data_8QVR
# 
_entry.id   8QVR 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8QVR         pdb_00008qvr 10.2210/pdb8qvr/pdb 
WWPDB D_1292133473 ?            ?                   
EMDB  EMD-18673    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-06-04 ? 
2 'EM metadata'     1 0 2025-06-04 ? 
3 FSC               1 0 2025-06-04 ? 
4 'Half map'        1 0 2025-06-04 1 
5 'Half map'        1 0 2025-06-04 2 
6 Image             1 0 2025-06-04 ? 
7 'Primary map'     1 0 2025-06-04 ? 
# 
loop_
_pdbx_audit_revision_details.ordinal 
_pdbx_audit_revision_details.revision_ordinal 
_pdbx_audit_revision_details.data_content_type 
_pdbx_audit_revision_details.provider 
_pdbx_audit_revision_details.type 
_pdbx_audit_revision_details.description 
_pdbx_audit_revision_details.details 
1 1 'Structure model' repository 'Initial release' ? ? 
2 2 'EM metadata'     repository 'Initial release' ? ? 
3 3 FSC               repository 'Initial release' ? ? 
4 4 'Half map'        repository 'Initial release' ? ? 
5 5 'Half map'        repository 'Initial release' ? ? 
6 6 Image             repository 'Initial release' ? ? 
7 7 'Primary map'     repository 'Initial release' ? ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8QVR 
_pdbx_database_status.recvd_initial_deposition_date   2023-10-18 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.details 
_pdbx_database_related.db_id 
_pdbx_database_related.content_type 
PDB  .                                                                                       8QJ1      unspecified            
PDB  .                                                                                       8QVP      unspecified            
PDB  .                                                                                       8QVQ      unspecified            
EMDB 'Cryo-EM structure of human islet amyloid polypeptide (hIAPP) mutant S29P, polymorph 3' EMD-18673 'associated EM volume' 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              michal.maj@kemi.uu.se 
_pdbx_contact_author.name_first         Michal 
_pdbx_contact_author.name_last          Maj 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-1567-9514 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Ooi, S.A.' 1 0000-0002-7858-4208 
'Valli, D.' 2 0009-0005-6060-4169 
'Maj, M.'   3 0000-0003-1567-9514 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Cryo-EM structure of human islet amyloid polypeptide (hIAPP) mutant S29P, polymorph 3' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Ooi, S.A.' 1 0000-0002-7858-4208 
primary 'Valli, D.' 2 0009-0005-6060-4169 
primary 'Maj, M.'   3 0000-0003-1567-9514 
# 
_entity.id                         1 
_entity.type                       polymer 
_entity.src_method                 syn 
_entity.pdbx_description           'Islet amyloid polypeptide' 
_entity.formula_weight             3917.349 
_entity.pdbx_number_of_molecules   10 
_entity.pdbx_ec                    ? 
_entity.pdbx_mutation              S29P 
_entity.pdbx_fragment              ? 
_entity.details                    ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Amylin,Diabetes-associated peptide,DAP,Insulinoma amyloid peptide' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   yes 
_entity_poly.pdbx_seq_one_letter_code       'KCNTATCATQRLANFLVHSSNNFGAILSPTNVGSNTY(NH2)' 
_entity_poly.pdbx_seq_one_letter_code_can   KCNTATCATQRLANFLVHSSNNFGAILSPTNVGSNTYX 
_entity_poly.pdbx_strand_id                 A,B,C,D,E,F,G,H,I,J 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1  LYS n 
1 2  CYS n 
1 3  ASN n 
1 4  THR n 
1 5  ALA n 
1 6  THR n 
1 7  CYS n 
1 8  ALA n 
1 9  THR n 
1 10 GLN n 
1 11 ARG n 
1 12 LEU n 
1 13 ALA n 
1 14 ASN n 
1 15 PHE n 
1 16 LEU n 
1 17 VAL n 
1 18 HIS n 
1 19 SER n 
1 20 SER n 
1 21 ASN n 
1 22 ASN n 
1 23 PHE n 
1 24 GLY n 
1 25 ALA n 
1 26 ILE n 
1 27 LEU n 
1 28 SER n 
1 29 PRO n 
1 30 THR n 
1 31 ASN n 
1 32 VAL n 
1 33 GLY n 
1 34 SER n 
1 35 ASN n 
1 36 THR n 
1 37 TYR n 
1 38 NH2 n 
# 
_pdbx_entity_src_syn.entity_id              1 
_pdbx_entity_src_syn.pdbx_src_id            1 
_pdbx_entity_src_syn.pdbx_alt_source_flag   sample 
_pdbx_entity_src_syn.pdbx_beg_seq_num       1 
_pdbx_entity_src_syn.pdbx_end_seq_num       38 
_pdbx_entity_src_syn.organism_scientific    'Homo sapiens' 
_pdbx_entity_src_syn.organism_common_name   human 
_pdbx_entity_src_syn.ncbi_taxonomy_id       9606 
_pdbx_entity_src_syn.details                ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE       ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE      ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE    ? 'C4 H8 N2 O3'    132.118 
CYS 'L-peptide linking' y CYSTEINE      ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE     ? 'C5 H10 N2 O3'   146.144 
GLY 'peptide linking'   y GLYCINE       ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE     ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE    ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE       ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE        ? 'C6 H15 N2 O2 1' 147.195 
NH2 non-polymer         . 'AMINO GROUP' ? 'H2 N'           16.023  
PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE       ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE        ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE     ? 'C4 H9 N O3'     119.119 
TYR 'L-peptide linking' y TYROSINE      ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE        ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1  LYS 1  1  ?  ?   ?   A . n 
A 1 2  CYS 2  2  2  CYS CYS A . n 
A 1 3  ASN 3  3  3  ASN ASN A . n 
A 1 4  THR 4  4  4  THR THR A . n 
A 1 5  ALA 5  5  5  ALA ALA A . n 
A 1 6  THR 6  6  6  THR THR A . n 
A 1 7  CYS 7  7  7  CYS CYS A . n 
A 1 8  ALA 8  8  8  ALA ALA A . n 
A 1 9  THR 9  9  9  THR THR A . n 
A 1 10 GLN 10 10 10 GLN GLN A . n 
A 1 11 ARG 11 11 11 ARG ARG A . n 
A 1 12 LEU 12 12 12 LEU LEU A . n 
A 1 13 ALA 13 13 13 ALA ALA A . n 
A 1 14 ASN 14 14 14 ASN ASN A . n 
A 1 15 PHE 15 15 15 PHE PHE A . n 
A 1 16 LEU 16 16 16 LEU LEU A . n 
A 1 17 VAL 17 17 17 VAL VAL A . n 
A 1 18 HIS 18 18 18 HIS HIS A . n 
A 1 19 SER 19 19 19 SER SER A . n 
A 1 20 SER 20 20 20 SER SER A . n 
A 1 21 ASN 21 21 21 ASN ASN A . n 
A 1 22 ASN 22 22 22 ASN ASN A . n 
A 1 23 PHE 23 23 23 PHE PHE A . n 
A 1 24 GLY 24 24 24 GLY GLY A . n 
A 1 25 ALA 25 25 25 ALA ALA A . n 
A 1 26 ILE 26 26 26 ILE ILE A . n 
A 1 27 LEU 27 27 27 LEU LEU A . n 
A 1 28 SER 28 28 28 SER SER A . n 
A 1 29 PRO 29 29 29 PRO PRO A . n 
A 1 30 THR 30 30 30 THR THR A . n 
A 1 31 ASN 31 31 31 ASN ASN A . n 
A 1 32 VAL 32 32 32 VAL VAL A . n 
A 1 33 GLY 33 33 33 GLY GLY A . n 
A 1 34 SER 34 34 34 SER SER A . n 
A 1 35 ASN 35 35 35 ASN ASN A . n 
A 1 36 THR 36 36 36 THR THR A . n 
A 1 37 TYR 37 37 37 TYR TYR A . n 
A 1 38 NH2 38 38 38 NH2 NH2 A . n 
B 1 1  LYS 1  1  ?  ?   ?   B . n 
B 1 2  CYS 2  2  ?  ?   ?   B . n 
B 1 3  ASN 3  3  ?  ?   ?   B . n 
B 1 4  THR 4  4  ?  ?   ?   B . n 
B 1 5  ALA 5  5  ?  ?   ?   B . n 
B 1 6  THR 6  6  ?  ?   ?   B . n 
B 1 7  CYS 7  7  ?  ?   ?   B . n 
B 1 8  ALA 8  8  ?  ?   ?   B . n 
B 1 9  THR 9  9  ?  ?   ?   B . n 
B 1 10 GLN 10 10 ?  ?   ?   B . n 
B 1 11 ARG 11 11 ?  ?   ?   B . n 
B 1 12 LEU 12 12 ?  ?   ?   B . n 
B 1 13 ALA 13 13 13 ALA ALA B . n 
B 1 14 ASN 14 14 14 ASN ASN B . n 
B 1 15 PHE 15 15 15 PHE PHE B . n 
B 1 16 LEU 16 16 16 LEU LEU B . n 
B 1 17 VAL 17 17 17 VAL VAL B . n 
B 1 18 HIS 18 18 18 HIS HIS B . n 
B 1 19 SER 19 19 19 SER SER B . n 
B 1 20 SER 20 20 20 SER SER B . n 
B 1 21 ASN 21 21 21 ASN ASN B . n 
B 1 22 ASN 22 22 22 ASN ASN B . n 
B 1 23 PHE 23 23 23 PHE PHE B . n 
B 1 24 GLY 24 24 24 GLY GLY B . n 
B 1 25 ALA 25 25 25 ALA ALA B . n 
B 1 26 ILE 26 26 26 ILE ILE B . n 
B 1 27 LEU 27 27 27 LEU LEU B . n 
B 1 28 SER 28 28 28 SER SER B . n 
B 1 29 PRO 29 29 29 PRO PRO B . n 
B 1 30 THR 30 30 30 THR THR B . n 
B 1 31 ASN 31 31 31 ASN ASN B . n 
B 1 32 VAL 32 32 32 VAL VAL B . n 
B 1 33 GLY 33 33 33 GLY GLY B . n 
B 1 34 SER 34 34 34 SER SER B . n 
B 1 35 ASN 35 35 35 ASN ASN B . n 
B 1 36 THR 36 36 36 THR THR B . n 
B 1 37 TYR 37 37 37 TYR TYR B . n 
B 1 38 NH2 38 38 38 NH2 NH2 B . n 
C 1 1  LYS 1  1  ?  ?   ?   C . n 
C 1 2  CYS 2  2  2  CYS CYS C . n 
C 1 3  ASN 3  3  3  ASN ASN C . n 
C 1 4  THR 4  4  4  THR THR C . n 
C 1 5  ALA 5  5  5  ALA ALA C . n 
C 1 6  THR 6  6  6  THR THR C . n 
C 1 7  CYS 7  7  7  CYS CYS C . n 
C 1 8  ALA 8  8  8  ALA ALA C . n 
C 1 9  THR 9  9  9  THR THR C . n 
C 1 10 GLN 10 10 10 GLN GLN C . n 
C 1 11 ARG 11 11 11 ARG ARG C . n 
C 1 12 LEU 12 12 12 LEU LEU C . n 
C 1 13 ALA 13 13 13 ALA ALA C . n 
C 1 14 ASN 14 14 14 ASN ASN C . n 
C 1 15 PHE 15 15 15 PHE PHE C . n 
C 1 16 LEU 16 16 16 LEU LEU C . n 
C 1 17 VAL 17 17 17 VAL VAL C . n 
C 1 18 HIS 18 18 18 HIS HIS C . n 
C 1 19 SER 19 19 19 SER SER C . n 
C 1 20 SER 20 20 20 SER SER C . n 
C 1 21 ASN 21 21 21 ASN ASN C . n 
C 1 22 ASN 22 22 22 ASN ASN C . n 
C 1 23 PHE 23 23 23 PHE PHE C . n 
C 1 24 GLY 24 24 24 GLY GLY C . n 
C 1 25 ALA 25 25 25 ALA ALA C . n 
C 1 26 ILE 26 26 26 ILE ILE C . n 
C 1 27 LEU 27 27 27 LEU LEU C . n 
C 1 28 SER 28 28 28 SER SER C . n 
C 1 29 PRO 29 29 29 PRO PRO C . n 
C 1 30 THR 30 30 30 THR THR C . n 
C 1 31 ASN 31 31 31 ASN ASN C . n 
C 1 32 VAL 32 32 32 VAL VAL C . n 
C 1 33 GLY 33 33 33 GLY GLY C . n 
C 1 34 SER 34 34 34 SER SER C . n 
C 1 35 ASN 35 35 35 ASN ASN C . n 
C 1 36 THR 36 36 36 THR THR C . n 
C 1 37 TYR 37 37 37 TYR TYR C . n 
C 1 38 NH2 38 38 38 NH2 NH2 C . n 
D 1 1  LYS 1  1  ?  ?   ?   D . n 
D 1 2  CYS 2  2  ?  ?   ?   D . n 
D 1 3  ASN 3  3  ?  ?   ?   D . n 
D 1 4  THR 4  4  ?  ?   ?   D . n 
D 1 5  ALA 5  5  ?  ?   ?   D . n 
D 1 6  THR 6  6  ?  ?   ?   D . n 
D 1 7  CYS 7  7  ?  ?   ?   D . n 
D 1 8  ALA 8  8  ?  ?   ?   D . n 
D 1 9  THR 9  9  ?  ?   ?   D . n 
D 1 10 GLN 10 10 ?  ?   ?   D . n 
D 1 11 ARG 11 11 ?  ?   ?   D . n 
D 1 12 LEU 12 12 ?  ?   ?   D . n 
D 1 13 ALA 13 13 13 ALA ALA D . n 
D 1 14 ASN 14 14 14 ASN ASN D . n 
D 1 15 PHE 15 15 15 PHE PHE D . n 
D 1 16 LEU 16 16 16 LEU LEU D . n 
D 1 17 VAL 17 17 17 VAL VAL D . n 
D 1 18 HIS 18 18 18 HIS HIS D . n 
D 1 19 SER 19 19 19 SER SER D . n 
D 1 20 SER 20 20 20 SER SER D . n 
D 1 21 ASN 21 21 21 ASN ASN D . n 
D 1 22 ASN 22 22 22 ASN ASN D . n 
D 1 23 PHE 23 23 23 PHE PHE D . n 
D 1 24 GLY 24 24 24 GLY GLY D . n 
D 1 25 ALA 25 25 25 ALA ALA D . n 
D 1 26 ILE 26 26 26 ILE ILE D . n 
D 1 27 LEU 27 27 27 LEU LEU D . n 
D 1 28 SER 28 28 28 SER SER D . n 
D 1 29 PRO 29 29 29 PRO PRO D . n 
D 1 30 THR 30 30 30 THR THR D . n 
D 1 31 ASN 31 31 31 ASN ASN D . n 
D 1 32 VAL 32 32 32 VAL VAL D . n 
D 1 33 GLY 33 33 33 GLY GLY D . n 
D 1 34 SER 34 34 34 SER SER D . n 
D 1 35 ASN 35 35 35 ASN ASN D . n 
D 1 36 THR 36 36 36 THR THR D . n 
D 1 37 TYR 37 37 37 TYR TYR D . n 
D 1 38 NH2 38 38 38 NH2 NH2 D . n 
E 1 1  LYS 1  1  ?  ?   ?   E . n 
E 1 2  CYS 2  2  2  CYS CYS E . n 
E 1 3  ASN 3  3  3  ASN ASN E . n 
E 1 4  THR 4  4  4  THR THR E . n 
E 1 5  ALA 5  5  5  ALA ALA E . n 
E 1 6  THR 6  6  6  THR THR E . n 
E 1 7  CYS 7  7  7  CYS CYS E . n 
E 1 8  ALA 8  8  8  ALA ALA E . n 
E 1 9  THR 9  9  9  THR THR E . n 
E 1 10 GLN 10 10 10 GLN GLN E . n 
E 1 11 ARG 11 11 11 ARG ARG E . n 
E 1 12 LEU 12 12 12 LEU LEU E . n 
E 1 13 ALA 13 13 13 ALA ALA E . n 
E 1 14 ASN 14 14 14 ASN ASN E . n 
E 1 15 PHE 15 15 15 PHE PHE E . n 
E 1 16 LEU 16 16 16 LEU LEU E . n 
E 1 17 VAL 17 17 17 VAL VAL E . n 
E 1 18 HIS 18 18 18 HIS HIS E . n 
E 1 19 SER 19 19 19 SER SER E . n 
E 1 20 SER 20 20 20 SER SER E . n 
E 1 21 ASN 21 21 21 ASN ASN E . n 
E 1 22 ASN 22 22 22 ASN ASN E . n 
E 1 23 PHE 23 23 23 PHE PHE E . n 
E 1 24 GLY 24 24 24 GLY GLY E . n 
E 1 25 ALA 25 25 25 ALA ALA E . n 
E 1 26 ILE 26 26 26 ILE ILE E . n 
E 1 27 LEU 27 27 27 LEU LEU E . n 
E 1 28 SER 28 28 28 SER SER E . n 
E 1 29 PRO 29 29 29 PRO PRO E . n 
E 1 30 THR 30 30 30 THR THR E . n 
E 1 31 ASN 31 31 31 ASN ASN E . n 
E 1 32 VAL 32 32 32 VAL VAL E . n 
E 1 33 GLY 33 33 33 GLY GLY E . n 
E 1 34 SER 34 34 34 SER SER E . n 
E 1 35 ASN 35 35 35 ASN ASN E . n 
E 1 36 THR 36 36 36 THR THR E . n 
E 1 37 TYR 37 37 37 TYR TYR E . n 
E 1 38 NH2 38 38 38 NH2 NH2 E . n 
F 1 1  LYS 1  1  ?  ?   ?   F . n 
F 1 2  CYS 2  2  ?  ?   ?   F . n 
F 1 3  ASN 3  3  ?  ?   ?   F . n 
F 1 4  THR 4  4  ?  ?   ?   F . n 
F 1 5  ALA 5  5  ?  ?   ?   F . n 
F 1 6  THR 6  6  ?  ?   ?   F . n 
F 1 7  CYS 7  7  ?  ?   ?   F . n 
F 1 8  ALA 8  8  ?  ?   ?   F . n 
F 1 9  THR 9  9  ?  ?   ?   F . n 
F 1 10 GLN 10 10 ?  ?   ?   F . n 
F 1 11 ARG 11 11 ?  ?   ?   F . n 
F 1 12 LEU 12 12 ?  ?   ?   F . n 
F 1 13 ALA 13 13 13 ALA ALA F . n 
F 1 14 ASN 14 14 14 ASN ASN F . n 
F 1 15 PHE 15 15 15 PHE PHE F . n 
F 1 16 LEU 16 16 16 LEU LEU F . n 
F 1 17 VAL 17 17 17 VAL VAL F . n 
F 1 18 HIS 18 18 18 HIS HIS F . n 
F 1 19 SER 19 19 19 SER SER F . n 
F 1 20 SER 20 20 20 SER SER F . n 
F 1 21 ASN 21 21 21 ASN ASN F . n 
F 1 22 ASN 22 22 22 ASN ASN F . n 
F 1 23 PHE 23 23 23 PHE PHE F . n 
F 1 24 GLY 24 24 24 GLY GLY F . n 
F 1 25 ALA 25 25 25 ALA ALA F . n 
F 1 26 ILE 26 26 26 ILE ILE F . n 
F 1 27 LEU 27 27 27 LEU LEU F . n 
F 1 28 SER 28 28 28 SER SER F . n 
F 1 29 PRO 29 29 29 PRO PRO F . n 
F 1 30 THR 30 30 30 THR THR F . n 
F 1 31 ASN 31 31 31 ASN ASN F . n 
F 1 32 VAL 32 32 32 VAL VAL F . n 
F 1 33 GLY 33 33 33 GLY GLY F . n 
F 1 34 SER 34 34 34 SER SER F . n 
F 1 35 ASN 35 35 35 ASN ASN F . n 
F 1 36 THR 36 36 36 THR THR F . n 
F 1 37 TYR 37 37 37 TYR TYR F . n 
F 1 38 NH2 38 38 38 NH2 NH2 F . n 
G 1 1  LYS 1  1  ?  ?   ?   G . n 
G 1 2  CYS 2  2  2  CYS CYS G . n 
G 1 3  ASN 3  3  3  ASN ASN G . n 
G 1 4  THR 4  4  4  THR THR G . n 
G 1 5  ALA 5  5  5  ALA ALA G . n 
G 1 6  THR 6  6  6  THR THR G . n 
G 1 7  CYS 7  7  7  CYS CYS G . n 
G 1 8  ALA 8  8  8  ALA ALA G . n 
G 1 9  THR 9  9  9  THR THR G . n 
G 1 10 GLN 10 10 10 GLN GLN G . n 
G 1 11 ARG 11 11 11 ARG ARG G . n 
G 1 12 LEU 12 12 12 LEU LEU G . n 
G 1 13 ALA 13 13 13 ALA ALA G . n 
G 1 14 ASN 14 14 14 ASN ASN G . n 
G 1 15 PHE 15 15 15 PHE PHE G . n 
G 1 16 LEU 16 16 16 LEU LEU G . n 
G 1 17 VAL 17 17 17 VAL VAL G . n 
G 1 18 HIS 18 18 18 HIS HIS G . n 
G 1 19 SER 19 19 19 SER SER G . n 
G 1 20 SER 20 20 20 SER SER G . n 
G 1 21 ASN 21 21 21 ASN ASN G . n 
G 1 22 ASN 22 22 22 ASN ASN G . n 
G 1 23 PHE 23 23 23 PHE PHE G . n 
G 1 24 GLY 24 24 24 GLY GLY G . n 
G 1 25 ALA 25 25 25 ALA ALA G . n 
G 1 26 ILE 26 26 26 ILE ILE G . n 
G 1 27 LEU 27 27 27 LEU LEU G . n 
G 1 28 SER 28 28 28 SER SER G . n 
G 1 29 PRO 29 29 29 PRO PRO G . n 
G 1 30 THR 30 30 30 THR THR G . n 
G 1 31 ASN 31 31 31 ASN ASN G . n 
G 1 32 VAL 32 32 32 VAL VAL G . n 
G 1 33 GLY 33 33 33 GLY GLY G . n 
G 1 34 SER 34 34 34 SER SER G . n 
G 1 35 ASN 35 35 35 ASN ASN G . n 
G 1 36 THR 36 36 36 THR THR G . n 
G 1 37 TYR 37 37 37 TYR TYR G . n 
G 1 38 NH2 38 38 38 NH2 NH2 G . n 
H 1 1  LYS 1  1  ?  ?   ?   H . n 
H 1 2  CYS 2  2  ?  ?   ?   H . n 
H 1 3  ASN 3  3  ?  ?   ?   H . n 
H 1 4  THR 4  4  ?  ?   ?   H . n 
H 1 5  ALA 5  5  ?  ?   ?   H . n 
H 1 6  THR 6  6  ?  ?   ?   H . n 
H 1 7  CYS 7  7  ?  ?   ?   H . n 
H 1 8  ALA 8  8  ?  ?   ?   H . n 
H 1 9  THR 9  9  ?  ?   ?   H . n 
H 1 10 GLN 10 10 ?  ?   ?   H . n 
H 1 11 ARG 11 11 ?  ?   ?   H . n 
H 1 12 LEU 12 12 ?  ?   ?   H . n 
H 1 13 ALA 13 13 13 ALA ALA H . n 
H 1 14 ASN 14 14 14 ASN ASN H . n 
H 1 15 PHE 15 15 15 PHE PHE H . n 
H 1 16 LEU 16 16 16 LEU LEU H . n 
H 1 17 VAL 17 17 17 VAL VAL H . n 
H 1 18 HIS 18 18 18 HIS HIS H . n 
H 1 19 SER 19 19 19 SER SER H . n 
H 1 20 SER 20 20 20 SER SER H . n 
H 1 21 ASN 21 21 21 ASN ASN H . n 
H 1 22 ASN 22 22 22 ASN ASN H . n 
H 1 23 PHE 23 23 23 PHE PHE H . n 
H 1 24 GLY 24 24 24 GLY GLY H . n 
H 1 25 ALA 25 25 25 ALA ALA H . n 
H 1 26 ILE 26 26 26 ILE ILE H . n 
H 1 27 LEU 27 27 27 LEU LEU H . n 
H 1 28 SER 28 28 28 SER SER H . n 
H 1 29 PRO 29 29 29 PRO PRO H . n 
H 1 30 THR 30 30 30 THR THR H . n 
H 1 31 ASN 31 31 31 ASN ASN H . n 
H 1 32 VAL 32 32 32 VAL VAL H . n 
H 1 33 GLY 33 33 33 GLY GLY H . n 
H 1 34 SER 34 34 34 SER SER H . n 
H 1 35 ASN 35 35 35 ASN ASN H . n 
H 1 36 THR 36 36 36 THR THR H . n 
H 1 37 TYR 37 37 37 TYR TYR H . n 
H 1 38 NH2 38 38 38 NH2 NH2 H . n 
I 1 1  LYS 1  1  ?  ?   ?   I . n 
I 1 2  CYS 2  2  2  CYS CYS I . n 
I 1 3  ASN 3  3  3  ASN ASN I . n 
I 1 4  THR 4  4  4  THR THR I . n 
I 1 5  ALA 5  5  5  ALA ALA I . n 
I 1 6  THR 6  6  6  THR THR I . n 
I 1 7  CYS 7  7  7  CYS CYS I . n 
I 1 8  ALA 8  8  8  ALA ALA I . n 
I 1 9  THR 9  9  9  THR THR I . n 
I 1 10 GLN 10 10 10 GLN GLN I . n 
I 1 11 ARG 11 11 11 ARG ARG I . n 
I 1 12 LEU 12 12 12 LEU LEU I . n 
I 1 13 ALA 13 13 13 ALA ALA I . n 
I 1 14 ASN 14 14 14 ASN ASN I . n 
I 1 15 PHE 15 15 15 PHE PHE I . n 
I 1 16 LEU 16 16 16 LEU LEU I . n 
I 1 17 VAL 17 17 17 VAL VAL I . n 
I 1 18 HIS 18 18 18 HIS HIS I . n 
I 1 19 SER 19 19 19 SER SER I . n 
I 1 20 SER 20 20 20 SER SER I . n 
I 1 21 ASN 21 21 21 ASN ASN I . n 
I 1 22 ASN 22 22 22 ASN ASN I . n 
I 1 23 PHE 23 23 23 PHE PHE I . n 
I 1 24 GLY 24 24 24 GLY GLY I . n 
I 1 25 ALA 25 25 25 ALA ALA I . n 
I 1 26 ILE 26 26 26 ILE ILE I . n 
I 1 27 LEU 27 27 27 LEU LEU I . n 
I 1 28 SER 28 28 28 SER SER I . n 
I 1 29 PRO 29 29 29 PRO PRO I . n 
I 1 30 THR 30 30 30 THR THR I . n 
I 1 31 ASN 31 31 31 ASN ASN I . n 
I 1 32 VAL 32 32 32 VAL VAL I . n 
I 1 33 GLY 33 33 33 GLY GLY I . n 
I 1 34 SER 34 34 34 SER SER I . n 
I 1 35 ASN 35 35 35 ASN ASN I . n 
I 1 36 THR 36 36 36 THR THR I . n 
I 1 37 TYR 37 37 37 TYR TYR I . n 
I 1 38 NH2 38 38 38 NH2 NH2 I . n 
J 1 1  LYS 1  1  ?  ?   ?   J . n 
J 1 2  CYS 2  2  ?  ?   ?   J . n 
J 1 3  ASN 3  3  ?  ?   ?   J . n 
J 1 4  THR 4  4  ?  ?   ?   J . n 
J 1 5  ALA 5  5  ?  ?   ?   J . n 
J 1 6  THR 6  6  ?  ?   ?   J . n 
J 1 7  CYS 7  7  ?  ?   ?   J . n 
J 1 8  ALA 8  8  ?  ?   ?   J . n 
J 1 9  THR 9  9  ?  ?   ?   J . n 
J 1 10 GLN 10 10 ?  ?   ?   J . n 
J 1 11 ARG 11 11 ?  ?   ?   J . n 
J 1 12 LEU 12 12 ?  ?   ?   J . n 
J 1 13 ALA 13 13 13 ALA ALA J . n 
J 1 14 ASN 14 14 14 ASN ASN J . n 
J 1 15 PHE 15 15 15 PHE PHE J . n 
J 1 16 LEU 16 16 16 LEU LEU J . n 
J 1 17 VAL 17 17 17 VAL VAL J . n 
J 1 18 HIS 18 18 18 HIS HIS J . n 
J 1 19 SER 19 19 19 SER SER J . n 
J 1 20 SER 20 20 20 SER SER J . n 
J 1 21 ASN 21 21 21 ASN ASN J . n 
J 1 22 ASN 22 22 22 ASN ASN J . n 
J 1 23 PHE 23 23 23 PHE PHE J . n 
J 1 24 GLY 24 24 24 GLY GLY J . n 
J 1 25 ALA 25 25 25 ALA ALA J . n 
J 1 26 ILE 26 26 26 ILE ILE J . n 
J 1 27 LEU 27 27 27 LEU LEU J . n 
J 1 28 SER 28 28 28 SER SER J . n 
J 1 29 PRO 29 29 29 PRO PRO J . n 
J 1 30 THR 30 30 30 THR THR J . n 
J 1 31 ASN 31 31 31 ASN ASN J . n 
J 1 32 VAL 32 32 32 VAL VAL J . n 
J 1 33 GLY 33 33 33 GLY GLY J . n 
J 1 34 SER 34 34 34 SER SER J . n 
J 1 35 ASN 35 35 35 ASN ASN J . n 
J 1 36 THR 36 36 36 THR THR J . n 
J 1 37 TYR 37 37 37 TYR TYR J . n 
J 1 38 NH2 38 38 38 NH2 NH2 J . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        NH2 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   NH2 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8QVR 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_struct.entry_id                     8QVR 
_struct.title                        'Cryo-EM structure of human islet amyloid polypeptide (hIAPP) mutant S29P, polymorph 3' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8QVR 
_struct_keywords.text            'amyloid, PROTEIN FIBRIL' 
_struct_keywords.pdbx_keywords   'PROTEIN FIBRIL' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 1 ? 
D N N 1 ? 
E N N 1 ? 
F N N 1 ? 
G N N 1 ? 
H N N 1 ? 
I N N 1 ? 
J N N 1 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    IAPP_HUMAN 
_struct_ref.pdbx_db_accession          P10997 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY 
_struct_ref.pdbx_align_begin           34 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1  1 8QVR A 1 ? 37 ? P10997 34 ? 70 ? 1 37 
2  1 8QVR B 1 ? 37 ? P10997 34 ? 70 ? 1 37 
3  1 8QVR C 1 ? 37 ? P10997 34 ? 70 ? 1 37 
4  1 8QVR D 1 ? 37 ? P10997 34 ? 70 ? 1 37 
5  1 8QVR E 1 ? 37 ? P10997 34 ? 70 ? 1 37 
6  1 8QVR F 1 ? 37 ? P10997 34 ? 70 ? 1 37 
7  1 8QVR G 1 ? 37 ? P10997 34 ? 70 ? 1 37 
8  1 8QVR H 1 ? 37 ? P10997 34 ? 70 ? 1 37 
9  1 8QVR I 1 ? 37 ? P10997 34 ? 70 ? 1 37 
10 1 8QVR J 1 ? 37 ? P10997 34 ? 70 ? 1 37 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1  8QVR PRO A 29 ? UNP P10997 SER 62 'engineered mutation' 29 1  
1  8QVR NH2 A 38 ? UNP P10997 ?   ?  amidation             38 2  
2  8QVR PRO B 29 ? UNP P10997 SER 62 'engineered mutation' 29 3  
2  8QVR NH2 B 38 ? UNP P10997 ?   ?  amidation             38 4  
3  8QVR PRO C 29 ? UNP P10997 SER 62 'engineered mutation' 29 5  
3  8QVR NH2 C 38 ? UNP P10997 ?   ?  amidation             38 6  
4  8QVR PRO D 29 ? UNP P10997 SER 62 'engineered mutation' 29 7  
4  8QVR NH2 D 38 ? UNP P10997 ?   ?  amidation             38 8  
5  8QVR PRO E 29 ? UNP P10997 SER 62 'engineered mutation' 29 9  
5  8QVR NH2 E 38 ? UNP P10997 ?   ?  amidation             38 10 
6  8QVR PRO F 29 ? UNP P10997 SER 62 'engineered mutation' 29 11 
6  8QVR NH2 F 38 ? UNP P10997 ?   ?  amidation             38 12 
7  8QVR PRO G 29 ? UNP P10997 SER 62 'engineered mutation' 29 13 
7  8QVR NH2 G 38 ? UNP P10997 ?   ?  amidation             38 14 
8  8QVR PRO H 29 ? UNP P10997 SER 62 'engineered mutation' 29 15 
8  8QVR NH2 H 38 ? UNP P10997 ?   ?  amidation             38 16 
9  8QVR PRO I 29 ? UNP P10997 SER 62 'engineered mutation' 29 17 
9  8QVR NH2 I 38 ? UNP P10997 ?   ?  amidation             38 18 
10 8QVR PRO J 29 ? UNP P10997 SER 62 'engineered mutation' 29 19 
10 8QVR NH2 J 38 ? UNP P10997 ?   ?  amidation             38 20 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   decameric 
_pdbx_struct_assembly.oligomeric_count     10 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1  disulf ?    ? A CYS 2  SG ? ? ? 1_555 A CYS 7  SG ? ? A CYS 2  A CYS 7  1_555 ? ? ? ? ? ? ? 2.030 ? ? 
disulf2  disulf ?    ? C CYS 2  SG ? ? ? 1_555 C CYS 7  SG ? ? C CYS 2  C CYS 7  1_555 ? ? ? ? ? ? ? 2.031 ? ? 
disulf3  disulf ?    ? E CYS 2  SG ? ? ? 1_555 E CYS 7  SG ? ? E CYS 2  E CYS 7  1_555 ? ? ? ? ? ? ? 2.032 ? ? 
disulf4  disulf ?    ? G CYS 2  SG ? ? ? 1_555 G CYS 7  SG ? ? G CYS 2  G CYS 7  1_555 ? ? ? ? ? ? ? 2.031 ? ? 
disulf5  disulf ?    ? I CYS 2  SG ? ? ? 1_555 I CYS 7  SG ? ? I CYS 2  I CYS 7  1_555 ? ? ? ? ? ? ? 2.031 ? ? 
covale1  covale both ? A TYR 37 C  ? ? ? 1_555 A NH2 38 N  ? ? A TYR 37 A NH2 38 1_555 ? ? ? ? ? ? ? 1.330 ? ? 
covale2  covale both ? B TYR 37 C  ? ? ? 1_555 B NH2 38 N  ? ? B TYR 37 B NH2 38 1_555 ? ? ? ? ? ? ? 1.329 ? ? 
covale3  covale both ? C TYR 37 C  ? ? ? 1_555 C NH2 38 N  ? ? C TYR 37 C NH2 38 1_555 ? ? ? ? ? ? ? 1.329 ? ? 
covale4  covale both ? D TYR 37 C  ? ? ? 1_555 D NH2 38 N  ? ? D TYR 37 D NH2 38 1_555 ? ? ? ? ? ? ? 1.329 ? ? 
covale5  covale both ? E TYR 37 C  ? ? ? 1_555 E NH2 38 N  ? ? E TYR 37 E NH2 38 1_555 ? ? ? ? ? ? ? 1.330 ? ? 
covale6  covale both ? F TYR 37 C  ? ? ? 1_555 F NH2 38 N  ? ? F TYR 37 F NH2 38 1_555 ? ? ? ? ? ? ? 1.328 ? ? 
covale7  covale both ? G TYR 37 C  ? ? ? 1_555 G NH2 38 N  ? ? G TYR 37 G NH2 38 1_555 ? ? ? ? ? ? ? 1.329 ? ? 
covale8  covale both ? H TYR 37 C  ? ? ? 1_555 H NH2 38 N  ? ? H TYR 37 H NH2 38 1_555 ? ? ? ? ? ? ? 1.329 ? ? 
covale9  covale both ? I TYR 37 C  ? ? ? 1_555 I NH2 38 N  ? ? I TYR 37 I NH2 38 1_555 ? ? ? ? ? ? ? 1.328 ? ? 
covale10 covale both ? J TYR 37 C  ? ? ? 1_555 J NH2 38 N  ? ? J TYR 37 J NH2 38 1_555 ? ? ? ? ? ? ? 1.329 ? ? 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
covale ? ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1  NH2 A 38 ? TYR A 37 ? NH2 A 38 ? 1_555 TYR A 37 ? 1_555 .  .  TYR 5 NH2 None 'Terminal amidation' 
2  NH2 B 38 ? TYR B 37 ? NH2 B 38 ? 1_555 TYR B 37 ? 1_555 .  .  TYR 5 NH2 None 'Terminal amidation' 
3  NH2 C 38 ? TYR C 37 ? NH2 C 38 ? 1_555 TYR C 37 ? 1_555 .  .  TYR 5 NH2 None 'Terminal amidation' 
4  NH2 D 38 ? TYR D 37 ? NH2 D 38 ? 1_555 TYR D 37 ? 1_555 .  .  TYR 5 NH2 None 'Terminal amidation' 
5  NH2 E 38 ? TYR E 37 ? NH2 E 38 ? 1_555 TYR E 37 ? 1_555 .  .  TYR 5 NH2 None 'Terminal amidation' 
6  NH2 F 38 ? TYR F 37 ? NH2 F 38 ? 1_555 TYR F 37 ? 1_555 .  .  TYR 5 NH2 None 'Terminal amidation' 
7  NH2 G 38 ? TYR G 37 ? NH2 G 38 ? 1_555 TYR G 37 ? 1_555 .  .  TYR 5 NH2 None 'Terminal amidation' 
8  NH2 H 38 ? TYR H 37 ? NH2 H 38 ? 1_555 TYR H 37 ? 1_555 .  .  TYR 5 NH2 None 'Terminal amidation' 
9  NH2 I 38 ? TYR I 37 ? NH2 I 38 ? 1_555 TYR I 37 ? 1_555 .  .  TYR 5 NH2 None 'Terminal amidation' 
10 NH2 J 38 ? TYR J 37 ? NH2 J 38 ? 1_555 TYR J 37 ? 1_555 .  .  TYR 5 NH2 None 'Terminal amidation' 
11 CYS A 2  ? CYS A 7  ? CYS A 2  ? 1_555 CYS A 7  ? 1_555 SG SG .   . .   None 'Disulfide bridge'   
12 CYS C 2  ? CYS C 7  ? CYS C 2  ? 1_555 CYS C 7  ? 1_555 SG SG .   . .   None 'Disulfide bridge'   
13 CYS E 2  ? CYS E 7  ? CYS E 2  ? 1_555 CYS E 7  ? 1_555 SG SG .   . .   None 'Disulfide bridge'   
14 CYS G 2  ? CYS G 7  ? CYS G 2  ? 1_555 CYS G 7  ? 1_555 SG SG .   . .   None 'Disulfide bridge'   
15 CYS I 2  ? CYS I 7  ? CYS I 2  ? 1_555 CYS I 7  ? 1_555 SG SG .   . .   None 'Disulfide bridge'   
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 5 ? 
AA3 ? 2 ? 
AA4 ? 5 ? 
AA5 ? 5 ? 
AA6 ? 5 ? 
AA7 ? 5 ? 
AA8 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel 
AA1 2 3 ? parallel 
AA1 3 4 ? parallel 
AA1 4 5 ? parallel 
AA2 1 2 ? parallel 
AA2 2 3 ? parallel 
AA2 3 4 ? parallel 
AA2 4 5 ? parallel 
AA3 1 2 ? parallel 
AA4 1 2 ? parallel 
AA4 2 3 ? parallel 
AA4 3 4 ? parallel 
AA4 4 5 ? parallel 
AA5 1 2 ? parallel 
AA5 2 3 ? parallel 
AA5 3 4 ? parallel 
AA5 4 5 ? parallel 
AA6 1 2 ? parallel 
AA6 2 3 ? parallel 
AA6 3 4 ? parallel 
AA6 4 5 ? parallel 
AA7 1 2 ? parallel 
AA7 2 3 ? parallel 
AA7 3 4 ? parallel 
AA7 4 5 ? parallel 
AA8 1 2 ? parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 THR A 9  ? ALA A 13 ? THR A 9  ALA A 13 
AA1 2 THR C 9  ? ALA C 13 ? THR C 9  ALA C 13 
AA1 3 THR E 9  ? ALA E 13 ? THR E 9  ALA E 13 
AA1 4 THR G 9  ? ALA G 13 ? THR G 9  ALA G 13 
AA1 5 THR I 9  ? ALA I 13 ? THR I 9  ALA I 13 
AA2 1 LEU A 16 ? HIS A 18 ? LEU A 16 HIS A 18 
AA2 2 LEU C 16 ? HIS C 18 ? LEU C 16 HIS C 18 
AA2 3 LEU E 16 ? HIS E 18 ? LEU E 16 HIS E 18 
AA2 4 LEU G 16 ? HIS G 18 ? LEU G 16 HIS G 18 
AA2 5 LEU I 16 ? HIS I 18 ? LEU I 16 HIS I 18 
AA3 1 ASN A 21 ? ASN A 22 ? ASN A 21 ASN A 22 
AA3 2 ASN C 21 ? ASN C 22 ? ASN C 21 ASN C 22 
AA4 1 THR A 30 ? VAL A 32 ? THR A 30 VAL A 32 
AA4 2 THR C 30 ? VAL C 32 ? THR C 30 VAL C 32 
AA4 3 THR E 30 ? VAL E 32 ? THR E 30 VAL E 32 
AA4 4 THR G 30 ? VAL G 32 ? THR G 30 VAL G 32 
AA4 5 THR I 30 ? VAL I 32 ? THR I 30 VAL I 32 
AA5 1 ASN A 35 ? THR A 36 ? ASN A 35 THR A 36 
AA5 2 ASN C 35 ? THR C 36 ? ASN C 35 THR C 36 
AA5 3 ASN E 35 ? THR E 36 ? ASN E 35 THR E 36 
AA5 4 ASN G 35 ? THR G 36 ? ASN G 35 THR G 36 
AA5 5 ASN I 35 ? THR I 36 ? ASN I 35 THR I 36 
AA6 1 PHE B 15 ? ASN B 22 ? PHE B 15 ASN B 22 
AA6 2 PHE D 15 ? ASN D 22 ? PHE D 15 ASN D 22 
AA6 3 PHE F 15 ? ASN F 22 ? PHE F 15 ASN F 22 
AA6 4 PHE H 15 ? ASN H 22 ? PHE H 15 ASN H 22 
AA6 5 PHE J 15 ? ASN J 22 ? PHE J 15 ASN J 22 
AA7 1 ASN B 35 ? THR B 36 ? ASN B 35 THR B 36 
AA7 2 ASN D 35 ? THR D 36 ? ASN D 35 THR D 36 
AA7 3 ASN F 35 ? THR F 36 ? ASN F 35 THR F 36 
AA7 4 ASN H 35 ? THR H 36 ? ASN H 35 THR H 36 
AA7 5 ASN J 35 ? THR J 36 ? ASN J 35 THR J 36 
AA8 1 ASN E 21 ? ASN E 22 ? ASN E 21 ASN E 22 
AA8 2 ASN G 21 ? ASN G 22 ? ASN G 21 ASN G 22 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N LEU A 12 ? N LEU A 12 O ARG C 11 ? O ARG C 11 
AA1 2 3 N LEU C 12 ? N LEU C 12 O ARG E 11 ? O ARG E 11 
AA1 3 4 N LEU E 12 ? N LEU E 12 O ARG G 11 ? O ARG G 11 
AA1 4 5 N LEU G 12 ? N LEU G 12 O ARG I 11 ? O ARG I 11 
AA2 1 2 N VAL A 17 ? N VAL A 17 O LEU C 16 ? O LEU C 16 
AA2 2 3 N VAL C 17 ? N VAL C 17 O HIS E 18 ? O HIS E 18 
AA2 3 4 N VAL E 17 ? N VAL E 17 O LEU G 16 ? O LEU G 16 
AA2 4 5 N VAL G 17 ? N VAL G 17 O LEU I 16 ? O LEU I 16 
AA3 1 2 N ASN A 22 ? N ASN A 22 O ASN C 21 ? O ASN C 21 
AA4 1 2 N ASN A 31 ? N ASN A 31 O THR C 30 ? O THR C 30 
AA4 2 3 N ASN C 31 ? N ASN C 31 O THR E 30 ? O THR E 30 
AA4 3 4 N ASN E 31 ? N ASN E 31 O THR G 30 ? O THR G 30 
AA4 4 5 N ASN G 31 ? N ASN G 31 O THR I 30 ? O THR I 30 
AA5 1 2 N THR A 36 ? N THR A 36 O ASN C 35 ? O ASN C 35 
AA5 2 3 N THR C 36 ? N THR C 36 O ASN E 35 ? O ASN E 35 
AA5 3 4 N THR E 36 ? N THR E 36 O ASN G 35 ? O ASN G 35 
AA5 4 5 N THR G 36 ? N THR G 36 O ASN I 35 ? O ASN I 35 
AA6 1 2 N SER B 20 ? N SER B 20 O SER D 19 ? O SER D 19 
AA6 2 3 N SER D 20 ? N SER D 20 O SER F 19 ? O SER F 19 
AA6 3 4 N SER F 20 ? N SER F 20 O SER H 19 ? O SER H 19 
AA6 4 5 N SER H 20 ? N SER H 20 O SER J 19 ? O SER J 19 
AA7 1 2 N THR B 36 ? N THR B 36 O ASN D 35 ? O ASN D 35 
AA7 2 3 N THR D 36 ? N THR D 36 O ASN F 35 ? O ASN F 35 
AA7 3 4 N THR F 36 ? N THR F 36 O ASN H 35 ? O ASN H 35 
AA7 4 5 N THR H 36 ? N THR H 36 O ASN J 35 ? O ASN J 35 
AA8 1 2 N ASN E 22 ? N ASN E 22 O ASN G 21 ? O ASN G 21 
# 
_pdbx_entry_details.entry_id                   8QVR 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ILE B 26 ? ? -122.22 -62.46 
2 1 ILE D 26 ? ? -122.31 -62.54 
3 1 ILE F 26 ? ? -122.23 -62.41 
4 1 ILE H 26 ? ? -122.14 -62.35 
5 1 ILE J 26 ? ? -122.19 -62.55 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          8QVR 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    8QVR 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.80 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               6374 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               HELICAL 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.4 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               'MULTIPLE SOURCES' 
_em_entity_assembly.type                 CELL 
_em_entity_assembly.name                 'Human islet amyloid polypeptide (hIAPP)' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        8QVR 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'TFS KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             600 
_em_imaging.nominal_defocus_max             2400 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           165000 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
_em_imaging.objective_aperture              ? 
_em_imaging.microscope_serial_number        ? 
_em_imaging.microscope_version              ? 
