data_8QR2
# 
_entry.id   8QR2 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8QR2         pdb_00008qr2 10.2210/pdb8qr2/pdb 
WWPDB D_1292133566 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-16 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8QR2 
_pdbx_database_status.recvd_initial_deposition_date   2023-10-06 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 1 
_pdbx_contact_author.email              gilles.labesse@cbs.cnrs.fr 
_pdbx_contact_author.name_first         Gilles 
_pdbx_contact_author.name_last          Labesse 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-6861-3300 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Gelin, M.'   1 ? 
'Labesse, G.' 2 ? 
# 
loop_
_citation.abstract 
_citation.abstract_id_CAS 
_citation.book_id_ISBN 
_citation.book_publisher 
_citation.book_publisher_city 
_citation.book_title 
_citation.coordinate_linkage 
_citation.country 
_citation.database_id_Medline 
_citation.details 
_citation.id 
_citation.journal_abbrev 
_citation.journal_id_ASTM 
_citation.journal_id_CSD 
_citation.journal_id_ISSN 
_citation.journal_full 
_citation.journal_issue 
_citation.journal_volume 
_citation.language 
_citation.page_first 
_citation.page_last 
_citation.title 
_citation.year 
_citation.database_id_CSD 
_citation.pdbx_database_id_DOI 
_citation.pdbx_database_id_PubMed 
_citation.pdbx_database_id_patent 
_citation.unpublished_flag 
? ? ? ? ? ? ? ?  ? ? primary 'To Be Published'                                ?      0353 ?         ? ? ?  ? ?   ?  
'Crystal structure of ERK2 in complex with a covalently bound macrocyclic ligand' ?    ? ? ? ? ? 
? ? ? ? ? ? ? DK ? ? 1       'Acta Crystallogr., Sect. D: Biol. Crystallogr.' ABCRE6 0766 0907-4449 ? ? 68 ? 352 67 
'Towards automated crystallographic structure refinement with phenix.refine.'     2012 ? ? ? ? ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Gelin, M.'      1 ? 
primary 'Labesse, G.'    2 ? 
primary 'Guichou, J.-F.' 3 ? 
primary 'Pons, J.-L.'    4 ? 
primary 'Barluenga, S.'  5 ? 
primary 'Katickeyan, G.' 6 ? 
primary 'Winssinger, N.' 7 ? 
1       'Liebschner, D.' 8 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Mitogen-activated protein kinase 1' 42311.668 1   ? ? ? ? 
2 non-polymer syn 'SULFATE ION' 96.063    2   ? ? ? ? 
3 non-polymer syn 
;(4~{S},9~{S},10~{S},12~{E})-16-methoxy-4-methyl-9,10,18-tris(oxidanyl)-3-oxabicyclo[12.4.0]octadeca-1(18),12,14,16-tetraene-2,8-dione
;
364.390   1   ? ? ? ? 
4 water       nat water 18.015    376 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   yes 
_entity_poly.pdbx_seq_one_letter_code       
;HHHHHHMAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILL
RFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLL
LNTT(CME)DLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKH
YLDQLNHILGILGSPSQEDLN(CME)IINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQAL
AHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
;
_entity_poly.pdbx_seq_one_letter_code_can   
;HHHHHHMAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILL
RFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLL
LNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQ
LNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQY
YDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'SULFATE ION' SO4 
3 
;(4~{S},9~{S},10~{S},12~{E})-16-methoxy-4-methyl-9,10,18-tris(oxidanyl)-3-oxabicyclo[12.4.0]octadeca-1(18),12,14,16-tetraene-2,8-dione
;
WNT 
4 water HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   HIS n 
1 2   HIS n 
1 3   HIS n 
1 4   HIS n 
1 5   HIS n 
1 6   HIS n 
1 7   MET n 
1 8   ALA n 
1 9   ALA n 
1 10  ALA n 
1 11  ALA n 
1 12  ALA n 
1 13  ALA n 
1 14  GLY n 
1 15  PRO n 
1 16  GLU n 
1 17  MET n 
1 18  VAL n 
1 19  ARG n 
1 20  GLY n 
1 21  GLN n 
1 22  VAL n 
1 23  PHE n 
1 24  ASP n 
1 25  VAL n 
1 26  GLY n 
1 27  PRO n 
1 28  ARG n 
1 29  TYR n 
1 30  THR n 
1 31  ASN n 
1 32  LEU n 
1 33  SER n 
1 34  TYR n 
1 35  ILE n 
1 36  GLY n 
1 37  GLU n 
1 38  GLY n 
1 39  ALA n 
1 40  TYR n 
1 41  GLY n 
1 42  MET n 
1 43  VAL n 
1 44  CYS n 
1 45  SER n 
1 46  ALA n 
1 47  TYR n 
1 48  ASP n 
1 49  ASN n 
1 50  LEU n 
1 51  ASN n 
1 52  LYS n 
1 53  VAL n 
1 54  ARG n 
1 55  VAL n 
1 56  ALA n 
1 57  ILE n 
1 58  LYS n 
1 59  LYS n 
1 60  ILE n 
1 61  SER n 
1 62  PRO n 
1 63  PHE n 
1 64  GLU n 
1 65  HIS n 
1 66  GLN n 
1 67  THR n 
1 68  TYR n 
1 69  CYS n 
1 70  GLN n 
1 71  ARG n 
1 72  THR n 
1 73  LEU n 
1 74  ARG n 
1 75  GLU n 
1 76  ILE n 
1 77  LYS n 
1 78  ILE n 
1 79  LEU n 
1 80  LEU n 
1 81  ARG n 
1 82  PHE n 
1 83  ARG n 
1 84  HIS n 
1 85  GLU n 
1 86  ASN n 
1 87  ILE n 
1 88  ILE n 
1 89  GLY n 
1 90  ILE n 
1 91  ASN n 
1 92  ASP n 
1 93  ILE n 
1 94  ILE n 
1 95  ARG n 
1 96  ALA n 
1 97  PRO n 
1 98  THR n 
1 99  ILE n 
1 100 GLU n 
1 101 GLN n 
1 102 MET n 
1 103 LYS n 
1 104 ASP n 
1 105 VAL n 
1 106 TYR n 
1 107 ILE n 
1 108 VAL n 
1 109 GLN n 
1 110 ASP n 
1 111 LEU n 
1 112 MET n 
1 113 GLU n 
1 114 THR n 
1 115 ASP n 
1 116 LEU n 
1 117 TYR n 
1 118 LYS n 
1 119 LEU n 
1 120 LEU n 
1 121 LYS n 
1 122 THR n 
1 123 GLN n 
1 124 HIS n 
1 125 LEU n 
1 126 SER n 
1 127 ASN n 
1 128 ASP n 
1 129 HIS n 
1 130 ILE n 
1 131 CYS n 
1 132 TYR n 
1 133 PHE n 
1 134 LEU n 
1 135 TYR n 
1 136 GLN n 
1 137 ILE n 
1 138 LEU n 
1 139 ARG n 
1 140 GLY n 
1 141 LEU n 
1 142 LYS n 
1 143 TYR n 
1 144 ILE n 
1 145 HIS n 
1 146 SER n 
1 147 ALA n 
1 148 ASN n 
1 149 VAL n 
1 150 LEU n 
1 151 HIS n 
1 152 ARG n 
1 153 ASP n 
1 154 LEU n 
1 155 LYS n 
1 156 PRO n 
1 157 SER n 
1 158 ASN n 
1 159 LEU n 
1 160 LEU n 
1 161 LEU n 
1 162 ASN n 
1 163 THR n 
1 164 THR n 
1 165 CME n 
1 166 ASP n 
1 167 LEU n 
1 168 LYS n 
1 169 ILE n 
1 170 CYS n 
1 171 ASP n 
1 172 PHE n 
1 173 GLY n 
1 174 LEU n 
1 175 ALA n 
1 176 ARG n 
1 177 VAL n 
1 178 ALA n 
1 179 ASP n 
1 180 PRO n 
1 181 ASP n 
1 182 HIS n 
1 183 ASP n 
1 184 HIS n 
1 185 THR n 
1 186 GLY n 
1 187 PHE n 
1 188 LEU n 
1 189 THR n 
1 190 GLU n 
1 191 TYR n 
1 192 VAL n 
1 193 ALA n 
1 194 THR n 
1 195 ARG n 
1 196 TRP n 
1 197 TYR n 
1 198 ARG n 
1 199 ALA n 
1 200 PRO n 
1 201 GLU n 
1 202 ILE n 
1 203 MET n 
1 204 LEU n 
1 205 ASN n 
1 206 SER n 
1 207 LYS n 
1 208 GLY n 
1 209 TYR n 
1 210 THR n 
1 211 LYS n 
1 212 SER n 
1 213 ILE n 
1 214 ASP n 
1 215 ILE n 
1 216 TRP n 
1 217 SER n 
1 218 VAL n 
1 219 GLY n 
1 220 CYS n 
1 221 ILE n 
1 222 LEU n 
1 223 ALA n 
1 224 GLU n 
1 225 MET n 
1 226 LEU n 
1 227 SER n 
1 228 ASN n 
1 229 ARG n 
1 230 PRO n 
1 231 ILE n 
1 232 PHE n 
1 233 PRO n 
1 234 GLY n 
1 235 LYS n 
1 236 HIS n 
1 237 TYR n 
1 238 LEU n 
1 239 ASP n 
1 240 GLN n 
1 241 LEU n 
1 242 ASN n 
1 243 HIS n 
1 244 ILE n 
1 245 LEU n 
1 246 GLY n 
1 247 ILE n 
1 248 LEU n 
1 249 GLY n 
1 250 SER n 
1 251 PRO n 
1 252 SER n 
1 253 GLN n 
1 254 GLU n 
1 255 ASP n 
1 256 LEU n 
1 257 ASN n 
1 258 CME n 
1 259 ILE n 
1 260 ILE n 
1 261 ASN n 
1 262 LEU n 
1 263 LYS n 
1 264 ALA n 
1 265 ARG n 
1 266 ASN n 
1 267 TYR n 
1 268 LEU n 
1 269 LEU n 
1 270 SER n 
1 271 LEU n 
1 272 PRO n 
1 273 HIS n 
1 274 LYS n 
1 275 ASN n 
1 276 LYS n 
1 277 VAL n 
1 278 PRO n 
1 279 TRP n 
1 280 ASN n 
1 281 ARG n 
1 282 LEU n 
1 283 PHE n 
1 284 PRO n 
1 285 ASN n 
1 286 ALA n 
1 287 ASP n 
1 288 SER n 
1 289 LYS n 
1 290 ALA n 
1 291 LEU n 
1 292 ASP n 
1 293 LEU n 
1 294 LEU n 
1 295 ASP n 
1 296 LYS n 
1 297 MET n 
1 298 LEU n 
1 299 THR n 
1 300 PHE n 
1 301 ASN n 
1 302 PRO n 
1 303 HIS n 
1 304 LYS n 
1 305 ARG n 
1 306 ILE n 
1 307 GLU n 
1 308 VAL n 
1 309 GLU n 
1 310 GLN n 
1 311 ALA n 
1 312 LEU n 
1 313 ALA n 
1 314 HIS n 
1 315 PRO n 
1 316 TYR n 
1 317 LEU n 
1 318 GLU n 
1 319 GLN n 
1 320 TYR n 
1 321 TYR n 
1 322 ASP n 
1 323 PRO n 
1 324 SER n 
1 325 ASP n 
1 326 GLU n 
1 327 PRO n 
1 328 ILE n 
1 329 ALA n 
1 330 GLU n 
1 331 ALA n 
1 332 PRO n 
1 333 PHE n 
1 334 LYS n 
1 335 PHE n 
1 336 ASP n 
1 337 MET n 
1 338 GLU n 
1 339 LEU n 
1 340 ASP n 
1 341 ASP n 
1 342 LEU n 
1 343 PRO n 
1 344 LYS n 
1 345 GLU n 
1 346 LYS n 
1 347 LEU n 
1 348 LYS n 
1 349 GLU n 
1 350 LEU n 
1 351 ILE n 
1 352 PHE n 
1 353 GLU n 
1 354 GLU n 
1 355 THR n 
1 356 ALA n 
1 357 ARG n 
1 358 PHE n 
1 359 GLN n 
1 360 PRO n 
1 361 GLY n 
1 362 TYR n 
1 363 ARG n 
1 364 SER n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   364 
_entity_src_gen.gene_src_common_name               'Norway rat' 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 Mapk1 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Rattus norvegicus' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     10116 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          plasmid 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CME 'L-peptide linking' n 'S,S-(2-HYDROXYETHYL)THIOCYSTEINE' ? 'C5 H11 N O3 S2' 197.276 
CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3'     105.093 
SO4 non-polymer         . 'SULFATE ION' ? 'O4 S -2'        96.063  
THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2'    117.146 
WNT non-polymer         . 
;(4~{S},9~{S},10~{S},12~{E})-16-methoxy-4-methyl-9,10,18-tris(oxidanyl)-3-oxabicyclo[12.4.0]octadeca-1(18),12,14,16-tetraene-2,8-dione
;
? 'C19 H24 O7'     364.390 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   HIS 1   -5  ?   ?   ?   A . n 
A 1 2   HIS 2   -4  ?   ?   ?   A . n 
A 1 3   HIS 3   -3  ?   ?   ?   A . n 
A 1 4   HIS 4   -2  ?   ?   ?   A . n 
A 1 5   HIS 5   -1  ?   ?   ?   A . n 
A 1 6   HIS 6   0   ?   ?   ?   A . n 
A 1 7   MET 7   1   ?   ?   ?   A . n 
A 1 8   ALA 8   2   ?   ?   ?   A . n 
A 1 9   ALA 9   3   ?   ?   ?   A . n 
A 1 10  ALA 10  4   ?   ?   ?   A . n 
A 1 11  ALA 11  5   ?   ?   ?   A . n 
A 1 12  ALA 12  6   ?   ?   ?   A . n 
A 1 13  ALA 13  7   ?   ?   ?   A . n 
A 1 14  GLY 14  8   ?   ?   ?   A . n 
A 1 15  PRO 15  9   9   PRO PRO A . n 
A 1 16  GLU 16  10  10  GLU GLU A . n 
A 1 17  MET 17  11  11  MET MET A . n 
A 1 18  VAL 18  12  12  VAL VAL A . n 
A 1 19  ARG 19  13  13  ARG ARG A . n 
A 1 20  GLY 20  14  14  GLY GLY A . n 
A 1 21  GLN 21  15  15  GLN GLN A . n 
A 1 22  VAL 22  16  16  VAL VAL A . n 
A 1 23  PHE 23  17  17  PHE PHE A . n 
A 1 24  ASP 24  18  18  ASP ASP A . n 
A 1 25  VAL 25  19  19  VAL VAL A . n 
A 1 26  GLY 26  20  20  GLY GLY A . n 
A 1 27  PRO 27  21  21  PRO PRO A . n 
A 1 28  ARG 28  22  22  ARG ARG A . n 
A 1 29  TYR 29  23  23  TYR TYR A . n 
A 1 30  THR 30  24  24  THR THR A . n 
A 1 31  ASN 31  25  25  ASN ASN A . n 
A 1 32  LEU 32  26  26  LEU LEU A . n 
A 1 33  SER 33  27  27  SER SER A . n 
A 1 34  TYR 34  28  28  TYR TYR A . n 
A 1 35  ILE 35  29  29  ILE ILE A . n 
A 1 36  GLY 36  30  30  GLY GLY A . n 
A 1 37  GLU 37  31  31  GLU GLU A . n 
A 1 38  GLY 38  32  32  GLY GLY A . n 
A 1 39  ALA 39  33  33  ALA ALA A . n 
A 1 40  TYR 40  34  34  TYR TYR A . n 
A 1 41  GLY 41  35  35  GLY GLY A . n 
A 1 42  MET 42  36  36  MET MET A . n 
A 1 43  VAL 43  37  37  VAL VAL A . n 
A 1 44  CYS 44  38  38  CYS CYS A . n 
A 1 45  SER 45  39  39  SER SER A . n 
A 1 46  ALA 46  40  40  ALA ALA A . n 
A 1 47  TYR 47  41  41  TYR TYR A . n 
A 1 48  ASP 48  42  42  ASP ASP A . n 
A 1 49  ASN 49  43  43  ASN ASN A . n 
A 1 50  LEU 50  44  44  LEU LEU A . n 
A 1 51  ASN 51  45  45  ASN ASN A . n 
A 1 52  LYS 52  46  46  LYS LYS A . n 
A 1 53  VAL 53  47  47  VAL VAL A . n 
A 1 54  ARG 54  48  48  ARG ARG A . n 
A 1 55  VAL 55  49  49  VAL VAL A . n 
A 1 56  ALA 56  50  50  ALA ALA A . n 
A 1 57  ILE 57  51  51  ILE ILE A . n 
A 1 58  LYS 58  52  52  LYS LYS A . n 
A 1 59  LYS 59  53  53  LYS LYS A . n 
A 1 60  ILE 60  54  54  ILE ILE A . n 
A 1 61  SER 61  55  55  SER SER A . n 
A 1 62  PRO 62  56  56  PRO PRO A . n 
A 1 63  PHE 63  57  57  PHE PHE A . n 
A 1 64  GLU 64  58  58  GLU GLU A . n 
A 1 65  HIS 65  59  59  HIS HIS A . n 
A 1 66  GLN 66  60  60  GLN GLN A . n 
A 1 67  THR 67  61  61  THR THR A . n 
A 1 68  TYR 68  62  62  TYR TYR A . n 
A 1 69  CYS 69  63  63  CYS CYS A . n 
A 1 70  GLN 70  64  64  GLN GLN A . n 
A 1 71  ARG 71  65  65  ARG ARG A . n 
A 1 72  THR 72  66  66  THR THR A . n 
A 1 73  LEU 73  67  67  LEU LEU A . n 
A 1 74  ARG 74  68  68  ARG ARG A . n 
A 1 75  GLU 75  69  69  GLU GLU A . n 
A 1 76  ILE 76  70  70  ILE ILE A . n 
A 1 77  LYS 77  71  71  LYS LYS A . n 
A 1 78  ILE 78  72  72  ILE ILE A . n 
A 1 79  LEU 79  73  73  LEU LEU A . n 
A 1 80  LEU 80  74  74  LEU LEU A . n 
A 1 81  ARG 81  75  75  ARG ARG A . n 
A 1 82  PHE 82  76  76  PHE PHE A . n 
A 1 83  ARG 83  77  77  ARG ARG A . n 
A 1 84  HIS 84  78  78  HIS HIS A . n 
A 1 85  GLU 85  79  79  GLU GLU A . n 
A 1 86  ASN 86  80  80  ASN ASN A . n 
A 1 87  ILE 87  81  81  ILE ILE A . n 
A 1 88  ILE 88  82  82  ILE ILE A . n 
A 1 89  GLY 89  83  83  GLY GLY A . n 
A 1 90  ILE 90  84  84  ILE ILE A . n 
A 1 91  ASN 91  85  85  ASN ASN A . n 
A 1 92  ASP 92  86  86  ASP ASP A . n 
A 1 93  ILE 93  87  87  ILE ILE A . n 
A 1 94  ILE 94  88  88  ILE ILE A . n 
A 1 95  ARG 95  89  89  ARG ARG A . n 
A 1 96  ALA 96  90  90  ALA ALA A . n 
A 1 97  PRO 97  91  91  PRO PRO A . n 
A 1 98  THR 98  92  92  THR THR A . n 
A 1 99  ILE 99  93  93  ILE ILE A . n 
A 1 100 GLU 100 94  94  GLU GLU A . n 
A 1 101 GLN 101 95  95  GLN GLN A . n 
A 1 102 MET 102 96  96  MET MET A . n 
A 1 103 LYS 103 97  97  LYS LYS A . n 
A 1 104 ASP 104 98  98  ASP ASP A . n 
A 1 105 VAL 105 99  99  VAL VAL A . n 
A 1 106 TYR 106 100 100 TYR TYR A . n 
A 1 107 ILE 107 101 101 ILE ILE A . n 
A 1 108 VAL 108 102 102 VAL VAL A . n 
A 1 109 GLN 109 103 103 GLN GLN A . n 
A 1 110 ASP 110 104 104 ASP ASP A . n 
A 1 111 LEU 111 105 105 LEU LEU A . n 
A 1 112 MET 112 106 106 MET MET A . n 
A 1 113 GLU 113 107 107 GLU GLU A . n 
A 1 114 THR 114 108 108 THR THR A . n 
A 1 115 ASP 115 109 109 ASP ASP A . n 
A 1 116 LEU 116 110 110 LEU LEU A . n 
A 1 117 TYR 117 111 111 TYR TYR A . n 
A 1 118 LYS 118 112 112 LYS LYS A . n 
A 1 119 LEU 119 113 113 LEU LEU A . n 
A 1 120 LEU 120 114 114 LEU LEU A . n 
A 1 121 LYS 121 115 115 LYS LYS A . n 
A 1 122 THR 122 116 116 THR THR A . n 
A 1 123 GLN 123 117 117 GLN GLN A . n 
A 1 124 HIS 124 118 118 HIS HIS A . n 
A 1 125 LEU 125 119 119 LEU LEU A . n 
A 1 126 SER 126 120 120 SER SER A . n 
A 1 127 ASN 127 121 121 ASN ASN A . n 
A 1 128 ASP 128 122 122 ASP ASP A . n 
A 1 129 HIS 129 123 123 HIS HIS A . n 
A 1 130 ILE 130 124 124 ILE ILE A . n 
A 1 131 CYS 131 125 125 CYS CYS A . n 
A 1 132 TYR 132 126 126 TYR TYR A . n 
A 1 133 PHE 133 127 127 PHE PHE A . n 
A 1 134 LEU 134 128 128 LEU LEU A . n 
A 1 135 TYR 135 129 129 TYR TYR A . n 
A 1 136 GLN 136 130 130 GLN GLN A . n 
A 1 137 ILE 137 131 131 ILE ILE A . n 
A 1 138 LEU 138 132 132 LEU LEU A . n 
A 1 139 ARG 139 133 133 ARG ARG A . n 
A 1 140 GLY 140 134 134 GLY GLY A . n 
A 1 141 LEU 141 135 135 LEU LEU A . n 
A 1 142 LYS 142 136 136 LYS LYS A . n 
A 1 143 TYR 143 137 137 TYR TYR A . n 
A 1 144 ILE 144 138 138 ILE ILE A . n 
A 1 145 HIS 145 139 139 HIS HIS A . n 
A 1 146 SER 146 140 140 SER SER A . n 
A 1 147 ALA 147 141 141 ALA ALA A . n 
A 1 148 ASN 148 142 142 ASN ASN A . n 
A 1 149 VAL 149 143 143 VAL VAL A . n 
A 1 150 LEU 150 144 144 LEU LEU A . n 
A 1 151 HIS 151 145 145 HIS HIS A . n 
A 1 152 ARG 152 146 146 ARG ARG A . n 
A 1 153 ASP 153 147 147 ASP ASP A . n 
A 1 154 LEU 154 148 148 LEU LEU A . n 
A 1 155 LYS 155 149 149 LYS LYS A . n 
A 1 156 PRO 156 150 150 PRO PRO A . n 
A 1 157 SER 157 151 151 SER SER A . n 
A 1 158 ASN 158 152 152 ASN ASN A . n 
A 1 159 LEU 159 153 153 LEU LEU A . n 
A 1 160 LEU 160 154 154 LEU LEU A . n 
A 1 161 LEU 161 155 155 LEU LEU A . n 
A 1 162 ASN 162 156 156 ASN ASN A . n 
A 1 163 THR 163 157 157 THR THR A . n 
A 1 164 THR 164 158 158 THR THR A . n 
A 1 165 CME 165 159 159 CME CME A . n 
A 1 166 ASP 166 160 160 ASP ASP A . n 
A 1 167 LEU 167 161 161 LEU LEU A . n 
A 1 168 LYS 168 162 162 LYS LYS A . n 
A 1 169 ILE 169 163 163 ILE ILE A . n 
A 1 170 CYS 170 164 164 CYS CYS A . n 
A 1 171 ASP 171 165 165 ASP ASP A . n 
A 1 172 PHE 172 166 166 PHE PHE A . n 
A 1 173 GLY 173 167 167 GLY GLY A . n 
A 1 174 LEU 174 168 168 LEU LEU A . n 
A 1 175 ALA 175 169 169 ALA ALA A . n 
A 1 176 ARG 176 170 170 ARG ARG A . n 
A 1 177 VAL 177 171 171 VAL VAL A . n 
A 1 178 ALA 178 172 172 ALA ALA A . n 
A 1 179 ASP 179 173 173 ASP ASP A . n 
A 1 180 PRO 180 174 174 PRO PRO A . n 
A 1 181 ASP 181 175 175 ASP ASP A . n 
A 1 182 HIS 182 176 176 HIS HIS A . n 
A 1 183 ASP 183 177 177 ASP ASP A . n 
A 1 184 HIS 184 178 178 HIS HIS A . n 
A 1 185 THR 185 179 179 THR THR A . n 
A 1 186 GLY 186 180 180 GLY GLY A . n 
A 1 187 PHE 187 181 181 PHE PHE A . n 
A 1 188 LEU 188 182 182 LEU LEU A . n 
A 1 189 THR 189 183 183 THR THR A . n 
A 1 190 GLU 190 184 184 GLU GLU A . n 
A 1 191 TYR 191 185 185 TYR TYR A . n 
A 1 192 VAL 192 186 186 VAL VAL A . n 
A 1 193 ALA 193 187 187 ALA ALA A . n 
A 1 194 THR 194 188 188 THR THR A . n 
A 1 195 ARG 195 189 189 ARG ARG A . n 
A 1 196 TRP 196 190 190 TRP TRP A . n 
A 1 197 TYR 197 191 191 TYR TYR A . n 
A 1 198 ARG 198 192 192 ARG ARG A . n 
A 1 199 ALA 199 193 193 ALA ALA A . n 
A 1 200 PRO 200 194 194 PRO PRO A . n 
A 1 201 GLU 201 195 195 GLU GLU A . n 
A 1 202 ILE 202 196 196 ILE ILE A . n 
A 1 203 MET 203 197 197 MET MET A . n 
A 1 204 LEU 204 198 198 LEU LEU A . n 
A 1 205 ASN 205 199 199 ASN ASN A . n 
A 1 206 SER 206 200 200 SER SER A . n 
A 1 207 LYS 207 201 201 LYS LYS A . n 
A 1 208 GLY 208 202 202 GLY GLY A . n 
A 1 209 TYR 209 203 203 TYR TYR A . n 
A 1 210 THR 210 204 204 THR THR A . n 
A 1 211 LYS 211 205 205 LYS LYS A . n 
A 1 212 SER 212 206 206 SER SER A . n 
A 1 213 ILE 213 207 207 ILE ILE A . n 
A 1 214 ASP 214 208 208 ASP ASP A . n 
A 1 215 ILE 215 209 209 ILE ILE A . n 
A 1 216 TRP 216 210 210 TRP TRP A . n 
A 1 217 SER 217 211 211 SER SER A . n 
A 1 218 VAL 218 212 212 VAL VAL A . n 
A 1 219 GLY 219 213 213 GLY GLY A . n 
A 1 220 CYS 220 214 214 CYS CYS A . n 
A 1 221 ILE 221 215 215 ILE ILE A . n 
A 1 222 LEU 222 216 216 LEU LEU A . n 
A 1 223 ALA 223 217 217 ALA ALA A . n 
A 1 224 GLU 224 218 218 GLU GLU A . n 
A 1 225 MET 225 219 219 MET MET A . n 
A 1 226 LEU 226 220 220 LEU LEU A . n 
A 1 227 SER 227 221 221 SER SER A . n 
A 1 228 ASN 228 222 222 ASN ASN A . n 
A 1 229 ARG 229 223 223 ARG ARG A . n 
A 1 230 PRO 230 224 224 PRO PRO A . n 
A 1 231 ILE 231 225 225 ILE ILE A . n 
A 1 232 PHE 232 226 226 PHE PHE A . n 
A 1 233 PRO 233 227 227 PRO PRO A . n 
A 1 234 GLY 234 228 228 GLY GLY A . n 
A 1 235 LYS 235 229 229 LYS LYS A . n 
A 1 236 HIS 236 230 230 HIS HIS A . n 
A 1 237 TYR 237 231 231 TYR TYR A . n 
A 1 238 LEU 238 232 232 LEU LEU A . n 
A 1 239 ASP 239 233 233 ASP ASP A . n 
A 1 240 GLN 240 234 234 GLN GLN A . n 
A 1 241 LEU 241 235 235 LEU LEU A . n 
A 1 242 ASN 242 236 236 ASN ASN A . n 
A 1 243 HIS 243 237 237 HIS HIS A . n 
A 1 244 ILE 244 238 238 ILE ILE A . n 
A 1 245 LEU 245 239 239 LEU LEU A . n 
A 1 246 GLY 246 240 240 GLY GLY A . n 
A 1 247 ILE 247 241 241 ILE ILE A . n 
A 1 248 LEU 248 242 242 LEU LEU A . n 
A 1 249 GLY 249 243 243 GLY GLY A . n 
A 1 250 SER 250 244 244 SER SER A . n 
A 1 251 PRO 251 245 245 PRO PRO A . n 
A 1 252 SER 252 246 246 SER SER A . n 
A 1 253 GLN 253 247 247 GLN GLN A . n 
A 1 254 GLU 254 248 248 GLU GLU A . n 
A 1 255 ASP 255 249 249 ASP ASP A . n 
A 1 256 LEU 256 250 250 LEU LEU A . n 
A 1 257 ASN 257 251 251 ASN ASN A . n 
A 1 258 CME 258 252 252 CME CME A . n 
A 1 259 ILE 259 253 253 ILE ILE A . n 
A 1 260 ILE 260 254 254 ILE ILE A . n 
A 1 261 ASN 261 255 255 ASN ASN A . n 
A 1 262 LEU 262 256 256 LEU LEU A . n 
A 1 263 LYS 263 257 257 LYS LYS A . n 
A 1 264 ALA 264 258 258 ALA ALA A . n 
A 1 265 ARG 265 259 259 ARG ARG A . n 
A 1 266 ASN 266 260 260 ASN ASN A . n 
A 1 267 TYR 267 261 261 TYR TYR A . n 
A 1 268 LEU 268 262 262 LEU LEU A . n 
A 1 269 LEU 269 263 263 LEU LEU A . n 
A 1 270 SER 270 264 264 SER SER A . n 
A 1 271 LEU 271 265 265 LEU LEU A . n 
A 1 272 PRO 272 266 266 PRO PRO A . n 
A 1 273 HIS 273 267 267 HIS HIS A . n 
A 1 274 LYS 274 268 268 LYS LYS A . n 
A 1 275 ASN 275 269 269 ASN ASN A . n 
A 1 276 LYS 276 270 270 LYS LYS A . n 
A 1 277 VAL 277 271 271 VAL VAL A . n 
A 1 278 PRO 278 272 272 PRO PRO A . n 
A 1 279 TRP 279 273 273 TRP TRP A . n 
A 1 280 ASN 280 274 274 ASN ASN A . n 
A 1 281 ARG 281 275 275 ARG ARG A . n 
A 1 282 LEU 282 276 276 LEU LEU A . n 
A 1 283 PHE 283 277 277 PHE PHE A . n 
A 1 284 PRO 284 278 278 PRO PRO A . n 
A 1 285 ASN 285 279 279 ASN ASN A . n 
A 1 286 ALA 286 280 280 ALA ALA A . n 
A 1 287 ASP 287 281 281 ASP ASP A . n 
A 1 288 SER 288 282 282 SER SER A . n 
A 1 289 LYS 289 283 283 LYS LYS A . n 
A 1 290 ALA 290 284 284 ALA ALA A . n 
A 1 291 LEU 291 285 285 LEU LEU A . n 
A 1 292 ASP 292 286 286 ASP ASP A . n 
A 1 293 LEU 293 287 287 LEU LEU A . n 
A 1 294 LEU 294 288 288 LEU LEU A . n 
A 1 295 ASP 295 289 289 ASP ASP A . n 
A 1 296 LYS 296 290 290 LYS LYS A . n 
A 1 297 MET 297 291 291 MET MET A . n 
A 1 298 LEU 298 292 292 LEU LEU A . n 
A 1 299 THR 299 293 293 THR THR A . n 
A 1 300 PHE 300 294 294 PHE PHE A . n 
A 1 301 ASN 301 295 295 ASN ASN A . n 
A 1 302 PRO 302 296 296 PRO PRO A . n 
A 1 303 HIS 303 297 297 HIS HIS A . n 
A 1 304 LYS 304 298 298 LYS LYS A . n 
A 1 305 ARG 305 299 299 ARG ARG A . n 
A 1 306 ILE 306 300 300 ILE ILE A . n 
A 1 307 GLU 307 301 301 GLU GLU A . n 
A 1 308 VAL 308 302 302 VAL VAL A . n 
A 1 309 GLU 309 303 303 GLU GLU A . n 
A 1 310 GLN 310 304 304 GLN GLN A . n 
A 1 311 ALA 311 305 305 ALA ALA A . n 
A 1 312 LEU 312 306 306 LEU LEU A . n 
A 1 313 ALA 313 307 307 ALA ALA A . n 
A 1 314 HIS 314 308 308 HIS HIS A . n 
A 1 315 PRO 315 309 309 PRO PRO A . n 
A 1 316 TYR 316 310 310 TYR TYR A . n 
A 1 317 LEU 317 311 311 LEU LEU A . n 
A 1 318 GLU 318 312 312 GLU GLU A . n 
A 1 319 GLN 319 313 313 GLN GLN A . n 
A 1 320 TYR 320 314 314 TYR TYR A . n 
A 1 321 TYR 321 315 315 TYR TYR A . n 
A 1 322 ASP 322 316 316 ASP ASP A . n 
A 1 323 PRO 323 317 317 PRO PRO A . n 
A 1 324 SER 324 318 318 SER SER A . n 
A 1 325 ASP 325 319 319 ASP ASP A . n 
A 1 326 GLU 326 320 320 GLU GLU A . n 
A 1 327 PRO 327 321 321 PRO PRO A . n 
A 1 328 ILE 328 322 322 ILE ILE A . n 
A 1 329 ALA 329 323 323 ALA ALA A . n 
A 1 330 GLU 330 324 324 GLU GLU A . n 
A 1 331 ALA 331 325 325 ALA ALA A . n 
A 1 332 PRO 332 326 326 PRO PRO A . n 
A 1 333 PHE 333 327 327 PHE PHE A . n 
A 1 334 LYS 334 328 ?   ?   ?   A . n 
A 1 335 PHE 335 329 ?   ?   ?   A . n 
A 1 336 ASP 336 330 ?   ?   ?   A . n 
A 1 337 MET 337 331 ?   ?   ?   A . n 
A 1 338 GLU 338 332 ?   ?   ?   A . n 
A 1 339 LEU 339 333 ?   ?   ?   A . n 
A 1 340 ASP 340 334 334 ASP ASP A . n 
A 1 341 ASP 341 335 335 ASP ASP A . n 
A 1 342 LEU 342 336 336 LEU LEU A . n 
A 1 343 PRO 343 337 337 PRO PRO A . n 
A 1 344 LYS 344 338 338 LYS LYS A . n 
A 1 345 GLU 345 339 339 GLU GLU A . n 
A 1 346 LYS 346 340 340 LYS LYS A . n 
A 1 347 LEU 347 341 341 LEU LEU A . n 
A 1 348 LYS 348 342 342 LYS LYS A . n 
A 1 349 GLU 349 343 343 GLU GLU A . n 
A 1 350 LEU 350 344 344 LEU LEU A . n 
A 1 351 ILE 351 345 345 ILE ILE A . n 
A 1 352 PHE 352 346 346 PHE PHE A . n 
A 1 353 GLU 353 347 347 GLU GLU A . n 
A 1 354 GLU 354 348 348 GLU GLU A . n 
A 1 355 THR 355 349 349 THR THR A . n 
A 1 356 ALA 356 350 350 ALA ALA A . n 
A 1 357 ARG 357 351 351 ARG ARG A . n 
A 1 358 PHE 358 352 352 PHE PHE A . n 
A 1 359 GLN 359 353 353 GLN GLN A . n 
A 1 360 PRO 360 354 354 PRO PRO A . n 
A 1 361 GLY 361 355 ?   ?   ?   A . n 
A 1 362 TYR 362 356 ?   ?   ?   A . n 
A 1 363 ARG 363 357 ?   ?   ?   A . n 
A 1 364 SER 364 358 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        WNT 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   WNT 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 SO4 1   401 1   SO4 SO4 A . 
C 2 SO4 1   402 2   SO4 SO4 A . 
D 3 WNT 1   403 1   WNT 215 A . 
E 4 HOH 1   501 240 HOH HOH A . 
E 4 HOH 2   502 452 HOH HOH A . 
E 4 HOH 3   503 248 HOH HOH A . 
E 4 HOH 4   504 151 HOH HOH A . 
E 4 HOH 5   505 434 HOH HOH A . 
E 4 HOH 6   506 345 HOH HOH A . 
E 4 HOH 7   507 274 HOH HOH A . 
E 4 HOH 8   508 446 HOH HOH A . 
E 4 HOH 9   509 124 HOH HOH A . 
E 4 HOH 10  510 101 HOH HOH A . 
E 4 HOH 11  511 9   HOH HOH A . 
E 4 HOH 12  512 404 HOH HOH A . 
E 4 HOH 13  513 322 HOH HOH A . 
E 4 HOH 14  514 90  HOH HOH A . 
E 4 HOH 15  515 279 HOH HOH A . 
E 4 HOH 16  516 199 HOH HOH A . 
E 4 HOH 17  517 94  HOH HOH A . 
E 4 HOH 18  518 213 HOH HOH A . 
E 4 HOH 19  519 28  HOH HOH A . 
E 4 HOH 20  520 397 HOH HOH A . 
E 4 HOH 21  521 195 HOH HOH A . 
E 4 HOH 22  522 281 HOH HOH A . 
E 4 HOH 23  523 410 HOH HOH A . 
E 4 HOH 24  524 150 HOH HOH A . 
E 4 HOH 25  525 373 HOH HOH A . 
E 4 HOH 26  526 178 HOH HOH A . 
E 4 HOH 27  527 275 HOH HOH A . 
E 4 HOH 28  528 135 HOH HOH A . 
E 4 HOH 29  529 14  HOH HOH A . 
E 4 HOH 30  530 41  HOH HOH A . 
E 4 HOH 31  531 439 HOH HOH A . 
E 4 HOH 32  532 136 HOH HOH A . 
E 4 HOH 33  533 47  HOH HOH A . 
E 4 HOH 34  534 258 HOH HOH A . 
E 4 HOH 35  535 83  HOH HOH A . 
E 4 HOH 36  536 454 HOH HOH A . 
E 4 HOH 37  537 52  HOH HOH A . 
E 4 HOH 38  538 6   HOH HOH A . 
E 4 HOH 39  539 137 HOH HOH A . 
E 4 HOH 40  540 314 HOH HOH A . 
E 4 HOH 41  541 55  HOH HOH A . 
E 4 HOH 42  542 67  HOH HOH A . 
E 4 HOH 43  543 100 HOH HOH A . 
E 4 HOH 44  544 269 HOH HOH A . 
E 4 HOH 45  545 243 HOH HOH A . 
E 4 HOH 46  546 89  HOH HOH A . 
E 4 HOH 47  547 457 HOH HOH A . 
E 4 HOH 48  548 39  HOH HOH A . 
E 4 HOH 49  549 156 HOH HOH A . 
E 4 HOH 50  550 24  HOH HOH A . 
E 4 HOH 51  551 107 HOH HOH A . 
E 4 HOH 52  552 169 HOH HOH A . 
E 4 HOH 53  553 292 HOH HOH A . 
E 4 HOH 54  554 143 HOH HOH A . 
E 4 HOH 55  555 432 HOH HOH A . 
E 4 HOH 56  556 33  HOH HOH A . 
E 4 HOH 57  557 236 HOH HOH A . 
E 4 HOH 58  558 296 HOH HOH A . 
E 4 HOH 59  559 398 HOH HOH A . 
E 4 HOH 60  560 180 HOH HOH A . 
E 4 HOH 61  561 182 HOH HOH A . 
E 4 HOH 62  562 71  HOH HOH A . 
E 4 HOH 63  563 368 HOH HOH A . 
E 4 HOH 64  564 85  HOH HOH A . 
E 4 HOH 65  565 401 HOH HOH A . 
E 4 HOH 66  566 51  HOH HOH A . 
E 4 HOH 67  567 147 HOH HOH A . 
E 4 HOH 68  568 142 HOH HOH A . 
E 4 HOH 69  569 239 HOH HOH A . 
E 4 HOH 70  570 392 HOH HOH A . 
E 4 HOH 71  571 152 HOH HOH A . 
E 4 HOH 72  572 365 HOH HOH A . 
E 4 HOH 73  573 110 HOH HOH A . 
E 4 HOH 74  574 54  HOH HOH A . 
E 4 HOH 75  575 363 HOH HOH A . 
E 4 HOH 76  576 73  HOH HOH A . 
E 4 HOH 77  577 435 HOH HOH A . 
E 4 HOH 78  578 391 HOH HOH A . 
E 4 HOH 79  579 350 HOH HOH A . 
E 4 HOH 80  580 106 HOH HOH A . 
E 4 HOH 81  581 362 HOH HOH A . 
E 4 HOH 82  582 128 HOH HOH A . 
E 4 HOH 83  583 394 HOH HOH A . 
E 4 HOH 84  584 8   HOH HOH A . 
E 4 HOH 85  585 3   HOH HOH A . 
E 4 HOH 86  586 114 HOH HOH A . 
E 4 HOH 87  587 222 HOH HOH A . 
E 4 HOH 88  588 31  HOH HOH A . 
E 4 HOH 89  589 84  HOH HOH A . 
E 4 HOH 90  590 15  HOH HOH A . 
E 4 HOH 91  591 168 HOH HOH A . 
E 4 HOH 92  592 30  HOH HOH A . 
E 4 HOH 93  593 93  HOH HOH A . 
E 4 HOH 94  594 50  HOH HOH A . 
E 4 HOH 95  595 23  HOH HOH A . 
E 4 HOH 96  596 22  HOH HOH A . 
E 4 HOH 97  597 165 HOH HOH A . 
E 4 HOH 98  598 18  HOH HOH A . 
E 4 HOH 99  599 46  HOH HOH A . 
E 4 HOH 100 600 60  HOH HOH A . 
E 4 HOH 101 601 289 HOH HOH A . 
E 4 HOH 102 602 76  HOH HOH A . 
E 4 HOH 103 603 122 HOH HOH A . 
E 4 HOH 104 604 96  HOH HOH A . 
E 4 HOH 105 605 174 HOH HOH A . 
E 4 HOH 106 606 25  HOH HOH A . 
E 4 HOH 107 607 43  HOH HOH A . 
E 4 HOH 108 608 141 HOH HOH A . 
E 4 HOH 109 609 48  HOH HOH A . 
E 4 HOH 110 610 11  HOH HOH A . 
E 4 HOH 111 611 133 HOH HOH A . 
E 4 HOH 112 612 12  HOH HOH A . 
E 4 HOH 113 613 4   HOH HOH A . 
E 4 HOH 114 614 193 HOH HOH A . 
E 4 HOH 115 615 2   HOH HOH A . 
E 4 HOH 116 616 66  HOH HOH A . 
E 4 HOH 117 617 10  HOH HOH A . 
E 4 HOH 118 618 403 HOH HOH A . 
E 4 HOH 119 619 417 HOH HOH A . 
E 4 HOH 120 620 343 HOH HOH A . 
E 4 HOH 121 621 134 HOH HOH A . 
E 4 HOH 122 622 297 HOH HOH A . 
E 4 HOH 123 623 82  HOH HOH A . 
E 4 HOH 124 624 1   HOH HOH A . 
E 4 HOH 125 625 447 HOH HOH A . 
E 4 HOH 126 626 359 HOH HOH A . 
E 4 HOH 127 627 272 HOH HOH A . 
E 4 HOH 128 628 35  HOH HOH A . 
E 4 HOH 129 629 260 HOH HOH A . 
E 4 HOH 130 630 310 HOH HOH A . 
E 4 HOH 131 631 87  HOH HOH A . 
E 4 HOH 132 632 449 HOH HOH A . 
E 4 HOH 133 633 440 HOH HOH A . 
E 4 HOH 134 634 324 HOH HOH A . 
E 4 HOH 135 635 29  HOH HOH A . 
E 4 HOH 136 636 88  HOH HOH A . 
E 4 HOH 137 637 183 HOH HOH A . 
E 4 HOH 138 638 388 HOH HOH A . 
E 4 HOH 139 639 366 HOH HOH A . 
E 4 HOH 140 640 430 HOH HOH A . 
E 4 HOH 141 641 129 HOH HOH A . 
E 4 HOH 142 642 40  HOH HOH A . 
E 4 HOH 143 643 342 HOH HOH A . 
E 4 HOH 144 644 340 HOH HOH A . 
E 4 HOH 145 645 283 HOH HOH A . 
E 4 HOH 146 646 226 HOH HOH A . 
E 4 HOH 147 647 166 HOH HOH A . 
E 4 HOH 148 648 20  HOH HOH A . 
E 4 HOH 149 649 38  HOH HOH A . 
E 4 HOH 150 650 419 HOH HOH A . 
E 4 HOH 151 651 32  HOH HOH A . 
E 4 HOH 152 652 200 HOH HOH A . 
E 4 HOH 153 653 68  HOH HOH A . 
E 4 HOH 154 654 131 HOH HOH A . 
E 4 HOH 155 655 5   HOH HOH A . 
E 4 HOH 156 656 176 HOH HOH A . 
E 4 HOH 157 657 230 HOH HOH A . 
E 4 HOH 158 658 98  HOH HOH A . 
E 4 HOH 159 659 218 HOH HOH A . 
E 4 HOH 160 660 120 HOH HOH A . 
E 4 HOH 161 661 206 HOH HOH A . 
E 4 HOH 162 662 270 HOH HOH A . 
E 4 HOH 163 663 130 HOH HOH A . 
E 4 HOH 164 664 19  HOH HOH A . 
E 4 HOH 165 665 172 HOH HOH A . 
E 4 HOH 166 666 162 HOH HOH A . 
E 4 HOH 167 667 173 HOH HOH A . 
E 4 HOH 168 668 189 HOH HOH A . 
E 4 HOH 169 669 214 HOH HOH A . 
E 4 HOH 170 670 254 HOH HOH A . 
E 4 HOH 171 671 121 HOH HOH A . 
E 4 HOH 172 672 123 HOH HOH A . 
E 4 HOH 173 673 265 HOH HOH A . 
E 4 HOH 174 674 34  HOH HOH A . 
E 4 HOH 175 675 304 HOH HOH A . 
E 4 HOH 176 676 125 HOH HOH A . 
E 4 HOH 177 677 299 HOH HOH A . 
E 4 HOH 178 678 160 HOH HOH A . 
E 4 HOH 179 679 264 HOH HOH A . 
E 4 HOH 180 680 7   HOH HOH A . 
E 4 HOH 181 681 45  HOH HOH A . 
E 4 HOH 182 682 211 HOH HOH A . 
E 4 HOH 183 683 393 HOH HOH A . 
E 4 HOH 184 684 157 HOH HOH A . 
E 4 HOH 185 685 112 HOH HOH A . 
E 4 HOH 186 686 455 HOH HOH A . 
E 4 HOH 187 687 17  HOH HOH A . 
E 4 HOH 188 688 79  HOH HOH A . 
E 4 HOH 189 689 21  HOH HOH A . 
E 4 HOH 190 690 159 HOH HOH A . 
E 4 HOH 191 691 132 HOH HOH A . 
E 4 HOH 192 692 232 HOH HOH A . 
E 4 HOH 193 693 204 HOH HOH A . 
E 4 HOH 194 694 341 HOH HOH A . 
E 4 HOH 195 695 188 HOH HOH A . 
E 4 HOH 196 696 250 HOH HOH A . 
E 4 HOH 197 697 86  HOH HOH A . 
E 4 HOH 198 698 459 HOH HOH A . 
E 4 HOH 199 699 13  HOH HOH A . 
E 4 HOH 200 700 246 HOH HOH A . 
E 4 HOH 201 701 78  HOH HOH A . 
E 4 HOH 202 702 408 HOH HOH A . 
E 4 HOH 203 703 145 HOH HOH A . 
E 4 HOH 204 704 95  HOH HOH A . 
E 4 HOH 205 705 64  HOH HOH A . 
E 4 HOH 206 706 181 HOH HOH A . 
E 4 HOH 207 707 119 HOH HOH A . 
E 4 HOH 208 708 111 HOH HOH A . 
E 4 HOH 209 709 140 HOH HOH A . 
E 4 HOH 210 710 238 HOH HOH A . 
E 4 HOH 211 711 37  HOH HOH A . 
E 4 HOH 212 712 27  HOH HOH A . 
E 4 HOH 213 713 36  HOH HOH A . 
E 4 HOH 214 714 441 HOH HOH A . 
E 4 HOH 215 715 385 HOH HOH A . 
E 4 HOH 216 716 330 HOH HOH A . 
E 4 HOH 217 717 116 HOH HOH A . 
E 4 HOH 218 718 26  HOH HOH A . 
E 4 HOH 219 719 92  HOH HOH A . 
E 4 HOH 220 720 185 HOH HOH A . 
E 4 HOH 221 721 42  HOH HOH A . 
E 4 HOH 222 722 301 HOH HOH A . 
E 4 HOH 223 723 207 HOH HOH A . 
E 4 HOH 224 724 49  HOH HOH A . 
E 4 HOH 225 725 104 HOH HOH A . 
E 4 HOH 226 726 280 HOH HOH A . 
E 4 HOH 227 727 287 HOH HOH A . 
E 4 HOH 228 728 75  HOH HOH A . 
E 4 HOH 229 729 177 HOH HOH A . 
E 4 HOH 230 730 418 HOH HOH A . 
E 4 HOH 231 731 288 HOH HOH A . 
E 4 HOH 232 732 271 HOH HOH A . 
E 4 HOH 233 733 170 HOH HOH A . 
E 4 HOH 234 734 186 HOH HOH A . 
E 4 HOH 235 735 16  HOH HOH A . 
E 4 HOH 236 736 148 HOH HOH A . 
E 4 HOH 237 737 127 HOH HOH A . 
E 4 HOH 238 738 437 HOH HOH A . 
E 4 HOH 239 739 190 HOH HOH A . 
E 4 HOH 240 740 175 HOH HOH A . 
E 4 HOH 241 741 276 HOH HOH A . 
E 4 HOH 242 742 144 HOH HOH A . 
E 4 HOH 243 743 291 HOH HOH A . 
E 4 HOH 244 744 453 HOH HOH A . 
E 4 HOH 245 745 436 HOH HOH A . 
E 4 HOH 246 746 284 HOH HOH A . 
E 4 HOH 247 747 328 HOH HOH A . 
E 4 HOH 248 748 158 HOH HOH A . 
E 4 HOH 249 749 384 HOH HOH A . 
E 4 HOH 250 750 196 HOH HOH A . 
E 4 HOH 251 751 234 HOH HOH A . 
E 4 HOH 252 752 57  HOH HOH A . 
E 4 HOH 253 753 154 HOH HOH A . 
E 4 HOH 254 754 316 HOH HOH A . 
E 4 HOH 255 755 422 HOH HOH A . 
E 4 HOH 256 756 97  HOH HOH A . 
E 4 HOH 257 757 219 HOH HOH A . 
E 4 HOH 258 758 228 HOH HOH A . 
E 4 HOH 259 759 286 HOH HOH A . 
E 4 HOH 260 760 59  HOH HOH A . 
E 4 HOH 261 761 117 HOH HOH A . 
E 4 HOH 262 762 268 HOH HOH A . 
E 4 HOH 263 763 245 HOH HOH A . 
E 4 HOH 264 764 113 HOH HOH A . 
E 4 HOH 265 765 62  HOH HOH A . 
E 4 HOH 266 766 224 HOH HOH A . 
E 4 HOH 267 767 210 HOH HOH A . 
E 4 HOH 268 768 192 HOH HOH A . 
E 4 HOH 269 769 413 HOH HOH A . 
E 4 HOH 270 770 209 HOH HOH A . 
E 4 HOH 271 771 429 HOH HOH A . 
E 4 HOH 272 772 444 HOH HOH A . 
E 4 HOH 273 773 448 HOH HOH A . 
E 4 HOH 274 774 416 HOH HOH A . 
E 4 HOH 275 775 53  HOH HOH A . 
E 4 HOH 276 776 369 HOH HOH A . 
E 4 HOH 277 777 383 HOH HOH A . 
E 4 HOH 278 778 216 HOH HOH A . 
E 4 HOH 279 779 126 HOH HOH A . 
E 4 HOH 280 780 445 HOH HOH A . 
E 4 HOH 281 781 58  HOH HOH A . 
E 4 HOH 282 782 102 HOH HOH A . 
E 4 HOH 283 783 65  HOH HOH A . 
E 4 HOH 284 784 208 HOH HOH A . 
E 4 HOH 285 785 256 HOH HOH A . 
E 4 HOH 286 786 460 HOH HOH A . 
E 4 HOH 287 787 336 HOH HOH A . 
E 4 HOH 288 788 442 HOH HOH A . 
E 4 HOH 289 789 220 HOH HOH A . 
E 4 HOH 290 790 202 HOH HOH A . 
E 4 HOH 291 791 191 HOH HOH A . 
E 4 HOH 292 792 356 HOH HOH A . 
E 4 HOH 293 793 406 HOH HOH A . 
E 4 HOH 294 794 355 HOH HOH A . 
E 4 HOH 295 795 259 HOH HOH A . 
E 4 HOH 296 796 424 HOH HOH A . 
E 4 HOH 297 797 56  HOH HOH A . 
E 4 HOH 298 798 252 HOH HOH A . 
E 4 HOH 299 799 184 HOH HOH A . 
E 4 HOH 300 800 317 HOH HOH A . 
E 4 HOH 301 801 375 HOH HOH A . 
E 4 HOH 302 802 247 HOH HOH A . 
E 4 HOH 303 803 400 HOH HOH A . 
E 4 HOH 304 804 294 HOH HOH A . 
E 4 HOH 305 805 407 HOH HOH A . 
E 4 HOH 306 806 386 HOH HOH A . 
E 4 HOH 307 807 348 HOH HOH A . 
E 4 HOH 308 808 318 HOH HOH A . 
E 4 HOH 309 809 179 HOH HOH A . 
E 4 HOH 310 810 360 HOH HOH A . 
E 4 HOH 311 811 242 HOH HOH A . 
E 4 HOH 312 812 399 HOH HOH A . 
E 4 HOH 313 813 262 HOH HOH A . 
E 4 HOH 314 814 61  HOH HOH A . 
E 4 HOH 315 815 171 HOH HOH A . 
E 4 HOH 316 816 372 HOH HOH A . 
E 4 HOH 317 817 315 HOH HOH A . 
E 4 HOH 318 818 233 HOH HOH A . 
E 4 HOH 319 819 249 HOH HOH A . 
E 4 HOH 320 820 139 HOH HOH A . 
E 4 HOH 321 821 346 HOH HOH A . 
E 4 HOH 322 822 227 HOH HOH A . 
E 4 HOH 323 823 187 HOH HOH A . 
E 4 HOH 324 824 201 HOH HOH A . 
E 4 HOH 325 825 81  HOH HOH A . 
E 4 HOH 326 826 257 HOH HOH A . 
E 4 HOH 327 827 70  HOH HOH A . 
E 4 HOH 328 828 323 HOH HOH A . 
E 4 HOH 329 829 221 HOH HOH A . 
E 4 HOH 330 830 155 HOH HOH A . 
E 4 HOH 331 831 396 HOH HOH A . 
E 4 HOH 332 832 108 HOH HOH A . 
E 4 HOH 333 833 74  HOH HOH A . 
E 4 HOH 334 834 138 HOH HOH A . 
E 4 HOH 335 835 99  HOH HOH A . 
E 4 HOH 336 836 244 HOH HOH A . 
E 4 HOH 337 837 241 HOH HOH A . 
E 4 HOH 338 838 335 HOH HOH A . 
E 4 HOH 339 839 63  HOH HOH A . 
E 4 HOH 340 840 411 HOH HOH A . 
E 4 HOH 341 841 109 HOH HOH A . 
E 4 HOH 342 842 443 HOH HOH A . 
E 4 HOH 343 843 427 HOH HOH A . 
E 4 HOH 344 844 389 HOH HOH A . 
E 4 HOH 345 845 261 HOH HOH A . 
E 4 HOH 346 846 115 HOH HOH A . 
E 4 HOH 347 847 217 HOH HOH A . 
E 4 HOH 348 848 203 HOH HOH A . 
E 4 HOH 349 849 69  HOH HOH A . 
E 4 HOH 350 850 273 HOH HOH A . 
E 4 HOH 351 851 374 HOH HOH A . 
E 4 HOH 352 852 223 HOH HOH A . 
E 4 HOH 353 853 80  HOH HOH A . 
E 4 HOH 354 854 395 HOH HOH A . 
E 4 HOH 355 855 282 HOH HOH A . 
E 4 HOH 356 856 153 HOH HOH A . 
E 4 HOH 357 857 433 HOH HOH A . 
E 4 HOH 358 858 327 HOH HOH A . 
E 4 HOH 359 859 462 HOH HOH A . 
E 4 HOH 360 860 415 HOH HOH A . 
E 4 HOH 361 861 357 HOH HOH A . 
E 4 HOH 362 862 364 HOH HOH A . 
E 4 HOH 363 863 461 HOH HOH A . 
E 4 HOH 364 864 333 HOH HOH A . 
E 4 HOH 365 865 347 HOH HOH A . 
E 4 HOH 366 866 285 HOH HOH A . 
E 4 HOH 367 867 225 HOH HOH A . 
E 4 HOH 368 868 325 HOH HOH A . 
E 4 HOH 369 869 319 HOH HOH A . 
E 4 HOH 370 870 251 HOH HOH A . 
E 4 HOH 371 871 277 HOH HOH A . 
E 4 HOH 372 872 313 HOH HOH A . 
E 4 HOH 373 873 321 HOH HOH A . 
E 4 HOH 374 874 351 HOH HOH A . 
E 4 HOH 375 875 302 HOH HOH A . 
E 4 HOH 376 876 450 HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.20.1_4487 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? MOSFLM  ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? .           4 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? .           5 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   109.470 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8QR2 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     48.670 
_cell.length_a_esd                 ? 
_cell.length_b                     70.690 
_cell.length_b_esd                 ? 
_cell.length_c                     60.360 
_cell.length_c_esd                 ? 
_cell.volume                       195792.282 
_cell.volume_esd                   ? 
_cell.Z_PDB                        2 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8QR2 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                4 
_symmetry.space_group_name_Hall            'P 2yb' 
_symmetry.space_group_name_H-M             'P 1 21 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8QR2 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.31 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          46.84 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    'PEG MME 2000, 0.1M MES pH 6.5, 0.1M ammonium sulfate, 0.02M beta-mercaptoethanol' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            291.15 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     CCD 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'ADSC QUANTUM 315r' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2012-10-06 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.978002 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'ESRF BEAMLINE ID14-4' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.978002 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ID14-4 
_diffrn_source.pdbx_synchrotron_site       ESRF 
# 
_reflns.B_iso_Wilson_estimate                          19.38 
_reflns.entry_id                                       8QR2 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.64 
_reflns.d_resolution_low                               44.33 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     45095 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           95.7 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                3.9 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          23.0 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               0.81 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.040 
_reflns.pdbx_Rpim_I_all                                0.020 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       176520 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.035 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.64 
_reflns_shell.d_res_low                                     1.67 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           7911 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2154 
_reflns_shell.percent_possible_obs                          92.9 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               3.7 
_reflns_shell.pdbx_chi_squared                              0.70 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     4.9 
_reflns_shell.pdbx_Rrim_I_all                               0.241 
_reflns_shell.pdbx_Rpim_I_all                               0.122 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.960 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.207 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               28.91 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8QR2 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.64 
_refine.ls_d_res_low                             28.41 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     45070 
_refine.ls_number_reflns_R_free                  2099 
_refine.ls_number_reflns_R_work                  42971 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    95.34 
_refine.ls_percent_reflns_R_free                 4.66 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1312 
_refine.ls_R_factor_R_free                       0.1785 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1289 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.40 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 16.4696 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1270 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.64 
_refine_hist.d_res_low                        28.41 
_refine_hist.number_atoms_solvent             376 
_refine_hist.number_atoms_total               3198 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2786 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         36 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0129 ? 2988 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.3077 ? 4056 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0870 ? 450  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0114 ? 512  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 7.7033 ? 406  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.64 1.68  . . 132 2794 92.65 . . . . 0.1103 . . . . . . . . . . . 0.1871 
'X-RAY DIFFRACTION' 1.68 1.72  . . 138 2801 94.11 . . . . 0.1108 . . . . . . . . . . . 0.1752 
'X-RAY DIFFRACTION' 1.72 1.77  . . 128 2833 94.54 . . . . 0.1124 . . . . . . . . . . . 0.1885 
'X-RAY DIFFRACTION' 1.77 1.82  . . 140 2845 95.09 . . . . 0.1159 . . . . . . . . . . . 0.1723 
'X-RAY DIFFRACTION' 1.82 1.88  . . 132 2858 95.37 . . . . 0.1148 . . . . . . . . . . . 0.1674 
'X-RAY DIFFRACTION' 1.88 1.94  . . 162 2874 96.08 . . . . 0.1152 . . . . . . . . . . . 0.1854 
'X-RAY DIFFRACTION' 1.94 2.02  . . 142 2860 96.25 . . . . 0.1237 . . . . . . . . . . . 0.1806 
'X-RAY DIFFRACTION' 2.02 2.11  . . 133 2904 96.35 . . . . 0.1171 . . . . . . . . . . . 0.1704 
'X-RAY DIFFRACTION' 2.11 2.23  . . 153 2869 96.61 . . . . 0.1154 . . . . . . . . . . . 0.1777 
'X-RAY DIFFRACTION' 2.23 2.37  . . 146 2905 96.80 . . . . 0.1160 . . . . . . . . . . . 0.1646 
'X-RAY DIFFRACTION' 2.37 2.55  . . 156 2906 97.18 . . . . 0.1251 . . . . . . . . . . . 0.1656 
'X-RAY DIFFRACTION' 2.55 2.80  . . 143 2926 97.43 . . . . 0.1327 . . . . . . . . . . . 0.2050 
'X-RAY DIFFRACTION' 2.80 3.21  . . 130 2972 97.61 . . . . 0.1450 . . . . . . . . . . . 0.2058 
'X-RAY DIFFRACTION' 3.21 4.04  . . 133 2951 97.35 . . . . 0.1261 . . . . . . . . . . . 0.1735 
'X-RAY DIFFRACTION' 4.04 28.41 . . 131 2673 86.95 . . . . 0.1498 . . . . . . . . . . . 0.1658 
# 
_struct.entry_id                     8QR2 
_struct.title                        'Crystal structure of ERK2 in complex with a covalently bound macrocyclic ligand' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8QR2 
_struct_keywords.text            'SERINE-THREONINE-PROTEIN KINASE, SIGNALING PROTEIN' 
_struct_keywords.pdbx_keywords   'SIGNALING PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 3 ? 
E N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    MK01_RAT 
_struct_ref.pdbx_db_accession          P63086 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MAAAAAAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHEN
IIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCD
LKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG
ILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDE
PIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8QR2 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 7 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 364 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P63086 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  358 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       358 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 8QR2 HIS A 1 ? UNP P63086 ? ? 'expression tag' -5 1 
1 8QR2 HIS A 2 ? UNP P63086 ? ? 'expression tag' -4 2 
1 8QR2 HIS A 3 ? UNP P63086 ? ? 'expression tag' -3 3 
1 8QR2 HIS A 4 ? UNP P63086 ? ? 'expression tag' -2 4 
1 8QR2 HIS A 5 ? UNP P63086 ? ? 'expression tag' -1 5 
1 8QR2 HIS A 6 ? UNP P63086 ? ? 'expression tag' 0  6 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 350   ? 
1 MORE         -23   ? 
1 'SSA (A^2)'  16170 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   SAXS 
_pdbx_struct_assembly_auth_evidence.details                monomer 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 HIS A 65  ? PHE A 82  ? HIS A 59  PHE A 76  1 ? 18 
HELX_P HELX_P2  AA2 LEU A 116 ? GLN A 123 ? LEU A 110 GLN A 117 1 ? 8  
HELX_P HELX_P3  AA3 SER A 126 ? ALA A 147 ? SER A 120 ALA A 141 1 ? 22 
HELX_P HELX_P4  AA4 LYS A 155 ? SER A 157 ? LYS A 149 SER A 151 5 ? 3  
HELX_P HELX_P5  AA5 ASP A 179 ? ASP A 183 ? ASP A 173 ASP A 177 5 ? 5  
HELX_P HELX_P6  AA6 THR A 194 ? ARG A 198 ? THR A 188 ARG A 192 5 ? 5  
HELX_P HELX_P7  AA7 ALA A 199 ? ASN A 205 ? ALA A 193 ASN A 199 1 ? 7  
HELX_P HELX_P8  AA8 LYS A 211 ? ASN A 228 ? LYS A 205 ASN A 222 1 ? 18 
HELX_P HELX_P9  AA9 HIS A 236 ? GLY A 249 ? HIS A 230 GLY A 243 1 ? 14 
HELX_P HELX_P10 AB1 SER A 252 ? CME A 258 ? SER A 246 CME A 252 1 ? 7  
HELX_P HELX_P11 AB2 ASN A 261 ? SER A 270 ? ASN A 255 SER A 264 1 ? 10 
HELX_P HELX_P12 AB3 PRO A 278 ? PHE A 283 ? PRO A 272 PHE A 277 1 ? 6  
HELX_P HELX_P13 AB4 ASP A 287 ? LEU A 298 ? ASP A 281 LEU A 292 1 ? 12 
HELX_P HELX_P14 AB5 GLU A 307 ? ALA A 313 ? GLU A 301 ALA A 307 1 ? 7  
HELX_P HELX_P15 AB6 HIS A 314 ? GLU A 318 ? HIS A 308 GLU A 312 5 ? 5  
HELX_P HELX_P16 AB7 ASP A 322 ? GLU A 326 ? ASP A 316 GLU A 320 5 ? 5  
HELX_P HELX_P17 AB8 PRO A 343 ? THR A 355 ? PRO A 337 THR A 349 1 ? 13 
HELX_P HELX_P18 AB9 ALA A 356 ? GLN A 359 ? ALA A 350 GLN A 353 5 ? 4  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
covale1 covale both ? A THR 164 C  ? ? ? 1_555 A CME 165 N   ? ? A THR 158 A CME 159 1_555 ? ? ? ? ? ? ? 1.320 ? ? 
covale2 covale both ? A CME 165 C  ? ? ? 1_555 A ASP 166 N   ? ? A CME 159 A ASP 160 1_555 ? ? ? ? ? ? ? 1.333 ? ? 
covale3 covale none ? A CYS 170 SG ? ? ? 1_555 D WNT .   C14 ? ? A CYS 164 A WNT 403 1_555 ? ? ? ? ? ? ? 1.859 ? ? 
covale4 covale both ? A ASN 257 C  ? ? ? 1_555 A CME 258 N   ? ? A ASN 251 A CME 252 1_555 ? ? ? ? ? ? ? 1.330 ? ? 
covale5 covale both ? A CME 258 C  ? ? ? 1_555 A ILE 259 N   ? ? A CME 252 A ILE 253 1_555 ? ? ? ? ? ? ? 1.339 ? ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CME A 165 ? .   . .   . CME A 159 ? 1_555 .   . .   . .     .   .  CYS 1 CME Beta-mercaptoethanol 'Named protein modification' 
2 CME A 258 ? .   . .   . CME A 252 ? 1_555 .   . .   . .     .   .  CYS 1 CME Beta-mercaptoethanol 'Named protein modification' 
3 WNT D .   ? CYS A 170 ? WNT A 403 ? 1_555 CYS A 164 ? 1_555 C14 SG CYS 1 WNT None                 
'Covalent chemical modification' 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          GLY 
_struct_mon_prot_cis.label_seq_id           26 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           GLY 
_struct_mon_prot_cis.auth_seq_id            20 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    27 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     21 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       2.51 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 2 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
AA4 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA4 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 MET A 17  ? VAL A 18  ? MET A 11  VAL A 12  
AA1 2 GLN A 21  ? VAL A 22  ? GLN A 15  VAL A 16  
AA2 1 TYR A 29  ? GLY A 38  ? TYR A 23  GLY A 32  
AA2 2 GLY A 41  ? ASP A 48  ? GLY A 35  ASP A 42  
AA2 3 VAL A 53  ? ILE A 60  ? VAL A 47  ILE A 54  
AA2 4 VAL A 105 ? ASP A 110 ? VAL A 99  ASP A 104 
AA2 5 ASP A 92  ? ILE A 94  ? ASP A 86  ILE A 88  
AA3 1 THR A 114 ? ASP A 115 ? THR A 108 ASP A 109 
AA3 2 LEU A 159 ? LEU A 161 ? LEU A 153 LEU A 155 
AA3 3 LEU A 167 ? ILE A 169 ? LEU A 161 ILE A 163 
AA4 1 VAL A 149 ? LEU A 150 ? VAL A 143 LEU A 144 
AA4 2 ARG A 176 ? VAL A 177 ? ARG A 170 VAL A 171 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N VAL A 18  ? N VAL A 12  O GLN A 21  ? O GLN A 15  
AA2 1 2 N THR A 30  ? N THR A 24  O TYR A 47  ? O TYR A 41  
AA2 2 3 N ASP A 48  ? N ASP A 42  O VAL A 53  ? O VAL A 47  
AA2 3 4 N ALA A 56  ? N ALA A 50  O GLN A 109 ? O GLN A 103 
AA2 4 5 O VAL A 108 ? O VAL A 102 N ASP A 92  ? N ASP A 86  
AA3 1 2 N THR A 114 ? N THR A 108 O LEU A 161 ? O LEU A 155 
AA3 2 3 N LEU A 160 ? N LEU A 154 O LYS A 168 ? O LYS A 162 
AA4 1 2 N LEU A 150 ? N LEU A 144 O ARG A 176 ? O ARG A 170 
# 
_pdbx_entry_details.entry_id                   8QR2 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASN A 25  ? ? 60.96   64.76 
2 1 ASP A 147 ? ? -148.77 43.16 
3 1 ASP A 165 ? ? 74.31   96.40 
4 1 ASN A 199 ? ? -160.84 19.57 
5 1 LEU A 292 ? ? -96.50  48.85 
6 1 ASP A 316 ? ? -160.17 92.72 
7 1 ASP A 335 ? ? 65.65   -5.74 
# 
loop_
_pdbx_struct_mod_residue.id 
_pdbx_struct_mod_residue.label_asym_id 
_pdbx_struct_mod_residue.label_comp_id 
_pdbx_struct_mod_residue.label_seq_id 
_pdbx_struct_mod_residue.auth_asym_id 
_pdbx_struct_mod_residue.auth_comp_id 
_pdbx_struct_mod_residue.auth_seq_id 
_pdbx_struct_mod_residue.PDB_ins_code 
_pdbx_struct_mod_residue.parent_comp_id 
_pdbx_struct_mod_residue.details 
1 A CME 165 A CME 159 ? CYS 'modified residue' 
2 A CME 258 A CME 252 ? CYS 'modified residue' 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z       
2 -x,y+1/2,-z 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 874 ? 6.00 . 
2 1 O ? A HOH 875 ? 6.59 . 
3 1 O ? A HOH 876 ? 6.72 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A HIS -5  ? A HIS 1   
2  1 Y 1 A HIS -4  ? A HIS 2   
3  1 Y 1 A HIS -3  ? A HIS 3   
4  1 Y 1 A HIS -2  ? A HIS 4   
5  1 Y 1 A HIS -1  ? A HIS 5   
6  1 Y 1 A HIS 0   ? A HIS 6   
7  1 Y 1 A MET 1   ? A MET 7   
8  1 Y 1 A ALA 2   ? A ALA 8   
9  1 Y 1 A ALA 3   ? A ALA 9   
10 1 Y 1 A ALA 4   ? A ALA 10  
11 1 Y 1 A ALA 5   ? A ALA 11  
12 1 Y 1 A ALA 6   ? A ALA 12  
13 1 Y 1 A ALA 7   ? A ALA 13  
14 1 Y 1 A GLY 8   ? A GLY 14  
15 1 Y 1 A LYS 328 ? A LYS 334 
16 1 Y 1 A PHE 329 ? A PHE 335 
17 1 Y 1 A ASP 330 ? A ASP 336 
18 1 Y 1 A MET 331 ? A MET 337 
19 1 Y 1 A GLU 332 ? A GLU 338 
20 1 Y 1 A LEU 333 ? A LEU 339 
21 1 Y 1 A GLY 355 ? A GLY 361 
22 1 Y 1 A TYR 356 ? A TYR 362 
23 1 Y 1 A ARG 357 ? A ARG 363 
24 1 Y 1 A SER 358 ? A SER 364 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CME N    N N N 74  
CME CA   C N R 75  
CME CB   C N N 76  
CME SG   S N N 77  
CME SD   S N N 78  
CME CE   C N N 79  
CME CZ   C N N 80  
CME OH   O N N 81  
CME C    C N N 82  
CME O    O N N 83  
CME OXT  O N N 84  
CME H    H N N 85  
CME H2   H N N 86  
CME HA   H N N 87  
CME HB2  H N N 88  
CME HB3  H N N 89  
CME HE2  H N N 90  
CME HE3  H N N 91  
CME HZ2  H N N 92  
CME HZ3  H N N 93  
CME HH   H N N 94  
CME HXT  H N N 95  
CYS N    N N N 96  
CYS CA   C N R 97  
CYS C    C N N 98  
CYS O    O N N 99  
CYS CB   C N N 100 
CYS SG   S N N 101 
CYS OXT  O N N 102 
CYS H    H N N 103 
CYS H2   H N N 104 
CYS HA   H N N 105 
CYS HB2  H N N 106 
CYS HB3  H N N 107 
CYS HG   H N N 108 
CYS HXT  H N N 109 
GLN N    N N N 110 
GLN CA   C N S 111 
GLN C    C N N 112 
GLN O    O N N 113 
GLN CB   C N N 114 
GLN CG   C N N 115 
GLN CD   C N N 116 
GLN OE1  O N N 117 
GLN NE2  N N N 118 
GLN OXT  O N N 119 
GLN H    H N N 120 
GLN H2   H N N 121 
GLN HA   H N N 122 
GLN HB2  H N N 123 
GLN HB3  H N N 124 
GLN HG2  H N N 125 
GLN HG3  H N N 126 
GLN HE21 H N N 127 
GLN HE22 H N N 128 
GLN HXT  H N N 129 
GLU N    N N N 130 
GLU CA   C N S 131 
GLU C    C N N 132 
GLU O    O N N 133 
GLU CB   C N N 134 
GLU CG   C N N 135 
GLU CD   C N N 136 
GLU OE1  O N N 137 
GLU OE2  O N N 138 
GLU OXT  O N N 139 
GLU H    H N N 140 
GLU H2   H N N 141 
GLU HA   H N N 142 
GLU HB2  H N N 143 
GLU HB3  H N N 144 
GLU HG2  H N N 145 
GLU HG3  H N N 146 
GLU HE2  H N N 147 
GLU HXT  H N N 148 
GLY N    N N N 149 
GLY CA   C N N 150 
GLY C    C N N 151 
GLY O    O N N 152 
GLY OXT  O N N 153 
GLY H    H N N 154 
GLY H2   H N N 155 
GLY HA2  H N N 156 
GLY HA3  H N N 157 
GLY HXT  H N N 158 
HIS N    N N N 159 
HIS CA   C N S 160 
HIS C    C N N 161 
HIS O    O N N 162 
HIS CB   C N N 163 
HIS CG   C Y N 164 
HIS ND1  N Y N 165 
HIS CD2  C Y N 166 
HIS CE1  C Y N 167 
HIS NE2  N Y N 168 
HIS OXT  O N N 169 
HIS H    H N N 170 
HIS H2   H N N 171 
HIS HA   H N N 172 
HIS HB2  H N N 173 
HIS HB3  H N N 174 
HIS HD1  H N N 175 
HIS HD2  H N N 176 
HIS HE1  H N N 177 
HIS HE2  H N N 178 
HIS HXT  H N N 179 
HOH O    O N N 180 
HOH H1   H N N 181 
HOH H2   H N N 182 
ILE N    N N N 183 
ILE CA   C N S 184 
ILE C    C N N 185 
ILE O    O N N 186 
ILE CB   C N S 187 
ILE CG1  C N N 188 
ILE CG2  C N N 189 
ILE CD1  C N N 190 
ILE OXT  O N N 191 
ILE H    H N N 192 
ILE H2   H N N 193 
ILE HA   H N N 194 
ILE HB   H N N 195 
ILE HG12 H N N 196 
ILE HG13 H N N 197 
ILE HG21 H N N 198 
ILE HG22 H N N 199 
ILE HG23 H N N 200 
ILE HD11 H N N 201 
ILE HD12 H N N 202 
ILE HD13 H N N 203 
ILE HXT  H N N 204 
LEU N    N N N 205 
LEU CA   C N S 206 
LEU C    C N N 207 
LEU O    O N N 208 
LEU CB   C N N 209 
LEU CG   C N N 210 
LEU CD1  C N N 211 
LEU CD2  C N N 212 
LEU OXT  O N N 213 
LEU H    H N N 214 
LEU H2   H N N 215 
LEU HA   H N N 216 
LEU HB2  H N N 217 
LEU HB3  H N N 218 
LEU HG   H N N 219 
LEU HD11 H N N 220 
LEU HD12 H N N 221 
LEU HD13 H N N 222 
LEU HD21 H N N 223 
LEU HD22 H N N 224 
LEU HD23 H N N 225 
LEU HXT  H N N 226 
LYS N    N N N 227 
LYS CA   C N S 228 
LYS C    C N N 229 
LYS O    O N N 230 
LYS CB   C N N 231 
LYS CG   C N N 232 
LYS CD   C N N 233 
LYS CE   C N N 234 
LYS NZ   N N N 235 
LYS OXT  O N N 236 
LYS H    H N N 237 
LYS H2   H N N 238 
LYS HA   H N N 239 
LYS HB2  H N N 240 
LYS HB3  H N N 241 
LYS HG2  H N N 242 
LYS HG3  H N N 243 
LYS HD2  H N N 244 
LYS HD3  H N N 245 
LYS HE2  H N N 246 
LYS HE3  H N N 247 
LYS HZ1  H N N 248 
LYS HZ2  H N N 249 
LYS HZ3  H N N 250 
LYS HXT  H N N 251 
MET N    N N N 252 
MET CA   C N S 253 
MET C    C N N 254 
MET O    O N N 255 
MET CB   C N N 256 
MET CG   C N N 257 
MET SD   S N N 258 
MET CE   C N N 259 
MET OXT  O N N 260 
MET H    H N N 261 
MET H2   H N N 262 
MET HA   H N N 263 
MET HB2  H N N 264 
MET HB3  H N N 265 
MET HG2  H N N 266 
MET HG3  H N N 267 
MET HE1  H N N 268 
MET HE2  H N N 269 
MET HE3  H N N 270 
MET HXT  H N N 271 
PHE N    N N N 272 
PHE CA   C N S 273 
PHE C    C N N 274 
PHE O    O N N 275 
PHE CB   C N N 276 
PHE CG   C Y N 277 
PHE CD1  C Y N 278 
PHE CD2  C Y N 279 
PHE CE1  C Y N 280 
PHE CE2  C Y N 281 
PHE CZ   C Y N 282 
PHE OXT  O N N 283 
PHE H    H N N 284 
PHE H2   H N N 285 
PHE HA   H N N 286 
PHE HB2  H N N 287 
PHE HB3  H N N 288 
PHE HD1  H N N 289 
PHE HD2  H N N 290 
PHE HE1  H N N 291 
PHE HE2  H N N 292 
PHE HZ   H N N 293 
PHE HXT  H N N 294 
PRO N    N N N 295 
PRO CA   C N S 296 
PRO C    C N N 297 
PRO O    O N N 298 
PRO CB   C N N 299 
PRO CG   C N N 300 
PRO CD   C N N 301 
PRO OXT  O N N 302 
PRO H    H N N 303 
PRO HA   H N N 304 
PRO HB2  H N N 305 
PRO HB3  H N N 306 
PRO HG2  H N N 307 
PRO HG3  H N N 308 
PRO HD2  H N N 309 
PRO HD3  H N N 310 
PRO HXT  H N N 311 
SER N    N N N 312 
SER CA   C N S 313 
SER C    C N N 314 
SER O    O N N 315 
SER CB   C N N 316 
SER OG   O N N 317 
SER OXT  O N N 318 
SER H    H N N 319 
SER H2   H N N 320 
SER HA   H N N 321 
SER HB2  H N N 322 
SER HB3  H N N 323 
SER HG   H N N 324 
SER HXT  H N N 325 
SO4 S    S N N 326 
SO4 O1   O N N 327 
SO4 O2   O N N 328 
SO4 O3   O N N 329 
SO4 O4   O N N 330 
THR N    N N N 331 
THR CA   C N S 332 
THR C    C N N 333 
THR O    O N N 334 
THR CB   C N R 335 
THR OG1  O N N 336 
THR CG2  C N N 337 
THR OXT  O N N 338 
THR H    H N N 339 
THR H2   H N N 340 
THR HA   H N N 341 
THR HB   H N N 342 
THR HG1  H N N 343 
THR HG21 H N N 344 
THR HG22 H N N 345 
THR HG23 H N N 346 
THR HXT  H N N 347 
TRP N    N N N 348 
TRP CA   C N S 349 
TRP C    C N N 350 
TRP O    O N N 351 
TRP CB   C N N 352 
TRP CG   C Y N 353 
TRP CD1  C Y N 354 
TRP CD2  C Y N 355 
TRP NE1  N Y N 356 
TRP CE2  C Y N 357 
TRP CE3  C Y N 358 
TRP CZ2  C Y N 359 
TRP CZ3  C Y N 360 
TRP CH2  C Y N 361 
TRP OXT  O N N 362 
TRP H    H N N 363 
TRP H2   H N N 364 
TRP HA   H N N 365 
TRP HB2  H N N 366 
TRP HB3  H N N 367 
TRP HD1  H N N 368 
TRP HE1  H N N 369 
TRP HE3  H N N 370 
TRP HZ2  H N N 371 
TRP HZ3  H N N 372 
TRP HH2  H N N 373 
TRP HXT  H N N 374 
TYR N    N N N 375 
TYR CA   C N S 376 
TYR C    C N N 377 
TYR O    O N N 378 
TYR CB   C N N 379 
TYR CG   C Y N 380 
TYR CD1  C Y N 381 
TYR CD2  C Y N 382 
TYR CE1  C Y N 383 
TYR CE2  C Y N 384 
TYR CZ   C Y N 385 
TYR OH   O N N 386 
TYR OXT  O N N 387 
TYR H    H N N 388 
TYR H2   H N N 389 
TYR HA   H N N 390 
TYR HB2  H N N 391 
TYR HB3  H N N 392 
TYR HD1  H N N 393 
TYR HD2  H N N 394 
TYR HE1  H N N 395 
TYR HE2  H N N 396 
TYR HH   H N N 397 
TYR HXT  H N N 398 
VAL N    N N N 399 
VAL CA   C N S 400 
VAL C    C N N 401 
VAL O    O N N 402 
VAL CB   C N N 403 
VAL CG1  C N N 404 
VAL CG2  C N N 405 
VAL OXT  O N N 406 
VAL H    H N N 407 
VAL H2   H N N 408 
VAL HA   H N N 409 
VAL HB   H N N 410 
VAL HG11 H N N 411 
VAL HG12 H N N 412 
VAL HG13 H N N 413 
VAL HG21 H N N 414 
VAL HG22 H N N 415 
VAL HG23 H N N 416 
VAL HXT  H N N 417 
WNT C3   C Y N 418 
WNT C5   C Y N 419 
WNT C6   C Y N 420 
WNT C9   C N N 421 
WNT C10  C N S 422 
WNT C11  C N S 423 
WNT C8   C N N 424 
WNT C2   C Y N 425 
WNT C7   C N N 426 
WNT C16  C N S 427 
WNT C15  C N N 428 
WNT C13  C N N 429 
WNT C12  C N N 430 
WNT C18  C N N 431 
WNT C17  C N N 432 
WNT C    C N N 433 
WNT O    O N N 434 
WNT C1   C Y N 435 
WNT C14  C N N 436 
WNT C4   C Y N 437 
WNT O1   O N N 438 
WNT O2   O N N 439 
WNT O3   O N N 440 
WNT O4   O N N 441 
WNT O5   O N N 442 
WNT O6   O N N 443 
WNT H8   H N N 444 
WNT H11  H N N 445 
WNT H12  H N N 446 
WNT H    H N N 447 
WNT H1   H N N 448 
WNT H10  H N N 449 
WNT H6   H N N 450 
WNT H9   H N N 451 
WNT H2   H N N 452 
WNT H18  H N N 453 
WNT H17  H N N 454 
WNT H15  H N N 455 
WNT H131 H N N 456 
WNT H21  H N N 457 
WNT H20  H N N 458 
WNT H19  H N N 459 
WNT H5   H N N 460 
WNT H4   H N N 461 
WNT H3   H N N 462 
WNT H16  H N N 463 
WNT H141 H N N 464 
WNT H7   H N N 465 
WNT H13  H N N 466 
WNT H14  H N N 467 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CME N   CA   sing N N 70  
CME N   H    sing N N 71  
CME N   H2   sing N N 72  
CME CA  CB   sing N N 73  
CME CA  C    sing N N 74  
CME CA  HA   sing N N 75  
CME CB  SG   sing N N 76  
CME CB  HB2  sing N N 77  
CME CB  HB3  sing N N 78  
CME SG  SD   sing N N 79  
CME SD  CE   sing N N 80  
CME CE  CZ   sing N N 81  
CME CE  HE2  sing N N 82  
CME CE  HE3  sing N N 83  
CME CZ  OH   sing N N 84  
CME CZ  HZ2  sing N N 85  
CME CZ  HZ3  sing N N 86  
CME OH  HH   sing N N 87  
CME C   O    doub N N 88  
CME C   OXT  sing N N 89  
CME OXT HXT  sing N N 90  
CYS N   CA   sing N N 91  
CYS N   H    sing N N 92  
CYS N   H2   sing N N 93  
CYS CA  C    sing N N 94  
CYS CA  CB   sing N N 95  
CYS CA  HA   sing N N 96  
CYS C   O    doub N N 97  
CYS C   OXT  sing N N 98  
CYS CB  SG   sing N N 99  
CYS CB  HB2  sing N N 100 
CYS CB  HB3  sing N N 101 
CYS SG  HG   sing N N 102 
CYS OXT HXT  sing N N 103 
GLN N   CA   sing N N 104 
GLN N   H    sing N N 105 
GLN N   H2   sing N N 106 
GLN CA  C    sing N N 107 
GLN CA  CB   sing N N 108 
GLN CA  HA   sing N N 109 
GLN C   O    doub N N 110 
GLN C   OXT  sing N N 111 
GLN CB  CG   sing N N 112 
GLN CB  HB2  sing N N 113 
GLN CB  HB3  sing N N 114 
GLN CG  CD   sing N N 115 
GLN CG  HG2  sing N N 116 
GLN CG  HG3  sing N N 117 
GLN CD  OE1  doub N N 118 
GLN CD  NE2  sing N N 119 
GLN NE2 HE21 sing N N 120 
GLN NE2 HE22 sing N N 121 
GLN OXT HXT  sing N N 122 
GLU N   CA   sing N N 123 
GLU N   H    sing N N 124 
GLU N   H2   sing N N 125 
GLU CA  C    sing N N 126 
GLU CA  CB   sing N N 127 
GLU CA  HA   sing N N 128 
GLU C   O    doub N N 129 
GLU C   OXT  sing N N 130 
GLU CB  CG   sing N N 131 
GLU CB  HB2  sing N N 132 
GLU CB  HB3  sing N N 133 
GLU CG  CD   sing N N 134 
GLU CG  HG2  sing N N 135 
GLU CG  HG3  sing N N 136 
GLU CD  OE1  doub N N 137 
GLU CD  OE2  sing N N 138 
GLU OE2 HE2  sing N N 139 
GLU OXT HXT  sing N N 140 
GLY N   CA   sing N N 141 
GLY N   H    sing N N 142 
GLY N   H2   sing N N 143 
GLY CA  C    sing N N 144 
GLY CA  HA2  sing N N 145 
GLY CA  HA3  sing N N 146 
GLY C   O    doub N N 147 
GLY C   OXT  sing N N 148 
GLY OXT HXT  sing N N 149 
HIS N   CA   sing N N 150 
HIS N   H    sing N N 151 
HIS N   H2   sing N N 152 
HIS CA  C    sing N N 153 
HIS CA  CB   sing N N 154 
HIS CA  HA   sing N N 155 
HIS C   O    doub N N 156 
HIS C   OXT  sing N N 157 
HIS CB  CG   sing N N 158 
HIS CB  HB2  sing N N 159 
HIS CB  HB3  sing N N 160 
HIS CG  ND1  sing Y N 161 
HIS CG  CD2  doub Y N 162 
HIS ND1 CE1  doub Y N 163 
HIS ND1 HD1  sing N N 164 
HIS CD2 NE2  sing Y N 165 
HIS CD2 HD2  sing N N 166 
HIS CE1 NE2  sing Y N 167 
HIS CE1 HE1  sing N N 168 
HIS NE2 HE2  sing N N 169 
HIS OXT HXT  sing N N 170 
HOH O   H1   sing N N 171 
HOH O   H2   sing N N 172 
ILE N   CA   sing N N 173 
ILE N   H    sing N N 174 
ILE N   H2   sing N N 175 
ILE CA  C    sing N N 176 
ILE CA  CB   sing N N 177 
ILE CA  HA   sing N N 178 
ILE C   O    doub N N 179 
ILE C   OXT  sing N N 180 
ILE CB  CG1  sing N N 181 
ILE CB  CG2  sing N N 182 
ILE CB  HB   sing N N 183 
ILE CG1 CD1  sing N N 184 
ILE CG1 HG12 sing N N 185 
ILE CG1 HG13 sing N N 186 
ILE CG2 HG21 sing N N 187 
ILE CG2 HG22 sing N N 188 
ILE CG2 HG23 sing N N 189 
ILE CD1 HD11 sing N N 190 
ILE CD1 HD12 sing N N 191 
ILE CD1 HD13 sing N N 192 
ILE OXT HXT  sing N N 193 
LEU N   CA   sing N N 194 
LEU N   H    sing N N 195 
LEU N   H2   sing N N 196 
LEU CA  C    sing N N 197 
LEU CA  CB   sing N N 198 
LEU CA  HA   sing N N 199 
LEU C   O    doub N N 200 
LEU C   OXT  sing N N 201 
LEU CB  CG   sing N N 202 
LEU CB  HB2  sing N N 203 
LEU CB  HB3  sing N N 204 
LEU CG  CD1  sing N N 205 
LEU CG  CD2  sing N N 206 
LEU CG  HG   sing N N 207 
LEU CD1 HD11 sing N N 208 
LEU CD1 HD12 sing N N 209 
LEU CD1 HD13 sing N N 210 
LEU CD2 HD21 sing N N 211 
LEU CD2 HD22 sing N N 212 
LEU CD2 HD23 sing N N 213 
LEU OXT HXT  sing N N 214 
LYS N   CA   sing N N 215 
LYS N   H    sing N N 216 
LYS N   H2   sing N N 217 
LYS CA  C    sing N N 218 
LYS CA  CB   sing N N 219 
LYS CA  HA   sing N N 220 
LYS C   O    doub N N 221 
LYS C   OXT  sing N N 222 
LYS CB  CG   sing N N 223 
LYS CB  HB2  sing N N 224 
LYS CB  HB3  sing N N 225 
LYS CG  CD   sing N N 226 
LYS CG  HG2  sing N N 227 
LYS CG  HG3  sing N N 228 
LYS CD  CE   sing N N 229 
LYS CD  HD2  sing N N 230 
LYS CD  HD3  sing N N 231 
LYS CE  NZ   sing N N 232 
LYS CE  HE2  sing N N 233 
LYS CE  HE3  sing N N 234 
LYS NZ  HZ1  sing N N 235 
LYS NZ  HZ2  sing N N 236 
LYS NZ  HZ3  sing N N 237 
LYS OXT HXT  sing N N 238 
MET N   CA   sing N N 239 
MET N   H    sing N N 240 
MET N   H2   sing N N 241 
MET CA  C    sing N N 242 
MET CA  CB   sing N N 243 
MET CA  HA   sing N N 244 
MET C   O    doub N N 245 
MET C   OXT  sing N N 246 
MET CB  CG   sing N N 247 
MET CB  HB2  sing N N 248 
MET CB  HB3  sing N N 249 
MET CG  SD   sing N N 250 
MET CG  HG2  sing N N 251 
MET CG  HG3  sing N N 252 
MET SD  CE   sing N N 253 
MET CE  HE1  sing N N 254 
MET CE  HE2  sing N N 255 
MET CE  HE3  sing N N 256 
MET OXT HXT  sing N N 257 
PHE N   CA   sing N N 258 
PHE N   H    sing N N 259 
PHE N   H2   sing N N 260 
PHE CA  C    sing N N 261 
PHE CA  CB   sing N N 262 
PHE CA  HA   sing N N 263 
PHE C   O    doub N N 264 
PHE C   OXT  sing N N 265 
PHE CB  CG   sing N N 266 
PHE CB  HB2  sing N N 267 
PHE CB  HB3  sing N N 268 
PHE CG  CD1  doub Y N 269 
PHE CG  CD2  sing Y N 270 
PHE CD1 CE1  sing Y N 271 
PHE CD1 HD1  sing N N 272 
PHE CD2 CE2  doub Y N 273 
PHE CD2 HD2  sing N N 274 
PHE CE1 CZ   doub Y N 275 
PHE CE1 HE1  sing N N 276 
PHE CE2 CZ   sing Y N 277 
PHE CE2 HE2  sing N N 278 
PHE CZ  HZ   sing N N 279 
PHE OXT HXT  sing N N 280 
PRO N   CA   sing N N 281 
PRO N   CD   sing N N 282 
PRO N   H    sing N N 283 
PRO CA  C    sing N N 284 
PRO CA  CB   sing N N 285 
PRO CA  HA   sing N N 286 
PRO C   O    doub N N 287 
PRO C   OXT  sing N N 288 
PRO CB  CG   sing N N 289 
PRO CB  HB2  sing N N 290 
PRO CB  HB3  sing N N 291 
PRO CG  CD   sing N N 292 
PRO CG  HG2  sing N N 293 
PRO CG  HG3  sing N N 294 
PRO CD  HD2  sing N N 295 
PRO CD  HD3  sing N N 296 
PRO OXT HXT  sing N N 297 
SER N   CA   sing N N 298 
SER N   H    sing N N 299 
SER N   H2   sing N N 300 
SER CA  C    sing N N 301 
SER CA  CB   sing N N 302 
SER CA  HA   sing N N 303 
SER C   O    doub N N 304 
SER C   OXT  sing N N 305 
SER CB  OG   sing N N 306 
SER CB  HB2  sing N N 307 
SER CB  HB3  sing N N 308 
SER OG  HG   sing N N 309 
SER OXT HXT  sing N N 310 
SO4 S   O1   doub N N 311 
SO4 S   O2   doub N N 312 
SO4 S   O3   sing N N 313 
SO4 S   O4   sing N N 314 
THR N   CA   sing N N 315 
THR N   H    sing N N 316 
THR N   H2   sing N N 317 
THR CA  C    sing N N 318 
THR CA  CB   sing N N 319 
THR CA  HA   sing N N 320 
THR C   O    doub N N 321 
THR C   OXT  sing N N 322 
THR CB  OG1  sing N N 323 
THR CB  CG2  sing N N 324 
THR CB  HB   sing N N 325 
THR OG1 HG1  sing N N 326 
THR CG2 HG21 sing N N 327 
THR CG2 HG22 sing N N 328 
THR CG2 HG23 sing N N 329 
THR OXT HXT  sing N N 330 
TRP N   CA   sing N N 331 
TRP N   H    sing N N 332 
TRP N   H2   sing N N 333 
TRP CA  C    sing N N 334 
TRP CA  CB   sing N N 335 
TRP CA  HA   sing N N 336 
TRP C   O    doub N N 337 
TRP C   OXT  sing N N 338 
TRP CB  CG   sing N N 339 
TRP CB  HB2  sing N N 340 
TRP CB  HB3  sing N N 341 
TRP CG  CD1  doub Y N 342 
TRP CG  CD2  sing Y N 343 
TRP CD1 NE1  sing Y N 344 
TRP CD1 HD1  sing N N 345 
TRP CD2 CE2  doub Y N 346 
TRP CD2 CE3  sing Y N 347 
TRP NE1 CE2  sing Y N 348 
TRP NE1 HE1  sing N N 349 
TRP CE2 CZ2  sing Y N 350 
TRP CE3 CZ3  doub Y N 351 
TRP CE3 HE3  sing N N 352 
TRP CZ2 CH2  doub Y N 353 
TRP CZ2 HZ2  sing N N 354 
TRP CZ3 CH2  sing Y N 355 
TRP CZ3 HZ3  sing N N 356 
TRP CH2 HH2  sing N N 357 
TRP OXT HXT  sing N N 358 
TYR N   CA   sing N N 359 
TYR N   H    sing N N 360 
TYR N   H2   sing N N 361 
TYR CA  C    sing N N 362 
TYR CA  CB   sing N N 363 
TYR CA  HA   sing N N 364 
TYR C   O    doub N N 365 
TYR C   OXT  sing N N 366 
TYR CB  CG   sing N N 367 
TYR CB  HB2  sing N N 368 
TYR CB  HB3  sing N N 369 
TYR CG  CD1  doub Y N 370 
TYR CG  CD2  sing Y N 371 
TYR CD1 CE1  sing Y N 372 
TYR CD1 HD1  sing N N 373 
TYR CD2 CE2  doub Y N 374 
TYR CD2 HD2  sing N N 375 
TYR CE1 CZ   doub Y N 376 
TYR CE1 HE1  sing N N 377 
TYR CE2 CZ   sing Y N 378 
TYR CE2 HE2  sing N N 379 
TYR CZ  OH   sing N N 380 
TYR OH  HH   sing N N 381 
TYR OXT HXT  sing N N 382 
VAL N   CA   sing N N 383 
VAL N   H    sing N N 384 
VAL N   H2   sing N N 385 
VAL CA  C    sing N N 386 
VAL CA  CB   sing N N 387 
VAL CA  HA   sing N N 388 
VAL C   O    doub N N 389 
VAL C   OXT  sing N N 390 
VAL CB  CG1  sing N N 391 
VAL CB  CG2  sing N N 392 
VAL CB  HB   sing N N 393 
VAL CG1 HG11 sing N N 394 
VAL CG1 HG12 sing N N 395 
VAL CG1 HG13 sing N N 396 
VAL CG2 HG21 sing N N 397 
VAL CG2 HG22 sing N N 398 
VAL CG2 HG23 sing N N 399 
VAL OXT HXT  sing N N 400 
WNT O6  C18  doub N N 401 
WNT C18 C4   sing N N 402 
WNT C18 O5   sing N N 403 
WNT C4  C3   doub Y N 404 
WNT C4  C5   sing Y N 405 
WNT C3  O1   sing N N 406 
WNT C3  C2   sing Y N 407 
WNT C2  C1   doub Y N 408 
WNT O5  C16  sing N N 409 
WNT C16 C17  sing N N 410 
WNT C16 C15  sing N N 411 
WNT C15 C14  sing N N 412 
WNT C14 C13  sing N N 413 
WNT C13 C12  sing N N 414 
WNT C12 O4   doub N N 415 
WNT C12 C11  sing N N 416 
WNT C11 O3   sing N N 417 
WNT C11 C10  sing N N 418 
WNT C10 O2   sing N N 419 
WNT C10 C9   sing N N 420 
WNT C9  C8   sing N N 421 
WNT C8  C7   doub N E 422 
WNT C7  C5   sing N N 423 
WNT C5  C6   doub Y N 424 
WNT C6  C1   sing Y N 425 
WNT C1  O    sing N N 426 
WNT O   C    sing N N 427 
WNT C6  H8   sing N N 428 
WNT C9  H11  sing N N 429 
WNT C9  H12  sing N N 430 
WNT C10 H    sing N N 431 
WNT C11 H1   sing N N 432 
WNT C8  H10  sing N N 433 
WNT C2  H6   sing N N 434 
WNT C7  H9   sing N N 435 
WNT C16 H2   sing N N 436 
WNT C15 H18  sing N N 437 
WNT C15 H17  sing N N 438 
WNT C13 H15  sing N N 439 
WNT C13 H131 sing N N 440 
WNT C17 H21  sing N N 441 
WNT C17 H20  sing N N 442 
WNT C17 H19  sing N N 443 
WNT C   H5   sing N N 444 
WNT C   H4   sing N N 445 
WNT C   H3   sing N N 446 
WNT C14 H16  sing N N 447 
WNT C14 H141 sing N N 448 
WNT O1  H7   sing N N 449 
WNT O2  H13  sing N N 450 
WNT O3  H14  sing N N 451 
# 
_pdbx_audit_support.funding_organization   'Agence Nationale de la Recherche (ANR)' 
_pdbx_audit_support.country                France 
_pdbx_audit_support.grant_number           ANR-20-CE18-0025 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   3QYZ 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 1 21 1' 
_space_group.name_Hall        'P 2yb' 
_space_group.IT_number        4 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    8QR2 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.020547 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.007264 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.014146 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.017572 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . PRO A 1 15  ? -21.28051 21.95093  20.45089 1.000 63.31216 ? 9   PRO A N   1 
ATOM   2    C CA  . PRO A 1 15  ? -21.14154 21.21555  21.71063 1.000 63.06472 ? 9   PRO A CA  1 
ATOM   3    C C   . PRO A 1 15  ? -21.84232 21.89742  22.88454 1.000 62.73109 ? 9   PRO A C   1 
ATOM   4    O O   . PRO A 1 15  ? -22.08008 23.09505  22.82079 1.000 62.05539 ? 9   PRO A O   1 
ATOM   5    C CB  . PRO A 1 15  ? -19.61958 21.19803  21.93365 1.000 63.62779 ? 9   PRO A CB  1 
ATOM   6    C CG  . PRO A 1 15  ? -19.05148 22.17708  20.90569 1.000 63.59209 ? 9   PRO A CG  1 
ATOM   7    C CD  . PRO A 1 15  ? -19.98494 22.05258  19.76349 1.000 63.40264 ? 9   PRO A CD  1 
ATOM   8    N N   . GLU A 1 16  ? -22.16415 21.15437  23.94375 1.000 63.35337 ? 10  GLU A N   1 
ATOM   9    C CA  . GLU A 1 16  ? -22.66692 21.78967  25.15863 1.000 63.34592 ? 10  GLU A CA  1 
ATOM   10   C C   . GLU A 1 16  ? -21.50268 22.50162  25.84533 1.000 63.09290 ? 10  GLU A C   1 
ATOM   11   O O   . GLU A 1 16  ? -20.35369 22.05693  25.77460 1.000 62.92191 ? 10  GLU A O   1 
ATOM   12   C CB  . GLU A 1 16  ? -23.32818 20.75093  26.09124 1.000 63.97897 ? 10  GLU A CB  1 
ATOM   13   C CG  . GLU A 1 16  ? -24.56216 21.27966  26.91466 1.000 63.68632 ? 10  GLU A CG  1 
ATOM   14   C CD  . GLU A 1 16  ? -25.45484 20.16875  27.57802 1.000 63.28693 ? 10  GLU A CD  1 
ATOM   15   O OE1 . GLU A 1 16  ? -25.80963 19.14740  26.92474 1.000 62.72693 ? 10  GLU A OE1 1 
ATOM   16   O OE2 . GLU A 1 16  ? -25.80598 20.32550  28.78229 1.000 61.97272 ? 10  GLU A OE2 1 
ATOM   17   N N   . MET A 1 17  ? -21.77568 23.64717  26.45544 1.000 62.83090 ? 11  MET A N   1 
ATOM   18   C CA  . MET A 1 17  ? -20.71190 24.44835  27.04408 1.000 62.52711 ? 11  MET A CA  1 
ATOM   19   C C   . MET A 1 17  ? -20.98954 24.67103  28.52097 1.000 60.76483 ? 11  MET A C   1 
ATOM   20   O O   . MET A 1 17  ? -22.14687 24.75917  28.93845 1.000 60.45374 ? 11  MET A O   1 
ATOM   21   C CB  . MET A 1 17  ? -20.53651 25.79577  26.31438 1.000 63.64893 ? 11  MET A CB  1 
ATOM   22   C CG  . MET A 1 17  ? -20.59756 25.70676  24.77916 1.000 64.96132 ? 11  MET A CG  1 
ATOM   23   S SD  . MET A 1 17  ? -18.98063 25.58395  23.93923 1.000 65.83735 ? 11  MET A SD  1 
ATOM   24   C CE  . MET A 1 17  ? -18.28015 27.19612  24.31249 1.000 65.61282 ? 11  MET A CE  1 
ATOM   25   N N   . VAL A 1 18  ? -19.92141 24.72113  29.31413 1.000 59.76877 ? 12  VAL A N   1 
ATOM   26   C CA  . VAL A 1 18  ? -20.02858 24.89358  30.75956 1.000 59.72548 ? 12  VAL A CA  1 
ATOM   27   C C   . VAL A 1 18  ? -18.99086 25.91837  31.19509 1.000 61.01585 ? 12  VAL A C   1 
ATOM   28   O O   . VAL A 1 18  ? -17.79439 25.75203  30.91713 1.000 60.54475 ? 12  VAL A O   1 
ATOM   29   C CB  . VAL A 1 18  ? -19.82274 23.57919  31.53363 1.000 58.95954 ? 12  VAL A CB  1 
ATOM   30   C CG1 . VAL A 1 18  ? -20.05984 23.81253  33.00504 1.000 58.39270 ? 12  VAL A CG1 1 
ATOM   31   C CG2 . VAL A 1 18  ? -20.74371 22.49788  31.01865 1.000 58.55565 ? 12  VAL A CG2 1 
ATOM   32   N N   . ARG A 1 19  ? -19.45113 26.97380  31.87761 1.000 62.23859 ? 13  ARG A N   1 
ATOM   33   C CA  . ARG A 1 19  ? -18.60825 28.06977  32.36832 1.000 62.85362 ? 13  ARG A CA  1 
ATOM   34   C C   . ARG A 1 19  ? -17.61889 28.54318  31.30312 1.000 63.08579 ? 13  ARG A C   1 
ATOM   35   O O   . ARG A 1 19  ? -16.40949 28.64929  31.53178 1.000 62.45368 ? 13  ARG A O   1 
ATOM   36   C CB  . ARG A 1 19  ? -17.89531 27.66859  33.65640 1.000 63.28471 ? 13  ARG A CB  1 
ATOM   37   C CG  . ARG A 1 19  ? -18.85459 27.18301  34.72628 0.829 63.98275 ? 13  ARG A CG  1 
ATOM   38   C CD  . ARG A 1 19  ? -18.46404 27.65361  36.11652 0.422 64.54924 ? 13  ARG A CD  1 
ATOM   39   N NE  . ARG A 1 19  ? -19.43791 27.23939  37.12098 0.714 65.21029 ? 13  ARG A NE  1 
ATOM   40   C CZ  . ARG A 1 19  ? -19.36965 27.55993  38.40538 0.730 65.83981 ? 13  ARG A CZ  1 
ATOM   41   N NH1 . ARG A 1 19  ? -18.36916 28.28149  38.88378 0.514 65.87752 ? 13  ARG A NH1 1 
ATOM   42   N NH2 . ARG A 1 19  ? -20.32124 27.13416  39.23407 0.756 66.16117 ? 13  ARG A NH2 1 
ATOM   43   N N   . GLY A 1 20  ? -18.15682 28.83478  30.11774 1.000 63.64924 ? 14  GLY A N   1 
ATOM   44   C CA  . GLY A 1 20  ? -17.37823 29.37270  29.02554 1.000 63.49897 ? 14  GLY A CA  1 
ATOM   45   C C   . GLY A 1 20  ? -16.51857 28.37287  28.28884 1.000 63.35110 ? 14  GLY A C   1 
ATOM   46   O O   . GLY A 1 20  ? -15.91018 28.73959  27.26664 1.000 64.10741 ? 14  GLY A O   1 
ATOM   47   N N   . GLN A 1 21  ? -16.45282 27.12433  28.75552 1.000 61.16615 ? 15  GLN A N   1 
ATOM   48   C CA  . GLN A 1 21  ? -15.57724 26.11466  28.17855 1.000 59.22298 ? 15  GLN A CA  1 
ATOM   49   C C   . GLN A 1 21  ? -16.37741 25.00035  27.51529 1.000 56.46759 ? 15  GLN A C   1 
ATOM   50   O O   . GLN A 1 21  ? -17.45030 24.62183  27.99340 1.000 57.30613 ? 15  GLN A O   1 
ATOM   51   C CB  . GLN A 1 21  ? -14.65768 25.52475  29.24447 1.000 59.00011 ? 15  GLN A CB  1 
ATOM   52   C CG  . GLN A 1 21  ? -13.65104 26.52459  29.77271 0.805 59.49479 ? 15  GLN A CG  1 
ATOM   53   C CD  . GLN A 1 21  ? -12.63404 25.88984  30.68768 0.570 59.60860 ? 15  GLN A CD  1 
ATOM   54   O OE1 . GLN A 1 21  ? -12.85476 24.79904  31.22579 0.799 59.60932 ? 15  GLN A OE1 1 
ATOM   55   N NE2 . GLN A 1 21  ? -11.49211 26.55303  30.84715 0.652 59.80049 ? 15  GLN A NE2 1 
ATOM   56   N N   . VAL A 1 22  ? -15.83813 24.48865  26.40422 1.000 53.29183 ? 16  VAL A N   1 
ATOM   57   C CA  . VAL A 1 22  ? -16.41421 23.32441  25.74234 1.000 49.23563 ? 16  VAL A CA  1 
ATOM   58   C C   . VAL A 1 22  ? -16.38596 22.13355  26.69113 1.000 46.34323 ? 16  VAL A C   1 
ATOM   59   O O   . VAL A 1 22  ? -15.40057 21.89004  27.40129 1.000 45.80518 ? 16  VAL A O   1 
ATOM   60   C CB  . VAL A 1 22  ? -15.65142 23.01257  24.44446 1.000 48.85478 ? 16  VAL A CB  1 
ATOM   61   C CG1 . VAL A 1 22  ? -16.26265 21.82521  23.74350 1.000 48.89009 ? 16  VAL A CG1 1 
ATOM   62   C CG2 . VAL A 1 22  ? -15.64785 24.24243  23.50505 1.000 48.88422 ? 16  VAL A CG2 1 
ATOM   63   N N   . PHE A 1 23  ? -17.48634 21.40022  26.72092 1.000 43.03027 ? 17  PHE A N   1 
ATOM   64   C CA  . PHE A 1 23  ? -17.60015 20.18202  27.50618 1.000 41.15129 ? 17  PHE A CA  1 
ATOM   65   C C   . PHE A 1 23  ? -18.30295 19.17148  26.58841 1.000 40.11447 ? 17  PHE A C   1 
ATOM   66   O O   . PHE A 1 23  ? -19.51001 18.95609  26.64085 1.000 41.85524 ? 17  PHE A O   1 
ATOM   67   C CB  . PHE A 1 23  ? -18.33275 20.42777  28.82286 1.000 40.29733 ? 17  PHE A CB  1 
ATOM   68   C CG  . PHE A 1 23  ? -17.86466 19.53154  29.92001 1.000 37.76600 ? 17  PHE A CG  1 
ATOM   69   C CD1 . PHE A 1 23  ? -18.45085 18.29581  30.07581 1.000 37.46561 ? 17  PHE A CD1 1 
ATOM   70   C CD2 . PHE A 1 23  ? -16.83717 19.90265  30.78600 1.000 37.39652 ? 17  PHE A CD2 1 
ATOM   71   C CE1 . PHE A 1 23  ? -18.02716 17.43045  31.03867 1.000 35.58462 ? 17  PHE A CE1 1 
ATOM   72   C CE2 . PHE A 1 23  ? -16.39737 19.01214  31.77302 1.000 36.70122 ? 17  PHE A CE2 1 
ATOM   73   C CZ  . PHE A 1 23  ? -16.99668 17.78911  31.89538 1.000 35.78164 ? 17  PHE A CZ  1 
ATOM   74   N N   . ASP A 1 24  ? -17.51914 18.56267  25.70321 1.000 38.15641 ? 18  ASP A N   1 
ATOM   75   C CA  . ASP A 1 24  ? -18.02342 17.96797  24.47010 1.000 35.82580 ? 18  ASP A CA  1 
ATOM   76   C C   . ASP A 1 24  ? -18.24053 16.46892  24.63287 1.000 35.64564 ? 18  ASP A C   1 
ATOM   77   O O   . ASP A 1 24  ? -17.42098 15.64074  24.24322 1.000 36.42773 ? 18  ASP A O   1 
ATOM   78   C CB  . ASP A 1 24  ? -17.05291 18.26273  23.34306 0.873 36.10390 ? 18  ASP A CB  1 
ATOM   79   C CG  . ASP A 1 24  ? -17.66961 18.02271  21.99822 1.000 36.62742 ? 18  ASP A CG  1 
ATOM   80   O OD1 . ASP A 1 24  ? -18.89455 17.80547  21.96935 0.565 37.48363 ? 18  ASP A OD1 1 
ATOM   81   O OD2 . ASP A 1 24  ? -16.94503 18.09058  21.00101 0.668 37.33980 ? 18  ASP A OD2 1 
ATOM   82   N N   . VAL A 1 25  ? -19.38323 16.11174  25.21434 1.000 34.69973 ? 19  VAL A N   1 
ATOM   83   C CA  . VAL A 1 25  ? -19.62004 14.73763  25.62479 1.000 33.94571 ? 19  VAL A CA  1 
ATOM   84   C C   . VAL A 1 25  ? -20.89627 14.16788  25.04844 1.000 35.88618 ? 19  VAL A C   1 
ATOM   85   O O   . VAL A 1 25  ? -21.22233 13.01455  25.32585 1.000 36.25071 ? 19  VAL A O   1 
ATOM   86   C CB  . VAL A 1 25  ? -19.64571 14.63720  27.15590 1.000 31.36863 ? 19  VAL A CB  1 
ATOM   87   C CG1 . VAL A 1 25  ? -18.32491 15.10602  27.71402 1.000 32.75948 ? 19  VAL A CG1 1 
ATOM   88   C CG2 . VAL A 1 25  ? -20.80596 15.45880  27.70108 1.000 31.82356 ? 19  VAL A CG2 1 
ATOM   89   N N   . GLY A 1 26  ? -21.64625 14.93934  24.28842 1.000 38.92486 ? 20  GLY A N   1 
ATOM   90   C CA  . GLY A 1 26  ? -22.89282 14.45262  23.74634 1.000 38.57445 ? 20  GLY A CA  1 
ATOM   91   C C   . GLY A 1 26  ? -22.65072 13.59259  22.53141 1.000 39.12832 ? 20  GLY A C   1 
ATOM   92   O O   . GLY A 1 26  ? -21.51438 13.47417  22.00529 1.000 40.05090 ? 20  GLY A O   1 
ATOM   93   N N   . PRO A 1 27  ? -23.72659 12.98327  22.03772 1.000 37.53438 ? 21  PRO A N   1 
ATOM   94   C CA  . PRO A 1 27  ? -25.08636 13.15062  22.57022 1.000 35.17139 ? 21  PRO A CA  1 
ATOM   95   C C   . PRO A 1 27  ? -25.43757 12.18623  23.70914 1.000 33.88815 ? 21  PRO A C   1 
ATOM   96   O O   . PRO A 1 27  ? -26.53188 12.30812  24.28679 1.000 35.21967 ? 21  PRO A O   1 
ATOM   97   C CB  . PRO A 1 27  ? -25.96141 12.85431  21.36175 1.000 36.37015 ? 21  PRO A CB  1 
ATOM   98   C CG  . PRO A 1 27  ? -25.16125 11.81754  20.61826 1.000 37.31248 ? 21  PRO A CG  1 
ATOM   99   C CD  . PRO A 1 27  ? -23.72562 12.27332  20.74433 1.000 37.54161 ? 21  PRO A CD  1 
ATOM   100  N N   . ARG A 1 28  ? -24.56408 11.22609  24.01666 1.000 32.25803 ? 22  ARG A N   1 
ATOM   101  C CA  . ARG A 1 28  ? -24.92448 10.25434  25.04634 1.000 31.85751 ? 22  ARG A CA  1 
ATOM   102  C C   . ARG A 1 28  ? -25.12467 10.93843  26.39486 1.000 32.75562 ? 22  ARG A C   1 
ATOM   103  O O   . ARG A 1 28  ? -26.03299 10.58093  27.15140 1.000 34.65422 ? 22  ARG A O   1 
ATOM   104  C CB  . ARG A 1 28  ? -23.87514 9.15083   25.14191 1.000 32.69672 ? 22  ARG A CB  1 
ATOM   105  C CG  . ARG A 1 28  ? -24.13712 8.23581   26.34638 1.000 33.19257 ? 22  ARG A CG  1 
ATOM   106  C CD  . ARG A 1 28  ? -23.29777 7.00143   26.31024 1.000 33.80619 ? 22  ARG A CD  1 
ATOM   107  N NE  . ARG A 1 28  ? -23.52593 6.20475   27.50520 1.000 33.91670 ? 22  ARG A NE  1 
ATOM   108  C CZ  . ARG A 1 28  ? -22.80125 5.14675   27.83413 1.000 34.02791 ? 22  ARG A CZ  1 
ATOM   109  N NH1 . ARG A 1 28  ? -21.80313 4.72786   27.06994 1.000 33.70790 ? 22  ARG A NH1 1 
ATOM   110  N NH2 . ARG A 1 28  ? -23.04882 4.52742   28.98272 1.000 35.15474 ? 22  ARG A NH2 1 
ATOM   111  N N   . TYR A 1 29  ? -24.32145 11.95137  26.69872 1.000 32.12131 ? 23  TYR A N   1 
ATOM   112  C CA  . TYR A 1 29  ? -24.35016 12.58578  28.00710 1.000 31.19872 ? 23  TYR A CA  1 
ATOM   113  C C   . TYR A 1 29  ? -24.82442 14.01779  27.82364 1.000 34.25449 ? 23  TYR A C   1 
ATOM   114  O O   . TYR A 1 29  ? -24.24638 14.76758  27.01600 1.000 35.28463 ? 23  TYR A O   1 
ATOM   115  C CB  . TYR A 1 29  ? -22.97739 12.53948  28.65093 1.000 29.76618 ? 23  TYR A CB  1 
ATOM   116  C CG  . TYR A 1 29  ? -22.41132 11.13215  28.75854 1.000 27.92717 ? 23  TYR A CG  1 
ATOM   117  C CD1 . TYR A 1 29  ? -22.77544 10.28373  29.80466 1.000 28.09059 ? 23  TYR A CD1 1 
ATOM   118  C CD2 . TYR A 1 29  ? -21.51845 10.65939  27.80785 1.000 25.52205 ? 23  TYR A CD2 1 
ATOM   119  C CE1 . TYR A 1 29  ? -22.25226 9.01729   29.92083 1.000 27.58420 ? 23  TYR A CE1 1 
ATOM   120  C CE2 . TYR A 1 29  ? -20.97065 9.39096   27.90173 1.000 25.92571 ? 23  TYR A CE2 1 
ATOM   121  C CZ  . TYR A 1 29  ? -21.34734 8.57301   28.97183 1.000 26.88291 ? 23  TYR A CZ  1 
ATOM   122  O OH  . TYR A 1 29  ? -20.82640 7.32553   29.10315 1.000 27.04384 ? 23  TYR A OH  1 
ATOM   123  N N   . THR A 1 30  ? -25.89244 14.37505  28.53915 1.000 34.55161 ? 24  THR A N   1 
ATOM   124  C CA  . THR A 1 30  ? -26.58449 15.64756  28.37221 1.000 36.30054 ? 24  THR A CA  1 
ATOM   125  C C   . THR A 1 30  ? -26.92899 16.21285  29.74913 1.000 37.90770 ? 24  THR A C   1 
ATOM   126  O O   . THR A 1 30  ? -26.76896 15.54821  30.77311 1.000 36.66489 ? 24  THR A O   1 
ATOM   127  C CB  . THR A 1 30  ? -27.87583 15.48239  27.54482 1.000 38.42413 ? 24  THR A CB  1 
ATOM   128  O OG1 . THR A 1 30  ? -28.72476 14.48842  28.15749 1.000 38.64324 ? 24  THR A OG1 1 
ATOM   129  C CG2 . THR A 1 30  ? -27.55029 15.08370  26.10154 1.000 37.83142 ? 24  THR A CG2 1 
ATOM   130  N N   . ASN A 1 31  ? -27.42369 17.45463  29.76103 1.000 39.44609 ? 25  ASN A N   1 
ATOM   131  C CA  . ASN A 1 31  ? -27.93067 18.11828  30.97034 1.000 40.14925 ? 25  ASN A CA  1 
ATOM   132  C C   . ASN A 1 31  ? -26.82169 18.24841  32.01956 1.000 39.25973 ? 25  ASN A C   1 
ATOM   133  O O   . ASN A 1 31  ? -26.90413 17.70127  33.10275 1.000 38.93977 ? 25  ASN A O   1 
ATOM   134  C CB  . ASN A 1 31  ? -29.14870 17.36249  31.54105 1.000 41.37221 ? 25  ASN A CB  1 
ATOM   135  C CG  . ASN A 1 31  ? -30.08822 18.25764  32.36154 0.605 43.39745 ? 25  ASN A CG  1 
ATOM   136  O OD1 . ASN A 1 31  ? -29.78574 19.41736  32.66848 0.892 45.41967 ? 25  ASN A OD1 1 
ATOM   137  N ND2 . ASN A 1 31  ? -31.23560 17.70360  32.72912 0.393 43.54412 ? 25  ASN A ND2 1 
ATOM   138  N N   . LEU A 1 32  ? -25.80131 19.03651  31.67066 1.000 38.72825 ? 26  LEU A N   1 
ATOM   139  C CA  . LEU A 1 32  ? -24.55183 19.10881  32.41873 1.000 39.26394 ? 26  LEU A CA  1 
ATOM   140  C C   . LEU A 1 32  ? -24.63777 20.11218  33.57477 1.000 39.04812 ? 26  LEU A C   1 
ATOM   141  O O   . LEU A 1 32  ? -25.24528 21.18226  33.43685 1.000 40.85804 ? 26  LEU A O   1 
ATOM   142  C CB  . LEU A 1 32  ? -23.43293 19.53587  31.47033 1.000 40.93834 ? 26  LEU A CB  1 
ATOM   143  C CG  . LEU A 1 32  ? -22.59810 18.49833  30.72069 1.000 42.78699 ? 26  LEU A CG  1 
ATOM   144  C CD1 . LEU A 1 32  ? -23.46215 17.33624  30.27000 1.000 43.17628 ? 26  LEU A CD1 1 
ATOM   145  C CD2 . LEU A 1 32  ? -21.94590 19.16483  29.51643 1.000 43.25631 ? 26  LEU A CD2 1 
ATOM   146  N N   . SER A 1 33  ? -24.02522 19.77432  34.71235 1.000 38.69093 ? 27  SER A N   1 
ATOM   147  C CA  . SER A 1 33  ? -23.90491 20.70049  35.83080 1.000 39.68551 ? 27  SER A CA  1 
ATOM   148  C C   . SER A 1 33  ? -22.49542 20.63989  36.40341 1.000 40.51073 ? 27  SER A C   1 
ATOM   149  O O   . SER A 1 33  ? -21.94836 19.55645  36.59501 1.000 39.13066 ? 27  SER A O   1 
ATOM   150  C CB  . SER A 1 33  ? -24.88965 20.36939  36.95405 1.000 41.18639 ? 27  SER A CB  1 
ATOM   151  O OG  . SER A 1 33  ? -26.15973 20.06681  36.42849 1.000 44.23270 ? 27  SER A OG  1 
ATOM   152  N N   . TYR A 1 34  ? -21.93783 21.79095  36.74650 1.000 42.61029 ? 28  TYR A N   1 
ATOM   153  C CA  . TYR A 1 34  ? -20.64132 21.79334  37.40110 1.000 45.23762 ? 28  TYR A CA  1 
ATOM   154  C C   . TYR A 1 34  ? -20.76354 21.15775  38.79132 1.000 45.44302 ? 28  TYR A C   1 
ATOM   155  O O   . TYR A 1 34  ? -21.73957 21.39970  39.51483 1.000 45.62828 ? 28  TYR A O   1 
ATOM   156  C CB  . TYR A 1 34  ? -20.08445 23.23119  37.46047 1.000 47.18232 ? 28  TYR A CB  1 
ATOM   157  C CG  . TYR A 1 34  ? -18.75958 23.35052  38.20002 0.991 49.53840 ? 28  TYR A CG  1 
ATOM   158  C CD1 . TYR A 1 34  ? -17.60684 23.71221  37.51503 0.815 50.49518 ? 28  TYR A CD1 1 
ATOM   159  C CD2 . TYR A 1 34  ? -18.67478 23.18471  39.58093 0.849 50.57602 ? 28  TYR A CD2 1 
ATOM   160  C CE1 . TYR A 1 34  ? -16.39372 23.82617  38.16805 0.903 50.98638 ? 28  TYR A CE1 1 
ATOM   161  C CE2 . TYR A 1 34  ? -17.46375 23.29000  40.24755 0.833 51.22442 ? 28  TYR A CE2 1 
ATOM   162  C CZ  . TYR A 1 34  ? -16.33515 23.62442  39.53871 0.652 51.39364 ? 28  TYR A CZ  1 
ATOM   163  O OH  . TYR A 1 34  ? -15.14029 23.74579  40.19529 0.736 52.19139 ? 28  TYR A OH  1 
ATOM   164  N N   . ILE A 1 35  ? -19.77056 20.32170  39.14995 1.000 45.19539 ? 29  ILE A N   1 
ATOM   165  C CA  . ILE A 1 35  ? -19.71819 19.61421  40.43540 1.000 44.72544 ? 29  ILE A CA  1 
ATOM   166  C C   . ILE A 1 35  ? -18.34562 19.57270  41.12437 1.000 46.01473 ? 29  ILE A C   1 
ATOM   167  O O   . ILE A 1 35  ? -18.26301 19.24239  42.31763 1.000 47.28928 ? 29  ILE A O   1 
ATOM   168  C CB  . ILE A 1 35  ? -20.28155 18.17965  40.29950 1.000 43.16021 ? 29  ILE A CB  1 
ATOM   169  C CG1 . ILE A 1 35  ? -19.24496 17.19592  39.77783 1.000 40.62861 ? 29  ILE A CG1 1 
ATOM   170  C CG2 . ILE A 1 35  ? -21.55032 18.10695  39.50834 1.000 44.18232 ? 29  ILE A CG2 1 
ATOM   171  C CD1 . ILE A 1 35  ? -19.76934 15.80041  39.77830 1.000 39.54516 ? 29  ILE A CD1 1 
ATOM   172  N N   . GLY A 1 36  ? -17.26573 19.90677  40.42918 1.000 44.81844 ? 30  GLY A N   1 
ATOM   173  C CA  . GLY A 1 36  ? -15.96376 19.83111  41.08725 1.000 43.71724 ? 30  GLY A CA  1 
