data_8R0H
# 
_entry.id   8R0H 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.398 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8R0H         pdb_00008r0h 10.2210/pdb8r0h/pdb 
WWPDB D_1292134381 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2024-11-13 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8R0H 
_pdbx_database_status.recvd_initial_deposition_date   2023-10-31 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.details 
_pdbx_database_related.db_id 
_pdbx_database_related.content_type 
PDB 'complexed with another inhibitor' 7QB2 unspecified 
PDB 'complexed with another inhibitor' 7QFM unspecified 
PDB 'complexed with another inhibitor' 7Z6U unspecified 
PDB 'complexed with another inhibitor' 8AFR unspecified 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              wibke.diederich@staff.uni-marburg.de 
_pdbx_contact_author.name_first         Wibke 
_pdbx_contact_author.name_last          Diederich 
_pdbx_contact_author.name_mi            E. 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-5671-6575 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Hochban, P.M.M.' 1 0000-0003-3526-7314 
'Heine, A.'       2 0000-0002-5285-4089 
'Diederich, W.E.' 3 0000-0001-5671-6575 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Pim1 in complex with (E)-3-(2-(thiophen-2-yl)vinyl)-3,4-dihydroquinoxalin-2(1H)-one and Pimtide' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Hochban, P.M.M.' 1 0000-0003-3526-7314 
primary 'Heyder, L.'      2 ?                   
primary 'Heine, A.'       3 0000-0002-5285-4089 
primary 'Diederich, W.E.' 4 0000-0001-5671-6575 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Serine/threonine-protein kinase pim-1'             35670.477 1   2.7.11.1 R250G ? ? 
2 polymer     syn Pimtide                                             1592.850  1   ?        ?     ? ? 
3 non-polymer syn GLYCEROL                                            92.094    2   ?        ?     ? ? 
4 non-polymer syn '3-(2-thiophen-2-ylethenyl)-1~{H}-quinoxalin-2-one' 254.307   1   ?        ?     ? ? 
5 water       nat water                                               18.015    207 ?        ?     ? ? 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no yes 
;SMLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGE
LPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCH
NCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGD
IPFEHDEEIIGGQVFFRQRVS(SEP)ECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPS
;
;SMLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGE
LPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCH
NCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGD
IPFEHDEEIIGGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPS
;
A ? 
2 'polypeptide(L)' no no  ARKRRRHPSGPPTA ARKRRRHPSGPPTA B ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 GLYCEROL                                            GOL 
4 '3-(2-thiophen-2-ylethenyl)-1~{H}-quinoxalin-2-one' 8UB 
5 water                                               HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   MET n 
1 3   LEU n 
1 4   LEU n 
1 5   SER n 
1 6   LYS n 
1 7   ILE n 
1 8   ASN n 
1 9   SER n 
1 10  LEU n 
1 11  ALA n 
1 12  HIS n 
1 13  LEU n 
1 14  ARG n 
1 15  ALA n 
1 16  ALA n 
1 17  PRO n 
1 18  CYS n 
1 19  ASN n 
1 20  ASP n 
1 21  LEU n 
1 22  HIS n 
1 23  ALA n 
1 24  THR n 
1 25  LYS n 
1 26  LEU n 
1 27  ALA n 
1 28  PRO n 
1 29  GLY n 
1 30  LYS n 
1 31  GLU n 
1 32  LYS n 
1 33  GLU n 
1 34  PRO n 
1 35  LEU n 
1 36  GLU n 
1 37  SER n 
1 38  GLN n 
1 39  TYR n 
1 40  GLN n 
1 41  VAL n 
1 42  GLY n 
1 43  PRO n 
1 44  LEU n 
1 45  LEU n 
1 46  GLY n 
1 47  SER n 
1 48  GLY n 
1 49  GLY n 
1 50  PHE n 
1 51  GLY n 
1 52  SER n 
1 53  VAL n 
1 54  TYR n 
1 55  SER n 
1 56  GLY n 
1 57  ILE n 
1 58  ARG n 
1 59  VAL n 
1 60  SER n 
1 61  ASP n 
1 62  ASN n 
1 63  LEU n 
1 64  PRO n 
1 65  VAL n 
1 66  ALA n 
1 67  ILE n 
1 68  LYS n 
1 69  HIS n 
1 70  VAL n 
1 71  GLU n 
1 72  LYS n 
1 73  ASP n 
1 74  ARG n 
1 75  ILE n 
1 76  SER n 
1 77  ASP n 
1 78  TRP n 
1 79  GLY n 
1 80  GLU n 
1 81  LEU n 
1 82  PRO n 
1 83  ASN n 
1 84  GLY n 
1 85  THR n 
1 86  ARG n 
1 87  VAL n 
1 88  PRO n 
1 89  MET n 
1 90  GLU n 
1 91  VAL n 
1 92  VAL n 
1 93  LEU n 
1 94  LEU n 
1 95  LYS n 
1 96  LYS n 
1 97  VAL n 
1 98  SER n 
1 99  SER n 
1 100 GLY n 
1 101 PHE n 
1 102 SER n 
1 103 GLY n 
1 104 VAL n 
1 105 ILE n 
1 106 ARG n 
1 107 LEU n 
1 108 LEU n 
1 109 ASP n 
1 110 TRP n 
1 111 PHE n 
1 112 GLU n 
1 113 ARG n 
1 114 PRO n 
1 115 ASP n 
1 116 SER n 
1 117 PHE n 
1 118 VAL n 
1 119 LEU n 
1 120 ILE n 
1 121 LEU n 
1 122 GLU n 
1 123 ARG n 
1 124 PRO n 
1 125 GLU n 
1 126 PRO n 
1 127 VAL n 
1 128 GLN n 
1 129 ASP n 
1 130 LEU n 
1 131 PHE n 
1 132 ASP n 
1 133 PHE n 
1 134 ILE n 
1 135 THR n 
1 136 GLU n 
1 137 ARG n 
1 138 GLY n 
1 139 ALA n 
1 140 LEU n 
1 141 GLN n 
1 142 GLU n 
1 143 GLU n 
1 144 LEU n 
1 145 ALA n 
1 146 ARG n 
1 147 SER n 
1 148 PHE n 
1 149 PHE n 
1 150 TRP n 
1 151 GLN n 
1 152 VAL n 
1 153 LEU n 
1 154 GLU n 
1 155 ALA n 
1 156 VAL n 
1 157 ARG n 
1 158 HIS n 
1 159 CYS n 
1 160 HIS n 
1 161 ASN n 
1 162 CYS n 
1 163 GLY n 
1 164 VAL n 
1 165 LEU n 
1 166 HIS n 
1 167 ARG n 
1 168 ASP n 
1 169 ILE n 
1 170 LYS n 
1 171 ASP n 
1 172 GLU n 
1 173 ASN n 
1 174 ILE n 
1 175 LEU n 
1 176 ILE n 
1 177 ASP n 
1 178 LEU n 
1 179 ASN n 
1 180 ARG n 
1 181 GLY n 
1 182 GLU n 
1 183 LEU n 
1 184 LYS n 
1 185 LEU n 
1 186 ILE n 
1 187 ASP n 
1 188 PHE n 
1 189 GLY n 
1 190 SER n 
1 191 GLY n 
1 192 ALA n 
1 193 LEU n 
1 194 LEU n 
1 195 LYS n 
1 196 ASP n 
1 197 THR n 
1 198 VAL n 
1 199 TYR n 
1 200 THR n 
1 201 ASP n 
1 202 PHE n 
1 203 ASP n 
1 204 GLY n 
1 205 THR n 
1 206 ARG n 
1 207 VAL n 
1 208 TYR n 
1 209 SER n 
1 210 PRO n 
1 211 PRO n 
1 212 GLU n 
1 213 TRP n 
1 214 ILE n 
1 215 ARG n 
1 216 TYR n 
1 217 HIS n 
1 218 ARG n 
1 219 TYR n 
1 220 HIS n 
1 221 GLY n 
1 222 ARG n 
1 223 SER n 
1 224 ALA n 
1 225 ALA n 
1 226 VAL n 
1 227 TRP n 
1 228 SER n 
1 229 LEU n 
1 230 GLY n 
1 231 ILE n 
1 232 LEU n 
1 233 LEU n 
1 234 TYR n 
1 235 ASP n 
1 236 MET n 
1 237 VAL n 
1 238 CYS n 
1 239 GLY n 
1 240 ASP n 
1 241 ILE n 
1 242 PRO n 
1 243 PHE n 
1 244 GLU n 
1 245 HIS n 
1 246 ASP n 
1 247 GLU n 
1 248 GLU n 
1 249 ILE n 
1 250 ILE n 
1 251 GLY n 
1 252 GLY n 
1 253 GLN n 
1 254 VAL n 
1 255 PHE n 
1 256 PHE n 
1 257 ARG n 
1 258 GLN n 
1 259 ARG n 
1 260 VAL n 
1 261 SER n 
1 262 SEP n 
1 263 GLU n 
1 264 CYS n 
1 265 GLN n 
1 266 HIS n 
1 267 LEU n 
1 268 ILE n 
1 269 ARG n 
1 270 TRP n 
1 271 CYS n 
1 272 LEU n 
1 273 ALA n 
1 274 LEU n 
1 275 ARG n 
1 276 PRO n 
1 277 SER n 
1 278 ASP n 
1 279 ARG n 
1 280 PRO n 
1 281 THR n 
1 282 PHE n 
1 283 GLU n 
1 284 GLU n 
1 285 ILE n 
1 286 GLN n 
1 287 ASN n 
1 288 HIS n 
1 289 PRO n 
1 290 TRP n 
1 291 MET n 
1 292 GLN n 
1 293 ASP n 
1 294 VAL n 
1 295 LEU n 
1 296 LEU n 
1 297 PRO n 
1 298 GLN n 
1 299 GLU n 
1 300 THR n 
1 301 ALA n 
1 302 GLU n 
1 303 ILE n 
1 304 HIS n 
1 305 LEU n 
1 306 HIS n 
1 307 SER n 
1 308 LEU n 
1 309 SER n 
1 310 PRO n 
1 311 GLY n 
1 312 PRO n 
1 313 SER n 
2 1   ALA n 
2 2   ARG n 
2 3   LYS n 
2 4   ARG n 
2 5   ARG n 
2 6   ARG n 
2 7   HIS n 
2 8   PRO n 
2 9   SER n 
2 10  GLY n 
2 11  PRO n 
2 12  PRO n 
2 13  THR n 
2 14  ALA n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   313 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 PIM1 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       pLIC-SGC 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
_pdbx_entity_src_syn.entity_id              2 
_pdbx_entity_src_syn.pdbx_src_id            1 
_pdbx_entity_src_syn.pdbx_alt_source_flag   sample 
_pdbx_entity_src_syn.pdbx_beg_seq_num       1 
_pdbx_entity_src_syn.pdbx_end_seq_num       14 
_pdbx_entity_src_syn.organism_scientific    'Homo sapiens' 
_pdbx_entity_src_syn.organism_common_name   human 
_pdbx_entity_src_syn.ncbi_taxonomy_id       9606 
_pdbx_entity_src_syn.details                ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
8UB non-polymer         . '3-(2-thiophen-2-ylethenyl)-1~{H}-quinoxalin-2-one' ?                               'C14 H10 N2 O S' 
254.307 
ALA 'L-peptide linking' y ALANINE                                             ?                               'C3 H7 N O2'     
89.093  
ARG 'L-peptide linking' y ARGININE                                            ?                               'C6 H15 N4 O2 1' 
175.209 
ASN 'L-peptide linking' y ASPARAGINE                                          ?                               'C4 H8 N2 O3'    
132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                     ?                               'C4 H7 N O4'     
133.103 
CYS 'L-peptide linking' y CYSTEINE                                            ?                               'C3 H7 N O2 S'   
121.158 
GLN 'L-peptide linking' y GLUTAMINE                                           ?                               'C5 H10 N2 O3'   
146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                     ?                               'C5 H9 N O4'     
147.129 
GLY 'peptide linking'   y GLYCINE                                             ?                               'C2 H5 N O2'     
75.067  
GOL non-polymer         . GLYCEROL                                            'GLYCERIN; PROPANE-1,2,3-TRIOL' 'C3 H8 O3'       
92.094  
HIS 'L-peptide linking' y HISTIDINE                                           ?                               'C6 H10 N3 O2 1' 
156.162 
HOH non-polymer         . WATER                                               ?                               'H2 O'           
18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                          ?                               'C6 H13 N O2'    
131.173 
LEU 'L-peptide linking' y LEUCINE                                             ?                               'C6 H13 N O2'    
131.173 
LYS 'L-peptide linking' y LYSINE                                              ?                               'C6 H15 N2 O2 1' 
147.195 
MET 'L-peptide linking' y METHIONINE                                          ?                               'C5 H11 N O2 S'  
149.211 
PHE 'L-peptide linking' y PHENYLALANINE                                       ?                               'C9 H11 N O2'    
165.189 
PRO 'L-peptide linking' y PROLINE                                             ?                               'C5 H9 N O2'     
115.130 
SEP 'L-peptide linking' n PHOSPHOSERINE                                       PHOSPHONOSERINE                 'C3 H8 N O6 P'   
185.072 
SER 'L-peptide linking' y SERINE                                              ?                               'C3 H7 N O3'     
105.093 
THR 'L-peptide linking' y THREONINE                                           ?                               'C4 H9 N O3'     
119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                          ?                               'C11 H12 N2 O2'  
204.225 
TYR 'L-peptide linking' y TYROSINE                                            ?                               'C9 H11 N O3'    
181.189 
VAL 'L-peptide linking' y VALINE                                              ?                               'C5 H11 N O2'    
117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   0   ?   ?   ?   A . n 
A 1 2   MET 2   1   ?   ?   ?   A . n 
A 1 3   LEU 3   2   ?   ?   ?   A . n 
A 1 4   LEU 4   3   ?   ?   ?   A . n 
A 1 5   SER 5   4   ?   ?   ?   A . n 
A 1 6   LYS 6   5   ?   ?   ?   A . n 
A 1 7   ILE 7   6   ?   ?   ?   A . n 
A 1 8   ASN 8   7   ?   ?   ?   A . n 
A 1 9   SER 9   8   ?   ?   ?   A . n 
A 1 10  LEU 10  9   ?   ?   ?   A . n 
A 1 11  ALA 11  10  ?   ?   ?   A . n 
A 1 12  HIS 12  11  ?   ?   ?   A . n 
A 1 13  LEU 13  12  ?   ?   ?   A . n 
A 1 14  ARG 14  13  ?   ?   ?   A . n 
A 1 15  ALA 15  14  ?   ?   ?   A . n 
A 1 16  ALA 16  15  ?   ?   ?   A . n 
A 1 17  PRO 17  16  ?   ?   ?   A . n 
A 1 18  CYS 18  17  ?   ?   ?   A . n 
A 1 19  ASN 19  18  ?   ?   ?   A . n 
A 1 20  ASP 20  19  ?   ?   ?   A . n 
A 1 21  LEU 21  20  ?   ?   ?   A . n 
A 1 22  HIS 22  21  ?   ?   ?   A . n 
A 1 23  ALA 23  22  ?   ?   ?   A . n 
A 1 24  THR 24  23  ?   ?   ?   A . n 
A 1 25  LYS 25  24  ?   ?   ?   A . n 
A 1 26  LEU 26  25  ?   ?   ?   A . n 
A 1 27  ALA 27  26  ?   ?   ?   A . n 
A 1 28  PRO 28  27  ?   ?   ?   A . n 
A 1 29  GLY 29  28  ?   ?   ?   A . n 
A 1 30  LYS 30  29  ?   ?   ?   A . n 
A 1 31  GLU 31  30  ?   ?   ?   A . n 
A 1 32  LYS 32  31  ?   ?   ?   A . n 
A 1 33  GLU 33  32  ?   ?   ?   A . n 
A 1 34  PRO 34  33  33  PRO PRO A . n 
A 1 35  LEU 35  34  34  LEU LEU A . n 
A 1 36  GLU 36  35  35  GLU GLU A . n 
A 1 37  SER 37  36  36  SER SER A . n 
A 1 38  GLN 38  37  37  GLN GLN A . n 
A 1 39  TYR 39  38  38  TYR TYR A . n 
A 1 40  GLN 40  39  39  GLN GLN A . n 
A 1 41  VAL 41  40  40  VAL VAL A . n 
A 1 42  GLY 42  41  41  GLY GLY A . n 
A 1 43  PRO 43  42  42  PRO PRO A . n 
A 1 44  LEU 44  43  43  LEU LEU A . n 
A 1 45  LEU 45  44  44  LEU LEU A . n 
A 1 46  GLY 46  45  45  GLY GLY A . n 
A 1 47  SER 47  46  46  SER SER A . n 
A 1 48  GLY 48  47  47  GLY GLY A . n 
A 1 49  GLY 49  48  48  GLY GLY A . n 
A 1 50  PHE 50  49  49  PHE PHE A . n 
A 1 51  GLY 51  50  50  GLY GLY A . n 
A 1 52  SER 52  51  51  SER SER A . n 
A 1 53  VAL 53  52  52  VAL VAL A . n 
A 1 54  TYR 54  53  53  TYR TYR A . n 
A 1 55  SER 55  54  54  SER SER A . n 
A 1 56  GLY 56  55  55  GLY GLY A . n 
A 1 57  ILE 57  56  56  ILE ILE A . n 
A 1 58  ARG 58  57  57  ARG ARG A . n 
A 1 59  VAL 59  58  58  VAL VAL A . n 
A 1 60  SER 60  59  59  SER SER A . n 
A 1 61  ASP 61  60  60  ASP ASP A . n 
A 1 62  ASN 62  61  61  ASN ASN A . n 
A 1 63  LEU 63  62  62  LEU LEU A . n 
A 1 64  PRO 64  63  63  PRO PRO A . n 
A 1 65  VAL 65  64  64  VAL VAL A . n 
A 1 66  ALA 66  65  65  ALA ALA A . n 
A 1 67  ILE 67  66  66  ILE ILE A . n 
A 1 68  LYS 68  67  67  LYS LYS A . n 
A 1 69  HIS 69  68  68  HIS HIS A . n 
A 1 70  VAL 70  69  69  VAL VAL A . n 
A 1 71  GLU 71  70  70  GLU GLU A . n 
A 1 72  LYS 72  71  71  LYS LYS A . n 
A 1 73  ASP 73  72  72  ASP ASP A . n 
A 1 74  ARG 74  73  73  ARG ARG A . n 
A 1 75  ILE 75  74  74  ILE ILE A . n 
A 1 76  SER 76  75  75  SER SER A . n 
A 1 77  ASP 77  76  76  ASP ASP A . n 
A 1 78  TRP 78  77  77  TRP TRP A . n 
A 1 79  GLY 79  78  78  GLY GLY A . n 
A 1 80  GLU 80  79  79  GLU GLU A . n 
A 1 81  LEU 81  80  80  LEU LEU A . n 
A 1 82  PRO 82  81  81  PRO PRO A . n 
A 1 83  ASN 83  82  82  ASN ASN A . n 
A 1 84  GLY 84  83  83  GLY GLY A . n 
A 1 85  THR 85  84  84  THR THR A . n 
A 1 86  ARG 86  85  85  ARG ARG A . n 
A 1 87  VAL 87  86  86  VAL VAL A . n 
A 1 88  PRO 88  87  87  PRO PRO A . n 
A 1 89  MET 89  88  88  MET MET A . n 
A 1 90  GLU 90  89  89  GLU GLU A . n 
A 1 91  VAL 91  90  90  VAL VAL A . n 
A 1 92  VAL 92  91  91  VAL VAL A . n 
A 1 93  LEU 93  92  92  LEU LEU A . n 
A 1 94  LEU 94  93  93  LEU LEU A . n 
A 1 95  LYS 95  94  94  LYS LYS A . n 
A 1 96  LYS 96  95  95  LYS LYS A . n 
A 1 97  VAL 97  96  96  VAL VAL A . n 
A 1 98  SER 98  97  97  SER SER A . n 
A 1 99  SER 99  98  98  SER SER A . n 
A 1 100 GLY 100 99  99  GLY GLY A . n 
A 1 101 PHE 101 100 100 PHE PHE A . n 
A 1 102 SER 102 101 101 SER SER A . n 
A 1 103 GLY 103 102 102 GLY GLY A . n 
A 1 104 VAL 104 103 103 VAL VAL A . n 
A 1 105 ILE 105 104 104 ILE ILE A . n 
A 1 106 ARG 106 105 105 ARG ARG A . n 
A 1 107 LEU 107 106 106 LEU LEU A . n 
A 1 108 LEU 108 107 107 LEU LEU A . n 
A 1 109 ASP 109 108 108 ASP ASP A . n 
A 1 110 TRP 110 109 109 TRP TRP A . n 
A 1 111 PHE 111 110 110 PHE PHE A . n 
A 1 112 GLU 112 111 111 GLU GLU A . n 
A 1 113 ARG 113 112 112 ARG ARG A . n 
A 1 114 PRO 114 113 113 PRO PRO A . n 
A 1 115 ASP 115 114 114 ASP ASP A . n 
A 1 116 SER 116 115 115 SER SER A . n 
A 1 117 PHE 117 116 116 PHE PHE A . n 
A 1 118 VAL 118 117 117 VAL VAL A . n 
A 1 119 LEU 119 118 118 LEU LEU A . n 
A 1 120 ILE 120 119 119 ILE ILE A . n 
A 1 121 LEU 121 120 120 LEU LEU A . n 
A 1 122 GLU 122 121 121 GLU GLU A . n 
A 1 123 ARG 123 122 122 ARG ARG A . n 
A 1 124 PRO 124 123 123 PRO PRO A . n 
A 1 125 GLU 125 124 124 GLU GLU A . n 
A 1 126 PRO 126 125 125 PRO PRO A . n 
A 1 127 VAL 127 126 126 VAL VAL A . n 
A 1 128 GLN 128 127 127 GLN GLN A . n 
A 1 129 ASP 129 128 128 ASP ASP A . n 
A 1 130 LEU 130 129 129 LEU LEU A . n 
A 1 131 PHE 131 130 130 PHE PHE A . n 
A 1 132 ASP 132 131 131 ASP ASP A . n 
A 1 133 PHE 133 132 132 PHE PHE A . n 
A 1 134 ILE 134 133 133 ILE ILE A . n 
A 1 135 THR 135 134 134 THR THR A . n 
A 1 136 GLU 136 135 135 GLU GLU A . n 
A 1 137 ARG 137 136 136 ARG ARG A . n 
A 1 138 GLY 138 137 137 GLY GLY A . n 
A 1 139 ALA 139 138 138 ALA ALA A . n 
A 1 140 LEU 140 139 139 LEU LEU A . n 
A 1 141 GLN 141 140 140 GLN GLN A . n 
A 1 142 GLU 142 141 141 GLU GLU A . n 
A 1 143 GLU 143 142 142 GLU GLU A . n 
A 1 144 LEU 144 143 143 LEU LEU A . n 
A 1 145 ALA 145 144 144 ALA ALA A . n 
A 1 146 ARG 146 145 145 ARG ARG A . n 
A 1 147 SER 147 146 146 SER SER A . n 
A 1 148 PHE 148 147 147 PHE PHE A . n 
A 1 149 PHE 149 148 148 PHE PHE A . n 
A 1 150 TRP 150 149 149 TRP TRP A . n 
A 1 151 GLN 151 150 150 GLN GLN A . n 
A 1 152 VAL 152 151 151 VAL VAL A . n 
A 1 153 LEU 153 152 152 LEU LEU A . n 
A 1 154 GLU 154 153 153 GLU GLU A . n 
A 1 155 ALA 155 154 154 ALA ALA A . n 
A 1 156 VAL 156 155 155 VAL VAL A . n 
A 1 157 ARG 157 156 156 ARG ARG A . n 
A 1 158 HIS 158 157 157 HIS HIS A . n 
A 1 159 CYS 159 158 158 CYS CYS A . n 
A 1 160 HIS 160 159 159 HIS HIS A . n 
A 1 161 ASN 161 160 160 ASN ASN A . n 
A 1 162 CYS 162 161 161 CYS CYS A . n 
A 1 163 GLY 163 162 162 GLY GLY A . n 
A 1 164 VAL 164 163 163 VAL VAL A . n 
A 1 165 LEU 165 164 164 LEU LEU A . n 
A 1 166 HIS 166 165 165 HIS HIS A . n 
A 1 167 ARG 167 166 166 ARG ARG A . n 
A 1 168 ASP 168 167 167 ASP ASP A . n 
A 1 169 ILE 169 168 168 ILE ILE A . n 
A 1 170 LYS 170 169 169 LYS LYS A . n 
A 1 171 ASP 171 170 170 ASP ASP A . n 
A 1 172 GLU 172 171 171 GLU GLU A . n 
A 1 173 ASN 173 172 172 ASN ASN A . n 
A 1 174 ILE 174 173 173 ILE ILE A . n 
A 1 175 LEU 175 174 174 LEU LEU A . n 
A 1 176 ILE 176 175 175 ILE ILE A . n 
A 1 177 ASP 177 176 176 ASP ASP A . n 
A 1 178 LEU 178 177 177 LEU LEU A . n 
A 1 179 ASN 179 178 178 ASN ASN A . n 
A 1 180 ARG 180 179 179 ARG ARG A . n 
A 1 181 GLY 181 180 180 GLY GLY A . n 
A 1 182 GLU 182 181 181 GLU GLU A . n 
A 1 183 LEU 183 182 182 LEU LEU A . n 
A 1 184 LYS 184 183 183 LYS LYS A . n 
A 1 185 LEU 185 184 184 LEU LEU A . n 
A 1 186 ILE 186 185 185 ILE ILE A . n 
A 1 187 ASP 187 186 186 ASP ASP A . n 
A 1 188 PHE 188 187 187 PHE PHE A . n 
A 1 189 GLY 189 188 188 GLY GLY A . n 
A 1 190 SER 190 189 189 SER SER A . n 
A 1 191 GLY 191 190 190 GLY GLY A . n 
A 1 192 ALA 192 191 191 ALA ALA A . n 
A 1 193 LEU 193 192 192 LEU LEU A . n 
A 1 194 LEU 194 193 193 LEU LEU A . n 
A 1 195 LYS 195 194 194 LYS LYS A . n 
A 1 196 ASP 196 195 195 ASP ASP A . n 
A 1 197 THR 197 196 196 THR THR A . n 
A 1 198 VAL 198 197 197 VAL VAL A . n 
A 1 199 TYR 199 198 198 TYR TYR A . n 
A 1 200 THR 200 199 199 THR THR A . n 
A 1 201 ASP 201 200 200 ASP ASP A . n 
A 1 202 PHE 202 201 201 PHE PHE A . n 
A 1 203 ASP 203 202 202 ASP ASP A . n 
A 1 204 GLY 204 203 203 GLY GLY A . n 
A 1 205 THR 205 204 204 THR THR A . n 
A 1 206 ARG 206 205 205 ARG ARG A . n 
A 1 207 VAL 207 206 206 VAL VAL A . n 
A 1 208 TYR 208 207 207 TYR TYR A . n 
A 1 209 SER 209 208 208 SER SER A . n 
A 1 210 PRO 210 209 209 PRO PRO A . n 
A 1 211 PRO 211 210 210 PRO PRO A . n 
A 1 212 GLU 212 211 211 GLU GLU A . n 
A 1 213 TRP 213 212 212 TRP TRP A . n 
A 1 214 ILE 214 213 213 ILE ILE A . n 
A 1 215 ARG 215 214 214 ARG ARG A . n 
A 1 216 TYR 216 215 215 TYR TYR A . n 
A 1 217 HIS 217 216 216 HIS HIS A . n 
A 1 218 ARG 218 217 217 ARG ARG A . n 
A 1 219 TYR 219 218 218 TYR TYR A . n 
A 1 220 HIS 220 219 219 HIS HIS A . n 
A 1 221 GLY 221 220 220 GLY GLY A . n 
A 1 222 ARG 222 221 221 ARG ARG A . n 
A 1 223 SER 223 222 222 SER SER A . n 
A 1 224 ALA 224 223 223 ALA ALA A . n 
A 1 225 ALA 225 224 224 ALA ALA A . n 
A 1 226 VAL 226 225 225 VAL VAL A . n 
A 1 227 TRP 227 226 226 TRP TRP A . n 
A 1 228 SER 228 227 227 SER SER A . n 
A 1 229 LEU 229 228 228 LEU LEU A . n 
A 1 230 GLY 230 229 229 GLY GLY A . n 
A 1 231 ILE 231 230 230 ILE ILE A . n 
A 1 232 LEU 232 231 231 LEU LEU A . n 
A 1 233 LEU 233 232 232 LEU LEU A . n 
A 1 234 TYR 234 233 233 TYR TYR A . n 
A 1 235 ASP 235 234 234 ASP ASP A . n 
A 1 236 MET 236 235 235 MET MET A . n 
A 1 237 VAL 237 236 236 VAL VAL A . n 
A 1 238 CYS 238 237 237 CYS CYS A . n 
A 1 239 GLY 239 238 238 GLY GLY A . n 
A 1 240 ASP 240 239 239 ASP ASP A . n 
A 1 241 ILE 241 240 240 ILE ILE A . n 
A 1 242 PRO 242 241 241 PRO PRO A . n 
A 1 243 PHE 243 242 242 PHE PHE A . n 
A 1 244 GLU 244 243 243 GLU GLU A . n 
A 1 245 HIS 245 244 244 HIS HIS A . n 
A 1 246 ASP 246 245 245 ASP ASP A . n 
A 1 247 GLU 247 246 246 GLU GLU A . n 
A 1 248 GLU 248 247 247 GLU GLU A . n 
A 1 249 ILE 249 248 248 ILE ILE A . n 
A 1 250 ILE 250 249 249 ILE ILE A . n 
A 1 251 GLY 251 250 250 GLY GLY A . n 
A 1 252 GLY 252 251 251 GLY GLY A . n 
A 1 253 GLN 253 252 252 GLN GLN A . n 
A 1 254 VAL 254 253 253 VAL VAL A . n 
A 1 255 PHE 255 254 254 PHE PHE A . n 
A 1 256 PHE 256 255 255 PHE PHE A . n 
A 1 257 ARG 257 256 256 ARG ARG A . n 
A 1 258 GLN 258 257 257 GLN GLN A . n 
A 1 259 ARG 259 258 258 ARG ARG A . n 
A 1 260 VAL 260 259 259 VAL VAL A . n 
A 1 261 SER 261 260 260 SER SER A . n 
A 1 262 SEP 262 261 261 SEP SEP A . n 
A 1 263 GLU 263 262 262 GLU GLU A . n 
A 1 264 CYS 264 263 263 CYS CYS A . n 
A 1 265 GLN 265 264 264 GLN GLN A . n 
A 1 266 HIS 266 265 265 HIS HIS A . n 
A 1 267 LEU 267 266 266 LEU LEU A . n 
A 1 268 ILE 268 267 267 ILE ILE A . n 
A 1 269 ARG 269 268 268 ARG ARG A . n 
A 1 270 TRP 270 269 269 TRP TRP A . n 
A 1 271 CYS 271 270 270 CYS CYS A . n 
A 1 272 LEU 272 271 271 LEU LEU A . n 
A 1 273 ALA 273 272 272 ALA ALA A . n 
A 1 274 LEU 274 273 273 LEU LEU A . n 
A 1 275 ARG 275 274 274 ARG ARG A . n 
A 1 276 PRO 276 275 275 PRO PRO A . n 
A 1 277 SER 277 276 276 SER SER A . n 
A 1 278 ASP 278 277 277 ASP ASP A . n 
A 1 279 ARG 279 278 278 ARG ARG A . n 
A 1 280 PRO 280 279 279 PRO PRO A . n 
A 1 281 THR 281 280 280 THR THR A . n 
A 1 282 PHE 282 281 281 PHE PHE A . n 
A 1 283 GLU 283 282 282 GLU GLU A . n 
A 1 284 GLU 284 283 283 GLU GLU A . n 
A 1 285 ILE 285 284 284 ILE ILE A . n 
A 1 286 GLN 286 285 285 GLN GLN A . n 
A 1 287 ASN 287 286 286 ASN ASN A . n 
A 1 288 HIS 288 287 287 HIS HIS A . n 
A 1 289 PRO 289 288 288 PRO PRO A . n 
A 1 290 TRP 290 289 289 TRP TRP A . n 
A 1 291 MET 291 290 290 MET MET A . n 
A 1 292 GLN 292 291 291 GLN GLN A . n 
A 1 293 ASP 293 292 292 ASP ASP A . n 
A 1 294 VAL 294 293 293 VAL VAL A . n 
A 1 295 LEU 295 294 294 LEU LEU A . n 
A 1 296 LEU 296 295 295 LEU LEU A . n 
A 1 297 PRO 297 296 296 PRO PRO A . n 
A 1 298 GLN 298 297 297 GLN GLN A . n 
A 1 299 GLU 299 298 298 GLU GLU A . n 
A 1 300 THR 300 299 299 THR THR A . n 
A 1 301 ALA 301 300 300 ALA ALA A . n 
A 1 302 GLU 302 301 301 GLU GLU A . n 
A 1 303 ILE 303 302 302 ILE ILE A . n 
A 1 304 HIS 304 303 303 HIS HIS A . n 
A 1 305 LEU 305 304 304 LEU LEU A . n 
A 1 306 HIS 306 305 305 HIS HIS A . n 
A 1 307 SER 307 306 ?   ?   ?   A . n 
A 1 308 LEU 308 307 ?   ?   ?   A . n 
A 1 309 SER 309 308 ?   ?   ?   A . n 
A 1 310 PRO 310 309 ?   ?   ?   A . n 
A 1 311 GLY 311 310 ?   ?   ?   A . n 
A 1 312 PRO 312 311 ?   ?   ?   A . n 
A 1 313 SER 313 312 ?   ?   ?   A . n 
B 2 1   ALA 1   1   ?   ?   ?   B . n 
B 2 2   ARG 2   2   2   ARG ARG B . n 
B 2 3   LYS 3   3   3   LYS LYS B . n 
B 2 4   ARG 4   4   4   ARG ARG B . n 
B 2 5   ARG 5   5   5   ARG ARG B . n 
B 2 6   ARG 6   6   6   ARG ARG B . n 
B 2 7   HIS 7   7   7   HIS HIS B . n 
B 2 8   PRO 8   8   8   PRO PRO B . n 
B 2 9   SER 9   9   9   SER SER B . n 
B 2 10  GLY 10  10  10  GLY GLY B . n 
B 2 11  PRO 11  11  ?   ?   ?   B . n 
B 2 12  PRO 12  12  ?   ?   ?   B . n 
B 2 13  THR 13  13  ?   ?   ?   B . n 
B 2 14  ALA 14  14  ?   ?   ?   B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        8UB 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   8UB 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 3 GOL 1   401 1   GOL GOL A . 
D 3 GOL 1   402 2   GOL GOL A . 
E 4 8UB 1   403 1   8UB LHD A . 
F 5 HOH 1   501 189 HOH HOH A . 
F 5 HOH 2   502 142 HOH HOH A . 
F 5 HOH 3   503 256 HOH HOH A . 
F 5 HOH 4   504 225 HOH HOH A . 
F 5 HOH 5   505 134 HOH HOH A . 
F 5 HOH 6   506 119 HOH HOH A . 
F 5 HOH 7   507 252 HOH HOH A . 
F 5 HOH 8   508 196 HOH HOH A . 
F 5 HOH 9   509 120 HOH HOH A . 
F 5 HOH 10  510 226 HOH HOH A . 
F 5 HOH 11  511 101 HOH HOH A . 
F 5 HOH 12  512 12  HOH HOH A . 
F 5 HOH 13  513 66  HOH HOH A . 
F 5 HOH 14  514 71  HOH HOH A . 
F 5 HOH 15  515 108 HOH HOH A . 
F 5 HOH 16  516 82  HOH HOH A . 
F 5 HOH 17  517 173 HOH HOH A . 
F 5 HOH 18  518 122 HOH HOH A . 
F 5 HOH 19  519 94  HOH HOH A . 
F 5 HOH 20  520 65  HOH HOH A . 
F 5 HOH 21  521 24  HOH HOH A . 
F 5 HOH 22  522 114 HOH HOH A . 
F 5 HOH 23  523 131 HOH HOH A . 
F 5 HOH 24  524 90  HOH HOH A . 
F 5 HOH 25  525 113 HOH HOH A . 
F 5 HOH 26  526 146 HOH HOH A . 
F 5 HOH 27  527 54  HOH HOH A . 
F 5 HOH 28  528 48  HOH HOH A . 
F 5 HOH 29  529 6   HOH HOH A . 
F 5 HOH 30  530 129 HOH HOH A . 
F 5 HOH 31  531 74  HOH HOH A . 
F 5 HOH 32  532 30  HOH HOH A . 
F 5 HOH 33  533 73  HOH HOH A . 
F 5 HOH 34  534 169 HOH HOH A . 
F 5 HOH 35  535 143 HOH HOH A . 
F 5 HOH 36  536 43  HOH HOH A . 
F 5 HOH 37  537 105 HOH HOH A . 
F 5 HOH 38  538 2   HOH HOH A . 
F 5 HOH 39  539 92  HOH HOH A . 
F 5 HOH 40  540 58  HOH HOH A . 
F 5 HOH 41  541 161 HOH HOH A . 
F 5 HOH 42  542 25  HOH HOH A . 
F 5 HOH 43  543 45  HOH HOH A . 
F 5 HOH 44  544 99  HOH HOH A . 
F 5 HOH 45  545 204 HOH HOH A . 
F 5 HOH 46  546 32  HOH HOH A . 
F 5 HOH 47  547 33  HOH HOH A . 
F 5 HOH 48  548 76  HOH HOH A . 
F 5 HOH 49  549 36  HOH HOH A . 
F 5 HOH 50  550 79  HOH HOH A . 
F 5 HOH 51  551 84  HOH HOH A . 
F 5 HOH 52  552 89  HOH HOH A . 
F 5 HOH 53  553 27  HOH HOH A . 
F 5 HOH 54  554 40  HOH HOH A . 
F 5 HOH 55  555 93  HOH HOH A . 
F 5 HOH 56  556 150 HOH HOH A . 
F 5 HOH 57  557 154 HOH HOH A . 
F 5 HOH 58  558 109 HOH HOH A . 
F 5 HOH 59  559 183 HOH HOH A . 
F 5 HOH 60  560 3   HOH HOH A . 
F 5 HOH 61  561 22  HOH HOH A . 
F 5 HOH 62  562 218 HOH HOH A . 
F 5 HOH 63  563 191 HOH HOH A . 
F 5 HOH 64  564 8   HOH HOH A . 
F 5 HOH 65  565 13  HOH HOH A . 
F 5 HOH 66  566 44  HOH HOH A . 
F 5 HOH 67  567 227 HOH HOH A . 
F 5 HOH 68  568 164 HOH HOH A . 
F 5 HOH 69  569 5   HOH HOH A . 
F 5 HOH 70  570 26  HOH HOH A . 
F 5 HOH 71  571 31  HOH HOH A . 
F 5 HOH 72  572 236 HOH HOH A . 
F 5 HOH 73  573 15  HOH HOH A . 
F 5 HOH 74  574 104 HOH HOH A . 
F 5 HOH 75  575 38  HOH HOH A . 
F 5 HOH 76  576 51  HOH HOH A . 
F 5 HOH 77  577 11  HOH HOH A . 
F 5 HOH 78  578 222 HOH HOH A . 
F 5 HOH 79  579 229 HOH HOH A . 
F 5 HOH 80  580 49  HOH HOH A . 
F 5 HOH 81  581 141 HOH HOH A . 
F 5 HOH 82  582 151 HOH HOH A . 
F 5 HOH 83  583 137 HOH HOH A . 
F 5 HOH 84  584 221 HOH HOH A . 
F 5 HOH 85  585 1   HOH HOH A . 
F 5 HOH 86  586 107 HOH HOH A . 
F 5 HOH 87  587 118 HOH HOH A . 
F 5 HOH 88  588 124 HOH HOH A . 
F 5 HOH 89  589 133 HOH HOH A . 
F 5 HOH 90  590 159 HOH HOH A . 
F 5 HOH 91  591 156 HOH HOH A . 
F 5 HOH 92  592 4   HOH HOH A . 
F 5 HOH 93  593 14  HOH HOH A . 
F 5 HOH 94  594 123 HOH HOH A . 
F 5 HOH 95  595 181 HOH HOH A . 
F 5 HOH 96  596 69  HOH HOH A . 
F 5 HOH 97  597 21  HOH HOH A . 
F 5 HOH 98  598 166 HOH HOH A . 
F 5 HOH 99  599 194 HOH HOH A . 
F 5 HOH 100 600 188 HOH HOH A . 
F 5 HOH 101 601 19  HOH HOH A . 
F 5 HOH 102 602 110 HOH HOH A . 
F 5 HOH 103 603 135 HOH HOH A . 
F 5 HOH 104 604 140 HOH HOH A . 
F 5 HOH 105 605 80  HOH HOH A . 
F 5 HOH 106 606 228 HOH HOH A . 
F 5 HOH 107 607 215 HOH HOH A . 
F 5 HOH 108 608 63  HOH HOH A . 
F 5 HOH 109 609 145 HOH HOH A . 
F 5 HOH 110 610 100 HOH HOH A . 
F 5 HOH 111 611 206 HOH HOH A . 
F 5 HOH 112 612 17  HOH HOH A . 
F 5 HOH 113 613 78  HOH HOH A . 
F 5 HOH 114 614 112 HOH HOH A . 
F 5 HOH 115 615 7   HOH HOH A . 
F 5 HOH 116 616 64  HOH HOH A . 
F 5 HOH 117 617 28  HOH HOH A . 
F 5 HOH 118 618 83  HOH HOH A . 
F 5 HOH 119 619 230 HOH HOH A . 
F 5 HOH 120 620 178 HOH HOH A . 
F 5 HOH 121 621 251 HOH HOH A . 
F 5 HOH 122 622 55  HOH HOH A . 
F 5 HOH 123 623 111 HOH HOH A . 
F 5 HOH 124 624 57  HOH HOH A . 
F 5 HOH 125 625 160 HOH HOH A . 
F 5 HOH 126 626 72  HOH HOH A . 
F 5 HOH 127 627 174 HOH HOH A . 
F 5 HOH 128 628 153 HOH HOH A . 
F 5 HOH 129 629 177 HOH HOH A . 
F 5 HOH 130 630 85  HOH HOH A . 
F 5 HOH 131 631 86  HOH HOH A . 
F 5 HOH 132 632 53  HOH HOH A . 
F 5 HOH 133 633 149 HOH HOH A . 
F 5 HOH 134 634 20  HOH HOH A . 
F 5 HOH 135 635 91  HOH HOH A . 
F 5 HOH 136 636 197 HOH HOH A . 
F 5 HOH 137 637 136 HOH HOH A . 
F 5 HOH 138 638 52  HOH HOH A . 
F 5 HOH 139 639 75  HOH HOH A . 
F 5 HOH 140 640 62  HOH HOH A . 
F 5 HOH 141 641 216 HOH HOH A . 
F 5 HOH 142 642 203 HOH HOH A . 
F 5 HOH 143 643 172 HOH HOH A . 
F 5 HOH 144 644 147 HOH HOH A . 
F 5 HOH 145 645 68  HOH HOH A . 
F 5 HOH 146 646 9   HOH HOH A . 
F 5 HOH 147 647 219 HOH HOH A . 
F 5 HOH 148 648 126 HOH HOH A . 
F 5 HOH 149 649 39  HOH HOH A . 
F 5 HOH 150 650 37  HOH HOH A . 
F 5 HOH 151 651 106 HOH HOH A . 
F 5 HOH 152 652 98  HOH HOH A . 
F 5 HOH 153 653 117 HOH HOH A . 
F 5 HOH 154 654 67  HOH HOH A . 
F 5 HOH 155 655 10  HOH HOH A . 
F 5 HOH 156 656 60  HOH HOH A . 
F 5 HOH 157 657 18  HOH HOH A . 
F 5 HOH 158 658 220 HOH HOH A . 
F 5 HOH 159 659 116 HOH HOH A . 
F 5 HOH 160 660 81  HOH HOH A . 
F 5 HOH 161 661 87  HOH HOH A . 
F 5 HOH 162 662 35  HOH HOH A . 
F 5 HOH 163 663 253 HOH HOH A . 
F 5 HOH 164 664 163 HOH HOH A . 
F 5 HOH 165 665 254 HOH HOH A . 
F 5 HOH 166 666 42  HOH HOH A . 
F 5 HOH 167 667 210 HOH HOH A . 
F 5 HOH 168 668 102 HOH HOH A . 
F 5 HOH 169 669 214 HOH HOH A . 
F 5 HOH 170 670 207 HOH HOH A . 
F 5 HOH 171 671 187 HOH HOH A . 
F 5 HOH 172 672 231 HOH HOH A . 
F 5 HOH 173 673 250 HOH HOH A . 
F 5 HOH 174 674 70  HOH HOH A . 
F 5 HOH 175 675 247 HOH HOH A . 
F 5 HOH 176 676 59  HOH HOH A . 
F 5 HOH 177 677 239 HOH HOH A . 
F 5 HOH 178 678 61  HOH HOH A . 
F 5 HOH 179 679 185 HOH HOH A . 
F 5 HOH 180 680 213 HOH HOH A . 
F 5 HOH 181 681 223 HOH HOH A . 
F 5 HOH 182 682 121 HOH HOH A . 
F 5 HOH 183 683 246 HOH HOH A . 
F 5 HOH 184 684 237 HOH HOH A . 
F 5 HOH 185 685 235 HOH HOH A . 
F 5 HOH 186 686 255 HOH HOH A . 
F 5 HOH 187 687 179 HOH HOH A . 
F 5 HOH 188 688 115 HOH HOH A . 
F 5 HOH 189 689 88  HOH HOH A . 
F 5 HOH 190 690 217 HOH HOH A . 
F 5 HOH 191 691 77  HOH HOH A . 
F 5 HOH 192 692 212 HOH HOH A . 
F 5 HOH 193 693 23  HOH HOH A . 
F 5 HOH 194 694 168 HOH HOH A . 
F 5 HOH 195 695 180 HOH HOH A . 
F 5 HOH 196 696 243 HOH HOH A . 
F 5 HOH 197 697 184 HOH HOH A . 
F 5 HOH 198 698 170 HOH HOH A . 
F 5 HOH 199 699 46  HOH HOH A . 
F 5 HOH 200 700 205 HOH HOH A . 
F 5 HOH 201 701 245 HOH HOH A . 
G 5 HOH 1   101 56  HOH HOH B . 
G 5 HOH 2   102 195 HOH HOH B . 
G 5 HOH 3   103 41  HOH HOH B . 
G 5 HOH 4   104 175 HOH HOH B . 
G 5 HOH 5   105 242 HOH HOH B . 
G 5 HOH 6   106 29  HOH HOH B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A GLU 35  ? OE1 ? A GLU 36  OE1 
2  1 Y 1 A GLU 35  ? OE2 ? A GLU 36  OE2 
3  1 Y 1 A GLN 39  ? CD  ? A GLN 40  CD  
4  1 Y 1 A GLN 39  ? OE1 ? A GLN 40  OE1 
5  1 Y 1 A GLN 39  ? NE2 ? A GLN 40  NE2 
6  1 Y 1 A ILE 56  ? CD1 ? A ILE 57  CD1 
7  1 Y 1 A SER 59  ? OG  ? A SER 60  OG  
8  1 Y 1 A ASN 61  ? OD1 ? A ASN 62  OD1 
9  1 Y 1 A ASN 61  ? ND2 ? A ASN 62  ND2 
10 1 Y 1 A GLU 70  ? CD  ? A GLU 71  CD  
11 1 Y 1 A GLU 70  ? OE1 ? A GLU 71  OE1 
12 1 Y 1 A GLU 70  ? OE2 ? A GLU 71  OE2 
13 1 Y 1 A ARG 73  ? CD  ? A ARG 74  CD  
14 1 Y 1 A ARG 73  ? NE  ? A ARG 74  NE  
15 1 Y 1 A ARG 73  ? CZ  ? A ARG 74  CZ  
16 1 Y 1 A ARG 73  ? NH1 ? A ARG 74  NH1 
17 1 Y 1 A ARG 73  ? NH2 ? A ARG 74  NH2 
18 1 Y 1 A SER 75  ? OG  ? A SER 76  OG  
19 1 Y 1 A ASP 76  ? OD1 ? A ASP 77  OD1 
20 1 Y 1 A ASP 76  ? OD2 ? A ASP 77  OD2 
21 1 Y 1 A GLU 79  ? CG  ? A GLU 80  CG  
22 1 Y 1 A GLU 79  ? CD  ? A GLU 80  CD  
23 1 Y 1 A GLU 79  ? OE1 ? A GLU 80  OE1 
24 1 Y 1 A GLU 79  ? OE2 ? A GLU 80  OE2 
25 1 Y 1 A LEU 80  ? CG  ? A LEU 81  CG  
26 1 Y 1 A LEU 80  ? CD1 ? A LEU 81  CD1 
27 1 Y 1 A LEU 80  ? CD2 ? A LEU 81  CD2 
28 1 Y 1 A ASN 82  ? CG  ? A ASN 83  CG  
29 1 Y 1 A ASN 82  ? OD1 ? A ASN 83  OD1 
30 1 Y 1 A ASN 82  ? ND2 ? A ASN 83  ND2 
31 1 Y 1 A THR 84  ? OG1 ? A THR 85  OG1 
32 1 Y 1 A THR 84  ? CG2 ? A THR 85  CG2 
33 1 Y 1 A LYS 94  ? CE  ? A LYS 95  CE  
34 1 Y 1 A LYS 94  ? NZ  ? A LYS 95  NZ  
35 1 Y 1 A SER 98  ? OG  ? A SER 99  OG  
36 1 Y 1 A GLU 246 ? OE2 ? A GLU 247 OE2 
37 1 Y 1 A GLN 252 ? OE1 ? A GLN 253 OE1 
38 1 Y 1 A GLN 252 ? NE2 ? A GLN 253 NE2 
39 1 Y 1 A GLU 262 ? OE1 ? A GLU 263 OE1 
40 1 Y 1 A GLN 297 ? CG  ? A GLN 298 CG  
41 1 Y 1 A GLN 297 ? CD  ? A GLN 298 CD  
42 1 Y 1 A GLN 297 ? OE1 ? A GLN 298 OE1 
43 1 Y 1 A GLN 297 ? NE2 ? A GLN 298 NE2 
44 1 Y 1 B LYS 3   ? CG  ? B LYS 3   CG  
45 1 Y 1 B LYS 3   ? CD  ? B LYS 3   CD  
46 1 Y 1 B LYS 3   ? CE  ? B LYS 3   CE  
47 1 Y 1 B LYS 3   ? NZ  ? B LYS 3   NZ  
48 1 Y 1 B ARG 5   ? NH2 ? B ARG 5   NH2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement        ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.20.1_4487 1 
? 'data collection' ? ? ? ? ? ? ? ? ? ? ? MxCuBE ? ? ? .           2 
? 'data reduction'  ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? 1.02        3 
? 'data scaling'    ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? 1.02        4 
? phasing           ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .           5 
? 'model building'  ? ? ? ? ? ? ? ? ? ? ? Coot   ? ? ? 0.7.1       6 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8R0H 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     98.304 
_cell.length_a_esd                 ? 
_cell.length_b                     98.304 
_cell.length_b_esd                 ? 
_cell.length_c                     80.339 
_cell.length_c_esd                 ? 
_cell.volume                       672356.229 
_cell.volume_esd                   ? 
_cell.Z_PDB                        6 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8R0H 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                170 
_symmetry.space_group_name_Hall            'P 65' 
_symmetry.space_group_name_H-M             'P 65' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8R0H 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             3.06 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          59.83 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.0 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
'100 mM bis-tris-propane (pH 7.0), 10% ethylene glycol, 0.3% DMSO, 20% PEG3350, 200 mM Mg(OAc)2' 
_exptl_crystal_grow.pdbx_pH_range   6.8-7.2 
_exptl_crystal_grow.temp            291.15 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      'Sagitally bended Si111-crystal' 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2020-02-01 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    'Double crystal' 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.9184 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'BESSY BEAMLINE 14.1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.9184 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   14.1 
_diffrn_source.pdbx_synchrotron_site       BESSY 
# 
_reflns.B_iso_Wilson_estimate                          27.11 
_reflns.entry_id                                       8R0H 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.88 
_reflns.d_resolution_low                               49.15 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     35994 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.9 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                8.0 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          17.7 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.99 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                7.0 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.88 
_reflns_shell.d_res_low                                     1.89 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             5758 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.92 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               52.1 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               32.72 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8R0H 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.88 
_refine.ls_d_res_low                             49.15 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     35989 
_refine.ls_number_reflns_R_free                  1800 
_refine.ls_number_reflns_R_work                  34189 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.85 
_refine.ls_percent_reflns_R_free                 5.00 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1554 
_refine.ls_R_factor_R_free                       0.1741 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1544 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.37 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 16.8345 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1620 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.88 
_refine_hist.d_res_low                        49.15 
_refine_hist.number_atoms_solvent             207 
_refine_hist.number_atoms_total               2490 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2253 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         30 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0071  ? 2405 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.8030  ? 3269 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0524  ? 347  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0083  ? 444  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 11.6132 ? 896  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.88 1.93  . . 138 2618 98.82  . . . . 0.2018 . . . . . . . . . . . 0.2333 
'X-RAY DIFFRACTION' 1.93 1.99  . . 138 2622 100.00 . . . . 0.1691 . . . . . . . . . . . 0.1987 
'X-RAY DIFFRACTION' 1.99 2.05  . . 137 2618 99.96  . . . . 0.1539 . . . . . . . . . . . 0.2101 
'X-RAY DIFFRACTION' 2.05 2.12  . . 137 2593 100.00 . . . . 0.1571 . . . . . . . . . . . 0.1851 
'X-RAY DIFFRACTION' 2.12 2.21  . . 138 2614 99.96  . . . . 0.1509 . . . . . . . . . . . 0.1854 
'X-RAY DIFFRACTION' 2.21 2.31  . . 139 2647 100.00 . . . . 0.1462 . . . . . . . . . . . 0.1732 
'X-RAY DIFFRACTION' 2.31 2.43  . . 138 2623 99.96  . . . . 0.1458 . . . . . . . . . . . 0.1707 
'X-RAY DIFFRACTION' 2.43 2.58  . . 138 2629 99.93  . . . . 0.1646 . . . . . . . . . . . 0.1917 
'X-RAY DIFFRACTION' 2.58 2.78  . . 138 2621 99.96  . . . . 0.1711 . . . . . . . . . . . 0.1973 
'X-RAY DIFFRACTION' 2.78 3.06  . . 139 2637 99.96  . . . . 0.1566 . . . . . . . . . . . 0.1769 
'X-RAY DIFFRACTION' 3.06 3.51  . . 138 2627 99.89  . . . . 0.1545 . . . . . . . . . . . 0.1695 
'X-RAY DIFFRACTION' 3.51 4.41  . . 140 2650 100.00 . . . . 0.1344 . . . . . . . . . . . 0.1489 
'X-RAY DIFFRACTION' 4.42 49.15 . . 142 2690 99.68  . . . . 0.1608 . . . . . . . . . . . 0.1657 
# 
_struct.entry_id                     8R0H 
_struct.title                        
'Pim1 in complex with (E)-3-(2-(thiophen-2-yl)vinyl)-3,4-dihydroquinoxalin-2(1H)-one and Pimtide' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8R0H 
_struct_keywords.text            
;SERINE KINASE, KINASE, COMPLEX, PIM1, PIM, PIM-1, INHIBITOR, TUMORIGENISIS, CANCER, PIMTIDE, PROTO ONCOGEN, ATP, PHOSPHORYLATION, APOPTOSIS, CELL CYCLE, TRANSFERASE
;
_struct_keywords.pdbx_keywords   TRANSFERASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 3 ? 
E N N 4 ? 
F N N 5 ? 
G N N 5 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP PIM1_HUMAN P11309 P11309-1 1 
;MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGEL
PNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHN
CGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPS
;
1 
2 PDB 8R0H       8R0H   ?        2 ? 1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 8R0H A 2 ? 313 ? P11309 1 ? 312 ? 1 312 
2 2 8R0H B 1 ? 14  ? 8R0H   1 ? 14  ? 1 14  
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8R0H SER A 1   ? UNP P11309 ?   ?   'expression tag'      0   1 
1 8R0H GLY A 251 ? UNP P11309 ARG 250 'engineered mutation' 250 2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 1770  ? 
1 MORE         3     ? 
1 'SSA (A^2)'  12870 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 PRO A 34  ? GLN A 38  ? PRO A 33  GLN A 37  1 ? 5  
HELX_P HELX_P2  AA2 ASP A 73  ? ILE A 75  ? ASP A 72  ILE A 74  5 ? 3  
HELX_P HELX_P3  AA3 MET A 89  ? SER A 98  ? MET A 88  SER A 97  1 ? 10 
HELX_P HELX_P4  AA4 LEU A 130 ? GLY A 138 ? LEU A 129 GLY A 137 1 ? 9  
HELX_P HELX_P5  AA5 GLN A 141 ? CYS A 162 ? GLN A 140 CYS A 161 1 ? 22 
HELX_P HELX_P6  AA6 LYS A 170 ? GLU A 172 ? LYS A 169 GLU A 171 5 ? 3  
HELX_P HELX_P7  AA7 THR A 205 ? SER A 209 ? THR A 204 SER A 208 5 ? 5  
HELX_P HELX_P8  AA8 PRO A 210 ? HIS A 217 ? PRO A 209 HIS A 216 1 ? 8  
HELX_P HELX_P9  AA9 HIS A 220 ? GLY A 239 ? HIS A 219 GLY A 238 1 ? 20 
HELX_P HELX_P10 AB1 HIS A 245 ? GLY A 252 ? HIS A 244 GLY A 251 1 ? 8  
HELX_P HELX_P11 AB2 SER A 261 ? LEU A 272 ? SER A 260 LEU A 271 1 ? 12 
HELX_P HELX_P12 AB3 ARG A 275 ? ARG A 279 ? ARG A 274 ARG A 278 5 ? 5  
HELX_P HELX_P13 AB4 THR A 281 ? ASN A 287 ? THR A 280 ASN A 286 1 ? 7  
HELX_P HELX_P14 AB5 HIS A 288 ? GLN A 292 ? HIS A 287 GLN A 291 5 ? 5  
HELX_P HELX_P15 AB6 LEU A 296 ? LEU A 305 ? LEU A 295 LEU A 304 1 ? 10 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
covale1 covale both ? A SER 261 C ? ? ? 1_555 A SEP 262 N ? ? A SER 260 A SEP 261 1_555 ? ? ? ? ? ? ? 1.326 ? ? 
covale2 covale both ? A SEP 262 C ? ? ? 1_555 A GLU 263 N ? ? A SEP 261 A GLU 262 1_555 ? ? ? ? ? ? ? 1.330 ? ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      SEP 
_pdbx_modification_feature.label_asym_id                      A 
_pdbx_modification_feature.label_seq_id                       262 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     . 
_pdbx_modification_feature.modified_residue_label_asym_id     . 
_pdbx_modification_feature.modified_residue_label_seq_id      . 
_pdbx_modification_feature.modified_residue_label_alt_id      . 
_pdbx_modification_feature.auth_comp_id                       SEP 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        261 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      . 
_pdbx_modification_feature.modified_residue_auth_asym_id      . 
_pdbx_modification_feature.modified_residue_auth_seq_id       . 
_pdbx_modification_feature.modified_residue_PDB_ins_code      . 
_pdbx_modification_feature.modified_residue_symmetry          . 
_pdbx_modification_feature.comp_id_linking_atom               . 
_pdbx_modification_feature.modified_residue_id_linking_atom   . 
_pdbx_modification_feature.modified_residue_id                SER 
_pdbx_modification_feature.ref_pcm_id                         1 
_pdbx_modification_feature.ref_comp_id                        SEP 
_pdbx_modification_feature.type                               Phosphorylation 
_pdbx_modification_feature.category                           'Named protein modification' 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          GLU 
_struct_mon_prot_cis.label_seq_id           125 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           GLU 
_struct_mon_prot_cis.auth_seq_id            124 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    126 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     125 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       -3.33 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 2 ? 
AA3 ? 3 ? 
AA4 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA4 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 TYR A 39  ? GLY A 48  ? TYR A 38  GLY A 47  
AA1 2 GLY A 51  ? ARG A 58  ? GLY A 50  ARG A 57  
AA1 3 LEU A 63  ? GLU A 71  ? LEU A 62  GLU A 70  
AA1 4 SER A 116 ? GLU A 122 ? SER A 115 GLU A 121 
AA1 5 LEU A 107 ? GLU A 112 ? LEU A 106 GLU A 111 
AA2 1 TRP A 78  ? GLU A 80  ? TRP A 77  GLU A 79  
AA2 2 ARG A 86  ? PRO A 88  ? ARG A 85  PRO A 87  
AA3 1 VAL A 127 ? ASP A 129 ? VAL A 126 ASP A 128 
AA3 2 ILE A 174 ? ASP A 177 ? ILE A 173 ASP A 176 
AA3 3 GLU A 182 ? LEU A 185 ? GLU A 181 LEU A 184 
AA4 1 VAL A 164 ? LEU A 165 ? VAL A 163 LEU A 164 
AA4 2 ALA A 192 ? LEU A 193 ? ALA A 191 LEU A 192 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N GLY A 42  ? N GLY A 41  O SER A 55  ? O SER A 54  
AA1 2 3 N TYR A 54  ? N TYR A 53  O ILE A 67  ? O ILE A 66  
AA1 3 4 N LYS A 68  ? N LYS A 67  O LEU A 119 ? O LEU A 118 
AA1 4 5 O ILE A 120 ? O ILE A 119 N LEU A 108 ? N LEU A 107 
AA2 1 2 N GLY A 79  ? N GLY A 78  O VAL A 87  ? O VAL A 86  
AA3 1 2 N GLN A 128 ? N GLN A 127 O ILE A 176 ? O ILE A 175 
AA3 2 3 N ASP A 177 ? N ASP A 176 O GLU A 182 ? O GLU A 181 
AA4 1 2 N LEU A 165 ? N LEU A 164 O ALA A 192 ? O ALA A 191 
# 
_pdbx_entry_details.entry_id                   8R0H 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 167 ? ? -150.46 41.97 
2 1 ASP A 186 ? ? 64.03   75.42 
# 
_pdbx_struct_mod_residue.id               1 
_pdbx_struct_mod_residue.label_asym_id    A 
_pdbx_struct_mod_residue.label_comp_id    SEP 
_pdbx_struct_mod_residue.label_seq_id     262 
_pdbx_struct_mod_residue.auth_asym_id     A 
_pdbx_struct_mod_residue.auth_comp_id     SEP 
_pdbx_struct_mod_residue.auth_seq_id      261 
_pdbx_struct_mod_residue.PDB_ins_code     ? 
_pdbx_struct_mod_residue.parent_comp_id   SER 
_pdbx_struct_mod_residue.details          'modified residue' 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z         
2 x-y,x,z+5/6   
3 y,-x+y,z+1/6  
4 -y,x-y,z+2/3  
5 -x+y,-x,z+1/3 
6 -x,-y,z+1/2   
# 
loop_
_pdbx_refine_tls.id 
_pdbx_refine_tls.pdbx_refine_id 
_pdbx_refine_tls.details 
_pdbx_refine_tls.method 
_pdbx_refine_tls.origin_x 
_pdbx_refine_tls.origin_y 
_pdbx_refine_tls.origin_z 
_pdbx_refine_tls.T[1][1] 
_pdbx_refine_tls.T[1][1]_esd 
_pdbx_refine_tls.T[1][2] 
_pdbx_refine_tls.T[1][2]_esd 
_pdbx_refine_tls.T[1][3] 
_pdbx_refine_tls.T[1][3]_esd 
_pdbx_refine_tls.T[2][2] 
_pdbx_refine_tls.T[2][2]_esd 
_pdbx_refine_tls.T[2][3] 
_pdbx_refine_tls.T[2][3]_esd 
_pdbx_refine_tls.T[3][3] 
_pdbx_refine_tls.T[3][3]_esd 
_pdbx_refine_tls.L[1][1] 
_pdbx_refine_tls.L[1][1]_esd 
_pdbx_refine_tls.L[1][2] 
_pdbx_refine_tls.L[1][2]_esd 
_pdbx_refine_tls.L[1][3] 
_pdbx_refine_tls.L[1][3]_esd 
_pdbx_refine_tls.L[2][2] 
_pdbx_refine_tls.L[2][2]_esd 
_pdbx_refine_tls.L[2][3] 
_pdbx_refine_tls.L[2][3]_esd 
_pdbx_refine_tls.L[3][3] 
_pdbx_refine_tls.L[3][3]_esd 
_pdbx_refine_tls.S[1][1] 
_pdbx_refine_tls.S[1][1]_esd 
_pdbx_refine_tls.S[1][2] 
_pdbx_refine_tls.S[1][2]_esd 
_pdbx_refine_tls.S[1][3] 
_pdbx_refine_tls.S[1][3]_esd 
_pdbx_refine_tls.S[2][1] 
_pdbx_refine_tls.S[2][1]_esd 
_pdbx_refine_tls.S[2][2] 
_pdbx_refine_tls.S[2][2]_esd 
_pdbx_refine_tls.S[2][3] 
_pdbx_refine_tls.S[2][3]_esd 
_pdbx_refine_tls.S[3][1] 
_pdbx_refine_tls.S[3][1]_esd 
_pdbx_refine_tls.S[3][2] 
_pdbx_refine_tls.S[3][2]_esd 
_pdbx_refine_tls.S[3][3] 
_pdbx_refine_tls.S[3][3]_esd 
1 'X-RAY DIFFRACTION' ? refined 133.683169632 -11.0343430996 -12.6693964936  0.391575994261 ? 0.0656962978188  ? 0.0207833340322   
? 0.306050188484 ? 0.063288581522     ? 0.306866296333 ? 0.360345011994  ? 0.169600781493  ? 0.161769793221   ? 0.209595275081  ? 
0.297751918703  ? 0.455976984511  ? -0.0764046664354 ? 0.412402551754     ? 0.0308183563522  ? 0.0942079903074  ? 0.216330426677   
? 0.239279549256   ? -0.213694906063  ? -0.407697966693  ? 0.00857363123284   ? 
2 'X-RAY DIFFRACTION' ? refined 138.888151629 6.88729650296  4.9355910438    0.427401608026 ? -0.0326571365803 ? 0.031259963055    
? 0.183789412777 ? -0.0126060042808   ? 0.35563296522  ? 0.292502271417  ? 0.0160733178442 ? -0.331668858301  ? 0.219540103765  ? 
-0.264256473563 ? 1.34261529442   ? -0.023095048327  ? 0.0549198481732    ? 0.407732685589   ? -0.0500691239866 ? 0.0612161359943  
? -0.0369260481653 ? -0.492876981388  ? -0.171037278015  ? 0.124808516894     ? 
3 'X-RAY DIFFRACTION' ? refined 127.92784177  -3.86188121148 14.1538736719   0.358533639575 ? 0.0376999929474  ? 0.113655028563    
? 0.260120282849 ? 0.0207542150441    ? 0.285846893563 ? 0.0280449435196 ? 0.0176016790959 ? 0.0201015964504  ? 0.0750376939835 ? 
0.0360209105904 ? 0.0378217100616 ? 0.0696702132219  ? -0.237270939095    ? -0.0889594755508 ? 0.348077027285   ? 0.168576305999   
? 0.115762590799   ? -0.0942688379944 ? -0.154172426252  ? -0.000378050557474 ? 
4 'X-RAY DIFFRACTION' ? refined 141.74227462  -3.62780657253 3.19815958827   0.311891061138 ? -0.0315149848143 ? 0.0212253621793   
? 0.199450546047 ? -0.000905173912645 ? 0.264401818787 ? 0.217886931973  ? -0.209193862104 ? 0.265632012248   ? 0.485399280275  ? 
-0.276519254454 ? 0.515798320459  ? 0.0224022535031  ? -0.000765905362932 ? 0.238570575289   ? -0.0337719933303 ? 0.138469483701   
? -0.164244973848  ? -0.390135639612  ? 0.122491968461   ? 0.0186279558368    ? 
5 'X-RAY DIFFRACTION' ? refined 137.56714478  -21.0701964922 -0.936316284836 0.181947946486 ? -0.025023448711  ? -0.00531507917504 
? 0.179513404001 ? 0.0131235162104    ? 0.192734630733 ? 0.778011416085  ? -0.156589654337 ? -0.0700779780471 ? 0.823544935073  ? 
0.0217746520018 ? 1.69453426192   ? 0.0570832257861  ? 0.0287284511397    ? -0.0305395175146 ? 0.0458063833851  ? -0.0234522956135 
? 0.013240998146   ? 0.0735887109615  ? -0.0485602697846 ? -1.73606826319e-05 ? 
# 
loop_
_pdbx_refine_tls_group.id 
_pdbx_refine_tls_group.pdbx_refine_id 
_pdbx_refine_tls_group.refine_tls_id 
_pdbx_refine_tls_group.beg_label_asym_id 
_pdbx_refine_tls_group.beg_label_seq_id 
_pdbx_refine_tls_group.beg_auth_asym_id 
_pdbx_refine_tls_group.beg_auth_seq_id 
_pdbx_refine_tls_group.beg_PDB_ins_code 
_pdbx_refine_tls_group.end_label_asym_id 
_pdbx_refine_tls_group.end_label_seq_id 
_pdbx_refine_tls_group.end_auth_asym_id 
_pdbx_refine_tls_group.end_auth_seq_id 
_pdbx_refine_tls_group.end_PDB_ins_code 
_pdbx_refine_tls_group.selection 
_pdbx_refine_tls_group.selection_details 
1 'X-RAY DIFFRACTION' 1 C 1   B 2   ? C 9   B 10  ? ? 
;chain 'B' and (resid 2 through 10 )
;
2 'X-RAY DIFFRACTION' 2 A 1   A 33  ? A 41  A 73  ? ? 
;chain 'A' and (resid 33 through 73 )
;
3 'X-RAY DIFFRACTION' 3 A 42  A 74  ? A 64  A 96  ? ? 
;chain 'A' and (resid 74 through 96 )
;
4 'X-RAY DIFFRACTION' 4 A 65  A 97  ? A 108 A 140 ? ? 
;chain 'A' and (resid 97 through 140 )
;
5 'X-RAY DIFFRACTION' 5 A 109 A 141 ? A 273 A 305 ? ? 
;chain 'A' and (resid 141 through 305 )
;
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A SER 0   ? A SER 1   
2  1 Y 1 A MET 1   ? A MET 2   
3  1 Y 1 A LEU 2   ? A LEU 3   
4  1 Y 1 A LEU 3   ? A LEU 4   
5  1 Y 1 A SER 4   ? A SER 5   
6  1 Y 1 A LYS 5   ? A LYS 6   
7  1 Y 1 A ILE 6   ? A ILE 7   
8  1 Y 1 A ASN 7   ? A ASN 8   
9  1 Y 1 A SER 8   ? A SER 9   
10 1 Y 1 A LEU 9   ? A LEU 10  
11 1 Y 1 A ALA 10  ? A ALA 11  
12 1 Y 1 A HIS 11  ? A HIS 12  
13 1 Y 1 A LEU 12  ? A LEU 13  
14 1 Y 1 A ARG 13  ? A ARG 14  
15 1 Y 1 A ALA 14  ? A ALA 15  
16 1 Y 1 A ALA 15  ? A ALA 16  
17 1 Y 1 A PRO 16  ? A PRO 17  
18 1 Y 1 A CYS 17  ? A CYS 18  
19 1 Y 1 A ASN 18  ? A ASN 19  
20 1 Y 1 A ASP 19  ? A ASP 20  
21 1 Y 1 A LEU 20  ? A LEU 21  
22 1 Y 1 A HIS 21  ? A HIS 22  
23 1 Y 1 A ALA 22  ? A ALA 23  
24 1 Y 1 A THR 23  ? A THR 24  
25 1 Y 1 A LYS 24  ? A LYS 25  
26 1 Y 1 A LEU 25  ? A LEU 26  
27 1 Y 1 A ALA 26  ? A ALA 27  
28 1 Y 1 A PRO 27  ? A PRO 28  
29 1 Y 1 A GLY 28  ? A GLY 29  
30 1 Y 1 A LYS 29  ? A LYS 30  
31 1 Y 1 A GLU 30  ? A GLU 31  
32 1 Y 1 A LYS 31  ? A LYS 32  
33 1 Y 1 A GLU 32  ? A GLU 33  
34 1 Y 1 A SER 306 ? A SER 307 
35 1 Y 1 A LEU 307 ? A LEU 308 
36 1 Y 1 A SER 308 ? A SER 309 
37 1 Y 1 A PRO 309 ? A PRO 310 
38 1 Y 1 A GLY 310 ? A GLY 311 
39 1 Y 1 A PRO 311 ? A PRO 312 
40 1 Y 1 A SER 312 ? A SER 313 
41 1 Y 1 B ALA 1   ? B ALA 1   
42 1 Y 1 B PRO 11  ? B PRO 11  
43 1 Y 1 B PRO 12  ? B PRO 12  
44 1 Y 1 B THR 13  ? B THR 13  
45 1 Y 1 B ALA 14  ? B ALA 14  
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
8UB C4   C Y N 1   
8UB C5   C Y N 2   
8UB C6   C N N 3   
8UB N1   N N N 4   
8UB C7   C N N 5   
8UB C8   C N N 6   
8UB O    O N N 7   
8UB N    N N N 8   
8UB C    C Y N 9   
8UB C3   C Y N 10  
8UB C2   C Y N 11  
8UB C1   C Y N 12  
8UB H1   H N N 13  
8UB H2   H N N 14  
8UB H5   H N N 15  
8UB H6   H N N 16  
8UB H7   H N N 17  
8UB H8   H N N 18  
8UB C9   C N N 19  
8UB C10  C Y N 20  
8UB C11  C Y N 21  
8UB C12  C Y N 22  
8UB C13  C Y N 23  
8UB S1   S Y N 24  
8UB H3   H N N 25  
8UB H9   H N N 26  
8UB H11  H N N 27  
8UB H13  H N N 28  
ALA N    N N N 29  
ALA CA   C N S 30  
ALA C    C N N 31  
ALA O    O N N 32  
ALA CB   C N N 33  
ALA OXT  O N N 34  
ALA H    H N N 35  
ALA H2   H N N 36  
ALA HA   H N N 37  
ALA HB1  H N N 38  
ALA HB2  H N N 39  
ALA HB3  H N N 40  
ALA HXT  H N N 41  
ARG N    N N N 42  
ARG CA   C N S 43  
ARG C    C N N 44  
ARG O    O N N 45  
ARG CB   C N N 46  
ARG CG   C N N 47  
ARG CD   C N N 48  
ARG NE   N N N 49  
ARG CZ   C N N 50  
ARG NH1  N N N 51  
ARG NH2  N N N 52  
ARG OXT  O N N 53  
ARG H    H N N 54  
ARG H2   H N N 55  
ARG HA   H N N 56  
ARG HB2  H N N 57  
ARG HB3  H N N 58  
ARG HG2  H N N 59  
ARG HG3  H N N 60  
ARG HD2  H N N 61  
ARG HD3  H N N 62  
ARG HE   H N N 63  
ARG HH11 H N N 64  
ARG HH12 H N N 65  
ARG HH21 H N N 66  
ARG HH22 H N N 67  
ARG HXT  H N N 68  
ASN N    N N N 69  
ASN CA   C N S 70  
ASN C    C N N 71  
ASN O    O N N 72  
ASN CB   C N N 73  
ASN CG   C N N 74  
ASN OD1  O N N 75  
ASN ND2  N N N 76  
ASN OXT  O N N 77  
ASN H    H N N 78  
ASN H2   H N N 79  
ASN HA   H N N 80  
ASN HB2  H N N 81  
ASN HB3  H N N 82  
ASN HD21 H N N 83  
ASN HD22 H N N 84  
ASN HXT  H N N 85  
ASP N    N N N 86  
ASP CA   C N S 87  
ASP C    C N N 88  
ASP O    O N N 89  
ASP CB   C N N 90  
ASP CG   C N N 91  
ASP OD1  O N N 92  
ASP OD2  O N N 93  
ASP OXT  O N N 94  
ASP H    H N N 95  
ASP H2   H N N 96  
ASP HA   H N N 97  
ASP HB2  H N N 98  
ASP HB3  H N N 99  
ASP HD2  H N N 100 
ASP HXT  H N N 101 
CYS N    N N N 102 
CYS CA   C N R 103 
CYS C    C N N 104 
CYS O    O N N 105 
CYS CB   C N N 106 
CYS SG   S N N 107 
CYS OXT  O N N 108 
CYS H    H N N 109 
CYS H2   H N N 110 
CYS HA   H N N 111 
CYS HB2  H N N 112 
CYS HB3  H N N 113 
CYS HG   H N N 114 
CYS HXT  H N N 115 
GLN N    N N N 116 
GLN CA   C N S 117 
GLN C    C N N 118 
GLN O    O N N 119 
GLN CB   C N N 120 
GLN CG   C N N 121 
GLN CD   C N N 122 
GLN OE1  O N N 123 
GLN NE2  N N N 124 
GLN OXT  O N N 125 
GLN H    H N N 126 
GLN H2   H N N 127 
GLN HA   H N N 128 
GLN HB2  H N N 129 
GLN HB3  H N N 130 
GLN HG2  H N N 131 
GLN HG3  H N N 132 
GLN HE21 H N N 133 
GLN HE22 H N N 134 
GLN HXT  H N N 135 
GLU N    N N N 136 
GLU CA   C N S 137 
GLU C    C N N 138 
GLU O    O N N 139 
GLU CB   C N N 140 
GLU CG   C N N 141 
GLU CD   C N N 142 
GLU OE1  O N N 143 
GLU OE2  O N N 144 
GLU OXT  O N N 145 
GLU H    H N N 146 
GLU H2   H N N 147 
GLU HA   H N N 148 
GLU HB2  H N N 149 
GLU HB3  H N N 150 
GLU HG2  H N N 151 
GLU HG3  H N N 152 
GLU HE2  H N N 153 
GLU HXT  H N N 154 
GLY N    N N N 155 
GLY CA   C N N 156 
GLY C    C N N 157 
GLY O    O N N 158 
GLY OXT  O N N 159 
GLY H    H N N 160 
GLY H2   H N N 161 
GLY HA2  H N N 162 
GLY HA3  H N N 163 
GLY HXT  H N N 164 
GOL C1   C N N 165 
GOL O1   O N N 166 
GOL C2   C N N 167 
GOL O2   O N N 168 
GOL C3   C N N 169 
GOL O3   O N N 170 
GOL H11  H N N 171 
GOL H12  H N N 172 
GOL HO1  H N N 173 
GOL H2   H N N 174 
GOL HO2  H N N 175 
GOL H31  H N N 176 
GOL H32  H N N 177 
GOL HO3  H N N 178 
HIS N    N N N 179 
HIS CA   C N S 180 
HIS C    C N N 181 
HIS O    O N N 182 
HIS CB   C N N 183 
HIS CG   C Y N 184 
HIS ND1  N Y N 185 
HIS CD2  C Y N 186 
HIS CE1  C Y N 187 
HIS NE2  N Y N 188 
HIS OXT  O N N 189 
HIS H    H N N 190 
HIS H2   H N N 191 
HIS HA   H N N 192 
HIS HB2  H N N 193 
HIS HB3  H N N 194 
HIS HD1  H N N 195 
HIS HD2  H N N 196 
HIS HE1  H N N 197 
HIS HE2  H N N 198 
HIS HXT  H N N 199 
HOH O    O N N 200 
HOH H1   H N N 201 
HOH H2   H N N 202 
ILE N    N N N 203 
ILE CA   C N S 204 
ILE C    C N N 205 
ILE O    O N N 206 
ILE CB   C N S 207 
ILE CG1  C N N 208 
ILE CG2  C N N 209 
ILE CD1  C N N 210 
ILE OXT  O N N 211 
ILE H    H N N 212 
ILE H2   H N N 213 
ILE HA   H N N 214 
ILE HB   H N N 215 
ILE HG12 H N N 216 
ILE HG13 H N N 217 
ILE HG21 H N N 218 
ILE HG22 H N N 219 
ILE HG23 H N N 220 
ILE HD11 H N N 221 
ILE HD12 H N N 222 
ILE HD13 H N N 223 
ILE HXT  H N N 224 
LEU N    N N N 225 
LEU CA   C N S 226 
LEU C    C N N 227 
LEU O    O N N 228 
LEU CB   C N N 229 
LEU CG   C N N 230 
LEU CD1  C N N 231 
LEU CD2  C N N 232 
LEU OXT  O N N 233 
LEU H    H N N 234 
LEU H2   H N N 235 
LEU HA   H N N 236 
LEU HB2  H N N 237 
LEU HB3  H N N 238 
LEU HG   H N N 239 
LEU HD11 H N N 240 
LEU HD12 H N N 241 
LEU HD13 H N N 242 
LEU HD21 H N N 243 
LEU HD22 H N N 244 
LEU HD23 H N N 245 
LEU HXT  H N N 246 
LYS N    N N N 247 
LYS CA   C N S 248 
LYS C    C N N 249 
LYS O    O N N 250 
LYS CB   C N N 251 
LYS CG   C N N 252 
LYS CD   C N N 253 
LYS CE   C N N 254 
LYS NZ   N N N 255 
LYS OXT  O N N 256 
LYS H    H N N 257 
LYS H2   H N N 258 
LYS HA   H N N 259 
LYS HB2  H N N 260 
LYS HB3  H N N 261 
LYS HG2  H N N 262 
LYS HG3  H N N 263 
LYS HD2  H N N 264 
LYS HD3  H N N 265 
LYS HE2  H N N 266 
LYS HE3  H N N 267 
LYS HZ1  H N N 268 
LYS HZ2  H N N 269 
LYS HZ3  H N N 270 
LYS HXT  H N N 271 
MET N    N N N 272 
MET CA   C N S 273 
MET C    C N N 274 
MET O    O N N 275 
MET CB   C N N 276 
MET CG   C N N 277 
MET SD   S N N 278 
MET CE   C N N 279 
MET OXT  O N N 280 
MET H    H N N 281 
MET H2   H N N 282 
MET HA   H N N 283 
MET HB2  H N N 284 
MET HB3  H N N 285 
MET HG2  H N N 286 
MET HG3  H N N 287 
MET HE1  H N N 288 
MET HE2  H N N 289 
MET HE3  H N N 290 
MET HXT  H N N 291 
PHE N    N N N 292 
PHE CA   C N S 293 
PHE C    C N N 294 
PHE O    O N N 295 
PHE CB   C N N 296 
PHE CG   C Y N 297 
PHE CD1  C Y N 298 
PHE CD2  C Y N 299 
PHE CE1  C Y N 300 
PHE CE2  C Y N 301 
PHE CZ   C Y N 302 
PHE OXT  O N N 303 
PHE H    H N N 304 
PHE H2   H N N 305 
PHE HA   H N N 306 
PHE HB2  H N N 307 
PHE HB3  H N N 308 
PHE HD1  H N N 309 
PHE HD2  H N N 310 
PHE HE1  H N N 311 
PHE HE2  H N N 312 
PHE HZ   H N N 313 
PHE HXT  H N N 314 
PRO N    N N N 315 
PRO CA   C N S 316 
PRO C    C N N 317 
PRO O    O N N 318 
PRO CB   C N N 319 
PRO CG   C N N 320 
PRO CD   C N N 321 
PRO OXT  O N N 322 
PRO H    H N N 323 
PRO HA   H N N 324 
PRO HB2  H N N 325 
PRO HB3  H N N 326 
PRO HG2  H N N 327 
PRO HG3  H N N 328 
PRO HD2  H N N 329 
PRO HD3  H N N 330 
PRO HXT  H N N 331 
SEP N    N N N 332 
SEP CA   C N S 333 
SEP CB   C N N 334 
SEP OG   O N N 335 
SEP C    C N N 336 
SEP O    O N N 337 
SEP OXT  O N N 338 
SEP P    P N N 339 
SEP O1P  O N N 340 
SEP O2P  O N N 341 
SEP O3P  O N N 342 
SEP H    H N N 343 
SEP H2   H N N 344 
SEP HA   H N N 345 
SEP HB2  H N N 346 
SEP HB3  H N N 347 
SEP HXT  H N N 348 
SEP HOP2 H N N 349 
SEP HOP3 H N N 350 
SER N    N N N 351 
SER CA   C N S 352 
SER C    C N N 353 
SER O    O N N 354 
SER CB   C N N 355 
SER OG   O N N 356 
SER OXT  O N N 357 
SER H    H N N 358 
SER H2   H N N 359 
SER HA   H N N 360 
SER HB2  H N N 361 
SER HB3  H N N 362 
SER HG   H N N 363 
SER HXT  H N N 364 
THR N    N N N 365 
THR CA   C N S 366 
THR C    C N N 367 
THR O    O N N 368 
THR CB   C N R 369 
THR OG1  O N N 370 
THR CG2  C N N 371 
THR OXT  O N N 372 
THR H    H N N 373 
THR H2   H N N 374 
THR HA   H N N 375 
THR HB   H N N 376 
THR HG1  H N N 377 
THR HG21 H N N 378 
THR HG22 H N N 379 
THR HG23 H N N 380 
THR HXT  H N N 381 
TRP N    N N N 382 
TRP CA   C N S 383 
TRP C    C N N 384 
TRP O    O N N 385 
TRP CB   C N N 386 
TRP CG   C Y N 387 
TRP CD1  C Y N 388 
TRP CD2  C Y N 389 
TRP NE1  N Y N 390 
TRP CE2  C Y N 391 
TRP CE3  C Y N 392 
TRP CZ2  C Y N 393 
TRP CZ3  C Y N 394 
TRP CH2  C Y N 395 
TRP OXT  O N N 396 
TRP H    H N N 397 
TRP H2   H N N 398 
TRP HA   H N N 399 
TRP HB2  H N N 400 
TRP HB3  H N N 401 
TRP HD1  H N N 402 
TRP HE1  H N N 403 
TRP HE3  H N N 404 
TRP HZ2  H N N 405 
TRP HZ3  H N N 406 
TRP HH2  H N N 407 
TRP HXT  H N N 408 
TYR N    N N N 409 
TYR CA   C N S 410 
TYR C    C N N 411 
TYR O    O N N 412 
TYR CB   C N N 413 
TYR CG   C Y N 414 
TYR CD1  C Y N 415 
TYR CD2  C Y N 416 
TYR CE1  C Y N 417 
TYR CE2  C Y N 418 
TYR CZ   C Y N 419 
TYR OH   O N N 420 
TYR OXT  O N N 421 
TYR H    H N N 422 
TYR H2   H N N 423 
TYR HA   H N N 424 
TYR HB2  H N N 425 
TYR HB3  H N N 426 
TYR HD1  H N N 427 
TYR HD2  H N N 428 
TYR HE1  H N N 429 
TYR HE2  H N N 430 
TYR HH   H N N 431 
TYR HXT  H N N 432 
VAL N    N N N 433 
VAL CA   C N S 434 
VAL C    C N N 435 
VAL O    O N N 436 
VAL CB   C N N 437 
VAL CG1  C N N 438 
VAL CG2  C N N 439 
VAL OXT  O N N 440 
VAL H    H N N 441 
VAL H2   H N N 442 
VAL HA   H N N 443 
VAL HB   H N N 444 
VAL HG11 H N N 445 
VAL HG12 H N N 446 
VAL HG13 H N N 447 
VAL HG21 H N N 448 
VAL HG22 H N N 449 
VAL HG23 H N N 450 
VAL HXT  H N N 451 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
8UB C8  C7   sing N N 1   
8UB N1  C7   doub N N 2   
8UB N1  C3   sing N N 3   
8UB C2  C3   doub Y N 4   
8UB C2  C1   sing Y N 5   
8UB C7  C6   sing N N 6   
8UB C3  C4   sing Y N 7   
8UB C1  C    doub Y N 8   
8UB C6  O    doub N N 9   
8UB C6  N    sing N N 10  
8UB C4  N    sing N N 11  
8UB C4  C5   doub Y N 12  
8UB C   C5   sing Y N 13  
8UB C5  H1   sing N N 14  
8UB C8  H2   sing N N 15  
8UB N   H5   sing N N 16  
8UB C   H6   sing N N 17  
8UB C2  H7   sing N N 18  
8UB C1  H8   sing N N 19  
8UB C8  C9   doub N N 20  
8UB C9  C10  sing N N 21  
8UB C10 C11  doub Y N 22  
8UB C11 C12  sing Y N 23  
8UB C12 C13  doub Y N 24  
8UB C10 S1   sing Y N 25  
8UB C9  H3   sing N N 26  
8UB C11 H9   sing N N 27  
8UB C12 H11  sing N N 28  
8UB C13 H13  sing N N 29  
8UB C13 S1   sing Y N 30  
ALA N   CA   sing N N 31  
ALA N   H    sing N N 32  
ALA N   H2   sing N N 33  
ALA CA  C    sing N N 34  
ALA CA  CB   sing N N 35  
ALA CA  HA   sing N N 36  
ALA C   O    doub N N 37  
ALA C   OXT  sing N N 38  
ALA CB  HB1  sing N N 39  
ALA CB  HB2  sing N N 40  
ALA CB  HB3  sing N N 41  
ALA OXT HXT  sing N N 42  
ARG N   CA   sing N N 43  
ARG N   H    sing N N 44  
ARG N   H2   sing N N 45  
ARG CA  C    sing N N 46  
ARG CA  CB   sing N N 47  
ARG CA  HA   sing N N 48  
ARG C   O    doub N N 49  
ARG C   OXT  sing N N 50  
ARG CB  CG   sing N N 51  
ARG CB  HB2  sing N N 52  
ARG CB  HB3  sing N N 53  
ARG CG  CD   sing N N 54  
ARG CG  HG2  sing N N 55  
ARG CG  HG3  sing N N 56  
ARG CD  NE   sing N N 57  
ARG CD  HD2  sing N N 58  
ARG CD  HD3  sing N N 59  
ARG NE  CZ   sing N N 60  
ARG NE  HE   sing N N 61  
ARG CZ  NH1  sing N N 62  
ARG CZ  NH2  doub N N 63  
ARG NH1 HH11 sing N N 64  
ARG NH1 HH12 sing N N 65  
ARG NH2 HH21 sing N N 66  
ARG NH2 HH22 sing N N 67  
ARG OXT HXT  sing N N 68  
ASN N   CA   sing N N 69  
ASN N   H    sing N N 70  
ASN N   H2   sing N N 71  
ASN CA  C    sing N N 72  
ASN CA  CB   sing N N 73  
ASN CA  HA   sing N N 74  
ASN C   O    doub N N 75  
ASN C   OXT  sing N N 76  
ASN CB  CG   sing N N 77  
ASN CB  HB2  sing N N 78  
ASN CB  HB3  sing N N 79  
ASN CG  OD1  doub N N 80  
ASN CG  ND2  sing N N 81  
ASN ND2 HD21 sing N N 82  
ASN ND2 HD22 sing N N 83  
ASN OXT HXT  sing N N 84  
ASP N   CA   sing N N 85  
ASP N   H    sing N N 86  
ASP N   H2   sing N N 87  
ASP CA  C    sing N N 88  
ASP CA  CB   sing N N 89  
ASP CA  HA   sing N N 90  
ASP C   O    doub N N 91  
ASP C   OXT  sing N N 92  
ASP CB  CG   sing N N 93  
ASP CB  HB2  sing N N 94  
ASP CB  HB3  sing N N 95  
ASP CG  OD1  doub N N 96  
ASP CG  OD2  sing N N 97  
ASP OD2 HD2  sing N N 98  
ASP OXT HXT  sing N N 99  
CYS N   CA   sing N N 100 
CYS N   H    sing N N 101 
CYS N   H2   sing N N 102 
CYS CA  C    sing N N 103 
CYS CA  CB   sing N N 104 
CYS CA  HA   sing N N 105 
CYS C   O    doub N N 106 
CYS C   OXT  sing N N 107 
CYS CB  SG   sing N N 108 
CYS CB  HB2  sing N N 109 
CYS CB  HB3  sing N N 110 
CYS SG  HG   sing N N 111 
CYS OXT HXT  sing N N 112 
GLN N   CA   sing N N 113 
GLN N   H    sing N N 114 
GLN N   H2   sing N N 115 
GLN CA  C    sing N N 116 
GLN CA  CB   sing N N 117 
GLN CA  HA   sing N N 118 
GLN C   O    doub N N 119 
GLN C   OXT  sing N N 120 
GLN CB  CG   sing N N 121 
GLN CB  HB2  sing N N 122 
GLN CB  HB3  sing N N 123 
GLN CG  CD   sing N N 124 
GLN CG  HG2  sing N N 125 
GLN CG  HG3  sing N N 126 
GLN CD  OE1  doub N N 127 
GLN CD  NE2  sing N N 128 
GLN NE2 HE21 sing N N 129 
GLN NE2 HE22 sing N N 130 
GLN OXT HXT  sing N N 131 
GLU N   CA   sing N N 132 
GLU N   H    sing N N 133 
GLU N   H2   sing N N 134 
GLU CA  C    sing N N 135 
GLU CA  CB   sing N N 136 
GLU CA  HA   sing N N 137 
GLU C   O    doub N N 138 
GLU C   OXT  sing N N 139 
GLU CB  CG   sing N N 140 
GLU CB  HB2  sing N N 141 
GLU CB  HB3  sing N N 142 
GLU CG  CD   sing N N 143 
GLU CG  HG2  sing N N 144 
GLU CG  HG3  sing N N 145 
GLU CD  OE1  doub N N 146 
GLU CD  OE2  sing N N 147 
GLU OE2 HE2  sing N N 148 
GLU OXT HXT  sing N N 149 
GLY N   CA   sing N N 150 
GLY N   H    sing N N 151 
GLY N   H2   sing N N 152 
GLY CA  C    sing N N 153 
GLY CA  HA2  sing N N 154 
GLY CA  HA3  sing N N 155 
GLY C   O    doub N N 156 
GLY C   OXT  sing N N 157 
GLY OXT HXT  sing N N 158 
GOL C1  O1   sing N N 159 
GOL C1  C2   sing N N 160 
GOL C1  H11  sing N N 161 
GOL C1  H12  sing N N 162 
GOL O1  HO1  sing N N 163 
GOL C2  O2   sing N N 164 
GOL C2  C3   sing N N 165 
GOL C2  H2   sing N N 166 
GOL O2  HO2  sing N N 167 
GOL C3  O3   sing N N 168 
GOL C3  H31  sing N N 169 
GOL C3  H32  sing N N 170 
GOL O3  HO3  sing N N 171 
HIS N   CA   sing N N 172 
HIS N   H    sing N N 173 
HIS N   H2   sing N N 174 
HIS CA  C    sing N N 175 
HIS CA  CB   sing N N 176 
HIS CA  HA   sing N N 177 
HIS C   O    doub N N 178 
HIS C   OXT  sing N N 179 
HIS CB  CG   sing N N 180 
HIS CB  HB2  sing N N 181 
HIS CB  HB3  sing N N 182 
HIS CG  ND1  sing Y N 183 
HIS CG  CD2  doub Y N 184 
HIS ND1 CE1  doub Y N 185 
HIS ND1 HD1  sing N N 186 
HIS CD2 NE2  sing Y N 187 
HIS CD2 HD2  sing N N 188 
HIS CE1 NE2  sing Y N 189 
HIS CE1 HE1  sing N N 190 
HIS NE2 HE2  sing N N 191 
HIS OXT HXT  sing N N 192 
HOH O   H1   sing N N 193 
HOH O   H2   sing N N 194 
ILE N   CA   sing N N 195 
ILE N   H    sing N N 196 
ILE N   H2   sing N N 197 
ILE CA  C    sing N N 198 
ILE CA  CB   sing N N 199 
ILE CA  HA   sing N N 200 
ILE C   O    doub N N 201 
ILE C   OXT  sing N N 202 
ILE CB  CG1  sing N N 203 
ILE CB  CG2  sing N N 204 
ILE CB  HB   sing N N 205 
ILE CG1 CD1  sing N N 206 
ILE CG1 HG12 sing N N 207 
ILE CG1 HG13 sing N N 208 
ILE CG2 HG21 sing N N 209 
ILE CG2 HG22 sing N N 210 
