data_8PVW
# 
_entry.id   8PVW 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   8PVW         pdb_00008pvw 10.2210/pdb8pvw/pdb 
WWPDB D_1292131929 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-02-05 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        8PVW 
_pdbx_database_status.recvd_initial_deposition_date   2023-07-18 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              magnus.wolf-watz@umu.se 
_pdbx_contact_author.name_first         Magnus 
_pdbx_contact_author.name_last          Wolf-Watz 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-9098-7974 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Rodriguez, J.A.'    1 0000-0003-1693-3916 
'Wolf Watz, M.'      2 0000-0002-9098-7974 
'Sauer-Eriksson, E.' 3 ?                   
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Structure of a short E. coli adenylate kinase in complex with Ap5A' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Rodriguez, J.A.'  1 0000-0003-1693-3916 
primary 'Wolf Watz, M.'    2 0000-0002-9098-7974 
primary 'Nagy, T.M.'       3 0000-0001-6080-9782 
primary 'Phoeurk, C.'      4 ?                   
primary 'Rogne, P.'        5 ?                   
primary 'Schierholz, L.J.' 6 ?                   
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Adenylate kinase'                 20540.535 1   2.7.4.3 ? ? ? 
2 non-polymer syn "BIS(ADENOSINE)-5'-PENTAPHOSPHATE" 916.367   1   ?       ? ? ? 
3 water       nat water                              18.015    114 ?       ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MRIILLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAVKSGSELGKQAKDIMDAGKLVTDELVIALVKERIAQEDCRNG
FLLDGFPRTIPQADAMKEAGINVDYVLEFDVPDELIVDRILKRGETSGRVDDNEETVRKRLVEYHQMTAPLIGYYSKEAE
AGNTKYAKVDGTKPVAEVRADLEKILG
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MRIILLGAPGAGKGTQAQFIMEKYGIPQISTGDMLRAAVKSGSELGKQAKDIMDAGKLVTDELVIALVKERIAQEDCRNG
FLLDGFPRTIPQADAMKEAGINVDYVLEFDVPDELIVDRILKRGETSGRVDDNEETVRKRLVEYHQMTAPLIGYYSKEAE
AGNTKYAKVDGTKPVAEVRADLEKILG
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 "BIS(ADENOSINE)-5'-PENTAPHOSPHATE" AP5 
3 water                              HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ARG n 
1 3   ILE n 
1 4   ILE n 
1 5   LEU n 
1 6   LEU n 
1 7   GLY n 
1 8   ALA n 
1 9   PRO n 
1 10  GLY n 
1 11  ALA n 
1 12  GLY n 
1 13  LYS n 
1 14  GLY n 
1 15  THR n 
1 16  GLN n 
1 17  ALA n 
1 18  GLN n 
1 19  PHE n 
1 20  ILE n 
1 21  MET n 
1 22  GLU n 
1 23  LYS n 
1 24  TYR n 
1 25  GLY n 
1 26  ILE n 
1 27  PRO n 
1 28  GLN n 
1 29  ILE n 
1 30  SER n 
1 31  THR n 
1 32  GLY n 
1 33  ASP n 
1 34  MET n 
1 35  LEU n 
1 36  ARG n 
1 37  ALA n 
1 38  ALA n 
1 39  VAL n 
1 40  LYS n 
1 41  SER n 
1 42  GLY n 
1 43  SER n 
1 44  GLU n 
1 45  LEU n 
1 46  GLY n 
1 47  LYS n 
1 48  GLN n 
1 49  ALA n 
1 50  LYS n 
1 51  ASP n 
1 52  ILE n 
1 53  MET n 
1 54  ASP n 
1 55  ALA n 
1 56  GLY n 
1 57  LYS n 
1 58  LEU n 
1 59  VAL n 
1 60  THR n 
1 61  ASP n 
1 62  GLU n 
1 63  LEU n 
1 64  VAL n 
1 65  ILE n 
1 66  ALA n 
1 67  LEU n 
1 68  VAL n 
1 69  LYS n 
1 70  GLU n 
1 71  ARG n 
1 72  ILE n 
1 73  ALA n 
1 74  GLN n 
1 75  GLU n 
1 76  ASP n 
1 77  CYS n 
1 78  ARG n 
1 79  ASN n 
1 80  GLY n 
1 81  PHE n 
1 82  LEU n 
1 83  LEU n 
1 84  ASP n 
1 85  GLY n 
1 86  PHE n 
1 87  PRO n 
1 88  ARG n 
1 89  THR n 
1 90  ILE n 
1 91  PRO n 
1 92  GLN n 
1 93  ALA n 
1 94  ASP n 
1 95  ALA n 
1 96  MET n 
1 97  LYS n 
1 98  GLU n 
1 99  ALA n 
1 100 GLY n 
1 101 ILE n 
1 102 ASN n 
1 103 VAL n 
1 104 ASP n 
1 105 TYR n 
1 106 VAL n 
1 107 LEU n 
1 108 GLU n 
1 109 PHE n 
1 110 ASP n 
1 111 VAL n 
1 112 PRO n 
1 113 ASP n 
1 114 GLU n 
1 115 LEU n 
1 116 ILE n 
1 117 VAL n 
1 118 ASP n 
1 119 ARG n 
1 120 ILE n 
1 121 LEU n 
1 122 LYS n 
1 123 ARG n 
1 124 GLY n 
1 125 GLU n 
1 126 THR n 
1 127 SER n 
1 128 GLY n 
1 129 ARG n 
1 130 VAL n 
1 131 ASP n 
1 132 ASP n 
1 133 ASN n 
1 134 GLU n 
1 135 GLU n 
1 136 THR n 
1 137 VAL n 
1 138 ARG n 
1 139 LYS n 
1 140 ARG n 
1 141 LEU n 
1 142 VAL n 
1 143 GLU n 
1 144 TYR n 
1 145 HIS n 
1 146 GLN n 
1 147 MET n 
1 148 THR n 
1 149 ALA n 
1 150 PRO n 
1 151 LEU n 
1 152 ILE n 
1 153 GLY n 
1 154 TYR n 
1 155 TYR n 
1 156 SER n 
1 157 LYS n 
1 158 GLU n 
1 159 ALA n 
1 160 GLU n 
1 161 ALA n 
1 162 GLY n 
1 163 ASN n 
1 164 THR n 
1 165 LYS n 
1 166 TYR n 
1 167 ALA n 
1 168 LYS n 
1 169 VAL n 
1 170 ASP n 
1 171 GLY n 
1 172 THR n 
1 173 LYS n 
1 174 PRO n 
1 175 VAL n 
1 176 ALA n 
1 177 GLU n 
1 178 VAL n 
1 179 ARG n 
1 180 ALA n 
1 181 ASP n 
1 182 LEU n 
1 183 GLU n 
1 184 LYS n 
1 185 ILE n 
1 186 LEU n 
1 187 GLY n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   187 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'adk, dnaW, plsA, b0474, JW0463' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    BL21 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Escherichia coli K-12' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     83333 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                            ? 'C3 H7 N O2'         89.093  
AP5 non-polymer         . "BIS(ADENOSINE)-5'-PENTAPHOSPHATE" ? 'C20 H29 N10 O22 P5' 916.367 
ARG 'L-peptide linking' y ARGININE                           ? 'C6 H15 N4 O2 1'     175.209 
ASN 'L-peptide linking' y ASPARAGINE                         ? 'C4 H8 N2 O3'        132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                    ? 'C4 H7 N O4'         133.103 
CYS 'L-peptide linking' y CYSTEINE                           ? 'C3 H7 N O2 S'       121.158 
GLN 'L-peptide linking' y GLUTAMINE                          ? 'C5 H10 N2 O3'       146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                    ? 'C5 H9 N O4'         147.129 
GLY 'peptide linking'   y GLYCINE                            ? 'C2 H5 N O2'         75.067  
HIS 'L-peptide linking' y HISTIDINE                          ? 'C6 H10 N3 O2 1'     156.162 
HOH non-polymer         . WATER                              ? 'H2 O'               18.015  
ILE 'L-peptide linking' y ISOLEUCINE                         ? 'C6 H13 N O2'        131.173 
LEU 'L-peptide linking' y LEUCINE                            ? 'C6 H13 N O2'        131.173 
LYS 'L-peptide linking' y LYSINE                             ? 'C6 H15 N2 O2 1'     147.195 
MET 'L-peptide linking' y METHIONINE                         ? 'C5 H11 N O2 S'      149.211 
PHE 'L-peptide linking' y PHENYLALANINE                      ? 'C9 H11 N O2'        165.189 
PRO 'L-peptide linking' y PROLINE                            ? 'C5 H9 N O2'         115.130 
SER 'L-peptide linking' y SERINE                             ? 'C3 H7 N O3'         105.093 
THR 'L-peptide linking' y THREONINE                          ? 'C4 H9 N O3'         119.119 
TYR 'L-peptide linking' y TYROSINE                           ? 'C9 H11 N O3'        181.189 
VAL 'L-peptide linking' y VALINE                             ? 'C5 H11 N O2'        117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   1   MET MET A . n 
A 1 2   ARG 2   2   2   ARG ARG A . n 
A 1 3   ILE 3   3   3   ILE ILE A . n 
A 1 4   ILE 4   4   4   ILE ILE A . n 
A 1 5   LEU 5   5   5   LEU LEU A . n 
A 1 6   LEU 6   6   6   LEU LEU A . n 
A 1 7   GLY 7   7   7   GLY GLY A . n 
A 1 8   ALA 8   8   8   ALA ALA A . n 
A 1 9   PRO 9   9   9   PRO PRO A . n 
A 1 10  GLY 10  10  10  GLY GLY A . n 
A 1 11  ALA 11  11  11  ALA ALA A . n 
A 1 12  GLY 12  12  12  GLY GLY A . n 
A 1 13  LYS 13  13  13  LYS LYS A . n 
A 1 14  GLY 14  14  14  GLY GLY A . n 
A 1 15  THR 15  15  15  THR THR A . n 
A 1 16  GLN 16  16  16  GLN GLN A . n 
A 1 17  ALA 17  17  17  ALA ALA A . n 
A 1 18  GLN 18  18  18  GLN GLN A . n 
A 1 19  PHE 19  19  19  PHE PHE A . n 
A 1 20  ILE 20  20  20  ILE ILE A . n 
A 1 21  MET 21  21  21  MET MET A . n 
A 1 22  GLU 22  22  22  GLU GLU A . n 
A 1 23  LYS 23  23  23  LYS LYS A . n 
A 1 24  TYR 24  24  24  TYR TYR A . n 
A 1 25  GLY 25  25  25  GLY GLY A . n 
A 1 26  ILE 26  26  26  ILE ILE A . n 
A 1 27  PRO 27  27  27  PRO PRO A . n 
A 1 28  GLN 28  28  28  GLN GLN A . n 
A 1 29  ILE 29  29  29  ILE ILE A . n 