ATOM   174  C C   . GLY A 1 36  ? -14.81260 20.08446  40.13299 1.000 42.87316 ? 30  GLY A C   1 
ATOM   175  O O   . GLY A 1 36  ? -15.00845 20.49650  38.98311 1.000 44.27161 ? 30  GLY A O   1 
ATOM   176  N N   . GLU A 1 37  ? -13.59189 19.82438  40.62368 1.000 41.23962 ? 31  GLU A N   1 
ATOM   177  C CA  . GLU A 1 37  ? -12.37789 20.10871  39.87193 1.000 40.43629 ? 31  GLU A CA  1 
ATOM   178  C C   . GLU A 1 37  ? -11.42259 18.92313  39.89951 1.000 38.52219 ? 31  GLU A C   1 
ATOM   179  O O   . GLU A 1 37  ? -11.06923 18.44490  40.97472 1.000 37.56636 ? 31  GLU A O   1 
ATOM   180  C CB  . GLU A 1 37  ? -11.65750 21.33345  40.43440 1.000 42.54984 ? 31  GLU A CB  1 
ATOM   181  C CG  . GLU A 1 37  ? -12.37115 22.64597  40.19631 1.000 45.76805 ? 31  GLU A CG  1 
ATOM   182  C CD  . GLU A 1 37  ? -12.33116 23.09140  38.75801 1.000 48.01191 ? 31  GLU A CD  1 
ATOM   183  O OE1 . GLU A 1 37  ? -11.41494 22.67063  38.01753 1.000 48.46807 ? 31  GLU A OE1 1 
ATOM   184  O OE2 . GLU A 1 37  ? -13.20509 23.89203  38.37182 1.000 49.28550 ? 31  GLU A OE2 1 
ATOM   185  N N   . GLY A 1 38  ? -10.98759 18.47144  38.71896 1.000 37.86107 ? 32  GLY A N   1 
ATOM   186  C CA  . GLY A 1 38  ? -9.88898  17.53656  38.59974 1.000 38.64849 ? 32  GLY A CA  1 
ATOM   187  C C   . GLY A 1 38  ? -8.58438  18.25949  38.32610 1.000 39.53678 ? 32  GLY A C   1 
ATOM   188  O O   . GLY A 1 38  ? -8.50445  19.48448  38.37633 1.000 40.72122 ? 32  GLY A O   1 
ATOM   189  N N   . ALA A 1 39  ? -7.53837  17.48248  38.03985 1.000 40.45431 ? 33  ALA A N   1 
ATOM   190  C CA  . ALA A 1 39  ? -6.21188  18.09732  37.93043 1.000 42.72955 ? 33  ALA A CA  1 
ATOM   191  C C   . ALA A 1 39  ? -6.09820  18.96155  36.68481 1.000 44.79055 ? 33  ALA A C   1 
ATOM   192  O O   . ALA A 1 39  ? -5.43209  19.99961  36.70390 1.000 44.73995 ? 33  ALA A O   1 
ATOM   193  C CB  . ALA A 1 39  ? -5.12066  17.02895  37.91477 1.000 43.19660 ? 33  ALA A CB  1 
ATOM   194  N N   . TYR A 1 40  ? -6.72771  18.54890  35.58726 1.000 45.79900 ? 34  TYR A N   1 
ATOM   195  C CA  . TYR A 1 40  ? -6.50540  19.21997  34.30792 1.000 45.64464 ? 34  TYR A CA  1 
ATOM   196  C C   . TYR A 1 40  ? -7.82531  19.64559  33.68542 1.000 43.98551 ? 34  TYR A C   1 
ATOM   197  O O   . TYR A 1 40  ? -7.94568  19.71247  32.44895 1.000 44.49777 ? 34  TYR A O   1 
ATOM   198  C CB  . TYR A 1 40  ? -5.71848  18.30994  33.36411 1.000 47.25917 ? 34  TYR A CB  1 
ATOM   199  C CG  . TYR A 1 40  ? -4.41299  17.90389  34.00634 1.000 48.58857 ? 34  TYR A CG  1 
ATOM   200  C CD1 . TYR A 1 40  ? -3.51566  18.86820  34.45644 1.000 49.68886 ? 34  TYR A CD1 1 
ATOM   201  C CD2 . TYR A 1 40  ? -4.08970  16.56222  34.19830 1.000 49.64454 ? 34  TYR A CD2 1 
ATOM   202  C CE1 . TYR A 1 40  ? -2.32701  18.50493  35.08367 1.000 50.26546 ? 34  TYR A CE1 1 
ATOM   203  C CE2 . TYR A 1 40  ? -2.89897  16.18550  34.82236 1.000 49.84847 ? 34  TYR A CE2 1 
ATOM   204  C CZ  . TYR A 1 40  ? -2.02344  17.16870  35.25594 1.000 50.32435 ? 34  TYR A CZ  1 
ATOM   205  O OH  . TYR A 1 40  ? -0.83227  16.84621  35.86076 1.000 51.25026 ? 34  TYR A OH  1 
ATOM   206  N N   . GLY A 1 41  ? -8.82816  19.90616  34.51623 1.000 41.79201 ? 35  GLY A N   1 
ATOM   207  C CA  . GLY A 1 41  ? -10.13063 20.27360  33.99357 1.000 40.93905 ? 35  GLY A CA  1 
ATOM   208  C C   . GLY A 1 41  ? -11.21712 20.11938  35.03121 1.000 39.11747 ? 35  GLY A C   1 
ATOM   209  O O   . GLY A 1 41  ? -10.98640 19.65036  36.14755 1.000 39.82525 ? 35  GLY A O   1 
ATOM   210  N N   . MET A 1 42  ? -12.41750 20.53415  34.63206 1.000 36.84885 ? 36  MET A N   1 
ATOM   211  C CA  . MET A 1 42  ? -13.54102 20.52365  35.54671 1.000 36.65160 ? 36  MET A CA  1 
ATOM   212  C C   . MET A 1 42  ? -14.20432 19.15574  35.54588 1.000 34.03053 ? 36  MET A C   1 
ATOM   213  O O   . MET A 1 42  ? -14.06216 18.35073  34.60780 1.000 32.91276 ? 36  MET A O   1 
ATOM   214  C CB  . MET A 1 42  ? -14.59465 21.58142  35.18282 1.000 38.03933 ? 36  MET A CB  1 
ATOM   215  C CG  . MET A 1 42  ? -15.01128 21.60594  33.73155 0.832 39.44763 ? 36  MET A CG  1 
ATOM   216  S SD  . MET A 1 42  ? -16.45364 22.69969  33.45975 0.523 40.68533 ? 36  MET A SD  1 
ATOM   217  C CE  . MET A 1 42  ? -15.70031 24.27796  33.75732 0.897 40.95652 ? 36  MET A CE  1 
ATOM   218  N N   . VAL A 1 43  ? -14.96427 18.91580  36.60520 1.000 32.18228 ? 37  VAL A N   1 
ATOM   219  C CA  . VAL A 1 43  ? -15.83406 17.75748  36.70098 1.000 31.10665 ? 37  VAL A CA  1 
ATOM   220  C C   . VAL A 1 43  ? -17.26184 18.26810  36.61107 1.000 32.07305 ? 37  VAL A C   1 
ATOM   221  O O   . VAL A 1 43  ? -17.59695 19.28676  37.22356 1.000 33.98086 ? 37  VAL A O   1 
ATOM   222  C CB  . VAL A 1 43  ? -15.60671 16.98733  38.00659 1.000 28.64979 ? 37  VAL A CB  1 
ATOM   223  C CG1 . VAL A 1 43  ? -16.43563 15.73450  38.00622 1.000 29.01712 ? 37  VAL A CG1 1 
ATOM   224  C CG2 . VAL A 1 43  ? -14.10637 16.69031  38.19306 1.000 28.58510 ? 37  VAL A CG2 1 
ATOM   225  N N   . CYS A 1 44  ? -18.09250 17.57802  35.83403 1.000 31.12304 ? 38  CYS A N   1 
ATOM   226  C CA  . CYS A 1 44  ? -19.50767 17.87841  35.73557 1.000 32.13728 ? 38  CYS A CA  1 
ATOM   227  C C   . CYS A 1 44  ? -20.29654 16.62397  36.04877 1.000 31.30322 ? 38  CYS A C   1 
ATOM   228  O O   . CYS A 1 44  ? -19.79423 15.51082  35.94295 1.000 30.38789 ? 38  CYS A O   1 
ATOM   229  C CB  . CYS A 1 44  ? -19.89323 18.36215  34.35038 1.000 34.04300 ? 38  CYS A CB  1 
ATOM   230  S SG  . CYS A 1 44  ? -19.38328 20.06436  34.01373 1.000 38.18042 ? 38  CYS A SG  1 
ATOM   231  N N   . SER A 1 45  ? -21.52880 16.81100  36.47696 1.000 31.19829 ? 39  SER A N   1 
ATOM   232  C CA  . SER A 1 45  ? -22.45937 15.70957  36.39232 1.000 30.61877 ? 39  SER A CA  1 
ATOM   233  C C   . SER A 1 45  ? -23.20949 15.81587  35.07552 1.000 30.95742 ? 39  SER A C   1 
ATOM   234  O O   . SER A 1 45  ? -23.24986 16.87843  34.43904 1.000 32.56120 ? 39  SER A O   1 
ATOM   235  C CB  . SER A 1 45  ? -23.41879 15.71437  37.57255 1.000 30.52553 ? 39  SER A CB  1 
ATOM   236  O OG  . SER A 1 45  ? -24.26798 16.85964  37.50776 1.000 31.91339 ? 39  SER A OG  1 
ATOM   237  N N   . ALA A 1 46  ? -23.78599 14.68849  34.65569 1.000 29.93127 ? 40  ALA A N   1 
ATOM   238  C CA  . ALA A 1 46  ? -24.45224 14.62271  33.36652 1.000 29.40585 ? 40  ALA A CA  1 
ATOM   239  C C   . ALA A 1 46  ? -25.44380 13.47784  33.39522 1.000 29.87301 ? 40  ALA A C   1 
ATOM   240  O O   . ALA A 1 46  ? -25.28800 12.51932  34.16043 1.000 29.77707 ? 40  ALA A O   1 
ATOM   241  C CB  . ALA A 1 46  ? -23.44463 14.40025  32.22158 1.000 28.45851 ? 40  ALA A CB  1 
ATOM   242  N N   . TYR A 1 47  ? -26.42313 13.54100  32.50228 1.000 30.39452 ? 41  TYR A N   1 
ATOM   243  C CA  . TYR A 1 47  ? -27.32358 12.41654  32.34728 1.000 31.99654 ? 41  TYR A CA  1 
ATOM   244  C C   . TYR A 1 47  ? -26.82622 11.49874  31.23547 1.000 33.28984 ? 41  TYR A C   1 
ATOM   245  O O   . TYR A 1 47  ? -26.58052 11.93911  30.10456 1.000 33.94978 ? 41  TYR A O   1 
ATOM   246  C CB  . TYR A 1 47  ? -28.74203 12.90291  32.08054 1.000 33.46031 ? 41  TYR A CB  1 
ATOM   247  C CG  . TYR A 1 47  ? -29.75893 11.78512  31.97302 0.772 33.84202 ? 41  TYR A CG  1 
ATOM   248  C CD1 . TYR A 1 47  ? -30.25551 11.17770  33.11793 0.916 34.94105 ? 41  TYR A CD1 1 
ATOM   249  C CD2 . TYR A 1 47  ? -30.32481 11.43543  30.74568 0.611 35.49338 ? 41  TYR A CD2 1 
ATOM   250  C CE1 . TYR A 1 47  ? -31.22816 10.18443  33.04006 0.986 35.18573 ? 41  TYR A CE1 1 
ATOM   251  C CE2 . TYR A 1 47  ? -31.29592 10.45773  30.65827 0.886 35.75605 ? 41  TYR A CE2 1 
ATOM   252  C CZ  . TYR A 1 47  ? -31.74578 9.83001   31.80508 0.677 35.99352 ? 41  TYR A CZ  1 
ATOM   253  O OH  . TYR A 1 47  ? -32.72307 8.85141   31.71442 0.625 36.66902 ? 41  TYR A OH  1 
ATOM   254  N N   . ASP A 1 48  ? -26.67213 10.22313  31.58081 1.000 33.68593 ? 42  ASP A N   1 
ATOM   255  C CA  . ASP A 1 48  ? -26.30132 9.14630   30.66637 1.000 34.08325 ? 42  ASP A CA  1 
ATOM   256  C C   . ASP A 1 48  ? -27.58246 8.62049   30.01431 1.000 36.44168 ? 42  ASP A C   1 
ATOM   257  O O   . ASP A 1 48  ? -28.37089 7.90044   30.64586 1.000 35.98738 ? 42  ASP A O   1 
ATOM   258  C CB  . ASP A 1 48  ? -25.57409 8.06686   31.45664 1.000 34.33125 ? 42  ASP A CB  1 
ATOM   259  C CG  . ASP A 1 48  ? -25.08695 6.92611   30.60874 1.000 33.95413 ? 42  ASP A CG  1 
ATOM   260  O OD1 . ASP A 1 48  ? -25.56762 6.74187   29.48117 1.000 34.54411 ? 42  ASP A OD1 1 
ATOM   261  O OD2 . ASP A 1 48  ? -24.21421 6.18734   31.09225 1.000 35.48822 ? 42  ASP A OD2 1 
ATOM   262  N N   . ASN A 1 49  ? -27.79529 8.96973   28.74613 1.000 36.75527 ? 43  ASN A N   1 
ATOM   263  C CA  . ASN A 1 49  ? -29.03337 8.58852   28.08498 1.000 39.08975 ? 43  ASN A CA  1 
ATOM   264  C C   . ASN A 1 49  ? -29.09871 7.10013   27.80686 1.000 40.74805 ? 43  ASN A C   1 
ATOM   265  O O   . ASN A 1 49  ? -30.20173 6.57555   27.59383 1.000 42.03896 ? 43  ASN A O   1 
ATOM   266  C CB  . ASN A 1 49  ? -29.20556 9.40290   26.79613 1.000 39.33446 ? 43  ASN A CB  1 
ATOM   267  C CG  . ASN A 1 49  ? -29.57482 10.84630  27.09444 1.000 39.61116 ? 43  ASN A CG  1 
ATOM   268  O OD1 . ASN A 1 49  ? -30.76152 11.17527  27.24426 1.000 40.59484 ? 43  ASN A OD1 1 
ATOM   269  N ND2 . ASN A 1 49  ? -28.56208 11.70577  27.25811 1.000 39.91036 ? 43  ASN A ND2 1 
ATOM   270  N N   . LEU A 1 50  ? -27.95935 6.40163   27.81345 1.000 41.81894 ? 44  LEU A N   1 
ATOM   271  C CA  . LEU A 1 50  ? -27.98600 4.94519   27.65802 1.000 43.06458 ? 44  LEU A CA  1 
ATOM   272  C C   . LEU A 1 50  ? -28.35711 4.23866   28.96050 1.000 43.41800 ? 44  LEU A C   1 
ATOM   273  O O   . LEU A 1 50  ? -29.29769 3.43625   29.00703 1.000 44.62245 ? 44  LEU A O   1 
ATOM   274  C CB  . LEU A 1 50  ? -26.62787 4.44752   27.16239 1.000 43.94399 ? 44  LEU A CB  1 
ATOM   275  C CG  . LEU A 1 50  ? -26.50010 3.04092   26.57513 1.000 45.54554 ? 44  LEU A CG  1 
ATOM   276  C CD1 . LEU A 1 50  ? -25.09108 2.84079   26.05227 1.000 44.20444 ? 44  LEU A CD1 1 
ATOM   277  C CD2 . LEU A 1 50  ? -26.76397 1.97139   27.60015 1.000 48.18405 ? 44  LEU A CD2 1 
ATOM   278  N N   . ASN A 1 51  ? -27.58575 4.45919   30.00698 1.000 44.07493 ? 45  ASN A N   1 
ATOM   279  C CA  . ASN A 1 51  ? -27.82303 3.74085   31.25550 1.000 44.04012 ? 45  ASN A CA  1 
ATOM   280  C C   . ASN A 1 51  ? -28.90640 4.39681   32.09722 1.000 42.71917 ? 45  ASN A C   1 
ATOM   281  O O   . ASN A 1 51  ? -29.29681 3.84390   33.12812 1.000 43.04782 ? 45  ASN A O   1 
ATOM   282  C CB  . ASN A 1 51  ? -26.50598 3.62176   32.04792 1.000 44.52853 ? 45  ASN A CB  1 
ATOM   283  C CG  . ASN A 1 51  ? -25.48177 2.70006   31.37031 1.000 45.77341 ? 45  ASN A CG  1 
ATOM   284  O OD1 . ASN A 1 51  ? -25.84662 1.79174   30.62355 1.000 48.01028 ? 45  ASN A OD1 1 
ATOM   285  N ND2 . ASN A 1 51  ? -24.20170 2.92050   31.65105 1.000 45.73803 ? 45  ASN A ND2 1 
ATOM   286  N N   . LYS A 1 52  ? -29.38825 5.56845   31.68752 1.000 42.43537 ? 46  LYS A N   1 
ATOM   287  C CA  . LYS A 1 52  ? -30.54648 6.22282   32.30631 1.000 40.52831 ? 46  LYS A CA  1 
ATOM   288  C C   . LYS A 1 52  ? -30.26518 6.60171   33.76311 1.000 40.51935 ? 46  LYS A C   1 
ATOM   289  O O   . LYS A 1 52  ? -31.07759 6.38126   34.66155 1.000 41.56885 ? 46  LYS A O   1 
ATOM   290  C CB  . LYS A 1 52  ? -31.79233 5.33581   32.19302 1.000 41.39165 ? 46  LYS A CB  1 
ATOM   291  C CG  . LYS A 1 52  ? -32.60212 5.62500   30.96544 0.886 44.20539 ? 46  LYS A CG  1 
ATOM   292  C CD  . LYS A 1 52  ? -32.19738 4.67375   29.84805 0.300 45.40878 ? 46  LYS A CD  1 
ATOM   293  C CE  . LYS A 1 52  ? -32.79721 5.05380   28.48785 0.812 46.08906 ? 46  LYS A CE  1 
ATOM   294  N NZ  . LYS A 1 52  ? -32.39676 4.01497   27.47669 0.484 46.69450 ? 46  LYS A NZ  1 
ATOM   295  N N   . VAL A 1 53  ? -29.08288 7.15000   34.00592 1.000 40.02791 ? 47  VAL A N   1 
ATOM   296  C CA  . VAL A 1 53  ? -28.64626 7.53741   35.33623 1.000 38.63951 ? 47  VAL A CA  1 
ATOM   297  C C   . VAL A 1 53  ? -27.73456 8.73867   35.17134 1.000 34.81077 ? 47  VAL A C   1 
ATOM   298  O O   . VAL A 1 53  ? -27.19394 8.97482   34.09160 1.000 34.42114 ? 47  VAL A O   1 
ATOM   299  C CB  . VAL A 1 53  ? -27.94698 6.34420   36.02979 1.000 41.49008 ? 47  VAL A CB  1 
ATOM   300  C CG1 . VAL A 1 53  ? -26.58413 6.12535   35.46598 1.000 41.82704 ? 47  VAL A CG1 1 
ATOM   301  C CG2 . VAL A 1 53  ? -27.88161 6.56370   37.51611 1.000 43.33799 ? 47  VAL A CG2 1 
ATOM   302  N N   . ARG A 1 54  ? -27.61216 9.54984   36.21710 1.000 31.99237 ? 48  ARG A N   1 
ATOM   303  C CA  . ARG A 1 54  ? -26.60978 10.60465  36.13592 1.000 30.96190 ? 48  ARG A CA  1 
ATOM   304  C C   . ARG A 1 54  ? -25.24762 10.04404  36.53786 1.000 29.60291 ? 48  ARG A C   1 
ATOM   305  O O   . ARG A 1 54  ? -25.14463 9.10465   37.33850 1.000 29.29804 ? 48  ARG A O   1 
ATOM   306  C CB  . ARG A 1 54  ? -26.99167 11.81445  36.99306 1.000 31.88767 ? 48  ARG A CB  1 
ATOM   307  C CG  . ARG A 1 54  ? -28.15378 12.66325  36.35844 1.000 33.54860 ? 48  ARG A CG  1 
ATOM   308  C CD  . ARG A 1 54  ? -28.44428 13.97266  37.10506 1.000 35.21190 ? 48  ARG A CD  1 
ATOM   309  N NE  . ARG A 1 54  ? -27.44977 15.01318  36.86760 1.000 35.81179 ? 48  ARG A NE  1 
ATOM   310  C CZ  . ARG A 1 54  ? -27.40035 15.76469  35.77979 1.000 36.40006 ? 48  ARG A CZ  1 
ATOM   311  N NH1 . ARG A 1 54  ? -28.28510 15.62221  34.80318 1.000 37.26297 ? 48  ARG A NH1 1 
ATOM   312  N NH2 . ARG A 1 54  ? -26.44233 16.68429  35.66785 1.000 36.36396 ? 48  ARG A NH2 1 
ATOM   313  N N   . VAL A 1 55  ? -24.19387 10.62609  35.94705 1.000 26.78965 ? 49  VAL A N   1 
ATOM   314  C CA  . VAL A 1 55  ? -22.81090 10.19272  36.10537 1.000 25.41706 ? 49  VAL A CA  1 
ATOM   315  C C   . VAL A 1 55  ? -21.94211 11.42274  36.33742 1.000 24.29479 ? 49  VAL A C   1 
ATOM   316  O O   . VAL A 1 55  ? -22.37584 12.55966  36.14579 1.000 25.30048 ? 49  VAL A O   1 
ATOM   317  C CB  . VAL A 1 55  ? -22.30230 9.42458   34.87421 1.000 23.85459 ? 49  VAL A CB  1 
ATOM   318  C CG1 . VAL A 1 55  ? -23.10531 8.15500   34.64419 1.000 24.90515 ? 49  VAL A CG1 1 
ATOM   319  C CG2 . VAL A 1 55  ? -22.37825 10.36066  33.60693 1.000 25.49976 ? 49  VAL A CG2 1 
ATOM   320  N N   . ALA A 1 56  ? -20.69474 11.18426  36.72721 1.000 22.92697 ? 50  ALA A N   1 
ATOM   321  C CA  . ALA A 1 56  ? -19.69310 12.25202  36.80893 1.000 21.89485 ? 50  ALA A CA  1 
ATOM   322  C C   . ALA A 1 56  ? -18.78832 12.17539  35.59357 1.000 22.30238 ? 50  ALA A C   1 
ATOM   323  O O   . ALA A 1 56  ? -18.48887 11.07859  35.10893 1.000 23.40314 ? 50  ALA A O   1 
ATOM   324  C CB  . ALA A 1 56  ? -18.83596 12.14322  38.07846 1.000 22.33312 ? 50  ALA A CB  1 
ATOM   325  N N   . ILE A 1 57  ? -18.35425 13.33395  35.08908 1.000 21.20606 ? 51  ILE A N   1 
ATOM   326  C CA  . ILE A 1 57  ? -17.45319 13.39051  33.93536 1.000 22.01726 ? 51  ILE A CA  1 
ATOM   327  C C   . ILE A 1 57  ? -16.33589 14.38332  34.23260 1.000 22.77535 ? 51  ILE A C   1 
ATOM   328  O O   . ILE A 1 57  ? -16.60135 15.56305  34.52020 1.000 24.90870 ? 51  ILE A O   1 
ATOM   329  C CB  . ILE A 1 57  ? -18.17898 13.80340  32.64582 1.000 22.37197 ? 51  ILE A CB  1 
ATOM   330  C CG1 . ILE A 1 57  ? -19.38854 12.88965  32.40698 1.000 22.86281 ? 51  ILE A CG1 1 
ATOM   331  C CG2 . ILE A 1 57  ? -17.15872 13.74780  31.47002 1.000 22.83125 ? 51  ILE A CG2 1 
ATOM   332  C CD1 . ILE A 1 57  ? -20.17376 13.16224  31.11285 1.000 24.14374 ? 51  ILE A CD1 1 
ATOM   333  N N   . LYS A 1 58  ? -15.09220 13.92634  34.10276 1.000 22.01082 ? 52  LYS A N   1 
ATOM   334  C CA  . LYS A 1 58  ? -13.91481 14.74225  34.33024 1.000 23.31092 ? 52  LYS A CA  1 
ATOM   335  C C   . LYS A 1 58  ? -13.31864 15.09554  32.96799 1.000 23.83444 ? 52  LYS A C   1 
ATOM   336  O O   . LYS A 1 58  ? -13.00398 14.19476  32.18100 1.000 24.20194 ? 52  LYS A O   1 
ATOM   337  C CB  . LYS A 1 58  ? -12.88804 13.97866  35.18018 1.000 26.02747 ? 52  LYS A CB  1 
ATOM   338  C CG  . LYS A 1 58  ? -11.63154 14.76986  35.52336 1.000 28.77651 ? 52  LYS A CG  1 
ATOM   339  C CD  . LYS A 1 58  ? -10.74734 13.96462  36.54400 1.000 29.87326 ? 52  LYS A CD  1 
ATOM   340  C CE  . LYS A 1 58  ? -10.17349 12.63084  35.97458 1.000 30.30635 ? 52  LYS A CE  1 
ATOM   341  N NZ  . LYS A 1 58  ? -9.07202  12.09677  36.85673 1.000 32.46258 ? 52  LYS A NZ  1 
ATOM   342  N N   . LYS A 1 59  ? -13.13948 16.39192  32.69705 1.000 25.50219 ? 53  LYS A N   1 
ATOM   343  C CA  . LYS A 1 59  ? -12.49153 16.81566  31.46071 1.000 27.61064 ? 53  LYS A CA  1 
ATOM   344  C C   . LYS A 1 59  ? -10.99514 16.95513  31.73373 1.000 29.52634 ? 53  LYS A C   1 
ATOM   345  O O   . LYS A 1 59  ? -10.58513 17.48094  32.78191 1.000 31.90937 ? 53  LYS A O   1 
ATOM   346  C CB  . LYS A 1 59  ? -13.08766 18.12897  30.92988 1.000 30.05837 ? 53  LYS A CB  1 
ATOM   347  C CG  . LYS A 1 59  ? -12.30460 18.79754  29.82452 1.000 31.01938 ? 53  LYS A CG  1 
ATOM   348  C CD  . LYS A 1 59  ? -12.96922 20.11433  29.41555 1.000 33.77459 ? 53  LYS A CD  1 
ATOM   349  C CE  . LYS A 1 59  ? -12.53850 20.55392  28.01939 1.000 36.69768 ? 53  LYS A CE  1 
ATOM   350  N NZ  . LYS A 1 59  ? -12.63303 22.05557  27.80089 1.000 39.22859 ? 53  LYS A NZ  1 
ATOM   351  N N   . ILE A 1 60  ? -10.18482 16.43319  30.81586 1.000 26.79658 ? 54  ILE A N   1 
ATOM   352  C CA  . ILE A 1 60  ? -8.73545  16.43576  30.94040 1.000 28.30735 ? 54  ILE A CA  1 
ATOM   353  C C   . ILE A 1 60  ? -8.17366  17.06605  29.68111 1.000 29.88058 ? 54  ILE A C   1 
ATOM   354  O O   . ILE A 1 60  ? -8.47083  16.59000  28.58302 1.000 28.30097 ? 54  ILE A O   1 
ATOM   355  C CB  . ILE A 1 60  ? -8.18475  15.00824  31.08237 1.000 27.49419 ? 54  ILE A CB  1 
ATOM   356  C CG1 . ILE A 1 60  ? -8.94054  14.23494  32.15762 1.000 28.14025 ? 54  ILE A CG1 1 
ATOM   357  C CG2 . ILE A 1 60  ? -6.65093  15.06527  31.42295 1.000 29.02928 ? 54  ILE A CG2 1 
ATOM   358  C CD1 . ILE A 1 60  ? -8.44586  12.80297  32.31585 1.000 29.82310 ? 54  ILE A CD1 1 
ATOM   359  N N   . SER A 1 61  ? -7.33477  18.10398  29.82896 1.000 32.93899 ? 55  SER A N   1 
ATOM   360  C CA  . SER A 1 61  ? -6.66294  18.73682  28.69290 1.000 34.25791 ? 55  SER A CA  1 
ATOM   361  C C   . SER A 1 61  ? -5.16008  18.67560  28.95269 1.000 37.21521 ? 55  SER A C   1 
ATOM   362  O O   . SER A 1 61  ? -4.55514  19.65437  29.41374 1.000 39.39092 ? 55  SER A O   1 
ATOM   363  C CB  . SER A 1 61  ? -7.14989  20.17098  28.48127 1.000 36.53847 ? 55  SER A CB  1 
ATOM   364  O OG  . SER A 1 61  ? -8.55988  20.18144  28.24037 1.000 38.55177 ? 55  SER A OG  1 
ATOM   365  N N   . PRO A 1 62  ? -4.53554  17.52511  28.70906 1.000 37.12478 ? 56  PRO A N   1 
ATOM   366  C CA  . PRO A 1 62  ? -3.15468  17.32902  29.14890 1.000 38.93673 ? 56  PRO A CA  1 
ATOM   367  C C   . PRO A 1 62  ? -2.10676  17.55645  28.08741 1.000 39.71606 ? 56  PRO A C   1 
ATOM   368  O O   . PRO A 1 62  ? -0.92400  17.56022  28.43249 1.000 40.50611 ? 56  PRO A O   1 
ATOM   369  C CB  . PRO A 1 62  ? -3.14714  15.85135  29.55196 1.000 38.43585 ? 56  PRO A CB  1 
ATOM   370  C CG  . PRO A 1 62  ? -4.01805  15.24132  28.46877 1.000 38.06767 ? 56  PRO A CG  1 
ATOM   371  C CD  . PRO A 1 62  ? -5.12719  16.26502  28.20796 1.000 37.36489 ? 56  PRO A CD  1 
ATOM   372  N N   . PHE A 1 63  ? -2.48433  17.71648  26.81009 1.000 40.38560 ? 57  PHE A N   1 
ATOM   373  C CA  . PHE A 1 63  ? -1.52440  17.39892  25.75552 1.000 41.97427 ? 57  PHE A CA  1 
ATOM   374  C C   . PHE A 1 63  ? -0.45702  18.44146  25.51863 1.000 45.96397 ? 57  PHE A C   1 
ATOM   375  O O   . PHE A 1 63  ? 0.48040   18.13825  24.77375 1.000 47.64185 ? 57  PHE A O   1 
ATOM   376  C CB  . PHE A 1 63  ? -2.22816  17.07863  24.43002 1.000 40.17160 ? 57  PHE A CB  1 
ATOM   377  C CG  . PHE A 1 63  ? -3.28092  16.01921  24.57535 1.000 36.43565 ? 57  PHE A CG  1 
ATOM   378  C CD1 . PHE A 1 63  ? -2.87476  14.73267  24.90706 1.000 37.00053 ? 57  PHE A CD1 1 
ATOM   379  C CD2 . PHE A 1 63  ? -4.64108  16.28229  24.40328 1.000 33.87139 ? 57  PHE A CD2 1 
ATOM   380  C CE1 . PHE A 1 63  ? -3.77450  13.71297  25.10322 1.000 35.95578 ? 57  PHE A CE1 1 
ATOM   381  C CE2 . PHE A 1 63  ? -5.56539  15.23927  24.57413 1.000 36.31600 ? 57  PHE A CE2 1 
ATOM   382  C CZ  . PHE A 1 63  ? -5.12286  13.95528  24.93136 1.000 35.71741 ? 57  PHE A CZ  1 
ATOM   383  N N   . GLU A 1 64  ? -0.54517  19.60864  26.15734 1.000 47.08444 ? 58  GLU A N   1 
ATOM   384  C CA  . GLU A 1 64  ? 0.51270   20.62131  26.02757 1.000 48.64957 ? 58  GLU A CA  1 
ATOM   385  C C   . GLU A 1 64  ? 1.74365   20.25705  26.84408 1.000 49.46676 ? 58  GLU A C   1 
ATOM   386  O O   . GLU A 1 64  ? 2.87265   20.62190  26.47614 1.000 51.03425 ? 58  GLU A O   1 
ATOM   387  C CB  . GLU A 1 64  ? -0.01364  21.97510  26.49209 0.534 48.81388 ? 58  GLU A CB  1 
ATOM   388  C CG  . GLU A 1 64  ? -1.02393  22.64265  25.57856 0.934 48.64999 ? 58  GLU A CG  1 
ATOM   389  C CD  . GLU A 1 64  ? -0.60254  22.62046  24.12012 0.689 49.16431 ? 58  GLU A CD  1 
ATOM   390  O OE1 . GLU A 1 64  ? 0.49569   23.13429  23.82357 0.356 49.47491 ? 58  GLU A OE1 1 
ATOM   391  O OE2 . GLU A 1 64  ? -1.37767  22.12225  23.27534 0.500 49.59755 ? 58  GLU A OE2 1 
ATOM   392  N N   . HIS A 1 65  ? 1.54462   19.59404  27.98442 1.000 51.19000 ? 59  HIS A N   1 
ATOM   393  C CA  . HIS A 1 65  ? 2.59814   19.36823  28.96354 1.000 51.59783 ? 59  HIS A CA  1 
ATOM   394  C C   . HIS A 1 65  ? 2.86861   17.88806  29.17813 1.000 50.46227 ? 59  HIS A C   1 
ATOM   395  O O   . HIS A 1 65  ? 1.94279   17.08541  29.37857 1.000 49.42299 ? 59  HIS A O   1 
ATOM   396  C CB  . HIS A 1 65  ? 2.28071   20.04631  30.29369 1.000 52.83566 ? 59  HIS A CB  1 
ATOM   397  C CG  . HIS A 1 65  ? 2.24011   21.53960  30.20301 0.508 53.76302 ? 59  HIS A CG  1 
ATOM   398  N ND1 . HIS A 1 65  ? 1.18558   22.29451  30.67034 0.552 54.09133 ? 59  HIS A ND1 1 
ATOM   399  C CD2 . HIS A 1 65  ? 3.11268   22.41487  29.64694 0.963 54.51253 ? 59  HIS A CD2 1 
ATOM   400  C CE1 . HIS A 1 65  ? 1.42919   23.57369  30.44269 0.614 54.24152 ? 59  HIS A CE1 1 
ATOM   401  N NE2 . HIS A 1 65  ? 2.58613   23.67305  29.81282 0.586 54.34848 ? 59  HIS A NE2 1 
ATOM   402  N N   . GLN A 1 66  ? 4.16437   17.55783  29.16190 1.000 49.78400 ? 60  GLN A N   1 
ATOM   403  C CA  . GLN A 1 66  ? 4.60831   16.17017  29.23065 1.000 48.77056 ? 60  GLN A CA  1 
ATOM   404  C C   . GLN A 1 66  ? 4.19420   15.52200  30.54349 1.000 48.15238 ? 60  GLN A C   1 
ATOM   405  O O   . GLN A 1 66  ? 3.72112   14.37570  30.55516 1.000 48.54923 ? 60  GLN A O   1 
ATOM   406  C CB  . GLN A 1 66  ? 6.13226   16.11036  29.06923 1.000 49.53744 ? 60  GLN A CB  1 
ATOM   407  C CG  . GLN A 1 66  ? 6.63470   14.74613  28.66664 1.000 51.17212 ? 60  GLN A CG  1 
ATOM   408  C CD  . GLN A 1 66  ? 7.29153   14.01569  29.78808 0.899 54.30160 ? 60  GLN A CD  1 
ATOM   409  O OE1 . GLN A 1 66  ? 7.59140   14.59343  30.83013 0.514 55.86607 ? 60  GLN A OE1 1 
ATOM   410  N NE2 . GLN A 1 66  ? 7.53794   12.72703  29.58114 0.650 54.25871 ? 60  GLN A NE2 1 
ATOM   411  N N   . THR A 1 67  ? 4.35602   16.24230  31.66297 1.000 48.74955 ? 61  THR A N   1 
ATOM   412  C CA  . THR A 1 67  ? 4.02216   15.65578  32.96567 1.000 48.44777 ? 61  THR A CA  1 
ATOM   413  C C   . THR A 1 67  ? 2.52173   15.41665  33.05325 1.000 45.58361 ? 61  THR A C   1 
ATOM   414  O O   . THR A 1 67  ? 2.07638   14.42493  33.64196 1.000 44.66343 ? 61  THR A O   1 
ATOM   415  C CB  . THR A 1 67  ? 4.43287   16.56453  34.13449 1.000 48.77625 ? 61  THR A CB  1 
ATOM   416  O OG1 . THR A 1 67  ? 4.18747   17.93136  33.79135 1.000 51.28868 ? 61  THR A OG1 1 
ATOM   417  C CG2 . THR A 1 67  ? 5.95274   16.44303  34.43530 1.000 49.02928 ? 61  THR A CG2 1 
ATOM   418  N N   . TYR A 1 68  ? 1.72857   16.33177  32.48536 1.000 44.36946 ? 62  TYR A N   1 
ATOM   419  C CA  . TYR A 1 68  ? 0.27384   16.14489  32.45886 1.000 42.28788 ? 62  TYR A CA  1 
ATOM   420  C C   . TYR A 1 68  ? -0.09984  14.87383  31.71885 1.000 40.47327 ? 62  TYR A C   1 
ATOM   421  O O   . TYR A 1 68  ? -0.96105  14.10906  32.17293 1.000 39.31153 ? 62  TYR A O   1 
ATOM   422  C CB  . TYR A 1 68  ? -0.42430  17.33045  31.79443 1.000 44.13716 ? 62  TYR A CB  1 
ATOM   423  C CG  . TYR A 1 68  ? -0.32514  18.68926  32.46439 0.511 44.77424 ? 62  TYR A CG  1 
ATOM   424  C CD1 . TYR A 1 68  ? 0.54201   18.92590  33.51810 0.535 44.65628 ? 62  TYR A CD1 1 
ATOM   425  C CD2 . TYR A 1 68  ? -1.12322  19.74501  32.02074 0.807 45.50094 ? 62  TYR A CD2 1 
ATOM   426  C CE1 . TYR A 1 68  ? 0.61006   20.17753  34.11655 0.548 45.11193 ? 62  TYR A CE1 1 
ATOM   427  C CE2 . TYR A 1 68  ? -1.06114  20.98673  32.60715 0.739 45.92624 ? 62  TYR A CE2 1 
ATOM   428  C CZ  . TYR A 1 68  ? -0.19696  21.20029  33.65532 0.982 45.57356 ? 62  TYR A CZ  1 
ATOM   429  O OH  . TYR A 1 68  ? -0.13592  22.44951  34.22502 0.325 46.19849 ? 62  TYR A OH  1 
ATOM   430  N N   . CYS A 1 69  ? 0.49957   14.65847  30.54369 1.000 40.06991 ? 63  CYS A N   1 
ATOM   431  C CA  . CYS A 1 69  ? 0.21953   13.44235  29.78734 1.000 39.93292 ? 63  CYS A CA  1 
ATOM   432  C C   . CYS A 1 69  ? 0.66951   12.20992  30.53736 1.000 37.25389 ? 63  CYS A C   1 
ATOM   433  O O   . CYS A 1 69  ? 0.00702   11.16280  30.45392 1.000 35.78835 ? 63  CYS A O   1 
ATOM   434  C CB  . CYS A 1 69  ? 0.86938   13.47331  28.40230 1.000 41.60640 ? 63  CYS A CB  1 
ATOM   435  S SG  . CYS A 1 69  ? 0.33641   14.82983  27.39625 1.000 43.46053 ? 63  CYS A SG  1 
ATOM   436  N N   . GLN A 1 70  ? 1.78608   12.30811  31.27198 1.000 36.26191 ? 64  GLN A N   1 
ATOM   437  C CA  . GLN A 1 70  ? 2.22964   11.18431  32.09053 1.000 36.36202 ? 64  GLN A CA  1 
ATOM   438  C C   . GLN A 1 70  ? 1.17389   10.80511  33.11887 1.000 34.28973 ? 64  GLN A C   1 
ATOM   439  O O   . GLN A 1 70  ? 0.79384   9.63659   33.23916 1.000 34.19983 ? 64  GLN A O   1 
ATOM   440  C CB  . GLN A 1 70  ? 3.53899   11.50729  32.82272 0.970 38.65342 ? 64  GLN A CB  1 
ATOM   441  C CG  . GLN A 1 70  ? 4.80643   10.86156  32.29262 0.283 40.88431 ? 64  GLN A CG  1 
ATOM   442  C CD  . GLN A 1 70  ? 6.02815   11.75619  32.39948 0.543 42.21271 ? 64  GLN A CD  1 
ATOM   443  O OE1 . GLN A 1 70  ? 6.01926   12.76907  33.10547 0.450 42.40984 ? 64  GLN A OE1 1 
ATOM   444  N NE2 . GLN A 1 70  ? 7.12845   11.31486  31.80215 0.417 43.42084 ? 64  GLN A NE2 1 
ATOM   445  N N   . ARG A 1 71  ? 0.71996   11.79319  33.88866 1.000 33.11691 ? 65  ARG A N   1 
ATOM   446  C CA  . ARG A 1 71  ? -0.25806  11.58074  34.94945 1.000 33.87118 ? 65  ARG A CA  1 
ATOM   447  C C   . ARG A 1 71  ? -1.54690  10.99544  34.38219 1.000 31.28555 ? 65  ARG A C   1 
ATOM   448  O O   . ARG A 1 71  ? -2.11267  10.04765  34.94392 1.000 31.41435 ? 65  ARG A O   1 
ATOM   449  C CB  . ARG A 1 71  ? -0.49014  12.93158  35.63561 1.000 36.51013 ? 65  ARG A CB  1 
ATOM   450  C CG  . ARG A 1 71  ? -1.52537  12.98042  36.77213 1.000 38.17418 ? 65  ARG A CG  1 
ATOM   451  C CD  A ARG A 1 71  ? -1.13783  14.19050  37.66366 0.388 38.50998 ? 65  ARG A CD  1 
ATOM   452  C CD  B ARG A 1 71  ? -1.55003  14.28476  37.59956 0.612 38.21961 ? 65  ARG A CD  1 
ATOM   453  N NE  A ARG A 1 71  ? 0.30917   14.24441  37.89231 0.388 38.45621 ? 65  ARG A NE  1 
ATOM   454  N NE  B ARG A 1 71  ? -2.65905  14.25972  38.54962 0.612 37.37722 ? 65  ARG A NE  1 
ATOM   455  C CZ  A ARG A 1 71  ? 0.98011   15.29074  38.36721 0.388 37.77689 ? 65  ARG A CZ  1 
ATOM   456  C CZ  B ARG A 1 71  ? -2.77862  15.04998  39.61120 0.612 37.12770 ? 65  ARG A CZ  1 
ATOM   457  N NH1 A ARG A 1 71  ? 0.38139   16.44329  38.62448 0.388 38.25183 ? 65  ARG A NH1 1 
ATOM   458  N NH1 B ARG A 1 71  ? -1.85014  15.95330  39.91613 0.612 37.55923 ? 65  ARG A NH1 1 
ATOM   459  N NH2 A ARG A 1 71  ? 2.28793   15.17636  38.59256 0.388 35.30544 ? 65  ARG A NH2 1 
ATOM   460  N NH2 B ARG A 1 71  ? -3.85032  14.92360  40.39675 0.612 35.24608 ? 65  ARG A NH2 1 
ATOM   461  N N   . THR A 1 72  ? -1.98667  11.51795  33.23370 1.000 28.89290 ? 66  THR A N   1 
ATOM   462  C CA  . THR A 1 72  ? -3.21417  11.04912  32.60756 1.000 27.77904 ? 66  THR A CA  1 
ATOM   463  C C   . THR A 1 72  ? -3.09751  9.60257   32.17577 1.000 26.23700 ? 66  THR A C   1 
ATOM   464  O O   . THR A 1 72  ? -4.00907  8.79009   32.39051 1.000 23.82808 ? 66  THR A O   1 
ATOM   465  C CB  . THR A 1 72  ? -3.52078  11.92019  31.38854 1.000 28.23903 ? 66  THR A CB  1 
ATOM   466  O OG1 . THR A 1 72  ? -3.67978  13.27230  31.81344 1.000 29.93158 ? 66  THR A OG1 1 
ATOM   467  C CG2 . THR A 1 72  ? -4.73905  11.41672  30.63090 1.000 27.39292 ? 66  THR A CG2 1 
ATOM   468  N N   . LEU A 1 73  ? -2.00916  9.29218   31.48830 1.000 26.64003 ? 67  LEU A N   1 
ATOM   469  C CA  . LEU A 1 73  ? -1.79872  7.94595   30.99701 1.000 28.45606 ? 67  LEU A CA  1 
ATOM   470  C C   . LEU A 1 73  ? -1.67014  6.96017   32.15259 1.000 27.88628 ? 67  LEU A C   1 
ATOM   471  O O   . LEU A 1 73  ? -2.27270  5.89017   32.12633 1.000 26.53523 ? 67  LEU A O   1 
ATOM   472  C CB  . LEU A 1 73  ? -0.55858  7.91747   30.09807 1.000 29.22541 ? 67  LEU A CB  1 
ATOM   473  C CG  . LEU A 1 73  ? -0.24157  6.53383   29.56418 1.000 29.63953 ? 67  LEU A CG  1 
ATOM   474  C CD1 . LEU A 1 73  ? -1.39878  6.01475   28.74756 1.000 29.94495 ? 67  LEU A CD1 1 
ATOM   475  C CD2 . LEU A 1 73  ? 1.02363   6.62946   28.70267 1.000 31.54284 ? 67  LEU A CD2 1 
ATOM   476  N N   . ARG A 1 74  ? -0.89784  7.30326   33.17988 1.000 28.82424 ? 68  ARG A N   1 
ATOM   477  C CA  . ARG A 1 74  ? -0.73987  6.32997   34.26075 1.000 28.98228 ? 68  ARG A CA  1 
ATOM   478  C C   . ARG A 1 74  ? -2.07544  6.06002   34.97621 1.000 26.63636 ? 68  ARG A C   1 
ATOM   479  O O   . ARG A 1 74  ? -2.37355  4.90263   35.32625 1.000 26.77309 ? 68  ARG A O   1 
ATOM   480  C CB  . ARG A 1 74  ? 0.37341   6.76118   35.20363 0.989 33.49885 ? 68  ARG A CB  1 
ATOM   481  C CG  . ARG A 1 74  ? 0.01783   7.61378   36.36140 0.654 35.57236 ? 68  ARG A CG  1 
ATOM   482  C CD  . ARG A 1 74  ? 1.29174   7.74779   37.19022 0.454 37.56554 ? 68  ARG A CD  1 
ATOM   483  N NE  . ARG A 1 74  ? 2.09571   8.88604   36.76947 0.733 38.72146 ? 68  ARG A NE  1 
ATOM   484  C CZ  . ARG A 1 74  ? 3.36932   8.81101   36.40885 0.822 39.50607 ? 68  ARG A CZ  1 
ATOM   485  N NH1 . ARG A 1 74  ? 4.01622   7.65825   36.39462 0.679 40.71481 ? 68  ARG A NH1 1 
ATOM   486  N NH2 . ARG A 1 74  ? 4.00595   9.92006   36.04636 0.585 39.35582 ? 68  ARG A NH2 1 
ATOM   487  N N   . GLU A 1 75  ? -2.92813  7.08479   35.14572 1.000 23.28284 ? 69  GLU A N   1 
ATOM   488  C CA  . GLU A 1 75  ? -4.21619  6.82591   35.79064 1.000 22.57089 ? 69  GLU A CA  1 
ATOM   489  C C   . GLU A 1 75  ? -5.08833  5.92248   34.94467 1.000 20.37977 ? 69  GLU A C   1 
ATOM   490  O O   . GLU A 1 75  ? -5.75446  5.01720   35.46364 1.000 21.08837 ? 69  GLU A O   1 
ATOM   491  C CB  . GLU A 1 75  ? -4.97299  8.11669   36.08131 1.000 24.31956 ? 69  GLU A CB  1 
ATOM   492  C CG  . GLU A 1 75  ? -6.42916  7.83403   36.46328 1.000 25.04009 ? 69  GLU A CG  1 
ATOM   493  C CD  . GLU A 1 75  ? -7.13611  9.03964   37.03602 1.000 28.67346 ? 69  GLU A CD  1 
ATOM   494  O OE1 . GLU A 1 75  ? -7.23247  10.07820  36.33879 1.000 31.11320 ? 69  GLU A OE1 1 
ATOM   495  O OE2 . GLU A 1 75  ? -7.58794  8.97558   38.18993 1.000 27.59491 ? 69  GLU A OE2 1 
ATOM   496  N N   . ILE A 1 76  ? -5.17282  6.21376   33.64718 1.000 20.08069 ? 70  ILE A N   1 
ATOM   497  C CA  . ILE A 1 76  ? -6.00351  5.40521   32.76016 1.000 20.17325 ? 70  ILE A CA  1 
ATOM   498  C C   . ILE A 1 76  ? -5.50226  3.96812   32.75189 1.000 20.95109 ? 70  ILE A C   1 
ATOM   499  O O   . ILE A 1 76  ? -6.28846  3.03105   32.87428 1.000 23.43015 ? 70  ILE A O   1 
ATOM   500  C CB  . ILE A 1 76  ? -6.02475  6.00715   31.34748 1.000 20.65593 ? 70  ILE A CB  1 
ATOM   501  C CG1 . ILE A 1 76  ? -6.71680  7.37979   31.38375 1.000 21.17926 ? 70  ILE A CG1 1 
ATOM   502  C CG2 . ILE A 1 76  ? -6.75029  5.05734   30.40514 1.000 22.78005 ? 70  ILE A CG2 1 
ATOM   503  C CD1 . ILE A 1 76  ? -6.63645  8.14206   30.07628 1.000 23.38363 ? 70  ILE A CD1 1 
ATOM   504  N N   . LYS A 1 77  ? -4.18528  3.77268   32.65440 1.000 21.41100 ? 71  LYS A N   1 
ATOM   505  C CA  . LYS A 1 77  ? -3.64936  2.41513   32.60428 1.000 23.20961 ? 71  LYS A CA  1 
ATOM   506  C C   . LYS A 1 77  ? -4.00522  1.65190   33.88246 1.000 24.40936 ? 71  LYS A C   1 
ATOM   507  O O   . LYS A 1 77  ? -4.46319  0.49908   33.83701 1.000 26.35856 ? 71  LYS A O   1 
ATOM   508  C CB  . LYS A 1 77  ? -2.12200  2.47554   32.42136 1.000 24.11627 ? 71  LYS A CB  1 
ATOM   509  C CG  . LYS A 1 77  ? -1.68848  2.43532   30.95817 0.635 29.06161 ? 71  LYS A CG  1 
ATOM   510  C CD  . LYS A 1 77  ? -0.16865  2.44151   30.79612 1.000 32.59567 ? 71  LYS A CD  1 
ATOM   511  C CE  . LYS A 1 77  ? 0.35085   1.17676   30.10676 0.666 35.66729 ? 71  LYS A CE  1 
ATOM   512  N NZ  . LYS A 1 77  ? -0.58159  0.59574   29.08824 0.446 36.18620 ? 71  LYS A NZ  1 
ATOM   513  N N   . ILE A 1 78  ? -3.85181  2.29508   35.03509 1.000 21.82057 ? 72  ILE A N   1 
ATOM   514  C CA  . ILE A 1 78  ? -4.12996  1.61810   36.29472 1.000 21.71527 ? 72  ILE A CA  1 
ATOM   515  C C   . ILE A 1 78  ? -5.61199  1.28532   36.40653 1.000 22.57949 ? 72  ILE A C   1 
ATOM   516  O O   . ILE A 1 78  ? -5.98516  0.15286   36.74835 1.000 22.82776 ? 72  ILE A O   1 
ATOM   517  C CB  . ILE A 1 78  ? -3.68412  2.50642   37.47428 1.000 20.22603 ? 72  ILE A CB  1 
ATOM   518  C CG1 . ILE A 1 78  ? -2.15280  2.57993   37.51868 1.000 22.48042 ? 72  ILE A CG1 1 
ATOM   519  C CG2 . ILE A 1 78  ? -4.31775  1.98840   38.76866 1.000 20.83131 ? 72  ILE A CG2 1 
ATOM   520  C CD1 . ILE A 1 78  ? -1.64898  3.61255   38.43249 1.000 22.12968 ? 72  ILE A CD1 1 
ATOM   521  N N   . LEU A 1 79  ? -6.48838  2.26799   36.11700 1.000 22.30249 ? 73  LEU A N   1 
ATOM   522  C CA  . LEU A 1 79  ? -7.91198  2.07516   36.38809 1.000 23.00328 ? 73  LEU A CA  1 
ATOM   523  C C   . LEU A 1 79  ? -8.56351  1.13766   35.40566 1.000 26.62051 ? 73  LEU A C   1 
ATOM   524  O O   . LEU A 1 79  ? -9.57533  0.49713   35.73263 1.000 28.44649 ? 73  LEU A O   1 
ATOM   525  C CB  . LEU A 1 79  ? -8.64341  3.40400   36.36801 1.000 23.42613 ? 73  LEU A CB  1 
ATOM   526  C CG  . LEU A 1 79  ? -8.36743  4.15647   37.64005 1.000 23.43691 ? 73  LEU A CG  1 
ATOM   527  C CD1 . LEU A 1 79  ? -9.14278  5.42651   37.56079 1.000 22.83556 ? 73  LEU A CD1 1 
ATOM   528  C CD2 . LEU A 1 79  ? -8.71404  3.34714   38.98615 1.000 24.69887 ? 73  LEU A CD2 1 
ATOM   529  N N   . LEU A 1 80  ? -8.02356  1.03962   34.19563 1.000 25.87894 ? 74  LEU A N   1 
ATOM   530  C CA  . LEU A 1 80  ? -8.55984  0.06755   33.27490 1.000 29.35172 ? 74  LEU A CA  1 
ATOM   531  C C   . LEU A 1 80  ? -8.21559  -1.35590  33.71200 1.000 27.96440 ? 74  LEU A C   1 
ATOM   532  O O   . LEU A 1 80  ? -8.90328  -2.29862  33.29986 1.000 31.38251 ? 74  LEU A O   1 
ATOM   533  C CB  . LEU A 1 80  ? -8.03565  0.40307   31.88876 1.000 29.83919 ? 74  LEU A CB  1 
ATOM   534  C CG  . LEU A 1 80  ? -8.72076  1.64192   31.27862 1.000 31.79781 ? 74  LEU A CG  1 
ATOM   535  C CD1 . LEU A 1 80  ? -8.38623  1.77127   29.79942 1.000 33.95915 ? 74  LEU A CD1 1 
ATOM   536  C CD2 . LEU A 1 80  ? -10.22570 1.69240   31.46883 1.000 31.94070 ? 74  LEU A CD2 1 
ATOM   537  N N   . ARG A 1 81  ? -7.19766  -1.54817  34.54808 1.000 26.09492 ? 75  ARG A N   1 
ATOM   538  C CA  A ARG A 1 81  ? -6.96866  -2.89209  35.05766 0.265 27.37886 ? 75  ARG A CA  1 
ATOM   539  C CA  B ARG A 1 81  ? -6.90009  -2.87065  35.08887 0.735 26.58952 ? 75  ARG A CA  1 
ATOM   540  C C   . ARG A 1 81  ? -7.58513  -3.14987  36.41689 1.000 26.45606 ? 75  ARG A C   1 
ATOM   541  O O   . ARG A 1 81  ? -7.95235  -4.29359  36.69260 1.000 31.35614 ? 75  ARG A O   1 
ATOM   542  C CB  A ARG A 1 81  ? -5.47691  -3.23566  35.10551 0.265 30.73128 ? 75  ARG A CB  1 
ATOM   543  C CB  B ARG A 1 81  ? -5.38670  -3.05968  35.25421 0.735 30.49154 ? 75  ARG A CB  1 
ATOM   544  C CG  A ARG A 1 81  ? -4.86475  -3.39582  33.71618 0.265 34.90004 ? 75  ARG A CG  1 
ATOM   545  C CG  B ARG A 1 81  ? -4.76841  -3.81505  34.08988 0.735 37.27327 ? 75  ARG A CG  1 
ATOM   546  C CD  A ARG A 1 81  ? -3.38468  -3.67058  33.79389 0.265 38.13258 ? 75  ARG A CD  1 
ATOM   547  C CD  B ARG A 1 81  ? -3.89844  -4.97715  34.57972 0.735 41.03692 ? 75  ARG A CD  1 
ATOM   548  N NE  A ARG A 1 81  ? -3.12133  -4.93509  34.47825 0.265 40.85242 ? 75  ARG A NE  1 
ATOM   549  N NE  B ARG A 1 81  ? -2.47591  -4.69434  34.39650 0.735 43.87092 ? 75  ARG A NE  1 
ATOM   550  C CZ  A ARG A 1 81  ? -1.91226  -5.38143  34.79374 0.265 42.24000 ? 75  ARG A CZ  1 
ATOM   551  C CZ  B ARG A 1 81  ? -1.49887  -5.32258  35.02987 0.735 44.70951 ? 75  ARG A CZ  1 
ATOM   552  N NH1 A ARG A 1 81  ? -0.81742  -4.73019  34.43135 0.265 42.76487 ? 75  ARG A NH1 1 
ATOM   553  N NH1 B ARG A 1 81  ? -1.75447  -6.18000  35.99654 0.735 45.60631 ? 75  ARG A NH1 1 
ATOM   554  N NH2 A ARG A 1 81  ? -1.79811  -6.51646  35.47593 0.265 42.82767 ? 75  ARG A NH2 1 
ATOM   555  N NH2 B ARG A 1 81  ? -0.23552  -5.08034  34.68014 0.735 44.89930 ? 75  ARG A NH2 1 
ATOM   556  N N   . PHE A 1 82  ? -7.76129  -2.14025  37.24196 1.000 21.79611 ? 76  PHE A N   1 
ATOM   557  C CA  . PHE A 1 82  ? -8.32659  -2.33851  38.58505 1.000 19.94662 ? 76  PHE A CA  1 
ATOM   558  C C   . PHE A 1 82  ? -9.83410  -2.52128  38.54353 1.000 19.69264 ? 76  PHE A C   1 
ATOM   559  O O   . PHE A 1 82  ? -10.54126 -1.85123  37.77050 1.000 22.75074 ? 76  PHE A O   1 
ATOM   560  C CB  . PHE A 1 82  ? -8.06334  -1.12492  39.44831 1.000 19.40749 ? 76  PHE A CB  1 
ATOM   561  C CG  . PHE A 1 82  ? -6.67947  -1.04889  40.00960 1.000 19.92056 ? 76  PHE A CG  1 
ATOM   562  C CD1 . PHE A 1 82  ? -5.69529  -1.98858  39.67135 1.000 20.35627 ? 76  PHE A CD1 1 
ATOM   563  C CD2 . PHE A 1 82  ? -6.36874  -0.05800  40.93490 1.000 19.56299 ? 76  PHE A CD2 1 
ATOM   564  C CE1 . PHE A 1 82  ? -4.40969  -1.89641  40.22509 1.000 19.64664 ? 76  PHE A CE1 1 
ATOM   565  C CE2 . PHE A 1 82  ? -5.09267  0.02465   41.46738 1.000 20.92423 ? 76  PHE A CE2 1 
ATOM   566  C CZ  . PHE A 1 82  ? -4.11976  -0.88829  41.12507 1.000 20.59123 ? 76  PHE A CZ  1 
ATOM   567  N N   . ARG A 1 83  ? -10.33781 -3.39799  39.39892 1.000 19.15297 ? 77  ARG A N   1 
ATOM   568  C CA  . ARG A 1 83  ? -11.78485 -3.52810  39.61649 1.000 19.64994 ? 77  ARG A CA  1 
ATOM   569  C C   . ARG A 1 83  ? -12.00390 -3.78797  41.09013 1.000 19.25330 ? 77  ARG A C   1 
ATOM   570  O O   . ARG A 1 83  ? -11.65967 -4.87203  41.56586 1.000 19.92836 ? 77  ARG A O   1 
ATOM   571  C CB  A ARG A 1 83  ? -12.40337 -4.66288  38.79341 0.486 22.96818 ? 77  ARG A CB  1 
ATOM   572  C CB  B ARG A 1 83  ? -12.43786 -4.62174  38.76217 0.514 22.71237 ? 77  ARG A CB  1 
ATOM   573  C CG  A ARG A 1 83  ? -13.92452 -4.73935  38.97474 0.486 25.27504 ? 77  ARG A CG  1 
ATOM   574  C CG  B ARG A 1 83  ? -12.03241 -4.56820  37.30797 0.514 24.62774 ? 77  ARG A CG  1 
ATOM   575  C CD  A ARG A 1 83  ? -14.55459 -5.80456  38.09377 0.486 29.28315 ? 77  ARG A CD  1 
ATOM   576  C CD  B ARG A 1 83  ? -13.19388 -3.93405  36.53388 0.514 28.28120 ? 77  ARG A CD  1 
ATOM   577  N NE  A ARG A 1 83  ? -14.40993 -7.14086  38.65707 0.486 34.24891 ? 77  ARG A NE  1 
ATOM   578  N NE  B ARG A 1 83  ? -12.97654 -3.76047  35.10014 0.514 29.79659 ? 77  ARG A NE  1 
ATOM   579  C CZ  A ARG A 1 83  ? -13.54632 -8.04824  38.22349 0.486 36.65764 ? 77  ARG A CZ  1 
ATOM   580  C CZ  B ARG A 1 83  ? -12.00488 -3.04858  34.53035 0.514 32.18468 ? 77  ARG A CZ  1 
ATOM   581  N NH1 A ARG A 1 83  ? -12.70882 -7.78809  37.23052 0.486 37.48396 ? 77  ARG A NH1 1 
ATOM   582  N NH1 B ARG A 1 83  ? -11.10753 -2.39820  35.24211 0.514 32.23427 ? 77  ARG A NH1 1 
ATOM   583  N NH2 A ARG A 1 83  ? -13.52955 -9.24920  38.79401 0.486 37.91952 ? 77  ARG A NH2 1 
ATOM   584  N NH2 B ARG A 1 83  ? -11.95100 -2.96893  33.19948 0.514 34.94922 ? 77  ARG A NH2 1 
ATOM   585  N N   . HIS A 1 84  ? -12.55112 -2.80451  41.80130 1.000 18.29971 ? 78  HIS A N   1 
ATOM   586  C CA  . HIS A 1 84  ? -12.75803 -2.97245  43.23480 1.000 18.76841 ? 78  HIS A CA  1 
ATOM   587  C C   . HIS A 1 84  ? -13.88689 -2.05823  43.70360 1.000 18.47010 ? 78  HIS A C   1 
ATOM   588  O O   . HIS A 1 84  ? -13.97431 -0.91138  43.25974 1.000 17.62865 ? 78  HIS A O   1 
ATOM   589  C CB  . HIS A 1 84  ? -11.46008 -2.66373  43.99138 1.000 16.52756 ? 78  HIS A CB  1 
ATOM   590  C CG  . HIS A 1 84  ? -11.49466 -3.05392  45.43634 1.000 15.56074 ? 78  HIS A CG  1 
ATOM   591  N ND1 . HIS A 1 84  ? -12.08587 -2.26904  46.40749 1.000 16.45188 ? 78  HIS A ND1 1 
ATOM   592  C CD2 . HIS A 1 84  ? -11.05121 -4.16481  46.06296 1.000 15.29880 ? 78  HIS A CD2 1 
ATOM   593  C CE1 . HIS A 1 84  ? -11.98497 -2.87470  47.58194 1.000 15.22572 ? 78  HIS A CE1 1 
ATOM   594  N NE2 . HIS A 1 84  ? -11.33498 -4.02397  47.39869 1.000 14.88637 ? 78  HIS A NE2 1 
ATOM   595  N N   . GLU A 1 85  ? -14.70870 -2.55168  44.64271 1.000 17.33427 ? 79  GLU A N   1 
ATOM   596  C CA  . GLU A 1 85  ? -15.84907 -1.76797  45.14335 1.000 17.17305 ? 79  GLU A CA  1 
ATOM   597  C C   . GLU A 1 85  ? -15.43837 -0.42921  45.75391 1.000 16.52857 ? 79  GLU A C   1 
ATOM   598  O O   . GLU A 1 85  ? -16.21299 0.53076   45.70847 1.000 18.54777 ? 79  GLU A O   1 
ATOM   599  C CB  . GLU A 1 85  ? -16.65237 -2.55991  46.19934 1.000 19.15807 ? 79  GLU A CB  1 
ATOM   600  C CG  . GLU A 1 85  ? -17.40818 -3.77956  45.63120 0.732 21.79362 ? 79  GLU A CG  1 
ATOM   601  C CD  . GLU A 1 85  ? -18.13199 -4.55759  46.71679 0.627 25.96469 ? 79  GLU A CD  1 
ATOM   602  O OE1 . GLU A 1 85  ? -17.89349 -4.29046  47.92293 0.839 28.05254 ? 79  GLU A OE1 1 
ATOM   603  O OE2 . GLU A 1 85  ? -19.04580 -5.33054  46.36232 0.664 29.41773 ? 79  GLU A OE2 1 
ATOM   604  N N   . ASN A 1 86  ? -14.23406 -0.32377  46.31923 1.000 13.99070 ? 80  ASN A N   1 
ATOM   605  C CA  . ASN A 1 86  ? -13.83161 0.91528   46.98556 1.000 13.24730 ? 80  ASN A CA  1 
ATOM   606  C C   . ASN A 1 86  ? -12.84455 1.72450   46.15370 1.000 14.78658 ? 80  ASN A C   1 
ATOM   607  O O   . ASN A 1 86  ? -12.11656 2.57335   46.69944 1.000 14.51568 ? 80  ASN A O   1 
ATOM   608  C CB  . ASN A 1 86  ? -13.22958 0.60159   48.35958 1.000 14.83800 ? 80  ASN A CB  1 
ATOM   609  C CG  . ASN A 1 86  ? -14.18470 -0.13973  49.24633 1.000 14.58023 ? 80  ASN A CG  1 
ATOM   610  O OD1 . ASN A 1 86  ? -13.92363 -1.30588  49.65199 1.000 15.73154 ? 80  ASN A OD1 1 
ATOM   611  N ND2 . ASN A 1 86  ? -15.31659 0.49954   49.55030 1.000 14.84753 ? 80  ASN A ND2 1 
ATOM   612  N N   . ILE A 1 87  ? -12.83779 1.49918   44.83839 1.000 14.67099 ? 81  ILE A N   1 
ATOM   613  C CA  . ILE A 1 87  ? -12.04429 2.28174   43.90540 1.000 15.19363 ? 81  ILE A CA  1 
ATOM   614  C C   . ILE A 1 87  ? -12.97620 2.74653   42.80830 1.000 16.19348 ? 81  ILE A C   1 
ATOM   615  O O   . ILE A 1 87  ? -13.68481 1.92037   42.20154 1.000 16.64374 ? 81  ILE A O   1 
ATOM   616  C CB  . ILE A 1 87  ? -10.87702 1.46136   43.30723 1.000 14.46360 ? 81  ILE A CB  1 
ATOM   617  C CG1 . ILE A 1 87  ? -9.93205  0.97543   44.42610 1.000 14.53150 ? 81  ILE A CG1 1 
ATOM   618  C CG2 . ILE A 1 87  ? -10.12776 2.28799   42.21942 1.000 16.35126 ? 81  ILE A CG2 1 
ATOM   619  C CD1 . ILE A 1 87  ? -8.82340  0.07187   43.92728 1.000 16.89769 ? 81  ILE A CD1 1 
ATOM   620  N N   . ILE A 1 88  ? -12.99101 4.05018   42.52659 1.000 15.93072 ? 82  ILE A N   1 
ATOM   621  C CA  . ILE A 1 88  ? -13.96150 4.48162   41.53261 1.000 17.90343 ? 82  ILE A CA  1 
ATOM   622  C C   . ILE A 1 88  ? -13.38003 4.20286   40.14644 1.000 19.74279 ? 82  ILE A C   1 
ATOM   623  O O   . ILE A 1 88  ? -12.24149 4.58578   39.82300 1.000 22.97363 ? 82  ILE A O   1 
ATOM   624  C CB  . ILE A 1 88  ? -14.39814 5.94516   41.73366 1.000 20.59206 ? 82  ILE A CB  1 
ATOM   625  C CG1 . ILE A 1 88  ? -15.50309 6.30691   40.71376 1.000 19.93742 ? 82  ILE A CG1 1 
ATOM   626  C CG2 . ILE A 1 88  ? -13.23530 6.93524   41.65338 1.000 21.08394 ? 82  ILE A CG2 1 
ATOM   627  C CD1 . ILE A 1 88  ? -16.29994 7.61574   41.07219 1.000 21.58806 ? 82  ILE A CD1 1 
ATOM   628  N N   . GLY A 1 89  ? -14.10879 3.42692   39.36910 1.000 17.86408 ? 83  GLY A N   1 
ATOM   629  C CA  . GLY A 1 89  ? -13.60424 2.96217   38.10437 1.000 17.88293 ? 83  GLY A CA  1 
ATOM   630  C C   . GLY A 1 89  ? -13.89725 3.92988   36.96850 1.000 20.48691 ? 83  GLY A C   1 
ATOM   631  O O   . GLY A 1 89  ? -14.55677 4.95502   37.11883 1.000 21.39697 ? 83  GLY A O   1 
ATOM   632  N N   . ILE A 1 90  ? -13.41769 3.56606   35.79158 1.000 19.79465 ? 84  ILE A N   1 
ATOM   633  C CA  . ILE A 1 90  ? -13.70287 4.29736   34.55159 1.000 19.55338 ? 84  ILE A CA  1 
ATOM   634  C C   . ILE A 1 90  ? -14.82192 3.57489   33.82050 1.000 21.87332 ? 84  ILE A C   1 
ATOM   635  O O   . ILE A 1 90  ? -14.66665 2.41055   33.42311 1.000 24.00537 ? 84  ILE A O   1 
ATOM   636  C CB  . ILE A 1 90  ? -12.46034 4.39146   33.65687 1.000 20.33115 ? 84  ILE A CB  1 
ATOM   637  C CG1 . ILE A 1 90  ? -11.38936 5.27598   34.32097 1.000 21.20432 ? 84  ILE A CG1 1 
ATOM   638  C CG2 . ILE A 1 90  ? -12.85983 4.91977   32.27721 1.000 21.39568 ? 84  ILE A CG2 1 
ATOM   639  C CD1 . ILE A 1 90  ? -10.00964 5.23854   33.61361 1.000 22.18185 ? 84  ILE A CD1 1 
ATOM   640  N N   . ASN A 1 91  ? -15.97080 4.24154   33.66239 1.000 20.98060 ? 85  ASN A N   1 
ATOM   641  C CA  . ASN A 1 91  ? -17.10113 3.66090   32.95010 1.000 22.08857 ? 85  ASN A CA  1 
ATOM   642  C C   . ASN A 1 91  ? -17.05262 3.88579   31.45326 1.000 23.14787 ? 85  ASN A C   1 
ATOM   643  O O   . ASN A 1 91  ? -17.58784 3.06692   30.68271 1.000 25.40674 ? 85  ASN A O   1 
ATOM   644  C CB  . ASN A 1 91  ? -18.40657 4.25991   33.46002 1.000 25.74887 ? 85  ASN A CB  1 
ATOM   645  C CG  . ASN A 1 91  ? -18.62203 4.05203   34.96284 1.000 29.80436 ? 85  ASN A CG  1 
ATOM   646  O OD1 . ASN A 1 91  ? -17.95994 3.23764   35.60177 1.000 32.48607 ? 85  ASN A OD1 1 
ATOM   647  N ND2 . ASN A 1 91  ? -19.59327 4.77344   35.51298 1.000 29.70491 ? 85  ASN A ND2 1 
ATOM   648  N N   . ASP A 1 92  ? -16.43746 4.98425   31.03118 1.000 22.66224 ? 86  ASP A N   1 
ATOM   649  C CA  . ASP A 1 92  ? -16.44140 5.36758   29.62483 1.000 22.26592 ? 86  ASP A CA  1 
ATOM   650  C C   . ASP A 1 92  ? -15.34913 6.40970   29.48415 1.000 21.26268 ? 86  ASP A C   1 
ATOM   651  O O   . ASP A 1 92  ? -15.01082 7.07462   30.45377 1.000 19.75133 ? 86  ASP A O   1 
ATOM   652  C CB  . ASP A 1 92  ? -17.81718 5.93000   29.19288 1.000 21.72895 ? 86  ASP A CB  1 
ATOM   653  C CG  . ASP A 1 92  ? -17.97555 6.05367   27.68045 1.000 24.38574 ? 86  ASP A CG  1 
ATOM   654  O OD1 . ASP A 1 92  ? -17.11802 5.59091   26.90442 1.000 24.70151 ? 86  ASP A OD1 1 
ATOM   655  O OD2 . ASP A 1 92  ? -18.99350 6.66477   27.27365 1.000 25.75408 ? 86  ASP A OD2 1 
ATOM   656  N N   . ILE A 1 93  ? -14.76590 6.50971   28.29393 1.000 20.56331 ? 87  ILE A N   1 
ATOM   657  C CA  . ILE A 1 93  ? -13.83096 7.58144   27.98383 1.000 19.83509 ? 87  ILE A CA  1 
ATOM   658  C C   . ILE A 1 93  ? -14.23906 8.15707   26.65595 1.000 20.84263 ? 87  ILE A C   1 
ATOM   659  O O   . ILE A 1 93  ? -14.42608 7.40320   25.69931 1.000 22.45321 ? 87  ILE A O   1 
ATOM   660  C CB  . ILE A 1 93  ? -12.36547 7.10319   27.93167 1.000 19.71342 ? 87  ILE A CB  1 
ATOM   661  C CG1 . ILE A 1 93  ? -11.98295 6.45081   29.25236 1.000 19.84986 ? 87  ILE A CG1 1 
ATOM   662  C CG2 . ILE A 1 93  ? -11.44854 8.28850   27.61893 1.000 20.24989 ? 87  ILE A CG2 1 
ATOM   663  C CD1 . ILE A 1 93  ? -10.52960 5.89715   29.21884 1.000 22.25856 ? 87  ILE A CD1 1 
ATOM   664  N N   . ILE A 1 94  ? -14.36913 9.48404   26.59910 1.000 21.01388 ? 88  ILE A N   1 
ATOM   665  C CA  . ILE A 1 94  ? -14.81549 10.20548  25.41258 1.000 22.06501 ? 88  ILE A CA  1 
ATOM   666  C C   . ILE A 1 94  ? -13.64872 10.99362  24.85315 1.000 21.17800 ? 88  ILE A C   1 
ATOM   667  O O   . ILE A 1 94  ? -12.98471 11.73527  25.59295 1.000 22.13715 ? 88  ILE A O   1 
ATOM   668  C CB  . ILE A 1 94  ? -15.97220 11.15600  25.74787 1.000 23.88697 ? 88  ILE A CB  1 
ATOM   669  C CG1 . ILE A 1 94  ? -17.13787 10.40275  26.41773 1.000 26.71020 ? 88  ILE A CG1 1 
ATOM   670  C CG2 . ILE A 1 94  ? -16.37334 11.96741  24.52934 1.000 24.67819 ? 88  ILE A CG2 1 
ATOM   671  C CD1 . ILE A 1 94  ? -17.96640 11.32802  27.29764 1.000 27.85224 ? 88  ILE A CD1 1 
ATOM   672  N N   . ARG A 1 95  ? -13.41074 10.85453  23.55125 1.000 19.92724 ? 89  ARG A N   1 
ATOM   673  C CA  . ARG A 1 95  ? -12.47645 11.71800  22.83703 1.000 20.24231 ? 89  ARG A CA  1 
ATOM   674  C C   . ARG A 1 95  ? -12.75782 11.63736  21.33541 1.000 20.91795 ? 89  ARG A C   1 
ATOM   675  O O   . ARG A 1 95  ? -13.54262 10.80220  20.85696 1.000 21.81080 ? 89  ARG A O   1 
ATOM   676  C CB  . ARG A 1 95  ? -11.00591 11.35462  23.15177 1.000 21.89294 ? 89  ARG A CB  1 
ATOM   677  C CG  . ARG A 1 95  ? -10.67683 9.86229   23.10636 1.000 24.22127 ? 89  ARG A CG  1 
ATOM   678  C CD  . ARG A 1 95  ? -10.11550 9.47163   21.84889 1.000 23.89893 ? 89  ARG A CD  1 
ATOM   679  N NE  . ARG A 1 95  ? -9.56387  8.12190   21.80236 1.000 21.91951 ? 89  ARG A NE  1 
ATOM   680  C CZ  . ARG A 1 95  ? -9.66271  7.35912   20.71353 1.000 23.53135 ? 89  ARG A CZ  1 
ATOM   681  N NH1 . ARG A 1 95  ? -10.37212 7.75790   19.65563 1.000 22.52998 ? 89  ARG A NH1 1 
ATOM   682  N NH2 . ARG A 1 95  ? -9.04257  6.17617   20.68435 1.000 23.93986 ? 89  ARG A NH2 1 
ATOM   683  N N   . ALA A 1 96  ? -12.11327 12.53170  20.60043 1.000 20.57840 ? 90  ALA A N   1 
ATOM   684  C CA  . ALA A 1 96  ? -12.27677 12.58687  19.15358 1.000 20.68093 ? 90  ALA A CA  1 
ATOM   685  C C   . ALA A 1 96  ? -11.81368 11.28731  18.47093 1.000 21.21662 ? 90  ALA A C   1 
ATOM   686  O O   . ALA A 1 96  ? -11.04347 10.50621  19.03823 1.000 22.02958 ? 90  ALA A O   1 
ATOM   687  C CB  . ALA A 1 96  ? -11.49221 13.76698  18.62368 1.000 21.58024 ? 90  ALA A CB  1 
ATOM   688  N N   . PRO A 1 97  ? -12.26741 11.02239  17.24322 1.000 20.08537 ? 91  PRO A N   1 
ATOM   689  C CA  . PRO A 1 97  ? -11.90527 9.73789   16.60920 1.000 22.52479 ? 91  PRO A CA  1 
ATOM   690  C C   . PRO A 1 97  ? -10.49571 9.63952   16.09231 1.000 22.08140 ? 91  PRO A C   1 
ATOM   691  O O   . PRO A 1 97  ? -10.08827 8.53885   15.71524 1.000 22.95430 ? 91  PRO A O   1 
ATOM   692  C CB  . PRO A 1 97  ? -12.88935 9.61916   15.45387 1.000 22.23944 ? 91  PRO A CB  1 
ATOM   693  C CG  . PRO A 1 97  ? -13.23499 11.02520  15.10459 1.000 20.79762 ? 91  PRO A CG  1 
ATOM   694  C CD  . PRO A 1 97  ? -13.28468 11.75643  16.46342 1.000 20.34685 ? 91  PRO A CD  1 
ATOM   695  N N   . THR A 1 98  ? -9.76025  10.74405  16.00577 1.000 21.76514 ? 92  THR A N   1 
ATOM   696  C CA  . THR A 1 98  ? -8.41568  10.74605  15.44673 1.000 22.14737 ? 92  THR A CA  1 
ATOM   697  C C   . THR A 1 98  ? -7.51341  11.54349  16.36614 1.000 23.43223 ? 92  THR A C   1 
ATOM   698  O O   . THR A 1 98  ? -7.97782  12.41626  17.11166 1.000 24.09418 ? 92  THR A O   1 
ATOM   699  C CB  . THR A 1 98  ? -8.38113  11.36698  14.03978 1.000 22.68820 ? 92  THR A CB  1 
ATOM   700  O OG1 . THR A 1 98  ? -8.73688  12.75474  14.11351 1.000 22.34320 ? 92  THR A OG1 1 
ATOM   701  C CG2 . THR A 1 98  ? -9.32919  10.65110  13.11408 1.000 24.77765 ? 92  THR A CG2 1 
ATOM   702  N N   . ILE A 1 99  ? -6.21736  11.19971  16.35072 1.000 25.47308 ? 93  ILE A N   1 
ATOM   703  C CA  . ILE A 1 99  ? -5.24601  11.91957  17.17519 1.000 28.39527 ? 93  ILE A CA  1 
ATOM   704  C C   . ILE A 1 99  ? -5.21941  13.38692  16.80227 1.000 30.09295 ? 93  ILE A C   1 
ATOM   705  O O   . ILE A 1 99  ? -5.14276  14.25980  17.68096 1.000 30.66147 ? 93  ILE A O   1 
ATOM   706  C CB  A ILE A 1 99  ? -3.86180  11.24193  17.08383 0.320 29.63137 ? 93  ILE A CB  1 
ATOM   707  C CB  B ILE A 1 99  ? -3.85107  11.29702  17.00664 0.680 28.36935 ? 93  ILE A CB  1 
ATOM   708  C CG1 A ILE A 1 99  ? -3.04456  11.50140  18.34860 0.320 30.24867 ? 93  ILE A CG1 1 
ATOM   709  C CG1 B ILE A 1 99  ? -3.81553  9.90964   17.62324 0.680 29.71090 ? 93  ILE A CG1 1 
ATOM   710  C CG2 A ILE A 1 99  ? -3.09566  11.62913  15.82377 0.320 30.51713 ? 93  ILE A CG2 1 
ATOM   711  C CG2 B ILE A 1 99  ? -2.74517  12.23722  17.56623 0.680 27.55366 ? 93  ILE A CG2 1 
ATOM   712  C CD1 A ILE A 1 99  ? -1.79262  10.67410  18.40113 0.320 29.89805 ? 93  ILE A CD1 1 
ATOM   713  C CD1 B ILE A 1 99  ? -2.41288  9.32755   17.69596 0.680 32.40478 ? 93  ILE A CD1 1 
ATOM   714  N N   . GLU A 1 100 ? -5.30876  13.68295  15.48561 1.000 29.52846 ? 94  GLU A N   1 
ATOM   715  C CA  . GLU A 1 100 ? -5.27550  15.05552  15.01928 1.000 30.06722 ? 94  GLU A CA  1 
ATOM   716  C C   . GLU A 1 100 ? -6.38764  15.87826  15.63373 1.000 29.78896 ? 94  GLU A C   1 
ATOM   717  O O   . GLU A 1 100 ? -6.18775  17.05351  15.96739 1.000 32.26044 ? 94  GLU A O   1 
ATOM   718  C CB  . GLU A 1 100 ? -5.38248  15.09924  13.48635 1.000 30.21747 ? 94  GLU A CB  1 
ATOM   719  C CG  . GLU A 1 100 ? -4.13808  14.59711  12.83522 0.479 30.69404 ? 94  GLU A CG  1 
ATOM   720  C CD  . GLU A 1 100 ? -4.18895  13.14855  12.42370 0.650 31.22479 ? 94  GLU A CD  1 
ATOM   721  O OE1 . GLU A 1 100 ? -4.90756  12.32617  13.06125 0.941 31.86244 ? 94  GLU A OE1 1 
ATOM   722  O OE2 . GLU A 1 100 ? -3.42263  12.82869  11.49925 0.522 31.46264 ? 94  GLU A OE2 1 
ATOM   723  N N   . GLN A 1 101 ? -7.57317  15.29072  15.75967 1.000 26.20268 ? 95  GLN A N   1 
ATOM   724  C CA  . GLN A 1 101 ? -8.73269  15.99743  16.26260 1.000 23.32826 ? 95  GLN A CA  1 
ATOM   725  C C   . GLN A 1 101 ? -8.84846  15.93379  17.77224 1.000 24.95789 ? 95  GLN A C   1 
ATOM   726  O O   . GLN A 1 101 ? -9.70623  16.62898  18.33888 1.000 25.13428 ? 95  GLN A O   1 
ATOM   727  C CB  . GLN A 1 101 ? -10.00074 15.41359  15.61811 1.000 21.95424 ? 95  GLN A CB  1 
ATOM   728  C CG  . GLN A 1 101 ? -10.07887 15.72449  14.11746 1.000 21.23349 ? 95  GLN A CG  1 
ATOM   729  C CD  . GLN A 1 101 ? -11.18219 14.97514  13.41843 1.000 21.97241 ? 95  GLN A CD  1 
ATOM   730  O OE1 . GLN A 1 101 ? -12.10319 15.59152  12.82935 1.000 25.13733 ? 95  GLN A OE1 1 
ATOM   731  N NE2 . GLN A 1 101 ? -11.08675 13.66004  13.41424 1.000 22.06175 ? 95  GLN A NE2 1 
ATOM   732  N N   . MET A 1 102 ? -8.01553  15.14158  18.44087 1.000 23.91623 ? 96  MET A N   1 
ATOM   733  C CA  . MET A 1 102 ? -8.17556  14.95172  19.88481 1.000 25.01777 ? 96  MET A CA  1 
ATOM   734  C C   . MET A 1 102 ? -7.40766  16.01793  20.64616 1.000 27.56219 ? 96  MET A C   1 
ATOM   735  O O   . MET A 1 102 ? -6.16981  16.05002  20.63194 1.000 30.16586 ? 96  MET A O   1 
ATOM   736  C CB  . MET A 1 102 ? -7.83383  13.51789  20.27149 1.000 24.92317 ? 96  MET A CB  1 
ATOM   737  C CG  . MET A 1 102 ? -8.02861  13.20758  21.72849 1.000 25.74448 ? 96  MET A CG  1 
ATOM   738  S SD  . MET A 1 102 ? -7.19364  11.73907  22.36680 1.000 26.20659 ? 96  MET A SD  1 
ATOM   739  C CE  . MET A 1 102 ? -5.46559  11.93547  22.00918 1.000 24.85861 ? 96  MET A CE  1 
ATOM   740  N N   . LYS A 1 103 ? -8.16056  16.89357  21.32398 1.000 30.12981 ? 97  LYS A N   1 
ATOM   741  C CA  . LYS A 1 103 ? -7.59787  17.97977  22.12885 1.000 32.24525 ? 97  LYS A CA  1 
ATOM   742  C C   . LYS A 1 103 ? -7.85624  17.81065  23.60797 1.000 31.82093 ? 97  LYS A C   1 
ATOM   743  O O   . LYS A 1 103 ? -7.15843  18.42555  24.41870 1.000 34.02493 ? 97  LYS A O   1 
ATOM   744  C CB  . LYS A 1 103 ? -8.21128  19.32849  21.73171 0.975 33.12087 ? 97  LYS A CB  1 
ATOM   745  C CG  . LYS A 1 103 ? -8.35284  19.57140  20.22989 0.690 35.07418 ? 97  LYS A CG  1 
ATOM   746  C CD  . LYS A 1 103 ? -7.07819  20.03973  19.60217 0.594 37.12500 ? 97  LYS A CD  1 
ATOM   747  C CE  . LYS A 1 103 ? -6.95297  19.47911  18.18786 0.748 38.73145 ? 97  LYS A CE  1 
ATOM   748  N NZ  . LYS A 1 103 ? -6.13464  20.38465  17.37846 0.555 38.93736 ? 97  LYS A NZ  1 
ATOM   749  N N   . ASP A 1 104 ? -8.91155  17.09137  23.96924 1.000 30.46081 ? 98  ASP A N   1 
ATOM   750  C CA  . ASP A 1 104 ? -9.26947  16.82147  25.36149 1.000 29.95995 ? 98  ASP A CA  1 
ATOM   751  C C   . ASP A 1 104 ? -9.68684  15.36636  25.47733 1.000 26.27116 ? 98  ASP A C   1 
ATOM   752  O O   . ASP A 1 104 ? -9.96388  14.71287  24.49137 1.000 26.97808 ? 98  ASP A O   1 
ATOM   753  C CB  . ASP A 1 104 ? -10.42267 17.71230  25.84987 1.000 31.83928 ? 98  ASP A CB  1 
ATOM   754  C CG  . ASP A 1 104 ? -10.19344 19.18495  25.53275 0.844 34.27656 ? 98  ASP A CG  1 
ATOM   755  O OD1 . ASP A 1 104 ? -9.27166  19.79446  26.10911 0.769 36.26987 ? 98  ASP A OD1 1 
ATOM   756  O OD2 . ASP A 1 104 ? -10.92670 19.72099  24.69600 0.731 34.83398 ? 98  ASP A OD2 1 
ATOM   757  N N   . VAL A 1 105 ? -9.71950  14.85048  26.69121 1.000 26.16565 ? 99  VAL A N   1 
ATOM   758  C CA  . VAL A 1 105 ? -10.24286 13.51734  26.96553 1.000 25.02226 ? 99  VAL A CA  1 
ATOM   759  C C   . VAL A 1 105 ? -11.19599 13.67338  28.13117 1.000 25.41273 ? 99  VAL A C   1 
ATOM   760  O O   . VAL A 1 105 ? -10.91400 14.46127  29.04055 1.000 26.43328 ? 99  VAL A O   1 
ATOM   761  C CB  . VAL A 1 105 ? -9.10782  12.53342  27.32566 1.000 27.49232 ? 99  VAL A CB  1 
ATOM   762  C CG1 . VAL A 1 105 ? -9.67217  11.22130  27.73436 1.000 29.19934 ? 99  VAL A CG1 1 
ATOM   763  C CG2 . VAL A 1 105 ? -8.16513  12.37828  26.16939 1.000 29.52828 ? 99  VAL A CG2 1 
ATOM   764  N N   . TYR A 1 106 ? -12.32636 12.96240  28.09841 1.000 22.78373 ? 100 TYR A N   1 
ATOM   765  C CA  . TYR A 1 106 ? -13.28970 13.00468  29.18955 1.000 22.62946 ? 100 TYR A CA  1 
ATOM   766  C C   . TYR A 1 106 ? -13.41452 11.61979  29.79219 1.000 22.46773 ? 100 TYR A C   1 
ATOM   767  O O   . TYR A 1 106 ? -13.63929 10.65079  29.06379 1.000 23.11190 ? 100 TYR A O   1 
ATOM   768  C CB  . TYR A 1 106 ? -14.67578 13.46695  28.71220 1.000 22.17505 ? 100 TYR A CB  1 
ATOM   769  C CG  . TYR A 1 106 ? -14.64890 14.82464  28.05451 1.000 24.57798 ? 100 TYR A CG  1 
ATOM   770  C CD1 . TYR A 1 106 ? -14.25288 14.95978  26.71021 1.000 25.47728 ? 100 TYR A CD1 1 
ATOM   771  C CD2 . TYR A 1 106 ? -15.04559 15.98073  28.75424 1.000 26.59571 ? 100 TYR A CD2 1 
ATOM   772  C CE1 . TYR A 1 106 ? -14.22838 16.17694  26.11587 1.000 28.68877 ? 100 TYR A CE1 1 
ATOM   773  C CE2 . TYR A 1 106 ? -15.03836 17.23136  28.13128 1.000 28.52689 ? 100 TYR A CE2 1 
ATOM   774  C CZ  . TYR A 1 106 ? -14.61185 17.31810  26.81281 1.000 30.62108 ? 100 TYR A CZ  1 
ATOM   775  O OH  . TYR A 1 106 ? -14.58560 18.52121  26.14700 1.000 32.77502 ? 100 TYR A OH  1 
ATOM   776  N N   . ILE A 1 107 ? -13.33057 11.54320  31.11793 1.000 20.62907 ? 101 ILE A N   1 
ATOM   777  C CA  . ILE A 1 107 ? -13.45640 10.29964  31.87628 1.000 21.02287 ? 101 ILE A CA  1 
ATOM   778  C C   . ILE A 1 107 ? -14.80391 10.28900  32.55283 1.000 19.38295 ? 101 ILE A C   1 
ATOM   779  O O   . ILE A 1 107 ? -15.09227 11.18539  33.35971 1.000 21.29699 ? 101 ILE A O   1 
ATOM   780  C CB  . ILE A 1 107 ? -12.34745 10.15568  32.92255 1.000 24.82665 ? 101 ILE A CB  1 
ATOM   781  C CG1 . ILE A 1 107 ? -11.02604 10.41154  32.22193 1.000 28.31687 ? 101 ILE A CG1 1 
ATOM   782  C CG2 . ILE A 1 107 ? -12.38685 8.78207   33.54906 1.000 25.72066 ? 101 ILE A CG2 1 
ATOM   783  C CD1 . ILE A 1 107 ? -10.76310 9.37314   31.25970 1.000 29.21790 ? 101 ILE A CD1 1 
ATOM   784  N N   . VAL A 1 108 ? -15.60261 9.24374   32.30161 1.000 19.35679 ? 102 VAL A N   1 
ATOM   785  C CA  . VAL A 1 108 ? -16.93914 9.12227   32.89333 1.000 18.86318 ? 102 VAL A CA  1 
ATOM   786  C C   . VAL A 1 108 ? -16.85401 8.13025   34.03976 1.000 19.02489 ? 102 VAL A C   1 
ATOM   787  O O   . VAL A 1 108 ? -16.34507 7.02618   33.85510 1.000 20.23452 ? 102 VAL A O   1 
ATOM   788  C CB  . VAL A 1 108 ? -17.95611 8.63880   31.84341 1.000 19.62095 ? 102 VAL A CB  1 
ATOM   789  C CG1 . VAL A 1 108 ? -19.36173 8.61852   32.45716 1.000 20.32156 ? 102 VAL A CG1 1 
ATOM   790  C CG2 . VAL A 1 108 ? -17.91644 9.52889   30.61496 1.000 20.71442 ? 102 VAL A CG2 1 
ATOM   791  N N   . GLN A 1 109 ? -17.38987 8.49751   35.21277 1.000 18.73916 ? 103 GLN A N   1 
ATOM   792  C CA  . GLN A 1 109 ? -17.28176 7.69678   36.42832 1.000 19.00092 ? 103 GLN A CA  1 
ATOM   793  C C   . GLN A 1 109 ? -18.60707 7.77606   37.16692 1.000 21.49661 ? 103 GLN A C   1 
ATOM   794  O O   . GLN A 1 109 ? -19.47245 8.61465   36.84002 1.000 23.32468 ? 103 GLN A O   1 
ATOM   795  C CB  . GLN A 1 109 ? -16.11973 8.18316   37.32182 1.000 19.26897 ? 103 GLN A CB  1 
ATOM   796  C CG  . GLN A 1 109 ? -14.78214 8.12420   36.54061 1.000 21.26585 ? 103 GLN A CG  1 
ATOM   797  C CD  . GLN A 1 109 ? -13.57986 8.46072   37.35271 1.000 23.91861 ? 103 GLN A CD  1 
ATOM   798  O OE1 . GLN A 1 109 ? -13.20333 9.61979   37.42957 1.000 25.86253 ? 103 GLN A OE1 1 
ATOM   799  N NE2 . GLN A 1 109 ? -12.92711 7.42518   37.95419 1.000 22.52574 ? 103 GLN A NE2 1 
ATOM   800  N N   . ASP A 1 110 ? -18.77113 6.90045   38.16599 1.000 20.82278 ? 104 ASP A N   1 
ATOM   801  C CA  . ASP A 1 110 ? -19.98017 6.90984   38.98278 1.000 22.48250 ? 104 ASP A CA  1 
ATOM   802  C C   . ASP A 1 110 ? -20.19324 8.28816   39.60893 1.000 22.57307 ? 104 ASP A C   1 
ATOM   803  O O   . ASP A 1 110 ? -19.23987 8.95627   40.02095 1.000 21.49157 ? 104 ASP A O   1 
ATOM   804  C CB  . ASP A 1 110 ? -19.89263 5.85151   40.09032 1.000 24.19261 ? 104 ASP A CB  1 
ATOM   805  C CG  . ASP A 1 110 ? -19.87887 4.42946   39.54740 1.000 26.09417 ? 104 ASP A CG  1 
ATOM   806  O OD1 . ASP A 1 110 ? -20.33753 4.20862   38.40331 1.000 28.04244 ? 104 ASP A OD1 1 
ATOM   807  O OD2 . ASP A 1 110 ? -19.41086 3.52712   40.27544 0.695 25.89752 ? 104 ASP A OD2 1 
ATOM   808  N N   . LEU A 1 111 ? -21.44515 8.72391   39.67713 1.000 23.41171 ? 105 LEU A N   1 
ATOM   809  C CA  . LEU A 1 111 ? -21.75308 9.99302   40.33325 1.000 24.68794 ? 105 LEU A CA  1 
ATOM   810  C C   . LEU A 1 111 ? -21.92355 9.72166   41.82877 1.000 22.72062 ? 105 LEU A C   1 
ATOM   811  O O   . LEU A 1 111 ? -22.83592 9.00835   42.24123 1.000 24.75857 ? 105 LEU A O   1 
ATOM   812  C CB  . LEU A 1 111 ? -23.01349 10.63585  39.76567 1.000 25.65551 ? 105 LEU A CB  1 
ATOM   813  C CG  . LEU A 1 111 ? -23.39108 11.97242  40.43133 1.000 25.47351 ? 105 LEU A CG  1 
ATOM   814  C CD1 . LEU A 1 111 ? -22.31442 13.01975  40.23107 1.000 26.93824 ? 105 LEU A CD1 1 
ATOM   815  C CD2 . LEU A 1 111 ? -24.73378 12.50035  39.93372 1.000 26.11916 ? 105 LEU A CD2 1 
ATOM   816  N N   . MET A 1 112 ? -21.00618 10.23029  42.62634 1.000 21.51697 ? 106 MET A N   1 
ATOM   817  C CA  . MET A 1 112 ? -21.04328 10.12867  44.07081 1.000 19.99873 ? 106 MET A CA  1 
ATOM   818  C C   . MET A 1 112 ? -21.77470 11.33729  44.64616 1.000 22.79814 ? 106 MET A C   1 
ATOM   819  O O   . MET A 1 112 ? -22.05768 12.31071  43.94262 1.000 25.36113 ? 106 MET A O   1 
ATOM   820  C CB  . MET A 1 112 ? -19.60708 10.04341  44.53585 1.000 20.57917 ? 106 MET A CB  1 
ATOM   821  C CG  . MET A 1 112 ? -18.88322 8.79540   44.36122 1.000 23.11873 ? 106 MET A CG  1 
ATOM   822  S SD  . MET A 1 112 ? -19.63905 7.16137   44.43584 1.000 23.51840 ? 106 MET A SD  1 
ATOM   823  C CE  . MET A 1 112 ? -18.81456 6.80514   45.97674 1.000 23.75014 ? 106 MET A CE  1 
ATOM   824  N N   . GLU A 1 113 ? -22.07752 11.28616  45.93586 1.000 21.84915 ? 107 GLU A N   1 
ATOM   825  C CA  . GLU A 1 113 ? -22.82325 12.39389  46.53683 1.000 22.38386 ? 107 GLU A CA  1 
ATOM   826  C C   . GLU A 1 113 ? -21.91097 13.49365  47.06611 1.000 22.02533 ? 107 GLU A C   1 
ATOM   827  O O   . GLU A 1 113 ? -22.23923 14.68965  46.95179 1.000 22.54393 ? 107 GLU A O   1 
ATOM   828  C CB  . GLU A 1 113 ? -23.69888 11.88100  47.68094 1.000 22.25380 ? 107 GLU A CB  1 
ATOM   829  C CG  . GLU A 1 113 ? -24.44751 12.98496  48.42159 0.741 24.43903 ? 107 GLU A CG  1 
ATOM   830  C CD  . GLU A 1 113 ? -25.46654 12.44085  49.41219 0.498 25.37335 ? 107 GLU A CD  1 
ATOM   831  O OE1 . GLU A 1 113 ? -26.53664 11.95120  48.97772 0.479 26.11463 ? 107 GLU A OE1 1 
ATOM   832  O OE2 . GLU A 1 113 ? -25.18489 12.46360  50.62431 0.483 26.29279 ? 107 GLU A OE2 1 
ATOM   833  N N   . THR A 1 114 ? -20.77066 13.12806  47.65522 1.000 21.37017 ? 108 THR A N   1 
ATOM   834  C CA  . THR A 1 114 ? -19.91048 14.12032  48.28284 1.000 19.98929 ? 108 THR A CA  1 
ATOM   835  C C   . THR A 1 114 ? -18.50355 13.51897  48.36613 1.000 20.52431 ? 108 THR A C   1 
ATOM   836  O O   . THR A 1 114 ? -18.22729 12.46342  47.79975 1.000 19.73809 ? 108 THR A O   1 
ATOM   837  C CB  . THR A 1 114 ? -20.49793 14.52345  49.65149 1.000 23.82389 ? 108 THR A CB  1 
ATOM   838  O OG1 . THR A 1 114 ? -19.78035 15.63320  50.18765 1.000 26.96025 ? 108 THR A OG1 1 
ATOM   839  C CG2 . THR A 1 114 ? -20.45742 13.37070  50.60003 1.000 23.55199 ? 108 THR A CG2 1 
ATOM   840  N N   . ASP A 1 115 ? -17.61173 14.18230  49.07027 1.000 22.38318 ? 109 ASP A N   1 
ATOM   841  C CA  . ASP A 1 115 ? -16.28579 13.62669  49.35904 1.000 22.43120 ? 109 ASP A CA  1 
ATOM   842  C C   . ASP A 1 115 ? -15.96589 13.97141  50.80032 1.000 21.82095 ? 109 ASP A C   1 
ATOM   843  O O   . ASP A 1 115 ? -16.67375 14.75749  51.42905 1.000 21.55770 ? 109 ASP A O   1 
ATOM   844  C CB  . ASP A 1 115 ? -15.20473 14.16325  48.41296 1.000 24.69631 ? 109 ASP A CB  1 
ATOM   845  C CG  . ASP A 1 115 ? -15.06548 15.66514  48.47708 1.000 26.69971 ? 109 ASP A CG  1 
ATOM   846  O OD1 . ASP A 1 115 ? -14.52203 16.15762  49.46914 1.000 25.80035 ? 109 ASP A OD1 1 
ATOM   847  O OD2 . ASP A 1 115 ? -15.48907 16.35775  47.51351 1.000 30.10120 ? 109 ASP A OD2 1 
ATOM   848  N N   . LEU A 1 116 ? -14.92252 13.35061  51.34452 1.000 20.19211 ? 110 LEU A N   1 
ATOM   849  C CA  . LEU A 1 116 ? -14.70820 13.46180  52.77231 1.000 18.97053 ? 110 LEU A CA  1 
ATOM   850  C C   . LEU A 1 116 ? -14.13574 14.84595  53.12100 1.000 18.66605 ? 110 LEU A C   1 
ATOM   851  O O   . LEU A 1 116 ? -14.34243 15.32340  54.23606 1.000 18.93409 ? 110 LEU A O   1 
ATOM   852  C CB  . LEU A 1 116 ? -13.76176 12.34278  53.21863 1.000 18.50851 ? 110 LEU A CB  1 
ATOM   853  C CG  . LEU A 1 116 ? -13.40757 12.25589  54.70679 1.000 19.12195 ? 110 LEU A CG  1 
ATOM   854  C CD1 . LEU A 1 116 ? -14.73120 11.93315  55.47752 1.000 20.75771 ? 110 LEU A CD1 1 
ATOM   855  C CD2 . LEU A 1 116 ? -12.41179 11.20314  54.97252 1.000 19.53112 ? 110 LEU A CD2 1 
ATOM   856  N N   . TYR A 1 117 ? -13.45893 15.52309  52.17679 1.000 18.48659 ? 111 TYR A N   1 
ATOM   857  C CA  . TYR A 1 117 ? -13.05042 16.91238  52.40880 1.000 20.81791 ? 111 TYR A CA  1 
ATOM   858  C C   . TYR A 1 117 ? -14.27036 17.78353  52.66298 1.000 21.53902 ? 111 TYR A C   1 
ATOM   859  O O   . TYR A 1 117 ? -14.32143 18.53897  53.64572 1.000 22.56731 ? 111 TYR A O   1 
ATOM   860  C CB  . TYR A 1 117 ? -12.23765 17.45922  51.21275 1.000 22.04690 ? 111 TYR A CB  1 
ATOM   861  C CG  . TYR A 1 117 ? -11.83183 18.90001  51.35585 1.000 24.91664 ? 111 TYR A CG  1 
ATOM   862  C CD1 . TYR A 1 117 ? -10.74351 19.25555  52.13397 1.000 27.94941 ? 111 TYR A CD1 1 
ATOM   863  C CD2 . TYR A 1 117 ? -12.57031 19.90409  50.76295 1.000 28.03386 ? 111 TYR A CD2 1 
ATOM   864  C CE1 . TYR A 1 117 ? -10.36185 20.57737  52.28440 1.000 29.31474 ? 111 TYR A CE1 1 
ATOM   865  C CE2 . TYR A 1 117 ? -12.20251 21.23394  50.89696 1.000 30.43259 ? 111 TYR A CE2 1 
ATOM   866  C CZ  . TYR A 1 117 ? -11.10042 21.56738  51.67768 1.000 31.63475 ? 111 TYR A CZ  1 
ATOM   867  O OH  . TYR A 1 117 ? -10.73201 22.88803  51.83872 0.549 33.25928 ? 111 TYR A OH  1 
ATOM   868  N N   . LYS A 1 118 ? -15.27650 17.67987  51.79289 1.000 21.79208 ? 112 LYS A N   1 
ATOM   869  C CA  A LYS A 1 118 ? -16.50636 18.45764  51.97487 0.451 23.87894 ? 112 LYS A CA  1 
ATOM   870  C CA  B LYS A 1 118 ? -16.50322 18.46161  51.97813 0.549 23.65521 ? 112 LYS A CA  1 
ATOM   871  C C   . LYS A 1 118 ? -17.20839 18.08338  53.26751 1.000 24.41356 ? 112 LYS A C   1 
ATOM   872  O O   . LYS A 1 118 ? -17.68910 18.95765  54.00988 1.000 25.18447 ? 112 LYS A O   1 
ATOM   873  C CB  A LYS A 1 118 ? -17.46132 18.23232  50.80666 0.451 26.11587 ? 112 LYS A CB  1 
ATOM   874  C CB  B LYS A 1 118 ? -17.45273 18.24300  50.81121 0.549 25.98737 ? 112 LYS A CB  1 
ATOM   875  C CG  A LYS A 1 118 ? -16.93982 18.66060  49.45873 0.451 28.23653 ? 112 LYS A CG  1 
ATOM   876  C CG  B LYS A 1 118 ? -16.94932 18.71199  49.47516 0.549 28.69862 ? 112 LYS A CG  1 
ATOM   877  C CD  A LYS A 1 118 ? -16.12665 19.91456  49.54837 0.451 29.86806 ? 112 LYS A CD  1 
ATOM   878  C CD  B LYS A 1 118 ? -17.92193 18.24866  48.40623 0.549 30.33286 ? 112 LYS A CD  1 
ATOM   879  C CE  A LYS A 1 118 ? -16.39165 20.81048  48.34780 0.451 29.41031 ? 112 LYS A CE  1 
ATOM   880  C CE  B LYS A 1 118 ? -17.65269 18.90122  47.07882 0.549 32.46707 ? 112 LYS A CE  1 
ATOM   881  N NZ  A LYS A 1 118 ? -15.08849 21.34319  47.87834 0.451 27.51084 ? 112 LYS A NZ  1 
ATOM   882  N NZ  B LYS A 1 118 ? -18.42741 18.17074  46.03689 0.549 33.33650 ? 112 LYS A NZ  1 
ATOM   883  N N   . LEU A 1 119 ? -17.31736 16.78360  53.53309 1.000 23.36498 ? 113 LEU A N   1 
ATOM   884  C CA  . LEU A 1 119 ? -18.02865 16.34517  54.72926 1.000 24.81583 ? 113 LEU A CA  1 
ATOM   885  C C   . LEU A 1 119 ? -17.36190 16.86741  55.98701 1.000 25.01989 ? 113 LEU A C   1 
ATOM   886  O O   . LEU A 1 119 ? -18.04157 17.30009  56.92522 1.000 26.37947 ? 113 LEU A O   1 
ATOM   887  C CB  . LEU A 1 119 ? -18.06803 14.83150  54.79142 1.000 27.30979 ? 113 LEU A CB  1 
ATOM   888  C CG  . LEU A 1 119 ? -19.15584 14.04531  54.14587 1.000 29.33891 ? 113 LEU A CG  1 
ATOM   889  C CD1 . LEU A 1 119 ? -18.80124 12.58099  54.48709 1.000 29.01849 ? 113 LEU A CD1 1 
ATOM   890  C CD2 . LEU A 1 119 ? -20.56412 14.45573  54.59229 1.000 29.13767 ? 113 LEU A CD2 1 
ATOM   891  N N   . LEU A 1 120 ? -16.03044 16.80671  56.04310 1.000 23.15138 ? 114 LEU A N   1 
ATOM   892  C CA  . LEU A 1 120 ? -15.35596 17.19660  57.27127 1.000 23.13141 ? 114 LEU A CA  1 
ATOM   893  C C   . LEU A 1 120 ? -15.46031 18.69398  57.51539 1.000 23.04802 ? 114 LEU A C   1 
ATOM   894  O O   . LEU A 1 120 ? -15.29918 19.13125  58.66446 1.000 25.56797 ? 114 LEU A O   1 
ATOM   895  C CB  . LEU A 1 120 ? -13.89455 16.74358  57.22500 1.000 24.41598 ? 114 LEU A CB  1 
ATOM   896  C CG  . LEU A 1 120 ? -13.73664 15.21512  57.32947 1.000 26.18028 ? 114 LEU A CG  1 
ATOM   897  C CD1 . LEU A 1 120 ? -12.31503 14.78959  57.10794 1.000 25.99980 ? 114 LEU A CD1 1 
ATOM   898  C CD2 . LEU A 1 120 ? -14.29219 14.67996  58.68229 1.000 28.89352 ? 114 LEU A CD2 1 
ATOM   899  N N   . LYS A 1 121 ? -15.71676 19.49121  56.47306 1.000 24.63425 ? 115 LYS A N   1 
ATOM   900  C CA  . LYS A 1 121 ? -15.84854 20.94164  56.66333 1.000 27.89213 ? 115 LYS A CA  1 
ATOM   901  C C   . LYS A 1 121 ? -17.07056 21.29264  57.51223 1.000 28.18531 ? 115 LYS A C   1 
ATOM   902  O O   . LYS A 1 121 ? -17.07725 22.32199  58.18368 1.000 29.95514 ? 115 LYS A O   1 
ATOM   903  C CB  . LYS A 1 121 ? -15.97649 21.68501  55.32621 1.000 31.71006 ? 115 LYS A CB  1 
ATOM   904  C CG  . LYS A 1 121 ? -14.74473 21.92280  54.53274 0.969 34.94000 ? 115 LYS A CG  1 
ATOM   905  C CD  . LYS A 1 121 ? -15.10504 22.55522  53.17654 0.640 37.21527 ? 115 LYS A CD  1 
ATOM   906  C CE  . LYS A 1 121 ? -14.04666 23.54628  52.71515 0.483 38.36845 ? 115 LYS A CE  1 
ATOM   907  N NZ  . LYS A 1 121 ? -14.52877 24.39076  51.56007 0.520 39.34526 ? 115 LYS A NZ  1 
ATOM   908  N N   . THR A 1 122 ? -18.11202 20.47321  57.50053 1.000 27.54230 ? 116 THR A N   1 
ATOM   909  C CA  . THR A 1 122 ? -19.33636 20.85681  58.19784 1.000 27.82811 ? 116 THR A CA  1 
ATOM   910  C C   . THR A 1 122 ? -20.02421 19.74401  58.97492 1.000 28.32416 ? 116 THR A C   1 
ATOM   911  O O   . THR A 1 122 ? -21.05308 20.01739  59.60720 1.000 32.88255 ? 116 THR A O   1 
ATOM   912  C CB  . THR A 1 122 ? -20.37375 21.45121  57.22517 0.790 30.43273 ? 116 THR A CB  1 
ATOM   913  O OG1 . THR A 1 122 ? -20.84802 20.41045  56.37315 0.776 32.18513 ? 116 THR A OG1 1 
ATOM   914  C CG2 . THR A 1 122 ? -19.79572 22.59152  56.39425 0.577 29.78374 ? 116 THR A CG2 1 
ATOM   915  N N   . GLN A 1 123 ? -19.55187 18.50658  58.94193 1.000 23.76446 ? 117 GLN A N   1 
ATOM   916  C CA  . GLN A 1 123 ? -20.27616 17.41506  59.58902 1.000 23.52455 ? 117 GLN A CA  1 
ATOM   917  C C   . GLN A 1 123 ? -19.38240 16.73407  60.62355 1.000 22.46236 ? 117 GLN A C   1 
ATOM   918  O O   . GLN A 1 123 ? -18.24997 16.33992  60.31695 1.000 23.79155 ? 117 GLN A O   1 
ATOM   919  C CB  . GLN A 1 123 ? -20.76072 16.35367  58.57371 1.000 23.75799 ? 117 GLN A CB  1 
ATOM   920  C CG  . GLN A 1 123 ? -21.60175 16.91458  57.42874 1.000 24.67204 ? 117 GLN A CG  1 
ATOM   921  C CD  . GLN A 1 123 ? -22.91666 17.48592  57.87941 1.000 26.15503 ? 117 GLN A CD  1 
ATOM   922  O OE1 . GLN A 1 123 ? -23.52655 16.99472  58.81320 1.000 25.91844 ? 117 GLN A OE1 1 
ATOM   923  N NE2 . GLN A 1 123 ? -23.35862 18.54718  57.22211 1.000 28.82099 ? 117 GLN A NE2 1 
ATOM   924  N N   . HIS A 1 124 ? -19.90135 16.59111  61.83851 1.000 23.47691 ? 118 HIS A N   1 
ATOM   925  C CA  . HIS A 1 124 ? -19.31267 15.70038  62.83682 1.000 24.62599 ? 118 HIS A CA  1 
ATOM   926  C C   . HIS A 1 124 ? -19.58348 14.24864  62.45106 1.000 24.10760 ? 118 HIS A C   1 
ATOM   927  O O   . HIS A 1 124 ? -20.71684 13.88996  62.11526 1.000 25.34623 ? 118 HIS A O   1 
ATOM   928  C CB  . HIS A 1 124 ? -19.92753 16.00044  64.20858 1.000 27.37323 ? 118 HIS A CB  1 
ATOM   929  C CG  . HIS A 1 124 ? -19.40659 15.13675  65.31312 0.441 28.84523 ? 118 HIS A CG  1 
ATOM   930  N ND1 . HIS A 1 124 ? -20.14227 14.10884  65.86595 0.516 29.19788 ? 118 HIS A ND1 1 
ATOM   931  C CD2 . HIS A 1 124 ? -18.22318 15.15163  65.97149 0.649 29.49732 ? 118 HIS A CD2 1 
ATOM   932  C CE1 . HIS A 1 124 ? -19.42707 13.51770  66.80859 0.731 29.97461 ? 118 HIS A CE1 1 
ATOM   933  N NE2 . HIS A 1 124 ? -18.26035 14.13604  66.89645 0.434 29.64295 ? 118 HIS A NE2 1 
ATOM   934  N N   . LEU A 1 125 ? -18.55520 13.40753  62.49268 1.000 23.03527 ? 119 LEU A N   1 
ATOM   935  C CA  . LEU A 1 125 ? -18.71229 11.99471  62.19133 1.000 22.37539 ? 119 LEU A CA  1 
ATOM   936  C C   . LEU A 1 125 ? -18.95023 11.22868  63.47910 1.000 24.74771 ? 119 LEU A C   1 
ATOM   937  O O   . LEU A 1 125 ? -18.20299 11.40720  64.46093 1.000 25.51922 ? 119 LEU A O   1 
ATOM   938  C CB  . LEU A 1 125 ? -17.45801 11.42830  61.50439 1.000 22.97651 ? 119 LEU A CB  1 
ATOM   939  C CG  . LEU A 1 125 ? -17.41712 11.62546  59.99154 1.000 26.68664 ? 119 LEU A CG  1 
ATOM   940  C CD1 . LEU A 1 125 ? -17.59216 13.03989  59.63225 1.000 30.16820 ? 119 LEU A CD1 1 
ATOM   941  C CD2 . LEU A 1 125 ? -16.05882 11.11228  59.41345 1.000 25.89717 ? 119 LEU A CD2 1 
ATOM   942  N N   . SER A 1 126 ? -19.94298 10.32750  63.45681 1.000 23.49705 ? 120 SER A N   1 
ATOM   943  C CA  . SER A 1 126 ? -20.10929 9.41615   64.57623 1.000 25.36270 ? 120 SER A CA  1 
ATOM   944  C C   . SER A 1 126 ? -18.95890 8.41743   64.55337 1.000 24.27791 ? 120 SER A C   1 
ATOM   945  O O   . SER A 1 126 ? -18.33017 8.20895   63.51566 1.000 22.73518 ? 120 SER A O   1 
ATOM   946  C CB  . SER A 1 126 ? -21.45802 8.67528   64.49098 1.000 26.49053 ? 120 SER A CB  1 
ATOM   947  O OG  . SER A 1 126 ? -21.40731 7.61820   63.50891 1.000 27.07867 ? 120 SER A OG  1 
ATOM   948  N N   . ASN A 1 127 ? -18.70329 7.76860   65.69403 1.000 25.04369 ? 121 ASN A N   1 
ATOM   949  C CA  . ASN A 1 127 ? -17.65860 6.75295   65.69826 1.000 22.97783 ? 121 ASN A CA  1 
ATOM   950  C C   . ASN A 1 127 ? -17.97986 5.65267   64.71122 1.000 20.72971 ? 121 ASN A C   1 
ATOM   951  O O   . ASN A 1 127 ? -17.07280 5.10188   64.07745 1.000 21.30219 ? 121 ASN A O   1 
ATOM   952  C CB  . ASN A 1 127 ? -17.45088 6.14034   67.07382 1.000 24.18882 ? 121 ASN A CB  1 
ATOM   953  C CG  . ASN A 1 127 ? -16.37600 5.02700   67.02653 0.793 24.69636 ? 121 ASN A CG  1 
ATOM   954  O OD1 . ASN A 1 127 ? -15.21501 5.28739   66.67637 1.000 25.23544 ? 121 ASN A OD1 1 
ATOM   955  N ND2 . ASN A 1 127 ? -16.76258 3.79940   67.34189 0.757 27.28100 ? 121 ASN A ND2 1 
ATOM   956  N N   . ASP A 1 128 ? -19.27194 5.31456   64.55511 1.000 22.86427 ? 122 ASP A N   1 
ATOM   957  C CA  . ASP A 1 128 ? -19.63828 4.27827   63.59364 1.000 22.65605 ? 122 ASP A CA  1 
ATOM   958  C C   . ASP A 1 128 ? -19.28354 4.70476   62.17405 1.000 22.59298 ? 122 ASP A C   1 
ATOM   959  O O   . ASP A 1 128 ? -18.84389 3.88047   61.36025 1.000 23.03285 ? 122 ASP A O   1 
ATOM   960  C CB  . ASP A 1 128 ? -21.14047 3.95921   63.68383 1.000 24.23584 ? 122 ASP A CB  1 
ATOM   961  C CG  . ASP A 1 128 ? -21.50974 3.19749   64.95649 0.491 26.62233 ? 122 ASP A CG  1 
ATOM   962  O OD1 . ASP A 1 128 ? -20.64949 2.46387   65.48774 0.735 29.61453 ? 122 ASP A OD1 1 
ATOM   963  O OD2 . ASP A 1 128 ? -22.67013 3.33525   65.43043 0.519 26.95249 ? 122 ASP A OD2 1 
ATOM   964  N N   . HIS A 1 129 ? -19.47262 5.98714   61.84754 1.000 21.00639 ? 123 HIS A N   1 
ATOM   965  C CA  . HIS A 1 129 ? -19.07792 6.43159   60.50968 1.000 18.46375 ? 123 HIS A CA  1 
ATOM   966  C C   . HIS A 1 129 ? -17.57245 6.37634   60.33845 1.000 18.15757 ? 123 HIS A C   1 
ATOM   967  O O   . HIS A 1 129 ? -17.07514 5.95585   59.27387 1.000 18.18693 ? 123 HIS A O   1 
ATOM   968  C CB  . HIS A 1 129 ? -19.55607 7.84784   60.24145 1.000 18.99405 ? 123 HIS A CB  1 
ATOM   969  C CG  . HIS A 1 129 ? -21.00583 7.92359   59.91448 1.000 20.86694 ? 123 HIS A CG  1 
ATOM   970  N ND1 . HIS A 1 129 ? -21.98192 8.01693   60.88633 1.000 23.03975 ? 123 HIS A ND1 1 
ATOM   971  C CD2 . HIS A 1 129 ? -21.65187 7.88491   58.72137 1.000 20.84412 ? 123 HIS A CD2 1 
ATOM   972  C CE1 . HIS A 1 129 ? -23.16218 8.09649   60.29589 1.000 23.69705 ? 123 HIS A CE1 1 
ATOM   973  N NE2 . HIS A 1 129 ? -22.98886 7.98937   58.98787 1.000 22.35613 ? 123 HIS A NE2 1 
ATOM   974  N N   . ILE A 1 130 ? -16.83597 6.82728   61.35609 1.000 17.49148 ? 124 ILE A N   1 
ATOM   975  C CA  . ILE A 1 130 ? -15.36511 6.81215   61.28093 1.000 15.71077 ? 124 ILE A CA  1 
ATOM   976  C C   . ILE A 1 130 ? -14.87183 5.39644   61.02201 1.000 16.66313 ? 124 ILE A C   1 
ATOM   977  O O   . ILE A 1 130 ? -14.02346 5.16145   60.15417 1.000 17.97137 ? 124 ILE A O   1 
ATOM   978  C CB  . ILE A 1 130 ? -14.74539 7.39879   62.57092 1.000 16.22369 ? 124 ILE A CB  1 
ATOM   979  C CG1 . ILE A 1 130 ? -15.07640 8.87249   62.66007 1.000 17.34679 ? 124 ILE A CG1 1 
ATOM   980  C CG2 . ILE A 1 130 ? -13.22571 7.26121   62.56881 1.000 17.53639 ? 124 ILE A CG2 1 
ATOM   981  C CD1 . ILE A 1 130 ? -14.68276 9.46100   63.95210 1.000 20.99737 ? 124 ILE A CD1 1 
ATOM   982  N N   . CYS A 1 131 ? -15.39148 4.44275   61.79033 1.000 16.69481 ? 125 CYS A N   1 
ATOM   983  C CA  . CYS A 1 131 ? -15.00181 3.04726   61.64908 1.000 16.28848 ? 125 CYS A CA  1 
ATOM   984  C C   . CYS A 1 131 ? -15.29897 2.53286   60.23015 1.000 17.02700 ? 125 CYS A C   1 
ATOM   985  O O   . CYS A 1 131 ? -14.46337 1.89244   59.59278 1.000 16.55922 ? 125 CYS A O   1 
ATOM   986  C CB  . CYS A 1 131 ? -15.77753 2.24889   62.72833 1.000 18.53542 ? 125 CYS A CB  1 
ATOM   987  S SG  . CYS A 1 131 ? -15.21756 0.56924   62.91319 1.000 22.52083 ? 125 CYS A SG  1 
ATOM   988  N N   . TYR A 1 132 ? -16.51256 2.75887   59.73587 1.000 18.47762 ? 126 TYR A N   1 
ATOM   989  C CA  . TYR A 1 132 ? -16.86704 2.26327   58.40780 1.000 17.78337 ? 126 TYR A CA  1 
ATOM   990  C C   . TYR A 1 132 ? -16.05192 2.95077   57.31186 1.000 17.10756 ? 126 TYR A C   1 
ATOM   991  O O   . TYR A 1 132 ? -15.62223 2.29355   56.34202 1.000 17.53490 ? 126 TYR A O   1 
ATOM   992  C CB  . TYR A 1 132 ? -18.36675 2.48079   58.17952 1.000 20.18466 ? 126 TYR A CB  1 
ATOM   993  C CG  . TYR A 1 132 ? -18.91656 1.89931   56.89130 1.000 21.79491 ? 126 TYR A CG  1 
ATOM   994  C CD1 . TYR A 1 132 ? -18.58938 0.58741   56.49546 1.000 25.47000 ? 126 TYR A CD1 1 
ATOM   995  C CD2 . TYR A 1 132 ? -19.75243 2.65617   56.06042 1.000 22.74584 ? 126 TYR A CD2 1 
ATOM   996  C CE1 . TYR A 1 132 ? -19.08611 0.05136   55.30814 1.000 26.34776 ? 126 TYR A CE1 1 
ATOM   997  C CE2 . TYR A 1 132 ? -20.27174 2.11179   54.87044 1.000 24.78968 ? 126 TYR A CE2 1 
ATOM   998  C CZ  . TYR A 1 132 ? -19.91771 0.82884   54.49972 1.000 27.58171 ? 126 TYR A CZ  1 
ATOM   999  O OH  . TYR A 1 132 ? -20.40734 0.26028   53.33029 1.000 32.28384 ? 126 TYR A OH  1 
ATOM   1000 N N   . PHE A 1 133 ? -15.86095 4.27153   57.40768 1.000 16.31278 ? 127 PHE A N   1 
ATOM   1001 C CA  . PHE A 1 133 ? -15.00665 4.94956   56.42117 1.000 15.95430 ? 127 PHE A CA  1 
ATOM   1002 C C   . PHE A 1 133 ? -13.60517 4.36112   56.43319 1.000 14.40369 ? 127 PHE A C   1 
ATOM   1003 O O   . PHE A 1 133 ? -13.02736 4.07290   55.38199 1.000 14.46948 ? 127 PHE A O   1 
ATOM   1004 C CB  . PHE A 1 133 ? -14.91403 6.45758   56.70160 1.000 15.02660 ? 127 PHE A CB  1 
ATOM   1005 C CG  . PHE A 1 133 ? -16.19053 7.22068   56.43434 1.000 16.87748 ? 127 PHE A CG  1 
ATOM   1006 C CD1 . PHE A 1 133 ? -17.19524 6.67283   55.66524 1.000 19.75003 ? 127 PHE A CD1 1 
ATOM   1007 C CD2 . PHE A 1 133 ? -16.37826 8.48782   56.95010 1.000 20.20803 ? 127 PHE A CD2 1 
ATOM   1008 C CE1 . PHE A 1 133 ? -18.36958 7.37445   55.41156 1.000 22.84127 ? 127 PHE A CE1 1 
ATOM   1009 C CE2 . PHE A 1 133 ? -17.60452 9.19385   56.73490 1.000 21.89123 ? 127 PHE A CE2 1 
ATOM   1010 C CZ  . PHE A 1 133 ? -18.55948 8.65103   55.95167 1.000 22.72272 ? 127 PHE A CZ  1 
ATOM   1011 N N   . LEU A 1 134 ? -13.01817 4.22103   57.62184 1.000 15.22661 ? 128 LEU A N   1 
ATOM   1012 C CA  . LEU A 1 134 ? -11.64141 3.71578   57.70585 1.000 14.35504 ? 128 LEU A CA  1 
ATOM   1013 C C   . LEU A 1 134 ? -11.55453 2.30919   57.16171 1.000 14.51319 ? 128 LEU A C   1 
ATOM   1014 O O   . LEU A 1 134 ? -10.60718 1.97613   56.42689 1.000 14.28600 ? 128 LEU A O   1 
ATOM   1015 C CB  . LEU A 1 134 ? -11.13352 3.75413   59.14055 1.000 14.53401 ? 128 LEU A CB  1 
ATOM   1016 C CG  . LEU A 1 134 ? -9.68050  3.26505   59.30569 1.000 14.69741 ? 128 LEU A CG  1 
ATOM   1017 C CD1 . LEU A 1 134 ? -8.65338  4.18977   58.62360 1.000 16.72209 ? 128 LEU A CD1 1 
ATOM   1018 C CD2 . LEU A 1 134 ? -9.36013  3.15921   60.80187 1.000 16.29113 ? 128 LEU A CD2 1 
ATOM   1019 N N   . TYR A 1 135 ? -12.56198 1.47111   57.48592 1.000 14.11433 ? 129 TYR A N   1 
ATOM   1020 C CA  . TYR A 1 135 ? -12.56767 0.11076   56.95260 1.000 14.36421 ? 129 TYR A CA  1 
ATOM   1021 C C   . TYR A 1 135 ? -12.51072 0.13571   55.42949 1.000 14.56015 ? 129 TYR A C   1 
ATOM   1022 O O   . TYR A 1 135 ? -11.72577 -0.60544  54.80049 1.000 14.54769 ? 129 TYR A O   1 
ATOM   1023 C CB  . TYR A 1 135 ? -13.81382 -0.64348  57.43873 1.000 15.23213 ? 129 TYR A CB  1 
ATOM   1024 C CG  . TYR A 1 135 ? -13.91269 -2.01128  56.77426 1.000 15.48209 ? 129 TYR A CG  1 
ATOM   1025 C CD1 . TYR A 1 135 ? -13.00704 -3.03409  57.13083 1.000 16.67014 ? 129 TYR A CD1 1 
ATOM   1026 C CD2 . TYR A 1 135 ? -14.84442 -2.27369  55.78622 1.000 14.71680 ? 129 TYR A CD2 1 
ATOM   1027 C CE1 . TYR A 1 135 ? -13.02463 -4.28561  56.51219 1.000 15.55215 ? 129 TYR A CE1 1 
ATOM   1028 C CE2 . TYR A 1 135 ? -14.90377 -3.54131  55.17802 1.000 15.75205 ? 129 TYR A CE2 1 
ATOM   1029 C CZ  . TYR A 1 135 ? -13.99072 -4.54090  55.54295 1.000 16.71688 ? 129 TYR A CZ  1 
ATOM   1030 O OH  . TYR A 1 135 ? -14.00663 -5.75821  54.91186 1.000 17.51538 ? 129 TYR A OH  1 
ATOM   1031 N N   . GLN A 1 136 ? -13.35630 0.97182   54.81418 1.000 13.57967 ? 130 GLN A N   1 
ATOM   1032 C CA  . GLN A 1 136 ? -13.42604 0.98319   53.35937 1.000 13.56374 ? 130 GLN A CA  1 
ATOM   1033 C C   . GLN A 1 136 ? -12.15963 1.52997   52.73036 1.000 13.91218 ? 130 GLN A C   1 
ATOM   1034 O O   . GLN A 1 136 ? -11.77209 1.07035   51.64745 1.000 13.67511 ? 130 GLN A O   1 
ATOM   1035 C CB  . GLN A 1 136 ? -14.62645 1.79385   52.89156 1.000 13.84105 ? 130 GLN A CB  1 
ATOM   1036 C CG  . GLN A 1 136 ? -15.94352 1.14168   53.32454 1.000 15.10337 ? 130 GLN A CG  1 
ATOM   1037 C CD  . GLN A 1 136 ? -17.08870 1.99659   52.84781 1.000 15.89536 ? 130 GLN A CD  1 
ATOM   1038 O OE1 . GLN A 1 136 ? -17.57161 1.84830   51.70152 0.788 16.01900 ? 130 GLN A OE1 1 
ATOM   1039 N NE2 . GLN A 1 136 ? -17.49429 2.96269   53.70392 1.000 18.23139 ? 130 GLN A NE2 1 
ATOM   1040 N N   . ILE A 1 137 ? -11.55822 2.56753   53.33279 1.000 12.56688 ? 131 ILE A N   1 
ATOM   1041 C CA  . ILE A 1 137 ? -10.28426 3.07315   52.82676 1.000 12.52330 ? 131 ILE A CA  1 
ATOM   1042 C C   . ILE A 1 137 ? -9.26088  1.94036   52.79881 1.000 13.24220 ? 131 ILE A C   1 
ATOM   1043 O O   . ILE A 1 137 ? -8.56795  1.72989   51.79083 1.000 13.53269 ? 131 ILE A O   1 
ATOM   1044 C CB  . ILE A 1 137 ? -9.76064  4.23775   53.70068 1.000 12.02071 ? 131 ILE A CB  1 
ATOM   1045 C CG1 . ILE A 1 137 ? -10.67968 5.43533   53.64108 1.000 13.43353 ? 131 ILE A CG1 1 
ATOM   1046 C CG2 . ILE A 1 137 ? -8.34326  4.64226   53.25171 1.000 13.42137 ? 131 ILE A CG2 1 
ATOM   1047 C CD1 . ILE A 1 137 ? -10.50212 6.45156   54.77728 1.000 13.36852 ? 131 ILE A CD1 1 
ATOM   1048 N N   . LEU A 1 138 ? -9.14350  1.19586   53.92228 1.000 13.50426 ? 132 LEU A N   1 
ATOM   1049 C CA  . LEU A 1 138 ? -8.10734  0.15543   54.01970 1.000 12.92882 ? 132 LEU A CA  1 
ATOM   1050 C C   . LEU A 1 138 ? -8.44424  -1.03565  53.12733 1.000 13.59716 ? 132 LEU A C   1 
ATOM   1051 O O   . LEU A 1 138 ? -7.53880  -1.69396  52.61745 1.000 13.02180 ? 132 LEU A O   1 
ATOM   1052 C CB  . LEU A 1 138 ? -7.96858  -0.31969  55.47833 1.000 12.64188 ? 132 LEU A CB  1 
ATOM   1053 C CG  . LEU A 1 138 ? -7.41984  0.76471   56.42381 1.000 13.20384 ? 132 LEU A CG  1 
ATOM   1054 C CD1 . LEU A 1 138 ? -7.59067  0.28113   57.87178 1.000 16.05272 ? 132 LEU A CD1 1 
ATOM   1055 C CD2 . LEU A 1 138 ? -5.92799  0.98291   56.07024 1.000 15.69785 ? 132 LEU A CD2 1 
ATOM   1056 N N   . ARG A 1 139 ? -9.73359  -1.32707  52.93385 1.000 12.92768 ? 133 ARG A N   1 
ATOM   1057 C CA  . ARG A 1 139 ? -10.13158 -2.40904  52.03566 1.000 12.93255 ? 133 ARG A CA  1 
ATOM   1058 C C   . ARG A 1 139 ? -9.70453  -2.08834  50.60576 1.000 13.44161 ? 133 ARG A C   1 
ATOM   1059 O O   . ARG A 1 139 ? -9.14229  -2.93910  49.90507 1.000 14.73088 ? 133 ARG A O   1 
ATOM   1060 C CB  . ARG A 1 139 ? -11.64593 -2.62997  52.12547 1.000 13.62996 ? 133 ARG A CB  1 
ATOM   1061 C CG  . ARG A 1 139 ? -12.15725 -3.78958  51.33870 1.000 12.45471 ? 133 ARG A CG  1 
