOL C C1   1 
HETATM 3188 O  O1   . GOL C 2 .   ? -26.467 -1.745  -2.255  1.00 74.43  ? 302 GOL C O1   1 
HETATM 3189 C  C2   . GOL C 2 .   ? -26.596 -3.270  -4.141  1.00 59.47  ? 302 GOL C C2   1 
HETATM 3190 O  O2   . GOL C 2 .   ? -26.013 -3.637  -5.373  1.00 69.90  ? 302 GOL C O2   1 
HETATM 3191 C  C3   . GOL C 2 .   ? -26.656 -4.423  -3.175  1.00 68.23  ? 302 GOL C C3   1 
HETATM 3192 O  O3   . GOL C 2 .   ? -26.218 -5.533  -3.897  1.00 75.68  ? 302 GOL C O3   1 
HETATM 3193 H  H11  . GOL C 2 .   ? -24.885 -2.530  -3.208  1.00 84.21  ? 302 GOL C H11  1 
HETATM 3194 H  H12  . GOL C 2 .   ? -25.602 -1.439  -4.040  1.00 84.21  ? 302 GOL C H12  1 
HETATM 3195 H  HO1  . GOL C 2 .   ? -26.074 -1.047  -1.965  1.00 89.37  ? 302 GOL C HO1  1 
HETATM 3196 H  H2   . GOL C 2 .   ? -27.488 -2.945  -4.340  1.00 71.41  ? 302 GOL C H2   1 
HETATM 3197 H  HO2  . GOL C 2 .   ? -25.756 -4.444  -5.314  1.00 83.92  ? 302 GOL C HO2  1 
HETATM 3198 H  H31  . GOL C 2 .   ? -27.560 -4.511  -2.835  1.00 81.92  ? 302 GOL C H31  1 
HETATM 3199 H  H32  . GOL C 2 .   ? -26.109 -4.222  -2.400  1.00 81.92  ? 302 GOL C H32  1 
HETATM 3200 H  HO3  . GOL C 2 .   ? -26.129 -6.172  -3.340  1.00 90.86  ? 302 GOL C HO3  1 
HETATM 3201 O  O1   . MES D 3 .   ? -36.813 -5.532  -1.233  1.00 67.32  ? 303 MES C O1   1 
HETATM 3202 C  C2   . MES D 3 .   ? -37.713 -6.395  -0.565  1.00 47.42  ? 303 MES C C2   1 
HETATM 3203 C  C3   . MES D 3 .   ? -39.133 -5.984  -0.811  1.00 31.74  ? 303 MES C C3   1 
HETATM 3204 N  N4   . MES D 3 .   ? -39.333 -4.608  -0.285  1.00 9.00   ? 303 MES C N4   1 
HETATM 3205 C  C5   . MES D 3 .   ? -38.357 -3.699  -0.954  1.00 51.21  ? 303 MES C C5   1 
HETATM 3206 C  C6   . MES D 3 .   ? -36.956 -4.208  -0.746  1.00 54.78  ? 303 MES C C6   1 
HETATM 3207 C  C7   . MES D 3 .   ? -40.748 -4.151  -0.474  1.00 38.10  ? 303 MES C C7   1 
HETATM 3208 C  C8   . MES D 3 .   ? -41.249 -3.244  0.642   1.00 19.77  ? 303 MES C C8   1 
HETATM 3209 S  S    . MES D 3 .   ? -41.057 -1.500  0.346   1.00 19.97  ? 303 MES C S    1 
HETATM 3210 O  O1S  . MES D 3 .   ? -40.721 -1.398  -1.025  1.00 61.02  ? 303 MES C O1S  1 
HETATM 3211 O  O2S  . MES D 3 .   ? -42.308 -0.878  0.627   1.00 26.32  ? 303 MES C O2S  1 
HETATM 3212 O  O3S  . MES D 3 .   ? -40.038 -1.063  1.229   1.00 56.14  ? 303 MES C O3S  1 