A 1 30  SER 30  30  30  SER SER A . n 
A 1 31  THR 31  31  31  THR THR A . n 
A 1 32  GLY 32  32  32  GLY GLY A . n 
A 1 33  ASP 33  33  33  ASP ASP A . n 
A 1 34  MET 34  34  34  MET MET A . n 
A 1 35  LEU 35  35  35  LEU LEU A . n 
A 1 36  ARG 36  36  36  ARG ARG A . n 
A 1 37  ALA 37  37  37  ALA ALA A . n 
A 1 38  ALA 38  38  38  ALA ALA A . n 
A 1 39  VAL 39  39  39  VAL VAL A . n 
A 1 40  LYS 40  40  40  LYS LYS A . n 
A 1 41  SER 41  41  41  SER SER A . n 
A 1 42  GLY 42  42  42  GLY GLY A . n 
A 1 43  SER 43  43  43  SER SER A . n 
A 1 44  GLU 44  44  44  GLU GLU A . n 
A 1 45  LEU 45  45  45  LEU LEU A . n 
A 1 46  GLY 46  46  46  GLY GLY A . n 
A 1 47  LYS 47  47  47  LYS LYS A . n 
A 1 48  GLN 48  48  48  GLN GLN A . n 
A 1 49  ALA 49  49  49  ALA ALA A . n 
A 1 50  LYS 50  50  50  LYS LYS A . n 
A 1 51  ASP 51  51  51  ASP ASP A . n 
A 1 52  ILE 52  52  52  ILE ILE A . n 
A 1 53  MET 53  53  53  MET MET A . n 
A 1 54  ASP 54  54  54  ASP ASP A . n 
A 1 55  ALA 55  55  55  ALA ALA A . n 
A 1 56  GLY 56  56  56  GLY GLY A . n 
A 1 57  LYS 57  57  57  LYS LYS A . n 
A 1 58  LEU 58  58  58  LEU LEU A . n 
A 1 59  VAL 59  59  59  VAL VAL A . n 
A 1 60  THR 60  60  60  THR THR A . n 
A 1 61  ASP 61  61  61  ASP ASP A . n 
A 1 62  GLU 62  62  62  GLU GLU A . n 
A 1 63  LEU 63  63  63  LEU LEU A . n 
A 1 64  VAL 64  64  64  VAL VAL A . n 
A 1 65  ILE 65  65  65  ILE ILE A . n 
A 1 66  ALA 66  66  66  ALA ALA A . n 
A 1 67  LEU 67  67  67  LEU LEU A . n 
A 1 68  VAL 68  68  68  VAL VAL A . n 
A 1 69  LYS 69  69  69  LYS LYS A . n 
A 1 70  GLU 70  70  70  GLU GLU A . n 
A 1 71  ARG 71  71  71  ARG ARG A . n 
A 1 72  ILE 72  72  72  ILE ILE A . n 
A 1 73  ALA 73  73  73  ALA ALA A . n 
A 1 74  GLN 74  74  74  GLN GLN A . n 
A 1 75  GLU 75  75  75  GLU GLU A . n 
A 1 76  ASP 76  76  76  ASP ASP A . n 
A 1 77  CYS 77  77  77  CYS CYS A . n 
A 1 78  ARG 78  78  78  ARG ARG A . n 
A 1 79  ASN 79  79  79  ASN ASN A . n 
A 1 80  GLY 80  80  80  GLY GLY A . n 
A 1 81  PHE 81  81  81  PHE PHE A . n 
A 1 82  LEU 82  82  82  LEU LEU A . n 
A 1 83  LEU 83  83  83  LEU LEU A . n 
A 1 84  ASP 84  84  84  ASP ASP A . n 
A 1 85  GLY 85  85  85  GLY GLY A . n 
A 1 86  PHE 86  86  86  PHE PHE A . n 
A 1 87  PRO 87  87  87  PRO PRO A . n 
A 1 88  ARG 88  88  88  ARG ARG A . n 
A 1 89  THR 89  89  89  THR THR A . n 
A 1 90  ILE 90  90  90  ILE ILE A . n 
A 1 91  PRO 91  91  91  PRO PRO A . n 
A 1 92  GLN 92  92  92  GLN GLN A . n 
A 1 93  ALA 93  93  93  ALA ALA A . n 
A 1 94  ASP 94  94  94  ASP ASP A . n 
A 1 95  ALA 95  95  95  ALA ALA A . n 
A 1 96  MET 96  96  96  MET MET A . n 
A 1 97  LYS 97  97  97  LYS LYS A . n 
A 1 98  GLU 98  98  98  GLU GLU A . n 
A 1 99  ALA 99  99  99  ALA ALA A . n 
A 1 100 GLY 100 100 100 GLY GLY A . n 
A 1 101 ILE 101 101 101 ILE ILE A . n 
A 1 102 ASN 102 102 102 ASN ASN A . n 
A 1 103 VAL 103 103 103 VAL VAL A . n 
A 1 104 ASP 104 104 104 ASP ASP A . n 
A 1 105 TYR 105 105 105 TYR TYR A . n 
A 1 106 VAL 106 106 106 VAL VAL A . n 
A 1 107 LEU 107 107 107 LEU LEU A . n 
A 1 108 GLU 108 108 108 GLU GLU A . n 
A 1 109 PHE 109 109 109 PHE PHE A . n 
A 1 110 ASP 110 110 110 ASP ASP A . n 
A 1 111 VAL 111 111 111 VAL VAL A . n 
A 1 112 PRO 112 112 112 PRO PRO A . n 
A 1 113 ASP 113 113 113 ASP ASP A . n 
A 1 114 GLU 114 114 114 GLU GLU A . n 
A 1 115 LEU 115 115 115 LEU LEU A . n 
A 1 116 ILE 116 116 116 ILE ILE A . n 
A 1 117 VAL 117 117 117 VAL VAL A . n 
A 1 118 ASP 118 118 118 ASP ASP A . n 
A 1 119 ARG 119 119 119 ARG ARG A . n 
A 1 120 ILE 120 120 120 ILE ILE A . n 
A 1 121 LEU 121 121 121 LEU LEU A . n 
A 1 122 LYS 122 122 122 LYS LYS A . n 
A 1 123 ARG 123 123 123 ARG ARG A . n 
A 1 124 GLY 124 124 124 GLY GLY A . n 
A 1 125 GLU 125 125 125 GLU GLU A . n 
A 1 126 THR 126 126 126 THR THR A . n 
A 1 127 SER 127 127 127 SER SER A . n 
A 1 128 GLY 128 128 128 GLY GLY A . n 
A 1 129 ARG 129 129 129 ARG ARG A . n 
A 1 130 VAL 130 130 130 VAL VAL A . n 
A 1 131 ASP 131 131 131 ASP ASP A . n 
A 1 132 ASP 132 132 132 ASP ASP A . n 
A 1 133 ASN 133 133 133 ASN ASN A . n 
A 1 134 GLU 134 134 134 GLU GLU A . n 
A 1 135 GLU 135 135 135 GLU GLU A . n 
A 1 136 THR 136 136 136 THR THR A . n 
A 1 137 VAL 137 137 137 VAL VAL A . n 
A 1 138 ARG 138 138 138 ARG ARG A . n 
A 1 139 LYS 139 139 139 LYS LYS A . n 
A 1 140 ARG 140 140 140 ARG ARG A . n 
A 1 141 LEU 141 141 141 LEU LEU A . n 
A 1 142 VAL 142 142 142 VAL VAL A . n 
A 1 143 GLU 143 143 143 GLU GLU A . n 
A 1 144 TYR 144 144 144 TYR TYR A . n 
A 1 145 HIS 145 145 145 HIS HIS A . n 
A 1 146 GLN 146 146 146 GLN GLN A . n 
A 1 147 MET 147 147 147 MET MET A . n 
A 1 148 THR 148 148 148 THR THR A . n 
A 1 149 ALA 149 149 149 ALA ALA A . n 
A 1 150 PRO 150 150 150 PRO PRO A . n 
A 1 151 LEU 151 151 151 LEU LEU A . n 
A 1 152 ILE 152 152 152 ILE ILE A . n 
A 1 153 GLY 153 153 153 GLY GLY A . n 
A 1 154 TYR 154 154 154 TYR TYR A . n 
A 1 155 TYR 155 155 155 TYR TYR A . n 
A 1 156 SER 156 156 156 SER SER A . n 
A 1 157 LYS 157 157 157 LYS LYS A . n 
A 1 158 GLU 158 158 158 GLU GLU A . n 
A 1 159 ALA 159 159 159 ALA ALA A . n 
A 1 160 GLU 160 160 160 GLU GLU A . n 
A 1 161 ALA 161 161 161 ALA ALA A . n 
A 1 162 GLY 162 162 162 GLY GLY A . n 
A 1 163 ASN 163 163 163 ASN ASN A . n 
A 1 164 THR 164 164 164 THR THR A . n 
A 1 165 LYS 165 165 165 LYS LYS A . n 
A 1 166 TYR 166 166 166 TYR TYR A . n 
A 1 167 ALA 167 167 167 ALA ALA A . n 
A 1 168 LYS 168 168 168 LYS LYS A . n 
A 1 169 VAL 169 169 169 VAL VAL A . n 
A 1 170 ASP 170 170 170 ASP ASP A . n 
A 1 171 GLY 171 171 171 GLY GLY A . n 
A 1 172 THR 172 172 172 THR THR A . n 
A 1 173 LYS 173 173 173 LYS LYS A . n 
A 1 174 PRO 174 174 174 PRO PRO A . n 
A 1 175 VAL 175 175 175 VAL VAL A . n 
A 1 176 ALA 176 176 176 ALA ALA A . n 
A 1 177 GLU 177 177 177 GLU GLU A . n 
A 1 178 VAL 178 178 178 VAL VAL A . n 
A 1 179 ARG 179 179 179 ARG ARG A . n 
A 1 180 ALA 180 180 180 ALA ALA A . n 
A 1 181 ASP 181 181 181 ASP ASP A . n 
A 1 182 LEU 182 182 182 LEU LEU A . n 
A 1 183 GLU 183 183 183 GLU GLU A . n 
A 1 184 LYS 184 184 184 LYS LYS A . n 
A 1 185 ILE 185 185 185 ILE ILE A . n 
A 1 186 LEU 186 186 186 LEU LEU A . n 
A 1 187 GLY 187 187 187 GLY GLY A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        AP5 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   AP5 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 AP5 1   301 301 AP5 AP5 A . 
C 3 HOH 1   401 102 HOH HOH A . 
C 3 HOH 2   402 39  HOH HOH A . 
C 3 HOH 3   403 12  HOH HOH A . 
C 3 HOH 4   404 71  HOH HOH A . 
C 3 HOH 5   405 103 HOH HOH A . 
C 3 HOH 6   406 100 HOH HOH A . 
C 3 HOH 7   407 108 HOH HOH A . 
C 3 HOH 8   408 101 HOH HOH A . 
C 3 HOH 9   409 75  HOH HOH A . 
C 3 HOH 10  410 42  HOH HOH A . 
C 3 HOH 11  411 26  HOH HOH A . 
C 3 HOH 12  412 90  HOH HOH A . 
C 3 HOH 13  413 73  HOH HOH A . 
C 3 HOH 14  414 95  HOH HOH A . 
C 3 HOH 15  415 72  HOH HOH A . 
C 3 HOH 16  416 107 HOH HOH A . 
C 3 HOH 17  417 69  HOH HOH A . 
C 3 HOH 18  418 10  HOH HOH A . 
C 3 HOH 19  419 28  HOH HOH A . 
C 3 HOH 20  420 91  HOH HOH A . 
C 3 HOH 21  421 21  HOH HOH A . 
C 3 HOH 22  422 88  HOH HOH A . 
C 3 HOH 23  423 87  HOH HOH A . 
C 3 HOH 24  424 48  HOH HOH A . 
C 3 HOH 25  425 44  HOH HOH A . 
C 3 HOH 26  426 56  HOH HOH A . 
C 3 HOH 27  427 38  HOH HOH A . 
C 3 HOH 28  428 6   HOH HOH A . 
C 3 HOH 29  429 64  HOH HOH A . 
C 3 HOH 30  430 7   HOH HOH A . 
C 3 HOH 31  431 70  HOH HOH A . 
C 3 HOH 32  432 30  HOH HOH A . 
C 3 HOH 33  433 22  HOH HOH A . 
C 3 HOH 34  434 62  HOH HOH A . 
C 3 HOH 35  435 5   HOH HOH A . 
C 3 HOH 36  436 9   HOH HOH A . 
C 3 HOH 37  437 50  HOH HOH A . 
C 3 HOH 38  438 3   HOH HOH A . 
C 3 HOH 39  439 24  HOH HOH A . 
C 3 HOH 40  440 23  HOH HOH A . 
C 3 HOH 41  441 32  HOH HOH A . 
C 3 HOH 42  442 65  HOH HOH A . 
C 3 HOH 43  443 16  HOH HOH A . 
C 3 HOH 44  444 52  HOH HOH A . 
C 3 HOH 45  445 40  HOH HOH A . 
C 3 HOH 46  446 63  HOH HOH A . 
C 3 HOH 47  447 27  HOH HOH A . 
C 3 HOH 48  448 68  HOH HOH A . 
C 3 HOH 49  449 78  HOH HOH A . 
C 3 HOH 50  450 53  HOH HOH A . 
C 3 HOH 51  451 11  HOH HOH A . 
C 3 HOH 52  452 35  HOH HOH A . 
C 3 HOH 53  453 92  HOH HOH A . 
C 3 HOH 54  454 106 HOH HOH A . 