ATOM   1062 C CD  . ARG A 1 139 ? -13.64367 -4.03560  51.65775 1.000 14.49655 ? 133 ARG A CD  1 
ATOM   1063 N NE  . ARG A 1 139 ? -14.21490 -5.14436  50.89945 1.000 17.38793 ? 133 ARG A NE  1 
ATOM   1064 C CZ  . ARG A 1 139 ? -15.11094 -5.01679  49.92841 1.000 19.09282 ? 133 ARG A CZ  1 
ATOM   1065 N NH1 . ARG A 1 139 ? -15.44081 -3.81535  49.44111 1.000 21.39963 ? 133 ARG A NH1 1 
ATOM   1066 N NH2 . ARG A 1 139 ? -15.66896 -6.11803  49.40911 1.000 19.19883 ? 133 ARG A NH2 1 
ATOM   1067 N N   . GLY A 1 140 ? -9.96698  -0.86129  50.15636 1.000 12.64817 ? 134 GLY A N   1 
ATOM   1068 C CA  . GLY A 1 140 ? -9.50622  -0.44560  48.83033 1.000 12.67274 ? 134 GLY A CA  1 
ATOM   1069 C C   . GLY A 1 140 ? -7.98914  -0.43073  48.75988 1.000 12.80309 ? 134 GLY A C   1 
ATOM   1070 O O   . GLY A 1 140 ? -7.39066  -0.89341  47.78028 1.000 13.33931 ? 134 GLY A O   1 
ATOM   1071 N N   . LEU A 1 141 ? -7.35518  0.07227   49.80793 1.000 13.18916 ? 135 LEU A N   1 
ATOM   1072 C CA  . LEU A 1 141 ? -5.89921  0.14656   49.81564 1.000 12.68128 ? 135 LEU A CA  1 
ATOM   1073 C C   . LEU A 1 141 ? -5.26858  -1.24442  49.81223 1.000 12.79122 ? 135 LEU A C   1 
ATOM   1074 O O   . LEU A 1 141 ? -4.21554  -1.44686  49.18626 1.000 14.00709 ? 135 LEU A O   1 
ATOM   1075 C CB  . LEU A 1 141 ? -5.42849  0.96855   51.01655 1.000 12.79082 ? 135 LEU A CB  1 
ATOM   1076 C CG  . LEU A 1 141 ? -3.90639  1.28833   51.00023 1.000 12.33643 ? 135 LEU A CG  1 
ATOM   1077 C CD1 . LEU A 1 141 ? -3.57952  2.21259   49.78949 1.000 14.82934 ? 135 LEU A CD1 1 
ATOM   1078 C CD2 . LEU A 1 141 ? -3.54588  1.96730   52.30501 1.000 15.40589 ? 135 LEU A CD2 1 
ATOM   1079 N N   . LYS A 1 142 ? -5.90123  -2.22971  50.45192 1.000 13.53885 ? 136 LYS A N   1 
ATOM   1080 C CA  . LYS A 1 142 ? -5.36508  -3.59743  50.38567 1.000 13.37562 ? 136 LYS A CA  1 
ATOM   1081 C C   . LYS A 1 142 ? -5.27587  -4.05548  48.92659 1.000 13.95654 ? 136 LYS A C   1 
ATOM   1082 O O   . LYS A 1 142 ? -4.27196  -4.63503  48.49324 1.000 15.62645 ? 136 LYS A O   1 
ATOM   1083 C CB  . LYS A 1 142 ? -6.24800  -4.54434  51.19676 1.000 12.21404 ? 136 LYS A CB  1 
ATOM   1084 C CG  . LYS A 1 142 ? -5.80900  -5.98789  51.05259 1.000 13.32451 ? 136 LYS A CG  1 
ATOM   1085 C CD  . LYS A 1 142 ? -6.75467  -6.97811  51.75360 1.000 14.89722 ? 136 LYS A CD  1 
ATOM   1086 C CE  . LYS A 1 142 ? -6.30132  -8.43714  51.52292 1.000 15.46473 ? 136 LYS A CE  1 
ATOM   1087 N NZ  . LYS A 1 142 ? -7.31852  -9.40577  52.07356 1.000 15.89830 ? 136 LYS A NZ  1 
ATOM   1088 N N   . TYR A 1 143 ? -6.30477  -3.74855  48.14615 1.000 13.52590 ? 137 TYR A N   1 
ATOM   1089 C CA  . TYR A 1 143 ? -6.32043  -4.14479  46.74170 1.000 13.67191 ? 137 TYR A CA  1 
ATOM   1090 C C   . TYR A 1 143 ? -5.22460  -3.41440  45.97561 1.000 15.33724 ? 137 TYR A C   1 
ATOM   1091 O O   . TYR A 1 143 ? -4.45862  -4.02805  45.22103 1.000 16.55919 ? 137 TYR A O   1 
ATOM   1092 C CB  . TYR A 1 143 ? -7.69938  -3.84523  46.13590 1.000 14.57533 ? 137 TYR A CB  1 
ATOM   1093 C CG  . TYR A 1 143 ? -7.84527  -4.22222  44.67523 1.000 14.69941 ? 137 TYR A CG  1 
ATOM   1094 C CD1 . TYR A 1 143 ? -7.49697  -3.33727  43.66262 1.000 14.70436 ? 137 TYR A CD1 1 
ATOM   1095 C CD2 . TYR A 1 143 ? -8.37545  -5.47218  44.30704 1.000 15.36635 ? 137 TYR A CD2 1 
ATOM   1096 C CE1 . TYR A 1 143 ? -7.63154  -3.68525  42.32681 1.000 18.13841 ? 137 TYR A CE1 1 
ATOM   1097 C CE2 . TYR A 1 143 ? -8.51791  -5.84374  42.96634 1.000 17.09233 ? 137 TYR A CE2 1 
ATOM   1098 C CZ  . TYR A 1 143 ? -8.15172  -4.91310  41.99072 1.000 18.01762 ? 137 TYR A CZ  1 
ATOM   1099 O OH  . TYR A 1 143 ? -8.29120  -5.20378  40.67452 1.000 19.01945 ? 137 TYR A OH  1 
ATOM   1100 N N   . ILE A 1 144 ? -5.10859  -2.10768  46.19757 1.000 15.09028 ? 138 ILE A N   1 
ATOM   1101 C CA  . ILE A 1 144 ? -4.09528  -1.32362  45.49641 1.000 14.49463 ? 138 ILE A CA  1 
ATOM   1102 C C   . ILE A 1 144 ? -2.70202  -1.86897  45.79370 1.000 14.55106 ? 138 ILE A C   1 
ATOM   1103 O O   . ILE A 1 144 ? -1.89626  -2.13481  44.88462 1.000 15.05296 ? 138 ILE A O   1 
ATOM   1104 C CB  . ILE A 1 144 ? -4.20638  0.14725   45.90257 1.000 13.00835 ? 138 ILE A CB  1 
ATOM   1105 C CG1 . ILE A 1 144 ? -5.61031  0.70478   45.56921 1.000 14.29903 ? 138 ILE A CG1 1 
ATOM   1106 C CG2 . ILE A 1 144 ? -3.05243  0.98592   45.26038 1.000 15.07873 ? 138 ILE A CG2 1 
ATOM   1107 C CD1 . ILE A 1 144 ? -5.86030  2.06444   46.22219 1.000 14.48224 ? 138 ILE A CD1 1 
ATOM   1108 N N   . HIS A 1 145 ? -2.40746  -2.05343  47.06153 1.000 13.61753 ? 139 HIS A N   1 
ATOM   1109 C CA  . HIS A 1 145 ? -1.08066  -2.52686  47.46613 1.000 13.44395 ? 139 HIS A CA  1 
ATOM   1110 C C   . HIS A 1 145 ? -0.82922  -3.94648  46.99608 1.000 14.88255 ? 139 HIS A C   1 
ATOM   1111 O O   . HIS A 1 145 ? 0.31933   -4.29078  46.66064 1.000 16.15704 ? 139 HIS A O   1 
ATOM   1112 C CB  . HIS A 1 145 ? -0.93058  -2.43817  48.99498 1.000 12.79726 ? 139 HIS A CB  1 
ATOM   1113 C CG  . HIS A 1 145 ? -0.65153  -1.04377  49.45696 1.000 13.67154 ? 139 HIS A CG  1 
ATOM   1114 N ND1 . HIS A 1 145 ? -0.41319  -0.70186  50.77871 1.000 14.56526 ? 139 HIS A ND1 1 
ATOM   1115 C CD2 . HIS A 1 145 ? -0.55302  0.10332   48.74645 1.000 14.44849 ? 139 HIS A CD2 1 
ATOM   1116 C CE1 . HIS A 1 145 ? -0.18971  0.59868   50.86162 1.000 15.04839 ? 139 HIS A CE1 1 
ATOM   1117 N NE2 . HIS A 1 145 ? -0.29359  1.11682   49.64218 1.000 15.14794 ? 139 HIS A NE2 1 
ATOM   1118 N N   . SER A 1 146 ? -1.88773  -4.76882  46.91349 1.000 15.45997 ? 140 SER A N   1 
ATOM   1119 C CA  . SER A 1 146 ? -1.70388  -6.13877  46.42249 1.000 15.70177 ? 140 SER A CA  1 
ATOM   1120 C C   . SER A 1 146 ? -1.33508  -6.15955  44.93497 1.000 16.30727 ? 140 SER A C   1 
ATOM   1121 O O   . SER A 1 146 ? -0.82232  -7.17047  44.44204 1.000 19.74706 ? 140 SER A O   1 
ATOM   1122 C CB  . SER A 1 146 ? -2.97996  -6.96754  46.64016 1.000 15.83819 ? 140 SER A CB  1 
ATOM   1123 O OG  . SER A 1 146 ? -3.96542  -6.59929  45.67502 1.000 18.14141 ? 140 SER A OG  1 
ATOM   1124 N N   . ALA A 1 147 ? -1.60322  -5.07075  44.20821 1.000 17.13123 ? 141 ALA A N   1 
ATOM   1125 C CA  . ALA A 1 147 ? -1.18168  -4.93401  42.81888 1.000 17.98600 ? 141 ALA A CA  1 
ATOM   1126 C C   . ALA A 1 147 ? 0.20614   -4.34732  42.72305 1.000 19.00995 ? 141 ALA A C   1 
ATOM   1127 O O   . ALA A 1 147 ? 0.64503   -4.00771  41.62016 1.000 21.91532 ? 141 ALA A O   1 
ATOM   1128 C CB  . ALA A 1 147 ? -2.16227  -4.03708  42.04416 1.000 18.95223 ? 141 ALA A CB  1 
ATOM   1129 N N   . ASN A 1 148 ? 0.88049   -4.16237  43.85405 1.000 19.31092 ? 142 ASN A N   1 
ATOM   1130 C CA  . ASN A 1 148 ? 2.22114   -3.54009  43.88424 1.000 19.32864 ? 142 ASN A CA  1 
ATOM   1131 C C   . ASN A 1 148 ? 2.18045   -2.07934  43.46672 1.000 17.95899 ? 142 ASN A C   1 
ATOM   1132 O O   . ASN A 1 148 ? 3.17206   -1.54014  42.98497 1.000 19.38495 ? 142 ASN A O   1 
ATOM   1133 C CB  . ASN A 1 148 ? 3.22312   -4.29905  43.01739 1.000 22.79735 ? 142 ASN A CB  1 
ATOM   1134 C CG  . ASN A 1 148 ? 4.63720   -4.11403  43.49326 0.739 24.28609 ? 142 ASN A CG  1 
ATOM   1135 O OD1 . ASN A 1 148 ? 4.88856   -4.02249  44.68848 0.710 23.80639 ? 142 ASN A OD1 1 
ATOM   1136 N ND2 . ASN A 1 148 ? 5.56163   -3.99488  42.55877 0.594 27.34373 ? 142 ASN A ND2 1 
ATOM   1137 N N   . VAL A 1 149 ? 1.05269   -1.41447  43.69499 1.000 18.18441 ? 143 VAL A N   1 
ATOM   1138 C CA  . VAL A 1 149 ? 0.86493   -0.02111  43.33024 1.000 17.79290 ? 143 VAL A CA  1 
ATOM   1139 C C   . VAL A 1 149 ? 0.72797   0.79272   44.61460 1.000 15.97316 ? 143 VAL A C   1 
ATOM   1140 O O   . VAL A 1 149 ? 0.16165   0.32052   45.60539 1.000 16.53113 ? 143 VAL A O   1 
ATOM   1141 C CB  . VAL A 1 149 ? -0.36922  0.14574   42.40974 1.000 17.36753 ? 143 VAL A CB  1 
ATOM   1142 C CG1 . VAL A 1 149 ? -0.73583  1.63437   42.22959 1.000 19.21496 ? 143 VAL A CG1 1 
ATOM   1143 C CG2 . VAL A 1 149 ? -0.05765  -0.48731  41.03715 1.000 18.97443 ? 143 VAL A CG2 1 
ATOM   1144 N N   . LEU A 1 150 ? 1.24147   2.00701   44.58470 1.000 15.62594 ? 144 LEU A N   1 
ATOM   1145 C CA  . LEU A 1 150 ? 1.11893   2.99955   45.64283 1.000 15.42205 ? 144 LEU A CA  1 
ATOM   1146 C C   . LEU A 1 150 ? 0.22337   4.10717   45.12536 1.000 15.95413 ? 144 LEU A C   1 
ATOM   1147 O O   . LEU A 1 150 ? 0.43163   4.57714   44.00861 1.000 17.55600 ? 144 LEU A O   1 
ATOM   1148 C CB  . LEU A 1 150 ? 2.48854   3.59306   45.97632 1.000 18.68125 ? 144 LEU A CB  1 
ATOM   1149 C CG  . LEU A 1 150 ? 3.59137   2.56650   46.14463 1.000 19.23133 ? 144 LEU A CG  1 
ATOM   1150 C CD1 . LEU A 1 150 ? 4.90708   3.28822   46.29702 1.000 19.03575 ? 144 LEU A CD1 1 
ATOM   1151 C CD2 . LEU A 1 150 ? 3.26633   1.71771   47.38271 1.000 19.44284 ? 144 LEU A CD2 1 
ATOM   1152 N N   . HIS A 1 151 ? -0.74748  4.55378   45.93369 1.000 15.50868 ? 145 HIS A N   1 
ATOM   1153 C CA  . HIS A 1 151 ? -1.59765  5.64306   45.48269 1.000 14.56085 ? 145 HIS A CA  1 
ATOM   1154 C C   . HIS A 1 151 ? -0.84960  6.97204   45.52293 1.000 15.83002 ? 145 HIS A C   1 
ATOM   1155 O O   . HIS A 1 151 ? -0.87257  7.74230   44.55700 1.000 15.88318 ? 145 HIS A O   1 
ATOM   1156 C CB  . HIS A 1 151 ? -2.86522  5.69587   46.35006 1.000 13.16582 ? 145 HIS A CB  1 
ATOM   1157 C CG  . HIS A 1 151 ? -3.83133  6.75756   45.93782 1.000 13.41822 ? 145 HIS A CG  1 
ATOM   1158 N ND1 . HIS A 1 151 ? -3.62913  8.09293   46.20994 1.000 14.85420 ? 145 HIS A ND1 1 
ATOM   1159 C CD2 . HIS A 1 151 ? -5.03278  6.67632   45.30618 1.000 14.63443 ? 145 HIS A CD2 1 
ATOM   1160 C CE1 . HIS A 1 151 ? -4.64540  8.79746   45.73602 1.000 15.47148 ? 145 HIS A CE1 1 
ATOM   1161 N NE2 . HIS A 1 151 ? -5.52945  7.95702   45.20863 1.000 15.39433 ? 145 HIS A NE2 1 
ATOM   1162 N N   . ARG A 1 152 ? -0.20353  7.24967   46.64160 1.000 14.93067 ? 146 ARG A N   1 
ATOM   1163 C CA  . ARG A 1 152 ? 0.70479   8.37390   46.88099 1.000 14.92042 ? 146 ARG A CA  1 
ATOM   1164 C C   . ARG A 1 152 ? 0.01939   9.72138   46.99803 1.000 17.46582 ? 146 ARG A C   1 
ATOM   1165 O O   . ARG A 1 152 ? 0.70369   10.72146  47.04398 1.000 20.66996 ? 146 ARG A O   1 
ATOM   1166 C CB  . ARG A 1 152 ? 1.78410   8.46294   45.79703 1.000 16.41081 ? 146 ARG A CB  1 
ATOM   1167 C CG  . ARG A 1 152 ? 2.63127   7.21205   45.83420 1.000 20.25328 ? 146 ARG A CG  1 
ATOM   1168 C CD  . ARG A 1 152 ? 3.62075   7.11352   44.69374 1.000 24.70333 ? 146 ARG A CD  1 
ATOM   1169 N NE  . ARG A 1 152 ? 4.78962   7.87518   45.01817 0.877 29.19643 ? 146 ARG A NE  1 
ATOM   1170 C CZ  . ARG A 1 152 ? 5.24515   8.88394   44.30238 0.993 31.73614 ? 146 ARG A CZ  1 
ATOM   1171 N NH1 . ARG A 1 152 ? 4.57446   9.35883   43.26341 0.746 32.75193 ? 146 ARG A NH1 1 
ATOM   1172 N NH2 . ARG A 1 152 ? 6.43402   9.38456   44.59420 1.000 31.01399 ? 146 ARG A NH2 1 
ATOM   1173 N N   . ASP A 1 153 ? -1.30946  9.80018   47.00890 1.000 15.00431 ? 147 ASP A N   1 
ATOM   1174 C CA  . ASP A 1 153 ? -1.94133  11.09474  47.27813 1.000 15.38672 ? 147 ASP A CA  1 
ATOM   1175 C C   . ASP A 1 153 ? -3.25467  10.89364  47.97695 1.000 15.29255 ? 147 ASP A C   1 
ATOM   1176 O O   . ASP A 1 153 ? -4.24305  11.57459  47.67371 1.000 15.94836 ? 147 ASP A O   1 
ATOM   1177 C CB  . ASP A 1 153 ? -2.15060  11.92647  46.00444 1.000 17.14274 ? 147 ASP A CB  1 
ATOM   1178 C CG  . ASP A 1 153 ? -2.24194  13.42214  46.30305 1.000 19.62785 ? 147 ASP A CG  1 
ATOM   1179 O OD1 . ASP A 1 153 ? -1.83947  13.88407  47.41556 1.000 19.09240 ? 147 ASP A OD1 1 
ATOM   1180 O OD2 . ASP A 1 153 ? -2.71841  14.16154  45.42303 1.000 21.72501 ? 147 ASP A OD2 1 
ATOM   1181 N N   . LEU A 1 154 ? -3.27636  9.98745   48.95384 1.000 14.82711 ? 148 LEU A N   1 
ATOM   1182 C CA  . LEU A 1 154 ? -4.50519  9.77019   49.72676 1.000 14.17848 ? 148 LEU A CA  1 
ATOM   1183 C C   . LEU A 1 154 ? -4.75660  10.98853  50.60694 1.000 15.99876 ? 148 LEU A C   1 
ATOM   1184 O O   . LEU A 1 154 ? -3.84423  11.46049  51.29709 1.000 16.81196 ? 148 LEU A O   1 
ATOM   1185 C CB  . LEU A 1 154 ? -4.39615  8.52515   50.58838 1.000 14.52692 ? 148 LEU A CB  1 
ATOM   1186 C CG  . LEU A 1 154 ? -4.34062  7.23083   49.74207 1.000 14.05259 ? 148 LEU A CG  1 
ATOM   1187 C CD1 . LEU A 1 154 ? -3.97509  6.05682   50.66727 1.000 16.08894 ? 148 LEU A CD1 1 
ATOM   1188 C CD2 . LEU A 1 154 ? -5.65349  6.98342   48.94532 1.000 15.05348 ? 148 LEU A CD2 1 
ATOM   1189 N N   . LYS A 1 155 ? -5.97721  11.51004  50.55491 1.000 13.98515 ? 149 LYS A N   1 
ATOM   1190 C CA  . LYS A 1 155 ? -6.37872  12.66306  51.33908 1.000 14.59891 ? 149 LYS A CA  1 
ATOM   1191 C C   . LYS A 1 155 ? -7.89972  12.77520  51.23620 1.000 13.85265 ? 149 LYS A C   1 
ATOM   1192 O O   . LYS A 1 155 ? -8.50281  12.11236  50.39290 1.000 15.38222 ? 149 LYS A O   1 
ATOM   1193 C CB  . LYS A 1 155 ? -5.71499  13.95135  50.83278 1.000 15.94447 ? 149 LYS A CB  1 
ATOM   1194 C CG  . LYS A 1 155 ? -6.00187  14.23885  49.36413 1.000 16.92207 ? 149 LYS A CG  1 
ATOM   1195 C CD  . LYS A 1 155 ? -5.25262  15.46567  48.92780 1.000 18.91187 ? 149 LYS A CD  1 
ATOM   1196 C CE  . LYS A 1 155 ? -5.39750  15.65358  47.43762 1.000 20.42459 ? 149 LYS A CE  1 
ATOM   1197 N NZ  . LYS A 1 155 ? -4.79914  16.94397  46.93751 1.000 23.36907 ? 149 LYS A NZ  1 
ATOM   1198 N N   . PRO A 1 156 ? -8.54033  13.55011  52.11985 1.000 14.32690 ? 150 PRO A N   1 
ATOM   1199 C CA  . PRO A 1 156 ? -10.02000 13.52065  52.14654 1.000 13.82168 ? 150 PRO A CA  1 
ATOM   1200 C C   . PRO A 1 156 ? -10.67226 13.84635  50.80980 1.000 16.19432 ? 150 PRO A C   1 
ATOM   1201 O O   . PRO A 1 156 ? -11.69898 13.22632  50.47297 1.000 16.05785 ? 150 PRO A O   1 
ATOM   1202 C CB  . PRO A 1 156 ? -10.34687 14.55661  53.24102 1.000 15.78481 ? 150 PRO A CB  1 
ATOM   1203 C CG  . PRO A 1 156 ? -9.14298  14.46438  54.18498 1.000 15.29818 ? 150 PRO A CG  1 
ATOM   1204 C CD  . PRO A 1 156 ? -7.99250  14.33196  53.25084 1.000 15.86307 ? 150 PRO A CD  1 
ATOM   1205 N N   . SER A 1 157 ? -10.11889 14.79077  50.01762 1.000 16.27997 ? 151 SER A N   1 
ATOM   1206 C CA  . SER A 1 157 ? -10.80519 15.16233  48.77005 1.000 17.95662 ? 151 SER A CA  1 
ATOM   1207 C C   . SER A 1 157 ? -10.71236 14.04870  47.71994 1.000 18.01575 ? 151 SER A C   1 
ATOM   1208 O O   . SER A 1 157 ? -11.45867 14.08949  46.72120 1.000 19.63005 ? 151 SER A O   1 
ATOM   1209 C CB  . SER A 1 157 ? -10.23457 16.48388  48.20648 1.000 19.11215 ? 151 SER A CB  1 
ATOM   1210 O OG  . SER A 1 157 ? -8.86618  16.28414  47.81189 1.000 20.17968 ? 151 SER A OG  1 
ATOM   1211 N N   . ASN A 1 158 ? -9.87648  13.03003  47.94416 1.000 17.96879 ? 152 ASN A N   1 
ATOM   1212 C CA  . ASN A 1 158 ? -9.79629  11.88031  47.05007 1.000 15.63070 ? 152 ASN A CA  1 
ATOM   1213 C C   . ASN A 1 158 ? -10.63441 10.70488  47.53724 1.000 16.34608 ? 152 ASN A C   1 
ATOM   1214 O O   . ASN A 1 158 ? -10.52179 9.58581   47.00689 1.000 17.42868 ? 152 ASN A O   1 
ATOM   1215 C CB  . ASN A 1 158 ? -8.32908  11.48029  46.85241 1.000 17.60778 ? 152 ASN A CB  1 
ATOM   1216 C CG  . ASN A 1 158 ? -7.65939  12.34702  45.78047 1.000 17.85617 ? 152 ASN A CG  1 
ATOM   1217 O OD1 . ASN A 1 158 ? -8.37849  12.93984  44.95442 1.000 19.54832 ? 152 ASN A OD1 1 
ATOM   1218 N ND2 . ASN A 1 158 ? -6.31684  12.46283  45.78635 1.000 17.99725 ? 152 ASN A ND2 1 
ATOM   1219 N N   . LEU A 1 159 ? -11.48487 10.92234  48.53180 1.000 14.90386 ? 153 LEU A N   1 
ATOM   1220 C CA  . LEU A 1 159 ? -12.32702 9.85136   49.06266 1.000 14.18745 ? 153 LEU A CA  1 
ATOM   1221 C C   . LEU A 1 159 ? -13.75978 10.29302  48.82996 1.000 15.12108 ? 153 LEU A C   1 
ATOM   1222 O O   . LEU A 1 159 ? -14.26247 11.21374  49.51193 1.000 18.07215 ? 153 LEU A O   1 
ATOM   1223 C CB  . LEU A 1 159 ? -12.02527 9.58773   50.54269 1.000 13.94265 ? 153 LEU A CB  1 
ATOM   1224 C CG  . LEU A 1 159 ? -10.53140 9.28731   50.84426 1.000 14.24172 ? 153 LEU A CG  1 
ATOM   1225 C CD1 . LEU A 1 159 ? -10.28861 9.15043   52.38853 1.000 15.07093 ? 153 LEU A CD1 1 
ATOM   1226 C CD2 . LEU A 1 159 ? -10.12100 7.98761   50.13089 1.000 15.79652 ? 153 LEU A CD2 1 
ATOM   1227 N N   . LEU A 1 160 ? -14.41084 9.64210   47.87856 1.000 14.65595 ? 154 LEU A N   1 
ATOM   1228 C CA  . LEU A 1 160 ? -15.76812 9.98701   47.50267 1.000 14.82208 ? 154 LEU A CA  1 
ATOM   1229 C C   . LEU A 1 160 ? -16.74860 9.09626   48.23850 1.000 16.74975 ? 154 LEU A C   1 
ATOM   1230 O O   . LEU A 1 160 ? -16.46028 7.93276   48.52483 1.000 15.34469 ? 154 LEU A O   1 
ATOM   1231 C CB  . LEU A 1 160 ? -15.97752 9.78455   45.98340 1.000 15.20059 ? 154 LEU A CB  1 
ATOM   1232 C CG  . LEU A 1 160 ? -14.92191 10.44681  45.11872 1.000 17.48003 ? 154 LEU A CG  1 
ATOM   1233 C CD1 . LEU A 1 160 ? -15.14802 10.13514  43.62069 1.000 18.60458 ? 154 LEU A CD1 1 
ATOM   1234 C CD2 . LEU A 1 160 ? -14.95020 11.98170  45.39220 1.000 20.40982 ? 154 LEU A CD2 1 
ATOM   1235 N N   . LEU A 1 161 ? -17.91283 9.66516   48.57848 1.000 17.48894 ? 155 LEU A N   1 
ATOM   1236 C CA  . LEU A 1 161 ? -18.96410 8.96180   49.30751 1.000 17.62916 ? 155 LEU A CA  1 
ATOM   1237 C C   . LEU A 1 161 ? -20.28297 9.04634   48.55842 1.000 18.90411 ? 155 LEU A C   1 
ATOM   1238 O O   . LEU A 1 161 ? -20.63634 10.09953  48.02039 1.000 20.87418 ? 155 LEU A O   1 
ATOM   1239 C CB  . LEU A 1 161 ? -19.15276 9.54937   50.73229 1.000 18.99031 ? 155 LEU A CB  1 
ATOM   1240 C CG  . LEU A 1 161 ? -17.78901 9.45774   51.39645 1.000 23.00524 ? 155 LEU A CG  1 
ATOM   1241 C CD1 . LEU A 1 161 ? -17.49677 10.58983  52.29126 1.000 28.06469 ? 155 LEU A CD1 1 
ATOM   1242 C CD2 . LEU A 1 161 ? -17.62307 8.07728   52.03106 1.000 23.86381 ? 155 LEU A CD2 1 
ATOM   1243 N N   . ASN A 1 162 ? -21.02428 7.94127   48.53242 1.000 18.52107 ? 156 ASN A N   1 
ATOM   1244 C CA  . ASN A 1 162 ? -22.36805 8.02312   47.97633 1.000 20.73303 ? 156 ASN A CA  1 
ATOM   1245 C C   . ASN A 1 162 ? -23.36613 8.29438   49.09504 1.000 22.45236 ? 156 ASN A C   1 
ATOM   1246 O O   . ASN A 1 162 ? -23.00587 8.58122   50.23576 1.000 22.61074 ? 156 ASN A O   1 
ATOM   1247 C CB  . ASN A 1 162 ? -22.69518 6.78059   47.15750 1.000 23.31324 ? 156 ASN A CB  1 
ATOM   1248 C CG  . ASN A 1 162 ? -22.87467 5.53833   47.98918 1.000 26.05361 ? 156 ASN A CG  1 
ATOM   1249 O OD1 . ASN A 1 162 ? -22.90718 5.57232   49.21175 1.000 24.98816 ? 156 ASN A OD1 1 
ATOM   1250 N ND2 . ASN A 1 162 ? -22.98452 4.40911   47.30868 1.000 29.84374 ? 156 ASN A ND2 1 
ATOM   1251 N N   . THR A 1 163 ? -24.64573 8.24600   48.75408 1.000 23.99569 ? 157 THR A N   1 
ATOM   1252 C CA  . THR A 1 163 ? -25.66332 8.69209   49.69148 1.000 24.10276 ? 157 THR A CA  1 
ATOM   1253 C C   . THR A 1 163 ? -25.80395 7.77402   50.90496 1.000 25.07815 ? 157 THR A C   1 
ATOM   1254 O O   . THR A 1 163 ? -26.35028 8.20167   51.94029 1.000 24.43789 ? 157 THR A O   1 
ATOM   1255 C CB  A THR A 1 163 ? -26.98682 8.79281   48.94781 0.264 24.44902 ? 157 THR A CB  1 
ATOM   1256 C CB  B THR A 1 163 ? -26.98677 8.88411   48.92698 0.736 27.50106 ? 157 THR A CB  1 
ATOM   1257 O OG1 A THR A 1 163 ? -26.83360 9.68625   47.83745 0.264 23.97493 ? 157 THR A OG1 1 
ATOM   1258 O OG1 B THR A 1 163 ? -27.77732 9.83460   49.60447 0.736 30.83983 ? 157 THR A OG1 1 
ATOM   1259 C CG2 A THR A 1 163 ? -28.01791 9.27401   49.83640 0.264 24.23106 ? 157 THR A CG2 1 
ATOM   1260 C CG2 B THR A 1 163 ? -27.77183 7.62458   48.74736 0.736 25.04814 ? 157 THR A CG2 1 
ATOM   1261 N N   . THR A 1 164 ? -25.31216 6.53988   50.81040 1.000 25.26028 ? 158 THR A N   1 
ATOM   1262 C CA  . THR A 1 164 ? -25.37251 5.58811   51.92052 1.000 25.56657 ? 158 THR A CA  1 
ATOM   1263 C C   . THR A 1 164 ? -23.97984 5.34967   52.50270 1.000 24.92123 ? 158 THR A C   1 
ATOM   1264 O O   . THR A 1 164 ? -23.72733 4.35120   53.14814 1.000 25.66840 ? 158 THR A O   1 
ATOM   1265 C CB  . THR A 1 164 ? -25.95709 4.25076   51.47270 1.000 28.23176 ? 158 THR A CB  1 
ATOM   1266 O OG1 . THR A 1 164 ? -25.39155 3.87978   50.20831 1.000 29.25715 ? 158 THR A OG1 1 
ATOM   1267 C CG2 . THR A 1 164 ? -27.46804 4.39213   51.25950 1.000 32.10766 ? 158 THR A CG2 1 
HETATM 1268 N N   . CME A 1 165 ? -23.09323 6.29827   52.26440 1.000 22.94492 ? 159 CME A N   1 
HETATM 1269 C CA  . CME A 1 165 ? -21.76448 6.34732   52.84703 1.000 22.95029 ? 159 CME A CA  1 
HETATM 1270 C CB  . CME A 1 165 ? -21.81661 6.36381   54.41019 1.000 26.17849 ? 159 CME A CB  1 
HETATM 1271 S SG  . CME A 1 165 ? -22.71961 7.80318   55.04802 0.977 29.59946 ? 159 CME A SG  1 
HETATM 1272 S SD  . CME A 1 165 ? -21.57339 9.50806   54.51345 0.757 29.48709 ? 159 CME A SD  1 
HETATM 1273 C CE  . CME A 1 165 ? -22.21646 10.25562  53.06636 1.000 28.75942 ? 159 CME A CE  1 
HETATM 1274 C CZ  . CME A 1 165 ? -23.66156 10.62976  53.16645 1.000 30.66675 ? 159 CME A CZ  1 
HETATM 1275 O OH  . CME A 1 165 ? -23.74147 11.58005  54.22152 0.912 30.24244 ? 159 CME A OH  1 
HETATM 1276 C C   . CME A 1 165 ? -20.83755 5.23280   52.37499 1.000 21.35364 ? 159 CME A C   1 
HETATM 1277 O O   . CME A 1 165 ? -19.84044 4.90591   53.02268 1.000 21.76625 ? 159 CME A O   1 
ATOM   1278 N N   . ASP A 1 166 ? -21.12759 4.67319   51.20083 1.000 19.29834 ? 160 ASP A N   1 
ATOM   1279 C CA  . ASP A 1 166 ? -20.13978 3.77783   50.58105 1.000 18.90321 ? 160 ASP A CA  1 
ATOM   1280 C C   . ASP A 1 166 ? -19.02275 4.64842   50.00928 1.000 17.13284 ? 160 ASP A C   1 
ATOM   1281 O O   . ASP A 1 166 ? -19.29285 5.71238   49.45929 1.000 18.98512 ? 160 ASP A O   1 
ATOM   1282 C CB  . ASP A 1 166 ? -20.75780 2.91609   49.50152 1.000 23.28768 ? 160 ASP A CB  1 
ATOM   1283 C CG  . ASP A 1 166 ? -21.87426 2.03340   50.03720 1.000 24.94523 ? 160 ASP A CG  1 
ATOM   1284 O OD1 . ASP A 1 166 ? -21.66948 1.32841   51.05701 0.660 28.42539 ? 160 ASP A OD1 1 
ATOM   1285 O OD2 . ASP A 1 166 ? -22.99118 2.15994   49.53016 0.576 23.93567 ? 160 ASP A OD2 1 
ATOM   1286 N N   . LEU A 1 167 ? -17.78068 4.21090   50.15284 1.000 16.38010 ? 161 LEU A N   1 
ATOM   1287 C CA  . LEU A 1 167 ? -16.61098 5.03663   49.89889 1.000 15.63762 ? 161 LEU A CA  1 
ATOM   1288 C C   . LEU A 1 167 ? -15.81327 4.50352   48.71830 1.000 15.21744 ? 161 LEU A C   1 
ATOM   1289 O O   . LEU A 1 167 ? -15.64295 3.29114   48.56562 1.000 17.86620 ? 161 LEU A O   1 
ATOM   1290 C CB  . LEU A 1 167 ? -15.73394 5.08358   51.15601 1.000 15.09326 ? 161 LEU A CB  1 
ATOM   1291 C CG  . LEU A 1 167 ? -14.42725 5.86382   51.06341 1.000 15.35317 ? 161 LEU A CG  1 
ATOM   1292 C CD1 . LEU A 1 167 ? -14.06977 6.41496   52.50848 1.000 17.77643 ? 161 LEU A CD1 1 
ATOM   1293 C CD2 . LEU A 1 167 ? -13.26461 4.99087   50.51375 1.000 16.42966 ? 161 LEU A CD2 1 
ATOM   1294 N N   . LYS A 1 168 ? -15.35469 5.41204   47.85866 1.000 14.88470 ? 162 LYS A N   1 
ATOM   1295 C CA  . LYS A 1 168 ? -14.47357 5.03176   46.75332 1.000 14.41097 ? 162 LYS A CA  1 
ATOM   1296 C C   . LYS A 1 168 ? -13.26761 5.96425   46.65646 1.000 15.90620 ? 162 LYS A C   1 
ATOM   1297 O O   . LYS A 1 168 ? -13.39478 7.18517   46.77160 1.000 16.66293 ? 162 LYS A O   1 
ATOM   1298 C CB  . LYS A 1 168 ? -15.21580 5.05164   45.41961 1.000 16.77011 ? 162 LYS A CB  1 
ATOM   1299 C CG  . LYS A 1 168 ? -16.36891 4.01335   45.29308 1.000 18.82363 ? 162 LYS A CG  1 
ATOM   1300 C CD  . LYS A 1 168 ? -16.95770 4.09726   43.91399 1.000 20.77001 ? 162 LYS A CD  1 
ATOM   1301 C CE  . LYS A 1 168 ? -18.27133 3.32499   43.72518 1.000 23.57111 ? 162 LYS A CE  1 
ATOM   1302 N NZ  . LYS A 1 168 ? -18.19623 1.90124   44.13225 1.000 25.27973 ? 162 LYS A NZ  1 
ATOM   1303 N N   . ILE A 1 169 ? -12.10698 5.37888   46.39818 1.000 14.33677 ? 163 ILE A N   1 
ATOM   1304 C CA  . ILE A 1 169 ? -10.85049 6.11783   46.28107 1.000 14.11147 ? 163 ILE A CA  1 
ATOM   1305 C C   . ILE A 1 169 ? -10.71627 6.65723   44.86749 1.000 14.22509 ? 163 ILE A C   1 
ATOM   1306 O O   . ILE A 1 169 ? -10.86764 5.90998   43.89115 1.000 14.87131 ? 163 ILE A O   1 
ATOM   1307 C CB  . ILE A 1 169 ? -9.66567  5.18762   46.60057 1.000 12.31270 ? 163 ILE A CB  1 
ATOM   1308 C CG1 . ILE A 1 169 ? -9.75244  4.69942   48.05905 1.000 13.99827 ? 163 ILE A CG1 1 
ATOM   1309 C CG2 . ILE A 1 169 ? -8.34583  5.92320   46.29828 1.000 14.37907 ? 163 ILE A CG2 1 
ATOM   1310 C CD1 . ILE A 1 169 ? -8.83829  3.53267   48.38047 1.000 15.02844 ? 163 ILE A CD1 1 
ATOM   1311 N N   . CYS A 1 170 ? -10.42560 7.95458   44.75272 1.000 14.95485 ? 164 CYS A N   1 
ATOM   1312 C CA  . CYS A 1 170 ? -10.27680 8.63882   43.49161 1.000 15.20298 ? 164 CYS A CA  1 
ATOM   1313 C C   . CYS A 1 170 ? -8.83282  9.07797   43.28713 1.000 16.26111 ? 164 CYS A C   1 
ATOM   1314 O O   . CYS A 1 170 ? -8.04470  9.15102   44.21108 1.000 16.18142 ? 164 CYS A O   1 
ATOM   1315 C CB  . CYS A 1 170 ? -11.20181 9.88010   43.43450 1.000 15.57166 ? 164 CYS A CB  1 
ATOM   1316 S SG  . CYS A 1 170 ? -11.66877 10.38812  41.79172 1.000 18.69154 ? 164 CYS A SG  1 
ATOM   1317 N N   . ASP A 1 171 ? -8.49995  9.26595   42.01315 1.000 17.19189 ? 165 ASP A N   1 
ATOM   1318 C CA  . ASP A 1 171 ? -7.33366  9.94431   41.43899 1.000 20.50441 ? 165 ASP A CA  1 
ATOM   1319 C C   . ASP A 1 171 ? -6.05582  9.10036   41.57590 1.000 21.48429 ? 165 ASP A C   1 
ATOM   1320 O O   . ASP A 1 171 ? -5.36237  9.11584   42.60521 1.000 22.32870 ? 165 ASP A O   1 
ATOM   1321 C CB  . ASP A 1 171 ? -7.09817  11.30978  42.06465 1.000 20.62144 ? 165 ASP A CB  1 
ATOM   1322 C CG  . ASP A 1 171 ? -5.99059  12.07973  41.34018 0.952 23.20153 ? 165 ASP A CG  1 
ATOM   1323 O OD1 . ASP A 1 171 ? -5.42891  11.56530  40.33862 1.000 24.62280 ? 165 ASP A OD1 1 
ATOM   1324 O OD2 . ASP A 1 171 ? -5.76926  13.24384  41.67194 0.687 25.56970 ? 165 ASP A OD2 1 
ATOM   1325 N N   . PHE A 1 172 ? -5.72381  8.37184   40.52215 1.000 21.15919 ? 166 PHE A N   1 
ATOM   1326 C CA  . PHE A 1 172 ? -4.48769  7.60759   40.48301 1.000 20.89748 ? 166 PHE A CA  1 
ATOM   1327 C C   . PHE A 1 172 ? -3.42313  8.30125   39.64004 1.000 23.94676 ? 166 PHE A C   1 
ATOM   1328 O O   . PHE A 1 172 ? -2.46841  7.67010   39.18200 1.000 24.47226 ? 166 PHE A O   1 
ATOM   1329 C CB  . PHE A 1 172 ? -4.78280  6.18794   39.99852 1.000 19.31369 ? 166 PHE A CB  1 
ATOM   1330 C CG  . PHE A 1 172 ? -5.40668  5.34035   41.08423 1.000 18.26857 ? 166 PHE A CG  1 
ATOM   1331 C CD1 . PHE A 1 172 ? -6.76648  5.45091   41.38033 1.000 18.51418 ? 166 PHE A CD1 1 
ATOM   1332 C CD2 . PHE A 1 172 ? -4.62970  4.48021   41.84862 1.000 17.84932 ? 166 PHE A CD2 1 
ATOM   1333 C CE1 . PHE A 1 172 ? -7.31853  4.70139   42.41909 1.000 19.58304 ? 166 PHE A CE1 1 
ATOM   1334 C CE2 . PHE A 1 172 ? -5.17980  3.73898   42.85243 1.000 17.67314 ? 166 PHE A CE2 1 
ATOM   1335 C CZ  . PHE A 1 172 ? -6.51787  3.85195   43.14106 1.000 18.84237 ? 166 PHE A CZ  1 
ATOM   1336 N N   . GLY A 1 173 ? -3.54225  9.60431   39.46549 1.000 24.03721 ? 167 GLY A N   1 
ATOM   1337 C CA  . GLY A 1 173 ? -2.57123  10.26849  38.61512 1.000 24.87455 ? 167 GLY A CA  1 
ATOM   1338 C C   . GLY A 1 173 ? -1.20197  10.40435  39.24020 1.000 24.55747 ? 167 GLY A C   1 
ATOM   1339 O O   . GLY A 1 173 ? -0.24069  10.72626  38.53929 1.000 24.29422 ? 167 GLY A O   1 
ATOM   1340 N N   . LEU A 1 174 ? -1.08219  10.17070  40.53576 1.000 21.96122 ? 168 LEU A N   1 
ATOM   1341 C CA  . LEU A 1 174 ? 0.19291   10.30177  41.20534 1.000 23.66719 ? 168 LEU A CA  1 
ATOM   1342 C C   . LEU A 1 174 ? 0.71577   8.90716   41.58173 1.000 21.59770 ? 168 LEU A C   1 
ATOM   1343 O O   . LEU A 1 174 ? 1.76275   8.79811   42.24472 1.000 21.04326 ? 168 LEU A O   1 
ATOM   1344 C CB  . LEU A 1 174 ? -0.07519  11.19361  42.41250 1.000 27.45608 ? 168 LEU A CB  1 
ATOM   1345 C CG  . LEU A 1 174 ? 0.10592   12.69795  42.15805 0.887 29.04221 ? 168 LEU A CG  1 
ATOM   1346 C CD1 . LEU A 1 174 ? 0.43589   13.51354  43.41210 0.568 27.74989 ? 168 LEU A CD1 1 
ATOM   1347 C CD2 . LEU A 1 174 ? 1.14131   12.99671  41.11078 0.652 29.30323 ? 168 LEU A CD2 1 
ATOM   1348 N N   . ALA A 1 175 ? -0.02182  7.83693   41.20926 1.000 18.77464 ? 169 ALA A N   1 
ATOM   1349 C CA  . ALA A 1 175 ? 0.33795   6.47959   41.61805 1.000 17.39320 ? 169 ALA A CA  1 
ATOM   1350 C C   . ALA A 1 175 ? 1.61062   6.00422   40.92518 1.000 19.17952 ? 169 ALA A C   1 
ATOM   1351 O O   . ALA A 1 175 ? 1.95495   6.44705   39.82621 1.000 22.29904 ? 169 ALA A O   1 
ATOM   1352 C CB  . ALA A 1 175 ? -0.78145  5.48916   41.30475 1.000 18.67778 ? 169 ALA A CB  1 
ATOM   1353 N N   . ARG A 1 176 ? 2.29212   5.08112   41.58141 1.000 19.40413 ? 170 ARG A N   1 
ATOM   1354 C CA  A ARG A 1 176 ? 3.51107   4.47393   41.06286 0.500 19.90211 ? 170 ARG A CA  1 
ATOM   1355 C CA  B ARG A 1 176 ? 3.50923   4.46788   41.06273 0.500 20.28174 ? 170 ARG A CA  1 
ATOM   1356 C C   . ARG A 1 176 ? 3.55253   3.00182   41.45173 1.000 20.80893 ? 170 ARG A C   1 
ATOM   1357 O O   . ARG A 1 176 ? 2.94337   2.58599   42.41958 1.000 20.76806 ? 170 ARG A O   1 
ATOM   1358 C CB  A ARG A 1 176 ? 4.77347   5.17072   41.60113 0.500 21.34494 ? 170 ARG A CB  1 
ATOM   1359 C CB  B ARG A 1 176 ? 4.79611   5.09050   41.61037 0.500 22.65545 ? 170 ARG A CB  1 
ATOM   1360 C CG  A ARG A 1 176 ? 4.89797   6.65078   41.24571 0.500 23.40214 ? 170 ARG A CG  1 
ATOM   1361 C CG  B ARG A 1 176 ? 5.01661   6.52388   41.26747 0.500 25.17782 ? 170 ARG A CG  1 
ATOM   1362 C CD  A ARG A 1 176 ? 5.38254   6.87318   39.78931 0.500 25.85345 ? 170 ARG A CD  1 
ATOM   1363 C CD  B ARG A 1 176 ? 6.36742   6.98870   41.77850 0.500 27.28674 ? 170 ARG A CD  1 
ATOM   1364 N NE  A ARG A 1 176 ? 5.90663   8.22569   39.59368 0.500 27.30676 ? 170 ARG A NE  1 
ATOM   1365 N NE  B ARG A 1 176 ? 7.47162   6.37816   41.05057 0.500 32.13905 ? 170 ARG A NE  1 
ATOM   1366 C CZ  A ARG A 1 176 ? 5.15005   9.31500   39.58028 0.500 28.34561 ? 170 ARG A CZ  1 
ATOM   1367 C CZ  B ARG A 1 176 ? 7.91115   6.82468   39.88261 0.500 34.72011 ? 170 ARG A CZ  1 
ATOM   1368 N NH1 A ARG A 1 176 ? 3.83149   9.24355   39.69863 0.500 27.30587 ? 170 ARG A NH1 1 
ATOM   1369 N NH1 B ARG A 1 176 ? 7.30295   7.81547   39.24816 0.500 35.87241 ? 170 ARG A NH1 1 
ATOM   1370 N NH2 A ARG A 1 176 ? 5.72582   10.50393  39.43261 0.500 29.84860 ? 170 ARG A NH2 1 
ATOM   1371 N NH2 B ARG A 1 176 ? 8.95823   6.23824   39.31675 0.500 34.81390 ? 170 ARG A NH2 1 
ATOM   1372 N N   . VAL A 1 177 ? 4.33525   2.21843   40.70124 1.000 20.75968 ? 171 VAL A N   1 
ATOM   1373 C CA  . VAL A 1 177 ? 4.63409   0.85872   41.13181 1.000 21.32556 ? 171 VAL A CA  1 
ATOM   1374 C C   . VAL A 1 177 ? 5.63883   0.91921   42.26990 1.000 21.15571 ? 171 VAL A C   1 
ATOM   1375 O O   . VAL A 1 177 ? 6.60372   1.70055   42.23400 1.000 23.27065 ? 171 VAL A O   1 
ATOM   1376 C CB  . VAL A 1 177 ? 5.16145   0.03676   39.94441 1.000 25.10991 ? 171 VAL A CB  1 
ATOM   1377 C CG1 . VAL A 1 177 ? 5.63595   -1.31071  40.39670 1.000 27.26915 ? 171 VAL A CG1 1 
ATOM   1378 C CG2 . VAL A 1 177 ? 4.07207   -0.13018  38.87117 1.000 26.19002 ? 171 VAL A CG2 1 
ATOM   1379 N N   . ALA A 1 178 ? 5.40193   0.12793   43.30873 1.000 22.29482 ? 172 ALA A N   1 
ATOM   1380 C CA  . ALA A 1 178 ? 6.27372   0.14914   44.47331 1.000 21.92019 ? 172 ALA A CA  1 
ATOM   1381 C C   . ALA A 1 178 ? 7.68689   -0.26123  44.08654 1.000 23.24014 ? 172 ALA A C   1 
ATOM   1382 O O   . ALA A 1 178 ? 7.89297   -1.11651  43.21471 1.000 23.85999 ? 172 ALA A O   1 
ATOM   1383 C CB  . ALA A 1 178 ? 5.71404   -0.79877  45.52616 1.000 21.81556 ? 172 ALA A CB  1 
ATOM   1384 N N   . ASP A 1 179 ? 8.67194   0.38041   44.70967 1.000 23.59586 ? 173 ASP A N   1 
ATOM   1385 C CA  . ASP A 1 179 ? 10.07513  0.15880   44.36936 1.000 27.14349 ? 173 ASP A CA  1 
ATOM   1386 C C   . ASP A 1 179 ? 10.91647  0.36426   45.61742 1.000 26.65084 ? 173 ASP A C   1 
ATOM   1387 O O   . ASP A 1 179 ? 11.70053  1.31376   45.71265 1.000 26.32584 ? 173 ASP A O   1 
ATOM   1388 C CB  . ASP A 1 179 ? 10.49789  1.10389   43.25187 1.000 29.72455 ? 173 ASP A CB  1 
ATOM   1389 C CG  . ASP A 1 179 ? 11.86796  0.78144   42.70057 1.000 33.78212 ? 173 ASP A CG  1 
ATOM   1390 O OD1 . ASP A 1 179 ? 12.46741  -0.23945  43.10574 1.000 35.46827 ? 173 ASP A OD1 1 
ATOM   1391 O OD2 . ASP A 1 179 ? 12.33441  1.56374   41.86707 1.000 34.97375 ? 173 ASP A OD2 1 
ATOM   1392 N N   . PRO A 1 180 ? 10.78368  -0.52508  46.59904 1.000 28.42754 ? 174 PRO A N   1 
ATOM   1393 C CA  . PRO A 1 180 ? 11.41734  -0.26802  47.89810 1.000 30.80284 ? 174 PRO A CA  1 
ATOM   1394 C C   . PRO A 1 180 ? 12.92921  -0.29568  47.85582 1.000 32.01629 ? 174 PRO A C   1 
ATOM   1395 O O   . PRO A 1 180 ? 13.56117  0.37343   48.68745 1.000 33.13261 ? 174 PRO A O   1 
ATOM   1396 C CB  . PRO A 1 180 ? 10.84479  -1.37239  48.79610 1.000 32.72169 ? 174 PRO A CB  1 
ATOM   1397 C CG  . PRO A 1 180 ? 10.34701  -2.42977  47.85429 1.000 32.07021 ? 174 PRO A CG  1 
ATOM   1398 C CD  . PRO A 1 180 ? 9.90030   -1.70784  46.63012 1.000 29.89961 ? 174 PRO A CD  1 
ATOM   1399 N N   . ASP A 1 181 ? 13.52934  -1.02047  46.90932 1.000 32.58408 ? 175 ASP A N   1 
ATOM   1400 C CA  . ASP A 1 181 ? 14.98299  -1.05999  46.84242 1.000 34.08088 ? 175 ASP A CA  1 
ATOM   1401 C C   . ASP A 1 181 ? 15.57627  0.24088   46.33389 1.000 33.59450 ? 175 ASP A C   1 
ATOM   1402 O O   . ASP A 1 181 ? 16.78918  0.43495   46.46433 1.000 34.73421 ? 175 ASP A O   1 
ATOM   1403 C CB  . ASP A 1 181 ? 15.48537  -2.20424  45.94228 0.815 36.28067 ? 175 ASP A CB  1 
ATOM   1404 C CG  . ASP A 1 181 ? 14.98904  -3.55372  46.38524 0.774 38.57940 ? 175 ASP A CG  1 
ATOM   1405 O OD1 . ASP A 1 181 ? 14.76588  -3.73208  47.60327 0.669 39.56850 ? 175 ASP A OD1 1 
ATOM   1406 O OD2 . ASP A 1 181 ? 14.89247  -4.45170  45.53238 0.403 39.08413 ? 175 ASP A OD2 1 
ATOM   1407 N N   . HIS A 1 182 ? 14.77146  1.11459   45.73455 1.000 32.38509 ? 176 HIS A N   1 
ATOM   1408 C CA  . HIS A 1 182 ? 15.25797  2.38540   45.22439 1.000 32.10650 ? 176 HIS A CA  1 
ATOM   1409 C C   . HIS A 1 182 ? 14.60632  3.56401   45.94338 1.000 30.85547 ? 176 HIS A C   1 
ATOM   1410 O O   . HIS A 1 182 ? 14.45397  4.63986   45.36530 1.000 34.06563 ? 176 HIS A O   1 
ATOM   1411 C CB  . HIS A 1 182 ? 15.03476  2.48426   43.71991 1.000 34.02862 ? 176 HIS A CB  1 
ATOM   1412 C CG  . HIS A 1 182 ? 15.73667  1.41982   42.95088 0.993 35.06482 ? 176 HIS A CG  1 
ATOM   1413 N ND1 . HIS A 1 182 ? 15.23610  0.13900   42.82442 0.651 35.54776 ? 176 HIS A ND1 1 
ATOM   1414 C CD2 . HIS A 1 182 ? 16.97180  1.39535   42.39445 0.778 34.97521 ? 176 HIS A CD2 1 
ATOM   1415 C CE1 . HIS A 1 182 ? 16.09248  -0.59789  42.13707 0.423 36.24228 ? 176 HIS A CE1 1 
ATOM   1416 N NE2 . HIS A 1 182 ? 17.15656  0.13713   41.87352 0.746 36.19048 ? 176 HIS A NE2 1 
ATOM   1417 N N   . ASP A 1 183 ? 14.24035  3.38397   47.21303 1.000 25.99774 ? 177 ASP A N   1 
ATOM   1418 C CA  . ASP A 1 183 ? 13.49547  4.40520   47.94239 1.000 24.89489 ? 177 ASP A CA  1 
ATOM   1419 C C   . ASP A 1 183 ? 14.37160  5.48694   48.56333 1.000 24.74140 ? 177 ASP A C   1 
ATOM   1420 O O   . ASP A 1 183 ? 13.85521  6.55337   48.89374 1.000 24.09130 ? 177 ASP A O   1 
ATOM   1421 C CB  . ASP A 1 183 ? 12.67301  3.74382   49.05082 1.000 24.83799 ? 177 ASP A CB  1 
ATOM   1422 C CG  . ASP A 1 183 ? 11.77499  4.70516   49.75787 1.000 25.66972 ? 177 ASP A CG  1 
ATOM   1423 O OD1 . ASP A 1 183 ? 10.82422  5.15085   49.11232 1.000 25.89275 ? 177 ASP A OD1 1 
ATOM   1424 O OD2 . ASP A 1 183 ? 11.98535  5.01208   50.94657 1.000 27.37151 ? 177 ASP A OD2 1 
ATOM   1425 N N   . HIS A 1 184 ? 15.68050  5.24977   48.72513 1.000 24.68079 ? 178 HIS A N   1 
ATOM   1426 C CA  . HIS A 1 184 ? 16.50496  6.13551   49.54177 1.000 23.63969 ? 178 HIS A CA  1 
ATOM   1427 C C   . HIS A 1 184 ? 16.89360  7.35680   48.72104 1.000 24.23310 ? 178 HIS A C   1 
ATOM   1428 O O   . HIS A 1 184 ? 17.23898  7.25317   47.53341 1.000 24.37787 ? 178 HIS A O   1 
ATOM   1429 C CB  . HIS A 1 184 ? 17.79092  5.43754   50.00221 1.000 25.84803 ? 178 HIS A CB  1 
ATOM   1430 C CG  . HIS A 1 184 ? 17.63380  4.57447   51.21795 0.422 28.37952 ? 178 HIS A CG  1 
ATOM   1431 N ND1 . HIS A 1 184 ? 17.66203  3.19611   51.14568 0.404 30.15833 ? 178 HIS A ND1 1 
ATOM   1432 C CD2 . HIS A 1 184 ? 17.47819  4.87850   52.53035 0.421 29.33048 ? 178 HIS A CD2 1 
ATOM   1433 C CE1 . HIS A 1 184 ? 17.51226  2.68780   52.35798 0.588 31.30879 ? 178 HIS A CE1 1 
ATOM   1434 N NE2 . HIS A 1 184 ? 17.39427  3.68737   53.21493 0.430 30.92822 ? 178 HIS A NE2 1 
ATOM   1435 N N   . THR A 1 185 ? 16.89281  8.50377   49.37460 1.000 24.06356 ? 179 THR A N   1 
ATOM   1436 C CA  . THR A 1 185 ? 17.32038  9.74502   48.76625 1.000 23.71436 ? 179 THR A CA  1 
ATOM   1437 C C   . THR A 1 185 ? 17.88554  10.62433  49.86964 1.000 24.05069 ? 179 THR A C   1 
ATOM   1438 O O   . THR A 1 185 ? 17.96021  10.22558  51.04230 1.000 23.71714 ? 179 THR A O   1 
ATOM   1439 C CB  . THR A 1 185 ? 16.15521  10.40215  48.01744 1.000 24.40504 ? 179 THR A CB  1 
ATOM   1440 O OG1 . THR A 1 185 ? 16.62724  11.50584  47.24604 1.000 25.09179 ? 179 THR A OG1 1 
ATOM   1441 C CG2 . THR A 1 185 ? 15.05455  10.89336  48.97451 1.000 24.66743 ? 179 THR A CG2 1 
ATOM   1442 N N   . GLY A 1 186 ? 18.33090  11.80365  49.47652 1.000 24.00640 ? 180 GLY A N   1 
ATOM   1443 C CA  . GLY A 1 186 ? 18.92748  12.73495  50.40234 1.000 23.42712 ? 180 GLY A CA  1 
ATOM   1444 C C   . GLY A 1 186 ? 17.88543  13.55806  51.13270 1.000 23.45323 ? 180 GLY A C   1 
ATOM   1445 O O   . GLY A 1 186 ? 16.67404  13.45681  50.91899 1.000 24.60429 ? 180 GLY A O   1 
ATOM   1446 N N   . PHE A 1 187 ? 18.39757  14.37158  52.03711 1.000 23.73743 ? 181 PHE A N   1 
ATOM   1447 C CA  . PHE A 1 187 ? 17.61431  15.21781  52.92810 1.000 22.05243 ? 181 PHE A CA  1 
ATOM   1448 C C   . PHE A 1 187 ? 17.04413  16.39968  52.14784 1.000 22.81604 ? 181 PHE A C   1 
ATOM   1449 O O   . PHE A 1 187 ? 17.73789  17.00359  51.31891 1.000 26.10193 ? 181 PHE A O   1 
ATOM   1450 C CB  . PHE A 1 187 ? 18.56391  15.67936  54.04338 1.000 20.24315 ? 181 PHE A CB  1 
ATOM   1451 C CG  . PHE A 1 187 ? 17.96952  16.63713  55.06639 1.000 21.27394 ? 181 PHE A CG  1 
ATOM   1452 C CD1 . PHE A 1 187 ? 16.79091  16.35863  55.71290 1.000 20.44788 ? 181 PHE A CD1 1 
ATOM   1453 C CD2 . PHE A 1 187 ? 18.66681  17.80650  55.41867 1.000 22.70788 ? 181 PHE A CD2 1 
ATOM   1454 C CE1 . PHE A 1 187 ? 16.28810  17.25971  56.70833 1.000 21.72899 ? 181 PHE A CE1 1 
ATOM   1455 C CE2 . PHE A 1 187 ? 18.17436  18.68725  56.39416 1.000 21.86280 ? 181 PHE A CE2 1 
ATOM   1456 C CZ  . PHE A 1 187 ? 16.97274  18.42185  57.02490 1.000 21.55185 ? 181 PHE A CZ  1 
ATOM   1457 N N   . LEU A 1 188 ? 15.76433  16.70574  52.39805 1.000 24.13431 ? 182 LEU A N   1 
ATOM   1458 C CA  . LEU A 1 188 ? 15.07326  17.84854  51.78053 1.000 26.30118 ? 182 LEU A CA  1 
ATOM   1459 C C   . LEU A 1 188 ? 14.90743  17.64278  50.27752 1.000 26.95109 ? 182 LEU A C   1 
ATOM   1460 O O   . LEU A 1 188 ? 14.99703  18.59356  49.48963 1.000 29.83985 ? 182 LEU A O   1 
ATOM   1461 C CB  . LEU A 1 188 ? 15.81034  19.16756  52.07176 1.000 30.05879 ? 182 LEU A CB  1 
ATOM   1462 C CG  . LEU A 1 188 ? 16.03592  19.45956  53.56358 1.000 32.85017 ? 182 LEU A CG  1 
ATOM   1463 C CD1 . LEU A 1 188 ? 16.71927  20.82043  53.79516 1.000 34.57919 ? 182 LEU A CD1 1 
ATOM   1464 C CD2 . LEU A 1 188 ? 14.76821  19.35708  54.35772 1.000 32.17808 ? 182 LEU A CD2 1 
ATOM   1465 N N   . THR A 1 189 ? 14.67587  16.39625  49.87048 1.000 25.60742 ? 183 THR A N   1 
ATOM   1466 C CA  . THR A 1 189 ? 14.40128  16.09509  48.46654 1.000 27.53681 ? 183 THR A CA  1 
ATOM   1467 C C   . THR A 1 189 ? 12.96382  16.46309  48.12750 1.000 26.86196 ? 183 THR A C   1 
ATOM   1468 O O   . THR A 1 189 ? 12.00676  16.06301  48.83013 1.000 27.33294 ? 183 THR A O   1 
ATOM   1469 C CB  . THR A 1 189 ? 14.61425  14.60729  48.17322 1.000 28.79947 ? 183 THR A CB  1 
ATOM   1470 O OG1 . THR A 1 189 ? 15.97308  14.27704  48.38813 1.000 28.19267 ? 183 THR A OG1 1 
ATOM   1471 C CG2 . THR A 1 189 ? 14.24853  14.24517  46.71846 1.000 28.47618 ? 183 THR A CG2 1 
ATOM   1472 N N   . GLU A 1 190 ? 12.82933  17.18634  47.02168 1.000 27.12595 ? 184 GLU A N   1 
ATOM   1473 C CA  . GLU A 1 190 ? 11.55642  17.69196  46.55457 1.000 30.36912 ? 184 GLU A CA  1 
ATOM   1474 C C   . GLU A 1 190 ? 10.54641  16.55850  46.38719 1.000 32.95817 ? 184 GLU A C   1 
ATOM   1475 O O   . GLU A 1 190 ? 10.90469  15.42444  46.04934 1.000 34.83970 ? 184 GLU A O   1 
ATOM   1476 C CB  . GLU A 1 190 ? 11.81160  18.40429  45.22990 1.000 32.67887 ? 184 GLU A CB  1 
ATOM   1477 C CG  . GLU A 1 190 ? 12.71421  19.63964  45.39115 0.556 33.45710 ? 184 GLU A CG  1 
ATOM   1478 C CD  . GLU A 1 190 ? 14.24316  19.35234  45.38104 0.286 35.31389 ? 184 GLU A CD  1 
ATOM   1479 O OE1 . GLU A 1 190 ? 14.70336  18.18044  45.31103 0.538 36.46108 ? 184 GLU A OE1 1 
ATOM   1480 O OE2 . GLU A 1 190 ? 15.00336  20.34249  45.41997 0.175 35.85231 ? 184 GLU A OE2 1 
ATOM   1481 N N   . TYR A 1 191 ? 9.27124   16.85756  46.63593 1.000 33.83278 ? 185 TYR A N   1 
ATOM   1482 C CA  . TYR A 1 191 ? 8.22280   15.85248  46.58810 1.000 32.82076 ? 185 TYR A CA  1 
ATOM   1483 C C   . TYR A 1 191 ? 6.93976   16.47998  46.05564 1.000 34.55521 ? 185 TYR A C   1 
ATOM   1484 O O   . TYR A 1 191 ? 6.69802   17.66925  46.27293 1.000 36.99967 ? 185 TYR A O   1 
ATOM   1485 C CB  . TYR A 1 191 ? 7.90404   15.31019  47.93929 1.000 33.15621 ? 185 TYR A CB  1 
ATOM   1486 C CG  . TYR A 1 191 ? 7.21295   13.94336  47.89789 1.000 32.51456 ? 185 TYR A CG  1 
ATOM   1487 C CD1 . TYR A 1 191 ? 7.84236   12.82377  47.32485 1.000 31.98921 ? 185 TYR A CD1 1 
ATOM   1488 C CD2 . TYR A 1 191 ? 5.96260   13.78346  48.42431 1.000 32.41954 ? 185 TYR A CD2 1 
ATOM   1489 C CE1 . TYR A 1 191 ? 7.23781   11.59588  47.29433 1.000 29.56046 ? 185 TYR A CE1 1 
ATOM   1490 C CE2 . TYR A 1 191 ? 5.33754   12.54376  48.39551 1.000 32.68074 ? 185 TYR A CE2 1 
ATOM   1491 C CZ  . TYR A 1 191 ? 5.98028   11.45796  47.85928 1.000 30.55106 ? 185 TYR A CZ  1 
ATOM   1492 O OH  . TYR A 1 191 ? 5.32219   10.25449  47.87050 1.000 32.60475 ? 185 TYR A OH  1 
ATOM   1493 N N   . VAL A 1 192 ? 6.09729   15.68150  45.39717 1.000 33.91458 ? 186 VAL A N   1 
ATOM   1494 C CA  . VAL A 1 192 ? 4.93622   16.23171  44.68690 1.000 34.34812 ? 186 VAL A CA  1 
ATOM   1495 C C   . VAL A 1 192 ? 3.61918   16.09712  45.46759 1.000 33.55998 ? 186 VAL A C   1 
ATOM   1496 O O   . VAL A 1 192 ? 2.77203   16.99019  45.41233 1.000 36.37568 ? 186 VAL A O   1 
ATOM   1497 C CB  . VAL A 1 192 ? 4.81581   15.61292  43.27911 1.000 37.19607 ? 186 VAL A CB  1 
ATOM   1498 C CG1 . VAL A 1 192 ? 3.60923   16.23158  42.55695 1.000 38.41832 ? 186 VAL A CG1 1 
ATOM   1499 C CG2 . VAL A 1 192 ? 6.06905   15.85928  42.49941 1.000 37.80003 ? 186 VAL A CG2 1 
ATOM   1500 N N   . ALA A 1 193 ? 3.38313   15.00086  46.16739 1.000 30.20378 ? 187 ALA A N   1 
ATOM   1501 C CA  . ALA A 1 193 ? 2.09088   14.73320  46.80352 1.000 27.90283 ? 187 ALA A CA  1 
ATOM   1502 C C   . ALA A 1 193 ? 1.75705   15.74488  47.90904 1.000 25.91729 ? 187 ALA A C   1 
ATOM   1503 O O   . ALA A 1 193 ? 2.62782   16.36456  48.45655 1.000 27.40091 ? 187 ALA A O   1 
ATOM   1504 C CB  . ALA A 1 193 ? 2.11959   13.35059  47.44263 1.000 27.40000 ? 187 ALA A CB  1 
ATOM   1505 N N   . THR A 1 194 ? 0.46806   15.78464  48.32110 1.000 25.66305 ? 188 THR A N   1 
ATOM   1506 C CA  . THR A 1 194 ? -0.06597  16.84534  49.20368 1.000 22.30834 ? 188 THR A CA  1 
ATOM   1507 C C   . THR A 1 194 ? 0.58722   16.94091  50.59086 1.000 22.88982 ? 188 THR A C   1 
ATOM   1508 O O   . THR A 1 194 ? 0.62435   15.96775  51.35330 1.000 25.18224 ? 188 THR A O   1 
ATOM   1509 C CB  . THR A 1 194 ? -1.57481  16.63282  49.33685 1.000 19.88712 ? 188 THR A CB  1 
ATOM   1510 O OG1 . THR A 1 194 ? -2.09539  16.40404  48.01598 1.000 19.94679 ? 188 THR A OG1 1 
ATOM   1511 C CG2 . THR A 1 194 ? -2.25605  17.80430  49.96519 1.000 20.42796 ? 188 THR A CG2 1 
ATOM   1512 N N   . ARG A 1 195 ? 0.99923   18.16286  50.95659 1.000 21.42447 ? 189 ARG A N   1 
ATOM   1513 C CA  . ARG A 1 195 ? 1.94886   18.31921  52.05155 1.000 22.11869 ? 189 ARG A CA  1 
ATOM   1514 C C   . ARG A 1 195 ? 1.41204   17.78243  53.37982 1.000 20.65580 ? 189 ARG A C   1 
ATOM   1515 O O   . ARG A 1 195 ? 2.13020   17.08328  54.08732 1.000 21.14770 ? 189 ARG A O   1 
ATOM   1516 C CB  . ARG A 1 195 ? 2.40591   19.77445  52.13595 1.000 25.44742 ? 189 ARG A CB  1 
ATOM   1517 C CG  . ARG A 1 195 ? 3.38259   20.06296  53.27818 1.000 26.48004 ? 189 ARG A CG  1 
ATOM   1518 C CD  . ARG A 1 195 ? 3.36904   21.50196  53.77153 1.000 29.80344 ? 189 ARG A CD  1 
ATOM   1519 N NE  . ARG A 1 195 ? 3.58213   22.33532  52.60025 0.893 32.54678 ? 189 ARG A NE  1 
ATOM   1520 C CZ  . ARG A 1 195 ? 2.74233   23.26218  52.16813 0.848 33.89365 ? 189 ARG A CZ  1 
ATOM   1521 N NH1 . ARG A 1 195 ? 1.67994   23.61499  52.87540 0.907 33.18540 ? 189 ARG A NH1 1 
ATOM   1522 N NH2 . ARG A 1 195 ? 2.96819   23.83530  50.98260 0.674 34.96885 ? 189 ARG A NH2 1 
ATOM   1523 N N   . TRP A 1 196 ? 0.15872   18.05818  53.72101 1.000 20.91476 ? 190 TRP A N   1 
ATOM   1524 C CA  . TRP A 1 196 ? -0.34263  17.69640  55.05646 1.000 21.44542 ? 190 TRP A CA  1 
ATOM   1525 C C   . TRP A 1 196 ? -0.40525  16.19882  55.28646 1.000 18.97984 ? 190 TRP A C   1 
ATOM   1526 O O   . TRP A 1 196 ? -0.46808  15.76336  56.44729 1.000 19.80337 ? 190 TRP A O   1 
ATOM   1527 C CB  . TRP A 1 196 ? -1.75579  18.25481  55.29653 1.000 21.23118 ? 190 TRP A CB  1 
ATOM   1528 C CG  . TRP A 1 196 ? -1.82687  19.73678  55.34521 1.000 22.13911 ? 190 TRP A CG  1 
ATOM   1529 C CD1 . TRP A 1 196 ? -0.78393  20.60865  55.42338 1.000 24.12530 ? 190 TRP A CD1 1 
ATOM   1530 C CD2 . TRP A 1 196 ? -3.00632  20.50137  55.26940 1.000 24.61041 ? 190 TRP A CD2 1 
ATOM   1531 N NE1 . TRP A 1 196 ? -1.25151  21.89787  55.41039 1.000 25.73742 ? 190 TRP A NE1 1 
ATOM   1532 C CE2 . TRP A 1 196 ? -2.63049  21.86208  55.32653 1.000 25.45564 ? 190 TRP A CE2 1 
ATOM   1533 C CE3 . TRP A 1 196 ? -4.36404  20.16288  55.14760 1.000 23.82752 ? 190 TRP A CE3 1 
ATOM   1534 C CZ2 . TRP A 1 196 ? -3.57882  22.91313  55.25533 1.000 26.12810 ? 190 TRP A CZ2 1 
ATOM   1535 C CZ3 . TRP A 1 196 ? -5.29432  21.17885  55.11152 1.000 26.05642 ? 190 TRP A CZ3 1 
ATOM   1536 C CH2 . TRP A 1 196 ? -4.89912  22.54642  55.15765 1.000 26.64065 ? 190 TRP A CH2 1 
ATOM   1537 N N   . TYR A 1 197 ? -0.37356  15.39284  54.23039 1.000 17.20263 ? 191 TYR A N   1 
ATOM   1538 C CA  . TYR A 1 197 ? -0.51795  13.94458  54.34371 1.000 16.63181 ? 191 TYR A CA  1 
ATOM   1539 C C   . TYR A 1 197 ? 0.79740   13.22322  54.03643 1.000 17.57626 ? 191 TYR A C   1 
ATOM   1540 O O   . TYR A 1 197 ? 0.79682   12.01255  53.90633 1.000 16.40190 ? 191 TYR A O   1 
ATOM   1541 C CB  . TYR A 1 197 ? -1.66906  13.46869  53.42476 1.000 17.38900 ? 191 TYR A CB  1 
ATOM   1542 C CG  . TYR A 1 197 ? -2.92439  14.26389  53.74582 1.000 18.73456 ? 191 TYR A CG  1 
ATOM   1543 C CD1 . TYR A 1 197 ? -3.75690  13.85599  54.80029 1.000 19.61146 ? 191 TYR A CD1 1 
ATOM   1544 C CD2 . TYR A 1 197 ? -3.24168  15.46002  53.05557 1.000 18.03812 ? 191 TYR A CD2 1 
ATOM   1545 C CE1 . TYR A 1 197 ? -4.84494  14.62236  55.17934 1.000 17.73359 ? 191 TYR A CE1 1 
ATOM   1546 C CE2 . TYR A 1 197 ? -4.34462  16.20387  53.40080 1.000 19.87442 ? 191 TYR A CE2 1 
ATOM   1547 C CZ  . TYR A 1 197 ? -5.14047  15.80183  54.47932 1.000 18.84620 ? 191 TYR A CZ  1 
ATOM   1548 O OH  . TYR A 1 197 ? -6.22784  16.56555  54.85249 1.000 20.30968 ? 191 TYR A OH  1 
ATOM   1549 N N   . ARG A 1 198 ? 1.91737   13.95723  53.96228 1.000 17.53939 ? 192 ARG A N   1 
ATOM   1550 C CA  . ARG A 1 198 ? 3.25440   13.40443  53.71638 1.000 18.37237 ? 192 ARG A CA  1 
ATOM   1551 C C   . ARG A 1 198 ? 3.86101   12.81027  54.96349 1.000 16.67140 ? 192 ARG A C   1 
ATOM   1552 O O   . ARG A 1 198 ? 3.97408   13.48905  55.99094 1.000 18.07925 ? 192 ARG A O   1 
ATOM   1553 C CB  . ARG A 1 198 ? 4.23243   14.48928  53.25518 1.000 21.76971 ? 192 ARG A CB  1 
ATOM   1554 C CG  . ARG A 1 198 ? 4.14403   14.88729  51.89251 1.000 22.70680 ? 192 ARG A CG  1 
ATOM   1555 C CD  . ARG A 1 198 ? 5.14024   16.01701  51.61497 1.000 19.10457 ? 192 ARG A CD  1 
ATOM   1556 N NE  . ARG A 1 198 ? 4.69509   16.68441  50.41162 1.000 20.22630 ? 192 ARG A NE  1 
ATOM   1557 C CZ  . ARG A 1 198 ? 5.01772   17.92295  50.08554 1.000 24.95514 ? 192 ARG A CZ  1 
ATOM   1558 N NH1 . ARG A 1 198 ? 5.92502   18.60860  50.77528 1.000 26.77989 ? 192 ARG A NH1 1 
ATOM   1559 N NH2 . ARG A 1 198 ? 4.48761   18.46355  48.98852 1.000 28.67262 ? 192 ARG A NH2 1 
ATOM   1560 N N   . ALA A 1 199 ? 4.36302   11.59323  54.81752 1.000 15.68633 ? 193 ALA A N   1 
ATOM   1561 C CA  . ALA A 1 199 ? 5.06408   10.89310  55.88369 1.000 14.78908 ? 193 ALA A CA  1 
ATOM   1562 C C   . ALA A 1 199 ? 6.38495   11.61598  56.21804 1.000 16.70093 ? 193 ALA A C   1 
ATOM   1563 O O   . ALA A 1 199 ? 7.00542   12.24629  55.35190 1.000 17.29173 ? 193 ALA A O   1 
ATOM   1564 C CB  . ALA A 1 199 ? 5.34315   9.44322   55.44037 1.000 15.27179 ? 193 ALA A CB  1 
ATOM   1565 N N   . PRO A 1 200 ? 6.82253   11.54926  57.47646 1.000 16.83970 ? 194 PRO A N   1 
ATOM   1566 C CA  . PRO A 1 200 ? 8.01783   12.29585  57.86792 1.000 17.10624 ? 194 PRO A CA  1 
ATOM   1567 C C   . PRO A 1 200 ? 9.24117   11.91231  57.04787 1.000 17.18168 ? 194 PRO A C   1 
ATOM   1568 O O   . PRO A 1 200 ? 10.09135  12.78211  56.76603 1.000 18.11211 ? 194 PRO A O   1 
ATOM   1569 C CB  . PRO A 1 200 ? 8.16743   11.92995  59.36375 1.000 16.93574 ? 194 PRO A CB  1 
ATOM   1570 C CG  . PRO A 1 200 ? 7.44170   10.64130  59.54988 1.000 17.19690 ? 194 PRO A CG  1 
ATOM   1571 C CD  . PRO A 1 200 ? 6.27577   10.72931  58.59009 1.000 16.29070 ? 194 PRO A CD  1 
ATOM   1572 N N   . GLU A 1 201 ? 9.34173   10.63803  56.62760 1.000 17.78568 ? 195 GLU A N   1 
ATOM   1573 C CA  . GLU A 1 201 ? 10.55410  10.21949  55.91190 1.000 18.12411 ? 195 GLU A CA  1 
ATOM   1574 C C   . GLU A 1 201 ? 10.67354  10.89959  54.55253 1.000 18.25270 ? 195 GLU A C   1 
ATOM   1575 O O   . GLU A 1 201 ? 11.77952  10.95428  53.99211 1.000 18.74979 ? 195 GLU A O   1 
ATOM   1576 C CB  . GLU A 1 201 ? 10.60600  8.69034   55.76473 1.000 17.58197 ? 195 GLU A CB  1 
ATOM   1577 C CG  . GLU A 1 201 ? 9.44028   8.05946   54.96289 1.000 17.51690 ? 195 GLU A CG  1 
ATOM   1578 C CD  . GLU A 1 201 ? 8.23358   7.69041   55.84225 1.000 18.55956 ? 195 GLU A CD  1 
ATOM   1579 O OE1 . GLU A 1 201 ? 8.15260   8.14823   57.00964 1.000 19.30035 ? 195 GLU A OE1 1 
ATOM   1580 O OE2 . GLU A 1 201 ? 7.40537   6.89993   55.36349 1.000 18.61072 ? 195 GLU A OE2 1 
ATOM   1581 N N   . ILE A 1 202 ? 9.56724   11.41473  54.00181 1.000 18.24399 ? 196 ILE A N   1 
ATOM   1582 C CA  . ILE A 1 202 ? 9.64878   12.10386  52.70662 1.000 17.56142 ? 196 ILE A CA  1 
ATOM   1583 C C   . ILE A 1 202 ? 10.61887  13.27613  52.79073 1.000 19.95622 ? 196 ILE A C   1 
ATOM   1584 O O   . ILE A 1 202 ? 11.36504  13.55651  51.85153 1.000 20.81736 ? 196 ILE A O   1 
ATOM   1585 C CB  . ILE A 1 202 ? 8.25806   12.58296  52.26235 1.000 18.96120 ? 196 ILE A CB  1 
ATOM   1586 C CG1 . ILE A 1 202 ? 7.39513   11.40282  51.83468 1.000 19.68726 ? 196 ILE A CG1 1 
ATOM   1587 C CG2 . ILE A 1 202 ? 8.36106   13.60821  51.09669 1.000 20.69910 ? 196 ILE A CG2 1 
ATOM   1588 C CD1 . ILE A 1 202 ? 7.97305   10.56886  50.72654 1.000 21.08817 ? 196 ILE A CD1 1 
ATOM   1589 N N   . MET A 1 203 ? 10.59795  14.00184  53.90543 1.000 20.27097 ? 197 MET A N   1 
ATOM   1590 C CA  . MET A 1 203 ? 11.48610  15.13254  54.16001 1.000 20.24733 ? 197 MET A CA  1 
ATOM   1591 C C   . MET A 1 203 ? 12.88214  14.72383  54.57915 1.000 20.37853 ? 197 MET A C   1 
ATOM   1592 O O   . MET A 1 203 ? 13.76821  15.57721  54.60585 1.000 23.60215 ? 197 MET A O   1 
ATOM   1593 C CB  . MET A 1 203 ? 10.85260  16.05664  55.22096 1.000 21.72889 ? 197 MET A CB  1 
ATOM   1594 C CG  . MET A 1 203 ? 9.57407   16.78052  54.71244 1.000 23.09228 ? 197 MET A CG  1 
ATOM   1595 S SD  . MET A 1 203 ? 8.08979   15.78944  54.57248 1.000 23.05425 ? 197 MET A SD  1 
ATOM   1596 C CE  . MET A 1 203 ? 7.52847   15.64885  56.29081 1.000 22.75649 ? 197 MET A CE  1 
ATOM   1597 N N   . LEU A 1 204 ? 13.08487  13.46632  54.92733 1.000 19.56118 ? 198 LEU A N   1 
ATOM   1598 C CA  . LEU A 1 204 ? 14.33465  13.01055  55.49146 1.000 18.90908 ? 198 LEU A CA  1 
ATOM   1599 C C   . LEU A 1 204 ? 15.14167  12.19025  54.49835 1.000 20.52440 ? 198 LEU A C   1 
ATOM   1600 O O   . LEU A 1 204 ? 16.31036  12.53277  54.25659 1.000 21.76475 ? 198 LEU A O   1 
ATOM   1601 C CB  . LEU A 1 204 ? 14.06280  12.19970  56.75759 1.000 20.71456 ? 198 LEU A CB  1 
ATOM   1602 C CG  . LEU A 1 204 ? 13.47369  13.03858  57.90833 1.000 19.58868 ? 198 LEU A CG  1 
ATOM   1603 C CD1 . LEU A 1 204 ? 12.92675  12.10768  58.98089 1.000 20.54782 ? 198 LEU A CD1 1 
ATOM   1604 C CD2 . LEU A 1 204 ? 14.60044  13.92549  58.48690 1.000 20.46727 ? 198 LEU A CD2 1 
ATOM   1605 N N   . ASN A 1 205 ? 14.57579  11.10874  53.94878 1.000 20.21178 ? 199 ASN A N   1 
ATOM   1606 C CA  . ASN A 1 205 ? 15.42335  10.20329  53.16012 1.000 21.97615 ? 199 ASN A CA  1 
ATOM   1607 C C   . ASN A 1 205 ? 14.61580  9.29997   52.22270 1.000 20.92893 ? 199 ASN A C   1 
ATOM   1608 O O   . ASN A 1 205 ? 15.14098  8.25765   51.81920 1.000 21.45703 ? 199 ASN A O   1 
ATOM   1609 C CB  . ASN A 1 205 ? 16.25989  9.32007   54.11041 1.000 22.21286 ? 199 ASN A CB  1 
ATOM   1610 C CG  . ASN A 1 205 ? 15.40442  8.39431   54.94310 0.993 23.62664 ? 199 ASN A CG  1 
ATOM   1611 O OD1 . ASN A 1 205 ? 14.20314  8.54439   54.98265 0.973 24.52991 ? 199 ASN A OD1 1 
ATOM   1612 N ND2 . ASN A 1 205 ? 16.04221  7.46384   55.66946 0.914 23.88851 ? 199 ASN A ND2 1 
ATOM   1613 N N   . SER A 1 206 ? 13.36072  9.62247   51.88059 1.000 20.03205 ? 200 SER A N   1 
ATOM   1614 C CA  . SER A 1 206 ? 12.52652  8.69339   51.13224 1.000 19.94405 ? 200 SER A CA  1 
ATOM   1615 C C   . SER A 1 206 ? 11.92835  9.36231   49.91028 1.000 20.18649 ? 200 SER A C   1 
ATOM   1616 O O   . SER A 1 206 ? 11.44722  10.50550  49.99765 1.000 21.87322 ? 200 SER A O   1 
ATOM   1617 C CB  . SER A 1 206 ? 11.38882  8.18541   52.00764 1.000 21.28677 ? 200 SER A CB  1 
ATOM   1618 O OG  . SER A 1 206 ? 10.50247  7.32507   51.29646 1.000 21.79828 ? 200 SER A OG  1 
ATOM   1619 N N   . LYS A 1 207 ? 11.90352  8.62007   48.78682 1.000 19.55279 ? 201 LYS A N   1 
ATOM   1620 C CA  . LYS A 1 207 ? 11.23843  9.01397   47.54799 1.000 22.14618 ? 201 LYS A CA  1 
ATOM   1621 C C   . LYS A 1 207 ? 9.75039   8.65469   47.53791 1.000 21.64975 ? 201 LYS A C   1 
ATOM   1622 O O   . LYS A 1 207 ? 9.07100   8.93355   46.54762 1.000 22.76477 ? 201 LYS A O   1 
ATOM   1623 C CB  . LYS A 1 207 ? 11.94352  8.32792   46.36377 1.000 22.86109 ? 201 LYS A CB  1 
ATOM   1624 C CG  . LYS A 1 207 ? 13.42722  8.68259   46.22946 1.000 26.69744 ? 201 LYS A CG  1 
ATOM   1625 C CD  . LYS A 1 207 ? 13.93005  8.22341   44.85004 0.782 28.61071 ? 201 LYS A CD  1 
ATOM   1626 C CE  . LYS A 1 207 ? 15.45920  8.18902   44.75944 0.458 30.76925 ? 201 LYS A CE  1 
ATOM   1627 N NZ  . LYS A 1 207 ? 15.92512  7.45077   43.55913 0.601 33.47257 ? 201 LYS A NZ  1 
ATOM   1628 N N   . GLY A 1 208 ? 9.22630   8.01700   48.58668 1.000 20.44368 ? 202 GLY A N   1 
ATOM   1629 C CA  . GLY A 1 208 ? 7.80370   7.69279   48.60364 1.000 21.68326 ? 202 GLY A CA  1 
ATOM   1630 C C   . GLY A 1 208 ? 7.50175   6.50301   47.72081 1.000 21.54695 ? 202 GLY A C   1 
ATOM   1631 O O   . GLY A 1 208 ? 6.42556   6.43310   47.08516 1.000 23.58122 ? 202 GLY A O   1 
ATOM   1632 N N   . TYR A 1 209 ? 8.44321   5.56529   47.63536 1.000 21.31123 ? 203 TYR A N   1 
ATOM   1633 C CA  . TYR A 1 209 ? 8.26946   4.43248   46.74398 1.000 20.52405 ? 203 TYR A CA  1 
ATOM   1634 C C   . TYR A 1 209 ? 7.94384   3.15613   47.49516 1.000 22.21983 ? 203 TYR A C   1 
ATOM   1635 O O   . TYR A 1 209 ? 8.08722   2.05698   46.93021 1.000 23.00190 ? 203 TYR A O   1 
ATOM   1636 C CB  . TYR A 1 209 ? 9.54611   4.17631   45.92226 1.000 22.46362 ? 203 TYR A CB  1 
ATOM   1637 C CG  . TYR A 1 209 ? 9.89446   5.12275   44.82718 1.000 26.76611 ? 203 TYR A CG  1 
ATOM   1638 C CD1 . TYR A 1 209 ? 11.13657  5.00456   44.20823 1.000 27.58091 ? 203 TYR A CD1 1 
ATOM   1639 C CD2 . TYR A 1 209 ? 9.11697   6.21106   44.51178 1.000 28.18007 ? 203 TYR A CD2 1 
ATOM   1640 C CE1 . TYR A 1 209 ? 11.51537  5.85489   43.17530 1.000 31.11756 ? 203 TYR A CE1 1 
ATOM   1641 C CE2 . TYR A 1 209 ? 9.47895   7.09686   43.46235 1.000 29.46646 ? 203 TYR A CE2 1 
ATOM   1642 C CZ  . TYR A 1 209 ? 10.68177  6.93567   42.82748 1.000 33.81074 ? 203 TYR A CZ  1 
ATOM   1643 O OH  . TYR A 1 209 ? 11.04320  7.80751   41.80737 1.000 38.08063 ? 203 TYR A OH  1 
ATOM   1644 N N   . THR A 1 210 ? 7.52797   3.25249   48.76255 1.000 20.62157 ? 204 THR A N   1 
ATOM   1645 C CA  . THR A 1 210 ? 7.10701   2.04875   49.47959 1.000 22.65733 ? 204 THR A CA  1 
ATOM   1646 C C   . THR A 1 210 ? 5.69975   2.23697   50.05004 1.000 20.01737 ? 204 THR A C   1 
ATOM   1647 O O   . THR A 1 210 ? 5.18870   3.35028   50.18086 1.000 20.64026 ? 204 THR A O   1 
ATOM   1648 C CB  A THR A 1 210 ? 8.06751   1.71244   50.63062 0.884 25.79236 ? 204 THR A CB  1 
ATOM   1649 C CB  B THR A 1 210 ? 8.08843   1.60559   50.59216 0.116 23.43381 ? 204 THR A CB  1 
ATOM   1650 O OG1 A THR A 1 210 ? 7.77434   2.56073   51.73702 0.884 30.35828 ? 204 THR A OG1 1 
ATOM   1651 O OG1 B THR A 1 210 ? 7.71100   0.30668   51.07859 0.116 23.79159 ? 204 THR A OG1 1 
ATOM   1652 C CG2 A THR A 1 210 ? 9.55287   1.90727   50.21181 0.884 25.21657 ? 204 THR A CG2 1 
ATOM   1653 C CG2 B THR A 1 210 ? 8.09014   2.54288   51.73632 0.116 24.00023 ? 204 THR A CG2 1 
ATOM   1654 N N   . LYS A 1 211 ? 5.07298   1.09890   50.34293 1.000 17.88227 ? 205 LYS A N   1 
ATOM   1655 C CA  . LYS A 1 211 ? 3.66238   1.07619   50.73245 1.000 16.82713 ? 205 LYS A CA  1 
ATOM   1656 C C   . LYS A 1 211 ? 3.41497   1.86499   52.00960 1.000 15.88512 ? 205 LYS A C   1 
ATOM   1657 O O   . LYS A 1 211 ? 2.30005   2.39641   52.21198 1.000 15.50640 ? 205 LYS A O   1 
ATOM   1658 C CB  . LYS A 1 211 ? 3.24032   -0.36776  50.88915 1.000 18.29676 ? 205 LYS A CB  1 
ATOM   1659 C CG  . LYS A 1 211 ? 3.13001   -1.05969  49.54960 1.000 18.19787 ? 205 LYS A CG  1 
ATOM   1660 C CD  . LYS A 1 211 ? 2.86462   -2.54970  49.71767 1.000 19.08372 ? 205 LYS A CD  1 
ATOM   1661 C CE  . LYS A 1 211 ? 2.87170   -3.24402  48.34642 1.000 19.89446 ? 205 LYS A CE  1 
ATOM   1662 N NZ  . LYS A 1 211 ? 2.73735   -4.72045  48.42449 1.000 21.21646 ? 205 LYS A NZ  1 
ATOM   1663 N N   . SER A 1 212 ? 4.43473   1.96486   52.87099 1.000 15.15735 ? 206 SER A N   1 
ATOM   1664 C CA  . SER A 1 212 ? 4.25923   2.68922   54.12092 1.000 16.95687 ? 206 SER A CA  1 
ATOM   1665 C C   . SER A 1 212 ? 3.89467   4.15996   53.91929 1.000 15.82168 ? 206 SER A C   1 
ATOM   1666 O O   . SER A 1 212 ? 3.31889   4.78870   54.84064 1.000 16.59581 ? 206 SER A O   1 
ATOM   1667 C CB  . SER A 1 212 ? 5.52981   2.53553   54.98920 1.000 19.32137 ? 206 SER A CB  1 
ATOM   1668 O OG  . SER A 1 212 ? 6.64975   2.99095   54.30055 1.000 22.03560 ? 206 SER A OG  1 
ATOM   1669 N N   . ILE A 1 213 ? 4.20221   4.73263   52.75528 1.000 16.36160 ? 207 ILE A N   1 
ATOM   1670 C CA  . ILE A 1 213 ? 3.81680   6.11823   52.47962 1.000 15.70971 ? 207 ILE A CA  1 
ATOM   1671 C C   . ILE A 1 213 ? 2.28908   6.27819   52.52599 1.000 15.83599 ? 207 ILE A C   1 
ATOM   1672 O O   . ILE A 1 213 ? 1.76472   7.27819   53.04225 1.000 16.15268 ? 207 ILE A O   1 
ATOM   1673 C CB  . ILE A 1 213 ? 4.43912   6.55218   51.12637 1.000 19.67524 ? 207 ILE A CB  1 
ATOM   1674 C CG1 . ILE A 1 213 ? 4.92259   7.97257   51.23567 0.687 24.47982 ? 207 ILE A CG1 1 
ATOM   1675 C CG2 . ILE A 1 213 ? 3.65277   6.16351   49.89003 0.838 21.32117 ? 207 ILE A CG2 1 
ATOM   1676 C CD1 . ILE A 1 213 ? 6.21956   7.96336   52.02464 0.646 24.63062 ? 207 ILE A CD1 1 
ATOM   1677 N N   . ASP A 1 214 ? 1.56064   5.29355   52.01374 1.000 13.94076 ? 208 ASP A N   1 
ATOM   1678 C CA  . ASP A 1 214 ? 0.10843   5.41409   51.96524 1.000 13.33101 ? 208 ASP A CA  1 
ATOM   1679 C C   . ASP A 1 214 ? -0.47555  5.21983   53.34292 1.000 13.84053 ? 208 ASP A C   1 
ATOM   1680 O O   . ASP A 1 214 ? -1.51589  5.82097   53.65264 1.000 13.39384 ? 208 ASP A O   1 
ATOM   1681 C CB  . ASP A 1 214 ? -0.49811  4.37971   51.01396 1.000 13.08708 ? 208 ASP A CB  1 
ATOM   1682 C CG  . ASP A 1 214 ? -0.34056  4.73295   49.53324 1.000 14.20825 ? 208 ASP A CG  1 
ATOM   1683 O OD1 . ASP A 1 214 ? -0.29260  5.93427   49.15755 1.000 14.10708 ? 208 ASP A OD1 1 
ATOM   1684 O OD2 . ASP A 1 214 ? -0.32628  3.76211   48.72529 1.000 15.47662 ? 208 ASP A OD2 1 
ATOM   1685 N N   . ILE A 1 215 ? 0.11829   4.31708   54.15610 1.000 12.22272 ? 209 ILE A N   1 
ATOM   1686 C CA  . ILE A 1 215 ? -0.44358  4.09077   55.48699 1.000 12.36303 ? 209 ILE A CA  1 
ATOM   1687 C C   . ILE A 1 215 ? -0.34759  5.36354   56.31458 1.000 13.92579 ? 209 ILE A C   1 
ATOM   1688 O O   . ILE A 1 215 ? -1.26240  5.68657   57.10020 1.000 14.20406 ? 209 ILE A O   1 
ATOM   1689 C CB  . ILE A 1 215 ? 0.26945   2.91345   56.18934 1.000 13.11800 ? 209 ILE A CB  1 
ATOM   1690 C CG1 . ILE A 1 215 ? -0.04376  1.59319   55.47174 1.000 14.54379 ? 209 ILE A CG1 1 
ATOM   1691 C CG2 . ILE A 1 215 ? -0.16032  2.86492   57.65075 1.000 14.99698 ? 209 ILE A CG2 1 
ATOM   1692 C CD1 . ILE A 1 215 ? -1.50997  1.20968   55.50184 1.000 15.38031 ? 209 ILE A CD1 1 
ATOM   1693 N N   . TRP A 1 216 ? 0.77739   6.09970   56.18605 1.000 13.86201 ? 210 TRP A N   1 
ATOM   1694 C CA  . TRP A 1 216 ? 0.88194   7.37173   56.89656 1.000 13.57169 ? 210 TRP A CA  1 
ATOM   1695 C C   . TRP A 1 216 ? -0.28447  8.27713   56.51538 1.000 13.42487 ? 210 TRP A C   1 
ATOM   1696 O O   . TRP A 1 216 ? -0.94455  8.85716   57.38611 1.000 13.99272 ? 210 TRP A O   1 
ATOM   1697 C CB  . TRP A 1 216 ? 2.24626   8.04653   56.62352 1.000 12.68362 ? 210 TRP A CB  1 
ATOM   1698 C CG  . TRP A 1 216 ? 2.33308   9.35132   57.35982 1.000 13.24469 ? 210 TRP A CG  1 
ATOM   1699 C CD1 . TRP A 1 216 ? 1.86867   10.57981  56.93875 1.000 13.63376 ? 210 TRP A CD1 1 
ATOM   1700 C CD2 . TRP A 1 216 ? 2.84235   9.54347   58.67490 1.000 13.42749 ? 210 TRP A CD2 1 
ATOM   1701 N NE1 . TRP A 1 216 ? 2.09805   11.52751  57.92325 1.000 15.48281 ? 210 TRP A NE1 1 
ATOM   1702 C CE2 . TRP A 1 216 ? 2.69231   10.90600  58.99261 1.000 14.83143 ? 210 TRP A CE2 1 
ATOM   1703 C CE3 . TRP A 1 216 ? 3.42006   8.67926   59.63514 1.000 14.11958 ? 210 TRP A CE3 1 
ATOM   1704 C CZ2 . TRP A 1 216 ? 3.08212   11.43796  60.22515 1.000 15.48329 ? 210 TRP A CZ2 1 
ATOM   1705 C CZ3 . TRP A 1 216 ? 3.83540   9.21945   60.86755 1.000 14.46732 ? 210 TRP A CZ3 1 
ATOM   1706 C CH2 . TRP A 1 216 ? 3.65438   10.59332  61.14272 1.000 15.82486 ? 210 TRP A CH2 1 
ATOM   1707 N N   . SER A 1 217 ? -0.55533  8.40800   55.21552 1.000 13.02816 ? 211 SER A N   1 
ATOM   1708 C CA  . SER A 1 217 ? -1.64756  9.27861   54.78037 1.000 13.08920 ? 211 SER A CA  1 
ATOM   1709 C C   . SER A 1 217 ? -2.96839  8.82449   55.38236 1.000 13.76648 ? 211 SER A C   1 
ATOM   1710 O O   . SER A 1 217 ? -3.76774  9.65582   55.81659 1.000 15.28659 ? 211 SER A O   1 
ATOM   1711 C CB  . SER A 1 217 ? -1.75093  9.30286   53.25577 1.000 13.04019 ? 211 SER A CB  1 
ATOM   1712 O OG  . SER A 1 217 ? -0.50800  9.71994   52.70699 1.000 14.66918 ? 211 SER A OG  1 
ATOM   1713 N N   . VAL A 1 218 ? -3.22767  7.51080   55.41021 1.000 12.59213 ? 212 VAL A N   1 
ATOM   1714 C CA  . VAL A 1 218 ? -4.48103  7.03345   56.01853 1.000 13.87921 ? 212 VAL A CA  1 
ATOM   1715 C C   . VAL A 1 218 ? -4.53376  7.39233   57.51000 1.000 13.41249 ? 212 VAL A C   1 
ATOM   1716 O O   . VAL A 1 218 ? -5.59730  7.74501   58.03422 1.000 13.82970 ? 212 VAL A O   1 
ATOM   1717 C CB  . VAL A 1 218 ? -4.65550  5.52346   55.79351 1.000 13.43221 ? 212 VAL A CB  1 
ATOM   1718 C CG1 . VAL A 1 218 ? -5.89995  4.99487   56.51079 1.000 15.13962 ? 212 VAL A CG1 1 
ATOM   1719 C CG2 . VAL A 1 218 ? -4.74560  5.22466   54.30304 1.000 15.53966 ? 212 VAL A CG2 1 
ATOM   1720 N N   . GLY A 1 219 ? -3.39096  7.29367   58.21556 1.000 13.03677 ? 213 GLY A N   1 
ATOM   1721 C CA  . GLY A 1 219 ? -3.36688  7.71044   59.60720 1.000 11.80567 ? 213 GLY A CA  1 
ATOM   1722 C C   . GLY A 1 219 ? -3.73651  9.17460   59.75747 1.000 14.77975 ? 213 GLY A C   1 
ATOM   1723 O O   . GLY A 1 219 ? -4.50714  9.54887   60.65358 1.000 14.76949 ? 213 GLY A O   1 
ATOM   1724 N N   . CYS A 1 220 ? -3.22251  10.02213  58.85045 1.000 12.76423 ? 214 CYS A N   1 
ATOM   1725 C CA  . CYS A 1 220 ? -3.58680  11.43269  58.89557 1.000 14.19685 ? 214 CYS A CA  1 
ATOM   1726 C C   . CYS A 1 220 ? -5.08395  11.62119  58.65750 1.000 13.96338 ? 214 CYS A C   1 
ATOM   1727 O O   . CYS A 1 220 ? -5.71519  12.50099  59.26976 1.000 15.67576 ? 214 CYS A O   1 
ATOM   1728 C CB  . CYS A 1 220 ? -2.80904  12.20201  57.84726 1.000 13.76433 ? 214 CYS A CB  1 
ATOM   1729 S SG  . CYS A 1 220 ? -1.05871  12.32270  58.18185 1.000 15.63373 ? 214 CYS A SG  1 
ATOM   1730 N N   . ILE A 1 221 ? -5.66910  10.81349  57.76851 1.000 13.83673 ? 215 ILE A N   1 
ATOM   1731 C CA  . ILE A 1 221 ? -7.10173  10.92730  57.47653 1.000 14.22829 ? 215 ILE A CA  1 
ATOM   1732 C C   . ILE A 1 221 ? -7.90910  10.48363  58.66633 1.000 13.69257 ? 215 ILE A C   1 
ATOM   1733 O O   . ILE A 1 221 ? -8.91835  11.10954  59.00979 1.000 15.61703 ? 215 ILE A O   1 
ATOM   1734 C CB  . ILE A 1 221 ? -7.44861  10.13671  56.20516 1.000 14.03887 ? 215 ILE A CB  1 
ATOM   1735 C CG1 . ILE A 1 221 ? -6.77571  10.80992  54.98956 1.000 14.87904 ? 215 ILE A CG1 1 
ATOM   1736 C CG2 . ILE A 1 221 ? -8.97629  10.02353  56.02039 1.000 16.34783 ? 215 ILE A CG2 1 
ATOM   1737 C CD1 . ILE A 1 221 ? -6.62037  9.91267   53.82343 1.000 15.30740 ? 215 ILE A CD1 1 
ATOM   1738 N N   . LEU A 1 222 ? -7.48586  9.40400   59.32804 1.000 14.50487 ? 216 LEU A N   1 
ATOM   1739 C CA  . LEU A 1 222 ? -8.20085  8.97126   60.53756 1.000 14.82208 ? 216 LEU A CA  1 
ATOM   1740 C C   . LEU A 1 222 ? -8.19317  10.07128  61.59398 1.000 15.92419 ? 216 LEU A C   1 
ATOM   1741 O O   . LEU A 1 222 ? -9.23102  10.37216  62.20814 1.000 14.62194 ? 216 LEU A O   1 
ATOM   1742 C CB  . LEU A 1 222 ? -7.57468  7.67728   61.08287 1.000 15.17061 ? 216 LEU A CB  1 
ATOM   1743 C CG  . LEU A 1 222 ? -8.07772  7.23950   62.46960 1.000 14.85526 ? 216 LEU A CG  1 
ATOM   1744 C CD1 . LEU A 1 222 ? -9.62547  7.03046   62.49821 1.000 15.55139 ? 216 LEU A CD1 1 
ATOM   1745 C CD2 . LEU A 1 222 ? -7.33468  5.93296   62.89504 1.000 17.06685 ? 216 LEU A CD2 1 
ATOM   1746 N N   . ALA A 1 223 ? -7.02291  10.66038  61.85365 1.000 15.06879 ? 217 ALA A N   1 
ATOM   1747 C CA  . ALA A 1 223 ? -6.95066  11.73503  62.85264 1.000 15.33618 ? 217 ALA A CA  1 
ATOM   1748 C C   . ALA A 1 223 ? -7.90030  12.86623  62.48314 1.000 17.40276 ? 217 ALA A C   1 
ATOM   1749 O O   . ALA A 1 223 ? -8.56200  13.45517  63.35575 1.000 17.97608 ? 217 ALA A O   1 
ATOM   1750 C CB  . ALA A 1 223 ? -5.50152  12.26781  62.94590 1.000 15.70804 ? 217 ALA A CB  1 
ATOM   1751 N N   . GLU A 1 224 ? -7.95568  13.19981  61.18576 1.000 16.62726 ? 218 GLU A N   1 
ATOM   1752 C CA  . GLU A 1 224 ? -8.79043  14.28558  60.72915 1.000 16.58899 ? 218 GLU A CA  1 
ATOM   1753 C C   . GLU A 1 224 ? -10.27331 13.92516  60.88852 1.000 17.37644 ? 218 GLU A C   1 
ATOM   1754 O O   . GLU A 1 224 ? -11.09119 14.79061  61.19423 1.000 21.50234 ? 218 GLU A O   1 
ATOM   1755 C CB  . GLU A 1 224 ? -8.43935  14.61133  59.27334 1.000 17.45029 ? 218 GLU A CB  1 
ATOM   1756 C CG  . GLU A 1 224 ? -9.04858  15.92692  58.78902 1.000 18.81790 ? 218 GLU A CG  1 
ATOM   1757 C CD  . GLU A 1 224 ? -8.31815  16.43549  57.51397 1.000 20.59850 ? 218 GLU A CD  1 
ATOM   1758 O OE1 . GLU A 1 224 ? -7.20438  15.94808  57.18651 1.000 20.41957 ? 218 GLU A OE1 1 
ATOM   1759 O OE2 . GLU A 1 224 ? -8.83693  17.33793  56.87143 1.000 22.06634 ? 218 GLU A OE2 1 
ATOM   1760 N N   . MET A 1 225 ? -10.63354 12.65033  60.72590 1.000 17.33926 ? 219 MET A N   1 
ATOM   1761 C CA  . MET A 1 225 ? -12.03885 12.25888  60.94195 1.000 17.90303 ? 219 MET A CA  1 
ATOM   1762 C C   . MET A 1 225 ? -12.41658 12.40328  62.42300 1.000 20.40740 ? 219 MET A C   1 
ATOM   1763 O O   . MET A 1 225 ? -13.58764 12.67951  62.76202 1.000 21.26227 ? 219 MET A O   1 
ATOM   1764 C CB  . MET A 1 225 ? -12.21866 10.79941  60.48948 1.000 17.59524 ? 219 MET A CB  1 
ATOM   1765 C CG  . MET A 1 225 ? -12.30609 10.66517  58.95936 1.000 17.39969 ? 219 MET A CG  1 
ATOM   1766 S SD  . MET A 1 225 ? -12.89465 9.08205   58.38290 1.000 18.58409 ? 219 MET A SD  1 
ATOM   1767 C CE  . MET A 1 225 ? -11.55692 7.91034   58.81985 1.000 18.77572 ? 219 MET A CE  1 
ATOM   1768 N N   . LEU A 1 226 ? -11.44300 12.23000  63.30976 1.000 19.99487 ? 220 LEU A N   1 
ATOM   1769 C CA  . LEU A 1 226 ? -11.71451 12.26804  64.74015 1.000 22.19483 ? 220 LEU A CA  1 
ATOM   1770 C C   . LEU A 1 226 ? -11.96906 13.67732  65.22200 1.000 23.93057 ? 220 LEU A C   1 
ATOM   1771 O O   . LEU A 1 226 ? -12.69212 13.87023  66.20375 1.000 27.34395 ? 220 LEU A O   1 
ATOM   1772 C CB  . LEU A 1 226 ? -10.54435 11.67304  65.51780 1.000 22.58640 ? 220 LEU A CB  1 
ATOM   1773 C CG  . LEU A 1 226 ? -10.40211 10.16679  65.35186 1.000 20.86069 ? 220 LEU A CG  1 
ATOM   1774 C CD1 . LEU A 1 226 ? -9.03427  9.68780   65.89583 1.000 22.64727 ? 220 LEU A CD1 1 
ATOM   1775 C CD2 . LEU A 1 226 ? -11.52812 9.39955   66.02502 1.000 21.46582 ? 220 LEU A CD2 1 
ATOM   1776 N N   . SER A 1 227 ? -11.39337 14.68244  64.55901 1.000 23.62950 ? 221 SER A N   1 
ATOM   1777 C CA  . SER A 1 227 ? -11.49044 16.05333  65.06370 1.000 26.29081 ? 221 SER A CA  1 
ATOM   1778 C C   . SER A 1 227 ? -11.94081 17.09524  64.05093 1.000 25.72313 ? 221 SER A C   1 
ATOM   1779 O O   . SER A 1 227 ? -12.12355 18.26388  64.43324 1.000 27.40395 ? 221 SER A O   1 
ATOM   1780 C CB  . SER A 1 227 ? -10.13781 16.50470  65.60973 1.000 28.34392 ? 221 SER A CB  1 
ATOM   1781 O OG  . SER A 1 227 ? -9.26451  16.60692  64.50986 1.000 28.79998 ? 221 SER A OG  1 
ATOM   1782 N N   . ASN A 1 228 ? -12.12505 16.72420  62.78986 1.000 24.73708 ? 222 ASN A N   1 
ATOM   1783 C CA  . ASN A 1 228 ? -12.49494 17.61838  61.70407 1.000 24.88912 ? 222 ASN A CA  1 
ATOM   1784 C C   . ASN A 1 228 ? -11.42782 18.65707  61.38878 1.000 27.09094 ? 222 ASN A C   1 
ATOM   1785 O O   . ASN A 1 228 ? -11.71201 19.61112  60.68450 1.000 32.02631 ? 222 ASN A O   1 
ATOM   1786 C CB  . ASN A 1 228 ? -13.82432 18.35428  61.97724 1.000 24.90440 ? 222 ASN A CB  1 
ATOM   1787 C CG  . ASN A 1 228 ? -15.00037 17.42557  61.98821 1.000 25.42750 ? 222 ASN A CG  1 
ATOM   1788 O OD1 . ASN A 1 228 ? -15.28094 16.78552  63.00973 1.000 26.81481 ? 222 ASN A OD1 1 
ATOM   1789 N ND2 . ASN A 1 228 ? -15.68863 17.30842  60.85941 1.000 24.93757 ? 222 ASN A ND2 1 
ATOM   1790 N N   . ARG A 1 229 ? -10.20303 18.47736  61.85302 1.000 25.71372 ? 223 ARG A N   1 
ATOM   1791 C CA  . ARG A 1 229 ? -9.08234  19.37813  61.62684 1.000 26.31467 ? 223 ARG A CA  1 
ATOM   1792 C C   . ARG A 1 229 ? -7.91849  18.53421  61.12674 1.000 23.58673 ? 223 ARG A C   1 
ATOM   1793 O O   . ARG A 1 229 ? -7.69049  17.45337  61.67595 1.000 22.00349 ? 223 ARG A O   1 
ATOM   1794 C CB  . ARG A 1 229 ? -8.65286  20.03602  62.95380 1.000 30.45173 ? 223 ARG A CB  1 
ATOM   1795 C CG  . ARG A 1 229 ? -9.28648  21.33193  63.38078 0.844 34.80420 ? 223 ARG A CG  1 
ATOM   1796 C CD  . ARG A 1 229 ? -8.15409  22.34532  63.24927 0.189 36.36567 ? 223 ARG A CD  1 
ATOM   1797 N NE  . ARG A 1 229 ? -7.02275  21.98349  64.10435 0.387 37.65338 ? 223 ARG A NE  1 
ATOM   1798 C CZ  . ARG A 1 229 ? -5.78927  21.73150  63.66731 0.426 38.53516 ? 223 ARG A CZ  1 
ATOM   1799 N NH1 . ARG A 1 229 ? -5.49310  21.73171  62.37692 0.755 38.03218 ? 223 ARG A NH1 1 
ATOM   1800 N NH2 . ARG A 1 229 ? -4.82778  21.45607  64.54608 0.507 39.72243 ? 223 ARG A NH2 1 
ATOM   1801 N N   . PRO A 1 230 ? -7.14370  18.97467  60.14048 1.000 23.54294 ? 224 PRO A N   1 
ATOM   1802 C CA  . PRO A 1 230 ? -5.92981  18.21039  59.82022 1.000 22.39335 ? 224 PRO A CA  1 
ATOM   1803 C C   . PRO A 1 230 ? -4.99168  18.16294  61.01974 1.000 21.45224 ? 224 PRO A C   1 
ATOM   1804 O O   . PRO A 1 230 ? -4.82415  19.15036  61.74620 1.000 21.43560 ? 224 PRO A O   1 
ATOM   1805 C CB  . PRO A 1 230 ? -5.32372  18.96514  58.63263 1.000 25.20112 ? 224 PRO A CB  1 
ATOM   1806 C CG  . PRO A 1 230 ? -5.95423  20.30211  58.65001 1.000 28.40562 ? 224 PRO A CG  1 
ATOM   1807 C CD  . PRO A 1 230 ? -7.35524  20.06893  59.16731 1.000 26.84068 ? 224 PRO A CD  1 
ATOM   1808 N N   . ILE A 1 231 ? -4.41324  16.98241  61.25341 1.000 20.50868 ? 225 ILE A N   1 
ATOM   1809 C CA  . ILE A 1 231 ? -3.57431  16.81554  62.42577 1.000 20.14477 ? 225 ILE A CA  1 
ATOM   1810 C C   . ILE A 1 231 ? -2.22274  17.52194  62.25229 1.000 20.58549 ? 225 ILE A C   1 
ATOM   1811 O O   . ILE A 1 231 ? -1.69362  18.08230  63.22189 1.000 21.91727 ? 225 ILE A O   1 
ATOM   1812 C CB  A ILE A 1 231 ? -3.40574  15.31775  62.75319 0.634 19.06823 ? 225 ILE A CB  1 
ATOM   1813 C CB  B ILE A 1 231 ? -3.43308  15.31597  62.75194 0.366 19.34723 ? 225 ILE A CB  1 
ATOM   1814 C CG1 A ILE A 1 231 ? -2.37789  15.13392  63.87704 0.634 19.90902 ? 225 ILE A CG1 1 
ATOM   1815 C CG1 B ILE A 1 231 ? -2.59733  15.12400  64.01513 0.366 19.71723 ? 225 ILE A CG1 1 
ATOM   1816 C CG2 A ILE A 1 231 ? -2.99347  14.49029  61.49839 0.634 17.55005 ? 225 ILE A CG2 1 
ATOM   1817 C CG2 B ILE A 1 231 ? -2.83116  14.52871  61.57105 0.366 18.57908 ? 225 ILE A CG2 1 
ATOM   1818 C CD1 A ILE A 1 231 ? -2.33090  13.75418  64.50159 0.634 20.05771 ? 225 ILE A CD1 1 
ATOM   1819 C CD1 B ILE A 1 231 ? -3.27618  15.56016  65.25834 0.366 20.28785 ? 225 ILE A CD1 1 
ATOM   1820 N N   . PHE A 1 232 ? -1.67248  17.56647  61.02392 1.000 18.66997 ? 226 PHE A N   1 
ATOM   1821 C CA  . PHE A 1 232 ? -0.34707  18.15110  60.73920 1.000 19.31166 ? 226 PHE A CA  1 
ATOM   1822 C C   . PHE A 1 232 ? -0.42775  19.17133  59.60513 1.000 21.77694 ? 226 PHE A C   1 
ATOM   1823 O O   . PHE A 1 232 ? 0.03854   18.91593  58.47694 1.000 22.00952 ? 226 PHE A O   1 
ATOM   1824 C CB  . PHE A 1 232 ? 0.67484   17.07787  60.36310 1.000 17.83959 ? 226 PHE A CB  1 
ATOM   1825 C CG  . PHE A 1 232 ? 0.75736   15.89230  61.30322 1.000 17.35032 ? 226 PHE A CG  1 
ATOM   1826 C CD1 . PHE A 1 232 ? 1.11673   16.05155  62.62515 1.000 17.88083 ? 226 PHE A CD1 1 
ATOM   1827 C CD2 . PHE A 1 232 ? 0.56835   14.60867  60.81923 1.000 15.99089 ? 226 PHE A CD2 1 
ATOM   1828 C CE1 . PHE A 1 232 ? 1.27936   14.94907  63.46800 1.000 16.90931 ? 226 PHE A CE1 1 
ATOM   1829 C CE2 . PHE A 1 232 ? 0.69824   13.47735  61.65127 1.000 15.38057 ? 226 PHE A CE2 1 
ATOM   1830 C CZ  . PHE A 1 232 ? 1.06209   13.63169  63.00068 1.000 15.54413 ? 226 PHE A CZ  1 
ATOM   1831 N N   . PRO A 1 233 ? -1.01744  20.33781  59.85797 1.000 25.49249 ? 227 PRO A N   1 
ATOM   1832 C CA  . PRO A 1 233 ? -1.23695  21.30474  58.76197 1.000 26.51136 ? 227 PRO A CA  1 
ATOM   1833 C C   . PRO A 1 233 ? -0.02968  22.21335  58.56253 1.000 28.67395 ? 227 PRO A C   1 
ATOM   1834 O O   . PRO A 1 233 ? -0.02009  23.42789  58.88224 1.000 29.57895 ? 227 PRO A O   1 
ATOM   1835 C CB  . PRO A 1 233 ? -2.46824  22.06443  59.25556 1.000 28.23171 ? 227 PRO A CB  1 
ATOM   1836 C CG  . PRO A 1 233 ? -2.23852  22.13499  60.74950 1.000 26.87919 ? 227 PRO A CG  1 
ATOM   1837 C CD  . PRO A 1 233 ? -1.65359  20.78070  61.11333 1.000 25.66740 ? 227 PRO A CD  1 
ATOM   1838 N N   . GLY A 1 234 ? 1.03420   21.62756  58.03789 1.000 28.36472 ? 228 GLY A N   1 
ATOM   1839 C CA  . GLY A 1 234 ? 2.24496   22.40205  57.81912 1.000 28.41734 ? 228 GLY A CA  1 
ATOM   1840 C C   . GLY A 1 234 ? 2.04493   23.45395  56.74775 1.000 31.41372 ? 228 GLY A C   1 
ATOM   1841 O O   . GLY A 1 234 ? 1.25465   23.29199  55.81032 1.000 32.08964 ? 228 GLY A O   1 
ATOM   1842 N N   . LYS A 1 235 ? 2.79917   24.54463  56.88294 1.000 33.49666 ? 229 LYS A N   1 
ATOM   1843 C CA  . LYS A 1 235 ? 2.66739   25.65893  55.96057 1.000 36.68018 ? 229 LYS A CA  1 
ATOM   1844 C C   . LYS A 1 235 ? 3.70841   25.64234  54.85173 1.000 37.47539 ? 229 LYS A C   1 
ATOM   1845 O O   . LYS A 1 235 ? 3.59344   26.41122  53.88932 1.000 41.14291 ? 229 LYS A O   1 
ATOM   1846 C CB  . LYS A 1 235 ? 2.71361   26.96549  56.74948 1.000 41.07459 ? 229 LYS A CB  1 
ATOM   1847 C CG  . LYS A 1 235 ? 1.49014   27.15193  57.66749 0.881 43.29529 ? 229 LYS A CG  1 
ATOM   1848 C CD  . LYS A 1 235 ? 1.55616   28.53183  58.33499 0.863 45.96072 ? 229 LYS A CD  1 
ATOM   1849 C CE  . LYS A 1 235 ? 0.31243   28.87610  59.14432 0.816 47.53214 ? 229 LYS A CE  1 
ATOM   1850 N NZ  . LYS A 1 235 ? 0.17338   28.08750  60.39933 0.632 48.12447 ? 229 LYS A NZ  1 
ATOM   1851 N N   . HIS A 1 236 ? 4.73517   24.81649  54.95626 1.000 37.28369 ? 230 HIS A N   1 
ATOM   1852 C CA  . HIS A 1 236 ? 5.69567   24.69363  53.86801 1.000 37.70830 ? 230 HIS A CA  1 
ATOM   1853 C C   . HIS A 1 236 ? 6.45377   23.40455  54.12988 1.000 39.34333 ? 230 HIS A C   1 
ATOM   1854 O O   . HIS A 1 236 ? 6.21340   22.73993  55.13910 1.000 38.63308 ? 230 HIS A O   1 
ATOM   1855 C CB  . HIS A 1 236 ? 6.63549   25.90568  53.78842 1.000 38.28559 ? 230 HIS A CB  1 
ATOM   1856 C CG  . HIS A 1 236 ? 7.00478   26.46434  55.12630 1.000 39.22917 ? 230 HIS A CG  1 
ATOM   1857 N ND1 . HIS A 1 236 ? 6.25096   27.41366  55.79477 1.000 40.46110 ? 230 HIS A ND1 1 
ATOM   1858 C CD2 . HIS A 1 236 ? 8.02018   26.13667  55.95301 1.000 37.52644 ? 230 HIS A CD2 1 
ATOM   1859 C CE1 . HIS A 1 236 ? 6.83908   27.70267  56.93975 1.000 39.11876 ? 230 HIS A CE1 1 
ATOM   1860 N NE2 . HIS A 1 236 ? 7.90002   26.92302  57.07077 1.000 38.77420 ? 230 HIS A NE2 1 
ATOM   1861 N N   . TYR A 1 237 ? 7.42709   23.10624  53.26021 1.000 38.98974 ? 231 TYR A N   1 
ATOM   1862 C CA  . TYR A 1 237 ? 8.05002   21.78333  53.21404 1.000 34.99982 ? 231 TYR A CA  1 
ATOM   1863 C C   . TYR A 1 237 ? 8.59081   21.35121  54.57955 1.000 32.51412 ? 231 TYR A C   1 
ATOM   1864 O O   . TYR A 1 237 ? 8.18950   20.31758  55.09816 1.000 31.28241 ? 231 TYR A O   1 
ATOM   1865 C CB  . TYR A 1 237 ? 9.15455   21.77768  52.13858 1.000 33.36731 ? 231 TYR A CB  1 
ATOM   1866 C CG  . TYR A 1 237 ? 9.87756   20.45631  51.95315 1.000 32.60628 ? 231 TYR A CG  1 
ATOM   1867 C CD1 . TYR A 1 237 ? 10.98849  20.12817  52.73817 1.000 33.51734 ? 231 TYR A CD1 1 
ATOM   1868 C CD2 . TYR A 1 237 ? 9.45000   19.52487  50.99167 1.000 31.75446 ? 231 TYR A CD2 1 
ATOM   1869 C CE1 . TYR A 1 237 ? 11.66142  18.90036  52.56967 1.000 33.77522 ? 231 TYR A CE1 1 
ATOM   1870 C CE2 . TYR A 1 237 ? 10.13842  18.32520  50.79706 1.000 32.62979 ? 231 TYR A CE2 1 
ATOM   1871 C CZ  . TYR A 1 237 ? 11.22981  18.02848  51.58588 0.699 32.29876 ? 231 TYR A CZ  1 
ATOM   1872 O OH  . TYR A 1 237 ? 11.87588  16.84851  51.39972 1.000 31.90643 ? 231 TYR A OH  1 
ATOM   1873 N N   . LEU A 1 238 ? 9.56402   22.09062  55.15642 1.000 33.18122 ? 232 LEU A N   1 
ATOM   1874 C CA  . LEU A 1 238 ? 10.15744  21.56871  56.39395 1.000 32.16037 ? 232 LEU A CA  1 
ATOM   1875 C C   . LEU A 1 238 ? 9.23567   21.78983  57.59012 1.000 34.13832 ? 232 LEU A C   1 
ATOM   1876 O O   . LEU A 1 238 ? 9.24997   20.96357  58.51781 1.000 36.19177 ? 232 LEU A O   1 
ATOM   1877 C CB  . LEU A 1 238 ? 11.59534  22.13426  56.63544 1.000 31.95358 ? 232 LEU A CB  1 
ATOM   1878 C CG  . LEU A 1 238 ? 12.48393  21.35650  57.67250 1.000 29.68331 ? 232 LEU A CG  1 
ATOM   1879 C CD1 . LEU A 1 238 ? 12.60460  19.82696  57.41813 1.000 31.69429 ? 232 LEU A CD1 1 
ATOM   1880 C CD2 . LEU A 1 238 ? 13.88557  21.92330  57.76967 1.000 29.60287 ? 232 LEU A CD2 1 
ATOM   1881 N N   . ASP A 1 239 ? 8.35064   22.80723  57.53994 1.000 33.83225 ? 233 ASP A N   1 
ATOM   1882 C CA  . ASP A 1 239 ? 7.32674   22.97161  58.58999 1.000 31.86792 ? 233 ASP A CA  1 
ATOM   1883 C C   . ASP A 1 239 ? 6.47954   21.72674  58.78404 1.000 27.91044 ? 233 ASP A C   1 
ATOM   1884 O O   . ASP A 1 239 ? 6.02707   21.45468  59.89228 1.000 27.13237 ? 233 ASP A O   1 
ATOM   1885 C CB  . ASP A 1 239 ? 6.38558   24.14313  58.27226 1.000 32.67187 ? 233 ASP A CB  1 
ATOM   1886 C CG  . ASP A 1 239 ? 5.50202   24.54602  59.45661 1.000 33.30901 ? 233 ASP A CG  1 
ATOM   1887 O OD1 . ASP A 1 239 ? 6.01003   24.66303  60.58672 1.000 33.25703 ? 233 ASP A OD1 1 
ATOM   1888 O OD2 . ASP A 1 239 ? 4.29949   24.80679  59.27310 1.000 34.86408 ? 233 ASP A OD2 1 
ATOM   1889 N N   . GLN A 1 240 ? 6.24252   20.96964  57.72481 1.000 26.77900 ? 234 GLN A N   1 
ATOM   1890 C CA  . GLN A 1 240 ? 5.45433   19.74801  57.86210 1.000 24.71258 ? 234 GLN A CA  1 
ATOM   1891 C C   . GLN A 1 240 ? 6.10809   18.82415  58.87725 1.000 25.89568 ? 234 GLN A C   1 
ATOM   1892 O O   . GLN A 1 240 ? 5.42445   18.20101  59.69218 1.000 26.49777 ? 234 GLN A O   1 
ATOM   1893 C CB  . GLN A 1 240 ? 5.33163   19.06136  56.50174 1.000 25.46435 ? 234 GLN A CB  1 
ATOM   1894 C CG  . GLN A 1 240 ? 4.35435   17.92951  56.50721 1.000 22.58119 ? 234 GLN A CG  1 
ATOM   1895 C CD  . GLN A 1 240 ? 2.96392   18.37358  56.88918 1.000 21.70869 ? 234 GLN A CD  1 
ATOM   1896 O OE1 . GLN A 1 240 ? 2.56075   19.50117  56.59323 1.000 23.61101 ? 234 GLN A OE1 1 
ATOM   1897 N NE2 . GLN A 1 240 ? 2.22699   17.51696  57.55171 1.000 22.03609 ? 234 GLN A NE2 1 
ATOM   1898 N N   . LEU A 1 241 ? 7.43869   18.74680  58.84377 1.000 26.08092 ? 235 LEU A N   1 
ATOM   1899 C CA  . LEU A 1 241 ? 8.15047   17.89510  59.78864 1.000 26.34276 ? 235 LEU A CA  1 
ATOM   1900 C C   . LEU A 1 241 ? 8.07339   18.46810  61.20251 1.000 28.38685 ? 235 LEU A C   1 
ATOM   1901 O O   . LEU A 1 241 ? 7.91087   17.70341  62.16880 1.000 28.35548 ? 235 LEU A O   1 
ATOM   1902 C CB  . LEU A 1 241 ? 9.59318   17.69136  59.30511 1.000 26.36279 ? 235 LEU A CB  1 
ATOM   1903 C CG  . LEU A 1 241 ? 10.44759  16.68889  60.07976 1.000 26.32862 ? 235 LEU A CG  1 
ATOM   1904 C CD1 . LEU A 1 241 ? 9.92111   15.23294  60.09721 1.000 26.82183 ? 235 LEU A CD1 1 
ATOM   1905 C CD2 . LEU A 1 241 ? 11.87345  16.74922  59.45650 1.000 27.57555 ? 235 LEU A CD2 1 
ATOM   1906 N N   . ASN A 1 242 ? 8.13392   19.80538  61.34100 1.000 30.62590 ? 236 ASN A N   1 
ATOM   1907 C CA  . ASN A 1 242 ? 7.89434   20.45685  62.64662 1.000 29.16979 ? 236 ASN A CA  1 
ATOM   1908 C C   . ASN A 1 242 ? 6.58355   19.94824  63.26185 1.000 26.91291 ? 236 ASN A C   1 
ATOM   1909 O O   . ASN A 1 242 ? 6.50451   19.65399  64.45565 1.000 26.94460 ? 236 ASN A O   1 
ATOM   1910 C CB  . ASN A 1 242 ? 7.76799   22.01000  62.55039 0.442 28.76760 ? 236 ASN A CB  1 
ATOM   1911 C CG  . ASN A 1 242 ? 8.98856   22.78030  61.92102 0.074 29.74440 ? 236 ASN A CG  1 
ATOM   1912 O OD1 . ASN A 1 242 ? 8.84204   23.97960  61.52570 0.815 28.68479 ? 236 ASN A OD1 1 
ATOM   1913 N ND2 . ASN A 1 242 ? 10.16765  22.15642  61.88732 0.769 31.53315 ? 236 ASN A ND2 1 
ATOM   1914 N N   . HIS A 1 243 ? 5.50954   19.94091  62.47475 1.000 26.82954 ? 237 HIS A N   1 
ATOM   1915 C CA  . HIS A 1 243 ? 4.21885   19.53475  63.01185 1.000 25.52986 ? 237 HIS A CA  1 
ATOM   1916 C C   . HIS A 1 243 ? 4.23449   18.07583  63.44346 1.000 22.85141 ? 237 HIS A C   1 
ATOM   1917 O O   . HIS A 1 243 ? 3.73341   17.73101  64.52633 1.000 22.19655 ? 237 HIS A O   1 
ATOM   1918 C CB  . HIS A 1 243 ? 3.14305   19.79081  61.97160 1.000 26.37110 ? 237 HIS A CB  1 
ATOM   1919 C CG  . HIS A 1 243 ? 2.68232   21.20732  61.93951 1.000 27.85514 ? 237 HIS A CG  1 
ATOM   1920 N ND1 . HIS A 1 243 ? 1.50409   21.61112  62.52337 1.000 31.09506 ? 237 HIS A ND1 1 
ATOM   1921 C CD2 . HIS A 1 243 ? 3.24171   22.31502  61.39392 1.000 27.80069 ? 237 HIS A CD2 1 
ATOM   1922 C CE1 . HIS A 1 243 ? 1.36562   22.91520  62.35664 1.000 32.39785 ? 237 HIS A CE1 1 
ATOM   1923 N NE2 . HIS A 1 243 ? 2.40814   23.36446  61.67524 1.000 30.61052 ? 237 HIS A NE2 1 
ATOM   1924 N N   . ILE A 1 244 ? 4.78667   17.20523  62.61431 1.000 20.14731 ? 238 ILE A N   1 
ATOM   1925 C CA  . ILE A 1 244 ? 4.78939   15.78244  62.94416 1.000 19.66327 ? 238 ILE A CA  1 
ATOM   1926 C C   . ILE A 1 244 ? 5.55070   15.54911  64.23729 1.000 20.26004 ? 238 ILE A C   1 
ATOM   1927 O O   . ILE A 1 244 ? 5.07829   14.86098  65.14936 1.000 20.96967 ? 238 ILE A O   1 
ATOM   1928 C CB  . ILE A 1 244 ? 5.39759   14.97355  61.78557 1.000 18.89209 ? 238 ILE A CB  1 
ATOM   1929 C CG1 . ILE A 1 244 ? 4.48563   15.11577  60.56643 1.000 18.85163 ? 238 ILE A CG1 1 
ATOM   1930 C CG2 . ILE A 1 244 ? 5.55560   13.50688  62.16342 1.000 18.54622 ? 238 ILE A CG2 1 
ATOM   1931 C CD1 . ILE A 1 244 ? 5.07856   14.53662  59.26750 1.000 19.98105 ? 238 ILE A CD1 1 
ATOM   1932 N N   . LEU A 1 245 ? 6.76431   16.09673  64.32443 1.000 20.21790 ? 239 LEU A N   1 
ATOM   1933 C CA  . LEU A 1 245 ? 7.54832   15.89475  65.54077 1.000 21.65108 ? 239 LEU A CA  1 
ATOM   1934 C C   . LEU A 1 245 ? 6.92724   16.58079  66.76790 1.000 22.50932 ? 239 LEU A C   1 
ATOM   1935 O O   . LEU A 1 245 ? 7.14517   16.12619  67.89643 1.000 21.73588 ? 239 LEU A O   1 
ATOM   1936 C CB  . LEU A 1 245 ? 8.97154   16.37972  65.32430 1.000 22.49148 ? 239 LEU A CB  1 
ATOM   1937 C CG  . LEU A 1 245 ? 9.71984   15.65239  64.21373 1.000 22.85688 ? 239 LEU A CG  1 
ATOM   1938 C CD1 . LEU A 1 245 ? 11.13134  16.29997  64.11056 1.000 23.81733 ? 239 LEU A CD1 1 
ATOM   1939 C CD2 . LEU A 1 245 ? 9.85381   14.18210  64.54979 1.000 26.12954 ? 239 LEU A CD2 1 
ATOM   1940 N N   . GLY A 1 246 ? 6.14567   17.65023  66.57870 1.000 22.37260 ? 240 GLY A N   1 
ATOM   1941 C CA  . GLY A 1 246 ? 5.50431   18.29225  67.70864 1.000 21.84961 ? 240 GLY A CA  1 
ATOM   1942 C C   . GLY A 1 246 ? 4.49073   17.41396  68.40421 1.000 22.07500 ? 240 GLY A C   1 
ATOM   1943 O O   . GLY A 1 246 ? 4.16566   17.64846  69.57364 1.000 23.98286 ? 240 GLY A O   1 
ATOM   1944 N N   . ILE A 1 247 ? 3.98615   16.40575  67.72462 1.000 21.27323 ? 241 ILE A N   1 
ATOM   1945 C CA  . ILE A 1 247 ? 3.00940   15.48655  68.29555 1.000 21.24102 ? 241 ILE A CA  1 
ATOM   1946 C C   . ILE A 1 247 ? 3.65009   14.15089  68.63727 1.000 21.02506 ? 241 ILE A C   1 
ATOM   1947 O O   . ILE A 1 247 ? 3.46014   13.61679  69.73321 1.000 21.56474 ? 241 ILE A O   1 
ATOM   1948 C CB  . ILE A 1 247 ? 1.81317   15.32370  67.33559 1.000 21.96396 ? 241 ILE A CB  1 
ATOM   1949 C CG1 . ILE A 1 247 ? 0.94802   16.59553  67.46120 1.000 25.30090 ? 241 ILE A CG1 1 