# 
_em_vitrification.entry_id              8QVR 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE-PROPANE 
_em_vitrification.humidity              100 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   277.15 
_em_vitrification.instrument            'FEI VITROBOT MARK IV' 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                8QVR 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   HELICAL 
_em_experiment.aggregation_state       FILAMENT 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A LYS 1  ? A LYS 1  
2  1 Y 1 B LYS 1  ? B LYS 1  
3  1 Y 1 B CYS 2  ? B CYS 2  
4  1 Y 1 B ASN 3  ? B ASN 3  
5  1 Y 1 B THR 4  ? B THR 4  
6  1 Y 1 B ALA 5  ? B ALA 5  
7  1 Y 1 B THR 6  ? B THR 6  
8  1 Y 1 B CYS 7  ? B CYS 7  
9  1 Y 1 B ALA 8  ? B ALA 8  
10 1 Y 1 B THR 9  ? B THR 9  
11 1 Y 1 B GLN 10 ? B GLN 10 
12 1 Y 1 B ARG 11 ? B ARG 11 
13 1 Y 1 B LEU 12 ? B LEU 12 
14 1 Y 1 C LYS 1  ? C LYS 1  
15 1 Y 1 D LYS 1  ? D LYS 1  
16 1 Y 1 D CYS 2  ? D CYS 2  
17 1 Y 1 D ASN 3  ? D ASN 3  
18 1 Y 1 D THR 4  ? D THR 4  
19 1 Y 1 D ALA 5  ? D ALA 5  
20 1 Y 1 D THR 6  ? D THR 6  
21 1 Y 1 D CYS 7  ? D CYS 7  
22 1 Y 1 D ALA 8  ? D ALA 8  
23 1 Y 1 D THR 9  ? D THR 9  
24 1 Y 1 D GLN 10 ? D GLN 10 
25 1 Y 1 D ARG 11 ? D ARG 11 
26 1 Y 1 D LEU 12 ? D LEU 12 
27 1 Y 1 E LYS 1  ? E LYS 1  
28 1 Y 1 F LYS 1  ? F LYS 1  
29 1 Y 1 F CYS 2  ? F CYS 2  
30 1 Y 1 F ASN 3  ? F ASN 3  
31 1 Y 1 F THR 4  ? F THR 4  
32 1 Y 1 F ALA 5  ? F ALA 5  
33 1 Y 1 F THR 6  ? F THR 6  
34 1 Y 1 F CYS 7  ? F CYS 7  
35 1 Y 1 F ALA 8  ? F ALA 8  
36 1 Y 1 F THR 9  ? F THR 9  
37 1 Y 1 F GLN 10 ? F GLN 10 
38 1 Y 1 F ARG 11 ? F ARG 11 
39 1 Y 1 F LEU 12 ? F LEU 12 
40 1 Y 1 G LYS 1  ? G LYS 1  
41 1 Y 1 H LYS 1  ? H LYS 1  
42 1 Y 1 H CYS 2  ? H CYS 2  
43 1 Y 1 H ASN 3  ? H ASN 3  
44 1 Y 1 H THR 4  ? H THR 4  
45 1 Y 1 H ALA 5  ? H ALA 5  
46 1 Y 1 H THR 6  ? H THR 6  
47 1 Y 1 H CYS 7  ? H CYS 7  
48 1 Y 1 H ALA 8  ? H ALA 8  
49 1 Y 1 H THR 9  ? H THR 9  
50 1 Y 1 H GLN 10 ? H GLN 10 
51 1 Y 1 H ARG 11 ? H ARG 11 
52 1 Y 1 H LEU 12 ? H LEU 12 
53 1 Y 1 I LYS 1  ? I LYS 1  
54 1 Y 1 J LYS 1  ? J LYS 1  
55 1 Y 1 J CYS 2  ? J CYS 2  
56 1 Y 1 J ASN 3  ? J ASN 3  
57 1 Y 1 J THR 4  ? J THR 4  
58 1 Y 1 J ALA 5  ? J ALA 5  
59 1 Y 1 J THR 6  ? J THR 6  
60 1 Y 1 J CYS 7  ? J CYS 7  
61 1 Y 1 J ALA 8  ? J ALA 8  
62 1 Y 1 J THR 9  ? J THR 9  
63 1 Y 1 J GLN 10 ? J GLN 10 
64 1 Y 1 J ARG 11 ? J ARG 11 
65 1 Y 1 J LEU 12 ? J LEU 12 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
CYS N    N N N 58  
CYS CA   C N R 59  
CYS C    C N N 60  
CYS O    O N N 61  
CYS CB   C N N 62  
CYS SG   S N N 63  
CYS OXT  O N N 64  
CYS H    H N N 65  
CYS H2   H N N 66  
CYS HA   H N N 67  
CYS HB2  H N N 68  
CYS HB3  H N N 69  
CYS HG   H N N 70  
CYS HXT  H N N 71  
GLN N    N N N 72  
GLN CA   C N S 73  
GLN C    C N N 74  
GLN O    O N N 75  
GLN CB   C N N 76  
GLN CG   C N N 77  
GLN CD   C N N 78  
GLN OE1  O N N 79  
GLN NE2  N N N 80  
GLN OXT  O N N 81  
GLN H    H N N 82  
GLN H2   H N N 83  
GLN HA   H N N 84  
GLN HB2  H N N 85  
GLN HB3  H N N 86  
GLN HG2  H N N 87  
GLN HG3  H N N 88  
GLN HE21 H N N 89  
GLN HE22 H N N 90  
GLN HXT  H N N 91  
GLY N    N N N 92  
GLY CA   C N N 93  
GLY C    C N N 94  
GLY O    O N N 95  
GLY OXT  O N N 96  
GLY H    H N N 97  
GLY H2   H N N 98  
GLY HA2  H N N 99  
GLY HA3  H N N 100 
GLY HXT  H N N 101 
HIS N    N N N 102 
HIS CA   C N S 103 
HIS C    C N N 104 
HIS O    O N N 105 
HIS CB   C N N 106 
HIS CG   C Y N 107 
HIS ND1  N Y N 108 
HIS CD2  C Y N 109 
HIS CE1  C Y N 110 
HIS NE2  N Y N 111 
HIS OXT  O N N 112 
HIS H    H N N 113 
HIS H2   H N N 114 
HIS HA   H N N 115 
HIS HB2  H N N 116 
HIS HB3  H N N 117 
HIS HD1  H N N 118 
HIS HD2  H N N 119 
HIS HE1  H N N 120 
HIS HE2  H N N 121 
HIS HXT  H N N 122 
ILE N    N N N 123 
ILE CA   C N S 124 
ILE C    C N N 125 
ILE O    O N N 126 
ILE CB   C N S 127 
ILE CG1  C N N 128 
ILE CG2  C N N 129 
ILE CD1  C N N 130 
ILE OXT  O N N 131 
ILE H    H N N 132 
ILE H2   H N N 133 
ILE HA   H N N 134 
ILE HB   H N N 135 
ILE HG12 H N N 136 
ILE HG13 H N N 137 
ILE HG21 H N N 138 
ILE HG22 H N N 139 
ILE HG23 H N N 140 
ILE HD11 H N N 141 
ILE HD12 H N N 142 
ILE HD13 H N N 143 
ILE HXT  H N N 144 
LEU N    N N N 145 
LEU CA   C N S 146 
LEU C    C N N 147 
LEU O    O N N 148 
LEU CB   C N N 149 
LEU CG   C N N 150 
LEU CD1  C N N 151 
LEU CD2  C N N 152 
LEU OXT  O N N 153 
LEU H    H N N 154 
LEU H2   H N N 155 
LEU HA   H N N 156 
LEU HB2  H N N 157 
LEU HB3  H N N 158 
LEU HG   H N N 159 
LEU HD11 H N N 160 
LEU HD12 H N N 161 
LEU HD13 H N N 162 
LEU HD21 H N N 163 
LEU HD22 H N N 164 
LEU HD23 H N N 165 
LEU HXT  H N N 166 
LYS N    N N N 167 
LYS CA   C N S 168 
LYS C    C N N 169 
LYS O    O N N 170 
LYS CB   C N N 171 
LYS CG   C N N 172 
LYS CD   C N N 173 
LYS CE   C N N 174 
LYS NZ   N N N 175 
LYS OXT  O N N 176 
LYS H    H N N 177 
LYS H2   H N N 178 
LYS HA   H N N 179 
LYS HB2  H N N 180 
LYS HB3  H N N 181 
LYS HG2  H N N 182 
LYS HG3  H N N 183 
LYS HD2  H N N 184 
LYS HD3  H N N 185 
LYS HE2  H N N 186 
LYS HE3  H N N 187 
LYS HZ1  H N N 188 
LYS HZ2  H N N 189 
LYS HZ3  H N N 190 
LYS HXT  H N N 191 
NH2 N    N N N 192 
NH2 HN1  H N N 193 
NH2 HN2  H N N 194 
PHE N    N N N 195 
PHE CA   C N S 196 
PHE C    C N N 197 
PHE O    O N N 198 
PHE CB   C N N 199 
PHE CG   C Y N 200 
PHE CD1  C Y N 201 
PHE CD2  C Y N 202 
PHE CE1  C Y N 203 
PHE CE2  C Y N 204 
PHE CZ   C Y N 205 
PHE OXT  O N N 206 
PHE H    H N N 207 
PHE H2   H N N 208 
PHE HA   H N N 209 
PHE HB2  H N N 210 
PHE HB3  H N N 211 
PHE HD1  H N N 212 
PHE HD2  H N N 213 
PHE HE1  H N N 214 
PHE HE2  H N N 215 
PHE HZ   H N N 216 
PHE HXT  H N N 217 
PRO N    N N N 218 
PRO CA   C N S 219 
PRO C    C N N 220 
PRO O    O N N 221 
PRO CB   C N N 222 
PRO CG   C N N 223 
PRO CD   C N N 224 
PRO OXT  O N N 225 
PRO H    H N N 226 
PRO HA   H N N 227 
PRO HB2  H N N 228 
PRO HB3  H N N 229 
PRO HG2  H N N 230 
PRO HG3  H N N 231 
PRO HD2  H N N 232 
PRO HD3  H N N 233 
PRO HXT  H N N 234 
SER N    N N N 235 
SER CA   C N S 236 
SER C    C N N 237 
SER O    O N N 238 
SER CB   C N N 239 
SER OG   O N N 240 
SER OXT  O N N 241 
SER H    H N N 242 
SER H2   H N N 243 
SER HA   H N N 244 
SER HB2  H N N 245 
SER HB3  H N N 246 
SER HG   H N N 247 
SER HXT  H N N 248 
THR N    N N N 249 
THR CA   C N S 250 
THR C    C N N 251 
THR O    O N N 252 
THR CB   C N R 253 
THR OG1  O N N 254 
THR CG2  C N N 255 
THR OXT  O N N 256 
THR H    H N N 257 
THR H2   H N N 258 
THR HA   H N N 259 
THR HB   H N N 260 
THR HG1  H N N 261 
THR HG21 H N N 262 
THR HG22 H N N 263 
THR HG23 H N N 264 
THR HXT  H N N 265 
TYR N    N N N 266 
TYR CA   C N S 267 
TYR C    C N N 268 
TYR O    O N N 269 
TYR CB   C N N 270 
TYR CG   C Y N 271 
TYR CD1  C Y N 272 
TYR CD2  C Y N 273 
TYR CE1  C Y N 274 
TYR CE2  C Y N 275 
TYR CZ   C Y N 276 
TYR OH   O N N 277 
TYR OXT  O N N 278 
TYR H    H N N 279 
TYR H2   H N N 280 
TYR HA   H N N 281 
TYR HB2  H N N 282 
TYR HB3  H N N 283 
TYR HD1  H N N 284 
TYR HD2  H N N 285 
TYR HE1  H N N 286 
TYR HE2  H N N 287 
TYR HH   H N N 288 
TYR HXT  H N N 289 
VAL N    N N N 290 
VAL CA   C N S 291 
VAL C    C N N 292 
VAL O    O N N 293 
VAL CB   C N N 294 
VAL CG1  C N N 295 
VAL CG2  C N N 296 
VAL OXT  O N N 297 
VAL H    H N N 298 
VAL H2   H N N 299 
VAL HA   H N N 300 
VAL HB   H N N 301 
VAL HG11 H N N 302 
VAL HG12 H N N 303 
VAL HG13 H N N 304 
VAL HG21 H N N 305 
VAL HG22 H N N 306 
VAL HG23 H N N 307 
VAL HXT  H N N 308 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
CYS N   CA   sing N N 55  
CYS N   H    sing N N 56  
CYS N   H2   sing N N 57  
CYS CA  C    sing N N 58  
CYS CA  CB   sing N N 59  
CYS CA  HA   sing N N 60  
CYS C   O    doub N N 61  
CYS C   OXT  sing N N 62  
CYS CB  SG   sing N N 63  
CYS CB  HB2  sing N N 64  
CYS CB  HB3  sing N N 65  
CYS SG  HG   sing N N 66  
CYS OXT HXT  sing N N 67  
GLN N   CA   sing N N 68  
GLN N   H    sing N N 69  
GLN N   H2   sing N N 70  
GLN CA  C    sing N N 71  
GLN CA  CB   sing N N 72  
GLN CA  HA   sing N N 73  
GLN C   O    doub N N 74  
GLN C   OXT  sing N N 75  
GLN CB  CG   sing N N 76  
GLN CB  HB2  sing N N 77  
GLN CB  HB3  sing N N 78  
GLN CG  CD   sing N N 79  
GLN CG  HG2  sing N N 80  
GLN CG  HG3  sing N N 81  
GLN CD  OE1  doub N N 82  
GLN CD  NE2  sing N N 83  
GLN NE2 HE21 sing N N 84  
GLN NE2 HE22 sing N N 85  
GLN OXT HXT  sing N N 86  
GLY N   CA   sing N N 87  
GLY N   H    sing N N 88  
GLY N   H2   sing N N 89  
GLY CA  C    sing N N 90  
GLY CA  HA2  sing N N 91  
GLY CA  HA3  sing N N 92  
GLY C   O    doub N N 93  
GLY C   OXT  sing N N 94  
GLY OXT HXT  sing N N 95  
HIS N   CA   sing N N 96  
HIS N   H    sing N N 97  
HIS N   H2   sing N N 98  
HIS CA  C    sing N N 99  
HIS CA  CB   sing N N 100 
HIS CA  HA   sing N N 101 
HIS C   O    doub N N 102 
HIS C   OXT  sing N N 103 
HIS CB  CG   sing N N 104 
HIS CB  HB2  sing N N 105 
HIS CB  HB3  sing N N 106 
HIS CG  ND1  sing Y N 107 
HIS CG  CD2  doub Y N 108 
HIS ND1 CE1  doub Y N 109 
HIS ND1 HD1  sing N N 110 
HIS CD2 NE2  sing Y N 111 
HIS CD2 HD2  sing N N 112 
HIS CE1 NE2  sing Y N 113 
HIS CE1 HE1  sing N N 114 
HIS NE2 HE2  sing N N 115 
HIS OXT HXT  sing N N 116 
ILE N   CA   sing N N 117 
ILE N   H    sing N N 118 
ILE N   H2   sing N N 119 
ILE CA  C    sing N N 120 
ILE CA  CB   sing N N 121 
ILE CA  HA   sing N N 122 
ILE C   O    doub N N 123 
ILE C   OXT  sing N N 124 
ILE CB  CG1  sing N N 125 
ILE CB  CG2  sing N N 126 
ILE CB  HB   sing N N 127 
ILE CG1 CD1  sing N N 128 
ILE CG1 HG12 sing N N 129 
ILE CG1 HG13 sing N N 130 
ILE CG2 HG21 sing N N 131 
ILE CG2 HG22 sing N N 132 
ILE CG2 HG23 sing N N 133 
ILE CD1 HD11 sing N N 134 
ILE CD1 HD12 sing N N 135 
ILE CD1 HD13 sing N N 136 
ILE OXT HXT  sing N N 137 
LEU N   CA   sing N N 138 
LEU N   H    sing N N 139 
LEU N   H2   sing N N 140 
LEU CA  C    sing N N 141 
LEU CA  CB   sing N N 142 
LEU CA  HA   sing N N 143 
LEU C   O    doub N N 144 
LEU C   OXT  sing N N 145 
LEU CB  CG   sing N N 146 
LEU CB  HB2  sing N N 147 
LEU CB  HB3  sing N N 148 
LEU CG  CD1  sing N N 149 
LEU CG  CD2  sing N N 150 
LEU CG  HG   sing N N 151 
LEU CD1 HD11 sing N N 152 
LEU CD1 HD12 sing N N 153 
LEU CD1 HD13 sing N N 154 
LEU CD2 HD21 sing N N 155 
LEU CD2 HD22 sing N N 156 
LEU CD2 HD23 sing N N 157 
LEU OXT HXT  sing N N 158 
LYS N   CA   sing N N 159 
LYS N   H    sing N N 160 
LYS N   H2   sing N N 161 
LYS CA  C    sing N N 162 
LYS CA  CB   sing N N 163 
LYS CA  HA   sing N N 164 
LYS C   O    doub N N 165 
LYS C   OXT  sing N N 166 
LYS CB  CG   sing N N 167 
LYS CB  HB2  sing N N 168 
LYS CB  HB3  sing N N 169 
LYS CG  CD   sing N N 170 
LYS CG  HG2  sing N N 171 
LYS CG  HG3  sing N N 172 
LYS CD  CE   sing N N 173 
LYS CD  HD2  sing N N 174 
LYS CD  HD3  sing N N 175 
LYS CE  NZ   sing N N 176 
LYS CE  HE2  sing N N 177 
LYS CE  HE3  sing N N 178 
LYS NZ  HZ1  sing N N 179 
LYS NZ  HZ2  sing N N 180 
LYS NZ  HZ3  sing N N 181 
LYS OXT HXT  sing N N 182 
NH2 N   HN1  sing N N 183 
NH2 N   HN2  sing N N 184 
PHE N   CA   sing N N 185 
PHE N   H    sing N N 186 
PHE N   H2   sing N N 187 
PHE CA  C    sing N N 188 
PHE CA  CB   sing N N 189 
PHE CA  HA   sing N N 190 
PHE C   O    doub N N 191 
PHE C   OXT  sing N N 192 
PHE CB  CG   sing N N 193 
PHE CB  HB2  sing N N 194 
PHE CB  HB3  sing N N 195 
PHE CG  CD1  doub Y N 196 
PHE CG  CD2  sing Y N 197 
PHE CD1 CE1  sing Y N 198 
PHE CD1 HD1  sing N N 199 
PHE CD2 CE2  doub Y N 200 
PHE CD2 HD2  sing N N 201 
PHE CE1 CZ   doub Y N 202 
PHE CE1 HE1  sing N N 203 
PHE CE2 CZ   sing Y N 204 
PHE CE2 HE2  sing N N 205 
PHE CZ  HZ   sing N N 206 
PHE OXT HXT  sing N N 207 
PRO N   CA   sing N N 208 
PRO N   CD   sing N N 209 
PRO N   H    sing N N 210 
PRO CA  C    sing N N 211 
PRO CA  CB   sing N N 212 
PRO CA  HA   sing N N 213 
PRO C   O    doub N N 214 
PRO C   OXT  sing N N 215 
PRO CB  CG   sing N N 216 
PRO CB  HB2  sing N N 217 
PRO CB  HB3  sing N N 218 
PRO CG  CD   sing N N 219 
PRO CG  HG2  sing N N 220 
PRO CG  HG3  sing N N 221 
PRO CD  HD2  sing N N 222 
PRO CD  HD3  sing N N 223 
PRO OXT HXT  sing N N 224 
SER N   CA   sing N N 225 
SER N   H    sing N N 226 
SER N   H2   sing N N 227 
SER CA  C    sing N N 228 
SER CA  CB   sing N N 229 
SER CA  HA   sing N N 230 
SER C   O    doub N N 231 
SER C   OXT  sing N N 232 
SER CB  OG   sing N N 233 
SER CB  HB2  sing N N 234 
SER CB  HB3  sing N N 235 
SER OG  HG   sing N N 236 
SER OXT HXT  sing N N 237 
THR N   CA   sing N N 238 
THR N   H    sing N N 239 
THR N   H2   sing N N 240 
THR CA  C    sing N N 241 
THR CA  CB   sing N N 242 
THR CA  HA   sing N N 243 
THR C   O    doub N N 244 
THR C   OXT  sing N N 245 
THR CB  OG1  sing N N 246 
THR CB  CG2  sing N N 247 
THR CB  HB   sing N N 248 
THR OG1 HG1  sing N N 249 
THR CG2 HG21 sing N N 250 
THR CG2 HG22 sing N N 251 
THR CG2 HG23 sing N N 252 
THR OXT HXT  sing N N 253 
TYR N   CA   sing N N 254 
TYR N   H    sing N N 255 
TYR N   H2   sing N N 256 
TYR CA  C    sing N N 257 
TYR CA  CB   sing N N 258 
TYR CA  HA   sing N N 259 
TYR C   O    doub N N 260 
TYR C   OXT  sing N N 261 
TYR CB  CG   sing N N 262 
TYR CB  HB2  sing N N 263 
TYR CB  HB3  sing N N 264 
TYR CG  CD1  doub Y N 265 
TYR CG  CD2  sing Y N 266 
TYR CD1 CE1  sing Y N 267 
TYR CD1 HD1  sing N N 268 
TYR CD2 CE2  doub Y N 269 
TYR CD2 HD2  sing N N 270 
TYR CE1 CZ   doub Y N 271 
TYR CE1 HE1  sing N N 272 
TYR CE2 CZ   sing Y N 273 
TYR CE2 HE2  sing N N 274 
TYR CZ  OH   sing N N 275 
TYR OH  HH   sing N N 276 
TYR OXT HXT  sing N N 277 
VAL N   CA   sing N N 278 
VAL N   H    sing N N 279 
VAL N   H2   sing N N 280 
VAL CA  C    sing N N 281 
VAL CA  CB   sing N N 282 
VAL CA  HA   sing N N 283 
VAL C   O    doub N N 284 
VAL C   OXT  sing N N 285 
VAL CB  CG1  sing N N 286 
VAL CB  CG2  sing N N 287 
VAL CB  HB   sing N N 288 
VAL CG1 HG11 sing N N 289 
VAL CG1 HG12 sing N N 290 
VAL CG1 HG13 sing N N 291 
VAL CG2 HG21 sing N N 292 
VAL CG2 HG22 sing N N 293 
VAL CG2 HG23 sing N N 294 
VAL OXT HXT  sing N N 295 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2023-10-18 
_em_admin.deposition_site    PDBE 
_em_admin.entry_id           8QVR 
_em_admin.last_update        2025-06-04 
_em_admin.map_release_date   2025-06-04 
_em_admin.title              'Cryo-EM structure of human islet amyloid polypeptide (hIAPP) mutant S29P, polymorph 3' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   1 
_em_entity_assembly_recombinant.ncbi_tax_id          32630 
_em_entity_assembly_recombinant.organism             'synthetic construct' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_helical_entity.id                             1 
_em_helical_entity.image_processing_id            1 
_em_helical_entity.details                        ? 
_em_helical_entity.axial_symmetry                 C1 
_em_helical_entity.angular_rotation_per_subunit   -1.98 
_em_helical_entity.axial_rise_per_subunit         4.75 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         58 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       COUNTING 
_em_image_recording.film_or_detector_model              'GATAN K2 QUANTUM (4k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
_em_software.reference_DOI 
'PARTICLE SELECTION'            ? 1  1 ? ? ?       ?       ? 
'IMAGE ACQUISITION'             ? 2  ? ? 1 EPU     2.12.1  ? 
MASKING                         ? 3  ? ? ? ?       ?       ? 
'CTF CORRECTION'                ? 4  1 ? ? CTFFIND ?       ? 
'LAYERLINE INDEXING'            ? 5  ? ? ? ?       ?       ? 
'DIFFRACTION INDEXING'          ? 6  ? ? ? ?       ?       ? 
'MODEL FITTING'                 ? 7  ? 1 ? Coot    0.9.8.8 ? 
OTHER                           ? 8  ? ? ? ?       ?       ? 
'MODEL REFINEMENT'              ? 9  ? 1 ? PHENIX  1.21    ? 
'INITIAL EULER ASSIGNMENT'      ? 10 1 ? ? ?       ?       ? 
'FINAL EULER ASSIGNMENT'        ? 11 1 ? ? ?       ?       ? 
CLASSIFICATION                  ? 12 1 ? ? ?       ?       ? 
RECONSTRUCTION                  ? 13 1 ? ? RELION  4.0.0   ? 
'VOLUME SELECTION'              ? 14 1 1 1 ?       ?       ? 
'SERIES ALIGNMENT'              ? 15 1 1 1 ?       ?       ? 
'MOLECULAR REPLACEMENT'         ? 16 1 1 1 ?       ?       ? 
'LATTICE DISTORTION CORRECTION' ? 17 1 1 1 ?       ?       ? 
'SYMMETRY DETERMINATION'        ? 18 1 1 1 ?       ?       ? 
'CRYSTALLOGRAPHY MERGING'       ? 19 1 1 1 ?       ?       ? 
# 
_em_specimen.concentration           0.4 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'Swedish Research Council' Sweden 'VR 2020-05403'                                   1 
'Other private'            Sweden 'Swedish Society for Medical Research (S20-0156)' 2 
# 
_atom_sites.entry_id                    8QVR 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . CYS A 1 2  ? 118.216 143.168 151.199 1.00 90.80 ? 2  CYS A N   1 
ATOM   2    C CA  . CYS A 1 2  ? 118.806 141.896 150.800 1.00 90.80 ? 2  CYS A CA  1 
ATOM   3    C C   . CYS A 1 2  ? 118.155 140.727 151.531 1.00 90.80 ? 2  CYS A C   1 
ATOM   4    O O   . CYS A 1 2  ? 117.888 140.804 152.729 1.00 90.80 ? 2  CYS A O   1 
ATOM   5    C CB  . CYS A 1 2  ? 120.313 141.901 151.062 1.00 90.80 ? 2  CYS A CB  1 
ATOM   6    S SG  . CYS A 1 2  ? 121.165 143.399 150.526 1.00 90.80 ? 2  CYS A SG  1 
ATOM   7    N N   . ASN A 1 3  ? 117.892 139.647 150.799 1.00 93.76 ? 3  ASN A N   1 
ATOM   8    C CA  . ASN A 1 3  ? 117.324 138.424 151.359 1.00 93.76 ? 3  ASN A CA  1 
ATOM   9    C C   . ASN A 1 3  ? 118.315 137.286 151.146 1.00 93.76 ? 3  ASN A C   1 
ATOM   10   O O   . ASN A 1 3  ? 118.539 136.858 150.008 1.00 93.76 ? 3  ASN A O   1 
ATOM   11   C CB  . ASN A 1 3  ? 115.974 138.104 150.724 1.00 93.76 ? 3  ASN A CB  1 
ATOM   12   C CG  . ASN A 1 3  ? 114.904 139.115 151.088 1.00 93.76 ? 3  ASN A CG  1 
ATOM   13   O OD1 . ASN A 1 3  ? 115.205 140.237 151.491 1.00 93.76 ? 3  ASN A OD1 1 
ATOM   14   N ND2 . ASN A 1 3  ? 113.645 138.717 150.948 1.00 93.76 ? 3  ASN A ND2 1 
ATOM   15   N N   . THR A 1 4  ? 118.893 136.793 152.243 1.00 90.60 ? 4  THR A N   1 
ATOM   16   C CA  . THR A 1 4  ? 119.846 135.678 152.224 1.00 90.60 ? 4  THR A CA  1 
ATOM   17   C C   . THR A 1 4  ? 120.979 135.931 151.230 1.00 90.60 ? 4  THR A C   1 
ATOM   18   O O   . THR A 1 4  ? 121.456 135.018 150.554 1.00 90.60 ? 4  THR A O   1 
ATOM   19   C CB  . THR A 1 4  ? 119.153 134.350 151.908 1.00 90.60 ? 4  THR A CB  1 
ATOM   20   O OG1 . THR A 1 4  ? 119.053 134.201 150.491 1.00 90.60 ? 4  THR A OG1 1 
ATOM   21   C CG2 . THR A 1 4  ? 117.752 134.298 152.500 1.00 90.60 ? 4  THR A CG2 1 
ATOM   22   N N   . ALA A 1 5  ? 121.417 137.186 151.144 1.00 84.35 ? 5  ALA A N   1 
ATOM   23   C CA  . ALA A 1 5  ? 122.327 137.612 150.089 1.00 84.35 ? 5  ALA A CA  1 
ATOM   24   C C   . ALA A 1 5  ? 123.441 138.466 150.674 1.00 84.35 ? 5  ALA A C   1 
ATOM   25   O O   . ALA A 1 5  ? 123.170 139.498 151.293 1.00 84.35 ? 5  ALA A O   1 
ATOM   26   C CB  . ALA A 1 5  ? 121.571 138.392 149.012 1.00 84.35 ? 5  ALA A CB  1 
ATOM   27   N N   . THR A 1 6  ? 124.687 138.056 150.454 1.00 78.58 ? 6  THR A N   1 
ATOM   28   C CA  . THR A 1 6  ? 125.836 138.866 150.848 1.00 78.58 ? 6  THR A CA  1 
ATOM   29   C C   . THR A 1 6  ? 125.950 140.048 149.895 1.00 78.58 ? 6  THR A C   1 
ATOM   30   O O   . THR A 1 6  ? 126.359 139.887 148.743 1.00 78.58 ? 6  THR A O   1 
ATOM   31   C CB  . THR A 1 6  ? 127.108 138.025 150.834 1.00 78.58 ? 6  THR A CB  1 
ATOM   32   O OG1 . THR A 1 6  ? 127.581 137.902 149.488 1.00 78.58 ? 6  THR A OG1 1 
ATOM   33   C CG2 . THR A 1 6  ? 126.832 136.637 151.387 1.00 78.58 ? 6  THR A CG2 1 
ATOM   34   N N   . CYS A 1 7  ? 125.604 141.240 150.372 1.00 81.23 ? 7  CYS A N   1 
ATOM   35   C CA  . CYS A 1 7  ? 125.398 142.404 149.513 1.00 81.23 ? 7  CYS A CA  1 
ATOM   36   C C   . CYS A 1 7  ? 126.263 143.575 149.963 1.00 81.23 ? 7  CYS A C   1 
ATOM   37   O O   . CYS A 1 7  ? 125.777 144.684 150.203 1.00 81.23 ? 7  CYS A O   1 
ATOM   38   C CB  . CYS A 1 7  ? 123.926 142.796 149.457 1.00 81.23 ? 7  CYS A CB  1 
ATOM   39   S SG  . CYS A 1 7  ? 123.104 143.057 151.021 1.00 81.23 ? 7  CYS A SG  1 
ATOM   40   N N   . ALA A 1 8  ? 127.563 143.323 150.112 1.00 73.82 ? 8  ALA A N   1 
ATOM   41   C CA  . ALA A 1 8  ? 128.504 144.366 150.503 1.00 73.82 ? 8  ALA A CA  1 
ATOM   42   C C   . ALA A 1 8  ? 128.428 145.567 149.566 1.00 73.82 ? 8  ALA A C   1 
ATOM   43   O O   . ALA A 1 8  ? 128.408 145.416 148.342 1.00 73.82 ? 8  ALA A O   1 
ATOM   44   C CB  . ALA A 1 8  ? 129.924 143.806 150.517 1.00 73.82 ? 8  ALA A CB  1 
ATOM   45   N N   . THR A 1 9  ? 128.384 146.766 150.146 1.00 70.04 ? 9  THR A N   1 
ATOM   46   C CA  . THR A 1 9  ? 128.270 148.002 149.388 1.00 70.04 ? 9  THR A CA  1 
ATOM   47   C C   . THR A 1 9  ? 129.182 149.065 149.985 1.00 70.04 ? 9  THR A C   1 
ATOM   48   O O   . THR A 1 9  ? 129.418 149.088 151.195 1.00 70.04 ? 9  THR A O   1 
ATOM   49   C CB  . THR A 1 9  ? 126.823 148.515 149.377 1.00 70.04 ? 9  THR A CB  1 
ATOM   50   O OG1 . THR A 1 9  ? 125.928 147.417 149.165 1.00 70.04 ? 9  THR A OG1 1 
ATOM   51   C CG2 . THR A 1 9  ? 126.622 149.540 148.273 1.00 70.04 ? 9  THR A CG2 1 
ATOM   52   N N   . GLN A 1 10 ? 129.705 149.943 149.129 1.00 63.39 ? 10 GLN A N   1 
ATOM   53   C CA  . GLN A 1 10 ? 130.369 151.152 149.591 1.00 63.39 ? 10 GLN A CA  1 
ATOM   54   C C   . GLN A 1 10 ? 129.947 152.324 148.723 1.00 63.39 ? 10 GLN A C   1 
ATOM   55   O O   . GLN A 1 10 ? 129.514 152.149 147.583 1.00 63.39 ? 10 GLN A O   1 
ATOM   56   C CB  . GLN A 1 10 ? 131.900 151.043 149.591 1.00 63.39 ? 10 GLN A CB  1 
ATOM   57   C CG  . GLN A 1 10 ? 132.506 150.088 148.594 1.00 63.39 ? 10 GLN A CG  1 
ATOM   58   C CD  . GLN A 1 10 ? 134.010 150.005 148.758 1.00 63.39 ? 10 GLN A CD  1 
ATOM   59   O OE1 . GLN A 1 10 ? 134.595 150.732 149.560 1.00 63.39 ? 10 GLN A OE1 1 
ATOM   60   N NE2 . GLN A 1 10 ? 134.645 149.129 147.997 1.00 63.39 ? 10 GLN A NE2 1 
ATOM   61   N N   . ARG A 1 11 ? 130.062 153.525 149.282 1.00 65.50 ? 11 ARG A N   1 
ATOM   62   C CA  . ARG A 1 11 ? 129.669 154.744 148.593 1.00 65.50 ? 11 ARG A CA  1 
ATOM   63   C C   . ARG A 1 11 ? 130.641 155.863 148.933 1.00 65.50 ? 11 ARG A C   1 
ATOM   64   O O   . ARG A 1 11 ? 131.021 156.034 150.094 1.00 65.50 ? 11 ARG A O   1 
ATOM   65   C CB  . ARG A 1 11 ? 128.245 155.165 148.969 1.00 65.50 ? 11 ARG A CB  1 
ATOM   66   C CG  . ARG A 1 11 ? 127.158 154.330 148.324 1.00 65.50 ? 11 ARG A CG  1 
ATOM   67   C CD  . ARG A 1 11 ? 125.788 154.943 148.559 1.00 65.50 ? 11 ARG A CD  1 
ATOM   68   N NE  . ARG A 1 11 ? 124.732 154.208 147.871 1.00 65.50 ? 11 ARG A NE  1 
ATOM   69   C CZ  . ARG A 1 11 ? 123.460 154.575 147.847 1.00 65.50 ? 11 ARG A CZ  1 
ATOM   70   N NH1 . ARG A 1 11 ? 123.046 155.673 148.458 1.00 65.50 ? 11 ARG A NH1 1 
ATOM   71   N NH2 . ARG A 1 11 ? 122.579 153.824 147.191 1.00 65.50 ? 11 ARG A NH2 1 
ATOM   72   N N   . LEU A 1 12 ? 131.039 156.615 147.913 1.00 64.37 ? 12 LEU A N   1 
ATOM   73   C CA  . LEU A 1 12 ? 131.834 157.824 148.075 1.00 64.37 ? 12 LEU A CA  1 
ATOM   74   C C   . LEU A 1 12 ? 131.141 158.937 147.306 1.00 64.37 ? 12 LEU A C   1 
ATOM   75   O O   . LEU A 1 12 ? 130.803 158.757 146.133 1.00 64.37 ? 12 LEU A O   1 
ATOM   76   C CB  . LEU A 1 12 ? 133.266 157.625 147.566 1.00 64.37 ? 12 LEU A CB  1 
ATOM   77   C CG  . LEU A 1 12 ? 134.184 156.698 148.366 1.00 64.37 ? 12 LEU A CG  1 
ATOM   78   C CD1 . LEU A 1 12 ? 134.002 155.252 147.952 1.00 64.37 ? 12 LEU A CD1 1 
ATOM   79   C CD2 . LEU A 1 12 ? 135.632 157.111 148.194 1.00 64.37 ? 12 LEU A CD2 1 
ATOM   80   N N   . ALA A 1 13 ? 130.917 160.077 147.956 1.00 70.00 ? 13 ALA A N   1 
ATOM   81   C CA  . ALA A 1 13 ? 130.128 161.116 147.312 1.00 70.00 ? 13 ALA A CA  1 
ATOM   82   C C   . ALA A 1 13 ? 130.483 162.484 147.873 1.00 70.00 ? 13 ALA A C   1 
ATOM   83   O O   . ALA A 1 13 ? 130.937 162.615 149.012 1.00 70.00 ? 13 ALA A O   1 
ATOM   84   C CB  . ALA A 1 13 ? 128.629 160.852 147.471 1.00 70.00 ? 13 ALA A CB  1 
ATOM   85   N N   . ASN A 1 14 ? 130.263 163.502 147.040 1.00 73.26 ? 14 ASN A N   1 
ATOM   86   C CA  . ASN A 1 14 ? 130.311 164.909 147.435 1.00 73.26 ? 14 ASN A CA  1 
ATOM   87   C C   . ASN A 1 14 ? 131.621 165.272 148.127 1.00 73.26 ? 14 ASN A C   1 
ATOM   88   O O   . ASN A 1 14 ? 131.643 165.972 149.140 1.00 73.26 ? 14 ASN A O   1 
ATOM   89   C CB  . ASN A 1 14 ? 129.114 165.259 148.317 1.00 73.26 ? 14 ASN A CB  1 
ATOM   90   C CG  . ASN A 1 14 ? 127.802 164.782 147.732 1.00 73.26 ? 14 ASN A CG  1 
ATOM   91   O OD1 . ASN A 1 14 ? 127.310 165.336 146.749 1.00 73.26 ? 14 ASN A OD1 1 
ATOM   92   N ND2 . ASN A 1 14 ? 127.224 163.751 148.335 1.00 73.26 ? 14 ASN A ND2 1 
ATOM   93   N N   . PHE A 1 15 ? 132.730 164.805 147.565 1.00 71.42 ? 15 PHE A N   1 
ATOM   94   C CA  . PHE A 1 15 ? 134.035 165.072 148.150 1.00 71.42 ? 15 PHE A CA  1 
ATOM   95   C C   . PHE A 1 15 ? 134.953 165.723 147.126 1.00 71.42 ? 15 PHE A C   1 
ATOM   96   O O   . PHE A 1 15 ? 134.598 165.904 145.961 1.00 71.42 ? 15 PHE A O   1 
ATOM   97   C CB  . PHE A 1 15 ? 134.673 163.796 148.710 1.00 71.42 ? 15 PHE A CB  1 
ATOM   98   C CG  . PHE A 1 15 ? 134.950 162.742 147.681 1.00 71.42 ? 15 PHE A CG  1 
ATOM   99   C CD1 . PHE A 1 15 ? 133.968 161.839 147.316 1.00 71.42 ? 15 PHE A CD1 1 
ATOM   100  C CD2 . PHE A 1 15 ? 136.200 162.636 147.101 1.00 71.42 ? 15 PHE A CD2 1 
ATOM   101  C CE1 . PHE A 1 15 ? 134.224 160.858 146.379 1.00 71.42 ? 15 PHE A CE1 1 
ATOM   102  C CE2 . PHE A 1 15 ? 136.463 161.660 146.162 1.00 71.42 ? 15 PHE A CE2 1 
ATOM   103  C CZ  . PHE A 1 15 ? 135.474 160.770 145.803 1.00 71.42 ? 15 PHE A CZ  1 
ATOM   104  N N   . LEU A 1 16 ? 136.143 166.100 147.590 1.00 72.35 ? 16 LEU A N   1 
ATOM   105  C CA  . LEU A 1 16 ? 137.163 166.706 146.744 1.00 72.35 ? 16 LEU A CA  1 
ATOM   106  C C   . LEU A 1 16 ? 138.525 166.234 147.219 1.00 72.35 ? 16 LEU A C   1 
ATOM   107  O O   . LEU A 1 16 ? 138.842 166.343 148.407 1.00 72.35 ? 16 LEU A O   1 
ATOM   108  C CB  . LEU A 1 16 ? 137.094 168.237 146.783 1.00 72.35 ? 16 LEU A CB  1 
ATOM   109  C CG  . LEU A 1 16 ? 135.898 168.916 146.117 1.00 72.35 ? 16 LEU A CG  1 
ATOM   110  C CD1 . LEU A 1 16 ? 134.800 169.195 147.132 1.00 72.35 ? 16 LEU A CD1 1 
ATOM   111  C CD2 . LEU A 1 16 ? 136.330 170.197 145.423 1.00 72.35 ? 16 LEU A CD2 1 
ATOM   112  N N   . VAL A 1 17 ? 139.328 165.717 146.297 1.00 69.22 ? 17 VAL A N   1 
ATOM   113  C CA  . VAL A 1 17 ? 140.663 165.221 146.604 1.00 69.22 ? 17 VAL A CA  1 
ATOM   114  C C   . VAL A 1 17 ? 141.639 166.021 145.755 1.00 69.22 ? 17 VAL A C   1 
ATOM   115  O O   . VAL A 1 17 ? 141.530 166.051 144.524 1.00 69.22 ? 17 VAL A O   1 
ATOM   116  C CB  . VAL A 1 17 ? 140.802 163.717 146.346 1.00 69.22 ? 17 VAL A CB  1 
ATOM   117  C CG1 . VAL A 1 17 ? 142.224 163.266 146.616 1.00 69.22 ? 17 VAL A CG1 1 
ATOM   118  C CG2 . VAL A 1 17 ? 139.827 162.946 147.213 1.00 69.22 ? 17 VAL A CG2 1 
ATOM   119  N N   . HIS A 1 18 ? 142.590 166.681 146.404 1.00 73.46 ? 18 HIS A N   1 
ATOM   120  C CA  . HIS A 1 18 ? 143.625 167.435 145.711 1.00 73.46 ? 18 HIS A CA  1 
ATOM   121  C C   . HIS A 1 18 ? 144.981 166.833 146.048 1.00 73.46 ? 18 HIS A C   1 
ATOM   122  O O   . HIS A 1 18 ? 145.317 166.668 147.225 1.00 73.46 ? 18 HIS A O   1 
ATOM   123  C CB  . HIS A 1 18 ? 143.567 168.910 146.106 1.00 73.46 ? 18 HIS A CB  1 
ATOM   124  C CG  . HIS A 1 18 ? 144.408 169.800 145.244 1.00 73.46 ? 18 HIS A CG  1 
ATOM   125  N ND1 . HIS A 1 18 ? 145.783 169.731 145.218 1.00 73.46 ? 18 HIS A ND1 1 
ATOM   126  C CD2 . HIS A 1 18 ? 144.063 170.780 144.376 1.00 73.46 ? 18 HIS A CD2 1 
ATOM   127  C CE1 . HIS A 1 18 ? 146.252 170.631 144.371 1.00 73.46 ? 18 HIS A CE1 1 
ATOM   128  N NE2 . HIS A 1 18 ? 145.227 171.280 143.848 1.00 73.46 ? 18 HIS A NE2 1 
ATOM   129  N N   . SER A 1 19 ? 145.759 166.507 145.021 1.00 68.99 ? 19 SER A N   1 
ATOM   130  C CA  . SER A 1 19 ? 147.066 165.900 145.200 1.00 68.99 ? 19 SER A CA  1 
ATOM   131  C C   . SER A 1 19 ? 148.101 166.656 144.383 1.00 68.99 ? 19 SER A C   1 
ATOM   132  O O   . SER A 1 19 ? 147.792 167.232 143.338 1.00 68.99 ? 19 SER A O   1 
ATOM   133  C CB  . SER A 1 19 ? 147.062 164.424 144.795 1.00 68.99 ? 19 SER A CB  1 
ATOM   134  O OG  . SER A 1 19 ? 148.348 163.853 144.956 1.00 68.99 ? 19 SER A OG  1 
ATOM   135  N N   . SER A 1 20 ? 149.338 166.650 144.874 1.00 71.47 ? 20 SER A N   1 
ATOM   136  C CA  . SER A 1 20 ? 150.444 167.329 144.212 1.00 71.47 ? 20 SER A CA  1 
ATOM   137  C C   . SER A 1 20 ? 151.509 166.359 143.727 1.00 71.47 ? 20 SER A C   1 
ATOM   138  O O   . SER A 1 20 ? 151.980 166.479 142.591 1.00 71.47 ? 20 SER A O   1 
ATOM   139  C CB  . SER A 1 20 ? 151.064 168.367 145.157 1.00 71.47 ? 20 SER A CB  1 
ATOM   140  O OG  . SER A 1 20 ? 150.105 169.335 145.542 1.00 71.47 ? 20 SER A OG  1 
ATOM   141  N N   . ASN A 1 21 ? 151.917 165.412 144.565 1.00 71.76 ? 21 ASN A N   1 
ATOM   142  C CA  . ASN A 1 21 ? 152.811 164.336 144.168 1.00 71.76 ? 21 ASN A CA  1 
ATOM   143  C C   . ASN A 1 21 ? 152.307 163.053 144.806 1.00 71.76 ? 21 ASN A C   1 
ATOM   144  O O   . ASN A 1 21 ? 151.877 163.066 145.963 1.00 71.76 ? 21 ASN A O   1 
ATOM   145  C CB  . ASN A 1 21 ? 154.253 164.617 144.595 1.00 71.76 ? 21 ASN A CB  1 
ATOM   146  C CG  . ASN A 1 21 ? 155.231 163.610 144.033 1.00 71.76 ? 21 ASN A CG  1 
ATOM   147  O OD1 . ASN A 1 21 ? 155.485 162.568 144.638 1.00 71.76 ? 21 ASN A OD1 1 
ATOM   148  N ND2 . ASN A 1 21 ? 155.799 163.921 142.875 1.00 71.76 ? 21 ASN A ND2 1 
ATOM   149  N N   . ASN A 1 22 ? 152.353 161.952 144.063 1.00 73.01 ? 22 ASN A N   1 
ATOM   150  C CA  . ASN A 1 22 ? 151.827 160.695 144.571 1.00 73.01 ? 22 ASN A CA  1 
ATOM   151  C C   . ASN A 1 22 ? 152.558 159.523 143.936 1.00 73.01 ? 22 ASN A C   1 
ATOM   152  O O   . ASN A 1 22 ? 152.842 159.526 142.736 1.00 73.01 ? 22 ASN A O   1 
ATOM   153  C CB  . ASN A 1 22 ? 150.324 160.573 144.311 1.00 73.01 ? 22 ASN A CB  1 
ATOM   154  C CG  . ASN A 1 22 ? 149.801 159.189 144.616 1.00 73.01 ? 22 ASN A CG  1 