C 3 HOH 55  455 66  HOH HOH A . 
C 3 HOH 56  456 33  HOH HOH A . 
C 3 HOH 57  457 1   HOH HOH A . 
C 3 HOH 58  458 77  HOH HOH A . 
C 3 HOH 59  459 51  HOH HOH A . 
C 3 HOH 60  460 79  HOH HOH A . 
C 3 HOH 61  461 37  HOH HOH A . 
C 3 HOH 62  462 19  HOH HOH A . 
C 3 HOH 63  463 45  HOH HOH A . 
C 3 HOH 64  464 18  HOH HOH A . 
C 3 HOH 65  465 4   HOH HOH A . 
C 3 HOH 66  466 14  HOH HOH A . 
C 3 HOH 67  467 67  HOH HOH A . 
C 3 HOH 68  468 13  HOH HOH A . 
C 3 HOH 69  469 96  HOH HOH A . 
C 3 HOH 70  470 15  HOH HOH A . 
C 3 HOH 71  471 41  HOH HOH A . 
C 3 HOH 72  472 8   HOH HOH A . 
C 3 HOH 73  473 76  HOH HOH A . 
C 3 HOH 74  474 104 HOH HOH A . 
C 3 HOH 75  475 58  HOH HOH A . 
C 3 HOH 76  476 25  HOH HOH A . 
C 3 HOH 77  477 54  HOH HOH A . 
C 3 HOH 78  478 109 HOH HOH A . 
C 3 HOH 79  479 2   HOH HOH A . 
C 3 HOH 80  480 31  HOH HOH A . 
C 3 HOH 81  481 84  HOH HOH A . 
C 3 HOH 82  482 57  HOH HOH A . 
C 3 HOH 83  483 20  HOH HOH A . 
C 3 HOH 84  484 36  HOH HOH A . 
C 3 HOH 85  485 17  HOH HOH A . 
C 3 HOH 86  486 82  HOH HOH A . 
C 3 HOH 87  487 80  HOH HOH A . 
C 3 HOH 88  488 46  HOH HOH A . 
C 3 HOH 89  489 55  HOH HOH A . 
C 3 HOH 90  490 94  HOH HOH A . 
C 3 HOH 91  491 49  HOH HOH A . 
C 3 HOH 92  492 83  HOH HOH A . 
C 3 HOH 93  493 61  HOH HOH A . 
C 3 HOH 94  494 111 HOH HOH A . 
C 3 HOH 95  495 60  HOH HOH A . 
C 3 HOH 96  496 89  HOH HOH A . 
C 3 HOH 97  497 59  HOH HOH A . 
C 3 HOH 98  498 47  HOH HOH A . 
C 3 HOH 99  499 34  HOH HOH A . 
C 3 HOH 100 500 74  HOH HOH A . 
C 3 HOH 101 501 105 HOH HOH A . 
C 3 HOH 102 502 110 HOH HOH A . 
C 3 HOH 103 503 29  HOH HOH A . 
C 3 HOH 104 504 93  HOH HOH A . 
C 3 HOH 105 505 112 HOH HOH A . 
C 3 HOH 106 506 43  HOH HOH A . 
C 3 HOH 107 507 114 HOH HOH A . 
C 3 HOH 108 508 85  HOH HOH A . 
C 3 HOH 109 509 99  HOH HOH A . 
C 3 HOH 110 510 98  HOH HOH A . 
C 3 HOH 111 511 113 HOH HOH A . 
C 3 HOH 112 512 97  HOH HOH A . 
C 3 HOH 113 513 81  HOH HOH A . 
C 3 HOH 114 514 86  HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? '(1.17.1_3660: ???)' 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? autoPROC ? ? ? .                    2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless  ? ? ? .                    3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER   ? ? ? .                    4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     8PVW 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     30.838 
_cell.length_a_esd                 ? 
_cell.length_b                     73.244 
_cell.length_b_esd                 ? 
_cell.length_c                     90.357 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         8PVW 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                18 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 2 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   8PVW 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.49 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          50 
_exptl_crystal.description                  Plate 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              8.0 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '30% PEG 4000, 0.2 M Ammonium sulfate' 
_exptl_crystal_grow.pdbx_pH_range   7.0-8.5 
_exptl_crystal_grow.temp            291 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 4M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-07-08 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.873 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'ESRF BEAMLINE ID30B' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.873 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ID30B 
_diffrn_source.pdbx_synchrotron_site       ESRF 
# 
_reflns.B_iso_Wilson_estimate                          18.36 
_reflns.entry_id                                       8PVW 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.7 
_reflns.d_resolution_low                               58.45 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     13571 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           78.7 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                10 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          12.4 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                0.036 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.988 
_reflns.pdbx_CC_star                                   0.988 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.092 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.955 
_reflns_shell.d_res_low                                     2.5 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             13571 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.988 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 8PVW 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.00 
_refine.ls_d_res_low                             38.45 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     12390 
_refine.ls_number_reflns_R_free                  620 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    85.50 
_refine.ls_percent_reflns_R_free                 5.00 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1859 
_refine.ls_R_factor_R_free                       0.2344 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1834 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.35 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.11 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 26.08 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.27 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.00 
_refine_hist.d_res_low                        38.45 
_refine_hist.number_atoms_solvent             114 
_refine_hist.number_atoms_total               1609 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1438 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         57 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.014  ? 1525 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.725  ? 2069 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 21.184 ? 238  ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.062  ? 232  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.008  ? 262  ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.00 2.20  . . 104 2031 60.00 . . . . 0.2413 . . . . . . . . . . . 0.2952 
'X-RAY DIFFRACTION' 2.20 2.52  . . 143 3087 91.00 . . . . 0.1986 . . . . . . . . . . . 0.2787 
'X-RAY DIFFRACTION' 2.52 3.17  . . 196 3288 97.00 . . . . 0.2003 . . . . . . . . . . . 0.2602 
'X-RAY DIFFRACTION' 3.17 38.45 . . 177 3365 94.00 . . . . 0.1641 . . . . . . . . . . . 0.2034 
# 
_struct.entry_id                     8PVW 
_struct.title                        'Structure of a short E. coli adenylate kinase in complex with Ap5A' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        8PVW 
_struct_keywords.text            'P-loop nucleotide/nucleoside kinase-like, SIGNALING PROTEIN' 
_struct_keywords.pdbx_keywords   'SIGNALING PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    PDB 
_struct_ref.db_code                    8PVW 
_struct_ref.pdbx_db_accession          8PVW 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   ? 
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              8PVW 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 187 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             8PVW 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  187 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       187 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 1390 ? 
1 MORE         -6   ? 
1 'SSA (A^2)'  9430 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'NMR Distance Restraints' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLY A 12  ? GLY A 25  ? GLY A 12  GLY A 25  1 ? 14 
HELX_P HELX_P2  AA2 THR A 31  ? GLY A 42  ? THR A 31  GLY A 42  1 ? 12 
HELX_P HELX_P3  AA3 GLN A 48  ? ALA A 55  ? GLN A 48  ALA A 55  1 ? 8  
HELX_P HELX_P4  AA4 THR A 60  ? ALA A 73  ? THR A 60  ALA A 73  1 ? 14 
HELX_P HELX_P5  AA5 GLN A 74  ? ARG A 78  ? GLN A 74  ARG A 78  5 ? 5  
HELX_P HELX_P6  AA6 THR A 89  ? ALA A 99  ? THR A 89  ALA A 99  1 ? 11 
HELX_P HELX_P7  AA7 PRO A 112 ? GLY A 128 ? PRO A 112 GLY A 128 1 ? 17 
HELX_P HELX_P8  AA8 ARG A 129 ? ASP A 132 ? ARG A 129 ASP A 132 5 ? 4  
HELX_P HELX_P9  AA9 ASN A 133 ? THR A 148 ? ASN A 133 THR A 148 1 ? 16 
HELX_P HELX_P10 AB1 ALA A 149 ? ALA A 161 ? ALA A 149 ALA A 161 1 ? 13 
HELX_P HELX_P11 AB2 PRO A 174 ? GLY A 187 ? PRO A 174 GLY A 187 1 ? 14 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          PHE 
_struct_mon_prot_cis.label_seq_id           86 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           PHE 
