data_9QA1
# 
_entry.id   9QA1 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9QA1         pdb_00009qa1 10.2210/pdb9qa1/pdb 
WWPDB D_1292145606 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-05-14 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9QA1 
_pdbx_database_status.recvd_initial_deposition_date   2025-02-27 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              bsskra@bath.ac.uk 
_pdbx_contact_author.name_first         'K. Ravi' 
_pdbx_contact_author.name_last          Acharya 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-3009-4058 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Zukowska, J.'  1 0009-0003-3668-7211 
'Gregory, K.S.' 2 ?                   
'Acharya, K.R.' 3 ?                   
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   CH 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Biomolecules 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2218-273X 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            15 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Molecular Basis of Dipeptide Recognition in Drosophila melanogaster Angiotensin I-Converting Enzyme Homologue, AnCE.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.3390/biom15040591 
_citation.pdbx_database_id_PubMed   40305366 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Zukowska, J.'  1 0009-0003-3668-7211 
primary 'Gregory, K.S.' 2 0000-0001-5371-4283 
primary 'Robinson, A.'  3 ?                   
primary 'Isaac, R.E.'   4 0000-0003-4792-6559 
primary 'Acharya, K.R.' 5 0000-0002-3009-4058 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Angiotensin-converting enzyme' 68980.414 1   3.4.15.1 ? ? ? 
2 polymer     syn 'VAL-TRP dipeptide' 303.356   2   ?        ? ? ? 
3 branched    man 
;beta-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
;
1072.964  1   ?        ? ? ? 
4 non-polymer syn 'ZINC ION' 65.409    1   ?        ? ? ? 
5 non-polymer syn 2-acetamido-2-deoxy-beta-D-glucopyranose 221.208   2   ?        ? ? ? 
6 water       nat water 18.015    243 ?        ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Dipeptidyl carboxypeptidase I,Kininase II' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;VKEEIQAKEYLENLNKELAKRTNVETEAAWAYGSNITDENEKKKNEISAELAKFMKEVASDTTKFQWRSYQSEDLKRQFK
ALTKLGYAALPEDDYAELLDTLSAMESNFAKVKVCDYKDSTKCDLALDPEIEEVISKSRDHEELAYYWREFYDKAGTAVR
SQFERYVELNTKAAKLNNFTSGAEAWLDEYEDDTFEQQLEDIFADIRPLYQQIHGYVRFRLRKHYGDAVVSETGPIPMHL
LGNMWAQQWSEIADIVSPFPEKPLVDVSAEMEKQGYTPLKMFQMGDDFFTSMNLTKLPQDFWDKSIIEKPTDGRDLVCHA
SAWDFYLIDDVRIKQCTRVTQDQLFTVHHELGHIQYFLQYQHQPFVYRTGANPGFHEAVGDVLSLSVSTPKHLEKIGLLK
DYVRDDEARINQLFLTALDKIVFLPFAFTMDKYRWSLFRGEVDKANWNCAFWKLRDEYSGIEPPVVRSEKDFDAPAKYHI
SADVEYLRYLVSFIIQFQFYKSACIKAGQYDPDNVELPLDNCDIYGSAAAGAAFHNMLSMGASKPWPDALEAFNGERIMS
GKAIAEYFEPLRVWLEAENIKNNVHIGWTTSNKCVS
;
;VKEEIQAKEYLENLNKELAKRTNVETEAAWAYGSNITDENEKKKNEISAELAKFMKEVASDTTKFQWRSYQSEDLKRQFK
ALTKLGYAALPEDDYAELLDTLSAMESNFAKVKVCDYKDSTKCDLALDPEIEEVISKSRDHEELAYYWREFYDKAGTAVR
SQFERYVELNTKAAKLNNFTSGAEAWLDEYEDDTFEQQLEDIFADIRPLYQQIHGYVRFRLRKHYGDAVVSETGPIPMHL
LGNMWAQQWSEIADIVSPFPEKPLVDVSAEMEKQGYTPLKMFQMGDDFFTSMNLTKLPQDFWDKSIIEKPTDGRDLVCHA
SAWDFYLIDDVRIKQCTRVTQDQLFTVHHELGHIQYFLQYQHQPFVYRTGANPGFHEAVGDVLSLSVSTPKHLEKIGLLK
DYVRDDEARINQLFLTALDKIVFLPFAFTMDKYRWSLFRGEVDKANWNCAFWKLRDEYSGIEPPVVRSEKDFDAPAKYHI
SADVEYLRYLVSFIIQFQFYKSACIKAGQYDPDNVELPLDNCDIYGSAAAGAAFHNMLSMGASKPWPDALEAFNGERIMS
GKAIAEYFEPLRVWLEAENIKNNVHIGWTTSNKCVS
;
A   ? 
2 'polypeptide(L)' no no VW VW B,D ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
4 'ZINC ION'                               ZN  
5 2-acetamido-2-deoxy-beta-D-glucopyranose NAG 
6 water                                    HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   VAL n 
1 2   LYS n 
1 3   GLU n 
1 4   GLU n 
1 5   ILE n 
1 6   GLN n 
1 7   ALA n 
1 8   LYS n 
1 9   GLU n 
1 10  TYR n 
1 11  LEU n 
1 12  GLU n 
1 13  ASN n 
1 14  LEU n 
1 15  ASN n 
1 16  LYS n 
1 17  GLU n 
1 18  LEU n 
1 19  ALA n 
1 20  LYS n 
1 21  ARG n 
1 22  THR n 
1 23  ASN n 
1 24  VAL n 
1 25  GLU n 
1 26  THR n 
1 27  GLU n 
1 28  ALA n 
1 29  ALA n 
1 30  TRP n 
1 31  ALA n 
1 32  TYR n 
1 33  GLY n 
1 34  SER n 
1 35  ASN n 
1 36  ILE n 
1 37  THR n 
1 38  ASP n 
1 39  GLU n 
1 40  ASN n 
1 41  GLU n 
1 42  LYS n 
1 43  LYS n 
1 44  LYS n 
1 45  ASN n 
1 46  GLU n 
1 47  ILE n 
1 48  SER n 
1 49  ALA n 
1 50  GLU n 
1 51  LEU n 
1 52  ALA n 
1 53  LYS n 
1 54  PHE n 
1 55  MET n 
1 56  LYS n 
1 57  GLU n 
1 58  VAL n 
1 59  ALA n 
1 60  SER n 
1 61  ASP n 
1 62  THR n 
1 63  THR n 
1 64  LYS n 
1 65  PHE n 
1 66  GLN n 
1 67  TRP n 
1 68  ARG n 
1 69  SER n 
1 70  TYR n 
1 71  GLN n 
1 72  SER n 
1 73  GLU n 
1 74  ASP n 
1 75  LEU n 
1 76  LYS n 
1 77  ARG n 
1 78  GLN n 
1 79  PHE n 
1 80  LYS n 
1 81  ALA n 
1 82  LEU n 
1 83  THR n 
1 84  LYS n 
1 85  LEU n 
1 86  GLY n 
1 87  TYR n 
1 88  ALA n 
1 89  ALA n 
1 90  LEU n 
1 91  PRO n 
1 92  GLU n 
1 93  ASP n 
1 94  ASP n 
1 95  TYR n 
1 96  ALA n 
1 97  GLU n 
1 98  LEU n 
1 99  LEU n 
1 100 ASP n 
1 101 THR n 
1 102 LEU n 
1 103 SER n 
1 104 ALA n 
1 105 MET n 
1 106 GLU n 
1 107 SER n 
1 108 ASN n 
1 109 PHE n 
1 110 ALA n 
1 111 LYS n 
1 112 VAL n 
1 113 LYS n 
1 114 VAL n 
1 115 CYS n 
1 116 ASP n 
1 117 TYR n 
1 118 LYS n 
1 119 ASP n 
1 120 SER n 
1 121 THR n 
1 122 LYS n 
1 123 CYS n 
1 124 ASP n 
1 125 LEU n 
1 126 ALA n 
1 127 LEU n 
1 128 ASP n 
1 129 PRO n 
1 130 GLU n 
1 131 ILE n 
1 132 GLU n 
1 133 GLU n 
1 134 VAL n 
1 135 ILE n 
1 136 SER n 
1 137 LYS n 
1 138 SER n 
1 139 ARG n 
1 140 ASP n 
1 141 HIS n 
1 142 GLU n 
1 143 GLU n 
1 144 LEU n 
1 145 ALA n 
1 146 TYR n 
1 147 TYR n 
1 148 TRP n 
1 149 ARG n 
1 150 GLU n 
1 151 PHE n 
1 152 TYR n 
1 153 ASP n 
1 154 LYS n 
1 155 ALA n 
1 156 GLY n 
1 157 THR n 
1 158 ALA n 
1 159 VAL n 
1 160 ARG n 
1 161 SER n 
1 162 GLN n 
1 163 PHE n 
1 164 GLU n 
1 165 ARG n 
1 166 TYR n 
1 167 VAL n 
1 168 GLU n 
1 169 LEU n 
1 170 ASN n 
1 171 THR n 
1 172 LYS n 
1 173 ALA n 
1 174 ALA n 
1 175 LYS n 
1 176 LEU n 
1 177 ASN n 
1 178 ASN n 
1 179 PHE n 
1 180 THR n 
1 181 SER n 
1 182 GLY n 
1 183 ALA n 
1 184 GLU n 
1 185 ALA n 
1 186 TRP n 
1 187 LEU n 
1 188 ASP n 
1 189 GLU n 
1 190 TYR n 
1 191 GLU n 
1 192 ASP n 
1 193 ASP n 
1 194 THR n 
1 195 PHE n 
1 196 GLU n 
1 197 GLN n 
1 198 GLN n 
1 199 LEU n 
1 200 GLU n 
1 201 ASP n 
1 202 ILE n 
1 203 PHE n 
1 204 ALA n 
1 205 ASP n 
1 206 ILE n 
1 207 ARG n 
1 208 PRO n 
1 209 LEU n 
1 210 TYR n 
1 211 GLN n 
1 212 GLN n 
1 213 ILE n 
1 214 HIS n 
1 215 GLY n 
1 216 TYR n 
1 217 VAL n 
1 218 ARG n 
1 219 PHE n 
1 220 ARG n 
1 221 LEU n 
1 222 ARG n 
1 223 LYS n 
1 224 HIS n 
1 225 TYR n 
1 226 GLY n 
1 227 ASP n 
1 228 ALA n 
1 229 VAL n 
1 230 VAL n 
1 231 SER n 
1 232 GLU n 
1 233 THR n 
1 234 GLY n 
1 235 PRO n 
1 236 ILE n 
1 237 PRO n 
1 238 MET n 
1 239 HIS n 
1 240 LEU n 
1 241 LEU n 
1 242 GLY n 
1 243 ASN n 
1 244 MET n 
1 245 TRP n 
1 246 ALA n 
1 247 GLN n 
1 248 GLN n 
1 249 TRP n 
1 250 SER n 
1 251 GLU n 
1 252 ILE n 
1 253 ALA n 
1 254 ASP n 
1 255 ILE n 
1 256 VAL n 
1 257 SER n 
1 258 PRO n 
1 259 PHE n 
1 260 PRO n 
1 261 GLU n 
1 262 LYS n 
1 263 PRO n 
1 264 LEU n 
1 265 VAL n 
1 266 ASP n 
1 267 VAL n 
1 268 SER n 
1 269 ALA n 
1 270 GLU n 
1 271 MET n 
1 272 GLU n 
1 273 LYS n 
1 274 GLN n 
1 275 GLY n 
1 276 TYR n 
1 277 THR n 
1 278 PRO n 
1 279 LEU n 
1 280 LYS n 
1 281 MET n 
1 282 PHE n 
1 283 GLN n 
1 284 MET n 
1 285 GLY n 
1 286 ASP n 
1 287 ASP n 
1 288 PHE n 
1 289 PHE n 
1 290 THR n 
1 291 SER n 
1 292 MET n 
1 293 ASN n 
1 294 LEU n 
1 295 THR n 
1 296 LYS n 
1 297 LEU n 
1 298 PRO n 
1 299 GLN n 
1 300 ASP n 
1 301 PHE n 
1 302 TRP n 
1 303 ASP n 
1 304 LYS n 
1 305 SER n 
1 306 ILE n 
1 307 ILE n 
1 308 GLU n 
1 309 LYS n 
1 310 PRO n 
1 311 THR n 
1 312 ASP n 
1 313 GLY n 
1 314 ARG n 
1 315 ASP n 
1 316 LEU n 
1 317 VAL n 
1 318 CYS n 
1 319 HIS n 
1 320 ALA n 
1 321 SER n 
1 322 ALA n 
1 323 TRP n 
1 324 ASP n 
1 325 PHE n 
1 326 TYR n 
1 327 LEU n 
1 328 ILE n 
1 329 ASP n 
1 330 ASP n 
1 331 VAL n 
1 332 ARG n 
1 333 ILE n 
1 334 LYS n 
1 335 GLN n 
1 336 CYS n 
1 337 THR n 
1 338 ARG n 
1 339 VAL n 
1 340 THR n 
1 341 GLN n 
1 342 ASP n 
1 343 GLN n 
1 344 LEU n 
1 345 PHE n 
1 346 THR n 
1 347 VAL n 
1 348 HIS n 
1 349 HIS n 
1 350 GLU n 
1 351 LEU n 
1 352 GLY n 
1 353 HIS n 
1 354 ILE n 
1 355 GLN n 
1 356 TYR n 
1 357 PHE n 
1 358 LEU n 
1 359 GLN n 
1 360 TYR n 
1 361 GLN n 
1 362 HIS n 
1 363 GLN n 
1 364 PRO n 
1 365 PHE n 
1 366 VAL n 
1 367 TYR n 
1 368 ARG n 
1 369 THR n 
1 370 GLY n 
1 371 ALA n 
1 372 ASN n 
1 373 PRO n 
1 374 GLY n 
1 375 PHE n 
1 376 HIS n 
1 377 GLU n 
1 378 ALA n 
1 379 VAL n 
1 380 GLY n 
1 381 ASP n 
1 382 VAL n 
1 383 LEU n 
1 384 SER n 
1 385 LEU n 
1 386 SER n 
1 387 VAL n 
1 388 SER n 
1 389 THR n 
1 390 PRO n 
1 391 LYS n 
1 392 HIS n 
1 393 LEU n 
1 394 GLU n 
1 395 LYS n 
1 396 ILE n 
1 397 GLY n 
1 398 LEU n 
1 399 LEU n 
1 400 LYS n 
1 401 ASP n 
1 402 TYR n 
1 403 VAL n 
1 404 ARG n 
1 405 ASP n 
1 406 ASP n 
1 407 GLU n 
1 408 ALA n 
1 409 ARG n 
1 410 ILE n 
1 411 ASN n 
1 412 GLN n 
1 413 LEU n 
1 414 PHE n 
1 415 LEU n 
1 416 THR n 
1 417 ALA n 
1 418 LEU n 
1 419 ASP n 
1 420 LYS n 
1 421 ILE n 
1 422 VAL n 
1 423 PHE n 
1 424 LEU n 
1 425 PRO n 
1 426 PHE n 
1 427 ALA n 
1 428 PHE n 
1 429 THR n 
1 430 MET n 
1 431 ASP n 
1 432 LYS n 
1 433 TYR n 
1 434 ARG n 
1 435 TRP n 
1 436 SER n 
1 437 LEU n 
1 438 PHE n 
1 439 ARG n 
1 440 GLY n 
1 441 GLU n 
1 442 VAL n 
1 443 ASP n 
1 444 LYS n 
1 445 ALA n 
1 446 ASN n 
1 447 TRP n 
1 448 ASN n 
1 449 CYS n 
1 450 ALA n 
1 451 PHE n 
1 452 TRP n 
1 453 LYS n 
1 454 LEU n 
1 455 ARG n 
1 456 ASP n 
1 457 GLU n 
1 458 TYR n 
1 459 SER n 
1 460 GLY n 
1 461 ILE n 
1 462 GLU n 
1 463 PRO n 
1 464 PRO n 
1 465 VAL n 
1 466 VAL n 
1 467 ARG n 
1 468 SER n 
1 469 GLU n 
1 470 LYS n 
1 471 ASP n 
1 472 PHE n 
1 473 ASP n 
1 474 ALA n 
1 475 PRO n 
1 476 ALA n 
1 477 LYS n 
1 478 TYR n 
1 479 HIS n 
1 480 ILE n 
1 481 SER n 
1 482 ALA n 
1 483 ASP n 
1 484 VAL n 
1 485 GLU n 
1 486 TYR n 
1 487 LEU n 
1 488 ARG n 
1 489 TYR n 
1 490 LEU n 
1 491 VAL n 
1 492 SER n 
1 493 PHE n 
1 494 ILE n 
1 495 ILE n 
1 496 GLN n 
1 497 PHE n 
1 498 GLN n 
1 499 PHE n 
1 500 TYR n 
1 501 LYS n 
1 502 SER n 
1 503 ALA n 
1 504 CYS n 
1 505 ILE n 
1 506 LYS n 
1 507 ALA n 
1 508 GLY n 
1 509 GLN n 
1 510 TYR n 
1 511 ASP n 
1 512 PRO n 
1 513 ASP n 
1 514 ASN n 
1 515 VAL n 
1 516 GLU n 
1 517 LEU n 
1 518 PRO n 
1 519 LEU n 
1 520 ASP n 
1 521 ASN n 
1 522 CYS n 
1 523 ASP n 
1 524 ILE n 
1 525 TYR n 
1 526 GLY n 
1 527 SER n 
1 528 ALA n 
1 529 ALA n 
1 530 ALA n 
1 531 GLY n 
1 532 ALA n 
1 533 ALA n 
1 534 PHE n 
1 535 HIS n 
1 536 ASN n 
1 537 MET n 
1 538 LEU n 
1 539 SER n 
1 540 MET n 
1 541 GLY n 
1 542 ALA n 
1 543 SER n 
1 544 LYS n 
1 545 PRO n 
1 546 TRP n 
1 547 PRO n 
1 548 ASP n 
1 549 ALA n 
1 550 LEU n 
1 551 GLU n 
1 552 ALA n 
1 553 PHE n 
1 554 ASN n 
1 555 GLY n 
1 556 GLU n 
1 557 ARG n 
1 558 ILE n 
1 559 MET n 
1 560 SER n 
1 561 GLY n 
1 562 LYS n 
1 563 ALA n 
1 564 ILE n 
1 565 ALA n 
1 566 GLU n 
1 567 TYR n 
1 568 PHE n 
1 569 GLU n 
1 570 PRO n 
1 571 LEU n 
1 572 ARG n 
1 573 VAL n 
1 574 TRP n 
1 575 LEU n 
1 576 GLU n 
1 577 ALA n 
1 578 GLU n 
1 579 ASN n 
1 580 ILE n 
1 581 LYS n 
1 582 ASN n 
1 583 ASN n 
1 584 VAL n 
1 585 HIS n 
1 586 ILE n 
1 587 GLY n 
1 588 TRP n 
1 589 THR n 
1 590 THR n 
1 591 SER n 
1 592 ASN n 
1 593 LYS n 
1 594 CYS n 
1 595 VAL n 
1 596 SER n 
2 1   VAL n 
2 2   TRP n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   596 
_entity_src_gen.gene_src_common_name               'fruit fly' 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'Ance, Race, CG8827' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Drosophila melanogaster' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     7227 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Komagataella phaffii GS115' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     644223 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
_pdbx_entity_src_syn.entity_id              2 
_pdbx_entity_src_syn.pdbx_src_id            1 
_pdbx_entity_src_syn.pdbx_alt_source_flag   sample 
_pdbx_entity_src_syn.pdbx_beg_seq_num       1 
_pdbx_entity_src_syn.pdbx_end_seq_num       2 
_pdbx_entity_src_syn.organism_scientific    'Bos taurus' 
_pdbx_entity_src_syn.organism_common_name   ? 
_pdbx_entity_src_syn.ncbi_taxonomy_id       9913 
_pdbx_entity_src_syn.details                ? 
# 
_pdbx_entity_branch.entity_id   3 
_pdbx_entity_branch.type        oligosaccharide 
# 
loop_
_pdbx_entity_branch_descriptor.ordinal 
_pdbx_entity_branch_descriptor.entity_id 
_pdbx_entity_branch_descriptor.descriptor 
_pdbx_entity_branch_descriptor.type 
_pdbx_entity_branch_descriptor.program 
_pdbx_entity_branch_descriptor.program_version 
1 3 'DManpb1-6DManpa1-3[DManpa1-6]DManpb1-4DGlcpNAcb1-4DGlcpNAcb1-ROH'                                                          
'Glycam Condensed Sequence' GMML       1.0   
2 3 'WURCS=2.0/3,6,5/[a2122h-1b_1-5_2*NCC/3=O][a1122h-1b_1-5][a1122h-1a_1-5]/1-1-2-3-2-3/a4-b1_b4-c1_c3-d1_c6-f1_d6-e1'         
WURCS                       PDB2Glycan 1.1.0 
3 3 '[][D-1-deoxy-GlcpNAc]{[(4+1)][b-D-GlcpNAc]{[(4+1)][b-D-Manp]{[(3+1)][a-D-Manp]{[(6+1)][b-D-Manp]{}}[(6+1)][a-D-Manp]{}}}}' 
LINUCS                      PDB-CARE   ?     
# 
loop_
_pdbx_entity_branch_link.link_id 
_pdbx_entity_branch_link.entity_id 
_pdbx_entity_branch_link.entity_branch_list_num_1 
_pdbx_entity_branch_link.comp_id_1 
_pdbx_entity_branch_link.atom_id_1 
_pdbx_entity_branch_link.leaving_atom_id_1 
_pdbx_entity_branch_link.entity_branch_list_num_2 
_pdbx_entity_branch_link.comp_id_2 
_pdbx_entity_branch_link.atom_id_2 
_pdbx_entity_branch_link.leaving_atom_id_2 
_pdbx_entity_branch_link.value_order 
_pdbx_entity_branch_link.details 
1 3 2 NAG C1 O1 1 NAG O4 HO4 sing ? 
2 3 3 BMA C1 O1 2 NAG O4 HO4 sing ? 
3 3 4 MAN C1 O1 3 BMA O3 HO3 sing ? 
4 3 5 BMA C1 O1 4 MAN O6 HO6 sing ? 
5 3 6 MAN C1 O1 3 BMA O6 HO6 sing ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking'           y ALANINE                                  ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking'           y ARGININE                                 ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking'           y ASPARAGINE                               ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking'           y 'ASPARTIC ACID'                          ? 'C4 H7 N O4'     133.103 
BMA 'D-saccharide, beta linking'  . beta-D-mannopyranose                     'beta-D-mannose; D-mannose; mannose' 'C6 H12 O6'      
180.156 
CYS 'L-peptide linking'           y CYSTEINE                                 ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking'           y GLUTAMINE                                ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking'           y 'GLUTAMIC ACID'                          ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'             y GLYCINE                                  ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking'           y HISTIDINE                                ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer                   . WATER                                    ? 'H2 O'           18.015  
ILE 'L-peptide linking'           y ISOLEUCINE                               ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking'           y LEUCINE                                  ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking'           y LYSINE                                   ? 'C6 H15 N2 O2 1' 147.195 
MAN 'D-saccharide, alpha linking' . alpha-D-mannopyranose                    'alpha-D-mannose; D-mannose; mannose' 'C6 H12 O6' 
180.156 
MET 'L-peptide linking'           y METHIONINE                               ? 'C5 H11 N O2 S'  149.211 
NAG 'D-saccharide, beta linking'  . 2-acetamido-2-deoxy-beta-D-glucopyranose 
;N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE
;
'C8 H15 N O6'    221.208 
PHE 'L-peptide linking'           y PHENYLALANINE                            ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking'           y PROLINE                                  ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking'           y SERINE                                   ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking'           y THREONINE                                ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking'           y TRYPTOPHAN                               ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking'           y TYROSINE                                 ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking'           y VALINE                                   ? 'C5 H11 N O2'    117.146 
ZN  non-polymer                   . 'ZINC ION'                               ? 'Zn 2'           65.409  
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
BMA 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DManpb                         
BMA 'COMMON NAME'                         GMML     1.0 b-D-mannopyranose              
BMA 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-Manp                       
BMA 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 Man                            
MAN 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DManpa                         
MAN 'COMMON NAME'                         GMML     1.0 a-D-mannopyranose              
MAN 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 a-D-Manp                       
MAN 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 Man                            
NAG 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DGlcpNAcb                      
NAG 'COMMON NAME'                         GMML     1.0 N-acetyl-b-D-glucopyranosamine 
NAG 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-GlcpNAc                    
NAG 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 GlcNAc                         
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   VAL 1   19   19   VAL VAL A . n 
A 1 2   LYS 2   20   20   LYS LYS A . n 
A 1 3   GLU 3   21   21   GLU GLU A . n 
A 1 4   GLU 4   22   22   GLU GLU A . n 
A 1 5   ILE 5   23   23   ILE ILE A . n 
A 1 6   GLN 6   24   24   GLN GLN A . n 
A 1 7   ALA 7   25   25   ALA ALA A . n 
A 1 8   LYS 8   26   26   LYS LYS A . n 
A 1 9   GLU 9   27   27   GLU GLU A . n 
A 1 10  TYR 10  28   28   TYR TYR A . n 
A 1 11  LEU 11  29   29   LEU LEU A . n 
A 1 12  GLU 12  30   30   GLU GLU A . n 
A 1 13  ASN 13  31   31   ASN ASN A . n 
A 1 14  LEU 14  32   32   LEU LEU A . n 
A 1 15  ASN 15  33   33   ASN ASN A . n 
A 1 16  LYS 16  34   34   LYS LYS A . n 
A 1 17  GLU 17  35   35   GLU GLU A . n 
A 1 18  LEU 18  36   36   LEU LEU A . n 
A 1 19  ALA 19  37   37   ALA ALA A . n 
A 1 20  LYS 20  38   38   LYS LYS A . n 
A 1 21  ARG 21  39   39   ARG ARG A . n 
A 1 22  THR 22  40   40   THR THR A . n 
A 1 23  ASN 23  41   41   ASN ASN A . n 
A 1 24  VAL 24  42   42   VAL VAL A . n 
A 1 25  GLU 25  43   43   GLU GLU A . n 
A 1 26  THR 26  44   44   THR THR A . n 
A 1 27  GLU 27  45   45   GLU GLU A . n 
A 1 28  ALA 28  46   46   ALA ALA A . n 
A 1 29  ALA 29  47   47   ALA ALA A . n 
A 1 30  TRP 30  48   48   TRP TRP A . n 
A 1 31  ALA 31  49   49   ALA ALA A . n 
A 1 32  TYR 32  50   50   TYR TYR A . n 
A 1 33  GLY 33  51   51   GLY GLY A . n 
A 1 34  SER 34  52   52   SER SER A . n 
A 1 35  ASN 35  53   53   ASN ASN A . n 
A 1 36  ILE 36  54   54   ILE ILE A . n 
A 1 37  THR 37  55   55   THR THR A . n 
A 1 38  ASP 38  56   56   ASP ASP A . n 
A 1 39  GLU 39  57   57   GLU GLU A . n 
A 1 40  ASN 40  58   58   ASN ASN A . n 
A 1 41  GLU 41  59   59   GLU GLU A . n 
A 1 42  LYS 42  60   60   LYS LYS A . n 
A 1 43  LYS 43  61   61   LYS LYS A . n 
A 1 44  LYS 44  62   62   LYS LYS A . n 
A 1 45  ASN 45  63   63   ASN ASN A . n 
A 1 46  GLU 46  64   64   GLU GLU A . n 
A 1 47  ILE 47  65   65   ILE ILE A . n 
A 1 48  SER 48  66   66   SER SER A . n 
A 1 49  ALA 49  67   67   ALA ALA A . n 
A 1 50  GLU 50  68   68   GLU GLU A . n 
A 1 51  LEU 51  69   69   LEU LEU A . n 
A 1 52  ALA 52  70   70   ALA ALA A . n 
A 1 53  LYS 53  71   71   LYS LYS A . n 
A 1 54  PHE 54  72   72   PHE PHE A . n 
A 1 55  MET 55  73   73   MET MET A . n 
A 1 56  LYS 56  74   74   LYS LYS A . n 
A 1 57  GLU 57  75   75   GLU GLU A . n 
A 1 58  VAL 58  76   76   VAL VAL A . n 
A 1 59  ALA 59  77   77   ALA ALA A . n 
A 1 60  SER 60  78   78   SER SER A . n 
A 1 61  ASP 61  79   79   ASP ASP A . n 
A 1 62  THR 62  80   80   THR THR A . n 
A 1 63  THR 63  81   81   THR THR A . n 
A 1 64  LYS 64  82   82   LYS LYS A . n 
A 1 65  PHE 65  83   83   PHE PHE A . n 
A 1 66  GLN 66  84   84   GLN GLN A . n 
A 1 67  TRP 67  85   85   TRP TRP A . n 
A 1 68  ARG 68  86   86   ARG ARG A . n 
A 1 69  SER 69  87   87   SER SER A . n 
A 1 70  TYR 70  88   88   TYR TYR A . n 
A 1 71  GLN 71  89   89   GLN GLN A . n 
A 1 72  SER 72  90   90   SER SER A . n 
A 1 73  GLU 73  91   91   GLU GLU A . n 
A 1 74  ASP 74  92   92   ASP ASP A . n 
A 1 75  LEU 75  93   93   LEU LEU A . n 
A 1 76  LYS 76  94   94   LYS LYS A . n 
A 1 77  ARG 77  95   95   ARG ARG A . n 
A 1 78  GLN 78  96   96   GLN GLN A . n 
A 1 79  PHE 79  97   97   PHE PHE A . n 
A 1 80  LYS 80  98   98   LYS LYS A . n 
A 1 81  ALA 81  99   99   ALA ALA A . n 
A 1 82  LEU 82  100  100  LEU LEU A . n 
A 1 83  THR 83  101  101  THR THR A . n 
A 1 84  LYS 84  102  102  LYS LYS A . n 
A 1 85  LEU 85  103  103  LEU LEU A . n 
A 1 86  GLY 86  104  104  GLY GLY A . n 
A 1 87  TYR 87  105  105  TYR TYR A . n 
A 1 88  ALA 88  106  106  ALA ALA A . n 
A 1 89  ALA 89  107  107  ALA ALA A . n 
A 1 90  LEU 90  108  108  LEU LEU A . n 
A 1 91  PRO 91  109  109  PRO PRO A . n 
A 1 92  GLU 92  110  110  GLU GLU A . n 
A 1 93  ASP 93  111  111  ASP ASP A . n 
A 1 94  ASP 94  112  112  ASP ASP A . n 
A 1 95  TYR 95  113  113  TYR TYR A . n 
A 1 96  ALA 96  114  114  ALA ALA A . n 
A 1 97  GLU 97  115  115  GLU GLU A . n 
A 1 98  LEU 98  116  116  LEU LEU A . n 
A 1 99  LEU 99  117  117  LEU LEU A . n 
A 1 100 ASP 100 118  118  ASP ASP A . n 
A 1 101 THR 101 119  119  THR THR A . n 
A 1 102 LEU 102 120  120  LEU LEU A . n 
A 1 103 SER 103 121  121  SER SER A . n 
A 1 104 ALA 104 122  122  ALA ALA A . n 
A 1 105 MET 105 123  123  MET MET A . n 
A 1 106 GLU 106 124  124  GLU GLU A . n 
A 1 107 SER 107 125  125  SER SER A . n 
A 1 108 ASN 108 126  126  ASN ASN A . n 
A 1 109 PHE 109 127  127  PHE PHE A . n 
A 1 110 ALA 110 128  128  ALA ALA A . n 
A 1 111 LYS 111 129  129  LYS LYS A . n 
A 1 112 VAL 112 130  130  VAL VAL A . n 
A 1 113 LYS 113 131  131  LYS LYS A . n 
A 1 114 VAL 114 132  132  VAL VAL A . n 
A 1 115 CYS 115 133  133  CYS CYS A . n 
A 1 116 ASP 116 134  134  ASP ASP A . n 
A 1 117 TYR 117 135  135  TYR TYR A . n 
A 1 118 LYS 118 136  136  LYS LYS A . n 
A 1 119 ASP 119 137  137  ASP ASP A . n 
A 1 120 SER 120 138  138  SER SER A . n 
A 1 121 THR 121 139  139  THR THR A . n 
A 1 122 LYS 122 140  140  LYS LYS A . n 
A 1 123 CYS 123 141  141  CYS CYS A . n 
A 1 124 ASP 124 142  142  ASP ASP A . n 
A 1 125 LEU 125 143  143  LEU LEU A . n 
A 1 126 ALA 126 144  144  ALA ALA A . n 
A 1 127 LEU 127 145  145  LEU LEU A . n 
A 1 128 ASP 128 146  146  ASP ASP A . n 
A 1 129 PRO 129 147  147  PRO PRO A . n 
A 1 130 GLU 130 148  148  GLU GLU A . n 
A 1 131 ILE 131 149  149  ILE ILE A . n 
A 1 132 GLU 132 150  150  GLU GLU A . n 
A 1 133 GLU 133 151  151  GLU GLU A . n 
A 1 134 VAL 134 152  152  VAL VAL A . n 
A 1 135 ILE 135 153  153  ILE ILE A . n 
A 1 136 SER 136 154  154  SER SER A . n 
A 1 137 LYS 137 155  155  LYS LYS A . n 
A 1 138 SER 138 156  156  SER SER A . n 
A 1 139 ARG 139 157  157  ARG ARG A . n 
A 1 140 ASP 140 158  158  ASP ASP A . n 
A 1 141 HIS 141 159  159  HIS HIS A . n 
A 1 142 GLU 142 160  160  GLU GLU A . n 
A 1 143 GLU 143 161  161  GLU GLU A . n 
A 1 144 LEU 144 162  162  LEU LEU A . n 
A 1 145 ALA 145 163  163  ALA ALA A . n 
A 1 146 TYR 146 164  164  TYR TYR A . n 
A 1 147 TYR 147 165  165  TYR TYR A . n 
A 1 148 TRP 148 166  166  TRP TRP A . n 
A 1 149 ARG 149 167  167  ARG ARG A . n 
A 1 150 GLU 150 168  168  GLU GLU A . n 
A 1 151 PHE 151 169  169  PHE PHE A . n 
A 1 152 TYR 152 170  170  TYR TYR A . n 
A 1 153 ASP 153 171  171  ASP ASP A . n 
A 1 154 LYS 154 172  172  LYS LYS A . n 
A 1 155 ALA 155 173  173  ALA ALA A . n 
A 1 156 GLY 156 174  174  GLY GLY A . n 
A 1 157 THR 157 175  175  THR THR A . n 
A 1 158 ALA 158 176  176  ALA ALA A . n 
A 1 159 VAL 159 177  177  VAL VAL A . n 
A 1 160 ARG 160 178  178  ARG ARG A . n 
A 1 161 SER 161 179  179  SER SER A . n 
A 1 162 GLN 162 180  180  GLN GLN A . n 
A 1 163 PHE 163 181  181  PHE PHE A . n 
A 1 164 GLU 164 182  182  GLU GLU A . n 
A 1 165 ARG 165 183  183  ARG ARG A . n 
A 1 166 TYR 166 184  184  TYR TYR A . n 
A 1 167 VAL 167 185  185  VAL VAL A . n 
A 1 168 GLU 168 186  186  GLU GLU A . n 
A 1 169 LEU 169 187  187  LEU LEU A . n 
A 1 170 ASN 170 188  188  ASN ASN A . n 
A 1 171 THR 171 189  189  THR THR A . n 
A 1 172 LYS 172 190  190  LYS LYS A . n 
A 1 173 ALA 173 191  191  ALA ALA A . n 
A 1 174 ALA 174 192  192  ALA ALA A . n 
A 1 175 LYS 175 193  193  LYS LYS A . n 
A 1 176 LEU 176 194  194  LEU LEU A . n 
A 1 177 ASN 177 195  195  ASN ASN A . n 
A 1 178 ASN 178 196  196  ASN ASN A . n 
A 1 179 PHE 179 197  197  PHE PHE A . n 
A 1 180 THR 180 198  198  THR THR A . n 
A 1 181 SER 181 199  199  SER SER A . n 
A 1 182 GLY 182 200  200  GLY GLY A . n 
A 1 183 ALA 183 201  201  ALA ALA A . n 
A 1 184 GLU 184 202  202  GLU GLU A . n 
A 1 185 ALA 185 203  203  ALA ALA A . n 
A 1 186 TRP 186 204  204  TRP TRP A . n 
A 1 187 LEU 187 205  205  LEU LEU A . n 
A 1 188 ASP 188 206  206  ASP ASP A . n 
A 1 189 GLU 189 207  207  GLU GLU A . n 
A 1 190 TYR 190 208  208  TYR TYR A . n 
A 1 191 GLU 191 209  209  GLU GLU A . n 
A 1 192 ASP 192 210  210  ASP ASP A . n 
A 1 193 ASP 193 211  211  ASP ASP A . n 
A 1 194 THR 194 212  212  THR THR A . n 
A 1 195 PHE 195 213  213  PHE PHE A . n 
A 1 196 GLU 196 214  214  GLU GLU A . n 
A 1 197 GLN 197 215  215  GLN GLN A . n 
A 1 198 GLN 198 216  216  GLN GLN A . n 
A 1 199 LEU 199 217  217  LEU LEU A . n 
A 1 200 GLU 200 218  218  GLU GLU A . n 
A 1 201 ASP 201 219  219  ASP ASP A . n 
A 1 202 ILE 202 220  220  ILE ILE A . n 
A 1 203 PHE 203 221  221  PHE PHE A . n 
A 1 204 ALA 204 222  222  ALA ALA A . n 
A 1 205 ASP 205 223  223  ASP ASP A . n 
A 1 206 ILE 206 224  224  ILE ILE A . n 
A 1 207 ARG 207 225  225  ARG ARG A . n 
A 1 208 PRO 208 226  226  PRO PRO A . n 
A 1 209 LEU 209 227  227  LEU LEU A . n 
A 1 210 TYR 210 228  228  TYR TYR A . n 
A 1 211 GLN 211 229  229  GLN GLN A . n 
A 1 212 GLN 212 230  230  GLN GLN A . n 
A 1 213 ILE 213 231  231  ILE ILE A . n 
A 1 214 HIS 214 232  232  HIS HIS A . n 
A 1 215 GLY 215 233  233  GLY GLY A . n 
A 1 216 TYR 216 234  234  TYR TYR A . n 
A 1 217 VAL 217 235  235  VAL VAL A . n 
A 1 218 ARG 218 236  236  ARG ARG A . n 
A 1 219 PHE 219 237  237  PHE PHE A . n 
A 1 220 ARG 220 238  238  ARG ARG A . n 
A 1 221 LEU 221 239  239  LEU LEU A . n 
A 1 222 ARG 222 240  240  ARG ARG A . n 
A 1 223 LYS 223 241  241  LYS LYS A . n 
A 1 224 HIS 224 242  242  HIS HIS A . n 
A 1 225 TYR 225 243  243  TYR TYR A . n 
A 1 226 GLY 226 244  244  GLY GLY A . n 
A 1 227 ASP 227 245  245  ASP ASP A . n 
A 1 228 ALA 228 246  246  ALA ALA A . n 
A 1 229 VAL 229 247  247  VAL VAL A . n 
A 1 230 VAL 230 248  248  VAL VAL A . n 
A 1 231 SER 231 249  249  SER SER A . n 
A 1 232 GLU 232 250  250  GLU GLU A . n 
A 1 233 THR 233 251  251  THR THR A . n 
A 1 234 GLY 234 252  252  GLY GLY A . n 
A 1 235 PRO 235 253  253  PRO PRO A . n 
A 1 236 ILE 236 254  254  ILE ILE A . n 
A 1 237 PRO 237 255  255  PRO PRO A . n 
A 1 238 MET 238 256  256  MET MET A . n 
A 1 239 HIS 239 257  257  HIS HIS A . n 
A 1 240 LEU 240 258  258  LEU LEU A . n 
A 1 241 LEU 241 259  259  LEU LEU A . n 
A 1 242 GLY 242 260  260  GLY GLY A . n 
A 1 243 ASN 243 261  261  ASN ASN A . n 
A 1 244 MET 244 262  262  MET MET A . n 
A 1 245 TRP 245 263  263  TRP TRP A . n 
A 1 246 ALA 246 264  264  ALA ALA A . n 
A 1 247 GLN 247 265  265  GLN GLN A . n 
A 1 248 GLN 248 266  266  GLN GLN A . n 
A 1 249 TRP 249 267  267  TRP TRP A . n 
A 1 250 SER 250 268  268  SER SER A . n 
A 1 251 GLU 251 269  269  GLU GLU A . n 
A 1 252 ILE 252 270  270  ILE ILE A . n 
A 1 253 ALA 253 271  271  ALA ALA A . n 
A 1 254 ASP 254 272  272  ASP ASP A . n 
A 1 255 ILE 255 273  273  ILE ILE A . n 
A 1 256 VAL 256 274  274  VAL VAL A . n 
A 1 257 SER 257 275  275  SER SER A . n 
A 1 258 PRO 258 276  276  PRO PRO A . n 
A 1 259 PHE 259 277  277  PHE PHE A . n 
A 1 260 PRO 260 278  278  PRO PRO A . n 
A 1 261 GLU 261 279  279  GLU GLU A . n 
A 1 262 LYS 262 280  280  LYS LYS A . n 
A 1 263 PRO 263 281  281  PRO PRO A . n 
A 1 264 LEU 264 282  282  LEU LEU A . n 
A 1 265 VAL 265 283  283  VAL VAL A . n 
A 1 266 ASP 266 284  284  ASP ASP A . n 
A 1 267 VAL 267 285  285  VAL VAL A . n 
A 1 268 SER 268 286  286  SER SER A . n 
A 1 269 ALA 269 287  287  ALA ALA A . n 
A 1 270 GLU 270 288  288  GLU GLU A . n 
A 1 271 MET 271 289  289  MET MET A . n 
A 1 272 GLU 272 290  290  GLU GLU A . n 
A 1 273 LYS 273 291  291  LYS LYS A . n 
A 1 274 GLN 274 292  292  GLN GLN A . n 
A 1 275 GLY 275 293  293  GLY GLY A . n 
A 1 276 TYR 276 294  294  TYR TYR A . n 
A 1 277 THR 277 295  295  THR THR A . n 
A 1 278 PRO 278 296  296  PRO PRO A . n 
A 1 279 LEU 279 297  297  LEU LEU A . n 
A 1 280 LYS 280 298  298  LYS LYS A . n 
A 1 281 MET 281 299  299  MET MET A . n 
A 1 282 PHE 282 300  300  PHE PHE A . n 
A 1 283 GLN 283 301  301  GLN GLN A . n 
A 1 284 MET 284 302  302  MET MET A . n 
A 1 285 GLY 285 303  303  GLY GLY A . n 
A 1 286 ASP 286 304  304  ASP ASP A . n 
A 1 287 ASP 287 305  305  ASP ASP A . n 
A 1 288 PHE 288 306  306  PHE PHE A . n 
A 1 289 PHE 289 307  307  PHE PHE A . n 
A 1 290 THR 290 308  308  THR THR A . n 
A 1 291 SER 291 309  309  SER SER A . n 
A 1 292 MET 292 310  310  MET MET A . n 
A 1 293 ASN 293 311  311  ASN ASN A . n 
A 1 294 LEU 294 312  312  LEU LEU A . n 
A 1 295 THR 295 313  313  THR THR A . n 
A 1 296 LYS 296 314  314  LYS LYS A . n 
A 1 297 LEU 297 315  315  LEU LEU A . n 
A 1 298 PRO 298 316  316  PRO PRO A . n 
A 1 299 GLN 299 317  317  GLN GLN A . n 
A 1 300 ASP 300 318  318  ASP ASP A . n 
A 1 301 PHE 301 319  319  PHE PHE A . n 
A 1 302 TRP 302 320  320  TRP TRP A . n 
A 1 303 ASP 303 321  321  ASP ASP A . n 
A 1 304 LYS 304 322  322  LYS LYS A . n 
A 1 305 SER 305 323  323  SER SER A . n 
A 1 306 ILE 306 324  324  ILE ILE A . n 
A 1 307 ILE 307 325  325  ILE ILE A . n 
A 1 308 GLU 308 326  326  GLU GLU A . n 
A 1 309 LYS 309 327  327  LYS LYS A . n 
A 1 310 PRO 310 328  328  PRO PRO A . n 
A 1 311 THR 311 329  329  THR THR A . n 
A 1 312 ASP 312 330  330  ASP ASP A . n 
A 1 313 GLY 313 331  331  GLY GLY A . n 
A 1 314 ARG 314 332  332  ARG ARG A . n 
A 1 315 ASP 315 333  333  ASP ASP A . n 
A 1 316 LEU 316 334  334  LEU LEU A . n 
A 1 317 VAL 317 335  335  VAL VAL A . n 
A 1 318 CYS 318 336  336  CYS CYS A . n 
A 1 319 HIS 319 337  337  HIS HIS A . n 
A 1 320 ALA 320 338  338  ALA ALA A . n 
A 1 321 SER 321 339  339  SER SER A . n 
A 1 322 ALA 322 340  340  ALA ALA A . n 
A 1 323 TRP 323 341  341  TRP TRP A . n 
A 1 324 ASP 324 342  342  ASP ASP A . n 
A 1 325 PHE 325 343  343  PHE PHE A . n 
A 1 326 TYR 326 344  344  TYR TYR A . n 
A 1 327 LEU 327 345  345  LEU LEU A . n 
A 1 328 ILE 328 346  346  ILE ILE A . n 
A 1 329 ASP 329 347  347  ASP ASP A . n 
A 1 330 ASP 330 348  348  ASP ASP A . n 
A 1 331 VAL 331 349  349  VAL VAL A . n 
A 1 332 ARG 332 350  350  ARG ARG A . n 
A 1 333 ILE 333 351  351  ILE ILE A . n 
A 1 334 LYS 334 352  352  LYS LYS A . n 
A 1 335 GLN 335 353  353  GLN GLN A . n 
A 1 336 CYS 336 354  354  CYS CYS A . n 
A 1 337 THR 337 355  355  THR THR A . n 
A 1 338 ARG 338 356  356  ARG ARG A . n 
A 1 339 VAL 339 357  357  VAL VAL A . n 
A 1 340 THR 340 358  358  THR THR A . n 
A 1 341 GLN 341 359  359  GLN GLN A . n 
A 1 342 ASP 342 360  360  ASP ASP A . n 
A 1 343 GLN 343 361  361  GLN GLN A . n 
A 1 344 LEU 344 362  362  LEU LEU A . n 
A 1 345 PHE 345 363  363  PHE PHE A . n 
A 1 346 THR 346 364  364  THR THR A . n 
A 1 347 VAL 347 365  365  VAL VAL A . n 
A 1 348 HIS 348 366  366  HIS HIS A . n 
A 1 349 HIS 349 367  367  HIS HIS A . n 
A 1 350 GLU 350 368  368  GLU GLU A . n 
A 1 351 LEU 351 369  369  LEU LEU A . n 
A 1 352 GLY 352 370  370  GLY GLY A . n 
A 1 353 HIS 353 371  371  HIS HIS A . n 
A 1 354 ILE 354 372  372  ILE ILE A . n 
A 1 355 GLN 355 373  373  GLN GLN A . n 
A 1 356 TYR 356 374  374  TYR TYR A . n 
A 1 357 PHE 357 375  375  PHE PHE A . n 
A 1 358 LEU 358 376  376  LEU LEU A . n 
A 1 359 GLN 359 377  377  GLN GLN A . n 
A 1 360 TYR 360 378  378  TYR TYR A . n 
A 1 361 GLN 361 379  379  GLN GLN A . n 
A 1 362 HIS 362 380  380  HIS HIS A . n 
A 1 363 GLN 363 381  381  GLN GLN A . n 
A 1 364 PRO 364 382  382  PRO PRO A . n 
A 1 365 PHE 365 383  383  PHE PHE A . n 
A 1 366 VAL 366 384  384  VAL VAL A . n 
A 1 367 TYR 367 385  385  TYR TYR A . n 
A 1 368 ARG 368 386  386  ARG ARG A . n 
A 1 369 THR 369 387  387  THR THR A . n 
A 1 370 GLY 370 388  388  GLY GLY A . n 
A 1 371 ALA 371 389  389  ALA ALA A . n 
A 1 372 ASN 372 390  390  ASN ASN A . n 
A 1 373 PRO 373 391  391  PRO PRO A . n 
A 1 374 GLY 374 392  392  GLY GLY A . n 
A 1 375 PHE 375 393  393  PHE PHE A . n 
A 1 376 HIS 376 394  394  HIS HIS A . n 
A 1 377 GLU 377 395  395  GLU GLU A . n 
A 1 378 ALA 378 396  396  ALA ALA A . n 
A 1 379 VAL 379 397  397  VAL VAL A . n 
A 1 380 GLY 380 398  398  GLY GLY A . n 
A 1 381 ASP 381 399  399  ASP ASP A . n 
A 1 382 VAL 382 400  400  VAL VAL A . n 
A 1 383 LEU 383 401  401  LEU LEU A . n 
A 1 384 SER 384 402  402  SER SER A . n 
A 1 385 LEU 385 403  403  LEU LEU A . n 
A 1 386 SER 386 404  404  SER SER A . n 
A 1 387 VAL 387 405  405  VAL VAL A . n 
A 1 388 SER 388 406  406  SER SER A . n 
A 1 389 THR 389 407  407  THR THR A . n 
A 1 390 PRO 390 408  408  PRO PRO A . n 
A 1 391 LYS 391 409  409  LYS LYS A . n 
A 1 392 HIS 392 410  410  HIS HIS A . n 
A 1 393 LEU 393 411  411  LEU LEU A . n 
A 1 394 GLU 394 412  412  GLU GLU A . n 
A 1 395 LYS 395 413  413  LYS LYS A . n 
A 1 396 ILE 396 414  414  ILE ILE A . n 
A 1 397 GLY 397 415  415  GLY GLY A . n 
A 1 398 LEU 398 416  416  LEU LEU A . n 
A 1 399 LEU 399 417  417  LEU LEU A . n 
A 1 400 LYS 400 418  418  LYS LYS A . n 
A 1 401 ASP 401 419  419  ASP ASP A . n 
A 1 402 TYR 402 420  420  TYR TYR A . n 
A 1 403 VAL 403 421  421  VAL VAL A . n 
A 1 404 ARG 404 422  422  ARG ARG A . n 
A 1 405 ASP 405 423  423  ASP ASP A . n 
A 1 406 ASP 406 424  424  ASP ASP A . n 
A 1 407 GLU 407 425  425  GLU GLU A . n 
A 1 408 ALA 408 426  426  ALA ALA A . n 
A 1 409 ARG 409 427  427  ARG ARG A . n 
A 1 410 ILE 410 428  428  ILE ILE A . n 
A 1 411 ASN 411 429  429  ASN ASN A . n 
A 1 412 GLN 412 430  430  GLN GLN A . n 
A 1 413 LEU 413 431  431  LEU LEU A . n 
A 1 414 PHE 414 432  432  PHE PHE A . n 
A 1 415 LEU 415 433  433  LEU LEU A . n 
A 1 416 THR 416 434  434  THR THR A . n 
A 1 417 ALA 417 435  435  ALA ALA A . n 
A 1 418 LEU 418 436  436  LEU LEU A . n 
A 1 419 ASP 419 437  437  ASP ASP A . n 
A 1 420 LYS 420 438  438  LYS LYS A . n 
A 1 421 ILE 421 439  439  ILE ILE A . n 
A 1 422 VAL 422 440  440  VAL VAL A . n 
A 1 423 PHE 423 441  441  PHE PHE A . n 
A 1 424 LEU 424 442  442  LEU LEU A . n 
A 1 425 PRO 425 443  443  PRO PRO A . n 
A 1 426 PHE 426 444  444  PHE PHE A . n 
A 1 427 ALA 427 445  445  ALA ALA A . n 
A 1 428 PHE 428 446  446  PHE PHE A . n 
A 1 429 THR 429 447  447  THR THR A . n 
A 1 430 MET 430 448  448  MET MET A . n 
A 1 431 ASP 431 449  449  ASP ASP A . n 
A 1 432 LYS 432 450  450  LYS LYS A . n 
A 1 433 TYR 433 451  451  TYR TYR A . n 
A 1 434 ARG 434 452  452  ARG ARG A . n 
A 1 435 TRP 435 453  453  TRP TRP A . n 
A 1 436 SER 436 454  454  SER SER A . n 
A 1 437 LEU 437 455  455  LEU LEU A . n 
A 1 438 PHE 438 456  456  PHE PHE A . n 
A 1 439 ARG 439 457  457  ARG ARG A . n 
A 1 440 GLY 440 458  458  GLY GLY A . n 
A 1 441 GLU 441 459  459  GLU GLU A . n 
A 1 442 VAL 442 460  460  VAL VAL A . n 
A 1 443 ASP 443 461  461  ASP ASP A . n 
A 1 444 LYS 444 462  462  LYS LYS A . n 
A 1 445 ALA 445 463  463  ALA ALA A . n 
A 1 446 ASN 446 464  464  ASN ASN A . n 
A 1 447 TRP 447 465  465  TRP TRP A . n 
A 1 448 ASN 448 466  466  ASN ASN A . n 
A 1 449 CYS 449 467  467  CYS CYS A . n 
A 1 450 ALA 450 468  468  ALA ALA A . n 
A 1 451 PHE 451 469  469  PHE PHE A . n 
A 1 452 TRP 452 470  470  TRP TRP A . n 
A 1 453 LYS 453 471  471  LYS LYS A . n 
A 1 454 LEU 454 472  472  LEU LEU A . n 
A 1 455 ARG 455 473  473  ARG ARG A . n 
A 1 456 ASP 456 474  474  ASP ASP A . n 
A 1 457 GLU 457 475  475  GLU GLU A . n 
A 1 458 TYR 458 476  476  TYR TYR A . n 
A 1 459 SER 459 477  477  SER SER A . n 
A 1 460 GLY 460 478  478  GLY GLY A . n 
A 1 461 ILE 461 479  479  ILE ILE A . n 
A 1 462 GLU 462 480  480  GLU GLU A . n 
A 1 463 PRO 463 481  481  PRO PRO A . n 
A 1 464 PRO 464 482  482  PRO PRO A . n 
A 1 465 VAL 465 483  483  VAL VAL A . n 
A 1 466 VAL 466 484  484  VAL VAL A . n 
A 1 467 ARG 467 485  485  ARG ARG A . n 
A 1 468 SER 468 486  486  SER SER A . n 
A 1 469 GLU 469 487  487  GLU GLU A . n 
A 1 470 LYS 470 488  488  LYS LYS A . n 
A 1 471 ASP 471 489  489  ASP ASP A . n 
A 1 472 PHE 472 490  490  PHE PHE A . n 
A 1 473 ASP 473 491  491  ASP ASP A . n 
A 1 474 ALA 474 492  492  ALA ALA A . n 
A 1 475 PRO 475 493  493  PRO PRO A . n 
A 1 476 ALA 476 494  494  ALA ALA A . n 
A 1 477 LYS 477 495  495  LYS LYS A . n 
A 1 478 TYR 478 496  496  TYR TYR A . n 
A 1 479 HIS 479 497  497  HIS HIS A . n 
A 1 480 ILE 480 498  498  ILE ILE A . n 
A 1 481 SER 481 499  499  SER SER A . n 
A 1 482 ALA 482 500  500  ALA ALA A . n 
A 1 483 ASP 483 501  501  ASP ASP A . n 
A 1 484 VAL 484 502  502  VAL VAL A . n 
A 1 485 GLU 485 503  503  GLU GLU A . n 
A 1 486 TYR 486 504  504  TYR TYR A . n 
A 1 487 LEU 487 505  505  LEU LEU A . n 
A 1 488 ARG 488 506  506  ARG ARG A . n 
A 1 489 TYR 489 507  507  TYR TYR A . n 
A 1 490 LEU 490 508  508  LEU LEU A . n 
A 1 491 VAL 491 509  509  VAL VAL A . n 
A 1 492 SER 492 510  510  SER SER A . n 
A 1 493 PHE 493 511  511  PHE PHE A . n 
A 1 494 ILE 494 512  512  ILE ILE A . n 
A 1 495 ILE 495 513  513  ILE ILE A . n 
A 1 496 GLN 496 514  514  GLN GLN A . n 
A 1 497 PHE 497 515  515  PHE PHE A . n 
A 1 498 GLN 498 516  516  GLN GLN A . n 
A 1 499 PHE 499 517  517  PHE PHE A . n 
A 1 500 TYR 500 518  518  TYR TYR A . n 
A 1 501 LYS 501 519  519  LYS LYS A . n 
A 1 502 SER 502 520  520  SER SER A . n 
A 1 503 ALA 503 521  521  ALA ALA A . n 
A 1 504 CYS 504 522  522  CYS CYS A . n 
A 1 505 ILE 505 523  523  ILE ILE A . n 
A 1 506 LYS 506 524  524  LYS LYS A . n 
A 1 507 ALA 507 525  525  ALA ALA A . n 
A 1 508 GLY 508 526  526  GLY GLY A . n 
A 1 509 GLN 509 527  527  GLN GLN A . n 
A 1 510 TYR 510 528  528  TYR TYR A . n 
A 1 511 ASP 511 529  529  ASP ASP A . n 
A 1 512 PRO 512 530  530  PRO PRO A . n 
A 1 513 ASP 513 531  531  ASP ASP A . n 
A 1 514 ASN 514 532  532  ASN ASN A . n 
A 1 515 VAL 515 533  533  VAL VAL A . n 
A 1 516 GLU 516 534  534  GLU GLU A . n 
A 1 517 LEU 517 535  535  LEU LEU A . n 
A 1 518 PRO 518 536  536  PRO PRO A . n 
A 1 519 LEU 519 537  537  LEU LEU A . n 
A 1 520 ASP 520 538  538  ASP ASP A . n 
A 1 521 ASN 521 539  539  ASN ASN A . n 
A 1 522 CYS 522 540  540  CYS CYS A . n 
A 1 523 ASP 523 541  541  ASP ASP A . n 
A 1 524 ILE 524 542  542  ILE ILE A . n 
A 1 525 TYR 525 543  543  TYR TYR A . n 
A 1 526 GLY 526 544  544  GLY GLY A . n 
A 1 527 SER 527 545  545  SER SER A . n 
A 1 528 ALA 528 546  546  ALA ALA A . n 
A 1 529 ALA 529 547  547  ALA ALA A . n 
A 1 530 ALA 530 548  548  ALA ALA A . n 
A 1 531 GLY 531 549  549  GLY GLY A . n 
A 1 532 ALA 532 550  550  ALA ALA A . n 
A 1 533 ALA 533 551  551  ALA ALA A . n 
A 1 534 PHE 534 552  552  PHE PHE A . n 
A 1 535 HIS 535 553  553  HIS HIS A . n 
A 1 536 ASN 536 554  554  ASN ASN A . n 
A 1 537 MET 537 555  555  MET MET A . n 
A 1 538 LEU 538 556  556  LEU LEU A . n 
A 1 539 SER 539 557  557  SER SER A . n 
A 1 540 MET 540 558  558  MET MET A . n 
A 1 541 GLY 541 559  559  GLY GLY A . n 
A 1 542 ALA 542 560  560  ALA ALA A . n 
A 1 543 SER 543 561  561  SER SER A . n 
A 1 544 LYS 544 562  562  LYS LYS A . n 
A 1 545 PRO 545 563  563  PRO PRO A . n 
A 1 546 TRP 546 564  564  TRP TRP A . n 
A 1 547 PRO 547 565  565  PRO PRO A . n 
A 1 548 ASP 548 566  566  ASP ASP A . n 
A 1 549 ALA 549 567  567  ALA ALA A . n 
A 1 550 LEU 550 568  568  LEU LEU A . n 
A 1 551 GLU 551 569  569  GLU GLU A . n 
A 1 552 ALA 552 570  570  ALA ALA A . n 
A 1 553 PHE 553 571  571  PHE PHE A . n 
A 1 554 ASN 554 572  572  ASN ASN A . n 
A 1 555 GLY 555 573  573  GLY GLY A . n 
A 1 556 GLU 556 574  574  GLU GLU A . n 
A 1 557 ARG 557 575  575  ARG ARG A . n 
A 1 558 ILE 558 576  576  ILE ILE A . n 
A 1 559 MET 559 577  577  MET MET A . n 
A 1 560 SER 560 578  578  SER SER A . n 
A 1 561 GLY 561 579  579  GLY GLY A . n 
A 1 562 LYS 562 580  580  LYS LYS A . n 
A 1 563 ALA 563 581  581  ALA ALA A . n 
A 1 564 ILE 564 582  582  ILE ILE A . n 
A 1 565 ALA 565 583  583  ALA ALA A . n 
A 1 566 GLU 566 584  584  GLU GLU A . n 
A 1 567 TYR 567 585  585  TYR TYR A . n 
A 1 568 PHE 568 586  586  PHE PHE A . n 
A 1 569 GLU 569 587  587  GLU GLU A . n 
A 1 570 PRO 570 588  588  PRO PRO A . n 
A 1 571 LEU 571 589  589  LEU LEU A . n 
A 1 572 ARG 572 590  590  ARG ARG A . n 
A 1 573 VAL 573 591  591  VAL VAL A . n 
A 1 574 TRP 574 592  592  TRP TRP A . n 
A 1 575 LEU 575 593  593  LEU LEU A . n 
A 1 576 GLU 576 594  594  GLU GLU A . n 
A 1 577 ALA 577 595  595  ALA ALA A . n 
A 1 578 GLU 578 596  596  GLU GLU A . n 
A 1 579 ASN 579 597  597  ASN ASN A . n 
A 1 580 ILE 580 598  598  ILE ILE A . n 
A 1 581 LYS 581 599  599  LYS LYS A . n 
A 1 582 ASN 582 600  600  ASN ASN A . n 
A 1 583 ASN 583 601  601  ASN ASN A . n 
A 1 584 VAL 584 602  602  VAL VAL A . n 
A 1 585 HIS 585 603  603  HIS HIS A . n 
A 1 586 ILE 586 604  604  ILE ILE A . n 
A 1 587 GLY 587 605  605  GLY GLY A . n 
A 1 588 TRP 588 606  606  TRP TRP A . n 
A 1 589 THR 589 607  607  THR THR A . n 
A 1 590 THR 590 608  608  THR THR A . n 
A 1 591 SER 591 609  609  SER SER A . n 
A 1 592 ASN 592 610  610  ASN ASN A . n 
A 1 593 LYS 593 611  611  LYS LYS A . n 
A 1 594 CYS 594 612  612  CYS CYS A . n 
A 1 595 VAL 595 613  613  VAL VAL A . n 
A 1 596 SER 596 614  614  SER SER A . n 
B 2 1   VAL 1   1701 1701 VAL VAL B . n 
B 2 2   TRP 2   1702 1702 TRP TRP B . n 
C 2 1   VAL 1   1629 1629 VAL VAL D . n 
C 2 2   TRP 2   1630 1630 TRP TRP D . n 
# 
loop_
_pdbx_branch_scheme.asym_id 
_pdbx_branch_scheme.entity_id 
_pdbx_branch_scheme.mon_id 
_pdbx_branch_scheme.num 
_pdbx_branch_scheme.pdb_asym_id 
_pdbx_branch_scheme.pdb_mon_id 
_pdbx_branch_scheme.pdb_seq_num 
_pdbx_branch_scheme.auth_asym_id 
_pdbx_branch_scheme.auth_mon_id 
_pdbx_branch_scheme.auth_seq_num 
_pdbx_branch_scheme.hetero 
D 3 NAG 1 C NAG 1 A NAG 1623 n 
D 3 NAG 2 C NAG 2 A NAG 1624 n 
D 3 BMA 3 C BMA 3 A BMA 1625 n 
D 3 MAN 4 C MAN 4 A MAN 1627 n 
D 3 BMA 5 C BMA 5 A BMA 1628 n 
D 3 MAN 6 C MAN 6 A MAN 1626 n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        ZN 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   ZN 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
E 4 ZN  1   701  1616 ZN  ZN  A . 
F 5 NAG 1   702  1621 NAG NAG A . 
G 5 NAG 1   703  1622 NAG NAG A . 
H 6 HOH 1   801  12   HOH HOH A . 
H 6 HOH 2   802  152  HOH HOH A . 
H 6 HOH 3   803  222  HOH HOH A . 
H 6 HOH 4   804  223  HOH HOH A . 
H 6 HOH 5   805  51   HOH HOH A . 
H 6 HOH 6   806  47   HOH HOH A . 
H 6 HOH 7   807  165  HOH HOH A . 
H 6 HOH 8   808  98   HOH HOH A . 
H 6 HOH 9   809  235  HOH HOH A . 
H 6 HOH 10  810  191  HOH HOH A . 
H 6 HOH 11  811  42   HOH HOH A . 
H 6 HOH 12  812  151  HOH HOH A . 
H 6 HOH 13  813  105  HOH HOH A . 
H 6 HOH 14  814  54   HOH HOH A . 
H 6 HOH 15  815  103  HOH HOH A . 
H 6 HOH 16  816  147  HOH HOH A . 
H 6 HOH 17  817  84   HOH HOH A . 
H 6 HOH 18  818  39   HOH HOH A . 
H 6 HOH 19  819  63   HOH HOH A . 
H 6 HOH 20  820  117  HOH HOH A . 
H 6 HOH 21  821  72   HOH HOH A . 
H 6 HOH 22  822  37   HOH HOH A . 
H 6 HOH 23  823  88   HOH HOH A . 
H 6 HOH 24  824  215  HOH HOH A . 
H 6 HOH 25  825  160  HOH HOH A . 
H 6 HOH 26  826  73   HOH HOH A . 
H 6 HOH 27  827  62   HOH HOH A . 
H 6 HOH 28  828  139  HOH HOH A . 
H 6 HOH 29  829  108  HOH HOH A . 
H 6 HOH 30  830  41   HOH HOH A . 
H 6 HOH 31  831  145  HOH HOH A . 
H 6 HOH 32  832  75   HOH HOH A . 
H 6 HOH 33  833  163  HOH HOH A . 
H 6 HOH 34  834  86   HOH HOH A . 
H 6 HOH 35  835  97   HOH HOH A . 
H 6 HOH 36  836  197  HOH HOH A . 
H 6 HOH 37  837  13   HOH HOH A . 
H 6 HOH 38  838  43   HOH HOH A . 
H 6 HOH 39  839  119  HOH HOH A . 
H 6 HOH 40  840  89   HOH HOH A . 
H 6 HOH 41  841  128  HOH HOH A . 
H 6 HOH 42  842  50   HOH HOH A . 
H 6 HOH 43  843  99   HOH HOH A . 
H 6 HOH 44  844  148  HOH HOH A . 
H 6 HOH 45  845  225  HOH HOH A . 
H 6 HOH 46  846  74   HOH HOH A . 
H 6 HOH 47  847  52   HOH HOH A . 
H 6 HOH 48  848  60   HOH HOH A . 
H 6 HOH 49  849  14   HOH HOH A . 
H 6 HOH 50  850  36   HOH HOH A . 
H 6 HOH 51  851  136  HOH HOH A . 
H 6 HOH 52  852  16   HOH HOH A . 
H 6 HOH 53  853  130  HOH HOH A . 
H 6 HOH 54  854  106  HOH HOH A . 
H 6 HOH 55  855  95   HOH HOH A . 
H 6 HOH 56  856  40   HOH HOH A . 
H 6 HOH 57  857  144  HOH HOH A . 
H 6 HOH 58  858  80   HOH HOH A . 
H 6 HOH 59  859  46   HOH HOH A . 
H 6 HOH 60  860  149  HOH HOH A . 
H 6 HOH 61  861  153  HOH HOH A . 
H 6 HOH 62  862  96   HOH HOH A . 
H 6 HOH 63  863  8    HOH HOH A . 
H 6 HOH 64  864  68   HOH HOH A . 
H 6 HOH 65  865  3    HOH HOH A . 
H 6 HOH 66  866  243  HOH HOH A . 
H 6 HOH 67  867  221  HOH HOH A . 
H 6 HOH 68  868  209  HOH HOH A . 
H 6 HOH 69  869  34   HOH HOH A . 
H 6 HOH 70  870  28   HOH HOH A . 
H 6 HOH 71  871  120  HOH HOH A . 
H 6 HOH 72  872  232  HOH HOH A . 
H 6 HOH 73  873  11   HOH HOH A . 
H 6 HOH 74  874  174  HOH HOH A . 
H 6 HOH 75  875  79   HOH HOH A . 
H 6 HOH 76  876  6    HOH HOH A . 
H 6 HOH 77  877  77   HOH HOH A . 
H 6 HOH 78  878  230  HOH HOH A . 
H 6 HOH 79  879  53   HOH HOH A . 
H 6 HOH 80  880  23   HOH HOH A . 
H 6 HOH 81  881  177  HOH HOH A . 
H 6 HOH 82  882  45   HOH HOH A . 
H 6 HOH 83  883  214  HOH HOH A . 
H 6 HOH 84  884  92   HOH HOH A . 
H 6 HOH 85  885  4    HOH HOH A . 
H 6 HOH 86  886  146  HOH HOH A . 
H 6 HOH 87  887  109  HOH HOH A . 
H 6 HOH 88  888  114  HOH HOH A . 
H 6 HOH 89  889  65   HOH HOH A . 
H 6 HOH 90  890  10   HOH HOH A . 
H 6 HOH 91  891  87   HOH HOH A . 
H 6 HOH 92  892  155  HOH HOH A . 
H 6 HOH 93  893  121  HOH HOH A . 
H 6 HOH 94  894  190  HOH HOH A . 
H 6 HOH 95  895  78   HOH HOH A . 
H 6 HOH 96  896  118  HOH HOH A . 
H 6 HOH 97  897  226  HOH HOH A . 
H 6 HOH 98  898  20   HOH HOH A . 
H 6 HOH 99  899  112  HOH HOH A . 
H 6 HOH 100 900  33   HOH HOH A . 
H 6 HOH 101 901  48   HOH HOH A . 
H 6 HOH 102 902  55   HOH HOH A . 
H 6 HOH 103 903  18   HOH HOH A . 
H 6 HOH 104 904  132  HOH HOH A . 
H 6 HOH 105 905  1    HOH HOH A . 
H 6 HOH 106 906  61   HOH HOH A . 
H 6 HOH 107 907  29   HOH HOH A . 
H 6 HOH 108 908  15   HOH HOH A . 
H 6 HOH 109 909  187  HOH HOH A . 
H 6 HOH 110 910  231  HOH HOH A . 
H 6 HOH 111 911  113  HOH HOH A . 
H 6 HOH 112 912  71   HOH HOH A . 
H 6 HOH 113 913  129  HOH HOH A . 
H 6 HOH 114 914  85   HOH HOH A . 
H 6 HOH 115 915  26   HOH HOH A . 
H 6 HOH 116 916  156  HOH HOH A . 
H 6 HOH 117 917  2    HOH HOH A . 
H 6 HOH 118 918  32   HOH HOH A . 
H 6 HOH 119 919  127  HOH HOH A . 
H 6 HOH 120 920  49   HOH HOH A . 
H 6 HOH 121 921  102  HOH HOH A . 
H 6 HOH 122 922  137  HOH HOH A . 
H 6 HOH 123 923  90   HOH HOH A . 
H 6 HOH 124 924  82   HOH HOH A . 
H 6 HOH 125 925  246  HOH HOH A . 
H 6 HOH 126 926  27   HOH HOH A . 
H 6 HOH 127 927  135  HOH HOH A . 
H 6 HOH 128 928  124  HOH HOH A . 
H 6 HOH 129 929  110  HOH HOH A . 
H 6 HOH 130 930  44   HOH HOH A . 
H 6 HOH 131 931  183  HOH HOH A . 
H 6 HOH 132 932  181  HOH HOH A . 
H 6 HOH 133 933  198  HOH HOH A . 
H 6 HOH 134 934  168  HOH HOH A . 
H 6 HOH 135 935  66   HOH HOH A . 
H 6 HOH 136 936  100  HOH HOH A . 
H 6 HOH 137 937  133  HOH HOH A . 
H 6 HOH 138 938  126  HOH HOH A . 
H 6 HOH 139 939  131  HOH HOH A . 
H 6 HOH 140 940  196  HOH HOH A . 
H 6 HOH 141 941  76   HOH HOH A . 
H 6 HOH 142 942  195  HOH HOH A . 
H 6 HOH 143 943  142  HOH HOH A . 
H 6 HOH 144 944  111  HOH HOH A . 
H 6 HOH 145 945  22   HOH HOH A . 
H 6 HOH 146 946  25   HOH HOH A . 
H 6 HOH 147 947  175  HOH HOH A . 
H 6 HOH 148 948  35   HOH HOH A . 
H 6 HOH 149 949  138  HOH HOH A . 
H 6 HOH 150 950  17   HOH HOH A . 
H 6 HOH 151 951  81   HOH HOH A . 
H 6 HOH 152 952  24   HOH HOH A . 
H 6 HOH 153 953  93   HOH HOH A . 
H 6 HOH 154 954  224  HOH HOH A . 
H 6 HOH 155 955  9    HOH HOH A . 
H 6 HOH 156 956  167  HOH HOH A . 
H 6 HOH 157 957  83   HOH HOH A . 
H 6 HOH 158 958  19   HOH HOH A . 
H 6 HOH 159 959  192  HOH HOH A . 
H 6 HOH 160 960  143  HOH HOH A . 
H 6 HOH 161 961  56   HOH HOH A . 
H 6 HOH 162 962  64   HOH HOH A . 
H 6 HOH 163 963  38   HOH HOH A . 
H 6 HOH 164 964  5    HOH HOH A . 
H 6 HOH 165 965  21   HOH HOH A . 
H 6 HOH 166 966  94   HOH HOH A . 
H 6 HOH 167 967  67   HOH HOH A . 
H 6 HOH 168 968  116  HOH HOH A . 
H 6 HOH 169 969  91   HOH HOH A . 
H 6 HOH 170 970  141  HOH HOH A . 
H 6 HOH 171 971  101  HOH HOH A . 
H 6 HOH 172 972  115  HOH HOH A . 
H 6 HOH 173 973  107  HOH HOH A . 
H 6 HOH 174 974  31   HOH HOH A . 
H 6 HOH 175 975  201  HOH HOH A . 
H 6 HOH 176 976  240  HOH HOH A . 
H 6 HOH 177 977  238  HOH HOH A . 
H 6 HOH 178 978  59   HOH HOH A . 
H 6 HOH 179 979  220  HOH HOH A . 
H 6 HOH 180 980  157  HOH HOH A . 
H 6 HOH 181 981  206  HOH HOH A . 
H 6 HOH 182 982  247  HOH HOH A . 
H 6 HOH 183 983  158  HOH HOH A . 
H 6 HOH 184 984  204  HOH HOH A . 
H 6 HOH 185 985  248  HOH HOH A . 
H 6 HOH 186 986  211  HOH HOH A . 
H 6 HOH 187 987  150  HOH HOH A . 
H 6 HOH 188 988  159  HOH HOH A . 
H 6 HOH 189 989  30   HOH HOH A . 
H 6 HOH 190 990  234  HOH HOH A . 
H 6 HOH 191 991  202  HOH HOH A . 
H 6 HOH 192 992  70   HOH HOH A . 
H 6 HOH 193 993  182  HOH HOH A . 
H 6 HOH 194 994  227  HOH HOH A . 
H 6 HOH 195 995  170  HOH HOH A . 
H 6 HOH 196 996  162  HOH HOH A . 
H 6 HOH 197 997  229  HOH HOH A . 
H 6 HOH 198 998  242  HOH HOH A . 
H 6 HOH 199 999  169  HOH HOH A . 
H 6 HOH 200 1000 213  HOH HOH A . 
H 6 HOH 201 1001 233  HOH HOH A . 
H 6 HOH 202 1002 210  HOH HOH A . 
H 6 HOH 203 1003 122  HOH HOH A . 
H 6 HOH 204 1004 104  HOH HOH A . 
H 6 HOH 205 1005 212  HOH HOH A . 
H 6 HOH 206 1006 219  HOH HOH A . 
H 6 HOH 207 1007 186  HOH HOH A . 
H 6 HOH 208 1008 207  HOH HOH A . 
H 6 HOH 209 1009 185  HOH HOH A . 
H 6 HOH 210 1010 200  HOH HOH A . 
H 6 HOH 211 1011 171  HOH HOH A . 
H 6 HOH 212 1012 140  HOH HOH A . 
H 6 HOH 213 1013 203  HOH HOH A . 
H 6 HOH 214 1014 239  HOH HOH A . 
H 6 HOH 215 1015 218  HOH HOH A . 
H 6 HOH 216 1016 193  HOH HOH A . 
H 6 HOH 217 1017 57   HOH HOH A . 
H 6 HOH 218 1018 176  HOH HOH A . 
H 6 HOH 219 1019 69   HOH HOH A . 
H 6 HOH 220 1020 199  HOH HOH A . 
H 6 HOH 221 1021 154  HOH HOH A . 
H 6 HOH 222 1022 245  HOH HOH A . 
H 6 HOH 223 1023 205  HOH HOH A . 
H 6 HOH 224 1024 134  HOH HOH A . 
H 6 HOH 225 1025 208  HOH HOH A . 
H 6 HOH 226 1026 244  HOH HOH A . 
H 6 HOH 227 1027 194  HOH HOH A . 
H 6 HOH 228 1028 237  HOH HOH A . 
H 6 HOH 229 1029 125  HOH HOH A . 
H 6 HOH 230 1030 228  HOH HOH A . 
H 6 HOH 231 1031 236  HOH HOH A . 
H 6 HOH 232 1032 172  HOH HOH A . 
H 6 HOH 233 1033 166  HOH HOH A . 
H 6 HOH 234 1034 173  HOH HOH A . 
H 6 HOH 235 1035 164  HOH HOH A . 
H 6 HOH 236 1036 217  HOH HOH A . 
H 6 HOH 237 1037 216  HOH HOH A . 
I 6 HOH 1   1801 178  HOH HOH B . 
I 6 HOH 2   1802 180  HOH HOH B . 
I 6 HOH 3   1803 189  HOH HOH B . 
J 6 HOH 1   1701 179  HOH HOH D . 
J 6 HOH 2   1702 241  HOH HOH D . 
J 6 HOH 3   1703 7    HOH HOH D . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? REFMAC  ? ? ? '5.8.0430 (refmacat 0.4.100)' 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? DIALS   ? ? ? .                             2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .                             3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .                             4 
# 
_cell.angle_alpha                  90 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9QA1 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     172.529 
_cell.length_a_esd                 ? 
_cell.length_b                     172.529 
_cell.length_b_esd                 ? 
_cell.length_c                     103.745 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        18 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9QA1 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                146 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'H 3' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9QA1 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             4.27 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          71.20 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '1.2 M sodium citrate, 0.1 M HEPES pH 7.5' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            289 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 XE 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-10-07 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.95 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'DIAMOND BEAMLINE I04' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.95 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   I04 
_diffrn_source.pdbx_synchrotron_site       Diamond 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9QA1 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.2 
_reflns.d_resolution_low                               43.17 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     58412 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                21.7 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          8.6 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                0.07 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.997 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.2 
_reflns_shell.d_res_low                                     2.26 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           1.4 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             4498 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               0.848 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.824 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            -2.196 
_refine.aniso_B[1][2]                            -1.098 
_refine.aniso_B[1][3]                            0.000 
_refine.aniso_B[2][2]                            -2.196 
_refine.aniso_B[2][3]                            0.000 
_refine.aniso_B[3][3]                            7.124 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               41.030 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               0.971 
_refine.correlation_coeff_Fo_to_Fc_free          0.951 
_refine.details                                  'Hydrogens have been added in their riding positions' 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9QA1 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.200 
_refine.ls_d_res_low                             43.170 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     58400 
_refine.ls_number_reflns_R_free                  2649 
_refine.ls_number_reflns_R_work                  55751 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.914 
_refine.ls_percent_reflns_R_free                 4.536 
_refine.ls_R_factor_all                          0.172 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       0.2115 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1699 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'MASK BULK SOLVENT' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.correlation_coeff_I_to_Fcsqd_work        ? 
_refine.correlation_coeff_I_to_Fcsqd_free        ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       0.148 
_refine.pdbx_overall_ESU_R_Free                  0.145 
_refine.pdbx_solvent_vdw_probe_radii             1.200 
_refine.pdbx_solvent_ion_probe_radii             0.800 
_refine.pdbx_solvent_shrinkage_radii             0.800 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             6.020 
_refine.overall_SU_ML                            0.135 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.200 
_refine_hist.d_res_low                        43.170 
_refine_hist.number_atoms_solvent             243 
_refine_hist.number_atoms_total               5253 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        4909 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         101 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.008  0.012  5153  ? r_bond_refined_d               ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.016  4666  ? r_bond_other_d                 ? ? 
'X-RAY DIFFRACTION' ? 1.729  1.829  6997  ? r_angle_refined_deg            ? ? 
'X-RAY DIFFRACTION' ? 0.606  1.774  10802 ? r_angle_other_deg              ? ? 
'X-RAY DIFFRACTION' ? 6.116  5.000  597   ? r_dihedral_angle_1_deg         ? ? 
'X-RAY DIFFRACTION' ? 8.956  5.000  24    ? r_dihedral_angle_2_deg         ? ? 
'X-RAY DIFFRACTION' ? 14.666 10.000 859   ? r_dihedral_angle_3_deg         ? ? 
'X-RAY DIFFRACTION' ? 14.770 10.000 262   ? r_dihedral_angle_6_deg         ? ? 
'X-RAY DIFFRACTION' ? 0.176  0.200  755   ? r_chiral_restr                 ? ? 
'X-RAY DIFFRACTION' ? 0.007  0.020  5990  ? r_gen_planes_refined           ? ? 
'X-RAY DIFFRACTION' ? 0.001  0.020  1198  ? r_gen_planes_other             ? ? 
'X-RAY DIFFRACTION' ? 0.222  0.200  1087  ? r_nbd_refined                  ? ? 
'X-RAY DIFFRACTION' ? 0.186  0.200  4227  ? r_symmetry_nbd_other           ? ? 
'X-RAY DIFFRACTION' ? 0.192  0.200  2584  ? r_nbtor_refined                ? ? 
'X-RAY DIFFRACTION' ? 0.080  0.200  2640  ? r_symmetry_nbtor_other         ? ? 
'X-RAY DIFFRACTION' ? 0.152  0.200  214   ? r_xyhbond_nbd_refined          ? ? 
'X-RAY DIFFRACTION' ? 0.026  0.200  1     ? r_symmetry_xyhbond_nbd_other   ? ? 
'X-RAY DIFFRACTION' ? 0.061  0.200  8     ? r_symmetry_nbd_refined         ? ? 
'X-RAY DIFFRACTION' ? 0.249  0.200  39    ? r_nbd_other                    ? ? 
'X-RAY DIFFRACTION' ? 0.163  0.200  9     ? r_symmetry_xyhbond_nbd_refined ? ? 
'X-RAY DIFFRACTION' ? 3.043  3.716  2397  ? r_mcbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 3.042  3.717  2398  ? r_mcbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 4.310  6.674  2991  ? r_mcangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 4.310  6.674  2992  ? r_mcangle_other                ? ? 
'X-RAY DIFFRACTION' ? 5.175  4.384  2756  ? r_scbond_it                    ? ? 
'X-RAY DIFFRACTION' ? 5.174  4.384  2757  ? r_scbond_other                 ? ? 
'X-RAY DIFFRACTION' ? 7.867  7.791  4006  ? r_scangle_it                   ? ? 
'X-RAY DIFFRACTION' ? 7.866  7.791  4007  ? r_scangle_other                ? ? 
'X-RAY DIFFRACTION' ? 8.676  37.888 5950  ? r_lrange_it                    ? ? 
'X-RAY DIFFRACTION' ? 8.680  37.669 5917  ? r_lrange_other                 ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.correlation_coeff_Fo_to_Fc 
_refine_ls_shell.correlation_coeff_Fo_to_Fc_free 
_refine_ls_shell.correlation_coeff_I_to_Fcsqd_work 
_refine_ls_shell.correlation_coeff_I_to_Fcsqd_free 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.200 2.257  4302 . 217 4071 99.6746  . 0.316 . . 0.314 . . . . . 0.321 . . . . . 20 . 0.892 0.875 0.357 
'X-RAY DIFFRACTION' 2.257 2.319  4186 . 205 3977 99.9044  . 0.296 . . 0.295 . . . . . 0.298 . . . . . 20 . 0.914 0.898 0.321 
'X-RAY DIFFRACTION' 2.319 2.386  4108 . 190 3915 99.9270  . 0.267 . . 0.267 . . . . . 0.267 . . . . . 20 . 0.936 0.929 0.271 
'X-RAY DIFFRACTION' 2.386 2.459  3985 . 183 3800 99.9498  . 0.257 . . 0.256 . . . . . 0.252 . . . . . 20 . 0.944 0.934 0.289 
'X-RAY DIFFRACTION' 2.459 2.539  3852 . 194 3656 99.9481  . 0.228 . . 0.226 . . . . . 0.216 . . . . . 20 . 0.961 0.942 0.273 
'X-RAY DIFFRACTION' 2.539 2.628  3705 . 184 3520 99.9730  . 0.220 . . 0.219 . . . . . 0.207 . . . . . 20 . 0.967 0.956 0.254 
'X-RAY DIFFRACTION' 2.628 2.727  3599 . 145 3453 99.9722  . 0.212 . . 0.211 . . . . . 0.197 . . . . . 20 . 0.971 0.958 0.254 
'X-RAY DIFFRACTION' 2.727 2.838  3461 . 162 3299 100.0000 . 0.199 . . 0.196 . . . . . 0.181 . . . . . 20 . 0.976 0.958 0.278 
'X-RAY DIFFRACTION' 2.838 2.963  3320 . 119 3201 100.0000 . 0.190 . . 0.188 . . . . . 0.174 . . . . . 20 . 0.977 0.962 0.240 
'X-RAY DIFFRACTION' 2.963 3.107  3190 . 182 3008 100.0000 . 0.180 . . 0.178 . . . . . 0.167 . . . . . 20 . 0.981 0.968 0.218 
'X-RAY DIFFRACTION' 3.107 3.274  2994 . 169 2825 100.0000 . 0.175 . . 0.173 . . . . . 0.164 . . . . . 20 . 0.983 0.974 0.208 
'X-RAY DIFFRACTION' 3.274 3.472  2857 . 113 2744 100.0000 . 0.172 . . 0.170 . . . . . 0.164 . . . . . 20 . 0.985 0.974 0.219 
'X-RAY DIFFRACTION' 3.472 3.710  2679 . 102 2577 100.0000 . 0.156 . . 0.155 . . . . . 0.151 . . . . . 20 . 0.988 0.983 0.182 
'X-RAY DIFFRACTION' 3.710 4.005  2493 . 138 2355 100.0000 . 0.140 . . 0.139 . . . . . 0.136 . . . . . 20 . 0.991 0.988 0.155 
'X-RAY DIFFRACTION' 4.005 4.383  2308 . 94  2214 100.0000 . 0.119 . . 0.118 . . . . . 0.116 . . . . . 20 . 0.992 0.984 0.164 
'X-RAY DIFFRACTION' 4.383 4.894  2081 . 53  2028 100.0000 . 0.109 . . 0.108 . . . . . 0.107 . . . . . 20 . 0.993 0.990 0.136 
'X-RAY DIFFRACTION' 4.894 5.639  1847 . 97  1750 100.0000 . 0.118 . . 0.116 . . . . . 0.116 . . . . . 20 . 0.993 0.987 0.152 
'X-RAY DIFFRACTION' 5.639 6.877  1552 . 56  1496 100.0000 . 0.141 . . 0.139 . . . . . 0.138 . . . . . 20 . 0.992 0.981 0.194 
'X-RAY DIFFRACTION' 6.877 9.605  1222 . 14  1208 100.0000 . 0.121 . . 0.120 . . . . . 0.123 . . . . . 20 . 0.993 0.990 0.183 
'X-RAY DIFFRACTION' 9.605 43.170 691  . 32  654  99.2764  . 0.144 . . 0.143 . . . . . 0.162 . . . . . 20 . 0.987 0.978 0.168 
# 
_struct.entry_id                     9QA1 
_struct.title                        
'Drosophila melanogaster angiotensin converting enzyme homologue, AnCE in complex with VW dipeptide' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9QA1 
_struct_keywords.text            'metalloprotease, dipeptides, hypertension, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 3 ? 
E N N 4 ? 
F N N 5 ? 
G N N 5 ? 
H N N 6 ? 
I N N 6 ? 
J N N 6 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP ACE_DROME Q10714 ? 1 
;VKEEIQAKEYLENLNKELAKRTNVETEAAWAYGSNITDENEKKKNEISAELAKFMKEVASDTTKFQWRSYQSEDLKRQFK
ALTKLGYAALPEDDYAELLDTLSAMESNFAKVKVCDYKDSTKCDLALDPEIEEVISKSRDHEELAYYWREFYDKAGTAVR
SQFERYVELNTKAAKLNNFTSGAEAWLDEYEDDTFEQQLEDIFADIRPLYQQIHGYVRFRLRKHYGDAVVSETGPIPMHL
LGNMWAQQWSEIADIVSPFPEKPLVDVSAEMEKQGYTPLKMFQMGDDFFTSMNLTKLPQDFWDKSIIEKPTDGRDLVCHA
SAWDFYLTDDVRIKQCTRVTQDQLFTVHHELGHIQYFLQYQHQPFVYRTGANPGFHEAVGDVLSLSVSTPKHLEKIGLLK
DYVRDDEARINQLFLTALDKIVFLPFAFTMDKYRWSLFRGEVDKANWNCAFWKLRDEYSGIEPPVVRSEKDFDAPAKYHI
SADVEYLRYLVSFIIQFQFYKSACIKAGQYDPDNVELPLDNCDIYGSAAAGAAFHNMLSMGASKPWPDALEAFNGERIMS
GKAIAEYFEPLRVWLEAENIKNNVHIGWTTSNKCVS
;
19 
2 PDB 9QA1      9QA1   ? 2 ? 1  
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9QA1 A 1 ? 596 ? Q10714 19   ? 614  ? 19   614  
2 2 9QA1 B 1 ? 2   ? 9QA1   1701 ? 1702 ? 1701 1702 
3 2 9QA1 D 1 ? 2   ? 9QA1   1629 ? 1630 ? 1629 1630 
# 
_struct_ref_seq_dif.align_id                     1 
_struct_ref_seq_dif.pdbx_pdb_id_code             9QA1 
_struct_ref_seq_dif.mon_id                       ILE 
_struct_ref_seq_dif.pdbx_pdb_strand_id           A 
_struct_ref_seq_dif.seq_num                      328 
_struct_ref_seq_dif.pdbx_pdb_ins_code            ? 
_struct_ref_seq_dif.pdbx_seq_db_name             UNP 
_struct_ref_seq_dif.pdbx_seq_db_accession_code   Q10714 
_struct_ref_seq_dif.db_mon_id                    THR 
_struct_ref_seq_dif.pdbx_seq_db_seq_num          346 
_struct_ref_seq_dif.details                      conflict 
_struct_ref_seq_dif.pdbx_auth_seq_num            346 
_struct_ref_seq_dif.pdbx_ordinal                 1 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   trimeric 
_pdbx_struct_assembly.oligomeric_count     3 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 2830  ? 
1 MORE         -24   ? 
1 'SSA (A^2)'  24840 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 VAL A 1   ? SER A 34  ? VAL A 19  SER A 52  1 ? 34 
HELX_P HELX_P2  AA2 THR A 37  ? THR A 63  ? THR A 55  THR A 81  1 ? 27 
HELX_P HELX_P3  AA3 LYS A 64  ? PHE A 65  ? LYS A 82  PHE A 83  5 ? 2  
HELX_P HELX_P4  AA4 GLN A 66  ? TYR A 70  ? GLN A 84  TYR A 88  5 ? 5  
HELX_P HELX_P5  AA5 SER A 72  ? LYS A 84  ? SER A 90  LYS A 102 1 ? 13 
HELX_P HELX_P6  AA6 LEU A 85  ? LEU A 90  ? LEU A 103 LEU A 108 5 ? 6  
HELX_P HELX_P7  AA7 PRO A 91  ? LYS A 111 ? PRO A 109 LYS A 129 1 ? 21 
HELX_P HELX_P8  AA8 PRO A 129 ? SER A 138 ? PRO A 147 SER A 156 1 ? 10 
HELX_P HELX_P9  AA9 ASP A 140 ? GLY A 156 ? ASP A 158 GLY A 174 1 ? 17 
HELX_P HELX_P10 AB1 VAL A 159 ? ASN A 177 ? VAL A 177 ASN A 195 1 ? 19 
HELX_P HELX_P11 AB2 SER A 181 ? GLU A 189 ? SER A 199 GLU A 207 1 ? 9  
HELX_P HELX_P12 AB3 THR A 194 ? GLY A 226 ? THR A 212 GLY A 244 1 ? 33 
HELX_P HELX_P13 AB4 HIS A 239 ? LEU A 241 ? HIS A 257 LEU A 259 5 ? 3  
HELX_P HELX_P14 AB5 TRP A 249 ? GLU A 251 ? TRP A 267 GLU A 269 5 ? 3  
HELX_P HELX_P15 AB6 ILE A 252 ? SER A 257 ? ILE A 270 SER A 275 1 ? 6  
HELX_P HELX_P16 AB7 VAL A 267 ? GLN A 274 ? VAL A 285 GLN A 292 1 ? 8  
HELX_P HELX_P17 AB8 THR A 277 ? MET A 292 ? THR A 295 MET A 310 1 ? 16 
HELX_P HELX_P18 AB9 PRO A 298 ? SER A 305 ? PRO A 316 SER A 323 1 ? 8  
HELX_P HELX_P19 AC1 THR A 340 ? TYR A 360 ? THR A 358 TYR A 378 1 ? 21 
HELX_P HELX_P20 AC2 PRO A 364 ? ARG A 368 ? PRO A 382 ARG A 386 5 ? 5  
HELX_P HELX_P21 AC3 ASN A 372 ? SER A 388 ? ASN A 390 SER A 406 1 ? 17 
HELX_P HELX_P22 AC4 THR A 389 ? ILE A 396 ? THR A 407 ILE A 414 1 ? 8  
HELX_P HELX_P23 AC5 ASP A 405 ? ILE A 421 ? ASP A 423 ILE A 439 1 ? 17 
HELX_P HELX_P24 AC6 VAL A 422 ? ARG A 439 ? VAL A 440 ARG A 457 1 ? 18 
HELX_P HELX_P25 AC7 ASP A 443 ? ALA A 445 ? ASP A 461 ALA A 463 5 ? 3  
HELX_P HELX_P26 AC8 ASN A 446 ? GLY A 460 ? ASN A 464 GLY A 478 1 ? 15 
HELX_P HELX_P27 AC9 ASP A 473 ? ALA A 476 ? ASP A 491 ALA A 494 5 ? 4  
HELX_P HELX_P28 AD1 LYS A 477 ? ALA A 482 ? LYS A 495 ALA A 500 1 ? 6  
HELX_P HELX_P29 AD2 TYR A 486 ? ALA A 507 ? TYR A 504 ALA A 525 1 ? 22 
HELX_P HELX_P30 AD3 PRO A 518 ? CYS A 522 ? PRO A 536 CYS A 540 5 ? 5  
HELX_P HELX_P31 AD4 SER A 527 ? SER A 539 ? SER A 545 SER A 557 1 ? 13 
HELX_P HELX_P32 AD5 PRO A 545 ? GLY A 555 ? PRO A 563 GLY A 573 1 ? 11 
HELX_P HELX_P33 AD6 GLY A 561 ? ASN A 582 ? GLY A 579 ASN A 600 1 ? 22 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ?    ? A CYS 115 SG  ? ? ? 1_555 A CYS 123 SG ? ? A CYS 133 A CYS 141  1_555 ? ? ? ? ? ? ? 2.170 ? ?               
disulf2 disulf ?    ? A CYS 318 SG  ? ? ? 1_555 A CYS 336 SG ? ? A CYS 336 A CYS 354  1_555 ? ? ? ? ? ? ? 2.100 ? ?               
disulf3 disulf ?    ? A CYS 449 SG  ? ? ? 1_555 A CYS 594 SG ? ? A CYS 467 A CYS 612  1_555 ? ? ? ? ? ? ? 2.173 ? ?               
disulf4 disulf ?    ? A CYS 504 SG  ? ? ? 1_555 A CYS 522 SG ? ? A CYS 522 A CYS 540  1_555 ? ? ? ? ? ? ? 2.034 ? ?               
covale1 covale one  ? A ASN 35  ND2 ? ? ? 1_555 G NAG .   C1 ? ? A ASN 53  A NAG 703  1_555 ? ? ? ? ? ? ? 1.434 ? N-Glycosylation 
covale2 covale one  ? A ASN 178 ND2 ? ? ? 1_555 D NAG .   C1 ? ? A ASN 196 C NAG 1    1_555 ? ? ? ? ? ? ? 1.433 ? N-Glycosylation 
covale3 covale one  ? A ASN 293 ND2 ? ? ? 1_555 F NAG .   C1 ? ? A ASN 311 A NAG 702  1_555 ? ? ? ? ? ? ? 1.439 ? N-Glycosylation 
covale4 covale both ? D NAG .   O4  ? ? ? 1_555 D NAG .   C1 ? ? C NAG 1   C NAG 2    1_555 ? ? ? ? ? ? ? 1.399 ? ?               
covale5 covale both ? D NAG .   O4  ? ? ? 1_555 D BMA .   C1 ? ? C NAG 2   C BMA 3    1_555 ? ? ? ? ? ? ? 1.394 ? ?               
covale6 covale both ? D BMA .   O3  ? ? ? 1_555 D MAN .   C1 ? ? C BMA 3   C MAN 4    1_555 ? ? ? ? ? ? ? 1.391 ? ?               
covale7 covale both ? D BMA .   O6  ? ? ? 1_555 D MAN .   C1 ? ? C BMA 3   C MAN 6    1_555 ? ? ? ? ? ? ? 1.398 ? ?               
covale8 covale both ? D MAN .   O6  ? ? ? 1_555 D BMA .   C1 ? ? C MAN 4   C BMA 5    1_555 ? ? ? ? ? ? ? 1.407 ? ?               
metalc1 metalc ?    ? A HIS 349 NE2 ? ? ? 1_555 E ZN  .   ZN ? ? A HIS 367 A ZN  701  1_555 ? ? ? ? ? ? ? 2.103 ? ?               
metalc2 metalc ?    ? A HIS 353 NE2 ? ? ? 1_555 E ZN  .   ZN ? ? A HIS 371 A ZN  701  1_555 ? ? ? ? ? ? ? 2.142 ? ?               
metalc3 metalc ?    ? A GLU 377 OE1 ? ? ? 1_555 E ZN  .   ZN ? ? A GLU 395 A ZN  701  1_555 ? ? ? ? ? ? ? 1.931 ? ?               
metalc4 metalc ?    ? E ZN  .   ZN  ? ? ? 1_555 I HOH .   O  ? ? A ZN  701 B HOH 1801 1_555 ? ? ? ? ? ? ? 2.011 ? ?               
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
covale ? ? 
metalc ? ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1 NE2 ? A HIS 349 ? A HIS 367 ? 1_555 ZN ? E ZN . ? A ZN 701 ? 1_555 NE2 ? A HIS 353 ? A HIS 371  ? 1_555 107.0 ? 