ATOM   155  O OD1 . ASN A 1 22 ? 149.547 158.850 145.769 1.00 73.01 ? 22 ASN A OD1 1 
ATOM   156  N ND2 . ASN A 1 22 ? 149.643 158.377 143.580 1.00 73.01 ? 22 ASN A ND2 1 
ATOM   157  N N   . PHE A 1 23 ? 152.853 158.518 144.758 1.00 75.52 ? 23 PHE A N   1 
ATOM   158  C CA  . PHE A 1 23 ? 153.491 157.292 144.297 1.00 75.52 ? 23 PHE A CA  1 
ATOM   159  C C   . PHE A 1 23 ? 152.640 156.047 144.487 1.00 75.52 ? 23 PHE A C   1 
ATOM   160  O O   . PHE A 1 23 ? 153.062 154.968 144.053 1.00 75.52 ? 23 PHE A O   1 
ATOM   161  C CB  . PHE A 1 23 ? 154.835 157.078 145.009 1.00 75.52 ? 23 PHE A CB  1 
ATOM   162  C CG  . PHE A 1 23 ? 155.982 157.831 144.394 1.00 75.52 ? 23 PHE A CG  1 
ATOM   163  C CD1 . PHE A 1 23 ? 155.767 159.000 143.687 1.00 75.52 ? 23 PHE A CD1 1 
ATOM   164  C CD2 . PHE A 1 23 ? 157.280 157.368 144.532 1.00 75.52 ? 23 PHE A CD2 1 
ATOM   165  C CE1 . PHE A 1 23 ? 156.820 159.693 143.128 1.00 75.52 ? 23 PHE A CE1 1 
ATOM   166  C CE2 . PHE A 1 23 ? 158.337 158.056 143.974 1.00 75.52 ? 23 PHE A CE2 1 
ATOM   167  C CZ  . PHE A 1 23 ? 158.106 159.220 143.270 1.00 75.52 ? 23 PHE A CZ  1 
ATOM   168  N N   . GLY A 1 24 ? 151.478 156.146 145.128 1.00 76.04 ? 24 GLY A N   1 
ATOM   169  C CA  . GLY A 1 24 ? 150.606 155.004 145.321 1.00 76.04 ? 24 GLY A CA  1 
ATOM   170  C C   . GLY A 1 24 ? 149.162 155.319 145.000 1.00 76.04 ? 24 GLY A C   1 
ATOM   171  O O   . GLY A 1 24 ? 148.869 156.358 144.403 1.00 76.04 ? 24 GLY A O   1 
ATOM   172  N N   . ALA A 1 25 ? 148.248 154.432 145.384 1.00 73.14 ? 25 ALA A N   1 
ATOM   173  C CA  . ALA A 1 25 ? 146.830 154.676 145.163 1.00 73.14 ? 25 ALA A CA  1 
ATOM   174  C C   . ALA A 1 25 ? 146.353 155.842 146.018 1.00 73.14 ? 25 ALA A C   1 
ATOM   175  O O   . ALA A 1 25 ? 146.906 156.122 147.080 1.00 73.14 ? 25 ALA A O   1 
ATOM   176  C CB  . ALA A 1 25 ? 146.017 153.426 145.485 1.00 73.14 ? 25 ALA A CB  1 
ATOM   177  N N   . ILE A 1 26 ? 145.332 156.551 145.535 1.00 73.31 ? 26 ILE A N   1 
ATOM   178  C CA  . ILE A 1 26 ? 144.722 157.577 146.370 1.00 73.31 ? 26 ILE A CA  1 
ATOM   179  C C   . ILE A 1 26 ? 143.231 157.311 146.504 1.00 73.31 ? 26 ILE A C   1 
ATOM   180  O O   . ILE A 1 26 ? 142.617 157.689 147.505 1.00 73.31 ? 26 ILE A O   1 
ATOM   181  C CB  . ILE A 1 26 ? 144.984 159.002 145.842 1.00 73.31 ? 26 ILE A CB  1 
ATOM   182  C CG1 . ILE A 1 26 ? 144.008 159.368 144.727 1.00 73.31 ? 26 ILE A CG1 1 
ATOM   183  C CG2 . ILE A 1 26 ? 146.413 159.150 145.360 1.00 73.31 ? 26 ILE A CG2 1 
ATOM   184  C CD1 . ILE A 1 26 ? 144.020 160.835 144.373 1.00 73.31 ? 26 ILE A CD1 1 
ATOM   185  N N   . LEU A 1 27 ? 142.630 156.654 145.510 1.00 69.27 ? 27 LEU A N   1 
ATOM   186  C CA  . LEU A 1 27 ? 141.244 156.206 145.654 1.00 69.27 ? 27 LEU A CA  1 
ATOM   187  C C   . LEU A 1 27 ? 141.123 154.855 144.945 1.00 69.27 ? 27 LEU A C   1 
ATOM   188  O O   . LEU A 1 27 ? 140.799 154.792 143.759 1.00 69.27 ? 27 LEU A O   1 
ATOM   189  C CB  . LEU A 1 27 ? 140.251 157.214 145.094 1.00 69.27 ? 27 LEU A CB  1 
ATOM   190  C CG  . LEU A 1 27 ? 139.711 158.309 146.016 1.00 69.27 ? 27 LEU A CG  1 
ATOM   191  C CD1 . LEU A 1 27 ? 140.584 159.545 145.954 1.00 69.27 ? 27 LEU A CD1 1 
ATOM   192  C CD2 . LEU A 1 27 ? 138.280 158.648 145.660 1.00 69.27 ? 27 LEU A CD2 1 
ATOM   193  N N   . SER A 1 28 ? 141.359 153.782 145.691 1.00 69.58 ? 28 SER A N   1 
ATOM   194  C CA  . SER A 1 28 ? 141.199 152.421 145.179 1.00 69.58 ? 28 SER A CA  1 
ATOM   195  C C   . SER A 1 28 ? 140.488 151.570 146.221 1.00 69.58 ? 28 SER A C   1 
ATOM   196  O O   . SER A 1 28 ? 141.072 150.642 146.792 1.00 69.58 ? 28 SER A O   1 
ATOM   197  C CB  . SER A 1 28 ? 142.552 151.822 144.800 1.00 69.58 ? 28 SER A CB  1 
ATOM   198  O OG  . SER A 1 28 ? 143.267 152.701 143.952 1.00 69.58 ? 28 SER A OG  1 
ATOM   199  N N   . PRO A 1 29 ? 139.220 151.863 146.497 1.00 65.34 ? 29 PRO A N   1 
ATOM   200  C CA  . PRO A 1 29 ? 138.474 151.019 147.430 1.00 65.34 ? 29 PRO A CA  1 
ATOM   201  C C   . PRO A 1 29 ? 138.263 149.630 146.853 1.00 65.34 ? 29 PRO A C   1 
ATOM   202  O O   . PRO A 1 29 ? 138.147 149.454 145.640 1.00 65.34 ? 29 PRO A O   1 
ATOM   203  C CB  . PRO A 1 29 ? 137.147 151.766 147.603 1.00 65.34 ? 29 PRO A CB  1 
ATOM   204  C CG  . PRO A 1 29 ? 137.007 152.566 146.374 1.00 65.34 ? 29 PRO A CG  1 
ATOM   205  C CD  . PRO A 1 29 ? 138.390 152.950 145.955 1.00 65.34 ? 29 PRO A CD  1 
ATOM   206  N N   . THR A 1 30 ? 138.222 148.638 147.736 1.00 65.63 ? 30 THR A N   1 
ATOM   207  C CA  . THR A 1 30 ? 138.030 147.249 147.351 1.00 65.63 ? 30 THR A CA  1 
ATOM   208  C C   . THR A 1 30 ? 136.701 146.760 147.899 1.00 65.63 ? 30 THR A C   1 
ATOM   209  O O   . THR A 1 30 ? 136.439 146.881 149.100 1.00 65.63 ? 30 THR A O   1 
ATOM   210  C CB  . THR A 1 30 ? 139.170 146.367 147.865 1.00 65.63 ? 30 THR A CB  1 
ATOM   211  O OG1 . THR A 1 30 ? 140.417 146.843 147.345 1.00 65.63 ? 30 THR A OG1 1 
ATOM   212  C CG2 . THR A 1 30 ? 138.966 144.927 147.433 1.00 65.63 ? 30 THR A CG2 1 
ATOM   213  N N   . ASN A 1 31 ? 135.866 146.212 147.022 1.00 62.46 ? 31 ASN A N   1 
ATOM   214  C CA  . ASN A 1 31 ? 134.567 145.675 147.403 1.00 62.46 ? 31 ASN A CA  1 
ATOM   215  C C   . ASN A 1 31 ? 134.498 144.225 146.955 1.00 62.46 ? 31 ASN A C   1 
ATOM   216  O O   . ASN A 1 31 ? 134.638 143.938 145.762 1.00 62.46 ? 31 ASN A O   1 
ATOM   217  C CB  . ASN A 1 31 ? 133.429 146.483 146.780 1.00 62.46 ? 31 ASN A CB  1 
ATOM   218  C CG  . ASN A 1 31 ? 132.083 146.128 147.361 1.00 62.46 ? 31 ASN A CG  1 
ATOM   219  O OD1 . ASN A 1 31 ? 131.995 145.467 148.393 1.00 62.46 ? 31 ASN A OD1 1 
ATOM   220  N ND2 . ASN A 1 31 ? 131.023 146.571 146.705 1.00 62.46 ? 31 ASN A ND2 1 
ATOM   221  N N   . VAL A 1 32 ? 134.287 143.320 147.902 1.00 60.49 ? 32 VAL A N   1 
ATOM   222  C CA  . VAL A 1 32 ? 134.186 141.895 147.617 1.00 60.49 ? 32 VAL A CA  1 
ATOM   223  C C   . VAL A 1 32 ? 132.900 141.375 148.234 1.00 60.49 ? 32 VAL A C   1 
ATOM   224  O O   . VAL A 1 32 ? 132.702 141.484 149.449 1.00 60.49 ? 32 VAL A O   1 
ATOM   225  C CB  . VAL A 1 32 ? 135.402 141.117 148.154 1.00 60.49 ? 32 VAL A CB  1 
ATOM   226  C CG1 . VAL A 1 32 ? 135.150 139.623 148.075 1.00 60.49 ? 32 VAL A CG1 1 
ATOM   227  C CG2 . VAL A 1 32 ? 136.652 141.493 147.382 1.00 60.49 ? 32 VAL A CG2 1 
ATOM   228  N N   . GLY A 1 33 ? 132.023 140.818 147.399 1.00 61.00 ? 33 GLY A N   1 
ATOM   229  C CA  . GLY A 1 33 ? 130.780 140.270 147.910 1.00 61.00 ? 33 GLY A CA  1 
ATOM   230  C C   . GLY A 1 33 ? 130.994 139.061 148.798 1.00 61.00 ? 33 GLY A C   1 
ATOM   231  O O   . GLY A 1 33 ? 130.353 138.926 149.842 1.00 61.00 ? 33 GLY A O   1 
ATOM   232  N N   . SER A 1 34 ? 131.892 138.166 148.397 1.00 59.91 ? 34 SER A N   1 
ATOM   233  C CA  . SER A 1 34 ? 132.181 136.970 149.173 1.00 59.91 ? 34 SER A CA  1 
ATOM   234  C C   . SER A 1 34 ? 133.495 136.378 148.694 1.00 59.91 ? 34 SER A C   1 
ATOM   235  O O   . SER A 1 34 ? 133.852 136.494 147.519 1.00 59.91 ? 34 SER A O   1 
ATOM   236  C CB  . SER A 1 34 ? 131.059 135.936 149.051 1.00 59.91 ? 34 SER A CB  1 
ATOM   237  O OG  . SER A 1 34 ? 130.941 135.474 147.719 1.00 59.91 ? 34 SER A OG  1 
ATOM   238  N N   . ASN A 1 35 ? 134.212 135.743 149.619 1.00 64.80 ? 35 ASN A N   1 
ATOM   239  C CA  . ASN A 1 35 ? 135.482 135.081 149.329 1.00 64.80 ? 35 ASN A CA  1 
ATOM   240  C C   . ASN A 1 35 ? 135.415 133.667 149.898 1.00 64.80 ? 35 ASN A C   1 
ATOM   241  O O   . ASN A 1 35 ? 135.424 133.480 151.118 1.00 64.80 ? 35 ASN A O   1 
ATOM   242  C CB  . ASN A 1 35 ? 136.657 135.853 149.910 1.00 64.80 ? 35 ASN A CB  1 
ATOM   243  C CG  . ASN A 1 35 ? 137.986 135.361 149.383 1.00 64.80 ? 35 ASN A CG  1 
ATOM   244  O OD1 . ASN A 1 35 ? 138.054 134.375 148.654 1.00 64.80 ? 35 ASN A OD1 1 
ATOM   245  N ND2 . ASN A 1 35 ? 139.056 136.033 149.773 1.00 64.80 ? 35 ASN A ND2 1 
ATOM   246  N N   . THR A 1 36 ? 135.345 132.677 149.018 1.00 67.27 ? 36 THR A N   1 
ATOM   247  C CA  . THR A 1 36 ? 135.323 131.279 149.427 1.00 67.27 ? 36 THR A CA  1 
ATOM   248  C C   . THR A 1 36 ? 136.701 130.677 149.188 1.00 67.27 ? 36 THR A C   1 
ATOM   249  O O   . THR A 1 36 ? 137.247 130.770 148.084 1.00 67.27 ? 36 THR A O   1 
ATOM   250  C CB  . THR A 1 36 ? 134.244 130.509 148.669 1.00 67.27 ? 36 THR A CB  1 
ATOM   251  O OG1 . THR A 1 36 ? 132.955 131.008 149.038 1.00 67.27 ? 36 THR A OG1 1 
ATOM   252  C CG2 . THR A 1 36 ? 134.321 129.028 148.999 1.00 67.27 ? 36 THR A CG2 1 
ATOM   253  N N   . TYR A 1 37 ? 137.265 130.069 150.224 1.00 68.49 ? 37 TYR A N   1 
ATOM   254  C CA  . TYR A 1 37 ? 138.530 129.352 150.122 1.00 68.49 ? 37 TYR A CA  1 
ATOM   255  C C   . TYR A 1 37 ? 138.386 127.968 150.742 1.00 68.49 ? 37 TYR A C   1 
ATOM   256  O O   . TYR A 1 37 ? 139.181 127.571 151.592 1.00 68.49 ? 37 TYR A O   1 
ATOM   257  C CB  . TYR A 1 37 ? 139.652 130.134 150.804 1.00 68.49 ? 37 TYR A CB  1 
ATOM   258  C CG  . TYR A 1 37 ? 141.050 129.725 150.399 1.00 68.49 ? 37 TYR A CG  1 
ATOM   259  C CD1 . TYR A 1 37 ? 141.265 128.663 149.532 1.00 68.49 ? 37 TYR A CD1 1 
ATOM   260  C CD2 . TYR A 1 37 ? 142.156 130.390 150.898 1.00 68.49 ? 37 TYR A CD2 1 
ATOM   261  C CE1 . TYR A 1 37 ? 142.541 128.283 149.172 1.00 68.49 ? 37 TYR A CE1 1 
ATOM   262  C CE2 . TYR A 1 37 ? 143.433 130.017 150.541 1.00 68.49 ? 37 TYR A CE2 1 
ATOM   263  C CZ  . TYR A 1 37 ? 143.622 128.965 149.679 1.00 68.49 ? 37 TYR A CZ  1 
ATOM   264  O OH  . TYR A 1 37 ? 144.896 128.592 149.323 1.00 68.49 ? 37 TYR A OH  1 
HETATM 265  N N   . NH2 A 1 38 ? 137.362 127.237 150.312 1.00 69.60 ? 38 NH2 A N   1 
ATOM   266  N N   . ALA B 1 13 ? 167.380 129.817 146.797 1.00 44.34 ? 13 ALA B N   1 
ATOM   267  C CA  . ALA B 1 13 ? 166.234 130.242 146.005 1.00 44.34 ? 13 ALA B CA  1 
ATOM   268  C C   . ALA B 1 13 ? 165.441 131.321 146.733 1.00 44.34 ? 13 ALA B C   1 
ATOM   269  O O   . ALA B 1 13 ? 164.615 131.020 147.590 1.00 44.34 ? 13 ALA B O   1 
ATOM   270  C CB  . ALA B 1 13 ? 165.343 129.059 145.684 1.00 44.34 ? 13 ALA B CB  1 
ATOM   271  N N   . ASN B 1 14 ? 165.696 132.577 146.386 1.00 45.28 ? 14 ASN B N   1 
ATOM   272  C CA  . ASN B 1 14 ? 165.034 133.693 147.043 1.00 45.28 ? 14 ASN B CA  1 
ATOM   273  C C   . ASN B 1 14 ? 163.680 133.965 146.403 1.00 45.28 ? 14 ASN B C   1 
ATOM   274  O O   . ASN B 1 14 ? 163.539 133.941 145.179 1.00 45.28 ? 14 ASN B O   1 
ATOM   275  C CB  . ASN B 1 14 ? 165.904 134.946 146.973 1.00 45.28 ? 14 ASN B CB  1 
ATOM   276  C CG  . ASN B 1 14 ? 167.294 134.715 147.522 1.00 45.28 ? 14 ASN B CG  1 
ATOM   277  O OD1 . ASN B 1 14 ? 167.767 133.582 147.587 1.00 45.28 ? 14 ASN B OD1 1 
ATOM   278  N ND2 . ASN B 1 14 ? 167.956 135.792 147.925 1.00 45.28 ? 14 ASN B ND2 1 
ATOM   279  N N   . PHE B 1 15 ? 162.684 134.225 147.242 1.00 44.94 ? 15 PHE B N   1 
ATOM   280  C CA  . PHE B 1 15 ? 161.327 134.509 146.802 1.00 44.94 ? 15 PHE B CA  1 
ATOM   281  C C   . PHE B 1 15 ? 160.919 135.881 147.311 1.00 44.94 ? 15 PHE B C   1 
ATOM   282  O O   . PHE B 1 15 ? 161.109 136.188 148.493 1.00 44.94 ? 15 PHE B O   1 
ATOM   283  C CB  . PHE B 1 15 ? 160.351 133.448 147.310 1.00 44.94 ? 15 PHE B CB  1 
ATOM   284  C CG  . PHE B 1 15 ? 160.554 132.096 146.698 1.00 44.94 ? 15 PHE B CG  1 
ATOM   285  C CD1 . PHE B 1 15 ? 161.525 131.243 147.187 1.00 44.94 ? 15 PHE B CD1 1 
ATOM   286  C CD2 . PHE B 1 15 ? 159.763 131.671 145.649 1.00 44.94 ? 15 PHE B CD2 1 
ATOM   287  C CE1 . PHE B 1 15 ? 161.714 129.996 146.630 1.00 44.94 ? 15 PHE B CE1 1 
ATOM   288  C CE2 . PHE B 1 15 ? 159.947 130.426 145.092 1.00 44.94 ? 15 PHE B CE2 1 
ATOM   289  C CZ  . PHE B 1 15 ? 160.923 129.587 145.584 1.00 44.94 ? 15 PHE B CZ  1 
ATOM   290  N N   . LEU B 1 16 ? 160.371 136.707 146.424 1.00 42.74 ? 16 LEU B N   1 
ATOM   291  C CA  . LEU B 1 16 ? 159.883 138.025 146.798 1.00 42.74 ? 16 LEU B CA  1 
ATOM   292  C C   . LEU B 1 16 ? 158.524 138.248 146.158 1.00 42.74 ? 16 LEU B C   1 
ATOM   293  O O   . LEU B 1 16 ? 158.367 138.062 144.950 1.00 42.74 ? 16 LEU B O   1 
ATOM   294  C CB  . LEU B 1 16 ? 160.853 139.130 146.364 1.00 42.74 ? 16 LEU B CB  1 
ATOM   295  C CG  . LEU B 1 16 ? 162.160 139.265 147.146 1.00 42.74 ? 16 LEU B CG  1 
ATOM   296  C CD1 . LEU B 1 16 ? 163.249 138.389 146.550 1.00 42.74 ? 16 LEU B CD1 1 
ATOM   297  C CD2 . LEU B 1 16 ? 162.602 140.718 147.180 1.00 42.74 ? 16 LEU B CD2 1 
ATOM   298  N N   . VAL B 1 17 ? 157.545 138.640 146.967 1.00 39.99 ? 17 VAL B N   1 
ATOM   299  C CA  . VAL B 1 17 ? 156.201 138.926 146.485 1.00 39.99 ? 17 VAL B CA  1 
ATOM   300  C C   . VAL B 1 17 ? 155.776 140.278 147.034 1.00 39.99 ? 17 VAL B C   1 
ATOM   301  O O   . VAL B 1 17 ? 155.851 140.511 148.246 1.00 39.99 ? 17 VAL B O   1 
ATOM   302  C CB  . VAL B 1 17 ? 155.196 137.838 146.895 1.00 39.99 ? 17 VAL B CB  1 
ATOM   303  C CG1 . VAL B 1 17 ? 153.787 138.255 146.521 1.00 39.99 ? 17 VAL B CG1 1 
ATOM   304  C CG2 . VAL B 1 17 ? 155.550 136.515 146.241 1.00 39.99 ? 17 VAL B CG2 1 
ATOM   305  N N   . HIS B 1 18 ? 155.339 141.168 146.151 1.00 41.68 ? 18 HIS B N   1 
ATOM   306  C CA  . HIS B 1 18 ? 154.717 142.433 146.531 1.00 41.68 ? 18 HIS B CA  1 
ATOM   307  C C   . HIS B 1 18 ? 153.336 142.432 145.889 1.00 41.68 ? 18 HIS B C   1 
ATOM   308  O O   . HIS B 1 18 ? 153.147 142.968 144.797 1.00 41.68 ? 18 HIS B O   1 
ATOM   309  C CB  . HIS B 1 18 ? 155.542 143.635 146.086 1.00 41.68 ? 18 HIS B CB  1 
ATOM   310  C CG  . HIS B 1 18 ? 156.822 143.804 146.839 1.00 41.68 ? 18 HIS B CG  1 
ATOM   311  N ND1 . HIS B 1 18 ? 157.847 142.885 146.782 1.00 41.68 ? 18 HIS B ND1 1 
ATOM   312  C CD2 . HIS B 1 18 ? 157.245 144.789 147.666 1.00 41.68 ? 18 HIS B CD2 1 
ATOM   313  C CE1 . HIS B 1 18 ? 158.847 143.296 147.541 1.00 41.68 ? 18 HIS B CE1 1 
ATOM   314  N NE2 . HIS B 1 18 ? 158.507 144.449 148.089 1.00 41.68 ? 18 HIS B NE2 1 
ATOM   315  N N   . SER B 1 19 ? 152.372 141.836 146.577 1.00 42.70 ? 19 SER B N   1 
ATOM   316  C CA  . SER B 1 19 ? 151.025 141.674 146.052 1.00 42.70 ? 19 SER B CA  1 
ATOM   317  C C   . SER B 1 19 ? 150.159 142.821 146.551 1.00 42.70 ? 19 SER B C   1 
ATOM   318  O O   . SER B 1 19 ? 150.123 143.101 147.753 1.00 42.70 ? 19 SER B O   1 
ATOM   319  C CB  . SER B 1 19 ? 150.440 140.328 146.473 1.00 42.70 ? 19 SER B CB  1 
ATOM   320  O OG  . SER B 1 19 ? 149.130 140.163 145.965 1.00 42.70 ? 19 SER B OG  1 
ATOM   321  N N   . SER B 1 20 ? 149.466 143.485 145.626 1.00 46.73 ? 20 SER B N   1 
ATOM   322  C CA  . SER B 1 20 ? 148.595 144.588 146.007 1.00 46.73 ? 20 SER B CA  1 
ATOM   323  C C   . SER B 1 20 ? 147.184 144.096 146.292 1.00 46.73 ? 20 SER B C   1 
ATOM   324  O O   . SER B 1 20 ? 146.609 144.410 147.340 1.00 46.73 ? 20 SER B O   1 
ATOM   325  C CB  . SER B 1 20 ? 148.580 145.651 144.907 1.00 46.73 ? 20 SER B CB  1 
ATOM   326  O OG  . SER B 1 20 ? 147.703 146.715 145.232 1.00 46.73 ? 20 SER B OG  1 
ATOM   327  N N   . ASN B 1 21 ? 146.604 143.331 145.370 1.00 47.90 ? 21 ASN B N   1 
ATOM   328  C CA  . ASN B 1 21 ? 145.249 142.817 145.562 1.00 47.90 ? 21 ASN B CA  1 
ATOM   329  C C   . ASN B 1 21 ? 145.166 141.467 144.847 1.00 47.90 ? 21 ASN B C   1 
ATOM   330  O O   . ASN B 1 21 ? 144.875 141.402 143.652 1.00 47.90 ? 21 ASN B O   1 
ATOM   331  C CB  . ASN B 1 21 ? 144.215 143.802 145.041 1.00 47.90 ? 21 ASN B CB  1 
ATOM   332  C CG  . ASN B 1 21 ? 142.873 143.643 145.706 1.00 47.90 ? 21 ASN B CG  1 
ATOM   333  O OD1 . ASN B 1 21 ? 142.583 142.606 146.299 1.00 47.90 ? 21 ASN B OD1 1 
ATOM   334  N ND2 . ASN B 1 21 ? 142.045 144.677 145.622 1.00 47.90 ? 21 ASN B ND2 1 
ATOM   335  N N   . ASN B 1 22 ? 145.403 140.399 145.599 1.00 48.43 ? 22 ASN B N   1 
ATOM   336  C CA  . ASN B 1 22 ? 145.454 139.053 145.051 1.00 48.43 ? 22 ASN B CA  1 
ATOM   337  C C   . ASN B 1 22 ? 144.110 138.362 145.208 1.00 48.43 ? 22 ASN B C   1 
ATOM   338  O O   . ASN B 1 22 ? 143.465 138.447 146.255 1.00 48.43 ? 22 ASN B O   1 
ATOM   339  C CB  . ASN B 1 22 ? 146.540 138.230 145.747 1.00 48.43 ? 22 ASN B CB  1 
ATOM   340  C CG  . ASN B 1 22 ? 146.695 136.846 145.152 1.00 48.43 ? 22 ASN B CG  1 
ATOM   341  O OD1 . ASN B 1 22 ? 146.090 136.518 144.133 1.00 48.43 ? 22 ASN B OD1 1 
ATOM   342  N ND2 . ASN B 1 22 ? 147.495 136.015 145.804 1.00 48.43 ? 22 ASN B ND2 1 
ATOM   343  N N   . PHE B 1 23 ? 143.691 137.668 144.148 1.00 47.15 ? 23 PHE B N   1 
ATOM   344  C CA  . PHE B 1 23 ? 142.490 136.853 144.179 1.00 47.15 ? 23 PHE B CA  1 
ATOM   345  C C   . PHE B 1 23 ? 142.739 135.425 143.717 1.00 47.15 ? 23 PHE B C   1 
ATOM   346  O O   . PHE B 1 23 ? 141.806 134.617 143.731 1.00 47.15 ? 23 PHE B O   1 
ATOM   347  C CB  . PHE B 1 23 ? 141.385 137.476 143.312 1.00 47.15 ? 23 PHE B CB  1 
ATOM   348  C CG  . PHE B 1 23 ? 140.871 138.784 143.832 1.00 47.15 ? 23 PHE B CG  1 
ATOM   349  C CD1 . PHE B 1 23 ? 141.459 139.973 143.450 1.00 47.15 ? 23 PHE B CD1 1 
ATOM   350  C CD2 . PHE B 1 23 ? 139.801 138.824 144.703 1.00 47.15 ? 23 PHE B CD2 1 
ATOM   351  C CE1 . PHE B 1 23 ? 140.991 141.177 143.926 1.00 47.15 ? 23 PHE B CE1 1 
ATOM   352  C CE2 . PHE B 1 23 ? 139.328 140.027 145.181 1.00 47.15 ? 23 PHE B CE2 1 
ATOM   353  C CZ  . PHE B 1 23 ? 139.923 141.203 144.791 1.00 47.15 ? 23 PHE B CZ  1 
ATOM   354  N N   . GLY B 1 24 ? 143.959 135.096 143.307 1.00 48.77 ? 24 GLY B N   1 
ATOM   355  C CA  . GLY B 1 24 ? 144.281 133.756 142.859 1.00 48.77 ? 24 GLY B CA  1 
ATOM   356  C C   . GLY B 1 24 ? 145.575 133.242 143.449 1.00 48.77 ? 24 GLY B C   1 
ATOM   357  O O   . GLY B 1 24 ? 145.944 133.611 144.567 1.00 48.77 ? 24 GLY B O   1 
ATOM   358  N N   . ALA B 1 25 ? 146.273 132.387 142.709 1.00 52.11 ? 25 ALA B N   1 
ATOM   359  C CA  . ALA B 1 25 ? 147.527 131.831 143.191 1.00 52.11 ? 25 ALA B CA  1 
ATOM   360  C C   . ALA B 1 25 ? 148.698 132.722 142.796 1.00 52.11 ? 25 ALA B C   1 
ATOM   361  O O   . ALA B 1 25 ? 148.626 133.492 141.836 1.00 52.11 ? 25 ALA B O   1 
ATOM   362  C CB  . ALA B 1 25 ? 147.731 130.423 142.633 1.00 52.11 ? 25 ALA B CB  1 
ATOM   363  N N   . ILE B 1 26 ? 149.787 132.616 143.555 1.00 52.02 ? 26 ILE B N   1 
ATOM   364  C CA  . ILE B 1 26 ? 151.003 133.356 143.240 1.00 52.02 ? 26 ILE B CA  1 
ATOM   365  C C   . ILE B 1 26 ? 152.157 132.381 143.057 1.00 52.02 ? 26 ILE B C   1 
ATOM   366  O O   . ILE B 1 26 ? 152.734 132.282 141.971 1.00 52.02 ? 26 ILE B O   1 
ATOM   367  C CB  . ILE B 1 26 ? 151.328 134.395 144.327 1.00 52.02 ? 26 ILE B CB  1 
ATOM   368  C CG1 . ILE B 1 26 ? 150.275 135.499 144.334 1.00 52.02 ? 26 ILE B CG1 1 
ATOM   369  C CG2 . ILE B 1 26 ? 152.701 134.988 144.098 1.00 52.02 ? 26 ILE B CG2 1 
ATOM   370  C CD1 . ILE B 1 26 ? 150.408 136.473 143.196 1.00 52.02 ? 26 ILE B CD1 1 
ATOM   371  N N   . LEU B 1 27 ? 152.492 131.651 144.115 1.00 55.33 ? 27 LEU B N   1 
ATOM   372  C CA  . LEU B 1 27 ? 153.557 130.656 144.108 1.00 55.33 ? 27 LEU B CA  1 
ATOM   373  C C   . LEU B 1 27 ? 153.050 129.356 144.714 1.00 55.33 ? 27 LEU B C   1 
ATOM   374  O O   . LEU B 1 27 ? 153.736 128.690 145.493 1.00 55.33 ? 27 LEU B O   1 
ATOM   375  C CB  . LEU B 1 27 ? 154.777 131.157 144.878 1.00 55.33 ? 27 LEU B CB  1 
ATOM   376  C CG  . LEU B 1 27 ? 155.981 131.797 144.182 1.00 55.33 ? 27 LEU B CG  1 
ATOM   377  C CD1 . LEU B 1 27 ? 156.718 130.786 143.331 1.00 55.33 ? 27 LEU B CD1 1 
ATOM   378  C CD2 . LEU B 1 27 ? 155.583 133.004 143.366 1.00 55.33 ? 27 LEU B CD2 1 
ATOM   379  N N   . SER B 1 28 ? 151.823 128.979 144.357 1.00 59.68 ? 28 SER B N   1 
ATOM   380  C CA  . SER B 1 28 ? 151.088 127.907 145.027 1.00 59.68 ? 28 SER B CA  1 
ATOM   381  C C   . SER B 1 28 ? 150.587 126.885 144.019 1.00 59.68 ? 28 SER B C   1 
ATOM   382  O O   . SER B 1 28 ? 149.458 126.994 143.514 1.00 59.68 ? 28 SER B O   1 
ATOM   383  C CB  . SER B 1 28 ? 149.930 128.489 145.830 1.00 59.68 ? 28 SER B CB  1 
ATOM   384  O OG  . SER B 1 28 ? 148.994 129.106 144.969 1.00 59.68 ? 28 SER B OG  1 
ATOM   385  N N   . PRO B 1 29 ? 151.386 125.866 143.701 1.00 62.30 ? 29 PRO B N   1 
ATOM   386  C CA  . PRO B 1 29 ? 150.936 124.836 142.759 1.00 62.30 ? 29 PRO B CA  1 
ATOM   387  C C   . PRO B 1 29 ? 149.752 124.049 143.301 1.00 62.30 ? 29 PRO B C   1 
ATOM   388  O O   . PRO B 1 29 ? 149.588 123.887 144.510 1.00 62.30 ? 29 PRO B O   1 
ATOM   389  C CB  . PRO B 1 29 ? 152.171 123.945 142.596 1.00 62.30 ? 29 PRO B CB  1 
ATOM   390  C CG  . PRO B 1 29 ? 152.966 124.178 143.831 1.00 62.30 ? 29 PRO B CG  1 
ATOM   391  C CD  . PRO B 1 29 ? 152.742 125.605 144.203 1.00 62.30 ? 29 PRO B CD  1 
ATOM   392  N N   . THR B 1 30 ? 148.921 123.554 142.386 1.00 65.05 ? 30 THR B N   1 
ATOM   393  C CA  . THR B 1 30 ? 147.697 122.852 142.747 1.00 65.05 ? 30 THR B CA  1 
ATOM   394  C C   . THR B 1 30 ? 147.639 121.504 142.041 1.00 65.05 ? 30 THR B C   1 
ATOM   395  O O   . THR B 1 30 ? 148.013 121.391 140.870 1.00 65.05 ? 30 THR B O   1 
ATOM   396  C CB  . THR B 1 30 ? 146.457 123.686 142.389 1.00 65.05 ? 30 THR B CB  1 
ATOM   397  O OG1 . THR B 1 30 ? 146.721 125.069 142.653 1.00 65.05 ? 30 THR B OG1 1 
ATOM   398  C CG2 . THR B 1 30 ? 145.265 123.256 143.225 1.00 65.05 ? 30 THR B CG2 1 
ATOM   399  N N   . ASN B 1 31 ? 147.163 120.486 142.765 1.00 66.60 ? 31 ASN B N   1 
ATOM   400  C CA  . ASN B 1 31 ? 147.032 119.118 142.251 1.00 66.60 ? 31 ASN B CA  1 
ATOM   401  C C   . ASN B 1 31 ? 148.344 118.613 141.654 1.00 66.60 ? 31 ASN B C   1 
ATOM   402  O O   . ASN B 1 31 ? 148.407 118.202 140.494 1.00 66.60 ? 31 ASN B O   1 
ATOM   403  C CB  . ASN B 1 31 ? 145.897 119.004 141.230 1.00 66.60 ? 31 ASN B CB  1 
ATOM   404  C CG  . ASN B 1 31 ? 144.782 119.989 141.481 1.00 66.60 ? 31 ASN B CG  1 
ATOM   405  O OD1 . ASN B 1 31 ? 144.798 121.105 140.967 1.00 66.60 ? 31 ASN B OD1 1 
ATOM   406  N ND2 . ASN B 1 31 ? 143.802 119.582 142.277 1.00 66.60 ? 31 ASN B ND2 1 
ATOM   407  N N   . VAL B 1 32 ? 149.402 118.629 142.459 1.00 65.77 ? 32 VAL B N   1 
ATOM   408  C CA  . VAL B 1 32 ? 150.721 118.232 141.996 1.00 65.77 ? 32 VAL B CA  1 
ATOM   409  C C   . VAL B 1 32 ? 151.151 116.985 142.755 1.00 65.77 ? 32 VAL B C   1 
ATOM   410  O O   . VAL B 1 32 ? 150.465 116.510 143.663 1.00 65.77 ? 32 VAL B O   1 
ATOM   411  C CB  . VAL B 1 32 ? 151.763 119.352 142.162 1.00 65.77 ? 32 VAL B CB  1 
ATOM   412  C CG1 . VAL B 1 32 ? 151.227 120.656 141.592 1.00 65.77 ? 32 VAL B CG1 1 
ATOM   413  C CG2 . VAL B 1 32 ? 152.183 119.495 143.606 1.00 65.77 ? 32 VAL B CG2 1 
ATOM   414  N N   . GLY B 1 33 ? 152.308 116.453 142.371 1.00 66.96 ? 33 GLY B N   1 
ATOM   415  C CA  . GLY B 1 33 ? 152.896 115.331 143.072 1.00 66.96 ? 33 GLY B CA  1 
ATOM   416  C C   . GLY B 1 33 ? 153.845 115.787 144.158 1.00 66.96 ? 33 GLY B C   1 
ATOM   417  O O   . GLY B 1 33 ? 153.426 116.432 145.122 1.00 66.96 ? 33 GLY B O   1 
ATOM   418  N N   . SER B 1 34 ? 155.124 115.459 144.014 1.00 66.15 ? 34 SER B N   1 
ATOM   419  C CA  . SER B 1 34 ? 156.145 115.883 144.971 1.00 66.15 ? 34 SER B CA  1 
ATOM   420  C C   . SER B 1 34 ? 156.549 117.317 144.655 1.00 66.15 ? 34 SER B C   1 
ATOM   421  O O   . SER B 1 34 ? 157.108 117.599 143.593 1.00 66.15 ? 34 SER B O   1 
ATOM   422  C CB  . SER B 1 34 ? 157.345 114.947 144.917 1.00 66.15 ? 34 SER B CB  1 
ATOM   423  O OG  . SER B 1 34 ? 158.353 115.355 145.826 1.00 66.15 ? 34 SER B OG  1 
ATOM   424  N N   . ASN B 1 35 ? 156.258 118.231 145.574 1.00 62.87 ? 35 ASN B N   1 
ATOM   425  C CA  . ASN B 1 35 ? 156.591 119.636 145.401 1.00 62.87 ? 35 ASN B CA  1 
ATOM   426  C C   . ASN B 1 35 ? 157.706 120.042 146.354 1.00 62.87 ? 35 ASN B C   1 
ATOM   427  O O   . ASN B 1 35 ? 157.732 119.619 147.513 1.00 62.87 ? 35 ASN B O   1 
ATOM   428  C CB  . ASN B 1 35 ? 155.362 120.514 145.634 1.00 62.87 ? 35 ASN B CB  1 
ATOM   429  C CG  . ASN B 1 35 ? 155.643 121.977 145.392 1.00 62.87 ? 35 ASN B CG  1 
ATOM   430  O OD1 . ASN B 1 35 ? 155.610 122.449 144.258 1.00 62.87 ? 35 ASN B OD1 1 
ATOM   431  N ND2 . ASN B 1 35 ? 155.926 122.708 146.461 1.00 62.87 ? 35 ASN B ND2 1 
ATOM   432  N N   . THR B 1 36 ? 158.631 120.857 145.856 1.00 61.48 ? 36 THR B N   1 
ATOM   433  C CA  . THR B 1 36 ? 159.751 121.326 146.660 1.00 61.48 ? 36 THR B CA  1 
ATOM   434  C C   . THR B 1 36 ? 160.077 122.761 146.280 1.00 61.48 ? 36 THR B C   1 
ATOM   435  O O   . THR B 1 36 ? 160.082 123.109 145.096 1.00 61.48 ? 36 THR B O   1 
ATOM   436  C CB  . THR B 1 36 ? 160.985 120.438 146.468 1.00 61.48 ? 36 THR B CB  1 
ATOM   437  O OG1 . THR B 1 36 ? 160.620 119.065 146.649 1.00 61.48 ? 36 THR B OG1 1 
ATOM   438  C CG2 . THR B 1 36 ? 162.065 120.804 147.473 1.00 61.48 ? 36 THR B CG2 1 
ATOM   439  N N   . TYR B 1 37 ? 160.347 123.587 147.287 1.00 57.79 ? 37 TYR B N   1 
ATOM   440  C CA  . TYR B 1 37 ? 160.761 124.968 147.062 1.00 57.79 ? 37 TYR B CA  1 
ATOM   441  C C   . TYR B 1 37 ? 162.269 125.128 147.203 1.00 57.79 ? 37 TYR B C   1 
ATOM   442  O O   . TYR B 1 37 ? 162.778 126.245 147.288 1.00 57.79 ? 37 TYR B O   1 
ATOM   443  C CB  . TYR B 1 37 ? 160.051 125.908 148.031 1.00 57.79 ? 37 TYR B CB  1 
ATOM   444  C CG  . TYR B 1 37 ? 158.604 126.168 147.693 1.00 57.79 ? 37 TYR B CG  1 
ATOM   445  C CD1 . TYR B 1 37 ? 158.250 127.187 146.828 1.00 57.79 ? 37 TYR B CD1 1 
ATOM   446  C CD2 . TYR B 1 37 ? 157.594 125.393 148.240 1.00 57.79 ? 37 TYR B CD2 1 
ATOM   447  C CE1 . TYR B 1 37 ? 156.932 127.429 146.517 1.00 57.79 ? 37 TYR B CE1 1 
ATOM   448  C CE2 . TYR B 1 37 ? 156.271 125.631 147.936 1.00 57.79 ? 37 TYR B CE2 1 
ATOM   449  C CZ  . TYR B 1 37 ? 155.948 126.649 147.073 1.00 57.79 ? 37 TYR B CZ  1 
ATOM   450  O OH  . TYR B 1 37 ? 154.632 126.891 146.763 1.00 57.79 ? 37 TYR B OH  1 
HETATM 451  N N   . NH2 B 1 38 ? 162.980 124.006 147.228 1.00 60.94 ? 38 NH2 B N   1 
ATOM   452  N N   . CYS C 1 2  ? 118.332 142.337 146.447 1.00 90.80 ? 2  CYS C N   1 
ATOM   453  C CA  . CYS C 1 2  ? 118.957 141.079 146.057 1.00 90.80 ? 2  CYS C CA  1 
ATOM   454  C C   . CYS C 1 2  ? 118.330 139.896 146.784 1.00 90.80 ? 2  CYS C C   1 
ATOM   455  O O   . CYS C 1 2  ? 118.051 139.970 147.979 1.00 90.80 ? 2  CYS C O   1 
ATOM   456  C CB  . CYS C 1 2  ? 120.462 141.120 146.329 1.00 90.80 ? 2  CYS C CB  1 
ATOM   457  S SG  . CYS C 1 2  ? 121.281 142.636 145.796 1.00 90.80 ? 2  CYS C SG  1 
ATOM   458  N N   . ASN C 1 3  ? 118.096 138.808 146.055 1.00 93.76 ? 3  ASN C N   1 
ATOM   459  C CA  . ASN C 1 3  ? 117.556 137.573 146.614 1.00 93.76 ? 3  ASN C CA  1 
ATOM   460  C C   . ASN C 1 3  ? 118.573 136.458 146.411 1.00 93.76 ? 3  ASN C C   1 
ATOM   461  O O   . ASN C 1 3  ? 118.816 136.034 145.276 1.00 93.76 ? 3  ASN C O   1 
ATOM   462  C CB  . ASN C 1 3  ? 116.216 137.219 145.969 1.00 93.76 ? 3  ASN C CB  1 
ATOM   463  C CG  . ASN C 1 3  ? 115.121 138.204 146.321 1.00 93.76 ? 3  ASN C CG  1 
ATOM   464  O OD1 . ASN C 1 3  ? 115.389 139.336 146.724 1.00 93.76 ? 3  ASN C OD1 1 
ATOM   465  N ND2 . ASN C 1 3  ? 113.873 137.776 146.173 1.00 93.76 ? 3  ASN C ND2 1 
ATOM   466  N N   . THR C 1 4  ? 119.156 135.982 147.514 1.00 90.60 ? 4  THR C N   1 
ATOM   467  C CA  . THR C 1 4  ? 120.136 134.892 147.505 1.00 90.60 ? 4  THR C CA  1 
ATOM   468  C C   . THR C 1 4  ? 121.268 135.168 146.519 1.00 90.60 ? 4  THR C C   1 
ATOM   469  O O   . THR C 1 4  ? 121.773 134.267 145.850 1.00 90.60 ? 4  THR C O   1 
ATOM   470  C CB  . THR C 1 4  ? 119.476 133.545 147.187 1.00 90.60 ? 4  THR C CB  1 
ATOM   471  O OG1 . THR C 1 4  ? 119.391 133.391 145.770 1.00 90.60 ? 4  THR C OG1 1 
ATOM   472  C CG2 . THR C 1 4  ? 118.072 133.462 147.768 1.00 90.60 ? 4  THR C CG2 1 
ATOM   473  N N   . ALA C 1 5  ? 121.679 136.433 146.433 1.00 84.35 ? 5  ALA C N   1 
ATOM   474  C CA  . ALA C 1 5  ? 122.586 136.878 145.384 1.00 84.35 ? 5  ALA C CA  1 
ATOM   475  C C   . ALA C 1 5  ? 123.674 137.761 145.975 1.00 84.35 ? 5  ALA C C   1 
ATOM   476  O O   . ALA C 1 5  ? 123.373 138.788 146.589 1.00 84.35 ? 5  ALA C O   1 
ATOM   477  C CB  . ALA C 1 5  ? 121.819 137.637 144.299 1.00 84.35 ? 5  ALA C CB  1 
ATOM   478  N N   . THR C 1 6  ? 124.931 137.381 145.766 1.00 78.58 ? 6  THR C N   1 
ATOM   479  C CA  . THR C 1 6  ? 126.056 138.218 146.167 1.00 78.58 ? 6  THR C CA  1 
ATOM   480  C C   . THR C 1 6  ? 126.150 139.401 145.213 1.00 78.58 ? 6  THR C C   1 
ATOM   481  O O   . THR C 1 6  ? 126.572 139.247 144.063 1.00 78.58 ? 6  THR C O   1 
ATOM   482  C CB  . THR C 1 6  ? 127.349 137.408 146.165 1.00 78.58 ? 6  THR C CB  1 
ATOM   483  O OG1 . THR C 1 6  ? 127.836 137.292 144.823 1.00 78.58 ? 6  THR C OG1 1 
ATOM   484  C CG2 . THR C 1 6  ? 127.103 136.017 146.720 1.00 78.58 ? 6  THR C CG2 1 
ATOM   485  N N   . CYS C 1 7  ? 125.772 140.587 145.682 1.00 81.23 ? 7  CYS C N   1 
ATOM   486  C CA  . CYS C 1 7  ? 125.545 141.742 144.818 1.00 81.23 ? 7  CYS C CA  1 
ATOM   487  C C   . CYS C 1 7  ? 126.376 142.934 145.273 1.00 81.23 ? 7  CYS C C   1 
ATOM   488  O O   . CYS C 1 7  ? 125.864 144.031 145.503 1.00 81.23 ? 7  CYS C O   1 
ATOM   489  C CB  . CYS C 1 7  ? 124.062 142.099 144.750 1.00 81.23 ? 7  CYS C CB  1 
ATOM   490  S SG  . CYS C 1 7  ? 123.224 142.343 146.308 1.00 81.23 ? 7  CYS C SG  1 
ATOM   491  N N   . ALA C 1 8  ? 127.682 142.715 145.432 1.00 73.82 ? 8  ALA C N   1 
ATOM   492  C CA  . ALA C 1 8  ? 128.594 143.781 145.827 1.00 73.82 ? 8  ALA C CA  1 
ATOM   493  C C   . ALA C 1 8  ? 128.496 144.978 144.885 1.00 73.82 ? 8  ALA C C   1 
ATOM   494  O O   . ALA C 1 8  ? 128.490 144.823 143.664 1.00 73.82 ? 8  ALA C O   1 
ATOM   495  C CB  . ALA C 1 8  ? 130.028 143.255 145.853 1.00 73.82 ? 8  ALA C CB  1 
ATOM   496  N N   . THR C 1 9  ? 128.420 146.176 145.461 1.00 70.04 ? 9  THR C N   1 
ATOM   497  C CA  . THR C 1 9  ? 128.282 147.408 144.700 1.00 70.04 ? 9  THR C CA  1 
ATOM   498  C C   . THR C 1 9  ? 129.161 148.493 145.303 1.00 70.04 ? 9  THR C C   1 
ATOM   499  O O   . THR C 1 9  ? 129.388 148.525 146.514 1.00 70.04 ? 9  THR C O   1 
ATOM   500  C CB  . THR C 1 9  ? 126.823 147.885 144.677 1.00 70.04 ? 9  THR C CB  1 
ATOM   501  O OG1 . THR C 1 9  ? 125.957 146.766 144.460 1.00 70.04 ? 9  THR C OG1 1 
ATOM   502  C CG2 . THR C 1 9  ? 126.606 148.903 143.568 1.00 70.04 ? 9  THR C CG2 1 
ATOM   503  N N   . GLN C 1 10 ? 129.670 149.381 144.448 1.00 63.39 ? 10 GLN C N   1 
ATOM   504  C CA  . GLN C 1 10 ? 130.303 150.607 144.911 1.00 63.39 ? 10 GLN C CA  1 
ATOM   505  C C   . GLN C 1 10 ? 129.858 151.767 144.035 1.00 63.39 ? 10 GLN C C   1 