_struct_mon_prot_cis.auth_seq_id            86 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    87 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     87 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       -7.98 
# 
_struct_sheet.id               AA1 
_struct_sheet.type             ? 
_struct_sheet.number_strands   5 
_struct_sheet.details          ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel 
AA1 2 3 ? parallel 
AA1 3 4 ? parallel 
AA1 4 5 ? parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 GLN A 28  ? SER A 30  ? GLN A 28  SER A 30  
AA1 2 PHE A 81  ? ASP A 84  ? PHE A 81  ASP A 84  
AA1 3 ARG A 2   ? GLY A 7   ? ARG A 2   GLY A 7   
AA1 4 TYR A 105 ? ASP A 110 ? TYR A 105 ASP A 110 
AA1 5 LYS A 165 ? ASP A 170 ? LYS A 165 ASP A 170 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ILE A 29  ? N ILE A 29  O LEU A 82  ? O LEU A 82  
AA1 2 3 O LEU A 83  ? O LEU A 83  N ILE A 3   ? N ILE A 3   
AA1 3 4 N LEU A 6   ? N LEU A 6   O LEU A 107 ? O LEU A 107 
AA1 4 5 N GLU A 108 ? N GLU A 108 O ALA A 167 ? O ALA A 167 
# 
_pdbx_entry_details.entry_id                   8PVW 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
AP5 PA   P N S 14  
AP5 O1A  O N N 15  
AP5 O2A  O N N 16  
AP5 O3A  O N N 17  
AP5 PB   P N S 18  
AP5 O1B  O N N 19  
AP5 O2B  O N N 20  
AP5 O3B  O N N 21  
AP5 PG   P N N 22  
AP5 O1G  O N N 23  
AP5 O2G  O N N 24  
AP5 O3G  O N N 25  
AP5 PD   P N S 26  
AP5 O1D  O N N 27  
AP5 O2D  O N N 28  
AP5 O3D  O N N 29  
AP5 PE   P N S 30  
AP5 O1E  O N N 31  
AP5 O2E  O N N 32  
AP5 O5F  O N N 33  
AP5 C5F  C N N 34  
AP5 C4F  C N R 35  
AP5 O4F  O N N 36  
AP5 C3F  C N S 37  
AP5 O3F  O N N 38  
AP5 C2F  C N R 39  
AP5 O2F  O N N 40  
AP5 C1F  C N R 41  
AP5 N9A  N Y N 42  
AP5 C8A  C Y N 43  
AP5 N7A  N Y N 44  
AP5 C5A  C Y N 45  
AP5 C6A  C Y N 46  
AP5 N6A  N N N 47  
AP5 N1A  N Y N 48  
AP5 C2A  C Y N 49  
AP5 N3A  N Y N 50  
AP5 C4A  C Y N 51  
AP5 O5J  O N N 52  
AP5 C5J  C N N 53  
AP5 C4J  C N R 54  
AP5 O4J  O N N 55  
AP5 C3J  C N S 56  
AP5 O3J  O N N 57  
AP5 C2J  C N R 58  
AP5 O2J  O N N 59  
AP5 C1J  C N R 60  
AP5 N9B  N Y N 61  
AP5 C8B  C Y N 62  
AP5 N7B  N Y N 63  
AP5 C5B  C Y N 64  
AP5 C6B  C Y N 65  
AP5 N6B  N N N 66  
AP5 N1B  N Y N 67  
AP5 C2B  C Y N 68  
AP5 N3B  N Y N 69  
AP5 C4B  C Y N 70  
AP5 HOA2 H N N 71  
AP5 HOB2 H N N 72  
AP5 HOG2 H N N 73  
AP5 HOD2 H N N 74  
AP5 HOE2 H N N 75  
AP5 H51A H N N 76  
AP5 H52A H N N 77  
AP5 H4F  H N N 78  
AP5 H3F  H N N 79  
AP5 HO3A H N N 80  
AP5 H2F  H N N 81  
AP5 HO2A H N N 82  
AP5 H1F  H N N 83  
AP5 H8A  H N N 84  
AP5 H61A H N N 85  
AP5 H62A H N N 86  
AP5 H2A  H N N 87  
AP5 H51B H N N 88  
AP5 H52B H N N 89  
AP5 H4J  H N N 90  
AP5 H3J  H N N 91  
AP5 HO3B H N N 92  
AP5 H2J  H N N 93  
AP5 HO2B H N N 94  
AP5 H1J  H N N 95  
AP5 H8B  H N N 96  
AP5 H61B H N N 97  
AP5 H62B H N N 98  
AP5 H2B  H N N 99  
ARG N    N N N 100 
ARG CA   C N S 101 
ARG C    C N N 102 
ARG O    O N N 103 
ARG CB   C N N 104 
ARG CG   C N N 105 
ARG CD   C N N 106 
ARG NE   N N N 107 
ARG CZ   C N N 108 
ARG NH1  N N N 109 
ARG NH2  N N N 110 
ARG OXT  O N N 111 
ARG H    H N N 112 
ARG H2   H N N 113 
ARG HA   H N N 114 
ARG HB2  H N N 115 
ARG HB3  H N N 116 
ARG HG2  H N N 117 
ARG HG3  H N N 118 
ARG HD2  H N N 119 
ARG HD3  H N N 120 
ARG HE   H N N 121 
ARG HH11 H N N 122 
ARG HH12 H N N 123 
ARG HH21 H N N 124 
ARG HH22 H N N 125 
ARG HXT  H N N 126 
ASN N    N N N 127 
ASN CA   C N S 128 
ASN C    C N N 129 
ASN O    O N N 130 
ASN CB   C N N 131 
ASN CG   C N N 132 
ASN OD1  O N N 133 
ASN ND2  N N N 134 
ASN OXT  O N N 135 
ASN H    H N N 136 
ASN H2   H N N 137 
ASN HA   H N N 138 
ASN HB2  H N N 139 
ASN HB3  H N N 140 
ASN HD21 H N N 141 
ASN HD22 H N N 142 
ASN HXT  H N N 143 
ASP N    N N N 144 
ASP CA   C N S 145 
ASP C    C N N 146 
ASP O    O N N 147 
ASP CB   C N N 148 
ASP CG   C N N 149 
ASP OD1  O N N 150 
ASP OD2  O N N 151 
ASP OXT  O N N 152 
ASP H    H N N 153 
ASP H2   H N N 154 
ASP HA   H N N 155 
ASP HB2  H N N 156 
ASP HB3  H N N 157 
ASP HD2  H N N 158 
ASP HXT  H N N 159 
CYS N    N N N 160 
CYS CA   C N R 161 
CYS C    C N N 162 
CYS O    O N N 163 
CYS CB   C N N 164 
CYS SG   S N N 165 
CYS OXT  O N N 166 
CYS H    H N N 167 
CYS H2   H N N 168 
CYS HA   H N N 169 
CYS HB2  H N N 170 
CYS HB3  H N N 171 
CYS HG   H N N 172 
CYS HXT  H N N 173 
GLN N    N N N 174 
GLN CA   C N S 175 
GLN C    C N N 176 
GLN O    O N N 177 
GLN CB   C N N 178 
GLN CG   C N N 179 
GLN CD   C N N 180 
GLN OE1  O N N 181 
GLN NE2  N N N 182 
GLN OXT  O N N 183 
GLN H    H N N 184 
GLN H2   H N N 185 
GLN HA   H N N 186 
GLN HB2  H N N 187 
GLN HB3  H N N 188 
GLN HG2  H N N 189 
GLN HG3  H N N 190 
GLN HE21 H N N 191 
GLN HE22 H N N 192 
GLN HXT  H N N 193 
GLU N    N N N 194 
GLU CA   C N S 195 
GLU C    C N N 196 
GLU O    O N N 197 
GLU CB   C N N 198 
GLU CG   C N N 199 
GLU CD   C N N 200 
GLU OE1  O N N 201 
GLU OE2  O N N 202 
GLU OXT  O N N 203 
GLU H    H N N 204 
GLU H2   H N N 205 
GLU HA   H N N 206 
GLU HB2  H N N 207 
GLU HB3  H N N 208 
GLU HG2  H N N 209 
GLU HG3  H N N 210 
GLU HE2  H N N 211 
GLU HXT  H N N 212 
GLY N    N N N 213 
GLY CA   C N N 214 
GLY C    C N N 215 
GLY O    O N N 216 
GLY OXT  O N N 217 
GLY H    H N N 218 
GLY H2   H N N 219 
GLY HA2  H N N 220 
GLY HA3  H N N 221 
GLY HXT  H N N 222 
HIS N    N N N 223 
HIS CA   C N S 224 
HIS C    C N N 225 
HIS O    O N N 226 
HIS CB   C N N 227 
HIS CG   C Y N 228 
HIS ND1  N Y N 229 
HIS CD2  C Y N 230 
HIS CE1  C Y N 231 
HIS NE2  N Y N 232 
HIS OXT  O N N 233 
HIS H    H N N 234 
HIS H2   H N N 235 
HIS HA   H N N 236 
HIS HB2  H N N 237 
HIS HB3  H N N 238 
HIS HD1  H N N 239 
HIS HD2  H N N 240 
HIS HE1  H N N 241 
HIS HE2  H N N 242 
HIS HXT  H N N 243 
HOH O    O N N 244 
HOH H1   H N N 245 
HOH H2   H N N 246 
ILE N    N N N 247 
ILE CA   C N S 248 
ILE C    C N N 249 
ILE O    O N N 250 
ILE CB   C N S 251 
ILE CG1  C N N 252 
ILE CG2  C N N 253 
ILE CD1  C N N 254 
ILE OXT  O N N 255 
ILE H    H N N 256 
ILE H2   H N N 257 
ILE HA   H N N 258 
ILE HB   H N N 259 
ILE HG12 H N N 260 
ILE HG13 H N N 261 
ILE HG21 H N N 262 
ILE HG22 H N N 263 
ILE HG23 H N N 264 
ILE HD11 H N N 265 
ILE HD12 H N N 266 
ILE HD13 H N N 267 
ILE HXT  H N N 268 
LEU N    N N N 269 
LEU CA   C N S 270 
LEU C    C N N 271 
LEU O    O N N 272 
LEU CB   C N N 273 
LEU CG   C N N 274 
LEU CD1  C N N 275 
LEU CD2  C N N 276 
LEU OXT  O N N 277 
LEU H    H N N 278 
LEU H2   H N N 279 
LEU HA   H N N 280 
LEU HB2  H N N 281 
LEU HB3  H N N 282 
LEU HG   H N N 283 
LEU HD11 H N N 284 
LEU HD12 H N N 285 
LEU HD13 H N N 286 
LEU HD21 H N N 287 
LEU HD22 H N N 288 
LEU HD23 H N N 289 
LEU HXT  H N N 290 
LYS N    N N N 291 
LYS CA   C N S 292 
LYS C    C N N 293 
LYS O    O N N 294 
LYS CB   C N N 295 
LYS CG   C N N 296 
LYS CD   C N N 297 
LYS CE   C N N 298 
LYS NZ   N N N 299 
LYS OXT  O N N 300 
LYS H    H N N 301 
LYS H2   H N N 302 
LYS HA   H N N 303 
LYS HB2  H N N 304 
LYS HB3  H N N 305 
LYS HG2  H N N 306 
LYS HG3  H N N 307 
LYS HD2  H N N 308 
LYS HD3  H N N 309 
LYS HE2  H N N 310 
LYS HE3  H N N 311 
LYS HZ1  H N N 312 
LYS HZ2  H N N 313 
LYS HZ3  H N N 314 
LYS HXT  H N N 315 
MET N    N N N 316 
MET CA   C N S 317 
MET C    C N N 318 
MET O    O N N 319 
MET CB   C N N 320 
MET CG   C N N 321 
MET SD   S N N 322 
MET CE   C N N 323 
MET OXT  O N N 324 
MET H    H N N 325 
MET H2   H N N 326 
MET HA   H N N 327 
MET HB2  H N N 328 
MET HB3  H N N 329 
MET HG2  H N N 330 
MET HG3  H N N 331 
MET HE1  H N N 332 
MET HE2  H N N 333 
MET HE3  H N N 334 
MET HXT  H N N 335 
PHE N    N N N 336 
PHE CA   C N S 337 
PHE C    C N N 338 
PHE O    O N N 339 
PHE CB   C N N 340 
PHE CG   C Y N 341 
PHE CD1  C Y N 342 
PHE CD2  C Y N 343 
PHE CE1  C Y N 344 
PHE CE2  C Y N 345 
PHE CZ   C Y N 346 
PHE OXT  O N N 347 
PHE H    H N N 348 
PHE H2   H N N 349 
PHE HA   H N N 350 
PHE HB2  H N N 351 
PHE HB3  H N N 352 
PHE HD1  H N N 353 
PHE HD2  H N N 354 
PHE HE1  H N N 355 
PHE HE2  H N N 356 
PHE HZ   H N N 357 
PHE HXT  H N N 358 
PRO N    N N N 359 
PRO CA   C N S 360 
PRO C    C N N 361 
PRO O    O N N 362 
PRO CB   C N N 363 
PRO CG   C N N 364 
PRO CD   C N N 365 
PRO OXT  O N N 366 
PRO H    H N N 367 
PRO HA   H N N 368 
PRO HB2  H N N 369 
PRO HB3  H N N 370 
PRO HG2  H N N 371 
PRO HG3  H N N 372 
PRO HD2  H N N 373 
PRO HD3  H N N 374 
PRO HXT  H N N 375 
SER N    N N N 376 
SER CA   C N S 377 
SER C    C N N 378 
SER O    O N N 379 
SER CB   C N N 380 
SER OG   O N N 381 
SER OXT  O N N 382 
SER H    H N N 383 