2 NE2 ? A HIS 349 ? A HIS 367 ? 1_555 ZN ? E ZN . ? A ZN 701 ? 1_555 OE1 ? A GLU 377 ? A GLU 395  ? 1_555 88.9  ? 
3 NE2 ? A HIS 353 ? A HIS 371 ? 1_555 ZN ? E ZN . ? A ZN 701 ? 1_555 OE1 ? A GLU 377 ? A GLU 395  ? 1_555 98.2  ? 
4 NE2 ? A HIS 349 ? A HIS 367 ? 1_555 ZN ? E ZN . ? A ZN 701 ? 1_555 O   ? I HOH .   ? B HOH 1801 ? 1_555 116.4 ? 
5 NE2 ? A HIS 353 ? A HIS 371 ? 1_555 ZN ? E ZN . ? A ZN 701 ? 1_555 O   ? I HOH .   ? B HOH 1801 ? 1_555 118.3 ? 
6 OE1 ? A GLU 377 ? A GLU 395 ? 1_555 ZN ? E ZN . ? A ZN 701 ? 1_555 O   ? I HOH .   ? B HOH 1801 ? 1_555 123.1 ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 NAG D .   ? ASN A 178 ? NAG C 1   ? 1_555 ASN A 196 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
2 NAG F .   ? ASN A 293 ? NAG A 702 ? 1_555 ASN A 311 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
3 NAG G .   ? ASN A 35  ? NAG A 703 ? 1_555 ASN A 53  ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
4 CYS A 115 ? CYS A 123 ? CYS A 133 ? 1_555 CYS A 141 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
5 CYS A 318 ? CYS A 336 ? CYS A 336 ? 1_555 CYS A 354 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
6 CYS A 449 ? CYS A 594 ? CYS A 467 ? 1_555 CYS A 612 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
7 CYS A 504 ? CYS A 522 ? CYS A 522 ? 1_555 CYS A 540 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          ASP 
_struct_mon_prot_cis.label_seq_id           128 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           ASP 
_struct_mon_prot_cis.auth_seq_id            146 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    129 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     147 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       5.47 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 2 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA2 1 2 ? parallel      
AA3 1 2 ? anti-parallel 
AA4 1 2 ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 LYS A 113 ? VAL A 114 ? LYS A 131 VAL A 132 
AA1 2 LEU A 125 ? ALA A 126 ? LEU A 143 ALA A 144 
AA2 1 ILE A 236 ? PRO A 237 ? ILE A 254 PRO A 255 
AA2 2 ILE A 461 ? GLU A 462 ? ILE A 479 GLU A 480 
AA3 1 SER A 321 ? ASP A 324 ? SER A 339 ASP A 342 
AA3 2 VAL A 331 ? LYS A 334 ? VAL A 349 LYS A 352 
AA4 1 ARG A 467 ? SER A 468 ? ARG A 485 SER A 486 
AA4 2 CYS A 594 ? VAL A 595 ? CYS A 612 VAL A 613 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N VAL A 114 ? N VAL A 132 O LEU A 125 ? O LEU A 143 
AA2 1 2 N ILE A 236 ? N ILE A 254 O GLU A 462 ? O GLU A 480 
AA3 1 2 N TRP A 323 ? N TRP A 341 O ARG A 332 ? O ARG A 350 
AA4 1 2 N ARG A 467 ? N ARG A 485 O VAL A 595 ? O VAL A 613 
# 
_pdbx_entry_details.entry_id                   9QA1 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   O 
_pdbx_validate_close_contact.auth_asym_id_1   A 
_pdbx_validate_close_contact.auth_comp_id_1   HOH 
_pdbx_validate_close_contact.auth_seq_id_1    1000 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   O 
_pdbx_validate_close_contact.auth_asym_id_2   A 
_pdbx_validate_close_contact.auth_comp_id_2   HOH 
_pdbx_validate_close_contact.auth_seq_id_2    1005 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             2.05 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1 1 NE A ARG 157 ? ? CZ A ARG 157 ? ? NH1 A ARG 157 ? ? 124.93 120.30 4.63   0.50 N 
2 1 NE A ARG 157 ? ? CZ A ARG 157 ? ? NH2 A ARG 157 ? ? 117.06 120.30 -3.24  0.50 N 
3 1 CG A ARG 178 ? ? CD A ARG 178 ? ? NE  A ARG 178 ? ? 97.35  111.80 -14.45 2.10 N 
4 1 NE A ARG 473 ? ? CZ A ARG 473 ? ? NH2 A ARG 473 ? ? 116.61 120.30 -3.69  0.50 N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASN A 53  ? ? -175.53 85.16   
2 1 PRO A 109 ? ? -48.72  150.01  
3 1 ASP A 137 ? ? -171.30 95.88   
4 1 ASP A 210 ? ? -166.34 117.59  
5 1 LEU A 345 ? ? -108.33 -132.77 
6 1 ASP A 531 ? ? -94.71  39.44   
7 1 ASN A 572 ? ? -151.07 9.17    
# 
loop_
_pdbx_validate_planes.id 
_pdbx_validate_planes.PDB_model_num 
_pdbx_validate_planes.auth_comp_id 
_pdbx_validate_planes.auth_asym_id 
_pdbx_validate_planes.auth_seq_id 
_pdbx_validate_planes.PDB_ins_code 
_pdbx_validate_planes.label_alt_id 
_pdbx_validate_planes.rmsd 
_pdbx_validate_planes.type 
1 1 ARG A 332 ? ? 0.108 'SIDE CHAIN' 
2 1 ARG A 350 ? ? 0.081 'SIDE CHAIN' 
3 1 ARG A 356 ? ? 0.080 'SIDE CHAIN' 
4 1 ARG A 473 ? ? 0.089 'SIDE CHAIN' 
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      A 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       1037 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   6.35 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
BMA C1   C  N R 74  
BMA C2   C  N S 75  
BMA C3   C  N S 76  
BMA C4   C  N S 77  
BMA C5   C  N R 78  
BMA C6   C  N N 79  
BMA O1   O  N N 80  
BMA O2   O  N N 81  
BMA O3   O  N N 82  
BMA O4   O  N N 83  
BMA O5   O  N N 84  
BMA O6   O  N N 85  
BMA H1   H  N N 86  
BMA H2   H  N N 87  
BMA H3   H  N N 88  
BMA H4   H  N N 89  
BMA H5   H  N N 90  
BMA H61  H  N N 91  
BMA H62  H  N N 92  
BMA HO1  H  N N 93  
BMA HO2  H  N N 94  
BMA HO3  H  N N 95  
BMA HO4  H  N N 96  
BMA HO6  H  N N 97  
CYS N    N  N N 98  
CYS CA   C  N R 99  
CYS C    C  N N 100 
CYS O    O  N N 101 
CYS CB   C  N N 102 
CYS SG   S  N N 103 
CYS OXT  O  N N 104 
CYS H    H  N N 105 
CYS H2   H  N N 106 
CYS HA   H  N N 107 
CYS HB2  H  N N 108 
CYS HB3  H  N N 109 
CYS HG   H  N N 110 
CYS HXT  H  N N 111 
GLN N    N  N N 112 
GLN CA   C  N S 113 
GLN C    C  N N 114 
GLN O    O  N N 115 
GLN CB   C  N N 116 
GLN CG   C  N N 117 
GLN CD   C  N N 118 
GLN OE1  O  N N 119 
GLN NE2  N  N N 120 
GLN OXT  O  N N 121 
GLN H    H  N N 122 
GLN H2   H  N N 123 
GLN HA   H  N N 124 
GLN HB2  H  N N 125 
GLN HB3  H  N N 126 
GLN HG2  H  N N 127 
GLN HG3  H  N N 128 
GLN HE21 H  N N 129 
GLN HE22 H  N N 130 
GLN HXT  H  N N 131 
GLU N    N  N N 132 
GLU CA   C  N S 133 
GLU C    C  N N 134 
GLU O    O  N N 135 
GLU CB   C  N N 136 
GLU CG   C  N N 137 
GLU CD   C  N N 138 
GLU OE1  O  N N 139 
GLU OE2  O  N N 140 
GLU OXT  O  N N 141 
GLU H    H  N N 142 
GLU H2   H  N N 143 
GLU HA   H  N N 144 
GLU HB2  H  N N 145 
GLU HB3  H  N N 146 
GLU HG2  H  N N 147 
GLU HG3  H  N N 148 
GLU HE2  H  N N 149 
GLU HXT  H  N N 150 
GLY N    N  N N 151 
GLY CA   C  N N 152 
GLY C    C  N N 153 
GLY O    O  N N 154 
GLY OXT  O  N N 155 
GLY H    H  N N 156 
GLY H2   H  N N 157 
GLY HA2  H  N N 158 
GLY HA3  H  N N 159 
GLY HXT  H  N N 160 
HIS N    N  N N 161 
HIS CA   C  N S 162 
HIS C    C  N N 163 
HIS O    O  N N 164 
HIS CB   C  N N 165 
HIS CG   C  Y N 166 
HIS ND1  N  Y N 167 
HIS CD2  C  Y N 168 
HIS CE1  C  Y N 169 
HIS NE2  N  Y N 170 
HIS OXT  O  N N 171 
HIS H    H  N N 172 
HIS H2   H  N N 173 
HIS HA   H  N N 174 
HIS HB2  H  N N 175 
HIS HB3  H  N N 176 
HIS HD1  H  N N 177 
HIS HD2  H  N N 178 
HIS HE1  H  N N 179 
HIS HE2  H  N N 180 
HIS HXT  H  N N 181 
HOH O    O  N N 182 
HOH H1   H  N N 183 
HOH H2   H  N N 184 
ILE N    N  N N 185 
ILE CA   C  N S 186 
ILE C    C  N N 187 
ILE O    O  N N 188 
ILE CB   C  N S 189 
ILE CG1  C  N N 190 
ILE CG2  C  N N 191 
ILE CD1  C  N N 192 
ILE OXT  O  N N 193 
ILE H    H  N N 194 
ILE H2   H  N N 195 
ILE HA   H  N N 196 
ILE HB   H  N N 197 
ILE HG12 H  N N 198 
ILE HG13 H  N N 199 
ILE HG21 H  N N 200 
ILE HG22 H  N N 201 
ILE HG23 H  N N 202 
ILE HD11 H  N N 203 
ILE HD12 H  N N 204 
ILE HD13 H  N N 205 
ILE HXT  H  N N 206 
LEU N    N  N N 207 
LEU CA   C  N S 208 
LEU C    C  N N 209 
LEU O    O  N N 210 
LEU CB   C  N N 211 
LEU CG   C  N N 212 
LEU CD1  C  N N 213 
LEU CD2  C  N N 214 
LEU OXT  O  N N 215 
LEU H    H  N N 216 
LEU H2   H  N N 217 
LEU HA   H  N N 218 
LEU HB2  H  N N 219 
LEU HB3  H  N N 220 
LEU HG   H  N N 221 
LEU HD11 H  N N 222 
LEU HD12 H  N N 223 
LEU HD13 H  N N 224 
LEU HD21 H  N N 225 
LEU HD22 H  N N 226 
LEU HD23 H  N N 227 
LEU HXT  H  N N 228 
LYS N    N  N N 229 
LYS CA   C  N S 230 
LYS C    C  N N 231 
LYS O    O  N N 232 
LYS CB   C  N N 233 
LYS CG   C  N N 234 
LYS CD   C  N N 235 
LYS CE   C  N N 236 
LYS NZ   N  N N 237 
LYS OXT  O  N N 238 
LYS H    H  N N 239 
LYS H2   H  N N 240 
LYS HA   H  N N 241 
LYS HB2  H  N N 242 
LYS HB3  H  N N 243 
LYS HG2  H  N N 244 
LYS HG3  H  N N 245 
LYS HD2  H  N N 246 
LYS HD3  H  N N 247 
LYS HE2  H  N N 248 
LYS HE3  H  N N 249 
LYS HZ1  H  N N 250 
LYS HZ2  H  N N 251 
LYS HZ3  H  N N 252 
LYS HXT  H  N N 253 
MAN C1   C  N S 254 
MAN C2   C  N S 255 
MAN C3   C  N S 256 
MAN C4   C  N S 257 
MAN C5   C  N R 258 
MAN C6   C  N N 259 
MAN O1   O  N N 260 
MAN O2   O  N N 261 
MAN O3   O  N N 262 
MAN O4   O  N N 263 
MAN O5   O  N N 264 
MAN O6   O  N N 265 
MAN H1   H  N N 266 
MAN H2   H  N N 267 
MAN H3   H  N N 268 
MAN H4   H  N N 269 
MAN H5   H  N N 270 
MAN H61  H  N N 271 
MAN H62  H  N N 272 
MAN HO1  H  N N 273 
MAN HO2  H  N N 274 
MAN HO3  H  N N 275 
MAN HO4  H  N N 276 
MAN HO6  H  N N 277 
MET N    N  N N 278 
MET CA   C  N S 279 
MET C    C  N N 280 
MET O    O  N N 281 
MET CB   C  N N 282 
MET CG   C  N N 283 
MET SD   S  N N 284 
MET CE   C  N N 285 
MET OXT  O  N N 286 
MET H    H  N N 287 
MET H2   H  N N 288 
MET HA   H  N N 289 
MET HB2  H  N N 290 
MET HB3  H  N N 291 
MET HG2  H  N N 292 
MET HG3  H  N N 293 
MET HE1  H  N N 294 
MET HE2  H  N N 295 
MET HE3  H  N N 296 
MET HXT  H  N N 297 
NAG C1   C  N R 298 
NAG C2   C  N R 299 
NAG C3   C  N R 300 
NAG C4   C  N S 301 
NAG C5   C  N R 302 
NAG C6   C  N N 303 
NAG C7   C  N N 304 
NAG C8   C  N N 305 
NAG N2   N  N N 306 
NAG O1   O  N N 307 
NAG O3   O  N N 308 
NAG O4   O  N N 309 
NAG O5   O  N N 310 
NAG O6   O  N N 311 
NAG O7   O  N N 312 
NAG H1   H  N N 313 
NAG H2   H  N N 314 
NAG H3   H  N N 315 
NAG H4   H  N N 316 
NAG H5   H  N N 317 
NAG H61  H  N N 318 
NAG H62  H  N N 319 
NAG H81  H  N N 320 
NAG H82  H  N N 321 
NAG H83  H  N N 322 
NAG HN2  H  N N 323 
NAG HO1  H  N N 324 
NAG HO3  H  N N 325 
NAG HO4  H  N N 326 
NAG HO6  H  N N 327 
PHE N    N  N N 328 
PHE CA   C  N S 329 
PHE C    C  N N 330 
PHE O    O  N N 331 
PHE CB   C  N N 332 
PHE CG   C  Y N 333 
PHE CD1  C  Y N 334 
PHE CD2  C  Y N 335 
PHE CE1  C  Y N 336 
PHE CE2  C  Y N 337 
PHE CZ   C  Y N 338 
PHE OXT  O  N N 339 
PHE H    H  N N 340 
PHE H2   H  N N 341 
PHE HA   H  N N 342 
PHE HB2  H  N N 343 
PHE HB3  H  N N 344 
PHE HD1  H  N N 345 
PHE HD2  H  N N 346 
PHE HE1  H  N N 347 
PHE HE2  H  N N 348 
PHE HZ   H  N N 349 
PHE HXT  H  N N 350 
PRO N    N  N N 351 
PRO CA   C  N S 352 
PRO C    C  N N 353 
PRO O    O  N N 354 
PRO CB   C  N N 355 
PRO CG   C  N N 356 
PRO CD   C  N N 357 
PRO OXT  O  N N 358 
PRO H    H  N N 359 
PRO HA   H  N N 360 
PRO HB2  H  N N 361 
PRO HB3  H  N N 362 
PRO HG2  H  N N 363 
PRO HG3  H  N N 364 
PRO HD2  H  N N 365 
PRO HD3  H  N N 366 
PRO HXT  H  N N 367 
SER N    N  N N 368 
SER CA   C  N S 369 
SER C    C  N N 370 
SER O    O  N N 371 
SER CB   C  N N 372 
SER OG   O  N N 373 
SER OXT  O  N N 374 
SER H    H  N N 375 
SER H2   H  N N 376 
SER HA   H  N N 377 
SER HB2  H  N N 378 
SER HB3  H  N N 379 
SER HG   H  N N 380 
SER HXT  H  N N 381 
THR N    N  N N 382 
THR CA   C  N S 383 
THR C    C  N N 384 
THR O    O  N N 385 
THR CB   C  N R 386 
THR OG1  O  N N 387 
THR CG2  C  N N 388 
THR OXT  O  N N 389 
THR H    H  N N 390 
THR H2   H  N N 391 
THR HA   H  N N 392 
THR HB   H  N N 393 
THR HG1  H  N N 394 
THR HG21 H  N N 395 
THR HG22 H  N N 396 
THR HG23 H  N N 397 
THR HXT  H  N N 398 
TRP N    N  N N 399 
TRP CA   C  N S 400 
TRP C    C  N N 401 
TRP O    O  N N 402 
TRP CB   C  N N 403 
TRP CG   C  Y N 404 
TRP CD1  C  Y N 405 
TRP CD2  C  Y N 406 
TRP NE1  N  Y N 407 
TRP CE2  C  Y N 408 
TRP CE3  C  Y N 409 
TRP CZ2  C  Y N 410 
TRP CZ3  C  Y N 411 
TRP CH2  C  Y N 412 
TRP OXT  O  N N 413 
TRP H    H  N N 414 
TRP H2   H  N N 415 
TRP HA   H  N N 416 
TRP HB2  H  N N 417 
TRP HB3  H  N N 418 
TRP HD1  H  N N 419 
TRP HE1  H  N N 420 
TRP HE3  H  N N 421 
TRP HZ2  H  N N 422 
TRP HZ3  H  N N 423 
TRP HH2  H  N N 424 
TRP HXT  H  N N 425 
TYR N    N  N N 426 
TYR CA   C  N S 427 
TYR C    C  N N 428 
TYR O    O  N N 429 
TYR CB   C  N N 430 
TYR CG   C  Y N 431 
TYR CD1  C  Y N 432 
TYR CD2  C  Y N 433 
TYR CE1  C  Y N 434 
TYR CE2  C  Y N 435 
TYR CZ   C  Y N 436 
TYR OH   O  N N 437 
TYR OXT  O  N N 438 
TYR H    H  N N 439 
TYR H2   H  N N 440 
TYR HA   H  N N 441 
TYR HB2  H  N N 442 
TYR HB3  H  N N 443 
TYR HD1  H  N N 444 
TYR HD2  H  N N 445 
TYR HE1  H  N N 446 
TYR HE2  H  N N 447 
TYR HH   H  N N 448 
TYR HXT  H  N N 449 
VAL N    N  N N 450 
VAL CA   C  N S 451 
VAL C    C  N N 452 
VAL O    O  N N 453 
VAL CB   C  N N 454 
VAL CG1  C  N N 455 
VAL CG2  C  N N 456 
VAL OXT  O  N N 457 
VAL H    H  N N 458 
VAL H2   H  N N 459 
VAL HA   H  N N 460 
VAL HB   H  N N 461 
VAL HG11 H  N N 462 
VAL HG12 H  N N 463 
VAL HG13 H  N N 464 
VAL HG21 H  N N 465 
VAL HG22 H  N N 466 
VAL HG23 H  N N 467 
VAL HXT  H  N N 468 
ZN  ZN   ZN N N 469 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
BMA C1  C2   sing N N 70  
BMA C1  O1   sing N N 71  
BMA C1  O5   sing N N 72  
BMA C1  H1   sing N N 73  
BMA C2  C3   sing N N 74  
BMA C2  O2   sing N N 75  
BMA C2  H2   sing N N 76  
BMA C3  C4   sing N N 77  
BMA C3  O3   sing N N 78  
BMA C3  H3   sing N N 79  
BMA C4  C5   sing N N 80  
BMA C4  O4   sing N N 81  
BMA C4  H4   sing N N 82  
BMA C5  C6   sing N N 83  
BMA C5  O5   sing N N 84  
BMA C5  H5   sing N N 85  
BMA C6  O6   sing N N 86  
BMA C6  H61  sing N N 87  
BMA C6  H62  sing N N 88  
BMA O1  HO1  sing N N 89  
BMA O2  HO2  sing N N 90  
BMA O3  HO3  sing N N 91  
BMA O4  HO4  sing N N 92  
BMA O6  HO6  sing N N 93  
CYS N   CA   sing N N 94  
CYS N   H    sing N N 95  
CYS N   H2   sing N N 96  
CYS CA  C    sing N N 97  
CYS CA  CB   sing N N 98  
CYS CA  HA   sing N N 99  
CYS C   O    doub N N 100 
CYS C   OXT  sing N N 101 
CYS CB  SG   sing N N 102 
CYS CB  HB2  sing N N 103 
CYS CB  HB3  sing N N 104 
CYS SG  HG   sing N N 105 
CYS OXT HXT  sing N N 106 
GLN N   CA   sing N N 107 
GLN N   H    sing N N 108 
GLN N   H2   sing N N 109 
GLN CA  C    sing N N 110 
GLN CA  CB   sing N N 111 
GLN CA  HA   sing N N 112 
GLN C   O    doub N N 113 
GLN C   OXT  sing N N 114 
GLN CB  CG   sing N N 115 
GLN CB  HB2  sing N N 116 
GLN CB  HB3  sing N N 117 
GLN CG  CD   sing N N 118 
GLN CG  HG2  sing N N 119 
GLN CG  HG3  sing N N 120 
GLN CD  OE1  doub N N 121 
GLN CD  NE2  sing N N 122 
GLN NE2 HE21 sing N N 123 
GLN NE2 HE22 sing N N 124 
GLN OXT HXT  sing N N 125 
GLU N   CA   sing N N 126 
GLU N   H    sing N N 127 
GLU N   H2   sing N N 128 
GLU CA  C    sing N N 129 
GLU CA  CB   sing N N 130 
GLU CA  HA   sing N N 131 
GLU C   O    doub N N 132 
GLU C   OXT  sing N N 133 
GLU CB  CG   sing N N 134 
GLU CB  HB2  sing N N 135 
GLU CB  HB3  sing N N 136 
GLU CG  CD   sing N N 137 
GLU CG  HG2  sing N N 138 
GLU CG  HG3  sing N N 139 
GLU CD  OE1  doub N N 140 
GLU CD  OE2  sing N N 141 
GLU OE2 HE2  sing N N 142 
GLU OXT HXT  sing N N 143 
GLY N   CA   sing N N 144 
GLY N   H    sing N N 145 
GLY N   H2   sing N N 146 
GLY CA  C    sing N N 147 
GLY CA  HA2  sing N N 148 
GLY CA  HA3  sing N N 149 
GLY C   O    doub N N 150 
GLY C   OXT  sing N N 151 
GLY OXT HXT  sing N N 152 
HIS N   CA   sing N N 153 
HIS N   H    sing N N 154 
HIS N   H2   sing N N 155 
HIS CA  C    sing N N 156 
HIS CA  CB   sing N N 157 
HIS CA  HA   sing N N 158 
HIS C   O    doub N N 159 
HIS C   OXT  sing N N 160 
HIS CB  CG   sing N N 161 
HIS CB  HB2  sing N N 162 
HIS CB  HB3  sing N N 163 
HIS CG  ND1  sing Y N 164 
HIS CG  CD2  doub Y N 165 
HIS ND1 CE1  doub Y N 166 
HIS ND1 HD1  sing N N 167 
HIS CD2 NE2  sing Y N 168 
HIS CD2 HD2  sing N N 169 
HIS CE1 NE2  sing Y N 170 
HIS CE1 HE1  sing N N 171 
HIS NE2 HE2  sing N N 172 
HIS OXT HXT  sing N N 173 
HOH O   H1   sing N N 174 
HOH O   H2   sing N N 175 
ILE N   CA   sing N N 176 
ILE N   H    sing N N 177 
ILE N   H2   sing N N 178 
ILE CA  C    sing N N 179 
ILE CA  CB   sing N N 180 
ILE CA  HA   sing N N 181 
ILE C   O    doub N N 182 
ILE C   OXT  sing N N 183 
ILE CB  CG1  sing N N 184 
ILE CB  CG2  sing N N 185 
ILE CB  HB   sing N N 186 
ILE CG1 CD1  sing N N 187 
ILE CG1 HG12 sing N N 188 
ILE CG1 HG13 sing N N 189 
ILE CG2 HG21 sing N N 190 
ILE CG2 HG22 sing N N 191 
ILE CG2 HG23 sing N N 192 
ILE CD1 HD11 sing N N 193 
ILE CD1 HD12 sing N N 194 
ILE CD1 HD13 sing N N 195 
ILE OXT HXT  sing N N 196 
LEU N   CA   sing N N 197 
LEU N   H    sing N N 198 
LEU N   H2   sing N N 199 
LEU CA  C    sing N N 200 
LEU CA  CB   sing N N 201 
LEU CA  HA   sing N N 202 
LEU C   O    doub N N 203 
LEU C   OXT  sing N N 204 
LEU CB  CG   sing N N 205 
LEU CB  HB2  sing N N 206 
LEU CB  HB3  sing N N 207 
LEU CG  CD1  sing N N 208 
LEU CG  CD2  sing N N 209 
LEU CG  HG   sing N N 210 
LEU CD1 HD11 sing N N 211 
LEU CD1 HD12 sing N N 212 
LEU CD1 HD13 sing N N 213 
LEU CD2 HD21 sing N N 214 
LEU CD2 HD22 sing N N 215 
LEU CD2 HD23 sing N N 216 
LEU OXT HXT  sing N N 217 
LYS N   CA   sing N N 218 
LYS N   H    sing N N 219 
LYS N   H2   sing N N 220 
LYS CA  C    sing N N 221 
LYS CA  CB   sing N N 222 
LYS CA  HA   sing N N 223 
LYS C   O    doub N N 224 
LYS C   OXT  sing N N 225 
LYS CB  CG   sing N N 226 
LYS CB  HB2  sing N N 227 
LYS CB  HB3  sing N N 228 
LYS CG  CD   sing N N 229 
LYS CG  HG2  sing N N 230 
LYS CG  HG3  sing N N 231 
LYS CD  CE   sing N N 232 
LYS CD  HD2  sing N N 233 
LYS CD  HD3  sing N N 234 
LYS CE  NZ   sing N N 235 
LYS CE  HE2  sing N N 236 
LYS CE  HE3  sing N N 237 
LYS NZ  HZ1  sing N N 238 
LYS NZ  HZ2  sing N N 239 
LYS NZ  HZ3  sing N N 240 
LYS OXT HXT  sing N N 241 
MAN C1  C2   sing N N 242 
MAN C1  O1   sing N N 243 
MAN C1  O5   sing N N 244 
MAN C1  H1   sing N N 245 
MAN C2  C3   sing N N 246 
MAN C2  O2   sing N N 247 
MAN C2  H2   sing N N 248 
MAN C3  C4   sing N N 249 
MAN C3  O3   sing N N 250 
MAN C3  H3   sing N N 251 
MAN C4  C5   sing N N 252 
MAN C4  O4   sing N N 253 
MAN C4  H4   sing N N 254 
MAN C5  C6   sing N N 255 
MAN C5  O5   sing N N 256 
MAN C5  H5   sing N N 257 
MAN C6  O6   sing N N 258 
MAN C6  H61  sing N N 259 
MAN C6  H62  sing N N 260 
MAN O1  HO1  sing N N 261 
MAN O2  HO2  sing N N 262 
MAN O3  HO3  sing N N 263 
MAN O4  HO4  sing N N 264 
MAN O6  HO6  sing N N 265 
MET N   CA   sing N N 266 
MET N   H    sing N N 267 
MET N   H2   sing N N 268 
MET CA  C    sing N N 269 
MET CA  CB   sing N N 270 
MET CA  HA   sing N N 271 
MET C   O    doub N N 272 
MET C   OXT  sing N N 273 
MET CB  CG   sing N N 274 
MET CB  HB2  sing N N 275 
MET CB  HB3  sing N N 276 
MET CG  SD   sing N N 277 
MET CG  HG2  sing N N 278 
MET CG  HG3  sing N N 279 
MET SD  CE   sing N N 280 
MET CE  HE1  sing N N 281 
MET CE  HE2  sing N N 282 
MET CE  HE3  sing N N 283 
MET OXT HXT  sing N N 284 
NAG C1  C2   sing N N 285 
NAG C1  O1   sing N N 286 
NAG C1  O5   sing N N 287 
NAG C1  H1   sing N N 288 
NAG C2  C3   sing N N 289 
NAG C2  N2   sing N N 290 
NAG C2  H2   sing N N 291 
NAG C3  C4   sing N N 292 
NAG C3  O3   sing N N 293 
NAG C3  H3   sing N N 294 
NAG C4  C5   sing N N 295 
NAG C4  O4   sing N N 296 
NAG C4  H4   sing N N 297 
NAG C5  C6   sing N N 298 
NAG C5  O5   sing N N 299 
NAG C5  H5   sing N N 300 
NAG C6  O6   sing N N 301 
NAG C6  H61  sing N N 302 
NAG C6  H62  sing N N 303 
NAG C7  C8   sing N N 304 
NAG C7  N2   sing N N 305 
NAG C7  O7   doub N N 306 
NAG C8  H81  sing N N 307 
NAG C8  H82  sing N N 308 
NAG C8  H83  sing N N 309 
NAG N2  HN2  sing N N 310 
NAG O1  HO1  sing N N 311 
NAG O3  HO3  sing N N 312 
NAG O4  HO4  sing N N 313 
NAG O6  HO6  sing N N 314 
PHE N   CA   sing N N 315 
PHE N   H    sing N N 316 
PHE N   H2   sing N N 317 
PHE CA  C    sing N N 318 
PHE CA  CB   sing N N 319 
PHE CA  HA   sing N N 320 
PHE C   O    doub N N 321 
PHE C   OXT  sing N N 322 
PHE CB  CG   sing N N 323 
PHE CB  HB2  sing N N 324 
PHE CB  HB3  sing N N 325 
PHE CG  CD1  doub Y N 326 
PHE CG  CD2  sing Y N 327 
PHE CD1 CE1  sing Y N 328 
PHE CD1 HD1  sing N N 329 
PHE CD2 CE2  doub Y N 330 
PHE CD2 HD2  sing N N 331 
PHE CE1 CZ   doub Y N 332 
PHE CE1 HE1  sing N N 333 
PHE CE2 CZ   sing Y N 334 
PHE CE2 HE2  sing N N 335 
PHE CZ  HZ   sing N N 336 
PHE OXT HXT  sing N N 337 
PRO N   CA   sing N N 338 
PRO N   CD   sing N N 339 
PRO N   H    sing N N 340 
PRO CA  C    sing N N 341 
PRO CA  CB   sing N N 342 
PRO CA  HA   sing N N 343 
PRO C   O    doub N N 344 
PRO C   OXT  sing N N 345 
PRO CB  CG   sing N N 346 
PRO CB  HB2  sing N N 347 
PRO CB  HB3  sing N N 348 
PRO CG  CD   sing N N 349 
PRO CG  HG2  sing N N 350 
PRO CG  HG3  sing N N 351 
PRO CD  HD2  sing N N 352 
PRO CD  HD3  sing N N 353 
PRO OXT HXT  sing N N 354 
SER N   CA   sing N N 355 
SER N   H    sing N N 356 
SER N   H2   sing N N 357 
SER CA  C    sing N N 358 
SER CA  CB   sing N N 359 
SER CA  HA   sing N N 360 
SER C   O    doub N N 361 
SER C   OXT  sing N N 362 
SER CB  OG   sing N N 363 
SER CB  HB2  sing N N 364 
SER CB  HB3  sing N N 365 
SER OG  HG   sing N N 366 
SER OXT HXT  sing N N 367 
THR N   CA   sing N N 368 
THR N   H    sing N N 369 
THR N   H2   sing N N 370 
THR CA  C    sing N N 371 
THR CA  CB   sing N N 372 
THR CA  HA   sing N N 373 
THR C   O    doub N N 374 
THR C   OXT  sing N N 375 
THR CB  OG1  sing N N 376 
THR CB  CG2  sing N N 377 
THR CB  HB   sing N N 378 
THR OG1 HG1  sing N N 379 
THR CG2 HG21 sing N N 380 
THR CG2 HG22 sing N N 381 
THR CG2 HG23 sing N N 382 
THR OXT HXT  sing N N 383 
TRP N   CA   sing N N 384 
TRP N   H    sing N N 385 
TRP N   H2   sing N N 386 
TRP CA  C    sing N N 387 
TRP CA  CB   sing N N 388 
TRP CA  HA   sing N N 389 
TRP C   O    doub N N 390 
TRP C   OXT  sing N N 391 
TRP CB  CG   sing N N 392 
TRP CB  HB2  sing N N 393 
TRP CB  HB3  sing N N 394 
TRP CG  CD1  doub Y N 395 
TRP CG  CD2  sing Y N 396 
TRP CD1 NE1  sing Y N 397 
TRP CD1 HD1  sing N N 398 
TRP CD2 CE2  doub Y N 399 
TRP CD2 CE3  sing Y N 400 
TRP NE1 CE2  sing Y N 401 
TRP NE1 HE1  sing N N 402 
TRP CE2 CZ2  sing Y N 403 
TRP CE3 CZ3  doub Y N 404 
TRP CE3 HE3  sing N N 405 
TRP CZ2 CH2  doub Y N 406 
TRP CZ2 HZ2  sing N N 407 
TRP CZ3 CH2  sing Y N 408 
TRP CZ3 HZ3  sing N N 409 
TRP CH2 HH2  sing N N 410 
TRP OXT HXT  sing N N 411 
TYR N   CA   sing N N 412 
TYR N   H    sing N N 413 
TYR N   H2   sing N N 414 
TYR CA  C    sing N N 415 
TYR CA  CB   sing N N 416 
TYR CA  HA   sing N N 417 
TYR C   O    doub N N 418 
TYR C   OXT  sing N N 419 
TYR CB  CG   sing N N 420 
TYR CB  HB2  sing N N 421 
TYR CB  HB3  sing N N 422 
TYR CG  CD1  doub Y N 423 
TYR CG  CD2  sing Y N 424 
TYR CD1 CE1  sing Y N 425 
TYR CD1 HD1  sing N N 426 
TYR CD2 CE2  doub Y N 427 
TYR CD2 HD2  sing N N 428 
TYR CE1 CZ   doub Y N 429 
TYR CE1 HE1  sing N N 430 
TYR CE2 CZ   sing Y N 431 
TYR CE2 HE2  sing N N 432 
TYR CZ  OH   sing N N 433 
TYR OH  HH   sing N N 434 
TYR OXT HXT  sing N N 435 
VAL N   CA   sing N N 436 
VAL N   H    sing N N 437 
VAL N   H2   sing N N 438 
VAL CA  C    sing N N 439 
VAL CA  CB   sing N N 440 
VAL CA  HA   sing N N 441 
VAL C   O    doub N N 442 
VAL C   OXT  sing N N 443 
VAL CB  CG1  sing N N 444 
VAL CB  CG2  sing N N 445 
VAL CB  HB   sing N N 446 
VAL CG1 HG11 sing N N 447 
VAL CG1 HG12 sing N N 448 
VAL CG1 HG13 sing N N 449 
VAL CG2 HG21 sing N N 450 
VAL CG2 HG22 sing N N 451 
VAL CG2 HG23 sing N N 452 
VAL OXT HXT  sing N N 453 
# 
_pdbx_audit_support.funding_organization   'UK Research and Innovation (UKRI)' 
_pdbx_audit_support.country                'United Kingdom' 
_pdbx_audit_support.grant_number           BB/X001032/1 
_pdbx_audit_support.ordinal                1 
# 
loop_
_pdbx_entity_branch_list.entity_id 
_pdbx_entity_branch_list.comp_id 
_pdbx_entity_branch_list.num 
_pdbx_entity_branch_list.hetero 
3 NAG 1 n 
3 NAG 2 n 
3 BMA 3 n 
3 MAN 4 n 
3 BMA 5 n 
3 MAN 6 n 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   5A2R 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9QA1 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.005796 
_atom_sites.fract_transf_matrix[1][2]   0.003346 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.006693 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009639 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.pdbx_scat_Z 
_atom_type.pdbx_N_electrons 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
C  6  6  2.3103  20.8439 1.0201 10.2075 1.5888 0.5687  0.8651 51.6512 0.2156   
H  1  1  0.4930  10.5109 0.3229 26.1257 0.1402 3.1424  0.0408 57.7997 0.0030   
N  7  7  12.2220 0.0057  3.1346 9.8933  2.0141 28.9975 1.1672 0.5826  -11.5379 
O  8  8  3.0487  13.2771 2.2870 5.7011  1.5464 0.3239  0.8671 32.9089 0.2508   
S  16 16 6.9054  1.4679  5.2035 22.2151 1.4379 0.2536  1.5863 56.1720 1.0422   
ZN 30 30 14.0812 3.2655  7.0352 0.2333  5.1677 10.3163 2.4112 58.7097 1.0779   
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . VAL A 1 1   ? 9.473   33.276 11.476 1 72.064  ? 19   VAL A N   1 
ATOM   2    C  CA  . VAL A 1 1   ? 10.935  33.57  11.352 1 71.347  ? 19   VAL A CA  1 
ATOM   3    C  C   . VAL A 1 1   ? 11.739  32.451 12.037 1 75.672  ? 19   VAL A C   1 
ATOM   4    O  O   . VAL A 1 1   ? 11.214  31.424 12.457 1 75.463  ? 19   VAL A O   1 
ATOM   5    C  CB  . VAL A 1 1   ? 11.233  34.995 11.899 1 79.538  ? 19   VAL A CB  1 
ATOM   6    C  CG1 . VAL A 1 1   ? 11.051  36.096 10.852 1 73.416  ? 19   VAL A CG1 1 
ATOM   7    C  CG2 . VAL A 1 1   ? 10.407  35.352 13.131 1 78.897  ? 19   VAL A CG2 1 
ATOM   8    N  N   . LYS A 1 2   ? 13.055  32.629 12.127 1 87.842  ? 20   LYS A N   1 
ATOM   9    C  CA  . LYS A 1 2   ? 13.905  31.775 12.944 1 84.815  ? 20   LYS A CA  1 
ATOM   10   C  C   . LYS A 1 2   ? 13.559  31.984 14.42  1 75.95   ? 20   LYS A C   1 
ATOM   11   O  O   . LYS A 1 2   ? 13.869  31.119 15.238 1 69.607  ? 20   LYS A O   1 
ATOM   12   C  CB  . LYS A 1 2   ? 15.407  32.084 12.766 1 94.296  ? 20   LYS A CB  1 
ATOM   13   C  CG  . LYS A 1 2   ? 16.374  30.889 12.612 1 106.885 ? 20   LYS A CG  1 
ATOM   14   C  CD  . LYS A 1 2   ? 16.854  30.617 11.184 1 111.774 ? 20   LYS A CD  1 
ATOM   15   C  CE  . LYS A 1 2   ? 16.958  29.161 10.811 1 113.795 ? 20   LYS A CE  1 
ATOM   16   N  NZ  . LYS A 1 2   ? 15.644  28.57  10.524 1 113.365 ? 20   LYS A NZ  1 
ATOM   17   N  N   . GLU A 1 3   ? 12.968  33.15  14.757 1 68.827  ? 21   GLU A N   1 
ATOM   18   C  CA  . GLU A 1 3   ? 12.694  33.534 16.141 1 59.938  ? 21   GLU A CA  1 
ATOM   19   C  C   . GLU A 1 3   ? 11.572  32.655 16.698 1 49.536  ? 21   GLU A C   1 
ATOM   20   O  O   . GLU A 1 3   ? 11.632  32.215 17.841 1 42.882  ? 21   GLU A O   1 
ATOM   21   C  CB  . GLU A 1 3   ? 12.348  35.021 16.294 1 63.129  ? 21   GLU A CB  1 
ATOM   22   C  CG  . GLU A 1 3   ? 12.699  35.598 17.669 1 67.527  ? 21   GLU A CG  1 
ATOM   23   C  CD  . GLU A 1 3   ? 11.995  36.888 18.093 1 65.834  ? 21   GLU A CD  1 
ATOM   24   O  OE1 . GLU A 1 3   ? 12.641  37.963 18.159 1 65.998  ? 21   GLU A OE1 1 
ATOM   25   O  OE2 . GLU A 1 3   ? 10.788  36.818 18.398 1 53.339  ? 21   GLU A OE2 1 
ATOM   26   N  N   . GLU A 1 4   ? 10.58   32.346 15.861 1 46.855  ? 22   GLU A N   1 
ATOM   27   C  CA  . GLU A 1 4   ? 9.476   31.496 16.262 1 48.616  ? 22   GLU A CA  1 
ATOM   28   C  C   . GLU A 1 4   ? 9.939   30.065 16.581 1 48.506  ? 22   GLU A C   1 
ATOM   29   O  O   . GLU A 1 4   ? 9.347   29.399 17.422 1 48.046  ? 22   GLU A O   1 
ATOM   30   C  CB  . GLU A 1 4   ? 8.44    31.613 15.15  1 46.918  ? 22   GLU A CB  1 
ATOM   31   C  CG  . GLU A 1 4   ? 7.095   31.03  15.549 1 47.615  ? 22   GLU A CG  1 
ATOM   32   C  CD  . GLU A 1 4   ? 6.009   31.348 14.553 1 46.337  ? 22   GLU A CD  1 
ATOM   33   O  OE1 . GLU A 1 4   ? 6.203   32.264 13.74  1 47.384  ? 22   GLU A OE1 1 
ATOM   34   O  OE2 . GLU A 1 4   ? 4.97    30.67  14.593 1 53.492  ? 22   GLU A OE2 1 
ATOM   35   N  N   . ILE A 1 5   ? 11.007  29.594 15.925 1 54.085  ? 23   ILE A N   1 
ATOM   36   C  CA  . ILE A 1 5   ? 11.625  28.308 16.232 1 51.822  ? 23   ILE A CA  1 
ATOM   37   C  C   . ILE A 1 5   ? 12.289  28.383 17.609 1 44.633  ? 23   ILE A C   1 
ATOM   38   O  O   . ILE A 1 5   ? 12.051  27.523 18.44  1 46.696  ? 23   ILE A O   1 
ATOM   39   C  CB  . ILE A 1 5   ? 12.593  27.872 15.108 1 58.673  ? 23   ILE A CB  1 
ATOM   40   C  CG1 . ILE A 1 5   ? 11.819  27.365 13.866 1 60.877  ? 23   ILE A CG1 1 
ATOM   41   C  CG2 . ILE A 1 5   ? 13.606  26.828 15.594 1 55.613  ? 23   ILE A CG2 1 
ATOM   42   C  CD1 . ILE A 1 5   ? 12.604  27.42  12.56  1 59.319  ? 23   ILE A CD1 1 
ATOM   43   N  N   . GLN A 1 6   ? 13.091  29.406 17.896 1 46.059  ? 24   GLN A N   1 
ATOM   44   C  CA  . GLN A 1 6   ? 13.655  29.52  19.233 1 53.735  ? 24   GLN A CA  1 
ATOM   45   C  C   . GLN A 1 6   ? 12.555  29.653 20.281 1 52.427  ? 24   GLN A C   1 
ATOM   46   O  O   . GLN A 1 6   ? 12.716  29.187 21.402 1 50.564  ? 24   GLN A O   1 
ATOM   47   C  CB  . GLN A 1 6   ? 14.548  30.738 19.439 1 64.929  ? 24   GLN A CB  1 
ATOM   48   C  CG  . GLN A 1 6   ? 16.009  30.491 19.097 1 86.782  ? 24   GLN A CG  1 
ATOM   49   C  CD  . GLN A 1 6   ? 16.738  31.756 18.699 1 101.87  ? 24   GLN A CD  1 
ATOM   50   O  OE1 . GLN A 1 6   ? 17.878  31.703 18.223 1 108.958 ? 24   GLN A OE1 1 
ATOM   51   N  NE2 . GLN A 1 6   ? 16.084  32.901 18.864 1 94.799  ? 24   GLN A NE2 1 
ATOM   52   N  N   . ALA A 1 7   ? 11.467  30.355 19.936 1 54.696  ? 25   ALA A N   1 
ATOM   53   C  CA  . ALA A 1 7   ? 10.427  30.669 20.908 1 50.555  ? 25   ALA A CA  1 
ATOM   54   C  C   . ALA A 1 7   ? 9.759   29.388 21.387 1 43.95   ? 25   ALA A C   1 
ATOM   55   O  O   . ALA A 1 7   ? 9.552   29.24  22.582 1 39.083  ? 25   ALA A O   1 
ATOM   56   C  CB  . ALA A 1 7   ? 9.412   31.611 20.325 1 50.87   ? 25   ALA A CB  1 
ATOM   57   N  N   . LYS A 1 8   ? 9.473   28.478 20.447 1 39.673  ? 26   LYS A N   1 
ATOM   58   C  CA  . LYS A 1 8   ? 8.882   27.187 20.755 1 45.14   ? 26   LYS A CA  1 
ATOM   59   C  C   . LYS A 1 8   ? 9.75    26.405 21.739 1 45.091  ? 26   LYS A C   1 
ATOM   60   O  O   . LYS A 1 8   ? 9.224   25.698 22.582 1 44.694  ? 26   LYS A O   1 
ATOM   61   C  CB  . LYS A 1 8   ? 8.659   26.335 19.502 1 49.1    ? 26   LYS A CB  1 
ATOM   62   C  CG  . LYS A 1 8   ? 8.039   24.955 19.778 1 59.29   ? 26   LYS A CG  1 
ATOM   63   C  CD  . LYS A 1 8   ? 8.396   23.884 18.753 1 70.367  ? 26   LYS A CD  1 
ATOM   64   C  CE  . LYS A 1 8   ? 7.838   24.161 17.395 1 72.553  ? 26   LYS A CE  1 
ATOM   65   N  NZ  . LYS A 1 8   ? 6.502   23.571 17.341 1 76.199  ? 26   LYS A NZ  1 
ATOM   66   N  N   . GLU A 1 9   ? 11.072  26.53  21.636 1 47.294  ? 27   GLU A N   1 
ATOM   67   C  CA  . GLU A 1 9   ? 11.966  25.853 22.554 1 49.666  ? 27   GLU A CA  1 
ATOM   68   C  C   . GLU A 1 9   ? 12.021  26.581 23.887 1 43.062  ? 27   GLU A C   1 
ATOM   69   O  O   . GLU A 1 9   ? 12.143  25.931 24.925 1 39.652  ? 27   GLU A O   1 
ATOM   70   C  CB  . GLU A 1 9   ? 13.384  25.691 22.011 1 60.605  ? 27   GLU A CB  1 
ATOM   71   C  CG  . GLU A 1 9   ? 13.473  24.542 21.012 1 78.514  ? 27   GLU A CG  1 
ATOM   72   C  CD  . GLU A 1 9   ? 14.699  24.58  20.112 1 95.722  ? 27   GLU A CD  1 
ATOM   73   O  OE1 . GLU A 1 9   ? 15.658  25.343 20.403 1 86.357  ? 27   GLU A OE1 1 
ATOM   74   O  OE2 . GLU A 1 9   ? 14.663  23.857 19.088 1 99.585  ? 27   GLU A OE2 1 
ATOM   75   N  N   . TYR A 1 10  ? 11.975  27.914 23.862 1 39.771  ? 28   TYR A N   1 
ATOM   76   C  CA  . TYR A 1 10  ? 11.827  28.669 25.099 1 42.519  ? 28   TYR A CA  1 
ATOM   77   C  C   . TYR A 1 10  ? 10.6    28.171 25.879 1 40.108  ? 28   TYR A C   1 
ATOM   78   O  O   . TYR A 1 10  ? 10.668  27.979 27.093 1 37.01   ? 28   TYR A O   1 
ATOM   79   C  CB  . TYR A 1 10  ? 11.755  30.171 24.808 1 43.927  ? 28   TYR A CB  1 
ATOM   80   C  CG  . TYR A 1 10  ? 11.562  31.032 26.047 1 46.298  ? 28   TYR A CG  1 
ATOM   81   C  CD1 . TYR A 1 10  ? 12.637  31.344 26.872 1 48.554  ? 28   TYR A CD1 1 
ATOM   82   C  CD2 . TYR A 1 10  ? 10.313  31.553 26.378 1 46.571  ? 28   TYR A CD2 1 
ATOM   83   C  CE1 . TYR A 1 10  ? 12.471  32.116 28.01  1 47.282  ? 28   TYR A CE1 1 
ATOM   84   C  CE2 . TYR A 1 10  ? 10.137  32.333 27.509 1 45.509  ? 28   TYR A CE2 1 
ATOM   85   C  CZ  . TYR A 1 10  ? 11.218  32.604 28.326 1 50.086  ? 28   TYR A CZ  1 
ATOM   86   O  OH  . TYR A 1 10  ? 11.065  33.349 29.453 1 65.536  ? 28   TYR A OH  1 
ATOM   87   N  N   . LEU A 1 11  ? 9.475   27.94  25.186 1 39.56   ? 29   LEU A N   1 
ATOM   88   C  CA  . LEU A 1 11  ? 8.208   27.668 25.857 1 42.784  ? 29   LEU A CA  1 
ATOM   89   C  C   . LEU A 1 11  ? 8.249   26.268 26.456 1 46.99   ? 29   LEU A C   1 
ATOM   90   O  O   . LEU A 1 11  ? 7.885   26.086 27.624 1 40.163  ? 29   LEU A O   1 
ATOM   91   C  CB  . LEU A 1 11  ? 6.988   27.828 24.946 1 40.26   ? 29   LEU A CB  1 
ATOM   92   C  CG  . LEU A 1 11  ? 6.635   29.261 24.523 1 40.095  ? 29   LEU A CG  1 
ATOM   93   C  CD1 . LEU A 1 11  ? 5.591   29.201 23.439 1 41.781  ? 29   LEU A CD1 1 
ATOM   94   C  CD2 . LEU A 1 11  ? 6.173   30.153 25.668 1 42.256  ? 29   LEU A CD2 1 
ATOM   95   N  N   . GLU A 1 12  ? 8.666   25.302 25.623 1 50.839  ? 30   GLU A N   1 
ATOM   96   C  CA  . GLU A 1 12  ? 8.77    23.913 26.034 1 51.69   ? 30   GLU A CA  1 
ATOM   97   C  C   . GLU A 1 12  ? 9.527   23.829 27.356 1 44.209  ? 30   GLU A C   1 
ATOM   98   O  O   . GLU A 1 12  ? 9.03    23.245 28.313 1 46.968  ? 30   GLU A O   1 
ATOM   99   C  CB  . GLU A 1 12  ? 9.378   23.043 24.94  1 57.595  ? 30   GLU A CB  1 
ATOM   100  C  CG  . GLU A 1 12  ? 9.266   21.557 25.282 1 78.63   ? 30   GLU A CG  1 
ATOM   101  C  CD  . GLU A 1 12  ? 9.024   20.585 24.132 1 91.262  ? 30   GLU A CD  1 
ATOM   102  O  OE1 . GLU A 1 12  ? 9.04    20.983 22.934 1 89.981  ? 30   GLU A OE1 1 
ATOM   103  O  OE2 . GLU A 1 12  ? 8.794   19.399 24.475 1 79.479  ? 30   GLU A OE2 1 
ATOM   104  N  N   . ASN A 1 13  ? 10.667  24.512 27.431 1 42.051  ? 31   ASN A N   1 
ATOM   105  C  CA  . ASN A 1 13  ? 11.54   24.476 28.594 1 47.746  ? 31   ASN A CA  1 
ATOM   106  C  C   . ASN A 1 13  ? 10.921  25.202 29.796 1 41.265  ? 31   ASN A C   1 
ATOM   107  O  O   . ASN A 1 13  ? 10.994  24.724 30.925 1 45.807  ? 31   ASN A O   1 
ATOM   108  C  CB  . ASN A 1 13  ? 12.91   25.058 28.243 1 56.313  ? 31   ASN A CB  1 
ATOM   109  C  CG  . ASN A 1 13  ? 13.802  25.116 29.463 1 67.729  ? 31   ASN A CG  1 
ATOM   110  O  OD1 . ASN A 1 13  ? 13.843  26.137 30.169 1 63.232  ? 31   ASN A OD1 1 
ATOM   111  N  ND2 . ASN A 1 13  ? 14.452  24.004 29.776 1 71.253  ? 31   ASN A ND2 1 
ATOM   112  N  N   . LEU A 1 14  ? 10.346  26.386 29.563 1 39.342  ? 32   LEU A N   1 
ATOM   113  C  CA  . LEU A 1 14  ? 9.775   27.213 30.615 1 40.581  ? 32   LEU A CA  1 
ATOM   114  C  C   . LEU A 1 14  ? 8.531   26.557 31.215 1 36.916  ? 32   LEU A C   1 
ATOM   115  O  O   . LEU A 1 14  ? 8.3     26.624 32.422 1 30.698  ? 32   LEU A O   1 
ATOM   116  C  CB  . LEU A 1 14  ? 9.396   28.567 30.027 1 42.748  ? 32   LEU A CB  1 
ATOM   117  C  CG  . LEU A 1 14  ? 8.631   29.478 30.979 1 42.079  ? 32   LEU A CG  1 
ATOM   118  C  CD1 . LEU A 1 14  ? 9.543   29.89  32.109 1 46.057  ? 32   LEU A CD1 1 
ATOM   119  C  CD2 . LEU A 1 14  ? 8.119   30.66  30.242 1 46.442  ? 32   LEU A CD2 1 
ATOM   120  N  N   . ASN A 1 15  ? 7.711   25.955 30.357 1 34.457  ? 33   ASN A N   1 
ATOM   121  C  CA  . ASN A 1 15  ? 6.569   25.187 30.835 1 42.866  ? 33   ASN A CA  1 
ATOM   122  C  C   . ASN A 1 15  ? 7.012   24.15  31.878 1 42.374  ? 33   ASN A C   1 
ATOM   123  O  O   . ASN A 1 15  ? 6.508   24.16  33.001 1 41.043  ? 33   ASN A O   1 
ATOM   124  C  CB  . ASN A 1 15  ? 5.741   24.652 29.668 1 43.615  ? 33   ASN A CB  1 
ATOM   125  C  CG  . ASN A 1 15  ? 4.694   25.644 29.205 1 44.476  ? 33   ASN A CG  1 
ATOM   126  O  OD1 . ASN A 1 15  ? 3.906   26.129 30.025 1 45.555  ? 33   ASN A OD1 1 
ATOM   127  N  ND2 . ASN A 1 15  ? 4.627   25.93  27.912 1 45.109  ? 33   ASN A ND2 1 
ATOM   128  N  N   . LYS A 1 16  ? 7.987   23.294 31.546 1 43.777  ? 34   LYS A N   1 
ATOM   129  C  CA  . LYS A 1 16  ? 8.481   22.287 32.485 1 46.047  ? 34   LYS A CA  1 
ATOM   130  C  C   . LYS A 1 16  ? 8.991   22.916 33.78  1 42.147  ? 34   LYS A C   1 
ATOM   131  O  O   . LYS A 1 16  ? 8.766   22.405 34.867 1 46.62   ? 34   LYS A O   1 
ATOM   132  C  CB  . LYS A 1 16  ? 9.527   21.379 31.824 1 53.049  ? 34   LYS A CB  1 
ATOM   133  C  CG  . LYS A 1 16  ? 8.886   20.488 30.742 1 61.478  ? 34   LYS A CG  1 
ATOM   134  C  CD  . LYS A 1 16  ? 9.817   19.752 29.79  1 75.317  ? 34   LYS A CD  1 
ATOM   135  C  CE  . LYS A 1 16  ? 11.052  20.534 29.423 1 82.559  ? 34   LYS A CE  1 
ATOM   136  N  NZ  . LYS A 1 16  ? 11.662  20.018 28.195 1 87.067  ? 34   LYS A NZ  1 
ATOM   137  N  N   . GLU A 1 17  ? 9.664   24.055 33.691 1 40.275  ? 35   GLU A N   1 
ATOM   138  C  CA  . GLU A 1 17  ? 10.16   24.707 34.891 1 36.639  ? 35   GLU A CA  1 
ATOM   139  C  C   . GLU A 1 17  ? 9.013   25.23  35.772 1 35.246  ? 35   GLU A C   1 
ATOM   140  O  O   . GLU A 1 17  ? 9.073   25.127 37     1 39.332  ? 35   GLU A O   1 
ATOM   141  C  CB  . GLU A 1 17  ? 11.209  25.721 34.427 1 36.974  ? 35   GLU A CB  1 
ATOM   142  C  CG  . GLU A 1 17  ? 11.465  26.811 35.457 1 43.157  ? 35   GLU A CG  1 
ATOM   143  C  CD  . GLU A 1 17  ? 12.859  27.409 35.478 1 49.021  ? 35   GLU A CD  1 
ATOM   144  O  OE1 . GLU A 1 17  ? 13.373  27.69  34.368 1 49.133  ? 35   GLU A OE1 1 
ATOM   145  O  OE2 . GLU A 1 17  ? 13.375  27.629 36.62  1 46.875  ? 35   GLU A OE2 1 
ATOM   146  N  N   . LEU A 1 18  ? 7.988   25.838 35.169 1 32.841  ? 36   LEU A N   1 
ATOM   147  C  CA  . LEU A 1 18  ? 6.837   26.318 35.92  1 36.271  ? 36   LEU A CA  1 
ATOM   148  C  C   . LEU A 1 18  ? 6.111   25.144 36.587 1 31.898  ? 36   LEU A C   1 
ATOM   149  O  O   . LEU A 1 18  ? 5.763   25.222 37.757 1 30.123  ? 36   LEU A O   1 
ATOM   150  C  CB  . LEU A 1 18  ? 5.901   27.115 35.005 1 41.266  ? 36   LEU A CB  1 
ATOM   151  C  CG  . LEU A 1 18  ? 6.37    28.517 34.598 1 44.683  ? 36   LEU A CG  1 
ATOM   152  C  CD1 . LEU A 1 18  ? 5.607   29.077 33.396 1 43.187  ? 36   LEU A CD1 1 
ATOM   153  C  CD2 . LEU A 1 18  ? 6.229   29.454 35.773 1 47.557  ? 36   LEU A CD2 1 
ATOM   154  N  N   . ALA A 1 19  ? 5.911   24.035 35.873 1 31.889  ? 37   ALA A N   1 
ATOM   155  C  CA  . ALA A 1 19  ? 5.308   22.855 36.493 1 33.495  ? 37   ALA A CA  1 
ATOM   156  C  C   . ALA A 1 19  ? 6.067   22.5   37.767 1 35.808  ? 37   ALA A C   1 
ATOM   157  O  O   . ALA A 1 19  ? 5.479   22.371 38.836 1 40.338  ? 37   ALA A O   1 
ATOM   158  C  CB  . ALA A 1 19  ? 5.256   21.697 35.53  1 33.383  ? 37   ALA A CB  1 
ATOM   159  N  N   . LYS A 1 20  ? 7.397   22.459 37.686 1 38.147  ? 38   LYS A N   1 
ATOM   160  C  CA  . LYS A 1 20  ? 8.177   21.964 38.799 1 37.29   ? 38   LYS A CA  1 
ATOM   161  C  C   . LYS A 1 20  ? 8.113   22.966 39.949 1 34.67   ? 38   LYS A C   1 
ATOM   162  O  O   . LYS A 1 20  ? 8       22.574 41.106 1 36.861  ? 38   LYS A O   1 
ATOM   163  C  CB  . LYS A 1 20  ? 9.569   21.529 38.302 1 43.245  ? 38   LYS A CB  1 
ATOM   164  C  CG  . LYS A 1 20  ? 10.344  20.674 39.305 1 45.856  ? 38   LYS A CG  1 
ATOM   165  C  CD  . LYS A 1 20  ? 10.03   19.178 39.336 1 49.513  ? 38   LYS A CD  1 
ATOM   166  C  CE  . LYS A 1 20  ? 10.685  18.369 40.466 1 53.081  ? 38   LYS A CE  1 
ATOM   167  N  NZ  . LYS A 1 20  ? 10.053  18.613 41.785 1 57.675  ? 38   LYS A NZ  1 
ATOM   168  N  N   . ARG A 1 21  ? 8.212   24.263 39.653 1 39.181  ? 39   ARG A N   1 
ATOM   169  C  CA  . ARG A 1 21  ? 8.095   25.259 40.703 1 36.915  ? 39   ARG A CA  1 
ATOM   170  C  C   . ARG A 1 21  ? 6.679   25.294 41.266 1 34.954  ? 39   ARG A C   1 
ATOM   171  O  O   . ARG A 1 21  ? 6.506   25.519 42.451 1 34.653  ? 39   ARG A O   1 
ATOM   172  C  CB  . ARG A 1 21  ? 8.407   26.668 40.219 1 42.977  ? 39   ARG A CB  1 
ATOM   173  C  CG  . ARG A 1 21  ? 9.885   26.882 39.956 1 45.512  ? 39   ARG A CG  1 
ATOM   174  C  CD  . ARG A 1 21  ? 10.056  28.214 39.283 1 47.291  ? 39   ARG A CD  1 
ATOM   175  N  NE  . ARG A 1 21  ? 11.437  28.366 38.83  1 47.86   ? 39   ARG A NE  1 
ATOM   176  C  CZ  . ARG A 1 21  ? 12.351  29.04  39.51  1 42.05   ? 39   ARG A CZ  1 
ATOM   177  N  NH1 . ARG A 1 21  ? 12.005  29.626 40.63  1 34.546  ? 39   ARG A NH1 1 
ATOM   178  N  NH2 . ARG A 1 21  ? 13.598  29.093 39.077 1 41.325  ? 39   ARG A NH2 1 
ATOM   179  N  N   . THR A 1 22  ? 5.658   25.083 40.436 1 37.042  ? 40   THR A N   1 
ATOM   180  C  CA  . THR A 1 22  ? 4.294   25.075 40.955 1 41.909  ? 40   THR A CA  1 
ATOM   181  C  C   . THR A 1 22  ? 4.102   23.88  41.898 1 42.887  ? 40   THR A C   1 
ATOM   182  O  O   . THR A 1 22  ? 3.45    24.022 42.934 1 37.352  ? 40   THR A O   1 
ATOM   183  C  CB  . THR A 1 22  ? 3.245   25.051 39.84  1 43.736  ? 40   THR A CB  1 
ATOM   184  O  OG1 . THR A 1 22  ? 3.496   26.143 38.96  1 40.191  ? 40   THR A OG1 1 
ATOM   185  C  CG2 . THR A 1 22  ? 1.837   25.233 40.391 1 43.904  ? 40   THR A CG2 1 
ATOM   186  N  N   . ASN A 1 23  ? 4.671   22.714 41.52  1 41.813  ? 41   ASN A N   1 
ATOM   187  C  CA  . ASN A 1 23  ? 4.667   21.508 42.339 1 35.976  ? 41   ASN A CA  1 
ATOM   188  C  C   . ASN A 1 23  ? 5.046   21.837 43.78  1 35.506  ? 41   ASN A C   1 
ATOM   189  O  O   . ASN A 1 23  ? 4.395   21.411 44.725 1 37.157  ? 41   ASN A O   1 
ATOM   190  C  CB  . ASN A 1 23  ? 5.612   20.444 41.792 1 36.091  ? 41   ASN A CB  1 
ATOM   191  C  CG  . ASN A 1 23  ? 5.711   19.255 42.722 1 36.138  ? 41   ASN A CG  1 
ATOM   192  O  OD1 . ASN A 1 23  ? 6.6     19.204 43.581 1 39.731  ? 41   ASN A OD1 1 
ATOM   193  N  ND2 . ASN A 1 23  ? 4.759   18.341 42.63  1 34.362  ? 41   ASN A ND2 1 
ATOM   194  N  N   . VAL A 1 24  ? 6.121   22.601 43.942 1 35.05   ? 42   VAL A N   1 
ATOM   195  C  CA  . VAL A 1 24  ? 6.647   22.878 45.263 1 37.118  ? 42   VAL A CA  1 
ATOM   196  C  C   . VAL A 1 24  ? 5.718   23.83  46.006 1 36.656  ? 42   VAL A C   1 
ATOM   197  O  O   . VAL A 1 24  ? 5.657   23.78  47.223 1 39.081  ? 42   VAL A O   1 
ATOM   198  C  CB  . VAL A 1 24  ? 8.073   23.438 45.067 1 40.576  ? 42   VAL A CB  1 
ATOM   199  C  CG1 . VAL A 1 24  ? 8.621   24.124 46.306 1 40.956  ? 42   VAL A CG1 1 
ATOM   200  C  CG2 . VAL A 1 24  ? 9.023   22.352 44.578 1 46.035  ? 42   VAL A CG2 1 
ATOM   201  N  N   . GLU A 1 25  ? 5.055   24.752 45.288 1 40.211  ? 43   GLU A N   1 
ATOM   202  C  CA  . GLU A 1 25  ? 4.133   25.673 45.938 1 43.961  ? 43   GLU A CA  1 
ATOM   203  C  C   . GLU A 1 25  ? 2.878   24.898 46.356 1 37.08   ? 43   GLU A C   1 
ATOM   204  O  O   . GLU A 1 25  ? 2.394   25.065 47.481 1 30.243  ? 43   GLU A O   1 
ATOM   205  C  CB  . GLU A 1 25  ? 3.778   26.897 45.092 1 50.329  ? 43   GLU A CB  1 
ATOM   206  C  CG  . GLU A 1 25  ? 2.624   27.719 45.677 1 56.533  ? 43   GLU A CG  1 
ATOM   207  C  CD  . GLU A 1 25  ? 1.897   28.614 44.677 1 61.369  ? 43   GLU A CD  1 
ATOM   208  O  OE1 . GLU A 1 25  ? 1.464   28.096 43.61  1 53.409  ? 43   GLU A OE1 1 
ATOM   209  O  OE2 . GLU A 1 25  ? 1.766   29.834 44.967 1 52.464  ? 43   GLU A OE2 1 
ATOM   210  N  N   . THR A 1 26  ? 2.383   24.033 45.464 1 31.95   ? 44   THR A N   1 
ATOM   211  C  CA  . THR A 1 26  ? 1.214   23.222 45.769 1 34.737  ? 44   THR A CA  1 
ATOM   212  C  C   . THR A 1 26  ? 1.468   22.327 46.983 1 36.715  ? 44   THR A C   1 
ATOM   213  O  O   . THR A 1 26  ? 0.595   22.229 47.842 1 33.531  ? 44   THR A O   1 
ATOM   214  C  CB  . THR A 1 26  ? 0.788   22.38  44.585 1 37.986  ? 44   THR A CB  1 
ATOM   215  O  OG1 . THR A 1 26  ? 0.786   23.268 43.472 1 37.566  ? 44   THR A OG1 1 
ATOM   216  C  CG2 . THR A 1 26  ? -0.58   21.771 44.828 1 39.996  ? 44   THR A CG2 1 
ATOM   217  N  N   . GLU A 1 27  ? 2.662   21.726 47.094 1 35.88   ? 45   GLU A N   1 
ATOM   218  C  CA  . GLU A 1 27  ? 2.964   20.862 48.228 1 34.755  ? 45   GLU A CA  1 
ATOM   219  C  C   . GLU A 1 27  ? 2.87    21.651 49.516 1 31.448  ? 45   GLU A C   1 
ATOM   220  O  O   . GLU A 1 27  ? 2.382   21.155 50.52  1 35.561  ? 45   GLU A O   1 
ATOM   221  C  CB  . GLU A 1 27  ? 4.364   20.238 48.262 1 40.735  ? 45   GLU A CB  1 
ATOM   222  C  CG  . GLU A 1 27  ? 4.516   19.018 47.363 1 44.463  ? 45   GLU A CG  1 
ATOM   223  C  CD  . GLU A 1 27  ? 3.865   17.717 47.84  1 50.068  ? 45   GLU A CD  1 
ATOM   224  O  OE1 . GLU A 1 27  ? 3.292   17.62  48.975 1 46.96   ? 45   GLU A OE1 1 
ATOM   225  O  OE2 . GLU A 1 27  ? 3.979   16.771 47.008 1 43.784  ? 45   GLU A OE2 1 
ATOM   226  N  N   . ALA A 1 28  ? 3.366   22.884 49.517 1 34.445  ? 46   ALA A N   1 
ATOM   227  C  CA  . ALA A 1 28  ? 3.363   23.619 50.774 1 36.943  ? 46   ALA A CA  1 
ATOM   228  C  C   . ALA A 1 28  ? 1.94    24.09  51.123 1 34.576  ? 46   ALA A C   1 
ATOM   229  O  O   . ALA A 1 28  ? 1.591   24.167 52.298 1 34.607  ? 46   ALA A O   1 
ATOM   230  C  CB  . ALA A 1 28  ? 4.397   24.726 50.725 1 36.264  ? 46   ALA A CB  1 
ATOM   231  N  N   . ALA A 1 29  ? 1.132   24.414 50.106 1 32.132  ? 47   ALA A N   1 
ATOM   232  C  CA  . ALA A 1 29  ? -0.269  24.804 50.283 1 36.305  ? 47   ALA A CA  1 
ATOM   233  C  C   . ALA A 1 29  ? -1.069  23.623 50.83  1 34.542  ? 47   ALA A C   1 
ATOM   234  O  O   . ALA A 1 29  ? -1.92   23.78  51.689 1 30.631  ? 47   ALA A O   1 
ATOM   235  C  CB  . ALA A 1 29  ? -0.846  25.262 48.95  1 33.488  ? 47   ALA A CB  1 
ATOM   236  N  N   . TRP A 1 30  ? -0.782  22.437 50.284 1 35.909  ? 48   TRP A N   1 
ATOM   237  C  CA  . TRP A 1 30  ? -1.415  21.203 50.716 1 35.009  ? 48   TRP A CA  1 
ATOM   238  C  C   . TRP A 1 30  ? -1.146  20.99  52.197 1 38.285  ? 48   TRP A C   1 
ATOM   239  O  O   . TRP A 1 30  ? -2.05   20.695 52.966 1 40.247  ? 48   TRP A O   1 
ATOM   240  C  CB  . TRP A 1 30  ? -0.898  20.027 49.884 1 36.676  ? 48   TRP A CB  1 
ATOM   241  C  CG  . TRP A 1 30  ? -1.256  18.677 50.443 1 38.683  ? 48   TRP A CG  1 
ATOM   242  C  CD1 . TRP A 1 30  ? -0.491  17.926 51.283 1 37.847  ? 48   TRP A CD1 1 
ATOM   243  C  CD2 . TRP A 1 30  ? -2.466  17.931 50.22  1 35.284  ? 48   TRP A CD2 1 
ATOM   244  N  NE1 . TRP A 1 30  ? -1.132  16.76  51.586 1 41.141  ? 48   TRP A NE1 1 
ATOM   245  C  CE2 . TRP A 1 30  ? -2.341  16.73  50.949 1 38.323  ? 48   TRP A CE2 1 
ATOM   246  C  CE3 . TRP A 1 30  ? -3.633  18.151 49.485 1 36.732  ? 48   TRP A CE3 1 
ATOM   247  C  CZ2 . TRP A 1 30  ? -3.34   15.762 50.963 1 37.092  ? 48   TRP A CZ2 1 
ATOM   248  C  CZ3 . TRP A 1 30  ? -4.621  17.189 49.489 1 36.32   ? 48   TRP A CZ3 1 
ATOM   249  C  CH2 . TRP A 1 30  ? -4.483  16.018 50.236 1 37.701  ? 48   TRP A CH2 1 
ATOM   250  N  N   . ALA A 1 31  ? 0.11    21.2   52.587 1 39.561  ? 49   ALA A N   1 
ATOM   251  C  CA  . ALA A 1 31  ? 0.548   20.917 53.935 1 35.675  ? 49   ALA A CA  1 
ATOM   252  C  C   . ALA A 1 31  ? -0.17   21.833 54.911 1 39.381  ? 49   ALA A C   1 
ATOM   253  O  O   . ALA A 1 31  ? -0.41   21.462 56.057 1 47.907  ? 49   ALA A O   1 
ATOM   254  C  CB  . ALA A 1 31  ? 2.042   21.105 54.018 1 35.427  ? 49   ALA A CB  1 
ATOM   255  N  N   . TYR A 1 32  ? -0.459  23.053 54.459 1 38.967  ? 50   TYR A N   1 
ATOM   256  C  CA  . TYR A 1 32  ? -1.061  24.039 55.336 1 39.727  ? 50   TYR A CA  1 
ATOM   257  C  C   . TYR A 1 32  ? -2.535  23.701 55.458 1 36.263  ? 50   TYR A C   1 
ATOM   258  O  O   . TYR A 1 32  ? -3.102  23.71  56.553 1 33.213  ? 50   TYR A O   1 
ATOM   259  C  CB  . TYR A 1 32  ? -0.872  25.455 54.791 1 42.041  ? 50   TYR A CB  1 
ATOM   260  C  CG  . TYR A 1 32  ? -1.67   26.537 55.505 1 45.547  ? 50   TYR A CG  1 
ATOM   261  C  CD1 . TYR A 1 32  ? -1.301  26.96  56.77  1 45.881  ? 50   TYR A CD1 1 
ATOM   262  C  CD2 . TYR A 1 32  ? -2.762  27.161 54.906 1 49.908  ? 50   TYR A CD2 1 
ATOM   263  C  CE1 . TYR A 1 32  ? -1.996  27.956 57.434 1 50.626  ? 50   TYR A CE1 1 
ATOM   264  C  CE2 . TYR A 1 32  ? -3.465  28.162 55.563 1 53.104  ? 50   TYR A CE2 1 
ATOM   265  C  CZ  . TYR A 1 32  ? -3.079  28.564 56.83  1 51.825  ? 50   TYR A CZ  1 
ATOM   266  O  OH  . TYR A 1 32  ? -3.706  29.55  57.534 1 53.055  ? 50   TYR A OH  1 
ATOM   267  N  N   . GLY A 1 33  ? -3.13   23.421 54.298 1 33.634  ? 51   GLY A N   1 
ATOM   268  C  CA  . GLY A 1 33  ? -4.555  23.183 54.219 1 35.506  ? 51   GLY A CA  1 
ATOM   269  C  C   . GLY A 1 33  ? -4.944  21.913 54.964 1 35.618  ? 51   GLY A C   1 
ATOM   270  O  O   . GLY A 1 33  ? -6.082  21.771 55.383 1 36.348  ? 51   GLY A O   1 
ATOM   271  N  N   . SER A 1 34  ? -4.007  20.977 55.111 1 36.65   ? 52   SER A N   1 
ATOM   272  C  CA  . SER A 1 34  ? -4.319  19.734 55.796 1 38.671  ? 52   SER A CA  1 
ATOM   273  C  C   . SER A 1 34  ? -3.818  19.749 57.237 1 36.079  ? 52   SER A C   1 
ATOM   274  O  O   . SER A 1 34  ? -3.959  18.734 57.902 1 36.815  ? 52   SER A O   1 
ATOM   275  C  CB  . SER A 1 34  ? -3.771  18.564 55.037 1 38.756  ? 52   SER A CB  1 
ATOM   276  O  OG  . SER A 1 34  ? -2.361  18.631 55.068 1 49.739  ? 52   SER A OG  1 
ATOM   277  N  N   . ASN A 1 35  ? -3.273  20.89  57.708 1 38.417  ? 53   ASN A N   1 
ATOM   278  C  CA  . ASN A 1 35  ? -2.622  21.014 59.01  1 39.706  ? 53   ASN A CA  1 
ATOM   279  C  C   . ASN A 1 35  ? -2.233  22.471 59.234 1 42.821  ? 53   ASN A C   1 
ATOM   280  O  O   . ASN A 1 35  ? -1.1    22.877 58.965 1 49.625  ? 53   ASN A O   1 
ATOM   281  C  CB  . ASN A 1 35  ? -1.38   20.126 59.12  1 44.317  ? 53   ASN A CB  1 
ATOM   282  C  CG  . ASN A 1 35  ? -0.58   20.172 60.433 1 50.426  ? 53   ASN A CG  1 
ATOM   283  O  OD1 . ASN A 1 35  ? -1.1    20.517 61.497 1 42.311  ? 53   ASN A OD1 1 
ATOM   284  N  ND2 . ASN A 1 35  ? 0.688   19.788 60.353 1 62.272  ? 53   ASN A ND2 1 
ATOM   285  N  N   . ILE A 1 36  ? -3.175  23.26  59.738 1 42.209  ? 54   ILE A N   1 
ATOM   286  C  CA  . ILE A 1 36  ? -2.993  24.695 59.873 1 44.183  ? 54   ILE A CA  1 
ATOM   287  C  C   . ILE A 1 36  ? -2.164  25.018 61.117 1 45.129  ? 54   ILE A C   1 
ATOM   288  O  O   . ILE A 1 36  ? -2.627  24.847 62.238 1 52.611  ? 54   ILE A O   1 
ATOM   289  C  CB  . ILE A 1 36  ? -4.375  25.369 59.912 1 47.275  ? 54   ILE A CB  1 
ATOM   290  C  CG1 . ILE A 1 36  ? -5.034  25.299 58.527 1 44.468  ? 54   ILE A CG1 1 
ATOM   291  C  CG2 . ILE A 1 36  ? -4.305  26.803 60.463 1 44.772  ? 54   ILE A CG2 1 
ATOM   292  C  CD1 . ILE A 1 36  ? -6.524  25.558 58.561 1 45.904  ? 54   ILE A CD1 1 
ATOM   293  N  N   . THR A 1 37  ? -0.954  25.532 60.898 1 46.154  ? 55   THR A N   1 
ATOM   294  C  CA  . THR A 1 37  ? -0.073  26.032 61.948 1 46.495  ? 55   THR A CA  1 
ATOM   295  C  C   . THR A 1 37  ? 0.607   27.295 61.432 1 46.241  ? 55   THR A C   1 
ATOM   296  O  O   . THR A 1 37  ? 0.692   27.486 60.214 1 42.798  ? 55   THR A O   1 
ATOM   297  C  CB  . THR A 1 37  ? 0.988   24.986 62.283 1 45.508  ? 55   THR A CB  1 
ATOM   298  O  OG1 . THR A 1 37  ? 1.804   24.849 61.125 1 47.873  ? 55   THR A OG1 1 
ATOM   299  C  CG2 . THR A 1 37  ? 0.415   23.609 62.552 1 47.876  ? 55   THR A CG2 1 
ATOM   300  N  N   . ASP A 1 38  ? 1.162   28.099 62.348 1 48.577  ? 56   ASP A N   1 
ATOM   301  C  CA  . ASP A 1 38  ? 1.933   29.287 61.978 1 52.863  ? 56   ASP A CA  1 
ATOM   302  C  C   . ASP A 1 38  ? 3.132   28.94  61.083 1 48.199  ? 56   ASP A C   1 
ATOM   303  O  O   . ASP A 1 38  ? 3.454   29.674 60.152 1 46.557  ? 56   ASP A O   1 
ATOM   304  C  CB  . ASP A 1 38  ? 2.257   30.123 63.205 1 54.935  ? 56   ASP A CB  1 
ATOM   305  C  CG  . ASP A 1 38  ? 1.058   30.842 63.823 1 63.427  ? 56   ASP A CG  1 
ATOM   306  O  OD1 . ASP A 1 38  ? 0.011   30.963 63.137 1 56.878  ? 56   ASP A OD1 1 
ATOM   307  O  OD2 . ASP A 1 38  ? 1.167   31.271 64.998 1 67.506  ? 56   ASP A OD2 1 
ATOM   308  N  N   . GLU A 1 39  ? 3.749   27.78  61.297 1 51.731  ? 57   GLU A N   1 
ATOM   309  C  CA  . GLU A 1 39  ? 4.958   27.428 60.578 1 55.819  ? 57   GLU A CA  1 
ATOM   310  C  C   . GLU A 1 39  ? 4.602   27.048 59.143 1 48.49   ? 57   GLU A C   1 
ATOM   311  O  O   . GLU A 1 39  ? 5.311   27.413 58.22  1 44.255  ? 57   GLU A O   1 
ATOM   312  C  CB  . GLU A 1 39  ? 5.698   26.356 61.384 1 72.408  ? 57   GLU A CB  1 
ATOM   313  C  CG  . GLU A 1 39  ? 7.068   25.992 60.815 1 95.278  ? 57   GLU A CG  1 
ATOM   314  C  CD  . GLU A 1 39  ? 8.02    25.219 61.729 1 109.777 ? 57   GLU A CD  1 
ATOM   315  O  OE1 . GLU A 1 39  ? 9.13    25.759 61.964 1 110.696 ? 57   GLU A OE1 1 
ATOM   316  O  OE2 . GLU A 1 39  ? 7.69    24.095 62.194 1 97.853  ? 57   GLU A OE2 1 
ATOM   317  N  N   . ASN A 1 40  ? 3.506   26.309 58.951 1 47.759  ? 58   ASN A N   1 
ATOM   318  C  CA  . ASN A 1 40  ? 3.089   25.912 57.616 1 44.055  ? 58   ASN A CA  1 
ATOM   319  C  C   . ASN A 1 40  ? 2.558   27.118 56.83  1 41.936  ? 58   ASN A C   1 
ATOM   320  O  O   . ASN A 1 40  ? 2.673   27.154 55.602 1 37.45   ? 58   ASN A O   1 
ATOM   321  C  CB  . ASN A 1 40  ? 2.087   24.773 57.695 1 47.072  ? 58   ASN A CB  1 
ATOM   322  C  CG  . ASN A 1 40  ? 2.701   23.449 58.093 1 46.09   ? 58   ASN A CG  1 
ATOM   323  O  OD1 . ASN A 1 40  ? 3.914   23.278 58.053 1 56.424  ? 58   ASN A OD1 1 
ATOM   324  N  ND2 . ASN A 1 40  ? 1.879   22.468 58.423 1 50.782  ? 58   ASN A ND2 1 
ATOM   325  N  N   . GLU A 1 41  ? 1.965   28.095 57.535 1 38.22   ? 59   GLU A N   1 
ATOM   326  C  CA  . GLU A 1 41  ? 1.506   29.335 56.923 1 41.99   ? 59   GLU A CA  1 
ATOM   327  C  C   . GLU A 1 41  ? 2.723   30.038 56.314 1 41.697  ? 59   GLU A C   1 
ATOM   328  O  O   . GLU A 1 41  ? 2.746   30.297 55.107 1 35.807  ? 59   GLU A O   1 
ATOM   329  C  CB  . GLU A 1 41  ? 0.704   30.163 57.939 1 44.678  ? 59   GLU A CB  1 
ATOM   330  C  CG  . GLU A 1 41  ? 0.256   31.546 57.458 1 52.896  ? 59   GLU A CG  1 
ATOM   331  C  CD  . GLU A 1 41  ? -0.455  32.488 58.445 1 58.891  ? 59   GLU A CD  1 
ATOM   332  O  OE1 . GLU A 1 41  ? -0.698  32.147 59.622 1 63.05   ? 59   GLU A OE1 1 
ATOM   333  O  OE2 . GLU A 1 41  ? -0.791  33.618 58.019 1 72.514  ? 59   GLU A OE2 1 
ATOM   334  N  N   . LYS A 1 42  ? 3.761   30.279 57.138 1 46.532  ? 60   LYS A N   1 
ATOM   335  C  CA  . LYS A 1 42  ? 4.973   30.939 56.667 1 47.132  ? 60   LYS A CA  1 
ATOM   336  C  C   . LYS A 1 42  ? 5.567   30.145 55.51  1 44.309  ? 60   LYS A C   1 
ATOM   337  O  O   . LYS A 1 42  ? 5.916   30.749 54.513 1 50.417  ? 60   LYS A O   1 
ATOM   338  C  CB  . LYS A 1 42  ? 6.084   31.189 57.694 1 60.843  ? 60   LYS A CB  1 
ATOM   339  C  CG  . LYS A 1 42  ? 5.78    32.158 58.849 1 80.235  ? 60   LYS A CG  1 
ATOM   340  C  CD  . LYS A 1 42  ? 6.954   32.907 59.496 1 95.159  ? 60   LYS A CD  1 
ATOM   341  C  CE  . LYS A 1 42  ? 8.339   32.329 59.305 1 100.315 ? 60   LYS A CE  1 
ATOM   342  N  NZ  . LYS A 1 42  ? 8.442   30.909 59.651 1 106.74  ? 60   LYS A NZ  1 
ATOM   343  N  N   . LYS A 1 43  ? 5.641   28.811 55.59  1 41.763  ? 61   LYS A N   1 
ATOM   344  C  CA  . LYS A 1 43  ? 6.229   28.059 54.493 1 48.727  ? 61   LYS A CA  1 
ATOM   345  C  C   . LYS A 1 43  ? 5.434   28.326 53.218 1 45.043  ? 61   LYS A C   1 
ATOM   346  O  O   . LYS A 1 43  ? 6.028   28.573 52.181 1 45.857  ? 61   LYS A O   1 
ATOM   347  C  CB  . LYS A 1 43  ? 6.348   26.53  54.648 1 60.834  ? 61   LYS A CB  1 
ATOM   348  C  CG  . LYS A 1 43  ? 7.086   26.016 55.888 1 72.331  ? 61   LYS A CG  1 
ATOM   349  C  CD  . LYS A 1 43  ? 8.39    26.747 56.21  1 91.975  ? 61   LYS A CD  1 
ATOM   350  C  CE  . LYS A 1 43  ? 8.844   26.686 57.649 1 96.624  ? 61   LYS A CE  1 
ATOM   351  N  NZ  . LYS A 1 43  ? 9.476   25.416 58.022 1 92.33   ? 61   LYS A NZ  1 
ATOM   352  N  N   . LYS A 1 44  ? 4.098   28.237 53.286 1 41.292  ? 62   LYS A N   1 
ATOM   353  C  CA  . LYS A 1 44  ? 3.265   28.377 52.099 1 42.41   ? 62   LYS A CA  1 
ATOM   354  C  C   . LYS A 1 44  ? 3.462   29.752 51.461 1 35.357  ? 62   LYS A C   1 
ATOM   355  O  O   . LYS A 1 44  ? 3.598   29.873 50.244 1 30.986  ? 62   LYS A O   1 
ATOM   356  C  CB  . LYS A 1 44  ? 1.803   28.148 52.504 1 48.941  ? 62   LYS A CB  1 
ATOM   357  C  CG  . LYS A 1 44  ? 0.667   28.643 51.603 1 50.932  ? 62   LYS A CG  1 
ATOM   358  C  CD  . LYS A 1 44  ? -0.647  28.605 52.389 1 56.778  ? 62   LYS A CD  1 
ATOM   359  C  CE  . LYS A 1 44  ? -1.829  29.293 51.77  1 61.255  ? 62   LYS A CE  1 
ATOM   360  N  NZ  . LYS A 1 44  ? -2.028  28.974 50.352 1 57.496  ? 62   LYS A NZ  1 
ATOM   361  N  N   . ASN A 1 45  ? 3.441   30.792 52.292 1 31.175  ? 63   ASN A N   1 
ATOM   362  C  CA  . ASN A 1 45  ? 3.514   32.159 51.803 1 36.961  ? 63   ASN A CA  1 
ATOM   363  C  C   . ASN A 1 45  ? 4.911   32.506 51.26  1 41.963  ? 63   ASN A C   1 
ATOM   364  O  O   . ASN A 1 45  ? 5.028   33.261 50.292 1 42.798  ? 63   ASN A O   1 
ATOM   365  C  CB  . ASN A 1 45  ? 3.005   33.1   52.886 1 37.514  ? 63   ASN A CB  1 
ATOM   366  C  CG  . ASN A 1 45  ? 1.506   32.995 53.088 1 37.253  ? 63   ASN A CG  1 
ATOM   367  O  OD1 . ASN A 1 45  ? 0.795   32.442 52.238 1 35.252  ? 63   ASN A OD1 1 
ATOM   368  N  ND2 . ASN A 1 45  ? 1.004   33.542 54.19  1 36.615  ? 63   ASN A ND2 1 
ATOM   369  N  N   . GLU A 1 46  ? 5.977   31.925 51.835 1 46.19   ? 64   GLU A N   1 
ATOM   370  C  CA  . GLU A 1 46  ? 7.334   32.215 51.393 1 47.388  ? 64   GLU A CA  1 
ATOM   371  C  C   . GLU A 1 46  ? 7.559   31.587 50.018 1 44.377  ? 64   GLU A C   1 
ATOM   372  O  O   . GLU A 1 46  ? 8.108   32.243 49.135 1 46.247  ? 64   GLU A O   1 
ATOM   373  C  CB  . GLU A 1 46  ? 8.399   31.824 52.422 1 57.089  ? 64   GLU A CB  1 
ATOM   374  C  CG  . GLU A 1 46  ? 8.37    32.717 53.67  1 74.169  ? 64   GLU A CG  1 
ATOM   375  C  CD  . GLU A 1 46  ? 9.361   32.375 54.795 1 93.605  ? 64   GLU A CD  1 
ATOM   376  O  OE1 . GLU A 1 46  ? 9.485   33.163 55.779 1 80.434  ? 64   GLU A OE1 1 
ATOM   377  O  OE2 . GLU A 1 46  ? 10.015  31.3   54.701 1 103.298 ? 64   GLU A OE2 1 
ATOM   378  N  N   . ILE A 1 47  ? 7.111   30.341 49.819 1 39.109  ? 65   ILE A N   1 
ATOM   379  C  CA  . ILE A 1 47  ? 7.246   29.688 48.523 1 41.81   ? 65   ILE A CA  1 
ATOM   380  C  C   . ILE A 1 47  ? 6.485   30.482 47.454 1 42.508  ? 65   ILE A C   1 
ATOM   381  O  O   . ILE A 1 47  ? 6.967   30.626 46.323 1 41.105  ? 65   ILE A O   1 
ATOM   382  C  CB  . ILE A 1 47  ? 6.746   28.231 48.55  1 45.858  ? 65   ILE A CB  1 
ATOM   383  C  CG1 . ILE A 1 47  ? 7.361   27.399 49.689 1 61.367  ? 65   ILE A CG1 1 
ATOM   384  C  CG2 . ILE A 1 47  ? 6.969   27.578 47.193 1 44.936  ? 65   ILE A CG2 1 
ATOM   385  C  CD1 . ILE A 1 47  ? 8.878   27.434 49.767 1 68.973  ? 65   ILE A CD1 1 
ATOM   386  N  N   . SER A 1 48  ? 5.261   30.924 47.799 1 37.943  ? 66   SER A N   1 
ATOM   387  C  CA  . SER A 1 48  ? 4.413   31.679 46.891 1 37.854  ? 66   SER A CA  1 
ATOM   388  C  C   . SER A 1 48  ? 5.098   32.968 46.458 1 34.443  ? 66   SER A C   1 
ATOM   389  O  O   . SER A 1 48  ? 5.082   33.317 45.275 1 32.545  ? 66   SER A O   1 
ATOM   390  C  CB  . SER A 1 48  ? 3.084   31.98  47.512 1 37.979  ? 66   SER A CB  1 
ATOM   391  O  OG  . SER A 1 48  ? 2.253   30.863 47.3   1 41.583  ? 66   SER A OG  1 
ATOM   392  N  N   . ALA A 1 49  ? 5.661   33.667 47.446 1 31.733  ? 67   ALA A N   1 
ATOM   393  C  CA  . ALA A 1 49  ? 6.445   34.871 47.191 1 34.374  ? 67   ALA A CA  1 
ATOM   394  C  C   . ALA A 1 49  ? 7.58    34.612 46.199 1 36.268  ? 67   ALA A C   1 
ATOM   395  O  O   . ALA A 1 49  ? 7.836   35.451 45.356 1 39.754  ? 67   ALA A O   1 
ATOM   396  C  CB  . ALA A 1 49  ? 6.945   35.44  48.502 1 31.753  ? 67   ALA A CB  1 
ATOM   397  N  N   . GLU A 1 50  ? 8.234   33.445 46.266 1 39.451  ? 68   GLU A N   1 
ATOM   398  C  CA  . GLU A 1 50  ? 9.338   33.146 45.374 1 43.775  ? 68   GLU A CA  1 
ATOM   399  C  C   . GLU A 1 50  ? 8.83    32.807 43.985 1 39.684  ? 68   GLU A C   1 
ATOM   400  O  O   . GLU A 1 50  ? 9.473   33.139 42.997 1 42.008  ? 68   GLU A O   1 
ATOM   401  C  CB  . GLU A 1 50  ? 10.183  31.954 45.827 1 56.451  ? 68   GLU A CB  1 
ATOM   402  C  CG  . GLU A 1 50  ? 11.203  32.331 46.894 1 70.525  ? 68   GLU A CG  1 
ATOM   403  C  CD  . GLU A 1 50  ? 11.577  31.115 47.713 1 88.974  ? 68   GLU A CD  1 
ATOM   404  O  OE1 . GLU A 1 50  ? 11.961  30.121 47.04  1 86.118  ? 68   GLU A OE1 1 
ATOM   405  O  OE2 . GLU A 1 50  ? 11.46   31.149 48.975 1 92.977  ? 68   GLU A OE2 1 
ATOM   406  N  N   . LEU A 1 51  ? 7.722   32.074 43.912 1 35.315  ? 69   LEU A N   1 
ATOM   407  C  CA  . LEU A 1 51  ? 7.139   31.776 42.623 1 35.819  ? 69   LEU A CA  1 
ATOM   408  C  C   . LEU A 1 51  ? 6.629   33.071 41.985 1 35.928  ? 69   LEU A C   1 
ATOM   409  O  O   . LEU A 1 51  ? 6.823   33.261 40.792 1 34.242  ? 69   LEU A O   1 
ATOM   410  C  CB  . LEU A 1 51  ? 6.039   30.724 42.748 1 39.302  ? 69   LEU A CB  1 
ATOM   411  C  CG  . LEU A 1 51  ? 5.318   30.408 41.436 1 41.668  ? 69   LEU A CG  1 
ATOM   412  C  CD1 . LEU A 1 51  ? 6.23    29.717 40.459 1 41.485  ? 69   LEU A CD1 1 
ATOM   413  C  CD2 . LEU A 1 51  ? 4.056   29.592 41.698 1 49.164  ? 69   LEU A CD2 1 
ATOM   414  N  N   . ALA A 1 52  ? 5.996   33.96  42.769 1 35.952  ? 70   ALA A N   1 
ATOM   415  C  CA  . ALA A 1 52  ? 5.571   35.269 42.277 1 37.187  ? 70   ALA A CA  1 
ATOM   416  C  C   . ALA A 1 52  ? 6.739   36.012 41.622 1 42.592  ? 70   ALA A C   1 
ATOM   417  O  O   . ALA A 1 52  ? 6.612   36.494 40.488 1 38.744  ? 70   ALA A O   1 
ATOM   418  C  CB  . ALA A 1 52  ? 4.998   36.104 43.405 1 35.053  ? 70   ALA A CB  1 
ATOM   419  N  N   . LYS A 1 53  ? 7.882   36.079 42.332 1 38.831  ? 71   LYS A N   1 
ATOM   420  C  CA  . LYS A 1 53  ? 9.053   36.782 41.827 1 43.243  ? 71   LYS A CA  1 
ATOM   421  C  C   . LYS A 1 53  ? 9.521   36.203 40.49  1 40.137  ? 71   LYS A C   1 
ATOM   422  O  O   . LYS A 1 53  ? 9.85    36.944 39.577 1 40.91   ? 71   LYS A O   1 
ATOM   423  C  CB  . LYS A 1 53  ? 10.227  36.79  42.807 1 52.521  ? 71   LYS A CB  1 
ATOM   424  C  CG  . LYS A 1 53  ? 11.348  37.699 42.324 1 67.023  ? 71   LYS A CG  1 
ATOM   425  C  CD  . LYS A 1 53  ? 12.655  37.567 43.093 1 83.947  ? 71   LYS A CD  1 
ATOM   426  C  CE  . LYS A 1 53  ? 12.479  37.923 44.531 1 91.892  ? 71   LYS A CE  1 
ATOM   427  N  NZ  . LYS A 1 53  ? 13.729  38.501 45.023 1 94.509  ? 71   LYS A NZ  1 
ATOM   428  N  N   . PHE A 1 54  ? 9.536   34.877 40.359 1 37.131  ? 72   PHE A N   1 
ATOM   429  C  CA  . PHE A 1 54  ? 9.938   34.234 39.119 1 34.83   ? 72   PHE A CA  1 
ATOM   430  C  C   . PHE A 1 54  ? 8.939   34.509 37.991 1 33.885  ? 72   PHE A C   1 
ATOM   431  O  O   . PHE A 1 54  ? 9.337   34.642 36.845 1 34.917  ? 72   PHE A O   1 
ATOM   432  C  CB  . PHE A 1 54  ? 10.144  32.736 39.419 1 37.337  ? 72   PHE A CB  1 
ATOM   433  C  CG  . PHE A 1 54  ? 10.443  31.917 38.175 1 35.1    ? 72   PHE A CG  1 
ATOM   434  C  CD1 . PHE A 1 54  ? 11.726  31.892 37.635 1 40.266  ? 72   PHE A CD1 1 
ATOM   435  C  CD2 . PHE A 1 54  ? 9.429   31.275 37.488 1 33.696  ? 72   PHE A CD2 1 
ATOM   436  C  CE1 . PHE A 1 54  ? 11.99   31.211 36.45  1 36.138  ? 72   PHE A CE1 1 
ATOM   437  C  CE2 . PHE A 1 54  ? 9.698   30.602 36.305 1 34.62   ? 72   PHE A CE2 1 
ATOM   438  C  CZ  . PHE A 1 54  ? 10.979  30.56  35.796 1 34.994  ? 72   PHE A CZ  1 
ATOM   439  N  N   . MET A 1 55  ? 7.64    34.535 38.297 1 36.683  ? 73   MET A N   1 
ATOM   440  C  CA  . MET A 1 55  ? 6.61    34.861 37.32  1 41.018  ? 73   MET A CA  1 
ATOM   441  C  C   . MET A 1 55  ? 6.848   36.251 36.71  1 39.206  ? 73   MET A C   1 
ATOM   442  O  O   . MET A 1 55  ? 6.714   36.439 35.496 1 35.078  ? 73   MET A O   1 
ATOM   443  C  CB  . MET A 1 55  ? 5.215   34.838 37.965 1 47.263  ? 73   MET A CB  1 
ATOM   444  C  CG  . MET A 1 55  ? 4.655   33.472 38.344 1 50.374  ? 73   MET A CG  1 
ATOM   445  S  SD  . MET A 1 55  ? 4.971   32.302 37.017 1 68.956  ? 73   MET A SD  1 
ATOM   446  C  CE  . MET A 1 55  ? 4.15    33.013 35.577 1 73.674  ? 73   MET A CE  1 
ATOM   447  N  N   . LYS A 1 56  ? 7.191   37.234 37.549 1 35.866  ? 74   LYS A N   1 
ATOM   448  C  CA  . LYS A 1 56  ? 7.534   38.566 37.07  1 40.463  ? 74   LYS A CA  1 
ATOM   449  C  C   . LYS A 1 56  ? 8.711   38.539 36.095 1 44.249  ? 74   LYS A C   1 
ATOM   450  O  O   . LYS A 1 56  ? 8.648   39.206 35.062 1 47.318  ? 74   LYS A O   1 
ATOM   451  C  CB  . LYS A 1 56  ? 7.983   39.516 38.176 1 44.655  ? 74   LYS A CB  1 
ATOM   452  C  CG  . LYS A 1 56  ? 6.928   40.257 38.925 1 49.4    ? 74   LYS A CG  1 
ATOM   453  C  CD  . LYS A 1 56  ? 7.469   41.616 39.343 1 52.615  ? 74   LYS A CD  1 
ATOM   454  C  CE  . LYS A 1 56  ? 6.599   42.272 40.344 1 57.421  ? 74   LYS A CE  1 
ATOM   455  N  NZ  . LYS A 1 56  ? 6.444   41.437 41.54  1 54.716  ? 74   LYS A NZ  1 
ATOM   456  N  N   . GLU A 1 57  ? 9.795   37.805 36.42  1 44.28   ? 75   GLU A N   1 
ATOM   457  C  CA  . GLU A 1 57  ? 10.916  37.674 35.496 1 46.401  ? 75   GLU A CA  1 
ATOM   458  C  C   . GLU A 1 57  ? 10.395  37.117 34.172 1 41.82   ? 75   GLU A C   1 
ATOM   459  O  O   . GLU A 1 57  ? 10.75   37.579 33.092 1 45.041  ? 75   GLU A O   1 
ATOM   460  C  CB  . GLU A 1 57  ? 12.068  36.833 36.045 1 56.274  ? 75   GLU A CB  1 
ATOM   461  C  CG  . GLU A 1 57  ? 12.782  37.465 37.243 1 77.944  ? 75   GLU A CG  1 
ATOM   462  C  CD  . GLU A 1 57  ? 13.786  36.589 38.015 1 93.838  ? 75   GLU A CD  1 
ATOM   463  O  OE1 . GLU A 1 57  ? 14.681  35.996 37.357 1 91.375  ? 75   GLU A OE1 1 
ATOM   464  O  OE2 . GLU A 1 57  ? 13.71   36.511 39.277 1 83.602  ? 75   GLU A OE2 1 
ATOM   465  N  N   . VAL A 1 58  ? 9.497   36.145 34.25  1 37.046  ? 76   VAL A N   1 
ATOM   466  C  CA  . VAL A 1 58  ? 9.026   35.496 33.044 1 42.489  ? 76   VAL A CA  1 
ATOM   467  C  C   . VAL A 1 58  ? 8.221   36.492 32.209 1 44.997  ? 76   VAL A C   1 
ATOM   468  O  O   . VAL A 1 58  ? 8.421   36.56  31.004 1 47.07   ? 76   VAL A O   1 
ATOM   469  C  CB  . VAL A 1 58  ? 8.199   34.229 33.347 1 42.642  ? 76   VAL A CB  1 
ATOM   470  C  CG1 . VAL A 1 58  ? 7.464   33.734 32.102 1 43.03   ? 76   VAL A CG1 1 
ATOM   471  C  CG2 . VAL A 1 58  ? 9.047   33.123 33.97  1 40.835  ? 76   VAL A CG2 1 
ATOM   472  N  N   . ALA A 1 59  ? 7.276   37.207 32.835 1 43.805  ? 77   ALA A N   1 
ATOM   473  C  CA  . ALA A 1 59  ? 6.475   38.205 32.134 1 49.799  ? 77   ALA A CA  1 
ATOM   474  C  C   . ALA A 1 59  ? 7.378   39.178 31.366 1 47.483  ? 77   ALA A C   1 
ATOM   475  O  O   . ALA A 1 59  ? 7.176   39.438 30.176 1 47.442  ? 77   ALA A O   1 
ATOM   476  C  CB  . ALA A 1 59  ? 5.577   38.948 33.119 1 45.626  ? 77   ALA A CB  1 
ATOM   477  N  N   . SER A 1 60  ? 8.385   39.699 32.065 1 45.22   ? 78   SER A N   1 
ATOM   478  C  CA  . SER A 1 60  ? 9.351   40.62  31.494 1 50.275  ? 78   SER A CA  1 
ATOM   479  C  C   . SER A 1 60  ? 10.144  39.969 30.359 1 57.003  ? 78   SER A C   1 
ATOM   480  O  O   . SER A 1 60  ? 10.451  40.632 29.378 1 70.301  ? 78   SER A O   1 
ATOM   481  C  CB  . SER A 1 60  ? 10.24   41.161 32.576 1 51.179  ? 78   SER A CB  1 
ATOM   482  O  OG  . SER A 1 60  ? 11.513  41.481 32.058 1 56.161  ? 78   SER A OG  1 
ATOM   483  N  N   . ASP A 1 61  ? 10.452  38.671 30.443 1 58.058  ? 79   ASP A N   1 
ATOM   484  C  CA  . ASP A 1 61  ? 11.137  38.011 29.339 1 56.727  ? 79   ASP A CA  1 
ATOM   485  C  C   . ASP A 1 61  ? 10.246  37.761 28.123 1 55.774  ? 79   ASP A C   1 
ATOM   486  O  O   . ASP A 1 61  ? 10.764  37.529 27.041 1 53.742  ? 79   ASP A O   1 
ATOM   487  C  CB  . ASP A 1 61  ? 11.738  36.687 29.761 1 65.026  ? 79   ASP A CB  1 
ATOM   488  C  CG  . ASP A 1 61  ? 12.975  36.807 30.629 1 70.682  ? 79   ASP A CG  1 
ATOM   489  O  OD1 . ASP A 1 61  ? 13.343  37.955 30.969 1 80.297  ? 79   ASP A OD1 1 
ATOM   490  O  OD2 . ASP A 1 61  ? 13.552  35.756 30.938 1 69.143  ? 79   ASP A OD2 1 
ATOM   491  N  N   . THR A 1 62  ? 8.916   37.768 28.265 1 56.241  ? 80   THR A N   1 
ATOM   492  C  CA  . THR A 1 62  ? 8.073   37.612 27.091 1 60.021  ? 80   THR A CA  1 
ATOM   493  C  C   . THR A 1 62  ? 8.255   38.793 26.127 1 62.771  ? 80   THR A C   1 
ATOM   494  O  O   . THR A 1 62  ? 7.989   38.629 24.933 1 60.867  ? 80   THR A O   1 
ATOM   495  C  CB  . THR A 1 62  ? 6.6     37.429 27.465 1 66.059  ? 80   THR A CB  1 
ATOM   496  O  OG1 . THR A 1 62  ? 6.102   38.668 27.975 1 59.496  ? 80   THR A OG1 1 
ATOM   497  C  CG2 . THR A 1 62  ? 6.395   36.242 28.393 1 64.663  ? 80   THR A CG2 1 
ATOM   498  N  N   . THR A 1 63  ? 8.698   39.972 26.621 1 57.367  ? 81   THR A N   1 
ATOM   499  C  CA  . THR A 1 63  ? 8.796   41.169 25.785 1 62.332  ? 81   THR A CA  1 
ATOM   500  C  C   . THR A 1 63  ? 9.988   41.067 24.825 1 63.598  ? 81   THR A C   1 
ATOM   501  O  O   . THR A 1 63  ? 10.02   41.738 23.799 1 64.583  ? 81   THR A O   1 
ATOM   502  C  CB  . THR A 1 63  ? 8.876   42.456 26.611 1 60.847  ? 81   THR A CB  1 
ATOM   503  O  OG1 . THR A 1 63  ? 10.198  42.487 27.142 1 59.759  ? 81   THR A OG1 1 
ATOM   504  C  CG2 . THR A 1 63  ? 7.786   42.575 27.666 1 54.797  ? 81   THR A CG2 1 
ATOM   505  N  N   . LYS A 1 64  ? 10.942  40.19  25.135 1 56.135  ? 82   LYS A N   1 
ATOM   506  C  CA  . LYS A 1 64  ? 12.098  39.958 24.294 1 52.51   ? 82   LYS A CA  1 