ILE CG2 HG23 sing N N 211 
ILE CD1 HD11 sing N N 212 
ILE CD1 HD12 sing N N 213 
ILE CD1 HD13 sing N N 214 
ILE OXT HXT  sing N N 215 
LEU N   CA   sing N N 216 
LEU N   H    sing N N 217 
LEU N   H2   sing N N 218 
LEU CA  C    sing N N 219 
LEU CA  CB   sing N N 220 
LEU CA  HA   sing N N 221 
LEU C   O    doub N N 222 
LEU C   OXT  sing N N 223 
LEU CB  CG   sing N N 224 
LEU CB  HB2  sing N N 225 
LEU CB  HB3  sing N N 226 
LEU CG  CD1  sing N N 227 
LEU CG  CD2  sing N N 228 
LEU CG  HG   sing N N 229 
LEU CD1 HD11 sing N N 230 
LEU CD1 HD12 sing N N 231 
LEU CD1 HD13 sing N N 232 
LEU CD2 HD21 sing N N 233 
LEU CD2 HD22 sing N N 234 
LEU CD2 HD23 sing N N 235 
LEU OXT HXT  sing N N 236 
LYS N   CA   sing N N 237 
LYS N   H    sing N N 238 
LYS N   H2   sing N N 239 
LYS CA  C    sing N N 240 
LYS CA  CB   sing N N 241 
LYS CA  HA   sing N N 242 
LYS C   O    doub N N 243 
LYS C   OXT  sing N N 244 
LYS CB  CG   sing N N 245 
LYS CB  HB2  sing N N 246 
LYS CB  HB3  sing N N 247 
LYS CG  CD   sing N N 248 
LYS CG  HG2  sing N N 249 
LYS CG  HG3  sing N N 250 
LYS CD  CE   sing N N 251 
LYS CD  HD2  sing N N 252 
LYS CD  HD3  sing N N 253 
LYS CE  NZ   sing N N 254 
LYS CE  HE2  sing N N 255 
LYS CE  HE3  sing N N 256 
LYS NZ  HZ1  sing N N 257 
LYS NZ  HZ2  sing N N 258 
LYS NZ  HZ3  sing N N 259 
LYS OXT HXT  sing N N 260 
MET N   CA   sing N N 261 
MET N   H    sing N N 262 
MET N   H2   sing N N 263 
MET CA  C    sing N N 264 
MET CA  CB   sing N N 265 
MET CA  HA   sing N N 266 
MET C   O    doub N N 267 
MET C   OXT  sing N N 268 
MET CB  CG   sing N N 269 
MET CB  HB2  sing N N 270 
MET CB  HB3  sing N N 271 
MET CG  SD   sing N N 272 
MET CG  HG2  sing N N 273 
MET CG  HG3  sing N N 274 
MET SD  CE   sing N N 275 
MET CE  HE1  sing N N 276 
MET CE  HE2  sing N N 277 
MET CE  HE3  sing N N 278 
MET OXT HXT  sing N N 279 
PHE N   CA   sing N N 280 
PHE N   H    sing N N 281 
PHE N   H2   sing N N 282 
PHE CA  C    sing N N 283 
PHE CA  CB   sing N N 284 
PHE CA  HA   sing N N 285 
PHE C   O    doub N N 286 
PHE C   OXT  sing N N 287 
PHE CB  CG   sing N N 288 
PHE CB  HB2  sing N N 289 
PHE CB  HB3  sing N N 290 
PHE CG  CD1  doub Y N 291 
PHE CG  CD2  sing Y N 292 
PHE CD1 CE1  sing Y N 293 
PHE CD1 HD1  sing N N 294 
PHE CD2 CE2  doub Y N 295 
PHE CD2 HD2  sing N N 296 
PHE CE1 CZ   doub Y N 297 
PHE CE1 HE1  sing N N 298 
PHE CE2 CZ   sing Y N 299 
PHE CE2 HE2  sing N N 300 
PHE CZ  HZ   sing N N 301 
PHE OXT HXT  sing N N 302 
PRO N   CA   sing N N 303 
PRO N   CD   sing N N 304 
PRO N   H    sing N N 305 
PRO CA  C    sing N N 306 
PRO CA  CB   sing N N 307 
PRO CA  HA   sing N N 308 
PRO C   O    doub N N 309 
PRO C   OXT  sing N N 310 
PRO CB  CG   sing N N 311 
PRO CB  HB2  sing N N 312 
PRO CB  HB3  sing N N 313 
PRO CG  CD   sing N N 314 
PRO CG  HG2  sing N N 315 
PRO CG  HG3  sing N N 316 
PRO CD  HD2  sing N N 317 
PRO CD  HD3  sing N N 318 
PRO OXT HXT  sing N N 319 
SEP N   CA   sing N N 320 
SEP N   H    sing N N 321 
SEP N   H2   sing N N 322 
SEP CA  CB   sing N N 323 
SEP CA  C    sing N N 324 
SEP CA  HA   sing N N 325 
SEP CB  OG   sing N N 326 
SEP CB  HB2  sing N N 327 
SEP CB  HB3  sing N N 328 
SEP OG  P    sing N N 329 
SEP C   O    doub N N 330 
SEP C   OXT  sing N N 331 
SEP OXT HXT  sing N N 332 
SEP P   O1P  doub N N 333 
SEP P   O2P  sing N N 334 
SEP P   O3P  sing N N 335 
SEP O2P HOP2 sing N N 336 
SEP O3P HOP3 sing N N 337 
SER N   CA   sing N N 338 
SER N   H    sing N N 339 
SER N   H2   sing N N 340 
SER CA  C    sing N N 341 
SER CA  CB   sing N N 342 
SER CA  HA   sing N N 343 
SER C   O    doub N N 344 
SER C   OXT  sing N N 345 
SER CB  OG   sing N N 346 
SER CB  HB2  sing N N 347 
SER CB  HB3  sing N N 348 
SER OG  HG   sing N N 349 
SER OXT HXT  sing N N 350 
THR N   CA   sing N N 351 
THR N   H    sing N N 352 
THR N   H2   sing N N 353 
THR CA  C    sing N N 354 
THR CA  CB   sing N N 355 
THR CA  HA   sing N N 356 
THR C   O    doub N N 357 
THR C   OXT  sing N N 358 
THR CB  OG1  sing N N 359 
THR CB  CG2  sing N N 360 
THR CB  HB   sing N N 361 
THR OG1 HG1  sing N N 362 
THR CG2 HG21 sing N N 363 
THR CG2 HG22 sing N N 364 
THR CG2 HG23 sing N N 365 
THR OXT HXT  sing N N 366 
TRP N   CA   sing N N 367 
TRP N   H    sing N N 368 
TRP N   H2   sing N N 369 
TRP CA  C    sing N N 370 
TRP CA  CB   sing N N 371 
TRP CA  HA   sing N N 372 
TRP C   O    doub N N 373 
TRP C   OXT  sing N N 374 
TRP CB  CG   sing N N 375 
TRP CB  HB2  sing N N 376 
TRP CB  HB3  sing N N 377 
TRP CG  CD1  doub Y N 378 
TRP CG  CD2  sing Y N 379 
TRP CD1 NE1  sing Y N 380 
TRP CD1 HD1  sing N N 381 
TRP CD2 CE2  doub Y N 382 
TRP CD2 CE3  sing Y N 383 
TRP NE1 CE2  sing Y N 384 
TRP NE1 HE1  sing N N 385 
TRP CE2 CZ2  sing Y N 386 
TRP CE3 CZ3  doub Y N 387 
TRP CE3 HE3  sing N N 388 
TRP CZ2 CH2  doub Y N 389 
TRP CZ2 HZ2  sing N N 390 
TRP CZ3 CH2  sing Y N 391 
TRP CZ3 HZ3  sing N N 392 
TRP CH2 HH2  sing N N 393 
TRP OXT HXT  sing N N 394 
TYR N   CA   sing N N 395 
TYR N   H    sing N N 396 
TYR N   H2   sing N N 397 
TYR CA  C    sing N N 398 
TYR CA  CB   sing N N 399 
TYR CA  HA   sing N N 400 
TYR C   O    doub N N 401 
TYR C   OXT  sing N N 402 
TYR CB  CG   sing N N 403 
TYR CB  HB2  sing N N 404 
TYR CB  HB3  sing N N 405 
TYR CG  CD1  doub Y N 406 
TYR CG  CD2  sing Y N 407 
TYR CD1 CE1  sing Y N 408 
TYR CD1 HD1  sing N N 409 
TYR CD2 CE2  doub Y N 410 
TYR CD2 HD2  sing N N 411 
TYR CE1 CZ   doub Y N 412 
TYR CE1 HE1  sing N N 413 
TYR CE2 CZ   sing Y N 414 
TYR CE2 HE2  sing N N 415 
TYR CZ  OH   sing N N 416 
TYR OH  HH   sing N N 417 
TYR OXT HXT  sing N N 418 
VAL N   CA   sing N N 419 
VAL N   H    sing N N 420 
VAL N   H2   sing N N 421 
VAL CA  C    sing N N 422 
VAL CA  CB   sing N N 423 
VAL CA  HA   sing N N 424 
VAL C   O    doub N N 425 
VAL C   OXT  sing N N 426 
VAL CB  CG1  sing N N 427 
VAL CB  CG2  sing N N 428 
VAL CB  HB   sing N N 429 
VAL CG1 HG11 sing N N 430 
VAL CG1 HG12 sing N N 431 
VAL CG1 HG13 sing N N 432 
VAL CG2 HG21 sing N N 433 
VAL CG2 HG22 sing N N 434 
VAL CG2 HG23 sing N N 435 
VAL OXT HXT  sing N N 436 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   5NDT 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 65' 
_space_group.name_Hall        'P 65' 
_space_group.IT_number        170 
_space_group.crystal_system   hexagonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    8R0H 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.010173 
_atom_sites.fract_transf_matrix[1][2]   0.005873 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.011746 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.012447 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
P ? ? 9.51135 5.44231 ? ? 1.42069  35.72801 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . PRO A 1 34  ? 137.32461 13.91443  16.29757  1.000 70.41631  ? 33  PRO A N   1 
ATOM   2    C CA  . PRO A 1 34  ? 136.75620 14.28427  14.99591  1.000 79.87372  ? 33  PRO A CA  1 
ATOM   3    C C   . PRO A 1 34  ? 137.58399 13.75384  13.82786  1.000 77.25698  ? 33  PRO A C   1 
ATOM   4    O O   . PRO A 1 34  ? 138.80108 13.94379  13.78823  1.000 73.98032  ? 33  PRO A O   1 
ATOM   5    C CB  . PRO A 1 34  ? 136.76530 15.81627  15.02815  1.000 80.11472  ? 33  PRO A CB  1 
ATOM   6    C CG  . PRO A 1 34  ? 137.84587 16.16426  15.98700  1.000 84.98029  ? 33  PRO A CG  1 
ATOM   7    C CD  . PRO A 1 34  ? 137.83413 15.08444  17.03225  1.000 82.06766  ? 33  PRO A CD  1 
ATOM   8    N N   . LEU A 1 35  ? 136.90348 13.10325  12.88049  1.000 72.89960  ? 34  LEU A N   1 
ATOM   9    C CA  . LEU A 1 35  ? 137.58691 12.41898  11.78533  1.000 70.69464  ? 34  LEU A CA  1 
ATOM   10   C C   . LEU A 1 35  ? 138.36443 13.38218  10.89413  1.000 68.07095  ? 34  LEU A C   1 
ATOM   11   O O   . LEU A 1 35  ? 139.43960 13.03465  10.38684  1.000 57.00798  ? 34  LEU A O   1 
ATOM   12   C CB  . LEU A 1 35  ? 136.56124 11.63947  10.96051  1.000 67.49889  ? 34  LEU A CB  1 
ATOM   13   C CG  . LEU A 1 35  ? 136.86873 11.34947  9.49344   1.000 61.55450  ? 34  LEU A CG  1 
ATOM   14   C CD1 . LEU A 1 35  ? 137.93438 10.27095  9.36281   1.000 55.73097  ? 34  LEU A CD1 1 
ATOM   15   C CD2 . LEU A 1 35  ? 135.59543 10.95704  8.76875   1.000 59.94361  ? 34  LEU A CD2 1 
ATOM   16   N N   . GLU A 1 36  ? 137.85053 14.59475  10.70124  1.000 70.39970  ? 35  GLU A N   1 
ATOM   17   C CA  . GLU A 1 36  ? 138.43112 15.49344  9.71343   1.000 72.84095  ? 35  GLU A CA  1 
ATOM   18   C C   . GLU A 1 36  ? 139.83946 15.95128  10.08436  1.000 70.59600  ? 35  GLU A C   1 
ATOM   19   O O   . GLU A 1 36  ? 140.61855 16.29539  9.18740   1.000 69.14044  ? 35  GLU A O   1 
ATOM   20   C CB  . GLU A 1 36  ? 137.50764 16.69669  9.51016   1.000 71.32142  ? 35  GLU A CB  1 
ATOM   21   C CG  . GLU A 1 36  ? 136.13453 16.33934  8.93744   1.000 69.77623  ? 35  GLU A CG  1 
ATOM   22   C CD  . GLU A 1 36  ? 135.19025 15.74357  9.96767   1.000 63.25516  ? 35  GLU A CD  1 
ATOM   23   N N   . SER A 1 37  ? 140.19425 15.94090  11.37336  1.000 71.98927  ? 36  SER A N   1 
ATOM   24   C CA  . SER A 1 37  ? 141.50101 16.41827  11.81652  1.000 73.25923  ? 36  SER A CA  1 
ATOM   25   C C   . SER A 1 37  ? 142.49788 15.30321  12.11813  1.000 68.27402  ? 36  SER A C   1 
ATOM   26   O O   . SER A 1 37  ? 143.70376 15.57163  12.15873  1.000 65.28692  ? 36  SER A O   1 
ATOM   27   C CB  . SER A 1 37  ? 141.35321 17.30222  13.06354  1.000 74.08671  ? 36  SER A CB  1 
ATOM   28   O OG  . SER A 1 37  ? 140.88403 16.55537  14.17375  1.000 73.14124  ? 36  SER A OG  1 
ATOM   29   N N   . GLN A 1 38  ? 142.03636 14.06834  12.33343  1.000 64.98190  ? 37  GLN A N   1 
ATOM   30   C CA  . GLN A 1 38  ? 142.95101 12.96990  12.61971  1.000 55.01684  ? 37  GLN A CA  1 
ATOM   31   C C   . GLN A 1 38  ? 143.54134 12.34244  11.36538  1.000 49.99965  ? 37  GLN A C   1 
ATOM   32   O O   . GLN A 1 38  ? 144.58656 11.68878  11.45162  1.000 45.18298  ? 37  GLN A O   1 
ATOM   33   C CB  . GLN A 1 38  ? 142.24678 11.87794  13.42270  1.000 54.09125  ? 37  GLN A CB  1 
ATOM   34   C CG  . GLN A 1 38  ? 141.90903 12.23938  14.84472  1.000 61.14889  ? 37  GLN A CG  1 
ATOM   35   C CD  . GLN A 1 38  ? 141.37194 11.04739  15.61116  1.000 64.89380  ? 37  GLN A CD  1 
ATOM   36   O OE1 . GLN A 1 38  ? 140.22081 11.04254  16.04585  1.000 72.15654  ? 37  GLN A OE1 1 
ATOM   37   N NE2 . GLN A 1 38  ? 142.20385 10.02219  15.77220  1.000 57.60107  ? 37  GLN A NE2 1 
ATOM   38   N N   . TYR A 1 39  ? 142.90317 12.51057  10.21003  1.000 55.60244  ? 38  TYR A N   1 
ATOM   39   C CA  . TYR A 1 39  ? 143.31884 11.81540  8.99992   1.000 51.97707  ? 38  TYR A CA  1 
ATOM   40   C C   . TYR A 1 39  ? 143.40143 12.77830  7.83027   1.000 54.72225  ? 38  TYR A C   1 
ATOM   41   O O   . TYR A 1 39  ? 142.54635 13.65500  7.67128   1.000 55.65609  ? 38  TYR A O   1 
ATOM   42   C CB  . TYR A 1 39  ? 142.35532 10.66831  8.66544   1.000 45.34542  ? 38  TYR A CB  1 
ATOM   43   C CG  . TYR A 1 39  ? 142.30823 9.65338   9.76543   1.000 42.81983  ? 38  TYR A CG  1 
ATOM   44   C CD1 . TYR A 1 39  ? 143.25108 8.63475   9.83202   1.000 42.30732  ? 38  TYR A CD1 1 
ATOM   45   C CD2 . TYR A 1 39  ? 141.34706 9.72761   10.76139  1.000 43.42237  ? 38  TYR A CD2 1 
ATOM   46   C CE1 . TYR A 1 39  ? 143.23094 7.71292   10.85459  1.000 38.24398  ? 38  TYR A CE1 1 
ATOM   47   C CE2 . TYR A 1 39  ? 141.31753 8.80755   11.78798  1.000 43.19344  ? 38  TYR A CE2 1 
ATOM   48   C CZ  . TYR A 1 39  ? 142.26263 7.80428   11.82979  1.000 39.50099  ? 38  TYR A CZ  1 
ATOM   49   O OH  . TYR A 1 39  ? 142.23792 6.88784   12.85155  1.000 41.97923  ? 38  TYR A OH  1 
ATOM   50   N N   . GLN A 1 40  ? 144.44221 12.60783  7.02168   1.000 50.92700  ? 39  GLN A N   1 
ATOM   51   C CA  . GLN A 1 40  ? 144.56402 13.27703  5.73583   1.000 49.27403  ? 39  GLN A CA  1 
ATOM   52   C C   . GLN A 1 40  ? 144.08975 12.30913  4.65681   1.000 49.76405  ? 39  GLN A C   1 
ATOM   53   O O   . GLN A 1 40  ? 144.55468 11.16626  4.59910   1.000 49.31169  ? 39  GLN A O   1 
ATOM   54   C CB  . GLN A 1 40  ? 146.00986 13.71360  5.49070   1.000 49.79406  ? 39  GLN A CB  1 
ATOM   55   C CG  . GLN A 1 40  ? 146.21458 14.58244  4.26482   1.000 57.32771  ? 39  GLN A CG  1 
ATOM   56   N N   . VAL A 1 41  ? 143.15426 12.75719  3.81871   1.000 48.22404  ? 40  VAL A N   1 
ATOM   57   C CA  . VAL A 1 41  ? 142.45938 11.88524  2.87409   1.000 42.88301  ? 40  VAL A CA  1 
ATOM   58   C C   . VAL A 1 41  ? 143.12435 11.98958  1.51004   1.000 45.13523  ? 40  VAL A C   1 
ATOM   59   O O   . VAL A 1 41  ? 143.37337 13.09530  1.01399   1.000 41.77174  ? 40  VAL A O   1 
ATOM   60   C CB  . VAL A 1 41  ? 140.96546 12.24224  2.78351   1.000 44.61818  ? 40  VAL A CB  1 
ATOM   61   C CG1 . VAL A 1 41  ? 140.25630 11.31964  1.79869   1.000 42.97765  ? 40  VAL A CG1 1 
ATOM   62   C CG2 . VAL A 1 41  ? 140.31734 12.16739  4.15965   1.000 44.08069  ? 40  VAL A CG2 1 
ATOM   63   N N   . GLY A 1 42  ? 143.39910 10.83828  0.89878   1.000 40.49971  ? 41  GLY A N   1 
ATOM   64   C CA  . GLY A 1 42  ? 143.98926 10.78056  -0.41554  1.000 42.50141  ? 41  GLY A CA  1 
ATOM   65   C C   . GLY A 1 42  ? 142.99669 10.33224  -1.46971  1.000 41.07963  ? 41  GLY A C   1 
ATOM   66   O O   . GLY A 1 42  ? 141.78952 10.56819  -1.36069  1.000 40.38588  ? 41  GLY A O   1 
ATOM   67   N N   . PRO A 1 43  ? 143.49020 9.67960   -2.51913  1.000 42.87894  ? 42  PRO A N   1 
ATOM   68   C CA  . PRO A 1 43  ? 142.61623 9.32554   -3.64153  1.000 40.31177  ? 42  PRO A CA  1 
ATOM   69   C C   . PRO A 1 43  ? 141.63188 8.22058   -3.29959  1.000 36.90759  ? 42  PRO A C   1 
ATOM   70   O O   . PRO A 1 43  ? 141.87166 7.37212   -2.43405  1.000 36.08097  ? 42  PRO A O   1 
ATOM   71   C CB  . PRO A 1 43  ? 143.59929 8.85839   -4.72068  1.000 41.64630  ? 42  PRO A CB  1 
ATOM   72   C CG  . PRO A 1 43  ? 144.78986 8.38987   -3.94994  1.000 50.12186  ? 42  PRO A CG  1 
ATOM   73   C CD  . PRO A 1 43  ? 144.89709 9.33888   -2.79187  1.000 45.26069  ? 42  PRO A CD  1 
ATOM   74   N N   . LEU A 1 44  ? 140.51422 8.23509   -4.02069  1.000 32.47505  ? 43  LEU A N   1 
ATOM   75   C CA  . LEU A 1 44  ? 139.55388 7.14626   -3.95443  1.000 32.00856  ? 43  LEU A CA  1 
ATOM   76   C C   . LEU A 1 44  ? 140.20299 5.85030   -4.42536  1.000 38.03065  ? 43  LEU A C   1 
ATOM   77   O O   . LEU A 1 44  ? 140.82698 5.80746   -5.48957  1.000 38.54334  ? 43  LEU A O   1 
ATOM   78   C CB  . LEU A 1 44  ? 138.34231 7.47921   -4.82272  1.000 35.34978  ? 43  LEU A CB  1 
ATOM   79   C CG  . LEU A 1 44  ? 137.17529 6.49502   -4.80573  1.000 34.52079  ? 43  LEU A CG  1 
ATOM   80   C CD1 . LEU A 1 44  ? 136.42902 6.58242   -3.49183  1.000 33.76586  ? 43  LEU A CD1 1 
ATOM   81   C CD2 . LEU A 1 44  ? 136.23934 6.75406   -5.98827  1.000 36.82949  ? 43  LEU A CD2 1 
ATOM   82   N N   . LEU A 1 45  ? 140.06315 4.79364   -3.62737  1.000 33.74191  ? 44  LEU A N   1 
ATOM   83   C CA  . LEU A 1 45  ? 140.59275 3.48913   -4.00610  1.000 32.38522  ? 44  LEU A CA  1 
ATOM   84   C C   . LEU A 1 45  ? 139.55702 2.63473   -4.71343  1.000 34.20805  ? 44  LEU A C   1 
ATOM   85   O O   . LEU A 1 45  ? 139.90768 1.84474   -5.59730  1.000 35.67065  ? 44  LEU A O   1 
ATOM   86   C CB  . LEU A 1 45  ? 141.12194 2.74560   -2.77315  1.000 33.77000  ? 44  LEU A CB  1 
ATOM   87   C CG  . LEU A 1 45  ? 142.33787 3.35897   -2.07060  1.000 35.42025  ? 44  LEU A CG  1 
ATOM   88   C CD1 . LEU A 1 45  ? 142.68783 2.54834   -0.84010  1.000 35.10399  ? 44  LEU A CD1 1 
ATOM   89   C CD2 . LEU A 1 45  ? 143.52207 3.40719   -3.00444  1.000 36.34725  ? 44  LEU A CD2 1 
ATOM   90   N N   . GLY A 1 46  ? 138.29314 2.77754   -4.35249  1.000 35.61119  ? 45  GLY A N   1 
ATOM   91   C CA  . GLY A 1 46  ? 137.23868 2.03784   -5.01893  1.000 33.36084  ? 45  GLY A CA  1 
ATOM   92   C C   . GLY A 1 46  ? 135.91124 2.39153   -4.39459  1.000 33.10508  ? 45  GLY A C   1 
ATOM   93   O O   . GLY A 1 46  ? 135.84224 2.99464   -3.31477  1.000 28.78094  ? 45  GLY A O   1 
ATOM   94   N N   . SER A 1 47  ? 134.84854 2.01566   -5.09954  1.000 28.72367  ? 46  SER A N   1 
ATOM   95   C CA  . SER A 1 47  ? 133.50658 2.17259   -4.56691  1.000 32.13371  ? 46  SER A CA  1 
ATOM   96   C C   . SER A 1 47  ? 132.61364 1.10510   -5.16923  1.000 34.37653  ? 46  SER A C   1 
ATOM   97   O O   . SER A 1 47  ? 132.84524 0.63554   -6.28635  1.000 34.10859  ? 46  SER A O   1 
ATOM   98   C CB  . SER A 1 47  ? 132.91555 3.56046   -4.85754  1.000 35.26945  ? 46  SER A CB  1 
ATOM   99   O OG  . SER A 1 47  ? 132.57565 3.68182   -6.22594  1.000 36.99808  ? 46  SER A OG  1 
ATOM   100  N N   . GLY A 1 48  ? 131.58173 0.74621   -4.42029  1.000 33.01350  ? 47  GLY A N   1 
ATOM   101  C CA  . GLY A 1 48  ? 130.63021 -0.25727  -4.87151  1.000 37.04555  ? 47  GLY A CA  1 
ATOM   102  C C   . GLY A 1 48  ? 129.64966 -0.56088  -3.76377  1.000 41.78615  ? 47  GLY A C   1 
ATOM   103  O O   . GLY A 1 48  ? 129.34902 0.30311   -2.92653  1.000 36.61471  ? 47  GLY A O   1 
ATOM   104  N N   . GLY A 1 49  ? 129.17213 -1.80937  -3.74718  1.000 38.44106  ? 48  GLY A N   1 
ATOM   105  C CA  . GLY A 1 49  ? 128.26168 -2.22355  -2.68968  1.000 36.96360  ? 48  GLY A CA  1 
ATOM   106  C C   . GLY A 1 49  ? 128.84402 -2.07742  -1.30012  1.000 37.95160  ? 48  GLY A C   1 
ATOM   107  O O   . GLY A 1 49  ? 128.09289 -2.00852  -0.32147  1.000 41.12449  ? 48  GLY A O   1 
ATOM   108  N N   . PHE A 1 50  ? 130.16917 -2.02366  -1.19192  1.000 32.12487  ? 49  PHE A N   1 
ATOM   109  C CA  . PHE A 1 50  ? 130.86460 -1.89349  0.07968   1.000 35.40964  ? 49  PHE A CA  1 
ATOM   110  C C   . PHE A 1 50  ? 130.97976 -0.44896  0.55528   1.000 40.66770  ? 49  PHE A C   1 
ATOM   111  O O   . PHE A 1 50  ? 131.55742 -0.21655  1.61999   1.000 37.75202  ? 49  PHE A O   1 
ATOM   112  C CB  . PHE A 1 50  ? 132.26319 -2.49883  -0.04709  1.000 34.68742  ? 49  PHE A CB  1 
ATOM   113  C CG  . PHE A 1 50  ? 133.00814 -2.02008  -1.26353  1.000 36.58552  ? 49  PHE A CG  1 
ATOM   114  C CD1 . PHE A 1 50  ? 133.69045 -0.81249  -1.24556  1.000 34.64515  ? 49  PHE A CD1 1 
ATOM   115  C CD2 . PHE A 1 50  ? 132.99571 -2.76210  -2.43782  1.000 35.27004  ? 49  PHE A CD2 1 
ATOM   116  C CE1 . PHE A 1 50  ? 134.35959 -0.36057  -2.37622  1.000 35.46235  ? 49  PHE A CE1 1 
ATOM   117  C CE2 . PHE A 1 50  ? 133.66859 -2.32060  -3.57059  1.000 39.34540  ? 49  PHE A CE2 1 
ATOM   118  C CZ  . PHE A 1 50  ? 134.35194 -1.11853  -3.53799  1.000 39.28606  ? 49  PHE A CZ  1 
ATOM   119  N N   . GLY A 1 51  ? 130.47490 0.52084   -0.20745  1.000 32.09588  ? 50  GLY A N   1 
ATOM   120  C CA  . GLY A 1 51  ? 130.64372 1.92413   0.13728   1.000 32.44256  ? 50  GLY A CA  1 
ATOM   121  C C   . GLY A 1 51  ? 131.69545 2.59432   -0.72767  1.000 34.56629  ? 50  GLY A C   1 
ATOM   122  O O   . GLY A 1 51  ? 131.93021 2.15928   -1.85871  1.000 32.90793  ? 50  GLY A O   1 
ATOM   123  N N   . SER A 1 52  ? 132.34579 3.64115   -0.21862  1.000 27.91097  ? 51  SER A N   1 
ATOM   124  C CA  . SER A 1 52  ? 133.43725 4.30051   -0.92720  1.000 29.24748  ? 51  SER A CA  1 
ATOM   125  C C   . SER A 1 52  ? 134.67440 4.27518   -0.04574  1.000 29.92219  ? 51  SER A C   1 
ATOM   126  O O   . SER A 1 52  ? 134.59953 4.60889   1.14109   1.000 28.83368  ? 51  SER A O   1 
ATOM   127  C CB  . SER A 1 52  ? 133.07071 5.74641   -1.29651  1.000 29.61190  ? 51  SER A CB  1 
ATOM   128  O OG  . SER A 1 52  ? 131.96060 5.78412   -2.18542  1.000 30.72659  ? 51  SER A OG  1 
ATOM   129  N N   . VAL A 1 53  ? 135.81179 3.88960   -0.61821  1.000 26.28144  ? 52  VAL A N   1 
ATOM   130  C CA  . VAL A 1 53  ? 137.03383 3.67999   0.15193   1.000 26.37563  ? 52  VAL A CA  1 
ATOM   131  C C   . VAL A 1 53  ? 138.12330 4.58953   -0.39284  1.000 26.36560  ? 52  VAL A C   1 
ATOM   132  O O   . VAL A 1 53  ? 138.40090 4.58015   -1.59861  1.000 29.89767  ? 52  VAL A O   1 
ATOM   133  C CB  . VAL A 1 53  ? 137.48634 2.21039   0.11244   1.000 29.76496  ? 52  VAL A CB  1 
ATOM   134  C CG1 . VAL A 1 53  ? 138.76227 2.03524   0.93474   1.000 27.07260  ? 52  VAL A CG1 1 
ATOM   135  C CG2 . VAL A 1 53  ? 136.38493 1.31136   0.63623   1.000 28.45813  ? 52  VAL A CG2 1 
ATOM   136  N N   . TYR A 1 54  ? 138.73814 5.36584   0.49889   1.000 25.51187  ? 53  TYR A N   1 
ATOM   137  C CA  . TYR A 1 54  ? 139.79871 6.30150   0.15991   1.000 30.13060  ? 53  TYR A CA  1 
ATOM   138  C C   . TYR A 1 54  ? 141.09861 5.86798   0.81311   1.000 33.56097  ? 53  TYR A C   1 
ATOM   139  O O   . TYR A 1 54  ? 141.10795 5.29777   1.90997   1.000 32.42637  ? 53  TYR A O   1 
ATOM   140  C CB  . TYR A 1 54  ? 139.48441 7.72882   0.63001   1.000 31.01248  ? 53  TYR A CB  1 
ATOM   141  C CG  . TYR A 1 54  ? 138.27949 8.35301   -0.01119  1.000 32.78913  ? 53  TYR A CG  1 
ATOM   142  C CD1 . TYR A 1 54  ? 137.00203 8.08148   0.46347   1.000 29.75455  ? 53  TYR A CD1 1 
ATOM   143  C CD2 . TYR A 1 54  ? 138.41518 9.21577   -1.09005  1.000 31.49744  ? 53  TYR A CD2 1 
ATOM   144  C CE1 . TYR A 1 54  ? 135.89342 8.64947   -0.11723  1.000 28.11557  ? 53  TYR A CE1 1 
ATOM   145  C CE2 . TYR A 1 54  ? 137.30878 9.79604   -1.67984  1.000 36.07872  ? 53  TYR A CE2 1 
ATOM   146  C CZ  . TYR A 1 54  ? 136.04832 9.50461   -1.19054  1.000 33.51199  ? 53  TYR A CZ  1 
ATOM   147  O OH  . TYR A 1 54  ? 134.93690 10.06348  -1.76518  1.000 30.12530  ? 53  TYR A OH  1 
ATOM   148  N N   . SER A 1 55  ? 142.19725 6.16659   0.13511   1.000 34.54458  ? 54  SER A N   1 
ATOM   149  C CA  . SER A 1 55  ? 143.49806 6.09673   0.77119   1.000 31.76920  ? 54  SER A CA  1 
ATOM   150  C C   . SER A 1 55  ? 143.63053 7.23648   1.76930   1.000 37.06393  ? 54  SER A C   1 
ATOM   151  O O   . SER A 1 55  ? 143.07651 8.32449   1.58290   1.000 39.59855  ? 54  SER A O   1 
ATOM   152  C CB  . SER A 1 55  ? 144.61186 6.17783   -0.27598  1.000 38.34866  ? 54  SER A CB  1 
ATOM   153  O OG  . SER A 1 55  ? 145.87700 6.02339   0.33184   1.000 43.49834  ? 54  SER A OG  1 
ATOM   154  N N   . GLY A 1 56  ? 144.36215 6.97852   2.84913   1.000 35.83223  ? 55  GLY A N   1 
ATOM   155  C CA  . GLY A 1 56  ? 144.50160 7.97324   3.89067   1.000 39.95007  ? 55  GLY A CA  1 
ATOM   156  C C   . GLY A 1 56  ? 145.78617 7.78212   4.66496   1.000 39.44018  ? 55  GLY A C   1 
ATOM   157  O O   . GLY A 1 56  ? 146.50281 6.79035   4.50401   1.000 39.40080  ? 55  GLY A O   1 
ATOM   158  N N   . ILE A 1 57  ? 146.06950 8.76690   5.50982   1.000 38.09106  ? 56  ILE A N   1 
ATOM   159  C CA  . ILE A 1 57  ? 147.22227 8.73886   6.40012   1.000 42.80518  ? 56  ILE A CA  1 
ATOM   160  C C   . ILE A 1 57  ? 146.79656 9.32877   7.73696   1.000 43.76259  ? 56  ILE A C   1 
ATOM   161  O O   . ILE A 1 57  ? 146.22915 10.42442  7.78367   1.000 52.50181  ? 56  ILE A O   1 
ATOM   162  C CB  . ILE A 1 57  ? 148.41561 9.51003   5.80311   1.000 45.61690  ? 56  ILE A CB  1 
ATOM   163  C CG1 . ILE A 1 57  ? 149.17012 8.62562   4.80701   1.000 44.22148  ? 56  ILE A CG1 1 
ATOM   164  C CG2 . ILE A 1 57  ? 149.32902 10.03017  6.90036   1.000 51.16030  ? 56  ILE A CG2 1 
ATOM   165  N N   . ARG A 1 58  ? 147.03616 8.58957   8.81834   1.000 44.00231  ? 57  ARG A N   1 
ATOM   166  C CA  . ARG A 1 58  ? 146.75584 9.09968   10.15309  1.000 44.66599  ? 57  ARG A CA  1 
ATOM   167  C C   . ARG A 1 58  ? 147.78989 10.15822  10.51436  1.000 50.38370  ? 57  ARG A C   1 
ATOM   168  O O   . ARG A 1 58  ? 148.98719 9.86552   10.56922  1.000 54.56177  ? 57  ARG A O   1 
ATOM   169  C CB  . ARG A 1 58  ? 146.77047 7.96158   11.16741  1.000 43.91901  ? 57  ARG A CB  1 
ATOM   170  C CG  . ARG A 1 58  ? 146.43168 8.40502   12.57939  1.000 48.96101  ? 57  ARG A CG  1 
ATOM   171  C CD  . ARG A 1 58  ? 146.12274 7.21309   13.46371  1.000 49.48613  ? 57  ARG A CD  1 
ATOM   172  N NE  . ARG A 1 58  ? 147.27146 6.33293   13.63792  1.000 52.61446  ? 57  ARG A NE  1 
ATOM   173  C CZ  . ARG A 1 58  ? 147.21653 5.15527   14.24397  1.000 51.66608  ? 57  ARG A CZ  1 
ATOM   174  N NH1 . ARG A 1 58  ? 146.08377 4.68908   14.74116  1.000 45.62323  ? 57  ARG A NH1 1 
ATOM   175  N NH2 . ARG A 1 58  ? 148.32298 4.42393   14.34627  1.000 55.05050  ? 57  ARG A NH2 1 
ATOM   176  N N   . VAL A 1 59  ? 147.33415 11.39080  10.75339  1.000 48.61998  ? 58  VAL A N   1 
ATOM   177  C CA  . VAL A 1 59  ? 148.27343 12.48615  10.97447  1.000 55.73557  ? 58  VAL A CA  1 
ATOM   178  C C   . VAL A 1 59  ? 149.05705 12.31296  12.27072  1.000 59.29833  ? 58  VAL A C   1 
ATOM   179  O O   . VAL A 1 59  ? 150.14694 12.87848  12.40417  1.000 67.50628  ? 58  VAL A O   1 
ATOM   180  C CB  . VAL A 1 59  ? 147.54952 13.84728  10.95466  1.000 56.60195  ? 58  VAL A CB  1 
ATOM   181  C CG1 . VAL A 1 59  ? 146.70848 13.98575  9.69235   1.000 56.69063  ? 58  VAL A CG1 1 
ATOM   182  C CG2 . VAL A 1 59  ? 146.69799 14.03387  12.20229  1.000 62.12511  ? 58  VAL A CG2 1 
ATOM   183  N N   . SER A 1 60  ? 148.54090 11.52848  13.22139  1.000 61.21972  ? 59  SER A N   1 
ATOM   184  C CA  . SER A 1 60  ? 149.24433 11.31439  14.48375  1.000 62.54111  ? 59  SER A CA  1 
ATOM   185  C C   . SER A 1 60  ? 150.64343 10.75188  14.25061  1.000 63.64851  ? 59  SER A C   1 
ATOM   186  O O   . SER A 1 60  ? 151.62734 11.25435  14.80646  1.000 68.95992  ? 59  SER A O   1 
ATOM   187  C CB  . SER A 1 60  ? 148.42764 10.38114  15.38180  1.000 56.93197  ? 59  SER A CB  1 
ATOM   188  N N   . ASP A 1 61  ? 150.75491 9.71726   13.40842  1.000 59.34981  ? 60  ASP A N   1 
ATOM   189  C CA  . ASP A 1 61  ? 152.02701 9.03422   13.19827  1.000 56.60584  ? 60  ASP A CA  1 
ATOM   190  C C   . ASP A 1 61  ? 152.29155 8.69981   11.72992  1.000 59.73580  ? 60  ASP A C   1 
ATOM   191  O O   . ASP A 1 61  ? 153.11541 7.81925   11.44601  1.000 59.13218  ? 60  ASP A O   1 
ATOM   192  C CB  . ASP A 1 61  ? 152.08179 7.74496   14.02516  1.000 59.88242  ? 60  ASP A CB  1 
ATOM   193  C CG  . ASP A 1 61  ? 150.89029 6.84106   13.77085  1.000 58.12238  ? 60  ASP A CG  1 
ATOM   194  O OD1 . ASP A 1 61  ? 150.00652 7.23368   12.98157  1.000 62.58477  ? 60  ASP A OD1 1 
ATOM   195  O OD2 . ASP A 1 61  ? 150.83066 5.74166   14.35743  1.000 62.25825  ? 60  ASP A OD2 1 
ATOM   196  N N   . ASN A 1 62  ? 151.61304 9.36960   10.79447  1.000 56.67343  ? 61  ASN A N   1 
ATOM   197  C CA  . ASN A 1 62  ? 151.73622 9.09786   9.35864   1.000 55.62017  ? 61  ASN A CA  1 
ATOM   198  C C   . ASN A 1 62  ? 151.46461 7.63077   9.01612   1.000 53.07539  ? 61  ASN A C   1 
ATOM   199  O O   . ASN A 1 62  ? 151.99057 7.10655   8.03317   1.000 56.41761  ? 61  ASN A O   1 
ATOM   200  C CB  . ASN A 1 62  ? 153.10504 9.53203   8.82354   1.000 56.44834  ? 61  ASN A CB  1 
ATOM   201  C CG  . ASN A 1 62  ? 153.23709 11.04104  8.72110   1.000 53.80373  ? 61  ASN A CG  1 
ATOM   202  N N   . LEU A 1 63  ? 150.63381 6.95302   9.80308   1.000 52.79013  ? 62  LEU A N   1 
ATOM   203  C CA  . LEU A 1 63  ? 150.32326 5.55518   9.51321   1.000 49.43868  ? 62  LEU A CA  1 
ATOM   204  C C   . LEU A 1 63  ? 149.39441 5.46521   8.30631   1.000 45.43941  ? 62  LEU A C   1 
ATOM   205  O O   . LEU A 1 63  ? 148.37716 6.16741   8.26020   1.000 46.11244  ? 62  LEU A O   1 
ATOM   206  C CB  . LEU A 1 63  ? 149.67545 4.87944   10.71699  1.000 44.83014  ? 62  LEU A CB  1 
ATOM   207  C CG  . LEU A 1 63  ? 149.31007 3.41320   10.47446  1.000 45.53049  ? 62  LEU A CG  1 
ATOM   208  C CD1 . LEU A 1 63  ? 150.51479 2.51285   10.70010  1.000 45.36626  ? 62  LEU A CD1 1 
ATOM   209  C CD2 . LEU A 1 63  ? 148.12683 2.97701   11.32969  1.000 46.85884  ? 62  LEU A CD2 1 
ATOM   210  N N   . PRO A 1 64  ? 149.70518 4.62817   7.31726   1.000 43.74366  ? 63  PRO A N   1 
ATOM   211  C CA  . PRO A 1 64  ? 148.79244 4.46011   6.17569   1.000 43.52155  ? 63  PRO A CA  1 
ATOM   212  C C   . PRO A 1 64  ? 147.49980 3.78552   6.61092   1.000 40.11547  ? 63  PRO A C   1 
ATOM   213  O O   . PRO A 1 64  ? 147.51855 2.76643   7.30749   1.000 39.90063  ? 63  PRO A O   1 
ATOM   214  C CB  . PRO A 1 64  ? 149.58444 3.57051   5.20997   1.000 43.78347  ? 63  PRO A CB  1 
ATOM   215  C CG  . PRO A 1 64  ? 150.99106 3.55330   5.73625   1.000 49.02600  ? 63  PRO A CG  1 
ATOM   216  C CD  . PRO A 1 64  ? 150.89787 3.77635   7.20129   1.000 46.63772  ? 63  PRO A CD  1 
ATOM   217  N N   . VAL A 1 65  ? 146.37043 4.35611   6.18925   1.000 36.36956  ? 64  VAL A N   1 
ATOM   218  C CA  . VAL A 1 65  ? 145.06054 3.79227   6.48950   1.000 34.96267  ? 64  VAL A CA  1 
ATOM   219  C C   . VAL A 1 65  ? 144.20302 3.80124   5.22947   1.000 35.52255  ? 64  VAL A C   1 
ATOM   220  O O   . VAL A 1 65  ? 144.50505 4.47526   4.24160   1.000 35.97737  ? 64  VAL A O   1 
ATOM   221  C CB  . VAL A 1 65  ? 144.33834 4.55161   7.63535   1.000 37.92164  ? 64  VAL A CB  1 
ATOM   222  C CG1 . VAL A 1 65  ? 145.10361 4.41043   8.95192   1.000 36.46823  ? 64  VAL A CG1 1 
ATOM   223  C CG2 . VAL A 1 65  ? 144.13710 6.02586   7.28580   1.000 36.49538  ? 64  VAL A CG2 1 
ATOM   224  N N   . ALA A 1 66  ? 143.12502 3.02819   5.27565   1.000 29.58598  ? 65  ALA A N   1 
ATOM   225  C CA  . ALA A 1 66  ? 142.04911 3.10506   4.29874   1.000 29.63653  ? 65  ALA A CA  1 
ATOM   226  C C   . ALA A 1 66  ? 140.80497 3.62273   5.00606   1.000 30.55358  ? 65  ALA A C   1 
ATOM   227  O O   . ALA A 1 66  ? 140.53599 3.25023   6.15038   1.000 30.92297  ? 65  ALA A O   1 
ATOM   228  C CB  . ALA A 1 66  ? 141.77538 1.74422   3.65149   1.000 28.72875  ? 65  ALA A CB  1 
ATOM   229  N N   . ILE A 1 67  ? 140.06483 4.50398   4.33868   1.000 28.34700  ? 66  ILE A N   1 
ATOM   230  C CA  . ILE A 1 67  ? 138.95522 5.22916   4.95376   1.000 29.65142  ? 66  ILE A CA  1 
ATOM   231  C C   . ILE A 1 67  ? 137.68703 4.85196   4.20154   1.000 31.06144  ? 66  ILE A C   1 
ATOM   232  O O   . ILE A 1 67  ? 137.48013 5.28344   3.05552   1.000 28.31561  ? 66  ILE A O   1 
ATOM   233  C CB  . ILE A 1 67  ? 139.18733 6.74590   4.93963   1.000 31.19327  ? 66  ILE A CB  1 
ATOM   234  C CG1 . ILE A 1 67  ? 140.52883 7.08858   5.59969   1.000 29.74075  ? 66  ILE A CG1 1 
ATOM   235  C CG2 . ILE A 1 67  ? 138.06504 7.44902   5.66850   1.000 28.30711  ? 66  ILE A CG2 1 
ATOM   236  C CD1 . ILE A 1 67  ? 140.84684 8.59119   5.61451   1.000 35.01369  ? 66  ILE A CD1 1 
ATOM   237  N N   . LYS A 1 68  ? 136.84948 4.02917   4.83107   1.000 26.89903  ? 67  LYS A N   1 
ATOM   238  C CA  . LYS A 1 68  ? 135.66015 3.48182   4.19536   1.000 24.55211  ? 67  LYS A CA  1 
ATOM   239  C C   . LYS A 1 68  ? 134.41312 4.19463   4.70333   1.000 31.49756  ? 67  LYS A C   1 
ATOM   240  O O   . LYS A 1 68  ? 134.17347 4.25728   5.91776   1.000 28.94902  ? 67  LYS A O   1 
ATOM   241  C CB  . LYS A 1 68  ? 135.53027 1.97823   4.45703   1.000 23.92931  ? 67  LYS A CB  1 
ATOM   242  C CG  . LYS A 1 68  ? 134.22934 1.40755   3.90493   1.000 28.00214  ? 67  LYS A CG  1 
ATOM   243  C CD  . LYS A 1 68  ? 133.99269 -0.04474  4.32611   1.000 36.56085  ? 67  LYS A CD  1 
ATOM   244  C CE  . LYS A 1 68  ? 134.72378 -1.00591  3.42881   1.000 35.88446  ? 67  LYS A CE  1 
ATOM   245  N NZ  . LYS A 1 68  ? 134.18779 -2.39782  3.57335   1.000 40.73646  ? 67  LYS A NZ  1 
ATOM   246  N N   . HIS A 1 69  ? 133.61896 4.70970   3.76898   1.000 27.97956  ? 68  HIS A N   1 
ATOM   247  C CA  . HIS A 1 69  ? 132.36771 5.39815   4.05388   1.000 28.97573  ? 68  HIS A CA  1 
ATOM   248  C C   . HIS A 1 69  ? 131.21284 4.50302   3.63629   1.000 31.28303  ? 68  HIS A C   1 
ATOM   249  O O   . HIS A 1 69  ? 131.18095 4.01596   2.49922   1.000 28.37679  ? 68  HIS A O   1 
ATOM   250  C CB  . HIS A 1 69  ? 132.27275 6.72250   3.28884   1.000 30.46521  ? 68  HIS A CB  1 
ATOM   251  C CG  . HIS A 1 69  ? 133.36120 7.69095   3.61702   1.000 31.91045  ? 68  HIS A CG  1 
ATOM   252  N ND1 . HIS A 1 69  ? 133.15142 8.80684   4.39675   1.000 28.26943  ? 68  HIS A ND1 1 
ATOM   253  C CD2 . HIS A 1 69  ? 134.67095 7.71337   3.26843   1.000 31.72872  ? 68  HIS A CD2 1 
ATOM   254  C CE1 . HIS A 1 69  ? 134.28722 9.46855   4.52636   1.000 31.30552  ? 68  HIS A CE1 1 
ATOM   255  N NE2 . HIS A 1 69  ? 135.22384 8.82864   3.84672   1.000 31.17948  ? 68  HIS A NE2 1 
ATOM   256  N N   . VAL A 1 70  ? 130.25818 4.30040   4.53850   1.000 27.38368  ? 69  VAL A N   1 
ATOM   257  C CA  . VAL A 1 70  ? 129.06653 3.51427   4.24157   1.000 30.66817  ? 69  VAL A CA  1 
ATOM   258  C C   . VAL A 1 70  ? 127.84906 4.37967   4.52823   1.000 39.43087  ? 69  VAL A C   1 
ATOM   259  O O   . VAL A 1 70  ? 127.74451 4.96707   5.60919   1.000 32.64952  ? 69  VAL A O   1 
ATOM   260  C CB  . VAL A 1 70  ? 129.03200 2.20403   5.05108   1.000 33.24677  ? 69  VAL A CB  1 
ATOM   261  C CG1 . VAL A 1 70  ? 130.17126 1.30345   4.61109   1.000 40.11618  ? 69  VAL A CG1 1 
ATOM   262  C CG2 . VAL A 1 70  ? 129.15623 2.47974   6.53349   1.000 43.15262  ? 69  VAL A CG2 1 
ATOM   263  N N   . GLU A 1 71  ? 126.94695 4.48127   3.55590   1.000 35.12816  ? 70  GLU A N   1 
ATOM   264  C CA  . GLU A 1 71  ? 125.73774 5.27043   3.75955   1.000 38.65471  ? 70  GLU A CA  1 
ATOM   265  C C   . GLU A 1 71  ? 124.76744 4.51934   4.66244   1.000 36.85489  ? 70  GLU A C   1 
ATOM   266  O O   . GLU A 1 71  ? 124.55037 3.31525   4.50112   1.000 38.60173  ? 70  GLU A O   1 
ATOM   267  C CB  . GLU A 1 71  ? 125.07202 5.59632   2.42009   1.000 40.94872  ? 70  GLU A CB  1 
ATOM   268  C CG  . GLU A 1 71  ? 125.59200 6.86908   1.76512   1.000 47.22114  ? 70  GLU A CG  1 
ATOM   269  N N   . LYS A 1 72  ? 124.18688 5.23991   5.62739   1.000 40.76496  ? 71  LYS A N   1 
ATOM   270  C CA  . LYS A 1 72  ? 123.27141 4.60601   6.57267   1.000 40.41596  ? 71  LYS A CA  1 
ATOM   271  C C   . LYS A 1 72  ? 122.08299 3.97176   5.86153   1.000 41.85647  ? 71  LYS A C   1 
ATOM   272  O O   . LYS A 1 72  ? 121.64819 2.87472   6.22936   1.000 46.92384  ? 71  LYS A O   1 
ATOM   273  C CB  . LYS A 1 72  ? 122.79776 5.62004   7.61327   1.000 39.05705  ? 71  LYS A CB  1 
ATOM   274  C CG  . LYS A 1 72  ? 123.84569 5.97688   8.65352   1.000 35.60108  ? 71  LYS A CG  1 
ATOM   275  C CD  . LYS A 1 72  ? 123.25717 6.90765   9.70157   1.000 40.62127  ? 71  LYS A CD  1 
ATOM   276  C CE  . LYS A 1 72  ? 124.28611 7.30298   10.73733  1.000 39.08486  ? 71  LYS A CE  1 
ATOM   277  N NZ  . LYS A 1 72  ? 123.71528 8.27052   11.72745  1.000 43.11055  ? 71  LYS A NZ  1 
ATOM   278  N N   . ASP A 1 73  ? 121.55981 4.63157   4.82338   1.000 50.25726  ? 72  ASP A N   1 
ATOM   279  C CA  . ASP A 1 73  ? 120.41168 4.09598   4.09648   1.000 46.09441  ? 72  ASP A CA  1 
ATOM   280  C C   . ASP A 1 73  ? 120.71225 2.76064   3.42527   1.000 54.21785  ? 72  ASP A C   1 
ATOM   281  O O   . ASP A 1 73  ? 119.77808 2.01684   3.10708   1.000 55.24413  ? 72  ASP A O   1 
ATOM   282  C CB  . ASP A 1 73  ? 119.93426 5.10106   3.04416   1.000 56.89642  ? 72  ASP A CB  1 
ATOM   283  C CG  . ASP A 1 73  ? 119.54526 6.43938   3.64678   1.000 65.16715  ? 72  ASP A CG  1 
ATOM   284  O OD1 . ASP A 1 73  ? 119.28105 6.49269   4.86713   1.000 68.52702  ? 72  ASP A OD1 1 
ATOM   285  O OD2 . ASP A 1 73  ? 119.49662 7.43972   2.89858   1.000 79.80558  ? 72  ASP A OD2 1 
ATOM   286  N N   . ARG A 1 74  ? 121.98408 2.43653   3.20363   1.000 46.81333  ? 73  ARG A N   1 
ATOM   287  C CA  . ARG A 1 74  ? 122.36257 1.22249   2.49628   1.000 45.97532  ? 73  ARG A CA  1 
ATOM   288  C C   . ARG A 1 74  ? 122.71700 0.07343   3.42673   1.000 57.12154  ? 73  ARG A C   1 
ATOM   289  O O   . ARG A 1 74  ? 123.08065 -1.00540  2.94826   1.000 64.54706  ? 73  ARG A O   1 
ATOM   290  C CB  . ARG A 1 74  ? 123.54044 1.50599   1.55827   1.000 44.90558  ? 73  ARG A CB  1 
ATOM   291  C CG  . ARG A 1 74  ? 123.16962 2.29552   0.31732   1.000 49.07760  ? 73  ARG A CG  1 
ATOM   292  N N   . ILE A 1 75  ? 122.61291 0.26626   4.73489   1.000 50.16127  ? 74  ILE A N   1 
ATOM   293  C CA  . ILE A 1 75  ? 123.05038 -0.73421  5.69908   1.000 54.96738  ? 74  ILE A CA  1 
ATOM   294  C C   . ILE A 1 75  ? 121.88732 -1.68209  5.96624   1.000 59.22523  ? 74  ILE A C   1 
ATOM   295  O O   . ILE A 1 75  ? 120.86253 -1.28303  6.52549   1.000 57.88198  ? 74  ILE A O   1 
ATOM   296  C CB  . ILE A 1 75  ? 123.55861 -0.07563  6.98490   1.000 50.62413  ? 74  ILE A CB  1 
ATOM   297  C CG1 . ILE A 1 75  ? 124.86264 0.67286   6.68289   1.000 48.62244  ? 74  ILE A CG1 1 
ATOM   298  C CG2 . ILE A 1 75  ? 123.75277 -1.11590  8.08056   1.000 52.76288  ? 74  ILE A CG2 1 
ATOM   299  C CD1 . ILE A 1 75  ? 125.21392 1.73084   7.69140   1.000 50.73474  ? 74  ILE A CD1 1 
ATOM   300  N N   . SER A 1 76  ? 122.04876 -2.94307  5.55865   1.000 63.57615  ? 75  SER A N   1 
ATOM   301  C CA  . SER A 1 76  ? 121.00679 -3.95215  5.71023   1.000 60.63635  ? 75  SER A CA  1 
ATOM   302  C C   . SER A 1 76  ? 120.87943 -4.41049  7.15703   1.000 62.70737  ? 75  SER A C   1 
ATOM   303  O O   . SER A 1 76  ? 119.83688 -4.20568  7.78455   1.000 62.29935  ? 75  SER A O   1 
ATOM   304  C CB  . SER A 1 76  ? 121.29348 -5.15217  4.80581   1.000 65.18413  ? 75  SER A CB  1 
ATOM   305  N N   . ASP A 1 77  ? 121.92896 -5.03229  7.69319   1.000 57.02412  ? 76  ASP A N   1 
ATOM   306  C CA  . ASP A 1 77  ? 121.90798 -5.59599  9.03625   1.000 55.79089  ? 76  ASP A CA  1 
ATOM   307  C C   . ASP A 1 77  ? 122.59629 -4.65289  10.01496  1.000 49.47014  ? 76  ASP A C   1 
ATOM   308  O O   . ASP A 1 77  ? 123.68870 -4.14205  9.73874   1.000 46.20057  ? 76  ASP A O   1 
ATOM   309  C CB  . ASP A 1 77  ? 122.58469 -6.96954  9.06349   1.000 58.97537  ? 76  ASP A CB  1 
ATOM   310  C CG  . ASP A 1 77  ? 121.92427 -7.96577  8.13066   1.000 61.99909  ? 76  ASP A CG  1 
ATOM   311  N N   . TRP A 1 78  ? 121.95693 -4.43190  11.15514  1.000 49.56571  ? 77  TRP A N   1 
ATOM   312  C CA  . TRP A 1 78  ? 122.50087 -3.61770  12.22731  1.000 50.75947  ? 77  TRP A CA  1 
ATOM   313  C C   . TRP A 1 78  ? 122.84601 -4.49914  13.41634  1.000 52.48589  ? 77  TRP A C   1 
ATOM   314  O O   . TRP A 1 78  ? 122.31368 -5.60030  13.58162  1.000 60.38243  ? 77  TRP A O   1 
ATOM   315  C CB  . TRP A 1 78  ? 121.51250 -2.52556  12.65575  1.000 52.04281  ? 77  TRP A CB  1 
ATOM   316  C CG  . TRP A 1 78  ? 121.29838 -1.47508  11.60814  1.000 54.37552  ? 77  TRP A CG  1 
ATOM   317  C CD1 . TRP A 1 78  ? 120.46913 -1.55256  10.52676  1.000 54.81789  ? 77  TRP A CD1 1 
ATOM   318  C CD2 . TRP A 1 78  ? 121.92783 -0.18894  11.54008  1.000 50.24924  ? 77  TRP A CD2 1 
ATOM   319  N NE1 . TRP A 1 78  ? 120.54451 -0.39510  9.78880   1.000 56.05863  ? 77  TRP A NE1 1 
ATOM   320  C CE2 . TRP A 1 78  ? 121.43030 0.45940   10.39081  1.000 49.66840  ? 77  TRP A CE2 1 
ATOM   321  C CE3 . TRP A 1 78  ? 122.85820 0.47910   12.34188  1.000 51.97537  ? 77  TRP A CE3 1 
ATOM   322  C CZ2 . TRP A 1 78  ? 121.83305 1.74396   10.02237  1.000 52.62470  ? 77  TRP A CZ2 1 
ATOM   323  C CZ3 . TRP A 1 78  ? 123.25819 1.75209   11.97444  1.000 52.17744  ? 77  TRP A CZ3 1 
ATOM   324  C CH2 . TRP A 1 78  ? 122.74596 2.37149   10.82355  1.000 50.38233  ? 77  TRP A CH2 1 
ATOM   325  N N   . GLY A 1 79  ? 123.76058 -4.00026  14.24355  1.000 52.18105  ? 78  GLY A N   1 
ATOM   326  C CA  . GLY A 1 79  ? 124.15689 -4.69036  15.45050  1.000 50.88909  ? 78  GLY A CA  1 
ATOM   327  C C   . GLY A 1 79  ? 124.39015 -3.69856  16.56864  1.000 58.58467  ? 78  GLY A C   1 
ATOM   328  O O   . GLY A 1 79  ? 124.25693 -2.48628  16.38700  1.000 60.14647  ? 78  GLY A O   1 
ATOM   329  N N   . GLU A 1 80  ? 124.73927 -4.23672  17.72956  1.000 56.36391  ? 79  GLU A N   1 
ATOM   330  C CA  . GLU A 1 80  ? 124.96594 -3.43067  18.91687  1.000 70.52748  ? 79  GLU A CA  1 
ATOM   331  C C   . GLU A 1 80  ? 126.32479 -3.77133  19.50204  1.000 76.10437  ? 79  GLU A C   1 
ATOM   332  O O   . GLU A 1 80  ? 126.70847 -4.94369  19.56971  1.000 77.18201  ? 79  GLU A O   1 
ATOM   333  C CB  . GLU A 1 80  ? 123.86751 -3.65314  19.97178  1.000 71.72835  ? 79  GLU A CB  1 
ATOM   334  N N   . LEU A 1 81  ? 127.05303 -2.73808  19.90107  1.000 82.23957  ? 80  LEU A N   1 
ATOM   335  C CA  . LEU A 1 81  ? 128.29462 -2.90363  20.63464  1.000 95.13228  ? 80  LEU A CA  1 
ATOM   336  C C   . LEU A 1 81  ? 127.97758 -3.20617  22.09535  1.000 104.52916 ? 80  LEU A C   1 
ATOM   337  O O   . LEU A 1 81  ? 126.82116 -3.13429  22.52006  1.000 100.60525 ? 80  LEU A O   1 
ATOM   338  C CB  . LEU A 1 81  ? 129.14288 -1.64135  20.48798  1.000 95.58885  ? 80  LEU A CB  1 
ATOM   339  N N   . PRO A 1 82  ? 128.98296 -3.58252  22.89393  1.000 108.58681 ? 81  PRO A N   1 
ATOM   340  C CA  . PRO A 1 82  ? 128.74695 -3.69160  24.34434  1.000 108.49569 ? 81  PRO A CA  1 
ATOM   341  C C   . PRO A 1 82  ? 128.16185 -2.42905  24.95995  1.000 107.73588 ? 81  PRO A C   1 
ATOM   342  O O   . PRO A 1 82  ? 127.30231 -2.51880  25.84480  1.000 106.89967 ? 81  PRO A O   1 
ATOM   343  C CB  . PRO A 1 82  ? 130.14455 -4.01090  24.90305  1.000 111.51107 ? 81  PRO A CB  1 
ATOM   344  C CG  . PRO A 1 82  ? 131.10839 -3.81306  23.75094  1.000 109.89762 ? 81  PRO A CG  1 
ATOM   345  C CD  . PRO A 1 82  ? 130.31270 -4.09447  22.52549  1.000 106.81652 ? 81  PRO A CD  1 
ATOM   346  N N   . ASN A 1 83  ? 128.58837 -1.25009  24.50184  1.000 110.02312 ? 82  ASN A N   1 
ATOM   347  C CA  . ASN A 1 83  ? 128.03866 0.00083   25.01102  1.000 106.79107 ? 82  ASN A CA  1 
ATOM   348  C C   . ASN A 1 83  ? 126.57360 0.19905   24.64221  1.000 107.59046 ? 82  ASN A C   1 
ATOM   349  O O   . ASN A 1 83  ? 125.95936 1.15988   25.11794  1.000 103.41576 ? 82  ASN A O   1 
ATOM   350  C CB  . ASN A 1 83  ? 128.86216 1.18315   24.49332  1.000 96.66174  ? 82  ASN A CB  1 
ATOM   351  N N   . GLY A 1 84  ? 126.00048 -0.67771  23.81957  1.000 105.80076 ? 83  GLY A N   1 
ATOM   352  C CA  . GLY A 1 84  ? 124.64733 -0.50373  23.34228  1.000 100.48073 ? 83  GLY A CA  1 
ATOM   353  C C   . GLY A 1 84  ? 124.51028 0.40105   22.13918  1.000 96.57515  ? 83  GLY A C   1 
ATOM   354  O O   . GLY A 1 84  ? 123.39359 0.55561   21.62608  1.000 96.43956  ? 83  GLY A O   1 
ATOM   355  N N   . THR A 1 85  ? 125.60151 1.00862   21.67697  1.000 89.29394  ? 84  THR A N   1 
ATOM   356  C CA  . THR A 1 85  ? 125.54456 1.84705   20.48846  1.000 82.69232  ? 84  THR A CA  1 
ATOM   357  C C   . THR A 1 85  ? 125.15449 1.01103   19.27525  1.000 75.85560  ? 84  THR A C   1 
ATOM   358  O O   . THR A 1 85  ? 125.71278 -0.06510  19.04119  1.000 72.81448  ? 84  THR A O   1 
ATOM   359  C CB  . THR A 1 85  ? 126.89441 2.52600   20.25487  1.000 69.54426  ? 84  THR A CB  1 
ATOM   360  N N   . ARG A 1 86  ? 124.18035 1.50534   18.51443  1.000 67.20097  ? 85  ARG A N   1 
ATOM   361  C CA  . ARG A 1 86  ? 123.71161 0.82698   17.31225  1.000 65.52035  ? 85  ARG A CA  1 
ATOM   362  C C   . ARG A 1 86  ? 124.66667 1.13045   16.16025  1.000 65.80597  ? 85  ARG A C   1 
ATOM   363  O O   . ARG A 1 86  ? 124.84035 2.29371   15.77810  1.000 58.52186  ? 85  ARG A O   1 
ATOM   364  C CB  . ARG A 1 86  ? 122.28716 1.27595   16.98895  1.000 66.42484  ? 85  ARG A CB  1 
ATOM   365  C CG  . ARG A 1 86  ? 121.59201 0.52521   15.86275  1.000 71.35493  ? 85  ARG A CG  1 
ATOM   366  C CD  . ARG A 1 86  ? 120.10360 0.88944   15.81247  1.000 72.28098  ? 85  ARG A CD  1 
ATOM   367  N NE  . ARG A 1 86  ? 119.39034 0.24613   14.71240  1.000 72.81351  ? 85  ARG A NE  1 
ATOM   368  C CZ  . ARG A 1 86  ? 119.00543 0.86136   13.60049  1.000 71.31938  ? 85  ARG A CZ  1 
ATOM   369  N NH1 . ARG A 1 86  ? 119.24412 2.14843   13.40266  1.000 70.12406  ? 85  ARG A NH1 1 
ATOM   370  N NH2 . ARG A 1 86  ? 118.35944 0.16906   12.66521  1.000 65.32497  ? 85  ARG A NH2 1 
ATOM   371  N N   . VAL A 1 87  ? 125.30074 0.09266   15.62109  1.000 55.00875  ? 86  VAL A N   1 
ATOM   372  C CA  . VAL A 1 87  ? 126.29866 0.26087   14.56655  1.000 50.03880  ? 86  VAL A CA  1 
ATOM   373  C C   . VAL A 1 87  ? 125.99482 -0.73929  13.45740  1.000 47.45643  ? 86  VAL A C   1 
ATOM   374  O O   . VAL A 1 87  ? 125.27852 -1.72862  13.67607  1.000 50.03051  ? 86  VAL A O   1 
ATOM   375  C CB  . VAL A 1 87  ? 127.73827 0.06728   15.10273  1.000 48.80945  ? 86  VAL A CB  1 
ATOM   376  C CG1 . VAL A 1 87  ? 128.05545 1.09496   16.18290  1.000 47.74327  ? 86  VAL A CG1 1 
ATOM   377  C CG2 . VAL A 1 87  ? 127.93656 -1.35657  15.62070  1.000 43.81006  ? 86  VAL A CG2 1 
ATOM   378  N N   . PRO A 1 88  ? 126.51681 -0.50543  12.25343  1.000 43.60413  ? 87  PRO A N   1 
ATOM   379  C CA  . PRO A 1 88  ? 126.40568 -1.52941  11.20878  1.000 41.00831  ? 87  PRO A CA  1 
ATOM   380  C C   . PRO A 1 88  ? 126.99141 -2.84745  11.69186  1.000 36.29095  ? 87  PRO A C   1 
ATOM   381  O O   . PRO A 1 88  ? 127.93804 -2.87764  12.48154  1.000 36.83009  ? 87  PRO A O   1 
ATOM   382  C CB  . PRO A 1 88  ? 127.22248 -0.94648  10.04700  1.000 38.24778  ? 87  PRO A CB  1 
ATOM   383  C CG  . PRO A 1 88  ? 127.25256 0.51994   10.30806  1.000 39.16430  ? 87  PRO A CG  1 
ATOM   384  C CD  . PRO A 1 88  ? 127.23663 0.69020   11.77927  1.000 39.23286  ? 87  PRO A CD  1 
ATOM   385  N N   A MET A 1 89  ? 126.39196 -3.94093  11.21257  0.529 37.64976  ? 88  MET A N   1 
ATOM   386  N N   B MET A 1 89  ? 126.41240 -3.95485  11.22094  0.471 37.64819  ? 88  MET A N   1 
ATOM   387  C CA  A MET A 1 89  ? 126.91161 -5.27594  11.49129  0.529 37.89098  ? 88  MET A CA  1 
ATOM   388  C CA  B MET A 1 89  ? 126.96479 -5.25546  11.59011  0.471 37.83827  ? 88  MET A CA  1 
ATOM   389  C C   A MET A 1 89  ? 128.38363 -5.38533  11.11397  0.529 32.01613  ? 88  MET A C   1 
ATOM   390  C C   B MET A 1 89  ? 128.40491 -5.40544  11.11272  0.471 32.01619  ? 88  MET A C   1 
ATOM   391  O O   A MET A 1 89  ? 129.16320 -6.05617  11.79963  0.529 30.94536  ? 88  MET A O   1 
ATOM   392  O O   B MET A 1 89  ? 129.18721 -6.13230  11.73426  0.471 30.95867  ? 88  MET A O   1 
ATOM   393  C CB  A MET A 1 89  ? 126.08482 -6.31577  10.73052  0.529 38.78384  ? 88  MET A CB  1 
ATOM   394  C CB  B MET A 1 89  ? 126.09871 -6.39204  11.04012  0.471 39.00217  ? 88  MET A CB  1 
ATOM   395  C CG  A MET A 1 89  ? 126.55481 -7.74714  10.90349  0.529 34.58090  ? 88  MET A CG  1 
ATOM   396  C CG  B MET A 1 89  ? 124.96832 -6.83290  11.97131  0.471 40.33532  ? 88  MET A CG  1 
ATOM   397  S SD  A MET A 1 89  ? 126.46554 -8.28779  12.60788  0.529 42.57011  ? 88  MET A SD  1 
ATOM   398  S SD  B MET A 1 89  ? 125.50722 -7.29465  13.63432  0.471 42.53764  ? 88  MET A SD  1 
ATOM   399  C CE  A MET A 1 89  ? 124.70506 -8.14284  12.92155  0.529 43.19756  ? 88  MET A CE  1 
ATOM   400  C CE  B MET A 1 89  ? 126.55900 -8.70222  13.29473  0.471 38.00341  ? 88  MET A CE  1 
ATOM   401  N N   . GLU A 1 90  ? 128.78114 -4.71623  10.02903  1.000 29.69497  ? 89  GLU A N   1 
ATOM   402  C CA  . GLU A 1 90  ? 130.16559 -4.78084  9.57103   1.000 28.05989  ? 89  GLU A CA  1 
ATOM   403  C C   . GLU A 1 90  ? 131.13474 -4.32270  10.66037  1.000 26.45777  ? 89  GLU A C   1 
ATOM   404  O O   . GLU A 1 90  ? 132.22381 -4.89286  10.81623  1.000 26.49081  ? 89  GLU A O   1 
ATOM   405  C CB  . GLU A 1 90  ? 130.33256 -3.93741  8.30200   1.000 30.18944  ? 89  GLU A CB  1 
ATOM   406  C CG  . GLU A 1 90  ? 131.73953 -3.94045  7.75626   1.000 28.90805  ? 89  GLU A CG  1 
ATOM   407  C CD  . GLU A 1 90  ? 131.90778 -3.08543  6.49593   1.000 35.98855  ? 89  GLU A CD  1 
ATOM   408  O OE1 . GLU A 1 90  ? 130.93373 -2.44153  6.05197   1.000 31.74444  ? 89  GLU A OE1 1 
ATOM   409  O OE2 . GLU A 1 90  ? 133.02956 -3.06749  5.96081   1.000 29.37518  ? 89  GLU A OE2 1 
ATOM   410  N N   . VAL A 1 91  ? 130.74865 -3.30710  11.43564  1.000 27.20350  ? 90  VAL A N   1 
ATOM   411  C CA  . VAL A 1 91  ? 131.58839 -2.84503  12.54013  1.000 24.74020  ? 90  VAL A CA  1 
ATOM   412  C C   . VAL A 1 91  ? 131.64498 -3.88640  13.65535  1.000 31.10560  ? 90  VAL A C   1 
ATOM   413  O O   . VAL A 1 91  ? 132.71328 -4.13798  14.22556  1.000 28.20831  ? 90  VAL A O   1 
ATOM   414  C CB  . VAL A 1 91  ? 131.08697 -1.48360  13.05684  1.000 30.34172  ? 90  VAL A CB  1 
ATOM   415  C CG1 . VAL A 1 91  ? 131.82302 -1.08444  14.33081  1.000 33.77603  ? 90  VAL A CG1 1 
ATOM   416  C CG2 . VAL A 1 91  ? 131.27321 -0.41188  11.98385  1.000 30.58704  ? 90  VAL A CG2 1 
ATOM   417  N N   . VAL A 1 92  ? 130.50304 -4.50193  13.99124  1.000 26.67997  ? 91  VAL A N   1 
ATOM   418  C CA  . VAL A 1 92  ? 130.49773 -5.55549  15.00238  1.000 29.46961  ? 91  VAL A CA  1 
ATOM   419  C C   . VAL A 1 92  ? 131.44950 -6.67192  14.60708  1.000 26.47810  ? 91  VAL A C   1 
ATOM   420  O O   . VAL A 1 92  ? 132.26311 -7.13532  15.41709  1.000 27.11911  ? 91  VAL A O   1 
ATOM   421  C CB  . VAL A 1 92  ? 129.07231 -6.09661  15.21741  1.000 30.08325  ? 91  VAL A CB  1 
ATOM   422  C CG1 . VAL A 1 92  ? 129.10501 -7.36907  16.08957  1.000 31.28362  ? 91  VAL A CG1 1 
ATOM   423  C CG2 . VAL A 1 92  ? 128.18681 -5.02931  15.83754  1.000 38.56390  ? 91  VAL A CG2 1 
ATOM   424  N N   . LEU A 1 93  ? 131.34154 -7.13883  13.35931  1.000 23.67232  ? 92  LEU A N   1 
ATOM   425  C CA  . LEU A 1 93  ? 132.15607 -8.26274  12.90130  1.000 22.64956  ? 92  LEU A CA  1 
ATOM   426  C C   . LEU A 1 93  ? 133.63390 -7.89916  12.87880  1.000 24.28952  ? 92  LEU A C   1 
ATOM   427  O O   . LEU A 1 93  ? 134.48439 -8.68787  13.30859  1.000 25.25097  ? 92  LEU A O   1 
ATOM   428  C CB  . LEU A 1 93  ? 131.69797 -8.71269  11.50383  1.000 22.40691  ? 92  LEU A CB  1 
ATOM   429  C CG  . LEU A 1 93  ? 130.22436 -9.13637  11.38248  1.000 25.06276  ? 92  LEU A CG  1 
ATOM   430  C CD1 . LEU A 1 93  ? 129.90949 -9.53224  9.93488   1.000 27.78125  ? 92  LEU A CD1 1 
ATOM   431  C CD2 . LEU A 1 93  ? 129.88189 -10.27555 12.35819  1.000 25.20956  ? 92  LEU A CD2 1 
ATOM   432  N N   . LEU A 1 94  ? 133.96338 -6.71873  12.34202  1.000 23.91405  ? 93  LEU A N   1 
ATOM   433  C CA  . LEU A 1 94  ? 135.36149 -6.30245  12.29257  1.000 24.49987  ? 93  LEU A CA  1 
ATOM   434  C C   . LEU A 1 94  ? 135.95816 -6.21000  13.69328  1.000 25.06469  ? 93  LEU A C   1 
ATOM   435  O O   . LEU A 1 94  ? 137.10569 -6.61102  13.91256  1.000 28.02694  ? 93  LEU A O   1 
ATOM   436  C CB  . LEU A 1 94  ? 135.48976 -4.96214  11.55915  1.000 24.10874  ? 93  LEU A CB  1 
ATOM   437  C CG  . LEU A 1 94  ? 135.46772 -5.04213  10.02207  1.000 25.59158  ? 93  LEU A CG  1 
ATOM   438  C CD1 . LEU A 1 94  ? 135.27408 -3.64536  9.40700   1.000 27.04890  ? 93  LEU A CD1 1 
ATOM   439  C CD2 . LEU A 1 94  ? 136.72644 -5.68167  9.49051   1.000 30.27630  ? 93  LEU A CD2 1 
ATOM   440  N N   . LYS A 1 95  ? 135.19974 -5.67869  14.65166  1.000 26.81235  ? 94  LYS A N   1 
ATOM   441  C CA  . LYS A 1 95  ? 135.71326 -5.60392  16.01863  1.000 25.87143  ? 94  LYS A CA  1 
ATOM   442  C C   . LYS A 1 95  ? 136.00911 -6.99366  16.56301  1.000 26.61179  ? 94  LYS A C   1 
ATOM   443  O O   . LYS A 1 95  ? 137.01145 -7.19852  17.26015  1.000 31.18058  ? 94  LYS A O   1 
ATOM   444  C CB  . LYS A 1 95  ? 134.72260 -4.86994  16.92736  1.000 30.29667  ? 94  LYS A CB  1 
ATOM   445  C CG  . LYS A 1 95  ? 134.76933 -3.34009  16.81024  1.000 32.29073  ? 94  LYS A CG  1 
ATOM   446  C CD  . LYS A 1 95  ? 133.84323 -2.66641  17.82642  1.000 42.92125  ? 94  LYS A CD  1 
ATOM   447  N N   . LYS A 1 96  ? 135.16040 -7.97027  16.23428  1.000 25.18604  ? 95  LYS A N   1 
ATOM   448  C CA  . LYS A 1 96  ? 135.37039 -9.32290  16.73975  1.000 26.94343  ? 95  LYS A CA  1 
ATOM   449  C C   . LYS A 1 96  ? 136.63407 -9.96396  16.17448  1.000 29.52642  ? 95  LYS A C   1 
ATOM   450  O O   . LYS A 1 96  ? 137.24758 -10.79951 16.85115  1.000 29.41947  ? 95  LYS A O   1 
ATOM   451  C CB  . LYS A 1 96  ? 134.14305 -10.18707 16.44477  1.000 29.80063  ? 95  LYS A CB  1 
ATOM   452  C CG  . LYS A 1 96  ? 132.93340 -9.80941  17.30447  1.000 32.03572  ? 95  LYS A CG  1 
ATOM   453  C CD  . LYS A 1 96  ? 131.64908 -10.48078 16.83248  1.000 35.84749  ? 95  LYS A CD  1 
ATOM   454  C CE  . LYS A 1 96  ? 131.58453 -11.94535 17.22094  1.000 41.78194  ? 95  LYS A CE  1 
ATOM   455  N NZ  . LYS A 1 96  ? 131.58342 -12.14013 18.70348  1.000 53.73235  ? 95  LYS A NZ  1 
ATOM   456  N N   . VAL A 1 97  ? 137.04336 -9.60625  14.94954  1.000 26.39310  ? 96  VAL A N   1 
ATOM   457  C CA  . VAL A 1 97  ? 138.19351 -10.25351 14.31845  1.000 26.18275  ? 96  VAL A CA  1 
ATOM   458  C C   . VAL A 1 97  ? 139.44880 -9.39176  14.34879  1.000 26.77182  ? 96  VAL A C   1 
ATOM   459  O O   . VAL A 1 97  ? 140.51262 -9.85677  13.92014  1.000 30.86868  ? 96  VAL A O   1 
ATOM   460  C CB  . VAL A 1 97  ? 137.89923 -10.66038 12.85705  1.000 27.48951  ? 96  VAL A CB  1 
ATOM   461  C CG1 . VAL A 1 97  ? 136.71946 -11.64919 12.78588  1.000 24.66321  ? 96  VAL A CG1 1 
ATOM   462  C CG2 . VAL A 1 97  ? 137.65478 -9.42521  11.99589  1.000 27.08146  ? 96  VAL A CG2 1 
ATOM   463  N N   . SER A 1 98  ? 139.37024 -8.15953  14.84008  1.000 26.70668  ? 97  SER A N   1 
ATOM   464  C CA  . SER A 1 98  ? 140.50679 -7.25261  14.73328  1.000 31.21602  ? 97  SER A CA  1 
ATOM   465  C C   . SER A 1 98  ? 141.42231 -7.27684  15.95174  1.000 37.04078  ? 97  SER A C   1 
ATOM   466  O O   . SER A 1 98  ? 142.33542 -6.45079  16.03209  1.000 39.89087  ? 97  SER A O   1 
ATOM   467  C CB  . SER A 1 98  ? 140.02910 -5.81855  14.48298  1.000 31.24522  ? 97  SER A CB  1 
ATOM   468  O OG  . SER A 1 98  ? 139.49374 -5.67397  13.17542  1.000 28.20935  ? 97  SER A OG  1 
ATOM   469  N N   . SER A 1 99  ? 141.21545 -8.18742  16.89766  1.000 38.05151  ? 98  SER A N   1 
ATOM   470  C CA  . SER A 1 99  ? 142.10518 -8.27446  18.05242  1.000 44.93488  ? 98  SER A CA  1 
ATOM   471  C C   . SER A 1 99  ? 143.30505 -9.14789  17.70086  1.000 42.66309  ? 98  SER A C   1 
ATOM   472  O O   . SER A 1 99  ? 143.14346 -10.25920 17.18571  1.000 45.23774  ? 98  SER A O   1 
ATOM   473  C CB  . SER A 1 99  ? 141.37252 -8.83045  19.27624  1.000 46.72927  ? 98  SER A CB  1 
ATOM   474  N N   . GLY A 1 100 ? 144.50364 -8.63564  17.96555  1.000 44.00815  ? 99  GLY A N   1 
ATOM   475  C CA  . GLY A 1 100 ? 145.72140 -9.36512  17.66898  1.000 44.06365  ? 99  GLY A CA  1 
ATOM   476  C C   . GLY A 1 100 ? 146.01796 -9.38919  16.17771  1.000 48.89054  ? 99  GLY A C   1 
ATOM   477  O O   . GLY A 1 100 ? 145.30235 -8.82231  15.35552  1.000 45.35427  ? 99  GLY A O   1 
ATOM   478  N N   . PHE A 1 101 ? 147.10818 -10.07316 15.83369  1.000 42.98239  ? 100 PHE A N   1 
ATOM   479  C CA  . PHE A 1 101 ? 147.51709 -10.19799 14.44220  1.000 40.84628  ? 100 PHE A CA  1 
ATOM   480  C C   . PHE A 1 101 ? 146.73438 -11.30580 13.74970  1.000 40.11753  ? 100 PHE A C   1 
ATOM   481  O O   . PHE A 1 101 ? 146.40483 -12.33210 14.35052  1.000 40.26429  ? 100 PHE A O   1 
ATOM   482  C CB  . PHE A 1 101 ? 149.01171 -10.50347 14.34101  1.000 47.13594  ? 100 PHE A CB  1 
ATOM   483  C CG  . PHE A 1 101 ? 149.88983 -9.48591  15.00440  1.000 49.75058  ? 100 PHE A CG  1 
ATOM   484  C CD1 . PHE A 1 101 ? 150.12534 -8.25774  14.40703  1.000 51.00846  ? 100 PHE A CD1 1 
ATOM   485  C CD2 . PHE A 1 101 ? 150.49395 -9.76435  16.21792  1.000 50.69004  ? 100 PHE A CD2 1 
ATOM   486  C CE1 . PHE A 1 101 ? 150.94333 -7.32302  15.01490  1.000 54.16670  ? 100 PHE A CE1 1 
ATOM   487  C CE2 . PHE A 1 101 ? 151.31502 -8.83438  16.83213  1.000 54.59096  ? 100 PHE A CE2 1 
ATOM   488  C CZ  . PHE A 1 101 ? 151.53961 -7.61263  16.22955  1.000 56.64399  ? 100 PHE A CZ  1 
ATOM   489  N N   . SER A 1 102 ? 146.45502 -11.10419 12.46806  1.000 32.23559  ? 101 SER A N   1 
ATOM   490  C CA  . SER A 1 102 ? 145.76845 -12.12686 11.68776  1.000 39.53112  ? 101 SER A CA  1 
ATOM   491  C C   . SER A 1 102 ? 145.81243 -11.71712 10.22067  1.000 34.96443  ? 101 SER A C   1 
ATOM   492  O O   . SER A 1 102 ? 146.30529 -10.64141 9.86740   1.000 36.47980  ? 101 SER A O   1 
ATOM   493  C CB  . SER A 1 102 ? 144.32609 -12.31841 12.15758  1.000 36.37361  ? 101 SER A CB  1 
ATOM   494  O OG  . SER A 1 102 ? 143.53635 -11.21041 11.75346  1.000 37.68627  ? 101 SER A OG  1 
ATOM   495  N N   . GLY A 1 103 ? 145.28226 -12.59046 9.37110   1.000 30.62858  ? 102 GLY A N   1 
ATOM   496  C CA  . GLY A 1 103 ? 145.14518 -12.29787 7.96531   1.000 23.57689  ? 102 GLY A CA  1 
ATOM   497  C C   . GLY A 1 103 ? 143.85833 -11.57747 7.62933   1.000 26.07482  ? 102 GLY A C   1 
ATOM   498  O O   . GLY A 1 103 ? 143.26231 -11.84242 6.58646   1.000 24.28257  ? 102 GLY A O   1 
ATOM   499  N N   A VAL A 1 104 ? 143.42710 -10.66179 8.49905   0.540 25.72733  ? 103 VAL A N   1 
ATOM   500  N N   B VAL A 1 104 ? 143.38408 -10.70039 8.51103   0.460 25.72924  ? 103 VAL A N   1 
ATOM   501  C CA  A VAL A 1 104 ? 142.25482 -9.82201  8.26908   0.540 26.37319  ? 103 VAL A CA  1 
ATOM   502  C CA  B VAL A 1 104 ? 142.26336 -9.82511  8.19242   0.460 26.36124  ? 103 VAL A CA  1 
ATOM   503  C C   A VAL A 1 104 ? 142.69347 -8.36670  8.36295   0.540 26.56386  ? 103 VAL A C   1 
ATOM   504  C C   B VAL A 1 104 ? 142.74446 -8.38771  8.30469   0.460 26.54457  ? 103 VAL A C   1 
ATOM   505  O O   A VAL A 1 104 ? 143.42775 -8.00465  9.28930   0.540 27.63304  ? 103 VAL A O   1 
ATOM   506  O O   B VAL A 1 104 ? 143.57467 -8.06565  9.16203   0.460 27.70109  ? 103 VAL A O   1 
ATOM   507  C CB  A VAL A 1 104 ? 141.14169 -10.12292 9.29203   0.540 27.77302  ? 103 VAL A CB  1 
ATOM   508  C CB  B VAL A 1 104 ? 141.03492 -10.07349 9.09851   0.460 27.82104  ? 103 VAL A CB  1 
ATOM   509  C CG1 A VAL A 1 104 ? 139.93835 -9.22932  9.05897   0.540 25.64048  ? 103 VAL A CG1 1 
ATOM   510  C CG1 B VAL A 1 104 ? 140.66689 -11.55322 9.11849   0.460 26.20767  ? 103 VAL A CG1 1 
ATOM   511  C CG2 A VAL A 1 104 ? 140.73997 -11.59118 9.23408   0.540 26.20789  ? 103 VAL A CG2 1 
ATOM   512  C CG2 B VAL A 1 104 ? 141.26966 -9.55458  10.50178  0.460 27.12286  ? 103 VAL A CG2 1 
ATOM   513  N N   . ILE A 1 105 ? 142.25094 -7.53467  7.41146   1.000 23.67340  ? 104 ILE A N   1 
ATOM   514  C CA  . ILE A 1 105 ? 142.51228 -6.09985  7.51306   1.000 27.27871  ? 104 ILE A CA  1 
ATOM   515  C C   . ILE A 1 105 ? 141.78001 -5.59612  8.75154   1.000 28.29852  ? 104 ILE A C   1 
ATOM   516  O O   . ILE A 1 105 ? 140.55928 -5.75404  8.87204   1.000 29.13232  ? 104 ILE A O   1 
ATOM   517  C CB  . ILE A 1 105 ? 142.06579 -5.34931  6.24537   1.000 26.09119  ? 104 ILE A CB  1 
ATOM   518  C CG1 . ILE A 1 105 ? 143.01421 -5.59240  5.05687   1.000 27.09698  ? 104 ILE A CG1 1 
ATOM   519  C CG2 . ILE A 1 105 ? 141.90945 -3.83040  6.51914   1.000 25.22957  ? 104 ILE A CG2 1 
ATOM   520  C CD1 . ILE A 1 105 ? 144.43470 -5.07916  5.24811   1.000 30.14285  ? 104 ILE A CD1 1 
ATOM   521  N N   . ARG A 1 106 ? 142.52387 -5.01411  9.69061   1.000 26.25124  ? 105 ARG A N   1 
ATOM   522  C CA  . ARG A 1 106 ? 141.98235 -4.68976  11.00546  1.000 29.79666  ? 105 ARG A CA  1 
ATOM   523  C C   . ARG A 1 106 ? 141.29825 -3.32821  11.02240  1.000 28.13102  ? 105 ARG A C   1 
ATOM   524  O O   . ARG A 1 106 ? 141.73600 -2.38443  10.36258  1.000 26.82390  ? 105 ARG A O   1 
ATOM   525  C CB  . ARG A 1 106 ? 143.09551 -4.73882  12.05717  1.000 29.79519  ? 105 ARG A CB  1 
ATOM   526  C CG  . ARG A 1 106 ? 143.67227 -6.15654  12.19891  1.000 32.80863  ? 105 ARG A CG  1 
ATOM   527  C CD  . ARG A 1 106 ? 144.94133 -6.19214  13.02864  1.000 40.55717  ? 105 ARG A CD  1 
ATOM   528  N NE  . ARG A 1 106 ? 144.67451 -5.90217  14.43087  1.000 51.07177  ? 105 ARG A NE  1 
ATOM   529  C CZ  . ARG A 1 106 ? 145.60909 -5.77149  15.36434  1.000 56.44978  ? 105 ARG A CZ  1 
ATOM   530  N NH1 . ARG A 1 106 ? 146.89666 -5.88834  15.07691  1.000 52.76888  ? 105 ARG A NH1 1 
ATOM   531  N NH2 . ARG A 1 106 ? 145.24167 -5.51701  16.61828  1.000 53.86195  ? 105 ARG A NH2 1 
ATOM   532  N N   . LEU A 1 107 ? 140.20683 -3.24471  11.77403  1.000 27.15296  ? 106 LEU A N   1 
ATOM   533  C CA  . LEU A 1 107 ? 139.53085 -1.97431  12.00708  1.000 26.58840  ? 106 LEU A CA  1 
ATOM   534  C C   . LEU A 1 107 ? 140.25894 -1.21262  13.10697  1.000 30.38648  ? 106 LEU A C   1 
ATOM   535  O O   . LEU A 1 107 ? 140.38458 -1.70794  14.22978  1.000 28.23814  ? 106 LEU A O   1 
ATOM   536  C CB  . LEU A 1 107 ? 138.07579 -2.21124  12.39131  1.000 26.13882  ? 106 LEU A CB  1 
ATOM   537  C CG  . LEU A 1 107 ? 137.25037 -0.94571  12.64553  1.000 28.84688  ? 106 LEU A CG  1 
ATOM   538  C CD1 . LEU A 1 107 ? 136.95563 -0.20968  11.33664  1.000 28.60761  ? 106 LEU A CD1 1 
ATOM   539  C CD2 . LEU A 1 107 ? 135.96878 -1.30558  13.38612  1.000 30.57036  ? 106 LEU A CD2 1 
ATOM   540  N N   . LEU A 1 108 ? 140.74353 -0.01547  12.78952  1.000 29.00172  ? 107 LEU A N   1 
ATOM   541  C CA  . LEU A 1 108 ? 141.49938 0.76270   13.76567  1.000 32.32265  ? 107 LEU A CA  1 
ATOM   542  C C   . LEU A 1 108 ? 140.63512 1.74497   14.54032  1.000 34.77521  ? 107 LEU A C   1 
ATOM   543  O O   . LEU A 1 108 ? 140.95393 2.06198   15.69103  1.000 33.28270  ? 107 LEU A O   1 
ATOM   544  C CB  . LEU A 1 108 ? 142.62723 1.52653   13.06569  1.000 31.62567  ? 107 LEU A CB  1 
ATOM   545  C CG  . LEU A 1 108 ? 143.56945 0.64372   12.24321  1.000 32.96061  ? 107 LEU A CG  1 
ATOM   546  C CD1 . LEU A 1 108 ? 144.57933 1.48291   11.46509  1.000 35.56352  ? 107 LEU A CD1 1 
ATOM   547  C CD2 . LEU A 1 108 ? 144.26662 -0.37377  13.12138  1.000 36.00175  ? 107 LEU A CD2 1 
ATOM   548  N N   . ASP A 1 109 ? 139.56049 2.23846   13.93322  1.000 30.00335  ? 108 ASP A N   1 
ATOM   549  C CA  . ASP A 1 109 ? 138.67221 3.21438   14.54958  1.000 33.76283  ? 108 ASP A CA  1 
ATOM   550  C C   . ASP A 1 109 ? 137.44952 3.33447   13.65304  1.000 35.15971  ? 108 ASP A C   1 
ATOM   551  O O   . ASP A 1 109 ? 137.44965 2.86249   12.51197  1.000 31.89568  ? 108 ASP A O   1 
ATOM   552  C CB  . ASP A 1 109 ? 139.36504 4.57043   14.72172  1.000 36.07847  ? 108 ASP A CB  1 
ATOM   553  C CG  . ASP A 1 109 ? 138.68929 5.45781   15.76888  1.000 43.50548  ? 108 ASP A CG  1 
ATOM   554  O OD1 . ASP A 1 109 ? 137.82084 4.97380   16.52864  1.000 39.41908  ? 108 ASP A OD1 1 
ATOM   555  O OD2 . ASP A 1 109 ? 139.03301 6.65006   15.82058  1.000 44.46695  ? 108 ASP A OD2 1 
ATOM   556  N N   . TRP A 1 110 ? 136.40689 3.97639   14.17655  1.000 29.43213  ? 109 TRP A N   1 
ATOM   557  C CA  . TRP A 1 110 ? 135.22045 4.24557   13.37451  1.000 35.39815  ? 109 TRP A CA  1 
ATOM   558  C C   . TRP A 1 110 ? 134.49960 5.45444   13.95006  1.000 38.81146  ? 109 TRP A C   1 
ATOM   559  O O   . TRP A 1 110 ? 134.66046 5.79842   15.12628  1.000 35.97702  ? 109 TRP A O   1 
ATOM   560  C CB  . TRP A 1 110 ? 134.28510 3.03147   13.31519  1.000 30.26098  ? 109 TRP A CB  1 
ATOM   561  C CG  . TRP A 1 110 ? 133.77712 2.62262   14.66273  1.000 34.18670  ? 109 TRP A CG  1 
ATOM   562  C CD1 . TRP A 1 110 ? 134.36207 1.75136   15.53057  1.000 35.48714  ? 109 TRP A CD1 1 
ATOM   563  C CD2 . TRP A 1 110 ? 132.58339 3.08607   15.29796  1.000 37.81458  ? 109 TRP A CD2 1 
ATOM   564  N NE1 . TRP A 1 110 ? 133.60040 1.64055   16.67698  1.000 37.95139  ? 109 TRP A NE1 1 
ATOM   565  C CE2 . TRP A 1 110 ? 132.50454 2.45382   16.55668  1.000 39.02679  ? 109 TRP A CE2 1 
ATOM   566  C CE3 . TRP A 1 110 ? 131.57346 3.97824   14.92668  1.000 43.53064  ? 109 TRP A CE3 1 
ATOM   567  C CZ2 . TRP A 1 110 ? 131.45518 2.68325   17.44198  1.000 45.70800  ? 109 TRP A CZ2 1 
ATOM   568  C CZ3 . TRP A 1 110 ? 130.53188 4.20600   15.81124  1.000 48.41215  ? 109 TRP A CZ3 1 
ATOM   569  C CH2 . TRP A 1 110 ? 130.48174 3.56098   17.05256  1.000 45.12671  ? 109 TRP A CH2 1 
ATOM   570  N N   . PHE A 1 111 ? 133.69602 6.09011   13.10007  1.000 33.30160  ? 110 PHE A N   1 
ATOM   571  C CA  . PHE A 1 111 ? 132.99967 7.32528   13.43546  1.000 37.89490  ? 110 PHE A CA  1 
ATOM   572  C C   . PHE A 1 111 ? 131.58407 7.25304   12.89610  1.000 40.84518  ? 110 PHE A C   1 
ATOM   573  O O   . PHE A 1 111 ? 131.34090 6.66512   11.84043  1.000 35.99310  ? 110 PHE A O   1 
ATOM   574  C CB  . PHE A 1 111 ? 133.68512 8.56553   12.83457  1.000 37.81393  ? 110 PHE A CB  1 
ATOM   575  C CG  . PHE A 1 111 ? 135.11947 8.72153   13.23094  1.000 46.99029  ? 110 PHE A CG  1 
ATOM   576  C CD1 . PHE A 1 111 ? 136.11671 8.03053   12.56177  1.000 45.83682  ? 110 PHE A CD1 1 
ATOM   577  C CD2 . PHE A 1 111 ? 135.47545 9.57366   14.26774  1.000 56.47615  ? 110 PHE A CD2 1 
ATOM   578  C CE1 . PHE A 1 111 ? 137.44544 8.17040   12.92711  1.000 47.91705  ? 110 PHE A CE1 1 
ATOM   579  C CE2 . PHE A 1 111 ? 136.80050 9.72598   14.63955  1.000 58.53476  ? 110 PHE A CE2 1 
ATOM   580  C CZ  . PHE A 1 111 ? 137.78917 9.02492   13.96815  1.000 61.12164  ? 110 PHE A CZ  1 
ATOM   581  N N   . GLU A 1 112 ? 130.65199 7.87674   13.60485  1.000 34.55816  ? 111 GLU A N   1 
ATOM   582  C CA  . GLU A 1 112 ? 129.29923 8.04406   13.09137  1.000 37.60384  ? 111 GLU A CA  1 
ATOM   583  C C   . GLU A 1 112 ? 129.11578 9.47531   12.61554  1.000 40.69823  ? 111 GLU A C   1 
ATOM   584  O O   . GLU A 1 112 ? 129.51022 10.42131  13.30505  1.000 40.42233  ? 111 GLU A O   1 
ATOM   585  C CB  . GLU A 1 112 ? 128.24036 7.70362   14.14042  1.000 38.40200  ? 111 GLU A CB  1 
ATOM   586  C CG  . GLU A 1 112 ? 126.81298 7.93453   13.64212  1.000 37.80830  ? 111 GLU A CG  1 
ATOM   587  C CD  . GLU A 1 112 ? 125.76423 7.37833   14.58789  1.000 46.11048  ? 111 GLU A CD  1 
ATOM   588  O OE1 . GLU A 1 112 ? 126.13174 6.97550   15.70934  1.000 45.53080  ? 111 GLU A OE1 1 
ATOM   589  O OE2 . GLU A 1 112 ? 124.57755 7.33359   14.20358  1.000 50.71776  ? 111 GLU A OE2 1 
ATOM   590  N N   . ARG A 1 113 ? 128.53008 9.62157   11.43369  1.000 36.39160  ? 112 ARG A N   1 
ATOM   591  C CA  . ARG A 1 113 ? 128.18185 10.90176  10.84480  1.000 39.45966  ? 112 ARG A CA  1 
ATOM   592  C C   . ARG A 1 113 ? 126.66481 10.94107  10.71348  1.000 39.48942  ? 112 ARG A C   1 
ATOM   593  O O   . ARG A 1 113 ? 126.01505 9.90384   10.89739  1.000 40.10515  ? 112 ARG A O   1 
ATOM   594  C CB  . ARG A 1 113 ? 128.87818 11.07169  9.49108   1.000 36.34602  ? 112 ARG A CB  1 
ATOM   595  C CG  . ARG A 1 113 ? 130.31007 11.56063  9.60526   1.000 40.06630  ? 112 ARG A CG  1 
ATOM   596  C CD  . ARG A 1 113 ? 130.96533 11.63443  8.24162   1.000 39.14640  ? 112 ARG A CD  1 
ATOM   597  N NE  . ARG A 1 113 ? 132.12414 12.51874  8.23001   1.000 45.23593  ? 112 ARG A NE  1 
ATOM   598  C CZ  . ARG A 1 113 ? 132.84602 12.77345  7.14756   1.000 41.68242  ? 112 ARG A CZ  1 
ATOM   599  N NH1 . ARG A 1 113 ? 132.56430 12.20975  5.98641   1.000 34.20565  ? 112 ARG A NH1 1 
ATOM   600  N NH2 . ARG A 1 113 ? 133.87155 13.61804  7.23200   1.000 47.57361  ? 112 ARG A NH2 1 
ATOM   601  N N   . PRO A 1 114 ? 126.06114 12.10112  10.42580  1.000 42.84650  ? 113 PRO A N   1 
ATOM   602  C CA  . PRO A 1 114 ? 124.59668 12.13585  10.26150  1.000 45.08699  ? 113 PRO A CA  1 
ATOM   603  C C   . PRO A 1 114 ? 124.03727 11.07471  9.32697   1.000 42.01113  ? 113 PRO A C   1 
ATOM   604  O O   . PRO A 1 114 ? 123.05755 10.40702  9.67634   1.000 49.85816  ? 113 PRO A O   1 
ATOM   605  C CB  . PRO A 1 114 ? 124.35607 13.55192  9.72470   1.000 46.10823  ? 113 PRO A CB  1 
ATOM   606  C CG  . PRO A 1 114 ? 125.43501 14.35909  10.35064  1.000 47.31418  ? 113 PRO A CG  1 
ATOM   607  C CD  . PRO A 1 114 ? 126.64550 13.45674  10.39258  1.000 43.72340  ? 113 PRO A CD  1 
ATOM   608  N N   . ASP A 1 115 ? 124.63883 10.88144  8.15262   1.000 40.82244  ? 114 ASP A N   1 
ATOM   609  C CA  . ASP A 1 115 ? 124.06534 9.99861   7.14492   1.000 40.67899  ? 114 ASP A CA  1 