ATOM   506  O O   . GLN C 1 10 ? 129.440 151.578 142.892 1.00 63.39 ? 10 GLN C O   1 
ATOM   507  C CB  . GLN C 1 10 ? 131.835 150.536 144.923 1.00 63.39 ? 10 GLN C CB  1 
ATOM   508  C CG  . GLN C 1 10 ? 132.473 149.594 143.932 1.00 63.39 ? 10 GLN C CG  1 
ATOM   509  C CD  . GLN C 1 10 ? 133.977 149.546 144.110 1.00 63.39 ? 10 GLN C CD  1 
ATOM   510  O OE1 . GLN C 1 10 ? 134.537 150.289 144.912 1.00 63.39 ? 10 GLN C OE1 1 
ATOM   511  N NE2 . GLN C 1 10 ? 134.639 148.683 143.357 1.00 63.39 ? 10 GLN C NE2 1 
ATOM   512  N N   . ARG C 1 11 ? 129.941 152.971 144.593 1.00 65.50 ? 11 ARG C N   1 
ATOM   513  C CA  . ARG C 1 11 ? 129.523 154.177 143.899 1.00 65.50 ? 11 ARG C CA  1 
ATOM   514  C C   . ARG C 1 11 ? 130.466 155.321 144.242 1.00 65.50 ? 11 ARG C C   1 
ATOM   515  O O   . ARG C 1 11 ? 130.833 155.505 145.405 1.00 65.50 ? 11 ARG C O   1 
ATOM   516  C CB  . ARG C 1 11 ? 128.087 154.566 144.262 1.00 65.50 ? 11 ARG C CB  1 
ATOM   517  C CG  . ARG C 1 11 ? 127.026 153.704 143.609 1.00 65.50 ? 11 ARG C CG  1 
ATOM   518  C CD  . ARG C 1 11 ? 125.638 154.284 143.833 1.00 65.50 ? 11 ARG C CD  1 
ATOM   519  N NE  . ARG C 1 11 ? 124.607 153.522 143.139 1.00 65.50 ? 11 ARG C NE  1 
ATOM   520  C CZ  . ARG C 1 11 ? 123.327 153.859 143.103 1.00 65.50 ? 11 ARG C CZ  1 
ATOM   521  N NH1 . ARG C 1 11 ? 122.881 154.948 143.708 1.00 65.50 ? 11 ARG C NH1 1 
ATOM   522  N NH2 . ARG C 1 11 ? 122.470 153.085 142.443 1.00 65.50 ? 11 ARG C NH2 1 
ATOM   523  N N   . LEU C 1 12 ? 130.853 156.081 143.221 1.00 64.37 ? 12 LEU C N   1 
ATOM   524  C CA  . LEU C 1 12 ? 131.618 157.309 143.387 1.00 64.37 ? 12 LEU C CA  1 
ATOM   525  C C   . LEU C 1 12 ? 130.904 158.403 142.610 1.00 64.37 ? 12 LEU C C   1 
ATOM   526  O O   . LEU C 1 12 ? 130.580 158.212 141.435 1.00 64.37 ? 12 LEU C O   1 
ATOM   527  C CB  . LEU C 1 12 ? 133.058 157.144 142.890 1.00 64.37 ? 12 LEU C CB  1 
ATOM   528  C CG  . LEU C 1 12 ? 133.993 156.241 143.700 1.00 64.37 ? 12 LEU C CG  1 
ATOM   529  C CD1 . LEU C 1 12 ? 133.849 154.790 143.289 1.00 64.37 ? 12 LEU C CD1 1 
ATOM   530  C CD2 . LEU C 1 12 ? 135.432 156.689 143.538 1.00 64.37 ? 12 LEU C CD2 1 
ATOM   531  N N   . ALA C 1 13 ? 130.648 159.538 143.255 1.00 70.00 ? 13 ALA C N   1 
ATOM   532  C CA  . ALA C 1 13 ? 129.839 160.557 142.601 1.00 70.00 ? 13 ALA C CA  1 
ATOM   533  C C   . ALA C 1 13 ? 130.157 161.935 143.162 1.00 70.00 ? 13 ALA C C   1 
ATOM   534  O O   . ALA C 1 13 ? 130.599 162.079 144.303 1.00 70.00 ? 13 ALA C O   1 
ATOM   535  C CB  . ALA C 1 13 ? 128.344 160.257 142.751 1.00 70.00 ? 13 ALA C CB  1 
ATOM   536  N N   . ASN C 1 14 ? 129.920 162.945 142.322 1.00 73.26 ? 14 ASN C N   1 
ATOM   537  C CA  . ASN C 1 14 ? 129.929 164.353 142.715 1.00 73.26 ? 14 ASN C CA  1 
ATOM   538  C C   . ASN C 1 14 ? 131.224 164.750 143.416 1.00 73.26 ? 14 ASN C C   1 
ATOM   539  O O   . ASN C 1 14 ? 131.222 165.453 144.428 1.00 73.26 ? 14 ASN C O   1 
ATOM   540  C CB  . ASN C 1 14 ? 128.716 164.677 143.587 1.00 73.26 ? 14 ASN C CB  1 
ATOM   541  C CG  . ASN C 1 14 ? 127.423 164.166 142.993 1.00 73.26 ? 14 ASN C CG  1 
ATOM   542  O OD1 . ASN C 1 14 ? 126.925 164.706 142.005 1.00 73.26 ? 14 ASN C OD1 1 
ATOM   543  N ND2 . ASN C 1 14 ? 126.866 163.124 143.595 1.00 73.26 ? 14 ASN C ND2 1 
ATOM   544  N N   . PHE C 1 15 ? 132.350 164.308 142.865 1.00 71.42 ? 15 PHE C N   1 
ATOM   545  C CA  . PHE C 1 15 ? 133.643 164.608 143.459 1.00 71.42 ? 15 PHE C CA  1 
ATOM   546  C C   . PHE C 1 15 ? 134.553 165.279 142.440 1.00 71.42 ? 15 PHE C C   1 
ATOM   547  O O   . PHE C 1 15 ? 134.204 165.448 141.271 1.00 71.42 ? 15 PHE C O   1 
ATOM   548  C CB  . PHE C 1 15 ? 134.306 163.350 144.028 1.00 71.42 ? 15 PHE C CB  1 
ATOM   549  C CG  . PHE C 1 15 ? 134.616 162.299 143.003 1.00 71.42 ? 15 PHE C CG  1 
ATOM   550  C CD1 . PHE C 1 15 ? 133.660 161.370 142.634 1.00 71.42 ? 15 PHE C CD1 1 
ATOM   551  C CD2 . PHE C 1 15 ? 135.874 162.222 142.434 1.00 71.42 ? 15 PHE C CD2 1 
ATOM   552  C CE1 . PHE C 1 15 ? 133.948 160.396 141.702 1.00 71.42 ? 15 PHE C CE1 1 
ATOM   553  C CE2 . PHE C 1 15 ? 136.168 161.251 141.499 1.00 71.42 ? 15 PHE C CE2 1 
ATOM   554  C CZ  . PHE C 1 15 ? 135.204 160.335 141.134 1.00 71.42 ? 15 PHE C CZ  1 
ATOM   555  N N   . LEU C 1 16 ? 135.730 165.686 142.913 1.00 72.35 ? 16 LEU C N   1 
ATOM   556  C CA  . LEU C 1 16 ? 136.742 166.313 142.072 1.00 72.35 ? 16 LEU C CA  1 
ATOM   557  C C   . LEU C 1 16 ? 138.111 165.876 142.559 1.00 72.35 ? 16 LEU C C   1 
ATOM   558  O O   . LEU C 1 16 ? 138.414 165.996 143.749 1.00 72.35 ? 16 LEU C O   1 
ATOM   559  C CB  . LEU C 1 16 ? 136.636 167.842 142.106 1.00 72.35 ? 16 LEU C CB  1 
ATOM   560  C CG  . LEU C 1 16 ? 135.427 168.491 141.430 1.00 72.35 ? 16 LEU C CG  1 
ATOM   561  C CD1 . LEU C 1 16 ? 134.317 168.746 142.435 1.00 72.35 ? 16 LEU C CD1 1 
ATOM   562  C CD2 . LEU C 1 16 ? 135.834 169.781 140.736 1.00 72.35 ? 16 LEU C CD2 1 
ATOM   563  N N   . VAL C 1 17 ? 138.933 165.375 141.645 1.00 69.22 ? 17 VAL C N   1 
ATOM   564  C CA  . VAL C 1 17 ? 140.278 164.912 141.964 1.00 69.22 ? 17 VAL C CA  1 
ATOM   565  C C   . VAL C 1 17 ? 141.241 165.734 141.120 1.00 69.22 ? 17 VAL C C   1 
ATOM   566  O O   . VAL C 1 17 ? 141.140 165.758 139.889 1.00 69.22 ? 17 VAL C O   1 
ATOM   567  C CB  . VAL C 1 17 ? 140.453 163.412 141.712 1.00 69.22 ? 17 VAL C CB  1 
ATOM   568  C CG1 . VAL C 1 17 ? 141.885 162.997 141.994 1.00 69.22 ? 17 VAL C CG1 1 
ATOM   569  C CG2 . VAL C 1 17 ? 139.492 162.620 142.573 1.00 69.22 ? 17 VAL C CG2 1 
ATOM   570  N N   . HIS C 1 18 ? 142.170 166.418 141.776 1.00 73.46 ? 18 HIS C N   1 
ATOM   571  C CA  . HIS C 1 18 ? 143.190 167.196 141.088 1.00 73.46 ? 18 HIS C CA  1 
ATOM   572  C C   . HIS C 1 18 ? 144.559 166.627 141.437 1.00 73.46 ? 18 HIS C C   1 
ATOM   573  O O   . HIS C 1 18 ? 144.890 166.473 142.618 1.00 73.46 ? 18 HIS C O   1 
ATOM   574  C CB  . HIS C 1 18 ? 143.096 168.670 141.478 1.00 73.46 ? 18 HIS C CB  1 
ATOM   575  C CG  . HIS C 1 18 ? 143.920 169.576 140.619 1.00 73.46 ? 18 HIS C CG  1 
ATOM   576  N ND1 . HIS C 1 18 ? 145.298 169.542 140.605 1.00 73.46 ? 18 HIS C ND1 1 
ATOM   577  C CD2 . HIS C 1 18 ? 143.560 170.546 139.746 1.00 73.46 ? 18 HIS C CD2 1 
ATOM   578  C CE1 . HIS C 1 18 ? 145.750 170.451 139.759 1.00 73.46 ? 18 HIS C CE1 1 
ATOM   579  N NE2 . HIS C 1 18 ? 144.716 171.073 139.226 1.00 73.46 ? 18 HIS C NE2 1 
ATOM   580  N N   . SER C 1 19 ? 145.352 166.317 140.417 1.00 68.99 ? 19 SER C N   1 
ATOM   581  C CA  . SER C 1 19 ? 146.674 165.742 140.608 1.00 68.99 ? 19 SER C CA  1 
ATOM   582  C C   . SER C 1 19 ? 147.696 166.521 139.796 1.00 68.99 ? 19 SER C C   1 
ATOM   583  O O   . SER C 1 19 ? 147.380 167.087 138.748 1.00 68.99 ? 19 SER C O   1 
ATOM   584  C CB  . SER C 1 19 ? 146.707 164.266 140.206 1.00 68.99 ? 19 SER C CB  1 
ATOM   585  O OG  . SER C 1 19 ? 148.006 163.727 140.381 1.00 68.99 ? 19 SER C OG  1 
ATOM   586  N N   . SER C 1 20 ? 148.929 166.545 140.296 1.00 71.47 ? 20 SER C N   1 
ATOM   587  C CA  . SER C 1 20 ? 150.024 167.249 139.643 1.00 71.47 ? 20 SER C CA  1 
ATOM   588  C C   . SER C 1 20 ? 151.114 166.305 139.169 1.00 71.47 ? 20 SER C C   1 
ATOM   589  O O   . SER C 1 20 ? 151.591 166.432 138.035 1.00 71.47 ? 20 SER C O   1 
ATOM   590  C CB  . SER C 1 20 ? 150.611 168.306 140.591 1.00 71.47 ? 20 SER C CB  1 
ATOM   591  O OG  . SER C 1 20 ? 149.624 169.251 140.964 1.00 71.47 ? 20 SER C OG  1 
ATOM   592  N N   . ASN C 1 21 ? 151.538 165.371 140.011 1.00 71.76 ? 21 ASN C N   1 
ATOM   593  C CA  . ASN C 1 21 ? 152.462 164.314 139.625 1.00 71.76 ? 21 ASN C CA  1 
ATOM   594  C C   . ASN C 1 21 ? 151.984 163.022 140.263 1.00 71.76 ? 21 ASN C C   1 
ATOM   595  O O   . ASN C 1 21 ? 151.544 163.028 141.415 1.00 71.76 ? 21 ASN C O   1 
ATOM   596  C CB  . ASN C 1 21 ? 153.892 164.632 140.062 1.00 71.76 ? 21 ASN C CB  1 
ATOM   597  C CG  . ASN C 1 21 ? 154.899 163.646 139.511 1.00 71.76 ? 21 ASN C CG  1 
ATOM   598  O OD1 . ASN C 1 21 ? 155.174 162.614 140.120 1.00 71.76 ? 21 ASN C OD1 1 
ATOM   599  N ND2 . ASN C 1 21 ? 155.468 163.969 138.356 1.00 71.76 ? 21 ASN C ND2 1 
ATOM   600  N N   . ASN C 1 22 ? 152.063 161.920 139.523 1.00 73.01 ? 22 ASN C N   1 
ATOM   601  C CA  . ASN C 1 22 ? 151.563 160.652 140.031 1.00 73.01 ? 22 ASN C CA  1 
ATOM   602  C C   . ASN C 1 22 ? 152.327 159.497 139.403 1.00 73.01 ? 22 ASN C C   1 
ATOM   603  O O   . ASN C 1 22 ? 152.621 159.504 138.207 1.00 73.01 ? 22 ASN C O   1 
ATOM   604  C CB  . ASN C 1 22 ? 150.066 160.493 139.760 1.00 73.01 ? 22 ASN C CB  1 
ATOM   605  C CG  . ASN C 1 22 ? 149.573 159.098 140.063 1.00 73.01 ? 22 ASN C CG  1 
ATOM   606  O OD1 . ASN C 1 22 ? 149.319 158.754 141.217 1.00 73.01 ? 22 ASN C OD1 1 
ATOM   607  N ND2 . ASN C 1 22 ? 149.441 158.279 139.028 1.00 73.01 ? 22 ASN C ND2 1 
ATOM   608  N N   . PHE C 1 23 ? 152.639 158.502 140.231 1.00 75.52 ? 23 PHE C N   1 
ATOM   609  C CA  . PHE C 1 23 ? 153.310 157.289 139.779 1.00 75.52 ? 23 PHE C CA  1 
ATOM   610  C C   . PHE C 1 23 ? 152.488 156.024 139.966 1.00 75.52 ? 23 PHE C C   1 
ATOM   611  O O   . PHE C 1 23 ? 152.939 154.955 139.539 1.00 75.52 ? 23 PHE C O   1 
ATOM   612  C CB  . PHE C 1 23 ? 154.653 157.109 140.503 1.00 75.52 ? 23 PHE C CB  1 
ATOM   613  C CG  . PHE C 1 23 ? 155.787 157.888 139.894 1.00 75.52 ? 23 PHE C CG  1 
ATOM   614  C CD1 . PHE C 1 23 ? 155.549 159.052 139.183 1.00 75.52 ? 23 PHE C CD1 1 
ATOM   615  C CD2 . PHE C 1 23 ? 157.094 157.458 140.043 1.00 75.52 ? 23 PHE C CD2 1 
ATOM   616  C CE1 . PHE C 1 23 ? 156.589 159.767 138.629 1.00 75.52 ? 23 PHE C CE1 1 
ATOM   617  C CE2 . PHE C 1 23 ? 158.138 158.170 139.490 1.00 75.52 ? 23 PHE C CE2 1 
ATOM   618  C CZ  . PHE C 1 23 ? 157.886 159.325 138.782 1.00 75.52 ? 23 PHE C CZ  1 
ATOM   619  N N   . GLY C 1 24 ? 151.318 156.099 140.598 1.00 76.04 ? 24 GLY C N   1 
ATOM   620  C CA  . GLY C 1 24 ? 150.475 154.935 140.787 1.00 76.04 ? 24 GLY C CA  1 
ATOM   621  C C   . GLY C 1 24 ? 149.023 155.214 140.454 1.00 76.04 ? 24 GLY C C   1 
ATOM   622  O O   . GLY C 1 24 ? 148.710 156.243 139.852 1.00 76.04 ? 24 GLY C O   1 
ATOM   623  N N   . ALA C 1 25 ? 148.129 154.307 140.833 1.00 73.14 ? 25 ALA C N   1 
ATOM   624  C CA  . ALA C 1 25 ? 146.707 154.517 140.601 1.00 73.14 ? 25 ALA C CA  1 
ATOM   625  C C   . ALA C 1 25 ? 146.196 155.673 141.448 1.00 73.14 ? 25 ALA C C   1 
ATOM   626  O O   . ALA C 1 25 ? 146.734 155.969 142.515 1.00 73.14 ? 25 ALA C O   1 
ATOM   627  C CB  . ALA C 1 25 ? 145.922 153.247 140.920 1.00 73.14 ? 25 ALA C CB  1 
ATOM   628  N N   . ILE C 1 26 ? 145.163 156.355 140.955 1.00 73.31 ? 26 ILE C N   1 
ATOM   629  C CA  . ILE C 1 26 ? 144.521 157.370 141.784 1.00 73.31 ? 26 ILE C CA  1 
ATOM   630  C C   . ILE C 1 26 ? 143.035 157.066 141.906 1.00 73.31 ? 26 ILE C C   1 
ATOM   631  O O   . ILE C 1 26 ? 142.404 157.432 142.902 1.00 73.31 ? 26 ILE C O   1 
ATOM   632  C CB  . ILE C 1 26 ? 144.751 158.797 141.253 1.00 73.31 ? 26 ILE C CB  1 
ATOM   633  C CG1 . ILE C 1 26 ? 143.777 159.136 140.130 1.00 73.31 ? 26 ILE C CG1 1 
ATOM   634  C CG2 . ILE C 1 26 ? 146.181 158.980 140.783 1.00 73.31 ? 26 ILE C CG2 1 
ATOM   635  C CD1 . ILE C 1 26 ? 143.757 160.604 139.772 1.00 73.31 ? 26 ILE C CD1 1 
ATOM   636  N N   . LEU C 1 27 ? 142.459 156.394 140.909 1.00 69.27 ? 27 LEU C N   1 
ATOM   637  C CA  . LEU C 1 27 ? 141.082 155.911 141.044 1.00 69.27 ? 27 LEU C CA  1 
ATOM   638  C C   . LEU C 1 27 ? 141.000 154.557 140.338 1.00 69.27 ? 27 LEU C C   1 
ATOM   639  O O   . LEU C 1 27 ? 140.688 154.482 139.150 1.00 69.27 ? 27 LEU C O   1 
ATOM   640  C CB  . LEU C 1 27 ? 140.071 156.895 140.474 1.00 69.27 ? 27 LEU C CB  1 
ATOM   641  C CG  . LEU C 1 27 ? 139.497 157.979 141.388 1.00 69.27 ? 27 LEU C CG  1 
ATOM   642  C CD1 . LEU C 1 27 ? 140.340 159.235 141.329 1.00 69.27 ? 27 LEU C CD1 1 
ATOM   643  C CD2 . LEU C 1 27 ? 138.061 158.282 141.020 1.00 69.27 ? 27 LEU C CD2 1 
ATOM   644  N N   . SER C 1 28 ? 141.256 153.493 141.089 1.00 69.58 ? 28 SER C N   1 
ATOM   645  C CA  . SER C 1 28 ? 141.133 152.127 140.580 1.00 69.58 ? 28 SER C CA  1 
ATOM   646  C C   . SER C 1 28 ? 140.435 151.262 141.618 1.00 69.58 ? 28 SER C C   1 
ATOM   647  O O   . SER C 1 28 ? 141.035 150.348 142.196 1.00 69.58 ? 28 SER C O   1 
ATOM   648  C CB  . SER C 1 28 ? 142.504 151.559 140.213 1.00 69.58 ? 28 SER C CB  1 
ATOM   649  O OG  . SER C 1 28 ? 143.203 152.454 139.368 1.00 69.58 ? 28 SER C OG  1 
ATOM   650  N N   . PRO C 1 29 ? 139.157 151.525 141.884 1.00 65.34 ? 29 PRO C N   1 
ATOM   651  C CA  . PRO C 1 29 ? 138.424 150.664 142.814 1.00 65.34 ? 29 PRO C CA  1 
ATOM   652  C C   . PRO C 1 29 ? 138.252 149.269 142.240 1.00 65.34 ? 29 PRO C C   1 
ATOM   653  O O   . PRO C 1 29 ? 138.151 149.085 141.026 1.00 65.34 ? 29 PRO C O   1 
ATOM   654  C CB  . PRO C 1 29 ? 137.078 151.380 142.974 1.00 65.34 ? 29 PRO C CB  1 
ATOM   655  C CG  . PRO C 1 29 ? 136.930 152.173 141.740 1.00 65.34 ? 29 PRO C CG  1 
ATOM   656  C CD  . PRO C 1 29 ? 138.305 152.588 141.332 1.00 65.34 ? 29 PRO C CD  1 
ATOM   657  N N   . THR C 1 30 ? 138.228 148.280 143.124 1.00 65.63 ? 30 THR C N   1 
ATOM   658  C CA  . THR C 1 30 ? 138.074 146.883 142.741 1.00 65.63 ? 30 THR C CA  1 
ATOM   659  C C   . THR C 1 30 ? 136.750 146.364 143.281 1.00 65.63 ? 30 THR C C   1 
ATOM   660  O O   . THR C 1 30 ? 136.477 146.483 144.478 1.00 65.63 ? 30 THR C O   1 
ATOM   661  C CB  . THR C 1 30 ? 139.229 146.031 143.267 1.00 65.63 ? 30 THR C CB  1 
ATOM   662  O OG1 . THR C 1 30 ? 140.469 146.536 142.754 1.00 65.63 ? 30 THR C OG1 1 
ATOM   663  C CG2 . THR C 1 30 ? 139.062 144.585 142.837 1.00 65.63 ? 30 THR C CG2 1 
ATOM   664  N N   . ASN C 1 31 ? 135.936 145.794 142.398 1.00 62.46 ? 31 ASN C N   1 
ATOM   665  C CA  . ASN C 1 31 ? 134.648 145.227 142.771 1.00 62.46 ? 31 ASN C CA  1 
ATOM   666  C C   . ASN C 1 31 ? 134.618 143.776 142.325 1.00 62.46 ? 31 ASN C C   1 
ATOM   667  O O   . ASN C 1 31 ? 134.774 143.489 141.135 1.00 62.46 ? 31 ASN C O   1 
ATOM   668  C CB  . ASN C 1 31 ? 133.495 146.007 142.136 1.00 62.46 ? 31 ASN C CB  1 
ATOM   669  C CG  . ASN C 1 31 ? 132.155 145.620 142.707 1.00 62.46 ? 31 ASN C CG  1 
ATOM   670  O OD1 . ASN C 1 31 ? 132.074 144.962 143.740 1.00 62.46 ? 31 ASN C OD1 1 
ATOM   671  N ND2 . ASN C 1 31 ? 131.090 146.037 142.041 1.00 62.46 ? 31 ASN C ND2 1 
ATOM   672  N N   . VAL C 1 32 ? 134.421 142.868 143.275 1.00 60.49 ? 32 VAL C N   1 
ATOM   673  C CA  . VAL C 1 32 ? 134.358 141.441 142.992 1.00 60.49 ? 32 VAL C CA  1 
ATOM   674  C C   . VAL C 1 32 ? 133.078 140.891 143.601 1.00 60.49 ? 32 VAL C C   1 
ATOM   675  O O   . VAL C 1 32 ? 132.867 140.999 144.813 1.00 60.49 ? 32 VAL C O   1 
ATOM   676  C CB  . VAL C 1 32 ? 135.587 140.694 143.542 1.00 60.49 ? 32 VAL C CB  1 
ATOM   677  C CG1 . VAL C 1 32 ? 135.371 139.193 143.464 1.00 60.49 ? 32 VAL C CG1 1 
ATOM   678  C CG2 . VAL C 1 32 ? 136.833 141.098 142.776 1.00 60.49 ? 32 VAL C CG2 1 
ATOM   679  N N   . GLY C 1 33 ? 132.223 140.311 142.760 1.00 61.00 ? 33 GLY C N   1 
ATOM   680  C CA  . GLY C 1 33 ? 130.988 139.735 143.263 1.00 61.00 ? 33 GLY C CA  1 
ATOM   681  C C   . GLY C 1 33 ? 131.224 138.533 144.156 1.00 61.00 ? 33 GLY C C   1 
ATOM   682  O O   . GLY C 1 33 ? 130.578 138.386 145.196 1.00 61.00 ? 33 GLY C O   1 
ATOM   683  N N   . SER C 1 34 ? 132.149 137.660 143.766 1.00 59.91 ? 34 SER C N   1 
ATOM   684  C CA  . SER C 1 34 ? 132.459 136.473 144.546 1.00 59.91 ? 34 SER C CA  1 
ATOM   685  C C   . SER C 1 34 ? 133.791 135.911 144.079 1.00 59.91 ? 34 SER C C   1 
ATOM   686  O O   . SER C 1 34 ? 134.154 136.032 142.908 1.00 59.91 ? 34 SER C O   1 
ATOM   687  C CB  . SER C 1 34 ? 131.363 135.411 144.419 1.00 59.91 ? 34 SER C CB  1 
ATOM   688  O OG  . SER C 1 34 ? 131.265 134.944 143.088 1.00 59.91 ? 34 SER C OG  1 
ATOM   689  N N   . ASN C 1 35 ? 134.515 135.296 145.011 1.00 64.80 ? 35 ASN C N   1 
ATOM   690  C CA  . ASN C 1 35 ? 135.803 134.662 144.734 1.00 64.80 ? 35 ASN C CA  1 
ATOM   691  C C   . ASN C 1 35 ? 135.765 133.250 145.307 1.00 64.80 ? 35 ASN C C   1 
ATOM   692  O O   . ASN C 1 35 ? 135.769 133.066 146.526 1.00 64.80 ? 35 ASN C O   1 
ATOM   693  C CB  . ASN C 1 35 ? 136.954 135.466 145.319 1.00 64.80 ? 35 ASN C CB  1 
ATOM   694  C CG  . ASN C 1 35 ? 138.298 135.006 144.807 1.00 64.80 ? 35 ASN C CG  1 
ATOM   695  O OD1 . ASN C 1 35 ? 138.396 134.017 144.080 1.00 64.80 ? 35 ASN C OD1 1 
ATOM   696  N ND2 . ASN C 1 35 ? 139.349 135.703 145.203 1.00 64.80 ? 35 ASN C ND2 1 
ATOM   697  N N   . THR C 1 36 ? 135.727 132.256 144.429 1.00 67.27 ? 36 THR C N   1 
ATOM   698  C CA  . THR C 1 36 ? 135.734 130.860 144.842 1.00 67.27 ? 36 THR C CA  1 
ATOM   699  C C   . THR C 1 36 ? 137.128 130.290 144.614 1.00 67.27 ? 36 THR C C   1 
ATOM   700  O O   . THR C 1 36 ? 137.679 130.394 143.515 1.00 67.27 ? 36 THR C O   1 
ATOM   701  C CB  . THR C 1 36 ? 134.682 130.062 144.077 1.00 67.27 ? 36 THR C CB  1 
ATOM   702  O OG1 . THR C 1 36 ? 133.376 130.531 144.434 1.00 67.27 ? 36 THR C OG1 1 
ATOM   703  C CG2 . THR C 1 36 ? 134.791 128.584 144.411 1.00 67.27 ? 36 THR C CG2 1 
ATOM   704  N N   . TYR C 1 37 ? 137.700 129.699 145.656 1.00 68.49 ? 37 TYR C N   1 
ATOM   705  C CA  . TYR C 1 37 ? 138.981 129.012 145.566 1.00 68.49 ? 37 TYR C CA  1 
ATOM   706  C C   . TYR C 1 37 ? 138.866 127.627 146.188 1.00 68.49 ? 37 TYR C C   1 
ATOM   707  O O   . TYR C 1 37 ? 139.664 127.249 147.044 1.00 68.49 ? 37 TYR C O   1 
ATOM   708  C CB  . TYR C 1 37 ? 140.079 129.823 146.254 1.00 68.49 ? 37 TYR C CB  1 
ATOM   709  C CG  . TYR C 1 37 ? 141.489 129.445 145.861 1.00 68.49 ? 37 TYR C CG  1 
ATOM   710  C CD1 . TYR C 1 37 ? 141.737 128.389 144.999 1.00 68.49 ? 37 TYR C CD1 1 
ATOM   711  C CD2 . TYR C 1 37 ? 142.576 130.140 146.367 1.00 68.49 ? 37 TYR C CD2 1 
ATOM   712  C CE1 . TYR C 1 37 ? 143.025 128.037 144.650 1.00 68.49 ? 37 TYR C CE1 1 
ATOM   713  C CE2 . TYR C 1 37 ? 143.864 129.797 146.023 1.00 68.49 ? 37 TYR C CE2 1 
ATOM   714  C CZ  . TYR C 1 37 ? 144.084 128.747 145.164 1.00 68.49 ? 37 TYR C CZ  1 
ATOM   715  O OH  . TYR C 1 37 ? 145.370 128.403 144.818 1.00 68.49 ? 37 TYR C OH  1 
HETATM 716  N N   . NH2 C 1 38 ? 137.863 126.872 145.753 1.00 69.60 ? 38 NH2 C N   1 
ATOM   717  N N   . ALA D 1 13 ? 167.928 130.597 141.996 1.00 44.34 ? 13 ALA D N   1 
ATOM   718  C CA  . ALA D 1 13 ? 166.761 130.981 141.212 1.00 44.34 ? 13 ALA D CA  1 
ATOM   719  C C   . ALA D 1 13 ? 165.934 132.028 141.944 1.00 44.34 ? 13 ALA D C   1 
ATOM   720  O O   . ALA D 1 13 ? 165.125 131.697 142.806 1.00 44.34 ? 13 ALA D O   1 
ATOM   721  C CB  . ALA D 1 13 ? 165.914 129.764 140.896 1.00 44.34 ? 13 ALA D CB  1 
ATOM   722  N N   . ASN D 1 14 ? 166.140 133.293 141.594 1.00 45.28 ? 14 ASN D N   1 
ATOM   723  C CA  . ASN D 1 14 ? 165.440 134.383 142.256 1.00 45.28 ? 14 ASN D CA  1 
ATOM   724  C C   . ASN D 1 14 ? 164.074 134.604 141.625 1.00 45.28 ? 14 ASN D C   1 
ATOM   725  O O   . ASN D 1 14 ? 163.925 134.575 140.400 1.00 45.28 ? 14 ASN D O   1 
ATOM   726  C CB  . ASN D 1 14 ? 166.263 135.667 142.182 1.00 45.28 ? 14 ASN D CB  1 
ATOM   727  C CG  . ASN D 1 14 ? 167.662 135.491 142.723 1.00 45.28 ? 14 ASN D CG  1 
ATOM   728  O OD1 . ASN D 1 14 ? 168.179 134.376 142.785 1.00 45.28 ? 14 ASN D OD1 1 
ATOM   729  N ND2 . ASN D 1 14 ? 168.287 136.590 143.121 1.00 45.28 ? 14 ASN D ND2 1 
ATOM   730  N N   . PHE D 1 15 ? 163.072 134.826 142.471 1.00 44.94 ? 15 PHE D N   1 
ATOM   731  C CA  . PHE D 1 15 ? 161.704 135.060 142.037 1.00 44.94 ? 15 PHE D CA  1 
ATOM   732  C C   . PHE D 1 15 ? 161.248 136.416 142.551 1.00 44.94 ? 15 PHE D C   1 
ATOM   733  O O   . PHE D 1 15 ? 161.433 136.730 143.730 1.00 44.94 ? 15 PHE D O   1 
ATOM   734  C CB  . PHE D 1 15 ? 160.772 133.963 142.554 1.00 44.94 ? 15 PHE D CB  1 
ATOM   735  C CG  . PHE D 1 15 ? 161.022 132.620 141.940 1.00 44.94 ? 15 PHE D CG  1 
ATOM   736  C CD1 . PHE D 1 15 ? 162.026 131.803 142.423 1.00 44.94 ? 15 PHE D CD1 1 
ATOM   737  C CD2 . PHE D 1 15 ? 160.240 132.166 140.898 1.00 44.94 ? 15 PHE D CD2 1 
ATOM   738  C CE1 . PHE D 1 15 ? 162.258 130.565 141.865 1.00 44.94 ? 15 PHE D CE1 1 
ATOM   739  C CE2 . PHE D 1 15 ? 160.466 130.926 140.337 1.00 44.94 ? 15 PHE D CE2 1 
ATOM   740  C CZ  . PHE D 1 15 ? 161.477 130.127 140.823 1.00 44.94 ? 15 PHE D CZ  1 
ATOM   741  N N   . LEU D 1 16 ? 160.665 137.220 141.666 1.00 42.74 ? 16 LEU D N   1 
ATOM   742  C CA  . LEU D 1 16 ? 160.128 138.520 142.043 1.00 42.74 ? 16 LEU D CA  1 
ATOM   743  C C   . LEU D 1 16 ? 158.758 138.691 141.414 1.00 42.74 ? 16 LEU D C   1 
ATOM   744  O O   . LEU D 1 16 ? 158.602 138.498 140.206 1.00 42.74 ? 16 LEU D O   1 
ATOM   745  C CB  . LEU D 1 16 ? 161.055 139.659 141.605 1.00 42.74 ? 16 LEU D CB  1 
ATOM   746  C CG  . LEU D 1 16 ? 162.361 139.843 142.377 1.00 42.74 ? 16 LEU D CG  1 
ATOM   747  C CD1 . LEU D 1 16 ? 163.476 139.008 141.775 1.00 42.74 ? 16 LEU D CD1 1 
ATOM   748  C CD2 . LEU D 1 16 ? 162.747 141.313 142.409 1.00 42.74 ? 16 LEU D CD2 1 
ATOM   749  N N   . VAL D 1 17 ? 157.771 139.046 142.228 1.00 39.99 ? 17 VAL D N   1 
ATOM   750  C CA  . VAL D 1 17 ? 156.414 139.282 141.754 1.00 39.99 ? 17 VAL D CA  1 
ATOM   751  C C   . VAL D 1 17 ? 155.943 140.618 142.305 1.00 39.99 ? 17 VAL D C   1 
ATOM   752  O O   . VAL D 1 17 ? 156.016 140.852 143.517 1.00 39.99 ? 17 VAL D O   1 
ATOM   753  C CB  . VAL D 1 17 ? 155.453 138.158 142.170 1.00 39.99 ? 17 VAL D CB  1 
ATOM   754  C CG1 . VAL D 1 17 ? 154.027 138.522 141.804 1.00 39.99 ? 17 VAL D CG1 1 
ATOM   755  C CG2 . VAL D 1 17 ? 155.853 136.849 141.514 1.00 39.99 ? 17 VAL D CG2 1 
ATOM   756  N N   . HIS D 1 18 ? 155.466 141.490 141.424 1.00 41.68 ? 18 HIS D N   1 
ATOM   757  C CA  . HIS D 1 18 ? 154.801 142.730 141.808 1.00 41.68 ? 18 HIS D CA  1 
ATOM   758  C C   . HIS D 1 18 ? 153.417 142.678 141.175 1.00 41.68 ? 18 HIS D C   1 
ATOM   759  O O   . HIS D 1 18 ? 153.201 143.207 140.083 1.00 41.68 ? 18 HIS D O   1 
ATOM   760  C CB  . HIS D 1 18 ? 155.576 143.962 141.358 1.00 41.68 ? 18 HIS D CB  1 
ATOM   761  C CG  . HIS D 1 18 ? 156.854 144.179 142.104 1.00 41.68 ? 18 HIS D CG  1 
ATOM   762  N ND1 . HIS D 1 18 ? 157.913 143.299 142.040 1.00 41.68 ? 18 HIS D ND1 1 
ATOM   763  C CD2 . HIS D 1 18 ? 157.245 145.180 142.929 1.00 41.68 ? 18 HIS D CD2 1 
ATOM   764  C CE1 . HIS D 1 18 ? 158.901 143.748 142.793 1.00 41.68 ? 18 HIS D CE1 1 
ATOM   765  N NE2 . HIS D 1 18 ? 158.521 144.886 143.343 1.00 41.68 ? 18 HIS D NE2 1 
ATOM   766  N N   . SER D 1 19 ? 152.479 142.046 141.868 1.00 42.70 ? 19 SER D N   1 
ATOM   767  C CA  . SER D 1 19 ? 151.135 141.833 141.352 1.00 42.70 ? 19 SER D CA  1 
ATOM   768  C C   . SER D 1 19 ? 150.230 142.947 141.856 1.00 42.70 ? 19 SER D C   1 
ATOM   769  O O   . SER D 1 19 ? 150.192 143.228 143.057 1.00 42.70 ? 19 SER D O   1 
ATOM   770  C CB  . SER D 1 19 ? 150.604 140.467 141.777 1.00 42.70 ? 19 SER D CB  1 
ATOM   771  O OG  . SER D 1 19 ? 149.298 140.254 141.277 1.00 42.70 ? 19 SER D OG  1 
ATOM   772  N N   . SER D 1 20 ? 149.509 143.585 140.936 1.00 46.73 ? 20 SER D N   1 
ATOM   773  C CA  . SER D 1 20 ? 148.599 144.654 141.321 1.00 46.73 ? 20 SER D CA  1 
ATOM   774  C C   . SER D 1 20 ? 147.208 144.110 141.617 1.00 46.73 ? 20 SER D C   1 
ATOM   775  O O   . SER D 1 20 ? 146.629 144.402 142.667 1.00 46.73 ? 20 SER D O   1 
ATOM   776  C CB  . SER D 1 20 ? 148.538 145.716 140.222 1.00 46.73 ? 20 SER D CB  1 
ATOM   777  O OG  . SER D 1 20 ? 147.621 146.747 140.553 1.00 46.73 ? 20 SER D OG  1 
ATOM   778  N N   . ASN D 1 21 ? 146.652 143.324 140.698 1.00 47.90 ? 21 ASN D N   1 
ATOM   779  C CA  . ASN D 1 21 ? 145.318 142.760 140.898 1.00 47.90 ? 21 ASN D CA  1 
ATOM   780  C C   . ASN D 1 21 ? 145.283 141.408 140.182 1.00 47.90 ? 21 ASN D C   1 
ATOM   781  O O   . ASN D 1 21 ? 144.987 141.332 138.989 1.00 47.90 ? 21 ASN D O   1 
ATOM   782  C CB  . ASN D 1 21 ? 144.245 143.706 140.382 1.00 47.90 ? 21 ASN D CB  1 
ATOM   783  C CG  . ASN D 1 21 ? 142.914 143.495 141.057 1.00 47.90 ? 21 ASN D CG  1 
ATOM   784  O OD1 . ASN D 1 21 ? 142.667 142.450 141.652 1.00 47.90 ? 21 ASN D OD1 1 
ATOM   785  N ND2 . ASN D 1 21 ? 142.048 144.497 140.976 1.00 47.90 ? 21 ASN D ND2 1 
ATOM   786  N N   . ASN D 1 22 ? 145.563 140.350 140.934 1.00 48.43 ? 22 ASN D N   1 
ATOM   787  C CA  . ASN D 1 22 ? 145.662 139.005 140.386 1.00 48.43 ? 22 ASN D CA  1 
ATOM   788  C C   . ASN D 1 22 ? 144.343 138.264 140.549 1.00 48.43 ? 22 ASN D C   1 
ATOM   789  O O   . ASN D 1 22 ? 143.703 138.325 141.600 1.00 48.43 ? 22 ASN D O   1 
ATOM   790  C CB  . ASN D 1 22 ? 146.781 138.224 141.075 1.00 48.43 ? 22 ASN D CB  1 
ATOM   791  C CG  . ASN D 1 22 ? 146.985 136.846 140.479 1.00 48.43 ? 22 ASN D CG  1 
ATOM   792  O OD1 . ASN D 1 22 ? 146.387 136.497 139.464 1.00 48.43 ? 22 ASN D OD1 1 
ATOM   793  N ND2 . ASN D 1 22 ? 147.820 136.046 141.125 1.00 48.43 ? 22 ASN D ND2 1 
ATOM   794  N N   . PHE D 1 23 ? 143.945 137.557 139.494 1.00 47.15 ? 23 PHE D N   1 
ATOM   795  C CA  . PHE D 1 23 ? 142.776 136.695 139.531 1.00 47.15 ? 23 PHE D CA  1 
ATOM   796  C C   . PHE D 1 23 ? 143.075 135.279 139.067 1.00 47.15 ? 23 PHE D C   1 
ATOM   797  O O   . PHE D 1 23 ? 142.172 134.436 139.087 1.00 47.15 ? 23 PHE D O   1 
ATOM   798  C CB  . PHE D 1 23 ? 141.643 137.278 138.673 1.00 47.15 ? 23 PHE D CB  1 
ATOM   799  C CG  . PHE D 1 23 ? 141.085 138.566 139.195 1.00 47.15 ? 23 PHE D CG  1 
ATOM   800  C CD1 . PHE D 1 23 ? 141.626 139.775 138.808 1.00 47.15 ? 23 PHE D CD1 1 
ATOM   801  C CD2 . PHE D 1 23 ? 140.018 138.565 140.072 1.00 47.15 ? 23 PHE D CD2 1 
ATOM   802  C CE1 . PHE D 1 23 ? 141.114 140.960 139.288 1.00 47.15 ? 23 PHE D CE1 1 
ATOM   803  C CE2 . PHE D 1 23 ? 139.503 139.749 140.553 1.00 47.15 ? 23 PHE D CE2 1 
ATOM   804  C CZ  . PHE D 1 23 ? 140.051 140.948 140.160 1.00 47.15 ? 23 PHE D CZ  1 
ATOM   805  N N   . GLY D 1 24 ? 144.304 134.995 138.650 1.00 48.77 ? 24 GLY D N   1 
ATOM   806  C CA  . GLY D 1 24 ? 144.674 133.669 138.201 1.00 48.77 ? 24 GLY D CA  1 
ATOM   807  C C   . GLY D 1 24 ? 145.989 133.203 138.783 1.00 48.77 ? 24 GLY D C   1 
ATOM   808  O O   . GLY D 1 24 ? 146.352 133.586 139.898 1.00 48.77 ? 24 GLY D O   1 
ATOM   809  N N   . ALA D 1 25 ? 146.714 132.376 138.040 1.00 52.11 ? 25 ALA D N   1 
ATOM   810  C CA  . ALA D 1 25 ? 147.991 131.865 138.512 1.00 52.11 ? 25 ALA D CA  1 
ATOM   811  C C   . ALA D 1 25 ? 149.126 132.800 138.110 1.00 52.11 ? 25 ALA D C   1 
ATOM   812  O O   . ALA D 1 25 ? 149.019 133.567 137.152 1.00 52.11 ? 25 ALA D O   1 
ATOM   813  C CB  . ALA D 1 25 ? 148.244 130.468 137.955 1.00 52.11 ? 25 ALA D CB  1 
ATOM   814  N N   . ILE D 1 26 ? 150.223 132.735 138.861 1.00 52.02 ? 26 ILE D N   1 
ATOM   815  C CA  . ILE D 1 26 ? 151.409 133.520 138.540 1.00 52.02 ? 26 ILE D CA  1 
ATOM   816  C C   . ILE D 1 26 ? 152.595 132.589 138.352 1.00 52.02 ? 26 ILE D C   1 
ATOM   817  O O   . ILE D 1 26 ? 153.171 132.512 137.261 1.00 52.02 ? 26 ILE D O   1 
ATOM   818  C CB  . ILE D 1 26 ? 151.701 134.570 139.625 1.00 52.02 ? 26 ILE D CB  1 
ATOM   819  C CG1 . ILE D 1 26 ? 150.607 135.635 139.639 1.00 52.02 ? 26 ILE D CG1 1 
ATOM   820  C CG2 . ILE D 1 26 ? 153.048 135.216 139.388 1.00 52.02 ? 26 ILE D CG2 1 
ATOM   821  C CD1 . ILE D 1 26 ? 150.696 136.613 138.500 1.00 52.02 ? 26 ILE D CD1 1 
ATOM   822  N N   . LEU D 1 27 ? 152.965 131.872 139.407 1.00 55.33 ? 27 LEU D N   1 
ATOM   823  C CA  . LEU D 1 27 ? 154.068 130.918 139.393 1.00 55.33 ? 27 LEU D CA  1 
ATOM   824  C C   . LEU D 1 27 ? 153.614 129.600 140.003 1.00 55.33 ? 27 LEU D C   1 
ATOM   825  O O   . LEU D 1 27 ? 154.328 128.960 140.777 1.00 55.33 ? 27 LEU D O   1 
ATOM   826  C CB  . LEU D 1 27 ? 155.272 131.464 140.155 1.00 55.33 ? 27 LEU D CB  1 
ATOM   827  C CG  . LEU D 1 27 ? 156.447 132.149 139.452 1.00 55.33 ? 27 LEU D CG  1 
ATOM   828  C CD1 . LEU D 1 27 ? 157.217 131.166 138.596 1.00 55.33 ? 27 LEU D CD1 1 
ATOM   829  C CD2 . LEU D 1 27 ? 155.998 133.341 138.637 1.00 55.33 ? 27 LEU D CD2 1 
ATOM   830  N N   . SER D 1 28 ? 152.398 129.178 139.653 1.00 59.68 ? 28 SER D N   1 
ATOM   831  C CA  . SER D 1 28 ? 151.708 128.080 140.328 1.00 59.68 ? 28 SER D CA  1 
ATOM   832  C C   . SER D 1 28 ? 151.239 127.037 139.321 1.00 59.68 ? 28 SER D C   1 
ATOM   833  O O   . SER D 1 28 ? 150.104 127.105 138.824 1.00 59.68 ? 28 SER D O   1 
ATOM   834  C CB  . SER D 1 28 ? 150.534 128.617 141.137 1.00 59.68 ? 28 SER D CB  1 
ATOM   835  O OG  . SER D 1 28 ? 149.571 129.197 140.281 1.00 59.68 ? 28 SER D OG  1 
ATOM   836  N N   . PRO D 1 29 ? 152.074 126.051 138.999 1.00 62.30 ? 29 PRO D N   1 
ATOM   837  C CA  . PRO D 1 29 ? 151.658 125.005 138.058 1.00 62.30 ? 29 PRO D CA  1 
ATOM   838  C C   . PRO D 1 29 ? 150.506 124.173 138.609 1.00 62.30 ? 29 PRO D C   1 
ATOM   839  O O   . PRO D 1 29 ? 150.356 124.005 139.819 1.00 62.30 ? 29 PRO D O   1 
ATOM   840  C CB  . PRO D 1 29 ? 152.923 124.158 137.890 1.00 62.30 ? 29 PRO D CB  1 
ATOM   841  C CG  . PRO D 1 29 ? 153.717 124.423 139.120 1.00 62.30 ? 29 PRO D CG  1 
ATOM   842  C CD  . PRO D 1 29 ? 153.443 125.840 139.493 1.00 62.30 ? 29 PRO D CD  1 
ATOM   843  N N   . THR D 1 30 ? 149.689 123.646 137.699 1.00 65.05 ? 30 THR D N   1 
ATOM   844  C CA  . THR D 1 30 ? 148.494 122.900 138.067 1.00 65.05 ? 30 THR D CA  1 
ATOM   845  C C   . THR D 1 30 ? 148.483 121.550 137.362 1.00 65.05 ? 30 THR D C   1 
ATOM   846  O O   . THR D 1 30 ? 148.854 121.451 136.189 1.00 65.05 ? 30 THR D O   1 
ATOM   847  C CB  . THR D 1 30 ? 147.222 123.687 137.717 1.00 65.05 ? 30 THR D CB  1 
ATOM   848  O OG1 . THR D 1 30 ? 147.434 125.078 137.980 1.00 65.05 ? 30 THR D OG1 1 
ATOM   849  C CG2 . THR D 1 30 ? 146.053 123.212 138.560 1.00 65.05 ? 30 THR D CG2 1 
ATOM   850  N N   . ASN D 1 31 ? 148.051 120.516 138.088 1.00 66.60 ? 31 ASN D N   1 
ATOM   851  C CA  . ASN D 1 31 ? 147.967 119.143 137.576 1.00 66.60 ? 31 ASN D CA  1 
ATOM   852  C C   . ASN D 1 31 ? 149.293 118.687 136.970 1.00 66.60 ? 31 ASN D C   1 
ATOM   853  O O   . ASN D 1 31 ? 149.365 118.280 135.810 1.00 66.60 ? 31 ASN D O   1 
ATOM   854  C CB  . ASN D 1 31 ? 146.832 118.987 136.562 1.00 66.60 ? 31 ASN D CB  1 
ATOM   855  C CG  . ASN D 1 31 ? 145.681 119.930 136.819 1.00 66.60 ? 31 ASN D CG  1 