ATOM   507  C  C   . LYS A 1 64  ? 11.734  39.166 23.044 1 50.94   ? 82   LYS A C   1 
ATOM   508  O  O   . LYS A 1 64  ? 12.562  39.053 22.154 1 53.527  ? 82   LYS A O   1 
ATOM   509  C  CB  . LYS A 1 64  ? 13.15   39.267 25.162 1 62.155  ? 82   LYS A CB  1 
ATOM   510  C  CG  . LYS A 1 64  ? 13.456  40.126 26.407 1 84.298  ? 82   LYS A CG  1 
ATOM   511  C  CD  . LYS A 1 64  ? 14.652  39.711 27.259 1 103.122 ? 82   LYS A CD  1 
ATOM   512  C  CE  . LYS A 1 64  ? 14.978  40.717 28.332 1 107.447 ? 82   LYS A CE  1 
ATOM   513  N  NZ  . LYS A 1 64  ? 16.156  40.29  29.094 1 107.879 ? 82   LYS A NZ  1 
ATOM   514  N  N   . PHE A 1 65  ? 10.513  38.628 22.96  1 46.958  ? 83   PHE A N   1 
ATOM   515  C  CA  . PHE A 1 65  ? 10.074  37.901 21.776 1 46.163  ? 83   PHE A CA  1 
ATOM   516  C  C   . PHE A 1 65  ? 8.959   38.686 21.092 1 46.863  ? 83   PHE A C   1 
ATOM   517  O  O   . PHE A 1 65  ? 8.064   39.175 21.776 1 49.161  ? 83   PHE A O   1 
ATOM   518  C  CB  . PHE A 1 65  ? 9.503   36.507 22.097 1 44.556  ? 83   PHE A CB  1 
ATOM   519  C  CG  . PHE A 1 65  ? 10.479  35.521 22.722 1 43.066  ? 83   PHE A CG  1 
ATOM   520  C  CD1 . PHE A 1 65  ? 10.687  35.498 24.097 1 46.045  ? 83   PHE A CD1 1 
ATOM   521  C  CD2 . PHE A 1 65  ? 11.218  34.644 21.936 1 48.001  ? 83   PHE A CD2 1 
ATOM   522  C  CE1 . PHE A 1 65  ? 11.597  34.617 24.666 1 44.81   ? 83   PHE A CE1 1 
ATOM   523  C  CE2 . PHE A 1 65  ? 12.135  33.768 22.511 1 47.262  ? 83   PHE A CE2 1 
ATOM   524  C  CZ  . PHE A 1 65  ? 12.314  33.752 23.873 1 46.334  ? 83   PHE A CZ  1 
ATOM   525  N  N   . GLN A 1 66  ? 8.986   38.726 19.747 1 43.733  ? 84   GLN A N   1 
ATOM   526  C  CA  . GLN A 1 66  ? 7.97    39.386 18.934 1 42.827  ? 84   GLN A CA  1 
ATOM   527  C  C   . GLN A 1 66  ? 6.717   38.532 18.81  1 35.948  ? 84   GLN A C   1 
ATOM   528  O  O   . GLN A 1 66  ? 6.227   38.317 17.704 1 37.011  ? 84   GLN A O   1 
ATOM   529  C  CB  . GLN A 1 66  ? 8.464   39.639 17.506 1 50.987  ? 84   GLN A CB  1 
ATOM   530  C  CG  . GLN A 1 66  ? 9.556   40.695 17.417 1 54.698  ? 84   GLN A CG  1 
ATOM   531  C  CD  . GLN A 1 66  ? 9.172   41.906 18.232 1 59.68   ? 84   GLN A CD  1 
ATOM   532  O  OE1 . GLN A 1 66  ? 8.108   42.504 18.025 1 62.428  ? 84   GLN A OE1 1 
ATOM   533  N  NE2 . GLN A 1 66  ? 9.973   42.205 19.241 1 60.334  ? 84   GLN A NE2 1 
ATOM   534  N  N   . TRP A 1 67  ? 6.174   38.069 19.942 1 38.657  ? 85   TRP A N   1 
ATOM   535  C  CA  . TRP A 1 67  ? 5.29    36.91  19.905 1 36.929  ? 85   TRP A CA  1 
ATOM   536  C  C   . TRP A 1 67  ? 3.97    37.232 19.209 1 38.217  ? 85   TRP A C   1 
ATOM   537  O  O   . TRP A 1 67  ? 3.391   36.351 18.577 1 39.074  ? 85   TRP A O   1 
ATOM   538  C  CB  . TRP A 1 67  ? 5.098   36.298 21.306 1 38.26   ? 85   TRP A CB  1 
ATOM   539  C  CG  . TRP A 1 67  ? 4.403   37.128 22.361 1 35.426  ? 85   TRP A CG  1 
ATOM   540  C  CD1 . TRP A 1 67  ? 4.993   37.766 23.414 1 34.701  ? 85   TRP A CD1 1 
ATOM   541  C  CD2 . TRP A 1 67  ? 2.98    37.298 22.547 1 32.501  ? 85   TRP A CD2 1 
ATOM   542  N  NE1 . TRP A 1 67  ? 4.052   38.38  24.194 1 35.041  ? 85   TRP A NE1 1 
ATOM   543  C  CE2 . TRP A 1 67  ? 2.81    38.09  23.7   1 35.646  ? 85   TRP A CE2 1 
ATOM   544  C  CE3 . TRP A 1 67  ? 1.841   36.866 21.86  1 32.764  ? 85   TRP A CE3 1 
ATOM   545  C  CZ2 . TRP A 1 67  ? 1.549   38.464 24.155 1 41.111  ? 85   TRP A CZ2 1 
ATOM   546  C  CZ3 . TRP A 1 67  ? 0.594   37.225 22.316 1 34.869  ? 85   TRP A CZ3 1 
ATOM   547  C  CH2 . TRP A 1 67  ? 0.45    38.01  23.456 1 36.841  ? 85   TRP A CH2 1 
ATOM   548  N  N   . ARG A 1 68  ? 3.511   38.495 19.265 1 36.08   ? 86   ARG A N   1 
ATOM   549  C  CA  . ARG A 1 68  ? 2.26    38.86  18.608 1 36.891  ? 86   ARG A CA  1 
ATOM   550  C  C   . ARG A 1 68  ? 2.413   38.828 17.09  1 35.156  ? 86   ARG A C   1 
ATOM   551  O  O   . ARG A 1 68  ? 1.404   38.761 16.402 1 39.401  ? 86   ARG A O   1 
ATOM   552  C  CB  . ARG A 1 68  ? 1.725   40.223 19.053 1 39.644  ? 86   ARG A CB  1 
ATOM   553  C  CG  . ARG A 1 68  ? 1.443   40.331 20.547 1 39.225  ? 86   ARG A CG  1 
ATOM   554  C  CD  . ARG A 1 68  ? 0.972   41.713 20.928 1 38.229  ? 86   ARG A CD  1 
ATOM   555  N  NE  . ARG A 1 68  ? 0.54    41.797 22.325 1 37.598  ? 86   ARG A NE  1 
ATOM   556  C  CZ  . ARG A 1 68  ? 1.349   41.965 23.356 1 37.203  ? 86   ARG A CZ  1 
ATOM   557  N  NH1 . ARG A 1 68  ? 2.634   42.1   23.138 1 39.552  ? 86   ARG A NH1 1 
ATOM   558  N  NH2 . ARG A 1 68  ? 0.883   42.015 24.592 1 39.535  ? 86   ARG A NH2 1 
ATOM   559  N  N   . SER A 1 69  ? 3.658   38.772 16.587 1 34.482  ? 87   SER A N   1 
ATOM   560  C  CA  . SER A 1 69  ? 3.928   38.71  15.151 1 38.988  ? 87   SER A CA  1 
ATOM   561  C  C   . SER A 1 69  ? 3.929   37.29  14.588 1 38.231  ? 87   SER A C   1 
ATOM   562  O  O   . SER A 1 69  ? 4.038   37.129 13.384 1 41.399  ? 87   SER A O   1 
ATOM   563  C  CB  . SER A 1 69  ? 5.258   39.348 14.832 1 39.582  ? 87   SER A CB  1 
ATOM   564  O  OG  . SER A 1 69  ? 5.253   40.741 15.116 1 38.033  ? 87   SER A OG  1 
ATOM   565  N  N   . TYR A 1 70  ? 3.829   36.261 15.439 1 40.254  ? 88   TYR A N   1 
ATOM   566  C  CA  . TYR A 1 70  ? 4.09    34.894 15.013 1 34.445  ? 88   TYR A CA  1 
ATOM   567  C  C   . TYR A 1 70  ? 2.908   34.315 14.247 1 36.261  ? 88   TYR A C   1 
ATOM   568  O  O   . TYR A 1 70  ? 1.772   34.765 14.421 1 39.607  ? 88   TYR A O   1 
ATOM   569  C  CB  . TYR A 1 70  ? 4.396   33.999 16.214 1 34.254  ? 88   TYR A CB  1 
ATOM   570  C  CG  . TYR A 1 70  ? 5.696   34.264 16.961 1 32.169  ? 88   TYR A CG  1 
ATOM   571  C  CD1 . TYR A 1 70  ? 6.752   34.997 16.428 1 34.035  ? 88   TYR A CD1 1 
ATOM   572  C  CD2 . TYR A 1 70  ? 5.861   33.746 18.236 1 36.122  ? 88   TYR A CD2 1 
ATOM   573  C  CE1 . TYR A 1 70  ? 7.907   35.242 17.161 1 34.116  ? 88   TYR A CE1 1 
ATOM   574  C  CE2 . TYR A 1 70  ? 7.004   33.978 18.979 1 31.7    ? 88   TYR A CE2 1 
ATOM   575  C  CZ  . TYR A 1 70  ? 8.03    34.724 18.441 1 33.416  ? 88   TYR A CZ  1 
ATOM   576  O  OH  . TYR A 1 70  ? 9.137   34.851 19.227 1 39.689  ? 88   TYR A OH  1 
ATOM   577  N  N   . GLN A 1 71  ? 3.212   33.283 13.433 1 38.416  ? 89   GLN A N   1 
ATOM   578  C  CA  . GLN A 1 71  ? 2.251   32.536 12.625 1 44.756  ? 89   GLN A CA  1 
ATOM   579  C  C   . GLN A 1 71  ? 1.395   31.615 13.497 1 43.106  ? 89   GLN A C   1 
ATOM   580  O  O   . GLN A 1 71  ? 0.209   31.474 13.236 1 44.331  ? 89   GLN A O   1 
ATOM   581  C  CB  . GLN A 1 71  ? 2.928   31.673 11.548 1 55.009  ? 89   GLN A CB  1 
ATOM   582  C  CG  . GLN A 1 71  ? 3.722   32.461 10.502 1 70.611  ? 89   GLN A CG  1 
ATOM   583  C  CD  . GLN A 1 71  ? 2.84    33.22  9.524  1 78.023  ? 89   GLN A CD  1 
ATOM   584  O  OE1 . GLN A 1 71  ? 2.068   32.617 8.762  1 68.378  ? 89   GLN A OE1 1 
ATOM   585  N  NE2 . GLN A 1 71  ? 2.914   34.55  9.56   1 69.57   ? 89   GLN A NE2 1 
ATOM   586  N  N   . SER A 1 72  ? 1.998   30.997 14.525 1 43.826  ? 90   SER A N   1 
ATOM   587  C  CA  . SER A 1 72  ? 1.381   29.894 15.245 1 44.144  ? 90   SER A CA  1 
ATOM   588  C  C   . SER A 1 72  ? 0.424   30.415 16.314 1 39.967  ? 90   SER A C   1 
ATOM   589  O  O   . SER A 1 72  ? 0.862   30.979 17.321 1 36.444  ? 90   SER A O   1 
ATOM   590  C  CB  . SER A 1 72  ? 2.432   28.98  15.869 1 43.459  ? 90   SER A CB  1 
ATOM   591  O  OG  . SER A 1 72  ? 1.87    28.141 16.878 1 42.826  ? 90   SER A OG  1 
ATOM   592  N  N   . GLU A 1 73  ? -0.869  30.128 16.121 1 40.883  ? 91   GLU A N   1 
ATOM   593  C  CA  . GLU A 1 73  ? -1.892  30.447 17.11  1 44.586  ? 91   GLU A CA  1 
ATOM   594  C  C   . GLU A 1 73  ? -1.522  29.86  18.467 1 41.563  ? 91   GLU A C   1 
ATOM   595  O  O   . GLU A 1 73  ? -1.789  30.479 19.498 1 40.906  ? 91   GLU A O   1 
ATOM   596  C  CB  . GLU A 1 73  ? -3.292  29.943 16.75  1 50.651  ? 91   GLU A CB  1 
ATOM   597  C  CG  . GLU A 1 73  ? -3.945  30.703 15.595 1 66.248  ? 91   GLU A CG  1 
ATOM   598  C  CD  . GLU A 1 73  ? -4.23   32.189 15.817 1 82.296  ? 91   GLU A CD  1 
ATOM   599  O  OE1 . GLU A 1 73  ? -4.533  32.839 14.796 1 100.516 ? 91   GLU A OE1 1 
ATOM   600  O  OE2 . GLU A 1 73  ? -4.16   32.724 16.957 1 83.957  ? 91   GLU A OE2 1 
ATOM   601  N  N   . ASP A 1 74  ? -0.881  28.684 18.451 1 37.912  ? 92   ASP A N   1 
ATOM   602  C  CA  . ASP A 1 74  ? -0.581  27.952 19.668 1 36.839  ? 92   ASP A CA  1 
ATOM   603  C  C   . ASP A 1 74  ? 0.522   28.645 20.462 1 36.943  ? 92   ASP A C   1 
ATOM   604  O  O   . ASP A 1 74  ? 0.438   28.739 21.685 1 43.015  ? 92   ASP A O   1 
ATOM   605  C  CB  . ASP A 1 74  ? -0.239  26.509 19.338 1 40.326  ? 92   ASP A CB  1 
ATOM   606  C  CG  . ASP A 1 74  ? 0.002   25.64  20.554 1 46.629  ? 92   ASP A CG  1 
ATOM   607  O  OD1 . ASP A 1 74  ? -0.907  25.56  21.405 1 61.58   ? 92   ASP A OD1 1 
ATOM   608  O  OD2 . ASP A 1 74  ? 1.097   25.08  20.643 1 54.84   ? 92   ASP A OD2 1 
ATOM   609  N  N   . LEU A 1 75  ? 1.566   29.13  19.778 1 37.716  ? 93   LEU A N   1 
ATOM   610  C  CA  . LEU A 1 75  ? 2.64    29.834 20.46  1 38.595  ? 93   LEU A CA  1 
ATOM   611  C  C   . LEU A 1 75  ? 2.098   31.114 21.075 1 35.341  ? 93   LEU A C   1 
ATOM   612  O  O   . LEU A 1 75  ? 2.402   31.429 22.232 1 32.307  ? 93   LEU A O   1 
ATOM   613  C  CB  . LEU A 1 75  ? 3.831   30.14  19.559 1 41.877  ? 93   LEU A CB  1 
ATOM   614  C  CG  . LEU A 1 75  ? 4.571   28.91  19.033 1 49.769  ? 93   LEU A CG  1 
ATOM   615  C  CD1 . LEU A 1 75  ? 5.86    29.361 18.368 1 50.534  ? 93   LEU A CD1 1 
ATOM   616  C  CD2 . LEU A 1 75  ? 4.832   27.898 20.135 1 49.073  ? 93   LEU A CD2 1 
ATOM   617  N  N   . LYS A 1 76  ? 1.276   31.831 20.308 1 36.235  ? 94   LYS A N   1 
ATOM   618  C  CA  . LYS A 1 76  ? 0.77    33.11  20.794 1 38.277  ? 94   LYS A CA  1 
ATOM   619  C  C   . LYS A 1 76  ? -0.115  32.874 22.017 1 34.87   ? 94   LYS A C   1 
ATOM   620  O  O   . LYS A 1 76  ? -0.054  33.63  22.974 1 36.035  ? 94   LYS A O   1 
ATOM   621  C  CB  . LYS A 1 76  ? 0.049   33.877 19.684 1 39.427  ? 94   LYS A CB  1 
ATOM   622  C  CG  . LYS A 1 76  ? 0.924   34.22  18.494 1 38.096  ? 94   LYS A CG  1 
ATOM   623  C  CD  . LYS A 1 76  ? 0.187   35.03  17.443 1 42.85   ? 94   LYS A CD  1 
ATOM   624  C  CE  . LYS A 1 76  ? -0.624  34.155 16.57  1 47.89   ? 94   LYS A CE  1 
ATOM   625  N  NZ  . LYS A 1 76  ? -1.449  34.929 15.647 1 52.049  ? 94   LYS A NZ  1 
ATOM   626  N  N   . ARG A 1 77  ? -0.891  31.791 22.014 1 31.575  ? 95   ARG A N   1 
ATOM   627  C  CA  . ARG A 1 77  ? -1.782  31.538 23.125 1 32.683  ? 95   ARG A CA  1 
ATOM   628  C  C   . ARG A 1 77  ? -0.968  31.297 24.398 1 33.142  ? 95   ARG A C   1 
ATOM   629  O  O   . ARG A 1 77  ? -1.312  31.818 25.451 1 31.838  ? 95   ARG A O   1 
ATOM   630  C  CB  . ARG A 1 77  ? -2.789  30.456 22.735 1 32.083  ? 95   ARG A CB  1 
ATOM   631  C  CG  . ARG A 1 77  ? -3.76   30.149 23.86  1 34.037  ? 95   ARG A CG  1 
ATOM   632  C  CD  . ARG A 1 77  ? -4.719  29.093 23.374 1 35.497  ? 95   ARG A CD  1 
ATOM   633  N  NE  . ARG A 1 77  ? -5.671  28.788 24.439 1 37.275  ? 95   ARG A NE  1 
ATOM   634  C  CZ  . ARG A 1 77  ? -6.717  29.531 24.78  1 40.056  ? 95   ARG A CZ  1 
ATOM   635  N  NH1 . ARG A 1 77  ? -7.065  30.561 24.026 1 36.806  ? 95   ARG A NH1 1 
ATOM   636  N  NH2 . ARG A 1 77  ? -7.452  29.183 25.829 1 34.88   ? 95   ARG A NH2 1 
ATOM   637  N  N   . GLN A 1 78  ? 0.146   30.562 24.291 1 35.92   ? 96   GLN A N   1 
ATOM   638  C  CA  . GLN A 1 78  ? 0.953   30.224 25.461 1 34.599  ? 96   GLN A CA  1 
ATOM   639  C  C   . GLN A 1 78  ? 1.638   31.472 26.018 1 32.669  ? 96   GLN A C   1 
ATOM   640  O  O   . GLN A 1 78  ? 1.66    31.712 27.228 1 33.274  ? 96   GLN A O   1 
ATOM   641  C  CB  . GLN A 1 78  ? 1.981   29.146 25.113 1 33.485  ? 96   GLN A CB  1 
ATOM   642  C  CG  . GLN A 1 78  ? 1.389   27.765 24.883 1 36.442  ? 96   GLN A CG  1 
ATOM   643  C  CD  . GLN A 1 78  ? 2.436   26.73  24.509 1 38.246  ? 96   GLN A CD  1 
ATOM   644  O  OE1 . GLN A 1 78  ? 3.382   26.447 25.257 1 30.371  ? 96   GLN A OE1 1 
ATOM   645  N  NE2 . GLN A 1 78  ? 2.292   26.195 23.304 1 38.005  ? 96   GLN A NE2 1 
ATOM   646  N  N   . PHE A 1 79  ? 2.189   32.285 25.119 1 33.087  ? 97   PHE A N   1 
ATOM   647  C  CA  . PHE A 1 79  ? 2.809   33.544 25.512 1 35.358  ? 97   PHE A CA  1 
ATOM   648  C  C   . PHE A 1 79  ? 1.782   34.445 26.189 1 34.423  ? 97   PHE A C   1 
ATOM   649  O  O   . PHE A 1 79  ? 2.068   35.104 27.188 1 32.207  ? 97   PHE A O   1 
ATOM   650  C  CB  . PHE A 1 79  ? 3.456   34.216 24.293 1 35.755  ? 97   PHE A CB  1 
ATOM   651  C  CG  . PHE A 1 79  ? 4.914   33.847 24.065 1 32.123  ? 97   PHE A CG  1 
ATOM   652  C  CD1 . PHE A 1 79  ? 5.901   34.341 24.899 1 36.355  ? 97   PHE A CD1 1 
ATOM   653  C  CD2 . PHE A 1 79  ? 5.289   33.026 23.016 1 35.268  ? 97   PHE A CD2 1 
ATOM   654  C  CE1 . PHE A 1 79  ? 7.233   34.021 24.684 1 39.012  ? 97   PHE A CE1 1 
ATOM   655  C  CE2 . PHE A 1 79  ? 6.617   32.692 22.819 1 36.81   ? 97   PHE A CE2 1 
ATOM   656  C  CZ  . PHE A 1 79  ? 7.583   33.18  23.66  1 35.482  ? 97   PHE A CZ  1 
ATOM   657  N  N   . LYS A 1 80  ? 0.572   34.476 25.634 1 38.03   ? 98   LYS A N   1 
ATOM   658  C  CA  . LYS A 1 80  ? -0.465  35.317 26.204 1 40.167  ? 98   LYS A CA  1 
ATOM   659  C  C   . LYS A 1 80  ? -0.64   34.924 27.664 1 41.136  ? 98   LYS A C   1 
ATOM   660  O  O   . LYS A 1 80  ? -0.631  35.797 28.534 1 38.605  ? 98   LYS A O   1 
ATOM   661  C  CB  . LYS A 1 80  ? -1.778  35.208 25.429 1 44.081  ? 98   LYS A CB  1 
ATOM   662  C  CG  . LYS A 1 80  ? -2.444  36.552 25.357 1 55.43   ? 98   LYS A CG  1 
ATOM   663  C  CD  . LYS A 1 80  ? -3.739  36.618 24.566 1 62.767  ? 98   LYS A CD  1 
ATOM   664  C  CE  . LYS A 1 80  ? -4.626  37.579 25.275 1 67.495  ? 98   LYS A CE  1 
ATOM   665  N  NZ  . LYS A 1 80  ? -6.008  37.135 25.153 1 72.654  ? 98   LYS A NZ  1 
ATOM   666  N  N   . ALA A 1 81  ? -0.731  33.605 27.915 1 36.377  ? 99   ALA A N   1 
ATOM   667  C  CA  . ALA A 1 81  ? -0.991  33.103 29.257 1 37.75   ? 99   ALA A CA  1 
ATOM   668  C  C   . ALA A 1 81  ? 0.146   33.442 30.223 1 36.589  ? 99   ALA A C   1 
ATOM   669  O  O   . ALA A 1 81  ? -0.082  33.647 31.406 1 41.345  ? 99   ALA A O   1 
ATOM   670  C  CB  . ALA A 1 81  ? -1.257  31.618 29.208 1 38.158  ? 99   ALA A CB  1 
ATOM   671  N  N   . LEU A 1 82  ? 1.379   33.514 29.747 1 40.305  ? 100  LEU A N   1 
ATOM   672  C  CA  . LEU A 1 82  ? 2.495   33.867 30.62  1 44.491  ? 100  LEU A CA  1 
ATOM   673  C  C   . LEU A 1 82  ? 2.568   35.369 30.906 1 46.159  ? 100  LEU A C   1 
ATOM   674  O  O   . LEU A 1 82  ? 3.222   35.781 31.854 1 47.013  ? 100  LEU A O   1 
ATOM   675  C  CB  . LEU A 1 82  ? 3.775   33.402 29.943 1 48.066  ? 100  LEU A CB  1 
ATOM   676  C  CG  . LEU A 1 82  ? 3.846   31.914 29.61  1 48.72   ? 100  LEU A CG  1 
ATOM   677  C  CD1 . LEU A 1 82  ? 5.146   31.629 28.889 1 52.482  ? 100  LEU A CD1 1 
ATOM   678  C  CD2 . LEU A 1 82  ? 3.711   31.09  30.874 1 49.96   ? 100  LEU A CD2 1 
ATOM   679  N  N   . THR A 1 83  ? 1.943   36.206 30.076 1 50.49   ? 101  THR A N   1 
ATOM   680  C  CA  . THR A 1 83  ? 1.92    37.631 30.381 1 55.682  ? 101  THR A CA  1 
ATOM   681  C  C   . THR A 1 83  ? 0.942   37.894 31.53  1 50.159  ? 101  THR A C   1 
ATOM   682  O  O   . THR A 1 83  ? 1.119   38.875 32.232 1 55.314  ? 101  THR A O   1 
ATOM   683  C  CB  . THR A 1 83  ? 1.634   38.526 29.161 1 56.45   ? 101  THR A CB  1 
ATOM   684  O  OG1 . THR A 1 83  ? 0.301   38.379 28.666 1 59.231  ? 101  THR A OG1 1 
ATOM   685  C  CG2 . THR A 1 83  ? 2.619   38.301 28.027 1 54.942  ? 101  THR A CG2 1 
ATOM   686  N  N   . LYS A 1 84  ? -0.058  37.03  31.743 1 48.214  ? 102  LYS A N   1 
ATOM   687  C  CA  . LYS A 1 84  ? -1.095  37.271 32.738 1 49.675  ? 102  LYS A CA  1 
ATOM   688  C  C   . LYS A 1 84  ? -0.579  36.864 34.109 1 42.734  ? 102  LYS A C   1 
ATOM   689  O  O   . LYS A 1 84  ? -0.715  35.717 34.479 1 49.977  ? 102  LYS A O   1 
ATOM   690  C  CB  . LYS A 1 84  ? -2.411  36.527 32.454 1 62.676  ? 102  LYS A CB  1 
ATOM   691  C  CG  . LYS A 1 84  ? -3.49   37.317 31.687 1 81.315  ? 102  LYS A CG  1 
ATOM   692  C  CD  . LYS A 1 84  ? -4.203  36.589 30.537 1 97.674  ? 102  LYS A CD  1 
ATOM   693  C  CE  . LYS A 1 84  ? -4.926  35.299 30.87  1 104.981 ? 102  LYS A CE  1 
ATOM   694  N  NZ  . LYS A 1 84  ? -6.054  35.473 31.799 1 98.059  ? 102  LYS A NZ  1 
ATOM   695  N  N   . LEU A 1 85  ? -0.106  37.841 34.891 1 40.439  ? 103  LEU A N   1 
ATOM   696  C  CA  . LEU A 1 85  ? 0.562   37.622 36.168 1 35.532  ? 103  LEU A CA  1 
ATOM   697  C  C   . LEU A 1 85  ? -0.392  37.472 37.351 1 37.407  ? 103  LEU A C   1 
ATOM   698  O  O   . LEU A 1 85  ? 0.047   37.003 38.408 1 32.466  ? 103  LEU A O   1 
ATOM   699  C  CB  . LEU A 1 85  ? 1.443   38.835 36.46  1 36.079  ? 103  LEU A CB  1 
ATOM   700  C  CG  . LEU A 1 85  ? 2.801   38.897 35.765 1 41.736  ? 103  LEU A CG  1 
ATOM   701  C  CD1 . LEU A 1 85  ? 3.493   40.209 36.115 1 47.83   ? 103  LEU A CD1 1 
ATOM   702  C  CD2 . LEU A 1 85  ? 3.693   37.743 36.165 1 43.398  ? 103  LEU A CD2 1 
ATOM   703  N  N   . GLY A 1 86  ? -1.604  38.058 37.271 1 35.067  ? 104  GLY A N   1 
ATOM   704  C  CA  . GLY A 1 86  ? -2.482  38.106 38.436 1 29.944  ? 104  GLY A CA  1 
ATOM   705  C  C   . GLY A 1 86  ? -1.839  38.812 39.635 1 31.632  ? 104  GLY A C   1 
ATOM   706  O  O   . GLY A 1 86  ? -1.18   39.857 39.497 1 32.007  ? 104  GLY A O   1 
ATOM   707  N  N   . TYR A 1 87  ? -2.015  38.247 40.837 1 28.208  ? 105  TYR A N   1 
ATOM   708  C  CA  . TYR A 1 87  ? -1.475  38.886 42.032 1 30.285  ? 105  TYR A CA  1 
ATOM   709  C  C   . TYR A 1 87  ? 0.046   39.054 41.957 1 30.265  ? 105  TYR A C   1 
ATOM   710  O  O   . TYR A 1 87  ? 0.612   39.895 42.633 1 33.085  ? 105  TYR A O   1 
ATOM   711  C  CB  . TYR A 1 87  ? -1.835  38.08  43.283 1 33.387  ? 105  TYR A CB  1 
ATOM   712  C  CG  . TYR A 1 87  ? -3.323  37.976 43.609 1 37.528  ? 105  TYR A CG  1 
ATOM   713  C  CD1 . TYR A 1 87  ? -4.258  38.859 43.069 1 37.119  ? 105  TYR A CD1 1 
ATOM   714  C  CD2 . TYR A 1 87  ? -3.787  37.025 44.5   1 34.551  ? 105  TYR A CD2 1 
ATOM   715  C  CE1 . TYR A 1 87  ? -5.6    38.78  43.383 1 36.268  ? 105  TYR A CE1 1 
ATOM   716  C  CE2 . TYR A 1 87  ? -5.125  36.952 44.839 1 37.651  ? 105  TYR A CE2 1 
ATOM   717  C  CZ  . TYR A 1 87  ? -6.036  37.834 44.286 1 36.558  ? 105  TYR A CZ  1 
ATOM   718  O  OH  . TYR A 1 87  ? -7.361  37.775 44.596 1 35.664  ? 105  TYR A OH  1 
ATOM   719  N  N   . ALA A 1 88  ? 0.724   38.235 41.158 1 33.272  ? 106  ALA A N   1 
ATOM   720  C  CA  . ALA A 1 88  ? 2.179   38.224 41.116 1 36.265  ? 106  ALA A CA  1 
ATOM   721  C  C   . ALA A 1 88  ? 2.726   39.545 40.585 1 35.193  ? 106  ALA A C   1 
ATOM   722  O  O   . ALA A 1 88  ? 3.917   39.803 40.706 1 41.05   ? 106  ALA A O   1 
ATOM   723  C  CB  . ALA A 1 88  ? 2.67    37.062 40.271 1 32.995  ? 106  ALA A CB  1 
ATOM   724  N  N   . ALA A 1 89  ? 1.863   40.356 39.979 1 36.688  ? 107  ALA A N   1 
ATOM   725  C  CA  . ALA A 1 89  ? 2.263   41.656 39.473 1 33.722  ? 107  ALA A CA  1 
ATOM   726  C  C   . ALA A 1 89  ? 2.492   42.653 40.603 1 33.627  ? 107  ALA A C   1 
ATOM   727  O  O   . ALA A 1 89  ? 3.124   43.678 40.39  1 37.64   ? 107  ALA A O   1 
ATOM   728  C  CB  . ALA A 1 89  ? 1.216   42.165 38.527 1 32.874  ? 107  ALA A CB  1 
ATOM   729  N  N   . LEU A 1 90  ? 1.96    42.386 41.793 1 31.961  ? 108  LEU A N   1 
ATOM   730  C  CA  . LEU A 1 90  ? 2.143   43.292 42.911 1 34.359  ? 108  LEU A CA  1 
ATOM   731  C  C   . LEU A 1 90  ? 3.629   43.454 43.254 1 38.981  ? 108  LEU A C   1 
ATOM   732  O  O   . LEU A 1 90  ? 4.419   42.522 43.156 1 39.742  ? 108  LEU A O   1 
ATOM   733  C  CB  . LEU A 1 90  ? 1.374   42.777 44.124 1 33.466  ? 108  LEU A CB  1 
ATOM   734  C  CG  . LEU A 1 90  ? -0.149  42.914 44.066 1 36.97   ? 108  LEU A CG  1 
ATOM   735  C  CD1 . LEU A 1 90  ? -0.738  42.179 45.239 1 38.237  ? 108  LEU A CD1 1 
ATOM   736  C  CD2 . LEU A 1 90  ? -0.572  44.36  44.074 1 37.836  ? 108  LEU A CD2 1 
ATOM   737  N  N   . PRO A 1 91  ? 4.072   44.654 43.678 1 44.965  ? 109  PRO A N   1 
ATOM   738  C  CA  . PRO A 1 91  ? 5.335   44.765 44.396 1 48.276  ? 109  PRO A CA  1 
ATOM   739  C  C   . PRO A 1 91  ? 5.446   43.752 45.531 1 44.382  ? 109  PRO A C   1 
ATOM   740  O  O   . PRO A 1 91  ? 4.446   43.392 46.14  1 44.443  ? 109  PRO A O   1 
ATOM   741  C  CB  . PRO A 1 91  ? 5.376   46.218 44.891 1 47.695  ? 109  PRO A CB  1 
ATOM   742  C  CG  . PRO A 1 91  ? 4.047   46.842 44.47  1 51.326  ? 109  PRO A CG  1 
ATOM   743  C  CD  . PRO A 1 91  ? 3.436   45.954 43.409 1 48.686  ? 109  PRO A CD  1 
ATOM   744  N  N   . GLU A 1 92  ? 6.681   43.337 45.826 1 41.286  ? 110  GLU A N   1 
ATOM   745  C  CA  . GLU A 1 92  ? 6.916   42.151 46.62  1 47.135  ? 110  GLU A CA  1 
ATOM   746  C  C   . GLU A 1 92  ? 6.319   42.335 48.014 1 44.546  ? 110  GLU A C   1 
ATOM   747  O  O   . GLU A 1 92  ? 5.791   41.38  48.573 1 48.055  ? 110  GLU A O   1 
ATOM   748  C  CB  . GLU A 1 92  ? 8.383   41.715 46.559 1 51.855  ? 110  GLU A CB  1 
ATOM   749  C  CG  . GLU A 1 92  ? 9.244   42.168 47.731 1 64.698  ? 110  GLU A CG  1 
ATOM   750  C  CD  . GLU A 1 92  ? 10.676  41.632 47.713 1 75.993  ? 110  GLU A CD  1 
ATOM   751  O  OE1 . GLU A 1 92  ? 10.957  40.579 47.071 1 76.201  ? 110  GLU A OE1 1 
ATOM   752  O  OE2 . GLU A 1 92  ? 11.527  42.312 48.341 1 72.641  ? 110  GLU A OE2 1 
ATOM   753  N  N   . ASP A 1 93  ? 6.372   43.549 48.563 1 44.252  ? 111  ASP A N   1 
ATOM   754  C  CA  . ASP A 1 93  ? 5.854   43.813 49.902 1 45.824  ? 111  ASP A CA  1 
ATOM   755  C  C   . ASP A 1 93  ? 4.323   43.755 49.923 1 44.147  ? 111  ASP A C   1 
ATOM   756  O  O   . ASP A 1 93  ? 3.72    43.33  50.904 1 44.093  ? 111  ASP A O   1 
ATOM   757  C  CB  . ASP A 1 93  ? 6.357   45.149 50.429 1 51.832  ? 111  ASP A CB  1 
ATOM   758  C  CG  . ASP A 1 93  ? 7.775   45.156 50.997 1 68.152  ? 111  ASP A CG  1 
ATOM   759  O  OD1 . ASP A 1 93  ? 8.408   44.075 51.095 1 69.973  ? 111  ASP A OD1 1 
ATOM   760  O  OD2 . ASP A 1 93  ? 8.246   46.253 51.348 1 77.398  ? 111  ASP A OD2 1 
ATOM   761  N  N   . ASP A 1 94  ? 3.697   44.226 48.845 1 39.763  ? 112  ASP A N   1 
ATOM   762  C  CA  . ASP A 1 94  ? 2.257   44.2   48.741 1 40.739  ? 112  ASP A CA  1 
ATOM   763  C  C   . ASP A 1 94  ? 1.794   42.774 48.513 1 37.868  ? 112  ASP A C   1 
ATOM   764  O  O   . ASP A 1 94  ? 0.765   42.388 49.049 1 36.105  ? 112  ASP A O   1 
ATOM   765  C  CB  . ASP A 1 94  ? 1.775   45.071 47.605 1 42.909  ? 112  ASP A CB  1 
ATOM   766  C  CG  . ASP A 1 94  ? 1.81    46.56  47.885 1 45.898  ? 112  ASP A CG  1 
ATOM   767  O  OD1 . ASP A 1 94  ? 1.922   46.95  49.073 1 47.983  ? 112  ASP A OD1 1 
ATOM   768  O  OD2 . ASP A 1 94  ? 1.719   47.302 46.904 1 53.461  ? 112  ASP A OD2 1 
ATOM   769  N  N   . TYR A 1 95  ? 2.564   42.004 47.738 1 33.935  ? 113  TYR A N   1 
ATOM   770  C  CA  . TYR A 1 95  ? 2.233   40.607 47.54  1 34.473  ? 113  TYR A CA  1 
ATOM   771  C  C   . TYR A 1 95  ? 2.277   39.848 48.869 1 37.094  ? 113  TYR A C   1 
ATOM   772  O  O   . TYR A 1 95  ? 1.38    39.069 49.162 1 41.822  ? 113  TYR A O   1 
ATOM   773  C  CB  . TYR A 1 95  ? 3.1     40.023 46.435 1 34.327  ? 113  TYR A CB  1 
ATOM   774  C  CG  . TYR A 1 95  ? 2.673   38.608 46.104 1 37.807  ? 113  TYR A CG  1 
ATOM   775  C  CD1 . TYR A 1 95  ? 1.51    38.344 45.403 1 45.817  ? 113  TYR A CD1 1 
ATOM   776  C  CD2 . TYR A 1 95  ? 3.426   37.533 46.513 1 40.987  ? 113  TYR A CD2 1 
ATOM   777  C  CE1 . TYR A 1 95  ? 1.101   37.047 45.131 1 43.674  ? 113  TYR A CE1 1 
ATOM   778  C  CE2 . TYR A 1 95  ? 3.038   36.236 46.235 1 43.424  ? 113  TYR A CE2 1 
ATOM   779  C  CZ  . TYR A 1 95  ? 1.874   35.987 45.547 1 41.024  ? 113  TYR A CZ  1 
ATOM   780  O  OH  . TYR A 1 95  ? 1.557   34.686 45.308 1 43.376  ? 113  TYR A OH  1 
ATOM   781  N  N   . ALA A 1 96  ? 3.273   40.112 49.715 1 39.791  ? 114  ALA A N   1 
ATOM   782  C  CA  . ALA A 1 96  ? 3.418   39.363 50.955 1 41.19   ? 114  ALA A CA  1 
ATOM   783  C  C   . ALA A 1 96  ? 2.279   39.711 51.909 1 37.608  ? 114  ALA A C   1 
ATOM   784  O  O   . ALA A 1 96  ? 1.839   38.874 52.692 1 41.272  ? 114  ALA A O   1 
ATOM   785  C  CB  . ALA A 1 96  ? 4.766   39.638 51.586 1 39.106  ? 114  ALA A CB  1 
ATOM   786  N  N   . GLU A 1 97  ? 1.847   40.967 51.857 1 36.555  ? 115  GLU A N   1 
ATOM   787  C  CA  . GLU A 1 97  ? 0.76    41.44  52.69  1 39.437  ? 115  GLU A CA  1 
ATOM   788  C  C   . GLU A 1 97  ? -0.56   40.806 52.233 1 39.532  ? 115  GLU A C   1 
ATOM   789  O  O   . GLU A 1 97  ? -1.408  40.474 53.06  1 39.335  ? 115  GLU A O   1 
ATOM   790  C  CB  . GLU A 1 97  ? 0.679   42.966 52.665 1 39.948  ? 115  GLU A CB  1 
ATOM   791  C  CG  . GLU A 1 97  ? -0.34   43.492 53.676 1 42.929  ? 115  GLU A CG  1 
ATOM   792  C  CD  . GLU A 1 97  ? -0.586  44.994 53.677 1 47.242  ? 115  GLU A CD  1 
ATOM   793  O  OE1 . GLU A 1 97  ? 0.133   45.684 52.915 1 44.922  ? 115  GLU A OE1 1 
ATOM   794  O  OE2 . GLU A 1 97  ? -1.494  45.468 54.428 1 47.369  ? 115  GLU A OE2 1 
ATOM   795  N  N   . LEU A 1 98  ? -0.733  40.644 50.915 1 35.902  ? 116  LEU A N   1 
ATOM   796  C  CA  . LEU A 1 98  ? -1.922  40.004 50.384 1 36.846  ? 116  LEU A CA  1 
ATOM   797  C  C   . LEU A 1 98  ? -1.972  38.544 50.852 1 37.909  ? 116  LEU A C   1 
ATOM   798  O  O   . LEU A 1 98  ? -3.02   38.061 51.264 1 37.252  ? 116  LEU A O   1 
ATOM   799  C  CB  . LEU A 1 98  ? -1.995  40.113 48.863 1 33.786  ? 116  LEU A CB  1 
ATOM   800  C  CG  . LEU A 1 98  ? -3.21   39.436 48.225 1 34.167  ? 116  LEU A CG  1 
ATOM   801  C  CD1 . LEU A 1 98  ? -4.541  39.939 48.767 1 34.742  ? 116  LEU A CD1 1 
ATOM   802  C  CD2 . LEU A 1 98  ? -3.173  39.666 46.743 1 37.542  ? 116  LEU A CD2 1 
ATOM   803  N  N   . LEU A 1 99  ? -0.849  37.824 50.773 1 38.823  ? 117  LEU A N   1 
ATOM   804  C  CA  . LEU A 1 99  ? -0.833  36.431 51.183 1 38.427  ? 117  LEU A CA  1 
ATOM   805  C  C   . LEU A 1 99  ? -1.147  36.325 52.667 1 35.856  ? 117  LEU A C   1 
ATOM   806  O  O   . LEU A 1 99  ? -1.875  35.426 53.072 1 37.123  ? 117  LEU A O   1 
ATOM   807  C  CB  . LEU A 1 99  ? 0.519   35.819 50.847 1 42.043  ? 117  LEU A CB  1 
ATOM   808  C  CG  . LEU A 1 99  ? 0.79    35.594 49.359 1 44.681  ? 117  LEU A CG  1 
ATOM   809  C  CD1 . LEU A 1 99  ? 2.253   35.212 49.236 1 48.762  ? 117  LEU A CD1 1 
ATOM   810  C  CD2 . LEU A 1 99  ? -0.098  34.545 48.729 1 45.542  ? 117  LEU A CD2 1 
ATOM   811  N  N   . ASP A 1 100 ? -0.609  37.245 53.468 1 36.327  ? 118  ASP A N   1 
ATOM   812  C  CA  . ASP A 1 100 ? -0.853  37.22  54.903 1 42.036  ? 118  ASP A CA  1 
ATOM   813  C  C   . ASP A 1 100 ? -2.328  37.494 55.156 1 40.197  ? 118  ASP A C   1 
ATOM   814  O  O   . ASP A 1 100 ? -2.887  36.92  56.086 1 36.374  ? 118  ASP A O   1 
ATOM   815  C  CB  . ASP A 1 100 ? 0.03    38.173 55.709 1 49.022  ? 118  ASP A CB  1 
ATOM   816  C  CG  . ASP A 1 100 ? 1.531   37.857 55.758 1 68.823  ? 118  ASP A CG  1 
ATOM   817  O  OD1 . ASP A 1 100 ? 2.011   36.885 55.093 1 74.407  ? 118  ASP A OD1 1 
ATOM   818  O  OD2 . ASP A 1 100 ? 2.248   38.604 56.449 1 76.823  ? 118  ASP A OD2 1 
ATOM   819  N  N   . THR A 1 101 ? -2.933  38.399 54.358 1 39.687  ? 119  THR A N   1 
ATOM   820  C  CA  . THR A 1 101 ? -4.352  38.717 54.499 1 38.118  ? 119  THR A CA  1 
ATOM   821  C  C   . THR A 1 101 ? -5.213  37.486 54.172 1 35.251  ? 119  THR A C   1 
ATOM   822  O  O   . THR A 1 101 ? -6.104  37.136 54.94  1 31.602  ? 119  THR A O   1 
ATOM   823  C  CB  . THR A 1 101 ? -4.716  39.894 53.606 1 35.672  ? 119  THR A CB  1 
ATOM   824  O  OG1 . THR A 1 101 ? -3.946  40.986 54.076 1 32.365  ? 119  THR A OG1 1 
ATOM   825  C  CG2 . THR A 1 101 ? -6.175  40.268 53.743 1 38.945  ? 119  THR A CG2 1 
ATOM   826  N  N   . LEU A 1 102 ? -4.911  36.804 53.056 1 30.99   ? 120  LEU A N   1 
ATOM   827  C  CA  . LEU A 1 102 ? -5.658  35.625 52.633 1 35.794  ? 120  LEU A CA  1 
ATOM   828  C  C   . LEU A 1 102 ? -5.575  34.504 53.674 1 35.852  ? 120  LEU A C   1 
ATOM   829  O  O   . LEU A 1 102 ? -6.572  33.837 53.935 1 39.682  ? 120  LEU A O   1 
ATOM   830  C  CB  . LEU A 1 102 ? -5.172  35.141 51.267 1 32.049  ? 120  LEU A CB  1 
ATOM   831  C  CG  . LEU A 1 102 ? -5.396  36.126 50.118 1 34.841  ? 120  LEU A CG  1 
ATOM   832  C  CD1 . LEU A 1 102 ? -4.779  35.603 48.822 1 37.431  ? 120  LEU A CD1 1 
ATOM   833  C  CD2 . LEU A 1 102 ? -6.886  36.44  49.954 1 34.875  ? 120  LEU A CD2 1 
ATOM   834  N  N   . SER A 1 103 ? -4.378  34.288 54.223 1 38.69   ? 121  SER A N   1 
ATOM   835  C  CA  . SER A 1 103 ? -4.116  33.295 55.26  1 43.147  ? 121  SER A CA  1 
ATOM   836  C  C   . SER A 1 103 ? -4.947  33.566 56.511 1 35.283  ? 121  SER A C   1 
ATOM   837  O  O   . SER A 1 103 ? -5.524  32.662 57.113 1 38.41   ? 121  SER A O   1 
ATOM   838  C  CB  . SER A 1 103 ? -2.641  33.269 55.612 1 42.533  ? 121  SER A CB  1 
ATOM   839  O  OG  . SER A 1 103 ? -1.953  32.572 54.596 1 48.117  ? 121  SER A OG  1 
ATOM   840  N  N   . ALA A 1 104 ? -4.95   34.819 56.933 1 31.13   ? 122  ALA A N   1 
ATOM   841  C  CA  . ALA A 1 104 ? -5.724  35.201 58.096 1 34.624  ? 122  ALA A CA  1 
ATOM   842  C  C   . ALA A 1 104 ? -7.208  34.847 57.906 1 34.333  ? 122  ALA A C   1 
ATOM   843  O  O   . ALA A 1 104 ? -7.839  34.346 58.834 1 33.888  ? 122  ALA A O   1 
ATOM   844  C  CB  . ALA A 1 104 ? -5.491  36.67  58.385 1 32.455  ? 122  ALA A CB  1 
ATOM   845  N  N   . MET A 1 105 ? -7.758  35.101 56.712 1 32.906  ? 123  MET A N   1 
ATOM   846  C  CA  . MET A 1 105 ? -9.173  34.873 56.463 1 37.704  ? 123  MET A CA  1 
ATOM   847  C  C   . MET A 1 105 ? -9.484  33.377 56.399 1 32.785  ? 123  MET A C   1 
ATOM   848  O  O   . MET A 1 105 ? -10.443 32.921 57.021 1 35.393  ? 123  MET A O   1 
ATOM   849  C  CB  . MET A 1 105 ? -9.636  35.593 55.193 1 35.916  ? 123  MET A CB  1 
ATOM   850  C  CG  . MET A 1 105 ? -9.615  37.1   55.341 1 42.764  ? 123  MET A CG  1 
ATOM   851  S  SD  . MET A 1 105 ? -10.468 38     54.03  1 41.731  ? 123  MET A SD  1 
ATOM   852  C  CE  . MET A 1 105 ? -9.564  37.447 52.583 1 35.125  ? 123  MET A CE  1 
ATOM   853  N  N   . GLU A 1 106 ? -8.685  32.621 55.646 1 33.147  ? 124  GLU A N   1 
ATOM   854  C  CA  . GLU A 1 106 ? -8.968  31.213 55.424 1 37.528  ? 124  GLU A CA  1 
ATOM   855  C  C   . GLU A 1 106 ? -8.828  30.441 56.737 1 36.837  ? 124  GLU A C   1 
ATOM   856  O  O   . GLU A 1 106 ? -9.559  29.492 56.968 1 38.728  ? 124  GLU A O   1 
ATOM   857  C  CB  . GLU A 1 106 ? -8.095  30.644 54.308 1 44.838  ? 124  GLU A CB  1 
ATOM   858  C  CG  . GLU A 1 106 ? -8.485  29.223 53.89  1 55.889  ? 124  GLU A CG  1 
ATOM   859  C  CD  . GLU A 1 106 ? -7.87   28.641 52.609 1 59.339  ? 124  GLU A CD  1 
ATOM   860  O  OE1 . GLU A 1 106 ? -8.416  27.607 52.145 1 54.786  ? 124  GLU A OE1 1 
ATOM   861  O  OE2 . GLU A 1 106 ? -6.863  29.161 52.07  1 60.74   ? 124  GLU A OE2 1 
ATOM   862  N  N   . SER A 1 107 ? -7.89   30.84  57.6   1 35.824  ? 125  SER A N   1 
ATOM   863  C  CA  . SER A 1 107 ? -7.659  30.118 58.839 1 41.038  ? 125  SER A CA  1 
ATOM   864  C  C   . SER A 1 107 ? -8.64   30.573 59.914 1 38.594  ? 125  SER A C   1 
ATOM   865  O  O   . SER A 1 107 ? -9.041  29.772 60.754 1 43.202  ? 125  SER A O   1 
ATOM   866  C  CB  . SER A 1 107 ? -6.217  30.226 59.303 1 40.688  ? 125  SER A CB  1 
ATOM   867  O  OG  . SER A 1 107 ? -5.902  31.551 59.69  1 39.242  ? 125  SER A OG  1 
ATOM   868  N  N   . ASN A 1 108 ? -9.043  31.847 59.889 1 38.246  ? 126  ASN A N   1 
ATOM   869  C  CA  . ASN A 1 108 ? -10.176 32.261 60.704 1 37.659  ? 126  ASN A CA  1 
ATOM   870  C  C   . ASN A 1 108 ? -11.366 31.357 60.37  1 36.888  ? 126  ASN A C   1 
ATOM   871  O  O   . ASN A 1 108 ? -11.965 30.735 61.244 1 34.498  ? 126  ASN A O   1 
ATOM   872  C  CB  . ASN A 1 108 ? -10.517 33.736 60.543 1 34.954  ? 126  ASN A CB  1 
ATOM   873  C  CG  . ASN A 1 108 ? -11.79  34.063 61.278 1 37.265  ? 126  ASN A CG  1 
ATOM   874  O  OD1 . ASN A 1 108 ? -11.778 34.296 62.485 1 37.206  ? 126  ASN A OD1 1 
ATOM   875  N  ND2 . ASN A 1 108 ? -12.914 34.051 60.582 1 38.215  ? 126  ASN A ND2 1 
ATOM   876  N  N   . PHE A 1 109 ? -11.682 31.235 59.083 1 32.154  ? 127  PHE A N   1 
ATOM   877  C  CA  . PHE A 1 109 ? -12.842 30.446 58.712 1 32.612  ? 127  PHE A CA  1 
ATOM   878  C  C   . PHE A 1 109 ? -12.7   29.007 59.209 1 32.948  ? 127  PHE A C   1 
ATOM   879  O  O   . PHE A 1 109 ? -13.655 28.447 59.724 1 31.39   ? 127  PHE A O   1 
ATOM   880  C  CB  . PHE A 1 109 ? -13.027 30.441 57.191 1 31.854  ? 127  PHE A CB  1 
ATOM   881  C  CG  . PHE A 1 109 ? -14.243 29.663 56.723 1 28.084  ? 127  PHE A CG  1 
ATOM   882  C  CD1 . PHE A 1 109 ? -14.18  28.296 56.536 1 28.055  ? 127  PHE A CD1 1 
ATOM   883  C  CD2 . PHE A 1 109 ? -15.465 30.297 56.539 1 29.382  ? 127  PHE A CD2 1 
ATOM   884  C  CE1 . PHE A 1 109 ? -15.284 27.584 56.116 1 30.376  ? 127  PHE A CE1 1 
ATOM   885  C  CE2 . PHE A 1 109 ? -16.569 29.583 56.112 1 30.649  ? 127  PHE A CE2 1 
ATOM   886  C  CZ  . PHE A 1 109 ? -16.479 28.23  55.905 1 32.774  ? 127  PHE A CZ  1 
ATOM   887  N  N   . ALA A 1 110 ? -11.535 28.378 58.986 1 36.285  ? 128  ALA A N   1 
ATOM   888  C  CA  . ALA A 1 110 ? -11.357 26.958 59.266 1 35.761  ? 128  ALA A CA  1 
ATOM   889  C  C   . ALA A 1 110 ? -11.315 26.696 60.77  1 36.775  ? 128  ALA A C   1 
ATOM   890  O  O   . ALA A 1 110 ? -11.564 25.583 61.195 1 41.392  ? 128  ALA A O   1 
ATOM   891  C  CB  . ALA A 1 110 ? -10.101 26.442 58.609 1 38.312  ? 128  ALA A CB  1 
ATOM   892  N  N   . LYS A 1 111 ? -11.003 27.701 61.589 1 36.323  ? 129  LYS A N   1 
ATOM   893  C  CA  . LYS A 1 111 ? -10.907 27.463 63.017 1 38.954  ? 129  LYS A CA  1 
ATOM   894  C  C   . LYS A 1 111 ? -12.143 27.913 63.796 1 39.281  ? 129  LYS A C   1 
ATOM   895  O  O   . LYS A 1 111 ? -12.109 27.988 65.011 1 40.418  ? 129  LYS A O   1 
ATOM   896  C  CB  . LYS A 1 111 ? -9.693  28.215 63.554 1 42.431  ? 129  LYS A CB  1 
ATOM   897  C  CG  . LYS A 1 111 ? -8.355  27.61  63.191 1 49.245  ? 129  LYS A CG  1 
ATOM   898  C  CD  . LYS A 1 111 ? -7.283  28.515 63.784 1 54.439  ? 129  LYS A CD  1 
ATOM   899  C  CE  . LYS A 1 111 ? -5.907  28.019 63.614 1 62.908  ? 129  LYS A CE  1 
ATOM   900  N  NZ  . LYS A 1 111 ? -5.012  29.122 63.969 1 67.203  ? 129  LYS A NZ  1 
ATOM   901  N  N   . VAL A 1 112 ? -13.252 28.205 63.125 1 43.209  ? 130  VAL A N   1 
ATOM   902  C  CA  . VAL A 1 112 ? -14.446 28.624 63.831 1 37.19   ? 130  VAL A CA  1 
ATOM   903  C  C   . VAL A 1 112 ? -14.965 27.468 64.683 1 36.001  ? 130  VAL A C   1 
ATOM   904  O  O   . VAL A 1 112 ? -15.209 26.375 64.175 1 33.817  ? 130  VAL A O   1 
ATOM   905  C  CB  . VAL A 1 112 ? -15.508 29.122 62.83  1 37.272  ? 130  VAL A CB  1 
ATOM   906  C  CG1 . VAL A 1 112 ? -16.875 29.316 63.485 1 37.271  ? 130  VAL A CG1 1 
ATOM   907  C  CG2 . VAL A 1 112 ? -15.063 30.411 62.162 1 35.179  ? 130  VAL A CG2 1 
ATOM   908  N  N   . LYS A 1 113 ? -15.204 27.749 65.971 1 39.837  ? 131  LYS A N   1 
ATOM   909  C  CA  . LYS A 1 113 ? -15.903 26.827 66.848 1 40.951  ? 131  LYS A CA  1 
ATOM   910  C  C   . LYS A 1 113 ? -17.008 27.589 67.556 1 35.604  ? 131  LYS A C   1 
ATOM   911  O  O   . LYS A 1 113 ? -16.81  28.748 67.841 1 37.476  ? 131  LYS A O   1 
ATOM   912  C  CB  . LYS A 1 113 ? -14.966 26.289 67.933 1 49.816  ? 131  LYS A CB  1 
ATOM   913  C  CG  . LYS A 1 113 ? -13.778 25.465 67.456 1 54.022  ? 131  LYS A CG  1 
ATOM   914  C  CD  . LYS A 1 113 ? -14.171 24.269 66.603 1 65.827  ? 131  LYS A CD  1 
ATOM   915  C  CE  . LYS A 1 113 ? -13.297 23.068 66.827 1 69.637  ? 131  LYS A CE  1 
ATOM   916  N  NZ  . LYS A 1 113 ? -11.917 23.4   66.489 1 68.83   ? 131  LYS A NZ  1 
ATOM   917  N  N   . VAL A 1 114 ? -18.131 26.936 67.88  1 38.721  ? 132  VAL A N   1 
ATOM   918  C  CA  . VAL A 1 114 ? -19.231 27.586 68.582 1 41.246  ? 132  VAL A CA  1 
ATOM   919  C  C   . VAL A 1 114 ? -19.67  26.716 69.758 1 40.987  ? 132  VAL A C   1 
ATOM   920  O  O   . VAL A 1 114 ? -19.383 25.521 69.804 1 36.196  ? 132  VAL A O   1 
ATOM   921  C  CB  . VAL A 1 114 ? -20.436 27.87  67.657 1 40.144  ? 132  VAL A CB  1 
ATOM   922  C  CG1 . VAL A 1 114 ? -20.015 28.55  66.372 1 40.433  ? 132  VAL A CG1 1 
ATOM   923  C  CG2 . VAL A 1 114 ? -21.181 26.605 67.292 1 42.842  ? 132  VAL A CG2 1 
ATOM   924  N  N   . CYS A 1 115 ? -20.457 27.327 70.652 1 45.384  ? 133  CYS A N   1 
ATOM   925  C  CA  . CYS A 1 115 ? -20.977 26.663 71.837 1 45.028  ? 133  CYS A CA  1 
ATOM   926  C  C   . CYS A 1 115 ? -22.282 25.941 71.519 1 44.138  ? 133  CYS A C   1 
ATOM   927  O  O   . CYS A 1 115 ? -23.065 26.423 70.714 1 41.695  ? 133  CYS A O   1 
ATOM   928  C  CB  . CYS A 1 115 ? -21.112 27.675 72.963 1 48.203  ? 133  CYS A CB  1 
ATOM   929  S  SG  . CYS A 1 115 ? -19.51  28.423 73.385 1 64.566  ? 133  CYS A SG  1 
ATOM   930  N  N   . ASP A 1 116 ? -22.492 24.773 72.149 1 45.723  ? 134  ASP A N   1 
ATOM   931  C  CA  . ASP A 1 116 ? -23.719 24.004 71.995 1 49.718  ? 134  ASP A CA  1 
ATOM   932  C  C   . ASP A 1 116 ? -24.887 24.838 72.519 1 51.287  ? 134  ASP A C   1 
ATOM   933  O  O   . ASP A 1 116 ? -24.752 25.52  73.539 1 47.778  ? 134  ASP A O   1 
ATOM   934  C  CB  . ASP A 1 116 ? -23.656 22.688 72.749 1 49.587  ? 134  ASP A CB  1 
ATOM   935  C  CG  . ASP A 1 116 ? -24.644 21.601 72.343 1 55.283  ? 134  ASP A CG  1 
ATOM   936  O  OD1 . ASP A 1 116 ? -25.873 21.824 72.436 1 59.981  ? 134  ASP A OD1 1 
ATOM   937  O  OD2 . ASP A 1 116 ? -24.168 20.499 71.974 1 63.512  ? 134  ASP A OD2 1 
ATOM   938  N  N   . TYR A 1 117 ? -26.025 24.768 71.811 1 51.149  ? 135  TYR A N   1 
ATOM   939  C  CA  . TYR A 1 117 ? -27.239 25.49  72.181 1 51.467  ? 135  TYR A CA  1 
ATOM   940  C  C   . TYR A 1 117 ? -27.724 25.054 73.564 1 50.551  ? 135  TYR A C   1 
ATOM   941  O  O   . TYR A 1 117 ? -28.186 25.884 74.334 1 47.27   ? 135  TYR A O   1 
ATOM   942  C  CB  . TYR A 1 117 ? -28.259 25.252 71.059 1 48.781  ? 135  TYR A CB  1 
ATOM   943  C  CG  . TYR A 1 117 ? -29.65  25.852 71.218 1 42.924  ? 135  TYR A CG  1 
ATOM   944  C  CD1 . TYR A 1 117 ? -29.851 27.229 71.338 1 40.538  ? 135  TYR A CD1 1 
ATOM   945  C  CD2 . TYR A 1 117 ? -30.77  25.033 71.157 1 42.656  ? 135  TYR A CD2 1 
ATOM   946  C  CE1 . TYR A 1 117 ? -31.129 27.766 71.446 1 43.243  ? 135  TYR A CE1 1 
ATOM   947  C  CE2 . TYR A 1 117 ? -32.05  25.557 71.253 1 45.594  ? 135  TYR A CE2 1 
ATOM   948  C  CZ  . TYR A 1 117 ? -32.231 26.924 71.402 1 44.858  ? 135  TYR A CZ  1 
ATOM   949  O  OH  . TYR A 1 117 ? -33.508 27.381 71.507 1 46.309  ? 135  TYR A OH  1 
ATOM   950  N  N   . LYS A 1 118 ? -27.567 23.76  73.86  1 56.429  ? 136  LYS A N   1 
ATOM   951  C  CA  . LYS A 1 118 ? -28.063 23.131 75.075 1 66.651  ? 136  LYS A CA  1 
ATOM   952  C  C   . LYS A 1 118 ? -27.001 23.014 76.17  1 69.841  ? 136  LYS A C   1 
ATOM   953  O  O   . LYS A 1 118 ? -27.275 22.395 77.195 1 68.867  ? 136  LYS A O   1 
ATOM   954  C  CB  . LYS A 1 118 ? -28.498 21.713 74.697 1 70.199  ? 136  LYS A CB  1 
ATOM   955  C  CG  . LYS A 1 118 ? -29.677 21.718 73.746 1 84.686  ? 136  LYS A CG  1 
ATOM   956  C  CD  . LYS A 1 118 ? -29.742 20.591 72.719 1 88.359  ? 136  LYS A CD  1 
ATOM   957  C  CE  . LYS A 1 118 ? -31.021 20.741 71.931 1 90.319  ? 136  LYS A CE  1 
ATOM   958  N  NZ  . LYS A 1 118 ? -31.3   19.676 70.961 1 90.13   ? 136  LYS A NZ  1 
ATOM   959  N  N   . ASP A 1 119 ? -25.802 23.588 75.965 1 65.983  ? 137  ASP A N   1 
ATOM   960  C  CA  . ASP A 1 119 ? -24.691 23.386 76.882 1 59.63   ? 137  ASP A CA  1 
ATOM   961  C  C   . ASP A 1 119 ? -23.539 24.318 76.521 1 56.748  ? 137  ASP A C   1 
ATOM   962  O  O   . ASP A 1 119 ? -22.701 23.956 75.702 1 54.692  ? 137  ASP A O   1 
ATOM   963  C  CB  . ASP A 1 119 ? -24.205 21.939 76.858 1 64.053  ? 137  ASP A CB  1 
ATOM   964  C  CG  . ASP A 1 119 ? -23.09  21.575 77.841 1 70.017  ? 137  ASP A CG  1 
ATOM   965  O  OD1 . ASP A 1 119 ? -22.727 22.424 78.698 1 63.887  ? 137  ASP A OD1 1 
ATOM   966  O  OD2 . ASP A 1 119 ? -22.58  20.434 77.745 1 63.662  ? 137  ASP A OD2 1 
ATOM   967  N  N   . SER A 1 120 ? -23.454 25.475 77.188 1 59.064  ? 138  SER A N   1 
ATOM   968  C  CA  . SER A 1 120 ? -22.465 26.481 76.831 1 75.321  ? 138  SER A CA  1 
ATOM   969  C  C   . SER A 1 120 ? -21.11  26.2   77.487 1 73.733  ? 138  SER A C   1 
ATOM   970  O  O   . SER A 1 120 ? -20.198 27.025 77.385 1 61.146  ? 138  SER A O   1 
ATOM   971  C  CB  . SER A 1 120 ? -22.958 27.882 77.139 1 79.49   ? 138  SER A CB  1 
ATOM   972  O  OG  . SER A 1 120 ? -23.397 27.971 78.482 1 74.936  ? 138  SER A OG  1 
ATOM   973  N  N   . THR A 1 121 ? -20.977 25.035 78.138 1 75.214  ? 139  THR A N   1 
ATOM   974  C  CA  . THR A 1 121 ? -19.673 24.54  78.555 1 77.858  ? 139  THR A CA  1 
ATOM   975  C  C   . THR A 1 121 ? -18.982 23.911 77.343 1 69.679  ? 139  THR A C   1 
ATOM   976  O  O   . THR A 1 121 ? -17.765 23.993 77.214 1 70.335  ? 139  THR A O   1 
ATOM   977  C  CB  . THR A 1 121 ? -19.776 23.537 79.714 1 81.085  ? 139  THR A CB  1 
ATOM   978  O  OG1 . THR A 1 121 ? -20.161 22.268 79.188 1 79.329  ? 139  THR A OG1 1 
ATOM   979  C  CG2 . THR A 1 121 ? -20.733 23.978 80.809 1 82.909  ? 139  THR A CG2 1 
ATOM   980  N  N   . LYS A 1 122 ? -19.767 23.273 76.468 1 56.375  ? 140  LYS A N   1 
ATOM   981  C  CA  . LYS A 1 122 ? -19.23  22.513 75.355 1 54.251  ? 140  LYS A CA  1 
ATOM   982  C  C   . LYS A 1 122 ? -19.057 23.437 74.14  1 54.131  ? 140  LYS A C   1 
ATOM   983  O  O   . LYS A 1 122 ? -20.008 23.681 73.402 1 53.312  ? 140  LYS A O   1 
ATOM   984  C  CB  . LYS A 1 122 ? -20.175 21.313 75.219 1 57.258  ? 140  LYS A CB  1 
ATOM   985  C  CG  . LYS A 1 122 ? -19.942 20.435 74.015 1 68.351  ? 140  LYS A CG  1 
ATOM   986  C  CD  . LYS A 1 122 ? -20.514 19.026 74.145 1 82.52   ? 140  LYS A CD  1 
ATOM   987  C  CE  . LYS A 1 122 ? -20.675 18.328 72.812 1 87.788  ? 140  LYS A CE  1 
ATOM   988  N  NZ  . LYS A 1 122 ? -19.471 18.4   71.971 1 86.105  ? 140  LYS A NZ  1 
ATOM   989  N  N   . CYS A 1 123 ? -17.822 23.919 73.91  1 51.165  ? 141  CYS A N   1 
ATOM   990  C  CA  . CYS A 1 123 ? -17.552 24.992 72.96  1 51.011  ? 141  CYS A CA  1 
ATOM   991  C  C   . CYS A 1 123 ? -16.603 24.56  71.835 1 44.738  ? 141  CYS A C   1 
ATOM   992  O  O   . CYS A 1 123 ? -15.782 25.347 71.386 1 43.284  ? 141  CYS A O   1 
ATOM   993  C  CB  . CYS A 1 123 ? -17.095 26.234 73.718 1 53.705  ? 141  CYS A CB  1 
ATOM   994  S  SG  . CYS A 1 123 ? -18.463 26.997 74.642 1 84.144  ? 141  CYS A SG  1 
ATOM   995  N  N   . ASP A 1 124 ? -16.764 23.344 71.303 1 44.875  ? 142  ASP A N   1 
ATOM   996  C  CA  . ASP A 1 124 ? -15.842 22.823 70.303 1 48.974  ? 142  ASP A CA  1 
ATOM   997  C  C   . ASP A 1 124 ? -16.615 22.283 69.095 1 46.817  ? 142  ASP A C   1 
ATOM   998  O  O   . ASP A 1 124 ? -16.199 21.289 68.482 1 42.233  ? 142  ASP A O   1 
ATOM   999  C  CB  . ASP A 1 124 ? -14.991 21.72  70.911 1 54.855  ? 142  ASP A CB  1 
ATOM   1000 C  CG  . ASP A 1 124 ? -15.802 20.514 71.374 1 66.512  ? 142  ASP A CG  1 
ATOM   1001 O  OD1 . ASP A 1 124 ? -16.908 20.734 71.934 1 77.528  ? 142  ASP A OD1 1 
ATOM   1002 O  OD2 . ASP A 1 124 ? -15.351 19.369 71.155 1 67.604  ? 142  ASP A OD2 1 
ATOM   1003 N  N   . LEU A 1 125 ? -17.757 22.915 68.774 1 43.456  ? 143  LEU A N   1 
ATOM   1004 C  CA  . LEU A 1 125 ? -18.546 22.521 67.612 1 43.849  ? 143  LEU A CA  1 
ATOM   1005 C  C   . LEU A 1 125 ? -18.017 23.27  66.389 1 37.705  ? 143  LEU A C   1 
ATOM   1006 O  O   . LEU A 1 125 ? -17.961 24.494 66.388 1 33.092  ? 143  LEU A O   1 
ATOM   1007 C  CB  . LEU A 1 125 ? -20.042 22.782 67.778 1 42.528  ? 143  LEU A CB  1 
ATOM   1008 C  CG  . LEU A 1 125 ? -20.796 21.807 68.684 1 47.529  ? 143  LEU A CG  1 
ATOM   1009 C  CD1 . LEU A 1 125 ? -20.48  22.027 70.159 1 46.835  ? 143  LEU A CD1 1 
ATOM   1010 C  CD2 . LEU A 1 125 ? -22.273 21.989 68.424 1 47.947  ? 143  LEU A CD2 1 
ATOM   1011 N  N   . ALA A 1 126 ? -17.634 22.516 65.36  1 35.866  ? 144  ALA A N   1 
ATOM   1012 C  CA  . ALA A 1 126 ? -17.124 23.081 64.127 1 36.273  ? 144  ALA A CA  1 
ATOM   1013 C  C   . ALA A 1 126 ? -18.224 23.045 63.075 1 34.657  ? 144  ALA A C   1 
ATOM   1014 O  O   . ALA A 1 126 ? -19.165 22.261 63.173 1 34.995  ? 144  ALA A O   1 
ATOM   1015 C  CB  . ALA A 1 126 ? -15.913 22.299 63.677 1 34.07   ? 144  ALA A CB  1 
ATOM   1016 N  N   . LEU A 1 127 ? -18.088 23.89  62.055 1 35.097  ? 145  LEU A N   1 
ATOM   1017 C  CA  . LEU A 1 127 ? -18.99  23.827 60.921 1 33.523  ? 145  LEU A CA  1 
ATOM   1018 C  C   . LEU A 1 127 ? -19.072 22.386 60.429 1 35.54   ? 145  LEU A C   1 
ATOM   1019 O  O   . LEU A 1 127 ? -20.154 21.827 60.381 1 33.916  ? 145  LEU A O   1 
ATOM   1020 C  CB  . LEU A 1 127 ? -18.509 24.761 59.826 1 32.33   ? 145  LEU A CB  1 
ATOM   1021 C  CG  . LEU A 1 127 ? -19.389 24.763 58.579 1 36.569  ? 145  LEU A CG  1 
ATOM   1022 C  CD1 . LEU A 1 127 ? -20.775 25.321 58.848 1 36.006  ? 145  LEU A CD1 1 
ATOM   1023 C  CD2 . LEU A 1 127 ? -18.653 25.565 57.549 1 40.881  ? 145  LEU A CD2 1 
ATOM   1024 N  N   . ASP A 1 128 ? -17.919 21.793 60.089 1 39.133  ? 146  ASP A N   1 
ATOM   1025 C  CA  . ASP A 1 128 ? -17.862 20.439 59.572 1 42.743  ? 146  ASP A CA  1 
ATOM   1026 C  C   . ASP A 1 128 ? -17.296 19.523 60.653 1 43.779  ? 146  ASP A C   1 
ATOM   1027 O  O   . ASP A 1 128 ? -16.104 19.604 60.959 1 44.785  ? 146  ASP A O   1 
ATOM   1028 C  CB  . ASP A 1 128 ? -17.036 20.348 58.3   1 45.023  ? 146  ASP A CB  1 
ATOM   1029 C  CG  . ASP A 1 128 ? -17.152 19.035 57.531 1 49.709  ? 146  ASP A CG  1 
ATOM   1030 O  OD1 . ASP A 1 128 ? -17.711 18.059 58.095 1 50.377  ? 146  ASP A OD1 1 
ATOM   1031 O  OD2 . ASP A 1 128 ? -16.712 19.013 56.348 1 48.161  ? 146  ASP A OD2 1 
ATOM   1032 N  N   . PRO A 1 129 ? -18.096 18.59  61.224 1 43.695  ? 147  PRO A N   1 
ATOM   1033 C  CA  . PRO A 1 129 ? -19.465 18.313 60.793 1 40.629  ? 147  PRO A CA  1 
ATOM   1034 C  C   . PRO A 1 129 ? -20.614 18.809 61.688 1 35.638  ? 147  PRO A C   1 
ATOM   1035 O  O   . PRO A 1 129 ? -21.773 18.623 61.329 1 34.399  ? 147  PRO A O   1 
ATOM   1036 C  CB  . PRO A 1 129 ? -19.461 16.782 60.862 1 45.204  ? 147  PRO A CB  1 
ATOM   1037 C  CG  . PRO A 1 129 ? -18.772 16.574 62.222 1 45.204  ? 147  PRO A CG  1 
ATOM   1038 C  CD  . PRO A 1 129 ? -17.669 17.634 62.27  1 46.728  ? 147  PRO A CD  1 
ATOM   1039 N  N   . GLU A 1 130 ? -20.329 19.382 62.864 1 35.715  ? 148  GLU A N   1 
ATOM   1040 C  CA  . GLU A 1 130 ? -21.332 19.501 63.923 1 39.379  ? 148  GLU A CA  1 
ATOM   1041 C  C   . GLU A 1 130 ? -22.443 20.518 63.611 1 40.966  ? 148  GLU A C   1 
ATOM   1042 O  O   . GLU A 1 130 ? -23.617 20.208 63.784 1 35.946  ? 148  GLU A O   1 
ATOM   1043 C  CB  . GLU A 1 130 ? -20.754 19.879 65.289 1 41.81   ? 148  GLU A CB  1 
ATOM   1044 C  CG  . GLU A 1 130 ? -19.983 18.743 65.953 1 46.731  ? 148  GLU A CG  1 
ATOM   1045 C  CD  . GLU A 1 130 ? -18.483 18.727 65.673 1 53.48   ? 148  GLU A CD  1 
ATOM   1046 O  OE1 . GLU A 1 130 ? -17.852 19.773 65.364 1 50.249  ? 148  GLU A OE1 1 
ATOM   1047 O  OE2 . GLU A 1 130 ? -17.945 17.609 65.755 1 52.269  ? 148  GLU A OE2 1 
ATOM   1048 N  N   . ILE A 1 131 ? -22.08  21.738 63.201 1 40.449  ? 149  ILE A N   1 
ATOM   1049 C  CA  . ILE A 1 131 ? -23.062 22.778 62.932 1 39.679  ? 149  ILE A CA  1 
ATOM   1050 C  C   . ILE A 1 131 ? -23.832 22.438 61.65  1 41.672  ? 149  ILE A C   1 
ATOM   1051 O  O   . ILE A 1 131 ? -25.04  22.661 61.594 1 37.606  ? 149  ILE A O   1 
ATOM   1052 C  CB  . ILE A 1 131 ? -22.401 24.164 62.844 1 37.73   ? 149  ILE A CB  1 
ATOM   1053 C  CG1 . ILE A 1 131 ? -21.665 24.565 64.137 1 40.342  ? 149  ILE A CG1 1 
ATOM   1054 C  CG2 . ILE A 1 131 ? -23.435 25.219 62.474 1 37.986  ? 149  ILE A CG2 1 
ATOM   1055 C  CD1 . ILE A 1 131 ? -20.768 25.792 63.99  1 38.968  ? 149  ILE A CD1 1 
ATOM   1056 N  N   . GLU A 1 132 ? -23.138 21.915 60.629 1 40.794  ? 150  GLU A N   1 
ATOM   1057 C  CA  . GLU A 1 132 ? -23.768 21.521 59.372 1 44.57   ? 150  GLU A CA  1 
ATOM   1058 C  C   . GLU A 1 132 ? -24.839 20.452 59.612 1 45.917  ? 150  GLU A C   1 
ATOM   1059 O  O   . GLU A 1 132 ? -25.822 20.401 58.872 1 40.988  ? 150  GLU A O   1 
ATOM   1060 C  CB  . GLU A 1 132 ? -22.797 21.003 58.305 1 45.973  ? 150  GLU A CB  1 
ATOM   1061 C  CG  . GLU A 1 132 ? -22.553 22.017 57.189 1 56.965  ? 150  GLU A CG  1 
ATOM   1062 C  CD  . GLU A 1 132 ? -21.389 21.811 56.216 1 69.028  ? 150  GLU A CD  1 
ATOM   1063 O  OE1 . GLU A 1 132 ? -20.661 20.77  56.167 1 73.482  ? 150  GLU A OE1 1 
ATOM   1064 O  OE2 . GLU A 1 132 ? -21.218 22.8   55.464 1 60.443  ? 150  GLU A OE2 1 
ATOM   1065 N  N   . GLU A 1 133 ? -24.636 19.603 60.63  1 44.353  ? 151  GLU A N   1 
ATOM   1066 C  CA  . GLU A 1 133 ? -25.564 18.527 60.945 1 50.075  ? 151  GLU A CA  1 
ATOM   1067 C  C   . GLU A 1 133 ? -26.842 19.108 61.553 1 44.624  ? 151  GLU A C   1 
ATOM   1068 O  O   . GLU A 1 133 ? -27.94  18.703 61.204 1 38.906  ? 151  GLU A O   1 
ATOM   1069 C  CB  . GLU A 1 133 ? -24.926 17.537 61.92  1 62.93   ? 151  GLU A CB  1 
ATOM   1070 C  CG  . GLU A 1 133 ? -25.61  16.172 61.961 1 76.369  ? 151  GLU A CG  1 
ATOM   1071 C  CD  . GLU A 1 133 ? -24.706 15.063 62.487 1 93.598  ? 151  GLU A CD  1 
ATOM   1072 O  OE1 . GLU A 1 133 ? -25.172 14.335 63.392 1 93.095  ? 151  GLU A OE1 1 
ATOM   1073 O  OE2 . GLU A 1 133 ? -23.543 14.923 62.011 1 94.67   ? 151  GLU A OE2 1 
ATOM   1074 N  N   . VAL A 1 134 ? -26.69  20.072 62.463 1 40.242  ? 152  VAL A N   1 
ATOM   1075 C  CA  . VAL A 1 134 ? -27.834 20.728 63.058 1 42.877  ? 152  VAL A CA  1 
ATOM   1076 C  C   . VAL A 1 134 ? -28.622 21.502 61.999 1 39.516  ? 152  VAL A C   1 
ATOM   1077 O  O   . VAL A 1 134 ? -29.828 21.353 61.919 1 38.286  ? 152  VAL A O   1 
ATOM   1078 C  CB  . VAL A 1 134 ? -27.389 21.653 64.193 1 43.86   ? 152  VAL A CB  1 
ATOM   1079 C  CG1 . VAL A 1 134 ? -28.585 22.422 64.732 1 43.72   ? 152  VAL A CG1 1 
ATOM   1080 C  CG2 . VAL A 1 134 ? -26.686 20.866 65.29  1 43.048  ? 152  VAL A CG2 1 
ATOM   1081 N  N   . ILE A 1 135 ? -27.951 22.335 61.2   1 37.621  ? 153  ILE A N   1 
ATOM   1082 C  CA  . ILE A 1 135 ? -28.63  23.129 60.186 1 36.073  ? 153  ILE A CA  1 
ATOM   1083 C  C   . ILE A 1 135 ? -29.395 22.222 59.224 1 37.29   ? 153  ILE A C   1 
ATOM   1084 O  O   . ILE A 1 135 ? -30.49  22.565 58.768 1 43.168  ? 153  ILE A O   1 
ATOM   1085 C  CB  . ILE A 1 135 ? -27.652 24.049 59.448 1 37.644  ? 153  ILE A CB  1 
ATOM   1086 C  CG1 . ILE A 1 135 ? -27.036 25.047 60.399 1 41.453  ? 153  ILE A CG1 1 
ATOM   1087 C  CG2 . ILE A 1 135 ? -28.347 24.772 58.295 1 41.616  ? 153  ILE A CG2 1 
ATOM   1088 C  CD1 . ILE A 1 135 ? -27.954 26.209 60.734 1 44.424  ? 153  ILE A CD1 1 
ATOM   1089 N  N   . SER A 1 136 ? -28.869 21.034 58.945 1 35.62   ? 154  SER A N   1 
ATOM   1090 C  CA  . SER A 1 136 ? -29.489 20.213 57.916 1 41.305  ? 154  SER A CA  1 
ATOM   1091 C  C   . SER A 1 136 ? -30.609 19.335 58.481 1 36.777  ? 154  SER A C   1 
ATOM   1092 O  O   . SER A 1 136 ? -31.484 18.911 57.727 1 40.778  ? 154  SER A O   1 
ATOM   1093 C  CB  . SER A 1 136 ? -28.448 19.403 57.183 1 41.998  ? 154  SER A CB  1 
ATOM   1094 O  OG  . SER A 1 136 ? -27.962 18.402 58.052 1 40.727  ? 154  SER A OG  1 
ATOM   1095 N  N   . LYS A 1 137 ? -30.6   19.119 59.801 1 36.185  ? 155  LYS A N   1 
ATOM   1096 C  CA  . LYS A 1 137 ? -31.44  18.121 60.447 1 42.097  ? 155  LYS A CA  1 
ATOM   1097 C  C   . LYS A 1 137 ? -32.471 18.747 61.396 1 39.349  ? 155  LYS A C   1 
ATOM   1098 O  O   . LYS A 1 137 ? -33.602 18.289 61.421 1 38.11   ? 155  LYS A O   1 
ATOM   1099 C  CB  . LYS A 1 137 ? -30.615 16.993 61.11  1 46.272  ? 155  LYS A CB  1 
ATOM   1100 C  CG  . LYS A 1 137 ? -30.101 15.943 60.097 1 65.956  ? 155  LYS A CG  1 
ATOM   1101 C  CD  . LYS A 1 137 ? -30.933 15.932 58.797 1 86.718  ? 155  LYS A CD  1 
ATOM   1102 C  CE  . LYS A 1 137 ? -30.954 14.726 57.886 1 91.534  ? 155  LYS A CE  1 
ATOM   1103 N  NZ  . LYS A 1 137 ? -29.967 14.827 56.803 1 83.519  ? 155  LYS A NZ  1 
ATOM   1104 N  N   . SER A 1 138 ? -32.102 19.752 62.197 1 36.779  ? 156  SER A N   1 
ATOM   1105 C  CA  . SER A 1 138 ? -33.034 20.32  63.159 1 38.906  ? 156  SER A CA  1 
ATOM   1106 C  C   . SER A 1 138 ? -34.158 21.08  62.455 1 36.269  ? 156  SER A C   1 
ATOM   1107 O  O   . SER A 1 138 ? -33.937 21.74  61.447 1 35.945  ? 156  SER A O   1 
ATOM   1108 C  CB  . SER A 1 138 ? -32.336 21.201 64.161 1 39.075  ? 156  SER A CB  1 
ATOM   1109 O  OG  . SER A 1 138 ? -33.233 22.113 64.774 1 39.699  ? 156  SER A OG  1 
ATOM   1110 N  N   . ARG A 1 139 ? -35.365 20.935 63.007 1 37.878  ? 157  ARG A N   1 
ATOM   1111 C  CA  . ARG A 1 139 ? -36.557 21.647 62.572 1 38.814  ? 157  ARG A CA  1 
ATOM   1112 C  C   . ARG A 1 139 ? -37.07  22.485 63.749 1 39.369  ? 157  ARG A C   1 
ATOM   1113 O  O   . ARG A 1 139 ? -38.268 22.722 63.862 1 51.206  ? 157  ARG A O   1 
ATOM   1114 C  CB  . ARG A 1 139 ? -37.587 20.63  62.065 1 39.172  ? 157  ARG A CB  1 
ATOM   1115 C  CG  . ARG A 1 139 ? -37.067 19.515 61.169 1 40.747  ? 157  ARG A CG  1 
ATOM   1116 C  CD  . ARG A 1 139 ? -36.791 20.049 59.788 1 48.755  ? 157  ARG A CD  1 
ATOM   1117 N  NE  . ARG A 1 139 ? -36.493 19.014 58.789 1 50.968  ? 157  ARG A NE  1 
ATOM   1118 C  CZ  . ARG A 1 139 ? -35.423 19.014 57.968 1 57.901  ? 157  ARG A CZ  1 
ATOM   1119 N  NH1 . ARG A 1 139 ? -34.378 19.857 58.064 1 49.441  ? 157  ARG A NH1 1 
ATOM   1120 N  NH2 . ARG A 1 139 ? -35.399 18.108 57.018 1 57.925  ? 157  ARG A NH2 1 
ATOM   1121 N  N   . ASP A 1 140 ? -36.152 22.9   64.635 1 35.127  ? 158  ASP A N   1 
ATOM   1122 C  CA  . ASP A 1 140 ? -36.42  23.866 65.687 1 37.448  ? 158  ASP A CA  1 
ATOM   1123 C  C   . ASP A 1 140 ? -35.893 25.229 65.246 1 35.487  ? 158  ASP A C   1 
ATOM   1124 O  O   . ASP A 1 140 ? -34.685 25.476 65.244 1 32.866  ? 158  ASP A O   1 
ATOM   1125 C  CB  . ASP A 1 140 ? -35.854 23.421 67.038 1 39.673  ? 158  ASP A CB  1 
ATOM   1126 C  CG  . ASP A 1 140 ? -35.839 24.471 68.152 1 47.602  ? 158  ASP A CG  1 
ATOM   1127 O  OD1 . ASP A 1 140 ? -35.755 25.688 67.842 1 61.499  ? 158  ASP A OD1 1 
ATOM   1128 O  OD2 . ASP A 1 140 ? -35.93  24.088 69.336 1 46.062  ? 158  ASP A OD2 1 
ATOM   1129 N  N   . HIS A 1 141 ? -36.81  26.145 64.928 1 35.74   ? 159  HIS A N   1 
ATOM   1130 C  CA  . HIS A 1 141 ? -36.412 27.414 64.34  1 38.074  ? 159  HIS A CA  1 
ATOM   1131 C  C   . HIS A 1 141 ? -35.532 28.238 65.292 1 38.246  ? 159  HIS A C   1 
ATOM   1132 O  O   . HIS A 1 141 ? -34.695 29.027 64.839 1 35.656  ? 159  HIS A O   1 
ATOM   1133 C  CB  . HIS A 1 141 ? -37.637 28.168 63.817 1 40.262  ? 159  HIS A CB  1 
ATOM   1134 C  CG  . HIS A 1 141 ? -38.538 28.612 64.907 1 36.225  ? 159  HIS A CG  1 
ATOM   1135 N  ND1 . HIS A 1 141 ? -39.494 27.776 65.444 1 37.746  ? 159  HIS A ND1 1 
ATOM   1136 C  CD2 . HIS A 1 141 ? -38.611 29.779 65.558 1 34.825  ? 159  HIS A CD2 1 
ATOM   1137 C  CE1 . HIS A 1 141 ? -40.112 28.425 66.409 1 36.443  ? 159  HIS A CE1 1 
ATOM   1138 N  NE2 . HIS A 1 141 ? -39.595 29.65  66.487 1 38.039  ? 159  HIS A NE2 1 
ATOM   1139 N  N   . GLU A 1 142 ? -35.679 28.06  66.611 1 37.7    ? 160  GLU A N   1 
ATOM   1140 C  CA  . GLU A 1 142 ? -34.869 28.851 67.526 1 38.368  ? 160  GLU A CA  1 
ATOM   1141 C  C   . GLU A 1 142 ? -33.436 28.314 67.635 1 34.748  ? 160  GLU A C   1 
ATOM   1142 O  O   . GLU A 1 142 ? -32.497 29.092 67.774 1 33.354  ? 160  GLU A O   1 
ATOM   1143 C  CB  . GLU A 1 142 ? -35.58  29.083 68.858 1 45.816  ? 160  GLU A CB  1 
ATOM   1144 C  CG  . GLU A 1 142 ? -36.203 30.473 68.89  1 51.574  ? 160  GLU A CG  1 
ATOM   1145 C  CD  . GLU A 1 142 ? -37.094 30.718 70.067 1 56.967  ? 160  GLU A CD  1 
ATOM   1146 O  OE1 . GLU A 1 142 ? -36.796 30.175 71.146 1 63.591  ? 160  GLU A OE1 1 
ATOM   1147 O  OE2 . GLU A 1 142 ? -38.047 31.49  69.893 1 67.733  ? 160  GLU A OE2 1 
ATOM   1148 N  N   . GLU A 1 143 ? -33.27  27     67.542 1 33.037  ? 161  GLU A N   1 
ATOM   1149 C  CA  . GLU A 1 143 ? -31.95  26.388 67.573 1 37.831  ? 161  GLU A CA  1 
ATOM   1150 C  C   . GLU A 1 143 ? -31.199 26.774 66.308 1 36.553  ? 161  GLU A C   1 
ATOM   1151 O  O   . GLU A 1 143 ? -30.062 27.239 66.367 1 36.239  ? 161  GLU A O   1 
ATOM   1152 C  CB  . GLU A 1 143 ? -32.126 24.874 67.627 1 38.514  ? 161  GLU A CB  1 
ATOM   1153 C  CG  . GLU A 1 143 ? -30.819 24.108 67.721 1 41.464  ? 161  GLU A CG  1 
ATOM   1154 C  CD  . GLU A 1 143 ? -31.06  22.616 67.788 1 42.083  ? 161  GLU A CD  1 
ATOM   1155 O  OE1 . GLU A 1 143 ? -32.086 22.102 67.285 1 43.665  ? 161  GLU A OE1 1 
ATOM   1156 O  OE2 . GLU A 1 143 ? -30.207 21.985 68.418 1 44.951  ? 161  GLU A OE2 1 
ATOM   1157 N  N   . LEU A 1 144 ? -31.896 26.606 65.179 1 34.602  ? 162  LEU A N   1 
ATOM   1158 C  CA  . LEU A 1 144 ? -31.393 26.983 63.873 1 31.544  ? 162  LEU A CA  1 
ATOM   1159 C  C   . LEU A 1 144 ? -30.868 28.41  63.881 1 29.176  ? 162  LEU A C   1 
ATOM   1160 O  O   . LEU A 1 144 ? -29.748 28.644 63.439 1 28.433  ? 162  LEU A O   1 
ATOM   1161 C  CB  . LEU A 1 144 ? -32.497 26.772 62.846 1 32.104  ? 162  LEU A CB  1 
ATOM   1162 C  CG  . LEU A 1 144 ? -32.844 25.311 62.559 1 34.672  ? 162  LEU A CG  1 
ATOM   1163 C  CD1 . LEU A 1 144 ? -34.153 25.199 61.794 1 37.966  ? 162  LEU A CD1 1 
ATOM   1164 C  CD2 . LEU A 1 144 ? -31.729 24.637 61.783 1 34.848  ? 162  LEU A CD2 1 
ATOM   1165 N  N   . ALA A 1 145 ? -31.651 29.341 64.437 1 33.416  ? 163  ALA A N   1 
ATOM   1166 C  CA  . ALA A 1 145 ? -31.304 30.76  64.419 1 33.868  ? 163  ALA A CA  1 
ATOM   1167 C  C   . ALA A 1 145 ? -30.069 30.999 65.278 1 34.524  ? 163  ALA A C   1 
ATOM   1168 O  O   . ALA A 1 145 ? -29.269 31.889 64.997 1 33.398  ? 163  ALA A O   1 
ATOM   1169 C  CB  . ALA A 1 145 ? -32.449 31.608 64.941 1 34.399  ? 163  ALA A CB  1 
ATOM   1170 N  N   . TYR A 1 146 ? -29.972 30.245 66.376 1 33.634  ? 164  TYR A N   1 
ATOM   1171 C  CA  . TYR A 1 146 ? -28.846 30.388 67.275 1 33.846  ? 164  TYR A CA  1 
ATOM   1172 C  C   . TYR A 1 146 ? -27.565 30.029 66.524 1 31.422  ? 164  TYR A C   1 
ATOM   1173 O  O   . TYR A 1 146 ? -26.604 30.78  66.567 1 32.661  ? 164  TYR A O   1 
ATOM   1174 C  CB  . TYR A 1 146 ? -29.075 29.532 68.522 1 36.247  ? 164  TYR A CB  1 
ATOM   1175 C  CG  . TYR A 1 146 ? -27.779 29.331 69.284 1 39.77   ? 164  TYR A CG  1 
ATOM   1176 C  CD1 . TYR A 1 146 ? -27.324 30.269 70.205 1 39.236  ? 164  TYR A CD1 1 
ATOM   1177 C  CD2 . TYR A 1 146 ? -26.986 28.216 69.032 1 40.634  ? 164  TYR A CD2 1 
ATOM   1178 C  CE1 . TYR A 1 146 ? -26.124 30.086 70.874 1 41.848  ? 164  TYR A CE1 1 
ATOM   1179 C  CE2 . TYR A 1 146 ? -25.792 28.019 69.699 1 41.896  ? 164  TYR A CE2 1 
ATOM   1180 C  CZ  . TYR A 1 146 ? -25.356 28.955 70.622 1 46.697  ? 164  TYR A CZ  1 
ATOM   1181 O  OH  . TYR A 1 146 ? -24.16  28.716 71.262 1 44.887  ? 164  TYR A OH  1 
ATOM   1182 N  N   . TYR A 1 147 ? -27.566 28.893 65.818 1 31.711  ? 165  TYR A N   1 
ATOM   1183 C  CA  . TYR A 1 147 ? -26.354 28.419 65.177 1 32.733  ? 165  TYR A CA  1 
ATOM   1184 C  C   . TYR A 1 147 ? -26.021 29.357 64.027 1 33.501  ? 165  TYR A C   1 
ATOM   1185 O  O   . TYR A 1 147 ? -24.852 29.633 63.784 1 31.876  ? 165  TYR A O   1 
ATOM   1186 C  CB  . TYR A 1 147 ? -26.44  26.946 64.759 1 35      ? 165  TYR A CB  1 
ATOM   1187 C  CG  . TYR A 1 147 ? -26.253 25.981 65.921 1 34.277  ? 165  TYR A CG  1 
ATOM   1188 C  CD1 . TYR A 1 147 ? -25.032 25.884 66.583 1 35.434  ? 165  TYR A CD1 1 
ATOM   1189 C  CD2 . TYR A 1 147 ? -27.306 25.19  66.38  1 37.044  ? 165  TYR A CD2 1 
ATOM   1190 C  CE1 . TYR A 1 147 ? -24.864 25.021 67.66  1 39.126  ? 165  TYR A CE1 1 
ATOM   1191 C  CE2 . TYR A 1 147 ? -27.153 24.328 67.456 1 36.585  ? 165  TYR A CE2 1 
ATOM   1192 C  CZ  . TYR A 1 147 ? -25.921 24.229 68.088 1 36.114  ? 165  TYR A CZ  1 
ATOM   1193 O  OH  . TYR A 1 147 ? -25.768 23.377 69.142 1 35.818  ? 165  TYR A OH  1 
ATOM   1194 N  N   . TRP A 1 148 ? -27.051 29.876 63.351 1 33.428  ? 166  TRP A N   1 
ATOM   1195 C  CA  . TRP A 1 148 ? -26.838 30.803 62.249 1 32.495  ? 166  TRP A CA  1 
ATOM   1196 C  C   . TRP A 1 148 ? -26.036 31.991 62.785 1 31.901  ? 166  TRP A C   1 
ATOM   1197 O  O   . TRP A 1 148 ? -24.999 32.356 62.245 1 32.897  ? 166  TRP A O   1 
ATOM   1198 C  CB  . TRP A 1 148 ? -28.184 31.22  61.611 1 30.954  ? 166  TRP A CB  1 
ATOM   1199 C  CG  . TRP A 1 148 ? -28.068 32.034 60.348 1 26.766  ? 166  TRP A CG  1 
ATOM   1200 C  CD1 . TRP A 1 148 ? -28.214 31.585 59.078 1 27.766  ? 166  TRP A CD1 1 
ATOM   1201 C  CD2 . TRP A 1 148 ? -27.755 33.435 60.226 1 25.89   ? 166  TRP A CD2 1 
ATOM   1202 N  NE1 . TRP A 1 148 ? -27.997 32.591 58.17  1 27.532  ? 166  TRP A NE1 1 
ATOM   1203 C  CE2 . TRP A 1 148 ? -27.722 33.739 58.848 1 26.81   ? 166  TRP A CE2 1 
ATOM   1204 C  CE3 . TRP A 1 148 ? -27.499 34.454 61.143 1 27.95   ? 166  TRP A CE3 1 
ATOM   1205 C  CZ2 . TRP A 1 148 ? -27.443 35.011 58.366 1 27.958  ? 166  TRP A CZ2 1 
ATOM   1206 C  CZ3 . TRP A 1 148 ? -27.222 35.721 60.677 1 29.901  ? 166  TRP A CZ3 1 
ATOM   1207 C  CH2 . TRP A 1 148 ? -27.187 35.99  59.303 1 31.866  ? 166  TRP A CH2 1 
ATOM   1208 N  N   . ARG A 1 149 ? -26.49  32.561 63.892 1 29.733  ? 167  ARG A N   1 
ATOM   1209 C  CA  . ARG A 1 149 ? -25.921 33.806 64.372 1 33.973  ? 167  ARG A CA  1 
ATOM   1210 C  C   . ARG A 1 149 ? -24.493 33.587 64.87  1 32.364  ? 167  ARG A C   1 
ATOM   1211 O  O   . ARG A 1 149 ? -23.628 34.448 64.693 1 31.006  ? 167  ARG A O   1 
ATOM   1212 C  CB  . ARG A 1 149 ? -26.808 34.392 65.479 1 36.721  ? 167  ARG A CB  1 
ATOM   1213 C  CG  . ARG A 1 149 ? -26.434 35.823 65.826 1 42.531  ? 167  ARG A CG  1 
ATOM   1214 C  CD  . ARG A 1 149 ? -26.64  36.137 67.281 1 47.874  ? 167  ARG A CD  1 
ATOM   1215 N  NE  . ARG A 1 149 ? -28.059 36.327 67.585 1 58.346  ? 167  ARG A NE  1 
ATOM   1216 C  CZ  . ARG A 1 149 ? -28.772 37.457 67.371 1 73.042  ? 167  ARG A CZ  1 
ATOM   1217 N  NH1 . ARG A 1 149 ? -28.248 38.553 66.802 1 63.705  ? 167  ARG A NH1 1 
ATOM   1218 N  NH2 . ARG A 1 149 ? -30.046 37.476 67.745 1 69.973  ? 167  ARG A NH2 1 
ATOM   1219 N  N   . GLU A 1 150 ? -24.284 32.476 65.586 1 35.99   ? 168  GLU A N   1 
ATOM   1220 C  CA  . GLU A 1 150 ? -23.002 32.189 66.202 1 37.283  ? 168  GLU A CA  1 
ATOM   1221 C  C   . GLU A 1 150 ? -21.999 32.076 65.068 1 35.784  ? 168  GLU A C   1 
ATOM   1222 O  O   . GLU A 1 150 ? -20.939 32.689 65.134 1 36.129  ? 168  GLU A O   1 
ATOM   1223 C  CB  . GLU A 1 150 ? -23.026 30.946 67.099 1 43.134  ? 168  GLU A CB  1 
ATOM   1224 C  CG  . GLU A 1 150 ? -23.718 31.18  68.447 1 46.239  ? 168  GLU A CG  1 
ATOM   1225 C  CD  . GLU A 1 150 ? -23.179 32.353 69.276 1 48.78   ? 168  GLU A CD  1 
ATOM   1226 O  OE1 . GLU A 1 150 ? -21.958 32.344 69.627 1 47.834  ? 168  GLU A OE1 1 
ATOM   1227 O  OE2 . GLU A 1 150 ? -23.969 33.298 69.565 1 43.808  ? 168  GLU A OE2 1 
ATOM   1228 N  N   . PHE A 1 151 ? -22.402 31.362 64.002 1 35.951  ? 169  PHE A N   1 
ATOM   1229 C  CA  . PHE A 1 151 ? -21.505 31.062 62.9   1 33.891  ? 169  PHE A CA  1 
ATOM   1230 C  C   . PHE A 1 151 ? -21.153 32.33  62.114 1 35.284  ? 169  PHE A C   1 
ATOM   1231 O  O   . PHE A 1 151 ? -19.98  32.562 61.794 1 36.365  ? 169  PHE A O   1 
ATOM   1232 C  CB  . PHE A 1 151 ? -22.06  29.949 62.011 1 32.392  ? 169  PHE A CB  1 
ATOM   1233 C  CG  . PHE A 1 151 ? -21.068 29.642 60.904 1 33.33   ? 169  PHE A CG  1 
ATOM   1234 C  CD1 . PHE A 1 151 ? -19.889 28.963 61.176 1 34.274  ? 169  PHE A CD1 1 
ATOM   1235 C  CD2 . PHE A 1 151 ? -21.267 30.108 59.62  1 32.478  ? 169  PHE A CD2 1 
ATOM   1236 C  CE1 . PHE A 1 151 ? -18.982 28.718 60.172 1 31.927  ? 169  PHE A CE1 1 
ATOM   1237 C  CE2 . PHE A 1 151 ? -20.35  29.859 58.627 1 31.993  ? 169  PHE A CE2 1 
ATOM   1238 C  CZ  . PHE A 1 151 ? -19.203 29.182 58.913 1 31.253  ? 169  PHE A CZ  1 
ATOM   1239 N  N   . TYR A 1 152 ? -22.156 33.169 61.825 1 31.417  ? 170  TYR A N   1 
ATOM   1240 C  CA  . TYR A 1 152 ? -21.948 34.299 60.935 1 29.585  ? 170  TYR A CA  1 
ATOM   1241 C  C   . TYR A 1 152 ? -21.091 35.336 61.643 1 30.274  ? 170  TYR A C   1 
ATOM   1242 O  O   . TYR A 1 152 ? -20.231 35.96  61.005 1 29.779  ? 170  TYR A O   1 
ATOM   1243 C  CB  . TYR A 1 152 ? -23.262 34.873 60.39  1 30.588  ? 170  TYR A CB  1 
ATOM   1244 C  CG  . TYR A 1 152 ? -23.786 34.248 59.1   1 28.234  ? 170  TYR A CG  1 
ATOM   1245 C  CD1 . TYR A 1 152 ? -24.407 33.001 59.104 1 27.517  ? 170  TYR A CD1 1 
ATOM   1246 C  CD2 . TYR A 1 152 ? -23.657 34.901 57.88  1 28.338  ? 170  TYR A CD2 1 
ATOM   1247 C  CE1 . TYR A 1 152 ? -24.875 32.417 57.94  1 26.93   ? 170  TYR A CE1 1 
ATOM   1248 C  CE2 . TYR A 1 152 ? -24.135 34.333 56.702 1 26.378  ? 170  TYR A CE2 1 
ATOM   1249 C  CZ  . TYR A 1 152 ? -24.744 33.092 56.739 1 26.563  ? 170  TYR A CZ  1 
ATOM   1250 O  OH  . TYR A 1 152 ? -25.258 32.533 55.621 1 26.344  ? 170  TYR A OH  1 
ATOM   1251 N  N   . ASP A 1 153 ? -21.299 35.483 62.961 1 33.27   ? 171  ASP A N   1 
ATOM   1252 C  CA  . ASP A 1 153 ? -20.532 36.446 63.753 1 36.823  ? 171  ASP A CA  1 
ATOM   1253 C  C   . ASP A 1 153 ? -19.04  36.071 63.752 1 35.75   ? 171  ASP A C   1 
ATOM   1254 O  O   . ASP A 1 153 ? -18.194 36.938 63.624 1 36.036  ? 171  ASP A O   1 
ATOM   1255 C  CB  . ASP A 1 153 ? -21.112 36.617 65.152 1 39.254  ? 171  ASP A CB  1 
ATOM   1256 C  CG  . ASP A 1 153 ? -22.485 37.285 65.266 1 44.714  ? 171  ASP A CG  1 
ATOM   1257 O  OD1 . ASP A 1 153 ? -22.914 37.996 64.32  1 42.044  ? 171  ASP A OD1 1 
ATOM   1258 O  OD2 . ASP A 1 153 ? -23.14  37.076 66.308 1 46.512  ? 171  ASP A OD2 1 
ATOM   1259 N  N   . LYS A 1 154 ? -18.714 34.777 63.799 1 37.281  ? 172  LYS A N   1 
ATOM   1260 C  CA  . LYS A 1 154 ? -17.336 34.336 63.926 1 39.189  ? 172  LYS A CA  1 
ATOM   1261 C  C   . LYS A 1 154 ? -16.632 34.163 62.586 1 38.801  ? 172  LYS A C   1 
ATOM   1262 O  O   . LYS A 1 154 ? -15.44  34.423 62.497 1 45.729  ? 172  LYS A O   1 
ATOM   1263 C  CB  . LYS A 1 154 ? -17.291 32.995 64.646 1 37.842  ? 172  LYS A CB  1 
ATOM   1264 C  CG  . LYS A 1 154 ? -17.532 33.209 66.104 1 40.336  ? 172  LYS A CG  1 
ATOM   1265 C  CD  . LYS A 1 154 ? -17.653 31.919 66.892 1 48.626  ? 172  LYS A CD  1 
ATOM   1266 C  CE  . LYS A 1 154 ? -18.213 32.196 68.238 1 59.7    ? 172  LYS A CE  1 
ATOM   1267 N  NZ  . LYS A 1 154 ? -17.667 31.214 69.163 1 67.115  ? 172  LYS A NZ  1 
ATOM   1268 N  N   . ALA A 1 155 ? -17.341 33.675 61.572 1 35.688  ? 173  ALA A N   1 
ATOM   1269 C  CA  . ALA A 1 155 ? -16.752 33.457 60.26  1 30.79   ? 173  ALA A CA  1 
ATOM   1270 C  C   . ALA A 1 155 ? -16.816 34.709 59.392 1 32.134  ? 173  ALA A C   1 
ATOM   1271 O  O   . ALA A 1 155 ? -16.008 34.886 58.484 1 34.208  ? 173  ALA A O   1 
ATOM   1272 C  CB  . ALA A 1 155 ? -17.478 32.328 59.583 1 30.883  ? 173  ALA A CB  1 
ATOM   1273 N  N   . GLY A 1 156 ? -17.845 35.529 59.616 1 33.08   ? 174  GLY A N   1 
ATOM   1274 C  CA  . GLY A 1 156 ? -18.05  36.721 58.818 1 33.03   ? 174  GLY A CA  1 
ATOM   1275 C  C   . GLY A 1 156 ? -17.454 37.974 59.443 1 32.277  ? 174  GLY A C   1 
ATOM   1276 O  O   . GLY A 1 156 ? -16.467 38.517 58.956 1 34.382  ? 174  GLY A O   1 
ATOM   1277 N  N   . THR A 1 157 ? -18.111 38.47  60.487 1 34.806  ? 175  THR A N   1 
ATOM   1278 C  CA  . THR A 1 157 ? -17.807 39.788 61.015 1 33.805  ? 175  THR A CA  1 
ATOM   1279 C  C   . THR A 1 157 ? -16.336 39.894 61.41  1 36.521  ? 175  THR A C   1 
ATOM   1280 O  O   . THR A 1 157 ? -15.726 40.94  61.206 1 35.448  ? 175  THR A O   1 
ATOM   1281 C  CB  . THR A 1 157 ? -18.718 40.083 62.2   1 34.68   ? 175  THR A CB  1 
ATOM   1282 O  OG1 . THR A 1 157 ? -20.037 39.906 61.696 1 29.706  ? 175  THR A OG1 1 
ATOM   1283 C  CG2 . THR A 1 157 ? -18.516 41.501 62.716 1 36.848  ? 175  THR A CG2 1 
ATOM   1284 N  N   . ALA A 1 158 ? -15.753 38.806 61.931 1 36.337  ? 176  ALA A N   1 
ATOM   1285 C  CA  . ALA A 1 158 ? -14.423 38.885 62.517 1 37.096  ? 176  ALA A CA  1 
ATOM   1286 C  C   . ALA A 1 158 ? -13.325 39.241 61.51  1 34.607  ? 176  ALA A C   1 
ATOM   1287 O  O   . ALA A 1 158 ? -12.233 39.605 61.927 1 35.38   ? 176  ALA A O   1 
ATOM   1288 C  CB  . ALA A 1 158 ? -14.092 37.592 63.191 1 37.677  ? 176  ALA A CB  1 
ATOM   1289 N  N   . VAL A 1 159 ? -13.581 39.152 60.202 1 33.063  ? 177  VAL A N   1 
ATOM   1290 C  CA  . VAL A 1 159 ? -12.524 39.354 59.219 1 31.855  ? 177  VAL A CA  1 
ATOM   1291 C  C   . VAL A 1 159 ? -12.842 40.537 58.326 1 29.538  ? 177  VAL A C   1 
ATOM   1292 O  O   . VAL A 1 159 ? -12.274 40.691 57.25  1 34.263  ? 177  VAL A O   1 
ATOM   1293 C  CB  . VAL A 1 159 ? -12.203 38.1   58.382 1 34.015  ? 177  VAL A CB  1 
ATOM   1294 C  CG1 . VAL A 1 159 ? -11.653 36.98  59.257 1 35.098  ? 177  VAL A CG1 1 
ATOM   1295 C  CG2 . VAL A 1 159 ? -13.399 37.604 57.596 1 35.92   ? 177  VAL A CG2 1 
ATOM   1296 N  N   . ARG A 1 160 ? -13.673 41.445 58.813 1 31.617  ? 178  ARG A N   1 
ATOM   1297 C  CA  . ARG A 1 160 ? -14.014 42.603 58.016 1 34.11   ? 178  ARG A CA  1 