HETATM 3213 H  H21  . MES D 3 .   ? -37.532 -6.365  0.391   1.00 56.95  ? 303 MES C H21  1 
HETATM 3214 H  H22  . MES D 3 .   ? -37.578 -7.309  -0.877  1.00 56.95  ? 303 MES C H22  1 
HETATM 3215 H  H31  . MES D 3 .   ? -39.744 -6.592  -0.361  1.00 38.13  ? 303 MES C H31  1 
HETATM 3216 H  H32  . MES D 3 .   ? -39.325 -5.990  -1.766  1.00 38.13  ? 303 MES C H32  1 
HETATM 3217 H  HN4  . MES D 3 .   ? -39.149 -4.615  0.607   1.00 10.85  ? 303 MES C HN4  1 
HETATM 3218 H  H51  . MES D 3 .   ? -38.561 -3.659  -1.906  1.00 61.49  ? 303 MES C H51  1 
HETATM 3219 H  H52  . MES D 3 .   ? -38.446 -2.807  -0.577  1.00 61.49  ? 303 MES C H52  1 
HETATM 3220 H  H61  . MES D 3 .   ? -36.329 -3.625  -1.211  1.00 65.78  ? 303 MES C H61  1 
HETATM 3221 H  H62  . MES D 3 .   ? -36.744 -4.191  0.205   1.00 65.78  ? 303 MES C H62  1 
HETATM 3222 H  H71  . MES D 3 .   ? -41.320 -4.991  -0.507  1.00 45.76  ? 303 MES C H71  1 
HETATM 3223 H  H72  . MES D 3 .   ? -40.806 -3.711  -1.386  1.00 45.76  ? 303 MES C H72  1 
HETATM 3224 H  H81  . MES D 3 .   ? -42.196 -3.403  0.802   1.00 23.77  ? 303 MES C H81  1 
HETATM 3225 H  H82  . MES D 3 .   ? -40.778 -3.445  1.471   1.00 23.77  ? 303 MES C H82  1 
HETATM 3226 C  C1   . PEG E 4 .   ? -33.370 -6.423  -0.302  1.00 67.91  ? 304 PEG C C1   1 
HETATM 3227 O  O1   . PEG E 4 .   ? -34.057 -5.280  -0.771  1.00 55.04  ? 304 PEG C O1   1 
HETATM 3228 C  C2   . PEG E 4 .   ? -34.302 -7.571  -0.038  1.00 68.87  ? 304 PEG C C2   1 
HETATM 3229 O  O2   . PEG E 4 .   ? -35.036 -7.315  1.153   1.00 68.94  ? 304 PEG C O2   1 
HETATM 3230 C  C3   . PEG E 4 .   ? -35.380 -8.500  1.856   1.00 62.20  ? 304 PEG C C3   1 
HETATM 3231 C  C4   . PEG E 4 .   ? -36.725 -8.962  1.379   1.00 63.79  ? 304 PEG C C4   1 
HETATM 3232 O  O4   . PEG E 4 .   ? -37.307 -9.984  2.192   1.00 60.22  ? 304 PEG C O4   1 
HETATM 3233 H  H11  . PEG E 4 .   ? -32.910 -6.196  0.521   1.00 81.53  ? 304 PEG C H11  1 
HETATM 3234 H  H12  . PEG E 4 .   ? -32.721 -6.694  -0.971  1.00 81.53  ? 304 PEG C H12  1 
HETATM 3235 H  HO1  . PEG E 4 .   ? -33.551 -4.614  -0.917  1.00 66.09  ? 304 PEG C HO1  1 
HETATM 3236 H  H21  . PEG E 4 .   ? -33.789 -8.388  0.067   1.00 82.69  ? 304 PEG C H21  1 
HETATM 3237 H  H22  . PEG E 4 .   ? -34.916 -7.668  -0.783  1.00 82.69  ? 304 PEG C H22  1 