ATOM   856  O OD1 . ASN D 1 31 ? 145.651 121.046 136.305 1.00 66.60 ? 31 ASN D OD1 1 
ATOM   857  N ND2 . ASN D 1 31 ? 144.722 119.486 137.622 1.00 66.60 ? 31 ASN D ND2 1 
ATOM   858  N N   . VAL D 1 32 ? 150.355 118.743 137.770 1.00 65.77 ? 32 VAL D N   1 
ATOM   859  C CA  . VAL D 1 32 ? 151.685 118.397 137.297 1.00 65.77 ? 32 VAL D CA  1 
ATOM   860  C C   . VAL D 1 32 ? 152.166 117.166 138.056 1.00 65.77 ? 32 VAL D C   1 
ATOM   861  O O   . VAL D 1 32 ? 151.503 116.665 138.965 1.00 65.77 ? 32 VAL D O   1 
ATOM   862  C CB  . VAL D 1 32 ? 152.685 119.555 137.457 1.00 65.77 ? 32 VAL D CB  1 
ATOM   863  C CG1 . VAL D 1 32 ? 152.099 120.837 136.890 1.00 65.77 ? 32 VAL D CG1 1 
ATOM   864  C CG2 . VAL D 1 32 ? 153.107 119.713 138.899 1.00 65.77 ? 32 VAL D CG2 1 
ATOM   865  N N   . GLY D 1 33 ? 153.340 116.678 137.663 1.00 66.96 ? 33 GLY D N   1 
ATOM   866  C CA  . GLY D 1 33 ? 153.974 115.579 138.360 1.00 66.96 ? 33 GLY D CA  1 
ATOM   867  C C   . GLY D 1 33 ? 154.911 116.070 139.441 1.00 66.96 ? 33 GLY D C   1 
ATOM   868  O O   . GLY D 1 33 ? 154.476 116.699 140.408 1.00 66.96 ? 33 GLY D O   1 
ATOM   869  N N   . SER D 1 34 ? 156.201 115.789 139.290 1.00 66.15 ? 34 SER D N   1 
ATOM   870  C CA  . SER D 1 34 ? 157.211 116.253 140.238 1.00 66.15 ? 34 SER D CA  1 
ATOM   871  C C   . SER D 1 34 ? 157.559 117.699 139.920 1.00 66.15 ? 34 SER D C   1 
ATOM   872  O O   . SER D 1 34 ? 158.101 118.003 138.855 1.00 66.15 ? 34 SER D O   1 
ATOM   873  C CB  . SER D 1 34 ? 158.444 115.361 140.180 1.00 66.15 ? 34 SER D CB  1 
ATOM   874  O OG  . SER D 1 34 ? 159.441 115.808 141.080 1.00 66.15 ? 34 SER D OG  1 
ATOM   875  N N   . ASN D 1 35 ? 157.240 118.604 140.841 1.00 62.87 ? 35 ASN D N   1 
ATOM   876  C CA  . ASN D 1 35 ? 157.519 120.020 140.665 1.00 62.87 ? 35 ASN D CA  1 
ATOM   877  C C   . ASN D 1 35 ? 158.624 120.466 141.613 1.00 62.87 ? 35 ASN D C   1 
ATOM   878  O O   . ASN D 1 35 ? 158.673 120.046 142.772 1.00 62.87 ? 35 ASN D O   1 
ATOM   879  C CB  . ASN D 1 35 ? 156.259 120.851 140.906 1.00 62.87 ? 35 ASN D CB  1 
ATOM   880  C CG  . ASN D 1 35 ? 156.484 122.324 140.664 1.00 62.87 ? 35 ASN D CG  1 
ATOM   881  O OD1 . ASN D 1 35 ? 156.425 122.794 139.530 1.00 62.87 ? 35 ASN D OD1 1 
ATOM   882  N ND2 . ASN D 1 35 ? 156.746 123.066 141.731 1.00 62.87 ? 35 ASN D ND2 1 
ATOM   883  N N   . THR D 1 36 ? 159.516 121.317 141.110 1.00 61.48 ? 36 THR D N   1 
ATOM   884  C CA  . THR D 1 36 ? 160.621 121.827 141.906 1.00 61.48 ? 36 THR D CA  1 
ATOM   885  C C   . THR D 1 36 ? 160.890 123.273 141.524 1.00 61.48 ? 36 THR D C   1 
ATOM   886  O O   . THR D 1 36 ? 160.876 123.622 140.341 1.00 61.48 ? 36 THR D O   1 
ATOM   887  C CB  . THR D 1 36 ? 161.886 120.986 141.707 1.00 61.48 ? 36 THR D CB  1 
ATOM   888  O OG1 . THR D 1 36 ? 161.574 119.599 141.891 1.00 61.48 ? 36 THR D OG1 1 
ATOM   889  C CG2 . THR D 1 36 ? 162.958 121.391 142.705 1.00 61.48 ? 36 THR D CG2 1 
ATOM   890  N N   . TYR D 1 37 ? 161.136 124.110 142.527 1.00 57.79 ? 37 TYR D N   1 
ATOM   891  C CA  . TYR D 1 37 ? 161.497 125.504 142.301 1.00 57.79 ? 37 TYR D CA  1 
ATOM   892  C C   . TYR D 1 37 ? 162.999 125.721 142.433 1.00 57.79 ? 37 TYR D C   1 
ATOM   893  O O   . TYR D 1 37 ? 163.464 126.856 142.516 1.00 57.79 ? 37 TYR D O   1 
ATOM   894  C CB  . TYR D 1 37 ? 160.757 126.418 143.275 1.00 57.79 ? 37 TYR D CB  1 
ATOM   895  C CG  . TYR D 1 37 ? 159.301 126.622 142.947 1.00 57.79 ? 37 TYR D CG  1 
ATOM   896  C CD1 . TYR D 1 37 ? 158.903 127.627 142.082 1.00 57.79 ? 37 TYR D CD1 1 
ATOM   897  C CD2 . TYR D 1 37 ? 158.324 125.812 143.500 1.00 57.79 ? 37 TYR D CD2 1 
ATOM   898  C CE1 . TYR D 1 37 ? 157.576 127.821 141.780 1.00 57.79 ? 37 TYR D CE1 1 
ATOM   899  C CE2 . TYR D 1 37 ? 156.991 125.999 143.203 1.00 57.79 ? 37 TYR D CE2 1 
ATOM   900  C CZ  . TYR D 1 37 ? 156.624 127.005 142.343 1.00 57.79 ? 37 TYR D CZ  1 
ATOM   901  O OH  . TYR D 1 37 ? 155.298 127.198 142.042 1.00 57.79 ? 37 TYR D OH  1 
HETATM 902  N N   . NH2 D 1 38 ? 163.751 124.625 142.455 1.00 60.94 ? 38 NH2 D N   1 
ATOM   903  N N   . CYS E 1 2  ? 118.580 141.145 141.772 1.00 90.80 ? 2  CYS E N   1 
ATOM   904  C CA  . CYS E 1 2  ? 119.258 139.916 141.377 1.00 90.80 ? 2  CYS E CA  1 
ATOM   905  C C   . CYS E 1 2  ? 118.688 138.706 142.107 1.00 90.80 ? 2  CYS E C   1 
ATOM   906  O O   . CYS E 1 2  ? 118.413 138.767 143.304 1.00 90.80 ? 2  CYS E O   1 
ATOM   907  C CB  . CYS E 1 2  ? 120.760 140.026 141.643 1.00 90.80 ? 2  CYS E CB  1 
ATOM   908  S SG  . CYS E 1 2  ? 121.507 141.578 141.106 1.00 90.80 ? 2  CYS E SG  1 
ATOM   909  N N   . ASN E 1 3  ? 118.500 137.609 141.377 1.00 93.76 ? 3  ASN E N   1 
ATOM   910  C CA  . ASN E 1 3  ? 118.019 136.351 141.937 1.00 93.76 ? 3  ASN E CA  1 
ATOM   911  C C   . ASN E 1 3  ? 119.085 135.283 141.727 1.00 93.76 ? 3  ASN E C   1 
ATOM   912  O O   . ASN E 1 3  ? 119.341 134.871 140.592 1.00 93.76 ? 3  ASN E O   1 
ATOM   913  C CB  . ASN E 1 3  ? 116.695 135.938 141.299 1.00 93.76 ? 3  ASN E CB  1 
ATOM   914  C CG  . ASN E 1 3  ? 115.557 136.873 141.657 1.00 93.76 ? 3  ASN E CG  1 
ATOM   915  O OD1 . ASN E 1 3  ? 115.777 138.013 142.060 1.00 93.76 ? 3  ASN E OD1 1 
ATOM   916  N ND2 . ASN E 1 3  ? 114.328 136.389 141.517 1.00 93.76 ? 3  ASN E ND2 1 
ATOM   917  N N   . THR E 1 4  ? 119.694 134.833 142.828 1.00 90.60 ? 4  THR E N   1 
ATOM   918  C CA  . THR E 1 4  ? 120.721 133.787 142.815 1.00 90.60 ? 4  THR E CA  1 
ATOM   919  C C   . THR E 1 4  ? 121.836 134.116 141.822 1.00 90.60 ? 4  THR E C   1 
ATOM   920  O O   . THR E 1 4  ? 122.378 133.237 141.150 1.00 90.60 ? 4  THR E O   1 
ATOM   921  C CB  . THR E 1 4  ? 120.122 132.414 142.498 1.00 90.60 ? 4  THR E CB  1 
ATOM   922  O OG1 . THR E 1 4  ? 120.037 132.257 141.081 1.00 90.60 ? 4  THR E OG1 1 
ATOM   923  C CG2 . THR E 1 4  ? 118.725 132.267 143.086 1.00 90.60 ? 4  THR E CG2 1 
ATOM   924  N N   . ALA E 1 5  ? 122.188 135.397 141.736 1.00 84.35 ? 5  ALA E N   1 
ATOM   925  C CA  . ALA E 1 5  ? 123.069 135.885 140.683 1.00 84.35 ? 5  ALA E CA  1 
ATOM   926  C C   . ALA E 1 5  ? 124.118 136.815 141.270 1.00 84.35 ? 5  ALA E C   1 
ATOM   927  O O   . ALA E 1 5  ? 123.774 137.826 141.885 1.00 84.35 ? 5  ALA E O   1 
ATOM   928  C CB  . ALA E 1 5  ? 122.264 136.610 139.602 1.00 84.35 ? 5  ALA E CB  1 
ATOM   929  N N   . THR E 1 6  ? 125.391 136.491 141.054 1.00 78.58 ? 6  THR E N   1 
ATOM   930  C CA  . THR E 1 6  ? 126.480 137.379 141.451 1.00 78.58 ? 6  THR E CA  1 
ATOM   931  C C   . THR E 1 6  ? 126.516 138.567 140.496 1.00 78.58 ? 6  THR E C   1 
ATOM   932  O O   . THR E 1 6  ? 126.937 138.432 139.344 1.00 78.58 ? 6  THR E O   1 
ATOM   933  C CB  . THR E 1 6  ? 127.808 136.628 141.440 1.00 78.58 ? 6  THR E CB  1 
ATOM   934  O OG1 . THR E 1 6  ? 128.292 136.536 140.096 1.00 78.58 ? 6  THR E OG1 1 
ATOM   935  C CG2 . THR E 1 6  ? 127.627 135.227 141.995 1.00 78.58 ? 6  THR E CG2 1 
ATOM   936  N N   . CYS E 1 7  ? 126.087 139.733 140.969 1.00 81.23 ? 7  CYS E N   1 
ATOM   937  C CA  . CYS E 1 7  ? 125.802 140.878 140.107 1.00 81.23 ? 7  CYS E CA  1 
ATOM   938  C C   . CYS E 1 7  ? 126.583 142.105 140.558 1.00 81.23 ? 7  CYS E C   1 
ATOM   939  O O   . CYS E 1 7  ? 126.022 143.178 140.793 1.00 81.23 ? 7  CYS E O   1 
ATOM   940  C CB  . CYS E 1 7  ? 124.306 141.166 140.046 1.00 81.23 ? 7  CYS E CB  1 
ATOM   941  S SG  . CYS E 1 7  ? 123.465 141.372 141.608 1.00 81.23 ? 7  CYS E SG  1 
ATOM   942  N N   . ALA E 1 8  ? 127.896 141.944 140.710 1.00 73.82 ? 8  ALA E N   1 
ATOM   943  C CA  . ALA E 1 8  ? 128.763 143.051 141.102 1.00 73.82 ? 8  ALA E CA  1 
ATOM   944  C C   . ALA E 1 8  ? 128.606 144.242 140.163 1.00 73.82 ? 8  ALA E C   1 
ATOM   945  O O   . ALA E 1 8  ? 128.600 144.088 138.940 1.00 73.82 ? 8  ALA E O   1 
ATOM   946  C CB  . ALA E 1 8  ? 130.217 142.589 141.122 1.00 73.82 ? 8  ALA E CB  1 
ATOM   947  N N   . THR E 1 9  ? 128.478 145.436 140.740 1.00 70.04 ? 9  THR E N   1 
ATOM   948  C CA  . THR E 1 9  ? 128.282 146.661 139.981 1.00 70.04 ? 9  THR E CA  1 
ATOM   949  C C   . THR E 1 9  ? 129.114 147.785 140.579 1.00 70.04 ? 9  THR E C   1 
ATOM   950  O O   . THR E 1 9  ? 129.345 147.825 141.789 1.00 70.04 ? 9  THR E O   1 
ATOM   951  C CB  . THR E 1 9  ? 126.803 147.072 139.965 1.00 70.04 ? 9  THR E CB  1 
ATOM   952  O OG1 . THR E 1 9  ? 125.986 145.914 139.753 1.00 70.04 ? 9  THR E OG1 1 
ATOM   953  C CG2 . THR E 1 9  ? 126.534 148.079 138.858 1.00 70.04 ? 9  THR E CG2 1 
ATOM   954  N N   . GLN E 1 10 ? 129.578 148.695 139.724 1.00 63.39 ? 10 GLN E N   1 
ATOM   955  C CA  . GLN E 1 10 ? 130.157 149.948 140.186 1.00 63.39 ? 10 GLN E CA  1 
ATOM   956  C C   . GLN E 1 10 ? 129.657 151.086 139.313 1.00 63.39 ? 10 GLN E C   1 
ATOM   957  O O   . GLN E 1 10 ? 129.241 150.880 138.172 1.00 63.39 ? 10 GLN E O   1 
ATOM   958  C CB  . GLN E 1 10 ? 131.691 149.945 140.188 1.00 63.39 ? 10 GLN E CB  1 
ATOM   959  C CG  . GLN E 1 10 ? 132.365 149.035 139.195 1.00 63.39 ? 10 GLN E CG  1 
ATOM   960  C CD  . GLN E 1 10 ? 133.871 149.054 139.366 1.00 63.39 ? 10 GLN E CD  1 
ATOM   961  O OE1 . GLN E 1 10 ? 134.402 149.821 140.166 1.00 63.39 ? 10 GLN E OE1 1 
ATOM   962  N NE2 . GLN E 1 10 ? 134.567 148.222 138.606 1.00 63.39 ? 10 GLN E NE2 1 
ATOM   963  N N   . ARG E 1 11 ? 129.686 152.294 139.872 1.00 65.50 ? 11 ARG E N   1 
ATOM   964  C CA  . ARG E 1 11 ? 129.212 153.481 139.179 1.00 65.50 ? 11 ARG E CA  1 
ATOM   965  C C   . ARG E 1 11 ? 130.104 154.664 139.520 1.00 65.50 ? 11 ARG E C   1 
ATOM   966  O O   . ARG E 1 11 ? 130.468 154.865 140.681 1.00 65.50 ? 11 ARG E O   1 
ATOM   967  C CB  . ARG E 1 11 ? 127.761 153.805 139.551 1.00 65.50 ? 11 ARG E CB  1 
ATOM   968  C CG  . ARG E 1 11 ? 126.736 152.896 138.903 1.00 65.50 ? 11 ARG E CG  1 
ATOM   969  C CD  . ARG E 1 11 ? 125.326 153.410 139.133 1.00 65.50 ? 11 ARG E CD  1 
ATOM   970  N NE  . ARG E 1 11 ? 124.328 152.604 138.445 1.00 65.50 ? 11 ARG E NE  1 
ATOM   971  C CZ  . ARG E 1 11 ? 123.031 152.884 138.414 1.00 65.50 ? 11 ARG E CZ  1 
ATOM   972  N NH1 . ARG E 1 11 ? 122.541 153.950 139.024 1.00 65.50 ? 11 ARG E NH1 1 
ATOM   973  N NH2 . ARG E 1 11 ? 122.207 152.072 137.757 1.00 65.50 ? 11 ARG E NH2 1 
ATOM   974  N N   . LEU E 1 12 ? 130.453 155.441 138.499 1.00 64.37 ? 12 LEU E N   1 
ATOM   975  C CA  . LEU E 1 12 ? 131.162 156.704 138.661 1.00 64.37 ? 12 LEU E CA  1 
ATOM   976  C C   . LEU E 1 12 ? 130.395 157.764 137.888 1.00 64.37 ? 12 LEU E C   1 
ATOM   977  O O   . LEU E 1 12 ? 130.075 157.561 136.714 1.00 64.37 ? 12 LEU E O   1 
ATOM   978  C CB  . LEU E 1 12 ? 132.606 156.603 138.157 1.00 64.37 ? 12 LEU E CB  1 
ATOM   979  C CG  . LEU E 1 12 ? 133.583 155.743 138.960 1.00 64.37 ? 12 LEU E CG  1 
ATOM   980  C CD1 . LEU E 1 12 ? 133.503 154.287 138.550 1.00 64.37 ? 12 LEU E CD1 1 
ATOM   981  C CD2 . LEU E 1 12 ? 135.000 156.255 138.792 1.00 64.37 ? 12 LEU E CD2 1 
ATOM   982  N N   . ALA E 1 13 ? 130.091 158.886 138.538 1.00 70.00 ? 13 ALA E N   1 
ATOM   983  C CA  . ALA E 1 13 ? 129.234 159.867 137.888 1.00 70.00 ? 13 ALA E CA  1 
ATOM   984  C C   . ALA E 1 13 ? 129.491 161.258 138.448 1.00 70.00 ? 13 ALA E C   1 
ATOM   985  O O   . ALA E 1 13 ? 129.932 161.423 139.588 1.00 70.00 ? 13 ALA E O   1 
ATOM   986  C CB  . ALA E 1 13 ? 127.756 159.501 138.045 1.00 70.00 ? 13 ALA E CB  1 
ATOM   987  N N   . ASN E 1 14 ? 129.207 162.257 137.612 1.00 73.26 ? 14 ASN E N   1 
ATOM   988  C CA  . ASN E 1 14 ? 129.154 163.665 138.005 1.00 73.26 ? 14 ASN E CA  1 
ATOM   989  C C   . ASN E 1 14 ? 130.434 164.119 138.700 1.00 73.26 ? 14 ASN E C   1 
ATOM   990  O O   . ASN E 1 14 ? 130.403 164.821 139.713 1.00 73.26 ? 14 ASN E O   1 
ATOM   991  C CB  . ASN E 1 14 ? 127.932 163.932 138.884 1.00 73.26 ? 14 ASN E CB  1 
ATOM   992  C CG  . ASN E 1 14 ? 126.659 163.365 138.295 1.00 73.26 ? 14 ASN E CG  1 
ATOM   993  O OD1 . ASN E 1 14 ? 126.133 163.883 137.310 1.00 73.26 ? 14 ASN E OD1 1 
ATOM   994  N ND2 . ASN E 1 14 ? 126.153 162.297 138.898 1.00 73.26 ? 14 ASN E ND2 1 
ATOM   995  N N   . PHE E 1 15 ? 131.575 163.729 138.143 1.00 71.42 ? 15 PHE E N   1 
ATOM   996  C CA  . PHE E 1 15 ? 132.855 164.086 138.731 1.00 71.42 ? 15 PHE E CA  1 
ATOM   997  C C   . PHE E 1 15 ? 133.730 164.796 137.708 1.00 71.42 ? 15 PHE E C   1 
ATOM   998  O O   . PHE E 1 15 ? 133.368 164.953 136.542 1.00 71.42 ? 15 PHE E O   1 
ATOM   999  C CB  . PHE E 1 15 ? 133.578 162.859 139.296 1.00 71.42 ? 15 PHE E CB  1 
ATOM   1000 C CG  . PHE E 1 15 ? 133.930 161.825 138.269 1.00 71.42 ? 15 PHE E CG  1 
ATOM   1001 C CD1 . PHE E 1 15 ? 133.014 160.855 137.902 1.00 71.42 ? 15 PHE E CD1 1 
ATOM   1002 C CD2 . PHE E 1 15 ? 135.188 161.804 137.691 1.00 71.42 ? 15 PHE E CD2 1 
ATOM   1003 C CE1 . PHE E 1 15 ? 133.342 159.893 136.967 1.00 71.42 ? 15 PHE E CE1 1 
ATOM   1004 C CE2 . PHE E 1 15 ? 135.520 160.848 136.755 1.00 71.42 ? 15 PHE E CE2 1 
ATOM   1005 C CZ  . PHE E 1 15 ? 134.597 159.889 136.394 1.00 71.42 ? 15 PHE E CZ  1 
ATOM   1006 N N   . LEU E 1 16 ? 134.888 165.257 138.174 1.00 72.35 ? 16 LEU E N   1 
ATOM   1007 C CA  . LEU E 1 16 ? 135.867 165.930 137.331 1.00 72.35 ? 16 LEU E CA  1 
ATOM   1008 C C   . LEU E 1 16 ? 137.258 165.555 137.810 1.00 72.35 ? 16 LEU E C   1 
ATOM   1009 O O   . LEU E 1 16 ? 137.562 165.688 138.999 1.00 72.35 ? 16 LEU E O   1 
ATOM   1010 C CB  . LEU E 1 16 ? 135.694 167.453 137.366 1.00 72.35 ? 16 LEU E CB  1 
ATOM   1011 C CG  . LEU E 1 16 ? 134.454 168.046 136.697 1.00 72.35 ? 16 LEU E CG  1 
ATOM   1012 C CD1 . LEU E 1 16 ? 133.337 168.250 137.708 1.00 72.35 ? 16 LEU E CD1 1 
ATOM   1013 C CD2 . LEU E 1 16 ? 134.798 169.354 136.002 1.00 72.35 ? 16 LEU E CD2 1 
ATOM   1014 N N   . VAL E 1 17 ? 138.097 165.092 136.892 1.00 69.22 ? 17 VAL E N   1 
ATOM   1015 C CA  . VAL E 1 17 ? 139.464 164.690 137.204 1.00 69.22 ? 17 VAL E CA  1 
ATOM   1016 C C   . VAL E 1 17 ? 140.384 165.555 136.356 1.00 69.22 ? 17 VAL E C   1 
ATOM   1017 O O   . VAL E 1 17 ? 140.275 165.576 135.124 1.00 69.22 ? 17 VAL E O   1 
ATOM   1018 C CB  . VAL E 1 17 ? 139.706 163.200 136.949 1.00 69.22 ? 17 VAL E CB  1 
ATOM   1019 C CG1 . VAL E 1 17 ? 141.154 162.848 137.224 1.00 69.22 ? 17 VAL E CG1 1 
ATOM   1020 C CG2 . VAL E 1 17 ? 138.784 162.364 137.815 1.00 69.22 ? 17 VAL E CG2 1 
ATOM   1021 N N   . HIS E 1 18 ? 141.284 166.281 137.008 1.00 73.46 ? 18 HIS E N   1 
ATOM   1022 C CA  . HIS E 1 18 ? 142.264 167.103 136.316 1.00 73.46 ? 18 HIS E CA  1 
ATOM   1023 C C   . HIS E 1 18 ? 143.660 166.596 136.658 1.00 73.46 ? 18 HIS E C   1 
ATOM   1024 O O   . HIS E 1 18 ? 144.002 166.457 137.836 1.00 73.46 ? 18 HIS E O   1 
ATOM   1025 C CB  . HIS E 1 18 ? 142.106 168.571 136.706 1.00 73.46 ? 18 HIS E CB  1 
ATOM   1026 C CG  . HIS E 1 18 ? 142.885 169.514 135.846 1.00 73.46 ? 18 HIS E CG  1 
ATOM   1027 N ND1 . HIS E 1 18 ? 144.262 169.542 135.826 1.00 73.46 ? 18 HIS E ND1 1 
ATOM   1028 C CD2 . HIS E 1 18 ? 142.477 170.469 134.976 1.00 73.46 ? 18 HIS E CD2 1 
ATOM   1029 C CE1 . HIS E 1 18 ? 144.669 170.471 134.978 1.00 73.46 ? 18 HIS E CE1 1 
ATOM   1030 N NE2 . HIS E 1 18 ? 143.605 171.047 134.450 1.00 73.46 ? 18 HIS E NE2 1 
ATOM   1031 N N   . SER E 1 19 ? 144.461 166.323 135.634 1.00 68.99 ? 19 SER E N   1 
ATOM   1032 C CA  . SER E 1 19 ? 145.807 165.807 135.817 1.00 68.99 ? 19 SER E CA  1 
ATOM   1033 C C   . SER E 1 19 ? 146.790 166.633 135.001 1.00 68.99 ? 19 SER E C   1 
ATOM   1034 O O   . SER E 1 19 ? 146.444 167.185 133.954 1.00 68.99 ? 19 SER E O   1 
ATOM   1035 C CB  . SER E 1 19 ? 145.907 164.336 135.414 1.00 68.99 ? 19 SER E CB  1 
ATOM   1036 O OG  . SER E 1 19 ? 147.228 163.856 135.580 1.00 68.99 ? 19 SER E OG  1 
ATOM   1037 N N   . SER E 1 20 ? 148.022 166.713 135.495 1.00 71.47 ? 20 SER E N   1 
ATOM   1038 C CA  . SER E 1 20 ? 149.081 167.466 134.835 1.00 71.47 ? 20 SER E CA  1 
ATOM   1039 C C   . SER E 1 20 ? 150.212 166.572 134.356 1.00 71.47 ? 20 SER E C   1 
ATOM   1040 O O   . SER E 1 20 ? 150.676 166.722 133.220 1.00 71.47 ? 20 SER E O   1 
ATOM   1041 C CB  . SER E 1 20 ? 149.625 168.546 135.782 1.00 71.47 ? 20 SER E CB  1 
ATOM   1042 O OG  . SER E 1 20 ? 148.599 169.447 136.163 1.00 71.47 ? 20 SER E OG  1 
ATOM   1043 N N   . ASN E 1 21 ? 150.681 165.657 135.196 1.00 71.76 ? 21 ASN E N   1 
ATOM   1044 C CA  . ASN E 1 21 ? 151.649 164.643 134.804 1.00 71.76 ? 21 ASN E CA  1 
ATOM   1045 C C   . ASN E 1 21 ? 151.233 163.330 135.443 1.00 71.76 ? 21 ASN E C   1 
ATOM   1046 O O   . ASN E 1 21 ? 150.798 163.317 136.598 1.00 71.76 ? 21 ASN E O   1 
ATOM   1047 C CB  . ASN E 1 21 ? 153.066 165.025 135.235 1.00 71.76 ? 21 ASN E CB  1 
ATOM   1048 C CG  . ASN E 1 21 ? 154.115 164.087 134.677 1.00 71.76 ? 21 ASN E CG  1 
ATOM   1049 O OD1 . ASN E 1 21 ? 154.439 163.066 135.284 1.00 71.76 ? 21 ASN E OD1 1 
ATOM   1050 N ND2 . ASN E 1 21 ? 154.662 164.436 133.520 1.00 71.76 ? 21 ASN E ND2 1 
ATOM   1051 N N   . ASN E 1 22 ? 151.359 162.234 134.701 1.00 73.01 ? 22 ASN E N   1 
ATOM   1052 C CA  . ASN E 1 22 ? 150.918 160.945 135.211 1.00 73.01 ? 22 ASN E CA  1 
ATOM   1053 C C   . ASN E 1 22 ? 151.731 159.826 134.579 1.00 73.01 ? 22 ASN E C   1 
ATOM   1054 O O   . ASN E 1 22 ? 152.017 159.845 133.380 1.00 73.01 ? 22 ASN E O   1 
ATOM   1055 C CB  . ASN E 1 22 ? 149.429 160.717 134.947 1.00 73.01 ? 22 ASN E CB  1 
ATOM   1056 C CG  . ASN E 1 22 ? 149.002 159.301 135.253 1.00 73.01 ? 22 ASN E CG  1 
ATOM   1057 O OD1 . ASN E 1 22 ? 148.767 158.948 136.406 1.00 73.01 ? 22 ASN E OD1 1 
ATOM   1058 N ND2 . ASN E 1 22 ? 148.902 158.479 134.218 1.00 73.01 ? 22 ASN E ND2 1 
ATOM   1059 N N   . PHE E 1 23 ? 152.091 158.844 135.404 1.00 75.52 ? 23 PHE E N   1 
ATOM   1060 C CA  . PHE E 1 23 ? 152.815 157.663 134.947 1.00 75.52 ? 23 PHE E CA  1 
ATOM   1061 C C   . PHE E 1 23 ? 152.051 156.363 135.137 1.00 75.52 ? 23 PHE E C   1 
ATOM   1062 O O   . PHE E 1 23 ? 152.549 155.316 134.705 1.00 75.52 ? 23 PHE E O   1 
ATOM   1063 C CB  . PHE E 1 23 ? 154.167 157.544 135.663 1.00 75.52 ? 23 PHE E CB  1 
ATOM   1064 C CG  . PHE E 1 23 ? 155.261 158.374 135.050 1.00 75.52 ? 23 PHE E CG  1 
ATOM   1065 C CD1 . PHE E 1 23 ? 154.970 159.526 134.342 1.00 75.52 ? 23 PHE E CD1 1 
ATOM   1066 C CD2 . PHE E 1 23 ? 156.588 158.003 135.192 1.00 75.52 ? 23 PHE E CD2 1 
ATOM   1067 C CE1 . PHE E 1 23 ? 155.973 160.288 133.783 1.00 75.52 ? 23 PHE E CE1 1 
ATOM   1068 C CE2 . PHE E 1 23 ? 157.596 158.761 134.635 1.00 75.52 ? 23 PHE E CE2 1 
ATOM   1069 C CZ  . PHE E 1 23 ? 157.288 159.905 133.931 1.00 75.52 ? 23 PHE E CZ  1 
ATOM   1070 N N   . GLY E 1 24 ? 150.883 156.384 135.774 1.00 76.04 ? 24 GLY E N   1 
ATOM   1071 C CA  . GLY E 1 24 ? 150.092 155.184 135.967 1.00 76.04 ? 24 GLY E CA  1 
ATOM   1072 C C   . GLY E 1 24 ? 148.629 155.397 135.641 1.00 76.04 ? 24 GLY E C   1 
ATOM   1073 O O   . GLY E 1 24 ? 148.267 156.412 135.042 1.00 76.04 ? 24 GLY E O   1 
ATOM   1074 N N   . ALA E 1 25 ? 147.778 154.450 136.024 1.00 73.14 ? 25 ALA E N   1 
ATOM   1075 C CA  . ALA E 1 25 ? 146.348 154.595 135.798 1.00 73.14 ? 25 ALA E CA  1 
ATOM   1076 C C   . ALA E 1 25 ? 145.788 155.728 136.649 1.00 73.14 ? 25 ALA E C   1 
ATOM   1077 O O   . ALA E 1 25 ? 146.317 156.046 137.715 1.00 73.14 ? 25 ALA E O   1 
ATOM   1078 C CB  . ALA E 1 25 ? 145.622 153.292 136.120 1.00 73.14 ? 25 ALA E CB  1 
ATOM   1079 N N   . ILE E 1 26 ? 144.722 156.363 136.162 1.00 73.31 ? 26 ILE E N   1 
ATOM   1080 C CA  . ILE E 1 26 ? 144.042 157.346 136.996 1.00 73.31 ? 26 ILE E CA  1 
ATOM   1081 C C   . ILE E 1 26 ? 142.571 156.975 137.125 1.00 73.31 ? 26 ILE E C   1 
ATOM   1082 O O   . ILE E 1 26 ? 141.928 157.313 138.123 1.00 73.31 ? 26 ILE E O   1 
ATOM   1083 C CB  . ILE E 1 26 ? 144.204 158.785 136.465 1.00 73.31 ? 26 ILE E CB  1 
ATOM   1084 C CG1 . ILE E 1 26 ? 143.209 159.079 135.346 1.00 73.31 ? 26 ILE E CG1 1 
ATOM   1085 C CG2 . ILE E 1 26 ? 145.622 159.030 135.987 1.00 73.31 ? 26 ILE E CG2 1 
ATOM   1086 C CD1 . ILE E 1 26 ? 143.121 160.544 134.990 1.00 73.31 ? 26 ILE E CD1 1 
ATOM   1087 N N   . LEU E 1 27 ? 142.021 156.280 136.130 1.00 69.27 ? 27 LEU E N   1 
ATOM   1088 C CA  . LEU E 1 27 ? 140.667 155.734 136.269 1.00 69.27 ? 27 LEU E CA  1 
ATOM   1089 C C   . LEU E 1 27 ? 140.643 154.379 135.562 1.00 69.27 ? 27 LEU E C   1 
ATOM   1090 O O   . LEU E 1 27 ? 140.328 154.291 134.378 1.00 69.27 ? 27 LEU E O   1 
ATOM   1091 C CB  . LEU E 1 27 ? 139.609 156.672 135.706 1.00 69.27 ? 27 LEU E CB  1 
ATOM   1092 C CG  . LEU E 1 27 ? 138.992 157.728 136.624 1.00 69.27 ? 27 LEU E CG  1 
ATOM   1093 C CD1 . LEU E 1 27 ? 139.778 159.023 136.562 1.00 69.27 ? 27 LEU E CD1 1 
ATOM   1094 C CD2 . LEU E 1 27 ? 137.541 157.967 136.264 1.00 69.27 ? 27 LEU E CD2 1 
ATOM   1095 N N   . SER E 1 28 ? 140.951 153.327 136.312 1.00 69.58 ? 28 SER E N   1 
ATOM   1096 C CA  . SER E 1 28 ? 140.885 151.958 135.802 1.00 69.58 ? 28 SER E CA  1 
ATOM   1097 C C   . SER E 1 28 ? 140.233 151.060 136.843 1.00 69.58 ? 28 SER E C   1 
ATOM   1098 O O   . SER E 1 28 ? 140.876 150.174 137.417 1.00 69.58 ? 28 SER E O   1 
ATOM   1099 C CB  . SER E 1 28 ? 142.280 151.452 135.428 1.00 69.58 ? 28 SER E CB  1 
ATOM   1100 O OG  . SER E 1 28 ? 142.933 152.379 134.580 1.00 69.58 ? 28 SER E OG  1 
ATOM   1101 N N   . PRO E 1 29 ? 138.947 151.265 137.116 1.00 65.34 ? 29 PRO E N   1 
ATOM   1102 C CA  . PRO E 1 29 ? 138.256 150.372 138.049 1.00 65.34 ? 29 PRO E CA  1 
ATOM   1103 C C   . PRO E 1 29 ? 138.145 148.972 137.472 1.00 65.34 ? 29 PRO E C   1 
ATOM   1104 O O   . PRO E 1 29 ? 138.046 148.784 136.258 1.00 65.34 ? 29 PRO E O   1 
ATOM   1105 C CB  . PRO E 1 29 ? 136.881 151.026 138.216 1.00 65.34 ? 29 PRO E CB  1 
ATOM   1106 C CG  . PRO E 1 29 ? 136.691 151.814 136.984 1.00 65.34 ? 29 PRO E CG  1 
ATOM   1107 C CD  . PRO E 1 29 ? 138.044 152.291 136.568 1.00 65.34 ? 29 PRO E CD  1 
ATOM   1108 N N   . THR E 1 30 ? 138.170 147.980 138.358 1.00 65.63 ? 30 THR E N   1 
ATOM   1109 C CA  . THR E 1 30 ? 138.077 146.581 137.973 1.00 65.63 ? 30 THR E CA  1 
ATOM   1110 C C   . THR E 1 30 ? 136.781 146.000 138.519 1.00 65.63 ? 30 THR E C   1 
ATOM   1111 O O   . THR E 1 30 ? 136.510 146.106 139.719 1.00 65.63 ? 30 THR E O   1 
ATOM   1112 C CB  . THR E 1 30 ? 139.273 145.780 138.493 1.00 65.63 ? 30 THR E CB  1 
ATOM   1113 O OG1 . THR E 1 30 ? 140.486 146.341 137.974 1.00 65.63 ? 30 THR E OG1 1 
ATOM   1114 C CG2 . THR E 1 30 ? 139.169 144.329 138.062 1.00 65.63 ? 30 THR E CG2 1 
ATOM   1115 N N   . ASN E 1 31 ? 135.989 145.397 137.640 1.00 62.46 ? 31 ASN E N   1 
ATOM   1116 C CA  . ASN E 1 31 ? 134.729 144.770 138.018 1.00 62.46 ? 31 ASN E CA  1 
ATOM   1117 C C   . ASN E 1 31 ? 134.762 143.320 137.572 1.00 62.46 ? 31 ASN E C   1 
ATOM   1118 O O   . ASN E 1 31 ? 134.925 143.041 136.380 1.00 62.46 ? 31 ASN E O   1 
ATOM   1119 C CB  . ASN E 1 31 ? 133.540 145.497 137.391 1.00 62.46 ? 31 ASN E CB  1 
ATOM   1120 C CG  . ASN E 1 31 ? 132.220 145.052 137.967 1.00 62.46 ? 31 ASN E CG  1 
ATOM   1121 O OD1 . ASN E 1 31 ? 132.174 144.389 139.001 1.00 62.46 ? 31 ASN E OD1 1 
ATOM   1122 N ND2 . ASN E 1 31 ? 131.135 145.420 137.307 1.00 62.46 ? 31 ASN E ND2 1 
ATOM   1123 N N   . VAL E 1 32 ? 134.611 142.402 138.521 1.00 60.49 ? 32 VAL E N   1 
ATOM   1124 C CA  . VAL E 1 32 ? 134.610 140.974 138.238 1.00 60.49 ? 32 VAL E CA  1 
ATOM   1125 C C   . VAL E 1 32 ? 133.361 140.368 138.852 1.00 60.49 ? 32 VAL E C   1 
ATOM   1126 O O   . VAL E 1 32 ? 133.153 140.465 140.065 1.00 60.49 ? 32 VAL E O   1 
ATOM   1127 C CB  . VAL E 1 32 ? 135.875 140.284 138.780 1.00 60.49 ? 32 VAL E CB  1 
ATOM   1128 C CG1 . VAL E 1 32 ? 135.728 138.775 138.702 1.00 60.49 ? 32 VAL E CG1 1 
ATOM   1129 C CG2 . VAL E 1 32 ? 137.098 140.743 138.010 1.00 60.49 ? 32 VAL E CG2 1 
ATOM   1130 N N   . GLY E 1 33 ? 132.530 139.749 138.015 1.00 61.00 ? 33 GLY E N   1 
ATOM   1131 C CA  . GLY E 1 33 ? 131.324 139.119 138.524 1.00 61.00 ? 33 GLY E CA  1 
ATOM   1132 C C   . GLY E 1 33 ? 131.618 137.928 139.414 1.00 61.00 ? 33 GLY E C   1 
ATOM   1133 O O   . GLY E 1 33 ? 130.985 137.751 140.458 1.00 61.00 ? 33 GLY E O   1 
ATOM   1134 N N   . SER E 1 34 ? 132.578 137.097 139.017 1.00 59.91 ? 34 SER E N   1 
ATOM   1135 C CA  . SER E 1 34 ? 132.946 135.925 139.796 1.00 59.91 ? 34 SER E CA  1 
ATOM   1136 C C   . SER E 1 34 ? 134.301 135.425 139.321 1.00 59.91 ? 34 SER E C   1 
ATOM   1137 O O   . SER E 1 34 ? 134.652 135.562 138.148 1.00 59.91 ? 34 SER E O   1 
ATOM   1138 C CB  . SER E 1 34 ? 131.898 134.816 139.673 1.00 59.91 ? 34 SER E CB  1 
ATOM   1139 O OG  . SER E 1 34 ? 131.817 134.344 138.342 1.00 59.91 ? 34 SER E OG  1 
ATOM   1140 N N   . ASN E 1 35 ? 135.056 134.843 140.249 1.00 64.80 ? 35 ASN E N   1 
ATOM   1141 C CA  . ASN E 1 35 ? 136.369 134.268 139.966 1.00 64.80 ? 35 ASN E CA  1 
ATOM   1142 C C   . ASN E 1 35 ? 136.397 132.854 140.538 1.00 64.80 ? 35 ASN E C   1 
ATOM   1143 O O   . ASN E 1 35 ? 136.417 132.670 141.756 1.00 64.80 ? 35 ASN E O   1 
ATOM   1144 C CB  . ASN E 1 35 ? 137.486 135.120 140.547 1.00 64.80 ? 35 ASN E CB  1 
ATOM   1145 C CG  . ASN E 1 35 ? 138.847 134.723 140.026 1.00 64.80 ? 35 ASN E CG  1 
ATOM   1146 O OD1 . ASN E 1 35 ? 138.985 133.740 139.298 1.00 64.80 ? 35 ASN E OD1 1 
ATOM   1147 N ND2 . ASN E 1 35 ? 139.868 135.467 140.419 1.00 64.80 ? 35 ASN E ND2 1 
ATOM   1148 N N   . THR E 1 36 ? 136.400 131.861 139.657 1.00 67.27 ? 36 THR E N   1 
ATOM   1149 C CA  . THR E 1 36 ? 136.472 130.464 140.070 1.00 67.27 ? 36 THR E CA  1 
ATOM   1150 C C   . THR E 1 36 ? 137.892 129.959 139.834 1.00 67.27 ? 36 THR E C   1 
ATOM   1151 O O   . THR E 1 36 ? 138.432 130.089 138.733 1.00 67.27 ? 36 THR E O   1 
ATOM   1152 C CB  . THR E 1 36 ? 135.454 129.620 139.309 1.00 67.27 ? 36 THR E CB  1 
ATOM   1153 O OG1 . THR E 1 36 ? 134.131 130.030 139.673 1.00 67.27 ? 36 THR E OG1 1 
ATOM   1154 C CG2 . THR E 1 36 ? 135.630 128.150 139.641 1.00 67.27 ? 36 THR E CG2 1 
ATOM   1155 N N   . TYR E 1 37 ? 138.492 129.394 140.873 1.00 68.49 ? 37 TYR E N   1 
ATOM   1156 C CA  . TYR E 1 37 ? 139.802 128.765 140.776 1.00 68.49 ? 37 TYR E CA  1 
ATOM   1157 C C   . TYR E 1 37 ? 139.753 127.376 141.398 1.00 68.49 ? 37 TYR E C   1 
ATOM   1158 O O   . TYR E 1 37 ? 140.573 127.035 142.250 1.00 68.49 ? 37 TYR E O   1 
ATOM   1159 C CB  . TYR E 1 37 ? 140.866 129.625 141.461 1.00 68.49 ? 37 TYR E CB  1 
ATOM   1160 C CG  . TYR E 1 37 ? 142.291 129.312 141.058 1.00 68.49 ? 37 TYR E CG  1 
ATOM   1161 C CD1 . TYR E 1 37 ? 142.581 128.266 140.195 1.00 68.49 ? 37 TYR E CD1 1 
ATOM   1162 C CD2 . TYR E 1 37 ? 143.347 130.052 141.561 1.00 68.49 ? 37 TYR E CD2 1 
ATOM   1163 C CE1 . TYR E 1 37 ? 143.882 127.975 139.840 1.00 68.49 ? 37 TYR E CE1 1 
ATOM   1164 C CE2 . TYR E 1 37 ? 144.648 129.770 141.210 1.00 68.49 ? 37 TYR E CE2 1 
ATOM   1165 C CZ  . TYR E 1 37 ? 144.911 128.730 140.349 1.00 68.49 ? 37 TYR E CZ  1 
ATOM   1166 O OH  . TYR E 1 37 ? 146.208 128.445 139.997 1.00 68.49 ? 37 TYR E OH  1 
HETATM 1167 N N   . NH2 E 1 38 ? 138.783 126.575 140.966 1.00 69.60 ? 38 NH2 E N   1 
ATOM   1168 N N   . ALA F 1 13 ? 168.451 131.360 137.262 1.00 44.34 ? 13 ALA F N   1 
ATOM   1169 C CA  . ALA F 1 13 ? 167.273 131.704 136.477 1.00 44.34 ? 13 ALA F CA  1 
ATOM   1170 C C   . ALA F 1 13 ? 166.409 132.722 137.210 1.00 44.34 ? 13 ALA F C   1 
ATOM   1171 O O   . ALA F 1 13 ? 165.611 132.363 138.071 1.00 44.34 ? 13 ALA F O   1 
ATOM   1172 C CB  . ALA F 1 13 ? 166.468 130.460 136.158 1.00 44.34 ? 13 ALA F CB  1 
ATOM   1173 N N   . ASN F 1 14 ? 166.572 133.992 136.861 1.00 45.28 ? 14 ASN F N   1 
ATOM   1174 C CA  . ASN F 1 14 ? 165.835 135.058 137.524 1.00 45.28 ? 14 ASN F CA  1 
ATOM   1175 C C   . ASN F 1 14 ? 164.463 135.233 136.892 1.00 45.28 ? 14 ASN F C   1 
ATOM   1176 O O   . ASN F 1 14 ? 164.317 135.200 135.668 1.00 45.28 ? 14 ASN F O   1 
ATOM   1177 C CB  . ASN F 1 14 ? 166.613 136.370 137.454 1.00 45.28 ? 14 ASN F CB  1 
ATOM   1178 C CG  . ASN F 1 14 ? 168.019 136.239 137.995 1.00 45.28 ? 14 ASN F CG  1 
ATOM   1179 O OD1 . ASN F 1 14 ? 168.572 135.142 138.055 1.00 45.28 ? 14 ASN F OD1 1 
ATOM   1180 N ND2 . ASN F 1 14 ? 168.605 137.359 138.396 1.00 45.28 ? 14 ASN F ND2 1 
ATOM   1181 N N   . PHE F 1 15 ? 163.455 135.422 137.736 1.00 44.94 ? 15 PHE F N   1 
ATOM   1182 C CA  . PHE F 1 15 ? 162.079 135.608 137.302 1.00 44.94 ? 15 PHE F CA  1 
ATOM   1183 C C   . PHE F 1 15 ? 161.576 136.947 137.817 1.00 44.94 ? 15 PHE F C   1 
ATOM   1184 O O   . PHE F 1 15 ? 161.749 137.265 138.997 1.00 44.94 ? 15 PHE F O   1 
ATOM   1185 C CB  . PHE F 1 15 ? 161.183 134.478 137.816 1.00 44.94 ? 15 PHE F CB  1 
ATOM   1186 C CG  . PHE F 1 15 ? 161.480 133.146 137.201 1.00 44.94 ? 15 PHE F CG  1 
ATOM   1187 C CD1 . PHE F 1 15 ? 162.512 132.363 137.683 1.00 44.94 ? 15 PHE F CD1 1 
ATOM   1188 C CD2 . PHE F 1 15 ? 160.716 132.667 136.156 1.00 44.94 ? 15 PHE F CD2 1 
ATOM   1189 C CE1 . PHE F 1 15 ? 162.786 131.134 137.125 1.00 44.94 ? 15 PHE F CE1 1 
ATOM   1190 C CE2 . PHE F 1 15 ? 160.985 131.437 135.595 1.00 44.94 ? 15 PHE F CE2 1 
ATOM   1191 C CZ  . PHE F 1 15 ? 162.021 130.671 136.081 1.00 44.94 ? 15 PHE F CZ  1 
ATOM   1192 N N   . LEU F 1 16 ? 160.966 137.732 136.933 1.00 42.74 ? 16 LEU F N   1 
ATOM   1193 C CA  . LEU F 1 16 ? 160.387 139.012 137.311 1.00 42.74 ? 16 LEU F CA  1 
ATOM   1194 C C   . LEU F 1 16 ? 159.012 139.137 136.680 1.00 42.74 ? 16 LEU F C   1 
ATOM   1195 O O   . LEU F 1 16 ? 158.863 138.940 135.471 1.00 42.74 ? 16 LEU F O   1 
ATOM   1196 C CB  . LEU F 1 16 ? 161.274 140.183 136.874 1.00 42.74 ? 16 LEU F CB  1 
ATOM   1197 C CG  . LEU F 1 16 ? 162.572 140.411 137.648 1.00 42.74 ? 16 LEU F CG  1 
ATOM   1198 C CD1 . LEU F 1 16 ? 163.717 139.614 137.048 1.00 42.74 ? 16 LEU F CD1 1 
ATOM   1199 C CD2 . LEU F 1 16 ? 162.908 141.892 137.682 1.00 42.74 ? 16 LEU F CD2 1 
ATOM   1200 N N   . VAL F 1 17 ? 158.012 139.458 137.493 1.00 39.99 ? 17 VAL F N   1 
ATOM   1201 C CA  . VAL F 1 17 ? 156.648 139.647 137.018 1.00 39.99 ? 17 VAL F CA  1 
ATOM   1202 C C   . VAL F 1 17 ? 156.131 140.966 137.571 1.00 39.99 ? 17 VAL F C   1 
ATOM   1203 O O   . VAL F 1 17 ? 156.196 141.201 138.783 1.00 39.99 ? 17 VAL F O   1 
ATOM   1204 C CB  . VAL F 1 17 ? 155.726 138.490 137.431 1.00 39.99 ? 17 VAL F CB  1 
ATOM   1205 C CG1 . VAL F 1 17 ? 154.288 138.806 137.064 1.00 39.99 ? 17 VAL F CG1 1 