ATOM   1298 C  C   . ARG A 1 160 ? -12.777 43.41  57.601 1 35.765  ? 178  ARG A C   1 
ATOM   1299 O  O   . ARG A 1 160 ? -12.597 43.733 56.419 1 35.782  ? 178  ARG A O   1 
ATOM   1300 C  CB  . ARG A 1 160 ? -14.996 43.471 58.798 1 38.754  ? 178  ARG A CB  1 
ATOM   1301 C  CG  . ARG A 1 160 ? -15.196 44.689 57.922 1 43.499  ? 178  ARG A CG  1 
ATOM   1302 C  CD  . ARG A 1 160 ? -16.38  45.505 58.282 1 57.668  ? 178  ARG A CD  1 
ATOM   1303 N  NE  . ARG A 1 160 ? -16.31  46.445 57.155 1 68.667  ? 178  ARG A NE  1 
ATOM   1304 C  CZ  . ARG A 1 160 ? -17.335 46.976 56.533 1 52.389  ? 178  ARG A CZ  1 
ATOM   1305 N  NH1 . ARG A 1 160 ? -17.101 47.793 55.519 1 48.765  ? 178  ARG A NH1 1 
ATOM   1306 N  NH2 . ARG A 1 160 ? -18.55  46.687 56.972 1 52.025  ? 178  ARG A NH2 1 
ATOM   1307 N  N   . SER A 1 161 ? -11.951 43.799 58.575 1 37.041  ? 179  SER A N   1 
ATOM   1308 C  CA  . SER A 1 161 ? -10.798 44.652 58.289 1 41.968  ? 179  SER A CA  1 
ATOM   1309 C  C   . SER A 1 161 ? -9.832  43.949 57.343 1 32.715  ? 179  SER A C   1 
ATOM   1310 O  O   . SER A 1 161 ? -9.235  44.603 56.503 1 31.845  ? 179  SER A O   1 
ATOM   1311 C  CB  . SER A 1 161 ? -10.082 45.139 59.546 1 43.316  ? 179  SER A CB  1 
ATOM   1312 O  OG  . SER A 1 161 ? -9.825  44.047 60.417 1 56.159  ? 179  SER A OG  1 
ATOM   1313 N  N   . GLN A 1 162 ? -9.738  42.618 57.433 1 34.882  ? 180  GLN A N   1 
ATOM   1314 C  CA  . GLN A 1 162 ? -8.893  41.85  56.529 1 34.481  ? 180  GLN A CA  1 
ATOM   1315 C  C   . GLN A 1 162 ? -9.498  41.815 55.13  1 33.554  ? 180  GLN A C   1 
ATOM   1316 O  O   . GLN A 1 162 ? -8.772  41.942 54.149 1 34.975  ? 180  GLN A O   1 
ATOM   1317 C  CB  . GLN A 1 162 ? -8.674  40.405 56.957 1 36.7    ? 180  GLN A CB  1 
ATOM   1318 C  CG  . GLN A 1 162 ? -7.673  40.248 58.09  1 42.028  ? 180  GLN A CG  1 
ATOM   1319 C  CD  . GLN A 1 162 ? -8.293  40.296 59.47  1 49.771  ? 180  GLN A CD  1 
ATOM   1320 O  OE1 . GLN A 1 162 ? -9.456  40.673 59.68  1 47.208  ? 180  GLN A OE1 1 
ATOM   1321 N  NE2 . GLN A 1 162 ? -7.487  39.906 60.444 1 59.878  ? 180  GLN A NE2 1 
ATOM   1322 N  N   . PHE A 1 163 ? -10.82  41.627 55.053 1 31.514  ? 181  PHE A N   1 
ATOM   1323 C  CA  . PHE A 1 163 ? -11.497 41.559 53.772 1 33.158  ? 181  PHE A CA  1 
ATOM   1324 C  C   . PHE A 1 163 ? -11.295 42.889 53.029 1 32.372  ? 181  PHE A C   1 
ATOM   1325 O  O   . PHE A 1 163 ? -11.003 42.923 51.836 1 34.925  ? 181  PHE A O   1 
ATOM   1326 C  CB  . PHE A 1 163 ? -12.931 41.081 54.065 1 35.484  ? 181  PHE A CB  1 
ATOM   1327 C  CG  . PHE A 1 163 ? -13.635 40.751 52.764 1 34.37   ? 181  PHE A CG  1 
ATOM   1328 C  CD1 . PHE A 1 163 ? -13.449 39.521 52.157 1 33.987  ? 181  PHE A CD1 1 
ATOM   1329 C  CD2 . PHE A 1 163 ? -14.348 41.725 52.083 1 34.838  ? 181  PHE A CD2 1 
ATOM   1330 C  CE1 . PHE A 1 163 ? -14.02  39.244 50.924 1 35.575  ? 181  PHE A CE1 1 
ATOM   1331 C  CE2 . PHE A 1 163 ? -14.916 41.445 50.863 1 36.359  ? 181  PHE A CE2 1 
ATOM   1332 C  CZ  . PHE A 1 163 ? -14.75  40.205 50.282 1 35.635  ? 181  PHE A CZ  1 
ATOM   1333 N  N   . GLU A 1 164 ? -11.375 43.998 53.748 1 34.469  ? 182  GLU A N   1 
ATOM   1334 C  CA  . GLU A 1 164 ? -11.164 45.307 53.15  1 38.115  ? 182  GLU A CA  1 
ATOM   1335 C  C   . GLU A 1 164 ? -9.776  45.437 52.543 1 34.911  ? 182  GLU A C   1 
ATOM   1336 O  O   . GLU A 1 164 ? -9.62   45.936 51.426 1 34.64   ? 182  GLU A O   1 
ATOM   1337 C  CB  . GLU A 1 164 ? -11.315 46.431 54.174 1 40.819  ? 182  GLU A CB  1 
ATOM   1338 C  CG  . GLU A 1 164 ? -12.775 46.672 54.532 1 47.129  ? 182  GLU A CG  1 
ATOM   1339 C  CD  . GLU A 1 164 ? -13.017 47.75  55.571 1 56.036  ? 182  GLU A CD  1 
ATOM   1340 O  OE1 . GLU A 1 164 ? -12.105 48.573 55.809 1 55.664  ? 182  GLU A OE1 1 
ATOM   1341 O  OE2 . GLU A 1 164 ? -14.131 47.738 56.139 1 55.817  ? 182  GLU A OE2 1 
ATOM   1342 N  N   . ARG A 1 165 ? -8.759  45.044 53.302 1 33.888  ? 183  ARG A N   1 
ATOM   1343 C  CA  . ARG A 1 165 ? -7.408  45.146 52.793 1 34.191  ? 183  ARG A CA  1 
ATOM   1344 C  C   . ARG A 1 165 ? -7.269  44.282 51.543 1 32.396  ? 183  ARG A C   1 
ATOM   1345 O  O   . ARG A 1 165 ? -6.57   44.665 50.606 1 32.603  ? 183  ARG A O   1 
ATOM   1346 C  CB  . ARG A 1 165 ? -6.334  44.802 53.833 1 39.113  ? 183  ARG A CB  1 
ATOM   1347 C  CG  . ARG A 1 165 ? -4.917  45.108 53.349 1 40.031  ? 183  ARG A CG  1 
ATOM   1348 C  CD  . ARG A 1 165 ? -4.695  46.63  53.212 1 42.35   ? 183  ARG A CD  1 
ATOM   1349 N  NE  . ARG A 1 165 ? -3.314  46.912 52.812 1 46.301  ? 183  ARG A NE  1 
ATOM   1350 C  CZ  . ARG A 1 165 ? -2.95   47.605 51.743 1 48.842  ? 183  ARG A CZ  1 
ATOM   1351 N  NH1 . ARG A 1 165 ? -3.866  48.26  51.068 1 47.59   ? 183  ARG A NH1 1 
ATOM   1352 N  NH2 . ARG A 1 165 ? -1.682  47.659 51.357 1 44.891  ? 183  ARG A NH2 1 
ATOM   1353 N  N   . TYR A 1 166 ? -7.921  43.112 51.538 1 32.972  ? 184  TYR A N   1 
ATOM   1354 C  CA  . TYR A 1 166 ? -7.88   42.216 50.389 1 29.715  ? 184  TYR A CA  1 
ATOM   1355 C  C   . TYR A 1 166 ? -8.504  42.86  49.154 1 28.888  ? 184  TYR A C   1 
ATOM   1356 O  O   . TYR A 1 166 ? -8.004  42.686 48.051 1 29.663  ? 184  TYR A O   1 
ATOM   1357 C  CB  . TYR A 1 166 ? -8.574  40.906 50.764 1 29.881  ? 184  TYR A CB  1 
ATOM   1358 C  CG  . TYR A 1 166 ? -9.286  40.154 49.639 1 30.621  ? 184  TYR A CG  1 
ATOM   1359 C  CD1 . TYR A 1 166 ? -8.59   39.475 48.635 1 29.822  ? 184  TYR A CD1 1 
ATOM   1360 C  CD2 . TYR A 1 166 ? -10.674 40.081 49.612 1 32.063  ? 184  TYR A CD2 1 
ATOM   1361 C  CE1 . TYR A 1 166 ? -9.253  38.792 47.622 1 29.16   ? 184  TYR A CE1 1 
ATOM   1362 C  CE2 . TYR A 1 166 ? -11.343 39.386 48.611 1 34.757  ? 184  TYR A CE2 1 
ATOM   1363 C  CZ  . TYR A 1 166 ? -10.635 38.712 47.636 1 30.853  ? 184  TYR A CZ  1 
ATOM   1364 O  OH  . TYR A 1 166 ? -11.366 38     46.738 1 34.138  ? 184  TYR A OH  1 
ATOM   1365 N  N   . VAL A 1 167 ? -9.625  43.573 49.31  1 31.966  ? 185  VAL A N   1 
ATOM   1366 C  CA  . VAL A 1 167 ? -10.265 44.24  48.172 1 30.54   ? 185  VAL A CA  1 
ATOM   1367 C  C   . VAL A 1 167 ? -9.335  45.285 47.564 1 29.664  ? 185  VAL A C   1 
ATOM   1368 O  O   . VAL A 1 167 ? -9.206  45.368 46.343 1 29.28   ? 185  VAL A O   1 
ATOM   1369 C  CB  . VAL A 1 167 ? -11.605 44.886 48.561 1 30.521  ? 185  VAL A CB  1 
ATOM   1370 C  CG1 . VAL A 1 167 ? -12.143 45.763 47.437 1 31.925  ? 185  VAL A CG1 1 
ATOM   1371 C  CG2 . VAL A 1 167 ? -12.624 43.822 48.952 1 32.544  ? 185  VAL A CG2 1 
ATOM   1372 N  N   . GLU A 1 168 ? -8.718  46.102 48.424 1 31.729  ? 186  GLU A N   1 
ATOM   1373 C  CA  . GLU A 1 168 ? -7.693  47.048 48.002 1 37.184  ? 186  GLU A CA  1 
ATOM   1374 C  C   . GLU A 1 168 ? -6.563  46.351 47.245 1 32.646  ? 186  GLU A C   1 
ATOM   1375 O  O   . GLU A 1 168 ? -6.156  46.805 46.176 1 30.886  ? 186  GLU A O   1 
ATOM   1376 C  CB  . GLU A 1 168 ? -7.053  47.81  49.16  1 43.089  ? 186  GLU A CB  1 
ATOM   1377 C  CG  . GLU A 1 168 ? -8.012  48.798 49.814 1 54.036  ? 186  GLU A CG  1 
ATOM   1378 C  CD  . GLU A 1 168 ? -7.596  49.352 51.171 1 62.992  ? 186  GLU A CD  1 
ATOM   1379 O  OE1 . GLU A 1 168 ? -6.422  49.245 51.608 1 55.507  ? 186  GLU A OE1 1 
ATOM   1380 O  OE2 . GLU A 1 168 ? -8.53   49.875 51.815 1 64.612  ? 186  GLU A OE2 1 
ATOM   1381 N  N   . LEU A 1 169 ? -6.026  45.265 47.791 1 29.68   ? 187  LEU A N   1 
ATOM   1382 C  CA  . LEU A 1 169 ? -4.865  44.675 47.15  1 30.088  ? 187  LEU A CA  1 
ATOM   1383 C  C   . LEU A 1 169 ? -5.253  43.943 45.88  1 28.033  ? 187  LEU A C   1 
ATOM   1384 O  O   . LEU A 1 169 ? -4.47   43.937 44.921 1 27.717  ? 187  LEU A O   1 
ATOM   1385 C  CB  . LEU A 1 169 ? -4.071  43.806 48.111 1 34.692  ? 187  LEU A CB  1 
ATOM   1386 C  CG  . LEU A 1 169 ? -3.243  44.623 49.109 1 36.083  ? 187  LEU A CG  1 
ATOM   1387 C  CD1 . LEU A 1 169 ? -2.661  43.754 50.204 1 36.613  ? 187  LEU A CD1 1 
ATOM   1388 C  CD2 . LEU A 1 169 ? -2.161  45.383 48.372 1 36.563  ? 187  LEU A CD2 1 
ATOM   1389 N  N   . ASN A 1 170 ? -6.457  43.37  45.873 1 27.841  ? 188  ASN A N   1 
ATOM   1390 C  CA  . ASN A 1 170 ? -6.951  42.687 44.694 1 30.694  ? 188  ASN A CA  1 
ATOM   1391 C  C   . ASN A 1 170 ? -7.103  43.703 43.559 1 30.232  ? 188  ASN A C   1 
ATOM   1392 O  O   . ASN A 1 170 ? -6.748  43.412 42.422 1 32.952  ? 188  ASN A O   1 
ATOM   1393 C  CB  . ASN A 1 170 ? -8.225  41.91  45.023 1 31.522  ? 188  ASN A CB  1 
ATOM   1394 C  CG  . ASN A 1 170 ? -8.905  41.35  43.797 1 30.494  ? 188  ASN A CG  1 
ATOM   1395 O  OD1 . ASN A 1 170 ? -9.418  42.123 42.984 1 29.958  ? 188  ASN A OD1 1 
ATOM   1396 N  ND2 . ASN A 1 170 ? -8.931  40.033 43.647 1 31.856  ? 188  ASN A ND2 1 
ATOM   1397 N  N   . THR A 1 171 ? -7.637  44.891 43.883 1 32.256  ? 189  THR A N   1 
ATOM   1398 C  CA  . THR A 1 171 ? -7.883  45.959 42.915 1 30.677  ? 189  THR A CA  1 
ATOM   1399 C  C   . THR A 1 171 ? -6.561  46.495 42.347 1 30.106  ? 189  THR A C   1 
ATOM   1400 O  O   . THR A 1 171 ? -6.393  46.649 41.131 1 28.122  ? 189  THR A O   1 
ATOM   1401 C  CB  . THR A 1 171 ? -8.704  47.059 43.589 1 30.14   ? 189  THR A CB  1 
ATOM   1402 O  OG1 . THR A 1 171 ? -9.963  46.53  43.982 1 28.631  ? 189  THR A OG1 1 
ATOM   1403 C  CG2 . THR A 1 171 ? -9.002  48.239 42.677 1 31.693  ? 189  THR A CG2 1 
ATOM   1404 N  N   . LYS A 1 172 ? -5.598  46.727 43.233 1 26.776  ? 190  LYS A N   1 
ATOM   1405 C  CA  . LYS A 1 172 ? -4.274  47.156 42.825 1 30.889  ? 190  LYS A CA  1 
ATOM   1406 C  C   . LYS A 1 172 ? -3.624  46.141 41.883 1 29.833  ? 190  LYS A C   1 
ATOM   1407 O  O   . LYS A 1 172 ? -3.017  46.53  40.883 1 28.406  ? 190  LYS A O   1 
ATOM   1408 C  CB  . LYS A 1 172 ? -3.442  47.403 44.087 1 39.734  ? 190  LYS A CB  1 
ATOM   1409 C  CG  . LYS A 1 172 ? -2.044  47.911 43.752 1 46.589  ? 190  LYS A CG  1 
ATOM   1410 C  CD  . LYS A 1 172 ? -1.252  48.415 44.95  1 51.622  ? 190  LYS A CD  1 
ATOM   1411 C  CE  . LYS A 1 172 ? 0.122   48.774 44.462 1 52.907  ? 190  LYS A CE  1 
ATOM   1412 N  NZ  . LYS A 1 172 ? 0.816   49.437 45.559 1 52.934  ? 190  LYS A NZ  1 
ATOM   1413 N  N   . ALA A 1 173 ? -3.767  44.849 42.196 1 27.499  ? 191  ALA A N   1 
ATOM   1414 C  CA  . ALA A 1 173 ? -3.22   43.791 41.361 1 29.412  ? 191  ALA A CA  1 
ATOM   1415 C  C   . ALA A 1 173 ? -3.848  43.811 39.975 1 28.865  ? 191  ALA A C   1 
ATOM   1416 O  O   . ALA A 1 173 ? -3.136  43.657 38.992 1 29.99   ? 191  ALA A O   1 
ATOM   1417 C  CB  . ALA A 1 173 ? -3.418  42.423 41.987 1 29.805  ? 191  ALA A CB  1 
ATOM   1418 N  N   . ALA A 1 174 ? -5.177  43.953 39.904 1 29.177  ? 192  ALA A N   1 
ATOM   1419 C  CA  . ALA A 1 174 ? -5.865  43.957 38.624 1 30.4    ? 192  ALA A CA  1 
ATOM   1420 C  C   . ALA A 1 174 ? -5.4    45.146 37.786 1 31.039  ? 192  ALA A C   1 
ATOM   1421 O  O   . ALA A 1 174 ? -5.214  45.018 36.58  1 33.827  ? 192  ALA A O   1 
ATOM   1422 C  CB  . ALA A 1 174 ? -7.37   43.995 38.837 1 31.384  ? 192  ALA A CB  1 
ATOM   1423 N  N   . LYS A 1 175 ? -5.214  46.31  38.424 1 32.275  ? 193  LYS A N   1 
ATOM   1424 C  CA  . LYS A 1 175 ? -4.857  47.514 37.682 1 32.23   ? 193  LYS A CA  1 
ATOM   1425 C  C   . LYS A 1 175 ? -3.446  47.364 37.141 1 30.494  ? 193  LYS A C   1 
ATOM   1426 O  O   . LYS A 1 175 ? -3.184  47.757 36.009 1 29.43   ? 193  LYS A O   1 
ATOM   1427 C  CB  . LYS A 1 175 ? -5.112  48.797 38.477 1 32.422  ? 193  LYS A CB  1 
ATOM   1428 C  CG  . LYS A 1 175 ? -6.591  49.105 38.685 1 33.449  ? 193  LYS A CG  1 
ATOM   1429 C  CD  . LYS A 1 175 ? -6.862  50.365 39.517 1 40.131  ? 193  LYS A CD  1 
ATOM   1430 C  CE  . LYS A 1 175 ? -8.311  50.677 39.776 1 41.013  ? 193  LYS A CE  1 
ATOM   1431 N  NZ  . LYS A 1 175 ? -9.022  50.848 38.511 1 40.831  ? 193  LYS A NZ  1 
ATOM   1432 N  N   . LEU A 1 176 ? -2.57   46.688 37.893 1 30.293  ? 194  LEU A N   1 
ATOM   1433 C  CA  . LEU A 1 176 ? -1.217  46.453 37.399 1 30.443  ? 194  LEU A CA  1 
ATOM   1434 C  C   . LEU A 1 176 ? -1.222  45.547 36.172 1 32.998  ? 194  LEU A C   1 
ATOM   1435 O  O   . LEU A 1 176 ? -0.271  45.578 35.407 1 34.301  ? 194  LEU A O   1 
ATOM   1436 C  CB  . LEU A 1 176 ? -0.309  45.921 38.511 1 31.644  ? 194  LEU A CB  1 
ATOM   1437 C  CG  . LEU A 1 176 ? 0.204   46.992 39.488 1 37.227  ? 194  LEU A CG  1 
ATOM   1438 C  CD1 . LEU A 1 176 ? 0.77    46.412 40.743 1 36.036  ? 194  LEU A CD1 1 
ATOM   1439 C  CD2 . LEU A 1 176 ? 1.261   47.936 38.843 1 36.6    ? 194  LEU A CD2 1 
ATOM   1440 N  N   . ASN A 1 177 ? -2.269  44.718 35.994 1 41.231  ? 195  ASN A N   1 
ATOM   1441 C  CA  . ASN A 1 177 ? -2.429  43.895 34.787 1 39.136  ? 195  ASN A CA  1 
ATOM   1442 C  C   . ASN A 1 177 ? -3.292  44.603 33.743 1 37.8    ? 195  ASN A C   1 
ATOM   1443 O  O   . ASN A 1 177 ? -3.616  44.011 32.71  1 34.402  ? 195  ASN A O   1 
ATOM   1444 C  CB  . ASN A 1 177 ? -3.065  42.543 35.089 1 38.064  ? 195  ASN A CB  1 
ATOM   1445 C  CG  . ASN A 1 177 ? -2.103  41.641 35.814 1 39.799  ? 195  ASN A CG  1 
ATOM   1446 O  OD1 . ASN A 1 177 ? -1.247  41.022 35.174 1 47.971  ? 195  ASN A OD1 1 
ATOM   1447 N  ND2 . ASN A 1 177 ? -2.214  41.579 37.131 1 35.129  ? 195  ASN A ND2 1 
ATOM   1448 N  N   . ASN A 1 178 ? -3.672  45.856 34.061 1 37.67   ? 196  ASN A N   1 
ATOM   1449 C  CA  . ASN A 1 178 ? -4.405  46.75  33.175 1 35.883  ? 196  ASN A CA  1 
ATOM   1450 C  C   . ASN A 1 178 ? -5.842  46.27  32.949 1 36.699  ? 196  ASN A C   1 
ATOM   1451 O  O   . ASN A 1 178 ? -6.393  46.524 31.894 1 33.271  ? 196  ASN A O   1 
ATOM   1452 C  CB  . ASN A 1 178 ? -3.671  46.972 31.856 1 34.726  ? 196  ASN A CB  1 
ATOM   1453 C  CG  . ASN A 1 178 ? -2.474  47.888 32.046 1 37.18   ? 196  ASN A CG  1 
ATOM   1454 O  OD1 . ASN A 1 178 ? -2.339  48.583 33.072 1 33.245  ? 196  ASN A OD1 1 
ATOM   1455 N  ND2 . ASN A 1 178 ? -1.618  47.926 31.044 1 37.75   ? 196  ASN A ND2 1 
ATOM   1456 N  N   . PHE A 1 179 ? -6.415  45.548 33.922 1 32.661  ? 197  PHE A N   1 
ATOM   1457 C  CA  . PHE A 1 179 ? -7.843  45.336 33.995 1 31.305  ? 197  PHE A CA  1 
ATOM   1458 C  C   . PHE A 1 179 ? -8.408  46.479 34.816 1 33.909  ? 197  PHE A C   1 
ATOM   1459 O  O   . PHE A 1 179 ? -7.676  47.06  35.609 1 34.536  ? 197  PHE A O   1 
ATOM   1460 C  CB  . PHE A 1 179 ? -8.14   44.016 34.71  1 33.393  ? 197  PHE A CB  1 
ATOM   1461 C  CG  . PHE A 1 179 ? -7.755  42.781 33.914 1 31.593  ? 197  PHE A CG  1 
ATOM   1462 C  CD1 . PHE A 1 179 ? -8.421  42.473 32.74  1 27.466  ? 197  PHE A CD1 1 
ATOM   1463 C  CD2 . PHE A 1 179 ? -6.713  41.954 34.332 1 33.039  ? 197  PHE A CD2 1 
ATOM   1464 C  CE1 . PHE A 1 179 ? -8.061  41.364 32.002 1 30.513  ? 197  PHE A CE1 1 
ATOM   1465 C  CE2 . PHE A 1 179 ? -6.346  40.844 33.574 1 33.597  ? 197  PHE A CE2 1 
ATOM   1466 C  CZ  . PHE A 1 179 ? -7.026  40.55  32.416 1 30.859  ? 197  PHE A CZ  1 
ATOM   1467 N  N   . THR A 1 180 ? -9.705  46.765 34.673 1 34.429  ? 198  THR A N   1 
ATOM   1468 C  CA  . THR A 1 180 ? -10.313 47.821 35.469 1 36.559  ? 198  THR A CA  1 
ATOM   1469 C  C   . THR A 1 180 ? -10.394 47.418 36.943 1 37.08   ? 198  THR A C   1 
ATOM   1470 O  O   . THR A 1 180 ? -10.299 48.274 37.818 1 36.392  ? 198  THR A O   1 
ATOM   1471 C  CB  . THR A 1 180 ? -11.703 48.151 34.939 1 40.813  ? 198  THR A CB  1 
ATOM   1472 O  OG1 . THR A 1 180 ? -11.462 48.367 33.561 1 40.644  ? 198  THR A OG1 1 
ATOM   1473 C  CG2 . THR A 1 180 ? -12.26  49.405 35.59  1 45.669  ? 198  THR A CG2 1 
ATOM   1474 N  N   . SER A 1 181 ? -10.653 46.131 37.21  1 34.426  ? 199  SER A N   1 
ATOM   1475 C  CA  . SER A 1 181 ? -10.85  45.661 38.566 1 34.087  ? 199  SER A CA  1 
ATOM   1476 C  C   . SER A 1 181 ? -10.669 44.154 38.586 1 33.394  ? 199  SER A C   1 
ATOM   1477 O  O   . SER A 1 181 ? -10.529 43.538 37.536 1 30.182  ? 199  SER A O   1 
ATOM   1478 C  CB  . SER A 1 181 ? -12.219 46.023 39.102 1 35.823  ? 199  SER A CB  1 
ATOM   1479 O  OG  . SER A 1 181 ? -13.241 45.16  38.616 1 34.35   ? 199  SER A OG  1 
ATOM   1480 N  N   . GLY A 1 182 ? -10.746 43.58  39.787 1 28.898  ? 200  GLY A N   1 
ATOM   1481 C  CA  . GLY A 1 182 ? -10.648 42.145 39.94  1 29.806  ? 200  GLY A CA  1 
ATOM   1482 C  C   . GLY A 1 182 ? -11.785 41.396 39.242 1 29.699  ? 200  GLY A C   1 
ATOM   1483 O  O   . GLY A 1 182 ? -11.65  40.195 39     1 37.443  ? 200  GLY A O   1 
ATOM   1484 N  N   . ALA A 1 183 ? -12.89  42.092 38.939 1 30.082  ? 201  ALA A N   1 
ATOM   1485 C  CA  . ALA A 1 183 ? -14.037 41.507 38.251 1 30.543  ? 201  ALA A CA  1 
ATOM   1486 C  C   . ALA A 1 183 ? -13.694 41.184 36.797 1 27.522  ? 201  ALA A C   1 
ATOM   1487 O  O   . ALA A 1 183 ? -14.019 40.114 36.306 1 28.243  ? 201  ALA A O   1 
ATOM   1488 C  CB  . ALA A 1 183 ? -15.234 42.437 38.335 1 29.836  ? 201  ALA A CB  1 
ATOM   1489 N  N   . GLU A 1 184 ? -13.009 42.108 36.143 1 26.842  ? 202  GLU A N   1 
ATOM   1490 C  CA  . GLU A 1 184 ? -12.545 41.945 34.782 1 30.626  ? 202  GLU A CA  1 
ATOM   1491 C  C   . GLU A 1 184 ? -11.419 40.903 34.739 1 33.314  ? 202  GLU A C   1 
ATOM   1492 O  O   . GLU A 1 184 ? -11.31  40.146 33.77  1 31.046  ? 202  GLU A O   1 
ATOM   1493 C  CB  . GLU A 1 184 ? -12.117 43.302 34.204 1 33.845  ? 202  GLU A CB  1 
ATOM   1494 C  CG  . GLU A 1 184 ? -13.255 44.304 33.961 1 37.471  ? 202  GLU A CG  1 
ATOM   1495 C  CD  . GLU A 1 184 ? -13.974 44.872 35.19  1 43.241  ? 202  GLU A CD  1 
ATOM   1496 O  OE1 . GLU A 1 184 ? -13.28  45.17  36.199 1 42.493  ? 202  GLU A OE1 1 
ATOM   1497 O  OE2 . GLU A 1 184 ? -15.222 45.029 35.15  1 43.476  ? 202  GLU A OE2 1 
ATOM   1498 N  N   . ALA A 1 185 ? -10.586 40.829 35.788 1 31.313  ? 203  ALA A N   1 
ATOM   1499 C  CA  . ALA A 1 185 ? -9.522  39.833 35.817 1 32.169  ? 203  ALA A CA  1 
ATOM   1500 C  C   . ALA A 1 185 ? -10.123 38.424 35.877 1 31.029  ? 203  ALA A C   1 
ATOM   1501 O  O   . ALA A 1 185 ? -9.775  37.56  35.081 1 32.355  ? 203  ALA A O   1 
ATOM   1502 C  CB  . ALA A 1 185 ? -8.598  40.109 36.966 1 32.64   ? 203  ALA A CB  1 
ATOM   1503 N  N   . TRP A 1 186 ? -11.112 38.228 36.75  1 29.652  ? 204  TRP A N   1 
ATOM   1504 C  CA  . TRP A 1 186 ? -11.83  36.962 36.81  1 32.745  ? 204  TRP A CA  1 
ATOM   1505 C  C   . TRP A 1 186 ? -12.539 36.61  35.506 1 34.034  ? 204  TRP A C   1 
ATOM   1506 O  O   . TRP A 1 186 ? -12.51  35.464 35.079 1 36.54   ? 204  TRP A O   1 
ATOM   1507 C  CB  . TRP A 1 186 ? -12.847 36.993 37.952 1 31.861  ? 204  TRP A CB  1 
ATOM   1508 C  CG  . TRP A 1 186 ? -12.234 36.761 39.302 1 29.98   ? 204  TRP A CG  1 
ATOM   1509 C  CD1 . TRP A 1 186 ? -10.955 36.399 39.61  1 26.319  ? 204  TRP A CD1 1 
ATOM   1510 C  CD2 . TRP A 1 186 ? -12.953 36.825 40.54  1 27.019  ? 204  TRP A CD2 1 
ATOM   1511 N  NE1 . TRP A 1 186 ? -10.834 36.254 40.968 1 29.378  ? 204  TRP A NE1 1 
ATOM   1512 C  CE2 . TRP A 1 186 ? -12.038 36.501 41.558 1 27.185  ? 204  TRP A CE2 1 
ATOM   1513 C  CE3 . TRP A 1 186 ? -14.275 37.116 40.877 1 29.017  ? 204  TRP A CE3 1 
ATOM   1514 C  CZ2 . TRP A 1 186 ? -12.413 36.479 42.894 1 28.27   ? 204  TRP A CZ2 1 
ATOM   1515 C  CZ3 . TRP A 1 186 ? -14.64  37.1   42.202 1 26.467  ? 204  TRP A CZ3 1 
ATOM   1516 C  CH2 . TRP A 1 186 ? -13.723 36.801 43.19  1 24.981  ? 204  TRP A CH2 1 
ATOM   1517 N  N   . LEU A 1 187 ? -13.21  37.598 34.907 1 34.076  ? 205  LEU A N   1 
ATOM   1518 C  CA  . LEU A 1 187 ? -14.004 37.389 33.712 1 32.349  ? 205  LEU A CA  1 
ATOM   1519 C  C   . LEU A 1 187 ? -13.125 37.077 32.51  1 30.333  ? 205  LEU A C   1 
ATOM   1520 O  O   . LEU A 1 187 ? -13.6   36.476 31.566 1 33.477  ? 205  LEU A O   1 
ATOM   1521 C  CB  . LEU A 1 187 ? -14.888 38.612 33.466 1 31.958  ? 205  LEU A CB  1 
ATOM   1522 C  CG  . LEU A 1 187 ? -16.121 38.682 34.373 1 33.372  ? 205  LEU A CG  1 
ATOM   1523 C  CD1 . LEU A 1 187 ? -16.791 40.064 34.357 1 32.511  ? 205  LEU A CD1 1 
ATOM   1524 C  CD2 . LEU A 1 187 ? -17.114 37.569 33.989 1 32.155  ? 205  LEU A CD2 1 
ATOM   1525 N  N   . ASP A 1 188 ? -11.869 37.509 32.523 1 32.581  ? 206  ASP A N   1 
ATOM   1526 C  CA  . ASP A 1 188 ? -10.966 37.242 31.424 1 33.477  ? 206  ASP A CA  1 
ATOM   1527 C  C   . ASP A 1 188 ? -10.783 35.732 31.188 1 35.864  ? 206  ASP A C   1 
ATOM   1528 O  O   . ASP A 1 188 ? -10.513 35.309 30.06  1 36.611  ? 206  ASP A O   1 
ATOM   1529 C  CB  . ASP A 1 188 ? -9.612  37.918 31.609 1 36.745  ? 206  ASP A CB  1 
ATOM   1530 C  CG  . ASP A 1 188 ? -8.74   37.892 30.347 1 41.75   ? 206  ASP A CG  1 
ATOM   1531 O  OD1 . ASP A 1 188 ? -9.21   38.408 29.296 1 43.523  ? 206  ASP A OD1 1 
ATOM   1532 O  OD2 . ASP A 1 188 ? -7.633  37.298 30.391 1 45.734  ? 206  ASP A OD2 1 
ATOM   1533 N  N   . GLU A 1 189 ? -10.933 34.92  32.239 1 35.713  ? 207  GLU A N   1 
ATOM   1534 C  CA  . GLU A 1 189 ? -10.851 33.47  32.125 1 35.964  ? 207  GLU A CA  1 
ATOM   1535 C  C   . GLU A 1 189 ? -11.92  32.869 31.196 1 35.058  ? 207  GLU A C   1 
ATOM   1536 O  O   . GLU A 1 189 ? -11.731 31.739 30.73  1 36.815  ? 207  GLU A O   1 
ATOM   1537 C  CB  . GLU A 1 189 ? -11.027 32.794 33.488 1 37.032  ? 207  GLU A CB  1 
ATOM   1538 C  CG  . GLU A 1 189 ? -10.03  33.213 34.565 1 40.876  ? 207  GLU A CG  1 
ATOM   1539 C  CD  . GLU A 1 189 ? -8.565  32.963 34.26  1 50.677  ? 207  GLU A CD  1 
ATOM   1540 O  OE1 . GLU A 1 189 ? -8.224  32.349 33.226 1 61.618  ? 207  GLU A OE1 1 
ATOM   1541 O  OE2 . GLU A 1 189 ? -7.747  33.411 35.083 1 57.146  ? 207  GLU A OE2 1 
ATOM   1542 N  N   . TYR A 1 190 ? -13.04  33.576 30.933 1 29.58   ? 208  TYR A N   1 
ATOM   1543 C  CA  . TYR A 1 190 ? -14.078 33.034 30.062 1 28.687  ? 208  TYR A CA  1 
ATOM   1544 C  C   . TYR A 1 190 ? -13.861 33.445 28.607 1 28.319  ? 208  TYR A C   1 
ATOM   1545 O  O   . TYR A 1 190 ? -14.61  33.02  27.745 1 30.05   ? 208  TYR A O   1 
ATOM   1546 C  CB  . TYR A 1 190 ? -15.463 33.397 30.593 1 27.823  ? 208  TYR A CB  1 
ATOM   1547 C  CG  . TYR A 1 190 ? -15.657 32.826 31.991 1 27.43   ? 208  TYR A CG  1 
ATOM   1548 C  CD1 . TYR A 1 190 ? -16.039 31.499 32.182 1 26.9    ? 208  TYR A CD1 1 
ATOM   1549 C  CD2 . TYR A 1 190 ? -15.389 33.596 33.109 1 27.822  ? 208  TYR A CD2 1 
ATOM   1550 C  CE1 . TYR A 1 190 ? -16.164 30.966 33.454 1 28.125  ? 208  TYR A CE1 1 
ATOM   1551 C  CE2 . TYR A 1 190 ? -15.511 33.079 34.388 1 30.023  ? 208  TYR A CE2 1 
ATOM   1552 C  CZ  . TYR A 1 190 ? -15.878 31.753 34.559 1 29.258  ? 208  TYR A CZ  1 
ATOM   1553 O  OH  . TYR A 1 190 ? -15.989 31.241 35.821 1 35.004  ? 208  TYR A OH  1 
ATOM   1554 N  N   . GLU A 1 191 ? -12.852 34.277 28.341 1 31.719  ? 209  GLU A N   1 
ATOM   1555 C  CA  . GLU A 1 191 ? -12.438 34.659 26.994 1 35.873  ? 209  GLU A CA  1 
ATOM   1556 C  C   . GLU A 1 191 ? -13.61  35.119 26.13  1 35.302  ? 209  GLU A C   1 
ATOM   1557 O  O   . GLU A 1 191 ? -13.724 34.715 24.978 1 35.605  ? 209  GLU A O   1 
ATOM   1558 C  CB  . GLU A 1 191 ? -11.694 33.534 26.272 1 36.734  ? 209  GLU A CB  1 
ATOM   1559 C  CG  . GLU A 1 191 ? -10.38  33.173 26.961 1 44.092  ? 209  GLU A CG  1 
ATOM   1560 C  CD  . GLU A 1 191 ? -9.614  32.039 26.285 1 49.652  ? 209  GLU A CD  1 
ATOM   1561 O  OE1 . GLU A 1 191 ? -9.246  32.148 25.087 1 41.387  ? 209  GLU A OE1 1 
ATOM   1562 O  OE2 . GLU A 1 191 ? -9.409  31.019 26.991 1 57.122  ? 209  GLU A OE2 1 
ATOM   1563 N  N   . ASP A 1 192 ? -14.447 36.026 26.644 1 36.335  ? 210  ASP A N   1 
ATOM   1564 C  CA  . ASP A 1 192 ? -15.631 36.44  25.897 1 36.223  ? 210  ASP A CA  1 
ATOM   1565 C  C   . ASP A 1 192 ? -16.216 37.698 26.528 1 37.291  ? 210  ASP A C   1 
ATOM   1566 O  O   . ASP A 1 192 ? -16.643 37.676 27.691 1 37.272  ? 210  ASP A O   1 
ATOM   1567 C  CB  . ASP A 1 192 ? -16.641 35.303 25.827 1 35.124  ? 210  ASP A CB  1 
ATOM   1568 C  CG  . ASP A 1 192 ? -17.877 35.564 24.985 1 38.593  ? 210  ASP A CG  1 
ATOM   1569 O  OD1 . ASP A 1 192 ? -18.137 36.753 24.66  1 42.583  ? 210  ASP A OD1 1 
ATOM   1570 O  OD2 . ASP A 1 192 ? -18.568 34.571 24.653 1 39.699  ? 210  ASP A OD2 1 
ATOM   1571 N  N   . ASP A 1 193 ? -16.229 38.785 25.741 1 42.649  ? 211  ASP A N   1 
ATOM   1572 C  CA  . ASP A 1 193 ? -16.552 40.121 26.243 1 46.659  ? 211  ASP A CA  1 
ATOM   1573 C  C   . ASP A 1 193 ? -18.054 40.287 26.529 1 41.241  ? 211  ASP A C   1 
ATOM   1574 O  O   . ASP A 1 193 ? -18.422 41.112 27.353 1 40.668  ? 211  ASP A O   1 
ATOM   1575 C  CB  . ASP A 1 193 ? -15.871 41.215 25.43  1 53.044  ? 211  ASP A CB  1 
ATOM   1576 C  CG  . ASP A 1 193 ? -16.12  41.258 23.923 1 69.436  ? 211  ASP A CG  1 
ATOM   1577 O  OD1 . ASP A 1 193 ? -16.5   40.209 23.341 1 82.919  ? 211  ASP A OD1 1 
ATOM   1578 O  OD2 . ASP A 1 193 ? -15.941 42.361 23.334 1 77.597  ? 211  ASP A OD2 1 
ATOM   1579 N  N   . THR A 1 194 ? -18.913 39.42  25.984 1 39.389  ? 212  THR A N   1 
ATOM   1580 C  CA  . THR A 1 194 ? -20.344 39.443 26.282 1 36.735  ? 212  THR A CA  1 
ATOM   1581 C  C   . THR A 1 194 ? -20.736 38.396 27.337 1 35.951  ? 212  THR A C   1 
ATOM   1582 O  O   . THR A 1 194 ? -21.903 38.049 27.46  1 35.628  ? 212  THR A O   1 
ATOM   1583 C  CB  . THR A 1 194 ? -21.089 39.19  24.97  1 39.142  ? 212  THR A CB  1 
ATOM   1584 O  OG1 . THR A 1 194 ? -20.765 37.864 24.532 1 40.991  ? 212  THR A OG1 1 
ATOM   1585 C  CG2 . THR A 1 194 ? -20.707 40.194 23.893 1 40.167  ? 212  THR A CG2 1 
ATOM   1586 N  N   . PHE A 1 195 ? -19.781 37.866 28.105 1 34.018  ? 213  PHE A N   1 
ATOM   1587 C  CA  . PHE A 1 195 ? -20.066 36.739 28.975 1 33.288  ? 213  PHE A CA  1 
ATOM   1588 C  C   . PHE A 1 195 ? -21.041 37.133 30.075 1 31.92   ? 213  PHE A C   1 
ATOM   1589 O  O   . PHE A 1 195 ? -21.886 36.322 30.435 1 35.846  ? 213  PHE A O   1 
ATOM   1590 C  CB  . PHE A 1 195 ? -18.796 36.121 29.579 1 32.676  ? 213  PHE A CB  1 
ATOM   1591 C  CG  . PHE A 1 195 ? -18.95  34.682 30.051 1 29.738  ? 213  PHE A CG  1 
ATOM   1592 C  CD1 . PHE A 1 195 ? -19.047 33.643 29.138 1 29.414  ? 213  PHE A CD1 1 
ATOM   1593 C  CD2 . PHE A 1 195 ? -18.958 34.369 31.406 1 29.518  ? 213  PHE A CD2 1 
ATOM   1594 C  CE1 . PHE A 1 195 ? -19.165 32.329 29.566 1 27.996  ? 213  PHE A CE1 1 
ATOM   1595 C  CE2 . PHE A 1 195 ? -19.077 33.062 31.834 1 28.691  ? 213  PHE A CE2 1 
ATOM   1596 C  CZ  . PHE A 1 195 ? -19.165 32.041 30.912 1 31.279  ? 213  PHE A CZ  1 
ATOM   1597 N  N   . GLU A 1 196 ? -20.898 38.324 30.656 1 34.38   ? 214  GLU A N   1 
ATOM   1598 C  CA  . GLU A 1 196 ? -21.803 38.723 31.729 1 37.189  ? 214  GLU A CA  1 
ATOM   1599 C  C   . GLU A 1 196 ? -23.232 38.797 31.215 1 32.931  ? 214  GLU A C   1 
ATOM   1600 O  O   . GLU A 1 196 ? -24.152 38.327 31.86  1 32.83   ? 214  GLU A O   1 
ATOM   1601 C  CB  . GLU A 1 196 ? -21.535 40.14  32.232 1 40.861  ? 214  GLU A CB  1 
ATOM   1602 C  CG  . GLU A 1 196 ? -20.565 40.203 33.399 1 47.203  ? 214  GLU A CG  1 
ATOM   1603 C  CD  . GLU A 1 196 ? -20.042 41.611 33.633 1 49.548  ? 214  GLU A CD  1 
ATOM   1604 O  OE1 . GLU A 1 196 ? -19.238 42.085 32.749 1 39.66   ? 214  GLU A OE1 1 
ATOM   1605 O  OE2 . GLU A 1 196 ? -20.462 42.197 34.683 1 46.378  ? 214  GLU A OE2 1 
ATOM   1606 N  N   . GLN A 1 197 ? -23.384 39.425 30.042 1 34.557  ? 215  GLN A N   1 
ATOM   1607 C  CA  . GLN A 1 197 ? -24.676 39.607 29.4   1 35.793  ? 215  GLN A CA  1 
ATOM   1608 C  C   . GLN A 1 197 ? -25.307 38.252 29.109 1 34.023  ? 215  GLN A C   1 
ATOM   1609 O  O   . GLN A 1 197 ? -26.515 38.083 29.285 1 32.622  ? 215  GLN A O   1 
ATOM   1610 C  CB  . GLN A 1 197 ? -24.591 40.429 28.108 1 36.694  ? 215  GLN A CB  1 
ATOM   1611 C  CG  . GLN A 1 197 ? -25.944 40.908 27.59  1 41.625  ? 215  GLN A CG  1 
ATOM   1612 C  CD  . GLN A 1 197 ? -26.776 41.617 28.647 1 49.01   ? 215  GLN A CD  1 
ATOM   1613 O  OE1 . GLN A 1 197 ? -26.334 42.604 29.248 1 49.165  ? 215  GLN A OE1 1 
ATOM   1614 N  NE2 . GLN A 1 197 ? -27.964 41.093 28.938 1 45.812  ? 215  GLN A NE2 1 
ATOM   1615 N  N   . GLN A 1 198 ? -24.475 37.289 28.684 1 33.864  ? 216  GLN A N   1 
ATOM   1616 C  CA  . GLN A 1 198 ? -24.956 35.962 28.323 1 32.631  ? 216  GLN A CA  1 
ATOM   1617 C  C   . GLN A 1 198 ? -25.567 35.266 29.528 1 32.012  ? 216  GLN A C   1 
ATOM   1618 O  O   . GLN A 1 198 ? -26.629 34.662 29.408 1 32.863  ? 216  GLN A O   1 
ATOM   1619 C  CB  . GLN A 1 198 ? -23.836 35.09  27.772 1 31.89   ? 216  GLN A CB  1 
ATOM   1620 C  CG  . GLN A 1 198 ? -23.497 35.346 26.306 1 31.679  ? 216  GLN A CG  1 
ATOM   1621 C  CD  . GLN A 1 198 ? -22.36  34.449 25.864 1 35.616  ? 216  GLN A CD  1 
ATOM   1622 O  OE1 . GLN A 1 198 ? -22.403 33.218 26.018 1 35.678  ? 216  GLN A OE1 1 
ATOM   1623 N  NE2 . GLN A 1 198 ? -21.281 35.068 25.411 1 36.777  ? 216  GLN A NE2 1 
ATOM   1624 N  N   . LEU A 1 199 ? -24.909 35.411 30.69  1 33.2    ? 217  LEU A N   1 
ATOM   1625 C  CA  . LEU A 1 199 ? -25.395 34.819 31.926 1 34.025  ? 217  LEU A CA  1 
ATOM   1626 C  C   . LEU A 1 199 ? -26.671 35.516 32.381 1 32.712  ? 217  LEU A C   1 
ATOM   1627 O  O   . LEU A 1 199 ? -27.577 34.825 32.819 1 31.997  ? 217  LEU A O   1 
ATOM   1628 C  CB  . LEU A 1 199 ? -24.317 34.863 33.006 1 34.639  ? 217  LEU A CB  1 
ATOM   1629 C  CG  . LEU A 1 199 ? -23.145 33.915 32.792 1 33.019  ? 217  LEU A CG  1 
ATOM   1630 C  CD1 . LEU A 1 199 ? -22.06  34.245 33.77  1 34.516  ? 217  LEU A CD1 1 
ATOM   1631 C  CD2 . LEU A 1 199 ? -23.623 32.486 32.95  1 34.503  ? 217  LEU A CD2 1 
ATOM   1632 N  N   . GLU A 1 200 ? -26.75  36.854 32.257 1 33.676  ? 218  GLU A N   1 
ATOM   1633 C  CA  . GLU A 1 200 ? -27.977 37.583 32.578 1 35.433  ? 218  GLU A CA  1 
ATOM   1634 C  C   . GLU A 1 200 ? -29.182 37.054 31.801 1 33.875  ? 218  GLU A C   1 
ATOM   1635 O  O   . GLU A 1 200 ? -30.262 36.872 32.359 1 33.437  ? 218  GLU A O   1 
ATOM   1636 C  CB  . GLU A 1 200 ? -27.914 39.056 32.184 1 39.821  ? 218  GLU A CB  1 
ATOM   1637 C  CG  . GLU A 1 200 ? -26.875 39.85  32.966 1 44.281  ? 218  GLU A CG  1 
ATOM   1638 C  CD  . GLU A 1 200 ? -27.262 40.131 34.403 1 49.884  ? 218  GLU A CD  1 
ATOM   1639 O  OE1 . GLU A 1 200 ? -28.348 39.66  34.851 1 57.149  ? 218  GLU A OE1 1 
ATOM   1640 O  OE2 . GLU A 1 200 ? -26.468 40.854 35.055 1 50.509  ? 218  GLU A OE2 1 
ATOM   1641 N  N   . ASP A 1 201 ? -28.986 36.815 30.499 1 37.505  ? 219  ASP A N   1 
ATOM   1642 C  CA  . ASP A 1 201 ? -30.032 36.325 29.609 1 36.412  ? 219  ASP A CA  1 
ATOM   1643 C  C   . ASP A 1 201 ? -30.489 34.926 30.029 1 35.958  ? 219  ASP A C   1 
ATOM   1644 O  O   . ASP A 1 201 ? -31.683 34.691 30.163 1 37.797  ? 219  ASP A O   1 
ATOM   1645 C  CB  . ASP A 1 201 ? -29.568 36.321 28.157 1 38.701  ? 219  ASP A CB  1 
ATOM   1646 C  CG  . ASP A 1 201 ? -29.384 37.683 27.494 1 48.032  ? 219  ASP A CG  1 
ATOM   1647 O  OD1 . ASP A 1 201 ? -29.707 38.708 28.145 1 47.647  ? 219  ASP A OD1 1 
ATOM   1648 O  OD2 . ASP A 1 201 ? -28.893 37.711 26.332 1 61.713  ? 219  ASP A OD2 1 
ATOM   1649 N  N   . ILE A 1 202 ? -29.544 33.997 30.222 1 33.102  ? 220  ILE A N   1 
ATOM   1650 C  CA  . ILE A 1 202 ? -29.873 32.677 30.737 1 35.667  ? 220  ILE A CA  1 
ATOM   1651 C  C   . ILE A 1 202 ? -30.555 32.778 32.105 1 37.715  ? 220  ILE A C   1 
ATOM   1652 O  O   . ILE A 1 202 ? -31.556 32.109 32.335 1 36.855  ? 220  ILE A O   1 
ATOM   1653 C  CB  . ILE A 1 202 ? -28.631 31.764 30.766 1 34.64   ? 220  ILE A CB  1 
ATOM   1654 C  CG1 . ILE A 1 202 ? -28.215 31.402 29.353 1 33.314  ? 220  ILE A CG1 1 
ATOM   1655 C  CG2 . ILE A 1 202 ? -28.866 30.507 31.601 1 33.162  ? 220  ILE A CG2 1 
ATOM   1656 C  CD1 . ILE A 1 202 ? -26.771 30.986 29.238 1 36.758  ? 220  ILE A CD1 1 
ATOM   1657 N  N   . PHE A 1 203 ? -30.038 33.605 33.021 1 36.351  ? 221  PHE A N   1 
ATOM   1658 C  CA  . PHE A 1 203 ? -30.644 33.666 34.347 1 34.754  ? 221  PHE A CA  1 
ATOM   1659 C  C   . PHE A 1 203 ? -32.095 34.167 34.229 1 32.882  ? 221  PHE A C   1 
ATOM   1660 O  O   . PHE A 1 203 ? -32.997 33.627 34.859 1 29.522  ? 221  PHE A O   1 
ATOM   1661 C  CB  . PHE A 1 203 ? -29.777 34.492 35.309 1 34.962  ? 221  PHE A CB  1 
ATOM   1662 C  CG  . PHE A 1 203 ? -30.457 34.635 36.66  1 36.996  ? 221  PHE A CG  1 
ATOM   1663 C  CD1 . PHE A 1 203 ? -30.559 33.545 37.518 1 39.886  ? 221  PHE A CD1 1 
ATOM   1664 C  CD2 . PHE A 1 203 ? -31.05  35.833 37.036 1 38.607  ? 221  PHE A CD2 1 
ATOM   1665 C  CE1 . PHE A 1 203 ? -31.232 33.649 38.722 1 44.963  ? 221  PHE A CE1 1 
ATOM   1666 C  CE2 . PHE A 1 203 ? -31.733 35.928 38.232 1 42.386  ? 221  PHE A CE2 1 
ATOM   1667 C  CZ  . PHE A 1 203 ? -31.819 34.834 39.079 1 44.286  ? 221  PHE A CZ  1 
ATOM   1668 N  N   . ALA A 1 204 ? -32.342 35.176 33.394 1 32.493  ? 222  ALA A N   1 
ATOM   1669 C  CA  . ALA A 1 204 ? -33.686 35.723 33.238 1 34.033  ? 222  ALA A CA  1 
ATOM   1670 C  C   . ALA A 1 204 ? -34.69  34.684 32.723 1 34.507  ? 222  ALA A C   1 
ATOM   1671 O  O   . ALA A 1 204 ? -35.846 34.714 33.132 1 35.171  ? 222  ALA A O   1 
ATOM   1672 C  CB  . ALA A 1 204 ? -33.646 36.948 32.346 1 33.145  ? 222  ALA A CB  1 
ATOM   1673 N  N   . ASP A 1 205 ? -34.253 33.729 31.888 1 35.541  ? 223  ASP A N   1 
ATOM   1674 C  CA  . ASP A 1 205 ? -35.121 32.657 31.389 1 38.304  ? 223  ASP A CA  1 
ATOM   1675 C  C   . ASP A 1 205 ? -35.48  31.605 32.441 1 38.024  ? 223  ASP A C   1 
ATOM   1676 O  O   . ASP A 1 205 ? -36.554 31.013 32.361 1 40.43   ? 223  ASP A O   1 
ATOM   1677 C  CB  . ASP A 1 205 ? -34.522 31.91  30.208 1 42.171  ? 223  ASP A CB  1 
ATOM   1678 C  CG  . ASP A 1 205 ? -34.371 32.719 28.919 1 50.416  ? 223  ASP A CG  1 
ATOM   1679 O  OD1 . ASP A 1 205 ? -35.182 33.656 28.703 1 44.331  ? 223  ASP A OD1 1 
ATOM   1680 O  OD2 . ASP A 1 205 ? -33.406 32.443 28.15  1 54.154  ? 223  ASP A OD2 1 
ATOM   1681 N  N   . ILE A 1 206 ? -34.608 31.36  33.42  1 34.182  ? 224  ILE A N   1 
ATOM   1682 C  CA  . ILE A 1 206 ? -34.853 30.349 34.44  1 36.427  ? 224  ILE A CA  1 
ATOM   1683 C  C   . ILE A 1 206 ? -35.462 30.972 35.697 1 31.667  ? 224  ILE A C   1 
ATOM   1684 O  O   . ILE A 1 206 ? -36.057 30.281 36.515 1 29.097  ? 224  ILE A O   1 
ATOM   1685 C  CB  . ILE A 1 206 ? -33.528 29.629 34.755 1 42.472  ? 224  ILE A CB  1 
ATOM   1686 C  CG1 . ILE A 1 206 ? -33.01  28.947 33.532 1 48.943  ? 224  ILE A CG1 1 
ATOM   1687 C  CG2 . ILE A 1 206 ? -33.676 28.626 35.887 1 40.715  ? 224  ILE A CG2 1 
ATOM   1688 C  CD1 . ILE A 1 206 ? -31.51  28.768 33.557 1 55.785  ? 224  ILE A CD1 1 
ATOM   1689 N  N   . ARG A 1 207 ? -35.316 32.285 35.874 1 34.396  ? 225  ARG A N   1 
ATOM   1690 C  CA  . ARG A 1 207 ? -35.857 32.96  37.051 1 35.984  ? 225  ARG A CA  1 
ATOM   1691 C  C   . ARG A 1 207 ? -37.333 32.616 37.306 1 33.789  ? 225  ARG A C   1 
ATOM   1692 O  O   . ARG A 1 207 ? -37.688 32.311 38.434 1 34.167  ? 225  ARG A O   1 
ATOM   1693 C  CB  . ARG A 1 207 ? -35.577 34.451 36.88  1 39.447  ? 225  ARG A CB  1 
ATOM   1694 C  CG  . ARG A 1 207 ? -35.867 35.259 38.131 1 50.011  ? 225  ARG A CG  1 
ATOM   1695 C  CD  . ARG A 1 207 ? -35.231 36.632 38.008 1 57.214  ? 225  ARG A CD  1 
ATOM   1696 N  NE  . ARG A 1 207 ? -35.053 37.259 39.325 1 67.05   ? 225  ARG A NE  1 
ATOM   1697 C  CZ  . ARG A 1 207 ? -34.421 38.414 39.568 1 63.594  ? 225  ARG A CZ  1 
ATOM   1698 N  NH1 . ARG A 1 207 ? -33.824 39.076 38.584 1 55.76   ? 225  ARG A NH1 1 
ATOM   1699 N  NH2 . ARG A 1 207 ? -34.387 38.896 40.806 1 60.557  ? 225  ARG A NH2 1 
ATOM   1700 N  N   . PRO A 1 208 ? -38.254 32.606 36.31  1 31.523  ? 226  PRO A N   1 
ATOM   1701 C  CA  . PRO A 1 208 ? -39.66  32.302 36.573 1 33.869  ? 226  PRO A CA  1 
ATOM   1702 C  C   . PRO A 1 208 ? -39.898 30.953 37.243 1 32.776  ? 226  PRO A C   1 
ATOM   1703 O  O   . PRO A 1 208 ? -40.704 30.834 38.173 1 30.966  ? 226  PRO A O   1 
ATOM   1704 C  CB  . PRO A 1 208 ? -40.314 32.418 35.188 1 33.732  ? 226  PRO A CB  1 
ATOM   1705 C  CG  . PRO A 1 208 ? -39.415 33.419 34.462 1 31.375  ? 226  PRO A CG  1 
ATOM   1706 C  CD  . PRO A 1 208 ? -38.029 33.005 34.909 1 32.587  ? 226  PRO A CD  1 
ATOM   1707 N  N   . LEU A 1 209 ? -39.143 29.948 36.8   1 31.835  ? 227  LEU A N   1 
ATOM   1708 C  CA  . LEU A 1 209 ? -39.178 28.653 37.451 1 30.062  ? 227  LEU A CA  1 
ATOM   1709 C  C   . LEU A 1 209 ? -38.699 28.775 38.901 1 30.281  ? 227  LEU A C   1 
ATOM   1710 O  O   . LEU A 1 209 ? -39.299 28.171 39.803 1 26.095  ? 227  LEU A O   1 
ATOM   1711 C  CB  . LEU A 1 209 ? -38.326 27.679 36.654 1 32.551  ? 227  LEU A CB  1 
ATOM   1712 C  CG  . LEU A 1 209 ? -38.198 26.276 37.241 1 37.589  ? 227  LEU A CG  1 
ATOM   1713 C  CD1 . LEU A 1 209 ? -39.543 25.673 37.576 1 35.218  ? 227  LEU A CD1 1 
ATOM   1714 C  CD2 . LEU A 1 209 ? -37.447 25.455 36.218 1 43.483  ? 227  LEU A CD2 1 
ATOM   1715 N  N   . TYR A 1 210 ? -37.617 29.551 39.117 1 28.918  ? 228  TYR A N   1 
ATOM   1716 C  CA  . TYR A 1 210 ? -37.067 29.725 40.453 1 28.795  ? 228  TYR A CA  1 
ATOM   1717 C  C   . TYR A 1 210 ? -38.141 30.308 41.368 1 29.225  ? 228  TYR A C   1 
ATOM   1718 O  O   . TYR A 1 210 ? -38.348 29.812 42.478 1 29.99   ? 228  TYR A O   1 
ATOM   1719 C  CB  . TYR A 1 210 ? -35.815 30.604 40.559 1 28.23   ? 228  TYR A CB  1 
ATOM   1720 C  CG  . TYR A 1 210 ? -35.43  30.846 42.014 1 27.935  ? 228  TYR A CG  1 
ATOM   1721 C  CD1 . TYR A 1 210 ? -34.938 29.815 42.8   1 28.32   ? 228  TYR A CD1 1 
ATOM   1722 C  CD2 . TYR A 1 210 ? -35.611 32.079 42.619 1 26.31   ? 228  TYR A CD2 1 
ATOM   1723 C  CE1 . TYR A 1 210 ? -34.631 30.011 44.134 1 30.843  ? 228  TYR A CE1 1 
ATOM   1724 C  CE2 . TYR A 1 210 ? -35.297 32.287 43.95  1 25.649  ? 228  TYR A CE2 1 
ATOM   1725 C  CZ  . TYR A 1 210 ? -34.781 31.26  44.704 1 27.72   ? 228  TYR A CZ  1 
ATOM   1726 O  OH  . TYR A 1 210 ? -34.41  31.452 46     1 29.497  ? 228  TYR A OH  1 
ATOM   1727 N  N   . GLN A 1 211 ? -38.866 31.32  40.879 1 29.271  ? 229  GLN A N   1 
ATOM   1728 C  CA  . GLN A 1 211 ? -39.878 31.99  41.696 1 32.215  ? 229  GLN A CA  1 
ATOM   1729 C  C   . GLN A 1 211 ? -41.026 31.039 42.037 1 29.456  ? 229  GLN A C   1 
ATOM   1730 O  O   . GLN A 1 211 ? -41.615 31.141 43.119 1 28.736  ? 229  GLN A O   1 
ATOM   1731 C  CB  . GLN A 1 211 ? -40.472 33.201 40.986 1 37.705  ? 229  GLN A CB  1 
ATOM   1732 C  CG  . GLN A 1 211 ? -39.437 34.124 40.359 1 45.663  ? 229  GLN A CG  1 
ATOM   1733 C  CD  . GLN A 1 211 ? -39.39  35.505 40.96  1 53.614  ? 229  GLN A CD  1 
ATOM   1734 O  OE1 . GLN A 1 211 ? -38.445 35.868 41.662 1 71.62   ? 229  GLN A OE1 1 
ATOM   1735 N  NE2 . GLN A 1 211 ? -40.412 36.29  40.673 1 51.659  ? 229  GLN A NE2 1 
ATOM   1736 N  N   . GLN A 1 212 ? -41.35  30.12  41.114 1 25.219  ? 230  GLN A N   1 
ATOM   1737 C  CA  . GLN A 1 212 ? -42.4   29.142 41.365 1 26.702  ? 230  GLN A CA  1 
ATOM   1738 C  C   . GLN A 1 212 ? -41.982 28.175 42.472 1 27.381  ? 230  GLN A C   1 
ATOM   1739 O  O   . GLN A 1 212 ? -42.804 27.804 43.32  1 26.932  ? 230  GLN A O   1 
ATOM   1740 C  CB  . GLN A 1 212 ? -42.746 28.385 40.08  1 27.664  ? 230  GLN A CB  1 
ATOM   1741 C  CG  . GLN A 1 212 ? -43.298 29.268 38.97  1 26.712  ? 230  GLN A CG  1 
ATOM   1742 C  CD  . GLN A 1 212 ? -44.716 29.725 39.255 1 28.745  ? 230  GLN A CD  1 
ATOM   1743 O  OE1 . GLN A 1 212 ? -45.576 28.945 39.672 1 31.132  ? 230  GLN A OE1 1 
ATOM   1744 N  NE2 . GLN A 1 212 ? -44.956 31.007 39.069 1 26.569  ? 230  GLN A NE2 1 
ATOM   1745 N  N   . ILE A 1 213 ? -40.706 27.747 42.433 1 27.612  ? 231  ILE A N   1 
ATOM   1746 C  CA  . ILE A 1 213 ? -40.155 26.841 43.428 1 28.223  ? 231  ILE A CA  1 
ATOM   1747 C  C   . ILE A 1 213 ? -40.126 27.549 44.779 1 26.084  ? 231  ILE A C   1 
ATOM   1748 O  O   . ILE A 1 213 ? -40.486 26.969 45.79  1 28.108  ? 231  ILE A O   1 
ATOM   1749 C  CB  . ILE A 1 213 ? -38.755 26.333 43.019 1 29.019  ? 231  ILE A CB  1 
ATOM   1750 C  CG1 . ILE A 1 213 ? -38.818 25.376 41.838 1 34.166  ? 231  ILE A CG1 1 
ATOM   1751 C  CG2 . ILE A 1 213 ? -38.048 25.674 44.194 1 28.234  ? 231  ILE A CG2 1 
ATOM   1752 C  CD1 . ILE A 1 213 ? -37.501 25.211 41.075 1 34.906  ? 231  ILE A CD1 1 
ATOM   1753 N  N   . HIS A 1 214 ? -39.601 28.774 44.782 1 29.097  ? 232  HIS A N   1 
ATOM   1754 C  CA  . HIS A 1 214 ? -39.574 29.63  45.96  1 32.125  ? 232  HIS A CA  1 
ATOM   1755 C  C   . HIS A 1 214 ? -40.968 29.731 46.584 1 29.414  ? 232  HIS A C   1 
ATOM   1756 O  O   . HIS A 1 214 ? -41.135 29.479 47.779 1 27.159  ? 232  HIS A O   1 
ATOM   1757 C  CB  . HIS A 1 214 ? -39.02  31.008 45.578 1 32.519  ? 232  HIS A CB  1 
ATOM   1758 C  CG  . HIS A 1 214 ? -38.979 32.003 46.694 1 33.6    ? 232  HIS A CG  1 
ATOM   1759 N  ND1 . HIS A 1 214 ? -40.099 32.633 47.181 1 32.137  ? 232  HIS A ND1 1 
ATOM   1760 C  CD2 . HIS A 1 214 ? -37.954 32.474 47.395 1 31.947  ? 232  HIS A CD2 1 
ATOM   1761 C  CE1 . HIS A 1 214 ? -39.74  33.428 48.17  1 34.542  ? 232  HIS A CE1 1 
ATOM   1762 N  NE2 . HIS A 1 214 ? -38.439 33.373 48.295 1 32.427  ? 232  HIS A NE2 1 
ATOM   1763 N  N   . GLY A 1 215 ? -41.963 30.119 45.776 1 29.774  ? 233  GLY A N   1 
ATOM   1764 C  CA  . GLY A 1 215 ? -43.334 30.293 46.263 1 29.066  ? 233  GLY A CA  1 
ATOM   1765 C  C   . GLY A 1 215 ? -43.891 29.038 46.935 1 30.305  ? 233  GLY A C   1 
ATOM   1766 O  O   . GLY A 1 215 ? -44.456 29.102 48.03  1 28.938  ? 233  GLY A O   1 
ATOM   1767 N  N   . TYR A 1 216 ? -43.685 27.882 46.284 1 32.55   ? 234  TYR A N   1 
ATOM   1768 C  CA  . TYR A 1 216 ? -44.179 26.611 46.783 1 30.618  ? 234  TYR A CA  1 
ATOM   1769 C  C   . TYR A 1 216 ? -43.475 26.221 48.079 1 32.704  ? 234  TYR A C   1 
ATOM   1770 O  O   . TYR A 1 216 ? -44.106 25.684 48.997 1 29.285  ? 234  TYR A O   1 
ATOM   1771 C  CB  . TYR A 1 216 ? -43.998 25.5   45.744 1 33.065  ? 234  TYR A CB  1 
ATOM   1772 C  CG  . TYR A 1 216 ? -44.657 24.199 46.179 1 34.128  ? 234  TYR A CG  1 
ATOM   1773 C  CD1 . TYR A 1 216 ? -46.025 24.02  46.06  1 36.445  ? 234  TYR A CD1 1 
ATOM   1774 C  CD2 . TYR A 1 216 ? -43.917 23.166 46.723 1 33.373  ? 234  TYR A CD2 1 
ATOM   1775 C  CE1 . TYR A 1 216 ? -46.642 22.856 46.487 1 37.998  ? 234  TYR A CE1 1 
ATOM   1776 C  CE2 . TYR A 1 216 ? -44.519 21.994 47.145 1 37.381  ? 234  TYR A CE2 1 
ATOM   1777 C  CZ  . TYR A 1 216 ? -45.886 21.838 47.029 1 39.994  ? 234  TYR A CZ  1 
ATOM   1778 O  OH  . TYR A 1 216 ? -46.481 20.692 47.458 1 42.609  ? 234  TYR A OH  1 
ATOM   1779 N  N   . VAL A 1 217 ? -42.153 26.449 48.141 1 31.145  ? 235  VAL A N   1 
ATOM   1780 C  CA  . VAL A 1 217 ? -41.395 26.086 49.332 1 30.386  ? 235  VAL A CA  1 
ATOM   1781 C  C   . VAL A 1 217 ? -41.867 26.917 50.523 1 26.884  ? 235  VAL A C   1 
ATOM   1782 O  O   . VAL A 1 217 ? -42.053 26.397 51.611 1 28.993  ? 235  VAL A O   1 
ATOM   1783 C  CB  . VAL A 1 217 ? -39.882 26.227 49.063 1 27.529  ? 235  VAL A CB  1 
ATOM   1784 C  CG1 . VAL A 1 217 ? -39.062 26.288 50.341 1 28.501  ? 235  VAL A CG1 1 
ATOM   1785 C  CG2 . VAL A 1 217 ? -39.406 25.078 48.205 1 26.331  ? 235  VAL A CG2 1 
ATOM   1786 N  N   . ARG A 1 218 ? -42.057 28.215 50.295 1 28.33   ? 236  ARG A N   1 
ATOM   1787 C  CA  . ARG A 1 218 ? -42.57  29.127 51.305 1 28.819  ? 236  ARG A CA  1 
ATOM   1788 C  C   . ARG A 1 218 ? -43.941 28.685 51.811 1 28.585  ? 236  ARG A C   1 
ATOM   1789 O  O   . ARG A 1 218 ? -44.175 28.655 53.023 1 29.502  ? 236  ARG A O   1 
ATOM   1790 C  CB  . ARG A 1 218 ? -42.589 30.548 50.745 1 28.314  ? 236  ARG A CB  1 
ATOM   1791 C  CG  . ARG A 1 218 ? -43.162 31.569 51.716 1 28.258  ? 236  ARG A CG  1 
ATOM   1792 C  CD  . ARG A 1 218 ? -43.03  32.968 51.144 1 27.997  ? 236  ARG A CD  1 
ATOM   1793 N  NE  . ARG A 1 218 ? -43.596 33.161 49.806 1 27.381  ? 236  ARG A NE  1 
ATOM   1794 C  CZ  . ARG A 1 218 ? -43.419 34.26  49.07  1 27.273  ? 236  ARG A CZ  1 
ATOM   1795 N  NH1 . ARG A 1 218 ? -42.677 35.249 49.526 1 27.346  ? 236  ARG A NH1 1 
ATOM   1796 N  NH2 . ARG A 1 218 ? -43.932 34.352 47.854 1 28.283  ? 236  ARG A NH2 1 
ATOM   1797 N  N   . PHE A 1 219 ? -44.838 28.323 50.896 1 29.788  ? 237  PHE A N   1 
ATOM   1798 C  CA  . PHE A 1 219 ? -46.137 27.76  51.26  1 30.763  ? 237  PHE A CA  1 
ATOM   1799 C  C   . PHE A 1 219 ? -45.98  26.534 52.168 1 30.425  ? 237  PHE A C   1 
ATOM   1800 O  O   . PHE A 1 219 ? -46.553 26.474 53.265 1 30.682  ? 237  PHE A O   1 
ATOM   1801 C  CB  . PHE A 1 219 ? -46.903 27.535 49.951 1 35.325  ? 237  PHE A CB  1 
ATOM   1802 C  CG  . PHE A 1 219 ? -48.067 26.563 50.071 1 36.006  ? 237  PHE A CG  1 
ATOM   1803 C  CD1 . PHE A 1 219 ? -49.262 26.958 50.645 1 34.916  ? 237  PHE A CD1 1 
ATOM   1804 C  CD2 . PHE A 1 219 ? -47.967 25.273 49.563 1 36.808  ? 237  PHE A CD2 1 
ATOM   1805 C  CE1 . PHE A 1 219 ? -50.321 26.071 50.745 1 35.539  ? 237  PHE A CE1 1 
ATOM   1806 C  CE2 . PHE A 1 219 ? -49.033 24.39  49.66  1 41.487  ? 237  PHE A CE2 1 
ATOM   1807 C  CZ  . PHE A 1 219 ? -50.202 24.791 50.27  1 38.52   ? 237  PHE A CZ  1 
ATOM   1808 N  N   . ARG A 1 220 ? -45.128 25.576 51.782 1 28.14   ? 238  ARG A N   1 
ATOM   1809 C  CA  . ARG A 1 220 ? -44.973 24.383 52.593 1 29.364  ? 238  ARG A CA  1 
ATOM   1810 C  C   . ARG A 1 220 ? -44.332 24.697 53.95  1 30.506  ? 238  ARG A C   1 
ATOM   1811 O  O   . ARG A 1 220 ? -44.662 24.041 54.93  1 33.677  ? 238  ARG A O   1 
ATOM   1812 C  CB  . ARG A 1 220 ? -44.226 23.303 51.793 1 32.778  ? 238  ARG A CB  1 
ATOM   1813 C  CG  . ARG A 1 220 ? -44.963 22.83  50.548 1 33.016  ? 238  ARG A CG  1 
ATOM   1814 C  CD  . ARG A 1 220 ? -46.227 22.09  50.942 1 36.675  ? 238  ARG A CD  1 
ATOM   1815 N  NE  . ARG A 1 220 ? -45.922 20.877 51.713 1 36.742  ? 238  ARG A NE  1 
ATOM   1816 C  CZ  . ARG A 1 220 ? -45.569 19.739 51.125 1 40.661  ? 238  ARG A CZ  1 
ATOM   1817 N  NH1 . ARG A 1 220 ? -45.696 19.618 49.817 1 45.469  ? 238  ARG A NH1 1 
ATOM   1818 N  NH2 . ARG A 1 220 ? -45.076 18.733 51.82  1 42.029  ? 238  ARG A NH2 1 
ATOM   1819 N  N   . LEU A 1 221 ? -43.376 25.635 54.013 1 30.652  ? 239  LEU A N   1 
ATOM   1820 C  CA  . LEU A 1 221 ? -42.725 25.999 55.268 1 33.23   ? 239  LEU A CA  1 
ATOM   1821 C  C   . LEU A 1 221 ? -43.715 26.623 56.25  1 32.267  ? 239  LEU A C   1 
ATOM   1822 O  O   . LEU A 1 221 ? -43.598 26.401 57.453 1 31.302  ? 239  LEU A O   1 
ATOM   1823 C  CB  . LEU A 1 221 ? -41.558 26.957 54.993 1 33.819  ? 239  LEU A CB  1 
ATOM   1824 C  CG  . LEU A 1 221 ? -40.309 26.294 54.402 1 33.375  ? 239  LEU A CG  1 
ATOM   1825 C  CD1 . LEU A 1 221 ? -39.236 27.309 54.084 1 34.388  ? 239  LEU A CD1 1 
ATOM   1826 C  CD2 . LEU A 1 221 ? -39.786 25.223 55.346 1 30.508  ? 239  LEU A CD2 1 
ATOM   1827 N  N   . ARG A 1 222 ? -44.664 27.414 55.722 1 31.624  ? 240  ARG A N   1 
ATOM   1828 C  CA  . ARG A 1 222 ? -45.726 28.019 56.518 1 33.498  ? 240  ARG A CA  1 
ATOM   1829 C  C   . ARG A 1 222 ? -46.57  26.959 57.209 1 32.777  ? 240  ARG A C   1 
ATOM   1830 O  O   . ARG A 1 222 ? -46.932 27.127 58.356 1 38.467  ? 240  ARG A O   1 
ATOM   1831 C  CB  . ARG A 1 222 ? -46.66  28.93  55.717 1 32.722  ? 240  ARG A CB  1 
ATOM   1832 C  CG  . ARG A 1 222 ? -45.967 30.206 55.271 1 34.375  ? 240  ARG A CG  1 
ATOM   1833 C  CD  . ARG A 1 222 ? -46.756 31.001 54.241 1 37.289  ? 240  ARG A CD  1 
ATOM   1834 N  NE  . ARG A 1 222 ? -48.04  31.38  54.841 1 41.968  ? 240  ARG A NE  1 
ATOM   1835 C  CZ  . ARG A 1 222 ? -49.237 31.401 54.255 1 40.665  ? 240  ARG A CZ  1 
ATOM   1836 N  NH1 . ARG A 1 222 ? -49.387 31.172 52.956 1 39.912  ? 240  ARG A NH1 1 
ATOM   1837 N  NH2 . ARG A 1 222 ? -50.285 31.691 54.993 1 37.305  ? 240  ARG A NH2 1 
ATOM   1838 N  N   . LYS A 1 223 ? -46.841 25.853 56.539 1 33.411  ? 241  LYS A N   1 
ATOM   1839 C  CA  . LYS A 1 223 ? -47.618 24.776 57.132 1 35.476  ? 241  LYS A CA  1 
ATOM   1840 C  C   . LYS A 1 223 ? -46.813 24.052 58.202 1 36.562  ? 241  LYS A C   1 
ATOM   1841 O  O   . LYS A 1 223 ? -47.395 23.51  59.138 1 38.59   ? 241  LYS A O   1 
ATOM   1842 C  CB  . LYS A 1 223 ? -48.105 23.796 56.064 1 39      ? 241  LYS A CB  1 
ATOM   1843 C  CG  . LYS A 1 223 ? -48.894 24.507 54.951 1 50.39   ? 241  LYS A CG  1 
ATOM   1844 C  CD  . LYS A 1 223 ? -49.372 23.649 53.79  1 62.928  ? 241  LYS A CD  1 
ATOM   1845 C  CE  . LYS A 1 223 ? -50.338 22.619 54.264 1 73.365  ? 241  LYS A CE  1 
ATOM   1846 N  NZ  . LYS A 1 223 ? -50.863 21.878 53.118 1 82.754  ? 241  LYS A NZ  1 
ATOM   1847 N  N   . HIS A 1 224 ? -45.478 24.03  58.074 1 34.499  ? 242  HIS A N   1 
ATOM   1848 C  CA  . HIS A 1 224 ? -44.661 23.328 59.054 1 31.442  ? 242  HIS A CA  1 
ATOM   1849 C  C   . HIS A 1 224 ? -44.409 24.219 60.268 1 30.927  ? 242  HIS A C   1 
ATOM   1850 O  O   . HIS A 1 224 ? -44.648 23.818 61.404 1 33.335  ? 242  HIS A O   1 
ATOM   1851 C  CB  . HIS A 1 224 ? -43.376 22.819 58.409 1 33.246  ? 242  HIS A CB  1 
ATOM   1852 C  CG  . HIS A 1 224 ? -42.538 21.985 59.311 1 36.541  ? 242  HIS A CG  1 
ATOM   1853 N  ND1 . HIS A 1 224 ? -42.542 20.599 59.296 1 35.444  ? 242  HIS A ND1 1 
ATOM   1854 C  CD2 . HIS A 1 224 ? -41.648 22.364 60.251 1 38.115  ? 242  HIS A CD2 1 
ATOM   1855 C  CE1 . HIS A 1 224 ? -41.701 20.157 60.223 1 38.937  ? 242  HIS A CE1 1 
ATOM   1856 N  NE2 . HIS A 1 224 ? -41.124 21.21  60.803 1 40.465  ? 242  HIS A NE2 1 
ATOM   1857 N  N   . TYR A 1 225 ? -43.938 25.44  60.033 1 32.686  ? 243  TYR A N   1 
ATOM   1858 C  CA  . TYR A 1 225 ? -43.494 26.292 61.125 1 37.813  ? 243  TYR A CA  1 
ATOM   1859 C  C   . TYR A 1 225 ? -44.594 27.247 61.61  1 37.938  ? 243  TYR A C   1 
ATOM   1860 O  O   . TYR A 1 225 ? -44.489 27.785 62.713 1 35.187  ? 243  TYR A O   1 
ATOM   1861 C  CB  . TYR A 1 225 ? -42.241 27.012 60.624 1 36.203  ? 243  TYR A CB  1 
ATOM   1862 C  CG  . TYR A 1 225 ? -40.977 26.17  60.556 1 33.529  ? 243  TYR A CG  1 
ATOM   1863 C  CD1 . TYR A 1 225 ? -40.288 25.837 61.709 1 32.433  ? 243  TYR A CD1 1 
ATOM   1864 C  CD2 . TYR A 1 225 ? -40.424 25.789 59.337 1 35.473  ? 243  TYR A CD2 1 
ATOM   1865 C  CE1 . TYR A 1 225 ? -39.132 25.073 61.655 1 34.276  ? 243  TYR A CE1 1 
ATOM   1866 C  CE2 . TYR A 1 225 ? -39.255 25.042 59.266 1 32.078  ? 243  TYR A CE2 1 
ATOM   1867 C  CZ  . TYR A 1 225 ? -38.608 24.689 60.434 1 33.593  ? 243  TYR A CZ  1 
ATOM   1868 O  OH  . TYR A 1 225 ? -37.455 23.964 60.411 1 37.483  ? 243  TYR A OH  1 
ATOM   1869 N  N   . GLY A 1 226 ? -45.618 27.471 60.772 1 35.593  ? 244  GLY A N   1 
ATOM   1870 C  CA  . GLY A 1 226 ? -46.689 28.419 61.054 1 35.724  ? 244  GLY A CA  1 
ATOM   1871 C  C   . GLY A 1 226 ? -46.323 29.845 60.663 1 33.498  ? 244  GLY A C   1 
ATOM   1872 O  O   . GLY A 1 226 ? -45.164 30.128 60.405 1 34.794  ? 244  GLY A O   1 
ATOM   1873 N  N   . ASP A 1 227 ? -47.312 30.753 60.715 1 39.113  ? 245  ASP A N   1 
ATOM   1874 C  CA  . ASP A 1 227 ? -47.225 32.071 60.092 1 37.644  ? 245  ASP A CA  1 
ATOM   1875 C  C   . ASP A 1 227 ? -46.485 33.066 60.967 1 34.769  ? 245  ASP A C   1 
ATOM   1876 O  O   . ASP A 1 227 ? -46.05  34.086 60.472 1 37.292  ? 245  ASP A O   1 
ATOM   1877 C  CB  . ASP A 1 227 ? -48.584 32.594 59.667 1 40.168  ? 245  ASP A CB  1 
ATOM   1878 C  CG  . ASP A 1 227 ? -49.206 31.785 58.538 1 43.687  ? 245  ASP A CG  1 
ATOM   1879 O  OD1 . ASP A 1 227 ? -49.628 30.638 58.8   1 50.429  ? 245  ASP A OD1 1 
ATOM   1880 O  OD2 . ASP A 1 227 ? -49.191 32.273 57.405 1 40.878  ? 245  ASP A OD2 1 
ATOM   1881 N  N   . ALA A 1 228 ? -46.285 32.739 62.239 1 34.175  ? 246  ALA A N   1 
ATOM   1882 C  CA  . ALA A 1 228 ? -45.432 33.541 63.091 1 32.246  ? 246  ALA A CA  1 
ATOM   1883 C  C   . ALA A 1 228 ? -43.966 33.473 62.65  1 33.053  ? 246  ALA A C   1 
ATOM   1884 O  O   . ALA A 1 228 ? -43.235 34.44  62.838 1 30.832  ? 246  ALA A O   1 
ATOM   1885 C  CB  . ALA A 1 228 ? -45.61  33.101 64.543 1 33.608  ? 246  ALA A CB  1 
ATOM   1886 N  N   . VAL A 1 229 ? -43.533 32.337 62.079 1 34.376  ? 247  VAL A N   1 
ATOM   1887 C  CA  . VAL A 1 229 ? -42.138 32.139 61.698 1 32.186  ? 247  VAL A CA  1 
ATOM   1888 C  C   . VAL A 1 229 ? -41.886 32.498 60.237 1 31.012  ? 247  VAL A C   1 
ATOM   1889 O  O   . VAL A 1 229 ? -40.805 32.999 59.945 1 32.184  ? 247  VAL A O   1 
ATOM   1890 C  CB  . VAL A 1 229 ? -41.719 30.68  61.952 1 33.063  ? 247  VAL A CB  1 
ATOM   1891 C  CG1 . VAL A 1 229 ? -40.264 30.435 61.559 1 34.943  ? 247  VAL A CG1 1 
ATOM   1892 C  CG2 . VAL A 1 229 ? -41.955 30.288 63.394 1 31.048  ? 247  VAL A CG2 1 
ATOM   1893 N  N   . VAL A 1 230 ? -42.843 32.182 59.339 1 30.723  ? 248  VAL A N   1 
ATOM   1894 C  CA  . VAL A 1 230 ? -42.729 32.413 57.896 1 32.834  ? 248  VAL A CA  1 
ATOM   1895 C  C   . VAL A 1 230 ? -43.919 33.237 57.405 1 35.852  ? 248  VAL A C   1 
ATOM   1896 O  O   . VAL A 1 230 ? -45.055 32.78  57.495 1 39.34   ? 248  VAL A O   1 
ATOM   1897 C  CB  . VAL A 1 230 ? -42.744 31.046 57.173 1 33.668  ? 248  VAL A CB  1 
ATOM   1898 C  CG1 . VAL A 1 230 ? -42.554 31.161 55.667 1 33.78   ? 248  VAL A CG1 1 
ATOM   1899 C  CG2 . VAL A 1 230 ? -41.742 30.086 57.782 1 33.32   ? 248  VAL A CG2 1 
ATOM   1900 N  N   . SER A 1 231 ? -43.679 34.409 56.822 1 35.424  ? 249  SER A N   1 
ATOM   1901 C  CA  . SER A 1 231 ? -44.769 35.179 56.24  1 37.922  ? 249  SER A CA  1 
ATOM   1902 C  C   . SER A 1 231 ? -45.11  34.644 54.856 1 35.934  ? 249  SER A C   1 
ATOM   1903 O  O   . SER A 1 231 ? -44.286 34.006 54.223 1 37.728  ? 249  SER A O   1 
ATOM   1904 C  CB  . SER A 1 231 ? -44.457 36.654 56.172 1 38.183  ? 249  SER A CB  1 
ATOM   1905 O  OG  . SER A 1 231 ? -43.552 36.934 55.117 1 40.631  ? 249  SER A OG  1 
ATOM   1906 N  N   . GLU A 1 232 ? -46.327 34.95  54.395 1 37.099  ? 250  GLU A N   1 
ATOM   1907 C  CA  . GLU A 1 232 ? -46.773 34.61  53.053 1 33.67   ? 250  GLU A CA  1 
ATOM   1908 C  C   . GLU A 1 232 ? -46.055 35.456 52.01  1 29.735  ? 250  GLU A C   1 
ATOM   1909 O  O   . GLU A 1 232 ? -45.795 34.991 50.907 1 34.9    ? 250  GLU A O   1 
ATOM   1910 C  CB  . GLU A 1 232 ? -48.287 34.807 52.935 1 35.783  ? 250  GLU A CB  1 
ATOM   1911 C  CG  . GLU A 1 232 ? -48.854 34.41  51.572 1 43.317  ? 250  GLU A CG  1 
ATOM   1912 C  CD  . GLU A 1 232 ? -50.367 34.514 51.361 1 49.791  ? 250  GLU A CD  1 
ATOM   1913 O  OE1 . GLU A 1 232 ? -50.982 35.252 52.16  1 53.831  ? 250  GLU A OE1 1 
ATOM   1914 O  OE2 . GLU A 1 232 ? -50.932 33.858 50.428 1 46.906  ? 250  GLU A OE2 1 
ATOM   1915 N  N   . THR A 1 233 ? -45.804 36.726 52.313 1 28.15   ? 251  THR A N   1 
ATOM   1916 C  CA  . THR A 1 233 ? -45.471 37.675 51.267 1 30.236  ? 251  THR A CA  1 
ATOM   1917 C  C   . THR A 1 233 ? -44.022 38.128 51.358 1 27.824  ? 251  THR A C   1 
ATOM   1918 O  O   . THR A 1 233 ? -43.548 38.825 50.473 1 32.185  ? 251  THR A O   1 
ATOM   1919 C  CB  . THR A 1 233 ? -46.412 38.884 51.331 1 35.507  ? 251  THR A CB  1 
ATOM   1920 O  OG1 . THR A 1 233 ? -46.22  39.48  52.61  1 34.977  ? 251  THR A OG1 1 
ATOM   1921 C  CG2 . THR A 1 233 ? -47.857 38.492 51.082 1 34.132  ? 251  THR A CG2 1 
ATOM   1922 N  N   . GLY A 1 234 ? -43.326 37.783 52.433 1 28.162  ? 252  GLY A N   1 
ATOM   1923 C  CA  . GLY A 1 234 ? -41.96  38.248 52.616 1 30.099  ? 252  GLY A CA  1 
ATOM   1924 C  C   . GLY A 1 234 ? -40.927 37.208 52.173 1 27.625  ? 252  GLY A C   1 
ATOM   1925 O  O   . GLY A 1 234 ? -41.278 36.047 51.931 1 27.491  ? 252  GLY A O   1 
ATOM   1926 N  N   . PRO A 1 235 ? -39.626 37.585 52.145 1 25.18   ? 253  PRO A N   1 
ATOM   1927 C  CA  . PRO A 1 235 ? -38.551 36.641 51.884 1 24.935  ? 253  PRO A CA  1 
ATOM   1928 C  C   . PRO A 1 235 ? -38.53  35.52  52.908 1 28.377  ? 253  PRO A C   1 
ATOM   1929 O  O   . PRO A 1 235 ? -38.927 35.711 54.054 1 30.163  ? 253  PRO A O   1 
ATOM   1930 C  CB  . PRO A 1 235 ? -37.286 37.48  52     1 24.331  ? 253  PRO A CB  1 
ATOM   1931 C  CG  . PRO A 1 235 ? -37.751 38.904 51.845 1 24.692  ? 253  PRO A CG  1 
ATOM   1932 C  CD  . PRO A 1 235 ? -39.115 38.927 52.466 1 24.843  ? 253  PRO A CD  1 
ATOM   1933 N  N   . ILE A 1 236 ? -38.04  34.355 52.491 1 31.235  ? 254  ILE A N   1 
ATOM   1934 C  CA  . ILE A 1 236 ? -38.008 33.199 53.365 1 29.766  ? 254  ILE A CA  1 
ATOM   1935 C  C   . ILE A 1 236 ? -36.86  33.413 54.352 1 30.84   ? 254  ILE A C   1 
ATOM   1936 O  O   . ILE A 1 236 ? -35.759 33.777 53.925 1 26.934  ? 254  ILE A O   1 
ATOM   1937 C  CB  . ILE A 1 236 ? -37.818 31.885 52.577 1 30.707  ? 254  ILE A CB  1 
ATOM   1938 C  CG1 . ILE A 1 236 ? -38.838 31.699 51.437 1 29.466  ? 254  ILE A CG1 1 
ATOM   1939 C  CG2 . ILE A 1 236 ? -37.846 30.725 53.558 1 30.859  ? 254  ILE A CG2 1 
ATOM   1940 C  CD1 . ILE A 1 236 ? -38.618 30.458 50.592 1 28.179  ? 254  ILE A CD1 1 
ATOM   1941 N  N   . PRO A 1 237 ? -37.082 33.194 55.676 1 32.25   ? 255  PRO A N   1 
ATOM   1942 C  CA  . PRO A 1 237 ? -35.992 33.149 56.644 1 32.185  ? 255  PRO A CA  1 
ATOM   1943 C  C   . PRO A 1 237 ? -35.019 32.009 56.337 1 30.098  ? 255  PRO A C   1 
ATOM   1944 O  O   . PRO A 1 237 ? -35.397 30.847 56.331 1 29.102  ? 255  PRO A O   1 
ATOM   1945 C  CB  . PRO A 1 237 ? -36.699 32.972 58.005 1 32.673  ? 255  PRO A CB  1 
ATOM   1946 C  CG  . PRO A 1 237 ? -38.137 33.372 57.725 1 33.204  ? 255  PRO A CG  1 
ATOM   1947 C  CD  . PRO A 1 237 ? -38.378 32.921 56.31  1 32.761  ? 255  PRO A CD  1 
ATOM   1948 N  N   . MET A 1 238 ? -33.758 32.357 56.09  1 30.656  ? 256  MET A N   1 
ATOM   1949 C  CA  . MET A 1 238 ? -32.841 31.47  55.393 1 30.01   ? 256  MET A CA  1 
ATOM   1950 C  C   . MET A 1 238 ? -32.425 30.282 56.255 1 28.59   ? 256  MET A C   1 
ATOM   1951 O  O   . MET A 1 238 ? -32.006 29.252 55.739 1 29.34   ? 256  MET A O   1 
ATOM   1952 C  CB  . MET A 1 238 ? -31.619 32.252 54.914 1 29.519  ? 256  MET A CB  1 
ATOM   1953 C  CG  . MET A 1 238 ? -30.761 32.801 56.01  1 28.587  ? 256  MET A CG  1 
ATOM   1954 S  SD  . MET A 1 238 ? -29.432 33.761 55.264 1 30.525  ? 256  MET A SD  1 
ATOM   1955 C  CE  . MET A 1 238 ? -28.545 32.565 54.257 1 31.916  ? 256  MET A CE  1 
ATOM   1956 N  N   . HIS A 1 239 ? -32.569 30.418 57.568 1 28.982  ? 257  HIS A N   1 
ATOM   1957 C  CA  . HIS A 1 239 ? -32.108 29.395 58.484 1 30.591  ? 257  HIS A CA  1 
ATOM   1958 C  C   . HIS A 1 239 ? -32.986 28.155 58.46  1 30.165  ? 257  HIS A C   1 
ATOM   1959 O  O   . HIS A 1 239 ? -32.636 27.154 59.078 1 30.721  ? 257  HIS A O   1 
ATOM   1960 C  CB  . HIS A 1 239 ? -32.002 29.957 59.903 1 33.519  ? 257  HIS A CB  1 
ATOM   1961 C  CG  . HIS A 1 239 ? -33.271 30.36  60.533 1 33.508  ? 257  HIS A CG  1 
ATOM   1962 N  ND1 . HIS A 1 239 ? -34.155 31.216 59.928 1 35.264  ? 257  HIS A ND1 1 
ATOM   1963 C  CD2 . HIS A 1 239 ? -33.765 30.097 61.75  1 36.79   ? 257  HIS A CD2 1 
ATOM   1964 C  CE1 . HIS A 1 239 ? -35.175 31.423 60.754 1 37.899  ? 257  HIS A CE1 1 
ATOM   1965 N  NE2 . HIS A 1 239 ? -34.968 30.757 61.863 1 34.721  ? 257  HIS A NE2 1 
ATOM   1966 N  N   . LEU A 1 240 ? -34.112 28.231 57.751 1 29.481  ? 258  LEU A N   1 
ATOM   1967 C  CA  . LEU A 1 240 ? -35.062 27.14  57.692 1 30.868  ? 258  LEU A CA  1 
ATOM   1968 C  C   . LEU A 1 240 ? -34.855 26.296 56.452 1 29.964  ? 258  LEU A C   1 
ATOM   1969 O  O   . LEU A 1 240 ? -35.679 25.422 56.202 1 29.135  ? 258  LEU A O   1 
ATOM   1970 C  CB  . LEU A 1 240 ? -36.475 27.716 57.616 1 34.109  ? 258  LEU A CB  1 
ATOM   1971 C  CG  . LEU A 1 240 ? -36.864 28.727 58.69  1 36.395  ? 258  LEU A CG  1 
ATOM   1972 C  CD1 . LEU A 1 240 ? -38.297 29.093 58.41  1 37.411  ? 258  LEU A CD1 1 
ATOM   1973 C  CD2 . LEU A 1 240 ? -36.696 28.187 60.094 1 35.071  ? 258  LEU A CD2 1 
ATOM   1974 N  N   . LEU A 1 241 ? -33.862 26.641 55.618 1 31.626  ? 259  LEU A N   1 
ATOM   1975 C  CA  . LEU A 1 241 ? -33.758 26.042 54.29  1 31.758  ? 259  LEU A CA  1 
ATOM   1976 C  C   . LEU A 1 241 ? -32.741 24.886 54.196 1 31.432  ? 259  LEU A C   1 
ATOM   1977 O  O   . LEU A 1 241 ? -32.44  24.442 53.095 1 31.128  ? 259  LEU A O   1 
ATOM   1978 C  CB  . LEU A 1 241 ? -33.445 27.186 53.33  1 30.227  ? 259  LEU A CB  1 
ATOM   1979 C  CG  . LEU A 1 241 ? -34.612 28.122 53.008 1 29.563  ? 259  LEU A CG  1 
ATOM   1980 C  CD1 . LEU A 1 241 ? -34.161 29.262 52.104 1 30.487  ? 259  LEU A CD1 1 
ATOM   1981 C  CD2 . LEU A 1 241 ? -35.747 27.333 52.366 1 30.22   ? 259  LEU A CD2 1 
ATOM   1982 N  N   . GLY A 1 242 ? -32.215 24.385 55.326 1 32.856  ? 260  GLY A N   1 
ATOM   1983 C  CA  . GLY A 1 242 ? -31.415 23.154 55.369 1 33.696  ? 260  GLY A CA  1 
ATOM   1984 C  C   . GLY A 1 242 ? -29.907 23.348 55.117 1 34.79   ? 260  GLY A C   1 
ATOM   1985 O  O   . GLY A 1 242 ? -29.157 22.378 55.003 1 32.787  ? 260  GLY A O   1 
ATOM   1986 N  N   . ASN A 1 243 ? -29.456 24.605 55.033 1 30.676  ? 261  ASN A N   1 
ATOM   1987 C  CA  . ASN A 1 243 ? -28.113 24.925 54.604 1 29.631  ? 261  ASN A CA  1 
ATOM   1988 C  C   . ASN A 1 243 ? -27.753 26.302 55.155 1 29.967  ? 261  ASN A C   1 
ATOM   1989 O  O   . ASN A 1 243 ? -28.552 27.228 55.1   1 30.418  ? 261  ASN A O   1 
ATOM   1990 C  CB  . ASN A 1 243 ? -28.03  24.873 53.085 1 29.64   ? 261  ASN A CB  1 
ATOM   1991 C  CG  . ASN A 1 243 ? -26.665 25.253 52.573 1 31.668  ? 261  ASN A CG  1 
ATOM   1992 O  OD1 . ASN A 1 243 ? -26.393 26.421 52.27  1 34.951  ? 261  ASN A OD1 1 
ATOM   1993 N  ND2 . ASN A 1 243 ? -25.77  24.291 52.512 1 35.544  ? 261  ASN A ND2 1 
ATOM   1994 N  N   . MET A 1 244 ? -26.523 26.445 55.633 1 30.122  ? 262  MET A N   1 
ATOM   1995 C  CA  . MET A 1 244 ? -26.074 27.629 56.346 1 29.919  ? 262  MET A CA  1 
ATOM   1996 C  C   . MET A 1 244 ? -26.108 28.891 55.462 1 29.741  ? 262  MET A C   1 
ATOM   1997 O  O   . MET A 1 244 ? -26.185 30.013 55.982 1 27.013  ? 262  MET A O   1 
ATOM   1998 C  CB  . MET A 1 244 ? -24.637 27.357 56.828 1 31.157  ? 262  MET A CB  1 
ATOM   1999 C  CG  . MET A 1 244 ? -23.986 28.509 57.548 1 30.727  ? 262  MET A CG  1 
ATOM   2000 S  SD  . MET A 1 244 ? -24.92  28.858 59.049 1 34.283  ? 262  MET A SD  1 
ATOM   2001 C  CE  . MET A 1 244 ? -24.256 27.552 60.091 1 35.24   ? 262  MET A CE  1 
ATOM   2002 N  N   . TRP A 1 245 ? -25.962 28.73  54.134 1 27.495  ? 263  TRP A N   1 
ATOM   2003 C  CA  . TRP A 1 245 ? -26.025 29.849 53.203 1 27.56   ? 263  TRP A CA  1 
ATOM   2004 C  C   . TRP A 1 245 ? -27.27  29.819 52.301 1 29.55   ? 263  TRP A C   1 
ATOM   2005 O  O   . TRP A 1 245 ? -27.392 30.638 51.377 1 27.275  ? 263  TRP A O   1 
ATOM   2006 C  CB  . TRP A 1 245 ? -24.739 29.849 52.37  1 30.73   ? 263  TRP A CB  1 
ATOM   2007 C  CG  . TRP A 1 245 ? -23.532 29.685 53.247 1 30.893  ? 263  TRP A CG  1 
ATOM   2008 C  CD1 . TRP A 1 245 ? -22.867 30.654 53.928 1 32.548  ? 263  TRP A CD1 1 
ATOM   2009 C  CD2 . TRP A 1 245 ? -22.914 28.443 53.602 1 31.057  ? 263  TRP A CD2 1 
ATOM   2010 N  NE1 . TRP A 1 245 ? -21.878 30.096 54.688 1 32.292  ? 263  TRP A NE1 1 
ATOM   2011 C  CE2 . TRP A 1 245 ? -21.884 28.746 54.512 1 31.619  ? 263  TRP A CE2 1 
ATOM   2012 C  CE3 . TRP A 1 245 ? -23.129 27.116 53.238 1 34.247  ? 263  TRP A CE3 1 
ATOM   2013 C  CZ2 . TRP A 1 245 ? -21.071 27.764 55.067 1 34.291  ? 263  TRP A CZ2 1 
ATOM   2014 C  CZ3 . TRP A 1 245 ? -22.324 26.14  53.79  1 34.816  ? 263  TRP A CZ3 1 
ATOM   2015 C  CH2 . TRP A 1 245 ? -21.333 26.462 54.715 1 34.551  ? 263  TRP A CH2 1 
ATOM   2016 N  N   . ALA A 1 246 ? -28.18  28.869 52.584 1 27.996  ? 264  ALA A N   1 
ATOM   2017 C  CA  . ALA A 1 246 ? -29.371 28.601 51.799 1 28.801  ? 264  ALA A CA  1 
ATOM   2018 C  C   . ALA A 1 246 ? -29.05  28.438 50.311 1 29.968  ? 264  ALA A C   1 
ATOM   2019 O  O   . ALA A 1 246 ? -29.864 28.81  49.469 1 27.895  ? 264  ALA A O   1 
ATOM   2020 C  CB  . ALA A 1 246 ? -30.393 29.697 52.028 1 30.659  ? 264  ALA A CB  1 
ATOM   2021 N  N   . GLN A 1 247 ? -27.886 27.86  49.986 1 30.313  ? 265  GLN A N   1 
ATOM   2022 C  CA  . GLN A 1 247 ? -27.477 27.715 48.585 1 31.379  ? 265  GLN A CA  1 
ATOM   2023 C  C   . GLN A 1 247 ? -28.185 26.548 47.882 1 29.283  ? 265  GLN A C   1 
ATOM   2024 O  O   . GLN A 1 247 ? -28.271 26.52  46.66  1 28.85   ? 265  GLN A O   1 
ATOM   2025 C  CB  . GLN A 1 247 ? -25.965 27.519 48.489 1 29.513  ? 265  GLN A CB  1 
ATOM   2026 C  CG  . GLN A 1 247 ? -25.465 26.195 49.065 1 31.667  ? 265  GLN A CG  1 
ATOM   2027 C  CD  . GLN A 1 247 ? -24.001 26.237 49.449 1 34.406  ? 265  GLN A CD  1 
ATOM   2028 O  OE1 . GLN A 1 247 ? -23.33  27.26  49.307 1 37.714  ? 265  GLN A OE1 1 
ATOM   2029 N  NE2 . GLN A 1 247 ? -23.498 25.139 49.983 1 35.43   ? 265  GLN A NE2 1 
ATOM   2030 N  N   . GLN A 1 248 ? -28.593 25.542 48.655 1 29.411  ? 266  GLN A N   1 
ATOM   2031 C  CA  . GLN A 1 248 ? -29.384 24.427 48.178 1 32.493  ? 266  GLN A CA  1 
ATOM   2032 C  C   . GLN A 1 248 ? -30.326 24.018 49.304 1 30.806  ? 266  GLN A C   1 
ATOM   2033 O  O   . GLN A 1 248 ? -29.94  24.136 50.46  1 28.602  ? 266  GLN A O   1 
ATOM   2034 C  CB  . GLN A 1 248 ? -28.482 23.227 47.939 1 35.677  ? 266  GLN A CB  1 
ATOM   2035 C  CG  . GLN A 1 248 ? -27.439 23.448 46.861 1 40.809  ? 266  GLN A CG  1 
ATOM   2036 C  CD  . GLN A 1 248 ? -26.629 22.192 46.638 1 46.214  ? 266  GLN A CD  1 
ATOM   2037 O  OE1 . GLN A 1 248 ? -26.179 21.534 47.593 1 47.957  ? 266  GLN A OE1 1 
ATOM   2038 N  NE2 . GLN A 1 248 ? -26.521 21.811 45.373 1 42.813  ? 266  GLN A NE2 1 
ATOM   2039 N  N   . TRP A 1 249 ? -31.523 23.517 48.974 1 29.316  ? 267  TRP A N   1 
ATOM   2040 C  CA  . TRP A 1 249 ? -32.556 23.318 49.984 1 29.807  ? 267  TRP A CA  1 
ATOM   2041 C  C   . TRP A 1 249 ? -32.939 21.842 50.103 1 31.727  ? 267  TRP A C   1 
ATOM   2042 O  O   . TRP A 1 249 ? -33.89  21.515 50.806 1 30.164  ? 267  TRP A O   1 
ATOM   2043 C  CB  . TRP A 1 249 ? -33.802 24.164 49.674 1 29.374  ? 267  TRP A CB  1 
ATOM   2044 C  CG  . TRP A 1 249 ? -33.556 25.624 49.387 1 27.381  ? 267  TRP A CG  1 
ATOM   2045 C  CD1 . TRP A 1 249 ? -32.454 26.37  49.674 1 28.212  ? 267  TRP A CD1 1 
ATOM   2046 C  CD2 . TRP A 1 249 ? -34.49  26.535 48.782 1 28.498  ? 267  TRP A CD2 1 
ATOM   2047 N  NE1 . TRP A 1 249 ? -32.604 27.652 49.231 1 28.909  ? 267  TRP A NE1 1 
ATOM   2048 C  CE2 . TRP A 1 249 ? -33.847 27.789 48.694 1 28.789  ? 267  TRP A CE2 1 
ATOM   2049 C  CE3 . TRP A 1 249 ? -35.798 26.411 48.303 1 29.321  ? 267  TRP A CE3 1 
ATOM   2050 C  CZ2 . TRP A 1 249 ? -34.465 28.908 48.154 1 29.19   ? 267  TRP A CZ2 1 
ATOM   2051 C  CZ3 . TRP A 1 249 ? -36.419 27.529 47.793 1 30.124  ? 267  TRP A CZ3 1 
ATOM   2052 C  CH2 . TRP A 1 249 ? -35.764 28.759 47.724 1 28.626  ? 267  TRP A CH2 1 
ATOM   2053 N  N   . SER A 1 250 ? -32.172 20.951 49.46  1 32.566  ? 268  SER A N   1 
ATOM   2054 C  CA  . SER A 1 250 ? -32.554 19.549 49.358 1 32.344  ? 268  SER A CA  1 
ATOM   2055 C  C   . SER A 1 250 ? -32.662 18.886 50.72  1 29.952  ? 268  SER A C   1 
ATOM   2056 O  O   . SER A 1 250 ? -33.407 17.944 50.844 1 33.277  ? 268  SER A O   1 
ATOM   2057 C  CB  . SER A 1 250 ? -31.632 18.763 48.47  1 35.107  ? 268  SER A CB  1 
ATOM   2058 O  OG  . SER A 1 250 ? -30.302 18.761 48.955 1 36.311  ? 268  SER A OG  1 
ATOM   2059 N  N   . GLU A 1 251 ? -31.987 19.404 51.746 1 31.807  ? 269  GLU A N   1 
ATOM   2060 C  CA  . GLU A 1 251 ? -32.08  18.836 53.085 1 32.28   ? 269  GLU A CA  1 
ATOM   2061 C  C   . GLU A 1 251 ? -33.45  19.051 53.733 1 32.405  ? 269  GLU A C   1 
ATOM   2062 O  O   . GLU A 1 251 ? -33.709 18.448 54.759 1 31.428  ? 269  GLU A O   1 
ATOM   2063 C  CB  . GLU A 1 251 ? -31.034 19.45  54.016 1 34.439  ? 269  GLU A CB  1 
ATOM   2064 C  CG  . GLU A 1 251 ? -29.586 19.107 53.649 1 43.341  ? 269  GLU A CG  1 
ATOM   2065 C  CD  . GLU A 1 251 ? -29.232 17.627 53.754 1 49.986  ? 269  GLU A CD  1 
ATOM   2066 O  OE1 . GLU A 1 251 ? -29.669 16.991 54.753 1 62.665  ? 269  GLU A OE1 1 
ATOM   2067 O  OE2 . GLU A 1 251 ? -28.545 17.111 52.833 1 58.489  ? 269  GLU A OE2 1 
ATOM   2068 N  N   . ILE A 1 252 ? -34.304 19.959 53.227 1 34.399  ? 270  ILE A N   1 
ATOM   2069 C  CA  . ILE A 1 252 ? -35.641 20.068 53.792 1 31.975  ? 270  ILE A CA  1 
ATOM   2070 C  C   . ILE A 1 252 ? -36.632 19.4   52.857 1 31.695  ? 270  ILE A C   1 
ATOM   2071 O  O   . ILE A 1 252 ? -37.808 19.706 52.937 1 32.612  ? 270  ILE A O   1 
ATOM   2072 C  CB  . ILE A 1 252 ? -36.07  21.513 54.087 1 32.564  ? 270  ILE A CB  1 
ATOM   2073 C  CG1 . ILE A 1 252 ? -36.122 22.358 52.831 1 33.18   ? 270  ILE A CG1 1 
ATOM   2074 C  CG2 . ILE A 1 252 ? -35.18  22.151 55.152 1 36.721  ? 270  ILE A CG2 1 
ATOM   2075 C  CD1 . ILE A 1 252 ? -37.014 23.569 52.977 1 37.523  ? 270  ILE A CD1 1 
ATOM   2076 N  N   . ALA A 1 253 ? -36.167 18.532 51.954 1 30.373  ? 271  ALA A N   1 
ATOM   2077 C  CA  . ALA A 1 253 ? -37.077 17.902 51.008 1 34.698  ? 271  ALA A CA  1 
ATOM   2078 C  C   . ALA A 1 253 ? -38.178 17.116 51.726 1 36.015  ? 271  ALA A C   1 
ATOM   2079 O  O   . ALA A 1 253 ? -39.277 16.934 51.214 1 35.102  ? 271  ALA A O   1 
ATOM   2080 C  CB  . ALA A 1 253 ? -36.303 17.01  50.06  1 35.549  ? 271  ALA A CB  1 
ATOM   2081 N  N   . ASP A 1 254 ? -37.896 16.644 52.934 1 39.013  ? 272  ASP A N   1 
ATOM   2082 C  CA  . ASP A 1 254 ? -38.849 15.784 53.606 1 46.608  ? 272  ASP A CA  1 
ATOM   2083 C  C   . ASP A 1 254 ? -40.044 16.604 54.082 1 47.943  ? 272  ASP A C   1 
ATOM   2084 O  O   . ASP A 1 254 ? -41.055 16.013 54.433 1 50.839  ? 272  ASP A O   1 
ATOM   2085 C  CB  . ASP A 1 254 ? -38.223 15.018 54.763 1 48.677  ? 272  ASP A CB  1 
ATOM   2086 C  CG  . ASP A 1 254 ? -37.743 15.902 55.904 1 55.652  ? 272  ASP A CG  1 
ATOM   2087 O  OD1 . ASP A 1 254 ? -36.901 16.774 55.629 1 63.03   ? 272  ASP A OD1 1 
ATOM   2088 O  OD2 . ASP A 1 254 ? -38.232 15.743 57.045 1 66.173  ? 272  ASP A OD2 1 