SER H2   H N N 384 
SER HA   H N N 385 
SER HB2  H N N 386 
SER HB3  H N N 387 
SER HG   H N N 388 
SER HXT  H N N 389 
THR N    N N N 390 
THR CA   C N S 391 
THR C    C N N 392 
THR O    O N N 393 
THR CB   C N R 394 
THR OG1  O N N 395 
THR CG2  C N N 396 
THR OXT  O N N 397 
THR H    H N N 398 
THR H2   H N N 399 
THR HA   H N N 400 
THR HB   H N N 401 
THR HG1  H N N 402 
THR HG21 H N N 403 
THR HG22 H N N 404 
THR HG23 H N N 405 
THR HXT  H N N 406 
TYR N    N N N 407 
TYR CA   C N S 408 
TYR C    C N N 409 
TYR O    O N N 410 
TYR CB   C N N 411 
TYR CG   C Y N 412 
TYR CD1  C Y N 413 
TYR CD2  C Y N 414 
TYR CE1  C Y N 415 
TYR CE2  C Y N 416 
TYR CZ   C Y N 417 
TYR OH   O N N 418 
TYR OXT  O N N 419 
TYR H    H N N 420 
TYR H2   H N N 421 
TYR HA   H N N 422 
TYR HB2  H N N 423 
TYR HB3  H N N 424 
TYR HD1  H N N 425 
TYR HD2  H N N 426 
TYR HE1  H N N 427 
TYR HE2  H N N 428 
TYR HH   H N N 429 
TYR HXT  H N N 430 
VAL N    N N N 431 
VAL CA   C N S 432 
VAL C    C N N 433 
VAL O    O N N 434 
VAL CB   C N N 435 
VAL CG1  C N N 436 
VAL CG2  C N N 437 
VAL OXT  O N N 438 
VAL H    H N N 439 
VAL H2   H N N 440 
VAL HA   H N N 441 
VAL HB   H N N 442 
VAL HG11 H N N 443 
VAL HG12 H N N 444 
VAL HG13 H N N 445 
VAL HG21 H N N 446 
VAL HG22 H N N 447 
VAL HG23 H N N 448 
VAL HXT  H N N 449 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
AP5 PA  O1A  doub N N 13  
AP5 PA  O2A  sing N N 14  
AP5 PA  O3A  sing N N 15  
AP5 PA  O5F  sing N N 16  
AP5 O2A HOA2 sing N N 17  
AP5 O3A PB   sing N N 18  
AP5 PB  O1B  doub N N 19  
AP5 PB  O2B  sing N N 20  
AP5 PB  O3B  sing N N 21  
AP5 O2B HOB2 sing N N 22  
AP5 O3B PG   sing N N 23  
AP5 PG  O1G  doub N N 24  
AP5 PG  O2G  sing N N 25  
AP5 PG  O3G  sing N N 26  
AP5 O2G HOG2 sing N N 27  
AP5 O3G PD   sing N N 28  
AP5 PD  O1D  doub N N 29  
AP5 PD  O2D  sing N N 30  
AP5 PD  O3D  sing N N 31  
AP5 O2D HOD2 sing N N 32  
AP5 O3D PE   sing N N 33  
AP5 PE  O1E  doub N N 34  
AP5 PE  O2E  sing N N 35  
AP5 PE  O5J  sing N N 36  
AP5 O2E HOE2 sing N N 37  
AP5 O5F C5F  sing N N 38  
AP5 C5F C4F  sing N N 39  
AP5 C5F H51A sing N N 40  
AP5 C5F H52A sing N N 41  
AP5 C4F O4F  sing N N 42  
AP5 C4F C3F  sing N N 43  
AP5 C4F H4F  sing N N 44  
AP5 O4F C1F  sing N N 45  
AP5 C3F O3F  sing N N 46  
AP5 C3F C2F  sing N N 47  
AP5 C3F H3F  sing N N 48  
AP5 O3F HO3A sing N N 49  
AP5 C2F O2F  sing N N 50  
AP5 C2F C1F  sing N N 51  
AP5 C2F H2F  sing N N 52  
AP5 O2F HO2A sing N N 53  
AP5 C1F N9A  sing N N 54  
AP5 C1F H1F  sing N N 55  
AP5 N9A C8A  sing Y N 56  
AP5 N9A C4A  sing Y N 57  
AP5 C8A N7A  doub Y N 58  
AP5 C8A H8A  sing N N 59  
AP5 N7A C5A  sing Y N 60  
AP5 C5A C6A  sing Y N 61  
AP5 C5A C4A  doub Y N 62  
AP5 C6A N6A  sing N N 63  
AP5 C6A N1A  doub Y N 64  
AP5 N6A H61A sing N N 65  
AP5 N6A H62A sing N N 66  
AP5 N1A C2A  sing Y N 67  
AP5 C2A N3A  doub Y N 68  
AP5 C2A H2A  sing N N 69  
AP5 N3A C4A  sing Y N 70  
AP5 O5J C5J  sing N N 71  
AP5 C5J C4J  sing N N 72  
AP5 C5J H51B sing N N 73  
AP5 C5J H52B sing N N 74  
AP5 C4J O4J  sing N N 75  
AP5 C4J C3J  sing N N 76  
AP5 C4J H4J  sing N N 77  
AP5 O4J C1J  sing N N 78  
AP5 C3J O3J  sing N N 79  
AP5 C3J C2J  sing N N 80  
AP5 C3J H3J  sing N N 81  
AP5 O3J HO3B sing N N 82  
AP5 C2J O2J  sing N N 83  
AP5 C2J C1J  sing N N 84  
AP5 C2J H2J  sing N N 85  
AP5 O2J HO2B sing N N 86  
AP5 C1J N9B  sing N N 87  
AP5 C1J H1J  sing N N 88  
AP5 N9B C8B  sing Y N 89  
AP5 N9B C4B  sing Y N 90  
AP5 C8B N7B  doub Y N 91  
AP5 C8B H8B  sing N N 92  
AP5 N7B C5B  sing Y N 93  
AP5 C5B C6B  sing Y N 94  
AP5 C5B C4B  doub Y N 95  
AP5 C6B N6B  sing N N 96  
AP5 C6B N1B  doub Y N 97  
AP5 N6B H61B sing N N 98  
AP5 N6B H62B sing N N 99  
AP5 N1B C2B  sing Y N 100 
AP5 C2B N3B  doub Y N 101 
AP5 C2B H2B  sing N N 102 
AP5 N3B C4B  sing Y N 103 
ARG N   CA   sing N N 104 
ARG N   H    sing N N 105 
ARG N   H2   sing N N 106 
ARG CA  C    sing N N 107 
ARG CA  CB   sing N N 108 
ARG CA  HA   sing N N 109 
ARG C   O    doub N N 110 
ARG C   OXT  sing N N 111 
ARG CB  CG   sing N N 112 
ARG CB  HB2  sing N N 113 
ARG CB  HB3  sing N N 114 
ARG CG  CD   sing N N 115 
ARG CG  HG2  sing N N 116 
ARG CG  HG3  sing N N 117 
ARG CD  NE   sing N N 118 
ARG CD  HD2  sing N N 119 
ARG CD  HD3  sing N N 120 
ARG NE  CZ   sing N N 121 
ARG NE  HE   sing N N 122 
ARG CZ  NH1  sing N N 123 
ARG CZ  NH2  doub N N 124 
ARG NH1 HH11 sing N N 125 
ARG NH1 HH12 sing N N 126 
ARG NH2 HH21 sing N N 127 
ARG NH2 HH22 sing N N 128 
ARG OXT HXT  sing N N 129 
ASN N   CA   sing N N 130 
ASN N   H    sing N N 131 
ASN N   H2   sing N N 132 
ASN CA  C    sing N N 133 
ASN CA  CB   sing N N 134 
ASN CA  HA   sing N N 135 
ASN C   O    doub N N 136 
ASN C   OXT  sing N N 137 
ASN CB  CG   sing N N 138 
ASN CB  HB2  sing N N 139 
ASN CB  HB3  sing N N 140 
ASN CG  OD1  doub N N 141 
ASN CG  ND2  sing N N 142 
ASN ND2 HD21 sing N N 143 
ASN ND2 HD22 sing N N 144 
ASN OXT HXT  sing N N 145 
ASP N   CA   sing N N 146 
ASP N   H    sing N N 147 
ASP N   H2   sing N N 148 
ASP CA  C    sing N N 149 
ASP CA  CB   sing N N 150 
ASP CA  HA   sing N N 151 
ASP C   O    doub N N 152 
ASP C   OXT  sing N N 153 
ASP CB  CG   sing N N 154 
ASP CB  HB2  sing N N 155 
ASP CB  HB3  sing N N 156 
ASP CG  OD1  doub N N 157 
ASP CG  OD2  sing N N 158 
ASP OD2 HD2  sing N N 159 
ASP OXT HXT  sing N N 160 
CYS N   CA   sing N N 161 
CYS N   H    sing N N 162 
CYS N   H2   sing N N 163 
CYS CA  C    sing N N 164 
CYS CA  CB   sing N N 165 
CYS CA  HA   sing N N 166 
CYS C   O    doub N N 167 
CYS C   OXT  sing N N 168 
CYS CB  SG   sing N N 169 
CYS CB  HB2  sing N N 170 
CYS CB  HB3  sing N N 171 
CYS SG  HG   sing N N 172 
CYS OXT HXT  sing N N 173 
GLN N   CA   sing N N 174 
GLN N   H    sing N N 175 
GLN N   H2   sing N N 176 
GLN CA  C    sing N N 177 
GLN CA  CB   sing N N 178 
GLN CA  HA   sing N N 179 
GLN C   O    doub N N 180 
GLN C   OXT  sing N N 181 
GLN CB  CG   sing N N 182 
GLN CB  HB2  sing N N 183 
GLN CB  HB3  sing N N 184 
GLN CG  CD   sing N N 185 
GLN CG  HG2  sing N N 186 
GLN CG  HG3  sing N N 187 
GLN CD  OE1  doub N N 188 
GLN CD  NE2  sing N N 189 
GLN NE2 HE21 sing N N 190 
GLN NE2 HE22 sing N N 191 
GLN OXT HXT  sing N N 192 
GLU N   CA   sing N N 193 
GLU N   H    sing N N 194 
GLU N   H2   sing N N 195 
GLU CA  C    sing N N 196 
GLU CA  CB   sing N N 197 
GLU CA  HA   sing N N 198 
GLU C   O    doub N N 199 
GLU C   OXT  sing N N 200 
GLU CB  CG   sing N N 201 
GLU CB  HB2  sing N N 202 
GLU CB  HB3  sing N N 203 
GLU CG  CD   sing N N 204 
GLU CG  HG2  sing N N 205 
GLU CG  HG3  sing N N 206 
GLU CD  OE1  doub N N 207 
GLU CD  OE2  sing N N 208 
GLU OE2 HE2  sing N N 209 
GLU OXT HXT  sing N N 210 
GLY N   CA   sing N N 211 
GLY N   H    sing N N 212 
GLY N   H2   sing N N 213 
GLY CA  C    sing N N 214 
GLY CA  HA2  sing N N 215 
GLY CA  HA3  sing N N 216 
GLY C   O    doub N N 217 
GLY C   OXT  sing N N 218 
GLY OXT HXT  sing N N 219 
HIS N   CA   sing N N 220 
HIS N   H    sing N N 221 
HIS N   H2   sing N N 222 
HIS CA  C    sing N N 223 
HIS CA  CB   sing N N 224 
HIS CA  HA   sing N N 225 
HIS C   O    doub N N 226 
HIS C   OXT  sing N N 227 
HIS CB  CG   sing N N 228 
HIS CB  HB2  sing N N 229 
HIS CB  HB3  sing N N 230 
HIS CG  ND1  sing Y N 231 
HIS CG  CD2  doub Y N 232 
HIS ND1 CE1  doub Y N 233 
HIS ND1 HD1  sing N N 234 
HIS CD2 NE2  sing Y N 235 
HIS CD2 HD2  sing N N 236 
HIS CE1 NE2  sing Y N 237 
HIS CE1 HE1  sing N N 238 
HIS NE2 HE2  sing N N 239 
HIS OXT HXT  sing N N 240 
HOH O   H1   sing N N 241 
HOH O   H2   sing N N 242 
ILE N   CA   sing N N 243 
ILE N   H    sing N N 244 
ILE N   H2   sing N N 245 
ILE CA  C    sing N N 246 
ILE CA  CB   sing N N 247 
ILE CA  HA   sing N N 248 
ILE C   O    doub N N 249 
ILE C   OXT  sing N N 250 
ILE CB  CG1  sing N N 251 
ILE CB  CG2  sing N N 252 
ILE CB  HB   sing N N 253 
ILE CG1 CD1  sing N N 254 
ILE CG1 HG12 sing N N 255 
ILE CG1 HG13 sing N N 256 
ILE CG2 HG21 sing N N 257 
ILE CG2 HG22 sing N N 258 
ILE CG2 HG23 sing N N 259 
ILE CD1 HD11 sing N N 260 
ILE CD1 HD12 sing N N 261 
ILE CD1 HD13 sing N N 262 
ILE OXT HXT  sing N N 263 
LEU N   CA   sing N N 264 
LEU N   H    sing N N 265 
LEU N   H2   sing N N 266 
LEU CA  C    sing N N 267 
LEU CA  CB   sing N N 268 
LEU CA  HA   sing N N 269 
LEU C   O    doub N N 270 
LEU C   OXT  sing N N 271 
LEU CB  CG   sing N N 272 
LEU CB  HB2  sing N N 273 
LEU CB  HB3  sing N N 274 
LEU CG  CD1  sing N N 275 
LEU CG  CD2  sing N N 276 
LEU CG  HG   sing N N 277 
LEU CD1 HD11 sing N N 278 
LEU CD1 HD12 sing N N 279 
LEU CD1 HD13 sing N N 280 
LEU CD2 HD21 sing N N 281 