ATOM   1950 C CG2 . ILE A 1 247 ? 0.95502   14.09645  67.69250 1.000 21.84283 ? 241 ILE A CG2 1 
ATOM   1951 C CD1 . ILE A 1 247 ? -0.15124  16.68067  66.48019 1.000 28.08062 ? 241 ILE A CD1 1 
ATOM   1952 N N   . LEU A 1 248 ? 4.40219   13.57058  67.69185 1.000 20.49066 ? 242 LEU A N   1 
ATOM   1953 C CA  . LEU A 1 248 ? 5.04684   12.28935  67.97946 1.000 21.44639 ? 242 LEU A CA  1 
ATOM   1954 C C   . LEU A 1 248 ? 6.17811   12.41899  68.98908 1.000 21.39138 ? 242 LEU A C   1 
ATOM   1955 O O   . LEU A 1 248 ? 6.52655   11.43033  69.63892 1.000 22.48579 ? 242 LEU A O   1 
ATOM   1956 C CB  A LEU A 1 248 ? 5.55870   11.64277  66.69344 0.458 19.91421 ? 242 LEU A CB  1 
ATOM   1957 C CB  B LEU A 1 248 ? 5.60748   11.67301  66.70053 0.542 20.12508 ? 242 LEU A CB  1 
ATOM   1958 C CG  A LEU A 1 248 ? 4.58290   10.76616  65.88884 0.458 18.75626 ? 242 LEU A CG  1 
ATOM   1959 C CG  B LEU A 1 248 ? 4.62528   11.11800  65.66988 0.542 19.73455 ? 242 LEU A CG  1 
ATOM   1960 C CD1 A LEU A 1 248 ? 3.30046   11.48480  65.51330 0.458 18.03093 ? 242 LEU A CD1 1 
ATOM   1961 C CD1 B LEU A 1 248 ? 5.35486   10.17330  64.72921 0.542 20.28829 ? 242 LEU A CD1 1 
ATOM   1962 C CD2 A LEU A 1 248 ? 5.27551   10.23708  64.63908 0.458 19.19004 ? 242 LEU A CD2 1 
ATOM   1963 C CD2 B LEU A 1 248 ? 3.54899   10.37512  66.39057 0.542 20.48971 ? 242 LEU A CD2 1 
ATOM   1964 N N   . GLY A 1 249 ? 6.75076   13.59772  69.13987 1.000 20.81548 ? 243 GLY A N   1 
ATOM   1965 C CA  . GLY A 1 249 ? 7.93300   13.73468  69.95965 1.000 20.54123 ? 243 GLY A CA  1 
ATOM   1966 C C   . GLY A 1 249 ? 9.18163   13.32167  69.21564 1.000 20.96419 ? 243 GLY A C   1 
ATOM   1967 O O   . GLY A 1 249 ? 9.15071   12.84811  68.06143 1.000 22.19610 ? 243 GLY A O   1 
ATOM   1968 N N   . SER A 1 250 ? 10.31072  13.52444  69.89177 1.000 19.66169 ? 244 SER A N   1 
ATOM   1969 C CA  . SER A 1 250 ? 11.61102  13.19101  69.30011 1.000 19.90151 ? 244 SER A CA  1 
ATOM   1970 C C   . SER A 1 250 ? 11.69498  11.70171  68.96589 1.000 19.44217 ? 244 SER A C   1 
ATOM   1971 O O   . SER A 1 250 ? 11.28003  10.84103  69.77147 1.000 20.95714 ? 244 SER A O   1 
ATOM   1972 C CB  . SER A 1 250 ? 12.73791  13.56265  70.27343 1.000 20.71479 ? 244 SER A CB  1 
ATOM   1973 O OG  . SER A 1 250 ? 12.69332  14.94433  70.54803 1.000 21.61292 ? 244 SER A OG  1 
ATOM   1974 N N   . PRO A 1 251 ? 12.24540  11.35116  67.81225 1.000 17.89026 ? 245 PRO A N   1 
ATOM   1975 C CA  . PRO A 1 251 ? 12.51038  9.93557   67.53099 1.000 18.20760 ? 245 PRO A CA  1 
ATOM   1976 C C   . PRO A 1 251 ? 13.52882  9.32221   68.47733 1.000 18.08366 ? 245 PRO A C   1 
ATOM   1977 O O   . PRO A 1 251 ? 14.46256  9.98438   68.97314 1.000 18.79300 ? 245 PRO A O   1 
ATOM   1978 C CB  . PRO A 1 251 ? 13.04111  9.94522   66.09064 1.000 19.31912 ? 245 PRO A CB  1 
ATOM   1979 C CG  . PRO A 1 251 ? 13.44400  11.33036  65.83487 1.000 22.70219 ? 245 PRO A CG  1 
ATOM   1980 C CD  . PRO A 1 251 ? 12.59023  12.22059  66.67408 1.000 20.15042 ? 245 PRO A CD  1 
ATOM   1981 N N   . SER A 1 252 ? 13.33302  8.03352   68.70902 1.000 18.83079 ? 246 SER A N   1 
ATOM   1982 C CA  . SER A 1 252 ? 14.20141  7.26435   69.56587 1.000 19.03254 ? 246 SER A CA  1 
ATOM   1983 C C   . SER A 1 252 ? 15.56852  7.11742   68.91214 1.000 20.16982 ? 246 SER A C   1 
ATOM   1984 O O   . SER A 1 252 ? 15.74597  7.32476   67.69115 1.000 18.41367 ? 246 SER A O   1 
ATOM   1985 C CB  . SER A 1 252 ? 13.62085  5.87866   69.80869 1.000 19.02264 ? 246 SER A CB  1 
ATOM   1986 O OG  . SER A 1 252 ? 13.59721  5.12920   68.59015 1.000 20.63725 ? 246 SER A OG  1 
ATOM   1987 N N   . GLN A 1 253 ? 16.53899  6.74215   69.72690 1.000 21.65717 ? 247 GLN A N   1 
ATOM   1988 C CA  . GLN A 1 253 ? 17.87618  6.46107   69.18233 1.000 22.49776 ? 247 GLN A CA  1 
ATOM   1989 C C   . GLN A 1 253 ? 17.80002  5.39008   68.10487 1.000 22.08938 ? 247 GLN A C   1 
ATOM   1990 O O   . GLN A 1 253 ? 18.44114  5.49385   67.05453 1.000 22.29669 ? 247 GLN A O   1 
ATOM   1991 C CB  . GLN A 1 253 ? 18.81033  5.97962   70.29612 1.000 25.66456 ? 247 GLN A CB  1 
ATOM   1992 C CG  . GLN A 1 253 ? 20.23790  5.75468   69.87493 1.000 27.62971 ? 247 GLN A CG  1 
ATOM   1993 C CD  A GLN A 1 253 ? 21.12633  5.35973   71.07425 0.522 29.69657 ? 247 GLN A CD  1 
ATOM   1994 C CD  B GLN A 1 253 ? 20.95261  7.06468   69.45964 0.478 29.33851 ? 247 GLN A CD  1 
ATOM   1995 O OE1 A GLN A 1 253 ? 20.77624  4.48234   71.87627 0.522 31.20026 ? 247 GLN A OE1 1 
ATOM   1996 O OE1 B GLN A 1 253 ? 21.19409  7.95480   70.28509 0.478 29.27405 ? 247 GLN A OE1 1 
ATOM   1997 N NE2 A GLN A 1 253 ? 22.25126  6.03380   71.21463 0.522 30.43569 ? 247 GLN A NE2 1 
ATOM   1998 N NE2 B GLN A 1 253 ? 21.30172  7.16710   68.17853 0.478 29.64141 ? 247 GLN A NE2 1 
ATOM   1999 N N   . GLU A 1 254 ? 17.02847  4.33024   68.36251 1.000 20.92827 ? 248 GLU A N   1 
ATOM   2000 C CA  . GLU A 1 254 ? 16.95227  3.25584   67.38919 1.000 21.03888 ? 248 GLU A CA  1 
ATOM   2001 C C   . GLU A 1 254 ? 16.37175  3.76319   66.08072 1.000 21.13418 ? 248 GLU A C   1 
ATOM   2002 O O   . GLU A 1 254 ? 16.86754  3.42582   64.99852 1.000 22.90055 ? 248 GLU A O   1 
ATOM   2003 C CB  . GLU A 1 254 ? 16.13576  2.09750   67.95179 1.000 24.88439 ? 248 GLU A CB  1 
ATOM   2004 C CG  . GLU A 1 254 ? 15.82031  1.02046   66.92762 0.565 25.41222 ? 248 GLU A CG  1 
ATOM   2005 C CD  . GLU A 1 254 ? 15.25781  -0.21997  67.57656 0.457 26.36114 ? 248 GLU A CD  1 
ATOM   2006 O OE1 . GLU A 1 254 ? 15.95147  -0.82853  68.43606 0.398 26.19783 ? 248 GLU A OE1 1 
ATOM   2007 O OE2 . GLU A 1 254 ? 14.10807  -0.56683  67.24108 0.601 26.91053 ? 248 GLU A OE2 1 
ATOM   2008 N N   . ASP A 1 255 ? 15.34316  4.60809   66.15397 1.000 19.84117 ? 249 ASP A N   1 
ATOM   2009 C CA  . ASP A 1 255 ? 14.74453  5.08562   64.93051 1.000 20.18563 ? 249 ASP A CA  1 
ATOM   2010 C C   . ASP A 1 255 ? 15.66037  6.03528   64.19288 1.000 20.92426 ? 249 ASP A C   1 
ATOM   2011 O O   . ASP A 1 255 ? 15.67672  6.00121   62.94557 1.000 21.05021 ? 249 ASP A O   1 
ATOM   2012 C CB  . ASP A 1 255 ? 13.39701  5.73196   65.22584 1.000 18.28797 ? 249 ASP A CB  1 
ATOM   2013 C CG  . ASP A 1 255 ? 12.33747  4.69504   65.47766 0.931 19.26456 ? 249 ASP A CG  1 
ATOM   2014 O OD1 . ASP A 1 255 ? 12.62522  3.48559   65.28195 1.000 21.90232 ? 249 ASP A OD1 1 
ATOM   2015 O OD2 . ASP A 1 255 ? 11.22949  5.08294   65.85843 0.749 20.45140 ? 249 ASP A OD2 1 
ATOM   2016 N N   . LEU A 1 256 ? 16.45031  6.84104   64.93027 1.000 20.97532 ? 250 LEU A N   1 
ATOM   2017 C CA  . LEU A 1 256 ? 17.49101  7.67358   64.31141 1.000 22.38678 ? 250 LEU A CA  1 
ATOM   2018 C C   . LEU A 1 256 ? 18.55523  6.81862   63.64034 1.000 25.62992 ? 250 LEU A C   1 
ATOM   2019 O O   . LEU A 1 256 ? 19.03448  7.15357   62.54706 1.000 26.29359 ? 250 LEU A O   1 
ATOM   2020 C CB  . LEU A 1 256 ? 18.14884  8.55458   65.36632 1.000 26.13908 ? 250 LEU A CB  1 
ATOM   2021 C CG  . LEU A 1 256 ? 17.35728  9.78455   65.73420 1.000 28.73522 ? 250 LEU A CG  1 
ATOM   2022 C CD1 . LEU A 1 256 ? 18.08325  10.57911  66.79167 1.000 30.35345 ? 250 LEU A CD1 1 
ATOM   2023 C CD2 . LEU A 1 256 ? 17.18476  10.62338  64.50980 1.000 32.01055 ? 250 LEU A CD2 1 
ATOM   2024 N N   . ASN A 1 257 ? 18.97860  5.74136   64.29670 1.000 26.16047 ? 251 ASN A N   1 
ATOM   2025 C CA  . ASN A 1 257 ? 20.05174  4.91893   63.74660 1.000 27.75087 ? 251 ASN A CA  1 
ATOM   2026 C C   . ASN A 1 257 ? 19.64026  4.27744   62.42599 1.000 27.84194 ? 251 ASN A C   1 
ATOM   2027 O O   . ASN A 1 257 ? 20.49054  3.89661   61.60777 1.000 30.05130 ? 251 ASN A O   1 
ATOM   2028 C CB  . ASN A 1 257 ? 20.49355  3.83819   64.74913 1.000 29.87275 ? 251 ASN A CB  1 
ATOM   2029 C CG  . ASN A 1 257 ? 21.27979  4.41427   65.91030 0.880 32.27556 ? 251 ASN A CG  1 
ATOM   2030 O OD1 . ASN A 1 257 ? 21.76961  5.53534   65.83875 1.000 34.51673 ? 251 ASN A OD1 1 
ATOM   2031 N ND2 . ASN A 1 257 ? 21.36030  3.67079   67.00284 0.858 31.62958 ? 251 ASN A ND2 1 
HETATM 2032 N N   . CME A 1 258 ? 18.33624  4.19412   62.18021 1.000 26.67549 ? 252 CME A N   1 
HETATM 2033 C CA  . CME A 1 258 ? 17.82586  3.63460   60.94701 1.000 26.59735 ? 252 CME A CA  1 
HETATM 2034 C CB  . CME A 1 258 ? 16.33306  3.21751   61.03016 1.000 28.14665 ? 252 CME A CB  1 
HETATM 2035 S SG  . CME A 1 258 ? 16.08676  1.82746   62.06709 1.000 31.81627 ? 252 CME A SG  1 
HETATM 2036 S SD  . CME A 1 258 ? 17.13124  0.38361   60.98746 0.436 33.61351 ? 252 CME A SD  1 
HETATM 2037 C CE  . CME A 1 258 ? 16.12687  -0.88457  60.35113 0.605 36.48964 ? 252 CME A CE  1 
HETATM 2038 C CZ  . CME A 1 258 ? 15.38870  -0.44714  59.11692 0.529 37.45761 ? 252 CME A CZ  1 
HETATM 2039 O OH  . CME A 1 258 ? 14.60024  -1.58160  58.80452 0.158 37.89579 ? 252 CME A OH  1 
HETATM 2040 C C   . CME A 1 258 ? 17.94505  4.63043   59.79212 1.000 26.81075 ? 252 CME A C   1 
HETATM 2041 O O   . CME A 1 258 ? 17.80188  4.27509   58.62479 1.000 28.71694 ? 252 CME A O   1 
ATOM   2042 N N   . ILE A 1 259 ? 18.19191  5.90482   60.12059 1.000 25.10846 ? 253 ILE A N   1 
ATOM   2043 C CA  . ILE A 1 259 ? 18.40556  6.94774   59.11197 1.000 24.13906 ? 253 ILE A CA  1 
ATOM   2044 C C   . ILE A 1 259 ? 19.90215  7.11222   58.91078 1.000 24.15645 ? 253 ILE A C   1 
ATOM   2045 O O   . ILE A 1 259 ? 20.55837  7.79563   59.69227 1.000 25.66371 ? 253 ILE A O   1 
ATOM   2046 C CB  . ILE A 1 259 ? 17.76521  8.27496   59.53635 1.000 23.88947 ? 253 ILE A CB  1 
ATOM   2047 C CG1 . ILE A 1 259 ? 16.24690  8.11997   59.69513 1.000 23.35649 ? 253 ILE A CG1 1 
ATOM   2048 C CG2 . ILE A 1 259 ? 18.02420  9.37091   58.55536 1.000 23.27662 ? 253 ILE A CG2 1 
ATOM   2049 C CD1 . ILE A 1 259 ? 15.63163  9.33661   60.34201 1.000 24.73647 ? 253 ILE A CD1 1 
ATOM   2050 N N   . ILE A 1 260 ? 20.44572  6.48404   57.87492 1.000 24.11734 ? 254 ILE A N   1 
ATOM   2051 C CA  A ILE A 1 260 ? 21.89482  6.52098   57.73992 0.583 25.32529 ? 254 ILE A CA  1 
ATOM   2052 C CA  B ILE A 1 260 ? 21.89189  6.50525   57.67613 0.417 25.53501 ? 254 ILE A CA  1 
ATOM   2053 C C   . ILE A 1 260 ? 22.34215  7.84573   57.13461 1.000 25.14276 ? 254 ILE A C   1 
ATOM   2054 O O   . ILE A 1 260 ? 23.46599  8.30013   57.40634 1.000 25.66371 ? 254 ILE A O   1 
ATOM   2055 C CB  A ILE A 1 260 ? 22.38220  5.30401   56.92915 0.583 27.73645 ? 254 ILE A CB  1 
ATOM   2056 C CB  B ILE A 1 260 ? 22.29421  5.35926   56.73410 0.417 28.03733 ? 254 ILE A CB  1 
ATOM   2057 C CG1 A ILE A 1 260 ? 23.91007  5.15521   57.04257 0.583 30.05259 ? 254 ILE A CG1 1 
ATOM   2058 C CG1 B ILE A 1 260 ? 21.69220  4.03407   57.20712 0.417 30.02875 ? 254 ILE A CG1 1 
ATOM   2059 C CG2 A ILE A 1 260 ? 21.93893  5.38387   55.45972 0.583 28.53449 ? 254 ILE A CG2 1 
ATOM   2060 C CG2 B ILE A 1 260 ? 23.81383  5.32121   56.55453 0.417 29.31437 ? 254 ILE A CG2 1 
ATOM   2061 C CD1 A ILE A 1 260 ? 24.45690  3.85232   56.43720 0.583 30.63960 ? 254 ILE A CD1 1 
ATOM   2062 C CD1 B ILE A 1 260 ? 21.95723  3.73653   58.65747 0.417 30.96693 ? 254 ILE A CD1 1 
ATOM   2063 N N   . ASN A 1 261 ? 21.49016  8.49926   56.34135 1.000 24.68341 ? 255 ASN A N   1 
ATOM   2064 C CA  . ASN A 1 261 ? 21.88146  9.76296   55.74170 1.000 23.03786 ? 255 ASN A CA  1 
ATOM   2065 C C   . ASN A 1 261 ? 22.25844  10.78529  56.81031 1.000 23.06987 ? 255 ASN A C   1 
ATOM   2066 O O   . ASN A 1 261 ? 21.44572  11.09895  57.69099 1.000 23.67447 ? 255 ASN A O   1 
ATOM   2067 C CB  . ASN A 1 261 ? 20.75143  10.29644  54.87732 1.000 24.59122 ? 255 ASN A CB  1 
ATOM   2068 C CG  . ASN A 1 261 ? 21.19394  11.47637  54.09339 1.000 27.80599 ? 255 ASN A CG  1 
ATOM   2069 O OD1 . ASN A 1 261 ? 21.12431  12.59268  54.60267 1.000 29.53982 ? 255 ASN A OD1 1 
ATOM   2070 N ND2 . ASN A 1 261 ? 21.70266  11.25100  52.85374 1.000 28.88024 ? 255 ASN A ND2 1 
ATOM   2071 N N   . LEU A 1 262 ? 23.48151  11.31075  56.71811 1.000 22.77905 ? 256 LEU A N   1 
ATOM   2072 C CA  . LEU A 1 262 ? 24.01321  12.14956  57.79222 1.000 23.35315 ? 256 LEU A CA  1 
ATOM   2073 C C   . LEU A 1 262 ? 23.29410  13.48086  57.86688 1.000 22.34513 ? 256 LEU A C   1 
ATOM   2074 O O   . LEU A 1 262 ? 23.05387  13.98897  58.97008 1.000 22.72034 ? 256 LEU A O   1 
ATOM   2075 C CB  A LEU A 1 262 ? 25.51270  12.38403  57.58974 0.697 25.93530 ? 256 LEU A CB  1 
ATOM   2076 C CB  B LEU A 1 262 ? 25.51671  12.35518  57.61602 0.303 23.79439 ? 256 LEU A CB  1 
ATOM   2077 C CG  A LEU A 1 262 ? 26.48799  11.38688  58.18383 0.697 26.29054 ? 256 LEU A CG  1 
ATOM   2078 C CG  B LEU A 1 262 ? 26.24353  12.68653  58.91664 0.303 23.09575 ? 256 LEU A CG  1 
ATOM   2079 C CD1 A LEU A 1 262 ? 27.91276  11.63243  57.59531 0.697 26.71338 ? 256 LEU A CD1 1 
ATOM   2080 C CD1 B LEU A 1 262 ? 25.82661  11.72549  60.05497 0.303 21.81964 ? 256 LEU A CD1 1 
ATOM   2081 C CD2 A LEU A 1 262 ? 26.49370  11.49809  59.71229 0.697 26.82836 ? 256 LEU A CD2 1 
ATOM   2082 C CD2 B LEU A 1 262 ? 27.74095  12.65888  58.70627 0.303 23.69807 ? 256 LEU A CD2 1 
ATOM   2083 N N   . LYS A 1 263 ? 22.96664  14.09177  56.72128 1.000 22.60545 ? 257 LYS A N   1 
ATOM   2084 C CA  . LYS A 1 263 ? 22.30798  15.38720  56.79109 1.000 23.60054 ? 257 LYS A CA  1 
ATOM   2085 C C   . LYS A 1 263 ? 20.94161  15.25169  57.46569 1.000 20.90691 ? 257 LYS A C   1 
ATOM   2086 O O   . LYS A 1 263 ? 20.59173  16.06455  58.31891 1.000 21.99520 ? 257 LYS A O   1 
ATOM   2087 C CB  . LYS A 1 263 ? 22.16063  16.00604  55.39910 1.000 25.89457 ? 257 LYS A CB  1 
ATOM   2088 C CG  . LYS A 1 263 ? 23.39137  16.76389  54.96494 0.849 27.47396 ? 257 LYS A CG  1 
ATOM   2089 C CD  . LYS A 1 263 ? 23.15813  17.49833  53.61850 0.841 28.96758 ? 257 LYS A CD  1 
ATOM   2090 C CE  . LYS A 1 263 ? 24.26066  18.47974  53.28283 0.439 30.79644 ? 257 LYS A CE  1 
ATOM   2091 N NZ  . LYS A 1 263 ? 24.00352  19.10328  51.96519 0.542 31.90070 ? 257 LYS A NZ  1 
ATOM   2092 N N   . ALA A 1 264 ? 20.18034  14.21182  57.13096 1.000 19.07373 ? 258 ALA A N   1 
ATOM   2093 C CA  . ALA A 1 264 ? 18.87148  14.01961  57.76530 1.000 19.06946 ? 258 ALA A CA  1 
ATOM   2094 C C   . ALA A 1 264 ? 19.02268  13.68599  59.24302 1.000 18.49745 ? 258 ALA A C   1 
ATOM   2095 O O   . ALA A 1 264 ? 18.31744  14.25730  60.09539 1.000 17.83882 ? 258 ALA A O   1 
ATOM   2096 C CB  . ALA A 1 264 ? 18.08235  12.92401  57.05370 1.000 20.35568 ? 258 ALA A CB  1 
ATOM   2097 N N   . ARG A 1 265 ? 19.90393  12.72896  59.56672 1.000 17.20681 ? 259 ARG A N   1 
ATOM   2098 C CA  . ARG A 1 265 ? 20.10052  12.36718  60.96358 1.000 17.49006 ? 259 ARG A CA  1 
ATOM   2099 C C   . ARG A 1 265 ? 20.54693  13.56271  61.80150 1.000 17.52738 ? 259 ARG A C   1 
ATOM   2100 O O   . ARG A 1 265 ? 20.01387  13.79830  62.90760 1.000 17.64642 ? 259 ARG A O   1 
ATOM   2101 C CB  . ARG A 1 265 ? 21.11074  11.22631  61.09553 1.000 19.54209 ? 259 ARG A CB  1 
ATOM   2102 C CG  . ARG A 1 265 ? 20.97043  10.68234  62.51162 0.661 20.47041 ? 259 ARG A CG  1 
ATOM   2103 C CD  . ARG A 1 265 ? 22.05840  9.78504   62.88909 0.682 22.38846 ? 259 ARG A CD  1 
ATOM   2104 N NE  . ARG A 1 265 ? 22.00416  8.55592   62.10553 0.873 22.67321 ? 259 ARG A NE  1 
ATOM   2105 C CZ  . ARG A 1 265 ? 22.75020  7.50445   62.35923 0.702 23.84797 ? 259 ARG A CZ  1 
ATOM   2106 N NH1 . ARG A 1 265 ? 23.64807  7.51752   63.34346 0.777 26.08361 ? 259 ARG A NH1 1 
ATOM   2107 N NH2 . ARG A 1 265 ? 22.57604  6.41041   61.63330 0.772 23.34499 ? 259 ARG A NH2 1 
ATOM   2108 N N   . ASN A 1 266 ? 21.50632  14.34841  61.29378 1.000 17.48386 ? 260 ASN A N   1 
ATOM   2109 C CA  . ASN A 1 266 ? 22.02293  15.46190  62.07941 1.000 16.49397 ? 260 ASN A CA  1 
ATOM   2110 C C   . ASN A 1 266 ? 21.02176  16.57535  62.20547 1.000 16.55486 ? 260 ASN A C   1 
ATOM   2111 O O   . ASN A 1 266 ? 21.01835  17.27953  63.22388 1.000 17.40422 ? 260 ASN A O   1 
ATOM   2112 C CB  . ASN A 1 266 ? 23.32787  15.98091  61.49415 1.000 17.80504 ? 260 ASN A CB  1 
ATOM   2113 C CG  . ASN A 1 266 ? 24.49513  15.11824  61.88429 1.000 19.02643 ? 260 ASN A CG  1 
ATOM   2114 O OD1 . ASN A 1 266 ? 24.45147  14.36827  62.86382 1.000 21.47657 ? 260 ASN A OD1 1 
ATOM   2115 N ND2 . ASN A 1 266 ? 25.51575  15.18358  61.10765 1.000 19.24620 ? 260 ASN A ND2 1 
ATOM   2116 N N   . TYR A 1 267 ? 20.14053  16.74191  61.23112 1.000 16.52883 ? 261 TYR A N   1 
ATOM   2117 C CA  . TYR A 1 267 ? 19.06511  17.70586  61.43945 1.000 16.87131 ? 261 TYR A CA  1 
ATOM   2118 C C   . TYR A 1 267 ? 18.21776  17.29266  62.64564 1.000 16.33259 ? 261 TYR A C   1 
ATOM   2119 O O   . TYR A 1 267 ? 17.93865  18.09844  63.54908 1.000 15.95925 ? 261 TYR A O   1 
ATOM   2120 C CB  . TYR A 1 267 ? 18.20462  17.83860  60.18692 1.000 15.98099 ? 261 TYR A CB  1 
ATOM   2121 C CG  . TYR A 1 267 ? 16.99532  18.71437  60.50882 1.000 17.14675 ? 261 TYR A CG  1 
ATOM   2122 C CD1 . TYR A 1 267 ? 17.15314  20.08055  60.68080 1.000 18.56545 ? 261 TYR A CD1 1 
ATOM   2123 C CD2 . TYR A 1 267 ? 15.72415  18.17213  60.66109 1.000 18.09394 ? 261 TYR A CD2 1 
ATOM   2124 C CE1 . TYR A 1 267 ? 16.10189  20.88855  61.01807 1.000 18.56567 ? 261 TYR A CE1 1 
ATOM   2125 C CE2 . TYR A 1 267 ? 14.62897  18.98144  60.99473 1.000 18.69478 ? 261 TYR A CE2 1 
ATOM   2126 C CZ  . TYR A 1 267 ? 14.82667  20.33646  61.15294 1.000 18.72643 ? 261 TYR A CZ  1 
ATOM   2127 O OH  . TYR A 1 267 ? 13.78797  21.17465  61.48860 1.000 20.12352 ? 261 TYR A OH  1 
ATOM   2128 N N   . LEU A 1 268 ? 17.83115  16.02702  62.70296 1.000 15.52968 ? 262 LEU A N   1 
ATOM   2129 C CA  . LEU A 1 268 ? 17.00986  15.57897  63.84154 1.000 16.14694 ? 262 LEU A CA  1 
ATOM   2130 C C   . LEU A 1 268 ? 17.76935  15.72294  65.15227 1.000 14.79356 ? 262 LEU A C   1 
ATOM   2131 O O   . LEU A 1 268 ? 17.18703  16.10079  66.18656 1.000 17.04142 ? 262 LEU A O   1 
ATOM   2132 C CB  . LEU A 1 268 ? 16.57698  14.11988  63.62046 1.000 17.09042 ? 262 LEU A CB  1 
ATOM   2133 C CG  . LEU A 1 268 ? 15.63342  13.97461  62.43553 1.000 18.83375 ? 262 LEU A CG  1 
ATOM   2134 C CD1 . LEU A 1 268 ? 15.49572  12.50344  62.09175 1.000 19.38017 ? 262 LEU A CD1 1 
ATOM   2135 C CD2 . LEU A 1 268 ? 14.25465  14.64325  62.68870 1.000 20.98823 ? 262 LEU A CD2 1 
ATOM   2136 N N   . LEU A 1 269 ? 19.08962  15.42030  65.14017 1.000 15.49776 ? 263 LEU A N   1 
ATOM   2137 C CA  . LEU A 1 269 ? 19.84899  15.50283  66.38149 1.000 16.85859 ? 263 LEU A CA  1 
ATOM   2138 C C   . LEU A 1 269 ? 20.00392  16.94106  66.86351 1.000 18.60839 ? 263 LEU A C   1 
ATOM   2139 O O   . LEU A 1 269 ? 20.24034  17.15660  68.06865 1.000 19.88263 ? 263 LEU A O   1 
ATOM   2140 C CB  . LEU A 1 269 ? 21.25654  14.88323  66.20021 1.000 17.25068 ? 263 LEU A CB  1 
ATOM   2141 C CG  . LEU A 1 269 ? 21.22957  13.36118  66.10247 1.000 17.85378 ? 263 LEU A CG  1 
ATOM   2142 C CD1 . LEU A 1 269 ? 22.61206  12.90539  65.67590 1.000 21.23963 ? 263 LEU A CD1 1 
ATOM   2143 C CD2 . LEU A 1 269 ? 20.89014  12.74912  67.48304 1.000 18.85938 ? 263 LEU A CD2 1 
ATOM   2144 N N   . SER A 1 270 ? 19.85513  17.92058  65.94294 1.000 17.40481 ? 264 SER A N   1 
ATOM   2145 C CA  . SER A 1 270 ? 20.01416  19.32585  66.28152 1.000 18.18985 ? 264 SER A CA  1 
ATOM   2146 C C   . SER A 1 270 ? 18.80391  19.91083  67.01335 1.000 18.01161 ? 264 SER A C   1 
ATOM   2147 O O   . SER A 1 270 ? 18.89629  21.03371  67.56243 1.000 20.50317 ? 264 SER A O   1 
ATOM   2148 C CB  . SER A 1 270 ? 20.25043  20.15307  65.01477 1.000 19.80752 ? 264 SER A CB  1 
ATOM   2149 O OG  . SER A 1 270 ? 19.04182  20.35980  64.26790 1.000 21.19563 ? 264 SER A OG  1 
ATOM   2150 N N   . LEU A 1 271 ? 17.68364  19.20168  67.03047 1.000 17.52848 ? 265 LEU A N   1 
ATOM   2151 C CA  . LEU A 1 271 ? 16.44776  19.71324  67.61346 1.000 17.35320 ? 265 LEU A CA  1 
ATOM   2152 C C   . LEU A 1 271 ? 16.43366  19.49949  69.12359 1.000 17.70190 ? 265 LEU A C   1 
ATOM   2153 O O   . LEU A 1 271 ? 16.93121  18.48334  69.62835 1.000 19.54800 ? 265 LEU A O   1 
ATOM   2154 C CB  . LEU A 1 271 ? 15.23470  19.00527  66.98100 1.000 15.25216 ? 265 LEU A CB  1 
ATOM   2155 C CG  . LEU A 1 271 ? 15.10830  19.16366  65.44644 1.000 16.65178 ? 265 LEU A CG  1 
ATOM   2156 C CD1 . LEU A 1 271 ? 13.95985  18.31051  64.92332 1.000 18.06842 ? 265 LEU A CD1 1 
ATOM   2157 C CD2 . LEU A 1 271 ? 14.86152  20.67441  65.13369 1.000 19.73728 ? 265 LEU A CD2 1 
ATOM   2158 N N   . PRO A 1 272 ? 15.86735  20.42450  69.87585 1.000 18.64355 ? 266 PRO A N   1 
ATOM   2159 C CA  . PRO A 1 272 ? 15.60532  20.13862  71.29251 1.000 18.90941 ? 266 PRO A CA  1 
ATOM   2160 C C   . PRO A 1 272 ? 14.68524  18.93521  71.43468 1.000 19.40191 ? 266 PRO A C   1 
ATOM   2161 O O   . PRO A 1 272 ? 13.88879  18.63657  70.55394 1.000 21.52638 ? 266 PRO A O   1 
ATOM   2162 C CB  . PRO A 1 272 ? 14.95131  21.43235  71.82112 1.000 21.46111 ? 266 PRO A CB  1 
ATOM   2163 C CG  . PRO A 1 272 ? 14.98864  22.41768  70.66039 1.000 23.28602 ? 266 PRO A CG  1 
ATOM   2164 C CD  . PRO A 1 272 ? 15.32443  21.70347  69.39607 1.000 20.17603 ? 266 PRO A CD  1 
ATOM   2165 N N   . HIS A 1 273 ? 14.80164  18.25036  72.57438 1.000 20.61003 ? 267 HIS A N   1 
ATOM   2166 C CA  . HIS A 1 273 ? 13.90898  17.16854  72.90357 1.000 21.28637 ? 267 HIS A CA  1 
ATOM   2167 C C   . HIS A 1 273 ? 12.46396  17.65705  72.94251 1.000 21.44421 ? 267 HIS A C   1 
ATOM   2168 O O   . HIS A 1 273 ? 12.17375  18.70667  73.52442 1.000 23.78765 ? 267 HIS A O   1 
ATOM   2169 C CB  . HIS A 1 273 ? 14.33891  16.61031  74.28058 0.979 24.02466 ? 267 HIS A CB  1 
ATOM   2170 C CG  . HIS A 1 273 ? 13.48193  15.51071  74.78599 0.921 26.34699 ? 267 HIS A CG  1 
ATOM   2171 N ND1 . HIS A 1 273 ? 13.10128  14.42681  74.02444 0.706 24.96473 ? 267 HIS A ND1 1 
ATOM   2172 C CD2 . HIS A 1 273 ? 12.94844  15.31900  76.01057 0.626 28.70195 ? 267 HIS A CD2 1 
ATOM   2173 C CE1 . HIS A 1 273 ? 12.33365  13.63483  74.75928 1.000 26.47797 ? 267 HIS A CE1 1 
ATOM   2174 N NE2 . HIS A 1 273 ? 12.23466  14.15013  75.96738 0.387 28.43173 ? 267 HIS A NE2 1 
ATOM   2175 N N   . LYS A 1 274 ? 11.56649  16.87379  72.32993 1.000 20.78636 ? 268 LYS A N   1 
ATOM   2176 C CA  . LYS A 1 274 ? 10.12559  17.12734  72.28982 1.000 21.86197 ? 268 LYS A CA  1 
ATOM   2177 C C   . LYS A 1 274 ? 9.45362   15.87763  72.84531 1.000 23.95912 ? 268 LYS A C   1 
ATOM   2178 O O   . LYS A 1 274 ? 9.74990   14.76882  72.37852 1.000 23.19345 ? 268 LYS A O   1 
ATOM   2179 C CB  . LYS A 1 274 ? 9.65362   17.35341  70.83366 1.000 24.31375 ? 268 LYS A CB  1 
ATOM   2180 C CG  . LYS A 1 274 ? 10.32505  18.52146  70.12988 0.873 28.06107 ? 268 LYS A CG  1 
ATOM   2181 C CD  . LYS A 1 274 ? 9.74085   18.81251  68.74265 0.627 29.49725 ? 268 LYS A CD  1 
ATOM   2182 C CE  . LYS A 1 274 ? 10.87183  19.17873  67.75804 0.964 30.92230 ? 268 LYS A CE  1 
ATOM   2183 N NZ  . LYS A 1 274 ? 10.49520  20.47208  67.20143 0.779 30.99531 ? 268 LYS A NZ  1 
ATOM   2184 N N   . ASN A 1 275 ? 8.54504   16.03303  73.82549 1.000 27.12557 ? 269 ASN A N   1 
ATOM   2185 C CA  . ASN A 1 275 ? 7.79005   14.87984  74.30317 1.000 27.59079 ? 269 ASN A CA  1 
ATOM   2186 C C   . ASN A 1 275 ? 6.60440   14.56703  73.39611 1.000 26.74608 ? 269 ASN A C   1 
ATOM   2187 O O   . ASN A 1 275 ? 6.04925   15.43850  72.72026 1.000 29.50080 ? 269 ASN A O   1 
ATOM   2188 C CB  . ASN A 1 275 ? 7.23911   15.08090  75.71886 0.967 30.54140 ? 269 ASN A CB  1 
ATOM   2189 C CG  . ASN A 1 275 ? 8.22943   15.68015  76.62972 0.723 31.97762 ? 269 ASN A CG  1 
ATOM   2190 O OD1 . ASN A 1 275 ? 8.09150   16.83239  77.01682 0.394 33.08333 ? 269 ASN A OD1 1 
ATOM   2191 N ND2 . ASN A 1 275 ? 9.24774   14.91338  76.98518 0.570 34.11543 ? 269 ASN A ND2 1 
ATOM   2192 N N   . LYS A 1 276 ? 6.24219   13.29291  73.37761 1.000 25.55883 ? 270 LYS A N   1 
ATOM   2193 C CA  . LYS A 1 276 ? 5.03855   12.85096  72.69733 1.000 22.85935 ? 270 LYS A CA  1 
ATOM   2194 C C   . LYS A 1 276 ? 3.80431   13.47127  73.34907 1.000 23.77512 ? 270 LYS A C   1 
ATOM   2195 O O   . LYS A 1 276 ? 3.74132   13.63789  74.56827 1.000 26.42309 ? 270 LYS A O   1 
ATOM   2196 C CB  . LYS A 1 276 ? 4.95361   11.30882  72.73462 1.000 25.69829 ? 270 LYS A CB  1 
ATOM   2197 C CG  . LYS A 1 276 ? 3.75767   10.69696  71.96439 1.000 29.29147 ? 270 LYS A CG  1 
ATOM   2198 C CD  . LYS A 1 276 ? 3.75191   9.15044   72.09911 1.000 33.12506 ? 270 LYS A CD  1 
ATOM   2199 C CE  . LYS A 1 276 ? 2.73174   8.43408   71.12526 1.000 35.00964 ? 270 LYS A CE  1 
ATOM   2200 N NZ  . LYS A 1 276 ? 2.88960   8.81515   69.66039 1.000 35.89631 ? 270 LYS A NZ  1 
ATOM   2201 N N   . VAL A 1 277 ? 2.84571   13.86253  72.52493 1.000 23.25046 ? 271 VAL A N   1 
ATOM   2202 C CA  . VAL A 1 277 ? 1.52653   14.28453  72.99098 1.000 23.07535 ? 271 VAL A CA  1 
ATOM   2203 C C   . VAL A 1 277 ? 0.62960   13.05024  72.96585 1.000 22.47529 ? 271 VAL A C   1 
ATOM   2204 O O   . VAL A 1 277 ? 0.43049   12.48099  71.89700 1.000 22.90422 ? 271 VAL A O   1 
ATOM   2205 C CB  . VAL A 1 277 ? 0.92432   15.38322  72.09672 1.000 25.20278 ? 271 VAL A CB  1 
ATOM   2206 C CG1 . VAL A 1 277 ? -0.50096  15.70347  72.56214 1.000 26.87901 ? 271 VAL A CG1 1 
ATOM   2207 C CG2 . VAL A 1 277 ? 1.77828   16.65888  71.99599 1.000 27.07053 ? 271 VAL A CG2 1 
ATOM   2208 N N   . PRO A 1 278 ? 0.04952   12.63271  74.08257 1.000 24.59126 ? 272 PRO A N   1 
ATOM   2209 C CA  . PRO A 1 278 ? -0.78701  11.42332  74.05970 1.000 24.40594 ? 272 PRO A CA  1 
ATOM   2210 C C   . PRO A 1 278 ? -1.99239  11.59000  73.15686 1.000 23.18212 ? 272 PRO A C   1 
ATOM   2211 O O   . PRO A 1 278 ? -2.66863  12.62900  73.16421 1.000 23.93588 ? 272 PRO A O   1 
ATOM   2212 C CB  . PRO A 1 278 ? -1.21767  11.24286  75.52585 1.000 25.15301 ? 272 PRO A CB  1 
ATOM   2213 C CG  . PRO A 1 278 ? -0.20130  12.01577  76.30744 1.000 26.58254 ? 272 PRO A CG  1 
ATOM   2214 C CD  . PRO A 1 278 ? 0.22948   13.16816  75.43782 1.000 25.40694 ? 272 PRO A CD  1 
ATOM   2215 N N   . TRP A 1 279 ? -2.29101  10.52957  72.41484 1.000 21.56936 ? 273 TRP A N   1 
ATOM   2216 C CA  . TRP A 1 279 ? -3.42535  10.58513  71.49279 1.000 21.53453 ? 273 TRP A CA  1 
ATOM   2217 C C   . TRP A 1 279 ? -4.71800  10.89862  72.23496 1.000 24.11572 ? 273 TRP A C   1 
ATOM   2218 O O   . TRP A 1 279 ? -5.55942  11.63009  71.72185 1.000 24.61512 ? 273 TRP A O   1 
ATOM   2219 C CB  . TRP A 1 279 ? -3.57038  9.25673   70.74009 1.000 21.60093 ? 273 TRP A CB  1 
ATOM   2220 C CG  . TRP A 1 279 ? -2.38178  8.94239   69.87720 1.000 20.24295 ? 273 TRP A CG  1 
ATOM   2221 C CD1 . TRP A 1 279 ? -1.54076  7.89530   70.02768 1.000 20.87319 ? 273 TRP A CD1 1 
ATOM   2222 C CD2 . TRP A 1 279 ? -1.93171  9.66865   68.73362 1.000 20.67705 ? 273 TRP A CD2 1 
ATOM   2223 N NE1 . TRP A 1 279 ? -0.56840  7.91619   69.05112 1.000 22.41238 ? 273 TRP A NE1 1 
ATOM   2224 C CE2 . TRP A 1 279 ? -0.79284  8.99360   68.23055 1.000 21.18849 ? 273 TRP A CE2 1 
ATOM   2225 C CE3 . TRP A 1 279 ? -2.35645  10.82897  68.09406 1.000 22.60986 ? 273 TRP A CE3 1 
ATOM   2226 C CZ2 . TRP A 1 279 ? -0.07521  9.44966   67.12543 1.000 21.80978 ? 273 TRP A CZ2 1 
ATOM   2227 C CZ3 . TRP A 1 279 ? -1.62619  11.28047  66.96165 1.000 23.90304 ? 273 TRP A CZ3 1 
ATOM   2228 C CH2 . TRP A 1 279 ? -0.51907  10.58766  66.49842 1.000 22.70283 ? 273 TRP A CH2 1 
ATOM   2229 N N   . ASN A 1 280 ? -4.89481  10.35891  73.44572 1.000 26.36994 ? 274 ASN A N   1 
ATOM   2230 C CA  . ASN A 1 280 ? -6.16928  10.58997  74.11783 1.000 28.01209 ? 274 ASN A CA  1 
ATOM   2231 C C   . ASN A 1 280 ? -6.26490  11.97444  74.75054 1.000 28.28627 ? 274 ASN A C   1 
ATOM   2232 O O   . ASN A 1 280 ? -7.36250  12.36454  75.15935 1.000 28.76484 ? 274 ASN A O   1 
ATOM   2233 C CB  . ASN A 1 280 ? -6.44831  9.48779   75.15228 0.939 31.13724 ? 274 ASN A CB  1 
ATOM   2234 C CG  . ASN A 1 280 ? -5.58686  9.59111   76.37853 1.000 32.63681 ? 274 ASN A CG  1 
ATOM   2235 O OD1 . ASN A 1 280 ? -4.53952  10.21996  76.37188 0.702 32.04690 ? 274 ASN A OD1 1 
ATOM   2236 N ND2 . ASN A 1 280 ? -6.03510  8.96189   77.45235 0.758 33.89865 ? 274 ASN A ND2 1 
ATOM   2237 N N   . ARG A 1 281 ? -5.16868  12.73764  74.80217 1.000 27.22812 ? 275 ARG A N   1 
ATOM   2238 C CA  . ARG A 1 281 ? -5.24892  14.16657  75.10988 1.000 29.28298 ? 275 ARG A CA  1 
ATOM   2239 C C   . ARG A 1 281 ? -5.65769  14.97559  73.87800 1.000 28.73573 ? 275 ARG A C   1 
ATOM   2240 O O   . ARG A 1 281 ? -6.46590  15.91266  73.98038 1.000 32.34464 ? 275 ARG A O   1 
ATOM   2241 C CB  . ARG A 1 281 ? -3.89796  14.65585  75.64039 1.000 30.42792 ? 275 ARG A CB  1 
ATOM   2242 C CG  . ARG A 1 281 ? -3.89037  15.94518  76.41326 0.644 33.57186 ? 275 ARG A CG  1 
ATOM   2243 C CD  . ARG A 1 281 ? -2.46819  16.45689  76.49247 0.529 36.68198 ? 275 ARG A CD  1 
ATOM   2244 N NE  . ARG A 1 281 ? -1.76683  15.86533  77.61952 0.464 38.92245 ? 275 ARG A NE  1 
ATOM   2245 C CZ  . ARG A 1 281 ? -0.46055  15.95360  77.82661 0.789 40.70161 ? 275 ARG A CZ  1 
ATOM   2246 N NH1 . ARG A 1 281 ? 0.32995   16.64186  77.01123 0.910 42.69461 ? 275 ARG A NH1 1 
ATOM   2247 N NH2 . ARG A 1 281 ? 0.07159   15.29288  78.84713 0.742 41.11139 ? 275 ARG A NH2 1 
ATOM   2248 N N   . LEU A 1 282 ? -5.09654  14.62589  72.71546 1.000 29.15539 ? 276 LEU A N   1 
ATOM   2249 C CA  . LEU A 1 282 ? -5.44024  15.24945  71.44340 1.000 29.14756 ? 276 LEU A CA  1 
ATOM   2250 C C   . LEU A 1 282 ? -6.86869  14.95100  71.05684 1.000 30.32396 ? 276 LEU A C   1 
ATOM   2251 O O   . LEU A 1 282 ? -7.52025  15.77918  70.42240 1.000 32.43884 ? 276 LEU A O   1 
ATOM   2252 C CB  . LEU A 1 282 ? -4.48668  14.70978  70.37093 1.000 32.20239 ? 276 LEU A CB  1 
ATOM   2253 C CG  . LEU A 1 282 ? -3.17682  15.40967  70.08751 1.000 35.71976 ? 276 LEU A CG  1 
ATOM   2254 C CD1 . LEU A 1 282 ? -2.71020  15.00214  68.67818 1.000 37.56420 ? 276 LEU A CD1 1 
ATOM   2255 C CD2 . LEU A 1 282 ? -3.43867  16.90433  70.09161 1.000 36.27321 ? 276 LEU A CD2 1 
ATOM   2256 N N   . PHE A 1 283 ? -7.34818  13.74185  71.36854 1.000 27.63789 ? 277 PHE A N   1 
ATOM   2257 C CA  . PHE A 1 283 ? -8.65383  13.25046  70.90827 1.000 25.32582 ? 277 PHE A CA  1 
ATOM   2258 C C   . PHE A 1 283 ? -9.39960  12.63859  72.08825 1.000 26.38625 ? 277 PHE A C   1 
ATOM   2259 O O   . PHE A 1 283 ? -9.53743  11.41403  72.19341 1.000 26.20279 ? 277 PHE A O   1 
ATOM   2260 C CB  . PHE A 1 283 ? -8.48020  12.22337  69.79021 1.000 24.33873 ? 277 PHE A CB  1 
ATOM   2261 C CG  . PHE A 1 283 ? -7.68895  12.72796  68.60074 1.000 24.82688 ? 277 PHE A CG  1 
ATOM   2262 C CD1 . PHE A 1 283 ? -8.20574  13.70498  67.75534 1.000 25.94289 ? 277 PHE A CD1 1 
ATOM   2263 C CD2 . PHE A 1 283 ? -6.43760  12.23868  68.33862 1.000 25.39081 ? 277 PHE A CD2 1 
ATOM   2264 C CE1 . PHE A 1 283 ? -7.46917  14.13809  66.63961 1.000 25.93326 ? 277 PHE A CE1 1 
ATOM   2265 C CE2 . PHE A 1 283 ? -5.70286  12.67417  67.24086 1.000 25.00924 ? 277 PHE A CE2 1 
ATOM   2266 C CZ  . PHE A 1 283 ? -6.19884  13.62026  66.40339 1.000 24.97560 ? 277 PHE A CZ  1 
ATOM   2267 N N   . PRO A 1 284 ? -9.89962  13.46864  72.99876 1.000 30.52579 ? 278 PRO A N   1 
ATOM   2268 C CA  . PRO A 1 284 ? -10.43051 12.93427  74.27218 1.000 32.38236 ? 278 PRO A CA  1 
ATOM   2269 C C   . PRO A 1 284 ? -11.75894 12.18233  74.13582 1.000 34.99368 ? 278 PRO A C   1 
ATOM   2270 O O   . PRO A 1 284 ? -12.09939 11.38617  75.02094 1.000 36.24246 ? 278 PRO A O   1 
ATOM   2271 C CB  . PRO A 1 284 ? -10.59562 14.19605  75.13674 1.000 32.55440 ? 278 PRO A CB  1 
ATOM   2272 C CG  . PRO A 1 284 ? -10.74603 15.33427  74.13410 1.000 32.41369 ? 278 PRO A CG  1 
ATOM   2273 C CD  . PRO A 1 284 ? -9.86811  14.93828  72.95097 1.000 31.12086 ? 278 PRO A CD  1 
ATOM   2274 N N   . ASN A 1 285 ? -12.49796 12.38541  73.04692 1.000 33.59596 ? 279 ASN A N   1 
ATOM   2275 C CA  . ASN A 1 285 ? -13.75518 11.68574  72.76444 1.000 33.93938 ? 279 ASN A CA  1 
ATOM   2276 C C   . ASN A 1 285 ? -13.56864 10.43871  71.88703 1.000 30.63372 ? 279 ASN A C   1 
ATOM   2277 O O   . ASN A 1 285 ? -14.55398 9.70665   71.63150 1.000 32.40222 ? 279 ASN A O   1 
ATOM   2278 C CB  . ASN A 1 285 ? -14.74092 12.64097  72.05539 0.865 36.23073 ? 279 ASN A CB  1 
ATOM   2279 C CG  . ASN A 1 285 ? -14.72098 14.04053  72.63877 0.458 38.96720 ? 279 ASN A CG  1 
ATOM   2280 O OD1 . ASN A 1 285 ? -14.53179 14.21823  73.83802 0.459 39.79950 ? 279 ASN A OD1 1 
ATOM   2281 N ND2 . ASN A 1 285 ? -14.90076 15.04353  71.78596 0.543 40.10155 ? 279 ASN A ND2 1 
ATOM   2282 N N   . ALA A 1 286 ? -12.34599 10.17216  71.41109 1.000 26.75093 ? 280 ALA A N   1 
ATOM   2283 C CA  . ALA A 1 286 ? -12.16537 9.09203   70.46079 1.000 24.19009 ? 280 ALA A CA  1 
ATOM   2284 C C   . ALA A 1 286 ? -12.23959 7.73330   71.14537 1.000 24.64627 ? 280 ALA A C   1 
ATOM   2285 O O   . ALA A 1 286 ? -11.89034 7.58212   72.32419 1.000 26.09671 ? 280 ALA A O   1 
ATOM   2286 C CB  . ALA A 1 286 ? -10.81423 9.22423   69.74720 1.000 23.23208 ? 280 ALA A CB  1 
ATOM   2287 N N   . ASP A 1 287 ? -12.68889 6.74271   70.37274 1.000 23.47654 ? 281 ASP A N   1 
ATOM   2288 C CA  . ASP A 1 287 ? -12.64460 5.34075   70.77839 1.000 23.36627 ? 281 ASP A CA  1 
ATOM   2289 C C   . ASP A 1 287 ? -11.19042 4.93688   71.05782 1.000 22.89188 ? 281 ASP A C   1 
ATOM   2290 O O   . ASP A 1 287 ? -10.28785 5.25461   70.26979 1.000 22.93734 ? 281 ASP A O   1 
ATOM   2291 C CB  . ASP A 1 287 ? -13.25290 4.50045   69.65756 1.000 24.35629 ? 281 ASP A CB  1 
ATOM   2292 C CG  . ASP A 1 287 ? -13.29179 3.03890   69.96147 1.000 26.80397 ? 281 ASP A CG  1 
ATOM   2293 O OD1 . ASP A 1 287 ? -12.27148 2.37467   69.92534 0.608 27.39537 ? 281 ASP A OD1 1 
ATOM   2294 O OD2 . ASP A 1 287 ? -14.40613 2.53251   70.15394 0.514 27.08484 ? 281 ASP A OD2 1 
ATOM   2295 N N   . SER A 1 288 ? -10.94815 4.25955   72.19714 1.000 24.27940 ? 282 SER A N   1 
ATOM   2296 C CA  . SER A 1 288 ? -9.56710  3.88915   72.53611 1.000 22.91707 ? 282 SER A CA  1 
ATOM   2297 C C   . SER A 1 288 ? -8.95161  2.93830   71.50633 1.000 21.85826 ? 282 SER A C   1 
ATOM   2298 O O   . SER A 1 288 ? -7.73758  2.98706   71.25272 1.000 21.43094 ? 282 SER A O   1 
ATOM   2299 C CB  . SER A 1 288 ? -9.50672  3.25701   73.93367 1.000 26.47939 ? 282 SER A CB  1 
ATOM   2300 O OG  . SER A 1 288 ? -10.29787 2.08067   73.95960 1.000 28.26602 ? 282 SER A OG  1 
ATOM   2301 N N   . LYS A 1 289 ? -9.75893  2.06693   70.89980 1.000 22.00864 ? 283 LYS A N   1 
ATOM   2302 C CA  . LYS A 1 289 ? -9.22025  1.17574   69.87293 1.000 20.59960 ? 283 LYS A CA  1 
ATOM   2303 C C   . LYS A 1 289 ? -8.85040  1.95096   68.62525 1.000 18.72333 ? 283 LYS A C   1 
ATOM   2304 O O   . LYS A 1 289 ? -7.82083  1.65481   67.98757 1.000 19.36353 ? 283 LYS A O   1 
ATOM   2305 C CB  . LYS A 1 289 ? -10.22489 0.07416   69.53625 1.000 21.74626 ? 283 LYS A CB  1 
ATOM   2306 C CG  . LYS A 1 289 ? -10.56188 -0.80489  70.70983 1.000 24.07592 ? 283 LYS A CG  1 
ATOM   2307 C CD  . LYS A 1 289 ? -11.57805 -1.89652  70.32940 1.000 26.07365 ? 283 LYS A CD  1 
ATOM   2308 C CE  . LYS A 1 289 ? -11.97017 -2.66264  71.59206 0.897 29.16138 ? 283 LYS A CE  1 
ATOM   2309 N NZ  . LYS A 1 289 ? -12.87420 -3.81835  71.32269 0.592 30.68496 ? 283 LYS A NZ  1 
ATOM   2310 N N   . ALA A 1 290 ? -9.65572  2.96635   68.27573 1.000 18.80716 ? 284 ALA A N   1 
ATOM   2311 C CA  . ALA A 1 290 ? -9.29089  3.82412   67.14501 1.000 18.11712 ? 284 ALA A CA  1 
ATOM   2312 C C   . ALA A 1 290 ? -7.93199  4.49914   67.37680 1.000 18.52665 ? 284 ALA A C   1 
ATOM   2313 O O   . ALA A 1 290 ? -7.12335  4.62252   66.43917 1.000 17.52153 ? 284 ALA A O   1 
ATOM   2314 C CB  . ALA A 1 290 ? -10.37945 4.86189   66.87422 1.000 18.92443 ? 284 ALA A CB  1 
ATOM   2315 N N   . LEU A 1 291 ? -7.66561  4.94788   68.61489 1.000 17.90417 ? 285 LEU A N   1 
ATOM   2316 C CA  . LEU A 1 291 ? -6.40838  5.63362   68.89109 1.000 17.33899 ? 285 LEU A CA  1 
ATOM   2317 C C   . LEU A 1 291 ? -5.24250  4.66840   68.87955 1.000 17.50268 ? 285 LEU A C   1 
ATOM   2318 O O   . LEU A 1 291 ? -4.11011  5.06270   68.55928 1.000 18.41638 ? 285 LEU A O   1 
ATOM   2319 C CB  . LEU A 1 291 ? -6.48070  6.36635   70.24040 1.000 17.80797 ? 285 LEU A CB  1 
ATOM   2320 C CG  . LEU A 1 291 ? -7.53653  7.49589   70.27873 1.000 18.14138 ? 285 LEU A CG  1 
ATOM   2321 C CD1 . LEU A 1 291 ? -7.47474  8.25273   71.60221 1.000 19.73225 ? 285 LEU A CD1 1 
ATOM   2322 C CD2 . LEU A 1 291 ? -7.36970  8.45179   69.11829 1.000 18.65843 ? 285 LEU A CD2 1 
ATOM   2323 N N   . ASP A 1 292 ? -5.46934  3.42478   69.27130 1.000 17.48874 ? 286 ASP A N   1 
ATOM   2324 C CA  . ASP A 1 292 ? -4.39021  2.44956   69.18619 1.000 18.49186 ? 286 ASP A CA  1 
ATOM   2325 C C   . ASP A 1 292 ? -4.00208  2.20438   67.72855 1.000 18.21742 ? 286 ASP A C   1 
ATOM   2326 O O   . ASP A 1 292 ? -2.80933  2.16071   67.38816 1.000 19.07329 ? 286 ASP A O   1 
ATOM   2327 C CB  . ASP A 1 292 ? -4.82442  1.14311   69.84913 1.000 21.46726 ? 286 ASP A CB  1 
ATOM   2328 C CG  . ASP A 1 292 ? -3.69370  0.17857   69.95744 1.000 23.21192 ? 286 ASP A CG  1 
ATOM   2329 O OD1 . ASP A 1 292 ? -2.88544  0.30805   70.91527 1.000 26.73493 ? 286 ASP A OD1 1 
ATOM   2330 O OD2 . ASP A 1 292 ? -3.59710  -0.70272  69.07828 1.000 22.84769 ? 286 ASP A OD2 1 
ATOM   2331 N N   . LEU A 1 293 ? -5.00179  2.08272   66.85170 1.000 17.47429 ? 287 LEU A N   1 
ATOM   2332 C CA  . LEU A 1 293 ? -4.71196  1.91211   65.42998 1.000 16.49018 ? 287 LEU A CA  1 
ATOM   2333 C C   . LEU A 1 293 ? -4.06640  3.17083   64.86152 1.000 16.24197 ? 287 LEU A C   1 
ATOM   2334 O O   . LEU A 1 293 ? -3.10068  3.07945   64.08456 1.000 16.44498 ? 287 LEU A O   1 
ATOM   2335 C CB  . LEU A 1 293 ? -5.98217  1.54698   64.68865 1.000 16.63444 ? 287 LEU A CB  1 
ATOM   2336 C CG  . LEU A 1 293 ? -5.84986  1.30664   63.17846 1.000 14.97379 ? 287 LEU A CG  1 
ATOM   2337 C CD1 . LEU A 1 293 ? -4.72030  0.33846   62.85186 1.000 15.55241 ? 287 LEU A CD1 1 
ATOM   2338 C CD2 . LEU A 1 293 ? -7.16471  0.78977   62.58171 1.000 16.39341 ? 287 LEU A CD2 1 
ATOM   2339 N N   . LEU A 1 294 ? -4.54859  4.35624   65.26648 1.000 15.81480 ? 288 LEU A N   1 
ATOM   2340 C CA  . LEU A 1 294 ? -3.95180  5.60897   64.80925 1.000 15.22854 ? 288 LEU A CA  1 
ATOM   2341 C C   . LEU A 1 294 ? -2.46819  5.64500   65.14560 1.000 15.85447 ? 288 LEU A C   1 
ATOM   2342 O O   . LEU A 1 294 ? -1.62880  6.00661   64.31028 1.000 15.68419 ? 288 LEU A O   1 
ATOM   2343 C CB  . LEU A 1 294 ? -4.67032  6.79244   65.47456 1.000 13.71287 ? 288 LEU A CB  1 
ATOM   2344 C CG  . LEU A 1 294 ? -4.13647  8.19926   65.07667 1.000 14.21115 ? 288 LEU A CG  1 
ATOM   2345 C CD1 . LEU A 1 294 ? -4.36251  8.47909   63.55632 1.000 14.63579 ? 288 LEU A CD1 1 
ATOM   2346 C CD2 . LEU A 1 294 ? -4.78181  9.30678   65.95337 1.000 16.60282 ? 288 LEU A CD2 1 
ATOM   2347 N N   . ASP A 1 295 ? -2.12672  5.21984   66.36568 1.000 16.38331 ? 289 ASP A N   1 
ATOM   2348 C CA  . ASP A 1 295 ? -0.74718  5.24506   66.80483 1.000 16.82480 ? 289 ASP A CA  1 
ATOM   2349 C C   . ASP A 1 295 ? 0.11567   4.36810   65.91606 1.000 16.57706 ? 289 ASP A C   1 
ATOM   2350 O O   . ASP A 1 295 ? 1.24010   4.74307   65.56809 1.000 17.15418 ? 289 ASP A O   1 
ATOM   2351 C CB  . ASP A 1 295 ? -0.66470  4.75935   68.26442 1.000 19.91200 ? 289 ASP A CB  1 
ATOM   2352 C CG  . ASP A 1 295 ? 0.76603   4.74926   68.74742 1.000 23.16769 ? 289 ASP A CG  1 
ATOM   2353 O OD1 . ASP A 1 295 ? 1.29824   5.86516   68.91178 1.000 24.11241 ? 289 ASP A OD1 1 
ATOM   2354 O OD2 . ASP A 1 295 ? 1.38391   3.65093   68.86413 1.000 25.54593 ? 289 ASP A OD2 1 
ATOM   2355 N N   . LYS A 1 296 ? -0.40591  3.20714   65.52634 1.000 16.64083 ? 290 LYS A N   1 
ATOM   2356 C CA  . LYS A 1 296 ? 0.36590   2.28001   64.70352 1.000 15.30479 ? 290 LYS A CA  1 
ATOM   2357 C C   . LYS A 1 296 ? 0.48869   2.77592   63.25913 1.000 17.01893 ? 290 LYS A C   1 
ATOM   2358 O O   . LYS A 1 296 ? 1.48553   2.48929   62.58854 1.000 18.33249 ? 290 LYS A O   1 
ATOM   2359 C CB  . LYS A 1 296 ? -0.29025  0.90768   64.75073 1.000 16.16366 ? 290 LYS A CB  1 
ATOM   2360 C CG  . LYS A 1 296 ? -0.14659  0.28730   66.13613 1.000 18.30074 ? 290 LYS A CG  1 
ATOM   2361 C CD  A LYS A 1 296 ? -0.96145  -1.01353  66.20983 0.820 21.05537 ? 290 LYS A CD  1 
ATOM   2362 C CD  B LYS A 1 296 ? -1.03946  -0.93605  66.25918 0.180 18.70755 ? 290 LYS A CD  1 
ATOM   2363 C CE  A LYS A 1 296 ? -0.59227  -1.88996  67.40533 0.820 23.81665 ? 290 LYS A CE  1 
ATOM   2364 C CE  B LYS A 1 296 ? -0.80133  -1.68124  67.55910 0.180 18.89173 ? 290 LYS A CE  1 
ATOM   2365 N NZ  A LYS A 1 296 ? -0.73450  -1.20172  68.70606 0.820 25.27519 ? 290 LYS A NZ  1 
ATOM   2366 N NZ  B LYS A 1 296 ? -1.78889  -2.77900  67.75610 0.180 18.97568 ? 290 LYS A NZ  1 
ATOM   2367 N N   . MET A 1 297 ? -0.49328  3.52796   62.77126 1.000 15.11233 ? 291 MET A N   1 
ATOM   2368 C CA  . MET A 1 297 ? -0.38041  4.10254   61.41519 1.000 14.31738 ? 291 MET A CA  1 
ATOM   2369 C C   . MET A 1 297 ? 0.54039   5.31428   61.37707 1.000 14.77204 ? 291 MET A C   1 
ATOM   2370 O O   . MET A 1 297 ? 1.24362   5.53704   60.37249 1.000 16.24247 ? 291 MET A O   1 
ATOM   2371 C CB  A MET A 1 297 ? -1.77829  4.47412   60.88733 0.537 13.35410 ? 291 MET A CB  1 
ATOM   2372 C CB  B MET A 1 297 ? -1.76879  4.50531   60.90193 0.463 14.10230 ? 291 MET A CB  1 
ATOM   2373 C CG  A MET A 1 297 ? -2.56755  3.23372   60.47345 0.537 14.44886 ? 291 MET A CG  1 
ATOM   2374 C CG  B MET A 1 297 ? -2.75321  3.35856   60.85703 0.463 15.37416 ? 291 MET A CG  1 
ATOM   2375 S SD  A MET A 1 297 ? -4.12528  3.53504   59.61590 0.537 15.89848 ? 291 MET A SD  1 
ATOM   2376 S SD  B MET A 1 297 ? -4.32658  3.98772   60.30471 0.463 16.89902 ? 291 MET A SD  1 
ATOM   2377 C CE  A MET A 1 297 ? -4.98813  4.55802   60.78686 0.537 17.66312 ? 291 MET A CE  1 
ATOM   2378 C CE  B MET A 1 297 ? -5.02040  2.57589   59.46387 0.463 17.24969 ? 291 MET A CE  1 
ATOM   2379 N N   . LEU A 1 298 ? 0.51844   6.11769   62.43132 1.000 14.51852 ? 292 LEU A N   1 
ATOM   2380 C CA  . LEU A 1 298 ? 1.37807   7.29066   62.52240 1.000 14.38864 ? 292 LEU A CA  1 
ATOM   2381 C C   . LEU A 1 298 ? 2.63836   6.97522   63.31949 1.000 16.58334 ? 292 LEU A C   1 
ATOM   2382 O O   . LEU A 1 298 ? 3.03545   7.67699   64.23700 1.000 21.28420 ? 292 LEU A O   1 
ATOM   2383 C CB  . LEU A 1 298 ? 0.59689   8.47649   63.10744 1.000 14.36619 ? 292 LEU A CB  1 
ATOM   2384 C CG  . LEU A 1 298 ? -0.58912  8.94402   62.27253 1.000 14.86787 ? 292 LEU A CG  1 
ATOM   2385 C CD1 . LEU A 1 298 ? -1.24312  10.14757  62.92307 1.000 17.75181 ? 292 LEU A CD1 1 
ATOM   2386 C CD2 . LEU A 1 298 ? -0.13723  9.28757   60.84143 1.000 15.97215 ? 292 LEU A CD2 1 
ATOM   2387 N N   . THR A 1 299 ? 3.28119   5.86927   62.96419 1.000 16.54309 ? 293 THR A N   1 
ATOM   2388 C CA  . THR A 1 299 ? 4.55519   5.50113   63.54176 1.000 17.36070 ? 293 THR A CA  1 
ATOM   2389 C C   . THR A 1 299 ? 5.66335   6.17210   62.73513 1.000 16.12912 ? 293 THR A C   1 
ATOM   2390 O O   . THR A 1 299 ? 5.62514   6.17801   61.49491 1.000 17.21694 ? 293 THR A O   1 
ATOM   2391 C CB  . THR A 1 299 ? 4.65286   3.97191   63.54244 1.000 20.94321 ? 293 THR A CB  1 
ATOM   2392 O OG1 . THR A 1 299 ? 3.76592   3.47642   64.55149 1.000 23.61794 ? 293 THR A OG1 1 
ATOM   2393 C CG2 . THR A 1 299 ? 6.05121   3.46209   63.82668 1.000 23.16027 ? 293 THR A CG2 1 
ATOM   2394 N N   . PHE A 1 300 ? 6.62067   6.79518   63.43754 1.000 16.73258 ? 294 PHE A N   1 
ATOM   2395 C CA  . PHE A 1 300 ? 7.67703   7.56388   62.75593 1.000 18.55444 ? 294 PHE A CA  1 
ATOM   2396 C C   . PHE A 1 300 ? 8.51230   6.68653   61.82383 1.000 19.16709 ? 294 PHE A C   1 
ATOM   2397 O O   . PHE A 1 300 ? 8.74077   7.03534   60.66004 1.000 19.69883 ? 294 PHE A O   1 
ATOM   2398 C CB  . PHE A 1 300 ? 8.57189   8.23059   63.79970 1.000 19.31141 ? 294 PHE A CB  1 
ATOM   2399 C CG  . PHE A 1 300 ? 9.74417   8.96268   63.21590 1.000 20.68962 ? 294 PHE A CG  1 
ATOM   2400 C CD1 . PHE A 1 300 ? 9.63233   10.27707  62.78517 1.000 22.03379 ? 294 PHE A CD1 1 
ATOM   2401 C CD2 . PHE A 1 300 ? 10.98231  8.32985   63.11129 1.000 21.09208 ? 294 PHE A CD2 1 
ATOM   2402 C CE1 . PHE A 1 300 ? 10.76733  10.95384  62.22919 1.000 23.13349 ? 294 PHE A CE1 1 
ATOM   2403 C CE2 . PHE A 1 300 ? 12.09767  8.99887   62.55485 1.000 22.32058 ? 294 PHE A CE2 1 
ATOM   2404 C CZ  . PHE A 1 300 ? 11.98039  10.30306  62.12718 1.000 23.08509 ? 294 PHE A CZ  1 
ATOM   2405 N N   . ASN A 1 301 ? 8.98520   5.55503   62.31678 1.000 18.84416 ? 295 ASN A N   1 
ATOM   2406 C CA  . ASN A 1 301 ? 9.84281   4.63874   61.55100 1.000 18.19310 ? 295 ASN A CA  1 
ATOM   2407 C C   . ASN A 1 301 ? 8.97425   3.88122   60.54850 1.000 17.77114 ? 295 ASN A C   1 
ATOM   2408 O O   . ASN A 1 301 ? 8.11699   3.09772   60.97183 1.000 18.15999 ? 295 ASN A O   1 
ATOM   2409 C CB  . ASN A 1 301 ? 10.51806  3.66035   62.51454 1.000 19.79038 ? 295 ASN A CB  1 
ATOM   2410 C CG  . ASN A 1 301 ? 11.54222  2.77713   61.83630 1.000 22.50524 ? 295 ASN A CG  1 
ATOM   2411 O OD1 . ASN A 1 301 ? 11.43454  2.46898   60.65222 1.000 25.03765 ? 295 ASN A OD1 1 
ATOM   2412 N ND2 . ASN A 1 301 ? 12.51859  2.31450   62.60877 1.000 23.11465 ? 295 ASN A ND2 1 
ATOM   2413 N N   . PRO A 1 302 ? 9.15859   4.07987   59.23333 1.000 16.93775 ? 296 PRO A N   1 
ATOM   2414 C CA  . PRO A 1 302 ? 8.27537   3.41864   58.25435 1.000 17.82498 ? 296 PRO A CA  1 
ATOM   2415 C C   . PRO A 1 302 ? 8.38948   1.90530   58.27551 1.000 18.32775 ? 296 PRO A C   1 
ATOM   2416 O O   . PRO A 1 302 ? 7.40661   1.21632   57.96231 1.000 21.13582 ? 296 PRO A O   1 
ATOM   2417 C CB  . PRO A 1 302 ? 8.72561   4.01495   56.89501 1.000 17.59024 ? 296 PRO A CB  1 
ATOM   2418 C CG  . PRO A 1 302 ? 10.15187  4.42084   57.12524 1.000 17.69219 ? 296 PRO A CG  1 
ATOM   2419 C CD  . PRO A 1 302 ? 10.19158  4.92075   58.59120 1.000 18.48493 ? 296 PRO A CD  1 
ATOM   2420 N N   . HIS A 1 303 ? 9.52865   1.36060   58.70186 1.000 19.94415 ? 297 HIS A N   1 
ATOM   2421 C CA  . HIS A 1 303 ? 9.66174   -0.08702  58.82470 1.000 22.40485 ? 297 HIS A CA  1 
ATOM   2422 C C   . HIS A 1 303 ? 8.81453   -0.65758  59.96325 1.000 24.00846 ? 297 HIS A C   1 
ATOM   2423 O O   . HIS A 1 303 ? 8.40946   -1.82262  59.91583 1.000 27.15230 ? 297 HIS A O   1 
ATOM   2424 C CB  . HIS A 1 303 ? 11.15152  -0.40730  59.00080 1.000 24.98592 ? 297 HIS A CB  1 
ATOM   2425 C CG  . HIS A 1 303 ? 11.99810  0.16796   57.90324 0.764 28.29404 ? 297 HIS A CG  1 
ATOM   2426 N ND1 . HIS A 1 303 ? 12.82629  1.25952   58.07647 0.534 30.34964 ? 297 HIS A ND1 1 
ATOM   2427 C CD2 . HIS A 1 303 ? 12.13019  -0.20003  56.60962 0.783 30.30350 ? 297 HIS A CD2 1 
ATOM   2428 C CE1 . HIS A 1 303 ? 13.43837  1.53021   56.93799 0.719 30.90768 ? 297 HIS A CE1 1 
ATOM   2429 N NE2 . HIS A 1 303 ? 13.03184  0.65907   56.03156 0.710 30.89929 ? 297 HIS A NE2 1 
ATOM   2430 N N   . LYS A 1 304 ? 8.51760   0.14309   60.97870 1.000 20.26446 ? 298 LYS A N   1 
ATOM   2431 C CA  . LYS A 1 304 ? 7.72135   -0.29756  62.12130 1.000 20.64228 ? 298 LYS A CA  1 
ATOM   2432 C C   . LYS A 1 304 ? 6.24478   0.01233   61.93334 1.000 19.04503 ? 298 LYS A C   1 
ATOM   2433 O O   . LYS A 1 304 ? 5.40957   -0.46325  62.71532 1.000 20.89663 ? 298 LYS A O   1 
ATOM   2434 C CB  . LYS A 1 304 ? 8.21756   0.36361   63.40582 1.000 21.61016 ? 298 LYS A CB  1 
ATOM   2435 C CG  . LYS A 1 304 ? 9.65141   0.00083   63.78966 1.000 23.48955 ? 298 LYS A CG  1 
ATOM   2436 C CD  . LYS A 1 304 ? 10.09494  0.71061   65.07618 0.886 23.00341 ? 298 LYS A CD  1 
ATOM   2437 C CE  . LYS A 1 304 ? 11.44887  0.13555   65.56244 0.932 24.76526 ? 298 LYS A CE  1 
ATOM   2438 N NZ  . LYS A 1 304 ? 12.07485  0.96390   66.64322 0.728 25.19385 ? 298 LYS A NZ  1 
ATOM   2439 N N   . ARG A 1 305 ? 5.91589   0.77786   60.91235 1.000 17.13694 ? 299 ARG A N   1 
ATOM   2440 C CA  . ARG A 1 305 ? 4.55847   1.22837   60.68777 1.000 15.64262 ? 299 ARG A CA  1 
ATOM   2441 C C   . ARG A 1 305 ? 3.67705   0.04399   60.27435 1.000 15.77018 ? 299 ARG A C   1 
ATOM   2442 O O   . ARG A 1 305 ? 4.10393   -0.84373  59.52880 1.000 18.29486 ? 299 ARG A O   1 
ATOM   2443 C CB  . ARG A 1 305 ? 4.59338   2.31915   59.60242 1.000 15.51998 ? 299 ARG A CB  1 
ATOM   2444 C CG  . ARG A 1 305 ? 3.28654   3.16440   59.46490 1.000 15.76919 ? 299 ARG A CG  1 
ATOM   2445 C CD  . ARG A 1 305 ? 3.49935   4.34466   58.48852 1.000 14.41012 ? 299 ARG A CD  1 
ATOM   2446 N NE  . ARG A 1 305 ? 4.57297   5.22400   58.93868 1.000 13.98691 ? 299 ARG A NE  1 
ATOM   2447 C CZ  . ARG A 1 305 ? 5.40794   5.88186   58.13863 1.000 15.15808 ? 299 ARG A CZ  1 
ATOM   2448 N NH1 . ARG A 1 305 ? 5.29045   5.82786   56.79048 1.000 15.78091 ? 299 ARG A NH1 1 
ATOM   2449 N NH2 . ARG A 1 305 ? 6.38883   6.60742   58.69254 1.000 15.22720 ? 299 ARG A NH2 1 
ATOM   2450 N N   . ILE A 1 306 ? 2.43190   0.03753   60.74176 1.000 15.58001 ? 300 ILE A N   1 
ATOM   2451 C CA  . ILE A 1 306 ? 1.53338   -1.07508  60.42904 1.000 15.57092 ? 300 ILE A CA  1 
ATOM   2452 C C   . ILE A 1 306 ? 1.29748   -1.14007  58.91766 1.000 16.45523 ? 300 ILE A C   1 
ATOM   2453 O O   . ILE A 1 306 ? 1.23312   -0.10591  58.23093 1.000 16.66315 ? 300 ILE A O   1 
ATOM   2454 C CB  . ILE A 1 306 ? 0.20404   -0.87585  61.18651 1.000 16.44975 ? 300 ILE A CB  1 
ATOM   2455 C CG1 . ILE A 1 306 ? -0.61011  -2.17053  61.19896 1.000 16.44161 ? 300 ILE A CG1 1 
ATOM   2456 C CG2 . ILE A 1 306 ? -0.64066  0.29363   60.59983 1.000 17.34284 ? 300 ILE A CG2 1 
ATOM   2457 C CD1 . ILE A 1 306 ? -1.73554  -2.15647  62.21720 1.000 18.02805 ? 300 ILE A CD1 1 
ATOM   2458 N N   . GLU A 1 307 ? 1.12990   -2.36900  58.40187 1.000 16.17855 ? 301 GLU A N   1 
ATOM   2459 C CA  . GLU A 1 307 ? 0.79520   -2.60747  57.00263 1.000 16.07090 ? 301 GLU A CA  1 
ATOM   2460 C C   . GLU A 1 307 ? -0.71537  -2.76255  56.84850 1.000 16.49082 ? 301 GLU A C   1 
ATOM   2461 O O   . GLU A 1 307 ? -1.44165  -2.94404  57.82253 1.000 17.14336 ? 301 GLU A O   1 
ATOM   2462 C CB  . GLU A 1 307 ? 1.50778   -3.85075  56.47239 1.000 17.97154 ? 301 GLU A CB  1 
ATOM   2463 C CG  . GLU A 1 307 ? 2.96393   -3.67808  56.46654 1.000 19.76983 ? 301 GLU A CG  1 
ATOM   2464 C CD  . GLU A 1 307 ? 3.67539   -4.73437  55.63186 0.840 24.01609 ? 301 GLU A CD  1 
ATOM   2465 O OE1 . GLU A 1 307 ? 3.05022   -5.76634  55.27528 0.660 24.86494 ? 301 GLU A OE1 1 
ATOM   2466 O OE2 . GLU A 1 307 ? 4.87727   -4.55828  55.34970 0.774 27.52273 ? 301 GLU A OE2 1 
ATOM   2467 N N   . VAL A 1 308 ? -1.18960  -2.62721  55.60627 1.000 15.68643 ? 302 VAL A N   1 
ATOM   2468 C CA  . VAL A 1 308 ? -2.63191  -2.54196  55.38649 1.000 14.47172 ? 302 VAL A CA  1 
ATOM   2469 C C   . VAL A 1 308 ? -3.36987  -3.77604  55.90125 1.000 16.18424 ? 302 VAL A C   1 
ATOM   2470 O O   . VAL A 1 308 ? -4.46689  -3.65650  56.46003 1.000 16.58805 ? 302 VAL A O   1 
ATOM   2471 C CB  . VAL A 1 308 ? -2.94391  -2.28409  53.89344 1.000 14.38179 ? 302 VAL A CB  1 
ATOM   2472 C CG1 . VAL A 1 308 ? -2.43745  -3.41677  52.93729 1.000 15.22453 ? 302 VAL A CG1 1 
ATOM   2473 C CG2 . VAL A 1 308 ? -4.46650  -1.94853  53.69901 1.000 14.93849 ? 302 VAL A CG2 1 
ATOM   2474 N N   . GLU A 1 309 ? -2.83296  -4.97435  55.67266 1.000 15.70253 ? 303 GLU A N   1 
ATOM   2475 C CA  . GLU A 1 309 ? -3.55311  -6.16736  56.09112 1.000 17.65628 ? 303 GLU A CA  1 
ATOM   2476 C C   . GLU A 1 309 ? -3.59816  -6.29989  57.60511 1.000 18.21714 ? 303 GLU A C   1 
ATOM   2477 O O   . GLU A 1 309 ? -4.59057  -6.82509  58.14964 1.000 18.50097 ? 303 GLU A O   1 
ATOM   2478 C CB  . GLU A 1 309 ? -2.93593  -7.40914  55.48963 1.000 20.20569 ? 303 GLU A CB  1 
ATOM   2479 C CG  . GLU A 1 309 ? -3.25588  -7.62622  53.99518 0.799 20.31402 ? 303 GLU A CG  1 
ATOM   2480 C CD  . GLU A 1 309 ? -2.35687  -8.73657  53.43652 0.926 23.71791 ? 303 GLU A CD  1 
ATOM   2481 O OE1 . GLU A 1 309 ? -1.15722  -8.66561  53.69599 0.396 24.67466 ? 303 GLU A OE1 1 
ATOM   2482 O OE2 . GLU A 1 309 ? -2.85006  -9.62316  52.72328 0.461 25.47270 ? 303 GLU A OE2 1 
ATOM   2483 N N   . GLN A 1 310 ? -2.54634  -5.84117  58.29003 1.000 18.29786 ? 304 GLN A N   1 
ATOM   2484 C CA  . GLN A 1 310 ? -2.54916  -5.76475  59.75865 1.000 18.89658 ? 304 GLN A CA  1 
ATOM   2485 C C   . GLN A 1 310 ? -3.56050  -4.76003  60.25961 1.000 19.00945 ? 304 GLN A C   1 
ATOM   2486 O O   . GLN A 1 310 ? -4.22955  -4.98265  61.28555 1.000 19.68456 ? 304 GLN A O   1 
ATOM   2487 C CB  . GLN A 1 310 ? -1.18277  -5.33922  60.25287 1.000 19.97420 ? 304 GLN A CB  1 
ATOM   2488 C CG  . GLN A 1 310 ? -0.13931  -6.30743  60.11094 0.718 20.77039 ? 304 GLN A CG  1 
ATOM   2489 C CD  . GLN A 1 310 ? 1.17852   -5.68667  60.56272 0.632 20.15738 ? 304 GLN A CD  1 
ATOM   2490 O OE1 . GLN A 1 310 ? 1.68783   -4.75419  59.94413 0.941 22.56300 ? 304 GLN A OE1 1 
ATOM   2491 N NE2 . GLN A 1 310 ? 1.69016   -6.15560  61.67732 0.745 21.16718 ? 304 GLN A NE2 1 
ATOM   2492 N N   . ALA A 1 311 ? -3.67365  -3.64058  59.56036 1.000 16.26277 ? 305 ALA A N   1 
ATOM   2493 C CA  . ALA A 1 311 ? -4.62383  -2.61994  59.98464 1.000 15.98738 ? 305 ALA A CA  1 
ATOM   2494 C C   . ALA A 1 311 ? -6.05015  -3.14863  59.88632 1.000 16.23183 ? 305 ALA A C   1 
ATOM   2495 O O   . ALA A 1 311 ? -6.85716  -2.97205  60.81673 1.000 17.37351 ? 305 ALA A O   1 
ATOM   2496 C CB  . ALA A 1 311 ? -4.43388  -1.35882  59.14551 1.000 15.23294 ? 305 ALA A CB  1 
ATOM   2497 N N   . LEU A 1 312 ? -6.35388  -3.86617  58.80422 1.000 16.33765 ? 306 LEU A N   1 
ATOM   2498 C CA  . LEU A 1 312 ? -7.69623  -4.43203  58.65294 1.000 15.85194 ? 306 LEU A CA  1 
ATOM   2499 C C   . LEU A 1 312 ? -8.03451  -5.39093  59.79538 1.000 17.14048 ? 306 LEU A C   1 
ATOM   2500 O O   . LEU A 1 312 ? -9.19873  -5.48700  60.19594 1.000 17.76117 ? 306 LEU A O   1 
ATOM   2501 C CB  . LEU A 1 312 ? -7.82029  -5.16145  57.30537 1.000 14.76467 ? 306 LEU A CB  1 
ATOM   2502 C CG  . LEU A 1 312 ? -8.04866  -4.20030  56.12437 1.000 13.45975 ? 306 LEU A CG  1 
ATOM   2503 C CD1 . LEU A 1 312 ? -7.72707  -4.85404  54.75260 1.000 14.03117 ? 306 LEU A CD1 1 
ATOM   2504 C CD2 . LEU A 1 312 ? -9.49481  -3.69225  56.13163 1.000 16.11455 ? 306 LEU A CD2 1 
ATOM   2505 N N   . ALA A 1 313 ? -7.04304  -6.12631  60.30253 1.000 17.86416 ? 307 ALA A N   1 
ATOM   2506 C CA  . ALA A 1 313 ? -7.19214  -7.10327  61.38324 1.000 18.65146 ? 307 ALA A CA  1 
ATOM   2507 C C   . ALA A 1 313 ? -7.14569  -6.46173  62.76508 1.000 19.08020 ? 307 ALA A C   1 
ATOM   2508 O O   . ALA A 1 313 ? -7.22388  -7.18172  63.76556 1.000 21.34539 ? 307 ALA A O   1 
ATOM   2509 C CB  . ALA A 1 313 ? -6.09173  -8.17730  61.26282 1.000 19.82429 ? 307 ALA A CB  1 
ATOM   2510 N N   . HIS A 1 314 ? -7.04644  -5.14360  62.85123 1.000 17.86133 ? 308 HIS A N   1 
ATOM   2511 C CA  . HIS A 1 314 ? -6.96347  -4.48312  64.14576 1.000 18.00017 ? 308 HIS A CA  1 
ATOM   2512 C C   . HIS A 1 314 ? -8.32465  -4.52145  64.85647 1.000 18.77693 ? 308 HIS A C   1 
ATOM   2513 O O   . HIS A 1 314 ? -9.36848  -4.39292  64.21194 1.000 20.08386 ? 308 HIS A O   1 
ATOM   2514 C CB  . HIS A 1 314 ? -6.51205  -3.02183  63.92700 1.000 18.39695 ? 308 HIS A CB  1 
ATOM   2515 C CG  . HIS A 1 314 ? -6.22073  -2.29942  65.20172 1.000 19.42873 ? 308 HIS A CG  1 
ATOM   2516 N ND1 . HIS A 1 314 ? -7.21461  -1.78312  66.00547 1.000 18.36891 ? 308 HIS A ND1 1 
ATOM   2517 C CD2 . HIS A 1 314 ? -5.04807  -2.05342  65.83562 1.000 18.23329 ? 308 HIS A CD2 1 
ATOM   2518 C CE1 . HIS A 1 314 ? -6.66644  -1.26621  67.09973 1.000 18.72350 ? 308 HIS A CE1 1 
ATOM   2519 N NE2 . HIS A 1 314 ? -5.34919  -1.40773  67.01448 1.000 19.56707 ? 308 HIS A NE2 1 
ATOM   2520 N N   . PRO A 1 315 ? -8.35131  -4.67814  66.19483 1.000 20.17454 ? 309 PRO A N   1 
ATOM   2521 C CA  . PRO A 1 315 ? -9.63986  -4.75060  66.90221 1.000 21.53499 ? 309 PRO A CA  1 
ATOM   2522 C C   . PRO A 1 315 ? -10.59524 -3.61303  66.61596 1.000 21.09982 ? 309 PRO A C   1 
ATOM   2523 O O   . PRO A 1 315 ? -11.81420 -3.81502  66.72066 1.000 21.31181 ? 309 PRO A O   1 
ATOM   2524 C CB  . PRO A 1 315 ? -9.22245  -4.75298  68.37796 1.000 23.45698 ? 309 PRO A CB  1 
ATOM   2525 C CG  . PRO A 1 315 ? -7.87091  -5.46878  68.36256 1.000 23.07155 ? 309 PRO A CG  1 
ATOM   2526 C CD  . PRO A 1 315 ? -7.20338  -4.97649  67.06851 1.000 22.26858 ? 309 PRO A CD  1 
ATOM   2527 N N   . TYR A 1 316 ? -10.11562 -2.42387  66.26325 1.000 21.33433 ? 310 TYR A N   1 
ATOM   2528 C CA  . TYR A 1 316 ? -11.05489 -1.33458  66.00633 1.000 19.81703 ? 310 TYR A CA  1 
ATOM   2529 C C   . TYR A 1 316 ? -12.00975 -1.68768  64.86226 1.000 18.90774 ? 310 TYR A C   1 
ATOM   2530 O O   . TYR A 1 316 ? -13.16309 -1.24977  64.85486 1.000 19.67009 ? 310 TYR A O   1 
ATOM   2531 C CB  . TYR A 1 316 ? -10.27825 -0.03902  65.67388 1.000 19.13594 ? 310 TYR A CB  1 
ATOM   2532 C CG  . TYR A 1 316 ? -11.18173 1.13946   65.36320 1.000 18.95576 ? 310 TYR A CG  1 
ATOM   2533 C CD1 . TYR A 1 316 ? -12.15108 1.56037   66.27615 1.000 20.70755 ? 310 TYR A CD1 1 
ATOM   2534 C CD2 . TYR A 1 316 ? -11.06947 1.83721   64.17306 1.000 19.15530 ? 310 TYR A CD2 1 
ATOM   2535 C CE1 . TYR A 1 316 ? -12.99207 2.63720   65.99680 1.000 21.58057 ? 310 TYR A CE1 1 
ATOM   2536 C CE2 . TYR A 1 316 ? -11.90852 2.93474   63.89241 1.000 19.37143 ? 310 TYR A CE2 1 
ATOM   2537 C CZ  . TYR A 1 316 ? -12.86325 3.33112   64.81119 1.000 22.33679 ? 310 TYR A CZ  1 
ATOM   2538 O OH  . TYR A 1 316 ? -13.70793 4.40047   64.53357 1.000 24.51171 ? 310 TYR A OH  1 
ATOM   2539 N N   . LEU A 1 317 ? -11.54622 -2.50276  63.89468 1.000 17.56615 ? 311 LEU A N   1 
ATOM   2540 C CA  . LEU A 1 317 ? -12.31056 -2.84230  62.70262 1.000 18.01258 ? 311 LEU A CA  1 
ATOM   2541 C C   . LEU A 1 317 ? -12.97775 -4.21619  62.78285 1.000 18.65887 ? 311 LEU A C   1 
ATOM   2542 O O   . LEU A 1 317 ? -13.42072 -4.73442  61.74540 1.000 21.49257 ? 311 LEU A O   1 
ATOM   2543 C CB  . LEU A 1 317 ? -11.40869 -2.75126  61.45623 1.000 17.00066 ? 311 LEU A CB  1 
ATOM   2544 C CG  . LEU A 1 317 ? -10.84303 -1.32488  61.26065 1.000 16.74095 ? 311 LEU A CG  1 
ATOM   2545 C CD1 . LEU A 1 317 ? -9.86150  -1.29044  60.12800 1.000 18.84075 ? 311 LEU A CD1 1 
ATOM   2546 C CD2 . LEU A 1 317 ? -11.97926 -0.31040  61.02083 1.000 19.66386 ? 311 LEU A CD2 1 
ATOM   2547 N N   . GLU A 1 318 ? -13.08372 -4.80556  63.98168 1.000 19.94473 ? 312 GLU A N   1 
ATOM   2548 C CA  . GLU A 1 318 ? -13.56169 -6.19249  64.12677 1.000 23.76580 ? 312 GLU A CA  1 
ATOM   2549 C C   . GLU A 1 318 ? -14.97302 -6.41451  63.56934 1.000 23.72384 ? 312 GLU A C   1 
ATOM   2550 O O   . GLU A 1 318 ? -15.28895 -7.51355  63.08601 1.000 24.49742 ? 312 GLU A O   1 
ATOM   2551 C CB  . GLU A 1 318 ? -13.49066 -6.59726  65.61474 1.000 25.90319 ? 312 GLU A CB  1 
ATOM   2552 C CG  . GLU A 1 318 ? -13.68255 -8.10753  65.87305 0.681 28.95874 ? 312 GLU A CG  1 
ATOM   2553 C CD  . GLU A 1 318 ? -13.71852 -8.43008  67.34483 0.638 31.84822 ? 312 GLU A CD  1 
ATOM   2554 O OE1 . GLU A 1 318 ? -13.12726 -7.64745  68.12641 0.636 33.49425 ? 312 GLU A OE1 1 
ATOM   2555 O OE2 . GLU A 1 318 ? -14.30965 -9.47205  67.71539 0.417 32.82724 ? 312 GLU A OE2 1 
ATOM   2556 N N   . GLN A 1 319 ? -15.82452 -5.38242  63.61986 1.000 24.21068 ? 313 GLN A N   1 
ATOM   2557 C CA  A GLN A 1 319 ? -17.19657 -5.48251  63.12375 0.524 24.58405 ? 313 GLN A CA  1 
ATOM   2558 C CA  B GLN A 1 319 ? -17.19346 -5.49326  63.11689 0.476 24.61686 ? 313 GLN A CA  1 
ATOM   2559 C C   . GLN A 1 319 ? -17.22184 -5.81166  61.63223 1.000 23.23315 ? 313 GLN A C   1 
ATOM   2560 O O   . GLN A 1 319 ? -18.16688 -6.44448  61.15474 1.000 25.97703 ? 313 GLN A O   1 
ATOM   2561 C CB  A GLN A 1 319 ? -17.90180 -4.14307  63.34229 0.524 26.06768 ? 313 GLN A CB  1 
ATOM   2562 C CB  B GLN A 1 319 ? -17.89620 -4.17269  63.40212 0.476 25.94588 ? 313 GLN A CB  1 
ATOM   2563 C CG  A GLN A 1 319 ? -18.01958 -3.74260  64.80153 0.524 30.96250 ? 313 GLN A CG  1 
ATOM   2564 C CG  B GLN A 1 319 ? -18.11299 -3.92373  64.88165 0.476 29.93033 ? 313 GLN A CG  1 
ATOM   2565 C CD  A GLN A 1 319 ? -16.73836 -3.03310  65.33555 0.524 31.41943 ? 313 GLN A CD  1 
ATOM   2566 C CD  B GLN A 1 319 ? -18.64099 -2.54147  65.12598 0.476 30.43299 ? 313 GLN A CD  1 
ATOM   2567 O OE1 A GLN A 1 319 ? -15.70001 -2.83826  64.60050 0.524 26.66398 ? 313 GLN A OE1 1 
ATOM   2568 O OE1 B GLN A 1 319 ? -18.37575 -1.63183  64.32007 0.476 28.97114 ? 313 GLN A OE1 1 
ATOM   2569 N NE2 A GLN A 1 319 ? -16.81769 -2.62540  66.63289 0.524 34.39228 ? 313 GLN A NE2 1 
ATOM   2570 N NE2 B GLN A 1 319 ? -19.46041 -2.37785  66.17558 0.476 33.06047 ? 313 GLN A NE2 1 
ATOM   2571 N N   . TYR A 1 320 ? -16.19260 -5.37559  60.89190 1.000 20.74598 ? 314 TYR A N   1 
ATOM   2572 C CA  . TYR A 1 320 ? -16.17023 -5.44552  59.44551 1.000 19.76190 ? 314 TYR A CA  1 
ATOM   2573 C C   . TYR A 1 320 ? -15.14660 -6.43486  58.90498 1.000 20.50913 ? 314 TYR A C   1 
ATOM   2574 O O   . TYR A 1 320 ? -15.34831 -6.96763  57.81039 1.000 21.39731 ? 314 TYR A O   1 
ATOM   2575 C CB  . TYR A 1 320 ? -15.83345 -4.06991  58.84329 1.000 20.85813 ? 314 TYR A CB  1 
ATOM   2576 C CG  . TYR A 1 320 ? -16.88472 -3.05492  59.11302 1.000 22.65525 ? 314 TYR A CG  1 
ATOM   2577 C CD1 . TYR A 1 320 ? -18.13114 -3.15951  58.51686 1.000 25.40808 ? 314 TYR A CD1 1 
ATOM   2578 C CD2 . TYR A 1 320 ? -16.66289 -2.01672  60.00688 1.000 24.49108 ? 314 TYR A CD2 1 
ATOM   2579 C CE1 . TYR A 1 320 ? -19.11939 -2.25034  58.80455 1.000 28.41762 ? 314 TYR A CE1 1 
ATOM   2580 C CE2 . TYR A 1 320 ? -17.65197 -1.09221  60.28472 1.000 25.37072 ? 314 TYR A CE2 1 
ATOM   2581 C CZ  . TYR A 1 320 ? -18.87214 -1.21329  59.68631 1.000 28.22819 ? 314 TYR A CZ  1 
ATOM   2582 O OH  . TYR A 1 320 ? -19.84517 -0.28318  59.95799 1.000 30.53029 ? 314 TYR A OH  1 
ATOM   2583 N N   . TYR A 1 321 ? -14.08884 -6.73201  59.66036 1.000 19.76667 ? 315 TYR A N   1 
ATOM   2584 C CA  . TYR A 1 321 ? -12.96560 -7.49742  59.11940 1.000 20.18458 ? 315 TYR A CA  1 
ATOM   2585 C C   . TYR A 1 321 ? -13.39125 -8.86985  58.61279 1.000 20.22805 ? 315 TYR A C   1 
ATOM   2586 O O   . TYR A 1 321 ? -13.98821 -9.67173  59.33936 1.000 23.78786 ? 315 TYR A O   1 
ATOM   2587 C CB  . TYR A 1 321 ? -11.90139 -7.66360  60.19065 1.000 21.75351 ? 315 TYR A CB  1 
ATOM   2588 C CG  . TYR A 1 321 ? -10.68267 -8.46166  59.76701 1.000 20.70100 ? 315 TYR A CG  1 
ATOM   2589 C CD1 . TYR A 1 321 ? -9.98352  -8.12304  58.62077 1.000 20.60541 ? 315 TYR A CD1 1 
ATOM   2590 C CD2 . TYR A 1 321 ? -10.19158 -9.50303  60.54552 1.000 22.12379 ? 315 TYR A CD2 1 
ATOM   2591 C CE1 . TYR A 1 321 ? -8.84450  -8.82505  58.24816 1.000 21.08576 ? 315 TYR A CE1 1 
ATOM   2592 C CE2 . TYR A 1 321 ? -9.07251  -10.20028 60.18300 1.000 23.83242 ? 315 TYR A CE2 1 
ATOM   2593 C CZ  . TYR A 1 321 ? -8.39685  -9.86568  59.04157 1.000 23.32982 ? 315 TYR A CZ  1 
ATOM   2594 O OH  . TYR A 1 321 ? -7.28318  -10.58366 58.68123 1.000 24.46107 ? 315 TYR A OH  1 
ATOM   2595 N N   . ASP A 1 322 ? -13.05083 -9.14950  57.38274 1.000 19.69897 ? 316 ASP A N   1 
ATOM   2596 C CA  . ASP A 1 322 ? -13.36761 -10.43577 56.78789 1.000 20.13490 ? 316 ASP A CA  1 
ATOM   2597 C C   . ASP A 1 322 ? -12.43962 -10.62638 55.59659 1.000 19.08711 ? 316 ASP A C   1 
ATOM   2598 O O   . ASP A 1 322 ? -12.74290 -10.14415 54.49535 1.000 19.25771 ? 316 ASP A O   1 
ATOM   2599 C CB  . ASP A 1 322 ? -14.84083 -10.48709 56.35263 1.000 22.77418 ? 316 ASP A CB  1 
ATOM   2600 C CG  . ASP A 1 322 ? -15.18924 -11.76365 55.64061 0.763 24.95250 ? 316 ASP A CG  1 
ATOM   2601 O OD1 . ASP A 1 322 ? -14.31516 -12.65368 55.51025 0.914 24.83784 ? 316 ASP A OD1 1 
ATOM   2602 O OD2 . ASP A 1 322 ? -16.35170 -11.87630 55.20695 0.839 25.24752 ? 316 ASP A OD2 1 
ATOM   2603 N N   . PRO A 1 323 ? -11.28938 -11.27299 55.79562 1.000 19.92413 ? 317 PRO A N   1 
ATOM   2604 C CA  . PRO A 1 323 ? -10.29020 -11.33055 54.71163 1.000 19.15643 ? 317 PRO A CA  1 
ATOM   2605 C C   . PRO A 1 323 ? -10.81950 -11.94623 53.42042 1.000 19.69531 ? 317 PRO A C   1 
ATOM   2606 O O   . PRO A 1 323 ? -10.32610 -11.61382 52.34075 1.000 20.31864 ? 317 PRO A O   1 
ATOM   2607 C CB  . PRO A 1 323 ? -9.16084  -12.19682 55.30690 1.000 23.34916 ? 317 PRO A CB  1 
ATOM   2608 C CG  . PRO A 1 323 ? -9.38022  -12.25402 56.77721 1.000 24.96588 ? 317 PRO A CG  1 
ATOM   2609 C CD  . PRO A 1 323 ? -10.86155 -11.99608 57.01533 1.000 21.62399 ? 317 PRO A CD  1 
ATOM   2610 N N   . SER A 1 324 ? -11.77236 -12.87801 53.51179 1.000 19.09939 ? 318 SER A N   1 
ATOM   2611 C CA  . SER A 1 324 ? -12.36861 -13.46931 52.31570 1.000 19.51831 ? 318 SER A CA  1 
ATOM   2612 C C   . SER A 1 324 ? -13.22678 -12.48715 51.53485 1.000 20.06828 ? 318 SER A C   1 
ATOM   2613 O O   . SER A 1 324 ? -13.52373 -12.74597 50.36598 1.000 21.05070 ? 318 SER A O   1 
ATOM   2614 C CB  A SER A 1 324 ? -13.22683 -14.68784 52.69284 0.635 20.01312 ? 318 SER A CB  1 
ATOM   2615 C CB  B SER A 1 324 ? -13.16475 -14.71630 52.70436 0.365 17.77255 ? 318 SER A CB  1 
ATOM   2616 O OG  A SER A 1 324 ? -14.52370 -14.29337 53.14027 0.635 21.08084 ? 318 SER A OG  1 
ATOM   2617 O OG  B SER A 1 324 ? -12.40382 -15.50620 53.61281 0.365 16.19313 ? 318 SER A OG  1 
ATOM   2618 N N   . ASP A 1 325 ? -13.61842 -11.36695 52.14289 1.000 18.46418 ? 319 ASP A N   1 
ATOM   2619 C CA  . ASP A 1 325 ? -14.38161 -10.33025 51.46353 1.000 17.46282 ? 319 ASP A CA  1 
ATOM   2620 C C   . ASP A 1 325 ? -13.56115 -9.06927  51.26667 1.000 16.14573 ? 319 ASP A C   1 
ATOM   2621 O O   . ASP A 1 325 ? -14.11978 -7.97137  51.15214 1.000 16.96375 ? 319 ASP A O   1 
ATOM   2622 C CB  . ASP A 1 325 ? -15.66938 -10.02308 52.23868 1.000 20.50614 ? 319 ASP A CB  1 
ATOM   2623 C CG  . ASP A 1 325 ? -16.64280 -9.16168  51.45305 1.000 23.79706 ? 319 ASP A CG  1 
ATOM   2624 O OD1 . ASP A 1 325 ? -16.74671 -9.34393  50.21852 1.000 25.55008 ? 319 ASP A OD1 1 
ATOM   2625 O OD2 . ASP A 1 325 ? -17.28471 -8.26332  52.05712 1.000 24.54328 ? 319 ASP A OD2 1 
ATOM   2626 N N   . GLU A 1 326 ? -12.23487 -9.20003  51.25384 1.000 15.31557 ? 320 GLU A N   1 
ATOM   2627 C CA  . GLU A 1 326 ? -11.32344 -8.07485  51.06757 1.000 16.35715 ? 320 GLU A CA  1 
ATOM   2628 C C   . GLU A 1 326 ? -10.39751 -8.49751  49.93042 1.000 17.20041 ? 320 GLU A C   1 
ATOM   2629 O O   . GLU A 1 326 ? -9.27189  -8.96912  50.15874 1.000 18.26659 ? 320 GLU A O   1 
ATOM   2630 C CB  . GLU A 1 326 ? -10.60416 -7.76417  52.39063 1.000 17.00850 ? 320 GLU A CB  1 
ATOM   2631 C CG  . GLU A 1 326 ? -11.62086 -7.22359  53.41314 1.000 16.88941 ? 320 GLU A CG  1 
ATOM   2632 C CD  . GLU A 1 326 ? -11.19456 -7.41711  54.86290 1.000 18.57418 ? 320 GLU A CD  1 
ATOM   2633 O OE1 . GLU A 1 326 ? -10.05124 -7.88669  55.14548 1.000 18.52725 ? 320 GLU A OE1 1 
ATOM   2634 O OE2 . GLU A 1 326 ? -12.03486 -7.09162  55.73376 1.000 18.52294 ? 320 GLU A OE2 1 
ATOM   2635 N N   . PRO A 1 327 ? -10.85836 -8.37625  48.69389 1.000 17.24568 ? 321 PRO A N   1 
ATOM   2636 C CA  . PRO A 1 327 ? -10.15183 -9.01047  47.57848 1.000 17.00999 ? 321 PRO A CA  1 
ATOM   2637 C C   . PRO A 1 327 ? -8.85828  -8.31146  47.20665 1.000 18.51098 ? 321 PRO A C   1 
ATOM   2638 O O   . PRO A 1 327 ? -8.62432  -7.12763  47.49297 1.000 19.28132 ? 321 PRO A O   1 
ATOM   2639 C CB  . PRO A 1 327 ? -11.15798 -8.94129  46.41641 1.000 19.31336 ? 321 PRO A CB  1 
ATOM   2640 C CG  . PRO A 1 327 ? -12.15183 -7.90652  46.77663 1.000 19.58092 ? 321 PRO A CG  1 
ATOM   2641 C CD  . PRO A 1 327 ? -12.19649 -7.87542  48.29843 1.000 17.48827 ? 321 PRO A CD  1 
ATOM   2642 N N   . ILE A 1 328 ? -8.03327  -9.09221  46.51021 1.000 17.52163 ? 322 ILE A N   1 
ATOM   2643 C CA  . ILE A 1 328 ? -6.74602  -8.64062  45.99705 1.000 17.35034 ? 322 ILE A CA  1 
ATOM   2644 C C   . ILE A 1 328 ? -6.74192  -8.72814  44.48084 1.000 18.40225 ? 322 ILE A C   1 
ATOM   2645 O O   . ILE A 1 328 ? -7.59975  -9.37498  43.85325 1.000 20.21598 ? 322 ILE A O   1 
ATOM   2646 C CB  . ILE A 1 328 ? -5.57345  -9.42192  46.59743 1.000 17.19807 ? 322 ILE A CB  1 
ATOM   2647 C CG1 . ILE A 1 328 ? -5.66052  -10.92337 46.24888 1.000 19.00035 ? 322 ILE A CG1 1 
ATOM   2648 C CG2 . ILE A 1 328 ? -5.52068  -9.18865  48.10281 1.000 19.82714 ? 322 ILE A CG2 1 
ATOM   2649 C CD1 . ILE A 1 328 ? -4.38428  -11.67142 46.57769 1.000 21.84135 ? 322 ILE A CD1 1 
ATOM   2650 N N   . ALA A 1 329 ? -5.73503  -8.07662  43.90156 1.000 18.31706 ? 323 ALA A N   1 
ATOM   2651 C CA  . ALA A 1 329 ? -5.60811  -7.96075  42.46374 1.000 19.86213 ? 323 ALA A CA  1 
ATOM   2652 C C   . ALA A 1 329 ? -5.14102  -9.29710  41.88974 1.000 23.39511 ? 323 ALA A C   1 
ATOM   2653 O O   . ALA A 1 329 ? -4.43639  -10.07498 42.54479 1.000 24.33019 ? 323 ALA A O   1 
ATOM   2654 C CB  . ALA A 1 329 ? -4.60984  -6.84482  42.12533 1.000 20.19680 ? 323 ALA A CB  1 
ATOM   2655 N N   . GLU A 1 330 ? -5.61176  -9.59977  40.69834 1.000 26.40741 ? 324 GLU A N   1 
ATOM   2656 C CA  . GLU A 1 330 ? -5.25440  -10.85287 40.05766 1.000 31.72627 ? 324 GLU A CA  1 
ATOM   2657 C C   . GLU A 1 330 ? -3.79570  -10.91517 39.65381 1.000 35.47622 ? 324 GLU A C   1 
ATOM   2658 O O   . GLU A 1 330 ? -3.28016  -12.00875 39.41392 1.000 38.05633 ? 324 GLU A O   1 
ATOM   2659 C CB  . GLU A 1 330 ? -6.12520  -11.08424 38.82115 1.000 35.18720 ? 324 GLU A CB  1 
ATOM   2660 C CG  . GLU A 1 330 ? -7.50916  -11.61717 39.10405 0.355 36.85014 ? 324 GLU A CG  1 
ATOM   2661 C CD  . GLU A 1 330 ? -8.32127  -11.71771 37.83851 0.141 38.38424 ? 324 GLU A CD  1 
ATOM   2662 O OE1 . GLU A 1 330 ? -9.52293  -11.38798 37.85420 0.264 38.68287 ? 324 GLU A OE1 1 
ATOM   2663 O OE2 . GLU A 1 330 ? -7.73650  -12.14272 36.81979 0.549 39.77009 ? 324 GLU A OE2 1 
ATOM   2664 N N   . ALA A 1 331 ? -3.11028  -9.78431  39.56464 1.000 36.79965 ? 325 ALA A N   1 
ATOM   2665 C CA  . ALA A 1 331 ? -1.70395  -9.82849  39.20136 1.000 38.17700 ? 325 ALA A CA  1 
ATOM   2666 C C   . ALA A 1 331 ? -1.05899  -8.52438  39.58623 1.000 37.35765 ? 325 ALA A C   1 
ATOM   2667 O O   . ALA A 1 331 ? -1.74222  -7.51540  39.68013 1.000 38.35923 ? 325 ALA A O   1 
ATOM   2668 C CB  . ALA A 1 331 ? -1.54204  -10.04836 37.69682 1.000 38.74794 ? 325 ALA A CB  1 
ATOM   2669 N N   . PRO A 1 332 ? 0.24611   -8.49441  39.76548 1.000 38.09071 ? 326 PRO A N   1 
ATOM   2670 C CA  . PRO A 1 332 ? 0.89240   -7.21335  40.05469 1.000 35.34956 ? 326 PRO A CA  1 
ATOM   2671 C C   . PRO A 1 332 ? 0.81507   -6.35424  38.79845 1.000 31.18074 ? 326 PRO A C   1 
ATOM   2672 O O   . PRO A 1 332 ? 0.78175   -6.86454  37.67464 1.000 30.65634 ? 326 PRO A O   1 
ATOM   2673 C CB  . PRO A 1 332 ? 2.35471   -7.58302  40.33411 1.000 37.66516 ? 326 PRO A CB  1 
ATOM   2674 C CG  . PRO A 1 332 ? 2.40799   -9.07308  40.48927 1.000 39.67493 ? 326 PRO A CG  1 
ATOM   2675 C CD  . PRO A 1 332 ? 1.07470   -9.67032  40.09888 1.000 39.74093 ? 326 PRO A CD  1 
ATOM   2676 N N   A PHE A 1 333 ? 0.88481   -5.04652  38.98556 0.495 31.35304 ? 327 PHE A N   1 
ATOM   2677 N N   B PHE A 1 333 ? 0.68436   -5.05943  39.00943 0.505 29.80118 ? 327 PHE A N   1 
ATOM   2678 C CA  A PHE A 1 333 ? 1.34504   -4.19180  37.90513 0.495 34.72346 ? 327 PHE A CA  1 
ATOM   2679 C CA  B PHE A 1 333 ? 0.93916   -4.05928  37.99979 0.505 32.31480 ? 327 PHE A CA  1 
ATOM   2680 C C   A PHE A 1 333 ? 2.84978   -4.34337  37.86625 0.495 38.05659 ? 327 PHE A C   1 
ATOM   2681 C C   B PHE A 1 333 ? 2.41027   -3.98925  37.73203 0.505 34.42166 ? 327 PHE A C   1 
ATOM   2682 O O   A PHE A 1 333 ? 3.49340   -4.40141  38.92194 0.495 39.53428 ? 327 PHE A O   1 
ATOM   2683 O O   B PHE A 1 333 ? 3.12647   -3.39228  38.51742 0.505 35.96511 ? 327 PHE A O   1 
ATOM   2684 C CB  A PHE A 1 333 ? 0.98828   -2.72091  38.11028 0.495 36.82809 ? 327 PHE A CB  1 
ATOM   2685 C CB  B PHE A 1 333 ? 0.46157   -2.67609  38.45709 0.505 33.92709 ? 327 PHE A CB  1 
ATOM   2686 C CG  A PHE A 1 333 ? -0.18251  -2.26806  37.31065 0.495 36.66716 ? 327 PHE A CG  1 
ATOM   2687 C CG  B PHE A 1 333 ? -0.05814  -1.81687  37.35462 0.505 33.38371 ? 327 PHE A CG  1 
ATOM   2688 C CD1 A PHE A 1 333 ? -0.04660  -1.98027  35.95573 0.495 37.72815 ? 327 PHE A CD1 1 
ATOM   2689 C CD1 B PHE A 1 333 ? -1.23217  -2.11665  36.68992 0.505 33.97334 ? 327 PHE A CD1 1 
ATOM   2690 C CD2 A PHE A 1 333 ? -1.41078  -2.09726  37.91102 0.495 36.76777 ? 327 PHE A CD2 1 
ATOM   2691 C CD2 B PHE A 1 333 ? 0.71266   -0.74228  36.91411 0.505 32.96583 ? 327 PHE A CD2 1 
ATOM   2692 C CE1 A PHE A 1 333 ? -1.12964  -1.55936  35.22703 0.495 37.18004 ? 327 PHE A CE1 1 
ATOM   2693 C CE1 B PHE A 1 333 ? -1.65731  -1.32033  35.64441 0.505 33.78400 ? 327 PHE A CE1 1 
ATOM   2694 C CE2 A PHE A 1 333 ? -2.49404  -1.67419  37.19140 0.495 37.28187 ? 327 PHE A CE2 1 
ATOM   2695 C CE2 B PHE A 1 333 ? 0.29803   0.05767   35.87644 0.505 32.74500 ? 327 PHE A CE2 1 
ATOM   2696 C CZ  A PHE A 1 333 ? -2.35783  -1.40387  35.84820 0.495 37.62506 ? 327 PHE A CZ  1 
ATOM   2697 C CZ  B PHE A 1 333 ? -0.88507  -0.22729  35.23798 0.505 33.54218 ? 327 PHE A CZ  1 
ATOM   2698 N N   . ASP A 1 340 ? 9.08110   8.00577   31.48452 1.000 61.38590 ? 334 ASP A N   1 
ATOM   2699 C CA  . ASP A 1 340 ? 9.77202   9.27779   31.27100 1.000 61.02110 ? 334 ASP A CA  1 
ATOM   2700 C C   . ASP A 1 340 ? 10.60639  9.29428   29.99475 1.000 60.20990 ? 334 ASP A C   1 
ATOM   2701 O O   . ASP A 1 340 ? 10.76150  8.27203   29.32089 1.000 60.12187 ? 334 ASP A O   1 
ATOM   2702 C CB  . ASP A 1 340 ? 10.66025  9.63102   32.46364 1.000 62.07658 ? 334 ASP A CB  1 
ATOM   2703 C CG  . ASP A 1 340 ? 10.72416  11.12368  32.69704 0.528 62.26777 ? 334 ASP A CG  1 
ATOM   2704 O OD1 . ASP A 1 340 ? 9.93254   11.83643  32.04254 0.787 61.38430 ? 334 ASP A OD1 1 
ATOM   2705 O OD2 . ASP A 1 340 ? 11.55550  11.58424  33.51400 0.465 62.63949 ? 334 ASP A OD2 1 
ATOM   2706 N N   . ASP A 1 341 ? 11.11761  10.47940  29.65757 0.760 59.35041 ? 335 ASP A N   1 
ATOM   2707 C CA  . ASP A 1 341 ? 11.86554  10.70467  28.42656 0.760 58.40342 ? 335 ASP A CA  1 
ATOM   2708 C C   . ASP A 1 341 ? 10.96468  10.52360  27.22018 0.760 57.22876 ? 335 ASP A C   1 
ATOM   2709 O O   . ASP A 1 341 ? 11.40033  10.74894  26.08824 0.760 56.64066 ? 335 ASP A O   1 
ATOM   2710 C CB  . ASP A 1 341 ? 13.07474  9.76975   28.30499 0.760 57.56694 ? 335 ASP A CB  1 
ATOM   2711 C CG  . ASP A 1 341 ? 13.85268  9.64807   29.59548 0.760 57.70739 ? 335 ASP A CG  1 
ATOM   2712 O OD1 . ASP A 1 341 ? 13.71816  10.53637  30.46292 0.760 58.79680 ? 335 ASP A OD1 1 
ATOM   2713 O OD2 . ASP A 1 341 ? 14.60102  8.65996   29.73728 0.760 55.98969 ? 335 ASP A OD2 1 
ATOM   2714 N N   . LEU A 1 342 ? 9.72760   10.08901  27.45390 1.000 56.71986 ? 336 LEU A N   1 
ATOM   2715 C CA  . LEU A 1 342 ? 8.75949   9.93150   26.39475 1.000 57.00468 ? 336 LEU A CA  1 
ATOM   2716 C C   . LEU A 1 342 ? 8.22714   11.31089  26.05246 1.000 54.75559 ? 336 LEU A C   1 
ATOM   2717 O O   . LEU A 1 342 ? 7.66594   11.97762  26.93229 1.000 53.51859 ? 336 LEU A O   1 
ATOM   2718 C CB  . LEU A 1 342 ? 7.62780   9.01615   26.84626 1.000 58.75392 ? 336 LEU A CB  1 
ATOM   2719 C CG  . LEU A 1 342 ? 7.77903   7.53147   26.52191 1.000 59.85155 ? 336 LEU A CG  1 
ATOM   2720 C CD1 . LEU A 1 342 ? 8.06920   7.36527   25.05328 1.000 60.23482 ? 336 LEU A CD1 1 
ATOM   2721 C CD2 . LEU A 1 342 ? 8.90310   6.91410   27.33240 1.000 60.11035 ? 336 LEU A CD2 1 
ATOM   2722 N N   . PRO A 1 343 ? 8.44874   11.81548  24.84350 1.000 54.21853 ? 337 PRO A N   1 
ATOM   2723 C CA  . PRO A 1 343 ? 7.89436   13.12255  24.51772 1.000 52.97736 ? 337 PRO A CA  1 
ATOM   2724 C C   . PRO A 1 343 ? 6.37522   13.04408  24.53393 1.000 50.62807 ? 337 PRO A C   1 
ATOM   2725 O O   . PRO A 1 343 ? 5.77695   11.98932  24.28944 1.000 51.22926 ? 337 PRO A O   1 
ATOM   2726 C CB  . PRO A 1 343 ? 8.46773   13.41124  23.12388 1.000 54.63065 ? 337 PRO A CB  1 
ATOM   2727 C CG  . PRO A 1 343 ? 8.69599   12.04445  22.52841 1.000 54.84284 ? 337 PRO A CG  1 
ATOM   2728 C CD  . PRO A 1 343 ? 9.18301   11.23109  23.70098 1.000 54.77767 ? 337 PRO A CD  1 
ATOM   2729 N N   . LYS A 1 344 ? 5.75417   14.15595  24.91387 1.000 48.73210 ? 338 LYS A N   1 
ATOM   2730 C CA  . LYS A 1 344 ? 4.29985   14.21057  24.90802 1.000 49.10209 ? 338 LYS A CA  1 
ATOM   2731 C C   . LYS A 1 344 ? 3.67260   13.65477  23.63271 1.000 50.36732 ? 338 LYS A C   1 
ATOM   2732 O O   . LYS A 1 344 ? 2.51008   13.23458  23.67821 1.000 49.85949 ? 338 LYS A O   1 
ATOM   2733 C CB  . LYS A 1 344 ? 3.81551   15.64375  25.10372 1.000 48.54169 ? 338 LYS A CB  1 
ATOM   2734 C CG  . LYS A 1 344 ? 4.48747   16.63073  24.17618 0.696 47.90016 ? 338 LYS A CG  1 
ATOM   2735 C CD  . LYS A 1 344 ? 3.96043   18.03813  24.40247 0.733 47.50237 ? 338 LYS A CD  1 
ATOM   2736 C CE  . LYS A 1 344 ? 4.21387   18.91951  23.18132 0.471 48.22947 ? 338 LYS A CE  1 
ATOM   2737 N NZ  . LYS A 1 344 ? 4.23572   20.35805  23.54758 0.165 48.13428 ? 338 LYS A NZ  1 
ATOM   2738 N N   . GLU A 1 345 ? 4.39442   13.63795  22.49849 1.000 50.06350 ? 339 GLU A N   1 
ATOM   2739 C CA  . GLU A 1 345 ? 3.77348   13.17762  21.25632 1.000 50.71716 ? 339 GLU A CA  1 
ATOM   2740 C C   . GLU A 1 345 ? 3.56055   11.67074  21.26122 1.000 48.66813 ? 339 GLU A C   1 
ATOM   2741 O O   . GLU A 1 345 ? 2.48835   11.18146  20.85643 1.000 48.23917 ? 339 GLU A O   1 
ATOM   2742 C CB  . GLU A 1 345 ? 4.60511   13.59022  20.04289 0.347 51.20910 ? 339 GLU A CB  1 
ATOM   2743 C CG  . GLU A 1 345 ? 4.47036   15.04466  19.70623 0.813 51.92537 ? 339 GLU A CG  1 
ATOM   2744 C CD  . GLU A 1 345 ? 5.37527   15.85101  20.57970 0.329 53.23129 ? 339 GLU A CD  1 
ATOM   2745 O OE1 . GLU A 1 345 ? 6.46672   15.32039  20.87145 0.935 52.18661 ? 339 GLU A OE1 1 
ATOM   2746 O OE2 . GLU A 1 345 ? 4.99729   16.98097  20.97808 0.921 55.22775 ? 339 GLU A OE2 1 
ATOM   2747 N N   . LYS A 1 346 ? 4.57794   10.91403  21.68123 1.000 45.97767 ? 340 LYS A N   1 
ATOM   2748 C CA  . LYS A 1 346 ? 4.34532   9.50294   21.91196 1.000 44.68964 ? 340 LYS A CA  1 
ATOM   2749 C C   . LYS A 1 346 ? 3.29507   9.31254   22.99894 1.000 43.92152 ? 340 LYS A C   1 
ATOM   2750 O O   . LYS A 1 346 ? 2.49353   8.37811   22.91844 1.000 44.42034 ? 340 LYS A O   1 
ATOM   2751 C CB  . LYS A 1 346 ? 5.64623   8.78400   22.28792 1.000 42.53007 ? 340 LYS A CB  1 
ATOM   2752 C CG  . LYS A 1 346 ? 6.63383   8.72158   21.13653 0.405 43.58057 ? 340 LYS A CG  1 
ATOM   2753 C CD  . LYS A 1 346 ? 6.15168   7.79947   20.02359 0.738 44.21924 ? 340 LYS A CD  1 
ATOM   2754 C CE  . LYS A 1 346 ? 7.15732   7.74609   18.88080 0.415 45.57661 ? 340 LYS A CE  1 
ATOM   2755 N NZ  . LYS A 1 346 ? 6.70169   6.89188   17.74116 0.852 46.87342 ? 340 LYS A NZ  1 
ATOM   2756 N N   . LEU A 1 347 ? 3.25288   10.20861  23.99473 1.000 41.87341 ? 341 LEU A N   1 
ATOM   2757 C CA  . LEU A 1 347 ? 2.31557   10.00935  25.10101 1.000 39.80099 ? 341 LEU A CA  1 
ATOM   2758 C C   . LEU A 1 347 ? 0.89086   10.30376  24.66133 1.000 38.49614 ? 341 LEU A C   1 
ATOM   2759 O O   . LEU A 1 347 ? -0.05405  9.63547   25.10896 1.000 38.81940 ? 341 LEU A O   1 
ATOM   2760 C CB  . LEU A 1 347 ? 2.66426   10.89067  26.29097 1.000 40.47470 ? 341 LEU A CB  1 
ATOM   2761 C CG  . LEU A 1 347 ? 3.94683   10.58300  27.08518 1.000 43.27810 ? 341 LEU A CG  1 
ATOM   2762 C CD1 . LEU A 1 347 ? 4.12730   11.57874  28.24677 1.000 44.00914 ? 341 LEU A CD1 1 
ATOM   2763 C CD2 . LEU A 1 347 ? 3.88801   9.15008   27.61776 1.000 44.70298 ? 341 LEU A CD2 1 
ATOM   2764 N N   . LYS A 1 348 ? 0.70360   11.32758  23.81953 1.000 38.24474 ? 342 LYS A N   1 
ATOM   2765 C CA  . LYS A 1 348 ? -0.62821  11.53209  23.26511 1.000 37.93809 ? 342 LYS A CA  1 
ATOM   2766 C C   . LYS A 1 348 ? -1.06268  10.32275  22.45740 1.000 38.09423 ? 342 LYS A C   1 
ATOM   2767 O O   . LYS A 1 348 ? -2.21612  9.86910   22.55811 1.000 36.27458 ? 342 LYS A O   1 
ATOM   2768 C CB  . LYS A 1 348 ? -0.66617  12.76571  22.37637 1.000 36.66742 ? 342 LYS A CB  1 
ATOM   2769 C CG  . LYS A 1 348 ? -2.05257  12.99063  21.79740 1.000 35.55471 ? 342 LYS A CG  1 
ATOM   2770 C CD  . LYS A 1 348 ? -2.07955  14.26185  20.93739 1.000 36.66051 ? 342 LYS A CD  1 
ATOM   2771 C CE  . LYS A 1 348 ? -3.49947  14.59535  20.50909 1.000 36.51447 ? 342 LYS A CE  1 
ATOM   2772 N NZ  . LYS A 1 348 ? -3.59130  15.85695  19.69640 1.000 38.12915 ? 342 LYS A NZ  1 
ATOM   2773 N N   . GLU A 1 349 ? -0.14745  9.80557   21.63622 1.000 39.58308 ? 343 GLU A N   1 
ATOM   2774 C CA  . GLU A 1 349 ? -0.37620  8.56729   20.90643 1.000 40.27835 ? 343 GLU A CA  1 
ATOM   2775 C C   . GLU A 1 349 ? -0.71986  7.42775   21.85492 1.000 39.25511 ? 343 GLU A C   1 
ATOM   2776 O O   . GLU A 1 349 ? -1.66705  6.66683   21.60553 1.000 40.18828 ? 343 GLU A O   1 
ATOM   2777 C CB  . GLU A 1 349 ? 0.86815   8.24480   20.06153 1.000 42.76774 ? 343 GLU A CB  1 
ATOM   2778 C CG  . GLU A 1 349 ? 0.57997   7.50945   18.75920 1.000 44.76601 ? 343 GLU A CG  1 
ATOM   2779 C CD  . GLU A 1 349 ? 1.78105   6.74072   18.22273 0.093 46.99039 ? 343 GLU A CD  1 
ATOM   2780 O OE1 . GLU A 1 349 ? 1.59462   5.78832   17.43592 0.584 48.38722 ? 343 GLU A OE1 1 
ATOM   2781 O OE2 . GLU A 1 349 ? 2.92041   7.10751   18.56765 0.618 47.81344 ? 343 GLU A OE2 1 
ATOM   2782 N N   . LEU A 1 350 ? -0.00627  7.32061   22.97978 1.000 37.20991 ? 344 LEU A N   1 
ATOM   2783 C CA  . LEU A 1 350 ? -0.31757  6.23437   23.90215 1.000 37.17677 ? 344 LEU A CA  1 
ATOM   2784 C C   . LEU A 1 350 ? -1.68465  6.42889   24.56131 1.000 34.52964 ? 344 LEU A C   1 
ATOM   2785 O O   . LEU A 1 350 ? -2.40863  5.45474   24.79647 1.000 33.62372 ? 344 LEU A O   1 
ATOM   2786 C CB  . LEU A 1 350 ? 0.75985   6.09318   24.95824 1.000 39.04880 ? 344 LEU A CB  1 
ATOM   2787 C CG  . LEU A 1 350 ? 2.05723   5.54790   24.34567 1.000 40.65032 ? 344 LEU A CG  1 
ATOM   2788 C CD1 . LEU A 1 350 ? 3.20613   5.75258   25.31976 1.000 41.40895 ? 344 LEU A CD1 1 
ATOM   2789 C CD2 . LEU A 1 350 ? 1.87569   4.11015   23.90559 1.000 42.00571 ? 344 LEU A CD2 1 
ATOM   2790 N N   . ILE A 1 351 ? -2.04042  7.67070   24.88990 1.000 32.71146 ? 345 ILE A N   1 
ATOM   2791 C CA  . ILE A 1 351 ? -3.36451  7.95102   25.46442 1.000 29.05708 ? 345 ILE A CA  1 
ATOM   2792 C C   . ILE A 1 351 ? -4.46223  7.64363   24.45314 1.000 28.20357 ? 345 ILE A C   1 
ATOM   2793 O O   . ILE A 1 351 ? -5.48998  7.04504   24.78031 1.000 28.45498 ? 345 ILE A O   1 
ATOM   2794 C CB  . ILE A 1 351 ? -3.42710  9.40455   25.95061 1.000 27.39363 ? 345 ILE A CB  1 
ATOM   2795 C CG1 . ILE A 1 351 ? -2.55787  9.53556   27.22091 1.000 28.86584 ? 345 ILE A CG1 1 
ATOM   2796 C CG2 . ILE A 1 351 ? -4.88362  9.81970   26.26392 1.000 25.69440 ? 345 ILE A CG2 1 
ATOM   2797 C CD1 . ILE A 1 351 ? -2.15413  10.97377  27.62290 1.000 29.95946 ? 345 ILE A CD1 1 
ATOM   2798 N N   . PHE A 1 352 ? -4.26670  8.04756   23.20620 1.000 28.91802 ? 346 PHE A N   1 
ATOM   2799 C CA  . PHE A 1 352 ? -5.21666  7.68786   22.16091 1.000 28.88959 ? 346 PHE A CA  1 
ATOM   2800 C C   . PHE A 1 352 ? -5.40912  6.17549   22.09213 1.000 28.75830 ? 346 PHE A C   1 
ATOM   2801 O O   . PHE A 1 352 ? -6.54039  5.66925   22.01405 1.000 29.13186 ? 346 PHE A O   1 
ATOM   2802 C CB  . PHE A 1 352 ? -4.71432  8.24537   20.81869 1.000 28.51554 ? 346 PHE A CB  1 
ATOM   2803 C CG  . PHE A 1 352 ? -5.64058  7.98777   19.65663 1.000 28.11654 ? 346 PHE A CG  1 
ATOM   2804 C CD1 . PHE A 1 352 ? -6.68721  8.86945   19.40705 1.000 27.58710 ? 346 PHE A CD1 1 
ATOM   2805 C CD2 . PHE A 1 352 ? -5.44125  6.91675   18.78353 1.000 28.65965 ? 346 PHE A CD2 1 
ATOM   2806 C CE1 . PHE A 1 352 ? -7.55526  8.70298   18.31105 1.000 27.10548 ? 346 PHE A CE1 1 
ATOM   2807 C CE2 . PHE A 1 352 ? -6.30622  6.73414   17.69507 1.000 27.82266 ? 346 PHE A CE2 1 
ATOM   2808 C CZ  . PHE A 1 352 ? -7.37022  7.64772   17.45551 1.000 28.24166 ? 346 PHE A CZ  1 
ATOM   2809 N N   . GLU A 1 353 ? -4.31528  5.43360   22.13706 1.000 28.79955 ? 347 GLU A N   1 
ATOM   2810 C CA  . GLU A 1 353 ? -4.41667  4.00271   21.96887 1.000 30.61276 ? 347 GLU A CA  1 
ATOM   2811 C C   . GLU A 1 353 ? -5.03938  3.35998   23.21100 1.000 31.07158 ? 347 GLU A C   1 
ATOM   2812 O O   . GLU A 1 353 ? -5.87452  2.44948   23.10628 1.000 32.54197 ? 347 GLU A O   1 
ATOM   2813 C CB  . GLU A 1 353 ? -3.02114  3.42441   21.66409 1.000 33.98197 ? 347 GLU A CB  1 
ATOM   2814 C CG  . GLU A 1 353 ? -3.07489  1.94563   21.50899 0.514 35.85867 ? 347 GLU A CG  1 
ATOM   2815 C CD  . GLU A 1 353 ? -4.08805  1.58127   20.43035 0.156 37.16536 ? 347 GLU A CD  1 
ATOM   2816 O OE1 . GLU A 1 353 ? -4.00814  2.17366   19.32847 0.349 38.34093 ? 347 GLU A OE1 1 
ATOM   2817 O OE2 . GLU A 1 353 ? -4.99764  0.76513   20.69196 0.481 37.57602 ? 347 GLU A OE2 1 
ATOM   2818 N N   . GLU A 1 354 ? -4.70473  3.87248   24.39698 1.000 29.75827 ? 348 GLU A N   1 
ATOM   2819 C CA  . GLU A 1 354 ? -5.24276  3.30664   25.62750 1.000 30.24634 ? 348 GLU A CA  1 
ATOM   2820 C C   . GLU A 1 354 ? -6.74215  3.52317   25.73506 1.000 27.72057 ? 348 GLU A C   1 
ATOM   2821 O O   . GLU A 1 354 ? -7.41957  2.75957   26.44258 1.000 29.90825 ? 348 GLU A O   1 
ATOM   2822 C CB  . GLU A 1 354 ? -4.51579  3.91895   26.82327 1.000 32.09189 ? 348 GLU A CB  1 
ATOM   2823 C CG  . GLU A 1 354 ? -4.63548  3.15289   28.11976 0.529 34.18171 ? 348 GLU A CG  1 
ATOM   2824 C CD  . GLU A 1 354 ? -3.85333  1.84901   28.11919 0.862 36.53591 ? 348 GLU A CD  1 
ATOM   2825 O OE1 . GLU A 1 354 ? -2.89367  1.69993   27.32668 0.944 39.74497 ? 348 GLU A OE1 1 
ATOM   2826 O OE2 . GLU A 1 354 ? -4.20958  0.97514   28.91965 0.586 37.03874 ? 348 GLU A OE2 1 
ATOM   2827 N N   . THR A 1 355 ? -7.27760  4.54337   25.05953 1.000 24.26557 ? 349 THR A N   1 
ATOM   2828 C CA  . THR A 1 355 ? -8.68199  4.88968   25.16560 1.000 23.96923 ? 349 THR A CA  1 
ATOM   2829 C C   . THR A 1 355 ? -9.50594  4.34150   24.01433 1.000 24.73881 ? 349 THR A C   1 
ATOM   2830 O O   . THR A 1 355 ? -10.73968 4.53117   23.99504 1.000 23.67478 ? 349 THR A O   1 
ATOM   2831 C CB  . THR A 1 355 ? -8.85111  6.42184   25.26466 1.000 23.41448 ? 349 THR A CB  1 
ATOM   2832 O OG1 . THR A 1 355 ? -8.29022  7.04830   24.10388 1.000 24.07004 ? 349 THR A OG1 1 
ATOM   2833 C CG2 . THR A 1 355 ? -8.15178  6.95519   26.50886 1.000 23.54771 ? 349 THR A CG2 1 
ATOM   2834 N N   . ALA A 1 356 ? -8.87733  3.58053   23.11385 1.000 26.70063 ? 350 ALA A N   1 
ATOM   2835 C CA  . ALA A 1 356 ? -9.56925  3.11986   21.91748 1.000 29.24201 ? 350 ALA A CA  1 
ATOM   2836 C C   . ALA A 1 356 ? -10.72395 2.17940   22.22381 1.000 30.67315 ? 350 ALA A C   1 
ATOM   2837 O O   . ALA A 1 356 ? -11.66462 2.10175   21.42958 1.000 30.01136 ? 350 ALA A O   1 
ATOM   2838 C CB  . ALA A 1 356 ? -8.60076  2.41482   20.98906 1.000 30.10454 ? 350 ALA A CB  1 