ATOM   2089 N  N   . ILE A 1 255 ? -39.937 17.94  54.134 1 46.859  ? 273  ILE A N   1 
ATOM   2090 C  CA  . ILE A 1 255 ? -41.072 18.719 54.593 1 45.068  ? 273  ILE A CA  1 
ATOM   2091 C  C   . ILE A 1 255 ? -41.72  19.512 53.466 1 42.894  ? 273  ILE A C   1 
ATOM   2092 O  O   . ILE A 1 255 ? -42.815 20.004 53.664 1 44.263  ? 273  ILE A O   1 
ATOM   2093 C  CB  . ILE A 1 255 ? -40.734 19.591 55.809 1 50.166  ? 273  ILE A CB  1 
ATOM   2094 C  CG1 . ILE A 1 255 ? -39.575 20.489 55.598 1 47.728  ? 273  ILE A CG1 1 
ATOM   2095 C  CG2 . ILE A 1 255 ? -40.522 18.723 57.053 1 52.842  ? 273  ILE A CG2 1 
ATOM   2096 C  CD1 . ILE A 1 255 ? -39.156 21.184 56.884 1 48.854  ? 273  ILE A CD1 1 
ATOM   2097 N  N   . VAL A 1 256 ? -41.133 19.543 52.267 1 39.058  ? 274  VAL A N   1 
ATOM   2098 C  CA  . VAL A 1 256 ? -41.659 20.377 51.198 1 34.797  ? 274  VAL A CA  1 
ATOM   2099 C  C   . VAL A 1 256 ? -41.934 19.551 49.948 1 34.8    ? 274  VAL A C   1 
ATOM   2100 O  O   . VAL A 1 256 ? -42.228 20.127 48.895 1 39.498  ? 274  VAL A O   1 
ATOM   2101 C  CB  . VAL A 1 256 ? -40.721 21.541 50.843 1 32.976  ? 274  VAL A CB  1 
ATOM   2102 C  CG1 . VAL A 1 256 ? -40.467 22.451 52.024 1 37.367  ? 274  VAL A CG1 1 
ATOM   2103 C  CG2 . VAL A 1 256 ? -39.4   21.027 50.306 1 40.648  ? 274  VAL A CG2 1 
ATOM   2104 N  N   . SER A 1 257 ? -41.855 18.22  50.036 1 37.505  ? 275  SER A N   1 
ATOM   2105 C  CA  . SER A 1 257 ? -41.96  17.413 48.825 1 41.372  ? 275  SER A CA  1 
ATOM   2106 C  C   . SER A 1 257 ? -43.41  17.345 48.353 1 37.741  ? 275  SER A C   1 
ATOM   2107 O  O   . SER A 1 257 ? -44.354 17.264 49.139 1 37.135  ? 275  SER A O   1 
ATOM   2108 C  CB  . SER A 1 257 ? -41.362 16.048 48.947 1 43.226  ? 275  SER A CB  1 
ATOM   2109 O  OG  . SER A 1 257 ? -42.284 15.201 49.598 1 49.597  ? 275  SER A OG  1 
ATOM   2110 N  N   . PRO A 1 258 ? -43.607 17.445 47.029 1 34.721  ? 276  PRO A N   1 
ATOM   2111 C  CA  . PRO A 1 258 ? -44.927 17.478 46.418 1 35.718  ? 276  PRO A CA  1 
ATOM   2112 C  C   . PRO A 1 258 ? -45.881 16.372 46.845 1 36.61   ? 276  PRO A C   1 
ATOM   2113 O  O   . PRO A 1 258 ? -47.045 16.622 47.086 1 37.407  ? 276  PRO A O   1 
ATOM   2114 C  CB  . PRO A 1 258 ? -44.588 17.315 44.946 1 36.694  ? 276  PRO A CB  1 
ATOM   2115 C  CG  . PRO A 1 258 ? -43.304 18.126 44.872 1 36.163  ? 276  PRO A CG  1 
ATOM   2116 C  CD  . PRO A 1 258 ? -42.54  17.645 46.046 1 34.352  ? 276  PRO A CD  1 
ATOM   2117 N  N   . PHE A 1 259 ? -45.378 15.144 46.907 1 37.104  ? 277  PHE A N   1 
ATOM   2118 C  CA  . PHE A 1 259 ? -46.185 13.987 47.201 1 34.756  ? 277  PHE A CA  1 
ATOM   2119 C  C   . PHE A 1 259 ? -45.579 13.248 48.374 1 38.138  ? 277  PHE A C   1 
ATOM   2120 O  O   . PHE A 1 259 ? -44.886 12.259 48.179 1 40.493  ? 277  PHE A O   1 
ATOM   2121 C  CB  . PHE A 1 259 ? -46.207 13.14  45.937 1 32.941  ? 277  PHE A CB  1 
ATOM   2122 C  CG  . PHE A 1 259 ? -47.006 13.807 44.837 1 31.436  ? 277  PHE A CG  1 
ATOM   2123 C  CD1 . PHE A 1 259 ? -48.395 13.865 44.916 1 33.16   ? 277  PHE A CD1 1 
ATOM   2124 C  CD2 . PHE A 1 259 ? -46.377 14.339 43.728 1 32.191  ? 277  PHE A CD2 1 
ATOM   2125 C  CE1 . PHE A 1 259 ? -49.139 14.451 43.898 1 33.617  ? 277  PHE A CE1 1 
ATOM   2126 C  CE2 . PHE A 1 259 ? -47.117 14.923 42.712 1 36.674  ? 277  PHE A CE2 1 
ATOM   2127 C  CZ  . PHE A 1 259 ? -48.501 14.981 42.796 1 37.934  ? 277  PHE A CZ  1 
ATOM   2128 N  N   . PRO A 1 260 ? -45.86  13.675 49.618 1 41.14   ? 278  PRO A N   1 
ATOM   2129 C  CA  . PRO A 1 260 ? -45.252 13.053 50.79  1 43.779  ? 278  PRO A CA  1 
ATOM   2130 C  C   . PRO A 1 260 ? -45.674 11.609 51.071 1 47.831  ? 278  PRO A C   1 
ATOM   2131 O  O   . PRO A 1 260 ? -45.058 10.955 51.903 1 46.01   ? 278  PRO A O   1 
ATOM   2132 C  CB  . PRO A 1 260 ? -45.637 13.964 51.952 1 42.193  ? 278  PRO A CB  1 
ATOM   2133 C  CG  . PRO A 1 260 ? -46.783 14.785 51.423 1 43.17   ? 278  PRO A CG  1 
ATOM   2134 C  CD  . PRO A 1 260 ? -46.744 14.804 49.926 1 40.927  ? 278  PRO A CD  1 
ATOM   2135 N  N   . GLU A 1 261 ? -46.723 11.112 50.405 1 58.585  ? 279  GLU A N   1 
ATOM   2136 C  CA  . GLU A 1 261 ? -47.129 9.722  50.564 1 62.813  ? 279  GLU A CA  1 
ATOM   2137 C  C   . GLU A 1 261 ? -46.398 8.84   49.542 1 57.526  ? 279  GLU A C   1 
ATOM   2138 O  O   . GLU A 1 261 ? -46.508 7.618  49.588 1 55.401  ? 279  GLU A O   1 
ATOM   2139 C  CB  . GLU A 1 261 ? -48.656 9.612  50.479 1 74.49   ? 279  GLU A CB  1 
ATOM   2140 C  CG  . GLU A 1 261 ? -49.429 10.408 51.54  1 98.293  ? 279  GLU A CG  1 
ATOM   2141 C  CD  . GLU A 1 261 ? -49.026 10.37  53.029 1 115.106 ? 279  GLU A CD  1 
ATOM   2142 O  OE1 . GLU A 1 261 ? -48.81  9.273  53.605 1 104.876 ? 279  GLU A OE1 1 
ATOM   2143 O  OE2 . GLU A 1 261 ? -48.966 11.465 53.659 1 107.108 ? 279  GLU A OE2 1 
ATOM   2144 N  N   . LYS A 1 262 ? -45.653 9.462  48.619 1 48.651  ? 280  LYS A N   1 
ATOM   2145 C  CA  . LYS A 1 262 ? -44.891 8.752  47.604 1 50.777  ? 280  LYS A CA  1 
ATOM   2146 C  C   . LYS A 1 262 ? -43.402 8.82   47.967 1 53.645  ? 280  LYS A C   1 
ATOM   2147 O  O   . LYS A 1 262 ? -43.002 9.611  48.824 1 46.959  ? 280  LYS A O   1 
ATOM   2148 C  CB  . LYS A 1 262 ? -45.271 9.288  46.213 1 50.383  ? 280  LYS A CB  1 
ATOM   2149 C  CG  . LYS A 1 262 ? -46.667 8.877  45.707 1 52.818  ? 280  LYS A CG  1 
ATOM   2150 C  CD  . LYS A 1 262 ? -46.922 7.369  45.657 1 58.762  ? 280  LYS A CD  1 
ATOM   2151 C  CE  . LYS A 1 262 ? -48.29  6.991  45.165 1 60.789  ? 280  LYS A CE  1 
ATOM   2152 N  NZ  . LYS A 1 262 ? -48.561 7.487  43.81  1 61.114  ? 280  LYS A NZ  1 
ATOM   2153 N  N   . PRO A 1 263 ? -42.54  7.948  47.382 1 55.518  ? 281  PRO A N   1 
ATOM   2154 C  CA  . PRO A 1 263 ? -41.15  7.855  47.822 1 57.137  ? 281  PRO A CA  1 
ATOM   2155 C  C   . PRO A 1 263 ? -40.303 9.086  47.475 1 48.41   ? 281  PRO A C   1 
ATOM   2156 O  O   . PRO A 1 263 ? -40.435 9.722  46.423 1 38.845  ? 281  PRO A O   1 
ATOM   2157 C  CB  . PRO A 1 263 ? -40.647 6.567  47.162 1 52.311  ? 281  PRO A CB  1 
ATOM   2158 C  CG  . PRO A 1 263 ? -41.47  6.515  45.884 1 54.982  ? 281  PRO A CG  1 
ATOM   2159 C  CD  . PRO A 1 263 ? -42.839 7.028  46.268 1 53.897  ? 281  PRO A CD  1 
ATOM   2160 N  N   . LEU A 1 264 ? -39.429 9.418  48.417 1 46.242  ? 282  LEU A N   1 
ATOM   2161 C  CA  . LEU A 1 264 ? -38.44  10.458 48.222 1 51.883  ? 282  LEU A CA  1 
ATOM   2162 C  C   . LEU A 1 264 ? -37.055 9.852  48.437 1 46.825  ? 282  LEU A C   1 
ATOM   2163 O  O   . LEU A 1 264 ? -36.78  9.319  49.522 1 39.546  ? 282  LEU A O   1 
ATOM   2164 C  CB  . LEU A 1 264 ? -38.739 11.564 49.224 1 52.173  ? 282  LEU A CB  1 
ATOM   2165 C  CG  . LEU A 1 264 ? -37.843 12.793 49.133 1 58.083  ? 282  LEU A CG  1 
ATOM   2166 C  CD1 . LEU A 1 264 ? -38.115 13.579 47.846 1 55.109  ? 282  LEU A CD1 1 
ATOM   2167 C  CD2 . LEU A 1 264 ? -38.093 13.586 50.404 1 61.544  ? 282  LEU A CD2 1 
ATOM   2168 N  N   . VAL A 1 265 ? -36.195 9.965  47.409 1 42.605  ? 283  VAL A N   1 
ATOM   2169 C  CA  . VAL A 1 265 ? -34.923 9.267  47.433 1 42.314  ? 283  VAL A CA  1 
ATOM   2170 C  C   . VAL A 1 265 ? -34.037 9.913  48.502 1 40.521  ? 283  VAL A C   1 
ATOM   2171 O  O   . VAL A 1 265 ? -33.739 11.104 48.448 1 40.562  ? 283  VAL A O   1 
ATOM   2172 C  CB  . VAL A 1 265 ? -34.264 9.226  46.044 1 42.789  ? 283  VAL A CB  1 
ATOM   2173 C  CG1 . VAL A 1 265 ? -32.888 8.568  46.102 1 40.004  ? 283  VAL A CG1 1 
ATOM   2174 C  CG2 . VAL A 1 265 ? -35.148 8.54   44.999 1 41.547  ? 283  VAL A CG2 1 
ATOM   2175 N  N   . ASP A 1 266 ? -33.699 9.11   49.516 1 40.216  ? 284  ASP A N   1 
ATOM   2176 C  CA  . ASP A 1 266 ? -32.741 9.472  50.543 1 42.542  ? 284  ASP A CA  1 
ATOM   2177 C  C   . ASP A 1 266 ? -31.971 8.215  50.982 1 39.431  ? 284  ASP A C   1 
ATOM   2178 O  O   . ASP A 1 266 ? -32.363 7.539  51.925 1 29.919  ? 284  ASP A O   1 
ATOM   2179 C  CB  . ASP A 1 266 ? -33.429 10.176 51.7   1 47.245  ? 284  ASP A CB  1 
ATOM   2180 C  CG  . ASP A 1 266 ? -32.462 10.726 52.744 1 59.174  ? 284  ASP A CG  1 
ATOM   2181 O  OD1 . ASP A 1 266 ? -31.263 10.36  52.659 1 59.76   ? 284  ASP A OD1 1 
ATOM   2182 O  OD2 . ASP A 1 266 ? -32.898 11.536 53.611 1 64.499  ? 284  ASP A OD2 1 
ATOM   2183 N  N   . VAL A 1 267 ? -30.813 7.95   50.359 1 37.925  ? 285  VAL A N   1 
ATOM   2184 C  CA  . VAL A 1 267 ? -30.13  6.673  50.515 1 36.32   ? 285  VAL A CA  1 
ATOM   2185 C  C   . VAL A 1 267 ? -29.115 6.669  51.657 1 34.716  ? 285  VAL A C   1 
ATOM   2186 O  O   . VAL A 1 267 ? -28.437 5.667  51.888 1 35.939  ? 285  VAL A O   1 
ATOM   2187 C  CB  . VAL A 1 267 ? -29.484 6.314  49.173 1 35.665  ? 285  VAL A CB  1 
ATOM   2188 C  CG1 . VAL A 1 267 ? -30.546 6.259  48.082 1 36.86   ? 285  VAL A CG1 1 
ATOM   2189 C  CG2 . VAL A 1 267 ? -28.364 7.283  48.798 1 38.356  ? 285  VAL A CG2 1 
ATOM   2190 N  N   . SER A 1 268 ? -29.043 7.748  52.429 1 35.093  ? 286  SER A N   1 
ATOM   2191 C  CA  . SER A 1 268 ? -28.059 7.812  53.489 1 36.263  ? 286  SER A CA  1 
ATOM   2192 C  C   . SER A 1 268 ? -28.187 6.593  54.385 1 39.418  ? 286  SER A C   1 
ATOM   2193 O  O   . SER A 1 268 ? -27.185 5.97   54.728 1 43.26   ? 286  SER A O   1 
ATOM   2194 C  CB  . SER A 1 268 ? -28.155 9.085  54.287 1 37.437  ? 286  SER A CB  1 
ATOM   2195 O  OG  . SER A 1 268 ? -28.088 10.214 53.429 1 38.154  ? 286  SER A OG  1 
ATOM   2196 N  N   . ALA A 1 269 ? -29.426 6.27   54.771 1 44.682  ? 287  ALA A N   1 
ATOM   2197 C  CA  . ALA A 1 269 ? -29.656 5.277  55.816 1 46.036  ? 287  ALA A CA  1 
ATOM   2198 C  C   . ALA A 1 269 ? -29.221 3.883  55.35  1 39.638  ? 287  ALA A C   1 
ATOM   2199 O  O   . ALA A 1 269 ? -28.629 3.149  56.137 1 39.41   ? 287  ALA A O   1 
ATOM   2200 C  CB  . ALA A 1 269 ? -31.101 5.32   56.279 1 43.283  ? 287  ALA A CB  1 
ATOM   2201 N  N   . GLU A 1 270 ? -29.493 3.555  54.074 1 39.221  ? 288  GLU A N   1 
ATOM   2202 C  CA  . GLU A 1 270 ? -29.028 2.344  53.396 1 43.708  ? 288  GLU A CA  1 
ATOM   2203 C  C   . GLU A 1 270 ? -27.498 2.278  53.208 1 44.633  ? 288  GLU A C   1 
ATOM   2204 O  O   . GLU A 1 270 ? -26.9   1.216  53.372 1 36.306  ? 288  GLU A O   1 
ATOM   2205 C  CB  . GLU A 1 270 ? -29.683 2.238  52.015 1 49.567  ? 288  GLU A CB  1 
ATOM   2206 C  CG  . GLU A 1 270 ? -31.128 1.749  52.056 1 65.289  ? 288  GLU A CG  1 
ATOM   2207 C  CD  . GLU A 1 270 ? -31.262 0.343  52.631 1 71.219  ? 288  GLU A CD  1 
ATOM   2208 O  OE1 . GLU A 1 270 ? -30.407 -0.528 52.308 1 71.292  ? 288  GLU A OE1 1 
ATOM   2209 O  OE2 . GLU A 1 270 ? -32.223 0.138  53.411 1 69.859  ? 288  GLU A OE2 1 
ATOM   2210 N  N   . MET A 1 271 ? -26.854 3.387  52.811 1 40.525  ? 289  MET A N   1 
ATOM   2211 C  CA  . MET A 1 271 ? -25.403 3.44   52.798 1 38.074  ? 289  MET A CA  1 
ATOM   2212 C  C   . MET A 1 271 ? -24.865 2.974  54.16  1 39.451  ? 289  MET A C   1 
ATOM   2213 O  O   . MET A 1 271 ? -24.044 2.051  54.212 1 38.809  ? 289  MET A O   1 
ATOM   2214 C  CB  . MET A 1 271 ? -24.91  4.849  52.456 1 35.158  ? 289  MET A CB  1 
ATOM   2215 C  CG  . MET A 1 271 ? -25.232 5.314  51.042 1 35.77   ? 289  MET A CG  1 
ATOM   2216 S  SD  . MET A 1 271 ? -24.825 7.059  50.77  1 37.17   ? 289  MET A SD  1 
ATOM   2217 C  CE  . MET A 1 271 ? -23.024 7.04   50.743 1 37.114  ? 289  MET A CE  1 
ATOM   2218 N  N   . GLU A 1 272 ? -25.358 3.57   55.256 1 37.852  ? 290  GLU A N   1 
ATOM   2219 C  CA  . GLU A 1 272 ? -24.888 3.252  56.602 1 44.97   ? 290  GLU A CA  1 
ATOM   2220 C  C   . GLU A 1 272 ? -25.137 1.782  56.93  1 49.676  ? 290  GLU A C   1 
ATOM   2221 O  O   . GLU A 1 272 ? -24.286 1.138  57.533 1 54.556  ? 290  GLU A O   1 
ATOM   2222 C  CB  . GLU A 1 272 ? -25.541 4.071  57.722 1 54.538  ? 290  GLU A CB  1 
ATOM   2223 C  CG  . GLU A 1 272 ? -24.769 5.323  58.133 1 73.123  ? 290  GLU A CG  1 
ATOM   2224 C  CD  . GLU A 1 272 ? -25.653 6.439  58.677 1 88.181  ? 290  GLU A CD  1 
ATOM   2225 O  OE1 . GLU A 1 272 ? -26.223 7.205  57.859 1 98.182  ? 290  GLU A OE1 1 
ATOM   2226 O  OE2 . GLU A 1 272 ? -25.803 6.524  59.916 1 92.746  ? 290  GLU A OE2 1 
ATOM   2227 N  N   . LYS A 1 273 ? -26.312 1.271  56.555 1 55.565  ? 291  LYS A N   1 
ATOM   2228 C  CA  . LYS A 1 273 ? -26.732 -0.07  56.922 1 60.759  ? 291  LYS A CA  1 
ATOM   2229 C  C   . LYS A 1 273 ? -25.926 -1.097 56.119 1 59.609  ? 291  LYS A C   1 
ATOM   2230 O  O   . LYS A 1 273 ? -25.67  -2.178 56.627 1 58.806  ? 291  LYS A O   1 
ATOM   2231 C  CB  . LYS A 1 273 ? -28.258 -0.139 56.778 1 67.751  ? 291  LYS A CB  1 
ATOM   2232 C  CG  . LYS A 1 273 ? -28.881 -1.518 56.63  1 80.204  ? 291  LYS A CG  1 
ATOM   2233 C  CD  . LYS A 1 273 ? -29.709 -1.607 55.35  1 96.264  ? 291  LYS A CD  1 
ATOM   2234 C  CE  . LYS A 1 273 ? -30.158 -2.981 54.946 1 98.61   ? 291  LYS A CE  1 
ATOM   2235 N  NZ  . LYS A 1 273 ? -31.285 -3.415 55.774 1 93.864  ? 291  LYS A NZ  1 
ATOM   2236 N  N   . GLN A 1 274 ? -25.51  -0.765 54.887 1 51.648  ? 292  GLN A N   1 
ATOM   2237 C  CA  . GLN A 1 274 ? -24.667 -1.64  54.086 1 43.634  ? 292  GLN A CA  1 
ATOM   2238 C  C   . GLN A 1 274 ? -23.168 -1.478 54.397 1 42.021  ? 292  GLN A C   1 
ATOM   2239 O  O   . GLN A 1 274 ? -22.343 -1.981 53.637 1 41.768  ? 292  GLN A O   1 
ATOM   2240 C  CB  . GLN A 1 274 ? -24.846 -1.407 52.584 1 47.843  ? 292  GLN A CB  1 
ATOM   2241 C  CG  . GLN A 1 274 ? -25.942 -2.257 51.957 1 54.725  ? 292  GLN A CG  1 
ATOM   2242 C  CD  . GLN A 1 274 ? -26.358 -1.807 50.573 1 58.735  ? 292  GLN A CD  1 
ATOM   2243 O  OE1 . GLN A 1 274 ? -25.544 -1.65  49.639 1 50.426  ? 292  GLN A OE1 1 
ATOM   2244 N  NE2 . GLN A 1 274 ? -27.664 -1.584 50.457 1 59.826  ? 292  GLN A NE2 1 
ATOM   2245 N  N   . GLY A 1 275 ? -22.807 -0.782 55.489 1 39.268  ? 293  GLY A N   1 
ATOM   2246 C  CA  . GLY A 1 275 ? -21.422 -0.626 55.935 1 40.334  ? 293  GLY A CA  1 
ATOM   2247 C  C   . GLY A 1 275 ? -20.515 0.238  55.037 1 42.185  ? 293  GLY A C   1 
ATOM   2248 O  O   . GLY A 1 275 ? -19.297 0.115  55.112 1 41.461  ? 293  GLY A O   1 
ATOM   2249 N  N   . TYR A 1 276 ? -21.081 1.137  54.215 1 41.994  ? 294  TYR A N   1 
ATOM   2250 C  CA  . TYR A 1 276 ? -20.297 2.045  53.384 1 37.514  ? 294  TYR A CA  1 
ATOM   2251 C  C   . TYR A 1 276 ? -19.285 2.794  54.247 1 35.465  ? 294  TYR A C   1 
ATOM   2252 O  O   . TYR A 1 276 ? -19.57  3.156  55.383 1 35.679  ? 294  TYR A O   1 
ATOM   2253 C  CB  . TYR A 1 276 ? -21.136 3.091  52.645 1 35.885  ? 294  TYR A CB  1 
ATOM   2254 C  CG  . TYR A 1 276 ? -21.732 2.629  51.327 1 38.364  ? 294  TYR A CG  1 
ATOM   2255 C  CD1 . TYR A 1 276 ? -22.332 1.384  51.19  1 44.343  ? 294  TYR A CD1 1 
ATOM   2256 C  CD2 . TYR A 1 276 ? -21.637 3.418  50.196 1 42.826  ? 294  TYR A CD2 1 
ATOM   2257 C  CE1 . TYR A 1 276 ? -22.855 0.951  49.982 1 40.42   ? 294  TYR A CE1 1 
ATOM   2258 C  CE2 . TYR A 1 276 ? -22.164 3.005  48.984 1 45.961  ? 294  TYR A CE2 1 
ATOM   2259 C  CZ  . TYR A 1 276 ? -22.764 1.763  48.869 1 42.024  ? 294  TYR A CZ  1 
ATOM   2260 O  OH  . TYR A 1 276 ? -23.295 1.376  47.666 1 42.282  ? 294  TYR A OH  1 
ATOM   2261 N  N   . THR A 1 277 ? -18.082 2.974  53.69  1 38.816  ? 295  THR A N   1 
ATOM   2262 C  CA  . THR A 1 277 ? -17.061 3.852  54.243 1 37.704  ? 295  THR A CA  1 
ATOM   2263 C  C   . THR A 1 277 ? -16.729 4.918  53.193 1 35.183  ? 295  THR A C   1 
ATOM   2264 O  O   . THR A 1 277 ? -17.078 4.802  52.003 1 34.711  ? 295  THR A O   1 
ATOM   2265 C  CB  . THR A 1 277 ? -15.799 3.061  54.626 1 36.333  ? 295  THR A CB  1 
ATOM   2266 O  OG1 . THR A 1 277 ? -15.355 2.412  53.438 1 34.762  ? 295  THR A OG1 1 
ATOM   2267 C  CG2 . THR A 1 277 ? -16.031 1.991  55.676 1 38.997  ? 295  THR A CG2 1 
ATOM   2268 N  N   . PRO A 1 278 ? -15.981 5.96   53.602 1 30.955  ? 296  PRO A N   1 
ATOM   2269 C  CA  . PRO A 1 278 ? -15.37  6.87   52.648 1 33.51   ? 296  PRO A CA  1 
ATOM   2270 C  C   . PRO A 1 278 ? -14.611 6.147  51.543 1 35.548  ? 296  PRO A C   1 
ATOM   2271 O  O   . PRO A 1 278 ? -14.803 6.436  50.347 1 32.271  ? 296  PRO A O   1 
ATOM   2272 C  CB  . PRO A 1 278 ? -14.492 7.751  53.542 1 38.235  ? 296  PRO A CB  1 
ATOM   2273 C  CG  . PRO A 1 278 ? -15.207 7.732  54.887 1 36.049  ? 296  PRO A CG  1 
ATOM   2274 C  CD  . PRO A 1 278 ? -15.736 6.335  55.009 1 33.345  ? 296  PRO A CD  1 
ATOM   2275 N  N   . LEU A 1 279 ? -13.786 5.168  51.953 1 34.216  ? 297  LEU A N   1 
ATOM   2276 C  CA  . LEU A 1 279 ? -12.994 4.421  50.994 1 37.014  ? 297  LEU A CA  1 
ATOM   2277 C  C   . LEU A 1 279 ? -13.877 3.788  49.919 1 36.094  ? 297  LEU A C   1 
ATOM   2278 O  O   . LEU A 1 279 ? -13.596 3.922  48.724 1 36.041  ? 297  LEU A O   1 
ATOM   2279 C  CB  . LEU A 1 279 ? -12.155 3.374  51.712 1 41.04   ? 297  LEU A CB  1 
ATOM   2280 C  CG  . LEU A 1 279 ? -11.221 2.573  50.799 1 44.933  ? 297  LEU A CG  1 
ATOM   2281 C  CD1 . LEU A 1 279 ? -10.188 3.524  50.184 1 42.269  ? 297  LEU A CD1 1 
ATOM   2282 C  CD2 . LEU A 1 279 ? -10.535 1.421  51.546 1 43.477  ? 297  LEU A CD2 1 
ATOM   2283 N  N   . LYS A 1 280 ? -14.949 3.101  50.344 1 38.549  ? 298  LYS A N   1 
ATOM   2284 C  CA  . LYS A 1 280 ? -15.884 2.514  49.391 1 40.054  ? 298  LYS A CA  1 
ATOM   2285 C  C   . LYS A 1 280 ? -16.464 3.587  48.45  1 34.792  ? 298  LYS A C   1 
ATOM   2286 O  O   . LYS A 1 280 ? -16.592 3.367  47.25  1 29.196  ? 298  LYS A O   1 
ATOM   2287 C  CB  . LYS A 1 280 ? -16.988 1.711  50.098 1 43.261  ? 298  LYS A CB  1 
ATOM   2288 C  CG  . LYS A 1 280 ? -17.868 0.863  49.168 1 50.509  ? 298  LYS A CG  1 
ATOM   2289 C  CD  . LYS A 1 280 ? -17.036 -0.305 48.631 1 75.894  ? 298  LYS A CD  1 
ATOM   2290 C  CE  . LYS A 1 280 ? -17.506 -1.023 47.399 1 85.131  ? 298  LYS A CE  1 
ATOM   2291 N  NZ  . LYS A 1 280 ? -18.864 -1.511 47.617 1 90.934  ? 298  LYS A NZ  1 
ATOM   2292 N  N   . MET A 1 281 ? -16.874 4.735  48.991 1 32.205  ? 299  MET A N   1 
ATOM   2293 C  CA  . MET A 1 281 ? -17.486 5.782  48.174 1 32.151  ? 299  MET A CA  1 
ATOM   2294 C  C   . MET A 1 281 ? -16.533 6.264  47.078 1 31.209  ? 299  MET A C   1 
ATOM   2295 O  O   . MET A 1 281 ? -16.945 6.432  45.922 1 35.747  ? 299  MET A O   1 
ATOM   2296 C  CB  . MET A 1 281 ? -17.896 6.963  49.058 1 32.43   ? 299  MET A CB  1 
ATOM   2297 C  CG  . MET A 1 281 ? -19.063 6.635  49.99  1 33.632  ? 299  MET A CG  1 
ATOM   2298 S  SD  . MET A 1 281 ? -19.225 7.701  51.433 1 34.957  ? 299  MET A SD  1 
ATOM   2299 C  CE  . MET A 1 281 ? -19.878 9.137  50.581 1 35.049  ? 299  MET A CE  1 
ATOM   2300 N  N   . PHE A 1 282 ? -15.247 6.441  47.415 1 29.224  ? 300  PHE A N   1 
ATOM   2301 C  CA  . PHE A 1 282 ? -14.267 6.848  46.416 1 32.601  ? 300  PHE A CA  1 
ATOM   2302 C  C   . PHE A 1 282 ? -14.038 5.732  45.398 1 33.479  ? 300  PHE A C   1 
ATOM   2303 O  O   . PHE A 1 282 ? -13.927 5.991  44.193 1 32.417  ? 300  PHE A O   1 
ATOM   2304 C  CB  . PHE A 1 282 ? -12.946 7.275  47.059 1 35.566  ? 300  PHE A CB  1 
ATOM   2305 C  CG  . PHE A 1 282 ? -13.021 8.707  47.543 1 35.563  ? 300  PHE A CG  1 
ATOM   2306 C  CD1 . PHE A 1 282 ? -13.495 8.998  48.812 1 34.086  ? 300  PHE A CD1 1 
ATOM   2307 C  CD2 . PHE A 1 282 ? -12.672 9.751  46.7   1 37.503  ? 300  PHE A CD2 1 
ATOM   2308 C  CE1 . PHE A 1 282 ? -13.588 10.308 49.245 1 36.15   ? 300  PHE A CE1 1 
ATOM   2309 C  CE2 . PHE A 1 282 ? -12.775 11.063 47.134 1 37.935  ? 300  PHE A CE2 1 
ATOM   2310 C  CZ  . PHE A 1 282 ? -13.217 11.337 48.409 1 36.658  ? 300  PHE A CZ  1 
ATOM   2311 N  N   . GLN A 1 283 ? -14.013 4.48   45.88  1 34.744  ? 301  GLN A N   1 
ATOM   2312 C  CA  . GLN A 1 283 ? -13.851 3.341  44.987 1 36.048  ? 301  GLN A CA  1 
ATOM   2313 C  C   . GLN A 1 283 ? -15.033 3.252  44.037 1 34.264  ? 301  GLN A C   1 
ATOM   2314 O  O   . GLN A 1 283 ? -14.85  2.925  42.873 1 37.809  ? 301  GLN A O   1 
ATOM   2315 C  CB  . GLN A 1 283 ? -13.666 2.021  45.734 1 41.408  ? 301  GLN A CB  1 
ATOM   2316 C  CG  . GLN A 1 283 ? -12.389 1.966  46.571 1 43.848  ? 301  GLN A CG  1 
ATOM   2317 C  CD  . GLN A 1 283 ? -12.36  0.824  47.562 1 43.904  ? 301  GLN A CD  1 
ATOM   2318 O  OE1 . GLN A 1 283 ? -13.378 0.202  47.865 1 44.32   ? 301  GLN A OE1 1 
ATOM   2319 N  NE2 . GLN A 1 283 ? -11.18  0.546  48.088 1 46.437  ? 301  GLN A NE2 1 
ATOM   2320 N  N   . MET A 1 284 ? -16.243 3.575  44.5   1 35.501  ? 302  MET A N   1 
ATOM   2321 C  CA  . MET A 1 284 ? -17.382 3.595  43.591 1 36.648  ? 302  MET A CA  1 
ATOM   2322 C  C   . MET A 1 284 ? -17.239 4.7    42.547 1 33.06   ? 302  MET A C   1 
ATOM   2323 O  O   . MET A 1 284 ? -17.577 4.511  41.368 1 29.329  ? 302  MET A O   1 
ATOM   2324 C  CB  . MET A 1 284 ? -18.693 3.753  44.355 1 44.155  ? 302  MET A CB  1 
ATOM   2325 C  CG  . MET A 1 284 ? -19.067 2.493  45.106 1 53.51   ? 302  MET A CG  1 
ATOM   2326 S  SD  . MET A 1 284 ? -20.344 2.808  46.34  1 69.495  ? 302  MET A SD  1 
ATOM   2327 C  CE  . MET A 1 284 ? -21.686 2.926  45.144 1 70.528  ? 302  MET A CE  1 
ATOM   2328 N  N   . GLY A 1 285 ? -16.769 5.872  42.98  1 31.956  ? 303  GLY A N   1 
ATOM   2329 C  CA  . GLY A 1 285 ? -16.593 6.951  42.03  1 32.989  ? 303  GLY A CA  1 
ATOM   2330 C  C   . GLY A 1 285 ? -15.586 6.523  40.965 1 32.787  ? 303  GLY A C   1 
ATOM   2331 O  O   . GLY A 1 285 ? -15.855 6.632  39.763 1 31.147  ? 303  GLY A O   1 
ATOM   2332 N  N   . ASP A 1 286 ? -14.463 5.978  41.44  1 29.723  ? 304  ASP A N   1 
ATOM   2333 C  CA  . ASP A 1 286 ? -13.449 5.425  40.545 1 38.048  ? 304  ASP A CA  1 
ATOM   2334 C  C   . ASP A 1 286 ? -14.069 4.452  39.548 1 37.435  ? 304  ASP A C   1 
ATOM   2335 O  O   . ASP A 1 286 ? -13.841 4.595  38.341 1 33.982  ? 304  ASP A O   1 
ATOM   2336 C  CB  . ASP A 1 286 ? -12.314 4.737  41.287 1 43.572  ? 304  ASP A CB  1 
ATOM   2337 C  CG  . ASP A 1 286 ? -11.101 4.353  40.446 1 50.877  ? 304  ASP A CG  1 
ATOM   2338 O  OD1 . ASP A 1 286 ? -11.014 4.807  39.282 1 51.363  ? 304  ASP A OD1 1 
ATOM   2339 O  OD2 . ASP A 1 286 ? -10.242 3.598  40.965 1 51.809  ? 304  ASP A OD2 1 
ATOM   2340 N  N   . ASP A 1 287 ? -14.873 3.491  40.055 1 36.762  ? 305  ASP A N   1 
ATOM   2341 C  CA  . ASP A 1 287 ? -15.543 2.538  39.183 1 35.327  ? 305  ASP A CA  1 
ATOM   2342 C  C   . ASP A 1 287 ? -16.346 3.266  38.122 1 33.736  ? 305  ASP A C   1 
ATOM   2343 O  O   . ASP A 1 287 ? -16.281 2.872  36.96  1 32.948  ? 305  ASP A O   1 
ATOM   2344 C  CB  . ASP A 1 287 ? -16.474 1.53   39.854 1 41.588  ? 305  ASP A CB  1 
ATOM   2345 C  CG  . ASP A 1 287 ? -17.226 0.633  38.858 1 48.424  ? 305  ASP A CG  1 
ATOM   2346 O  OD1 . ASP A 1 287 ? -16.58  0.086  37.898 1 49.594  ? 305  ASP A OD1 1 
ATOM   2347 O  OD2 . ASP A 1 287 ? -18.46  0.482  39.023 1 52.855  ? 305  ASP A OD2 1 
ATOM   2348 N  N   . PHE A 1 288 ? -17.119 4.292  38.527 1 32.746  ? 306  PHE A N   1 
ATOM   2349 C  CA  . PHE A 1 288 ? -17.947 5.014  37.573 1 32.087  ? 306  PHE A CA  1 
ATOM   2350 C  C   . PHE A 1 288 ? -17.105 5.502  36.397 1 31.015  ? 306  PHE A C   1 
ATOM   2351 O  O   . PHE A 1 288 ? -17.478 5.339  35.242 1 31.179  ? 306  PHE A O   1 
ATOM   2352 C  CB  . PHE A 1 288 ? -18.685 6.223  38.176 1 34.804  ? 306  PHE A CB  1 
ATOM   2353 C  CG  . PHE A 1 288 ? -19.986 6.554  37.454 1 29.477  ? 306  PHE A CG  1 
ATOM   2354 C  CD1 . PHE A 1 288 ? -19.979 6.998  36.131 1 30.079  ? 306  PHE A CD1 1 
ATOM   2355 C  CD2 . PHE A 1 288 ? -21.21  6.401  38.093 1 32.072  ? 306  PHE A CD2 1 
ATOM   2356 C  CE1 . PHE A 1 288 ? -21.168 7.281  35.469 1 30.82   ? 306  PHE A CE1 1 
ATOM   2357 C  CE2 . PHE A 1 288 ? -22.402 6.703  37.435 1 30.703  ? 306  PHE A CE2 1 
ATOM   2358 C  CZ  . PHE A 1 288 ? -22.379 7.121  36.122 1 31.631  ? 306  PHE A CZ  1 
ATOM   2359 N  N   . PHE A 1 289 ? -15.978 6.148  36.679 1 33.088  ? 307  PHE A N   1 
ATOM   2360 C  CA  . PHE A 1 289 ? -15.173 6.699  35.598 1 37.502  ? 307  PHE A CA  1 
ATOM   2361 C  C   . PHE A 1 289 ? -14.591 5.571  34.737 1 37.805  ? 307  PHE A C   1 
ATOM   2362 O  O   . PHE A 1 289 ? -14.635 5.652  33.508 1 36.73   ? 307  PHE A O   1 
ATOM   2363 C  CB  . PHE A 1 289 ? -14.066 7.611  36.145 1 36.821  ? 307  PHE A CB  1 
ATOM   2364 C  CG  . PHE A 1 289 ? -14.537 8.995  36.551 1 36.431  ? 307  PHE A CG  1 
ATOM   2365 C  CD1 . PHE A 1 289 ? -14.703 9.994  35.599 1 33.768  ? 307  PHE A CD1 1 
ATOM   2366 C  CD2 . PHE A 1 289 ? -14.785 9.305  37.887 1 38.255  ? 307  PHE A CD2 1 
ATOM   2367 C  CE1 . PHE A 1 289 ? -15.114 11.261 35.975 1 33.359  ? 307  PHE A CE1 1 
ATOM   2368 C  CE2 . PHE A 1 289 ? -15.219 10.58  38.253 1 37.254  ? 307  PHE A CE2 1 
ATOM   2369 C  CZ  . PHE A 1 289 ? -15.362 11.556 37.295 1 33.203  ? 307  PHE A CZ  1 
ATOM   2370 N  N   . THR A 1 290 ? -13.978 4.549  35.364 1 39.79   ? 308  THR A N   1 
ATOM   2371 C  CA  . THR A 1 290 ? -13.35  3.481  34.579 1 41.786  ? 308  THR A CA  1 
ATOM   2372 C  C   . THR A 1 290 ? -14.407 2.741  33.775 1 37.059  ? 308  THR A C   1 
ATOM   2373 O  O   . THR A 1 290 ? -14.083 2.302  32.691 1 40.543  ? 308  THR A O   1 
ATOM   2374 C  CB  . THR A 1 290 ? -12.498 2.51   35.39  1 39.724  ? 308  THR A CB  1 
ATOM   2375 O  OG1 . THR A 1 290 ? -13.315 1.911  36.384 1 43.577  ? 308  THR A OG1 1 
ATOM   2376 C  CG2 . THR A 1 290 ? -11.365 3.229  36.096 1 40.372  ? 308  THR A CG2 1 
ATOM   2377 N  N   . SER A 1 291 ? -15.666 2.726  34.25  1 36.875  ? 309  SER A N   1 
ATOM   2378 C  CA  . SER A 1 291 ? -16.78  2.09   33.563 1 32.728  ? 309  SER A CA  1 
ATOM   2379 C  C   . SER A 1 291 ? -17.053 2.777  32.225 1 39.151  ? 309  SER A C   1 
ATOM   2380 O  O   . SER A 1 291 ? -17.658 2.187  31.334 1 37.843  ? 309  SER A O   1 
ATOM   2381 C  CB  . SER A 1 291 ? -18.035 2.107  34.412 1 35.915  ? 309  SER A CB  1 
ATOM   2382 O  OG  . SER A 1 291 ? -18.968 3.108  33.99  1 37.605  ? 309  SER A OG  1 
ATOM   2383 N  N   . MET A 1 292 ? -16.699 4.065  32.118 1 44.209  ? 310  MET A N   1 
ATOM   2384 C  CA  . MET A 1 292 ? -16.93  4.83   30.9   1 42.905  ? 310  MET A CA  1 
ATOM   2385 C  C   . MET A 1 292 ? -15.667 4.815  30.028 1 41.052  ? 310  MET A C   1 
ATOM   2386 O  O   . MET A 1 292 ? -15.58  5.547  29.05  1 37.216  ? 310  MET A O   1 
ATOM   2387 C  CB  . MET A 1 292 ? -17.329 6.278  31.226 1 44.418  ? 310  MET A CB  1 
ATOM   2388 C  CG  . MET A 1 292 ? -18.517 6.433  32.165 1 48.072  ? 310  MET A CG  1 
ATOM   2389 S  SD  . MET A 1 292 ? -18.811 8.148  32.644 1 49.087  ? 310  MET A SD  1 
ATOM   2390 C  CE  . MET A 1 292 ? -19.551 8.684  31.096 1 50.496  ? 310  MET A CE  1 
ATOM   2391 N  N   . ASN A 1 293 ? -14.686 3.967  30.37  1 44.121  ? 311  ASN A N   1 
ATOM   2392 C  CA  . ASN A 1 293 ? -13.453 3.878  29.608 1 47.49   ? 311  ASN A CA  1 
ATOM   2393 C  C   . ASN A 1 293 ? -12.666 5.185  29.774 1 49.059  ? 311  ASN A C   1 
ATOM   2394 O  O   . ASN A 1 293 ? -12.063 5.689  28.835 1 50.32   ? 311  ASN A O   1 
ATOM   2395 C  CB  . ASN A 1 293 ? -13.709 3.487  28.152 1 53.395  ? 311  ASN A CB  1 
ATOM   2396 C  CG  . ASN A 1 293 ? -12.417 2.998  27.516 1 67.434  ? 311  ASN A CG  1 
ATOM   2397 O  OD1 . ASN A 1 293 ? -11.698 2.237  28.165 1 60.895  ? 311  ASN A OD1 1 
ATOM   2398 N  ND2 . ASN A 1 293 ? -12.112 3.466  26.304 1 84.155  ? 311  ASN A ND2 1 
ATOM   2399 N  N   . LEU A 1 294 ? -12.658 5.718  30.996 1 41.482  ? 312  LEU A N   1 
ATOM   2400 C  CA  . LEU A 1 294 ? -11.838 6.857  31.335 1 39.258  ? 312  LEU A CA  1 
ATOM   2401 C  C   . LEU A 1 294 ? -10.793 6.366  32.317 1 37.936  ? 312  LEU A C   1 
ATOM   2402 O  O   . LEU A 1 294 ? -10.752 5.193  32.65  1 47.494  ? 312  LEU A O   1 
ATOM   2403 C  CB  . LEU A 1 294 ? -12.701 7.975  31.925 1 39.327  ? 312  LEU A CB  1 
ATOM   2404 C  CG  . LEU A 1 294 ? -13.605 8.731  30.947 1 38.987  ? 312  LEU A CG  1 
ATOM   2405 C  CD1 . LEU A 1 294 ? -14.495 9.742  31.677 1 37.542  ? 312  LEU A CD1 1 
ATOM   2406 C  CD2 . LEU A 1 294 ? -12.786 9.403  29.868 1 39.824  ? 312  LEU A CD2 1 
ATOM   2407 N  N   . THR A 1 295 ? -9.986  7.282  32.824 1 33.49   ? 313  THR A N   1 
ATOM   2408 C  CA  . THR A 1 295 ? -8.751  6.897  33.454 1 37.602  ? 313  THR A CA  1 
ATOM   2409 C  C   . THR A 1 295 ? -9.007  6.538  34.913 1 41.933  ? 313  THR A C   1 
ATOM   2410 O  O   . THR A 1 295 ? -9.695  7.25   35.646 1 42.947  ? 313  THR A O   1 
ATOM   2411 C  CB  . THR A 1 295 ? -7.732  8.028  33.283 1 36.587  ? 313  THR A CB  1 
ATOM   2412 O  OG1 . THR A 1 295 ? -7.566  8.17   31.873 1 38.245  ? 313  THR A OG1 1 
ATOM   2413 C  CG2 . THR A 1 295 ? -6.42   7.729  33.989 1 36.544  ? 313  THR A CG2 1 
ATOM   2414 N  N   . LYS A 1 296 ? -8.38   5.431  35.308 1 43.528  ? 314  LYS A N   1 
ATOM   2415 C  CA  . LYS A 1 296 ? -8.393  4.919  36.658 1 40.844  ? 314  LYS A CA  1 
ATOM   2416 C  C   . LYS A 1 296 ? -7.545  5.802  37.55  1 36.591  ? 314  LYS A C   1 
ATOM   2417 O  O   . LYS A 1 296 ? -6.524  6.34   37.132 1 38.352  ? 314  LYS A O   1 
ATOM   2418 C  CB  . LYS A 1 296 ? -7.827  3.501  36.543 1 57.946  ? 314  LYS A CB  1 
ATOM   2419 C  CG  . LYS A 1 296 ? -7.446  2.777  37.837 1 74.373  ? 314  LYS A CG  1 
ATOM   2420 C  CD  . LYS A 1 296 ? -6.614  1.51   37.606 1 82.487  ? 314  LYS A CD  1 
ATOM   2421 C  CE  . LYS A 1 296 ? -5.199  1.77   37.173 1 78.616  ? 314  LYS A CE  1 
ATOM   2422 N  NZ  . LYS A 1 296 ? -4.727  0.704  36.284 1 78.853  ? 314  LYS A NZ  1 
ATOM   2423 N  N   . LEU A 1 297 ? -7.943  5.91   38.817 1 36.67   ? 315  LEU A N   1 
ATOM   2424 C  CA  . LEU A 1 297 ? -7.132  6.637  39.773 1 35.001  ? 315  LEU A CA  1 
ATOM   2425 C  C   . LEU A 1 297 ? -5.768  5.965  39.908 1 39.41   ? 315  LEU A C   1 
ATOM   2426 O  O   . LEU A 1 297 ? -5.644  4.769  40.108 1 47.808  ? 315  LEU A O   1 
ATOM   2427 C  CB  . LEU A 1 297 ? -7.803  6.77   41.139 1 33.616  ? 315  LEU A CB  1 
ATOM   2428 C  CG  . LEU A 1 297 ? -9.118  7.56   41.152 1 37.292  ? 315  LEU A CG  1 
ATOM   2429 C  CD1 . LEU A 1 297 ? -9.684  7.636  42.559 1 36.96   ? 315  LEU A CD1 1 
ATOM   2430 C  CD2 . LEU A 1 297 ? -8.916  8.955  40.609 1 34.603  ? 315  LEU A CD2 1 
ATOM   2431 N  N   . PRO A 1 298 ? -4.682  6.737  39.88  1 41.106  ? 316  PRO A N   1 
ATOM   2432 C  CA  . PRO A 1 298 ? -3.372  6.185  40.163 1 39.356  ? 316  PRO A CA  1 
ATOM   2433 C  C   . PRO A 1 298 ? -3.154  5.905  41.638 1 39.029  ? 316  PRO A C   1 
ATOM   2434 O  O   . PRO A 1 298 ? -3.878  6.404  42.47  1 43.172  ? 316  PRO A O   1 
ATOM   2435 C  CB  . PRO A 1 298 ? -2.431  7.309  39.725 1 42.361  ? 316  PRO A CB  1 
ATOM   2436 C  CG  . PRO A 1 298 ? -3.255  8.57   39.924 1 43.519  ? 316  PRO A CG  1 
ATOM   2437 C  CD  . PRO A 1 298 ? -4.673  8.186  39.6   1 44.101  ? 316  PRO A CD  1 
ATOM   2438 N  N   . GLN A 1 299 ? -2.057  5.23   41.953 1 36.417  ? 317  GLN A N   1 
ATOM   2439 C  CA  . GLN A 1 299 ? -1.775  4.791  43.305 1 37.531  ? 317  GLN A CA  1 
ATOM   2440 C  C   . GLN A 1 299 ? -1.45   5.971  44.222 1 36.967  ? 317  GLN A C   1 
ATOM   2441 O  O   . GLN A 1 299 ? -1.67   5.896  45.436 1 36.606  ? 317  GLN A O   1 
ATOM   2442 C  CB  . GLN A 1 299 ? -0.627  3.771  43.222 1 42.93   ? 317  GLN A CB  1 
ATOM   2443 C  CG  . GLN A 1 299 ? -0.329  3.028  44.52  1 44.503  ? 317  GLN A CG  1 
ATOM   2444 C  CD  . GLN A 1 299 ? -1.535  2.25   44.987 1 47.049  ? 317  GLN A CD  1 
ATOM   2445 O  OE1 . GLN A 1 299 ? -2.236  1.641  44.162 1 38.532  ? 317  GLN A OE1 1 
ATOM   2446 N  NE2 . GLN A 1 299 ? -1.833  2.365  46.281 1 41.835  ? 317  GLN A NE2 1 
ATOM   2447 N  N   . ASP A 1 300 ? -0.896  7.057  43.666 1 38.441  ? 318  ASP A N   1 
ATOM   2448 C  CA  . ASP A 1 300 ? -0.56   8.227  44.467 1 39.665  ? 318  ASP A CA  1 
ATOM   2449 C  C   . ASP A 1 300 ? -1.811  8.81   45.123 1 34.869  ? 318  ASP A C   1 
ATOM   2450 O  O   . ASP A 1 300 ? -1.756  9.326  46.247 1 34.683  ? 318  ASP A O   1 
ATOM   2451 C  CB  . ASP A 1 300 ? 0.181   9.256  43.63  1 54.351  ? 318  ASP A CB  1 
ATOM   2452 C  CG  . ASP A 1 300 ? 1.651   8.929  43.381 1 68.808  ? 318  ASP A CG  1 
ATOM   2453 O  OD1 . ASP A 1 300 ? 2.355   8.638  44.384 1 59.252  ? 318  ASP A OD1 1 
ATOM   2454 O  OD2 . ASP A 1 300 ? 2.076   8.955  42.191 1 79.778  ? 318  ASP A OD2 1 
ATOM   2455 N  N   . PHE A 1 301 ? -2.923  8.704  44.388 1 31.076  ? 319  PHE A N   1 
ATOM   2456 C  CA  . PHE A 1 301 ? -4.22   9.176  44.823 1 36.537  ? 319  PHE A CA  1 
ATOM   2457 C  C   . PHE A 1 301 ? -4.565  8.468  46.124 1 37.086  ? 319  PHE A C   1 
ATOM   2458 O  O   . PHE A 1 301 ? -4.818  9.142  47.126 1 36.031  ? 319  PHE A O   1 
ATOM   2459 C  CB  . PHE A 1 301 ? -5.317  9.022  43.755 1 36.282  ? 319  PHE A CB  1 
ATOM   2460 C  CG  . PHE A 1 301 ? -6.633  9.541  44.295 1 40.565  ? 319  PHE A CG  1 
ATOM   2461 C  CD1 . PHE A 1 301 ? -7.504  8.689  44.963 1 40.861  ? 319  PHE A CD1 1 
ATOM   2462 C  CD2 . PHE A 1 301 ? -6.939  10.896 44.24  1 41.635  ? 319  PHE A CD2 1 
ATOM   2463 C  CE1 . PHE A 1 301 ? -8.682  9.166  45.5   1 39.707  ? 319  PHE A CE1 1 
ATOM   2464 C  CE2 . PHE A 1 301 ? -8.11   11.374 44.797 1 40.812  ? 319  PHE A CE2 1 
ATOM   2465 C  CZ  . PHE A 1 301 ? -8.98   10.508 45.42  1 41.126  ? 319  PHE A CZ  1 
ATOM   2466 N  N   . TRP A 1 302 ? -4.54   7.125  46.083 1 34.375  ? 320  TRP A N   1 
ATOM   2467 C  CA  . TRP A 1 302 ? -4.909  6.316  47.232 1 31.059  ? 320  TRP A CA  1 
ATOM   2468 C  C   . TRP A 1 302 ? -3.888  6.512  48.343 1 32.629  ? 320  TRP A C   1 
ATOM   2469 O  O   . TRP A 1 302 ? -4.265  6.537  49.506 1 35.308  ? 320  TRP A O   1 
ATOM   2470 C  CB  . TRP A 1 302 ? -5.055  4.845  46.832 1 29.046  ? 320  TRP A CB  1 
ATOM   2471 C  CG  . TRP A 1 302 ? -6.093  4.629  45.758 1 30.339  ? 320  TRP A CG  1 
ATOM   2472 C  CD1 . TRP A 1 302 ? -5.897  4.197  44.473 1 31.048  ? 320  TRP A CD1 1 
ATOM   2473 C  CD2 . TRP A 1 302 ? -7.518  4.826  45.893 1 30.602  ? 320  TRP A CD2 1 
ATOM   2474 N  NE1 . TRP A 1 302 ? -7.087  4.104  43.795 1 31.554  ? 320  TRP A NE1 1 
ATOM   2475 C  CE2 . TRP A 1 302 ? -8.101  4.485  44.64  1 31.817  ? 320  TRP A CE2 1 
ATOM   2476 C  CE3 . TRP A 1 302 ? -8.345  5.248  46.948 1 29.128  ? 320  TRP A CE3 1 
ATOM   2477 C  CZ2 . TRP A 1 302 ? -9.477  4.559  44.415 1 29.063  ? 320  TRP A CZ2 1 
ATOM   2478 C  CZ3 . TRP A 1 302 ? -9.705  5.301  46.731 1 29.123  ? 320  TRP A CZ3 1 
ATOM   2479 C  CH2 . TRP A 1 302 ? -10.256 4.953  45.482 1 27.759  ? 320  TRP A CH2 1 
ATOM   2480 N  N   . ASP A 1 303 ? -2.598  6.723  48.012 1 33.713  ? 321  ASP A N   1 
ATOM   2481 C  CA  . ASP A 1 303 ? -1.596  6.803  49.072 1 37.597  ? 321  ASP A CA  1 
ATOM   2482 C  C   . ASP A 1 303 ? -1.614  8.153  49.769 1 36.671  ? 321  ASP A C   1 
ATOM   2483 O  O   . ASP A 1 303 ? -1.306  8.211  50.957 1 39.16   ? 321  ASP A O   1 
ATOM   2484 C  CB  . ASP A 1 303 ? -0.163  6.52   48.621 1 42.663  ? 321  ASP A CB  1 
ATOM   2485 C  CG  . ASP A 1 303 ? 0.115   5.134  48.042 1 48.204  ? 321  ASP A CG  1 
ATOM   2486 O  OD1 . ASP A 1 303 ? -0.478  4.158  48.545 1 51.497  ? 321  ASP A OD1 1 
ATOM   2487 O  OD2 . ASP A 1 303 ? 0.916   5.037  47.07  1 47.304  ? 321  ASP A OD2 1 
ATOM   2488 N  N   . LYS A 1 304 ? -1.845  9.247  49.018 1 38.293  ? 322  LYS A N   1 
ATOM   2489 C  CA  . LYS A 1 304 ? -1.642  10.582 49.579 1 42      ? 322  LYS A CA  1 
ATOM   2490 C  C   . LYS A 1 304 ? -2.944  11.333 49.901 1 37.971  ? 322  LYS A C   1 
ATOM   2491 O  O   . LYS A 1 304 ? -2.875  12.324 50.632 1 34.605  ? 322  LYS A O   1 
ATOM   2492 C  CB  . LYS A 1 304 ? -0.74   11.402 48.658 1 47.591  ? 322  LYS A CB  1 
ATOM   2493 C  CG  . LYS A 1 304 ? 0.724   11.008 48.666 1 50.398  ? 322  LYS A CG  1 
ATOM   2494 C  CD  . LYS A 1 304 ? 1.414   11.492 47.405 1 55.443  ? 322  LYS A CD  1 
ATOM   2495 C  CE  . LYS A 1 304 ? 2.897   11.354 47.413 1 63.404  ? 322  LYS A CE  1 
ATOM   2496 N  NZ  . LYS A 1 304 ? 3.377   11.519 46.036 1 64.801  ? 322  LYS A NZ  1 
ATOM   2497 N  N   . SER A 1 305 ? -4.112  10.883 49.393 1 32.051  ? 323  SER A N   1 
ATOM   2498 C  CA  . SER A 1 305 ? -5.332  11.647 49.611 1 32.902  ? 323  SER A CA  1 
ATOM   2499 C  C   . SER A 1 305 ? -5.7    11.593 51.09  1 33.55   ? 323  SER A C   1 
ATOM   2500 O  O   . SER A 1 305 ? -5.215  10.739 51.827 1 34.252  ? 323  SER A O   1 
ATOM   2501 C  CB  . SER A 1 305 ? -6.468  11.219 48.747 1 31.669  ? 323  SER A CB  1 
ATOM   2502 O  OG  . SER A 1 305 ? -6.211  11.471 47.367 1 31.612  ? 323  SER A OG  1 
ATOM   2503 N  N   . ILE A 1 306 ? -6.455  12.596 51.53  1 33.911  ? 324  ILE A N   1 
ATOM   2504 C  CA  . ILE A 1 306 ? -7.097  12.576 52.83  1 35.898  ? 324  ILE A CA  1 
ATOM   2505 C  C   . ILE A 1 306 ? -8.602  12.534 52.604 1 35.002  ? 324  ILE A C   1 
ATOM   2506 O  O   . ILE A 1 306 ? -9.152  13.534 52.157 1 35.622  ? 324  ILE A O   1 
ATOM   2507 C  CB  . ILE A 1 306 ? -6.707  13.816 53.632 1 35.343  ? 324  ILE A CB  1 
ATOM   2508 C  CG1 . ILE A 1 306 ? -5.227  13.812 53.914 1 36.513  ? 324  ILE A CG1 1 
ATOM   2509 C  CG2 . ILE A 1 306 ? -7.544  13.893 54.906 1 37.245  ? 324  ILE A CG2 1 
ATOM   2510 C  CD1 . ILE A 1 306 ? -4.743  14.991 54.736 1 38.215  ? 324  ILE A CD1 1 
ATOM   2511 N  N   . ILE A 1 307 ? -9.233  11.386 52.885 1 33.75   ? 325  ILE A N   1 
ATOM   2512 C  CA  . ILE A 1 307 ? -10.64  11.164 52.579 1 33.682  ? 325  ILE A CA  1 
ATOM   2513 C  C   . ILE A 1 307 ? -11.458 11.006 53.86  1 32.875  ? 325  ILE A C   1 
ATOM   2514 O  O   . ILE A 1 307 ? -12.64  10.72  53.772 1 35.857  ? 325  ILE A O   1 
ATOM   2515 C  CB  . ILE A 1 307 ? -10.844 9.969  51.632 1 38.277  ? 325  ILE A CB  1 
ATOM   2516 C  CG1 . ILE A 1 307 ? -10.378 8.631  52.259 1 38.012  ? 325  ILE A CG1 1 
ATOM   2517 C  CG2 . ILE A 1 307 ? -10.186 10.209 50.272 1 37.213  ? 325  ILE A CG2 1 
ATOM   2518 C  CD1 . ILE A 1 307 ? -10.944 7.41   51.545 1 37.954  ? 325  ILE A CD1 1 
ATOM   2519 N  N   . GLU A 1 308 ? -10.884 11.334 55.019 1 35.29   ? 326  GLU A N   1 
ATOM   2520 C  CA  . GLU A 1 308 ? -11.586 11.261 56.289 1 39.395  ? 326  GLU A CA  1 
ATOM   2521 C  C   . GLU A 1 308 ? -11.056 12.348 57.222 1 35.749  ? 326  GLU A C   1 
ATOM   2522 O  O   . GLU A 1 308 ? -9.886  12.718 57.189 1 34.453  ? 326  GLU A O   1 
ATOM   2523 C  CB  . GLU A 1 308 ? -11.329 9.861  56.846 1 53.274  ? 326  GLU A CB  1 
ATOM   2524 C  CG  . GLU A 1 308 ? -12.533 9.276  57.574 1 74.201  ? 326  GLU A CG  1 
ATOM   2525 C  CD  . GLU A 1 308 ? -12.441 7.787  57.87  1 85.878  ? 326  GLU A CD  1 
ATOM   2526 O  OE1 . GLU A 1 308 ? -11.942 7.018  57.006 1 82.576  ? 326  GLU A OE1 1 
ATOM   2527 O  OE2 . GLU A 1 308 ? -12.93  7.407  58.961 1 87.499  ? 326  GLU A OE2 1 
ATOM   2528 N  N   . LYS A 1 309 ? -11.924 12.91  58.046 1 36.408  ? 327  LYS A N   1 
ATOM   2529 C  CA  . LYS A 1 309 ? -11.489 13.983 58.92  1 38.217  ? 327  LYS A CA  1 
ATOM   2530 C  C   . LYS A 1 309 ? -10.468 13.399 59.889 1 39.097  ? 327  LYS A C   1 
ATOM   2531 O  O   . LYS A 1 309 ? -10.79  12.444 60.593 1 42.413  ? 327  LYS A O   1 
ATOM   2532 C  CB  . LYS A 1 309 ? -12.656 14.648 59.661 1 39.062  ? 327  LYS A CB  1 
ATOM   2533 C  CG  . LYS A 1 309 ? -12.247 15.925 60.387 1 40.738  ? 327  LYS A CG  1 
ATOM   2534 C  CD  . LYS A 1 309 ? -13.358 16.732 61.04  1 45.245  ? 327  LYS A CD  1 
ATOM   2535 C  CE  . LYS A 1 309 ? -12.809 17.904 61.812 1 48.306  ? 327  LYS A CE  1 
ATOM   2536 N  NZ  . LYS A 1 309 ? -13.831 18.678 62.528 1 52.614  ? 327  LYS A NZ  1 
ATOM   2537 N  N   . PRO A 1 310 ? -9.223  13.929 59.941 1 44.576  ? 328  PRO A N   1 
ATOM   2538 C  CA  . PRO A 1 310 ? -8.254  13.537 60.957 1 49.008  ? 328  PRO A CA  1 
ATOM   2539 C  C   . PRO A 1 310 ? -8.85   13.548 62.358 1 47.504  ? 328  PRO A C   1 
ATOM   2540 O  O   . PRO A 1 310 ? -9.691  14.391 62.638 1 50.706  ? 328  PRO A O   1 
ATOM   2541 C  CB  . PRO A 1 310 ? -7.159  14.601 60.846 1 50.369  ? 328  PRO A CB  1 
ATOM   2542 C  CG  . PRO A 1 310 ? -7.224  14.965 59.373 1 49.929  ? 328  PRO A CG  1 
ATOM   2543 C  CD  . PRO A 1 310 ? -8.69   14.976 59.054 1 48.719  ? 328  PRO A CD  1 
ATOM   2544 N  N   . THR A 1 311 ? -8.41   12.615 63.214 1 55.795  ? 329  THR A N   1 
ATOM   2545 C  CA  . THR A 1 311 ? -8.955  12.461 64.558 1 59.963  ? 329  THR A CA  1 
ATOM   2546 C  C   . THR A 1 311 ? -7.939  12.897 65.622 1 59.296  ? 329  THR A C   1 
ATOM   2547 O  O   . THR A 1 311 ? -8.036  12.45  66.759 1 61.186  ? 329  THR A O   1 
ATOM   2548 C  CB  . THR A 1 311 ? -9.399  11.006 64.768 1 62.447  ? 329  THR A CB  1 
ATOM   2549 O  OG1 . THR A 1 311 ? -8.212  10.23  64.842 1 62.707  ? 329  THR A OG1 1 
ATOM   2550 C  CG2 . THR A 1 311 ? -10.226 10.428 63.629 1 64.353  ? 329  THR A CG2 1 
ATOM   2551 N  N   . ASP A 1 312 ? -6.99   13.788 65.284 1 59.294  ? 330  ASP A N   1 
ATOM   2552 C  CA  . ASP A 1 312 ? -5.94   14.186 66.218 1 60.569  ? 330  ASP A CA  1 
ATOM   2553 C  C   . ASP A 1 312 ? -6.124  15.628 66.7   1 69.321  ? 330  ASP A C   1 
ATOM   2554 O  O   . ASP A 1 312 ? -5.177  16.215 67.21  1 70.023  ? 330  ASP A O   1 
ATOM   2555 C  CB  . ASP A 1 312 ? -4.551  13.907 65.655 1 62.093  ? 330  ASP A CB  1 
ATOM   2556 C  CG  . ASP A 1 312 ? -4.197  14.562 64.324 1 68.438  ? 330  ASP A CG  1 
ATOM   2557 O  OD1 . ASP A 1 312 ? -4.982  15.412 63.866 1 73.198  ? 330  ASP A OD1 1 
ATOM   2558 O  OD2 . ASP A 1 312 ? -3.133  14.221 63.751 1 65.753  ? 330  ASP A OD2 1 
ATOM   2559 N  N   . GLY A 1 313 ? -7.331  16.2   66.535 1 73.818  ? 331  GLY A N   1 
ATOM   2560 C  CA  . GLY A 1 313 ? -7.704  17.468 67.155 1 72.878  ? 331  GLY A CA  1 
ATOM   2561 C  C   . GLY A 1 313 ? -6.943  18.674 66.595 1 71.096  ? 331  GLY A C   1 
ATOM   2562 O  O   . GLY A 1 313 ? -6.972  19.757 67.189 1 63.59   ? 331  GLY A O   1 
ATOM   2563 N  N   . ARG A 1 314 ? -6.264  18.473 65.456 1 63.483  ? 332  ARG A N   1 
ATOM   2564 C  CA  . ARG A 1 314 ? -5.577  19.542 64.755 1 56.649  ? 332  ARG A CA  1 
ATOM   2565 C  C   . ARG A 1 314 ? -6.569  20.345 63.926 1 51.819  ? 332  ARG A C   1 
ATOM   2566 O  O   . ARG A 1 314 ? -7.652  19.848 63.622 1 50.76   ? 332  ARG A O   1 
ATOM   2567 C  CB  . ARG A 1 314 ? -4.587  19.048 63.7   1 52.347  ? 332  ARG A CB  1 
ATOM   2568 C  CG  . ARG A 1 314 ? -5.173  18.516 62.394 1 51.745  ? 332  ARG A CG  1 
ATOM   2569 C  CD  . ARG A 1 314 ? -4.007  17.883 61.66  1 53.723  ? 332  ARG A CD  1 
ATOM   2570 N  NE  . ARG A 1 314 ? -4.273  17.144 60.427 1 52.896  ? 332  ARG A NE  1 
ATOM   2571 C  CZ  . ARG A 1 314 ? -3.828  15.916 60.184 1 52.651  ? 332  ARG A CZ  1 
ATOM   2572 N  NH1 . ARG A 1 314 ? -3.534  15.087 61.162 1 53.678  ? 332  ARG A NH1 1 
ATOM   2573 N  NH2 . ARG A 1 314 ? -3.741  15.483 58.944 1 58.903  ? 332  ARG A NH2 1 
ATOM   2574 N  N   . ASP A 1 315 ? -6.123  21.545 63.524 1 44.884  ? 333  ASP A N   1 
ATOM   2575 C  CA  . ASP A 1 315 ? -6.876  22.45  62.677 1 44.492  ? 333  ASP A CA  1 
ATOM   2576 C  C   . ASP A 1 315 ? -6.528  22.175 61.216 1 41.145  ? 333  ASP A C   1 
ATOM   2577 O  O   . ASP A 1 315 ? -5.377  21.909 60.903 1 37.665  ? 333  ASP A O   1 
ATOM   2578 C  CB  . ASP A 1 315 ? -6.676  23.878 63.143 1 45.472  ? 333  ASP A CB  1 
ATOM   2579 C  CG  . ASP A 1 315 ? -7.401  24.204 64.44  1 54.389  ? 333  ASP A CG  1 
ATOM   2580 O  OD1 . ASP A 1 315 ? -8.635  23.936 64.512 1 53.852  ? 333  ASP A OD1 1 
ATOM   2581 O  OD2 . ASP A 1 315 ? -6.739  24.739 65.351 1 56.073  ? 333  ASP A OD2 1 
ATOM   2582 N  N   . LEU A 1 316 ? -7.551  22.159 60.351 1 40.013  ? 334  LEU A N   1 
ATOM   2583 C  CA  . LEU A 1 316 ? -7.375  21.985 58.916 1 40.081  ? 334  LEU A CA  1 
ATOM   2584 C  C   . LEU A 1 316 ? -8.57   22.622 58.207 1 37.613  ? 334  LEU A C   1 
ATOM   2585 O  O   . LEU A 1 316 ? -9.543  23.001 58.84  1 34.642  ? 334  LEU A O   1 
ATOM   2586 C  CB  . LEU A 1 316 ? -7.21   20.524 58.492 1 38.387  ? 334  LEU A CB  1 
ATOM   2587 C  CG  . LEU A 1 316 ? -8.484  19.674 58.479 1 42.952  ? 334  LEU A CG  1 
ATOM   2588 C  CD1 . LEU A 1 316 ? -8.332  18.433 57.623 1 41.601  ? 334  LEU A CD1 1 
ATOM   2589 C  CD2 . LEU A 1 316 ? -8.882  19.28  59.897 1 44.205  ? 334  LEU A CD2 1 
ATOM   2590 N  N   . VAL A 1 317 ? -8.449  22.768 56.889 1 35.549  ? 335  VAL A N   1 
ATOM   2591 C  CA  . VAL A 1 317 ? -9.533  23.191 56.038 1 36.973  ? 335  VAL A CA  1 
ATOM   2592 C  C   . VAL A 1 317 ? -10.307 21.946 55.627 1 37.335  ? 335  VAL A C   1 
ATOM   2593 O  O   . VAL A 1 317 ? -9.807  21.168 54.81  1 38.448  ? 335  VAL A O   1 
ATOM   2594 C  CB  . VAL A 1 317 ? -8.992  23.914 54.793 1 37.166  ? 335  VAL A CB  1 
ATOM   2595 C  CG1 . VAL A 1 317 ? -10.116 24.245 53.826 1 35.446  ? 335  VAL A CG1 1 
ATOM   2596 C  CG2 . VAL A 1 317 ? -8.191  25.155 55.157 1 38.616  ? 335  VAL A CG2 1 
ATOM   2597 N  N   . CYS A 1 318 ? -11.543 21.812 56.126 1 38.834  ? 336  CYS A N   1 
ATOM   2598 C  CA  . CYS A 1 318 ? -12.37  20.67  55.768 1 46.978  ? 336  CYS A CA  1 
ATOM   2599 C  C   . CYS A 1 318 ? -13.156 20.877 54.467 1 45.18   ? 336  CYS A C   1 
ATOM   2600 O  O   . CYS A 1 318 ? -13.651 19.903 53.901 1 47.842  ? 336  CYS A O   1 
ATOM   2601 C  CB  . CYS A 1 318 ? -13.257 20.241 56.933 1 54.625  ? 336  CYS A CB  1 
ATOM   2602 S  SG  . CYS A 1 318 ? -12.57  18.87  57.914 1 54.797  ? 336  CYS A SG  1 
ATOM   2603 N  N   . HIS A 1 319 ? -13.235 22.107 53.947 1 39.806  ? 337  HIS A N   1 
ATOM   2604 C  CA  . HIS A 1 319 ? -13.95  22.332 52.695 1 36.108  ? 337  HIS A CA  1 
ATOM   2605 C  C   . HIS A 1 319 ? -13.322 21.463 51.607 1 32.98   ? 337  HIS A C   1 
ATOM   2606 O  O   . HIS A 1 319 ? -12.135 21.565 51.35  1 35.435  ? 337  HIS A O   1 
ATOM   2607 C  CB  . HIS A 1 319 ? -14.014 23.823 52.305 1 35.91   ? 337  HIS A CB  1 
ATOM   2608 C  CG  . HIS A 1 319 ? -15.007 24.076 51.223 1 36.514  ? 337  HIS A CG  1 
ATOM   2609 N  ND1 . HIS A 1 319 ? -16.349 24.306 51.472 1 37.26   ? 337  HIS A ND1 1 
ATOM   2610 C  CD2 . HIS A 1 319 ? -14.859 24.03  49.878 1 32.804  ? 337  HIS A CD2 1 
ATOM   2611 C  CE1 . HIS A 1 319 ? -16.986 24.409 50.307 1 38.591  ? 337  HIS A CE1 1 
ATOM   2612 N  NE2 . HIS A 1 319 ? -16.091 24.241 49.328 1 35.49   ? 337  HIS A NE2 1 
ATOM   2613 N  N   . ALA A 1 320 ? -14.131 20.607 50.985 1 29.679  ? 338  ALA A N   1 
ATOM   2614 C  CA  . ALA A 1 320 ? -13.674 19.572 50.073 1 30.583  ? 338  ALA A CA  1 
ATOM   2615 C  C   . ALA A 1 320 ? -13.001 20.175 48.847 1 33.55   ? 338  ALA A C   1 
ATOM   2616 O  O   . ALA A 1 320 ? -13.506 21.151 48.296 1 34.509  ? 338  ALA A O   1 
ATOM   2617 C  CB  . ALA A 1 320 ? -14.841 18.717 49.657 1 30.453  ? 338  ALA A CB  1 
ATOM   2618 N  N   . SER A 1 321 ? -11.886 19.554 48.419 1 33.682  ? 339  SER A N   1 
ATOM   2619 C  CA  . SER A 1 321 ? -11.077 20.073 47.337 1 31.126  ? 339  SER A CA  1 
ATOM   2620 C  C   . SER A 1 321 ? -10.254 18.977 46.65  1 34.182  ? 339  SER A C   1 
ATOM   2621 O  O   . SER A 1 321 ? -9.997  17.922 47.22  1 33.659  ? 339  SER A O   1 
ATOM   2622 C  CB  . SER A 1 321 ? -10.199 21.176 47.85  1 31.777  ? 339  SER A CB  1 
ATOM   2623 O  OG  . SER A 1 321 ? -9.283  20.722 48.836 1 31.386  ? 339  SER A OG  1 
ATOM   2624 N  N   . ALA A 1 322 ? -9.821  19.292 45.419 1 34.306  ? 340  ALA A N   1 
ATOM   2625 C  CA  . ALA A 1 322 ? -9.034  18.446 44.532 1 32.86   ? 340  ALA A CA  1 
ATOM   2626 C  C   . ALA A 1 322 ? -7.758  19.173 44.077 1 37.682  ? 340  ALA A C   1 
ATOM   2627 O  O   . ALA A 1 322 ? -7.81   20.308 43.594 1 35.679  ? 340  ALA A O   1 
ATOM   2628 C  CB  . ALA A 1 322 ? -9.878  18.092 43.342 1 28.259  ? 340  ALA A CB  1 
ATOM   2629 N  N   . TRP A 1 323 ? -6.625  18.465 44.131 1 34.301  ? 341  TRP A N   1 
ATOM   2630 C  CA  . TRP A 1 323 ? -5.309  19.06  43.977 1 33.595  ? 341  TRP A CA  1 
ATOM   2631 C  C   . TRP A 1 323 ? -4.525  18.37  42.866 1 35.059  ? 341  TRP A C   1 
ATOM   2632 O  O   . TRP A 1 323 ? -4.454  17.142 42.831 1 30.678  ? 341  TRP A O   1 
ATOM   2633 C  CB  . TRP A 1 323 ? -4.549  18.926 45.291 1 31.899  ? 341  TRP A CB  1 
ATOM   2634 C  CG  . TRP A 1 323 ? -5.164  19.686 46.422 1 29.457  ? 341  TRP A CG  1 
ATOM   2635 C  CD1 . TRP A 1 323 ? -6.322  19.418 47.072 1 32.936  ? 341  TRP A CD1 1 
ATOM   2636 C  CD2 . TRP A 1 323 ? -4.589  20.815 47.088 1 34.672  ? 341  TRP A CD2 1 
ATOM   2637 N  NE1 . TRP A 1 323 ? -6.518  20.302 48.1   1 35.026  ? 341  TRP A NE1 1 
ATOM   2638 C  CE2 . TRP A 1 323 ? -5.477  21.18  48.123 1 34.605  ? 341  TRP A CE2 1 
ATOM   2639 C  CE3 . TRP A 1 323 ? -3.418  21.546 46.907 1 36.063  ? 341  TRP A CE3 1 
ATOM   2640 C  CZ2 . TRP A 1 323 ? -5.226  22.243 48.973 1 36.077  ? 341  TRP A CZ2 1 
ATOM   2641 C  CZ3 . TRP A 1 323 ? -3.181  22.614 47.738 1 39.697  ? 341  TRP A CZ3 1 
ATOM   2642 C  CH2 . TRP A 1 323 ? -4.068  22.95  48.758 1 38.597  ? 341  TRP A CH2 1 
ATOM   2643 N  N   . ASP A 1 324 ? -3.96   19.183 41.965 1 32.651  ? 342  ASP A N   1 
ATOM   2644 C  CA  . ASP A 1 324 ? -3.058  18.725 40.92  1 33.634  ? 342  ASP A CA  1 
ATOM   2645 C  C   . ASP A 1 324 ? -1.645  19.126 41.34  1 36.79   ? 342  ASP A C   1 
ATOM   2646 O  O   . ASP A 1 324 ? -1.441  20.274 41.735 1 32.152  ? 342  ASP A O   1 
ATOM   2647 C  CB  . ASP A 1 324 ? -3.387  19.368 39.582 1 31.888  ? 342  ASP A CB  1 
ATOM   2648 C  CG  . ASP A 1 324 ? -2.694  18.744 38.377 1 36.128  ? 342  ASP A CG  1 
ATOM   2649 O  OD1 . ASP A 1 324 ? -1.791  17.905 38.605 1 37.694  ? 342  ASP A OD1 1 
ATOM   2650 O  OD2 . ASP A 1 324 ? -3.098  19.052 37.222 1 31.035  ? 342  ASP A OD2 1 
ATOM   2651 N  N   . PHE A 1 325 ? -0.68   18.191 41.282 1 35.79   ? 343  PHE A N   1 
ATOM   2652 C  CA  . PHE A 1 325 ? 0.672   18.483 41.746 1 32.866  ? 343  PHE A CA  1 
ATOM   2653 C  C   . PHE A 1 325 ? 1.618   18.727 40.582 1 32.596  ? 343  PHE A C   1 
ATOM   2654 O  O   . PHE A 1 325 ? 2.755   19.132 40.822 1 37.9    ? 343  PHE A O   1 
ATOM   2655 C  CB  . PHE A 1 325 ? 1.191   17.408 42.698 1 31.976  ? 343  PHE A CB  1 
ATOM   2656 C  CG  . PHE A 1 325 ? 0.524   17.614 44.039 1 31.538  ? 343  PHE A CG  1 
ATOM   2657 C  CD1 . PHE A 1 325 ? -0.783  17.185 44.249 1 30.835  ? 343  PHE A CD1 1 
ATOM   2658 C  CD2 . PHE A 1 325 ? 1.174   18.293 45.053 1 31.035  ? 343  PHE A CD2 1 
ATOM   2659 C  CE1 . PHE A 1 325 ? -1.395  17.393 45.477 1 28.411  ? 343  PHE A CE1 1 
ATOM   2660 C  CE2 . PHE A 1 325 ? 0.554   18.499 46.278 1 31.54   ? 343  PHE A CE2 1 
ATOM   2661 C  CZ  . PHE A 1 325 ? -0.737  18.057 46.484 1 28.37   ? 343  PHE A CZ  1 
ATOM   2662 N  N   . TYR A 1 326 ? 1.125   18.535 39.353 1 29.736  ? 344  TYR A N   1 
ATOM   2663 C  CA  . TYR A 1 326 ? 1.786   19.025 38.147 1 36.341  ? 344  TYR A CA  1 
ATOM   2664 C  C   . TYR A 1 326 ? 3.004   18.167 37.785 1 33.599  ? 344  TYR A C   1 
ATOM   2665 O  O   . TYR A 1 326 ? 3.871   18.613 37.063 1 34.992  ? 344  TYR A O   1 
ATOM   2666 C  CB  . TYR A 1 326 ? 2.126   20.519 38.28  1 34.129  ? 344  TYR A CB  1 
ATOM   2667 C  CG  . TYR A 1 326 ? 0.905   21.424 38.251 1 37.921  ? 344  TYR A CG  1 
ATOM   2668 C  CD1 . TYR A 1 326 ? 0.168   21.591 37.075 1 44.167  ? 344  TYR A CD1 1 
ATOM   2669 C  CD2 . TYR A 1 326 ? 0.473   22.103 39.381 1 41.296  ? 344  TYR A CD2 1 
ATOM   2670 C  CE1 . TYR A 1 326 ? -0.961  22.395 37.025 1 43.846  ? 344  TYR A CE1 1 
ATOM   2671 C  CE2 . TYR A 1 326 ? -0.655  22.915 39.345 1 45.217  ? 344  TYR A CE2 1 
ATOM   2672 C  CZ  . TYR A 1 326 ? -1.372  23.058 38.169 1 49.102  ? 344  TYR A CZ  1 
ATOM   2673 O  OH  . TYR A 1 326 ? -2.474  23.858 38.146 1 62.092  ? 344  TYR A OH  1 
ATOM   2674 N  N   . LEU A 1 327 ? 3.02    16.914 38.221 1 36.945  ? 345  LEU A N   1 
ATOM   2675 C  CA  . LEU A 1 327 ? 3.997   15.93  37.794 1 37.641  ? 345  LEU A CA  1 
ATOM   2676 C  C   . LEU A 1 327 ? 3.262   14.948 36.894 1 37.628  ? 345  LEU A C   1 
ATOM   2677 O  O   . LEU A 1 327 ? 2.569   15.344 35.952 1 38.2    ? 345  LEU A O   1 
ATOM   2678 C  CB  . LEU A 1 327 ? 4.635   15.245 39.012 1 39.767  ? 345  LEU A CB  1 
ATOM   2679 C  CG  . LEU A 1 327 ? 5.259   16.166 40.071 1 39.861  ? 345  LEU A CG  1 
ATOM   2680 C  CD1 . LEU A 1 327 ? 5.826   15.416 41.275 1 42.362  ? 345  LEU A CD1 1 
ATOM   2681 C  CD2 . LEU A 1 327 ? 6.335   17.041 39.454 1 38.293  ? 345  LEU A CD2 1 
ATOM   2682 N  N   . ILE A 1 328 ? 3.471   13.657 37.137 1 37.199  ? 346  ILE A N   1 
ATOM   2683 C  CA  . ILE A 1 328 ? 2.689   12.641 36.466 1 41.182  ? 346  ILE A CA  1 
ATOM   2684 C  C   . ILE A 1 328 ? 1.988   11.865 37.573 1 40.518  ? 346  ILE A C   1 
ATOM   2685 O  O   . ILE A 1 328 ? 2.639   11.46  38.538 1 43.398  ? 346  ILE A O   1 
ATOM   2686 C  CB  . ILE A 1 328 ? 3.567   11.772 35.547 1 44.295  ? 346  ILE A CB  1 
ATOM   2687 C  CG1 . ILE A 1 328 ? 4.29    12.651 34.524 1 46.357  ? 346  ILE A CG1 1 
ATOM   2688 C  CG2 . ILE A 1 328 ? 2.754   10.654 34.866 1 41.46   ? 346  ILE A CG2 1 
ATOM   2689 C  CD1 . ILE A 1 328 ? 5.482   11.999 33.838 1 48.636  ? 346  ILE A CD1 1 
ATOM   2690 N  N   . ASP A 1 329 ? 0.649   11.824 37.501 1 39.447  ? 347  ASP A N   1 
ATOM   2691 C  CA  . ASP A 1 329 ? -0.145  10.899 38.302 1 42.532  ? 347  ASP A CA  1 
ATOM   2692 C  C   . ASP A 1 329 ? -0.131  11.285 39.781 1 38.539  ? 347  ASP A C   1 
ATOM   2693 O  O   . ASP A 1 329 ? -0.603  10.498 40.594 1 41.207  ? 347  ASP A O   1 
ATOM   2694 C  CB  . ASP A 1 329 ? 0.273   9.443  38.09  1 38.71   ? 347  ASP A CB  1 
ATOM   2695 C  CG  . ASP A 1 329 ? -0.147  8.85   36.749 1 45.676  ? 347  ASP A CG  1 
ATOM   2696 O  OD1 . ASP A 1 329 ? -0.869  9.541  35.996 1 47.592  ? 347  ASP A OD1 1 
ATOM   2697 O  OD2 . ASP A 1 329 ? 0.232   7.698  36.451 1 53.47   ? 347  ASP A OD2 1 
ATOM   2698 N  N   . ASP A 1 330 ? 0.371   12.473 40.155 1 35.764  ? 348  ASP A N   1 
ATOM   2699 C  CA  . ASP A 1 330 ? 0.192   12.905 41.542 1 36.359  ? 348  ASP A CA  1 
ATOM   2700 C  C   . ASP A 1 330 ? -0.989  13.874 41.616 1 38.53   ? 348  ASP A C   1 
ATOM   2701 O  O   . ASP A 1 330 ? -0.849  15.058 41.339 1 43.173  ? 348  ASP A O   1 
ATOM   2702 C  CB  . ASP A 1 330 ? 1.45    13.415 42.222 1 31.731  ? 348  ASP A CB  1 
ATOM   2703 C  CG  . ASP A 1 330 ? 1.291   13.72  43.71  1 40.257  ? 348  ASP A CG  1 
ATOM   2704 O  OD1 . ASP A 1 330 ? 0.151   13.57  44.258 1 48.725  ? 348  ASP A OD1 1 
ATOM   2705 O  OD2 . ASP A 1 330 ? 2.311   14.118 44.33  1 44.626  ? 348  ASP A OD2 1 
ATOM   2706 N  N   . VAL A 1 331 ? -2.151  13.309 41.975 1 37.506  ? 349  VAL A N   1 
ATOM   2707 C  CA  . VAL A 1 331 ? -3.399  14.017 42.158 1 33.29   ? 349  VAL A CA  1 
ATOM   2708 C  C   . VAL A 1 331 ? -4.011  13.567 43.48  1 35.373  ? 349  VAL A C   1 
ATOM   2709 O  O   . VAL A 1 331 ? -3.91   12.401 43.828 1 39.608  ? 349  VAL A O   1 
ATOM   2710 C  CB  . VAL A 1 331 ? -4.305  13.721 40.96  1 31.149  ? 349  VAL A CB  1 
ATOM   2711 C  CG1 . VAL A 1 331 ? -3.696  14.234 39.666 1 30.909  ? 349  VAL A CG1 1 
ATOM   2712 C  CG2 . VAL A 1 331 ? -4.606  12.236 40.837 1 35.104  ? 349  VAL A CG2 1 
ATOM   2713 N  N   . ARG A 1 332 ? -4.64   14.479 44.224 1 35.829  ? 350  ARG A N   1 
ATOM   2714 C  CA  . ARG A 1 332 ? -5.13   14.144 45.546 1 33.237  ? 350  ARG A CA  1 
ATOM   2715 C  C   . ARG A 1 332 ? -6.45   14.854 45.815 1 36.021  ? 350  ARG A C   1 
ATOM   2716 O  O   . ARG A 1 332 ? -6.699  15.893 45.208 1 31.723  ? 350  ARG A O   1 
ATOM   2717 C  CB  . ARG A 1 332 ? -4.174  14.611 46.634 1 33.613  ? 350  ARG A CB  1 
ATOM   2718 C  CG  . ARG A 1 332 ? -2.757  14.128 46.44  1 36.523  ? 350  ARG A CG  1 
ATOM   2719 C  CD  . ARG A 1 332 ? -1.893  14.611 47.582 1 36.213  ? 350  ARG A CD  1 
ATOM   2720 N  NE  . ARG A 1 332 ? -0.539  14.515 47.032 1 36.36   ? 350  ARG A NE  1 
ATOM   2721 C  CZ  . ARG A 1 332 ? 0.51    15.177 47.496 1 38.491  ? 350  ARG A CZ  1 
ATOM   2722 N  NH1 . ARG A 1 332 ? 0.513   15.734 48.694 1 32.805  ? 350  ARG A NH1 1 
ATOM   2723 N  NH2 . ARG A 1 332 ? 1.578   15.264 46.728 1 46.675  ? 350  ARG A NH2 1 
ATOM   2724 N  N   . ILE A 1 333 ? -7.243  14.28  46.751 1 29.244  ? 351  ILE A N   1 
ATOM   2725 C  CA  . ILE A 1 333 ? -8.432  14.905 47.286 1 26.204  ? 351  ILE A CA  1 
ATOM   2726 C  C   . ILE A 1 333 ? -8.279  15.033 48.79  1 29.372  ? 351  ILE A C   1 
ATOM   2727 O  O   . ILE A 1 333 ? -7.645  14.216 49.454 1 29.961  ? 351  ILE A O   1 
ATOM   2728 C  CB  . ILE A 1 333 ? -9.696  14.141 46.87  1 27.319  ? 351  ILE A CB  1 
ATOM   2729 C  CG1 . ILE A 1 333 ? -10.065 14.473 45.444 1 24.692  ? 351  ILE A CG1 1 
ATOM   2730 C  CG2 . ILE A 1 333 ? -10.873 14.405 47.804 1 28.338  ? 351  ILE A CG2 1 
ATOM   2731 C  CD1 . ILE A 1 333 ? -11.1   13.549 44.854 1 25.738  ? 351  ILE A CD1 1 
ATOM   2732 N  N   . LYS A 1 334 ? -8.797  16.15  49.29  1 29.964  ? 352  LYS A N   1 
ATOM   2733 C  CA  . LYS A 1 334 ? -8.907  16.387 50.712 1 31.028  ? 352  LYS A CA  1 
ATOM   2734 C  C   . LYS A 1 334 ? -10.389 16.615 50.993 1 33.393  ? 352  LYS A C   1 
ATOM   2735 O  O   . LYS A 1 334 ? -10.957 17.641 50.619 1 36.345  ? 352  LYS A O   1 
ATOM   2736 C  CB  . LYS A 1 334 ? -8.022  17.543 51.171 1 28.218  ? 352  LYS A CB  1 
ATOM   2737 C  CG  . LYS A 1 334 ? -8.136  17.797 52.639 1 29.341  ? 352  LYS A CG  1 
ATOM   2738 C  CD  . LYS A 1 334 ? -6.973  18.607 53.198 1 36.31   ? 352  LYS A CD  1 
ATOM   2739 C  CE  . LYS A 1 334 ? -6.702  19.942 52.583 1 38.625  ? 352  LYS A CE  1 
ATOM   2740 N  NZ  . LYS A 1 334 ? -7.761  20.89  52.936 1 44.339  ? 352  LYS A NZ  1 
ATOM   2741 N  N   . GLN A 1 335 ? -11.014 15.612 51.598 1 31.453  ? 353  GLN A N   1 
ATOM   2742 C  CA  . GLN A 1 335 ? -12.428 15.679 51.89  1 34.907  ? 353  GLN A CA  1 
ATOM   2743 C  C   . GLN A 1 335 ? -12.659 15.059 53.255 1 34.797  ? 353  GLN A C   1 
ATOM   2744 O  O   . GLN A 1 335 ? -12.213 13.951 53.496 1 35.045  ? 353  GLN A O   1 
ATOM   2745 C  CB  . GLN A 1 335 ? -13.24  14.975 50.807 1 35.628  ? 353  GLN A CB  1 
ATOM   2746 C  CG  . GLN A 1 335 ? -14.728 14.919 51.134 1 32.711  ? 353  GLN A CG  1 
ATOM   2747 C  CD  . GLN A 1 335 ? -15.588 14.455 49.985 1 33.24   ? 353  GLN A CD  1 
ATOM   2748 O  OE1 . GLN A 1 335 ? -15.162 14.387 48.821 1 32.134  ? 353  GLN A OE1 1 
ATOM   2749 N  NE2 . GLN A 1 335 ? -16.835 14.163 50.327 1 34.77   ? 353  GLN A NE2 1 
ATOM   2750 N  N   . CYS A 1 336 ? -13.353 15.78  54.135 1 35.573  ? 354  CYS A N   1 
ATOM   2751 C  CA  . CYS A 1 336 ? -13.733 15.222 55.419 1 36.216  ? 354  CYS A CA  1 
ATOM   2752 C  C   . CYS A 1 336 ? -15.012 14.415 55.234 1 36.929  ? 354  CYS A C   1 
ATOM   2753 O  O   . CYS A 1 336 ? -16.057 14.832 55.721 1 37.893  ? 354  CYS A O   1 
ATOM   2754 C  CB  . CYS A 1 336 ? -13.855 16.347 56.435 1 40.128  ? 354  CYS A CB  1 
ATOM   2755 S  SG  . CYS A 1 336 ? -12.271 17.201 56.675 1 41.107  ? 354  CYS A SG  1 
ATOM   2756 N  N   . THR A 1 337 ? -14.902 13.264 54.536 1 35.29   ? 355  THR A N   1 
ATOM   2757 C  CA  . THR A 1 337 ? -16.046 12.545 53.993 1 32.967  ? 355  THR A CA  1 
ATOM   2758 C  C   . THR A 1 337 ? -16.93  11.969 55.099 1 34.045  ? 355  THR A C   1 
ATOM   2759 O  O   . THR A 1 337 ? -16.438 11.46  56.1   1 36.388  ? 355  THR A O   1 
ATOM   2760 C  CB  . THR A 1 337 ? -15.59  11.419 53.077 1 32.916  ? 355  THR A CB  1 
ATOM   2761 O  OG1 . THR A 1 337 ? -14.612 11.849 52.134 1 32.677  ? 355  THR A OG1 1 
ATOM   2762 C  CG2 . THR A 1 337 ? -16.765 10.836 52.32  1 31.513  ? 355  THR A CG2 1 
ATOM   2763 N  N   . ARG A 1 338 ? -18.247 12.064 54.895 1 36.65   ? 356  ARG A N   1 
ATOM   2764 C  CA  . ARG A 1 338 ? -19.241 11.435 55.755 1 40.06   ? 356  ARG A CA  1 
ATOM   2765 C  C   . ARG A 1 338 ? -20.095 10.521 54.884 1 37.142  ? 356  ARG A C   1 
ATOM   2766 O  O   . ARG A 1 338 ? -20.156 10.689 53.666 1 36.816  ? 356  ARG A O   1 
ATOM   2767 C  CB  . ARG A 1 338 ? -20.132 12.439 56.498 1 39.912  ? 356  ARG A CB  1 
ATOM   2768 C  CG  . ARG A 1 338 ? -19.378 13.268 57.528 1 46.636  ? 356  ARG A CG  1 
ATOM   2769 C  CD  . ARG A 1 338 ? -20.143 14.488 58.064 1 53.135  ? 356  ARG A CD  1 
ATOM   2770 N  NE  . ARG A 1 338 ? -20.214 15.555 57.06  1 55.92   ? 356  ARG A NE  1 
ATOM   2771 C  CZ  . ARG A 1 338 ? -21.248 15.708 56.236 1 61.374  ? 356  ARG A CZ  1 
ATOM   2772 N  NH1 . ARG A 1 338 ? -22.386 15.091 56.489 1 65.411  ? 356  ARG A NH1 1 
ATOM   2773 N  NH2 . ARG A 1 338 ? -21.154 16.46  55.157 1 56.667  ? 356  ARG A NH2 1 
ATOM   2774 N  N   . VAL A 1 339 ? -20.727 9.534  55.514 1 35.606  ? 357  VAL A N   1 
ATOM   2775 C  CA  . VAL A 1 339 ? -21.505 8.564  54.763 1 38.478  ? 357  VAL A CA  1 
ATOM   2776 C  C   . VAL A 1 339 ? -22.937 9.077  54.607 1 39.491  ? 357  VAL A C   1 
ATOM   2777 O  O   . VAL A 1 339 ? -23.806 8.72   55.404 1 34.879  ? 357  VAL A O   1 
ATOM   2778 C  CB  . VAL A 1 339 ? -21.46  7.18   55.436 1 36.837  ? 357  VAL A CB  1 
ATOM   2779 C  CG1 . VAL A 1 339 ? -22.197 6.131  54.604 1 36.88   ? 357  VAL A CG1 1 
ATOM   2780 C  CG2 . VAL A 1 339 ? -20.027 6.743  55.682 1 37.526  ? 357  VAL A CG2 1 
ATOM   2781 N  N   . THR A 1 340 ? -23.15  9.936  53.599 1 40.222  ? 358  THR A N   1 
ATOM   2782 C  CA  . THR A 1 340 ? -24.482 10.423 53.27  1 41.14   ? 358  THR A CA  1 
ATOM   2783 C  C   . THR A 1 340 ? -24.6   10.476 51.756 1 40.17   ? 358  THR A C   1 
ATOM   2784 O  O   . THR A 1 340 ? -23.583 10.335 51.066 1 39.106  ? 358  THR A O   1 
ATOM   2785 C  CB  . THR A 1 340 ? -24.812 11.796 53.871 1 36.147  ? 358  THR A CB  1 
ATOM   2786 O  OG1 . THR A 1 340 ? -24.199 12.801 53.074 1 33.916  ? 358  THR A OG1 1 
ATOM   2787 C  CG2 . THR A 1 340 ? -24.444 11.929 55.336 1 34.701  ? 358  THR A CG2 1 
ATOM   2788 N  N   . GLN A 1 341 ? -25.845 10.699 51.305 1 36.278  ? 359  GLN A N   1 
ATOM   2789 C  CA  . GLN A 1 341 ? -26.209 10.786 49.898 1 40.595  ? 359  GLN A CA  1 
ATOM   2790 C  C   . GLN A 1 341 ? -25.528 12.008 49.297 1 41.235  ? 359  GLN A C   1 
ATOM   2791 O  O   . GLN A 1 341 ? -24.98  11.918 48.197 1 38.487  ? 359  GLN A O   1 
ATOM   2792 C  CB  . GLN A 1 341 ? -27.736 10.85  49.719 1 41.873  ? 359  GLN A CB  1 
ATOM   2793 C  CG  . GLN A 1 341 ? -28.227 11.29  48.336 1 45.264  ? 359  GLN A CG  1 
ATOM   2794 C  CD  . GLN A 1 341 ? -29.685 10.958 48.025 1 50.227  ? 359  GLN A CD  1 
ATOM   2795 O  OE1 . GLN A 1 341 ? -30.297 10.086 48.651 1 42.714  ? 359  GLN A OE1 1 
ATOM   2796 N  NE2 . GLN A 1 341 ? -30.256 11.597 47.006 1 49.112  ? 359  GLN A NE2 1 
ATOM   2797 N  N   . ASP A 1 342 ? -25.586 13.147 50.008 1 39.067  ? 360  ASP A N   1 
ATOM   2798 C  CA  . ASP A 1 342 ? -25.043 14.38  49.454 1 42.748  ? 360  ASP A CA  1 
ATOM   2799 C  C   . ASP A 1 342 ? -23.527 14.227 49.328 1 37.826  ? 360  ASP A C   1 
ATOM   2800 O  O   . ASP A 1 342 ? -22.971 14.643 48.32  1 33.255  ? 360  ASP A O   1 
ATOM   2801 C  CB  . ASP A 1 342 ? -25.507 15.65  50.17  1 48.512  ? 360  ASP A CB  1 
ATOM   2802 C  CG  . ASP A 1 342 ? -24.752 16.049 51.435 1 64.43   ? 360  ASP A CG  1 
ATOM   2803 O  OD1 . ASP A 1 342 ? -24.982 15.413 52.505 1 63.051  ? 360  ASP A OD1 1 
ATOM   2804 O  OD2 . ASP A 1 342 ? -23.915 16.99  51.338 1 80.764  ? 360  ASP A OD2 1 
ATOM   2805 N  N   . GLN A 1 343 ? -22.88  13.598 50.324 1 35.286  ? 361  GLN A N   1 
ATOM   2806 C  CA  . GLN A 1 343 ? -21.439 13.36  50.288 1 35.833  ? 361  GLN A CA  1 
ATOM   2807 C  C   . GLN A 1 343 ? -21.033 12.416 49.152 1 35.667  ? 361  GLN A C   1 
ATOM   2808 O  O   . GLN A 1 343 ? -19.964 12.586 48.578 1 37.735  ? 361  GLN A O   1 
ATOM   2809 C  CB  . GLN A 1 343 ? -20.943 12.799 51.61  1 33.46   ? 361  GLN A CB  1 
ATOM   2810 C  CG  . GLN A 1 343 ? -20.873 13.87  52.684 1 34.426  ? 361  GLN A CG  1 
ATOM   2811 C  CD  . GLN A 1 343 ? -19.628 14.708 52.546 1 36.767  ? 361  GLN A CD  1 
ATOM   2812 O  OE1 . GLN A 1 343 ? -18.515 14.235 52.784 1 35.267  ? 361  GLN A OE1 1 
ATOM   2813 N  NE2 . GLN A 1 343 ? -19.794 15.928 52.059 1 43.015  ? 361  GLN A NE2 1 
ATOM   2814 N  N   . LEU A 1 344 ? -21.892 11.463 48.799 1 31.466  ? 362  LEU A N   1 
ATOM   2815 C  CA  . LEU A 1 344 ? -21.638 10.625 47.647 1 35.421  ? 362  LEU A CA  1 
ATOM   2816 C  C   . LEU A 1 344 ? -21.553 11.485 46.388 1 33.889  ? 362  LEU A C   1 
ATOM   2817 O  O   . LEU A 1 344 ? -20.765 11.206 45.498 1 37.044  ? 362  LEU A O   1 
ATOM   2818 C  CB  . LEU A 1 344 ? -22.716 9.538  47.557 1 41.142  ? 362  LEU A CB  1 
ATOM   2819 C  CG  . LEU A 1 344 ? -22.621 8.528  46.402 1 41.872  ? 362  LEU A CG  1 
ATOM   2820 C  CD1 . LEU A 1 344 ? -21.396 7.635  46.515 1 45.349  ? 362  LEU A CD1 1 
ATOM   2821 C  CD2 . LEU A 1 344 ? -23.871 7.672  46.342 1 41.762  ? 362  LEU A CD2 1 
ATOM   2822 N  N   . PHE A 1 345 ? -22.364 12.535 46.294 1 40.231  ? 363  PHE A N   1 
ATOM   2823 C  CA  . PHE A 1 345 ? -22.353 13.387 45.11  1 38.488  ? 363  PHE A CA  1 
ATOM   2824 C  C   . PHE A 1 345 ? -21.078 14.214 45.095 1 33.671  ? 363  PHE A C   1 
ATOM   2825 O  O   . PHE A 1 345 ? -20.45  14.364 44.056 1 36.086  ? 363  PHE A O   1 
ATOM   2826 C  CB  . PHE A 1 345 ? -23.569 14.308 45.037 1 37.716  ? 363  PHE A CB  1 
ATOM   2827 C  CG  . PHE A 1 345 ? -24.902 13.567 44.968 1 42.802  ? 363  PHE A CG  1 
ATOM   2828 C  CD1 . PHE A 1 345 ? -24.992 12.281 44.443 1 44.814  ? 363  PHE A CD1 1 
ATOM   2829 C  CD2 . PHE A 1 345 ? -26.071 14.172 45.415 1 45.853  ? 363  PHE A CD2 1 
ATOM   2830 C  CE1 . PHE A 1 345 ? -26.212 11.628 44.364 1 48.217  ? 363  PHE A CE1 1 
ATOM   2831 C  CE2 . PHE A 1 345 ? -27.287 13.511 45.337 1 46.885  ? 363  PHE A CE2 1 
ATOM   2832 C  CZ  . PHE A 1 345 ? -27.357 12.24  44.816 1 46.565  ? 363  PHE A CZ  1 
ATOM   2833 N  N   . THR A 1 346 ? -20.694 14.71  46.267 1 29.019  ? 364  THR A N   1 
ATOM   2834 C  CA  . THR A 1 346 ? -19.484 15.489 46.418 1 32.046  ? 364  THR A CA  1 
ATOM   2835 C  C   . THR A 1 346 ? -18.269 14.669 45.981 1 35.327  ? 364  THR A C   1 
ATOM   2836 O  O   . THR A 1 346 ? -17.296 15.219 45.47  1 32.555  ? 364  THR A O   1 
ATOM   2837 C  CB  . THR A 1 346 ? -19.315 15.914 47.873 1 31.801  ? 364  THR A CB  1 
ATOM   2838 O  OG1 . THR A 1 346 ? -20.414 16.739 48.205 1 34.898  ? 364  THR A OG1 1 
ATOM   2839 C  CG2 . THR A 1 346 ? -18.05  16.719 48.107 1 32.423  ? 364  THR A CG2 1 
ATOM   2840 N  N   . VAL A 1 347 ? -18.273 13.378 46.319 1 35.386  ? 365  VAL A N   1 
ATOM   2841 C  CA  . VAL A 1 347 ? -17.148 12.518 46.005 1 34.258  ? 365  VAL A CA  1 
ATOM   2842 C  C   . VAL A 1 347 ? -17.013 12.472 44.491 1 32.6    ? 365  VAL A C   1 
ATOM   2843 O  O   . VAL A 1 347 ? -15.911 12.654 43.982 1 31.344  ? 365  VAL A O   1 
ATOM   2844 C  CB  . VAL A 1 347 ? -17.308 11.119 46.614 1 32.218  ? 365  VAL A CB  1 
ATOM   2845 C  CG1 . VAL A 1 347 ? -16.527 10.095 45.832 1 33.739  ? 365  VAL A CG1 1 
ATOM   2846 C  CG2 . VAL A 1 347 ? -16.935 11.117 48.09  1 32.173  ? 365  VAL A CG2 1 
ATOM   2847 N  N   . HIS A 1 348 ? -18.138 12.302 43.786 1 31.775  ? 366  HIS A N   1 
ATOM   2848 C  CA  . HIS A 1 348 ? -18.111 12.311 42.325 1 33.164  ? 366  HIS A CA  1 
ATOM   2849 C  C   . HIS A 1 348 ? -17.71  13.698 41.829 1 35.708  ? 366  HIS A C   1 
ATOM   2850 O  O   . HIS A 1 348 ? -16.998 13.801 40.836 1 38.12   ? 366  HIS A O   1 
ATOM   2851 C  CB  . HIS A 1 348 ? -19.428 11.818 41.711 1 31.913  ? 366  HIS A CB  1 
ATOM   2852 C  CG  . HIS A 1 348 ? -19.691 10.366 41.93  1 35.559  ? 366  HIS A CG  1 
ATOM   2853 N  ND1 . HIS A 1 348 ? -20.048 9.866  43.169 1 38.604  ? 366  HIS A ND1 1 
ATOM   2854 C  CD2 . HIS A 1 348 ? -19.643 9.301  41.092 1 35.031  ? 366  HIS A CD2 1 
ATOM   2855 C  CE1 . HIS A 1 348 ? -20.182 8.54   43.075 1 41.371  ? 366  HIS A CE1 1 
ATOM   2856 N  NE2 . HIS A 1 348 ? -19.941 8.177  41.823 1 38.349  ? 366  HIS A NE2 1 
ATOM   2857 N  N   . HIS A 1 349 ? -18.125 14.76  42.544 1 35.162  ? 367  HIS A N   1 
ATOM   2858 C  CA  . HIS A 1 349 ? -17.797 16.109 42.115 1 32.879  ? 367  HIS A CA  1 
ATOM   2859 C  C   . HIS A 1 349 ? -16.273 16.267 42.06  1 32.503  ? 367  HIS A C   1 
ATOM   2860 O  O   . HIS A 1 349 ? -15.728 16.729 41.048 1 33.273  ? 367  HIS A O   1 
ATOM   2861 C  CB  . HIS A 1 349 ? -18.471 17.184 42.985 1 29.748  ? 367  HIS A CB  1 
ATOM   2862 C  CG  . HIS A 1 349 ? -17.979 18.543 42.64  1 29.969  ? 367  HIS A CG  1 
ATOM   2863 N  ND1 . HIS A 1 349 ? -18.486 19.275 41.58  1 28.87   ? 367  HIS A ND1 1 
ATOM   2864 C  CD2 . HIS A 1 349 ? -16.94  19.237 43.13  1 31.266  ? 367  HIS A CD2 1 
ATOM   2865 C  CE1 . HIS A 1 349 ? -17.785 20.402 41.476 1 33.043  ? 367  HIS A CE1 1 
ATOM   2866 N  NE2 . HIS A 1 349 ? -16.843 20.404 42.401 1 32.447  ? 367  HIS A NE2 1 
ATOM   2867 N  N   . GLU A 1 350 ? -15.61  15.9   43.169 1 29.35   ? 368  GLU A N   1 
ATOM   2868 C  CA  . GLU A 1 350 ? -14.183 16.097 43.339 1 32.336  ? 368  GLU A CA  1 
ATOM   2869 C  C   . GLU A 1 350 ? -13.39  15.217 42.368 1 35.72   ? 368  GLU A C   1 
ATOM   2870 O  O   . GLU A 1 350 ? -12.33  15.634 41.894 1 32.668  ? 368  GLU A O   1 
ATOM   2871 C  CB  . GLU A 1 350 ? -13.716 15.833 44.77  1 36.429  ? 368  GLU A CB  1 
ATOM   2872 C  CG  . GLU A 1 350 ? -14.312 16.779 45.807 1 39.447  ? 368  GLU A CG  1 
ATOM   2873 C  CD  . GLU A 1 350 ? -14.181 18.275 45.512 1 44.283  ? 368  GLU A CD  1 
ATOM   2874 O  OE1 . GLU A 1 350 ? -13.377 18.741 44.676 1 42.135  ? 368  GLU A OE1 1 
ATOM   2875 O  OE2 . GLU A 1 350 ? -14.959 18.996 46.159 1 44.303  ? 368  GLU A OE2 1 
ATOM   2876 N  N   . LEU A 1 351 ? -13.903 14.009 42.094 1 34.059  ? 369  LEU A N   1 
ATOM   2877 C  CA  . LEU A 1 351 ? -13.238 13.051 41.228 1 33.546  ? 369  LEU A CA  1 
ATOM   2878 C  C   . LEU A 1 351 ? -13.327 13.514 39.78  1 31.673  ? 369  LEU A C   1 
ATOM   2879 O  O   . LEU A 1 351 ? -12.537 13.066 38.962 1 30.156  ? 369  LEU A O   1 
ATOM   2880 C  CB  . LEU A 1 351 ? -13.821 11.647 41.373 1 34.359  ? 369  LEU A CB  1 