LEU CD2 HD22 sing N N 282 
LEU CD2 HD23 sing N N 283 
LEU OXT HXT  sing N N 284 
LYS N   CA   sing N N 285 
LYS N   H    sing N N 286 
LYS N   H2   sing N N 287 
LYS CA  C    sing N N 288 
LYS CA  CB   sing N N 289 
LYS CA  HA   sing N N 290 
LYS C   O    doub N N 291 
LYS C   OXT  sing N N 292 
LYS CB  CG   sing N N 293 
LYS CB  HB2  sing N N 294 
LYS CB  HB3  sing N N 295 
LYS CG  CD   sing N N 296 
LYS CG  HG2  sing N N 297 
LYS CG  HG3  sing N N 298 
LYS CD  CE   sing N N 299 
LYS CD  HD2  sing N N 300 
LYS CD  HD3  sing N N 301 
LYS CE  NZ   sing N N 302 
LYS CE  HE2  sing N N 303 
LYS CE  HE3  sing N N 304 
LYS NZ  HZ1  sing N N 305 
LYS NZ  HZ2  sing N N 306 
LYS NZ  HZ3  sing N N 307 
LYS OXT HXT  sing N N 308 
MET N   CA   sing N N 309 
MET N   H    sing N N 310 
MET N   H2   sing N N 311 
MET CA  C    sing N N 312 
MET CA  CB   sing N N 313 
MET CA  HA   sing N N 314 
MET C   O    doub N N 315 
MET C   OXT  sing N N 316 
MET CB  CG   sing N N 317 
MET CB  HB2  sing N N 318 
MET CB  HB3  sing N N 319 
MET CG  SD   sing N N 320 
MET CG  HG2  sing N N 321 
MET CG  HG3  sing N N 322 
MET SD  CE   sing N N 323 
MET CE  HE1  sing N N 324 
MET CE  HE2  sing N N 325 
MET CE  HE3  sing N N 326 
MET OXT HXT  sing N N 327 
PHE N   CA   sing N N 328 
PHE N   H    sing N N 329 
PHE N   H2   sing N N 330 
PHE CA  C    sing N N 331 
PHE CA  CB   sing N N 332 
PHE CA  HA   sing N N 333 
PHE C   O    doub N N 334 
PHE C   OXT  sing N N 335 
PHE CB  CG   sing N N 336 
PHE CB  HB2  sing N N 337 
PHE CB  HB3  sing N N 338 
PHE CG  CD1  doub Y N 339 
PHE CG  CD2  sing Y N 340 
PHE CD1 CE1  sing Y N 341 
PHE CD1 HD1  sing N N 342 
PHE CD2 CE2  doub Y N 343 
PHE CD2 HD2  sing N N 344 
PHE CE1 CZ   doub Y N 345 
PHE CE1 HE1  sing N N 346 
PHE CE2 CZ   sing Y N 347 
PHE CE2 HE2  sing N N 348 
PHE CZ  HZ   sing N N 349 
PHE OXT HXT  sing N N 350 
PRO N   CA   sing N N 351 
PRO N   CD   sing N N 352 
PRO N   H    sing N N 353 
PRO CA  C    sing N N 354 
PRO CA  CB   sing N N 355 
PRO CA  HA   sing N N 356 
PRO C   O    doub N N 357 
PRO C   OXT  sing N N 358 
PRO CB  CG   sing N N 359 
PRO CB  HB2  sing N N 360 
PRO CB  HB3  sing N N 361 
PRO CG  CD   sing N N 362 
PRO CG  HG2  sing N N 363 
PRO CG  HG3  sing N N 364 
PRO CD  HD2  sing N N 365 
PRO CD  HD3  sing N N 366 
PRO OXT HXT  sing N N 367 
SER N   CA   sing N N 368 
SER N   H    sing N N 369 
SER N   H2   sing N N 370 
SER CA  C    sing N N 371 
SER CA  CB   sing N N 372 
SER CA  HA   sing N N 373 
SER C   O    doub N N 374 
SER C   OXT  sing N N 375 
SER CB  OG   sing N N 376 
SER CB  HB2  sing N N 377 
SER CB  HB3  sing N N 378 
SER OG  HG   sing N N 379 
SER OXT HXT  sing N N 380 
THR N   CA   sing N N 381 
THR N   H    sing N N 382 
THR N   H2   sing N N 383 
THR CA  C    sing N N 384 
THR CA  CB   sing N N 385 
THR CA  HA   sing N N 386 
THR C   O    doub N N 387 
THR C   OXT  sing N N 388 
THR CB  OG1  sing N N 389 
THR CB  CG2  sing N N 390 
THR CB  HB   sing N N 391 
THR OG1 HG1  sing N N 392 
THR CG2 HG21 sing N N 393 
THR CG2 HG22 sing N N 394 
THR CG2 HG23 sing N N 395 
THR OXT HXT  sing N N 396 
TYR N   CA   sing N N 397 
TYR N   H    sing N N 398 
TYR N   H2   sing N N 399 
TYR CA  C    sing N N 400 
TYR CA  CB   sing N N 401 
TYR CA  HA   sing N N 402 
TYR C   O    doub N N 403 
TYR C   OXT  sing N N 404 
TYR CB  CG   sing N N 405 
TYR CB  HB2  sing N N 406 
TYR CB  HB3  sing N N 407 
TYR CG  CD1  doub Y N 408 
TYR CG  CD2  sing Y N 409 
TYR CD1 CE1  sing Y N 410 
TYR CD1 HD1  sing N N 411 
TYR CD2 CE2  doub Y N 412 
TYR CD2 HD2  sing N N 413 
TYR CE1 CZ   doub Y N 414 
TYR CE1 HE1  sing N N 415 
TYR CE2 CZ   sing Y N 416 
TYR CE2 HE2  sing N N 417 
TYR CZ  OH   sing N N 418 
TYR OH  HH   sing N N 419 
TYR OXT HXT  sing N N 420 
VAL N   CA   sing N N 421 
VAL N   H    sing N N 422 
VAL N   H2   sing N N 423 
VAL CA  C    sing N N 424 
VAL CA  CB   sing N N 425 
VAL CA  HA   sing N N 426 
VAL C   O    doub N N 427 
VAL C   OXT  sing N N 428 
VAL CB  CG1  sing N N 429 
VAL CB  CG2  sing N N 430 
VAL CB  HB   sing N N 431 
VAL CG1 HG11 sing N N 432 
VAL CG1 HG12 sing N N 433 
VAL CG1 HG13 sing N N 434 
VAL CG2 HG21 sing N N 435 
VAL CG2 HG22 sing N N 436 
VAL CG2 HG23 sing N N 437 
VAL OXT HXT  sing N N 438 
# 
_pdbx_audit_support.funding_organization   'Swedish Research Council' 
_pdbx_audit_support.country                Sweden 
_pdbx_audit_support.grant_number           2021-04513_VR 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   83 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   4x8L 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    8PVW 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.032428 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.013653 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.011067 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.pdbx_scat_Z 
_atom_type.pdbx_N_electrons 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
C  6  6  2.3103  20.8439 1.0201 10.2075 1.5888 0.5687  0.8651 51.6512 0.2156   
MG 12 12 5.4265  2.8275  2.1759 79.2611 1.2283 0.3808  2.3099 7.1937  0.9187   
N  7  7  12.2220 0.0057  3.1346 9.8933  2.0141 28.9975 1.1672 0.5826  -11.5379 
O  8  8  3.0487  13.2771 2.2870 5.7011  1.5464 0.3239  0.8671 32.9089 0.2508   
P  15 15 6.4348  1.9067  4.1793 27.1570 1.7801 0.5260  1.4909 68.1645 1.2401   
S  16 16 6.9054  1.4679  5.2035 22.2151 1.4379 0.2536  1.5863 56.1720 1.0182   
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
_atom_site.calc_flag 
ATOM   1    N N   . MET A 1 1   ? -1.752  -16.068 3.264  1.00 54.74  ? 1   MET A N   1 ? 
ATOM   2    C CA  . MET A 1 1   ? -2.449  -17.240 3.852  1.00 32.27  ? 1   MET A CA  1 ? 
ATOM   3    C C   . MET A 1 1   ? -3.192  -16.884 5.122  1.00 25.41  ? 1   MET A C   1 ? 
ATOM   4    O O   . MET A 1 1   ? -2.605  -16.722 6.192  1.00 27.54  ? 1   MET A O   1 ? 
ATOM   5    C CB  . MET A 1 1   ? -1.473  -18.325 4.142  1.00 34.49  ? 1   MET A CB  1 ? 
ATOM   6    C CG  . MET A 1 1   ? -2.089  -19.570 4.713  1.00 40.18  ? 1   MET A CG  1 ? 
ATOM   7    S SD  . MET A 1 1   ? -3.404  -20.256 3.692  1.00 55.65  ? 1   MET A SD  1 ? 
ATOM   8    C CE  . MET A 1 1   ? -2.994  -21.986 3.893  1.00 51.45  ? 1   MET A CE  1 ? 
ATOM   9    N N   . ARG A 1 2   ? -4.494  -16.803 4.982  1.00 25.14  ? 2   ARG A N   1 ? 
ATOM   10   C CA  . ARG A 1 2   ? -5.372  -16.377 6.047  1.00 19.11  ? 2   ARG A CA  1 ? 
ATOM   11   C C   . ARG A 1 2   ? -6.370  -17.485 6.324  1.00 23.35  ? 2   ARG A C   1 ? 
ATOM   12   O O   . ARG A 1 2   ? -7.065  -17.963 5.424  1.00 23.00  ? 2   ARG A O   1 ? 
ATOM   13   C CB  . ARG A 1 2   ? -6.066  -15.074 5.670  1.00 30.06  ? 2   ARG A CB  1 ? 
ATOM   14   C CG  . ARG A 1 2   ? -5.089  -14.031 5.079  1.00 45.40  ? 2   ARG A CG  1 ? 
ATOM   15   C CD  . ARG A 1 2   ? -5.822  -12.850 4.426  1.00 58.02  ? 2   ARG A CD  1 ? 
ATOM   16   N NE  . ARG A 1 2   ? -5.426  -12.504 3.044  1.00 84.43  ? 2   ARG A NE  1 ? 
ATOM   17   C CZ  . ARG A 1 2   ? -5.981  -12.982 1.921  1.00 90.24  ? 2   ARG A CZ  1 ? 
ATOM   18   N NH1 . ARG A 1 2   ? -6.949  -13.887 1.956  1.00 82.12  ? 2   ARG A NH1 1 ? 
ATOM   19   N NH2 . ARG A 1 2   ? -5.551  -12.558 0.744  1.00 68.99  ? 2   ARG A NH2 1 ? 
ATOM   20   N N   . ILE A 1 3   ? -6.442  -17.874 7.573  1.00 15.98  ? 3   ILE A N   1 ? 
ATOM   21   C CA  . ILE A 1 3   ? -7.198  -19.042 8.010  1.00 12.64  ? 3   ILE A CA  1 ? 
ATOM   22   C C   . ILE A 1 3   ? -8.033  -18.671 9.222  1.00 15.06  ? 3   ILE A C   1 ? 
ATOM   23   O O   . ILE A 1 3   ? -7.558  -17.983 10.133 1.00 22.77  ? 3   ILE A O   1 ? 
ATOM   24   C CB  . ILE A 1 3   ? -6.263  -20.211 8.356  1.00 22.15  ? 3   ILE A CB  1 ? 
ATOM   25   C CG1 . ILE A 1 3   ? -5.610  -20.801 7.088  1.00 19.00  ? 3   ILE A CG1 1 ? 
ATOM   26   C CG2 . ILE A 1 3   ? -7.016  -21.242 9.135  1.00 19.22  ? 3   ILE A CG2 1 ? 
ATOM   27   C CD1 . ILE A 1 3   ? -4.415  -21.588 7.436  1.00 29.07  ? 3   ILE A CD1 1 ? 
ATOM   28   N N   . ILE A 1 4   ? -9.273  -19.123 9.224  1.00 14.46  ? 4   ILE A N   1 ? 
ATOM   29   C CA  . ILE A 1 4   ? -10.171 -19.010 10.360 1.00 18.71  ? 4   ILE A CA  1 ? 
ATOM   30   C C   . ILE A 1 4   ? -10.385 -20.410 10.927 1.00 22.48  ? 4   ILE A C   1 ? 
ATOM   31   O O   . ILE A 1 4   ? -10.733 -21.345 10.195 1.00 18.32  ? 4   ILE A O   1 ? 
ATOM   32   C CB  . ILE A 1 4   ? -11.527 -18.416 9.943  1.00 18.16  ? 4   ILE A CB  1 ? 
ATOM   33   C CG1 . ILE A 1 4   ? -11.408 -16.997 9.429  1.00 19.30  ? 4   ILE A CG1 1 ? 
ATOM   34   C CG2 . ILE A 1 4   ? -12.506 -18.463 11.092 1.00 22.31  ? 4   ILE A CG2 1 ? 
ATOM   35   C CD1 . ILE A 1 4   ? -12.775 -16.424 8.960  1.00 20.17  ? 4   ILE A CD1 1 ? 