HETATM 3238 H  H31  . PEG E 4 .   ? -34.718 -9.188  1.683   1.00 74.68  ? 304 PEG C H31  1 
HETATM 3239 H  H32  . PEG E 4 .   ? -35.416 -8.317  2.808   1.00 74.68  ? 304 PEG C H32  1 
HETATM 3240 H  H41  . PEG E 4 .   ? -37.324 -8.199  1.370   1.00 76.59  ? 304 PEG C H41  1 
HETATM 3241 H  H42  . PEG E 4 .   ? -36.627 -9.306  0.477   1.00 76.59  ? 304 PEG C H42  1 
HETATM 3242 H  HO4  . PEG E 4 .   ? -38.132 -10.118 2.028   1.00 72.31  ? 304 PEG C HO4  1 
HETATM 3243 C  C1   . PEG F 4 .   ? 19.827  6.618   -20.693 1.00 82.06  ? 305 PEG C C1   1 
HETATM 3244 O  O1   . PEG F 4 .   ? 19.170  7.403   -21.679 1.00 67.61  ? 305 PEG C O1   1 
HETATM 3245 C  C2   . PEG F 4 .   ? 19.361  5.199   -20.721 1.00 79.81  ? 305 PEG C C2   1 
HETATM 3246 O  O2   . PEG F 4 .   ? 19.482  4.648   -19.421 1.00 83.49  ? 305 PEG C O2   1 
HETATM 3247 C  C3   . PEG F 4 .   ? 20.543  3.720   -19.322 1.00 90.12  ? 305 PEG C C3   1 
HETATM 3248 C  C4   . PEG F 4 .   ? 21.844  4.456   -19.354 1.00 84.35  ? 305 PEG C C4   1 
HETATM 3249 O  O4   . PEG F 4 .   ? 22.740  3.891   -18.418 1.00 70.50  ? 305 PEG C O4   1 
HETATM 3250 H  H11  . PEG F 4 .   ? 20.782  6.639   -20.859 1.00 98.52  ? 305 PEG C H11  1 
HETATM 3251 H  H12  . PEG F 4 .   ? 19.642  6.993   -19.817 1.00 98.52  ? 305 PEG C H12  1 
HETATM 3252 H  HO1  . PEG F 4 .   ? 19.379  8.226   -21.662 1.00 81.18  ? 305 PEG C HO1  1 
HETATM 3253 H  H21  . PEG F 4 .   ? 19.905  4.690   -21.342 1.00 95.82  ? 305 PEG C H21  1 
HETATM 3254 H  H22  . PEG F 4 .   ? 18.433  5.167   -21.003 1.00 95.82  ? 305 PEG C H22  1 
HETATM 3255 H  H31  . PEG F 4 .   ? 20.469  3.229   -18.489 1.00 108.18 ? 305 PEG C H31  1 
HETATM 3256 H  H32  . PEG F 4 .   ? 20.503  3.100   -20.067 1.00 108.18 ? 305 PEG C H32  1 
HETATM 3257 H  H41  . PEG F 4 .   ? 22.227  4.395   -20.243 1.00 101.27 ? 305 PEG C H41  1 
HETATM 3258 H  H42  . PEG F 4 .   ? 21.692  5.388   -19.131 1.00 101.27 ? 305 PEG C H42  1 
HETATM 3259 H  HO4  . PEG F 4 .   ? 23.509  4.247   -18.423 1.00 84.65  ? 305 PEG C HO4  1 
HETATM 3260 C  C1   . GOL G 2 .   ? 8.138   6.497   -2.792  1.00 99.29  ? 306 GOL C C1   1 
HETATM 3261 O  O1   . GOL G 2 .   ? 7.815   6.975   -4.070  1.00 89.17  ? 306 GOL C O1   1 
HETATM 3262 C  C2   . GOL G 2 .   ? 8.494   4.993   -2.904  1.00 108.74 ? 306 GOL C C2   1 