ATOM   1206 C CG2 . VAL F 1 17 ? 156.170 137.196 136.775 1.00 39.99 ? 17 VAL F CG2 1 
ATOM   1207 N N   . HIS F 1 18 ? 155.626 141.822 136.691 1.00 41.68 ? 18 HIS F N   1 
ATOM   1208 C CA  . HIS F 1 18 ? 154.918 143.039 137.076 1.00 41.68 ? 18 HIS F CA  1 
ATOM   1209 C C   . HIS F 1 18 ? 153.537 142.941 136.440 1.00 41.68 ? 18 HIS F C   1 
ATOM   1210 O O   . HIS F 1 18 ? 153.304 143.463 135.349 1.00 41.68 ? 18 HIS F O   1 
ATOM   1211 C CB  . HIS F 1 18 ? 155.652 144.296 136.627 1.00 41.68 ? 18 HIS F CB  1 
ATOM   1212 C CG  . HIS F 1 18 ? 156.921 144.558 137.373 1.00 41.68 ? 18 HIS F CG  1 
ATOM   1213 N ND1 . HIS F 1 18 ? 158.009 143.714 137.311 1.00 41.68 ? 18 HIS F ND1 1 
ATOM   1214 C CD2 . HIS F 1 18 ? 157.277 145.568 138.201 1.00 41.68 ? 18 HIS F CD2 1 
ATOM   1215 C CE1 . HIS F 1 18 ? 158.981 144.195 138.067 1.00 41.68 ? 18 HIS F CE1 1 
ATOM   1216 N NE2 . HIS F 1 18 ? 158.561 145.319 138.619 1.00 41.68 ? 18 HIS F NE2 1 
ATOM   1217 N N   . SER F 1 19 ? 152.622 142.277 137.133 1.00 42.70 ? 19 SER F N   1 
ATOM   1218 C CA  . SER F 1 19 ? 151.287 142.019 136.613 1.00 42.70 ? 19 SER F CA  1 
ATOM   1219 C C   . SER F 1 19 ? 150.343 143.100 137.118 1.00 42.70 ? 19 SER F C   1 
ATOM   1220 O O   . SER F 1 19 ? 150.294 143.377 138.319 1.00 42.70 ? 19 SER F O   1 
ATOM   1221 C CB  . SER F 1 19 ? 150.802 140.634 137.036 1.00 42.70 ? 19 SER F CB  1 
ATOM   1222 O OG  . SER F 1 19 ? 149.505 140.377 136.535 1.00 42.70 ? 19 SER F OG  1 
ATOM   1223 N N   . SER F 1 20 ? 149.603 143.714 136.198 1.00 46.73 ? 20 SER F N   1 
ATOM   1224 C CA  . SER F 1 20 ? 148.655 144.753 136.584 1.00 46.73 ? 20 SER F CA  1 
ATOM   1225 C C   . SER F 1 20 ? 147.285 144.161 136.877 1.00 46.73 ? 20 SER F C   1 
ATOM   1226 O O   . SER F 1 20 ? 146.694 144.431 137.928 1.00 46.73 ? 20 SER F O   1 
ATOM   1227 C CB  . SER F 1 20 ? 148.560 145.813 135.485 1.00 46.73 ? 20 SER F CB  1 
ATOM   1228 O OG  . SER F 1 20 ? 147.609 146.811 135.817 1.00 46.73 ? 20 SER F OG  1 
ATOM   1229 N N   . ASN F 1 21 ? 146.756 143.358 135.956 1.00 47.90 ? 21 ASN F N   1 
ATOM   1230 C CA  . ASN F 1 21 ? 145.442 142.747 136.154 1.00 47.90 ? 21 ASN F CA  1 
ATOM   1231 C C   . ASN F 1 21 ? 145.453 141.396 135.438 1.00 47.90 ? 21 ASN F C   1 
ATOM   1232 O O   . ASN F 1 21 ? 145.161 141.311 134.243 1.00 47.90 ? 21 ASN F O   1 
ATOM   1233 C CB  . ASN F 1 21 ? 144.338 143.656 135.639 1.00 47.90 ? 21 ASN F CB  1 
ATOM   1234 C CG  . ASN F 1 21 ? 143.013 143.400 136.312 1.00 47.90 ? 21 ASN F CG  1 
ATOM   1235 O OD1 . ASN F 1 21 ? 142.801 142.346 136.904 1.00 47.90 ? 21 ASN F OD1 1 
ATOM   1236 N ND2 . ASN F 1 21 ? 142.113 144.371 136.232 1.00 47.90 ? 21 ASN F ND2 1 
ATOM   1237 N N   . ASN F 1 22 ? 145.768 140.346 136.186 1.00 48.43 ? 22 ASN F N   1 
ATOM   1238 C CA  . ASN F 1 22 ? 145.914 139.007 135.636 1.00 48.43 ? 22 ASN F CA  1 
ATOM   1239 C C   . ASN F 1 22 ? 144.620 138.222 135.800 1.00 48.43 ? 22 ASN F C   1 
ATOM   1240 O O   . ASN F 1 22 ? 143.979 138.259 136.848 1.00 48.43 ? 22 ASN F O   1 
ATOM   1241 C CB  . ASN F 1 22 ? 147.058 138.264 136.326 1.00 48.43 ? 22 ASN F CB  1 
ATOM   1242 C CG  . ASN F 1 22 ? 147.309 136.894 135.730 1.00 48.43 ? 22 ASN F CG  1 
ATOM   1243 O OD1 . ASN F 1 22 ? 146.725 136.526 134.713 1.00 48.43 ? 22 ASN F OD1 1 
ATOM   1244 N ND2 . ASN F 1 22 ? 148.169 136.122 136.375 1.00 48.43 ? 22 ASN F ND2 1 
ATOM   1245 N N   . PHE F 1 23 ? 144.249 137.502 134.742 1.00 47.15 ? 23 PHE F N   1 
ATOM   1246 C CA  . PHE F 1 23 ? 143.107 136.601 134.776 1.00 47.15 ? 23 PHE F CA  1 
ATOM   1247 C C   . PHE F 1 23 ? 143.456 135.197 134.311 1.00 47.15 ? 23 PHE F C   1 
ATOM   1248 O O   . PHE F 1 23 ? 142.583 134.323 134.329 1.00 47.15 ? 23 PHE F O   1 
ATOM   1249 C CB  . PHE F 1 23 ? 141.957 137.145 133.916 1.00 47.15 ? 23 PHE F CB  1 
ATOM   1250 C CG  . PHE F 1 23 ? 141.354 138.413 134.440 1.00 47.15 ? 23 PHE F CG  1 
ATOM   1251 C CD1 . PHE F 1 23 ? 141.855 139.642 134.056 1.00 47.15 ? 23 PHE F CD1 1 
ATOM   1252 C CD2 . PHE F 1 23 ? 140.289 138.376 135.315 1.00 47.15 ? 23 PHE F CD2 1 
ATOM   1253 C CE1 . PHE F 1 23 ? 141.303 140.808 134.537 1.00 47.15 ? 23 PHE F CE1 1 
ATOM   1254 C CE2 . PHE F 1 23 ? 139.733 139.541 135.799 1.00 47.15 ? 23 PHE F CE2 1 
ATOM   1255 C CZ  . PHE F 1 23 ? 140.240 140.758 135.408 1.00 47.15 ? 23 PHE F CZ  1 
ATOM   1256 N N   . GLY F 1 24 ? 144.695 134.955 133.895 1.00 48.77 ? 24 GLY F N   1 
ATOM   1257 C CA  . GLY F 1 24 ? 145.110 133.644 133.444 1.00 48.77 ? 24 GLY F CA  1 
ATOM   1258 C C   . GLY F 1 24 ? 146.442 133.221 134.027 1.00 48.77 ? 24 GLY F C   1 
ATOM   1259 O O   . GLY F 1 24 ? 146.787 133.614 135.143 1.00 48.77 ? 24 GLY F O   1 
ATOM   1260 N N   . ALA F 1 25 ? 147.194 132.419 133.284 1.00 52.11 ? 25 ALA F N   1 
ATOM   1261 C CA  . ALA F 1 25 ? 148.487 131.953 133.756 1.00 52.11 ? 25 ALA F CA  1 
ATOM   1262 C C   . ALA F 1 25 ? 149.589 132.926 133.357 1.00 52.11 ? 25 ALA F C   1 
ATOM   1263 O O   . ALA F 1 25 ? 149.456 133.690 132.400 1.00 52.11 ? 25 ALA F O   1 
ATOM   1264 C CB  . ALA F 1 25 ? 148.788 130.566 133.198 1.00 52.11 ? 25 ALA F CB  1 
ATOM   1265 N N   . ILE F 1 26 ? 150.687 132.899 134.110 1.00 52.02 ? 26 ILE F N   1 
ATOM   1266 C CA  . ILE F 1 26 ? 151.845 133.723 133.790 1.00 52.02 ? 26 ILE F CA  1 
ATOM   1267 C C   . ILE F 1 26 ? 153.064 132.833 133.602 1.00 52.02 ? 26 ILE F C   1 
ATOM   1268 O O   . ILE F 1 26 ? 153.642 132.776 132.512 1.00 52.02 ? 26 ILE F O   1 
ATOM   1269 C CB  . ILE F 1 26 ? 152.101 134.780 134.878 1.00 52.02 ? 26 ILE F CB  1 
ATOM   1270 C CG1 . ILE F 1 26 ? 150.972 135.809 134.892 1.00 52.02 ? 26 ILE F CG1 1 
ATOM   1271 C CG2 . ILE F 1 26 ? 153.427 135.473 134.642 1.00 52.02 ? 26 ILE F CG2 1 
ATOM   1272 C CD1 . ILE F 1 26 ? 151.028 136.790 133.754 1.00 52.02 ? 26 ILE F CD1 1 
ATOM   1273 N N   . LEU F 1 27 ? 153.455 132.128 134.657 1.00 55.33 ? 27 LEU F N   1 
ATOM   1274 C CA  . LEU F 1 27 ? 154.591 131.211 134.642 1.00 55.33 ? 27 LEU F CA  1 
ATOM   1275 C C   . LEU F 1 27 ? 154.182 129.878 135.250 1.00 55.33 ? 27 LEU F C   1 
ATOM   1276 O O   . LEU F 1 27 ? 154.916 129.263 136.025 1.00 55.33 ? 27 LEU F O   1 
ATOM   1277 C CB  . LEU F 1 27 ? 155.775 131.798 135.408 1.00 55.33 ? 27 LEU F CB  1 
ATOM   1278 C CG  . LEU F 1 27 ? 156.927 132.523 134.707 1.00 55.33 ? 27 LEU F CG  1 
ATOM   1279 C CD1 . LEU F 1 27 ? 157.730 131.567 133.850 1.00 55.33 ? 27 LEU F CD1 1 
ATOM   1280 C CD2 . LEU F 1 27 ? 156.439 133.699 133.894 1.00 55.33 ? 27 LEU F CD2 1 
ATOM   1281 N N   . SER F 1 28 ? 152.981 129.416 134.899 1.00 59.68 ? 28 SER F N   1 
ATOM   1282 C CA  . SER F 1 28 ? 152.329 128.293 135.570 1.00 59.68 ? 28 SER F CA  1 
ATOM   1283 C C   . SER F 1 28 ? 151.897 127.238 134.562 1.00 59.68 ? 28 SER F C   1 
ATOM   1284 O O   . SER F 1 28 ? 150.760 127.269 134.065 1.00 59.68 ? 28 SER F O   1 
ATOM   1285 C CB  . SER F 1 28 ? 151.137 128.790 136.380 1.00 59.68 ? 28 SER F CB  1 
ATOM   1286 O OG  . SER F 1 28 ? 150.155 129.340 135.525 1.00 59.68 ? 28 SER F OG  1 
ATOM   1287 N N   . PRO F 1 29 ? 152.764 126.279 134.241 1.00 62.30 ? 29 PRO F N   1 
ATOM   1288 C CA  . PRO F 1 29 ? 152.385 125.221 133.298 1.00 62.30 ? 29 PRO F CA  1 
ATOM   1289 C C   . PRO F 1 29 ? 151.263 124.352 133.846 1.00 62.30 ? 29 PRO F C   1 
ATOM   1290 O O   . PRO F 1 29 ? 151.116 124.176 135.057 1.00 62.30 ? 29 PRO F O   1 
ATOM   1291 C CB  . PRO F 1 29 ? 153.678 124.420 133.129 1.00 62.30 ? 29 PRO F CB  1 
ATOM   1292 C CG  . PRO F 1 29 ? 154.461 124.709 134.360 1.00 62.30 ? 29 PRO F CG  1 
ATOM   1293 C CD  . PRO F 1 29 ? 154.139 126.116 134.736 1.00 62.30 ? 29 PRO F CD  1 
ATOM   1294 N N   . THR F 1 30 ? 150.464 123.798 132.934 1.00 65.05 ? 30 THR F N   1 
ATOM   1295 C CA  . THR F 1 30 ? 149.294 123.010 133.300 1.00 65.05 ? 30 THR F CA  1 
ATOM   1296 C C   . THR F 1 30 ? 149.330 121.662 132.593 1.00 65.05 ? 30 THR F C   1 
ATOM   1297 O O   . THR F 1 30 ? 149.705 121.577 131.421 1.00 65.05 ? 30 THR F O   1 
ATOM   1298 C CB  . THR F 1 30 ? 147.998 123.754 132.949 1.00 65.05 ? 30 THR F CB  1 
ATOM   1299 O OG1 . THR F 1 30 ? 148.163 125.151 133.215 1.00 65.05 ? 30 THR F OG1 1 
ATOM   1300 C CG2 . THR F 1 30 ? 146.844 123.240 133.790 1.00 65.05 ? 30 THR F CG2 1 
ATOM   1301 N N   . ASN F 1 31 ? 148.932 120.613 133.317 1.00 66.60 ? 31 ASN F N   1 
ATOM   1302 C CA  . ASN F 1 31 ? 148.898 119.238 132.803 1.00 66.60 ? 31 ASN F CA  1 
ATOM   1303 C C   . ASN F 1 31 ? 150.239 118.828 132.199 1.00 66.60 ? 31 ASN F C   1 
ATOM   1304 O O   . ASN F 1 31 ? 150.324 118.425 131.037 1.00 66.60 ? 31 ASN F O   1 
ATOM   1305 C CB  . ASN F 1 31 ? 147.768 119.046 131.788 1.00 66.60 ? 31 ASN F CB  1 
ATOM   1306 C CG  . ASN F 1 31 ? 146.586 119.948 132.046 1.00 66.60 ? 31 ASN F CG  1 
ATOM   1307 O OD1 . ASN F 1 31 ? 146.518 121.063 131.533 1.00 66.60 ? 31 ASN F OD1 1 
ATOM   1308 N ND2 . ASN F 1 31 ? 145.641 119.470 132.846 1.00 66.60 ? 31 ASN F ND2 1 
ATOM   1309 N N   . VAL F 1 32 ? 151.297 118.921 132.998 1.00 65.77 ? 32 VAL F N   1 
ATOM   1310 C CA  . VAL F 1 32 ? 152.637 118.619 132.527 1.00 65.77 ? 32 VAL F CA  1 
ATOM   1311 C C   . VAL F 1 32 ? 153.160 117.405 133.285 1.00 65.77 ? 32 VAL F C   1 
ATOM   1312 O O   . VAL F 1 32 ? 152.514 116.881 134.193 1.00 65.77 ? 32 VAL F O   1 
ATOM   1313 C CB  . VAL F 1 32 ? 153.598 119.811 132.691 1.00 65.77 ? 32 VAL F CB  1 
ATOM   1314 C CG1 . VAL F 1 32 ? 152.967 121.074 132.125 1.00 65.77 ? 32 VAL F CG1 1 
ATOM   1315 C CG2 . VAL F 1 32 ? 154.014 119.981 134.132 1.00 65.77 ? 32 VAL F CG2 1 
ATOM   1316 N N   . GLY F 1 33 ? 154.350 116.958 132.892 1.00 66.96 ? 33 GLY F N   1 
ATOM   1317 C CA  . GLY F 1 33 ? 155.019 115.881 133.590 1.00 66.96 ? 33 GLY F CA  1 
ATOM   1318 C C   . GLY F 1 33 ? 155.939 116.402 134.671 1.00 66.96 ? 33 GLY F C   1 
ATOM   1319 O O   . GLY F 1 33 ? 155.481 117.014 135.639 1.00 66.96 ? 33 GLY F O   1 
ATOM   1320 N N   . SER F 1 34 ? 157.238 116.166 134.522 1.00 66.15 ? 34 SER F N   1 
ATOM   1321 C CA  . SER F 1 34 ? 158.231 116.661 135.472 1.00 66.15 ? 34 SER F CA  1 
ATOM   1322 C C   . SER F 1 34 ? 158.530 118.119 135.157 1.00 66.15 ? 34 SER F C   1 
ATOM   1323 O O   . SER F 1 34 ? 159.063 118.443 134.093 1.00 66.15 ? 34 SER F O   1 
ATOM   1324 C CB  . SER F 1 34 ? 159.495 115.812 135.412 1.00 66.15 ? 34 SER F CB  1 
ATOM   1325 O OG  . SER F 1 34 ? 160.474 116.291 136.318 1.00 66.15 ? 34 SER F OG  1 
ATOM   1326 N N   . ASN F 1 35 ? 158.179 119.011 136.079 1.00 62.87 ? 35 ASN F N   1 
ATOM   1327 C CA  . ASN F 1 35 ? 158.410 120.435 135.906 1.00 62.87 ? 35 ASN F CA  1 
ATOM   1328 C C   . ASN F 1 35 ? 159.497 120.919 136.855 1.00 62.87 ? 35 ASN F C   1 
ATOM   1329 O O   . ASN F 1 35 ? 159.560 120.498 138.013 1.00 62.87 ? 35 ASN F O   1 
ATOM   1330 C CB  . ASN F 1 35 ? 157.123 121.223 136.146 1.00 62.87 ? 35 ASN F CB  1 
ATOM   1331 C CG  . ASN F 1 35 ? 157.297 122.705 135.905 1.00 62.87 ? 35 ASN F CG  1 
ATOM   1332 O OD1 . ASN F 1 35 ? 157.225 123.172 134.772 1.00 62.87 ? 35 ASN F OD1 1 
ATOM   1333 N ND2 . ASN F 1 35 ? 157.532 123.450 136.974 1.00 62.87 ? 35 ASN F ND2 1 
ATOM   1334 N N   . THR F 1 36 ? 160.361 121.800 136.354 1.00 61.48 ? 36 THR F N   1 
ATOM   1335 C CA  . THR F 1 36 ? 161.447 122.346 137.153 1.00 61.48 ? 36 THR F CA  1 
ATOM   1336 C C   . THR F 1 36 ? 161.668 123.801 136.772 1.00 61.48 ? 36 THR F C   1 
ATOM   1337 O O   . THR F 1 36 ? 161.643 124.150 135.589 1.00 61.48 ? 36 THR F O   1 
ATOM   1338 C CB  . THR F 1 36 ? 162.740 121.549 136.953 1.00 61.48 ? 36 THR F CB  1 
ATOM   1339 O OG1 . THR F 1 36 ? 162.476 120.152 137.135 1.00 61.48 ? 36 THR F OG1 1 
ATOM   1340 C CG2 . THR F 1 36 ? 163.797 121.989 137.953 1.00 61.48 ? 36 THR F CG2 1 
ATOM   1341 N N   . TYR F 1 37 ? 161.883 124.643 137.778 1.00 57.79 ? 37 TYR F N   1 
ATOM   1342 C CA  . TYR F 1 37 ? 162.196 126.050 137.552 1.00 57.79 ? 37 TYR F CA  1 
ATOM   1343 C C   . TYR F 1 37 ? 163.691 126.317 137.688 1.00 57.79 ? 37 TYR F C   1 
ATOM   1344 O O   . TYR F 1 37 ? 164.117 127.468 137.771 1.00 57.79 ? 37 TYR F O   1 
ATOM   1345 C CB  . TYR F 1 37 ? 161.426 126.937 138.527 1.00 57.79 ? 37 TYR F CB  1 
ATOM   1346 C CG  . TYR F 1 37 ? 159.963 127.092 138.197 1.00 57.79 ? 37 TYR F CG  1 
ATOM   1347 C CD1 . TYR F 1 37 ? 159.533 128.085 137.334 1.00 57.79 ? 37 TYR F CD1 1 
ATOM   1348 C CD2 . TYR F 1 37 ? 159.014 126.248 138.748 1.00 57.79 ? 37 TYR F CD2 1 
ATOM   1349 C CE1 . TYR F 1 37 ? 158.199 128.233 137.029 1.00 57.79 ? 37 TYR F CE1 1 
ATOM   1350 C CE2 . TYR F 1 37 ? 157.676 126.390 138.450 1.00 57.79 ? 37 TYR F CE2 1 
ATOM   1351 C CZ  . TYR F 1 37 ? 157.275 127.384 137.590 1.00 57.79 ? 37 TYR F CZ  1 
ATOM   1352 O OH  . TYR F 1 37 ? 155.944 127.533 137.289 1.00 57.79 ? 37 TYR F OH  1 
HETATM 1353 N N   . NH2 F 1 38 ? 164.480 125.249 137.707 1.00 60.94 ? 38 NH2 F N   1 
ATOM   1354 N N   . CYS G 1 2  ? 118.732 140.320 136.951 1.00 90.80 ? 2  CYS G N   1 
ATOM   1355 C CA  . CYS G 1 2  ? 119.444 139.109 136.560 1.00 90.80 ? 2  CYS G CA  1 
ATOM   1356 C C   . CYS G 1 2  ? 118.902 137.885 137.290 1.00 90.80 ? 2  CYS G C   1 
ATOM   1357 O O   . CYS G 1 2  ? 118.621 137.940 138.485 1.00 90.80 ? 2  CYS G O   1 
ATOM   1358 C CB  . CYS G 1 2  ? 120.941 139.258 136.832 1.00 90.80 ? 2  CYS G CB  1 
ATOM   1359 S SG  . CYS G 1 2  ? 121.651 140.829 136.297 1.00 90.80 ? 2  CYS G SG  1 
ATOM   1360 N N   . ASN G 1 3  ? 118.748 136.783 136.559 1.00 93.76 ? 3  ASN G N   1 
ATOM   1361 C CA  . ASN G 1 3  ? 118.297 135.514 137.119 1.00 93.76 ? 3  ASN G CA  1 
ATOM   1362 C C   . ASN G 1 3  ? 119.391 134.473 136.914 1.00 93.76 ? 3  ASN G C   1 
ATOM   1363 O O   . ASN G 1 3  ? 119.663 134.067 135.780 1.00 93.76 ? 3  ASN G O   1 
ATOM   1364 C CB  . ASN G 1 3  ? 116.986 135.065 136.476 1.00 93.76 ? 3  ASN G CB  1 
ATOM   1365 C CG  . ASN G 1 3  ? 115.823 135.969 136.829 1.00 93.76 ? 3  ASN G CG  1 
ATOM   1366 O OD1 . ASN G 1 3  ? 116.011 137.116 137.231 1.00 93.76 ? 3  ASN G OD1 1 
ATOM   1367 N ND2 . ASN G 1 3  ? 114.608 135.454 136.683 1.00 93.76 ? 3  ASN G ND2 1 
ATOM   1368 N N   . THR G 1 4  ? 120.007 134.040 138.017 1.00 90.60 ? 4  THR G N   1 
ATOM   1369 C CA  . THR G 1 4  ? 121.061 133.022 138.009 1.00 90.60 ? 4  THR G CA  1 
ATOM   1370 C C   . THR G 1 4  ? 122.171 133.380 137.022 1.00 90.60 ? 4  THR G C   1 
ATOM   1371 O O   . THR G 1 4  ? 122.738 132.515 136.351 1.00 90.60 ? 4  THR G O   1 
ATOM   1372 C CB  . THR G 1 4  ? 120.500 131.633 137.691 1.00 90.60 ? 4  THR G CB  1 
ATOM   1373 O OG1 . THR G 1 4  ? 120.426 131.472 136.274 1.00 90.60 ? 4  THR G OG1 1 
ATOM   1374 C CG2 . THR G 1 4  ? 119.107 131.449 138.275 1.00 90.60 ? 4  THR G CG2 1 
ATOM   1375 N N   . ALA G 1 5  ? 122.490 134.669 136.935 1.00 84.35 ? 5  ALA G N   1 
ATOM   1376 C CA  . ALA G 1 5  ? 123.362 135.179 135.885 1.00 84.35 ? 5  ALA G CA  1 
ATOM   1377 C C   . ALA G 1 5  ? 124.384 136.136 136.475 1.00 84.35 ? 5  ALA G C   1 
ATOM   1378 O O   . ALA G 1 5  ? 124.012 137.139 137.088 1.00 84.35 ? 5  ALA G O   1 
ATOM   1379 C CB  . ALA G 1 5  ? 122.542 135.880 134.800 1.00 84.35 ? 5  ALA G CB  1 
ATOM   1380 N N   . THR G 1 6  ? 125.665 135.847 136.264 1.00 78.58 ? 6  THR G N   1 
ATOM   1381 C CA  . THR G 1 6  ? 126.729 136.762 136.664 1.00 78.58 ? 6  THR G CA  1 
ATOM   1382 C C   . THR G 1 6  ? 126.738 137.950 135.709 1.00 78.58 ? 6  THR G C   1 
ATOM   1383 O O   . THR G 1 6  ? 127.168 137.826 134.559 1.00 78.58 ? 6  THR G O   1 
ATOM   1384 C CB  . THR G 1 6  ? 128.075 136.047 136.659 1.00 78.58 ? 6  THR G CB  1 
ATOM   1385 O OG1 . THR G 1 6  ? 128.569 135.966 135.319 1.00 78.58 ? 6  THR G OG1 1 
ATOM   1386 C CG2 . THR G 1 6  ? 127.929 134.641 137.215 1.00 78.58 ? 6  THR G CG2 1 
ATOM   1387 N N   . CYS G 1 7  ? 126.278 139.105 136.179 1.00 81.23 ? 7  CYS G N   1 
ATOM   1388 C CA  . CYS G 1 7  ? 125.967 140.241 135.317 1.00 81.23 ? 7  CYS G CA  1 
ATOM   1389 C C   . CYS G 1 7  ? 126.711 141.490 135.769 1.00 81.23 ? 7  CYS G C   1 
ATOM   1390 O O   . CYS G 1 7  ? 126.122 142.548 136.002 1.00 81.23 ? 7  CYS G O   1 
ATOM   1391 C CB  . CYS G 1 7  ? 124.462 140.490 135.249 1.00 81.23 ? 7  CYS G CB  1 
ATOM   1392 S SG  . CYS G 1 7  ? 123.611 140.674 136.808 1.00 81.23 ? 7  CYS G SG  1 
ATOM   1393 N N   . ALA G 1 8  ? 128.029 141.363 135.926 1.00 73.82 ? 8  ALA G N   1 
ATOM   1394 C CA  . ALA G 1 8  ? 128.864 142.492 136.321 1.00 73.82 ? 8  ALA G CA  1 
ATOM   1395 C C   . ALA G 1 8  ? 128.680 143.678 135.380 1.00 73.82 ? 8  ALA G C   1 
ATOM   1396 O O   . ALA G 1 8  ? 128.683 143.524 134.159 1.00 73.82 ? 8  ALA G O   1 
ATOM   1397 C CB  . ALA G 1 8  ? 130.331 142.070 136.346 1.00 73.82 ? 8  ALA G CB  1 
ATOM   1398 N N   . THR G 1 9  ? 128.518 144.868 135.957 1.00 70.04 ? 9  THR G N   1 
ATOM   1399 C CA  . THR G 1 9  ? 128.292 146.087 135.194 1.00 70.04 ? 9  THR G CA  1 
ATOM   1400 C C   . THR G 1 9  ? 129.094 147.233 135.796 1.00 70.04 ? 9  THR G C   1 
ATOM   1401 O O   . THR G 1 9  ? 129.319 147.281 137.007 1.00 70.04 ? 9  THR G O   1 
ATOM   1402 C CB  . THR G 1 9  ? 126.803 146.459 135.174 1.00 70.04 ? 9  THR G CB  1 
ATOM   1403 O OG1 . THR G 1 9  ? 126.019 145.282 134.957 1.00 70.04 ? 9  THR G OG1 1 
ATOM   1404 C CG2 . THR G 1 9  ? 126.513 147.458 134.065 1.00 70.04 ? 9  THR G CG2 1 
ATOM   1405 N N   . GLN G 1 10 ? 129.537 148.154 134.940 1.00 63.39 ? 10 GLN G N   1 
ATOM   1406 C CA  . GLN G 1 10 ? 130.081 149.423 135.406 1.00 63.39 ? 10 GLN G CA  1 
ATOM   1407 C C   . GLN G 1 10 ? 129.554 150.547 134.530 1.00 63.39 ? 10 GLN G C   1 
ATOM   1408 O O   . GLN G 1 10 ? 129.149 150.328 133.385 1.00 63.39 ? 10 GLN G O   1 
ATOM   1409 C CB  . GLN G 1 10 ? 131.614 149.460 135.415 1.00 63.39 ? 10 GLN G CB  1 
ATOM   1410 C CG  . GLN G 1 10 ? 132.315 148.566 134.424 1.00 63.39 ? 10 GLN G CG  1 
ATOM   1411 C CD  . GLN G 1 10 ? 133.820 148.626 134.598 1.00 63.39 ? 10 GLN G CD  1 
ATOM   1412 O OE1 . GLN G 1 10 ? 134.327 149.407 135.401 1.00 63.39 ? 10 GLN G OE1 1 
ATOM   1413 N NE2 . GLN G 1 10 ? 134.540 147.813 133.845 1.00 63.39 ? 10 GLN G NE2 1 
ATOM   1414 N N   . ARG G 1 11 ? 129.550 151.754 135.087 1.00 65.50 ? 11 ARG G N   1 
ATOM   1415 C CA  . ARG G 1 11 ? 129.048 152.928 134.392 1.00 65.50 ? 11 ARG G CA  1 
ATOM   1416 C C   . ARG G 1 11 ? 129.907 154.134 134.734 1.00 65.50 ? 11 ARG G C   1 
ATOM   1417 O O   . ARG G 1 11 ? 130.261 154.346 135.897 1.00 65.50 ? 11 ARG G O   1 
ATOM   1418 C CB  . ARG G 1 11 ? 127.588 153.213 134.757 1.00 65.50 ? 11 ARG G CB  1 
ATOM   1419 C CG  . ARG G 1 11 ? 126.590 152.278 134.106 1.00 65.50 ? 11 ARG G CG  1 
ATOM   1420 C CD  . ARG G 1 11 ? 125.166 152.757 134.331 1.00 65.50 ? 11 ARG G CD  1 
ATOM   1421 N NE  . ARG G 1 11 ? 124.190 151.924 133.638 1.00 65.50 ? 11 ARG G NE  1 
ATOM   1422 C CZ  . ARG G 1 11 ? 122.888 152.169 133.604 1.00 65.50 ? 11 ARG G CZ  1 
ATOM   1423 N NH1 . ARG G 1 11 ? 122.367 153.223 134.209 1.00 65.50 ? 11 ARG G NH1 1 
ATOM   1424 N NH2 . ARG G 1 11 ? 122.088 151.335 132.944 1.00 65.50 ? 11 ARG G NH2 1 
ATOM   1425 N N   . LEU G 1 12 ? 130.238 154.920 133.715 1.00 64.37 ? 12 LEU G N   1 
ATOM   1426 C CA  . LEU G 1 12 ? 130.913 156.201 133.878 1.00 64.37 ? 12 LEU G CA  1 
ATOM   1427 C C   . LEU G 1 12 ? 130.122 157.241 133.103 1.00 64.37 ? 12 LEU G C   1 
ATOM   1428 O O   . LEU G 1 12 ? 129.811 157.029 131.927 1.00 64.37 ? 12 LEU G O   1 
ATOM   1429 C CB  . LEU G 1 12 ? 132.361 156.137 133.380 1.00 64.37 ? 12 LEU G CB  1 
ATOM   1430 C CG  . LEU G 1 12 ? 133.358 155.304 134.190 1.00 64.37 ? 12 LEU G CG  1 
ATOM   1431 C CD1 . LEU G 1 12 ? 133.318 153.846 133.778 1.00 64.37 ? 12 LEU G CD1 1 
ATOM   1432 C CD2 . LEU G 1 12 ? 134.761 155.854 134.025 1.00 64.37 ? 12 LEU G CD2 1 
ATOM   1433 N N   . ALA G 1 13 ? 129.787 158.355 133.749 1.00 70.00 ? 13 ALA G N   1 
ATOM   1434 C CA  . ALA G 1 13 ? 128.907 159.313 133.097 1.00 70.00 ? 13 ALA G CA  1 
ATOM   1435 C C   . ALA G 1 13 ? 129.126 160.711 133.657 1.00 70.00 ? 13 ALA G C   1 
ATOM   1436 O O   . ALA G 1 13 ? 129.558 160.886 134.798 1.00 70.00 ? 13 ALA G O   1 
ATOM   1437 C CB  . ALA G 1 13 ? 127.437 158.908 133.246 1.00 70.00 ? 13 ALA G CB  1 
ATOM   1438 N N   . ASN G 1 14 ? 128.816 161.701 132.817 1.00 73.26 ? 14 ASN G N   1 
ATOM   1439 C CA  . ASN G 1 14 ? 128.726 163.108 133.209 1.00 73.26 ? 14 ASN G CA  1 
ATOM   1440 C C   . ASN G 1 14 ? 129.990 163.595 133.910 1.00 73.26 ? 14 ASN G C   1 
ATOM   1441 O O   . ASN G 1 14 ? 129.939 164.296 134.920 1.00 73.26 ? 14 ASN G O   1 
ATOM   1442 C CB  . ASN G 1 14 ? 127.495 163.343 134.084 1.00 73.26 ? 14 ASN G CB  1 
ATOM   1443 C CG  . ASN G 1 14 ? 126.239 162.742 133.490 1.00 73.26 ? 14 ASN G CG  1 
ATOM   1444 O OD1 . ASN G 1 14 ? 125.703 163.245 132.503 1.00 73.26 ? 14 ASN G OD1 1 
ATOM   1445 N ND2 . ASN G 1 14 ? 125.759 161.661 134.093 1.00 73.26 ? 14 ASN G ND2 1 
ATOM   1446 N N   . PHE G 1 15 ? 131.144 163.234 133.356 1.00 71.42 ? 15 PHE G N   1 
ATOM   1447 C CA  . PHE G 1 15 ? 132.413 163.626 133.949 1.00 71.42 ? 15 PHE G CA  1 
ATOM   1448 C C   . PHE G 1 15 ? 133.273 164.359 132.929 1.00 71.42 ? 15 PHE G C   1 
ATOM   1449 O O   . PHE G 1 15 ? 132.910 164.502 131.762 1.00 71.42 ? 15 PHE G O   1 
ATOM   1450 C CB  . PHE G 1 15 ? 133.165 162.418 134.517 1.00 71.42 ? 15 PHE G CB  1 
ATOM   1451 C CG  . PHE G 1 15 ? 133.547 161.394 133.493 1.00 71.42 ? 15 PHE G CG  1 
ATOM   1452 C CD1 . PHE G 1 15 ? 132.660 160.398 133.124 1.00 71.42 ? 15 PHE G CD1 1 
ATOM   1453 C CD2 . PHE G 1 15 ? 134.809 161.405 132.922 1.00 71.42 ? 15 PHE G CD2 1 
ATOM   1454 C CE1 . PHE G 1 15 ? 133.015 159.447 132.191 1.00 71.42 ? 15 PHE G CE1 1 
ATOM   1455 C CE2 . PHE G 1 15 ? 135.169 160.457 131.987 1.00 71.42 ? 15 PHE G CE2 1 
ATOM   1456 C CZ  . PHE G 1 15 ? 134.272 159.475 131.623 1.00 71.42 ? 15 PHE G CZ  1 
ATOM   1457 N N   . LEU G 1 16 ? 134.415 164.849 133.401 1.00 72.35 ? 16 LEU G N   1 
ATOM   1458 C CA  . LEU G 1 16 ? 135.380 165.547 132.559 1.00 72.35 ? 16 LEU G CA  1 
ATOM   1459 C C   . LEU G 1 16 ? 136.779 165.210 133.045 1.00 72.35 ? 16 LEU G C   1 
ATOM   1460 O O   . LEU G 1 16 ? 137.074 165.351 134.234 1.00 72.35 ? 16 LEU G O   1 
ATOM   1461 C CB  . LEU G 1 16 ? 135.167 167.064 132.594 1.00 72.35 ? 16 LEU G CB  1 
ATOM   1462 C CG  . LEU G 1 16 ? 133.915 167.624 131.919 1.00 72.35 ? 16 LEU G CG  1 
ATOM   1463 C CD1 . LEU G 1 16 ? 132.790 167.801 132.926 1.00 72.35 ? 16 LEU G CD1 1 
ATOM   1464 C CD2 . LEU G 1 16 ? 134.227 168.940 131.225 1.00 72.35 ? 16 LEU G CD2 1 
ATOM   1465 N N   . VAL G 1 17 ? 137.633 164.768 132.131 1.00 69.22 ? 17 VAL G N   1 
ATOM   1466 C CA  . VAL G 1 17 ? 139.007 164.401 132.448 1.00 69.22 ? 17 VAL G CA  1 
ATOM   1467 C C   . VAL G 1 17 ? 139.909 165.290 131.603 1.00 69.22 ? 17 VAL G C   1 
ATOM   1468 O O   . VAL G 1 17 ? 139.805 165.307 130.371 1.00 69.22 ? 17 VAL G O   1 
ATOM   1469 C CB  . VAL G 1 17 ? 139.290 162.917 132.196 1.00 69.22 ? 17 VAL G CB  1 
ATOM   1470 C CG1 . VAL G 1 17 ? 140.747 162.604 132.476 1.00 69.22 ? 17 VAL G CG1 1 
ATOM   1471 C CG2 . VAL G 1 17 ? 138.388 162.059 133.058 1.00 69.22 ? 17 VAL G CG2 1 
ATOM   1472 N N   . HIS G 1 18 ? 140.789 166.039 132.257 1.00 73.46 ? 18 HIS G N   1 
ATOM   1473 C CA  . HIS G 1 18 ? 141.750 166.887 131.569 1.00 73.46 ? 18 HIS G CA  1 
ATOM   1474 C C   . HIS G 1 18 ? 143.156 166.418 131.917 1.00 73.46 ? 18 HIS G C   1 
ATOM   1475 O O   . HIS G 1 18 ? 143.497 166.287 133.097 1.00 73.46 ? 18 HIS G O   1 
ATOM   1476 C CB  . HIS G 1 18 ? 141.551 168.350 131.959 1.00 73.46 ? 18 HIS G CB  1 
ATOM   1477 C CG  . HIS G 1 18 ? 142.308 169.314 131.099 1.00 73.46 ? 18 HIS G CG  1 
ATOM   1478 N ND1 . HIS G 1 18 ? 143.682 169.378 131.084 1.00 73.46 ? 18 HIS G ND1 1 
ATOM   1479 C CD2 . HIS G 1 18 ? 141.877 170.254 130.227 1.00 73.46 ? 18 HIS G CD2 1 
ATOM   1480 C CE1 . HIS G 1 18 ? 144.069 170.315 130.238 1.00 73.46 ? 18 HIS G CE1 1 
ATOM   1481 N NE2 . HIS G 1 18 ? 142.994 170.863 129.705 1.00 73.46 ? 18 HIS G NE2 1 
ATOM   1482 N N   . SER G 1 19 ? 143.967 166.164 130.896 1.00 68.99 ? 19 SER G N   1 
ATOM   1483 C CA  . SER G 1 19 ? 145.326 165.685 131.085 1.00 68.99 ? 19 SER G CA  1 
ATOM   1484 C C   . SER G 1 19 ? 146.290 166.535 130.273 1.00 68.99 ? 19 SER G C   1 
ATOM   1485 O O   . SER G 1 19 ? 145.933 167.077 129.224 1.00 68.99 ? 19 SER G O   1 
ATOM   1486 C CB  . SER G 1 19 ? 145.467 164.216 130.683 1.00 68.99 ? 19 SER G CB  1 
ATOM   1487 O OG  . SER G 1 19 ? 146.799 163.769 130.855 1.00 68.99 ? 19 SER G OG  1 
ATOM   1488 N N   . SER G 1 20 ? 147.517 166.647 130.772 1.00 71.47 ? 20 SER G N   1 
ATOM   1489 C CA  . SER G 1 20 ? 148.559 167.428 130.116 1.00 71.47 ? 20 SER G CA  1 
ATOM   1490 C C   . SER G 1 20 ? 149.715 166.564 129.641 1.00 71.47 ? 20 SER G C   1 
ATOM   1491 O O   . SER G 1 20 ? 150.180 166.724 128.507 1.00 71.47 ? 20 SER G O   1 
ATOM   1492 C CB  . SER G 1 20 ? 149.071 168.523 131.063 1.00 71.47 ? 20 SER G CB  1 
ATOM   1493 O OG  . SER G 1 20 ? 148.020 169.396 131.440 1.00 71.47 ? 20 SER G OG  1 
ATOM   1494 N N   . ASN G 1 21 ? 150.206 165.662 130.484 1.00 71.76 ? 21 ASN G N   1 
ATOM   1495 C CA  . ASN G 1 21 ? 151.201 164.673 130.096 1.00 71.76 ? 21 ASN G CA  1 
ATOM   1496 C C   . ASN G 1 21 ? 150.816 163.351 130.733 1.00 71.76 ? 21 ASN G C   1 
ATOM   1497 O O   . ASN G 1 21 ? 150.378 163.324 131.888 1.00 71.76 ? 21 ASN G O   1 
ATOM   1498 C CB  . ASN G 1 21 ? 152.605 165.093 130.532 1.00 71.76 ? 21 ASN G CB  1 
ATOM   1499 C CG  . ASN G 1 21 ? 153.680 164.180 129.980 1.00 71.76 ? 21 ASN G CG  1 
ATOM   1500 O OD1 . ASN G 1 21 ? 154.028 163.169 130.589 1.00 71.76 ? 21 ASN G OD1 1 
ATOM   1501 N ND2 . ASN G 1 21 ? 154.223 164.543 128.824 1.00 71.76 ? 21 ASN G ND2 1 
ATOM   1502 N N   . ASN G 1 22 ? 150.975 162.256 129.994 1.00 73.01 ? 22 ASN G N   1 
ATOM   1503 C CA  . ASN G 1 22 ? 150.565 160.957 130.502 1.00 73.01 ? 22 ASN G CA  1 
ATOM   1504 C C   . ASN G 1 22 ? 151.409 159.859 129.875 1.00 73.01 ? 22 ASN G C   1 
ATOM   1505 O O   . ASN G 1 22 ? 151.700 159.886 128.677 1.00 73.01 ? 22 ASN G O   1 
ATOM   1506 C CB  . ASN G 1 22 ? 149.084 160.691 130.233 1.00 73.01 ? 22 ASN G CB  1 
ATOM   1507 C CG  . ASN G 1 22 ? 148.692 159.265 130.538 1.00 73.01 ? 22 ASN G CG  1 
ATOM   1508 O OD1 . ASN G 1 22 ? 148.463 158.904 131.691 1.00 73.01 ? 22 ASN G OD1 1 
ATOM   1509 N ND2 . ASN G 1 22 ? 148.618 158.438 129.502 1.00 73.01 ? 22 ASN G ND2 1 
ATOM   1510 N N   . PHE G 1 23 ? 151.793 158.890 130.703 1.00 75.52 ? 23 PHE G N   1 
ATOM   1511 C CA  . PHE G 1 23 ? 152.548 157.727 130.249 1.00 75.52 ? 23 PHE G CA  1 
ATOM   1512 C C   . PHE G 1 23 ? 151.818 156.406 130.437 1.00 75.52 ? 23 PHE G C   1 
ATOM   1513 O O   . PHE G 1 23 ? 152.345 155.373 130.010 1.00 75.52 ? 23 PHE G O   1 
ATOM   1514 C CB  . PHE G 1 23 ? 153.901 157.643 130.972 1.00 75.52 ? 23 PHE G CB  1 
ATOM   1515 C CG  . PHE G 1 23 ? 154.976 158.500 130.363 1.00 75.52 ? 23 PHE G CG  1 
ATOM   1516 C CD1 . PHE G 1 23 ? 154.655 159.643 129.650 1.00 75.52 ? 23 PHE G CD1 1 
ATOM   1517 C CD2 . PHE G 1 23 ? 156.310 158.165 130.508 1.00 75.52 ? 23 PHE G CD2 1 
ATOM   1518 C CE1 . PHE G 1 23 ? 155.640 160.432 129.096 1.00 75.52 ? 23 PHE G CE1 1 
ATOM   1519 C CE2 . PHE G 1 23 ? 157.300 158.950 129.955 1.00 75.52 ? 23 PHE G CE2 1 
ATOM   1520 C CZ  . PHE G 1 23 ? 156.966 160.084 129.247 1.00 75.52 ? 23 PHE G CZ  1 
ATOM   1521 N N   . GLY G 1 24 ? 150.648 156.397 131.070 1.00 76.04 ? 24 GLY G N   1 
ATOM   1522 C CA  . GLY G 1 24 ? 149.888 155.176 131.260 1.00 76.04 ? 24 GLY G CA  1 
ATOM   1523 C C   . GLY G 1 24 ? 148.421 155.351 130.929 1.00 76.04 ? 24 GLY G C   1 
ATOM   1524 O O   . GLY G 1 24 ? 148.034 156.356 130.326 1.00 76.04 ? 24 GLY G O   1 
ATOM   1525 N N   . ALA G 1 25 ? 147.594 154.382 131.309 1.00 73.14 ? 25 ALA G N   1 
ATOM   1526 C CA  . ALA G 1 25 ? 146.162 154.492 131.077 1.00 73.14 ? 25 ALA G CA  1 
ATOM   1527 C C   . ALA G 1 25 ? 145.569 155.609 131.925 1.00 73.14 ? 25 ALA G C   1 
ATOM   1528 O O   . ALA G 1 25 ? 146.085 155.941 132.991 1.00 73.14 ? 25 ALA G O   1 
ATOM   1529 C CB  . ALA G 1 25 ? 145.468 153.169 131.397 1.00 73.14 ? 25 ALA G CB  1 
ATOM   1530 N N   . ILE G 1 26 ? 144.488 156.214 131.433 1.00 73.31 ? 26 ILE G N   1 
ATOM   1531 C CA  . ILE G 1 26 ? 143.777 157.179 132.263 1.00 73.31 ? 26 ILE G CA  1 
ATOM   1532 C C   . ILE G 1 26 ? 142.318 156.772 132.387 1.00 73.31 ? 26 ILE G C   1 
ATOM   1533 O O   . ILE G 1 26 ? 141.663 157.093 133.383 1.00 73.31 ? 26 ILE G O   1 
ATOM   1534 C CB  . ILE G 1 26 ? 143.905 158.621 131.732 1.00 73.31 ? 26 ILE G CB  1 
ATOM   1535 C CG1 . ILE G 1 26 ? 142.908 158.890 130.609 1.00 73.31 ? 26 ILE G CG1 1 
ATOM   1536 C CG2 . ILE G 1 26 ? 145.317 158.904 131.259 1.00 73.31 ? 26 ILE G CG2 1 
ATOM   1537 C CD1 . ILE G 1 26 ? 142.783 160.351 130.251 1.00 73.31 ? 26 ILE G CD1 1 
ATOM   1538 N N   . LEU G 1 27 ? 141.790 156.060 131.390 1.00 69.27 ? 27 LEU G N   1 
ATOM   1539 C CA  . LEU G 1 27 ? 140.451 155.482 131.525 1.00 69.27 ? 27 LEU G CA  1 
ATOM   1540 C C   . LEU G 1 27 ? 140.465 154.125 130.820 1.00 69.27 ? 27 LEU G C   1 
ATOM   1541 O O   . LEU G 1 27 ? 140.156 154.027 129.633 1.00 69.27 ? 27 LEU G O   1 
ATOM   1542 C CB  . LEU G 1 27 ? 139.370 156.390 130.957 1.00 69.27 ? 27 LEU G CB  1 
ATOM   1543 C CG  . LEU G 1 27 ? 138.722 157.431 131.872 1.00 69.27 ? 27 LEU G CG  1 
ATOM   1544 C CD1 . LEU G 1 27 ? 139.474 158.743 131.812 1.00 69.27 ? 27 LEU G CD1 1 
ATOM   1545 C CD2 . LEU G 1 27 ? 137.268 157.630 131.506 1.00 69.27 ? 27 LEU G CD2 1 
ATOM   1546 N N   . SER G 1 28 ? 140.797 153.080 131.570 1.00 69.58 ? 28 SER G N   1 
ATOM   1547 C CA  . SER G 1 28 ? 140.771 151.709 131.061 1.00 69.58 ? 28 SER G CA  1 
ATOM   1548 C C   . SER G 1 28 ? 140.137 150.797 132.101 1.00 69.58 ? 28 SER G C   1 
ATOM   1549 O O   . SER G 1 28 ? 140.801 149.928 132.677 1.00 69.58 ? 28 SER G O   1 
ATOM   1550 C CB  . SER G 1 28 ? 142.178 151.241 130.692 1.00 69.58 ? 28 SER G CB  1 
ATOM   1551 O OG  . SER G 1 28 ? 142.811 152.183 129.848 1.00 69.58 ? 28 SER G OG  1 
ATOM   1552 N N   . PRO G 1 29 ? 138.845 150.968 132.368 1.00 65.34 ? 29 PRO G N   1 
ATOM   1553 C CA  . PRO G 1 29 ? 138.175 150.058 133.299 1.00 65.34 ? 29 PRO G CA  1 
ATOM   1554 C C   . PRO G 1 29 ? 138.102 148.654 132.723 1.00 65.34 ? 29 PRO G C   1 
ATOM   1555 O O   . PRO G 1 29 ? 138.013 148.465 131.509 1.00 65.34 ? 29 PRO G O   1 