ATOM   36   N N   . LEU A 1 5   ? -10.300 -20.574 12.247 1.00 22.00  ? 5   LEU A N   1 ? 
ATOM   37   C CA  . LEU A 1 5   ? -10.603 -21.842 12.944 1.00 21.43  ? 5   LEU A CA  1 ? 
ATOM   38   C C   . LEU A 1 5   ? -11.952 -21.661 13.660 1.00 22.98  ? 5   LEU A C   1 ? 
ATOM   39   O O   . LEU A 1 5   ? -12.021 -20.801 14.521 1.00 24.19  ? 5   LEU A O   1 ? 
ATOM   40   C CB  . LEU A 1 5   ? -9.508  -22.156 13.965 1.00 19.80  ? 5   LEU A CB  1 ? 
ATOM   41   C CG  . LEU A 1 5   ? -8.089  -22.310 13.440 1.00 19.68  ? 5   LEU A CG  1 ? 
ATOM   42   C CD1 . LEU A 1 5   ? -7.169  -22.773 14.550 1.00 24.05  ? 5   LEU A CD1 1 ? 
ATOM   43   C CD2 . LEU A 1 5   ? -8.046  -23.268 12.272 1.00 25.16  ? 5   LEU A CD2 1 ? 
ATOM   44   N N   . LEU A 1 6   ? -12.993 -22.390 13.288 1.00 19.07  ? 6   LEU A N   1 ? 
ATOM   45   C CA  . LEU A 1 6   ? -14.323 -22.343 13.935 1.00 21.49  ? 6   LEU A CA  1 ? 
ATOM   46   C C   . LEU A 1 6   ? -14.531 -23.575 14.811 1.00 20.22  ? 6   LEU A C   1 ? 
ATOM   47   O O   . LEU A 1 6   ? -13.948 -24.585 14.540 1.00 24.37  ? 6   LEU A O   1 ? 
ATOM   48   C CB  . LEU A 1 6   ? -15.427 -22.339 12.885 1.00 23.52  ? 6   LEU A CB  1 ? 
ATOM   49   C CG  . LEU A 1 6   ? -15.449 -21.202 11.883 1.00 23.35  ? 6   LEU A CG  1 ? 
ATOM   50   C CD1 . LEU A 1 6   ? -16.565 -21.442 10.898 1.00 24.32  ? 6   LEU A CD1 1 ? 
ATOM   51   C CD2 . LEU A 1 6   ? -15.614 -19.876 12.576 1.00 35.28  ? 6   LEU A CD2 1 ? 
ATOM   52   N N   . GLY A 1 7   ? -15.468 -23.486 15.736 1.00 26.74  ? 7   GLY A N   1 ? 
ATOM   53   C CA  . GLY A 1 7   ? -15.836 -24.566 16.654 1.00 23.53  ? 7   GLY A CA  1 ? 
ATOM   54   C C   . GLY A 1 7   ? -16.162 -24.069 18.038 1.00 21.00  ? 7   GLY A C   1 ? 
ATOM   55   O O   . GLY A 1 7   ? -15.862 -22.966 18.377 1.00 24.46  ? 7   GLY A O   1 ? 
ATOM   56   N N   . ALA A 1 8   ? -16.662 -24.942 18.858 1.00 25.09  ? 8   ALA A N   1 ? 
ATOM   57   C CA  . ALA A 1 8   ? -16.992 -24.645 20.229 1.00 22.23  ? 8   ALA A CA  1 ? 
ATOM   58   C C   . ALA A 1 8   ? -15.717 -24.428 21.024 1.00 26.19  ? 8   ALA A C   1 ? 
ATOM   59   O O   . ALA A 1 8   ? -14.663 -24.990 20.701 1.00 28.52  ? 8   ALA A O   1 ? 
ATOM   60   C CB  . ALA A 1 8   ? -17.800 -25.781 20.851 1.00 29.24  ? 8   ALA A CB  1 ? 
ATOM   61   N N   . PRO A 1 9   ? -15.780 -23.596 22.046 1.00 28.32  ? 9   PRO A N   1 ? 
ATOM   62   C CA  . PRO A 1 9   ? -14.704 -23.552 23.032 1.00 27.35  ? 9   PRO A CA  1 ? 
ATOM   63   C C   . PRO A 1 9   ? -14.342 -24.946 23.515 1.00 26.37  ? 9   PRO A C   1 ? 
ATOM   64   O O   . PRO A 1 9   ? -15.205 -25.778 23.762 1.00 31.96  ? 9   PRO A O   1 ? 
ATOM   65   C CB  . PRO A 1 9   ? -15.298 -22.700 24.158 1.00 52.22  ? 9   PRO A CB  1 ? 
ATOM   66   C CG  . PRO A 1 9   ? -16.810 -22.723 23.899 1.00 44.41  ? 9   PRO A CG  1 ? 
ATOM   67   C CD  . PRO A 1 9   ? -16.937 -22.788 22.445 1.00 42.59  ? 9   PRO A CD  1 ? 
ATOM   68   N N   . GLY A 1 10  ? -13.036 -25.183 23.643 1.00 32.12  ? 10  GLY A N   1 ? 
ATOM   69   C CA  . GLY A 1 10  ? -12.480 -26.467 24.023 1.00 29.08  ? 10  GLY A CA  1 ? 
ATOM   70   C C   . GLY A 1 10  ? -12.490 -27.511 22.933 1.00 29.26  ? 10  GLY A C   1 ? 
ATOM   71   O O   . GLY A 1 10  ? -12.269 -28.679 23.228 1.00 27.67  ? 10  GLY A O   1 ? 
ATOM   72   N N   . ALA A 1 11  ? -12.763 -27.131 21.687 1.00 20.26  ? 11  ALA A N   1 ? 
ATOM   73   C CA  . ALA A 1 11  ? -12.830 -28.093 20.605 1.00 21.17  ? 11  ALA A CA  1 ? 
ATOM   74   C C   . ALA A 1 11  ? -11.458 -28.517 20.113 1.00 25.11  ? 11  ALA A C   1 ? 
ATOM   75   O O   . ALA A 1 11  ? -11.353 -29.439 19.283 1.00 25.27  ? 11  ALA A O   1 ? 
ATOM   76   C CB  . ALA A 1 11  ? -13.621 -27.532 19.417 1.00 21.41  ? 11  ALA A CB  1 ? 
ATOM   77   N N   . GLY A 1 12  ? -10.420 -27.861 20.591 1.00 23.48  ? 12  GLY A N   1 ? 
ATOM   78   C CA  . GLY A 1 12  ? -9.072  -28.180 20.208 1.00 26.30  ? 12  GLY A CA  1 ? 
ATOM   79   C C   . GLY A 1 12  ? -8.446  -27.208 19.245 1.00 25.36  ? 12  GLY A C   1 ? 
ATOM   80   O O   . GLY A 1 12  ? -7.442  -27.541 18.614 1.00 22.09  ? 12  GLY A O   1 ? 
ATOM   81   N N   . LYS A 1 13  ? -8.998  -26.015 19.113 1.00 22.02  ? 13  LYS A N   1 ? 
ATOM   82   C CA  . LYS A 1 13  ? -8.540  -25.106 18.060 1.00 28.35  ? 13  LYS A CA  1 ? 
ATOM   83   C C   . LYS A 1 13  ? -7.166  -24.526 18.377 1.00 25.57  ? 13  LYS A C   1 ? 
ATOM   84   O O   . LYS A 1 13  ? -6.305  -24.428 17.496 1.00 26.53  ? 13  LYS A O   1 ? 
ATOM   85   C CB  . LYS A 1 13  ? -9.530  -23.951 17.866 1.00 28.85  ? 13  LYS A CB  1 ? 
ATOM   86   C CG  . LYS A 1 13  ? -10.987 -24.261 17.528 1.00 23.95  ? 13  LYS A CG  1 ? 
ATOM   87   C CD  . LYS A 1 13  ? -11.704 -22.914 17.295 1.00 30.28  ? 13  LYS A CD  1 ? 
ATOM   88   C CE  . LYS A 1 13  ? -12.717 -22.549 18.389 1.00 39.52  ? 13  LYS A CE  1 ? 
ATOM   89   N NZ  . LYS A 1 13  ? -12.304 -22.838 19.778 1.00 38.89  ? 13  LYS A NZ  1 ? 
ATOM   90   N N   . GLY A 1 14  ? -6.967  -24.066 19.616 1.00 25.62  ? 14  GLY A N   1 ? 
ATOM   91   C CA  . GLY A 1 14  ? -5.674  -23.512 20.006 1.00 30.06  ? 14  GLY A CA  1 ? 
ATOM   92   C C   . GLY A 1 14  ? -4.571  -24.556 20.005 1.00 32.43  ? 14  GLY A C   1 ? 
ATOM   93   O O   . GLY A 1 14  ? -3.430  -24.257 19.638 1.00 26.80  ? 14  GLY A O   1 ? 
ATOM   94   N N   . THR A 1 15  ? -4.895  -25.788 20.417 1.00 23.35  ? 15  THR A N   1 ? 
ATOM   95   C CA  . THR A 1 15  ? -3.960  -26.901 20.276 1.00 22.90  ? 15  THR A CA  1 ? 
ATOM   96   C C   . THR A 1 15  ? -3.461  -27.032 18.841 1.00 24.04  ? 15  THR A C   1 ? 
ATOM   97   O O   . THR A 1 15  ? -2.249  -27.064 18.601 1.00 27.73  ? 15  THR A O   1 ? 
ATOM   98   C CB  . THR A 1 15  ? -4.640  -28.178 20.739 1.00 32.26  ? 15  THR A CB  1 ? 
ATOM   99   O OG1 . THR A 1 15  ? -5.103  -28.009 22.094 1.00 25.88  ? 15  THR A OG1 1 ? 
ATOM   100  C CG2 . THR A 1 15  ? -3.675  -29.321 20.711 1.00 35.45  ? 15  THR A CG2 1 ? 
ATOM   101  N N   . GLN A 1 16  ? -4.372  -27.045 17.861 1.00 20.80  ? 16  GLN A N   1 ? 
ATOM   102  C CA  . GLN A 1 16  ? -3.940  -27.250 16.478 1.00 19.05  ? 16  GLN A CA  1 ? 
ATOM   103  C C   . GLN A 1 16  ? -3.310  -26.032 15.823 1.00 25.62  ? 16  GLN A C   1 ? 
ATOM   104  O O   . GLN A 1 16  ? -2.572  -26.182 14.837 1.00 19.61  ? 16  GLN A O   1 ? 
ATOM   105  C CB  . GLN A 1 16  ? -5.115  -27.688 15.605 1.00 25.36  ? 16  GLN A CB  1 ? 
ATOM   106  C CG  . GLN A 1 16  ? -5.728  -29.004 16.021 1.00 26.12  ? 16  GLN A CG  1 ? 
ATOM   107  C CD  . GLN A 1 16  ? -4.766  -30.203 15.869 1.00 31.82  ? 16  GLN A CD  1 ? 
ATOM   108  O OE1 . GLN A 1 16  ? -3.899  -30.244 14.988 1.00 27.30  ? 16  GLN A OE1 1 ? 
ATOM   109  N NE2 . GLN A 1 16  ? -4.929  -31.174 16.745 1.00 26.56  ? 16  GLN A NE2 1 ? 
ATOM   110  N N   . ALA A 1 17  ? -3.615  -24.835 16.320 1.00 24.52  ? 17  ALA A N   1 ? 
ATOM   111  C CA  . ALA A 1 17  ? -3.053  -23.601 15.777 1.00 25.52  ? 17  ALA A CA  1 ? 
ATOM   112  C C   . ALA A 1 17  ? -1.528  -23.639 15.687 1.00 27.02  ? 17  ALA A C   1 ? 
ATOM   113  O O   . ALA A 1 17  ? -0.954  -23.204 14.677 1.00 21.77  ? 17  ALA A O   1 ? 
ATOM   114  C CB  . ALA A 1 17  ? -3.530  -22.420 16.628 1.00 28.11  ? 17  ALA A CB  1 ? 
ATOM   115  N N   . GLN A 1 18  ? -0.851  -24.155 16.720 1.00 28.65  ? 18  GLN A N   1 ? 
ATOM   116  C CA  . GLN A 1 18  ? 0.612   -24.149 16.701 1.00 30.54  ? 18  GLN A CA  1 ? 