ATOM   2839 N N   . ARG A 1 357 ? -10.67549 1.45690   23.35230 1.000 31.58445 ? 351 ARG A N   1 
ATOM   2840 C CA  . ARG A 1 357 ? -11.67625 0.42931   23.60366 1.000 32.30737 ? 351 ARG A CA  1 
ATOM   2841 C C   . ARG A 1 357 ? -13.07098 1.02089   23.79275 1.000 31.98397 ? 351 ARG A C   1 
ATOM   2842 O O   . ARG A 1 357 ? -14.07211 0.28936   23.68244 1.000 33.43969 ? 351 ARG A O   1 
ATOM   2843 C CB  . ARG A 1 357 ? -11.27037 -0.43002  24.82796 1.000 32.09818 ? 351 ARG A CB  1 
ATOM   2844 C CG  . ARG A 1 357 ? -11.63094 0.21007   26.15706 0.657 32.76625 ? 351 ARG A CG  1 
ATOM   2845 C CD  . ARG A 1 357 ? -11.22690 -0.64339  27.35479 0.881 34.45833 ? 351 ARG A CD  1 
ATOM   2846 N NE  . ARG A 1 357 ? -9.78861  -0.81049  27.47741 0.599 35.36417 ? 351 ARG A NE  1 
ATOM   2847 C CZ  . ARG A 1 357 ? -9.22882  -1.46234  28.48840 0.217 35.51889 ? 351 ARG A CZ  1 
ATOM   2848 N NH1 . ARG A 1 357 ? -9.96265  -1.99707  29.44867 0.227 35.68526 ? 351 ARG A NH1 1 
ATOM   2849 N NH2 . ARG A 1 357 ? -7.90600  -1.58091  28.53839 0.686 35.77480 ? 351 ARG A NH2 1 
ATOM   2850 N N   . PHE A 1 358 ? -13.16907 2.32200   24.05457 1.000 27.95180 ? 352 PHE A N   1 
ATOM   2851 C CA  . PHE A 1 358 ? -14.46198 2.92972   24.29953 1.000 26.97838 ? 352 PHE A CA  1 
ATOM   2852 C C   . PHE A 1 358 ? -15.05773 3.56108   23.04731 1.000 28.35922 ? 352 PHE A C   1 
ATOM   2853 O O   . PHE A 1 358 ? -16.13507 4.16187   23.12030 1.000 27.92353 ? 352 PHE A O   1 
ATOM   2854 C CB  . PHE A 1 358 ? -14.32479 3.96192   25.42038 1.000 24.70024 ? 352 PHE A CB  1 
ATOM   2855 C CG  . PHE A 1 358 ? -13.92498 3.35783   26.74342 1.000 26.05990 ? 352 PHE A CG  1 
ATOM   2856 C CD1 . PHE A 1 358 ? -14.86674 2.76818   27.55776 1.000 26.63500 ? 352 PHE A CD1 1 
ATOM   2857 C CD2 . PHE A 1 358 ? -12.59542 3.37016   27.15918 1.000 28.54138 ? 352 PHE A CD2 1 
ATOM   2858 C CE1 . PHE A 1 358 ? -14.51631 2.20762   28.76625 1.000 27.33197 ? 352 PHE A CE1 1 
ATOM   2859 C CE2 . PHE A 1 358 ? -12.23733 2.81942   28.37852 1.000 30.87356 ? 352 PHE A CE2 1 
ATOM   2860 C CZ  . PHE A 1 358 ? -13.20646 2.23577   29.18833 1.000 30.00596 ? 352 PHE A CZ  1 
ATOM   2861 N N   . GLN A 1 359 ? -14.39455 3.45083   21.91936 1.000 28.25838 ? 353 GLN A N   1 
ATOM   2862 C CA  . GLN A 1 359 ? -14.95679 3.91039   20.65598 1.000 33.01064 ? 353 GLN A CA  1 
ATOM   2863 C C   . GLN A 1 359 ? -15.84978 2.82382   20.06125 1.000 39.15079 ? 353 GLN A C   1 
ATOM   2864 O O   . GLN A 1 359 ? -15.66268 1.63366   20.34721 1.000 41.56404 ? 353 GLN A O   1 
ATOM   2865 C CB  . GLN A 1 359 ? -13.84045 4.23615   19.66818 1.000 29.92794 ? 353 GLN A CB  1 
ATOM   2866 C CG  . GLN A 1 359 ? -12.97435 5.37857   20.14017 1.000 25.80540 ? 353 GLN A CG  1 
ATOM   2867 C CD  . GLN A 1 359 ? -13.70518 6.71843   20.08930 1.000 26.24868 ? 353 GLN A CD  1 
ATOM   2868 O OE1 . GLN A 1 359 ? -14.33341 7.08539   19.07153 1.000 28.45149 ? 353 GLN A OE1 1 
ATOM   2869 N NE2 . GLN A 1 359 ? -13.69368 7.43027   21.22860 1.000 23.74966 ? 353 GLN A NE2 1 
ATOM   2870 N N   . PRO A 1 360 ? -16.82784 3.19720   19.23685 0.845 43.41006 ? 354 PRO A N   1 
ATOM   2871 C CA  . PRO A 1 360 ? -17.59006 2.26754   18.38703 0.845 44.95481 ? 354 PRO A CA  1 
ATOM   2872 C C   . PRO A 1 360 ? -16.69034 1.34089   17.58265 0.845 46.40688 ? 354 PRO A C   1 
ATOM   2873 O O   . PRO A 1 360 ? -16.70191 0.14483   17.83644 0.845 48.69849 ? 354 PRO A O   1 
ATOM   2874 C CB  . PRO A 1 360 ? -18.34011 3.19160   17.42911 0.845 45.36114 ? 354 PRO A CB  1 
ATOM   2875 C CG  . PRO A 1 360 ? -17.94270 4.59472   17.81764 0.845 44.76921 ? 354 PRO A CG  1 
ATOM   2876 C CD  . PRO A 1 360 ? -17.44273 4.52865   19.23243 0.845 44.47529 ? 354 PRO A CD  1 
HETATM 2877 S S   A SO4 B 2 .   ? 4.19222   21.93823  49.46455 0.481 30.81198 ? 401 SO4 A S   1 
HETATM 2878 S S   B SO4 B 2 .   ? 6.31181   21.93432  49.22309 0.519 22.90965 ? 401 SO4 A S   1 
HETATM 2879 O O1  A SO4 B 2 .   ? 5.05510   23.00760  48.96417 0.481 31.55820 ? 401 SO4 A O1  1 
HETATM 2880 O O1  B SO4 B 2 .   ? 7.48519   22.80555  49.08733 0.519 21.96707 ? 401 SO4 A O1  1 
HETATM 2881 O O2  A SO4 B 2 .   ? 4.37563   20.71344  48.67507 0.481 31.10306 ? 401 SO4 A O2  1 
HETATM 2882 O O2  B SO4 B 2 .   ? 6.42663   20.75788  48.35394 0.519 21.33034 ? 401 SO4 A O2  1 
HETATM 2883 O O3  A SO4 B 2 .   ? 2.79784   22.39114  49.34410 0.481 30.47225 ? 401 SO4 A O3  1 
HETATM 2884 O O3  B SO4 B 2 .   ? 5.10557   22.69900  48.90035 0.519 25.03137 ? 401 SO4 A O3  1 
HETATM 2885 O O4  A SO4 B 2 .   ? 4.55147   21.63491  50.84229 0.481 29.62401 ? 401 SO4 A O4  1 
HETATM 2886 O O4  B SO4 B 2 .   ? 6.24233   21.48755  50.61089 0.519 22.48540 ? 401 SO4 A O4  1 
HETATM 2887 S S   . SO4 C 2 .   ? 5.08659   -4.50447  61.53589 0.582 56.56343 ? 402 SO4 A S   1 
HETATM 2888 O O1  . SO4 C 2 .   ? 4.66713   -3.98823  60.22237 0.582 55.44157 ? 402 SO4 A O1  1 
HETATM 2889 O O2  . SO4 C 2 .   ? 4.90566   -5.95300  61.60372 0.582 56.25873 ? 402 SO4 A O2  1 
HETATM 2890 O O3  . SO4 C 2 .   ? 4.28734   -3.89709  62.59937 0.582 57.01757 ? 402 SO4 A O3  1 
HETATM 2891 O O4  . SO4 C 2 .   ? 6.50830   -4.24646  61.76045 0.582 54.94708 ? 402 SO4 A O4  1 
HETATM 2892 C C3  . WNT D 3 .   ? -18.33756 12.98664  42.04106 1.000 22.47494 ? 403 WNT A C3  1 
HETATM 2893 C C5  . WNT D 3 .   ? -16.62683 14.66338  42.21654 1.000 24.54126 ? 403 WNT A C5  1 
HETATM 2894 C C6  . WNT D 3 .   ? -17.54380 15.48354  42.87541 1.000 24.81417 ? 403 WNT A C6  1 
HETATM 2895 C C9  . WNT D 3 .   ? -13.17413 16.28013  42.88165 1.000 24.09770 ? 403 WNT A C9  1 
HETATM 2896 C C10 . WNT D 3 .   ? -12.30416 15.36494  43.74468 1.000 25.46993 ? 403 WNT A C10 1 
HETATM 2897 C C11 . WNT D 3 .   ? -10.84310 15.24811  43.30785 1.000 25.37350 ? 403 WNT A C11 1 
HETATM 2898 C C8  . WNT D 3 .   ? -14.58763 15.73887  43.01093 1.000 24.34098 ? 403 WNT A C8  1 
HETATM 2899 C C2  . WNT D 3 .   ? -19.24746 13.79919  42.71659 1.000 23.28558 ? 403 WNT A C2  1 
HETATM 2900 C C7  . WNT D 3 .   ? -15.25154 15.20669  41.99985 1.000 23.55766 ? 403 WNT A C7  1 
HETATM 2901 C C16 . WNT D 3 .   ? -13.92845 12.06203  40.12345 1.000 20.50218 ? 403 WNT A C16 1 
HETATM 2902 C C15 . WNT D 3 .   ? -12.51452 12.58265  40.42304 1.000 19.69203 ? 403 WNT A C15 1 
HETATM 2903 C C13 . WNT D 3 .   ? -10.66033 12.88632  42.16869 1.000 21.94788 ? 403 WNT A C13 1 
HETATM 2904 C C12 . WNT D 3 .   ? -10.66784 14.40661  42.06476 1.000 25.27795 ? 403 WNT A C12 1 
HETATM 2905 C C18 . WNT D 3 .   ? -16.13123 12.43423  41.09917 1.000 21.47299 ? 403 WNT A C18 1 
HETATM 2906 C C17 . WNT D 3 .   ? -14.36040 12.37691  38.67558 1.000 22.47616 ? 403 WNT A C17 1 
HETATM 2907 C C   . WNT D 3 .   ? -21.01056 15.57008  43.97940 1.000 29.14834 ? 403 WNT A C   1 
HETATM 2908 O O   . WNT D 3 .   ? -19.66528 15.93228  43.74179 1.000 29.73693 ? 403 WNT A O   1 
HETATM 2909 C C1  . WNT D 3 .   ? -18.83487 15.06692  43.09652 1.000 25.46773 ? 403 WNT A C1  1 
HETATM 2910 C C14 . WNT D 3 .   ? -12.02100 12.21273  41.82499 1.000 18.95652 ? 403 WNT A C14 1 
HETATM 2911 C C4  . WNT D 3 .   ? -17.03977 13.39429  41.81024 1.000 22.96905 ? 403 WNT A C4  1 
HETATM 2912 O O1  . WNT D 3 .   ? -18.70974 11.74071  41.62106 1.000 21.71870 ? 403 WNT A O1  1 
HETATM 2913 O O2  . WNT D 3 .   ? -12.29017 15.91323  45.07394 1.000 27.57509 ? 403 WNT A O2  1 
HETATM 2914 O O3  . WNT D 3 .   ? -10.37090 16.58000  43.07061 1.000 28.61402 ? 403 WNT A O3  1 
HETATM 2915 O O4  . WNT D 3 .   ? -10.51015 14.96426  40.95827 1.000 27.74140 ? 403 WNT A O4  1 
HETATM 2916 O O5  . WNT D 3 .   ? -14.76415 12.79718  41.00936 1.000 22.48998 ? 403 WNT A O5  1 
HETATM 2917 O O6  . WNT D 3 .   ? -16.49661 11.36073  40.64501 1.000 21.06126 ? 403 WNT A O6  1 
HETATM 2918 O O   . HOH E 4 .   ? 11.30267  20.19447  61.88502 1.000 32.43572 ? 501 HOH A O   1 
HETATM 2919 O O   . HOH E 4 .   ? 6.64893   11.59355  41.29951 1.000 58.15742 ? 502 HOH A O   1 
HETATM 2920 O O   . HOH E 4 .   ? 11.05126  20.59724  64.90609 1.000 59.62832 ? 503 HOH A O   1 
HETATM 2921 O O   . HOH E 4 .   ? 6.69723   -0.09737  53.17832 1.000 37.67694 ? 504 HOH A O   1 
HETATM 2922 O O   . HOH E 4 .   ? -6.92497  -0.35378  26.74376 1.000 56.17137 ? 505 HOH A O   1 
HETATM 2923 O O   . HOH E 4 .   ? -23.21034 1.71394   52.84659 1.000 48.95114 ? 506 HOH A O   1 
HETATM 2924 O O   . HOH E 4 .   ? -16.15636 -16.10042 53.27165 1.000 55.46410 ? 507 HOH A O   1 
HETATM 2925 O O   . HOH E 4 .   ? 11.36555  10.15923  42.39817 1.000 55.16528 ? 508 HOH A O   1 
HETATM 2926 O O   . HOH E 4 .   ? 6.65355   -1.26751  49.52443 1.000 26.10944 ? 509 HOH A O   1 
HETATM 2927 O O   . HOH E 4 .   ? 6.52970   -3.18355  56.56748 1.000 39.51181 ? 510 HOH A O   1 
HETATM 2928 O O   . HOH E 4 .   ? 12.95624  16.39078  68.55797 1.000 26.11673 ? 511 HOH A O   1 
HETATM 2929 O O   . HOH E 4 .   ? -2.50106  -8.48568  50.55246 1.000 58.90805 ? 512 HOH A O   1 
HETATM 2930 O O   . HOH E 4 .   ? -9.03225  21.95809  37.89353 1.000 59.96413 ? 513 HOH A O   1 
HETATM 2931 O O   . HOH E 4 .   ? -14.81681 9.51714   18.79635 1.000 36.51021 ? 514 HOH A O   1 
HETATM 2932 O O   . HOH E 4 .   ? 1.06621   18.11612  36.88308 1.000 55.99400 ? 515 HOH A O   1 
HETATM 2933 O O   . HOH E 4 .   ? -21.20715 17.43733  22.85434 1.000 45.92756 ? 516 HOH A O   1 
HETATM 2934 O O   . HOH E 4 .   ? -13.51104 18.77425  23.89455 1.000 46.03165 ? 517 HOH A O   1 
HETATM 2935 O O   . HOH E 4 .   ? -18.02504 19.06689  18.94127 1.000 47.35619 ? 518 HOH A O   1 
HETATM 2936 O O   . HOH E 4 .   ? -19.50125 1.23434   61.95347 1.000 32.88422 ? 519 HOH A O   1 
HETATM 2937 O O   . HOH E 4 .   ? -2.88756  -5.70054  38.33741 1.000 53.22084 ? 520 HOH A O   1 
HETATM 2938 O O   . HOH E 4 .   ? -18.60909 0.89582   64.56202 1.000 51.17711 ? 521 HOH A O   1 
HETATM 2939 O O   . HOH E 4 .   ? -17.55284 15.69868  46.16577 1.000 44.04360 ? 522 HOH A O   1 
HETATM 2940 O O   . HOH E 4 .   ? -2.65997  16.95760  42.12353 1.000 64.31031 ? 523 HOH A O   1 
HETATM 2941 O O   . HOH E 4 .   ? -9.05950  19.08281  55.01398 1.000 37.71155 ? 524 HOH A O   1 
HETATM 2942 O O   . HOH E 4 .   ? -15.49857 17.16315  65.53206 1.000 59.81936 ? 525 HOH A O   1 
HETATM 2943 O O   . HOH E 4 .   ? -10.98874 10.51545  38.38728 1.000 32.48281 ? 526 HOH A O   1 
HETATM 2944 O O   . HOH E 4 .   ? 20.28669  1.32623   66.98612 1.000 54.69100 ? 527 HOH A O   1 
HETATM 2945 O O   . HOH E 4 .   ? 8.78385   4.64830   65.14833 1.000 19.58625 ? 528 HOH A O   1 
HETATM 2946 O O   . HOH E 4 .   ? -12.10680 1.02378   35.70366 1.000 23.43518 ? 529 HOH A O   1 
HETATM 2947 O O   . HOH E 4 .   ? -15.44091 -9.41999  47.98464 1.000 32.63471 ? 530 HOH A O   1 
HETATM 2948 O O   . HOH E 4 .   ? -24.40812 5.01566   64.47611 1.000 55.81868 ? 531 HOH A O   1 
HETATM 2949 O O   . HOH E 4 .   ? 2.92393   7.17686   66.79164 1.000 29.25182 ? 532 HOH A O   1 
HETATM 2950 O O   . HOH E 4 .   ? -10.45377 6.40531   17.18387 1.000 31.75290 ? 533 HOH A O   1 
HETATM 2951 O O   . HOH E 4 .   ? 4.93153   -8.09018  63.12159 1.000 48.94182 ? 534 HOH A O   1 
HETATM 2952 O O   . HOH E 4 .   ? 9.28601   10.97269  66.23010 1.000 23.13777 ? 535 HOH A O   1 
HETATM 2953 O O   . HOH E 4 .   ? 12.83557  0.69652   51.19696 1.000 51.19776 ? 536 HOH A O   1 
HETATM 2954 O O   . HOH E 4 .   ? 8.12050   5.18133   53.49714 1.000 24.26706 ? 537 HOH A O   1 
HETATM 2955 O O   . HOH E 4 .   ? -15.86478 14.21610  62.93458 1.000 32.62742 ? 538 HOH A O   1 
HETATM 2956 O O   . HOH E 4 .   ? 1.17427   10.82099  69.98630 1.000 38.95056 ? 539 HOH A O   1 
HETATM 2957 O O   . HOH E 4 .   ? -6.41233  10.21812  33.83440 1.000 50.27930 ? 540 HOH A O   1 
HETATM 2958 O O   . HOH E 4 .   ? -14.10303 -9.72858  62.26416 1.000 31.73791 ? 541 HOH A O   1 
HETATM 2959 O O   . HOH E 4 .   ? -3.34630  -4.90993  67.92899 1.000 36.73028 ? 542 HOH A O   1 
HETATM 2960 O O   . HOH E 4 .   ? -7.71094  16.93329  76.08302 1.000 48.09258 ? 543 HOH A O   1 
HETATM 2961 O O   . HOH E 4 .   ? 10.33801  14.02931  79.23146 1.000 61.41818 ? 544 HOH A O   1 
HETATM 2962 O O   . HOH E 4 .   ? -1.60267  16.33480  44.39344 1.000 41.35154 ? 545 HOH A O   1 
HETATM 2963 O O   . HOH E 4 .   ? -16.29293 -6.38394  53.64257 1.000 30.33040 ? 546 HOH A O   1 
HETATM 2964 O O   . HOH E 4 .   ? 9.67450   10.69729  44.66126 1.000 43.33370 ? 547 HOH A O   1 
HETATM 2965 O O   . HOH E 4 .   ? 0.59450   1.18928   69.46391 1.000 35.22203 ? 548 HOH A O   1 
HETATM 2966 O O   . HOH E 4 .   ? -19.27237 7.54412   24.77994 1.000 30.81007 ? 549 HOH A O   1 
HETATM 2967 O O   . HOH E 4 .   ? -7.52904  -8.60565  54.68565 1.000 21.55629 ? 550 HOH A O   1 
HETATM 2968 O O   . HOH E 4 .   ? 25.94552  12.28940  63.61320 1.000 29.02643 ? 551 HOH A O   1 
HETATM 2969 O O   . HOH E 4 .   ? 12.38035  2.84272   69.24249 1.000 34.23916 ? 552 HOH A O   1 
HETATM 2970 O O   . HOH E 4 .   ? -31.98926 15.17635  32.29827 1.000 60.82173 ? 553 HOH A O   1 
HETATM 2971 O O   . HOH E 4 .   ? -13.09278 -5.07272  68.84838 1.000 37.41244 ? 554 HOH A O   1 
HETATM 2972 O O   . HOH E 4 .   ? 8.64280   19.55245  47.46401 1.000 52.71164 ? 555 HOH A O   1 
HETATM 2973 O O   . HOH E 4 .   ? 3.56153   3.11275   67.40513 1.000 40.75898 ? 556 HOH A O   1 
HETATM 2974 O O   . HOH E 4 .   ? -24.99743 17.42928  40.02126 1.000 48.08476 ? 557 HOH A O   1 
HETATM 2975 O O   . HOH E 4 .   ? -19.15183 -4.88398  50.21316 1.000 44.78631 ? 558 HOH A O   1 
HETATM 2976 O O   . HOH E 4 .   ? -8.92052  -7.68942  39.88906 1.000 44.97785 ? 559 HOH A O   1 
HETATM 2977 O O   . HOH E 4 .   ? -7.68272  14.63743  42.99192 1.000 34.64627 ? 560 HOH A O   1 
HETATM 2978 O O   . HOH E 4 .   ? -0.41124  25.47637  60.65174 1.000 44.87319 ? 561 HOH A O   1 
HETATM 2979 O O   . HOH E 4 .   ? 12.41071  -2.43537  44.66078 1.000 44.69873 ? 562 HOH A O   1 
HETATM 2980 O O   . HOH E 4 .   ? -23.86750 17.61089  25.87047 1.000 56.20739 ? 563 HOH A O   1 
HETATM 2981 O O   . HOH E 4 .   ? 5.64537   -0.68327  57.22888 1.000 23.91873 ? 564 HOH A O   1 
HETATM 2982 O O   . HOH E 4 .   ? -4.51492  -1.08725  31.65793 1.000 54.67163 ? 565 HOH A O   1 
HETATM 2983 O O   . HOH E 4 .   ? 5.74657   8.85487   69.43464 1.000 47.88412 ? 566 HOH A O   1 
HETATM 2984 O O   . HOH E 4 .   ? -8.30765  16.76369  45.21522 1.000 43.91536 ? 567 HOH A O   1 
HETATM 2985 O O   . HOH E 4 .   ? -7.55196  18.18097  53.13961 1.000 25.38802 ? 568 HOH A O   1 
HETATM 2986 O O   . HOH E 4 .   ? -5.14215  11.68806  35.75681 1.000 51.22405 ? 569 HOH A O   1 
HETATM 2987 O O   . HOH E 4 .   ? 0.12915   19.84560  64.15921 1.000 32.83851 ? 570 HOH A O   1 
HETATM 2988 O O   . HOH E 4 .   ? -19.89612 20.66447  53.85441 1.000 45.70041 ? 571 HOH A O   1 
HETATM 2989 O O   . HOH E 4 .   ? -1.16090  2.93954   25.65971 1.000 59.31516 ? 572 HOH A O   1 
HETATM 2990 O O   . HOH E 4 .   ? 10.76107  6.85185   67.85092 1.000 21.77935 ? 573 HOH A O   1 
HETATM 2991 O O   . HOH E 4 .   ? -10.35054 -6.30654  62.56558 1.000 20.23529 ? 574 HOH A O   1 
HETATM 2992 O O   . HOH E 4 .   ? -0.28629  -2.76112  70.87687 1.000 59.51443 ? 575 HOH A O   1 
HETATM 2993 O O   . HOH E 4 .   ? 8.78061   10.15921  70.56802 1.000 48.56968 ? 576 HOH A O   1 
HETATM 2994 O O   . HOH E 4 .   ? -9.96744  -10.51803 43.18358 1.000 52.52547 ? 577 HOH A O   1 
HETATM 2995 O O   . HOH E 4 .   ? -3.03082  18.70212  65.50316 1.000 48.92942 ? 578 HOH A O   1 
HETATM 2996 O O   . HOH E 4 .   ? -18.87569 -8.25472  48.93061 1.000 45.19481 ? 579 HOH A O   1 
HETATM 2997 O O   . HOH E 4 .   ? 3.40571   -5.90002  45.97558 1.000 33.34018 ? 580 HOH A O   1 
HETATM 2998 O O   . HOH E 4 .   ? 13.32918  6.68553   40.85975 1.000 64.52989 ? 581 HOH A O   1 
HETATM 2999 O O   . HOH E 4 .   ? -13.26854 -11.42293 48.00430 1.000 35.86945 ? 582 HOH A O   1 
HETATM 3000 O O   . HOH E 4 .   ? 10.93670  24.25397  54.24165 1.000 41.40092 ? 583 HOH A O   1 
HETATM 3001 O O   . HOH E 4 .   ? 14.94829  14.88994  67.15386 1.000 18.93923 ? 584 HOH A O   1 
HETATM 3002 O O   . HOH E 4 .   ? -17.06914 4.62810   38.12225 1.000 23.43866 ? 585 HOH A O   1 
HETATM 3003 O O   . HOH E 4 .   ? -14.98054 6.12424   16.60171 1.000 31.29132 ? 586 HOH A O   1 
HETATM 3004 O O   . HOH E 4 .   ? 12.09530  9.28533   71.86554 1.000 40.61309 ? 587 HOH A O   1 
HETATM 3005 O O   . HOH E 4 .   ? 2.39049   19.56994  66.03876 1.000 29.89184 ? 588 HOH A O   1 
HETATM 3006 O O   . HOH E 4 .   ? 10.40156  8.70830   59.27452 1.000 28.47416 ? 589 HOH A O   1 
HETATM 3007 O O   . HOH E 4 .   ? 14.26459  5.62410   52.32801 1.000 30.78748 ? 590 HOH A O   1 
HETATM 3008 O O   . HOH E 4 .   ? 7.91793   18.58055  74.92025 1.000 48.14939 ? 591 HOH A O   1 
HETATM 3009 O O   . HOH E 4 .   ? -13.73106 7.29207   67.80065 1.000 34.05405 ? 592 HOH A O   1 
HETATM 3010 O O   . HOH E 4 .   ? 6.09046   -2.39348  64.53075 1.000 50.99987 ? 593 HOH A O   1 
HETATM 3011 O O   . HOH E 4 .   ? 5.67780   18.05261  71.81951 1.000 33.24264 ? 594 HOH A O   1 
HETATM 3012 O O   . HOH E 4 .   ? -8.22029  12.67162  77.74197 1.000 43.15095 ? 595 HOH A O   1 
HETATM 3013 O O   . HOH E 4 .   ? 13.98402  14.22340  51.40719 1.000 28.39879 ? 596 HOH A O   1 
HETATM 3014 O O   . HOH E 4 .   ? -30.76032 14.45487  34.68752 1.000 47.36512 ? 597 HOH A O   1 
HETATM 3015 O O   . HOH E 4 .   ? -12.41331 6.68077   23.69037 1.000 22.72257 ? 598 HOH A O   1 
HETATM 3016 O O   . HOH E 4 .   ? 16.48615  20.82485  48.92313 1.000 47.33835 ? 599 HOH A O   1 
HETATM 3017 O O   . HOH E 4 .   ? -3.62072  -6.04284  63.74182 1.000 29.23422 ? 600 HOH A O   1 
HETATM 3018 O O   . HOH E 4 .   ? 13.36375  20.61249  75.09963 1.000 44.40315 ? 601 HOH A O   1 
HETATM 3019 O O   . HOH E 4 .   ? -22.69165 4.82717   37.13557 1.000 42.40945 ? 602 HOH A O   1 
HETATM 3020 O O   . HOH E 4 .   ? -6.67169  15.90063  63.69944 1.000 25.62649 ? 603 HOH A O   1 
HETATM 3021 O O   . HOH E 4 .   ? -23.54797 7.13477   38.39854 1.000 26.49484 ? 604 HOH A O   1 
HETATM 3022 O O   . HOH E 4 .   ? -10.14750 5.88794   41.04327 1.000 21.43731 ? 605 HOH A O   1 
HETATM 3023 O O   . HOH E 4 .   ? -18.18364 3.77079   25.13334 1.000 42.53156 ? 606 HOH A O   1 
HETATM 3024 O O   . HOH E 4 .   ? -17.50208 -6.84580  56.09452 1.000 38.80694 ? 607 HOH A O   1 
HETATM 3025 O O   . HOH E 4 .   ? -29.03472 12.96503  23.33328 1.000 49.36779 ? 608 HOH A O   1 
HETATM 3026 O O   . HOH E 4 .   ? 21.04484  22.72148  67.94413 1.000 29.69721 ? 609 HOH A O   1 
HETATM 3027 O O   . HOH E 4 .   ? 21.99288  18.42631  58.62691 1.000 27.18665 ? 610 HOH A O   1 
HETATM 3028 O O   . HOH E 4 .   ? -2.60588  9.13246   42.80267 1.000 26.29140 ? 611 HOH A O   1 
HETATM 3029 O O   . HOH E 4 .   ? -1.84252  13.15795  50.08622 1.000 18.26522 ? 612 HOH A O   1 
HETATM 3030 O O   . HOH E 4 .   ? 1.85472   14.47701  57.47239 1.000 17.44036 ? 613 HOH A O   1 
HETATM 3031 O O   . HOH E 4 .   ? -22.46560 10.13438  22.57646 0.798 36.35147 ? 614 HOH A O   1 
HETATM 3032 O O   . HOH E 4 .   ? -9.91301  -5.56066  49.37883 1.000 16.35381 ? 615 HOH A O   1 
HETATM 3033 O O   . HOH E 4 .   ? -2.38602  -4.15692  65.42824 1.000 29.69563 ? 616 HOH A O   1 
HETATM 3034 O O   . HOH E 4 .   ? 2.98803   -0.10729  64.01617 1.000 26.10353 ? 617 HOH A O   1 
HETATM 3035 O O   . HOH E 4 .   ? -4.96273  19.08411  25.97837 1.000 46.78467 ? 618 HOH A O   1 
HETATM 3036 O O   . HOH E 4 .   ? -6.08975  23.60134  60.40947 1.000 58.59935 ? 619 HOH A O   1 
HETATM 3037 O O   . HOH E 4 .   ? -2.28910  17.94840  20.98338 1.000 58.61046 ? 620 HOH A O   1 
HETATM 3038 O O   . HOH E 4 .   ? -7.98384  22.15356  25.39446 1.000 49.62218 ? 621 HOH A O   1 
HETATM 3039 O O   . HOH E 4 .   ? -26.48055 3.59605   47.66460 1.000 56.12355 ? 622 HOH A O   1 
HETATM 3040 O O   . HOH E 4 .   ? -11.04972 14.76644  21.93073 1.000 25.22442 ? 623 HOH A O   1 
HETATM 3041 O O   . HOH E 4 .   ? -5.00618  15.15798  58.70201 1.000 17.55454 ? 624 HOH A O   1 
HETATM 3042 O O   . HOH E 4 .   ? -2.23255  20.78535  28.37280 1.000 45.66322 ? 625 HOH A O   1 
HETATM 3043 O O   . HOH E 4 .   ? -19.83251 -7.30447  51.46810 1.000 49.35780 ? 626 HOH A O   1 
HETATM 3044 O O   . HOH E 4 .   ? 20.10137  18.93022  70.21369 1.000 48.78063 ? 627 HOH A O   1 
HETATM 3045 O O   . HOH E 4 .   ? -5.72683  3.85424   72.97687 1.000 30.15827 ? 628 HOH A O   1 
HETATM 3046 O O   . HOH E 4 .   ? -8.73612  16.64511  35.22470 1.000 38.67721 ? 629 HOH A O   1 
HETATM 3047 O O   . HOH E 4 .   ? -32.76427 9.51716   26.21421 1.000 58.01883 ? 630 HOH A O   1 
HETATM 3048 O O   . HOH E 4 .   ? 3.28309   0.74258   56.52559 1.000 20.37125 ? 631 HOH A O   1 
HETATM 3049 O O   . HOH E 4 .   ? 18.71520  -0.51661  68.75456 1.000 52.26284 ? 632 HOH A O   1 
HETATM 3050 O O   . HOH E 4 .   ? -22.69223 21.94686  60.80426 1.000 60.86670 ? 633 HOH A O   1 
HETATM 3051 O O   . HOH E 4 .   ? -32.08585 13.63572  27.44020 1.000 52.56049 ? 634 HOH A O   1 
HETATM 3052 O O   . HOH E 4 .   ? -12.17956 19.48304  55.18862 1.000 29.01920 ? 635 HOH A O   1 
HETATM 3053 O O   . HOH E 4 .   ? -5.75870  16.84048  44.30417 1.000 47.24091 ? 636 HOH A O   1 
HETATM 3054 O O   . HOH E 4 .   ? -2.69780  11.17584  9.35205  1.000 48.29327 ? 637 HOH A O   1 
HETATM 3055 O O   A HOH E 4 .   ? 11.47521  12.98259  48.67680 0.900 30.16078 ? 638 HOH A O   1 
HETATM 3056 O O   . HOH E 4 .   ? 19.84478  -0.21316  41.13572 1.000 64.64240 ? 639 HOH A O   1 
HETATM 3057 O O   . HOH E 4 .   ? 7.74160   20.77711  66.72922 1.000 54.32565 ? 640 HOH A O   1 
HETATM 3058 O O   . HOH E 4 .   ? -12.04158 -6.51590  43.81401 1.000 24.32007 ? 641 HOH A O   1 
HETATM 3059 O O   . HOH E 4 .   ? -5.71170  -9.03670  56.81651 1.000 23.96101 ? 642 HOH A O   1 
HETATM 3060 O O   . HOH E 4 .   ? -13.03415 3.90659   74.05485 1.000 38.33209 ? 643 HOH A O   1 
HETATM 3061 O O   . HOH E 4 .   ? -24.50767 15.60965  45.55875 1.000 49.46527 ? 644 HOH A O   1 
HETATM 3062 O O   . HOH E 4 .   ? -8.35628  0.67875   24.74861 1.000 54.79000 ? 645 HOH A O   1 
HETATM 3063 O O   . HOH E 4 .   ? 3.35882   -7.14525  52.83257 1.000 56.70820 ? 646 HOH A O   1 
HETATM 3064 O O   . HOH E 4 .   ? 6.80209   6.72881   66.25854 1.000 25.77843 ? 647 HOH A O   1 
HETATM 3065 O O   . HOH E 4 .   ? 2.61775   9.97468   53.10282 1.000 18.71696 ? 648 HOH A O   1 
HETATM 3066 O O   . HOH E 4 .   ? -26.89860 15.49380  39.60052 1.000 46.31559 ? 649 HOH A O   1 
HETATM 3067 O O   . HOH E 4 .   ? -2.27541  -5.78736  50.13763 1.000 20.99457 ? 650 HOH A O   1 
HETATM 3068 O O   . HOH E 4 .   ? -11.04520 18.80967  57.86037 1.000 32.32499 ? 651 HOH A O   1 
HETATM 3069 O O   . HOH E 4 .   ? -20.74783 0.88869   43.43209 1.000 43.48884 ? 652 HOH A O   1 
HETATM 3070 O O   . HOH E 4 .   ? -8.59576  -0.18678  73.94111 1.000 40.69189 ? 653 HOH A O   1 
HETATM 3071 O O   . HOH E 4 .   ? -11.08314 0.76777   38.71605 1.000 31.84817 ? 654 HOH A O   1 
HETATM 3072 O O   . HOH E 4 .   ? -12.97011 12.52350  11.61947 1.000 20.04152 ? 655 HOH A O   1 
HETATM 3073 O O   . HOH E 4 .   ? -9.34420  -12.46108 49.81415 1.000 27.81119 ? 656 HOH A O   1 
HETATM 3074 O O   . HOH E 4 .   ? -20.09041 0.78513   40.60925 1.000 51.71643 ? 657 HOH A O   1 
HETATM 3075 O O   . HOH E 4 .   ? 4.79021   -5.61666  50.18091 1.000 37.06904 ? 658 HOH A O   1 
HETATM 3076 O O   . HOH E 4 .   ? -5.18476  13.45799  34.22409 1.000 45.74960 ? 659 HOH A O   1 
HETATM 3077 O O   . HOH E 4 .   ? 6.72352   18.45767  53.51470 1.000 25.77123 ? 660 HOH A O   1 
HETATM 3078 O O   . HOH E 4 .   ? -14.65585 -0.73683  67.22818 1.000 38.46471 ? 661 HOH A O   1 
HETATM 3079 O O   . HOH E 4 .   ? 24.66735  16.84908  50.35083 1.000 46.50344 ? 662 HOH A O   1 
HETATM 3080 O O   . HOH E 4 .   ? -13.00514 -0.25550  40.48281 1.000 21.07050 ? 663 HOH A O   1 
HETATM 3081 O O   . HOH E 4 .   ? -0.94999  8.57156   50.04073 1.000 15.67152 ? 664 HOH A O   1 
HETATM 3082 O O   . HOH E 4 .   ? -25.62880 7.63972   46.13882 1.000 53.11158 ? 665 HOH A O   1 
HETATM 3083 O O   . HOH E 4 .   ? -20.02063 8.60721   68.09041 1.000 37.98868 ? 666 HOH A O   1 
HETATM 3084 O O   . HOH E 4 .   ? 23.26153  17.94494  64.87066 1.000 27.84215 ? 667 HOH A O   1 
HETATM 3085 O O   . HOH E 4 .   ? -10.02368 9.07240   73.89968 1.000 38.49531 ? 668 HOH A O   1 
HETATM 3086 O O   . HOH E 4 .   ? -16.81853 0.38200   22.64888 1.000 50.32709 ? 669 HOH A O   1 
HETATM 3087 O O   . HOH E 4 .   ? -20.83501 0.17560   67.20043 1.000 49.63663 ? 670 HOH A O   1 
HETATM 3088 O O   . HOH E 4 .   ? -2.39735  16.39429  58.51208 1.000 19.40422 ? 671 HOH A O   1 
HETATM 3089 O O   . HOH E 4 .   ? -1.54220  25.10780  57.12989 1.000 52.12523 ? 672 HOH A O   1 
HETATM 3090 O O   . HOH E 4 .   ? -17.40499 0.26232   31.24205 1.000 55.41410 ? 673 HOH A O   1 
HETATM 3091 O O   . HOH E 4 .   ? -15.74325 9.11544   22.31688 1.000 25.00872 ? 674 HOH A O   1 
HETATM 3092 O O   . HOH E 4 .   ? -31.03013 15.30346  29.66007 1.000 53.74011 ? 675 HOH A O   1 
HETATM 3093 O O   . HOH E 4 .   ? 0.44545   -1.89992  53.24463 1.000 17.84777 ? 676 HOH A O   1 
HETATM 3094 O O   . HOH E 4 .   ? -18.97650 2.31761   28.27797 1.000 52.48633 ? 677 HOH A O   1 
HETATM 3095 O O   . HOH E 4 .   ? 11.02155  21.24391  72.79071 1.000 37.08139 ? 678 HOH A O   1 
HETATM 3096 O O   . HOH E 4 .   ? -15.30189 14.55080  22.61904 1.000 57.12322 ? 679 HOH A O   1 
HETATM 3097 O O   . HOH E 4 .   ? 0.93467   20.17617  48.89267 1.000 28.21460 ? 680 HOH A O   1 
HETATM 3098 O O   . HOH E 4 .   ? -13.17825 0.08059   32.59882 1.000 47.87910 ? 681 HOH A O   1 
HETATM 3099 O O   . HOH E 4 .   ? -15.53464 -14.63659 49.52587 1.000 43.90496 ? 682 HOH A O   1 
HETATM 3100 O O   . HOH E 4 .   ? 2.00846   -2.61707  63.82253 1.000 33.13280 ? 683 HOH A O   1 
HETATM 3101 O O   . HOH E 4 .   ? 13.32208  5.79761   61.28836 1.000 25.35149 ? 684 HOH A O   1 
HETATM 3102 O O   . HOH E 4 .   ? -9.21755  4.65400   18.23336 1.000 33.97428 ? 685 HOH A O   1 
HETATM 3103 O O   . HOH E 4 .   ? -20.37025 19.46538  44.28458 1.000 52.97404 ? 686 HOH A O   1 
HETATM 3104 O O   . HOH E 4 .   ? -22.20195 18.16366  62.61655 1.000 31.03839 ? 687 HOH A O   1 
HETATM 3105 O O   . HOH E 4 .   ? 3.16573   16.14856  75.88982 1.000 39.36670 ? 688 HOH A O   1 
HETATM 3106 O O   . HOH E 4 .   ? 10.77818  4.34107   53.49312 1.000 27.28397 ? 689 HOH A O   1 
HETATM 3107 O O   . HOH E 4 .   ? 8.66167   -4.07947  58.11545 1.000 52.20104 ? 690 HOH A O   1 
HETATM 3108 O O   . HOH E 4 .   ? -11.36801 18.79715  17.35921 1.000 33.80976 ? 691 HOH A O   1 
HETATM 3109 O O   . HOH E 4 .   ? 8.31496   5.26618   50.83002 1.000 24.01975 ? 692 HOH A O   1 
HETATM 3110 O O   . HOH E 4 .   ? 18.63967  1.17715   64.48127 1.000 46.81349 ? 693 HOH A O   1 
HETATM 3111 O O   . HOH E 4 .   ? 14.77601  23.48638  62.95620 1.000 31.40202 ? 694 HOH A O   1 
HETATM 3112 O O   . HOH E 4 .   ? 2.07569   -7.45732  44.51390 1.000 42.28571 ? 695 HOH A O   1 
HETATM 3113 O O   . HOH E 4 .   ? 3.84591   5.55215   70.29129 1.000 52.57455 ? 696 HOH A O   1 
HETATM 3114 O O   . HOH E 4 .   ? -16.35032 0.60311   42.28693 1.000 24.08168 ? 697 HOH A O   1 
HETATM 3115 O O   . HOH E 4 .   ? 11.30114  12.53905  45.91502 1.000 37.66228 ? 698 HOH A O   1 
HETATM 3116 O O   . HOH E 4 .   ? -0.37737  -5.94559  54.39948 1.000 25.03894 ? 699 HOH A O   1 
HETATM 3117 O O   . HOH E 4 .   ? -24.23234 14.16883  43.36365 1.000 38.36063 ? 700 HOH A O   1 
HETATM 3118 O O   . HOH E 4 .   ? -1.73078  15.45936  17.47592 1.000 55.12028 ? 701 HOH A O   1 
HETATM 3119 O O   . HOH E 4 .   ? -15.39730 12.99898  65.50799 1.000 44.21134 ? 702 HOH A O   1 
HETATM 3120 O O   . HOH E 4 .   ? 18.92294  4.64570   55.94672 1.000 42.68816 ? 703 HOH A O   1 
HETATM 3121 O O   . HOH E 4 .   ? -13.06768 12.03234  68.45378 1.000 33.95976 ? 704 HOH A O   1 
HETATM 3122 O O   . HOH E 4 .   ? -8.11257  -9.95016  64.14496 1.000 36.62492 ? 705 HOH A O   1 
HETATM 3123 O O   . HOH E 4 .   ? -11.13647 2.41085   18.55711 1.000 40.39114 ? 706 HOH A O   1 
HETATM 3124 O O   . HOH E 4 .   ? -8.15645  16.78709  50.90976 1.000 20.09575 ? 707 HOH A O   1 
HETATM 3125 O O   . HOH E 4 .   ? -10.03785 8.11747   39.56968 1.000 25.83304 ? 708 HOH A O   1 
HETATM 3126 O O   . HOH E 4 .   ? -18.19405 -9.64642  54.68028 1.000 55.06913 ? 709 HOH A O   1 
HETATM 3127 O O   . HOH E 4 .   ? 19.36585  7.89820   52.16537 1.000 29.83922 ? 710 HOH A O   1 
HETATM 3128 O O   . HOH E 4 .   ? 16.15645  3.46332   71.03522 1.000 29.46140 ? 711 HOH A O   1 
HETATM 3129 O O   . HOH E 4 .   ? -16.68085 7.02183   23.84772 1.000 29.92054 ? 712 HOH A O   1 
HETATM 3130 O O   . HOH E 4 .   ? -16.69806 2.29608   40.19772 1.000 26.05493 ? 713 HOH A O   1 
HETATM 3131 O O   . HOH E 4 .   ? 23.29000  4.15775   69.17332 1.000 56.15000 ? 714 HOH A O   1 
HETATM 3132 O O   A HOH E 4 .   ? 0.95782   13.15058  50.55552 0.685 22.80319 ? 715 HOH A O   1 
HETATM 3133 O O   B HOH E 4 .   ? 3.09014   13.52997  44.20259 0.315 55.15588 ? 715 HOH A O   1 
HETATM 3134 O O   . HOH E 4 .   ? -4.82736  -8.11239  65.21105 1.000 61.93534 ? 716 HOH A O   1 
HETATM 3135 O O   . HOH E 4 .   ? -14.37663 -5.44066  45.15197 1.000 32.50504 ? 717 HOH A O   1 
HETATM 3136 O O   . HOH E 4 .   ? 16.01373  5.90117   72.51240 1.000 31.22906 ? 718 HOH A O   1 
HETATM 3137 O O   . HOH E 4 .   ? -18.12053 1.89485   47.51072 1.000 34.26010 ? 719 HOH A O   1 
HETATM 3138 O O   . HOH E 4 .   ? -21.12189 5.45994   24.28233 1.000 38.49938 ? 720 HOH A O   1 
HETATM 3139 O O   . HOH E 4 .   ? -11.88364 13.53709  70.38596 1.000 35.45517 ? 721 HOH A O   1 
HETATM 3140 O O   . HOH E 4 .   ? -20.80338 5.28657   31.25427 1.000 46.75105 ? 722 HOH A O   1 
HETATM 3141 O O   . HOH E 4 .   ? -4.40677  1.28292   73.27893 1.000 53.09774 ? 723 HOH A O   1 
HETATM 3142 O O   . HOH E 4 .   ? 13.32706  6.68762   57.14062 1.000 35.97176 ? 724 HOH A O   1 
HETATM 3143 O O   . HOH E 4 .   ? -3.41076  7.94282   74.37528 1.000 37.43760 ? 725 HOH A O   1 
HETATM 3144 O O   . HOH E 4 .   ? -26.81317 8.58235   39.76539 1.000 51.14610 ? 726 HOH A O   1 
HETATM 3145 O O   . HOH E 4 .   ? -8.05256  23.08989  53.15867 1.000 45.08710 ? 727 HOH A O   1 
HETATM 3146 O O   . HOH E 4 .   ? 0.65962   12.47271  18.86500 1.000 53.78765 ? 728 HOH A O   1 
HETATM 3147 O O   . HOH E 4 .   ? 23.96110  9.29017   65.73928 1.000 28.62728 ? 729 HOH A O   1 
HETATM 3148 O O   . HOH E 4 .   ? 0.37461   -5.48048  50.12159 1.000 21.57549 ? 730 HOH A O   1 
HETATM 3149 O O   . HOH E 4 .   ? -3.99642  -10.66716 55.29963 1.000 50.30992 ? 731 HOH A O   1 
HETATM 3150 O O   . HOH E 4 .   ? -0.55881  -4.90990  69.48790 1.000 60.23180 ? 732 HOH A O   1 
HETATM 3151 O O   . HOH E 4 .   ? 5.84979   3.38054   38.37432 1.000 40.69552 ? 733 HOH A O   1 
HETATM 3152 O O   . HOH E 4 .   ? -20.17194 10.47776  24.09245 1.000 46.88585 ? 734 HOH A O   1 
HETATM 3153 O O   . HOH E 4 .   ? -21.38784 5.78092   66.64934 1.000 36.28487 ? 735 HOH A O   1 
HETATM 3154 O O   . HOH E 4 .   ? 17.64251  3.10255   47.93108 1.000 47.08728 ? 736 HOH A O   1 
HETATM 3155 O O   . HOH E 4 .   ? -8.90872  -11.96896 46.73244 1.000 36.48626 ? 737 HOH A O   1 
HETATM 3156 O O   . HOH E 4 .   ? 10.33261  -0.44179  68.66321 1.000 59.06506 ? 738 HOH A O   1 
HETATM 3157 O O   . HOH E 4 .   ? 18.77423  2.24655   71.51041 1.000 49.95593 ? 739 HOH A O   1 
HETATM 3158 O O   . HOH E 4 .   ? -17.46719 -1.15783  50.90355 1.000 32.12593 ? 740 HOH A O   1 
HETATM 3159 O O   . HOH E 4 .   ? -0.40647  -6.81785  63.76827 1.000 48.39875 ? 741 HOH A O   1 
HETATM 3160 O O   . HOH E 4 .   ? 5.06425   -1.92606  53.84917 1.000 35.59732 ? 742 HOH A O   1 
HETATM 3161 O O   . HOH E 4 .   ? -29.12687 9.37856   38.86800 1.000 50.46020 ? 743 HOH A O   1 
HETATM 3162 O O   . HOH E 4 .   ? -6.76556  17.55462  68.04713 1.000 50.24521 ? 744 HOH A O   1 
HETATM 3163 O O   . HOH E 4 .   ? 5.94614   19.95055  28.47554 1.000 57.68869 ? 745 HOH A O   1 
HETATM 3164 O O   . HOH E 4 .   ? 13.76408  24.06900  60.41764 1.000 52.64715 ? 746 HOH A O   1 
HETATM 3165 O O   . HOH E 4 .   ? -13.44053 -11.68918 65.74829 1.000 56.10112 ? 747 HOH A O   1 
HETATM 3166 O O   . HOH E 4 .   ? 19.02824  7.16354   54.93640 1.000 30.63599 ? 748 HOH A O   1 
HETATM 3167 O O   . HOH E 4 .   ? -13.84652 19.70091  43.70042 1.000 51.02806 ? 749 HOH A O   1 
HETATM 3168 O O   . HOH E 4 .   ? -11.13996 17.74903  21.17079 1.000 46.16024 ? 750 HOH A O   1 
HETATM 3169 O O   . HOH E 4 .   ? -3.19548  4.99171   71.53051 0.834 40.54564 ? 751 HOH A O   1 
HETATM 3170 O O   . HOH E 4 .   ? -0.47375  8.15456   73.29532 1.000 33.71582 ? 752 HOH A O   1 
HETATM 3171 O O   . HOH E 4 .   ? 23.18765  18.16894  67.95320 1.000 45.96362 ? 753 HOH A O   1 
HETATM 3172 O O   . HOH E 4 .   ? -26.80292 23.10984  36.70463 1.000 64.41656 ? 754 HOH A O   1 
HETATM 3173 O O   . HOH E 4 .   ? -6.58400  22.52366  32.56820 1.000 61.30878 ? 755 HOH A O   1 
HETATM 3174 O O   . HOH E 4 .   ? -5.50077  8.75263   14.50986 1.000 47.29550 ? 756 HOH A O   1 
HETATM 3175 O O   . HOH E 4 .   ? -16.59422 0.81174   66.33693 0.871 42.56059 ? 757 HOH A O   1 
HETATM 3176 O O   . HOH E 4 .   ? -10.69887 -6.13481  71.37179 1.000 61.54806 ? 758 HOH A O   1 
HETATM 3177 O O   . HOH E 4 .   ? 10.78069  1.97534   54.21083 1.000 59.48072 ? 759 HOH A O   1 
HETATM 3178 O O   . HOH E 4 .   ? -10.25887 -8.09403  66.82375 1.000 38.39081 ? 760 HOH A O   1 
HETATM 3179 O O   . HOH E 4 .   ? -15.95840 -7.21121  46.42093 1.000 30.23050 ? 761 HOH A O   1 
HETATM 3180 O O   . HOH E 4 .   ? -5.80885  -6.01363  38.80917 1.000 53.54562 ? 762 HOH A O   1 
HETATM 3181 O O   . HOH E 4 .   ? 13.61425  -0.65499  62.02761 1.000 48.74647 ? 763 HOH A O   1 
HETATM 3182 O O   . HOH E 4 .   ? -27.24963 14.27524  52.31350 1.000 33.15641 ? 764 HOH A O   1 
HETATM 3183 O O   . HOH E 4 .   ? -4.83246  -3.56667  69.91232 1.000 35.90165 ? 765 HOH A O   1 
HETATM 3184 O O   . HOH E 4 .   ? -7.26525  14.50763  35.63058 1.000 40.18003 ? 766 HOH A O   1 
HETATM 3185 O O   . HOH E 4 .   ? -6.69097  3.23414   17.80411 1.000 43.33236 ? 767 HOH A O   1 
HETATM 3186 O O   . HOH E 4 .   ? 8.68732   0.52101   54.98042 1.000 43.09485 ? 768 HOH A O   1 
HETATM 3187 O O   . HOH E 4 .   ? -1.61116  20.42294  52.27098 1.000 36.04556 ? 769 HOH A O   1 
HETATM 3188 O O   . HOH E 4 .   ? 13.90612  4.21747   59.11190 1.000 41.70991 ? 770 HOH A O   1 
HETATM 3189 O O   . HOH E 4 .   ? -16.80363 10.98438  73.71005 1.000 62.24128 ? 771 HOH A O   1 
HETATM 3190 O O   . HOH E 4 .   ? -29.60222 6.20844   24.32905 1.000 55.44366 ? 772 HOH A O   1 
HETATM 3191 O O   . HOH E 4 .   ? -18.34354 -9.06547  59.06232 1.000 52.54864 ? 773 HOH A O   1 
HETATM 3192 O O   . HOH E 4 .   ? -7.23687  19.04153  48.95689 1.000 50.58393 ? 774 HOH A O   1 
HETATM 3193 O O   . HOH E 4 .   ? 2.68986   -0.69696  54.15710 1.000 20.17516 ? 775 HOH A O   1 
HETATM 3194 O O   . HOH E 4 .   ? -27.04674 15.19258  47.91772 1.000 59.65771 ? 776 HOH A O   1 
HETATM 3195 O O   . HOH E 4 .   ? -20.87624 1.75941   34.40870 1.000 55.63453 ? 777 HOH A O   1 
HETATM 3196 O O   . HOH E 4 .   ? -17.42308 -12.74636 50.49175 1.000 57.17473 ? 778 HOH A O   1 
HETATM 3197 O O   . HOH E 4 .   ? 1.23693   -4.40927  52.63148 1.000 23.25215 ? 779 HOH A O   1 
HETATM 3198 O O   . HOH E 4 .   ? -11.76674 22.25494  55.10928 1.000 45.76769 ? 780 HOH A O   1 
HETATM 3199 O O   . HOH E 4 .   ? 12.64295  5.42078   54.84269 1.000 36.48919 ? 781 HOH A O   1 
HETATM 3200 O O   . HOH E 4 .   ? 3.81008   0.65550   66.61896 1.000 29.42735 ? 782 HOH A O   1 
HETATM 3201 O O   . HOH E 4 .   ? 6.41116   -3.51777  47.81598 1.000 42.04299 ? 783 HOH A O   1 
HETATM 3202 O O   . HOH E 4 .   ? -16.95007 0.82723   37.97342 1.000 45.82221 ? 784 HOH A O   1 
HETATM 3203 O O   . HOH E 4 .   ? -23.42038 3.61161   35.02477 1.000 53.06388 ? 785 HOH A O   1 
HETATM 3204 O O   . HOH E 4 .   ? -25.50339 22.40359  23.36713 1.000 60.60330 ? 786 HOH A O   1 
HETATM 3205 O O   . HOH E 4 .   ? -17.88224 0.04855   34.04387 1.000 65.84075 ? 787 HOH A O   1 
HETATM 3206 O O   . HOH E 4 .   ? 0.95174   -8.03955  50.87158 1.000 57.14926 ? 788 HOH A O   1 
HETATM 3207 O O   . HOH E 4 .   ? -18.21074 0.24549   68.27169 0.788 46.73438 ? 789 HOH A O   1 
HETATM 3208 O O   . HOH E 4 .   ? 27.51955  19.78270  51.67713 1.000 50.62032 ? 790 HOH A O   1 
HETATM 3209 O O   . HOH E 4 .   ? 0.20951   -4.30753  65.12636 1.000 33.78709 ? 791 HOH A O   1 
HETATM 3210 O O   . HOH E 4 .   ? 20.31358  0.39398   62.61919 1.000 49.96587 ? 792 HOH A O   1 
HETATM 3211 O O   . HOH E 4 .   ? 8.19691   13.10773  43.87718 1.000 60.71189 ? 793 HOH A O   1 
HETATM 3212 O O   . HOH E 4 .   ? -1.27874  21.72174  65.41541 1.000 58.21827 ? 794 HOH A O   1 
HETATM 3213 O O   . HOH E 4 .   ? 4.60503   22.62217  65.46626 1.000 56.43453 ? 795 HOH A O   1 
HETATM 3214 O O   . HOH E 4 .   ? 6.88000   17.97537  26.71637 1.000 55.00102 ? 796 HOH A O   1 
HETATM 3215 O O   . HOH E 4 .   ? -10.59593 -8.63559  64.04265 1.000 27.65727 ? 797 HOH A O   1 
HETATM 3216 O O   . HOH E 4 .   ? 2.89820   -0.59389  68.57065 1.000 52.37479 ? 798 HOH A O   1 
HETATM 3217 O O   . HOH E 4 .   ? -17.59511 -3.98032  52.43290 1.000 36.98703 ? 799 HOH A O   1 
HETATM 3218 O O   . HOH E 4 .   ? -17.71637 19.87019  62.58942 1.000 54.44285 ? 800 HOH A O   1 
HETATM 3219 O O   . HOH E 4 .   ? -7.81015  0.86080   76.42735 1.000 58.98161 ? 801 HOH A O   1 
HETATM 3220 O O   . HOH E 4 .   ? -11.33760 15.92552  68.99924 1.000 60.03460 ? 802 HOH A O   1 
HETATM 3221 O O   . HOH E 4 .   ? -22.00073 4.14440   43.72558 1.000 56.91138 ? 803 HOH A O   1 
HETATM 3222 O O   . HOH E 4 .   ? 11.69011  22.14604  70.31866 1.000 53.19629 ? 804 HOH A O   1 
HETATM 3223 O O   . HOH E 4 .   ? -23.35016 15.92068  65.23228 1.000 50.35092 ? 805 HOH A O   1 
HETATM 3224 O O   . HOH E 4 .   ? 2.85939   11.23470  50.54088 1.000 43.57647 ? 806 HOH A O   1 
HETATM 3225 O O   . HOH E 4 .   ? -29.55331 13.53466  47.35836 1.000 57.11239 ? 807 HOH A O   1 
HETATM 3226 O O   . HOH E 4 .   ? 7.50976   18.48356  23.50000 1.000 53.40642 ? 808 HOH A O   1 
HETATM 3227 O O   . HOH E 4 .   ? -14.85315 9.92963   67.86737 1.000 39.46469 ? 809 HOH A O   1 
HETATM 3228 O O   . HOH E 4 .   ? -9.61274  20.04781  47.65912 1.000 58.63025 ? 810 HOH A O   1 
HETATM 3229 O O   . HOH E 4 .   ? -6.73902  -0.59695  72.22765 1.000 45.61650 ? 811 HOH A O   1 
HETATM 3230 O O   . HOH E 4 .   ? -17.40743 -1.88786  41.71942 1.000 48.94078 ? 812 HOH A O   1 
HETATM 3231 O O   . HOH E 4 .   ? -15.46050 -5.54519  42.16530 1.000 43.77706 ? 813 HOH A O   1 
HETATM 3232 O O   . HOH E 4 .   ? -7.11690  -2.24870  70.40207 1.000 32.88550 ? 814 HOH A O   1 
HETATM 3233 O O   . HOH E 4 .   ? 12.48830  7.42041   59.45746 1.000 28.43783 ? 815 HOH A O   1 
HETATM 3234 O O   . HOH E 4 .   ? -1.11536  13.67619  14.64577 1.000 50.55204 ? 816 HOH A O   1 
HETATM 3235 O O   . HOH E 4 .   ? -15.85881 -11.48693 63.05708 1.000 57.88714 ? 817 HOH A O   1 
HETATM 3236 O O   . HOH E 4 .   ? -1.13007  4.13320   71.95629 1.000 49.77325 ? 818 HOH A O   1 
HETATM 3237 O O   . HOH E 4 .   ? 5.95816   4.77280   67.68552 1.000 55.06000 ? 819 HOH A O   1 
HETATM 3238 O O   . HOH E 4 .   ? 0.95308   16.84448  20.90253 1.000 56.99583 ? 820 HOH A O   1 
HETATM 3239 O O   . HOH E 4 .   ? 9.95990   5.80800   70.28062 1.000 46.53787 ? 821 HOH A O   1 
HETATM 3240 O O   . HOH E 4 .   ? -23.60876 6.86039   67.23210 1.000 49.38820 ? 822 HOH A O   1 
HETATM 3241 O O   . HOH E 4 .   ? -8.77859  6.63249   74.80927 1.000 45.78680 ? 823 HOH A O   1 
HETATM 3242 O O   . HOH E 4 .   ? 13.69983  1.88462   71.08914 1.000 48.25547 ? 824 HOH A O   1 
HETATM 3243 O O   . HOH E 4 .   ? -18.22221 11.10761  21.39273 1.000 57.95665 ? 825 HOH A O   1 
HETATM 3244 O O   . HOH E 4 .   ? 4.37417   18.94747  74.02700 1.000 61.21474 ? 826 HOH A O   1 
HETATM 3245 O O   . HOH E 4 .   ? -14.99670 -1.10626  38.91412 1.000 38.60147 ? 827 HOH A O   1 
HETATM 3246 O O   . HOH E 4 .   ? -31.10467 8.52735   24.01793 1.000 58.74042 ? 828 HOH A O   1 
HETATM 3247 O O   . HOH E 4 .   ? 27.46899  16.77852  52.12994 1.000 60.54790 ? 829 HOH A O   1 
HETATM 3248 O O   . HOH E 4 .   ? -11.69175 -8.96488  42.99541 1.000 44.39100 ? 830 HOH A O   1 
HETATM 3249 O O   . HOH E 4 .   ? 10.40533  25.57102  51.58785 1.000 49.94265 ? 831 HOH A O   1 
HETATM 3250 O O   . HOH E 4 .   ? 6.48664   0.21428   66.73439 1.000 35.41008 ? 832 HOH A O   1 
HETATM 3251 O O   . HOH E 4 .   ? 1.58521   8.83984   75.15012 1.000 53.35141 ? 833 HOH A O   1 
HETATM 3252 O O   . HOH E 4 .   ? -8.83027  21.92199  55.51028 1.000 46.53480 ? 834 HOH A O   1 
HETATM 3253 O O   . HOH E 4 .   ? 8.65968   8.53453   67.34448 1.000 25.27099 ? 835 HOH A O   1 
HETATM 3254 O O   . HOH E 4 .   ? -7.97020  0.52818   17.64389 1.000 66.61913 ? 836 HOH A O   1 
HETATM 3255 O O   . HOH E 4 .   ? -6.43594  5.79081   74.62216 1.000 52.00286 ? 837 HOH A O   1 
HETATM 3256 O O   . HOH E 4 .   ? -2.40864  19.79577  67.66074 1.000 46.87864 ? 838 HOH A O   1 
HETATM 3257 O O   . HOH E 4 .   ? -12.21541 -10.45416 63.66065 1.000 38.89810 ? 839 HOH A O   1 
HETATM 3258 O O   . HOH E 4 .   ? -3.62670  20.85409  48.30844 1.000 46.10333 ? 840 HOH A O   1 
HETATM 3259 O O   . HOH E 4 .   ? 7.79564   2.63371   66.75386 1.000 36.75802 ? 841 HOH A O   1 
HETATM 3260 O O   . HOH E 4 .   ? -21.17352 -7.19621  53.59257 1.000 58.91435 ? 842 HOH A O   1 
HETATM 3261 O O   . HOH E 4 .   ? 8.71751   -3.27584  65.33829 1.000 63.60535 ? 843 HOH A O   1 
HETATM 3262 O O   . HOH E 4 .   ? 11.23240  21.43964  47.43768 1.000 55.70521 ? 844 HOH A O   1 
HETATM 3263 O O   . HOH E 4 .   ? 20.87771  20.61827  54.55823 1.000 54.73136 ? 845 HOH A O   1 
HETATM 3264 O O   . HOH E 4 .   ? -8.58128  -4.20160  71.92194 1.000 37.80126 ? 846 HOH A O   1 
HETATM 3265 O O   . HOH E 4 .   ? -29.97864 10.46405  22.32768 1.000 60.00668 ? 847 HOH A O   1 
HETATM 3266 O O   . HOH E 4 .   ? -5.08283  22.07384  25.80783 1.000 56.88214 ? 848 HOH A O   1 
HETATM 3267 O O   . HOH E 4 .   ? -1.01392  -9.50292  48.16036 1.000 53.06502 ? 849 HOH A O   1 
HETATM 3268 O O   . HOH E 4 .   ? 11.41447  7.13794   72.57292 1.000 45.81610 ? 850 HOH A O   1 
HETATM 3269 O O   . HOH E 4 .   ? 9.19615   -2.42141  55.56045 1.000 50.96911 ? 851 HOH A O   1 
HETATM 3270 O O   . HOH E 4 .   ? 21.08003  20.42417  57.46105 1.000 53.12029 ? 852 HOH A O   1 
HETATM 3271 O O   . HOH E 4 .   ? -9.72176  -2.38995  74.16062 1.000 49.03049 ? 853 HOH A O   1 
HETATM 3272 O O   . HOH E 4 .   ? 13.62962  23.52275  53.88795 1.000 40.45514 ? 854 HOH A O   1 
HETATM 3273 O O   . HOH E 4 .   ? -28.01950 13.36142  41.02746 1.000 54.54058 ? 855 HOH A O   1 
HETATM 3274 O O   . HOH E 4 .   ? 23.44854  20.85387  67.65738 1.000 52.34370 ? 856 HOH A O   1 
HETATM 3275 O O   . HOH E 4 .   ? 0.77709   15.02482  18.54708 1.000 49.43382 ? 857 HOH A O   1 
HETATM 3276 O O   . HOH E 4 .   ? 0.56515   10.12016  16.01791 1.000 57.93913 ? 858 HOH A O   1 
HETATM 3277 O O   . HOH E 4 .   ? 9.73848   26.42072  47.31834 1.000 57.06593 ? 859 HOH A O   1 
HETATM 3278 O O   . HOH E 4 .   ? -5.54197  19.76776  51.56906 1.000 53.37924 ? 860 HOH A O   1 
HETATM 3279 O O   . HOH E 4 .   ? -16.99486 10.80074  17.29928 1.000 56.73499 ? 861 HOH A O   1 
HETATM 3280 O O   . HOH E 4 .   ? -9.36795  15.38911  78.23660 1.000 58.03474 ? 862 HOH A O   1 
HETATM 3281 O O   . HOH E 4 .   ? -7.99300  -9.18940  68.03650 1.000 50.20775 ? 863 HOH A O   1 
HETATM 3282 O O   . HOH E 4 .   ? -18.91265 7.63514   17.77982 1.000 60.86784 ? 864 HOH A O   1 
HETATM 3283 O O   . HOH E 4 .   ? 21.42846  22.86703  53.69605 1.000 56.27799 ? 865 HOH A O   1 
HETATM 3284 O O   . HOH E 4 .   ? -8.24725  -12.34962 63.13434 1.000 44.89981 ? 866 HOH A O   1 
HETATM 3285 O O   . HOH E 4 .   ? -7.87500  23.41352  57.91423 1.000 56.47118 ? 867 HOH A O   1 
HETATM 3286 O O   . HOH E 4 .   ? 1.82635   20.43707  73.16995 1.000 57.64178 ? 868 HOH A O   1 
HETATM 3287 O O   . HOH E 4 .   ? -0.74791  19.57346  69.90935 1.000 56.40685 ? 869 HOH A O   1 
HETATM 3288 O O   . HOH E 4 .   ? 0.25831   8.32102   77.71659 1.000 45.27351 ? 870 HOH A O   1 
HETATM 3289 O O   . HOH E 4 .   ? -10.72901 -12.72433 62.49693 1.000 45.94422 ? 871 HOH A O   1 
HETATM 3290 O O   . HOH E 4 .   ? -13.26731 -10.99519 44.19899 1.000 51.54291 ? 872 HOH A O   1 
HETATM 3291 O O   . HOH E 4 .   ? 2.93874   6.13581   74.69347 1.000 65.13886 ? 873 HOH A O   1 
HETATM 3292 O O   . HOH E 4 .   ? -4.50460  -13.25346 63.28394 1.000 56.19223 ? 874 HOH A O   1 
HETATM 3293 O O   . HOH E 4 .   ? 1.69565   8.93634   79.41775 1.000 55.39477 ? 875 HOH A O   1 
HETATM 3294 O O   . HOH E 4 .   ? -19.73570 10.02401  16.37490 1.000 53.48629 ? 876 HOH A O   1 
# 
loop_
_atom_site_anisotrop.id 
_atom_site_anisotrop.type_symbol 
_atom_site_anisotrop.pdbx_label_atom_id 
_atom_site_anisotrop.pdbx_label_alt_id 
_atom_site_anisotrop.pdbx_label_comp_id 
_atom_site_anisotrop.pdbx_label_asym_id 
_atom_site_anisotrop.pdbx_label_seq_id 
_atom_site_anisotrop.pdbx_PDB_ins_code 
_atom_site_anisotrop.U[1][1] 
_atom_site_anisotrop.U[2][2] 
_atom_site_anisotrop.U[3][3] 
_atom_site_anisotrop.U[1][2] 
_atom_site_anisotrop.U[1][3] 
_atom_site_anisotrop.U[2][3] 
_atom_site_anisotrop.pdbx_auth_seq_id 
_atom_site_anisotrop.pdbx_auth_comp_id 
_atom_site_anisotrop.pdbx_auth_asym_id 
_atom_site_anisotrop.pdbx_auth_atom_id 
1    N N   . PRO A 15  ? 0.90166 0.72662 0.77729 0.08858  -0.12371 0.08405  9   PRO A N   
2    C CA  . PRO A 15  ? 0.89159 0.73250 0.77208 0.09347  -0.14223 0.08629  9   PRO A CA  
3    C C   . PRO A 15  ? 0.88361 0.73728 0.76261 0.10388  -0.16025 0.10679  9   PRO A C   
4    O O   . PRO A 15  ? 0.88631 0.72942 0.74209 0.11744  -0.19016 0.12158  9   PRO A O   
5    C CB  . PRO A 15  ? 0.90414 0.73166 0.78177 0.08549  -0.12697 0.07690  9   PRO A CB  
6    C CG  . PRO A 15  ? 0.91030 0.72712 0.77879 0.08277  -0.13177 0.08206  9   PRO A CG  
7    C CD  . PRO A 15  ? 0.90542 0.72645 0.77714 0.08455  -0.13861 0.08698  9   PRO A CD  
8    N N   . GLU A 16  ? 0.87819 0.74688 0.78208 0.11019  -0.14107 0.11643  10  GLU A N   
9    C CA  . GLU A 16  ? 0.86538 0.75000 0.79147 0.12740  -0.12123 0.13197  10  GLU A CA  
10   C C   . GLU A 16  ? 0.85730 0.73300 0.80695 0.13780  -0.11310 0.14191  10  GLU A C   
11   O O   . GLU A 16  ? 0.85529 0.72351 0.81194 0.14497  -0.13137 0.15486  10  GLU A O   
12   C CB  . GLU A 16  ? 0.86833 0.77100 0.79158 0.13584  -0.10414 0.12748  10  GLU A CB  
13   C CG  . GLU A 16  ? 0.86448 0.77872 0.77659 0.15742  -0.09810 0.13509  10  GLU A CG  
14   C CD  . GLU A 16  ? 0.85771 0.78761 0.75930 0.18138  -0.11777 0.13629  10  GLU A CD  
15   O OE1 . GLU A 16  ? 0.86235 0.79058 0.73041 0.17893  -0.14463 0.12388  10  GLU A OE1 
16   O OE2 . GLU A 16  ? 0.83114 0.77851 0.74503 0.20323  -0.12285 0.16607  10  GLU A OE2 
17   N N   . MET A 17  ? 0.84556 0.72954 0.81218 0.14382  -0.09909 0.14063  11  MET A N   
18   C CA  . MET A 17  ? 0.82843 0.72699 0.82032 0.15191  -0.08771 0.13927  11  MET A CA  
19   C C   . MET A 17  ? 0.80970 0.69159 0.80750 0.17026  -0.10434 0.13613  11  MET A C   
20   O O   . MET A 17  ? 0.80348 0.68254 0.81094 0.18784  -0.10658 0.14916  11  MET A O   
21   C CB  . MET A 17  ? 0.83464 0.75323 0.83051 0.14324  -0.06103 0.14461  11  MET A CB  
22   C CG  . MET A 17  ? 0.84334 0.77517 0.84972 0.13332  -0.03454 0.15473  11  MET A CG  
23   S SD  . MET A 17  ? 0.85227 0.79117 0.85808 0.12165  -0.01520 0.16006  11  MET A SD  
24   C CE  . MET A 17  ? 0.85150 0.78223 0.85925 0.11695  -0.01367 0.16453  11  MET A CE  
25   N N   . VAL A 18  ? 0.79984 0.67002 0.80108 0.16718  -0.12450 0.11548  12  VAL A N   
26   C CA  . VAL A 18  ? 0.80125 0.66338 0.80467 0.16004  -0.11796 0.09367  12  VAL A CA  
27   C C   . VAL A 18  ? 0.82331 0.66745 0.82756 0.15801  -0.10011 0.05640  12  VAL A C   
28   O O   . VAL A 18  ? 0.81078 0.66588 0.82377 0.18365  -0.12601 0.05278  12  VAL A O   
29   C CB  . VAL A 18  ? 0.78803 0.66105 0.79111 0.15449  -0.12676 0.10056  12  VAL A CB  
30   C CG1 . VAL A 18  ? 0.78412 0.66010 0.77444 0.15014  -0.13073 0.10368  12  VAL A CG1 
31   C CG2 . VAL A 18  ? 0.77676 0.66201 0.78608 0.14994  -0.13947 0.10068  12  VAL A CG2 
32   N N   . ARG A 19  ? 0.84196 0.67357 0.84926 0.12827  -0.06592 0.02711  13  ARG A N   
33   C CA  . ARG A 19  ? 0.85475 0.67009 0.86331 0.09336  -0.04155 -0.00433 13  ARG A CA  
34   C C   . ARG A 19  ? 0.86331 0.66440 0.86927 0.07133  -0.03340 -0.01154 13  ARG A C   
35   O O   . ARG A 19  ? 0.84762 0.65728 0.86806 0.06171  -0.05217 -0.02101 13  ARG A O   
36   C CB  . ARG A 19  ? 0.86000 0.67709 0.86744 0.08167  -0.03413 -0.01944 13  ARG A CB  
37   C CG  . ARG A 19  ? 0.86480 0.68750 0.87876 0.07178  -0.02489 -0.03168 13  ARG A CG  
38   C CD  . ARG A 19  ? 0.86678 0.69612 0.88968 0.06317  -0.01521 -0.04273 13  ARG A CD  
39   N NE  . ARG A 19  ? 0.87371 0.70340 0.90059 0.05478  -0.00365 -0.05440 13  ARG A NE  
40   C CZ  . ARG A 19  ? 0.88048 0.70945 0.91169 0.04571  -0.00206 -0.06094 13  ARG A CZ  
41   N NH1 . ARG A 19  ? 0.87863 0.71172 0.91270 0.04225  -0.01122 -0.06333 13  ARG A NH1 
42   N NH2 . ARG A 19  ? 0.88565 0.70997 0.91821 0.04313  0.00862  -0.06448 13  ARG A NH2 
43   N N   . GLY A 20  ? 0.88048 0.66298 0.87492 0.05419  -0.00458 -0.01208 14  GLY A N   
44   C CA  . GLY A 20  ? 0.88473 0.65485 0.87309 0.04529  0.01125  -0.01315 14  GLY A CA  
45   C C   . GLY A 20  ? 0.89058 0.64862 0.86785 0.02797  0.01572  -0.01075 14  GLY A C   
46   O O   . GLY A 20  ? 0.90380 0.65202 0.87997 0.01197  0.02649  -0.02108 14  GLY A O   
47   N N   . GLN A 21  ? 0.86630 0.62382 0.83391 0.03028  -0.00351 0.01146  15  GLN A N   
48   C CA  . GLN A 21  ? 0.84277 0.61066 0.79677 0.02049  -0.01637 0.02590  15  GLN A CA  
49   C C   . GLN A 21  ? 0.81458 0.58103 0.74991 0.00519  -0.03239 0.04436  15  GLN A C   
50   O O   . GLN A 21  ? 0.83277 0.58251 0.76210 -0.00664 -0.04082 0.04268  15  GLN A O   
51   C CB  . GLN A 21  ? 0.82898 0.62072 0.79204 0.02397  -0.03096 0.02774  15  GLN A CB  
52   C CG  . GLN A 21  ? 0.82820 0.63408 0.79825 0.01715  -0.01737 0.02983  15  GLN A CG  
53   C CD  . GLN A 21  ? 0.82500 0.64297 0.79688 0.00948  -0.01637 0.03531  15  GLN A CD  
54   O OE1 . GLN A 21  ? 0.82232 0.64749 0.79507 -0.00008 -0.01397 0.04475  15  GLN A OE1 
55   N NE2 . GLN A 21  ? 0.82571 0.64596 0.80048 0.00952  -0.01082 0.03584  15  GLN A NE2 
56   N N   . VAL A 22  ? 0.78125 0.54864 0.69495 0.01077  -0.03919 0.08001  16  VAL A N   
57   C CA  . VAL A 22  ? 0.73623 0.50848 0.62602 0.01320  -0.03745 0.12068  16  VAL A CA  
58   C C   . VAL A 22  ? 0.68309 0.49597 0.58177 0.03631  -0.04465 0.12944  16  VAL A C   
59   O O   . VAL A 22  ? 0.68310 0.49025 0.56704 0.03466  -0.08202 0.12217  16  VAL A O   
60   C CB  . VAL A 22  ? 0.74626 0.49718 0.61282 0.00100  -0.04029 0.14322  16  VAL A CB  
61   C CG1 . VAL A 22  ? 0.75004 0.48983 0.61772 -0.00576 -0.02286 0.14245  16  VAL A CG1 
62   C CG2 . VAL A 22  ? 0.74814 0.49988 0.60937 -0.00626 -0.04554 0.15020  16  VAL A CG2 
63   N N   . PHE A 23  ? 0.61517 0.48579 0.53399 0.05042  -0.02729 0.15049  17  PHE A N   
64   C CA  . PHE A 23  ? 0.57022 0.49417 0.49917 0.06344  0.00012  0.16111  17  PHE A CA  
65   C C   . PHE A 23  ? 0.57305 0.49379 0.45733 0.04052  0.00745  0.18801  17  PHE A C   
66   O O   . PHE A 23  ? 0.61238 0.49780 0.48013 0.02965  0.03184  0.20021  17  PHE A O   
67   C CB  . PHE A 23  ? 0.54119 0.49189 0.49803 0.09862  0.01116  0.13771  17  PHE A CB  
68   C CG  . PHE A 23  ? 0.48677 0.47813 0.47003 0.12788  0.00012  0.12554  17  PHE A CG  
69   C CD1 . PHE A 23  ? 0.47084 0.48051 0.47218 0.12610  0.01820  0.06924  17  PHE A CD1 
70   C CD2 . PHE A 23  ? 0.46674 0.47626 0.47789 0.12541  0.00884  0.12714  17  PHE A CD2 
71   C CE1 . PHE A 23  ? 0.44109 0.47040 0.44057 0.14339  0.00698  0.08765  17  PHE A CE1 
72   C CE2 . PHE A 23  ? 0.44772 0.48147 0.46528 0.12651  0.01834  0.10191  17  PHE A CE2 
73   C CZ  . PHE A 23  ? 0.43077 0.47438 0.45439 0.15429  0.01619  0.08543  17  PHE A CZ  
74   N N   . ASP A 24  ? 0.55972 0.49918 0.39087 0.02367  -0.01289 0.18885  18  ASP A N   
75   C CA  . ASP A 24  ? 0.53692 0.51341 0.31088 -0.01126 -0.02805 0.17716  18  ASP A CA  
76   C C   . ASP A 24  ? 0.51266 0.51903 0.32267 -0.01021 0.01369  0.16996  18  ASP A C   
77   O O   . ASP A 24  ? 0.54331 0.50894 0.33184 -0.04827 0.05866  0.15013  18  ASP A O   
78   C CB  . ASP A 24  ? 0.54454 0.54251 0.28474 -0.05041 -0.05640 0.15167  18  ASP A CB  
79   C CG  . ASP A 24  ? 0.56377 0.56897 0.25894 -0.07518 -0.05082 0.13469  18  ASP A CG  
80   O OD1 . ASP A 24  ? 0.57406 0.57076 0.27939 -0.08991 -0.06171 0.12576  18  ASP A OD1 
81   O OD2 . ASP A 24  ? 0.59159 0.56794 0.25921 -0.09003 0.00099  0.14941  18  ASP A OD2 
82   N N   . VAL A 25  ? 0.47345 0.52374 0.32124 0.00553  -0.00588 0.17172  19  VAL A N   
83   C CA  . VAL A 25  ? 0.44442 0.54148 0.30389 0.01619  -0.02793 0.14937  19  VAL A CA  
84   C C   . VAL A 25  ? 0.51301 0.57297 0.27753 0.00621  -0.06525 0.12471  19  VAL A C   
85   O O   . VAL A 25  ? 0.55796 0.58184 0.23757 0.01405  -0.08147 0.09516  19  VAL A O   
86   C CB  . VAL A 25  ? 0.37973 0.53012 0.28202 0.03687  -0.08332 0.13403  19  VAL A CB  
87   C CG1 . VAL A 25  ? 0.37778 0.54350 0.32343 0.02232  -0.06267 0.11946  19  VAL A CG1 
88   C CG2 . VAL A 25  ? 0.40539 0.52574 0.27802 0.04150  -0.05124 0.12007  19  VAL A CG2 
89   N N   . GLY A 26  ? 0.52206 0.60582 0.35109 -0.00670 -0.05662 0.11596  20  GLY A N   
90   C CA  . GLY A 26  ? 0.47637 0.63316 0.35612 0.00291  -0.08406 0.12958  20  GLY A CA  
91   C C   . GLY A 26  ? 0.45043 0.66451 0.37175 -0.01218 -0.06424 0.13675  20  GLY A C   
92   O O   . GLY A 26  ? 0.45204 0.67416 0.39555 -0.01401 -0.01857 0.18162  20  GLY A O   
93   N N   . PRO A 27  ? 0.38790 0.67911 0.35913 -0.03797 -0.08446 0.10152  21  PRO A N   
94   C CA  . PRO A 27  ? 0.33695 0.67477 0.32464 -0.04499 -0.11024 0.09779  21  PRO A CA  
95   C C   . PRO A 27  ? 0.31459 0.65605 0.31695 -0.07558 -0.11087 0.09725  21  PRO A C   
96   O O   . PRO A 27  ? 0.33355 0.67637 0.32826 -0.07502 -0.09521 0.09470  21  PRO A O   
97   C CB  . PRO A 27  ? 0.35695 0.69034 0.33461 -0.04909 -0.09692 0.05682  21  PRO A CB  
98   C CG  . PRO A 27  ? 0.37249 0.69450 0.35071 -0.03686 -0.09472 0.06830  21  PRO A CG  
99   C CD  . PRO A 27  ? 0.38608 0.68913 0.35120 -0.04135 -0.09897 0.08164  21  PRO A CD  
100  N N   . ARG A 28  ? 0.31035 0.62235 0.29296 -0.10635 -0.12562 0.08612  22  ARG A N   
101  C CA  . ARG A 28  ? 0.34402 0.59245 0.27397 -0.08733 -0.10110 0.10737  22  ARG A CA  
102  C C   . ARG A 28  ? 0.35771 0.59475 0.29210 -0.06107 -0.07197 0.10804  22  ARG A C   
103  O O   . ARG A 28  ? 0.39126 0.60614 0.31931 -0.05068 -0.05016 0.10270  22  ARG A O   
104  C CB  . ARG A 28  ? 0.37639 0.56659 0.29935 -0.10958 -0.05751 0.12386  22  ARG A CB  
105  C CG  . ARG A 28  ? 0.39183 0.54894 0.32040 -0.10745 -0.04772 0.12247  22  ARG A CG  
106  C CD  . ARG A 28  ? 0.40829 0.53713 0.33907 -0.12453 -0.04969 0.10897  22  ARG A CD  
107  N NE  . ARG A 28  ? 0.42245 0.51856 0.34767 -0.13483 -0.05242 0.07237  22  ARG A NE  
108  C CZ  . ARG A 28  ? 0.40260 0.50480 0.38551 -0.11442 -0.03903 0.05364  22  ARG A CZ  
109  N NH1 . ARG A 28  ? 0.37276 0.50469 0.40329 -0.09439 -0.02693 0.04110  22  ARG A NH1 
110  N NH2 . ARG A 28  ? 0.41035 0.49638 0.42899 -0.11936 -0.03036 0.05181  22  ARG A NH2 
111  N N   . TYR A 29  ? 0.35783 0.57914 0.28349 -0.02555 -0.08087 0.09296  23  TYR A N   
112  C CA  . TYR A 29  ? 0.33437 0.55949 0.29154 0.01259  -0.10101 0.11886  23  TYR A CA  
113  C C   . TYR A 29  ? 0.37876 0.56466 0.35810 0.03882  -0.08107 0.14838  23  TYR A C   
114  O O   . TYR A 29  ? 0.40760 0.56360 0.36946 0.03832  -0.06831 0.15765  23  TYR A O   
115  C CB  . TYR A 29  ? 0.31509 0.54519 0.27070 0.02369  -0.09169 0.10791  23  TYR A CB  
116  C CG  . TYR A 29  ? 0.28892 0.51586 0.25633 -0.00174 -0.07362 0.10538  23  TYR A CG  
117  C CD1 . TYR A 29  ? 0.29084 0.50331 0.27316 0.00390  -0.02771 0.09452  23  TYR A CD1 
118  C CD2 . TYR A 29  ? 0.23607 0.50433 0.22932 -0.02009 -0.08427 0.10137  23  TYR A CD2 
119  C CE1 . TYR A 29  ? 0.28488 0.48656 0.27663 -0.01800 -0.03024 0.09608  23  TYR A CE1 
120  C CE2 . TYR A 29  ? 0.25692 0.48932 0.23883 -0.04001 -0.05577 0.12355  23  TYR A CE2 
121  C CZ  . TYR A 29  ? 0.28652 0.48138 0.25353 -0.02563 -0.02554 0.10357  23  TYR A CZ  
122  O OH  . TYR A 29  ? 0.27906 0.47656 0.27193 -0.04123 -0.03301 0.07346  23  TYR A OH  
123  N N   . THR A 30  ? 0.36561 0.56799 0.37920 0.06029  -0.08774 0.15584  24  THR A N   
124  C CA  . THR A 30  ? 0.37065 0.58886 0.41975 0.06439  -0.12990 0.11463  24  THR A CA  
125  C C   . THR A 30  ? 0.41504 0.58033 0.44495 0.07504  -0.11712 0.09916  24  THR A C   
126  O O   . THR A 30  ? 0.42568 0.56758 0.39984 0.08403  -0.11878 0.12144  24  THR A O   
127  C CB  . THR A 30  ? 0.40902 0.60508 0.44584 0.05312  -0.12865 0.09823  24  THR A CB  
128  O OG1 . THR A 30  ? 0.40445 0.60325 0.46057 0.06694  -0.13129 0.11754  24  THR A OG1 
129  C CG2 . THR A 30  ? 0.39758 0.60293 0.43692 0.05261  -0.15370 0.07415  24  THR A CG2 
130  N N   . ASN A 31  ? 0.44279 0.57790 0.47808 0.09196  -0.08719 0.09883  25  ASN A N   
131  C CA  . ASN A 31  ? 0.46485 0.57869 0.48195 0.10008  -0.07056 0.08696  25  ASN A CA  
132  C C   . ASN A 31  ? 0.46645 0.55606 0.46919 0.13585  -0.07541 0.08466  25  ASN A C   
133  O O   . ASN A 31  ? 0.48356 0.54568 0.45029 0.14361  -0.04983 0.09261  25  ASN A O   
134  C CB  . ASN A 31  ? 0.49015 0.59042 0.49138 0.09441  -0.07018 0.09391  25  ASN A CB  
135  C CG  . ASN A 31  ? 0.53193 0.60554 0.51144 0.07389  -0.04752 0.06841  25  ASN A CG  
136  O OD1 . ASN A 31  ? 0.56437 0.61715 0.54422 0.06904  -0.02616 0.05856  25  ASN A OD1 
137  N ND2 . ASN A 31  ? 0.53923 0.60883 0.50641 0.07217  -0.04412 0.06106  25  ASN A ND2 
138  N N   . LEU A 32  ? 0.44213 0.54969 0.47967 0.15013  -0.09276 0.06013  26  LEU A N   
139  C CA  . LEU A 32  ? 0.45021 0.54309 0.49855 0.16511  -0.09035 0.04143  26  LEU A CA  
140  C C   . LEU A 32  ? 0.44759 0.52727 0.50879 0.17811  -0.09391 0.02585  26  LEU A C   
141  O O   . LEU A 32  ? 0.50981 0.52470 0.51791 0.17277  -0.04960 0.03441  26  LEU A O   
142  C CB  . LEU A 32  ? 0.46889 0.55843 0.52815 0.11749  -0.06439 0.00983  26  LEU A CB  
143  C CG  . LEU A 32  ? 0.49907 0.57777 0.54887 0.07533  -0.03180 -0.02819 26  LEU A CG  
144  C CD1 . LEU A 32  ? 0.49908 0.58732 0.55410 0.07971  -0.02700 -0.02713 26  LEU A CD1 
145  C CD2 . LEU A 32  ? 0.51369 0.58533 0.54452 0.06511  -0.03079 -0.03304 26  LEU A CD2 
146  N N   . SER A 33  ? 0.43387 0.52550 0.51071 0.15269  -0.08816 -0.01227 27  SER A N   
147  C CA  . SER A 33  ? 0.44171 0.54522 0.52094 0.14217  -0.11663 -0.01901 27  SER A CA  
148  C C   . SER A 33  ? 0.43798 0.55468 0.54657 0.14619  -0.10570 -0.04323 27  SER A C   
149  O O   . SER A 33  ? 0.42442 0.53577 0.52659 0.17226  -0.13120 -0.03748 27  SER A O   
150  C CB  . SER A 33  ? 0.45561 0.55817 0.55111 0.12993  -0.12033 -0.01800 27  SER A CB  
151  O OG  . SER A 33  ? 0.52238 0.58056 0.57770 0.11025  -0.08107 -0.01689 27  SER A OG  
152  N N   . TYR A 34  ? 0.46092 0.57985 0.57823 0.11818  -0.10258 -0.05870 28  TYR A N   
153  C CA  . TYR A 34  ? 0.51656 0.60709 0.59517 0.08567  -0.07517 -0.08869 28  TYR A CA  
154  C C   . TYR A 34  ? 0.54546 0.61303 0.56814 0.07687  -0.03540 -0.10222 28  TYR A C   
155  O O   . TYR A 34  ? 0.57040 0.61751 0.54575 0.06902  -0.00547 -0.12908 28  TYR A O   
156  C CB  . TYR A 34  ? 0.54338 0.61870 0.63063 0.07008  -0.08886 -0.09967 28  TYR A CB  
157  C CG  . TYR A 34  ? 0.57595 0.63970 0.66659 0.05501  -0.08796 -0.09821 28  TYR A CG  
158  C CD1 . TYR A 34  ? 0.58843 0.64900 0.68115 0.05303  -0.09847 -0.09454 28  TYR A CD1 
159  C CD2 . TYR A 34  ? 0.59352 0.65380 0.67435 0.04646  -0.07982 -0.10969 28  TYR A CD2 
160  C CE1 . TYR A 34  ? 0.59294 0.66327 0.68104 0.05861  -0.10761 -0.09339 28  TYR A CE1 
161  C CE2 . TYR A 34  ? 0.60264 0.66404 0.67961 0.04357  -0.08115 -0.11250 28  TYR A CE2 
162  C CZ  . TYR A 34  ? 0.60382 0.67160 0.67730 0.04871  -0.09892 -0.11010 28  TYR A CZ  
163  O OH  . TYR A 34  ? 0.62377 0.68216 0.67710 0.03912  -0.09692 -0.11899 28  TYR A OH  
164  N N   . ILE A 35  ? 0.55187 0.60507 0.56029 0.08182  -0.02542 -0.10134 29  ILE A N   
165  C CA  . ILE A 35  ? 0.54424 0.60696 0.54816 0.07424  -0.04699 -0.10153 29  ILE A CA  
166  C C   . ILE A 35  ? 0.56736 0.60072 0.58027 0.05202  -0.06009 -0.08987 29  ILE A C   
167  O O   . ILE A 35  ? 0.59980 0.59868 0.59829 0.04431  -0.05514 -0.09125 29  ILE A O   
168  C CB  . ILE A 35  ? 0.53104 0.60374 0.50511 0.08759  -0.04093 -0.10997 29  ILE A CB  
169  C CG1 . ILE A 35  ? 0.51463 0.59214 0.43694 0.09275  -0.02978 -0.10952 29  ILE A CG1 
170  C CG2 . ILE A 35  ? 0.54085 0.61084 0.52703 0.09024  -0.06023 -0.10377 29  ILE A CG2 
171  C CD1 . ILE A 35  ? 0.49873 0.60062 0.40318 0.07278  -0.01618 -0.10647 29  ILE A CD1 
172  N N   . GLY A 36  ? 0.54413 0.58541 0.57336 0.03116  -0.09257 -0.08084 30  GLY A N   
173  C CA  . GLY A 36  ? 0.54348 0.55611 0.56147 0.02194  -0.12578 -0.06998 30  GLY A CA  
174  C C   . GLY A 36  ? 0.55158 0.51954 0.55787 0.01426  -0.14888 -0.05714 30  GLY A C   
175  O O   . GLY A 36  ? 0.56403 0.52795 0.59014 0.00842  -0.14640 -0.05172 30  GLY A O   
176  N N   . GLU A 37  ? 0.55970 0.47933 0.52789 0.00866  -0.15311 -0.04061 31  GLU A N   
177  C CA  . GLU A 37  ? 0.55686 0.45194 0.52760 -0.02058 -0.15284 -0.04324 31  GLU A CA  
178  C C   . GLU A 37  ? 0.54111 0.42128 0.50128 -0.07260 -0.13054 -0.02557 31  GLU A C   
179  O O   . GLU A 37  ? 0.53752 0.40726 0.48258 -0.06909 -0.11524 -0.03117 31  GLU A O   
180  C CB  . GLU A 37  ? 0.60825 0.45536 0.55310 -0.00826 -0.14502 -0.07118 31  GLU A CB  
181  C CG  . GLU A 37  ? 0.65294 0.47201 0.61403 -0.00134 -0.11436 -0.06868 31  GLU A CG  
182  C CD  . GLU A 37  ? 0.67921 0.47744 0.66759 -0.00525 -0.10247 -0.06952 31  GLU A CD  
183  O OE1 . GLU A 37  ? 0.70040 0.46228 0.67888 -0.01385 -0.07546 -0.08650 31  GLU A OE1 
184  O OE2 . GLU A 37  ? 0.67653 0.50116 0.69494 -0.02631 -0.12744 -0.06979 31  GLU A OE2 
185  N N   . GLY A 38  ? 0.53336 0.42124 0.48395 -0.10336 -0.11553 -0.00713 32  GLY A N   
186  C CA  . GLY A 38  ? 0.55376 0.44585 0.46886 -0.14893 -0.10514 -0.00099 32  GLY A CA  
187  C C   . GLY A 38  ? 0.57470 0.46940 0.45812 -0.16530 -0.10282 0.01571  32  GLY A C   
188  O O   . GLY A 38  ? 0.61499 0.45706 0.47518 -0.18064 -0.04383 0.04706  32  GLY A O   
189  N N   . ALA A 39  ? 0.56806 0.50000 0.46902 -0.17019 -0.12561 0.01521  33  ALA A N   
190  C CA  . ALA A 39  ? 0.58177 0.52289 0.51887 -0.16305 -0.10277 0.02991  33  ALA A CA  
191  C C   . ALA A 39  ? 0.60240 0.53449 0.56494 -0.16464 -0.10207 0.02290  33  ALA A C   
192  O O   . ALA A 39  ? 0.57836 0.53712 0.58444 -0.17692 -0.11401 0.00535  33  ALA A O   
193  C CB  . ALA A 39  ? 0.57035 0.52664 0.54428 -0.15351 -0.09395 0.02501  33  ALA A CB  
194  N N   . TYR A 40  ? 0.63450 0.54381 0.56184 -0.15174 -0.09093 0.02917  34  TYR A N   
195  C CA  . TYR A 40  ? 0.61970 0.53876 0.57582 -0.14151 -0.08413 0.03985  34  TYR A CA  
196  C C   . TYR A 40  ? 0.61150 0.50142 0.55832 -0.15481 -0.07914 0.03596  34  TYR A C   
197  O O   . TYR A 40  ? 0.63749 0.48893 0.56430 -0.18758 -0.03360 0.03429  34  TYR A O   
198  C CB  . TYR A 40  ? 0.61846 0.57144 0.60574 -0.10822 -0.08010 0.05095  34  TYR A CB  
199  C CG  . TYR A 40  ? 0.61701 0.59557 0.63356 -0.09308 -0.08354 0.06464  34  TYR A CG  
200  C CD1 . TYR A 40  ? 0.62880 0.61077 0.64839 -0.07457 -0.06955 0.07795  34  TYR A CD1 
201  C CD2 . TYR A 40  ? 0.62392 0.60610 0.65625 -0.08921 -0.07171 0.07024  34  TYR A CD2 
202  C CE1 . TYR A 40  ? 0.63317 0.61971 0.65697 -0.07304 -0.07076 0.07939  34  TYR A CE1 
203  C CE2 . TYR A 40  ? 0.62638 0.61392 0.65372 -0.07627 -0.07656 0.08224  34  TYR A CE2 
204  C CZ  . TYR A 40  ? 0.63798 0.61933 0.65479 -0.06464 -0.06745 0.09108  34  TYR A CZ  
205  O OH  . TYR A 40  ? 0.65445 0.62494 0.66789 -0.06160 -0.03936 0.09809  34  TYR A OH  
206  N N   . GLY A 41  ? 0.57871 0.47531 0.53388 -0.12902 -0.09870 0.02108  35  GLY A N   
207  C CA  . GLY A 41  ? 0.56512 0.46218 0.52819 -0.10823 -0.07423 0.03819  35  GLY A CA  
208  C C   . GLY A 41  ? 0.55183 0.43819 0.49627 -0.09337 -0.06866 0.05141  35  GLY A C   
209  O O   . GLY A 41  ? 0.56829 0.46225 0.48263 -0.08541 -0.08556 0.04064  35  GLY A O   
210  N N   . MET A 42  ? 0.52234 0.40163 0.47612 -0.07987 -0.06951 0.06155  36  MET A N   
211  C CA  . MET A 42  ? 0.52789 0.37690 0.48780 -0.02290 -0.08763 0.08461  36  MET A CA  
212  C C   . MET A 42  ? 0.49085 0.36366 0.43849 -0.03602 -0.07128 0.07961  36  MET A C   
213  O O   . MET A 42  ? 0.47990 0.34412 0.42651 -0.02345 -0.05582 0.13052  36  MET A O   
214  C CB  . MET A 42  ? 0.55012 0.37701 0.51819 0.02325  -0.13079 0.10202  36  MET A CB  
215  C CG  . MET A 42  ? 0.58673 0.36463 0.54747 0.03828  -0.11534 0.08928  36  MET A CG  
216  S SD  . MET A 42  ? 0.61623 0.35004 0.57959 0.06181  -0.10256 0.06781  36  MET A SD  
217  C CE  . MET A 42  ? 0.62905 0.34112 0.58599 0.05667  -0.08756 0.05866  36  MET A CE  
218  N N   . VAL A 43  ? 0.47683 0.36870 0.37725 -0.03462 -0.07982 0.04448  37  VAL A N   
219  C CA  . VAL A 43  ? 0.45606 0.37861 0.34724 0.00444  -0.06564 0.02746  37  VAL A CA  
220  C C   . VAL A 43  ? 0.47279 0.38394 0.36191 0.05031  -0.05370 0.05069  37  VAL A C   
221  O O   . VAL A 43  ? 0.50670 0.40248 0.38193 0.04490  -0.05023 0.02067  37  VAL A O   
222  C CB  . VAL A 43  ? 0.41503 0.38769 0.28584 -0.00428 -0.10258 0.00703  37  VAL A CB  
223  C CG1 . VAL A 43  ? 0.40967 0.42271 0.27014 -0.02762 -0.07698 -0.00683 37  VAL A CG1 
224  C CG2 . VAL A 43  ? 0.41244 0.40195 0.27171 -0.00954 -0.11792 0.00427  37  VAL A CG2 
225  N N   . CYS A 44  ? 0.46397 0.38114 0.33742 0.08148  -0.03016 0.09762  38  CYS A N   
226  C CA  . CYS A 44  ? 0.46574 0.39771 0.35762 0.09279  -0.00237 0.09017  38  CYS A CA  
227  C C   . CYS A 44  ? 0.40248 0.42338 0.36352 0.10063  -0.00329 0.06489  38  CYS A C   
228  O O   . CYS A 44  ? 0.37598 0.42377 0.35486 0.10716  0.00643  0.06593  38  CYS A O   
229  C CB  . CYS A 44  ? 0.52372 0.39299 0.37677 0.12018  -0.02255 0.09884  38  CYS A CB  
230  S SG  . CYS A 44  ? 0.60111 0.42382 0.42575 0.10822  0.01013  0.07657  38  CYS A SG  
231  N N   . SER A 45  ? 0.37358 0.45196 0.35985 0.10745  -0.00478 0.06507  39  SER A N   
232  C CA  . SER A 45  ? 0.33318 0.48519 0.34501 0.10519  -0.02101 0.05663  39  SER A CA  
233  C C   . SER A 45  ? 0.32784 0.50818 0.34022 0.09182  -0.02686 0.04950  39  SER A C   
234  O O   . SER A 45  ? 0.36726 0.51541 0.35450 0.08237  -0.04959 0.03537  39  SER A O   
235  C CB  . SER A 45  ? 0.31752 0.49116 0.35116 0.11978  -0.00329 0.07247  39  SER A CB  
236  O OG  . SER A 45  ? 0.31905 0.51609 0.37742 0.11206  -0.01561 0.07355  39  SER A OG  
237  N N   . ALA A 46  ? 0.27925 0.52858 0.32942 0.06979  -0.02678 0.04719  40  ALA A N   
238  C CA  . ALA A 46  ? 0.26087 0.54110 0.31532 0.04615  -0.02849 0.04787  40  ALA A CA  
239  C C   . ALA A 46  ? 0.24495 0.56511 0.32498 0.05437  -0.05726 0.06126  40  ALA A C   
240  O O   . ALA A 46  ? 0.24197 0.56422 0.32520 0.08508  -0.06166 0.05477  40  ALA A O   
241  C CB  . ALA A 46  ? 0.23915 0.53644 0.30570 0.04233  -0.00307 0.03985  40  ALA A CB  
242  N N   . TYR A 47  ? 0.23124 0.58157 0.34204 0.03334  -0.10456 0.08037  41  TYR A N   
243  C CA  . TYR A 47  ? 0.24379 0.60392 0.36801 0.01619  -0.10815 0.10138  41  TYR A CA  
244  C C   . TYR A 47  ? 0.26660 0.60936 0.38891 0.00671  -0.06569 0.12329  41  TYR A C   
245  O O   . TYR A 47  ? 0.28962 0.61981 0.38051 0.00360  -0.04458 0.13283  41  TYR A O   
246  C CB  . TYR A 47  ? 0.25515 0.62759 0.38861 0.00350  -0.11060 0.10707  41  TYR A CB  
247  C CG  . TYR A 47  ? 0.23284 0.65129 0.40172 -0.02801 -0.10262 0.10119  41  TYR A CG  
248  C CD1 . TYR A 47  ? 0.24989 0.66677 0.41095 -0.04664 -0.06882 0.10096  41  TYR A CD1 
249  C CD2 . TYR A 47  ? 0.25470 0.65967 0.43422 -0.03211 -0.06307 0.08534  41  TYR A CD2 
250  C CE1 . TYR A 47  ? 0.23195 0.67767 0.42728 -0.07637 -0.02789 0.09404  41  TYR A CE1 
251  C CE2 . TYR A 47  ? 0.24540 0.67099 0.44218 -0.03531 -0.05604 0.09257  41  TYR A CE2 
252  C CZ  . TYR A 47  ? 0.24378 0.68296 0.44085 -0.06687 -0.03361 0.09219  41  TYR A CZ  
253  O OH  . TYR A 47  ? 0.26393 0.69432 0.43501 -0.07543 -0.03496 0.09647  41  TYR A OH  
254  N N   . ASP A 48  ? 0.25925 0.60718 0.41348 0.00684  -0.08067 0.13311  42  ASP A N   
255  C CA  . ASP A 48  ? 0.26649 0.60183 0.42669 -0.01918 -0.09246 0.11729  42  ASP A CA  
256  C C   . ASP A 48  ? 0.29666 0.61062 0.47734 -0.04342 -0.09018 0.13782  42  ASP A C   
257  O O   . ASP A 48  ? 0.28710 0.60705 0.47321 -0.05317 -0.11727 0.15005  42  ASP A O   
258  C CB  . ASP A 48  ? 0.27103 0.60132 0.43209 -0.02498 -0.06587 0.09735  42  ASP A CB  
259  C CG  . ASP A 48  ? 0.26104 0.60658 0.42248 -0.02993 -0.06704 0.07726  42  ASP A CG  
260  O OD1 . ASP A 48  ? 0.24268 0.61086 0.45897 -0.04537 -0.05903 0.04276  42  ASP A OD1 
261  O OD2 . ASP A 48  ? 0.32939 0.60506 0.41394 -0.02628 -0.05739 0.09087  42  ASP A OD2 
262  N N   . ASN A 49  ? 0.30726 0.61979 0.46949 -0.07497 -0.11546 0.13826  43  ASN A N   
263  C CA  . ASN A 49  ? 0.35584 0.64100 0.48839 -0.08191 -0.13791 0.13733  43  ASN A CA  
264  C C   . ASN A 49  ? 0.39054 0.64549 0.51221 -0.12064 -0.15882 0.10723  43  ASN A C   
265  O O   . ASN A 49  ? 0.40977 0.65483 0.53269 -0.13915 -0.18647 0.06364  43  ASN A O   
266  C CB  . ASN A 49  ? 0.34598 0.66284 0.48571 -0.06533 -0.15851 0.16257  43  ASN A CB  
267  C CG  . ASN A 49  ? 0.34226 0.67705 0.48574 -0.06704 -0.19277 0.15836  43  ASN A CG  
268  O OD1 . ASN A 49  ? 0.33513 0.70364 0.50365 -0.05474 -0.18948 0.15714  43  ASN A OD1 
269  N ND2 . ASN A 49  ? 0.34649 0.67629 0.49364 -0.07978 -0.19606 0.16293  43  ASN A ND2 
270  N N   . LEU A 50  ? 0.41783 0.64322 0.52788 -0.13075 -0.13917 0.11160  44  LEU A N   
271  C CA  . LEU A 50  ? 0.44741 0.63545 0.55341 -0.15789 -0.11399 0.10146  44  LEU A CA  
272  C C   . LEU A 50  ? 0.45453 0.64416 0.55100 -0.18449 -0.15137 0.09889  44  LEU A C   
273  O O   . LEU A 50  ? 0.46731 0.64903 0.57911 -0.20480 -0.15225 0.10185  44  LEU A O   
274  C CB  . LEU A 50  ? 0.46860 0.62798 0.57309 -0.14338 -0.05208 0.11248  44  LEU A CB  
275  C CG  . LEU A 50  ? 0.50400 0.62137 0.60515 -0.14668 0.02459  0.11784  44  LEU A CG  
276  C CD1 . LEU A 50  ? 0.46553 0.61068 0.60335 -0.15721 0.01022  0.11608  44  LEU A CD1 
277  C CD2 . LEU A 50  ? 0.54785 0.64326 0.63967 -0.11755 0.05602  0.10951  44  LEU A CD2 
278  N N   . ASN A 51  ? 0.49586 0.65519 0.52359 -0.17122 -0.12679 0.10304  45  ASN A N   
279  C CA  . ASN A 51  ? 0.49401 0.65677 0.52254 -0.14932 -0.11822 0.11143  45  ASN A CA  
280  C C   . ASN A 51  ? 0.44508 0.66271 0.51535 -0.14988 -0.11145 0.12049  45  ASN A C   
281  O O   . ASN A 51  ? 0.46071 0.66076 0.51415 -0.14965 -0.06823 0.13275  45  ASN A O   
282  C CB  . ASN A 51  ? 0.50908 0.65716 0.52564 -0.12837 -0.13833 0.10773  45  ASN A CB  
283  C CG  . ASN A 51  ? 0.53714 0.66036 0.54169 -0.09964 -0.14167 0.11704  45  ASN A CG  
284  O OD1 . ASN A 51  ? 0.57304 0.66645 0.58468 -0.07221 -0.13000 0.10972  45  ASN A OD1 
285  N ND2 . ASN A 51  ? 0.53817 0.66158 0.53809 -0.08859 -0.11898 0.13900  45  ASN A ND2 
286  N N   . LYS A 52  ? 0.41142 0.67857 0.52236 -0.14521 -0.10678 0.11756  46  LYS A N   
287  C CA  . LYS A 52  ? 0.33640 0.68890 0.51459 -0.14220 -0.12974 0.10213  46  LYS A CA  
288  C C   . LYS A 52  ? 0.32348 0.68215 0.53391 -0.11525 -0.07926 0.10170  46  LYS A C   
289  O O   . LYS A 52  ? 0.32415 0.69351 0.56176 -0.09970 -0.06856 0.10378  46  LYS A O   
290  C CB  . LYS A 52  ? 0.35584 0.70534 0.51152 -0.15989 -0.14524 0.07154  46  LYS A CB  
291  C CG  . LYS A 52  ? 0.43486 0.72355 0.52119 -0.13795 -0.09848 0.06208  46  LYS A CG  
292  C CD  . LYS A 52  ? 0.47379 0.73388 0.51765 -0.14105 -0.09715 0.04618  46  LYS A CD  
293  C CE  . LYS A 52  ? 0.49661 0.74210 0.51246 -0.15898 -0.11334 0.02156  46  LYS A CE  
294  N NZ  . LYS A 52  ? 0.51749 0.74304 0.51364 -0.17073 -0.10045 0.01626  46  LYS A NZ  
295  N N   . VAL A 53  ? 0.35079 0.66475 0.50534 -0.08145 -0.06316 0.10715  47  VAL A N   
296  C CA  . VAL A 53  ? 0.35879 0.63827 0.47106 -0.06318 -0.04597 0.12427  47  VAL A CA  
297  C C   . VAL A 53  ? 0.29886 0.61087 0.41292 -0.04312 -0.08376 0.11165  47  VAL A C   
298  O O   . VAL A 53  ? 0.28587 0.60995 0.41203 -0.05956 -0.08335 0.10464  47  VAL A O   
299  C CB  . VAL A 53  ? 0.41965 0.64639 0.51039 -0.04710 -0.02072 0.12450  47  VAL A CB  
300  C CG1 . VAL A 53  ? 0.42288 0.64193 0.52443 -0.05204 -0.02138 0.11706  47  VAL A CG1 
301  C CG2 . VAL A 53  ? 0.46640 0.65568 0.52457 -0.04607 0.00223  0.13286  47  VAL A CG2 
302  N N   . ARG A 54  ? 0.26344 0.57610 0.37602 -0.00897 -0.06707 0.09924  48  ARG A N   
303  C CA  . ARG A 54  ? 0.27732 0.54347 0.35561 0.03617  -0.04300 0.10245  48  ARG A CA  
304  C C   . ARG A 54  ? 0.27558 0.51690 0.33230 0.01540  -0.03740 0.10779  48  ARG A C   
305  O O   . ARG A 54  ? 0.27086 0.51003 0.33230 0.00192  -0.02043 0.09639  48  ARG A O   
306  C CB  . ARG A 54  ? 0.29868 0.55070 0.36221 0.09951  -0.05087 0.10716  48  ARG A CB  
307  C CG  . ARG A 54  ? 0.31421 0.55722 0.40327 0.14273  -0.03260 0.08610  48  ARG A CG  
308  C CD  . ARG A 54  ? 0.33986 0.57002 0.42801 0.14495  -0.00580 0.08419  48  ARG A CD  
309  N NE  . ARG A 54  ? 0.34762 0.57761 0.43545 0.16280  0.00068  0.08190  48  ARG A NE  
310  C CZ  . ARG A 54  ? 0.36583 0.58954 0.42767 0.17270  -0.01648 0.07803  48  ARG A CZ  
311  N NH1 . ARG A 54  ? 0.39230 0.59832 0.42521 0.18162  -0.00680 0.07492  48  ARG A NH1 
312  N NH2 . ARG A 54  ? 0.36848 0.58911 0.42407 0.19045  -0.02751 0.07714  48  ARG A NH2 
313  N N   . VAL A 55  ? 0.22641 0.48693 0.30455 0.02441  -0.06882 0.11304  49  VAL A N   
314  C CA  . VAL A 55  ? 0.24969 0.44068 0.27537 0.02037  -0.06661 0.08003  49  VAL A CA  
315  C C   . VAL A 55  ? 0.24288 0.41573 0.26448 0.02220  -0.03106 0.05144  49  VAL A C   
316  O O   . VAL A 55  ? 0.26238 0.41653 0.28239 0.04508  -0.03462 0.05881  49  VAL A O   
317  C CB  . VAL A 55  ? 0.24262 0.41293 0.25082 -0.00236 -0.08067 0.06435  49  VAL A CB  
318  C CG1 . VAL A 55  ? 0.25282 0.40408 0.28938 -0.03350 -0.07123 0.04192  49  VAL A CG1 
319  C CG2 . VAL A 55  ? 0.27808 0.41838 0.27242 -0.01086 -0.04108 0.06432  49  VAL A CG2 
320  N N   . ALA A 56  ? 0.24025 0.39720 0.23367 0.01582  -0.04364 0.02683  50  ALA A N   
321  C CA  . ALA A 56  ? 0.24290 0.37623 0.21277 0.00575  -0.00542 0.03465  50  ALA A CA  
322  C C   . ALA A 56  ? 0.26754 0.35269 0.22716 0.02898  0.00517  0.06142  50  ALA A C   
323  O O   . ALA A 56  ? 0.30225 0.34810 0.23887 0.03071  0.01240  0.08260  50  ALA A O   
324  C CB  . ALA A 56  ? 0.24819 0.38129 0.21908 0.00623  0.01036  0.04928  50  ALA A CB  
325  N N   . ILE A 57  ? 0.24440 0.33300 0.22834 0.03674  -0.00348 0.05646  51  ILE A N   
326  C CA  . ILE A 57  ? 0.28093 0.32594 0.22968 0.02048  -0.01621 0.03376  51  ILE A CA  
327  C C   . ILE A 57  ? 0.29036 0.31635 0.25865 0.01960  -0.02584 0.05490  51  ILE A C   
328  O O   . ILE A 57  ? 0.34841 0.32434 0.27367 0.04755  -0.00741 0.07454  51  ILE A O   
329  C CB  . ILE A 57  ? 0.29236 0.33980 0.21787 0.01339  -0.02374 0.04039  51  ILE A CB  
330  C CG1 . ILE A 57  ? 0.27879 0.34315 0.24673 0.00624  -0.05747 0.03649  51  ILE A CG1 
331  C CG2 . ILE A 57  ? 0.31326 0.35725 0.19698 0.02306  -0.02000 0.03407  51  ILE A CG2 
332  C CD1 . ILE A 57  ? 0.30049 0.36173 0.25513 0.05150  -0.06068 0.05199  51  ILE A CD1 
333  N N   . LYS A 58  ? 0.26166 0.30718 0.26746 -0.00686 -0.03315 0.04899  52  LYS A N   
334  C CA  . LYS A 58  ? 0.30245 0.32072 0.26254 -0.05354 -0.05861 0.06578  52  LYS A CA  
335  C C   . LYS A 58  ? 0.34128 0.31181 0.25251 -0.06042 -0.04066 0.07021  52  LYS A C   
336  O O   . LYS A 58  ? 0.35444 0.31738 0.24775 -0.06555 -0.00790 0.07032  52  LYS A O   
337  C CB  . LYS A 58  ? 0.33410 0.36419 0.29064 -0.08224 -0.06102 0.06695  52  LYS A CB  
338  C CG  . LYS A 58  ? 0.37650 0.37158 0.34529 -0.07077 -0.03704 0.09292  52  LYS A CG  
339  C CD  . LYS A 58  ? 0.35985 0.38895 0.38624 -0.02058 -0.09738 0.09702  52  LYS A CD  
340  C CE  . LYS A 58  ? 0.37722 0.37699 0.39730 0.01470  -0.09366 0.11493  52  LYS A CE  
341  N NZ  . LYS A 58  ? 0.39885 0.39061 0.44398 0.00221  -0.04107 0.08182  52  LYS A NZ  
342  N N   . LYS A 59  ? 0.37633 0.30503 0.28760 -0.06165 -0.05390 0.07811  53  LYS A N   
343  C CA  . LYS A 59  ? 0.40425 0.32181 0.32302 -0.03280 -0.05497 0.08038  53  LYS A CA  
344  C C   . LYS A 59  ? 0.42683 0.35153 0.34350 -0.06636 -0.03273 0.04694  53  LYS A C   
345  O O   . LYS A 59  ? 0.46652 0.36954 0.37635 -0.06466 -0.02423 0.01947  53  LYS A O   
346  C CB  . LYS A 59  ? 0.46247 0.31072 0.36888 -0.02141 0.00332  0.11720  53  LYS A CB  
347  C CG  . LYS A 59  ? 0.47367 0.31181 0.39312 -0.00383 -0.01698 0.16113  53  LYS A CG  
348  C CD  . LYS A 59  ? 0.51272 0.33534 0.43522 0.00872  -0.00254 0.16468  53  LYS A CD  
349  C CE  . LYS A 59  ? 0.54972 0.35868 0.48595 0.01611  0.03836  0.18787  53  LYS A CE  
350  N NZ  . LYS A 59  ? 0.58070 0.39713 0.51268 0.02175  0.06515  0.18992  53  LYS A NZ  
351  N N   . ILE A 60  ? 0.36396 0.34235 0.31184 -0.08575 -0.03233 0.07385  54  ILE A N   
352  C CA  . ILE A 60  ? 0.37977 0.36483 0.33095 -0.12114 -0.01235 0.08218  54  ILE A CA  
353  C C   . ILE A 60  ? 0.41551 0.37274 0.34708 -0.15098 -0.04174 0.09596  54  ILE A C   
354  O O   . ILE A 60  ? 0.42868 0.36325 0.28338 -0.13774 -0.02480 0.08380  54  ILE A O   
355  C CB  . ILE A 60  ? 0.34709 0.36660 0.33096 -0.11317 -0.02760 0.08279  54  ILE A CB  
356  C CG1 . ILE A 60  ? 0.38109 0.36502 0.32309 -0.09588 -0.00409 0.08455  54  ILE A CG1 
357  C CG2 . ILE A 60  ? 0.34381 0.38717 0.37200 -0.12617 -0.02421 0.05615  54  ILE A CG2 
358  C CD1 . ILE A 60  ? 0.41121 0.39055 0.33137 -0.09406 0.02777  0.09313  54  ILE A CD1 
359  N N   . SER A 61  ? 0.45169 0.39266 0.40719 -0.18791 -0.06605 0.10425  55  SER A N   
360  C CA  . SER A 61  ? 0.42693 0.42542 0.44929 -0.20477 -0.10345 0.12922  55  SER A CA  
361  C C   . SER A 61  ? 0.46130 0.44854 0.50417 -0.24159 -0.08988 0.12576  55  SER A C   
362  O O   . SER A 61  ? 0.50666 0.44526 0.54476 -0.23437 -0.07190 0.11179  55  SER A O   
363  C CB  . SER A 61  ? 0.45082 0.44703 0.49044 -0.18291 -0.07160 0.11968  55  SER A CB  
364  O OG  . SER A 61  ? 0.49112 0.46254 0.51113 -0.16589 -0.04995 0.13327  55  SER A OG  
365  N N   . PRO A 62  ? 0.45110 0.48018 0.47929 -0.24883 -0.10891 0.17022  56  PRO A N   
366  C CA  . PRO A 62  ? 0.48674 0.50812 0.48456 -0.25416 -0.09292 0.19818  56  PRO A CA  
367  C C   . PRO A 62  ? 0.49807 0.54988 0.46108 -0.26109 -0.11169 0.22090  56  PRO A C   
368  O O   . PRO A 62  ? 0.53384 0.54843 0.45678 -0.26058 -0.11380 0.22688  56  PRO A O   
369  C CB  . PRO A 62  ? 0.47839 0.48727 0.49473 -0.24032 -0.06041 0.19095  56  PRO A CB  
370  C CG  . PRO A 62  ? 0.48178 0.47702 0.48759 -0.24521 -0.06336 0.17873  56  PRO A CG  
371  C CD  . PRO A 62  ? 0.47670 0.46561 0.47738 -0.24647 -0.08217 0.17267  56  PRO A CD  
372  N N   . PHE A 63  ? 0.49296 0.59677 0.44474 -0.26433 -0.12000 0.23789  57  PHE A N   
373  C CA  . PHE A 63  ? 0.48088 0.65502 0.45893 -0.25660 -0.07953 0.24852  57  PHE A CA  
374  C C   . PHE A 63  ? 0.51532 0.69594 0.53516 -0.25478 -0.04326 0.27373  57  PHE A C   
375  O O   . PHE A 63  ? 0.51757 0.74133 0.55127 -0.22333 -0.01402 0.30272  57  PHE A O   
376  C CB  . PHE A 63  ? 0.43659 0.67780 0.41195 -0.24346 -0.09082 0.23975  57  PHE A CB  
377  C CG  . PHE A 63  ? 0.35093 0.67336 0.36010 -0.22638 -0.06959 0.20171  57  PHE A CG  
378  C CD1 . PHE A 63  ? 0.35068 0.69598 0.35919 -0.21235 -0.04854 0.20496  57  PHE A CD1 
379  C CD2 . PHE A 63  ? 0.31892 0.66173 0.30631 -0.22216 -0.07508 0.16684  57  PHE A CD2 
380  C CE1 . PHE A 63  ? 0.34931 0.69934 0.31751 -0.20451 -0.04740 0.19257  57  PHE A CE1 
381  C CE2 . PHE A 63  ? 0.36076 0.70351 0.31558 -0.22705 -0.03935 0.16793  57  PHE A CE2 
382  C CZ  . PHE A 63  ? 0.34871 0.71232 0.29607 -0.21169 -0.06325 0.18363  57  PHE A CZ  
383  N N   . GLU A 64  ? 0.52625 0.68596 0.57679 -0.28211 -0.05754 0.26035  58  GLU A N   
384  C CA  . GLU A 64  ? 0.52617 0.69209 0.63020 -0.30097 -0.07232 0.24893  58  GLU A CA  
385  C C   . GLU A 64  ? 0.52211 0.70425 0.65315 -0.30840 -0.10603 0.25495  58  GLU A C   
386  O O   . GLU A 64  ? 0.53328 0.72939 0.67640 -0.31749 -0.13110 0.27010  58  GLU A O   
387  C CB  . GLU A 64  ? 0.53489 0.68197 0.63784 -0.30203 -0.05768 0.24050  58  GLU A CB  
388  C CG  . GLU A 64  ? 0.53546 0.67989 0.63313 -0.29643 -0.05539 0.24765  58  GLU A CG  
389  C CD  . GLU A 64  ? 0.54425 0.68176 0.64200 -0.28666 -0.05075 0.24208  58  GLU A CD  
390  O OE1 . GLU A 64  ? 0.55535 0.67838 0.64608 -0.27055 -0.03839 0.23478  58  GLU A OE1 
391  O OE2 . GLU A 64  ? 0.55584 0.68384 0.64480 -0.26800 -0.04725 0.23284  58  GLU A OE2 
392  N N   . HIS A 65  ? 0.54719 0.70706 0.69074 -0.31342 -0.09232 0.26060  59  HIS A N   
393  C CA  . HIS A 65  ? 0.55750 0.70328 0.69970 -0.30699 -0.08990 0.27652  59  HIS A CA  
394  C C   . HIS A 65  ? 0.51134 0.71445 0.69155 -0.29372 -0.10554 0.28124  59  HIS A C   
395  O O   . HIS A 65  ? 0.49784 0.70759 0.67241 -0.29299 -0.11955 0.27337  59  HIS A O   
396  C CB  . HIS A 65  ? 0.60918 0.69207 0.70627 -0.27627 -0.06228 0.27022  59  HIS A CB  
397  C CG  . HIS A 65  ? 0.63622 0.68549 0.72104 -0.25616 -0.04777 0.25834  59  HIS A CG  
398  N ND1 . HIS A 65  ? 0.64593 0.68457 0.72473 -0.25014 -0.03557 0.25362  59  HIS A ND1 
399  C CD2 . HIS A 65  ? 0.64576 0.68716 0.73831 -0.25457 -0.05035 0.24086  59  HIS A CD2 
400  C CE1 . HIS A 65  ? 0.65064 0.68350 0.72679 -0.24460 -0.04893 0.24727  59  HIS A CE1 
401  N NE2 . HIS A 65  ? 0.64898 0.68146 0.73456 -0.25368 -0.04400 0.24748  59  HIS A NE2 
402  N N   . GLN A 66  ? 0.46463 0.72293 0.70401 -0.27751 -0.10699 0.27269  60  GLN A N   
403  C CA  . GLN A 66  ? 0.43077 0.72476 0.69753 -0.26313 -0.11449 0.26248  60  GLN A CA  
404  C C   . GLN A 66  ? 0.45695 0.71727 0.65536 -0.26559 -0.12747 0.25432  60  GLN A C   
405  O O   . GLN A 66  ? 0.47429 0.72773 0.64262 -0.27467 -0.12123 0.25062  60  GLN A O   
406  C CB  . GLN A 66  ? 0.42254 0.73176 0.72789 -0.25142 -0.08372 0.24108  60  GLN A CB  
407  C CG  . GLN A 66  ? 0.44658 0.74665 0.75108 -0.20337 -0.06074 0.22965  60  GLN A CG  
408  C CD  . GLN A 66  ? 0.52975 0.76170 0.77177 -0.17259 -0.01423 0.20244  60  GLN A CD  
409  O OE1 . GLN A 66  ? 0.57893 0.76850 0.77523 -0.14981 0.00332  0.19117  60  GLN A OE1 
410  N NE2 . GLN A 66  ? 0.52437 0.75899 0.77822 -0.17265 -0.00697 0.20065  60  GLN A NE2 
411  N N   . THR A 67  ? 0.49209 0.70679 0.65338 -0.26825 -0.09998 0.23963  61  THR A N   
412  C CA  . THR A 67  ? 0.50435 0.69075 0.64570 -0.28738 -0.10115 0.21013  61  THR A CA  
413  C C   . THR A 67  ? 0.46316 0.66704 0.60177 -0.28742 -0.11665 0.21250  61  THR A C   
414  O O   . THR A 67  ? 0.45837 0.65075 0.58788 -0.28246 -0.09031 0.21377  61  THR A O   
415  C CB  . THR A 67  ? 0.52568 0.69670 0.63089 -0.28622 -0.17116 0.17668  61  THR A CB  
416  O OG1 . THR A 67  ? 0.59894 0.70662 0.64318 -0.25830 -0.15399 0.16876  61  THR A OG1 
417  C CG2 . THR A 67  ? 0.51750 0.69604 0.64935 -0.28839 -0.16639 0.16931  61  THR A CG2 
418  N N   . TYR A 68  ? 0.46811 0.64944 0.56828 -0.27567 -0.11475 0.22400  62  TYR A N   
419  C CA  . TYR A 68  ? 0.45968 0.63093 0.51614 -0.27845 -0.12965 0.20666  62  TYR A CA  
420  C C   . TYR A 68  ? 0.43145 0.64210 0.46425 -0.27206 -0.13307 0.22733  62  TYR A C   
421  O O   . TYR A 68  ? 0.43224 0.62630 0.43511 -0.26835 -0.14119 0.23244  62  TYR A O   
422  C CB  . TYR A 68  ? 0.52505 0.61510 0.53686 -0.25136 -0.10514 0.18334  62  TYR A CB  
423  C CG  . TYR A 68  ? 0.55015 0.60170 0.54937 -0.24420 -0.09659 0.16925  62  TYR A CG  
424  C CD1 . TYR A 68  ? 0.55647 0.59488 0.54538 -0.24392 -0.08465 0.16931  62  TYR A CD1 
425  C CD2 . TYR A 68  ? 0.56177 0.59986 0.56720 -0.22851 -0.09913 0.15432  62  TYR A CD2 
426  C CE1 . TYR A 68  ? 0.56930 0.59508 0.54967 -0.23181 -0.07258 0.15959  62  TYR A CE1 
427  C CE2 . TYR A 68  ? 0.57274 0.60357 0.56868 -0.21380 -0.08942 0.15212  62  TYR A CE2 
428  C CZ  . TYR A 68  ? 0.57862 0.59965 0.55331 -0.21715 -0.08427 0.14182  62  TYR A CZ  
429  O OH  . TYR A 68  ? 0.59820 0.60137 0.55576 -0.20380 -0.06947 0.14190  62  TYR A OH  
430  N N   . CYS A 69  ? 0.41064 0.66729 0.44454 -0.25773 -0.14369 0.24687  63  CYS A N   
431  C CA  . CYS A 69  ? 0.40616 0.67007 0.44104 -0.24056 -0.09634 0.25176  63  CYS A CA  
432  C C   . CYS A 69  ? 0.34901 0.65786 0.40861 -0.20637 -0.09829 0.25659  63  CYS A C   
433  O O   . CYS A 69  ? 0.33301 0.63548 0.39131 -0.18213 -0.09435 0.25910  63  CYS A O   
434  C CB  . CYS A 69  ? 0.43324 0.69861 0.44900 -0.23300 -0.11559 0.28475  63  CYS A CB  
435  S SG  . CYS A 69  ? 0.47586 0.72285 0.45259 -0.24866 -0.10515 0.28200  63  CYS A SG  
436  N N   . GLN A 70  ? 0.33738 0.64935 0.39106 -0.21001 -0.11286 0.20582  64  GLN A N   
437  C CA  . GLN A 70  ? 0.34648 0.63141 0.40371 -0.17780 -0.10270 0.18840  64  GLN A CA  
438  C C   . GLN A 70  ? 0.35483 0.60703 0.34100 -0.19593 -0.10330 0.16990  64  GLN A C   
439  O O   . GLN A 70  ? 0.35758 0.61334 0.32852 -0.19202 -0.09447 0.16705  64  GLN A O   
440  C CB  . GLN A 70  ? 0.35918 0.64299 0.46648 -0.14566 -0.10427 0.16092  64  GLN A CB  
441  C CG  . GLN A 70  ? 0.38622 0.66122 0.50598 -0.11931 -0.07741 0.15212  64  GLN A CG  
442  C CD  . GLN A 70  ? 0.39666 0.67899 0.52824 -0.09190 -0.06569 0.15137  64  GLN A CD  
443  O OE1 . GLN A 70  ? 0.40111 0.68291 0.52736 -0.07935 -0.06570 0.14825  64  GLN A OE1 
444  N NE2 . GLN A 70  ? 0.42061 0.68849 0.54069 -0.07853 -0.06157 0.15647  64  GLN A NE2 
445  N N   . ARG A 71  ? 0.36742 0.57532 0.31556 -0.22519 -0.07625 0.14154  65  ARG A N   
446  C CA  . ARG A 71  ? 0.40680 0.54497 0.33518 -0.20316 -0.02106 0.12363  65  ARG A CA  
447  C C   . ARG A 71  ? 0.37570 0.50539 0.30761 -0.20687 -0.04300 0.13172  65  ARG A C   
448  O O   . ARG A 71  ? 0.41660 0.48332 0.29368 -0.22453 -0.03057 0.12336  65  ARG A O   
449  C CB  . ARG A 71  ? 0.46803 0.56095 0.35823 -0.16927 0.02604  0.12138  65  ARG A CB  
450  C CG  . ARG A 71  ? 0.50759 0.55892 0.38393 -0.14414 0.01927  0.10531  65  ARG A CG  
451  C CD  A ARG A 71  ? 0.50081 0.56240 0.39999 -0.14410 0.01393  0.09209  65  ARG A CD  
452  C CD  B ARG A 71  ? 0.51324 0.53561 0.40332 -0.15019 0.02791  0.08255  65  ARG A CD  
453  N NE  A ARG A 71  ? 0.48734 0.56590 0.40792 -0.13922 0.01443  0.09957  65  ARG A NE  