ATOM   1556 C CB  . PRO G 1 29 ? 136.781 150.674 133.460 1.00 65.34 ? 29 PRO G CB  1 
ATOM   1557 C CG  . PRO G 1 29 ? 136.576 151.457 132.227 1.00 65.34 ? 29 PRO G CG  1 
ATOM   1558 C CD  . PRO G 1 29 ? 137.918 151.969 131.816 1.00 65.34 ? 29 PRO G CD  1 
ATOM   1559 N N   . THR G 1 30 ? 138.148 147.665 133.610 1.00 65.63 ? 30 THR G N   1 
ATOM   1560 C CA  . THR G 1 30 ? 138.093 146.262 133.226 1.00 65.63 ? 30 THR G CA  1 
ATOM   1561 C C   . THR G 1 30 ? 136.813 145.649 133.767 1.00 65.63 ? 30 THR G C   1 
ATOM   1562 O O   . THR G 1 30 ? 136.533 145.748 134.966 1.00 65.63 ? 30 THR G O   1 
ATOM   1563 C CB  . THR G 1 30 ? 139.309 145.494 133.750 1.00 65.63 ? 30 THR G CB  1 
ATOM   1564 O OG1 . THR G 1 30 ? 140.508 146.086 133.237 1.00 65.63 ? 30 THR G OG1 1 
ATOM   1565 C CG2 . THR G 1 30 ? 139.245 144.041 133.321 1.00 65.63 ? 30 THR G CG2 1 
ATOM   1566 N N   . ASN G 1 31 ? 136.040 145.023 132.885 1.00 62.46 ? 31 ASN G N   1 
ATOM   1567 C CA  . ASN G 1 31 ? 134.795 144.366 133.260 1.00 62.46 ? 31 ASN G CA  1 
ATOM   1568 C C   . ASN G 1 31 ? 134.869 142.916 132.814 1.00 62.46 ? 31 ASN G C   1 
ATOM   1569 O O   . ASN G 1 31 ? 135.044 142.641 131.624 1.00 62.46 ? 31 ASN G O   1 
ATOM   1570 C CB  . ASN G 1 31 ? 133.590 145.060 132.626 1.00 62.46 ? 31 ASN G CB  1 
ATOM   1571 C CG  . ASN G 1 31 ? 132.280 144.581 133.198 1.00 62.46 ? 31 ASN G CG  1 
ATOM   1572 O OD1 . ASN G 1 31 ? 132.248 143.917 134.231 1.00 62.46 ? 31 ASN G OD1 1 
ATOM   1573 N ND2 . ASN G 1 31 ? 131.189 144.920 132.533 1.00 62.46 ? 31 ASN G ND2 1 
ATOM   1574 N N   . VAL G 1 32 ? 134.737 141.995 133.763 1.00 60.49 ? 32 VAL G N   1 
ATOM   1575 C CA  . VAL G 1 32 ? 134.776 140.568 133.480 1.00 60.49 ? 32 VAL G CA  1 
ATOM   1576 C C   . VAL G 1 32 ? 133.540 139.928 134.091 1.00 60.49 ? 32 VAL G C   1 
ATOM   1577 O O   . VAL G 1 32 ? 133.324 140.020 135.304 1.00 60.49 ? 32 VAL G O   1 
ATOM   1578 C CB  . VAL G 1 32 ? 136.055 139.911 134.029 1.00 60.49 ? 32 VAL G CB  1 
ATOM   1579 C CG1 . VAL G 1 32 ? 135.948 138.398 133.951 1.00 60.49 ? 32 VAL G CG1 1 
ATOM   1580 C CG2 . VAL G 1 32 ? 137.269 140.403 133.262 1.00 60.49 ? 32 VAL G CG2 1 
ATOM   1581 N N   . GLY G 1 33 ? 132.728 139.289 133.252 1.00 61.00 ? 33 GLY G N   1 
ATOM   1582 C CA  . GLY G 1 33 ? 131.536 138.627 133.756 1.00 61.00 ? 33 GLY G CA  1 
ATOM   1583 C C   . GLY G 1 33 ? 131.858 137.445 134.649 1.00 61.00 ? 33 GLY G C   1 
ATOM   1584 O O   . GLY G 1 33 ? 131.227 137.252 135.689 1.00 61.00 ? 33 GLY G O   1 
ATOM   1585 N N   . SER G 1 34 ? 132.842 136.638 134.255 1.00 59.91 ? 34 SER G N   1 
ATOM   1586 C CA  . SER G 1 34 ? 133.239 135.477 135.037 1.00 59.91 ? 34 SER G CA  1 
ATOM   1587 C C   . SER G 1 34 ? 134.607 135.012 134.568 1.00 59.91 ? 34 SER G C   1 
ATOM   1588 O O   . SER G 1 34 ? 134.959 135.159 133.397 1.00 59.91 ? 34 SER G O   1 
ATOM   1589 C CB  . SER G 1 34 ? 132.221 134.341 134.911 1.00 59.91 ? 34 SER G CB  1 
ATOM   1590 O OG  . SER G 1 34 ? 132.155 133.868 133.579 1.00 59.91 ? 34 SER G OG  1 
ATOM   1591 N N   . ASN G 1 35 ? 135.373 134.451 135.499 1.00 64.80 ? 35 ASN G N   1 
ATOM   1592 C CA  . ASN G 1 35 ? 136.702 133.910 135.220 1.00 64.80 ? 35 ASN G CA  1 
ATOM   1593 C C   . ASN G 1 35 ? 136.765 132.500 135.793 1.00 64.80 ? 35 ASN G C   1 
ATOM   1594 O O   . ASN G 1 35 ? 136.785 132.315 137.012 1.00 64.80 ? 35 ASN G O   1 
ATOM   1595 C CB  . ASN G 1 35 ? 137.794 134.793 135.805 1.00 64.80 ? 35 ASN G CB  1 
ATOM   1596 C CG  . ASN G 1 35 ? 139.169 134.429 135.290 1.00 64.80 ? 35 ASN G CG  1 
ATOM   1597 O OD1 . ASN G 1 35 ? 139.333 133.452 134.563 1.00 64.80 ? 35 ASN G OD1 1 
ATOM   1598 N ND2 . ASN G 1 35 ? 140.166 135.201 135.685 1.00 64.80 ? 35 ASN G ND2 1 
ATOM   1599 N N   . THR G 1 36 ? 136.798 131.504 134.914 1.00 67.27 ? 36 THR G N   1 
ATOM   1600 C CA  . THR G 1 36 ? 136.906 130.111 135.328 1.00 67.27 ? 36 THR G CA  1 
ATOM   1601 C C   . THR G 1 36 ? 138.338 129.643 135.099 1.00 67.27 ? 36 THR G C   1 
ATOM   1602 O O   . THR G 1 36 ? 138.879 129.787 133.999 1.00 67.27 ? 36 THR G O   1 
ATOM   1603 C CB  . THR G 1 36 ? 135.912 129.242 134.564 1.00 67.27 ? 36 THR G CB  1 
ATOM   1604 O OG1 . THR G 1 36 ? 134.577 129.614 134.923 1.00 67.27 ? 36 THR G OG1 1 
ATOM   1605 C CG2 . THR G 1 36 ? 136.126 127.775 134.899 1.00 67.27 ? 36 THR G CG2 1 
ATOM   1606 N N   . TYR G 1 37 ? 138.950 129.094 136.141 1.00 68.49 ? 37 TYR G N   1 
ATOM   1607 C CA  . TYR G 1 37 ? 140.277 128.501 136.049 1.00 68.49 ? 37 TYR G CA  1 
ATOM   1608 C C   . TYR G 1 37 ? 140.261 127.110 136.672 1.00 68.49 ? 37 TYR G C   1 
ATOM   1609 O O   . TYR G 1 37 ? 141.085 126.791 137.528 1.00 68.49 ? 37 TYR G O   1 
ATOM   1610 C CB  . TYR G 1 37 ? 141.314 129.389 136.737 1.00 68.49 ? 37 TYR G CB  1 
ATOM   1611 C CG  . TYR G 1 37 ? 142.748 129.113 136.342 1.00 68.49 ? 37 TYR G CG  1 
ATOM   1612 C CD1 . TYR G 1 37 ? 143.069 128.074 135.480 1.00 68.49 ? 37 TYR G CD1 1 
ATOM   1613 C CD2 . TYR G 1 37 ? 143.783 129.881 136.847 1.00 68.49 ? 37 TYR G CD2 1 
ATOM   1614 C CE1 . TYR G 1 37 ? 144.378 127.817 135.129 1.00 68.49 ? 37 TYR G CE1 1 
ATOM   1615 C CE2 . TYR G 1 37 ? 145.092 129.631 136.501 1.00 68.49 ? 37 TYR G CE2 1 
ATOM   1616 C CZ  . TYR G 1 37 ? 145.385 128.599 135.642 1.00 68.49 ? 37 TYR G CZ  1 
ATOM   1617 O OH  . TYR G 1 37 ? 146.691 128.349 135.294 1.00 68.49 ? 37 TYR G OH  1 
HETATM 1618 N N   . NH2 G 1 38 ? 139.313 126.286 136.238 1.00 69.60 ? 38 NH2 G N   1 
ATOM   1619 N N   . ALA H 1 13 ? 168.946 132.138 132.519 1.00 44.34 ? 13 ALA H N   1 
ATOM   1620 C CA  . ALA H 1 13 ? 167.755 132.441 131.733 1.00 44.34 ? 13 ALA H CA  1 
ATOM   1621 C C   . ALA H 1 13 ? 166.858 133.427 132.468 1.00 44.34 ? 13 ALA H C   1 
ATOM   1622 O O   . ALA H 1 13 ? 166.072 133.041 133.329 1.00 44.34 ? 13 ALA H O   1 
ATOM   1623 C CB  . ALA H 1 13 ? 166.994 131.170 131.416 1.00 44.34 ? 13 ALA H CB  1 
ATOM   1624 N N   . ASN H 1 14 ? 166.976 134.705 132.119 1.00 45.28 ? 14 ASN H N   1 
ATOM   1625 C CA  . ASN H 1 14 ? 166.202 135.743 132.781 1.00 45.28 ? 14 ASN H CA  1 
ATOM   1626 C C   . ASN H 1 14 ? 164.824 135.870 132.148 1.00 45.28 ? 14 ASN H C   1 
ATOM   1627 O O   . ASN H 1 14 ? 164.680 135.834 130.926 1.00 45.28 ? 14 ASN H O   1 
ATOM   1628 C CB  . ASN H 1 14 ? 166.934 137.081 132.710 1.00 45.28 ? 14 ASN H CB  1 
ATOM   1629 C CG  . ASN H 1 14 ? 168.344 137.000 133.251 1.00 45.28 ? 14 ASN H CG  1 
ATOM   1630 O OD1 . ASN H 1 14 ? 168.934 135.923 133.312 1.00 45.28 ? 14 ASN H OD1 1 
ATOM   1631 N ND2 . ASN H 1 14 ? 168.890 138.139 133.653 1.00 45.28 ? 14 ASN H ND2 1 
ATOM   1632 N N   . PHE H 1 15 ? 163.810 136.022 132.994 1.00 44.94 ? 15 PHE H N   1 
ATOM   1633 C CA  . PHE H 1 15 ? 162.428 136.162 132.561 1.00 44.94 ? 15 PHE H CA  1 
ATOM   1634 C C   . PHE H 1 15 ? 161.880 137.482 133.074 1.00 44.94 ? 15 PHE H C   1 
ATOM   1635 O O   . PHE H 1 15 ? 162.043 137.807 134.254 1.00 44.94 ? 15 PHE H O   1 
ATOM   1636 C CB  . PHE H 1 15 ? 161.574 135.003 133.072 1.00 44.94 ? 15 PHE H CB  1 
ATOM   1637 C CG  . PHE H 1 15 ? 161.916 133.679 132.458 1.00 44.94 ? 15 PHE H CG  1 
ATOM   1638 C CD1 . PHE H 1 15 ? 162.975 132.934 132.940 1.00 44.94 ? 15 PHE H CD1 1 
ATOM   1639 C CD2 . PHE H 1 15 ? 161.169 133.174 131.413 1.00 44.94 ? 15 PHE H CD2 1 
ATOM   1640 C CE1 . PHE H 1 15 ? 163.291 131.716 132.382 1.00 44.94 ? 15 PHE H CE1 1 
ATOM   1641 C CE2 . PHE H 1 15 ? 161.480 131.956 130.852 1.00 44.94 ? 15 PHE H CE2 1 
ATOM   1642 C CZ  . PHE H 1 15 ? 162.543 131.226 131.339 1.00 44.94 ? 15 PHE H CZ  1 
ATOM   1643 N N   . LEU H 1 16 ? 161.245 138.245 132.191 1.00 42.74 ? 16 LEU H N   1 
ATOM   1644 C CA  . LEU H 1 16 ? 160.620 139.505 132.569 1.00 42.74 ? 16 LEU H CA  1 
ATOM   1645 C C   . LEU H 1 16 ? 159.242 139.582 131.938 1.00 42.74 ? 16 LEU H C   1 
ATOM   1646 O O   . LEU H 1 16 ? 159.099 139.380 130.729 1.00 42.74 ? 16 LEU H O   1 
ATOM   1647 C CB  . LEU H 1 16 ? 161.465 140.706 132.132 1.00 42.74 ? 16 LEU H CB  1 
ATOM   1648 C CG  . LEU H 1 16 ? 162.755 140.978 132.906 1.00 42.74 ? 16 LEU H CG  1 
ATOM   1649 C CD1 . LEU H 1 16 ? 163.926 140.222 132.305 1.00 42.74 ? 16 LEU H CD1 1 
ATOM   1650 C CD2 . LEU H 1 16 ? 163.038 142.470 132.941 1.00 42.74 ? 16 LEU H CD2 1 
ATOM   1651 N N   . VAL H 1 17 ? 158.231 139.868 132.751 1.00 39.99 ? 17 VAL H N   1 
ATOM   1652 C CA  . VAL H 1 17 ? 156.861 140.010 132.276 1.00 39.99 ? 17 VAL H CA  1 
ATOM   1653 C C   . VAL H 1 17 ? 156.298 141.309 132.830 1.00 39.99 ? 17 VAL H C   1 
ATOM   1654 O O   . VAL H 1 17 ? 156.355 141.547 134.042 1.00 39.99 ? 17 VAL H O   1 
ATOM   1655 C CB  . VAL H 1 17 ? 155.979 138.821 132.690 1.00 39.99 ? 17 VAL H CB  1 
ATOM   1656 C CG1 . VAL H 1 17 ? 154.531 139.087 132.323 1.00 39.99 ? 17 VAL H CG1 1 
ATOM   1657 C CG2 . VAL H 1 17 ? 156.468 137.544 132.033 1.00 39.99 ? 17 VAL H CG2 1 
ATOM   1658 N N   . HIS H 1 18 ? 155.764 142.147 131.948 1.00 41.68 ? 18 HIS H N   1 
ATOM   1659 C CA  . HIS H 1 18 ? 155.013 143.339 132.335 1.00 41.68 ? 18 HIS H CA  1 
ATOM   1660 C C   . HIS H 1 18 ? 153.638 143.192 131.699 1.00 41.68 ? 18 HIS H C   1 
ATOM   1661 O O   . HIS H 1 18 ? 153.386 143.707 130.608 1.00 41.68 ? 18 HIS H O   1 
ATOM   1662 C CB  . HIS H 1 18 ? 155.703 144.622 131.884 1.00 41.68 ? 18 HIS H CB  1 
ATOM   1663 C CG  . HIS H 1 18 ? 156.964 144.926 132.633 1.00 41.68 ? 18 HIS H CG  1 
ATOM   1664 N ND1 . HIS H 1 18 ? 158.080 144.121 132.570 1.00 41.68 ? 18 HIS H ND1 1 
ATOM   1665 C CD2 . HIS H 1 18 ? 157.283 145.949 133.459 1.00 41.68 ? 18 HIS H CD2 1 
ATOM   1666 C CE1 . HIS H 1 18 ? 159.034 144.635 133.324 1.00 41.68 ? 18 HIS H CE1 1 
ATOM   1667 N NE2 . HIS H 1 18 ? 158.576 145.744 133.876 1.00 41.68 ? 18 HIS H NE2 1 
ATOM   1668 N N   . SER H 1 19 ? 152.745 142.498 132.391 1.00 42.70 ? 19 SER H N   1 
ATOM   1669 C CA  . SER H 1 19 ? 151.420 142.193 131.872 1.00 42.70 ? 19 SER H CA  1 
ATOM   1670 C C   . SER H 1 19 ? 150.440 143.241 132.376 1.00 42.70 ? 19 SER H C   1 
ATOM   1671 O O   . SER H 1 19 ? 150.382 143.516 133.579 1.00 42.70 ? 19 SER H O   1 
ATOM   1672 C CB  . SER H 1 19 ? 150.983 140.792 132.295 1.00 42.70 ? 19 SER H CB  1 
ATOM   1673 O OG  . SER H 1 19 ? 149.696 140.491 131.794 1.00 42.70 ? 19 SER H OG  1 
ATOM   1674 N N   . SER H 1 20 ? 149.678 143.829 131.456 1.00 46.73 ? 20 SER H N   1 
ATOM   1675 C CA  . SER H 1 20 ? 148.695 144.833 131.843 1.00 46.73 ? 20 SER H CA  1 
ATOM   1676 C C   . SER H 1 20 ? 147.346 144.194 132.136 1.00 46.73 ? 20 SER H C   1 
ATOM   1677 O O   . SER H 1 20 ? 146.746 144.444 133.188 1.00 46.73 ? 20 SER H O   1 
ATOM   1678 C CB  . SER H 1 20 ? 148.562 145.891 130.744 1.00 46.73 ? 20 SER H CB  1 
ATOM   1679 O OG  . SER H 1 20 ? 147.577 146.854 131.076 1.00 46.73 ? 20 SER H OG  1 
ATOM   1680 N N   . ASN H 1 21 ? 146.846 143.373 131.215 1.00 47.90 ? 21 ASN H N   1 
ATOM   1681 C CA  . ASN H 1 21 ? 145.553 142.717 131.414 1.00 47.90 ? 21 ASN H CA  1 
ATOM   1682 C C   . ASN H 1 21 ? 145.612 141.367 130.697 1.00 47.90 ? 21 ASN H C   1 
ATOM   1683 O O   . ASN H 1 21 ? 145.323 141.272 129.504 1.00 47.90 ? 21 ASN H O   1 
ATOM   1684 C CB  . ASN H 1 21 ? 144.418 143.588 130.899 1.00 47.90 ? 21 ASN H CB  1 
ATOM   1685 C CG  . ASN H 1 21 ? 143.104 143.286 131.572 1.00 47.90 ? 21 ASN H CG  1 
ATOM   1686 O OD1 . ASN H 1 21 ? 142.929 142.225 132.164 1.00 47.90 ? 21 ASN H OD1 1 
ATOM   1687 N ND2 . ASN H 1 21 ? 142.171 144.226 131.492 1.00 47.90 ? 21 ASN H ND2 1 
ATOM   1688 N N   . ASN H 1 22 ? 145.963 140.330 131.446 1.00 48.43 ? 22 ASN H N   1 
ATOM   1689 C CA  . ASN H 1 22 ? 146.154 138.997 130.896 1.00 48.43 ? 22 ASN H CA  1 
ATOM   1690 C C   . ASN H 1 22 ? 144.890 138.167 131.058 1.00 48.43 ? 22 ASN H C   1 
ATOM   1691 O O   . ASN H 1 22 ? 144.247 138.182 132.109 1.00 48.43 ? 22 ASN H O   1 
ATOM   1692 C CB  . ASN H 1 22 ? 147.325 138.293 131.585 1.00 48.43 ? 22 ASN H CB  1 
ATOM   1693 C CG  . ASN H 1 22 ? 147.623 136.933 130.988 1.00 48.43 ? 22 ASN H CG  1 
ATOM   1694 O OD1 . ASN H 1 22 ? 147.051 136.545 129.972 1.00 48.43 ? 22 ASN H OD1 1 
ATOM   1695 N ND2 . ASN H 1 22 ? 148.509 136.192 131.634 1.00 48.43 ? 22 ASN H ND2 1 
ATOM   1696 N N   . PHE H 1 23 ? 144.543 137.433 130.000 1.00 47.15 ? 23 PHE H N   1 
ATOM   1697 C CA  . PHE H 1 23 ? 143.434 136.495 130.037 1.00 47.15 ? 23 PHE H CA  1 
ATOM   1698 C C   . PHE H 1 23 ? 143.832 135.102 129.571 1.00 47.15 ? 23 PHE H C   1 
ATOM   1699 O O   . PHE H 1 23 ? 142.990 134.199 129.588 1.00 47.15 ? 23 PHE H O   1 
ATOM   1700 C CB  . PHE H 1 23 ? 142.266 136.998 129.176 1.00 47.15 ? 23 PHE H CB  1 
ATOM   1701 C CG  . PHE H 1 23 ? 141.619 138.243 129.700 1.00 47.15 ? 23 PHE H CG  1 
ATOM   1702 C CD1 . PHE H 1 23 ? 142.075 139.490 129.316 1.00 47.15 ? 23 PHE H CD1 1 
ATOM   1703 C CD2 . PHE H 1 23 ? 140.556 138.170 130.577 1.00 47.15 ? 23 PHE H CD2 1 
ATOM   1704 C CE1 . PHE H 1 23 ? 141.484 140.636 129.795 1.00 47.15 ? 23 PHE H CE1 1 
ATOM   1705 C CE2 . PHE H 1 23 ? 139.959 139.315 131.058 1.00 47.15 ? 23 PHE H CE2 1 
ATOM   1706 C CZ  . PHE H 1 23 ? 140.425 140.548 130.668 1.00 47.15 ? 23 PHE H CZ  1 
ATOM   1707 N N   . GLY H 1 24 ? 145.078 134.904 129.154 1.00 48.77 ? 24 GLY H N   1 
ATOM   1708 C CA  . GLY H 1 24 ? 145.539 133.608 128.704 1.00 48.77 ? 24 GLY H CA  1 
ATOM   1709 C C   . GLY H 1 24 ? 146.882 133.232 129.286 1.00 48.77 ? 24 GLY H C   1 
ATOM   1710 O O   . GLY H 1 24 ? 147.216 133.637 130.402 1.00 48.77 ? 24 GLY H O   1 
ATOM   1711 N N   . ALA H 1 25 ? 147.663 132.457 128.541 1.00 52.11 ? 25 ALA H N   1 
ATOM   1712 C CA  . ALA H 1 25 ? 148.972 132.036 129.016 1.00 52.11 ? 25 ALA H CA  1 
ATOM   1713 C C   . ALA H 1 25 ? 150.041 133.046 128.616 1.00 52.11 ? 25 ALA H C   1 
ATOM   1714 O O   . ALA H 1 25 ? 149.880 133.805 127.659 1.00 52.11 ? 25 ALA H O   1 
ATOM   1715 C CB  . ALA H 1 25 ? 149.321 130.660 128.456 1.00 52.11 ? 25 ALA H CB  1 
ATOM   1716 N N   . ILE H 1 26 ? 151.138 133.058 129.369 1.00 52.02 ? 26 ILE H N   1 
ATOM   1717 C CA  . ILE H 1 26 ? 152.268 133.923 129.049 1.00 52.02 ? 26 ILE H CA  1 
ATOM   1718 C C   . ILE H 1 26 ? 153.517 133.077 128.860 1.00 52.02 ? 26 ILE H C   1 
ATOM   1719 O O   . ILE H 1 26 ? 154.096 133.038 127.771 1.00 52.02 ? 26 ILE H O   1 
ATOM   1720 C CB  . ILE H 1 26 ? 152.486 134.988 130.137 1.00 52.02 ? 26 ILE H CB  1 
ATOM   1721 C CG1 . ILE H 1 26 ? 151.321 135.975 130.151 1.00 52.02 ? 26 ILE H CG1 1 
ATOM   1722 C CG2 . ILE H 1 26 ? 153.787 135.726 129.902 1.00 52.02 ? 26 ILE H CG2 1 
ATOM   1723 C CD1 . ILE H 1 26 ? 151.343 136.959 129.013 1.00 52.02 ? 26 ILE H CD1 1 
ATOM   1724 N N   . LEU H 1 27 ? 153.932 132.384 129.915 1.00 55.33 ? 27 LEU H N   1 
ATOM   1725 C CA  . LEU H 1 27 ? 155.099 131.508 129.902 1.00 55.33 ? 27 LEU H CA  1 
ATOM   1726 C C   . LEU H 1 27 ? 154.736 130.161 130.509 1.00 55.33 ? 27 LEU H C   1 
ATOM   1727 O O   . LEU H 1 27 ? 155.490 129.571 131.283 1.00 55.33 ? 27 LEU H O   1 
ATOM   1728 C CB  . LEU H 1 27 ? 156.261 132.135 130.664 1.00 55.33 ? 27 LEU H CB  1 
ATOM   1729 C CG  . LEU H 1 27 ? 157.387 132.899 129.965 1.00 55.33 ? 27 LEU H CG  1 
ATOM   1730 C CD1 . LEU H 1 27 ? 158.223 131.972 129.109 1.00 55.33 ? 27 LEU H CD1 1 
ATOM   1731 C CD2 . LEU H 1 27 ? 156.858 134.058 129.152 1.00 55.33 ? 27 LEU H CD2 1 
ATOM   1732 N N   . SER H 1 28 ? 153.552 129.657 130.157 1.00 59.68 ? 28 SER H N   1 
ATOM   1733 C CA  . SER H 1 28 ? 152.938 128.512 130.829 1.00 59.68 ? 28 SER H CA  1 
ATOM   1734 C C   . SER H 1 28 ? 152.544 127.442 129.821 1.00 59.68 ? 28 SER H C   1 
ATOM   1735 O O   . SER H 1 28 ? 151.407 127.433 129.323 1.00 59.68 ? 28 SER H O   1 
ATOM   1736 C CB  . SER H 1 28 ? 151.730 128.967 131.638 1.00 59.68 ? 28 SER H CB  1 
ATOM   1737 O OG  . SER H 1 28 ? 150.728 129.482 130.784 1.00 59.68 ? 28 SER H OG  1 
ATOM   1738 N N   . PRO H 1 29 ? 153.444 126.516 129.498 1.00 62.30 ? 29 PRO H N   1 
ATOM   1739 C CA  . PRO H 1 29 ? 153.101 125.444 128.557 1.00 62.30 ? 29 PRO H CA  1 
ATOM   1740 C C   . PRO H 1 29 ? 152.010 124.535 129.105 1.00 62.30 ? 29 PRO H C   1 
ATOM   1741 O O   . PRO H 1 29 ? 151.870 124.355 130.315 1.00 62.30 ? 29 PRO H O   1 
ATOM   1742 C CB  . PRO H 1 29 ? 154.423 124.688 128.387 1.00 62.30 ? 29 PRO H CB  1 
ATOM   1743 C CG  . PRO H 1 29 ? 155.195 125.004 129.620 1.00 62.30 ? 29 PRO H CG  1 
ATOM   1744 C CD  . PRO H 1 29 ? 154.824 126.400 129.994 1.00 62.30 ? 29 PRO H CD  1 
ATOM   1745 N N   . THR H 1 30 ? 151.232 123.956 128.193 1.00 65.05 ? 30 THR H N   1 
ATOM   1746 C CA  . THR H 1 30 ? 150.089 123.128 128.559 1.00 65.05 ? 30 THR H CA  1 
ATOM   1747 C C   . THR H 1 30 ? 150.174 121.780 127.852 1.00 65.05 ? 30 THR H C   1 
ATOM   1748 O O   . THR H 1 30 ? 150.552 121.709 126.679 1.00 65.05 ? 30 THR H O   1 
ATOM   1749 C CB  . THR H 1 30 ? 148.767 123.825 128.209 1.00 65.05 ? 30 THR H CB  1 
ATOM   1750 O OG1 . THR H 1 30 ? 148.885 125.227 128.474 1.00 65.05 ? 30 THR H OG1 1 
ATOM   1751 C CG2 . THR H 1 30 ? 147.633 123.271 129.050 1.00 65.05 ? 30 THR H CG2 1 
ATOM   1752 N N   . ASN H 1 31 ? 149.811 120.717 128.576 1.00 66.60 ? 31 ASN H N   1 
ATOM   1753 C CA  . ASN H 1 31 ? 149.824 119.344 128.063 1.00 66.60 ? 31 ASN H CA  1 
ATOM   1754 C C   . ASN H 1 31 ? 151.179 118.980 127.457 1.00 66.60 ? 31 ASN H C   1 
ATOM   1755 O O   . ASN H 1 31 ? 151.280 118.580 126.296 1.00 66.60 ? 31 ASN H O   1 
ATOM   1756 C CB  . ASN H 1 31 ? 148.703 119.112 127.046 1.00 66.60 ? 31 ASN H CB  1 
ATOM   1757 C CG  . ASN H 1 31 ? 147.490 119.972 127.304 1.00 66.60 ? 31 ASN H CG  1 
ATOM   1758 O OD1 . ASN H 1 31 ? 147.384 121.083 126.791 1.00 66.60 ? 31 ASN H OD1 1 
ATOM   1759 N ND2 . ASN H 1 31 ? 146.562 119.462 128.105 1.00 66.60 ? 31 ASN H ND2 1 
ATOM   1760 N N   . VAL H 1 32 ? 152.233 119.110 128.258 1.00 65.77 ? 32 VAL H N   1 
ATOM   1761 C CA  . VAL H 1 32 ? 153.584 118.855 127.786 1.00 65.77 ? 32 VAL H CA  1 
ATOM   1762 C C   . VAL H 1 32 ? 154.148 117.659 128.543 1.00 65.77 ? 32 VAL H C   1 
ATOM   1763 O O   . VAL H 1 32 ? 153.521 117.113 129.452 1.00 65.77 ? 32 VAL H O   1 
ATOM   1764 C CB  . VAL H 1 32 ? 154.502 120.079 127.950 1.00 65.77 ? 32 VAL H CB  1 
ATOM   1765 C CG1 . VAL H 1 32 ? 153.830 121.318 127.382 1.00 65.77 ? 32 VAL H CG1 1 
ATOM   1766 C CG2 . VAL H 1 32 ? 154.913 120.264 129.392 1.00 65.77 ? 32 VAL H CG2 1 
ATOM   1767 N N   . GLY H 1 33 ? 155.353 117.254 128.151 1.00 66.96 ? 33 GLY H N   1 
ATOM   1768 C CA  . GLY H 1 33 ? 156.061 116.201 128.847 1.00 66.96 ? 33 GLY H CA  1 
ATOM   1769 C C   . GLY H 1 33 ? 156.960 116.754 129.929 1.00 66.96 ? 33 GLY H C   1 
ATOM   1770 O O   . GLY H 1 33 ? 156.482 117.350 130.897 1.00 66.96 ? 33 GLY H O   1 
ATOM   1771 N N   . SER H 1 34 ? 158.267 116.562 129.779 1.00 66.15 ? 34 SER H N   1 
ATOM   1772 C CA  . SER H 1 34 ? 159.242 117.091 130.730 1.00 66.15 ? 34 SER H CA  1 
ATOM   1773 C C   . SER H 1 34 ? 159.491 118.560 130.414 1.00 66.15 ? 34 SER H C   1 
ATOM   1774 O O   . SER H 1 34 ? 160.010 118.902 129.351 1.00 66.15 ? 34 SER H O   1 
ATOM   1775 C CB  . SER H 1 34 ? 160.535 116.287 130.670 1.00 66.15 ? 34 SER H CB  1 
ATOM   1776 O OG  . SER H 1 34 ? 161.497 116.801 131.574 1.00 66.15 ? 34 SER H OG  1 
ATOM   1777 N N   . ASN H 1 35 ? 159.110 119.438 131.337 1.00 62.87 ? 35 ASN H N   1 
ATOM   1778 C CA  . ASN H 1 35 ? 159.291 120.871 131.164 1.00 62.87 ? 35 ASN H CA  1 
ATOM   1779 C C   . ASN H 1 35 ? 160.362 121.392 132.113 1.00 62.87 ? 35 ASN H C   1 
ATOM   1780 O O   . ASN H 1 35 ? 160.436 120.973 133.271 1.00 62.87 ? 35 ASN H O   1 
ATOM   1781 C CB  . ASN H 1 35 ? 157.976 121.614 131.404 1.00 62.87 ? 35 ASN H CB  1 
ATOM   1782 C CG  . ASN H 1 35 ? 158.097 123.099 131.163 1.00 62.87 ? 35 ASN H CG  1 
ATOM   1783 O OD1 . ASN H 1 35 ? 158.010 123.564 130.029 1.00 62.87 ? 35 ASN H OD1 1 
ATOM   1784 N ND2 . ASN H 1 35 ? 158.308 123.854 132.231 1.00 62.87 ? 35 ASN H ND2 1 
ATOM   1785 N N   . THR H 1 36 ? 161.192 122.302 131.611 1.00 61.48 ? 36 THR H N   1 
ATOM   1786 C CA  . THR H 1 36 ? 162.257 122.885 132.410 1.00 61.48 ? 36 THR H CA  1 
ATOM   1787 C C   . THR H 1 36 ? 162.429 124.348 132.029 1.00 61.48 ? 36 THR H C   1 
ATOM   1788 O O   . THR H 1 36 ? 162.392 124.696 130.847 1.00 61.48 ? 36 THR H O   1 
ATOM   1789 C CB  . THR H 1 36 ? 163.579 122.134 132.211 1.00 61.48 ? 36 THR H CB  1 
ATOM   1790 O OG1 . THR H 1 36 ? 163.362 120.729 132.392 1.00 61.48 ? 36 THR H OG1 1 
ATOM   1791 C CG2 . THR H 1 36 ? 164.620 122.611 133.210 1.00 61.48 ? 36 THR H CG2 1 
ATOM   1792 N N   . TYR H 1 37 ? 162.614 125.197 133.035 1.00 57.79 ? 37 TYR H N   1 
ATOM   1793 C CA  . TYR H 1 37 ? 162.879 126.614 132.810 1.00 57.79 ? 37 TYR H CA  1 
ATOM   1794 C C   . TYR H 1 37 ? 164.362 126.932 132.945 1.00 57.79 ? 37 TYR H C   1 
ATOM   1795 O O   . TYR H 1 37 ? 164.749 128.098 133.028 1.00 57.79 ? 37 TYR H O   1 
ATOM   1796 C CB  . TYR H 1 37 ? 162.079 127.473 133.785 1.00 57.79 ? 37 TYR H CB  1 
ATOM   1797 C CG  . TYR H 1 37 ? 160.611 127.576 133.455 1.00 57.79 ? 37 TYR H CG  1 
ATOM   1798 C CD1 . TYR H 1 37 ? 160.146 128.554 132.591 1.00 57.79 ? 37 TYR H CD1 1 
ATOM   1799 C CD2 . TYR H 1 37 ? 159.691 126.700 134.006 1.00 57.79 ? 37 TYR H CD2 1 
ATOM   1800 C CE1 . TYR H 1 37 ? 158.808 128.656 132.287 1.00 57.79 ? 37 TYR H CE1 1 
ATOM   1801 C CE2 . TYR H 1 37 ? 158.349 126.796 133.708 1.00 57.79 ? 37 TYR H CE2 1 
ATOM   1802 C CZ  . TYR H 1 37 ? 157.914 127.776 132.848 1.00 57.79 ? 37 TYR H CZ  1 
ATOM   1803 O OH  . TYR H 1 37 ? 156.579 127.876 132.545 1.00 57.79 ? 37 TYR H OH  1 
HETATM 1804 N N   . NH2 H 1 38 ? 165.189 125.892 132.965 1.00 60.94 ? 38 NH2 H N   1 
ATOM   1805 N N   . CYS I 1 2  ? 118.932 139.455 132.242 1.00 90.80 ? 2  CYS I N   1 
ATOM   1806 C CA  . CYS I 1 2  ? 119.683 138.267 131.852 1.00 90.80 ? 2  CYS I CA  1 
ATOM   1807 C C   . CYS I 1 2  ? 119.174 137.026 132.580 1.00 90.80 ? 2  CYS I C   1 
ATOM   1808 O O   . CYS I 1 2  ? 118.888 137.072 133.775 1.00 90.80 ? 2  CYS I O   1 
ATOM   1809 C CB  . CYS I 1 2  ? 121.172 138.462 132.130 1.00 90.80 ? 2  CYS I CB  1 
ATOM   1810 S SG  . CYS I 1 2  ? 121.835 140.053 131.597 1.00 90.80 ? 2  CYS I SG  1 
ATOM   1811 N N   . ASN I 1 3  ? 119.057 135.920 131.849 1.00 93.76 ? 3  ASN I N   1 
ATOM   1812 C CA  . ASN I 1 3  ? 118.643 134.637 132.408 1.00 93.76 ? 3  ASN I CA  1 
ATOM   1813 C C   . ASN I 1 3  ? 119.771 133.632 132.206 1.00 93.76 ? 3  ASN I C   1 
ATOM   1814 O O   . ASN I 1 3  ? 120.058 133.234 131.072 1.00 93.76 ? 3  ASN I O   1 
ATOM   1815 C CB  . ASN I 1 3  ? 117.349 134.148 131.759 1.00 93.76 ? 3  ASN I CB  1 
ATOM   1816 C CG  . ASN I 1 3  ? 116.158 135.017 132.109 1.00 93.76 ? 3  ASN I CG  1 
ATOM   1817 O OD1 . ASN I 1 3  ? 116.309 136.169 132.512 1.00 93.76 ? 3  ASN I OD1 1 
ATOM   1818 N ND2 . ASN I 1 3  ? 114.961 134.465 131.958 1.00 93.76 ? 3  ASN I ND2 1 
ATOM   1819 N N   . THR I 1 4  ? 120.396 133.218 133.310 1.00 90.60 ? 4  THR I N   1 
ATOM   1820 C CA  . THR I 1 4  ? 121.481 132.231 133.306 1.00 90.60 ? 4  THR I CA  1 
ATOM   1821 C C   . THR I 1 4  ? 122.582 132.624 132.323 1.00 90.60 ? 4  THR I C   1 
ATOM   1822 O O   . THR I 1 4  ? 123.179 131.777 131.654 1.00 90.60 ? 4  THR I O   1 
ATOM   1823 C CB  . THR I 1 4  ? 120.965 130.826 132.986 1.00 90.60 ? 4  THR I CB  1 
ATOM   1824 O OG1 . THR I 1 4  ? 120.897 130.664 131.569 1.00 90.60 ? 4  THR I OG1 1 
ATOM   1825 C CG2 . THR I 1 4  ? 119.574 130.600 133.565 1.00 90.60 ? 4  THR I CG2 1 
ATOM   1826 N N   . ALA I 1 5  ? 122.860 133.922 132.237 1.00 84.35 ? 5  ALA I N   1 
ATOM   1827 C CA  . ALA I 1 5  ? 123.722 134.458 131.190 1.00 84.35 ? 5  ALA I CA  1 
ATOM   1828 C C   . ALA I 1 5  ? 124.712 135.449 131.784 1.00 84.35 ? 5  ALA I C   1 
ATOM   1829 O O   . ALA I 1 5  ? 124.307 136.438 132.396 1.00 84.35 ? 5  ALA I O   1 
ATOM   1830 C CB  . ALA I 1 5  ? 122.884 135.136 130.103 1.00 84.35 ? 5  ALA I CB  1 
ATOM   1831 N N   . THR I 1 6  ? 126.002 135.198 131.576 1.00 78.58 ? 6  THR I N   1 
ATOM   1832 C CA  . THR I 1 6  ? 127.036 136.145 131.980 1.00 78.58 ? 6  THR I CA  1 
ATOM   1833 C C   . THR I 1 6  ? 127.011 137.332 131.027 1.00 78.58 ? 6  THR I C   1 
ATOM   1834 O O   . THR I 1 6  ? 127.448 137.221 129.878 1.00 78.58 ? 6  THR I O   1 
ATOM   1835 C CB  . THR I 1 6  ? 128.404 135.472 131.981 1.00 78.58 ? 6  THR I CB  1 
ATOM   1836 O OG1 . THR I 1 6  ? 128.903 135.406 130.642 1.00 78.58 ? 6  THR I OG1 1 
ATOM   1837 C CG2 . THR I 1 6  ? 128.299 134.062 132.536 1.00 78.58 ? 6  THR I CG2 1 
ATOM   1838 N N   . CYS I 1 7  ? 126.513 138.472 131.496 1.00 81.23 ? 7  CYS I N   1 
ATOM   1839 C CA  . CYS I 1 7  ? 126.170 139.599 130.631 1.00 81.23 ? 7  CYS I CA  1 
ATOM   1840 C C   . CYS I 1 7  ? 126.875 140.870 131.086 1.00 81.23 ? 7  CYS I C   1 
ATOM   1841 O O   . CYS I 1 7  ? 126.253 141.909 131.317 1.00 81.23 ? 7  CYS I O   1 
ATOM   1842 C CB  . CYS I 1 7  ? 124.660 139.802 130.558 1.00 81.23 ? 7  CYS I CB  1 
ATOM   1843 S SG  . CYS I 1 7  ? 123.797 139.959 132.114 1.00 81.23 ? 7  CYS I SG  1 
ATOM   1844 N N   . ALA I 1 8  ? 128.196 140.784 131.248 1.00 73.82 ? 8  ALA I N   1 
ATOM   1845 C CA  . ALA I 1 8  ? 128.993 141.938 131.646 1.00 73.82 ? 8  ALA I CA  1 
ATOM   1846 C C   . ALA I 1 8  ? 128.777 143.118 130.704 1.00 73.82 ? 8  ALA I C   1 
ATOM   1847 O O   . ALA I 1 8  ? 128.788 142.964 129.483 1.00 73.82 ? 8  ALA I O   1 
ATOM   1848 C CB  . ALA I 1 8  ? 130.473 141.561 131.676 1.00 73.82 ? 8  ALA I CB  1 
ATOM   1849 N N   . THR I 1 9  ? 128.577 144.303 131.280 1.00 70.04 ? 9  THR I N   1 
ATOM   1850 C CA  . THR I 1 9  ? 128.316 145.514 130.518 1.00 70.04 ? 9  THR I CA  1 
ATOM   1851 C C   . THR I 1 9  ? 129.080 146.683 131.123 1.00 70.04 ? 9  THR I C   1 
ATOM   1852 O O   . THR I 1 9  ? 129.298 146.737 132.335 1.00 70.04 ? 9  THR I O   1 
ATOM   1853 C CB  . THR I 1 9  ? 126.816 145.840 130.492 1.00 70.04 ? 9  THR I CB  1 
ATOM   1854 O OG1 . THR I 1 9  ? 126.069 144.637 130.273 1.00 70.04 ? 9  THR I OG1 1 
ATOM   1855 C CG2 . THR I 1 9  ? 126.500 146.829 129.382 1.00 70.04 ? 9  THR I CG2 1 
ATOM   1856 N N   . GLN I 1 10 ? 129.498 147.618 130.269 1.00 63.39 ? 10 GLN I N   1 
ATOM   1857 C CA  . GLN I 1 10 ? 130.000 148.902 130.735 1.00 63.39 ? 10 GLN I CA  1 
ATOM   1858 C C   . GLN I 1 10 ? 129.442 150.011 129.858 1.00 63.39 ? 10 GLN I C   1 
ATOM   1859 O O   . GLN I 1 10 ? 129.048 149.780 128.713 1.00 63.39 ? 10 GLN I O   1 
ATOM   1860 C CB  . GLN I 1 10 ? 131.531 148.987 130.749 1.00 63.39 ? 10 GLN I CB  1 
ATOM   1861 C CG  . GLN I 1 10 ? 132.264 148.115 129.761 1.00 63.39 ? 10 GLN I CG  1 
ATOM   1862 C CD  . GLN I 1 10 ? 133.765 148.222 129.942 1.00 63.39 ? 10 GLN I CD  1 
ATOM   1863 O OE1 . GLN I 1 10 ? 134.245 149.017 130.746 1.00 63.39 ? 10 GLN I OE1 1 
ATOM   1864 N NE2 . GLN I 1 10 ? 134.513 147.430 129.189 1.00 63.39 ? 10 GLN I NE2 1 
ATOM   1865 N N   . ARG I 1 11 ? 129.398 151.218 130.416 1.00 65.50 ? 11 ARG I N   1 
ATOM   1866 C CA  . ARG I 1 11 ? 128.863 152.376 129.718 1.00 65.50 ? 11 ARG I CA  1 
ATOM   1867 C C   . ARG I 1 11 ? 129.683 153.608 130.063 1.00 65.50 ? 11 ARG I C   1 
ATOM   1868 O O   . ARG I 1 11 ? 130.027 153.829 131.228 1.00 65.50 ? 11 ARG I O   1 
ATOM   1869 C CB  . ARG I 1 11 ? 127.394 152.615 130.080 1.00 65.50 ? 11 ARG I CB  1 
ATOM   1870 C CG  . ARG I 1 11 ? 126.427 151.650 129.425 1.00 65.50 ? 11 ARG I CG  1 
ATOM   1871 C CD  . ARG I 1 11 ? 124.989 152.084 129.644 1.00 65.50 ? 11 ARG I CD  1 
ATOM   1872 N NE  . ARG I 1 11 ? 124.041 151.222 128.948 1.00 65.50 ? 11 ARG I NE  1 
ATOM   1873 C CZ  . ARG I 1 11 ? 122.732 151.427 128.909 1.00 65.50 ? 11 ARG I CZ  1 
ATOM   1874 N NH1 . ARG I 1 11 ? 122.177 152.464 129.514 1.00 65.50 ? 11 ARG I NH1 1 
ATOM   1875 N NH2 . ARG I 1 11 ? 121.961 150.570 128.246 1.00 65.50 ? 11 ARG I NH2 1 
ATOM   1876 N N   . LEU I 1 12 ? 129.994 154.404 129.045 1.00 64.37 ? 12 LEU I N   1 
ATOM   1877 C CA  . LEU I 1 12 ? 130.629 155.704 129.212 1.00 64.37 ? 12 LEU I CA  1 
ATOM   1878 C C   . LEU I 1 12 ? 129.809 156.720 128.434 1.00 64.37 ? 12 LEU I C   1 
ATOM   1879 O O   . LEU I 1 12 ? 129.509 156.498 127.257 1.00 64.37 ? 12 LEU I O   1 
ATOM   1880 C CB  . LEU I 1 12 ? 132.080 155.686 128.720 1.00 64.37 ? 12 LEU I CB  1 
ATOM   1881 C CG  . LEU I 1 12 ? 133.099 154.883 129.532 1.00 64.37 ? 12 LEU I CG  1 
ATOM   1882 C CD1 . LEU I 1 12 ? 133.105 153.424 129.120 1.00 64.37 ? 12 LEU I CD1 1 
ATOM   1883 C CD2 . LEU I 1 12 ? 134.486 155.475 129.372 1.00 64.37 ? 12 LEU I CD2 1 
ATOM   1884 N N   . ALA I 1 13 ? 129.437 157.823 129.078 1.00 70.00 ? 13 ALA I N   1 
ATOM   1885 C CA  . ALA I 1 13 ? 128.530 158.754 128.423 1.00 70.00 ? 13 ALA I CA  1 
ATOM   1886 C C   . ALA I 1 13 ? 128.704 160.156 128.984 1.00 70.00 ? 13 ALA I C   1 
ATOM   1887 O O   . ALA I 1 13 ? 129.127 160.345 130.128 1.00 70.00 ? 13 ALA I O   1 
ATOM   1888 C CB  . ALA I 1 13 ? 127.073 158.303 128.569 1.00 70.00 ? 13 ALA I CB  1 
ATOM   1889 N N   . ASN I 1 14 ? 128.368 161.137 128.144 1.00 73.26 ? 14 ASN I N   1 
ATOM   1890 C CA  . ASN I 1 14 ? 128.233 162.540 128.536 1.00 73.26 ? 14 ASN I CA  1 
ATOM   1891 C C   . ASN I 1 14 ? 129.480 163.066 129.240 1.00 73.26 ? 14 ASN I C   1 
ATOM   1892 O O   . ASN I 1 14 ? 129.403 163.765 130.251 1.00 73.26 ? 14 ASN I O   1 
ATOM   1893 C CB  . ASN I 1 14 ? 126.992 162.736 129.405 1.00 73.26 ? 14 ASN I CB  1 
ATOM   1894 C CG  . ASN I 1 14 ? 125.759 162.098 128.808 1.00 73.26 ? 14 ASN I CG  1 
ATOM   1895 O OD1 . ASN I 1 14 ? 125.210 162.584 127.818 1.00 73.26 ? 14 ASN I OD1 1 
ATOM   1896 N ND2 . ASN I 1 14 ? 125.307 161.003 129.408 1.00 73.26 ? 14 ASN I ND2 1 
ATOM   1897 N N   . PHE I 1 15 ? 130.645 162.741 128.691 1.00 71.42 ? 15 PHE I N   1 
ATOM   1898 C CA  . PHE I 1 15 ? 131.899 163.171 129.289 1.00 71.42 ? 15 PHE I CA  1 
ATOM   1899 C C   . PHE I 1 15 ? 132.740 163.931 128.271 1.00 71.42 ? 15 PHE I C   1 
ATOM   1900 O O   . PHE I 1 15 ? 132.377 164.064 127.104 1.00 71.42 ? 15 PHE I O   1 
ATOM   1901 C CB  . PHE I 1 15 ? 132.686 161.987 129.860 1.00 71.42 ? 15 PHE I CB  1 
ATOM   1902 C CG  . PHE I 1 15 ? 133.104 160.974 128.837 1.00 71.42 ? 15 PHE I CG  1 
ATOM   1903 C CD1 . PHE I 1 15 ? 132.248 159.954 128.465 1.00 71.42 ? 15 PHE I CD1 1 
ATOM   1904 C CD2 . PHE I 1 15 ? 134.365 161.025 128.268 1.00 71.42 ? 15 PHE I CD2 1 
ATOM   1905 C CE1 . PHE I 1 15 ? 132.636 159.013 127.532 1.00 71.42 ? 15 PHE I CE1 1 