ATOM   2881 C  CG  . LEU A 1 351 ? -13.472 10.895 42.661 1 38.98   ? 369  LEU A CG  1 
ATOM   2882 C  CD1 . LEU A 1 351 ? -14.225 9.558  42.63  1 42.021  ? 369  LEU A CD1 1 
ATOM   2883 C  CD2 . LEU A 1 351 ? -11.988 10.642 42.832 1 38.41   ? 369  LEU A CD2 1 
ATOM   2884 N  N   . GLY A 1 352 ? -14.296 14.381 39.464 1 28.872  ? 370  GLY A N   1 
ATOM   2885 C  CA  . GLY A 1 352 ? -14.36  14.994 38.143 1 29.031  ? 370  GLY A CA  1 
ATOM   2886 C  C   . GLY A 1 352 ? -13.153 15.907 37.916 1 31.313  ? 370  GLY A C   1 
ATOM   2887 O  O   . GLY A 1 352 ? -12.628 15.969 36.811 1 29.037  ? 370  GLY A O   1 
ATOM   2888 N  N   . HIS A 1 353 ? -12.709 16.595 38.981 1 28.478  ? 371  HIS A N   1 
ATOM   2889 C  CA  . HIS A 1 353 ? -11.528 17.431 38.881 1 32.226  ? 371  HIS A CA  1 
ATOM   2890 C  C   . HIS A 1 353 ? -10.311 16.554 38.625 1 33.124  ? 371  HIS A C   1 
ATOM   2891 O  O   . HIS A 1 353 ? -9.535  16.868 37.725 1 33.904  ? 371  HIS A O   1 
ATOM   2892 C  CB  . HIS A 1 353 ? -11.267 18.223 40.163 1 33.529  ? 371  HIS A CB  1 
ATOM   2893 C  CG  . HIS A 1 353 ? -12.262 19.308 40.383 1 36.167  ? 371  HIS A CG  1 
ATOM   2894 N  ND1 . HIS A 1 353 ? -12.609 20.208 39.399 1 35.406  ? 371  HIS A ND1 1 
ATOM   2895 C  CD2 . HIS A 1 353 ? -12.947 19.651 41.46  1 32.152  ? 371  HIS A CD2 1 
ATOM   2896 C  CE1 . HIS A 1 353 ? -13.478 21.058 39.892 1 34.816  ? 371  HIS A CE1 1 
ATOM   2897 N  NE2 . HIS A 1 353 ? -13.689 20.745 41.143 1 34.806  ? 371  HIS A NE2 1 
ATOM   2898 N  N   . ILE A 1 354 ? -10.176 15.478 39.424 1 29.407  ? 372  ILE A N   1 
ATOM   2899 C  CA  . ILE A 1 354 ? -9.08   14.532 39.29  1 29.597  ? 372  ILE A CA  1 
ATOM   2900 C  C   . ILE A 1 354 ? -9.047  14.008 37.845 1 28.691  ? 372  ILE A C   1 
ATOM   2901 O  O   . ILE A 1 354 ? -8.012  13.97  37.189 1 30.925  ? 372  ILE A O   1 
ATOM   2902 C  CB  . ILE A 1 354 ? -9.193  13.386 40.313 1 30.633  ? 372  ILE A CB  1 
ATOM   2903 C  CG1 . ILE A 1 354 ? -9.217  13.847 41.771 1 29.976  ? 372  ILE A CG1 1 
ATOM   2904 C  CG2 . ILE A 1 354 ? -8.083  12.366 40.099 1 29.716  ? 372  ILE A CG2 1 
ATOM   2905 C  CD1 . ILE A 1 354 ? -7.972  14.581 42.208 1 32.52   ? 372  ILE A CD1 1 
ATOM   2906 N  N   . GLN A 1 355 ? -10.186 13.603 37.319 1 27.68   ? 373  GLN A N   1 
ATOM   2907 C  CA  . GLN A 1 355 ? -10.187 13.044 35.984 1 29.446  ? 373  GLN A CA  1 
ATOM   2908 C  C   . GLN A 1 355 ? -9.621  14.082 35.02  1 31.608  ? 373  GLN A C   1 
ATOM   2909 O  O   . GLN A 1 355 ? -8.812  13.732 34.171 1 36.16   ? 373  GLN A O   1 
ATOM   2910 C  CB  . GLN A 1 355 ? -11.588 12.579 35.606 1 29.721  ? 373  GLN A CB  1 
ATOM   2911 C  CG  . GLN A 1 355 ? -11.685 11.909 34.238 1 32.2    ? 373  GLN A CG  1 
ATOM   2912 C  CD  . GLN A 1 355 ? -10.955 10.58  34.178 1 32.73   ? 373  GLN A CD  1 
ATOM   2913 O  OE1 . GLN A 1 355 ? -10.489 10.18  33.109 1 29.456  ? 373  GLN A OE1 1 
ATOM   2914 N  NE2 . GLN A 1 355 ? -10.803 9.91   35.318 1 27.526  ? 373  GLN A NE2 1 
ATOM   2915 N  N   . TYR A 1 356 ? -10.053 15.348 35.156 1 29.673  ? 374  TYR A N   1 
ATOM   2916 C  CA  . TYR A 1 356 ? -9.65   16.414 34.243 1 28.368  ? 374  TYR A CA  1 
ATOM   2917 C  C   . TYR A 1 356 ? -8.13   16.563 34.317 1 26.223  ? 374  TYR A C   1 
ATOM   2918 O  O   . TYR A 1 356 ? -7.481  16.67  33.294 1 24.476  ? 374  TYR A O   1 
ATOM   2919 C  CB  . TYR A 1 356 ? -10.33  17.747 34.604 1 30.366  ? 374  TYR A CB  1 
ATOM   2920 C  CG  . TYR A 1 356 ? -10.717 18.712 33.488 1 27.541  ? 374  TYR A CG  1 
ATOM   2921 C  CD1 . TYR A 1 356 ? -10.051 18.737 32.277 1 30.35   ? 374  TYR A CD1 1 
ATOM   2922 C  CD2 . TYR A 1 356 ? -11.764 19.6   33.657 1 28.195  ? 374  TYR A CD2 1 
ATOM   2923 C  CE1 . TYR A 1 356 ? -10.414 19.604 31.266 1 28.34   ? 374  TYR A CE1 1 
ATOM   2924 C  CE2 . TYR A 1 356 ? -12.127 20.496 32.668 1 27.272  ? 374  TYR A CE2 1 
ATOM   2925 C  CZ  . TYR A 1 356 ? -11.442 20.5   31.467 1 30.44   ? 374  TYR A CZ  1 
ATOM   2926 O  OH  . TYR A 1 356 ? -11.77  21.331 30.447 1 25.944  ? 374  TYR A OH  1 
ATOM   2927 N  N   . PHE A 1 357 ? -7.58   16.574 35.54  1 25.345  ? 375  PHE A N   1 
ATOM   2928 C  CA  . PHE A 1 357 ? -6.153  16.684 35.765 1 27.112  ? 375  PHE A CA  1 
ATOM   2929 C  C   . PHE A 1 357 ? -5.366  15.595 35.037 1 32.13   ? 375  PHE A C   1 
ATOM   2930 O  O   . PHE A 1 357 ? -4.265  15.871 34.542 1 30.866  ? 375  PHE A O   1 
ATOM   2931 C  CB  . PHE A 1 357 ? -5.786  16.499 37.229 1 26.022  ? 375  PHE A CB  1 
ATOM   2932 C  CG  . PHE A 1 357 ? -6.34   17.493 38.229 1 30.13   ? 375  PHE A CG  1 
ATOM   2933 C  CD1 . PHE A 1 357 ? -6.61   18.811 37.862 1 31.188  ? 375  PHE A CD1 1 
ATOM   2934 C  CD2 . PHE A 1 357 ? -6.508  17.122 39.565 1 31.116  ? 375  PHE A CD2 1 
ATOM   2935 C  CE1 . PHE A 1 357 ? -7.075  19.71  38.79  1 27.844  ? 375  PHE A CE1 1 
ATOM   2936 C  CE2 . PHE A 1 357 ? -6.966  18.035 40.507 1 30.675  ? 375  PHE A CE2 1 
ATOM   2937 C  CZ  . PHE A 1 357 ? -7.239  19.323 40.114 1 31.815  ? 375  PHE A CZ  1 
ATOM   2938 N  N   . LEU A 1 358 ? -5.889  14.353 35.066 1 31.861  ? 376  LEU A N   1 
ATOM   2939 C  CA  . LEU A 1 358 ? -5.23   13.219 34.426 1 33.947  ? 376  LEU A CA  1 
ATOM   2940 C  C   . LEU A 1 358 ? -5.385  13.311 32.908 1 33.23   ? 376  LEU A C   1 
ATOM   2941 O  O   . LEU A 1 358 ? -4.486  12.944 32.165 1 37.886  ? 376  LEU A O   1 
ATOM   2942 C  CB  . LEU A 1 358 ? -5.766  11.882 34.941 1 35.017  ? 376  LEU A CB  1 
ATOM   2943 C  CG  . LEU A 1 358 ? -5.578  11.619 36.436 1 35.032  ? 376  LEU A CG  1 
ATOM   2944 C  CD1 . LEU A 1 358 ? -6.465  10.48  36.849 1 36.535  ? 376  LEU A CD1 1 
ATOM   2945 C  CD2 . LEU A 1 358 ? -4.123  11.354 36.787 1 36.802  ? 376  LEU A CD2 1 
ATOM   2946 N  N   . GLN A 1 359 ? -6.525  13.796 32.441 1 29.412  ? 377  GLN A N   1 
ATOM   2947 C  CA  . GLN A 1 359 ? -6.794  13.847 31.024 1 30.192  ? 377  GLN A CA  1 
ATOM   2948 C  C   . GLN A 1 359 ? -5.883  14.854 30.337 1 31.663  ? 377  GLN A C   1 
ATOM   2949 O  O   . GLN A 1 359 ? -5.581  14.678 29.156 1 34.164  ? 377  GLN A O   1 
ATOM   2950 C  CB  . GLN A 1 359 ? -8.257  14.198 30.799 1 34.042  ? 377  GLN A CB  1 
ATOM   2951 C  CG  . GLN A 1 359 ? -9.215  13.048 31.074 1 36.1    ? 377  GLN A CG  1 
ATOM   2952 C  CD  . GLN A 1 359 ? -9.128  11.932 30.05  1 38.605  ? 377  GLN A CD  1 
ATOM   2953 O  OE1 . GLN A 1 359 ? -8.879  12.144 28.857 1 35.911  ? 377  GLN A OE1 1 
ATOM   2954 N  NE2 . GLN A 1 359 ? -9.353  10.711 30.513 1 42.377  ? 377  GLN A NE2 1 
ATOM   2955 N  N   . TYR A 1 360 ? -5.416  15.884 31.059 1 32.136  ? 378  TYR A N   1 
ATOM   2956 C  CA  . TYR A 1 360 ? -4.653  16.927 30.384 1 33.021  ? 378  TYR A CA  1 
ATOM   2957 C  C   . TYR A 1 360 ? -3.195  16.989 30.858 1 36.657  ? 378  TYR A C   1 
ATOM   2958 O  O   . TYR A 1 360 ? -2.498  17.941 30.508 1 34.228  ? 378  TYR A O   1 
ATOM   2959 C  CB  . TYR A 1 360 ? -5.363  18.288 30.46  1 26.642  ? 378  TYR A CB  1 
ATOM   2960 C  CG  . TYR A 1 360 ? -5.612  18.979 31.798 1 26.65   ? 378  TYR A CG  1 
ATOM   2961 C  CD1 . TYR A 1 360 ? -4.674  19.026 32.822 1 26.99   ? 378  TYR A CD1 1 
ATOM   2962 C  CD2 . TYR A 1 360 ? -6.826  19.624 32.015 1 29.826  ? 378  TYR A CD2 1 
ATOM   2963 C  CE1 . TYR A 1 360 ? -4.954  19.638 34.033 1 28.015  ? 378  TYR A CE1 1 
ATOM   2964 C  CE2 . TYR A 1 360 ? -7.12   20.231 33.223 1 26.077  ? 378  TYR A CE2 1 
ATOM   2965 C  CZ  . TYR A 1 360 ? -6.179  20.258 34.223 1 26.623  ? 378  TYR A CZ  1 
ATOM   2966 O  OH  . TYR A 1 360 ? -6.509  20.928 35.366 1 24.302  ? 378  TYR A OH  1 
ATOM   2967 N  N   . GLN A 1 361 ? -2.716  16.003 31.629 1 37.744  ? 379  GLN A N   1 
ATOM   2968 C  CA  . GLN A 1 361 ? -1.374  16.114 32.201 1 41.989  ? 379  GLN A CA  1 
ATOM   2969 C  C   . GLN A 1 361 ? -0.24   15.974 31.176 1 39.021  ? 379  GLN A C   1 
ATOM   2970 O  O   . GLN A 1 361 ? 0.898   16.296 31.49  1 43.336  ? 379  GLN A O   1 
ATOM   2971 C  CB  . GLN A 1 361 ? -1.099  15.153 33.349 1 42.384  ? 379  GLN A CB  1 
ATOM   2972 C  CG  . GLN A 1 361 ? -1.093  13.686 32.956 1 42.491  ? 379  GLN A CG  1 
ATOM   2973 C  CD  . GLN A 1 361 ? -0.925  12.818 34.181 1 45.328  ? 379  GLN A CD  1 
ATOM   2974 O  OE1 . GLN A 1 361 ? -0.888  13.298 35.329 1 42.147  ? 379  GLN A OE1 1 
ATOM   2975 N  NE2 . GLN A 1 361 ? -0.837  11.523 33.926 1 43.865  ? 379  GLN A NE2 1 
ATOM   2976 N  N   . HIS A 1 362 ? -0.544  15.494 29.973 1 34.508  ? 380  HIS A N   1 
ATOM   2977 C  CA  . HIS A 1 362 ? 0.408   15.503 28.881 1 38.78   ? 380  HIS A CA  1 
ATOM   2978 C  C   . HIS A 1 362 ? 0.525   16.875 28.213 1 40.314  ? 380  HIS A C   1 
ATOM   2979 O  O   . HIS A 1 362 ? 1.371   17.047 27.351 1 43.733  ? 380  HIS A O   1 
ATOM   2980 C  CB  . HIS A 1 362 ? -0.035  14.508 27.803 1 39.259  ? 380  HIS A CB  1 
ATOM   2981 C  CG  . HIS A 1 362 ? -1.283  14.891 27.088 1 38.719  ? 380  HIS A CG  1 
ATOM   2982 N  ND1 . HIS A 1 362 ? -2.509  14.863 27.719 1 36.053  ? 380  HIS A ND1 1 
ATOM   2983 C  CD2 . HIS A 1 362 ? -1.514  15.326 25.823 1 40.049  ? 380  HIS A CD2 1 
ATOM   2984 C  CE1 . HIS A 1 362 ? -3.451  15.252 26.848 1 37.929  ? 380  HIS A CE1 1 
ATOM   2985 N  NE2 . HIS A 1 362 ? -2.872  15.54  25.687 1 36.921  ? 380  HIS A NE2 1 
ATOM   2986 N  N   . GLN A 1 363 ? -0.357  17.829 28.54  1 38.543  ? 381  GLN A N   1 
ATOM   2987 C  CA  . GLN A 1 363 ? -0.333  19.147 27.926 1 35.224  ? 381  GLN A CA  1 
ATOM   2988 C  C   . GLN A 1 363 ? 0.791   19.978 28.524 1 31.794  ? 381  GLN A C   1 
ATOM   2989 O  O   . GLN A 1 363 ? 1.209   19.748 29.646 1 35.278  ? 381  GLN A O   1 
ATOM   2990 C  CB  . GLN A 1 363 ? -1.623  19.914 28.197 1 35.331  ? 381  GLN A CB  1 
ATOM   2991 C  CG  . GLN A 1 363 ? -2.836  19.333 27.483 1 33.505  ? 381  GLN A CG  1 
ATOM   2992 C  CD  . GLN A 1 363 ? -2.865  19.67  26.014 1 33.123  ? 381  GLN A CD  1 
ATOM   2993 O  OE1 . GLN A 1 363 ? -2.078  20.484 25.519 1 41.792  ? 381  GLN A OE1 1 
ATOM   2994 N  NE2 . GLN A 1 363 ? -3.842  19.128 25.311 1 32.854  ? 381  GLN A NE2 1 
ATOM   2995 N  N   . PRO A 1 364 ? 1.297   21.005 27.821 1 32.603  ? 382  PRO A N   1 
ATOM   2996 C  CA  . PRO A 1 364 ? 2.182   21.975 28.453 1 33.89   ? 382  PRO A CA  1 
ATOM   2997 C  C   . PRO A 1 364 ? 1.54    22.66  29.654 1 33.477  ? 382  PRO A C   1 
ATOM   2998 O  O   . PRO A 1 364 ? 0.335   22.85  29.69  1 31.957  ? 382  PRO A O   1 
ATOM   2999 C  CB  . PRO A 1 364 ? 2.485   22.989 27.354 1 35.112  ? 382  PRO A CB  1 
ATOM   3000 C  CG  . PRO A 1 364 ? 1.485   22.709 26.266 1 35.743  ? 382  PRO A CG  1 
ATOM   3001 C  CD  . PRO A 1 364 ? 1.041   21.285 26.407 1 34.166  ? 382  PRO A CD  1 
ATOM   3002 N  N   . PHE A 1 365 ? 2.365   23.047 30.628 1 35.021  ? 383  PHE A N   1 
ATOM   3003 C  CA  . PHE A 1 365 ? 1.883   23.548 31.898 1 35.269  ? 383  PHE A CA  1 
ATOM   3004 C  C   . PHE A 1 365 ? 0.769   24.596 31.747 1 38.128  ? 383  PHE A C   1 
ATOM   3005 O  O   . PHE A 1 365 ? -0.258  24.503 32.426 1 33.171  ? 383  PHE A O   1 
ATOM   3006 C  CB  . PHE A 1 365 ? 3.087   24.097 32.647 1 35.234  ? 383  PHE A CB  1 
ATOM   3007 C  CG  . PHE A 1 365 ? 2.656   24.864 33.882 1 37.806  ? 383  PHE A CG  1 
ATOM   3008 C  CD1 . PHE A 1 365 ? 2.39    24.194 35.071 1 38.045  ? 383  PHE A CD1 1 
ATOM   3009 C  CD2 . PHE A 1 365 ? 2.488   26.249 33.834 1 38.409  ? 383  PHE A CD2 1 
ATOM   3010 C  CE1 . PHE A 1 365 ? 1.994   24.902 36.199 1 41.168  ? 383  PHE A CE1 1 
ATOM   3011 C  CE2 . PHE A 1 365 ? 2.113   26.948 34.969 1 35.767  ? 383  PHE A CE2 1 
ATOM   3012 C  CZ  . PHE A 1 365 ? 1.858   26.274 36.141 1 36.836  ? 383  PHE A CZ  1 
ATOM   3013 N  N   . VAL A 1 366 ? 0.95    25.591 30.87  1 37.174  ? 384  VAL A N   1 
ATOM   3014 C  CA  . VAL A 1 366 ? -0.03   26.675 30.768 1 38.016  ? 384  VAL A CA  1 
ATOM   3015 C  C   . VAL A 1 366 ? -1.381  26.137 30.315 1 33.863  ? 384  VAL A C   1 
ATOM   3016 O  O   . VAL A 1 366 ? -2.382  26.77  30.589 1 31.899  ? 384  VAL A O   1 
ATOM   3017 C  CB  . VAL A 1 366 ? 0.355   27.86  29.863 1 38.79   ? 384  VAL A CB  1 
ATOM   3018 C  CG1 . VAL A 1 366 ? 1.395   28.757 30.529 1 44.781  ? 384  VAL A CG1 1 
ATOM   3019 C  CG2 . VAL A 1 366 ? 0.84    27.386 28.501 1 42.834  ? 384  VAL A CG2 1 
ATOM   3020 N  N   . TYR A 1 367 ? -1.415  24.994 29.618 1 34.28   ? 385  TYR A N   1 
ATOM   3021 C  CA  . TYR A 1 367 ? -2.677  24.4   29.178 1 31.738  ? 385  TYR A CA  1 
ATOM   3022 C  C   . TYR A 1 367 ? -3.288  23.387 30.153 1 28.865  ? 385  TYR A C   1 
ATOM   3023 O  O   . TYR A 1 367 ? -4.346  22.825 29.857 1 28.242  ? 385  TYR A O   1 
ATOM   3024 C  CB  . TYR A 1 367 ? -2.425  23.749 27.824 1 30.792  ? 385  TYR A CB  1 
ATOM   3025 C  CG  . TYR A 1 367 ? -2.221  24.735 26.683 1 34.685  ? 385  TYR A CG  1 
ATOM   3026 C  CD1 . TYR A 1 367 ? -2.575  26.085 26.784 1 33.79   ? 385  TYR A CD1 1 
ATOM   3027 C  CD2 . TYR A 1 367 ? -1.711  24.287 25.476 1 32.133  ? 385  TYR A CD2 1 
ATOM   3028 C  CE1 . TYR A 1 367 ? -2.404  26.945 25.716 1 32.16   ? 385  TYR A CE1 1 
ATOM   3029 C  CE2 . TYR A 1 367 ? -1.553  25.131 24.4   1 34.337  ? 385  TYR A CE2 1 
ATOM   3030 C  CZ  . TYR A 1 367 ? -1.886  26.468 24.52  1 36.756  ? 385  TYR A CZ  1 
ATOM   3031 O  OH  . TYR A 1 367 ? -1.703  27.252 23.41  1 35.195  ? 385  TYR A OH  1 
ATOM   3032 N  N   . ARG A 1 368 ? -2.68   23.199 31.331 1 30.453  ? 386  ARG A N   1 
ATOM   3033 C  CA  . ARG A 1 368 ? -3.115  22.194 32.288 1 31.933  ? 386  ARG A CA  1 
ATOM   3034 C  C   . ARG A 1 368 ? -4.077  22.857 33.26  1 30.052  ? 386  ARG A C   1 
ATOM   3035 O  O   . ARG A 1 368 ? -3.799  22.97  34.455 1 28.373  ? 386  ARG A O   1 
ATOM   3036 C  CB  . ARG A 1 368 ? -1.947  21.542 33.047 1 31.047  ? 386  ARG A CB  1 
ATOM   3037 C  CG  . ARG A 1 368 ? -1.069  20.734 32.1   1 35.135  ? 386  ARG A CG  1 
ATOM   3038 C  CD  . ARG A 1 368 ? 0.183   20.139 32.762 1 33.861  ? 386  ARG A CD  1 
ATOM   3039 N  NE  . ARG A 1 368 ? -0.121  19.018 33.648 1 35.285  ? 386  ARG A NE  1 
ATOM   3040 C  CZ  . ARG A 1 368 ? 0.756   18.359 34.407 1 38.742  ? 386  ARG A CZ  1 
ATOM   3041 N  NH1 . ARG A 1 368 ? 2.033   18.654 34.379 1 35.082  ? 386  ARG A NH1 1 
ATOM   3042 N  NH2 . ARG A 1 368 ? 0.353   17.407 35.23  1 41.915  ? 386  ARG A NH2 1 
ATOM   3043 N  N   . THR A 1 369 ? -5.222  23.258 32.716 1 30.103  ? 387  THR A N   1 
ATOM   3044 C  CA  . THR A 1 369 ? -6.333  23.754 33.505 1 29.79   ? 387  THR A CA  1 
ATOM   3045 C  C   . THR A 1 369 ? -7.55   23.585 32.629 1 26.301  ? 387  THR A C   1 
ATOM   3046 O  O   . THR A 1 369 ? -7.44   23.091 31.512 1 29.736  ? 387  THR A O   1 
ATOM   3047 C  CB  . THR A 1 369 ? -6.08   25.2   33.954 1 37.275  ? 387  THR A CB  1 
ATOM   3048 O  OG1 . THR A 1 369 ? -7.096  25.584 34.876 1 40.954  ? 387  THR A OG1 1 
ATOM   3049 C  CG2 . THR A 1 369 ? -6.095  26.191 32.809 1 37.647  ? 387  THR A CG2 1 
ATOM   3050 N  N   . GLY A 1 370 ? -8.703  24.015 33.122 1 29.349  ? 388  GLY A N   1 
ATOM   3051 C  CA  . GLY A 1 370 ? -9.959  23.799 32.418 1 27.158  ? 388  GLY A CA  1 
ATOM   3052 C  C   . GLY A 1 370 ? -10.097 24.715 31.214 1 27.33   ? 388  GLY A C   1 
ATOM   3053 O  O   . GLY A 1 370 ? -9.426  25.728 31.103 1 30.483  ? 388  GLY A O   1 
ATOM   3054 N  N   . ALA A 1 371 ? -10.961 24.328 30.286 1 29.823  ? 389  ALA A N   1 
ATOM   3055 C  CA  . ALA A 1 371 ? -11.214 25.17  29.137 1 32.619  ? 389  ALA A CA  1 
ATOM   3056 C  C   . ALA A 1 371 ? -11.748 26.517 29.622 1 34.158  ? 389  ALA A C   1 
ATOM   3057 O  O   . ALA A 1 371 ? -11.409 27.557 29.065 1 30.623  ? 389  ALA A O   1 
ATOM   3058 C  CB  . ALA A 1 371 ? -12.172 24.487 28.206 1 31.462  ? 389  ALA A CB  1 
ATOM   3059 N  N   . ASN A 1 372 ? -12.631 26.465 30.628 1 32.241  ? 390  ASN A N   1 
ATOM   3060 C  CA  . ASN A 1 372 ? -12.851 27.605 31.494 1 29.807  ? 390  ASN A CA  1 
ATOM   3061 C  C   . ASN A 1 372 ? -13.122 27.063 32.893 1 28.568  ? 390  ASN A C   1 
ATOM   3062 O  O   . ASN A 1 372 ? -13.297 25.865 33.077 1 27.263  ? 390  ASN A O   1 
ATOM   3063 C  CB  . ASN A 1 372 ? -13.869 28.595 30.921 1 29.241  ? 390  ASN A CB  1 
ATOM   3064 C  CG  . ASN A 1 372 ? -15.304 28.142 31.042 1 30.096  ? 390  ASN A CG  1 
ATOM   3065 O  OD1 . ASN A 1 372 ? -15.704 27.527 32.036 1 32.724  ? 390  ASN A OD1 1 
ATOM   3066 N  ND2 . ASN A 1 372 ? -16.101 28.438 30.034 1 30.859  ? 390  ASN A ND2 1 
ATOM   3067 N  N   . PRO A 1 373 ? -13.093 27.91  33.944 1 29.498  ? 391  PRO A N   1 
ATOM   3068 C  CA  . PRO A 1 373 ? -13.311 27.436 35.303 1 29.803  ? 391  PRO A CA  1 
ATOM   3069 C  C   . PRO A 1 373 ? -14.604 26.635 35.465 1 29.563  ? 391  PRO A C   1 
ATOM   3070 O  O   . PRO A 1 373 ? -14.663 25.719 36.27  1 28.504  ? 391  PRO A O   1 
ATOM   3071 C  CB  . PRO A 1 373 ? -13.325 28.722 36.109 1 31.286  ? 391  PRO A CB  1 
ATOM   3072 C  CG  . PRO A 1 373 ? -12.457 29.647 35.291 1 32.227  ? 391  PRO A CG  1 
ATOM   3073 C  CD  . PRO A 1 373 ? -12.808 29.348 33.88  1 30.034  ? 391  PRO A CD  1 
ATOM   3074 N  N   . GLY A 1 374 ? -15.637 27.007 34.702 1 27.326  ? 392  GLY A N   1 
ATOM   3075 C  CA  . GLY A 1 374 ? -16.922 26.348 34.784 1 28.344  ? 392  GLY A CA  1 
ATOM   3076 C  C   . GLY A 1 374 ? -16.83  24.909 34.305 1 29.517  ? 392  GLY A C   1 
ATOM   3077 O  O   . GLY A 1 374 ? -17.498 24.034 34.843 1 31.515  ? 392  GLY A O   1 
ATOM   3078 N  N   . PHE A 1 375 ? -16.019 24.674 33.274 1 30.336  ? 393  PHE A N   1 
ATOM   3079 C  CA  . PHE A 1 375 ? -15.862 23.329 32.733 1 31.073  ? 393  PHE A CA  1 
ATOM   3080 C  C   . PHE A 1 375 ? -15.304 22.395 33.798 1 29.408  ? 393  PHE A C   1 
ATOM   3081 O  O   . PHE A 1 375 ? -15.712 21.251 33.907 1 29.142  ? 393  PHE A O   1 
ATOM   3082 C  CB  . PHE A 1 375 ? -14.932 23.236 31.531 1 28.861  ? 393  PHE A CB  1 
ATOM   3083 C  CG  . PHE A 1 375 ? -15.591 23.6   30.212 1 29.069  ? 393  PHE A CG  1 
ATOM   3084 C  CD1 . PHE A 1 375 ? -16.339 24.762 30.091 1 31.664  ? 393  PHE A CD1 1 
ATOM   3085 C  CD2 . PHE A 1 375 ? -15.449 22.774 29.102 1 29.727  ? 393  PHE A CD2 1 
ATOM   3086 C  CE1 . PHE A 1 375 ? -16.934 25.091 28.886 1 34.426  ? 393  PHE A CE1 1 
ATOM   3087 C  CE2 . PHE A 1 375 ? -16.06  23.099 27.911 1 32.128  ? 393  PHE A CE2 1 
ATOM   3088 C  CZ  . PHE A 1 375 ? -16.787 24.269 27.801 1 34.146  ? 393  PHE A CZ  1 
ATOM   3089 N  N   . HIS A 1 376 ? -14.381 22.905 34.594 1 30.879  ? 394  HIS A N   1 
ATOM   3090 C  CA  . HIS A 1 376 ? -13.727 22.081 35.586 1 32.405  ? 394  HIS A CA  1 
ATOM   3091 C  C   . HIS A 1 376 ? -14.771 21.64  36.6   1 30.82   ? 394  HIS A C   1 
ATOM   3092 O  O   . HIS A 1 376 ? -14.76  20.497 37.016 1 32.224  ? 394  HIS A O   1 
ATOM   3093 C  CB  . HIS A 1 376 ? -12.548 22.829 36.226 1 31.722  ? 394  HIS A CB  1 
ATOM   3094 C  CG  . HIS A 1 376 ? -11.282 22.043 36.316 1 34.996  ? 394  HIS A CG  1 
ATOM   3095 N  ND1 . HIS A 1 376 ? -11.138 20.932 37.117 1 31.621  ? 394  HIS A ND1 1 
ATOM   3096 C  CD2 . HIS A 1 376 ? -10.106 22.183 35.657 1 34.227  ? 394  HIS A CD2 1 
ATOM   3097 C  CE1 . HIS A 1 376 ? -9.906  20.453 36.972 1 32.491  ? 394  HIS A CE1 1 
ATOM   3098 N  NE2 . HIS A 1 376 ? -9.258  21.201 36.107 1 32.455  ? 394  HIS A NE2 1 
ATOM   3099 N  N   . GLU A 1 377 ? -15.652 22.557 37.001 1 31.042  ? 395  GLU A N   1 
ATOM   3100 C  CA  . GLU A 1 377 ? -16.62  22.285 38.054 1 29.97   ? 395  GLU A CA  1 
ATOM   3101 C  C   . GLU A 1 377 ? -17.757 21.386 37.569 1 28.855  ? 395  GLU A C   1 
ATOM   3102 O  O   . GLU A 1 377 ? -18.445 20.763 38.375 1 29.609  ? 395  GLU A O   1 
ATOM   3103 C  CB  . GLU A 1 377 ? -17.148 23.621 38.581 1 31.923  ? 395  GLU A CB  1 
ATOM   3104 C  CG  . GLU A 1 377 ? -16.085 24.445 39.301 1 31.384  ? 395  GLU A CG  1 
ATOM   3105 C  CD  . GLU A 1 377 ? -15.485 23.76  40.524 1 33.977  ? 395  GLU A CD  1 
ATOM   3106 O  OE1 . GLU A 1 377 ? -16.029 22.747 41.042 1 35.653  ? 395  GLU A OE1 1 
ATOM   3107 O  OE2 . GLU A 1 377 ? -14.415 24.251 40.943 1 33.612  ? 395  GLU A OE2 1 
ATOM   3108 N  N   . ALA A 1 378 ? -17.994 21.342 36.255 1 28.925  ? 396  ALA A N   1 
ATOM   3109 C  CA  . ALA A 1 378 ? -19.121 20.598 35.711 1 29.686  ? 396  ALA A CA  1 
ATOM   3110 C  C   . ALA A 1 378 ? -18.84  19.094 35.619 1 32.269  ? 396  ALA A C   1 
ATOM   3111 O  O   . ALA A 1 378 ? -19.788 18.307 35.641 1 31.057  ? 396  ALA A O   1 
ATOM   3112 C  CB  . ALA A 1 378 ? -19.5   21.124 34.336 1 27.309  ? 396  ALA A CB  1 
ATOM   3113 N  N   . VAL A 1 379 ? -17.569 18.698 35.469 1 31.61   ? 397  VAL A N   1 
ATOM   3114 C  CA  . VAL A 1 379 ? -17.268 17.344 35.032 1 35.373  ? 397  VAL A CA  1 
ATOM   3115 C  C   . VAL A 1 379 ? -17.895 16.336 35.992 1 30.663  ? 397  VAL A C   1 
ATOM   3116 O  O   . VAL A 1 379 ? -18.617 15.466 35.567 1 30.994  ? 397  VAL A O   1 
ATOM   3117 C  CB  . VAL A 1 379 ? -15.763 17.056 34.91  1 41.051  ? 397  VAL A CB  1 
ATOM   3118 C  CG1 . VAL A 1 379 ? -15.51  15.594 34.549 1 42.27   ? 397  VAL A CG1 1 
ATOM   3119 C  CG2 . VAL A 1 379 ? -15.089 17.972 33.907 1 42.353  ? 397  VAL A CG2 1 
ATOM   3120 N  N   . GLY A 1 380 ? -17.605 16.457 37.289 1 33.179  ? 398  GLY A N   1 
ATOM   3121 C  CA  . GLY A 1 380 ? -18.059 15.506 38.282 1 31.732  ? 398  GLY A CA  1 
ATOM   3122 C  C   . GLY A 1 380 ? -19.575 15.564 38.433 1 34.796  ? 398  GLY A C   1 
ATOM   3123 O  O   . GLY A 1 380 ? -20.23  14.569 38.767 1 35.059  ? 398  GLY A O   1 
ATOM   3124 N  N   . ASP A 1 381 ? -20.122 16.752 38.188 1 33.066  ? 399  ASP A N   1 
ATOM   3125 C  CA  . ASP A 1 381 ? -21.55  16.949 38.356 1 35.662  ? 399  ASP A CA  1 
ATOM   3126 C  C   . ASP A 1 381 ? -22.316 16.161 37.289 1 36.048  ? 399  ASP A C   1 
ATOM   3127 O  O   . ASP A 1 381 ? -23.418 15.701 37.549 1 35.237  ? 399  ASP A O   1 
ATOM   3128 C  CB  . ASP A 1 381 ? -21.897 18.431 38.414 1 34.269  ? 399  ASP A CB  1 
ATOM   3129 C  CG  . ASP A 1 381 ? -21.621 19.112 39.746 1 37.974  ? 399  ASP A CG  1 
ATOM   3130 O  OD1 . ASP A 1 381 ? -20.958 18.46  40.603 1 39.027  ? 399  ASP A OD1 1 
ATOM   3131 O  OD2 . ASP A 1 381 ? -22.081 20.282 39.915 1 40.359  ? 399  ASP A OD2 1 
ATOM   3132 N  N   . VAL A 1 382 ? -21.739 15.994 36.094 1 37.156  ? 400  VAL A N   1 
ATOM   3133 C  CA  . VAL A 1 382 ? -22.428 15.234 35.066 1 39.171  ? 400  VAL A CA  1 
ATOM   3134 C  C   . VAL A 1 382 ? -22.626 13.816 35.593 1 39.145  ? 400  VAL A C   1 
ATOM   3135 O  O   . VAL A 1 382 ? -23.695 13.244 35.418 1 41.399  ? 400  VAL A O   1 
ATOM   3136 C  CB  . VAL A 1 382 ? -21.695 15.211 33.714 1 38.794  ? 400  VAL A CB  1 
ATOM   3137 C  CG1 . VAL A 1 382 ? -22.522 14.457 32.692 1 40.332  ? 400  VAL A CG1 1 
ATOM   3138 C  CG2 . VAL A 1 382 ? -21.389 16.616 33.198 1 37.853  ? 400  VAL A CG2 1 
ATOM   3139 N  N   . LEU A 1 383 ? -21.619 13.283 36.3   1 37.567  ? 401  LEU A N   1 
ATOM   3140 C  CA  . LEU A 1 383 ? -21.729 11.928 36.812 1 41.182  ? 401  LEU A CA  1 
ATOM   3141 C  C   . LEU A 1 383 ? -22.729 11.926 37.956 1 36.466  ? 401  LEU A C   1 
ATOM   3142 O  O   . LEU A 1 383 ? -23.506 10.992 38.052 1 40.202  ? 401  LEU A O   1 
ATOM   3143 C  CB  . LEU A 1 383 ? -20.429 11.249 37.254 1 45.13   ? 401  LEU A CB  1 
ATOM   3144 C  CG  . LEU A 1 383 ? -19.255 11.247 36.26  1 48.785  ? 401  LEU A CG  1 
ATOM   3145 C  CD1 . LEU A 1 383 ? -18.414 10.01  36.517 1 45.56   ? 401  LEU A CD1 1 
ATOM   3146 C  CD2 . LEU A 1 383 ? -19.612 11.341 34.788 1 47.878  ? 401  LEU A CD2 1 
ATOM   3147 N  N   . SER A 1 384 ? -22.691 12.955 38.813 1 39.153  ? 402  SER A N   1 
ATOM   3148 C  CA  . SER A 1 384 ? -23.564 13.031 39.977 1 38.009  ? 402  SER A CA  1 
ATOM   3149 C  C   . SER A 1 384 ? -25.032 13.03  39.554 1 33.89   ? 402  SER A C   1 
ATOM   3150 O  O   . SER A 1 384 ? -25.852 12.404 40.216 1 37.103  ? 402  SER A O   1 
ATOM   3151 C  CB  . SER A 1 384 ? -23.237 14.209 40.885 1 37.747  ? 402  SER A CB  1 
ATOM   3152 O  OG  . SER A 1 384 ? -22.139 13.915 41.755 1 37.494  ? 402  SER A OG  1 
ATOM   3153 N  N   . LEU A 1 385 ? -25.35  13.697 38.444 1 30.804  ? 403  LEU A N   1 
ATOM   3154 C  CA  . LEU A 1 385 ? -26.694 13.676 37.89  1 32.502  ? 403  LEU A CA  1 
ATOM   3155 C  C   . LEU A 1 385 ? -27.166 12.231 37.656 1 37.684  ? 403  LEU A C   1 
ATOM   3156 O  O   . LEU A 1 385 ? -28.306 11.918 37.998 1 39.174  ? 403  LEU A O   1 
ATOM   3157 C  CB  . LEU A 1 385 ? -26.785 14.538 36.625 1 31.502  ? 403  LEU A CB  1 
ATOM   3158 C  CG  . LEU A 1 385 ? -26.962 16.049 36.855 1 35.219  ? 403  LEU A CG  1 
ATOM   3159 C  CD1 . LEU A 1 385 ? -26.949 16.802 35.536 1 35.289  ? 403  LEU A CD1 1 
ATOM   3160 C  CD2 . LEU A 1 385 ? -28.271 16.386 37.596 1 36.793  ? 403  LEU A CD2 1 
ATOM   3161 N  N   . SER A 1 386 ? -26.3   11.364 37.092 1 38.716  ? 404  SER A N   1 
ATOM   3162 C  CA  . SER A 1 386 ? -26.582 9.946  36.888 1 34.655  ? 404  SER A CA  1 
ATOM   3163 C  C   . SER A 1 386 ? -26.681 9.209  38.211 1 30.321  ? 404  SER A C   1 
ATOM   3164 O  O   . SER A 1 386 ? -27.592 8.428  38.45  1 31.799  ? 404  SER A O   1 
ATOM   3165 C  CB  . SER A 1 386 ? -25.534 9.298  36.035 1 36.39   ? 404  SER A CB  1 
ATOM   3166 O  OG  . SER A 1 386 ? -25.884 9.409  34.666 1 44.069  ? 404  SER A OG  1 
ATOM   3167 N  N   . VAL A 1 387 ? -25.698 9.42   39.071 1 31.868  ? 405  VAL A N   1 
ATOM   3168 C  CA  . VAL A 1 387 ? -25.683 8.707  40.328 1 33.342  ? 405  VAL A CA  1 
ATOM   3169 C  C   . VAL A 1 387 ? -26.999 8.945  41.062 1 31.758  ? 405  VAL A C   1 
ATOM   3170 O  O   . VAL A 1 387 ? -27.535 8.031  41.653 1 37.211  ? 405  VAL A O   1 
ATOM   3171 C  CB  . VAL A 1 387 ? -24.488 9.1    41.198 1 35.535  ? 405  VAL A CB  1 
ATOM   3172 C  CG1 . VAL A 1 387 ? -24.632 8.512  42.591 1 39.919  ? 405  VAL A CG1 1 
ATOM   3173 C  CG2 . VAL A 1 387 ? -23.169 8.684  40.564 1 38.484  ? 405  VAL A CG2 1 
ATOM   3174 N  N   . SER A 1 388 ? -27.534 10.159 40.997 1 32.353  ? 406  SER A N   1 
ATOM   3175 C  CA  . SER A 1 388 ? -28.715 10.542 41.752 1 32.019  ? 406  SER A CA  1 
ATOM   3176 C  C   . SER A 1 388 ? -30.006 9.913  41.226 1 30.735  ? 406  SER A C   1 
ATOM   3177 O  O   . SER A 1 388 ? -31.029 9.991  41.924 1 34.047  ? 406  SER A O   1 
ATOM   3178 C  CB  . SER A 1 388 ? -28.875 12.049 41.715 1 31.428  ? 406  SER A CB  1 
ATOM   3179 O  OG  . SER A 1 388 ? -29.396 12.432 40.445 1 27.063  ? 406  SER A OG  1 
ATOM   3180 N  N   . THR A 1 389 ? -30     9.398  39.985 1 28.892  ? 407  THR A N   1 
ATOM   3181 C  CA  . THR A 1 389 ? -31.202 8.815  39.399 1 32.908  ? 407  THR A CA  1 
ATOM   3182 C  C   . THR A 1 389 ? -31.618 7.553  40.155 1 34.491  ? 407  THR A C   1 
ATOM   3183 O  O   . THR A 1 389 ? -30.772 6.779  40.6   1 35.445  ? 407  THR A O   1 
ATOM   3184 C  CB  . THR A 1 389 ? -31.055 8.465  37.923 1 35.626  ? 407  THR A CB  1 
ATOM   3185 O  OG1 . THR A 1 389 ? -30.168 7.349  37.88  1 35.841  ? 407  THR A OG1 1 
ATOM   3186 C  CG2 . THR A 1 389 ? -30.621 9.657  37.097 1 35.774  ? 407  THR A CG2 1 
ATOM   3187 N  N   . PRO A 1 390 ? -32.944 7.322  40.331 1 37.184  ? 408  PRO A N   1 
ATOM   3188 C  CA  . PRO A 1 390 ? -33.438 6.048  40.849 1 38.867  ? 408  PRO A CA  1 
ATOM   3189 C  C   . PRO A 1 390 ? -32.927 4.843  40.059 1 34.594  ? 408  PRO A C   1 
ATOM   3190 O  O   . PRO A 1 390 ? -32.572 3.833  40.644 1 36.886  ? 408  PRO A O   1 
ATOM   3191 C  CB  . PRO A 1 390 ? -34.973 6.178  40.797 1 40.677  ? 408  PRO A CB  1 
ATOM   3192 C  CG  . PRO A 1 390 ? -35.23  7.669  40.683 1 41.021  ? 408  PRO A CG  1 
ATOM   3193 C  CD  . PRO A 1 390 ? -34.016 8.295  40.052 1 38.25   ? 408  PRO A CD  1 
ATOM   3194 N  N   . LYS A 1 391 ? -32.828 4.992  38.733 1 33.047  ? 409  LYS A N   1 
ATOM   3195 C  CA  . LYS A 1 391 ? -32.218 3.982  37.881 1 34.521  ? 409  LYS A CA  1 
ATOM   3196 C  C   . LYS A 1 391 ? -30.868 3.537  38.44  1 37.756  ? 409  LYS A C   1 
ATOM   3197 O  O   . LYS A 1 391 ? -30.681 2.35   38.719 1 38.747  ? 409  LYS A O   1 
ATOM   3198 C  CB  . LYS A 1 391 ? -32.074 4.473  36.438 1 36.517  ? 409  LYS A CB  1 
ATOM   3199 C  CG  . LYS A 1 391 ? -31.531 3.446  35.454 1 41.129  ? 409  LYS A CG  1 
ATOM   3200 C  CD  . LYS A 1 391 ? -31.457 3.92   33.999 1 43.536  ? 409  LYS A CD  1 
ATOM   3201 C  CE  . LYS A 1 391 ? -32.796 4.011  33.307 1 43.423  ? 409  LYS A CE  1 
ATOM   3202 N  NZ  . LYS A 1 391 ? -32.76  4.715  32.014 1 46.641  ? 409  LYS A NZ  1 
ATOM   3203 N  N   . HIS A 1 392 ? -29.941 4.488  38.626 1 33.735  ? 410  HIS A N   1 
ATOM   3204 C  CA  . HIS A 1 392 ? -28.615 4.14   39.106 1 32.511  ? 410  HIS A CA  1 
ATOM   3205 C  C   . HIS A 1 392 ? -28.672 3.628  40.542 1 31.833  ? 410  HIS A C   1 
ATOM   3206 O  O   . HIS A 1 392 ? -27.913 2.713  40.902 1 32.004  ? 410  HIS A O   1 
ATOM   3207 C  CB  . HIS A 1 392 ? -27.602 5.294  38.978 1 33.951  ? 410  HIS A CB  1 
ATOM   3208 C  CG  . HIS A 1 392 ? -26.207 4.861  39.285 1 32.611  ? 410  HIS A CG  1 
ATOM   3209 N  ND1 . HIS A 1 392 ? -25.422 4.225  38.343 1 33.206  ? 410  HIS A ND1 1 
ATOM   3210 C  CD2 . HIS A 1 392 ? -25.495 4.855  40.445 1 35.029  ? 410  HIS A CD2 1 
ATOM   3211 C  CE1 . HIS A 1 392 ? -24.26  3.895  38.914 1 36.088  ? 410  HIS A CE1 1 
ATOM   3212 N  NE2 . HIS A 1 392 ? -24.272 4.271  40.187 1 34.514  ? 410  HIS A NE2 1 
ATOM   3213 N  N   . LEU A 1 393 ? -29.531 4.218  41.376 1 32.255  ? 411  LEU A N   1 
ATOM   3214 C  CA  . LEU A 1 393 ? -29.459 3.876  42.796 1 38.721  ? 411  LEU A CA  1 
ATOM   3215 C  C   . LEU A 1 393 ? -30.085 2.498  43.066 1 41.326  ? 411  LEU A C   1 
ATOM   3216 O  O   . LEU A 1 393 ? -29.783 1.888  44.091 1 35.595  ? 411  LEU A O   1 
ATOM   3217 C  CB  . LEU A 1 393 ? -30.038 4.955  43.712 1 35.967  ? 411  LEU A CB  1 
ATOM   3218 C  CG  . LEU A 1 393 ? -29.3   6.304  43.743 1 37.803  ? 411  LEU A CG  1 
ATOM   3219 C  CD1 . LEU A 1 393 ? -30.094 7.352  44.472 1 36.674  ? 411  LEU A CD1 1 
ATOM   3220 C  CD2 . LEU A 1 393 ? -27.925 6.229  44.379 1 35.336  ? 411  LEU A CD2 1 
ATOM   3221 N  N   . GLU A 1 394 ? -30.94  2.002  42.158 1 45.589  ? 412  GLU A N   1 
ATOM   3222 C  CA  . GLU A 1 394 ? -31.465 0.646  42.291 1 53.075  ? 412  GLU A CA  1 
ATOM   3223 C  C   . GLU A 1 394 ? -30.378 -0.36  41.891 1 44.291  ? 412  GLU A C   1 
ATOM   3224 O  O   . GLU A 1 394 ? -30.163 -1.317 42.615 1 38.522  ? 412  GLU A O   1 
ATOM   3225 C  CB  . GLU A 1 394 ? -32.717 0.335  41.464 1 57.15   ? 412  GLU A CB  1 
ATOM   3226 C  CG  . GLU A 1 394 ? -34.004 0.982  41.97  1 67.455  ? 412  GLU A CG  1 
ATOM   3227 C  CD  . GLU A 1 394 ? -35.212 0.763  41.051 1 75.585  ? 412  GLU A CD  1 
ATOM   3228 O  OE1 . GLU A 1 394 ? -35.579 1.651  40.229 1 77.357  ? 412  GLU A OE1 1 
ATOM   3229 O  OE2 . GLU A 1 394 ? -35.81  -0.321 41.181 1 64.181  ? 412  GLU A OE2 1 
ATOM   3230 N  N   . LYS A 1 395 ? -29.69  -0.101 40.766 1 38.814  ? 413  LYS A N   1 
ATOM   3231 C  CA  . LYS A 1 395 ? -28.548 -0.872 40.318 1 38.325  ? 413  LYS A CA  1 
ATOM   3232 C  C   . LYS A 1 395 ? -27.519 -1.104 41.43  1 36.845  ? 413  LYS A C   1 
ATOM   3233 O  O   . LYS A 1 395 ? -26.929 -2.171 41.464 1 38.298  ? 413  LYS A O   1 
ATOM   3234 C  CB  . LYS A 1 395 ? -27.692 -0.238 39.221 1 39.767  ? 413  LYS A CB  1 
ATOM   3235 C  CG  . LYS A 1 395 ? -28.227 -0.083 37.818 1 38.859  ? 413  LYS A CG  1 
ATOM   3236 C  CD  . LYS A 1 395 ? -27.014 0.14   36.919 1 42.471  ? 413  LYS A CD  1 
ATOM   3237 C  CE  . LYS A 1 395 ? -27.177 1.119  35.788 1 49.526  ? 413  LYS A CE  1 
ATOM   3238 N  NZ  . LYS A 1 395 ? -28.317 0.967  34.871 1 51.542  ? 413  LYS A NZ  1 
ATOM   3239 N  N   . ILE A 1 396 ? -27.239 -0.131 42.303 1 32.61   ? 414  ILE A N   1 
ATOM   3240 C  CA  . ILE A 1 396 ? -26.173 -0.321 43.282 1 35.644  ? 414  ILE A CA  1 
ATOM   3241 C  C   . ILE A 1 396 ? -26.748 -0.684 44.648 1 35.611  ? 414  ILE A C   1 
ATOM   3242 O  O   . ILE A 1 396 ? -26.001 -0.691 45.623 1 37.751  ? 414  ILE A O   1 
ATOM   3243 C  CB  . ILE A 1 396 ? -25.19  0.876  43.379 1 39.491  ? 414  ILE A CB  1 
ATOM   3244 C  CG1 . ILE A 1 396 ? -25.879 2.181  43.79  1 42.15   ? 414  ILE A CG1 1 
ATOM   3245 C  CG2 . ILE A 1 396 ? -24.395 1.055  42.084 1 38.982  ? 414  ILE A CG2 1 
ATOM   3246 C  CD1 . ILE A 1 396 ? -24.941 3.362  43.976 1 45.109  ? 414  ILE A CD1 1 
ATOM   3247 N  N   . GLY A 1 397 ? -28.063 -0.948 44.719 1 35.147  ? 415  GLY A N   1 
ATOM   3248 C  CA  . GLY A 1 397 ? -28.672 -1.55  45.891 1 31.634  ? 415  GLY A CA  1 
ATOM   3249 C  C   . GLY A 1 397 ? -28.918 -0.561 47.022 1 38.313  ? 415  GLY A C   1 
ATOM   3250 O  O   . GLY A 1 397 ? -29.072 -0.999 48.158 1 40.857  ? 415  GLY A O   1 
ATOM   3251 N  N   . LEU A 1 398 ? -28.965 0.755  46.724 1 39.523  ? 416  LEU A N   1 
ATOM   3252 C  CA  . LEU A 1 398 ? -29.174 1.764  47.751 1 38.572  ? 416  LEU A CA  1 
ATOM   3253 C  C   . LEU A 1 398 ? -30.645 2.172  47.827 1 41.245  ? 416  LEU A C   1 
ATOM   3254 O  O   . LEU A 1 398 ? -31.12  2.587  48.887 1 36.048  ? 416  LEU A O   1 
ATOM   3255 C  CB  . LEU A 1 398 ? -28.262 2.953  47.456 1 45.373  ? 416  LEU A CB  1 
ATOM   3256 C  CG  . LEU A 1 398 ? -26.766 2.733  47.721 1 45.339  ? 416  LEU A CG  1 
ATOM   3257 C  CD1 . LEU A 1 398 ? -25.982 4.024  47.504 1 41.631  ? 416  LEU A CD1 1 
ATOM   3258 C  CD2 . LEU A 1 398 ? -26.529 2.187  49.118 1 42.094  ? 416  LEU A CD2 1 
ATOM   3259 N  N   . LEU A 1 399 ? -31.362 2.006  46.707 1 38.386  ? 417  LEU A N   1 
ATOM   3260 C  CA  . LEU A 1 399 ? -32.766 2.346  46.615 1 38.903  ? 417  LEU A CA  1 
ATOM   3261 C  C   . LEU A 1 399 ? -33.602 1.078  46.478 1 44.925  ? 417  LEU A C   1 
ATOM   3262 O  O   . LEU A 1 399 ? -33.564 0.437  45.428 1 47.644  ? 417  LEU A O   1 
ATOM   3263 C  CB  . LEU A 1 399 ? -32.949 3.251  45.396 1 37.901  ? 417  LEU A CB  1 
ATOM   3264 C  CG  . LEU A 1 399 ? -34.342 3.862  45.215 1 39.69   ? 417  LEU A CG  1 
ATOM   3265 C  CD1 . LEU A 1 399 ? -34.787 4.527  46.517 1 45.137  ? 417  LEU A CD1 1 
ATOM   3266 C  CD2 . LEU A 1 399 ? -34.41  4.861  44.063 1 39.614  ? 417  LEU A CD2 1 
ATOM   3267 N  N   . LYS A 1 400 ? -34.408 0.759  47.506 1 48.525  ? 418  LYS A N   1 
ATOM   3268 C  CA  . LYS A 1 400 ? -35.204 -0.465 47.487 1 55.821  ? 418  LYS A CA  1 
ATOM   3269 C  C   . LYS A 1 400 ? -36.702 -0.17  47.397 1 53.409  ? 418  LYS A C   1 
ATOM   3270 O  O   . LYS A 1 400 ? -37.19  0.831  47.942 1 49.406  ? 418  LYS A O   1 
ATOM   3271 C  CB  . LYS A 1 400 ? -34.946 -1.275 48.758 1 62.546  ? 418  LYS A CB  1 
ATOM   3272 C  CG  . LYS A 1 400 ? -33.539 -1.842 48.897 1 67.542  ? 418  LYS A CG  1 
ATOM   3273 C  CD  . LYS A 1 400 ? -33.151 -2.018 50.364 1 78.152  ? 418  LYS A CD  1 
ATOM   3274 C  CE  . LYS A 1 400 ? -32.111 -3.065 50.619 1 82.62   ? 418  LYS A CE  1 
ATOM   3275 N  NZ  . LYS A 1 400 ? -31.046 -3.039 49.612 1 84.244  ? 418  LYS A NZ  1 
ATOM   3276 N  N   . ASP A 1 401 ? -37.408 -1.066 46.686 1 53.132  ? 419  ASP A N   1 
ATOM   3277 C  CA  . ASP A 1 401 ? -38.872 -1.133 46.63  1 58.089  ? 419  ASP A CA  1 
ATOM   3278 C  C   . ASP A 1 401 ? -39.488 0.141  46.041 1 54.498  ? 419  ASP A C   1 
ATOM   3279 O  O   . ASP A 1 401 ? -40.543 0.582  46.486 1 49.373  ? 419  ASP A O   1 
ATOM   3280 C  CB  . ASP A 1 401 ? -39.477 -1.468 47.989 1 62.957  ? 419  ASP A CB  1 
ATOM   3281 C  CG  . ASP A 1 401 ? -39.054 -2.811 48.578 1 68.332  ? 419  ASP A CG  1 
ATOM   3282 O  OD1 . ASP A 1 401 ? -38.941 -3.797 47.802 1 61.078  ? 419  ASP A OD1 1 
ATOM   3283 O  OD2 . ASP A 1 401 ? -38.867 -2.871 49.809 1 70.363  ? 419  ASP A OD2 1 
ATOM   3284 N  N   . TYR A 1 402 ? -38.834 0.687  45.009 1 49.684  ? 420  TYR A N   1 
ATOM   3285 C  CA  . TYR A 1 402 ? -39.141 1.987  44.451 1 45.473  ? 420  TYR A CA  1 
ATOM   3286 C  C   . TYR A 1 402 ? -40.012 1.754  43.233 1 48.067  ? 420  TYR A C   1 
ATOM   3287 O  O   . TYR A 1 402 ? -39.577 1.052  42.34  1 48.945  ? 420  TYR A O   1 
ATOM   3288 C  CB  . TYR A 1 402 ? -37.857 2.712  44.015 1 42.985  ? 420  TYR A CB  1 
ATOM   3289 C  CG  . TYR A 1 402 ? -38.033 4.141  43.518 1 39.292  ? 420  TYR A CG  1 
ATOM   3290 C  CD1 . TYR A 1 402 ? -38.118 5.198  44.42  1 36.299  ? 420  TYR A CD1 1 
ATOM   3291 C  CD2 . TYR A 1 402 ? -38.095 4.441  42.161 1 36.282  ? 420  TYR A CD2 1 
ATOM   3292 C  CE1 . TYR A 1 402 ? -38.288 6.504  43.991 1 36.309  ? 420  TYR A CE1 1 
ATOM   3293 C  CE2 . TYR A 1 402 ? -38.267 5.747  41.72  1 36.989  ? 420  TYR A CE2 1 
ATOM   3294 C  CZ  . TYR A 1 402 ? -38.349 6.785  42.638 1 36.761  ? 420  TYR A CZ  1 
ATOM   3295 O  OH  . TYR A 1 402 ? -38.495 8.094  42.263 1 32.929  ? 420  TYR A OH  1 
ATOM   3296 N  N   . VAL A 1 403 ? -41.213 2.344  43.225 1 50.281  ? 421  VAL A N   1 
ATOM   3297 C  CA  . VAL A 1 403 ? -42.073 2.414  42.054 1 50.044  ? 421  VAL A CA  1 
ATOM   3298 C  C   . VAL A 1 403 ? -41.954 3.811  41.458 1 48.869  ? 421  VAL A C   1 
ATOM   3299 O  O   . VAL A 1 403 ? -42.302 4.8    42.105 1 43.486  ? 421  VAL A O   1 
ATOM   3300 C  CB  . VAL A 1 403 ? -43.551 2.132  42.407 1 50.005  ? 421  VAL A CB  1 
ATOM   3301 C  CG1 . VAL A 1 403 ? -44.461 2.349  41.201 1 43.182  ? 421  VAL A CG1 1 
ATOM   3302 C  CG2 . VAL A 1 403 ? -43.751 0.742  43.015 1 52.111  ? 421  VAL A CG2 1 
ATOM   3303 N  N   . ARG A 1 404 ? -41.553 3.881  40.191 1 53.165  ? 422  ARG A N   1 
ATOM   3304 C  CA  . ARG A 1 404 ? -41.433 5.165  39.523 1 55.029  ? 422  ARG A CA  1 
ATOM   3305 C  C   . ARG A 1 404 ? -42.735 5.523  38.806 1 48.871  ? 422  ARG A C   1 
ATOM   3306 O  O   . ARG A 1 404 ? -42.784 5.526  37.575 1 52.984  ? 422  ARG A O   1 
ATOM   3307 C  CB  . ARG A 1 404 ? -40.235 5.142  38.571 1 58.433  ? 422  ARG A CB  1 
ATOM   3308 C  CG  . ARG A 1 404 ? -39.977 6.5    37.932 1 64.07   ? 422  ARG A CG  1 
ATOM   3309 C  CD  . ARG A 1 404 ? -38.601 6.533  37.318 1 63.081  ? 422  ARG A CD  1 
ATOM   3310 N  NE  . ARG A 1 404 ? -38.256 7.88   36.858 1 63.447  ? 422  ARG A NE  1 
ATOM   3311 C  CZ  . ARG A 1 404 ? -38.631 8.424  35.716 1 55.772  ? 422  ARG A CZ  1 
ATOM   3312 N  NH1 . ARG A 1 404 ? -39.374 7.738  34.869 1 58.918  ? 422  ARG A NH1 1 
ATOM   3313 N  NH2 . ARG A 1 404 ? -38.247 9.652  35.425 1 48.874  ? 422  ARG A NH2 1 
ATOM   3314 N  N   . ASP A 1 405 ? -43.771 5.866  39.58  1 46.071  ? 423  ASP A N   1 
ATOM   3315 C  CA  . ASP A 1 405 ? -44.992 6.448  39.023 1 51.217  ? 423  ASP A CA  1 
ATOM   3316 C  C   . ASP A 1 405 ? -44.791 7.946  38.766 1 48.289  ? 423  ASP A C   1 
ATOM   3317 O  O   . ASP A 1 405 ? -43.727 8.511  39.027 1 51.263  ? 423  ASP A O   1 
ATOM   3318 C  CB  . ASP A 1 405 ? -46.206 6.145  39.894 1 54.684  ? 423  ASP A CB  1 
ATOM   3319 C  CG  . ASP A 1 405 ? -46.09  6.632  41.331 1 62.152  ? 423  ASP A CG  1 
ATOM   3320 O  OD1 . ASP A 1 405 ? -45.753 7.814  41.495 1 58.146  ? 423  ASP A OD1 1 
ATOM   3321 O  OD2 . ASP A 1 405 ? -46.308 5.826  42.27  1 62.596  ? 423  ASP A OD2 1 
ATOM   3322 N  N   . ASP A 1 406 ? -45.838 8.591  38.248 1 48.951  ? 424  ASP A N   1 
ATOM   3323 C  CA  . ASP A 1 406 ? -45.794 9.999  37.89  1 50.279  ? 424  ASP A CA  1 
ATOM   3324 C  C   . ASP A 1 406 ? -45.527 10.888 39.109 1 47.561  ? 424  ASP A C   1 
ATOM   3325 O  O   . ASP A 1 406 ? -44.91  11.944 38.977 1 44.657  ? 424  ASP A O   1 
ATOM   3326 C  CB  . ASP A 1 406 ? -47.072 10.421 37.185 1 55.554  ? 424  ASP A CB  1 
ATOM   3327 C  CG  . ASP A 1 406 ? -47.206 9.968  35.737 1 69.66   ? 424  ASP A CG  1 
ATOM   3328 O  OD1 . ASP A 1 406 ? -46.172 9.625  35.128 1 79.673  ? 424  ASP A OD1 1 
ATOM   3329 O  OD2 . ASP A 1 406 ? -48.346 9.962  35.223 1 83.915  ? 424  ASP A OD2 1 
ATOM   3330 N  N   . GLU A 1 407 ? -45.989 10.468 40.289 1 42.144  ? 425  GLU A N   1 
ATOM   3331 C  CA  . GLU A 1 407 ? -45.854 11.269 41.495 1 42.251  ? 425  GLU A CA  1 
ATOM   3332 C  C   . GLU A 1 407 ? -44.442 11.143 42.066 1 38.439  ? 425  GLU A C   1 
ATOM   3333 O  O   . GLU A 1 407 ? -43.907 12.099 42.601 1 41.839  ? 425  GLU A O   1 
ATOM   3334 C  CB  . GLU A 1 407 ? -46.955 10.91  42.5   1 47.687  ? 425  GLU A CB  1 
ATOM   3335 C  CG  . GLU A 1 407 ? -48.347 11.356 42.039 1 53.72   ? 425  GLU A CG  1 
ATOM   3336 C  CD  . GLU A 1 407 ? -49.53  11.051 42.958 1 60.645  ? 425  GLU A CD  1 
ATOM   3337 O  OE1 . GLU A 1 407 ? -49.354 10.341 43.975 1 55.803  ? 425  GLU A OE1 1 
ATOM   3338 O  OE2 . GLU A 1 407 ? -50.643 11.567 42.674 1 65.911  ? 425  GLU A OE2 1 
ATOM   3339 N  N   . ALA A 1 408 ? -43.831 9.962  41.969 1 39.217  ? 426  ALA A N   1 
ATOM   3340 C  CA  . ALA A 1 408 ? -42.479 9.787  42.452 1 39.082  ? 426  ALA A CA  1 
ATOM   3341 C  C   . ALA A 1 408 ? -41.514 10.521 41.527 1 39.871  ? 426  ALA A C   1 
ATOM   3342 O  O   . ALA A 1 408 ? -40.442 10.919 41.964 1 37.666  ? 426  ALA A O   1 
ATOM   3343 C  CB  . ALA A 1 408 ? -42.118 8.334  42.531 1 36.988  ? 426  ALA A CB  1 
ATOM   3344 N  N   . ARG A 1 409 ? -41.886 10.653 40.249 1 34.528  ? 427  ARG A N   1 
ATOM   3345 C  CA  . ARG A 1 409 ? -41.059 11.377 39.309 1 36.095  ? 427  ARG A CA  1 
ATOM   3346 C  C   . ARG A 1 409 ? -41.03  12.869 39.67  1 36.813  ? 427  ARG A C   1 
ATOM   3347 O  O   . ARG A 1 409 ? -39.982 13.506 39.624 1 34.088  ? 427  ARG A O   1 
ATOM   3348 C  CB  . ARG A 1 409 ? -41.623 11.165 37.906 1 37.195  ? 427  ARG A CB  1 
ATOM   3349 C  CG  . ARG A 1 409 ? -40.652 11.719 36.882 1 40.149  ? 427  ARG A CG  1 
ATOM   3350 C  CD  . ARG A 1 409 ? -41.334 12     35.561 1 41.698  ? 427  ARG A CD  1 
ATOM   3351 N  NE  . ARG A 1 409 ? -40.337 12.461 34.593 1 40.817  ? 427  ARG A NE  1 
ATOM   3352 C  CZ  . ARG A 1 409 ? -40.632 12.755 33.343 1 42.973  ? 427  ARG A CZ  1 
ATOM   3353 N  NH1 . ARG A 1 409 ? -41.886 12.699 32.946 1 47.661  ? 427  ARG A NH1 1 
ATOM   3354 N  NH2 . ARG A 1 409 ? -39.699 13.118 32.487 1 40.729  ? 427  ARG A NH2 1 
ATOM   3355 N  N   . ILE A 1 410 ? -42.196 13.439 39.994 1 37.866  ? 428  ILE A N   1 
ATOM   3356 C  CA  . ILE A 1 410 ? -42.297 14.829 40.387 1 36.36   ? 428  ILE A CA  1 
ATOM   3357 C  C   . ILE A 1 410 ? -41.481 15.026 41.662 1 34.53   ? 428  ILE A C   1 
ATOM   3358 O  O   . ILE A 1 410 ? -40.794 16.043 41.785 1 31.333  ? 428  ILE A O   1 
ATOM   3359 C  CB  . ILE A 1 410 ? -43.767 15.271 40.55  1 41.325  ? 428  ILE A CB  1 
ATOM   3360 C  CG1 . ILE A 1 410 ? -44.511 15.291 39.222 1 42.939  ? 428  ILE A CG1 1 
ATOM   3361 C  CG2 . ILE A 1 410 ? -43.882 16.631 41.24  1 39.931  ? 428  ILE A CG2 1 
ATOM   3362 C  CD1 . ILE A 1 410 ? -43.84  16.117 38.149 1 46.496  ? 428  ILE A CD1 1 
ATOM   3363 N  N   . ASN A 1 411 ? -41.559 14.073 42.606 1 30.892  ? 429  ASN A N   1 
ATOM   3364 C  CA  . ASN A 1 411 ? -40.784 14.183 43.837 1 32.686  ? 429  ASN A CA  1 
ATOM   3365 C  C   . ASN A 1 411 ? -39.278 14.283 43.554 1 33.454  ? 429  ASN A C   1 
ATOM   3366 O  O   . ASN A 1 411 ? -38.575 15.052 44.202 1 34.133  ? 429  ASN A O   1 
ATOM   3367 C  CB  . ASN A 1 411 ? -40.997 13.01  44.784 1 34.185  ? 429  ASN A CB  1 
ATOM   3368 C  CG  . ASN A 1 411 ? -42.19  13.187 45.687 1 37.738  ? 429  ASN A CG  1 
ATOM   3369 O  OD1 . ASN A 1 411 ? -42.838 14.237 45.679 1 40.533  ? 429  ASN A OD1 1 
ATOM   3370 N  ND2 . ASN A 1 411 ? -42.486 12.176 46.485 1 37.07   ? 429  ASN A ND2 1 
ATOM   3371 N  N   . GLN A 1 412 ? -38.789 13.465 42.618 1 32.704  ? 430  GLN A N   1 
ATOM   3372 C  CA  . GLN A 1 412 ? -37.372 13.372 42.315 1 35.529  ? 430  GLN A CA  1 
ATOM   3373 C  C   . GLN A 1 412 ? -36.944 14.609 41.52  1 33.721  ? 430  GLN A C   1 
ATOM   3374 O  O   . GLN A 1 412 ? -35.882 15.166 41.767 1 34.43   ? 430  GLN A O   1 
ATOM   3375 C  CB  . GLN A 1 412 ? -37.108 12.059 41.568 1 38.076  ? 430  GLN A CB  1 
ATOM   3376 C  CG  . GLN A 1 412 ? -35.712 11.94  40.957 1 35.981  ? 430  GLN A CG  1 
ATOM   3377 C  CD  . GLN A 1 412 ? -34.634 11.869 42.017 1 38.042  ? 430  GLN A CD  1 
ATOM   3378 O  OE1 . GLN A 1 412 ? -34.878 11.554 43.192 1 36.291  ? 430  GLN A OE1 1 
ATOM   3379 N  NE2 . GLN A 1 412 ? -33.409 12.148 41.599 1 41.046  ? 430  GLN A NE2 1 
ATOM   3380 N  N   . LEU A 1 413 ? -37.758 15.014 40.538 1 33.097  ? 431  LEU A N   1 
ATOM   3381 C  CA  . LEU A 1 413 ? -37.525 16.242 39.813 1 33.791  ? 431  LEU A CA  1 
ATOM   3382 C  C   . LEU A 1 413 ? -37.435 17.422 40.794 1 35.257  ? 431  LEU A C   1 
ATOM   3383 O  O   . LEU A 1 413 ? -36.521 18.235 40.731 1 36.091  ? 431  LEU A O   1 
ATOM   3384 C  CB  . LEU A 1 413 ? -38.617 16.418 38.766 1 36.087  ? 431  LEU A CB  1 
ATOM   3385 C  CG  . LEU A 1 413 ? -38.354 15.772 37.401 1 40.476  ? 431  LEU A CG  1 
ATOM   3386 C  CD1 . LEU A 1 413 ? -39.593 15.819 36.514 1 39.85   ? 431  LEU A CD1 1 
ATOM   3387 C  CD2 . LEU A 1 413 ? -37.198 16.435 36.64  1 40.125  ? 431  LEU A CD2 1 
ATOM   3388 N  N   . PHE A 1 414 ? -38.349 17.496 41.752 1 33.384  ? 432  PHE A N   1 
ATOM   3389 C  CA  . PHE A 1 414 ? -38.346 18.6   42.692 1 30.233  ? 432  PHE A CA  1 
ATOM   3390 C  C   . PHE A 1 414 ? -37.091 18.582 43.56  1 28.648  ? 432  PHE A C   1 
ATOM   3391 O  O   . PHE A 1 414 ? -36.501 19.625 43.789 1 30.167  ? 432  PHE A O   1 
ATOM   3392 C  CB  . PHE A 1 414 ? -39.605 18.514 43.544 1 28.848  ? 432  PHE A CB  1 
ATOM   3393 C  CG  . PHE A 1 414 ? -39.9   19.784 44.301 1 29.506  ? 432  PHE A CG  1 
ATOM   3394 C  CD1 . PHE A 1 414 ? -40.426 20.883 43.642 1 32.66   ? 432  PHE A CD1 1 
ATOM   3395 C  CD2 . PHE A 1 414 ? -39.672 19.865 45.665 1 31.185  ? 432  PHE A CD2 1 
ATOM   3396 C  CE1 . PHE A 1 414 ? -40.708 22.046 44.34  1 34.152  ? 432  PHE A CE1 1 
ATOM   3397 C  CE2 . PHE A 1 414 ? -39.971 21.025 46.355 1 32.21   ? 432  PHE A CE2 1 
ATOM   3398 C  CZ  . PHE A 1 414 ? -40.49  22.112 45.693 1 32.755  ? 432  PHE A CZ  1 
ATOM   3399 N  N   . LEU A 1 415 ? -36.72  17.401 44.061 1 29.227  ? 433  LEU A N   1 
ATOM   3400 C  CA  . LEU A 1 415 ? -35.529 17.208 44.869 1 31.684  ? 433  LEU A CA  1 
ATOM   3401 C  C   . LEU A 1 415 ? -34.298 17.716 44.124 1 31.589  ? 433  LEU A C   1 
ATOM   3402 O  O   . LEU A 1 415 ? -33.462 18.368 44.73  1 32.96   ? 433  LEU A O   1 
ATOM   3403 C  CB  . LEU A 1 415 ? -35.387 15.731 45.241 1 32.086  ? 433  LEU A CB  1 
ATOM   3404 C  CG  . LEU A 1 415 ? -34.147 15.35  46.061 1 32.325  ? 433  LEU A CG  1 
ATOM   3405 C  CD1 . LEU A 1 415 ? -34.148 15.978 47.436 1 32.763  ? 433  LEU A CD1 1 
ATOM   3406 C  CD2 . LEU A 1 415 ? -34.018 13.839 46.198 1 34.22   ? 433  LEU A CD2 1 
ATOM   3407 N  N   . THR A 1 416 ? -34.2   17.429 42.814 1 32.312  ? 434  THR A N   1 
ATOM   3408 C  CA  . THR A 1 416 ? -33.061 17.85  42.016 1 30.774  ? 434  THR A CA  1 
ATOM   3409 C  C   . THR A 1 416 ? -33.091 19.376 41.842 1 31.726  ? 434  THR A C   1 
ATOM   3410 O  O   . THR A 1 416 ? -32.047 20.042 41.907 1 29.647  ? 434  THR A O   1 
ATOM   3411 C  CB  . THR A 1 416 ? -33.048 17.087 40.689 1 34.196  ? 434  THR A CB  1 
ATOM   3412 O  OG1 . THR A 1 416 ? -33.006 15.694 41.015 1 35.016  ? 434  THR A OG1 1 
ATOM   3413 C  CG2 . THR A 1 416 ? -31.857 17.435 39.808 1 31.788  ? 434  THR A CG2 1 
ATOM   3414 N  N   . ALA A 1 417 ? -34.286 19.946 41.667 1 29.086  ? 435  ALA A N   1 
ATOM   3415 C  CA  . ALA A 1 417 ? -34.439 21.388 41.513 1 28.07   ? 435  ALA A CA  1 
ATOM   3416 C  C   . ALA A 1 417 ? -34.022 22.135 42.785 1 26.226  ? 435  ALA A C   1 
ATOM   3417 O  O   . ALA A 1 417 ? -33.468 23.226 42.705 1 28.537  ? 435  ALA A O   1 
ATOM   3418 C  CB  . ALA A 1 417 ? -35.857 21.703 41.117 1 29.021  ? 435  ALA A CB  1 
ATOM   3419 N  N   . LEU A 1 418 ? -34.215 21.521 43.953 1 27.147  ? 436  LEU A N   1 
ATOM   3420 C  CA  . LEU A 1 418 ? -33.821 22.129 45.214 1 28.767  ? 436  LEU A CA  1 
ATOM   3421 C  C   . LEU A 1 418 ? -32.298 22.236 45.327 1 34.123  ? 436  LEU A C   1 
ATOM   3422 O  O   . LEU A 1 418 ? -31.803 23.043 46.114 1 36.599  ? 436  LEU A O   1 
ATOM   3423 C  CB  . LEU A 1 418 ? -34.385 21.344 46.389 1 27.304  ? 436  LEU A CB  1 
ATOM   3424 C  CG  . LEU A 1 418 ? -35.91  21.341 46.577 1 32.253  ? 436  LEU A CG  1 
ATOM   3425 C  CD1 . LEU A 1 418 ? -36.265 20.406 47.735 1 34.49   ? 436  LEU A CD1 1 
ATOM   3426 C  CD2 . LEU A 1 418 ? -36.549 22.693 46.821 1 32.219  ? 436  LEU A CD2 1 
ATOM   3427 N  N   . ASP A 1 419 ? -31.565 21.402 44.576 1 36.013  ? 437  ASP A N   1 
ATOM   3428 C  CA  . ASP A 1 419 ? -30.109 21.484 44.492 1 38.532  ? 437  ASP A CA  1 
ATOM   3429 C  C   . ASP A 1 419 ? -29.681 22.34  43.288 1 37.449  ? 437  ASP A C   1 
ATOM   3430 O  O   . ASP A 1 419 ? -28.691 23.062 43.378 1 42.533  ? 437  ASP A O   1 
ATOM   3431 C  CB  . ASP A 1 419 ? -29.46  20.105 44.369 1 44.928  ? 437  ASP A CB  1 
ATOM   3432 C  CG  . ASP A 1 419 ? -29.491 19.157 45.574 1 59.758  ? 437  ASP A CG  1 
ATOM   3433 O  OD1 . ASP A 1 419 ? -29.296 19.657 46.728 1 52.941  ? 437  ASP A OD1 1 
ATOM   3434 O  OD2 . ASP A 1 419 ? -29.642 17.901 45.346 1 67.418  ? 437  ASP A OD2 1 
ATOM   3435 N  N   . LYS A 1 420 ? -30.397 22.248 42.148 1 31.614  ? 438  LYS A N   1 
ATOM   3436 C  CA  . LYS A 1 420 ? -29.874 22.728 40.874 1 32.008  ? 438  LYS A CA  1 
ATOM   3437 C  C   . LYS A 1 420 ? -30.488 24.062 40.434 1 33.374  ? 438  LYS A C   1 
ATOM   3438 O  O   . LYS A 1 420 ? -29.772 24.904 39.903 1 33.374  ? 438  LYS A O   1 
ATOM   3439 C  CB  . LYS A 1 420 ? -30.016 21.737 39.715 1 32.853  ? 438  LYS A CB  1 
ATOM   3440 C  CG  . LYS A 1 420 ? -29.244 20.421 39.843 1 34.741  ? 438  LYS A CG  1 
ATOM   3441 C  CD  . LYS A 1 420 ? -27.728 20.52  39.937 1 37.873  ? 438  LYS A CD  1 
ATOM   3442 C  CE  . LYS A 1 420 ? -27.054 19.241 40.339 1 42.11   ? 438  LYS A CE  1 
ATOM   3443 N  NZ  . LYS A 1 420 ? -25.602 19.468 40.339 1 46.184  ? 438  LYS A NZ  1 
ATOM   3444 N  N   . ILE A 1 421 ? -31.799 24.265 40.579 1 30.507  ? 439  ILE A N   1 
ATOM   3445 C  CA  . ILE A 1 421 ? -32.357 25.559 40.188 1 32.504  ? 439  ILE A CA  1 
ATOM   3446 C  C   . ILE A 1 421 ? -32.093 26.575 41.303 1 27.986  ? 439  ILE A C   1 
ATOM   3447 O  O   . ILE A 1 421 ? -31.663 27.688 41.046 1 28.478  ? 439  ILE A O   1 
ATOM   3448 C  CB  . ILE A 1 421 ? -33.854 25.474 39.826 1 29.231  ? 439  ILE A CB  1 
ATOM   3449 C  CG1 . ILE A 1 421 ? -34.116 24.497 38.687 1 30.174  ? 439  ILE A CG1 1 
ATOM   3450 C  CG2 . ILE A 1 421 ? -34.426 26.852 39.508 1 31.28   ? 439  ILE A CG2 1 
ATOM   3451 C  CD1 . ILE A 1 421 ? -33.404 24.837 37.395 1 31.75   ? 439  ILE A CD1 1 
ATOM   3452 N  N   . VAL A 1 422 ? -32.354 26.189 42.546 1 28.028  ? 440  VAL A N   1 
ATOM   3453 C  CA  . VAL A 1 422 ? -32.229 27.097 43.681 1 27.761  ? 440  VAL A CA  1 
ATOM   3454 C  C   . VAL A 1 422 ? -30.852 27.744 43.776 1 27.829  ? 440  VAL A C   1 
ATOM   3455 O  O   . VAL A 1 422 ? -30.712 28.888 44.18  1 31.309  ? 440  VAL A O   1 
ATOM   3456 C  CB  . VAL A 1 422 ? -32.53  26.28  44.93  1 28.216  ? 440  VAL A CB  1 
ATOM   3457 C  CG1 . VAL A 1 422 ? -31.96  26.925 46.174 1 31.719  ? 440  VAL A CG1 1 
ATOM   3458 C  CG2 . VAL A 1 422 ? -34.031 26.077 45.069 1 29.831  ? 440  VAL A CG2 1 
ATOM   3459 N  N   . PHE A 1 423 ? -29.833 26.987 43.414 1 30.085  ? 441  PHE A N   1 
ATOM   3460 C  CA  . PHE A 1 423 ? -28.452 27.409 43.512 1 27.986  ? 441  PHE A CA  1 
ATOM   3461 C  C   . PHE A 1 423 ? -28.119 28.518 42.533 1 26.003  ? 441  PHE A C   1 
ATOM   3462 O  O   . PHE A 1 423 ? -27.157 29.235 42.766 1 27.81   ? 441  PHE A O   1 
ATOM   3463 C  CB  . PHE A 1 423 ? -27.592 26.176 43.193 1 27.714  ? 441  PHE A CB  1 
ATOM   3464 C  CG  . PHE A 1 423 ? -26.096 26.419 43.27  1 25.764  ? 441  PHE A CG  1 
ATOM   3465 C  CD1 . PHE A 1 423 ? -25.452 26.471 44.496 1 26.123  ? 441  PHE A CD1 1 
ATOM   3466 C  CD2 . PHE A 1 423 ? -25.342 26.583 42.114 1 26.472  ? 441  PHE A CD2 1 
ATOM   3467 C  CE1 . PHE A 1 423 ? -24.082 26.633 44.558 1 25.144  ? 441  PHE A CE1 1 
ATOM   3468 C  CE2 . PHE A 1 423 ? -23.988 26.817 42.193 1 25.28   ? 441  PHE A CE2 1 
ATOM   3469 C  CZ  . PHE A 1 423 ? -23.363 26.823 43.411 1 25.219  ? 441  PHE A CZ  1 
ATOM   3470 N  N   . LEU A 1 424 ? -28.847 28.63  41.422 1 24.191  ? 442  LEU A N   1 
ATOM   3471 C  CA  . LEU A 1 424 ? -28.421 29.554 40.378 1 29.533  ? 442  LEU A CA  1 
ATOM   3472 C  C   . LEU A 1 424 ? -28.381 31.004 40.882 1 29.505  ? 442  LEU A C   1 
ATOM   3473 O  O   . LEU A 1 424 ? -27.364 31.696 40.731 1 28.103  ? 442  LEU A O   1 
ATOM   3474 C  CB  . LEU A 1 424 ? -29.279 29.415 39.122 1 29.8    ? 442  LEU A CB  1 
ATOM   3475 C  CG  . LEU A 1 424 ? -29.294 28.019 38.494 1 30.665  ? 442  LEU A CG  1 
ATOM   3476 C  CD1 . LEU A 1 424 ? -30.199 27.972 37.282 1 33.883  ? 442  LEU A CD1 1 
ATOM   3477 C  CD2 . LEU A 1 424 ? -27.916 27.578 38.101 1 30.221  ? 442  LEU A CD2 1 
ATOM   3478 N  N   . PRO A 1 425 ? -29.482 31.538 41.456 1 27.096  ? 443  PRO A N   1 
ATOM   3479 C  CA  . PRO A 1 425 ? -29.456 32.898 41.978 1 28.914  ? 443  PRO A CA  1 
ATOM   3480 C  C   . PRO A 1 425 ? -28.387 33.076 43.051 1 27.882  ? 443  PRO A C   1 
ATOM   3481 O  O   . PRO A 1 425 ? -27.712 34.102 43.095 1 25.143  ? 443  PRO A O   1 
ATOM   3482 C  CB  . PRO A 1 425 ? -30.885 33.155 42.498 1 28.292  ? 443  PRO A CB  1 
ATOM   3483 C  CG  . PRO A 1 425 ? -31.558 31.803 42.506 1 29.534  ? 443  PRO A CG  1 
ATOM   3484 C  CD  . PRO A 1 425 ? -30.794 30.891 41.584 1 28.954  ? 443  PRO A CD  1 
ATOM   3485 N  N   . PHE A 1 426 ? -28.237 32.047 43.892 1 27.023  ? 444  PHE A N   1 
ATOM   3486 C  CA  . PHE A 1 426 ? -27.235 32.077 44.944 1 29.862  ? 444  PHE A CA  1 
ATOM   3487 C  C   . PHE A 1 426 ? -25.856 32.3   44.334 1 26.522  ? 444  PHE A C   1 
ATOM   3488 O  O   . PHE A 1 426 ? -25.131 33.189 44.752 1 27.016  ? 444  PHE A O   1 
ATOM   3489 C  CB  . PHE A 1 426 ? -27.227 30.799 45.78  1 28.276  ? 444  PHE A CB  1 
ATOM   3490 C  CG  . PHE A 1 426 ? -26.055 30.774 46.734 1 26.907  ? 444  PHE A CG  1 
ATOM   3491 C  CD1 . PHE A 1 426 ? -26.14  31.4   47.964 1 27.313  ? 444  PHE A CD1 1 
ATOM   3492 C  CD2 . PHE A 1 426 ? -24.874 30.122 46.391 1 27.908  ? 444  PHE A CD2 1 
ATOM   3493 C  CE1 . PHE A 1 426 ? -25.067 31.389 48.833 1 26.553  ? 444  PHE A CE1 1 
ATOM   3494 C  CE2 . PHE A 1 426 ? -23.807 30.087 47.268 1 26.081  ? 444  PHE A CE2 1 
ATOM   3495 C  CZ  . PHE A 1 426 ? -23.9   30.731 48.484 1 28.159  ? 444  PHE A CZ  1 
ATOM   3496 N  N   . ALA A 1 427 ? -25.5   31.481 43.35  1 28.121  ? 445  ALA A N   1 
ATOM   3497 C  CA  . ALA A 1 427 ? -24.162 31.505 42.797 1 26.177  ? 445  ALA A CA  1 
ATOM   3498 C  C   . ALA A 1 427 ? -23.93  32.829 42.097 1 27.976  ? 445  ALA A C   1 
ATOM   3499 O  O   . ALA A 1 427 ? -22.831 33.386 42.152 1 30.228  ? 445  ALA A O   1 
ATOM   3500 C  CB  . ALA A 1 427 ? -23.938 30.349 41.884 1 26.397  ? 445  ALA A CB  1 
ATOM   3501 N  N   . PHE A 1 428 ? -24.974 33.347 41.46  1 30.445  ? 446  PHE A N   1 
ATOM   3502 C  CA  . PHE A 1 428 ? -24.84  34.61  40.746 1 29.417  ? 446  PHE A CA  1 
ATOM   3503 C  C   . PHE A 1 428 ? -24.506 35.733 41.737 1 28.992  ? 446  PHE A C   1 
ATOM   3504 O  O   . PHE A 1 428 ? -23.646 36.57  41.447 1 28.687  ? 446  PHE A O   1 
ATOM   3505 C  CB  . PHE A 1 428 ? -26.118 34.931 39.965 1 27.845  ? 446  PHE A CB  1 
ATOM   3506 C  CG  . PHE A 1 428 ? -25.866 35.68  38.674 1 28.168  ? 446  PHE A CG  1 
ATOM   3507 C  CD1 . PHE A 1 428 ? -24.591 36.153 38.343 1 31.745  ? 446  PHE A CD1 1 
ATOM   3508 C  CD2 . PHE A 1 428 ? -26.906 35.92  37.795 1 29.786  ? 446  PHE A CD2 1 
ATOM   3509 C  CE1 . PHE A 1 428 ? -24.356 36.851 37.156 1 30.168  ? 446  PHE A CE1 1 
ATOM   3510 C  CE2 . PHE A 1 428 ? -26.669 36.614 36.608 1 32.472  ? 446  PHE A CE2 1 
ATOM   3511 C  CZ  . PHE A 1 428 ? -25.394 37.059 36.283 1 33.471  ? 446  PHE A CZ  1 
ATOM   3512 N  N   . THR A 1 429 ? -25.188 35.747 42.9   1 29.197  ? 447  THR A N   1 
ATOM   3513 C  CA  . THR A 1 429 ? -25.048 36.843 43.857 1 30.69   ? 447  THR A CA  1 
ATOM   3514 C  C   . THR A 1 429 ? -23.661 36.877 44.485 1 28.306  ? 447  THR A C   1 
ATOM   3515 O  O   . THR A 1 429 ? -23.205 37.964 44.824 1 34.556  ? 447  THR A O   1 
ATOM   3516 C  CB  . THR A 1 429 ? -26.094 36.851 44.969 1 29.461  ? 447  THR A CB  1 
ATOM   3517 O  OG1 . THR A 1 429 ? -26.03  35.584 45.617 1 31.103  ? 447  THR A OG1 1 
ATOM   3518 C  CG2 . THR A 1 429 ? -27.482 37.139 44.439 1 29.962  ? 447  THR A CG2 1 
ATOM   3519 N  N   . MET A 1 430 ? -23.02  35.719 44.671 1 28.493  ? 448  MET A N   1 
ATOM   3520 C  CA  . MET A 1 430 ? -21.696 35.673 45.283 1 29.185  ? 448  MET A CA  1 
ATOM   3521 C  C   . MET A 1 430 ? -20.709 36.497 44.455 1 27.514  ? 448  MET A C   1 
ATOM   3522 O  O   . MET A 1 430 ? -19.914 37.24  45     1 28.519  ? 448  MET A O   1 
ATOM   3523 C  CB  . MET A 1 430 ? -21.14  34.248 45.427 1 30.1    ? 448  MET A CB  1 
ATOM   3524 C  CG  . MET A 1 430 ? -21.893 33.341 46.392 1 29.71   ? 448  MET A CG  1 
ATOM   3525 S  SD  . MET A 1 430 ? -21.934 33.92  48.101 1 30.476  ? 448  MET A SD  1 
ATOM   3526 C  CE  . MET A 1 430 ? -23.579 34.653 48.094 1 33.071  ? 448  MET A CE  1 
ATOM   3527 N  N   . ASP A 1 431 ? -20.743 36.383 43.127 1 31.415  ? 449  ASP A N   1 
ATOM   3528 C  CA  . ASP A 1 431 ? -19.821 37.166 42.322 1 29.043  ? 449  ASP A CA  1 
ATOM   3529 C  C   . ASP A 1 431 ? -20.359 38.569 42.056 1 30.499  ? 449  ASP A C   1 
ATOM   3530 O  O   . ASP A 1 431 ? -19.557 39.499 41.973 1 27.32   ? 449  ASP A O   1 
ATOM   3531 C  CB  . ASP A 1 431 ? -19.305 36.399 41.119 1 28.704  ? 449  ASP A CB  1 
ATOM   3532 C  CG  . ASP A 1 431 ? -18.123 35.509 41.476 1 29.162  ? 449  ASP A CG  1 
ATOM   3533 O  OD1 . ASP A 1 431 ? -17.857 35.363 42.703 1 27.067  ? 449  ASP A OD1 1 
ATOM   3534 O  OD2 . ASP A 1 431 ? -17.45  35.021 40.544 1 25.538  ? 449  ASP A OD2 1 
ATOM   3535 N  N   . LYS A 1 432 ? -21.684 38.74  41.955 1 28.556  ? 450  LYS A N   1 
ATOM   3536 C  CA  . LYS A 1 432 ? -22.226 40.074 41.78  1 30.76   ? 450  LYS A CA  1 
ATOM   3537 C  C   . LYS A 1 432 ? -21.798 40.962 42.949 1 28.161  ? 450  LYS A C   1 
ATOM   3538 O  O   . LYS A 1 432 ? -21.462 42.13  42.749 1 26.401  ? 450  LYS A O   1 
ATOM   3539 C  CB  . LYS A 1 432 ? -23.751 40.064 41.612 1 33.693  ? 450  LYS A CB  1 
ATOM   3540 C  CG  . LYS A 1 432 ? -24.233 39.789 40.187 1 34.817  ? 450  LYS A CG  1 
ATOM   3541 C  CD  . LYS A 1 432 ? -25.722 39.473 40.127 1 38.577  ? 450  LYS A CD  1 
ATOM   3542 C  CE  . LYS A 1 432 ? -26.27  39.428 38.736 1 42.935  ? 450  LYS A CE  1 
ATOM   3543 N  NZ  . LYS A 1 432 ? -26.257 40.734 38.067 1 44.44   ? 450  LYS A NZ  1 
ATOM   3544 N  N   . TYR A 1 433 ? -21.835 40.409 44.166 1 24.491  ? 451  TYR A N   1 
ATOM   3545 C  CA  . TYR A 1 433 ? -21.445 41.169 45.328 1 24.084  ? 451  TYR A CA  1 
ATOM   3546 C  C   . TYR A 1 433 ? -19.989 41.566 45.164 1 27.115  ? 451  TYR A C   1 
ATOM   3547 O  O   . TYR A 1 433 ? -19.668 42.746 45.211 1 26.628  ? 451  TYR A O   1 
ATOM   3548 C  CB  . TYR A 1 433 ? -21.666 40.352 46.599 1 25.827  ? 451  TYR A CB  1 
ATOM   3549 C  CG  . TYR A 1 433 ? -21.227 41.05  47.886 1 28.081  ? 451  TYR A CG  1 
ATOM   3550 C  CD1 . TYR A 1 433 ? -21.894 42.18  48.348 1 28.879  ? 451  TYR A CD1 1 
ATOM   3551 C  CD2 . TYR A 1 433 ? -20.173 40.566 48.656 1 27.396  ? 451  TYR A CD2 1 
ATOM   3552 C  CE1 . TYR A 1 433 ? -21.538 42.803 49.532 1 28.282  ? 451  TYR A CE1 1 
ATOM   3553 C  CE2 . TYR A 1 433 ? -19.797 41.19  49.837 1 30.135  ? 451  TYR A CE2 1 
ATOM   3554 C  CZ  . TYR A 1 433 ? -20.48  42.313 50.272 1 29.247  ? 451  TYR A CZ  1 
ATOM   3555 O  OH  . TYR A 1 433 ? -20.156 42.908 51.439 1 32.392  ? 451  TYR A OH  1 
ATOM   3556 N  N   . ARG A 1 434 ? -19.112 40.57  44.95  1 28.257  ? 452  ARG A N   1 
ATOM   3557 C  CA  . ARG A 1 434 ? -17.681 40.833 44.941 1 27.93   ? 452  ARG A CA  1 
ATOM   3558 C  C   . ARG A 1 434 ? -17.323 41.767 43.796 1 27.625  ? 452  ARG A C   1 
ATOM   3559 O  O   . ARG A 1 434 ? -16.443 42.609 43.942 1 26.266  ? 452  ARG A O   1 
ATOM   3560 C  CB  . ARG A 1 434 ? -16.817 39.568 44.909 1 26.69   ? 452  ARG A CB  1 
ATOM   3561 C  CG  . ARG A 1 434 ? -16.832 38.917 46.283 1 25.887  ? 452  ARG A CG  1 
ATOM   3562 C  CD  . ARG A 1 434 ? -15.957 37.712 46.306 1 26.86   ? 452  ARG A CD  1 
ATOM   3563 N  NE  . ARG A 1 434 ? -16.543 36.566 45.614 1 28.094  ? 452  ARG A NE  1 
ATOM   3564 C  CZ  . ARG A 1 434 ? -15.955 35.374 45.573 1 30      ? 452  ARG A CZ  1 
ATOM   3565 N  NH1 . ARG A 1 434 ? -14.912 35.119 46.357 1 27.189  ? 452  ARG A NH1 1 
ATOM   3566 N  NH2 . ARG A 1 434 ? -16.423 34.437 44.752 1 29.112  ? 452  ARG A NH2 1 
ATOM   3567 N  N   . TRP A 1 435 ? -17.988 41.587 42.655 1 26.935  ? 453  TRP A N   1 
ATOM   3568 C  CA  . TRP A 1 435 ? -17.695 42.412 41.509 1 26.107  ? 453  TRP A CA  1 
ATOM   3569 C  C   . TRP A 1 435 ? -17.955 43.859 41.894 1 26.186  ? 453  TRP A C   1 
ATOM   3570 O  O   . TRP A 1 435 ? -17.254 44.762 41.467 1 28.972  ? 453  TRP A O   1 
ATOM   3571 C  CB  . TRP A 1 435 ? -18.573 42.054 40.307 1 26.503  ? 453  TRP A CB  1 
ATOM   3572 C  CG  . TRP A 1 435 ? -18.261 40.767 39.615 1 28.847  ? 453  TRP A CG  1 
ATOM   3573 C  CD1 . TRP A 1 435 ? -17.165 39.968 39.758 1 33.481  ? 453  TRP A CD1 1 
ATOM   3574 C  CD2 . TRP A 1 435 ? -19.115 40.128 38.65  1 33.228  ? 453  TRP A CD2 1 
ATOM   3575 N  NE1 . TRP A 1 435 ? -17.272 38.886 38.932 1 33.744  ? 453  TRP A NE1 1 
ATOM   3576 C  CE2 . TRP A 1 435 ? -18.455 38.95  38.246 1 34.724  ? 453  TRP A CE2 1 
ATOM   3577 C  CE3 . TRP A 1 435 ? -20.368 40.43  38.103 1 34.565  ? 453  TRP A CE3 1 
ATOM   3578 C  CZ2 . TRP A 1 435 ? -19.021 38.066 37.332 1 36.312  ? 453  TRP A CZ2 1 
ATOM   3579 C  CZ3 . TRP A 1 435 ? -20.924 39.556 37.2   1 36.942  ? 453  TRP A CZ3 1 
ATOM   3580 C  CH2 . TRP A 1 435 ? -20.259 38.389 36.828 1 39.396  ? 453  TRP A CH2 1 
ATOM   3581 N  N   . SER A 1 436 ? -19.033 44.056 42.638 1 27.066  ? 454  SER A N   1 
ATOM   3582 C  CA  . SER A 1 436 ? -19.503 45.399 42.898 1 27.412  ? 454  SER A CA  1 
ATOM   3583 C  C   . SER A 1 436 ? -18.55  46.09  43.871 1 32.513  ? 454  SER A C   1 
ATOM   3584 O  O   . SER A 1 436 ? -18.361 47.291 43.732 1 31.973  ? 454  SER A O   1 
ATOM   3585 C  CB  . SER A 1 436 ? -20.936 45.41  43.355 1 25.51   ? 454  SER A CB  1 
ATOM   3586 O  OG  . SER A 1 436 ? -21.088 45.096 44.733 1 27.654  ? 454  SER A OG  1 
ATOM   3587 N  N   . LEU A 1 437 ? -17.894 45.331 44.776 1 32.199  ? 455  LEU A N   1 
ATOM   3588 C  CA  . LEU A 1 437 ? -16.861 45.888 45.643 1 27.667  ? 455  LEU A CA  1 
ATOM   3589 C  C   . LEU A 1 437 ? -15.578 46.138 44.857 1 29.791  ? 455  LEU A C   1 
ATOM   3590 O  O   . LEU A 1 437 ? -14.966 47.206 44.973 1 28.385  ? 455  LEU A O   1 
ATOM   3591 C  CB  . LEU A 1 437 ? -16.554 44.976 46.814 1 27.424  ? 455  LEU A CB  1 
ATOM   3592 C  CG  . LEU A 1 437 ? -17.726 44.502 47.666 1 28.716  ? 455  LEU A CG  1 
ATOM   3593 C  CD1 . LEU A 1 437 ? -17.169 43.813 48.9   1 32.104  ? 455  LEU A CD1 1 
ATOM   3594 C  CD2 . LEU A 1 437 ? -18.655 45.595 48.055 1 32.132  ? 455  LEU A CD2 1 
ATOM   3595 N  N   . PHE A 1 438 ? -15.18  45.136 44.048 1 30.799  ? 456  PHE A N   1 
ATOM   3596 C  CA  . PHE A 1 438 ? -13.971 45.213 43.242 1 29.566  ? 456  PHE A CA  1 
ATOM   3597 C  C   . PHE A 1 438 ? -13.996 46.446 42.338 1 31.968  ? 456  PHE A C   1 
ATOM   3598 O  O   . PHE A 1 438 ? -12.971 47.108 42.187 1 32.144  ? 456  PHE A O   1 
ATOM   3599 C  CB  . PHE A 1 438 ? -13.776 43.951 42.397 1 30.674  ? 456  PHE A CB  1 
ATOM   3600 C  CG  . PHE A 1 438 ? -13.401 42.673 43.143 1 31.209  ? 456  PHE A CG  1 
ATOM   3601 C  CD1 . PHE A 1 438 ? -12.973 42.686 44.467 1 31.772  ? 456  PHE A CD1 1 
ATOM   3602 C  CD2 . PHE A 1 438 ? -13.449 41.445 42.494 1 34.875  ? 456  PHE A CD2 1 
ATOM   3603 C  CE1 . PHE A 1 438 ? -12.635 41.517 45.125 1 32.336  ? 456  PHE A CE1 1 
ATOM   3604 C  CE2 . PHE A 1 438 ? -13.105 40.275 43.154 1 32.626  ? 456  PHE A CE2 1 
ATOM   3605 C  CZ  . PHE A 1 438 ? -12.691 40.319 44.466 1 32.556  ? 456  PHE A CZ  1 
ATOM   3606 N  N   . ARG A 1 439 ? -15.15  46.705 41.703 1 33.929  ? 457  ARG A N   1 
ATOM   3607 C  CA  . ARG A 1 439 ? -15.324 47.794 40.746 1 32.592  ? 457  ARG A CA  1 
ATOM   3608 C  C   . ARG A 1 439 ? -15.522 49.152 41.424 1 31.51   ? 457  ARG A C   1 
ATOM   3609 O  O   . ARG A 1 439 ? -15.539 50.153 40.748 1 30.875  ? 457  ARG A O   1 
ATOM   3610 C  CB  . ARG A 1 439 ? -16.6   47.563 39.935 1 32.445  ? 457  ARG A CB  1 
ATOM   3611 C  CG  . ARG A 1 439 ? -16.417 46.501 38.87  1 33.222  ? 457  ARG A CG  1 
ATOM   3612 C  CD  . ARG A 1 439 ? -17.721 46.092 38.245 1 29.91   ? 457  ARG A CD  1 
ATOM   3613 N  NE  . ARG A 1 439 ? -17.346 45.25  37.106 1 29.773  ? 457  ARG A NE  1 
ATOM   3614 C  CZ  . ARG A 1 439 ? -18.156 44.369 36.551 1 30.152  ? 457  ARG A CZ  1 
ATOM   3615 N  NH1 . ARG A 1 439 ? -19.365 44.144 37.058 1 27.984  ? 457  ARG A NH1 1 
ATOM   3616 N  NH2 . ARG A 1 439 ? -17.724 43.693 35.51  1 31.716  ? 457  ARG A NH2 1 
ATOM   3617 N  N   . GLY A 1 440 ? -15.734 49.187 42.741 1 32.644  ? 458  GLY A N   1 
ATOM   3618 C  CA  . GLY A 1 440 ? -15.831 50.434 43.485 1 32.383  ? 458  GLY A CA  1 
ATOM   3619 C  C   . GLY A 1 440 ? -17.238 51.039 43.435 1 34.52   ? 458  GLY A C   1 
ATOM   3620 O  O   . GLY A 1 440 ? -17.389 52.249 43.438 1 36.212  ? 458  GLY A O   1 
ATOM   3621 N  N   . GLU A 1 441 ? -18.267 50.2   43.41  1 32.038  ? 459  GLU A N   1 
ATOM   3622 C  CA  . GLU A 1 441 ? -19.629 50.651 43.19  1 34.87   ? 459  GLU A CA  1 
ATOM   3623 C  C   . GLU A 1 441 ? -20.39  50.795 44.499 1 32.654  ? 459  GLU A C   1 
ATOM   3624 O  O   . GLU A 1 441 ? -21.472 51.329 44.473 1 35.101  ? 459  GLU A O   1 
ATOM   3625 C  CB  . GLU A 1 441 ? -20.377 49.701 42.251 1 36.014  ? 459  GLU A CB  1 
ATOM   3626 C  CG  . GLU A 1 441 ? -19.913 49.842 40.803 1 38.163  ? 459  GLU A CG  1 
ATOM   3627 C  CD  . GLU A 1 441 ? -20.322 48.709 39.864 1 46.224  ? 459  GLU A CD  1 
ATOM   3628 O  OE1 . GLU A 1 441 ? -20.982 47.772 40.391 1 48.202  ? 459  GLU A OE1 1 
ATOM   3629 O  OE2 . GLU A 1 441 ? -19.992 48.75  38.635 1 45.834  ? 459  GLU A OE2 1 
ATOM   3630 N  N   . VAL A 1 442 ? -19.836 50.347 45.628 1 34.034  ? 460  VAL A N   1 
ATOM   3631 C  CA  . VAL A 1 442 ? -20.5   50.424 46.912 1 32.977  ? 460  VAL A CA  1 
ATOM   3632 C  C   . VAL A 1 442 ? -19.544 51.114 47.879 1 37.958  ? 460  VAL A C   1 
ATOM   3633 O  O   . VAL A 1 442 ? -18.391 50.731 47.95  1 37.844  ? 460  VAL A O   1 
ATOM   3634 C  CB  . VAL A 1 442 ? -20.833 48.991 47.387 1 35.995  ? 460  VAL A CB  1 
ATOM   3635 C  CG1 . VAL A 1 442 ? -21.602 48.962 48.708 1 33.872  ? 460  VAL A CG1 1 
ATOM   3636 C  CG2 . VAL A 1 442 ? -21.607 48.19  46.345 1 39.703  ? 460  VAL A CG2 1 
ATOM   3637 N  N   . ASP A 1 443 ? -20.031 52.061 48.681 1 43.955  ? 461  ASP A N   1 
ATOM   3638 C  CA  . ASP A 1 443 ? -19.216 52.66  49.726 1 51.438  ? 461  ASP A CA  1 
ATOM   3639 C  C   . ASP A 1 443 ? -19.082 51.678 50.879 1 45.955  ? 461  ASP A C   1 
ATOM   3640 O  O   . ASP A 1 443 ? -20.062 51.021 51.215 1 43.329  ? 461  ASP A O   1 
ATOM   3641 C  CB  . ASP A 1 443 ? -19.831 53.945 50.27  1 61.966  ? 461  ASP A CB  1 
ATOM   3642 C  CG  . ASP A 1 443 ? -19.775 55.146 49.335 1 73.072  ? 461  ASP A CG  1 
ATOM   3643 O  OD1 . ASP A 1 443 ? -18.916 55.155 48.426 1 84.26   ? 461  ASP A OD1 1 
ATOM   3644 O  OD2 . ASP A 1 443 ? -20.599 56.067 49.512 1 88.597  ? 461  ASP A OD2 1 
ATOM   3645 N  N   . LYS A 1 444 ? -17.898 51.679 51.513 1 47.039  ? 462  LYS A N   1 
ATOM   3646 C  CA  . LYS A 1 444 ? -17.551 50.814 52.638 1 47.757  ? 462  LYS A CA  1 
ATOM   3647 C  C   . LYS A 1 444 ? -18.609 50.849 53.731 1 40.07   ? 462  LYS A C   1 
ATOM   3648 O  O   . LYS A 1 444 ? -18.821 49.86  54.438 1 39.607  ? 462  LYS A O   1 
ATOM   3649 C  CB  . LYS A 1 444 ? -16.182 51.189 53.225 1 50.378  ? 462  LYS A CB  1 
ATOM   3650 C  CG  . LYS A 1 444 ? -15.025 50.373 52.667 1 59.196  ? 462  LYS A CG  1 
ATOM   3651 C  CD  . LYS A 1 444 ? -13.872 51.199 52.109 1 71.433  ? 462  LYS A CD  1 
ATOM   3652 C  CE  . LYS A 1 444 ? -12.93  51.733 53.138 1 78.009  ? 462  LYS A CE  1 
ATOM   3653 N  NZ  . LYS A 1 444 ? -12.158 50.634 53.723 1 80.596  ? 462  LYS A NZ  1 
ATOM   3654 N  N   . ALA A 1 445 ? -19.274 51.992 53.856 1 38.378  ? 463  ALA A N   1 
ATOM   3655 C  CA  . ALA A 1 445 ? -20.316 52.157 54.856 1 39.78   ? 463  ALA A CA  1 
ATOM   3656 C  C   . ALA A 1 445 ? -21.537 51.281 54.56  1 37.952  ? 463  ALA A C   1 
ATOM   3657 O  O   . ALA A 1 445 ? -22.312 51.027 55.481 1 42.249  ? 463  ALA A O   1 
ATOM   3658 C  CB  . ALA A 1 445 ? -20.699 53.627 54.936 1 41.564  ? 463  ALA A CB  1 
ATOM   3659 N  N   . ASN A 1 446 ? -21.701 50.817 53.304 1 34.016  ? 464  ASN A N   1 
ATOM   3660 C  CA  . ASN A 1 446 ? -22.869 50.039 52.904 1 36.168  ? 464  ASN A CA  1 
ATOM   3661 C  C   . ASN A 1 446 ? -22.557 48.591 52.488 1 34.816  ? 464  ASN A C   1 
ATOM   3662 O  O   . ASN A 1 446 ? -23.397 47.947 51.853 1 37.503  ? 464  ASN A O   1 
ATOM   3663 C  CB  . ASN A 1 446 ? -23.585 50.7   51.727 1 39.304  ? 464  ASN A CB  1 
ATOM   3664 C  CG  . ASN A 1 446 ? -23.889 52.156 51.983 1 39.167  ? 464  ASN A CG  1 
ATOM   3665 O  OD1 . ASN A 1 446 ? -23.574 53.022 51.16  1 41.317  ? 464  ASN A OD1 1 
ATOM   3666 N  ND2 . ASN A 1 446 ? -24.476 52.442 53.126 1 36.31   ? 464  ASN A ND2 1 
ATOM   3667 N  N   . TRP A 1 447 ? -21.369 48.066 52.82  1 30.959  ? 465  TRP A N   1 
ATOM   3668 C  CA  . TRP A 1 447 ? -20.945 46.78  52.296 1 29.652  ? 465  TRP A CA  1 
ATOM   3669 C  C   . TRP A 1 447 ? -21.808 45.628 52.799 1 28.571  ? 465  TRP A C   1 
ATOM   3670 O  O   . TRP A 1 447 ? -22.037 44.702 52.052 1 30.514  ? 465  TRP A O   1 
ATOM   3671 C  CB  . TRP A 1 447 ? -19.476 46.505 52.623 1 32.314  ? 465  TRP A CB  1 