454  N NE  B ARG A 71  ? 0.50572 0.50703 0.40742 -0.16181 0.04302  0.09352  65  ARG A NE  
455  C CZ  A ARG A 71  ? 0.46976 0.56809 0.39749 -0.13290 0.01887  0.09806  65  ARG A CZ  
456  C CZ  B ARG A 71  ? 0.49788 0.49683 0.41597 -0.18043 0.02792  0.09011  65  ARG A CZ  
457  N NH1 A ARG A 71  ? 0.47961 0.56291 0.41088 -0.11999 0.03359  0.08864  65  ARG A NH1 
458  N NH1 B ARG A 71  ? 0.49602 0.49505 0.43601 -0.18260 0.02947  0.07427  65  ARG A NH1 
459  N NH2 A ARG A 71  ? 0.41774 0.56933 0.35437 -0.14698 -0.01061 0.10609  65  ARG A NH2 
460  N NH2 B ARG A 71  ? 0.48457 0.48188 0.37274 -0.19214 0.03026  0.11503  65  ARG A NH2 
461  N N   . THR A 72  ? 0.35296 0.49153 0.25331 -0.18479 -0.07993 0.12067  66  THR A N   
462  C CA  . THR A 72  ? 0.31751 0.46817 0.26979 -0.15463 -0.04805 0.14028  66  THR A CA  
463  C C   . THR A 72  ? 0.25770 0.46831 0.27087 -0.10942 -0.02429 0.12352  66  THR A C   
464  O O   . THR A 72  ? 0.21309 0.43149 0.26078 -0.07622 -0.02829 0.13502  66  THR A O   
465  C CB  . THR A 72  ? 0.32683 0.45474 0.29139 -0.16283 -0.04137 0.15484  66  THR A CB  
466  O OG1 . THR A 72  ? 0.35969 0.46286 0.31472 -0.18120 -0.04900 0.15876  66  THR A OG1 
467  C CG2 . THR A 72  ? 0.29295 0.43875 0.30911 -0.18028 -0.05269 0.12799  66  THR A CG2 
468  N N   . LEU A 73  ? 0.25249 0.49945 0.26026 -0.08518 -0.03111 0.11125  67  LEU A N   
469  C CA  . LEU A 73  ? 0.26700 0.52132 0.29288 -0.04746 0.03752  0.15862  67  LEU A CA  
470  C C   . LEU A 73  ? 0.27072 0.50125 0.28758 -0.01337 0.01720  0.17183  67  LEU A C   
471  O O   . LEU A 73  ? 0.22040 0.47045 0.31736 0.01303  0.03323  0.17057  67  LEU A O   
472  C CB  . LEU A 73  ? 0.22502 0.55939 0.32603 -0.02923 0.04786  0.15443  67  LEU A CB  
473  C CG  . LEU A 73  ? 0.20144 0.57705 0.34768 0.00183  0.03615  0.15012  67  LEU A CG  
474  C CD1 . LEU A 73  ? 0.23909 0.56756 0.33112 0.01405  0.04232  0.16849  67  LEU A CD1 
475  C CD2 . LEU A 73  ? 0.20163 0.60629 0.39057 0.00323  0.03610  0.13048  67  LEU A CD2 
476  N N   . ARG A 74  ? 0.30854 0.50716 0.27949 -0.03434 -0.01242 0.16272  68  ARG A N   
477  C CA  . ARG A 74  ? 0.32459 0.50205 0.27455 -0.03409 -0.04594 0.12443  68  ARG A CA  
478  C C   . ARG A 74  ? 0.29043 0.45132 0.27031 -0.02012 -0.03858 0.12921  68  ARG A C   
479  O O   . ARG A 74  ? 0.26890 0.44189 0.30647 -0.00525 -0.04531 0.13959  68  ARG A O   
480  C CB  . ARG A 74  ? 0.38474 0.55391 0.33416 -0.01437 -0.04004 0.10789  68  ARG A CB  
481  C CG  . ARG A 74  ? 0.41151 0.58247 0.35761 -0.02814 -0.06771 0.06849  68  ARG A CG  
482  C CD  . ARG A 74  ? 0.46438 0.60264 0.36030 -0.02446 -0.07472 0.07165  68  ARG A CD  
483  N NE  . ARG A 74  ? 0.49073 0.61810 0.36241 -0.02658 -0.08303 0.06477  68  ARG A NE  
484  C CZ  . ARG A 74  ? 0.53408 0.62294 0.34403 -0.00968 -0.06653 0.06589  68  ARG A CZ  
485  N NH1 . ARG A 74  ? 0.57238 0.62696 0.34764 -0.00616 -0.04707 0.07292  68  ARG A NH1 
486  N NH2 . ARG A 74  ? 0.54161 0.62464 0.32908 -0.00923 -0.07390 0.06085  68  ARG A NH2 
487  N N   . GLU A 75  ? 0.28226 0.40132 0.20107 -0.05183 -0.04072 0.09160  69  GLU A N   
488  C CA  . GLU A 75  ? 0.28036 0.36611 0.21112 -0.01441 -0.01398 0.07306  69  GLU A CA  
489  C C   . GLU A 75  ? 0.25264 0.33981 0.18189 -0.00595 -0.00337 0.06107  69  GLU A C   
490  O O   . GLU A 75  ? 0.27596 0.33924 0.18606 0.00334  0.01965  0.05231  69  GLU A O   
491  C CB  . GLU A 75  ? 0.32045 0.34587 0.25771 0.00410  0.01148  0.08283  69  GLU A CB  
492  C CG  . GLU A 75  ? 0.36771 0.33752 0.24617 0.00151  0.03364  0.09849  69  GLU A CG  
493  C CD  . GLU A 75  ? 0.45294 0.35594 0.28057 -0.03029 0.07777  0.09088  69  GLU A CD  
494  O OE1 . GLU A 75  ? 0.50622 0.36362 0.31232 -0.04805 0.06345  0.09362  69  GLU A OE1 
495  O OE2 . GLU A 75  ? 0.40421 0.36077 0.28351 -0.03868 0.08069  0.09895  69  GLU A OE2 
496  N N   . ILE A 76  ? 0.25277 0.34062 0.16959 -0.04368 -0.02649 0.06713  70  ILE A N   
497  C CA  . ILE A 76  ? 0.26669 0.33299 0.16681 -0.04214 -0.04375 0.06648  70  ILE A CA  
498  C C   . ILE A 76  ? 0.28941 0.34207 0.16457 -0.00730 -0.04231 0.06360  70  ILE A C   
499  O O   . ILE A 76  ? 0.32345 0.35507 0.21172 0.01074  -0.04470 0.02399  70  ILE A O   
500  C CB  . ILE A 76  ? 0.26715 0.33766 0.18002 -0.04961 -0.06858 0.08827  70  ILE A CB  
501  C CG1 . ILE A 76  ? 0.28596 0.31379 0.20497 -0.05480 -0.02124 0.13994  70  ILE A CG1 
502  C CG2 . ILE A 76  ? 0.32535 0.37027 0.16993 -0.05887 -0.06309 0.08072  70  ILE A CG2 
503  C CD1 . ILE A 76  ? 0.34014 0.32847 0.21986 -0.07839 -0.01876 0.09521  70  ILE A CD1 
504  N N   . LYS A 77  ? 0.28885 0.36375 0.16092 0.02287  -0.02326 0.08090  71  LYS A N   
505  C CA  . LYS A 77  ? 0.30617 0.37558 0.20011 0.00830  -0.01186 0.09315  71  LYS A CA  
506  C C   . LYS A 77  ? 0.36311 0.36130 0.20304 0.00500  0.00044  0.06008  71  LYS A C   
507  O O   . LYS A 77  ? 0.41146 0.36075 0.22930 -0.00199 -0.00012 0.04860  71  LYS A O   
508  C CB  . LYS A 77  ? 0.27976 0.41412 0.22242 0.03395  0.03821  0.10824  71  LYS A CB  
509  C CG  . LYS A 77  ? 0.34152 0.46669 0.29600 0.02403  0.04489  0.06542  71  LYS A CG  
510  C CD  . LYS A 77  ? 0.38563 0.49927 0.35359 0.03739  0.06174  0.03430  71  LYS A CD  
511  C CE  . LYS A 77  ? 0.45402 0.51391 0.38726 0.04815  0.05845  0.02581  71  LYS A CE  
512  N NZ  . LYS A 77  ? 0.48262 0.51972 0.37257 0.07041  0.06312  0.02762  71  LYS A NZ  
513  N N   . ILE A 78  ? 0.33741 0.33725 0.15442 0.00076  -0.03485 0.04823  72  ILE A N   
514  C CA  . ILE A 78  ? 0.34874 0.32027 0.15607 -0.04361 -0.03004 0.04333  72  ILE A CA  
515  C C   . ILE A 78  ? 0.34821 0.32281 0.18689 -0.02390 -0.01278 0.07145  72  ILE A C   
516  O O   . ILE A 78  ? 0.36066 0.31173 0.19496 -0.06029 -0.03177 0.03552  72  ILE A O   
517  C CB  . ILE A 78  ? 0.31421 0.31320 0.14109 -0.05594 -0.03624 0.03408  72  ILE A CB  
518  C CG1 . ILE A 78  ? 0.34897 0.31584 0.18934 -0.06882 -0.01488 0.02251  72  ILE A CG1 
519  C CG2 . ILE A 78  ? 0.35020 0.31132 0.12998 -0.05656 -0.01953 0.07000  72  ILE A CG2 
520  C CD1 . ILE A 78  ? 0.34363 0.30341 0.19378 -0.07504 -0.01169 0.00166  72  ILE A CD1 
521  N N   . LEU A 79  ? 0.31925 0.33715 0.19100 0.00043  -0.02131 0.09174  73  LEU A N   
522  C CA  . LEU A 79  ? 0.29013 0.33156 0.25233 0.00964  -0.00408 0.12430  73  LEU A CA  
523  C C   . LEU A 79  ? 0.34537 0.34115 0.32494 -0.03396 -0.00610 0.11110  73  LEU A C   
524  O O   . LEU A 79  ? 0.37144 0.33897 0.37042 -0.04624 0.00641  0.09821  73  LEU A O   
525  C CB  . LEU A 79  ? 0.28745 0.33969 0.26295 0.01026  -0.00469 0.11775  73  LEU A CB  
526  C CG  . LEU A 79  ? 0.30247 0.34866 0.23936 0.00701  0.00191  0.09444  73  LEU A CG  
527  C CD1 . LEU A 79  ? 0.28432 0.33436 0.24897 0.03815  -0.03843 0.02823  73  LEU A CD1 
528  C CD2 . LEU A 79  ? 0.31217 0.36400 0.26227 -0.01247 0.05592  0.10415  73  LEU A CD2 
529  N N   . LEU A 80  ? 0.38096 0.33833 0.26399 -0.07504 -0.08055 0.09155  74  LEU A N   
530  C CA  . LEU A 80  ? 0.43407 0.36293 0.31823 -0.10053 -0.06641 0.08627  74  LEU A CA  
531  C C   . LEU A 80  ? 0.42147 0.35463 0.28642 -0.10373 -0.07542 0.05955  74  LEU A C   
532  O O   . LEU A 80  ? 0.49714 0.36624 0.32901 -0.14698 -0.05514 0.07872  74  LEU A O   
533  C CB  . LEU A 80  ? 0.46296 0.38283 0.28796 -0.08818 -0.06448 0.09172  74  LEU A CB  
534  C CG  . LEU A 80  ? 0.47379 0.41512 0.31926 -0.07493 -0.06555 0.12181  74  LEU A CG  
535  C CD1 . LEU A 80  ? 0.51294 0.42874 0.34861 -0.05519 -0.03932 0.14034  74  LEU A CD1 
536  C CD2 . LEU A 80  ? 0.47380 0.41724 0.32255 -0.09194 -0.07492 0.11639  74  LEU A CD2 
537  N N   . ARG A 81  ? 0.36960 0.35593 0.26596 -0.04763 -0.01664 0.01810  75  ARG A N   
538  C CA  A ARG A 81  ? 0.40881 0.36430 0.26717 -0.03531 0.01728  0.00244  75  ARG A CA  
539  C CA  B ARG A 81  ? 0.38564 0.36775 0.25690 -0.03267 -0.01523 -0.01030 75  ARG A CA  
540  C C   . ARG A 81  ? 0.41964 0.34545 0.24013 -0.03936 0.02628  0.00068  75  ARG A C   
541  O O   . ARG A 81  ? 0.56597 0.35642 0.26900 -0.01957 0.09580  -0.04075 75  ARG A O   
542  C CB  A ARG A 81  ? 0.45995 0.39898 0.30871 -0.02068 0.04654  -0.00441 75  ARG A CB  
543  C CB  B ARG A 81  ? 0.42367 0.42139 0.31348 -0.01453 -0.02952 -0.03325 75  ARG A CB  
544  C CG  A ARG A 81  ? 0.52358 0.43291 0.36954 -0.00366 0.06830  0.01027  75  ARG A CG  
545  C CG  B ARG A 81  ? 0.50589 0.47513 0.43519 0.00160  -0.02331 -0.01063 75  ARG A CG  
546  C CD  A ARG A 81  ? 0.57053 0.46155 0.41678 0.00411  0.07226  0.01443  75  ARG A CD  
547  C CD  B ARG A 81  ? 0.56107 0.49513 0.50301 0.00133  -0.03310 0.00120  75  ARG A CD  
548  N NE  A ARG A 81  ? 0.61297 0.48391 0.45533 0.00860  0.07732  0.01623  75  ARG A NE  
549  N NE  B ARG A 81  ? 0.61867 0.51377 0.53446 0.00118  -0.05679 -0.01509 75  ARG A NE  
550  C CZ  A ARG A 81  ? 0.63720 0.49600 0.47173 0.01013  0.06042  0.01714  75  ARG A CZ  
551  C CZ  B ARG A 81  ? 0.65192 0.51060 0.53624 -0.00437 -0.05841 -0.02434 75  ARG A CZ  
552  N NH1 A ARG A 81  ? 0.63808 0.50115 0.48564 0.01481  0.06046  0.00619  75  ARG A NH1 
553  N NH1 B ARG A 81  ? 0.67117 0.51387 0.54779 -0.01780 -0.03716 -0.02831 75  ARG A NH1 
554  N NH2 A ARG A 81  ? 0.65601 0.50311 0.46813 0.00286  0.06096  0.02358  75  ARG A NH2 
555  N NH2 B ARG A 81  ? 0.66735 0.51210 0.52652 -0.00068 -0.05569 -0.04243 75  ARG A NH2 
556  N N   . PHE A 82  ? 0.33506 0.29924 0.19385 -0.03805 -0.01164 0.01160  76  PHE A N   
557  C CA  . PHE A 82  ? 0.30245 0.26893 0.18650 -0.05512 0.00312  0.00703  76  PHE A CA  
558  C C   . PHE A 82  ? 0.29123 0.26194 0.19506 -0.02863 0.00671  0.01923  76  PHE A C   
559  O O   . PHE A 82  ? 0.35457 0.30887 0.20099 -0.02713 -0.00577 0.04582  76  PHE A O   
560  C CB  . PHE A 82  ? 0.28655 0.25609 0.19476 -0.05594 -0.00373 -0.02226 76  PHE A CB  
561  C CG  . PHE A 82  ? 0.28286 0.26584 0.20819 -0.06823 -0.01572 -0.00130 76  PHE A CG  
562  C CD1 . PHE A 82  ? 0.29091 0.27170 0.21083 -0.06571 0.00422  0.02487  76  PHE A CD1 
563  C CD2 . PHE A 82  ? 0.28542 0.26350 0.19439 -0.08191 0.01621  -0.00034 76  PHE A CD2 
564  C CE1 . PHE A 82  ? 0.31091 0.25029 0.18528 -0.07789 -0.00159 0.00944  76  PHE A CE1 
565  C CE2 . PHE A 82  ? 0.33297 0.27540 0.18666 -0.06937 0.02913  0.01825  76  PHE A CE2 
566  C CZ  . PHE A 82  ? 0.32707 0.26914 0.18616 -0.06608 0.04773  0.01982  76  PHE A CZ  
567  N N   . ARG A 83  ? 0.26277 0.26647 0.19849 -0.06432 0.00939  0.01764  77  ARG A N   
568  C CA  . ARG A 83  ? 0.28512 0.27649 0.18500 -0.06623 -0.01975 0.00154  77  ARG A CA  
569  C C   . ARG A 83  ? 0.30595 0.25676 0.16883 -0.05323 -0.01543 0.00721  77  ARG A C   
570  O O   . ARG A 83  ? 0.32329 0.24264 0.19126 -0.04243 -0.00117 0.01291  77  ARG A O   
571  C CB  A ARG A 83  ? 0.33716 0.29922 0.23631 -0.08278 0.00411  -0.01743 77  ARG A CB  
572  C CB  B ARG A 83  ? 0.34763 0.31677 0.19857 -0.05278 -0.02096 -0.00041 77  ARG A CB  
573  C CG  A ARG A 83  ? 0.38004 0.31778 0.26252 -0.09155 0.00116  -0.04700 77  ARG A CG  
574  C CG  B ARG A 83  ? 0.39601 0.35241 0.18732 -0.03742 -0.04792 -0.01648 77  ARG A CG  
575  C CD  A ARG A 83  ? 0.45102 0.34359 0.31802 -0.08595 0.01715  -0.04323 77  ARG A CD  
576  C CD  B ARG A 83  ? 0.45627 0.39394 0.22435 -0.00543 -0.03808 0.00364  77  ARG A CD  
577  N NE  A ARG A 83  ? 0.52876 0.38782 0.38472 -0.04443 0.04854  -0.03957 77  ARG A NE  
578  N NE  B ARG A 83  ? 0.50272 0.42278 0.20664 0.02044  -0.02575 0.01454  77  ARG A NE  
579  C CZ  A ARG A 83  ? 0.56132 0.40478 0.42673 -0.02631 0.04577  -0.03545 77  ARG A CZ  
580  C CZ  B ARG A 83  ? 0.54196 0.44786 0.23304 0.03942  -0.01280 0.00774  77  ARG A CZ  
581  N NH1 A ARG A 83  ? 0.56523 0.41407 0.44492 -0.02398 0.03577  -0.03678 77  ARG A NH1 
582  N NH1 B ARG A 83  ? 0.54326 0.44159 0.23991 0.04712  -0.00895 0.00156  77  ARG A NH1 
583  N NH2 A ARG A 83  ? 0.57453 0.40863 0.45761 -0.02600 0.03914  -0.04307 77  ARG A NH2 
584  N NH2 B ARG A 83  ? 0.57820 0.47486 0.27485 0.06126  -0.00186 -0.00284 77  ARG A NH2 
585  N N   . HIS A 84  ? 0.26331 0.25441 0.17759 -0.05595 -0.02307 -0.00392 78  HIS A N   
586  C CA  . HIS A 84  ? 0.27781 0.24344 0.19186 -0.03814 -0.00384 -0.00101 78  HIS A CA  
587  C C   . HIS A 84  ? 0.24010 0.23929 0.22239 -0.02456 -0.01612 0.02941  78  HIS A C   
588  O O   . HIS A 84  ? 0.23267 0.20826 0.22888 -0.01153 -0.02549 0.02799  78  HIS A O   
589  C CB  . HIS A 84  ? 0.23875 0.22097 0.16825 -0.05537 -0.03605 0.00741  78  HIS A CB  
590  C CG  . HIS A 84  ? 0.21059 0.20609 0.17456 -0.02251 0.00303  0.01205  78  HIS A CG  
591  N ND1 . HIS A 84  ? 0.21391 0.21988 0.19130 -0.02428 0.00369  0.02795  78  HIS A ND1 
592  C CD2 . HIS A 84  ? 0.17682 0.20916 0.19530 -0.01173 0.02201  0.02435  78  HIS A CD2 
593  C CE1 . HIS A 84  ? 0.17839 0.20549 0.19463 -0.01282 0.00211  0.04448  78  HIS A CE1 
594  N NE2 . HIS A 84  ? 0.18682 0.18849 0.19031 0.01497  0.03995  0.03481  78  HIS A NE2 
595  N N   . GLU A 85  ? 0.20377 0.24151 0.21334 -0.04902 -0.01124 0.01352  79  GLU A N   
596  C CA  . GLU A 85  ? 0.16881 0.24893 0.23476 -0.07653 -0.01931 0.03020  79  GLU A CA  
597  C C   . GLU A 85  ? 0.17695 0.22316 0.22789 -0.05472 -0.02679 0.02141  79  GLU A C   
598  O O   . GLU A 85  ? 0.20860 0.23699 0.25914 -0.03193 -0.04005 0.02920  79  GLU A O   
599  C CB  . GLU A 85  ? 0.22091 0.26814 0.23887 -0.12633 -0.02132 0.06188  79  GLU A CB  
600  C CG  . GLU A 85  ? 0.21113 0.32798 0.28895 -0.13672 -0.04892 0.08591  79  GLU A CG  
601  C CD  . GLU A 85  ? 0.25754 0.38637 0.34263 -0.14909 -0.04129 0.07870  79  GLU A CD  
602  O OE1 . GLU A 85  ? 0.26983 0.41222 0.38382 -0.14068 -0.08981 0.08571  79  GLU A OE1 
603  O OE2 . GLU A 85  ? 0.31955 0.42233 0.37586 -0.13983 0.01024  0.07542  79  GLU A OE2 
604  N N   . ASN A 86  ? 0.13335 0.20719 0.19104 -0.04692 -0.01503 0.01874  80  ASN A N   
605  C CA  . ASN A 86  ? 0.15058 0.19673 0.15603 -0.05857 -0.02221 0.02029  80  ASN A CA  
606  C C   . ASN A 86  ? 0.16822 0.21682 0.17679 -0.02426 -0.00361 0.01431  80  ASN A C   
607  O O   . ASN A 86  ? 0.14718 0.22860 0.17574 -0.00632 -0.00887 0.02672  80  ASN A O   
608  C CB  . ASN A 86  ? 0.17690 0.20391 0.18297 -0.04183 -0.01443 0.03211  80  ASN A CB  
609  C CG  . ASN A 86  ? 0.15684 0.18738 0.20976 -0.01131 0.01320  0.04425  80  ASN A CG  
610  O OD1 . ASN A 86  ? 0.19182 0.17240 0.23351 -0.03203 0.02020  0.04703  80  ASN A OD1 
611  N ND2 . ASN A 86  ? 0.17155 0.20389 0.18870 -0.00830 0.03835  0.02163  80  ASN A ND2 
612  N N   . ILE A 87  ? 0.17431 0.21411 0.16901 -0.00371 -0.00860 0.03704  81  ILE A N   
613  C CA  . ILE A 87  ? 0.19996 0.19726 0.18007 -0.00531 0.02717  0.04634  81  ILE A CA  
614  C C   . ILE A 87  ? 0.20738 0.19667 0.21123 -0.02018 -0.01749 0.03841  81  ILE A C   
615  O O   . ILE A 87  ? 0.20851 0.19824 0.22564 -0.04579 -0.03546 0.04462  81  ILE A O   
616  C CB  . ILE A 87  ? 0.17945 0.20364 0.16646 0.01361  0.00590  0.06481  81  ILE A CB  
617  C CG1 . ILE A 87  ? 0.17207 0.20208 0.17798 0.02414  -0.04969 0.02680  81  ILE A CG1 
618  C CG2 . ILE A 87  ? 0.21324 0.22371 0.18433 -0.03505 0.04712  0.06536  81  ILE A CG2 
619  C CD1 . ILE A 87  ? 0.19431 0.21307 0.23466 0.01961  0.00747  0.02556  81  ILE A CD1 
620  N N   . ILE A 88  ? 0.20198 0.20326 0.20005 0.03496  -0.02859 0.02932  82  ILE A N   
621  C CA  . ILE A 88  ? 0.22910 0.24611 0.20503 0.02767  0.00023  0.05539  82  ILE A CA  
622  C C   . ILE A 88  ? 0.25281 0.29603 0.20130 -0.02291 -0.02225 0.05657  82  ILE A C   
623  O O   . ILE A 88  ? 0.27560 0.37015 0.22714 -0.04556 -0.00432 0.05282  82  ILE A O   
624  C CB  . ILE A 88  ? 0.24147 0.28140 0.25953 0.00213  -0.01000 0.06957  82  ILE A CB  
625  C CG1 . ILE A 88  ? 0.20764 0.28448 0.26541 0.01901  -0.04523 0.03788  82  ILE A CG1 
626  C CG2 . ILE A 88  ? 0.19504 0.29298 0.31307 -0.04183 0.00411  0.10257  82  ILE A CG2 
627  C CD1 . ILE A 88  ? 0.25441 0.29775 0.26809 0.02443  0.03182  0.02773  82  ILE A CD1 
628  N N   . GLY A 89  ? 0.26484 0.25037 0.16354 -0.01701 -0.02813 0.04990  83  GLY A N   
629  C CA  . GLY A 89  ? 0.30523 0.23991 0.13433 -0.03273 0.01455  0.06089  83  GLY A CA  
630  C C   . GLY A 89  ? 0.34650 0.25366 0.17825 -0.02583 -0.01758 0.05722  83  GLY A C   
631  O O   . GLY A 89  ? 0.37280 0.23620 0.20399 -0.02481 -0.02430 0.04780  83  GLY A O   
632  N N   . ILE A 90  ? 0.31609 0.28767 0.14835 -0.05326 -0.04736 0.04244  84  ILE A N   
633  C CA  . ILE A 90  ? 0.26796 0.29909 0.17589 -0.05741 -0.05317 0.07892  84  ILE A CA  
634  C C   . ILE A 90  ? 0.31055 0.30926 0.21128 -0.04212 -0.04475 0.05129  84  ILE A C   
635  O O   . ILE A 90  ? 0.33586 0.31619 0.26005 -0.04018 -0.02286 0.02068  84  ILE A O   
636  C CB  . ILE A 90  ? 0.25982 0.33911 0.17357 -0.05243 -0.05566 0.07129  84  ILE A CB  
637  C CG1 . ILE A 90  ? 0.27141 0.34953 0.18472 -0.05563 -0.04401 0.06279  84  ILE A CG1 
638  C CG2 . ILE A 90  ? 0.27802 0.36345 0.17147 -0.04180 -0.03891 0.04623  84  ILE A CG2 
639  C CD1 . ILE A 90  ? 0.28949 0.35177 0.20155 -0.03301 0.01842  0.08293  84  ILE A CD1 
640  N N   . ASN A 91  ? 0.26566 0.32052 0.21099 -0.07341 -0.06556 0.05972  85  ASN A N   
641  C CA  . ASN A 91  ? 0.29791 0.35047 0.19088 -0.10034 -0.03333 0.04531  85  ASN A CA  
642  C C   . ASN A 91  ? 0.32314 0.34689 0.20948 -0.09648 -0.04034 0.06172  85  ASN A C   
643  O O   . ASN A 91  ? 0.35820 0.35363 0.25351 -0.10642 -0.03206 0.06131  85  ASN A O   
644  C CB  . ASN A 91  ? 0.32546 0.41755 0.23533 -0.08804 0.01750  -0.00289 85  ASN A CB  
645  C CG  . ASN A 91  ? 0.36477 0.47710 0.29055 -0.10650 0.03802  -0.01204 85  ASN A CG  
646  O OD1 . ASN A 91  ? 0.39714 0.52100 0.31618 -0.11169 0.05052  0.01085  85  ASN A OD1 
647  N ND2 . ASN A 91  ? 0.35308 0.47944 0.29613 -0.14925 0.04914  -0.08535 85  ASN A ND2 
648  N N   . ASP A 92  ? 0.31723 0.33995 0.20389 -0.06750 -0.01637 0.08336  86  ASP A N   
649  C CA  . ASP A 92  ? 0.29062 0.34090 0.21448 -0.05040 -0.00228 0.06345  86  ASP A CA  
650  C C   . ASP A 92  ? 0.26640 0.32270 0.21879 -0.03366 -0.01659 0.05446  86  ASP A C   
651  O O   . ASP A 92  ? 0.25001 0.30442 0.19603 -0.02633 -0.02953 0.03382  86  ASP A O   
652  C CB  . ASP A 92  ? 0.27104 0.36417 0.19039 -0.03418 -0.06917 0.03823  86  ASP A CB  
653  C CG  . ASP A 92  ? 0.28019 0.38700 0.25936 -0.01628 -0.06529 0.03670  86  ASP A CG  
654  O OD1 . ASP A 92  ? 0.28384 0.38909 0.26562 -0.02066 -0.03054 0.01567  86  ASP A OD1 
655  O OD2 . ASP A 92  ? 0.30038 0.40111 0.27704 0.00970  -0.06713 0.05990  86  ASP A OD2 
656  N N   . ILE A 93  ? 0.24504 0.31779 0.21848 -0.02424 0.01462  0.05203  87  ILE A N   
657  C CA  . ILE A 93  ? 0.22799 0.32021 0.20544 -0.00372 -0.01231 0.06840  87  ILE A CA  
658  C C   . ILE A 93  ? 0.26497 0.31516 0.21179 0.00411  -0.00105 0.06901  87  ILE A C   
659  O O   . ILE A 93  ? 0.33215 0.30907 0.21191 -0.01818 -0.00393 0.05563  87  ILE A O   
660  C CB  . ILE A 93  ? 0.23858 0.30069 0.20975 0.01611  -0.01982 0.06935  87  ILE A CB  
661  C CG1 . ILE A 93  ? 0.23883 0.29687 0.21851 0.02374  -0.03034 0.06548  87  ILE A CG1 
662  C CG2 . ILE A 93  ? 0.26812 0.29684 0.20444 -0.00466 -0.04069 0.02632  87  ILE A CG2 
663  C CD1 . ILE A 93  ? 0.26656 0.31145 0.26771 0.03151  -0.01166 0.05950  87  ILE A CD1 
664  N N   . ILE A 94  ? 0.29312 0.30408 0.20123 0.00274  0.01194  0.08736  88  ILE A N   
665  C CA  . ILE A 94  ? 0.29358 0.32790 0.21689 -0.01112 -0.01319 0.07151  88  ILE A CA  
666  C C   . ILE A 94  ? 0.29188 0.32220 0.19059 -0.02220 -0.01420 0.07585  88  ILE A C   
667  O O   . ILE A 94  ? 0.27847 0.35858 0.20406 -0.01001 0.00199  0.09785  88  ILE A O   
668  C CB  . ILE A 94  ? 0.26824 0.34824 0.29112 0.00317  0.01795  0.07455  88  ILE A CB  
669  C CG1 . ILE A 94  ? 0.29070 0.36787 0.35629 0.00600  0.03983  0.07355  88  ILE A CG1 
670  C CG2 . ILE A 94  ? 0.27888 0.34044 0.31834 0.00921  0.03236  0.08017  88  ILE A CG2 
671  C CD1 . ILE A 94  ? 0.29056 0.38783 0.37986 0.00163  0.07102  0.07625  88  ILE A CD1 
672  N N   . ARG A 95  ? 0.28562 0.29363 0.17790 -0.01020 -0.01293 0.06060  89  ARG A N   
673  C CA  . ARG A 95  ? 0.29533 0.28302 0.19076 -0.00603 -0.03441 0.05443  89  ARG A CA  
674  C C   . ARG A 95  ? 0.32935 0.28561 0.17982 -0.01975 -0.00667 0.04888  89  ARG A C   
675  O O   . ARG A 95  ? 0.36603 0.28608 0.17660 -0.04082 0.00003  0.03104  89  ARG A O   
676  C CB  . ARG A 95  ? 0.33451 0.26598 0.23134 0.01318  -0.01152 0.05258  89  ARG A CB  
677  C CG  . ARG A 95  ? 0.37193 0.27783 0.27054 0.04198  0.06861  0.05853  89  ARG A CG  
678  C CD  . ARG A 95  ? 0.37585 0.28302 0.24919 0.04884  0.07734  0.05312  89  ARG A CD  
679  N NE  . ARG A 95  ? 0.33312 0.29421 0.20551 0.05608  0.05108  0.01919  89  ARG A NE  
680  C CZ  . ARG A 95  ? 0.34874 0.31181 0.23354 0.05528  0.02957  -0.00021 89  ARG A CZ  
681  N NH1 . ARG A 95  ? 0.33915 0.31345 0.20344 0.05948  0.04291  0.00159  89  ARG A NH1 
682  N NH2 . ARG A 95  ? 0.34868 0.30519 0.25574 0.03596  0.00096  0.00957  89  ARG A NH2 
683  N N   . ALA A 96  ? 0.33567 0.28377 0.16244 -0.04616 -0.00461 0.04983  90  ALA A N   
684  C CA  . ALA A 96  ? 0.34519 0.28371 0.15688 -0.04999 -0.01503 0.07544  90  ALA A CA  
685  C C   . ALA A 96  ? 0.31719 0.29768 0.19126 -0.04193 -0.03149 0.05813  90  ALA A C   
686  O O   . ALA A 96  ? 0.32716 0.30879 0.20107 -0.01885 -0.06222 0.05426  90  ALA A O   
687  C CB  . ALA A 96  ? 0.34850 0.28562 0.18582 -0.09410 -0.01685 0.07942  90  ALA A CB  
688  N N   . PRO A 97  ? 0.30368 0.29119 0.16828 0.00477  -0.04040 0.03570  91  PRO A N   
689  C CA  . PRO A 97  ? 0.31831 0.30759 0.22994 0.00658  -0.01511 0.01359  91  PRO A CA  
690  C C   . PRO A 97  ? 0.28702 0.32906 0.22291 0.03049  -0.00527 0.01047  91  PRO A C   
691  O O   . PRO A 97  ? 0.27269 0.34318 0.25629 0.03860  0.02939  -0.01372 91  PRO A O   
692  C CB  . PRO A 97  ? 0.32497 0.30343 0.21660 0.03546  -0.03004 0.04980  91  PRO A CB  
693  C CG  . PRO A 97  ? 0.32078 0.28268 0.18675 0.03328  -0.02448 0.06129  91  PRO A CG  
694  C CD  . PRO A 97  ? 0.30519 0.30508 0.16282 0.01720  -0.02691 0.03934  91  PRO A CD  
695  N N   . THR A 98  ? 0.25695 0.35632 0.21371 0.02730  -0.00359 0.02672  92  THR A N   
696  C CA  . THR A 98  ? 0.26472 0.37584 0.20094 0.02167  0.03868  0.04865  92  THR A CA  
697  C C   . THR A 98  ? 0.23135 0.41627 0.24270 0.03486  0.03856  0.09993  92  THR A C   
698  O O   . THR A 98  ? 0.26791 0.41447 0.23309 0.04575  0.04734  0.08315  92  THR A O   
699  C CB  . THR A 98  ? 0.33005 0.34599 0.18600 0.03346  0.00468  0.03604  92  THR A CB  
700  O OG1 . THR A 98  ? 0.34368 0.31830 0.18696 0.02920  0.00431  0.02313  92  THR A OG1 
701  C CG2 . THR A 98  ? 0.36562 0.35301 0.22282 0.03437  0.01477  0.03635  92  THR A CG2 
702  N N   . ILE A 99  ? 0.22266 0.46226 0.28294 0.03852  0.06034  0.13366  93  ILE A N   
703  C CA  . ILE A 99  ? 0.25568 0.50153 0.32168 0.00213  0.03894  0.14496  93  ILE A CA  
704  C C   . ILE A 99  ? 0.29299 0.52711 0.32330 -0.03901 0.01676  0.12430  93  ILE A C   
705  O O   . ILE A 99  ? 0.31043 0.54590 0.30866 -0.06681 -0.01078 0.12577  93  ILE A O   
706  C CB  A ILE A 99  ? 0.27232 0.51125 0.34229 -0.00776 0.05667  0.13876  93  ILE A CB  
707  C CB  B ILE A 99  ? 0.22706 0.51669 0.33415 -0.02694 0.03840  0.14848  93  ILE A CB  
708  C CG1 A ILE A 99  ? 0.28655 0.51341 0.34935 -0.01073 0.06032  0.13624  93  ILE A CG1 
709  C CG1 B ILE A 99  ? 0.25737 0.53154 0.33997 -0.01595 0.05570  0.15691  93  ILE A CG1 
710  C CG2 A ILE A 99  ? 0.29292 0.51578 0.35081 -0.00810 0.07809  0.14303  93  ILE A CG2 
711  C CG2 B ILE A 99  ? 0.20915 0.51125 0.32651 -0.05155 0.03058  0.15319  93  ILE A CG2 
712  C CD1 A ILE A 99  ? 0.26869 0.51186 0.35544 -0.02554 0.04836  0.12534  93  ILE A CD1 
713  C CD1 B ILE A 99  ? 0.30116 0.55031 0.37975 -0.00537 0.06519  0.14695  93  ILE A CD1 
714  N N   . GLU A 100 ? 0.29759 0.51713 0.30723 -0.02961 -0.01181 0.14004  94  GLU A N   
715  C CA  . GLU A 100 ? 0.35400 0.47927 0.30914 -0.06943 0.00982  0.12413  94  GLU A CA  
716  C C   . GLU A 100 ? 0.40236 0.43444 0.29505 -0.09558 0.00506  0.09886  94  GLU A C   
717  O O   . GLU A 100 ? 0.46118 0.43495 0.32962 -0.11929 0.00163  0.09084  94  GLU A O   
718  C CB  . GLU A 100 ? 0.35075 0.49097 0.30640 -0.07324 -0.01354 0.10426  94  GLU A CB  
719  C CG  . GLU A 100 ? 0.35606 0.49836 0.31182 -0.05297 -0.00198 0.09100  94  GLU A CG  
720  C CD  . GLU A 100 ? 0.37130 0.50540 0.30970 -0.03002 -0.01001 0.08376  94  GLU A CD  
721  O OE1 . GLU A 100 ? 0.38457 0.51242 0.31364 0.00208  -0.01408 0.09218  94  GLU A OE1 
722  O OE2 . GLU A 100 ? 0.37828 0.50778 0.30938 -0.01411 -0.01708 0.08156  94  GLU A OE2 
723  N N   . GLN A 101 ? 0.35849 0.38759 0.24950 -0.07737 -0.04550 0.10970  95  GLN A N   
724  C CA  . GLN A 101 ? 0.35107 0.33908 0.19621 -0.07089 -0.04788 0.08741  95  GLN A CA  
725  C C   . GLN A 101 ? 0.38842 0.33902 0.22085 -0.06394 -0.02930 0.06484  95  GLN A C   
726  O O   . GLN A 101 ? 0.40946 0.30815 0.23737 0.00140  -0.02820 0.03364  95  GLN A O   
727  C CB  . GLN A 101 ? 0.33916 0.31371 0.18129 -0.03278 -0.07710 0.05105  95  GLN A CB  
728  C CG  . GLN A 101 ? 0.30860 0.29983 0.19834 -0.01107 -0.12763 0.05118  95  GLN A CG  
729  C CD  . GLN A 101 ? 0.30272 0.29297 0.23916 0.00767  -0.11355 0.03969  95  GLN A CD  
730  O OE1 . GLN A 101 ? 0.34345 0.32303 0.28862 0.01858  -0.04192 0.03150  95  GLN A OE1 
731  N NE2 . GLN A 101 ? 0.30817 0.27612 0.25396 -0.00290 -0.07642 0.04810  95  GLN A NE2 
732  N N   . MET A 102 ? 0.38750 0.34651 0.17470 -0.08324 -0.03774 0.09375  96  MET A N   
733  C CA  . MET A 102 ? 0.40735 0.36377 0.17944 -0.10869 -0.04013 0.09840  96  MET A CA  
734  C C   . MET A 102 ? 0.43626 0.38868 0.22229 -0.14522 -0.08149 0.08810  96  MET A C   
735  O O   . MET A 102 ? 0.41492 0.42677 0.30448 -0.18235 -0.07179 0.04972  96  MET A O   
736  C CB  . MET A 102 ? 0.37524 0.38468 0.18705 -0.06146 -0.03105 0.10610  96  MET A CB  
737  C CG  . MET A 102 ? 0.34702 0.41588 0.21528 -0.02360 -0.03221 0.09285  96  MET A CG  
738  S SD  . MET A 102 ? 0.28774 0.45347 0.25453 -0.04241 -0.02637 0.08320  96  MET A SD  
739  C CE  . MET A 102 ? 0.20914 0.48314 0.25224 -0.02070 0.00883  0.05445  96  MET A CE  
740  N N   . LYS A 103 ? 0.50685 0.39160 0.24634 -0.14290 -0.06744 0.07671  97  LYS A N   
741  C CA  . LYS A 103 ? 0.56054 0.41314 0.25149 -0.13603 -0.04223 0.08583  97  LYS A CA  
742  C C   . LYS A 103 ? 0.53508 0.43460 0.23937 -0.13134 -0.04732 0.07683  97  LYS A C   
743  O O   . LYS A 103 ? 0.54211 0.48025 0.27044 -0.15173 -0.05932 0.05473  97  LYS A O   
744  C CB  . LYS A 103 ? 0.59278 0.40475 0.26092 -0.15511 -0.00813 0.11882  97  LYS A CB  
745  C CG  . LYS A 103 ? 0.61580 0.43089 0.28598 -0.12470 -0.00141 0.10149  97  LYS A CG  
746  C CD  . LYS A 103 ? 0.63090 0.45167 0.32801 -0.10235 0.01146  0.08271  97  LYS A CD  
747  C CE  . LYS A 103 ? 0.64194 0.46487 0.36481 -0.08346 0.02161  0.08181  97  LYS A CE  
748  N NZ  . LYS A 103 ? 0.63874 0.45270 0.38800 -0.09233 0.01539  0.07916  97  LYS A NZ  
749  N N   . ASP A 104 ? 0.50070 0.40607 0.25060 -0.09853 -0.03444 0.09797  98  ASP A N   
750  C CA  . ASP A 104 ? 0.47163 0.38962 0.27710 -0.07524 -0.00226 0.10797  98  ASP A CA  
751  C C   . ASP A 104 ? 0.40745 0.35296 0.23777 -0.10424 -0.01745 0.09108  98  ASP A C   
752  O O   . ASP A 104 ? 0.42568 0.35774 0.24162 -0.12148 -0.02054 0.08677  98  ASP A O   
753  C CB  . ASP A 104 ? 0.47084 0.39447 0.34443 -0.06324 0.00470  0.12775  98  ASP A CB  
754  C CG  . ASP A 104 ? 0.47646 0.42333 0.40256 -0.08045 0.01803  0.12667  98  ASP A CG  
755  O OD1 . ASP A 104 ? 0.49909 0.43456 0.44444 -0.09369 0.02838  0.10388  98  ASP A OD1 
756  O OD2 . ASP A 104 ? 0.47432 0.42882 0.42039 -0.06161 0.01148  0.15999  98  ASP A OD2 
757  N N   . VAL A 105 ? 0.39449 0.34016 0.25953 -0.08210 0.00734  0.07199  99  VAL A N   
758  C CA  . VAL A 105 ? 0.36963 0.32151 0.25959 -0.07588 0.01277  0.05805  99  VAL A CA  
759  C C   . VAL A 105 ? 0.36197 0.32616 0.27744 -0.07565 0.00781  0.05441  99  VAL A C   
760  O O   . VAL A 105 ? 0.39629 0.33736 0.27070 -0.10700 -0.01030 0.03207  99  VAL A O   
761  C CB  . VAL A 105 ? 0.37946 0.32893 0.33619 -0.05884 0.03810  0.05363  99  VAL A CB  
762  C CG1 . VAL A 105 ? 0.38823 0.35199 0.36923 -0.03301 0.01052  0.07678  99  VAL A CG1 
763  C CG2 . VAL A 105 ? 0.42271 0.33498 0.36425 -0.05333 0.08356  0.06385  99  VAL A CG2 
764  N N   . TYR A 106 ? 0.30528 0.30855 0.25185 -0.07168 0.00099  0.06391  100 TYR A N   
765  C CA  . TYR A 106 ? 0.30834 0.29831 0.25316 -0.03349 0.01227  0.04882  100 TYR A CA  
766  C C   . TYR A 106 ? 0.30611 0.29085 0.25672 -0.03671 0.00581  0.05117  100 TYR A C   
767  O O   . TYR A 106 ? 0.31198 0.28530 0.28087 -0.04910 0.00254  0.05726  100 TYR A O   
768  C CB  . TYR A 106 ? 0.30149 0.29404 0.24702 -0.03048 -0.02712 0.02607  100 TYR A CB  
769  C CG  . TYR A 106 ? 0.34767 0.31340 0.27279 -0.03261 -0.00020 0.06491  100 TYR A CG  
770  C CD1 . TYR A 106 ? 0.36433 0.32008 0.28360 -0.03431 0.01405  0.08475  100 TYR A CD1 
771  C CD2 . TYR A 106 ? 0.40091 0.31234 0.29726 -0.03370 0.01035  0.07389  100 TYR A CD2 
772  C CE1 . TYR A 106 ? 0.42991 0.33637 0.32376 -0.01030 0.04560  0.07268  100 TYR A CE1 
773  C CE2 . TYR A 106 ? 0.43921 0.33113 0.31355 -0.01565 0.00040  0.08285  100 TYR A CE2 
774  C CZ  . TYR A 106 ? 0.47292 0.34033 0.35022 -0.02168 0.02118  0.08324  100 TYR A CZ  
775  O OH  . TYR A 106 ? 0.52803 0.33503 0.38225 -0.02533 -0.00395 0.09891  100 TYR A OH  
776  N N   . ILE A 107 ? 0.28471 0.29835 0.20075 -0.05178 0.00424  0.05110  101 ILE A N   
777  C CA  . ILE A 107 ? 0.26560 0.31237 0.22079 -0.00716 -0.00818 0.05858  101 ILE A CA  
778  C C   . ILE A 107 ? 0.24885 0.30461 0.18301 -0.01958 0.00278  0.05317  101 ILE A C   
779  O O   . ILE A 107 ? 0.31296 0.31825 0.17798 -0.05427 0.00547  0.04537  101 ILE A O   
780  C CB  . ILE A 107 ? 0.29613 0.35923 0.28794 0.00217  0.01743  0.05734  101 ILE A CB  
781  C CG1 . ILE A 107 ? 0.35101 0.40129 0.32361 0.02425  0.02619  0.04620  101 ILE A CG1 
782  C CG2 . ILE A 107 ? 0.32277 0.35828 0.29622 0.00676  0.02005  0.05954  101 ILE A CG2 
783  C CD1 . ILE A 107 ? 0.35922 0.40985 0.34108 0.05428  0.02735  0.01882  101 ILE A CD1 
784  N N   . VAL A 108 ? 0.23345 0.31772 0.18429 -0.00790 0.02674  0.05880  102 VAL A N   
785  C CA  . VAL A 108 ? 0.20831 0.32412 0.18429 -0.01952 -0.02338 0.06839  102 VAL A CA  
786  C C   . VAL A 108 ? 0.22305 0.32147 0.17834 -0.03209 -0.03208 0.04955  102 VAL A C   
787  O O   . VAL A 108 ? 0.28432 0.28851 0.19598 -0.05321 0.00380  0.03599  102 VAL A O   
788  C CB  . VAL A 108 ? 0.23164 0.32494 0.18893 -0.00028 -0.00867 0.07373  102 VAL A CB  
789  C CG1 . VAL A 108 ? 0.21420 0.33962 0.21830 0.00169  -0.03983 0.04565  102 VAL A CG1 
790  C CG2 . VAL A 108 ? 0.28133 0.31236 0.19336 -0.00711 0.00037  0.08503  102 VAL A CG2 
791  N N   . GLN A 109 ? 0.23080 0.32631 0.15489 -0.02233 -0.00313 0.06677  103 GLN A N   
792  C CA  . GLN A 109 ? 0.19871 0.33493 0.18831 -0.00435 -0.03883 0.09171  103 GLN A CA  
793  C C   . GLN A 109 ? 0.24110 0.35083 0.22484 -0.02373 -0.02481 0.10253  103 GLN A C   
794  O O   . GLN A 109 ? 0.27968 0.37264 0.23392 -0.02238 -0.04346 0.10878  103 GLN A O   
795  C CB  . GLN A 109 ? 0.15911 0.35727 0.21575 -0.00791 -0.03162 0.09712  103 GLN A CB  
796  C CG  . GLN A 109 ? 0.20826 0.34272 0.25702 -0.00499 -0.04777 0.08616  103 GLN A CG  
797  C CD  . GLN A 109 ? 0.28955 0.31070 0.30855 -0.01559 -0.02179 0.06018  103 GLN A CD  
798  O OE1 . GLN A 109 ? 0.37528 0.27169 0.33569 -0.02016 -0.02672 0.04097  103 GLN A OE1 
799  N NE2 . GLN A 109 ? 0.25015 0.30471 0.30101 0.01626  -0.01761 0.06285  103 GLN A NE2 
800  N N   . ASP A 110 ? 0.23589 0.34786 0.20743 -0.03156 0.01480  0.07380  104 ASP A N   
801  C CA  . ASP A 110 ? 0.26103 0.34331 0.24989 -0.01691 0.02606  0.07642  104 ASP A CA  
802  C C   . ASP A 110 ? 0.23241 0.36381 0.26145 0.01283  0.02196  0.05419  104 ASP A C   
803  O O   . ASP A 110 ? 0.21348 0.35308 0.25002 0.01724  0.00049  0.03137  104 ASP A O   
804  C CB  . ASP A 110 ? 0.32423 0.33337 0.26161 -0.03616 0.02927  0.06816  104 ASP A CB  
805  C CG  . ASP A 110 ? 0.41229 0.33822 0.24094 -0.04298 0.01519  0.04713  104 ASP A CG  
806  O OD1 . ASP A 110 ? 0.43594 0.36488 0.26467 -0.06925 -0.00399 0.00680  104 ASP A OD1 
807  O OD2 . ASP A 110 ? 0.45474 0.30478 0.22446 -0.03785 0.02037  0.07794  104 ASP A OD2 
808  N N   . LEU A 111 ? 0.21858 0.38085 0.29011 0.05229  0.00769  0.07063  105 LEU A N   
809  C CA  . LEU A 111 ? 0.24030 0.40415 0.29358 0.04966  -0.01587 0.06936  105 LEU A CA  
810  C C   . LEU A 111 ? 0.22291 0.37814 0.26224 0.01638  -0.03361 0.07467  105 LEU A C   
811  O O   . LEU A 111 ? 0.27139 0.38408 0.28525 -0.03212 0.01260  0.04123  105 LEU A O   
812  C CB  . LEU A 111 ? 0.24229 0.42487 0.30764 0.05896  -0.05911 0.07358  105 LEU A CB  
813  C CG  . LEU A 111 ? 0.22436 0.43238 0.31113 0.08069  -0.04353 0.07416  105 LEU A CG  
814  C CD1 . LEU A 111 ? 0.27810 0.42860 0.31682 0.07105  -0.03023 0.08679  105 LEU A CD1 
815  C CD2 . LEU A 111 ? 0.23408 0.44206 0.31627 0.08548  -0.03784 0.06853  105 LEU A CD2 
816  N N   . MET A 112 ? 0.21093 0.36447 0.24214 0.00948  -0.05789 0.07946  106 MET A N   
817  C CA  . MET A 112 ? 0.18237 0.34400 0.23349 0.04804  -0.08341 0.06959  106 MET A CA  
818  C C   . MET A 112 ? 0.23504 0.35840 0.27278 0.04224  -0.00517 0.05918  106 MET A C   
819  O O   . MET A 112 ? 0.28512 0.37946 0.29902 0.06472  0.02882  0.05928  106 MET A O   
820  C CB  . MET A 112 ? 0.18228 0.33971 0.25992 0.04070  -0.08564 0.08534  106 MET A CB  
821  C CG  . MET A 112 ? 0.21395 0.33173 0.33273 0.00516  -0.03368 0.06588  106 MET A CG  
822  S SD  . MET A 112 ? 0.22674 0.32586 0.34100 -0.00306 -0.02414 0.03455  106 MET A SD  
823  C CE  . MET A 112 ? 0.22978 0.34623 0.32639 0.02479  0.00201  0.00546  106 MET A CE  
824  N N   . GLU A 113 ? 0.23834 0.34280 0.24903 0.01842  -0.00316 0.03609  107 GLU A N   
825  C CA  . GLU A 113 ? 0.24632 0.32888 0.27529 0.03163  0.03015  0.04046  107 GLU A CA  
826  C C   . GLU A 113 ? 0.24714 0.31360 0.27612 0.05864  -0.00223 0.04304  107 GLU A C   
827  O O   . GLU A 113 ? 0.25538 0.32303 0.27815 0.07543  -0.00583 0.04928  107 GLU A O   
828  C CB  . GLU A 113 ? 0.24413 0.32563 0.27578 0.02690  0.08236  0.03406  107 GLU A CB  
829  C CG  . GLU A 113 ? 0.25485 0.34627 0.32746 0.01956  0.09380  0.02685  107 GLU A CG  
830  C CD  . GLU A 113 ? 0.21218 0.38284 0.36905 0.01890  0.04769  0.02683  107 GLU A CD  
831  O OE1 . GLU A 113 ? 0.17582 0.41351 0.40291 0.06223  0.02042  0.05572  107 GLU A OE1 
832  O OE2 . GLU A 113 ? 0.22512 0.38950 0.38438 -0.00460 0.04047  0.01709  107 GLU A OE2 
833  N N   . THR A 114 ? 0.23041 0.31216 0.26940 0.06084  -0.02785 0.02457  108 THR A N   
834  C CA  . THR A 114 ? 0.19556 0.30513 0.25881 0.08454  -0.05814 -0.00046 108 THR A CA  
835  C C   . THR A 114 ? 0.22597 0.27746 0.27640 0.07290  -0.06022 -0.00604 108 THR A C   
836  O O   . THR A 114 ? 0.23556 0.24386 0.27054 0.05197  -0.03041 -0.03074 108 THR A O   
837  C CB  . THR A 114 ? 0.27278 0.33292 0.29951 0.08991  -0.05068 -0.02275 108 THR A CB  
838  O OG1 . THR A 114 ? 0.31666 0.36354 0.34416 0.11045  -0.03884 -0.05139 108 THR A OG1 
839  C CG2 . THR A 114 ? 0.28389 0.34563 0.26535 0.08898  -0.00372 0.00820  108 THR A CG2 
840  N N   . ASP A 115 ? 0.24357 0.28732 0.31956 0.08052  -0.07541 -0.02213 109 ASP A N   
841  C CA  . ASP A 115 ? 0.23882 0.29198 0.32148 0.08218  -0.06683 -0.02671 109 ASP A CA  
842  C C   . ASP A 115 ? 0.22951 0.28183 0.31776 0.06289  -0.04723 -0.05025 109 ASP A C   
843  O O   . ASP A 115 ? 0.23192 0.27743 0.30974 0.06900  -0.03821 -0.05433 109 ASP A O   
844  C CB  . ASP A 115 ? 0.30556 0.29429 0.33850 0.09199  -0.04984 -0.01829 109 ASP A CB  
845  C CG  . ASP A 115 ? 0.34471 0.30964 0.36011 0.07823  -0.06443 0.00202  109 ASP A CG  
846  O OD1 . ASP A 115 ? 0.33519 0.30817 0.33694 0.07576  -0.09629 -0.00808 109 ASP A OD1 
847  O OD2 . ASP A 115 ? 0.42540 0.31956 0.39875 0.03165  -0.01979 0.02984  109 ASP A OD2 
848  N N   . LEU A 116 ? 0.23579 0.24750 0.28392 0.03727  -0.03738 -0.03050 110 LEU A N   
849  C CA  . LEU A 116 ? 0.23076 0.19178 0.29825 0.03855  -0.00558 0.00140  110 LEU A CA  
850  C C   . LEU A 116 ? 0.22429 0.18934 0.29559 0.01713  -0.01486 -0.00424 110 LEU A C   
851  O O   . LEU A 116 ? 0.23919 0.18772 0.29250 0.01724  0.01586  -0.00446 110 LEU A O   
852  C CB  . LEU A 116 ? 0.19601 0.21226 0.29497 0.05053  -0.01155 0.02911  110 LEU A CB  
853  C CG  . LEU A 116 ? 0.17476 0.25613 0.29565 0.06957  0.02885  0.03695  110 LEU A CG  
854  C CD1 . LEU A 116 ? 0.22112 0.27929 0.28828 0.05421  0.07165  0.03267  110 LEU A CD1 
855  C CD2 . LEU A 116 ? 0.17608 0.25517 0.31084 0.09089  0.02632  0.05256  110 LEU A CD2 
856  N N   . TYR A 117 ? 0.21932 0.16746 0.31562 0.03454  -0.00457 0.02398  111 TYR A N   
857  C CA  . TYR A 117 ? 0.23211 0.18811 0.37077 0.02544  0.04032  0.02229  111 TYR A CA  
858  C C   . TYR A 117 ? 0.22588 0.20545 0.38705 0.05794  0.01462  0.01735  111 TYR A C   
859  O O   . TYR A 117 ? 0.24166 0.21194 0.40385 0.04979  0.04334  0.02090  111 TYR A O   
860  C CB  . TYR A 117 ? 0.25072 0.17845 0.40851 0.02618  0.04499  0.03407  111 TYR A CB  
861  C CG  . TYR A 117 ? 0.28522 0.19726 0.46423 0.03789  0.05499  0.04061  111 TYR A CG  
862  C CD1 . TYR A 117 ? 0.35537 0.19642 0.51016 -0.00642 0.05357  0.01320  111 TYR A CD1 
863  C CD2 . TYR A 117 ? 0.34099 0.20394 0.52023 0.05238  0.07883  0.03541  111 TYR A CD2 
864  C CE1 . TYR A 117 ? 0.38617 0.19506 0.53260 0.00496  0.06321  0.03296  111 TYR A CE1 
865  C CE2 . TYR A 117 ? 0.39511 0.21097 0.55022 0.03286  0.06740  0.04453  111 TYR A CE2 
866  C CZ  . TYR A 117 ? 0.42897 0.20958 0.56342 0.00180  0.08018  0.03672  111 TYR A CZ  
867  O OH  . TYR A 117 ? 0.47447 0.20382 0.58540 0.00402  0.07234  0.04402  111 TYR A OH  
868  N N   . LYS A 118 ? 0.20075 0.24331 0.38394 0.09507  -0.05735 0.02951  112 LYS A N   
869  C CA  A LYS A 118 ? 0.23977 0.27066 0.39686 0.09234  -0.02857 0.01236  112 LYS A CA  
870  C CA  B LYS A 118 ? 0.22936 0.28162 0.38781 0.10707  -0.06377 0.01226  112 LYS A CA  
871  C C   . LYS A 118 ? 0.25884 0.27204 0.39672 0.07256  -0.02178 -0.01576 112 LYS A C   
872  O O   . LYS A 118 ? 0.25685 0.25822 0.44183 0.04314  -0.02205 -0.03753 112 LYS A O   
873  C CB  A LYS A 118 ? 0.28822 0.29799 0.40608 0.07662  0.02214  0.02699  112 LYS A CB  
874  C CB  B LYS A 118 ? 0.26734 0.33281 0.38725 0.10916  -0.06604 0.02404  112 LYS A CB  
875  C CG  A LYS A 118 ? 0.33918 0.31033 0.42336 0.05006  0.08064  0.03689  112 LYS A CG  
876  C CG  B LYS A 118 ? 0.31147 0.36890 0.41005 0.09841  -0.04910 0.03518  112 LYS A CG  
877  C CD  A LYS A 118 ? 0.39273 0.31295 0.42917 0.03501  0.13186  0.03918  112 LYS A CD  
878  C CD  B LYS A 118 ? 0.34859 0.39267 0.41126 0.10955  -0.05115 0.04894  112 LYS A CD  
879  C CE  A LYS A 118 ? 0.39046 0.30924 0.41776 0.01722  0.16900  0.04943  112 LYS A CE  
880  C CE  B LYS A 118 ? 0.39680 0.41244 0.42436 0.09286  -0.04466 0.05740  112 LYS A CE  
881  N NZ  A LYS A 118 ? 0.34490 0.29842 0.40197 -0.00426 0.19584  0.03468  112 LYS A NZ  
882  N NZ  B LYS A 118 ? 0.41628 0.42361 0.42675 0.06920  -0.04665 0.04069  112 LYS A NZ  
883  N N   . LEU A 119 ? 0.25274 0.26646 0.36855 0.03576  -0.02697 -0.04439 113 LEU A N   
884  C CA  . LEU A 119 ? 0.26213 0.27138 0.40937 0.00496  -0.01985 -0.04415 113 LEU A CA  
885  C C   . LEU A 119 ? 0.25453 0.29863 0.39749 -0.02397 0.02721  -0.04020 113 LEU A C   
886  O O   . LEU A 119 ? 0.25717 0.32095 0.42418 -0.05254 0.07347  -0.06373 113 LEU A O   
887  C CB  . LEU A 119 ? 0.30671 0.26429 0.46666 0.00131  -0.02752 -0.06056 113 LEU A CB  
888  C CG  . LEU A 119 ? 0.30295 0.27732 0.53448 0.00754  -0.01357 -0.03681 113 LEU A CG  
889  C CD1 . LEU A 119 ? 0.29193 0.25705 0.55359 0.00789  -0.02853 -0.02635 113 LEU A CD1 
890  C CD2 . LEU A 119 ? 0.27308 0.31168 0.52233 -0.03725 0.01582  -0.07276 113 LEU A CD2 
891  N N   . LEU A 120 ? 0.23657 0.29776 0.34532 -0.04750 -0.01768 -0.02361 114 LEU A N   
892  C CA  . LEU A 120 ? 0.23171 0.30546 0.34172 -0.04928 0.00975  -0.03802 114 LEU A CA  
893  C C   . LEU A 120 ? 0.22959 0.30178 0.34436 -0.02245 -0.00281 -0.02091 114 LEU A C   
894  O O   . LEU A 120 ? 0.30549 0.30636 0.35961 -0.01961 0.04271  -0.01229 114 LEU A O   
895  C CB  . LEU A 120 ? 0.24719 0.31531 0.36520 -0.02380 0.00990  -0.01712 114 LEU A CB  
896  C CG  . LEU A 120 ? 0.24037 0.34290 0.41145 -0.02747 0.01035  -0.01449 114 LEU A CG  
897  C CD1 . LEU A 120 ? 0.19543 0.35131 0.44114 -0.01551 -0.06397 -0.02180 114 LEU A CD1 
898  C CD2 . LEU A 120 ? 0.29940 0.36615 0.43227 -0.03587 0.03686  -0.01952 114 LEU A CD2 
899  N N   . LYS A 121 ? 0.23359 0.32089 0.38151 -0.02281 0.01434  -0.01339 115 LYS A N   
900  C CA  . LYS A 121 ? 0.30757 0.34495 0.40726 -0.02393 0.03592  -0.00582 115 LYS A CA  
901  C C   . LYS A 121 ? 0.28689 0.33293 0.45109 -0.02192 0.01873  -0.00407 115 LYS A C   
902  O O   . LYS A 121 ? 0.29769 0.34549 0.49498 -0.01696 0.03928  -0.02910 115 LYS A O   
903  C CB  . LYS A 121 ? 0.37774 0.38328 0.44382 -0.02590 0.04798  0.03231  115 LYS A CB  
904  C CG  . LYS A 121 ? 0.47264 0.41050 0.44442 0.00329  0.08460  0.05342  115 LYS A CG  
905  C CD  . LYS A 121 ? 0.52299 0.41485 0.47618 0.03055  0.07188  0.08498  115 LYS A CD  
906  C CE  . LYS A 121 ? 0.54976 0.42596 0.48210 0.04671  0.08119  0.10654  115 LYS A CE  
907  N NZ  . LYS A 121 ? 0.57300 0.43246 0.48948 0.05321  0.07267  0.11535  115 LYS A NZ  
908  N N   . THR A 122 ? 0.27711 0.32369 0.44568 -0.01206 0.01350  0.03404  116 THR A N   
909  C CA  . THR A 122 ? 0.27548 0.32387 0.45799 0.01548  -0.01843 0.06893  116 THR A CA  
910  C C   . THR A 122 ? 0.27242 0.31130 0.49247 0.03839  0.03746  0.05115  116 THR A C   
911  O O   . THR A 122 ? 0.33252 0.33653 0.58034 0.03981  0.10466  0.06727  116 THR A O   
912  C CB  . THR A 122 ? 0.35529 0.32663 0.47439 -0.03249 -0.01343 0.08944  116 THR A CB  
913  O OG1 . THR A 122 ? 0.40379 0.33331 0.48579 -0.06740 -0.02411 0.07565  116 THR A OG1 
914  C CG2 . THR A 122 ? 0.35196 0.31766 0.46202 -0.04197 -0.00982 0.12619  116 THR A CG2 
915  N N   . GLN A 123 ? 0.21340 0.27556 0.41398 0.03822  -0.01249 0.01728  117 GLN A N   
916  C CA  . GLN A 123 ? 0.21342 0.29869 0.38171 0.01399  0.00583  -0.00934 117 GLN A CA  
917  C C   . GLN A 123 ? 0.18738 0.30121 0.36488 0.05028  -0.01661 -0.00370 117 GLN A C   
918  O O   . GLN A 123 ? 0.17417 0.32457 0.40524 0.05948  0.01923  -0.02504 117 GLN A O   
919  C CB  . GLN A 123 ? 0.22315 0.31712 0.36243 0.00179  -0.01205 -0.01870 117 GLN A CB  
920  C CG  . GLN A 123 ? 0.22922 0.33278 0.37543 0.00096  -0.00684 -0.00322 117 GLN A CG  
921  C CD  . GLN A 123 ? 0.24408 0.36237 0.38732 0.02136  0.03587  0.03086  117 GLN A CD  
922  O OE1 . GLN A 123 ? 0.23727 0.36355 0.38397 0.04037  0.03586  0.01748  117 GLN A OE1 
923  N NE2 . GLN A 123 ? 0.26752 0.40272 0.42483 0.03280  0.04952  0.06514  117 GLN A NE2 
924  N N   . HIS A 124 ? 0.26127 0.27915 0.35160 0.05713  0.00792  0.02107  118 HIS A N   
925  C CA  . HIS A 124 ? 0.29842 0.28849 0.34877 0.06927  0.00302  0.00618  118 HIS A CA  
926  C C   . HIS A 124 ? 0.26014 0.28909 0.36675 0.09019  -0.00892 -0.00314 118 HIS A C   
927  O O   . HIS A 124 ? 0.24414 0.28888 0.43002 0.12136  0.00900  -0.01223 118 HIS A O   
928  C CB  . HIS A 124 ? 0.34936 0.31593 0.37476 0.04605  -0.00281 -0.00396 118 HIS A CB  
929  C CG  . HIS A 124 ? 0.36309 0.31733 0.41557 0.05083  0.02272  -0.03003 118 HIS A CG  
930  N ND1 . HIS A 124 ? 0.36756 0.31744 0.42439 0.04252  0.01035  -0.05092 118 HIS A ND1 
931  C CD2 . HIS A 124 ? 0.35654 0.32299 0.44123 0.04720  0.04386  -0.04296 118 HIS A CD2 
932  C CE1 . HIS A 124 ? 0.37033 0.32597 0.44260 0.03040  0.01880  -0.04972 118 HIS A CE1 
933  N NE2 . HIS A 124 ? 0.35175 0.32599 0.44855 0.03973  0.01742  -0.03931 118 HIS A NE2 
934  N N   . LEU A 125 ? 0.22733 0.30228 0.34563 0.09932  0.01405  -0.01899 119 LEU A N   
935  C CA  . LEU A 125 ? 0.20661 0.30073 0.34282 0.11760  0.03991  -0.01401 119 LEU A CA  
936  C C   . LEU A 125 ? 0.26826 0.31454 0.35751 0.04877  0.03537  -0.02286 119 LEU A C   
937  O O   . LEU A 125 ? 0.34364 0.28970 0.33628 -0.00135 0.03359  -0.00584 119 LEU A O   
938  C CB  . LEU A 125 ? 0.21265 0.31624 0.34412 0.13276  0.05711  -0.03993 119 LEU A CB  
939  C CG  . LEU A 125 ? 0.28187 0.35756 0.37454 0.15445  0.09700  -0.03290 119 LEU A CG  
940  C CD1 . LEU A 125 ? 0.36876 0.38102 0.39648 0.17767  0.12489  -0.02178 119 LEU A CD1 
941  C CD2 . LEU A 125 ? 0.22978 0.38924 0.36495 0.13870  0.07587  -0.04648 119 LEU A CD2 
942  N N   . SER A 126 ? 0.20651 0.32025 0.36602 0.02974  0.02008  -0.04242 120 SER A N   
943  C CA  . SER A 126 ? 0.22695 0.35610 0.38062 0.02028  0.08530  -0.06017 120 SER A CA  
944  C C   . SER A 126 ? 0.22634 0.34645 0.34967 0.02131  0.09439  -0.04217 120 SER A C   
945  O O   . SER A 126 ? 0.17132 0.36092 0.33159 0.01177  0.10405  -0.03536 120 SER A O   
946  C CB  . SER A 126 ? 0.21020 0.39270 0.40363 0.03425  0.11826  -0.06972 120 SER A CB  
947  O OG  . SER A 126 ? 0.20843 0.41005 0.41038 0.02051  0.11289  -0.05519 120 SER A OG  
948  N N   . ASN A 127 ? 0.26540 0.32670 0.35944 0.02085  0.10110  -0.02546 121 ASN A N   
949  C CA  . ASN A 127 ? 0.24712 0.30182 0.32412 0.02214  0.06211  0.01145  121 ASN A CA  
950  C C   . ASN A 127 ? 0.19445 0.28623 0.30696 -0.00290 0.04859  0.00105  121 ASN A C   
951  O O   . ASN A 127 ? 0.21810 0.26939 0.32190 0.02395  0.06307  0.02754  121 ASN A O   
952  C CB  . ASN A 127 ? 0.28429 0.30744 0.32734 -0.01260 0.08466  0.02706  121 ASN A CB  
953  C CG  . ASN A 127 ? 0.29319 0.30648 0.33868 -0.03420 0.08453  0.02871  121 ASN A CG  
954  O OD1 . ASN A 127 ? 0.28553 0.32082 0.35248 -0.01003 0.03685  0.00604  121 ASN A OD1 
955  N ND2 . ASN A 127 ? 0.36124 0.31173 0.36358 -0.05197 0.15360  0.03236  121 ASN A ND2 
956  N N   . ASP A 128 ? 0.21876 0.31112 0.33885 -0.00886 0.09027  0.00399  122 ASP A N   
957  C CA  . ASP A 128 ? 0.20648 0.30748 0.34687 -0.02138 0.07960  0.02686  122 ASP A CA  
958  C C   . ASP A 128 ? 0.20758 0.29324 0.35762 -0.00256 0.10237  0.00928  122 ASP A C   
959  O O   . ASP A 128 ? 0.22852 0.28271 0.36391 0.00391  0.07787  -0.00044 122 ASP A O   
960  C CB  . ASP A 128 ? 0.21599 0.33153 0.37333 -0.01839 0.09661  0.06397  122 ASP A CB  
961  C CG  . ASP A 128 ? 0.26466 0.35909 0.38778 -0.02360 0.09515  0.10723  122 ASP A CG  
962  O OD1 . ASP A 128 ? 0.30974 0.38529 0.43019 -0.04509 0.10816  0.11854  122 ASP A OD1 
963  O OD2 . ASP A 128 ? 0.28907 0.35917 0.37584 -0.00033 0.10574  0.13338  122 ASP A OD2 
964  N N   . HIS A 129 ? 0.17985 0.27707 0.34122 0.02162  0.10602  0.00544  123 HIS A N   
965  C CA  . HIS A 129 ? 0.15011 0.25353 0.29790 0.03764  0.06113  -0.00485 123 HIS A CA  
966  C C   . HIS A 129 ? 0.16212 0.25885 0.26893 0.03336  0.03970  0.00351  123 HIS A C   
967  O O   . HIS A 129 ? 0.19626 0.25778 0.23697 0.02094  0.03421  0.00943  123 HIS A O   
968  C CB  . HIS A 129 ? 0.12579 0.25795 0.33795 0.05201  0.02151  -0.01290 123 HIS A CB  
969  C CG  . HIS A 129 ? 0.13461 0.28838 0.36986 0.06570  0.03666  -0.01173 123 HIS A CG  
970  N ND1 . HIS A 129 ? 0.16751 0.31829 0.38960 0.05932  0.05032  -0.03178 123 HIS A ND1 
971  C CD2 . HIS A 129 ? 0.13214 0.29100 0.36885 0.05501  0.01655  0.00235  123 HIS A CD2 
972  C CE1 . HIS A 129 ? 0.18735 0.32880 0.38423 0.04405  0.03068  -0.01076 123 HIS A CE1 
973  N NE2 . HIS A 129 ? 0.17347 0.30109 0.37488 0.04253  0.04739  0.00280  123 HIS A NE2 
974  N N   . ILE A 130 ? 0.13855 0.25455 0.27150 -0.00916 0.02802  -0.00711 124 ILE A N   
975  C CA  . ILE A 130 ? 0.12715 0.21809 0.25169 0.00517  -0.00337 -0.00167 124 ILE A CA  
976  C C   . ILE A 130 ? 0.19279 0.20559 0.23474 0.01474  0.03162  0.00030  124 ILE A C   
977  O O   . ILE A 130 ? 0.24497 0.19587 0.24199 0.01819  0.07020  0.02778  124 ILE A O   
978  C CB  . ILE A 130 ? 0.11186 0.22446 0.28011 0.01137  0.00913  -0.00134 124 ILE A CB  
979  C CG1 . ILE A 130 ? 0.15372 0.21104 0.29434 0.01629  0.00585  -0.02133 124 ILE A CG1 
980  C CG2 . ILE A 130 ? 0.12877 0.25918 0.27836 -0.00436 0.02776  -0.00185 124 ILE A CG2 
981  C CD1 . ILE A 130 ? 0.22966 0.24416 0.32399 0.02591  0.04740  -0.02046 124 ILE A CD1 
982  N N   . CYS A 131 ? 0.24255 0.17953 0.21224 0.00246  0.05264  -0.00932 125 CYS A N   
983  C CA  . CYS A 131 ? 0.22278 0.20424 0.19187 -0.03784 0.07479  -0.01740 125 CYS A CA  
984  C C   . CYS A 131 ? 0.19963 0.23417 0.21314 -0.00329 0.07825  0.01635  125 CYS A C   
985  O O   . CYS A 131 ? 0.20096 0.22768 0.20053 0.00352  0.08437  0.02143  125 CYS A O   
986  C CB  . CYS A 131 ? 0.23636 0.22844 0.23946 -0.01744 0.08167  0.00213  125 CYS A CB  
987  S SG  . CYS A 131 ? 0.29409 0.26572 0.29587 -0.00114 0.09452  0.03681  125 CYS A SG  
988  N N   . TYR A 132 ? 0.19678 0.26125 0.24403 -0.00849 0.05048  0.01526  126 TYR A N   
989  C CA  . TYR A 132 ? 0.15652 0.24836 0.27080 -0.01173 0.03422  0.03146  126 TYR A CA  
990  C C   . TYR A 132 ? 0.16181 0.21294 0.27526 -0.00379 0.03592  0.04017  126 TYR A C   
991  O O   . TYR A 132 ? 0.17266 0.19529 0.29830 -0.01217 0.04982  0.03930  126 TYR A O   
992  C CB  . TYR A 132 ? 0.15794 0.28825 0.32073 -0.03481 0.04385  0.03028  126 TYR A CB  
993  C CG  . TYR A 132 ? 0.18996 0.31754 0.32061 -0.04106 0.04510  0.02664  126 TYR A CG  
994  C CD1 . TYR A 132 ? 0.26034 0.34834 0.35907 -0.07102 0.05250  0.01851  126 TYR A CD1 
995  C CD2 . TYR A 132 ? 0.20967 0.33140 0.32317 -0.05476 0.04300  0.03360  126 TYR A CD2 
996  C CE1 . TYR A 132 ? 0.27454 0.36095 0.36561 -0.08119 0.00554  0.02463  126 TYR A CE1 
997  C CE2 . TYR A 132 ? 0.25130 0.34842 0.34218 -0.07350 0.01305  0.04026  126 TYR A CE2 
998  C CZ  . TYR A 132 ? 0.32084 0.36539 0.36175 -0.11178 0.00258  0.01628  126 TYR A CZ  
999  O OH  . TYR A 132 ? 0.42767 0.39225 0.40671 -0.11687 -0.00036 0.01983  126 TYR A OH  
1000 N N   . PHE A 133 ? 0.16555 0.20826 0.24599 -0.01580 0.02293  0.03849  127 PHE A N   
1001 C CA  . PHE A 133 ? 0.15057 0.19601 0.25961 -0.00585 0.04444  0.01904  127 PHE A CA  
1002 C C   . PHE A 133 ? 0.15092 0.17721 0.21915 0.01332  0.06023  0.02235  127 PHE A C   
1003 O O   . PHE A 133 ? 0.15518 0.18639 0.20821 0.00555  0.05542  0.02412  127 PHE A O   
1004 C CB  . PHE A 133 ? 0.13175 0.17012 0.26907 0.02160  0.03121  0.02849  127 PHE A CB  
1005 C CG  . PHE A 133 ? 0.11930 0.21788 0.30408 0.02666  0.03171  0.01232  127 PHE A CG  
1006 C CD1 . PHE A 133 ? 0.17455 0.24159 0.33427 0.05641  -0.04156 0.00478  127 PHE A CD1 
1007 C CD2 . PHE A 133 ? 0.15931 0.24079 0.36772 0.04995  0.05108  0.01960  127 PHE A CD2 
1008 C CE1 . PHE A 133 ? 0.24414 0.24610 0.37763 0.07484  0.01387  0.03137  127 PHE A CE1 
1009 C CE2 . PHE A 133 ? 0.20048 0.24915 0.38214 0.04104  0.03783  0.02552  127 PHE A CE2 
1010 C CZ  . PHE A 133 ? 0.22970 0.25414 0.37952 0.05855  0.02508  0.03727  127 PHE A CZ  
1011 N N   . LEU A 134 ? 0.15941 0.20249 0.21665 0.03406  0.02717  0.03477  128 LEU A N   
1012 C CA  . LEU A 134 ? 0.16148 0.18167 0.20228 0.01717  0.01822  0.02159  128 LEU A CA  
1013 C C   . LEU A 134 ? 0.17125 0.16386 0.21633 -0.01655 0.03357  0.01183  128 LEU A C   
1014 O O   . LEU A 134 ? 0.17899 0.15718 0.20663 0.00002  0.03606  0.03265  128 LEU A O   
1015 C CB  . LEU A 134 ? 0.15471 0.19897 0.19854 0.00070  0.00388  0.01839  128 LEU A CB  
1016 C CG  . LEU A 134 ? 0.17466 0.18985 0.19392 -0.00111 0.00137  0.04838  128 LEU A CG  
1017 C CD1 . LEU A 134 ? 0.22198 0.20023 0.21315 -0.02837 0.04415  0.01815  128 LEU A CD1 
1018 C CD2 . LEU A 134 ? 0.21555 0.20753 0.19590 0.00636  0.03094  0.05304  128 LEU A CD2 
1019 N N   . TYR A 135 ? 0.15672 0.15741 0.22215 -0.02735 0.02370  -0.00935 129 TYR A N   
1020 C CA  . TYR A 135 ? 0.18578 0.15173 0.20827 -0.04426 0.02240  0.00515  129 TYR A CA  
1021 C C   . TYR A 135 ? 0.17399 0.17646 0.20278 -0.02022 0.01866  0.03162  129 TYR A C   
1022 O O   . TYR A 135 ? 0.19212 0.16751 0.19312 -0.01833 0.03503  0.02190  129 TYR A O   
1023 C CB  . TYR A 135 ? 0.20459 0.14705 0.22711 -0.05169 0.03403  0.00839  129 TYR A CB  
1024 C CG  . TYR A 135 ? 0.20757 0.16754 0.21314 -0.03035 0.06667  -0.00646 129 TYR A CG  
1025 C CD1 . TYR A 135 ? 0.24022 0.19302 0.20015 -0.03385 0.07212  0.01733  129 TYR A CD1 
1026 C CD2 . TYR A 135 ? 0.19375 0.16595 0.19948 -0.01753 0.06385  0.03032  129 TYR A CD2 
1027 C CE1 . TYR A 135 ? 0.22375 0.20196 0.16520 -0.03289 0.02820  -0.01532 129 TYR A CE1 
1028 C CE2 . TYR A 135 ? 0.19771 0.19066 0.21014 -0.01635 0.04037  0.02283  129 TYR A CE2 
1029 C CZ  . TYR A 135 ? 0.23969 0.19316 0.20232 -0.03670 0.04541  0.00689  129 TYR A CZ  
1030 O OH  . TYR A 135 ? 0.24394 0.19749 0.22407 -0.01566 0.05534  0.01344  129 TYR A OH  
1031 N N   . GLN A 136 ? 0.16197 0.18681 0.16718 -0.04190 -0.01174 0.06891  130 GLN A N   
1032 C CA  . GLN A 136 ? 0.13803 0.20587 0.17146 -0.03661 -0.00717 0.04028  130 GLN A CA  
1033 C C   . GLN A 136 ? 0.14980 0.18927 0.18953 -0.00353 0.01036  0.03557  130 GLN A C   
1034 O O   . GLN A 136 ? 0.17180 0.18576 0.16203 -0.01110 0.02334  0.02741  130 GLN A O   
1035 C CB  . GLN A 136 ? 0.09576 0.21636 0.21377 -0.03379 -0.02389 0.03318  130 GLN A CB  
1036 C CG  . GLN A 136 ? 0.08542 0.24341 0.24503 -0.00308 -0.02645 0.04483  130 GLN A CG  
1037 C CD  . GLN A 136 ? 0.11974 0.26106 0.22315 0.01712  -0.02442 0.03107  130 GLN A CD  
1038 O OE1 . GLN A 136 ? 0.10941 0.27957 0.21966 0.03276  -0.02695 0.05863  130 GLN A OE1 
1039 N NE2 . GLN A 136 ? 0.19193 0.26627 0.23451 0.00841  0.02430  0.01468  130 GLN A NE2 
1040 N N   . ILE A 137 ? 0.11645 0.15957 0.20146 -0.01609 0.00750  0.01913  131 ILE A N   
1041 C CA  . ILE A 137 ? 0.11243 0.14453 0.21887 0.00090  0.02222  0.00480  131 ILE A CA  
1042 C C   . ILE A 137 ? 0.14131 0.15046 0.21137 0.01434  0.03687  0.04077  131 ILE A C   
1043 O O   . ILE A 137 ? 0.15230 0.16707 0.19481 0.00952  0.01607  0.03734  131 ILE A O   
1044 C CB  . ILE A 137 ? 0.10215 0.15141 0.20318 -0.00574 0.01280  -0.00162 131 ILE A CB  
1045 C CG1 . ILE A 137 ? 0.17378 0.14750 0.18913 0.01194  0.01769  -0.02242 131 ILE A CG1 
1046 C CG2 . ILE A 137 ? 0.12678 0.18152 0.20165 -0.00001 0.02823  0.05363  131 ILE A CG2 
1047 C CD1 . ILE A 137 ? 0.15690 0.14303 0.20801 0.01813  0.01219  -0.01713 131 ILE A CD1 
1048 N N   . LEU A 138 ? 0.16615 0.15992 0.18703 0.01569  0.00538  0.04927  132 LEU A N   
1049 C CA  . LEU A 138 ? 0.18580 0.15051 0.15493 0.01951  0.00872  0.03093  132 LEU A CA  
1050 C C   . LEU A 138 ? 0.17650 0.16723 0.17290 0.00373  0.01133  0.02240  132 LEU A C   
1051 O O   . LEU A 138 ? 0.15513 0.16958 0.17006 0.00834  0.01599  0.02882  132 LEU A O   
1052 C CB  . LEU A 138 ? 0.18175 0.17695 0.12164 0.00035  -0.01000 0.02561  132 LEU A CB  
1053 C CG  . LEU A 138 ? 0.16336 0.20173 0.13659 0.02171  0.05736  0.03739  132 LEU A CG  
1054 C CD1 . LEU A 138 ? 0.21486 0.22512 0.16995 0.01715  0.05358  0.06245  132 LEU A CD1 
1055 C CD2 . LEU A 138 ? 0.19264 0.22010 0.18371 0.00524  0.05542  0.02492  132 LEU A CD2 
1056 N N   . ARG A 139 ? 0.15742 0.18098 0.15279 -0.04098 -0.03980 0.01611  133 ARG A N   
1057 C CA  . ARG A 139 ? 0.11541 0.20185 0.17411 -0.03564 -0.00277 0.01754  133 ARG A CA  
1058 C C   . ARG A 139 ? 0.15171 0.19301 0.16600 -0.02269 -0.01670 0.04714  133 ARG A C   
1059 O O   . ARG A 139 ? 0.18035 0.19600 0.18336 -0.01169 0.03135  0.02805  133 ARG A O   
1060 C CB  . ARG A 139 ? 0.13212 0.19643 0.18932 -0.05611 -0.00622 0.02697  133 ARG A CB  
1061 C CG  . ARG A 139 ? 0.11762 0.16472 0.19089 -0.05846 0.00223  0.02547  133 ARG A CG  
1062 C CD  . ARG A 139 ? 0.18782 0.14793 0.21505 -0.06544 0.02363  0.00703  133 ARG A CD  
1063 N NE  . ARG A 139 ? 0.23075 0.17738 0.25253 -0.04997 0.00608  0.00496  133 ARG A NE  
1064 C CZ  . ARG A 139 ? 0.27223 0.17759 0.27562 -0.05052 -0.00984 0.04633  133 ARG A CZ  
1065 N NH1 . ARG A 139 ? 0.29693 0.17356 0.34261 -0.04429 -0.04803 0.04947  133 ARG A NH1 
1066 N NH2 . ARG A 139 ? 0.27155 0.22582 0.23210 -0.07413 0.00599  0.03651  133 ARG A NH2 
1067 N N   . GLY A 140 ? 0.18392 0.15617 0.14047 -0.01936 -0.00805 0.06197  134 GLY A N   
1068 C CA  . GLY A 140 ? 0.14819 0.18673 0.14659 -0.01651 0.03205  0.02728  134 GLY A CA  
1069 C C   . GLY A 140 ? 0.15537 0.18086 0.15023 -0.00488 0.01761  0.02376  134 GLY A C   
1070 O O   . GLY A 140 ? 0.19202 0.16644 0.14837 -0.02544 0.01507  0.00984  134 GLY A O   
1071 N N   . LEU A 141 ? 0.11112 0.20078 0.18923 -0.01168 -0.03005 0.03893  135 LEU A N   
1072 C CA  . LEU A 141 ? 0.10783 0.18069 0.19332 0.00482  -0.04689 0.03166  135 LEU A CA  
1073 C C   . LEU A 141 ? 0.14193 0.16080 0.18328 -0.00724 0.01929  0.05955  135 LEU A C   
1074 O O   . LEU A 141 ? 0.17421 0.17565 0.18234 -0.02290 0.02435  0.01627  135 LEU A O   
1075 C CB  . LEU A 141 ? 0.12326 0.20108 0.16166 -0.02561 -0.02882 0.01289  135 LEU A CB  
1076 C CG  . LEU A 141 ? 0.12761 0.19774 0.14338 -0.01992 0.00350  0.01917  135 LEU A CG  
1077 C CD1 . LEU A 141 ? 0.18032 0.21426 0.16887 -0.01689 0.04042  0.06122  135 LEU A CD1 
1078 C CD2 . LEU A 141 ? 0.17471 0.25315 0.15749 -0.01594 -0.00530 0.00714  135 LEU A CD2 
1079 N N   . LYS A 142 ? 0.19663 0.16072 0.15707 -0.01761 0.02814  0.00143  136 LYS A N   
1080 C CA  . LYS A 142 ? 0.22409 0.13557 0.14856 -0.01636 0.06482  0.02848  136 LYS A CA  
1081 C C   . LYS A 142 ? 0.21060 0.16067 0.15901 -0.01888 0.02296  0.01942  136 LYS A C   
1082 O O   . LYS A 142 ? 0.23016 0.17596 0.18761 -0.01966 0.02196  0.00949  136 LYS A O   
1083 C CB  . LYS A 142 ? 0.20121 0.11682 0.14605 -0.00692 0.00443  0.07186  136 LYS A CB  
1084 C CG  . LYS A 142 ? 0.21230 0.11021 0.18376 -0.00942 0.00176  0.06859  136 LYS A CG  
1085 C CD  . LYS A 142 ? 0.24161 0.12229 0.20213 -0.00947 0.01119  0.04621  136 LYS A CD  
1086 C CE  . LYS A 142 ? 0.25652 0.12356 0.20752 -0.02465 0.02191  0.04099  136 LYS A CE  
1087 N NZ  . LYS A 142 ? 0.24894 0.13300 0.22212 -0.03697 0.03231  0.04578  136 LYS A NZ  
1088 N N   . TYR A 143 ? 0.22709 0.16538 0.12145 -0.02705 -0.01501 0.02198  137 TYR A N   
1089 C CA  . TYR A 143 ? 0.18665 0.19479 0.13803 -0.03336 -0.01340 0.02399  137 TYR A CA  
1090 C C   . TYR A 143 ? 0.22023 0.18792 0.17459 -0.05273 -0.00853 -0.00052 137 TYR A C   
1091 O O   . TYR A 143 ? 0.24634 0.21135 0.17149 -0.01679 0.00474  0.01396  137 TYR A O   
1092 C CB  . TYR A 143 ? 0.19983 0.18856 0.16540 -0.01279 -0.01084 0.02169  137 TYR A CB  
1093 C CG  . TYR A 143 ? 0.20592 0.18823 0.16436 -0.02623 -0.00816 0.01840  137 TYR A CG  
1094 C CD1 . TYR A 143 ? 0.21460 0.19182 0.15227 -0.01968 -0.01156 0.00949  137 TYR A CD1 
1095 C CD2 . TYR A 143 ? 0.23050 0.18878 0.16458 0.00782  0.02967  0.01010  137 TYR A CD2 
1096 C CE1 . TYR A 143 ? 0.26269 0.20963 0.21686 -0.00917 0.02597  -0.02230 137 TYR A CE1 
1097 C CE2 . TYR A 143 ? 0.26681 0.21427 0.16835 -0.00144 0.01486  0.01457  137 TYR A CE2 
1098 C CZ  . TYR A 143 ? 0.27416 0.22688 0.18355 -0.00047 0.00597  -0.01542 137 TYR A CZ  
1099 O OH  . TYR A 143 ? 0.30411 0.24550 0.17304 0.00076  -0.00144 -0.01966 137 TYR A OH  
1100 N N   . ILE A 144 ? 0.21939 0.16139 0.19258 -0.04925 0.00418  -0.00452 138 ILE A N   
1101 C CA  . ILE A 144 ? 0.18227 0.17932 0.18914 -0.03768 0.00256  -0.00132 138 ILE A CA  
1102 C C   . ILE A 144 ? 0.17878 0.18306 0.19104 0.00033  0.03726  0.00677  138 ILE A C   
1103 O O   . ILE A 144 ? 0.17866 0.19892 0.19437 -0.03015 0.03927  -0.02275 138 ILE A O   
1104 C CB  . ILE A 144 ? 0.14470 0.15233 0.19723 -0.02227 -0.00361 -0.00705 138 ILE A CB  
1105 C CG1 . ILE A 144 ? 0.19172 0.15420 0.19738 -0.01710 -0.01137 -0.02192 138 ILE A CG1 
1106 C CG2 . ILE A 144 ? 0.18865 0.16266 0.22161 -0.05918 0.04406  0.03158  138 ILE A CG2 
1107 C CD1 . ILE A 144 ? 0.20655 0.14327 0.20044 -0.01121 0.00248  -0.01858 138 ILE A CD1 
1108 N N   . HIS A 145 ? 0.16145 0.18093 0.17502 -0.00282 0.01749  0.01319  139 HIS A N   
1109 C CA  . HIS A 145 ? 0.16739 0.18564 0.15779 0.02475  0.03865  -0.02527 139 HIS A CA  
1110 C C   . HIS A 145 ? 0.18288 0.18464 0.19796 0.01717  0.03495  -0.02132 139 HIS A C   
1111 O O   . HIS A 145 ? 0.18622 0.21199 0.21568 0.02330  0.02172  0.00005  139 HIS A O   
1112 C CB  . HIS A 145 ? 0.18808 0.18412 0.11404 -0.00256 -0.00675 -0.02565 139 HIS A CB  
1113 C CG  . HIS A 145 ? 0.16432 0.19017 0.16497 -0.00110 0.01764  -0.02734 139 HIS A CG  
1114 N ND1 . HIS A 145 ? 0.17484 0.19741 0.18117 -0.00755 0.02210  0.01173  139 HIS A ND1 
1115 C CD2 . HIS A 145 ? 0.16279 0.19519 0.19100 0.00191  -0.00547 -0.00959 139 HIS A CD2 
1116 C CE1 . HIS A 145 ? 0.18230 0.19970 0.18977 -0.00711 0.00416  0.01955  139 HIS A CE1 
1117 N NE2 . HIS A 145 ? 0.19502 0.20471 0.17583 -0.02139 0.01664  -0.03406 139 HIS A NE2 
1118 N N   . SER A 146 ? 0.21391 0.19075 0.18275 -0.02961 -0.00165 -0.04076 140 SER A N   
1119 C CA  . SER A 146 ? 0.23510 0.19309 0.16841 -0.03915 0.00419  -0.06994 140 SER A CA  
1120 C C   . SER A 146 ? 0.24555 0.21227 0.16178 -0.00809 0.01693  -0.02759 140 SER A C   
1121 O O   . SER A 146 ? 0.26163 0.24593 0.24274 -0.01552 0.07689  -0.04520 140 SER A O   
1122 C CB  . SER A 146 ? 0.21167 0.19927 0.19084 -0.02743 -0.01408 -0.02951 140 SER A CB  
1123 O OG  . SER A 146 ? 0.25012 0.20297 0.23621 -0.05537 0.00822  -0.04013 140 SER A OG  
1124 N N   . ALA A 147 ? 0.25847 0.23504 0.15740 -0.04143 0.04698  -0.01701 141 ALA A N   
1125 C CA  . ALA A 147 ? 0.24780 0.25440 0.18118 -0.03634 0.05684  -0.03929 141 ALA A CA  
1126 C C   . ALA A 147 ? 0.25496 0.26997 0.19737 -0.03719 0.06984  -0.04906 141 ALA A C   
1127 O O   . ALA A 147 ? 0.31236 0.30387 0.21645 -0.04017 0.08868  -0.06331 141 ALA A O   
1128 C CB  . ALA A 147 ? 0.26785 0.26218 0.19007 -0.02946 0.04737  0.00554  141 ALA A CB  
1129 N N   . ASN A 148 ? 0.23866 0.28003 0.21504 -0.03913 0.05459  -0.05615 142 ASN A N   
1130 C CA  . ASN A 148 ? 0.22071 0.28021 0.23348 -0.01140 0.08869  -0.03611 142 ASN A CA  
1131 C C   . ASN A 148 ? 0.20295 0.27848 0.20094 -0.00525 0.10006  -0.00807 142 ASN A C   
1132 O O   . ASN A 148 ? 0.21706 0.27899 0.24048 -0.01759 0.09510  -0.00010 142 ASN A O   
1133 C CB  . ASN A 148 ? 0.24018 0.30849 0.31753 -0.00524 0.10255  -0.04735 142 ASN A CB  
1134 C CG  . ASN A 148 ? 0.23529 0.31759 0.36988 0.05211  0.09308  -0.00026 142 ASN A CG  
1135 O OD1 . ASN A 148 ? 0.22837 0.30894 0.36722 0.03282  0.05472  0.01481  142 ASN A OD1 
1136 N ND2 . ASN A 148 ? 0.25716 0.34714 0.43464 0.07976  0.15556  -0.00047 142 ASN A ND2 
1137 N N   . VAL A 149 ? 0.21317 0.27290 0.20485 0.02009  0.02503  0.00177  143 VAL A N   
1138 C CA  . VAL A 149 ? 0.21641 0.26839 0.19125 0.00388  0.02719  -0.02618 143 VAL A CA  
1139 C C   . VAL A 149 ? 0.18290 0.26237 0.16164 -0.00863 0.02952  -0.02694 143 VAL A C   
1140 O O   . VAL A 149 ? 0.17910 0.27594 0.17307 -0.01984 0.03982  -0.02071 143 VAL A O   
1141 C CB  . VAL A 149 ? 0.23772 0.26651 0.15566 0.00910  0.00113  -0.02856 143 VAL A CB  
1142 C CG1 . VAL A 149 ? 0.23461 0.29008 0.20540 0.02115  -0.00098 -0.00351 143 VAL A CG1 
1143 C CG2 . VAL A 149 ? 0.30957 0.28916 0.12221 -0.01183 0.02809  -0.05915 143 VAL A CG2 
1144 N N   . LEU A 150 ? 0.17859 0.23635 0.17878 -0.00059 0.00306  -0.02117 144 LEU A N   
1145 C CA  . LEU A 150 ? 0.17037 0.23264 0.18296 0.01608  -0.00901 -0.01513 144 LEU A CA  
1146 C C   . LEU A 150 ? 0.18973 0.22977 0.18668 0.00183  0.02492  -0.00860 144 LEU A C   
1147 O O   . LEU A 150 ? 0.23168 0.25307 0.18229 0.00414  0.04380  0.01214  144 LEU A O   
1148 C CB  . LEU A 150 ? 0.19401 0.27064 0.24516 0.05824  -0.02199 -0.00797 144 LEU A CB  
1149 C CG  . LEU A 150 ? 0.20029 0.31108 0.21934 0.02856  0.00058  -0.00370 144 LEU A CG  
1150 C CD1 . LEU A 150 ? 0.18518 0.30221 0.23589 -0.00685 -0.01691 -0.03705 144 LEU A CD1 
1151 C CD2 . LEU A 150 ? 0.21688 0.33517 0.18669 0.03917  -0.02135 0.00319  144 LEU A CD2 
1152 N N   . HIS A 151 ? 0.17349 0.20973 0.20604 0.00895  0.02544  -0.00108 145 HIS A N   
1153 C CA  . HIS A 151 ? 0.16299 0.20575 0.18451 -0.00756 0.03006  -0.00492 145 HIS A CA  
1154 C C   . HIS A 151 ? 0.18630 0.22148 0.19369 -0.03389 0.06580  0.00826  145 HIS A C   
1155 O O   . HIS A 151 ? 0.21660 0.22252 0.16437 -0.04902 0.05407  0.01714  145 HIS A O   
1156 C CB  . HIS A 151 ? 0.13541 0.20495 0.15988 0.01704  0.02430  0.02969  145 HIS A CB  
1157 C CG  . HIS A 151 ? 0.15677 0.19115 0.16192 -0.00242 0.03535  0.03437  145 HIS A CG  
1158 N ND1 . HIS A 151 ? 0.17391 0.18964 0.20084 -0.02668 0.02980  0.03190  145 HIS A ND1 
1159 C CD2 . HIS A 151 ? 0.17284 0.20353 0.17967 0.01779  0.03899  0.06000  145 HIS A CD2 
1160 C CE1 . HIS A 151 ? 0.17646 0.20436 0.20703 -0.02338 -0.01059 0.03837  145 HIS A CE1 
1161 N NE2 . HIS A 151 ? 0.18705 0.20203 0.19583 -0.02254 0.02775  0.04561  145 HIS A NE2 
1162 N N   . ARG A 152 ? 0.17452 0.21176 0.18102 -0.04316 0.03569  -0.01215 146 ARG A N   
1163 C CA  . ARG A 152 ? 0.17690 0.20468 0.18533 -0.02750 0.03115  -0.01484 146 ARG A CA  
1164 C C   . ARG A 152 ? 0.20723 0.22210 0.23429 -0.01762 0.04008  0.00931  146 ARG A C   
1165 O O   . ARG A 152 ? 0.21954 0.26112 0.30470 -0.02288 0.00729  0.00199  146 ARG A O   
1166 C CB  . ARG A 152 ? 0.18622 0.22696 0.21036 0.02605  0.02429  0.00257  146 ARG A CB  
1167 C CG  . ARG A 152 ? 0.23005 0.28340 0.25608 0.04054  0.07959  -0.00896 146 ARG A CG  
1168 C CD  . ARG A 152 ? 0.29758 0.35202 0.28902 0.01286  0.07936  -0.03193 146 ARG A CD  
1169 N NE  . ARG A 152 ? 0.39057 0.39851 0.32025 0.01277  0.07938  -0.05850 146 ARG A NE  
1170 C CZ  . ARG A 152 ? 0.45974 0.42114 0.32495 0.00115  0.04899  -0.07370 146 ARG A CZ  
1171 N NH1 . ARG A 152 ? 0.49542 0.42707 0.32194 0.03034  0.00764  -0.09381 146 ARG A NH1 
1172 N NH2 . ARG A 152 ? 0.38390 0.45186 0.34263 -0.03555 0.03305  -0.08647 146 ARG A NH2 
1173 N N   . ASP A 153 ? 0.18408 0.18233 0.20369 0.01010  0.03249  0.01020  147 ASP A N   
1174 C CA  . ASP A 153 ? 0.22364 0.16378 0.19720 -0.00384 0.03307  0.02774  147 ASP A CA  
1175 C C   . ASP A 153 ? 0.21528 0.16033 0.20544 -0.00651 0.01414  0.02778  147 ASP A C   
1176 O O   . ASP A 153 ? 0.24482 0.15933 0.20182 0.00191  0.03427  0.03716  147 ASP A O   
1177 C CB  . ASP A 153 ? 0.25745 0.18991 0.20399 -0.00167 -0.00039 0.02011  147 ASP A CB  
1178 C CG  . ASP A 153 ? 0.28806 0.22793 0.22978 -0.00771 0.01454  0.05323  147 ASP A CG  
1179 O OD1 . ASP A 153 ? 0.26594 0.23402 0.22546 -0.02150 0.00175  0.05157  147 ASP A OD1 
1180 O OD2 . ASP A 153 ? 0.31330 0.24961 0.26254 0.01151  0.00069  0.04778  147 ASP A OD2 
1181 N N   . LEU A 154 ? 0.18267 0.16993 0.21077 -0.00563 0.02703  0.03461  148 LEU A N   
1182 C CA  . LEU A 154 ? 0.19238 0.16139 0.18495 0.00128  0.03960  0.03229  148 LEU A CA  
1183 C C   . LEU A 154 ? 0.21851 0.17873 0.21064 0.03895  0.05162  0.01921  148 LEU A C   
1184 O O   . LEU A 154 ? 0.23179 0.19237 0.21462 0.02220  0.04472  0.00266  148 LEU A O   
1185 C CB  . LEU A 154 ? 0.21436 0.15986 0.17774 0.00045  0.02918  0.02777  148 LEU A CB  
1186 C CG  . LEU A 154 ? 0.18004 0.15483 0.19906 -0.01357 0.00208  0.01536  148 LEU A CG  
1187 C CD1 . LEU A 154 ? 0.20475 0.16297 0.24359 -0.02042 0.01950  0.05636  148 LEU A CD1 
1188 C CD2 . LEU A 154 ? 0.15823 0.18993 0.22380 -0.02378 -0.00419 0.02787  148 LEU A CD2 
1189 N N   . LYS A 155 ? 0.16788 0.17803 0.18546 0.03840  0.05321  0.02186  149 LYS A N   
1190 C CA  . LYS A 155 ? 0.18429 0.17383 0.19658 0.01655  0.02608  0.03360  149 LYS A CA  
1191 C C   . LYS A 155 ? 0.17404 0.17336 0.17894 0.00533  -0.01337 0.03319  149 LYS A C   
1192 O O   . LYS A 155 ? 0.22666 0.16914 0.18865 -0.02367 -0.00294 0.02629  149 LYS A O   
1193 C CB  . LYS A 155 ? 0.18799 0.20203 0.21579 -0.00637 0.03540  0.06118  149 LYS A CB  
1194 C CG  . LYS A 155 ? 0.19164 0.20318 0.24814 -0.01008 0.03302  0.07241  149 LYS A CG  
1195 C CD  . LYS A 155 ? 0.19050 0.22817 0.29989 -0.02877 0.02229  0.09109  149 LYS A CD  
1196 C CE  . LYS A 155 ? 0.23121 0.24788 0.29696 -0.05426 0.02082  0.11004  149 LYS A CE  
1197 N NZ  . LYS A 155 ? 0.27991 0.26998 0.33803 -0.05288 -0.02839 0.12416  149 LYS A NZ  
1198 N N   . PRO A 156 ? 0.15963 0.18837 0.19636 0.01846  -0.02682 0.01409  150 PRO A N   
1199 C CA  . PRO A 156 ? 0.15309 0.18514 0.18694 0.02924  -0.02697 0.01453  150 PRO A CA  
1200 C C   . PRO A 156 ? 0.18626 0.18331 0.24574 0.02164  -0.01482 0.02318  150 PRO A C   
1201 O O   . PRO A 156 ? 0.20010 0.16975 0.24027 -0.00221 0.00354  0.00424  150 PRO A O   
1202 C CB  . PRO A 156 ? 0.19664 0.19618 0.20693 0.01915  -0.03473 -0.00105 150 PRO A CB  
1203 C CG  . PRO A 156 ? 0.16953 0.18922 0.22252 0.04141  -0.00908 0.01813  150 PRO A CG  
1204 C CD  . PRO A 156 ? 0.17920 0.18202 0.24150 0.00805  0.03370  -0.01959 150 PRO A CD  
1205 N N   . SER A 157 ? 0.16088 0.20510 0.25258 0.03299  -0.02717 0.03146  151 SER A N   
1206 C CA  . SER A 157 ? 0.22931 0.19088 0.26208 0.00754  -0.02581 0.03964  151 SER A CA  
1207 C C   . SER A 157 ? 0.22424 0.20257 0.25771 0.03153  -0.01609 0.03793  151 SER A C   
1208 O O   . SER A 157 ? 0.23348 0.21329 0.29909 0.04765  -0.00972 0.04081  151 SER A O   
1209 C CB  . SER A 157 ? 0.22838 0.20563 0.29216 0.03564  -0.02874 0.05886  151 SER A CB  
1210 O OG  . SER A 157 ? 0.25087 0.20577 0.31010 0.02218  0.00661  0.04567  151 SER A OG  
1211 N N   . ASN A 158 ? 0.24390 0.18608 0.25275 -0.00532 -0.00050 0.04293  152 ASN A N   
1212 C CA  . ASN A 158 ? 0.19996 0.17743 0.21651 0.01183  -0.02131 0.04143  152 ASN A CA  
1213 C C   . ASN A 158 ? 0.21929 0.17540 0.22639 0.02312  0.00615  0.04919  152 ASN A C   
1214 O O   . ASN A 158 ? 0.26323 0.16849 0.23050 0.02195  0.00945  0.03685  152 ASN A O   
1215 C CB  . ASN A 158 ? 0.22368 0.20009 0.24525 0.01636  0.02415  0.02940  152 ASN A CB  
1216 C CG  . ASN A 158 ? 0.18963 0.25359 0.23524 0.01469  0.03303  0.05855  152 ASN A CG  
1217 O OD1 . ASN A 158 ? 0.19790 0.29084 0.25401 0.00208  -0.00595 0.06906  152 ASN A OD1 
1218 N ND2 . ASN A 158 ? 0.18665 0.25087 0.24629 0.00280  -0.00293 0.05450  152 ASN A ND2 
1219 N N   . LEU A 159 ? 0.17871 0.16273 0.22484 0.00537  -0.00988 0.02772  153 LEU A N   
1220 C CA  . LEU A 159 ? 0.14716 0.17702 0.21488 -0.01196 -0.02030 0.02780  153 LEU A CA  
1221 C C   . LEU A 159 ? 0.13515 0.19554 0.24384 0.01309  -0.03192 -0.00571 153 LEU A C   
1222 O O   . LEU A 159 ? 0.19142 0.20168 0.29356 0.03368  -0.04013 -0.00564 153 LEU A O   
1223 C CB  . LEU A 159 ? 0.15602 0.18308 0.19066 0.00950  -0.02954 0.05548  153 LEU A CB  
1224 C CG  . LEU A 159 ? 0.17374 0.18668 0.18070 0.02441  -0.05597 0.02036  153 LEU A CG  
1225 C CD1 . LEU A 159 ? 0.19714 0.18958 0.18591 0.01925  -0.04657 0.03387  153 LEU A CD1 
1226 C CD2 . LEU A 159 ? 0.17543 0.19202 0.23274 0.04720  -0.02421 0.02130  153 LEU A CD2 
1227 N N   . LEU A 160 ? 0.11219 0.21516 0.22951 -0.00358 -0.03595 -0.00441 154 LEU A N   
1228 C CA  . LEU A 160 ? 0.13390 0.23001 0.19927 0.00644  -0.00425 0.00062  154 LEU A CA  
1229 C C   . LEU A 160 ? 0.16089 0.24609 0.22944 0.01622  0.04572  0.01051  154 LEU A C   
1230 O O   . LEU A 160 ? 0.15266 0.22577 0.20460 0.00994  0.00835  0.02275  154 LEU A O   
1231 C CB  . LEU A 160 ? 0.17349 0.23757 0.16649 0.00621  0.01764  0.02022  154 LEU A CB  
1232 C CG  . LEU A 160 ? 0.22014 0.22142 0.22261 -0.01103 0.00460  0.03627  154 LEU A CG  
1233 C CD1 . LEU A 160 ? 0.23152 0.24660 0.22877 -0.02865 -0.03057 0.06620  154 LEU A CD1 
1234 C CD2 . LEU A 160 ? 0.27928 0.20169 0.29451 -0.01156 0.03591  0.01067  154 LEU A CD2 
1235 N N   . LEU A 161 ? 0.14882 0.26338 0.25230 0.02450  0.01977  0.00469  155 LEU A N   
1236 C CA  . LEU A 161 ? 0.16545 0.28934 0.21504 0.00639  0.02184  0.00630  155 LEU A CA  
1237 C C   . LEU A 161 ? 0.16104 0.31982 0.23741 0.01169  0.01912  0.01483  155 LEU A C   
1238 O O   . LEU A 161 ? 0.16646 0.33658 0.29008 0.02004  -0.00397 0.04207  155 LEU A O   
1239 C CB  . LEU A 161 ? 0.21295 0.29048 0.21811 0.06567  -0.00620 0.00332  155 LEU A CB  
1240 C CG  . LEU A 161 ? 0.32300 0.31245 0.23865 0.09624  -0.04882 0.00257  155 LEU A CG  
1241 C CD1 . LEU A 161 ? 0.40106 0.34593 0.31934 0.06506  -0.09409 0.03206  155 LEU A CD1 
1242 C CD2 . LEU A 161 ? 0.29663 0.30739 0.30270 0.07805  -0.09624 0.00288  155 LEU A CD2 
1243 N N   . ASN A 162 ? 0.12855 0.34914 0.22603 -0.02392 -0.04766 -0.00153 156 ASN A N   
1244 C CA  . ASN A 162 ? 0.13801 0.37455 0.27520 -0.01594 -0.02715 0.02628  156 ASN A CA  
1245 C C   . ASN A 162 ? 0.16611 0.38387 0.30311 -0.00675 -0.00467 0.04056  156 ASN A C   
1246 O O   . ASN A 162 ? 0.16958 0.38349 0.30603 0.01570  0.04787  0.04126  156 ASN A O   
1247 C CB  . ASN A 162 ? 0.18978 0.37938 0.31664 -0.00989 -0.04505 0.01830  156 ASN A CB  
1248 C CG  . ASN A 162 ? 0.21783 0.38137 0.39072 0.00324  -0.04585 -0.01067 156 ASN A CG  
1249 O OD1 . ASN A 162 ? 0.16878 0.35187 0.42879 -0.02570 0.03076  0.01065  156 ASN A OD1 
1250 N ND2 . ASN A 162 ? 0.30905 0.40835 0.41653 0.03247  -0.06059 -0.03410 156 ASN A ND2 
1251 N N   . THR A 163 ? 0.16279 0.40598 0.34296 -0.00464 0.02209  0.04854  157 THR A N   
1252 C CA  . THR A 163 ? 0.15015 0.42084 0.34481 -0.00648 0.00170  0.07502  157 THR A CA  
1253 C C   . THR A 163 ? 0.19979 0.41559 0.33748 0.01571  0.01752  0.05479  157 THR A C   
1254 O O   . THR A 163 ? 0.22813 0.39462 0.30577 -0.00229 0.03407  0.02690  157 THR A O   
1255 C CB  A THR A 163 ? 0.15671 0.42662 0.34562 0.01507  -0.03444 0.11331  157 THR A CB  
1256 C CB  B THR A 163 ? 0.20008 0.45614 0.38870 0.00585  0.02708  0.04544  157 THR A CB  
1257 O OG1 A THR A 163 ? 0.16132 0.41345 0.33617 0.01756  -0.06627 0.12111  157 THR A OG1 
1258 O OG1 B THR A 163 ? 0.27769 0.47738 0.41670 -0.00425 0.03986  0.00106  157 THR A OG1 
1259 C CG2 A THR A 163 ? 0.16785 0.42006 0.33276 0.01380  -0.03220 0.12226  157 THR A CG2 
1260 C CG2 B THR A 163 ? 0.12075 0.45094 0.38003 -0.01753 -0.01854 0.04523  157 THR A CG2 
1261 N N   . THR A 164 ? 0.19736 0.40425 0.35816 0.02151  0.01254  0.04649  158 THR A N   
1262 C CA  . THR A 164 ? 0.18281 0.41660 0.37200 0.00528  -0.00860 0.04229  158 THR A CA  
1263 C C   . THR A 164 ? 0.19023 0.41324 0.34343 0.00781  0.03604  0.03946  158 THR A C   
1264 O O   . THR A 164 ? 0.20058 0.42020 0.35451 -0.00050 0.03947  0.08596  158 THR A O   
1265 C CB  . THR A 164 ? 0.17771 0.42849 0.46648 -0.01922 -0.02227 0.01314  158 THR A CB  
1266 O OG1 . THR A 164 ? 0.16249 0.44243 0.50672 -0.00157 -0.03229 -0.02005 158 THR A OG1 
1267 C CG2 . THR A 164 ? 0.26313 0.43995 0.51687 -0.02511 0.01908  0.01600  158 THR A CG2 
1268 N N   . CME A 165 ? 0.15074 0.42271 0.29835 -0.00095 0.03781  0.00446  159 CME A N   
1269 C CA  . CME A 165 ? 0.17016 0.43152 0.27033 0.05486  0.05187  -0.00309 159 CME A CA  
1270 C CB  . CME A 165 ? 0.22070 0.50834 0.26563 0.08797  0.05711  -0.01461 159 CME A CB  
1271 S SG  . CME A 165 ? 0.25425 0.57320 0.29719 0.12695  0.05153  -0.02958 159 CME A SG  
1272 S SD  . CME A 165 ? 0.29954 0.50712 0.31371 0.13797  -0.02867 -0.06918 159 CME A SD  
1273 C CE  . CME A 165 ? 0.30672 0.50525 0.28075 0.12184  -0.02228 -0.06192 159 CME A CE  
1274 C CZ  . CME A 165 ? 0.37063 0.50568 0.28889 0.13366  0.03305  -0.05744 159 CME A CZ  
1275 O OH  . CME A 165 ? 0.38462 0.48569 0.27877 0.16860  0.07238  -0.03946 159 CME A OH  
1276 C C   . CME A 165 ? 0.18185 0.37519 0.25430 0.02397  0.06276  0.01092  159 CME A C   
1277 O O   . CME A 165 ? 0.19403 0.36853 0.26445 0.00726  0.07722  0.02854  159 CME A O   
1278 N N   . ASP A 166 ? 0.16109 0.30807 0.26409 0.01031  0.05109  -0.02447 160 ASP A N   
1279 C CA  . ASP A 166 ? 0.18410 0.27092 0.26321 -0.00209 0.05619  -0.02911 160 ASP A CA  
1280 C C   . ASP A 166 ? 0.16163 0.25199 0.23735 0.00351  0.04511  -0.01778 160 ASP A C   
1281 O O   . ASP A 166 ? 0.17033 0.26971 0.28131 0.01445  0.03518  -0.00331 160 ASP A O   
1282 C CB  . ASP A 166 ? 0.23947 0.30738 0.33798 -0.02355 0.03246  -0.01206 160 ASP A CB  
1283 C CG  . ASP A 166 ? 0.25783 0.32104 0.36894 -0.07627 -0.00773 0.01694  160 ASP A CG  
1284 O OD1 . ASP A 166 ? 0.28654 0.33407 0.45943 -0.06851 0.01682  0.06073  160 ASP A OD1 
1285 O OD2 . ASP A 166 ? 0.21894 0.32183 0.36868 -0.08265 -0.04725 0.01512  160 ASP A OD2 
1286 N N   . LEU A 167 ? 0.15185 0.24478 0.22573 -0.00793 0.02272  0.00479  161 LEU A N   
1287 C CA  . LEU A 167 ? 0.14483 0.23930 0.21002 -0.01436 0.03210  0.02098  161 LEU A CA  
1288 C C   . LEU A 167 ? 0.13036 0.23957 0.20826 0.00048  0.02599  0.04690  161 LEU A C   
1289 O O   . LEU A 167 ? 0.17462 0.26394 0.24028 -0.00126 0.06377  0.07059  161 LEU A O   
1290 C CB  . LEU A 167 ? 0.12703 0.22347 0.22297 -0.00156 -0.00196 0.02777  161 LEU A CB  
1291 C CG  . LEU A 167 ? 0.13556 0.22591 0.22187 -0.01626 0.03315  0.04572  161 LEU A CG  
1292 C CD1 . LEU A 167 ? 0.20389 0.22486 0.24668 0.01631  0.00965  0.05634  161 LEU A CD1 
1293 C CD2 . LEU A 167 ? 0.15196 0.24397 0.22832 -0.01071 0.04074  0.06227  161 LEU A CD2 
1294 N N   . LYS A 168 ? 0.13916 0.25239 0.17400 -0.02224 0.05046  0.04858  162 LYS A N   
1295 C CA  . LYS A 168 ? 0.14089 0.23352 0.17314 -0.03185 0.01400  0.02331  162 LYS A CA  
1296 C C   . LYS A 168 ? 0.15497 0.25497 0.19441 -0.01323 -0.00330 0.02713  162 LYS A C   
1297 O O   . LYS A 168 ? 0.15408 0.25775 0.22129 -0.01532 0.01894  0.01763  162 LYS A O   
1298 C CB  . LYS A 168 ? 0.17791 0.24451 0.21477 -0.06173 -0.02755 0.02220  162 LYS A CB  
1299 C CG  . LYS A 168 ? 0.22762 0.23857 0.24901 -0.08378 -0.02894 0.01180  162 LYS A CG  
1300 C CD  . LYS A 168 ? 0.22612 0.26517 0.29788 -0.07974 -0.02618 0.03283  162 LYS A CD  
1301 C CE  . LYS A 168 ? 0.26268 0.26026 0.37265 -0.06673 0.03450  0.04309  162 LYS A CE  
1302 N NZ  . LYS A 168 ? 0.28297 0.26572 0.41182 -0.06916 0.03196  0.01138  162 LYS A NZ  
1303 N N   . ILE A 169 ? 0.11215 0.24114 0.19144 -0.00069 -0.00541 0.03432  163 ILE A N   
1304 C CA  . ILE A 169 ? 0.12579 0.22317 0.18721 -0.00463 -0.01664 0.04502  163 ILE A CA  
1305 C C   . ILE A 169 ? 0.14860 0.19814 0.19374 0.01656  0.00555  0.04157  163 ILE A C   
1306 O O   . ILE A 169 ? 0.19041 0.20103 0.17360 0.00843  0.01105  0.01189  163 ILE A O   
1307 C CB  . ILE A 169 ? 0.12755 0.19978 0.14049 -0.03849 -0.02772 0.06733  163 ILE A CB  
1308 C CG1 . ILE A 169 ? 0.19122 0.18670 0.15395 -0.00546 0.01619  0.09899  163 ILE A CG1 
1309 C CG2 . ILE A 169 ? 0.13033 0.21803 0.19798 -0.03764 -0.02320 0.03719  163 ILE A CG2 
1310 C CD1 . ILE A 169 ? 0.18805 0.18846 0.19450 0.05547  -0.03805 0.06265  163 ILE A CD1 
1311 N N   . CYS A 170 ? 0.18446 0.18719 0.19657 0.00321  0.00996  0.09490  164 CYS A N   
1312 C CA  . CYS A 170 ? 0.17734 0.21237 0.18793 0.00658  -0.00308 0.09075  164 CYS A CA  
1313 C C   . CYS A 170 ? 0.18750 0.23470 0.19566 0.00912  0.02065  0.08016  164 CYS A C   
1314 O O   . CYS A 170 ? 0.18564 0.23347 0.19570 0.00196  0.00885  0.07512  164 CYS A O   
1315 C CB  . CYS A 170 ? 0.19362 0.21494 0.18310 0.03116  -0.02806 0.09833  164 CYS A CB  
1316 S SG  . CYS A 170 ? 0.21668 0.22862 0.26489 -0.00943 -0.00993 0.06912  164 CYS A SG  
1317 N N   . ASP A 171 ? 0.20651 0.26775 0.17896 -0.00015 0.05935  0.08359  165 ASP A N   
1318 C CA  . ASP A 171 ? 0.25300 0.27227 0.25381 0.02530  0.06867  0.10660  165 ASP A CA  
1319 C C   . ASP A 171 ? 0.27405 0.30512 0.23713 0.02313  0.04068  0.11438  165 ASP A C   
1320 O O   . ASP A 171 ? 0.27204 0.33988 0.23647 0.01112  0.02471  0.09439  165 ASP A O   
1321 C CB  . ASP A 171 ? 0.27334 0.24921 0.26097 0.00685  0.10389  0.08787  165 ASP A CB  
1322 C CG  . ASP A 171 ? 0.26494 0.27911 0.33751 0.01520  0.08694  0.08279  165 ASP A CG  
1323 O OD1 . ASP A 171 ? 0.28066 0.30626 0.34863 0.00488  0.07810  0.14696  165 ASP A OD1 
1324 O OD2 . ASP A 171 ? 0.30793 0.27239 0.39121 -0.03305 0.13511  0.05624  165 ASP A OD2 
1325 N N   . PHE A 172 ? 0.27684 0.31188 0.21524 0.00505  0.06089  0.11017  166 PHE A N   
1326 C CA  . PHE A 172 ? 0.26872 0.30207 0.22322 -0.00893 0.03845  0.12900  166 PHE A CA  
1327 C C   . PHE A 172 ? 0.31584 0.34386 0.25016 0.01584  0.06201  0.13300  166 PHE A C   
1328 O O   . PHE A 172 ? 0.34332 0.35710 0.22941 0.04626  0.05622  0.12291  166 PHE A O   
1329 C CB  . PHE A 172 ? 0.25171 0.27503 0.20709 -0.02683 0.01634  0.08723  166 PHE A CB  
1330 C CG  . PHE A 172 ? 0.24250 0.25053 0.20109 -0.02177 0.01006  0.06825  166 PHE A CG  
1331 C CD1 . PHE A 172 ? 0.21961 0.26843 0.21541 -0.03249 -0.00516 0.08103  166 PHE A CD1 
1332 C CD2 . PHE A 172 ? 0.24086 0.24039 0.19694 -0.05226 -0.01122 0.03854  166 PHE A CD2 
1333 C CE1 . PHE A 172 ? 0.22601 0.27759 0.24047 -0.03448 -0.00813 0.10525  166 PHE A CE1 
1334 C CE2 . PHE A 172 ? 0.19378 0.25436 0.22336 -0.08086 0.01530  0.03631  166 PHE A CE2 
1335 C CZ  . PHE A 172 ? 0.20781 0.27270 0.23541 -0.05392 -0.01940 0.07222  166 PHE A CZ  
1336 N N   . GLY A 173 ? 0.29141 0.33809 0.28381 0.00734  0.07036  0.15765  167 GLY A N   
1337 C CA  . GLY A 173 ? 0.29500 0.35577 0.29434 -0.02258 0.09284  0.15343  167 GLY A CA  
1338 C C   . GLY A 173 ? 0.30813 0.35486 0.27008 -0.02964 0.05992  0.12925  167 GLY A C   
1339 O O   . GLY A 173 ? 0.25971 0.38935 0.27400 -0.00056 0.03747  0.11994  167 GLY A O   
1340 N N   . LEU A 174 ? 0.29981 0.33312 0.20149 -0.01527 0.01231  0.10209  168 LEU A N   
1341 C CA  . LEU A 174 ? 0.37507 0.31727 0.20690 -0.05478 0.05122  0.03935  168 LEU A CA  
1342 C C   . LEU A 174 ? 0.30140 0.32719 0.19202 -0.05655 0.00708  0.02105  168 LEU A C   
1343 O O   . LEU A 174 ? 0.28096 0.33852 0.18007 -0.07721 0.01573  -0.00598 168 LEU A O   
1344 C CB  . LEU A 174 ? 0.51304 0.30554 0.22462 -0.08358 0.07327  0.01728  168 LEU A CB  
1345 C CG  . LEU A 174 ? 0.59453 0.28412 0.22483 -0.10251 0.11103  -0.02766 168 LEU A CG  
1346 C CD1 . LEU A 174 ? 0.58780 0.26120 0.20537 -0.11454 0.12869  -0.03796 168 LEU A CD1 
1347 C CD2 . LEU A 174 ? 0.61938 0.28722 0.20679 -0.08841 0.11119  -0.02420 168 LEU A CD2 
1348 N N   . ALA A 175 ? 0.24050 0.29753 0.17532 -0.05593 0.04440  -0.00561 169 ALA A N   
1349 C CA  . ALA A 175 ? 0.19704 0.29934 0.16448 -0.03357 0.00985  0.01319  169 ALA A CA  
1350 C C   . ALA A 175 ? 0.22668 0.31840 0.18365 -0.02961 0.00934  0.01697  169 ALA A C   
1351 O O   . ALA A 175 ? 0.28996 0.35217 0.20513 -0.02830 0.01612  0.05946  169 ALA A O   
1352 C CB  . ALA A 175 ? 0.23564 0.29779 0.17624 -0.01993 -0.02928 -0.00324 169 ALA A CB  
1353 N N   . ARG A 176 ? 0.21770 0.29718 0.22238 -0.03013 0.00821  0.00928  170 ARG A N   
1354 C CA  A ARG A 176 ? 0.21685 0.29877 0.24057 -0.02630 0.01681  0.00924  170 ARG A CA  
1355 C CA  B ARG A 176 ? 0.22767 0.29764 0.24531 -0.01885 0.03411  -0.00358 170 ARG A CA  
1356 C C   . ARG A 176 ? 0.23794 0.30552 0.24718 -0.03144 0.05115  -0.02634 170 ARG A C   
1357 O O   . ARG A 176 ? 0.24317 0.30717 0.23876 -0.01272 0.08015  -0.03815 170 ARG A O   
1358 C CB  A ARG A 176 ? 0.21750 0.31284 0.28067 -0.05885 -0.01339 0.04493  170 ARG A CB  
1359 C CB  B ARG A 176 ? 0.25034 0.31069 0.29977 -0.03804 0.04116  0.00834  170 ARG A CB  
1360 C CG  A ARG A 176 ? 0.25157 0.32780 0.30980 -0.07171 -0.00611 0.05515  170 ARG A CG  
1361 C CG  B ARG A 176 ? 0.29254 0.32215 0.34196 -0.03099 0.07683  -0.00773 170 ARG A CG  
1362 C CD  A ARG A 176 ? 0.30951 0.34060 0.33220 -0.06942 0.01301  0.04920  170 ARG A CD  
1363 C CD  B ARG A 176 ? 0.33241 0.33099 0.37337 -0.01597 0.11273  -0.03081 170 ARG A CD  
1364 N NE  A ARG A 176 ? 0.33794 0.34703 0.35256 -0.06174 0.02325  0.03191  170 ARG A NE  
1365 N NE  B ARG A 176 ? 0.43696 0.34764 0.43654 -0.00935 0.18450  -0.03396 170 ARG A NE  
1366 C CZ  A ARG A 176 ? 0.35264 0.36026 0.36410 -0.06056 0.04893  0.03293  170 ARG A CZ  
1367 C CZ  B ARG A 176 ? 0.46454 0.36008 0.49458 0.00212  0.23640  -0.02005 170 ARG A CZ  
1368 N NH1 A ARG A 176 ? 0.32305 0.35657 0.35788 -0.04226 0.06547  0.03713  170 ARG A NH1 
1369 N NH1 B ARG A 176 ? 0.48696 0.35686 0.51917 -0.02652 0.24319  -0.01029 170 ARG A NH1 
1370 N NH2 A ARG A 176 ? 0.36999 0.37413 0.38999 -0.06523 0.08241  0.04582  170 ARG A NH2 
1371 N NH2 B ARG A 176 ? 0.45581 0.36605 0.50091 0.03547  0.24142  -0.03341 170 ARG A NH2 
1372 N N   . VAL A 177 ? 0.21760 0.30072 0.27046 -0.00907 0.06666  -0.03012 171 VAL A N   
1373 C CA  . VAL A 177 ? 0.22564 0.32161 0.26302 -0.02628 0.06602  -0.04418 171 VAL A CA  
1374 C C   . VAL A 177 ? 0.18458 0.33843 0.28081 -0.03643 0.08160  -0.01198 171 VAL A C   
1375 O O   . VAL A 177 ? 0.21166 0.35603 0.31649 -0.02145 0.07242  -0.03727 171 VAL A O   
1376 C CB  . VAL A 177 ? 0.31909 0.34766 0.28731 -0.03531 0.09027  -0.04445 171 VAL A CB  
1377 C CG1 . VAL A 177 ? 0.39008 0.33528 0.31075 -0.02983 0.10182  -0.04085 171 VAL A CG1 
1378 C CG2 . VAL A 177 ? 0.34206 0.36208 0.29095 -0.03671 0.06656  -0.02968 171 VAL A CG2 
1379 N N   . ALA A 178 ? 0.20878 0.35237 0.28595 -0.00642 0.07099  -0.01194 172 ALA A N   
1380 C CA  . ALA A 178 ? 0.19245 0.35788 0.28253 0.01342  0.07647  -0.01389 172 ALA A CA  
1381 C C   . ALA A 178 ? 0.19827 0.35760 0.32715 0.01236  0.06308  -0.07498 172 ALA A C   
1382 O O   . ALA A 178 ? 0.20316 0.34470 0.35872 0.04238  0.03527  -0.10758 172 ALA A O   
1383 C CB  . ALA A 178 ? 0.20199 0.35181 0.27510 0.01816  0.08935  0.02923  172 ALA A CB  
1384 N N   . ASP A 179 ? 0.19621 0.36373 0.33660 0.00218  0.06346  -0.07348 173 ASP A N   
1385 C CA  . ASP A 179 ? 0.23835 0.39174 0.40124 -0.00193 0.06576  -0.11525 173 ASP A CA  
1386 C C   . ASP A 179 ? 0.22794 0.38079 0.40388 0.00606  0.02130  -0.11441 173 ASP A C   
1387 O O   . ASP A 179 ? 0.21192 0.38611 0.40223 0.01951  0.04142  -0.10529 173 ASP A O   
1388 C CB  . ASP A 179 ? 0.24350 0.43432 0.45157 -0.02012 0.11009  -0.13347 173 ASP A CB  
1389 C CG  . ASP A 179 ? 0.29098 0.48984 0.50274 -0.03337 0.10006  -0.13618 173 ASP A CG  
1390 O OD1 . ASP A 179 ? 0.29984 0.50381 0.54398 -0.02588 0.09126  -0.14966 173 ASP A OD1 
1391 O OD2 . ASP A 179 ? 0.31654 0.52323 0.48907 -0.05052 0.12254  -0.14053 173 ASP A OD2 
1392 N N   . PRO A 180 ? 0.27394 0.37701 0.42917 -0.01481 -0.02235 -0.11123 174 PRO A N   
1393 C CA  . PRO A 180 ? 0.31382 0.38486 0.47169 -0.00280 -0.03406 -0.10139 174 PRO A CA  
1394 C C   . PRO A 180 ? 0.30816 0.38902 0.51930 0.04666  -0.06997 -0.13291 174 PRO A C   
1395 O O   . PRO A 180 ? 0.34444 0.38540 0.52906 0.07848  -0.11735 -0.13921 174 PRO A O   
1396 C CB  . PRO A 180 ? 0.38997 0.37738 0.47593 -0.00918 -0.01080 -0.07169 174 PRO A CB  
1397 C CG  . PRO A 180 ? 0.38848 0.37996 0.45009 -0.01527 -0.02165 -0.06676 174 PRO A CG  
1398 C CD  . PRO A 180 ? 0.33292 0.37396 0.42917 -0.02862 -0.02096 -0.08093 174 PRO A CD  
1399 N N   . ASP A 181 ? 0.26861 0.39928 0.57015 0.05785  -0.00993 -0.15172 175 ASP A N   
1400 C CA  . ASP A 181 ? 0.26747 0.43177 0.59568 0.05975  -0.02076 -0.16478 175 ASP A CA  