HETATM 3263 O  O2   . GOL G 2 .   ? 9.421   4.753   -3.886  1.00 83.91  ? 306 GOL C O2   1 
HETATM 3264 C  C3   . GOL G 2 .   ? 9.053   4.588   -1.523  1.00 110.24 ? 306 GOL C C3   1 
HETATM 3265 O  O3   . GOL G 2 .   ? 7.977   4.199   -0.742  1.00 92.57  ? 306 GOL C O3   1 
HETATM 3266 H  H11  . GOL G 2 .   ? 7.405   6.600   -2.164  1.00 119.19 ? 306 GOL C H11  1 
HETATM 3267 H  H12  . GOL G 2 .   ? 8.890   6.969   -2.401  1.00 119.19 ? 306 GOL C H12  1 
HETATM 3268 H  HO1  . GOL G 2 .   ? 8.098   6.397   -4.623  1.00 107.04 ? 306 GOL C HO1  1 
HETATM 3269 H  H2   . GOL G 2 .   ? 7.695   4.491   -3.128  1.00 130.53 ? 306 GOL C H2   1 
HETATM 3270 H  HO2  . GOL G 2 .   ? 9.627   3.930   -3.854  1.00 100.73 ? 306 GOL C HO2  1 
HETATM 3271 H  H31  . GOL G 2 .   ? 9.545   5.338   -1.153  1.00 132.33 ? 306 GOL C H31  1 
HETATM 3272 H  H32  . GOL G 2 .   ? 9.711   3.886   -1.647  1.00 132.33 ? 306 GOL C H32  1 
HETATM 3273 H  HO3  . GOL G 2 .   ? 8.297   3.890   -0.021  1.00 111.13 ? 306 GOL C HO3  1 
HETATM 3274 NA NA   . NA  H 5 .   ? -36.407 14.632  -16.711 1.00 30.00  ? 307 NA  C NA   1 
HETATM 3275 O  O    . HOH I 6 .   ? -26.644 13.904  -7.036  1.00 37.06  ? 401 HOH C O    1 
HETATM 3276 O  O    . HOH I 6 .   ? -45.611 14.798  -6.286  1.00 48.43  ? 402 HOH C O    1 
HETATM 3277 O  O    . HOH I 6 .   ? -27.641 7.984   3.036   1.00 38.79  ? 403 HOH C O    1 
HETATM 3278 O  O    . HOH I 6 .   ? -41.556 -8.105  -22.608 1.00 40.95  ? 404 HOH C O    1 
HETATM 3279 O  O    . HOH I 6 .   ? -42.349 -0.713  -4.450  1.00 41.01  ? 405 HOH C O    1 
HETATM 3280 O  O    . HOH I 6 .   ? -34.704 12.525  -18.329 1.00 52.72  ? 406 HOH C O    1 
HETATM 3281 O  O    . HOH I 6 .   ? -46.149 9.867   -13.734 1.00 39.68  ? 407 HOH C O    1 
HETATM 3282 O  O    . HOH I 6 .   ? -44.420 11.173  -21.939 1.00 44.45  ? 408 HOH C O    1 
HETATM 3283 O  O    . HOH I 6 .   ? -39.027 11.942  -1.585  1.00 42.39  ? 409 HOH C O    1 
HETATM 3284 O  O    . HOH I 6 .   ? -30.601 9.410   -16.262 1.00 49.37  ? 410 HOH C O    1 
HETATM 3285 O  O    . HOH I 6 .   ? -26.009 7.145   -3.594  1.00 35.57  ? 411 HOH C O    1 
HETATM 3286 O  O    . HOH I 6 .   ? 21.104  13.284  11.970  1.00 49.95  ? 412 HOH C O    1 
HETATM 3287 O  O    . HOH I 6 .   ? -39.261 15.416  -12.589 1.00 42.34  ? 413 HOH C O    1 
HETATM 3288 O  O    . HOH I 6 .   ? -23.583 7.794   -2.072  1.00 36.38  ? 414 HOH C O    1 