ATOM   3672 C  CG  . TRP A 1 447 ? -18.504 47.118 51.668 1 28.832  ? 465  TRP A CG  1 
ATOM   3673 C  CD1 . TRP A 1 447 ? -18.73  48.106 50.765 1 31.545  ? 465  TRP A CD1 1 
ATOM   3674 C  CD2 . TRP A 1 447 ? -17.12  46.778 51.554 1 29.312  ? 465  TRP A CD2 1 
ATOM   3675 N  NE1 . TRP A 1 447 ? -17.572 48.42  50.104 1 30.748  ? 465  TRP A NE1 1 
ATOM   3676 C  CE2 . TRP A 1 447 ? -16.572 47.613 50.558 1 29.724  ? 465  TRP A CE2 1 
ATOM   3677 C  CE3 . TRP A 1 447 ? -16.301 45.857 52.204 1 32.75   ? 465  TRP A CE3 1 
ATOM   3678 C  CZ2 . TRP A 1 447 ? -15.238 47.552 50.175 1 33.126  ? 465  TRP A CZ2 1 
ATOM   3679 C  CZ3 . TRP A 1 447 ? -14.978 45.797 51.834 1 36.205  ? 465  TRP A CZ3 1 
ATOM   3680 C  CH2 . TRP A 1 447 ? -14.458 46.631 50.828 1 38.091  ? 465  TRP A CH2 1 
ATOM   3681 N  N   . ASN A 1 448 ? -22.232 45.617 54.06  1 27.334  ? 466  ASN A N   1 
ATOM   3682 C  CA  . ASN A 1 448 ? -22.967 44.461 54.539 1 29.572  ? 466  ASN A CA  1 
ATOM   3683 C  C   . ASN A 1 448 ? -24.377 44.455 53.966 1 33.06   ? 466  ASN A C   1 
ATOM   3684 O  O   . ASN A 1 448 ? -24.866 43.4   53.555 1 32.13   ? 466  ASN A O   1 
ATOM   3685 C  CB  . ASN A 1 448 ? -23.089 44.339 56.053 1 30.221  ? 466  ASN A CB  1 
ATOM   3686 C  CG  . ASN A 1 448 ? -23.383 42.911 56.442 1 32.386  ? 466  ASN A CG  1 
ATOM   3687 O  OD1 . ASN A 1 448 ? -22.807 41.98  55.878 1 31.178  ? 466  ASN A OD1 1 
ATOM   3688 N  ND2 . ASN A 1 448 ? -24.291 42.692 57.375 1 36.073  ? 466  ASN A ND2 1 
ATOM   3689 N  N   . CYS A 1 449 ? -25.039 45.615 53.968 1 33.662  ? 467  CYS A N   1 
ATOM   3690 C  CA  . CYS A 1 449 ? -26.416 45.676 53.5   1 36.286  ? 467  CYS A CA  1 
ATOM   3691 C  C   . CYS A 1 449 ? -26.469 45.489 51.982 1 32.319  ? 467  CYS A C   1 
ATOM   3692 O  O   . CYS A 1 449 ? -27.468 44.979 51.494 1 31.269  ? 467  CYS A O   1 
ATOM   3693 C  CB  . CYS A 1 449 ? -27.158 46.899 54.043 1 46.343  ? 467  CYS A CB  1 
ATOM   3694 S  SG  . CYS A 1 449 ? -27.663 46.727 55.793 1 66.774  ? 467  CYS A SG  1 
ATOM   3695 N  N   . ALA A 1 450 ? -25.38  45.794 51.253 1 30.328  ? 468  ALA A N   1 
ATOM   3696 C  CA  . ALA A 1 450 ? -25.336 45.514 49.827 1 27.548  ? 468  ALA A CA  1 
ATOM   3697 C  C   . ALA A 1 450 ? -25.339 44.007 49.556 1 29.146  ? 468  ALA A C   1 
ATOM   3698 O  O   . ALA A 1 450 ? -25.812 43.573 48.513 1 29.092  ? 468  ALA A O   1 
ATOM   3699 C  CB  . ALA A 1 450 ? -24.131 46.152 49.208 1 25.645  ? 468  ALA A CB  1 
ATOM   3700 N  N   . PHE A 1 451 ? -24.799 43.216 50.491 1 28.519  ? 469  PHE A N   1 
ATOM   3701 C  CA  . PHE A 1 451 ? -24.786 41.767 50.375 1 27.57   ? 469  PHE A CA  1 
ATOM   3702 C  C   . PHE A 1 451 ? -26.22  41.247 50.503 1 28.073  ? 469  PHE A C   1 
ATOM   3703 O  O   . PHE A 1 451 ? -26.711 40.545 49.613 1 28.986  ? 469  PHE A O   1 
ATOM   3704 C  CB  . PHE A 1 451 ? -23.85  41.112 51.402 1 26.559  ? 469  PHE A CB  1 
ATOM   3705 C  CG  . PHE A 1 451 ? -23.802 39.59  51.387 1 25.367  ? 469  PHE A CG  1 
ATOM   3706 C  CD1 . PHE A 1 451 ? -23.148 38.9   50.37  1 28.195  ? 469  PHE A CD1 1 
ATOM   3707 C  CD2 . PHE A 1 451 ? -24.44  38.851 52.366 1 25.211  ? 469  PHE A CD2 1 
ATOM   3708 C  CE1 . PHE A 1 451 ? -23.098 37.517 50.357 1 26.39   ? 469  PHE A CE1 1 
ATOM   3709 C  CE2 . PHE A 1 451 ? -24.382 37.465 52.36  1 25.741  ? 469  PHE A CE2 1 
ATOM   3710 C  CZ  . PHE A 1 451 ? -23.686 36.805 51.369 1 26.829  ? 469  PHE A CZ  1 
ATOM   3711 N  N   . TRP A 1 452 ? -26.878 41.612 51.606 1 26.66   ? 470  TRP A N   1 
ATOM   3712 C  CA  . TRP A 1 452 ? -28.208 41.118 51.915 1 28.352  ? 470  TRP A CA  1 
ATOM   3713 C  C   . TRP A 1 452 ? -29.222 41.666 50.925 1 28.746  ? 470  TRP A C   1 
ATOM   3714 O  O   . TRP A 1 452 ? -30.192 40.977 50.629 1 28.951  ? 470  TRP A O   1 
ATOM   3715 C  CB  . TRP A 1 452 ? -28.583 41.404 53.38  1 26.357  ? 470  TRP A CB  1 
ATOM   3716 C  CG  . TRP A 1 452 ? -27.759 40.577 54.342 1 29.706  ? 470  TRP A CG  1 
ATOM   3717 C  CD1 . TRP A 1 452 ? -26.857 41.009 55.275 1 31.487  ? 470  TRP A CD1 1 
ATOM   3718 C  CD2 . TRP A 1 452 ? -27.694 39.138 54.387 1 26.152  ? 470  TRP A CD2 1 
ATOM   3719 N  NE1 . TRP A 1 452 ? -26.298 39.947 55.936 1 29.228  ? 470  TRP A NE1 1 
ATOM   3720 C  CE2 . TRP A 1 452 ? -26.773 38.79  55.396 1 27.686  ? 470  TRP A CE2 1 
ATOM   3721 C  CE3 . TRP A 1 452 ? -28.319 38.122 53.672 1 26.269  ? 470  TRP A CE3 1 
ATOM   3722 C  CZ2 . TRP A 1 452 ? -26.476 37.469 55.719 1 29.395  ? 470  TRP A CZ2 1 
ATOM   3723 C  CZ3 . TRP A 1 452 ? -27.998 36.816 53.966 1 28.847  ? 470  TRP A CZ3 1 
ATOM   3724 C  CH2 . TRP A 1 452 ? -27.105 36.492 54.989 1 29.015  ? 470  TRP A CH2 1 
ATOM   3725 N  N   . LYS A 1 453 ? -28.944 42.844 50.358 1 30.699  ? 471  LYS A N   1 
ATOM   3726 C  CA  . LYS A 1 453 ? -29.784 43.383 49.302 1 36.005  ? 471  LYS A CA  1 
ATOM   3727 C  C   . LYS A 1 453 ? -29.786 42.451 48.091 1 31.658  ? 471  LYS A C   1 
ATOM   3728 O  O   . LYS A 1 453 ? -30.844 42.121 47.561 1 29.308  ? 471  LYS A O   1 
ATOM   3729 C  CB  . LYS A 1 453 ? -29.399 44.804 48.891 1 44.773  ? 471  LYS A CB  1 
ATOM   3730 C  CG  . LYS A 1 453 ? -30.576 45.723 48.63  1 60.664  ? 471  LYS A CG  1 
ATOM   3731 C  CD  . LYS A 1 453 ? -30.21  47.054 47.971 1 78.465  ? 471  LYS A CD  1 
ATOM   3732 C  CE  . LYS A 1 453 ? -29.155 47.856 48.713 1 87.754  ? 471  LYS A CE  1 
ATOM   3733 N  NZ  . LYS A 1 453 ? -29.524 48.173 50.101 1 81.412  ? 471  LYS A NZ  1 
ATOM   3734 N  N   . LEU A 1 454 ? -28.607 41.999 47.653 1 32.506  ? 472  LEU A N   1 
ATOM   3735 C  CA  . LEU A 1 454 ? -28.529 41.103 46.506 1 28.772  ? 472  LEU A CA  1 
ATOM   3736 C  C   . LEU A 1 454 ? -29.198 39.773 46.809 1 28.314  ? 472  LEU A C   1 
ATOM   3737 O  O   . LEU A 1 454 ? -29.858 39.211 45.945 1 30.08   ? 472  LEU A O   1 
ATOM   3738 C  CB  . LEU A 1 454 ? -27.078 40.874 46.103 1 31.603  ? 472  LEU A CB  1 
ATOM   3739 C  CG  . LEU A 1 454 ? -26.419 42.021 45.341 1 32.597  ? 472  LEU A CG  1 
ATOM   3740 C  CD1 . LEU A 1 454 ? -24.923 41.785 45.163 1 34.475  ? 472  LEU A CD1 1 
ATOM   3741 C  CD2 . LEU A 1 454 ? -27.096 42.188 44.006 1 33.35   ? 472  LEU A CD2 1 
ATOM   3742 N  N   . ARG A 1 455 ? -29.004 39.258 48.027 1 30.985  ? 473  ARG A N   1 
ATOM   3743 C  CA  . ARG A 1 455 ? -29.548 37.959 48.413 1 30.431  ? 473  ARG A CA  1 
ATOM   3744 C  C   . ARG A 1 455 ? -31.078 38.029 48.424 1 29.885  ? 473  ARG A C   1 
ATOM   3745 O  O   . ARG A 1 455 ? -31.753 37.036 48.156 1 27.712  ? 473  ARG A O   1 
ATOM   3746 C  CB  . ARG A 1 455 ? -29.046 37.436 49.769 1 27.778  ? 473  ARG A CB  1 
ATOM   3747 C  CG  . ARG A 1 455 ? -27.537 37.374 49.931 1 29.307  ? 473  ARG A CG  1 
ATOM   3748 C  CD  . ARG A 1 455 ? -26.843 36.372 49.023 1 29.622  ? 473  ARG A CD  1 
ATOM   3749 N  NE  . ARG A 1 455 ? -27.275 35.014 49.37  1 28.927  ? 473  ARG A NE  1 
ATOM   3750 C  CZ  . ARG A 1 455 ? -28.182 34.335 48.675 1 31.489  ? 473  ARG A CZ  1 
ATOM   3751 N  NH1 . ARG A 1 455 ? -28.512 34.653 47.406 1 29.762  ? 473  ARG A NH1 1 
ATOM   3752 N  NH2 . ARG A 1 455 ? -28.737 33.301 49.279 1 32.749  ? 473  ARG A NH2 1 
ATOM   3753 N  N   . ASP A 1 456 ? -31.619 39.197 48.776 1 31.11   ? 474  ASP A N   1 
ATOM   3754 C  CA  . ASP A 1 456 ? -33.058 39.437 48.724 1 33.04   ? 474  ASP A CA  1 
ATOM   3755 C  C   . ASP A 1 456 ? -33.507 39.528 47.259 1 29.727  ? 474  ASP A C   1 
ATOM   3756 O  O   . ASP A 1 456 ? -34.374 38.778 46.873 1 26.975  ? 474  ASP A O   1 
ATOM   3757 C  CB  . ASP A 1 456 ? -33.434 40.64  49.589 1 35.304  ? 474  ASP A CB  1 
ATOM   3758 C  CG  . ASP A 1 456 ? -34.8   41.277 49.359 1 37.358  ? 474  ASP A CG  1 
ATOM   3759 O  OD1 . ASP A 1 456 ? -35.54  40.805 48.461 1 38.668  ? 474  ASP A OD1 1 
ATOM   3760 O  OD2 . ASP A 1 456 ? -35.103 42.263 50.069 1 37.412  ? 474  ASP A OD2 1 
ATOM   3761 N  N   . GLU A 1 457 ? -32.91  40.422 46.457 1 32.918  ? 475  GLU A N   1 
ATOM   3762 C  CA  . GLU A 1 457 ? -33.351 40.682 45.099 1 35.889  ? 475  GLU A CA  1 
ATOM   3763 C  C   . GLU A 1 457 ? -33.4   39.364 44.325 1 31.583  ? 475  GLU A C   1 
ATOM   3764 O  O   . GLU A 1 457 ? -34.394 39.075 43.681 1 32.363  ? 475  GLU A O   1 
ATOM   3765 C  CB  . GLU A 1 457 ? -32.515 41.715 44.329 1 43.625  ? 475  GLU A CB  1 
ATOM   3766 C  CG  . GLU A 1 457 ? -33.287 42.298 43.135 1 61.869  ? 475  GLU A CG  1 
ATOM   3767 C  CD  . GLU A 1 457 ? -32.615 42.654 41.794 1 80.178  ? 475  GLU A CD  1 
ATOM   3768 O  OE1 . GLU A 1 457 ? -31.613 43.427 41.834 1 79.518  ? 475  GLU A OE1 1 
ATOM   3769 O  OE2 . GLU A 1 457 ? -33.106 42.201 40.695 1 71.435  ? 475  GLU A OE2 1 
ATOM   3770 N  N   . TYR A 1 458 ? -32.34  38.549 44.391 1 30.862  ? 476  TYR A N   1 
ATOM   3771 C  CA  . TYR A 1 458 ? -32.186 37.426 43.475 1 27.119  ? 476  TYR A CA  1 
ATOM   3772 C  C   . TYR A 1 458 ? -32.761 36.142 44.053 1 25.416  ? 476  TYR A C   1 
ATOM   3773 O  O   . TYR A 1 458 ? -33.396 35.407 43.326 1 27.458  ? 476  TYR A O   1 
ATOM   3774 C  CB  . TYR A 1 458 ? -30.726 37.242 43.08  1 30.238  ? 476  TYR A CB  1 
ATOM   3775 C  CG  . TYR A 1 458 ? -30.269 38.279 42.072 1 31.904  ? 476  TYR A CG  1 
ATOM   3776 C  CD1 . TYR A 1 458 ? -29.831 39.536 42.454 1 34.17   ? 476  TYR A CD1 1 
ATOM   3777 C  CD2 . TYR A 1 458 ? -30.299 37.991 40.717 1 37.954  ? 476  TYR A CD2 1 
ATOM   3778 C  CE1 . TYR A 1 458 ? -29.464 40.482 41.506 1 34.266  ? 476  TYR A CE1 1 
ATOM   3779 C  CE2 . TYR A 1 458 ? -29.919 38.919 39.764 1 38.434  ? 476  TYR A CE2 1 
ATOM   3780 C  CZ  . TYR A 1 458 ? -29.516 40.175 40.158 1 36.848  ? 476  TYR A CZ  1 
ATOM   3781 O  OH  . TYR A 1 458 ? -29.154 41.043 39.171 1 35.942  ? 476  TYR A OH  1 
ATOM   3782 N  N   . SER A 1 459 ? -32.574 35.869 45.35  1 26.591  ? 477  SER A N   1 
ATOM   3783 C  CA  . SER A 1 459 ? -32.987 34.599 45.926 1 26.538  ? 477  SER A CA  1 
ATOM   3784 C  C   . SER A 1 459 ? -34.261 34.701 46.751 1 25.744  ? 477  SER A C   1 
ATOM   3785 O  O   . SER A 1 459 ? -34.84  33.687 47.106 1 28.134  ? 477  SER A O   1 
ATOM   3786 C  CB  . SER A 1 459 ? -31.883 34.02  46.795 1 28.15   ? 477  SER A CB  1 
ATOM   3787 O  OG  . SER A 1 459 ? -30.809 33.528 46.003 1 27.675  ? 477  SER A OG  1 
ATOM   3788 N  N   . GLY A 1 460 ? -34.624 35.9   47.193 1 29.311  ? 478  GLY A N   1 
ATOM   3789 C  CA  . GLY A 1 460 ? -35.791 36.073 48.05  1 27.55   ? 478  GLY A CA  1 
ATOM   3790 C  C   . GLY A 1 460 ? -35.661 35.347 49.38  1 25.858  ? 478  GLY A C   1 
ATOM   3791 O  O   . GLY A 1 460 ? -36.618 34.753 49.866 1 27.626  ? 478  GLY A O   1 
ATOM   3792 N  N   . ILE A 1 461 ? -34.464 35.414 49.955 1 28.215  ? 479  ILE A N   1 
ATOM   3793 C  CA  . ILE A 1 461 ? -34.217 34.924 51.299 1 26.923  ? 479  ILE A CA  1 
ATOM   3794 C  C   . ILE A 1 461 ? -33.67  36.088 52.115 1 28.349  ? 479  ILE A C   1 
ATOM   3795 O  O   . ILE A 1 461 ? -33.183 37.09  51.558 1 27.304  ? 479  ILE A O   1 
ATOM   3796 C  CB  . ILE A 1 461 ? -33.251 33.708 51.312 1 27.565  ? 479  ILE A CB  1 
ATOM   3797 C  CG1 . ILE A 1 461 ? -31.85  34.017 50.779 1 26.72   ? 479  ILE A CG1 1 
ATOM   3798 C  CG2 . ILE A 1 461 ? -33.841 32.521 50.564 1 29.56   ? 479  ILE A CG2 1 
ATOM   3799 C  CD1 . ILE A 1 461 ? -30.899 34.623 51.795 1 25.738  ? 479  ILE A CD1 1 
ATOM   3800 N  N   . GLU A 1 462 ? -33.693 35.901 53.447 1 28.576  ? 480  GLU A N   1 
ATOM   3801 C  CA  . GLU A 1 462 ? -33.146 36.892 54.355 1 29.672  ? 480  GLU A CA  1 
ATOM   3802 C  C   . GLU A 1 462 ? -32.622 36.199 55.609 1 27.741  ? 480  GLU A C   1 
ATOM   3803 O  O   . GLU A 1 462 ? -33.036 35.077 55.927 1 24.994  ? 480  GLU A O   1 
ATOM   3804 C  CB  . GLU A 1 462 ? -34.2   37.933 54.723 1 31.901  ? 480  GLU A CB  1 
ATOM   3805 C  CG  . GLU A 1 462 ? -35.36  37.371 55.556 1 35.556  ? 480  GLU A CG  1 
ATOM   3806 C  CD  . GLU A 1 462 ? -36.49  38.356 55.888 1 39.037  ? 480  GLU A CD  1 
ATOM   3807 O  OE1 . GLU A 1 462 ? -36.58  39.405 55.197 1 41.69   ? 480  GLU A OE1 1 
ATOM   3808 O  OE2 . GLU A 1 462 ? -37.276 38.102 56.836 1 36.354  ? 480  GLU A OE2 1 
ATOM   3809 N  N   . PRO A 1 463 ? -31.729 36.877 56.364 1 27.997  ? 481  PRO A N   1 
ATOM   3810 C  CA  . PRO A 1 463 ? -31.288 36.395 57.662 1 29.36   ? 481  PRO A CA  1 
ATOM   3811 C  C   . PRO A 1 463 ? -32.41  36.181 58.666 1 31.876  ? 481  PRO A C   1 
ATOM   3812 O  O   . PRO A 1 463 ? -33.477 36.797 58.582 1 33.752  ? 481  PRO A O   1 
ATOM   3813 C  CB  . PRO A 1 463 ? -30.416 37.503 58.182 1 28.568  ? 481  PRO A CB  1 
ATOM   3814 C  CG  . PRO A 1 463 ? -30.029 38.317 56.974 1 29.962  ? 481  PRO A CG  1 
ATOM   3815 C  CD  . PRO A 1 463 ? -31.14  38.179 56.01  1 31.297  ? 481  PRO A CD  1 
ATOM   3816 N  N   . PRO A 1 464 ? -32.182 35.309 59.663 1 31.263  ? 482  PRO A N   1 
ATOM   3817 C  CA  . PRO A 1 464 ? -33.181 35.042 60.692 1 32.668  ? 482  PRO A CA  1 
ATOM   3818 C  C   . PRO A 1 464 ? -33.318 36.145 61.736 1 34.798  ? 482  PRO A C   1 
ATOM   3819 O  O   . PRO A 1 464 ? -34.262 36.134 62.518 1 36.719  ? 482  PRO A O   1 
ATOM   3820 C  CB  . PRO A 1 464 ? -32.687 33.753 61.34  1 32.125  ? 482  PRO A CB  1 
ATOM   3821 C  CG  . PRO A 1 464 ? -31.18  33.813 61.121 1 31.578  ? 482  PRO A CG  1 
ATOM   3822 C  CD  . PRO A 1 464 ? -30.951 34.521 59.823 1 32.076  ? 482  PRO A CD  1 
ATOM   3823 N  N   . VAL A 1 465 ? -32.348 37.067 61.763 1 35.911  ? 483  VAL A N   1 
ATOM   3824 C  CA  . VAL A 1 465 ? -32.284 38.14  62.744 1 35.85   ? 483  VAL A CA  1 
ATOM   3825 C  C   . VAL A 1 465 ? -31.842 39.402 62.015 1 36.229  ? 483  VAL A C   1 
ATOM   3826 O  O   . VAL A 1 465 ? -31.281 39.325 60.917 1 32.085  ? 483  VAL A O   1 
ATOM   3827 C  CB  . VAL A 1 465 ? -31.305 37.803 63.883 1 34.941  ? 483  VAL A CB  1 
ATOM   3828 C  CG1 . VAL A 1 465 ? -31.649 36.476 64.54  1 39.775  ? 483  VAL A CG1 1 
ATOM   3829 C  CG2 . VAL A 1 465 ? -29.866 37.779 63.405 1 35.847  ? 483  VAL A CG2 1 
ATOM   3830 N  N   . VAL A 1 466 ? -32.049 40.549 62.665 1 32.621  ? 484  VAL A N   1 
ATOM   3831 C  CA  . VAL A 1 466 ? -31.665 41.813 62.079 1 32.757  ? 484  VAL A CA  1 
ATOM   3832 C  C   . VAL A 1 466 ? -30.144 41.944 62.117 1 33.775  ? 484  VAL A C   1 
ATOM   3833 O  O   . VAL A 1 466 ? -29.527 41.761 63.161 1 34.616  ? 484  VAL A O   1 
ATOM   3834 C  CB  . VAL A 1 466 ? -32.336 43.01  62.779 1 37.837  ? 484  VAL A CB  1 
ATOM   3835 C  CG1 . VAL A 1 466 ? -31.954 44.318 62.096 1 36.776  ? 484  VAL A CG1 1 
ATOM   3836 C  CG2 . VAL A 1 466 ? -33.854 42.85  62.819 1 38.838  ? 484  VAL A CG2 1 
ATOM   3837 N  N   . ARG A 1 467 ? -29.577 42.27  60.953 1 29.162  ? 485  ARG A N   1 
ATOM   3838 C  CA  . ARG A 1 467 ? -28.18  42.575 60.783 1 28.781  ? 485  ARG A CA  1 
ATOM   3839 C  C   . ARG A 1 467 ? -28.087 44.057 60.454 1 29.297  ? 485  ARG A C   1 
ATOM   3840 O  O   . ARG A 1 467 ? -29.083 44.711 60.178 1 31.584  ? 485  ARG A O   1 
ATOM   3841 C  CB  . ARG A 1 467 ? -27.555 41.767 59.639 1 30.61   ? 485  ARG A CB  1 
ATOM   3842 C  CG  . ARG A 1 467 ? -27.913 40.286 59.657 1 32.495  ? 485  ARG A CG  1 
ATOM   3843 C  CD  . ARG A 1 467 ? -27.346 39.52  60.846 1 33.858  ? 485  ARG A CD  1 
ATOM   3844 N  NE  . ARG A 1 467 ? -25.887 39.38  60.764 1 32.541  ? 485  ARG A NE  1 
ATOM   3845 C  CZ  . ARG A 1 467 ? -25.133 38.886 61.739 1 33.983  ? 485  ARG A CZ  1 
ATOM   3846 N  NH1 . ARG A 1 467 ? -25.689 38.639 62.907 1 30.493  ? 485  ARG A NH1 1 
ATOM   3847 N  NH2 . ARG A 1 467 ? -23.834 38.645 61.561 1 32.996  ? 485  ARG A NH2 1 
ATOM   3848 N  N   . SER A 1 468 ? -26.868 44.569 60.502 1 29.073  ? 486  SER A N   1 
ATOM   3849 C  CA  . SER A 1 468 ? -26.608 45.98  60.321 1 32.808  ? 486  SER A CA  1 
ATOM   3850 C  C   . SER A 1 468 ? -25.206 46.07  59.769 1 31.191  ? 486  SER A C   1 
ATOM   3851 O  O   . SER A 1 468 ? -24.56  45.042 59.583 1 33.238  ? 486  SER A O   1 
ATOM   3852 C  CB  . SER A 1 468 ? -26.747 46.769 61.628 1 37.74   ? 486  SER A CB  1 
ATOM   3853 O  OG  . SER A 1 468 ? -25.615 46.6   62.483 1 36.158  ? 486  SER A OG  1 
ATOM   3854 N  N   . GLU A 1 469 ? -24.733 47.296 59.584 1 34.941  ? 487  GLU A N   1 
ATOM   3855 C  CA  . GLU A 1 469 ? -23.366 47.535 59.153 1 33.87   ? 487  GLU A CA  1 
ATOM   3856 C  C   . GLU A 1 469 ? -22.377 47.273 60.289 1 34.241  ? 487  GLU A C   1 
ATOM   3857 O  O   . GLU A 1 469 ? -21.176 47.339 60.065 1 36.972  ? 487  GLU A O   1 
ATOM   3858 C  CB  . GLU A 1 469 ? -23.261 48.931 58.539 1 37.106  ? 487  GLU A CB  1 
ATOM   3859 C  CG  . GLU A 1 469 ? -24.088 49.061 57.263 1 41.186  ? 487  GLU A CG  1 
ATOM   3860 C  CD  . GLU A 1 469 ? -23.595 48.292 56.044 1 42.42   ? 487  GLU A CD  1 
ATOM   3861 O  OE1 . GLU A 1 469 ? -22.44  47.785 56.019 1 42.73   ? 487  GLU A OE1 1 
ATOM   3862 O  OE2 . GLU A 1 469 ? -24.393 48.245 55.086 1 44.129  ? 487  GLU A OE2 1 
ATOM   3863 N  N   . LYS A 1 470 ? -22.85  46.905 61.483 1 36.744  ? 488  LYS A N   1 
ATOM   3864 C  CA  . LYS A 1 470 ? -21.926 46.427 62.501 1 49.476  ? 488  LYS A CA  1 
ATOM   3865 C  C   . LYS A 1 470 ? -21.504 44.983 62.209 1 44.154  ? 488  LYS A C   1 
ATOM   3866 O  O   . LYS A 1 470 ? -20.507 44.525 62.742 1 43.643  ? 488  LYS A O   1 
ATOM   3867 C  CB  . LYS A 1 470 ? -22.497 46.545 63.921 1 61.317  ? 488  LYS A CB  1 
ATOM   3868 C  CG  . LYS A 1 470 ? -22.693 47.972 64.444 1 74.731  ? 488  LYS A CG  1 
ATOM   3869 C  CD  . LYS A 1 470 ? -23.612 47.997 65.665 1 90.091  ? 488  LYS A CD  1 
ATOM   3870 C  CE  . LYS A 1 470 ? -23.862 49.356 66.258 1 98.588  ? 488  LYS A CE  1 
ATOM   3871 N  NZ  . LYS A 1 470 ? -24.626 49.286 67.511 1 94.537  ? 488  LYS A NZ  1 
ATOM   3872 N  N   . ASP A 1 471 ? -22.282 44.252 61.406 1 40.733  ? 489  ASP A N   1 
ATOM   3873 C  CA  . ASP A 1 471 ? -21.965 42.875 61.057 1 37.421  ? 489  ASP A CA  1 
ATOM   3874 C  C   . ASP A 1 471 ? -21.32  42.886 59.681 1 33.225  ? 489  ASP A C   1 
ATOM   3875 O  O   . ASP A 1 471 ? -21.402 43.894 58.981 1 33.48   ? 489  ASP A O   1 
ATOM   3876 C  CB  . ASP A 1 471 ? -23.203 42.003 61.117 1 35.594  ? 489  ASP A CB  1 
ATOM   3877 C  CG  . ASP A 1 471 ? -24.031 42.208 62.376 1 40.623  ? 489  ASP A CG  1 
ATOM   3878 O  OD1 . ASP A 1 471 ? -23.539 41.853 63.477 1 41.761  ? 489  ASP A OD1 1 
ATOM   3879 O  OD2 . ASP A 1 471 ? -25.131 42.778 62.259 1 41.453  ? 489  ASP A OD2 1 
ATOM   3880 N  N   . PHE A 1 472 ? -20.659 41.783 59.324 1 30.466  ? 490  PHE A N   1 
ATOM   3881 C  CA  . PHE A 1 472 ? -20.11  41.645 57.989 1 30.103  ? 490  PHE A CA  1 
ATOM   3882 C  C   . PHE A 1 472 ? -20.192 40.174 57.616 1 29.336  ? 490  PHE A C   1 
ATOM   3883 O  O   . PHE A 1 472 ? -19.396 39.389 58.106 1 33.149  ? 490  PHE A O   1 
ATOM   3884 C  CB  . PHE A 1 472 ? -18.692 42.204 57.905 1 28.123  ? 490  PHE A CB  1 
ATOM   3885 C  CG  . PHE A 1 472 ? -18.196 42.286 56.472 1 30.793  ? 490  PHE A CG  1 
ATOM   3886 C  CD1 . PHE A 1 472 ? -18.823 43.112 55.547 1 31.876  ? 490  PHE A CD1 1 
ATOM   3887 C  CD2 . PHE A 1 472 ? -17.134 41.506 56.037 1 30.399  ? 490  PHE A CD2 1 
ATOM   3888 C  CE1 . PHE A 1 472 ? -18.378 43.18  54.231 1 31.041  ? 490  PHE A CE1 1 
ATOM   3889 C  CE2 . PHE A 1 472 ? -16.684 41.591 54.724 1 31.712  ? 490  PHE A CE2 1 
ATOM   3890 C  CZ  . PHE A 1 472 ? -17.321 42.406 53.819 1 30.142  ? 490  PHE A CZ  1 
ATOM   3891 N  N   . ASP A 1 473 ? -21.136 39.83  56.732 1 28.677  ? 491  ASP A N   1 
ATOM   3892 C  CA  . ASP A 1 473 ? -21.65  38.474 56.635 1 28.534  ? 491  ASP A CA  1 
ATOM   3893 C  C   . ASP A 1 473 ? -21.103 37.722 55.415 1 28.819  ? 491  ASP A C   1 
ATOM   3894 O  O   . ASP A 1 473 ? -21.115 36.499 55.404 1 29.783  ? 491  ASP A O   1 
ATOM   3895 C  CB  . ASP A 1 473 ? -23.168 38.501 56.7   1 31.02   ? 491  ASP A CB  1 
ATOM   3896 C  CG  . ASP A 1 473 ? -23.726 38.893 58.062 1 31.646  ? 491  ASP A CG  1 
ATOM   3897 O  OD1 . ASP A 1 473 ? -23.203 38.366 59.052 1 30.549  ? 491  ASP A OD1 1 
ATOM   3898 O  OD2 . ASP A 1 473 ? -24.668 39.732 58.124 1 28.216  ? 491  ASP A OD2 1 
ATOM   3899 N  N   . ALA A 1 474 ? -20.642 38.418 54.374 1 26.353  ? 492  ALA A N   1 
ATOM   3900 C  CA  . ALA A 1 474 ? -20.2   37.724 53.177 1 29.488  ? 492  ALA A CA  1 
ATOM   3901 C  C   . ALA A 1 474 ? -19.12  36.665 53.46  1 28.729  ? 492  ALA A C   1 
ATOM   3902 O  O   . ALA A 1 474 ? -19.241 35.532 52.985 1 26.056  ? 492  ALA A O   1 
ATOM   3903 C  CB  . ALA A 1 474 ? -19.776 38.737 52.132 1 30.726  ? 492  ALA A CB  1 
ATOM   3904 N  N   . PRO A 1 475 ? -18.05  36.949 54.255 1 30.792  ? 493  PRO A N   1 
ATOM   3905 C  CA  . PRO A 1 475 ? -16.985 35.977 54.465 1 28.59   ? 493  PRO A CA  1 
ATOM   3906 C  C   . PRO A 1 475 ? -17.396 34.728 55.239 1 29.026  ? 493  PRO A C   1 
ATOM   3907 O  O   . PRO A 1 475 ? -16.596 33.789 55.339 1 28.996  ? 493  PRO A O   1 
ATOM   3908 C  CB  . PRO A 1 475 ? -15.884 36.762 55.193 1 28.717  ? 493  PRO A CB  1 
ATOM   3909 C  CG  . PRO A 1 475 ? -16.26  38.217 55.052 1 27.594  ? 493  PRO A CG  1 
ATOM   3910 C  CD  . PRO A 1 475 ? -17.762 38.218 54.954 1 29.542  ? 493  PRO A CD  1 
ATOM   3911 N  N   . ALA A 1 476 ? -18.646 34.667 55.716 1 23.918  ? 494  ALA A N   1 
ATOM   3912 C  CA  . ALA A 1 476 ? -19.109 33.422 56.31  1 24.427  ? 494  ALA A CA  1 
ATOM   3913 C  C   . ALA A 1 476 ? -19.247 32.299 55.27  1 25.943  ? 494  ALA A C   1 
ATOM   3914 O  O   . ALA A 1 476 ? -19.446 31.146 55.626 1 26.409  ? 494  ALA A O   1 
ATOM   3915 C  CB  . ALA A 1 476 ? -20.383 33.645 57.083 1 24.167  ? 494  ALA A CB  1 
ATOM   3916 N  N   . LYS A 1 477 ? -19.155 32.617 53.981 1 27.33   ? 495  LYS A N   1 
ATOM   3917 C  CA  . LYS A 1 477 ? -19.074 31.599 52.949 1 27.348  ? 495  LYS A CA  1 
ATOM   3918 C  C   . LYS A 1 477 ? -17.604 31.286 52.633 1 29.81   ? 495  LYS A C   1 
ATOM   3919 O  O   . LYS A 1 477 ? -16.802 32.199 52.355 1 26.828  ? 495  LYS A O   1 
ATOM   3920 C  CB  . LYS A 1 477 ? -19.779 32.183 51.723 1 30.197  ? 495  LYS A CB  1 
ATOM   3921 C  CG  . LYS A 1 477 ? -19.833 31.259 50.515 1 29.76   ? 495  LYS A CG  1 
ATOM   3922 C  CD  . LYS A 1 477 ? -20.476 29.911 50.78  1 31.043  ? 495  LYS A CD  1 
ATOM   3923 C  CE  . LYS A 1 477 ? -20.322 28.982 49.6   1 34.077  ? 495  LYS A CE  1 
ATOM   3924 N  NZ  . LYS A 1 477 ? -20.518 27.595 50.034 1 35.299  ? 495  LYS A NZ  1 
ATOM   3925 N  N   . TYR A 1 478 ? -17.258 29.992 52.651 1 26.338  ? 496  TYR A N   1 
ATOM   3926 C  CA  . TYR A 1 478 ? -15.881 29.559 52.484 1 27.176  ? 496  TYR A CA  1 
ATOM   3927 C  C   . TYR A 1 478 ? -15.167 30.345 51.39  1 25.769  ? 496  TYR A C   1 
ATOM   3928 O  O   . TYR A 1 478 ? -14.113 30.939 51.609 1 27.079  ? 496  TYR A O   1 
ATOM   3929 C  CB  . TYR A 1 478 ? -15.758 28.066 52.139 1 28.504  ? 496  TYR A CB  1 
ATOM   3930 C  CG  . TYR A 1 478 ? -14.329 27.641 51.799 1 26.092  ? 496  TYR A CG  1 
ATOM   3931 C  CD1 . TYR A 1 478 ? -13.331 27.567 52.773 1 28.739  ? 496  TYR A CD1 1 
ATOM   3932 C  CD2 . TYR A 1 478 ? -13.963 27.38  50.486 1 26.913  ? 496  TYR A CD2 1 
ATOM   3933 C  CE1 . TYR A 1 478 ? -12.018 27.224 52.452 1 28.145  ? 496  TYR A CE1 1 
ATOM   3934 C  CE2 . TYR A 1 478 ? -12.661 27.03  50.154 1 28.76   ? 496  TYR A CE2 1 
ATOM   3935 C  CZ  . TYR A 1 478 ? -11.685 26.951 51.136 1 28.999  ? 496  TYR A CZ  1 
ATOM   3936 O  OH  . TYR A 1 478 ? -10.411 26.625 50.738 1 32.863  ? 496  TYR A OH  1 
ATOM   3937 N  N   . HIS A 1 479 ? -15.733 30.301 50.186 1 25.919  ? 497  HIS A N   1 
ATOM   3938 C  CA  . HIS A 1 479 ? -15.084 30.823 49.004 1 24.753  ? 497  HIS A CA  1 
ATOM   3939 C  C   . HIS A 1 479 ? -14.815 32.318 49.095 1 25.374  ? 497  HIS A C   1 
ATOM   3940 O  O   . HIS A 1 479 ? -13.963 32.844 48.39  1 28.762  ? 497  HIS A O   1 
ATOM   3941 C  CB  . HIS A 1 479 ? -15.98  30.604 47.79  1 26.364  ? 497  HIS A CB  1 
ATOM   3942 C  CG  . HIS A 1 479 ? -16.22  29.17  47.53  1 28.895  ? 497  HIS A CG  1 
ATOM   3943 N  ND1 . HIS A 1 479 ? -16.978 28.391 48.375 1 29.071  ? 497  HIS A ND1 1 
ATOM   3944 C  CD2 . HIS A 1 479 ? -15.757 28.358 46.566 1 31.814  ? 497  HIS A CD2 1 
ATOM   3945 C  CE1 . HIS A 1 479 ? -17.012 27.161 47.9   1 28.84   ? 497  HIS A CE1 1 
ATOM   3946 N  NE2 . HIS A 1 479 ? -16.3   27.126 46.786 1 31.168  ? 497  HIS A NE2 1 
ATOM   3947 N  N   . ILE A 1 480 ? -15.61  33.033 49.872 1 24.845  ? 498  ILE A N   1 
ATOM   3948 C  CA  . ILE A 1 480 ? -15.381 34.452 50.009 1 24.99   ? 498  ILE A CA  1 
ATOM   3949 C  C   . ILE A 1 480 ? -14.195 34.679 50.937 1 26.463  ? 498  ILE A C   1 
ATOM   3950 O  O   . ILE A 1 480 ? -13.365 35.544 50.654 1 27.235  ? 498  ILE A O   1 
ATOM   3951 C  CB  . ILE A 1 480 ? -16.702 35.15  50.398 1 28.097  ? 498  ILE A CB  1 
ATOM   3952 C  CG1 . ILE A 1 480 ? -17.656 35.095 49.181 1 29.768  ? 498  ILE A CG1 1 
ATOM   3953 C  CG2 . ILE A 1 480 ? -16.466 36.584 50.859 1 28.669  ? 498  ILE A CG2 1 
ATOM   3954 C  CD1 . ILE A 1 480 ? -18.957 35.834 49.362 1 38.072  ? 498  ILE A CD1 1 
ATOM   3955 N  N   . SER A 1 481 ? -14.079 33.867 51.999 1 27.487  ? 499  SER A N   1 
ATOM   3956 C  CA  . SER A 1 481 ? -12.929 33.939 52.888 1 29.137  ? 499  SER A CA  1 
ATOM   3957 C  C   . SER A 1 481 ? -11.634 33.504 52.197 1 31.718  ? 499  SER A C   1 
ATOM   3958 O  O   . SER A 1 481 ? -10.567 34.027 52.52  1 35.662  ? 499  SER A O   1 
ATOM   3959 C  CB  . SER A 1 481 ? -13.145 33.142 54.14  1 29.928  ? 499  SER A CB  1 
ATOM   3960 O  OG  . SER A 1 481 ? -13.765 33.932 55.151 1 29.636  ? 499  SER A OG  1 
ATOM   3961 N  N   . ALA A 1 482 ? -11.728 32.555 51.257 1 29.988  ? 500  ALA A N   1 
ATOM   3962 C  CA  . ALA A 1 482 ? -10.568 31.911 50.651 1 28.885  ? 500  ALA A CA  1 
ATOM   3963 C  C   . ALA A 1 482 ? -10.271 32.441 49.253 1 30.722  ? 500  ALA A C   1 
ATOM   3964 O  O   . ALA A 1 482 ? -9.358  31.956 48.577 1 31.858  ? 500  ALA A O   1 
ATOM   3965 C  CB  . ALA A 1 482 ? -10.834 30.427 50.573 1 32.767  ? 500  ALA A CB  1 
ATOM   3966 N  N   . ASP A 1 483 ? -11.073 33.396 48.78  1 31.169  ? 501  ASP A N   1 
ATOM   3967 C  CA  . ASP A 1 483 ? -10.767 34.09  47.534 1 33.229  ? 501  ASP A CA  1 
ATOM   3968 C  C   . ASP A 1 483 ? -10.796 33.126 46.341 1 30.382  ? 501  ASP A C   1 
ATOM   3969 O  O   . ASP A 1 483 ? -9.882  33.106 45.503 1 30.506  ? 501  ASP A O   1 
ATOM   3970 C  CB  . ASP A 1 483 ? -9.461  34.866 47.663 1 34.649  ? 501  ASP A CB  1 
ATOM   3971 C  CG  . ASP A 1 483 ? -9.068  35.636 46.41  1 37.696  ? 501  ASP A CG  1 
ATOM   3972 O  OD1 . ASP A 1 483 ? -10.003 36.188 45.764 1 34.333  ? 501  ASP A OD1 1 
ATOM   3973 O  OD2 . ASP A 1 483 ? -7.843  35.668 46.102 1 36.066  ? 501  ASP A OD2 1 
ATOM   3974 N  N   . VAL A 1 484 ? -11.909 32.39  46.251 1 28.774  ? 502  VAL A N   1 
ATOM   3975 C  CA  . VAL A 1 484 ? -12.197 31.494 45.15  1 28.06   ? 502  VAL A CA  1 
ATOM   3976 C  C   . VAL A 1 484 ? -13.348 32.108 44.368 1 28.495  ? 502  VAL A C   1 
ATOM   3977 O  O   . VAL A 1 484 ? -14.417 32.297 44.929 1 27.392  ? 502  VAL A O   1 
ATOM   3978 C  CB  . VAL A 1 484 ? -12.55  30.083 45.663 1 28.719  ? 502  VAL A CB  1 
ATOM   3979 C  CG1 . VAL A 1 484 ? -12.741 29.102 44.529 1 29.461  ? 502  VAL A CG1 1 
ATOM   3980 C  CG2 . VAL A 1 484 ? -11.5   29.528 46.601 1 27.967  ? 502  VAL A CG2 1 
ATOM   3981 N  N   . GLU A 1 485 ? -13.099 32.463 43.098 1 31.774  ? 503  GLU A N   1 
ATOM   3982 C  CA  . GLU A 1 485 ? -14.135 32.931 42.183 1 30.984  ? 503  GLU A CA  1 
ATOM   3983 C  C   . GLU A 1 485 ? -15.29  31.926 42.221 1 29.375  ? 503  GLU A C   1 
ATOM   3984 O  O   . GLU A 1 485 ? -15.059 30.725 42.367 1 29.815  ? 503  GLU A O   1 
ATOM   3985 C  CB  . GLU A 1 485 ? -13.439 33.138 40.835 1 34.145  ? 503  GLU A CB  1 
ATOM   3986 C  CG  . GLU A 1 485 ? -14.295 33.696 39.697 1 36.491  ? 503  GLU A CG  1 
ATOM   3987 C  CD  . GLU A 1 485 ? -14.945 32.643 38.804 1 41.095  ? 503  GLU A CD  1 
ATOM   3988 O  OE1 . GLU A 1 485 ? -15.045 31.48  39.293 1 37.791  ? 503  GLU A OE1 1 
ATOM   3989 O  OE2 . GLU A 1 485 ? -15.345 32.965 37.635 1 34.364  ? 503  GLU A OE2 1 
ATOM   3990 N  N   . TYR A 1 486 ? -16.526 32.431 42.178 1 25.966  ? 504  TYR A N   1 
ATOM   3991 C  CA  . TYR A 1 486 ? -17.71  31.601 42.335 1 25.659  ? 504  TYR A CA  1 
ATOM   3992 C  C   . TYR A 1 486 ? -18.524 31.483 41.043 1 26.954  ? 504  TYR A C   1 
ATOM   3993 O  O   . TYR A 1 486 ? -19.369 30.593 40.945 1 30.368  ? 504  TYR A O   1 
ATOM   3994 C  CB  . TYR A 1 486 ? -18.649 32.116 43.423 1 24.855  ? 504  TYR A CB  1 
ATOM   3995 C  CG  . TYR A 1 486 ? -19.366 30.998 44.155 1 24.424  ? 504  TYR A CG  1 
ATOM   3996 C  CD1 . TYR A 1 486 ? -18.734 30.306 45.184 1 24.707  ? 504  TYR A CD1 1 
ATOM   3997 C  CD2 . TYR A 1 486 ? -20.66  30.64  43.82  1 23.874  ? 504  TYR A CD2 1 
ATOM   3998 C  CE1 . TYR A 1 486 ? -19.371 29.277 45.848 1 26.066  ? 504  TYR A CE1 1 
ATOM   3999 C  CE2 . TYR A 1 486 ? -21.318 29.639 44.51  1 25.111  ? 504  TYR A CE2 1 
ATOM   4000 C  CZ  . TYR A 1 486 ? -20.67  28.951 45.519 1 25.458  ? 504  TYR A CZ  1 
ATOM   4001 O  OH  . TYR A 1 486 ? -21.315 27.931 46.161 1 26.919  ? 504  TYR A OH  1 
ATOM   4002 N  N   . LEU A 1 487 ? -18.29  32.363 40.062 1 26.229  ? 505  LEU A N   1 
ATOM   4003 C  CA  . LEU A 1 487 ? -19.002 32.277 38.794 1 29.197  ? 505  LEU A CA  1 
ATOM   4004 C  C   . LEU A 1 487 ? -18.834 30.887 38.178 1 28.647  ? 505  LEU A C   1 
ATOM   4005 O  O   . LEU A 1 487 ? -19.723 30.391 37.503 1 33.344  ? 505  LEU A O   1 
ATOM   4006 C  CB  . LEU A 1 487 ? -18.539 33.348 37.804 1 29.574  ? 505  LEU A CB  1 
ATOM   4007 C  CG  . LEU A 1 487 ? -19.578 33.736 36.749 1 30.354  ? 505  LEU A CG  1 
ATOM   4008 C  CD1 . LEU A 1 487 ? -20.695 34.507 37.431 1 30.667  ? 505  LEU A CD1 1 
ATOM   4009 C  CD2 . LEU A 1 487 ? -18.957 34.529 35.601 1 30.83   ? 505  LEU A CD2 1 
ATOM   4010 N  N   . ARG A 1 488 ? -17.669 30.273 38.369 1 29.515  ? 506  ARG A N   1 
ATOM   4011 C  CA  . ARG A 1 488 ? -17.4   28.951 37.834 1 28.679  ? 506  ARG A CA  1 
ATOM   4012 C  C   . ARG A 1 488 ? -18.564 28.01  38.159 1 29.906  ? 506  ARG A C   1 
ATOM   4013 O  O   . ARG A 1 488 ? -18.891 27.158 37.339 1 29.797  ? 506  ARG A O   1 
ATOM   4014 C  CB  . ARG A 1 488 ? -16.061 28.442 38.385 1 28.328  ? 506  ARG A CB  1 
ATOM   4015 C  CG  . ARG A 1 488 ? -16.129 28.294 39.899 1 31.396  ? 506  ARG A CG  1 
ATOM   4016 C  CD  . ARG A 1 488 ? -14.793 27.99  40.552 1 32.454  ? 506  ARG A CD  1 
ATOM   4017 N  NE  . ARG A 1 488 ? -13.774 28.955 40.144 1 31.904  ? 506  ARG A NE  1 
ATOM   4018 C  CZ  . ARG A 1 488 ? -12.487 28.793 40.378 1 33.839  ? 506  ARG A CZ  1 
ATOM   4019 N  NH1 . ARG A 1 488 ? -12.062 27.721 41.025 1 29.34   ? 506  ARG A NH1 1 
ATOM   4020 N  NH2 . ARG A 1 488 ? -11.634 29.7   39.93  1 34.808  ? 506  ARG A NH2 1 
ATOM   4021 N  N   . TYR A 1 489 ? -19.185 28.161 39.342 1 27.124  ? 507  TYR A N   1 
ATOM   4022 C  CA  . TYR A 1 489 ? -20.243 27.253 39.754 1 27.817  ? 507  TYR A CA  1 
ATOM   4023 C  C   . TYR A 1 489 ? -21.559 27.615 39.062 1 27.628  ? 507  TYR A C   1 
ATOM   4024 O  O   . TYR A 1 489 ? -22.342 26.729 38.744 1 26.796  ? 507  TYR A O   1 
ATOM   4025 C  CB  . TYR A 1 489 ? -20.446 27.192 41.274 1 28.414  ? 507  TYR A CB  1 
ATOM   4026 C  CG  . TYR A 1 489 ? -19.208 26.75  42.032 1 33.585  ? 507  TYR A CG  1 
ATOM   4027 C  CD1 . TYR A 1 489 ? -18.813 25.423 42.043 1 36.897  ? 507  TYR A CD1 1 
ATOM   4028 C  CD2 . TYR A 1 489 ? -18.434 27.655 42.747 1 38.168  ? 507  TYR A CD2 1 
ATOM   4029 C  CE1 . TYR A 1 489 ? -17.681 25.005 42.718 1 39.59   ? 507  TYR A CE1 1 
ATOM   4030 C  CE2 . TYR A 1 489 ? -17.304 27.242 43.434 1 42.791  ? 507  TYR A CE2 1 
ATOM   4031 C  CZ  . TYR A 1 489 ? -16.917 25.916 43.417 1 41.576  ? 507  TYR A CZ  1 
ATOM   4032 O  OH  . TYR A 1 489 ? -15.8   25.488 44.086 1 51.723  ? 507  TYR A OH  1 
ATOM   4033 N  N   . LEU A 1 490 ? -21.825 28.908 38.838 1 27.493  ? 508  LEU A N   1 
ATOM   4034 C  CA  . LEU A 1 490 ? -22.941 29.296 37.99  1 27.95   ? 508  LEU A CA  1 
ATOM   4035 C  C   . LEU A 1 490 ? -22.771 28.695 36.591 1 26.444  ? 508  LEU A C   1 
ATOM   4036 O  O   . LEU A 1 490 ? -23.684 28.059 36.043 1 28.792  ? 508  LEU A O   1 
ATOM   4037 C  CB  . LEU A 1 490 ? -23.054 30.816 37.942 1 29.934  ? 508  LEU A CB  1 
ATOM   4038 C  CG  . LEU A 1 490 ? -24.158 31.381 37.048 1 30.873  ? 508  LEU A CG  1 
ATOM   4039 C  CD1 . LEU A 1 490 ? -25.495 30.812 37.433 1 34.195  ? 508  LEU A CD1 1 
ATOM   4040 C  CD2 . LEU A 1 490 ? -24.183 32.881 37.156 1 32.808  ? 508  LEU A CD2 1 
ATOM   4041 N  N   . VAL A 1 491 ? -21.592 28.871 36.001 1 24.547  ? 509  VAL A N   1 
ATOM   4042 C  CA  . VAL A 1 491 ? -21.392 28.343 34.66  1 27.413  ? 509  VAL A CA  1 
ATOM   4043 C  C   . VAL A 1 491 ? -21.597 26.815 34.7   1 29.509  ? 509  VAL A C   1 
ATOM   4044 O  O   . VAL A 1 491 ? -22.269 26.237 33.867 1 29.501  ? 509  VAL A O   1 
ATOM   4045 C  CB  . VAL A 1 491 ? -20.022 28.766 34.103 1 26.209  ? 509  VAL A CB  1 
ATOM   4046 C  CG1 . VAL A 1 491 ? -19.682 28.112 32.765 1 27.486  ? 509  VAL A CG1 1 
ATOM   4047 C  CG2 . VAL A 1 491 ? -19.947 30.277 33.947 1 29.159  ? 509  VAL A CG2 1 
ATOM   4048 N  N   . SER A 1 492 ? -21.082 26.157 35.73  1 31.187  ? 510  SER A N   1 
ATOM   4049 C  CA  . SER A 1 492 ? -21.134 24.711 35.808 1 30.867  ? 510  SER A CA  1 
ATOM   4050 C  C   . SER A 1 492 ? -22.583 24.237 35.828 1 29.966  ? 510  SER A C   1 
ATOM   4051 O  O   . SER A 1 492 ? -22.93  23.325 35.1   1 28.032  ? 510  SER A O   1 
ATOM   4052 C  CB  . SER A 1 492 ? -20.39  24.229 37.013 1 31.172  ? 510  SER A CB  1 
ATOM   4053 O  OG  . SER A 1 492 ? -20.793 22.911 37.344 1 40.332  ? 510  SER A OG  1 
ATOM   4054 N  N   . PHE A 1 493 ? -23.426 24.842 36.667 1 30.662  ? 511  PHE A N   1 
ATOM   4055 C  CA  . PHE A 1 493 ? -24.799 24.377 36.832 1 28.445  ? 511  PHE A CA  1 
ATOM   4056 C  C   . PHE A 1 493 ? -25.609 24.581 35.553 1 29.297  ? 511  PHE A C   1 
ATOM   4057 O  O   . PHE A 1 493 ? -26.538 23.851 35.298 1 33.545  ? 511  PHE A O   1 
ATOM   4058 C  CB  . PHE A 1 493 ? -25.496 25.017 38.03  1 27.694  ? 511  PHE A CB  1 
ATOM   4059 C  CG  . PHE A 1 493 ? -25.13  24.357 39.352 1 27.382  ? 511  PHE A CG  1 
ATOM   4060 C  CD1 . PHE A 1 493 ? -23.816 24.018 39.641 1 30.729  ? 511  PHE A CD1 1 
ATOM   4061 C  CD2 . PHE A 1 493 ? -26.116 23.988 40.252 1 28.871  ? 511  PHE A CD2 1 
ATOM   4062 C  CE1 . PHE A 1 493 ? -23.489 23.407 40.847 1 32.893  ? 511  PHE A CE1 1 
ATOM   4063 C  CE2 . PHE A 1 493 ? -25.798 23.392 41.46  1 33.158  ? 511  PHE A CE2 1 
ATOM   4064 C  CZ  . PHE A 1 493 ? -24.481 23.088 41.757 1 33.77   ? 511  PHE A CZ  1 
ATOM   4065 N  N   . ILE A 1 494 ? -25.23  25.496 34.681 1 31.916  ? 512  ILE A N   1 
ATOM   4066 C  CA  . ILE A 1 494 ? -25.863 25.553 33.376 1 31.238  ? 512  ILE A CA  1 
ATOM   4067 C  C   . ILE A 1 494 ? -25.261 24.516 32.418 1 32.702  ? 512  ILE A C   1 
ATOM   4068 O  O   . ILE A 1 494 ? -26.023 23.767 31.792 1 29.096  ? 512  ILE A O   1 
ATOM   4069 C  CB  . ILE A 1 494 ? -25.72  26.975 32.836 1 33.589  ? 512  ILE A CB  1 
ATOM   4070 C  CG1 . ILE A 1 494 ? -26.564 27.921 33.671 1 35.784  ? 512  ILE A CG1 1 
ATOM   4071 C  CG2 . ILE A 1 494 ? -26.047 27.048 31.346 1 35.323  ? 512  ILE A CG2 1 
ATOM   4072 C  CD1 . ILE A 1 494 ? -26.084 29.355 33.581 1 37.81   ? 512  ILE A CD1 1 
ATOM   4073 N  N   . ILE A 1 495 ? -23.914 24.475 32.285 1 29.705  ? 513  ILE A N   1 
ATOM   4074 C  CA  . ILE A 1 495 ? -23.323 23.717 31.192 1 33.794  ? 513  ILE A CA  1 
ATOM   4075 C  C   . ILE A 1 495 ? -23.383 22.22  31.474 1 32.472  ? 513  ILE A C   1 
ATOM   4076 O  O   . ILE A 1 495 ? -23.416 21.435 30.543 1 32.29   ? 513  ILE A O   1 
ATOM   4077 C  CB  . ILE A 1 495 ? -21.886 24.1   30.812 1 34.993  ? 513  ILE A CB  1 
ATOM   4078 C  CG1 . ILE A 1 495 ? -20.954 23.977 31.99  1 35.107  ? 513  ILE A CG1 1 
ATOM   4079 C  CG2 . ILE A 1 495 ? -21.826 25.471 30.145 1 36.89   ? 513  ILE A CG2 1 
ATOM   4080 C  CD1 . ILE A 1 495 ? -19.51  24.157 31.594 1 36.279  ? 513  ILE A CD1 1 
ATOM   4081 N  N   . GLN A 1 496 ? -23.368 21.819 32.735 1 28.452  ? 514  GLN A N   1 
ATOM   4082 C  CA  . GLN A 1 496 ? -23.416 20.408 33.048 1 29.023  ? 514  GLN A CA  1 
ATOM   4083 C  C   . GLN A 1 496 ? -24.678 19.755 32.49  1 31.027  ? 514  GLN A C   1 
ATOM   4084 O  O   . GLN A 1 496 ? -24.697 18.543 32.325 1 32.803  ? 514  GLN A O   1 
ATOM   4085 C  CB  . GLN A 1 496 ? -23.34  20.166 34.551 1 29.941  ? 514  GLN A CB  1 
ATOM   4086 C  CG  . GLN A 1 496 ? -24.581 20.606 35.311 1 32.568  ? 514  GLN A CG  1 
ATOM   4087 C  CD  . GLN A 1 496 ? -24.411 20.471 36.812 1 36.308  ? 514  GLN A CD  1 
ATOM   4088 O  OE1 . GLN A 1 496 ? -25.152 19.735 37.469 1 34.468  ? 514  GLN A OE1 1 
ATOM   4089 N  NE2 . GLN A 1 496 ? -23.382 21.113 37.359 1 36.772  ? 514  GLN A NE2 1 
ATOM   4090 N  N   . PHE A 1 497 ? -25.746 20.525 32.278 1 28.824  ? 515  PHE A N   1 
ATOM   4091 C  CA  . PHE A 1 497 ? -26.965 19.989 31.692 1 31.305  ? 515  PHE A CA  1 
ATOM   4092 C  C   . PHE A 1 497 ? -26.769 19.827 30.184 1 32.49   ? 515  PHE A C   1 
ATOM   4093 O  O   . PHE A 1 497 ? -27.368 18.95  29.58  1 34.586  ? 515  PHE A O   1 
ATOM   4094 C  CB  . PHE A 1 497 ? -28.222 20.817 32.018 1 28.084  ? 515  PHE A CB  1 
ATOM   4095 C  CG  . PHE A 1 497 ? -28.695 20.534 33.435 1 27.808  ? 515  PHE A CG  1 
ATOM   4096 C  CD1 . PHE A 1 497 ? -28.182 21.236 34.515 1 31.205  ? 515  PHE A CD1 1 
ATOM   4097 C  CD2 . PHE A 1 497 ? -29.605 19.531 33.706 1 28.287  ? 515  PHE A CD2 1 
ATOM   4098 C  CE1 . PHE A 1 497 ? -28.593 20.97  35.818 1 30.266  ? 515  PHE A CE1 1 
ATOM   4099 C  CE2 . PHE A 1 497 ? -29.999 19.253 35.008 1 31.333  ? 515  PHE A CE2 1 
ATOM   4100 C  CZ  . PHE A 1 497 ? -29.475 19.96  36.062 1 30.393  ? 515  PHE A CZ  1 
ATOM   4101 N  N   . GLN A 1 498 ? -25.951 20.671 29.564 1 33.946  ? 516  GLN A N   1 
ATOM   4102 C  CA  . GLN A 1 498 ? -25.624 20.483 28.157 1 33.432  ? 516  GLN A CA  1 
ATOM   4103 C  C   . GLN A 1 498 ? -24.792 19.207 27.974 1 36.886  ? 516  GLN A C   1 
ATOM   4104 O  O   . GLN A 1 498 ? -24.995 18.449 27.027 1 38.5    ? 516  GLN A O   1 
ATOM   4105 C  CB  . GLN A 1 498 ? -24.853 21.664 27.577 1 33.756  ? 516  GLN A CB  1 
ATOM   4106 C  CG  . GLN A 1 498 ? -25.565 23.006 27.718 1 34.226  ? 516  GLN A CG  1 
ATOM   4107 C  CD  . GLN A 1 498 ? -24.846 24.135 27.02  1 34.432  ? 516  GLN A CD  1 
ATOM   4108 O  OE1 . GLN A 1 498 ? -24.522 25.16  27.619 1 40.222  ? 516  GLN A OE1 1 
ATOM   4109 N  NE2 . GLN A 1 498 ? -24.604 23.975 25.731 1 36.795  ? 516  GLN A NE2 1 
ATOM   4110 N  N   . PHE A 1 499 ? -23.828 18.987 28.865 1 34.887  ? 517  PHE A N   1 
ATOM   4111 C  CA  . PHE A 1 499 ? -23     17.808 28.794 1 34.836  ? 517  PHE A CA  1 
ATOM   4112 C  C   . PHE A 1 499 ? -23.839 16.57  29.065 1 36.359  ? 517  PHE A C   1 
ATOM   4113 O  O   . PHE A 1 499 ? -23.666 15.582 28.372 1 39.895  ? 517  PHE A O   1 
ATOM   4114 C  CB  . PHE A 1 499 ? -21.89  17.873 29.837 1 36.645  ? 517  PHE A CB  1 
ATOM   4115 C  CG  . PHE A 1 499 ? -20.844 18.947 29.615 1 35.099  ? 517  PHE A CG  1 
ATOM   4116 C  CD1 . PHE A 1 499 ? -20.511 19.374 28.339 1 35.729  ? 517  PHE A CD1 1 
ATOM   4117 C  CD2 . PHE A 1 499 ? -20.171 19.488 30.694 1 35.064  ? 517  PHE A CD2 1 
ATOM   4118 C  CE1 . PHE A 1 499 ? -19.531 20.331 28.149 1 35.573  ? 517  PHE A CE1 1 
ATOM   4119 C  CE2 . PHE A 1 499 ? -19.194 20.446 30.501 1 38.36   ? 517  PHE A CE2 1 
ATOM   4120 C  CZ  . PHE A 1 499 ? -18.883 20.872 29.227 1 37.345  ? 517  PHE A CZ  1 
ATOM   4121 N  N   . TYR A 1 500 ? -24.69  16.611 30.099 1 33.781  ? 518  TYR A N   1 
ATOM   4122 C  CA  . TYR A 1 500 ? -25.465 15.448 30.502 1 33.795  ? 518  TYR A CA  1 
ATOM   4123 C  C   . TYR A 1 500 ? -26.454 15.077 29.397 1 34.131  ? 518  TYR A C   1 
ATOM   4124 O  O   . TYR A 1 500 ? -26.58  13.928 29.016 1 34.29   ? 518  TYR A O   1 
ATOM   4125 C  CB  . TYR A 1 500 ? -26.185 15.723 31.817 1 32.955  ? 518  TYR A CB  1 
ATOM   4126 C  CG  . TYR A 1 500 ? -27.05  14.608 32.399 1 33.024  ? 518  TYR A CG  1 
ATOM   4127 C  CD1 . TYR A 1 500 ? -26.476 13.481 32.976 1 33.77   ? 518  TYR A CD1 1 
ATOM   4128 C  CD2 . TYR A 1 500 ? -28.437 14.709 32.419 1 33.232  ? 518  TYR A CD2 1 
ATOM   4129 C  CE1 . TYR A 1 500 ? -27.247 12.48  33.539 1 35.416  ? 518  TYR A CE1 1 
ATOM   4130 C  CE2 . TYR A 1 500 ? -29.222 13.706 32.966 1 36.799  ? 518  TYR A CE2 1 
ATOM   4131 C  CZ  . TYR A 1 500 ? -28.623 12.6   33.545 1 35.267  ? 518  TYR A CZ  1 
ATOM   4132 O  OH  . TYR A 1 500 ? -29.364 11.65  34.157 1 38.76   ? 518  TYR A OH  1 
ATOM   4133 N  N   . LYS A 1 501 ? -27.167 16.049 28.859 1 35.025  ? 519  LYS A N   1 
ATOM   4134 C  CA  . LYS A 1 501 ? -28.099 15.734 27.797 1 39.819  ? 519  LYS A CA  1 
ATOM   4135 C  C   . LYS A 1 501 ? -27.37  15.021 26.66  1 38.167  ? 519  LYS A C   1 
ATOM   4136 O  O   . LYS A 1 501 ? -27.832 13.999 26.172 1 37.845  ? 519  LYS A O   1 
ATOM   4137 C  CB  . LYS A 1 501 ? -28.795 17.004 27.316 1 40.181  ? 519  LYS A CB  1 
ATOM   4138 C  CG  . LYS A 1 501 ? -29.693 16.837 26.127 1 42.021  ? 519  LYS A CG  1 
ATOM   4139 C  CD  . LYS A 1 501 ? -30.298 18.157 25.683 1 46.873  ? 519  LYS A CD  1 
ATOM   4140 C  CE  . LYS A 1 501 ? -30.804 17.975 24.299 1 51.617  ? 519  LYS A CE  1 
ATOM   4141 N  NZ  . LYS A 1 501 ? -31.412 19.184 23.755 1 51.796  ? 519  LYS A NZ  1 
ATOM   4142 N  N   . SER A 1 502 ? -26.248 15.582 26.231 1 36.008  ? 520  SER A N   1 
ATOM   4143 C  CA  . SER A 1 502 ? -25.485 15.017 25.134 1 40.155  ? 520  SER A CA  1 
ATOM   4144 C  C   . SER A 1 502 ? -24.896 13.65  25.482 1 38.614  ? 520  SER A C   1 
ATOM   4145 O  O   . SER A 1 502 ? -24.908 12.78  24.638 1 40.496  ? 520  SER A O   1 
ATOM   4146 C  CB  . SER A 1 502 ? -24.421 15.967 24.673 1 41.535  ? 520  SER A CB  1 
ATOM   4147 O  OG  . SER A 1 502 ? -25.015 16.88  23.761 1 45.162  ? 520  SER A OG  1 
ATOM   4148 N  N   . ALA A 1 503 ? -24.361 13.47  26.694 1 36.285  ? 521  ALA A N   1 
ATOM   4149 C  CA  . ALA A 1 503 ? -23.862 12.187 27.152 1 36.841  ? 521  ALA A CA  1 
ATOM   4150 C  C   . ALA A 1 503 ? -24.967 11.124 27.12  1 43.618  ? 521  ALA A C   1 
ATOM   4151 O  O   . ALA A 1 503 ? -24.723 9.985  26.719 1 40.122  ? 521  ALA A O   1 
ATOM   4152 C  CB  . ALA A 1 503 ? -23.31  12.312 28.547 1 34.941  ? 521  ALA A CB  1 
ATOM   4153 N  N   . CYS A 1 504 ? -26.163 11.518 27.571 1 41.52   ? 522  CYS A N   1 
ATOM   4154 C  CA  . CYS A 1 504 ? -27.333 10.66  27.619 1 43.632  ? 522  CYS A CA  1 
ATOM   4155 C  C   . CYS A 1 504 ? -27.77  10.244 26.207 1 44.576  ? 522  CYS A C   1 
ATOM   4156 O  O   . CYS A 1 504 ? -28.109 9.089  25.981 1 43.018  ? 522  CYS A O   1 
ATOM   4157 C  CB  . CYS A 1 504 ? -28.453 11.328 28.417 1 41.097  ? 522  CYS A CB  1 
ATOM   4158 S  SG  . CYS A 1 504 ? -28.049 11.506 30.178 1 40.358  ? 522  CYS A SG  1 
ATOM   4159 N  N   . ILE A 1 505 ? -27.766 11.164 25.245 1 42.227  ? 523  ILE A N   1 
ATOM   4160 C  CA  . ILE A 1 505 ? -28.132 10.808 23.884 1 43.338  ? 523  ILE A CA  1 
ATOM   4161 C  C   . ILE A 1 505 ? -27.123 9.795  23.338 1 46.717  ? 523  ILE A C   1 
ATOM   4162 O  O   . ILE A 1 505 ? -27.505 8.775  22.767 1 41.717  ? 523  ILE A O   1 
ATOM   4163 C  CB  . ILE A 1 505 ? -28.212 12.058 23.005 1 44.687  ? 523  ILE A CB  1 
ATOM   4164 C  CG1 . ILE A 1 505 ? -29.453 12.886 23.336 1 45.629  ? 523  ILE A CG1 1 
ATOM   4165 C  CG2 . ILE A 1 505 ? -28.137 11.679 21.527 1 45.423  ? 523  ILE A CG2 1 
ATOM   4166 C  CD1 . ILE A 1 505 ? -29.498 14.247 22.638 1 49.61   ? 523  ILE A CD1 1 
ATOM   4167 N  N   . LYS A 1 506 ? -25.834 10.078 23.558 1 44.769  ? 524  LYS A N   1 
ATOM   4168 C  CA  . LYS A 1 506 ? -24.755 9.227  23.086 1 46.753  ? 524  LYS A CA  1 
ATOM   4169 C  C   . LYS A 1 506 ? -24.831 7.834  23.699 1 45.802  ? 524  LYS A C   1 
ATOM   4170 O  O   . LYS A 1 506 ? -24.307 6.893  23.119 1 47.917  ? 524  LYS A O   1 
ATOM   4171 C  CB  . LYS A 1 506 ? -23.374 9.787  23.447 1 44.184  ? 524  LYS A CB  1 
ATOM   4172 C  CG  . LYS A 1 506 ? -22.987 11.03  22.676 1 43.771  ? 524  LYS A CG  1 
ATOM   4173 C  CD  . LYS A 1 506 ? -21.685 11.618 23.203 1 45.381  ? 524  LYS A CD  1 
ATOM   4174 C  CE  . LYS A 1 506 ? -21.527 13.044 22.772 1 48.041  ? 524  LYS A CE  1 
ATOM   4175 N  NZ  . LYS A 1 506 ? -21.367 13.182 21.323 1 45.36   ? 524  LYS A NZ  1 
ATOM   4176 N  N   . ALA A 1 507 ? -25.415 7.727  24.896 1 45.178  ? 525  ALA A N   1 
ATOM   4177 C  CA  . ALA A 1 507 ? -25.42  6.481  25.639 1 41.948  ? 525  ALA A CA  1 
ATOM   4178 C  C   . ALA A 1 507 ? -26.687 5.681  25.342 1 41.437  ? 525  ALA A C   1 
ATOM   4179 O  O   . ALA A 1 507 ? -26.913 4.644  25.959 1 44.475  ? 525  ALA A O   1 
ATOM   4180 C  CB  . ALA A 1 507 ? -25.305 6.784  27.116 1 40.857  ? 525  ALA A CB  1 
ATOM   4181 N  N   . GLY A 1 508 ? -27.521 6.201  24.435 1 43.224  ? 526  GLY A N   1 
ATOM   4182 C  CA  . GLY A 1 508 ? -28.83  5.64   24.147 1 45.603  ? 526  GLY A CA  1 
ATOM   4183 C  C   . GLY A 1 508 ? -29.839 5.811  25.285 1 45.954  ? 526  GLY A C   1 
ATOM   4184 O  O   . GLY A 1 508 ? -30.915 5.227  25.236 1 54.954  ? 526  GLY A O   1 
ATOM   4185 N  N   . GLN A 1 509 ? -29.532 6.632  26.29  1 43.918  ? 527  GLN A N   1 
ATOM   4186 C  CA  . GLN A 1 509 ? -30.365 6.735  27.48  1 42.87   ? 527  GLN A CA  1 
ATOM   4187 C  C   . GLN A 1 509 ? -31.387 7.863  27.409 1 40.969  ? 527  GLN A C   1 
ATOM   4188 O  O   . GLN A 1 509 ? -32.17  8.018  28.339 1 44.546  ? 527  GLN A O   1 
ATOM   4189 C  CB  . GLN A 1 509 ? -29.499 7.034  28.688 1 43.516  ? 527  GLN A CB  1 
ATOM   4190 C  CG  . GLN A 1 509 ? -28.689 5.841  29.156 1 46.338  ? 527  GLN A CG  1 
ATOM   4191 C  CD  . GLN A 1 509 ? -29.511 4.925  30.024 1 48.873  ? 527  GLN A CD  1 
ATOM   4192 O  OE1 . GLN A 1 509 ? -30.115 5.357  31.01  1 54.521  ? 527  GLN A OE1 1 
ATOM   4193 N  NE2 . GLN A 1 509 ? -29.541 3.651  29.672 1 49.412  ? 527  GLN A NE2 1 
ATOM   4194 N  N   . TYR A 1 510 ? -31.408 8.634  26.319 1 39.494  ? 528  TYR A N   1 
ATOM   4195 C  CA  . TYR A 1 510 ? -32.364 9.713  26.211 1 39.352  ? 528  TYR A CA  1 
ATOM   4196 C  C   . TYR A 1 510 ? -32.83  9.849  24.77  1 43.804  ? 528  TYR A C   1 
ATOM   4197 O  O   . TYR A 1 510 ? -32.025 9.998  23.853 1 41.073  ? 528  TYR A O   1 
ATOM   4198 C  CB  . TYR A 1 510 ? -31.788 11.054 26.687 1 39.16   ? 528  TYR A CB  1 
ATOM   4199 C  CG  . TYR A 1 510 ? -32.699 12.267 26.516 1 35.986  ? 528  TYR A CG  1 
ATOM   4200 C  CD1 . TYR A 1 510 ? -34.004 12.259 26.984 1 34.13   ? 528  TYR A CD1 1 
ATOM   4201 C  CD2 . TYR A 1 510 ? -32.261 13.416 25.859 1 38.912  ? 528  TYR A CD2 1 
ATOM   4202 C  CE1 . TYR A 1 510 ? -34.844 13.348 26.808 1 37.054  ? 528  TYR A CE1 1 
ATOM   4203 C  CE2 . TYR A 1 510 ? -33.089 14.514 25.679 1 37.934  ? 528  TYR A CE2 1 
ATOM   4204 C  CZ  . TYR A 1 510 ? -34.387 14.482 26.161 1 38.251  ? 528  TYR A CZ  1 
ATOM   4205 O  OH  . TYR A 1 510 ? -35.222 15.553 26.02  1 37.746  ? 528  TYR A OH  1 
ATOM   4206 N  N   . ASP A 1 511 ? -34.156 9.863  24.628 1 49.251  ? 529  ASP A N   1 
ATOM   4207 C  CA  . ASP A 1 511 ? -34.826 10.189 23.386 1 57.134  ? 529  ASP A CA  1 
ATOM   4208 C  C   . ASP A 1 511 ? -36.023 11.033 23.793 1 58.135  ? 529  ASP A C   1 
ATOM   4209 O  O   . ASP A 1 511 ? -36.814 10.571 24.613 1 51.859  ? 529  ASP A O   1 
ATOM   4210 C  CB  . ASP A 1 511 ? -35.236 8.925  22.637 1 62.39   ? 529  ASP A CB  1 
ATOM   4211 C  CG  . ASP A 1 511 ? -35.839 9.102  21.245 1 68.282  ? 529  ASP A CG  1 
ATOM   4212 O  OD1 . ASP A 1 511 ? -36.058 10.261 20.809 1 61.781  ? 529  ASP A OD1 1 
ATOM   4213 O  OD2 . ASP A 1 511 ? -36.093 8.067  20.593 1 75.003  ? 529  ASP A OD2 1 
ATOM   4214 N  N   . PRO A 1 512 ? -36.133 12.308 23.336 1 62.701  ? 530  PRO A N   1 
ATOM   4215 C  CA  . PRO A 1 512 ? -37.296 13.13  23.659 1 67.018  ? 530  PRO A CA  1 
ATOM   4216 C  C   . PRO A 1 512 ? -38.633 12.473 23.309 1 72.53   ? 530  PRO A C   1 
ATOM   4217 O  O   . PRO A 1 512 ? -39.577 12.571 24.088 1 71.407  ? 530  PRO A O   1 
ATOM   4218 C  CB  . PRO A 1 512 ? -37.073 14.442 22.903 1 65.557  ? 530  PRO A CB  1 
ATOM   4219 C  CG  . PRO A 1 512 ? -35.86  14.211 22.026 1 65.634  ? 530  PRO A CG  1 
ATOM   4220 C  CD  . PRO A 1 512 ? -35.113 13.029 22.559 1 59.674  ? 530  PRO A CD  1 
ATOM   4221 N  N   . ASP A 1 513 ? -38.692 11.763 22.171 1 80.213  ? 531  ASP A N   1 
ATOM   4222 C  CA  . ASP A 1 513 ? -39.937 11.194 21.67  1 79.924  ? 531  ASP A CA  1 
ATOM   4223 C  C   . ASP A 1 513 ? -40.102 9.743  22.118 1 75.926  ? 531  ASP A C   1 
ATOM   4224 O  O   . ASP A 1 513 ? -40.588 8.914  21.36  1 86.724  ? 531  ASP A O   1 
ATOM   4225 C  CB  . ASP A 1 513 ? -40.004 11.314 20.156 1 81.373  ? 531  ASP A CB  1 
ATOM   4226 C  CG  . ASP A 1 513 ? -39.869 12.733 19.617 1 85.121  ? 531  ASP A CG  1 
ATOM   4227 O  OD1 . ASP A 1 513 ? -40.686 13.59  20.012 1 83.995  ? 531  ASP A OD1 1 
ATOM   4228 O  OD2 . ASP A 1 513 ? -38.948 12.976 18.809 1 74.827  ? 531  ASP A OD2 1 
ATOM   4229 N  N   . ASN A 1 514 ? -39.724 9.439  23.361 1 71.463  ? 532  ASN A N   1 
ATOM   4230 C  CA  . ASN A 1 514 ? -39.835 8.093  23.892 1 65.432  ? 532  ASN A CA  1 
ATOM   4231 C  C   . ASN A 1 514 ? -39.82  8.165  25.418 1 70.117  ? 532  ASN A C   1 
ATOM   4232 O  O   . ASN A 1 514 ? -38.774 8.428  26.028 1 64.741  ? 532  ASN A O   1 
ATOM   4233 C  CB  . ASN A 1 514 ? -38.746 7.191  23.329 1 64.751  ? 532  ASN A CB  1 
ATOM   4234 C  CG  . ASN A 1 514 ? -38.711 5.827  23.988 1 67.103  ? 532  ASN A CG  1 
ATOM   4235 O  OD1 . ASN A 1 514 ? -39.593 5.471  24.788 1 58.973  ? 532  ASN A OD1 1 
ATOM   4236 N  ND2 . ASN A 1 514 ? -37.676 5.058  23.682 1 62.889  ? 532  ASN A ND2 1 
ATOM   4237 N  N   . VAL A 1 515 ? -40.985 7.865  26.01  1 64.41   ? 533  VAL A N   1 
ATOM   4238 C  CA  . VAL A 1 515 ? -41.273 8.138  27.411 1 64.08   ? 533  VAL A CA  1 
ATOM   4239 C  C   . VAL A 1 515 ? -40.6   7.11   28.332 1 64.678  ? 533  VAL A C   1 
ATOM   4240 O  O   . VAL A 1 515 ? -40.617 7.247  29.558 1 60.145  ? 533  VAL A O   1 
ATOM   4241 C  CB  . VAL A 1 515 ? -42.807 8.177  27.581 1 71.38   ? 533  VAL A CB  1 
ATOM   4242 C  CG1 . VAL A 1 515 ? -43.497 6.965  26.955 1 69.213  ? 533  VAL A CG1 1 
ATOM   4243 C  CG2 . VAL A 1 515 ? -43.223 8.356  29.043 1 77.009  ? 533  VAL A CG2 1 
ATOM   4244 N  N   . GLU A 1 516 ? -40.009 6.069  27.735 1 62.785  ? 534  GLU A N   1 
ATOM   4245 C  CA  . GLU A 1 516 ? -39.221 5.092  28.472 1 70.955  ? 534  GLU A CA  1 
ATOM   4246 C  C   . GLU A 1 516 ? -37.831 5.647  28.791 1 56.566  ? 534  GLU A C   1 
ATOM   4247 O  O   . GLU A 1 516 ? -37.186 5.115  29.689 1 51.622  ? 534  GLU A O   1 
ATOM   4248 C  CB  . GLU A 1 516 ? -38.964 3.779  27.713 1 88.964  ? 534  GLU A CB  1 
ATOM   4249 C  CG  . GLU A 1 516 ? -40.18  3.133  27.049 1 95.115  ? 534  GLU A CG  1 
ATOM   4250 C  CD  . GLU A 1 516 ? -41.399 3.02   27.947 1 101.329 ? 534  GLU A CD  1 
ATOM   4251 O  OE1 . GLU A 1 516 ? -41.255 2.586  29.111 1 98.357  ? 534  GLU A OE1 1 
ATOM   4252 O  OE2 . GLU A 1 516 ? -42.498 3.377  27.473 1 110.621 ? 534  GLU A OE2 1 
ATOM   4253 N  N   . LEU A 1 517 ? -37.371 6.662  28.026 1 53.048  ? 535  LEU A N   1 
ATOM   4254 C  CA  . LEU A 1 517 ? -36.023 7.223  28.124 1 55.15   ? 535  LEU A CA  1 
ATOM   4255 C  C   . LEU A 1 517 ? -36.101 8.714  28.429 1 51.363  ? 535  LEU A C   1 
ATOM   4256 O  O   . LEU A 1 517 ? -35.714 9.516  27.58  1 52.476  ? 535  LEU A O   1 
ATOM   4257 C  CB  . LEU A 1 517 ? -35.252 7.062  26.815 1 60.701  ? 535  LEU A CB  1 
ATOM   4258 C  CG  . LEU A 1 517 ? -35.104 5.645  26.252 1 65.183  ? 535  LEU A CG  1 
ATOM   4259 C  CD1 . LEU A 1 517 ? -34.469 5.699  24.851 1 62.548  ? 535  LEU A CD1 1 
ATOM   4260 C  CD2 . LEU A 1 517 ? -34.315 4.767  27.221 1 60.888  ? 535  LEU A CD2 1 
ATOM   4261 N  N   . PRO A 1 518 ? -36.601 9.142  29.616 1 48.646  ? 536  PRO A N   1 
ATOM   4262 C  CA  . PRO A 1 518 ? -36.635 10.563 29.954 1 47.272  ? 536  PRO A CA  1 
ATOM   4263 C  C   . PRO A 1 518 ? -35.29  11.039 30.505 1 40.509  ? 536  PRO A C   1 
ATOM   4264 O  O   . PRO A 1 518 ? -34.547 10.267 31.111 1 40.695  ? 536  PRO A O   1 
ATOM   4265 C  CB  . PRO A 1 518 ? -37.777 10.621 30.968 1 41.926  ? 536  PRO A CB  1 
ATOM   4266 C  CG  . PRO A 1 518 ? -37.578 9.308  31.733 1 40.176  ? 536  PRO A CG  1 
ATOM   4267 C  CD  . PRO A 1 518 ? -37.122 8.302  30.712 1 40.999  ? 536  PRO A CD  1 
ATOM   4268 N  N   . LEU A 1 519 ? -34.989 12.323 30.314 1 44.402  ? 537  LEU A N   1 
ATOM   4269 C  CA  . LEU A 1 519 ? -33.683 12.87  30.661 1 38.74   ? 537  LEU A CA  1 
ATOM   4270 C  C   . LEU A 1 519 ? -33.366 12.644 32.133 1 38.178  ? 537  LEU A C   1 
ATOM   4271 O  O   . LEU A 1 519 ? -32.232 12.318 32.479 1 37.914  ? 537  LEU A O   1 
ATOM   4272 C  CB  . LEU A 1 519 ? -33.7   14.349 30.327 1 37.491  ? 537  LEU A CB  1 
ATOM   4273 C  CG  . LEU A 1 519 ? -32.334 15.026 30.314 1 41.636  ? 537  LEU A CG  1 
ATOM   4274 C  CD1 . LEU A 1 519 ? -31.256 14.137 29.72  1 41.254  ? 537  LEU A CD1 1 
ATOM   4275 C  CD2 . LEU A 1 519 ? -32.49  16.33  29.532 1 40.915  ? 537  LEU A CD2 1 
ATOM   4276 N  N   . ASP A 1 520 ? -34.4   12.752 32.978 1 37.181  ? 538  ASP A N   1 
ATOM   4277 C  CA  . ASP A 1 520 ? -34.236 12.727 34.426 1 38.881  ? 538  ASP A CA  1 
ATOM   4278 C  C   . ASP A 1 520 ? -34.127 11.304 34.992 1 38.993  ? 538  ASP A C   1 
ATOM   4279 O  O   . ASP A 1 520 ? -34.112 11.125 36.21  1 35.632  ? 538  ASP A O   1 
ATOM   4280 C  CB  . ASP A 1 520 ? -35.384 13.471 35.095 1 38.387  ? 538  ASP A CB  1 
ATOM   4281 C  CG  . ASP A 1 520 ? -36.791 13.045 34.685 1 36.911  ? 538  ASP A CG  1 
ATOM   4282 O  OD1 . ASP A 1 520 ? -37.165 13.319 33.523 1 32.719  ? 538  ASP A OD1 1 
ATOM   4283 O  OD2 . ASP A 1 520 ? -37.494 12.453 35.534 1 36.643  ? 538  ASP A OD2 1 
ATOM   4284 N  N   . ASN A 1 521 ? -34.085 10.266 34.149 1 38.728  ? 539  ASN A N   1 
ATOM   4285 C  CA  . ASN A 1 521 ? -33.725 8.957  34.686 1 43.066  ? 539  ASN A CA  1 
ATOM   4286 C  C   . ASN A 1 521 ? -32.588 8.34   33.862 1 43.442  ? 539  ASN A C   1 
ATOM   4287 O  O   . ASN A 1 521 ? -32.397 7.13   33.888 1 39.559  ? 539  ASN A O   1 
ATOM   4288 C  CB  . ASN A 1 521 ? -34.965 8.089  34.892 1 37.675  ? 539  ASN A CB  1 
ATOM   4289 C  CG  . ASN A 1 521 ? -34.757 7.003  35.918 1 39.807  ? 539  ASN A CG  1 
ATOM   4290 O  OD1 . ASN A 1 521 ? -34.081 7.172  36.944 1 46.964  ? 539  ASN A OD1 1 
ATOM   4291 N  ND2 . ASN A 1 521 ? -35.314 5.843  35.643 1 42.114  ? 539  ASN A ND2 1 
ATOM   4292 N  N   . CYS A 1 522 ? -31.771 9.183  33.214 1 42.287  ? 540  CYS A N   1 
ATOM   4293 C  CA  . CYS A 1 522 ? -30.644 8.704  32.425 1 43.546  ? 540  CYS A CA  1 
ATOM   4294 C  C   . CYS A 1 522 ? -29.478 8.3    33.343 1 42.24   ? 540  CYS A C   1 
ATOM   4295 O  O   . CYS A 1 522 ? -29.096 9.065  34.239 1 41.31   ? 540  CYS A O   1 
ATOM   4296 C  CB  . CYS A 1 522 ? -30.253 9.726  31.357 1 44.256  ? 540  CYS A CB  1 
ATOM   4297 S  SG  . CYS A 1 522 ? -28.473 9.704  31.021 1 48.319  ? 540  CYS A SG  1 
ATOM   4298 N  N   . ASP A 1 523 ? -28.957 7.073  33.135 1 35.222  ? 541  ASP A N   1 
ATOM   4299 C  CA  . ASP A 1 523 ? -27.698 6.621  33.718 1 38.591  ? 541  ASP A CA  1 
ATOM   4300 C  C   . ASP A 1 523 ? -26.648 6.42   32.617 1 40.14   ? 541  ASP A C   1 
ATOM   4301 O  O   . ASP A 1 523 ? -26.874 5.68   31.668 1 40.144  ? 541  ASP A O   1 
ATOM   4302 C  CB  . ASP A 1 523 ? -27.868 5.338  34.514 1 39.706  ? 541  ASP A CB  1 
ATOM   4303 C  CG  . ASP A 1 523 ? -26.708 5.004  35.449 1 46.671  ? 541  ASP A CG  1 
ATOM   4304 O  OD1 . ASP A 1 523 ? -25.745 5.808  35.491 1 40.651  ? 541  ASP A OD1 1 
ATOM   4305 O  OD2 . ASP A 1 523 ? -26.777 3.96   36.156 1 41.122  ? 541  ASP A OD2 1 
ATOM   4306 N  N   . ILE A 1 524 ? -25.493 7.091  32.727 1 41.042  ? 542  ILE A N   1 
ATOM   4307 C  CA  . ILE A 1 524 ? -24.434 6.958  31.73  1 38.516  ? 542  ILE A CA  1 
ATOM   4308 C  C   . ILE A 1 524 ? -23.347 6.011  32.236 1 34.582  ? 542  ILE A C   1 
ATOM   4309 O  O   . ILE A 1 524 ? -22.338 5.871  31.567 1 36.347  ? 542  ILE A O   1 
ATOM   4310 C  CB  . ILE A 1 524 ? -23.806 8.308  31.311 1 35.195  ? 542  ILE A CB  1 
ATOM   4311 C  CG1 . ILE A 1 524 ? -22.985 8.947  32.451 1 33.848  ? 542  ILE A CG1 1 
ATOM   4312 C  CG2 . ILE A 1 524 ? -24.852 9.246  30.728 1 33.663  ? 542  ILE A CG2 1 
ATOM   4313 C  CD1 . ILE A 1 524 ? -22.331 10.27  32.091 1 34.425  ? 542  ILE A CD1 1 
ATOM   4314 N  N   . TYR A 1 525 ? -23.512 5.419  33.424 1 34.934  ? 543  TYR A N   1 
ATOM   4315 C  CA  . TYR A 1 525 ? -22.627 4.357  33.886 1 40.011  ? 543  TYR A CA  1 
ATOM   4316 C  C   . TYR A 1 525 ? -22.418 3.339  32.762 1 41.689  ? 543  TYR A C   1 
ATOM   4317 O  O   . TYR A 1 525 ? -23.37  2.936  32.096 1 38.688  ? 543  TYR A O   1 
ATOM   4318 C  CB  . TYR A 1 525 ? -23.198 3.633  35.106 1 39.073  ? 543  TYR A CB  1 
ATOM   4319 C  CG  . TYR A 1 525 ? -22.255 2.573  35.619 1 41.2    ? 543  TYR A CG  1 
ATOM   4320 C  CD1 . TYR A 1 525 ? -21.255 2.897  36.52  1 43.966  ? 543  TYR A CD1 1 
ATOM   4321 C  CD2 . TYR A 1 525 ? -22.353 1.251  35.196 1 44.262  ? 543  TYR A CD2 1 
ATOM   4322 C  CE1 . TYR A 1 525 ? -20.365 1.94   36.984 1 46.333  ? 543  TYR A CE1 1 
ATOM   4323 C  CE2 . TYR A 1 525 ? -21.458 0.289  35.643 1 38.033  ? 543  TYR A CE2 1 
ATOM   4324 C  CZ  . TYR A 1 525 ? -20.459 0.636  36.531 1 41.126  ? 543  TYR A CZ  1 
ATOM   4325 O  OH  . TYR A 1 525 ? -19.564 -0.288 36.98  1 40.182  ? 543  TYR A OH  1 
ATOM   4326 N  N   . GLY A 1 526 ? -21.152 2.999  32.503 1 43.225  ? 544  GLY A N   1 
ATOM   4327 C  CA  . GLY A 1 526 ? -20.822 1.965  31.542 1 44.531  ? 544  GLY A CA  1 
ATOM   4328 C  C   . GLY A 1 526 ? -20.768 2.46   30.095 1 45.697  ? 544  GLY A C   1 
ATOM   4329 O  O   . GLY A 1 526 ? -20.331 1.706  29.233 1 44.359  ? 544  GLY A O   1 
ATOM   4330 N  N   . SER A 1 527 ? -21.17  3.709  29.813 1 41.621  ? 545  SER A N   1 
ATOM   4331 C  CA  . SER A 1 527 ? -21.186 4.182  28.433 1 42.347  ? 545  SER A CA  1 
ATOM   4332 C  C   . SER A 1 527 ? -19.8   4.655  27.995 1 42.234  ? 545  SER A C   1 
ATOM   4333 O  O   . SER A 1 527 ? -19.325 5.704  28.413 1 45.912  ? 545  SER A O   1 
ATOM   4334 C  CB  . SER A 1 527 ? -22.197 5.259  28.18  1 38.804  ? 545  SER A CB  1 
ATOM   4335 O  OG  . SER A 1 527 ? -21.992 5.783  26.866 1 41.811  ? 545  SER A OG  1 
ATOM   4336 N  N   . ALA A 1 528 ? -19.205 3.9    27.074 1 43.961  ? 546  ALA A N   1 
ATOM   4337 C  CA  . ALA A 1 528 ? -17.964 4.278  26.434 1 43.073  ? 546  ALA A CA  1 
ATOM   4338 C  C   . ALA A 1 528 ? -18.241 5.336  25.377 1 39.714  ? 546  ALA A C   1 
ATOM   4339 O  O   . ALA A 1 528 ? -17.327 6.077  25.035 1 38.339  ? 546  ALA A O   1 
ATOM   4340 C  CB  . ALA A 1 528 ? -17.276 3.08   25.832 1 41.537  ? 546  ALA A CB  1 
ATOM   4341 N  N   . ALA A 1 529 ? -19.481 5.45   24.883 1 37.279  ? 547  ALA A N   1 
ATOM   4342 C  CA  . ALA A 1 529 ? -19.766 6.538  23.945 1 41.912  ? 547  ALA A CA  1 
ATOM   4343 C  C   . ALA A 1 529 ? -19.617 7.912  24.627 1 47.327  ? 547  ALA A C   1 
ATOM   4344 O  O   . ALA A 1 529 ? -18.979 8.815  24.065 1 42.63   ? 547  ALA A O   1 
ATOM   4345 C  CB  . ALA A 1 529 ? -21.126 6.374  23.326 1 42.479  ? 547  ALA A CB  1 
ATOM   4346 N  N   . ALA A 1 530 ? -20.162 8.019  25.859 1 43.347  ? 548  ALA A N   1 
ATOM   4347 C  CA  . ALA A 1 530 ? -20.08  9.227  26.673 1 43.915  ? 548  ALA A CA  1 
ATOM   4348 C  C   . ALA A 1 530 ? -18.642 9.491  27.09  1 42.495  ? 548  ALA A C   1 
ATOM   4349 O  O   . ALA A 1 530 ? -18.201 10.639 27.057 1 41.549  ? 548  ALA A O   1 
ATOM   4350 C  CB  . ALA A 1 530 ? -20.949 9.134  27.915 1 38.298  ? 548  ALA A CB  1 
ATOM   4351 N  N   . GLY A 1 531 ? -17.965 8.427  27.536 1 39.444  ? 549  GLY A N   1 
ATOM   4352 C  CA  . GLY A 1 531 ? -16.561 8.484  27.915 1 39.029  ? 549  GLY A CA  1 
ATOM   4353 C  C   . GLY A 1 531 ? -15.668 9.077  26.818 1 36.283  ? 549  GLY A C   1 
ATOM   4354 O  O   . GLY A 1 531 ? -14.77  9.858  27.12  1 37.698  ? 549  GLY A O   1 
ATOM   4355 N  N   . ALA A 1 532 ? -15.924 8.691  25.559 1 35.892  ? 550  ALA A N   1 
ATOM   4356 C  CA  . ALA A 1 532 ? -15.182 9.171  24.399 1 37.982  ? 550  ALA A CA  1 
ATOM   4357 C  C   . ALA A 1 532 ? -15.342 10.688 24.262 1 39.568  ? 550  ALA A C   1 
ATOM   4358 O  O   . ALA A 1 532 ? -14.363 11.405 24.125 1 41.893  ? 550  ALA A O   1 
ATOM   4359 C  CB  . ALA A 1 532 ? -15.67  8.471  23.143 1 36.735  ? 550  ALA A CB  1 
ATOM   4360 N  N   . ALA A 1 533 ? -16.588 11.172 24.34  1 42.247  ? 551  ALA A N   1 
ATOM   4361 C  CA  . ALA A 1 533 ? -16.874 12.595 24.28  1 40.58   ? 551  ALA A CA  1 
ATOM   4362 C  C   . ALA A 1 533 ? -16.081 13.349 25.361 1 38.228  ? 551  ALA A C   1 
ATOM   4363 O  O   . ALA A 1 533 ? -15.34  14.285 25.06  1 43.98   ? 551  ALA A O   1 
ATOM   4364 C  CB  . ALA A 1 533 ? -18.367 12.778 24.383 1 39.928  ? 551  ALA A CB  1 
ATOM   4365 N  N   . PHE A 1 534 ? -16.145 12.87  26.605 1 35.63   ? 552  PHE A N   1 
ATOM   4366 C  CA  . PHE A 1 534 ? -15.368 13.423 27.704 1 39.607  ? 552  PHE A CA  1 
ATOM   4367 C  C   . PHE A 1 534 ? -13.863 13.426 27.406 1 41.16   ? 552  PHE A C   1 
ATOM   4368 O  O   . PHE A 1 534 ? -13.177 14.385 27.752 1 40.651  ? 552  PHE A O   1 
ATOM   4369 C  CB  . PHE A 1 534 ? -15.608 12.722 29.049 1 41.381  ? 552  PHE A CB  1 
ATOM   4370 C  CG  . PHE A 1 534 ? -16.818 13.238 29.81  1 48.327  ? 552  PHE A CG  1 
ATOM   4371 C  CD1 . PHE A 1 534 ? -16.809 14.507 30.374 1 56.917  ? 552  PHE A CD1 1 
ATOM   4372 C  CD2 . PHE A 1 534 ? -17.953 12.46  29.966 1 50.296  ? 552  PHE A CD2 1 
ATOM   4373 C  CE1 . PHE A 1 534 ? -17.916 14.986 31.051 1 61.381  ? 552  PHE A CE1 1 
ATOM   4374 C  CE2 . PHE A 1 534 ? -19.044 12.931 30.675 1 55.502  ? 552  PHE A CE2 1 
ATOM   4375 C  CZ  . PHE A 1 534 ? -19.03  14.192 31.203 1 60.025  ? 552  PHE A CZ  1 
ATOM   4376 N  N   . HIS A 1 535 ? -13.335 12.327 26.861 1 39.123  ? 553  HIS A N   1 
ATOM   4377 C  CA  . HIS A 1 535 ? -11.916 12.242 26.56  1 38.773  ? 553  HIS A CA  1 
ATOM   4378 C  C   . HIS A 1 535 ? -11.53  13.317 25.533 1 36.683  ? 553  HIS A C   1 
ATOM   4379 O  O   . HIS A 1 535 ? -10.552 14.058 25.691 1 33.495  ? 553  HIS A O   1 
ATOM   4380 C  CB  . HIS A 1 535 ? -11.564 10.813 26.11  1 41.266  ? 553  HIS A CB  1 
ATOM   4381 C  CG  . HIS A 1 535 ? -10.191 10.727 25.55  1 43.437  ? 553  HIS A CG  1 
ATOM   4382 N  ND1 . HIS A 1 535 ? -9.08   10.87  26.354 1 41.908  ? 553  HIS A ND1 1 
ATOM   4383 C  CD2 . HIS A 1 535 ? -9.749  10.658 24.284 1 42.29   ? 553  HIS A CD2 1 
ATOM   4384 C  CE1 . HIS A 1 535 ? -7.994  10.827 25.593 1 44.765  ? 553  HIS A CE1 1 
ATOM   4385 N  NE2 . HIS A 1 535 ? -8.377  10.711 24.332 1 43.778  ? 553  HIS A NE2 1 
ATOM   4386 N  N   . ASN A 1 536 ? -12.335 13.436 24.481 1 36.109  ? 554  ASN A N   1 
ATOM   4387 C  CA  . ASN A 1 536 ? -12.061 14.414 23.441 1 42.957  ? 554  ASN A CA  1 
ATOM   4388 C  C   . ASN A 1 536 ? -11.964 15.822 24.023 1 40.764  ? 554  ASN A C   1 
ATOM   4389 O  O   . ASN A 1 536 ? -11.18  16.616 23.516 1 37.878  ? 554  ASN A O   1 
ATOM   4390 C  CB  . ASN A 1 536 ? -13.094 14.394 22.322 1 43.848  ? 554  ASN A CB  1 
ATOM   4391 C  CG  . ASN A 1 536 ? -13.114 13.062 21.615 1 49.493  ? 554  ASN A CG  1 
ATOM   4392 O  OD1 . ASN A 1 536 ? -12.169 12.274 21.716 1 61.381  ? 554  ASN A OD1 1 
ATOM   4393 N  ND2 . ASN A 1 536 ? -14.19  12.781 20.905 1 57.148  ? 554  ASN A ND2 1 
ATOM   4394 N  N   . MET A 1 537 ? -12.759 16.129 25.06  1 37.531  ? 555  MET A N   1 
ATOM   4395 C  CA  . MET A 1 537 ? -12.863 17.502 25.517 1 33.489  ? 555  MET A CA  1 
ATOM   4396 C  C   . MET A 1 537 ? -11.84  17.738 26.615 1 33.473  ? 555  MET A C   1 
ATOM   4397 O  O   . MET A 1 537 ? -11.086 18.702 26.547 1 34.98   ? 555  MET A O   1 
ATOM   4398 C  CB  . MET A 1 537 ? -14.282 17.806 25.99  1 36.883  ? 555  MET A CB  1 
ATOM   4399 C  CG  . MET A 1 537 ? -14.422 19.133 26.732 1 39.369  ? 555  MET A CG  1 
ATOM   4400 S  SD  . MET A 1 537 ? -16.124 19.475 27.213 1 40.05   ? 555  MET A SD  1 
ATOM   4401 C  CE  . MET A 1 537 ? -16.231 18.486 28.711 1 39.237  ? 555  MET A CE  1 
ATOM   4402 N  N   . LEU A 1 538 ? -11.8   16.841 27.606 1 33.574  ? 556  LEU A N   1 
ATOM   4403 C  CA  . LEU A 1 538 ? -10.955 17.027 28.777 1 33.68   ? 556  LEU A CA  1 
ATOM   4404 C  C   . LEU A 1 538 ? -9.476  16.997 28.4   1 35.261  ? 556  LEU A C   1 
ATOM   4405 O  O   . LEU A 1 538 ? -8.678  17.724 28.98  1 34.057  ? 556  LEU A O   1 
ATOM   4406 C  CB  . LEU A 1 538 ? -11.26  15.989 29.851 1 32.302  ? 556  LEU A CB  1 
ATOM   4407 C  CG  . LEU A 1 538 ? -12.695 15.969 30.377 1 34.926  ? 556  LEU A CG  1 
ATOM   4408 C  CD1 . LEU A 1 538 ? -12.741 14.935 31.476 1 34.671  ? 556  LEU A CD1 1 
ATOM   4409 C  CD2 . LEU A 1 538 ? -13.192 17.341 30.88  1 33.511  ? 556  LEU A CD2 1 
ATOM   4410 N  N   . SER A 1 539 ? -9.106  16.181 27.409 1 36.516  ? 557  SER A N   1 
ATOM   4411 C  CA  . SER A 1 539 ? -7.702  16.039 27.071 1 36.234  ? 557  SER A CA  1 
ATOM   4412 C  C   . SER A 1 539 ? -7.173  17.325 26.45  1 35.109  ? 557  SER A C   1 
ATOM   4413 O  O   . SER A 1 539 ? -5.958  17.517 26.43  1 28.22   ? 557  SER A O   1 
ATOM   4414 C  CB  . SER A 1 539 ? -7.457  14.859 26.169 1 36.218  ? 557  SER A CB  1 
ATOM   4415 O  OG  . SER A 1 539 ? -8.169  15.043 24.956 1 39.355  ? 557  SER A OG  1 
ATOM   4416 N  N   . MET A 1 540 ? -8.078  18.209 25.983 1 34.167  ? 558  MET A N   1 
ATOM   4417 C  CA  . MET A 1 540 ? -7.655  19.481 25.404 1 32.812  ? 558  MET A CA  1 
ATOM   4418 C  C   . MET A 1 540 ? -7.094  20.442 26.451 1 29.67   ? 558  MET A C   1 
ATOM   4419 O  O   . MET A 1 540 ? -6.309  21.31  26.093 1 32.755  ? 558  MET A O   1 
ATOM   4420 C  CB  . MET A 1 540 ? -8.791  20.162 24.634 1 33.057  ? 558  MET A CB  1 
ATOM   4421 C  CG  . MET A 1 540 ? -9.233  19.36  23.443 1 32.67   ? 558  MET A CG  1 
ATOM   4422 S  SD  . MET A 1 540 ? -10.696 20.015 22.63  1 40.036  ? 558  MET A SD  1 
ATOM   4423 C  CE  . MET A 1 540 ? -10.063 21.672 22.335 1 38.693  ? 558  MET A CE  1 
ATOM   4424 N  N   . GLY A 1 541 ? -7.472  20.299 27.726 1 28.599  ? 559  GLY A N   1 
ATOM   4425 C  CA  . GLY A 1 541 ? -7.153  21.296 28.746 1 29.712  ? 559  GLY A CA  1 
ATOM   4426 C  C   . GLY A 1 541 ? -7.609  22.697 28.305 1 31.058  ? 559  GLY A C   1 
ATOM   4427 O  O   . GLY A 1 541 ? -8.714  22.867 27.806 1 28.503  ? 559  GLY A O   1 
ATOM   4428 N  N   . ALA A 1 542 ? -6.695  23.676 28.393 1 31.07   ? 560  ALA A N   1 
ATOM   4429 C  CA  . ALA A 1 542 ? -6.954  25.046 27.989 1 32.772  ? 560  ALA A CA  1 
ATOM   4430 C  C   . ALA A 1 542 ? -6.193  25.37  26.703 1 34.931  ? 560  ALA A C   1 
ATOM   4431 O  O   . ALA A 1 542 ? -5.82   26.518 26.495 1 33.941  ? 560  ALA A O   1 
ATOM   4432 C  CB  . ALA A 1 542 ? -6.548  26.004 29.102 1 30.317  ? 560  ALA A CB  1 
ATOM   4433 N  N   . SER A 1 543 ? -6.011  24.364 25.842 1 33.952  ? 561  SER A N   1 
ATOM   4434 C  CA  . SER A 1 543 ? -5.18   24.484 24.654 1 32.401  ? 561  SER A CA  1 
ATOM   4435 C  C   . SER A 1 543 ? -5.911  25.314 23.606 1 30.317  ? 561  SER A C   1 
ATOM   4436 O  O   . SER A 1 543 ? -5.284  25.889 22.726 1 30.858  ? 561  SER A O   1 
ATOM   4437 C  CB  . SER A 1 543 ? -4.784  23.107 24.087 1 30.638  ? 561  SER A CB  1 
ATOM   4438 O  OG  . SER A 1 543 ? -5.92   22.348 23.654 1 27.956  ? 561  SER A OG  1 
ATOM   4439 N  N   . LYS A 1 544 ? -7.24   25.313 23.705 1 34.675  ? 562  LYS A N   1 
ATOM   4440 C  CA  . LYS A 1 544 ? -8.119  26.093 22.851 1 39.88   ? 562  LYS A CA  1 
ATOM   4441 C  C   . LYS A 1 544 ? -9.128  26.889 23.673 1 36.506  ? 562  LYS A C   1 
ATOM   4442 O  O   . LYS A 1 544 ? -9.504  26.501 24.774 1 33.83   ? 562  LYS A O   1 
ATOM   4443 C  CB  . LYS A 1 544 ? -8.945  25.17  21.953 1 48.76   ? 562  LYS A CB  1 
ATOM   4444 C  CG  . LYS A 1 544 ? -8.14   24.28  21.031 1 53.122  ? 562  LYS A CG  1 
ATOM   4445 C  CD  . LYS A 1 544 ? -7.502  25.058 19.899 1 58.27   ? 562  LYS A CD  1 
ATOM   4446 C  CE  . LYS A 1 544 ? -6.789  24.098 19.029 1 66.812  ? 562  LYS A CE  1 
ATOM   4447 N  NZ  . LYS A 1 544 ? -6.381  24.798 17.815 1 79.171  ? 562  LYS A NZ  1 
ATOM   4448 N  N   . PRO A 1 545 ? -9.687  27.984 23.119 1 38.068  ? 563  PRO A N   1 
ATOM   4449 C  CA  . PRO A 1 545 ? -10.818 28.638 23.769 1 38.441  ? 563  PRO A CA  1 
ATOM   4450 C  C   . PRO A 1 545 ? -11.951 27.645 24.035 1 36.093  ? 563  PRO A C   1 
ATOM   4451 O  O   . PRO A 1 545 ? -12.124 26.691 23.281 1 32.208  ? 563  PRO A O   1 
ATOM   4452 C  CB  . PRO A 1 545 ? -11.234 29.726 22.772 1 35.695  ? 563  PRO A CB  1 
ATOM   4453 C  CG  . PRO A 1 545 ? -10.048 29.87  21.839 1 35.37   ? 563  PRO A CG  1 
ATOM   4454 C  CD  . PRO A 1 545 ? -9.358  28.544 21.797 1 34.409  ? 563  PRO A CD  1 
ATOM   4455 N  N   . TRP A 1 546 ? -12.767 27.914 25.059 1 33.315  ? 564  TRP A N   1 
ATOM   4456 C  CA  . TRP A 1 546 ? -13.704 26.923 25.554 1 33.821  ? 564  TRP A CA  1 
ATOM   4457 C  C   . TRP A 1 546 ? -14.741 26.539 24.494 1 33.194  ? 564  TRP A C   1 
ATOM   4458 O  O   . TRP A 1 546 ? -15.162 25.399 24.457 1 32.737  ? 564  TRP A O   1 
ATOM   4459 C  CB  . TRP A 1 546 ? -14.342 27.343 26.895 1 35.624  ? 564  TRP A CB  1 
ATOM   4460 C  CG  . TRP A 1 546 ? -15.205 28.577 26.867 1 35.613  ? 564  TRP A CG  1 
ATOM   4461 C  CD1 . TRP A 1 546 ? -14.846 29.861 27.175 1 34.603  ? 564  TRP A CD1 1 
ATOM   4462 C  CD2 . TRP A 1 546 ? -16.594 28.636 26.486 1 35.041  ? 564  TRP A CD2 1 