1401 C C   . ASP A 181 ? 0.22715 0.45583 0.59346 0.04217  -0.02014 -0.18207 175 ASP A C   
1402 O O   . ASP A 181 ? 0.20569 0.49327 0.62079 0.04804  -0.07278 -0.18672 175 ASP A O   
1403 C CB  . ASP A 181 ? 0.31460 0.44301 0.62088 0.06615  0.00690  -0.16584 175 ASP A CB  
1404 C CG  . ASP A 181 ? 0.37594 0.45732 0.63258 0.05955  0.01010  -0.16195 175 ASP A CG  
1405 O OD1 . ASP A 181 ? 0.39874 0.46578 0.63890 0.06132  0.01804  -0.13058 175 ASP A OD1 
1406 O OD2 . ASP A 181 ? 0.39548 0.45414 0.63541 0.05890  0.01270  -0.18159 175 ASP A OD2 
1407 N N   . HIS A 182 ? 0.23850 0.44798 0.54401 0.02334  0.04353  -0.19151 176 HIS A N   
1408 C CA  . HIS A 182 ? 0.24877 0.45990 0.51123 -0.00195 0.06674  -0.17264 176 HIS A CA  
1409 C C   . HIS A 182 ? 0.27019 0.43103 0.47115 -0.00528 0.10275  -0.12105 176 HIS A C   
1410 O O   . HIS A 182 ? 0.32856 0.47352 0.49226 -0.02461 0.15218  -0.09280 176 HIS A O   
1411 C CB  . HIS A 182 ? 0.26111 0.49963 0.53220 -0.01679 0.06783  -0.19911 176 HIS A CB  
1412 C CG  . HIS A 182 ? 0.24331 0.52109 0.56791 -0.00651 0.07764  -0.22688 176 HIS A CG  
1413 N ND1 . HIS A 182 ? 0.24402 0.53415 0.57248 0.00438  0.07013  -0.25182 176 HIS A ND1 
1414 C CD2 . HIS A 182 ? 0.22859 0.52520 0.57511 0.02399  0.06890  -0.22496 176 HIS A CD2 
1415 C CE1 . HIS A 182 ? 0.26013 0.53845 0.57846 0.00016  0.08877  -0.25134 176 HIS A CE1 
1416 N NE2 . HIS A 182 ? 0.26290 0.53598 0.57620 -0.00147 0.07990  -0.25724 176 HIS A NE2 
1417 N N   . ASP A 183 ? 0.21563 0.38799 0.38417 -0.01521 0.06395  -0.11659 177 ASP A N   
1418 C CA  . ASP A 183 ? 0.20720 0.38808 0.35061 -0.01123 0.06611  -0.09949 177 ASP A CA  
1419 C C   . ASP A 183 ? 0.20133 0.39405 0.34468 0.00626  0.04341  -0.08600 177 ASP A C   
1420 O O   . ASP A 183 ? 0.23434 0.37548 0.30554 0.01860  0.01118  -0.11239 177 ASP A O   
1421 C CB  . ASP A 183 ? 0.18291 0.39046 0.37036 -0.01446 0.06372  -0.08300 177 ASP A CB  
1422 C CG  . ASP A 183 ? 0.21546 0.38824 0.37164 -0.02252 0.03476  -0.08854 177 ASP A CG  
1423 O OD1 . ASP A 183 ? 0.18929 0.39552 0.39900 0.01671  0.00005  -0.11129 177 ASP A OD1 
1424 O OD2 . ASP A 183 ? 0.25999 0.40097 0.37903 -0.01722 0.08080  -0.05192 177 ASP A OD2 
1425 N N   . HIS A 184 ? 0.19644 0.40182 0.33949 0.01482  -0.00297 -0.05852 178 HIS A N   
1426 C CA  . HIS A 184 ? 0.21293 0.38511 0.30016 -0.00128 -0.01362 -0.05510 178 HIS A CA  
1427 C C   . HIS A 184 ? 0.25963 0.36111 0.30001 -0.00528 0.02569  -0.07834 178 HIS A C   
1428 O O   . HIS A 184 ? 0.27033 0.35285 0.30306 -0.00148 0.04299  -0.08725 178 HIS A O   
1429 C CB  . HIS A 184 ? 0.25764 0.40656 0.31790 0.04138  -0.01437 0.00195  178 HIS A CB  
1430 C CG  . HIS A 184 ? 0.32023 0.42904 0.32902 0.06695  0.04219  0.03266  178 HIS A CG  
1431 N ND1 . HIS A 184 ? 0.37033 0.44442 0.33112 0.05723  0.06604  0.03866  178 HIS A ND1 
1432 C CD2 . HIS A 184 ? 0.34496 0.43668 0.33279 0.08858  0.06291  0.05371  178 HIS A CD2 
1433 C CE1 . HIS A 184 ? 0.40010 0.44803 0.34147 0.06122  0.08505  0.05698  178 HIS A CE1 
1434 N NE2 . HIS A 184 ? 0.39083 0.44428 0.34002 0.07898  0.09602  0.04896  178 HIS A NE2 
1435 N N   . THR A 185 ? 0.26794 0.34339 0.30298 -0.00998 0.04183  -0.06789 179 THR A N   
1436 C CA  . THR A 185 ? 0.25800 0.33697 0.30607 -0.01977 0.06195  -0.07096 179 THR A CA  
1437 C C   . THR A 185 ? 0.22164 0.34034 0.35184 -0.00316 0.04528  -0.06453 179 THR A C   
1438 O O   . THR A 185 ? 0.21773 0.34172 0.34169 0.00142  0.05480  -0.07202 179 THR A O   
1439 C CB  . THR A 185 ? 0.27104 0.34015 0.31608 -0.03967 0.06940  -0.02649 179 THR A CB  
1440 O OG1 . THR A 185 ? 0.30031 0.36013 0.29293 -0.06370 0.04133  0.00130  179 THR A OG1 
1441 C CG2 . THR A 185 ? 0.27684 0.32253 0.33787 -0.05964 0.09659  -0.01386 179 THR A CG2 
1442 N N   . GLY A 186 ? 0.23095 0.31821 0.36297 -0.03391 0.04639  -0.09089 180 GLY A N   
1443 C CA  . GLY A 186 ? 0.23584 0.31643 0.33785 -0.00034 0.04360  -0.08572 180 GLY A CA  
1444 C C   . GLY A 186 ? 0.24139 0.30709 0.34263 -0.01361 0.00614  -0.05027 180 GLY A C   
1445 O O   . GLY A 186 ? 0.25238 0.31944 0.36303 -0.00253 -0.02864 -0.03455 180 GLY A O   
1446 N N   . PHE A 187 ? 0.26460 0.31353 0.32379 -0.01209 0.01073  -0.02770 181 PHE A N   
1447 C CA  . PHE A 187 ? 0.25154 0.29653 0.28983 -0.03596 -0.00436 -0.00631 181 PHE A CA  
1448 C C   . PHE A 187 ? 0.26266 0.32374 0.28050 -0.05778 -0.04204 0.01122  181 PHE A C   
1449 O O   . PHE A 187 ? 0.33666 0.33399 0.32111 -0.06971 0.05466  0.04639  181 PHE A O   
1450 C CB  . PHE A 187 ? 0.23300 0.27283 0.26331 -0.02007 -0.03233 -0.00985 181 PHE A CB  
1451 C CG  . PHE A 187 ? 0.28009 0.25294 0.27528 0.00014  0.00273  0.00983  181 PHE A CG  
1452 C CD1 . PHE A 187 ? 0.25269 0.25122 0.27302 0.03998  -0.00806 0.03225  181 PHE A CD1 
1453 C CD2 . PHE A 187 ? 0.32383 0.26418 0.27479 -0.02313 0.02138  -0.00577 181 PHE A CD2 
1454 C CE1 . PHE A 187 ? 0.28291 0.25820 0.28450 0.01464  0.01076  0.00805  181 PHE A CE1 
1455 C CE2 . PHE A 187 ? 0.30240 0.25756 0.27073 -0.00517 0.00440  0.02283  181 PHE A CE2 
1456 C CZ  . PHE A 187 ? 0.29185 0.27928 0.24774 -0.00106 -0.01446 0.02199  181 PHE A CZ  
1457 N N   . LEU A 188 ? 0.28312 0.34569 0.28818 0.00345  -0.05329 0.03500  182 LEU A N   
1458 C CA  . LEU A 188 ? 0.34248 0.37325 0.28360 -0.03513 -0.07422 0.04025  182 LEU A CA  
1459 C C   . LEU A 188 ? 0.30526 0.42406 0.29471 -0.06049 -0.09116 0.04677  182 LEU A C   
1460 O O   . LEU A 188 ? 0.34819 0.46427 0.32132 -0.05572 -0.09935 0.06522  182 LEU A O   
1461 C CB  . LEU A 188 ? 0.45027 0.37934 0.31248 -0.04800 -0.09908 0.03875  182 LEU A CB  
1462 C CG  . LEU A 188 ? 0.53138 0.36493 0.35185 -0.04840 -0.09701 0.02881  182 LEU A CG  
1463 C CD1 . LEU A 188 ? 0.57984 0.36597 0.36805 -0.07224 -0.12034 0.01979  182 LEU A CD1 
1464 C CD2 . LEU A 188 ? 0.53133 0.33882 0.35247 -0.00711 -0.05963 0.04738  182 LEU A CD2 
1465 N N   . THR A 189 ? 0.24289 0.45001 0.28007 -0.07357 -0.08809 0.01683  183 THR A N   
1466 C CA  . THR A 189 ? 0.26596 0.46844 0.31187 -0.06449 -0.04712 0.00973  183 THR A CA  
1467 C C   . THR A 189 ? 0.25566 0.44334 0.32163 -0.05989 -0.04457 0.06741  183 THR A C   
1468 O O   . THR A 189 ? 0.25242 0.42174 0.36436 -0.04730 0.01975  0.09110  183 THR A O   
1469 C CB  . THR A 189 ? 0.28236 0.49731 0.31458 -0.05134 0.00530  -0.01047 183 THR A CB  
1470 O OG1 . THR A 189 ? 0.22515 0.50432 0.34173 -0.03064 0.05435  -0.00862 183 THR A OG1 
1471 C CG2 . THR A 189 ? 0.27269 0.51970 0.28958 -0.06476 -0.01026 -0.01212 183 THR A CG2 
1472 N N   . GLU A 190 ? 0.24792 0.45021 0.33253 -0.08253 -0.09812 0.09945  184 GLU A N   
1473 C CA  . GLU A 190 ? 0.31395 0.47989 0.36005 -0.13064 -0.05604 0.10761  184 GLU A CA  
1474 C C   . GLU A 190 ? 0.33503 0.50766 0.40957 -0.11585 0.00485  0.10483  184 GLU A C   
1475 O O   . GLU A 190 ? 0.36048 0.50922 0.45406 -0.11536 0.04369  0.09581  184 GLU A O   
1476 C CB  . GLU A 190 ? 0.37755 0.49986 0.36424 -0.12411 -0.02858 0.14027  184 GLU A CB  
1477 C CG  . GLU A 190 ? 0.40694 0.48995 0.37433 -0.14821 0.00443  0.15171  184 GLU A CG  
1478 C CD  . GLU A 190 ? 0.45839 0.49830 0.38507 -0.13959 0.06116  0.14361  184 GLU A CD  
1479 O OE1 . GLU A 190 ? 0.48074 0.51439 0.39022 -0.12939 0.09567  0.13170  184 GLU A OE1 
1480 O OE2 . GLU A 190 ? 0.47994 0.49629 0.38600 -0.14007 0.08350  0.15087  184 GLU A OE2 
1481 N N   . TYR A 191 ? 0.37117 0.52610 0.38822 -0.08247 -0.02005 0.09707  185 TYR A N   
1482 C CA  . TYR A 191 ? 0.34904 0.51480 0.38320 -0.11023 -0.03712 0.09182  185 TYR A CA  
1483 C C   . TYR A 191 ? 0.36945 0.53007 0.41343 -0.06457 -0.01561 0.10549  185 TYR A C   
1484 O O   . TYR A 191 ? 0.42802 0.53747 0.44033 -0.04971 0.01550  0.09457  185 TYR A O   
1485 C CB  . TYR A 191 ? 0.38299 0.49429 0.38251 -0.13380 -0.03149 0.08037  185 TYR A CB  
1486 C CG  . TYR A 191 ? 0.36837 0.46388 0.40316 -0.15679 0.00429  0.05714  185 TYR A CG  
1487 C CD1 . TYR A 191 ? 0.37332 0.45860 0.38352 -0.14368 0.00047  0.04492  185 TYR A CD1 
1488 C CD2 . TYR A 191 ? 0.35008 0.46114 0.42057 -0.12597 -0.07226 0.06042  185 TYR A CD2 
1489 C CE1 . TYR A 191 ? 0.31595 0.44569 0.36152 -0.13642 -0.05454 0.02807  185 TYR A CE1 
1490 C CE2 . TYR A 191 ? 0.34463 0.46915 0.42795 -0.15611 -0.04789 0.05172  185 TYR A CE2 
1491 C CZ  . TYR A 191 ? 0.32881 0.45545 0.37654 -0.16005 -0.06180 0.02606  185 TYR A CZ  
1492 O OH  . TYR A 191 ? 0.35924 0.47760 0.40199 -0.11214 -0.06034 0.04850  185 TYR A OH  
1493 N N   . VAL A 192 ? 0.33217 0.53382 0.42260 -0.07860 0.01495  0.11517  186 VAL A N   
1494 C CA  . VAL A 192 ? 0.35176 0.54048 0.41283 -0.04999 0.01710  0.12999  186 VAL A CA  
1495 C C   . VAL A 192 ? 0.35598 0.48419 0.43495 -0.04945 0.03118  0.13125  186 VAL A C   
1496 O O   . VAL A 192 ? 0.39197 0.51321 0.47693 -0.05532 0.04760  0.12570  186 VAL A O   
1497 C CB  . VAL A 192 ? 0.37378 0.58647 0.45303 -0.04709 0.03786  0.12583  186 VAL A CB  
1498 C CG1 . VAL A 192 ? 0.38351 0.60092 0.47530 -0.03568 0.04719  0.12759  186 VAL A CG1 
1499 C CG2 . VAL A 192 ? 0.38000 0.59479 0.46144 -0.06023 0.07284  0.14409  186 VAL A CG2 
1500 N N   . ALA A 193 ? 0.34383 0.40569 0.39808 -0.05437 0.03650  0.11201  187 ALA A N   
1501 C CA  . ALA A 193 ? 0.32925 0.35095 0.37999 -0.03322 0.05042  0.07142  187 ALA A CA  
1502 C C   . ALA A 193 ? 0.29985 0.31732 0.36756 -0.01305 0.02444  0.00814  187 ALA A C   
1503 O O   . ALA A 193 ? 0.33692 0.32302 0.38117 -0.00114 0.03362  0.05320  187 ALA A O   
1504 C CB  . ALA A 193 ? 0.38717 0.30165 0.35225 -0.05819 0.03859  0.08596  187 ALA A CB  
1505 N N   . THR A 194 ? 0.28533 0.32096 0.36879 -0.02499 -0.03242 -0.04033 188 THR A N   
1506 C CA  . THR A 194 ? 0.26264 0.28088 0.30409 -0.02606 -0.06531 -0.01376 188 THR A CA  
1507 C C   . THR A 194 ? 0.30601 0.25186 0.31184 -0.04682 -0.10269 0.00779  188 THR A C   
1508 O O   . THR A 194 ? 0.37333 0.26586 0.31762 -0.03547 -0.15027 0.01646  188 THR A O   
1509 C CB  . THR A 194 ? 0.22697 0.26785 0.26080 -0.04225 -0.05018 0.01296  188 THR A CB  
1510 O OG1 . THR A 194 ? 0.26107 0.26038 0.23644 -0.05174 -0.02619 0.05394  188 THR A OG1 
1511 C CG2 . THR A 194 ? 0.23862 0.26427 0.27328 -0.01176 0.00475  0.02509  188 THR A CG2 
1512 N N   . ARG A 195 ? 0.28900 0.22074 0.30429 -0.08387 -0.11494 0.00959  189 ARG A N   
1513 C CA  . ARG A 195 ? 0.32018 0.20100 0.31923 -0.11675 -0.10398 0.03771  189 ARG A CA  
1514 C C   . ARG A 195 ? 0.26179 0.18709 0.33595 -0.09625 -0.09577 0.05004  189 ARG A C   
1515 O O   . ARG A 195 ? 0.26988 0.18943 0.34421 -0.05875 -0.08817 0.04858  189 ARG A O   
1516 C CB  . ARG A 195 ? 0.41324 0.21506 0.33859 -0.13938 -0.10209 0.04345  189 ARG A CB  
1517 C CG  . ARG A 195 ? 0.46514 0.21960 0.32138 -0.14857 -0.12005 0.04625  189 ARG A CG  
1518 C CD  . ARG A 195 ? 0.56749 0.21921 0.34570 -0.12399 -0.07960 0.08340  189 ARG A CD  
1519 N NE  . ARG A 195 ? 0.61369 0.22749 0.39545 -0.14775 -0.07334 0.05793  189 ARG A NE  
1520 C CZ  . ARG A 195 ? 0.65499 0.23888 0.39394 -0.11805 -0.08491 0.09672  189 ARG A CZ  
1521 N NH1 . ARG A 195 ? 0.63064 0.24385 0.38641 -0.15523 -0.12648 0.06961  189 ARG A NH1 
1522 N NH2 . ARG A 195 ? 0.68396 0.23963 0.40507 -0.07310 -0.06090 0.11303  189 ARG A NH2 
1523 N N   . TRP A 196 ? 0.24744 0.18726 0.35997 -0.07237 -0.05088 0.03592  190 TRP A N   
1524 C CA  . TRP A 196 ? 0.27537 0.18113 0.35833 -0.03403 -0.05783 0.03795  190 TRP A CA  
1525 C C   . TRP A 196 ? 0.23726 0.17455 0.30934 -0.02190 -0.07202 0.03354  190 TRP A C   
1526 O O   . TRP A 196 ? 0.23476 0.18912 0.32856 -0.01680 -0.06143 0.01761  190 TRP A O   
1527 C CB  . TRP A 196 ? 0.27008 0.16585 0.37076 -0.00749 -0.07373 0.00221  190 TRP A CB  
1528 C CG  . TRP A 196 ? 0.27230 0.19268 0.37620 0.01035  -0.10090 0.01293  190 TRP A CG  
1529 C CD1 . TRP A 196 ? 0.32467 0.20508 0.38690 0.02013  -0.08805 -0.01140 190 TRP A CD1 
1530 C CD2 . TRP A 196 ? 0.28567 0.20819 0.44123 0.03111  -0.09337 0.02060  190 TRP A CD2 
1531 N NE1 . TRP A 196 ? 0.33177 0.21151 0.43463 0.04439  -0.08794 0.01241  190 TRP A NE1 
1532 C CE2 . TRP A 196 ? 0.28196 0.21782 0.46742 0.04887  -0.09701 0.00667  190 TRP A CE2 
1533 C CE3 . TRP A 196 ? 0.24720 0.21008 0.44805 0.04223  -0.12701 0.02360  190 TRP A CE3 
1534 C CZ2 . TRP A 196 ? 0.27219 0.23258 0.48797 0.04867  -0.09623 0.01181  190 TRP A CZ2 
1535 C CZ3 . TRP A 196 ? 0.30018 0.19604 0.49380 0.07012  -0.05192 0.00790  190 TRP A CZ3 
1536 C CH2 . TRP A 196 ? 0.29222 0.21558 0.50442 0.04375  -0.04228 -0.01042 190 TRP A CH2 
1537 N N   . TYR A 197 ? 0.21836 0.17390 0.26137 -0.02109 -0.06730 0.04527  191 TYR A N   
1538 C CA  . TYR A 197 ? 0.20565 0.18741 0.23888 -0.01613 -0.05035 0.05719  191 TYR A CA  
1539 C C   . TYR A 197 ? 0.23160 0.20248 0.23374 -0.01517 -0.00569 0.06112  191 TYR A C   
1540 O O   . TYR A 197 ? 0.21170 0.20001 0.21149 -0.00975 0.02514  0.02535  191 TYR A O   
1541 C CB  . TYR A 197 ? 0.21957 0.19540 0.24574 -0.02061 -0.06138 0.01962  191 TYR A CB  
1542 C CG  . TYR A 197 ? 0.24878 0.20419 0.25885 -0.01890 -0.05308 0.03956  191 TYR A CG  
1543 C CD1 . TYR A 197 ? 0.23983 0.23434 0.27097 -0.02205 -0.03913 0.03057  191 TYR A CD1 
1544 C CD2 . TYR A 197 ? 0.23667 0.19309 0.25561 -0.01868 -0.09412 0.03194  191 TYR A CD2 
1545 C CE1 . TYR A 197 ? 0.19488 0.23646 0.24246 -0.01239 -0.07028 0.02928  191 TYR A CE1 
1546 C CE2 . TYR A 197 ? 0.25025 0.22327 0.28161 -0.03634 -0.04178 0.04650  191 TYR A CE2 
1547 C CZ  . TYR A 197 ? 0.20073 0.22984 0.28550 -0.01547 -0.04915 0.03774  191 TYR A CZ  
1548 O OH  . TYR A 197 ? 0.22707 0.23162 0.31299 0.00034  -0.03649 0.03617  191 TYR A OH  
1549 N N   . ARG A 198 ? 0.21671 0.21406 0.23564 -0.06043 -0.02692 0.04204  192 ARG A N   
1550 C CA  . ARG A 198 ? 0.22301 0.22058 0.25447 -0.05336 0.01055  0.04149  192 ARG A CA  
1551 C C   . ARG A 198 ? 0.16823 0.24815 0.21706 -0.01612 -0.00550 0.02663  192 ARG A C   
1552 O O   . ARG A 198 ? 0.20967 0.26899 0.20827 -0.02570 0.00373  0.01559  192 ARG A O   
1553 C CB  . ARG A 198 ? 0.32694 0.20113 0.29907 -0.08769 0.03487  0.03192  192 ARG A CB  
1554 C CG  . ARG A 198 ? 0.33747 0.19874 0.32655 -0.07074 0.08028  0.05241  192 ARG A CG  
1555 C CD  . ARG A 198 ? 0.25885 0.18078 0.28625 -0.06087 0.03753  0.06087  192 ARG A CD  
1556 N NE  . ARG A 198 ? 0.24925 0.22597 0.29328 -0.02744 0.01010  0.07131  192 ARG A NE  
1557 C CZ  . ARG A 198 ? 0.37627 0.26947 0.30244 -0.05146 -0.06177 0.06034  192 ARG A CZ  
1558 N NH1 . ARG A 198 ? 0.42565 0.27612 0.31574 -0.08620 -0.07821 0.07875  192 ARG A NH1 
1559 N NH2 . ARG A 198 ? 0.43598 0.31681 0.33665 -0.02214 -0.04804 0.01532  192 ARG A NH2 
1560 N N   . ALA A 199 ? 0.14536 0.23385 0.21680 -0.02146 -0.00362 0.04269  193 ALA A N   
1561 C CA  . ALA A 199 ? 0.12276 0.24243 0.19673 -0.01691 -0.00318 -0.02152 193 ALA A CA  
1562 C C   . ALA A 199 ? 0.14852 0.27696 0.20908 -0.03161 0.01292  -0.00387 193 ALA A C   
1563 O O   . ALA A 199 ? 0.17789 0.26253 0.21659 -0.02623 0.03578  0.00270  193 ALA A O   
1564 C CB  . ALA A 199 ? 0.16352 0.23622 0.18052 -0.02074 0.01742  -0.06596 193 ALA A CB  
1565 N N   . PRO A 200 ? 0.13505 0.29665 0.20813 -0.03976 0.02056  -0.01896 194 PRO A N   
1566 C CA  . PRO A 200 ? 0.14191 0.30823 0.19981 -0.00374 0.01143  -0.02093 194 PRO A CA  
1567 C C   . PRO A 200 ? 0.13988 0.30582 0.20712 -0.02507 0.01483  0.00780  194 PRO A C   
1568 O O   . PRO A 200 ? 0.14782 0.31087 0.22949 -0.03374 0.02097  -0.00244 194 PRO A O   
1569 C CB  . PRO A 200 ? 0.13328 0.30318 0.20702 -0.05084 0.00832  -0.03637 194 PRO A CB  
1570 C CG  . PRO A 200 ? 0.17075 0.29002 0.19264 -0.05460 -0.02865 -0.05346 194 PRO A CG  
1571 C CD  . PRO A 200 ? 0.14485 0.28183 0.19230 -0.03650 0.00540  0.00017  194 PRO A CD  
1572 N N   . GLU A 201 ? 0.15545 0.29943 0.22089 -0.00463 0.02633  -0.01814 195 GLU A N   
1573 C CA  . GLU A 201 ? 0.16833 0.30759 0.21271 -0.02418 0.02297  -0.00377 195 GLU A CA  
1574 C C   . GLU A 201 ? 0.17958 0.30133 0.21261 -0.05294 0.03371  -0.01603 195 GLU A C   
1575 O O   . GLU A 201 ? 0.15989 0.31901 0.23351 -0.04121 0.06032  -0.01063 195 GLU A O   
1576 C CB  . GLU A 201 ? 0.15744 0.30830 0.20229 -0.02210 0.00798  0.01384  195 GLU A CB  
1577 C CG  . GLU A 201 ? 0.13841 0.30808 0.21907 -0.04354 0.01473  0.01140  195 GLU A CG  
1578 C CD  . GLU A 201 ? 0.16072 0.29923 0.24523 -0.01391 0.03348  -0.01430 195 GLU A CD  
1579 O OE1 . GLU A 201 ? 0.21181 0.29267 0.22885 -0.01834 0.06007  -0.00972 195 GLU A OE1 
1580 O OE2 . GLU A 201 ? 0.17380 0.29759 0.23573 -0.01821 0.04063  0.00410  195 GLU A OE2 
1581 N N   . ILE A 202 ? 0.20873 0.30324 0.18121 -0.01774 0.00854  -0.00168 196 ILE A N   
1582 C CA  . ILE A 202 ? 0.16706 0.33196 0.16823 -0.02188 -0.02684 0.01597  196 ILE A CA  
1583 C C   . ILE A 202 ? 0.20333 0.35740 0.19752 -0.03420 -0.00337 -0.00866 196 ILE A C   
1584 O O   . ILE A 202 ? 0.22631 0.37264 0.19202 -0.04911 -0.00971 -0.00336 196 ILE A O   
1585 C CB  . ILE A 202 ? 0.19491 0.33338 0.19215 -0.00299 -0.03236 0.00748  196 ILE A CB  
1586 C CG1 . ILE A 202 ? 0.21735 0.32891 0.20177 -0.00596 -0.00124 -0.02463 196 ILE A CG1 
1587 C CG2 . ILE A 202 ? 0.19665 0.35530 0.23452 0.00235  0.03528  0.02793  196 ILE A CG2 
1588 C CD1 . ILE A 202 ? 0.24204 0.34680 0.21242 0.00424  -0.02905 -0.03109 196 ILE A CD1 
1589 N N   . MET A 203 ? 0.20054 0.34232 0.22734 -0.02582 0.01108  -0.02959 197 MET A N   
1590 C CA  . MET A 203 ? 0.17785 0.33591 0.25555 -0.03092 -0.02448 -0.02999 197 MET A CA  
1591 C C   . MET A 203 ? 0.18166 0.33591 0.25672 -0.03631 -0.02089 -0.01863 197 MET A C   
1592 O O   . MET A 203 ? 0.22448 0.34312 0.32917 -0.04425 0.01721  0.03158  197 MET A O   
1593 C CB  . MET A 203 ? 0.20523 0.34569 0.27467 -0.03815 -0.01727 -0.00516 197 MET A CB  
1594 C CG  . MET A 203 ? 0.22338 0.35882 0.29520 -0.04474 -0.01917 0.00017  197 MET A CG  
1595 S SD  . MET A 203 ? 0.23684 0.36502 0.27410 -0.02908 -0.00264 0.01511  197 MET A SD  
1596 C CE  . MET A 203 ? 0.26840 0.36814 0.22810 -0.02671 0.02802  0.05189  197 MET A CE  
1597 N N   . LEU A 204 ? 0.18671 0.34357 0.21295 -0.00058 0.03331  -0.02044 198 LEU A N   
1598 C CA  . LEU A 204 ? 0.15711 0.35368 0.20766 -0.03126 0.05066  -0.03456 198 LEU A CA  
1599 C C   . LEU A 204 ? 0.17189 0.38859 0.21936 -0.02993 0.03462  -0.03615 198 LEU A C   
1600 O O   . LEU A 204 ? 0.18213 0.41940 0.22544 -0.03400 0.01570  -0.04044 198 LEU A O   
1601 C CB  . LEU A 204 ? 0.24531 0.34834 0.19341 -0.01661 0.07553  -0.00124 198 LEU A CB  
1602 C CG  . LEU A 204 ? 0.18950 0.33238 0.22240 -0.04969 0.06587  -0.00331 198 LEU A CG  
1603 C CD1 . LEU A 204 ? 0.23664 0.31632 0.22776 -0.04504 0.05869  0.04486  198 LEU A CD1 
1604 C CD2 . LEU A 204 ? 0.18998 0.34819 0.23949 -0.05947 0.01249  -0.00681 198 LEU A CD2 
1605 N N   . ASN A 205 ? 0.17328 0.36899 0.22569 -0.00844 0.03686  -0.02983 199 ASN A N   
1606 C CA  . ASN A 205 ? 0.20218 0.36958 0.26322 0.00775  0.02573  -0.02177 199 ASN A CA  
1607 C C   . ASN A 205 ? 0.18367 0.34406 0.26747 -0.01684 0.03386  -0.04924 199 ASN A C   
1608 O O   . ASN A 205 ? 0.20245 0.33044 0.28238 0.02192  0.08053  -0.07492 199 ASN A O   
1609 C CB  . ASN A 205 ? 0.21195 0.36675 0.26529 0.00723  0.03727  0.00793  199 ASN A CB  
1610 C CG  . ASN A 205 ? 0.24769 0.37455 0.27546 0.03826  0.03733  -0.00128 199 ASN A CG  
1611 O OD1 . ASN A 205 ? 0.25741 0.38227 0.29234 0.03771  0.04438  0.00975  199 ASN A OD1 
1612 N ND2 . ASN A 205 ? 0.26293 0.37894 0.26579 0.03926  0.00766  0.00297  199 ASN A ND2 
1613 N N   . SER A 206 ? 0.17660 0.33615 0.24838 -0.02306 0.01129  -0.03837 200 SER A N   
1614 C CA  . SER A 206 ? 0.17703 0.32697 0.25379 -0.02555 0.02033  -0.05455 200 SER A CA  
1615 C C   . SER A 206 ? 0.20637 0.33720 0.22343 -0.02801 0.03396  -0.05249 200 SER A C   
1616 O O   . SER A 206 ? 0.21983 0.36309 0.24816 -0.00593 0.07564  -0.04004 200 SER A O   
1617 C CB  . SER A 206 ? 0.19647 0.34329 0.26904 -0.04003 0.06681  -0.04493 200 SER A CB  
1618 O OG  . SER A 206 ? 0.20442 0.34131 0.28251 0.00186  0.03010  -0.01504 200 SER A OG  
1619 N N   . LYS A 207 ? 0.19717 0.34139 0.20435 -0.02304 0.00909  -0.04401 201 LYS A N   
1620 C CA  . LYS A 207 ? 0.23092 0.35803 0.25251 -0.01164 0.04682  -0.04695 201 LYS A CA  
1621 C C   . LYS A 207 ? 0.21375 0.33865 0.27019 0.01210  0.04825  -0.00901 201 LYS A C   
1622 O O   . LYS A 207 ? 0.21446 0.34735 0.30315 -0.00016 0.03985  0.00564  201 LYS A O   
1623 C CB  . LYS A 207 ? 0.22792 0.38787 0.25283 -0.00047 0.07279  -0.06946 201 LYS A CB  
1624 C CG  . LYS A 207 ? 0.27910 0.43173 0.30356 0.00831  0.10073  -0.11109 201 LYS A CG  
1625 C CD  . LYS A 207 ? 0.29039 0.44958 0.34710 0.01080  0.16186  -0.10147 201 LYS A CD  
1626 C CE  . LYS A 207 ? 0.33460 0.47165 0.36284 0.01195  0.17320  -0.12187 201 LYS A CE  
1627 N NZ  . LYS A 207 ? 0.39082 0.50346 0.37753 0.00353  0.17365  -0.14003 201 LYS A NZ  
1628 N N   . GLY A 208 ? 0.20040 0.32187 0.25450 -0.00146 0.02231  -0.00987 202 GLY A N   
1629 C CA  . GLY A 208 ? 0.22850 0.33366 0.26171 -0.01151 0.01351  -0.04743 202 GLY A CA  
1630 C C   . GLY A 208 ? 0.21750 0.35663 0.24456 0.00013  0.01329  -0.05575 202 GLY A C   
1631 O O   . GLY A 208 ? 0.27106 0.35435 0.27057 0.00274  0.01254  -0.04417 202 GLY A O   
1632 N N   . TYR A 209 ? 0.19501 0.36860 0.24613 0.01506  0.05850  -0.05810 203 TYR A N   
1633 C CA  . TYR A 209 ? 0.17153 0.38259 0.22570 -0.02202 0.06942  -0.05729 203 TYR A CA  
1634 C C   . TYR A 209 ? 0.19121 0.40891 0.24414 -0.03941 0.05371  -0.05316 203 TYR A C   
1635 O O   . TYR A 209 ? 0.20050 0.42390 0.24957 -0.03389 0.04229  -0.04614 203 TYR A O   
1636 C CB  . TYR A 209 ? 0.18186 0.40256 0.26909 -0.03204 0.10845  -0.04258 203 TYR A CB  
1637 C CG  . TYR A 209 ? 0.27317 0.45199 0.29183 -0.05520 0.09209  -0.05002 203 TYR A CG  
1638 C CD1 . TYR A 209 ? 0.28131 0.46898 0.29766 -0.06530 0.08741  -0.01400 203 TYR A CD1 
1639 C CD2 . TYR A 209 ? 0.28699 0.46745 0.31627 -0.06104 0.06159  -0.02193 203 TYR A CD2 
1640 C CE1 . TYR A 209 ? 0.36051 0.48730 0.33451 -0.09710 0.11435  0.00979  203 TYR A CE1 
1641 C CE2 . TYR A 209 ? 0.29962 0.48268 0.33729 -0.06950 0.09190  -0.02713 203 TYR A CE2 
1642 C CZ  . TYR A 209 ? 0.41962 0.49599 0.36904 -0.10139 0.14628  -0.01153 203 TYR A CZ  
1643 O OH  . TYR A 209 ? 0.54278 0.50137 0.40275 -0.10772 0.17086  -0.01875 203 TYR A OH  
1644 N N   . THR A 210 ? 0.18368 0.39364 0.20621 -0.05567 0.01998  -0.02645 204 THR A N   
1645 C CA  . THR A 210 ? 0.18327 0.38901 0.28860 -0.03938 0.03290  -0.02279 204 THR A CA  
1646 C C   . THR A 210 ? 0.16144 0.34334 0.25579 -0.01427 0.04763  -0.02650 204 THR A C   
1647 O O   . THR A 210 ? 0.19376 0.36205 0.22843 -0.01606 0.05123  -0.00842 204 THR A O   
1648 C CB  A THR A 210 ? 0.19197 0.42847 0.35956 -0.02076 0.00893  -0.05334 204 THR A CB  
1649 C CB  B THR A 210 ? 0.20297 0.39497 0.29243 -0.03158 0.03451  -0.00685 204 THR A CB  
1650 O OG1 A THR A 210 ? 0.27388 0.47714 0.40245 -0.02382 -0.01877 -0.05170 204 THR A OG1 
1651 O OG1 B THR A 210 ? 0.21492 0.39704 0.29201 -0.02454 0.03443  0.00966  204 THR A OG1 
1652 C CG2 A THR A 210 ? 0.14086 0.43309 0.38417 0.02047  -0.00660 -0.05044 204 THR A CG2 
1653 C CG2 B THR A 210 ? 0.21676 0.40127 0.29387 -0.02394 0.03227  -0.00297 204 THR A CG2 
1654 N N   . LYS A 211 ? 0.14873 0.30354 0.22717 -0.01353 0.03507  -0.02647 205 LYS A N   
1655 C CA  . LYS A 211 ? 0.16141 0.26276 0.21518 -0.00809 0.05310  -0.05314 205 LYS A CA  
1656 C C   . LYS A 211 ? 0.14658 0.24733 0.20966 0.01066  0.04932  -0.02638 205 LYS A C   
1657 O O   . LYS A 211 ? 0.15684 0.22227 0.21006 0.01434  0.04028  -0.01927 205 LYS A O   
1658 C CB  . LYS A 211 ? 0.20391 0.27042 0.22087 -0.03130 0.03217  -0.07235 205 LYS A CB  
1659 C CG  . LYS A 211 ? 0.22194 0.25060 0.21890 -0.00073 0.01520  -0.05948 205 LYS A CG  
1660 C CD  . LYS A 211 ? 0.24102 0.23805 0.24602 0.02517  0.00855  -0.05399 205 LYS A CD  
1661 C CE  . LYS A 211 ? 0.25315 0.23831 0.26444 0.02831  0.02584  -0.08099 205 LYS A CE  
1662 N NZ  . LYS A 211 ? 0.25317 0.26722 0.28574 0.04239  0.02454  -0.04256 205 LYS A NZ  
1663 N N   . SER A 212 ? 0.15211 0.25692 0.16688 -0.01333 0.01719  -0.03564 206 SER A N   
1664 C CA  . SER A 212 ? 0.16464 0.28080 0.19884 -0.01414 0.02533  -0.01947 206 SER A CA  
1665 C C   . SER A 212 ? 0.14851 0.26532 0.18733 -0.02320 0.01855  0.03032  206 SER A C   
1666 O O   . SER A 212 ? 0.18605 0.26685 0.17766 -0.01427 0.00576  0.01843  206 SER A O   
1667 C CB  . SER A 212 ? 0.17325 0.32524 0.23563 -0.02829 0.03254  -0.03072 206 SER A CB  
1668 O OG  . SER A 212 ? 0.20580 0.37488 0.25657 0.03105  0.01280  -0.04434 206 SER A OG  
1669 N N   . ILE A 213 ? 0.16311 0.26440 0.19416 -0.01351 0.00027  0.05020  207 ILE A N   
1670 C CA  . ILE A 213 ? 0.13581 0.27174 0.18935 -0.03301 -0.00152 0.06722  207 ILE A CA  
1671 C C   . ILE A 213 ? 0.14252 0.24994 0.20924 -0.03118 0.03592  0.03251  207 ILE A C   
1672 O O   . ILE A 213 ? 0.17495 0.24923 0.18956 -0.01867 0.01883  0.02737  207 ILE A O   
1673 C CB  . ILE A 213 ? 0.19479 0.31017 0.24261 -0.06867 0.00888  0.05647  207 ILE A CB  
1674 C CG1 . ILE A 213 ? 0.31426 0.33910 0.27675 -0.06751 0.07392  0.05900  207 ILE A CG1 
1675 C CG2 . ILE A 213 ? 0.21601 0.32136 0.27274 -0.04601 0.03363  0.03505  207 ILE A CG2 
1676 C CD1 . ILE A 213 ? 0.30850 0.34625 0.28110 -0.03995 0.01326  0.05373  207 ILE A CD1 
1677 N N   . ASP A 214 ? 0.10300 0.23174 0.19495 -0.01410 -0.00856 0.01567  208 ASP A N   
1678 C CA  . ASP A 214 ? 0.11879 0.21390 0.17383 -0.02573 0.00197  0.01932  208 ASP A CA  
1679 C C   . ASP A 214 ? 0.15626 0.21226 0.15736 -0.01312 0.01182  0.02481  208 ASP A C   
1680 O O   . ASP A 214 ? 0.14166 0.21618 0.15106 -0.01330 0.01020  0.01993  208 ASP A O   
1681 C CB  . ASP A 214 ? 0.15341 0.19167 0.15218 -0.03984 -0.00997 0.02668  208 ASP A CB  
1682 C CG  . ASP A 214 ? 0.17821 0.20339 0.15825 -0.00247 -0.01359 0.01860  208 ASP A CG  
1683 O OD1 . ASP A 214 ? 0.17813 0.19789 0.15999 -0.01309 0.00812  0.02327  208 ASP A OD1 
1684 O OD2 . ASP A 214 ? 0.19904 0.23809 0.15091 -0.01011 0.01873  -0.01130 208 ASP A OD2 
1685 N N   . ILE A 215 ? 0.14702 0.19530 0.12209 0.00624  0.01289  0.02069  209 ILE A N   
1686 C CA  . ILE A 215 ? 0.16078 0.16789 0.14106 -0.00195 0.02272  0.01336  209 ILE A CA  
1687 C C   . ILE A 215 ? 0.16300 0.18293 0.18318 -0.00940 0.03022  0.00169  209 ILE A C   
1688 O O   . ILE A 215 ? 0.17421 0.16377 0.20171 0.02786  0.06296  0.01914  209 ILE A O   
1689 C CB  . ILE A 215 ? 0.15824 0.18007 0.16012 0.02072  0.00324  0.01037  209 ILE A CB  
1690 C CG1 . ILE A 215 ? 0.17551 0.18466 0.19242 -0.00188 -0.01212 -0.00997 209 ILE A CG1 
1691 C CG2 . ILE A 215 ? 0.18488 0.22003 0.16491 0.02012  0.00488  0.02470  209 ILE A CG2 
1692 C CD1 . ILE A 215 ? 0.17305 0.18722 0.22411 -0.01387 -0.03495 -0.01100 209 ILE A CD1 
1693 N N   . TRP A 216 ? 0.15128 0.18075 0.19466 -0.00900 -0.01470 0.00763  210 TRP A N   
1694 C CA  . TRP A 216 ? 0.12513 0.18514 0.20539 0.01006  0.01224  -0.00047 210 TRP A CA  
1695 C C   . TRP A 216 ? 0.14365 0.19050 0.17593 -0.00074 0.01959  0.01431  210 TRP A C   
1696 O O   . TRP A 216 ? 0.15528 0.18984 0.18654 0.00537  0.03262  0.00220  210 TRP A O   
1697 C CB  . TRP A 216 ? 0.13605 0.17923 0.16664 0.00125  0.02930  -0.01891 210 TRP A CB  
1698 C CG  . TRP A 216 ? 0.13916 0.18991 0.17416 0.00442  0.01052  0.00107  210 TRP A CG  
1699 C CD1 . TRP A 216 ? 0.15165 0.20217 0.16420 -0.00479 0.02788  -0.01848 210 TRP A CD1 
1700 C CD2 . TRP A 216 ? 0.13909 0.20619 0.16490 0.02171  0.01636  -0.00026 210 TRP A CD2 
1701 N NE1 . TRP A 216 ? 0.17367 0.23245 0.18216 -0.00495 0.02319  -0.01925 210 TRP A NE1 
1702 C CE2 . TRP A 216 ? 0.15217 0.22875 0.18261 0.00715  0.00975  -0.00215 210 TRP A CE2 
1703 C CE3 . TRP A 216 ? 0.15082 0.22465 0.16101 0.01494  0.01847  0.00053  210 TRP A CE3 
1704 C CZ2 . TRP A 216 ? 0.17144 0.24544 0.17142 0.00229  0.02446  -0.00880 210 TRP A CZ2 
1705 C CZ3 . TRP A 216 ? 0.13262 0.21661 0.20045 -0.00824 0.00863  -0.03431 210 TRP A CZ3 
1706 C CH2 . TRP A 216 ? 0.17558 0.22093 0.20477 0.01029  0.03071  -0.00653 210 TRP A CH2 
1707 N N   . SER A 217 ? 0.13760 0.19732 0.16010 -0.00460 -0.04610 0.02563  211 SER A N   
1708 C CA  . SER A 217 ? 0.14971 0.20332 0.14431 -0.00069 -0.02581 0.03977  211 SER A CA  
1709 C C   . SER A 217 ? 0.18272 0.18464 0.15571 -0.01715 0.02366  0.03748  211 SER A C   
1710 O O   . SER A 217 ? 0.18094 0.20088 0.19900 -0.01631 -0.00212 0.03301  211 SER A O   
1711 C CB  . SER A 217 ? 0.12629 0.21532 0.15386 -0.03490 -0.00416 0.01872  211 SER A CB  
1712 O OG  . SER A 217 ? 0.14310 0.23083 0.18344 -0.03503 0.00660  0.01660  211 SER A OG  
1713 N N   . VAL A 218 ? 0.16612 0.15169 0.16063 -0.02812 0.01483  0.04819  212 VAL A N   
1714 C CA  . VAL A 218 ? 0.17185 0.17144 0.18406 -0.02845 0.05439  0.00995  212 VAL A CA  
1715 C C   . VAL A 218 ? 0.16014 0.17657 0.17290 -0.00876 0.04535  0.00254  212 VAL A C   
1716 O O   . VAL A 218 ? 0.15524 0.19150 0.17872 0.00420  0.03649  0.00949  212 VAL A O   
1717 C CB  . VAL A 218 ? 0.14509 0.17865 0.18662 -0.03709 0.04519  -0.03081 212 VAL A CB  
1718 C CG1 . VAL A 218 ? 0.17829 0.21544 0.18150 -0.04563 0.06435  -0.03697 212 VAL A CG1 
1719 C CG2 . VAL A 218 ? 0.20900 0.18197 0.19947 -0.01973 0.05350  -0.02171 212 VAL A CG2 
1720 N N   . GLY A 219 ? 0.19168 0.16714 0.13652 -0.02327 0.02020  -0.01274 213 GLY A N   
1721 C CA  . GLY A 219 ? 0.16149 0.14992 0.13715 0.00586  0.04373  -0.02621 213 GLY A CA  
1722 C C   . GLY A 219 ? 0.17221 0.18251 0.20684 -0.00202 0.05625  0.00292  213 GLY A C   
1723 O O   . GLY A 219 ? 0.13952 0.21197 0.20968 -0.00588 0.03393  0.01685  213 GLY A O   
1724 N N   . CYS A 220 ? 0.14791 0.14551 0.19157 -0.00509 0.01245  0.02703  214 CYS A N   
1725 C CA  . CYS A 220 ? 0.14083 0.18088 0.21771 -0.01039 0.03278  0.03460  214 CYS A CA  
1726 C C   . CYS A 220 ? 0.12343 0.20815 0.19896 -0.02943 0.00299  0.01271  214 CYS A C   
1727 O O   . CYS A 220 ? 0.16286 0.21543 0.21731 -0.01219 -0.00172 0.00675  214 CYS A O   
1728 C CB  . CYS A 220 ? 0.11896 0.18797 0.21605 -0.03174 0.03017  0.00742  214 CYS A CB  
1729 S SG  . CYS A 220 ? 0.15523 0.20018 0.23860 -0.01041 0.03022  -0.00379 214 CYS A SG  
1730 N N   . ILE A 221 ? 0.12084 0.22272 0.18216 -0.01673 -0.01557 0.01462  215 ILE A N   
1731 C CA  . ILE A 221 ? 0.12570 0.21485 0.20006 0.01012  0.02157  0.02867  215 ILE A CA  
1732 C C   . ILE A 221 ? 0.12498 0.19422 0.20105 0.00651  -0.00746 0.00847  215 ILE A C   
1733 O O   . ILE A 221 ? 0.15296 0.20112 0.23930 0.03757  0.04216  0.00602  215 ILE A O   
1734 C CB  . ILE A 221 ? 0.11606 0.24378 0.17358 -0.02016 -0.00696 0.01980  215 ILE A CB  
1735 C CG1 . ILE A 221 ? 0.14855 0.24735 0.16944 -0.00152 0.01908  -0.00358 215 ILE A CG1 
1736 C CG2 . ILE A 221 ? 0.15551 0.25679 0.20884 -0.00098 0.00265  0.01759  215 ILE A CG2 
1737 C CD1 . ILE A 221 ? 0.15158 0.28177 0.14826 0.02614  0.01549  0.01040  215 ILE A CD1 
1738 N N   . LEU A 222 ? 0.15830 0.19409 0.19873 0.00335  0.01729  0.01129  216 LEU A N   
1739 C CA  . LEU A 222 ? 0.19026 0.18927 0.18364 -0.00731 0.04701  0.00495  216 LEU A CA  
1740 C C   . LEU A 222 ? 0.19049 0.19449 0.22006 -0.00240 0.04167  -0.00430 216 LEU A C   
1741 O O   . LEU A 222 ? 0.15204 0.19094 0.21258 0.01292  0.03951  -0.01241 216 LEU A O   
1742 C CB  . LEU A 222 ? 0.20677 0.20935 0.16030 0.00622  0.04788  0.04701  216 LEU A CB  
1743 C CG  . LEU A 222 ? 0.16355 0.23498 0.16590 0.01406  0.01890  0.02952  216 LEU A CG  
1744 C CD1 . LEU A 222 ? 0.16592 0.26686 0.15810 -0.01538 -0.01122 0.01459  216 LEU A CD1 
1745 C CD2 . LEU A 222 ? 0.22368 0.22508 0.19971 0.00721  0.02367  0.03495  216 LEU A CD2 
1746 N N   . ALA A 223 ? 0.18605 0.19496 0.19154 -0.02721 -0.00312 -0.01903 217 ALA A N   
1747 C CA  . ALA A 223 ? 0.18463 0.19094 0.20713 -0.02079 0.01886  -0.04437 217 ALA A CA  
1748 C C   . ALA A 223 ? 0.20155 0.20482 0.25485 0.01163  0.06312  -0.04111 217 ALA A C   
1749 O O   . ALA A 223 ? 0.20300 0.21193 0.26808 0.04094  0.02751  -0.03350 217 ALA A O   
1750 C CB  . ALA A 223 ? 0.16872 0.21300 0.21511 -0.04110 0.04601  -0.03703 217 ALA A CB  
1751 N N   . GLU A 224 ? 0.18295 0.19156 0.25725 0.00935  0.02219  -0.00282 218 GLU A N   
1752 C CA  . GLU A 224 ? 0.17067 0.19928 0.26036 0.00029  0.03375  0.02219  218 GLU A CA  
1753 C C   . GLU A 224 ? 0.15850 0.22205 0.27968 0.01145  0.01443  -0.00016 218 GLU A C   
1754 O O   . GLU A 224 ? 0.26119 0.24097 0.31484 0.01567  0.03937  0.01564  218 GLU A O   
1755 C CB  . GLU A 224 ? 0.21898 0.19399 0.25006 0.03958  0.02800  0.05280  218 GLU A CB  
1756 C CG  . GLU A 224 ? 0.24951 0.19695 0.26853 0.00823  0.02260  0.05574  218 GLU A CG  
1757 C CD  . GLU A 224 ? 0.25631 0.22246 0.30388 0.01897  0.01270  0.05200  218 GLU A CD  
1758 O OE1 . GLU A 224 ? 0.23510 0.21909 0.32166 0.01884  0.00143  0.03326  218 GLU A OE1 
1759 O OE2 . GLU A 224 ? 0.25550 0.23097 0.35195 0.02475  -0.02437 0.03402  218 GLU A OE2 
1760 N N   . MET A 225 ? 0.13541 0.24662 0.27678 0.00751  0.02890  -0.00823 219 MET A N   
1761 C CA  . MET A 225 ? 0.16527 0.25775 0.25722 0.05169  0.05077  -0.00700 219 MET A CA  
1762 C C   . MET A 225 ? 0.19170 0.27957 0.30412 0.07072  0.07620  -0.00397 219 MET A C   
1763 O O   . MET A 225 ? 0.18485 0.30750 0.31551 0.04782  0.08231  -0.01994 219 MET A O   
1764 C CB  . MET A 225 ? 0.19304 0.24007 0.23543 0.04197  0.03747  0.01972  219 MET A CB  
1765 C CG  . MET A 225 ? 0.16798 0.22647 0.26666 0.04244  0.03595  -0.00326 219 MET A CG  
1766 S SD  . MET A 225 ? 0.18173 0.21555 0.30882 0.01584  0.00740  0.00414  219 MET A SD  
1767 C CE  . MET A 225 ? 0.21619 0.22128 0.27592 0.03410  -0.00239 -0.04244 219 MET A CE  
1768 N N   . LEU A 226 ? 0.21651 0.27174 0.27147 0.02851  0.05998  -0.01744 220 LEU A N   
1769 C CA  . LEU A 226 ? 0.24935 0.28573 0.30822 0.04643  0.07330  -0.01382 220 LEU A CA  
1770 C C   . LEU A 226 ? 0.28239 0.29824 0.32862 0.04410  0.06802  -0.04970 220 LEU A C   
1771 O O   . LEU A 226 ? 0.34795 0.32599 0.36501 0.02391  0.12960  -0.05919 220 LEU A O   
1772 C CB  . LEU A 226 ? 0.25903 0.29041 0.30873 0.05247  0.06383  -0.01753 220 LEU A CB  
1773 C CG  . LEU A 226 ? 0.21940 0.27436 0.29885 0.08191  0.05713  -0.00943 220 LEU A CG  
1774 C CD1 . LEU A 226 ? 0.25355 0.30073 0.30621 0.06794  0.06461  -0.00090 220 LEU A CD1 
1775 C CD2 . LEU A 226 ? 0.23290 0.26960 0.31310 0.04360  0.04435  -0.00889 220 LEU A CD2 
1776 N N   . SER A 227 ? 0.26232 0.29758 0.33792 0.04359  0.02936  -0.05058 221 SER A N   
1777 C CA  . SER A 227 ? 0.30635 0.30332 0.38927 0.05819  0.03428  -0.05748 221 SER A CA  
1778 C C   . SER A 227 ? 0.29117 0.29544 0.39075 0.07983  0.01293  -0.05004 221 SER A C   
1779 O O   . SER A 227 ? 0.35278 0.29070 0.39774 0.07849  0.02183  -0.05954 221 SER A O   
1780 C CB  . SER A 227 ? 0.31300 0.32481 0.43913 0.06958  0.03223  -0.04327 221 SER A CB  
1781 O OG  . SER A 227 ? 0.30429 0.32281 0.46717 0.04353  0.03128  -0.02533 221 SER A OG  
1782 N N   . ASN A 228 ? 0.22809 0.30750 0.40431 0.08007  0.00436  -0.03018 222 ASN A N   
1783 C CA  . ASN A 228 ? 0.20430 0.31933 0.42204 0.05381  -0.05012 -0.00345 222 ASN A CA  
1784 C C   . ASN A 228 ? 0.23327 0.33069 0.46537 0.05291  -0.06968 0.01483  222 ASN A C   
1785 O O   . ASN A 228 ? 0.29666 0.39322 0.52697 0.06048  -0.05611 0.08230  222 ASN A O   
1786 C CB  . ASN A 228 ? 0.22496 0.32844 0.39285 0.03001  0.00053  -0.02509 222 ASN A CB  
1787 C CG  . ASN A 228 ? 0.25721 0.32507 0.38384 0.02948  0.02831  0.00274  222 ASN A CG  
1788 O OD1 . ASN A 228 ? 0.29444 0.33993 0.38447 0.03019  0.03207  -0.00730 222 ASN A OD1 
1789 N ND2 . ASN A 228 ? 0.25767 0.31136 0.37848 0.02380  0.05786  0.01060  222 ASN A ND2 
1790 N N   . ARG A 229 ? 0.22838 0.31002 0.43860 0.02847  -0.06405 -0.04036 223 ARG A N   
1791 C CA  . ARG A 229 ? 0.25388 0.29172 0.45424 0.00972  -0.00330 -0.05019 223 ARG A CA  
1792 C C   . ARG A 229 ? 0.23724 0.24614 0.41281 0.03284  -0.01873 -0.01061 223 ARG A C   
1793 O O   . ARG A 229 ? 0.23404 0.23766 0.36434 0.01464  -0.03869 -0.01247 223 ARG A O   
1794 C CB  . ARG A 229 ? 0.32789 0.32366 0.50548 0.01590  0.03486  -0.08439 223 ARG A CB  
1795 C CG  . ARG A 229 ? 0.39754 0.37809 0.54677 0.00858  0.02650  -0.06076 223 ARG A CG  
1796 C CD  . ARG A 229 ? 0.42402 0.39249 0.56522 -0.00314 0.04589  -0.05721 223 ARG A CD  
1797 N NE  . ARG A 229 ? 0.44444 0.40551 0.58070 -0.00823 0.05227  -0.05097 223 ARG A NE  
1798 C CZ  . ARG A 229 ? 0.45505 0.41202 0.59710 -0.02910 0.05487  -0.05131 223 ARG A CZ  
1799 N NH1 . ARG A 229 ? 0.44130 0.38982 0.61393 -0.04584 0.05518  -0.07456 223 ARG A NH1 
1800 N NH2 . ARG A 229 ? 0.47575 0.43118 0.60235 -0.02872 0.06638  -0.03440 223 ARG A NH2 
1801 N N   . PRO A 230 ? 0.26287 0.23382 0.39783 0.04139  -0.01901 0.04264  224 PRO A N   
1802 C CA  . PRO A 230 ? 0.23983 0.23275 0.37826 0.04226  -0.03393 0.04362  224 PRO A CA  
1803 C C   . PRO A 230 ? 0.23738 0.22269 0.35501 0.01335  -0.00964 0.00324  224 PRO A C   
1804 O O   . PRO A 230 ? 0.22984 0.24233 0.34228 -0.00052 -0.01740 -0.03169 224 PRO A O   
1805 C CB  . PRO A 230 ? 0.30218 0.25515 0.40020 0.06663  -0.00231 0.07100  224 PRO A CB  
1806 C CG  . PRO A 230 ? 0.34228 0.27879 0.45821 0.05064  0.03937  0.08516  224 PRO A CG  
1807 C CD  . PRO A 230 ? 0.30101 0.27159 0.44722 0.02505  0.01146  0.06775  224 PRO A CD  
1808 N N   . ILE A 231 ? 0.21775 0.22152 0.33996 0.01715  -0.01299 0.01476  225 ILE A N   
1809 C CA  . ILE A 231 ? 0.20636 0.21958 0.33947 0.00578  -0.01041 0.00454  225 ILE A CA  
1810 C C   . ILE A 231 ? 0.21983 0.21043 0.35189 -0.01330 0.00265  -0.00528 225 ILE A C   
1811 O O   . ILE A 231 ? 0.24752 0.23263 0.35260 -0.00766 0.01216  -0.01299 225 ILE A O   
1812 C CB  A ILE A 231 ? 0.22819 0.18817 0.30815 0.00117  0.00965  -0.02272 225 ILE A CB  
1813 C CB  B ILE A 231 ? 0.19273 0.20051 0.34187 0.00330  -0.00927 -0.00486 225 ILE A CB  
1814 C CG1 A ILE A 231 ? 0.26850 0.19278 0.29517 0.01930  0.02026  -0.00262 225 ILE A CG1 
1815 C CG1 B ILE A 231 ? 0.20106 0.20098 0.34713 0.00968  -0.00554 0.01699  225 ILE A CG1 
1816 C CG2 A ILE A 231 ? 0.22430 0.15894 0.28358 -0.00364 0.05127  -0.02101 225 ILE A CG2 
1817 C CG2 B ILE A 231 ? 0.18381 0.18571 0.33641 0.01015  0.00108  -0.00552 225 ILE A CG2 
1818 C CD1 A ILE A 231 ? 0.27650 0.19660 0.28900 0.00172  0.06297  0.01263  225 ILE A CD1 
1819 C CD1 B ILE A 231 ? 0.20771 0.20464 0.35849 -0.00260 0.00826  0.02451  225 ILE A CD1 
1820 N N   . PHE A 232 ? 0.18509 0.19049 0.33379 0.00033  0.00781  0.01903  226 PHE A N   
1821 C CA  . PHE A 232 ? 0.21325 0.19524 0.32527 -0.01102 0.01190  0.01624  226 PHE A CA  
1822 C C   . PHE A 232 ? 0.23911 0.20373 0.38459 -0.00844 -0.00156 0.02328  226 PHE A C   
1823 O O   . PHE A 232 ? 0.24785 0.21485 0.37356 -0.04330 -0.02543 0.02561  226 PHE A O   
1824 C CB  . PHE A 232 ? 0.20331 0.20808 0.26643 0.00231  -0.00659 0.03545  226 PHE A CB  
1825 C CG  . PHE A 232 ? 0.19696 0.20660 0.25567 -0.00088 -0.00557 0.01083  226 PHE A CG  
1826 C CD1 . PHE A 232 ? 0.22635 0.22076 0.23228 -0.00270 0.02489  0.01909  226 PHE A CD1 
1827 C CD2 . PHE A 232 ? 0.15298 0.20903 0.24557 -0.00685 -0.01117 0.00070  226 PHE A CD2 
1828 C CE1 . PHE A 232 ? 0.19732 0.22410 0.22106 -0.01194 0.02762  0.00416  226 PHE A CE1 
1829 C CE2 . PHE A 232 ? 0.17438 0.22174 0.18827 0.02092  -0.01330 0.01964  226 PHE A CE2 
1830 C CZ  . PHE A 232 ? 0.13695 0.23351 0.22015 0.02495  0.00025  0.00043  226 PHE A CZ  
1831 N N   . PRO A 233 ? 0.32315 0.19594 0.44951 -0.01898 -0.01623 0.04414  227 PRO A N   
1832 C CA  . PRO A 233 ? 0.30644 0.20784 0.49304 -0.02679 -0.06935 0.05254  227 PRO A CA  
1833 C C   . PRO A 233 ? 0.33817 0.23607 0.51523 -0.06772 -0.08611 0.05373  227 PRO A C   
1834 O O   . PRO A 233 ? 0.35690 0.24420 0.52277 -0.09946 -0.09089 0.03843  227 PRO A O   
1835 C CB  . PRO A 233 ? 0.34114 0.22077 0.51076 0.00023  -0.02927 0.05338  227 PRO A CB  
1836 C CG  . PRO A 233 ? 0.32906 0.20082 0.49140 -0.03045 -0.04305 0.04084  227 PRO A CG  
1837 C CD  . PRO A 233 ? 0.30577 0.18820 0.48128 -0.00594 -0.02149 0.04858  227 PRO A CD  
1838 N N   . GLY A 234 ? 0.32289 0.25261 0.50223 -0.11872 -0.12799 0.06575  228 GLY A N   
1839 C CA  . GLY A 234 ? 0.33815 0.27695 0.46463 -0.14317 -0.14903 0.08567  228 GLY A CA  
1840 C C   . GLY A 234 ? 0.39957 0.29697 0.49704 -0.15690 -0.18793 0.11680  228 GLY A C   
1841 O O   . GLY A 234 ? 0.39828 0.31161 0.50938 -0.13827 -0.19603 0.15161  228 GLY A O   
1842 N N   . LYS A 235 ? 0.47038 0.30134 0.50100 -0.16797 -0.17038 0.14524  229 LYS A N   
1843 C CA  . LYS A 235 ? 0.54444 0.33404 0.51520 -0.18959 -0.15051 0.10373  229 LYS A CA  
1844 C C   . LYS A 235 ? 0.59981 0.35089 0.47319 -0.21531 -0.11693 0.10208  229 LYS A C   
1845 O O   . LYS A 235 ? 0.67969 0.39310 0.49045 -0.16501 -0.09620 0.13065  229 LYS A O   
1846 C CB  . LYS A 235 ? 0.58742 0.38118 0.59204 -0.13072 -0.08856 0.12192  229 LYS A CB  
1847 C CG  . LYS A 235 ? 0.61034 0.41147 0.62321 -0.10677 -0.05860 0.12357  229 LYS A CG  
1848 C CD  . LYS A 235 ? 0.65366 0.43391 0.65872 -0.09347 -0.01048 0.11554  229 LYS A CD  
1849 C CE  . LYS A 235 ? 0.68889 0.44355 0.67357 -0.07786 0.01249  0.11950  229 LYS A CE  
1850 N NZ  . LYS A 235 ? 0.70444 0.43924 0.68482 -0.07670 0.02373  0.12506  229 LYS A NZ  
1851 N N   . HIS A 236 ? 0.59579 0.38160 0.43922 -0.26926 -0.05833 0.04752  230 HIS A N   
1852 C CA  . HIS A 236 ? 0.60954 0.41257 0.41063 -0.28749 -0.00385 0.03309  230 HIS A CA  
1853 C C   . HIS A 236 ? 0.63467 0.42776 0.43244 -0.28803 0.03430  0.03819  230 HIS A C   
1854 O O   . HIS A 236 ? 0.65295 0.42890 0.38604 -0.30237 -0.00749 0.02871  230 HIS A O   
1855 C CB  . HIS A 236 ? 0.62808 0.45923 0.36736 -0.28424 0.02796  -0.01591 230 HIS A CB  
1856 C CG  . HIS A 236 ? 0.63452 0.49009 0.36592 -0.28617 0.07877  -0.04247 230 HIS A CG  
1857 N ND1 . HIS A 236 ? 0.65691 0.52310 0.35733 -0.27616 0.09973  -0.02220 230 HIS A ND1 
1858 C CD2 . HIS A 236 ? 0.59717 0.49250 0.33616 -0.31843 0.07402  -0.05012 230 HIS A CD2 
1859 C CE1 . HIS A 236 ? 0.63082 0.52163 0.33388 -0.28707 0.12790  -0.03233 230 HIS A CE1 
1860 N NE2 . HIS A 236 ? 0.60725 0.52528 0.34072 -0.30037 0.12060  -0.04221 230 HIS A NE2 
1861 N N   . TYR A 237 ? 0.59417 0.44013 0.44714 -0.21122 0.04941  0.06047  231 TYR A N   
1862 C CA  . TYR A 237 ? 0.49698 0.43535 0.39750 -0.19257 0.02817  0.04748  231 TYR A CA  
1863 C C   . TYR A 237 ? 0.42219 0.44309 0.37011 -0.21597 -0.00234 0.04066  231 TYR A C   
1864 O O   . TYR A 237 ? 0.37482 0.45571 0.35805 -0.20986 0.00920  0.03335  231 TYR A O   
1865 C CB  . TYR A 237 ? 0.49120 0.42414 0.35246 -0.16268 0.07272  0.04080  231 TYR A CB  
1866 C CG  . TYR A 237 ? 0.47549 0.43482 0.32859 -0.14355 0.08880  0.04003  231 TYR A CG  
1867 C CD1 . TYR A 237 ? 0.48347 0.44186 0.34818 -0.12382 0.06201  0.02095  231 TYR A CD1 
1868 C CD2 . TYR A 237 ? 0.48631 0.41910 0.30111 -0.14115 0.08909  0.04131  231 TYR A CD2 
1869 C CE1 . TYR A 237 ? 0.48340 0.45517 0.34473 -0.11957 0.06051  0.03774  231 TYR A CE1 
1870 C CE2 . TYR A 237 ? 0.49554 0.44102 0.30323 -0.14650 0.08081  0.04480  231 TYR A CE2 
1871 C CZ  . TYR A 237 ? 0.47293 0.44726 0.30702 -0.13322 0.06709  0.04299  231 TYR A CZ  
1872 O OH  . TYR A 237 ? 0.46582 0.47374 0.27274 -0.12371 0.04946  0.05135  231 TYR A OH  
1873 N N   . LEU A 238 ? 0.40930 0.46111 0.39033 -0.20435 -0.03781 0.05187  232 LEU A N   
1874 C CA  . LEU A 238 ? 0.37419 0.44094 0.40681 -0.19744 -0.04890 0.02668  232 LEU A CA  
1875 C C   . LEU A 238 ? 0.41325 0.44377 0.44007 -0.17140 0.01405  0.04834  232 LEU A C   
1876 O O   . LEU A 238 ? 0.43083 0.45620 0.48809 -0.14217 0.03693  0.07949  232 LEU A O   
1877 C CB  . LEU A 238 ? 0.37924 0.42854 0.40631 -0.15861 -0.03250 0.04296  232 LEU A CB  
1878 C CG  . LEU A 238 ? 0.36445 0.40909 0.35430 -0.13313 -0.05390 0.02683  232 LEU A CG  
1879 C CD1 . LEU A 238 ? 0.38995 0.42335 0.39093 -0.09761 0.05613  0.06639  232 LEU A CD1 
1880 C CD2 . LEU A 238 ? 0.36547 0.41120 0.34811 -0.08939 -0.05162 0.01771  232 LEU A CD2 
1881 N N   . ASP A 239 ? 0.42505 0.41789 0.44253 -0.16377 0.03669  0.00398  233 ASP A N   
1882 C CA  . ASP A 239 ? 0.39744 0.40326 0.41014 -0.15572 -0.00779 0.03298  233 ASP A CA  
1883 C C   . ASP A 239 ? 0.30940 0.40018 0.35090 -0.12861 -0.04977 0.04917  233 ASP A C   
1884 O O   . ASP A 239 ? 0.27392 0.42974 0.32725 -0.09818 -0.01086 0.06582  233 ASP A O   
1885 C CB  . ASP A 239 ? 0.42459 0.39588 0.42091 -0.13733 -0.07568 0.07428  233 ASP A CB  
1886 C CG  . ASP A 239 ? 0.41548 0.38798 0.46213 -0.14214 -0.12164 0.07209  233 ASP A CG  
1887 O OD1 . ASP A 239 ? 0.39529 0.42110 0.44723 -0.10116 -0.11313 0.06066  233 ASP A OD1 
1888 O OD2 . ASP A 239 ? 0.45964 0.36121 0.50382 -0.16483 -0.12471 0.08248  233 ASP A OD2 
1889 N N   . GLN A 240 ? 0.30372 0.35616 0.35761 -0.16718 -0.06223 0.01866  234 GLN A N   
1890 C CA  . GLN A 240 ? 0.28341 0.34036 0.31519 -0.13765 -0.08062 0.07275  234 GLN A CA  
1891 C C   . GLN A 240 ? 0.26702 0.38383 0.33307 -0.12102 -0.08545 0.09759  234 GLN A C   
1892 O O   . GLN A 240 ? 0.28450 0.41067 0.31162 -0.11141 -0.06930 0.10577  234 GLN A O   
1893 C CB  . GLN A 240 ? 0.29886 0.30102 0.36765 -0.13191 -0.06285 0.05606  234 GLN A CB  
1894 C CG  . GLN A 240 ? 0.26696 0.24581 0.34521 -0.12595 -0.08218 0.07421  234 GLN A CG  
1895 C CD  . GLN A 240 ? 0.25375 0.24019 0.33088 -0.07350 -0.08830 0.10734  234 GLN A CD  
1896 O OE1 . GLN A 240 ? 0.26747 0.25367 0.37597 -0.05323 -0.02713 0.11512  234 GLN A OE1 
1897 N NE2 . GLN A 240 ? 0.28017 0.24297 0.31414 -0.09456 -0.06680 0.06692  234 GLN A NE2 
1898 N N   . LEU A 241 ? 0.24457 0.41166 0.33473 -0.09952 -0.11056 0.08887  235 LEU A N   
1899 C CA  . LEU A 241 ? 0.19231 0.43926 0.36933 -0.08675 -0.10218 0.10399  235 LEU A CA  
1900 C C   . LEU A 241 ? 0.22097 0.45036 0.40724 -0.07311 -0.08353 0.06609  235 LEU A C   
1901 O O   . LEU A 241 ? 0.21895 0.47119 0.38724 -0.05797 -0.06466 0.08024  235 LEU A O   
1902 C CB  . LEU A 241 ? 0.17610 0.44044 0.38513 -0.09457 -0.07110 0.10341  235 LEU A CB  
1903 C CG  . LEU A 241 ? 0.17276 0.43256 0.39505 -0.10923 -0.04308 0.07511  235 LEU A CG  
1904 C CD1 . LEU A 241 ? 0.16793 0.44659 0.40458 -0.10151 -0.04384 0.07243  235 LEU A CD1 
1905 C CD2 . LEU A 241 ? 0.17845 0.44837 0.42093 -0.11287 -0.00371 0.08133  235 LEU A CD2 
1906 N N   . ASN A 242 ? 0.29445 0.42900 0.44020 -0.11116 -0.00734 0.02281  236 ASN A N   
1907 C CA  . ASN A 242 ? 0.33260 0.40363 0.37209 -0.10935 -0.04175 0.02605  236 ASN A CA  
1908 C C   . ASN A 242 ? 0.34059 0.35697 0.32500 -0.12530 -0.08995 0.04962  236 ASN A C   
1909 O O   . ASN A 242 ? 0.35902 0.37527 0.28948 -0.13934 -0.12184 0.04142  236 ASN A O   
1910 C CB  . ASN A 242 ? 0.31504 0.40308 0.37492 -0.10733 -0.05038 -0.01223 236 ASN A CB  
1911 C CG  . ASN A 242 ? 0.30611 0.41714 0.40691 -0.09151 -0.04036 -0.01926 236 ASN A CG  
1912 O OD1 . ASN A 242 ? 0.28130 0.41989 0.38870 -0.10151 -0.01168 -0.05533 236 ASN A OD1 
1913 N ND2 . ASN A 242 ? 0.32289 0.42798 0.44725 -0.06564 -0.07571 0.01213  236 ASN A ND2 
1914 N N   . HIS A 243 ? 0.33035 0.30492 0.38413 -0.11334 -0.05100 0.04390  237 HIS A N   
1915 C CA  . HIS A 243 ? 0.32273 0.26547 0.38182 -0.06818 -0.07018 0.02995  237 HIS A CA  
1916 C C   . HIS A 243 ? 0.28228 0.23572 0.35025 -0.05852 -0.04241 0.01502  237 HIS A C   
1917 O O   . HIS A 243 ? 0.28845 0.21288 0.34204 -0.04205 -0.03565 0.02339  237 HIS A O   
1918 C CB  . HIS A 243 ? 0.33821 0.25450 0.40927 -0.03552 -0.08901 0.01519  237 HIS A CB  
1919 C CG  . HIS A 243 ? 0.36383 0.25714 0.43740 0.03045  -0.05761 0.03026  237 HIS A CG  
1920 N ND1 . HIS A 243 ? 0.42075 0.27249 0.48823 0.04220  -0.04925 0.05473  237 HIS A ND1 
1921 C CD2 . HIS A 243 ? 0.36465 0.23962 0.45203 0.05775  -0.05144 0.03732  237 HIS A CD2 
1922 C CE1 . HIS A 243 ? 0.44340 0.27136 0.51622 0.04124  -0.01433 0.07258  237 HIS A CE1 
1923 N NE2 . HIS A 243 ? 0.39605 0.27819 0.48882 0.04725  -0.05981 0.07201  237 HIS A NE2 
1924 N N   . ILE A 244 ? 0.20434 0.24694 0.31423 -0.03080 -0.01781 0.00929  238 ILE A N   
1925 C CA  . ILE A 244 ? 0.20295 0.26264 0.28152 -0.03251 -0.00969 -0.00262 238 ILE A CA  
1926 C C   . ILE A 244 ? 0.20902 0.27079 0.28998 -0.01617 -0.01407 -0.02104 238 ILE A C   
1927 O O   . ILE A 244 ? 0.24019 0.27910 0.27746 -0.00233 -0.00236 -0.03129 238 ILE A O   
1928 C CB  . ILE A 244 ? 0.21246 0.28046 0.22489 -0.00130 -0.02829 0.00359  238 ILE A CB  
1929 C CG1 . ILE A 244 ? 0.18498 0.29537 0.23593 -0.02182 -0.02105 -0.00680 238 ILE A CG1 
1930 C CG2 . ILE A 244 ? 0.19205 0.29311 0.21952 0.01148  -0.03764 0.02926  238 ILE A CG2 
1931 C CD1 . ILE A 244 ? 0.21920 0.29428 0.24571 0.01356  0.01874  0.00099  238 ILE A CD1 
1932 N N   . LEU A 245 ? 0.19781 0.27138 0.29900 -0.02652 -0.06314 -0.02914 239 LEU A N   
1933 C CA  . LEU A 245 ? 0.21318 0.30323 0.30623 -0.02299 -0.04320 -0.04102 239 LEU A CA  
1934 C C   . LEU A 245 ? 0.25161 0.31369 0.28995 -0.00967 -0.02590 -0.03453 239 LEU A C   
1935 O O   . LEU A 245 ? 0.27655 0.31145 0.23786 0.00771  -0.04019 -0.01213 239 LEU A O   
1936 C CB  . LEU A 245 ? 0.19214 0.30759 0.35484 -0.00161 -0.03696 -0.00809 239 LEU A CB  
1937 C CG  . LEU A 245 ? 0.22745 0.28283 0.35818 0.00351  -0.01795 0.01433  239 LEU A CG  
1938 C CD1 . LEU A 245 ? 0.24249 0.29349 0.36897 -0.02892 -0.03554 -0.00086 239 LEU A CD1 
1939 C CD2 . LEU A 245 ? 0.32453 0.30517 0.36310 0.03855  0.00546  0.03923  239 LEU A CD2 
1940 N N   . GLY A 246 ? 0.25287 0.31509 0.28210 -0.01578 -0.03132 -0.05671 240 GLY A N   
1941 C CA  . GLY A 246 ? 0.23060 0.31960 0.27999 -0.01506 -0.02638 -0.04141 240 GLY A CA  
1942 C C   . GLY A 246 ? 0.24464 0.32521 0.26891 -0.01274 -0.04412 -0.04979 240 GLY A C   
1943 O O   . GLY A 246 ? 0.29836 0.33420 0.27868 -0.01989 0.01534  -0.05120 240 GLY A O   
1944 N N   . ILE A 247 ? 0.22110 0.30273 0.28446 -0.00373 -0.03281 -0.05241 241 ILE A N   
1945 C CA  . ILE A 247 ? 0.23022 0.30054 0.27630 0.00042  -0.02736 -0.06882 241 ILE A CA  
1946 C C   . ILE A 247 ? 0.25036 0.31446 0.23403 0.03032  -0.03562 -0.04733 241 ILE A C   
1947 O O   . ILE A 247 ? 0.25683 0.32366 0.23887 0.02804  -0.04019 -0.04021 241 ILE A O   
1948 C CB  . ILE A 247 ? 0.22013 0.30170 0.31270 -0.00318 -0.05221 -0.05084 241 ILE A CB  
1949 C CG1 . ILE A 247 ? 0.26525 0.33187 0.36421 -0.00533 -0.08022 -0.03341 241 ILE A CG1 
1950 C CG2 . ILE A 247 ? 0.19601 0.30533 0.32859 -0.00076 -0.05292 -0.03211 241 ILE A CG2 
1951 C CD1 . ILE A 247 ? 0.34561 0.34829 0.37303 0.01968  -0.01174 -0.03680 241 ILE A CD1 
1952 N N   . LEU A 248 ? 0.22757 0.30481 0.24618 0.04530  -0.01785 -0.03992 242 LEU A N   
1953 C CA  . LEU A 248 ? 0.25951 0.30145 0.25390 0.03432  0.00526  -0.04355 242 LEU A CA  
1954 C C   . LEU A 248 ? 0.24741 0.31655 0.24882 0.01084  -0.00801 -0.05810 242 LEU A C   
1955 O O   . LEU A 248 ? 0.28315 0.32256 0.24865 0.02743  -0.00038 -0.03732 242 LEU A O   
1956 C CB  A LEU A 248 ? 0.24431 0.27516 0.23718 0.04406  0.02427  -0.06829 242 LEU A CB  
1957 C CB  B LEU A 248 ? 0.26217 0.28118 0.22130 0.02913  0.00485  -0.06253 242 LEU A CB  
1958 C CG  A LEU A 248 ? 0.21030 0.27586 0.22650 0.04168  0.03701  -0.08519 242 LEU A CG  
1959 C CG  B LEU A 248 ? 0.24591 0.29545 0.20846 0.01093  0.00647  -0.07337 242 LEU A CG  
1960 C CD1 A LEU A 248 ? 0.20225 0.26793 0.21491 0.05657  0.06274  -0.07949 242 LEU A CD1 
1961 C CD1 B LEU A 248 ? 0.24925 0.30304 0.21857 0.00381  0.02715  -0.06868 242 LEU A CD1 
1962 C CD2 A LEU A 248 ? 0.21454 0.28241 0.23218 0.03142  0.05072  -0.08872 242 LEU A CD2 
1963 C CD2 B LEU A 248 ? 0.25802 0.30278 0.21771 -0.01222 0.04273  -0.08807 242 LEU A CD2 
1964 N N   . GLY A 249 ? 0.23802 0.32129 0.23158 -0.00429 -0.02032 -0.08296 243 GLY A N   
1965 C CA  . GLY A 249 ? 0.21556 0.32958 0.23534 0.03109  -0.04819 -0.06272 243 GLY A CA  
1966 C C   . GLY A 249 ? 0.22635 0.33317 0.23702 0.02381  -0.01818 -0.03398 243 GLY A C   
1967 O O   . GLY A 249 ? 0.24050 0.38005 0.22280 0.03995  -0.03551 -0.01454 243 GLY A O   
1968 N N   . SER A 250 ? 0.20686 0.28910 0.25110 0.03175  0.00248  -0.00671 244 SER A N   
1969 C CA  . SER A 250 ? 0.24430 0.26016 0.25171 0.03019  -0.00270 -0.01449 244 SER A CA  
1970 C C   . SER A 250 ? 0.25663 0.24747 0.23461 0.02338  -0.00534 0.00381  244 SER A C   
1971 O O   . SER A 250 ? 0.28139 0.24957 0.26532 -0.00147 0.01705  0.00499  244 SER A O   
1972 C CB  . SER A 250 ? 0.27542 0.23689 0.27476 0.01914  0.04211  -0.04290 244 SER A CB  
1973 O OG  . SER A 250 ? 0.27603 0.24253 0.30263 0.01201  0.05095  -0.05290 244 SER A OG  
1974 N N   . PRO A 251 ? 0.23756 0.23549 0.20671 0.03893  -0.03360 0.00883  245 PRO A N   
1975 C CA  . PRO A 251 ? 0.24298 0.24935 0.19948 0.04477  -0.04829 -0.01537 245 PRO A CA  
1976 C C   . PRO A 251 ? 0.23816 0.26937 0.17956 0.02300  -0.03043 -0.02914 245 PRO A C   
1977 O O   . PRO A 251 ? 0.24079 0.28900 0.18426 0.01823  -0.06178 -0.03417 245 PRO A O   
1978 C CB  . PRO A 251 ? 0.29559 0.25719 0.18125 0.03234  -0.02021 -0.00792 245 PRO A CB  
1979 C CG  . PRO A 251 ? 0.34548 0.27433 0.24277 0.03520  0.05828  -0.00466 245 PRO A CG  
1980 C CD  . PRO A 251 ? 0.28799 0.26465 0.21299 0.05845  0.02888  0.02218  245 PRO A CD  
1981 N N   . SER A 252 ? 0.22464 0.27666 0.21419 0.02246  0.00598  -0.02813 246 SER A N   
1982 C CA  . SER A 252 ? 0.21714 0.28333 0.22267 0.01020  -0.04248 -0.01462 246 SER A CA  
1983 C C   . SER A 252 ? 0.21472 0.29124 0.26040 0.01940  -0.01569 -0.01627 246 SER A C   
1984 O O   . SER A 252 ? 0.18692 0.28688 0.22584 0.01611  -0.04044 0.01993  246 SER A O   
1985 C CB  . SER A 252 ? 0.25103 0.27863 0.19311 -0.01590 -0.05072 -0.04767 246 SER A CB  
1986 O OG  . SER A 252 ? 0.26480 0.28494 0.23437 0.02034  -0.01959 -0.03915 246 SER A OG  
1987 N N   . GLN A 253 ? 0.22360 0.31805 0.28123 0.04871  -0.01830 -0.04446 247 GLN A N   
1988 C CA  . GLN A 253 ? 0.20822 0.34944 0.29716 0.06384  -0.05594 -0.03226 247 GLN A CA  
1989 C C   . GLN A 253 ? 0.23076 0.31921 0.28933 0.05147  -0.02315 0.01266  247 GLN A C   
1990 O O   . GLN A 253 ? 0.23557 0.30153 0.31006 0.06616  0.00230  0.03625  247 GLN A O   
1991 C CB  . GLN A 253 ? 0.26365 0.38722 0.32426 0.07248  -0.04481 -0.04612 247 GLN A CB  
1992 C CG  . GLN A 253 ? 0.28184 0.41222 0.35574 0.08878  -0.02943 -0.03953 247 GLN A CG  
1993 C CD  A GLN A 253 ? 0.31706 0.43403 0.37725 0.08255  -0.01401 -0.05063 247 GLN A CD  
1994 C CD  B GLN A 253 ? 0.30681 0.42418 0.38374 0.10687  -0.03639 -0.02197 247 GLN A CD  
1995 O OE1 A GLN A 253 ? 0.32939 0.45525 0.40083 0.09021  -0.01146 -0.05925 247 GLN A OE1 
1996 O OE1 B GLN A 253 ? 0.29502 0.42180 0.39546 0.09867  -0.06548 -0.03861 247 GLN A OE1 
1997 N NE2 A GLN A 253 ? 0.34987 0.43167 0.37488 0.06308  -0.01765 -0.07371 247 GLN A NE2 
1998 N NE2 B GLN A 253 ? 0.32520 0.42544 0.37560 0.11155  -0.05601 0.01784  247 GLN A NE2 
1999 N N   . GLU A 254 ? 0.22644 0.30444 0.26431 0.00416  -0.03821 0.01431  248 GLU A N   
2000 C CA  . GLU A 254 ? 0.23998 0.30325 0.25614 -0.00008 -0.04417 0.02210  248 GLU A CA  
2001 C C   . GLU A 254 ? 0.22372 0.31570 0.26359 0.00903  0.00638  0.01085  248 GLU A C   
2002 O O   . GLU A 254 ? 0.23880 0.34390 0.28742 0.01642  0.03703  -0.00092 248 GLU A O   
2003 C CB  . GLU A 254 ? 0.33576 0.30300 0.30673 0.00648  -0.01821 0.02273  248 GLU A CB  
2004 C CG  . GLU A 254 ? 0.33612 0.29103 0.33840 0.02411  -0.04259 0.04377  248 GLU A CG  
2005 C CD  . GLU A 254 ? 0.33838 0.28609 0.37713 0.01652  -0.04469 0.06719  248 GLU A CD  
2006 O OE1 . GLU A 254 ? 0.34457 0.28515 0.36567 0.02117  -0.03314 0.07114  248 GLU A OE1 
2007 O OE2 . GLU A 254 ? 0.32387 0.28105 0.41756 0.00867  -0.04749 0.09863  248 GLU A OE2 
2008 N N   . ASP A 255 ? 0.20503 0.32023 0.22861 0.04125  -0.00215 0.03293  249 ASP A N   
2009 C CA  . ASP A 255 ? 0.20178 0.33904 0.22615 0.04135  0.01218  -0.00995 249 ASP A CA  
2010 C C   . ASP A 255 ? 0.22729 0.33912 0.22861 0.00376  0.02307  -0.00305 249 ASP A C   
2011 O O   . ASP A 255 ? 0.25665 0.34649 0.19667 -0.01945 0.02049  0.01700  249 ASP A O   
2012 C CB  . ASP A 255 ? 0.15344 0.32346 0.21796 0.04352  -0.01157 -0.02920 249 ASP A CB  
2013 C CG  . ASP A 255 ? 0.20811 0.31245 0.21140 0.02807  -0.01577 -0.04623 249 ASP A CG  
2014 O OD1 . ASP A 255 ? 0.27188 0.31528 0.24503 0.01532  0.00103  0.00599  249 ASP A OD1 
2015 O OD2 . ASP A 255 ? 0.21190 0.31227 0.25288 0.04135  0.01697  -0.06321 249 ASP A OD2 
2016 N N   . LEU A 256 ? 0.21920 0.33578 0.24199 0.03612  -0.01892 0.00668  250 LEU A N   
2017 C CA  . LEU A 256 ? 0.25203 0.36224 0.23633 0.02141  -0.01893 0.00081  250 LEU A CA  
2018 C C   . LEU A 256 ? 0.26423 0.40519 0.30440 -0.01777 -0.00152 0.02043  250 LEU A C   
2019 O O   . LEU A 256 ? 0.28437 0.41831 0.29637 -0.02967 0.02457  0.00627  250 LEU A O   
2020 C CB  . LEU A 256 ? 0.35144 0.37937 0.26236 0.01983  -0.00563 0.01677  250 LEU A CB  
2021 C CG  . LEU A 256 ? 0.41680 0.40439 0.27062 0.03256  -0.01879 -0.00936 250 LEU A CG  
2022 C CD1 . LEU A 256 ? 0.43926 0.40776 0.30627 0.00773  -0.03989 -0.04413 250 LEU A CD1 
2023 C CD2 . LEU A 256 ? 0.47819 0.42258 0.31548 0.03369  0.01746  -0.01018 250 LEU A CD2 
2024 N N   . ASN A 257 ? 0.23704 0.41784 0.33910 -0.00175 -0.00571 0.04130  251 ASN A N   
2025 C CA  . ASN A 257 ? 0.22736 0.45524 0.37180 0.03394  0.01603  0.03965  251 ASN A CA  
2026 C C   . ASN A 257 ? 0.22371 0.45387 0.38028 0.04385  0.03226  0.00745  251 ASN A C   
2027 O O   . ASN A 257 ? 0.24288 0.48385 0.41509 0.06106  0.10616  -0.02379 251 ASN A O   
2028 C CB  . ASN A 257 ? 0.26800 0.48641 0.38062 0.06038  0.00463  0.04790  251 ASN A CB  
2029 C CG  . ASN A 257 ? 0.29645 0.52062 0.40926 0.08080  0.02688  0.03406  251 ASN A CG  
2030 O OD1 . ASN A 257 ? 0.32006 0.56057 0.43085 0.03991  0.03097  0.00323  251 ASN A OD1 
2031 N ND2 . ASN A 257 ? 0.28269 0.52556 0.39353 0.14397  0.00718  0.04035  251 ASN A ND2 
2032 N N   . CME A 258 ? 0.22012 0.41440 0.37903 0.02007  0.02901  0.01191  252 CME A N   
2033 C CA  . CME A 258 ? 0.24518 0.40168 0.36372 0.01412  0.04779  -0.00291 252 CME A CA  
2034 C CB  . CME A 258 ? 0.27746 0.38495 0.40704 0.01777  0.03932  -0.02838 252 CME A CB  
2035 S SG  . CME A 258 ? 0.34001 0.39285 0.47602 0.01361  0.07923  -0.07698 252 CME A SG  
2036 S SD  . CME A 258 ? 0.39365 0.40244 0.48107 0.02314  0.02122  -0.06186 252 CME A SD  
2037 C CE  . CME A 258 ? 0.44664 0.43499 0.50480 0.04305  -0.01097 -0.03200 252 CME A CE  
2038 C CZ  . CME A 258 ? 0.46456 0.43989 0.51877 0.06057  -0.02474 -0.01071 252 CME A CZ  
2039 O OH  . CME A 258 ? 0.48077 0.43835 0.52075 0.05718  -0.02641 -0.01298 252 CME A OH  
2040 C C   . CME A 258 ? 0.26012 0.41870 0.33987 -0.01153 0.06305  -0.01883 252 CME A C   
2041 O O   . CME A 258 ? 0.31270 0.44133 0.33709 -0.02412 0.00147  -0.05976 252 CME A O   
2042 N N   . ILE A 259 ? 0.21010 0.41399 0.32992 -0.02766 0.06700  0.01376  253 ILE A N   
2043 C CA  . ILE A 259 ? 0.18713 0.40310 0.32695 -0.01298 0.05067  0.02727  253 ILE A CA  
2044 C C   . ILE A 259 ? 0.17008 0.42694 0.32082 -0.00815 0.05546  0.00100  253 ILE A C   
2045 O O   . ILE A 259 ? 0.18509 0.47021 0.31980 -0.00841 0.06935  -0.00733 253 ILE A O   
2046 C CB  . ILE A 259 ? 0.20556 0.37636 0.32578 -0.00908 0.08365  0.02541  253 ILE A CB  
2047 C CG1 . ILE A 259 ? 0.19667 0.33572 0.35505 0.00540  0.10787  0.02579  253 ILE A CG1 
2048 C CG2 . ILE A 259 ? 0.20053 0.37669 0.30718 -0.05896 0.06019  0.03943  253 ILE A CG2 
2049 C CD1 . ILE A 259 ? 0.23117 0.32667 0.38202 0.02714  0.12391  -0.00556 253 ILE A CD1 
2050 N N   . ILE A 260 ? 0.18589 0.42007 0.31039 -0.00047 0.07134  0.01772  254 ILE A N   
2051 C CA  A ILE A 260 ? 0.22468 0.41092 0.32664 0.02744  0.07344  0.00979  254 ILE A CA  
2052 C CA  B ILE A 260 ? 0.21740 0.40787 0.34495 0.00020  0.10233  0.01489  254 ILE A CA  
2053 C C   . ILE A 260 ? 0.23520 0.39352 0.32659 0.04064  0.05819  -0.00541 254 ILE A C   
2054 O O   . ILE A 260 ? 0.21141 0.39591 0.36778 0.05656  0.06303  0.01332  254 ILE A O   
2055 C CB  A ILE A 260 ? 0.28918 0.41664 0.34804 0.04584  0.07370  -0.00952 254 ILE A CB  
2056 C CB  B ILE A 260 ? 0.26325 0.40907 0.39297 -0.03299 0.14732  0.00664  254 ILE A CB  
2057 C CG1 A ILE A 260 ? 0.34235 0.42466 0.37486 0.06362  0.10024  -0.02515 254 ILE A CG1 
2058 C CG1 B ILE A 260 ? 0.31788 0.41222 0.41085 -0.04974 0.15681  0.00332  254 ILE A CG1 
2059 C CG2 A ILE A 260 ? 0.32381 0.42006 0.34030 0.05397  0.05269  -0.01198 254 ILE A CG2 
2060 C CG2 B ILE A 260 ? 0.27372 0.41449 0.42560 -0.03207 0.17623  -0.00442 254 ILE A CG2 
2061 C CD1 A ILE A 260 ? 0.36502 0.42146 0.37769 0.07108  0.08914  -0.02862 254 ILE A CD1 
2062 C CD1 B ILE A 260 ? 0.34997 0.41358 0.41306 -0.06534 0.15450  -0.00844 254 ILE A CD1 
2063 N N   . ASN A 261 ? 0.28141 0.37019 0.28626 0.06310  0.05374  -0.01364 255 ASN A N   
2064 C CA  . ASN A 261 ? 0.31001 0.35051 0.21481 0.03170  0.00943  -0.04232 255 ASN A CA  
2065 C C   . ASN A 261 ? 0.28360 0.36530 0.22765 0.03854  0.02184  -0.04462 255 ASN A C   
2066 O O   . ASN A 261 ? 0.28924 0.36569 0.24459 0.03344  0.02760  -0.05697 255 ASN A O   
2067 C CB  . ASN A 261 ? 0.37787 0.33809 0.21840 -0.01135 -0.05085 -0.01845 255 ASN A CB  
2068 C CG  . ASN A 261 ? 0.44556 0.35326 0.25769 -0.02840 -0.06035 -0.01495 255 ASN A CG  
2069 O OD1 . ASN A 261 ? 0.45954 0.35278 0.31006 -0.05376 -0.07726 -0.00941 255 ASN A OD1 
2070 N ND2 . ASN A 261 ? 0.45638 0.37531 0.26562 -0.02973 -0.09444 -0.00490 255 ASN A ND2 
2071 N N   . LEU A 262 ? 0.24479 0.38527 0.23544 0.04305  0.04737  -0.05171 256 LEU A N   
2072 C CA  . LEU A 262 ? 0.19455 0.42379 0.26897 0.02161  0.02778  -0.02989 256 LEU A CA  
2073 C C   . LEU A 262 ? 0.15805 0.44675 0.24421 -0.00402 0.01614  -0.03161 256 LEU A C   
2074 O O   . LEU A 262 ? 0.17760 0.46895 0.21672 -0.00013 0.01828  -0.04580 256 LEU A O   
2075 C CB  A LEU A 262 ? 0.23329 0.42394 0.32820 0.03854  0.05568  0.00086  256 LEU A CB  
2076 C CB  B LEU A 262 ? 0.19097 0.43785 0.27527 0.04607  0.01948  -0.01313 256 LEU A CB  
2077 C CG  A LEU A 262 ? 0.24347 0.39768 0.35777 0.07196  0.09247  -0.00349 256 LEU A CG  
2078 C CG  B LEU A 262 ? 0.17086 0.43909 0.26758 0.07918  0.01730  -0.01270 256 LEU A CG  
2079 C CD1 A LEU A 262 ? 0.24015 0.39995 0.37488 0.08140  0.08722  -0.01950 256 LEU A CD1 
2080 C CD1 B LEU A 262 ? 0.15099 0.43075 0.24731 0.09887  0.00164  -0.01870 256 LEU A CD1 
2081 C CD2 A LEU A 262 ? 0.27568 0.37982 0.36385 0.08664  0.09049  0.00235  256 LEU A CD2 
2082 C CD2 B LEU A 262 ? 0.18255 0.44483 0.27304 0.09562  0.02440  -0.00357 256 LEU A CD2 
2083 N N   . LYS A 263 ? 0.15484 0.44355 0.26052 0.00893  0.01567  -0.00814 257 LYS A N   
2084 C CA  . LYS A 263 ? 0.21219 0.42319 0.26133 -0.02579 0.05928  -0.00452 257 LYS A CA  
2085 C C   . LYS A 263 ? 0.16551 0.37956 0.24930 -0.01756 0.01172  0.00615  257 LYS A C   
2086 O O   . LYS A 263 ? 0.18306 0.38412 0.26853 -0.00989 0.01843  0.00833  257 LYS A O   
2087 C CB  . LYS A 263 ? 0.27713 0.44544 0.26130 -0.07202 0.05747  -0.02212 257 LYS A CB  
2088 C CG  . LYS A 263 ? 0.30673 0.47300 0.26416 -0.06380 0.05518  -0.00860 257 LYS A CG  
2089 C CD  . LYS A 263 ? 0.35629 0.47333 0.27102 -0.06786 0.05923  0.01470  257 LYS A CD  
2090 C CE  . LYS A 263 ? 0.39838 0.47311 0.29863 -0.06863 0.06851  0.00226  257 LYS A CE  
2091 N NZ  . LYS A 263 ? 0.41375 0.47201 0.32632 -0.06092 0.06368  0.00537  257 LYS A NZ  
2092 N N   . ALA A 264 ? 0.15089 0.33883 0.23500 -0.04489 -0.00118 -0.00821 258 ALA A N   
2093 C CA  . ALA A 264 ? 0.20013 0.30058 0.22385 -0.04167 0.01139  0.00803  258 ALA A CA  
2094 C C   . ALA A 264 ? 0.20715 0.28955 0.20613 -0.00222 0.00289  0.02322  258 ALA A C   
2095 O O   . ALA A 264 ? 0.21203 0.26160 0.20416 -0.00884 -0.00004 0.01611  258 ALA A O   
2096 C CB  . ALA A 264 ? 0.24244 0.30009 0.23089 -0.04077 -0.02259 0.00787  258 ALA A CB  
2097 N N   . ARG A 265 ? 0.19318 0.28155 0.17905 0.02146  0.01369  0.03863  259 ARG A N   
2098 C CA  . ARG A 265 ? 0.20277 0.27359 0.18818 0.08103  0.01621  0.02114  259 ARG A CA  
2099 C C   . ARG A 265 ? 0.20544 0.25715 0.20338 0.03773  0.04423  -0.00036 259 ARG A C   
2100 O O   . ARG A 265 ? 0.21800 0.22828 0.22421 0.05164  0.00623  -0.00691 259 ARG A O   
2101 C CB  . ARG A 265 ? 0.28892 0.27960 0.17399 0.12148  0.02740  -0.00440 259 ARG A CB  
2102 C CG  . ARG A 265 ? 0.31664 0.28692 0.17422 0.11299  -0.01213 -0.00593 259 ARG A CG  
2103 C CD  . ARG A 265 ? 0.32448 0.30348 0.22270 0.10062  -0.00643 -0.02660 259 ARG A CD  
2104 N NE  . ARG A 265 ? 0.29690 0.32652 0.23806 0.06525  -0.01333 -0.01789 259 ARG A NE  
2105 C CZ  . ARG A 265 ? 0.28345 0.33955 0.28311 -0.00089 0.01159  -0.00759 259 ARG A CZ  
2106 N NH1 . ARG A 265 ? 0.31734 0.34875 0.32496 -0.01234 0.04412  -0.01335 259 ARG A NH1 
2107 N NH2 . ARG A 265 ? 0.24012 0.35172 0.29517 -0.05868 -0.01393 -0.00497 259 ARG A NH2 
2108 N N   . ASN A 266 ? 0.20761 0.25901 0.19769 0.02700  0.02033  -0.00993 260 ASN A N   
2109 C CA  . ASN A 266 ? 0.16532 0.25531 0.20607 0.03292  0.00138  -0.00319 260 ASN A CA  
2110 C C   . ASN A 266 ? 0.17442 0.23816 0.21644 0.02586  0.00662  -0.00005 260 ASN A C   
2111 O O   . ASN A 266 ? 0.18272 0.24167 0.23689 0.03051  0.01432  -0.03875 260 ASN A O   
2112 C CB  . ASN A 266 ? 0.15517 0.29742 0.22392 0.06170  0.02090  0.01776  260 ASN A CB  
2113 C CG  . ASN A 266 ? 0.17375 0.29586 0.25330 0.04377  0.03859  0.02093  260 ASN A CG  
2114 O OD1 . ASN A 266 ? 0.20466 0.34250 0.26884 0.04419  0.04473  0.00932  260 ASN A OD1 
2115 N ND2 . ASN A 266 ? 0.16358 0.27268 0.29501 0.07545  0.07201  -0.03523 260 ASN A ND2 
2116 N N   . TYR A 267 ? 0.15189 0.24101 0.23512 0.04092  -0.00802 0.02106  261 TYR A N   
2117 C CA  . TYR A 267 ? 0.17215 0.24892 0.21996 0.05893  0.00649  0.01638  261 TYR A CA  
2118 C C   . TYR A 267 ? 0.17566 0.23693 0.20797 0.05645  0.04077  0.00586  261 TYR A C   
2119 O O   . TYR A 267 ? 0.18486 0.23358 0.18794 0.07526  0.02753  -0.02426 261 TYR A O   
2120 C CB  . TYR A 267 ? 0.16891 0.24830 0.18999 0.04376  -0.03274 0.00757  261 TYR A CB  
2121 C CG  . TYR A 267 ? 0.22227 0.24355 0.18568 0.04164  0.00166  -0.01232 261 TYR A CG  
2122 C CD1 . TYR A 267 ? 0.25316 0.23365 0.21859 0.07332  0.00152  0.00060  261 TYR A CD1 
2123 C CD2 . TYR A 267 ? 0.23669 0.25385 0.19695 0.03000  0.02420  -0.01214 261 TYR A CD2 
2124 C CE1 . TYR A 267 ? 0.20667 0.24973 0.24900 0.07530  0.02559  0.01608  261 TYR A CE1 
2125 C CE2 . TYR A 267 ? 0.21969 0.24017 0.25046 0.03076  0.01577  -0.01501 261 TYR A CE2 
2126 C CZ  . TYR A 267 ? 0.21390 0.23862 0.25900 0.06448  0.01091  0.01295  261 TYR A CZ  
2127 O OH  . TYR A 267 ? 0.24024 0.23980 0.28456 0.07221  0.02773  0.00911  261 TYR A OH  
2128 N N   . LEU A 268 ? 0.17080 0.23108 0.18818 0.04079  0.03356  0.01782  262 LEU A N   
2129 C CA  . LEU A 268 ? 0.18061 0.21769 0.21521 0.02416  0.05158  -0.00758 262 LEU A CA  
2130 C C   . LEU A 268 ? 0.14733 0.21470 0.20006 0.04239  0.03415  -0.02018 262 LEU A C   
2131 O O   . LEU A 268 ? 0.20571 0.23833 0.20346 0.04329  0.06746  -0.01005 262 LEU A O   
2132 C CB  . LEU A 268 ? 0.21113 0.21201 0.22622 0.02191  0.02688  -0.01028 262 LEU A CB  
2133 C CG  . LEU A 268 ? 0.18983 0.25681 0.26895 0.01027  0.04032  -0.03881 262 LEU A CG  
2134 C CD1 . LEU A 268 ? 0.22817 0.24321 0.26497 0.02981  0.00865  -0.04975 262 LEU A CD1 
2135 C CD2 . LEU A 268 ? 0.19396 0.31087 0.29263 0.01709  0.05238  -0.00209 262 LEU A CD2 
2136 N N   . LEU A 269 ? 0.15233 0.21054 0.22597 0.03808  -0.00846 0.00909  263 LEU A N   
2137 C CA  . LEU A 269 ? 0.17981 0.19445 0.26628 0.05386  -0.03045 -0.01602 263 LEU A CA  
2138 C C   . LEU A 269 ? 0.22858 0.21200 0.26646 0.04032  0.01264  -0.03829 263 LEU A C   
2139 O O   . LEU A 269 ? 0.25920 0.24198 0.25427 0.00512  0.01067  -0.03242 263 LEU A O   
2140 C CB  . LEU A 269 ? 0.18837 0.19099 0.27608 0.07635  -0.00206 0.01856  263 LEU A CB  
2141 C CG  . LEU A 269 ? 0.21105 0.21649 0.25082 0.07684  0.03438  0.03243  263 LEU A CG  
2142 C CD1 . LEU A 269 ? 0.24332 0.24955 0.31414 0.05981  0.07159  0.00390  263 LEU A CD1 
2143 C CD2 . LEU A 269 ? 0.24259 0.23972 0.23426 0.04055  0.03405  0.04712  263 LEU A CD2 
2144 N N   . SER A 270 ? 0.16555 0.21387 0.28189 0.03599  -0.00555 -0.00576 264 SER A N   
2145 C CA  . SER A 270 ? 0.20701 0.21188 0.27225 0.02415  0.01107  -0.00184 264 SER A CA  
2146 C C   . SER A 270 ? 0.22294 0.22985 0.23157 -0.01289 -0.00389 -0.02342 264 SER A C   
2147 O O   . SER A 270 ? 0.27350 0.22090 0.28462 -0.02152 0.04085  -0.04712 264 SER A O   
2148 C CB  . SER A 270 ? 0.22540 0.23897 0.28822 0.02285  0.04485  0.00348  264 SER A CB  
2149 O OG  . SER A 270 ? 0.25915 0.23225 0.31394 0.05335  0.07128  0.02821  264 SER A OG  
2150 N N   . LEU A 271 ? 0.19471 0.23082 0.24047 0.00654  -0.00092 -0.00820 265 LEU A N   
2151 C CA  . LEU A 271 ? 0.22496 0.23184 0.20255 0.03660  -0.01041 -0.02052 265 LEU A CA  
2152 C C   . LEU A 271 ? 0.25775 0.20798 0.20686 0.04943  -0.03437 -0.00923 265 LEU A C   
2153 O O   . LEU A 271 ? 0.28141 0.22069 0.24064 0.05187  -0.02468 0.02219  265 LEU A O   
2154 C CB  . LEU A 271 ? 0.18828 0.24792 0.14331 0.04083  -0.02406 -0.03805 265 LEU A CB  
2155 C CG  . LEU A 271 ? 0.22675 0.23505 0.17090 0.01200  -0.03380 -0.02045 265 LEU A CG  
2156 C CD1 . LEU A 271 ? 0.22762 0.25732 0.20158 0.00997  0.00060  -0.02942 265 LEU A CD1 
2157 C CD2 . LEU A 271 ? 0.28768 0.23119 0.23105 0.00117  0.00060  -0.01001 265 LEU A CD2 
2158 N N   . PRO A 272 ? 0.31692 0.20927 0.18218 0.05646  -0.00857 -0.02563 266 PRO A N   
2159 C CA  . PRO A 272 ? 0.33170 0.21096 0.17580 0.01775  0.02601  -0.00560 266 PRO A CA  
2160 C C   . PRO A 272 ? 0.32413 0.24926 0.16379 -0.01012 0.02432  0.01625  266 PRO A C   
2161 O O   . PRO A 272 ? 0.33533 0.27223 0.21035 -0.02810 0.06400  0.03800  266 PRO A O   
2162 C CB  . PRO A 272 ? 0.38531 0.22408 0.20603 0.05638  0.04473  0.00455  266 PRO A CB  
2163 C CG  . PRO A 272 ? 0.44086 0.23721 0.20670 0.07472  0.08222  -0.02995 266 PRO A CG  
2164 C CD  . PRO A 272 ? 0.37001 0.21604 0.18055 0.08755  0.03708  -0.03490 266 PRO A CD  
2165 N N   . HIS A 273 ? 0.32203 0.27143 0.18963 -0.01612 0.05769  0.02436  267 HIS A N   
2166 C CA  . HIS A 273 ? 0.32473 0.29338 0.19068 -0.01089 0.03634  0.03576  267 HIS A CA  
2167 C C   . HIS A 273 ? 0.28107 0.30723 0.22648 -0.01101 0.05573  -0.03752 267 HIS A C   
2168 O O   . HIS A 273 ? 0.32283 0.31704 0.26395 -0.03087 0.06682  -0.06451 267 HIS A O   
2169 C CB  . HIS A 273 ? 0.40048 0.30424 0.20810 -0.05250 0.05232  0.04988  267 HIS A CB  
2170 C CG  . HIS A 273 ? 0.43881 0.30352 0.25873 -0.06919 0.06132  0.05946  267 HIS A CG  
2171 N ND1 . HIS A 273 ? 0.41071 0.28383 0.25401 -0.07616 0.03129  0.06350  267 HIS A ND1 
2172 C CD2 . HIS A 273 ? 0.48759 0.31112 0.29183 -0.11173 0.13226  0.03516  267 HIS A CD2 
2173 C CE1 . HIS A 273 ? 0.43885 0.28769 0.27951 -0.09280 0.08498  0.05958  267 HIS A CE1 
2174 N NE2 . HIS A 273 ? 0.47488 0.30142 0.30398 -0.11586 0.11138  0.04674  267 HIS A NE2 
2175 N N   . LYS A 274 ? 0.23485 0.31746 0.23748 -0.01291 0.04377  -0.05976 268 LYS A N   
2176 C CA  . LYS A 274 ? 0.25243 0.33647 0.24175 -0.00682 0.03594  -0.06106 268 LYS A CA  
2177 C C   . LYS A 274 ? 0.26983 0.38490 0.25561 -0.02590 0.07962  -0.07461 268 LYS A C   
2178 O O   . LYS A 274 ? 0.25682 0.38334 0.24109 -0.01634 0.04579  -0.03320 268 LYS A O   
2179 C CB  . LYS A 274 ? 0.30734 0.32372 0.29275 -0.00175 0.01251  -0.01663 268 LYS A CB  
2180 C CG  . LYS A 274 ? 0.39027 0.33122 0.34470 -0.02257 0.03796  -0.00404 268 LYS A CG  
2181 C CD  . LYS A 274 ? 0.39563 0.32593 0.39920 -0.06176 0.02936  0.02984  268 LYS A CD  
2182 C CE  . LYS A 274 ? 0.42001 0.32490 0.43000 -0.07816 -0.00270 0.04384  268 LYS A CE  
2183 N NZ  . LYS A 274 ? 0.41777 0.32031 0.43960 -0.09317 -0.03991 0.09342  268 LYS A NZ  
2184 N N   . ASN A 275 ? 0.32198 0.42369 0.28498 -0.05913 0.10513  -0.09767 269 ASN A N   
2185 C CA  . ASN A 275 ? 0.32083 0.45129 0.27620 -0.05783 0.08986  -0.09318 269 ASN A CA  
2186 C C   . ASN A 275 ? 0.27573 0.43061 0.30989 -0.04066 0.02911  -0.06817 269 ASN A C   
2187 O O   . ASN A 275 ? 0.31767 0.43145 0.37177 -0.02846 0.08175  -0.07749 269 ASN A O   
2188 C CB  . ASN A 275 ? 0.37949 0.50766 0.27328 -0.08039 0.10861  -0.12275 269 ASN A CB  
2189 C CG  . ASN A 275 ? 0.40590 0.53943 0.26967 -0.04591 0.09720  -0.08675 269 ASN A CG  
2190 O OD1 . ASN A 275 ? 0.43259 0.53880 0.28563 -0.05506 0.06844  -0.06902 269 ASN A OD1 
2191 N ND2 . ASN A 275 ? 0.41908 0.56283 0.31432 -0.01396 0.15049  -0.07432 269 ASN A ND2 
2192 N N   . LYS A 276 ? 0.24779 0.41261 0.31072 -0.03827 -0.02004 -0.04557 270 LYS A N   
2193 C CA  . LYS A 276 ? 0.21460 0.38545 0.26850 -0.03441 -0.07843 -0.04548 270 LYS A CA  
2194 C C   . LYS A 276 ? 0.24328 0.39974 0.26033 0.01211  -0.00798 -0.04324 270 LYS A C   
2195 O O   . LYS A 276 ? 0.27305 0.46400 0.26691 0.03021  0.03102  -0.01978 270 LYS A O   
2196 C CB  . LYS A 276 ? 0.27340 0.38080 0.32222 -0.04128 -0.07540 -0.03237 270 LYS A CB  
2197 C CG  . LYS A 276 ? 0.30691 0.38357 0.42246 -0.05458 -0.04956 -0.05085 270 LYS A CG  
2198 C CD  . LYS A 276 ? 0.38739 0.39570 0.47551 -0.06939 -0.03003 -0.08046 270 LYS A CD  
2199 C CE  . LYS A 276 ? 0.42620 0.40632 0.49768 -0.04802 -0.03031 -0.09948 270 LYS A CE  
2200 N NZ  . LYS A 276 ? 0.43542 0.41371 0.51476 -0.04081 -0.03322 -0.10670 270 LYS A NZ  
2201 N N   . VAL A 277 ? 0.22266 0.38864 0.27211 0.02420  0.00390  -0.03295 271 VAL A N   
2202 C CA  . VAL A 277 ? 0.21545 0.39703 0.26428 0.04189  -0.01179 0.00508  271 VAL A CA  
2203 C C   . VAL A 277 ? 0.22886 0.39688 0.22821 0.00885  -0.01607 -0.00074 271 VAL A C   
2204 O O   . VAL A 277 ? 0.24189 0.39330 0.23506 0.01895  0.01886  0.00284  271 VAL A O   
2205 C CB  . VAL A 277 ? 0.24261 0.40730 0.30768 0.03565  0.00232  -0.00165 271 VAL A CB  
2206 C CG1 . VAL A 277 ? 0.25232 0.41472 0.35424 0.03878  0.04970  -0.00027 271 VAL A CG1 
2207 C CG2 . VAL A 277 ? 0.28050 0.41296 0.33510 0.02862  0.02586  -0.03574 271 VAL A CG2 
2208 N N   . PRO A 278 ? 0.27405 0.41811 0.24219 -0.04232 0.02105  -0.02998 272 PRO A N   
2209 C CA  . PRO A 278 ? 0.27412 0.41776 0.23543 -0.05114 0.02398  -0.04599 272 PRO A CA  
2210 C C   . PRO A 278 ? 0.25754 0.38773 0.23554 -0.05259 0.02153  -0.05960 272 PRO A C   
2211 O O   . PRO A 278 ? 0.26348 0.37819 0.26779 -0.03627 0.04141  -0.08480 272 PRO A O   
2212 C CB  . PRO A 278 ? 0.28631 0.43846 0.23093 -0.07232 0.01951  -0.04143 272 PRO A CB  
2213 C CG  . PRO A 278 ? 0.31437 0.44322 0.25243 -0.11344 0.03391  -0.05688 272 PRO A CG  
2214 C CD  . PRO A 278 ? 0.31249 0.43462 0.21824 -0.07852 0.03100  -0.03404 272 PRO A CD  
2215 N N   . TRP A 279 ? 0.24149 0.36462 0.21343 -0.04160 -0.00405 -0.05412 273 TRP A N   
2216 C CA  . TRP A 279 ? 0.22442 0.35998 0.23381 -0.04339 -0.00100 -0.08870 273 TRP A CA  
2217 C C   . TRP A 279 ? 0.28090 0.39177 0.24363 -0.01461 0.03507  -0.07923 273 TRP A C   
2218 O O   . TRP A 279 ? 0.28090 0.40194 0.25242 0.01573  0.01402  -0.10408 273 TRP A O   
2219 C CB  . TRP A 279 ? 0.23263 0.34513 0.24298 -0.03380 0.04853  -0.08553 273 TRP A CB  
2220 C CG  . TRP A 279 ? 0.20482 0.32365 0.24067 -0.02664 0.03810  -0.07216 273 TRP A CG  
2221 C CD1 . TRP A 279 ? 0.22075 0.31820 0.25414 -0.00731 0.04958  -0.06000 273 TRP A CD1 
2222 C CD2 . TRP A 279 ? 0.23180 0.32298 0.23085 -0.02787 0.02818  -0.05342 273 TRP A CD2 
2223 N NE1 . TRP A 279 ? 0.25358 0.32915 0.26883 0.00975  0.05058  -0.03317 273 TRP A NE1 
2224 C CE2 . TRP A 279 ? 0.25438 0.31335 0.23734 -0.01377 0.04012  -0.04536 273 TRP A CE2 
2225 C CE3 . TRP A 279 ? 0.26922 0.34339 0.24646 -0.03855 0.04631  -0.08181 273 TRP A CE3 
2226 C CZ2 . TRP A 279 ? 0.24969 0.32406 0.25492 -0.04145 0.01487  -0.08283 273 TRP A CZ2 
2227 C CZ3 . TRP A 279 ? 0.28126 0.36159 0.26536 -0.02758 0.04740  -0.07812 273 TRP A CZ3 
2228 C CH2 . TRP A 279 ? 0.25602 0.35115 0.25543 -0.03281 0.01809  -0.07941 273 TRP A CH2 
2229 N N   . ASN A 280 ? 0.31779 0.43083 0.25332 -0.02507 0.05329  -0.08403 274 ASN A N   
2230 C CA  . ASN A 280 ? 0.33647 0.44630 0.28156 -0.01898 0.06004  -0.05703 274 ASN A CA  
2231 C C   . ASN A 280 ? 0.30403 0.45351 0.31721 -0.00673 0.06169  -0.11227 274 ASN A C   
2232 O O   . ASN A 280 ? 0.25313 0.46000 0.37980 -0.00085 0.06966  -0.13840 274 ASN A O   
2233 C CB  . ASN A 280 ? 0.42635 0.47107 0.28565 -0.04327 0.06408  -0.01384 274 ASN A CB  
2234 C CG  . ASN A 280 ? 0.49005 0.47892 0.27108 -0.03607 0.08520  0.01561  274 ASN A CG  
2235 O OD1 . ASN A 280 ? 0.50418 0.46622 0.24724 -0.05101 0.07770  0.01014  274 ASN A OD1 
2236 N ND2 . ASN A 280 ? 0.53656 0.49349 0.25795 -0.03149 0.07267  0.04960  274 ASN A ND2 
2237 N N   . ARG A 281 ? 0.28205 0.43510 0.31740 0.01062  0.01682  -0.12092 275 ARG A N   
2238 C CA  . ARG A 281 ? 0.26027 0.44767 0.40469 0.02882  0.00376  -0.13670 275 ARG A CA  
2239 C C   . ARG A 281 ? 0.25120 0.42317 0.41745 0.01489  0.00195  -0.14403 275 ARG A C   
2240 O O   . ARG A 281 ? 0.34048 0.43446 0.45401 0.00312  0.03290  -0.14264 275 ARG A O   
2241 C CB  . ARG A 281 ? 0.26028 0.46018 0.43566 0.03647  0.00236  -0.16989 275 ARG A CB  
2242 C CG  . ARG A 281 ? 0.29643 0.49252 0.48663 0.06911  0.02515  -0.16666 275 ARG A CG  
2243 C CD  . ARG A 281 ? 0.35817 0.52183 0.51375 0.07447  0.02132  -0.15810 275 ARG A CD  
2244 N NE  . ARG A 281 ? 0.39987 0.54607 0.53294 0.07655  -0.00056 -0.14745 275 ARG A NE  
2245 C CZ  . ARG A 281 ? 0.42447 0.56661 0.55539 0.06989  -0.03484 -0.13664 275 ARG A CZ  
2246 N NH1 . ARG A 281 ? 0.46717 0.56881 0.58622 0.08939  -0.03387 -0.12506 275 ARG A NH1 
2247 N NH2 . ARG A 281 ? 0.43484 0.57995 0.54725 0.05306  -0.05271 -0.13764 275 ARG A NH2 
2248 N N   . LEU A 282 ? 0.28682 0.40732 0.41363 -0.01024 0.01818  -0.17165 276 LEU A N   
2249 C CA  . LEU A 282 ? 0.30696 0.38492 0.41559 0.02668  0.03438  -0.16933 276 LEU A CA  
2250 C C   . LEU A 282 ? 0.35851 0.36055 0.43311 0.02999  0.04210  -0.13276 276 LEU A C   
2251 O O   . LEU A 282 ? 0.41939 0.33873 0.47441 0.06502  0.04930  -0.10593 276 LEU A O   
2252 C CB  . LEU A 282 ? 0.34965 0.41310 0.46079 0.02941  0.08789  -0.16331 276 LEU A CB  
2253 C CG  . LEU A 282 ? 0.42673 0.42236 0.50811 0.02645  0.10707  -0.17781 276 LEU A CG  
2254 C CD1 . LEU A 282 ? 0.46350 0.42898 0.53480 0.02158  0.13868  -0.18687 276 LEU A CD1 
2255 C CD2 . LEU A 282 ? 0.42801 0.41902 0.53119 0.03755  0.10129  -0.17441 276 LEU A CD2 
2256 N N   . PHE A 283 ? 0.32385 0.33882 0.38745 -0.01905 0.02390  -0.14248 277 PHE A N   
2257 C CA  . PHE A 283 ? 0.27934 0.33344 0.34949 -0.00310 0.00084  -0.12224 277 PHE A CA  
2258 C C   . PHE A 283 ? 0.28718 0.36656 0.34882 0.01389  0.01769  -0.14338 277 PHE A C   
2259 O O   . PHE A 283 ? 0.26152 0.37984 0.35423 -0.00113 0.02488  -0.12137 277 PHE A O   
2260 C CB  . PHE A 283 ? 0.29831 0.33687 0.28958 -0.01166 -0.00112 -0.07757 277 PHE A CB  
2261 C CG  . PHE A 283 ? 0.30537 0.34441 0.29353 -0.00758 -0.00764 -0.04397 277 PHE A CG  
2262 C CD1 . PHE A 283 ? 0.33634 0.35334 0.29603 -0.00959 0.01446  -0.01002 277 PHE A CD1 
2263 C CD2 . PHE A 283 ? 0.33184 0.33777 0.29513 0.02377  0.01998  -0.04139 277 PHE A CD2 
2264 C CE1 . PHE A 283 ? 0.34524 0.33966 0.30044 0.02173  0.02633  -0.00577 277 PHE A CE1 
2265 C CE2 . PHE A 283 ? 0.35077 0.32818 0.27129 0.02534  0.01619  -0.02297 277 PHE A CE2 
2266 C CZ  . PHE A 283 ? 0.34631 0.32312 0.27953 0.02990  0.00113  -0.02234 277 PHE A CZ  
2267 N N   . PRO A 284 ? 0.33662 0.41406 0.40917 0.02024  0.00773  -0.15174 278 PRO A N   
2268 C CA  . PRO A 284 ? 0.35408 0.44889 0.42741 0.01224  0.03114  -0.17212 278 PRO A CA  
2269 C C   . PRO A 284 ? 0.37395 0.49056 0.46509 -0.00148 0.04964  -0.14009 278 PRO A C   
2270 O O   . PRO A 284 ? 0.37829 0.52154 0.47721 -0.01435 0.08495  -0.10314 278 PRO A O   
2271 C CB  . PRO A 284 ? 0.38494 0.42792 0.42406 0.02818  0.03124  -0.18907 278 PRO A CB  
2272 C CG  . PRO A 284 ? 0.38664 0.41781 0.42713 0.02588  0.04995  -0.18064 278 PRO A CG  
2273 C CD  . PRO A 284 ? 0.35585 0.39704 0.42956 0.02888  0.03209  -0.17537 278 PRO A CD  
2274 N N   . ASN A 285 ? 0.32918 0.48651 0.46080 0.02344  -0.00774 -0.13395 279 ASN A N   
2275 C CA  . ASN A 285 ? 0.32253 0.47903 0.48798 0.00347  0.00952  -0.14457 279 ASN A CA  
2276 C C   . ASN A 285 ? 0.28271 0.46562 0.41561 -0.00803 0.03835  -0.13501 279 ASN A C   
2277 O O   . ASN A 285 ? 0.30979 0.48686 0.43449 -0.02549 0.09067  -0.13024 279 ASN A O   
2278 C CB  . ASN A 285 ? 0.34906 0.49420 0.53334 0.02631  0.01518  -0.14515 279 ASN A CB  
2279 C CG  . ASN A 285 ? 0.40065 0.51626 0.56367 0.05593  0.05142  -0.12834 279 ASN A CG  
2280 O OD1 . ASN A 285 ? 0.40866 0.53278 0.57075 0.06911  0.06366  -0.13459 279 ASN A OD1 
2281 N ND2 . ASN A 285 ? 0.42740 0.51472 0.58156 0.05789  0.06236  -0.11179 279 ASN A ND2 
2282 N N   . ALA A 286 ? 0.23938 0.43232 0.34471 0.02695  0.03768  -0.08810 280 ALA A N   
2283 C CA  . ALA A 286 ? 0.21717 0.40382 0.29812 0.00485  0.05959  -0.07001 280 ALA A CA  
2284 C C   . ALA A 286 ? 0.26959 0.39631 0.27055 -0.01602 0.08278  -0.03883 280 ALA A C   
2285 O O   . ALA A 286 ? 0.31649 0.40121 0.27386 -0.01240 0.08350  -0.03900 280 ALA A O   
2286 C CB  . ALA A 286 ? 0.18724 0.39890 0.29657 0.01521  0.10285  -0.08481 280 ALA A CB  
2287 N N   . ASP A 287 ? 0.24888 0.36799 0.27513 -0.01411 0.09717  -0.01193 281 ASP A N   
2288 C CA  . ASP A 287 ? 0.27555 0.36369 0.24857 -0.05612 0.09204  -0.02965 281 ASP A CA  
2289 C C   . ASP A 287 ? 0.29826 0.35877 0.21275 -0.03824 0.07193  -0.00434 281 ASP A C   
2290 O O   . ASP A 287 ? 0.29361 0.34922 0.22869 -0.04593 0.06772  -0.03434 281 ASP A O   
2291 C CB  . ASP A 287 ? 0.26832 0.36897 0.28814 -0.08453 0.07558  -0.05483 281 ASP A CB  
2292 C CG  . ASP A 287 ? 0.26119 0.38090 0.37634 -0.08742 0.06407  -0.05791 281 ASP A CG  
2293 O OD1 . ASP A 287 ? 0.26848 0.38021 0.39221 -0.06461 0.05242  -0.06142 281 ASP A OD1 
2294 O OD2 . ASP A 287 ? 0.22130 0.37924 0.42855 -0.10071 0.05021  -0.04471 281 ASP A OD2 
2295 N N   . SER A 288 ? 0.34758 0.37998 0.19494 -0.03346 0.05212  -0.00474 282 SER A N   
2296 C CA  . SER A 288 ? 0.35544 0.35841 0.15690 -0.00781 0.02007  0.01988  282 SER A CA  
2297 C C   . SER A 288 ? 0.33669 0.32155 0.17228 -0.03220 0.03847  0.03128  282 SER A C   
2298 O O   . SER A 288 ? 0.32358 0.30184 0.18886 -0.05996 0.06250  0.00847  282 SER A O   
2299 C CB  . SER A 288 ? 0.38660 0.38010 0.23940 -0.05790 0.04188  0.00601  282 SER A CB  
2300 O OG  . SER A 288 ? 0.36419 0.41633 0.29346 -0.02959 0.04650  -0.00117 282 SER A OG  
2301 N N   . LYS A 289 ? 0.33153 0.31923 0.18547 -0.02953 0.05609  0.02346  283 LYS A N   
2302 C CA  . LYS A 289 ? 0.30038 0.29071 0.19160 -0.03555 0.05647  0.03610  283 LYS A CA  
2303 C C   . LYS A 289 ? 0.24544 0.26912 0.19683 -0.01878 0.06462  0.03307  283 LYS A C   
2304 O O   . LYS A 289 ? 0.26005 0.26035 0.21533 -0.01856 0.06430  -0.00566 283 LYS A O   
2305 C CB  . LYS A 289 ? 0.31319 0.28776 0.22530 -0.08857 0.08473  0.04160  283 LYS A CB  
2306 C CG  . LYS A 289 ? 0.37900 0.28727 0.24851 -0.11247 0.09664  0.05286  283 LYS A CG  
2307 C CD  . LYS A 289 ? 0.41271 0.30781 0.27016 -0.13822 0.08500  0.04321  283 LYS A CD  
2308 C CE  . LYS A 289 ? 0.47454 0.33953 0.29393 -0.14789 0.06034  0.04040  283 LYS A CE  
2309 N NZ  . LYS A 289 ? 0.49941 0.36142 0.30506 -0.16105 0.07711  0.02941  283 LYS A NZ  
2310 N N   . ALA A 290 ? 0.23178 0.27129 0.21152 -0.04807 0.08279  0.03805  284 ALA A N   
2311 C CA  . ALA A 290 ? 0.21396 0.26973 0.20467 -0.03699 0.05479  0.04012  284 ALA A CA  
2312 C C   . ALA A 290 ? 0.23896 0.27701 0.18796 -0.04120 0.03046  0.01066  284 ALA A C   
2313 O O   . ALA A 290 ? 0.22509 0.25828 0.18237 -0.01293 0.03094  0.01814  284 ALA A O   
2314 C CB  . ALA A 290 ? 0.22989 0.26058 0.22857 -0.03436 0.02614  0.04098  284 ALA A CB  
2315 N N   . LEU A 291 ? 0.23971 0.27135 0.16922 -0.05450 0.02595  -0.02288 285 LEU A N   
2316 C CA  . LEU A 291 ? 0.21788 0.27665 0.16427 -0.03987 0.01974  -0.03495 285 LEU A CA  
2317 C C   . LEU A 291 ? 0.23938 0.26324 0.16239 -0.03570 0.00897  -0.00872 285 LEU A C   
2318 O O   . LEU A 291 ? 0.23105 0.29361 0.17508 -0.00744 0.02055  -0.00847 285 LEU A O   
2319 C CB  . LEU A 291 ? 0.23321 0.27397 0.16944 -0.02202 0.05059  -0.02060 285 LEU A CB  
2320 C CG  . LEU A 291 ? 0.24575 0.28607 0.15747 -0.00458 0.05066  -0.02999 285 LEU A CG  
2321 C CD1 . LEU A 291 ? 0.28674 0.30204 0.16095 0.00458  0.03165  -0.06215 285 LEU A CD1 
2322 C CD2 . LEU A 291 ? 0.23698 0.28806 0.18389 -0.00777 0.02681  -0.01157 285 LEU A CD2 
2323 N N   . ASP A 292 ? 0.26167 0.23054 0.17228 -0.01382 0.04742  0.00403  286 ASP A N   
2324 C CA  . ASP A 292 ? 0.28104 0.23968 0.18189 -0.02108 0.07410  0.01628  286 ASP A CA  
2325 C C   . ASP A 292 ? 0.25940 0.24507 0.18771 -0.00663 0.05783  -0.00310 286 ASP A C   
2326 O O   . ASP A 292 ? 0.25072 0.28091 0.19307 0.00142  0.04323  0.00069  286 ASP A O   
2327 C CB  . ASP A 292 ? 0.35916 0.24377 0.21272 -0.01428 0.04856  0.02650  286 ASP A CB  
2328 C CG  . ASP A 292 ? 0.37266 0.28803 0.22126 0.00215  -0.02269 -0.00964 286 ASP A CG  
2329 O OD1 . ASP A 292 ? 0.41526 0.31861 0.28194 0.02703  -0.04594 -0.02146 286 ASP A OD1 
2330 O OD2 . ASP A 292 ? 0.35944 0.29367 0.21500 -0.00617 -0.00466 -0.00987 286 ASP A OD2 
2331 N N   . LEU A 293 ? 0.25875 0.22368 0.18152 -0.00978 0.05937  -0.00407 287 LEU A N   
2332 C CA  . LEU A 293 ? 0.24669 0.23146 0.14840 -0.02135 0.02717  -0.00245 287 LEU A CA  
2333 C C   . LEU A 293 ? 0.21217 0.22976 0.17519 0.00167  0.02968  0.00657  287 LEU A C   
2334 O O   . LEU A 293 ? 0.19860 0.23181 0.19442 -0.00209 0.01111  -0.00480 287 LEU A O   
2335 C CB  . LEU A 293 ? 0.24136 0.23737 0.15330 -0.02839 0.05156  -0.03736 287 LEU A CB  
2336 C CG  . LEU A 293 ? 0.20499 0.24085 0.12310 -0.00509 0.02663  -0.03304 287 LEU A CG  
2337 C CD1 . LEU A 293 ? 0.19324 0.24530 0.15238 -0.00467 0.04716  -0.01154 287 LEU A CD1 
2338 C CD2 . LEU A 293 ? 0.19624 0.25662 0.17002 0.00637  -0.02116 -0.02750 287 LEU A CD2 
2339 N N   . LEU A 294 ? 0.20016 0.21588 0.18485 0.00562  0.02185  -0.00454 288 LEU A N   
2340 C CA  . LEU A 294 ? 0.19226 0.20108 0.18528 0.01647  0.00510  -0.01984 288 LEU A CA  
2341 C C   . LEU A 294 ? 0.19348 0.22265 0.18627 0.00157  0.04470  0.00822  288 LEU A C   
2342 O O   . LEU A 294 ? 0.18232 0.22502 0.18858 0.00675  0.06354  0.00949  288 LEU A O   
2343 C CB  . LEU A 294 ? 0.18463 0.16097 0.17544 0.01324  0.00767  -0.00749 288 LEU A CB  
2344 C CG  . LEU A 294 ? 0.20741 0.18181 0.15074 -0.01014 0.01040  -0.01254 288 LEU A CG  
2345 C CD1 . LEU A 294 ? 0.21780 0.20263 0.13566 -0.02213 0.00751  -0.01497 288 LEU A CD1 
2346 C CD2 . LEU A 294 ? 0.25255 0.20278 0.17551 0.02984  0.03357  0.00455  288 LEU A CD2 
2347 N N   . ASP A 295 ? 0.21687 0.22890 0.17672 0.00371  -0.02287 -0.00441 289 ASP A N   