HETATM 3289 O  O    . HOH I 6 .   ? -46.251 2.506   -16.209 1.00 46.62  ? 415 HOH C O    1 
HETATM 3290 O  O    . HOH I 6 .   ? -38.778 -15.774 -9.982  1.00 62.70  ? 416 HOH C O    1 
HETATM 3291 O  O    . HOH I 6 .   ? -30.037 20.804  -4.716  1.00 48.85  ? 417 HOH C O    1 
HETATM 3292 O  O    . HOH I 6 .   ? -41.762 2.797   -1.248  1.00 32.94  ? 418 HOH C O    1 
HETATM 3293 O  O    . HOH I 6 .   ? -47.546 7.091   -24.021 1.00 35.64  ? 419 HOH C O    1 
HETATM 3294 O  O    . HOH I 6 .   ? -25.090 -4.216  -21.341 1.00 61.15  ? 420 HOH C O    1 
HETATM 3295 O  O    . HOH I 6 .   ? -48.385 -7.707  -13.409 1.00 51.10  ? 421 HOH C O    1 
HETATM 3296 O  O    . HOH I 6 .   ? -41.551 2.443   -23.176 1.00 28.64  ? 422 HOH C O    1 
HETATM 3297 O  O    . HOH I 6 .   ? -48.139 3.453   -24.141 1.00 46.64  ? 423 HOH C O    1 
HETATM 3298 O  O    . HOH I 6 .   ? -27.150 14.389  -3.477  1.00 35.64  ? 424 HOH C O    1 
HETATM 3299 O  O    . HOH I 6 .   ? -45.286 -9.494  -19.786 1.00 46.76  ? 425 HOH C O    1 
HETATM 3300 O  O    . HOH I 6 .   ? -48.118 0.700   -11.692 1.00 52.16  ? 426 HOH C O    1 
HETATM 3301 O  O    . HOH I 6 .   ? -44.847 -6.922  -8.648  1.00 46.83  ? 427 HOH C O    1 
HETATM 3302 O  O    . HOH I 6 .   ? -52.059 -4.765  -19.616 1.00 54.31  ? 428 HOH C O    1 
HETATM 3303 O  O    . HOH I 6 .   ? -16.914 17.803  9.615   1.00 49.73  ? 429 HOH C O    1 
HETATM 3304 O  O    . HOH I 6 .   ? -2.142  17.503  7.789   1.00 56.64  ? 430 HOH C O    1 
HETATM 3305 O  O    . HOH I 6 .   ? -28.983 13.022  -0.591  1.00 44.98  ? 431 HOH C O    1 
HETATM 3306 O  O    . HOH I 6 .   ? 27.270  8.064   -6.896  1.00 57.06  ? 432 HOH C O    1 
HETATM 3307 O  O    . HOH I 6 .   ? -36.009 22.913  -2.319  1.00 47.37  ? 433 HOH C O    1 
HETATM 3308 O  O    . HOH I 6 .   ? -47.383 11.697  -4.714  1.00 44.00  ? 434 HOH C O    1 
HETATM 3309 O  O    . HOH I 6 .   ? -36.453 18.573  -10.195 1.00 56.54  ? 435 HOH C O    1 
HETATM 3310 O  O    . HOH I 6 .   ? -37.558 7.157   -23.875 1.00 54.83  ? 436 HOH C O    1 
HETATM 3311 O  O    . HOH I 6 .   ? -37.394 3.570   -24.134 1.00 39.70  ? 437 HOH C O    1 
HETATM 3312 O  O    . HOH I 6 .   ? -50.811 -1.140  -13.711 1.00 58.49  ? 438 HOH C O    1 
HETATM 3313 O  O    . HOH I 6 .   ? -31.614 5.280   -21.821 1.00 57.94  ? 439 HOH C O    1 