ATOM   610  C C   . ASP A 1 115 ? 124.94060 8.79539   6.82447   1.000 39.54186  ? 114 ASP A C   1 
ATOM   611  O O   . ASP A 1 115 ? 124.63832 8.06359   5.87460   1.000 40.00890  ? 114 ASP A O   1 
ATOM   612  C CB  . ASP A 1 115 ? 123.77982 10.79378  5.86855   1.000 45.94684  ? 114 ASP A CB  1 
ATOM   613  C CG  . ASP A 1 115 ? 122.81469 11.93934  6.11164   1.000 59.30634  ? 114 ASP A CG  1 
ATOM   614  O OD1 . ASP A 1 115 ? 121.71749 11.67530  6.65038   1.000 52.53491  ? 114 ASP A OD1 1 
ATOM   615  O OD2 . ASP A 1 115 ? 123.16280 13.09959  5.79678   1.000 58.79887  ? 114 ASP A OD2 1 
ATOM   616  N N   . SER A 1 116 ? 126.00042 8.55390   7.59170   1.000 40.13467  ? 115 SER A N   1 
ATOM   617  C CA  . SER A 1 116 ? 126.95283 7.52147   7.20448   1.000 38.47592  ? 115 SER A CA  1 
ATOM   618  C C   . SER A 1 116 ? 127.78777 7.11227   8.40539   1.000 36.35949  ? 115 SER A C   1 
ATOM   619  O O   . SER A 1 116 ? 127.82563 7.80231   9.42470   1.000 34.12008  ? 115 SER A O   1 
ATOM   620  C CB  . SER A 1 116 ? 127.87212 8.01643   6.08737   1.000 33.78093  ? 115 SER A CB  1 
ATOM   621  O OG  . SER A 1 116 ? 128.59808 9.14894   6.52690   1.000 31.22085  ? 115 SER A OG  1 
ATOM   622  N N   . PHE A 1 117 ? 128.46403 5.97667   8.26342   1.000 28.01590  ? 116 PHE A N   1 
ATOM   623  C CA  . PHE A 1 117 ? 129.53241 5.59009   9.16971   1.000 29.75010  ? 116 PHE A CA  1 
ATOM   624  C C   . PHE A 1 117 ? 130.85287 5.62772   8.41601   1.000 34.60971  ? 116 PHE A C   1 
ATOM   625  O O   . PHE A 1 117 ? 130.89675 5.39322   7.20767   1.000 30.68365  ? 116 PHE A O   1 
ATOM   626  C CB  . PHE A 1 117 ? 129.29695 4.19332   9.74385   1.000 29.69831  ? 116 PHE A CB  1 
ATOM   627  C CG  . PHE A 1 117 ? 128.22112 4.14832   10.79833  1.000 33.90373  ? 116 PHE A CG  1 
ATOM   628  C CD1 . PHE A 1 117 ? 126.89284 4.01022   10.44274  1.000 34.86262  ? 116 PHE A CD1 1 
ATOM   629  C CD2 . PHE A 1 117 ? 128.54618 4.24336   12.14243  1.000 36.98818  ? 116 PHE A CD2 1 
ATOM   630  C CE1 . PHE A 1 117 ? 125.90388 3.97117   11.41069  1.000 40.86139  ? 116 PHE A CE1 1 
ATOM   631  C CE2 . PHE A 1 117 ? 127.55668 4.19129   13.12187  1.000 39.79319  ? 116 PHE A CE2 1 
ATOM   632  C CZ  . PHE A 1 117 ? 126.23887 4.06074   12.74828  1.000 37.86855  ? 116 PHE A CZ  1 
ATOM   633  N N   . VAL A 1 118 ? 131.92794 5.94065   9.12765   1.000 28.53308  ? 117 VAL A N   1 
ATOM   634  C CA  . VAL A 1 118 ? 133.26261 5.97953   8.54028   1.000 28.96117  ? 117 VAL A CA  1 
ATOM   635  C C   . VAL A 1 118 ? 134.13096 4.99460   9.30364   1.000 29.86328  ? 117 VAL A C   1 
ATOM   636  O O   . VAL A 1 118 ? 134.23854 5.08047   10.53569  1.000 29.98695  ? 117 VAL A O   1 
ATOM   637  C CB  . VAL A 1 118 ? 133.87200 7.39027   8.57556   1.000 29.57252  ? 117 VAL A CB  1 
ATOM   638  C CG1 . VAL A 1 118 ? 135.23053 7.39201   7.89846   1.000 33.13028  ? 117 VAL A CG1 1 
ATOM   639  C CG2 . VAL A 1 118 ? 132.93586 8.39611   7.91995   1.000 30.08258  ? 117 VAL A CG2 1 
ATOM   640  N N   . LEU A 1 119 ? 134.74508 4.06451   8.57766   1.000 27.52347  ? 118 LEU A N   1 
ATOM   641  C CA  . LEU A 1 119 ? 135.59738 3.03128   9.15123   1.000 26.33704  ? 118 LEU A CA  1 
ATOM   642  C C   . LEU A 1 119 ? 137.04357 3.30477   8.76933   1.000 29.24441  ? 118 LEU A C   1 
ATOM   643  O O   . LEU A 1 119 ? 137.34151 3.54123   7.59246   1.000 27.42821  ? 118 LEU A O   1 
ATOM   644  C CB  . LEU A 1 119 ? 135.18334 1.64399   8.65417   1.000 23.49395  ? 118 LEU A CB  1 
ATOM   645  C CG  . LEU A 1 119 ? 133.95892 0.95748   9.27816   1.000 32.82796  ? 118 LEU A CG  1 
ATOM   646  C CD1 . LEU A 1 119 ? 132.69663 1.79981   9.20640   1.000 33.31889  ? 118 LEU A CD1 1 
ATOM   647  C CD2 . LEU A 1 119 ? 133.73244 -0.39463  8.60252   1.000 30.39934  ? 118 LEU A CD2 1 
ATOM   648  N N   . ILE A 1 120 ? 137.93703 3.25399   9.75263   1.000 28.51394  ? 119 ILE A N   1 
ATOM   649  C CA  . ILE A 1 120 ? 139.36918 3.43324   9.52910   1.000 28.30647  ? 119 ILE A CA  1 
ATOM   650  C C   . ILE A 1 120 ? 140.02968 2.06205   9.59370   1.000 26.62436  ? 119 ILE A C   1 
ATOM   651  O O   . ILE A 1 120 ? 139.99973 1.39932   10.63940  1.000 27.56887  ? 119 ILE A O   1 
ATOM   652  C CB  . ILE A 1 120 ? 139.99348 4.39008   10.56036  1.000 31.41808  ? 119 ILE A CB  1 
ATOM   653  C CG1 . ILE A 1 120 ? 139.21457 5.70727   10.63146  1.000 31.49844  ? 119 ILE A CG1 1 
ATOM   654  C CG2 . ILE A 1 120 ? 141.46265 4.62829   10.22286  1.000 33.01309  ? 119 ILE A CG2 1 
ATOM   655  C CD1 . ILE A 1 120 ? 139.18710 6.48231   9.32003   1.000 31.99509  ? 119 ILE A CD1 1 
ATOM   656  N N   . LEU A 1 121 ? 140.64736 1.64782   8.48593   1.000 28.86475  ? 120 LEU A N   1 
ATOM   657  C CA  . LEU A 1 121 ? 141.17848 0.30309   8.31325   1.000 29.88452  ? 120 LEU A CA  1 
ATOM   658  C C   . LEU A 1 121 ? 142.67285 0.34835   8.01307   1.000 30.23165  ? 120 LEU A C   1 
ATOM   659  O O   . LEU A 1 121 ? 143.17664 1.32469   7.45401   1.000 30.70239  ? 120 LEU A O   1 
ATOM   660  C CB  . LEU A 1 121 ? 140.44948 -0.42751  7.16171   1.000 27.95012  ? 120 LEU A CB  1 
ATOM   661  C CG  . LEU A 1 121 ? 138.93115 -0.51236  7.34669   1.000 27.96759  ? 120 LEU A CG  1 
ATOM   662  C CD1 . LEU A 1 121 ? 138.22769 -0.56552  5.99986   1.000 34.20831  ? 120 LEU A CD1 1 
ATOM   663  C CD2 . LEU A 1 121 ? 138.55826 -1.72273  8.22047   1.000 28.66157  ? 120 LEU A CD2 1 
ATOM   664  N N   . GLU A 1 122 ? 143.37186 -0.73341  8.37632   1.000 28.55225  ? 121 GLU A N   1 
ATOM   665  C CA  . GLU A 1 122 ? 144.77754 -0.89414  8.01805   1.000 33.40970  ? 121 GLU A CA  1 
ATOM   666  C C   . GLU A 1 122 ? 144.97213 -0.74908  6.51673   1.000 28.27510  ? 121 GLU A C   1 
ATOM   667  O O   . GLU A 1 122 ? 144.11224 -1.12849  5.72118   1.000 30.02075  ? 121 GLU A O   1 
ATOM   668  C CB  . GLU A 1 122 ? 145.29178 -2.27427  8.43207   1.000 29.58088  ? 121 GLU A CB  1 
ATOM   669  C CG  . GLU A 1 122 ? 145.44655 -2.48785  9.90861   1.000 36.32185  ? 121 GLU A CG  1 
ATOM   670  C CD  . GLU A 1 122 ? 146.02799 -3.85800  10.20579  1.000 47.48950  ? 121 GLU A CD  1 
ATOM   671  O OE1 . GLU A 1 122 ? 145.56874 -4.85727  9.58544   1.000 35.70934  ? 121 GLU A OE1 1 
ATOM   672  O OE2 . GLU A 1 122 ? 146.95680 -3.92557  11.04290  1.000 52.91792  ? 121 GLU A OE2 1 
ATOM   673  N N   . ARG A 1 123 ? 146.12760 -0.21751  6.12226   1.000 34.08837  ? 122 ARG A N   1 
ATOM   674  C CA  . ARG A 1 123 ? 146.49284 -0.14918  4.70904   1.000 36.14670  ? 122 ARG A CA  1 
ATOM   675  C C   . ARG A 1 123 ? 147.93207 -0.60163  4.54055   1.000 35.36810  ? 122 ARG A C   1 
ATOM   676  O O   . ARG A 1 123 ? 148.87006 0.18753   4.70039   1.000 33.00857  ? 122 ARG A O   1 
ATOM   677  C CB  . ARG A 1 123 ? 146.29903 1.25508   4.13414   1.000 33.86320  ? 122 ARG A CB  1 
ATOM   678  C CG  . ARG A 1 123 ? 146.65785 1.34767   2.65711   1.000 37.72244  ? 122 ARG A CG  1 
ATOM   679  C CD  . ARG A 1 123 ? 146.08753 2.60760   2.01071   1.000 36.16502  ? 122 ARG A CD  1 
ATOM   680  N NE  . ARG A 1 123 ? 146.66341 3.82266   2.57543   1.000 34.89534  ? 122 ARG A NE  1 
ATOM   681  C CZ  . ARG A 1 123 ? 147.81820 4.34056   2.17931   1.000 42.01603  ? 122 ARG A CZ  1 
ATOM   682  N NH1 . ARG A 1 123 ? 148.55115 3.75632   1.24128   1.000 41.23115  ? 122 ARG A NH1 1 
ATOM   683  N NH2 . ARG A 1 123 ? 148.24730 5.46934   2.73296   1.000 38.81958  ? 122 ARG A NH2 1 
ATOM   684  N N   . PRO A 1 124 ? 148.14755 -1.87714  4.24078   1.000 38.20013  ? 123 PRO A N   1 
ATOM   685  C CA  . PRO A 1 124 ? 149.48131 -2.30786  3.81886   1.000 36.97323  ? 123 PRO A CA  1 
ATOM   686  C C   . PRO A 1 124 ? 149.84512 -1.67962  2.48442   1.000 37.18435  ? 123 PRO A C   1 
ATOM   687  O O   . PRO A 1 124 ? 148.98351 -1.31115  1.68002   1.000 35.43756  ? 123 PRO A O   1 
ATOM   688  C CB  . PRO A 1 124 ? 149.35424 -3.83340  3.71063   1.000 43.69475  ? 123 PRO A CB  1 
ATOM   689  C CG  . PRO A 1 124 ? 147.87814 -4.11752  3.69881   1.000 45.47932  ? 123 PRO A CG  1 
ATOM   690  C CD  . PRO A 1 124 ? 147.23933 -3.01225  4.47328   1.000 40.40200  ? 123 PRO A CD  1 
ATOM   691  N N   . GLU A 1 125 ? 151.15001 -1.54629  2.26083   1.000 36.75857  ? 124 GLU A N   1 
ATOM   692  C CA  . GLU A 1 125 ? 151.65858 -0.90598  1.07019   1.000 36.22516  ? 124 GLU A CA  1 
ATOM   693  C C   . GLU A 1 125 ? 153.00328 -1.55345  0.76004   1.000 43.31643  ? 124 GLU A C   1 
ATOM   694  O O   . GLU A 1 125 ? 153.81855 -1.72054  1.68152   1.000 44.60913  ? 124 GLU A O   1 
ATOM   695  C CB  . GLU A 1 125 ? 151.81469 0.60694   1.26802   1.000 37.39317  ? 124 GLU A CB  1 
ATOM   696  C CG  . GLU A 1 125 ? 152.72594 1.30893   0.25777   1.000 51.42846  ? 124 GLU A CG  1 
ATOM   697  C CD  . GLU A 1 125 ? 152.10597 1.45197   -1.13183  1.000 59.27654  ? 124 GLU A CD  1 
ATOM   698  O OE1 . GLU A 1 125 ? 150.87501 1.26474   -1.26518  1.000 52.19009  ? 124 GLU A OE1 1 
ATOM   699  O OE2 . GLU A 1 125 ? 152.85562 1.75359   -2.09181  1.000 61.62489  ? 124 GLU A OE2 1 
ATOM   700  N N   . PRO A 1 126 ? 153.24886 -1.97075  -0.49083  1.000 42.24556  ? 125 PRO A N   1 
ATOM   701  C CA  . PRO A 1 126 ? 152.33898 -1.94876  -1.64330  1.000 35.59826  ? 125 PRO A CA  1 
ATOM   702  C C   . PRO A 1 126 ? 151.36826 -3.11891  -1.61262  1.000 37.24390  ? 125 PRO A C   1 
ATOM   703  O O   . PRO A 1 126 ? 151.68448 -4.17595  -1.05778  1.000 31.64606  ? 125 PRO A O   1 
ATOM   704  C CB  . PRO A 1 126 ? 153.29737 -2.04597  -2.83381  1.000 34.73716  ? 125 PRO A CB  1 
ATOM   705  C CG  . PRO A 1 126 ? 154.40621 -2.91695  -2.31142  1.000 37.38288  ? 125 PRO A CG  1 
ATOM   706  C CD  . PRO A 1 126 ? 154.56521 -2.52539  -0.85332  1.000 43.87291  ? 125 PRO A CD  1 
ATOM   707  N N   A VAL A 1 127 ? 150.21041 -2.97329  -2.26364  0.570 31.10704  ? 126 VAL A N   1 
ATOM   708  N N   B VAL A 1 127 ? 150.17510 -2.96050  -2.18586  0.430 31.17886  ? 126 VAL A N   1 
ATOM   709  C CA  A VAL A 1 127 ? 149.11367 -3.92879  -2.16634  0.570 29.99843  ? 126 VAL A CA  1 
ATOM   710  C CA  B VAL A 1 127 ? 149.17557 -4.01653  -2.19305  0.430 29.98410  ? 126 VAL A CA  1 
ATOM   711  C C   A VAL A 1 127 ? 148.46980 -4.10270  -3.53688  0.570 29.27647  ? 126 VAL A C   1 
ATOM   712  C C   B VAL A 1 127 ? 148.60731 -4.16925  -3.59183  0.430 29.36538  ? 126 VAL A C   1 
ATOM   713  O O   A VAL A 1 127 ? 148.43053 -3.17068  -4.34600  0.570 30.74286  ? 126 VAL A O   1 
ATOM   714  O O   B VAL A 1 127 ? 148.73814 -3.29434  -4.45029  0.430 30.65874  ? 126 VAL A O   1 
ATOM   715  C CB  A VAL A 1 127 ? 148.06480 -3.45980  -1.12755  0.570 33.61238  ? 126 VAL A CB  1 
ATOM   716  C CB  B VAL A 1 127 ? 148.02162 -3.76511  -1.19769  0.430 33.46287  ? 126 VAL A CB  1 
ATOM   717  C CG1 A VAL A 1 127 ? 147.37309 -2.18805  -1.60863  0.570 35.94592  ? 126 VAL A CG1 1 
ATOM   718  C CG1 B VAL A 1 127 ? 148.47406 -4.03576  0.21287   0.430 30.13674  ? 126 VAL A CG1 1 
ATOM   719  C CG2 A VAL A 1 127 ? 147.05269 -4.53842  -0.85802  0.570 28.73742  ? 126 VAL A CG2 1 
ATOM   720  C CG2 B VAL A 1 127 ? 147.49083 -2.34891  -1.35259  0.430 36.30606  ? 126 VAL A CG2 1 
ATOM   721  N N   . GLN A 1 128 ? 147.97066 -5.31376  -3.80197  1.000 28.62929  ? 127 GLN A N   1 
ATOM   722  C CA  . GLN A 1 128 ? 147.16386 -5.58495  -4.98190  1.000 25.92667  ? 127 GLN A CA  1 
ATOM   723  C C   . GLN A 1 128 ? 146.12469 -6.61361  -4.57330  1.000 25.44856  ? 127 GLN A C   1 
ATOM   724  O O   . GLN A 1 128 ? 146.44995 -7.54719  -3.83262  1.000 24.85382  ? 127 GLN A O   1 
ATOM   725  C CB  . GLN A 1 128 ? 147.99429 -6.11662  -6.15769  1.000 26.71757  ? 127 GLN A CB  1 
ATOM   726  C CG  . GLN A 1 128 ? 147.18886 -6.30334  -7.45258  1.000 25.71957  ? 127 GLN A CG  1 
ATOM   727  C CD  . GLN A 1 128 ? 148.04900 -6.76212  -8.60996  1.000 32.61277  ? 127 GLN A CD  1 
ATOM   728  O OE1 . GLN A 1 128 ? 148.92261 -7.60685  -8.43751  1.000 31.69769  ? 127 GLN A OE1 1 
ATOM   729  N NE2 . GLN A 1 128 ? 147.82532 -6.18923  -9.79291  1.000 31.51961  ? 127 GLN A NE2 1 
ATOM   730  N N   . ASP A 1 129 ? 144.87695 -6.43268  -5.01347  1.000 23.73806  ? 128 ASP A N   1 
ATOM   731  C CA  . ASP A 1 129 ? 143.90685 -7.45305  -4.63977  1.000 23.52466  ? 128 ASP A CA  1 
ATOM   732  C C   . ASP A 1 129 ? 144.12347 -8.68918  -5.50967  1.000 23.05071  ? 128 ASP A C   1 
ATOM   733  O O   . ASP A 1 129 ? 144.75470 -8.63940  -6.57251  1.000 22.71122  ? 128 ASP A O   1 
ATOM   734  C CB  . ASP A 1 129 ? 142.45063 -6.93161  -4.70746  1.000 24.51401  ? 128 ASP A CB  1 
ATOM   735  C CG  . ASP A 1 129 ? 141.92803 -6.73023  -6.14158  1.000 29.97785  ? 128 ASP A CG  1 
ATOM   736  O OD1 . ASP A 1 129 ? 141.98843 -7.66302  -6.96375  1.000 26.76793  ? 128 ASP A OD1 1 
ATOM   737  O OD2 . ASP A 1 129 ? 141.40793 -5.63489  -6.43778  1.000 35.48734  ? 128 ASP A OD2 1 
ATOM   738  N N   . LEU A 1 130 ? 143.62862 -9.82301  -5.01909  1.000 22.14023  ? 129 LEU A N   1 
ATOM   739  C CA  . LEU A 1 130 ? 143.93318 -11.07938 -5.68072  1.000 20.17449  ? 129 LEU A CA  1 
ATOM   740  C C   . LEU A 1 130 ? 143.20464 -11.21708 -7.01565  1.000 21.67846  ? 129 LEU A C   1 
ATOM   741  O O   . LEU A 1 130 ? 143.67300 -11.94874 -7.89807  1.000 20.37390  ? 129 LEU A O   1 
ATOM   742  C CB  . LEU A 1 130 ? 143.60143 -12.23951 -4.73297  1.000 18.55427  ? 129 LEU A CB  1 
ATOM   743  C CG  . LEU A 1 130 ? 143.84699 -13.65679 -5.25349  1.000 21.38110  ? 129 LEU A CG  1 
ATOM   744  C CD1 . LEU A 1 130 ? 145.32688 -13.91421 -5.59918  1.000 19.59018  ? 129 LEU A CD1 1 
ATOM   745  C CD2 . LEU A 1 130 ? 143.30551 -14.70042 -4.23785  1.000 20.89355  ? 129 LEU A CD2 1 
ATOM   746  N N   . PHE A 1 131 ? 142.07723 -10.52701 -7.19987  1.000 20.85720  ? 130 PHE A N   1 
ATOM   747  C CA  . PHE A 1 131 ? 141.44230 -10.54016 -8.51541  1.000 21.91847  ? 130 PHE A CA  1 
ATOM   748  C C   . PHE A 1 131 ? 142.37038 -9.93634  -9.56331  1.000 23.17582  ? 130 PHE A C   1 
ATOM   749  O O   . PHE A 1 131 ? 142.60111 -10.53236 -10.62573 1.000 22.49453  ? 130 PHE A O   1 
ATOM   750  C CB  . PHE A 1 131 ? 140.10797 -9.78404  -8.49291  1.000 21.75646  ? 130 PHE A CB  1 
ATOM   751  C CG  . PHE A 1 131 ? 139.42938 -9.77030  -9.83370  1.000 22.90955  ? 130 PHE A CG  1 
ATOM   752  C CD1 . PHE A 1 131 ? 139.72824 -8.78499  -10.77155 1.000 23.87903  ? 130 PHE A CD1 1 
ATOM   753  C CD2 . PHE A 1 131 ? 138.54211 -10.78466 -10.18669 1.000 22.46030  ? 130 PHE A CD2 1 
ATOM   754  C CE1 . PHE A 1 131 ? 139.13394 -8.79617  -12.02595 1.000 28.54676  ? 130 PHE A CE1 1 
ATOM   755  C CE2 . PHE A 1 131 ? 137.93872 -10.79402 -11.46485 1.000 23.58277  ? 130 PHE A CE2 1 
ATOM   756  C CZ  . PHE A 1 131 ? 138.23911 -9.80252  -12.36614 1.000 24.44284  ? 130 PHE A CZ  1 
ATOM   757  N N   . ASP A 1 132 ? 142.90457 -8.74046  -9.28726  1.000 24.40088  ? 131 ASP A N   1 
ATOM   758  C CA  . ASP A 1 132 ? 143.78993 -8.09035  -10.25882 1.000 23.47921  ? 131 ASP A CA  1 
ATOM   759  C C   . ASP A 1 132 ? 145.06282 -8.89607  -10.45836 1.000 24.44148  ? 131 ASP A C   1 
ATOM   760  O O   . ASP A 1 132 ? 145.58285 -8.98829  -11.57280 1.000 25.49956  ? 131 ASP A O   1 
ATOM   761  C CB  . ASP A 1 132 ? 144.14470 -6.67451  -9.80546  1.000 23.33307  ? 131 ASP A CB  1 
ATOM   762  C CG  . ASP A 1 132 ? 142.99014 -5.70029  -9.95008  1.000 32.18033  ? 131 ASP A CG  1 
ATOM   763  O OD1 . ASP A 1 132 ? 142.05739 -5.97120  -10.73502 1.000 31.33485  ? 131 ASP A OD1 1 
ATOM   764  O OD2 . ASP A 1 132 ? 143.03383 -4.64638  -9.28714  1.000 36.73528  ? 131 ASP A OD2 1 
ATOM   765  N N   . PHE A 1 133 ? 145.58268 -9.47465  -9.37927  1.000 22.89882  ? 132 PHE A N   1 
ATOM   766  C CA  . PHE A 1 133 ? 146.78980 -10.28896 -9.46068  1.000 21.70050  ? 132 PHE A CA  1 
ATOM   767  C C   . PHE A 1 133 ? 146.60187 -11.45295 -10.42782 1.000 24.04813  ? 132 PHE A C   1 
ATOM   768  O O   . PHE A 1 133 ? 147.45905 -11.71608 -11.27996 1.000 24.59449  ? 132 PHE A O   1 
ATOM   769  C CB  . PHE A 1 133 ? 147.13670 -10.79407 -8.05379  1.000 20.20679  ? 132 PHE A CB  1 
ATOM   770  C CG  . PHE A 1 133 ? 148.45087 -11.50623 -7.96736  1.000 25.39671  ? 132 PHE A CG  1 
ATOM   771  C CD1 . PHE A 1 133 ? 149.63270 -10.79199 -7.81371  1.000 26.39418  ? 132 PHE A CD1 1 
ATOM   772  C CD2 . PHE A 1 133 ? 148.50417 -12.89329 -8.02630  1.000 23.45073  ? 132 PHE A CD2 1 
ATOM   773  C CE1 . PHE A 1 133 ? 150.85930 -11.44744 -7.72468  1.000 28.25386  ? 132 PHE A CE1 1 
ATOM   774  C CE2 . PHE A 1 133 ? 149.72131 -13.56111 -7.94291  1.000 25.47241  ? 132 PHE A CE2 1 
ATOM   775  C CZ  . PHE A 1 133 ? 150.90654 -12.83059 -7.78599  1.000 27.53687  ? 132 PHE A CZ  1 
ATOM   776  N N   . ILE A 1 134 ? 145.48524 -12.17428 -10.29737 1.000 22.51879  ? 133 ILE A N   1 
ATOM   777  C CA  . ILE A 1 134 ? 145.22933 -13.31964 -11.17421 1.000 21.98235  ? 133 ILE A CA  1 
ATOM   778  C C   . ILE A 1 134 ? 144.94538 -12.85720 -12.60419 1.000 23.15102  ? 133 ILE A C   1 
ATOM   779  O O   . ILE A 1 134 ? 145.36514 -13.50423 -13.57304 1.000 25.16004  ? 133 ILE A O   1 
ATOM   780  C CB  . ILE A 1 134 ? 144.07762 -14.17323 -10.59902 1.000 19.92808  ? 133 ILE A CB  1 
ATOM   781  C CG1 . ILE A 1 134 ? 144.54467 -14.89818 -9.33069  1.000 20.97918  ? 133 ILE A CG1 1 
ATOM   782  C CG2 . ILE A 1 134 ? 143.53629 -15.15895 -11.64980 1.000 20.65098  ? 133 ILE A CG2 1 
ATOM   783  C CD1 . ILE A 1 134 ? 143.36946 -15.51594 -8.50075  1.000 19.55835  ? 133 ILE A CD1 1 
ATOM   784  N N   . THR A 1 135 ? 144.23984 -11.73369 -12.76825 1.000 25.46594  ? 134 THR A N   1 
ATOM   785  C CA  . THR A 1 135 ? 144.05436 -11.18748 -14.11425 1.000 24.55267  ? 134 THR A CA  1 
ATOM   786  C C   . THR A 1 135 ? 145.39359 -10.93409 -14.78936 1.000 28.41798  ? 134 THR A C   1 
ATOM   787  O O   . THR A 1 135 ? 145.58136 -11.27227 -15.96247 1.000 27.74201  ? 134 THR A O   1 
ATOM   788  C CB  . THR A 1 135 ? 143.24395 -9.89216  -14.06634 1.000 25.89705  ? 134 THR A CB  1 
ATOM   789  O OG1 . THR A 1 135 ? 141.93129 -10.16531 -13.56610 1.000 25.44304  ? 134 THR A OG1 1 
ATOM   790  C CG2 . THR A 1 135 ? 143.13590 -9.26155  -15.46734 1.000 31.57498  ? 134 THR A CG2 1 
ATOM   791  N N   . GLU A 1 136 ? 146.35063 -10.36732 -14.05856 1.000 25.03758  ? 135 GLU A N   1 
ATOM   792  C CA  . GLU A 1 136 ? 147.61449 -9.99819  -14.68921 1.000 30.20681  ? 135 GLU A CA  1 
ATOM   793  C C   . GLU A 1 136 ? 148.54807 -11.19247 -14.84875 1.000 34.15888  ? 135 GLU A C   1 
ATOM   794  O O   . GLU A 1 136 ? 149.25986 -11.29168 -15.85454 1.000 29.69443  ? 135 GLU A O   1 
ATOM   795  C CB  . GLU A 1 136 ? 148.29529 -8.89023  -13.88517 1.000 28.44765  ? 135 GLU A CB  1 
ATOM   796  C CG  . GLU A 1 136 ? 147.44806 -7.62931  -13.81552 1.000 40.24160  ? 135 GLU A CG  1 
ATOM   797  C CD  . GLU A 1 136 ? 148.12860 -6.49411  -13.07682 1.000 48.22440  ? 135 GLU A CD  1 
ATOM   798  O OE1 . GLU A 1 136 ? 149.25229 -6.70316  -12.56289 1.000 45.71332  ? 135 GLU A OE1 1 
ATOM   799  O OE2 . GLU A 1 136 ? 147.52844 -5.39781  -13.00893 1.000 52.28253  ? 135 GLU A OE2 1 
ATOM   800  N N   . ARG A 1 137 ? 148.54949 -12.11493 -13.88905 1.000 30.76658  ? 136 ARG A N   1 
ATOM   801  C CA  . ARG A 1 137 ? 149.49494 -13.22295 -13.91995 1.000 30.28369  ? 136 ARG A CA  1 
ATOM   802  C C   . ARG A 1 137 ? 148.95463 -14.46202 -14.61615 1.000 30.27057  ? 136 ARG A C   1 
ATOM   803  O O   . ARG A 1 137 ? 149.75017 -15.31671 -15.02331 1.000 31.85563  ? 136 ARG A O   1 
ATOM   804  C CB  . ARG A 1 137 ? 149.92480 -13.59224 -12.48979 1.000 30.73339  ? 136 ARG A CB  1 
ATOM   805  C CG  . ARG A 1 137 ? 150.44910 -12.41509 -11.66081 1.000 44.03713  ? 136 ARG A CG  1 
ATOM   806  C CD  . ARG A 1 137 ? 151.93953 -12.19463 -11.84377 1.000 49.94805  ? 136 ARG A CD  1 
ATOM   807  N NE  . ARG A 1 137 ? 152.70591 -13.26955 -11.22497 1.000 56.35151  ? 136 ARG A NE  1 
ATOM   808  C CZ  . ARG A 1 137 ? 153.51047 -13.12307 -10.18014 1.000 41.68473  ? 136 ARG A CZ  1 
ATOM   809  N NH1 . ARG A 1 137 ? 153.73113 -11.93520 -9.63468  1.000 39.16640  ? 136 ARG A NH1 1 
ATOM   810  N NH2 . ARG A 1 137 ? 154.12293 -14.19347 -9.68264  1.000 39.12246  ? 136 ARG A NH2 1 
ATOM   811  N N   . GLY A 1 138 ? 147.63572 -14.57838 -14.77771 1.000 26.72721  ? 137 GLY A N   1 
ATOM   812  C CA  . GLY A 1 138 ? 147.04711 -15.81333 -15.25863 1.000 27.81684  ? 137 GLY A CA  1 
ATOM   813  C C   . GLY A 1 138 ? 146.96008 -16.84653 -14.14326 1.000 25.02816  ? 137 GLY A C   1 
ATOM   814  O O   . GLY A 1 138 ? 147.14021 -16.53989 -12.95799 1.000 26.95824  ? 137 GLY A O   1 
ATOM   815  N N   . ALA A 1 139 ? 146.69019 -18.09671 -14.54304 1.000 24.38544  ? 138 ALA A N   1 
ATOM   816  C CA  . ALA A 1 139 ? 146.68022 -19.22557 -13.60738 1.000 22.21103  ? 138 ALA A CA  1 
ATOM   817  C C   . ALA A 1 139 ? 147.97828 -19.26735 -12.81099 1.000 26.68767  ? 138 ALA A C   1 
ATOM   818  O O   . ALA A 1 139 ? 149.06679 -19.13447 -13.37351 1.000 23.87097  ? 138 ALA A O   1 
ATOM   819  C CB  . ALA A 1 139 ? 146.50192 -20.54157 -14.38021 1.000 24.98765  ? 138 ALA A CB  1 
ATOM   820  N N   . LEU A 1 140 ? 147.86074 -19.44338 -11.49892 1.000 19.91891  ? 139 LEU A N   1 
ATOM   821  C CA  . LEU A 1 140 ? 149.01113 -19.39050 -10.60687 1.000 22.75765  ? 139 LEU A CA  1 
ATOM   822  C C   . LEU A 1 140 ? 149.68350 -20.75514 -10.51986 1.000 24.12920  ? 139 LEU A C   1 
ATOM   823  O O   . LEU A 1 140 ? 149.00985 -21.78741 -10.47339 1.000 21.65545  ? 139 LEU A O   1 
ATOM   824  C CB  . LEU A 1 140 ? 148.57458 -18.93928 -9.20824  1.000 17.58001  ? 139 LEU A CB  1 
ATOM   825  C CG  . LEU A 1 140 ? 147.84226 -17.58822 -9.11974  1.000 21.43369  ? 139 LEU A CG  1 
ATOM   826  C CD1 . LEU A 1 140 ? 147.55866 -17.24013 -7.65031  1.000 22.38922  ? 139 LEU A CD1 1 
ATOM   827  C CD2 . LEU A 1 140 ? 148.64743 -16.46167 -9.84045  1.000 22.34334  ? 139 LEU A CD2 1 
ATOM   828  N N   . GLN A 1 141 ? 151.01773 -20.75340 -10.48142 1.000 25.23248  ? 140 GLN A N   1 
ATOM   829  C CA  . GLN A 1 141 ? 151.75005 -21.96319 -10.11866 1.000 25.89115  ? 140 GLN A CA  1 
ATOM   830  C C   . GLN A 1 141 ? 151.17293 -22.56092 -8.83907  1.000 23.00980  ? 140 GLN A C   1 
ATOM   831  O O   . GLN A 1 141 ? 150.77027 -21.83373 -7.92456  1.000 20.75735  ? 140 GLN A O   1 
ATOM   832  C CB  . GLN A 1 141 ? 153.23349 -21.64867 -9.92355  1.000 25.10655  ? 140 GLN A CB  1 
ATOM   833  C CG  . GLN A 1 141 ? 153.92331 -21.15780 -11.18876 1.000 33.38056  ? 140 GLN A CG  1 
ATOM   834  C CD  . GLN A 1 141 ? 155.39594 -20.86340 -10.96985 1.000 37.48122  ? 140 GLN A CD  1 
ATOM   835  O OE1 . GLN A 1 141 ? 155.95938 -21.19444 -9.92551  1.000 39.08128  ? 140 GLN A OE1 1 
ATOM   836  N NE2 . GLN A 1 141 ? 156.02357 -20.22790 -11.95324 1.000 50.35836  ? 140 GLN A NE2 1 
ATOM   837  N N   . GLU A 1 142 ? 151.10901 -23.89737 -8.78258  1.000 23.33345  ? 141 GLU A N   1 
ATOM   838  C CA  . GLU A 1 142 ? 150.45837 -24.53031 -7.63205  1.000 20.51405  ? 141 GLU A CA  1 
ATOM   839  C C   . GLU A 1 142 ? 151.16877 -24.20471 -6.32288  1.000 23.17166  ? 141 GLU A C   1 
ATOM   840  O O   . GLU A 1 142 ? 150.52301 -24.12883 -5.27502  1.000 23.45581  ? 141 GLU A O   1 
ATOM   841  C CB  . GLU A 1 142 ? 150.36252 -26.04087 -7.83625  1.000 21.05607  ? 141 GLU A CB  1 
ATOM   842  C CG  . GLU A 1 142 ? 149.29561 -26.37414 -8.90394  1.000 23.33356  ? 141 GLU A CG  1 
ATOM   843  C CD  . GLU A 1 142 ? 148.97535 -27.85199 -9.03980  1.000 25.98433  ? 141 GLU A CD  1 
ATOM   844  O OE1 . GLU A 1 142 ? 149.12721 -28.61598 -8.05814  1.000 23.45537  ? 141 GLU A OE1 1 
ATOM   845  O OE2 . GLU A 1 142 ? 148.56122 -28.25466 -10.15450 1.000 28.10060  ? 141 GLU A OE2 1 
ATOM   846  N N   . GLU A 1 143 ? 152.49083 -24.01511 -6.35549  1.000 22.71424  ? 142 GLU A N   1 
ATOM   847  C CA  . GLU A 1 143 ? 153.19674 -23.62459 -5.13828  1.000 22.44900  ? 142 GLU A CA  1 
ATOM   848  C C   . GLU A 1 143 ? 152.69599 -22.28288 -4.61282  1.000 23.20647  ? 142 GLU A C   1 
ATOM   849  O O   . GLU A 1 143 ? 152.55125 -22.08754 -3.39546  1.000 22.51018  ? 142 GLU A O   1 
ATOM   850  C CB  . GLU A 1 143 ? 154.69548 -23.55931 -5.41216  1.000 26.90339  ? 142 GLU A CB  1 
ATOM   851  C CG  . GLU A 1 143 ? 155.50939 -23.05342 -4.25947  1.000 26.88571  ? 142 GLU A CG  1 
ATOM   852  C CD  . GLU A 1 143 ? 156.96926 -22.96771 -4.61599  1.000 32.66934  ? 142 GLU A CD  1 
ATOM   853  O OE1 . GLU A 1 143 ? 157.38341 -21.94998 -5.21681  1.000 28.05739  ? 142 GLU A OE1 1 
ATOM   854  O OE2 . GLU A 1 143 ? 157.68478 -23.93910 -4.31085  1.000 35.31059  ? 142 GLU A OE2 1 
ATOM   855  N N   . LEU A 1 144 ? 152.43364 -21.34373 -5.51542  1.000 22.06721  ? 143 LEU A N   1 
ATOM   856  C CA  . LEU A 1 144 ? 151.92759 -20.04047 -5.10500  1.000 19.26543  ? 143 LEU A CA  1 
ATOM   857  C C   . LEU A 1 144 ? 150.46722 -20.12809 -4.67977  1.000 22.53286  ? 143 LEU A C   1 
ATOM   858  O O   . LEU A 1 144 ? 150.06493 -19.52337 -3.67495  1.000 21.72055  ? 143 LEU A O   1 
ATOM   859  C CB  . LEU A 1 144 ? 152.10451 -19.04418 -6.25043  1.000 18.94982  ? 143 LEU A CB  1 
ATOM   860  C CG  . LEU A 1 144 ? 151.58791 -17.62782 -6.02674  1.000 25.36359  ? 143 LEU A CG  1 
ATOM   861  C CD1 . LEU A 1 144 ? 152.27830 -17.00515 -4.80046  1.000 22.76355  ? 143 LEU A CD1 1 
ATOM   862  C CD2 . LEU A 1 144 ? 151.83820 -16.80208 -7.29753  1.000 23.44072  ? 143 LEU A CD2 1 
ATOM   863  N N   . ALA A 1 145 ? 149.66098 -20.88418 -5.42623  1.000 20.70069  ? 144 ALA A N   1 
ATOM   864  C CA  . ALA A 1 145 ? 148.27186 -21.07896 -5.03392  1.000 20.09791  ? 144 ALA A CA  1 
ATOM   865  C C   . ALA A 1 145 ? 148.18398 -21.75356 -3.67359  1.000 19.47040  ? 144 ALA A C   1 
ATOM   866  O O   . ALA A 1 145 ? 147.30073 -21.43261 -2.87323  1.000 20.02560  ? 144 ALA A O   1 
ATOM   867  C CB  . ALA A 1 145 ? 147.54152 -21.91427 -6.08568  1.000 19.03575  ? 144 ALA A CB  1 
ATOM   868  N N   . ARG A 1 146 ? 149.07473 -22.71977 -3.41259  1.000 19.56037  ? 145 ARG A N   1 
ATOM   869  C CA  . ARG A 1 146 ? 149.08386 -23.39605 -2.11425  1.000 19.25866  ? 145 ARG A CA  1 
ATOM   870  C C   . ARG A 1 146 ? 149.35820 -22.41248 -0.98416  1.000 20.74720  ? 145 ARG A C   1 
ATOM   871  O O   . ARG A 1 146 ? 148.69245 -22.44902 0.06057   1.000 19.18808  ? 145 ARG A O   1 
ATOM   872  C CB  . ARG A 1 146 ? 150.13117 -24.51758 -2.11053  1.000 19.76414  ? 145 ARG A CB  1 
ATOM   873  C CG  . ARG A 1 146 ? 150.34041 -25.17006 -0.72915  1.000 21.27109  ? 145 ARG A CG  1 
ATOM   874  C CD  . ARG A 1 146 ? 151.46744 -26.22546 -0.75561  1.000 21.91605  ? 145 ARG A CD  1 
ATOM   875  N NE  . ARG A 1 146 ? 151.15541 -27.24084 -1.75714  1.000 25.65620  ? 145 ARG A NE  1 
ATOM   876  C CZ  . ARG A 1 146 ? 151.81424 -27.42361 -2.89408  1.000 28.96988  ? 145 ARG A CZ  1 
ATOM   877  N NH1 . ARG A 1 146 ? 152.93545 -26.76323 -3.16583  1.000 25.83602  ? 145 ARG A NH1 1 
ATOM   878  N NH2 . ARG A 1 146 ? 151.33348 -28.28641 -3.78553  1.000 24.46297  ? 145 ARG A NH2 1 
ATOM   879  N N   . SER A 1 147 ? 150.33283 -21.51941 -1.17744  1.000 21.02518  ? 146 SER A N   1 
ATOM   880  C CA  . SER A 1 147 ? 150.67342 -20.55394 -0.13787  1.000 22.24055  ? 146 SER A CA  1 
ATOM   881  C C   . SER A 1 147 ? 149.52356 -19.58668 0.09994   1.000 21.54119  ? 146 SER A C   1 
ATOM   882  O O   . SER A 1 147 ? 149.12737 -19.34769 1.24387   1.000 19.56112  ? 146 SER A O   1 
ATOM   883  C CB  . SER A 1 147 ? 151.94328 -19.79615 -0.52880  1.000 22.26208  ? 146 SER A CB  1 
ATOM   884  O OG  . SER A 1 147 ? 152.17809 -18.71846 0.36453   1.000 21.98911  ? 146 SER A OG  1 
ATOM   885  N N   . PHE A 1 148 ? 148.96279 -19.03356 -0.98168  1.000 17.54180  ? 147 PHE A N   1 
ATOM   886  C CA  . PHE A 1 148 ? 147.81377 -18.14123 -0.86503  1.000 19.83512  ? 147 PHE A CA  1 
ATOM   887  C C   . PHE A 1 148 ? 146.62603 -18.84375 -0.21726  1.000 22.69540  ? 147 PHE A C   1 
ATOM   888  O O   . PHE A 1 148 ? 146.01362 -18.31979 0.72261   1.000 19.02095  ? 147 PHE A O   1 
ATOM   889  C CB  . PHE A 1 148 ? 147.41754 -17.61529 -2.24324  1.000 17.24234  ? 147 PHE A CB  1 
ATOM   890  C CG  . PHE A 1 148 ? 148.31062 -16.53095 -2.76827  1.000 21.34841  ? 147 PHE A CG  1 
ATOM   891  C CD1 . PHE A 1 148 ? 149.43679 -16.13080 -2.07082  1.000 22.76340  ? 147 PHE A CD1 1 
ATOM   892  C CD2 . PHE A 1 148 ? 148.00614 -15.89916 -3.97084  1.000 22.55523  ? 147 PHE A CD2 1 
ATOM   893  C CE1 . PHE A 1 148 ? 150.24659 -15.11105 -2.56909  1.000 27.52000  ? 147 PHE A CE1 1 
ATOM   894  C CE2 . PHE A 1 148 ? 148.80289 -14.88624 -4.47090  1.000 24.34498  ? 147 PHE A CE2 1 
ATOM   895  C CZ  . PHE A 1 148 ? 149.92420 -14.48943 -3.77426  1.000 25.11116  ? 147 PHE A CZ  1 
ATOM   896  N N   . PHE A 1 149 ? 146.27732 -20.02825 -0.72026  1.000 18.01699  ? 148 PHE A N   1 
ATOM   897  C CA  . PHE A 1 149 ? 145.10866 -20.73434 -0.20453  1.000 19.30028  ? 148 PHE A CA  1 
ATOM   898  C C   . PHE A 1 149 ? 145.27298 -21.07230 1.27126   1.000 20.00088  ? 148 PHE A C   1 
ATOM   899  O O   . PHE A 1 149 ? 144.33021 -20.91535 2.05611   1.000 19.95823  ? 148 PHE A O   1 
ATOM   900  C CB  . PHE A 1 149 ? 144.86436 -22.00294 -1.02366  1.000 19.83208  ? 148 PHE A CB  1 
ATOM   901  C CG  . PHE A 1 149 ? 143.49182 -22.61635 -0.81910  1.000 17.19665  ? 148 PHE A CG  1 
ATOM   902  C CD1 . PHE A 1 149 ? 142.34908 -21.88337 -1.09045  1.000 19.54398  ? 148 PHE A CD1 1 
ATOM   903  C CD2 . PHE A 1 149 ? 143.35778 -23.93722 -0.42408  1.000 17.69763  ? 148 PHE A CD2 1 
ATOM   904  C CE1 . PHE A 1 149 ? 141.09661 -22.43750 -0.93669  1.000 18.67616  ? 148 PHE A CE1 1 
ATOM   905  C CE2 . PHE A 1 149 ? 142.10324 -24.50416 -0.27747  1.000 19.69948  ? 148 PHE A CE2 1 
ATOM   906  C CZ  . PHE A 1 149 ? 140.97576 -23.75574 -0.52722  1.000 17.77673  ? 148 PHE A CZ  1 
ATOM   907  N N   . TRP A 1 150 ? 146.46311 -21.53743 1.66366   1.000 18.35754  ? 149 TRP A N   1 
ATOM   908  C CA  . TRP A 1 150 ? 146.75617 -21.79530 3.07307   1.000 18.58482  ? 149 TRP A CA  1 
ATOM   909  C C   . TRP A 1 150 ? 146.47827 -20.57152 3.94131   1.000 18.33478  ? 149 TRP A C   1 
ATOM   910  O O   . TRP A 1 150 ? 145.82241 -20.67103 4.98682   1.000 18.50548  ? 149 TRP A O   1 
ATOM   911  C CB  . TRP A 1 150 ? 148.21862 -22.22635 3.22194   1.000 18.49450  ? 149 TRP A CB  1 
ATOM   912  C CG  . TRP A 1 150 ? 148.59707 -22.60398 4.61897   1.000 19.34127  ? 149 TRP A CG  1 
ATOM   913  C CD1 . TRP A 1 150 ? 149.11946 -21.78289 5.59460   1.000 20.61041  ? 149 TRP A CD1 1 
ATOM   914  C CD2 . TRP A 1 150 ? 148.46063 -23.89565 5.21148   1.000 19.74849  ? 149 TRP A CD2 1 
ATOM   915  N NE1 . TRP A 1 150 ? 149.31465 -22.50278 6.75511   1.000 23.06711  ? 149 TRP A NE1 1 
ATOM   916  C CE2 . TRP A 1 150 ? 148.93639 -23.80316 6.53957   1.000 22.45034  ? 149 TRP A CE2 1 
ATOM   917  C CE3 . TRP A 1 150 ? 148.00731 -25.13169 4.74189   1.000 21.56126  ? 149 TRP A CE3 1 
ATOM   918  C CZ2 . TRP A 1 150 ? 148.94854 -24.89582 7.40574   1.000 23.21412  ? 149 TRP A CZ2 1 
ATOM   919  C CZ3 . TRP A 1 150 ? 148.02004 -26.22892 5.61144   1.000 21.28665  ? 149 TRP A CZ3 1 
ATOM   920  C CH2 . TRP A 1 150 ? 148.49373 -26.09628 6.92639   1.000 24.08646  ? 149 TRP A CH2 1 
ATOM   921  N N   . GLN A 1 151 ? 146.98502 -19.40493 3.53345   1.000 18.32120  ? 150 GLN A N   1 
ATOM   922  C CA  . GLN A 1 151 ? 146.78293 -18.20384 4.33856   1.000 19.13124  ? 150 GLN A CA  1 
ATOM   923  C C   . GLN A 1 151 ? 145.31393 -17.82333 4.40818   1.000 19.96013  ? 150 GLN A C   1 
ATOM   924  O O   . GLN A 1 151 ? 144.84981 -17.32791 5.44108   1.000 18.89188  ? 150 GLN A O   1 
ATOM   925  C CB  . GLN A 1 151 ? 147.59109 -17.03936 3.77622   1.000 20.39438  ? 150 GLN A CB  1 
ATOM   926  C CG  . GLN A 1 151 ? 149.07876 -17.16014 4.04640   1.000 22.96610  ? 150 GLN A CG  1 
ATOM   927  C CD  . GLN A 1 151 ? 149.82063 -15.91513 3.64521   1.000 27.47138  ? 150 GLN A CD  1 
ATOM   928  O OE1 . GLN A 1 151 ? 149.38211 -14.80783 3.93282   1.000 24.64452  ? 150 GLN A OE1 1 
ATOM   929  N NE2 . GLN A 1 151 ? 150.95119 -16.08880 2.96513   1.000 26.47674  ? 150 GLN A NE2 1 
ATOM   930  N N   . VAL A 1 152 ? 144.57307 -18.01709 3.31002   1.000 18.69836  ? 151 VAL A N   1 
ATOM   931  C CA  . VAL A 1 152 ? 143.13675 -17.74162 3.34375   1.000 19.06491  ? 151 VAL A CA  1 
ATOM   932  C C   . VAL A 1 152 ? 142.44099 -18.67437 4.32710   1.000 18.80097  ? 151 VAL A C   1 
ATOM   933  O O   . VAL A 1 152 ? 141.57379 -18.24947 5.10101   1.000 20.12177  ? 151 VAL A O   1 
ATOM   934  C CB  . VAL A 1 152 ? 142.52529 -17.84052 1.92948   1.000 18.92288  ? 151 VAL A CB  1 
ATOM   935  C CG1 . VAL A 1 152 ? 140.99984 -17.73068 2.00303   1.000 20.27860  ? 151 VAL A CG1 1 
ATOM   936  C CG2 . VAL A 1 152 ? 143.09897 -16.74014 0.99884   1.000 19.36817  ? 151 VAL A CG2 1 
ATOM   937  N N   A LEU A 1 153 ? 142.81512 -19.95281 4.33817   0.437 17.87672  ? 152 LEU A N   1 
ATOM   938  N N   B LEU A 1 153 ? 142.79990 -19.96323 4.30618   0.563 17.83234  ? 152 LEU A N   1 
ATOM   939  C CA  A LEU A 1 153 ? 142.19810 -20.85933 5.30366   0.437 19.56887  ? 152 LEU A CA  1 
ATOM   940  C CA  B LEU A 1 153 ? 142.24603 -20.89916 5.28518   0.563 19.60475  ? 152 LEU A CA  1 
ATOM   941  C C   A LEU A 1 153 ? 142.52105 -20.46002 6.73750   0.437 20.62257  ? 152 LEU A C   1 
ATOM   942  C C   B LEU A 1 153 ? 142.51671 -20.43167 6.71117   0.563 20.63255  ? 152 LEU A C   1 
ATOM   943  O O   A LEU A 1 153 ? 141.66112 -20.54931 7.62278   0.437 18.87251  ? 152 LEU A O   1 
ATOM   944  O O   B LEU A 1 153 ? 141.61918 -20.43864 7.56259   0.563 18.88243  ? 152 LEU A O   1 
ATOM   945  C CB  A LEU A 1 153 ? 142.64298 -22.28848 5.03447   0.437 19.96742  ? 152 LEU A CB  1 
ATOM   946  C CB  B LEU A 1 153 ? 142.82346 -22.30156 5.06312   0.563 19.86495  ? 152 LEU A CB  1 
ATOM   947  C CG  A LEU A 1 153 ? 142.06646 -22.76424 3.70562   0.437 19.55508  ? 152 LEU A CG  1 
ATOM   948  C CG  B LEU A 1 153 ? 142.03202 -23.29127 4.18674   0.563 19.71850  ? 152 LEU A CG  1 
ATOM   949  C CD1 A LEU A 1 153 ? 142.99801 -23.75697 3.13112   0.437 19.49604  ? 152 LEU A CD1 1 
ATOM   950  C CD1 B LEU A 1 153 ? 140.95204 -24.02121 4.99147   0.563 20.43020  ? 152 LEU A CD1 1 
ATOM   951  C CD2 A LEU A 1 153 ? 140.68412 -23.37342 3.88670   0.437 19.47768  ? 152 LEU A CD2 1 
ATOM   952  C CD2 B LEU A 1 153 ? 141.40827 -22.58760 2.98697   0.563 18.02412  ? 152 LEU A CD2 1 
ATOM   953  N N   . GLU A 1 154 ? 143.75524 -20.03010 6.99956   1.000 18.09593  ? 153 GLU A N   1 
ATOM   954  C CA  . GLU A 1 154 ? 144.07454 -19.59083 8.36229   1.000 19.25829  ? 153 GLU A CA  1 
ATOM   955  C C   . GLU A 1 154 ? 143.25465 -18.36295 8.74614   1.000 21.86567  ? 153 GLU A C   1 
ATOM   956  O O   . GLU A 1 154 ? 142.79305 -18.24033 9.88934   1.000 19.30493  ? 153 GLU A O   1 
ATOM   957  C CB  . GLU A 1 154 ? 145.57459 -19.31504 8.49556   1.000 19.49818  ? 153 GLU A CB  1 
ATOM   958  C CG  . GLU A 1 154 ? 146.43517 -20.59001 8.39022   1.000 19.96763  ? 153 GLU A CG  1 
ATOM   959  C CD  . GLU A 1 154 ? 146.39972 -21.42431 9.66955   1.000 24.23024  ? 153 GLU A CD  1 
ATOM   960  O OE1 . GLU A 1 154 ? 146.33814 -20.83178 10.75841  1.000 29.08678  ? 153 GLU A OE1 1 
ATOM   961  O OE2 . GLU A 1 154 ? 146.42247 -22.66429 9.58319   1.000 22.79280  ? 153 GLU A OE2 1 
ATOM   962  N N   . ALA A 1 155 ? 143.04325 -17.45159 7.79535   1.000 17.83140  ? 154 ALA A N   1 
ATOM   963  C CA  . ALA A 1 155 ? 142.26000 -16.24947 8.07411   1.000 21.75168  ? 154 ALA A CA  1 
ATOM   964  C C   . ALA A 1 155 ? 140.79129 -16.58517 8.30758   1.000 21.75200  ? 154 ALA A C   1 
ATOM   965  O O   . ALA A 1 155 ? 140.15070 -16.02758 9.20822   1.000 20.05400  ? 154 ALA A O   1 
ATOM   966  C CB  . ALA A 1 155 ? 142.40014 -15.25125 6.92120   1.000 21.92586  ? 154 ALA A CB  1 
ATOM   967  N N   . VAL A 1 156 ? 140.23930 -17.48808 7.50162   1.000 18.68173  ? 155 VAL A N   1 
ATOM   968  C CA  . VAL A 1 156 ? 138.84354 -17.87694 7.67604   1.000 17.90172  ? 155 VAL A CA  1 
ATOM   969  C C   . VAL A 1 156 ? 138.66725 -18.64323 8.98012   1.000 20.94730  ? 155 VAL A C   1 
ATOM   970  O O   . VAL A 1 156 ? 137.67082 -18.46121 9.69474   1.000 20.74773  ? 155 VAL A O   1 
ATOM   971  C CB  . VAL A 1 156 ? 138.37563 -18.69120 6.45373   1.000 22.58757  ? 155 VAL A CB  1 
ATOM   972  C CG1 . VAL A 1 156 ? 137.01852 -19.32992 6.70733   1.000 22.23493  ? 155 VAL A CG1 1 
ATOM   973  C CG2 . VAL A 1 156 ? 138.33469 -17.79144 5.20463   1.000 22.26806  ? 155 VAL A CG2 1 
ATOM   974  N N   . ARG A 1 157 ? 139.63003 -19.50376 9.32689   1.000 18.84375  ? 156 ARG A N   1 
ATOM   975  C CA  . ARG A 1 157 ? 139.59014 -20.13322 10.65182  1.000 20.53897  ? 156 ARG A CA  1 
ATOM   976  C C   . ARG A 1 157 ? 139.57121 -19.09228 11.76226  1.000 23.73807  ? 156 ARG A C   1 
ATOM   977  O O   . ARG A 1 157 ? 138.84368 -19.23658 12.75419  1.000 22.19425  ? 156 ARG A O   1 
ATOM   978  C CB  . ARG A 1 157 ? 140.79164 -21.06503 10.83511  1.000 24.12405  ? 156 ARG A CB  1 
ATOM   979  C CG  . ARG A 1 157 ? 140.68331 -22.37758 10.09216  1.000 22.65309  ? 156 ARG A CG  1 
ATOM   980  C CD  . ARG A 1 157 ? 141.91959 -23.23485 10.33592  1.000 23.82220  ? 156 ARG A CD  1 
ATOM   981  N NE  . ARG A 1 157 ? 142.06183 -23.56913 11.75009  1.000 21.18206  ? 156 ARG A NE  1 
ATOM   982  C CZ  . ARG A 1 157 ? 143.17630 -24.03703 12.29591  1.000 23.12004  ? 156 ARG A CZ  1 
ATOM   983  N NH1 . ARG A 1 157 ? 144.27083 -24.23265 11.57313  1.000 21.26706  ? 156 ARG A NH1 1 
ATOM   984  N NH2 . ARG A 1 157 ? 143.19722 -24.30110 13.59792  1.000 22.90110  ? 156 ARG A NH2 1 
ATOM   985  N N   . HIS A 1 158 ? 140.39412 -18.05190 11.63469  1.000 21.04803  ? 157 HIS A N   1 
ATOM   986  C CA  . HIS A 1 158 ? 140.42150 -17.00044 12.64822  1.000 22.94054  ? 157 HIS A CA  1 
ATOM   987  C C   . HIS A 1 158 ? 139.05486 -16.34399 12.78415  1.000 24.04156  ? 157 HIS A C   1 
ATOM   988  O O   . HIS A 1 158 ? 138.54583 -16.15347 13.89827  1.000 23.17118  ? 157 HIS A O   1 
ATOM   989  C CB  . HIS A 1 158 ? 141.48211 -15.96190 12.27666  1.000 21.28509  ? 157 HIS A CB  1 
ATOM   990  C CG  . HIS A 1 158 ? 141.42150 -14.71821 13.10640  1.000 27.75865  ? 157 HIS A CG  1 
ATOM   991  N ND1 . HIS A 1 158 ? 141.92262 -14.65499 14.39060  1.000 24.00656  ? 157 HIS A ND1 1 
ATOM   992  C CD2 . HIS A 1 158 ? 140.91858 -13.48934 12.83377  1.000 29.53519  ? 157 HIS A CD2 1 
ATOM   993  C CE1 . HIS A 1 158 ? 141.72392 -13.43897 14.87624  1.000 29.96624  ? 157 HIS A CE1 1 
ATOM   994  N NE2 . HIS A 1 158 ? 141.11648 -12.71199 13.95103  1.000 26.91955  ? 157 HIS A NE2 1 
ATOM   995  N N   . CYS A 1 159 ? 138.44027 -15.99376 11.64908  1.000 22.27401  ? 158 CYS A N   1 
ATOM   996  C CA  . CYS A 1 159 ? 137.10082 -15.40917 11.68349  1.000 22.08189  ? 158 CYS A CA  1 
ATOM   997  C C   . CYS A 1 159 ? 136.11786 -16.32258 12.40276  1.000 21.05389  ? 158 CYS A C   1 
ATOM   998  O O   . CYS A 1 159 ? 135.38937 -15.88945 13.30410  1.000 22.37249  ? 158 CYS A O   1 
ATOM   999  C CB  . CYS A 1 159 ? 136.61981 -15.13352 10.26296  1.000 20.91208  ? 158 CYS A CB  1 
ATOM   1000 S SG  . CYS A 1 159 ? 137.57741 -13.82518 9.44612   1.000 24.56931  ? 158 CYS A SG  1 
ATOM   1001 N N   . HIS A 1 160 ? 136.06671 -17.59732 12.00145  1.000 19.40051  ? 159 HIS A N   1 
ATOM   1002 C CA  . HIS A 1 160 ? 135.11709 -18.50735 12.62726  1.000 21.02267  ? 159 HIS A CA  1 
ATOM   1003 C C   . HIS A 1 160 ? 135.40923 -18.67959 14.11632  1.000 24.25277  ? 159 HIS A C   1 
ATOM   1004 O O   . HIS A 1 160 ? 134.48099 -18.75573 14.92595  1.000 23.69869  ? 159 HIS A O   1 
ATOM   1005 C CB  . HIS A 1 160 ? 135.12729 -19.85250 11.90465  1.000 22.11234  ? 159 HIS A CB  1 
ATOM   1006 C CG  . HIS A 1 160 ? 134.58953 -19.77543 10.50639  1.000 27.77865  ? 159 HIS A CG  1 
ATOM   1007 N ND1 . HIS A 1 160 ? 134.05230 -20.86126 9.85021   1.000 41.00814  ? 159 HIS A ND1 1 
ATOM   1008 C CD2 . HIS A 1 160 ? 134.49240 -18.73170 9.64406   1.000 33.88903  ? 159 HIS A CD2 1 
ATOM   1009 C CE1 . HIS A 1 160 ? 133.65213 -20.49236 8.64404   1.000 34.28369  ? 159 HIS A CE1 1 
ATOM   1010 N NE2 . HIS A 1 160 ? 133.90834 -19.20583 8.49523   1.000 30.10405  ? 159 HIS A NE2 1 
ATOM   1011 N N   . ASN A 1 161 ? 136.68873 -18.74022 14.49833  1.000 23.01993  ? 160 ASN A N   1 
ATOM   1012 C CA  . ASN A 1 161 ? 137.03015 -18.80925 15.92290  1.000 26.57830  ? 160 ASN A CA  1 
ATOM   1013 C C   . ASN A 1 161 ? 136.52983 -17.59201 16.69139  1.000 29.91000  ? 160 ASN A C   1 
ATOM   1014 O O   . ASN A 1 161 ? 136.22509 -17.69261 17.89086  1.000 26.05446  ? 160 ASN A O   1 
ATOM   1015 C CB  . ASN A 1 161 ? 138.54086 -18.93463 16.10909  1.000 30.77679  ? 160 ASN A CB  1 
ATOM   1016 C CG  . ASN A 1 161 ? 139.08235 -20.27574 15.64176  1.000 38.05631  ? 160 ASN A CG  1 
ATOM   1017 O OD1 . ASN A 1 161 ? 138.33605 -21.24804 15.48664  1.000 46.21040  ? 160 ASN A OD1 1 
ATOM   1018 N ND2 . ASN A 1 161 ? 140.39187 -20.33460 15.42615  1.000 44.45333  ? 160 ASN A ND2 1 
ATOM   1019 N N   . CYS A 1 162 ? 136.47404 -16.43573 16.03736  1.000 23.43840  ? 161 CYS A N   1 
ATOM   1020 C CA  . CYS A 1 162 ? 135.97503 -15.20203 16.63192  1.000 27.72505  ? 161 CYS A CA  1 
ATOM   1021 C C   . CYS A 1 162 ? 134.45946 -15.05878 16.50674  1.000 29.54036  ? 161 CYS A C   1 
ATOM   1022 O O   . CYS A 1 162 ? 133.91708 -14.01725 16.88270  1.000 26.85748  ? 161 CYS A O   1 
ATOM   1023 C CB  . CYS A 1 162 ? 136.66713 -13.99040 15.98758  1.000 28.21460  ? 161 CYS A CB  1 
ATOM   1024 S SG  . CYS A 1 162 ? 138.45860 -13.88882 16.29553  1.000 32.28042  ? 161 CYS A SG  1 
ATOM   1025 N N   . GLY A 1 163 ? 133.77090 -16.07506 15.99053  1.000 25.08554  ? 162 GLY A N   1 
ATOM   1026 C CA  . GLY A 1 163 ? 132.32546 -16.03314 15.87239  1.000 26.71024  ? 162 GLY A CA  1 
ATOM   1027 C C   . GLY A 1 163 ? 131.80047 -15.29754 14.66221  1.000 24.88032  ? 162 GLY A C   1 
ATOM   1028 O O   . GLY A 1 163 ? 130.64854 -14.84301 14.68999  1.000 23.70180  ? 162 GLY A O   1 
ATOM   1029 N N   . VAL A 1 164 ? 132.60040 -15.18136 13.59171  1.000 22.63007  ? 163 VAL A N   1 
ATOM   1030 C CA  . VAL A 1 164 ? 132.29830 -14.33690 12.43560  1.000 21.15276  ? 163 VAL A CA  1 
ATOM   1031 C C   . VAL A 1 164 ? 132.31558 -15.17178 11.15761  1.000 23.29124  ? 163 VAL A C   1 
ATOM   1032 O O   . VAL A 1 164 ? 133.28330 -15.89314 10.88454  1.000 22.46512  ? 163 VAL A O   1 
ATOM   1033 C CB  . VAL A 1 164 ? 133.29971 -13.17394 12.31576  1.000 21.97731  ? 163 VAL A CB  1 
ATOM   1034 C CG1 . VAL A 1 164 ? 133.09010 -12.41658 11.00333  1.000 23.28598  ? 163 VAL A CG1 1 
ATOM   1035 C CG2 . VAL A 1 164 ? 133.16174 -12.24206 13.51696  1.000 22.29814  ? 163 VAL A CG2 1 
ATOM   1036 N N   . LEU A 1 165 ? 131.26261 -15.04014 10.36146  1.000 21.35956  ? 164 LEU A N   1 
ATOM   1037 C CA  . LEU A 1 165 ? 131.17008 -15.65982 9.04351   1.000 22.34900  ? 164 LEU A CA  1 
ATOM   1038 C C   . LEU A 1 165 ? 131.25521 -14.55725 7.99351   1.000 22.25864  ? 164 LEU A C   1 
ATOM   1039 O O   . LEU A 1 165 ? 130.43793 -13.63301 7.99755   1.000 23.30853  ? 164 LEU A O   1 
ATOM   1040 C CB  . LEU A 1 165 ? 129.85683 -16.42919 8.92945   1.000 25.53826  ? 164 LEU A CB  1 
ATOM   1041 C CG  . LEU A 1 165 ? 129.65201 -17.35658 7.74004   1.000 27.58662  ? 164 LEU A CG  1 
ATOM   1042 C CD1 . LEU A 1 165 ? 130.51655 -18.60282 7.92351   1.000 25.17338  ? 164 LEU A CD1 1 
ATOM   1043 C CD2 . LEU A 1 165 ? 128.15473 -17.71048 7.63513   1.000 24.94683  ? 164 LEU A CD2 1 
ATOM   1044 N N   . HIS A 1 166 ? 132.23654 -14.65129 7.09622   1.000 19.86300  ? 165 HIS A N   1 
ATOM   1045 C CA  . HIS A 1 166 ? 132.45822 -13.57631 6.12744   1.000 19.73241  ? 165 HIS A CA  1 
ATOM   1046 C C   . HIS A 1 166 ? 131.35469 -13.53628 5.07126   1.000 20.39358  ? 165 HIS A C   1 
ATOM   1047 O O   . HIS A 1 166 ? 130.83503 -12.45946 4.73870   1.000 22.92040  ? 165 HIS A O   1 
ATOM   1048 C CB  . HIS A 1 166 ? 133.84190 -13.75462 5.48806   1.000 22.30843  ? 165 HIS A CB  1 
ATOM   1049 C CG  . HIS A 1 166 ? 134.24906 -12.63434 4.57922   1.000 24.45827  ? 165 HIS A CG  1 
ATOM   1050 N ND1 . HIS A 1 166 ? 133.72795 -12.48011 3.31539   1.000 23.07134  ? 165 HIS A ND1 1 
ATOM   1051 C CD2 . HIS A 1 166 ? 135.12998 -11.61859 4.74796   1.000 23.00990  ? 165 HIS A CD2 1 
ATOM   1052 C CE1 . HIS A 1 166 ? 134.27349 -11.42376 2.73818   1.000 24.22039  ? 165 HIS A CE1 1 
ATOM   1053 N NE2 . HIS A 1 166 ? 135.12748 -10.88210 3.58679   1.000 22.14178  ? 165 HIS A NE2 1 
ATOM   1054 N N   . ARG A 1 167 ? 131.00690 -14.69761 4.50958   1.000 22.17155  ? 166 ARG A N   1 
ATOM   1055 C CA  . ARG A 1 167 ? 129.94163 -14.90141 3.52605   1.000 20.80278  ? 166 ARG A CA  1 
ATOM   1056 C C   . ARG A 1 167 ? 130.22771 -14.27212 2.16657   1.000 21.23332  ? 166 ARG A C   1 
ATOM   1057 O O   . ARG A 1 167 ? 129.33158 -14.21797 1.32191   1.000 22.80764  ? 166 ARG A O   1 
ATOM   1058 C CB  . ARG A 1 167 ? 128.58271 -14.39588 4.03369   1.000 20.64688  ? 166 ARG A CB  1 
ATOM   1059 C CG  . ARG A 1 167 ? 128.10328 -15.15240 5.27977   1.000 21.53531  ? 166 ARG A CG  1 
ATOM   1060 C CD  . ARG A 1 167 ? 126.59620 -15.06776 5.43562   1.000 25.20717  ? 166 ARG A CD  1 
ATOM   1061 N NE  . ARG A 1 167 ? 126.12481 -13.71089 5.72177   1.000 24.98056  ? 166 ARG A NE  1 
ATOM   1062 C CZ  . ARG A 1 167 ? 124.86162 -13.41280 5.99692   1.000 32.25876  ? 166 ARG A CZ  1 
ATOM   1063 N NH1 . ARG A 1 167 ? 123.91986 -14.34699 6.00841   1.000 28.19159  ? 166 ARG A NH1 1 
ATOM   1064 N NH2 . ARG A 1 167 ? 124.53443 -12.14976 6.26454   1.000 25.08141  ? 166 ARG A NH2 1 
ATOM   1065 N N   . ASP A 1 168 ? 131.44902 -13.81425 1.91121   1.000 18.46128  ? 167 ASP A N   1 
ATOM   1066 C CA  . ASP A 1 168 ? 131.75355 -13.27748 0.58714   1.000 20.77431  ? 167 ASP A CA  1 
ATOM   1067 C C   . ASP A 1 168 ? 133.22386 -13.49482 0.26410   1.000 21.46938  ? 167 ASP A C   1 
ATOM   1068 O O   . ASP A 1 168 ? 133.89335 -12.60998 -0.27943  1.000 21.75132  ? 167 ASP A O   1 
ATOM   1069 C CB  . ASP A 1 168 ? 131.38011 -11.79391 0.48387   1.000 22.94782  ? 167 ASP A CB  1 
ATOM   1070 C CG  . ASP A 1 168 ? 131.27724 -11.30920 -0.96238  1.000 29.70606  ? 167 ASP A CG  1 
ATOM   1071 O OD1 . ASP A 1 168 ? 131.18757 -12.15939 -1.88503  1.000 23.23170  ? 167 ASP A OD1 1 
ATOM   1072 O OD2 . ASP A 1 168 ? 131.29225 -10.07340 -1.17565  1.000 27.04651  ? 167 ASP A OD2 1 
ATOM   1073 N N   . ILE A 1 169 ? 133.74276 -14.67822 0.59617   1.000 20.71409  ? 168 ILE A N   1 
ATOM   1074 C CA  . ILE A 1 169 ? 135.11892 -15.01532 0.24596   1.000 21.09350  ? 168 ILE A CA  1 
ATOM   1075 C C   . ILE A 1 169 ? 135.23004 -15.08858 -1.27409  1.000 19.13434  ? 168 ILE A C   1 
ATOM   1076 O O   . ILE A 1 169 ? 134.50207 -15.84486 -1.92797  1.000 19.20320  ? 168 ILE A O   1 
ATOM   1077 C CB  . ILE A 1 169 ? 135.53708 -16.34478 0.88969   1.000 20.98413  ? 168 ILE A CB  1 
ATOM   1078 C CG1 . ILE A 1 169 ? 135.43441 -16.27104 2.41949   1.000 20.88083  ? 168 ILE A CG1 1 
ATOM   1079 C CG2 . ILE A 1 169 ? 136.96617 -16.70705 0.47782   1.000 20.86711  ? 168 ILE A CG2 1 
ATOM   1080 C CD1 . ILE A 1 169 ? 135.40412 -17.65781 3.08295   1.000 23.29420  ? 168 ILE A CD1 1 
ATOM   1081 N N   . LYS A 1 170 ? 136.13155 -14.29202 -1.84480  1.000 18.17688  ? 169 LYS A N   1 
ATOM   1082 C CA  . LYS A 1 170 ? 136.40563 -14.32102 -3.27800  1.000 21.21882  ? 169 LYS A CA  1 
ATOM   1083 C C   . LYS A 1 170 ? 137.72553 -13.59801 -3.49795  1.000 19.90845  ? 169 LYS A C   1 
ATOM   1084 O O   . LYS A 1 170 ? 138.21285 -12.89283 -2.61044  1.000 19.79266  ? 169 LYS A O   1 
ATOM   1085 C CB  . LYS A 1 170 ? 135.27600 -13.66981 -4.09139  1.000 20.96425  ? 169 LYS A CB  1 
ATOM   1086 C CG  . LYS A 1 170 ? 134.89253 -12.24160 -3.66064  1.000 20.00240  ? 169 LYS A CG  1 
ATOM   1087 C CD  . LYS A 1 170 ? 133.90091 -11.63652 -4.69404  1.000 19.20199  ? 169 LYS A CD  1 
ATOM   1088 C CE  . LYS A 1 170 ? 133.35313 -10.25502 -4.25994  1.000 23.51904  ? 169 LYS A CE  1 
ATOM   1089 N NZ  . LYS A 1 170 ? 132.45667 -9.71106  -5.36731  1.000 23.93709  ? 169 LYS A NZ  1 
ATOM   1090 N N   . ASP A 1 171 ? 138.29224 -13.74833 -4.70282  1.000 16.98250  ? 170 ASP A N   1 
ATOM   1091 C CA  . ASP A 1 171 ? 139.58683 -13.11552 -4.95036  1.000 18.26713  ? 170 ASP A CA  1 
ATOM   1092 C C   . ASP A 1 171 ? 139.50595 -11.59480 -4.81807  1.000 21.55877  ? 170 ASP A C   1 
ATOM   1093 O O   . ASP A 1 171 ? 140.46182 -10.96288 -4.35135  1.000 19.24985  ? 170 ASP A O   1 
ATOM   1094 C CB  . ASP A 1 171 ? 140.16309 -13.53829 -6.31489  1.000 17.94355  ? 170 ASP A CB  1 
ATOM   1095 C CG  . ASP A 1 171 ? 139.22933 -13.28349 -7.49631  1.000 24.10387  ? 170 ASP A CG  1 
ATOM   1096 O OD1 . ASP A 1 171 ? 138.14375 -12.68912 -7.34384  1.000 19.95696  ? 170 ASP A OD1 1 
ATOM   1097 O OD2 . ASP A 1 171 ? 139.61364 -13.70338 -8.61134  1.000 22.21666  ? 170 ASP A OD2 1 
ATOM   1098 N N   . GLU A 1 172 ? 138.36520 -10.99728 -5.17373  1.000 18.42207  ? 171 GLU A N   1 
ATOM   1099 C CA  . GLU A 1 172 ? 138.21519 -9.54831  -5.05112  1.000 21.25109  ? 171 GLU A CA  1 
ATOM   1100 C C   . GLU A 1 172 ? 138.34237 -9.06574  -3.61016  1.000 20.09308  ? 171 GLU A C   1 
ATOM   1101 O O   . GLU A 1 172 ? 138.69511 -7.90128  -3.38199  1.000 21.68240  ? 171 GLU A O   1 
ATOM   1102 C CB  . GLU A 1 172 ? 136.86102 -9.09566  -5.57977  1.000 19.77636  ? 171 GLU A CB  1 
ATOM   1103 C CG  . GLU A 1 172 ? 136.57150 -9.44749  -7.03327  1.000 21.05135  ? 171 GLU A CG  1 
ATOM   1104 C CD  . GLU A 1 172 ? 135.23763 -8.88144  -7.43828  1.000 27.04646  ? 171 GLU A CD  1 
ATOM   1105 O OE1 . GLU A 1 172 ? 135.10552 -7.63216  -7.44103  1.000 27.36743  ? 171 GLU A OE1 1 
ATOM   1106 O OE2 . GLU A 1 172 ? 134.32434 -9.68184  -7.72586  1.000 26.79783  ? 171 GLU A OE2 1 
ATOM   1107 N N   . ASN A 1 173 ? 138.01609 -9.91429  -2.63430  1.000 19.11726  ? 172 ASN A N   1 
ATOM   1108 C CA  . ASN A 1 173 ? 138.01711 -9.52254  -1.23070  1.000 21.17937  ? 172 ASN A CA  1 
ATOM   1109 C C   . ASN A 1 173 ? 139.26089 -9.99441  -0.49363  1.000 20.91113  ? 172 ASN A C   1 
ATOM   1110 O O   . ASN A 1 173 ? 139.23217 -10.13724 0.73068   1.000 21.84597  ? 172 ASN A O   1 
ATOM   1111 C CB  . ASN A 1 173 ? 136.74423 -10.02719 -0.54708  1.000 20.88752  ? 172 ASN A CB  1 
ATOM   1112 C CG  . ASN A 1 173 ? 135.53199 -9.23920  -0.99379  1.000 26.26248  ? 172 ASN A CG  1 
ATOM   1113 O OD1 . ASN A 1 173 ? 135.68622 -8.10057  -1.43249  1.000 24.37698  ? 172 ASN A OD1 1 
ATOM   1114 N ND2 . ASN A 1 173 ? 134.34018 -9.83112  -0.92048  1.000 21.51896  ? 172 ASN A ND2 1 
ATOM   1115 N N   . ILE A 1 174 ? 140.35682 -10.21052 -1.21662  1.000 19.50336  ? 173 ILE A N   1 
ATOM   1116 C CA  . ILE A 1 174 ? 141.62965 -10.63607 -0.64745  1.000 21.25125  ? 173 ILE A CA  1 
ATOM   1117 C C   . ILE A 1 174 ? 142.70234 -9.67626  -1.14705  1.000 22.61475  ? 173 ILE A C   1 
ATOM   1118 O O   . ILE A 1 174 ? 142.88150 -9.51460  -2.36131  1.000 23.01609  ? 173 ILE A O   1 
ATOM   1119 C CB  . ILE A 1 174 ? 141.96812 -12.08403 -1.03978  1.000 21.12959  ? 173 ILE A CB  1 
ATOM   1120 C CG1 . ILE A 1 174 ? 140.96878 -13.04848 -0.37171  1.000 20.88637  ? 173 ILE A CG1 1 
ATOM   1121 C CG2 . ILE A 1 174 ? 143.41460 -12.42437 -0.66689  1.000 22.40681  ? 173 ILE A CG2 1 
ATOM   1122 C CD1 . ILE A 1 174 ? 140.94699 -14.45549 -0.98649  1.000 21.80863  ? 173 ILE A CD1 1 
ATOM   1123 N N   . LEU A 1 175 ? 143.40330 -9.03511  -0.22126  1.000 22.68050  ? 174 LEU A N   1 
ATOM   1124 C CA  . LEU A 1 175 ? 144.50487 -8.14389  -0.55897  1.000 20.88410  ? 174 LEU A CA  1 
ATOM   1125 C C   . LEU A 1 175 ? 145.81956 -8.87565  -0.36375  1.000 22.80225  ? 174 LEU A C   1 
ATOM   1126 O O   . LEU A 1 175 ? 145.98043 -9.62274  0.60345   1.000 24.99567  ? 174 LEU A O   1 
ATOM   1127 C CB  . LEU A 1 175 ? 144.48270 -6.88749  0.31470   1.000 21.35623  ? 174 LEU A CB  1 
ATOM   1128 C CG  . LEU A 1 175 ? 143.25241 -5.98791  0.15737   1.000 24.19821  ? 174 LEU A CG  1 
ATOM   1129 C CD1 . LEU A 1 175 ? 143.40979 -4.73928  1.02208   1.000 27.75808  ? 174 LEU A CD1 1 
ATOM   1130 C CD2 . LEU A 1 175 ? 143.01612 -5.61441  -1.30290  1.000 23.56434  ? 174 LEU A CD2 1 
ATOM   1131 N N   . ILE A 1 176 ? 146.76315 -8.65043  -1.27651  1.000 21.33861  ? 175 ILE A N   1 
ATOM   1132 C CA  . ILE A 1 176 ? 148.11086 -9.20224  -1.16750  1.000 20.15666  ? 175 ILE A CA  1 
ATOM   1133 C C   . ILE A 1 176 ? 149.05322 -8.07783  -0.75804  1.000 25.29638  ? 175 ILE A C   1 
ATOM   1134 O O   . ILE A 1 176 ? 149.19055 -7.08383  -1.48128  1.000 27.12239  ? 175 ILE A O   1 
ATOM   1135 C CB  . ILE A 1 176 ? 148.59531 -9.82529  -2.48681  1.000 23.74757  ? 175 ILE A CB  1 
ATOM   1136 C CG1 . ILE A 1 176 ? 147.60812 -10.86046 -3.03188  1.000 23.71697  ? 175 ILE A CG1 1 
ATOM   1137 C CG2 . ILE A 1 176 ? 149.98543 -10.43715 -2.30688  1.000 26.43102  ? 175 ILE A CG2 1 
ATOM   1138 C CD1 . ILE A 1 176 ? 147.83990 -11.11485 -4.54127  1.000 22.57970  ? 175 ILE A CD1 1 
ATOM   1139 N N   . ASP A 1 177 ? 149.70584 -8.23776  0.39101   1.000 26.97805  ? 176 ASP A N   1 
ATOM   1140 C CA  . ASP A 1 177 ? 150.85348 -7.41314  0.74984   1.000 28.53104  ? 176 ASP A CA  1 
ATOM   1141 C C   . ASP A 1 177 ? 152.04021 -7.94171  -0.04197  1.000 32.08236  ? 176 ASP A C   1 
ATOM   1142 O O   . ASP A 1 177 ? 152.58541 -9.00775  0.26745   1.000 29.41309  ? 176 ASP A O   1 
ATOM   1143 C CB  . ASP A 1 177 ? 151.09866 -7.45938  2.25726   1.000 30.15428  ? 176 ASP A CB  1 
ATOM   1144 C CG  . ASP A 1 177 ? 152.26258 -6.56744  2.70060   1.000 34.26546  ? 176 ASP A CG  1 
ATOM   1145 O OD1 . ASP A 1 177 ? 153.28511 -6.48885  1.99602   1.000 33.58455  ? 176 ASP A OD1 1 
ATOM   1146 O OD2 . ASP A 1 177 ? 152.15454 -5.95845  3.77543   1.000 33.52098  ? 176 ASP A OD2 1 
ATOM   1147 N N   . LEU A 1 178 ? 152.43220 -7.19839  -1.07453  1.000 28.19129  ? 177 LEU A N   1 
ATOM   1148 C CA  . LEU A 1 178 ? 153.38736 -7.71496  -2.04208  1.000 30.47408  ? 177 LEU A CA  1 
ATOM   1149 C C   . LEU A 1 178 ? 154.78984 -7.82908  -1.46630  1.000 36.73755  ? 177 LEU A C   1 
ATOM   1150 O O   . LEU A 1 178 ? 155.57838 -8.65181  -1.93949  1.000 39.89730  ? 177 LEU A O   1 
ATOM   1151 C CB  . LEU A 1 178 ? 153.39923 -6.82103  -3.27597  1.000 30.92212  ? 177 LEU A CB  1 
ATOM   1152 C CG  . LEU A 1 178 ? 152.11105 -6.86546  -4.09839  1.000 35.97943  ? 177 LEU A CG  1 
ATOM   1153 C CD1 . LEU A 1 178 ? 152.09192 -5.71909  -5.10374  1.000 32.74314  ? 177 LEU A CD1 1 
ATOM   1154 C CD2 . LEU A 1 178 ? 151.97380 -8.21965  -4.79678  1.000 30.25453  ? 177 LEU A CD2 1 
ATOM   1155 N N   . ASN A 1 179 ? 155.13560 -7.00819  -0.47526  1.000 35.67836  ? 178 ASN A N   1 
ATOM   1156 C CA  . ASN A 1 179 ? 156.47872 -7.10478  0.08317   1.000 33.68437  ? 178 ASN A CA  1 
ATOM   1157 C C   . ASN A 1 179 ? 156.57035 -8.17556  1.16559   1.000 32.44191  ? 178 ASN A C   1 
ATOM   1158 O O   . ASN A 1 179 ? 157.59627 -8.85679  1.26724   1.000 33.34220  ? 178 ASN A O   1 
ATOM   1159 C CB  . ASN A 1 179 ? 156.93910 -5.75350  0.63760   1.000 39.66816  ? 178 ASN A CB  1 
ATOM   1160 C CG  . ASN A 1 179 ? 157.36190 -4.77973  -0.45966  1.000 44.58613  ? 178 ASN A CG  1 
ATOM   1161 O OD1 . ASN A 1 179 ? 157.55649 -3.59459  -0.19905  1.000 57.20032  ? 178 ASN A OD1 1 
ATOM   1162 N ND2 . ASN A 1 179 ? 157.49306 -5.27225  -1.68924  1.000 44.58973  ? 178 ASN A ND2 1 
ATOM   1163 N N   . ARG A 1 180 ? 155.51327 -8.36074  1.96032   1.000 29.37217  ? 179 ARG A N   1 
ATOM   1164 C CA  . ARG A 1 180 ? 155.53760 -9.35118  3.03107   1.000 30.59561  ? 179 ARG A CA  1 
ATOM   1165 C C   . ARG A 1 180 ? 155.00721 -10.72191 2.60825   1.000 29.47316  ? 179 ARG A C   1 
ATOM   1166 O O   . ARG A 1 180 ? 155.22262 -11.70091 3.33759   1.000 26.51150  ? 179 ARG A O   1 
ATOM   1167 C CB  . ARG A 1 180 ? 154.74540 -8.83313  4.23628   1.000 33.71236  ? 179 ARG A CB  1 
ATOM   1168 C CG  . ARG A 1 180 ? 155.34302 -7.56189  4.84570   1.000 35.43676  ? 179 ARG A CG  1 
ATOM   1169 C CD  . ARG A 1 180 ? 154.61726 -7.12811  6.10709   1.000 37.06884  ? 179 ARG A CD  1 
ATOM   1170 N NE  . ARG A 1 180 ? 154.52604 -8.20588  7.08286   1.000 44.14747  ? 179 ARG A NE  1 
ATOM   1171 C CZ  . ARG A 1 180 ? 155.48917 -8.53488  7.93657   1.000 51.04604  ? 179 ARG A CZ  1 
ATOM   1172 N NH1 . ARG A 1 180 ? 156.64096 -7.88352  7.96559   1.000 47.53186  ? 179 ARG A NH1 1 
ATOM   1173 N NH2 . ARG A 1 180 ? 155.29129 -9.54436  8.78238   1.000 50.78221  ? 179 ARG A NH2 1 
ATOM   1174 N N   . GLY A 1 181 ? 154.33910 -10.81930 1.45552   1.000 26.77186  ? 180 GLY A N   1 
ATOM   1175 C CA  . GLY A 1 181 ? 153.75811 -12.08299 1.03018   1.000 25.90485  ? 180 GLY A CA  1 
ATOM   1176 C C   . GLY A 1 181 ? 152.59176 -12.53550 1.89056   1.000 30.53472  ? 180 GLY A C   1 
ATOM   1177 O O   . GLY A 1 181 ? 152.32770 -13.74034 1.98899   1.000 28.22147  ? 180 GLY A O   1 
ATOM   1178 N N   . GLU A 1 182 ? 151.87828 -11.59906 2.50837   1.000 24.76233  ? 181 GLU A N   1 
ATOM   1179 C CA  . GLU A 1 182 ? 150.75727 -11.90549 3.38804   1.000 26.98955  ? 181 GLU A CA  1 
ATOM   1180 C C   . GLU A 1 182 ? 149.44261 -11.48612 2.73988   1.000 25.87112  ? 181 GLU A C   1 
ATOM   1181 O O   . GLU A 1 182 ? 149.35338 -10.41091 2.13557   1.000 26.65063  ? 181 GLU A O   1 
ATOM   1182 C CB  . GLU A 1 182 ? 150.92356 -11.19944 4.74135   1.000 26.06143  ? 181 GLU A CB  1 
ATOM   1183 C CG  . GLU A 1 182 ? 152.12141 -11.69232 5.53750   1.000 31.47737  ? 181 GLU A CG  1 
ATOM   1184 C CD  . GLU A 1 182 ? 152.40061 -10.85700 6.78262   1.000 42.75975  ? 181 GLU A CD  1 
ATOM   1185 O OE1 . GLU A 1 182 ? 151.88061 -9.72921  6.87759   1.000 40.81076  ? 181 GLU A OE1 1 
ATOM   1186 O OE2 . GLU A 1 182 ? 153.15389 -11.32806 7.66167   1.000 46.38930  ? 181 GLU A OE2 1 
ATOM   1187 N N   . LEU A 1 183 ? 148.42589 -12.34438 2.86710   1.000 21.45178  ? 182 LEU A N   1 
ATOM   1188 C CA  . LEU A 1 183 ? 147.09003 -12.08611 2.34605   1.000 20.07068  ? 182 LEU A CA  1 
ATOM   1189 C C   . LEU A 1 183 ? 146.19392 -11.58670 3.47518   1.000 22.31545  ? 182 LEU A C   1 
ATOM   1190 O O   . LEU A 1 183 ? 146.33892 -12.01488 4.62405   1.000 24.46828  ? 182 LEU A O   1 
ATOM   1191 C CB  . LEU A 1 183 ? 146.49341 -13.35082 1.71763   1.000 19.05308  ? 182 LEU A CB  1 
ATOM   1192 C CG  . LEU A 1 183 ? 146.82091 -13.53203 0.22288   1.000 25.42132  ? 182 LEU A CG  1 
ATOM   1193 C CD1 . LEU A 1 183 ? 148.31844 -13.44612 -0.01377  1.000 28.53554  ? 182 LEU A CD1 1 
ATOM   1194 C CD2 . LEU A 1 183 ? 146.24137 -14.84554 -0.31792  1.000 25.00775  ? 182 LEU A CD2 1 
ATOM   1195 N N   . LYS A 1 184 ? 145.28648 -10.66509 3.14463   1.000 22.17157  ? 183 LYS A N   1 
ATOM   1196 C CA  . LYS A 1 184 ? 144.39497 -10.03417 4.11624   1.000 23.48379  ? 183 LYS A CA  1 
ATOM   1197 C C   . LYS A 1 184 ? 142.97087 -10.00012 3.57699   1.000 23.03596  ? 183 LYS A C   1 
ATOM   1198 O O   . LYS A 1 184 ? 142.74343 -9.53213  2.45529   1.000 21.48880  ? 183 LYS A O   1 
ATOM   1199 C CB  . LYS A 1 184 ? 144.83868 -8.59533  4.42493   1.000 25.33248  ? 183 LYS A CB  1 
ATOM   1200 C CG  . LYS A 1 184 ? 146.27562 -8.43868  4.89190   1.000 29.46250  ? 183 LYS A CG  1 
ATOM   1201 C CD  . LYS A 1 184 ? 146.42722 -8.88090  6.32691   1.000 35.75344  ? 183 LYS A CD  1 
ATOM   1202 C CE  . LYS A 1 184 ? 147.74779 -8.37722  6.91804   1.000 39.21662  ? 183 LYS A CE  1 
ATOM   1203 N NZ  . LYS A 1 184 ? 147.94782 -8.98328  8.26182   1.000 40.89951  ? 183 LYS A NZ  1 
ATOM   1204 N N   A LEU A 1 185 ? 142.02030 -10.48843 4.37578   0.600 23.29309  ? 184 LEU A N   1 
ATOM   1205 N N   B LEU A 1 185 ? 142.01877 -10.44599 4.39190   0.400 23.30179  ? 184 LEU A N   1 
ATOM   1206 C CA  A LEU A 1 185 ? 140.61204 -10.44431 4.00229   0.600 22.33221  ? 184 LEU A CA  1 
ATOM   1207 C CA  B LEU A 1 185 ? 140.61215 -10.47021 4.01083   0.400 22.35500  ? 184 LEU A CA  1 
ATOM   1208 C C   A LEU A 1 185 ? 140.04124 -9.05089  4.20218   0.600 23.49823  ? 184 LEU A C   1 
ATOM   1209 C C   B LEU A 1 185 ? 139.96163 -9.11014  4.25332   0.400 23.49437  ? 184 LEU A C   1 
ATOM   1210 O O   A LEU A 1 185 ? 140.34324 -8.37478  5.19236   0.600 24.01157  ? 184 LEU A O   1 
ATOM   1211 O O   B LEU A 1 185 ? 140.15700 -8.49772  5.30871   0.400 23.79224  ? 184 LEU A O   1 
ATOM   1212 C CB  A LEU A 1 185 ? 139.79386 -11.42904 4.83829   0.600 22.41708  ? 184 LEU A CB  1 
ATOM   1213 C CB  B LEU A 1 185 ? 139.89540 -11.55155 4.82266   0.400 22.39654  ? 184 LEU A CB  1 
ATOM   1214 C CG  A LEU A 1 185 ? 140.23156 -12.88413 4.87712   0.600 20.59161  ? 184 LEU A CG  1 
ATOM   1215 C CG  B LEU A 1 185 ? 138.67266 -12.30535 4.31228   0.400 23.32934  ? 184 LEU A CG  1 
ATOM   1216 C CD1 A LEU A 1 185 ? 139.21429 -13.70917 5.65415   0.600 21.83098  ? 184 LEU A CD1 1 
ATOM   1217 C CD1 B LEU A 1 185 ? 138.97082 -13.04382 3.02814   0.400 21.03251  ? 184 LEU A CD1 1 
ATOM   1218 C CD2 A LEU A 1 185 ? 140.41704 -13.42021 3.46068   0.600 21.08494  ? 184 LEU A CD2 1 
ATOM   1219 C CD2 B LEU A 1 185 ? 138.21636 -13.27775 5.40739   0.400 21.79424  ? 184 LEU A CD2 1 
ATOM   1220 N N   . ILE A 1 186 ? 139.18022 -8.63512  3.27526   1.000 21.03750  ? 185 ILE A N   1 
ATOM   1221 C CA  . ILE A 1 186 ? 138.47047 -7.36352  3.39242   1.000 23.30612  ? 185 ILE A CA  1 
ATOM   1222 C C   . ILE A 1 186 ? 136.98131 -7.57199  3.14894   1.000 24.84760  ? 185 ILE A C   1 
ATOM   1223 O O   . ILE A 1 186 ? 136.53439 -8.63908  2.72379   1.000 24.34840  ? 185 ILE A O   1 
ATOM   1224 C CB  . ILE A 1 186 ? 139.00622 -6.27639  2.43192   1.000 22.65455  ? 185 ILE A CB  1 
ATOM   1225 C CG1 . ILE A 1 186 ? 138.94780 -6.77177  0.97890   1.000 21.13825  ? 185 ILE A CG1 1 
ATOM   1226 C CG2 . ILE A 1 186 ? 140.40391 -5.87037  2.81919   1.000 23.88176  ? 185 ILE A CG2 1 
ATOM   1227 C CD1 . ILE A 1 186 ? 139.23775 -5.68814  -0.06207  1.000 23.09291  ? 185 ILE A CD1 1 
ATOM   1228 N N   . ASP A 1 187 ? 136.21894 -6.51560  3.45735   1.000 22.12459  ? 186 ASP A N   1 
ATOM   1229 C CA  . ASP A 1 187 ? 134.81393 -6.32621  3.10453   1.000 21.52336  ? 186 ASP A CA  1 
ATOM   1230 C C   . ASP A 1 187 ? 133.90401 -7.36294  3.75617   1.000 26.25941  ? 186 ASP A C   1 
ATOM   1231 O O   . ASP A 1 187 ? 133.39625 -8.28551  3.09935   1.000 25.97072  ? 186 ASP A O   1 
ATOM   1232 C CB  . ASP A 1 187 ? 134.64218 -6.30085  1.57608   1.000 26.04065  ? 186 ASP A CB  1 
ATOM   1233 C CG  . ASP A 1 187 ? 135.08724 -4.96050  0.96433   1.000 38.35129  ? 186 ASP A CG  1 
ATOM   1234 O OD1 . ASP A 1 187 ? 135.33740 -3.99483  1.72906   1.000 39.20570  ? 186 ASP A OD1 1 
ATOM   1235 O OD2 . ASP A 1 187 ? 135.19575 -4.86414  -0.28034  1.000 40.91410  ? 186 ASP A OD2 1 
ATOM   1236 N N   . PHE A 1 188 ? 133.66750 -7.17898  5.05292   1.000 24.14349  ? 187 PHE A N   1 
ATOM   1237 C CA  . PHE A 1 188 ? 132.77357 -8.01305  5.84067   1.000 23.18672  ? 187 PHE A CA  1 
ATOM   1238 C C   . PHE A 1 188 ? 131.32972 -7.53495  5.77484   1.000 26.69295  ? 187 PHE A C   1 
ATOM   1239 O O   . PHE A 1 188 ? 130.50748 -7.96682  6.59120   1.000 26.00950  ? 187 PHE A O   1 
ATOM   1240 C CB  . PHE A 1 188 ? 133.25357 -8.04076  7.29678   1.000 26.48982  ? 187 PHE A CB  1 
ATOM   1241 C CG  . PHE A 1 188 ? 134.47578 -8.89715  7.51920   1.000 22.01225  ? 187 PHE A CG  1 
ATOM   1242 C CD1 . PHE A 1 188 ? 135.73227 -8.45933  7.11295   1.000 23.77898  ? 187 PHE A CD1 1 
ATOM   1243 C CD2 . PHE A 1 188 ? 134.36565 -10.13412 8.15000   1.000 23.39558  ? 187 PHE A CD2 1 
ATOM   1244 C CE1 . PHE A 1 188 ? 136.86070 -9.25104  7.30932   1.000 27.19370  ? 187 PHE A CE1 1 
ATOM   1245 C CE2 . PHE A 1 188 ? 135.47931 -10.92785 8.35299   1.000 21.63122  ? 187 PHE A CE2 1 
ATOM   1246 C CZ  . PHE A 1 188 ? 136.73180 -10.49024 7.93827   1.000 22.86227  ? 187 PHE A CZ  1 
ATOM   1247 N N   . GLY A 1 189 ? 131.00686 -6.65249  4.82316   1.000 23.43138  ? 188 GLY A N   1 
ATOM   1248 C CA  . GLY A 1 189 ? 129.67600 -6.06957  4.73048   1.000 28.13539  ? 188 GLY A CA  1 
ATOM   1249 C C   . GLY A 1 189 ? 128.55791 -7.04802  4.42097   1.000 28.24600  ? 188 GLY A C   1 
ATOM   1250 O O   . GLY A 1 189 ? 127.38812 -6.70928  4.60602   1.000 32.15419  ? 188 GLY A O   1 
ATOM   1251 N N   . SER A 1 190 ? 128.87623 -8.23717  3.92533   1.000 22.06925  ? 189 SER A N   1 
ATOM   1252 C CA  . SER A 1 190 ? 127.85880 -9.26325  3.73402   1.000 24.48860  ? 189 SER A CA  1 
ATOM   1253 C C   . SER A 1 190 ? 127.88797 -10.32149 4.82735   1.000 25.18157  ? 189 SER A C   1 
ATOM   1254 O O   . SER A 1 190 ? 127.16495 -11.32029 4.73021   1.000 25.99973  ? 189 SER A O   1 
ATOM   1255 C CB  . SER A 1 190 ? 128.02999 -9.93222  2.36551   1.000 29.97682  ? 189 SER A CB  1 
ATOM   1256 O OG  . SER A 1 190 ? 128.03055 -8.96823  1.32778   1.000 35.85590  ? 189 SER A OG  1 
ATOM   1257 N N   . GLY A 1 191 ? 128.70892 -10.13196 5.85724   1.000 23.92027  ? 190 GLY A N   1 
ATOM   1258 C CA  . GLY A 1 191 ? 128.94571 -11.17075 6.83630   1.000 24.49348  ? 190 GLY A CA  1 
ATOM   1259 C C   . GLY A 1 191 ? 127.82339 -11.29990 7.84930   1.000 28.42684  ? 190 GLY A C   1 
ATOM   1260 O O   . GLY A 1 191 ? 126.81094 -10.59859 7.81244   1.000 27.83732  ? 190 GLY A O   1 
ATOM   1261 N N   . ALA A 1 192 ? 128.02167 -12.22866 8.78062   1.000 24.32438  ? 191 ALA A N   1 
ATOM   1262 C CA  . ALA A 1 192 ? 127.06212 -12.46109 9.85222   1.000 27.16881  ? 191 ALA A CA  1 
ATOM   1263 C C   . ALA A 1 192 ? 127.78958 -13.05148 11.04368  1.000 27.46727  ? 191 ALA A C   1 
ATOM   1264 O O   . ALA A 1 192 ? 128.90268 -13.57191 10.92539  1.000 25.49789  ? 191 ALA A O   1 
ATOM   1265 C CB  . ALA A 1 192 ? 125.93128 -13.40324 9.41388   1.000 24.39147  ? 191 ALA A CB  1 
ATOM   1266 N N   . LEU A 1 193 ? 127.14253 -12.97389 12.20259  1.000 25.34046  ? 192 LEU A N   1 
ATOM   1267 C CA  . LEU A 1 193 ? 127.56880 -13.79756 13.31836  1.000 24.17572  ? 192 LEU A CA  1 
ATOM   1268 C C   . LEU A 1 193 ? 127.45902 -15.26405 12.91666  1.000 24.89705  ? 192 LEU A C   1 
ATOM   1269 O O   . LEU A 1 193 ? 126.48852 -15.68024 12.27527  1.000 25.06707  ? 192 LEU A O   1 
ATOM   1270 C CB  . LEU A 1 193 ? 126.70989 -13.50956 14.55518  1.000 26.99882  ? 192 LEU A CB  1 
ATOM   1271 C CG  . LEU A 1 193 ? 126.73617 -12.05108 15.03099  1.000 30.73113  ? 192 LEU A CG  1 
ATOM   1272 C CD1 . LEU A 1 193 ? 125.74362 -11.83877 16.17414  1.000 35.03870  ? 192 LEU A CD1 1 
ATOM   1273 C CD2 . LEU A 1 193 ? 128.14084 -11.64856 15.46358  1.000 30.68383  ? 192 LEU A CD2 1 
ATOM   1274 N N   . LEU A 1 194 ? 128.47972 -16.04100 13.25658  1.000 26.07396  ? 193 LEU A N   1 
ATOM   1275 C CA  . LEU A 1 194 ? 128.44536 -17.46583 12.95767  1.000 26.34451  ? 193 LEU A CA  1 
ATOM   1276 C C   . LEU A 1 194 ? 127.43830 -18.16466 13.86897  1.000 27.59163  ? 193 LEU A C   1 
ATOM   1277 O O   . LEU A 1 194 ? 127.37596 -17.89389 15.07112  1.000 25.46712  ? 193 LEU A O   1 
ATOM   1278 C CB  . LEU A 1 194 ? 129.83760 -18.06339 13.13875  1.000 27.63153  ? 193 LEU A CB  1 
ATOM   1279 C CG  . LEU A 1 194 ? 130.03999 -19.56072 12.90842  1.000 31.11682  ? 193 LEU A CG  1 
ATOM   1280 C CD1 . LEU A 1 194 ? 129.83943 -19.90574 11.45397  1.000 28.96197  ? 193 LEU A CD1 1 
ATOM   1281 C CD2 . LEU A 1 194 ? 131.43611 -19.98111 13.38576  1.000 34.28642  ? 193 LEU A CD2 1 
ATOM   1282 N N   . LYS A 1 195 ? 126.62447 -19.04651 13.28689  1.000 26.50012  ? 194 LYS A N   1 
ATOM   1283 C CA  . LYS A 1 195 ? 125.67153 -19.85793 14.03918  1.000 27.15605  ? 194 LYS A CA  1 
ATOM   1284 C C   . LYS A 1 195 ? 125.66265 -21.26107 13.44704  1.000 29.98172  ? 194 LYS A C   1 
ATOM   1285 O O   . LYS A 1 195 ? 126.16779 -21.49268 12.34513  1.000 26.59817  ? 194 LYS A O   1 
ATOM   1286 C CB  . LYS A 1 195 ? 124.25631 -19.25770 14.00734  1.000 32.46622  ? 194 LYS A CB  1 
ATOM   1287 C CG  . LYS A 1 195 ? 123.63904 -19.23107 12.60601  1.000 30.27387  ? 194 LYS A CG  1 