ATOM   4463 N  NE1 . TRP A 1 546 ? -15.917 30.702 27.034 1 32.388  ? 564  TRP A NE1 1 
ATOM   4464 C  CE2 . TRP A 1 546 ? -16.994 29.99  26.592 1 33.232  ? 564  TRP A CE2 1 
ATOM   4465 C  CE3 . TRP A 1 546 ? -17.524 27.692 26.047 1 33.117  ? 564  TRP A CE3 1 
ATOM   4466 C  CZ2 . TRP A 1 546 ? -18.288 30.407 26.294 1 33.13   ? 564  TRP A CZ2 1 
ATOM   4467 C  CZ3 . TRP A 1 546 ? -18.804 28.111 25.748 1 34.416  ? 564  TRP A CZ3 1 
ATOM   4468 C  CH2 . TRP A 1 546 ? -19.183 29.447 25.887 1 33.099  ? 564  TRP A CH2 1 
ATOM   4469 N  N   . PRO A 1 547 ? -15.213 27.42  23.588 1 34.773  ? 565  PRO A N   1 
ATOM   4470 C  CA  . PRO A 1 547 ? -16.187 26.983 22.605 1 34.014  ? 565  PRO A CA  1 
ATOM   4471 C  C   . PRO A 1 547 ? -15.691 25.799 21.793 1 36.468  ? 565  PRO A C   1 
ATOM   4472 O  O   . PRO A 1 547 ? -16.497 25.002 21.314 1 35.592  ? 565  PRO A O   1 
ATOM   4473 C  CB  . PRO A 1 547 ? -16.405 28.234 21.749 1 35.122  ? 565  PRO A CB  1 
ATOM   4474 C  CG  . PRO A 1 547 ? -16.098 29.371 22.71  1 32.949  ? 565  PRO A CG  1 
ATOM   4475 C  CD  . PRO A 1 547 ? -14.919 28.863 23.487 1 33.866  ? 565  PRO A CD  1 
ATOM   4476 N  N   . ASP A 1 548 ? -14.362 25.729 21.636 1 35.388  ? 566  ASP A N   1 
ATOM   4477 C  CA  . ASP A 1 548 ? -13.743 24.671 20.856 1 36.062  ? 566  ASP A CA  1 
ATOM   4478 C  C   . ASP A 1 548 ? -13.772 23.374 21.651 1 33.678  ? 566  ASP A C   1 
ATOM   4479 O  O   . ASP A 1 548 ? -13.871 22.308 21.07  1 36.417  ? 566  ASP A O   1 
ATOM   4480 C  CB  . ASP A 1 548 ? -12.325 25.01  20.416 1 40.301  ? 566  ASP A CB  1 
ATOM   4481 C  CG  . ASP A 1 548 ? -12.162 26.179 19.444 1 42.155  ? 566  ASP A CG  1 
ATOM   4482 O  OD1 . ASP A 1 548 ? -12.947 26.279 18.5   1 49.838  ? 566  ASP A OD1 1 
ATOM   4483 O  OD2 . ASP A 1 548 ? -11.214 26.96  19.599 1 48.935  ? 566  ASP A OD2 1 
ATOM   4484 N  N   . ALA A 1 549 ? -13.688 23.464 22.981 1 33.547  ? 567  ALA A N   1 
ATOM   4485 C  CA  . ALA A 1 549 ? -13.7   22.288 23.838 1 33.698  ? 567  ALA A CA  1 
ATOM   4486 C  C   . ALA A 1 549 ? -15.111 21.701 23.883 1 33.958  ? 567  ALA A C   1 
ATOM   4487 O  O   . ALA A 1 549 ? -15.294 20.487 23.87  1 36.236  ? 567  ALA A O   1 
ATOM   4488 C  CB  . ALA A 1 549 ? -13.198 22.641 25.236 1 33.057  ? 567  ALA A CB  1 
ATOM   4489 N  N   . LEU A 1 550 ? -16.103 22.578 23.982 1 29.921  ? 568  LEU A N   1 
ATOM   4490 C  CA  . LEU A 1 550 ? -17.479 22.141 23.954 1 32.24   ? 568  LEU A CA  1 
ATOM   4491 C  C   . LEU A 1 550 ? -17.783 21.486 22.612 1 31.81   ? 568  LEU A C   1 
ATOM   4492 O  O   . LEU A 1 550 ? -18.481 20.493 22.586 1 32.98   ? 568  LEU A O   1 
ATOM   4493 C  CB  . LEU A 1 550 ? -18.372 23.346 24.224 1 33.794  ? 568  LEU A CB  1 
ATOM   4494 C  CG  . LEU A 1 550 ? -19.877 23.117 24.09  1 34.354  ? 568  LEU A CG  1 
ATOM   4495 C  CD1 . LEU A 1 550 ? -20.435 22.086 25.055 1 33.665  ? 568  LEU A CD1 1 
ATOM   4496 C  CD2 . LEU A 1 550 ? -20.533 24.467 24.296 1 36.037  ? 568  LEU A CD2 1 
ATOM   4497 N  N   . GLU A 1 551 ? -17.267 22.046 21.515 1 35.899  ? 569  GLU A N   1 
ATOM   4498 C  CA  . GLU A 1 551 ? -17.512 21.524 20.174 1 39.312  ? 569  GLU A CA  1 
ATOM   4499 C  C   . GLU A 1 551 ? -16.973 20.098 20.053 1 38.942  ? 569  GLU A C   1 
ATOM   4500 O  O   . GLU A 1 551 ? -17.539 19.302 19.333 1 41.178  ? 569  GLU A O   1 
ATOM   4501 C  CB  . GLU A 1 551 ? -16.844 22.414 19.125 1 44.024  ? 569  GLU A CB  1 
ATOM   4502 C  CG  . GLU A 1 551 ? -17.226 22.093 17.679 1 51.424  ? 569  GLU A CG  1 
ATOM   4503 C  CD  . GLU A 1 551 ? -16.688 23.033 16.594 1 54.16   ? 569  GLU A CD  1 
ATOM   4504 O  OE1 . GLU A 1 551 ? -15.74  23.827 16.786 1 55.953  ? 569  GLU A OE1 1 
ATOM   4505 O  OE2 . GLU A 1 551 ? -17.284 22.991 15.508 1 61.156  ? 569  GLU A OE2 1 
ATOM   4506 N  N   . ALA A 1 552 ? -15.876 19.807 20.757 1 35.898  ? 570  ALA A N   1 
ATOM   4507 C  CA  . ALA A 1 552 ? -15.244 18.505 20.764 1 38.327  ? 570  ALA A CA  1 
ATOM   4508 C  C   . ALA A 1 552 ? -16.134 17.502 21.473 1 41.121  ? 570  ALA A C   1 
ATOM   4509 O  O   . ALA A 1 552 ? -16.094 16.321 21.147 1 44.552  ? 570  ALA A O   1 
ATOM   4510 C  CB  . ALA A 1 552 ? -13.906 18.571 21.455 1 37.669  ? 570  ALA A CB  1 
ATOM   4511 N  N   . PHE A 1 553 ? -16.899 17.984 22.458 1 40.014  ? 571  PHE A N   1 
ATOM   4512 C  CA  . PHE A 1 553 ? -17.738 17.116 23.266 1 36.855  ? 571  PHE A CA  1 
ATOM   4513 C  C   . PHE A 1 553 ? -19.006 16.765 22.495 1 38.449  ? 571  PHE A C   1 
ATOM   4514 O  O   . PHE A 1 553 ? -19.371 15.603 22.483 1 42.43   ? 571  PHE A O   1 
ATOM   4515 C  CB  . PHE A 1 553 ? -18.076 17.723 24.625 1 34.433  ? 571  PHE A CB  1 
ATOM   4516 C  CG  . PHE A 1 553 ? -18.896 16.824 25.53  1 32.611  ? 571  PHE A CG  1 
ATOM   4517 C  CD1 . PHE A 1 553 ? -20.272 16.769 25.422 1 38.304  ? 571  PHE A CD1 1 
ATOM   4518 C  CD2 . PHE A 1 553 ? -18.289 16.019 26.48  1 39.374  ? 571  PHE A CD2 1 
ATOM   4519 C  CE1 . PHE A 1 553 ? -21.016 15.917 26.235 1 41.74   ? 571  PHE A CE1 1 
ATOM   4520 C  CE2 . PHE A 1 553 ? -19.041 15.186 27.316 1 42.618  ? 571  PHE A CE2 1 
ATOM   4521 C  CZ  . PHE A 1 553 ? -20.402 15.128 27.181 1 37.958  ? 571  PHE A CZ  1 
ATOM   4522 N  N   . ASN A 1 554 ? -19.644 17.74  21.837 1 39.666  ? 572  ASN A N   1 
ATOM   4523 C  CA  . ASN A 1 554 ? -20.979 17.521 21.295 1 39.581  ? 572  ASN A CA  1 
ATOM   4524 C  C   . ASN A 1 554 ? -21.278 18.363 20.055 1 40.034  ? 572  ASN A C   1 
ATOM   4525 O  O   . ASN A 1 554 ? -22.429 18.418 19.63  1 41.328  ? 572  ASN A O   1 
ATOM   4526 C  CB  . ASN A 1 554 ? -22.059 17.768 22.342 1 40.326  ? 572  ASN A CB  1 
ATOM   4527 C  CG  . ASN A 1 554 ? -22.264 19.22  22.723 1 42.422  ? 572  ASN A CG  1 
ATOM   4528 O  OD1 . ASN A 1 554 ? -21.641 20.135 22.17  1 41.284  ? 572  ASN A OD1 1 
ATOM   4529 N  ND2 . ASN A 1 554 ? -23.172 19.463 23.656 1 46.879  ? 572  ASN A ND2 1 
ATOM   4530 N  N   . GLY A 1 555 ? -20.275 19.047 19.488 1 38.764  ? 573  GLY A N   1 
ATOM   4531 C  CA  . GLY A 1 555 ? -20.491 19.835 18.279 1 39.116  ? 573  GLY A CA  1 
ATOM   4532 C  C   . GLY A 1 555 ? -21.121 21.216 18.51  1 41.237  ? 573  GLY A C   1 
ATOM   4533 O  O   . GLY A 1 555 ? -21.274 21.97  17.564 1 39.444  ? 573  GLY A O   1 
ATOM   4534 N  N   . GLU A 1 556 ? -21.494 21.592 19.739 1 47.691  ? 574  GLU A N   1 
ATOM   4535 C  CA  . GLU A 1 556 ? -22.023 22.932 19.974 1 48.654  ? 574  GLU A CA  1 
ATOM   4536 C  C   . GLU A 1 556 ? -20.891 23.884 20.383 1 43.429  ? 574  GLU A C   1 
ATOM   4537 O  O   . GLU A 1 556 ? -19.832 23.45  20.82  1 40.251  ? 574  GLU A O   1 
ATOM   4538 C  CB  . GLU A 1 556 ? -23.078 22.933 21.077 1 55.748  ? 574  GLU A CB  1 
ATOM   4539 C  CG  . GLU A 1 556 ? -24.246 21.969 20.888 1 62.271  ? 574  GLU A CG  1 
ATOM   4540 C  CD  . GLU A 1 556 ? -25.261 22.072 22.039 1 76.183  ? 574  GLU A CD  1 
ATOM   4541 O  OE1 . GLU A 1 556 ? -24.97  22.078 23.287 1 62.329  ? 574  GLU A OE1 1 
ATOM   4542 O  OE2 . GLU A 1 556 ? -26.437 22.139 21.632 1 91.537  ? 574  GLU A OE2 1 
ATOM   4543 N  N   . ARG A 1 557 ? -21.131 25.194 20.252 1 42.793  ? 575  ARG A N   1 
ATOM   4544 C  CA  . ARG A 1 557 ? -20.139 26.212 20.567 1 42.972  ? 575  ARG A CA  1 
ATOM   4545 C  C   . ARG A 1 557 ? -20.713 27.273 21.503 1 41.895  ? 575  ARG A C   1 
ATOM   4546 O  O   . ARG A 1 557 ? -20.034 28.261 21.808 1 37.3    ? 575  ARG A O   1 
ATOM   4547 C  CB  . ARG A 1 557 ? -19.628 26.898 19.295 1 44.199  ? 575  ARG A CB  1 
ATOM   4548 C  CG  . ARG A 1 557 ? -18.894 25.913 18.393 1 43.771  ? 575  ARG A CG  1 
ATOM   4549 C  CD  . ARG A 1 557 ? -18.341 26.559 17.145 1 39.635  ? 575  ARG A CD  1 
ATOM   4550 N  NE  . ARG A 1 557 ? -17.473 27.699 17.458 1 40.166  ? 575  ARG A NE  1 
ATOM   4551 C  CZ  . ARG A 1 557 ? -16.189 27.615 17.807 1 42.989  ? 575  ARG A CZ  1 
ATOM   4552 N  NH1 . ARG A 1 557 ? -15.553 26.453 17.85  1 44.85   ? 575  ARG A NH1 1 
ATOM   4553 N  NH2 . ARG A 1 557 ? -15.53  28.705 18.136 1 42.891  ? 575  ARG A NH2 1 
ATOM   4554 N  N   . ILE A 1 558 ? -21.932 27.042 22.006 1 39.687  ? 576  ILE A N   1 
ATOM   4555 C  CA  . ILE A 1 558 ? -22.642 28.08  22.724 1 40.233  ? 576  ILE A CA  1 
ATOM   4556 C  C   . ILE A 1 558 ? -23.08  27.57  24.089 1 37.514  ? 576  ILE A C   1 
ATOM   4557 O  O   . ILE A 1 558 ? -23.668 26.511 24.192 1 39.556  ? 576  ILE A O   1 
ATOM   4558 C  CB  . ILE A 1 558 ? -23.823 28.58  21.885 1 51.18   ? 576  ILE A CB  1 
ATOM   4559 C  CG1 . ILE A 1 558 ? -23.315 29.45  20.73  1 59.564  ? 576  ILE A CG1 1 
ATOM   4560 C  CG2 . ILE A 1 558 ? -24.841 29.323 22.759 1 53.094  ? 576  ILE A CG2 1 
ATOM   4561 C  CD1 . ILE A 1 558 ? -24.392 29.876 19.743 1 66.312  ? 576  ILE A CD1 1 
ATOM   4562 N  N   . MET A 1 559 ? -22.818 28.362 25.134 1 37.727  ? 577  MET A N   1 
ATOM   4563 C  CA  . MET A 1 559 ? -23.425 28.153 26.438 1 34.942  ? 577  MET A CA  1 
ATOM   4564 C  C   . MET A 1 559 ? -24.932 28.436 26.383 1 35.578  ? 577  MET A C   1 
ATOM   4565 O  O   . MET A 1 559 ? -25.343 29.532 26.001 1 33.479  ? 577  MET A O   1 
ATOM   4566 C  CB  . MET A 1 559 ? -22.758 29.082 27.453 1 33.389  ? 577  MET A CB  1 
ATOM   4567 C  CG  . MET A 1 559 ? -23.316 28.945 28.849 1 35.957  ? 577  MET A CG  1 
ATOM   4568 S  SD  . MET A 1 559 ? -22.297 29.829 30.049 1 38.079  ? 577  MET A SD  1 
ATOM   4569 C  CE  . MET A 1 559 ? -22.374 31.509 29.421 1 38.719  ? 577  MET A CE  1 
ATOM   4570 N  N   . SER A 1 560 ? -25.768 27.475 26.808 1 33.487  ? 578  SER A N   1 
ATOM   4571 C  CA  . SER A 1 560 ? -27.202 27.652 26.654 1 35.201  ? 578  SER A CA  1 
ATOM   4572 C  C   . SER A 1 560 ? -27.992 27.149 27.856 1 33.252  ? 578  SER A C   1 
ATOM   4573 O  O   . SER A 1 560 ? -27.682 26.107 28.434 1 33.056  ? 578  SER A O   1 
ATOM   4574 C  CB  . SER A 1 560 ? -27.704 26.963 25.41  1 41.698  ? 578  SER A CB  1 
ATOM   4575 O  OG  . SER A 1 560 ? -29.09  27.242 25.243 1 45.212  ? 578  SER A OG  1 
ATOM   4576 N  N   . GLY A 1 561 ? -29.116 27.828 28.11  1 30.56   ? 579  GLY A N   1 
ATOM   4577 C  CA  . GLY A 1 561 ? -30.078 27.403 29.121 1 33.03   ? 579  GLY A CA  1 
ATOM   4578 C  C   . GLY A 1 561 ? -31.096 26.359 28.644 1 33.122  ? 579  GLY A C   1 
ATOM   4579 O  O   . GLY A 1 561 ? -31.857 25.856 29.455 1 32.603  ? 579  GLY A O   1 
ATOM   4580 N  N   . LYS A 1 562 ? -31.114 26.054 27.34  1 38.744  ? 580  LYS A N   1 
ATOM   4581 C  CA  . LYS A 1 562 ? -32.005 25.077 26.717 1 43.939  ? 580  LYS A CA  1 
ATOM   4582 C  C   . LYS A 1 562 ? -32.002 23.728 27.455 1 38.911  ? 580  LYS A C   1 
ATOM   4583 O  O   . LYS A 1 562 ? -33.065 23.186 27.748 1 33.915  ? 580  LYS A O   1 
ATOM   4584 C  CB  . LYS A 1 562 ? -31.524 25.046 25.262 1 54.246  ? 580  LYS A CB  1 
ATOM   4585 C  CG  . LYS A 1 562 ? -32.394 24.442 24.173 1 69.176  ? 580  LYS A CG  1 
ATOM   4586 C  CD  . LYS A 1 562 ? -32.161 25.156 22.833 1 90.942  ? 580  LYS A CD  1 
ATOM   4587 C  CE  . LYS A 1 562 ? -31.466 24.36  21.738 1 100.877 ? 580  LYS A CE  1 
ATOM   4588 N  NZ  . LYS A 1 562 ? -32.289 23.255 21.232 1 97.13   ? 580  LYS A NZ  1 
ATOM   4589 N  N   . ALA A 1 563 ? -30.829 23.193 27.806 1 32.51   ? 581  ALA A N   1 
ATOM   4590 C  CA  . ALA A 1 563 ? -30.773 21.85  28.358 1 33.507  ? 581  ALA A CA  1 
ATOM   4591 C  C   . ALA A 1 563 ? -31.329 21.779 29.776 1 34.65   ? 581  ALA A C   1 
ATOM   4592 O  O   . ALA A 1 563 ? -32.049 20.825 30.103 1 38.579  ? 581  ALA A O   1 
ATOM   4593 C  CB  . ALA A 1 563 ? -29.366 21.321 28.319 1 34.95   ? 581  ALA A CB  1 
ATOM   4594 N  N   . ILE A 1 564 ? -30.947 22.738 30.633 1 32.195  ? 582  ILE A N   1 
ATOM   4595 C  CA  . ILE A 1 564 ? -31.442 22.744 32.005 1 32.206  ? 582  ILE A CA  1 
ATOM   4596 C  C   . ILE A 1 564 ? -32.968 22.93  32.024 1 32.446  ? 582  ILE A C   1 
ATOM   4597 O  O   . ILE A 1 564 ? -33.652 22.347 32.869 1 33.284  ? 582  ILE A O   1 
ATOM   4598 C  CB  . ILE A 1 564 ? -30.723 23.799 32.868 1 31.575  ? 582  ILE A CB  1 
ATOM   4599 C  CG1 . ILE A 1 564 ? -31.106 23.64  34.318 1 33.285  ? 582  ILE A CG1 1 
ATOM   4600 C  CG2 . ILE A 1 564 ? -31.025 25.219 32.392 1 34.194  ? 582  ILE A CG2 1 
ATOM   4601 C  CD1 . ILE A 1 564 ? -30.089 24.213 35.272 1 36.68   ? 582  ILE A CD1 1 
ATOM   4602 N  N   . ALA A 1 565 ? -33.516 23.695 31.066 1 29.335  ? 583  ALA A N   1 
ATOM   4603 C  CA  . ALA A 1 565 ? -34.953 23.904 30.994 1 35.104  ? 583  ALA A CA  1 
ATOM   4604 C  C   . ALA A 1 565 ? -35.666 22.625 30.529 1 38.575  ? 583  ALA A C   1 
ATOM   4605 O  O   . ALA A 1 565 ? -36.701 22.236 31.086 1 37.375  ? 583  ALA A O   1 
ATOM   4606 C  CB  . ALA A 1 565 ? -35.25  25.099 30.094 1 34.254  ? 583  ALA A CB  1 
ATOM   4607 N  N   . GLU A 1 566 ? -35.079 21.956 29.525 1 40.622  ? 584  GLU A N   1 
ATOM   4608 C  CA  . GLU A 1 566 ? -35.598 20.704 28.995 1 39.607  ? 584  GLU A CA  1 
ATOM   4609 C  C   . GLU A 1 566 ? -35.653 19.675 30.124 1 34.82   ? 584  GLU A C   1 
ATOM   4610 O  O   . GLU A 1 566 ? -36.667 19.031 30.32  1 37.28   ? 584  GLU A O   1 
ATOM   4611 C  CB  . GLU A 1 566 ? -34.724 20.289 27.809 1 42.401  ? 584  GLU A CB  1 
ATOM   4612 C  CG  . GLU A 1 566 ? -35.289 19.17  26.932 1 47.661  ? 584  GLU A CG  1 
ATOM   4613 C  CD  . GLU A 1 566 ? -34.39  18.768 25.762 1 53.48   ? 584  GLU A CD  1 
ATOM   4614 O  OE1 . GLU A 1 566 ? -33.784 19.684 25.168 1 50.131  ? 584  GLU A OE1 1 
ATOM   4615 O  OE2 . GLU A 1 566 ? -34.296 17.567 25.408 1 59.678  ? 584  GLU A OE2 1 
ATOM   4616 N  N   . TYR A 1 567 ? -34.588 19.553 30.914 1 32.274  ? 585  TYR A N   1 
ATOM   4617 C  CA  . TYR A 1 567 ? -34.593 18.642 32.052 1 34.374  ? 585  TYR A CA  1 
ATOM   4618 C  C   . TYR A 1 567 ? -35.765 18.908 33.01  1 34.435  ? 585  TYR A C   1 
ATOM   4619 O  O   . TYR A 1 567 ? -36.432 17.968 33.443 1 30.523  ? 585  TYR A O   1 
ATOM   4620 C  CB  . TYR A 1 567 ? -33.259 18.741 32.781 1 31.286  ? 585  TYR A CB  1 
ATOM   4621 C  CG  . TYR A 1 567 ? -33.044 17.729 33.896 1 32.044  ? 585  TYR A CG  1 
ATOM   4622 C  CD1 . TYR A 1 567 ? -33.628 17.869 35.146 1 34.287  ? 585  TYR A CD1 1 
ATOM   4623 C  CD2 . TYR A 1 567 ? -32.186 16.658 33.721 1 31.34   ? 585  TYR A CD2 1 
ATOM   4624 C  CE1 . TYR A 1 567 ? -33.419 16.939 36.155 1 30.51   ? 585  TYR A CE1 1 
ATOM   4625 C  CE2 . TYR A 1 567 ? -31.962 15.73  34.719 1 27.717  ? 585  TYR A CE2 1 
ATOM   4626 C  CZ  . TYR A 1 567 ? -32.549 15.886 35.952 1 28.707  ? 585  TYR A CZ  1 
ATOM   4627 O  OH  . TYR A 1 567 ? -32.287 14.949 36.918 1 28.571  ? 585  TYR A OH  1 
ATOM   4628 N  N   . PHE A 1 568 ? -36.026 20.183 33.335 1 38.797  ? 586  PHE A N   1 
ATOM   4629 C  CA  . PHE A 1 568 ? -37     20.515 34.373 1 37.893  ? 586  PHE A CA  1 
ATOM   4630 C  C   . PHE A 1 568 ? -38.399 20.837 33.821 1 36.07   ? 586  PHE A C   1 
ATOM   4631 O  O   . PHE A 1 568 ? -39.305 21.073 34.607 1 32.984  ? 586  PHE A O   1 
ATOM   4632 C  CB  . PHE A 1 568 ? -36.464 21.666 35.23  1 31.041  ? 586  PHE A CB  1 
ATOM   4633 C  CG  . PHE A 1 568 ? -35.392 21.204 36.189 1 28.474  ? 586  PHE A CG  1 
ATOM   4634 C  CD1 . PHE A 1 568 ? -35.717 20.394 37.254 1 31.944  ? 586  PHE A CD1 1 
ATOM   4635 C  CD2 . PHE A 1 568 ? -34.071 21.579 36.019 1 31.619  ? 586  PHE A CD2 1 
ATOM   4636 C  CE1 . PHE A 1 568 ? -34.744 19.948 38.115 1 32.981  ? 586  PHE A CE1 1 
ATOM   4637 C  CE2 . PHE A 1 568 ? -33.096 21.121 36.875 1 32.058  ? 586  PHE A CE2 1 
ATOM   4638 C  CZ  . PHE A 1 568 ? -33.435 20.317 37.922 1 35.019  ? 586  PHE A CZ  1 
ATOM   4639 N  N   . GLU A 1 569 ? -38.585 20.819 32.493 1 36.356  ? 587  GLU A N   1 
ATOM   4640 C  CA  . GLU A 1 569 ? -39.859 21.122 31.848 1 37.093  ? 587  GLU A CA  1 
ATOM   4641 C  C   . GLU A 1 569 ? -41.044 20.36  32.453 1 37.294  ? 587  GLU A C   1 
ATOM   4642 O  O   . GLU A 1 569 ? -42.065 20.972 32.732 1 38.985  ? 587  GLU A O   1 
ATOM   4643 C  CB  . GLU A 1 569 ? -39.753 20.877 30.342 1 40.475  ? 587  GLU A CB  1 
ATOM   4644 C  CG  . GLU A 1 569 ? -41.048 21.175 29.597 1 43.79   ? 587  GLU A CG  1 
ATOM   4645 C  CD  . GLU A 1 569 ? -41.456 22.645 29.538 1 54.644  ? 587  GLU A CD  1 
ATOM   4646 O  OE1 . GLU A 1 569 ? -40.728 23.549 30.041 1 50.284  ? 587  GLU A OE1 1 
ATOM   4647 O  OE2 . GLU A 1 569 ? -42.541 22.885 28.942 1 55.453  ? 587  GLU A OE2 1 
ATOM   4648 N  N   . PRO A 1 570 ? -41.014 19.023 32.645 1 36.164  ? 588  PRO A N   1 
ATOM   4649 C  CA  . PRO A 1 570 ? -42.103 18.343 33.34  1 37.436  ? 588  PRO A CA  1 
ATOM   4650 C  C   . PRO A 1 570 ? -42.419 18.89  34.729 1 38.731  ? 588  PRO A C   1 
ATOM   4651 O  O   . PRO A 1 570 ? -43.576 18.864 35.156 1 41.882  ? 588  PRO A O   1 
ATOM   4652 C  CB  . PRO A 1 570 ? -41.667 16.878 33.424 1 37.422  ? 588  PRO A CB  1 
ATOM   4653 C  CG  . PRO A 1 570 ? -40.23  16.863 32.925 1 36.498  ? 588  PRO A CG  1 
ATOM   4654 C  CD  . PRO A 1 570 ? -39.985 18.101 32.142 1 36.522  ? 588  PRO A CD  1 
ATOM   4655 N  N   . LEU A 1 571 ? -41.386 19.369 35.433 1 39.177  ? 589  LEU A N   1 
ATOM   4656 C  CA  . LEU A 1 571 ? -41.555 19.943 36.762 1 36.241  ? 589  LEU A CA  1 
ATOM   4657 C  C   . LEU A 1 571 ? -42.285 21.278 36.632 1 35.485  ? 589  LEU A C   1 
ATOM   4658 O  O   . LEU A 1 571 ? -43.282 21.488 37.296 1 32.909  ? 589  LEU A O   1 
ATOM   4659 C  CB  . LEU A 1 571 ? -40.232 20.124 37.506 1 31.855  ? 589  LEU A CB  1 
ATOM   4660 C  CG  . LEU A 1 571 ? -40.368 20.746 38.9   1 32.557  ? 589  LEU A CG  1 
ATOM   4661 C  CD1 . LEU A 1 571 ? -41.262 19.914 39.791 1 33.11   ? 589  LEU A CD1 1 
ATOM   4662 C  CD2 . LEU A 1 571 ? -39.03  20.964 39.587 1 33.983  ? 589  LEU A CD2 1 
ATOM   4663 N  N   . ARG A 1 572 ? -41.78  22.154 35.761 1 35.894  ? 590  ARG A N   1 
ATOM   4664 C  CA  . ARG A 1 572 ? -42.357 23.464 35.537 1 37.777  ? 590  ARG A CA  1 
ATOM   4665 C  C   . ARG A 1 572 ? -43.854 23.331 35.263 1 43.477  ? 590  ARG A C   1 
ATOM   4666 O  O   . ARG A 1 572 ? -44.67  24.036 35.835 1 46.168  ? 590  ARG A O   1 
ATOM   4667 C  CB  . ARG A 1 572 ? -41.695 24.075 34.303 1 35.03   ? 590  ARG A CB  1 
ATOM   4668 C  CG  . ARG A 1 572 ? -42.145 25.489 33.984 1 38.237  ? 590  ARG A CG  1 
ATOM   4669 C  CD  . ARG A 1 572 ? -41.593 26.047 32.664 1 41.327  ? 590  ARG A CD  1 
ATOM   4670 N  NE  . ARG A 1 572 ? -42.315 25.506 31.508 1 47.34   ? 590  ARG A NE  1 
ATOM   4671 C  CZ  . ARG A 1 572 ? -43.601 25.701 31.219 1 52.093  ? 590  ARG A CZ  1 
ATOM   4672 N  NH1 . ARG A 1 572 ? -44.334 26.561 31.895 1 58.268  ? 590  ARG A NH1 1 
ATOM   4673 N  NH2 . ARG A 1 572 ? -44.156 25.059 30.216 1 57.256  ? 590  ARG A NH2 1 
ATOM   4674 N  N   . VAL A 1 573 ? -44.221 22.417 34.373 1 43.127  ? 591  VAL A N   1 
ATOM   4675 C  CA  . VAL A 1 573 ? -45.613 22.272 34.006 1 44.358  ? 591  VAL A CA  1 
ATOM   4676 C  C   . VAL A 1 573 ? -46.432 21.888 35.236 1 40.257  ? 591  VAL A C   1 
ATOM   4677 O  O   . VAL A 1 573 ? -47.487 22.456 35.492 1 38.396  ? 591  VAL A O   1 
ATOM   4678 C  CB  . VAL A 1 573 ? -45.756 21.233 32.884 1 47.344  ? 591  VAL A CB  1 
ATOM   4679 C  CG1 . VAL A 1 573 ? -47.196 20.744 32.753 1 48.6    ? 591  VAL A CG1 1 
ATOM   4680 C  CG2 . VAL A 1 573 ? -45.237 21.789 31.562 1 46.372  ? 591  VAL A CG2 1 
ATOM   4681 N  N   . TRP A 1 574 ? -45.971 20.888 35.975 1 33.934  ? 592  TRP A N   1 
ATOM   4682 C  CA  . TRP A 1 574 ? -46.707 20.465 37.152 1 34.407  ? 592  TRP A CA  1 
ATOM   4683 C  C   . TRP A 1 574 ? -46.792 21.582 38.202 1 37.665  ? 592  TRP A C   1 
ATOM   4684 O  O   . TRP A 1 574 ? -47.82  21.788 38.842 1 35.835  ? 592  TRP A O   1 
ATOM   4685 C  CB  . TRP A 1 574 ? -46.058 19.225 37.759 1 32.744  ? 592  TRP A CB  1 
ATOM   4686 C  CG  . TRP A 1 574 ? -46.763 18.808 39.012 1 38.276  ? 592  TRP A CG  1 
ATOM   4687 C  CD1 . TRP A 1 574 ? -47.874 18.024 39.074 1 38.184  ? 592  TRP A CD1 1 
ATOM   4688 C  CD2 . TRP A 1 574 ? -46.454 19.193 40.369 1 36.903  ? 592  TRP A CD2 1 
ATOM   4689 N  NE1 . TRP A 1 574 ? -48.252 17.864 40.379 1 42.574  ? 592  TRP A NE1 1 
ATOM   4690 C  CE2 . TRP A 1 574 ? -47.417 18.574 41.195 1 37.587  ? 592  TRP A CE2 1 
ATOM   4691 C  CE3 . TRP A 1 574 ? -45.48  19.995 40.963 1 38.154  ? 592  TRP A CE3 1 
ATOM   4692 C  CZ2 . TRP A 1 574 ? -47.425 18.716 42.579 1 36.047  ? 592  TRP A CZ2 1 
ATOM   4693 C  CZ3 . TRP A 1 574 ? -45.479 20.129 42.337 1 38.059  ? 592  TRP A CZ3 1 
ATOM   4694 C  CH2 . TRP A 1 574 ? -46.44  19.502 43.13  1 36.309  ? 592  TRP A CH2 1 
ATOM   4695 N  N   . LEU A 1 575 ? -45.692 22.31  38.4   1 39.269  ? 593  LEU A N   1 
ATOM   4696 C  CA  . LEU A 1 575 ? -45.566 23.183 39.549 1 35.648  ? 593  LEU A CA  1 
ATOM   4697 C  C   . LEU A 1 575 ? -46.395 24.441 39.323 1 33.513  ? 593  LEU A C   1 
ATOM   4698 O  O   . LEU A 1 575 ? -47.027 24.952 40.244 1 33.291  ? 593  LEU A O   1 
ATOM   4699 C  CB  . LEU A 1 575 ? -44.084 23.485 39.738 1 37.312  ? 593  LEU A CB  1 
ATOM   4700 C  CG  . LEU A 1 575 ? -43.716 24.386 40.915 1 35.457  ? 593  LEU A CG  1 
ATOM   4701 C  CD1 . LEU A 1 575 ? -44.108 23.761 42.233 1 40.431  ? 593  LEU A CD1 1 
ATOM   4702 C  CD2 . LEU A 1 575 ? -42.233 24.652 40.849 1 36.005  ? 593  LEU A CD2 1 
ATOM   4703 N  N   . GLU A 1 576 ? -46.362 24.946 38.093 1 31.88   ? 594  GLU A N   1 
ATOM   4704 C  CA  . GLU A 1 576 ? -47.216 26.054 37.709 1 36.958  ? 594  GLU A CA  1 
ATOM   4705 C  C   . GLU A 1 576 ? -48.669 25.745 38.067 1 40.698  ? 594  GLU A C   1 
ATOM   4706 O  O   . GLU A 1 576 ? -49.317 26.546 38.741 1 41.558  ? 594  GLU A O   1 
ATOM   4707 C  CB  . GLU A 1 576 ? -47.052 26.397 36.233 1 37.975  ? 594  GLU A CB  1 
ATOM   4708 C  CG  . GLU A 1 576 ? -45.742 27.134 35.954 1 42.733  ? 594  GLU A CG  1 
ATOM   4709 C  CD  . GLU A 1 576 ? -45.622 27.795 34.58  1 46.216  ? 594  GLU A CD  1 
ATOM   4710 O  OE1 . GLU A 1 576 ? -46.637 27.857 33.842 1 54.015  ? 594  GLU A OE1 1 
ATOM   4711 O  OE2 . GLU A 1 576 ? -44.504 28.262 34.241 1 44.938  ? 594  GLU A OE2 1 
ATOM   4712 N  N   . ALA A 1 577 ? -49.148 24.565 37.652 1 39.361  ? 595  ALA A N   1 
ATOM   4713 C  CA  . ALA A 1 577 ? -50.509 24.129 37.925 1 38.565  ? 595  ALA A CA  1 
ATOM   4714 C  C   . ALA A 1 577 ? -50.738 24.047 39.43  1 37.498  ? 595  ALA A C   1 
ATOM   4715 O  O   . ALA A 1 577 ? -51.776 24.475 39.923 1 39.525  ? 595  ALA A O   1 
ATOM   4716 C  CB  . ALA A 1 577 ? -50.777 22.779 37.277 1 40.538  ? 595  ALA A CB  1 
ATOM   4717 N  N   . GLU A 1 578 ? -49.792 23.445 40.152 1 34.859  ? 596  GLU A N   1 
ATOM   4718 C  CA  . GLU A 1 578 ? -49.997 23.206 41.576 1 38.022  ? 596  GLU A CA  1 
ATOM   4719 C  C   . GLU A 1 578 ? -50.046 24.526 42.353 1 36.874  ? 596  GLU A C   1 
ATOM   4720 O  O   . GLU A 1 578 ? -50.78  24.637 43.324 1 36.28   ? 596  GLU A O   1 
ATOM   4721 C  CB  . GLU A 1 578 ? -48.881 22.356 42.182 1 40.091  ? 596  GLU A CB  1 
ATOM   4722 C  CG  . GLU A 1 578 ? -49.221 21.804 43.564 1 43.667  ? 596  GLU A CG  1 
ATOM   4723 C  CD  . GLU A 1 578 ? -50.228 20.659 43.632 1 48.325  ? 596  GLU A CD  1 
ATOM   4724 O  OE1 . GLU A 1 578 ? -50.546 20.034 42.585 1 46.948  ? 596  GLU A OE1 1 
ATOM   4725 O  OE2 . GLU A 1 578 ? -50.675 20.381 44.775 1 50.56   ? 596  GLU A OE2 1 
ATOM   4726 N  N   . ASN A 1 579 ? -49.223 25.505 41.954 1 33.532  ? 597  ASN A N   1 
ATOM   4727 C  CA  . ASN A 1 579 ? -49.221 26.808 42.584 1 36.826  ? 597  ASN A CA  1 
ATOM   4728 C  C   . ASN A 1 579 ? -50.563 27.518 42.358 1 35.349  ? 597  ASN A C   1 
ATOM   4729 O  O   . ASN A 1 579 ? -51.073 28.128 43.277 1 36.733  ? 597  ASN A O   1 
ATOM   4730 C  CB  . ASN A 1 579 ? -48.032 27.645 42.117 1 35.391  ? 597  ASN A CB  1 
ATOM   4731 C  CG  . ASN A 1 579 ? -46.751 27.291 42.839 1 35.231  ? 597  ASN A CG  1 
ATOM   4732 O  OD1 . ASN A 1 579 ? -46.757 26.732 43.946 1 32.455  ? 597  ASN A OD1 1 
ATOM   4733 N  ND2 . ASN A 1 579 ? -45.63  27.645 42.232 1 38.127  ? 597  ASN A ND2 1 
ATOM   4734 N  N   . ILE A 1 580 ? -51.099 27.479 41.136 1 36.756  ? 598  ILE A N   1 
ATOM   4735 C  CA  . ILE A 1 580 ? -52.387 28.078 40.799 1 39.637  ? 598  ILE A CA  1 
ATOM   4736 C  C   . ILE A 1 580 ? -53.508 27.392 41.579 1 38.207  ? 598  ILE A C   1 
ATOM   4737 O  O   . ILE A 1 580 ? -54.312 28.054 42.207 1 38.543  ? 598  ILE A O   1 
ATOM   4738 C  CB  . ILE A 1 580 ? -52.63  28.018 39.278 1 42.815  ? 598  ILE A CB  1 
ATOM   4739 C  CG1 . ILE A 1 580 ? -51.776 29.057 38.55  1 39.096  ? 598  ILE A CG1 1 
ATOM   4740 C  CG2 . ILE A 1 580 ? -54.113 28.183 38.926 1 43.365  ? 598  ILE A CG2 1 
ATOM   4741 C  CD1 . ILE A 1 580 ? -51.73  28.845 37.047 1 40.524  ? 598  ILE A CD1 1 
ATOM   4742 N  N   . LYS A 1 581 ? -53.495 26.066 41.607 1 38.073  ? 599  LYS A N   1 
ATOM   4743 C  CA  . LYS A 1 581 ? -54.514 25.289 42.29  1 41.723  ? 599  LYS A CA  1 
ATOM   4744 C  C   . LYS A 1 581 ? -54.534 25.559 43.79  1 37.51   ? 599  LYS A C   1 
ATOM   4745 O  O   . LYS A 1 581 ? -55.571 25.393 44.404 1 38.206  ? 599  LYS A O   1 
ATOM   4746 C  CB  . LYS A 1 581 ? -54.296 23.82  41.913 1 46.841  ? 599  LYS A CB  1 
ATOM   4747 C  CG  . LYS A 1 581 ? -54.88  22.745 42.812 1 57.505  ? 599  LYS A CG  1 
ATOM   4748 C  CD  . LYS A 1 581 ? -54.416 21.364 42.359 1 64.925  ? 599  LYS A CD  1 
ATOM   4749 C  CE  . LYS A 1 581 ? -54.73  21.167 40.892 1 74.339  ? 599  LYS A CE  1 
ATOM   4750 N  NZ  . LYS A 1 581 ? -53.88  20.149 40.277 1 77.074  ? 599  LYS A NZ  1 
ATOM   4751 N  N   . ASN A 1 582 ? -53.401 25.925 44.391 1 37.109  ? 600  ASN A N   1 
ATOM   4752 C  CA  . ASN A 1 582 ? -53.339 26.185 45.825 1 34.388  ? 600  ASN A CA  1 
ATOM   4753 C  C   . ASN A 1 582 ? -53.188 27.682 46.099 1 34.097  ? 600  ASN A C   1 
ATOM   4754 O  O   . ASN A 1 582 ? -52.897 28.091 47.226 1 34.147  ? 600  ASN A O   1 
ATOM   4755 C  CB  . ASN A 1 582 ? -52.164 25.485 46.495 1 36.327  ? 600  ASN A CB  1 
ATOM   4756 C  CG  . ASN A 1 582 ? -52.327 23.989 46.625 1 38.725  ? 600  ASN A CG  1 
ATOM   4757 O  OD1 . ASN A 1 582 ? -52.703 23.498 47.695 1 36.991  ? 600  ASN A OD1 1 
ATOM   4758 N  ND2 . ASN A 1 582 ? -52.009 23.245 45.577 1 38.798  ? 600  ASN A ND2 1 
ATOM   4759 N  N   . ASN A 1 583 ? -53.366 28.506 45.062 1 34.163  ? 601  ASN A N   1 
ATOM   4760 C  CA  . ASN A 1 583 ? -53.461 29.939 45.253 1 40.159  ? 601  ASN A CA  1 
ATOM   4761 C  C   . ASN A 1 583 ? -52.209 30.441 45.976 1 38.733  ? 601  ASN A C   1 
ATOM   4762 O  O   . ASN A 1 583 ? -52.281 31.239 46.897 1 41.568  ? 601  ASN A O   1 
ATOM   4763 C  CB  . ASN A 1 583 ? -54.781 30.247 45.942 1 47.35   ? 601  ASN A CB  1 
ATOM   4764 C  CG  . ASN A 1 583 ? -55.191 31.678 45.701 1 64.587  ? 601  ASN A CG  1 
ATOM   4765 O  OD1 . ASN A 1 583 ? -54.958 32.231 44.617 1 66.622  ? 601  ASN A OD1 1 
ATOM   4766 N  ND2 . ASN A 1 583 ? -55.773 32.306 46.713 1 79.716  ? 601  ASN A ND2 1 
ATOM   4767 N  N   . VAL A 1 584 ? -51.044 29.975 45.528 1 37.008  ? 602  VAL A N   1 
ATOM   4768 C  CA  . VAL A 1 584 ? -49.785 30.244 46.199 1 36.12   ? 602  VAL A CA  1 
ATOM   4769 C  C   . VAL A 1 584 ? -49.287 31.619 45.776 1 33.161  ? 602  VAL A C   1 
ATOM   4770 O  O   . VAL A 1 584 ? -49.238 31.917 44.58  1 31.81   ? 602  VAL A O   1 
ATOM   4771 C  CB  . VAL A 1 584 ? -48.77  29.149 45.827 1 33.527  ? 602  VAL A CB  1 
ATOM   4772 C  CG1 . VAL A 1 584 ? -47.37  29.495 46.297 1 31.94   ? 602  VAL A CG1 1 
ATOM   4773 C  CG2 . VAL A 1 584 ? -49.204 27.795 46.361 1 32.165  ? 602  VAL A CG2 1 
ATOM   4774 N  N   . HIS A 1 585 ? -48.893 32.435 46.768 1 30.674  ? 603  HIS A N   1 
ATOM   4775 C  CA  . HIS A 1 585 ? -48.311 33.74  46.494 1 28.825  ? 603  HIS A CA  1 
ATOM   4776 C  C   . HIS A 1 585 ? -46.892 33.537 45.964 1 30.741  ? 603  HIS A C   1 
ATOM   4777 O  O   . HIS A 1 585 ? -46.122 32.739 46.52  1 28.798  ? 603  HIS A O   1 
ATOM   4778 C  CB  . HIS A 1 585 ? -48.391 34.646 47.73  1 30.423  ? 603  HIS A CB  1 
ATOM   4779 C  CG  . HIS A 1 585 ? -47.862 36.01  47.491 1 34.005  ? 603  HIS A CG  1 
ATOM   4780 N  ND1 . HIS A 1 585 ? -48.628 37.041 47.004 1 34.264  ? 603  HIS A ND1 1 
ATOM   4781 C  CD2 . HIS A 1 585 ? -46.612 36.502 47.602 1 38.094  ? 603  HIS A CD2 1 
ATOM   4782 C  CE1 . HIS A 1 585 ? -47.873 38.119 46.874 1 34.862  ? 603  HIS A CE1 1 
ATOM   4783 N  NE2 . HIS A 1 585 ? -46.643 37.816 47.23  1 35.305  ? 603  HIS A NE2 1 
ATOM   4784 N  N   . ILE A 1 586 ? -46.609 34.248 44.862 1 30.049  ? 604  ILE A N   1 
ATOM   4785 C  CA  . ILE A 1 586 ? -45.333 34.237 44.176 1 32.029  ? 604  ILE A CA  1 
ATOM   4786 C  C   . ILE A 1 586 ? -44.741 35.633 44.283 1 32.661  ? 604  ILE A C   1 
ATOM   4787 O  O   . ILE A 1 586 ? -45.47  36.58  44.02  1 35.395  ? 604  ILE A O   1 
ATOM   4788 C  CB  . ILE A 1 586 ? -45.533 33.868 42.696 1 34.442  ? 604  ILE A CB  1 
ATOM   4789 C  CG1 . ILE A 1 586 ? -46.277 32.544 42.526 1 36.88   ? 604  ILE A CG1 1 
ATOM   4790 C  CG2 . ILE A 1 586 ? -44.2   33.854 41.954 1 36.175  ? 604  ILE A CG2 1 
ATOM   4791 C  CD1 . ILE A 1 586 ? -45.566 31.37  43.173 1 39.313  ? 604  ILE A CD1 1 
ATOM   4792 N  N   . GLY A 1 587 ? -43.426 35.733 44.58  1 28.524  ? 605  GLY A N   1 
ATOM   4793 C  CA  . GLY A 1 587 ? -42.734 37.009 44.731 1 25.495  ? 605  GLY A CA  1 
ATOM   4794 C  C   . GLY A 1 587 ? -42.601 37.394 46.217 1 26.244  ? 605  GLY A C   1 
ATOM   4795 O  O   . GLY A 1 587 ? -43.06  36.669 47.1   1 26.9    ? 605  GLY A O   1 
ATOM   4796 N  N   . TRP A 1 588 ? -41.921 38.507 46.509 1 26.926  ? 606  TRP A N   1 
ATOM   4797 C  CA  . TRP A 1 588 ? -41.646 38.868 47.889 1 28.254  ? 606  TRP A CA  1 
ATOM   4798 C  C   . TRP A 1 588 ? -41.415 40.362 48.002 1 28.32   ? 606  TRP A C   1 
ATOM   4799 O  O   . TRP A 1 588 ? -40.881 40.987 47.083 1 31.275  ? 606  TRP A O   1 
ATOM   4800 C  CB  . TRP A 1 588 ? -40.458 38.079 48.466 1 29.924  ? 606  TRP A CB  1 
ATOM   4801 C  CG  . TRP A 1 588 ? -39.21  38.193 47.633 1 28.722  ? 606  TRP A CG  1 
ATOM   4802 C  CD1 . TRP A 1 588 ? -38.235 39.142 47.717 1 28.666  ? 606  TRP A CD1 1 
ATOM   4803 C  CD2 . TRP A 1 588 ? -38.8   37.292 46.589 1 26.523  ? 606  TRP A CD2 1 
ATOM   4804 N  NE1 . TRP A 1 588 ? -37.272 38.924 46.769 1 26.706  ? 606  TRP A NE1 1 
ATOM   4805 C  CE2 . TRP A 1 588 ? -37.583 37.788 46.071 1 28.247  ? 606  TRP A CE2 1 
ATOM   4806 C  CE3 . TRP A 1 588 ? -39.324 36.115 46.065 1 26.162  ? 606  TRP A CE3 1 
ATOM   4807 C  CZ2 . TRP A 1 588 ? -36.889 37.136 45.053 1 27.88   ? 606  TRP A CZ2 1 
ATOM   4808 C  CZ3 . TRP A 1 588 ? -38.636 35.469 45.059 1 26.629  ? 606  TRP A CZ3 1 
ATOM   4809 C  CH2 . TRP A 1 588 ? -37.436 35.969 44.566 1 26.867  ? 606  TRP A CH2 1 
ATOM   4810 N  N   . THR A 1 589 ? -41.844 40.892 49.155 1 30.474  ? 607  THR A N   1 
ATOM   4811 C  CA  . THR A 1 589 ? -41.571 42.264 49.561 1 32.945  ? 607  THR A CA  1 
ATOM   4812 C  C   . THR A 1 589 ? -40.086 42.402 49.909 1 35.425  ? 607  THR A C   1 
ATOM   4813 O  O   . THR A 1 589 ? -39.428 41.404 50.208 1 31.161  ? 607  THR A O   1 
ATOM   4814 C  CB  . THR A 1 589 ? -42.431 42.597 50.782 1 34.356  ? 607  THR A CB  1 
ATOM   4815 O  OG1 . THR A 1 589 ? -42.149 41.635 51.799 1 34.765  ? 607  THR A OG1 1 
ATOM   4816 C  CG2 . THR A 1 589 ? -43.92  42.539 50.503 1 36.132  ? 607  THR A CG2 1 
ATOM   4817 N  N   . THR A 1 590 ? -39.591 43.65  49.922 1 35.671  ? 608  THR A N   1 
ATOM   4818 C  CA  . THR A 1 590 ? -38.227 43.957 50.325 1 36.576  ? 608  THR A CA  1 
ATOM   4819 C  C   . THR A 1 590 ? -38.022 43.581 51.792 1 34.978  ? 608  THR A C   1 
ATOM   4820 O  O   . THR A 1 590 ? -38.901 43.775 52.637 1 33.517  ? 608  THR A O   1 
ATOM   4821 C  CB  . THR A 1 590 ? -37.914 45.426 50.044 1 40.147  ? 608  THR A CB  1 
ATOM   4822 O  OG1 . THR A 1 590 ? -38.021 45.542 48.626 1 38.495  ? 608  THR A OG1 1 
ATOM   4823 C  CG2 . THR A 1 590 ? -36.487 45.814 50.402 1 42.009  ? 608  THR A CG2 1 
ATOM   4824 N  N   . SER A 1 591 ? -36.888 42.923 52.051 1 31.049  ? 609  SER A N   1 
ATOM   4825 C  CA  . SER A 1 591 ? -36.539 42.473 53.387 1 31.838  ? 609  SER A CA  1 
ATOM   4826 C  C   . SER A 1 591 ? -36.346 43.678 54.296 1 33.032  ? 609  SER A C   1 
ATOM   4827 O  O   . SER A 1 591 ? -35.838 44.705 53.868 1 28.004  ? 609  SER A O   1 
ATOM   4828 C  CB  . SER A 1 591 ? -35.264 41.681 53.339 1 32.131  ? 609  SER A CB  1 
ATOM   4829 O  OG  . SER A 1 591 ? -34.829 41.328 54.639 1 31.342  ? 609  SER A OG  1 
ATOM   4830 N  N   . ASN A 1 592 ? -36.666 43.55  55.577 1 37.727  ? 610  ASN A N   1 
ATOM   4831 C  CA  . ASN A 1 592 ? -36.237 44.614 56.47  1 45.07   ? 610  ASN A CA  1 
ATOM   4832 C  C   . ASN A 1 592 ? -35.321 44.051 57.56  1 45.429  ? 610  ASN A C   1 
ATOM   4833 O  O   . ASN A 1 592 ? -35.288 44.58  58.668 1 39.318  ? 610  ASN A O   1 
ATOM   4834 C  CB  . ASN A 1 592 ? -37.425 45.467 56.916 1 53.88   ? 610  ASN A CB  1 
ATOM   4835 C  CG  . ASN A 1 592 ? -38.581 44.631 57.401 1 60.718  ? 610  ASN A CG  1 
ATOM   4836 O  OD1 . ASN A 1 592 ? -38.375 43.661 58.155 1 58.981  ? 610  ASN A OD1 1 
ATOM   4837 N  ND2 . ASN A 1 592 ? -39.78  44.978 56.934 1 55.388  ? 610  ASN A ND2 1 
ATOM   4838 N  N   . LYS A 1 593 ? -34.517 43.036 57.195 1 38.781  ? 611  LYS A N   1 
ATOM   4839 C  CA  . LYS A 1 593 ? -33.585 42.411 58.113 1 37.184  ? 611  LYS A CA  1 
ATOM   4840 C  C   . LYS A 1 593 ? -32.179 43.007 58.006 1 38.508  ? 611  LYS A C   1 
ATOM   4841 O  O   . LYS A 1 593 ? -31.27  42.467 58.629 1 41.101  ? 611  LYS A O   1 
ATOM   4842 C  CB  . LYS A 1 593 ? -33.566 40.901 57.862 1 37.887  ? 611  LYS A CB  1 
ATOM   4843 C  CG  . LYS A 1 593 ? -34.766 40.16  58.427 1 40.051  ? 611  LYS A CG  1 
ATOM   4844 C  CD  . LYS A 1 593 ? -34.84  40.283 59.944 1 44.298  ? 611  LYS A CD  1 
ATOM   4845 C  CE  . LYS A 1 593 ? -35.926 39.491 60.574 1 47.642  ? 611  LYS A CE  1 
ATOM   4846 N  NZ  . LYS A 1 593 ? -37.121 39.635 59.75  1 49.114  ? 611  LYS A NZ  1 
ATOM   4847 N  N   . CYS A 1 594 ? -31.967 44.093 57.237 1 36.253  ? 612  CYS A N   1 
ATOM   4848 C  CA  . CYS A 1 594 ? -30.651 44.729 57.239 1 41.175  ? 612  CYS A CA  1 
ATOM   4849 C  C   . CYS A 1 594 ? -30.832 46.242 57.343 1 39.747  ? 612  CYS A C   1 
ATOM   4850 O  O   . CYS A 1 594 ? -31.294 46.875 56.402 1 39.173  ? 612  CYS A O   1 
ATOM   4851 C  CB  . CYS A 1 594 ? -29.761 44.3   56.071 1 41.818  ? 612  CYS A CB  1 
ATOM   4852 S  SG  . CYS A 1 594 ? -27.991 44.644 56.319 1 48.731  ? 612  CYS A SG  1 
ATOM   4853 N  N   . VAL A 1 595 ? -30.455 46.78  58.511 1 43.132  ? 613  VAL A N   1 
ATOM   4854 C  CA  . VAL A 1 595 ? -30.625 48.176 58.895 1 49.332  ? 613  VAL A CA  1 
ATOM   4855 C  C   . VAL A 1 595 ? -29.381 48.974 58.51  1 49.692  ? 613  VAL A C   1 
ATOM   4856 O  O   . VAL A 1 595 ? -28.294 48.641 58.958 1 56.484  ? 613  VAL A O   1 
ATOM   4857 C  CB  . VAL A 1 595 ? -30.837 48.23  60.425 1 51.938  ? 613  VAL A CB  1 
ATOM   4858 C  CG1 . VAL A 1 595 ? -30.635 49.635 60.977 1 64.535  ? 613  VAL A CG1 1 
ATOM   4859 C  CG2 . VAL A 1 595 ? -32.196 47.684 60.853 1 50.072  ? 613  VAL A CG2 1 
ATOM   4860 N  N   . SER A 1 596 ? -29.537 50.021 57.692 1 64.207  ? 614  SER A N   1 
ATOM   4861 C  CA  . SER A 1 596 ? -28.56  51.107 57.596 1 71.726  ? 614  SER A CA  1 
ATOM   4862 C  C   . SER A 1 596 ? -28.924 52.18  58.636 1 71.244  ? 614  SER A C   1 
ATOM   4863 O  O   . SER A 1 596 ? -28.022 52.585 59.38  1 79.662  ? 614  SER A O   1 
ATOM   4864 C  CB  . SER A 1 596 ? -28.527 51.719 56.21  1 67.95   ? 614  SER A CB  1 
ATOM   4865 O  OG  . SER A 1 596 ? -29.199 50.89  55.267 1 61.53   ? 614  SER A OG  1 
ATOM   4866 N  N   . VAL B 2 1   ? -15.671 21.879 46.276 1 49.462  ? 1701 VAL B N   1 
ATOM   4867 C  CA  . VAL B 2 1   ? -17.152 21.837 46.074 1 42.764  ? 1701 VAL B CA  1 
ATOM   4868 C  C   . VAL B 2 1   ? -17.725 23.249 46.286 1 41.131  ? 1701 VAL B C   1 
ATOM   4869 O  O   . VAL B 2 1   ? -17.052 24.122 46.86  1 32.806  ? 1701 VAL B O   1 
ATOM   4870 C  CB  . VAL B 2 1   ? -17.702 20.781 47.056 1 40.965  ? 1701 VAL B CB  1 
ATOM   4871 C  CG1 . VAL B 2 1   ? -17.531 21.221 48.504 1 38.829  ? 1701 VAL B CG1 1 
ATOM   4872 C  CG2 . VAL B 2 1   ? -19.15  20.369 46.768 1 41.796  ? 1701 VAL B CG2 1 
ATOM   4873 N  N   . TRP B 2 2   ? -18.96  23.474 45.802 1 34.434  ? 1702 TRP B N   1 
ATOM   4874 C  CA  . TRP B 2 2   ? -19.657 24.747 45.976 1 35.452  ? 1702 TRP B CA  1 
ATOM   4875 C  C   . TRP B 2 2   ? -19.889 25.083 47.463 1 36.921  ? 1702 TRP B C   1 
ATOM   4876 O  O   . TRP B 2 2   ? -19.74  24.186 48.326 1 33.891  ? 1702 TRP B O   1 
ATOM   4877 C  CB  . TRP B 2 2   ? -20.99  24.721 45.234 1 37.281  ? 1702 TRP B CB  1 
ATOM   4878 C  CG  . TRP B 2 2   ? -21.806 23.496 45.535 1 40.941  ? 1702 TRP B CG  1 
ATOM   4879 C  CD1 . TRP B 2 2   ? -22.624 23.312 46.604 1 48.108  ? 1702 TRP B CD1 1 
ATOM   4880 C  CD2 . TRP B 2 2   ? -21.869 22.279 44.763 1 47.292  ? 1702 TRP B CD2 1 
ATOM   4881 N  NE1 . TRP B 2 2   ? -23.189 22.068 46.561 1 56.255  ? 1702 TRP B NE1 1 
ATOM   4882 C  CE2 . TRP B 2 2   ? -22.751 21.411 45.445 1 58.363  ? 1702 TRP B CE2 1 
ATOM   4883 C  CE3 . TRP B 2 2   ? -21.274 21.841 43.572 1 52.388  ? 1702 TRP B CE3 1 
ATOM   4884 C  CZ2 . TRP B 2 2   ? -23.056 20.135 44.977 1 63.103  ? 1702 TRP B CZ2 1 
ATOM   4885 C  CZ3 . TRP B 2 2   ? -21.585 20.587 43.1   1 57.996  ? 1702 TRP B CZ3 1 
ATOM   4886 C  CH2 . TRP B 2 2   ? -22.456 19.745 43.8   1 67.034  ? 1702 TRP B CH2 1 
ATOM   4887 O  OXT . TRP B 2 2   ? -20.228 26.268 47.712 1 39.061  ? 1702 TRP B OXT 1 
ATOM   4888 N  N   . VAL C 2 1   ? -5.599  24.355 43.546 1 57.376  ? 1629 VAL D N   1 
ATOM   4889 C  CA  . VAL C 2 1   ? -6.733  23.647 44.215 1 62.477  ? 1629 VAL D CA  1 
ATOM   4890 C  C   . VAL C 2 1   ? -8.055  23.964 43.487 1 64.431  ? 1629 VAL D C   1 
ATOM   4891 O  O   . VAL C 2 1   ? -8.234  25.043 42.906 1 51.791  ? 1629 VAL D O   1 
ATOM   4892 C  CB  . VAL C 2 1   ? -6.696  24.03  45.717 1 75.624  ? 1629 VAL D CB  1 
ATOM   4893 C  CG1 . VAL C 2 1   ? -6.638  25.542 45.977 1 80.291  ? 1629 VAL D CG1 1 
ATOM   4894 C  CG2 . VAL C 2 1   ? -7.829  23.396 46.51  1 74.821  ? 1629 VAL D CG2 1 
ATOM   4895 N  N   . TRP C 2 2   ? -8.979  22.986 43.473 1 58.185  ? 1630 TRP D N   1 
ATOM   4896 C  CA  . TRP C 2 2   ? -10.309 23.164 42.901 1 52.817  ? 1630 TRP D CA  1 
ATOM   4897 C  C   . TRP C 2 2   ? -11.406 22.767 43.909 1 50.062  ? 1630 TRP D C   1 
ATOM   4898 O  O   . TRP C 2 2   ? -11.372 21.629 44.42  1 48.478  ? 1630 TRP D O   1 
ATOM   4899 C  CB  . TRP C 2 2   ? -10.439 22.399 41.575 1 48.335  ? 1630 TRP D CB  1 
ATOM   4900 C  CG  . TRP C 2 2   ? -9.704  23.058 40.441 1 47.062  ? 1630 TRP D CG  1 
ATOM   4901 C  CD1 . TRP C 2 2   ? -8.392  22.869 40.123 1 48.825  ? 1630 TRP D CD1 1 
ATOM   4902 C  CD2 . TRP C 2 2   ? -10.203 24.041 39.505 1 46.514  ? 1630 TRP D CD2 1 
ATOM   4903 N  NE1 . TRP C 2 2   ? -8.055  23.618 39.029 1 45.675  ? 1630 TRP D NE1 1 
ATOM   4904 C  CE2 . TRP C 2 2   ? -9.134  24.36  38.634 1 48.199  ? 1630 TRP D CE2 1 
ATOM   4905 C  CE3 . TRP C 2 2   ? -11.431 24.687 39.309 1 53.454  ? 1630 TRP D CE3 1 
ATOM   4906 C  CZ2 . TRP C 2 2   ? -9.257  25.29  37.598 1 55.053  ? 1630 TRP D CZ2 1 
ATOM   4907 C  CZ3 . TRP C 2 2   ? -11.556 25.613 38.288 1 56.307  ? 1630 TRP D CZ3 1 
ATOM   4908 C  CH2 . TRP C 2 2   ? -10.476 25.912 37.442 1 58.006  ? 1630 TRP D CH2 1 
ATOM   4909 O  OXT . TRP C 2 2   ? -12.293 23.617 44.131 1 51.709  ? 1630 TRP D OXT 1 
HETATM 4910 C  C1  . NAG D 3 .   ? -0.389  48.656 31.146 1 40.403  ? 1    NAG C C1  1 
HETATM 4911 C  C2  . NAG D 3 .   ? 0.779   47.832 30.619 1 39.932  ? 1    NAG C C2  1 
HETATM 4912 C  C3  . NAG D 3 .   ? 2.071   48.653 30.6   1 38.303  ? 1    NAG C C3  1 
HETATM 4913 C  C4  . NAG D 3 .   ? 1.857   50.067 30.072 1 40.763  ? 1    NAG C C4  1 
HETATM 4914 C  C5  . NAG D 3 .   ? 0.606   50.741 30.635 1 39.597  ? 1    NAG C C5  1 
HETATM 4915 C  C6  . NAG D 3 .   ? 0.274   52.067 29.971 1 37.26   ? 1    NAG C C6  1 
HETATM 4916 C  C7  . NAG D 3 .   ? 0.719   45.371 30.932 1 43.486  ? 1    NAG C C7  1 
HETATM 4917 C  C8  . NAG D 3 .   ? 0.851   44.247 31.929 1 39.439  ? 1    NAG C C8  1 
HETATM 4918 N  N2  . NAG D 3 .   ? 0.877   46.617 31.406 1 42.1    ? 1    NAG C N2  1 
HETATM 4919 O  O3  . NAG D 3 .   ? 2.986   47.978 29.744 1 39.91   ? 1    NAG C O3  1 
HETATM 4920 O  O4  . NAG D 3 .   ? 2.995   50.863 30.401 1 45.406  ? 1    NAG C O4  1 
HETATM 4921 O  O5  . NAG D 3 .   ? -0.515  49.869 30.41  1 35.864  ? 1    NAG C O5  1 
HETATM 4922 O  O6  . NAG D 3 .   ? -0.856  52.714 30.584 1 40.394  ? 1    NAG C O6  1 
HETATM 4923 O  O7  . NAG D 3 .   ? 0.531   45.163 29.737 1 46.998  ? 1    NAG C O7  1 
HETATM 4924 C  C1  . NAG D 3 .   ? 3.743   51.26  29.288 1 47.342  ? 2    NAG C C1  1 
HETATM 4925 C  C2  . NAG D 3 .   ? 4.789   52.232 29.804 1 52.8    ? 2    NAG C C2  1 
HETATM 4926 C  C3  . NAG D 3 .   ? 5.665   52.677 28.634 1 52.604  ? 2    NAG C C3  1 
HETATM 4927 C  C4  . NAG D 3 .   ? 6.309   51.461 27.976 1 55.002  ? 2    NAG C C4  1 
HETATM 4928 C  C5  . NAG D 3 .   ? 5.221   50.494 27.514 1 55.312  ? 2    NAG C C5  1 
HETATM 4929 C  C6  . NAG D 3 .   ? 5.754   49.189 26.963 1 51.745  ? 2    NAG C C6  1 
HETATM 4930 C  C7  . NAG D 3 .   ? 3.404   54.242 30.214 1 61.816  ? 2    NAG C C7  1 
HETATM 4931 C  C8  . NAG D 3 .   ? 2.522   54.864 31.264 1 53.093  ? 2    NAG C C8  1 
HETATM 4932 N  N2  . NAG D 3 .   ? 4.201   53.265 30.645 1 49.804  ? 2    NAG C N2  1 
HETATM 4933 O  O3  . NAG D 3 .   ? 6.655   53.571 29.113 1 59.719  ? 2    NAG C O3  1 
HETATM 4934 O  O4  . NAG D 3 .   ? 7.064   51.854 26.831 1 65.183  ? 2    NAG C O4  1 
HETATM 4935 O  O5  . NAG D 3 .   ? 4.368   50.158 28.629 1 47.07   ? 2    NAG C O5  1 
HETATM 4936 O  O6  . NAG D 3 .   ? 4.818   48.129 27.25  1 70.945  ? 2    NAG C O6  1 
HETATM 4937 O  O7  . NAG D 3 .   ? 3.408   54.603 29.031 1 60.717  ? 2    NAG C O7  1 
HETATM 4938 C  C1  . BMA D 3 .   ? 8.347   52.394 26.912 1 78.865  ? 3    BMA C C1  1 
HETATM 4939 C  C2  . BMA D 3 .   ? 8.959   52.055 25.563 1 80.81   ? 3    BMA C C2  1 
HETATM 4940 C  C3  . BMA D 3 .   ? 10.397  52.503 25.489 1 87.351  ? 3    BMA C C3  1 
HETATM 4941 C  C4  . BMA D 3 .   ? 10.595  53.93  25.985 1 89.741  ? 3    BMA C C4  1 
HETATM 4942 C  C5  . BMA D 3 .   ? 9.802   54.267 27.267 1 94.008  ? 3    BMA C C5  1 
HETATM 4943 C  C6  . BMA D 3 .   ? 9.796   55.763 27.581 1 90.949  ? 3    BMA C C6  1 
HETATM 4944 O  O2  . BMA D 3 .   ? 8.201   52.657 24.512 1 63.297  ? 3    BMA C O2  1 
HETATM 4945 O  O3  . BMA D 3 .   ? 10.798  52.45  24.117 1 94.183  ? 3    BMA C O3  1 
HETATM 4946 O  O4  . BMA D 3 .   ? 11.978  54.08  26.248 1 92.61   ? 3    BMA C O4  1 
HETATM 4947 O  O5  . BMA D 3 .   ? 8.427   53.81  27.113 1 90.193  ? 3    BMA C O5  1 
HETATM 4948 O  O6  . BMA D 3 .   ? 8.72    56.182 28.47  1 95.631  ? 3    BMA C O6  1 
HETATM 4949 C  C1  . MAN D 3 .   ? 11.746  51.497 23.761 1 94.719  ? 4    MAN C C1  1 
HETATM 4950 C  C2  . MAN D 3 .   ? 12.394  51.959 22.457 1 98.902  ? 4    MAN C C2  1 
HETATM 4951 C  C3  . MAN D 3 .   ? 12.853  50.782 21.671 1 92.68   ? 4    MAN C C3  1 
HETATM 4952 C  C4  . MAN D 3 .   ? 11.607  50.016 21.203 1 95.645  ? 4    MAN C C4  1 
HETATM 4953 C  C5  . MAN D 3 .   ? 10.5    50.015 22.302 1 86.35   ? 4    MAN C C5  1 
HETATM 4954 C  C6  . MAN D 3 .   ? 9.735   48.709 22.383 1 83.409  ? 4    MAN C C6  1 
HETATM 4955 O  O2  . MAN D 3 .   ? 13.501  52.823 22.685 1 121.078 ? 4    MAN C O2  1 
HETATM 4956 O  O3  . MAN D 3 .   ? 13.747  50.013 22.502 1 69.406  ? 4    MAN C O3  1 
HETATM 4957 O  O4  . MAN D 3 .   ? 11.079  50.613 20     1 74.904  ? 4    MAN C O4  1 
HETATM 4958 O  O5  . MAN D 3 .   ? 11.101  50.231 23.606 1 90.151  ? 4    MAN C O5  1 
HETATM 4959 O  O6  . MAN D 3 .   ? 9.415   48.252 21.053 1 83.505  ? 4    MAN C O6  1 
HETATM 4960 C  C1  . BMA D 3 .   ? 8.723   47.045 20.846 1 91.801  ? 5    BMA C C1  1 
HETATM 4961 C  C2  . BMA D 3 .   ? 7.958   47.252 19.54  1 97.294  ? 5    BMA C C2  1 
HETATM 4962 C  C3  . BMA D 3 .   ? 8.745   46.82  18.323 1 94.139  ? 5    BMA C C3  1 
HETATM 4963 C  C4  . BMA D 3 .   ? 10.231  46.973 18.629 1 94.244  ? 5    BMA C C4  1 
HETATM 4964 C  C5  . BMA D 3 .   ? 10.636  45.976 19.754 1 94.906  ? 5    BMA C C5  1 
HETATM 4965 C  C6  . BMA D 3 .   ? 11.893  46.398 20.499 1 99.989  ? 5    BMA C C6  1 
HETATM 4966 O  O2  . BMA D 3 .   ? 7.619   48.625 19.381 1 111.208 ? 5    BMA C O2  1 
HETATM 4967 O  O3  . BMA D 3 .   ? 8.297   47.578 17.19  1 74.171  ? 5    BMA C O3  1 
HETATM 4968 O  O4  . BMA D 3 .   ? 11.01   46.733 17.474 1 82.357  ? 5    BMA C O4  1 
HETATM 4969 O  O5  . BMA D 3 .   ? 9.561   45.883 20.746 1 85.171  ? 5    BMA C O5  1 
HETATM 4970 O  O6  . BMA D 3 .   ? 12.772  45.316 20.814 1 95.881  ? 5    BMA C O6  1 
HETATM 4971 C  C1  . MAN D 3 .   ? 8.979   56.883 29.652 1 95.683  ? 6    MAN C C1  1 
HETATM 4972 C  C2  . MAN D 3 .   ? 8.691   55.973 30.864 1 101.102 ? 6    MAN C C2  1 
HETATM 4973 C  C3  . MAN D 3 .   ? 7.331   56.293 31.594 1 97.902  ? 6    MAN C C3  1 
HETATM 4974 C  C4  . MAN D 3 .   ? 7.009   57.779 31.518 1 102.336 ? 6    MAN C C4  1 
HETATM 4975 C  C5  . MAN D 3 .   ? 7.073   58.202 30.035 1 107.068 ? 6    MAN C C5  1 
HETATM 4976 C  C6  . MAN D 3 .   ? 6.526   59.575 29.687 1 107.37  ? 6    MAN C C6  1 
HETATM 4977 O  O2  . MAN D 3 .   ? 9.743   56.089 31.82  1 88.689  ? 6    MAN C O2  1 
HETATM 4978 O  O3  . MAN D 3 .   ? 7.304   55.892 32.971 1 77.726  ? 6    MAN C O3  1 
HETATM 4979 O  O4  . MAN D 3 .   ? 5.736   58.011 32.111 1 93.283  ? 6    MAN C O4  1 
HETATM 4980 O  O5  . MAN D 3 .   ? 8.471   58.197 29.701 1 95.481  ? 6    MAN C O5  1 
HETATM 4981 O  O6  . MAN D 3 .   ? 6.71    59.88  28.287 1 87.49   ? 6    MAN C O6  1 
HETATM 4982 ZN ZN  . ZN  E 4 .   ? -15.164 21.67  42.391 1 32.546  ? 701  ZN  A ZN  1 
HETATM 4983 C  C1  . NAG F 5 .   ? -11.53  2.66   25.263 1 94.163  ? 702  NAG A C1  1 
HETATM 4984 C  C2  . NAG F 5 .   ? -12.705 2.058  24.468 1 100.939 ? 702  NAG A C2  1 
HETATM 4985 C  C3  . NAG F 5 .   ? -12.587 2.076  22.933 1 111.211 ? 702  NAG A C3  1 
HETATM 4986 C  C4  . NAG F 5 .   ? -11.43  2.908  22.364 1 119.447 ? 702  NAG A C4  1 
HETATM 4987 C  C5  . NAG F 5 .   ? -10.215 2.719  23.262 1 114.026 ? 702  NAG A C5  1 
HETATM 4988 C  C6  . NAG F 5 .   ? -8.906  3.263  22.697 1 107.684 ? 702  NAG A C6  1 
HETATM 4989 C  C7  . NAG F 5 .   ? -14.041 0.179  25.414 1 103.399 ? 702  NAG A C7  1 
HETATM 4990 C  C8  . NAG F 5 .   ? -13.931 -0.711 26.62  1 83.938  ? 702  NAG A C8  1 
HETATM 4991 N  N2  . NAG F 5 .   ? -12.902 0.688  24.926 1 108.211 ? 702  NAG A N2  1 
HETATM 4992 O  O3  . NAG F 5 .   ? -13.859 2.524  22.476 1 86.433  ? 702  NAG A O3  1 
HETATM 4993 O  O4  . NAG F 5 .   ? -11.078 2.51   21.038 1 116.807 ? 702  NAG A O4  1 
HETATM 4994 O  O5  . NAG F 5 .   ? -10.578 3.399  24.482 1 95.245  ? 702  NAG A O5  1 
HETATM 4995 O  O6  . NAG F 5 .   ? -8.658  4.608  23.077 1 106.798 ? 702  NAG A O6  1 
HETATM 4996 O  O7  . NAG F 5 .   ? -15.121 0.418  24.885 1 101.09  ? 702  NAG A O7  1 
HETATM 4997 C  C1  . NAG G 5 .   ? 1.579   19.776 61.477 1 78.965  ? 703  NAG A C1  1 
HETATM 4998 C  C2  . NAG G 5 .   ? 2.126   18.365 61.691 1 85.469  ? 703  NAG A C2  1 
HETATM 4999 C  C3  . NAG G 5 .   ? 3.371   18.363 62.579 1 89.359  ? 703  NAG A C3  1 
HETATM 5000 C  C4  . NAG G 5 .   ? 4.388   19.398 62.114 1 92.328  ? 703  NAG A C4  1 
HETATM 5001 C  C5  . NAG G 5 .   ? 3.693   20.757 62.12  1 93.635  ? 703  NAG A C5  1 
HETATM 5002 C  C6  . NAG G 5 .   ? 4.572   21.919 61.706 1 89.455  ? 703  NAG A C6  1 
HETATM 5003 C  C7  . NAG G 5 .   ? 0.574   16.45  61.523 1 76.308  ? 703  NAG A C7  1 
HETATM 5004 C  C8  . NAG G 5 .   ? -0.483  15.664 62.246 1 68.852  ? 703  NAG A C8  1 
HETATM 5005 N  N2  . NAG G 5 .   ? 1.111   17.468 62.216 1 80.589  ? 703  NAG A N2  1 
HETATM 5006 O  O3  . NAG G 5 .   ? 3.929   17.061 62.526 1 88.895  ? 703  NAG A O3  1 
HETATM 5007 O  O4  . NAG G 5 .   ? 5.531   19.382 62.971 1 90.398  ? 703  NAG A O4  1 
HETATM 5008 O  O5  . NAG G 5 .   ? 2.611   20.712 61.168 1 85.968  ? 703  NAG A O5  1 
HETATM 5009 O  O6  . NAG G 5 .   ? 4.006   23.161 62.148 1 79.683  ? 703  NAG A O6  1 
HETATM 5010 O  O7  . NAG G 5 .   ? 0.933   16.168 60.375 1 51.415  ? 703  NAG A O7  1 
HETATM 5011 O  O   . HOH H 6 .   ? -1.976  49.73  34.986 1 34.154  ? 801  HOH A O   1 
HETATM 5012 O  O   . HOH H 6 .   ? 7.91    27.192 43.431 1 40.107  ? 802  HOH A O   1 
HETATM 5013 O  O   . HOH H 6 .   ? -29.576 40.624 36.679 1 38.922  ? 803  HOH A O   1 
HETATM 5014 O  O   . HOH H 6 .   ? -14.826 17.913 53.2   1 39.824  ? 804  HOH A O   1 
HETATM 5015 O  O   . HOH H 6 .   ? -4.577  21.275 36.783 1 28.692  ? 805  HOH A O   1 
HETATM 5016 O  O   . HOH H 6 .   ? -2.433  17.946 35.141 1 30.089  ? 806  HOH A O   1 
HETATM 5017 O  O   . HOH H 6 .   ? -7.847  30.422 47.381 1 47.271  ? 807  HOH A O   1 
HETATM 5018 O  O   . HOH H 6 .   ? -9.885  20.208 51.183 1 35.442  ? 808  HOH A O   1 
HETATM 5019 O  O   . HOH H 6 .   ? -40.307 30.733 69.181 1 36.755  ? 809  HOH A O   1 
HETATM 5020 O  O   . HOH H 6 .   ? -26.81  33.5   51.302 1 35.612  ? 810  HOH A O   1 
HETATM 5021 O  O   . HOH H 6 .   ? -26.123 44.501 63.774 1 37.843  ? 811  HOH A O   1 
HETATM 5022 O  O   . HOH H 6 .   ? -21.724 40.105 63.674 1 35.706  ? 812  HOH A O   1 
HETATM 5023 O  O   . HOH H 6 .   ? 7.436   20.745 63.88  1 47.466  ? 813  HOH A O   1 
HETATM 5024 O  O   . HOH H 6 .   ? -36.688 15.414 32.22  1 35.718  ? 814  HOH A O   1 
HETATM 5025 O  O   . HOH H 6 .   ? -16.943 20.92  54.721 1 37.951  ? 815  HOH A O   1 
HETATM 5026 O  O   . HOH H 6 .   ? -53.442 34.814 52.495 1 34.087  ? 816  HOH A O   1 
HETATM 5027 O  O   . HOH H 6 .   ? -22.272 43.34  40.684 1 31.314  ? 817  HOH A O   1 
HETATM 5028 O  O   . HOH H 6 .   ? 4.506   16.048 44.64  1 32.903  ? 818  HOH A O   1 
HETATM 5029 O  O   . HOH H 6 .   ? -14.011 37.322 29.21  1 34.612  ? 819  HOH A O   1 
HETATM 5030 O  O   . HOH H 6 .   ? -25.215 41.444 65.338 1 36.844  ? 820  HOH A O   1 
HETATM 5031 O  O   . HOH H 6 .   ? -10.857 21.034 28.09  1 28.786  ? 821  HOH A O   1 
HETATM 5032 O  O   . HOH H 6 .   ? -20.354 22.165 39.869 1 26.5    ? 822  HOH A O   1 
HETATM 5033 O  O   . HOH H 6 .   ? -13.832 33.616 58.028 1 28.75   ? 823  HOH A O   1 
HETATM 5034 O  O   . HOH H 6 .   ? -30.873 14.706 42.049 1 46.584  ? 824  HOH A O   1 
HETATM 5035 O  O   . HOH H 6 .   ? -48.819 23.992 33.923 1 39.738  ? 825  HOH A O   1 
HETATM 5036 O  O   . HOH H 6 .   ? -11.67  29.834 27.273 1 34.252  ? 826  HOH A O   1 
HETATM 5037 O  O   . HOH H 6 .   ? -2.615  8.294  34.572 1 36.449  ? 827  HOH A O   1 
HETATM 5038 O  O   . HOH H 6 .   ? -30.156 29.884 26.955 1 41.268  ? 828  HOH A O   1 
HETATM 5039 O  O   . HOH H 6 .   ? -36.782 42.601 47.086 1 37.969  ? 829  HOH A O   1 
HETATM 5040 O  O   . HOH H 6 .   ? -30.228 22.111 52.044 1 30.783  ? 830  HOH A O   1 
HETATM 5041 O  O   . HOH H 6 .   ? -13.856 34.244 64.535 1 47.041  ? 831  HOH A O   1 
HETATM 5042 O  O   . HOH H 6 .   ? -34.181 22.343 58.938 1 42.478  ? 832  HOH A O   1 
HETATM 5043 O  O   . HOH H 6 .   ? -24.815 32.308 25.74  1 36.89   ? 833  HOH A O   1 
HETATM 5044 O  O   . HOH H 6 .   ? -7.588  23.121 51.624 1 37.176  ? 834  HOH A O   1 
HETATM 5045 O  O   . HOH H 6 .   ? -25.974 45.278 46.558 1 36.772  ? 835  HOH A O   1 
HETATM 5046 O  O   . HOH H 6 .   ? -12.618 23.89  57.267 1 50.565  ? 836  HOH A O   1 
HETATM 5047 O  O   . HOH H 6 .   ? -9.136  27.316 27.219 1 32.454  ? 837  HOH A O   1 
HETATM 5048 O  O   . HOH H 6 .   ? -13.256 25.752 42.729 1 35.016  ? 838  HOH A O   1 
HETATM 5049 O  O   . HOH H 6 .   ? -39.227 10.001 44.088 1 32.263  ? 839  HOH A O   1 
HETATM 5050 O  O   . HOH H 6 .   ? -7.661  3.195  41.092 1 30.533  ? 840  HOH A O   1 
HETATM 5051 O  O   . HOH H 6 .   ? -30.603 13.008 36.423 1 39.948  ? 841  HOH A O   1 
HETATM 5052 O  O   . HOH H 6 .   ? 5.259   24.626 25.093 1 30.913  ? 842  HOH A O   1 
HETATM 5053 O  O   . HOH H 6 .   ? -23.688 45.215 45.037 1 36.122  ? 843  HOH A O   1 
HETATM 5054 O  O   . HOH H 6 .   ? -19.747 30.744 22.595 1 36.311  ? 844  HOH A O   1 
HETATM 5055 O  O   . HOH H 6 .   ? -25.069 3.9    30.346 1 43.573  ? 845  HOH A O   1 
HETATM 5056 O  O   . HOH H 6 .   ? -36.352 23.628 58.054 1 38.537  ? 846  HOH A O   1 
HETATM 5057 O  O   . HOH H 6 .   ? -15.738 25.611 61.719 1 37.439  ? 847  HOH A O   1 
HETATM 5058 O  O   . HOH H 6 .   ? -6.311  33.543 46.295 1 33.57   ? 848  HOH A O   1 
HETATM 5059 O  O   . HOH H 6 .   ? 6.484   38.864 48.236 1 40.493  ? 849  HOH A O   1 
HETATM 5060 O  O   . HOH H 6 .   ? -8.028  31.331 44.923 1 41.714  ? 850  HOH A O   1 
HETATM 5061 O  O   . HOH H 6 .   ? -35.451 23.815 26.833 1 39.111  ? 851  HOH A O   1 
HETATM 5062 O  O   . HOH H 6 .   ? -27.607 40.422 64.366 1 33.436  ? 852  HOH A O   1 
HETATM 5063 O  O   . HOH H 6 .   ? -33.182 43.971 50.652 1 33.058  ? 853  HOH A O   1 
HETATM 5064 O  O   . HOH H 6 .   ? -35.342 35.924 41.624 1 35.694  ? 854  HOH A O   1 
HETATM 5065 O  O   . HOH H 6 .   ? 3.05    24.808 54.459 1 37.063  ? 855  HOH A O   1 
HETATM 5066 O  O   . HOH H 6 .   ? -21.814 34.689 53.617 1 30.737  ? 856  HOH A O   1 
HETATM 5067 O  O   . HOH H 6 .   ? -32.39  31.463 68.953 1 43.394  ? 857  HOH A O   1 
HETATM 5068 O  O   . HOH H 6 .   ? -21.875 16.739 42.398 1 35.923  ? 858  HOH A O   1 
HETATM 5069 O  O   . HOH H 6 .   ? -10.756 44.63  42.307 1 31.027  ? 859  HOH A O   1 
HETATM 5070 O  O   . HOH H 6 .   ? -50.439 20.378 39.948 1 41.15   ? 860  HOH A O   1 
HETATM 5071 O  O   . HOH H 6 .   ? -36.094 36.338 58.747 1 41.846  ? 861  HOH A O   1 
HETATM 5072 O  O   . HOH H 6 .   ? -20.913 45.367 39.247 1 34.052  ? 862  HOH A O   1 
HETATM 5073 O  O   . HOH H 6 .   ? -17.847 25.205 53.495 1 29.469  ? 863  HOH A O   1 
HETATM 5074 O  O   . HOH H 6 .   ? -16.431 36.01  38.278 1 28.226  ? 864  HOH A O   1 
HETATM 5075 O  O   . HOH H 6 .   ? -30.408 31.173 48.334 1 29.939  ? 865  HOH A O   1 
HETATM 5076 O  O   . HOH H 6 .   ? -22.878 22.212 53.446 1 44.672  ? 866  HOH A O   1 
HETATM 5077 O  O   . HOH H 6 .   ? -38.334 41.091 56.331 1 28.404  ? 867  HOH A O   1 
HETATM 5078 O  O   . HOH H 6 .   ? -25.812 16.047 21.328 1 44.977  ? 868  HOH A O   1 
HETATM 5079 O  O   . HOH H 6 .   ? -13.439 36.676 48.21  1 29.635  ? 869  HOH A O   1 
HETATM 5080 O  O   . HOH H 6 .   ? -42.132 28.93  35.333 1 35.764  ? 870  HOH A O   1 
HETATM 5081 O  O   . HOH H 6 .   ? -43.967 20.597 28.693 1 44.719  ? 871  HOH A O   1 
HETATM 5082 O  O   . HOH H 6 .   ? -5.724  12.461 27.604 1 42.26   ? 872  HOH A O   1 
HETATM 5083 O  O   . HOH H 6 .   ? -12.364 40.904 31.389 1 28.44   ? 873  HOH A O   1 
HETATM 5084 O  O   . HOH H 6 .   ? -31.596 30.932 45.991 1 28.242  ? 874  HOH A O   1 
HETATM 5085 O  O   . HOH H 6 .   ? -44.975 39.745 48.158 1 39.972  ? 875  HOH A O   1 
HETATM 5086 O  O   . HOH H 6 .   ? -45.654 31.423 48.848 1 30.496  ? 876  HOH A O   1 
HETATM 5087 O  O   . HOH H 6 .   ? -36.55  40.565 42.964 1 37.362  ? 877  HOH A O   1 
HETATM 5088 O  O   . HOH H 6 .   ? 2.702   7.047  46.679 1 36.351  ? 878  HOH A O   1 
HETATM 5089 O  O   . HOH H 6 .   ? -49.748 31.648 49.378 1 36.709  ? 879  HOH A O   1 
HETATM 5090 O  O   . HOH H 6 .   ? -21.779 31.118 24.405 1 28.219  ? 880  HOH A O   1 
HETATM 5091 O  O   . HOH H 6 .   ? -32.137 41.071 54.338 1 27.264  ? 881  HOH A O   1 
HETATM 5092 O  O   . HOH H 6 .   ? -12.79  33.25  36.741 1 32.836  ? 882  HOH A O   1 
HETATM 5093 O  O   . HOH H 6 .   ? 0.719   15.301 39.125 1 31.959  ? 883  HOH A O   1 
HETATM 5094 O  O   . HOH H 6 .   ? -31.833 11.223 44.218 1 39.498  ? 884  HOH A O   1 
HETATM 5095 O  O   . HOH H 6 .   ? -24.757 33.664 53.191 1 28.126  ? 885  HOH A O   1 
HETATM 5096 O  O   . HOH H 6 .   ? -38.567 18.218 28.535 1 41.171  ? 886  HOH A O   1 
HETATM 5097 O  O   . HOH H 6 .   ? -42.843 32.536 38.06  1 37.763  ? 887  HOH A O   1 
HETATM 5098 O  O   . HOH H 6 .   ? -32.796 4.222  50.307 1 32.081  ? 888  HOH A O   1 
HETATM 5099 O  O   . HOH H 6 .   ? -23.056 52.702 48.49  1 38.089  ? 889  HOH A O   1 
HETATM 5100 O  O   . HOH H 6 .   ? -16.738 15.509 58.333 1 35.001  ? 890  HOH A O   1 
HETATM 5101 O  O   . HOH H 6 .   ? -15.877 18.219 38.484 1 28.813  ? 891  HOH A O   1 
HETATM 5102 O  O   . HOH H 6 .   ? -3.842  32.461 19.669 1 44.654  ? 892  HOH A O   1 
HETATM 5103 O  O   . HOH H 6 .   ? -2.633  30.256 60.108 1 42.114  ? 893  HOH A O   1 
HETATM 5104 O  O   . HOH H 6 .   ? -26.897 21.68  53.6   1 45.002  ? 894  HOH A O   1 
HETATM 5105 O  O   . HOH H 6 .   ? 6.905   22.504 49.321 1 37.761  ? 895  HOH A O   1 
HETATM 5106 O  O   . HOH H 6 .   ? -19.939 23.48  53.121 1 35.296  ? 896  HOH A O   1 
HETATM 5107 O  O   . HOH H 6 .   ? -9.322  23.678 25.244 1 35.162  ? 897  HOH A O   1 
HETATM 5108 O  O   . HOH H 6 .   ? -11.276 7.321  37.906 1 33.977  ? 898  HOH A O   1 
HETATM 5109 O  O   . HOH H 6 .   ? -36.884 11.468 45.088 1 32.117  ? 899  HOH A O   1 
HETATM 5110 O  O   . HOH H 6 .   ? -28.39  24.234 30.34  1 27.1    ? 900  HOH A O   1 
HETATM 5111 O  O   . HOH H 6 .   ? -31.887 4.972  52.836 1 28.954  ? 901  HOH A O   1 
HETATM 5112 O  O   . HOH H 6 .   ? -11.298 10.345 38.004 1 26.412  ? 902  HOH A O   1 
HETATM 5113 O  O   . HOH H 6 .   ? -15.647 47.754 34.941 1 46.064  ? 903  HOH A O   1 
HETATM 5114 O  O   . HOH H 6 .   ? -48.418 29.162 38.617 1 38.031  ? 904  HOH A O   1 
HETATM 5115 O  O   . HOH H 6 .   ? -31.602 39.225 52.346 1 30.887  ? 905  HOH A O   1 
HETATM 5116 O  O   . HOH H 6 .   ? -37.348 15.429 27.795 1 38.191  ? 906  HOH A O   1 
HETATM 5117 O  O   . HOH H 6 .   ? -21.147 41.193 53.798 1 31.126  ? 907  HOH A O   1 
HETATM 5118 O  O   . HOH H 6 .   ? -37.037 37.001 34.162 1 35.794  ? 908  HOH A O   1 
HETATM 5119 O  O   . HOH H 6 .   ? -6.122  31.692 21.67  1 39.192  ? 909  HOH A O   1 
HETATM 5120 O  O   . HOH H 6 .   ? -2.999  13.04  29.817 1 38.326  ? 910  HOH A O   1 
HETATM 5121 O  O   . HOH H 6 .   ? -8.078  34.125 29.408 1 44.741  ? 911  HOH A O   1 
HETATM 5122 O  O   . HOH H 6 .   ? -33.62  7.477  30.66  1 45.537  ? 912  HOH A O   1 
HETATM 5123 O  O   . HOH H 6 .   ? -26.774 19.221 25.019 1 45.909  ? 913  HOH A O   1 
HETATM 5124 O  O   . HOH H 6 .   ? -52.086 31.376 52.269 1 39.007  ? 914  HOH A O   1 
HETATM 5125 O  O   . HOH H 6 .   ? -10.683 45.839 32.211 1 28.236  ? 915  HOH A O   1 
HETATM 5126 O  O   . HOH H 6 .   ? -16.444 39.119 30.091 1 36.298  ? 916  HOH A O   1 
HETATM 5127 O  O   . HOH H 6 .   ? -0.691  15.556 37.069 1 33.839  ? 917  HOH A O   1 
HETATM 5128 O  O   . HOH H 6 .   ? -41.477 34.175 54.179 1 38.05   ? 918  HOH A O   1 
HETATM 5129 O  O   . HOH H 6 .   ? -1.933  32.88  51.684 1 33.819  ? 919  HOH A O   1 
HETATM 5130 O  O   . HOH H 6 .   ? -3.735  25.939 51.657 1 35.805  ? 920  HOH A O   1 
HETATM 5131 O  O   . HOH H 6 .   ? -30.982 38.49  34.557 1 42.725  ? 921  HOH A O   1 
HETATM 5132 O  O   . HOH H 6 .   ? -28.579 23.445 26.119 1 46.406  ? 922  HOH A O   1 
HETATM 5133 O  O   . HOH H 6 .   ? -11.063 31.612 37.928 1 41.324  ? 923  HOH A O   1 
HETATM 5134 O  O   . HOH H 6 .   ? -29.27  29.659 56.353 1 32.458  ? 924  HOH A O   1 
HETATM 5135 O  O   . HOH H 6 .   ? -26.093 50.06  60.043 1 44.479  ? 925  HOH A O   1 
HETATM 5136 O  O   . HOH H 6 .   ? -41.997 33.251 45.164 1 30.063  ? 926  HOH A O   1 
HETATM 5137 O  O   . HOH H 6 .   ? -42.046 2.962  46.09  1 45.645  ? 927  HOH A O   1 
HETATM 5138 O  O   . HOH H 6 .   ? -6.41   49.553 45.485 1 47.589  ? 928  HOH A O   1 
HETATM 5139 O  O   . HOH H 6 .   ? -12.03  31.265 64.041 1 39.08   ? 929  HOH A O   1 
HETATM 5140 O  O   . HOH H 6 .   ? -14.762 12.659 58.269 1 38.045  ? 930  HOH A O   1 
HETATM 5141 O  O   . HOH H 6 .   ? -18.956 40.36  30.145 1 36.525  ? 931  HOH A O   1 
HETATM 5142 O  O   . HOH H 6 .   ? -4.275  22.025 42.056 1 41.546  ? 932  HOH A O   1 
HETATM 5143 O  O   . HOH H 6 .   ? -9.88   23.39  61.931 1 33.909  ? 933  HOH A O   1 
HETATM 5144 O  O   . HOH H 6 .   ? 0.707   22.87  22.419 1 46.501  ? 934  HOH A O   1 
HETATM 5145 O  O   . HOH H 6 .   ? 6.415   41.333 22.68  1 37.919  ? 935  HOH A O   1 
HETATM 5146 O  O   . HOH H 6 .   ? -32.624 24.417 58.165 1 36.451  ? 936  HOH A O   1 
HETATM 5147 O  O   . HOH H 6 .   ? -38.528 33.356 61.657 1 42.833  ? 937  HOH A O   1 
HETATM 5148 O  O   . HOH H 6 .   ? -40.895 39.594 44.055 1 47.002  ? 938  HOH A O   1 
HETATM 5149 O  O   . HOH H 6 .   ? -38.574 24.228 31.986 1 39.766  ? 939  HOH A O   1 
HETATM 5150 O  O   . HOH H 6 .   ? -15.977 26.798 59.285 1 42.191  ? 940  HOH A O   1 
HETATM 5151 O  O   . HOH H 6 .   ? -1.48   25.68  34.763 1 40.64   ? 941  HOH A O   1 
HETATM 5152 O  O   . HOH H 6 .   ? -8.878  35.475 43.2   1 46.172  ? 942  HOH A O   1 
HETATM 5153 O  O   . HOH H 6 .   ? -49.785 29.659 61.744 1 39.248  ? 943  HOH A O   1 
HETATM 5154 O  O   . HOH H 6 .   ? -2.347  49.337 40.59  1 33.611  ? 944  HOH A O   1 
HETATM 5155 O  O   . HOH H 6 .   ? -12.261 48.263 44.828 1 32.828  ? 945  HOH A O   1 
HETATM 5156 O  O   . HOH H 6 .   ? -36.999 31.698 63.728 1 41.66   ? 946  HOH A O   1 
HETATM 5157 O  O   . HOH H 6 .   ? -47.49  31.196 50.736 1 41.143  ? 947  HOH A O   1 
HETATM 5158 O  O   . HOH H 6 .   ? -34.629 6.324  49.501 1 32.66   ? 948  HOH A O   1 
HETATM 5159 O  O   . HOH H 6 .   ? -29.877 34.017 67.529 1 47.742  ? 949  HOH A O   1 
HETATM 5160 O  O   . HOH H 6 .   ? -36.401 10.099 37.744 1 41.32   ? 950  HOH A O   1 
HETATM 5161 O  O   . HOH H 6 .   ? -12.773 4.562  54.675 1 42.068  ? 951  HOH A O   1 
HETATM 5162 O  O   . HOH H 6 .   ? -44.783 19.375 57.762 1 37.957  ? 952  HOH A O   1 
HETATM 5163 O  O   . HOH H 6 .   ? -7.201  3.655  33.227 1 40.727  ? 953  HOH A O   1 
HETATM 5164 O  O   . HOH H 6 .   ? -17.462 17.786 52.113 1 40.983  ? 954  HOH A O   1 
HETATM 5165 O  O   . HOH H 6 .   ? -24.798 24.009 55.686 1 32.93   ? 955  HOH A O   1 
HETATM 5166 O  O   . HOH H 6 .   ? 6.382   24.79  22.704 1 44.693  ? 956  HOH A O   1 
HETATM 5167 O  O   . HOH H 6 .   ? -34.788 2.221  50.085 1 42.841  ? 957  HOH A O   1 
HETATM 5168 O  O   . HOH H 6 .   ? -10.162 32.449 42.522 1 35.181  ? 958  HOH A O   1 
HETATM 5169 O  O   . HOH H 6 .   ? -7.277  41     40.726 1 30.148  ? 959  HOH A O   1 
HETATM 5170 O  O   . HOH H 6 .   ? 3.511   17.848 29.925 1 58.287  ? 960  HOH A O   1 
HETATM 5171 O  O   . HOH H 6 .   ? -9.368  39.217 40.789 1 35.932  ? 961  HOH A O   1 
HETATM 5172 O  O   . HOH H 6 .   ? -19.045 28.423 29.358 1 32.372  ? 962  HOH A O   1 
HETATM 5173 O  O   . HOH H 6 .   ? -16.994 20.381 51.926 1 30.593  ? 963  HOH A O   1 
HETATM 5174 O  O   . HOH H 6 .   ? 4.608   21.086 31.183 1 41.669  ? 964  HOH A O   1 
HETATM 5175 O  O   . HOH H 6 .   ? 12.426  33.614 42.45  1 40.495  ? 965  HOH A O   1 
HETATM 5176 O  O   . HOH H 6 .   ? -48.649 35.574 43.03  1 43.465  ? 966  HOH A O   1 
HETATM 5177 O  O   . HOH H 6 .   ? -16.387 43.07  32.311 1 47.893  ? 967  HOH A O   1 
HETATM 5178 O  O   . HOH H 6 .   ? -9.907  27.107 33.795 1 53.094  ? 968  HOH A O   1 
HETATM 5179 O  O   . HOH H 6 .   ? -6.597  39.763 28.434 1 44.653  ? 969  HOH A O   1 
HETATM 5180 O  O   . HOH H 6 .   ? -24.763 42.588 31.887 1 51.565  ? 970  HOH A O   1 
HETATM 5181 O  O   . HOH H 6 .   ? 4.656   41.061 20.521 1 39.589  ? 971  HOH A O   1 
HETATM 5182 O  O   . HOH H 6 .   ? -10.158 16.12  20.65  1 47.539  ? 972  HOH A O   1 
HETATM 5183 O  O   . HOH H 6 .   ? -26.965 33.411 68.837 1 52.612  ? 973  HOH A O   1 
HETATM 5184 O  O   . HOH H 6 .   ? -19.066 27.476 52.814 1 30.346  ? 974  HOH A O   1 
HETATM 5185 O  O   . HOH H 6 .   ? -0.683  13.717 52.334 1 42.387  ? 975  HOH A O   1 
HETATM 5186 O  O   . HOH H 6 .   ? -28.787 16.492 42.706 1 47.09   ? 976  HOH A O   1 
HETATM 5187 O  O   . HOH H 6 .   ? -15.841 53.671 50.27  1 43.977  ? 977  HOH A O   1 
HETATM 5188 O  O   . HOH H 6 .   ? -21.368 41.48  28.828 1 31.573  ? 978  HOH A O   1 
HETATM 5189 O  O   . HOH H 6 .   ? -33.652 40.351 65.349 1 39.63   ? 979  HOH A O   1 
HETATM 5190 O  O   . HOH H 6 .   ? -38.081 37.867 38.772 1 60.399  ? 980  HOH A O   1 
HETATM 5191 O  O   . HOH H 6 .   ? -22.138 3.179  25.12  1 36.613  ? 981  HOH A O   1 
HETATM 5192 O  O   . HOH H 6 .   ? -46.614 26.508 28.889 1 49.728  ? 982  HOH A O   1 
HETATM 5193 O  O   . HOH H 6 .   ? -30.46  15.21  46.784 1 53.97   ? 983  HOH A O   1 
HETATM 5194 O  O   . HOH H 6 .   ? -7.634  9.477  54.829 1 36.561  ? 984  HOH A O   1 
HETATM 5195 O  O   . HOH H 6 .   ? -31.602 14.772 53.603 1 47.03   ? 985  HOH A O   1 
HETATM 5196 O  O   . HOH H 6 .   ? -16.757 31.516 19.03  1 47.442  ? 986  HOH A O   1 
HETATM 5197 O  O   . HOH H 6 .   ? -20.71  45.101 33.366 1 44.089  ? 987  HOH A O   1 
HETATM 5198 O  O   . HOH H 6 .   ? -4.372  50.589 35.083 1 38.954  ? 988  HOH A O   1 
HETATM 5199 O  O   . HOH H 6 .   ? -16.209 45.78  32.178 1 38.467  ? 989  HOH A O   1 
HETATM 5200 O  O   . HOH H 6 .   ? -9.13   8.268  28.301 1 40.605  ? 990  HOH A O   1 
HETATM 5201 O  O   . HOH H 6 .   ? -1.95   13.378 57.232 1 44.07   ? 991  HOH A O   1 
HETATM 5202 O  O   . HOH H 6 .   ? -27.727 16.615 47.669 1 50.318  ? 992  HOH A O   1 
HETATM 5203 O  O   . HOH H 6 .   ? -26.707 15.311 41.478 1 43.361  ? 993  HOH A O   1 
HETATM 5204 O  O   . HOH H 6 .   ? -4.209  31.003 52.669 1 52.94   ? 994  HOH A O   1 
HETATM 5205 O  O   . HOH H 6 .   ? -2.99   34.809 21.932 1 47.601  ? 995  HOH A O   1 
HETATM 5206 O  O   . HOH H 6 .   ? -23.402 42.466 37.863 1 39.795  ? 996  HOH A O   1 
HETATM 5207 O  O   . HOH H 6 .   ? -8.523  1.645  46.333 1 44.678  ? 997  HOH A O   1 
HETATM 5208 O  O   . HOH H 6 .   ? -3.148  35.034 41.002 1 38.327  ? 998  HOH A O   1 
HETATM 5209 O  O   . HOH H 6 .   ? -30.77  13.839 44.455 1 35.362  ? 999  HOH A O   1 
HETATM 5210 O  O   . HOH H 6 .   ? -19.724 30.271 17.835 1 50.632  ? 1000 HOH A O   1 
HETATM 5211 O  O   . HOH H 6 .   ? -6.01   10.204 28.755 1 45.719  ? 1001 HOH A O   1 
HETATM 5212 O  O   . HOH H 6 .   ? -21.298 15.722 17.702 1 48.579  ? 1002 HOH A O   1 
HETATM 5213 O  O   . HOH H 6 .   ? -23.124 19.466 48.974 1 51.8    ? 1003 HOH A O   1 
HETATM 5214 O  O   . HOH H 6 .   ? -15.936 23.679 55.604 1 41.86   ? 1004 HOH A O   1 
HETATM 5215 O  O   . HOH H 6 .   ? -18.026 31.221 17.204 1 53.498  ? 1005 HOH A O   1 
HETATM 5216 O  O   . HOH H 6 .   ? -6.409  25.889 49.722 1 44.505  ? 1006 HOH A O   1 
HETATM 5217 O  O   . HOH H 6 .   ? -6.919  33.213 43.479 1 44.277  ? 1007 HOH A O   1 
HETATM 5218 O  O   . HOH H 6 .   ? -23.911 3.343  23.515 1 51.5    ? 1008 HOH A O   1 
HETATM 5219 O  O   . HOH H 6 .   ? -7.256  36.714 40.627 1 33.037  ? 1009 HOH A O   1 
HETATM 5220 O  O   . HOH H 6 .   ? -0.77   14.995 54.74  1 46.661  ? 1010 HOH A O   1 
HETATM 5221 O  O   . HOH H 6 .   ? -31.739 43.342 52.927 1 35.995  ? 1011 HOH A O   1 
HETATM 5222 O  O   . HOH H 6 .   ? -9.068  29.824 37.333 1 46.49   ? 1012 HOH A O   1 
HETATM 5223 O  O   . HOH H 6 .   ? -2.838  10.108 54.546 1 46.507  ? 1013 HOH A O   1 
HETATM 5224 O  O   . HOH H 6 .   ? -10.702 49.042 47.368 1 45.404  ? 1014 HOH A O   1 
HETATM 5225 O  O   . HOH H 6 .   ? -10.81  25.229 47.333 1 51.942  ? 1015 HOH A O   1 
HETATM 5226 O  O   . HOH H 6 .   ? -5.169  40.287 39.111 1 39.887  ? 1016 HOH A O   1 
HETATM 5227 O  O   . HOH H 6 .   ? -8.968  29.628 42.683 1 40.592  ? 1017 HOH A O   1 
HETATM 5228 O  O   . HOH H 6 .   ? -2.5    32.59  49.145 1 41.118  ? 1018 HOH A O   1 
HETATM 5229 O  O   . HOH H 6 .   ? -40.099 17.553 61.714 1 43.417  ? 1019 HOH A O   1 
HETATM 5230 O  O   . HOH H 6 .   ? 1.209   17.089 55.671 1 49.756  ? 1020 HOH A O   1 
HETATM 5231 O  O   . HOH H 6 .   ? -38.924 36.543 36.369 1 44.551  ? 1021 HOH A O   1 
HETATM 5232 O  O   . HOH H 6 .   ? -20.415 40.396 66.555 1 42.928  ? 1022 HOH A O   1 
HETATM 5233 O  O   . HOH H 6 .   ? 4.365   7.672  38.822 1 41.538  ? 1023 HOH A O   1 
HETATM 5234 O  O   . HOH H 6 .   ? -44.719 15.005 56.157 1 48.338  ? 1024 HOH A O   1 
HETATM 5235 O  O   . HOH H 6 .   ? 15.407  20.341 21.219 1 48.21   ? 1025 HOH A O   1 
HETATM 5236 O  O   . HOH H 6 .   ? -19.294 35.385 68.508 1 49.1    ? 1026 HOH A O   1 
HETATM 5237 O  O   . HOH H 6 .   ? -5.694  36.982 36.655 1 41.376  ? 1027 HOH A O   1 
HETATM 5238 O  O   . HOH H 6 .   ? -2.542  51.985 44.628 1 45.237  ? 1028 HOH A O   1 
HETATM 5239 O  O   . HOH H 6 .   ? -47.151 41.789 48.932 1 45.274  ? 1029 HOH A O   1 
HETATM 5240 O  O   . HOH H 6 .   ? -7.132  2.223  48.422 1 39.344  ? 1030 HOH A O   1 
HETATM 5241 O  O   . HOH H 6 .   ? -3.412  50.871 47.366 1 44.436  ? 1031 HOH A O   1 
HETATM 5242 O  O   . HOH H 6 .   ? -8.782  50.586 46.258 1 38.291  ? 1032 HOH A O   1 
HETATM 5243 O  O   . HOH H 6 .   ? -16.567 13.868 60.34  1 41.299  ? 1033 HOH A O   1 
HETATM 5244 O  O   . HOH H 6 .   ? -15.595 14.262 62.804 1 36.7    ? 1034 HOH A O   1 
HETATM 5245 O  O   . HOH H 6 .   ? -3.931  51.123 41.94  1 40.702  ? 1035 HOH A O   1 
HETATM 5246 O  O   . HOH H 6 .   ? -36.032 12.829 61.192 1 54.109  ? 1036 HOH A O   1 
HETATM 5247 O  O   . HOH H 6 .   ? -35.297 10.536 59.41  1 48.133  ? 1037 HOH A O   1 
HETATM 5248 O  O   . HOH I 6 .   ? -14.583 22.4   44.172 1 40.418  ? 1801 HOH B O   1 
HETATM 5249 O  O   . HOH I 6 .   ? -20.663 24.819 50.752 1 31.491  ? 1802 HOH B O   1 
HETATM 5250 O  O   . HOH I 6 .   ? -20.985 21.758 48.882 1 43.843  ? 1803 HOH B O   1 
HETATM 5251 O  O   . HOH J 6 .   ? -12.874 23.754 46.558 1 39.845  ? 1701 HOH D O   1 
HETATM 5252 O  O   . HOH J 6 .   ? -8.861  27.366 40.926 1 48.679  ? 1702 HOH D O   1 
HETATM 5253 O  O   . HOH J 6 .   ? -5.143  22.514 39.444 1 36.138  ? 1703 HOH D O   1 
# 