HETATM 3314 O  O    . HOH I 6 .   ? 21.402  9.554   -18.476 1.00 61.11  ? 440 HOH C O    1 
HETATM 3315 O  O    . HOH I 6 .   ? -32.165 7.820   -23.193 1.00 63.27  ? 441 HOH C O    1 
HETATM 3316 O  O    . HOH I 6 .   ? -42.090 -10.168 -20.165 1.00 47.56  ? 442 HOH C O    1 
HETATM 3317 O  O    . HOH I 6 .   ? -24.867 13.754  6.457   1.00 50.91  ? 443 HOH C O    1 
HETATM 3318 O  O    . HOH I 6 .   ? -41.405 16.661  -14.440 1.00 52.39  ? 444 HOH C O    1 
HETATM 3319 O  O    . HOH I 6 .   ? 23.662  6.054   -12.755 1.00 55.91  ? 445 HOH C O    1 
HETATM 3320 O  O    . HOH I 6 .   ? 10.754  15.843  20.440  1.00 55.83  ? 446 HOH C O    1 
HETATM 3321 O  O    . HOH I 6 .   ? -21.841 17.977  -16.310 1.00 65.83  ? 447 HOH C O    1 
HETATM 3322 O  O    . HOH I 6 .   ? -43.400 12.702  -19.251 1.00 55.06  ? 448 HOH C O    1 
HETATM 3323 O  O    . HOH I 6 .   ? -47.739 17.071  -8.783  1.00 61.29  ? 449 HOH C O    1 
HETATM 3324 O  O    . HOH I 6 .   ? -49.194 16.152  -10.995 1.00 66.45  ? 450 HOH C O    1 
HETATM 3325 O  O    . HOH I 6 .   ? -45.331 -2.177  -0.761  1.00 43.96  ? 451 HOH C O    1 
HETATM 3326 O  O    . HOH I 6 .   ? -35.348 21.322  1.297   1.00 56.51  ? 452 HOH C O    1 
HETATM 3327 O  O    . HOH I 6 .   ? -42.995 1.295   -3.030  1.00 46.98  ? 453 HOH C O    1 
HETATM 3328 O  O    . HOH I 6 .   ? -19.174 3.888   -4.812  1.00 30.00  ? 454 HOH C O    1 
HETATM 3329 O  O    . HOH I 6 .   ? -38.295 -25.390 -8.512  1.00 70.52  ? 455 HOH C O    1 
HETATM 3330 O  O    . HOH I 6 .   ? -27.095 2.961   2.746   1.00 47.87  ? 456 HOH C O    1 
HETATM 3331 O  O    . HOH I 6 .   ? -41.102 -8.821  -25.097 1.00 57.54  ? 457 HOH C O    1 
HETATM 3332 O  O    . HOH I 6 .   ? -48.075 8.602   -12.840 1.00 49.97  ? 458 HOH C O    1 
HETATM 3333 O  O    . HOH I 6 .   ? -47.015 -8.019  -8.625  1.00 52.00  ? 459 HOH C O    1 
HETATM 3334 O  O    . HOH I 6 .   ? -20.961 2.500   -8.752  1.00 66.97  ? 460 HOH C O    1 
HETATM 3335 O  O    . HOH I 6 .   ? -46.370 13.681  -17.305 1.00 63.14  ? 461 HOH C O    1 
HETATM 3336 O  O    . HOH I 6 .   ? -29.547 23.145  -3.803  1.00 49.07  ? 462 HOH C O    1 
HETATM 3337 O  O    . HOH I 6 .   ? -49.584 7.130   -15.641 1.00 61.86  ? 463 HOH C O    1 
HETATM 3338 O  O    . HOH I 6 .   ? -14.469 6.631   5.401   1.00 61.74  ? 464 HOH C O    1 
# 