ATOM   1288 C CD  . LYS A 1 195 ? 122.33281 -18.43821 12.54938  1.000 28.52431  ? 194 LYS A CD  1 
ATOM   1289 C CE  . LYS A 1 195 ? 121.75875 -18.46337 11.14439  1.000 32.63375  ? 194 LYS A CE  1 
ATOM   1290 N NZ  . LYS A 1 195 ? 120.47118 -17.74152 11.04051  1.000 35.20493  ? 194 LYS A NZ  1 
ATOM   1291 N N   . ASP A 1 196 ? 125.07602 -22.20056 14.18945  1.000 26.40190  ? 195 ASP A N   1 
ATOM   1292 C CA  . ASP A 1 196 ? 124.97956 -23.59474 13.76362  1.000 29.89480  ? 195 ASP A CA  1 
ATOM   1293 C C   . ASP A 1 196 ? 123.65550 -23.92714 13.08260  1.000 31.34013  ? 195 ASP A C   1 
ATOM   1294 O O   . ASP A 1 196 ? 123.51699 -25.02763 12.53420  1.000 30.50136  ? 195 ASP A O   1 
ATOM   1295 C CB  . ASP A 1 196 ? 125.18060 -24.53372 14.96783  1.000 24.97980  ? 195 ASP A CB  1 
ATOM   1296 C CG  . ASP A 1 196 ? 126.57035 -24.41789 15.57136  1.000 34.96524  ? 195 ASP A CG  1 
ATOM   1297 O OD1 . ASP A 1 196 ? 127.54457 -24.41940 14.79890  1.000 36.83286  ? 195 ASP A OD1 1 
ATOM   1298 O OD2 . ASP A 1 196 ? 126.68881 -24.31425 16.81500  1.000 37.68527  ? 195 ASP A OD2 1 
ATOM   1299 N N   . THR A 1 197 ? 122.68621 -23.01591 13.10815  1.000 30.66381  ? 196 THR A N   1 
ATOM   1300 C CA  . THR A 1 197 ? 121.40757 -23.21221 12.44629  1.000 29.28767  ? 196 THR A CA  1 
ATOM   1301 C C   . THR A 1 197 ? 121.45751 -22.64807 11.02691  1.000 33.20545  ? 196 THR A C   1 
ATOM   1302 O O   . THR A 1 197 ? 122.45041 -22.05302 10.60249  1.000 30.93683  ? 196 THR A O   1 
ATOM   1303 C CB  . THR A 1 197 ? 120.29400 -22.55634 13.25261  1.000 31.17183  ? 196 THR A CB  1 
ATOM   1304 O OG1 . THR A 1 197 ? 120.65871 -21.19864 13.53489  1.000 30.60034  ? 196 THR A OG1 1 
ATOM   1305 C CG2 . THR A 1 197 ? 120.06365 -23.31513 14.56959  1.000 33.30422  ? 196 THR A CG2 1 
ATOM   1306 N N   . VAL A 1 198 ? 120.35730 -22.81284 10.28302  1.000 29.74489  ? 197 VAL A N   1 
ATOM   1307 C CA  . VAL A 1 198 ? 120.37119 -22.52095 8.85010   1.000 28.10438  ? 197 VAL A CA  1 
ATOM   1308 C C   . VAL A 1 198 ? 120.33352 -21.01504 8.62100   1.000 29.77671  ? 197 VAL A C   1 
ATOM   1309 O O   . VAL A 1 198 ? 119.73059 -20.25590 9.38946   1.000 31.00781  ? 197 VAL A O   1 
ATOM   1310 C CB  . VAL A 1 198 ? 119.20033 -23.23771 8.14208   1.000 30.63874  ? 197 VAL A CB  1 
ATOM   1311 C CG1 . VAL A 1 198 ? 117.85615 -22.60912 8.52090   1.000 35.19316  ? 197 VAL A CG1 1 
ATOM   1312 C CG2 . VAL A 1 198 ? 119.40107 -23.24240 6.61880   1.000 29.76582  ? 197 VAL A CG2 1 
ATOM   1313 N N   . TYR A 1 199 ? 121.01986 -20.57359 7.56911   1.000 25.68166  ? 198 TYR A N   1 
ATOM   1314 C CA  . TYR A 1 199 ? 120.89699 -19.22029 7.05073   1.000 27.92490  ? 198 TYR A CA  1 
ATOM   1315 C C   . TYR A 1 199 ? 119.91206 -19.22899 5.88630   1.000 30.76473  ? 198 TYR A C   1 
ATOM   1316 O O   . TYR A 1 199 ? 119.97053 -20.11025 5.02545   1.000 29.83609  ? 198 TYR A O   1 
ATOM   1317 C CB  . TYR A 1 199 ? 122.24959 -18.68280 6.56497   1.000 25.83911  ? 198 TYR A CB  1 
ATOM   1318 C CG  . TYR A 1 199 ? 123.27821 -18.44804 7.64910   1.000 27.79268  ? 198 TYR A CG  1 
ATOM   1319 C CD1 . TYR A 1 199 ? 124.12349 -19.47090 8.07335   1.000 27.26311  ? 198 TYR A CD1 1 
ATOM   1320 C CD2 . TYR A 1 199 ? 123.41711 -17.19563 8.23884   1.000 25.58242  ? 198 TYR A CD2 1 
ATOM   1321 C CE1 . TYR A 1 199 ? 125.07948 -19.24638 9.05340   1.000 22.24248  ? 198 TYR A CE1 1 
ATOM   1322 C CE2 . TYR A 1 199 ? 124.36413 -16.96291 9.21093   1.000 23.30474  ? 198 TYR A CE2 1 
ATOM   1323 C CZ  . TYR A 1 199 ? 125.19307 -17.98880 9.61814   1.000 26.18011  ? 198 TYR A CZ  1 
ATOM   1324 O OH  . TYR A 1 199 ? 126.13028 -17.75280 10.60378  1.000 26.60403  ? 198 TYR A OH  1 
ATOM   1325 N N   . THR A 1 200 ? 119.00758 -18.24910 5.85814   1.000 34.25398  ? 199 THR A N   1 
ATOM   1326 C CA  . THR A 1 200 ? 118.06606 -18.10617 4.75079   1.000 30.43002  ? 199 THR A CA  1 
ATOM   1327 C C   . THR A 1 200 ? 118.17028 -16.74974 4.06400   1.000 36.78735  ? 199 THR A C   1 
ATOM   1328 O O   . THR A 1 200 ? 117.35065 -16.44464 3.19240   1.000 35.52594  ? 199 THR A O   1 
ATOM   1329 C CB  . THR A 1 200 ? 116.63041 -18.33653 5.22911   1.000 35.97429  ? 199 THR A CB  1 
ATOM   1330 O OG1 . THR A 1 200 ? 116.33185 -17.41727 6.28252   1.000 31.84405  ? 199 THR A OG1 1 
ATOM   1331 C CG2 . THR A 1 200 ? 116.46368 -19.76562 5.74423   1.000 36.66649  ? 199 THR A CG2 1 
ATOM   1332 N N   . ASP A 1 201 ? 119.14687 -15.93000 4.44061   1.000 34.20071  ? 200 ASP A N   1 
ATOM   1333 C CA  . ASP A 1 201 ? 119.45072 -14.66828 3.78023   1.000 37.36929  ? 200 ASP A CA  1 
ATOM   1334 C C   . ASP A 1 201 ? 120.85536 -14.75074 3.19805   1.000 31.94321  ? 200 ASP A C   1 
ATOM   1335 O O   . ASP A 1 201 ? 121.71338 -15.46082 3.73265   1.000 31.78370  ? 200 ASP A O   1 
ATOM   1336 C CB  . ASP A 1 201 ? 119.37419 -13.48695 4.76614   1.000 38.39619  ? 200 ASP A CB  1 
ATOM   1337 C CG  . ASP A 1 201 ? 120.45629 -13.55026 5.84893   1.000 52.66468  ? 200 ASP A CG  1 
ATOM   1338 O OD1 . ASP A 1 201 ? 120.49218 -14.53749 6.62640   1.000 53.01950  ? 200 ASP A OD1 1 
ATOM   1339 O OD2 . ASP A 1 201 ? 121.28219 -12.61066 5.92045   1.000 51.37671  ? 200 ASP A OD2 1 
ATOM   1340 N N   . PHE A 1 202 ? 121.09444 -14.02529 2.10497   1.000 31.56533  ? 201 PHE A N   1 
ATOM   1341 C CA  . PHE A 1 202 ? 122.42721 -14.01448 1.50231   1.000 30.57738  ? 201 PHE A CA  1 
ATOM   1342 C C   . PHE A 1 202 ? 122.57297 -12.80754 0.59072   1.000 31.82907  ? 201 PHE A C   1 
ATOM   1343 O O   . PHE A 1 202 ? 121.72447 -12.57581 -0.27409  1.000 34.50715  ? 201 PHE A O   1 
ATOM   1344 C CB  . PHE A 1 202 ? 122.69563 -15.29773 0.70864   1.000 26.68030  ? 201 PHE A CB  1 
ATOM   1345 C CG  . PHE A 1 202 ? 124.04255 -15.32430 0.02539   1.000 27.38214  ? 201 PHE A CG  1 
ATOM   1346 C CD1 . PHE A 1 202 ? 125.20635 -15.52973 0.75853   1.000 26.85229  ? 201 PHE A CD1 1 
ATOM   1347 C CD2 . PHE A 1 202 ? 124.14233 -15.14993 -1.34611  1.000 27.09117  ? 201 PHE A CD2 1 
ATOM   1348 C CE1 . PHE A 1 202 ? 126.45686 -15.56174 0.11879   1.000 23.89176  ? 201 PHE A CE1 1 
ATOM   1349 C CE2 . PHE A 1 202 ? 125.38155 -15.18499 -1.98936  1.000 28.05594  ? 201 PHE A CE2 1 
ATOM   1350 C CZ  . PHE A 1 202 ? 126.53526 -15.39115 -1.25262  1.000 25.13765  ? 201 PHE A CZ  1 
ATOM   1351 N N   A ASP A 1 203 ? 123.66870 -12.06972 0.77649   0.471 29.02244  ? 202 ASP A N   1 
ATOM   1352 N N   B ASP A 1 203 ? 123.64788 -12.03798 0.78028   0.529 29.01172  ? 202 ASP A N   1 
ATOM   1353 C CA  A ASP A 1 203 ? 123.96027 -10.86432 0.01687   0.471 32.84804  ? 202 ASP A CA  1 
ATOM   1354 C CA  B ASP A 1 203 ? 123.93046 -10.89523 -0.08143  0.529 32.77617  ? 202 ASP A CA  1 
ATOM   1355 C C   A ASP A 1 203 ? 125.35698 -10.90288 -0.59811  0.471 31.77101  ? 202 ASP A C   1 
ATOM   1356 C C   B ASP A 1 203 ? 125.38094 -10.88938 -0.55473  0.529 31.75429  ? 202 ASP A C   1 
ATOM   1357 O O   A ASP A 1 203 ? 125.80880 -9.89090  -1.14912  0.471 31.67033  ? 202 ASP A O   1 
ATOM   1358 O O   B ASP A 1 203 ? 125.89546 -9.83613  -0.94740  0.529 31.63980  ? 202 ASP A O   1 
ATOM   1359 C CB  A ASP A 1 203 ? 123.81611 -9.63327  0.92179   0.471 36.40618  ? 202 ASP A CB  1 
ATOM   1360 C CB  B ASP A 1 203 ? 123.60695 -9.57638  0.62765   0.529 35.96776  ? 202 ASP A CB  1 
ATOM   1361 C CG  A ASP A 1 203 ? 123.70520 -8.34712  0.14626   0.471 40.10174  ? 202 ASP A CG  1 
ATOM   1362 C CG  B ASP A 1 203 ? 122.13475 -9.43076  0.94511   0.529 37.33757  ? 202 ASP A CG  1 
ATOM   1363 O OD1 A ASP A 1 203 ? 123.34378 -8.40024  -1.04736  0.471 42.54967  ? 202 ASP A OD1 1 
ATOM   1364 O OD1 B ASP A 1 203 ? 121.30694 -9.63035  0.03526   0.529 43.31984  ? 202 ASP A OD1 1 
ATOM   1365 O OD2 A ASP A 1 203 ? 123.99028 -7.28274  0.73468   0.471 47.46245  ? 202 ASP A OD2 1 
ATOM   1366 O OD2 B ASP A 1 203 ? 121.80234 -9.12035  2.10975   0.529 46.74351  ? 202 ASP A OD2 1 
ATOM   1367 N N   . GLY A 1 204 ? 126.05151 -12.03645 -0.51840  1.000 28.30818  ? 203 GLY A N   1 
ATOM   1368 C CA  . GLY A 1 204 ? 127.39013 -12.15867 -1.05846  1.000 23.16088  ? 203 GLY A CA  1 
ATOM   1369 C C   . GLY A 1 204 ? 127.35666 -12.32713 -2.56655  1.000 25.62467  ? 203 GLY A C   1 
ATOM   1370 O O   . GLY A 1 204 ? 126.39291 -11.95704 -3.23851  1.000 27.62663  ? 203 GLY A O   1 
ATOM   1371 N N   . THR A 1 205 ? 128.42288 -12.91297 -3.10494  1.000 22.45644  ? 204 THR A N   1 
ATOM   1372 C CA  . THR A 1 205 ? 128.59252 -13.03020 -4.55263  1.000 21.38929  ? 204 THR A CA  1 
ATOM   1373 C C   . THR A 1 205 ? 127.98794 -14.33852 -5.04702  1.000 23.79148  ? 204 THR A C   1 
ATOM   1374 O O   . THR A 1 205 ? 128.40717 -15.41928 -4.62350  1.000 23.21232  ? 204 THR A O   1 
ATOM   1375 C CB  . THR A 1 205 ? 130.07322 -12.94132 -4.91950  1.000 21.37775  ? 204 THR A CB  1 
ATOM   1376 O OG1 . THR A 1 205 ? 130.59145 -11.69607 -4.44028  1.000 24.97751  ? 204 THR A OG1 1 
ATOM   1377 C CG2 . THR A 1 205 ? 130.27041 -13.00119 -6.44542  1.000 19.93042  ? 204 THR A CG2 1 
ATOM   1378 N N   . ARG A 1 206 ? 127.02616 -14.24310 -5.97223  1.000 22.12916  ? 205 ARG A N   1 
ATOM   1379 C CA  . ARG A 1 206 ? 126.25750 -15.42766 -6.34758  1.000 22.44176  ? 205 ARG A CA  1 
ATOM   1380 C C   . ARG A 1 206 ? 127.12699 -16.50527 -7.00088  1.000 21.98186  ? 205 ARG A C   1 
ATOM   1381 O O   . ARG A 1 206 ? 126.91003 -17.70066 -6.75777  1.000 23.60026  ? 205 ARG A O   1 
ATOM   1382 C CB  . ARG A 1 206 ? 125.09693 -15.03861 -7.26638  1.000 25.03923  ? 205 ARG A CB  1 
ATOM   1383 C CG  . ARG A 1 206 ? 124.15277 -16.19559 -7.57125  1.000 26.60812  ? 205 ARG A CG  1 
ATOM   1384 C CD  . ARG A 1 206 ? 122.94860 -15.70701 -8.38420  1.000 30.18189  ? 205 ARG A CD  1 
ATOM   1385 N NE  . ARG A 1 206 ? 121.95019 -16.74819 -8.58871  1.000 31.50853  ? 205 ARG A NE  1 
ATOM   1386 C CZ  . ARG A 1 206 ? 120.93267 -16.99074 -7.77219  1.000 33.82849  ? 205 ARG A CZ  1 
ATOM   1387 N NH1 . ARG A 1 206 ? 120.80248 -16.35706 -6.61743  1.000 32.01953  ? 205 ARG A NH1 1 
ATOM   1388 N NH2 . ARG A 1 206 ? 120.02128 -17.89238 -8.12457  1.000 30.67999  ? 205 ARG A NH2 1 
ATOM   1389 N N   . VAL A 1 207 ? 128.12108 -16.12089 -7.81720  1.000 20.71104  ? 206 VAL A N   1 
ATOM   1390 C CA  . VAL A 1 207 ? 128.95073 -17.14110 -8.47248  1.000 20.69441  ? 206 VAL A CA  1 
ATOM   1391 C C   . VAL A 1 207 ? 129.90800 -17.84338 -7.51503  1.000 22.42622  ? 206 VAL A C   1 
ATOM   1392 O O   . VAL A 1 207 ? 130.52530 -18.84876 -7.90282  1.000 22.06215  ? 206 VAL A O   1 
ATOM   1393 C CB  . VAL A 1 207 ? 129.76188 -16.59980 -9.67720  1.000 23.16453  ? 206 VAL A CB  1 
ATOM   1394 C CG1 . VAL A 1 207 ? 128.82416 -16.25977 -10.85230 1.000 23.39270  ? 206 VAL A CG1 1 
ATOM   1395 C CG2 . VAL A 1 207 ? 130.63509 -15.38747 -9.29755  1.000 21.65174  ? 206 VAL A CG2 1 
ATOM   1396 N N   . TYR A 1 208 ? 130.04118 -17.36913 -6.27273  1.000 21.54549  ? 207 TYR A N   1 
ATOM   1397 C CA  . TYR A 1 208 ? 130.74687 -18.11206 -5.23097  1.000 20.33899  ? 207 TYR A CA  1 
ATOM   1398 C C   . TYR A 1 208 ? 129.80253 -18.79055 -4.24847  1.000 21.27589  ? 207 TYR A C   1 
ATOM   1399 O O   . TYR A 1 208 ? 130.27162 -19.39814 -3.27555  1.000 19.58422  ? 207 TYR A O   1 
ATOM   1400 C CB  . TYR A 1 208 ? 131.69021 -17.18904 -4.43460  1.000 20.01796  ? 207 TYR A CB  1 
ATOM   1401 C CG  . TYR A 1 208 ? 132.97364 -16.79490 -5.14348  1.000 20.81065  ? 207 TYR A CG  1 
ATOM   1402 C CD1 . TYR A 1 208 ? 132.96887 -15.84547 -6.16702  1.000 18.68789  ? 207 TYR A CD1 1 
ATOM   1403 C CD2 . TYR A 1 208 ? 134.19316 -17.33966 -4.75276  1.000 18.70639  ? 207 TYR A CD2 1 
ATOM   1404 C CE1 . TYR A 1 208 ? 134.15145 -15.46212 -6.80852  1.000 20.98542  ? 207 TYR A CE1 1 
ATOM   1405 C CE2 . TYR A 1 208 ? 135.37870 -16.96556 -5.37799  1.000 18.88203  ? 207 TYR A CE2 1 
ATOM   1406 C CZ  . TYR A 1 208 ? 135.34963 -16.02611 -6.40395  1.000 18.39820  ? 207 TYR A CZ  1 
ATOM   1407 O OH  . TYR A 1 208 ? 136.52527 -15.64824 -7.00359  1.000 20.62194  ? 207 TYR A OH  1 
ATOM   1408 N N   . SER A 1 209 ? 128.46078 -18.65715 -4.45000  1.000 24.23933  ? 208 SER A N   1 
ATOM   1409 C CA  . SER A 1 209 ? 127.49088 -19.19847 -3.50738  1.000 20.83940  ? 208 SER A CA  1 
ATOM   1410 C C   . SER A 1 209 ? 127.19106 -20.65810 -3.84525  1.000 22.09244  ? 208 SER A C   1 
ATOM   1411 O O   . SER A 1 209 ? 127.34824 -21.07944 -4.99792  1.000 23.67107  ? 208 SER A O   1 
ATOM   1412 C CB  . SER A 1 209 ? 126.19623 -18.37289 -3.53360  1.000 23.33238  ? 208 SER A CB  1 
ATOM   1413 O OG  . SER A 1 209 ? 125.45967 -18.58730 -4.72579  1.000 25.95821  ? 208 SER A OG  1 
ATOM   1414 N N   . PRO A 1 210 ? 126.76400 -21.44297 -2.85648  1.000 22.43034  ? 209 PRO A N   1 
ATOM   1415 C CA  . PRO A 1 210 ? 126.68841 -22.89295 -3.03705  1.000 23.50062  ? 209 PRO A CA  1 
ATOM   1416 C C   . PRO A 1 210 ? 125.36337 -23.31668 -3.64342  1.000 25.98619  ? 209 PRO A C   1 
ATOM   1417 O O   . PRO A 1 210 ? 124.38578 -22.55268 -3.64171  1.000 24.55572  ? 209 PRO A O   1 
ATOM   1418 C CB  . PRO A 1 210 ? 126.83843 -23.41938 -1.60275  1.000 21.32156  ? 209 PRO A CB  1 
ATOM   1419 C CG  . PRO A 1 210 ? 126.13473 -22.37952 -0.78270  1.000 24.02117  ? 209 PRO A CG  1 
ATOM   1420 C CD  . PRO A 1 210 ? 126.49846 -21.05650 -1.45479  1.000 22.84173  ? 209 PRO A CD  1 
ATOM   1421 N N   . PRO A 1 211 ? 125.28455 -24.54927 -4.15070  1.000 22.03345  ? 210 PRO A N   1 
ATOM   1422 C CA  . PRO A 1 211 ? 124.05943 -24.96825 -4.85332  1.000 23.67673  ? 210 PRO A CA  1 
ATOM   1423 C C   . PRO A 1 211 ? 122.84404 -25.03233 -3.95492  1.000 26.44793  ? 210 PRO A C   1 
ATOM   1424 O O   . PRO A 1 211 ? 121.72613 -24.83320 -4.44652  1.000 26.80060  ? 210 PRO A O   1 
ATOM   1425 C CB  . PRO A 1 211 ? 124.41873 -26.35485 -5.40649  1.000 27.43785  ? 210 PRO A CB  1 
ATOM   1426 C CG  . PRO A 1 211 ? 125.62685 -26.79674 -4.61449  1.000 27.78124  ? 210 PRO A CG  1 
ATOM   1427 C CD  . PRO A 1 211 ? 126.35348 -25.55624 -4.22644  1.000 26.09706  ? 210 PRO A CD  1 
ATOM   1428 N N   . GLU A 1 212 ? 123.01805 -25.31343 -2.65682  1.000 25.23469  ? 211 GLU A N   1 
ATOM   1429 C CA  . GLU A 1 212 ? 121.86388 -25.32015 -1.76625  1.000 26.41715  ? 211 GLU A CA  1 
ATOM   1430 C C   . GLU A 1 212 ? 121.26803 -23.92506 -1.62193  1.000 27.19511  ? 211 GLU A C   1 
ATOM   1431 O O   . GLU A 1 212 ? 120.06103 -23.79334 -1.39848  1.000 29.14495  ? 211 GLU A O   1 
ATOM   1432 C CB  . GLU A 1 212 ? 122.24184 -25.90119 -0.39259  1.000 27.41158  ? 211 GLU A CB  1 
ATOM   1433 C CG  . GLU A 1 212 ? 123.35104 -25.14611 0.38053   1.000 26.13732  ? 211 GLU A CG  1 
ATOM   1434 C CD  . GLU A 1 212 ? 124.76998 -25.61685 0.05293   1.000 27.09453  ? 211 GLU A CD  1 
ATOM   1435 O OE1 . GLU A 1 212 ? 124.97886 -26.21517 -1.02767  1.000 25.51136  ? 211 GLU A OE1 1 
ATOM   1436 O OE2 . GLU A 1 212 ? 125.67996 -25.38072 0.88734   1.000 25.66570  ? 211 GLU A OE2 1 
ATOM   1437 N N   . TRP A 1 213 ? 122.08535 -22.87422 -1.73654  1.000 27.52591  ? 212 TRP A N   1 
ATOM   1438 C CA  . TRP A 1 213 ? 121.52816 -21.52379 -1.76216  1.000 25.56000  ? 212 TRP A CA  1 
ATOM   1439 C C   . TRP A 1 213 ? 120.77449 -21.27629 -3.06888  1.000 29.13559  ? 212 TRP A C   1 
ATOM   1440 O O   . TRP A 1 213 ? 119.64312 -20.77036 -3.06341  1.000 30.51099  ? 212 TRP A O   1 
ATOM   1441 C CB  . TRP A 1 213 ? 122.62966 -20.47309 -1.56690  1.000 24.62154  ? 212 TRP A CB  1 
ATOM   1442 C CG  . TRP A 1 213 ? 122.14146 -19.08287 -1.92498  1.000 27.95190  ? 212 TRP A CG  1 
ATOM   1443 C CD1 . TRP A 1 213 ? 122.48069 -18.34618 -3.02999  1.000 28.76883  ? 212 TRP A CD1 1 
ATOM   1444 C CD2 . TRP A 1 213 ? 121.17689 -18.30318 -1.20575  1.000 26.99863  ? 212 TRP A CD2 1 
ATOM   1445 N NE1 . TRP A 1 213 ? 121.80189 -17.14558 -3.02445  1.000 27.23404  ? 212 TRP A NE1 1 
ATOM   1446 C CE2 . TRP A 1 213 ? 120.99530 -17.09815 -1.91652  1.000 27.32187  ? 212 TRP A CE2 1 
ATOM   1447 C CE3 . TRP A 1 213 ? 120.45840 -18.50161 -0.01572  1.000 30.06207  ? 212 TRP A CE3 1 
ATOM   1448 C CZ2 . TRP A 1 213 ? 120.11692 -16.09952 -1.48418  1.000 29.55424  ? 212 TRP A CZ2 1 
ATOM   1449 C CZ3 . TRP A 1 213 ? 119.58970 -17.50404 0.41285   1.000 32.35406  ? 212 TRP A CZ3 1 
ATOM   1450 C CH2 . TRP A 1 213 ? 119.42600 -16.32288 -0.32242  1.000 29.89991  ? 212 TRP A CH2 1 
ATOM   1451 N N   . ILE A 1 214 ? 121.38858 -21.62956 -4.20152  1.000 26.91453  ? 213 ILE A N   1 
ATOM   1452 C CA  . ILE A 1 214 ? 120.72577 -21.46401 -5.50036  1.000 27.05647  ? 213 ILE A CA  1 
ATOM   1453 C C   . ILE A 1 214 ? 119.39710 -22.20768 -5.51820  1.000 26.96329  ? 213 ILE A C   1 
ATOM   1454 O O   . ILE A 1 214 ? 118.36352 -21.65944 -5.91988  1.000 29.73212  ? 213 ILE A O   1 
ATOM   1455 C CB  . ILE A 1 214 ? 121.64420 -21.94378 -6.64074  1.000 24.57615  ? 213 ILE A CB  1 
ATOM   1456 C CG1 . ILE A 1 214 ? 123.00337 -21.22859 -6.60394  1.000 28.40474  ? 213 ILE A CG1 1 
ATOM   1457 C CG2 . ILE A 1 214 ? 120.94146 -21.79731 -8.00425  1.000 30.15240  ? 213 ILE A CG2 1 
ATOM   1458 C CD1 . ILE A 1 214 ? 122.96795 -19.73092 -6.88232  1.000 23.60449  ? 213 ILE A CD1 1 
ATOM   1459 N N   . ARG A 1 215 ? 119.40053 -23.47024 -5.07342  1.000 28.25838  ? 214 ARG A N   1 
ATOM   1460 C CA  . ARG A 1 215 ? 118.20676 -24.30703 -5.19303  1.000 32.00332  ? 214 ARG A CA  1 
ATOM   1461 C C   . ARG A 1 215 ? 117.15114 -23.96732 -4.14752  1.000 34.05519  ? 214 ARG A C   1 
ATOM   1462 O O   . ARG A 1 215 ? 115.95968 -23.88563 -4.46979  1.000 33.40526  ? 214 ARG A O   1 
ATOM   1463 C CB  . ARG A 1 215 ? 118.57338 -25.78638 -5.07410  1.000 34.31824  ? 214 ARG A CB  1 
ATOM   1464 C CG  . ARG A 1 215 ? 119.23218 -26.41430 -6.29244  1.000 37.07173  ? 214 ARG A CG  1 
ATOM   1465 C CD  . ARG A 1 215 ? 119.26338 -27.92982 -6.10254  1.000 41.44662  ? 214 ARG A CD  1 
ATOM   1466 N NE  . ARG A 1 215 ? 119.89930 -28.62814 -7.21161  1.000 53.98058  ? 214 ARG A NE  1 
ATOM   1467 C CZ  . ARG A 1 215 ? 119.24642 -29.14548 -8.24406  1.000 55.62475  ? 214 ARG A CZ  1 
ATOM   1468 N NH1 . ARG A 1 215 ? 117.92849 -29.06857 -8.33664  1.000 58.10161  ? 214 ARG A NH1 1 
ATOM   1469 N NH2 . ARG A 1 215 ? 119.93354 -29.75260 -9.20991  1.000 50.33048  ? 214 ARG A NH2 1 
ATOM   1470 N N   . TYR A 1 216 ? 117.56156 -23.80075 -2.88377  1.000 33.25931  ? 215 TYR A N   1 
ATOM   1471 C CA  . TYR A 1 216 ? 116.62780 -23.78676 -1.76019  1.000 36.41659  ? 215 TYR A CA  1 
ATOM   1472 C C   . TYR A 1 216 ? 116.65394 -22.51859 -0.91935  1.000 31.67926  ? 215 TYR A C   1 
ATOM   1473 O O   . TYR A 1 216 ? 115.86652 -22.41469 0.03031   1.000 32.50588  ? 215 TYR A O   1 
ATOM   1474 C CB  . TYR A 1 216 ? 116.89343 -24.97647 -0.82584  1.000 34.28417  ? 215 TYR A CB  1 
ATOM   1475 C CG  . TYR A 1 216 ? 117.06866 -26.29785 -1.53150  1.000 38.92804  ? 215 TYR A CG  1 
ATOM   1476 C CD1 . TYR A 1 216 ? 116.02789 -26.86924 -2.25590  1.000 43.43598  ? 215 TYR A CD1 1 
ATOM   1477 C CD2 . TYR A 1 216 ? 118.27303 -26.98164 -1.45953  1.000 38.42263  ? 215 TYR A CD2 1 
ATOM   1478 C CE1 . TYR A 1 216 ? 116.18991 -28.08473 -2.90116  1.000 45.08637  ? 215 TYR A CE1 1 
ATOM   1479 C CE2 . TYR A 1 216 ? 118.44320 -28.19291 -2.09356  1.000 41.80021  ? 215 TYR A CE2 1 
ATOM   1480 C CZ  . TYR A 1 216 ? 117.40266 -28.74127 -2.81290  1.000 48.89975  ? 215 TYR A CZ  1 
ATOM   1481 O OH  . TYR A 1 216 ? 117.58726 -29.94914 -3.44458  1.000 58.55893  ? 215 TYR A OH  1 
ATOM   1482 N N   . HIS A 1 217 ? 117.53547 -21.57047 -1.21686  1.000 32.26930  ? 216 HIS A N   1 
ATOM   1483 C CA  . HIS A 1 217 ? 117.71532 -20.38028 -0.38649  1.000 33.40508  ? 216 HIS A CA  1 
ATOM   1484 C C   . HIS A 1 217 ? 117.97112 -20.74881 1.07304   1.000 33.55250  ? 216 HIS A C   1 
ATOM   1485 O O   . HIS A 1 217 ? 117.45146 -20.12150 1.99935   1.000 31.08888  ? 216 HIS A O   1 
ATOM   1486 C CB  . HIS A 1 217 ? 116.52615 -19.42622 -0.52680  1.000 37.72522  ? 216 HIS A CB  1 
ATOM   1487 C CG  . HIS A 1 217 ? 116.62492 -18.54107 -1.72972  1.000 44.26791  ? 216 HIS A CG  1 
ATOM   1488 N ND1 . HIS A 1 217 ? 115.77625 -17.47706 -1.95096  1.000 48.72635  ? 216 HIS A ND1 1 
ATOM   1489 C CD2 . HIS A 1 217 ? 117.48221 -18.56397 -2.77968  1.000 45.20240  ? 216 HIS A CD2 1 
ATOM   1490 C CE1 . HIS A 1 217 ? 116.10307 -16.88680 -3.08843  1.000 56.55860  ? 216 HIS A CE1 1 
ATOM   1491 N NE2 . HIS A 1 217 ? 117.13494 -17.52719 -3.61169  1.000 48.15247  ? 216 HIS A NE2 1 
ATOM   1492 N N   . ARG A 1 218 ? 118.78678 -21.78536 1.27409   1.000 31.56826  ? 217 ARG A N   1 
ATOM   1493 C CA  . ARG A 1 218 ? 119.17593 -22.27066 2.59361   1.000 30.28114  ? 217 ARG A CA  1 
ATOM   1494 C C   . ARG A 1 218 ? 120.61867 -22.74201 2.53738   1.000 29.88522  ? 217 ARG A C   1 
ATOM   1495 O O   . ARG A 1 218 ? 121.01933 -23.40960 1.57983   1.000 30.29866  ? 217 ARG A O   1 
ATOM   1496 C CB  . ARG A 1 218 ? 118.30768 -23.44437 3.06440   1.000 28.67236  ? 217 ARG A CB  1 
ATOM   1497 C CG  . ARG A 1 218 ? 116.83780 -23.12985 3.27967   1.000 32.85222  ? 217 ARG A CG  1 
ATOM   1498 C CD  . ARG A 1 218 ? 116.04384 -24.41803 3.43136   1.000 36.30458  ? 217 ARG A CD  1 
ATOM   1499 N NE  . ARG A 1 218 ? 116.46762 -25.19428 4.59223   1.000 36.03568  ? 217 ARG A NE  1 
ATOM   1500 C CZ  . ARG A 1 218 ? 116.01708 -24.99515 5.82369   1.000 38.34183  ? 217 ARG A CZ  1 
ATOM   1501 N NH1 . ARG A 1 218 ? 115.15228 -24.02893 6.09507   1.000 35.76594  ? 217 ARG A NH1 1 
ATOM   1502 N NH2 . ARG A 1 218 ? 116.45338 -25.77634 6.80902   1.000 34.24649  ? 217 ARG A NH2 1 
ATOM   1503 N N   . TYR A 1 219 ? 121.39369 -22.41119 3.56706   1.000 27.54376  ? 218 TYR A N   1 
ATOM   1504 C CA  . TYR A 1 219 ? 122.74394 -22.94504 3.67239   1.000 24.49182  ? 218 TYR A CA  1 
ATOM   1505 C C   . TYR A 1 219 ? 123.17564 -22.89107 5.13168   1.000 25.28434  ? 218 TYR A C   1 
ATOM   1506 O O   . TYR A 1 219 ? 122.58977 -22.18014 5.94856   1.000 26.73785  ? 218 TYR A O   1 
ATOM   1507 C CB  . TYR A 1 219 ? 123.74184 -22.17429 2.78775   1.000 22.60922  ? 218 TYR A CB  1 
ATOM   1508 C CG  . TYR A 1 219 ? 123.81148 -20.69536 3.12193   1.000 25.46694  ? 218 TYR A CG  1 
ATOM   1509 C CD1 . TYR A 1 219 ? 122.86455 -19.80646 2.62084   1.000 26.20094  ? 218 TYR A CD1 1 
ATOM   1510 C CD2 . TYR A 1 219 ? 124.81715 -20.18844 3.94009   1.000 25.69459  ? 218 TYR A CD2 1 
ATOM   1511 C CE1 . TYR A 1 219 ? 122.90977 -18.45851 2.93117   1.000 27.23226  ? 218 TYR A CE1 1 
ATOM   1512 C CE2 . TYR A 1 219 ? 124.85986 -18.84453 4.27165   1.000 23.12917  ? 218 TYR A CE2 1 
ATOM   1513 C CZ  . TYR A 1 219 ? 123.90747 -17.98427 3.76566   1.000 26.26722  ? 218 TYR A CZ  1 
ATOM   1514 O OH  . TYR A 1 219 ? 123.96315 -16.64121 4.08168   1.000 26.77401  ? 218 TYR A OH  1 
ATOM   1515 N N   . HIS A 1 220 ? 124.21297 -23.65477 5.44311   1.000 25.82621  ? 219 HIS A N   1 
ATOM   1516 C CA  . HIS A 1 220 ? 124.86933 -23.57779 6.73479   1.000 26.03810  ? 219 HIS A CA  1 
ATOM   1517 C C   . HIS A 1 220 ? 126.23119 -22.92167 6.54489   1.000 26.80778  ? 219 HIS A C   1 
ATOM   1518 O O   . HIS A 1 220 ? 126.81002 -22.96424 5.45807   1.000 22.66870  ? 219 HIS A O   1 
ATOM   1519 C CB  . HIS A 1 220 ? 124.97155 -24.96317 7.37734   1.000 26.06338  ? 219 HIS A CB  1 
ATOM   1520 C CG  . HIS A 1 220 ? 123.64894 -25.47170 7.86835   1.000 27.31867  ? 219 HIS A CG  1 
ATOM   1521 N ND1 . HIS A 1 220 ? 122.70166 -26.00848 7.02307   1.000 27.04618  ? 219 HIS A ND1 1 
ATOM   1522 C CD2 . HIS A 1 220 ? 123.08403 -25.45052 9.09936   1.000 28.91791  ? 219 HIS A CD2 1 
ATOM   1523 C CE1 . HIS A 1 220 ? 121.62471 -26.33442 7.71827   1.000 27.96193  ? 219 HIS A CE1 1 
ATOM   1524 N NE2 . HIS A 1 220 ? 121.83032 -26.00238 8.98064   1.000 31.57432  ? 219 HIS A NE2 1 
ATOM   1525 N N   . GLY A 1 221 ? 126.71729 -22.26982 7.60080   1.000 24.78245  ? 220 GLY A N   1 
ATOM   1526 C CA  . GLY A 1 221 ? 127.80477 -21.31732 7.41841   1.000 24.40980  ? 220 GLY A CA  1 
ATOM   1527 C C   . GLY A 1 221 ? 129.10293 -21.95839 6.96723   1.000 24.92086  ? 220 GLY A C   1 
ATOM   1528 O O   . GLY A 1 221 ? 129.71879 -21.51651 5.99273   1.000 22.41002  ? 220 GLY A O   1 
ATOM   1529 N N   . ARG A 1 222 ? 129.55461 -22.98748 7.68539   1.000 23.13820  ? 221 ARG A N   1 
ATOM   1530 C CA  . ARG A 1 222 ? 130.86893 -23.54925 7.39555   1.000 24.21354  ? 221 ARG A CA  1 
ATOM   1531 C C   . ARG A 1 222 ? 130.88884 -24.26622 6.05451   1.000 22.77295  ? 221 ARG A C   1 
ATOM   1532 O O   . ARG A 1 222 ? 131.84652 -24.11988 5.28138   1.000 21.64959  ? 221 ARG A O   1 
ATOM   1533 C CB  . ARG A 1 222 ? 131.29735 -24.48693 8.52286   1.000 27.96874  ? 221 ARG A CB  1 
ATOM   1534 C CG  . ARG A 1 222 ? 131.47242 -23.77001 9.86778   1.000 37.20404  ? 221 ARG A CG  1 
ATOM   1535 C CD  . ARG A 1 222 ? 131.50801 -24.75913 11.03208  1.000 44.45448  ? 221 ARG A CD  1 
ATOM   1536 N NE  . ARG A 1 222 ? 131.47113 -24.09949 12.33504  1.000 48.60794  ? 221 ARG A NE  1 
ATOM   1537 C CZ  . ARG A 1 222 ? 130.36527 -23.86808 13.03202  1.000 48.26596  ? 221 ARG A CZ  1 
ATOM   1538 N NH1 . ARG A 1 222 ? 129.16738 -24.19005 12.56201  1.000 49.68841  ? 221 ARG A NH1 1 
ATOM   1539 N NH2 . ARG A 1 222 ? 130.46335 -23.31876 14.24266  1.000 59.47370  ? 221 ARG A NH2 1 
ATOM   1540 N N   . SER A 1 223 ? 129.85067 -25.04933 5.74815   1.000 22.16171  ? 222 SER A N   1 
ATOM   1541 C CA  . SER A 1 223 ? 129.88038 -25.76590 4.47619   1.000 21.10737  ? 222 SER A CA  1 
ATOM   1542 C C   . SER A 1 223 ? 129.71089 -24.81882 3.29120   1.000 20.72802  ? 222 SER A C   1 
ATOM   1543 O O   . SER A 1 223 ? 130.26465 -25.07828 2.21586   1.000 21.04446  ? 222 SER A O   1 
ATOM   1544 C CB  . SER A 1 223 ? 128.82327 -26.87675 4.45747   1.000 24.89158  ? 222 SER A CB  1 
ATOM   1545 O OG  . SER A 1 223 ? 127.53427 -26.38511 4.75891   1.000 24.58813  ? 222 SER A OG  1 
ATOM   1546 N N   . ALA A 1 224 ? 128.98445 -23.70865 3.46098   1.000 20.62853  ? 223 ALA A N   1 
ATOM   1547 C CA  . ALA A 1 224 ? 128.92869 -22.70865 2.39487   1.000 20.78865  ? 223 ALA A CA  1 
ATOM   1548 C C   . ALA A 1 224 ? 130.27625 -22.01532 2.22672   1.000 23.10330  ? 223 ALA A C   1 
ATOM   1549 O O   . ALA A 1 224 ? 130.69586 -21.71306 1.09819   1.000 19.11912  ? 223 ALA A O   1 
ATOM   1550 C CB  . ALA A 1 224 ? 127.83332 -21.67684 2.68060   1.000 21.65608  ? 223 ALA A CB  1 
ATOM   1551 N N   . ALA A 1 225 ? 130.97076 -21.75919 3.33923   1.000 20.91905  ? 224 ALA A N   1 
ATOM   1552 C CA  . ALA A 1 225 ? 132.30166 -21.17037 3.24787   1.000 21.49041  ? 224 ALA A CA  1 
ATOM   1553 C C   . ALA A 1 225 ? 133.24463 -22.08566 2.48102   1.000 19.94495  ? 224 ALA A C   1 
ATOM   1554 O O   . ALA A 1 225 ? 134.01866 -21.62213 1.63781   1.000 19.18606  ? 224 ALA A O   1 
ATOM   1555 C CB  . ALA A 1 225 ? 132.84849 -20.86852 4.64590   1.000 22.86911  ? 224 ALA A CB  1 
ATOM   1556 N N   . VAL A 1 226 ? 133.17965 -23.39274 2.74749   1.000 18.62148  ? 225 VAL A N   1 
ATOM   1557 C CA  . VAL A 1 226 ? 134.06954 -24.33380 2.07323   1.000 19.60755  ? 225 VAL A CA  1 
ATOM   1558 C C   . VAL A 1 226 ? 133.77488 -24.37891 0.57356   1.000 18.35492  ? 225 VAL A C   1 
ATOM   1559 O O   . VAL A 1 226 ? 134.69957 -24.45997 -0.25086  1.000 18.22894  ? 225 VAL A O   1 
ATOM   1560 C CB  . VAL A 1 226 ? 133.96067 -25.72457 2.73037   1.000 20.57939  ? 225 VAL A CB  1 
ATOM   1561 C CG1 . VAL A 1 226 ? 134.61890 -26.80331 1.85764   1.000 18.62428  ? 225 VAL A CG1 1 
ATOM   1562 C CG2 . VAL A 1 226 ? 134.62063 -25.69062 4.11766   1.000 21.07537  ? 225 VAL A CG2 1 
ATOM   1563 N N   . TRP A 1 227 ? 132.49448 -24.31017 0.18949   1.000 18.56185  ? 226 TRP A N   1 
ATOM   1564 C CA  . TRP A 1 227 ? 132.17104 -24.20340 -1.23438  1.000 20.84596  ? 226 TRP A CA  1 
ATOM   1565 C C   . TRP A 1 227 ? 132.85419 -22.98944 -1.85986  1.000 20.93241  ? 226 TRP A C   1 
ATOM   1566 O O   . TRP A 1 227 ? 133.48147 -23.09452 -2.91809  1.000 19.37499  ? 226 TRP A O   1 
ATOM   1567 C CB  . TRP A 1 227 ? 130.65044 -24.14207 -1.44850  1.000 19.38447  ? 226 TRP A CB  1 
ATOM   1568 C CG  . TRP A 1 227 ? 130.30728 -23.94801 -2.89316  1.000 22.91029  ? 226 TRP A CG  1 
ATOM   1569 C CD1 . TRP A 1 227 ? 130.32336 -22.76745 -3.59052  1.000 22.54435  ? 226 TRP A CD1 1 
ATOM   1570 C CD2 . TRP A 1 227 ? 129.93314 -24.96540 -3.83807  1.000 19.61386  ? 226 TRP A CD2 1 
ATOM   1571 N NE1 . TRP A 1 227 ? 129.97501 -22.98685 -4.90155  1.000 19.16037  ? 226 TRP A NE1 1 
ATOM   1572 C CE2 . TRP A 1 227 ? 129.72885 -24.32400 -5.08217  1.000 21.08564  ? 226 TRP A CE2 1 
ATOM   1573 C CE3 . TRP A 1 227 ? 129.75104 -26.35325 -3.75278  1.000 23.80960  ? 226 TRP A CE3 1 
ATOM   1574 C CZ2 . TRP A 1 227 ? 129.34823 -25.02001 -6.23580  1.000 21.51933  ? 226 TRP A CZ2 1 
ATOM   1575 C CZ3 . TRP A 1 227 ? 129.36327 -27.04632 -4.89983  1.000 23.04007  ? 226 TRP A CZ3 1 
ATOM   1576 C CH2 . TRP A 1 227 ? 129.16725 -26.37471 -6.12573  1.000 24.07580  ? 226 TRP A CH2 1 
ATOM   1577 N N   . SER A 1 228 ? 132.73783 -21.81627 -1.22854  1.000 18.18239  ? 227 SER A N   1 
ATOM   1578 C CA  . SER A 1 228 ? 133.36648 -20.62890 -1.80881  1.000 19.39068  ? 227 SER A CA  1 
ATOM   1579 C C   . SER A 1 228 ? 134.88098 -20.77980 -1.88774  1.000 19.01327  ? 227 SER A C   1 
ATOM   1580 O O   . SER A 1 228 ? 135.51568 -20.22585 -2.79653  1.000 17.62310  ? 227 SER A O   1 
ATOM   1581 C CB  . SER A 1 228 ? 132.99966 -19.37232 -1.00246  1.000 19.60747  ? 227 SER A CB  1 
ATOM   1582 O OG  . SER A 1 228 ? 133.65805 -19.32285 0.27884   1.000 20.83457  ? 227 SER A OG  1 
ATOM   1583 N N   . LEU A 1 229 ? 135.47327 -21.51962 -0.94885  1.000 17.76287  ? 228 LEU A N   1 
ATOM   1584 C CA  . LEU A 1 229 ? 136.91369 -21.76245 -0.98136  1.000 16.87632  ? 228 LEU A CA  1 
ATOM   1585 C C   . LEU A 1 229 ? 137.29830 -22.68414 -2.13697  1.000 16.81080  ? 228 LEU A C   1 
ATOM   1586 O O   . LEU A 1 229 ? 138.36602 -22.52132 -2.73372  1.000 17.75351  ? 228 LEU A O   1 
ATOM   1587 C CB  . LEU A 1 229 ? 137.36553 -22.35246 0.35851   1.000 18.14506  ? 228 LEU A CB  1 
ATOM   1588 C CG  . LEU A 1 229 ? 137.31423 -21.36643 1.53908   1.000 18.35118  ? 228 LEU A CG  1 
ATOM   1589 C CD1 . LEU A 1 229 ? 137.42526 -22.10869 2.86197   1.000 20.01067  ? 228 LEU A CD1 1 
ATOM   1590 C CD2 . LEU A 1 229 ? 138.40771 -20.28601 1.40893   1.000 18.84437  ? 228 LEU A CD2 1 
ATOM   1591 N N   . GLY A 1 230 ? 136.45436 -23.66455 -2.46207  1.000 17.75513  ? 229 GLY A N   1 
ATOM   1592 C CA  . GLY A 1 230 ? 136.68983 -24.44664 -3.67329  1.000 21.00753  ? 229 GLY A CA  1 
ATOM   1593 C C   . GLY A 1 230 ? 136.64809 -23.60310 -4.93738  1.000 19.68760  ? 229 GLY A C   1 
ATOM   1594 O O   . GLY A 1 230 ? 137.47409 -23.77564 -5.84518  1.000 17.68822  ? 229 GLY A O   1 
ATOM   1595 N N   . ILE A 1 231 ? 135.66914 -22.69827 -5.02628  1.000 16.53919  ? 230 ILE A N   1 
ATOM   1596 C CA  . ILE A 1 231 ? 135.61081 -21.76685 -6.15140  1.000 18.43688  ? 230 ILE A CA  1 
ATOM   1597 C C   . ILE A 1 231 ? 136.89227 -20.94987 -6.20891  1.000 19.48855  ? 230 ILE A C   1 
ATOM   1598 O O   . ILE A 1 231 ? 137.50711 -20.79403 -7.27022  1.000 18.74351  ? 230 ILE A O   1 
ATOM   1599 C CB  . ILE A 1 231 ? 134.37784 -20.85037 -6.02936  1.000 18.31413  ? 230 ILE A CB  1 
ATOM   1600 C CG1 . ILE A 1 231 ? 133.08456 -21.67726 -5.95165  1.000 19.64604  ? 230 ILE A CG1 1 
ATOM   1601 C CG2 . ILE A 1 231 ? 134.33945 -19.81066 -7.20494  1.000 19.36815  ? 230 ILE A CG2 1 
ATOM   1602 C CD1 . ILE A 1 231 ? 132.74153 -22.46141 -7.25613  1.000 17.96240  ? 230 ILE A CD1 1 
ATOM   1603 N N   . LEU A 1 232 ? 137.32671 -20.44242 -5.04775  1.000 17.46388  ? 231 LEU A N   1 
ATOM   1604 C CA  . LEU A 1 232 ? 138.53760 -19.62999 -4.98900  1.000 17.33739  ? 231 LEU A CA  1 
ATOM   1605 C C   . LEU A 1 232 ? 139.76589 -20.41823 -5.43573  1.000 18.11997  ? 231 LEU A C   1 
ATOM   1606 O O   . LEU A 1 232 ? 140.64498 -19.87917 -6.11129  1.000 18.80885  ? 231 LEU A O   1 
ATOM   1607 C CB  . LEU A 1 232 ? 138.74713 -19.11816 -3.56003  1.000 15.45337  ? 231 LEU A CB  1 
ATOM   1608 C CG  . LEU A 1 232 ? 140.03013 -18.29914 -3.36552  1.000 18.73708  ? 231 LEU A CG  1 
ATOM   1609 C CD1 . LEU A 1 232 ? 140.01845 -17.00565 -4.19054  1.000 18.22668  ? 231 LEU A CD1 1 
ATOM   1610 C CD2 . LEU A 1 232 ? 140.26841 -17.99863 -1.86316  1.000 17.04631  ? 231 LEU A CD2 1 
ATOM   1611 N N   . LEU A 1 233 ? 139.88608 -21.67031 -4.98951  1.000 17.04069  ? 232 LEU A N   1 
ATOM   1612 C CA  . LEU A 1 233 ? 141.07416 -22.44517 -5.33333  1.000 16.97323  ? 232 LEU A CA  1 
ATOM   1613 C C   . LEU A 1 233 ? 141.10770 -22.74956 -6.83278  1.000 17.91287  ? 232 LEU A C   1 
ATOM   1614 O O   . LEU A 1 233 ? 142.15991 -22.63311 -7.47583  1.000 18.79668  ? 232 LEU A O   1 
ATOM   1615 C CB  . LEU A 1 233 ? 141.11413 -23.73287 -4.50348  1.000 16.00867  ? 232 LEU A CB  1 
ATOM   1616 C CG  . LEU A 1 233 ? 142.30660 -24.66504 -4.77570  1.000 19.62543  ? 232 LEU A CG  1 
ATOM   1617 C CD1 . LEU A 1 233 ? 143.65871 -23.91792 -4.63770  1.000 19.73768  ? 232 LEU A CD1 1 
ATOM   1618 C CD2 . LEU A 1 233 ? 142.25486 -25.88817 -3.84934  1.000 19.31141  ? 232 LEU A CD2 1 
ATOM   1619 N N   . TYR A 1 234 ? 139.97070 -23.13898 -7.40617  1.000 16.03515  ? 233 TYR A N   1 
ATOM   1620 C CA  . TYR A 1 234 ? 139.89692 -23.29834 -8.86021  1.000 16.70910  ? 233 TYR A CA  1 
ATOM   1621 C C   . TYR A 1 234 ? 140.33558 -22.01471 -9.55893  1.000 21.31534  ? 233 TYR A C   1 
ATOM   1622 O O   . TYR A 1 234 ? 141.12388 -22.03305 -10.51559 1.000 19.56320  ? 233 TYR A O   1 
ATOM   1623 C CB  . TYR A 1 234 ? 138.46418 -23.65915 -9.27281  1.000 16.91696  ? 233 TYR A CB  1 
ATOM   1624 C CG  . TYR A 1 234 ? 138.33244 -23.96656 -10.75028 1.000 20.60659  ? 233 TYR A CG  1 
ATOM   1625 C CD1 . TYR A 1 234 ? 138.27264 -22.93728 -11.69345 1.000 17.49436  ? 233 TYR A CD1 1 
ATOM   1626 C CD2 . TYR A 1 234 ? 138.27085 -25.27748 -11.20790 1.000 17.85300  ? 233 TYR A CD2 1 
ATOM   1627 C CE1 . TYR A 1 234 ? 138.16592 -23.19636 -13.04511 1.000 20.76713  ? 233 TYR A CE1 1 
ATOM   1628 C CE2 . TYR A 1 234 ? 138.15498 -25.54749 -12.59091 1.000 19.14942  ? 233 TYR A CE2 1 
ATOM   1629 C CZ  . TYR A 1 234 ? 138.11386 -24.49131 -13.49117 1.000 22.11628  ? 233 TYR A CZ  1 
ATOM   1630 O OH  . TYR A 1 234 ? 138.00987 -24.72233 -14.84972 1.000 22.47618  ? 233 TYR A OH  1 
ATOM   1631 N N   . ASP A 1 235 ? 139.80299 -20.88665 -9.09436  1.000 18.38234  ? 234 ASP A N   1 
ATOM   1632 C CA  . ASP A 1 235 ? 140.14678 -19.57816 -9.64359  1.000 17.37640  ? 234 ASP A CA  1 
ATOM   1633 C C   . ASP A 1 235 ? 141.65894 -19.36960 -9.66206  1.000 18.63294  ? 234 ASP A C   1 
ATOM   1634 O O   . ASP A 1 235 ? 142.22598 -18.91754 -10.66699 1.000 18.83711  ? 234 ASP A O   1 
ATOM   1635 C CB  . ASP A 1 235 ? 139.42146 -18.51443 -8.79191  1.000 18.29208  ? 234 ASP A CB  1 
ATOM   1636 C CG  . ASP A 1 235 ? 139.71070 -17.08026 -9.20554  1.000 22.69614  ? 234 ASP A CG  1 
ATOM   1637 O OD1 . ASP A 1 235 ? 139.62258 -16.72253 -10.40484 1.000 21.80735  ? 234 ASP A OD1 1 
ATOM   1638 O OD2 . ASP A 1 235 ? 139.98600 -16.27729 -8.28453  1.000 20.26916  ? 234 ASP A OD2 1 
ATOM   1639 N N   A MET A 1 236 ? 142.34593 -19.73927 -8.57793  0.493 17.55268  ? 235 MET A N   1 
ATOM   1640 N N   B MET A 1 236 ? 142.32708 -19.67456 -8.54367  0.507 17.53964  ? 235 MET A N   1 
ATOM   1641 C CA  A MET A 1 236 ? 143.78050 -19.47952 -8.50786  0.493 17.48868  ? 235 MET A CA  1 
ATOM   1642 C CA  B MET A 1 236 ? 143.77682 -19.52765 -8.47099  0.507 17.49295  ? 235 MET A CA  1 
ATOM   1643 C C   A MET A 1 236 ? 144.57845 -20.39682 -9.43038  0.493 19.08180  ? 235 MET A C   1 
ATOM   1644 C C   B MET A 1 236 ? 144.46499 -20.36307 -9.54095  0.507 19.12697  ? 235 MET A C   1 
ATOM   1645 O O   A MET A 1 236 ? 145.57192 -19.96596 -10.02245 0.493 20.82555  ? 235 MET A O   1 
ATOM   1646 O O   B MET A 1 236 ? 145.23885 -19.84731 -10.35376 0.507 21.48901  ? 235 MET A O   1 
ATOM   1647 C CB  A MET A 1 236 ? 144.27871 -19.61204 -7.06941  0.493 18.62145  ? 235 MET A CB  1 
ATOM   1648 C CB  B MET A 1 236 ? 144.28951 -19.93365 -7.08355  0.507 17.91547  ? 235 MET A CB  1 
ATOM   1649 C CG  A MET A 1 236 ? 143.96276 -18.38775 -6.20513  0.493 17.14026  ? 235 MET A CG  1 
ATOM   1650 C CG  B MET A 1 236 ? 143.81867 -19.04015 -5.93836  0.507 19.63960  ? 235 MET A CG  1 
ATOM   1651 S SD  A MET A 1 236 ? 144.86945 -18.46088 -4.66141  0.493 19.27930  ? 235 MET A SD  1 
ATOM   1652 S SD  B MET A 1 236 ? 144.57021 -19.58164 -4.38827  0.507 20.08461  ? 235 MET A SD  1 
ATOM   1653 C CE  A MET A 1 236 ? 143.99474 -19.80937 -3.85710  0.493 17.50087  ? 235 MET A CE  1 
ATOM   1654 C CE  B MET A 1 236 ? 143.86800 -18.38621 -3.25190  0.507 16.94393  ? 235 MET A CE  1 
ATOM   1655 N N   . VAL A 1 237 ? 144.18601 -21.66783 -9.55770  1.000 18.32688  ? 236 VAL A N   1 
ATOM   1656 C CA  . VAL A 1 237 ? 144.98575 -22.58073 -10.37570 1.000 18.00370  ? 236 VAL A CA  1 
ATOM   1657 C C   . VAL A 1 237 ? 144.54690 -22.64276 -11.82936 1.000 22.03016  ? 236 VAL A C   1 
ATOM   1658 O O   . VAL A 1 237 ? 145.30740 -23.15867 -12.66307 1.000 23.09348  ? 236 VAL A O   1 
ATOM   1659 C CB  . VAL A 1 237 ? 145.02088 -24.01498 -9.80574  1.000 18.60345  ? 236 VAL A CB  1 
ATOM   1660 C CG1 . VAL A 1 237 ? 145.65175 -24.00792 -8.39379  1.000 19.34390  ? 236 VAL A CG1 1 
ATOM   1661 C CG2 . VAL A 1 237 ? 143.62849 -24.64124 -9.78394  1.000 20.42939  ? 236 VAL A CG2 1 
ATOM   1662 N N   . CYS A 1 238 ? 143.36090 -22.12908 -12.17135 1.000 20.41690  ? 237 CYS A N   1 
ATOM   1663 C CA  . CYS A 1 238 ? 142.90574 -22.10546 -13.55882 1.000 23.44337  ? 237 CYS A CA  1 
ATOM   1664 C C   . CYS A 1 238 ? 142.83423 -20.70956 -14.16588 1.000 23.84383  ? 237 CYS A C   1 
ATOM   1665 O O   . CYS A 1 238 ? 142.69748 -20.59673 -15.39069 1.000 22.45873  ? 237 CYS A O   1 
ATOM   1666 C CB  . CYS A 1 238 ? 141.53005 -22.77202 -13.68797 1.000 21.37890  ? 237 CYS A CB  1 
ATOM   1667 S SG  . CYS A 1 238 ? 141.61886 -24.57280 -13.49174 1.000 25.13657  ? 237 CYS A SG  1 
ATOM   1668 N N   . GLY A 1 239 ? 142.92319 -19.64964 -13.35921 1.000 20.97240  ? 238 GLY A N   1 
ATOM   1669 C CA  . GLY A 1 239 ? 142.91759 -18.29542 -13.87520 1.000 21.60218  ? 238 GLY A CA  1 
ATOM   1670 C C   . GLY A 1 239 ? 141.55650 -17.64004 -13.94803 1.000 25.01214  ? 238 GLY A C   1 
ATOM   1671 O O   . GLY A 1 239 ? 141.47566 -16.44622 -14.25979 1.000 24.26475  ? 238 GLY A O   1 
ATOM   1672 N N   . ASP A 1 240 ? 140.48357 -18.37777 -13.69150 1.000 20.33964  ? 239 ASP A N   1 
ATOM   1673 C CA  . ASP A 1 240 ? 139.16558 -17.77782 -13.53681 1.000 22.04396  ? 239 ASP A CA  1 
ATOM   1674 C C   . ASP A 1 240 ? 138.29081 -18.79295 -12.81346 1.000 24.32312  ? 239 ASP A C   1 
ATOM   1675 O O   . ASP A 1 240 ? 138.65466 -19.96257 -12.68085 1.000 21.79891  ? 239 ASP A O   1 
ATOM   1676 C CB  . ASP A 1 240 ? 138.56979 -17.37204 -14.88926 1.000 24.16630  ? 239 ASP A CB  1 
ATOM   1677 C CG  . ASP A 1 240 ? 137.46649 -16.34504 -14.75719 1.000 27.17829  ? 239 ASP A CG  1 
ATOM   1678 O OD1 . ASP A 1 240 ? 137.23804 -15.84422 -13.63252 1.000 23.69423  ? 239 ASP A OD1 1 
ATOM   1679 O OD2 . ASP A 1 240 ? 136.82956 -16.04074 -15.78815 1.000 30.66182  ? 239 ASP A OD2 1 
ATOM   1680 N N   . ILE A 1 241 ? 137.14055 -18.33068 -12.33375 1.000 18.93392  ? 240 ILE A N   1 
ATOM   1681 C CA  . ILE A 1 241 ? 136.20784 -19.17211 -11.58128 1.000 19.40896  ? 240 ILE A CA  1 
ATOM   1682 C C   . ILE A 1 241 ? 135.57479 -20.20559 -12.50692 1.000 19.70126  ? 240 ILE A C   1 
ATOM   1683 O O   . ILE A 1 241 ? 135.50143 -19.98452 -13.72565 1.000 21.25834  ? 240 ILE A O   1 
ATOM   1684 C CB  . ILE A 1 241 ? 135.12630 -18.31904 -10.91083 1.000 23.40156  ? 240 ILE A CB  1 
ATOM   1685 C CG1 . ILE A 1 241 ? 134.32521 -17.56221 -11.97153 1.000 21.70414  ? 240 ILE A CG1 1 
ATOM   1686 C CG2 . ILE A 1 241 ? 135.75725 -17.37097 -9.89194  1.000 20.72993  ? 240 ILE A CG2 1 
ATOM   1687 C CD1 . ILE A 1 241 ? 133.21135 -16.71812 -11.34582 1.000 26.05489  ? 240 ILE A CD1 1 
ATOM   1688 N N   . PRO A 1 242 ? 135.10175 -21.33717 -11.98316 1.000 20.48002  ? 241 PRO A N   1 
ATOM   1689 C CA  . PRO A 1 242 ? 134.59294 -22.39060 -12.86587 1.000 21.29559  ? 241 PRO A CA  1 
ATOM   1690 C C   . PRO A 1 242 ? 133.17922 -22.13621 -13.36704 1.000 25.87685  ? 241 PRO A C   1 
ATOM   1691 O O   . PRO A 1 242 ? 132.84847 -22.54322 -14.48663 1.000 22.40486  ? 241 PRO A O   1 
ATOM   1692 C CB  . PRO A 1 242 ? 134.65820 -23.64619 -11.98450 1.000 18.85035  ? 241 PRO A CB  1 
ATOM   1693 C CG  . PRO A 1 242 ? 134.43558 -23.10547 -10.57605 1.000 19.97884  ? 241 PRO A CG  1 
ATOM   1694 C CD  . PRO A 1 242 ? 135.15284 -21.76405 -10.56819 1.000 20.12036  ? 241 PRO A CD  1 
ATOM   1695 N N   . PHE A 1 243 ? 132.34037 -21.45900 -12.58083 1.000 19.76948  ? 242 PHE A N   1 
ATOM   1696 C CA  . PHE A 1 243 ? 130.91315 -21.35336 -12.87416 1.000 20.83671  ? 242 PHE A CA  1 
ATOM   1697 C C   . PHE A 1 243 ? 130.51124 -19.89511 -13.04802 1.000 26.42430  ? 242 PHE A C   1 
ATOM   1698 O O   . PHE A 1 243 ? 130.87049 -19.04898 -12.22648 1.000 24.25662  ? 242 PHE A O   1 
ATOM   1699 C CB  . PHE A 1 243 ? 130.06447 -21.95502 -11.75268 1.000 22.18082  ? 242 PHE A CB  1 
ATOM   1700 C CG  . PHE A 1 243 ? 130.46690 -23.33871 -11.35013 1.000 25.16151  ? 242 PHE A CG  1 
ATOM   1701 C CD1 . PHE A 1 243 ? 130.77519 -24.29891 -12.30886 1.000 23.86926  ? 242 PHE A CD1 1 
ATOM   1702 C CD2 . PHE A 1 243 ? 130.54775 -23.67421 -10.00276 1.000 19.79533  ? 242 PHE A CD2 1 
ATOM   1703 C CE1 . PHE A 1 243 ? 131.14572 -25.58708 -11.92220 1.000 23.20645  ? 242 PHE A CE1 1 
ATOM   1704 C CE2 . PHE A 1 243 ? 130.90777 -24.96626 -9.60217  1.000 22.84575  ? 242 PHE A CE2 1 
ATOM   1705 C CZ  . PHE A 1 243 ? 131.20547 -25.91928 -10.56830 1.000 22.93170  ? 242 PHE A CZ  1 
ATOM   1706 N N   . GLU A 1 244 ? 129.72594 -19.60994 -14.09107 1.000 26.93969  ? 243 GLU A N   1 
ATOM   1707 C CA  . GLU A 1 244 ? 129.11355 -18.29450 -14.23824 1.000 24.80541  ? 243 GLU A CA  1 
ATOM   1708 C C   . GLU A 1 244 ? 127.59745 -18.31272 -14.11801 1.000 31.06044  ? 243 GLU A C   1 
ATOM   1709 O O   . GLU A 1 244 ? 127.00929 -17.26006 -13.86603 1.000 38.21427  ? 243 GLU A O   1 
ATOM   1710 C CB  . GLU A 1 244 ? 129.48249 -17.66397 -15.59474 1.000 27.78758  ? 243 GLU A CB  1 
ATOM   1711 C CG  . GLU A 1 244 ? 130.96018 -17.29235 -15.75222 1.000 33.89898  ? 243 GLU A CG  1 
ATOM   1712 C CD  . GLU A 1 244 ? 131.36612 -16.06967 -14.93802 1.000 36.00732  ? 243 GLU A CD  1 
ATOM   1713 O OE1 . GLU A 1 244 ? 130.48086 -15.29730 -14.50210 1.000 28.72996  ? 243 GLU A OE1 1 
ATOM   1714 O OE2 . GLU A 1 244 ? 132.58535 -15.88573 -14.72895 1.000 36.68005  ? 243 GLU A OE2 1 
ATOM   1715 N N   . HIS A 1 245 ? 126.95473 -19.46839 -14.29205 1.000 30.44612  ? 244 HIS A N   1 
ATOM   1716 C CA  . HIS A 1 245 ? 125.50412 -19.55923 -14.36260 1.000 27.58355  ? 244 HIS A CA  1 
ATOM   1717 C C   . HIS A 1 245 ? 124.97088 -20.51146 -13.29975 1.000 28.86082  ? 244 HIS A C   1 
ATOM   1718 O O   . HIS A 1 245 ? 125.65552 -21.45616 -12.89415 1.000 26.95762  ? 244 HIS A O   1 
ATOM   1719 C CB  . HIS A 1 245 ? 125.06372 -20.03183 -15.75592 1.000 30.81734  ? 244 HIS A CB  1 
ATOM   1720 C CG  . HIS A 1 245 ? 125.65669 -19.22802 -16.86715 1.000 36.51036  ? 244 HIS A CG  1 
ATOM   1721 N ND1 . HIS A 1 245 ? 125.16247 -17.99562 -17.23769 1.000 44.34807  ? 244 HIS A ND1 1 
ATOM   1722 C CD2 . HIS A 1 245 ? 126.71867 -19.46634 -17.67272 1.000 38.20987  ? 244 HIS A CD2 1 
ATOM   1723 C CE1 . HIS A 1 245 ? 125.88420 -17.51756 -18.23647 1.000 49.30754  ? 244 HIS A CE1 1 
ATOM   1724 N NE2 . HIS A 1 245 ? 126.83641 -18.38948 -18.51773 1.000 45.45136  ? 244 HIS A NE2 1 
ATOM   1725 N N   . ASP A 1 246 ? 123.72963 -20.25517 -12.86426 1.000 31.21719  ? 245 ASP A N   1 
ATOM   1726 C CA  . ASP A 1 246 ? 123.09435 -21.10249 -11.85508 1.000 31.43440  ? 245 ASP A CA  1 
ATOM   1727 C C   . ASP A 1 246 ? 123.13563 -22.56707 -12.25069 1.000 31.37547  ? 245 ASP A C   1 
ATOM   1728 O O   . ASP A 1 246 ? 123.40368 -23.43287 -11.41287 1.000 29.67648  ? 245 ASP A O   1 
ATOM   1729 C CB  . ASP A 1 246 ? 121.64533 -20.68100 -11.63534 1.000 34.43310  ? 245 ASP A CB  1 
ATOM   1730 C CG  . ASP A 1 246 ? 121.52739 -19.33487 -10.97854 1.000 32.85827  ? 245 ASP A CG  1 
ATOM   1731 O OD1 . ASP A 1 246 ? 122.56943 -18.75314 -10.61449 1.000 31.86101  ? 245 ASP A OD1 1 
ATOM   1732 O OD2 . ASP A 1 246 ? 120.38547 -18.86486 -10.81642 1.000 34.22512  ? 245 ASP A OD2 1 
ATOM   1733 N N   . GLU A 1 247 ? 122.86633 -22.86018 -13.52913 1.000 28.00536  ? 246 GLU A N   1 
ATOM   1734 C CA  . GLU A 1 247 ? 122.82964 -24.24305 -13.98590 1.000 27.24478  ? 246 GLU A CA  1 
ATOM   1735 C C   . GLU A 1 247 ? 124.18147 -24.92508 -13.81932 1.000 29.29209  ? 246 GLU A C   1 
ATOM   1736 O O   . GLU A 1 247 ? 124.23691 -26.13509 -13.56622 1.000 29.38321  ? 246 GLU A O   1 
ATOM   1737 C CB  . GLU A 1 247 ? 122.37089 -24.29679 -15.45235 1.000 34.72188  ? 246 GLU A CB  1 
ATOM   1738 C CG  . GLU A 1 247 ? 120.95258 -23.76467 -15.68559 1.000 43.89409  ? 246 GLU A CG  1 
ATOM   1739 C CD  . GLU A 1 247 ? 120.85800 -22.23379 -15.70090 1.000 55.09413  ? 246 GLU A CD  1 
ATOM   1740 O OE1 . GLU A 1 247 ? 121.89147 -21.53677 -15.55322 1.000 40.26322  ? 246 GLU A OE1 1 
ATOM   1741 N N   . GLU A 1 248 ? 125.27831 -24.17388 -13.96384 1.000 28.24038  ? 247 GLU A N   1 
ATOM   1742 C CA  . GLU A 1 248 ? 126.60508 -24.74601 -13.73511 1.000 28.77591  ? 247 GLU A CA  1 
ATOM   1743 C C   . GLU A 1 248 ? 126.86857 -24.96295 -12.24917 1.000 27.34114  ? 247 GLU A C   1 
ATOM   1744 O O   . GLU A 1 248 ? 127.48235 -25.96484 -11.85892 1.000 27.86038  ? 247 GLU A O   1 
ATOM   1745 C CB  . GLU A 1 248 ? 127.67754 -23.83577 -14.32834 1.000 29.66377  ? 247 GLU A CB  1 
ATOM   1746 C CG  . GLU A 1 248 ? 127.58536 -23.68648 -15.85367 1.000 32.03592  ? 247 GLU A CG  1 
ATOM   1747 C CD  . GLU A 1 248 ? 128.52764 -22.61660 -16.39246 1.000 35.78642  ? 247 GLU A CD  1 
ATOM   1748 O OE1 . GLU A 1 248 ? 128.73875 -21.60659 -15.70323 1.000 31.14830  ? 247 GLU A OE1 1 
ATOM   1749 O OE2 . GLU A 1 248 ? 129.05439 -22.78062 -17.50929 1.000 44.69011  ? 247 GLU A OE2 1 
ATOM   1750 N N   . ILE A 1 249 ? 126.44364 -24.01881 -11.40860 1.000 24.98181  ? 248 ILE A N   1 
ATOM   1751 C CA  . ILE A 1 249 ? 126.63838 -24.16951 -9.96294  1.000 23.58706  ? 248 ILE A CA  1 
ATOM   1752 C C   . ILE A 1 249 ? 125.96411 -25.43991 -9.46262  1.000 27.79841  ? 248 ILE A C   1 
ATOM   1753 O O   . ILE A 1 249 ? 126.54027 -26.20628 -8.67902  1.000 28.79600  ? 248 ILE A O   1 
ATOM   1754 C CB  . ILE A 1 249 ? 126.11445 -22.92957 -9.21187  1.000 23.37608  ? 248 ILE A CB  1 
ATOM   1755 C CG1 . ILE A 1 249 ? 126.89522 -21.68296 -9.62745  1.000 24.65308  ? 248 ILE A CG1 1 
ATOM   1756 C CG2 . ILE A 1 249 ? 126.16444 -23.16091 -7.68100  1.000 24.50086  ? 248 ILE A CG2 1 
ATOM   1757 C CD1 . ILE A 1 249 ? 126.29204 -20.38016 -9.11907  1.000 25.84834  ? 248 ILE A CD1 1 
ATOM   1758 N N   . ILE A 1 250 ? 124.72061 -25.67787 -9.88519  1.000 26.71023  ? 249 ILE A N   1 
ATOM   1759 C CA  . ILE A 1 250 ? 124.01643 -26.83448 -9.33654  1.000 27.22032  ? 249 ILE A CA  1 
ATOM   1760 C C   . ILE A 1 250 ? 124.33908 -28.11898 -10.08096 1.000 31.90261  ? 249 ILE A C   1 
ATOM   1761 O O   . ILE A 1 250 ? 124.02363 -29.20461 -9.57876  1.000 30.02005  ? 249 ILE A O   1 
ATOM   1762 C CB  . ILE A 1 250 ? 122.49435 -26.58932 -9.30258  1.000 34.69160  ? 249 ILE A CB  1 
ATOM   1763 C CG1 . ILE A 1 250 ? 121.91866 -26.49697 -10.71258 1.000 30.40287  ? 249 ILE A CG1 1 
ATOM   1764 C CG2 . ILE A 1 250 ? 122.18227 -25.32285 -8.50646  1.000 33.01212  ? 249 ILE A CG2 1 
ATOM   1765 C CD1 . ILE A 1 250 ? 120.40647 -26.37040 -10.74737 1.000 36.84284  ? 249 ILE A CD1 1 
ATOM   1766 N N   . GLY A 1 251 ? 124.99870 -28.03229 -11.24063 1.000 25.63535  ? 250 GLY A N   1 
ATOM   1767 C CA  . GLY A 1 251 ? 125.20079 -29.21576 -12.06382 1.000 30.68103  ? 250 GLY A CA  1 
ATOM   1768 C C   . GLY A 1 251 ? 126.22406 -30.19032 -11.50957 1.000 36.79353  ? 250 GLY A C   1 
ATOM   1769 O O   . GLY A 1 251 ? 126.16037 -31.39138 -11.79220 1.000 46.85207  ? 250 GLY A O   1 
ATOM   1770 N N   . GLY A 1 252 ? 127.18249 -29.70141 -10.73756 1.000 32.18076  ? 251 GLY A N   1 
ATOM   1771 C CA  . GLY A 1 252 ? 128.13849 -30.59900 -10.12268 1.000 48.02001  ? 251 GLY A CA  1 
ATOM   1772 C C   . GLY A 1 252 ? 129.25554 -31.09191 -11.01538 1.000 51.65559  ? 251 GLY A C   1 
ATOM   1773 O O   . GLY A 1 252 ? 129.85337 -32.12910 -10.71498 1.000 49.72026  ? 251 GLY A O   1 
ATOM   1774 N N   . GLN A 1 253 ? 129.57234 -30.39114 -12.10222 1.000 35.93587  ? 252 GLN A N   1 
ATOM   1775 C CA  . GLN A 1 253 ? 130.62312 -30.84109 -13.00736 1.000 31.23078  ? 252 GLN A CA  1 
ATOM   1776 C C   . GLN A 1 253 ? 131.73072 -29.79789 -13.06188 1.000 28.66540  ? 252 GLN A C   1 
ATOM   1777 O O   . GLN A 1 253 ? 131.50022 -28.64771 -13.44772 1.000 32.03803  ? 252 GLN A O   1 
ATOM   1778 C CB  . GLN A 1 253 ? 130.06195 -31.13386 -14.39685 1.000 35.93227  ? 252 GLN A CB  1 
ATOM   1779 C CG  . GLN A 1 253 ? 129.09507 -32.32955 -14.39574 1.000 45.54303  ? 252 GLN A CG  1 
ATOM   1780 C CD  . GLN A 1 253 ? 129.03262 -33.03932 -15.73612 1.000 51.89954  ? 252 GLN A CD  1 
ATOM   1781 N N   . VAL A 1 254 ? 132.93411 -30.20555 -12.69271 1.000 23.50056  ? 253 VAL A N   1 
ATOM   1782 C CA  . VAL A 1 254 ? 134.07927 -29.30825 -12.66021 1.000 20.70325  ? 253 VAL A CA  1 
ATOM   1783 C C   . VAL A 1 254 ? 134.99509 -29.70032 -13.81558 1.000 26.80949  ? 253 VAL A C   1 
ATOM   1784 O O   . VAL A 1 254 ? 135.66417 -30.74007 -13.76733 1.000 27.82526  ? 253 VAL A O   1 
ATOM   1785 C CB  . VAL A 1 254 ? 134.80806 -29.37354 -11.31358 1.000 21.28506  ? 253 VAL A CB  1 
ATOM   1786 C CG1 . VAL A 1 254 ? 135.99104 -28.39671 -11.29059 1.000 24.00346  ? 253 VAL A CG1 1 
ATOM   1787 C CG2 . VAL A 1 254 ? 133.81754 -29.06587 -10.14478 1.000 26.31621  ? 253 VAL A CG2 1 
ATOM   1788 N N   . PHE A 1 255 ? 135.02281 -28.87309 -14.85314 1.000 23.01904  ? 254 PHE A N   1 
ATOM   1789 C CA  . PHE A 1 255 ? 135.94708 -29.04227 -15.97608 1.000 22.24243  ? 254 PHE A CA  1 
ATOM   1790 C C   . PHE A 1 255 ? 137.19368 -28.20446 -15.71575 1.000 23.64211  ? 254 PHE A C   1 
ATOM   1791 O O   . PHE A 1 255 ? 137.08445 -27.02138 -15.38760 1.000 21.31988  ? 254 PHE A O   1 
ATOM   1792 C CB  . PHE A 1 255 ? 135.27213 -28.60642 -17.28061 1.000 22.44040  ? 254 PHE A CB  1 
ATOM   1793 C CG  . PHE A 1 255 ? 136.22158 -28.46633 -18.45065 1.000 26.32429  ? 254 PHE A CG  1 
ATOM   1794 C CD1 . PHE A 1 255 ? 136.54118 -29.56817 -19.23483 1.000 26.11230  ? 254 PHE A CD1 1 
ATOM   1795 C CD2 . PHE A 1 255 ? 136.79670 -27.22627 -18.76313 1.000 21.54511  ? 254 PHE A CD2 1 
ATOM   1796 C CE1 . PHE A 1 255 ? 137.41811 -29.44592 -20.33325 1.000 24.57249  ? 254 PHE A CE1 1 
ATOM   1797 C CE2 . PHE A 1 255 ? 137.67409 -27.09524 -19.83619 1.000 22.95704  ? 254 PHE A CE2 1 
ATOM   1798 C CZ  . PHE A 1 255 ? 137.98190 -28.20752 -20.62782 1.000 24.22773  ? 254 PHE A CZ  1 
ATOM   1799 N N   . PHE A 1 256 ? 138.37638 -28.80490 -15.86200 1.000 20.58239  ? 255 PHE A N   1 
ATOM   1800 C CA  . PHE A 1 256 ? 139.62865 -28.09167 -15.63540 1.000 22.79554  ? 255 PHE A CA  1 
ATOM   1801 C C   . PHE A 1 256 ? 140.18248 -27.55667 -16.95398 1.000 23.46834  ? 255 PHE A C   1 
ATOM   1802 O O   . PHE A 1 256 ? 140.48973 -28.32409 -17.87227 1.000 23.95649  ? 255 PHE A O   1 
ATOM   1803 C CB  . PHE A 1 256 ? 140.63321 -28.98314 -14.90020 1.000 22.26422  ? 255 PHE A CB  1 
ATOM   1804 C CG  . PHE A 1 256 ? 140.37904 -29.02970 -13.42391 1.000 21.22600  ? 255 PHE A CG  1 
ATOM   1805 C CD1 . PHE A 1 256 ? 139.48698 -29.94653 -12.89184 1.000 24.37197  ? 255 PHE A CD1 1 
ATOM   1806 C CD2 . PHE A 1 256 ? 140.97083 -28.11165 -12.58035 1.000 22.74883  ? 255 PHE A CD2 1 
ATOM   1807 C CE1 . PHE A 1 256 ? 139.21549 -29.96171 -11.52885 1.000 21.48218  ? 255 PHE A CE1 1 
ATOM   1808 C CE2 . PHE A 1 256 ? 140.69345 -28.11639 -11.22361 1.000 23.02761  ? 255 PHE A CE2 1 
ATOM   1809 C CZ  . PHE A 1 256 ? 139.81434 -29.04495 -10.70244 1.000 23.49272  ? 255 PHE A CZ  1 
ATOM   1810 N N   . ARG A 1 257 ? 140.28876 -26.23215 -17.04349 1.000 24.23275  ? 256 ARG A N   1 
ATOM   1811 C CA  . ARG A 1 257 ? 140.69759 -25.54798 -18.26571 1.000 28.48399  ? 256 ARG A CA  1 
ATOM   1812 C C   . ARG A 1 257 ? 142.20248 -25.31913 -18.33598 1.000 27.54034  ? 256 ARG A C   1 
ATOM   1813 O O   . ARG A 1 257 ? 142.70045 -24.84364 -19.35952 1.000 28.34396  ? 256 ARG A O   1 
ATOM   1814 C CB  . ARG A 1 257 ? 139.95253 -24.20398 -18.37473 1.000 24.31540  ? 256 ARG A CB  1 
ATOM   1815 C CG  . ARG A 1 257 ? 140.29121 -23.19835 -17.24401 1.000 27.16160  ? 256 ARG A CG  1 
ATOM   1816 C CD  . ARG A 1 257 ? 139.29540 -22.02680 -17.22549 1.000 29.33226  ? 256 ARG A CD  1 
ATOM   1817 N NE  . ARG A 1 257 ? 137.98586 -22.43850 -16.72356 1.000 30.10451  ? 256 ARG A NE  1 
ATOM   1818 C CZ  . ARG A 1 257 ? 136.89217 -21.68561 -16.75165 1.000 33.67740  ? 256 ARG A CZ  1 
ATOM   1819 N NH1 . ARG A 1 257 ? 136.91427 -20.45009 -17.22297 1.000 30.52784  ? 256 ARG A NH1 1 
ATOM   1820 N NH2 . ARG A 1 257 ? 135.74663 -22.18812 -16.29928 1.000 29.62142  ? 256 ARG A NH2 1 
ATOM   1821 N N   . GLN A 1 258 ? 142.92820 -25.65339 -17.27473 1.000 24.89013  ? 257 GLN A N   1 
ATOM   1822 C CA  . GLN A 1 258 ? 144.37632 -25.57689 -17.22314 1.000 25.14211  ? 257 GLN A CA  1 
ATOM   1823 C C   . GLN A 1 258 ? 144.89225 -26.90769 -16.70322 1.000 22.25518  ? 257 GLN A C   1 
ATOM   1824 O O   . GLN A 1 258 ? 144.15626 -27.66250 -16.06021 1.000 21.18807  ? 257 GLN A O   1 
ATOM   1825 C CB  . GLN A 1 258 ? 144.83735 -24.44001 -16.29220 1.000 28.84854  ? 257 GLN A CB  1 
ATOM   1826 C CG  . GLN A 1 258 ? 144.65402 -23.06640 -16.88558 1.000 40.08397  ? 257 GLN A CG  1 
ATOM   1827 C CD  . GLN A 1 258 ? 145.78153 -22.70717 -17.82240 1.000 38.16359  ? 257 GLN A CD  1 
ATOM   1828 O OE1 . GLN A 1 258 ? 146.95689 -22.84692 -17.47844 1.000 41.34587  ? 257 GLN A OE1 1 
ATOM   1829 N NE2 . GLN A 1 258 ? 145.43180 -22.25774 -19.02143 1.000 54.25815  ? 257 GLN A NE2 1 
ATOM   1830 N N   . ARG A 1 259 ? 146.16539 -27.18673 -16.95386 1.000 20.03132  ? 258 ARG A N   1 
ATOM   1831 C CA  . ARG A 1 259 ? 146.77511 -28.34746 -16.31712 1.000 19.95052  ? 258 ARG A CA  1 
ATOM   1832 C C   . ARG A 1 259 ? 146.82642 -28.13008 -14.80960 1.000 24.51190  ? 258 ARG A C   1 
ATOM   1833 O O   . ARG A 1 259 ? 147.45106 -27.17891 -14.33201 1.000 21.99223  ? 258 ARG A O   1 
ATOM   1834 C CB  . ARG A 1 259 ? 148.18198 -28.59359 -16.85987 1.000 23.19849  ? 258 ARG A CB  1 
ATOM   1835 C CG  . ARG A 1 259 ? 148.70177 -30.02340 -16.60987 1.000 25.44752  ? 258 ARG A CG  1 
ATOM   1836 C CD  . ARG A 1 259 ? 149.25386 -30.23353 -15.22308 1.000 30.51350  ? 258 ARG A CD  1 
ATOM   1837 N NE  . ARG A 1 259 ? 149.45274 -31.65096 -14.91828 1.000 27.38011  ? 258 ARG A NE  1 
ATOM   1838 C CZ  . ARG A 1 259 ? 149.96874 -32.08977 -13.77683 1.000 38.56684  ? 258 ARG A CZ  1 
ATOM   1839 N NH1 . ARG A 1 259 ? 150.34770 -31.24706 -12.81456 1.000 32.66928  ? 258 ARG A NH1 1 
ATOM   1840 N NH2 . ARG A 1 259 ? 150.10203 -33.40075 -13.58858 1.000 33.35748  ? 258 ARG A NH2 1 
ATOM   1841 N N   . VAL A 1 260 ? 146.18475 -29.02722 -14.06339 1.000 20.14973  ? 259 VAL A N   1 
ATOM   1842 C CA  . VAL A 1 260 ? 146.14729 -28.98299 -12.60610 1.000 19.46242  ? 259 VAL A CA  1 
ATOM   1843 C C   . VAL A 1 260 ? 146.43646 -30.38642 -12.09429 1.000 23.63808  ? 259 VAL A C   1 
ATOM   1844 O O   . VAL A 1 260 ? 145.94844 -31.37511 -12.65959 1.000 23.44822  ? 259 VAL A O   1 
ATOM   1845 C CB  . VAL A 1 260 ? 144.78247 -28.46509 -12.09173 1.000 21.76364  ? 259 VAL A CB  1 
ATOM   1846 C CG1 . VAL A 1 260 ? 144.68573 -28.58287 -10.56406 1.000 20.75624  ? 259 VAL A CG1 1 
ATOM   1847 C CG2 . VAL A 1 260 ? 144.54786 -27.00954 -12.54373 1.000 21.74283  ? 259 VAL A CG2 1 
ATOM   1848 N N   . SER A 1 261 ? 147.25177 -30.48046 -11.04366 1.000 20.35541  ? 260 SER A N   1 
ATOM   1849 C CA  . SER A 1 261 ? 147.68169 -31.78158 -10.54058 1.000 23.51315  ? 260 SER A CA  1 
ATOM   1850 C C   . SER A 1 261 ? 146.47554 -32.56861 -10.06451 1.000 26.38954  ? 260 SER A C   1 
ATOM   1851 O O   . SER A 1 261 ? 145.45208 -31.99265 -9.70091  1.000 21.42064  ? 260 SER A O   1 
ATOM   1852 C CB  . SER A 1 261 ? 148.68793 -31.64031 -9.39453  1.000 27.86393  ? 260 SER A CB  1 
ATOM   1853 O OG  . SER A 1 261 ? 148.04562 -31.11348 -8.24783  1.000 23.27715  ? 260 SER A OG  1 
HETATM 1854 N N   . SEP A 1 262 ? 146.59508 -33.88873 -10.07627 1.000 23.37000  ? 261 SEP A N   1 
HETATM 1855 C CA  . SEP A 1 262 ? 145.49825 -34.73480 -9.63792  1.000 23.36877  ? 261 SEP A CA  1 
HETATM 1856 C CB  . SEP A 1 262 ? 145.86671 -36.20346 -9.85450  1.000 29.51510  ? 261 SEP A CB  1 
HETATM 1857 O OG  . SEP A 1 262 ? 146.02797 -36.44518 -11.24471 1.000 33.01108  ? 261 SEP A OG  1 
HETATM 1858 C C   . SEP A 1 262 ? 145.12889 -34.47198 -8.17073  1.000 26.20757  ? 261 SEP A C   1 
HETATM 1859 O O   . SEP A 1 262 ? 143.95181 -34.49257 -7.81025  1.000 23.18944  ? 261 SEP A O   1 
HETATM 1860 P P   . SEP A 1 262 ? 147.55578 -36.78748 -11.70056 0.609 43.19447  ? 261 SEP A P   1 
HETATM 1861 O O1P . SEP A 1 262 ? 148.08993 -38.11516 -10.96860 0.609 39.36616  ? 261 SEP A O1P 1 
HETATM 1862 O O2P . SEP A 1 262 ? 147.57115 -37.07228 -13.30725 0.609 24.95512  ? 261 SEP A O2P 1 
HETATM 1863 O O3P . SEP A 1 262 ? 148.52705 -35.56491 -11.24189 0.609 30.16550  ? 261 SEP A O3P 1 
ATOM   1864 N N   . GLU A 1 263 ? 146.12817 -34.21719 -7.33037  1.000 22.50077  ? 262 GLU A N   1 
ATOM   1865 C CA  . GLU A 1 263 ? 145.86129 -33.93173 -5.91962  1.000 24.47157  ? 262 GLU A CA  1 
ATOM   1866 C C   . GLU A 1 263 ? 145.08300 -32.62405 -5.74089  1.000 22.69987  ? 262 GLU A C   1 
ATOM   1867 O O   . GLU A 1 263 ? 144.14417 -32.53275 -4.94007  1.000 21.13520  ? 262 GLU A O   1 
ATOM   1868 C CB  . GLU A 1 263 ? 147.18053 -33.88562 -5.13593  1.000 26.67762  ? 262 GLU A CB  1 
ATOM   1869 C CG  . GLU A 1 263 ? 147.95989 -35.21286 -5.13955  1.000 32.27068  ? 262 GLU A CG  1 
ATOM   1870 C CD  . GLU A 1 263 ? 148.78119 -35.47768 -6.42550  1.000 41.08434  ? 262 GLU A CD  1 
ATOM   1871 O OE2 . GLU A 1 263 ? 148.74331 -34.69698 -7.41891  1.000 32.79847  ? 262 GLU A OE2 1 
ATOM   1872 N N   . CYS A 1 264 ? 145.47790 -31.59264 -6.48478  1.000 21.37971  ? 263 CYS A N   1 
ATOM   1873 C CA  . CYS A 1 264 ? 144.74006 -30.33127 -6.41322  1.000 20.80445  ? 263 CYS A CA  1 
ATOM   1874 C C   . CYS A 1 264 ? 143.31937 -30.47233 -6.95672  1.000 22.22459  ? 263 CYS A C   1 
ATOM   1875 O O   . CYS A 1 264 ? 142.37075 -29.92320 -6.37866  1.000 19.81296  ? 263 CYS A O   1 
ATOM   1876 C CB  . CYS A 1 264 ? 145.49694 -29.24040 -7.16815  1.000 21.09664  ? 263 CYS A CB  1 
ATOM   1877 S SG  . CYS A 1 264 ? 144.75992 -27.58249 -7.03469  1.000 24.34147  ? 263 CYS A SG  1 
ATOM   1878 N N   . GLN A 1 265 ? 143.14872 -31.16336 -8.09226  1.000 21.48505  ? 264 GLN A N   1 
ATOM   1879 C CA  . GLN A 1 265 ? 141.80082 -31.40044 -8.60311  1.000 20.49152  ? 264 GLN A CA  1 
ATOM   1880 C C   . GLN A 1 265 ? 140.92763 -32.09418 -7.56740  1.000 21.20943  ? 264 GLN A C   1 
ATOM   1881 O O   . GLN A 1 265 ? 139.73474 -31.78869 -7.44338  1.000 20.74114  ? 264 GLN A O   1 
ATOM   1882 C CB  . GLN A 1 265 ? 141.84263 -32.26858 -9.86541  1.000 19.08389  ? 264 GLN A CB  1 
ATOM   1883 C CG  . GLN A 1 265 ? 142.42137 -31.60366 -11.10964 1.000 21.31033  ? 264 GLN A CG  1 
ATOM   1884 C CD  . GLN A 1 265 ? 142.04720 -32.37583 -12.36676 1.000 25.80808  ? 264 GLN A CD  1 
ATOM   1885 O OE1 . GLN A 1 265 ? 141.20603 -33.27310 -12.32047 1.000 27.82671  ? 264 GLN A OE1 1 
ATOM   1886 N NE2 . GLN A 1 265 ? 142.65232 -32.02514 -13.49079 1.000 22.00521  ? 264 GLN A NE2 1 
ATOM   1887 N N   . HIS A 1 266 ? 141.48698 -33.08170 -6.86596  1.000 19.87320  ? 265 HIS A N   1 
ATOM   1888 C CA  . HIS A 1 266 ? 140.70588 -33.81143 -5.87294  1.000 23.31244  ? 265 HIS A CA  1 
ATOM   1889 C C   . HIS A 1 266 ? 140.24594 -32.88690 -4.74850  1.000 24.00629  ? 265 HIS A C   1 
ATOM   1890 O O   . HIS A 1 266 ? 139.08096 -32.92957 -4.32719  1.000 21.13665  ? 265 HIS A O   1 
ATOM   1891 C CB  . HIS A 1 266 ? 141.53569 -34.97645 -5.32241  1.000 22.88628  ? 265 HIS A CB  1 
ATOM   1892 C CG  . HIS A 1 266 ? 140.88455 -35.69674 -4.18289  1.000 24.97220  ? 265 HIS A CG  1 
ATOM   1893 N ND1 . HIS A 1 266 ? 140.96182 -35.25362 -2.88172  1.000 28.00491  ? 265 HIS A ND1 1 
ATOM   1894 C CD2 . HIS A 1 266 ? 140.13386 -36.82643 -4.15395  1.000 31.13485  ? 265 HIS A CD2 1 
ATOM   1895 C CE1 . HIS A 1 266 ? 140.29222 -36.08112 -2.09653  1.000 33.66475  ? 265 HIS A CE1 1 
ATOM   1896 N NE2 . HIS A 1 266 ? 139.78091 -37.04449 -2.84320  1.000 26.96699  ? 265 HIS A NE2 1 
ATOM   1897 N N   . LEU A 1 267 ? 141.13759 -32.02929 -4.25970  1.000 20.45663  ? 266 LEU A N   1 
ATOM   1898 C CA  . LEU A 1 267 ? 140.73441 -31.10315 -3.20445  1.000 22.70530  ? 266 LEU A CA  1 
ATOM   1899 C C   . LEU A 1 267 ? 139.64433 -30.15152 -3.68689  1.000 20.34161  ? 266 LEU A C   1 
ATOM   1900 O O   . LEU A 1 267 ? 138.66094 -29.92199 -2.97538  1.000 19.37239  ? 266 LEU A O   1 
ATOM   1901 C CB  . LEU A 1 267 ? 141.94220 -30.32534 -2.68163  1.000 17.59635  ? 266 LEU A CB  1 
ATOM   1902 C CG  . LEU A 1 267 ? 141.64686 -29.27195 -1.59651  1.000 22.83880  ? 266 LEU A CG  1 
ATOM   1903 C CD1 . LEU A 1 267 ? 140.94601 -29.87469 -0.34571  1.000 18.68753  ? 266 LEU A CD1 1 
ATOM   1904 C CD2 . LEU A 1 267 ? 142.94660 -28.54187 -1.17805  1.000 21.21944  ? 266 LEU A CD2 1 
ATOM   1905 N N   . ILE A 1 268 ? 139.79666 -29.58512 -4.89218  1.000 18.76572  ? 267 ILE A N   1 
ATOM   1906 C CA  . ILE A 1 268 ? 138.77034 -28.69361 -5.41822  1.000 17.93846  ? 267 ILE A CA  1 
ATOM   1907 C C   . ILE A 1 268 ? 137.43944 -29.42404 -5.52573  1.000 20.56344  ? 267 ILE A C   1 
ATOM   1908 O O   . ILE A 1 268 ? 136.39513 -28.92148 -5.08859  1.000 20.78178  ? 267 ILE A O   1 
ATOM   1909 C CB  . ILE A 1 268 ? 139.19482 -28.12404 -6.78209  1.000 20.84578  ? 267 ILE A CB  1 
ATOM   1910 C CG1 . ILE A 1 268 ? 140.35971 -27.13728 -6.60967  1.000 18.92857  ? 267 ILE A CG1 1 
ATOM   1911 C CG2 . ILE A 1 268 ? 138.00378 -27.46389 -7.47756  1.000 20.41461  ? 267 ILE A CG2 1 
ATOM   1912 C CD1 . ILE A 1 268 ? 141.08231 -26.82033 -7.93260  1.000 18.00041  ? 267 ILE A CD1 1 
ATOM   1913 N N   . ARG A 1 269 ? 137.44790 -30.60953 -6.13720  1.000 20.60404  ? 268 ARG A N   1 
ATOM   1914 C CA  . ARG A 1 269 ? 136.17721 -31.31234 -6.31873  1.000 21.18476  ? 268 ARG A CA  1 
ATOM   1915 C C   . ARG A 1 269 ? 135.54930 -31.67725 -4.97905  1.000 24.65563  ? 268 ARG A C   1 
ATOM   1916 O O   . ARG A 1 269 ? 134.31919 -31.73794 -4.86783  1.000 22.64569  ? 268 ARG A O   1 
ATOM   1917 C CB  . ARG A 1 269 ? 136.37815 -32.56127 -7.16981  1.000 23.24696  ? 268 ARG A CB  1 
ATOM   1918 C CG  . ARG A 1 269 ? 136.60342 -32.24044 -8.65538  1.000 24.93731  ? 268 ARG A CG  1 
ATOM   1919 C CD  . ARG A 1 269 ? 136.35102 -33.45711 -9.51781  1.000 31.10739  ? 268 ARG A CD  1 
ATOM   1920 N NE  . ARG A 1 269 ? 136.43685 -33.12954 -10.93905 1.000 36.39335  ? 268 ARG A NE  1 
ATOM   1921 C CZ  . ARG A 1 269 ? 137.55116 -33.24143 -11.64399 1.000 34.67002  ? 268 ARG A CZ  1 
ATOM   1922 N NH1 . ARG A 1 269 ? 138.66621 -33.70616 -11.09423 1.000 28.74421  ? 268 ARG A NH1 1 
ATOM   1923 N NH2 . ARG A 1 269 ? 137.55263 -32.86440 -12.92175 1.000 28.12059  ? 268 ARG A NH2 1 
ATOM   1924 N N   . TRP A 1 270 ? 136.37213 -31.92015 -3.95662  1.000 21.56198  ? 269 TRP A N   1 
ATOM   1925 C CA  . TRP A 1 270 ? 135.84668 -32.22563 -2.62301  1.000 23.35654  ? 269 TRP A CA  1 
ATOM   1926 C C   . TRP A 1 270 ? 135.17357 -31.00212 -2.00782  1.000 20.56649  ? 269 TRP A C   1 
ATOM   1927 O O   . TRP A 1 270 ? 134.06654 -31.09608 -1.45831  1.000 20.75499  ? 269 TRP A O   1 
ATOM   1928 C CB  . TRP A 1 270 ? 136.98276 -32.73215 -1.73312  1.000 21.96843  ? 269 TRP A CB  1 
ATOM   1929 C CG  . TRP A 1 270 ? 136.57085 -33.38404 -0.43704  1.000 22.44826  ? 269 TRP A CG  1 
ATOM   1930 C CD1 . TRP A 1 270 ? 135.30891 -33.74110 -0.04054  1.000 24.85228  ? 269 TRP A CD1 1 
ATOM   1931 C CD2 . TRP A 1 270 ? 137.45169 -33.76417 0.62711   1.000 24.03089  ? 269 TRP A CD2 1 
ATOM   1932 N NE1 . TRP A 1 270 ? 135.35733 -34.32533 1.22330   1.000 24.30565  ? 269 TRP A NE1 1 
ATOM   1933 C CE2 . TRP A 1 270 ? 136.66099 -34.34685 1.64612   1.000 23.49438  ? 269 TRP A CE2 1 
ATOM   1934 C CE3 . TRP A 1 270 ? 138.83671 -33.67229 0.81311   1.000 23.48466  ? 269 TRP A CE3 1 
ATOM   1935 C CZ2 . TRP A 1 270 ? 137.21060 -34.83029 2.83645   1.000 24.44410  ? 269 TRP A CZ2 1 
ATOM   1936 C CZ3 . TRP A 1 270 ? 139.38474 -34.14792 2.00494   1.000 25.43732  ? 269 TRP A CZ3 1 
ATOM   1937 C CH2 . TRP A 1 270 ? 138.56665 -34.72093 3.00066   1.000 25.93904  ? 269 TRP A CH2 1 
ATOM   1938 N N   . CYS A 1 271 ? 135.83085 -29.83923 -2.09343  1.000 19.32697  ? 270 CYS A N   1 
ATOM   1939 C CA  . CYS A 1 271 ? 135.21413 -28.59482 -1.63570  1.000 22.20150  ? 270 CYS A CA  1 
ATOM   1940 C C   . CYS A 1 271 ? 133.93029 -28.27789 -2.38687  1.000 20.94959  ? 270 CYS A C   1 
ATOM   1941 O O   . CYS A 1 271 ? 133.02606 -27.64550 -1.82265  1.000 21.45432  ? 270 CYS A O   1 
ATOM   1942 C CB  . CYS A 1 271 ? 136.18027 -27.41654 -1.80474  1.000 17.80523  ? 270 CYS A CB  1 
ATOM   1943 S SG  . CYS A 1 271 ? 137.65127 -27.49238 -0.72564  1.000 21.58323  ? 270 CYS A SG  1 
ATOM   1944 N N   . LEU A 1 272 ? 133.84582 -28.66491 -3.66418  1.000 19.61555  ? 271 LEU A N   1 
ATOM   1945 C CA  . LEU A 1 272 ? 132.67573 -28.39194 -4.48516  1.000 21.26994  ? 271 LEU A CA  1 
ATOM   1946 C C   . LEU A 1 272 ? 131.71524 -29.57662 -4.51917  1.000 21.66869  ? 271 LEU A C   1 
ATOM   1947 O O   . LEU A 1 272 ? 130.96280 -29.73680 -5.48294  1.000 23.21043  ? 271 LEU A O   1 
ATOM   1948 C CB  . LEU A 1 272 ? 133.09319 -27.99500 -5.90210  1.000 20.56305  ? 271 LEU A CB  1 
ATOM   1949 C CG  . LEU A 1 272 ? 133.97133 -26.73315 -5.94605  1.000 21.46869  ? 271 LEU A CG  1 
ATOM   1950 C CD1 . LEU A 1 272 ? 134.36483 -26.34937 -7.39195  1.000 21.05617  ? 271 LEU A CD1 1 
ATOM   1951 C CD2 . LEU A 1 272 ? 133.29686 -25.56976 -5.22607  1.000 18.38530  ? 271 LEU A CD2 1 
ATOM   1952 N N   . ALA A 1 273 ? 131.72864 -30.41322 -3.48426  1.000 24.01661  ? 272 ALA A N   1 
ATOM   1953 C CA  . ALA A 1 273 ? 130.73709 -31.47376 -3.39929  1.000 25.07048  ? 272 ALA A CA  1 
ATOM   1954 C C   . ALA A 1 273 ? 129.33919 -30.86780 -3.39147  1.000 26.77689  ? 272 ALA A C   1 
ATOM   1955 O O   . ALA A 1 273 ? 129.07945 -29.89304 -2.68594  1.000 23.92722  ? 272 ALA A O   1 
ATOM   1956 C CB  . ALA A 1 273 ? 130.95722 -32.31164 -2.13905  1.000 23.80601  ? 272 ALA A CB  1 
ATOM   1957 N N   . LEU A 1 274 ? 128.42528 -31.45926 -4.17256  1.000 26.01189  ? 273 LEU A N   1 
ATOM   1958 C CA  . LEU A 1 274 ? 127.06159 -30.93155 -4.22251  1.000 23.86042  ? 273 LEU A CA  1 
ATOM   1959 C C   . LEU A 1 274 ? 126.36277 -31.02111 -2.86439  1.000 27.26214  ? 273 LEU A C   1 
ATOM   1960 O O   . LEU A 1 274 ? 125.66367 -30.08472 -2.46216  1.000 25.80277  ? 273 LEU A O   1 
ATOM   1961 C CB  . LEU A 1 274 ? 126.24366 -31.65398 -5.29374  1.000 24.57305  ? 273 LEU A CB  1 
ATOM   1962 C CG  . LEU A 1 274 ? 126.55031 -31.25159 -6.74707  1.000 27.02309  ? 273 LEU A CG  1 
ATOM   1963 C CD1 . LEU A 1 274 ? 125.62774 -31.96634 -7.72974  1.000 30.92248  ? 273 LEU A CD1 1 
ATOM   1964 C CD2 . LEU A 1 274 ? 126.47242 -29.73901 -6.92773  1.000 27.77809  ? 273 LEU A CD2 1 