2348 C CA  . ASP A 295 ? 0.22987 0.25294 0.15646 0.03464  -0.01819 0.00133  289 ASP A CA  
2349 C C   . ASP A 295 ? 0.19533 0.24410 0.19042 0.02493  0.00443  -0.00336 289 ASP A C   
2350 O O   . ASP A 295 ? 0.19039 0.26243 0.19895 0.02392  0.03811  -0.00804 289 ASP A O   
2351 C CB  . ASP A 295 ? 0.26537 0.30514 0.18605 0.04529  -0.03110 0.02680  289 ASP A CB  
2352 C CG  . ASP A 295 ? 0.27884 0.34463 0.25680 0.04501  -0.02901 0.01427  289 ASP A CG  
2353 O OD1 . ASP A 295 ? 0.28152 0.34545 0.28920 0.01949  -0.00259 -0.01761 289 ASP A OD1 
2354 O OD2 . ASP A 295 ? 0.30306 0.38661 0.28096 0.05093  0.00104  0.03571  289 ASP A OD2 
2355 N N   . LYS A 296 ? 0.22164 0.23336 0.17728 -0.00081 0.00620  -0.00651 290 LYS A N   
2356 C CA  . LYS A 296 ? 0.21658 0.21754 0.14739 -0.01230 0.01065  0.00787  290 LYS A CA  
2357 C C   . LYS A 296 ? 0.23304 0.24609 0.16750 -0.00051 0.01904  0.01456  290 LYS A C   
2358 O O   . LYS A 296 ? 0.22006 0.28753 0.18896 0.02721  0.03810  0.00028  290 LYS A O   
2359 C CB  . LYS A 296 ? 0.24431 0.21652 0.15332 0.00041  -0.01934 0.00472  290 LYS A CB  
2360 C CG  . LYS A 296 ? 0.27812 0.24932 0.16791 0.00346  -0.02120 0.03752  290 LYS A CG  
2361 C CD  A LYS A 296 ? 0.34873 0.28812 0.16316 -0.03125 -0.02442 0.04309  290 LYS A CD  
2362 C CD  B LYS A 296 ? 0.28122 0.25275 0.17683 0.01574  -0.03741 0.04110  290 LYS A CD  
2363 C CE  A LYS A 296 ? 0.40496 0.33110 0.16887 -0.02807 0.01045  0.05091  290 LYS A CE  
2364 C CE  B LYS A 296 ? 0.27538 0.25534 0.18708 0.04037  -0.04708 0.05306  290 LYS A CE  
2365 N NZ  A LYS A 296 ? 0.44118 0.36174 0.15741 -0.03157 -0.01312 0.06253  290 LYS A NZ  
2366 N NZ  B LYS A 296 ? 0.27075 0.25640 0.19384 0.05886  -0.06167 0.06932  290 LYS A NZ  
2367 N N   . MET A 297 ? 0.19770 0.21952 0.15697 0.00614  -0.03699 0.05076  291 MET A N   
2368 C CA  . MET A 297 ? 0.18263 0.21303 0.14833 -0.00602 0.00241  0.00359  291 MET A CA  
2369 C C   . MET A 297 ? 0.17678 0.22636 0.15813 -0.00995 0.02742  -0.01800 291 MET A C   
2370 O O   . MET A 297 ? 0.21142 0.21491 0.19081 -0.01165 0.04762  -0.02614 291 MET A O   
2371 C CB  A MET A 297 ? 0.13495 0.20043 0.17201 -0.03600 -0.03036 -0.00124 291 MET A CB  
2372 C CB  B MET A 297 ? 0.16909 0.21233 0.15441 -0.00227 -0.02286 -0.00791 291 MET A CB  
2373 C CG  A MET A 297 ? 0.15575 0.20655 0.18669 -0.04292 -0.04601 -0.02516 291 MET A CG  
2374 C CG  B MET A 297 ? 0.19769 0.22942 0.15704 0.01836  -0.04297 -0.03585 291 MET A CG  
2375 S SD  A MET A 297 ? 0.16022 0.20911 0.23473 -0.01436 0.00134  -0.02915 291 MET A SD  
2376 S SD  B MET A 297 ? 0.22494 0.23286 0.18429 0.05787  0.02108  -0.02117 291 MET A SD  
2377 C CE  A MET A 297 ? 0.20250 0.21744 0.25117 0.00233  0.06570  -0.01566 291 MET A CE  
2378 C CE  B MET A 297 ? 0.23163 0.22279 0.20099 0.04398  -0.00533 -0.01985 291 MET A CE  
2379 N N   . LEU A 298 ? 0.16198 0.19855 0.19111 -0.00265 -0.01750 -0.02683 292 LEU A N   
2380 C CA  . LEU A 298 ? 0.17477 0.19053 0.18141 0.01247  -0.00744 -0.02503 292 LEU A CA  
2381 C C   . LEU A 298 ? 0.22754 0.19883 0.20372 0.02697  0.02402  -0.00548 292 LEU A C   
2382 O O   . LEU A 298 ? 0.27174 0.21921 0.31776 0.03338  -0.06957 -0.03567 292 LEU A O   
2383 C CB  . LEU A 298 ? 0.16387 0.20511 0.17687 0.02999  0.02245  0.00241  292 LEU A CB  
2384 C CG  . LEU A 298 ? 0.18319 0.22036 0.16136 0.03065  0.03902  -0.00128 292 LEU A CG  
2385 C CD1 . LEU A 298 ? 0.25175 0.22342 0.19932 0.02135  0.06097  -0.01941 292 LEU A CD1 
2386 C CD2 . LEU A 298 ? 0.21242 0.23298 0.16147 0.04137  0.01241  0.00790  292 LEU A CD2 
2387 N N   . THR A 299 ? 0.20423 0.21907 0.20526 0.02389  0.01598  0.01502  293 THR A N   
2388 C CA  . THR A 299 ? 0.21474 0.23224 0.21264 0.03218  0.00825  0.01665  293 THR A CA  
2389 C C   . THR A 299 ? 0.17394 0.25108 0.18781 0.03464  -0.02630 0.01670  293 THR A C   
2390 O O   . THR A 299 ? 0.19209 0.26901 0.19307 0.00447  0.00955  -0.00628 293 THR A O   
2391 C CB  . THR A 299 ? 0.28427 0.26111 0.25037 0.02185  0.01490  0.01905  293 THR A CB  
2392 O OG1 . THR A 299 ? 0.28507 0.29045 0.32186 0.06693  0.01336  0.07671  293 THR A OG1 
2393 C CG2 . THR A 299 ? 0.35512 0.28479 0.24008 0.00856  0.01824  -0.01269 293 THR A CG2 
2394 N N   . PHE A 300 ? 0.15796 0.26409 0.21372 0.03694  -0.03641 0.01335  294 PHE A N   
2395 C CA  . PHE A 300 ? 0.18583 0.29187 0.22728 0.03227  -0.00327 -0.03797 294 PHE A CA  
2396 C C   . PHE A 300 ? 0.20548 0.28936 0.23342 0.03565  -0.00893 -0.03811 294 PHE A C   
2397 O O   . PHE A 300 ? 0.22533 0.29078 0.23235 0.03715  -0.00724 -0.03607 294 PHE A O   
2398 C CB  . PHE A 300 ? 0.20370 0.31312 0.21692 0.00204  0.00996  -0.05757 294 PHE A CB  
2399 C CG  . PHE A 300 ? 0.21624 0.34683 0.22304 -0.01235 0.00647  -0.02863 294 PHE A CG  
2400 C CD1 . PHE A 300 ? 0.25649 0.36225 0.21845 -0.02981 0.02334  -0.04492 294 PHE A CD1 
2401 C CD2 . PHE A 300 ? 0.19084 0.36439 0.24617 -0.02529 0.00155  -0.02868 294 PHE A CD2 
2402 C CE1 . PHE A 300 ? 0.28424 0.38549 0.20923 -0.02311 0.01681  -0.02845 294 PHE A CE1 
2403 C CE2 . PHE A 300 ? 0.23867 0.38014 0.22927 -0.02080 -0.01694 -0.01172 294 PHE A CE2 
2404 C CZ  . PHE A 300 ? 0.28608 0.38887 0.20218 -0.04379 -0.00147 0.00115  294 PHE A CZ  
2405 N N   . ASN A 301 ? 0.19686 0.27729 0.24185 0.05731  -0.02485 -0.04809 295 ASN A N   
2406 C CA  . ASN A 301 ? 0.19342 0.29305 0.20478 0.05071  -0.02884 -0.03747 295 ASN A CA  
2407 C C   . ASN A 301 ? 0.18350 0.28484 0.20688 0.02596  -0.02872 -0.01447 295 ASN A C   
2408 O O   . ASN A 301 ? 0.20849 0.27142 0.21008 0.01381  -0.01859 -0.00688 295 ASN A O   
2409 C CB  . ASN A 301 ? 0.19265 0.32132 0.23797 0.10680  -0.06401 -0.04055 295 ASN A CB  
2410 C CG  . ASN A 301 ? 0.23232 0.35955 0.26323 0.10455  -0.04613 -0.05221 295 ASN A CG  
2411 O OD1 . ASN A 301 ? 0.26874 0.39739 0.28519 0.09981  -0.02185 -0.07295 295 ASN A OD1 
2412 N ND2 . ASN A 301 ? 0.24671 0.36568 0.26587 0.09446  -0.05478 -0.04585 295 ASN A ND2 
2413 N N   . PRO A 302 ? 0.15998 0.29275 0.19083 0.00952  0.01246  -0.02748 296 PRO A N   
2414 C CA  . PRO A 302 ? 0.18796 0.29634 0.19296 0.00130  0.04107  -0.03443 296 PRO A CA  
2415 C C   . PRO A 302 ? 0.17435 0.30772 0.21430 0.03305  -0.01793 -0.03382 296 PRO A C   
2416 O O   . PRO A 302 ? 0.21333 0.31896 0.27077 0.02668  -0.03481 -0.02944 296 PRO A O   
2417 C CB  . PRO A 302 ? 0.17818 0.29718 0.19299 -0.00647 0.02927  -0.03485 296 PRO A CB  
2418 C CG  . PRO A 302 ? 0.16720 0.31303 0.19200 0.00290  0.00424  -0.06143 296 PRO A CG  
2419 C CD  . PRO A 302 ? 0.17999 0.31688 0.20548 -0.01350 0.07001  -0.03884 296 PRO A CD  
2420 N N   . HIS A 303 ? 0.20067 0.34817 0.20895 0.05686  -0.00027 -0.03052 297 HIS A N   
2421 C CA  . HIS A 303 ? 0.20213 0.38100 0.26815 0.09414  0.00548  -0.01620 297 HIS A CA  
2422 C C   . HIS A 303 ? 0.28395 0.35405 0.27421 0.07143  0.02345  -0.00581 297 HIS A C   
2423 O O   . HIS A 303 ? 0.34013 0.36826 0.32327 0.04949  0.02993  -0.03755 297 HIS A O   
2424 C CB  . HIS A 303 ? 0.19288 0.43808 0.31839 0.09632  0.01490  -0.01515 297 HIS A CB  
2425 C CG  . HIS A 303 ? 0.22589 0.48144 0.36772 0.06915  0.04668  -0.02666 297 HIS A CG  
2426 N ND1 . HIS A 303 ? 0.24909 0.50586 0.39820 0.06144  0.08788  -0.02171 297 HIS A ND1 
2427 C CD2 . HIS A 303 ? 0.25784 0.50346 0.39009 0.05319  0.06887  -0.03301 297 HIS A CD2 
2428 C CE1 . HIS A 303 ? 0.24871 0.51745 0.40819 0.06794  0.09012  -0.03686 297 HIS A CE1 
2429 N NE2 . HIS A 303 ? 0.24963 0.51785 0.40655 0.05103  0.10006  -0.04310 297 HIS A NE2 
2430 N N   . LYS A 304 ? 0.24494 0.33295 0.19206 0.05725  -0.00363 -0.00439 298 LYS A N   
2431 C CA  . LYS A 304 ? 0.21095 0.34128 0.23209 0.02531  -0.01962 -0.02095 298 LYS A CA  
2432 C C   . LYS A 304 ? 0.18635 0.30081 0.23647 0.03295  -0.00566 -0.00570 298 LYS A C   
2433 O O   . LYS A 304 ? 0.22350 0.30883 0.26164 0.02940  0.00008  0.02226  298 LYS A O   
2434 C CB  . LYS A 304 ? 0.19707 0.39623 0.22778 0.02727  -0.06575 0.01143  298 LYS A CB  
2435 C CG  . LYS A 304 ? 0.21291 0.42574 0.25384 0.02982  -0.09263 -0.00261 298 LYS A CG  
2436 C CD  . LYS A 304 ? 0.19329 0.43251 0.24822 0.01137  -0.10182 -0.01818 298 LYS A CD  
2437 C CE  . LYS A 304 ? 0.23096 0.44510 0.26490 0.01624  -0.07442 -0.02168 298 LYS A CE  
2438 N NZ  . LYS A 304 ? 0.25980 0.45334 0.24412 -0.00098 -0.04753 -0.01074 298 LYS A NZ  
2439 N N   . ARG A 305 ? 0.15432 0.25606 0.24074 0.03628  -0.01739 0.00607  299 ARG A N   
2440 C CA  . ARG A 305 ? 0.15979 0.21799 0.21657 0.05035  -0.04217 0.03612  299 ARG A CA  
2441 C C   . ARG A 305 ? 0.17091 0.20358 0.22471 0.03749  -0.01580 0.03643  299 ARG A C   
2442 O O   . ARG A 305 ? 0.23503 0.21413 0.24596 0.01904  0.01729  -0.01372 299 ARG A O   
2443 C CB  . ARG A 305 ? 0.15628 0.20153 0.23187 0.07478  -0.02132 0.07127  299 ARG A CB  
2444 C CG  . ARG A 305 ? 0.17226 0.19450 0.23240 0.04463  0.01612  0.06614  299 ARG A CG  
2445 C CD  . ARG A 305 ? 0.17517 0.18356 0.18879 -0.00598 0.01726  0.04542  299 ARG A CD  
2446 N NE  . ARG A 305 ? 0.14893 0.20198 0.18053 -0.00039 -0.00097 -0.00173 299 ARG A NE  
2447 C CZ  . ARG A 305 ? 0.19856 0.21339 0.16398 -0.01245 0.03087  -0.00956 299 ARG A CZ  
2448 N NH1 . ARG A 305 ? 0.19825 0.22969 0.17166 0.01407  0.04496  -0.01624 299 ARG A NH1 
2449 N NH2 . ARG A 305 ? 0.16954 0.22684 0.18219 -0.00846 0.01511  -0.01098 299 ARG A NH2 
2450 N N   . ILE A 306 ? 0.18923 0.20375 0.19899 0.00833  0.00457  0.06799  300 ILE A N   
2451 C CA  . ILE A 306 ? 0.17679 0.21389 0.20095 0.02335  0.00857  0.03115  300 ILE A CA  
2452 C C   . ILE A 306 ? 0.21202 0.21881 0.19439 0.02902  0.02247  0.01335  300 ILE A C   
2453 O O   . ILE A 306 ? 0.25644 0.19737 0.17931 0.02865  0.00297  0.02101  300 ILE A O   
2454 C CB  . ILE A 306 ? 0.18639 0.20318 0.23545 0.01817  0.02928  0.04750  300 ILE A CB  
2455 C CG1 . ILE A 306 ? 0.20643 0.17334 0.24493 0.01072  0.07737  0.03891  300 ILE A CG1 
2456 C CG2 . ILE A 306 ? 0.21090 0.21781 0.23024 0.03994  0.04536  0.01383  300 ILE A CG2 
2457 C CD1 . ILE A 306 ? 0.23254 0.17438 0.27807 -0.00351 0.09764  0.00088  300 ILE A CD1 
2458 N N   . GLU A 307 ? 0.19083 0.23306 0.19083 0.01750  0.01278  -0.00496 301 GLU A N   
2459 C CA  . GLU A 307 ? 0.18109 0.23291 0.19662 0.05001  0.00329  -0.03760 301 GLU A CA  
2460 C C   . GLU A 307 ? 0.22860 0.21696 0.18102 0.03935  -0.01315 -0.03738 301 GLU A C   
2461 O O   . GLU A 307 ? 0.27922 0.21168 0.16047 0.04252  0.00832  0.00355  301 GLU A O   
2462 C CB  . GLU A 307 ? 0.21226 0.25655 0.21403 0.05915  0.02561  -0.00518 301 GLU A CB  
2463 C CG  . GLU A 307 ? 0.21269 0.28513 0.25334 0.06793  0.01852  0.01029  301 GLU A CG  
2464 C CD  . GLU A 307 ? 0.26489 0.29117 0.35643 0.02520  0.06900  -0.02589 301 GLU A CD  
2465 O OE1 . GLU A 307 ? 0.29301 0.27823 0.37352 0.01832  0.09390  -0.02033 301 GLU A OE1 
2466 O OE2 . GLU A 307 ? 0.30168 0.32099 0.42306 0.01284  0.07182  -0.03402 301 GLU A OE2 
2467 N N   . VAL A 308 ? 0.20968 0.19627 0.19007 0.05173  -0.03870 -0.02654 302 VAL A N   
2468 C CA  . VAL A 308 ? 0.17840 0.19366 0.17781 0.02977  -0.06520 0.01372  302 VAL A CA  
2469 C C   . VAL A 308 ? 0.19033 0.19766 0.22694 0.02295  -0.00441 0.02657  302 VAL A C   
2470 O O   . VAL A 308 ? 0.22063 0.19769 0.21195 0.00044  0.01825  0.02848  302 VAL A O   
2471 C CB  . VAL A 308 ? 0.18340 0.21153 0.15152 0.05306  -0.01940 -0.01684 302 VAL A CB  
2472 C CG1 . VAL A 308 ? 0.23560 0.20761 0.13525 0.05297  -0.01089 -0.04797 302 VAL A CG1 
2473 C CG2 . VAL A 308 ? 0.16267 0.20892 0.19600 0.03611  -0.00397 -0.00345 302 VAL A CG2 
2474 N N   . GLU A 309 ? 0.18645 0.17264 0.23753 0.00101  -0.00083 0.00157  303 GLU A N   
2475 C CA  . GLU A 309 ? 0.20322 0.21394 0.25370 0.00179  -0.01159 -0.02571 303 GLU A CA  
2476 C C   . GLU A 309 ? 0.24138 0.21032 0.24047 0.00073  -0.02057 0.00726  303 GLU A C   
2477 O O   . GLU A 309 ? 0.24327 0.19597 0.26372 -0.00267 0.00287  0.05353  303 GLU A O   
2478 C CB  . GLU A 309 ? 0.25778 0.24280 0.26715 0.04633  0.02452  -0.08372 303 GLU A CB  
2479 C CG  . GLU A 309 ? 0.25171 0.25895 0.26119 0.08653  -0.01712 -0.10089 303 GLU A CG  
2480 C CD  . GLU A 309 ? 0.36426 0.25056 0.28635 0.09196  0.03479  -0.06664 303 GLU A CD  
2481 O OE1 . GLU A 309 ? 0.39352 0.25953 0.28448 0.12048  0.04264  -0.02746 303 GLU A OE1 
2482 O OE2 . GLU A 309 ? 0.40867 0.25022 0.30895 0.07454  0.09110  -0.08328 303 GLU A OE2 
2483 N N   . GLN A 310 ? 0.27017 0.22336 0.20171 0.01645  -0.03931 0.00089  304 GLN A N   
2484 C CA  . GLN A 310 ? 0.28589 0.22366 0.20844 0.02667  -0.04307 0.01528  304 GLN A CA  
2485 C C   . GLN A 310 ? 0.30418 0.19523 0.22286 0.01489  0.00468  0.02623  304 GLN A C   
2486 O O   . GLN A 310 ? 0.30987 0.19589 0.24216 0.00707  -0.00407 0.04308  304 GLN A O   
2487 C CB  . GLN A 310 ? 0.30922 0.24104 0.20866 0.02018  -0.05410 -0.01840 304 GLN A CB  
2488 C CG  . GLN A 310 ? 0.28997 0.25518 0.24403 0.04246  -0.05683 -0.02451 304 GLN A CG  
2489 C CD  . GLN A 310 ? 0.25881 0.24813 0.25894 0.06546  -0.06656 -0.02363 304 GLN A CD  
2490 O OE1 . GLN A 310 ? 0.29654 0.26639 0.29436 0.10751  -0.05845 0.00015  304 GLN A OE1 
2491 N NE2 . GLN A 310 ? 0.29983 0.24003 0.26440 0.04836  -0.01118 -0.01452 304 GLN A NE2 
2492 N N   . ALA A 311 ? 0.24922 0.16315 0.20555 0.01115  -0.04049 0.02986  305 ALA A N   
2493 C CA  . ALA A 311 ? 0.24613 0.14176 0.21956 -0.01715 -0.00838 0.02710  305 ALA A CA  
2494 C C   . ALA A 311 ? 0.26552 0.15689 0.19432 -0.03565 0.00721  0.01774  305 ALA A C   
2495 O O   . ALA A 311 ? 0.29967 0.17348 0.18696 -0.00818 0.03257  0.04346  305 ALA A O   
2496 C CB  . ALA A 311 ? 0.25502 0.14994 0.17383 -0.02886 -0.00149 0.04396  305 ALA A CB  
2497 N N   . LEU A 312 ? 0.26794 0.15172 0.20109 -0.03596 0.00730  0.01716  306 LEU A N   
2498 C CA  . LEU A 312 ? 0.25523 0.17194 0.17514 -0.03729 0.01488  0.02520  306 LEU A CA  
2499 C C   . LEU A 312 ? 0.28100 0.18539 0.18488 -0.01540 0.02336  0.05413  306 LEU A C   
2500 O O   . LEU A 312 ? 0.29692 0.19308 0.18484 -0.00870 0.04464  0.02381  306 LEU A O   
2501 C CB  . LEU A 312 ? 0.24760 0.15277 0.16062 0.00390  0.03059  0.00515  306 LEU A CB  
2502 C CG  . LEU A 312 ? 0.20349 0.14173 0.16619 0.02116  -0.00545 0.00890  306 LEU A CG  
2503 C CD1 . LEU A 312 ? 0.19844 0.16813 0.16655 0.00612  0.02093  -0.02304 306 LEU A CD1 
2504 C CD2 . LEU A 312 ? 0.20662 0.17359 0.23207 0.04039  -0.00823 0.04536  306 LEU A CD2 
2505 N N   . ALA A 313 ? 0.32538 0.17295 0.18043 0.00327  -0.00021 0.03785  307 ALA A N   
2506 C CA  . ALA A 313 ? 0.33771 0.18170 0.18926 0.01833  -0.00560 0.03999  307 ALA A CA  
2507 C C   . ALA A 313 ? 0.35080 0.17998 0.19418 -0.01491 0.02600  0.04235  307 ALA A C   
2508 O O   . ALA A 313 ? 0.39623 0.19165 0.22315 -0.02220 0.02879  0.06003  307 ALA A O   
2509 C CB  . ALA A 313 ? 0.36879 0.17057 0.21387 0.01249  -0.00802 0.03350  307 ALA A CB  
2510 N N   . HIS A 314 ? 0.32571 0.17736 0.17558 -0.02606 0.01558  0.02050  308 HIS A N   
2511 C CA  . HIS A 314 ? 0.33661 0.18161 0.16570 -0.02823 0.04035  0.04166  308 HIS A CA  
2512 C C   . HIS A 314 ? 0.33950 0.22237 0.15157 -0.01036 0.01671  0.06808  308 HIS A C   
2513 O O   . HIS A 314 ? 0.31870 0.22846 0.21594 0.01316  0.05407  0.05124  308 HIS A O   
2514 C CB  . HIS A 314 ? 0.35451 0.17654 0.16794 -0.04784 0.04830  0.01400  308 HIS A CB  
2515 C CG  . HIS A 314 ? 0.35814 0.20001 0.18005 -0.01743 0.08284  0.01786  308 HIS A CG  
2516 N ND1 . HIS A 314 ? 0.29027 0.19799 0.20967 -0.01528 0.05791  0.00704  308 HIS A ND1 
2517 C CD2 . HIS A 314 ? 0.34109 0.19364 0.15805 -0.02686 0.05020  0.02886  308 HIS A CD2 
2518 C CE1 . HIS A 314 ? 0.31210 0.19178 0.20752 -0.02931 -0.01004 0.01620  308 HIS A CE1 
2519 N NE2 . HIS A 314 ? 0.34010 0.21239 0.19096 0.00890  0.04284  0.02826  308 HIS A NE2 
2520 N N   . PRO A 315 ? 0.34455 0.25782 0.16416 0.00439  0.04016  0.06441  309 PRO A N   
2521 C CA  . PRO A 315 ? 0.36830 0.27053 0.17940 -0.01353 0.06396  0.08075  309 PRO A CA  
2522 C C   . PRO A 315 ? 0.34302 0.26074 0.19793 -0.03177 0.06114  0.06132  309 PRO A C   
2523 O O   . PRO A 315 ? 0.34306 0.27242 0.19427 -0.04658 0.05999  0.04331  309 PRO A O   
2524 C CB  . PRO A 315 ? 0.36886 0.29751 0.22488 0.01297  0.04570  0.09536  309 PRO A CB  
2525 C CG  . PRO A 315 ? 0.34571 0.29383 0.23707 0.00222  0.06158  0.10148  309 PRO A CG  
2526 C CD  . PRO A 315 ? 0.38134 0.27181 0.19295 0.00195  0.06003  0.09026  309 PRO A CD  
2527 N N   . TYR A 316 ? 0.36814 0.24850 0.19397 -0.02803 0.06200  0.05405  310 TYR A N   
2528 C CA  . TYR A 316 ? 0.32881 0.23497 0.18918 -0.03792 0.05473  0.02996  310 TYR A CA  
2529 C C   . TYR A 316 ? 0.29150 0.21593 0.21098 -0.04159 0.04497  0.02025  310 TYR A C   
2530 O O   . TYR A 316 ? 0.30227 0.21461 0.23050 -0.03884 0.04547  0.00364  310 TYR A O   
2531 C CB  . TYR A 316 ? 0.31003 0.22630 0.19076 -0.04944 0.04878  0.03835  310 TYR A CB  
2532 C CG  . TYR A 316 ? 0.26278 0.23507 0.22238 -0.04162 0.02801  0.02233  310 TYR A CG  
2533 C CD1 . TYR A 316 ? 0.27540 0.24439 0.26701 -0.01547 0.04622  -0.00931 310 TYR A CD1 
2534 C CD2 . TYR A 316 ? 0.27637 0.23760 0.21385 -0.01916 -0.00866 0.03507  310 TYR A CD2 
2535 C CE1 . TYR A 316 ? 0.30151 0.23804 0.28041 0.00163  0.05178  -0.00522 310 TYR A CE1 
2536 C CE2 . TYR A 316 ? 0.25236 0.22564 0.25803 -0.02210 0.02316  -0.01103 310 TYR A CE2 
2537 C CZ  . TYR A 316 ? 0.30266 0.23811 0.30792 0.01822  0.04508  0.00591  310 TYR A CZ  
2538 O OH  . TYR A 316 ? 0.34441 0.24764 0.33929 0.02545  0.05657  0.00550  310 TYR A OH  
2539 N N   . LEU A 317 ? 0.29249 0.18891 0.18604 -0.04498 0.06484  0.00997  311 LEU A N   
2540 C CA  . LEU A 317 ? 0.29393 0.19241 0.19806 -0.04079 0.09622  -0.00237 311 LEU A CA  
2541 C C   . LEU A 317 ? 0.29876 0.20485 0.20534 -0.05962 0.09840  0.00770  311 LEU A C   
2542 O O   . LEU A 317 ? 0.34757 0.22702 0.24203 -0.08805 0.10507  -0.03070 311 LEU A O   
2543 C CB  . LEU A 317 ? 0.27925 0.18538 0.18132 -0.03169 0.08718  0.03452  311 LEU A CB  
2544 C CG  . LEU A 317 ? 0.25293 0.20109 0.18206 0.01552  0.10477  0.06685  311 LEU A CG  
2545 C CD1 . LEU A 317 ? 0.30861 0.21365 0.19360 0.00077  0.12886  0.04246  311 LEU A CD1 
2546 C CD2 . LEU A 317 ? 0.22958 0.26656 0.25100 0.02022  0.07454  0.05298  311 LEU A CD2 
2547 N N   . GLU A 318 ? 0.30975 0.22334 0.22472 -0.05540 0.09736  0.02874  312 GLU A N   
2548 C CA  . GLU A 318 ? 0.39912 0.25388 0.24999 -0.08680 0.11144  0.03310  312 GLU A CA  
2549 C C   . GLU A 318 ? 0.36692 0.27531 0.25917 -0.10278 0.10695  0.00808  312 GLU A C   
2550 O O   . GLU A 318 ? 0.37781 0.27357 0.27941 -0.15951 0.04318  0.01462  312 GLU A O   
2551 C CB  . GLU A 318 ? 0.46711 0.23971 0.27738 -0.12312 0.07342  0.06247  312 GLU A CB  
2552 C CG  . GLU A 318 ? 0.53824 0.25069 0.31138 -0.13287 0.08758  0.05705  312 GLU A CG  
2553 C CD  . GLU A 318 ? 0.58148 0.27441 0.35420 -0.11733 0.10787  0.06584  312 GLU A CD  
2554 O OE1 . GLU A 318 ? 0.60740 0.29894 0.36629 -0.09363 0.10012  0.06649  312 GLU A OE1 
2555 O OE2 . GLU A 318 ? 0.59757 0.28242 0.36730 -0.09390 0.13608  0.08175  312 GLU A OE2 
2556 N N   . GLN A 319 ? 0.33900 0.31228 0.26861 -0.05242 0.11774  0.00032  313 GLN A N   
2557 C CA  A GLN A 319 ? 0.34761 0.32095 0.26552 -0.04348 0.11762  -0.05398 313 GLN A CA  
2558 C CA  B GLN A 319 ? 0.34453 0.31968 0.27112 -0.04079 0.13237  -0.02258 313 GLN A CA  
2559 C C   . GLN A 319 ? 0.32365 0.30160 0.25751 -0.05812 0.11897  -0.04092 313 GLN A C   
2560 O O   . GLN A 319 ? 0.34644 0.34929 0.29127 -0.03985 0.13024  -0.00053 313 GLN A O   
2561 C CB  A GLN A 319 ? 0.32648 0.36348 0.30050 0.00627  0.13123  -0.11638 313 GLN A CB  
2562 C CB  B GLN A 319 ? 0.31949 0.35799 0.30835 0.01084  0.17100  -0.03000 313 GLN A CB  
2563 C CG  A GLN A 319 ? 0.38387 0.40321 0.38936 -0.00956 0.13581  -0.12749 313 GLN A CG  
2564 C CG  B GLN A 319 ? 0.36014 0.38542 0.39166 0.00959  0.18856  0.01348  313 GLN A CG  
2565 C CD  A GLN A 319 ? 0.37460 0.39981 0.41939 0.00019  0.15478  -0.16002 313 GLN A CD  
2566 C CD  B GLN A 319 ? 0.34908 0.38073 0.42651 0.03973  0.22327  0.04340  313 GLN A CD  
2567 O OE1 A GLN A 319 ? 0.25998 0.35970 0.39343 0.02914  0.12288  -0.14327 313 GLN A OE1 
2568 O OE1 B GLN A 319 ? 0.31426 0.35928 0.42724 0.00520  0.20626  0.06891  313 GLN A OE1 
2569 N NE2 A GLN A 319 ? 0.42270 0.41267 0.47138 0.01015  0.19504  -0.17457 313 GLN A NE2 
2570 N NE2 B GLN A 319 ? 0.39027 0.40551 0.46037 0.00870  0.21458  0.04395  313 GLN A NE2 
2571 N N   . TYR A 320 ? 0.26264 0.25711 0.26850 -0.05025 0.15113  -0.02547 314 TYR A N   
2572 C CA  . TYR A 320 ? 0.25697 0.23722 0.25667 -0.06280 0.13315  0.00532  314 TYR A CA  
2573 C C   . TYR A 320 ? 0.28246 0.23668 0.26011 -0.05468 0.10473  0.00917  314 TYR A C   
2574 O O   . TYR A 320 ? 0.30280 0.26303 0.24717 -0.04777 0.08184  -0.00260 314 TYR A O   
2575 C CB  . TYR A 320 ? 0.24374 0.24833 0.30045 -0.05247 0.13104  0.00124  314 TYR A CB  
2576 C CG  . TYR A 320 ? 0.24054 0.28247 0.33779 -0.02773 0.10621  -0.01210 314 TYR A CG  
2577 C CD1 . TYR A 320 ? 0.25283 0.31711 0.39545 -0.01855 0.08253  -0.01908 314 TYR A CD1 
2578 C CD2 . TYR A 320 ? 0.27537 0.28805 0.36713 -0.04570 0.16455  -0.00110 314 TYR A CD2 
2579 C CE1 . TYR A 320 ? 0.31260 0.33655 0.43059 -0.01088 0.09604  -0.01409 314 TYR A CE1 
2580 C CE2 . TYR A 320 ? 0.26185 0.31001 0.39211 -0.04832 0.14507  0.01002  314 TYR A CE2 
2581 C CZ  . TYR A 320 ? 0.30759 0.33149 0.43346 -0.02407 0.13518  -0.00423 314 TYR A CZ  
2582 O OH  . TYR A 320 ? 0.33943 0.34905 0.47154 -0.04285 0.12991  0.03535  314 TYR A OH  
2583 N N   . TYR A 321 ? 0.27917 0.22789 0.24398 -0.05545 0.07354  0.01433  315 TYR A N   
2584 C CA  . TYR A 321 ? 0.30350 0.21252 0.25090 -0.05752 0.09954  0.00975  315 TYR A CA  
2585 C C   . TYR A 321 ? 0.32123 0.21003 0.23731 -0.05572 0.09286  0.00169  315 TYR A C   
2586 O O   . TYR A 321 ? 0.40920 0.23384 0.26079 -0.08646 0.09803  0.00783  315 TYR A O   
2587 C CB  . TYR A 321 ? 0.32141 0.23243 0.27269 -0.04632 0.09699  0.02803  315 TYR A CB  
2588 C CG  . TYR A 321 ? 0.33084 0.20799 0.24771 -0.01934 0.05627  0.03421  315 TYR A CG  
2589 C CD1 . TYR A 321 ? 0.32546 0.21864 0.23881 -0.00964 0.05316  0.03565  315 TYR A CD1 
2590 C CD2 . TYR A 321 ? 0.37042 0.22744 0.24274 0.00184  0.07028  0.04794  315 TYR A CD2 
2591 C CE1 . TYR A 321 ? 0.33954 0.20922 0.25240 -0.01906 0.00215  0.04848  315 TYR A CE1 
2592 C CE2 . TYR A 321 ? 0.39437 0.23595 0.27521 -0.00580 0.04754  0.04456  315 TYR A CE2 
2593 C CZ  . TYR A 321 ? 0.37736 0.22346 0.28560 0.00637  0.00931  0.05203  315 TYR A CZ  
2594 O OH  . TYR A 321 ? 0.38499 0.21854 0.32587 0.02334  -0.04223 0.05484  315 TYR A OH  
2595 N N   . ASP A 322 ? 0.34535 0.19597 0.20716 -0.02340 0.06629  -0.03293 316 ASP A N   
2596 C CA  . ASP A 322 ? 0.32110 0.19501 0.24892 -0.04013 0.05718  -0.01533 316 ASP A CA  
2597 C C   . ASP A 322 ? 0.30129 0.19552 0.22841 -0.01791 0.05314  0.01059  316 ASP A C   
2598 O O   . ASP A 322 ? 0.30187 0.19267 0.23716 -0.01902 0.05259  -0.00701 316 ASP A O   
2599 C CB  . ASP A 322 ? 0.34481 0.22870 0.29180 -0.09350 0.06224  -0.03786 316 ASP A CB  
2600 C CG  . ASP A 322 ? 0.35634 0.26351 0.32823 -0.13405 0.07751  -0.05141 316 ASP A CG  
2601 O OD1 . ASP A 322 ? 0.36717 0.25681 0.31975 -0.14942 0.09072  -0.03490 316 ASP A OD1 
2602 O OD2 . ASP A 322 ? 0.31468 0.29120 0.35341 -0.15861 0.10138  -0.07702 316 ASP A OD2 
2603 N N   . PRO A 323 ? 0.29827 0.20590 0.25286 0.00247  0.05150  0.04483  317 PRO A N   
2604 C CA  . PRO A 323 ? 0.27572 0.19800 0.25413 0.01617  0.01950  0.02709  317 PRO A CA  
2605 C C   . PRO A 323 ? 0.27719 0.20476 0.26638 0.01575  0.01641  0.03238  317 PRO A C   
2606 O O   . PRO A 323 ? 0.28558 0.20433 0.28211 -0.02632 0.02822  0.01690  317 PRO A O   
2607 C CB  . PRO A 323 ? 0.32857 0.25694 0.30166 0.04237  0.03500  0.03916  317 PRO A CB  
2608 C CG  . PRO A 323 ? 0.34863 0.29286 0.30709 0.02728  0.06005  0.03138  317 PRO A CG  
2609 C CD  . PRO A 323 ? 0.29818 0.26856 0.25488 0.01222  0.01116  0.04488  317 PRO A CD  
2610 N N   . SER A 324 ? 0.25582 0.18316 0.28672 0.01931  0.00942  0.00221  318 SER A N   
2611 C CA  . SER A 324 ? 0.26191 0.19149 0.28821 -0.00761 0.02370  0.00538  318 SER A CA  
2612 C C   . SER A 324 ? 0.27103 0.19462 0.29685 -0.02083 0.04321  0.01307  318 SER A C   
2613 O O   . SER A 324 ? 0.29862 0.20395 0.29726 -0.01833 0.01833  0.01649  318 SER A O   
2614 C CB  A SER A 324 ? 0.23717 0.21369 0.30954 0.01286  0.02963  0.00996  318 SER A CB  
2615 C CB  B SER A 324 ? 0.19719 0.19997 0.27812 -0.02128 0.03939  0.00636  318 SER A CB  
2616 O OG  A SER A 324 ? 0.26198 0.22341 0.31559 0.02346  0.02181  -0.02233 318 SER A OG  
2617 O OG  B SER A 324 ? 0.16350 0.20126 0.25051 -0.04216 0.03061  -0.02091 318 SER A OG  
2618 N N   . ASP A 325 ? 0.24244 0.16298 0.29614 -0.01721 0.05505  0.02766  319 ASP A N   
2619 C CA  . ASP A 325 ? 0.19159 0.18341 0.28850 -0.02098 0.01844  0.04207  319 ASP A CA  
2620 C C   . ASP A 325 ? 0.20378 0.18260 0.22709 -0.02633 0.02378  0.03657  319 ASP A C   
2621 O O   . ASP A 325 ? 0.20003 0.18782 0.25669 -0.01197 0.02098  0.02116  319 ASP A O   
2622 C CB  . ASP A 325 ? 0.20230 0.22090 0.35594 -0.00906 0.05964  0.05794  319 ASP A CB  
2623 C CG  . ASP A 325 ? 0.23359 0.25898 0.41160 -0.00555 0.05247  0.01855  319 ASP A CG  
2624 O OD1 . ASP A 325 ? 0.26449 0.27358 0.43271 -0.00381 0.02999  -0.03225 319 ASP A OD1 
2625 O OD2 . ASP A 325 ? 0.21347 0.28301 0.43605 0.00203  0.02846  0.03211  319 ASP A OD2 
2626 N N   . GLU A 326 ? 0.21105 0.16230 0.20857 -0.03316 0.03721  0.01478  320 GLU A N   
2627 C CA  . GLU A 326 ? 0.22847 0.19992 0.19311 -0.02535 0.01476  0.00541  320 GLU A CA  
2628 C C   . GLU A 326 ? 0.25792 0.19003 0.20558 0.00145  0.03649  0.02349  320 GLU A C   
2629 O O   . GLU A 326 ? 0.26661 0.17762 0.24982 -0.00597 0.07763  0.03031  320 GLU A O   
2630 C CB  . GLU A 326 ? 0.22990 0.21348 0.20287 -0.01193 0.02289  -0.00430 320 GLU A CB  
2631 C CG  . GLU A 326 ? 0.22045 0.22450 0.19677 -0.01544 0.03439  0.01345  320 GLU A CG  
2632 C CD  . GLU A 326 ? 0.25359 0.20855 0.24360 -0.01505 0.05286  0.02201  320 GLU A CD  
2633 O OE1 . GLU A 326 ? 0.26092 0.19733 0.24571 0.00022  0.03304  0.03208  320 GLU A OE1 
2634 O OE2 . GLU A 326 ? 0.22972 0.20620 0.26787 -0.02077 0.02237  0.01715  320 GLU A OE2 
2635 N N   . PRO A 327 ? 0.27433 0.17845 0.20247 0.00919  0.01802  0.02322  321 PRO A N   
2636 C CA  . PRO A 327 ? 0.24600 0.20310 0.19720 -0.02314 0.01874  0.00673  321 PRO A CA  
2637 C C   . PRO A 327 ? 0.27883 0.20772 0.21678 -0.02257 0.05464  -0.00059 321 PRO A C   
2638 O O   . PRO A 327 ? 0.28776 0.21585 0.22899 -0.03308 0.05171  -0.01190 321 PRO A O   
2639 C CB  . PRO A 327 ? 0.29158 0.22805 0.21419 0.01239  0.00906  0.00738  321 PRO A CB  
2640 C CG  . PRO A 327 ? 0.29093 0.22971 0.22334 0.02008  0.04849  0.02802  321 PRO A CG  
2641 C CD  . PRO A 327 ? 0.25978 0.21479 0.18990 0.01340  0.01325  0.04868  321 PRO A CD  
2642 N N   . ILE A 328 ? 0.22803 0.21833 0.21939 -0.00131 0.06584  -0.00475 322 ILE A N   
2643 C CA  . ILE A 328 ? 0.23664 0.21386 0.20874 -0.02281 0.04129  -0.04211 322 ILE A CA  
2644 C C   . ILE A 328 ? 0.26613 0.20951 0.22356 -0.03354 0.02259  -0.01729 322 ILE A C   
2645 O O   . ILE A 328 ? 0.30713 0.22740 0.23358 -0.01911 0.04374  -0.01175 322 ILE A O   
2646 C CB  . ILE A 328 ? 0.24906 0.20743 0.19696 0.00039  0.02824  -0.04005 322 ILE A CB  
2647 C CG1 . ILE A 328 ? 0.25923 0.22056 0.24214 0.03338  0.00720  -0.00971 322 ILE A CG1 
2648 C CG2 . ILE A 328 ? 0.30715 0.24255 0.20364 -0.03177 0.04182  -0.04631 322 ILE A CG2 
2649 C CD1 . ILE A 328 ? 0.30244 0.24302 0.28441 0.00439  0.01101  -0.02081 322 ILE A CD1 
2650 N N   . ALA A 329 ? 0.26284 0.20163 0.23150 -0.04407 0.00069  -0.00129 323 ALA A N   
2651 C CA  . ALA A 329 ? 0.31298 0.20224 0.23945 -0.06077 0.02214  -0.00957 323 ALA A CA  
2652 C C   . ALA A 329 ? 0.39061 0.23459 0.26371 -0.04746 0.02671  -0.01814 323 ALA A C   
2653 O O   . ALA A 329 ? 0.38132 0.24335 0.29977 -0.03996 0.03223  -0.02986 323 ALA A O   
2654 C CB  . ALA A 329 ? 0.31365 0.22186 0.23188 -0.07100 -0.00236 -0.00586 323 ALA A CB  
2655 N N   . GLU A 330 ? 0.47789 0.27048 0.25499 -0.05829 0.05261  -0.03005 324 GLU A N   
2656 C CA  . GLU A 330 ? 0.55913 0.31686 0.32946 -0.05280 0.10293  -0.04850 324 GLU A CA  
2657 C C   . GLU A 330 ? 0.61128 0.33468 0.40197 -0.05006 0.18255  -0.09314 324 GLU A C   
2658 O O   . GLU A 330 ? 0.65713 0.34754 0.44130 -0.05444 0.21403  -0.10964 324 GLU A O   
2659 C CB  . GLU A 330 ? 0.60681 0.35957 0.37057 -0.04733 0.08872  -0.05779 324 GLU A CB  
2660 C CG  . GLU A 330 ? 0.62679 0.37862 0.39473 -0.04164 0.08322  -0.04355 324 GLU A CG  
2661 C CD  . GLU A 330 ? 0.64186 0.39708 0.41949 -0.04030 0.08709  -0.03356 324 GLU A CD  
2662 O OE1 . GLU A 330 ? 0.64435 0.40063 0.42480 -0.03914 0.08323  -0.03982 324 GLU A OE1 
2663 O OE2 . GLU A 330 ? 0.65841 0.41244 0.44023 -0.04208 0.09789  -0.01555 324 GLU A OE2 
2664 N N   . ALA A 331 ? 0.61083 0.35360 0.43379 -0.04196 0.24073  -0.08380 325 ALA A N   
2665 C CA  . ALA A 331 ? 0.61461 0.38167 0.45427 -0.02336 0.21019  -0.08236 325 ALA A CA  
2666 C C   . ALA A 331 ? 0.58669 0.39248 0.44025 0.00094  0.12880  -0.07526 325 ALA A C   
2667 O O   . ALA A 331 ? 0.61263 0.39900 0.44584 0.02190  0.14074  -0.03785 325 ALA A O   
2668 C CB  . ALA A 331 ? 0.63975 0.39806 0.43443 -0.04536 0.21863  -0.09619 325 ALA A CB  
2669 N N   . PRO A 332 ? 0.58765 0.40016 0.45947 0.00554  0.08397  -0.05739 326 PRO A N   
2670 C CA  . PRO A 332 ? 0.53950 0.38664 0.41698 -0.00351 0.05667  -0.09423 326 PRO A CA  
2671 C C   . PRO A 332 ? 0.45387 0.39928 0.33158 -0.00304 0.07142  -0.10930 326 PRO A C   
2672 O O   . PRO A 332 ? 0.45341 0.38861 0.32277 -0.04536 0.10119  -0.10059 326 PRO A O   
2673 C CB  . PRO A 332 ? 0.58431 0.38831 0.45849 -0.00144 0.05735  -0.08544 326 PRO A CB  
2674 C CG  . PRO A 332 ? 0.59389 0.41091 0.50267 0.00405  0.06174  -0.06506 326 PRO A CG  
2675 C CD  . PRO A 332 ? 0.60629 0.41495 0.48873 0.00627  0.07227  -0.06540 326 PRO A CD  
2676 N N   A PHE A 333 ? 0.45929 0.41364 0.31834 0.01971  0.05474  -0.11468 327 PHE A N   
2677 N N   B PHE A 333 ? 0.40867 0.40563 0.31800 0.02986  0.07790  -0.10394 327 PHE A N   
2678 C CA  A PHE A 333 ? 0.54644 0.44622 0.32667 0.03360  0.06805  -0.14807 327 PHE A CA  
2679 C CA  B PHE A 333 ? 0.45873 0.43252 0.33657 0.05118  0.10972  -0.13111 327 PHE A CA  
2680 C C   A PHE A 333 ? 0.58766 0.46758 0.39074 0.02430  0.09936  -0.14696 327 PHE A C   
2681 C C   B PHE A 333 ? 0.46089 0.45814 0.38884 0.01743  0.14554  -0.12650 327 PHE A C   
2682 O O   A PHE A 333 ? 0.61437 0.47163 0.41612 0.02998  0.14526  -0.15481 327 PHE A O   
2683 O O   B PHE A 333 ? 0.49393 0.46224 0.41034 -0.00832 0.19776  -0.13833 327 PHE A O   
2684 C CB  A PHE A 333 ? 0.60844 0.45798 0.33288 0.01818  0.05353  -0.16268 327 PHE A CB  
2685 C CB  B PHE A 333 ? 0.48741 0.44749 0.35418 0.09237  0.09567  -0.12818 327 PHE A CB  
2686 C CG  A PHE A 333 ? 0.61746 0.46480 0.31093 0.00387  0.01677  -0.18263 327 PHE A CG  
2687 C CG  B PHE A 333 ? 0.47171 0.46345 0.33328 0.12115  0.05555  -0.13077 327 PHE A CG  
2688 C CD1 A PHE A 333 ? 0.62412 0.47919 0.33019 0.01274  0.02216  -0.17083 327 PHE A CD1 
2689 C CD1 B PHE A 333 ? 0.45729 0.47224 0.36130 0.14302  0.06888  -0.10844 327 PHE A CD1 
2690 C CD2 A PHE A 333 ? 0.62157 0.46194 0.31350 0.00135  0.02163  -0.19233 327 PHE A CD2 
2691 C CD2 B PHE A 333 ? 0.44605 0.46992 0.33658 0.13772  0.05778  -0.13651 327 PHE A CD2 
2692 C CE1 A PHE A 333 ? 0.62992 0.48052 0.30223 0.00838  0.00266  -0.18105 327 PHE A CE1 
2693 C CE1 B PHE A 333 ? 0.44797 0.47504 0.36063 0.16286  0.05130  -0.10322 327 PHE A CE1 
2694 C CE2 A PHE A 333 ? 0.62882 0.47463 0.31309 0.00723  0.01346  -0.18416 327 PHE A CE2 
2695 C CE2 B PHE A 333 ? 0.43329 0.47145 0.33942 0.15110  0.06497  -0.12027 327 PHE A CE2 
2696 C CZ  A PHE A 333 ? 0.63068 0.48149 0.31741 0.00938  0.01540  -0.17244 327 PHE A CZ  
2697 C CZ  B PHE A 333 ? 0.45172 0.47433 0.34840 0.15794  0.05877  -0.11277 327 PHE A CZ  
2698 N N   . ASP A 340 ? 0.66439 0.87865 0.78934 0.05242  -0.08871 0.13454  334 ASP A N   
2699 C CA  . ASP A 340 ? 0.64122 0.88689 0.79041 0.03761  -0.12053 0.11120  334 ASP A CA  
2700 C C   . ASP A 340 ? 0.60550 0.89281 0.78939 0.01787  -0.14749 0.09366  334 ASP A C   
2701 O O   . ASP A 340 ? 0.59182 0.90241 0.79012 0.01538  -0.17412 0.08548  334 ASP A O   
2702 C CB  . ASP A 340 ? 0.66586 0.88568 0.80709 0.03289  -0.10466 0.09829  334 ASP A CB  
2703 C CG  . ASP A 340 ? 0.66310 0.88542 0.81737 0.04101  -0.11249 0.09773  334 ASP A CG  
2704 O OD1 . ASP A 340 ? 0.63161 0.88286 0.81786 0.04862  -0.14080 0.09864  334 ASP A OD1 
2705 O OD2 . ASP A 340 ? 0.67286 0.88855 0.81860 0.04227  -0.11118 0.09667  334 ASP A OD2 
2706 N N   . ASP A 341 ? 0.59280 0.88636 0.77588 0.00530  -0.13340 0.09440  335 ASP A N   
2707 C CA  . ASP A 341 ? 0.57695 0.88628 0.75582 0.01004  -0.13428 0.10012  335 ASP A CA  
2708 C C   . ASP A 341 ? 0.53846 0.89335 0.74263 0.00073  -0.15042 0.11025  335 ASP A C   
2709 O O   . ASP A 341 ? 0.52759 0.89183 0.73266 0.00129  -0.17348 0.11204  335 ASP A O   
2710 C CB  . ASP A 341 ? 0.55939 0.87839 0.74950 0.03388  -0.14833 0.10031  335 ASP A CB  
2711 C CG  . ASP A 341 ? 0.55997 0.87544 0.75720 0.03398  -0.14301 0.09310  335 ASP A CG  
2712 O OD1 . ASP A 341 ? 0.58361 0.87690 0.77350 0.03220  -0.12119 0.08069  335 ASP A OD1 
2713 O OD2 . ASP A 341 ? 0.51546 0.87294 0.73895 0.04479  -0.19242 0.10350  335 ASP A OD2 
2714 N N   . LEU A 342 ? 0.51110 0.90325 0.74075 -0.00369 -0.13868 0.12090  336 LEU A N   
2715 C CA  . LEU A 342 ? 0.49152 0.91521 0.75919 -0.02278 -0.10717 0.12270  336 LEU A CA  
2716 C C   . LEU A 342 ? 0.40260 0.92884 0.74902 -0.04063 -0.13416 0.13635  336 LEU A C   
2717 O O   . LEU A 342 ? 0.34265 0.93477 0.75604 -0.04855 -0.20672 0.12187  336 LEU A O   
2718 C CB  . LEU A 342 ? 0.55400 0.91719 0.76119 -0.00483 -0.09578 0.11981  336 LEU A CB  
2719 C CG  . LEU A 342 ? 0.60390 0.91402 0.75616 0.00219  -0.08475 0.11850  336 LEU A CG  
2720 C CD1 . LEU A 342 ? 0.61937 0.91575 0.75353 0.00495  -0.07152 0.11724  336 LEU A CD1 
2721 C CD2 . LEU A 342 ? 0.61028 0.91615 0.75749 -0.00280 -0.08783 0.10852  336 LEU A CD2 
2722 N N   . PRO A 343 ? 0.40747 0.92559 0.72699 -0.04004 -0.08162 0.16559  337 PRO A N   
2723 C CA  . PRO A 343 ? 0.38713 0.91926 0.70651 -0.06978 -0.05431 0.18431  337 PRO A CA  
2724 C C   . PRO A 343 ? 0.35195 0.91052 0.66116 -0.08496 -0.07248 0.22239  337 PRO A C   
2725 O O   . PRO A 343 ? 0.35148 0.92519 0.66982 -0.07592 -0.04424 0.22793  337 PRO A O   
2726 C CB  . PRO A 343 ? 0.41888 0.91809 0.73875 -0.07310 -0.01515 0.16979  337 PRO A CB  
2727 C CG  . PRO A 343 ? 0.41936 0.91810 0.74631 -0.04393 -0.01135 0.17328  337 PRO A CG  
2728 C CD  . PRO A 343 ? 0.42958 0.92260 0.72912 -0.03357 -0.03755 0.17605  337 PRO A CD  
2729 N N   . LYS A 344 ? 0.33166 0.89772 0.62222 -0.11104 -0.07070 0.26311  338 LYS A N   
2730 C CA  . LYS A 344 ? 0.34740 0.88537 0.63289 -0.15324 0.00031  0.27152  338 LYS A CA  
2731 C C   . LYS A 344 ? 0.36986 0.89868 0.64519 -0.15512 0.04337  0.26977  338 LYS A C   
2732 O O   . LYS A 344 ? 0.33846 0.89118 0.66479 -0.14994 0.03730  0.25636  338 LYS A O   
2733 C CB  . LYS A 344 ? 0.36439 0.84957 0.63041 -0.16272 0.02391  0.29037  338 LYS A CB  
2734 C CG  . LYS A 344 ? 0.38226 0.81734 0.62039 -0.16579 0.03375  0.29134  338 LYS A CG  
2735 C CD  . LYS A 344 ? 0.39289 0.79868 0.61330 -0.17891 0.02261  0.29192  338 LYS A CD  
2736 C CE  . LYS A 344 ? 0.43007 0.79476 0.60767 -0.16583 0.01121  0.29791  338 LYS A CE  
2737 N NZ  . LYS A 344 ? 0.44054 0.78752 0.60082 -0.16422 0.01652  0.30677  338 LYS A NZ  
2738 N N   . GLU A 345 ? 0.40080 0.89388 0.60750 -0.15285 0.05921  0.27292  339 GLU A N   
2739 C CA  . GLU A 345 ? 0.43817 0.88190 0.60695 -0.13379 0.09771  0.26013  339 GLU A CA  
2740 C C   . GLU A 345 ? 0.40657 0.87518 0.56741 -0.11418 0.12376  0.24590  339 GLU A C   
2741 O O   . GLU A 345 ? 0.39634 0.86580 0.57073 -0.10402 0.12683  0.24427  339 GLU A O   
2742 C CB  . GLU A 345 ? 0.45561 0.86459 0.62551 -0.14674 0.07235  0.26349  339 GLU A CB  
2743 C CG  . GLU A 345 ? 0.47302 0.85540 0.64451 -0.15091 0.05254  0.26202  339 GLU A CG  
2744 C CD  . GLU A 345 ? 0.48265 0.85757 0.68233 -0.13975 0.05497  0.25289  339 GLU A CD  
2745 O OE1 . GLU A 345 ? 0.44648 0.85533 0.68104 -0.13838 0.01133  0.23927  339 GLU A OE1 
2746 O OE2 . GLU A 345 ? 0.51797 0.86473 0.71571 -0.12584 0.09501  0.26020  339 GLU A OE2 
2747 N N   . LYS A 346 ? 0.36960 0.86967 0.50767 -0.07693 0.10922  0.23743  340 LYS A N   
2748 C CA  . LYS A 346 ? 0.33165 0.87664 0.48971 -0.04066 0.09104  0.22058  340 LYS A CA  
2749 C C   . LYS A 346 ? 0.29915 0.88698 0.48269 -0.04430 0.04900  0.22237  340 LYS A C   
2750 O O   . LYS A 346 ? 0.31419 0.88740 0.48617 -0.04113 0.01387  0.21219  340 LYS A O   
2751 C CB  . LYS A 346 ? 0.28795 0.86055 0.46745 -0.00302 0.06656  0.20503  340 LYS A CB  
2752 C CG  . LYS A 346 ? 0.35115 0.84889 0.45582 0.01562  0.07946  0.19443  340 LYS A CG  
2753 C CD  . LYS A 346 ? 0.39491 0.84440 0.44082 0.03683  0.08640  0.18233  340 LYS A CD  
2754 C CE  . LYS A 346 ? 0.43965 0.84490 0.44716 0.05275  0.12230  0.16295  340 LYS A CE  
2755 N NZ  . LYS A 346 ? 0.48563 0.84686 0.44848 0.06708  0.16929  0.14978  340 LYS A NZ  
2756 N N   . LEU A 347 ? 0.25036 0.88720 0.45344 -0.03814 -0.00271 0.22951  341 LEU A N   
2757 C CA  . LEU A 347 ? 0.23919 0.84644 0.42662 -0.03101 -0.03034 0.21163  341 LEU A CA  
2758 C C   . LEU A 347 ? 0.23742 0.84255 0.38271 -0.05020 -0.02271 0.21409  341 LEU A C   
2759 O O   . LEU A 347 ? 0.25454 0.85011 0.37031 -0.04594 0.02395  0.19926  341 LEU A O   
2760 C CB  . LEU A 347 ? 0.25219 0.83982 0.44584 -0.01342 -0.05617 0.20870  341 LEU A CB  
2761 C CG  . LEU A 347 ? 0.29403 0.87041 0.47993 0.02073  -0.05230 0.23487  341 LEU A CG  
2762 C CD1 . LEU A 347 ? 0.30772 0.87342 0.49101 0.03136  -0.04458 0.23131  341 LEU A CD1 
2763 C CD2 . LEU A 347 ? 0.33377 0.86808 0.49666 0.03194  -0.01050 0.24765  341 LEU A CD2 
2764 N N   . LYS A 348 ? 0.23818 0.83684 0.37811 -0.06345 -0.02633 0.20867  342 LYS A N   
2765 C CA  . LYS A 348 ? 0.26511 0.81625 0.36012 -0.07719 -0.03746 0.21111  342 LYS A CA  
2766 C C   . LYS A 348 ? 0.28358 0.81603 0.34779 -0.02080 0.02436  0.18284  342 LYS A C   
2767 O O   . LYS A 348 ? 0.26107 0.80217 0.31503 0.00432  0.00386  0.19093  342 LYS A O   
2768 C CB  . LYS A 348 ? 0.26981 0.78538 0.33800 -0.14643 -0.06481 0.22172  342 LYS A CB  
2769 C CG  . LYS A 348 ? 0.28752 0.73301 0.33039 -0.16090 -0.08830 0.19837  342 LYS A CG  
2770 C CD  . LYS A 348 ? 0.32003 0.73055 0.34235 -0.18937 -0.08588 0.20049  342 LYS A CD  
2771 C CE  . LYS A 348 ? 0.34318 0.69866 0.34554 -0.21685 -0.06611 0.19907  342 LYS A CE  
2772 N NZ  . LYS A 348 ? 0.39873 0.67729 0.37271 -0.20384 -0.03297 0.19986  342 LYS A NZ  
2773 N N   . GLU A 349 ? 0.29732 0.82654 0.38012 0.01607  0.08185  0.16221  343 GLU A N   
2774 C CA  . GLU A 349 ? 0.31584 0.82728 0.38727 0.04915  0.10794  0.12126  343 GLU A CA  
2775 C C   . GLU A 349 ? 0.28800 0.82270 0.38081 0.08631  0.06635  0.11534  343 GLU A C   
2776 O O   . GLU A 349 ? 0.30055 0.83289 0.39353 0.14674  0.06713  0.12031  343 GLU A O   
2777 C CB  . GLU A 349 ? 0.34791 0.83964 0.43744 0.06821  0.10167  0.08589  343 GLU A CB  
2778 C CG  . GLU A 349 ? 0.39079 0.84623 0.46388 0.07709  0.12533  0.06220  343 GLU A CG  
2779 C CD  . GLU A 349 ? 0.43873 0.85195 0.49474 0.06866  0.13877  0.03634  343 GLU A CD  
2780 O OE1 . GLU A 349 ? 0.47323 0.85587 0.50940 0.06257  0.12907  0.03089  343 GLU A OE1 
2781 O OE2 . GLU A 349 ? 0.45273 0.85665 0.50732 0.06734  0.15780  0.01950  343 GLU A OE2 
2782 N N   . LEU A 350 ? 0.23824 0.80458 0.37099 0.08465  0.03039  0.09647  344 LEU A N   
2783 C CA  . LEU A 350 ? 0.25675 0.76971 0.38608 0.10309  0.02232  0.10275  344 LEU A CA  
2784 C C   . LEU A 350 ? 0.26263 0.70873 0.34061 0.11086  0.02828  0.10256  344 LEU A C   
2785 O O   . LEU A 350 ? 0.28078 0.69925 0.29752 0.11850  0.02089  0.11448  344 LEU A O   
2786 C CB  . LEU A 350 ? 0.28062 0.79355 0.40951 0.13225  0.05281  0.11425  344 LEU A CB  
2787 C CG  . LEU A 350 ? 0.28612 0.81017 0.44824 0.15515  0.05633  0.11723  344 LEU A CG  
2788 C CD1 . LEU A 350 ? 0.29421 0.82164 0.45750 0.15373  0.03696  0.12838  344 LEU A CD1 
2789 C CD2 . LEU A 350 ? 0.30518 0.81208 0.47877 0.18488  0.07614  0.11445  344 LEU A CD2 
2790 N N   . ILE A 351 ? 0.25976 0.65477 0.32836 0.10162  0.00915  0.12180  345 ILE A N   
2791 C CA  . ILE A 351 ? 0.23014 0.59173 0.28217 0.06638  0.02494  0.11477  345 ILE A CA  
2792 C C   . ILE A 351 ? 0.26806 0.55141 0.25214 0.06975  0.03632  0.12282  345 ILE A C   
2793 O O   . ILE A 351 ? 0.29947 0.52465 0.25703 0.09217  0.04882  0.14423  345 ILE A O   
2794 C CB  . ILE A 351 ? 0.21053 0.57352 0.25678 0.02168  -0.00116 0.10596  345 ILE A CB  
2795 C CG1 . ILE A 351 ? 0.24485 0.56662 0.28529 0.00304  0.00483  0.12398  345 ILE A CG1 
2796 C CG2 . ILE A 351 ? 0.18422 0.54776 0.24429 0.00798  -0.00927 0.12332  345 ILE A CG2 
2797 C CD1 . ILE A 351 ? 0.25844 0.56287 0.31701 -0.03293 0.03713  0.13681  345 ILE A CD1 
2798 N N   . PHE A 352 ? 0.29741 0.54564 0.25571 0.05068  0.03927  0.10104  346 PHE A N   
2799 C CA  . PHE A 352 ? 0.31397 0.53316 0.25054 0.06796  0.02259  0.06992  346 PHE A CA  
2800 C C   . PHE A 352 ? 0.31941 0.52779 0.24549 0.11875  -0.00725 0.06529  346 PHE A C   
2801 O O   . PHE A 352 ? 0.36269 0.50963 0.23456 0.12492  -0.01708 0.06019  346 PHE A O   
2802 C CB  . PHE A 352 ? 0.30655 0.52364 0.25327 0.07501  -0.00184 0.08411  346 PHE A CB  
2803 C CG  . PHE A 352 ? 0.30384 0.51775 0.24671 0.07680  -0.01304 0.07181  346 PHE A CG  
2804 C CD1 . PHE A 352 ? 0.26040 0.51373 0.27406 0.04653  -0.00473 0.07168  346 PHE A CD1 
2805 C CD2 . PHE A 352 ? 0.31022 0.52912 0.24959 0.06174  0.00806  0.07751  346 PHE A CD2 
2806 C CE1 . PHE A 352 ? 0.27996 0.50131 0.24861 0.06238  0.00017  0.07739  346 PHE A CE1 
2807 C CE2 . PHE A 352 ? 0.28787 0.51700 0.25226 0.05780  0.00377  0.08242  346 PHE A CE2 
2808 C CZ  . PHE A 352 ? 0.30109 0.50949 0.26247 0.05370  0.01003  0.07637  346 PHE A CZ  
2809 N N   . GLU A 353 ? 0.30164 0.53861 0.25400 0.13706  -0.03566 0.06105  347 GLU A N   
2810 C CA  . GLU A 353 ? 0.33494 0.52364 0.30456 0.15159  -0.01410 0.04333  347 GLU A CA  
2811 C C   . GLU A 353 ? 0.37903 0.48994 0.31160 0.14202  -0.01116 0.02991  347 GLU A C   
2812 O O   . GLU A 353 ? 0.42620 0.47601 0.33424 0.15209  0.01952  0.02716  347 GLU A O   
2813 C CB  . GLU A 353 ? 0.37082 0.54660 0.37373 0.17425  0.00939  0.04910  347 GLU A CB  
2814 C CG  . GLU A 353 ? 0.38377 0.56138 0.41732 0.17798  0.03405  0.02959  347 GLU A CG  
2815 C CD  . GLU A 353 ? 0.40841 0.57288 0.43083 0.17046  0.04935  0.02567  347 GLU A CD  
2816 O OE1 . GLU A 353 ? 0.42299 0.58479 0.44900 0.15518  0.07570  0.00738  347 GLU A OE1 
2817 O OE2 . GLU A 353 ? 0.42046 0.57316 0.43410 0.17801  0.04700  0.03403  347 GLU A OE2 
2818 N N   . GLU A 354 ? 0.38114 0.46937 0.28016 0.11085  -0.01032 0.04438  348 GLU A N   
2819 C CA  . GLU A 354 ? 0.40347 0.44557 0.30018 0.09254  0.02201  0.04021  348 GLU A CA  
2820 C C   . GLU A 354 ? 0.36253 0.39613 0.29460 0.08562  0.01104  0.06694  348 GLU A C   
2821 O O   . GLU A 354 ? 0.39516 0.40373 0.33749 0.08331  -0.03021 0.04973  348 GLU A O   
2822 C CB  . GLU A 354 ? 0.43284 0.46965 0.31686 0.10476  0.00727  0.06076  348 GLU A CB  
2823 C CG  . GLU A 354 ? 0.46136 0.48894 0.34844 0.11039  0.01921  0.04630  348 GLU A CG  
2824 C CD  . GLU A 354 ? 0.48531 0.51534 0.38754 0.12000  0.01527  0.03590  348 GLU A CD  
2825 O OE1 . GLU A 354 ? 0.52958 0.55030 0.43024 0.11193  0.05013  0.01643  348 GLU A OE1 
2826 O OE2 . GLU A 354 ? 0.50551 0.50341 0.39839 0.12528  0.00071  0.03030  348 GLU A OE2 
2827 N N   . THR A 355 ? 0.31189 0.33980 0.27029 0.10002  0.00048  0.08079  349 THR A N   
2828 C CA  . THR A 355 ? 0.30934 0.30958 0.29180 0.04872  -0.01692 0.05339  349 THR A CA  
2829 C C   . THR A 355 ? 0.33138 0.30533 0.30325 0.05179  0.00418  0.03454  349 THR A C   
2830 O O   . THR A 355 ? 0.29412 0.29636 0.30906 0.01951  0.00515  -0.00392 349 THR A O   
2831 C CB  . THR A 355 ? 0.30370 0.30590 0.28004 0.03423  -0.02940 0.05137  349 THR A CB  
2832 O OG1 . THR A 355 ? 0.32248 0.30608 0.28599 0.03501  0.03674  0.04831  349 THR A OG1 
2833 C CG2 . THR A 355 ? 0.31034 0.31878 0.26558 0.01540  -0.07164 0.05014  349 THR A CG2 
2834 N N   . ALA A 356 ? 0.39056 0.31065 0.31329 0.03108  0.02069  0.02363  350 ALA A N   
2835 C CA  . ALA A 356 ? 0.41519 0.34561 0.35026 0.02194  0.02816  -0.00718 350 ALA A CA  
2836 C C   . ALA A 356 ? 0.45570 0.35910 0.35064 0.00536  0.02773  -0.01104 350 ALA A C   
2837 O O   . ALA A 356 ? 0.43343 0.37346 0.33340 -0.03741 0.00755  -0.03183 350 ALA A O   
2838 C CB  . ALA A 356 ? 0.39432 0.36320 0.38632 0.07449  0.00885  -0.00717 350 ALA A CB  
2839 N N   . ARG A 357 ? 0.48968 0.34858 0.36181 0.01978  -0.01154 0.02272  351 ARG A N   
2840 C CA  . ARG A 357 ? 0.51915 0.34652 0.36186 0.02826  -0.02696 0.03011  351 ARG A CA  
2841 C C   . ARG A 357 ? 0.51447 0.33906 0.36172 0.01844  -0.02410 0.01488  351 ARG A C   
2842 O O   . ARG A 357 ? 0.53215 0.35557 0.38284 0.01175  -0.03099 -0.01233 351 ARG A O   
2843 C CB  . ARG A 357 ? 0.54763 0.33991 0.33205 0.03262  -0.04149 0.02369  351 ARG A CB  
2844 C CG  . ARG A 357 ? 0.56181 0.35763 0.32553 0.05637  -0.07218 0.03389  351 ARG A CG  
2845 C CD  . ARG A 357 ? 0.58359 0.38940 0.33628 0.06980  -0.08751 0.01344  351 ARG A CD  
2846 N NE  . ARG A 357 ? 0.59791 0.39965 0.34612 0.07994  -0.10782 0.00207  351 ARG A NE  
2847 C CZ  . ARG A 357 ? 0.60318 0.40301 0.34337 0.08441  -0.10931 -0.02737 351 ARG A CZ  
2848 N NH1 . ARG A 357 ? 0.61141 0.40220 0.34227 0.08144  -0.11213 -0.03246 351 ARG A NH1 
2849 N NH2 . ARG A 357 ? 0.60184 0.40808 0.34936 0.09296  -0.10124 -0.05373 351 ARG A NH2 
2850 N N   . PHE A 358 ? 0.46764 0.30224 0.29216 0.02159  -0.04886 0.03020  352 PHE A N   
2851 C CA  . PHE A 358 ? 0.44247 0.31362 0.26897 -0.00865 -0.04833 0.01097  352 PHE A CA  
2852 C C   . PHE A 358 ? 0.42495 0.35088 0.30169 -0.02448 -0.07027 -0.00224 352 PHE A C   
2853 O O   . PHE A 358 ? 0.37080 0.36687 0.32330 -0.00620 -0.05537 0.02732  352 PHE A O   
2854 C CB  . PHE A 358 ? 0.40773 0.30954 0.22123 -0.02242 -0.06979 -0.02710 352 PHE A CB  
2855 C CG  . PHE A 358 ? 0.40187 0.32616 0.26212 -0.01757 -0.07259 -0.01176 352 PHE A CG  
2856 C CD1 . PHE A 358 ? 0.40740 0.33140 0.27321 -0.01639 -0.05358 0.00248  352 PHE A CD1 
2857 C CD2 . PHE A 358 ? 0.44474 0.35219 0.28752 -0.01321 -0.05308 0.02340  352 PHE A CD2 
2858 C CE1 . PHE A 358 ? 0.39386 0.34481 0.29982 0.00252  -0.06760 0.04650  352 PHE A CE1 
2859 C CE2 . PHE A 358 ? 0.46460 0.36326 0.34519 -0.03565 0.01324  0.05174  352 PHE A CE2 
2860 C CZ  . PHE A 358 ? 0.42565 0.36331 0.35113 -0.04286 0.00324  0.04015  352 PHE A CZ  
2861 N N   . GLN A 359 ? 0.42301 0.36807 0.28262 -0.05410 -0.09182 -0.00631 353 GLN A N   
2862 C CA  . GLN A 359 ? 0.46809 0.41591 0.37025 -0.07802 -0.06515 -0.01679 353 GLN A CA  
2863 C C   . GLN A 359 ? 0.53952 0.46021 0.48782 -0.12645 -0.11961 -0.01482 353 GLN A C   
2864 O O   . GLN A 359 ? 0.56286 0.48749 0.52889 -0.14669 -0.13446 -0.04761 353 GLN A O   
2865 C CB  . GLN A 359 ? 0.42881 0.41568 0.29263 -0.03916 -0.00912 -0.01867 353 GLN A CB  
2866 C CG  . GLN A 359 ? 0.35043 0.40571 0.22435 -0.01100 -0.05809 -0.01818 353 GLN A CG  
2867 C CD  . GLN A 359 ? 0.37576 0.42248 0.19910 0.03203  -0.04243 0.00581  353 GLN A CD  
2868 O OE1 . GLN A 359 ? 0.40864 0.44771 0.22468 0.08240  -0.06123 -0.00917 353 GLN A OE1 
2869 N NE2 . GLN A 359 ? 0.33977 0.40223 0.16037 0.01541  -0.01424 0.00772  353 GLN A NE2 
2870 N N   . PRO A 360 ? 0.58758 0.49001 0.57180 -0.12733 -0.11897 -0.00284 354 PRO A N   
2871 C CA  . PRO A 360 ? 0.60745 0.50611 0.59451 -0.12826 -0.12917 -0.00854 354 PRO A CA  
2872 C C   . PRO A 360 ? 0.63797 0.51745 0.60783 -0.12254 -0.10649 -0.02137 354 PRO A C   
2873 O O   . PRO A 360 ? 0.67093 0.54515 0.63424 -0.09527 -0.08369 -0.01573 354 PRO A O   
2874 C CB  . PRO A 360 ? 0.61682 0.50884 0.59785 -0.12191 -0.13964 0.00242  354 PRO A CB  
2875 C CG  . PRO A 360 ? 0.60581 0.50468 0.59054 -0.13192 -0.16072 -0.00960 354 PRO A CG  
2876 C CD  . PRO A 360 ? 0.60398 0.49937 0.58651 -0.11662 -0.13086 0.01386  354 PRO A CD  
2877 S S   A SO4 B .   ? 0.41290 0.34176 0.41606 -0.02962 -0.09038 0.10136  401 SO4 A S   
2878 S S   B SO4 B .   ? 0.28204 0.29075 0.29768 -0.07114 -0.00357 0.06428  401 SO4 A S   
2879 O O1  A SO4 B .   ? 0.45251 0.33455 0.41201 -0.04284 -0.08401 0.09817  401 SO4 A O1  
2880 O O1  B SO4 B .   ? 0.26098 0.27894 0.29473 -0.10391 -0.01910 0.03008  401 SO4 A O1  
2881 O O2  A SO4 B .   ? 0.42544 0.34472 0.41162 -0.01739 -0.05132 0.11664  401 SO4 A O2  
2882 O O2  B SO4 B .   ? 0.28288 0.28092 0.24665 -0.09683 -0.00306 0.07645  401 SO4 A O2  
2883 O O3  A SO4 B .   ? 0.38341 0.33563 0.43876 0.00212  -0.10754 0.12839  401 SO4 A O3  
2884 O O3  B SO4 B .   ? 0.33917 0.29497 0.31694 -0.09246 -0.01237 0.05843  401 SO4 A O3  
2885 O O4  A SO4 B .   ? 0.37705 0.33757 0.41096 -0.03017 -0.11984 0.08263  401 SO4 A O4  
2886 O O4  B SO4 B .   ? 0.25362 0.30360 0.29712 -0.04265 -0.04265 0.05848  401 SO4 A O4  
2887 S S   . SO4 C .   ? 0.60979 0.76033 0.77903 -0.09910 -0.13863 -0.01388 402 SO4 A S   
2888 O O1  . SO4 C .   ? 0.58640 0.75835 0.76178 -0.09517 -0.15927 0.00749  402 SO4 A O1  
2889 O O2  . SO4 C .   ? 0.59647 0.75414 0.78697 -0.12224 -0.15647 -0.02681 402 SO4 A O2  
2890 O O3  . SO4 C .   ? 0.62522 0.76255 0.77863 -0.06896 -0.11548 -0.01743 402 SO4 A O3  
2891 O O4  . SO4 C .   ? 0.58149 0.74843 0.75782 -0.13629 -0.17545 -0.03362 402 SO4 A O4  
2892 C C3  . WNT D .   ? 0.27655 0.33136 0.24604 0.03333  -0.02219 0.00806  403 WNT A C3  
2893 C C5  . WNT D .   ? 0.30178 0.33519 0.29548 0.04161  -0.01019 0.01378  403 WNT A C5  
2894 C C6  . WNT D .   ? 0.29950 0.35507 0.28825 0.05019  0.03190  -0.01305 403 WNT A C6  
2895 C C9  . WNT D .   ? 0.30038 0.29218 0.32304 0.01184  -0.09428 0.09516  403 WNT A C9  
2896 C C10 . WNT D .   ? 0.35396 0.28455 0.32923 -0.00182 -0.07540 0.09263  403 WNT A C10 
2897 C C11 . WNT D .   ? 0.35587 0.26008 0.34813 -0.07077 -0.07383 0.09681  403 WNT A C11 
2898 C C8  . WNT D .   ? 0.30992 0.30950 0.30543 0.01431  -0.09221 0.05928  403 WNT A C8  
2899 C C2  . WNT D .   ? 0.29231 0.33411 0.25833 0.06597  -0.01248 -0.02884 403 WNT A C2  
2900 C C7  . WNT D .   ? 0.28701 0.32390 0.28418 0.01853  -0.08737 0.04473  403 WNT A C7  
2901 C C16 . WNT D .   ? 0.25500 0.31082 0.21317 -0.01044 -0.00133 0.06242  403 WNT A C16 
2902 C C15 . WNT D .   ? 0.24824 0.28709 0.21287 -0.02860 -0.04777 0.06832  403 WNT A C15 
2903 C C13 . WNT D .   ? 0.30522 0.24124 0.28745 -0.03999 -0.04105 0.07545  403 WNT A C13 
2904 C C12 . WNT D .   ? 0.35800 0.26760 0.33484 -0.04944 -0.02454 0.11802  403 WNT A C12 
2905 C C18 . WNT D .   ? 0.25117 0.32591 0.23880 0.03888  -0.01735 0.05138  403 WNT A C18 
2906 C C17 . WNT D .   ? 0.28719 0.32848 0.23832 -0.00821 0.01386  0.06627  403 WNT A C17 
2907 C C   . WNT D .   ? 0.30299 0.40480 0.39971 0.07572  0.00829  -0.02672 403 WNT A C   
2908 O O   . WNT D .   ? 0.34642 0.40205 0.38139 0.07365  0.02620  -0.01773 403 WNT A O   
2909 C C1  . WNT D .   ? 0.30703 0.36327 0.29735 0.06805  0.00942  -0.02282 403 WNT A C1  
2910 C C14 . WNT D .   ? 0.23963 0.23466 0.24598 -0.02246 -0.04455 0.07295  403 WNT A C14 
2911 C C4  . WNT D .   ? 0.28898 0.33184 0.25190 0.03244  -0.00836 0.00726  403 WNT A C4  
2912 O O1  . WNT D .   ? 0.26339 0.32629 0.23553 0.00381  -0.02454 0.03059  403 WNT A O1  
2913 O O2  . WNT D .   ? 0.41182 0.28497 0.35094 0.00716  -0.05230 0.06074  403 WNT A O2  
2914 O O3  . WNT D .   ? 0.41238 0.27005 0.40477 -0.08791 -0.07813 0.09018  403 WNT A O3  
2915 O O4  . WNT D .   ? 0.39231 0.29586 0.36588 -0.04766 0.01188  0.11730  403 WNT A O4  
2916 O O5  . WNT D .   ? 0.28402 0.32800 0.24250 0.00738  -0.00392 0.07019  403 WNT A O5  
2917 O O6  . WNT D .   ? 0.23540 0.32358 0.24125 0.01919  -0.01235 0.07627  403 WNT A O6  
2918 O O   . HOH E .   ? 0.33718 0.29517 0.60006 0.00048  -0.07981 -0.14810 501 HOH A O   
2919 O O   . HOH E .   ? 0.68495 0.91839 0.60638 0.12888  0.35840  0.11398  502 HOH A O   
2920 O O   . HOH E .   ? 0.45135 0.89390 0.92035 0.26776  0.06385  -0.08440 503 HOH A O   
2921 O O   . HOH E .   ? 0.56492 0.41748 0.44915 0.11974  -0.02920 -0.12198 504 HOH A O   
2922 O O   . HOH E .   ? 1.01960 0.41199 0.70267 0.07859  0.03086  0.10922  505 HOH A O   
2923 O O   . HOH E .   ? 0.85496 0.31606 0.68890 0.02678  -0.42782 0.00574  506 HOH A O   
2924 O O   . HOH E .   ? 0.59077 0.71877 0.79785 -0.30229 0.06903  0.23566  507 HOH A O   
2925 O O   . HOH E .   ? 0.85646 0.62283 0.61674 -0.14783 0.07454  0.04981  508 HOH A O   
2926 O O   . HOH E .   ? 0.18604 0.41908 0.38692 0.03560  0.02663  -0.05847 509 HOH A O   
2927 O O   . HOH E .   ? 0.34150 0.52140 0.63837 0.04146  0.03068  -0.23958 510 HOH A O   
2928 O O   . HOH E .   ? 0.30358 0.33302 0.35571 0.11732  0.09075  0.04375  511 HOH A O   
2929 O O   . HOH E .   ? 0.42941 0.57498 1.23385 -0.07715 -0.11996 0.41986  512 HOH A O   
2930 O O   . HOH E .   ? 0.82653 0.50358 0.94825 -0.15654 -0.24990 0.31665  513 HOH A O   
2931 O O   . HOH E .   ? 0.67742 0.44203 0.26777 -0.15504 -0.17389 0.05872  514 HOH A O   
2932 O O   . HOH E .   ? 0.75771 0.74637 0.62344 -0.32147 -0.15882 0.20693  515 HOH A O   
2933 O O   . HOH E .   ? 0.67829 0.64343 0.42332 0.15047  0.05352  0.26408  516 HOH A O   
2934 O O   . HOH E .   ? 0.68351 0.50764 0.55784 -0.12407 0.01189  0.26841  517 HOH A O   
2935 O O   . HOH E .   ? 0.81219 0.63791 0.34922 0.25716  0.20248  0.10809  518 HOH A O   
2936 O O   . HOH E .   ? 0.50226 0.30012 0.44706 -0.04079 0.16329  -0.02051 519 HOH A O   
2937 O O   . HOH E .   ? 0.57691 0.95091 0.49432 -0.38422 -0.14924 0.27774  520 HOH A O   
2938 O O   . HOH E .   ? 0.51547 0.46581 0.96322 0.06662  0.17617  0.24283  521 HOH A O   
2939 O O   . HOH E .   ? 0.52195 0.81064 0.34086 -0.03862 -0.08454 0.17418  522 HOH A O   
2940 O O   . HOH E .   ? 1.02545 0.87038 0.54767 -0.19601 -0.14635 0.34646  523 HOH A O   
2941 O O   . HOH E .   ? 0.68232 0.27748 0.47307 0.02404  -0.05648 0.03465  524 HOH A O   
2942 O O   . HOH E .   ? 0.87160 0.97922 0.42204 0.07136  0.05489  -0.12629 525 HOH A O   
2943 O O   . HOH E .   ? 0.38154 0.36055 0.49211 -0.03062 -0.00997 -0.01111 526 HOH A O   
2944 O O   . HOH E .   ? 0.54941 0.85278 0.67581 0.29360  0.04924  0.13729  527 HOH A O   
2945 O O   . HOH E .   ? 0.23158 0.28731 0.22529 0.03571  0.01694  -0.02466 528 HOH A O   
2946 O O   . HOH E .   ? 0.39434 0.23851 0.25758 0.00386  0.01269  0.00976  529 HOH A O   
2947 O O   . HOH E .   ? 0.40231 0.38570 0.45196 -0.08502 -0.01563 0.00422  530 HOH A O   
2948 O O   . HOH E .   ? 0.49144 0.71163 0.91779 0.24203  0.25974  0.34687  531 HOH A O   
2949 O O   . HOH E .   ? 0.46071 0.29639 0.35434 0.01150  0.12275  -0.00467 532 HOH A O   
2950 O O   . HOH E .   ? 0.36524 0.51583 0.32540 0.03441  -0.04599 0.02032  533 HOH A O   
2951 O O   . HOH E .   ? 0.74135 0.34997 0.76825 0.05311  -0.14976 -0.05164 534 HOH A O   
2952 O O   . HOH E .   ? 0.28661 0.34051 0.25201 0.06420  0.01941  -0.00238 535 HOH A O   
2953 O O   . HOH E .   ? 0.59606 0.72431 0.62491 0.03118  -0.18995 0.05313  536 HOH A O   
2954 O O   . HOH E .   ? 0.30564 0.40509 0.21131 -0.02342 0.01424  -0.00315 537 HOH A O   
2955 O O   . HOH E .   ? 0.26245 0.38106 0.59618 0.04234  -0.02805 -0.17161 538 HOH A O   
2956 O O   . HOH E .   ? 0.46085 0.47719 0.54190 0.12468  -0.24016 -0.23972 539 HOH A O   
2957 O O   . HOH E .   ? 0.66027 0.53852 0.71159 -0.16163 -0.19785 0.10279  540 HOH A O   
2958 O O   . HOH E .   ? 0.49883 0.34108 0.36599 -0.04926 0.16524  -0.00347 541 HOH A O   
2959 O O   . HOH E .   ? 0.57534 0.46372 0.35652 0.09590  0.00530  0.05704  542 HOH A O   
2960 O O   . HOH E .   ? 0.65755 0.58017 0.58958 0.14523  0.11725  -0.24582 543 HOH A O   
2961 O O   . HOH E .   ? 1.03912 0.75385 0.54064 0.22691  -0.27686 0.13754  544 HOH A O   
2962 O O   . HOH E .   ? 0.58262 0.42843 0.56012 -0.19381 0.04316  0.16101  545 HOH A O   
2963 O O   . HOH E .   ? 0.27103 0.36894 0.51244 -0.00360 0.03884  -0.06306 546 HOH A O   
2964 O O   . HOH E .   ? 0.72333 0.55154 0.37161 0.19515  0.18159  0.15664  547 HOH A O   
2965 O O   . HOH E .   ? 0.53016 0.49824 0.30988 -0.01241 -0.07335 0.04232  548 HOH A O   
2966 O O   . HOH E .   ? 0.32300 0.56765 0.27999 -0.08362 -0.05776 0.05526  549 HOH A O   
2967 O O   . HOH E .   ? 0.26691 0.27163 0.28050 0.05420  -0.00309 0.08036  550 HOH A O   
2968 O O   . HOH E .   ? 0.30733 0.33090 0.46464 0.04382  0.01598  -0.04488 551 HOH A O   
2969 O O   . HOH E .   ? 0.52208 0.42022 0.35863 -0.14065 -0.12096 0.06757  552 HOH A O   
2970 O O   . HOH E .   ? 0.50029 0.81550 0.99516 0.29163  0.20876  0.00398  553 HOH A O   
2971 O O   . HOH E .   ? 0.40551 0.63127 0.38472 -0.10217 0.06612  0.07120  554 HOH A O   
2972 O O   . HOH E .   ? 0.68839 0.61104 0.70337 0.05118  -0.29538 0.12904  555 HOH A O   
2973 O O   . HOH E .   ? 0.51336 0.42354 0.61176 0.13665  -0.02854 -0.12379 556 HOH A O   
2974 O O   . HOH E .   ? 0.67071 0.73843 0.41787 0.31995  0.00923  0.00198  557 HOH A O   
2975 O O   . HOH E .   ? 0.38462 0.55468 0.76238 -0.04347 0.07030  0.06388  558 HOH A O   
2976 O O   . HOH E .   ? 1.07302 0.32074 0.31519 -0.10706 -0.12011 0.04038  559 HOH A O   
2977 O O   . HOH E .   ? 0.50362 0.38373 0.42904 0.00347  0.02010  0.12872  560 HOH A O   
2978 O O   . HOH E .   ? 0.63847 0.31640 0.75011 -0.00839 -0.01624 0.05646  561 HOH A O   
2979 O O   . HOH E .   ? 0.52220 0.46123 0.71491 0.06463  -0.09159 -0.19016 562 HOH A O   
2980 O O   . HOH E .   ? 0.82984 0.74683 0.55895 0.41391  -0.07267 0.11620  563 HOH A O   
2981 O O   . HOH E .   ? 0.30681 0.30869 0.29330 0.00315  -0.03596 -0.04438 564 HOH A O   
2982 O O   . HOH E .   ? 0.91075 0.78791 0.37861 -0.26638 0.14475  -0.19487 565 HOH A O   
2983 O O   . HOH E .   ? 0.71560 0.29635 0.80742 0.13701  -0.18612 -0.00902 566 HOH A O   
2984 O O   . HOH E .   ? 0.26449 0.85589 0.54820 -0.01443 0.05584  0.21015  567 HOH A O   
2985 O O   . HOH E .   ? 0.42513 0.18010 0.35940 0.04369  -0.06994 0.02633  568 HOH A O   
2986 O O   . HOH E .   ? 0.94788 0.62976 0.36864 -0.16484 0.03989  -0.12729 569 HOH A O   
2987 O O   . HOH E .   ? 0.41825 0.32888 0.50059 -0.00284 -0.04968 0.01590  570 HOH A O   
2988 O O   . HOH E .   ? 0.48721 0.56366 0.68553 0.24859  0.14537  0.26606  571 HOH A O   
2989 O O   . HOH E .   ? 0.42432 0.80545 1.02393 0.29430  -0.00700 0.05667  572 HOH A O   
2990 O O   . HOH E .   ? 0.24570 0.28371 0.29810 -0.00896 -0.01236 -0.04151 573 HOH A O   
2991 O O   . HOH E .   ? 0.30848 0.23301 0.22736 -0.01861 0.07835  0.03892  574 HOH A O   
2992 O O   . HOH E .   ? 0.86371 0.73840 0.65917 -0.12578 -0.22518 0.37278  575 HOH A O   
2993 O O   . HOH E .   ? 0.30816 0.56239 0.97488 -0.00371 -0.00807 0.41100  576 HOH A O   
2994 O O   . HOH E .   ? 0.41534 0.77139 0.80900 0.15156  -0.19110 -0.29915 577 HOH A O   
2995 O O   . HOH E .   ? 0.58797 0.88164 0.38949 0.40965  -0.07193 -0.11744 578 HOH A O   
2996 O O   . HOH E .   ? 0.41051 0.70551 0.60118 0.01849  -0.12149 0.13507  579 HOH A O   
2997 O O   . HOH E .   ? 0.50535 0.35153 0.40989 0.16172  0.01148  -0.06081 580 HOH A O   
2998 O O   . HOH E .   ? 0.77219 0.99556 0.68409 0.01040  0.19579  -0.03243 581 HOH A O   
2999 O O   . HOH E .   ? 0.69531 0.26257 0.40499 -0.03090 0.10722  0.07858  582 HOH A O   
3000 O O   . HOH E .   ? 0.49915 0.38896 0.68494 -0.21415 -0.18064 0.08900  583 HOH A O   
3001 O O   . HOH E .   ? 0.20067 0.27765 0.24128 0.00681  0.04488  -0.00868 584 HOH A O   
3002 O O   . HOH E .   ? 0.37800 0.29756 0.21500 -0.05187 -0.05087 0.07187  585 HOH A O   
3003 O O   . HOH E .   ? 0.42295 0.51400 0.25197 0.05300  -0.03628 -0.05991 586 HOH A O   
3004 O O   . HOH E .   ? 0.41076 0.75434 0.37801 0.04461  -0.10314 0.08422  587 HOH A O   
3005 O O   . HOH E .   ? 0.31380 0.30388 0.51808 0.00917  0.06401  -0.05773 588 HOH A O   
3006 O O   . HOH E .   ? 0.31409 0.52289 0.24491 -0.01702 0.06973  -0.03631 589 HOH A O   
3007 O O   . HOH E .   ? 0.34425 0.46078 0.36476 0.05842  0.06352  -0.02392 590 HOH A O   
3008 O O   . HOH E .   ? 0.45723 0.60066 0.77157 -0.06667 0.21506  -0.34521 591 HOH A O   
3009 O O   . HOH E .   ? 0.54201 0.41719 0.33469 -0.07267 -0.00469 -0.02234 592 HOH A O   
3010 O O   . HOH E .   ? 0.49852 0.51759 0.92166 0.11261  0.15850  0.21731  593 HOH A O   
3011 O O   . HOH E .   ? 0.46341 0.43391 0.36575 -0.13094 -0.04700 0.04174  594 HOH A O   
3012 O O   . HOH E .   ? 0.37383 0.88863 0.37709 0.07064  0.08939  -0.13143 595 HOH A O   
3013 O O   . HOH E .   ? 0.26252 0.44374 0.37277 0.01861  0.13739  0.00422  596 HOH A O   
3014 O O   . HOH E .   ? 0.34824 0.96389 0.48753 0.08372  -0.01991 0.07718  597 HOH A O   
3015 O O   . HOH E .   ? 0.29088 0.33504 0.23743 -0.04620 -0.01187 0.05551  598 HOH A O   
3016 O O   . HOH E .   ? 0.51257 0.57197 0.71410 -0.06120 0.19108  0.21892  599 HOH A O   
3017 O O   . HOH E .   ? 0.45811 0.36714 0.28552 -0.00628 -0.08477 0.11041  600 HOH A O   
3018 O O   . HOH E .   ? 0.52524 0.69850 0.46338 -0.05717 0.08230  -0.23476 601 HOH A O   
3019 O O   . HOH E .   ? 0.61384 0.59926 0.39826 -0.14035 -0.10378 0.00882  602 HOH A O   
3020 O O   . HOH E .   ? 0.30356 0.27111 0.39902 -0.02520 0.02231  0.01380  603 HOH A O   
3021 O O   . HOH E .   ? 0.23053 0.46360 0.31255 -0.01818 -0.05642 0.06112  604 HOH A O   
3022 O O   . HOH E .   ? 0.23986 0.27381 0.30086 0.01366  -0.02512 0.01441  605 HOH A O   
3023 O O   . HOH E .   ? 0.52766 0.59553 0.49282 -0.20049 0.02206  -0.11163 606 HOH A O   
3024 O O   . HOH E .   ? 0.28283 0.72864 0.46302 -0.14737 0.02770  -0.01640 607 HOH A O   
3025 O O   . HOH E .   ? 0.36695 1.09917 0.40963 0.13957  -0.06267 0.10611  608 HOH A O   
3026 O O   . HOH E .   ? 0.44850 0.30610 0.37376 -0.00620 0.01543  -0.00175 609 HOH A O   
3027 O O   . HOH E .   ? 0.39433 0.35297 0.28567 -0.08877 0.11019  -0.00856 610 HOH A O   
3028 O O   . HOH E .   ? 0.29260 0.44318 0.26317 0.05819  0.09401  0.15952  611 HOH A O   
3029 O O   . HOH E .   ? 0.26332 0.22781 0.20287 -0.06188 -0.03462 0.01534  612 HOH A O   
3030 O O   . HOH E .   ? 0.18638 0.19375 0.28252 -0.02404 0.01441  0.00225  613 HOH A O   
3031 O O   . HOH E .   ? 0.44877 0.55871 0.37371 0.08495  0.06307  0.19691  614 HOH A O   
3032 O O   . HOH E .   ? 0.20956 0.23356 0.17825 0.01184  0.01660  0.03301  615 HOH A O   
3033 O O   . HOH E .   ? 0.41658 0.25909 0.45263 0.00064  0.03383  0.03511  616 HOH A O   
3034 O O   . HOH E .   ? 0.22861 0.48950 0.27371 0.11667  0.02090  0.07560  617 HOH A O   
3035 O O   . HOH E .   ? 0.70854 0.48207 0.58700 -0.23857 -0.20390 0.25096  618 HOH A O   
3036 O O   . HOH E .   ? 0.56240 0.52023 1.14387 -0.07771 -0.13770 -0.04757 619 HOH A O   
3037 O O   . HOH E .   ? 0.98440 0.78644 0.45609 -0.26029 -0.23142 0.22945  620 HOH A O   
3038 O O   . HOH E .   ? 0.66054 0.65640 0.56848 -0.18237 -0.08724 0.24334  621 HOH A O   
3039 O O   . HOH E .   ? 0.54157 0.87800 0.71287 -0.10280 -0.20087 0.00419  622 HOH A O   
3040 O O   . HOH E .   ? 0.45714 0.24823 0.25305 0.02261  -0.07278 0.05350  623 HOH A O   
3041 O O   . HOH E .   ? 0.21054 0.18265 0.27380 0.01752  -0.01740 0.00678  624 HOH A O   
3042 O O   . HOH E .   ? 0.51484 0.47138 0.74877 -0.19005 -0.07346 0.16316  625 HOH A O   
3043 O O   . HOH E .   ? 0.51413 0.54449 0.81675 0.12206  -0.16876 -0.13001 626 HOH A O   
3044 O O   . HOH E .   ? 0.99858 0.45201 0.40285 -0.11660 -0.11939 -0.05941 627 HOH A O   
3045 O O   . HOH E .   ? 0.46298 0.44514 0.23776 -0.06956 -0.10346 0.00315  628 HOH A O   
3046 O O   . HOH E .   ? 0.62998 0.41786 0.42172 -0.12865 -0.09753 0.00964  629 HOH A O   
3047 O O   . HOH E .   ? 0.33633 1.06666 0.80147 -0.10855 -0.12861 -0.12032 630 HOH A O   
3048 O O   . HOH E .   ? 0.27785 0.30362 0.19255 -0.01278 0.01737  0.03663  631 HOH A O   
3049 O O   . HOH E .   ? 0.59916 0.64203 0.74456 0.11847  -0.15487 0.10169  632 HOH A O   
3050 O O   . HOH E .   ? 0.89025 0.55440 0.86801 0.30492  0.13731  0.27501  633 HOH A O   
3051 O O   . HOH E .   ? 0.58457 0.79796 0.61453 0.06139  -0.21512 -0.02894 634 HOH A O   
3052 O O   . HOH E .   ? 0.36280 0.33080 0.40900 -0.02202 -0.03598 -0.01129 635 HOH A O   
3053 O O   . HOH E .   ? 0.79499 0.43895 0.56100 -0.09035 -0.06825 0.26351  636 HOH A O   
3054 O O   . HOH E .   ? 0.66436 0.54033 0.63023 0.27618  0.23751  -0.00888 637 HOH A O   
3055 O O   A HOH E .   ? 0.29579 0.50222 0.34796 -0.05990 -0.01167 -0.05640 638 HOH A O   
3056 O O   . HOH E .   ? 0.51823 0.89446 1.04343 0.16941  0.33936  -0.03372 639 HOH A O   
3057 O O   . HOH E .   ? 0.87955 0.51006 0.67451 -0.33590 -0.17503 -0.01945 640 HOH A O   
3058 O O   . HOH E .   ? 0.37822 0.25982 0.28601 -0.08367 -0.05415 0.06442  641 HOH A O   
3059 O O   . HOH E .   ? 0.32445 0.26767 0.31829 -0.02094 -0.05830 0.07828  642 HOH A O   
3060 O O   . HOH E .   ? 0.42872 0.59798 0.42974 -0.07023 0.15241  0.05799  643 HOH A O   
3061 O O   . HOH E .   ? 0.50360 0.90347 0.47239 0.21737  0.06920  0.01960  644 HOH A O   
3062 O O   . HOH E .   ? 0.69511 0.33624 1.05042 -0.04309 -0.28981 0.14056  645 HOH A O   
3063 O O   . HOH E .   ? 0.91398 0.64082 0.59985 0.14313  0.03828  -0.16309 646 HOH A O   
3064 O O   . HOH E .   ? 0.42045 0.39925 0.15977 0.06364  -0.00782 -0.00770 647 HOH A O   
3065 O O   . HOH E .   ? 0.15889 0.26165 0.29061 -0.02541 -0.02367 0.00061  648 HOH A O   
3066 O O   . HOH E .   ? 0.42307 0.94578 0.39093 0.08567  -0.03307 0.11528  649 HOH A O   
3067 O O   . HOH E .   ? 0.27703 0.25989 0.26077 0.04040  -0.01199 -0.00061 650 HOH A O   
3068 O O   . HOH E .   ? 0.31570 0.37381 0.53869 0.12155  0.00164  -0.07002 651 HOH A O   
3069 O O   . HOH E .   ? 0.44004 0.77866 0.43368 -0.21102 -0.13607 -0.06214 652 HOH A O   
3070 O O   . HOH E .   ? 0.51010 0.61151 0.42449 0.06643  0.02891  0.01723  653 HOH A O   
3071 O O   . HOH E .   ? 0.37669 0.40619 0.42721 0.14486  0.14964  0.21962  654 HOH A O   
3072 O O   . HOH E .   ? 0.20785 0.26214 0.29150 0.01833  0.04445  0.05609  655 HOH A O   
3073 O O   . HOH E .   ? 0.44033 0.26577 0.35060 -0.04207 0.12381  -0.02479 656 HOH A O   
3074 O O   . HOH E .   ? 0.59015 0.61952 0.75532 -0.26113 -0.20094 0.13511  657 HOH A O   
3075 O O   . HOH E .   ? 0.41969 0.41406 0.57471 0.17526  -0.09090 -0.00795 658 HOH A O   
3076 O O   . HOH E .   ? 0.62586 0.76285 0.34957 0.10720  -0.04087 0.18724  659 HOH A O   
3077 O O   . HOH E .   ? 0.30350 0.35456 0.32113 -0.13109 -0.01206 0.07722  660 HOH A O   
3078 O O   . HOH E .   ? 0.40741 0.65507 0.39900 0.04093  0.04693  0.02892  661 HOH A O   
3079 O O   . HOH E .   ? 0.48401 0.77721 0.50570 0.26971  0.02989  0.03324  662 HOH A O   
3080 O O   . HOH E .   ? 0.35766 0.18486 0.25807 -0.00530 0.02432  0.02005  663 HOH A O   
3081 O O   . HOH E .   ? 0.17916 0.25925 0.15703 0.01236  -0.02109 0.01969  664 HOH A O   
3082 O O   . HOH E .   ? 0.58137 0.90084 0.53579 0.31527  -0.15048 -0.05270 665 HOH A O   
3083 O O   . HOH E .   ? 0.56648 0.49275 0.38417 0.12412  0.23634  -0.03279 666 HOH A O   
3084 O O   . HOH E .   ? 0.24994 0.43028 0.37766 0.02296  -0.06500 -0.02681 667 HOH A O   
3085 O O   . HOH E .   ? 0.43308 0.66093 0.36863 -0.05973 0.14453  -0.07331 668 HOH A O   
3086 O O   . HOH E .   ? 0.62271 0.49753 0.79197 -0.07266 -0.12337 0.04899  669 HOH A O   
3087 O O   . HOH E .   ? 0.68213 0.73133 0.47250 -0.22396 0.06575  0.17566  670 HOH A O   
3088 O O   . HOH E .   ? 0.21709 0.23125 0.28893 -0.02930 0.02832  0.00206  671 HOH A O   
3089 O O   . HOH E .   ? 0.59190 0.38264 1.00598 -0.09277 -0.28843 0.23027  672 HOH A O   
3090 O O   . HOH E .   ? 0.87001 0.41804 0.81744 -0.29331 -0.04897 0.10482  673 HOH A O   
3091 O O   . HOH E .   ? 0.30460 0.40610 0.23952 0.00140  -0.04050 0.01820  674 HOH A O   
3092 O O   . HOH E .   ? 0.56158 0.79420 0.68611 0.15149  -0.18328 0.14166  675 HOH A O   
3093 O O   . HOH E .   ? 0.22427 0.24742 0.20644 0.03946  0.02433  0.03313  676 HOH A O   
3094 O O   . HOH E .   ? 0.66994 0.57051 0.75380 -0.28191 -0.09480 -0.04535 677 HOH A O   
3095 O O   . HOH E .   ? 0.58637 0.43307 0.38948 0.07276  0.16146  -0.05279 678 HOH A O   
3096 O O   . HOH E .   ? 0.75511 0.54465 0.87066 0.00853  0.08481  0.33733  679 HOH A O   
3097 O O   . HOH E .   ? 0.33559 0.28377 0.45267 -0.07969 -0.10528 0.06546  680 HOH A O   
3098 O O   . HOH E .   ? 0.58512 0.68071 0.55335 -0.14881 0.18087  -0.16074 681 HOH A O   
3099 O O   . HOH E .   ? 0.41891 0.60732 0.64195 -0.09015 -0.20625 0.11979  682 HOH A O   
3100 O O   . HOH E .   ? 0.38375 0.32673 0.54842 0.04646  0.01722  0.04044  683 HOH A O   
3101 O O   . HOH E .   ? 0.26435 0.36483 0.33406 -0.00515 0.03344  -0.01938 684 HOH A O   
3102 O O   . HOH E .   ? 0.57106 0.42103 0.29878 0.03422  0.07539  -0.07016 685 HOH A O   
3103 O O   . HOH E .   ? 0.61754 0.69156 0.70367 0.34719  0.00738  0.08225  686 HOH A O   
3104 O O   . HOH E .   ? 0.27518 0.39604 0.50810 0.12139  0.01882  -0.13090 687 HOH A O   
3105 O O   . HOH E .   ? 0.59082 0.59874 0.30620 0.05406  -0.07060 -0.06885 688 HOH A O   
3106 O O   . HOH E .   ? 0.31262 0.45150 0.27254 0.02950  0.00400  -0.06875 689 HOH A O   
3107 O O   . HOH E .   ? 0.76281 0.32992 0.89067 0.05938  -0.13926 -0.16742 690 HOH A O   
3108 O O   . HOH E .   ? 0.47842 0.43641 0.36979 -0.18047 -0.14079 0.13414  691 HOH A O   
3109 O O   . HOH E .   ? 0.22384 0.37309 0.31571 -0.03212 0.03698  0.04701  692 HOH A O   
3110 O O   . HOH E .   ? 0.63627 0.54356 0.59887 0.14091  -0.08863 -0.13942 693 HOH A O   
3111 O O   . HOH E .   ? 0.49882 0.22852 0.46580 0.00700  0.17919  0.01512  694 HOH A O   
3112 O O   . HOH E .   ? 0.34581 0.44009 0.82076 0.10396  0.01255  -0.11581 695 HOH A O   
3113 O O   . HOH E .   ? 0.69247 0.61068 0.69444 0.13253  -0.23973 -0.11297 696 HOH A O   
3114 O O   . HOH E .   ? 0.23410 0.32734 0.35356 -0.00817 -0.03887 0.04184  697 HOH A O   
3115 O O   . HOH E .   ? 0.76289 0.40426 0.26384 0.02150  -0.02069 0.00386  698 HOH A O   
3116 O O   . HOH E .   ? 0.28333 0.33810 0.32994 0.14121  -0.01113 -0.06253 699 HOH A O   
3117 O O   . HOH E .   ? 0.34711 0.65352 0.45689 0.08355  0.00438  0.17918  700 HOH A O   
3118 O O   . HOH E .   ? 0.75119 0.93496 0.40818 -0.34051 0.08925  0.11824  701 HOH A O   
3119 O O   . HOH E .   ? 0.48184 0.82162 0.37637 0.09665  0.04460  0.11401  702 HOH A O   
3120 O O   . HOH E .   ? 0.81496 0.42310 0.38390 0.00287  -0.11533 -0.04228 703 HOH A O   
3121 O O   . HOH E .   ? 0.44707 0.44467 0.39858 0.00122  0.09778  -0.06289 704 HOH A O   
3122 O O   . HOH E .   ? 0.62257 0.40916 0.35985 0.11264  0.15522  0.12746  705 HOH A O   
3123 O O   . HOH E .   ? 0.54302 0.40336 0.58830 -0.06836 0.01666  -0.08869 706 HOH A O   
3124 O O   . HOH E .   ? 0.27656 0.15934 0.32765 -0.00291 -0.04591 0.05853  707 HOH A O   
3125 O O   . HOH E .   ? 0.36292 0.30253 0.31608 0.00511  0.02949  -0.05789 708 HOH A O   
3126 O O   . HOH E .   ? 0.30001 0.94196 0.85040 -0.07354 0.04524  -0.25512 709 HOH A O   
3127 O O   . HOH E .   ? 0.18362 0.46779 0.48234 -0.06003 0.04405  -0.01621 710 HOH A O   
3128 O O   . HOH E .   ? 0.39655 0.49267 0.23018 0.03068  -0.00102 0.04217  711 HOH A O   
3129 O O   . HOH E .   ? 0.37557 0.45473 0.30655 -0.05428 -0.01903 0.08283  712 HOH A O   
3130 O O   . HOH E .   ? 0.25710 0.39265 0.34022 -0.08450 -0.10234 0.09995  713 HOH A O   
3131 O O   . HOH E .   ? 0.62370 1.03563 0.47411 0.26122  -0.22599 -0.14051 714 HOH A O   
3132 O O   A HOH E .   ? 0.32169 0.27513 0.26959 -0.12705 -0.06503 0.11487  715 HOH A O   
3133 O O   B HOH E .   ? 0.73642 0.69030 0.66895 0.12850  -0.01588 -0.01120 715 HOH A O   
3134 O O   . HOH E .   ? 1.21275 0.52802 0.61249 0.05664  -0.29616 0.16560  716 HOH A O   
3135 O O   . HOH E .   ? 0.30912 0.30003 0.62589 -0.07569 -0.01318 0.19131  717 HOH A O   
3136 O O   . HOH E .   ? 0.46112 0.47824 0.24719 0.07747  -0.04623 0.06365  718 HOH A O   
3137 O O   . HOH E .   ? 0.37291 0.51995 0.40887 0.03482  0.14941  0.00506  719 HOH A O   
3138 O O   . HOH E .   ? 0.41552 0.61670 0.43059 -0.10882 -0.00190 -0.07638 720 HOH A O   
3139 O O   . HOH E .   ? 0.39129 0.36071 0.59514 -0.04837 -0.04143 -0.00537 721 HOH A O   
3140 O O   . HOH E .   ? 0.42055 0.79014 0.56564 -0.16094 -0.20043 0.30188  722 HOH A O   
3141 O O   . HOH E .   ? 0.75395 0.85894 0.40458 0.20337  -0.17544 0.01806  723 HOH A O   
3142 O O   . HOH E .   ? 0.40423 0.64974 0.31279 -0.21104 -0.00453 0.11942  724 HOH A O   
3143 O O   . HOH E .   ? 0.59253 0.41928 0.41064 -0.01308 0.03384  0.02019  725 HOH A O   
3144 O O   . HOH E .   ? 0.35550 0.77387 0.81395 -0.06771 -0.10582 0.27336  726 HOH A O   
3145 O O   . HOH E .   ? 0.58923 0.35733 0.76655 -0.06606 -0.28519 0.20520  727 HOH A O   
3146 O O   . HOH E .   ? 0.38276 1.17617 0.48476 -0.02014 -0.07978 0.26775  728 HOH A O   
3147 O O   . HOH E .   ? 0.30083 0.33634 0.45053 0.04694  0.00748  -0.05373 729 HOH A O   
3148 O O   . HOH E .   ? 0.30123 0.25084 0.26770 0.07581  0.04690  0.06389  730 HOH A O   
3149 O O   . HOH E .   ? 0.59281 0.56853 0.75020 0.18956  -0.13547 -0.12448 731 HOH A O   
3150 O O   . HOH E .   ? 0.78724 0.83634 0.66495 0.25504  -0.07056 0.34086  732 HOH A O   
3151 O O   . HOH E .   ? 0.62041 0.53415 0.39168 -0.03622 0.27931  0.00070  733 HOH A O   
3152 O O   . HOH E .   ? 0.54219 0.88647 0.35279 0.08717  -0.06601 0.22187  734 HOH A O   
3153 O O   . HOH E .   ? 0.37479 0.49898 0.50489 -0.00783 0.22345  0.02264  735 HOH A O   
3154 O O   . HOH E .   ? 0.57577 0.56577 0.64756 0.09193  -0.16014 -0.26984 736 HOH A O   
3155 O O   . HOH E .   ? 0.27669 0.25131 0.85832 -0.03012 0.16908  -0.11172 737 HOH A O   
3156 O O   . HOH E .   ? 0.70697 0.94686 0.59037 -0.19650 -0.17592 0.16113  738 HOH A O   
3157 O O   . HOH E .   ? 0.68101 0.62597 0.59111 0.17390  0.27646  0.03866  739 HOH A O   
3158 O O   . HOH E .   ? 0.39579 0.42609 0.39876 -0.18857 0.11921  -0.05323 740 HOH A O   
3159 O O   . HOH E .   ? 0.79280 0.51060 0.53553 -0.10566 0.13724  0.15581  741 HOH A O   
3160 O O   . HOH E .   ? 0.27039 0.58087 0.50127 0.10921  0.00346  0.10213  742 HOH A O   
3161 O O   . HOH E .   ? 0.52788 0.85437 0.53501 -0.05355 0.05640  0.26127  743 HOH A O   
3162 O O   . HOH E .   ? 0.73890 0.46757 0.70262 0.14213  0.00842  -0.16450 744 HOH A O   
3163 O O   . HOH E .   ? 0.71114 0.73791 0.74286 -0.37296 -0.08537 0.26688  745 HOH A O   
3164 O O   . HOH E .   ? 0.60719 0.48271 0.91045 -0.13363 -0.28971 -0.13090 746 HOH A O   
3165 O O   . HOH E .   ? 0.90977 0.68638 0.53544 0.04531  0.32890  0.19688  747 HOH A O   
3166 O O   . HOH E .   ? 0.25803 0.35632 0.54967 -0.00188 -0.08291 0.07294  748 HOH A O   
3167 O O   . HOH E .   ? 1.12007 0.37382 0.44494 0.19003  -0.22188 -0.00997 749 HOH A O   
3168 O O   . HOH E .   ? 0.72237 0.58075 0.45076 0.27895  0.05185  0.14006  750 HOH A O   
3169 O O   . HOH E .   ? 0.67428 0.52174 0.34453 -0.15920 -0.23649 0.07344  751 HOH A O   
3170 O O   . HOH E .   ? 0.49494 0.35674 0.42937 0.08674  -0.09779 -0.07729 752 HOH A O   
3171 O O   . HOH E .   ? 0.57280 0.71232 0.46130 -0.18336 -0.15306 0.12982  753 HOH A O   
3172 O O   . HOH E .   ? 0.77065 0.61585 1.06104 0.32797  0.21719  0.02317  754 HOH A O   
3173 O O   . HOH E .   ? 0.84697 0.57531 0.90718 -0.03690 -0.16372 0.09512  755 HOH A O   
3174 O O   . HOH E .   ? 0.75940 0.69451 0.34311 0.38859  0.12260  0.13448  756 HOH A O   
3175 O O   . HOH E .   ? 0.71636 0.45568 0.44506 -0.08562 0.09757  0.01866  757 HOH A O   
3176 O O   . HOH E .   ? 1.04031 0.86440 0.43384 -0.07051 0.13983  0.27492  758 HOH A O   
3177 O O   . HOH E .   ? 0.46068 0.79558 1.00373 0.03946  0.27965  0.05066  759 HOH A O   
3178 O O   . HOH E .   ? 0.73944 0.40689 0.31234 0.06049  0.03307  0.01697  760 HOH A O   
3179 O O   . HOH E .   ? 0.30452 0.43132 0.41278 -0.06857 -0.01626 0.14478  761 HOH A O   
3180 O O   . HOH E .   ? 0.54985 1.10456 0.38008 -0.22076 -0.11005 0.20579  762 HOH A O   
3181 O O   . HOH E .   ? 0.53813 0.61794 0.69608 0.23698  -0.30292 -0.20189 763 HOH A O   
3182 O O   . HOH E .   ? 0.23882 0.44240 0.57858 -0.08076 0.02340  -0.18312 764 HOH A O   
3183 O O   . HOH E .   ? 0.67558 0.39767 0.29085 -0.01289 0.01529  0.07618  765 HOH A O   
3184 O O   . HOH E .   ? 0.36958 0.50939 0.64769 -0.03423 -0.10541 -0.05426 766 HOH A O   
3185 O O   . HOH E .   ? 0.44579 0.49863 0.70201 0.13533  0.08051  0.06421  767 HOH A O   
3186 O O   . HOH E .   ? 0.39887 0.84974 0.38879 0.17733  -0.01987 -0.14695 768 HOH A O   
3187 O O   . HOH E .   ? 0.51289 0.46100 0.39567 0.07549  -0.20321 0.03900  769 HOH A O   
3188 O O   . HOH E .   ? 0.36453 0.75792 0.46234 0.16584  -0.02462 -0.22726 770 HOH A O   
3189 O O   . HOH E .   ? 0.53657 0.83771 0.99061 0.19144  0.04046  -0.31581 771 HOH A O   
3190 O O   . HOH E .   ? 0.66364 0.77953 0.66344 0.09142  -0.08324 0.20869  772 HOH A O   
3191 O O   . HOH E .   ? 0.83614 0.63892 0.52155 -0.15799 0.22147  -0.09187 773 HOH A O   
3192 O O   . HOH E .   ? 1.12842 0.41758 0.37596 -0.22535 -0.02815 -0.02190 774 HOH A O   
3193 O O   . HOH E .   ? 0.23027 0.32317 0.21312 -0.01441 0.02315  0.01690  775 HOH A O   
3194 O O   . HOH E .   ? 0.47706 0.87504 0.91462 0.09741  -0.18499 0.13744  776 HOH A O   
3195 O O   . HOH E .   ? 0.71328 0.63192 0.76866 -0.26665 -0.16018 0.08230  777 HOH A O   
3196 O O   . HOH E .   ? 0.76365 0.81209 0.59665 -0.24763 0.07797  -0.24786 778 HOH A O   
3197 O O   . HOH E .   ? 0.27657 0.33582 0.27108 0.11144  0.00987  0.01011  779 HOH A O   
3198 O O   . HOH E .   ? 0.44834 0.39943 0.89119 0.04990  0.12315  -0.18995 780 HOH A O   
3199 O O   . HOH E .   ? 0.38435 0.61118 0.39089 -0.07646 0.15348  -0.07078 781 HOH A O   
3200 O O   . HOH E .   ? 0.32787 0.45949 0.33074 0.02134  -0.02711 -0.03147 782 HOH A O   
3201 O O   . HOH E .   ? 0.38488 0.39526 0.81730 0.04558  -0.18539 -0.03635 783 HOH A O   
3202 O O   . HOH E .   ? 0.36076 0.53631 0.84396 0.02544  -0.08383 -0.06854 784 HOH A O   
3203 O O   . HOH E .   ? 0.68787 0.71007 0.61824 -0.13787 -0.27177 0.02057  785 HOH A O   
3204 O O   . HOH E .   ? 0.85717 0.73746 0.70802 0.06565  -0.01667 -0.00987 786 HOH A O   
3205 O O   . HOH E .   ? 1.04029 0.75651 0.70485 -0.22288 0.17569  0.24286  787 HOH A O   
3206 O O   . HOH E .   ? 0.74976 0.32493 1.09673 0.13536  0.06784  0.08113  788 HOH A O   
3207 O O   . HOH E .   ? 0.43618 0.43466 0.90486 -0.05580 0.02018  0.03221  789 HOH A O   
3208 O O   . HOH E .   ? 0.51130 0.75359 0.65845 0.07386  -0.10264 -0.18544 790 HOH A O   
3209 O O   . HOH E .   ? 0.46918 0.38012 0.43445 0.03144  0.08837  0.05213  791 HOH A O   
3210 O O   . HOH E .   ? 0.44371 0.84105 0.61372 0.11529  -0.02001 -0.02574 792 HOH A O   
3211 O O   . HOH E .   ? 0.55728 0.99435 0.75515 0.17913  0.11731  0.49841  793 HOH A O   
3212 O O   . HOH E .   ? 0.87882 0.57919 0.75402 0.04528  0.09023  -0.32866 794 HOH A O   
3213 O O   . HOH E .   ? 0.86373 0.57935 0.70117 -0.02351 0.26606  -0.12894 795 HOH A O   
3214 O O   . HOH E .   ? 0.45619 0.84978 0.78382 -0.26282 -0.21516 0.24456  796 HOH A O   
3215 O O   . HOH E .   ? 0.50641 0.25442 0.29002 0.02317  0.04970  0.08030  797 HOH A O   
3216 O O   . HOH E .   ? 0.54503 0.99453 0.45044 0.00515  -0.07289 0.13001  798 HOH A O   
3217 O O   . HOH E .   ? 0.39346 0.55581 0.45608 0.10079  -0.05548 -0.07073 799 HOH A O   
3218 O O   . HOH E .   ? 0.55285 0.58610 0.92962 0.25388  -0.13720 -0.28130 800 HOH A O   
3219 O O   . HOH E .   ? 1.06316 0.78188 0.39600 0.07193  -0.14909 0.07664  801 HOH A O   
3220 O O   . HOH E .   ? 1.00785 0.88520 0.38798 0.18038  0.04256  -0.16260 802 HOH A O   
3221 O O   . HOH E .   ? 0.52974 0.61045 1.02218 -0.09856 -0.22326 0.12365  803 HOH A O   
3222 O O   . HOH E .   ? 0.74277 0.70974 0.56870 -0.03495 -0.08112 0.25999  804 HOH A O   
3223 O O   . HOH E .   ? 0.60163 0.89120 0.42028 -0.21630 -0.01107 -0.16622 805 HOH A O   
3224 O O   . HOH E .   ? 0.34891 0.47237 0.83443 -0.01618 0.03251  0.33796  806 HOH A O   
3225 O O   . HOH E .   ? 0.44486 0.77582 0.94934 -0.23590 -0.17761 0.31541  807 HOH A O   
3226 O O   . HOH E .   ? 0.45604 0.90117 0.67198 -0.20832 -0.06052 0.29798  808 HOH A O   
3227 O O   . HOH E .   ? 0.41951 0.55781 0.52215 -0.00917 0.15837  -0.11028 809 HOH A O   
3228 O O   . HOH E .   ? 0.76095 0.37413 1.09261 -0.02034 -0.03380 0.25240  810 HOH A O   
3229 O O   . HOH E .   ? 0.83985 0.42997 0.46340 0.01767  0.20931  0.17447  811 HOH A O   
3230 O O   . HOH E .   ? 0.78274 0.62220 0.45459 -0.37680 -0.20046 0.08973  812 HOH A O   
3231 O O   . HOH E .   ? 0.53008 0.76005 0.37320 -0.29771 -0.16756 0.13607  813 HOH A O   
3232 O O   . HOH E .   ? 0.47855 0.51474 0.25620 0.02900  0.03097  0.02469  814 HOH A O   
3233 O O   . HOH E .   ? 0.32946 0.42851 0.32254 -0.06635 -0.04685 0.06819  815 HOH A O   
3234 O O   . HOH E .   ? 0.69820 0.77489 0.44766 -0.08443 0.17065  0.07853  816 HOH A O   
3235 O O   . HOH E .   ? 0.78082 0.72116 0.69746 -0.23765 0.09871  0.29424  817 HOH A O   
3236 O O   . HOH E .   ? 0.54464 0.91106 0.43546 0.13693  -0.04570 0.08843  818 HOH A O   
3237 O O   . HOH E .   ? 0.77607 0.86134 0.45462 -0.44905 -0.01572 0.04139  819 HOH A O   
3238 O O   . HOH E .   ? 0.59500 0.87918 0.69141 -0.35006 -0.19757 0.34687  820 HOH A O   
3239 O O   . HOH E .   ? 0.32451 0.78942 0.65431 -0.04833 0.01243  0.23903  821 HOH A O   
3240 O O   . HOH E .   ? 0.56292 0.72896 0.58465 0.16198  0.19090  0.28196  822 HOH A O   
3241 O O   . HOH E .   ? 0.71438 0.51062 0.51469 -0.27976 0.30493  -0.15760 823 HOH A O   
3242 O O   . HOH E .   ? 0.73505 0.63262 0.46582 -0.19292 0.03272  0.00381  824 HOH A O   
3243 O O   . HOH E .   ? 1.09496 0.72708 0.38004 -0.04748 -0.23997 0.04423  825 HOH A O   
3244 O O   . HOH E .   ? 0.71430 0.96364 0.64794 -0.22124 0.12433  -0.40225 826 HOH A O   
3245 O O   . HOH E .   ? 0.44480 0.52048 0.50140 -0.00278 -0.02412 -0.14804 827 HOH A O   
3246 O O   . HOH E .   ? 0.73720 0.86454 0.63013 -0.33880 -0.20333 0.17065  828 HOH A O   
3247 O O   . HOH E .   ? 1.16641 0.61162 0.52251 0.29260  -0.02919 -0.19874 829 HOH A O   
3248 O O   . HOH E .   ? 1.06574 0.29435 0.32657 0.03901  0.03870  -0.03584 830 HOH A O   
3249 O O   . HOH E .   ? 0.81734 0.50837 0.57189 -0.17085 -0.15686 0.15442  831 HOH A O   
3250 O O   . HOH E .   ? 0.49606 0.47471 0.37466 0.08355  0.10050  0.10253  832 HOH A O   
3251 O O   . HOH E .   ? 0.68458 0.86323 0.47930 0.36893  0.00306  0.07912  833 HOH A O   
3252 O O   . HOH E .   ? 0.41285 0.38483 0.97044 0.10922  -0.20341 -0.00127 834 HOH A O   
3253 O O   . HOH E .   ? 0.37487 0.31784 0.26747 0.06330  -0.01326 -0.06318 835 HOH A O   
3254 O O   . HOH E .   ? 1.10947 0.76555 0.65620 0.05957  0.17316  -0.31350 836 HOH A O   
3255 O O   . HOH E .   ? 0.52778 0.92098 0.52711 -0.12106 0.03300  0.02817  837 HOH A O   
3256 O O   . HOH E .   ? 0.94803 0.36338 0.46977 0.05730  0.12145  0.01386  838 HOH A O   
3257 O O   . HOH E .   ? 0.64980 0.36177 0.46638 -0.19599 0.01615  0.08293  839 HOH A O   
3258 O O   . HOH E .   ? 0.41015 0.67280 0.66877 0.06833  -0.01083 0.25396  840 HOH A O   
3259 O O   . HOH E .   ? 0.48940 0.55841 0.34883 -0.03076 0.07539  0.09971  841 HOH A O   
3260 O O   . HOH E .   ? 0.55859 0.83794 0.84194 0.06809  0.20749  0.08227  842 HOH A O   
3261 O O   . HOH E .   ? 0.81591 0.59602 1.00478 -0.09697 0.33434  0.10517  843 HOH A O   
3262 O O   . HOH E .   ? 0.60639 0.47258 1.03758 -0.09442 -0.19283 0.22261  844 HOH A O   
3263 O O   . HOH E .   ? 0.64108 0.48197 0.95649 -0.03288 0.05063  -0.07561 845 HOH A O   
3264 O O   . HOH E .   ? 0.60716 0.53285 0.29626 -0.06984 0.09878  0.01794  846 HOH A O   
3265 O O   . HOH E .   ? 0.81865 0.85699 0.60434 -0.07201 0.15560  -0.01835 847 HOH A O   
3266 O O   . HOH E .   ? 0.81514 0.61180 0.73432 -0.22334 0.08223  0.26369  848 HOH A O   
3267 O O   . HOH E .   ? 0.76316 0.53876 0.71431 0.11135  -0.32892 -0.05758 849 HOH A O   
3268 O O   . HOH E .   ? 0.85227 0.61087 0.27766 0.12556  0.03741  0.05717  850 HOH A O   
3269 O O   . HOH E .   ? 0.45917 0.82861 0.64881 0.10417  0.07221  -0.04744 851 HOH A O   
3270 O O   . HOH E .   ? 0.70839 0.68053 0.62941 -0.22916 -0.35568 0.24297  852 HOH A O   
3271 O O   . HOH E .   ? 0.73688 0.81760 0.30845 -0.32105 -0.04684 0.09201  853 HOH A O   
3272 O O   . HOH E .   ? 0.61313 0.37889 0.54509 0.00400  -0.12734 0.12259  854 HOH A O   
3273 O O   . HOH E .   ? 0.59597 0.91784 0.55849 0.31042  0.15032  0.19430  855 HOH A O   
3274 O O   . HOH E .   ? 0.45154 0.57213 0.96516 0.20589  -0.18487 -0.07641 856 HOH A O   
3275 O O   . HOH E .   ? 0.47638 0.90698 0.49490 -0.13057 -0.01245 0.31434  857 HOH A O   
3276 O O   . HOH E .   ? 0.46425 1.01668 0.72050 -0.00030 0.24267  0.14745  858 HOH A O   
3277 O O   . HOH E .   ? 0.78453 0.78899 0.59472 -0.12665 -0.04360 -0.09902 859 HOH A O   
3278 O O   . HOH E .   ? 1.04230 0.52114 0.46474 -0.36064 -0.03345 0.09049  860 HOH A O   
3279 O O   . HOH E .   ? 0.62905 0.52343 1.00319 -0.07810 0.13903  -0.05985 861 HOH A O   
3280 O O   . HOH E .   ? 0.54435 0.98385 0.67686 -0.28040 0.25281  -0.37070 862 HOH A O   
3281 O O   . HOH E .   ? 0.64639 0.48645 0.77483 0.02991  -0.09016 0.09578  863 HOH A O   
3282 O O   . HOH E .   ? 0.79973 0.80316 0.70982 0.08485  0.38126  -0.09594 864 HOH A O   
3283 O O   . HOH E .   ? 1.15234 0.48455 0.50142 0.16820  0.15973  -0.12517 865 HOH A O   
3284 O O   . HOH E .   ? 0.65070 0.68543 0.36986 -0.00218 0.07371  -0.09416 866 HOH A O   
3285 O O   . HOH E .   ? 0.82272 0.42070 0.90223 0.02792  -0.33631 0.08524  867 HOH A O   
3286 O O   . HOH E .   ? 1.12430 0.62461 0.44122 0.05954  0.02542  -0.02540 868 HOH A O   
3287 O O   . HOH E .   ? 0.43963 0.95092 0.75265 -0.06487 0.03964  0.09773  869 HOH A O   
3288 O O   . HOH E .   ? 0.68815 0.46677 0.56527 0.11380  0.12311  0.06296  870 HOH A O   
3289 O O   . HOH E .   ? 0.72920 0.49133 0.52514 -0.19783 0.11319  0.12226  871 HOH A O   
3290 O O   . HOH E .   ? 0.90272 0.42216 0.63351 -0.17595 -0.17532 0.04473  872 HOH A O   
3291 O O   . HOH E .   ? 1.05944 0.66859 0.74695 -0.17924 0.12741  -0.08671 873 HOH A O   
3292 O O   . HOH E .   ? 0.66761 0.77744 0.69000 0.05125  0.24402  -0.32762 874 HOH A O   
3293 O O   . HOH E .   ? 0.85888 0.80622 0.43965 -0.17065 -0.29999 0.09529  875 HOH A O   
3294 O O   . HOH E .   ? 0.78477 0.90173 0.34574 -0.13110 0.09294  0.09983  876 HOH A O   
# 