ATOM   1906 C CE2 . PHE I 1 15 ? 134.759 160.090 127.336 1.00 71.42 ? 15 PHE I CE2 1 
ATOM   1907 C CZ  . PHE I 1 15 ? 133.893 159.079 126.968 1.00 71.42 ? 15 PHE I CZ  1 
ATOM   1908 N N   . LEU I 1 16 ? 133.867 164.457 128.747 1.00 72.35 ? 16 LEU I N   1 
ATOM   1909 C CA  . LEU I 1 16 ? 134.810 165.183 127.909 1.00 72.35 ? 16 LEU I CA  1 
ATOM   1910 C C   . LEU I 1 16 ? 136.218 164.889 128.399 1.00 72.35 ? 16 LEU I C   1 
ATOM   1911 O O   . LEU I 1 16 ? 136.503 165.037 129.590 1.00 72.35 ? 16 LEU I O   1 
ATOM   1912 C CB  . LEU I 1 16 ? 134.551 166.694 127.942 1.00 72.35 ? 16 LEU I CB  1 
ATOM   1913 C CG  . LEU I 1 16 ? 133.284 167.215 127.263 1.00 72.35 ? 16 LEU I CG  1 
ATOM   1914 C CD1 . LEU I 1 16 ? 132.152 167.356 128.267 1.00 72.35 ? 16 LEU I CD1 1 
ATOM   1915 C CD2 . LEU I 1 16 ? 133.559 168.540 126.571 1.00 72.35 ? 16 LEU I CD2 1 
ATOM   1916 N N   . VAL I 1 17 ? 137.088 164.474 127.488 1.00 69.22 ? 17 VAL I N   1 
ATOM   1917 C CA  . VAL I 1 17 ? 138.473 164.150 127.809 1.00 69.22 ? 17 VAL I CA  1 
ATOM   1918 C C   . VAL I 1 17 ? 139.349 165.066 126.967 1.00 69.22 ? 17 VAL I C   1 
ATOM   1919 O O   . VAL I 1 17 ? 139.249 165.080 125.737 1.00 69.22 ? 17 VAL I O   1 
ATOM   1920 C CB  . VAL I 1 17 ? 138.801 162.676 127.558 1.00 69.22 ? 17 VAL I CB  1 
ATOM   1921 C CG1 . VAL I 1 17 ? 140.266 162.409 127.844 1.00 69.22 ? 17 VAL I CG1 1 
ATOM   1922 C CG2 . VAL I 1 17 ? 137.923 161.789 128.418 1.00 69.22 ? 17 VAL I CG2 1 
ATOM   1923 N N   . HIS I 1 18 ? 140.202 165.842 127.626 1.00 73.46 ? 18 HIS I N   1 
ATOM   1924 C CA  . HIS I 1 18 ? 141.139 166.719 126.940 1.00 73.46 ? 18 HIS I CA  1 
ATOM   1925 C C   . HIS I 1 18 ? 142.558 166.292 127.294 1.00 73.46 ? 18 HIS I C   1 
ATOM   1926 O O   . HIS I 1 18 ? 142.900 166.172 128.474 1.00 73.46 ? 18 HIS I O   1 
ATOM   1927 C CB  . HIS I 1 18 ? 140.894 168.175 127.330 1.00 73.46 ? 18 HIS I CB  1 
ATOM   1928 C CG  . HIS I 1 18 ? 141.624 169.162 126.473 1.00 73.46 ? 18 HIS I CG  1 
ATOM   1929 N ND1 . HIS I 1 18 ? 142.997 169.267 126.463 1.00 73.46 ? 18 HIS I ND1 1 
ATOM   1930 C CD2 . HIS I 1 18 ? 141.168 170.090 125.599 1.00 73.46 ? 18 HIS I CD2 1 
ATOM   1931 C CE1 . HIS I 1 18 ? 143.357 170.217 125.619 1.00 73.46 ? 18 HIS I CE1 1 
ATOM   1932 N NE2 . HIS I 1 18 ? 142.266 170.732 125.081 1.00 73.46 ? 18 HIS I NE2 1 
ATOM   1933 N N   . SER I 1 19 ? 143.381 166.064 126.274 1.00 68.99 ? 19 SER I N   1 
ATOM   1934 C CA  . SER I 1 19 ? 144.753 165.628 126.469 1.00 68.99 ? 19 SER I CA  1 
ATOM   1935 C C   . SER I 1 19 ? 145.693 166.506 125.660 1.00 68.99 ? 19 SER I C   1 
ATOM   1936 O O   . SER I 1 19 ? 145.323 167.038 124.610 1.00 68.99 ? 19 SER I O   1 
ATOM   1937 C CB  . SER I 1 19 ? 144.939 164.163 126.067 1.00 68.99 ? 19 SER I CB  1 
ATOM   1938 O OG  . SER I 1 19 ? 146.285 163.759 126.245 1.00 68.99 ? 19 SER I OG  1 
ATOM   1939 N N   . SER I 1 20 ? 146.916 166.657 126.163 1.00 71.47 ? 20 SER I N   1 
ATOM   1940 C CA  . SER I 1 20 ? 147.934 167.467 125.510 1.00 71.47 ? 20 SER I CA  1 
ATOM   1941 C C   . SER I 1 20 ? 149.117 166.639 125.039 1.00 71.47 ? 20 SER I C   1 
ATOM   1942 O O   . SER I 1 20 ? 149.581 166.815 123.907 1.00 71.47 ? 20 SER I O   1 
ATOM   1943 C CB  . SER I 1 20 ? 148.409 168.579 126.460 1.00 71.47 ? 20 SER I CB  1 
ATOM   1944 O OG  . SER I 1 20 ? 147.331 169.419 126.831 1.00 71.47 ? 20 SER I OG  1 
ATOM   1945 N N   . ASN I 1 21 ? 149.632 165.755 125.884 1.00 71.76 ? 21 ASN I N   1 
ATOM   1946 C CA  . ASN I 1 21 ? 150.659 164.798 125.500 1.00 71.76 ? 21 ASN I CA  1 
ATOM   1947 C C   . ASN I 1 21 ? 150.314 163.463 126.137 1.00 71.76 ? 21 ASN I C   1 
ATOM   1948 O O   . ASN I 1 21 ? 149.873 163.423 127.289 1.00 71.76 ? 21 ASN I O   1 
ATOM   1949 C CB  . ASN I 1 21 ? 152.049 165.258 125.940 1.00 71.76 ? 21 ASN I CB  1 
ATOM   1950 C CG  . ASN I 1 21 ? 153.154 164.381 125.391 1.00 71.76 ? 21 ASN I CG  1 
ATOM   1951 O OD1 . ASN I 1 21 ? 153.531 163.380 126.001 1.00 71.76 ? 21 ASN I OD1 1 
ATOM   1952 N ND2 . ASN I 1 21 ? 153.689 164.761 124.238 1.00 71.76 ? 21 ASN I ND2 1 
ATOM   1953 N N   . ASN I 1 22 ? 150.507 162.374 125.396 1.00 73.01 ? 22 ASN I N   1 
ATOM   1954 C CA  . ASN I 1 22 ? 150.137 161.063 125.902 1.00 73.01 ? 22 ASN I CA  1 
ATOM   1955 C C   . ASN I 1 22 ? 151.017 159.992 125.279 1.00 73.01 ? 22 ASN I C   1 
ATOM   1956 O O   . ASN I 1 22 ? 151.310 160.027 124.082 1.00 73.01 ? 22 ASN I O   1 
ATOM   1957 C CB  . ASN I 1 22 ? 148.665 160.751 125.629 1.00 73.01 ? 22 ASN I CB  1 
ATOM   1958 C CG  . ASN I 1 22 ? 148.317 159.314 125.932 1.00 73.01 ? 22 ASN I CG  1 
ATOM   1959 O OD1 . ASN I 1 22 ? 148.096 158.946 127.085 1.00 73.01 ? 22 ASN I OD1 1 
ATOM   1960 N ND2 . ASN I 1 22 ? 148.271 158.485 124.898 1.00 73.01 ? 22 ASN I ND2 1 
ATOM   1961 N N   . PHE I 1 23 ? 151.428 159.034 126.107 1.00 75.52 ? 23 PHE I N   1 
ATOM   1962 C CA  . PHE I 1 23 ? 152.218 157.895 125.657 1.00 75.52 ? 23 PHE I CA  1 
ATOM   1963 C C   . PHE I 1 23 ? 151.530 156.553 125.842 1.00 75.52 ? 23 PHE I C   1 
ATOM   1964 O O   . PHE I 1 23 ? 152.088 155.536 125.416 1.00 75.52 ? 23 PHE I O   1 
ATOM   1965 C CB  . PHE I 1 23 ? 153.572 157.854 126.384 1.00 75.52 ? 23 PHE I CB  1 
ATOM   1966 C CG  . PHE I 1 23 ? 154.622 158.745 125.778 1.00 75.52 ? 23 PHE I CG  1 
ATOM   1967 C CD1 . PHE I 1 23 ? 154.269 159.876 125.066 1.00 75.52 ? 23 PHE I CD1 1 
ATOM   1968 C CD2 . PHE I 1 23 ? 155.965 158.448 125.929 1.00 75.52 ? 23 PHE I CD2 1 
ATOM   1969 C CE1 . PHE I 1 23 ? 155.231 160.693 124.513 1.00 75.52 ? 23 PHE I CE1 1 
ATOM   1970 C CE2 . PHE I 1 23 ? 156.933 159.263 125.379 1.00 75.52 ? 23 PHE I CE2 1 
ATOM   1971 C CZ  . PHE I 1 23 ? 156.565 160.387 124.670 1.00 75.52 ? 23 PHE I CZ  1 
ATOM   1972 N N   . GLY I 1 24 ? 150.358 156.507 126.470 1.00 76.04 ? 24 GLY I N   1 
ATOM   1973 C CA  . GLY I 1 24 ? 149.635 155.264 126.658 1.00 76.04 ? 24 GLY I CA  1 
ATOM   1974 C C   . GLY I 1 24 ? 148.164 155.394 126.321 1.00 76.04 ? 24 GLY I C   1 
ATOM   1975 O O   . GLY I 1 24 ? 147.750 156.387 125.718 1.00 76.04 ? 24 GLY I O   1 
ATOM   1976 N N   . ALA I 1 25 ? 147.367 154.400 126.698 1.00 73.14 ? 25 ALA I N   1 
ATOM   1977 C CA  . ALA I 1 25 ? 145.932 154.464 126.462 1.00 73.14 ? 25 ALA I CA  1 
ATOM   1978 C C   . ALA I 1 25 ? 145.303 155.563 127.308 1.00 73.14 ? 25 ALA I C   1 
ATOM   1979 O O   . ALA I 1 25 ? 145.805 155.911 128.378 1.00 73.14 ? 25 ALA I O   1 
ATOM   1980 C CB  . ALA I 1 25 ? 145.278 153.121 126.779 1.00 73.14 ? 25 ALA I CB  1 
ATOM   1981 N N   . ILE I 1 26 ? 144.206 156.135 126.812 1.00 73.31 ? 26 ILE I N   1 
ATOM   1982 C CA  . ILE I 1 26 ? 143.463 157.078 127.640 1.00 73.31 ? 26 ILE I CA  1 
ATOM   1983 C C   . ILE I 1 26 ? 142.016 156.626 127.760 1.00 73.31 ? 26 ILE I C   1 
ATOM   1984 O O   . ILE I 1 26 ? 141.348 156.926 128.753 1.00 73.31 ? 26 ILE I O   1 
ATOM   1985 C CB  . ILE I 1 26 ? 143.547 158.523 127.110 1.00 73.31 ? 26 ILE I CB  1 
ATOM   1986 C CG1 . ILE I 1 26 ? 142.547 158.761 125.984 1.00 73.31 ? 26 ILE I CG1 1 
ATOM   1987 C CG2 . ILE I 1 26 ? 144.953 158.850 126.642 1.00 73.31 ? 26 ILE I CG2 1 
ATOM   1988 C CD1 . ILE I 1 26 ? 142.378 160.218 125.626 1.00 73.31 ? 26 ILE I CD1 1 
ATOM   1989 N N   . LEU I 1 27 ? 141.513 155.899 126.761 1.00 69.27 ? 27 LEU I N   1 
ATOM   1990 C CA  . LEU I 1 27 ? 140.192 155.278 126.892 1.00 69.27 ? 27 LEU I CA  1 
ATOM   1991 C C   . LEU I 1 27 ? 140.250 153.922 126.186 1.00 69.27 ? 27 LEU I C   1 
ATOM   1992 O O   . LEU I 1 27 ? 139.950 153.816 124.997 1.00 69.27 ? 27 LEU I O   1 
ATOM   1993 C CB  . LEU I 1 27 ? 139.086 156.153 126.318 1.00 69.27 ? 27 LEU I CB  1 
ATOM   1994 C CG  . LEU I 1 27 ? 138.404 157.174 127.232 1.00 69.27 ? 27 LEU I CG  1 
ATOM   1995 C CD1 . LEU I 1 27 ? 139.115 158.508 127.175 1.00 69.27 ? 27 LEU I CD1 1 
ATOM   1996 C CD2 . LEU I 1 27 ? 136.944 157.329 126.861 1.00 69.27 ? 27 LEU I CD2 1 
ATOM   1997 N N   . SER I 1 28 ? 140.612 152.889 126.938 1.00 69.58 ? 28 SER I N   1 
ATOM   1998 C CA  . SER I 1 28 ? 140.629 151.519 126.428 1.00 69.58 ? 28 SER I CA  1 
ATOM   1999 C C   . SER I 1 28 ? 140.022 150.586 127.464 1.00 69.58 ? 28 SER I C   1 
ATOM   2000 O O   . SER I 1 28 ? 140.709 149.739 128.044 1.00 69.58 ? 28 SER I O   1 
ATOM   2001 C CB  . SER I 1 28 ? 142.051 151.094 126.064 1.00 69.58 ? 28 SER I CB  1 
ATOM   2002 O OG  . SER I 1 28 ? 142.658 152.054 125.223 1.00 69.58 ? 28 SER I OG  1 
ATOM   2003 N N   . PRO I 1 29 ? 138.723 150.717 127.728 1.00 65.34 ? 29 PRO I N   1 
ATOM   2004 C CA  . PRO I 1 29 ? 138.077 149.787 128.655 1.00 65.34 ? 29 PRO I CA  1 
ATOM   2005 C C   . PRO I 1 29 ? 138.050 148.381 128.081 1.00 65.34 ? 29 PRO I C   1 
ATOM   2006 O O   . PRO I 1 29 ? 137.972 148.190 126.866 1.00 65.34 ? 29 PRO I O   1 
ATOM   2007 C CB  . PRO I 1 29 ? 136.666 150.362 128.814 1.00 65.34 ? 29 PRO I CB  1 
ATOM   2008 C CG  . PRO I 1 29 ? 136.441 151.136 127.580 1.00 65.34 ? 29 PRO I CG  1 
ATOM   2009 C CD  . PRO I 1 29 ? 137.766 151.691 127.173 1.00 65.34 ? 29 PRO I CD  1 
ATOM   2010 N N   . THR I 1 30 ? 138.125 147.395 128.967 1.00 65.63 ? 30 THR I N   1 
ATOM   2011 C CA  . THR I 1 30 ? 138.115 145.991 128.584 1.00 65.63 ? 30 THR I CA  1 
ATOM   2012 C C   . THR I 1 30 ? 136.851 145.340 129.120 1.00 65.63 ? 30 THR I C   1 
ATOM   2013 O O   . THR I 1 30 ? 136.564 145.429 130.317 1.00 65.63 ? 30 THR I O   1 
ATOM   2014 C CB  . THR I 1 30 ? 139.351 145.261 129.111 1.00 65.63 ? 30 THR I CB  1 
ATOM   2015 O OG1 . THR I 1 30 ? 140.533 145.890 128.603 1.00 65.63 ? 30 THR I OG1 1 
ATOM   2016 C CG2 . THR I 1 30 ? 139.333 143.806 128.682 1.00 65.63 ? 30 THR I CG2 1 
ATOM   2017 N N   . ASN I 1 31 ? 136.100 144.690 128.235 1.00 62.46 ? 31 ASN I N   1 
ATOM   2018 C CA  . ASN I 1 31 ? 134.876 143.995 128.605 1.00 62.46 ? 31 ASN I CA  1 
ATOM   2019 C C   . ASN I 1 31 ? 134.994 142.548 128.160 1.00 62.46 ? 31 ASN I C   1 
ATOM   2020 O O   . ASN I 1 31 ? 135.182 142.278 126.970 1.00 62.46 ? 31 ASN I O   1 
ATOM   2021 C CB  . ASN I 1 31 ? 133.651 144.652 127.968 1.00 62.46 ? 31 ASN I CB  1 
ATOM   2022 C CG  . ASN I 1 31 ? 132.356 144.132 128.535 1.00 62.46 ? 31 ASN I CG  1 
ATOM   2023 O OD1 . ASN I 1 31 ? 132.340 143.467 129.569 1.00 62.46 ? 31 ASN I OD1 1 
ATOM   2024 N ND2 . ASN I 1 31 ? 131.255 144.436 127.866 1.00 62.46 ? 31 ASN I ND2 1 
ATOM   2025 N N   . VAL I 1 32 ? 134.889 141.622 129.108 1.00 60.49 ? 32 VAL I N   1 
ATOM   2026 C CA  . VAL I 1 32 ? 134.972 140.197 128.826 1.00 60.49 ? 32 VAL I CA  1 
ATOM   2027 C C   . VAL I 1 32 ? 133.754 139.520 129.432 1.00 60.49 ? 32 VAL I C   1 
ATOM   2028 O O   . VAL I 1 32 ? 133.532 139.605 130.643 1.00 60.49 ? 32 VAL I O   1 
ATOM   2029 C CB  . VAL I 1 32 ? 136.269 139.580 129.378 1.00 60.49 ? 32 VAL I CB  1 
ATOM   2030 C CG1 . VAL I 1 32 ? 136.208 138.065 129.299 1.00 60.49 ? 32 VAL I CG1 1 
ATOM   2031 C CG2 . VAL I 1 32 ? 137.470 140.107 128.617 1.00 60.49 ? 32 VAL I CG2 1 
ATOM   2032 N N   . GLY I 1 33 ? 132.965 138.856 128.589 1.00 61.00 ? 33 GLY I N   1 
ATOM   2033 C CA  . GLY I 1 33 ? 131.793 138.157 129.089 1.00 61.00 ? 33 GLY I CA  1 
ATOM   2034 C C   . GLY I 1 33 ? 132.150 136.986 129.983 1.00 61.00 ? 33 GLY I C   1 
ATOM   2035 O O   . GLY I 1 33 ? 131.520 136.772 131.021 1.00 61.00 ? 33 GLY I O   1 
ATOM   2036 N N   . SER I 1 34 ? 133.156 136.210 129.594 1.00 59.91 ? 34 SER I N   1 
ATOM   2037 C CA  . SER I 1 34 ? 133.587 135.061 130.375 1.00 59.91 ? 34 SER I CA  1 
ATOM   2038 C C   . SER I 1 34 ? 134.971 134.640 129.912 1.00 59.91 ? 34 SER I C   1 
ATOM   2039 O O   . SER I 1 34 ? 135.322 134.796 128.742 1.00 59.91 ? 34 SER I O   1 
ATOM   2040 C CB  . SER I 1 34 ? 132.604 133.893 130.246 1.00 59.91 ? 34 SER I CB  1 
ATOM   2041 O OG  . SER I 1 34 ? 132.559 133.420 128.913 1.00 59.91 ? 34 SER I OG  1 
ATOM   2042 N N   . ASN I 1 35 ? 135.751 134.100 130.847 1.00 64.80 ? 35 ASN I N   1 
ATOM   2043 C CA  . ASN I 1 35 ? 137.097 133.602 130.571 1.00 64.80 ? 35 ASN I CA  1 
ATOM   2044 C C   . ASN I 1 35 ? 137.201 132.193 131.145 1.00 64.80 ? 35 ASN I C   1 
ATOM   2045 O O   . ASN I 1 35 ? 137.222 132.009 132.364 1.00 64.80 ? 35 ASN I O   1 
ATOM   2046 C CB  . ASN I 1 35 ? 138.159 134.517 131.160 1.00 64.80 ? 35 ASN I CB  1 
ATOM   2047 C CG  . ASN I 1 35 ? 139.544 134.196 130.650 1.00 64.80 ? 35 ASN I CG  1 
ATOM   2048 O OD1 . ASN I 1 35 ? 139.743 133.225 129.925 1.00 64.80 ? 35 ASN I OD1 1 
ATOM   2049 N ND2 . ASN I 1 35 ? 140.518 134.998 131.049 1.00 64.80 ? 35 ASN I ND2 1 
ATOM   2050 N N   . THR I 1 36 ? 137.267 131.200 130.266 1.00 67.27 ? 36 THR I N   1 
ATOM   2051 C CA  . THR I 1 36 ? 137.417 129.810 130.679 1.00 67.27 ? 36 THR I CA  1 
ATOM   2052 C C   . THR I 1 36 ? 138.862 129.386 130.455 1.00 67.27 ? 36 THR I C   1 
ATOM   2053 O O   . THR I 1 36 ? 139.403 129.548 129.357 1.00 67.27 ? 36 THR I O   1 
ATOM   2054 C CB  . THR I 1 36 ? 136.453 128.910 129.912 1.00 67.27 ? 36 THR I CB  1 
ATOM   2055 O OG1 . THR I 1 36 ? 135.105 129.242 130.267 1.00 67.27 ? 36 THR I OG1 1 
ATOM   2056 C CG2 . THR I 1 36 ? 136.711 127.451 130.247 1.00 67.27 ? 36 THR I CG2 1 
ATOM   2057 N N   . TYR I 1 37 ? 139.489 128.857 131.499 1.00 68.49 ? 37 TYR I N   1 
ATOM   2058 C CA  . TYR I 1 37 ? 140.832 128.304 131.412 1.00 68.49 ? 37 TYR I CA  1 
ATOM   2059 C C   . TYR I 1 37 ? 140.857 126.914 132.033 1.00 68.49 ? 37 TYR I C   1 
ATOM   2060 O O   . TYR I 1 37 ? 141.689 126.622 132.893 1.00 68.49 ? 37 TYR I O   1 
ATOM   2061 C CB  . TYR I 1 37 ? 141.840 129.223 132.103 1.00 68.49 ? 37 TYR I CB  1 
ATOM   2062 C CG  . TYR I 1 37 ? 143.284 128.991 131.712 1.00 68.49 ? 37 TYR I CG  1 
ATOM   2063 C CD1 . TYR I 1 37 ? 143.639 127.965 130.851 1.00 68.49 ? 37 TYR I CD1 1 
ATOM   2064 C CD2 . TYR I 1 37 ? 144.291 129.791 132.222 1.00 68.49 ? 37 TYR I CD2 1 
ATOM   2065 C CE1 . TYR I 1 37 ? 144.956 127.747 130.505 1.00 68.49 ? 37 TYR I CE1 1 
ATOM   2066 C CE2 . TYR I 1 37 ? 145.609 129.583 131.880 1.00 68.49 ? 37 TYR I CE2 1 
ATOM   2067 C CZ  . TYR I 1 37 ? 145.937 128.560 131.022 1.00 68.49 ? 37 TYR I CZ  1 
ATOM   2068 O OH  . TYR I 1 37 ? 147.252 128.350 130.679 1.00 68.49 ? 37 TYR I OH  1 
HETATM 2069 N N   . NH2 I 1 38 ? 139.938 126.061 131.596 1.00 69.60 ? 38 NH2 I N   1 
ATOM   2070 N N   . ALA J 1 13 ? 169.412 132.929 127.773 1.00 44.34 ? 13 ALA J N   1 
ATOM   2071 C CA  . ALA J 1 13 ? 168.213 133.191 126.988 1.00 44.34 ? 13 ALA J CA  1 
ATOM   2072 C C   . ALA J 1 13 ? 167.283 134.146 127.722 1.00 44.34 ? 13 ALA J C   1 
ATOM   2073 O O   . ALA J 1 13 ? 166.510 133.733 128.584 1.00 44.34 ? 13 ALA J O   1 
ATOM   2074 C CB  . ALA J 1 13 ? 167.495 131.894 126.672 1.00 44.34 ? 13 ALA J CB  1 
ATOM   2075 N N   . ASN J 1 14 ? 167.355 135.426 127.374 1.00 45.28 ? 14 ASN J N   1 
ATOM   2076 C CA  . ASN J 1 14 ? 166.548 136.439 128.037 1.00 45.28 ? 14 ASN J CA  1 
ATOM   2077 C C   . ASN J 1 14 ? 165.165 136.519 127.405 1.00 45.28 ? 14 ASN J C   1 
ATOM   2078 O O   . ASN J 1 14 ? 165.022 136.475 126.180 1.00 45.28 ? 14 ASN J O   1 
ATOM   2079 C CB  . ASN J 1 14 ? 167.232 137.801 127.964 1.00 45.28 ? 14 ASN J CB  1 
ATOM   2080 C CG  . ASN J 1 14 ? 168.644 137.767 128.505 1.00 45.28 ? 14 ASN J CG  1 
ATOM   2081 O OD1 . ASN J 1 14 ? 169.273 136.711 128.566 1.00 45.28 ? 14 ASN J OD1 1 
ATOM   2082 N ND2 . ASN J 1 14 ? 169.150 138.926 128.907 1.00 45.28 ? 14 ASN J ND2 1 
ATOM   2083 N N   . PHE J 1 15 ? 164.147 136.635 128.250 1.00 44.94 ? 15 PHE J N   1 
ATOM   2084 C CA  . PHE J 1 15 ? 162.760 136.726 127.815 1.00 44.94 ? 15 PHE J CA  1 
ATOM   2085 C C   . PHE J 1 15 ? 162.168 138.026 128.329 1.00 44.94 ? 15 PHE J C   1 
ATOM   2086 O O   . PHE J 1 15 ? 162.319 138.357 129.510 1.00 44.94 ? 15 PHE J O   1 
ATOM   2087 C CB  . PHE J 1 15 ? 161.946 135.538 128.329 1.00 44.94 ? 15 PHE J CB  1 
ATOM   2088 C CG  . PHE J 1 15 ? 162.335 134.229 127.714 1.00 44.94 ? 15 PHE J CG  1 
ATOM   2089 C CD1 . PHE J 1 15 ? 163.417 133.519 128.195 1.00 44.94 ? 15 PHE J CD1 1 
ATOM   2090 C CD2 . PHE J 1 15 ? 161.606 133.698 126.670 1.00 44.94 ? 15 PHE J CD2 1 
ATOM   2091 C CE1 . PHE J 1 15 ? 163.776 132.312 127.637 1.00 44.94 ? 15 PHE J CE1 1 
ATOM   2092 C CE2 . PHE J 1 15 ? 161.958 132.489 126.109 1.00 44.94 ? 15 PHE J CE2 1 
ATOM   2093 C CZ  . PHE J 1 15 ? 163.044 131.798 126.595 1.00 44.94 ? 15 PHE J CZ  1 
ATOM   2094 N N   . LEU J 1 16 ? 161.504 138.768 127.447 1.00 42.74 ? 16 LEU J N   1 
ATOM   2095 C CA  . LEU J 1 16 ? 160.839 140.006 127.824 1.00 42.74 ? 16 LEU J CA  1 
ATOM   2096 C C   . LEU J 1 16 ? 159.457 140.034 127.193 1.00 42.74 ? 16 LEU J C   1 
ATOM   2097 O O   . LEU J 1 16 ? 159.323 139.828 125.985 1.00 42.74 ? 16 LEU J O   1 
ATOM   2098 C CB  . LEU J 1 16 ? 161.642 141.236 127.387 1.00 42.74 ? 16 LEU J CB  1 
ATOM   2099 C CG  . LEU J 1 16 ? 162.921 141.552 128.161 1.00 42.74 ? 16 LEU J CG  1 
ATOM   2100 C CD1 . LEU J 1 16 ? 164.119 140.836 127.560 1.00 42.74 ? 16 LEU J CD1 1 
ATOM   2101 C CD2 . LEU J 1 16 ? 163.154 143.052 128.195 1.00 42.74 ? 16 LEU J CD2 1 
ATOM   2102 N N   . VAL J 1 17 ? 158.438 140.287 128.007 1.00 39.99 ? 17 VAL J N   1 
ATOM   2103 C CA  . VAL J 1 17 ? 157.064 140.380 127.532 1.00 39.99 ? 17 VAL J CA  1 
ATOM   2104 C C   . VAL J 1 17 ? 156.457 141.661 128.085 1.00 39.99 ? 17 VAL J C   1 
ATOM   2105 O O   . VAL J 1 17 ? 156.506 141.899 129.297 1.00 39.99 ? 17 VAL J O   1 
ATOM   2106 C CB  . VAL J 1 17 ? 156.224 139.163 127.946 1.00 39.99 ? 17 VAL J CB  1 
ATOM   2107 C CG1 . VAL J 1 17 ? 154.768 139.379 127.579 1.00 39.99 ? 17 VAL J CG1 1 
ATOM   2108 C CG2 . VAL J 1 17 ? 156.758 137.903 127.289 1.00 39.99 ? 17 VAL J CG2 1 
ATOM   2109 N N   . HIS J 1 18 ? 155.895 142.480 127.205 1.00 41.68 ? 18 HIS J N   1 
ATOM   2110 C CA  . HIS J 1 18 ? 155.104 143.644 127.590 1.00 41.68 ? 18 HIS J CA  1 
ATOM   2111 C C   . HIS J 1 18 ? 153.733 143.452 126.956 1.00 41.68 ? 18 HIS J C   1 
ATOM   2112 O O   . HIS J 1 18 ? 153.465 143.955 125.864 1.00 41.68 ? 18 HIS J O   1 
ATOM   2113 C CB  . HIS J 1 18 ? 155.749 144.950 127.141 1.00 41.68 ? 18 HIS J CB  1 
ATOM   2114 C CG  . HIS J 1 18 ? 156.998 145.298 127.888 1.00 41.68 ? 18 HIS J CG  1 
ATOM   2115 N ND1 . HIS J 1 18 ? 158.141 144.530 127.824 1.00 41.68 ? 18 HIS J ND1 1 
ATOM   2116 C CD2 . HIS J 1 18 ? 157.282 146.331 128.715 1.00 41.68 ? 18 HIS J CD2 1 
ATOM   2117 C CE1 . HIS J 1 18 ? 159.077 145.078 128.579 1.00 41.68 ? 18 HIS J CE1 1 
ATOM   2118 N NE2 . HIS J 1 18 ? 158.582 146.173 129.131 1.00 41.68 ? 18 HIS J NE2 1 
ATOM   2119 N N   . SER J 1 19 ? 152.865 142.725 127.648 1.00 42.70 ? 19 SER J N   1 
ATOM   2120 C CA  . SER J 1 19 ? 151.552 142.375 127.129 1.00 42.70 ? 19 SER J CA  1 
ATOM   2121 C C   . SER J 1 19 ? 150.536 143.390 127.633 1.00 42.70 ? 19 SER J C   1 
ATOM   2122 O O   . SER J 1 19 ? 150.468 143.662 128.836 1.00 42.70 ? 19 SER J O   1 
ATOM   2123 C CB  . SER J 1 19 ? 151.164 140.960 127.552 1.00 42.70 ? 19 SER J CB  1 
ATOM   2124 O OG  . SER J 1 19 ? 149.887 140.615 127.051 1.00 42.70 ? 19 SER J OG  1 
ATOM   2125 N N   . SER J 1 20 ? 149.754 143.951 126.714 1.00 46.73 ? 20 SER J N   1 
ATOM   2126 C CA  . SER J 1 20 ? 148.737 144.919 127.099 1.00 46.73 ? 20 SER J CA  1 
ATOM   2127 C C   . SER J 1 20 ? 147.410 144.234 127.394 1.00 46.73 ? 20 SER J C   1 
ATOM   2128 O O   . SER J 1 20 ? 146.802 144.464 128.444 1.00 46.73 ? 20 SER J O   1 
ATOM   2129 C CB  . SER J 1 20 ? 148.567 145.971 126.002 1.00 46.73 ? 20 SER J CB  1 
ATOM   2130 O OG  . SER J 1 20 ? 147.550 146.901 126.333 1.00 46.73 ? 20 SER J OG  1 
ATOM   2131 N N   . ASN J 1 21 ? 146.939 143.396 126.474 1.00 47.90 ? 21 ASN J N   1 
ATOM   2132 C CA  . ASN J 1 21 ? 145.670 142.697 126.672 1.00 47.90 ? 21 ASN J CA  1 
ATOM   2133 C C   . ASN J 1 21 ? 145.774 141.350 125.955 1.00 47.90 ? 21 ASN J C   1 
ATOM   2134 O O   . ASN J 1 21 ? 145.489 141.245 124.761 1.00 47.90 ? 21 ASN J O   1 
ATOM   2135 C CB  . ASN J 1 21 ? 144.505 143.529 126.157 1.00 47.90 ? 21 ASN J CB  1 
ATOM   2136 C CG  . ASN J 1 21 ? 143.204 143.182 126.829 1.00 47.90 ? 21 ASN J CG  1 
ATOM   2137 O OD1 . ASN J 1 21 ? 143.065 142.115 127.422 1.00 47.90 ? 21 ASN J OD1 1 
ATOM   2138 N ND2 . ASN J 1 21 ? 142.238 144.088 126.751 1.00 47.90 ? 21 ASN J ND2 1 
ATOM   2139 N N   . ASN J 1 22 ? 146.162 140.325 126.704 1.00 48.43 ? 22 ASN J N   1 
ATOM   2140 C CA  . ASN J 1 22 ? 146.399 139.000 126.156 1.00 48.43 ? 22 ASN J CA  1 
ATOM   2141 C C   . ASN J 1 22 ? 145.164 138.127 126.317 1.00 48.43 ? 22 ASN J C   1 
ATOM   2142 O O   . ASN J 1 22 ? 144.520 138.120 127.368 1.00 48.43 ? 22 ASN J O   1 
ATOM   2143 C CB  . ASN J 1 22 ? 147.593 138.336 126.844 1.00 48.43 ? 22 ASN J CB  1 
ATOM   2144 C CG  . ASN J 1 22 ? 147.937 136.989 126.247 1.00 48.43 ? 22 ASN J CG  1 
ATOM   2145 O OD1 . ASN J 1 22 ? 147.379 136.581 125.230 1.00 48.43 ? 22 ASN J OD1 1 
ATOM   2146 N ND2 . ASN J 1 22 ? 148.849 136.278 126.893 1.00 48.43 ? 22 ASN J ND2 1 
ATOM   2147 N N   . PHE J 1 23 ? 144.843 137.382 125.260 1.00 47.15 ? 23 PHE J N   1 
ATOM   2148 C CA  . PHE J 1 23 ? 143.767 136.406 125.296 1.00 47.15 ? 23 PHE J CA  1 
ATOM   2149 C C   . PHE J 1 23 ? 144.211 135.028 124.830 1.00 47.15 ? 23 PHE J C   1 
ATOM   2150 O O   . PHE J 1 23 ? 143.401 134.096 124.848 1.00 47.15 ? 23 PHE J O   1 
ATOM   2151 C CB  . PHE J 1 23 ? 142.582 136.868 124.436 1.00 47.15 ? 23 PHE J CB  1 
ATOM   2152 C CG  . PHE J 1 23 ? 141.891 138.091 124.959 1.00 47.15 ? 23 PHE J CG  1 
ATOM   2153 C CD1 . PHE J 1 23 ? 142.306 139.352 124.575 1.00 47.15 ? 23 PHE J CD1 1 
ATOM   2154 C CD2 . PHE J 1 23 ? 140.833 137.981 125.836 1.00 47.15 ? 23 PHE J CD2 1 
ATOM   2155 C CE1 . PHE J 1 23 ? 141.675 140.476 125.056 1.00 47.15 ? 23 PHE J CE1 1 
ATOM   2156 C CE2 . PHE J 1 23 ? 140.196 139.104 126.317 1.00 47.15 ? 23 PHE J CE2 1 
ATOM   2157 C CZ  . PHE J 1 23 ? 140.619 140.353 125.927 1.00 47.15 ? 23 PHE J CZ  1 
ATOM   2158 N N   . GLY J 1 24 ? 145.463 134.872 124.414 1.00 48.77 ? 24 GLY J N   1 
ATOM   2159 C CA  . GLY J 1 24 ? 145.967 133.592 123.962 1.00 48.77 ? 24 GLY J CA  1 
ATOM   2160 C C   . GLY J 1 24 ? 147.325 133.264 124.545 1.00 48.77 ? 24 GLY J C   1 
ATOM   2161 O O   . GLY J 1 24 ? 147.645 133.680 125.661 1.00 48.77 ? 24 GLY J O   1 
ATOM   2162 N N   . ALA J 1 25 ? 148.131 132.516 123.801 1.00 52.11 ? 25 ALA J N   1 
ATOM   2163 C CA  . ALA J 1 25 ? 149.454 132.140 124.275 1.00 52.11 ? 25 ALA J CA  1 
ATOM   2164 C C   . ALA J 1 25 ? 150.486 133.187 123.875 1.00 52.11 ? 25 ALA J C   1 
ATOM   2165 O O   . ALA J 1 25 ? 150.301 133.941 122.917 1.00 52.11 ? 25 ALA J O   1 
ATOM   2166 C CB  . ALA J 1 25 ? 149.850 130.776 123.716 1.00 52.11 ? 25 ALA J CB  1 
ATOM   2167 N N   . ILE J 1 26 ? 151.583 133.236 124.627 1.00 52.02 ? 26 ILE J N   1 
ATOM   2168 C CA  . ILE J 1 26 ? 152.683 134.139 124.307 1.00 52.02 ? 26 ILE J CA  1 
ATOM   2169 C C   . ILE J 1 26 ? 153.959 133.334 124.118 1.00 52.02 ? 26 ILE J C   1 
ATOM   2170 O O   . ILE J 1 26 ? 154.540 133.318 123.029 1.00 52.02 ? 26 ILE J O   1 
ATOM   2171 C CB  . ILE J 1 26 ? 152.864 135.211 125.394 1.00 52.02 ? 26 ILE J CB  1 
ATOM   2172 C CG1 . ILE J 1 26 ? 151.667 136.158 125.409 1.00 52.02 ? 26 ILE J CG1 1 
ATOM   2173 C CG2 . ILE J 1 26 ? 154.139 135.992 125.159 1.00 52.02 ? 26 ILE J CG2 1 
ATOM   2174 C CD1 . ILE J 1 26 ? 151.654 137.141 124.270 1.00 52.02 ? 26 ILE J CD1 1 
ATOM   2175 N N   . LEU J 1 27 ? 154.399 132.659 125.171 1.00 55.33 ? 27 LEU J N   1 
ATOM   2176 C CA  . LEU J 1 27 ? 155.595 131.823 125.159 1.00 55.33 ? 27 LEU J CA  1 
ATOM   2177 C C   . LEU J 1 27 ? 155.279 130.464 125.766 1.00 55.33 ? 27 LEU J C   1 
ATOM   2178 O O   . LEU J 1 27 ? 156.055 129.901 126.542 1.00 55.33 ? 27 LEU J O   1 
ATOM   2179 C CB  . LEU J 1 27 ? 156.735 132.490 125.923 1.00 55.33 ? 27 LEU J CB  1 
ATOM   2180 C CG  . LEU J 1 27 ? 157.836 133.293 125.221 1.00 55.33 ? 27 LEU J CG  1 
ATOM   2181 C CD1 . LEU J 1 27 ? 158.700 132.396 124.365 1.00 55.33 ? 27 LEU J CD1 1 
ATOM   2182 C CD2 . LEU J 1 27 ? 157.265 134.433 124.409 1.00 55.33 ? 27 LEU J CD2 1 
ATOM   2183 N N   . SER J 1 28 ? 154.114 129.920 125.415 1.00 59.68 ? 28 SER J N   1 
ATOM   2184 C CA  . SER J 1 28 ? 153.539 128.754 126.088 1.00 59.68 ? 28 SER J CA  1 
ATOM   2185 C C   . SER J 1 28 ? 153.182 127.671 125.080 1.00 59.68 ? 28 SER J C   1 
ATOM   2186 O O   . SER J 1 28 ? 152.045 127.622 124.581 1.00 59.68 ? 28 SER J O   1 
ATOM   2187 C CB  . SER J 1 28 ? 152.316 129.168 126.898 1.00 59.68 ? 28 SER J CB  1 
ATOM   2188 O OG  . SER J 1 28 ? 151.299 129.648 126.042 1.00 59.68 ? 28 SER J OG  1 
ATOM   2189 N N   . PRO J 1 29 ? 154.113 126.776 124.757 1.00 62.30 ? 29 PRO J N   1 
ATOM   2190 C CA  . PRO J 1 29 ? 153.808 125.694 123.815 1.00 62.30 ? 29 PRO J CA  1 
ATOM   2191 C C   . PRO J 1 29 ? 152.749 124.749 124.363 1.00 62.30 ? 29 PRO J C   1 
ATOM   2192 O O   . PRO J 1 29 ? 152.616 124.564 125.573 1.00 62.30 ? 29 PRO J O   1 
ATOM   2193 C CB  . PRO J 1 29 ? 155.154 124.985 123.646 1.00 62.30 ? 29 PRO J CB  1 
ATOM   2194 C CG  . PRO J 1 29 ? 155.916 125.326 124.876 1.00 62.30 ? 29 PRO J CG  1 
ATOM   2195 C CD  . PRO J 1 29 ? 155.498 126.707 125.252 1.00 62.30 ? 29 PRO J CD  1 
ATOM   2196 N N   . THR J 1 30 ? 151.991 124.140 123.452 1.00 65.05 ? 30 THR J N   1 
ATOM   2197 C CA  . THR J 1 30 ? 150.878 123.275 123.818 1.00 65.05 ? 30 THR J CA  1 
ATOM   2198 C C   . THR J 1 30 ? 151.008 121.931 123.112 1.00 65.05 ? 30 THR J C   1 
ATOM   2199 O O   . THR J 1 30 ? 151.386 121.873 121.939 1.00 65.05 ? 30 THR J O   1 
ATOM   2200 C CB  . THR J 1 30 ? 149.532 123.926 123.469 1.00 65.05 ? 30 THR J CB  1 
ATOM   2201 O OG1 . THR J 1 30 ? 149.600 125.331 123.733 1.00 65.05 ? 30 THR J OG1 1 
ATOM   2202 C CG2 . THR J 1 30 ? 148.417 123.334 124.309 1.00 65.05 ? 30 THR J CG2 1 
ATOM   2203 N N   . ASN J 1 31 ? 150.682 120.857 123.836 1.00 66.60 ? 31 ASN J N   1 
ATOM   2204 C CA  . ASN J 1 31 ? 150.742 119.484 123.322 1.00 66.60 ? 31 ASN J CA  1 
ATOM   2205 C C   . ASN J 1 31 ? 152.110 119.167 122.718 1.00 66.60 ? 31 ASN J C   1 
ATOM   2206 O O   . ASN J 1 31 ? 152.222 118.772 121.556 1.00 66.60 ? 31 ASN J O   1 
ATOM   2207 C CB  . ASN J 1 31 ? 149.630 119.213 122.307 1.00 66.60 ? 31 ASN J CB  1 
ATOM   2208 C CG  . ASN J 1 31 ? 148.387 120.032 122.565 1.00 66.60 ? 31 ASN J CG  1 
ATOM   2209 O OD1 . ASN J 1 31 ? 148.244 121.140 122.051 1.00 66.60 ? 31 ASN J OD1 1 
ATOM   2210 N ND2 . ASN J 1 31 ? 147.478 119.491 123.365 1.00 66.60 ? 31 ASN J ND2 1 
ATOM   2211 N N   . VAL J 1 32 ? 153.158 119.333 123.517 1.00 65.77 ? 32 VAL J N   1 
ATOM   2212 C CA  . VAL J 1 32 ? 154.517 119.125 123.045 1.00 65.77 ? 32 VAL J CA  1 
ATOM   2213 C C   . VAL J 1 32 ? 155.123 117.949 123.803 1.00 65.77 ? 32 VAL J C   1 
ATOM   2214 O O   . VAL J 1 32 ? 154.514 117.383 124.710 1.00 65.77 ? 32 VAL J O   1 
ATOM   2215 C CB  . VAL J 1 32 ? 155.392 120.381 123.207 1.00 65.77 ? 32 VAL J CB  1 
ATOM   2216 C CG1 . VAL J 1 32 ? 154.677 121.596 122.642 1.00 65.77 ? 32 VAL J CG1 1 
ATOM   2217 C CG2 . VAL J 1 32 ? 155.796 120.579 124.650 1.00 65.77 ? 32 VAL J CG2 1 
ATOM   2218 N N   . GLY J 1 33 ? 156.340 117.585 123.409 1.00 66.96 ? 33 GLY J N   1 
ATOM   2219 C CA  . GLY J 1 33 ? 157.083 116.558 124.106 1.00 66.96 ? 33 GLY J CA  1 
ATOM   2220 C C   . GLY J 1 33 ? 157.965 117.141 125.187 1.00 66.96 ? 33 GLY J C   1 
ATOM   2221 O O   . GLY J 1 33 ? 157.465 117.720 126.156 1.00 66.96 ? 33 GLY J O   1 
ATOM   2222 N N   . SER J 1 34 ? 159.277 116.995 125.038 1.00 66.15 ? 34 SER J N   1 
ATOM   2223 C CA  . SER J 1 34 ? 160.233 117.559 125.989 1.00 66.15 ? 34 SER J CA  1 
ATOM   2224 C C   . SER J 1 34 ? 160.430 119.034 125.672 1.00 66.15 ? 34 SER J C   1 
ATOM   2225 O O   . SER J 1 34 ? 160.938 119.393 124.609 1.00 66.15 ? 34 SER J O   1 
ATOM   2226 C CB  . SER J 1 34 ? 161.553 116.799 125.928 1.00 66.15 ? 34 SER J CB  1 
ATOM   2227 O OG  . SER J 1 34 ? 162.497 117.345 126.833 1.00 66.15 ? 34 SER J OG  1 
ATOM   2228 N N   . ASN J 1 35 ? 160.019 119.899 126.593 1.00 62.87 ? 35 ASN J N   1 
ATOM   2229 C CA  . ASN J 1 35 ? 160.151 121.338 126.421 1.00 62.87 ? 35 ASN J CA  1 
ATOM   2230 C C   . ASN J 1 35 ? 161.203 121.894 127.370 1.00 62.87 ? 35 ASN J C   1 
ATOM   2231 O O   . ASN J 1 35 ? 161.294 121.479 128.528 1.00 62.87 ? 35 ASN J O   1 
ATOM   2232 C CB  . ASN J 1 35 ? 158.812 122.034 126.661 1.00 62.87 ? 35 ASN J CB  1 
ATOM   2233 C CG  . ASN J 1 35 ? 158.883 123.523 126.422 1.00 62.87 ? 35 ASN J CG  1 
ATOM   2234 O OD1 . ASN J 1 35 ? 158.778 123.984 125.287 1.00 62.87 ? 35 ASN J OD1 1 
ATOM   2235 N ND2 . ASN J 1 35 ? 159.065 124.285 127.490 1.00 62.87 ? 35 ASN J ND2 1 
ATOM   2236 N N   . THR J 1 36 ? 162.001 122.832 126.870 1.00 61.48 ? 36 THR J N   1 
ATOM   2237 C CA  . THR J 1 36 ? 163.048 123.452 127.667 1.00 61.48 ? 36 THR J CA  1 
ATOM   2238 C C   . THR J 1 36 ? 163.167 124.920 127.287 1.00 61.48 ? 36 THR J C   1 
ATOM   2239 O O   . THR J 1 36 ? 163.117 125.266 126.103 1.00 61.48 ? 36 THR J O   1 
ATOM   2240 C CB  . THR J 1 36 ? 164.393 122.746 127.468 1.00 61.48 ? 36 THR J CB  1 
ATOM   2241 O OG1 . THR J 1 36 ? 164.226 121.335 127.650 1.00 61.48 ? 36 THR J OG1 1 
ATOM   2242 C CG2 . THR J 1 36 ? 165.417 123.259 128.465 1.00 61.48 ? 36 THR J CG2 1 
ATOM   2243 N N   . TYR J 1 37 ? 163.325 125.775 128.292 1.00 57.79 ? 37 TYR J N   1 
ATOM   2244 C CA  . TYR J 1 37 ? 163.541 127.200 128.067 1.00 57.79 ? 37 TYR J CA  1 
ATOM   2245 C C   . TYR J 1 37 ? 165.012 127.570 128.201 1.00 57.79 ? 37 TYR J C   1 
ATOM   2246 O O   . TYR J 1 37 ? 165.357 128.746 128.285 1.00 57.79 ? 37 TYR J O   1 
ATOM   2247 C CB  . TYR J 1 37 ? 162.711 128.032 129.042 1.00 57.79 ? 37 TYR J CB  1 
ATOM   2248 C CG  . TYR J 1 37 ? 161.240 128.085 128.712 1.00 57.79 ? 37 TYR J CG  1 
ATOM   2249 C CD1 . TYR J 1 37 ? 160.741 129.045 127.848 1.00 57.79 ? 37 TYR J CD1 1 
ATOM   2250 C CD2 . TYR J 1 37 ? 160.351 127.177 129.264 1.00 57.79 ? 37 TYR J CD2 1 
ATOM   2251 C CE1 . TYR J 1 37 ? 159.401 129.101 127.545 1.00 57.79 ? 37 TYR J CE1 1 
ATOM   2252 C CE2 . TYR J 1 37 ? 159.007 127.226 128.965 1.00 57.79 ? 37 TYR J CE2 1 
ATOM   2253 C CZ  . TYR J 1 37 ? 158.538 128.189 128.107 1.00 57.79 ? 37 TYR J CZ  1 
ATOM   2254 O OH  . TYR J 1 37 ? 157.200 128.245 127.803 1.00 57.79 ? 37 TYR J OH  1 
HETATM 2255 N N   . NH2 J 1 38 ? 165.873 126.558 128.221 1.00 60.94 ? 38 NH2 J N   1 
# 