ATOM   1965 N N   . ARG A 1 275 ? 126.50665 -32.14168 -2.15498  1.000 26.05022  ? 274 ARG A N   1 
ATOM   1966 C CA  . ARG A 1 275 ? 125.85320 -32.22588 -0.84607  1.000 27.23346  ? 274 ARG A CA  1 
ATOM   1967 C C   . ARG A 1 275 ? 126.73593 -31.54953 0.19522   1.000 28.09622  ? 274 ARG A C   1 
ATOM   1968 O O   . ARG A 1 275 ? 127.92487 -31.85921 0.27082   1.000 26.82424  ? 274 ARG A O   1 
ATOM   1969 C CB  . ARG A 1 275 ? 125.58533 -33.67711 -0.45043  1.000 32.55344  ? 274 ARG A CB  1 
ATOM   1970 C CG  . ARG A 1 275 ? 125.16221 -33.88008 1.03381   1.000 40.19223  ? 274 ARG A CG  1 
ATOM   1971 C CD  . ARG A 1 275 ? 123.80565 -33.22312 1.37117   1.000 56.28301  ? 274 ARG A CD  1 
ATOM   1972 N NE  . ARG A 1 275 ? 123.28716 -33.55811 2.70099   1.000 63.63945  ? 274 ARG A NE  1 
ATOM   1973 C CZ  . ARG A 1 275 ? 123.41625 -32.80063 3.78493   1.000 44.97708  ? 274 ARG A CZ  1 
ATOM   1974 N NH1 . ARG A 1 275 ? 124.09085 -31.66446 3.75724   1.000 36.74213  ? 274 ARG A NH1 1 
ATOM   1975 N NH2 . ARG A 1 275 ? 122.85614 -33.19841 4.93229   1.000 50.80765  ? 274 ARG A NH2 1 
ATOM   1976 N N   . PRO A 1 276 ? 126.20428 -30.60131 0.98038   1.000 28.40314  ? 275 PRO A N   1 
ATOM   1977 C CA  . PRO A 1 276 ? 127.06738 -29.87894 1.93779   1.000 26.76343  ? 275 PRO A CA  1 
ATOM   1978 C C   . PRO A 1 276 ? 127.79312 -30.78537 2.91155   1.000 28.51895  ? 275 PRO A C   1 
ATOM   1979 O O   . PRO A 1 276 ? 128.95887 -30.52764 3.23508   1.000 25.56263  ? 275 PRO A O   1 
ATOM   1980 C CB  . PRO A 1 276 ? 126.07833 -28.94841 2.65814   1.000 30.52889  ? 275 PRO A CB  1 
ATOM   1981 C CG  . PRO A 1 276 ? 125.01818 -28.68487 1.62705   1.000 31.20754  ? 275 PRO A CG  1 
ATOM   1982 C CD  . PRO A 1 276 ? 124.87878 -29.96835 0.84097   1.000 30.68156  ? 275 PRO A CD  1 
ATOM   1983 N N   . SER A 1 277 ? 127.13985 -31.84503 3.40063   1.000 26.76988  ? 276 SER A N   1 
ATOM   1984 C CA  . SER A 1 277 ? 127.80543 -32.70587 4.37816   1.000 29.82250  ? 276 SER A CA  1 
ATOM   1985 C C   . SER A 1 277 ? 128.93315 -33.53649 3.76995   1.000 29.16747  ? 276 SER A C   1 
ATOM   1986 O O   . SER A 1 277 ? 129.71463 -34.12807 4.52068   1.000 35.05595  ? 276 SER A O   1 
ATOM   1987 C CB  . SER A 1 277 ? 126.78203 -33.63022 5.04966   1.000 31.08366  ? 276 SER A CB  1 
ATOM   1988 O OG  . SER A 1 277 ? 126.08873 -34.40763 4.07920   1.000 34.01217  ? 276 SER A OG  1 
ATOM   1989 N N   . ASP A 1 278 ? 129.03880 -33.59271 2.44085   1.000 29.56918  ? 277 ASP A N   1 
ATOM   1990 C CA  . ASP A 1 278 ? 130.13937 -34.26931 1.76803   1.000 26.56105  ? 277 ASP A CA  1 
ATOM   1991 C C   . ASP A 1 278 ? 131.38004 -33.39348 1.62286   1.000 28.67154  ? 277 ASP A C   1 
ATOM   1992 O O   . ASP A 1 278 ? 132.41170 -33.89089 1.16502   1.000 29.11719  ? 277 ASP A O   1 
ATOM   1993 C CB  . ASP A 1 278 ? 129.72323 -34.72598 0.36778   1.000 25.35476  ? 277 ASP A CB  1 
ATOM   1994 C CG  . ASP A 1 278 ? 128.80813 -35.94117 0.37493   1.000 32.41949  ? 277 ASP A CG  1 
ATOM   1995 O OD1 . ASP A 1 278 ? 128.67893 -36.61047 1.41689   1.000 32.84726  ? 277 ASP A OD1 1 
ATOM   1996 O OD2 . ASP A 1 278 ? 128.22820 -36.22474 -0.69301  1.000 33.91329  ? 277 ASP A OD2 1 
ATOM   1997 N N   . ARG A 1 279 ? 131.30005 -32.10625 1.96471   1.000 24.28851  ? 278 ARG A N   1 
ATOM   1998 C CA  . ARG A 1 279 ? 132.44571 -31.22051 1.82434   1.000 23.09728  ? 278 ARG A CA  1 
ATOM   1999 C C   . ARG A 1 279 ? 133.41118 -31.40593 2.99424   1.000 22.82289  ? 278 ARG A C   1 
ATOM   2000 O O   . ARG A 1 279 ? 133.00604 -31.83738 4.07765   1.000 23.54581  ? 278 ARG A O   1 
ATOM   2001 C CB  . ARG A 1 279 ? 131.97822 -29.76678 1.74956   1.000 22.09422  ? 278 ARG A CB  1 
ATOM   2002 C CG  . ARG A 1 279 ? 131.14305 -29.50990 0.48142   1.000 20.77147  ? 278 ARG A CG  1 
ATOM   2003 C CD  . ARG A 1 279 ? 130.56318 -28.09126 0.38549   1.000 23.13437  ? 278 ARG A CD  1 
ATOM   2004 N NE  . ARG A 1 279 ? 129.45672 -28.09815 -0.57256  1.000 21.47609  ? 278 ARG A NE  1 
ATOM   2005 C CZ  . ARG A 1 279 ? 128.34811 -27.37523 -0.46508  1.000 25.22432  ? 278 ARG A CZ  1 
ATOM   2006 N NH1 . ARG A 1 279 ? 128.19739 -26.46620 0.49551   1.000 22.14592  ? 278 ARG A NH1 1 
ATOM   2007 N NH2 . ARG A 1 279 ? 127.35156 -27.59386 -1.32084  1.000 23.69910  ? 278 ARG A NH2 1 
ATOM   2008 N N   . PRO A 1 280 ? 134.69579 -31.11622 2.79659   1.000 21.87126  ? 279 PRO A N   1 
ATOM   2009 C CA  . PRO A 1 280 ? 135.65164 -31.25392 3.90074   1.000 21.59568  ? 279 PRO A CA  1 
ATOM   2010 C C   . PRO A 1 280 ? 135.46209 -30.17146 4.95319   1.000 25.11756  ? 279 PRO A C   1 
ATOM   2011 O O   . PRO A 1 280 ? 134.96216 -29.08016 4.67405   1.000 23.52582  ? 279 PRO A O   1 
ATOM   2012 C CB  . PRO A 1 280 ? 137.01352 -31.10553 3.20971   1.000 22.35205  ? 279 PRO A CB  1 
ATOM   2013 C CG  . PRO A 1 280 ? 136.73030 -30.24053 2.02669   1.000 22.51878  ? 279 PRO A CG  1 
ATOM   2014 C CD  . PRO A 1 280 ? 135.35549 -30.67926 1.54611   1.000 20.75227  ? 279 PRO A CD  1 
ATOM   2015 N N   . THR A 1 281 ? 135.86155 -30.49334 6.18603   1.000 24.13348  ? 280 THR A N   1 
ATOM   2016 C CA  . THR A 1 281 ? 136.04574 -29.46476 7.20451   1.000 24.70548  ? 280 THR A CA  1 
ATOM   2017 C C   . THR A 1 281 ? 137.32141 -28.67520 6.90933   1.000 25.87266  ? 280 THR A C   1 
ATOM   2018 O O   . THR A 1 281 ? 138.15247 -29.08950 6.10036   1.000 22.27091  ? 280 THR A O   1 
ATOM   2019 C CB  . THR A 1 281 ? 136.16871 -30.09644 8.59204   1.000 25.07243  ? 280 THR A CB  1 
ATOM   2020 O OG1 . THR A 1 281 ? 137.34867 -30.92051 8.61020   1.000 25.03351  ? 280 THR A OG1 1 
ATOM   2021 C CG2 . THR A 1 281 ? 134.93212 -30.95564 8.91143   1.000 27.66462  ? 280 THR A CG2 1 
ATOM   2022 N N   . PHE A 1 282 ? 137.50286 -27.54117 7.60147   1.000 24.23335  ? 281 PHE A N   1 
ATOM   2023 C CA  . PHE A 1 282 ? 138.76637 -26.81505 7.45508   1.000 25.52711  ? 281 PHE A CA  1 
ATOM   2024 C C   . PHE A 1 282 ? 139.95332 -27.70173 7.80761   1.000 24.87124  ? 281 PHE A C   1 
ATOM   2025 O O   . PHE A 1 282 ? 141.00094 -27.62270 7.16092   1.000 22.11102  ? 281 PHE A O   1 
ATOM   2026 C CB  . PHE A 1 282 ? 138.80037 -25.55760 8.32535   1.000 23.61486  ? 281 PHE A CB  1 
ATOM   2027 C CG  . PHE A 1 282 ? 137.73024 -24.54924 8.00429   1.000 30.74783  ? 281 PHE A CG  1 
ATOM   2028 C CD1 . PHE A 1 282 ? 137.34125 -24.30245 6.70890   1.000 35.78851  ? 281 PHE A CD1 1 
ATOM   2029 C CD2 . PHE A 1 282 ? 137.11669 -23.83511 9.03129   1.000 41.34200  ? 281 PHE A CD2 1 
ATOM   2030 C CE1 . PHE A 1 282 ? 136.34702 -23.35152 6.42262   1.000 29.05543  ? 281 PHE A CE1 1 
ATOM   2031 C CE2 . PHE A 1 282 ? 136.13043 -22.89925 8.75883   1.000 40.50235  ? 281 PHE A CE2 1 
ATOM   2032 C CZ  . PHE A 1 282 ? 135.74475 -22.66310 7.44002   1.000 36.84469  ? 281 PHE A CZ  1 
ATOM   2033 N N   . GLU A 1 283 ? 139.81878 -28.53143 8.85003   1.000 21.70308  ? 282 GLU A N   1 
ATOM   2034 C CA  . GLU A 1 283 ? 140.90292 -29.43724 9.22450   1.000 25.07501  ? 282 GLU A CA  1 
ATOM   2035 C C   . GLU A 1 283 ? 141.22782 -30.40811 8.09497   1.000 24.30684  ? 282 GLU A C   1 
ATOM   2036 O O   . GLU A 1 283 ? 142.40246 -30.65467 7.79763   1.000 23.00168  ? 282 GLU A O   1 
ATOM   2037 C CB  . GLU A 1 283 ? 140.53659 -30.20889 10.50301  1.000 24.36733  ? 282 GLU A CB  1 
ATOM   2038 C CG  . GLU A 1 283 ? 141.54689 -31.27297 10.88904  1.000 21.98567  ? 282 GLU A CG  1 
ATOM   2039 C CD  . GLU A 1 283 ? 141.16487 -31.99873 12.17574  1.000 41.26850  ? 282 GLU A CD  1 
ATOM   2040 O OE1 . GLU A 1 283 ? 139.96140 -32.06107 12.49724  1.000 36.20229  ? 282 GLU A OE1 1 
ATOM   2041 O OE2 . GLU A 1 283 ? 142.07069 -32.50273 12.86503  1.000 35.95882  ? 282 GLU A OE2 1 
ATOM   2042 N N   . GLU A 1 284 ? 140.20120 -30.96770 7.44971   1.000 22.40318  ? 283 GLU A N   1 
ATOM   2043 C CA  . GLU A 1 284 ? 140.45193 -31.91524 6.37094   1.000 22.83263  ? 283 GLU A CA  1 
ATOM   2044 C C   . GLU A 1 284 ? 141.09717 -31.22787 5.17195   1.000 22.28538  ? 283 GLU A C   1 
ATOM   2045 O O   . GLU A 1 284 ? 141.93626 -31.82719 4.49162   1.000 22.53632  ? 283 GLU A O   1 
ATOM   2046 C CB  . GLU A 1 284 ? 139.15610 -32.61427 5.96519   1.000 26.52084  ? 283 GLU A CB  1 
ATOM   2047 C CG  . GLU A 1 284 ? 138.66841 -33.66296 6.99697   1.000 25.74390  ? 283 GLU A CG  1 
ATOM   2048 C CD  . GLU A 1 284 ? 137.29731 -34.20011 6.65027   1.000 32.39025  ? 283 GLU A CD  1 
ATOM   2049 O OE1 . GLU A 1 284 ? 136.38710 -33.37932 6.40719   1.000 26.57999  ? 283 GLU A OE1 1 
ATOM   2050 O OE2 . GLU A 1 284 ? 137.14257 -35.43547 6.60443   1.000 31.97970  ? 283 GLU A OE2 1 
ATOM   2051 N N   . ILE A 1 285 ? 140.72355 -29.97517 4.89505   1.000 20.84711  ? 284 ILE A N   1 
ATOM   2052 C CA  . ILE A 1 285 ? 141.38782 -29.23371 3.81612   1.000 21.07931  ? 284 ILE A CA  1 
ATOM   2053 C C   . ILE A 1 285 ? 142.87092 -29.07706 4.12426   1.000 22.38787  ? 284 ILE A C   1 
ATOM   2054 O O   . ILE A 1 285 ? 143.74086 -29.37633 3.29622   1.000 22.03328  ? 284 ILE A O   1 
ATOM   2055 C CB  . ILE A 1 285 ? 140.72904 -27.85724 3.60993   1.000 20.71126  ? 284 ILE A CB  1 
ATOM   2056 C CG1 . ILE A 1 285 ? 139.28578 -27.99932 3.11420   1.000 20.12471  ? 284 ILE A CG1 1 
ATOM   2057 C CG2 . ILE A 1 285 ? 141.58352 -26.99143 2.64349   1.000 20.82184  ? 284 ILE A CG2 1 
ATOM   2058 C CD1 . ILE A 1 285 ? 138.52138 -26.66345 3.14284   1.000 22.18102  ? 284 ILE A CD1 1 
ATOM   2059 N N   . GLN A 1 286 ? 143.18416 -28.57641 5.31578   1.000 18.24302  ? 285 GLN A N   1 
ATOM   2060 C CA  . GLN A 1 286 ? 144.58598 -28.31949 5.62484   1.000 18.84821  ? 285 GLN A CA  1 
ATOM   2061 C C   . GLN A 1 286 ? 145.39810 -29.59165 5.82953   1.000 23.29275  ? 285 GLN A C   1 
ATOM   2062 O O   . GLN A 1 286 ? 146.63015 -29.53806 5.73089   1.000 24.53474  ? 285 GLN A O   1 
ATOM   2063 C CB  . GLN A 1 286 ? 144.70143 -27.41483 6.84440   1.000 21.10573  ? 285 GLN A CB  1 
ATOM   2064 C CG  . GLN A 1 286 ? 144.23184 -25.99607 6.55172   1.000 20.14698  ? 285 GLN A CG  1 
ATOM   2065 C CD  . GLN A 1 286 ? 144.53712 -25.05301 7.68342   1.000 23.55825  ? 285 GLN A CD  1 
ATOM   2066 O OE1 . GLN A 1 286 ? 143.96154 -25.16725 8.75842   1.000 23.91825  ? 285 GLN A OE1 1 
ATOM   2067 N NE2 . GLN A 1 286 ? 145.46043 -24.12020 7.45092   1.000 23.00138  ? 285 GLN A NE2 1 
ATOM   2068 N N   . ASN A 1 287 ? 144.75544 -30.72415 6.10921   1.000 20.55040  ? 286 ASN A N   1 
ATOM   2069 C CA  . ASN A 1 287 ? 145.47006 -31.99541 6.14976   1.000 21.60749  ? 286 ASN A CA  1 
ATOM   2070 C C   . ASN A 1 287 ? 145.53704 -32.67997 4.79270   1.000 26.34505  ? 286 ASN A C   1 
ATOM   2071 O O   . ASN A 1 287 ? 146.14013 -33.75614 4.68977   1.000 24.62608  ? 286 ASN A O   1 
ATOM   2072 C CB  . ASN A 1 287 ? 144.82510 -32.95254 7.16366   1.000 24.75613  ? 286 ASN A CB  1 
ATOM   2073 C CG  . ASN A 1 287 ? 145.13651 -32.58025 8.60301   1.000 30.67216  ? 286 ASN A CG  1 
ATOM   2074 O OD1 . ASN A 1 287 ? 146.20357 -32.04624 8.90957   1.000 28.69817  ? 286 ASN A OD1 1 
ATOM   2075 N ND2 . ASN A 1 287 ? 144.20294 -32.86773 9.49352   1.000 32.30167  ? 286 ASN A ND2 1 
ATOM   2076 N N   . HIS A 1 288 ? 144.94049 -32.08932 3.75745   1.000 22.95753  ? 287 HIS A N   1 
ATOM   2077 C CA  . HIS A 1 288 ? 144.93442 -32.71861 2.44127   1.000 24.68764  ? 287 HIS A CA  1 
ATOM   2078 C C   . HIS A 1 288 ? 146.35691 -32.81452 1.88955   1.000 23.66219  ? 287 HIS A C   1 
ATOM   2079 O O   . HIS A 1 288 ? 147.16100 -31.90769 2.09983   1.000 23.58623  ? 287 HIS A O   1 
ATOM   2080 C CB  . HIS A 1 288 ? 144.05442 -31.91373 1.48020   1.000 21.74833  ? 287 HIS A CB  1 
ATOM   2081 C CG  . HIS A 1 288 ? 143.76501 -32.61581 0.18929   1.000 22.29751  ? 287 HIS A CG  1 
ATOM   2082 N ND1 . HIS A 1 288 ? 144.64232 -32.60922 -0.87455  1.000 22.57260  ? 287 HIS A ND1 1 
ATOM   2083 C CD2 . HIS A 1 288 ? 142.69093 -33.34078 -0.21030  1.000 22.00906  ? 287 HIS A CD2 1 
ATOM   2084 C CE1 . HIS A 1 288 ? 144.11980 -33.29597 -1.87685  1.000 22.18777  ? 287 HIS A CE1 1 
ATOM   2085 N NE2 . HIS A 1 288 ? 142.93820 -33.75505 -1.49840  1.000 22.81866  ? 287 HIS A NE2 1 
ATOM   2086 N N   . PRO A 1 289 ? 146.69784 -33.90723 1.18558   1.000 23.85685  ? 288 PRO A N   1 
ATOM   2087 C CA  . PRO A 1 289 ? 148.06093 -34.03440 0.63208   1.000 27.19060  ? 288 PRO A CA  1 
ATOM   2088 C C   . PRO A 1 289 ? 148.51506 -32.83923 -0.19474  1.000 26.91241  ? 288 PRO A C   1 
ATOM   2089 O O   . PRO A 1 289 ? 149.69488 -32.46048 -0.12163  1.000 26.87719  ? 288 PRO A O   1 
ATOM   2090 C CB  . PRO A 1 289 ? 147.96391 -35.30154 -0.23227  1.000 29.78578  ? 288 PRO A CB  1 
ATOM   2091 C CG  . PRO A 1 289 ? 146.86675 -36.09595 0.39020   1.000 37.26475  ? 288 PRO A CG  1 
ATOM   2092 C CD  . PRO A 1 289 ? 145.86920 -35.09701 0.90627   1.000 27.99278  ? 288 PRO A CD  1 
ATOM   2093 N N   . TRP A 1 290 ? 147.61419 -32.22542 -0.97000  1.000 22.98818  ? 289 TRP A N   1 
ATOM   2094 C CA  . TRP A 1 290 ? 148.02190 -31.08523 -1.78739  1.000 23.42746  ? 289 TRP A CA  1 
ATOM   2095 C C   . TRP A 1 290 ? 148.47283 -29.89695 -0.93959  1.000 23.25196  ? 289 TRP A C   1 
ATOM   2096 O O   . TRP A 1 290 ? 149.24648 -29.06343 -1.42163  1.000 25.30450  ? 289 TRP A O   1 
ATOM   2097 C CB  . TRP A 1 290 ? 146.88382 -30.65714 -2.72372  1.000 21.65487  ? 289 TRP A CB  1 
ATOM   2098 C CG  . TRP A 1 290 ? 147.32342 -29.56249 -3.67410  1.000 21.21139  ? 289 TRP A CG  1 
ATOM   2099 C CD1 . TRP A 1 290 ? 148.11883 -29.70510 -4.76681  1.000 22.64438  ? 289 TRP A CD1 1 
ATOM   2100 C CD2 . TRP A 1 290 ? 147.03974 -28.16509 -3.55510  1.000 19.39808  ? 289 TRP A CD2 1 
ATOM   2101 N NE1 . TRP A 1 290 ? 148.32145 -28.47703 -5.36678  1.000 22.98150  ? 289 TRP A NE1 1 
ATOM   2102 C CE2 . TRP A 1 290 ? 147.67726 -27.51678 -4.63122  1.000 23.03546  ? 289 TRP A CE2 1 
ATOM   2103 C CE3 . TRP A 1 290 ? 146.29981 -27.39791 -2.64089  1.000 20.10228  ? 289 TRP A CE3 1 
ATOM   2104 C CZ2 . TRP A 1 290 ? 147.59948 -26.14102 -4.82564  1.000 23.36536  ? 289 TRP A CZ2 1 
ATOM   2105 C CZ3 . TRP A 1 290 ? 146.22681 -26.02254 -2.83072  1.000 20.00989  ? 289 TRP A CZ3 1 
ATOM   2106 C CH2 . TRP A 1 290 ? 146.87224 -25.41052 -3.92032  1.000 19.65366  ? 289 TRP A CH2 1 
ATOM   2107 N N   . MET A 1 291 ? 148.02946 -29.80466 0.31585   1.000 22.10702  ? 290 MET A N   1 
ATOM   2108 C CA  . MET A 1 291 ? 148.30274 -28.62941 1.13641   1.000 23.24930  ? 290 MET A CA  1 
ATOM   2109 C C   . MET A 1 291 ? 149.60546 -28.72748 1.90890   1.000 26.64392  ? 290 MET A C   1 
ATOM   2110 O O   . MET A 1 291 ? 149.93201 -27.80750 2.67063   1.000 26.33867  ? 290 MET A O   1 
ATOM   2111 C CB  . MET A 1 291 ? 147.14635 -28.39217 2.11957   1.000 20.92664  ? 290 MET A CB  1 
ATOM   2112 C CG  . MET A 1 291 ? 145.85374 -27.97782 1.41510   1.000 25.21222  ? 290 MET A CG  1 
ATOM   2113 S SD  . MET A 1 291 ? 145.70814 -26.17753 1.42721   1.000 33.96578  ? 290 MET A SD  1 
ATOM   2114 C CE  . MET A 1 291 ? 145.35175 -25.99381 3.13669   1.000 47.11256  ? 290 MET A CE  1 
ATOM   2115 N N   . GLN A 1 292 ? 150.34797 -29.81632 1.75382   1.000 25.70456  ? 291 GLN A N   1 
ATOM   2116 C CA  . GLN A 1 292 ? 151.50359 -30.00986 2.60932   1.000 29.43702  ? 291 GLN A CA  1 
ATOM   2117 C C   . GLN A 1 292 ? 152.70647 -29.22397 2.08361   1.000 30.89371  ? 291 GLN A C   1 
ATOM   2118 O O   . GLN A 1 292 ? 152.78270 -28.85926 0.90231   1.000 26.51101  ? 291 GLN A O   1 
ATOM   2119 C CB  . GLN A 1 292 ? 151.80016 -31.50323 2.73349   1.000 32.09044  ? 291 GLN A CB  1 
ATOM   2120 C CG  . GLN A 1 292 ? 150.57640 -32.26980 3.30642   1.000 37.65552  ? 291 GLN A CG  1 
ATOM   2121 C CD  . GLN A 1 292 ? 149.92531 -31.56027 4.52290   1.000 43.22706  ? 291 GLN A CD  1 
ATOM   2122 O OE1 . GLN A 1 292 ? 150.57617 -31.36317 5.55729   1.000 42.67004  ? 291 GLN A OE1 1 
ATOM   2123 N NE2 . GLN A 1 292 ? 148.63459 -31.17839 4.39478   1.000 26.74386  ? 291 GLN A NE2 1 
ATOM   2124 N N   . ASP A 1 293 ? 153.62727 -28.92414 3.00510   1.000 27.25061  ? 292 ASP A N   1 
ATOM   2125 C CA  . ASP A 1 293 ? 154.88587 -28.23319 2.70289   1.000 32.03182  ? 292 ASP A CA  1 
ATOM   2126 C C   . ASP A 1 293 ? 154.65733 -26.81881 2.16493   1.000 29.91737  ? 292 ASP A C   1 
ATOM   2127 O O   . ASP A 1 293 ? 155.31722 -26.38423 1.21967   1.000 26.89703  ? 292 ASP A O   1 
ATOM   2128 C CB  . ASP A 1 293 ? 155.74140 -29.04537 1.73183   1.000 34.83148  ? 292 ASP A CB  1 
ATOM   2129 C CG  . ASP A 1 293 ? 156.21253 -30.34903 2.33604   1.000 46.84065  ? 292 ASP A CG  1 
ATOM   2130 O OD1 . ASP A 1 293 ? 156.68972 -30.32543 3.48927   1.000 52.44348  ? 292 ASP A OD1 1 
ATOM   2131 O OD2 . ASP A 1 293 ? 156.09111 -31.39648 1.66880   1.000 55.07478  ? 292 ASP A OD2 1 
ATOM   2132 N N   . VAL A 1 294 ? 153.74940 -26.07656 2.80053   1.000 24.13087  ? 293 VAL A N   1 
ATOM   2133 C CA  . VAL A 1 294 ? 153.44425 -24.72275 2.34325   1.000 20.81097  ? 293 VAL A CA  1 
ATOM   2134 C C   . VAL A 1 294 ? 154.65373 -23.81050 2.55475   1.000 23.32890  ? 293 VAL A C   1 
ATOM   2135 O O   . VAL A 1 294 ? 155.44431 -23.97676 3.50154   1.000 25.98067  ? 293 VAL A O   1 
ATOM   2136 C CB  . VAL A 1 294 ? 152.20326 -24.17917 3.07920   1.000 22.73887  ? 293 VAL A CB  1 
ATOM   2137 C CG1 . VAL A 1 294 ? 152.51028 -24.00691 4.56739   1.000 23.44820  ? 293 VAL A CG1 1 
ATOM   2138 C CG2 . VAL A 1 294 ? 151.75556 -22.85325 2.47462   1.000 25.02595  ? 293 VAL A CG2 1 
ATOM   2139 N N   . LEU A 1 295 ? 154.82350 -22.85774 1.64580   1.000 23.52585  ? 294 LEU A N   1 
ATOM   2140 C CA  . LEU A 1 295 ? 155.85055 -21.83829 1.80810   1.000 25.02714  ? 294 LEU A CA  1 
ATOM   2141 C C   . LEU A 1 295 ? 155.47029 -20.88153 2.92780   1.000 24.38375  ? 294 LEU A C   1 
ATOM   2142 O O   . LEU A 1 295 ? 154.29419 -20.63555 3.18215   1.000 25.70642  ? 294 LEU A O   1 
ATOM   2143 C CB  . LEU A 1 295 ? 156.02192 -21.01939 0.52363   1.000 21.48872  ? 294 LEU A CB  1 
ATOM   2144 C CG  . LEU A 1 295 ? 156.53556 -21.68122 -0.75451  1.000 25.88875  ? 294 LEU A CG  1 
ATOM   2145 C CD1 . LEU A 1 295 ? 156.53618 -20.64637 -1.88319  1.000 29.77234  ? 294 LEU A CD1 1 
ATOM   2146 C CD2 . LEU A 1 295 ? 157.92629 -22.24073 -0.53860  1.000 28.49618  ? 294 LEU A CD2 1 
ATOM   2147 N N   . LEU A 1 296 ? 156.48346 -20.30191 3.55806   1.000 24.24919  ? 295 LEU A N   1 
ATOM   2148 C CA  . LEU A 1 296 ? 156.26271 -19.20179 4.47834   1.000 25.69895  ? 295 LEU A CA  1 
ATOM   2149 C C   . LEU A 1 296 ? 155.90105 -17.94309 3.69412   1.000 25.76630  ? 295 LEU A C   1 
ATOM   2150 O O   . LEU A 1 296 ? 156.22675 -17.82591 2.50749   1.000 25.75295  ? 295 LEU A O   1 
ATOM   2151 C CB  . LEU A 1 296 ? 157.51319 -18.94995 5.31760   1.000 26.32696  ? 295 LEU A CB  1 
ATOM   2152 C CG  . LEU A 1 296 ? 158.15696 -20.11894 6.07797   1.000 32.98130  ? 295 LEU A CG  1 
ATOM   2153 C CD1 . LEU A 1 296 ? 159.35539 -19.62461 6.87030   1.000 34.22044  ? 295 LEU A CD1 1 
ATOM   2154 C CD2 . LEU A 1 296 ? 157.16752 -20.85582 6.99993   1.000 28.73884  ? 295 LEU A CD2 1 
ATOM   2155 N N   . PRO A 1 297 ? 155.23501 -16.97720 4.33495   1.000 29.01770  ? 296 PRO A N   1 
ATOM   2156 C CA  . PRO A 1 297 ? 154.92256 -15.72657 3.61330   1.000 27.69922  ? 296 PRO A CA  1 
ATOM   2157 C C   . PRO A 1 297 ? 156.15399 -15.04079 3.04131   1.000 29.24056  ? 296 PRO A C   1 
ATOM   2158 O O   . PRO A 1 297 ? 156.14407 -14.62635 1.87205   1.000 25.89641  ? 296 PRO A O   1 
ATOM   2159 C CB  . PRO A 1 297 ? 154.22546 -14.87553 4.68654   1.000 29.03791  ? 296 PRO A CB  1 
ATOM   2160 C CG  . PRO A 1 297 ? 153.59930 -15.91563 5.62604   1.000 29.12521  ? 296 PRO A CG  1 
ATOM   2161 C CD  . PRO A 1 297 ? 154.64933 -16.99752 5.69224   1.000 28.89328  ? 296 PRO A CD  1 
ATOM   2162 N N   . GLN A 1 298 ? 157.23150 -14.93283 3.82648   1.000 27.64583  ? 297 GLN A N   1 
ATOM   2163 C CA  . GLN A 1 298 ? 158.43810 -14.27293 3.33128   1.000 26.28110  ? 297 GLN A CA  1 
ATOM   2164 C C   . GLN A 1 298 ? 159.02483 -15.01326 2.13229   1.000 33.74490  ? 297 GLN A C   1 
ATOM   2165 O O   . GLN A 1 298 ? 159.44613 -14.38323 1.15180   1.000 32.64932  ? 297 GLN A O   1 
ATOM   2166 C CB  . GLN A 1 298 ? 159.47114 -14.15114 4.45941   1.000 37.53152  ? 297 GLN A CB  1 
ATOM   2167 N N   . GLU A 1 299 ? 159.06691 -16.35139 2.19208   1.000 29.94708  ? 298 GLU A N   1 
ATOM   2168 C CA  . GLU A 1 299 ? 159.50392 -17.13242 1.03662   1.000 32.77578  ? 298 GLU A CA  1 
ATOM   2169 C C   . GLU A 1 299 ? 158.59081 -16.89265 -0.15843  1.000 31.23002  ? 298 GLU A C   1 
ATOM   2170 O O   . GLU A 1 299 ? 159.05476 -16.80176 -1.30511  1.000 28.02252  ? 298 GLU A O   1 
ATOM   2171 C CB  . GLU A 1 299 ? 159.52398 -18.62680 1.37427   1.000 29.40373  ? 298 GLU A CB  1 
ATOM   2172 C CG  . GLU A 1 299 ? 160.53294 -19.04247 2.44056   1.000 31.05008  ? 298 GLU A CG  1 
ATOM   2173 C CD  . GLU A 1 299 ? 160.30161 -20.46733 2.93841   1.000 32.73894  ? 298 GLU A CD  1 
ATOM   2174 O OE1 . GLU A 1 299 ? 159.19023 -21.01220 2.72770   1.000 28.19895  ? 298 GLU A OE1 1 
ATOM   2175 O OE2 . GLU A 1 299 ? 161.22089 -21.03524 3.56717   1.000 39.05345  ? 298 GLU A OE2 1 
ATOM   2176 N N   . THR A 1 300 ? 157.28284 -16.82281 0.08834   1.000 24.32580  ? 299 THR A N   1 
ATOM   2177 C CA  . THR A 1 300 ? 156.34068 -16.58786 -0.99857  1.000 26.81505  ? 299 THR A CA  1 
ATOM   2178 C C   . THR A 1 300 ? 156.63409 -15.25871 -1.68785  1.000 28.42980  ? 299 THR A C   1 
ATOM   2179 O O   . THR A 1 300 ? 156.63689 -15.17403 -2.92029  1.000 27.01298  ? 299 THR A O   1 
ATOM   2180 C CB  . THR A 1 300 ? 154.90288 -16.62246 -0.46461  1.000 24.86150  ? 299 THR A CB  1 
ATOM   2181 O OG1 . THR A 1 300 ? 154.62050 -17.90447 0.12755   1.000 24.48685  ? 299 THR A OG1 1 
ATOM   2182 C CG2 . THR A 1 300 ? 153.91088 -16.38656 -1.59925  1.000 24.00014  ? 299 THR A CG2 1 
ATOM   2183 N N   . ALA A 1 301 ? 156.90578 -14.21486 -0.90335  1.000 27.66381  ? 300 ALA A N   1 
ATOM   2184 C CA  . ALA A 1 301 ? 157.21981 -12.90995 -1.47513  1.000 28.82270  ? 300 ALA A CA  1 
ATOM   2185 C C   . ALA A 1 301 ? 158.51168 -12.95744 -2.28264  1.000 32.89844  ? 300 ALA A C   1 
ATOM   2186 O O   . ALA A 1 301 ? 158.57585 -12.43412 -3.39916  1.000 32.88890  ? 300 ALA A O   1 
ATOM   2187 C CB  . ALA A 1 301 ? 157.32243 -11.86252 -0.36630  1.000 32.46975  ? 300 ALA A CB  1 
ATOM   2188 N N   . GLU A 1 302 ? 159.55763 -13.57795 -1.72906  1.000 32.84510  ? 301 GLU A N   1 
ATOM   2189 C CA  . GLU A 1 302 ? 160.86066 -13.55102 -2.39160  1.000 34.80275  ? 301 GLU A CA  1 
ATOM   2190 C C   . GLU A 1 302 ? 160.84600 -14.35897 -3.68206  1.000 34.65580  ? 301 GLU A C   1 
ATOM   2191 O O   . GLU A 1 302 ? 161.44581 -13.94798 -4.68167  1.000 33.42476  ? 301 GLU A O   1 
ATOM   2192 C CB  . GLU A 1 302 ? 161.94298 -14.05636 -1.43939  1.000 33.88686  ? 301 GLU A CB  1 
ATOM   2193 C CG  . GLU A 1 302 ? 162.20493 -13.07177 -0.30411  1.000 38.88121  ? 301 GLU A CG  1 
ATOM   2194 C CD  . GLU A 1 302 ? 163.07062 -13.64360 0.80209   1.000 54.39405  ? 301 GLU A CD  1 
ATOM   2195 O OE1 . GLU A 1 302 ? 163.39776 -14.85131 0.74931   1.000 54.24665  ? 301 GLU A OE1 1 
ATOM   2196 O OE2 . GLU A 1 302 ? 163.41672 -12.87686 1.72859   1.000 47.81943  ? 301 GLU A OE2 1 
ATOM   2197 N N   . ILE A 1 303 ? 160.13841 -15.49048 -3.69173  1.000 31.16397  ? 302 ILE A N   1 
ATOM   2198 C CA  . ILE A 1 303 ? 160.12451 -16.35573 -4.86922  1.000 31.04085  ? 302 ILE A CA  1 
ATOM   2199 C C   . ILE A 1 303 ? 159.16415 -15.83909 -5.93213  1.000 34.04291  ? 302 ILE A C   1 
ATOM   2200 O O   . ILE A 1 303 ? 159.48167 -15.85448 -7.12764  1.000 32.75878  ? 302 ILE A O   1 
ATOM   2201 C CB  . ILE A 1 303 ? 159.77300 -17.79676 -4.45785  1.000 32.27372  ? 302 ILE A CB  1 
ATOM   2202 C CG1 . ILE A 1 303 ? 160.85956 -18.36604 -3.54513  1.000 31.01689  ? 302 ILE A CG1 1 
ATOM   2203 C CG2 . ILE A 1 303 ? 159.59029 -18.66689 -5.69164  1.000 31.52005  ? 302 ILE A CG2 1 
ATOM   2204 C CD1 . ILE A 1 303 ? 160.45845 -19.65784 -2.86445  1.000 39.57435  ? 302 ILE A CD1 1 
ATOM   2205 N N   . HIS A 1 304 ? 157.97189 -15.39230 -5.52999  1.000 28.80041  ? 303 HIS A N   1 
ATOM   2206 C CA  . HIS A 1 304 ? 156.88143 -15.17213 -6.46893  1.000 29.95260  ? 303 HIS A CA  1 
ATOM   2207 C C   . HIS A 1 304 ? 156.43516 -13.72978 -6.61292  1.000 31.81383  ? 303 HIS A C   1 
ATOM   2208 O O   . HIS A 1 304 ? 155.78808 -13.41057 -7.61676  1.000 33.22545  ? 303 HIS A O   1 
ATOM   2209 C CB  . HIS A 1 304 ? 155.65005 -15.99914 -6.06814  1.000 26.63626  ? 303 HIS A CB  1 
ATOM   2210 C CG  . HIS A 1 304 ? 155.85554 -17.47959 -6.15982  1.000 28.20972  ? 303 HIS A CG  1 
ATOM   2211 N ND1 . HIS A 1 304 ? 155.80889 -18.16423 -7.35483  1.000 29.79918  ? 303 HIS A ND1 1 
ATOM   2212 C CD2 . HIS A 1 304 ? 156.09622 -18.40672 -5.20332  1.000 26.61722  ? 303 HIS A CD2 1 
ATOM   2213 C CE1 . HIS A 1 304 ? 156.02200 -19.44983 -7.13015  1.000 27.75961  ? 303 HIS A CE1 1 
ATOM   2214 N NE2 . HIS A 1 304 ? 156.19898 -19.62346 -5.83281  1.000 28.39529  ? 303 HIS A NE2 1 
ATOM   2215 N N   . LEU A 1 305 ? 156.73118 -12.85792 -5.65079  1.000 29.74288  ? 304 LEU A N   1 
ATOM   2216 C CA  . LEU A 1 305 ? 156.18030 -11.50919 -5.66005  1.000 31.17972  ? 304 LEU A CA  1 
ATOM   2217 C C   . LEU A 1 305 ? 157.22037 -10.41292 -5.83461  1.000 42.78336  ? 304 LEU A C   1 
ATOM   2218 O O   . LEU A 1 305 ? 156.89114 -9.36045  -6.38077  1.000 43.11718  ? 304 LEU A O   1 
ATOM   2219 C CB  . LEU A 1 305 ? 155.39629 -11.24357 -4.36997  1.000 32.85116  ? 304 LEU A CB  1 
ATOM   2220 C CG  . LEU A 1 305 ? 154.37387 -12.32474 -4.01261  1.000 28.61434  ? 304 LEU A CG  1 
ATOM   2221 C CD1 . LEU A 1 305 ? 153.69138 -12.03021 -2.66756  1.000 29.24593  ? 304 LEU A CD1 1 
ATOM   2222 C CD2 . LEU A 1 305 ? 153.33036 -12.48240 -5.13208  1.000 27.37263  ? 304 LEU A CD2 1 
ATOM   2223 N N   . HIS A 1 306 ? 158.45192 -10.61588 -5.37756  1.000 40.20525  ? 305 HIS A N   1 
ATOM   2224 C CA  . HIS A 1 306 ? 159.47187 -9.57985  -5.50181  1.000 45.81817  ? 305 HIS A CA  1 
ATOM   2225 C C   . HIS A 1 306 ? 160.00358 -9.54771  -6.93177  1.000 43.92011  ? 305 HIS A C   1 
ATOM   2226 O O   . HIS A 1 306 ? 159.96786 -8.50753  -7.58363  1.000 57.89083  ? 305 HIS A O   1 
ATOM   2227 C CB  . HIS A 1 306 ? 160.62079 -9.80201  -4.51332  1.000 41.60886  ? 305 HIS A CB  1 
ATOM   2228 C CG  . HIS A 1 306 ? 160.25095 -9.56054  -3.08031  1.000 49.22565  ? 305 HIS A CG  1 
ATOM   2229 N ND1 . HIS A 1 306 ? 161.12571 -9.78801  -2.03847  1.000 42.98672  ? 305 HIS A ND1 1 
ATOM   2230 C CD2 . HIS A 1 306 ? 159.10085 -9.11776  -2.51540  1.000 44.74397  ? 305 HIS A CD2 1 
ATOM   2231 C CE1 . HIS A 1 306 ? 160.52994 -9.49667  -0.89495  1.000 43.03701  ? 305 HIS A CE1 1 
ATOM   2232 N NE2 . HIS A 1 306 ? 159.30313 -9.08379  -1.15734  1.000 40.64799  ? 305 HIS A NE2 1 
ATOM   2233 N N   . ARG B 2 2   ? 138.68036 -16.09471 -22.98141 1.000 62.87236  ? 2   ARG B N   1 
ATOM   2234 C CA  . ARG B 2 2   ? 137.31104 -15.70602 -22.65123 1.000 69.79255  ? 2   ARG B CA  1 
ATOM   2235 C C   . ARG B 2 2   ? 137.30730 -14.61340 -21.57754 1.000 65.46931  ? 2   ARG B C   1 
ATOM   2236 O O   . ARG B 2 2   ? 138.32780 -14.37308 -20.92240 1.000 59.90619  ? 2   ARG B O   1 
ATOM   2237 C CB  . ARG B 2 2   ? 136.50502 -16.92076 -22.18660 1.000 61.16762  ? 2   ARG B CB  1 
ATOM   2238 C CG  . ARG B 2 2   ? 137.03178 -17.53938 -20.91519 1.000 52.19366  ? 2   ARG B CG  1 
ATOM   2239 C CD  . ARG B 2 2   ? 136.30445 -18.82833 -20.57231 1.000 47.88808  ? 2   ARG B CD  1 
ATOM   2240 N NE  . ARG B 2 2   ? 136.50941 -19.85803 -21.58220 1.000 40.78410  ? 2   ARG B NE  1 
ATOM   2241 C CZ  . ARG B 2 2   ? 137.60364 -20.60052 -21.69024 1.000 43.65166  ? 2   ARG B CZ  1 
ATOM   2242 N NH1 . ARG B 2 2   ? 138.62048 -20.46377 -20.85055 1.000 41.81090  ? 2   ARG B NH1 1 
ATOM   2243 N NH2 . ARG B 2 2   ? 137.68148 -21.50020 -22.66830 1.000 36.03930  ? 2   ARG B NH2 1 
ATOM   2244 N N   . LYS B 2 3   ? 136.15792 -13.96413 -21.38708 1.000 55.30417  ? 3   LYS B N   1 
ATOM   2245 C CA  . LYS B 2 3   ? 136.10572 -12.74312 -20.59179 1.000 43.90071  ? 3   LYS B CA  1 
ATOM   2246 C C   . LYS B 2 3   ? 136.04977 -13.07337 -19.10230 1.000 42.89684  ? 3   LYS B C   1 
ATOM   2247 O O   . LYS B 2 3   ? 135.09334 -13.68592 -18.61891 1.000 53.52739  ? 3   LYS B O   1 
ATOM   2248 C CB  . LYS B 2 3   ? 134.91144 -11.88228 -20.99356 1.000 39.93004  ? 3   LYS B CB  1 
ATOM   2249 N N   . ARG B 2 4   ? 137.06270 -12.64066 -18.37863 1.000 32.54858  ? 4   ARG B N   1 
ATOM   2250 C CA  . ARG B 2 4   ? 137.06036 -12.69726 -16.92492 1.000 27.44385  ? 4   ARG B CA  1 
ATOM   2251 C C   . ARG B 2 4   ? 136.52762 -11.37761 -16.39009 1.000 30.56268  ? 4   ARG B C   1 
ATOM   2252 O O   . ARG B 2 4   ? 136.87798 -10.30771 -16.89732 1.000 31.66853  ? 4   ARG B O   1 
ATOM   2253 C CB  . ARG B 2 4   ? 138.47676 -12.96132 -16.42793 1.000 28.43028  ? 4   ARG B CB  1 
ATOM   2254 C CG  . ARG B 2 4   ? 138.71076 -12.78115 -14.93824 1.000 23.93272  ? 4   ARG B CG  1 
ATOM   2255 C CD  . ARG B 2 4   ? 140.15657 -13.14536 -14.64218 1.000 23.01304  ? 4   ARG B CD  1 
ATOM   2256 N NE  . ARG B 2 4   ? 140.58539 -12.67557 -13.32715 1.000 22.46956  ? 4   ARG B NE  1 
ATOM   2257 C CZ  . ARG B 2 4   ? 140.31167 -13.30953 -12.19600 1.000 26.70492  ? 4   ARG B CZ  1 
ATOM   2258 N NH1 . ARG B 2 4   ? 139.56071 -14.40129 -12.18308 1.000 24.24767  ? 4   ARG B NH1 1 
ATOM   2259 N NH2 . ARG B 2 4   ? 140.82999 -12.85839 -11.05590 1.000 22.35534  ? 4   ARG B NH2 1 
ATOM   2260 N N   . ARG B 2 5   ? 135.64414 -11.44968 -15.39570 1.000 26.99377  ? 5   ARG B N   1 
ATOM   2261 C CA  . ARG B 2 5   ? 135.03045 -10.23625 -14.87807 1.000 27.60845  ? 5   ARG B CA  1 
ATOM   2262 C C   . ARG B 2 5   ? 134.86021 -10.32789 -13.37010 1.000 27.47965  ? 5   ARG B C   1 
ATOM   2263 O O   . ARG B 2 5   ? 134.80366 -11.41242 -12.78662 1.000 25.72958  ? 5   ARG B O   1 
ATOM   2264 C CB  . ARG B 2 5   ? 133.66969 -9.96367  -15.53349 1.000 29.29589  ? 5   ARG B CB  1 
ATOM   2265 C CG  . ARG B 2 5   ? 132.57990 -10.97402 -15.18929 1.000 35.40134  ? 5   ARG B CG  1 
ATOM   2266 C CD  . ARG B 2 5   ? 131.29066 -10.63422 -15.95669 1.000 46.59039  ? 5   ARG B CD  1 
ATOM   2267 N NE  . ARG B 2 5   ? 130.09980 -11.26596 -15.39444 1.000 52.73864  ? 5   ARG B NE  1 
ATOM   2268 C CZ  . ARG B 2 5   ? 129.37253 -10.76600 -14.40004 1.000 51.03088  ? 5   ARG B CZ  1 
ATOM   2269 N NH1 . ARG B 2 5   ? 129.70186 -9.63151  -13.79273 1.000 41.99239  ? 5   ARG B NH1 1 
ATOM   2270 N N   . ARG B 2 6   ? 134.78515 -9.15845  -12.74701 1.000 26.25118  ? 6   ARG B N   1 
ATOM   2271 C CA  . ARG B 2 6   ? 134.34307 -9.07917  -11.36356 1.000 26.11970  ? 6   ARG B CA  1 
ATOM   2272 C C   . ARG B 2 6   ? 132.84234 -9.35425  -11.28745 1.000 28.25612  ? 6   ARG B C   1 
ATOM   2273 O O   . ARG B 2 6   ? 132.14043 -9.30224  -12.29826 1.000 27.67348  ? 6   ARG B O   1 
ATOM   2274 C CB  . ARG B 2 6   ? 134.66550 -7.69451  -10.79125 1.000 29.25668  ? 6   ARG B CB  1 
ATOM   2275 C CG  . ARG B 2 6   ? 136.16577 -7.39094  -10.69740 1.000 28.10915  ? 6   ARG B CG  1 
ATOM   2276 C CD  . ARG B 2 6   ? 136.41777 -5.96528  -10.18524 1.000 33.12014  ? 6   ARG B CD  1 
ATOM   2277 N NE  . ARG B 2 6   ? 137.83633 -5.70977  -9.94927  1.000 28.38999  ? 6   ARG B NE  1 
ATOM   2278 C CZ  . ARG B 2 6   ? 138.43475 -5.82314  -8.76894  1.000 32.98260  ? 6   ARG B CZ  1 
ATOM   2279 N NH1 . ARG B 2 6   ? 137.76424 -6.17633  -7.68086  1.000 30.83092  ? 6   ARG B NH1 1 
ATOM   2280 N NH2 . ARG B 2 6   ? 139.74127 -5.58138  -8.67761  1.000 31.29967  ? 6   ARG B NH2 1 
ATOM   2281 N N   . HIS B 2 7   ? 132.36879 -9.66279  -10.08699 1.000 26.84248  ? 7   HIS B N   1 
ATOM   2282 C CA  . HIS B 2 7   ? 130.95609 -9.94866  -9.84492  1.000 27.71063  ? 7   HIS B CA  1 
ATOM   2283 C C   . HIS B 2 7   ? 130.51233 -9.18793  -8.60283  1.000 30.28287  ? 7   HIS B C   1 
ATOM   2284 O O   . HIS B 2 7   ? 130.90430 -9.56737  -7.48124  1.000 32.94840  ? 7   HIS B O   1 
ATOM   2285 C CB  . HIS B 2 7   ? 130.71416 -11.44349 -9.65470  1.000 27.34426  ? 7   HIS B CB  1 
ATOM   2286 C CG  . HIS B 2 7   ? 131.14886 -12.27933 -10.81535 1.000 28.30589  ? 7   HIS B CG  1 
ATOM   2287 N ND1 . HIS B 2 7   ? 132.44908 -12.70796 -10.97884 1.000 26.53377  ? 7   HIS B ND1 1 
ATOM   2288 C CD2 . HIS B 2 7   ? 130.45285 -12.77206 -11.86714 1.000 27.80893  ? 7   HIS B CD2 1 
ATOM   2289 C CE1 . HIS B 2 7   ? 132.53660 -13.42152 -12.08887 1.000 30.10783  ? 7   HIS B CE1 1 
ATOM   2290 N NE2 . HIS B 2 7   ? 131.33980 -13.47725 -12.64562 1.000 27.32761  ? 7   HIS B NE2 1 
ATOM   2291 N N   . PRO B 2 8   ? 129.69885 -8.15167  -8.74563  1.000 33.83140  ? 8   PRO B N   1 
ATOM   2292 C CA  . PRO B 2 8   ? 129.28228 -7.37272  -7.57620  1.000 35.97771  ? 8   PRO B CA  1 
ATOM   2293 C C   . PRO B 2 8   ? 128.55030 -8.20817  -6.53728  1.000 38.20201  ? 8   PRO B C   1 
ATOM   2294 O O   . PRO B 2 8   ? 127.88553 -9.19982  -6.84651  1.000 38.26055  ? 8   PRO B O   1 
ATOM   2295 C CB  . PRO B 2 8   ? 128.36490 -6.30200  -8.17940  1.000 40.78314  ? 8   PRO B CB  1 
ATOM   2296 C CG  . PRO B 2 8   ? 128.89773 -6.10697  -9.56294  1.000 42.80634  ? 8   PRO B CG  1 
ATOM   2297 C CD  . PRO B 2 8   ? 129.34450 -7.48331  -10.01255 1.000 38.53574  ? 8   PRO B CD  1 
ATOM   2298 N N   . SER B 2 9   ? 128.71550 -7.79937  -5.27938  1.000 36.41613  ? 9   SER B N   1 
ATOM   2299 C CA  . SER B 2 9   ? 127.96790 -8.31903  -4.13984  1.000 38.47380  ? 9   SER B CA  1 
ATOM   2300 C C   . SER B 2 9   ? 127.41947 -7.16317  -3.31310  1.000 55.70069  ? 9   SER B C   1 
ATOM   2301 O O   . SER B 2 9   ? 127.48750 -6.00385  -3.73968  1.000 58.43015  ? 9   SER B O   1 
ATOM   2302 C CB  . SER B 2 9   ? 128.85698 -9.18525  -3.26115  1.000 43.41749  ? 9   SER B CB  1 
ATOM   2303 O OG  . SER B 2 9   ? 130.01977 -8.47008  -2.87970  1.000 45.40757  ? 9   SER B OG  1 
ATOM   2304 N N   . GLY B 2 10  ? 126.91093 -7.46638  -2.11953  1.000 55.48790  ? 10  GLY B N   1 
ATOM   2305 C CA  . GLY B 2 10  ? 126.43140 -6.45629  -1.18957  1.000 52.92657  ? 10  GLY B CA  1 
ATOM   2306 C C   . GLY B 2 10  ? 125.36926 -5.53508  -1.75327  1.000 58.62269  ? 10  GLY B C   1 
ATOM   2307 O O   . GLY B 2 10  ? 124.17719 -5.74626  -1.54706  1.000 61.76828  ? 10  GLY B O   1 
HETATM 2308 C C1  . GOL C 3 .   ? 139.62570 -4.22102  -3.67648  0.815 30.09796  ? 401 GOL A C1  1 
HETATM 2309 O O1  . GOL C 3 .   ? 140.48771 -3.81967  -4.75002  0.815 29.62444  ? 401 GOL A O1  1 
HETATM 2310 C C2  . GOL C 3 .   ? 138.31564 -4.71691  -4.33997  0.815 29.24243  ? 401 GOL A C2  1 
HETATM 2311 O O2  . GOL C 3 .   ? 138.50853 -5.88190  -5.03902  0.815 29.59291  ? 401 GOL A O2  1 
HETATM 2312 C C3  . GOL C 3 .   ? 137.26646 -4.87122  -3.21191  0.815 42.31739  ? 401 GOL A C3  1 
HETATM 2313 O O3  . GOL C 3 .   ? 136.05642 -5.22090  -3.84883  0.815 44.37395  ? 401 GOL A O3  1 
HETATM 2314 C C1  . GOL D 3 .   ? 131.29553 -25.41288 -16.17940 0.772 34.38279  ? 402 GOL A C1  1 
HETATM 2315 O O1  . GOL D 3 .   ? 130.44397 -26.23213 -15.43320 0.772 35.86129  ? 402 GOL A O1  1 
HETATM 2316 C C2  . GOL D 3 .   ? 132.68349 -25.52717 -15.52804 0.772 31.66816  ? 402 GOL A C2  1 
HETATM 2317 O O2  . GOL D 3 .   ? 133.00045 -26.83323 -15.18626 0.772 31.17714  ? 402 GOL A O2  1 
HETATM 2318 C C3  . GOL D 3 .   ? 133.66619 -24.91986 -16.55172 0.772 36.03070  ? 402 GOL A C3  1 
HETATM 2319 O O3  . GOL D 3 .   ? 134.91902 -24.87820 -15.92514 0.772 31.80676  ? 402 GOL A O3  1 
HETATM 2320 C C4  . 8UB E 4 .   ? 137.91685 -1.91322  -0.17902  0.931 31.73137  ? 403 8UB A C4  1 
HETATM 2321 C C5  . 8UB E 4 .   ? 137.07510 -1.91936  -1.28419  0.931 35.97787  ? 403 8UB A C5  1 
HETATM 2322 C C6  . 8UB E 4 .   ? 138.24782 -2.35012  2.18837   0.931 34.04386  ? 403 8UB A C6  1 
HETATM 2323 N N1  . 8UB E 4 .   ? 140.10197 -1.46424  0.78444   0.931 34.73482  ? 403 8UB A N1  1 
HETATM 2324 C C7  . 8UB E 4 .   ? 139.67562 -1.90554  1.94202   0.931 35.41116  ? 403 8UB A C7  1 
HETATM 2325 C C8  . 8UB E 4 .   ? 140.60224 -2.00717  3.00742   0.931 33.22649  ? 403 8UB A C8  1 
HETATM 2326 O O   . 8UB E 4 .   ? 137.81114 -2.69741  3.28237   0.931 35.39518  ? 403 8UB A O   1 
HETATM 2327 N N   . 8UB E 4 .   ? 137.47775 -2.33816  1.07424   0.931 32.51610  ? 403 8UB A N   1 
HETATM 2328 C C   . 8UB E 4 .   ? 137.53673 -1.42138  -2.49330  0.931 36.49985  ? 403 8UB A C   1 
HETATM 2329 C C3  . 8UB E 4 .   ? 139.23325 -1.44310  -0.28754  0.931 32.22186  ? 403 8UB A C3  1 
HETATM 2330 C C2  . 8UB E 4 .   ? 139.67450 -0.93325  -1.51158  0.931 31.58584  ? 403 8UB A C2  1 
HETATM 2331 C C1  . 8UB E 4 .   ? 138.82000 -0.92040  -2.60111  0.931 31.21955  ? 403 8UB A C1  1 
HETATM 2332 C C9  . 8UB E 4 .   ? 141.91680 -1.83434  3.03518   0.931 32.42483  ? 403 8UB A C9  1 
HETATM 2333 C C10 . 8UB E 4 .   ? 143.03965 -1.52964  2.17621   0.931 33.35048  ? 403 8UB A C10 1 
HETATM 2334 C C11 . 8UB E 4 .   ? 144.35899 -1.60641  2.54861   0.931 33.68508  ? 403 8UB A C11 1 
HETATM 2335 C C12 . 8UB E 4 .   ? 145.23005 -1.34332  1.45682   0.931 39.03829  ? 403 8UB A C12 1 
HETATM 2336 C C13 . 8UB E 4 .   ? 144.56703 -1.05146  0.31570   0.931 36.11030  ? 403 8UB A C13 1 
HETATM 2337 S S1  . 8UB E 4 .   ? 142.88540 -1.08840  0.51203   0.931 40.39777  ? 403 8UB A S1  1 
HETATM 2338 O O   A HOH F 5 .   ? 134.43845 -6.05391  -2.05279  0.527 26.89938  ? 501 HOH A O   1 
HETATM 2339 O O   B HOH F 5 .   ? 132.50520 -6.71868  -1.82508  0.473 29.38449  ? 501 HOH A O   1 
HETATM 2340 O O   . HOH F 5 .   ? 146.267   -22.503   -21.114   1.000 43.21039  ? 502 HOH A O   1 
HETATM 2341 O O   . HOH F 5 .   ? 140.94290 7.46968   14.86783  1.000 54.76638  ? 503 HOH A O   1 
HETATM 2342 O O   . HOH F 5 .   ? 157.18868 -25.73943 -2.76089  1.000 36.17695  ? 504 HOH A O   1 
HETATM 2343 O O   . HOH F 5 .   ? 162.98790 -19.59997 4.51297   1.000 45.39013  ? 505 HOH A O   1 
HETATM 2344 O O   . HOH F 5 .   ? 148.58782 -32.10897 8.25460   1.000 39.86206  ? 506 HOH A O   1 
HETATM 2345 O O   . HOH F 5 .   ? 148.63692 -33.60586 -16.25193 1.000 31.73209  ? 507 HOH A O   1 
HETATM 2346 O O   . HOH F 5 .   ? 142.04335 -16.73087 15.85912  1.000 45.59375  ? 508 HOH A O   1 
HETATM 2347 O O   . HOH F 5 .   ? 138.91670 -37.22537 6.22793   1.000 46.91369  ? 509 HOH A O   1 
HETATM 2348 O O   . HOH F 5 .   ? 124.34913 -6.89364  3.22896   1.000 55.63284  ? 510 HOH A O   1 
HETATM 2349 O O   . HOH F 5 .   ? 118.11252 -15.95326 -5.37185  1.000 40.98638  ? 511 HOH A O   1 
HETATM 2350 O O   . HOH F 5 .   ? 134.79195 -4.91188  6.17192   1.000 26.00745  ? 512 HOH A O   1 
HETATM 2351 O O   . HOH F 5 .   ? 148.12939 0.50203   8.33402   1.000 37.72833  ? 513 HOH A O   1 
HETATM 2352 O O   . HOH F 5 .   ? 127.66709 -14.78414 -13.89974 1.000 33.06283  ? 514 HOH A O   1 
HETATM 2353 O O   . HOH F 5 .   ? 122.45248 -27.90416 -14.07493 1.000 40.21696  ? 515 HOH A O   1 
HETATM 2354 O O   . HOH F 5 .   ? 147.21664 -18.67399 11.82949  1.000 35.07820  ? 516 HOH A O   1 
HETATM 2355 O O   . HOH F 5 .   ? 131.10232 -2.26735  3.48988   1.000 42.05143  ? 517 HOH A O   1 
HETATM 2356 O O   . HOH F 5 .   ? 150.28049 -8.20615  -10.72874 1.000 46.02438  ? 518 HOH A O   1 
HETATM 2357 O O   . HOH F 5 .   ? 119.42756 -16.35233 8.13250   1.000 39.69819  ? 519 HOH A O   1 
HETATM 2358 O O   . HOH F 5 .   ? 139.81625 -10.57822 17.18232  1.000 44.56359  ? 520 HOH A O   1 
HETATM 2359 O O   . HOH F 5 .   ? 129.52232 4.91989   -1.92909  1.000 31.09189  ? 521 HOH A O   1 
HETATM 2360 O O   . HOH F 5 .   ? 140.07501 12.33745  -2.20102  1.000 49.79708  ? 522 HOH A O   1 
HETATM 2361 O O   . HOH F 5 .   ? 128.07950 -23.93540 10.20518  1.000 38.59025  ? 523 HOH A O   1 
HETATM 2362 O O   . HOH F 5 .   ? 150.67710 -6.96475  5.68400   1.000 39.18782  ? 524 HOH A O   1 
HETATM 2363 O O   . HOH F 5 .   ? 151.02068 -8.11289  8.74944   1.000 44.09866  ? 525 HOH A O   1 
HETATM 2364 O O   . HOH F 5 .   ? 131.16814 -8.28903  0.74214   1.000 36.37888  ? 526 HOH A O   1 
HETATM 2365 O O   . HOH F 5 .   ? 156.22070 -25.84527 5.18157   1.000 36.65375  ? 527 HOH A O   1 
HETATM 2366 O O   . HOH F 5 .   ? 128.51247 -27.84220 -13.41211 1.000 34.59981  ? 528 HOH A O   1 
HETATM 2367 O O   . HOH F 5 .   ? 125.30221 -25.49215 3.50342   1.000 22.62553  ? 529 HOH A O   1 
HETATM 2368 O O   . HOH F 5 .   ? 146.27741 -7.50491  9.68763   1.000 33.70833  ? 530 HOH A O   1 
HETATM 2369 O O   . HOH F 5 .   ? 137.63733 -32.59324 10.64440  1.000 35.16267  ? 531 HOH A O   1 
HETATM 2370 O O   . HOH F 5 .   ? 128.934   2.800     -3.713    1.000 35.45364  ? 532 HOH A O   1 
HETATM 2371 O O   . HOH F 5 .   ? 124.97310 -12.07932 3.08470   1.000 32.06149  ? 533 HOH A O   1 
HETATM 2372 O O   . HOH F 5 .   ? 113.80096 -24.02224 0.49183   1.000 44.72672  ? 534 HOH A O   1 
HETATM 2373 O O   . HOH F 5 .   ? 133.21235 -20.01590 16.90058  1.000 45.22182  ? 535 HOH A O   1 
HETATM 2374 O O   . HOH F 5 .   ? 148.53633 1.00934   -0.01526  1.000 38.50977  ? 536 HOH A O   1 
HETATM 2375 O O   . HOH F 5 .   ? 144.69224 -32.71057 12.43431  1.000 37.45892  ? 537 HOH A O   1 
HETATM 2376 O O   . HOH F 5 .   ? 132.15915 -19.93498 -10.06723 1.000 19.25015  ? 538 HOH A O   1 
HETATM 2377 O O   . HOH F 5 .   ? 148.13468 -23.67735 -12.14142 1.000 35.22399  ? 539 HOH A O   1 
HETATM 2378 O O   . HOH F 5 .   ? 143.14712 -9.44145  13.78694  1.000 33.19817  ? 540 HOH A O   1 
HETATM 2379 O O   . HOH F 5 .   ? 148.00676 -5.91734  12.48575  1.000 52.14372  ? 541 HOH A O   1 
HETATM 2380 O O   . HOH F 5 .   ? 134.25130 -12.10561 -8.86016  1.000 23.00676  ? 542 HOH A O   1 
HETATM 2381 O O   . HOH F 5 .   ? 147.73730 -13.84934 5.98969   1.000 24.19800  ? 543 HOH A O   1 
HETATM 2382 O O   . HOH F 5 .   ? 149.93313 -27.99995 -12.44342 1.000 37.12783  ? 544 HOH A O   1 
HETATM 2383 O O   . HOH F 5 .   ? 132.75149 -32.40615 -6.93857  1.000 43.36180  ? 545 HOH A O   1 
HETATM 2384 O O   . HOH F 5 .   ? 138.06749 -16.46239 -18.13818 1.000 33.19782  ? 546 HOH A O   1 
HETATM 2385 O O   . HOH F 5 .   ? 130.73551 9.96778   5.10387   1.000 30.69158  ? 547 HOH A O   1 
HETATM 2386 O O   . HOH F 5 .   ? 149.90187 -18.01712 -15.68166 1.000 41.95791  ? 548 HOH A O   1 
HETATM 2387 O O   . HOH F 5 .   ? 134.75272 -14.27999 -14.71495 1.000 30.08980  ? 549 HOH A O   1 
HETATM 2388 O O   . HOH F 5 .   ? 114.81486 -20.26398 2.56829   1.000 37.80051  ? 550 HOH A O   1 
HETATM 2389 O O   . HOH F 5 .   ? 122.45281 -11.03001 3.90785   1.000 40.78758  ? 551 HOH A O   1 
HETATM 2390 O O   . HOH F 5 .   ? 141.80177 -19.26884 -17.56860 1.000 39.31161  ? 552 HOH A O   1 
HETATM 2391 O O   . HOH F 5 .   ? 143.49915 -14.98099 -15.30644 1.000 26.58573  ? 553 HOH A O   1 
HETATM 2392 O O   . HOH F 5 .   ? 132.78205 -6.32994  -7.97042  1.000 31.89864  ? 554 HOH A O   1 
HETATM 2393 O O   . HOH F 5 .   ? 137.45864 10.27785  3.31350   1.000 42.39242  ? 555 HOH A O   1 
HETATM 2394 O O   . HOH F 5 .   ? 121.77165 -13.38945 8.73101   1.000 52.98568  ? 556 HOH A O   1 
HETATM 2395 O O   . HOH F 5 .   ? 149.29261 -35.92575 -15.07111 1.000 32.48590  ? 557 HOH A O   1 
HETATM 2396 O O   . HOH F 5 .   ? 153.49530 -30.11306 -1.40283  1.000 39.91631  ? 558 HOH A O   1 
HETATM 2397 O O   . HOH F 5 .   ? 122.47716 -29.48937 -7.05172  1.000 42.27285  ? 559 HOH A O   1 
HETATM 2398 O O   . HOH F 5 .   ? 147.435   -24.484   11.343    1.000 21.26490  ? 560 HOH A O   1 
HETATM 2399 O O   . HOH F 5 .   ? 154.88777 -25.53216 -1.33441  1.000 26.72517  ? 561 HOH A O   1 
HETATM 2400 O O   . HOH F 5 .   ? 128.21921 7.26137   17.44310  1.000 57.28999  ? 562 HOH A O   1 
HETATM 2401 O O   . HOH F 5 .   ? 133.84864 -34.08336 5.68004   1.000 44.18594  ? 563 HOH A O   1 
HETATM 2402 O O   . HOH F 5 .   ? 132.12177 -14.64196 -2.56234  1.000 20.94353  ? 564 HOH A O   1 
HETATM 2403 O O   . HOH F 5 .   ? 152.18681 -18.70922 3.10397   1.000 24.72198  ? 565 HOH A O   1 
HETATM 2404 O O   . HOH F 5 .   ? 130.72876 -30.52319 5.32663   1.000 29.38937  ? 566 HOH A O   1 
HETATM 2405 O O   . HOH F 5 .   ? 118.73145 -19.92339 12.06060  1.000 50.40977  ? 567 HOH A O   1 
HETATM 2406 O O   . HOH F 5 .   ? 149.65848 -0.22923  -3.21645  1.000 49.28690  ? 568 HOH A O   1 
HETATM 2407 O O   . HOH F 5 .   ? 136.32405 -13.86676 -9.08297  1.000 23.07781  ? 569 HOH A O   1 
HETATM 2408 O O   . HOH F 5 .   ? 129.50400 -19.89863 -0.68102  1.000 26.02618  ? 570 HOH A O   1 
HETATM 2409 O O   . HOH F 5 .   ? 137.42042 -4.51312  5.31870   1.000 29.59173  ? 571 HOH A O   1 
HETATM 2410 O O   . HOH F 5 .   ? 121.04063 7.83049   12.23089  1.000 55.15448  ? 572 HOH A O   1 
HETATM 2411 O O   . HOH F 5 .   ? 138.84035 -6.22699  6.76864   1.000 26.28447  ? 573 HOH A O   1 
HETATM 2412 O O   . HOH F 5 .   ? 117.98977 -18.98218 -6.47931  1.000 38.92722  ? 574 HOH A O   1 
HETATM 2413 O O   . HOH F 5 .   ? 142.24189 -34.57108 4.45344   1.000 30.87160  ? 575 HOH A O   1 
HETATM 2414 O O   . HOH F 5 .   ? 128.03055 -34.52565 -2.86392  1.000 29.72541  ? 576 HOH A O   1 
HETATM 2415 O O   . HOH F 5 .   ? 125.13107 -22.62757 10.04348  1.000 25.94265  ? 577 HOH A O   1 
HETATM 2416 O O   . HOH F 5 .   ? 155.53927 1.24593   -1.64243  1.000 57.43960  ? 578 HOH A O   1 
HETATM 2417 O O   . HOH F 5 .   ? 118.11986 -20.41868 -11.15814 1.000 48.70615  ? 579 HOH A O   1 
HETATM 2418 O O   . HOH F 5 .   ? 123.85216 -14.83594 12.42964  1.000 30.66438  ? 580 HOH A O   1 
HETATM 2419 O O   . HOH F 5 .   ? 151.54014 -27.15752 4.83590   1.000 31.08564  ? 581 HOH A O   1 
HETATM 2420 O O   . HOH F 5 .   ? 128.72024 -27.75466 -9.49328  1.000 33.90863  ? 582 HOH A O   1 
HETATM 2421 O O   . HOH F 5 .   ? 144.98533 -15.30200 9.88958   1.000 31.31409  ? 583 HOH A O   1 
HETATM 2422 O O   . HOH F 5 .   ? 146.912   -39.713   -13.859   1.000 37.25885  ? 584 HOH A O   1 
HETATM 2423 O O   . HOH F 5 .   ? 129.24598 -21.20614 -7.02413  1.000 20.99712  ? 585 HOH A O   1 
HETATM 2424 O O   . HOH F 5 .   ? 146.87324 8.59897   0.64974   1.000 47.15319  ? 586 HOH A O   1 
HETATM 2425 O O   . HOH F 5 .   ? 147.73714 -25.76217 -18.75318 1.000 38.82531  ? 587 HOH A O   1 
HETATM 2426 O O   . HOH F 5 .   ? 135.33624 14.28670  4.95976   1.000 51.19632  ? 588 HOH A O   1 
HETATM 2427 O O   . HOH F 5 .   ? 123.96630 -12.63951 -4.42352  1.000 40.78891  ? 589 HOH A O   1 
HETATM 2428 O O   . HOH F 5 .   ? 128.15201 -2.39269  5.90228   1.000 52.73059  ? 590 HOH A O   1 
HETATM 2429 O O   . HOH F 5 .   ? 122.38252 7.60315   4.30071   1.000 47.45258  ? 591 HOH A O   1 
HETATM 2430 O O   . HOH F 5 .   ? 131.11760 -9.85890  3.56118   1.000 26.92521  ? 592 HOH A O   1 
HETATM 2431 O O   . HOH F 5 .   ? 133.71413 -17.15667 6.60869   1.000 23.42314  ? 593 HOH A O   1 
HETATM 2432 O O   . HOH F 5 .   ? 134.21192 -18.21564 -15.45938 1.000 40.22855  ? 594 HOH A O   1 
HETATM 2433 O O   . HOH F 5 .   ? 131.22490 8.52164   16.26370  1.000 46.84834  ? 595 HOH A O   1 
HETATM 2434 O O   . HOH F 5 .   ? 141.90310 -7.14926  -13.26642 1.000 32.88421  ? 596 HOH A O   1 
HETATM 2435 O O   . HOH F 5 .   ? 146.42545 -15.93776 7.29158   1.000 19.99803  ? 597 HOH A O   1 
HETATM 2436 O O   . HOH F 5 .   ? 128.88489 -15.78691 16.65556  1.000 43.66488  ? 598 HOH A O   1 
HETATM 2437 O O   . HOH F 5 .   ? 139.31655 -35.37243 -8.93324  1.000 41.61315  ? 599 HOH A O   1 
HETATM 2438 O O   . HOH F 5 .   ? 151.63026 -32.95438 -10.99233 1.000 48.62406  ? 600 HOH A O   1 
HETATM 2439 O O   . HOH F 5 .   ? 132.33523 -28.23920 5.21138   1.000 28.16441  ? 601 HOH A O   1 
HETATM 2440 O O   . HOH F 5 .   ? 152.585   -13.854   8.774     1.000 45.57540  ? 602 HOH A O   1 
HETATM 2441 O O   . HOH F 5 .   ? 131.97306 -7.06149  -4.52834  1.000 39.16730  ? 603 HOH A O   1 
HETATM 2442 O O   . HOH F 5 .   ? 160.40638 -23.22426 -4.09962  1.000 49.11403  ? 604 HOH A O   1 
HETATM 2443 O O   . HOH F 5 .   ? 123.17269 -26.81760 4.36037   1.000 31.74055  ? 605 HOH A O   1 
HETATM 2444 O O   . HOH F 5 .   ? 122.49933 -31.50040 -10.20735 1.000 47.02861  ? 606 HOH A O   1 
HETATM 2445 O O   . HOH F 5 .   ? 131.37851 0.05021   -8.63821  1.000 50.31678  ? 607 HOH A O   1 
HETATM 2446 O O   . HOH F 5 .   ? 122.35469 -29.44032 4.02391   1.000 36.14139  ? 608 HOH A O   1 
HETATM 2447 O O   . HOH F 5 .   ? 125.63606 -16.73675 16.99583  1.000 46.98864  ? 609 HOH A O   1 
HETATM 2448 O O   . HOH F 5 .   ? 134.832   3.917     -7.938    1.000 36.66861  ? 610 HOH A O   1 
HETATM 2449 O O   . HOH F 5 .   ? 124.89642 -17.25460 -11.26409 1.000 40.52366  ? 611 HOH A O   1 
HETATM 2450 O O   . HOH F 5 .   ? 153.45784 -23.25781 -0.96400  1.000 24.16522  ? 612 HOH A O   1 
HETATM 2451 O O   . HOH F 5 .   ? 141.90350 -36.21771 -8.78846  1.000 34.89404  ? 613 HOH A O   1 
HETATM 2452 O O   . HOH F 5 .   ? 150.98721 6.18313   2.35605   1.000 51.77719  ? 614 HOH A O   1 
HETATM 2453 O O   . HOH F 5 .   ? 132.17072 -17.22593 1.53016   1.000 21.40784  ? 615 HOH A O   1 
HETATM 2454 O O   . HOH F 5 .   ? 139.07032 -18.90698 -18.31905 1.000 32.93886  ? 616 HOH A O   1 
HETATM 2455 O O   . HOH F 5 .   ? 144.22807 -4.19461  -6.69022  1.000 28.71637  ? 617 HOH A O   1 
HETATM 2456 O O   . HOH F 5 .   ? 123.91436 -21.41304 16.69498  1.000 29.18283  ? 618 HOH A O   1 
HETATM 2457 O O   . HOH F 5 .   ? 119.54275 -16.17492 -11.36953 1.000 47.17010  ? 619 HOH A O   1 
HETATM 2458 O O   . HOH F 5 .   ? 135.78013 0.45583   -7.32491  1.000 49.12220  ? 620 HOH A O   1 
HETATM 2459 O O   . HOH F 5 .   ? 133.54698 6.24835   17.73878  1.000 52.99632  ? 621 HOH A O   1 
HETATM 2460 O O   . HOH F 5 .   ? 154.73938 -17.11496 -9.82111  1.000 35.31543  ? 622 HOH A O   1 
HETATM 2461 O O   . HOH F 5 .   ? 122.98251 -29.12945 -2.94650  1.000 47.72616  ? 623 HOH A O   1 
HETATM 2462 O O   . HOH F 5 .   ? 138.44727 -31.59902 -16.60263 1.000 32.01943  ? 624 HOH A O   1 
HETATM 2463 O O   . HOH F 5 .   ? 138.42389 -2.93384  15.97135  1.000 37.34385  ? 625 HOH A O   1 
HETATM 2464 O O   . HOH F 5 .   ? 133.65175 -32.95480 -11.74009 1.000 36.83490  ? 626 HOH A O   1 
HETATM 2465 O O   . HOH F 5 .   ? 157.45905 -15.55011 6.66509   1.000 29.02159  ? 627 HOH A O   1 
HETATM 2466 O O   A HOH F 5 .   ? 130.53108 -31.59288 -7.69249  0.520 27.89440  ? 628 HOH A O   1 
HETATM 2467 O O   B HOH F 5 .   ? 130.49625 -29.30413 -8.10234  0.480 21.99678  ? 628 HOH A O   1 
HETATM 2468 O O   . HOH F 5 .   ? 142.34017 15.56046  3.84288   1.000 53.26143  ? 629 HOH A O   1 
HETATM 2469 O O   . HOH F 5 .   ? 118.59926 -12.81319 1.19146   1.000 38.50900  ? 630 HOH A O   1 
HETATM 2470 O O   . HOH F 5 .   ? 118.45891 -27.23340 3.90785   1.000 44.80767  ? 631 HOH A O   1 
HETATM 2471 O O   . HOH F 5 .   ? 126.99528 11.63043  6.57377   1.000 45.17874  ? 632 HOH A O   1 
HETATM 2472 O O   . HOH F 5 .   ? 125.17058 -8.42093  6.72479   1.000 46.29644  ? 633 HOH A O   1 
HETATM 2473 O O   . HOH F 5 .   ? 131.90598 -17.48846 4.35000   1.000 23.89166  ? 634 HOH A O   1 
HETATM 2474 O O   . HOH F 5 .   ? 146.26640 -18.45254 -17.42933 1.000 40.07966  ? 635 HOH A O   1 
HETATM 2475 O O   . HOH F 5 .   ? 144.78387 -6.20668  19.60196  1.000 54.13921  ? 636 HOH A O   1 
HETATM 2476 O O   . HOH F 5 .   ? 113.84784 -21.92493 4.48399   1.000 42.96857  ? 637 HOH A O   1 
HETATM 2477 O O   . HOH F 5 .   ? 137.20928 -35.19783 -4.63824  1.000 32.82920  ? 638 HOH A O   1 
HETATM 2478 O O   . HOH F 5 .   ? 129.29150 -33.50264 -6.12844  1.000 34.64756  ? 639 HOH A O   1 
HETATM 2479 O O   . HOH F 5 .   ? 154.29624 -25.27302 -8.33671  1.000 31.45176  ? 640 HOH A O   1 
HETATM 2480 O O   . HOH F 5 .   ? 134.42824 -12.37533 19.51490  1.000 51.77368  ? 641 HOH A O   1 
HETATM 2481 O O   . HOH F 5 .   ? 133.18372 -34.42658 -4.30985  1.000 44.93162  ? 642 HOH A O   1 
HETATM 2482 O O   . HOH F 5 .   ? 151.50926 -17.46398 -13.08768 1.000 45.85124  ? 643 HOH A O   1 
HETATM 2483 O O   . HOH F 5 .   ? 154.58793 -4.25630  3.55347   1.000 47.25371  ? 644 HOH A O   1 
HETATM 2484 O O   . HOH F 5 .   ? 124.42341 -11.75732 12.12824  1.000 32.35425  ? 645 HOH A O   1 
HETATM 2485 O O   . HOH F 5 .   ? 127.82434 -13.38241 -8.99578  1.000 22.70027  ? 646 HOH A O   1 
HETATM 2486 O O   . HOH F 5 .   ? 147.69022 -8.48949  11.67939  1.000 47.02300  ? 647 HOH A O   1 
HETATM 2487 O O   . HOH F 5 .   ? 122.29534 -14.62916 -4.67425  1.000 28.37789  ? 648 HOH A O   1 
HETATM 2488 O O   . HOH F 5 .   ? 151.70167 -25.42800 -11.29235 1.000 32.29800  ? 649 HOH A O   1 
HETATM 2489 O O   . HOH F 5 .   ? 152.29601 -18.03943 -10.68749 1.000 28.75665  ? 650 HOH A O   1 
HETATM 2490 O O   . HOH F 5 .   ? 141.78487 -34.50965 8.76615   1.000 40.31698  ? 651 HOH A O   1 
HETATM 2491 O O   . HOH F 5 .   ? 131.79757 -6.38584  18.29748  1.000 39.56963  ? 652 HOH A O   1 
HETATM 2492 O O   . HOH F 5 .   ? 154.16997 -27.43841 -5.83624  1.000 38.60309  ? 653 HOH A O   1 
HETATM 2493 O O   . HOH F 5 .   ? 126.85270 -3.64928  7.94092   1.000 35.93082  ? 654 HOH A O   1 
HETATM 2494 O O   . HOH F 5 .   ? 129.56533 -18.82303 4.59633   1.000 24.33629  ? 655 HOH A O   1 
HETATM 2495 O O   . HOH F 5 .   ? 151.71669 -34.44474 1.05402   1.000 49.72055  ? 656 HOH A O   1 
HETATM 2496 O O   . HOH F 5 .   ? 137.71757 -27.94501 11.00982  1.000 26.22566  ? 657 HOH A O   1 
HETATM 2497 O O   . HOH F 5 .   ? 149.37047 -10.39193 10.60045  1.000 47.91127  ? 658 HOH A O   1 
HETATM 2498 O O   . HOH F 5 .   ? 121.79856 -14.95803 11.07921  1.000 44.48982  ? 659 HOH A O   1 
HETATM 2499 O O   . HOH F 5 .   ? 145.89117 -3.56866  -9.73499  1.000 45.18175  ? 660 HOH A O   1 
HETATM 2500 O O   . HOH F 5 .   ? 133.71761 -35.86381 3.34796   1.000 39.03741  ? 661 HOH A O   1 
HETATM 2501 O O   . HOH F 5 .   ? 135.31218 -27.14403 9.79041   1.000 35.52022  ? 662 HOH A O   1 
HETATM 2502 O O   . HOH F 5 .   ? 128.10069 -26.66602 7.81973   1.000 25.78807  ? 663 HOH A O   1 
HETATM 2503 O O   . HOH F 5 .   ? 148.16170 -1.01249  10.97932  1.000 49.58860  ? 664 HOH A O   1 
HETATM 2504 O O   . HOH F 5 .   ? 139.594   10.598    -5.933    1.000 37.12382  ? 665 HOH A O   1 
HETATM 2505 O O   . HOH F 5 .   ? 129.72173 -15.60696 -1.73521  1.000 27.68342  ? 666 HOH A O   1 
HETATM 2506 O O   . HOH F 5 .   ? 149.32497 -13.37029 -18.28192 1.000 51.29748  ? 667 HOH A O   1 
HETATM 2507 O O   . HOH F 5 .   ? 120.75612 -26.38766 2.75015   1.000 38.75696  ? 668 HOH A O   1 
HETATM 2508 O O   . HOH F 5 .   ? 147.02466 4.21722   -2.08322  1.000 53.86484  ? 669 HOH A O   1 
HETATM 2509 O O   . HOH F 5 .   ? 130.23367 -4.53445  -5.16125  1.000 51.18519  ? 670 HOH A O   1 
HETATM 2510 O O   . HOH F 5 .   ? 155.99964 -12.91091 7.68285   1.000 53.94009  ? 671 HOH A O   1 
HETATM 2511 O O   . HOH F 5 .   ? 131.67904 -20.86181 -17.32405 1.000 49.37266  ? 672 HOH A O   1 
HETATM 2512 O O   . HOH F 5 .   ? 136.18888 7.64505   17.44144  1.000 52.70396  ? 673 HOH A O   1 
HETATM 2513 O O   . HOH F 5 .   ? 127.67198 4.09942   0.39463   1.000 38.63566  ? 674 HOH A O   1 
HETATM 2514 O O   . HOH F 5 .   ? 151.08437 -21.71783 -13.85680 1.000 49.55099  ? 675 HOH A O   1 
HETATM 2515 O O   . HOH F 5 .   ? 148.83361 -12.16207 7.86684   1.000 37.46701  ? 676 HOH A O   1 
HETATM 2516 O O   . HOH F 5 .   ? 133.63258 -16.59867 19.69058  1.000 47.94908  ? 677 HOH A O   1 
HETATM 2517 O O   . HOH F 5 .   ? 129.65435 -17.45959 0.38100   1.000 26.50942  ? 678 HOH A O   1 
HETATM 2518 O O   . HOH F 5 .   ? 157.249   -10.252   11.464    1.000 46.26138  ? 679 HOH A O   1 
HETATM 2519 O O   . HOH F 5 .   ? 146.71752 -2.29514  -7.17780  1.000 54.56597  ? 680 HOH A O   1 
HETATM 2520 O O   . HOH F 5 .   ? 142.95313 -12.94225 -17.50280 1.000 46.55077  ? 681 HOH A O   1 
HETATM 2521 O O   . HOH F 5 .   ? 134.02079 -7.22560  19.87479  1.000 45.05517  ? 682 HOH A O   1 
HETATM 2522 O O   . HOH F 5 .   ? 143.93004 -17.72415 -17.71322 1.000 52.51245  ? 683 HOH A O   1 
HETATM 2523 O O   . HOH F 5 .   ? 123.44694 -10.79717 9.78649   1.000 52.25743  ? 684 HOH A O   1 
HETATM 2524 O O   . HOH F 5 .   ? 126.49369 -2.66323  4.14874   1.000 60.80246  ? 685 HOH A O   1 
HETATM 2525 O O   . HOH F 5 .   ? 126.02843 -35.46481 -4.32425  1.000 41.00227  ? 686 HOH A O   1 
HETATM 2526 O O   . HOH F 5 .   ? 130.41665 -5.75917  0.81843   1.000 46.06480  ? 687 HOH A O   1 
HETATM 2527 O O   . HOH F 5 .   ? 130.37686 -35.02155 -4.45873  1.000 47.13005  ? 688 HOH A O   1 
HETATM 2528 O O   . HOH F 5 .   ? 134.51330 -32.40854 -17.29952 1.000 44.29759  ? 689 HOH A O   1 
HETATM 2529 O O   . HOH F 5 .   ? 133.73924 -9.58910  21.05188  1.000 56.09568  ? 690 HOH A O   1 
HETATM 2530 O O   . HOH F 5 .   ? 132.47759 -27.56031 7.63092   1.000 38.92352  ? 691 HOH A O   1 
HETATM 2531 O O   . HOH F 5 .   ? 146.56227 1.49515   -1.54065  1.000 43.82521  ? 692 HOH A O   1 
HETATM 2532 O O   . HOH F 5 .   ? 127.96529 -17.95152 2.51732   1.000 25.95336  ? 693 HOH A O   1 
HETATM 2533 O O   . HOH F 5 .   ? 121.73855 -29.82195 -1.01994  1.000 49.24682  ? 694 HOH A O   1 
HETATM 2534 O O   . HOH F 5 .   ? 137.56362 -0.08935  16.97391  1.000 49.08341  ? 695 HOH A O   1 
HETATM 2535 O O   . HOH F 5 .   ? 139.52358 -6.94693  -15.28929 1.000 50.27377  ? 696 HOH A O   1 
HETATM 2536 O O   . HOH F 5 .   ? 142.80424 -36.42355 2.12148   1.000 46.84692  ? 697 HOH A O   1 
HETATM 2537 O O   . HOH F 5 .   ? 113.97048 -26.70857 1.12941   1.000 50.53749  ? 698 HOH A O   1 
HETATM 2538 O O   . HOH F 5 .   ? 148.674   -17.289   7.941     1.000 31.94679  ? 699 HOH A O   1 
HETATM 2539 O O   . HOH F 5 .   ? 141.89181 -35.94286 6.60731   1.000 42.68783  ? 700 HOH A O   1 
HETATM 2540 O O   . HOH F 5 .   ? 120.85582 -28.90728 1.49877   1.000 50.13646  ? 701 HOH A O   1 
HETATM 2541 O O   . HOH G 5 .   ? 126.50935 -11.60337 -7.12723  1.000 30.61411  ? 101 HOH B O   1 
HETATM 2542 O O   . HOH G 5 .   ? 139.34172 -4.92214  -12.26167 1.000 43.75526  ? 102 HOH B O   1 
HETATM 2543 O O   . HOH G 5 .   ? 135.95410 -13.92209 -11.86142 1.000 26.43838  ? 103 HOH B O   1 
HETATM 2544 O O   . HOH G 5 .   ? 135.14161 -6.67175  -14.39519 1.000 33.30888  ? 104 HOH B O   1 
HETATM 2545 O O   . HOH G 5 .   ? 138.47709 -10.42888 -19.86136 1.000 51.89959  ? 105 HOH B O   1 
HETATM 2546 O O   . HOH G 5 .   ? 126.84218 -13.15288 -11.71800 1.000 34.42861  ? 106 HOH B O   1 
# 
loop_
_atom_site_anisotrop.id 
_atom_site_anisotrop.type_symbol 
_atom_site_anisotrop.pdbx_label_atom_id 
_atom_site_anisotrop.pdbx_label_alt_id 
_atom_site_anisotrop.pdbx_label_comp_id 
_atom_site_anisotrop.pdbx_label_asym_id 
_atom_site_anisotrop.pdbx_label_seq_id 
_atom_site_anisotrop.pdbx_PDB_ins_code 
_atom_site_anisotrop.U[1][1] 
_atom_site_anisotrop.U[2][2] 
_atom_site_anisotrop.U[3][3] 
_atom_site_anisotrop.U[1][2] 
_atom_site_anisotrop.U[1][3] 
_atom_site_anisotrop.U[2][3] 
_atom_site_anisotrop.pdbx_auth_seq_id 
_atom_site_anisotrop.pdbx_auth_comp_id 
_atom_site_anisotrop.pdbx_auth_asym_id 
_atom_site_anisotrop.pdbx_auth_atom_id 
1    N N   . PRO A 34  ? 1.05906 0.66919 0.94724 0.01571  0.03187  -0.08991 33  PRO A N   
2    C CA  . PRO A 34  ? 1.18133 0.78689 1.06662 0.02273  0.03345  -0.07819 33  PRO A CA  
3    C C   . PRO A 34  ? 1.14273 0.75826 1.03442 0.01018  0.03275  -0.07150 33  PRO A C   
4    O O   . PRO A 34  ? 1.10478 0.70995 0.99618 -0.00420 0.03277  -0.07420 33  PRO A O   
5    C CB  . PRO A 34  ? 1.20245 0.76884 1.07271 0.02698  0.03670  -0.07804 33  PRO A CB  
6    C CG  . PRO A 34  ? 1.26642 0.82518 1.13726 0.01406  0.03521  -0.08752 33  PRO A CG  
7    C CD  . PRO A 34  ? 1.21832 0.80183 1.09805 0.01246  0.03260  -0.09598 33  PRO A CD  
8    N N   . LEU A 35  ? 1.07896 0.71499 0.97590 0.01568  0.03223  -0.06266 34  LEU A N   
9    C CA  . LEU A 35  ? 1.04456 0.69371 0.94780 0.00473  0.03161  -0.05635 34  LEU A CA  
10   C C   . LEU A 35  ? 1.02207 0.64562 0.91869 -0.00244 0.03360  -0.05097 34  LEU A C   
11   O O   . LEU A 35  ? 0.87946 0.50641 0.78017 -0.01619 0.03335  -0.04975 34  LEU A O   
12   C CB  . LEU A 35  ? 0.99432 0.66816 0.90217 0.01299  0.03084  -0.04796 34  LEU A CB  
13   C CG  . LEU A 35  ? 0.91646 0.59621 0.82612 0.00701  0.03118  -0.03788 34  LEU A CG  
14   C CD1 . LEU A 35  ? 0.83472 0.53070 0.75211 -0.00779 0.03023  -0.04017 34  LEU A CD1 
15   C CD2 . LEU A 35  ? 0.88954 0.58785 0.80020 0.01831  0.03065  -0.02950 34  LEU A CD2 
16   N N   . GLU A 36  ? 1.06384 0.66136 0.94967 0.00686  0.03592  -0.04754 35  GLU A N   
17   C CA  . GLU A 36  ? 1.10517 0.67865 0.98380 0.00151  0.03819  -0.04083 35  GLU A CA  
18   C C   . GLU A 36  ? 1.08389 0.63862 0.95982 -0.01497 0.03866  -0.04714 35  GLU A C   
19   O O   . GLU A 36  ? 1.06969 0.61364 0.94370 -0.02458 0.03984  -0.04178 35  GLU A O   
20   C CB  . GLU A 36  ? 1.09842 0.64690 0.96457 0.01664  0.04113  -0.03587 35  GLU A CB  
21   C CG  . GLU A 36  ? 1.07148 0.63961 0.94009 0.03277  0.04080  -0.02743 35  GLU A CG  
22   C CD  . GLU A 36  ? 0.98060 0.56899 0.85382 0.04326  0.03913  -0.03317 35  GLU A CD  
23   N N   . SER A 37  ? 1.10241 0.65456 0.97829 -0.01900 0.03768  -0.05821 36  SER A N   
24   C CA  . SER A 37  ? 1.11832 0.66780 0.99740 -0.03382 0.03581  -0.06313 36  SER A CA  
25   C C   . SER A 37  ? 1.04233 0.61810 0.93367 -0.04713 0.03308  -0.06739 36  SER A C   
26   O O   . SER A 37  ? 1.00217 0.58068 0.89775 -0.06011 0.03141  -0.06846 36  SER A O   
27   C CB  . SER A 37  ? 1.13441 0.67190 1.00865 -0.02975 0.03506  -0.07116 36  SER A CB  
28   O OG  . SER A 37  ? 1.11574 0.66895 0.99435 -0.02462 0.03342  -0.07911 36  SER A OG  
29   N N   . GLN A 38  ? 0.99230 0.58778 0.88894 -0.04388 0.03283  -0.06960 37  GLN A N   
30   C CA  . GLN A 38  ? 0.85377 0.47504 0.76158 -0.05521 0.03075  -0.07313 37  GLN A CA  
31   C C   . GLN A 38  ? 0.78519 0.41686 0.69771 -0.06348 0.03175  -0.06500 37  GLN A C   
32   O O   . GLN A 38  ? 0.71543 0.36505 0.63626 -0.07444 0.03040  -0.06637 37  GLN A O   
33   C CB  . GLN A 38  ? 0.83256 0.47656 0.74610 -0.04794 0.02950  -0.07846 37  GLN A CB  
34   C CG  . GLN A 38  ? 0.92492 0.56303 0.83543 -0.04268 0.02842  -0.08835 37  GLN A CG  
35   C CD  . GLN A 38  ? 0.96119 0.62556 0.87892 -0.03730 0.02700  -0.09327 37  GLN A CD  
36   O OE1 . GLN A 38  ? 1.05291 0.71994 0.96878 -0.02409 0.02689  -0.09445 37  GLN A OE1 
37   N NE2 . GLN A 38  ? 0.85886 0.54456 0.78516 -0.04703 0.02592  -0.09548 37  GLN A NE2 
38   N N   . TYR A 39  ? 0.85802 0.48658 0.76804 -0.05672 0.03295  -0.05523 38  TYR A N   
39   C CA  . TYR A 39  ? 0.80538 0.44872 0.72078 -0.06256 0.03339  -0.04681 38  TYR A CA  
40   C C   . TYR A 39  ? 0.84969 0.47151 0.75799 -0.06333 0.03546  -0.03789 38  TYR A C   
41   O O   . TYR A 39  ? 0.87032 0.47391 0.77045 -0.05274 0.03652  -0.03495 38  TYR A O   
42   C CB  . TYR A 39  ? 0.71077 0.38050 0.63165 -0.05360 0.03247  -0.04309 38  TYR A CB  
43   C CG  . TYR A 39  ? 0.66955 0.36047 0.59694 -0.05338 0.03083  -0.05138 38  TYR A CG  
44   C CD1 . TYR A 39  ? 0.65452 0.36398 0.58898 -0.06359 0.03068  -0.05324 38  TYR A CD1 
45   C CD2 . TYR A 39  ? 0.67729 0.36930 0.60325 -0.04261 0.02977  -0.05723 38  TYR A CD2 
46   C CE1 . TYR A 39  ? 0.59521 0.32308 0.53481 -0.06304 0.02954  -0.06062 38  TYR A CE1 
47   C CE2 . TYR A 39  ? 0.66624 0.37712 0.59779 -0.04255 0.02842  -0.06483 38  TYR A CE2 
48   C CZ  . TYR A 39  ? 0.61145 0.33980 0.54962 -0.05281 0.02832  -0.06648 38  TYR A CZ  
49   O OH  . TYR A 39  ? 0.63523 0.38161 0.57817 -0.05227 0.02731  -0.07371 38  TYR A OH  
50   N N   . GLN A 40  ? 0.79989 0.42410 0.71100 -0.07544 0.03630  -0.03333 39  GLN A N   
51   C CA  . GLN A 40  ? 0.78578 0.39480 0.69161 -0.07695 0.03831  -0.02352 39  GLN A CA  
52   C C   . GLN A 40  ? 0.78300 0.41410 0.69371 -0.07289 0.03820  -0.01499 39  GLN A C   
53   O O   . GLN A 40  ? 0.76687 0.42136 0.68538 -0.07874 0.03757  -0.01568 39  GLN A O   
54   C CB  . GLN A 40  ? 0.79015 0.40098 0.70082 -0.09034 0.03736  -0.02268 39  GLN A CB  
55   C CG  . GLN A 40  ? 0.89185 0.48824 0.79810 -0.09163 0.03886  -0.01328 39  GLN A CG  
56   N N   . VAL A 41  ? 0.76782 0.39141 0.67307 -0.06268 0.03900  -0.00693 40  VAL A N   
57   C CA  . VAL A 41  ? 0.69208 0.33677 0.60051 -0.05718 0.03855  0.00077  40  VAL A CA  
58   C C   . VAL A 41  ? 0.72232 0.36305 0.62956 -0.06487 0.04028  0.01006  40  VAL A C   
59   O O   . VAL A 41  ? 0.69005 0.30669 0.59039 -0.06607 0.04204  0.01436  40  VAL A O   
60   C CB  . VAL A 41  ? 0.71606 0.35938 0.61985 -0.04076 0.03811  0.00447  40  VAL A CB  
61   C CG1 . VAL A 41  ? 0.68648 0.35329 0.59318 -0.03659 0.03736  0.01235  40  VAL A CG1 
62   C CG2 . VAL A 41  ? 0.70768 0.35471 0.61247 -0.03292 0.03666  -0.00474 40  VAL A CG2 
63   N N   . GLY A 42  ? 0.65418 0.31753 0.56710 -0.06990 0.04012  0.01326  41  GLY A N   
64   C CA  . GLY A 42  ? 0.68002 0.34280 0.59204 -0.07675 0.04184  0.02217  41  GLY A CA  
65   C C   . GLY A 42  ? 0.65862 0.33349 0.56872 -0.06878 0.04159  0.03092  41  GLY A C   
66   O O   . GLY A 42  ? 0.65054 0.32617 0.55777 -0.05664 0.04044  0.03227  41  GLY A O   
67   N N   . PRO A 43  ? 0.67756 0.36282 0.58883 -0.07554 0.04276  0.03723  42  PRO A N   
68   C CA  . PRO A 43  ? 0.64268 0.33811 0.55087 -0.06946 0.04259  0.04621  42  PRO A CA  
69   C C   . PRO A 43  ? 0.59075 0.31027 0.50129 -0.06330 0.04066  0.04362  42  PRO A C   
70   O O   . PRO A 43  ? 0.57445 0.30681 0.48965 -0.06645 0.04010  0.03591  42  PRO A O   
71   C CB  . PRO A 43  ? 0.65814 0.35755 0.56668 -0.08018 0.04471  0.05215  42  PRO A CB  
72   C CG  . PRO A 43  ? 0.76224 0.46568 0.67648 -0.09046 0.04549  0.04467  42  PRO A CG  
73   C CD  . PRO A 43  ? 0.70605 0.39300 0.62064 -0.08907 0.04457  0.03720  42  PRO A CD  
74   N N   . LEU A 44  ? 0.53365 0.25978 0.44047 -0.05470 0.03973  0.05060  43  LEU A N   
75   C CA  . LEU A 44  ? 0.51925 0.26980 0.42713 -0.05044 0.03802  0.04995  43  LEU A CA  
76   C C   . LEU A 44  ? 0.58995 0.35608 0.49896 -0.06070 0.03926  0.05009  43  LEU A C   
77   O O   . LEU A 44  ? 0.59840 0.36113 0.50494 -0.06709 0.04108  0.05660  43  LEU A O   
78   C CB  . LEU A 44  ? 0.56158 0.31679 0.46476 -0.04073 0.03690  0.05895  43  LEU A CB  
79   C CG  . LEU A 44  ? 0.54242 0.32344 0.44577 -0.03590 0.03480  0.05922  43  LEU A CG  
80   C CD1 . LEU A 44  ? 0.53033 0.31586 0.43677 -0.02740 0.03304  0.05162  43  LEU A CD1 
81   C CD2 . LEU A 44  ? 0.57117 0.35864 0.46954 -0.02955 0.03400  0.07014  43  LEU A CD2 
82   N N   . LEU A 45  ? 0.52926 0.31159 0.44119 -0.06197 0.03866  0.04300  44  LEU A N   
83   C CA  . LEU A 45  ? 0.50760 0.30406 0.41882 -0.07049 0.04042  0.04285  44  LEU A CA  
84   C C   . LEU A 45  ? 0.52643 0.34057 0.43274 -0.06822 0.03964  0.04746  44  LEU A C   
85   O O   . LEU A 45  ? 0.54419 0.36480 0.44633 -0.07492 0.04158  0.05157  44  LEU A O   
86   C CB  . LEU A 45  ? 0.52133 0.32467 0.43710 -0.07393 0.04088  0.03282  44  LEU A CB  
87   C CG  . LEU A 45  ? 0.54518 0.33486 0.46577 -0.07899 0.04184  0.02776  44  LEU A CG  
88   C CD1 . LEU A 45  ? 0.53640 0.33621 0.46117 -0.08098 0.04198  0.01824  44  LEU A CD1 
89   C CD2 . LEU A 45  ? 0.55934 0.34263 0.47906 -0.08814 0.04463  0.03324  44  LEU A CD2 
90   N N   . GLY A 46  ? 0.54153 0.36388 0.44766 -0.05920 0.03698  0.04699  45  GLY A N   
91   C CA  . GLY A 46  ? 0.50855 0.34915 0.40986 -0.05755 0.03583  0.05163  45  GLY A CA  
92   C C   . GLY A 46  ? 0.50191 0.35115 0.40478 -0.04657 0.03281  0.05040  45  GLY A C   
93   O O   . GLY A 46  ? 0.44807 0.29002 0.35546 -0.04067 0.03195  0.04447  45  GLY A O   
94   N N   . SER A 47  ? 0.44239 0.30793 0.34105 -0.04396 0.03126  0.05631  46  SER A N   
95   C CA  . SER A 47  ? 0.48060 0.35972 0.38062 -0.03388 0.02845  0.05585  46  SER A CA  
96   C C   . SER A 47  ? 0.50266 0.40581 0.39768 -0.03716 0.02728  0.05925  46  SER A C   
97   O O   . SER A 47  ? 0.50021 0.40629 0.38947 -0.04446 0.02829  0.06494  46  SER A O   
98   C CB  . SER A 47  ? 0.52336 0.39307 0.42365 -0.02222 0.02725  0.06250  46  SER A CB  
99   O OG  . SER A 47  ? 0.54537 0.41982 0.44057 -0.02252 0.02697  0.07301  46  SER A OG  
100  N N   . GLY A 48  ? 0.47917 0.39934 0.37585 -0.03199 0.02520  0.05573  47  GLY A N   
101  C CA  . GLY A 48  ? 0.52381 0.46832 0.41543 -0.03558 0.02383  0.05834  47  GLY A CA  
102  C C   . GLY A 48  ? 0.57725 0.53812 0.47231 -0.02975 0.02185  0.05272  47  GLY A C   
103  O O   . GLY A 48  ? 0.51155 0.46718 0.41245 -0.01908 0.02083  0.05030  47  GLY A O   
104  N N   . GLY A 49  ? 0.53013 0.50986 0.42060 -0.03716 0.02165  0.05044  48  GLY A N   
105  C CA  . GLY A 49  ? 0.50487 0.50145 0.39813 -0.03309 0.02001  0.04486  48  GLY A CA  
106  C C   . GLY A 49  ? 0.51928 0.50384 0.41887 -0.02990 0.02111  0.03494  48  GLY A C   
107  O O   . GLY A 49  ? 0.55473 0.54936 0.45846 -0.02279 0.01958  0.03078  48  GLY A O   
108  N N   . PHE A 50  ? 0.45199 0.41623 0.35238 -0.03505 0.02372  0.03124  49  PHE A N   
109  C CA  . PHE A 50  ? 0.49563 0.44814 0.40164 -0.03337 0.02480  0.02190  49  PHE A CA  
110  C C   . PHE A 50  ? 0.56556 0.50194 0.47769 -0.02283 0.02386  0.02172  49  PHE A C   
111  O O   . PHE A 50  ? 0.53075 0.45639 0.44727 -0.02137 0.02452  0.01397  49  PHE A O   
112  C CB  . PHE A 50  ? 0.49142 0.43130 0.39525 -0.04395 0.02814  0.01859  49  PHE A CB  
113  C CG  . PHE A 50  ? 0.52067 0.44749 0.42192 -0.04791 0.02941  0.02592  49  PHE A CG  
114  C CD1 . PHE A 50  ? 0.50103 0.40845 0.40688 -0.04398 0.02953  0.02706  49  PHE A CD1 
115  C CD2 . PHE A 50  ? 0.50443 0.43792 0.39775 -0.05583 0.03061  0.03176  49  PHE A CD2 
116  C CE1 . PHE A 50  ? 0.51617 0.41178 0.41946 -0.04780 0.03082  0.03411  49  PHE A CE1 
117  C CE2 . PHE A 50  ? 0.56077 0.48262 0.45156 -0.05926 0.03188  0.03873  49  PHE A CE2 
118  C CZ  . PHE A 50  ? 0.56441 0.46770 0.46058 -0.05516 0.03197  0.04002  49  PHE A CZ  
119  N N   . GLY A 51  ? 0.45817 0.39163 0.36970 -0.01568 0.02260  0.03006  50  GLY A N   
120  C CA  . GLY A 51  ? 0.46787 0.38207 0.38273 -0.00605 0.02251  0.03049  50  GLY A CA  
121  C C   . GLY A 51  ? 0.50251 0.39531 0.41554 -0.01045 0.02427  0.03513  50  GLY A C   
122  O O   . GLY A 51  ? 0.48164 0.37813 0.39059 -0.01765 0.02492  0.04122  50  GLY A O   
123  N N   . SER A 52  ? 0.42505 0.29513 0.34031 -0.00687 0.02520  0.03228  51  SER A N   
124  C CA  . SER A 52  ? 0.44968 0.29830 0.36329 -0.01216 0.02707  0.03586  51  SER A CA  
125  C C   . SER A 52  ? 0.46180 0.29630 0.37880 -0.01916 0.02857  0.02691  51  SER A C   
126  O O   . SER A 52  ? 0.44871 0.27816 0.36867 -0.01440 0.02805  0.01945  51  SER A O   
127  C CB  . SER A 52  ? 0.46056 0.29272 0.37183 -0.00173 0.02710  0.04233  51  SER A CB  
128  O OG  . SER A 52  ? 0.47078 0.31768 0.37901 0.00503  0.02575  0.05165  51  SER A OG  
129  N N   . VAL A 53  ? 0.41775 0.24668 0.33415 -0.03029 0.03047  0.02781  52  VAL A N   
130  C CA  . VAL A 53  ? 0.42059 0.24107 0.34049 -0.03813 0.03192  0.01993  52  VAL A CA  
131  C C   . VAL A 53  ? 0.42787 0.22682 0.34709 -0.04320 0.03360  0.02323  52  VAL A C   
132  O O   . VAL A 53  ? 0.47424 0.27143 0.39030 -0.04742 0.03475  0.03110  52  VAL A O   
133  C CB  . VAL A 53  ? 0.45834 0.29448 0.37811 -0.04728 0.03326  0.01718  52  VAL A CB  
134  C CG1 . VAL A 53  ? 0.42529 0.25429 0.34905 -0.05428 0.03485  0.00964  52  VAL A CG1 
135  C CG2 . VAL A 53  ? 0.43514 0.29170 0.35444 -0.04318 0.03180  0.01400  52  VAL A CG2 
136  N N   . TYR A 54  ? 0.42164 0.20440 0.34330 -0.04336 0.03379  0.01715  53  TYR A N   
137  C CA  . TYR A 54  ? 0.48761 0.24883 0.40839 -0.04909 0.03536  0.01909  53  TYR A CA  
138  C C   . TYR A 54  ? 0.52973 0.29059 0.45484 -0.05963 0.03650  0.01212  53  TYR A C   
139  O O   . TYR A 54  ? 0.51110 0.28115 0.43980 -0.05950 0.03574  0.00384  53  TYR A O   
140  C CB  . TYR A 54  ? 0.50694 0.24635 0.42505 -0.04133 0.03496  0.01809  53  TYR A CB  
141  C CG  . TYR A 54  ? 0.53176 0.26899 0.44508 -0.02959 0.03435  0.02584  53  TYR A CG  
142  C CD1 . TYR A 54  ? 0.48835 0.24009 0.40211 -0.01876 0.03254  0.02466  53  TYR A CD1 
143  C CD2 . TYR A 54  ? 0.52226 0.24395 0.43055 -0.02904 0.03572  0.03472  53  TYR A CD2 
144  C CE1 . TYR A 54  ? 0.46877 0.22103 0.37846 -0.00736 0.03204  0.03236  53  TYR A CE1 
145  C CE2 . TYR A 54  ? 0.58218 0.30281 0.48584 -0.01735 0.03534  0.04243  53  TYR A CE2 
146  C CZ  . TYR A 54  ? 0.54398 0.28076 0.44856 -0.00635 0.03346  0.04134  53  TYR A CZ  
147  O OH  . TYR A 54  ? 0.50192 0.24043 0.40227 0.00589  0.03311  0.04952  53  TYR A OH  
148  N N   . SER A 55  ? 0.54565 0.29650 0.47039 -0.06855 0.03838  0.01586  54  SER A N   
149  C CA  . SER A 55  ? 0.51023 0.25781 0.43904 -0.07818 0.03942  0.00997  54  SER A CA  
150  C C   . SER A 55  ? 0.58347 0.31259 0.51220 -0.07648 0.03841  0.00371  54  SER A C   
151  O O   . SER A 55  ? 0.62295 0.33469 0.54693 -0.07023 0.03810  0.00653  54  SER A O   
152  C CB  . SER A 55  ? 0.59544 0.33792 0.52371 -0.08813 0.04183  0.01645  54  SER A CB  
153  O OG  . SER A 55  ? 0.65888 0.40219 0.59167 -0.09758 0.04284  0.01124  54  SER A OG  
154  N N   . GLY A 56  ? 0.56526 0.29783 0.49837 -0.08183 0.03814  -0.00484 55  GLY A N   
155  C CA  . GLY A 56  ? 0.62331 0.33911 0.55550 -0.08115 0.03714  -0.01187 55  GLY A CA  
156  C C   . GLY A 56  ? 0.61434 0.33299 0.55123 -0.09207 0.03740  -0.01856 55  GLY A C   
157  O O   . GLY A 56  ? 0.60663 0.34234 0.54808 -0.09852 0.03845  -0.01811 55  GLY A O   
158  N N   . ILE A 57  ? 0.60367 0.30506 0.53856 -0.09394 0.03666  -0.02463 56  ILE A N   
159  C CA  . ILE A 57  ? 0.66132 0.36492 0.60016 -0.10425 0.03639  -0.03185 56  ILE A CA  
160  C C   . ILE A 57  ? 0.67760 0.37103 0.61414 -0.09967 0.03460  -0.04132 56  ILE A C   
161  O O   . ILE A 57  ? 0.79796 0.46938 0.72749 -0.09427 0.03450  -0.04123 56  ILE A O   
162  C CB  . ILE A 57  ? 0.69751 0.39712 0.63861 -0.11292 0.03591  -0.02712 56  ILE A CB  
163  C CG1 . ILE A 57  ? 0.67207 0.38992 0.61822 -0.11865 0.03745  -0.02010 56  ILE A CG1 
164  C CG2 . ILE A 57  ? 0.76594 0.46704 0.71087 -0.11875 0.03343  -0.03437 56  ILE A CG2 
165  N N   . ARG A 58  ? 0.67329 0.38332 0.61527 -0.10070 0.03329  -0.04912 57  ARG A N   
166  C CA  . ARG A 58  ? 0.68411 0.38810 0.62489 -0.09668 0.03110  -0.05824 57  ARG A CA  
167  C C   . ARG A 58  ? 0.75900 0.45488 0.70047 -0.10406 0.02896  -0.05979 57  ARG A C   
168  O O   . ARG A 58  ? 0.80503 0.51522 0.75285 -0.11335 0.02811  -0.05946 57  ARG A O   
169  C CB  . ARG A 58  ? 0.66539 0.39132 0.61201 -0.09581 0.03027  -0.06544 57  ARG A CB  
170  C CG  . ARG A 58  ? 0.73093 0.45287 0.67649 -0.09090 0.02780  -0.07473 57  ARG A CG  
171  C CD  . ARG A 58  ? 0.72902 0.47200 0.67923 -0.08724 0.02744  -0.08092 57  ARG A CD  
172  N NE  . ARG A 58  ? 0.75878 0.52386 0.71647 -0.09529 0.02712  -0.08095 57  ARG A NE  
173  C CZ  . ARG A 58  ? 0.73853 0.52410 0.70045 -0.09328 0.02740  -0.08471 57  ARG A CZ  
174  N NH1 . ARG A 58  ? 0.66151 0.45016 0.62180 -0.08419 0.02759  -0.08894 57  ARG A NH1 
175  N NH2 . ARG A 58  ? 0.77348 0.57717 0.74102 -0.10010 0.02781  -0.08390 57  ARG A NH2 
176  N N   . VAL A 59  ? 0.74684 0.41949 0.68101 -0.09984 0.02848  -0.06128 58  VAL A N   
177  C CA  . VAL A 59  ? 0.84082 0.50292 0.77396 -0.10761 0.02697  -0.06223 58  VAL A CA  
178  C C   . VAL A 59  ? 0.87992 0.55506 0.81809 -0.11329 0.02412  -0.07048 58  VAL A C   
179  O O   . VAL A 59  ? 0.98353 0.65816 0.92324 -0.12299 0.02289  -0.07081 58  VAL A O   
180  C CB  . VAL A 59  ? 0.86505 0.49785 0.78772 -0.10102 0.02773  -0.06200 58  VAL A CB  
181  C CG1 . VAL A 59  ? 0.87220 0.49261 0.78918 -0.09401 0.03067  -0.05320 58  VAL A CG1 
182  C CG2 . VAL A 59  ? 0.93833 0.56510 0.85704 -0.09194 0.02669  -0.07045 58  VAL A CG2 
183  N N   . SER A 60  ? 0.89930 0.58689 0.83988 -0.10761 0.02311  -0.07690 59  SER A N   
184  C CA  . SER A 60  ? 0.91011 0.61106 0.85511 -0.11217 0.02034  -0.08435 59  SER A CA  
185  C C   . SER A 60  ? 0.91500 0.63562 0.86773 -0.12365 0.02009  -0.08168 59  SER A C   
186  O O   . SER A 60  ? 0.98134 0.70346 0.93536 -0.13200 0.01824  -0.08437 59  SER A O   
187  C CB  . SER A 60  ? 0.83405 0.54810 0.78100 -0.10348 0.01974  -0.09032 59  SER A CB  
188  N N   . ASP A 61  ? 0.85397 0.58972 0.81133 -0.12422 0.02229  -0.07614 60  ASP A N   
189  C CA  . ASP A 61  ? 0.80991 0.56635 0.77450 -0.13339 0.02278  -0.07338 60  ASP A CA  
190  C C   . ASP A 61  ? 0.84818 0.60736 0.81416 -0.13607 0.02561  -0.06384 60  ASP A C   
191  O O   . ASP A 61  ? 0.83210 0.61086 0.80379 -0.14084 0.02703  -0.06086 60  ASP A O   
192  C CB  . ASP A 61  ? 0.84184 0.62169 0.81172 -0.13105 0.02282  -0.07796 60  ASP A CB  
193  C CG  . ASP A 61  ? 0.81883 0.60209 0.78747 -0.12135 0.02475  -0.07762 60  ASP A CG  
194  O OD1 . ASP A 61  ? 0.88221 0.64986 0.84586 -0.11649 0.02591  -0.07390 60  ASP A OD1 
195  O OD2 . ASP A 61  ? 0.86395 0.66544 0.83614 -0.11865 0.02532  -0.08095 60  ASP A OD2 
196  N N   . ASN A 62  ? 0.81757 0.55777 0.77799 -0.13259 0.02672  -0.05873 61  ASN A N   
197  C CA  . ASN A 62  ? 0.80366 0.54519 0.76447 -0.13405 0.02928  -0.04924 61  ASN A CA  
198  C C   . ASN A 62  ? 0.76406 0.52457 0.72799 -0.13084 0.03155  -0.04706 61  ASN A C   
199  O O   . ASN A 62  ? 0.80246 0.57243 0.76872 -0.13422 0.03364  -0.03999 61  ASN A O   
200  C CB  . ASN A 62  ? 0.81164 0.55708 0.77606 -0.14453 0.02930  -0.04455 61  ASN A CB  
201  C CG  . ASN A 62  ? 0.78741 0.51014 0.74675 -0.14765 0.02812  -0.04420 61  ASN A CG  
202  N N   . LEU A 63  ? 0.75879 0.52480 0.72220 -0.12410 0.03140  -0.05302 62  LEU A N   
203  C CA  . LEU A 63  ? 0.71016 0.49299 0.67529 -0.12124 0.03390  -0.05142 62  LEU A CA  
204  C C   . LEU A 63  ? 0.66441 0.43785 0.62424 -0.11684 0.03610  -0.04445 62  LEU A C   
205  O O   . LEU A 63  ? 0.68081 0.43634 0.63491 -0.11093 0.03562  -0.04503 62  LEU A O   
206  C CB  . LEU A 63  ? 0.64864 0.44018 0.61453 -0.11530 0.03314  -0.06000 62  LEU A CB  
207  C CG  . LEU A 63  ? 0.65176 0.45990 0.61829 -0.11245 0.03601  -0.05896 62  LEU A CG  
208  C CD1 . LEU A 63  ? 0.64090 0.46990 0.61290 -0.11809 0.03744  -0.05869 62  LEU A CD1 
209  C CD2 . LEU A 63  ? 0.66736 0.48031 0.63276 -0.10205 0.03457  -0.06484 62  LEU A CD2 
210  N N   . PRO A 64  ? 0.63891 0.42355 0.59961 -0.11916 0.03872  -0.03752 63  PRO A N   
211  C CA  . PRO A 64  ? 0.63948 0.41899 0.59515 -0.11414 0.04017  -0.03028 63  PRO A CA  
212  C C   . PRO A 64  ? 0.59389 0.38215 0.54816 -0.10326 0.03902  -0.03323 63  PRO A C   
213  O O   . PRO A 64  ? 0.58483 0.38954 0.54167 -0.10185 0.03935  -0.03784 63  PRO A O   
214  C CB  . PRO A 64  ? 0.63786 0.43077 0.59494 -0.11961 0.04324  -0.02335 63  PRO A CB  
215  C CG  . PRO A 64  ? 0.69810 0.50272 0.66194 -0.12600 0.04265  -0.02548 63  PRO A CG  
216  C CD  . PRO A 64  ? 0.66714 0.47169 0.63319 -0.12495 0.04028  -0.03538 63  PRO A CD  
217  N N   . VAL A 65  ? 0.55141 0.32918 0.50129 -0.09543 0.03786  -0.03018 64  VAL A N   
218  C CA  . VAL A 65  ? 0.53103 0.31798 0.47941 -0.08519 0.03668  -0.03186 64  VAL A CA  
219  C C   . VAL A 65  ? 0.53999 0.32581 0.48390 -0.08048 0.03708  -0.02285 64  VAL A C   
220  O O   . VAL A 65  ? 0.55051 0.32445 0.49201 -0.08351 0.03793  -0.01598 64  VAL A O   
221  C CB  . VAL A 65  ? 0.57180 0.34944 0.51961 -0.07792 0.03423  -0.03920 64  VAL A CB  
222  C CG1 . VAL A 65  ? 0.55073 0.33224 0.50265 -0.08240 0.03359  -0.04866 64  VAL A CG1 
223  C CG2 . VAL A 65  ? 0.56334 0.31671 0.50661 -0.07589 0.03371  -0.03634 64  VAL A CG2 
224  N N   . ALA A 66  ? 0.46080 0.25998 0.40335 -0.07342 0.03645  -0.02285 65  ALA A N   
225  C CA  . ALA A 66  ? 0.46256 0.26271 0.40079 -0.06727 0.03599  -0.01539 65  ALA A CA  
226  C C   . ALA A 66  ? 0.47504 0.27335 0.41251 -0.05622 0.03360  -0.01861 65  ALA A C   
227  O O   . ALA A 66  ? 0.47642 0.28219 0.41633 -0.05317 0.03263  -0.02637 65  ALA A O   
228  C CB  . ALA A 66  ? 0.44561 0.26428 0.38167 -0.06904 0.03741  -0.01184 65  ALA A CB  
229  N N   . ILE A 67  ? 0.45162 0.23997 0.38546 -0.04971 0.03290  -0.01242 66  ILE A N   
230  C CA  . ILE A 67  ? 0.47027 0.25367 0.40268 -0.03811 0.03116  -0.01443 66  ILE A CA  
231  C C   . ILE A 67  ? 0.48424 0.28179 0.41416 -0.03071 0.03032  -0.00751 66  ILE A C   
232  O O   . ILE A 67  ? 0.45227 0.24486 0.37873 -0.02956 0.03074  0.00135  66  ILE A O   
233  C CB  . ILE A 67  ? 0.49970 0.25676 0.42874 -0.03563 0.03149  -0.01328 66  ILE A CB  
234  C CG1 . ILE A 67  ? 0.48489 0.22920 0.41592 -0.04543 0.03222  -0.01981 66  ILE A CG1 
235  C CG2 . ILE A 67  ? 0.46581 0.21729 0.39244 -0.02263 0.03033  -0.01579 66  ILE A CG2 
236  C CD1 . ILE A 67  ? 0.56289 0.27863 0.48885 -0.04501 0.03292  -0.01932 66  ILE A CD1 
237  N N   . LYS A 68  ? 0.42482 0.24092 0.35630 -0.02624 0.02914  -0.01135 67  LYS A N   
238  C CA  . LYS A 68  ? 0.38985 0.22383 0.31919 -0.02109 0.02816  -0.00549 67  LYS A CA  
239  C C   . LYS A 68  ? 0.47770 0.31251 0.40656 -0.00762 0.02649  -0.00543 67  LYS A C   
240  O O   . LYS A 68  ? 0.44445 0.27983 0.37564 -0.00295 0.02581  -0.01320 67  LYS A O   
241  C CB  . LYS A 68  ? 0.37446 0.23014 0.30461 -0.02624 0.02836  -0.00904 67  LYS A CB  
242  C CG  . LYS A 68  ? 0.42043 0.29577 0.34776 -0.02186 0.02710  -0.00376 67  LYS A CG  
243  C CD  . LYS A 68  ? 0.52248 0.41754 0.44913 -0.02668 0.02750  -0.00829 67  LYS A CD  
244  C CE  . LYS A 68  ? 0.51420 0.41252 0.43673 -0.03777 0.02981  -0.00518 67  LYS A CE  
245  N NZ  . LYS A 68  ? 0.57053 0.48804 0.48923 -0.04160 0.03043  -0.00739 67  LYS A NZ  
246  N N   . HIS A 69  ? 0.43390 0.26969 0.35950 -0.00100 0.02599  0.00362  68  HIS A N   
247  C CA  . HIS A 69  ? 0.44597 0.28451 0.37046 0.01312  0.02480  0.00590  68  HIS A CA  
248  C C   . HIS A 69  ? 0.46578 0.33256 0.39027 0.01573  0.02321  0.01033  68  HIS A C   
249  O O   . HIS A 69  ? 0.42669 0.30263 0.34886 0.01019  0.02317  0.01736  68  HIS A O   
250  C CB  . HIS A 69  ? 0.47281 0.29192 0.39281 0.01997  0.02568  0.01387  68  HIS A CB  
251  C CG  . HIS A 69  ? 0.50147 0.29116 0.41982 0.01667  0.02742  0.01017  68  HIS A CG  
252  N ND1 . HIS A 69  ? 0.46273 0.23318 0.37820 0.02599  0.02814  0.00688  68  HIS A ND1 
253  C CD2 . HIS A 69  ? 0.50358 0.27992 0.42205 0.00462  0.02874  0.00930  68  HIS A CD2 
254  C CE1 . HIS A 69  ? 0.51000 0.25600 0.42347 0.01884  0.02968  0.00376  68  HIS A CE1 
255  N NE2 . HIS A 69  ? 0.50622 0.25639 0.42207 0.00585  0.02994  0.00536  68  HIS A NE2 
256  N N   . VAL A 70  ? 0.41106 0.29180 0.33760 0.02376  0.02195  0.00637  69  VAL A N   
257  C CA  . VAL A 70  ? 0.44327 0.35225 0.36973 0.02640  0.02028  0.01037  69  VAL A CA  
258  C C   . VAL A 70  ? 0.55275 0.46627 0.47918 0.04243  0.01933  0.01397  69  VAL A C   
259  O O   . VAL A 70  ? 0.46962 0.37344 0.39747 0.05044  0.01973  0.00799  69  VAL A O   
260  C CB  . VAL A 70  ? 0.46935 0.39576 0.39812 0.01959  0.01992  0.00237  69  VAL A CB  
261  C CG1 . VAL A 70  ? 0.55791 0.48107 0.48526 0.00486  0.02144  0.00052  69  VAL A CG1 
262  C CG2 . VAL A 70  ? 0.59616 0.51505 0.52840 0.02466  0.02009  -0.00749 69  VAL A CG2 
263  N N   . GLU A 71  ? 0.49410 0.42219 0.41842 0.04743  0.01827  0.02397  70  GLU A N   
264  C CA  . GLU A 71  ? 0.53638 0.47180 0.46053 0.06377  0.01763  0.02869  70  GLU A CA  
265  C C   . GLU A 71  ? 0.50374 0.46515 0.43143 0.06729  0.01610  0.02418  70  GLU A C   
266  O O   . GLU A 71  ? 0.51826 0.50165 0.44677 0.05777  0.01483  0.02319  70  GLU A O   
267  C CB  . GLU A 71  ? 0.56312 0.50866 0.48409 0.06819  0.01689  0.04146  70  GLU A CB  
268  C CG  . GLU A 71  ? 0.65326 0.57092 0.57001 0.07345  0.01884  0.04740  70  GLU A CG  
269  N N   . LYS A 72  ? 0.55406 0.51187 0.48295 0.08093  0.01653  0.02138  71  LYS A N   
270  C CA  . LYS A 72  ? 0.54048 0.52219 0.47295 0.08513  0.01531  0.01687  71  LYS A CA  
271  C C   . LYS A 72  ? 0.54713 0.56319 0.48004 0.08605  0.01316  0.02509  71  LYS A C   
272  O O   . LYS A 72  ? 0.60282 0.64229 0.53779 0.07959  0.01183  0.02152  71  LYS A O   
273  C CB  . LYS A 72  ? 0.52678 0.49782 0.45939 0.10135  0.01653  0.01389  71  LYS A CB  
274  C CG  . LYS A 72  ? 0.49243 0.43542 0.42483 0.09867  0.01818  0.00300  71  LYS A CG  
275  C CD  . LYS A 72  ? 0.55945 0.49336 0.49061 0.11489  0.01954  -0.00008 71  LYS A CD  
276  C CE  . LYS A 72  ? 0.54977 0.45557 0.47971 0.11163  0.02105  -0.01103 71  LYS A CE  
277  N NZ  . LYS A 72  ? 0.60570 0.49979 0.53252 0.12769  0.02281  -0.01400 71  LYS A NZ  
278  N N   . ASP A 73  ? 0.65312 0.67287 0.58355 0.09334  0.01284  0.03628  72  ASP A N   
279  C CA  . ASP A 73  ? 0.58889 0.64295 0.51954 0.09414  0.01053  0.04486  72  ASP A CA  
280  C C   . ASP A 73  ? 0.68732 0.75622 0.61650 0.07563  0.00915  0.04429  72  ASP A C   
281  O O   . ASP A 73  ? 0.68998 0.78992 0.61912 0.07271  0.00707  0.04824  72  ASP A O   
282  C CB  . ASP A 73  ? 0.72704 0.78004 0.65473 0.10518  0.01066  0.05738  72  ASP A CB  
283  C CG  . ASP A 73  ? 0.83710 0.87481 0.76414 0.12489  0.01273  0.05899  72  ASP A CG  
284  O OD1 . ASP A 73  ? 0.87881 0.91650 0.80841 0.13146  0.01337  0.05167  72  ASP A OD1 
285  O OD2 . ASP A 73  ? 1.02808 1.05300 0.95117 0.13410  0.01402  0.06769  72  ASP A OD2 
286  N N   . ARG A 74  ? 0.60126 0.64894 0.52850 0.06300  0.01046  0.03962  73  ARG A N   
287  C CA  . ARG A 74  ? 0.58845 0.64599 0.51241 0.04604  0.00998  0.03947  73  ARG A CA  
288  C C   . ARG A 74  ? 0.72797 0.78968 0.65272 0.03581  0.01055  0.02876  73  ARG A C   
289  O O   . ARG A 74  ? 0.82145 0.88897 0.74207 0.02168  0.01088  0.02764  73  ARG A O   
290  C CB  . ARG A 74  ? 0.58407 0.61754 0.50460 0.03849  0.01151  0.04213  73  ARG A CB  
291  C CG  . ARG A 74  ? 0.63759 0.67176 0.55537 0.04445  0.01087  0.05417  73  ARG A CG  
292  N N   . ILE A 75  ? 0.64023 0.59066 0.67501 0.04138  0.14740  0.02693  74  ILE A N   
293  C CA  . ILE A 75  ? 0.70400 0.65230 0.73221 0.03963  0.14170  0.02940  74  ILE A CA  
294  C C   . ILE A 75  ? 0.75233 0.70933 0.78863 0.03960  0.14412  0.04184  74  ILE A C   
295  O O   . ILE A 75  ? 0.73615 0.69535 0.76776 0.04346  0.15345  0.04819  74  ILE A O   
296  C CB  . ILE A 75  ? 0.65937 0.59808 0.66603 0.04279  0.14493  0.02506  74  ILE A CB  
297  C CG1 . ILE A 75  ? 0.63919 0.56930 0.63894 0.04195  0.14057  0.01236  74  ILE A CG1 
298  C CG2 . ILE A 75  ? 0.68921 0.62663 0.68891 0.04158  0.14066  0.02961  74  ILE A CG2 
299  C CD1 . ILE A 75  ? 0.67576 0.59666 0.65528 0.04598  0.14619  0.00706  74  ILE A CD1 
300  N N   . SER A 76  ? 0.80167 0.76366 0.85028 0.03518  0.13568  0.04527  75  SER A N   
301  C CA  . SER A 76  ? 0.75845 0.72907 0.81638 0.03453  0.13683  0.05695  75  SER A CA  
302  C C   . SER A 76  ? 0.79016 0.75790 0.83454 0.03600  0.13832  0.06192  75  SER A C   
303  O O   . SER A 76  ? 0.78547 0.75596 0.82566 0.03942  0.14696  0.06929  75  SER A O   
304  C CB  . SER A 76  ? 0.80838 0.78481 0.88351 0.02919  0.12687  0.05849  75  SER A CB  
305  N N   . ASP A 77  ? 0.72232 0.68452 0.75981 0.03343  0.12998  0.05796  76  ASP A N   
306  C CA  . ASP A 77  ? 0.71176 0.67107 0.73697 0.03424  0.13001  0.06249  76  ASP A CA  
307  C C   . ASP A 77  ? 0.64213 0.59090 0.64662 0.03732  0.13299  0.05526  76  ASP A C   
308  O O   . ASP A 77  ? 0.60448 0.54660 0.60433 0.03639  0.12857  0.04506  76  ASP A O   
309  C CB  . ASP A 77  ? 0.74995 0.71007 0.78078 0.02941  0.11872  0.06346  76  ASP A CB  
310  C CG  . ASP A 77  ? 0.77799 0.74848 0.82921 0.02621  0.11538  0.07076  76  ASP A CG  
311  N N   . TRP A 78  ? 0.64795 0.59524 0.64008 0.04093  0.14044  0.06057  77  TRP A N   
312  C CA  . TRP A 78  ? 0.67312 0.61071 0.64480 0.04407  0.14379  0.05501  77  TRP A CA  
313  C C   . TRP A 78  ? 0.69955 0.63369 0.66099 0.04308  0.13956  0.05808  77  TRP A C   
314  O O   . TRP A 78  ? 0.79518 0.73521 0.76387 0.04120  0.13728  0.06665  77  TRP A O   
315  C CB  . TRP A 78  ? 0.69193 0.62970 0.65576 0.04944  0.15645  0.05801  77  TRP A CB  
316  C CG  . TRP A 78  ? 0.71870 0.65797 0.68935 0.05093  0.16099  0.05355  77  TRP A CG  
317  C CD1 . TRP A 78  ? 0.71570 0.66373 0.70341 0.05030  0.16316  0.05802  77  TRP A CD1 
318  C CD2 . TRP A 78  ? 0.67237 0.60403 0.63285 0.05327  0.16383  0.04372  77  TRP A CD2 
319  N NE1 . TRP A 78  ? 0.73165 0.67794 0.72038 0.05209  0.16715  0.05159  77  TRP A NE1 
320  C CE2 . TRP A 78  ? 0.65956 0.59586 0.63175 0.05394  0.16768  0.04279  77  TRP A CE2 
321  C CE3 . TRP A 78  ? 0.70364 0.62498 0.64621 0.05488  0.16351  0.03566  77  TRP A CE3 
322  C CZ2 . TRP A 78  ? 0.70069 0.63161 0.66720 0.05612  0.17119  0.03412  77  TRP A CZ2 
323  C CZ3 . TRP A 78  ? 0.70978 0.62588 0.64685 0.05704  0.16701  0.02704  77  TRP A CZ3 
324  C CH2 . TRP A 78  ? 0.68148 0.60236 0.63046 0.05762  0.17081  0.02634  77  TRP A CH2 
325  N N   . GLY A 79  ? 0.70466 0.62899 0.64900 0.04433  0.13842  0.05087  78  GLY A N   
326  C CA  . GLY A 79  ? 0.69382 0.61358 0.62615 0.04381  0.13487  0.05282  78  GLY A CA  
327  C C   . GLY A 79  ? 0.80121 0.71213 0.71260 0.04801  0.14109  0.04876  78  GLY A C   
328  O O   . GLY A 79  ? 0.82345 0.73186 0.72998 0.05126  0.14800  0.04434  78  GLY A O   
329  N N   . GLU A 80  ? 0.77878 0.68497 0.67782 0.04789  0.13850  0.05034  79  GLU A N   
330  C CA  . GLU A 80  ? 0.96788 0.86556 0.84628 0.05171  0.14391  0.04720  79  GLU A CA  
331  C C   . GLU A 80  ? 1.04500 0.93397 0.91265 0.04957  0.13488  0.03999  79  GLU A C   
332  O O   . GLU A 80  ? 1.05656 0.94686 0.92914 0.04586  0.12632  0.04231  79  GLU A O   
333  C CB  . GLU A 80  ? 0.98458 0.88485 0.85592 0.05456  0.15174  0.05743  79  GLU A CB  
334  N N   . LEU A 81  ? 1.13046 1.01056 0.98371 0.05190  0.13675  0.03114  80  LEU A N   
335  C CA  . LEU A 81  ? 1.30119 1.17208 1.14132 0.05070  0.12965  0.02420  80  LEU A CA  
336  C C   . LEU A 81  ? 1.42630 1.29394 1.25139 0.05279  0.13294  0.02997  80  LEU A C   
337  O O   . LEU A 81  ? 1.37548 1.24753 1.19953 0.05549  0.14142  0.03847  80  LEU A O   
338  C CB  . LEU A 81  ? 1.31283 1.17567 1.14345 0.05253  0.13090  0.01269  80  LEU A CB  
339  N N   . PRO A 82  ? 1.48412 1.34416 1.29752 0.05151  0.12621  0.02569  81  PRO A N   
340  C CA  . PRO A 82  ? 1.48997 1.34563 1.28675 0.05395  0.13000  0.03008  81  PRO A CA  
341  C C   . PRO A 82  ? 1.48582 1.33825 1.26939 0.05932  0.14178  0.02982  81  PRO A C   
342  O O   . PRO A 82  ? 1.47716 1.33094 1.25360 0.06182  0.14853  0.03760  81  PRO A O   
343  C CB  . PRO A 82  ? 1.53471 1.38135 1.32085 0.05184  0.12055  0.02241  81  PRO A CB  
344  C CG  . PRO A 82  ? 1.51144 1.35706 1.30711 0.04901  0.11329  0.01292  81  PRO A CG  
345  C CD  . PRO A 82  ? 1.46223 1.31814 1.27817 0.04744  0.11436  0.01784  81  PRO A CD  
346  N N   . ASN A 83  ? 1.51724 1.36556 1.29757 0.06115  0.14455  0.02113  82  ASN A N   
347  C CA  . ASN A 83  ? 1.48127 1.32661 1.24969 0.06629  0.15579  0.02048  82  ASN A CA  
348  C C   . ASN A 83  ? 1.48526 1.33957 1.26311 0.06854  0.16529  0.02934  82  ASN A C   
349  O O   . ASN A 83  ? 1.43602 1.28877 1.20453 0.07295  0.17528  0.03027  82  ASN A O   
350  C CB  . ASN A 83  ? 1.35643 1.19561 1.12067 0.06738  0.15594  0.00891  82  ASN A CB  
351  N N   . GLY A 84  ? 1.45347 1.31706 1.24942 0.06568  0.16247  0.03582  83  GLY A N   
352  C CA  . GLY A 84  ? 1.37960 1.25208 1.18613 0.06753  0.17086  0.04380  83  GLY A CA  
353  C C   . GLY A 84  ? 1.32592 1.20108 1.14241 0.06831  0.17400  0.03911  83  GLY A C   
354  O O   . GLY A 84  ? 1.31823 1.20113 1.14490 0.06971  0.18065  0.04545  83  GLY A O   
355  N N   . THR A 85  ? 1.23665 1.10563 1.05049 0.06748  0.16949  0.02825  84  THR A N   
356  C CA  . THR A 85  ? 1.14906 1.02028 0.97258 0.06792  0.17180  0.02333  84  THR A CA  
357  C C   . THR A 85  ? 1.05200 0.93283 0.89733 0.06423  0.16720  0.02776  84  THR A C   
358  O O   . THR A 85  ? 1.01060 0.89280 0.86322 0.05996  0.15756  0.02803  84  THR A O   
359  C CB  . THR A 85  ? 0.98780 0.85028 0.80429 0.06717  0.16662  0.01069  84  THR A CB  
360  N N   . ARG A 86  ? 0.93672 0.82422 0.79240 0.06593  0.17418  0.03134  85  ARG A N   
361  C CA  . ARG A 86  ? 0.90530 0.80223 0.78194 0.06282  0.17088  0.03566  85  ARG A CA  
362  C C   . ARG A 86  ? 0.90688 0.80191 0.79154 0.06012  0.16422  0.02601  85  ARG A C   
363  O O   . ARG A 86  ? 0.81694 0.70852 0.69810 0.06236  0.16850  0.01937  85  ARG A O   
364  C CB  . ARG A 86  ? 0.91180 0.81634 0.79570 0.06590  0.18123  0.04319  85  ARG A CB  
365  C CG  . ARG A 86  ? 0.96356 0.87869 0.86891 0.06311  0.17904  0.04949  85  ARG A CG  
366  C CD  . ARG A 86  ? 0.97125 0.89363 0.88148 0.06654  0.18987  0.05817  85  ARG A CD  
367  N NE  . ARG A 86  ? 0.96773 0.90033 0.89852 0.06413  0.18836  0.06417  85  ARG A NE  
368  C CZ  . ARG A 86  ? 0.94368 0.88042 0.88571 0.06466  0.19140  0.06261  85  ARG A CZ  
369  N NH1 . ARG A 86  ? 0.93227 0.86400 0.86813 0.06697  0.19407  0.05486  85  ARG A NH1 
370  N NH2 . ARG A 86  ? 0.85846 0.80457 0.81902 0.06227  0.18956  0.06858  85  ARG A NH2 
371  N N   . VAL A 87  ? 0.76596 0.66304 0.66107 0.05530  0.15374  0.02510  86  VAL A N   
372  C CA  . VAL A 87  ? 0.70118 0.59625 0.60381 0.05227  0.14639  0.01580  86  VAL A CA  
373  C C   . VAL A 87  ? 0.65839 0.56266 0.58207 0.04815  0.14060  0.02041  86  VAL A C   
374  O O   . VAL A 87  ? 0.68664 0.59730 0.61700 0.04705  0.14012  0.02989  86  VAL A O   
375  C CB  . VAL A 87  ? 0.69240 0.57830 0.58384 0.05025  0.13776  0.00726  86  VAL A CB  
376  C CG1 . VAL A 87  ? 0.68897 0.56559 0.55946 0.05437  0.14352  0.00239  86  VAL A CG1 
377  C CG2 . VAL A 87  ? 0.62785 0.51545 0.52129 0.04697  0.13001  0.01256  86  VAL A CG2 
378  N N   . PRO A 88  ? 0.60571 0.51086 0.54019 0.04580  0.13621  0.01394  87  PRO A N   
379  C CA  . PRO A 88  ? 0.56365 0.47678 0.51770 0.04140  0.12928  0.01737  87  PRO A CA  
380  C C   . PRO A 88  ? 0.50396 0.41660 0.45832 0.03771  0.11974  0.01940  87  PRO A C   
381  O O   . PRO A 88  ? 0.51784 0.42251 0.45903 0.03742  0.11549  0.01402  87  PRO A O   
382  C CB  . PRO A 88  ? 0.52714 0.43818 0.48792 0.03951  0.12511  0.00741  87  PRO A CB  
383  C CG  . PRO A 88  ? 0.54507 0.44991 0.49309 0.04384  0.13324  0.00157  87  PRO A CG  
384  C CD  . PRO A 88  ? 0.55409 0.45303 0.48355 0.04694  0.13726  0.00320  87  PRO A CD  
385  N N   A MET A 89  ? 0.51318 0.43453 0.48281 0.03494  0.11652  0.02742  88  MET A N   
386  N N   B MET A 89  ? 0.51323 0.43448 0.48276 0.03488  0.11634  0.02734  88  MET A N   
387  C CA  A MET A 89  ? 0.51500 0.43695 0.48774 0.03097  0.10681  0.02967  88  MET A CA  
388  C CA  B MET A 89  ? 0.51509 0.43630 0.48629 0.03111  0.10680  0.02936  88  MET A CA  
389  C C   A MET A 89  ? 0.44285 0.35872 0.41490 0.02757  0.09659  0.01905  88  MET A C   
390  C C   B MET A 89  ? 0.44285 0.35867 0.41495 0.02748  0.09635  0.01898  88  MET A C   
391  O O   A MET A 89  ? 0.43316 0.34446 0.39816 0.02570  0.08964  0.01732  88  MET A O   
392  O O   B MET A 89  ? 0.43281 0.34448 0.39899 0.02534  0.08895  0.01736  88  MET A O   
393  C CB  A MET A 89  ? 0.51630 0.44903 0.50828 0.02823  0.10466  0.03864  88  MET A CB  
394  C CB  B MET A 89  ? 0.52050 0.45223 0.50918 0.02853  0.10480  0.03934  88  MET A CB  
395  C CG  A MET A 89  ? 0.46083 0.39508 0.45801 0.02390  0.09448  0.04147  88  MET A CG  
396  C CG  B MET A 89  ? 0.53731 0.47303 0.52221 0.03079  0.11119  0.05062  88  MET A CG  
397  S SD  A MET A 89  ? 0.56908 0.49897 0.54941 0.02551  0.09557  0.04703  88  MET A SD  
398  S SD  B MET A 89  ? 0.57432 0.50219 0.53973 0.03148  0.10886  0.05133  88  MET A SD  
399  C CE  A MET A 89  ? 0.57359 0.51133 0.55639 0.02926  0.10771  0.05940  88  MET A CE  
400  C CE  B MET A 89  ? 0.51391 0.44193 0.48812 0.02540  0.09415  0.04917  88  MET A CE  
401  N N   . GLU A 90  ? 0.41116 0.32680 0.39032 0.02678  0.09563  0.01177  89  GLU A N   
402  C CA  . GLU A 90  ? 0.39210 0.30236 0.37168 0.02346  0.08609  0.00140  89  GLU A CA  
403  C C   . GLU A 90  ? 0.38202 0.28149 0.34177 0.02499  0.08489  -0.00573 89  GLU A C   
404  O O   . GLU A 90  ? 0.38469 0.27976 0.34208 0.02195  0.07556  -0.01100 89  GLU A O   
405  C CB  . GLU A 90  ? 0.41574 0.32703 0.40429 0.02311  0.08714  -0.00524 89  GLU A CB  
406  C CG  . GLU A 90  ? 0.40095 0.30692 0.39051 0.01969  0.07771  -0.01621 89  GLU A CG  
407  C CD  . GLU A 90  ? 0.48747 0.39429 0.48564 0.01930  0.07887  -0.02288 89  GLU A CD  
408  O OE1 . GLU A 90  ? 0.43065 0.34191 0.43358 0.02185  0.08719  -0.01916 89  GLU A OE1 
409  O OE2 . GLU A 90  ? 0.40439 0.30730 0.40443 0.01640  0.07134  -0.03191 89  GLU A OE2 
410  N N   . VAL A 91  ? 0.39771 0.29284 0.34306 0.02971  0.09419  -0.00590 90  VAL A N   
411  C CA  . VAL A 91  ? 0.37643 0.26136 0.30223 0.03150  0.09378  -0.01210 90  VAL A CA  
412  C C   . VAL A 91  ? 0.45976 0.34353 0.37858 0.03064  0.08998  -0.00647 90  VAL A C   
413  O O   . VAL A 91  ? 0.42855 0.30527 0.33796 0.02923  0.08322  -0.01223 90  VAL A O   
414  C CB  . VAL A 91  ? 0.45304 0.33406 0.36575 0.03686  0.10514  -0.01329 90  VAL A CB  
415  C CG1 . VAL A 91  ? 0.50686 0.37774 0.39873 0.03896  0.10533  -0.01823 90  VAL A CG1 
416  C CG2 . VAL A 91  ? 0.45459 0.33506 0.37251 0.03745  0.10767  -0.02068 90  VAL A CG2 
417  N N   . VAL A 92  ? 0.40001 0.29055 0.32316 0.03147  0.09423  0.00478  91  VAL A N   
418  C CA  . VAL A 92  ? 0.43737 0.32739 0.35496 0.03044  0.09053  0.01076  91  VAL A CA  
419  C C   . VAL A 92  ? 0.39668 0.28681 0.32256 0.02525  0.07787  0.00791  91  VAL A C   
420  O O   . VAL A 92  ? 0.41018 0.29423 0.32599 0.02413  0.07191  0.00526  91  VAL A O   
421  C CB  . VAL A 92  ? 0.44015 0.33870 0.36418 0.03166  0.09674  0.02353  91  VAL A CB  
422  C CG1 . VAL A 92  ? 0.45614 0.35509 0.37741 0.02968  0.09136  0.02995  91  VAL A CG1 
423  C CG2 . VAL A 92  ? 0.55155 0.44897 0.46472 0.03702  0.10918  0.02638  91  VAL A CG2 
424  N N   . LEU A 93  ? 0.35258 0.24975 0.29711 0.02201  0.07359  0.00862  92  LEU A N   
425  C CA  . LEU A 93  ? 0.33602 0.23432 0.29024 0.01692  0.06161  0.00663  92  LEU A CA  
426  C C   . LEU A 93  ? 0.36228 0.25174 0.30887 0.01546  0.05456  -0.00560 92  LEU A C   
427  O O   . LEU A 93  ? 0.37677 0.26260 0.32005 0.01279  0.04584  -0.00786 92  LEU A O   
428  C CB  . LEU A 93  ? 0.32259 0.23030 0.29847 0.01401  0.05928  0.00953  92  LEU A CB  
429  C CG  . LEU A 93  ? 0.34973 0.26706 0.33548 0.01506  0.06568  0.02170  92  LEU A CG  
430  C CD1 . LEU A 93  ? 0.37418 0.30013 0.38125 0.01199  0.06262  0.02325  92  LEU A CD1 
431  C CD2 . LEU A 93  ? 0.35212 0.27107 0.33466 0.01429  0.06344  0.03042  92  LEU A CD2 
432  N N   . LEU A 94  ? 0.35945 0.24549 0.30369 0.01705  0.05801  -0.01369 93  LEU A N   
433  C CA  . LEU A 94  ? 0.37211 0.24971 0.30907 0.01576  0.05172  -0.02564 93  LEU A CA  
434  C C   . LEU A 94  ? 0.38885 0.25748 0.30601 0.01756  0.05117  -0.02811 93  LEU A C   
435  O O   . LEU A 94  ? 0.42962 0.29272 0.34255 0.01506  0.04237  -0.03450 93  LEU A O   
436  C CB  . LEU A 94  ? 0.36800 0.24340 0.30462 0.01768  0.05693  -0.03322 93  LEU A CB  
437  C CG  . LEU A 94  ? 0.37830 0.26006 0.33400 0.01469  0.05379  -0.03520 93  LEU A CG  
438  C CD1 . LEU A 94  ? 0.39758 0.27798 0.35218 0.01747  0.06141  -0.04043 93  LEU A CD1 
439  C CD2 . LEU A 94  ? 0.43640 0.31589 0.39808 0.00995  0.04179  -0.04266 93  LEU A CD2 
440  N N   . LYS A 95  ? 0.41564 0.28265 0.32046 0.02189  0.06047  -0.02322 94  LYS A N   
441  C CA  . LYS A 95  ? 0.41290 0.27148 0.29861 0.02370  0.06025  -0.02506 94  LYS A CA  
442  C C   . LYS A 95  ? 0.42168 0.28091 0.30853 0.02056  0.05177  -0.02062 94  LYS A C   
443  O O   . LYS A 95  ? 0.48567 0.33745 0.36160 0.01968  0.04571  -0.02595 94  LYS A O   
444  C CB  . LYS A 95  ? 0.47330 0.33103 0.34680 0.02882  0.07204  -0.01943 94  LYS A CB  
445  C CG  . LYS A 95  ? 0.50298 0.35600 0.36793 0.03256  0.07989  -0.02627 94  LYS A CG  
446  C CD  . LYS A 95  ? 0.64251 0.49415 0.49416 0.03764  0.09116  -0.02076 94  LYS A CD  
447  N N   . LYS A 96  ? 0.39619 0.26430 0.29646 0.01877  0.05102  -0.01096 95  LYS A N   
448  C CA  . LYS A 96  ? 0.41756 0.28671 0.31946 0.01578  0.04317  -0.00609 95  LYS A CA  
449  C C   . LYS A 96  ? 0.44885 0.31574 0.35728 0.01115  0.03077  -0.01361 95  LYS A C   
450  O O   . LYS A 96  ? 0.45038 0.31383 0.35359 0.00922  0.02352  -0.01356 95  LYS A O   
451  C CB  . LYS A 96  ? 0.44574 0.32525 0.36130 0.01490  0.04545  0.00591  95  LYS A CB  
452  C CG  . LYS A 96  ? 0.47635 0.35752 0.38334 0.01925  0.05664  0.01452  95  LYS A CG  
453  C CD  . LYS A 96  ? 0.51602 0.40804 0.43798 0.01864  0.06003  0.02580  95  LYS A CD  
454  C CE  . LYS A 96  ? 0.58855 0.48378 0.51519 0.01549  0.05308  0.03297  95  LYS A CE  
455  N NZ  . LYS A 96  ? 0.74755 0.63715 0.65689 0.01745  0.05482  0.03622  95  LYS A NZ  
456  N N   . VAL A 97  ? 0.40476 0.27350 0.32456 0.00927  0.02805  -0.02010 96  VAL A N   
457  C CA  . VAL A 97  ? 0.39990 0.26734 0.32758 0.00466  0.01626  -0.02695 96  VAL A CA  
458  C C   . VAL A 97  ? 0.41390 0.27205 0.33126 0.00495  0.01340  -0.03967 96  VAL A C   
459  O O   . VAL A 97  ? 0.46497 0.32094 0.38696 0.00130  0.00354  -0.04637 96  VAL A O   
460  C CB  . VAL A 97  ? 0.40632 0.28257 0.35559 0.00145  0.01324  -0.02556 96  VAL A CB  
461  C CG1 . VAL A 97  ? 0.36354 0.24928 0.32427 0.00063  0.01484  -0.01297 96  VAL A CG1 
462  C CG2 . VAL A 97  ? 0.39976 0.27684 0.35238 0.00344  0.02007  -0.03021 96  VAL A CG2 
463  N N   . SER A 98  ? 0.36527 0.31840 0.33106 0.02291  -0.02316 -0.03032 97  SER A N   
464  C CA  . SER A 98  ? 0.42622 0.36845 0.39140 0.01361  -0.02083 -0.03826 97  SER A CA  
465  C C   . SER A 98  ? 0.49840 0.44283 0.46616 0.01106  -0.02480 -0.04884 97  SER A C   
466  O O   . SER A 98  ? 0.53819 0.47245 0.50503 0.00367  -0.02357 -0.05559 97  SER A O   
467  C CB  . SER A 98  ? 0.43783 0.35813 0.39122 0.01485  -0.01541 -0.03549 97  SER A CB  
468  O OG  . SER A 98  ? 0.40100 0.31794 0.35289 0.01424  -0.01135 -0.02709 97  SER A OG  
469  N N   . SER A 99  ? 0.50590 0.46299 0.47690 0.01671  -0.02978 -0.05031 98  SER A N   
470  C CA  . SER A 99  ? 0.59136 0.55106 0.56490 0.01433  -0.03401 -0.06048 98  SER A CA  
471  C C   . SER A 99  ? 0.55306 0.52823 0.53971 0.00540  -0.03707 -0.06601 98  SER A C   
472  O O   . SER A 99  ? 0.57809 0.56872 0.57202 0.00623  -0.03902 -0.06206 98  SER A O   
473  C CB  . SER A 99  ? 0.61299 0.57896 0.58354 0.02460  -0.03787 -0.05975 98  SER A CB  
474  N N   . GLY A 100 ? 0.57062 0.54133 0.56016 -0.00305 -0.03768 -0.07492 99  GLY A N   
475  C CA  . GLY A 100 ? 0.56231 0.54739 0.56452 -0.01167 -0.04023 -0.08054 99  GLY A CA  
476  C C   . GLY A 100 ? 0.62103 0.60852 0.62807 -0.01814 -0.03594 -0.07624 99  GLY A C   
477  O O   . GLY A 100 ? 0.58172 0.55924 0.58230 -0.01645 -0.03114 -0.06905 99  GLY A O   
478  N N   . PHE A 101 ? 0.53781 0.53905 0.55627 -0.02537 -0.03773 -0.08075 100 PHE A N   
479  C CA  . PHE A 101 ? 0.50768 0.51305 0.53124 -0.03144 -0.03381 -0.07730 100 PHE A CA  
480  C C   . PHE A 101 ? 0.49419 0.51108 0.51902 -0.02559 -0.03481 -0.06980 100 PHE A C   
481  O O   . PHE A 101 ? 0.49117 0.51996 0.51874 -0.01999 -0.04005 -0.06991 100 PHE A O   
482  C CB  . PHE A 101 ? 0.57976 0.59603 0.61516 -0.04100 -0.03514 -0.08486 100 PHE A CB  
483  C CG  . PHE A 101 ? 0.61611 0.62228 0.65190 -0.04787 -0.03513 -0.09236 100 PHE A CG  
484  C CD1 . PHE A 101 ? 0.63840 0.62934 0.67035 -0.05400 -0.02983 -0.09108 100 PHE A CD1 
485  C CD2 . PHE A 101 ? 0.62482 0.63639 0.66478 -0.04843 -0.04085 -0.10061 100 PHE A CD2 
486  C CE1 . PHE A 101 ? 0.68156 0.66257 0.71396 -0.06078 -0.03058 -0.09778 100 PHE A CE1 
487  C CE2 . PHE A 101 ? 0.67744 0.67910 0.71766 -0.05501 -0.04164 -0.10754 100 PHE A CE2 
488  C CZ  . PHE A 101 ? 0.70980 0.69607 0.74634 -0.06131 -0.03667 -0.10606 100 PHE A CZ  
489  N N   . SER A 102 ? 0.39636 0.40938 0.41907 -0.02712 -0.03008 -0.06319 101 SER A N   
490  C CA  . SER A 102 ? 0.48525 0.50795 0.50880 -0.02231 -0.03134 -0.05597 101 SER A CA  
491  C C   . SER A 102 ? 0.43005 0.44688 0.45156 -0.02640 -0.02551 -0.05062 101 SER A C   
492  O O   . SER A 102 ? 0.45370 0.45919 0.47318 -0.03257 -0.02044 -0.05209 101 SER A O   
493  C CB  . SER A 102 ? 0.44863 0.46840 0.46501 -0.01199 -0.03341 -0.04916 101 SER A CB  
494  O OG  . SER A 102 ? 0.47417 0.47693 0.48080 -0.00993 -0.02814 -0.04330 101 SER A OG  
495  N N   . GLY A 103 ? 0.37261 0.39683 0.39431 -0.02286 -0.02659 -0.04422 102 GLY A N   
496  C CA  . GLY A 103 ? 0.28638 0.30481 0.30463 -0.02512 -0.02153 -0.03812 102 GLY A CA  
497  C C   . GLY A 103 ? 0.32639 0.33020 0.33413 -0.01970 -0.01850 -0.02955 102 GLY A C   
498  O O   . GLY A 103 ? 0.30521 0.30791 0.30951 -0.01743 -0.01726 -0.02214 102 GLY A O   
499  N N   A VAL A 104 ? 0.32773 0.31989 0.32991 -0.01733 -0.01743 -0.03050 103 VAL A N   
500  N N   B VAL A 104 ? 0.32766 0.32014 0.32980 -0.01696 -0.01762 -0.03028 103 VAL A N   
501  C CA  A VAL A 104 ? 0.34440 0.32141 0.33624 -0.01211 -0.01404 -0.02293 103 VAL A CA  
502  C CA  B VAL A 104 ? 0.34426 0.32124 0.33611 -0.01232 -0.01386 -0.02269 103 VAL A CA  
503  C C   A VAL A 104 ? 0.35411 0.31427 0.34093 -0.01738 -0.00878 -0.02629 103 VAL A C   
504  C C   B VAL A 104 ? 0.35361 0.31417 0.34079 -0.01780 -0.00869 -0.02635 103 VAL A C   
505  O O   A VAL A 104 ? 0.36724 0.32620 0.35650 -0.02079 -0.00999 -0.03426 103 VAL A O   
506  O O   B VAL A 104 ? 0.36729 0.32754 0.35769 -0.02194 -0.00982 -0.03457 103 VAL A O   
507  C CB  A VAL A 104 ? 0.36276 0.34121 0.35127 -0.00234 -0.01805 -0.01985 103 VAL A CB  
508  C CB  B VAL A 104 ? 0.36406 0.34129 0.35172 -0.00219 -0.01743 -0.01849 103 VAL A CB  
509  C CG1 A VAL A 104 ? 0.34431 0.30752 0.32239 0.00345  -0.01429 -0.01186 103 VAL A CG1 
510  C CG1 B VAL A 104 ? 0.33594 0.33036 0.32947 0.00238  -0.02360 -0.01553 103 VAL A CG1 
511  C CG2 A VAL A 104 ? 0.33545 0.33075 0.32958 0.00225  -0.02399 -0.01639 103 VAL A CG2 
512  C CG2 B VAL A 104 ? 0.35703 0.33011 0.34341 -0.00108 -0.01876 -0.02543 103 VAL A CG2 
513  N N   . ILE A 105 ? 0.32441 0.27105 0.30402 -0.01816 -0.00339 -0.02024 104 ILE A N   
514  C CA  . ILE A 105 ? 0.37815 0.30674 0.35157 -0.02239 0.00126  -0.02247 104 ILE A CA  
515  C C   . ILE A 105 ? 0.39623 0.31614 0.36284 -0.01524 -0.00061 -0.02349 104 ILE A C   
516  O O   . ILE A 105 ? 0.40918 0.32748 0.37023 -0.00617 -0.00135 -0.01677 104 ILE A O   
517  C CB  . ILE A 105 ? 0.36984 0.28542 0.33609 -0.02369 0.00717  -0.01501 104 ILE A CB  
518  C CG1 . ILE A 105 ? 0.37864 0.30023 0.35070 -0.03209 0.01014  -0.01524 104 ILE A CG1 
519  C CG2 . ILE A 105 ? 0.36917 0.26333 0.32611 -0.02489 0.01112  -0.01560 104 ILE A CG2 
520  C CD1 . ILE A 105 ? 0.41520 0.33658 0.39351 -0.04242 0.01183  -0.02335 104 ILE A CD1 
521  N N   . ARG A 106 ? 0.37191 0.28657 0.33895 -0.01902 -0.00160 -0.03177 105 ARG A N   
522  C CA  . ARG A 106 ? 0.42092 0.32934 0.38188 -0.01197 -0.00423 -0.03424 105 ARG A CA  
523  C C   . ARG A 106 ? 0.41149 0.29770 0.35965 -0.00888 -0.00014 -0.03110 105 ARG A C   
524  O O   . ARG A 106 ? 0.40025 0.27357 0.34536 -0.01562 0.00398  -0.03131 105 ARG A O   
525  C CB  . ARG A 106 ? 0.41763 0.33021 0.38424 -0.01698 -0.00804 -0.04493 105 ARG A CB  
526  C CG  . ARG A 106 ? 0.44424 0.37934 0.42300 -0.01839 -0.01275 -0.04811 105 ARG A CG  
527  C CD  . ARG A 106 ? 0.53843 0.47830 0.52426 -0.02514 -0.01616 -0.05865 105 ARG A CD  
528  N NE  . ARG A 106 ? 0.67549 0.60933 0.65568 -0.01962 -0.01962 -0.06318 105 ARG A NE  
529  C CZ  . ARG A 106 ? 0.74231 0.67661 0.72592 -0.02395 -0.02320 -0.07241 105 ARG A CZ  
530  N NH1 . ARG A 106 ? 0.69004 0.63123 0.68370 -0.03422 -0.02379 -0.07809 105 ARG A NH1 
531  N NH2 . ARG A 106 ? 0.71402 0.64180 0.69069 -0.01761 -0.02629 -0.07586 105 ARG A NH2 
532  N N   . LEU A 107 ? 0.40301 0.28505 0.34363 0.00165  -0.00126 -0.02782 106 LEU A N   
533  C CA  . LEU A 107 ? 0.40726 0.26818 0.33481 0.00619  0.00200  -0.02566 106 LEU A CA  
534  C C   . LEU A 107 ? 0.46027 0.31031 0.38397 0.00349  0.00015  -0.03520 106 LEU A C   
535  O O   . LEU A 107 ? 0.42991 0.28747 0.35553 0.00711  -0.00427 -0.04028 106 LEU A O   
536  C CB  . LEU A 107 ? 0.40334 0.26519 0.32463 0.01914  0.00167  -0.01805 106 LEU A CB  
537  C CG  . LEU A 107 ? 0.44948 0.29006 0.35651 0.02568  0.00517  -0.01506 106 LEU A CG  
538  C CD1 . LEU A 107 ? 0.45209 0.28043 0.35443 0.02258  0.01043  -0.00859 106 LEU A CD1 
539  C CD2 . LEU A 107 ? 0.47134 0.31633 0.37387 0.03906  0.00393  -0.00929 106 LEU A CD2 
540  N N   . LEU A 108 ? 0.45064 0.28262 0.36868 -0.00297 0.00315  -0.03757 107 LEU A N   
541  C CA  . LEU A 108 ? 0.49801 0.31796 0.41215 -0.00659 0.00079  -0.04669 107 LEU A CA  
542  C C   . LEU A 108 ? 0.54080 0.34107 0.43943 0.00263  0.00138  -0.04604 107 LEU A C   
543  O O   . LEU A 108 ? 0.52559 0.31927 0.41974 0.00423  -0.00217 -0.05328 107 LEU A O   
544  C CB  . LEU A 108 ? 0.49109 0.30217 0.40836 -0.01970 0.00288  -0.05018 107 LEU A CB  
545  C CG  . LEU A 108 ? 0.49672 0.32663 0.42900 -0.02904 0.00300  -0.05088 107 LEU A CG  
546  C CD1 . LEU A 108 ? 0.53186 0.35260 0.46679 -0.04149 0.00605  -0.05267 107 LEU A CD1 
547  C CD2 . LEU A 108 ? 0.52586 0.37368 0.46836 -0.03007 -0.00263 -0.05799 107 LEU A CD2 
548  N N   . ASP A 109 ? 0.48655 0.27697 0.37647 0.00897  0.00567  -0.03761 108 ASP A N   
549  C CA  . ASP A 109 ? 0.54576 0.31688 0.42019 0.01849  0.00695  -0.03606 108 ASP A CA  
550  C C   . ASP A 109 ? 0.56602 0.33439 0.43550 0.02534  0.01159  -0.02494 108 ASP A C   
551  O O   . ASP A 109 ? 0.51916 0.29670 0.39604 0.02087  0.01375  -0.01951 108 ASP A O   
552  C CB  . ASP A 109 ? 0.58579 0.33345 0.45158 0.01197  0.00725  -0.04220 108 ASP A CB  
553  C CG  . ASP A 109 ? 0.69166 0.42018 0.54117 0.02222  0.00651  -0.04401 108 ASP A CG  
554  O OD1 . ASP A 109 ? 0.63889 0.37407 0.48479 0.03411  0.00549  -0.04175 108 ASP A OD1 
555  O OD2 . ASP A 109 ? 0.71435 0.42083 0.55437 0.01844  0.00691  -0.04751 108 ASP A OD2 
556  N N   . TRP A 110 ? 0.50211 0.25752 0.35865 0.03654  0.01301  -0.02154 109 TRP A N   
557  C CA  . TRP A 110 ? 0.58124 0.33171 0.43201 0.04342  0.01741  -0.01097 109 TRP A CA  
558  C C   . TRP A 110 ? 0.63761 0.36549 0.47156 0.05233  0.01934  -0.01038 109 TRP A C   
559  O O   . TRP A 110 ? 0.60655 0.32690 0.43352 0.05649  0.01677  -0.01696 109 TRP A O   
560  C CB  . TRP A 110 ? 0.50682 0.27830 0.36466 0.05165  0.01659  -0.00316 109 TRP A CB  
561  C CG  . TRP A 110 ? 0.55521 0.33324 0.41049 0.06227  0.01363  -0.00473 109 TRP A CG  
562  C CD1 . TRP A 110 ? 0.56419 0.35698 0.42718 0.06118  0.00896  -0.01100 109 TRP A CD1 
563  C CD2 . TRP A 110 ? 0.60764 0.37761 0.45153 0.07591  0.01536  0.00023  109 TRP A CD2 
564  N NE1 . TRP A 110 ? 0.59695 0.39125 0.45379 0.07327  0.00771  -0.01017 109 TRP A NE1 
565  C CE2 . TRP A 110 ? 0.61900 0.39969 0.46415 0.08261  0.01175  -0.00323 109 TRP A CE2 
566  C CE3 . TRP A 110 ? 0.68883 0.44369 0.52144 0.08341  0.01972  0.00742  109 TRP A CE3 
567  C CZ2 . TRP A 110 ? 0.70798 0.48519 0.54353 0.09664  0.01270  0.00048  109 TRP A CZ2 
568  C CZ3 . TRP A 110 ? 0.75487 0.50639 0.57818 0.09746  0.02056  0.01097  109 TRP A CZ3 
569  C CH2 . TRP A 110 ? 0.70898 0.47182 0.53381 0.10401  0.01723  0.00760  109 TRP A CH2 
570  N N   . PHE A 111 ? 0.57385 0.29063 0.40082 0.05559  0.02378  -0.00241 110 PHE A N   
571  C CA  . PHE A 111 ? 0.64531 0.33888 0.45564 0.06367  0.02621  -0.00105 110 PHE A CA  
572  C C   . PHE A 111 ? 0.68310 0.37885 0.48998 0.07423  0.02981  0.01066  110 PHE A C   
573  O O   . PHE A 111 ? 0.61503 0.32219 0.43035 0.07116  0.03131  0.01759  110 PHE A O   
574  C CB  . PHE A 111 ? 0.65427 0.32499 0.45750 0.05420  0.02809  -0.00443 110 PHE A CB  
575  C CG  . PHE A 111 ? 0.77005 0.43782 0.57755 0.04239  0.02454  -0.01516 110 PHE A CG  
576  C CD1 . PHE A 111 ? 0.74557 0.42820 0.56782 0.03000  0.02372  -0.01719 110 PHE A CD1 
577  C CD2 . PHE A 111 ? 0.89987 0.54960 0.69636 0.04383  0.02184  -0.02310 110 PHE A CD2 
578  C CE1 . PHE A 111 ? 0.77080 0.45179 0.59803 0.01903  0.02042  -0.02663 110 PHE A CE1 
579  C CE2 . PHE A 111 ? 0.92540 0.57232 0.72633 0.03260  0.01798  -0.03273 110 PHE A CE2 
580  C CZ  . PHE A 111 ? 0.94744 0.61056 0.76434 0.02003  0.01737  -0.03433 110 PHE A CZ  
581  N N   . GLU A 112 ? 0.61159 0.29581 0.40565 0.08684  0.03113  0.01299  111 GLU A N   
582  C CA  . GLU A 112 ? 0.65228 0.33503 0.44146 0.09707  0.03492  0.02422  111 GLU A CA  
583  C C   . GLU A 112 ? 0.70522 0.36100 0.48012 0.09717  0.03846  0.02510  111 GLU A C   
584  O O   . GLU A 112 ? 0.71208 0.34846 0.47533 0.09763  0.03772  0.01788  111 GLU A O   
585  C CB  . GLU A 112 ? 0.66113 0.35157 0.44640 0.11251  0.03459  0.02808  111 GLU A CB  
586  C CG  . GLU A 112 ? 0.65575 0.34463 0.43616 0.12356  0.03855  0.04018  111 GLU A CG  
587  C CD  . GLU A 112 ? 0.75664 0.45857 0.53678 0.13819  0.03829  0.04555  111 GLU A CD  
588  O OE1 . GLU A 112 ? 0.74681 0.45544 0.52772 0.14062  0.03535  0.03919  111 GLU A OE1 
589  O OE2 . GLU A 112 ? 0.81156 0.52201 0.59347 0.14501  0.04068  0.05539  111 GLU A OE2 
590  N N   . ARG A 113 ? 0.65103 0.30513 0.42656 0.09663  0.04189  0.03388  112 ARG A N   
591  C CA  . ARG A 113 ? 0.70229 0.33224 0.46476 0.09765  0.04555  0.03669  112 ARG A CA  
592  C C   . ARG A 113 ? 0.70387 0.33527 0.46128 0.11174  0.04850  0.04771  112 ARG A C   
593  O O   . ARG A 113 ? 0.70161 0.35424 0.46796 0.11809  0.04754  0.05344  112 ARG A O   
594  C CB  . ARG A 113 ? 0.66232 0.28862 0.43005 0.08394  0.04714  0.03756  112 ARG A CB  
595  C CG  . ARG A 113 ? 0.71280 0.32877 0.48076 0.07078  0.04529  0.02711  112 ARG A CG  
596  C CD  . ARG A 113 ? 0.69933 0.31445 0.47360 0.05773  0.04737  0.02902  112 ARG A CD  
597  N NE  . ARG A 113 ? 0.78327 0.38154 0.55394 0.04632  0.04674  0.02109  112 ARG A NE  
598  C CZ  . ARG A 113 ? 0.73809 0.33269 0.51296 0.03412  0.04871  0.02171  112 ARG A CZ  
599  N NH1 . ARG A 113 ? 0.63727 0.24316 0.41923 0.03183  0.05140  0.02926  112 ARG A NH1 
600  N NH2 . ARG A 113 ? 0.81898 0.39798 0.59062 0.02405  0.04782  0.01483  112 ARG A NH2 
601  N N   . PRO A 114 ? 0.75539 0.37083 0.50176 0.11544  0.05134  0.05026  113 PRO A N   
602  C CA  . PRO A 114 ? 0.77726 0.40899 0.52686 0.12430  0.05299  0.05851  113 PRO A CA  
603  C C   . PRO A 114 ? 0.72440 0.38162 0.49021 0.12177  0.05272  0.06670  113 PRO A C   
604  O O   . PRO A 114 ? 0.81359 0.49304 0.58775 0.12872  0.05189  0.07142  113 PRO A O   
605  C CB  . PRO A 114 ? 0.80043 0.41254 0.53893 0.12313  0.05559  0.05855  113 PRO A CB  
606  C CG  . PRO A 114 ? 0.82855 0.41472 0.55445 0.11935  0.05442  0.04891  113 PRO A CG  
607  C CD  . PRO A 114 ? 0.78018 0.36789 0.51321 0.11066  0.05216  0.04410  113 PRO A CD  
608  N N   . ASP A 115 ? 0.70820 0.36361 0.47925 0.11129  0.05311  0.06815  114 ASP A N   
609  C CA  . ASP A 115 ? 0.69395 0.37219 0.47948 0.10842  0.05233  0.07547  114 ASP A CA  
610  C C   . ASP A 115 ? 0.67298 0.36119 0.46824 0.10116  0.05007  0.07501  114 ASP A C   
611  O O   . ASP A 115 ? 0.66943 0.37460 0.47613 0.09716  0.04888  0.08019  114 ASP A O   
612  C CB  . ASP A 115 ? 0.76356 0.43462 0.54759 0.10335  0.05463  0.07883  114 ASP A CB  
613  C CG  . ASP A 115 ? 0.93854 0.60126 0.71357 0.11094  0.05670  0.07995  114 ASP A CG  
614  O OD1 . ASP A 115 ? 0.84624 0.52445 0.62539 0.11962  0.05615  0.08321  114 ASP A OD1 
615  O OD2 . ASP A 115 ? 0.94310 0.58394 0.70705 0.10794  0.05885  0.07741  114 ASP A OD2 
616  N N   . SER A 116 ? 0.68518 0.36343 0.47632 0.09935  0.04902  0.06851  115 SER A N   
617  C CA  . SER A 116 ? 0.65513 0.34804 0.45874 0.08900  0.04643  0.06542  115 SER A CA  
618  C C   . SER A 116 ? 0.62446 0.32497 0.43207 0.08701  0.04290  0.05537  115 SER A C   
619  O O   . SER A 116 ? 0.60312 0.29180 0.40149 0.09194  0.04284  0.04996  115 SER A O   
620  C CB  . SER A 116 ? 0.59928 0.28151 0.40273 0.07589  0.04843  0.06283  115 SER A CB  
621  O OG  . SER A 116 ? 0.57679 0.23867 0.37079 0.07163  0.04950  0.05466  115 SER A OG  
622  N N   . PHE A 117 ? 0.50786 0.22776 0.32886 0.07990  0.03972  0.05284  116 PHE A N   
623  C CA  . PHE A 117 ? 0.52581 0.25252 0.35203 0.07457  0.03627  0.04234  116 PHE A CA  
624  C C   . PHE A 117 ? 0.58591 0.31117 0.41793 0.05968  0.03634  0.03638  116 PHE A C   
625  O O   . PHE A 117 ? 0.53365 0.26215 0.37005 0.05416  0.03798  0.04130  116 PHE A O   
626  C CB  . PHE A 117 ? 0.51313 0.26465 0.35062 0.07879  0.03218  0.04372  116 PHE A CB  
627  C CG  . PHE A 117 ? 0.56718 0.32138 0.39963 0.09296  0.03173  0.04750  116 PHE A CG  
628  C CD1 . PHE A 117 ? 0.57842 0.33650 0.40970 0.10265  0.03335  0.05899  116 PHE A CD1 
629  C CD2 . PHE A 117 ? 0.60778 0.36086 0.43674 0.09669  0.02969  0.03980  116 PHE A CD2 
630  C CE1 . PHE A 117 ? 0.65457 0.41620 0.48178 0.11594  0.03338  0.06308  116 PHE A CE1 
631  C CE2 . PHE A 117 ? 0.64398 0.40006 0.46792 0.11030  0.02969  0.04358  116 PHE A CE2 
632  C CZ  . PHE A 117 ? 0.61826 0.37898 0.44160 0.11991  0.03177  0.05539  116 PHE A CZ  
633  N N   . VAL A 118 ? 0.51071 0.23089 0.34253 0.05336  0.03454  0.02601  117 VAL A N   
634  C CA  . VAL A 118 ? 0.51399 0.23405 0.35236 0.03909  0.03447  0.01997  117 VAL A CA  
635  C C   . VAL A 118 ? 0.51572 0.25371 0.36525 0.03511  0.02985  0.01236  117 VAL A C   
636  O O   . VAL A 118 ? 0.51883 0.25525 0.36529 0.03933  0.02706  0.00635  117 VAL A O   
637  C CB  . VAL A 118 ? 0.53328 0.22879 0.36155 0.03324  0.03638  0.01464  117 VAL A CB  
638  C CG1 . VAL A 118 ? 0.57498 0.27230 0.41151 0.01824  0.03661  0.00967  117 VAL A CG1 
639  C CG2 . VAL A 118 ? 0.55012 0.22679 0.36609 0.03846  0.04071  0.02213  117 VAL A CG2 
640  N N   . LEU A 119 ? 0.47648 0.23101 0.33828 0.02740  0.02896  0.01257  118 LEU A N   
641  C CA  . LEU A 119 ? 0.45137 0.22446 0.32486 0.02313  0.02458  0.00589  118 LEU A CA  
642  C C   . LEU A 119 ? 0.48705 0.25794 0.36617 0.00937  0.02493  -0.00132 118 LEU A C   
643  O O   . LEU A 119 ? 0.46466 0.23228 0.34521 0.00239  0.02832  0.00191  118 LEU A O   
644  C CB  . LEU A 119 ? 0.40461 0.19982 0.28824 0.02560  0.02270  0.01177  118 LEU A CB  
645  C CG  . LEU A 119 ? 0.51962 0.32495 0.40275 0.03820  0.02040  0.01776  118 LEU A CG  
646  C CD1 . LEU A 119 ? 0.53460 0.32540 0.40596 0.04788  0.02374  0.02548  118 LEU A CD1 
647  C CD2 . LEU A 119 ? 0.47843 0.30435 0.37226 0.03805  0.01798  0.02330  118 LEU A CD2 
648  N N   . ILE A 120 ? 0.47586 0.24911 0.35843 0.00556  0.02139  -0.01071 119 ILE A N   
649  C CA  . ILE A 120 ? 0.47074 0.24431 0.36047 -0.00756 0.02101  -0.01785 119 ILE A CA  
650  C C   . ILE A 120 ? 0.43642 0.23456 0.34062 -0.01106 0.01758  -0.02092 119 ILE A C   
651  O O   . ILE A 120 ? 0.44395 0.25235 0.35119 -0.00630 0.01317  -0.02496 119 ILE A O   
652  C CB  . ILE A 120 ? 0.51742 0.27529 0.40104 -0.01032 0.01886  -0.02651 119 ILE A CB  
653  C CG1 . ILE A 120 ? 0.53216 0.26491 0.39973 -0.00478 0.02158  -0.02355 119 ILE A CG1 
654  C CG2 . ILE A 120 ? 0.53472 0.29294 0.42669 -0.02467 0.01861  -0.03271 119 ILE A CG2 
655  C CD1 . ILE A 120 ? 0.54377 0.26412 0.40779 -0.01056 0.02678  -0.01783 119 ILE A CD1 
656  N N   . LEU A 121 ? 0.45897 0.26615 0.37161 -0.01919 0.01961  -0.01912 120 LEU A N   
657  C CA  . LEU A 121 ? 0.45983 0.29019 0.38545 -0.02183 0.01689  -0.02061 120 LEU A CA  
658  C C   . LEU A 121 ? 0.45955 0.29456 0.39455 -0.03453 0.01722  -0.02705 120 LEU A C   
659  O O   . LEU A 121 ? 0.47080 0.29264 0.40311 -0.04202 0.02088  -0.02723 120 LEU A O   
660  C CB  . LEU A 121 ? 0.43184 0.27113 0.35901 -0.01842 0.01881  -0.01141 120 LEU A CB  
661  C CG  . LEU A 121 ? 0.43575 0.27189 0.35500 -0.00613 0.01849  -0.00369 120 LEU A CG  
662  C CD1 . LEU A 121 ? 0.51637 0.35055 0.43283 -0.00474 0.02197  0.00598  120 LEU A CD1 
663  C CD2 . LEU A 121 ? 0.43662 0.29062 0.36177 0.00095  0.01302  -0.00446 120 LEU A CD2 
664  N N   . GLU A 122 ? 0.42803 0.28241 0.37442 -0.03684 0.01332  -0.03195 121 GLU A N   
665  C CA  . GLU A 122 ? 0.48309 0.34601 0.44031 -0.04825 0.01364  -0.03723 121 GLU A CA  
666  C C   . GLU A 122 ? 0.41787 0.28013 0.37632 -0.05383 0.01918  -0.03132 121 GLU A C   
667  O O   . GLU A 122 ? 0.44058 0.30463 0.39544 -0.04840 0.02109  -0.02367 121 GLU A O   
668  C CB  . GLU A 122 ? 0.42304 0.30892 0.39198 -0.04798 0.00889  -0.04146 121 GLU A CB  
669  C CG  . GLU A 122 ? 0.50700 0.39593 0.47713 -0.04485 0.00320  -0.04881 121 GLU A CG  
670  C CD  . GLU A 122 ? 0.63682 0.54858 0.61898 -0.04539 -0.00133 -0.05281 121 GLU A CD  
671  O OE1 . GLU A 122 ? 0.48237 0.40684 0.46758 -0.04136 -0.00160 -0.04766 121 GLU A OE1 
672  O OE2 . GLU A 122 ? 0.70197 0.61836 0.69031 -0.04996 -0.00492 -0.06110 121 GLU A OE2 
673  N N   . ARG A 123 ? 0.49042 0.35056 0.45423 -0.06482 0.02160  -0.03469 122 ARG A N   
674  C CA  . ARG A 123 ? 0.51514 0.37688 0.48139 -0.07087 0.02705  -0.02963 122 ARG A CA  
675  C C   . ARG A 123 ? 0.49572 0.37255 0.47556 -0.08061 0.02690  -0.03493 122 ARG A C   
676  O O   . ARG A 123 ? 0.46672 0.33742 0.45004 -0.08973 0.02791  -0.03903 122 ARG A O   
677  C CB  . ARG A 123 ? 0.49675 0.33641 0.45349 -0.07452 0.03212  -0.02570 122 ARG A CB  
678  C CG  . ARG A 123 ? 0.54459 0.38552 0.50317 -0.08054 0.03809  -0.02004 122 ARG A CG  
679  C CD  . ARG A 123 ? 0.53623 0.35485 0.48302 -0.08117 0.04294  -0.01414 122 ARG A CD  
680  N NE  . ARG A 123 ? 0.52621 0.32893 0.47072 -0.08807 0.04291  -0.01861 122 ARG A NE  
681  C CZ  . ARG A 123 ? 0.61448 0.41639 0.56555 -0.09966 0.04543  -0.02055 122 ARG A CZ  
682  N NH1 . ARG A 123 ? 0.59650 0.41325 0.55685 -0.10533 0.04871  -0.01865 122 ARG A NH1 
683  N NH2 . ARG A 123 ? 0.58037 0.36613 0.52847 -0.10557 0.04453  -0.02425 122 ARG A NH2 
684  N N   . PRO A 124 ? 0.52221 0.41906 0.51016 -0.07887 0.02532  -0.03492 123 PRO A N   
685  C CA  . PRO A 124 ? 0.49759 0.40920 0.49802 -0.08769 0.02647  -0.03843 123 PRO A CA  
686  C C   . PRO A 124 ? 0.50261 0.40827 0.50196 -0.09437 0.03359  -0.03302 123 PRO A C   
687  O O   . PRO A 124 ? 0.48737 0.38209 0.47701 -0.09070 0.03726  -0.02574 123 PRO A O   
688  C CB  . PRO A 124 ? 0.57401 0.50600 0.58020 -0.08194 0.02314  -0.03829 123 PRO A CB  
689  C CG  . PRO A 124 ? 0.60183 0.52830 0.59787 -0.07102 0.02164  -0.03229 123 PRO A CG  
690  C CD  . PRO A 124 ? 0.54694 0.45445 0.53371 -0.06863 0.02138  -0.03262 123 PRO A CD  
691  N N   . GLU A 125 ? 0.49124 0.40446 0.50096 -0.10436 0.03554  -0.03645 124 GLU A N   
692  C CA  . GLU A 125 ? 0.48590 0.39453 0.49596 -0.11181 0.04249  -0.03169 124 GLU A CA  
693  C C   . GLU A 125 ? 0.56424 0.49282 0.58877 -0.11895 0.04355  -0.03496 124 GLU A C   
694  O O   . GLU A 125 ? 0.57459 0.51159 0.60877 -0.12306 0.03945  -0.04220 124 GLU A O   
695  C CB  . GLU A 125 ? 0.50919 0.39717 0.51441 -0.11855 0.04459  -0.03177 124 GLU A CB  
696  C CG  . GLU A 125 ? 0.68620 0.57204 0.69580 -0.12924 0.05108  -0.02854 124 GLU A CG  
697  C CD  . GLU A 125 ? 0.79046 0.67019 0.79159 -0.12679 0.05751  -0.01946 124 GLU A CD  
698  O OE1 . GLU A 125 ? 0.70669 0.57929 0.69701 -0.11729 0.05677  -0.01541 124 GLU A OE1 
699  O OE2 . GLU A 125 ? 0.81791 0.70021 0.82334 -0.13437 0.06328  -0.01613 124 GLU A OE2 
700  N N   . PRO A 126 ? 0.54736 0.48427 0.57350 -0.11993 0.04872  -0.02988 125 PRO A N   
701  C CA  . PRO A 126 ? 0.46942 0.39855 0.48461 -0.11471 0.05310  -0.02142 125 PRO A CA  
702  C C   . PRO A 126 ? 0.48931 0.42584 0.49994 -0.10349 0.04889  -0.01986 125 PRO A C   
703  O O   . PRO A 126 ? 0.41044 0.36331 0.42866 -0.10090 0.04407  -0.02469 125 PRO A O   
704  C CB  . PRO A 126 ? 0.45328 0.39194 0.47463 -0.12125 0.05956  -0.01838 125 PRO A CB  
705  C CG  . PRO A 126 ? 0.47485 0.43483 0.51070 -0.12435 0.05652  -0.02519 125 PRO A CG  
706  C CD  . PRO A 126 ? 0.55709 0.51305 0.59684 -0.12655 0.05060  -0.03244 125 PRO A CD  
707  N N   A VAL A 127 ? 0.41939 0.34452 0.41801 -0.09700 0.05053  -0.01274 126 VAL A N   
708  N N   B VAL A 127 ? 0.42048 0.34521 0.41897 -0.09677 0.05020  -0.01298 126 VAL A N   
709  C CA  A VAL A 127 ? 0.40584 0.33486 0.39910 -0.08629 0.04591  -0.01027 126 VAL A CA  
710  C CA  B VAL A 127 ? 0.40491 0.33547 0.39888 -0.08637 0.04584  -0.01045 126 VAL A CA  
711  C C   A VAL A 127 ? 0.40095 0.32580 0.38562 -0.08248 0.04973  -0.00177 126 VAL A C   
712  C C   B VAL A 127 ? 0.40112 0.32775 0.38688 -0.08311 0.04995  -0.00210 126 VAL A C   
713  O O   A VAL A 127 ? 0.42582 0.33776 0.40451 -0.08620 0.05566  0.00302  126 VAL A O   
714  O O   B VAL A 127 ? 0.42268 0.33839 0.40382 -0.08770 0.05621  0.00228  126 VAL A O   
715  C CB  A VAL A 127 ? 0.45819 0.37458 0.44436 -0.08042 0.04189  -0.01068 126 VAL A CB  
716  C CB  B VAL A 127 ? 0.45489 0.37485 0.44170 -0.07914 0.04120  -0.01044 126 VAL A CB  
717  C CG1 A VAL A 127 ? 0.49881 0.39336 0.47360 -0.08075 0.04652  -0.00482 126 VAL A CG1 
718  C CG1 B VAL A 127 ? 0.40760 0.33531 0.40215 -0.07974 0.03556  -0.01884 126 VAL A CG1 
719  C CG2 A VAL A 127 ? 0.39496 0.31856 0.37837 -0.07002 0.03636  -0.00864 126 VAL A CG2 
720  C CG2 B VAL A 127 ? 0.50161 0.39931 0.47854 -0.08071 0.04524  -0.00658 126 VAL A CG2 
721  N N   . GLN A 128 ? 0.38952 0.32495 0.37331 -0.07510 0.04592  0.00014  127 GLN A N   
722  C CA  . GLN A 128 ? 0.36005 0.29063 0.33441 -0.06986 0.04773  0.00824  127 GLN A CA  
723  C C   . GLN A 128 ? 0.35308 0.28897 0.32488 -0.06006 0.04047  0.00979  127 GLN A C   
724  O O   . GLN A 128 ? 0.33815 0.28850 0.31768 -0.05837 0.03507  0.00448  127 GLN A O   
725  C CB  . GLN A 128 ? 0.36593 0.30642 0.34280 -0.07288 0.05174  0.00964  127 GLN A CB  
726  C CG  . GLN A 128 ? 0.35942 0.29274 0.32506 -0.06775 0.05382  0.01815  127 GLN A CG  
727  C CD  . GLN A 128 ? 0.44335 0.38549 0.41030 -0.07042 0.05829  0.01939  127 GLN A CD  
728  O OE1 . GLN A 128 ? 0.42330 0.38202 0.39904 -0.07157 0.05661  0.01437  127 GLN A OE1 
729  N NE2 . GLN A 128 ? 0.43622 0.36722 0.39417 -0.07122 0.06420  0.02612  127 GLN A NE2 
730  N N   . ASP A 129 ? 0.33872 0.26308 0.30013 -0.05379 0.04008  0.01718  128 ASP A N   
731  C CA  . ASP A 129 ? 0.33438 0.26497 0.29448 -0.04488 0.03285  0.01929  128 ASP A CA  
732  C C   . ASP A 129 ? 0.32401 0.26679 0.28502 -0.04251 0.03060  0.02088  128 ASP A C   
733  O O   . ASP A 129 ? 0.32008 0.26321 0.27963 -0.04621 0.03545  0.02228  128 ASP A O   
734  C CB  . ASP A 129 ? 0.35524 0.27107 0.30512 -0.03835 0.03221  0.02683  128 ASP A CB  
735  C CG  . ASP A 129 ? 0.43088 0.33701 0.37114 -0.03693 0.03586  0.03520  128 ASP A CG  
736  O OD1 . ASP A 129 ? 0.38790 0.30174 0.32742 -0.03488 0.03412  0.03754  128 ASP A OD1 
737  O OD2 . ASP A 129 ? 0.50862 0.39851 0.44123 -0.03736 0.04014  0.03957  128 ASP A OD2 
738  N N   . LEU A 130 ? 0.30826 0.26130 0.27167 -0.03620 0.02300  0.02050  129 LEU A N   
739  C CA  . LEU A 130 ? 0.27880 0.24411 0.24362 -0.03391 0.01968  0.02065  129 LEU A CA  
740  C C   . LEU A 130 ? 0.30416 0.26116 0.25836 -0.03002 0.02063  0.02917  129 LEU A C   
741  O O   . LEU A 130 ? 0.28593 0.24927 0.23891 -0.02970 0.02059  0.02957  129 LEU A O   
742  C CB  . LEU A 130 ? 0.25226 0.23013 0.22258 -0.02854 0.01069  0.01792  129 LEU A CB  
743  C CG  . LEU A 130 ? 0.28337 0.27398 0.25504 -0.02530 0.00548  0.01760  129 LEU A CG  
744  C CD1 . LEU A 130 ? 0.25500 0.25631 0.23302 -0.03105 0.00909  0.01124  129 LEU A CD1 
745  C CD2 . LEU A 130 ? 0.27230 0.27299 0.24857 -0.01967 -0.00395 0.01612  129 LEU A CD2 
746  N N   . PHE A 131 ? 0.30129 0.24390 0.24729 -0.02676 0.02145  0.03602  130 PHE A N   
747  C CA  . PHE A 131 ? 0.32128 0.25468 0.25684 -0.02375 0.02280  0.04411  130 PHE A CA  
748  C C   . PHE A 131 ? 0.33960 0.26864 0.27234 -0.02997 0.03117  0.04391  130 PHE A C   
749  O O   . PHE A 131 ? 0.33161 0.26310 0.25997 -0.02877 0.03159  0.04626  130 PHE A O   
750  C CB  . PHE A 131 ? 0.32680 0.24522 0.25463 -0.01957 0.02276  0.05144  130 PHE A CB  
751  C CG  . PHE A 131 ? 0.34839 0.25671 0.26536 -0.01651 0.02376  0.05989  130 PHE A CG  
752  C CD1 . PHE A 131 ? 0.36693 0.26313 0.27723 -0.02081 0.03181  0.06246  130 PHE A CD1 
753  C CD2 . PHE A 131 ? 0.34296 0.25406 0.25637 -0.00958 0.01630  0.06527  130 PHE A CD2 
754  C CE1 . PHE A 131 ? 0.43273 0.31947 0.33245 -0.01787 0.03261  0.07009  130 PHE A CE1 
755  C CE2 . PHE A 131 ? 0.36403 0.26519 0.26682 -0.00678 0.01670  0.07301  130 PHE A CE2 
756  C CZ  . PHE A 131 ? 0.38126 0.27035 0.27711 -0.01077 0.02493  0.07522  130 PHE A CZ  
757  N N   . ASP A 132 ? 0.35675 0.27885 0.29152 -0.03654 0.03781  0.04140  131 ASP A N   
758  C CA  . ASP A 132 ? 0.34712 0.26510 0.27988 -0.04302 0.04614  0.04187  131 ASP A CA  
759  C C   . ASP A 132 ? 0.35124 0.28567 0.29175 -0.04625 0.04683  0.03631  131 ASP A C   
760  O O   . ASP A 132 ? 0.36567 0.30071 0.30249 -0.04780 0.05144  0.03854  131 ASP A O   
761  C CB  . ASP A 132 ? 0.34813 0.25582 0.28260 -0.04994 0.05213  0.03998  131 ASP A CB  
762  C CG  . ASP A 132 ? 0.46980 0.35862 0.39429 -0.04721 0.05358  0.04651  131 ASP A CG  
763  O OD1 . ASP A 132 ? 0.46417 0.34673 0.37968 -0.04138 0.05204  0.05356  131 ASP A OD1 
764  O OD2 . ASP A 132 ? 0.53021 0.40997 0.45559 -0.05090 0.05612  0.04457  131 ASP A OD2 
765  N N   . PHE A 133 ? 0.32368 0.27161 0.27476 -0.04702 0.04242  0.02910  132 PHE A N   
766  C CA  . PHE A 133 ? 0.30016 0.26487 0.25949 -0.04959 0.04250  0.02342  132 PHE A CA  
767  C C   . PHE A 133 ? 0.33005 0.30024 0.28343 -0.04347 0.03936  0.02660  132 PHE A C   
768  O O   . PHE A 133 ? 0.33502 0.31115 0.28831 -0.04541 0.04360  0.02613  132 PHE A O   
769  C CB  . PHE A 133 ? 0.27340 0.25047 0.24390 -0.04994 0.03667  0.01570  132 PHE A CB  
770  C CG  . PHE A 133 ? 0.32997 0.32450 0.31049 -0.05329 0.03689  0.00909  132 PHE A CG  
771  C CD1 . PHE A 133 ? 0.33862 0.33682 0.32742 -0.06192 0.04296  0.00479  132 PHE A CD1 
772  C CD2 . PHE A 133 ? 0.30060 0.30791 0.28250 -0.04781 0.03068  0.00734  132 PHE A CD2 
773  C CE1 . PHE A 133 ? 0.35310 0.36842 0.35200 -0.06490 0.04324  -0.00104 132 PHE A CE1 
774  C CE2 . PHE A 133 ? 0.31772 0.34136 0.30875 -0.05037 0.03088  0.00120  132 PHE A CE2 
775  C CZ  . PHE A 133 ? 0.33941 0.36755 0.33931 -0.05889 0.03737  -0.00297 132 PHE A CZ  
776  N N   . ILE A 134 ? 0.31301 0.28132 0.26129 -0.03585 0.03168  0.03000  133 ILE A N   
777  C CA  . ILE A 134 ? 0.30711 0.27921 0.24891 -0.02969 0.02726  0.03309  133 ILE A CA  
778  C C   . ILE A 134 ? 0.33021 0.28961 0.25981 -0.02898 0.03268  0.04030  133 ILE A C   
779  O O   . ILE A 134 ? 0.35603 0.31911 0.28083 -0.02698 0.03340  0.04122  133 ILE A O   
780  C CB  . ILE A 134 ? 0.28125 0.25434 0.22159 -0.02233 0.01699  0.03535  133 ILE A CB  
781  C CG1 . ILE A 134 ? 0.28559 0.27389 0.23764 -0.02253 0.01132  0.02774  133 ILE A CG1 
782  C CG2 . ILE A 134 ? 0.29418 0.26566 0.22481 -0.01576 0.01197  0.04063  133 ILE A CG2 
783  C CD1 . ILE A 134 ? 0.26724 0.25626 0.21962 -0.01626 0.00184  0.03010  133 ILE A CD1 
784  N N   . THR A 135 ? 0.36663 0.31055 0.29041 -0.03028 0.03658  0.04547  134 THR A N   
785  C CA  . THR A 135 ? 0.36305 0.29444 0.27541 -0.03036 0.04246  0.05210  134 THR A CA  
786  C C   . THR A 135 ? 0.40943 0.34625 0.32407 -0.03622 0.05083  0.04944  134 THR A C   
787  O O   . THR A 135 ? 0.40403 0.33946 0.31058 -0.03407 0.05325  0.05275  134 THR A O   
788  C CB  . THR A 135 ? 0.38748 0.30183 0.29467 -0.03191 0.04612  0.05712  134 THR A CB  
789  O OG1 . THR A 135 ? 0.38424 0.29387 0.28861 -0.02555 0.03861  0.06083  134 THR A OG1 
790  C CG2 . THR A 135 ? 0.46769 0.36885 0.36317 -0.03264 0.05277  0.06382  134 THR A CG2 
791  N N   . GLU A 136 ? 0.36073 0.30418 0.28641 -0.04348 0.05514  0.04359  135 GLU A N   
792  C CA  . GLU A 136 ? 0.42339 0.37201 0.35232 -0.04978 0.06372  0.04199  135 GLU A CA  
793  C C   . GLU A 136 ? 0.46571 0.43225 0.39992 -0.04801 0.06194  0.03729  135 GLU A C   
794  O O   . GLU A 136 ? 0.40913 0.37888 0.34024 -0.04885 0.06773  0.03879  135 GLU A O   
795  C CB  . GLU A 136 ? 0.39791 0.34614 0.33683 -0.05877 0.06871  0.03805  135 GLU A CB  
796  C CG  . GLU A 136 ? 0.55576 0.48495 0.48828 -0.06056 0.07120  0.04274  135 GLU A CG  
797  C CD  . GLU A 136 ? 0.65483 0.58161 0.59587 -0.06956 0.07575  0.03902  135 GLU A CD  
798  O OE1 . GLU A 136 ? 0.61444 0.55511 0.56734 -0.07465 0.07659  0.03273  135 GLU A OE1 
799  O OE2 . GLU A 136 ? 0.71343 0.62400 0.64906 -0.07139 0.07808  0.04244  135 GLU A OE2 
800  N N   . ARG A 137 ? 0.41638 0.39459 0.35802 -0.04512 0.05407  0.03181  136 ARG A N   
801  C CA  . ARG A 137 ? 0.40247 0.39811 0.35006 -0.04364 0.05215  0.02660  136 ARG A CA  
802  C C   . ARG A 137 ? 0.40524 0.40185 0.34306 -0.03461 0.04567  0.02917  136 ARG A C   
803  O O   . ARG A 137 ? 0.42104 0.42934 0.36000 -0.03257 0.04562  0.02627  136 ARG A O   
804  C CB  . ARG A 137 ? 0.39922 0.40786 0.36064 -0.04575 0.04700  0.01865  136 ARG A CB  
805  C CG  . ARG A 137 ? 0.56491 0.57218 0.53612 -0.05456 0.05185  0.01537  136 ARG A CG  
806  C CD  . ARG A 137 ? 0.63255 0.65172 0.61353 -0.06161 0.05884  0.01148  136 ARG A CD  
807  N NE  . ARG A 137 ? 0.70407 0.74191 0.69512 -0.06034 0.05409  0.00442  136 ARG A NE  
808  C CZ  . ARG A 137 ? 0.51035 0.55850 0.51498 -0.06595 0.05344  -0.00233 136 ARG A CZ  
809  N NH1 . ARG A 137 ? 0.47878 0.52052 0.48884 -0.07366 0.05727  -0.00322 136 ARG A NH1 
810  N NH2 . ARG A 137 ? 0.46970 0.53446 0.48231 -0.06375 0.04854  -0.00836 136 ARG A NH2 
811  N N   . GLY A 138 ? 0.36763 0.35212 0.29576 -0.02907 0.04005  0.03469  137 GLY A N   
812  C CA  . GLY A 138 ? 0.38395 0.36918 0.30378 -0.02066 0.03186  0.03685  137 GLY A CA  
813  C C   . GLY A 138 ? 0.34181 0.33913 0.27002 -0.01774 0.02217  0.03148  137 GLY A C   
814  O O   . GLY A 138 ? 0.36064 0.36373 0.29992 -0.02158 0.02140  0.02686  137 GLY A O   
815  N N   . ALA A 139 ? 0.33456 0.33519 0.25678 -0.01074 0.01443  0.03214  138 ALA A N   
816  C CA  . ALA A 139 ? 0.30064 0.31332 0.22996 -0.00754 0.00479  0.02719  138 ALA A CA  
817  C C   . ALA A 139 ? 0.34738 0.37606 0.29057 -0.01265 0.00800  0.01851  138 ALA A C   
818  O O   . ALA A 139 ? 0.30918 0.34388 0.25393 -0.01544 0.01513  0.01604  138 ALA A O   
819  C CB  . ALA A 139 ? 0.33852 0.35246 0.25843 0.00007  -0.00262 0.02864  138 ALA A CB  
820  N N   . LEU A 140 ? 0.25591 0.29167 0.20925 -0.01379 0.00277  0.01416  139 LEU A N   
821  C CA  . LEU A 140 ? 0.28253 0.33250 0.24966 -0.01907 0.00518  0.00594  139 LEU A CA  
822  C C   . LEU A 140 ? 0.29387 0.35862 0.26431 -0.01521 -0.00070 0.00061  139 LEU A C   
823  O O   . LEU A 140 ? 0.26404 0.32900 0.22977 -0.00877 -0.01008 0.00192  139 LEU A O   
824  C CB  . LEU A 140 ? 0.21412 0.26412 0.18972 -0.02168 0.00211  0.00352  139 LEU A CB  
825  C CG  . LEU A 140 ? 0.26901 0.30397 0.24139 -0.02487 0.00703  0.00832  139 LEU A CG  
826  C CD1 . LEU A 140 ? 0.27770 0.31438 0.25861 -0.02679 0.00381  0.00472  139 LEU A CD1 
827  C CD2 . LEU A 140 ? 0.28219 0.31247 0.25429 -0.03163 0.01841  0.00896  139 LEU A CD2 
828  N N   . GLN A 141 ? 0.30087 0.37808 0.27977 -0.01924 0.00461  -0.00525 140 GLN A N   
829  C CA  . GLN A 141 ? 0.30203 0.39492 0.28679 -0.01632 -0.00095 -0.01162 140 GLN A CA  
830  C C   . GLN A 141 ? 0.26221 0.35924 0.25281 -0.01435 -0.01098 -0.01465 140 GLN A C   
831  O O   . GLN A 141 ? 0.23304 0.32651 0.22914 -0.01805 -0.01084 -0.01499 140 GLN A O   
832  C CB  . GLN A 141 ? 0.28359 0.39013 0.28022 -0.02247 0.00636  -0.01778 140 GLN A CB  
833  C CG  . GLN A 141 ? 0.39046 0.49552 0.38233 -0.02422 0.01654  -0.01476 140 GLN A CG  
834  C CD  . GLN A 141 ? 0.43301 0.55302 0.43808 -0.03052 0.02358  -0.02023 140 GLN A CD  
835  O OE1 . GLN A 141 ? 0.44511 0.57746 0.46235 -0.03277 0.02000  -0.02690 140 GLN A OE1 
836  N NE2 . GLN A 141 ? 0.59710 0.71621 0.60007 -0.03351 0.03362  -0.01712 140 GLN A NE2 
837  N N   . GLU A 142 ? 0.25852 0.33172 0.29632 0.02252  0.00308  0.00453  141 GLU A N   
838  C CA  . GLU A 142 ? 0.22870 0.28855 0.26219 0.02211  -0.00214 0.00401  141 GLU A CA  
839  C C   . GLU A 142 ? 0.25729 0.32488 0.29824 0.01991  -0.00490 0.00544  141 GLU A C   
840  O O   . GLU A 142 ? 0.26485 0.32321 0.30316 0.01582  -0.00811 0.00624  141 GLU A O   
841  C CB  . GLU A 142 ? 0.24205 0.29089 0.26710 0.03068  -0.00439 0.00104  141 GLU A CB  
842  C CG  . GLU A 142 ? 0.27804 0.31500 0.29353 0.03036  -0.00332 -0.00101 141 GLU A CG  
843  C CD  . GLU A 142 ? 0.32037 0.34157 0.32534 0.03655  -0.00601 -0.00445 141 GLU A CD  
844  O OE1 . GLU A 142 ? 0.29174 0.30494 0.29452 0.03919  -0.00942 -0.00434 141 GLU A OE1 
845  O OE2 . GLU A 142 ? 0.35151 0.36709 0.34910 0.03870  -0.00477 -0.00732 141 GLU A OE2 
846  N N   . GLU A 143 ? 0.24239 0.32803 0.29262 0.02247  -0.00374 0.00564  142 GLU A N   
847  C CA  . GLU A 143 ? 0.23330 0.32856 0.29110 0.01958  -0.00699 0.00665  142 GLU A CA  
848  C C   . GLU A 143 ? 0.24290 0.33616 0.30268 0.00820  -0.00653 0.00834  142 GLU A C   
849  O O   . GLU A 143 ? 0.23541 0.32510 0.29477 0.00468  -0.01043 0.00864  142 GLU A O   
850  C CB  . GLU A 143 ? 0.27813 0.39675 0.34734 0.02337  -0.00543 0.00643  142 GLU A CB  
851  C CG  . GLU A 143 ? 0.27030 0.40253 0.34871 0.01937  -0.00908 0.00708  142 GLU A CG  
852  C CD  . GLU A 143 ? 0.33038 0.48907 0.42184 0.02249  -0.00727 0.00680  142 GLU A CD  
853  O OE1 . GLU A 143 ? 0.26516 0.43649 0.36440 0.01493  -0.00254 0.00780  142 GLU A OE1 
854  O OE2 . GLU A 143 ? 0.36049 0.52710 0.45406 0.03280  -0.01036 0.00580  142 GLU A OE2 
855  N N   . LEU A 144 ? 0.22780 0.32224 0.28842 0.00290  -0.00170 0.00948  143 LEU A N   
856  C CA  . LEU A 144 ? 0.19381 0.28358 0.25461 -0.00696 -0.00079 0.01106  143 LEU A CA  
857  C C   . LEU A 144 ? 0.24461 0.31561 0.29593 -0.00824 -0.00262 0.01108  143 LEU A C   
858  O O   . LEU A 144 ? 0.23663 0.30188 0.28677 -0.01357 -0.00452 0.01141  143 LEU A O   
859  C CB  . LEU A 144 ? 0.18728 0.28238 0.25035 -0.01130 0.00522  0.01293  143 LEU A CB  
860  C CG  . LEU A 144 ? 0.27153 0.35914 0.33303 -0.02072 0.00706  0.01487  143 LEU A CG  
861  C CD1 . LEU A 144 ? 0.23458 0.32805 0.30228 -0.02745 0.00423  0.01421  143 LEU A CD1 
862  C CD2 . LEU A 144 ? 0.24558 0.33740 0.30766 -0.02367 0.01342  0.01745  143 LEU A CD2 
863  N N   . ALA A 145 ? 0.22665 0.28875 0.27113 -0.00356 -0.00205 0.01045  144 ALA A N   
864  C CA  . ALA A 145 ? 0.22654 0.27364 0.26344 -0.00496 -0.00383 0.01036  144 ALA A CA  
865  C C   . ALA A 145 ? 0.22113 0.26269 0.25596 -0.00425 -0.00835 0.00979  144 ALA A C   
866  O O   . ALA A 145 ? 0.23214 0.26530 0.26344 -0.00825 -0.00944 0.01036  144 ALA A O   
867  C CB  . ALA A 145 ? 0.21747 0.25784 0.24797 -0.00051 -0.00318 0.00912  144 ALA A CB  
868  N N   . ARG A 146 ? 0.22037 0.26634 0.25649 0.00165  -0.01081 0.00885  145 ARG A N   
869  C CA  . ARG A 146 ? 0.21958 0.25983 0.25233 0.00320  -0.01527 0.00897  145 ARG A CA  
870  C C   . ARG A 146 ? 0.23566 0.28072 0.27192 -0.00279 -0.01681 0.00976  145 ARG A C   
871  O O   . ARG A 146 ? 0.22079 0.25671 0.25156 -0.00524 -0.01894 0.01029  145 ARG A O   
872  C CB  . ARG A 146 ? 0.22406 0.26928 0.25760 0.01208  -0.01761 0.00816  145 ARG A CB  
873  C CG  . ARG A 146 ? 0.24604 0.28652 0.27565 0.01469  -0.02258 0.00902  145 ARG A CG  
874  C CD  . ARG A 146 ? 0.25193 0.29833 0.28245 0.02523  -0.02504 0.00851  145 ARG A CD  
875  N NE  . ARG A 146 ? 0.30488 0.34093 0.32901 0.03148  -0.02332 0.00707  145 ARG A NE  
876  C CZ  . ARG A 146 ? 0.34256 0.38761 0.37056 0.03710  -0.02055 0.00533  145 ARG A CZ  
877  N NH1 . ARG A 146 ? 0.29189 0.35840 0.33136 0.03792  -0.01903 0.00528  145 ARG A NH1 
878  N NH2 . ARG A 146 ? 0.29235 0.32488 0.31225 0.04151  -0.01909 0.00340  145 ARG A NH2 
879  N N   . SER A 147 ? 0.23157 0.29086 0.27643 -0.00573 -0.01555 0.00966  146 SER A N   
880  C CA  . SER A 147 ? 0.24458 0.30815 0.29231 -0.01228 -0.01739 0.00960  146 SER A CA  
881  C C   . SER A 147 ? 0.24145 0.29305 0.28397 -0.01892 -0.01530 0.01001  146 SER A C   
882  O O   . SER A 147 ? 0.22000 0.26523 0.25800 -0.02175 -0.01763 0.00969  146 SER A O   
883  C CB  . SER A 147 ? 0.23528 0.31679 0.29379 -0.01547 -0.01604 0.00926  146 SER A CB  
884  O OG  . SER A 147 ? 0.23049 0.31411 0.29088 -0.02369 -0.01754 0.00862  146 SER A OG  
885  N N   . PHE A 148 ? 0.19192 0.24039 0.23420 -0.02058 -0.01083 0.01079  147 PHE A N   
886  C CA  . PHE A 148 ? 0.22639 0.26372 0.26353 -0.02497 -0.00866 0.01139  147 PHE A CA  
887  C C   . PHE A 148 ? 0.26879 0.29494 0.29860 -0.02289 -0.01034 0.01135  147 PHE A C   
888  O O   . PHE A 148 ? 0.22581 0.24535 0.25155 -0.02604 -0.01075 0.01117  147 PHE A O   
889  C CB  . PHE A 148 ? 0.19380 0.23024 0.23109 -0.02508 -0.00410 0.01272  147 PHE A CB  
890  C CG  . PHE A 148 ? 0.24165 0.28537 0.28412 -0.02977 -0.00104 0.01362  147 PHE A CG  
891  C CD1 . PHE A 148 ? 0.25470 0.30725 0.30296 -0.03417 -0.00269 0.01267  147 PHE A CD1 
892  C CD2 . PHE A 148 ? 0.25803 0.29984 0.29912 -0.03027 0.00345  0.01560  147 PHE A CD2 
893  C CE1 . PHE A 148 ? 0.31103 0.37026 0.36435 -0.04020 0.00052  0.01360  147 PHE A CE1 
894  C CE2 . PHE A 148 ? 0.27780 0.32467 0.32253 -0.03545 0.00696  0.01710  147 PHE A CE2 
895  C CZ  . PHE A 148 ? 0.28246 0.33798 0.33367 -0.04101 0.00572  0.01607  147 PHE A CZ  
896  N N   . PHE A 149 ? 0.21113 0.23473 0.23870 -0.01793 -0.01098 0.01137  148 PHE A N   
897  C CA  . PHE A 149 ? 0.23302 0.24629 0.25401 -0.01733 -0.01202 0.01159  148 PHE A CA  
898  C C   . PHE A 149 ? 0.24417 0.25424 0.26154 -0.01788 -0.01524 0.01173  148 PHE A C   
899  O O   . PHE A 149 ? 0.24761 0.25067 0.26005 -0.02040 -0.01488 0.01219  148 PHE A O   
900  C CB  . PHE A 149 ? 0.24162 0.25166 0.26024 -0.01281 -0.01252 0.01112  148 PHE A CB  
901  C CG  . PHE A 149 ? 0.21348 0.21364 0.22628 -0.01415 -0.01265 0.01133  148 PHE A CG  
902  C CD1 . PHE A 149 ? 0.24353 0.24274 0.25631 -0.01735 -0.01029 0.01172  148 PHE A CD1 
903  C CD2 . PHE A 149 ? 0.22426 0.21648 0.23169 -0.01210 -0.01497 0.01127  148 PHE A CD2 
904  C CE1 . PHE A 149 ? 0.23561 0.22915 0.24485 -0.01916 -0.01029 0.01183  148 PHE A CE1 
905  C CE2 . PHE A 149 ? 0.25393 0.23790 0.25666 -0.01490 -0.01472 0.01154  148 PHE A CE2 
906  C CZ  . PHE A 149 ? 0.22827 0.21441 0.23276 -0.01873 -0.01240 0.01170  148 PHE A CZ  
907  N N   . TRP A 150 ? 0.22062 0.23676 0.24012 -0.01500 -0.01833 0.01144  149 TRP A N   
908  C CA  . TRP A 150 ? 0.22548 0.23980 0.24085 -0.01496 -0.02202 0.01178  149 TRP A CA  
909  C C   . TRP A 150 ? 0.22307 0.23654 0.23703 -0.02093 -0.02151 0.01112  149 TRP A C   
910  O O   . TRP A 150 ? 0.23017 0.23609 0.23687 -0.02216 -0.02227 0.01160  149 TRP A O   
911  C CB  . TRP A 150 ? 0.21918 0.24436 0.23917 -0.01059 -0.02564 0.01141  149 TRP A CB  
912  C CG  . TRP A 150 ? 0.23195 0.25608 0.24685 -0.00917 -0.03030 0.01201  149 TRP A CG  
913  C CD1 . TRP A 150 ? 0.24567 0.27603 0.26140 -0.01309 -0.03292 0.01099  149 TRP A CD1 
914  C CD2 . TRP A 150 ? 0.24290 0.25799 0.24947 -0.00356 -0.03308 0.01384  149 TRP A CD2 
915  N NE1 . TRP A 150 ? 0.28035 0.30738 0.28871 -0.00962 -0.03741 0.01216  149 TRP A NE1 
916  C CE2 . TRP A 150 ? 0.27773 0.29500 0.28028 -0.00354 -0.03740 0.01431  149 TRP A CE2 
917  C CE3 . TRP A 150 ? 0.27132 0.27551 0.27240 0.00127  -0.03248 0.01508  149 TRP A CE3 
918  C CZ2 . TRP A 150 ? 0.29350 0.30222 0.28631 0.00173  -0.04082 0.01673  149 TRP A CZ2 
919  C CZ3 . TRP A 150 ? 0.27444 0.26854 0.26581 0.00588  -0.03567 0.01734  149 TRP A CZ3 
920  C CH2 . TRP A 150 ? 0.31046 0.30701 0.29770 0.00641  -0.03968 0.01850  149 TRP A CH2 
921  N N   . GLN A 151 ? 0.21868 0.23891 0.23853 -0.02482 -0.01993 0.00997  150 GLN A N   
922  C CA  . GLN A 151 ? 0.23089 0.24796 0.24804 -0.03048 -0.01949 0.00871  150 GLN A CA  
923  C C   . GLN A 151 ? 0.24709 0.25310 0.25821 -0.03155 -0.01596 0.00920  150 GLN A C   
924  O O   . GLN A 151 ? 0.23757 0.23770 0.24253 -0.03379 -0.01605 0.00830  150 GLN A O   
925  C CB  . GLN A 151 ? 0.24230 0.26641 0.26618 -0.03525 -0.01800 0.00759  150 GLN A CB  
926  C CG  . GLN A 151 ? 0.26798 0.30598 0.29865 -0.03601 -0.02187 0.00650  150 GLN A CG  
927  C CD  . GLN A 151 ? 0.32087 0.36519 0.35773 -0.04309 -0.02011 0.00535  150 GLN A CD  
928  O OE1 . GLN A 151 ? 0.28951 0.32481 0.32205 -0.04872 -0.01828 0.00428  150 GLN A OE1 
929  N NE2 . GLN A 151 ? 0.29996 0.35942 0.34662 -0.04285 -0.02028 0.00561  150 GLN A NE2 
930  N N   . VAL A 152 ? 0.23117 0.23537 0.24391 -0.02967 -0.01284 0.01040  151 VAL A N   
931  C CA  . VAL A 152 ? 0.23972 0.23651 0.24815 -0.02991 -0.00981 0.01097  151 VAL A CA  
932  C C   . VAL A 152 ? 0.24000 0.23194 0.24241 -0.02894 -0.01104 0.01165  151 VAL A C   
933  O O   . VAL A 152 ? 0.25994 0.24718 0.25742 -0.03027 -0.00929 0.01151  151 VAL A O   
934  C CB  . VAL A 152 ? 0.23648 0.23441 0.24809 -0.02792 -0.00718 0.01201  151 VAL A CB  
935  C CG1 . VAL A 152 ? 0.25621 0.24966 0.26463 -0.02756 -0.00478 0.01262  151 VAL A CG1 
936  C CG2 . VAL A 152 ? 0.23982 0.24073 0.25536 -0.02926 -0.00496 0.01213  151 VAL A CG2 
937  N N   A LEU A 153 ? 0.22838 0.22064 0.23021 -0.02639 -0.01368 0.01254  152 LEU A N   
938  N N   B LEU A 153 ? 0.22779 0.22006 0.22970 -0.02635 -0.01363 0.01255  152 LEU A N   
939  C CA  A LEU A 153 ? 0.25435 0.24013 0.24905 -0.02615 -0.01455 0.01388  152 LEU A CA  
940  C CA  B LEU A 153 ? 0.25473 0.24063 0.24953 -0.02601 -0.01469 0.01389  152 LEU A CA  
941  C C   A LEU A 153 ? 0.27023 0.25434 0.25900 -0.02753 -0.01627 0.01349  152 LEU A C   
942  C C   B LEU A 153 ? 0.27025 0.25448 0.25921 -0.02757 -0.01619 0.01345  152 LEU A C   
943  O O   A LEU A 153 ? 0.25211 0.23085 0.23411 -0.02882 -0.01477 0.01433  152 LEU A O   
944  O O   B LEU A 153 ? 0.25198 0.23100 0.23446 -0.02899 -0.01446 0.01417  152 LEU A O   
945  C CB  A LEU A 153 ? 0.26055 0.24409 0.25403 -0.02268 -0.01719 0.01503  152 LEU A CB  
946  C CB  B LEU A 153 ? 0.25900 0.24311 0.25267 -0.02232 -0.01765 0.01497  152 LEU A CB  
947  C CG  A LEU A 153 ? 0.25442 0.23739 0.25120 -0.02194 -0.01538 0.01484  152 LEU A CG  
948  C CG  B LEU A 153 ? 0.25897 0.23814 0.25211 -0.02161 -0.01637 0.01563  152 LEU A CG  
949  C CD1 A LEU A 153 ? 0.25346 0.23640 0.25089 -0.01734 -0.01793 0.01463  152 LEU A CD1 
950  C CD1 B LEU A 153 ? 0.27337 0.24375 0.25913 -0.02417 -0.01540 0.01753  152 LEU A CD1 
951  C CD2 A LEU A 153 ? 0.25711 0.23338 0.24957 -0.02460 -0.01351 0.01599  152 LEU A CD2 
952  C CD2 B LEU A 153 ? 0.23403 0.21776 0.23305 -0.02292 -0.01337 0.01449  152 LEU A CD2 
953  N N   . GLU A 154 ? 0.23563 0.22527 0.22666 -0.02752 -0.01943 0.01209  153 GLU A N   
954  C CA  . GLU A 154 ? 0.25291 0.24135 0.23747 -0.02922 -0.02175 0.01103  153 GLU A CA  
955  C C   . GLU A 154 ? 0.28856 0.27256 0.26967 -0.03270 -0.01814 0.00925  153 GLU A C   
956  O O   . GLU A 154 ? 0.26073 0.23970 0.23307 -0.03345 -0.01790 0.00893  153 GLU A O   
957  C CB  . GLU A 154 ? 0.25135 0.24903 0.24046 -0.02937 -0.02634 0.00936  153 GLU A CB  
958  C CG  . GLU A 154 ? 0.25517 0.25753 0.24598 -0.02393 -0.03042 0.01114  153 GLU A CG  
959  C CD  . GLU A 154 ? 0.31459 0.31127 0.29477 -0.02121 -0.03383 0.01300  153 GLU A CD  
960  O OE1 . GLU A 154 ? 0.37883 0.37391 0.35243 -0.02393 -0.03510 0.01181  153 GLU A OE1 
961  O OE2 . GLU A 154 ? 0.29881 0.29129 0.27592 -0.01625 -0.03510 0.01567  153 GLU A OE2 
962  N N   . ALA A 155 ? 0.23525 0.22023 0.22203 -0.03415 -0.01504 0.00823  154 ALA A N   
963  C CA  . ALA A 155 ? 0.28814 0.26732 0.27100 -0.03603 -0.01139 0.00657  154 ALA A CA  
964  C C   . ALA A 155 ? 0.29085 0.26604 0.26959 -0.03415 -0.00758 0.00810  154 ALA A C   
965  O O   . ALA A 155 ? 0.27330 0.24373 0.24493 -0.03442 -0.00544 0.00690  154 ALA A O   
966  C CB  . ALA A 155 ? 0.28810 0.26793 0.27705 -0.03722 -0.00895 0.00597  154 ALA A CB  
967  N N   . VAL A 156 ? 0.24966 0.22739 0.23277 -0.03246 -0.00659 0.01045  155 VAL A N   
968  C CA  . VAL A 156 ? 0.24089 0.21747 0.22182 -0.03186 -0.00311 0.01195  155 VAL A CA  
969  C C   . VAL A 156 ? 0.28338 0.25652 0.25601 -0.03262 -0.00380 0.01314  155 VAL A C   
970  O O   . VAL A 156 ? 0.28291 0.25469 0.25072 -0.03296 -0.00026 0.01345  155 VAL A O   
971  C CB  . VAL A 156 ? 0.29684 0.27707 0.28431 -0.03108 -0.00269 0.01361  155 VAL A CB  
972  C CG1 . VAL A 156 ? 0.29263 0.27348 0.27872 -0.03203 0.00012  0.01523  155 VAL A CG1 
973  C CG2 . VAL A 156 ? 0.28965 0.27306 0.28338 -0.02979 -0.00122 0.01285  155 VAL A CG2 
974  N N   . ARG A 157 ? 0.25791 0.22989 0.22817 -0.03232 -0.00812 0.01410  156 ARG A N   
975  C CA  . ARG A 157 ? 0.28430 0.25164 0.24445 -0.03257 -0.00914 0.01565  156 ARG A CA  
976  C C   . ARG A 157 ? 0.32793 0.29338 0.28063 -0.03334 -0.00832 0.01325  156 ARG A C   
977  O O   . ARG A 157 ? 0.31238 0.27446 0.25645 -0.03376 -0.00576 0.01427  156 ARG A O   
978  C CB  . ARG A 157 ? 0.33057 0.29713 0.28890 -0.03057 -0.01469 0.01693  156 ARG A CB  
979  C CG  . ARG A 157 ? 0.31205 0.27600 0.27266 -0.02919 -0.01525 0.01959  156 ARG A CG  
980  C CD  . ARG A 157 ? 0.32821 0.29088 0.28605 -0.02534 -0.02072 0.02079  156 ARG A CD  
981  N NE  . ARG A 157 ? 0.30040 0.25790 0.24652 -0.02467 -0.02267 0.02273  156 ARG A NE  
982  C CZ  . ARG A 157 ? 0.32618 0.28411 0.26816 -0.02066 -0.02811 0.02360  156 ARG A CZ  
983  N NH1 . ARG A 157 ? 0.29800 0.26245 0.24761 -0.01687 -0.03187 0.02254  156 ARG A NH1 
984  N NH2 . ARG A 157 ? 0.32918 0.28200 0.25896 -0.01995 -0.02976 0.02565  156 ARG A NH2 
985  N N   . HIS A 158 ? 0.29254 0.25961 0.24759 -0.03395 -0.01037 0.00991  157 HIS A N   
986  C CA  . HIS A 158 ? 0.32049 0.28382 0.26732 -0.03512 -0.00995 0.00664  157 HIS A CA  
987  C C   . HIS A 158 ? 0.33645 0.29667 0.28034 -0.03429 -0.00354 0.00604  157 HIS A C   
988  O O   . HIS A 158 ? 0.33006 0.28656 0.26378 -0.03390 -0.00146 0.00523  157 HIS A O   
989  C CB  . HIS A 158 ? 0.29762 0.26241 0.24871 -0.03733 -0.01281 0.00304  157 HIS A CB  
990  C CG  . HIS A 158 ? 0.38456 0.34297 0.32717 -0.03920 -0.01190 -0.00123 157 HIS A CG  
991  N ND1 . HIS A 158 ? 0.34123 0.29746 0.27345 -0.04041 -0.01547 -0.00347 157 HIS A ND1 
992  C CD2 . HIS A 158 ? 0.40940 0.36179 0.35102 -0.03964 -0.00797 -0.00389 157 HIS A CD2 
993  C CE1 . HIS A 158 ? 0.42159 0.37037 0.34662 -0.04203 -0.01369 -0.00789 157 HIS A CE1 
994  N NE2 . HIS A 158 ? 0.38227 0.32783 0.31271 -0.04135 -0.00898 -0.00811 157 HIS A NE2 
995  N N   . CYS A 159 ? 0.31043 0.27303 0.26285 -0.03331 -0.00029 0.00646  158 CYS A N   
996  C CA  . CYS A 159 ? 0.30857 0.27069 0.25975 -0.03117 0.00567  0.00618  158 CYS A CA  
997  C C   . CYS A 159 ? 0.29613 0.26064 0.24318 -0.03105 0.00871  0.00892  158 CYS A C   
998  O O   . CYS A 159 ? 0.31586 0.27881 0.25539 -0.02973 0.01268  0.00790  158 CYS A O   
999  C CB  . CYS A 159 ? 0.28894 0.25518 0.25044 -0.02955 0.00763  0.00710  158 CYS A CB  
1000 S SG  . CYS A 159 ? 0.33586 0.29742 0.30024 -0.02997 0.00605  0.00445  158 CYS A SG  
1001 N N   . HIS A 160 ? 0.27269 0.24044 0.22400 -0.03261 0.00732  0.01240  159 HIS A N   
1002 C CA  . HIS A 160 ? 0.29403 0.26324 0.24149 -0.03401 0.01061  0.01551  159 HIS A CA  
1003 C C   . HIS A 160 ? 0.34129 0.30489 0.27531 -0.03444 0.01019  0.01583  159 HIS A C   
1004 O O   . HIS A 160 ? 0.33600 0.30053 0.26391 -0.03474 0.01508  0.01701  159 HIS A O   
1005 C CB  . HIS A 160 ? 0.30567 0.27598 0.25852 -0.03632 0.00866  0.01882  159 HIS A CB  
1006 C CG  . HIS A 160 ? 0.37137 0.34817 0.33592 -0.03614 0.00961  0.01854  159 HIS A CG  
1007 N ND1 . HIS A 160 ? 0.53655 0.51569 0.50588 -0.03889 0.00972  0.02081  159 HIS A ND1 
1008 C CD2 . HIS A 160 ? 0.44524 0.42594 0.41645 -0.03356 0.01034  0.01626  159 HIS A CD2 
1009 C CE1 . HIS A 160 ? 0.44606 0.43176 0.42480 -0.03785 0.01008  0.01964  159 HIS A CE1 
1010 N NE2 . HIS A 160 ? 0.39243 0.37909 0.37229 -0.03424 0.01059  0.01727  159 HIS A NE2 
1011 N N   . ASN A 161 ? 0.32879 0.28786 0.25800 -0.03431 0.00443  0.01484  160 ASN A N   
1012 C CA  . ASN A 161 ? 0.38018 0.33429 0.29539 -0.03418 0.00314  0.01476  160 ASN A CA  
1013 C C   . ASN A 161 ? 0.42543 0.37786 0.33315 -0.03293 0.00699  0.01086  160 ASN A C   
1014 O O   . ASN A 161 ? 0.38180 0.33122 0.27693 -0.03263 0.00898  0.01131  160 ASN A O   
1015 C CB  . ASN A 161 ? 0.43466 0.38701 0.34771 -0.03380 -0.00456 0.01364  160 ASN A CB  
1016 C CG  . ASN A 161 ? 0.52575 0.47795 0.44227 -0.03333 -0.00835 0.01773  160 ASN A CG  
1017 O OD1 . ASN A 161 ? 0.62978 0.57990 0.54611 -0.03419 -0.00544 0.02174  160 ASN A OD1 
1018 N ND2 . ASN A 161 ? 0.60507 0.55942 0.52454 -0.03202 -0.01477 0.01656  160 ASN A ND2 
1019 N N   . CYS A 162 ? 0.34130 0.29425 0.25500 -0.03180 0.00815  0.00703  161 CYS A N   
1020 C CA  . CYS A 162 ? 0.39935 0.34841 0.30567 -0.02963 0.01208  0.00280  161 CYS A CA  
1021 C C   . CYS A 162 ? 0.41978 0.37386 0.32876 -0.02688 0.01996  0.00406  161 CYS A C   
1022 O O   . CYS A 162 ? 0.38856 0.33975 0.29215 -0.02346 0.02410  0.00058  161 CYS A O   
1023 C CB  . CYS A 162 ? 0.40572 0.35047 0.31584 -0.02967 0.00966  -0.00169 161 CYS A CB  
1024 S SG  . CYS A 162 ? 0.45923 0.40087 0.36641 -0.03369 0.00071  -0.00445 161 CYS A SG  
1025 N N   . GLY A 163 ? 0.35810 0.31986 0.27517 -0.02823 0.02203  0.00866  162 GLY A N   
1026 C CA  . GLY A 163 ? 0.37441 0.34460 0.29585 -0.02640 0.02917  0.01006  162 GLY A CA  
1027 C C   . GLY A 163 ? 0.34554 0.32106 0.27874 -0.02319 0.03080  0.00880  162 GLY A C   
1028 O O   . GLY A 163 ? 0.32750 0.31011 0.26296 -0.01950 0.03671  0.00850  162 GLY A O   
1029 N N   . VAL A 164 ? 0.31532 0.28859 0.25593 -0.02397 0.02590  0.00833  163 VAL A N   
1030 C CA  . VAL A 164 ? 0.29295 0.26859 0.24217 -0.02043 0.02676  0.00716  163 VAL A CA  
1031 C C   . VAL A 164 ? 0.31369 0.29633 0.27494 -0.02275 0.02408  0.01006  163 VAL A C   
1032 O O   . VAL A 164 ? 0.30381 0.28353 0.26622 -0.02628 0.01925  0.01104  163 VAL A O   
1033 C CB  . VAL A 164 ? 0.30866 0.27301 0.25337 -0.01928 0.02396  0.00340  163 VAL A CB  
1034 C CG1 . VAL A 164 ? 0.32228 0.28740 0.27508 -0.01598 0.02455  0.00338  163 VAL A CG1 
1035 C CG2 . VAL A 164 ? 0.31986 0.27583 0.25153 -0.01662 0.02682  -0.00046 163 VAL A CG2 
1036 N N   . LEU A 165 ? 0.28320 0.27539 0.25298 -0.02011 0.02703  0.01109  164 LEU A N   
1037 C CA  . LEU A 165 ? 0.28992 0.28888 0.27036 -0.02164 0.02451  0.01301  164 LEU A CA  
1038 C C   . LEU A 165 ? 0.28794 0.28563 0.27215 -0.01675 0.02411  0.01179  164 LEU A C   
1039 O O   . LEU A 165 ? 0.30043 0.30068 0.28451 -0.01110 0.02786  0.01097  164 LEU A O   
1040 C CB  . LEU A 165 ? 0.32355 0.33601 0.31077 -0.02323 0.02760  0.01523  164 LEU A CB  
1041 C CG  . LEU A 165 ? 0.34393 0.36355 0.34069 -0.02662 0.02469  0.01687  164 LEU A CG  
1042 C CD1 . LEU A 165 ? 0.31711 0.32896 0.31040 -0.03260 0.02092  0.01818  164 LEU A CD1 
1043 C CD2 . LEU A 165 ? 0.30257 0.33824 0.30706 -0.02764 0.02841  0.01816  164 LEU A CD2 
1044 N N   . HIS A 166 ? 0.25808 0.25163 0.24499 -0.01837 0.01990  0.01194  165 HIS A N   
1045 C CA  . HIS A 166 ? 0.25706 0.24711 0.24557 -0.01439 0.01974  0.01137  165 HIS A CA  
1046 C C   . HIS A 166 ? 0.25921 0.26016 0.25550 -0.01039 0.02107  0.01300  165 HIS A C   
1047 O O   . HIS A 166 ? 0.29179 0.29181 0.28726 -0.00419 0.02346  0.01284  165 HIS A O   
1048 C CB  . HIS A 166 ? 0.29122 0.27574 0.28066 -0.01776 0.01545  0.01137  165 HIS A CB  
1049 C CG  . HIS A 166 ? 0.32035 0.29922 0.30973 -0.01510 0.01567  0.01125  165 HIS A CG  
1050 N ND1 . HIS A 166 ? 0.29930 0.28343 0.29387 -0.01165 0.01605  0.01311  165 HIS A ND1 
1051 C CD2 . HIS A 166 ? 0.30749 0.27530 0.29148 -0.01594 0.01558  0.00971  165 HIS A CD2 
1052 C CE1 . HIS A 166 ? 0.31761 0.29331 0.30934 -0.01004 0.01656  0.01329  165 HIS A CE1 
1053 N NE2 . HIS A 166 ? 0.29674 0.26219 0.28235 -0.01313 0.01643  0.01117  165 HIS A NE2 
1054 N N   . ARG A 167 ? 0.27619 0.28686 0.27937 -0.01369 0.01917  0.01447  166 ARG A N   
1055 C CA  . ARG A 167 ? 0.25179 0.27553 0.26309 -0.01144 0.01930  0.01567  166 ARG A CA  
1056 C C   . ARG A 167 ? 0.25703 0.27955 0.27018 -0.00744 0.01740  0.01628  166 ARG A C   
1057 O O   . ARG A 167 ? 0.27150 0.30486 0.29023 -0.00405 0.01720  0.01720  166 ARG A O   
1058 C CB  . ARG A 167 ? 0.24575 0.27962 0.25911 -0.00676 0.02376  0.01573  166 ARG A CB  
1059 C CG  . ARG A 167 ? 0.25592 0.29415 0.26818 -0.01132 0.02644  0.01577  166 ARG A CG  
1060 C CD  . ARG A 167 ? 0.29447 0.34996 0.31333 -0.00833 0.03048  0.01636  166 ARG A CD  
1061 N NE  . ARG A 167 ? 0.29283 0.34778 0.30854 0.00119  0.03440  0.01535  166 ARG A NE  
1062 C CZ  . ARG A 167 ? 0.37835 0.44842 0.39892 0.00620  0.03874  0.01554  166 ARG A CZ  
1063 N NH1 . ARG A 167 ? 0.31753 0.40614 0.34749 0.00142  0.03975  0.01680  166 ARG A NH1 
1064 N NH2 . ARG A 167 ? 0.29019 0.35675 0.30604 0.01617  0.04230  0.01436  166 ARG A NH2 
1065 N N   . ASP A 168 ? 0.22735 0.23808 0.23601 -0.00799 0.01594  0.01600  167 ASP A N   
1066 C CA  . ASP A 168 ? 0.25683 0.26615 0.26635 -0.00484 0.01467  0.01723  167 ASP A CA  
1067 C C   . ASP A 168 ? 0.26896 0.27022 0.27655 -0.00905 0.01231  0.01700  167 ASP A C   
1068 O O   . ASP A 168 ? 0.27603 0.26983 0.28058 -0.00757 0.01283  0.01774  167 ASP A O   
1069 C CB  . ASP A 168 ? 0.28784 0.29114 0.29293 0.00228  0.01768  0.01790  167 ASP A CB  
1070 C CG  . ASP A 168 ? 0.37274 0.37735 0.37861 0.00691  0.01676  0.02022  167 ASP A CG  
1071 O OD1 . ASP A 168 ? 0.28596 0.29985 0.29688 0.00528  0.01388  0.02088  167 ASP A OD1 
1072 O OD2 . ASP A 168 ? 0.34419 0.33919 0.34427 0.01226  0.01893  0.02139  167 ASP A OD2 
1073 N N   . ILE A 169 ? 0.25836 0.26115 0.26754 -0.01419 0.00993  0.01621  168 ILE A N   
1074 C CA  . ILE A 169 ? 0.26481 0.26312 0.27353 -0.01715 0.00757  0.01594  168 ILE A CA  
1075 C C   . ILE A 169 ? 0.23783 0.23996 0.24922 -0.01521 0.00652  0.01706  168 ILE A C   
1076 O O   . ILE A 169 ? 0.23518 0.24475 0.24971 -0.01469 0.00514  0.01712  168 ILE A O   
1077 C CB  . ILE A 169 ? 0.26311 0.26201 0.27218 -0.02129 0.00514  0.01514  168 ILE A CB  
1078 C CG1 . ILE A 169 ? 0.26455 0.25954 0.26929 -0.02298 0.00621  0.01441  168 ILE A CG1 
1079 C CG2 . ILE A 169 ? 0.26230 0.25879 0.27177 -0.02277 0.00271  0.01480  168 ILE A CG2 
1080 C CD1 . ILE A 169 ? 0.29524 0.29077 0.29907 -0.02633 0.00447  0.01465  168 ILE A CD1 
1081 N N   . LYS A 170 ? 0.22800 0.22508 0.23756 -0.01464 0.00724  0.01788  169 LYS A N   
1082 C CA  . LYS A 170 ? 0.26525 0.26523 0.27575 -0.01284 0.00675  0.01924  169 LYS A CA  
1083 C C   . LYS A 170 ? 0.25126 0.24524 0.25993 -0.01478 0.00801  0.02001  169 LYS A C   
1084 O O   . LYS A 170 ? 0.25275 0.24002 0.25926 -0.01722 0.00912  0.01940  169 LYS A O   
1085 C CB  . LYS A 170 ? 0.26132 0.26429 0.27093 -0.00749 0.00786  0.02108  169 LYS A CB  
1086 C CG  . LYS A 170 ? 0.25318 0.24839 0.25843 -0.00404 0.01100  0.02238  169 LYS A CG  
1087 C CD  . LYS A 170 ? 0.24233 0.24104 0.24621 0.00292  0.01159  0.02490  169 LYS A CD  
1088 C CE  . LYS A 170 ? 0.30174 0.29163 0.30024 0.00831  0.01480  0.02623  169 LYS A CE  
1089 N NZ  . LYS A 170 ? 0.30632 0.30016 0.30302 0.01639  0.01482  0.02928  169 LYS A NZ  
1090 N N   . ASP A 171 ? 0.21306 0.20992 0.22228 -0.01409 0.00801  0.02121  170 ASP A N   
1091 C CA  . ASP A 171 ? 0.23065 0.22412 0.23930 -0.01694 0.00975  0.02220  170 ASP A CA  
1092 C C   . ASP A 171 ? 0.27738 0.26068 0.28108 -0.01708 0.01292  0.02412  170 ASP A C   
1093 O O   . ASP A 171 ? 0.25009 0.22815 0.25317 -0.02181 0.01409  0.02383  170 ASP A O   
1094 C CB  . ASP A 171 ? 0.22439 0.22356 0.23382 -0.01569 0.01007  0.02338  170 ASP A CB  
1095 C CG  . ASP A 171 ? 0.30330 0.30350 0.30903 -0.01068 0.01072  0.02557  170 ASP A CG  
1096 O OD1 . ASP A 171 ? 0.25258 0.24984 0.25586 -0.00759 0.01103  0.02661  170 ASP A OD1 
1097 O OD2 . ASP A 171 ? 0.27808 0.28298 0.28307 -0.00923 0.01083  0.02616  170 ASP A OD2 
1098 N N   . GLU A 172 ? 0.24000 0.22010 0.23985 -0.01191 0.01412  0.02587  171 GLU A N   
1099 C CA  . GLU A 172 ? 0.28223 0.24972 0.27549 -0.01069 0.01727  0.02779  171 GLU A CA  
1100 C C   . GLU A 172 ? 0.27092 0.23028 0.26225 -0.01389 0.01764  0.02508  171 GLU A C   
1101 O O   . GLU A 172 ? 0.29737 0.24373 0.28273 -0.01569 0.02010  0.02566  171 GLU A O   
1102 C CB  . GLU A 172 ? 0.26493 0.23188 0.25460 -0.00265 0.01797  0.02998  171 GLU A CB  
1103 C CG  . GLU A 172 ? 0.27856 0.25311 0.26818 0.00142  0.01714  0.03262  171 GLU A CG  
1104 C CD  . GLU A 172 ? 0.35556 0.33042 0.34166 0.00992  0.01731  0.03481  171 GLU A CD  
1105 O OE1 . GLU A 172 ? 0.36637 0.32840 0.34506 0.01341  0.02021  0.03745  171 GLU A OE1 
1106 O OE2 . GLU A 172 ? 0.34663 0.33437 0.33720 0.01307  0.01443  0.03378  171 GLU A OE2 
1107 N N   . ASN A 173 ? 0.25536 0.22078 0.25023 -0.01465 0.01538  0.02215  172 ASN A N   
1108 C CA  . ASN A 173 ? 0.28487 0.24332 0.27652 -0.01685 0.01562  0.01938  172 ASN A CA  
1109 C C   . ASN A 173 ? 0.28002 0.24027 0.27424 -0.02386 0.01329  0.01699  172 ASN A C   
1110 O O   . ASN A 173 ? 0.29304 0.25158 0.28543 -0.02560 0.01216  0.01434  172 ASN A O   
1111 C CB  . ASN A 173 ? 0.27915 0.24291 0.27157 -0.01266 0.01533  0.01820  172 ASN A CB  
1112 C CG  . ASN A 173 ? 0.34906 0.31049 0.33831 -0.00509 0.01786  0.02003  172 ASN A CG  
1113 O OD1 . ASN A 173 ? 0.33084 0.28115 0.31423 -0.00300 0.02011  0.02167  172 ASN A OD1 
1114 N ND2 . ASN A 173 ? 0.28419 0.25622 0.27722 -0.00095 0.01752  0.02001  172 ASN A ND2 
1115 N N   . ILE A 174 ? 0.25946 0.22399 0.25758 -0.02742 0.01264  0.01798  173 ILE A N   
1116 C CA  . ILE A 174 ? 0.27879 0.24793 0.28073 -0.03330 0.01019  0.01600  173 ILE A CA  
1117 C C   . ILE A 174 ? 0.29743 0.26262 0.29921 -0.03863 0.01212  0.01701  173 ILE A C   
1118 O O   . ILE A 174 ? 0.30152 0.26855 0.30443 -0.03770 0.01435  0.01998  173 ILE A O   
1119 C CB  . ILE A 174 ? 0.27086 0.25261 0.27936 -0.03201 0.00751  0.01606  173 ILE A CB  
1120 C CG1 . ILE A 174 ? 0.26729 0.25112 0.27518 -0.02880 0.00565  0.01502  173 ILE A CG1 
1121 C CG2 . ILE A 174 ? 0.28328 0.27160 0.29647 -0.03670 0.00519  0.01463  173 ILE A CG2 
1122 C CD1 . ILE A 174 ? 0.27478 0.26704 0.28681 -0.02654 0.00358  0.01535  173 ILE A CD1 
1123 N N   . LEU A 175 ? 0.30070 0.26053 0.30052 -0.04472 0.01134  0.01454  174 LEU A N   
1124 C CA  . LEU A 175 ? 0.27876 0.23556 0.27917 -0.05206 0.01296  0.01506  174 LEU A CA  
1125 C C   . LEU A 175 ? 0.29491 0.26700 0.30447 -0.05694 0.00985  0.01360  174 LEU A C   
1126 O O   . LEU A 175 ? 0.31991 0.29826 0.33155 -0.05657 0.00578  0.01087  174 LEU A O   
1127 C CB  . LEU A 175 ? 0.29301 0.23347 0.28495 -0.05675 0.01383  0.01264  174 LEU A CB  
1128 C CG  . LEU A 175 ? 0.33803 0.26159 0.31980 -0.05099 0.01735  0.01401  174 LEU A CG  
1129 C CD1 . LEU A 175 ? 0.39240 0.29773 0.36456 -0.05611 0.01825  0.01093  174 LEU A CD1 
1130 C CD2 . LEU A 175 ? 0.33124 0.25209 0.31201 -0.04777 0.02114  0.01915  174 LEU A CD2 
1131 N N   . ILE A 176 ? 0.27249 0.25109 0.28719 -0.06109 0.01195  0.01569  175 ILE A N   
1132 C CA  . ILE A 176 ? 0.24866 0.24398 0.27323 -0.06564 0.00957  0.01444  175 ILE A CA  
1133 C C   . ILE A 176 ? 0.31470 0.30679 0.33965 -0.07658 0.01008  0.01299  175 ILE A C   
1134 O O   . ILE A 176 ? 0.34167 0.32527 0.36359 -0.08126 0.01462  0.01552  175 ILE A O   
1135 C CB  . ILE A 176 ? 0.28757 0.29588 0.31885 -0.06279 0.01196  0.01747  175 ILE A CB  
1136 C CG1 . ILE A 176 ? 0.28750 0.29672 0.31692 -0.05292 0.01154  0.01856  175 ILE A CG1 
1137 C CG2 . ILE A 176 ? 0.31143 0.33912 0.35370 -0.06601 0.00953  0.01594  175 ILE A CG2 
1138 C CD1 . ILE A 176 ? 0.27005 0.28623 0.30164 -0.04997 0.01520  0.02176  175 ILE A CD1 
1139 N N   . ASP A 177 ? 0.33287 0.33132 0.36085 -0.08100 0.00530  0.00900  176 ASP A N   
1140 C CA  . ASP A 177 ? 0.35022 0.35202 0.38181 -0.09262 0.00454  0.00694  176 ASP A CA  
1141 C C   . ASP A 177 ? 0.38326 0.40755 0.42817 -0.09477 0.00524  0.00877  176 ASP A C   
1142 O O   . ASP A 177 ? 0.34074 0.38296 0.39386 -0.09083 0.00113  0.00748  176 ASP A O   
1143 C CB  . ASP A 177 ? 0.37120 0.37365 0.40088 -0.09582 -0.00158 0.00174  176 ASP A CB  
1144 C CG  . ASP A 177 ? 0.42088 0.42703 0.45402 -0.10912 -0.00328 -0.00131 176 ASP A CG  
1145 O OD1 . ASP A 177 ? 0.40383 0.42477 0.44746 -0.11510 -0.00166 0.00034  176 ASP A OD1 
1146 O OD2 . ASP A 177 ? 0.41782 0.41275 0.44307 -0.11390 -0.00626 -0.00565 176 ASP A OD2 
1147 N N   . LEU A 178 ? 0.33394 0.35692 0.38028 -0.10039 0.01081  0.01205  177 LEU A N   
1148 C CA  . LEU A 178 ? 0.35194 0.39604 0.40990 -0.10063 0.01323  0.01458  177 LEU A CA  
1149 C C   . LEU A 178 ? 0.41978 0.48567 0.49041 -0.10855 0.00964  0.01168  177 LEU A C   
1150 O O   . LEU A 178 ? 0.44850 0.53694 0.53047 -0.10522 0.00962  0.01250  177 LEU A O   
1151 C CB  . LEU A 178 ? 0.36149 0.39739 0.41602 -0.10505 0.02076  0.01940  177 LEU A CB  
1152 C CG  . LEU A 178 ? 0.43443 0.45439 0.47823 -0.09537 0.02417  0.02300  177 LEU A CG  
1153 C CD1 . LEU A 178 ? 0.40009 0.40690 0.43710 -0.10080 0.03116  0.02791  177 LEU A CD1 
1154 C CD2 . LEU A 178 ? 0.35528 0.39013 0.40412 -0.08436 0.02369  0.02403  177 LEU A CD2 
1155 N N   . ASN A 179 ? 0.40878 0.46917 0.47767 -0.11879 0.00653  0.00806  178 ASN A N   
1156 C CA  . ASN A 179 ? 0.37146 0.45513 0.45326 -0.12679 0.00231  0.00501  178 ASN A CA  
1157 C C   . ASN A 179 ? 0.35075 0.44634 0.43556 -0.11923 -0.00574 0.00138  178 ASN A C   
1158 O O   . ASN A 179 ? 0.34917 0.47068 0.44700 -0.11837 -0.00903 0.00050  178 ASN A O   
1159 C CB  . ASN A 179 ? 0.45135 0.52553 0.53033 -0.14273 0.00199  0.00221  178 ASN A CB  
1160 C CG  . ASN A 179 ? 0.51444 0.58483 0.59481 -0.15301 0.00983  0.00626  178 ASN A CG  
1161 O OD1 . ASN A 179 ? 0.68078 0.73683 0.75574 -0.16604 0.01107  0.00486  178 ASN A OD1 
1162 N ND2 . ASN A 179 ? 0.50880 0.59044 0.59497 -0.14729 0.01534  0.01128  178 ASN A ND2 
1163 N N   . ARG A 180 ? 0.32183 0.39954 0.39463 -0.11305 -0.00871 -0.00036 179 ARG A N   
1164 C CA  . ARG A 180 ? 0.33439 0.42053 0.40757 -0.10606 -0.01599 -0.00314 179 ARG A CA  
1165 C C   . ARG A 180 ? 0.31875 0.40879 0.39231 -0.09177 -0.01583 -0.00041 179 ARG A C   
1166 O O   . ARG A 180 ? 0.27745 0.37712 0.35274 -0.08528 -0.02148 -0.00173 179 ARG A O   
1167 C CB  . ARG A 180 ? 0.38528 0.45099 0.44465 -0.10785 -0.01920 -0.00672 179 ARG A CB  
1168 C CG  . ARG A 180 ? 0.40932 0.47029 0.46683 -0.12221 -0.02082 -0.01081 179 ARG A CG  
1169 C CD  . ARG A 180 ? 0.44135 0.48296 0.48414 -0.12285 -0.02433 -0.01516 179 ARG A CD  
1170 N NE  . ARG A 180 ? 0.52854 0.57886 0.57000 -0.11446 -0.03071 -0.01667 179 ARG A NE  
1171 C CZ  . ARG A 180 ? 0.60811 0.67627 0.65513 -0.11738 -0.03810 -0.01992 179 ARG A CZ  
1172 N NH1 . ARG A 180 ? 0.55612 0.63781 0.61207 -0.12929 -0.04044 -0.02261 179 ARG A NH1 
1173 N NH2 . ARG A 180 ? 0.60439 0.67734 0.64776 -0.10834 -0.04336 -0.02027 179 ARG A NH2 
1174 N N   . GLY A 181 ? 0.28797 0.37013 0.35911 -0.08689 -0.00979 0.00330  180 GLY A N   
1175 C CA  . GLY A 181 ? 0.27700 0.36025 0.34702 -0.07447 -0.00972 0.00525  180 GLY A CA  
1176 C C   . GLY A 181 ? 0.34453 0.41214 0.40352 -0.06851 -0.01256 0.00426  180 GLY A C   
1177 O O   . GLY A 181 ? 0.31446 0.38496 0.37287 -0.05958 -0.01483 0.00484  180 GLY A O   
1178 N N   . GLU A 182 ? 0.28026 0.33072 0.32988 -0.07323 -0.01207 0.00283  181 GLU A N   
1179 C CA  . GLU A 182 ? 0.31657 0.35322 0.35568 -0.06837 -0.01396 0.00183  181 GLU A CA  
1180 C C   . GLU A 182 ? 0.31049 0.33051 0.34198 -0.06538 -0.00870 0.00398  181 GLU A C   
1181 O O   . GLU A 182 ? 0.32370 0.33558 0.35332 -0.07003 -0.00454 0.00492  181 GLU A O   
1182 C CB  . GLU A 182 ? 0.30874 0.33958 0.34190 -0.07469 -0.01780 -0.00217 181 GLU A CB  
1183 C CG  . GLU A 182 ? 0.36932 0.41765 0.40902 -0.07661 -0.02436 -0.00451 181 GLU A CG  
1184 C CD  . GLU A 182 ? 0.51590 0.55931 0.54946 -0.08445 -0.02847 -0.00911 181 GLU A CD  
1185 O OE1 . GLU A 182 ? 0.49950 0.52607 0.52505 -0.09004 -0.02546 -0.01073 181 GLU A OE1 
1186 O OE2 . GLU A 182 ? 0.55686 0.61288 0.59284 -0.08459 -0.03495 -0.01127 181 GLU A OE2 
1187 N N   . LEU A 183 ? 0.25762 0.27286 0.28459 -0.05768 -0.00899 0.00496  182 LEU A N   
1188 C CA  . LEU A 183 ? 0.24640 0.24909 0.26711 -0.05386 -0.00490 0.00678  182 LEU A CA  
1189 C C   . LEU A 183 ? 0.28237 0.27210 0.29341 -0.05405 -0.00526 0.00473  182 LEU A C   
1190 O O   . LEU A 183 ? 0.31004 0.30125 0.31839 -0.05418 -0.00907 0.00260  182 LEU A O   
1191 C CB  . LEU A 183 ? 0.23152 0.23844 0.25397 -0.04626 -0.00481 0.00884  182 LEU A CB  
1192 C CG  . LEU A 183 ? 0.30807 0.32172 0.33610 -0.04444 -0.00194 0.01124  182 LEU A CG  
1193 C CD1 . LEU A 183 ? 0.34042 0.36711 0.37669 -0.04840 -0.00267 0.01087  182 LEU A CD1 
1194 C CD2 . LEU A 183 ? 0.30184 0.31820 0.33015 -0.03738 -0.00260 0.01221  182 LEU A CD2 
1195 N N   . LYS A 184 ? 0.28673 0.26387 0.29183 -0.05339 -0.00115 0.00547  183 LYS A N   
1196 C CA  . LYS A 184 ? 0.31089 0.27514 0.30624 -0.05264 -0.00035 0.00336  183 LYS A CA  
1197 C C   . LYS A 184 ? 0.30828 0.26662 0.30036 -0.04586 0.00345  0.00564  183 LYS A C   
1198 O O   . LYS A 184 ? 0.28915 0.24498 0.28235 -0.04436 0.00657  0.00823  183 LYS A O   
1199 C CB  . LYS A 184 ? 0.34011 0.29256 0.32985 -0.05927 0.00082  0.00095  183 LYS A CB  
1200 C CG  . LYS A 184 ? 0.38868 0.34823 0.38253 -0.06772 -0.00304 -0.00170 183 LYS A CG  
1201 C CD  . LYS A 184 ? 0.46888 0.43086 0.45873 -0.06822 -0.00790 -0.00535 183 LYS A CD  
1202 C CE  . LYS A 184 ? 0.51052 0.47722 0.50231 -0.07759 -0.01206 -0.00902 183 LYS A CE  
1203 N NZ  . LYS A 184 ? 0.53147 0.50315 0.51938 -0.07685 -0.01766 -0.01205 183 LYS A NZ  
1204 N N   A LEU A 185 ? 0.31328 0.27046 0.30129 -0.04182 0.00319  0.00488  184 LEU A N   
1205 N N   B LEU A 185 ? 0.31360 0.27038 0.30138 -0.04190 0.00325  0.00481  184 LEU A N   
1206 C CA  A LEU A 185 ? 0.30275 0.25710 0.28867 -0.03561 0.00656  0.00664  184 LEU A CA  
1207 C CA  B LEU A 185 ? 0.30295 0.25750 0.28894 -0.03560 0.00651  0.00664  184 LEU A CA  
1208 C C   A LEU A 185 ? 0.32488 0.26534 0.30260 -0.03421 0.01007  0.00553  184 LEU A C   
1209 C C   B LEU A 185 ? 0.32473 0.26556 0.30239 -0.03385 0.01007  0.00551  184 LEU A C   
1210 O O   A LEU A 185 ? 0.33670 0.26824 0.30739 -0.03726 0.00968  0.00221  184 LEU A O   
1211 O O   B LEU A 185 ? 0.33377 0.26605 0.30418 -0.03634 0.00975  0.00218  184 LEU A O   
1212 C CB  A LEU A 185 ? 0.30269 0.26163 0.28742 -0.03270 0.00575  0.00634  184 LEU A CB  
1213 C CB  B LEU A 185 ? 0.30187 0.26183 0.28726 -0.03300 0.00533  0.00641  184 LEU A CB  
1214 C CG  A LEU A 185 ? 0.27456 0.24341 0.26442 -0.03339 0.00228  0.00732  184 LEU A CG  
1215 C CG  B LEU A 185 ? 0.31062 0.27663 0.29916 -0.02818 0.00695  0.00873  184 LEU A CG  
1216 C CD1 A LEU A 185 ? 0.29067 0.26114 0.27767 -0.03108 0.00275  0.00774  184 LEU A CD1 
1217 C CD1 B LEU A 185 ? 0.27651 0.25020 0.27243 -0.02770 0.00572  0.01095  184 LEU A CD1 
1218 C CD2 A LEU A 185 ? 0.27606 0.25170 0.27337 -0.03203 0.00218  0.00971  184 LEU A CD2 
1219 C CD2 B LEU A 185 ? 0.29090 0.26003 0.27715 -0.02822 0.00591  0.00827  184 LEU A CD2 
1220 N N   . ILE A 186 ? 0.29454 0.23262 0.27217 -0.02891 0.01329  0.00814  185 ILE A N   
1221 C CA  . ILE A 186 ? 0.33078 0.25490 0.29985 -0.02507 0.01695  0.00763  185 ILE A CA  
1222 C C   . ILE A 186 ? 0.34838 0.27751 0.31820 -0.01639 0.01928  0.00939  185 ILE A C   
1223 O O   . ILE A 186 ? 0.33504 0.27781 0.31228 -0.01469 0.01803  0.01116  185 ILE A O   
1224 C CB  . ILE A 186 ? 0.32712 0.24030 0.29335 -0.02685 0.01896  0.00957  185 ILE A CB  
1225 C CG1 . ILE A 186 ? 0.30234 0.22519 0.27563 -0.02441 0.01919  0.01402  185 ILE A CG1 
1226 C CG2 . ILE A 186 ? 0.34476 0.25271 0.30992 -0.03651 0.01717  0.00723  185 ILE A CG2 
1227 C CD1 . ILE A 186 ? 0.33237 0.24388 0.30118 -0.02458 0.02212  0.01718  185 ILE A CD1 
1228 N N   . ASP A 187 ? 0.32040 0.23813 0.28210 -0.01095 0.02265  0.00854  186 ASP A N   
1229 C CA  . ASP A 187 ? 0.31154 0.23292 0.27333 -0.00136 0.02548  0.01039  186 ASP A CA  
1230 C C   . ASP A 187 ? 0.36473 0.30126 0.33175 0.00077  0.02532  0.00971  186 ASP A C   
1231 O O   . ASP A 187 ? 0.35324 0.30457 0.32896 0.00187  0.02409  0.01202  186 ASP A O   
1232 C CB  . ASP A 187 ? 0.36575 0.29158 0.33210 0.00197  0.02543  0.01481  186 ASP A CB  
1233 C CG  . ASP A 187 ? 0.53057 0.43815 0.48845 0.00288  0.02761  0.01643  186 ASP A CG  
1234 O OD1 . ASP A 187 ? 0.55027 0.44085 0.49852 0.00182  0.02941  0.01378  186 ASP A OD1 
1235 O OD2 . ASP A 187 ? 0.56200 0.47091 0.52164 0.00436  0.02763  0.02036  186 ASP A OD2 
1236 N N   . PHE A 188 ? 0.34148 0.27361 0.30225 0.00107  0.02683  0.00643  187 PHE A N   
1237 C CA  . PHE A 188 ? 0.32425 0.26886 0.28788 0.00275  0.02791  0.00590  187 PHE A CA  
1238 C C   . PHE A 188 ? 0.36690 0.31666 0.33065 0.01251  0.03217  0.00661  187 PHE A C   
1239 O O   . PHE A 188 ? 0.35492 0.31387 0.31945 0.01443  0.03449  0.00576  187 PHE A O   
1240 C CB  . PHE A 188 ? 0.37103 0.30890 0.32656 -0.00137 0.02771  0.00216  187 PHE A CB  
1241 C CG  . PHE A 188 ? 0.31291 0.25269 0.27077 -0.01010 0.02294  0.00188  187 PHE A CG  
1242 C CD1 . PHE A 188 ? 0.33829 0.26988 0.29533 -0.01524 0.02008  0.00118  187 PHE A CD1 
1243 C CD2 . PHE A 188 ? 0.32613 0.27606 0.28674 -0.01294 0.02154  0.00254  187 PHE A CD2 
1244 C CE1 . PHE A 188 ? 0.37902 0.31494 0.33927 -0.02207 0.01561  0.00093  187 PHE A CE1 
1245 C CE2 . PHE A 188 ? 0.30281 0.25417 0.26490 -0.01926 0.01699  0.00255  187 PHE A CE2 
1246 C CZ  . PHE A 188 ? 0.32024 0.26573 0.28269 -0.02334 0.01387  0.00159  187 PHE A CZ  
1247 N N   . GLY A 189 ? 0.32760 0.27228 0.29040 0.01906  0.03342  0.00844  188 GLY A N   
1248 C CA  . GLY A 189 ? 0.38568 0.33517 0.34817 0.03011  0.03723  0.00917  188 GLY A CA  
1249 C C   . GLY A 189 ? 0.37490 0.34876 0.34957 0.03241  0.03721  0.01127  188 GLY A C   
1250 O O   . GLY A 189 ? 0.42105 0.40359 0.39708 0.04113  0.04063  0.01135  188 GLY A O   
1251 N N   . SER A 190 ? 0.28990 0.27519 0.27344 0.02494  0.03347  0.01280  189 SER A N   
1252 C CA  . SER A 190 ? 0.30949 0.31688 0.30409 0.02468  0.03318  0.01417  189 SER A CA  
1253 C C   . SER A 190 ? 0.31583 0.32912 0.31184 0.01715  0.03359  0.01288  189 SER A C   
1254 O O   . SER A 190 ? 0.31767 0.34773 0.32247 0.01423  0.03326  0.01405  189 SER A O   
1255 C CB  . SER A 190 ? 0.37362 0.38928 0.37608 0.02188  0.02880  0.01661  189 SER A CB  
1256 O OG  . SER A 190 ? 0.45099 0.46063 0.45074 0.02889  0.02846  0.01849  189 SER A OG  
1257 N N   . GLY A 191 ? 0.30748 0.30700 0.29438 0.01355  0.03412  0.01061  190 GLY A N   
1258 C CA  . GLY A 191 ? 0.31397 0.31646 0.30020 0.00622  0.03371  0.01005  190 GLY A CA  
1259 C C   . GLY A 191 ? 0.36061 0.37308 0.34640 0.00882  0.03876  0.00958  190 GLY A C   
1260 O O   . GLY A 191 ? 0.35044 0.36963 0.33762 0.01695  0.04272  0.00936  190 GLY A O   
1261 N N   . ALA A 192 ? 0.30904 0.32276 0.29242 0.00217  0.03884  0.00969  191 ALA A N   
1262 C CA  . ALA A 192 ? 0.34255 0.36546 0.32428 0.00312  0.04419  0.00965  191 ALA A CA  
1263 C C   . ALA A 192 ? 0.35253 0.36654 0.32456 -0.00314 0.04362  0.00913  191 ALA A C   
1264 O O   . ALA A 192 ? 0.33122 0.33644 0.30114 -0.00880 0.03853  0.00946  191 ALA A O   
1265 C CB  . ALA A 192 ? 0.29613 0.34015 0.29049 0.00065  0.04561  0.01250  191 ALA A CB  
1266 N N   . LEU A 193 ? 0.32659 0.34387 0.29237 -0.00140 0.04900  0.00844  192 LEU A N   
1267 C CA  . LEU A 193 ? 0.31612 0.32900 0.27344 -0.00767 0.04894  0.00926  192 LEU A CA  
1268 C C   . LEU A 193 ? 0.31969 0.34102 0.28526 -0.01575 0.04678  0.01341  192 LEU A C   
1269 O O   . LEU A 193 ? 0.31299 0.34944 0.29001 -0.01660 0.04867  0.01540  192 LEU A O   
1270 C CB  . LEU A 193 ? 0.35294 0.37042 0.30247 -0.00413 0.05620  0.00834  192 LEU A CB  
1271 C CG  . LEU A 193 ? 0.40712 0.41423 0.34629 0.00463  0.05892  0.00351  192 LEU A CG  
1272 C CD1 . LEU A 193 ? 0.46155 0.47592 0.39383 0.00916  0.06702  0.00259  192 LEU A CD1 
1273 C CD2 . LEU A 193 ? 0.41744 0.40428 0.34413 0.00215  0.05364  0.00032  192 LEU A CD2 
1274 N N   . LEU A 194 ? 0.33998 0.35116 0.29954 -0.02156 0.04238  0.01449  193 LEU A N   
1275 C CA  . LEU A 194 ? 0.34049 0.35545 0.30504 -0.02894 0.04036  0.01828  193 LEU A CA  
1276 C C   . LEU A 194 ? 0.35421 0.37762 0.31653 -0.03265 0.04636  0.02118  193 LEU A C   
1277 O O   . LEU A 194 ? 0.33217 0.35208 0.28339 -0.03116 0.05006  0.02079  193 LEU A O   
1278 C CB  . LEU A 194 ? 0.36376 0.36487 0.32124 -0.03237 0.03419  0.01877  193 LEU A CB  
1279 C CG  . LEU A 194 ? 0.40793 0.40735 0.36701 -0.03900 0.03141  0.02248  193 LEU A CG  
1280 C CD1 . LEU A 194 ? 0.37439 0.37991 0.34611 -0.04035 0.02887  0.02263  193 LEU A CD1 
1281 C CD2 . LEU A 194 ? 0.45575 0.44165 0.40532 -0.03979 0.02589  0.02278  193 LEU A CD2 
1282 N N   . LYS A 195 ? 0.33313 0.36806 0.30569 -0.03792 0.04754  0.02394  194 LYS A N   
1283 C CA  . LYS A 195 ? 0.33875 0.38244 0.31061 -0.04375 0.05334  0.02739  194 LYS A CA  
1284 C C   . LYS A 195 ? 0.37320 0.41595 0.35002 -0.05307 0.05033  0.03064  194 LYS A C   
1285 O O   . LYS A 195 ? 0.32950 0.36875 0.31237 -0.05365 0.04448  0.02960  194 LYS A O   
1286 C CB  . LYS A 195 ? 0.39593 0.46037 0.37727 -0.04038 0.06017  0.02677  194 LYS A CB  
1287 C CG  . LYS A 195 ? 0.35785 0.43664 0.35578 -0.04020 0.05789  0.02609  194 LYS A CG  
1288 C CD  . LYS A 195 ? 0.32527 0.42573 0.33280 -0.03406 0.06388  0.02504  194 LYS A CD  
1289 C CE  . LYS A 195 ? 0.36707 0.48243 0.39043 -0.03380 0.06052  0.02455  194 LYS A CE  
1290 N NZ  . LYS A 195 ? 0.38829 0.52717 0.42217 -0.02699 0.06571  0.02381  194 LYS A NZ  
1291 N N   . ASP A 196 ? 0.32836 0.37325 0.30154 -0.06055 0.05471  0.03457  195 ASP A N   
1292 C CA  . ASP A 196 ? 0.37299 0.41427 0.34860 -0.07052 0.05268  0.03782  195 ASP A CA  
1293 C C   . ASP A 196 ? 0.37954 0.44097 0.37027 -0.07660 0.05580  0.03830  195 ASP A C   
1294 O O   . ASP A 196 ? 0.36874 0.42742 0.36276 -0.08552 0.05349  0.03998  195 ASP A O   
1295 C CB  . ASP A 196 ? 0.31985 0.34849 0.28078 -0.07643 0.05537  0.04258  195 ASP A CB  
1296 C CG  . ASP A 196 ? 0.45781 0.46684 0.40388 -0.07122 0.05065  0.04237  195 ASP A CG  
1297 O OD1 . ASP A 196 ? 0.48386 0.48407 0.43155 -0.06829 0.04357  0.04024  195 ASP A OD1 
1298 O OD2 . ASP A 196 ? 0.49842 0.50218 0.43127 -0.06993 0.05400  0.04421  195 ASP A OD2 
1299 N N   . THR A 197 ? 0.36127 0.44285 0.36097 -0.07187 0.06075  0.03664  196 THR A N   
1300 C CA  . THR A 197 ? 0.33066 0.43562 0.34652 -0.07655 0.06325  0.03669  196 THR A CA  
1301 C C   . THR A 197 ? 0.37411 0.48602 0.40153 -0.07104 0.05730  0.03297  196 THR A C   
1302 O O   . THR A 197 ? 0.35134 0.45000 0.37411 -0.06372 0.05230  0.03064  196 THR A O   
1303 C CB  . THR A 197 ? 0.34640 0.47184 0.36614 -0.07324 0.07213  0.03717  196 THR A CB  
1304 O OG1 . THR A 197 ? 0.34187 0.46430 0.35650 -0.05990 0.07283  0.03395  196 THR A OG1 
1305 C CG2 . THR A 197 ? 0.37833 0.49962 0.38746 -0.08107 0.07882  0.04170  196 THR A CG2 
1306 N N   . VAL A 198 ? 0.31779 0.45193 0.36045 -0.07471 0.05791  0.03253  197 VAL A N   
1307 C CA  . VAL A 198 ? 0.29160 0.43197 0.34427 -0.07122 0.05150  0.02957  197 VAL A CA  
1308 C C   . VAL A 198 ? 0.30975 0.45682 0.36481 -0.05680 0.05205  0.02709  197 VAL A C   
1309 O O   . VAL A 198 ? 0.32171 0.47938 0.37706 -0.05057 0.05834  0.02720  197 VAL A O   
1310 C CB  . VAL A 198 ? 0.31125 0.47395 0.37893 -0.08051 0.05117  0.02967  197 VAL A CB  
1311 C CG1 . VAL A 198 ? 0.35510 0.54745 0.43463 -0.07725 0.05790  0.03001  197 VAL A CG1 
1312 C CG2 . VAL A 198 ? 0.29742 0.46158 0.37196 -0.07902 0.04309  0.02669  197 VAL A CG2 
1313 N N   . TYR A 199 ? 0.26048 0.39950 0.31581 -0.05114 0.04572  0.02492  198 TYR A N   
1314 C CA  . TYR A 199 ? 0.28580 0.43090 0.34431 -0.03833 0.04535  0.02293  198 TYR A CA  
1315 C C   . TYR A 199 ? 0.30916 0.47716 0.38260 -0.03780 0.04277  0.02221  198 TYR A C   
1316 O O   . TYR A 199 ? 0.29568 0.46448 0.37348 -0.04559 0.03760  0.02186  198 TYR A O   
1317 C CB  . TYR A 199 ? 0.26985 0.39271 0.31921 -0.03280 0.04029  0.02150  198 TYR A CB  
1318 C CG  . TYR A 199 ? 0.30626 0.40833 0.34140 -0.03166 0.04184  0.02151  198 TYR A CG  
1319 C CD1 . TYR A 199 ? 0.30720 0.39408 0.33460 -0.03974 0.03966  0.02274  198 TYR A CD1 
1320 C CD2 . TYR A 199 ? 0.28213 0.37912 0.31077 -0.02211 0.04508  0.02008  198 TYR A CD2 
1321 C CE1 . TYR A 199 ? 0.25361 0.32334 0.26816 -0.03826 0.04021  0.02267  198 TYR A CE1 
1322 C CE2 . TYR A 199 ? 0.26376 0.34254 0.27917 -0.02164 0.04571  0.01945  198 TYR A CE2 
1323 C CZ  . TYR A 199 ? 0.30647 0.37291 0.31534 -0.02971 0.04306  0.02081  198 TYR A CZ  
1324 O OH  . TYR A 199 ? 0.32156 0.37188 0.31739 -0.02888 0.04301  0.02013  198 TYR A OH  
1325 N N   . THR A 200 ? 0.34479 0.53131 0.42540 -0.02804 0.04610  0.02176  199 THR A N   
1326 C CA  . THR A 200 ? 0.28375 0.49400 0.37846 -0.02527 0.04310  0.02111  199 THR A CA  
1327 C C   . THR A 200 ? 0.36513 0.57404 0.45858 -0.00996 0.04133  0.02020  199 THR A C   
1328 O O   . THR A 200 ? 0.33879 0.56814 0.44289 -0.00475 0.03899  0.01998  199 THR A O   
1329 C CB  . THR A 200 ? 0.33947 0.58010 0.44729 -0.02812 0.04853  0.02198  199 THR A CB  
1330 O OG1 . THR A 200 ? 0.28766 0.53078 0.39148 -0.01840 0.05608  0.02230  199 THR A OG1 
1331 C CG2 . THR A 200 ? 0.34734 0.58913 0.45670 -0.04519 0.04997  0.02338  199 THR A CG2 
1332 N N   . ASP A 201 ? 0.34466 0.52990 0.42491 -0.00288 0.04226  0.01978  200 ASP A N   
1333 C CA  . ASP A 201 ? 0.38894 0.56609 0.46483 0.01022  0.04050  0.01928  200 ASP A CA  
1334 C C   . ASP A 201 ? 0.33178 0.48385 0.39807 0.00737  0.03525  0.01897  200 ASP A C   
1335 O O   . ASP A 201 ? 0.33694 0.47402 0.39668 -0.00130 0.03472  0.01880  200 ASP A O   
1336 C CB  . ASP A 201 ? 0.40709 0.57700 0.47479 0.02118  0.04683  0.01865  200 ASP A CB  
1337 C CG  . ASP A 201 ? 0.60070 0.74596 0.65436 0.01659  0.04888  0.01780  200 ASP A CG  
1338 O OD1 . ASP A 201 ? 0.60493 0.75135 0.65822 0.00635  0.05064  0.01836  200 ASP A OD1 
1339 O OD2 . ASP A 201 ? 0.59509 0.71945 0.63754 0.02297  0.04854  0.01667  200 ASP A OD2 
1340 N N   . PHE A 202 ? 0.32866 0.47679 0.39389 0.01507  0.03155  0.01919  201 PHE A N   
1341 C CA  . PHE A 202 ? 0.32632 0.45252 0.38296 0.01290  0.02732  0.01909  201 PHE A CA  
1342 C C   . PHE A 202 ? 0.34545 0.46566 0.39825 0.02422  0.02588  0.02000  201 PHE A C   
1343 O O   . PHE A 202 ? 0.37163 0.50808 0.43140 0.03019  0.02396  0.02093  201 PHE A O   
1344 C CB  . PHE A 202 ? 0.27442 0.40375 0.33556 0.00253  0.02192  0.01882  201 PHE A CB  
1345 C CG  . PHE A 202 ? 0.29251 0.40214 0.34574 0.00108  0.01801  0.01868  201 PHE A CG  
1346 C CD1 . PHE A 202 ? 0.29499 0.38554 0.33973 -0.00344 0.01874  0.01822  201 PHE A CD1 
1347 C CD2 . PHE A 202 ? 0.28776 0.39950 0.34208 0.00445  0.01365  0.01907  201 PHE A CD2 
1348 C CE1 . PHE A 202 ? 0.26446 0.33988 0.30343 -0.00467 0.01544  0.01809  201 PHE A CE1 
1349 C CE2 . PHE A 202 ? 0.30779 0.40309 0.35512 0.00308  0.01084  0.01908  201 PHE A CE2 
1350 C CZ  . PHE A 202 ? 0.27891 0.35688 0.31933 -0.00153 0.01191  0.01855  201 PHE A CZ  
1351 N N   A ASP A 203 ? 0.32151 0.41834 0.36288 0.02657  0.02658  0.01989  202 ASP A N   
1352 N N   B ASP A 203 ? 0.32134 0.41828 0.36269 0.02689  0.02667  0.01990  202 ASP A N   
1353 C CA  A ASP A 203 ? 0.37581 0.46154 0.41072 0.03624  0.02603  0.02122  202 ASP A CA  
1354 C CA  B ASP A 203 ? 0.37438 0.46113 0.40983 0.03628  0.02569  0.02133  202 ASP A CA  
1355 C C   A ASP A 203 ? 0.37077 0.43773 0.39865 0.03142  0.02288  0.02161  202 ASP A C   
1356 C C   B ASP A 203 ? 0.37084 0.43723 0.39845 0.03135  0.02301  0.02156  202 ASP A C   
1357 O O   A ASP A 203 ? 0.37635 0.43005 0.39692 0.03757  0.02302  0.02304  202 ASP A O   
1358 O O   B ASP A 203 ? 0.37708 0.42850 0.39659 0.03721  0.02360  0.02274  202 ASP A O   
1359 C CB  A ASP A 203 ? 0.42731 0.50196 0.45400 0.04512  0.03136  0.02058  202 ASP A CB  
1360 C CB  B ASP A 203 ? 0.41997 0.49833 0.44831 0.04700  0.03078  0.02111  202 ASP A CB  
1361 C CG  A ASP A 203 ? 0.47898 0.54506 0.49964 0.05713  0.03155  0.02248  202 ASP A CG  
1362 C CG  B ASP A 203 ? 0.42711 0.52784 0.46370 0.05460  0.03383  0.02115  202 ASP A CG  
1363 O OD1 A ASP A 203 ? 0.50509 0.58121 0.53039 0.06067  0.02799  0.02471  202 ASP A OD1 
1364 O OD1 B ASP A 203 ? 0.49323 0.61360 0.53913 0.05814  0.03101  0.02260  202 ASP A OD1 
1365 O OD2 A ASP A 203 ? 0.58179 0.62976 0.59181 0.06299  0.03516  0.02173  202 ASP A OD2 
1366 O OD2 B ASP A 203 ? 0.54743 0.64737 0.58125 0.05716  0.03902  0.01958  202 ASP A OD2 
1367 N N   . GLY A 204 ? 0.32688 0.39225 0.35646 0.02085  0.02037  0.02060  203 GLY A N   
1368 C CA  . GLY A 204 ? 0.26842 0.31895 0.29264 0.01648  0.01774  0.02078  203 GLY A CA  
1369 C C   . GLY A 204 ? 0.29684 0.35325 0.32353 0.01819  0.01386  0.02225  203 GLY A C   
1370 O O   . GLY A 204 ? 0.31710 0.38534 0.34724 0.02502  0.01316  0.02354  203 GLY A O   
1371 N N   . THR A 205 ? 0.25987 0.30889 0.28448 0.01243  0.01120  0.02197  204 THR A N   
1372 C CA  . THR A 205 ? 0.24547 0.29734 0.26988 0.01405  0.00790  0.02317  204 THR A CA  
1373 C C   . THR A 205 ? 0.26854 0.33538 0.30005 0.00910  0.00403  0.02146  204 THR A C   
1374 O O   . THR A 205 ? 0.26135 0.32635 0.29426 0.00122  0.00296  0.01949  204 THR A O   
1375 C CB  . THR A 205 ? 0.25233 0.28935 0.27058 0.01093  0.00769  0.02359  204 THR A CB  
1376 O OG1 . THR A 205 ? 0.30488 0.32766 0.31650 0.01409  0.01117  0.02489  204 THR A OG1 
1377 C CG2 . THR A 205 ? 0.23375 0.27332 0.25020 0.01324  0.00506  0.02505  204 THR A CG2 
1378 N N   . ARG A 206 ? 0.24161 0.32244 0.27676 0.01375  0.00160  0.02215  205 ARG A N   
1379 C CA  . ARG A 206 ? 0.23783 0.33453 0.28033 0.00823  -0.00223 0.01991  205 ARG A CA  
1380 C C   . ARG A 206 ? 0.23519 0.32528 0.27474 0.00133  -0.00558 0.01787  205 ARG A C   
1381 O O   . ARG A 206 ? 0.25312 0.34724 0.29634 -0.00669 -0.00743 0.01531  205 ARG A O   
1382 C CB  . ARG A 206 ? 0.26335 0.37782 0.31021 0.01504  -0.00496 0.02085  205 ARG A CB  
1383 C CG  . ARG A 206 ? 0.27393 0.40740 0.32965 0.00834  -0.00912 0.01804  205 ARG A CG  
1384 C CD  . ARG A 206 ? 0.31043 0.46474 0.37160 0.01591  -0.01217 0.01897  205 ARG A CD  
1385 N NE  . ARG A 206 ? 0.31697 0.49212 0.38810 0.00847  -0.01621 0.01595  205 ARG A NE  
1386 C CZ  . ARG A 206 ? 0.33716 0.52927 0.41890 0.00528  -0.01443 0.01528  205 ARG A CZ  
1387 N NH1 . ARG A 206 ? 0.31461 0.50436 0.39763 0.00895  -0.00843 0.01706  205 ARG A NH1 
1388 N NH2 . ARG A 206 ? 0.28749 0.49973 0.37848 -0.00219 -0.01862 0.01255  205 ARG A NH2 
1389 N N   . VAL A 207 ? 0.22510 0.30437 0.25745 0.00426  -0.00599 0.01899  206 VAL A N   
1390 C CA  . VAL A 207 ? 0.22777 0.30159 0.25694 -0.00092 -0.00872 0.01676  206 VAL A CA  
1391 C C   . VAL A 207 ? 0.25399 0.31611 0.28199 -0.00727 -0.00717 0.01536  206 VAL A C   
1392 O O   . VAL A 207 ? 0.25165 0.30925 0.27736 -0.01135 -0.00935 0.01311  206 VAL A O   
1393 C CB  . VAL A 207 ? 0.26363 0.33111 0.28541 0.00397  -0.00907 0.01844  206 VAL A CB  
1394 C CG1 . VAL A 207 ? 0.26258 0.34234 0.28390 0.00976  -0.01226 0.01936  206 VAL A CG1 
1395 C CG2 . VAL A 207 ? 0.25033 0.30500 0.26734 0.00771  -0.00455 0.02177  206 VAL A CG2 
1396 N N   . TYR A 208 ? 0.24434 0.30127 0.27302 -0.00763 -0.00370 0.01646  207 TYR A N   
1397 C CA  . TYR A 208 ? 0.23227 0.28049 0.26003 -0.01348 -0.00286 0.01527  207 TYR A CA  
1398 C C   . TYR A 208 ? 0.24056 0.29504 0.27279 -0.01842 -0.00236 0.01442  207 TYR A C   
1399 O O   . TYR A 208 ? 0.22226 0.26920 0.25265 -0.02293 -0.00149 0.01403  207 TYR A O   
1400 C CB  . TYR A 208 ? 0.23315 0.27033 0.25711 -0.01158 0.00038  0.01674  207 TYR A CB  
1401 C CG  . TYR A 208 ? 0.24731 0.27639 0.26701 -0.00989 0.00042  0.01746  207 TYR A CG  
1402 C CD1 . TYR A 208 ? 0.22109 0.25059 0.23838 -0.00470 0.00112  0.01947  207 TYR A CD1 
1403 C CD2 . TYR A 208 ? 0.22371 0.24536 0.24169 -0.01325 0.00007  0.01651  207 TYR A CD2 
1404 C CE1 . TYR A 208 ? 0.25372 0.27649 0.26714 -0.00403 0.00202  0.02059  207 TYR A CE1 
1405 C CE2 . TYR A 208 ? 0.22829 0.24534 0.24381 -0.01208 0.00064  0.01722  207 TYR A CE2 
1406 C CZ  . TYR A 208 ? 0.22269 0.24034 0.23602 -0.00804 0.00192  0.01930  207 TYR A CZ  
1407 O OH  . TYR A 208 ? 0.25294 0.26669 0.26391 -0.00782 0.00327  0.02040  207 TYR A OH  
1408 N N   . SER A 209 ? 0.27122 0.34044 0.30933 -0.01741 -0.00267 0.01448  208 SER A N   
1409 C CA  . SER A 209 ? 0.22359 0.30128 0.26693 -0.02244 -0.00121 0.01412  208 SER A CA  
1410 C C   . SER A 209 ? 0.23791 0.31833 0.28318 -0.03108 -0.00458 0.01184  208 SER A C   
1411 O O   . SER A 209 ? 0.25815 0.33903 0.30221 -0.03143 -0.00851 0.01009  208 SER A O   
1412 C CB  . SER A 209 ? 0.24733 0.34192 0.29727 -0.01719 0.00032  0.01516  208 SER A CB  
1413 O OG  . SER A 209 ? 0.27441 0.38285 0.32904 -0.01644 -0.00371 0.01421  208 SER A OG  
1414 N N   . PRO A 210 ? 0.24144 0.32237 0.28844 -0.03830 -0.00292 0.01181  209 PRO A N   
1415 C CA  . PRO A 210 ? 0.25659 0.33371 0.30262 -0.04754 -0.00570 0.00982  209 PRO A CA  
1416 C C   . PRO A 210 ? 0.27933 0.37451 0.33352 -0.05251 -0.00803 0.00813  209 PRO A C   
1417 O O   . PRO A 210 ? 0.25260 0.36577 0.31463 -0.04899 -0.00671 0.00906  209 PRO A O   
1418 C CB  . PRO A 210 ? 0.23295 0.30129 0.27588 -0.05283 -0.00219 0.01148  209 PRO A CB  
1419 C CG  . PRO A 210 ? 0.26181 0.34149 0.30939 -0.04877 0.00237  0.01352  209 PRO A CG  
1420 C CD  . PRO A 210 ? 0.24643 0.32762 0.29383 -0.03837 0.00200  0.01374  209 PRO A CD  
1421 N N   . PRO A 211 ? 0.23119 0.32232 0.28366 -0.06077 -0.01164 0.00540  210 PRO A N   
1422 C CA  . PRO A 211 ? 0.24335 0.35257 0.30369 -0.06659 -0.01492 0.00300  210 PRO A CA  
1423 C C   . PRO A 211 ? 0.26969 0.39561 0.33959 -0.07269 -0.01151 0.00451  210 PRO A C   
1424 O O   . PRO A 211 ? 0.26333 0.41181 0.34316 -0.07372 -0.01330 0.00346  210 PRO A O   
1425 C CB  . PRO A 211 ? 0.29789 0.39316 0.35146 -0.07513 -0.01902 -0.00061 210 PRO A CB  
1426 C CG  . PRO A 211 ? 0.31355 0.38485 0.35715 -0.07485 -0.01655 0.00092  210 PRO A CG  
1427 C CD  . PRO A 211 ? 0.29304 0.36279 0.33574 -0.06412 -0.01341 0.00395  210 PRO A CD  
1428 N N   . GLU A 212 ? 0.25823 0.37513 0.32544 -0.07660 -0.00663 0.00702  211 GLU A N   
1429 C CA  . GLU A 212 ? 0.26457 0.39855 0.34061 -0.08203 -0.00229 0.00882  211 GLU A CA  
1430 C C   . GLU A 212 ? 0.26546 0.41852 0.34930 -0.07138 0.00062  0.01047  211 GLU A C   
1431 O O   . GLU A 212 ? 0.27879 0.45496 0.37363 -0.07374 0.00265  0.01089  211 GLU A O   
1432 C CB  . GLU A 212 ? 0.28464 0.40315 0.35373 -0.08777 0.00262  0.01160  211 GLU A CB  
1433 C CG  . GLU A 212 ? 0.27676 0.37937 0.33697 -0.07842 0.00559  0.01389  211 GLU A CG  
1434 C CD  . GLU A 212 ? 0.30079 0.37904 0.34963 -0.07668 0.00216  0.01299  211 GLU A CD  
1435 O OE1 . GLU A 212 ? 0.28255 0.35666 0.33011 -0.07886 -0.00273 0.01013  211 GLU A OE1 
1436 O OE2 . GLU A 212 ? 0.28997 0.35414 0.33107 -0.07277 0.00433  0.01491  211 GLU A OE2 
1437 N N   . TRP A 213 ? 0.27459 0.41843 0.35284 -0.05965 0.00110  0.01142  212 TRP A N   
1438 C CA  . TRP A 213 ? 0.24278 0.40176 0.32662 -0.04849 0.00331  0.01272  212 TRP A CA  
1439 C C   . TRP A 213 ? 0.27913 0.45719 0.37070 -0.04511 -0.00169 0.01111  212 TRP A C   
1440 O O   . TRP A 213 ? 0.28528 0.48688 0.38712 -0.04154 -0.00057 0.01164  212 TRP A O   
1441 C CB  . TRP A 213 ? 0.23985 0.38129 0.31437 -0.03812 0.00503  0.01409  212 TRP A CB  
1442 C CG  . TRP A 213 ? 0.27713 0.42992 0.35500 -0.02575 0.00608  0.01515  212 TRP A CG  
1443 C CD1 . TRP A 213 ? 0.28917 0.43962 0.36430 -0.01740 0.00281  0.01527  212 TRP A CD1 
1444 C CD2 . TRP A 213 ? 0.25797 0.42602 0.34183 -0.01989 0.01090  0.01643  212 TRP A CD2 
1445 N NE1 . TRP A 213 ? 0.26504 0.42643 0.34330 -0.00647 0.00507  0.01682  212 TRP A NE1 
1446 C CE2 . TRP A 213 ? 0.26052 0.43317 0.34442 -0.00735 0.01001  0.01727  212 TRP A CE2 
1447 C CE3 . TRP A 213 ? 0.29204 0.46984 0.38034 -0.02355 0.01633  0.01713  212 TRP A CE3 
1448 C CZ2 . TRP A 213 ? 0.28283 0.46896 0.37113 0.00246  0.01406  0.01845  212 TRP A CZ2 
1449 C CZ3 . TRP A 213 ? 0.31435 0.50730 0.40766 -0.01407 0.02072  0.01807  212 TRP A CZ3 
1450 C CH2 . TRP A 213 ? 0.28201 0.47872 0.37533 -0.00083 0.01941  0.01855  212 TRP A CH2 
1451 N N   . ILE A 214 ? 0.25569 0.42482 0.34212 -0.04554 -0.00729 0.00909  213 ILE A N   
1452 C CA  . ILE A 214 ? 0.24996 0.43628 0.34178 -0.04253 -0.01285 0.00737  213 ILE A CA  
1453 C C   . ILE A 214 ? 0.23667 0.44711 0.34070 -0.05211 -0.01462 0.00550  213 ILE A C   
1454 O O   . ILE A 214 ? 0.26004 0.49556 0.37409 -0.04727 -0.01611 0.00563  213 ILE A O   
1455 C CB  . ILE A 214 ? 0.22669 0.39782 0.30927 -0.04333 -0.01820 0.00498  213 ILE A CB  
1456 C CG1 . ILE A 214 ? 0.28613 0.43528 0.35784 -0.03503 -0.01597 0.00700  213 ILE A CG1 
1457 C CG2 . ILE A 214 ? 0.29001 0.47908 0.37657 -0.04025 -0.02444 0.00303  213 ILE A CG2 
1458 C CD1 . ILE A 214 ? 0.22409 0.37751 0.29527 -0.02176 -0.01439 0.00997  213 ILE A CD1 
1459 N N   . ARG A 215 ? 0.25562 0.45907 0.35900 -0.06598 -0.01446 0.00388  214 ARG A N   
1460 C CA  . ARG A 215 ? 0.29231 0.51697 0.40670 -0.07788 -0.01664 0.00165  214 ARG A CA  
1461 C C   . ARG A 215 ? 0.30695 0.55364 0.43336 -0.07899 -0.01064 0.00423  214 ARG A C   
1462 O O   . ARG A 215 ? 0.28435 0.56063 0.42426 -0.08071 -0.01237 0.00327  214 ARG A O   
1463 C CB  . ARG A 215 ? 0.32984 0.53637 0.43773 -0.09292 -0.01813 -0.00075 214 ARG A CB  
1464 C CG  . ARG A 215 ? 0.37269 0.56450 0.47137 -0.09474 -0.02510 -0.00494 214 ARG A CG  
1465 C CD  . ARG A 215 ? 0.43457 0.61177 0.52844 -0.11075 -0.02631 -0.00763 214 ARG A CD  
1466 N NE  . ARG A 215 ? 0.60222 0.76310 0.68570 -0.11263 -0.03258 -0.01232 214 ARG A NE  
1467 C CZ  . ARG A 215 ? 0.61831 0.79056 0.70461 -0.11932 -0.03917 -0.01732 214 ARG A CZ  
1468 N NH1 . ARG A 215 ? 0.63505 0.83690 0.73565 -0.12539 -0.04086 -0.01821 214 ARG A NH1 
1469 N NH2 . ARG A 215 ? 0.56112 0.71562 0.63558 -0.11973 -0.04428 -0.02182 214 ARG A NH2 
1470 N N   . TYR A 216 ? 0.30269 0.53664 0.42438 -0.07817 -0.00360 0.00733  215 TYR A N   
1471 C CA  . TYR A 216 ? 0.33375 0.58525 0.46467 -0.08232 0.00303  0.00957  215 TYR A CA  
1472 C C   . TYR A 216 ? 0.27316 0.52707 0.40343 -0.06877 0.00945  0.01260  215 TYR A C   
1473 O O   . TYR A 216 ? 0.27602 0.54562 0.41343 -0.07052 0.01569  0.01438  215 TYR A O   
1474 C CB  . TYR A 216 ? 0.31425 0.54918 0.43921 -0.09673 0.00651  0.01055  215 TYR A CB  
1475 C CG  . TYR A 216 ? 0.37800 0.60178 0.49931 -0.11023 0.00074  0.00743  215 TYR A CG  
1476 C CD1 . TYR A 216 ? 0.42388 0.66990 0.55659 -0.12011 -0.00353 0.00443  215 TYR A CD1 
1477 C CD2 . TYR A 216 ? 0.38757 0.57860 0.49371 -0.11294 -0.00055 0.00719  215 TYR A CD2 
1478 C CE1 . TYR A 216 ? 0.45069 0.68400 0.57838 -0.13290 -0.00893 0.00085  215 TYR A CE1 
1479 C CE2 . TYR A 216 ? 0.43626 0.61458 0.53738 -0.12427 -0.00553 0.00399  215 TYR A CE2 
1480 C CZ  . TYR A 216 ? 0.51619 0.71438 0.62741 -0.13452 -0.00967 0.00064  215 TYR A CZ  
1481 O OH  . TYR A 216 ? 0.64588 0.82874 0.75035 -0.14610 -0.01475 -0.00322 215 TYR A OH  
1482 N N   . HIS A 217 ? 0.28887 0.52707 0.41014 -0.05592 0.00850  0.01310  216 HIS A N   
1483 C CA  . HIS A 217 ? 0.30583 0.54010 0.42331 -0.04370 0.01441  0.01540  216 HIS A CA  
1484 C C   . HIS A 217 ? 0.31340 0.53622 0.42522 -0.04958 0.02113  0.01715  216 HIS A C   
1485 O O   . HIS A 217 ? 0.27828 0.51054 0.39241 -0.04437 0.02752  0.01862  216 HIS A O   
1486 C CB  . HIS A 217 ? 0.34697 0.61013 0.47628 -0.03344 0.01616  0.01596  216 HIS A CB  
1487 C CG  . HIS A 217 ? 0.42935 0.69474 0.55789 -0.02114 0.01096  0.01559  216 HIS A CG  
1488 N ND1 . HIS A 217 ? 0.47669 0.76238 0.61231 -0.00785 0.01194  0.01659  216 HIS A ND1 
1489 C CD2 . HIS A 217 ? 0.44922 0.69853 0.56974 -0.01962 0.00502  0.01469  216 HIS A CD2 
1490 C CE1 . HIS A 217 ? 0.57894 0.85980 0.71022 0.00105  0.00659  0.01668  216 HIS A CE1 
1491 N NE2 . HIS A 217 ? 0.48265 0.74204 0.60488 -0.00623 0.00254  0.01552  216 HIS A NE2 
1492 N N   . ARG A 218 ? 0.29816 0.49990 0.40139 -0.05980 0.01967  0.01701  217 ARG A N   
1493 C CA  . ARG A 218 ? 0.28934 0.47666 0.38455 -0.06577 0.02497  0.01906  217 ARG A CA  
1494 C C   . ARG A 218 ? 0.29901 0.45605 0.38044 -0.06741 0.02168  0.01882  217 ARG A C   
1495 O O   . ARG A 218 ? 0.30716 0.45680 0.38725 -0.07163 0.01589  0.01697  217 ARG A O   
1496 C CB  . ARG A 218 ? 0.26312 0.46175 0.36455 -0.08054 0.02745  0.01998  217 ARG A CB  
1497 C CG  . ARG A 218 ? 0.29987 0.53184 0.41652 -0.08090 0.03168  0.02049  217 ARG A CG  
1498 C CD  . ARG A 218 ? 0.33759 0.58054 0.46129 -0.09824 0.03260  0.02094  217 ARG A CD  
1499 N NE  . ARG A 218 ? 0.34425 0.56792 0.45702 -0.10713 0.03759  0.02391  217 ARG A NE  
1500 C CZ  . ARG A 218 ? 0.37111 0.60210 0.48361 -0.10741 0.04596  0.02694  217 ARG A CZ  
1501 N NH1 . ARG A 218 ? 0.32648 0.58328 0.44918 -0.09868 0.05070  0.02707  217 ARG A NH1 
1502 N NH2 . ARG A 218 ? 0.32968 0.54117 0.43036 -0.11575 0.04980  0.03000  217 ARG A NH2 
1503 N N   . TYR A 219 ? 0.27834 0.41879 0.34941 -0.06384 0.02527  0.02043  218 TYR A N   
1504 C CA  . TYR A 219 ? 0.25254 0.36670 0.31134 -0.06573 0.02244  0.02053  218 TYR A CA  
1505 C C   . TYR A 219 ? 0.26974 0.37205 0.31889 -0.06569 0.02739  0.02285  218 TYR A C   
1506 O O   . TYR A 219 ? 0.28439 0.39658 0.33495 -0.06172 0.03286  0.02378  218 TYR A O   
1507 C CB  . TYR A 219 ? 0.23330 0.33736 0.28839 -0.05642 0.01809  0.01885  218 TYR A CB  
1508 C CG  . TYR A 219 ? 0.26910 0.37539 0.32314 -0.04503 0.02111  0.01908  218 TYR A CG  
1509 C CD1 . TYR A 219 ? 0.26931 0.39420 0.33200 -0.03808 0.02208  0.01866  218 TYR A CD1 
1510 C CD2 . TYR A 219 ? 0.28105 0.37039 0.32484 -0.04107 0.02274  0.01954  218 TYR A CD2 
1511 C CE1 . TYR A 219 ? 0.28358 0.40752 0.34360 -0.02719 0.02506  0.01880  218 TYR A CE1 
1512 C CE2 . TYR A 219 ? 0.24944 0.33846 0.29090 -0.03157 0.02554  0.01922  218 TYR A CE2 
1513 C CZ  . TYR A 219 ? 0.28136 0.38632 0.33036 -0.02448 0.02692  0.01889  218 TYR A CZ  
1514 O OH  . TYR A 219 ? 0.29034 0.39172 0.33523 -0.01442 0.02982  0.01848  218 TYR A OH  
1515 N N   . HIS A 220 ? 0.28717 0.36832 0.32578 -0.06942 0.02527  0.02365  219 HIS A N   
1516 C CA  . HIS A 220 ? 0.29818 0.36563 0.32552 -0.06810 0.02834  0.02567  219 HIS A CA  
1517 C C   . HIS A 220 ? 0.31523 0.36777 0.33557 -0.06010 0.02469  0.02422  219 HIS A C   
1518 O O   . HIS A 220 ? 0.26352 0.31203 0.28576 -0.05820 0.01981  0.02244  219 HIS A O   
1519 C CB  . HIS A 220 ? 0.30495 0.36045 0.32489 -0.07820 0.02897  0.02841  219 HIS A CB  
1520 C CG  . HIS A 220 ? 0.31409 0.38421 0.33969 -0.08692 0.03429  0.03052  219 HIS A CG  
1521 N ND1 . HIS A 220 ? 0.30217 0.38657 0.33890 -0.09431 0.03316  0.02946  219 HIS A ND1 
1522 C CD2 . HIS A 220 ? 0.33383 0.40877 0.35615 -0.08941 0.04104  0.03346  219 HIS A CD2 
1523 C CE1 . HIS A 220 ? 0.30783 0.40573 0.34887 -0.10182 0.03903  0.03183  219 HIS A CE1 
1524 N NE2 . HIS A 220 ? 0.35837 0.45074 0.39058 -0.09872 0.04427  0.03447  219 HIS A NE2 
1525 N N   . GLY A 221 ? 0.29458 0.34016 0.30688 -0.05561 0.02728  0.02479  220 GLY A N   
1526 C CA  . GLY A 221 ? 0.29429 0.33072 0.30245 -0.04793 0.02461  0.02288  220 GLY A CA  
1527 C C   . GLY A 221 ? 0.30721 0.32903 0.31064 -0.04895 0.01906  0.02261  220 GLY A C   
1528 O O   . GLY A 221 ? 0.27494 0.29530 0.28125 -0.04503 0.01567  0.02083  220 GLY A O   
1529 N N   . ARG A 222 ? 0.29094 0.30177 0.28644 -0.05355 0.01835  0.02464  221 ARG A N   
1530 C CA  . ARG A 222 ? 0.31083 0.30807 0.30110 -0.05263 0.01327  0.02442  221 ARG A CA  
1531 C C   . ARG A 222 ? 0.29076 0.28803 0.28647 -0.05465 0.00972  0.02320  221 ARG A C   
1532 O O   . ARG A 222 ? 0.27777 0.27081 0.27401 -0.05069 0.00601  0.02153  221 ARG A O   
1533 C CB  . ARG A 222 ? 0.36621 0.35108 0.34540 -0.05576 0.01328  0.02734  221 ARG A CB  
1534 C CG  . ARG A 222 ? 0.48623 0.46967 0.45768 -0.05307 0.01595  0.02807  221 ARG A CG  
1535 C CD  . ARG A 222 ? 0.58522 0.55870 0.54515 -0.05700 0.01719  0.03193  221 ARG A CD  
1536 N NE  . ARG A 222 ? 0.64055 0.61415 0.59218 -0.05488 0.02036  0.03251  221 ARG A NE  
1537 C CZ  . ARG A 222 ? 0.63386 0.61531 0.58472 -0.05721 0.02664  0.03373  221 ARG A CZ  
1538 N NH1 . ARG A 222 ? 0.64539 0.63753 0.60501 -0.06212 0.03041  0.03461  221 ARG A NH1 
1539 N NH2 . ARG A 222 ? 0.77975 0.75928 0.72069 -0.05463 0.02920  0.03391  221 ARG A NH2 
1540 N N   . SER A 223 ? 0.28002 0.28244 0.27959 -0.06119 0.01085  0.02378  222 SER A N   
1541 C CA  . SER A 223 ? 0.26596 0.26701 0.26901 -0.06345 0.00701  0.02187  222 SER A CA  
1542 C C   . SER A 223 ? 0.25429 0.26728 0.26600 -0.05846 0.00559  0.01919  222 SER A C   
1543 O O   . SER A 223 ? 0.25936 0.26875 0.27148 -0.05675 0.00182  0.01721  222 SER A O   
1544 C CB  . SER A 223 ? 0.31291 0.31558 0.31728 -0.07322 0.00811  0.02272  222 SER A CB  
1545 O OG  . SER A 223 ? 0.30060 0.32079 0.31285 -0.07613 0.01234  0.02337  222 SER A OG  
1546 N N   . ALA A 224 ? 0.24668 0.27298 0.26413 -0.05523 0.00871  0.01925  223 ALA A N   
1547 C CA  . ALA A 224 ? 0.24380 0.27881 0.26726 -0.04904 0.00740  0.01748  223 ALA A CA  
1548 C C   . ALA A 224 ? 0.27796 0.30304 0.29683 -0.04280 0.00574  0.01694  223 ALA A C   
1549 O O   . ALA A 224 ? 0.22662 0.25237 0.24745 -0.03940 0.00324  0.01568  223 ALA A O   
1550 C CB  . ALA A 224 ? 0.24774 0.29784 0.27725 -0.04573 0.01133  0.01792  223 ALA A CB  
1551 N N   . ALA A 225 ? 0.25523 0.27181 0.26779 -0.04169 0.00711  0.01789  224 ALA A N   
1552 C CA  . ALA A 225 ? 0.26636 0.27483 0.27535 -0.03733 0.00525  0.01719  224 ALA A CA  
1553 C C   . ALA A 225 ? 0.24950 0.25117 0.25714 -0.03797 0.00124  0.01651  224 ALA A C   
1554 O O   . ALA A 225 ? 0.23954 0.24085 0.24860 -0.03439 -0.00038 0.01550  224 ALA A O   
1555 C CB  . ALA A 225 ? 0.28847 0.28996 0.29050 -0.03698 0.00662  0.01790  224 ALA A CB  
1556 N N   . VAL A 226 ? 0.23590 0.23152 0.24011 -0.04234 0.00001  0.01716  225 VAL A N   
1557 C CA  . VAL A 226 ? 0.25205 0.23944 0.25351 -0.04183 -0.00358 0.01622  225 VAL A CA  
1558 C C   . VAL A 226 ? 0.23271 0.22571 0.23898 -0.04112 -0.00518 0.01404  225 VAL A C   
1559 O O   . VAL A 226 ? 0.23231 0.22244 0.23787 -0.03750 -0.00732 0.01268  225 VAL A O   
1560 C CB  . VAL A 226 ? 0.27012 0.24686 0.26494 -0.04650 -0.00425 0.01762  225 VAL A CB  
1561 C CG1 . VAL A 226 ? 0.24957 0.21699 0.24108 -0.04566 -0.00775 0.01603  225 VAL A CG1 
1562 C CG2 . VAL A 226 ? 0.28105 0.25075 0.26897 -0.04524 -0.00371 0.01992  225 VAL A CG2 
1563 N N   . TRP A 227 ? 0.23054 0.23300 0.24173 -0.04425 -0.00419 0.01362  226 TRP A N   
1564 C CA  . TRP A 227 ? 0.25578 0.26527 0.27100 -0.04292 -0.00616 0.01150  226 TRP A CA  
1565 C C   . TRP A 227 ? 0.25526 0.26805 0.27203 -0.03604 -0.00584 0.01154  226 TRP A C   
1566 O O   . TRP A 227 ? 0.23639 0.24768 0.25209 -0.03331 -0.00779 0.01015  226 TRP A O   
1567 C CB  . TRP A 227 ? 0.23075 0.25348 0.25229 -0.04676 -0.00539 0.01123  226 TRP A CB  
1568 C CG  . TRP A 227 ? 0.27146 0.30259 0.29643 -0.04466 -0.00804 0.00912  226 TRP A CG  
1569 C CD1 . TRP A 227 ? 0.26339 0.30216 0.29104 -0.03801 -0.00772 0.00955  226 TRP A CD1 
1570 C CD2 . TRP A 227 ? 0.22987 0.26115 0.25423 -0.04909 -0.01162 0.00622  226 TRP A CD2 
1571 N NE1 . TRP A 227 ? 0.21814 0.26299 0.24687 -0.03755 -0.01094 0.00747  226 TRP A NE1 
1572 C CE2 . TRP A 227 ? 0.24446 0.28532 0.27137 -0.04444 -0.01356 0.00498  226 TRP A CE2 
1573 C CE3 . TRP A 227 ? 0.28710 0.30982 0.30774 -0.05669 -0.01344 0.00450  226 TRP A CE3 
1574 C CZ2 . TRP A 227 ? 0.24930 0.29300 0.27534 -0.04705 -0.01760 0.00160  226 TRP A CZ2 
1575 C CZ3 . TRP A 227 ? 0.27710 0.30132 0.29700 -0.05990 -0.01733 0.00081  226 TRP A CZ3 
1576 C CH2 . TRP A 227 ? 0.28555 0.32098 0.30825 -0.05503 -0.01955 -0.00083 226 TRP A CH2 
1577 N N   . SER A 228 ? 0.21868 0.23509 0.23707 -0.03330 -0.00303 0.01310  227 SER A N   
1578 C CA  . SER A 228 ? 0.23358 0.25082 0.25236 -0.02779 -0.00237 0.01346  227 SER A CA  
1579 C C   . SER A 228 ? 0.23261 0.24173 0.24808 -0.02642 -0.00356 0.01315  227 SER A C   
1580 O O   . SER A 228 ? 0.21462 0.22457 0.23040 -0.02321 -0.00365 0.01312  227 SER A O   
1581 C CB  . SER A 228 ? 0.23554 0.25467 0.25478 -0.02535 0.00095  0.01479  227 SER A CB  
1582 O OG  . SER A 228 ? 0.25491 0.26654 0.27017 -0.02675 0.00197  0.01511  227 SER A OG  
1583 N N   . LEU A 229 ? 0.22017 0.22233 0.23241 -0.02856 -0.00435 0.01321  228 LEU A N   
1584 C CA  . LEU A 229 ? 0.21137 0.20835 0.22150 -0.02662 -0.00589 0.01285  228 LEU A CA  
1585 C C   . LEU A 229 ? 0.21121 0.20692 0.22061 -0.02524 -0.00805 0.01124  228 LEU A C   
1586 O O   . LEU A 229 ? 0.22281 0.21914 0.23260 -0.02201 -0.00839 0.01077  228 LEU A O   
1587 C CB  . LEU A 229 ? 0.23102 0.22138 0.23703 -0.02821 -0.00670 0.01361  228 LEU A CB  
1588 C CG  . LEU A 229 ? 0.23388 0.22454 0.23884 -0.02881 -0.00482 0.01454  228 LEU A CG  
1589 C CD1 . LEU A 229 ? 0.25887 0.24331 0.25814 -0.03073 -0.00562 0.01561  228 LEU A CD1 
1590 C CD2 . LEU A 229 ? 0.23911 0.23124 0.24565 -0.02668 -0.00477 0.01407  228 LEU A CD2 
1591 N N   . GLY A 230 ? 0.22419 0.21821 0.23221 -0.02796 -0.00934 0.01012  229 GLY A N   
1592 C CA  . GLY A 230 ? 0.26668 0.25881 0.27271 -0.02652 -0.01137 0.00775  229 GLY A CA  
1593 C C   . GLY A 230 ? 0.24642 0.24664 0.25498 -0.02336 -0.01077 0.00725  229 GLY A C   
1594 O O   . GLY A 230 ? 0.22190 0.22154 0.22863 -0.01980 -0.01125 0.00599  229 GLY A O   
1595 N N   . ILE A 231 ? 0.20280 0.21072 0.21490 -0.02398 -0.00951 0.00843  230 ILE A N   
1596 C CA  . ILE A 231 ? 0.22429 0.23878 0.23745 -0.02021 -0.00877 0.00894  230 ILE A CA  
1597 C C   . ILE A 231 ? 0.23831 0.25103 0.25114 -0.01697 -0.00667 0.01047  230 ILE A C   
1598 O O   . ILE A 231 ? 0.22889 0.24314 0.24014 -0.01400 -0.00630 0.01029  230 ILE A O   
1599 C CB  . ILE A 231 ? 0.21895 0.24128 0.23563 -0.02004 -0.00762 0.01052  230 ILE A CB  
1600 C CG1 . ILE A 231 ? 0.23336 0.26085 0.25225 -0.02437 -0.00961 0.00896  230 ILE A CG1 
1601 C CG2 . ILE A 231 ? 0.23084 0.25820 0.24686 -0.01501 -0.00688 0.01191  230 ILE A CG2 
1602 C CD1 . ILE A 231 ? 0.21164 0.24214 0.22871 -0.02506 -0.01310 0.00608  230 ILE A CD1 
1603 N N   . LEU A 232 ? 0.21321 0.22309 0.22724 -0.01808 -0.00520 0.01186  231 LEU A N   
1604 C CA  . LEU A 232 ? 0.21169 0.22079 0.22626 -0.01670 -0.00343 0.01305  231 LEU A CA  
1605 C C   . LEU A 232 ? 0.22189 0.23064 0.23595 -0.01510 -0.00444 0.01177  231 LEU A C   
1606 O O   . LEU A 232 ? 0.22927 0.24116 0.24422 -0.01338 -0.00274 0.01249  231 LEU A O   
1607 C CB  . LEU A 232 ? 0.18874 0.19460 0.20382 -0.01894 -0.00266 0.01380  231 LEU A CB  
1608 C CG  . LEU A 232 ? 0.23007 0.23564 0.24622 -0.01923 -0.00143 0.01448  231 LEU A CG  
1609 C CD1 . LEU A 232 ? 0.22344 0.22967 0.23942 -0.01826 0.00146  0.01625  231 LEU A CD1 
1610 C CD2 . LEU A 232 ? 0.21009 0.21212 0.22547 -0.02185 -0.00181 0.01426  231 LEU A CD2 
1611 N N   . LEU A 233 ? 0.21017 0.21480 0.22249 -0.01547 -0.00682 0.01012  232 LEU A N   
1612 C CA  . LEU A 233 ? 0.20980 0.21385 0.22126 -0.01232 -0.00772 0.00879  232 LEU A CA  
1613 C C   . LEU A 233 ? 0.22166 0.22803 0.23092 -0.00923 -0.00738 0.00720  232 LEU A C   
1614 O O   . LEU A 233 ? 0.23114 0.24181 0.24124 -0.00593 -0.00592 0.00706  232 LEU A O   
1615 C CB  . LEU A 233 ? 0.20132 0.19756 0.20938 -0.01252 -0.01038 0.00773  232 LEU A CB  
1616 C CG  . LEU A 233 ? 0.24835 0.24276 0.25457 -0.00750 -0.01161 0.00624  232 LEU A CG  
1617 C CD1 . LEU A 233 ? 0.24491 0.24842 0.25661 -0.00518 -0.01034 0.00734  232 LEU A CD1 
1618 C CD2 . LEU A 233 ? 0.24970 0.23337 0.25067 -0.00732 -0.01426 0.00598  232 LEU A CD2 
1619 N N   . TYR A 234 ? 0.19939 0.20411 0.20576 -0.01042 -0.00869 0.00585  233 TYR A N   
1620 C CA  . TYR A 234 ? 0.20818 0.21551 0.21118 -0.00761 -0.00868 0.00414  233 TYR A CA  
1621 C C   . TYR A 234 ? 0.26357 0.27800 0.26832 -0.00558 -0.00541 0.00678  233 TYR A C   
1622 O O   . TYR A 234 ? 0.24106 0.25849 0.24376 -0.00208 -0.00379 0.00633  233 TYR A O   
1623 C CB  . TYR A 234 ? 0.21165 0.21869 0.21242 -0.01034 -0.01108 0.00251  233 TYR A CB  
1624 C CG  . TYR A 234 ? 0.25944 0.26849 0.25502 -0.00762 -0.01209 -0.00003 233 TYR A CG  
1625 C CD1 . TYR A 234 ? 0.21774 0.23410 0.21286 -0.00486 -0.01031 0.00196  233 TYR A CD1 
1626 C CD2 . TYR A 234 ? 0.22885 0.23106 0.21842 -0.00766 -0.01480 -0.00442 233 TYR A CD2 
1627 C CE1 . TYR A 234 ? 0.26056 0.27900 0.24950 -0.00198 -0.01128 -0.00023 233 TYR A CE1 
1628 C CE2 . TYR A 234 ? 0.24686 0.25060 0.23014 -0.00500 -0.01593 -0.00742 233 TYR A CE2 
1629 C CZ  . TYR A 234 ? 0.28149 0.29421 0.26462 -0.00205 -0.01416 -0.00519 233 TYR A CZ  
1630 O OH  . TYR A 234 ? 0.28793 0.30251 0.26355 0.00095  -0.01527 -0.00792 233 TYR A OH  
1631 N N   . ASP A 235 ? 0.22483 0.24114 0.23247 -0.00766 -0.00405 0.00965  234 ASP A N   
1632 C CA  . ASP A 235 ? 0.21082 0.23060 0.21880 -0.00645 -0.00070 0.01280  234 ASP A CA  
1633 C C   . ASP A 235 ? 0.22524 0.24732 0.23541 -0.00594 0.00186  0.01356  234 ASP A C   
1634 O O   . ASP A 235 ? 0.22714 0.25294 0.23564 -0.00405 0.00466  0.01496  234 ASP A O   
1635 C CB  . ASP A 235 ? 0.22229 0.24037 0.23236 -0.00860 0.00022  0.01522  234 ASP A CB  
1636 C CG  . ASP A 235 ? 0.27857 0.29627 0.28751 -0.00783 0.00379  0.01879  234 ASP A CG  
1637 O OD1 . ASP A 235 ? 0.26793 0.28762 0.27304 -0.00498 0.00505  0.02036  234 ASP A OD1 
1638 O OD2 . ASP A 235 ? 0.24843 0.26251 0.25920 -0.01030 0.00535  0.02009  234 ASP A OD2 
1639 N N   A MET A 236 ? 0.21064 0.23178 0.22450 -0.00754 0.00093  0.01273  235 MET A N   
1640 N N   B MET A 236 ? 0.21046 0.23154 0.22443 -0.00772 0.00101  0.01287  235 MET A N   
1641 C CA  A MET A 236 ? 0.20674 0.23322 0.22453 -0.00747 0.00298  0.01341  235 MET A CA  
1642 C CA  B MET A 236 ? 0.20683 0.23318 0.22464 -0.00745 0.00283  0.01330  235 MET A CA  
1643 C C   A MET A 236 ? 0.22579 0.25682 0.24241 -0.00278 0.00344  0.01146  235 MET A C   
1644 C C   B MET A 236 ? 0.22666 0.25740 0.24268 -0.00272 0.00352  0.01152  235 MET A C   
1645 O O   A MET A 236 ? 0.24458 0.28311 0.26359 -0.00193 0.00674  0.01265  235 MET A O   
1646 O O   B MET A 236 ? 0.25405 0.29140 0.27103 -0.00174 0.00708  0.01294  235 MET A O   
1647 C CB  A MET A 236 ? 0.22004 0.24569 0.24181 -0.00989 0.00107  0.01297  235 MET A CB  
1648 C CB  B MET A 236 ? 0.21133 0.23669 0.23268 -0.00905 0.00047  0.01239  235 MET A CB  
1649 C CG  A MET A 236 ? 0.20184 0.22455 0.22486 -0.01458 0.00200  0.01484  235 MET A CG  
1650 C CG  B MET A 236 ? 0.23413 0.25556 0.25653 -0.01359 0.00025  0.01373  235 MET A CG  
1651 S SD  A MET A 236 ? 0.22715 0.25126 0.25412 -0.01734 -0.00032 0.01399  235 MET A SD  
1652 S SD  B MET A 236 ? 0.23893 0.26034 0.26386 -0.01478 -0.00293 0.01261  235 MET A SD  
1653 C CE  A MET A 236 ? 0.20834 0.22539 0.23123 -0.01542 -0.00416 0.01238  235 MET A CE  
1654 C CE  B MET A 236 ? 0.20142 0.21722 0.22516 -0.01984 -0.00242 0.01366  235 MET A CE  
1655 N N   . VAL A 237 ? 0.21917 0.24544 0.23172 0.00019  0.00051  0.00835  236 VAL A N   
1656 C CA  . VAL A 237 ? 0.21503 0.24389 0.22514 0.00576  0.00104  0.00585  236 VAL A CA  
1657 C C   . VAL A 237 ? 0.26808 0.29732 0.27164 0.00838  0.00233  0.00477  236 VAL A C   
1658 O O   . VAL A 237 ? 0.28124 0.31405 0.28216 0.01341  0.00407  0.00292  236 VAL A O   
1659 C CB  . VAL A 237 ? 0.22621 0.24729 0.23334 0.00861  -0.00261 0.00266  236 VAL A CB  
1660 C CG1 . VAL A 237 ? 0.23347 0.25542 0.24609 0.00740  -0.00405 0.00400  236 VAL A CG1 
1661 C CG2 . VAL A 237 ? 0.25484 0.26540 0.25598 0.00605  -0.00578 0.00083  236 VAL A CG2 
1662 N N   . CYS A 238 ? 0.24954 0.27617 0.25004 0.00581  0.00153  0.00577  237 CYS A N   
1663 C CA  . CYS A 238 ? 0.28978 0.31772 0.28325 0.00843  0.00213  0.00497  237 CYS A CA  
1664 C C   . CYS A 238 ? 0.29333 0.32611 0.28652 0.00765  0.00571  0.00955  237 CYS A C   
1665 O O   . CYS A 238 ? 0.27727 0.31228 0.26378 0.01065  0.00694  0.00968  237 CYS A O   
1666 C CB  . CYS A 238 ? 0.26713 0.28927 0.25590 0.00699  -0.00247 0.00208  237 CYS A CB  
1667 S SG  . CYS A 238 ? 0.31941 0.33215 0.30352 0.00843  -0.00617 -0.00385 237 CYS A SG  
1668 N N   . GLY A 239 ? 0.25504 0.28805 0.25376 0.00389  0.00741  0.01327  238 GLY A N   
1669 C CA  . GLY A 239 ? 0.26310 0.29744 0.26025 0.00302  0.01115  0.01797  238 GLY A CA  
1670 C C   . GLY A 239 ? 0.30868 0.33913 0.30253 0.00292  0.00941  0.01986  238 GLY A C   
1671 O O   . GLY A 239 ? 0.30055 0.32938 0.29202 0.00275  0.01238  0.02424  238 GLY A O   
1672 N N   . ASP A 240 ? 0.25009 0.27916 0.24356 0.00313  0.00485  0.01685  239 ASP A N   
1673 C CA  . ASP A 240 ? 0.27216 0.30037 0.26504 0.00314  0.00301  0.01844  239 ASP A CA  
1674 C C   . ASP A 240 ? 0.30007 0.32807 0.29603 0.00093  -0.00146 0.01459  239 ASP A C   
1675 O O   . ASP A 240 ? 0.26859 0.29506 0.26461 -0.00003 -0.00329 0.01088  239 ASP A O   
1676 C CB  . ASP A 240 ? 0.30054 0.33168 0.28599 0.00739  0.00280  0.02017  239 ASP A CB  
1677 C CG  . ASP A 240 ? 0.33894 0.36980 0.32391 0.00904  0.00229  0.02356  239 ASP A CG  
1678 O OD1 . ASP A 240 ? 0.29422 0.32182 0.28423 0.00685  0.00298  0.02460  239 ASP A OD1 
1679 O OD2 . ASP A 240 ? 0.38406 0.41807 0.36288 0.01327  0.00114  0.02512  239 ASP A OD2 
1680 N N   . ILE A 241 ? 0.23068 0.25987 0.22884 0.00027  -0.00285 0.01569  240 ILE A N   
1681 C CA  . ILE A 241 ? 0.23511 0.26542 0.23692 -0.00293 -0.00629 0.01278  240 ILE A CA  
1682 C C   . ILE A 241 ? 0.23874 0.27267 0.23715 -0.00294 -0.01033 0.00903  240 ILE A C   
1683 O O   . ILE A 241 ? 0.25906 0.29646 0.25219 0.00065  -0.01086 0.00927  240 ILE A O   
1684 C CB  . ILE A 241 ? 0.28352 0.31670 0.28893 -0.00285 -0.00599 0.01507  240 ILE A CB  
1685 C CG1 . ILE A 241 ? 0.26107 0.30026 0.26333 0.00204  -0.00666 0.01722  240 ILE A CG1 
1686 C CG2 . ILE A 241 ? 0.25105 0.27825 0.25835 -0.00353 -0.00232 0.01773  240 ILE A CG2 
1687 C CD1 . ILE A 241 ? 0.31368 0.35674 0.31954 0.00392  -0.00628 0.01938  240 ILE A CD1 
1688 N N   . PRO A 242 ? 0.24852 0.28093 0.24870 -0.00729 -0.01329 0.00549  241 PRO A N   
1689 C CA  . PRO A 242 ? 0.25987 0.29354 0.25573 -0.00853 -0.01737 0.00106  241 PRO A CA  
1690 C C   . PRO A 242 ? 0.31381 0.35813 0.31127 -0.00905 -0.02063 0.00077  241 PRO A C   
1691 O O   . PRO A 242 ? 0.27039 0.31824 0.26265 -0.00812 -0.02391 -0.00208 241 PRO A O   
1692 C CB  . PRO A 242 ? 0.23131 0.25694 0.22798 -0.01385 -0.01885 -0.00203 241 PRO A CB  
1693 C CG  . PRO A 242 ? 0.24325 0.26916 0.24670 -0.01630 -0.01664 0.00123  241 PRO A CG  
1694 C CD  . PRO A 242 ? 0.24414 0.27163 0.24871 -0.01160 -0.01284 0.00530  241 PRO A CD  
1695 N N   . PHE A 243 ? 0.23211 0.28264 0.23640 -0.00997 -0.01991 0.00345  242 PHE A N   
1696 C CA  . PHE A 243 ? 0.24006 0.30351 0.24814 -0.01075 -0.02328 0.00288  242 PHE A CA  
1697 C C   . PHE A 243 ? 0.30801 0.37848 0.31751 -0.00392 -0.02140 0.00765  242 PHE A C   
1698 O O   . PHE A 243 ? 0.28148 0.34716 0.29299 -0.00199 -0.01725 0.01110  242 PHE A O   
1699 C CB  . PHE A 243 ? 0.25349 0.32026 0.26902 -0.01772 -0.02397 0.00159  242 PHE A CB  
1700 C CG  . PHE A 243 ? 0.29555 0.35175 0.30872 -0.02458 -0.02510 -0.00211 242 PHE A CG  
1701 C CD1 . PHE A 243 ? 0.28336 0.33415 0.28941 -0.02592 -0.02839 -0.00651 242 PHE A CD1 
1702 C CD2 . PHE A 243 ? 0.22848 0.27866 0.24499 -0.02910 -0.02275 -0.00112 242 PHE A CD2 
1703 C CE1 . PHE A 243 ? 0.28041 0.31859 0.28274 -0.03146 -0.02931 -0.00987 242 PHE A CE1 
1704 C CE2 . PHE A 243 ? 0.27229 0.31061 0.28513 -0.03485 -0.02375 -0.00387 242 PHE A CE2 
1705 C CZ  . PHE A 243 ? 0.27798 0.30963 0.28369 -0.03585 -0.02703 -0.00823 242 PHE A CZ  
1706 N N   . GLU A 244 ? 0.31155 0.39277 0.31926 -0.00011 -0.02477 0.00771  243 GLU A N   
1707 C CA  . GLU A 244 ? 0.28177 0.37017 0.29056 0.00726  -0.02368 0.01234  243 GLU A CA  
1708 C C   . GLU A 244 ? 0.35249 0.45844 0.36923 0.00716  -0.02728 0.01152  243 GLU A C   
1709 O O   . GLU A 244 ? 0.44021 0.55200 0.45976 0.01352  -0.02568 0.01530  243 GLU A O   
1710 C CB  . GLU A 244 ? 0.32314 0.41047 0.32219 0.01440  -0.02413 0.01479  243 GLU A CB  
1711 C CG  . GLU A 244 ? 0.40782 0.48039 0.39980 0.01572  -0.01922 0.01713  243 GLU A CG  
1712 C CD  . GLU A 244 ? 0.43687 0.50122 0.43002 0.01836  -0.01379 0.02213  243 GLU A CD  
1713 O OE1 . GLU A 244 ? 0.34202 0.41095 0.33863 0.02204  -0.01359 0.02456  243 GLU A OE1 
1714 O OE2 . GLU A 244 ? 0.44989 0.50338 0.44041 0.01675  -0.00974 0.02331  243 GLU A OE2 
1715 N N   . HIS A 245 ? 0.34065 0.45517 0.36099 0.00016  -0.03198 0.00662  244 HIS A N   
1716 C CA  . HIS A 245 ? 0.29480 0.42971 0.32354 -0.00085 -0.03612 0.00537  244 HIS A CA  
1717 C C   . HIS A 245 ? 0.30669 0.44538 0.34451 -0.01125 -0.03600 0.00236  244 HIS A C   
1718 O O   . HIS A 245 ? 0.28802 0.41322 0.32303 -0.01855 -0.03509 -0.00025 244 HIS A O   
1719 C CB  . HIS A 245 ? 0.33398 0.47876 0.35818 -0.00064 -0.04291 0.00201  244 HIS A CB  
1720 C CG  . HIS A 245 ? 0.41154 0.55113 0.42456 0.00895  -0.04283 0.00510  244 HIS A CG  
1721 N ND1 . HIS A 245 ? 0.50836 0.65610 0.52056 0.01934  -0.04269 0.01021  244 HIS A ND1 
1722 C CD2 . HIS A 245 ? 0.44125 0.56780 0.44274 0.01005  -0.04230 0.00423  244 HIS A CD2 
1723 C CE1 . HIS A 245 ? 0.57810 0.71721 0.57815 0.02565  -0.04213 0.01266  244 HIS A CE1 
1724 N NE2 . HIS A 245 ? 0.53528 0.66253 0.52913 0.02003  -0.04167 0.00902  244 HIS A NE2 
1725 N N   . ASP A 246 ? 0.32670 0.48428 0.37513 -0.01143 -0.03672 0.00303  245 ASP A N   
1726 C CA  . ASP A 246 ? 0.32438 0.48802 0.38196 -0.02181 -0.03598 0.00084  245 ASP A CA  
1727 C C   . ASP A 246 ? 0.32588 0.48527 0.38097 -0.03325 -0.04034 -0.00474 245 ASP A C   
1728 O O   . ASP A 246 ? 0.30790 0.45647 0.36319 -0.04207 -0.03822 -0.00612 245 ASP A O   
1729 C CB  . ASP A 246 ? 0.34949 0.53929 0.41952 -0.02023 -0.03702 0.00176  245 ASP A CB  
1730 C CG  . ASP A 246 ? 0.32808 0.51992 0.40046 -0.00942 -0.03176 0.00682  245 ASP A CG  
1731 O OD1 . ASP A 246 ? 0.32467 0.49673 0.38917 -0.00487 -0.02735 0.00943  245 ASP A OD1 
1732 O OD2 . ASP A 246 ? 0.33490 0.54844 0.41705 -0.00553 -0.03206 0.00793  245 ASP A OD2 
1733 N N   . GLU A 247 ? 0.28205 0.44860 0.33342 -0.03299 -0.04658 -0.00804 246 GLU A N   
1734 C CA  . GLU A 247 ? 0.27528 0.43695 0.32295 -0.04392 -0.05127 -0.01423 246 GLU A CA  
1735 C C   . GLU A 247 ? 0.31401 0.44842 0.35054 -0.04601 -0.04866 -0.01558 246 GLU A C   
1736 O O   . GLU A 247 ? 0.31930 0.44361 0.35352 -0.05618 -0.04989 -0.01959 246 GLU A O   
1737 C CB  . GLU A 247 ? 0.36730 0.54104 0.41093 -0.04167 -0.05865 -0.01773 246 GLU A CB  
1738 C CG  . GLU A 247 ? 0.46948 0.67337 0.52493 -0.03987 -0.06263 -0.01703 246 GLU A CG  
1739 C CD  . GLU A 247 ? 0.60781 0.82028 0.66524 -0.02509 -0.05976 -0.01047 246 GLU A CD  
1740 O OE1 . GLU A 247 ? 0.42858 0.62318 0.47806 -0.01722 -0.05465 -0.00645 246 GLU A OE1 
1741 N N   . GLU A 248 ? 0.30709 0.42940 0.33652 -0.03652 -0.04505 -0.01223 247 GLU A N   
1742 C CA  . GLU A 248 ? 0.32447 0.42387 0.34501 -0.03729 -0.04221 -0.01309 247 GLU A CA  
1743 C C   . GLU A 248 ? 0.30785 0.39823 0.33276 -0.04169 -0.03740 -0.01082 247 GLU A C   
1744 O O   . GLU A 248 ? 0.32143 0.39583 0.34131 -0.04697 -0.03687 -0.01301 247 GLU A O   
1745 C CB  . GLU A 248 ? 0.34057 0.43283 0.35369 -0.02672 -0.03953 -0.00997 247 GLU A CB  
1746 C CG  . GLU A 248 ? 0.37112 0.46938 0.37671 -0.02180 -0.04382 -0.01194 247 GLU A CG  
1747 C CD  . GLU A 248 ? 0.42259 0.51563 0.42150 -0.01162 -0.04015 -0.00745 247 GLU A CD  
1748 O OE1 . GLU A 248 ? 0.36273 0.45503 0.36573 -0.00741 -0.03556 -0.00216 247 GLU A OE1 
1749 O OE2 . GLU A 248 ? 0.53998 0.62919 0.52885 -0.00820 -0.04163 -0.00929 247 GLU A OE2 
1750 N N   . ILE A 249 ? 0.27233 0.37166 0.30521 -0.03867 -0.03380 -0.00636 248 ILE A N   
1751 C CA  . ILE A 249 ? 0.25613 0.34789 0.29218 -0.04254 -0.02922 -0.00415 248 ILE A CA  
1752 C C   . ILE A 249 ? 0.30864 0.40018 0.34739 -0.05449 -0.03078 -0.00708 248 ILE A C   
1753 O O   . ILE A 249 ? 0.32795 0.40365 0.36252 -0.05931 -0.02880 -0.00713 248 ILE A O   
1754 C CB  . ILE A 249 ? 0.24724 0.35019 0.29075 -0.03710 -0.02531 0.00032  248 ILE A CB  
1755 C CG1 . ILE A 249 ? 0.26651 0.36478 0.30542 -0.02630 -0.02323 0.00350  248 ILE A CG1 
1756 C CG2 . ILE A 249 ? 0.26267 0.35944 0.30881 -0.04189 -0.02078 0.00212  248 ILE A CG2 
1757 C CD1 . ILE A 249 ? 0.27660 0.38465 0.32087 -0.01948 -0.02002 0.00737  248 ILE A CD1 
1758 N N   . ILE A 250 ? 0.28661 0.39597 0.33229 -0.05970 -0.03437 -0.00929 249 ILE A N   
1759 C CA  . ILE A 250 ? 0.29184 0.40158 0.34084 -0.07274 -0.03519 -0.01163 249 ILE A CA  
1760 C C   . ILE A 250 ? 0.35907 0.45428 0.39880 -0.07985 -0.03975 -0.01713 249 ILE A C   
1761 O O   . ILE A 250 ? 0.33807 0.42560 0.37696 -0.09119 -0.03994 -0.01897 249 ILE A O   
1762 C CB  . ILE A 250 ? 0.37284 0.51012 0.43516 -0.07705 -0.03657 -0.01167 249 ILE A CB  
1763 C CG1 . ILE A 250 ? 0.31298 0.46568 0.37651 -0.07537 -0.04337 -0.01534 249 ILE A CG1 
1764 C CG2 . ILE A 250 ? 0.34474 0.49460 0.41497 -0.06870 -0.03143 -0.00646 249 ILE A CG2 
1765 C CD1 . ILE A 250 ? 0.37985 0.56247 0.45754 -0.08012 -0.04577 -0.01596 249 ILE A CD1 
1766 N N   . GLY A 251 ? 0.28444 0.37377 0.31581 -0.07336 -0.04297 -0.01972 250 GLY A N   
1767 C CA  . GLY A 251 ? 0.35583 0.43243 0.37747 -0.07928 -0.04766 -0.02590 250 GLY A CA  
1768 C C   . GLY A 251 ? 0.44580 0.49500 0.45719 -0.08179 -0.04535 -0.02671 250 GLY A C   
1769 O O   . GLY A 251 ? 0.58009 0.61603 0.58405 -0.08988 -0.04840 -0.03165 250 GLY A O   
1770 N N   . GLY A 252 ? 0.39092 0.43076 0.40104 -0.07471 -0.04033 -0.02212 251 GLY A N   
1771 C CA  . GLY A 252 ? 0.60261 0.61829 0.60364 -0.07594 -0.03836 -0.02226 251 GLY A CA  
1772 C C   . GLY A 252 ? 0.65815 0.65761 0.64692 -0.06978 -0.04000 -0.02597 251 GLY A C   
1773 O O   . GLY A 252 ? 0.64361 0.62220 0.62334 -0.07184 -0.03982 -0.02771 251 GLY A O   
1774 N N   . GLN A 253 ? 0.45675 0.46458 0.44407 -0.06164 -0.04127 -0.02702 252 GLN A N   
1775 C CA  . GLN A 253 ? 0.40557 0.39995 0.38111 -0.05529 -0.04219 -0.03070 252 GLN A CA  
1776 C C   . GLN A 253 ? 0.37183 0.36907 0.34825 -0.04394 -0.03811 -0.02645 252 GLN A C   
1777 O O   . GLN A 253 ? 0.40763 0.42025 0.38942 -0.03944 -0.03739 -0.02358 252 GLN A O   
1778 C CB  . GLN A 253 ? 0.46512 0.46497 0.43518 -0.05684 -0.04750 -0.03667 252 GLN A CB  
1779 C CG  . GLN A 253 ? 0.58962 0.58362 0.55720 -0.06961 -0.05197 -0.04206 252 GLN A CG  
1780 C CD  . GLN A 253 ? 0.67599 0.66414 0.63182 -0.07055 -0.05726 -0.04992 252 GLN A CD  
1781 N N   . VAL A 254 ? 0.31322 0.29560 0.28410 -0.03938 -0.03552 -0.02600 253 VAL A N   
1782 C CA  . VAL A 254 ? 0.27634 0.26153 0.24875 -0.03007 -0.03150 -0.02217 253 VAL A CA  
1783 C C   . VAL A 254 ? 0.35912 0.33795 0.32157 -0.02324 -0.03177 -0.02605 253 VAL A C   
1784 O O   . VAL A 254 ? 0.37978 0.34312 0.33433 -0.02176 -0.03199 -0.02921 253 VAL A O   
1785 C CB  . VAL A 254 ? 0.28549 0.26261 0.26064 -0.02936 -0.02832 -0.01841 253 VAL A CB  
1786 C CG1 . VAL A 254 ? 0.31732 0.29947 0.29523 -0.02106 -0.02454 -0.01481 253 VAL A CG1 
1787 C CG2 . VAL A 254 ? 0.34452 0.32739 0.32799 -0.03645 -0.02772 -0.01496 253 VAL A CG2 
1788 N N   . PHE A 255 ? 0.30751 0.29773 0.26937 -0.01844 -0.03148 -0.02565 254 PHE A N   
1789 C CA  . PHE A 255 ? 0.30184 0.28884 0.25443 -0.01100 -0.03051 -0.02847 254 PHE A CA  
1790 C C   . PHE A 255 ? 0.31700 0.30773 0.27356 -0.00395 -0.02504 -0.02357 254 PHE A C   
1791 O O   . PHE A 255 ? 0.28154 0.28261 0.24591 -0.00369 -0.02277 -0.01826 254 PHE A O   
1792 C CB  . PHE A 255 ? 0.30223 0.29978 0.25062 -0.00995 -0.03315 -0.03034 254 PHE A CB  
1793 C CG  . PHE A 255 ? 0.35447 0.35206 0.29367 -0.00152 -0.03085 -0.03173 254 PHE A CG  
1794 C CD1 . PHE A 255 ? 0.35961 0.34618 0.28636 0.00045  -0.03271 -0.03865 254 PHE A CD1 
1795 C CD2 . PHE A 255 ? 0.28955 0.29737 0.23170 0.00429  -0.02641 -0.02610 254 PHE A CD2 
1796 C CE1 . PHE A 255 ? 0.34281 0.33044 0.26040 0.00880  -0.02991 -0.04006 254 PHE A CE1 
1797 C CE2 . PHE A 255 ? 0.30995 0.31876 0.24355 0.01150  -0.02346 -0.02687 254 PHE A CE2 
1798 C CZ  . PHE A 255 ? 0.33312 0.33281 0.25461 0.01411  -0.02508 -0.03388 254 PHE A CZ  
1799 N N   . PHE A 256 ? 0.28278 0.26532 0.23394 0.00175  -0.02290 -0.02551 255 PHE A N   
1800 C CA  . PHE A 256 ? 0.30738 0.29549 0.26326 0.00771  -0.01784 -0.02133 255 PHE A CA  
1801 C C   . PHE A 256 ? 0.31496 0.31095 0.26577 0.01385  -0.01504 -0.02144 255 PHE A C   
1802 O O   . PHE A 256 ? 0.32623 0.31706 0.26695 0.01806  -0.01551 -0.02642 255 PHE A O   
1803 C CB  . PHE A 256 ? 0.30439 0.28223 0.25931 0.01102  -0.01688 -0.02252 255 PHE A CB  
1804 C CG  . PHE A 256 ? 0.29025 0.26413 0.25211 0.00603  -0.01778 -0.01948 255 PHE A CG  
1805 C CD1 . PHE A 256 ? 0.33507 0.29736 0.29360 -0.00008 -0.02140 -0.02176 255 PHE A CD1 
1806 C CD2 . PHE A 256 ? 0.30378 0.28569 0.27488 0.00657  -0.01494 -0.01432 255 PHE A CD2 
1807 C CE1 . PHE A 256 ? 0.29776 0.25679 0.26167 -0.00476 -0.02168 -0.01847 255 PHE A CE1 
1808 C CE2 . PHE A 256 ? 0.30679 0.28526 0.28289 0.00214  -0.01582 -0.01169 255 PHE A CE2 
1809 C CZ  . PHE A 256 ? 0.31770 0.28493 0.28999 -0.00318 -0.01897 -0.01354 255 PHE A CZ  
1810 N N   . ARG A 257 ? 0.31894 0.32624 0.27556 0.01430  -0.01188 -0.01590 256 ARG A N   
1811 C CA  . ARG A 257 ? 0.37188 0.38698 0.32341 0.01910  -0.00867 -0.01448 256 ARG A CA  
1812 C C   . ARG A 257 ? 0.35788 0.37706 0.31147 0.02428  -0.00281 -0.01250 256 ARG A C   
1813 O O   . ARG A 257 ? 0.36755 0.39308 0.31631 0.02834  0.00093  -0.01123 256 ARG A O   
1814 C CB  . ARG A 257 ? 0.31506 0.33850 0.27032 0.01682  -0.00822 -0.00901 256 ARG A CB  
1815 C CG  . ARG A 257 ? 0.34652 0.37279 0.31271 0.01424  -0.00508 -0.00315 256 ARG A CG  
1816 C CD  . ARG A 257 ? 0.37165 0.40261 0.34023 0.01227  -0.00565 0.00132  256 ARG A CD  
1817 N NE  . ARG A 257 ? 0.38091 0.41100 0.35192 0.00822  -0.01080 -0.00084 256 ARG A NE  
1818 C CZ  . ARG A 257 ? 0.42375 0.45919 0.39665 0.00740  -0.01254 0.00168  256 ARG A CZ  
1819 N NH1 . ARG A 257 ? 0.38309 0.42239 0.35444 0.01070  -0.00976 0.00676  256 ARG A NH1 
1820 N NH2 . ARG A 257 ? 0.37077 0.40773 0.34698 0.00331  -0.01698 -0.00077 256 ARG A NH2 
1821 N N   . GLN A 258 ? 0.32279 0.33955 0.28337 0.02418  -0.00195 -0.01207 257 GLN A N   
1822 C CA  . GLN A 258 ? 0.32269 0.34552 0.28707 0.02899  0.00289  -0.01078 257 GLN A CA  
1823 C C   . GLN A 258 ? 0.28964 0.30376 0.25220 0.03280  0.00097  -0.01526 257 GLN A C   
1824 O O   . GLN A 258 ? 0.28060 0.28328 0.24117 0.02965  -0.00363 -0.01765 257 GLN A O   
1825 C CB  . GLN A 258 ? 0.36310 0.39371 0.33930 0.02509  0.00561  -0.00481 257 GLN A CB  
1826 C CG  . GLN A 258 ? 0.50280 0.54065 0.47956 0.02281  0.00900  0.00018  257 GLN A CG  
1827 C CD  . GLN A 258 ? 0.47582 0.52313 0.45109 0.02691  0.01507  0.00175  257 GLN A CD  
1828 O OE1 . GLN A 258 ? 0.51179 0.56576 0.49341 0.02879  0.01806  0.00196  257 GLN A OE1 
1829 N NE2 . GLN A 258 ? 0.68190 0.73101 0.64865 0.02851  0.01696  0.00297  257 GLN A NE2 
1830 N N   . ARG A 259 ? 0.25939 0.27906 0.22265 0.03973  0.00475  -0.01603 258 ARG A N   
1831 C CA  . ARG A 259 ? 0.26125 0.27312 0.22367 0.04480  0.00312  -0.01926 258 ARG A CA  
1832 C C   . ARG A 259 ? 0.31580 0.32730 0.28825 0.04037  0.00108  -0.01571 258 ARG A C   
1833 O O   . ARG A 259 ? 0.27622 0.30030 0.25908 0.03842  0.00372  -0.01127 258 ARG A O   
1834 C CB  . ARG A 259 ? 0.29903 0.32051 0.26189 0.05425  0.00797  -0.02039 258 ARG A CB  
1835 C CG  . ARG A 259 ? 0.33337 0.34346 0.29006 0.06274  0.00612  -0.02532 258 ARG A CG  
1836 C CD  . ARG A 259 ? 0.39449 0.40481 0.36008 0.06341  0.00426  -0.02284 258 ARG A CD  
1837 N NE  . ARG A 259 ? 0.36319 0.35709 0.32004 0.07091  0.00139  -0.02713 258 ARG A NE  
1838 C CZ  . ARG A 259 ? 0.50434 0.49549 0.46553 0.07394  -0.00076 -0.02549 258 ARG A CZ  
1839 N NH1 . ARG A 259 ? 0.42072 0.42540 0.39516 0.06974  -0.00072 -0.02030 258 ARG A NH1 
1840 N NH2 . ARG A 259 ? 0.44778 0.42104 0.39861 0.08145  -0.00322 -0.02918 258 ARG A NH2 
1841 N N   . VAL A 260 ? 0.26690 0.26339 0.23531 0.03839  -0.00354 -0.01778 259 VAL A N   
1842 C CA  . VAL A 260 ? 0.25684 0.25064 0.23200 0.03460  -0.00580 -0.01474 259 VAL A CA  
1843 C C   . VAL A 260 ? 0.31699 0.29586 0.28529 0.03987  -0.00856 -0.01774 259 VAL A C   
1844 O O   . VAL A 260 ? 0.32319 0.28752 0.28022 0.04139  -0.01046 -0.02235 259 VAL A O   
1845 C CB  . VAL A 260 ? 0.28674 0.27668 0.26350 0.02484  -0.00830 -0.01273 259 VAL A CB  
1846 C CG1 . VAL A 260 ? 0.27415 0.25917 0.25531 0.02131  -0.01053 -0.01011 259 VAL A CG1 
1847 C CG2 . VAL A 260 ? 0.28006 0.28327 0.26279 0.02104  -0.00547 -0.00919 259 VAL A CG2 
1848 N N   . SER A 261 ? 0.27256 0.25421 0.24664 0.04288  -0.00899 -0.01525 260 SER A N   
1849 C CA  . SER A 261 ? 0.31969 0.28711 0.28659 0.04987  -0.01139 -0.01728 260 SER A CA  
1850 C C   . SER A 261 ? 0.36627 0.31243 0.32397 0.04357  -0.01522 -0.01843 260 SER A C   
1851 O O   . SER A 261 ? 0.30212 0.24883 0.26294 0.03378  -0.01619 -0.01639 260 SER A O   
1852 C CB  . SER A 261 ? 0.36922 0.34513 0.34436 0.05375  -0.01196 -0.01367 260 SER A CB  
1853 O OG  . SER A 261 ? 0.31013 0.28473 0.28957 0.04500  -0.01411 -0.00990 260 SER A OG  
1854 N N   . SEP A 262 ? 0.33821 0.26545 0.28430 0.04923  -0.01709 -0.02168 261 SEP A N   
1855 C CA  . SEP A 262 ? 0.34873 0.25406 0.28512 0.04237  -0.02039 -0.02277 261 SEP A CA  
1856 C CB  . SEP A 262 ? 0.43903 0.32172 0.36069 0.05060  -0.02178 -0.02692 261 SEP A CB  
1857 O OG  . SEP A 262 ? 0.48555 0.36793 0.40080 0.05556  -0.02030 -0.03268 261 SEP A OG  
1858 C C   . SEP A 262 ? 0.38340 0.28757 0.32480 0.03587  -0.02199 -0.01738 261 SEP A C   
1859 O O   . SEP A 262 ? 0.34814 0.24503 0.28792 0.02569  -0.02337 -0.01662 261 SEP A O   
1860 P P   . SEP A 262 ? 0.61296 0.50126 0.52698 0.07186  -0.01754 -0.03455 261 SEP A P   
1861 O O1P . SEP A 262 ? 0.57574 0.44134 0.47866 0.08118  -0.01969 -0.03504 261 SEP A O1P 
1862 O O2P . SEP A 262 ? 0.38577 0.27216 0.29025 0.07654  -0.01550 -0.04153 261 SEP A O2P 
1863 O O3P . SEP A 262 ? 0.43209 0.34990 0.36417 0.07438  -0.01477 -0.02900 261 SEP A O3P 
1864 N N   . GLU A 263 ? 0.33155 0.24429 0.27909 0.04171  -0.02179 -0.01379 262 GLU A N   
1865 C CA  . GLU A 263 ? 0.35547 0.26776 0.30658 0.03634  -0.02333 -0.00885 262 GLU A CA  
1866 C C   . GLU A 263 ? 0.32484 0.25161 0.28604 0.02609  -0.02204 -0.00652 262 GLU A C   
1867 O O   . GLU A 263 ? 0.30713 0.22829 0.26762 0.01786  -0.02293 -0.00422 262 GLU A O   
1868 C CB  . GLU A 263 ? 0.37900 0.29995 0.33467 0.04538  -0.02401 -0.00606 262 GLU A CB  
1869 C CG  . GLU A 263 ? 0.45845 0.36419 0.40349 0.05740  -0.02557 -0.00764 262 GLU A CG  
1870 C CD  . GLU A 263 ? 0.56834 0.47994 0.51274 0.06762  -0.02333 -0.01221 262 GLU A CD  
1871 O OE2 . GLU A 263 ? 0.45616 0.38277 0.40726 0.06514  -0.02041 -0.01421 262 GLU A OE2 
1872 N N   . CYS A 264 ? 0.29902 0.24421 0.26911 0.02692  -0.01954 -0.00690 263 CYS A N   
1873 C CA  . CYS A 264 ? 0.28522 0.24195 0.26330 0.01842  -0.01815 -0.00478 263 CYS A CA  
1874 C C   . CYS A 264 ? 0.30705 0.25659 0.28079 0.01107  -0.01868 -0.00665 263 CYS A C   
1875 O O   . CYS A 264 ? 0.27479 0.22620 0.25181 0.00346  -0.01878 -0.00449 263 CYS A O   
1876 C CB  . CYS A 264 ? 0.27983 0.25521 0.26653 0.02088  -0.01507 -0.00445 263 CYS A CB  
1877 S SG  . CYS A 264 ? 0.31404 0.30150 0.30933 0.01208  -0.01308 -0.00133 263 CYS A SG  
1878 N N   . GLN A 265 ? 0.30230 0.24514 0.26890 0.01336  -0.01904 -0.01096 264 GLN A N   
1879 C CA  . GLN A 265 ? 0.29312 0.22994 0.25552 0.00591  -0.02047 -0.01330 264 GLN A CA  
1880 C C   . GLN A 265 ? 0.30799 0.23130 0.26657 -0.00122 -0.02254 -0.01208 264 GLN A C   
1881 O O   . GLN A 265 ? 0.30022 0.22636 0.26149 -0.00975 -0.02301 -0.01150 264 GLN A O   
1882 C CB  . GLN A 265 ? 0.28148 0.20956 0.23407 0.00966  -0.02136 -0.01899 264 GLN A CB  
1883 C CG  . GLN A 265 ? 0.30456 0.24608 0.25906 0.01530  -0.01892 -0.02055 264 GLN A CG  
1884 C CD  . GLN A 265 ? 0.36812 0.30089 0.31158 0.01649  -0.02036 -0.02667 264 GLN A CD  
1885 O OE1 . GLN A 265 ? 0.40119 0.31910 0.33700 0.01117  -0.02353 -0.02980 264 GLN A OE1 
1886 N NE2 . GLN A 265 ? 0.31744 0.25922 0.25944 0.02278  -0.01798 -0.02850 264 GLN A NE2 
1887 N N   . HIS A 266 ? 0.29835 0.20677 0.24997 0.00247  -0.02364 -0.01162 265 HIS A N   
1888 C CA  . HIS A 266 ? 0.34872 0.24220 0.29485 -0.00449 -0.02505 -0.00983 265 HIS A CA  
1889 C C   . HIS A 266 ? 0.35111 0.25528 0.30574 -0.01024 -0.02386 -0.00487 265 HIS A C   
1890 O O   . HIS A 266 ? 0.31536 0.21745 0.27029 -0.01944 -0.02383 -0.00382 265 HIS A O   
1891 C CB  . HIS A 266 ? 0.35306 0.22770 0.28881 0.00244  -0.02630 -0.00944 265 HIS A CB  
1892 C CG  . HIS A 266 ? 0.38729 0.24539 0.31615 -0.00413 -0.02719 -0.00631 265 HIS A CG  
1893 N ND1 . HIS A 266 ? 0.42297 0.28555 0.35554 -0.00555 -0.02662 -0.00090 265 HIS A ND1 
1894 C CD2 . HIS A 266 ? 0.47627 0.31281 0.39390 -0.01033 -0.02837 -0.00775 265 HIS A CD2 
1895 C CE1 . HIS A 266 ? 0.50344 0.34845 0.42721 -0.01183 -0.02703 0.00134  265 HIS A CE1 
1896 N NE2 . HIS A 266 ? 0.42700 0.25572 0.34191 -0.01529 -0.02800 -0.00259 265 HIS A NE2 
1897 N N   . LEU A 267 ? 0.29974 0.21616 0.26137 -0.00519 -0.02274 -0.00209 266 LEU A N   
1898 C CA  . LEU A 267 ? 0.32299 0.24846 0.29125 -0.01016 -0.02160 0.00188  266 LEU A CA  
1899 C C   . LEU A 267 ? 0.28670 0.22422 0.26197 -0.01666 -0.02011 0.00146  266 LEU A C   
1900 O O   . LEU A 267 ? 0.27353 0.21207 0.25047 -0.02346 -0.01937 0.00343  266 LEU A O   
1901 C CB  . LEU A 267 ? 0.25268 0.18910 0.22680 -0.00414 -0.02116 0.00405  266 LEU A CB  
1902 C CG  . LEU A 267 ? 0.31428 0.25940 0.29408 -0.00865 -0.02008 0.00738  266 LEU A CG  
1903 C CD1 . LEU A 267 ? 0.26773 0.20130 0.24101 -0.01348 -0.02061 0.01012  266 LEU A CD1 
1904 C CD2 . LEU A 267 ? 0.28832 0.24429 0.27363 -0.00340 -0.02034 0.00859  266 LEU A CD2 
1905 N N   . ILE A 268 ? 0.26227 0.20947 0.24127 -0.01405 -0.01947 -0.00084 267 ILE A N   
1906 C CA  . ILE A 268 ? 0.24622 0.20452 0.23084 -0.01871 -0.01848 -0.00096 267 ILE A CA  
1907 C C   . ILE A 268 ? 0.28245 0.23494 0.26393 -0.02618 -0.01998 -0.00263 267 ILE A C   
1908 O O   . ILE A 268 ? 0.28128 0.24076 0.26757 -0.03194 -0.01917 -0.00098 267 ILE A O   
1909 C CB  . ILE A 268 ? 0.27945 0.24670 0.26589 -0.01408 -0.01773 -0.00291 267 ILE A CB  
1910 C CG1 . ILE A 268 ? 0.25031 0.22668 0.24221 -0.00916 -0.01546 -0.00053 267 ILE A CG1 
1911 C CG2 . ILE A 268 ? 0.26993 0.24618 0.25955 -0.01812 -0.01772 -0.00336 267 ILE A CG2 
1912 C CD1 . ILE A 268 ? 0.23629 0.21945 0.22819 -0.00380 -0.01402 -0.00212 267 ILE A CD1 
1913 N N   . ARG A 269 ? 0.28977 0.22991 0.26317 -0.02630 -0.02210 -0.00622 268 ARG A N   
1914 C CA  . ARG A 269 ? 0.29972 0.23483 0.27038 -0.03502 -0.02384 -0.00837 268 ARG A CA  
1915 C C   . ARG A 269 ? 0.34582 0.27479 0.31619 -0.04205 -0.02298 -0.00503 268 ARG A C   
1916 O O   . ARG A 269 ? 0.31785 0.25134 0.29125 -0.05067 -0.02306 -0.00510 268 ARG A O   
1917 C CB  . ARG A 269 ? 0.33456 0.25414 0.29459 -0.03421 -0.02637 -0.01338 268 ARG A CB  
1918 C CG  . ARG A 269 ? 0.35360 0.28090 0.31301 -0.02938 -0.02726 -0.01745 268 ARG A CG  
1919 C CD  . ARG A 269 ? 0.44035 0.35288 0.38871 -0.03148 -0.03025 -0.02347 268 ARG A CD  
1920 N NE  . ARG A 269 ? 0.50509 0.42590 0.45179 -0.02740 -0.03121 -0.02748 268 ARG A NE  
1921 C CZ  . ARG A 269 ? 0.48606 0.40393 0.42731 -0.01772 -0.03014 -0.02958 268 ARG A CZ  
1922 N NH1 . ARG A 269 ? 0.41558 0.32325 0.35333 -0.01077 -0.02855 -0.02842 268 ARG A NH1 
1923 N NH2 . ARG A 269 ? 0.40088 0.32744 0.34013 -0.01444 -0.03056 -0.03269 268 ARG A NH2 
1924 N N   . TRP A 270 ? 0.31084 0.23085 0.27757 -0.03844 -0.02211 -0.00194 269 TRP A N   
1925 C CA  . TRP A 270 ? 0.33624 0.25008 0.30112 -0.04447 -0.02083 0.00191  269 TRP A CA  
1926 C C   . TRP A 270 ? 0.29185 0.22303 0.26655 -0.04744 -0.01826 0.00481  269 TRP A C   
1927 O O   . TRP A 270 ? 0.29279 0.22648 0.26932 -0.05549 -0.01684 0.00628  269 TRP A O   
1928 C CB  . TRP A 270 ? 0.32546 0.22624 0.28300 -0.03822 -0.02111 0.00458  269 TRP A CB  
1929 C CG  . TRP A 270 ? 0.33786 0.22632 0.28875 -0.04363 -0.02016 0.00860  269 TRP A CG  
1930 C CD1 . TRP A 270 ? 0.36935 0.25538 0.31954 -0.05442 -0.01870 0.00979  269 TRP A CD1 
1931 C CD2 . TRP A 270 ? 0.36397 0.24158 0.30751 -0.03835 -0.02052 0.01229  269 TRP A CD2 
1932 N NE1 . TRP A 270 ? 0.36961 0.24243 0.31146 -0.05645 -0.01753 0.01438  269 TRP A NE1 
1933 C CE2 . TRP A 270 ? 0.36282 0.22989 0.29996 -0.04625 -0.01895 0.01598  269 TRP A CE2 
1934 C CE3 . TRP A 270 ? 0.35775 0.23486 0.29970 -0.02764 -0.02210 0.01296  269 TRP A CE3 
1935 C CZ2 . TRP A 270 ? 0.38225 0.23665 0.30987 -0.04320 -0.01906 0.02056  269 TRP A CZ2 
1936 C CZ3 . TRP A 270 ? 0.38884 0.25510 0.32256 -0.02437 -0.02281 0.01716  269 TRP A CZ3 
1937 C CH2 . TRP A 270 ? 0.40186 0.25600 0.32770 -0.03189 -0.02135 0.02103  269 TRP A CH2 
1938 N N   . CYS A 271 ? 0.27016 0.21322 0.25096 -0.04106 -0.01732 0.00557  270 CYS A N   
1939 C CA  . CYS A 271 ? 0.29895 0.25676 0.28785 -0.04266 -0.01485 0.00766  270 CYS A CA  
1940 C C   . CYS A 271 ? 0.27726 0.24659 0.27214 -0.04738 -0.01469 0.00601  270 CYS A C   
1941 O O   . CYS A 271 ? 0.27856 0.25780 0.27881 -0.05066 -0.01247 0.00781  270 CYS A O   
1942 C CB  . CYS A 271 ? 0.23903 0.20522 0.23227 -0.03558 -0.01410 0.00816  270 CYS A CB  
1943 S SG  . CYS A 271 ? 0.29061 0.24968 0.27977 -0.03034 -0.01456 0.01033  270 CYS A SG  
1944 N N   . LEU A 272 ? 0.26064 0.23008 0.25457 -0.04701 -0.01711 0.00243  271 LEU A N   
1945 C CA  . LEU A 272 ? 0.27564 0.25752 0.27500 -0.05085 -0.01803 0.00052  271 LEU A CA  
1946 C C   . LEU A 272 ? 0.28338 0.25979 0.28014 -0.06031 -0.01977 -0.00152 271 LEU A C   
1947 O O   . LEU A 272 ? 0.29982 0.28340 0.29867 -0.06366 -0.02224 -0.00475 271 LEU A O   
1948 C CB  . LEU A 272 ? 0.26504 0.25197 0.26429 -0.04506 -0.01983 -0.00220 271 LEU A CB  
1949 C CG  . LEU A 272 ? 0.27346 0.26653 0.27572 -0.03720 -0.01762 0.00015  271 LEU A CG  
1950 C CD1 . LEU A 272 ? 0.26703 0.26492 0.26809 -0.03187 -0.01871 -0.00189 271 LEU A CD1 
1951 C CD2 . LEU A 272 ? 0.22838 0.23254 0.23764 -0.03762 -0.01497 0.00336  271 LEU A CD2 
1952 N N   . ALA A 273 ? 0.31915 0.28264 0.31074 -0.06512 -0.01867 0.00038  272 ALA A N   
1953 C CA  . ALA A 273 ? 0.33507 0.29309 0.32440 -0.07598 -0.01956 -0.00089 272 ALA A CA  
1954 C C   . ALA A 273 ? 0.34590 0.32513 0.34637 -0.08215 -0.01845 -0.00047 272 ALA A C   
1955 O O   . ALA A 273 ? 0.30344 0.29508 0.31061 -0.07968 -0.01521 0.00283  272 ALA A O   
1956 C CB  . ALA A 273 ? 0.32741 0.26825 0.30886 -0.07987 -0.01756 0.00256  272 ALA A CB  
1957 N N   . LEU A 274 ? 0.33409 0.31787 0.33637 -0.09007 -0.02129 -0.00415 273 LEU A N   
1958 C CA  . LEU A 274 ? 0.29508 0.30220 0.30930 -0.09568 -0.02073 -0.00398 273 LEU A CA  
1959 C C   . LEU A 274 ? 0.33570 0.34653 0.35360 -0.10278 -0.01604 0.00031  273 LEU A C   
1960 O O   . LEU A 274 ? 0.30728 0.33795 0.33515 -0.10126 -0.01319 0.00255  273 LEU A O   
1961 C CB  . LEU A 274 ? 0.30223 0.31395 0.31748 -0.10403 -0.02542 -0.00919 273 LEU A CB  
1962 C CG  . LEU A 274 ? 0.33166 0.34905 0.34605 -0.09676 -0.02989 -0.01340 273 LEU A CG  
1963 C CD1 . LEU A 274 ? 0.37870 0.40229 0.39392 -0.10604 -0.03507 -0.01897 273 LEU A CD1 
1964 C CD2 . LEU A 274 ? 0.33158 0.36905 0.35481 -0.08680 -0.02847 -0.01080 273 LEU A CD2 
1965 N N   . ARG A 275 ? 0.32966 0.32131 0.33882 -0.11024 -0.01488 0.00162  274 ARG A N   
1966 C CA  . ARG A 275 ? 0.34275 0.33782 0.35418 -0.11709 -0.00976 0.00625  274 ARG A CA  
1967 C C   . ARG A 275 ? 0.35698 0.34621 0.36434 -0.10776 -0.00625 0.01059  274 ARG A C   
1968 O O   . ARG A 275 ? 0.35054 0.32081 0.34785 -0.10168 -0.00769 0.01087  274 ARG A O   
1969 C CB  . ARG A 275 ? 0.41947 0.39543 0.42198 -0.12965 -0.00944 0.00674  274 ARG A CB  
1970 C CG  . ARG A 275 ? 0.51750 0.49136 0.51826 -0.13604 -0.00333 0.01269  274 ARG A CG  
1971 C CD  . ARG A 275 ? 0.70646 0.70985 0.72218 -0.14193 0.00054  0.01404  274 ARG A CD  
1972 N NE  . ARG A 275 ? 0.80084 0.80282 0.81435 -0.14985 0.00688  0.01942  274 ARG A NE  
1973 C CZ  . ARG A 275 ? 0.56262 0.57020 0.57610 -0.14366 0.01196  0.02371  274 ARG A CZ  
1974 N NH1 . ARG A 275 ? 0.45589 0.46901 0.47114 -0.12991 0.01135  0.02326  274 ARG A NH1 
1975 N NH2 . ARG A 275 ? 0.63769 0.64444 0.64833 -0.15195 0.01798  0.02853  274 ARG A NH2 
1976 N N   . PRO A 276 ? 0.35282 0.35871 0.36767 -0.10587 -0.00189 0.01358  275 PRO A N   
1977 C CA  . PRO A 276 ? 0.33543 0.33581 0.34565 -0.09702 0.00084  0.01684  275 PRO A CA  
1978 C C   . PRO A 276 ? 0.36971 0.34716 0.36672 -0.09898 0.00187  0.02003  275 PRO A C   
1979 O O   . PRO A 276 ? 0.33803 0.30482 0.32841 -0.09055 0.00090  0.02097  275 PRO A O   
1980 C CB  . PRO A 276 ? 0.37314 0.39437 0.39245 -0.09728 0.00586  0.01900  275 PRO A CB  
1981 C CG  . PRO A 276 ? 0.37064 0.41289 0.40222 -0.10001 0.00413  0.01598  275 PRO A CG  
1982 C CD  . PRO A 276 ? 0.36822 0.40083 0.39671 -0.10930 0.00000  0.01321  275 PRO A CD  
1983 N N   . SER A 277 ? 0.35158 0.32125 0.34431 -0.11004 0.00376  0.02200  276 SER A N   
1984 C CA  . SER A 277 ? 0.40283 0.34910 0.38118 -0.11120 0.00490  0.02593  276 SER A CA  
1985 C C   . SER A 277 ? 0.40570 0.32907 0.37346 -0.10681 -0.00004 0.02397  276 SER A C   
1986 O O   . SER A 277 ? 0.49097 0.39473 0.44627 -0.10412 0.00002  0.02721  276 SER A O   
1987 C CB  . SER A 277 ? 0.42109 0.36346 0.39649 -0.12497 0.00885  0.02917  276 SER A CB  
1988 O OG  . SER A 277 ? 0.45709 0.39930 0.43592 -0.13490 0.00635  0.02561  276 SER A OG  
1989 N N   . ASP A 278 ? 0.40868 0.33440 0.38042 -0.10521 -0.00424 0.01879  277 ASP A N   
1990 C CA  . ASP A 278 ? 0.38019 0.28652 0.34249 -0.09918 -0.00854 0.01623  277 ASP A CA  
1991 C C   . ASP A 278 ? 0.40534 0.31526 0.36879 -0.08549 -0.01006 0.01576  277 ASP A C   
1992 O O   . ASP A 278 ? 0.41809 0.31398 0.37425 -0.07887 -0.01306 0.01405  277 ASP A O   
1993 C CB  . ASP A 278 ? 0.36381 0.27101 0.32855 -0.10340 -0.01226 0.01038  277 ASP A CB  
1994 C CG  . ASP A 278 ? 0.45889 0.35437 0.41853 -0.11753 -0.01216 0.00980  277 ASP A CG  
1995 O OD1 . ASP A 278 ? 0.47177 0.35303 0.42325 -0.12331 -0.00921 0.01436  277 ASP A OD1 
1996 O OD2 . ASP A 278 ? 0.47508 0.37524 0.43822 -0.12319 -0.01520 0.00470  277 ASP A OD2 
1997 N N   . ARG A 279 ? 0.34070 0.26908 0.31307 -0.08124 -0.00796 0.01697  278 ARG A N   
1998 C CA  . ARG A 279 ? 0.32378 0.25605 0.29776 -0.07005 -0.00923 0.01645  278 ARG A CA  
1999 C C   . ARG A 279 ? 0.32731 0.24747 0.29239 -0.06532 -0.00885 0.02015  278 ARG A C   
2000 O O   . ARG A 279 ? 0.34066 0.25411 0.29987 -0.07020 -0.00644 0.02391  278 ARG A O   
2001 C CB  . ARG A 279 ? 0.30016 0.25391 0.28541 -0.06769 -0.00718 0.01619  278 ARG A CB  
2002 C CG  . ARG A 279 ? 0.27613 0.24318 0.26991 -0.07012 -0.00848 0.01263  278 ARG A CG  
2003 C CD  . ARG A 279 ? 0.29589 0.28319 0.29992 -0.06699 -0.00638 0.01282  278 ARG A CD  
2004 N NE  . ARG A 279 ? 0.26797 0.26858 0.27944 -0.07129 -0.00758 0.01033  278 ARG A NE  
2005 C CZ  . ARG A 279 ? 0.30634 0.32523 0.32683 -0.07283 -0.00535 0.01096  278 ARG A CZ  
2006 N NH1 . ARG A 279 ? 0.26439 0.28984 0.28721 -0.06957 -0.00135 0.01366  278 ARG A NH1 
2007 N NH2 . ARG A 279 ? 0.28075 0.31198 0.30773 -0.07755 -0.00732 0.00857  278 ARG A NH2 
2008 N N   . PRO A 280 ? 0.31646 0.23439 0.28016 -0.05597 -0.01124 0.01931  279 PRO A N   
2009 C CA  . PRO A 280 ? 0.31851 0.22757 0.27445 -0.05088 -0.01177 0.02261  279 PRO A CA  
2010 C C   . PRO A 280 ? 0.35835 0.27859 0.31742 -0.05089 -0.00912 0.02493  279 PRO A C   
2011 O O   . PRO A 280 ? 0.33002 0.26556 0.29829 -0.05145 -0.00730 0.02342  279 PRO A O   
2012 C CB  . PRO A 280 ? 0.32770 0.23692 0.28466 -0.04124 -0.01506 0.02025  279 PRO A CB  
2013 C CG  . PRO A 280 ? 0.32134 0.24542 0.28886 -0.04101 -0.01472 0.01664  279 PRO A CG  
2014 C CD  . PRO A 280 ? 0.29836 0.22276 0.26737 -0.04970 -0.01356 0.01545  279 PRO A CD  
2015 N N   . THR A 281 ? 0.35193 0.26321 0.30182 -0.04974 -0.00897 0.02862  280 THR A N   
2016 C CA  . THR A 281 ? 0.35613 0.27599 0.30658 -0.04759 -0.00755 0.03002  280 THR A CA  
2017 C C   . THR A 281 ? 0.36727 0.29376 0.32201 -0.03958 -0.01077 0.02773  280 THR A C   
2018 O O   . THR A 281 ? 0.32236 0.24575 0.27809 -0.03494 -0.01385 0.02602  280 THR A O   
2019 C CB  . THR A 281 ? 0.36901 0.27695 0.30667 -0.04830 -0.00702 0.03466  280 THR A CB  
2020 O OG1 . THR A 281 ? 0.37540 0.27053 0.30523 -0.04184 -0.01144 0.03565  280 THR A OG1 
2021 C CG2 . THR A 281 ? 0.40600 0.30641 0.33872 -0.05754 -0.00317 0.03759  280 THR A CG2 
2022 N N   . PHE A 282 ? 0.34284 0.27830 0.29961 -0.03815 -0.00987 0.02755  281 PHE A N   
2023 C CA  . PHE A 282 ? 0.35603 0.29749 0.31640 -0.03214 -0.01300 0.02559  281 PHE A CA  
2024 C C   . PHE A 282 ? 0.35284 0.28588 0.30627 -0.02668 -0.01734 0.02708  281 PHE A C   
2025 O O   . PHE A 282 ? 0.31490 0.25224 0.27298 -0.02149 -0.02024 0.02519  281 PHE A O   
2026 C CB  . PHE A 282 ? 0.32915 0.27814 0.28997 -0.03235 -0.01176 0.02500  281 PHE A CB  
2027 C CG  . PHE A 282 ? 0.41453 0.37193 0.38182 -0.03555 -0.00752 0.02343  281 PHE A CG  
2028 C CD1 . PHE A 282 ? 0.47355 0.43672 0.44953 -0.03587 -0.00665 0.02154  281 PHE A CD1 
2029 C CD2 . PHE A 282 ? 0.54921 0.50873 0.51286 -0.03730 -0.00442 0.02385  281 PHE A CD2 
2030 C CE1 . PHE A 282 ? 0.38370 0.35505 0.36523 -0.03742 -0.00307 0.02046  281 PHE A CE1 
2031 C CE2 . PHE A 282 ? 0.53413 0.50142 0.50335 -0.03863 -0.00039 0.02243  281 PHE A CE2 
2032 C CZ  . PHE A 282 ? 0.48270 0.45607 0.46116 -0.03846 0.00010  0.02092  281 PHE A CZ  
2033 N N   . GLU A 283 ? 0.32032 0.24196 0.26234 -0.02727 -0.01763 0.03078  282 GLU A N   
2034 C CA  . GLU A 283 ? 0.36876 0.28124 0.30274 -0.02074 -0.02202 0.03281  282 GLU A CA  
2035 C C   . GLU A 283 ? 0.36127 0.26621 0.29607 -0.01738 -0.02358 0.03166  282 GLU A C   
2036 O O   . GLU A 283 ? 0.34397 0.25028 0.27971 -0.00959 -0.02728 0.03077  282 GLU A O   
2037 C CB  . GLU A 283 ? 0.36913 0.26811 0.28861 -0.02233 -0.02145 0.03779  282 GLU A CB  
2038 C CG  . GLU A 283 ? 0.34651 0.23327 0.25558 -0.01466 -0.02602 0.04071  282 GLU A CG  
2039 C CD  . GLU A 283 ? 0.60104 0.47308 0.49390 -0.01623 -0.02517 0.04646  282 GLU A CD  
2040 O OE1 . GLU A 283 ? 0.53934 0.40718 0.42900 -0.02459 -0.02015 0.04833  282 GLU A OE1 
2041 O OE2 . GLU A 283 ? 0.53914 0.40472 0.42241 -0.00889 -0.02944 0.04934  282 GLU A OE2 
2042 N N   . GLU A 284 ? 0.33968 0.23742 0.27412 -0.02309 -0.02082 0.03129  283 GLU A N   
2043 C CA  . GLU A 284 ? 0.34858 0.23708 0.28187 -0.02025 -0.02231 0.02946  283 GLU A CA  
2044 C C   . GLU A 284 ? 0.33318 0.23553 0.27802 -0.01593 -0.02329 0.02502  283 GLU A C   
2045 O O   . GLU A 284 ? 0.33805 0.23641 0.28181 -0.00909 -0.02559 0.02343  283 GLU A O   
2046 C CB  . GLU A 284 ? 0.39960 0.27813 0.32994 -0.02895 -0.01950 0.02947  283 GLU A CB  
2047 C CG  . GLU A 284 ? 0.40074 0.26040 0.31701 -0.03308 -0.01843 0.03439  283 GLU A CG  
2048 C CD  . GLU A 284 ? 0.48726 0.34066 0.40277 -0.04413 -0.01517 0.03426  283 GLU A CD  
2049 O OE1 . GLU A 284 ? 0.40503 0.27406 0.33083 -0.05035 -0.01235 0.03259  283 GLU A OE1 
2050 O OE2 . GLU A 284 ? 0.49249 0.32546 0.39714 -0.04649 -0.01556 0.03571  283 GLU A OE2 
2051 N N   . ILE A 285 ? 0.30634 0.22434 0.26142 -0.01935 -0.02122 0.02317  284 ILE A N   
2052 C CA  . ILE A 285 ? 0.30168 0.23251 0.26673 -0.01559 -0.02169 0.01978  284 ILE A CA  
2053 C C   . ILE A 285 ? 0.31592 0.25244 0.28228 -0.00793 -0.02478 0.01991  284 ILE A C   
2054 O O   . ILE A 285 ? 0.30961 0.24882 0.27874 -0.00184 -0.02617 0.01805  284 ILE A O   
2055 C CB  . ILE A 285 ? 0.28961 0.23385 0.26347 -0.02029 -0.01883 0.01860  284 ILE A CB  
2056 C CG1 . ILE A 285 ? 0.28236 0.22511 0.25717 -0.02681 -0.01619 0.01806  284 ILE A CG1 
2057 C CG2 . ILE A 285 ? 0.28391 0.24052 0.26671 -0.01648 -0.01908 0.01609  284 ILE A CG2 
2058 C CD1 . ILE A 285 ? 0.30198 0.25690 0.28390 -0.03021 -0.01325 0.01765  284 ILE A CD1 
2059 N N   . GLN A 286 ? 0.26282 0.20286 0.22747 -0.00810 -0.02589 0.02183  285 GLN A N   
2060 C CA  . GLN A 286 ? 0.26652 0.21554 0.23408 -0.00174 -0.02939 0.02157  285 GLN A CA  
2061 C C   . GLN A 286 ? 0.32838 0.26821 0.28842 0.00651  -0.03294 0.02322  285 GLN A C   
2062 O O   . GLN A 286 ? 0.33931 0.28901 0.30389 0.01341  -0.03587 0.02241  285 GLN A O   
2063 C CB  . GLN A 286 ? 0.29325 0.24855 0.26013 -0.00450 -0.03028 0.02250  285 GLN A CB  
2064 C CG  . GLN A 286 ? 0.27503 0.24043 0.25004 -0.01042 -0.02717 0.02023  285 GLN A CG  
2065 C CD  . GLN A 286 ? 0.31674 0.28781 0.29056 -0.01256 -0.02848 0.02002  285 GLN A CD  
2066 O OE1 . GLN A 286 ? 0.32647 0.29071 0.29161 -0.01464 -0.02815 0.02185  285 GLN A OE1 
2067 N NE2 . GLN A 286 ? 0.30288 0.28628 0.28478 -0.01249 -0.02987 0.01767  285 GLN A NE2 
2068 N N   . ASN A 287 ? 0.30359 0.22498 0.25225 0.00610  -0.03265 0.02560  286 ASN A N   
2069 C CA  . ASN A 287 ? 0.32405 0.23301 0.26392 0.01489  -0.03567 0.02712  286 ASN A CA  
2070 C C   . ASN A 287 ? 0.38566 0.28881 0.32652 0.01837  -0.03476 0.02408  286 ASN A C   
2071 O O   . ASN A 287 ? 0.37044 0.26179 0.30345 0.02682  -0.03694 0.02469  286 ASN A O   
2072 C CB  . ASN A 287 ? 0.37595 0.26425 0.30041 0.01293  -0.03577 0.03169  286 ASN A CB  
2073 C CG  . ASN A 287 ? 0.45132 0.34323 0.37085 0.01367  -0.03801 0.03515  286 ASN A CG  
2074 O OD1 . ASN A 287 ? 0.41976 0.32604 0.34460 0.01935  -0.04156 0.03442  286 ASN A OD1 
2075 N ND2 . ASN A 287 ? 0.47954 0.35912 0.38866 0.00752  -0.03593 0.03883  286 ASN A ND2 
2076 N N   . HIS A 288 ? 0.33759 0.24801 0.28668 0.01283  -0.03173 0.02077  287 HIS A N   
2077 C CA  . HIS A 288 ? 0.36155 0.26628 0.31019 0.01567  -0.03091 0.01738  287 HIS A CA  
2078 C C   . HIS A 288 ? 0.34386 0.25820 0.29700 0.02688  -0.03267 0.01555  287 HIS A C   
2079 O O   . HIS A 288 ? 0.33340 0.26653 0.29624 0.02885  -0.03336 0.01562  287 HIS A O   
2080 C CB  . HIS A 288 ? 0.31860 0.23230 0.27544 0.00797  -0.02775 0.01451  287 HIS A CB  
2081 C CG  . HIS A 288 ? 0.32924 0.23484 0.28312 0.00889  -0.02705 0.01085  287 HIS A CG  
2082 N ND1 . HIS A 288 ? 0.32903 0.24192 0.28670 0.01636  -0.02700 0.00767  287 HIS A ND1 
2083 C CD2 . HIS A 288 ? 0.33260 0.22393 0.27972 0.00283  -0.02638 0.00955  287 HIS A CD2 
2084 C CE1 . HIS A 288 ? 0.32948 0.23186 0.28170 0.01546  -0.02647 0.00432  287 HIS A CE1 
2085 N NE2 . HIS A 288 ? 0.34397 0.23310 0.28994 0.00693  -0.02642 0.00523  287 HIS A NE2 
2086 N N   . PRO A 289 ? 0.35279 0.25476 0.29891 0.03427  -0.03327 0.01368  288 PRO A N   
2087 C CA  . PRO A 289 ? 0.38982 0.30270 0.34060 0.04615  -0.03434 0.01180  288 PRO A CA  
2088 C C   . PRO A 289 ? 0.37313 0.31057 0.33884 0.04480  -0.03205 0.00931  288 PRO A C   
2089 O O   . PRO A 289 ? 0.36412 0.31899 0.33809 0.05135  -0.03304 0.00939  288 PRO A O   
2090 C CB  . PRO A 289 ? 0.43302 0.32600 0.37269 0.05194  -0.03401 0.00898  288 PRO A CB  
2091 C CG  . PRO A 289 ? 0.54046 0.40855 0.46688 0.04504  -0.03448 0.01119  288 PRO A CG  
2092 C CD  . PRO A 289 ? 0.41789 0.29484 0.35087 0.03209  -0.03291 0.01302  288 PRO A CD  
2093 N N   . TRP A 290 ? 0.32143 0.26126 0.29076 0.03632  -0.02904 0.00738  289 TRP A N   
2094 C CA  . TRP A 290 ? 0.31594 0.27664 0.29756 0.03495  -0.02645 0.00571  289 TRP A CA  
2095 C C   . TRP A 290 ? 0.30483 0.28242 0.29622 0.03120  -0.02698 0.00802  289 TRP A C   
2096 O O   . TRP A 290 ? 0.32137 0.31710 0.32299 0.03196  -0.02544 0.00722  289 TRP A O   
2097 C CB  . TRP A 290 ? 0.29407 0.25270 0.27602 0.02711  -0.02363 0.00377  289 TRP A CB  
2098 C CG  . TRP A 290 ? 0.27882 0.25613 0.27098 0.02661  -0.02061 0.00257  289 TRP A CG  
2099 C CD1 . TRP A 290 ? 0.29373 0.27869 0.28797 0.03335  -0.01876 0.00017  289 TRP A CD1 
2100 C CD2 . TRP A 290 ? 0.24900 0.23853 0.24951 0.01927  -0.01876 0.00411  289 TRP A CD2 
2101 N NE1 . TRP A 290 ? 0.28949 0.29084 0.29287 0.02978  -0.01563 0.00057  289 TRP A NE1 
2102 C CE2 . TRP A 290 ? 0.28829 0.29161 0.29534 0.02123  -0.01577 0.00298  289 TRP A CE2 
2103 C CE3 . TRP A 290 ? 0.25754 0.24665 0.25960 0.01156  -0.01900 0.00632  289 TRP A CE3 
2104 C CZ2 . TRP A 290 ? 0.28621 0.30093 0.30064 0.01533  -0.01320 0.00433  289 TRP A CZ2 
2105 C CZ3 . TRP A 290 ? 0.25010 0.25062 0.25957 0.00656  -0.01661 0.00707  289 TRP A CZ3 
2106 C CH2 . TRP A 290 ? 0.23974 0.25198 0.25502 0.00825  -0.01383 0.00625  289 TRP A CH2 
2107 N N   . MET A 291 ? 0.29353 0.26518 0.28126 0.02682  -0.02896 0.01074  290 MET A N   
2108 C CA  . MET A 291 ? 0.30102 0.28625 0.29610 0.02202  -0.02954 0.01215  290 MET A CA  
2109 C C   . MET A 291 ? 0.33954 0.33523 0.33758 0.02861  -0.03332 0.01320  290 MET A C   
2110 O O   . MET A 291 ? 0.33020 0.33701 0.33353 0.02451  -0.03465 0.01387  290 MET A O   
2111 C CB  . MET A 291 ? 0.27695 0.25203 0.26614 0.01410  -0.02946 0.01417  290 MET A CB  
2112 C CG  . MET A 291 ? 0.33243 0.30344 0.32208 0.00675  -0.02581 0.01313  290 MET A CG  
2113 S SD  . MET A 291 ? 0.43511 0.42094 0.43450 -0.00010 -0.02333 0.01277  290 MET A SD  
2114 C CE  . MET A 291 ? 0.60523 0.58598 0.59886 -0.00371 -0.02513 0.01510  290 MET A CE  
2115 N N   . GLN A 292 ? 0.33002 0.32235 0.32429 0.03897  -0.03537 0.01314  291 GLN A N   
2116 C CA  . GLN A 292 ? 0.37334 0.37561 0.36953 0.04623  -0.03980 0.01458  291 GLN A CA  
2117 C C   . GLN A 292 ? 0.37799 0.40658 0.38925 0.04825  -0.03932 0.01273  291 GLN A C   
2118 O O   . GLN A 292 ? 0.31776 0.35388 0.33566 0.04716  -0.03521 0.01055  291 GLN A O   
2119 C CB  . GLN A 292 ? 0.41575 0.40276 0.40079 0.05771  -0.04230 0.01573  291 GLN A CB  
2120 C CG  . GLN A 292 ? 0.50046 0.46026 0.47002 0.05368  -0.04234 0.01807  291 GLN A CG  
2121 C CD  . GLN A 292 ? 0.57188 0.53109 0.53945 0.04429  -0.04325 0.02069  291 GLN A CD  
2122 O OE1 . GLN A 292 ? 0.56224 0.52922 0.52980 0.04695  -0.04714 0.02266  291 GLN A OE1 
2123 N NE2 . GLN A 292 ? 0.36655 0.31741 0.33219 0.03377  -0.03973 0.02046  291 GLN A NE2 
2124 N N   . ASP A 293 ? 0.32524 0.36852 0.34164 0.05034  -0.04360 0.01373  292 ASP A N   
2125 C CA  . ASP A 293 ? 0.37154 0.44238 0.40315 0.05167  -0.04396 0.01223  292 ASP A CA  
2126 C C   . ASP A 293 ? 0.33802 0.41938 0.37933 0.03960  -0.03976 0.01071  292 ASP A C   
2127 O O   . ASP A 293 ? 0.29076 0.38845 0.34275 0.03965  -0.03650 0.00927  292 ASP A O   
2128 C CB  . ASP A 293 ? 0.40314 0.48182 0.43848 0.06374  -0.04261 0.01095  292 ASP A CB  
2129 C CG  . ASP A 293 ? 0.56083 0.63150 0.58740 0.07733  -0.04732 0.01258  292 ASP A CG  
2130 O OD1 . ASP A 293 ? 0.62966 0.70686 0.65610 0.07920  -0.05286 0.01447  292 ASP A OD1 
2131 O OD2 . ASP A 293 ? 0.67250 0.72905 0.69104 0.08631  -0.04569 0.01192  292 ASP A OD2 
2132 N N   . VAL A 294 ? 0.26930 0.34123 0.30633 0.02955  -0.03960 0.01127  293 VAL A N   
2133 C CA  . VAL A 294 ? 0.22300 0.30089 0.26684 0.01871  -0.03562 0.01014  293 VAL A CA  
2134 C C   . VAL A 294 ? 0.24272 0.34427 0.29940 0.01504  -0.03717 0.00906  293 VAL A C   
2135 O O   . VAL A 294 ? 0.27218 0.38398 0.33099 0.01780  -0.04264 0.00912  293 VAL A O   
2136 C CB  . VAL A 294 ? 0.25551 0.31754 0.29093 0.01041  -0.03525 0.01081  293 VAL A CB  
2137 C CG1 . VAL A 294 ? 0.26486 0.32892 0.29714 0.00893  -0.04061 0.01129  293 VAL A CG1 
2138 C CG2 . VAL A 294 ? 0.28214 0.34630 0.32244 0.00096  -0.03064 0.00986  293 VAL A CG2 
2139 N N   . LEU A 295 ? 0.23931 0.35012 0.30444 0.00863  -0.03244 0.00819  294 LEU A N   
2140 C CA  . LEU A 295 ? 0.24732 0.37904 0.32455 0.00194  -0.03308 0.00714  294 LEU A CA  
2141 C C   . LEU A 295 ? 0.24234 0.36818 0.31595 -0.00789 -0.03580 0.00643  294 LEU A C   
2142 O O   . LEU A 295 ? 0.26878 0.37545 0.33250 -0.01149 -0.03436 0.00684  294 LEU A O   
2143 C CB  . LEU A 295 ? 0.19731 0.33685 0.28231 -0.00354 -0.02641 0.00707  294 LEU A CB  
2144 C CG  . LEU A 295 ? 0.24825 0.39730 0.33810 0.00457  -0.02233 0.00727  294 LEU A CG  
2145 C CD1 . LEU A 295 ? 0.29416 0.44798 0.38908 -0.00319 -0.01545 0.00786  294 LEU A CD1 
2146 C CD2 . LEU A 295 ? 0.26995 0.44255 0.37022 0.01195  -0.02549 0.00662  294 LEU A CD2 
2147 N N   . LEU A 296 ? 0.23193 0.37551 0.31391 -0.01244 -0.03957 0.00499  295 LEU A N   
2148 C CA  . LEU A 296 ? 0.25269 0.39194 0.33181 -0.02322 -0.04162 0.00333  295 LEU A CA  
2149 C C   . LEU A 296 ? 0.25436 0.38881 0.33584 -0.03365 -0.03535 0.00297  295 LEU A C   
2150 O O   . LEU A 296 ? 0.24909 0.39142 0.33798 -0.03364 -0.03033 0.00396  295 LEU A O   
2151 C CB  . LEU A 296 ? 0.25056 0.41149 0.33826 -0.02582 -0.04801 0.00134  295 LEU A CB  
2152 C CG  . LEU A 296 ? 0.33172 0.50251 0.41891 -0.01458 -0.05505 0.00198  295 LEU A CG  
2153 C CD1 . LEU A 296 ? 0.33629 0.53086 0.43307 -0.01925 -0.06160 -0.00047 295 LEU A CD1 
2154 C CD2 . LEU A 296 ? 0.29109 0.43941 0.36144 -0.00899 -0.05789 0.00352  295 LEU A CD2 
2155 N N   . PRO A 297 ? 0.30253 0.42330 0.37671 -0.04212 -0.03530 0.00168  296 PRO A N   
2156 C CA  . PRO A 297 ? 0.28772 0.40191 0.36281 -0.05148 -0.02942 0.00164  296 PRO A CA  
2157 C C   . PRO A 297 ? 0.29618 0.43019 0.38463 -0.05875 -0.02788 0.00107  296 PRO A C   
2158 O O   . PRO A 297 ? 0.25250 0.38689 0.34456 -0.06110 -0.02159 0.00293  296 PRO A O   
2159 C CB  . PRO A 297 ? 0.31352 0.41159 0.37820 -0.05816 -0.03118 -0.00050 296 PRO A CB  
2160 C CG  . PRO A 297 ? 0.32051 0.41038 0.37574 -0.04991 -0.03535 -0.00015 296 PRO A CG  
2161 C CD  . PRO A 297 ? 0.30880 0.41727 0.37175 -0.04259 -0.03987 0.00044  296 PRO A CD  
2162 N N   . GLN A 298 ? 0.26752 0.41936 0.36353 -0.06248 -0.03350 -0.00129 297 GLN A N   
2163 C CA  . GLN A 298 ? 0.23828 0.41175 0.34853 -0.07084 -0.03205 -0.00194 297 GLN A CA  
2164 C C   . GLN A 298 ? 0.32370 0.51413 0.44432 -0.06324 -0.02793 0.00061  297 GLN A C   
2165 O O   . GLN A 298 ? 0.30473 0.50304 0.43276 -0.06950 -0.02194 0.00192  297 GLN A O   
2166 C CB  . GLN A 298 ? 0.37223 0.56449 0.48931 -0.07547 -0.04003 -0.00533 297 GLN A CB  
2167 N N   . GLU A 299 ? 0.27420 0.46935 0.39430 -0.04958 -0.03074 0.00140  298 GLU A N   
2168 C CA  . GLU A 299 ? 0.30350 0.51116 0.43067 -0.04057 -0.02649 0.00331  298 GLU A CA  
2169 C C   . GLU A 299 ? 0.29190 0.48241 0.41228 -0.04084 -0.01863 0.00554  298 GLU A C   
2170 O O   . GLU A 299 ? 0.24527 0.44690 0.37256 -0.04065 -0.01276 0.00698  298 GLU A O   
2171 C CB  . GLU A 299 ? 0.26164 0.47019 0.38538 -0.02522 -0.03098 0.00358  298 GLU A CB  
2172 C CG  . GLU A 299 ? 0.27356 0.50199 0.40422 -0.02168 -0.03907 0.00205  298 GLU A CG  
2173 C CD  . GLU A 299 ? 0.30037 0.52106 0.42250 -0.00658 -0.04375 0.00298  298 GLU A CD  
2174 O OE1 . GLU A 299 ? 0.25543 0.45150 0.36450 -0.00184 -0.04154 0.00431  298 GLU A OE1 
2175 O OE2 . GLU A 299 ? 0.37229 0.61121 0.50035 0.00030  -0.04985 0.00249  298 GLU A OE2 
2176 N N   . THR A 300 ? 0.21765 0.38228 0.32433 -0.04068 -0.01845 0.00594  299 THR A N   
2177 C CA  . THR A 300 ? 0.25672 0.40564 0.35649 -0.04046 -0.01195 0.00799  299 THR A CA  
2178 C C   . THR A 300 ? 0.27482 0.42650 0.37888 -0.05172 -0.00627 0.00919  299 THR A C   
2179 O O   . THR A 300 ? 0.25592 0.40941 0.36103 -0.05060 -0.00015 0.01140  299 THR A O   
2180 C CB  . THR A 300 ? 0.24502 0.36869 0.33092 -0.03943 -0.01324 0.00800  299 THR A CB  
2181 O OG1 . THR A 300 ? 0.24320 0.36297 0.32423 -0.02970 -0.01783 0.00750  299 THR A OG1 
2182 C CG2 . THR A 300 ? 0.24095 0.35062 0.32032 -0.03863 -0.00728 0.01006  299 THR A CG2 
2183 N N   . ALA A 301 ? 0.26484 0.41597 0.37029 -0.06285 -0.00820 0.00775  300 ALA A N   
2184 C CA  . ALA A 301 ? 0.27858 0.42967 0.38688 -0.07485 -0.00288 0.00900  300 ALA A CA  
2185 C C   . ALA A 301 ? 0.31659 0.49408 0.43932 -0.07693 0.00060  0.01015  300 ALA A C   
2186 O O   . ALA A 301 ? 0.31631 0.49361 0.43971 -0.08051 0.00778  0.01312  300 ALA A O   
2187 C CB  . ALA A 301 ? 0.32769 0.47217 0.43385 -0.08656 -0.00646 0.00628  300 ALA A CB  
2188 N N   . GLU A 302 ? 0.30409 0.50550 0.43837 -0.07432 -0.00427 0.00807  301 GLU A N   
2189 C CA  . GLU A 302 ? 0.31396 0.54441 0.46397 -0.07699 -0.00097 0.00885  301 GLU A CA  
2190 C C   . GLU A 302 ? 0.31008 0.54596 0.46072 -0.06589 0.00498  0.01138  301 GLU A C   
2191 O O   . GLU A 302 ? 0.28780 0.53671 0.44548 -0.07020 0.01192  0.01363  301 GLU A O   
2192 C CB  . GLU A 302 ? 0.28961 0.54593 0.45200 -0.07531 -0.00839 0.00587  301 GLU A CB  
2193 C CG  . GLU A 302 ? 0.35266 0.60840 0.51625 -0.08920 -0.01368 0.00292  301 GLU A CG  
2194 C CD  . GLU A 302 ? 0.53864 0.81682 0.71127 -0.08602 -0.02285 -0.00029 301 GLU A CD  
2195 O OE1 . GLU A 302 ? 0.53084 0.82261 0.70767 -0.07166 -0.02526 0.00014  301 GLU A OE1 
2196 O OE2 . GLU A 302 ? 0.45372 0.73498 0.62821 -0.09762 -0.02788 -0.00335 301 GLU A OE2 
2197 N N   . ILE A 303 ? 0.27239 0.49714 0.41456 -0.05216 0.00267  0.01099  302 ILE A N   
2198 C CA  . ILE A 303 ? 0.26987 0.49847 0.41107 -0.04088 0.00753  0.01236  302 ILE A CA  
2199 C C   . ILE A 303 ? 0.31818 0.52691 0.44838 -0.04311 0.01419  0.01508  302 ILE A C   
2200 O O   . ILE A 303 ? 0.29851 0.51553 0.43064 -0.04114 0.02091  0.01705  302 ILE A O   
2201 C CB  . ILE A 303 ? 0.28932 0.51215 0.42478 -0.02598 0.00218  0.01058  302 ILE A CB  
2202 C CG1 . ILE A 303 ? 0.26222 0.50753 0.40875 -0.02159 -0.00410 0.00858  302 ILE A CG1 
2203 C CG2 . ILE A 303 ? 0.28176 0.50298 0.41287 -0.01471 0.00708  0.01124  302 ILE A CG2 
2204 C CD1 . ILE A 303 ? 0.37677 0.61167 0.51520 -0.00846 -0.01037 0.00732  302 ILE A CD1 
2205 N N   . HIS A 304 ? 0.26435 0.44750 0.38244 -0.04641 0.01252  0.01531  303 HIS A N   
2206 C CA  . HIS A 304 ? 0.28944 0.45299 0.39563 -0.04480 0.01717  0.01763  303 HIS A CA  
2207 C C   . HIS A 304 ? 0.31939 0.46898 0.42041 -0.05636 0.02084  0.02009  303 HIS A C   
2208 O O   . HIS A 304 ? 0.34373 0.48206 0.43663 -0.05537 0.02586  0.02292  303 HIS A O   
2209 C CB  . HIS A 304 ? 0.25767 0.40181 0.35258 -0.03642 0.01275  0.01619  303 HIS A CB  
2210 C CG  . HIS A 304 ? 0.27521 0.42587 0.37076 -0.02398 0.01011  0.01427  303 HIS A CG  
2211 N ND1 . HIS A 304 ? 0.29575 0.44815 0.38833 -0.01589 0.01401  0.01459  303 HIS A ND1 
2212 C CD2 . HIS A 304 ? 0.25342 0.40730 0.35061 -0.01786 0.00396  0.01203  303 HIS A CD2 
2213 C CE1 . HIS A 304 ? 0.26896 0.42442 0.36136 -0.00539 0.01047  0.01229  303 HIS A CE1 
2214 N NE2 . HIS A 304 ? 0.27584 0.43207 0.37098 -0.00621 0.00440  0.01108  303 HIS A NE2 
2215 N N   . LEU A 305 ? 0.29251 0.44104 0.39655 -0.06677 0.01827  0.01901  304 LEU A N   
2216 C CA  . LEU A 305 ? 0.31952 0.44937 0.41580 -0.07679 0.02119  0.02089  304 LEU A CA  
2217 C C   . LEU A 305 ? 0.46053 0.60051 0.56453 -0.09036 0.02517  0.02230  304 LEU A C   
2218 O O   . LEU A 305 ? 0.47204 0.59732 0.56890 -0.09735 0.03038  0.02548  304 LEU A O   
2219 C CB  . LEU A 305 ? 0.34892 0.46146 0.43782 -0.07853 0.01539  0.01812  304 LEU A CB  
2220 C CG  . LEU A 305 ? 0.30072 0.40390 0.38260 -0.06689 0.01125  0.01671  304 LEU A CG  
2221 C CD1 . LEU A 305 ? 0.31588 0.40442 0.39092 -0.06917 0.00617  0.01407  304 LEU A CD1 
2222 C CD2 . LEU A 305 ? 0.29223 0.38270 0.36511 -0.06031 0.01549  0.01955  304 LEU A CD2 
2223 N N   . HIS A 306 ? 0.41501 0.57947 0.53313 -0.09448 0.02278  0.02016  305 HIS A N   
2224 C CA  . HIS A 306 ? 0.47932 0.65542 0.60614 -0.10920 0.02639  0.02121  305 HIS A CA  
2225 C C   . HIS A 306 ? 0.44954 0.63842 0.58080 -0.10916 0.03520  0.02565  305 HIS A C   
2226 O O   . HIS A 306 ? 0.63151 0.81015 0.75793 -0.11862 0.04170  0.02946  305 HIS A O   
2227 C CB  . HIS A 306 ? 0.41265 0.61395 0.55435 -0.11400 0.02031  0.01719  305 HIS A CB  
2228 C CG  . HIS A 306 ? 0.51493 0.70394 0.65148 -0.11746 0.01221  0.01290  305 HIS A CG  
2229 N ND1 . HIS A 306 ? 0.42571 0.63468 0.57291 -0.12070 0.00505  0.00884  305 HIS A ND1 
2230 C CD2 . HIS A 306 ? 0.47296 0.63271 0.59440 -0.11758 0.01022  0.01197  305 HIS A CD2 
2231 C CE1 . HIS A 306 ? 0.43537 0.62672 0.57311 -0.12297 -0.00098 0.00554  305 HIS A CE1 
2232 N NE2 . HIS A 306 ? 0.42019 0.58174 0.54251 -0.12109 0.00236  0.00732  305 HIS A NE2 
2233 N N   . ARG B 2   ? 0.78672 0.86952 0.73262 -0.04572 -0.03368 -0.01056 2   ARG B N   
2234 C CA  . ARG B 2   ? 0.87017 0.95978 0.82186 -0.03586 -0.02994 0.00346  2   ARG B CA  
2235 C C   . ARG B 2   ? 0.82936 0.88914 0.76904 -0.02246 -0.02445 0.01279  2   ARG B C   
2236 O O   . ARG B 2   ? 0.77178 0.80435 0.70003 -0.02103 -0.02311 0.00709  2   ARG B O   
2237 C CB  . ARG B 2   ? 0.75270 0.85249 0.71889 -0.03739 -0.02873 -0.00058 2   ARG B CB  
2238 C CG  . ARG B 2   ? 0.64921 0.72162 0.61229 -0.03556 -0.02590 -0.00932 2   ARG B CG  
2239 C CD  . ARG B 2   ? 0.58625 0.66992 0.56336 -0.03915 -0.02551 -0.01432 2   ARG B CD  
2240 N NE  . ARG B 2   ? 0.48463 0.59301 0.47197 -0.05222 -0.03130 -0.02489 2   ARG B NE  
2241 C CZ  . ARG B 2   ? 0.52359 0.62546 0.50952 -0.06103 -0.03514 -0.03963 2   ARG B CZ  
2242 N NH1 . ARG B 2   ? 0.51422 0.58553 0.48887 -0.05847 -0.03399 -0.04594 2   ARG B NH1 
2243 N NH2 . ARG B 2   ? 0.41534 0.54232 0.41167 -0.07260 -0.04039 -0.04859 2   ARG B NH2 
2244 N N   . LYS B 3   ? 0.69782 0.76300 0.64048 -0.01254 -0.02132 0.02667  3   LYS B N   
2245 C CA  . LYS B 3   ? 0.56545 0.60594 0.49664 0.00028  -0.01677 0.03697  3   LYS B CA  
2246 C C   . LYS B 3   ? 0.56132 0.57707 0.49149 0.00729  -0.01123 0.03439  3   LYS B C   
2247 O O   . LYS B 3   ? 0.68962 0.71363 0.63054 0.00988  -0.00866 0.03611  3   LYS B O   
2248 C CB  . LYS B 3   ? 0.50873 0.56484 0.44359 0.00854  -0.01605 0.05253  3   LYS B CB  
2249 N N   . ARG B 4   ? 0.44473 0.43035 0.36162 0.01026  -0.00931 0.03048  4   ARG B N   
2250 C CA  . ARG B 4   ? 0.39030 0.34910 0.30334 0.01842  -0.00375 0.02978  4   ARG B CA  
2251 C C   . ARG B 4   ? 0.43665 0.38202 0.34257 0.03216  0.00083  0.04366  4   ARG B C   
2252 O O   . ARG B 4   ? 0.45513 0.39643 0.35170 0.03473  -0.00043 0.04976  4   ARG B O   
2253 C CB  . ARG B 4   ? 0.41469 0.34820 0.31733 0.01418  -0.00443 0.01737  4   ARG B CB  
2254 C CG  . ARG B 4   ? 0.37112 0.27236 0.26585 0.02304  0.00109  0.01693  4   ARG B CG  
2255 C CD  . ARG B 4   ? 0.36945 0.24983 0.25510 0.01720  -0.00087 0.00331  4   ARG B CD  
2256 N NE  . ARG B 4   ? 0.37738 0.22440 0.25196 0.02611  0.00405  0.00368  4   ARG B NE  
2257 C CZ  . ARG B 4   ? 0.43471 0.26834 0.31161 0.02952  0.00746  0.00099  4   ARG B CZ  
2258 N NH1 . ARG B 4   ? 0.39387 0.24387 0.28357 0.02522  0.00680  -0.00153 4   ARG B NH1 
2259 N NH2 . ARG B 4   ? 0.39358 0.19650 0.25932 0.03688  0.01151  0.00050  4   ARG B NH2 
2260 N N   . ARG B 5   ? 0.39187 0.33133 0.30245 0.04080  0.00603  0.04878  5   ARG B N   
2261 C CA  . ARG B 5   ? 0.40489 0.33366 0.31045 0.05431  0.01039  0.06177  5   ARG B CA  
2262 C C   . ARG B 5   ? 0.41200 0.31698 0.31512 0.06251  0.01678  0.06136  5   ARG B C   
2263 O O   . ARG B 5   ? 0.38838 0.29198 0.29724 0.05828  0.01800  0.05352  5   ARG B O   
2264 C CB  . ARG B 5   ? 0.41308 0.37007 0.32996 0.05816  0.00981  0.07296  5   ARG B CB  
2265 C CG  . ARG B 5   ? 0.47953 0.45397 0.41159 0.05729  0.01195  0.07198  5   ARG B CG  
2266 C CD  . ARG B 5   ? 0.60775 0.61167 0.55081 0.06089  0.01077  0.08280  5   ARG B CD  
2267 N NE  . ARG B 5   ? 0.67705 0.69370 0.63308 0.06391  0.01452  0.08468  5   ARG B NE  
2268 C CZ  . ARG B 5   ? 0.65878 0.66509 0.61508 0.07550  0.02033  0.09165  5   ARG B CZ  
2269 N NH1 . ARG B 5   ? 0.55643 0.53822 0.50087 0.08583  0.02322  0.09744  5   ARG B NH1 
2270 N N   . ARG B 6   ? 0.40583 0.29166 0.29993 0.07424  0.02074  0.06998  6   ARG B N   
2271 C CA  . ARG B 6   ? 0.41063 0.27802 0.30377 0.08376  0.02732  0.07234  6   ARG B CA  
2272 C C   . ARG B 6   ? 0.42545 0.31525 0.33290 0.08795  0.02973  0.07942  6   ARG B C   
2273 O O   . ARG B 6   ? 0.40603 0.32307 0.32237 0.08602  0.02647  0.08470  6   ARG B O   
2274 C CB  . ARG B 6   ? 0.46322 0.30529 0.34312 0.09523  0.03067  0.07969  6   ARG B CB  
2275 C CG  . ARG B 6   ? 0.46199 0.27910 0.32693 0.09178  0.02920  0.07237  6   ARG B CG  
2276 C CD  . ARG B 6   ? 0.53771 0.33089 0.38982 0.10325  0.03249  0.08041  6   ARG B CD  
2277 N NE  . ARG B 6   ? 0.49101 0.25887 0.32882 0.10028  0.03185  0.07285  6   ARG B NE  
2278 C CZ  . ARG B 6   ? 0.56065 0.30158 0.39097 0.10344  0.03581  0.06705  6   ARG B CZ  
2279 N NH1 . ARG B 6   ? 0.53239 0.27005 0.36899 0.10828  0.04053  0.06718  6   ARG B NH1 
2280 N NH2 . ARG B 6   ? 0.54815 0.27279 0.36831 0.09864  0.03428  0.05882  6   ARG B NH2 
2281 N N   . HIS B 7   ? 0.41062 0.28917 0.32010 0.09332  0.03539  0.07913  7   HIS B N   
2282 C CA  . HIS B 7   ? 0.41082 0.30860 0.33346 0.09748  0.03859  0.08499  7   HIS B CA  
2283 C C   . HIS B 7   ? 0.45144 0.32967 0.36951 0.11060  0.04554  0.09142  7   HIS B C   
2284 O O   . HIS B 7   ? 0.49439 0.35053 0.40697 0.11125  0.04948  0.08585  7   HIS B O   
2285 C CB  . HIS B 7   ? 0.39927 0.30801 0.33168 0.08775  0.03841  0.07612  7   HIS B CB  
2286 C CG  . HIS B 7   ? 0.40329 0.33121 0.34100 0.07461  0.03170  0.06867  7   HIS B CG  
2287 N ND1 . HIS B 7   ? 0.38802 0.30229 0.31785 0.06626  0.02805  0.05817  7   HIS B ND1 
2288 C CD2 . HIS B 7   ? 0.38197 0.34225 0.33240 0.06836  0.02797  0.06978  7   HIS B CD2 
2289 C CE1 . HIS B 7   ? 0.42295 0.36050 0.36051 0.05543  0.02238  0.05306  7   HIS B CE1 
2290 N NE2 . HIS B 7   ? 0.37427 0.33983 0.32423 0.05637  0.02225  0.06005  7   HIS B NE2 
2291 N N   . PRO B 8   ? 0.49317 0.37881 0.41346 0.12106  0.04705  0.10265  8   PRO B N   
2292 C CA  . PRO B 8   ? 0.52783 0.39516 0.44399 0.13397  0.05362  0.10851  8   PRO B CA  
2293 C C   . PRO B 8   ? 0.55311 0.42163 0.47676 0.13435  0.05916  0.10561  8   PRO B C   
2294 O O   . PRO B 8   ? 0.54220 0.43355 0.47798 0.12731  0.05824  0.10292  8   PRO B O   
2295 C CB  . PRO B 8   ? 0.58170 0.46511 0.50276 0.14348  0.05276  0.12063  8   PRO B CB  
2296 C CG  . PRO B 8   ? 0.60404 0.49942 0.52298 0.13666  0.04549  0.12115  8   PRO B CG  
2297 C CD  . PRO B 8   ? 0.54453 0.45131 0.46834 0.12192  0.04215  0.11030  8   PRO B CD  
2298 N N   . SER B 9   ? 0.54175 0.38454 0.45736 0.14226  0.06501  0.10594  9   SER B N   
2299 C CA  . SER B 9   ? 0.56686 0.40744 0.48753 0.14503  0.07135  0.10499  9   SER B CA  
2300 C C   . SER B 9   ? 0.78989 0.61891 0.70757 0.15972  0.07712  0.11331  9   SER B C   
2301 O O   . SER B 9   ? 0.82675 0.65303 0.74030 0.16763  0.07562  0.12041  9   SER B O   
2302 C CB  . SER B 9   ? 0.63985 0.45729 0.55252 0.13833  0.07288  0.09474  9   SER B CB  
2303 O OG  . SER B 9   ? 0.68003 0.46783 0.57742 0.14196  0.07294  0.09297  9   SER B OG  
2304 N N   . GLY B 10  ? 0.78929 0.61055 0.70845 0.16323  0.08362  0.11223  10  GLY B N   
2305 C CA  . GLY B 10  ? 0.75924 0.57459 0.67714 0.17134  0.08798  0.11496  10  GLY B CA  
2306 C C   . GLY B 10  ? 0.82234 0.65635 0.74870 0.18219  0.08817  0.12587  10  GLY B C   
2307 O O   . GLY B 10  ? 0.85353 0.70259 0.79080 0.18950  0.09258  0.13188  10  GLY B O   
# 