ATOM   117  C C   . GLN A 1 18  ? 1.166   -24.869 15.481 1.00 25.18  ? 18  GLN A C   1 ? 
ATOM   118  O O   . GLN A 1 18  ? 2.073   -24.378 14.809 1.00 28.88  ? 18  GLN A O   1 ? 
ATOM   119  C CB  . GLN A 1 18  ? 1.150   -24.790 17.979 1.00 48.21  ? 18  GLN A CB  1 ? 
ATOM   120  C CG  . GLN A 1 18  ? 0.760   -24.012 19.246 1.00 52.10  ? 18  GLN A CG  1 ? 
ATOM   121  C CD  . GLN A 1 18  ? 1.736   -24.239 20.388 1.00 59.56  ? 18  GLN A CD  1 ? 
ATOM   122  O OE1 . GLN A 1 18  ? 2.022   -23.334 21.174 1.00 61.59  ? 18  GLN A OE1 1 ? 
ATOM   123  N NE2 . GLN A 1 18  ? 2.261   -25.454 20.475 1.00 38.63  ? 18  GLN A NE2 1 ? 
ATOM   124  N N   . PHE A 1 19  ? 0.634   -26.037 15.171 1.00 25.97  ? 19  PHE A N   1 ? 
ATOM   125  C CA  . PHE A 1 19  ? 1.107   -26.738 13.983 1.00 26.08  ? 19  PHE A CA  1 ? 
ATOM   126  C C   . PHE A 1 19  ? 0.887   -25.900 12.741 1.00 25.67  ? 19  PHE A C   1 ? 
ATOM   127  O O   . PHE A 1 19  ? 1.775   -25.806 11.886 1.00 21.60  ? 19  PHE A O   1 ? 
ATOM   128  C CB  . PHE A 1 19  ? 0.426   -28.099 13.891 1.00 32.59  ? 19  PHE A CB  1 ? 
ATOM   129  C CG  . PHE A 1 19  ? 0.448   -28.842 15.203 1.00 46.55  ? 19  PHE A CG  1 ? 
ATOM   130  C CD1 . PHE A 1 19  ? 1.647   -29.054 15.878 1.00 47.55  ? 19  PHE A CD1 1 ? 
ATOM   131  C CD2 . PHE A 1 19  ? -0.728  -29.341 15.756 1.00 49.68  ? 19  PHE A CD2 1 ? 
ATOM   132  C CE1 . PHE A 1 19  ? 1.676   -29.731 17.083 1.00 46.58  ? 19  PHE A CE1 1 ? 
ATOM   133  C CE2 . PHE A 1 19  ? -0.716  -30.033 16.942 1.00 41.02  ? 19  PHE A CE2 1 ? 
ATOM   134  C CZ  . PHE A 1 19  ? 0.483   -30.226 17.617 1.00 53.48  ? 19  PHE A CZ  1 ? 
ATOM   135  N N   . ILE A 1 20  ? -0.267  -25.240 12.641 1.00 22.48  ? 20  ILE A N   1 ? 
ATOM   136  C CA  . ILE A 1 20  ? -0.557  -24.492 11.425 1.00 18.21  ? 20  ILE A CA  1 ? 
ATOM   137  C C   . ILE A 1 20  ? 0.344   -23.262 11.321 1.00 21.44  ? 20  ILE A C   1 ? 
ATOM   138  O O   . ILE A 1 20  ? 0.908   -22.982 10.260 1.00 25.11  ? 20  ILE A O   1 ? 
ATOM   139  C CB  . ILE A 1 20  ? -2.030  -24.101 11.387 1.00 23.39  ? 20  ILE A CB  1 ? 
ATOM   140  C CG1 . ILE A 1 20  ? -2.890  -25.347 11.121 1.00 30.34  ? 20  ILE A CG1 1 ? 
ATOM   141  C CG2 . ILE A 1 20  ? -2.255  -23.075 10.305 1.00 21.41  ? 20  ILE A CG2 1 ? 
ATOM   142  C CD1 . ILE A 1 20  ? -4.265  -25.082 11.451 1.00 26.15  ? 20  ILE A CD1 1 ? 
ATOM   143  N N   . MET A 1 21  ? 0.531   -22.540 12.428 1.00 24.87  ? 21  MET A N   1 ? 
ATOM   144  C CA  . MET A 1 21  ? 1.434   -21.394 12.421 1.00 25.34  ? 21  MET A CA  1 ? 
ATOM   145  C C   . MET A 1 21  ? 2.835   -21.798 11.982 1.00 30.08  ? 21  MET A C   1 ? 
ATOM   146  O O   . MET A 1 21  ? 3.473   -21.129 11.159 1.00 26.77  ? 21  MET A O   1 ? 
ATOM   147  C CB  . MET A 1 21  ? 1.507   -20.802 13.814 1.00 20.87  ? 21  MET A CB  1 ? 
ATOM   148  C CG  . MET A 1 21  ? 0.160   -20.331 14.334 1.00 29.86  ? 21  MET A CG  1 ? 
ATOM   149  S SD  . MET A 1 21  ? 0.171   -20.377 16.149 1.00 36.51  ? 21  MET A SD  1 ? 
ATOM   150  C CE  . MET A 1 21  ? 1.455   -19.178 16.456 1.00 26.86  ? 21  MET A CE  1 ? 
ATOM   151  N N   . GLU A 1 22  ? 3.356   -22.864 12.580 1.00 27.75  ? 22  GLU A N   1 ? 
ATOM   152  C CA  . GLU A 1 22  ? 4.687   -23.322 12.227 1.00 28.79  ? 22  GLU A CA  1 ? 
ATOM   153  C C   . GLU A 1 22  ? 4.745   -23.696 10.756 1.00 29.12  ? 22  GLU A C   1 ? 
ATOM   154  O O   . GLU A 1 22  ? 5.712   -23.372 10.077 1.00 30.89  ? 22  GLU A O   1 ? 
ATOM   155  C CB  . GLU A 1 22  ? 5.071   -24.491 13.132 1.00 28.53  ? 22  GLU A CB  1 ? 
ATOM   156  C CG  . GLU A 1 22  ? 6.228   -25.315 12.631 1.00 37.95  ? 22  GLU A CG  1 ? 
ATOM   157  C CD  . GLU A 1 22  ? 6.630   -26.389 13.612 1.00 43.80  ? 22  GLU A CD  1 ? 
ATOM   158  O OE1 . GLU A 1 22  ? 6.695   -26.158 14.836 1.00 36.74  ? 22  GLU A OE1 1 ? 
ATOM   159  O OE2 . GLU A 1 22  ? 6.856   -27.510 13.170 1.00 52.63  ? 22  GLU A OE2 1 ? 
ATOM   160  N N   . LYS A 1 23  ? 3.763   -24.370 10.193 1.00 29.37  ? 23  LYS A N   1 ? 
ATOM   161  C CA  . LYS A 1 23  ? 3.935   -24.834 8.797  1.00 31.52  ? 23  LYS A CA  1 ? 
ATOM   162  C C   . LYS A 1 23  ? 3.805   -23.701 7.771  1.00 33.23  ? 23  LYS A C   1 ? 
ATOM   163  O O   . LYS A 1 23  ? 4.553   -23.741 6.835  1.00 40.23  ? 23  LYS A O   1 ? 
ATOM   164  C CB  . LYS A 1 23  ? 3.024   -26.017 8.490  1.00 44.85  ? 23  LYS A CB  1 ? 
ATOM   165  C CG  . LYS A 1 23  ? 3.333   -26.728 7.181  1.00 65.89  ? 23  LYS A CG  1 ? 
ATOM   166  C CD  . LYS A 1 23  ? 3.085   -28.217 7.221  1.00 73.85  ? 23  LYS A CD  1 ? 
ATOM   167  C CE  . LYS A 1 23  ? 3.540   -28.936 5.967  1.00 65.01  ? 23  LYS A CE  1 ? 
ATOM   168  N NZ  . LYS A 1 23  ? 2.618   -30.034 5.605  1.00 58.13  ? 23  LYS A NZ  1 ? 
ATOM   169  N N   . TYR A 1 24  ? 2.943   -22.712 7.960  1.00 29.32  ? 24  TYR A N   1 ? 
ATOM   170  C CA  . TYR A 1 24  ? 2.674   -21.647 6.996  1.00 28.19  ? 24  TYR A CA  1 ? 
ATOM   171  C C   . TYR A 1 24  ? 3.354   -20.336 7.377  1.00 27.52  ? 24  TYR A C   1 ? 
ATOM   172  O O   . TYR A 1 24  ? 3.271   -19.359 6.633  1.00 29.49  ? 24  TYR A O   1 ? 
ATOM   173  C CB  . TYR A 1 24  ? 1.138   -21.503 6.832  1.00 35.15  ? 24  TYR A CB  1 ? 
ATOM   174  C CG  . TYR A 1 24  ? 0.564   -22.774 6.195  1.00 48.73  ? 24  TYR A CG  1 ? 
ATOM   175  C CD1 . TYR A 1 24  ? 0.374   -23.950 6.940  1.00 51.66  ? 24  TYR A CD1 1 ? 
ATOM   176  C CD2 . TYR A 1 24  ? 0.280   -22.823 4.838  1.00 53.74  ? 24  TYR A CD2 1 ? 
ATOM   177  C CE1 . TYR A 1 24  ? -0.101  -25.132 6.338  1.00 44.81  ? 24  TYR A CE1 1 ? 
ATOM   178  C CE2 . TYR A 1 24  ? -0.199  -23.992 4.232  1.00 62.42  ? 24  TYR A CE2 1 ? 
ATOM   179  C CZ  . TYR A 1 24  ? -0.381  -25.141 4.984  1.00 62.00  ? 24  TYR A CZ  1 ? 
ATOM   180  O OH  . TYR A 1 24  ? -0.848  -26.288 4.375  1.00 75.34  ? 24  TYR A OH  1 ? 
ATOM   181  N N   . GLY A 1 25  ? 4.078   -20.313 8.488  1.00 22.12  ? 25  GLY A N   1 ? 
ATOM   182  C CA  . GLY A 1 25  ? 4.868   -19.157 8.843  1.00 22.77  ? 25  GLY A CA  1 ? 
ATOM   183  C C   . GLY A 1 25  ? 4.005   -17.962 9.125  1.00 27.05  ? 25  GLY A C   1 ? 
ATOM   184  O O   . GLY A 1 25  ? 4.288   -16.844 8.671  1.00 21.70  ? 25  GLY A O   1 ? 
ATOM   185  N N   . ILE A 1 26  ? 2.939   -18.179 9.882  1.00 22.67  ? 26  ILE A N   1 ? 
ATOM   186  C CA  . ILE A 1 26  ? 2.062   -17.060 10.188 1.00 18.27  ? 26  ILE A CA  1 ? 
ATOM   187  C C   . ILE A 1 26  ? 1.831   -16.966 11.688 1.00 24.17  ? 26  ILE A C   1 ? 
ATOM   188  O O   . ILE A 1 26  ? 1.924   -17.986 12.398 1.00 22.69  ? 26  ILE A O   1 ? 
ATOM   189  C CB  . ILE A 1 26  ? 0.725   -17.197 9.436  1.00 21.04  ? 26  ILE A CB  1 ? 
ATOM   190  C CG1 . ILE A 1 26  ? 0.102   -18.574 9.703  1.00 19.73  ? 26  ILE A CG1 1 ? 
ATOM   191  C CG2 . ILE A 1 26  ? 0.894   -17.057 7.913  1.00 22.00  ? 26  ILE A CG2 1 ? 
ATOM   192  C CD1 . ILE A 1 26  ? -1.123  -18.839 8.843  1.00 24.00  ? 26  ILE A CD1 1 ? 
ATOM   193  N N   . PRO A 1 27  ? 1.567   -15.768 12.209 1.00 23.06  ? 27  PRO A N   1 ? 
ATOM   194  C CA  . PRO A 1 27  ? 1.189   -15.625 13.615 1.00 21.07  ? 27  PRO A CA  1 ? 
ATOM   195  C C   . PRO A 1 27  ? -0.278  -15.952 13.818 1.00 30.76  ? 27  PRO A C   1 ? 
ATOM   196  O O   . PRO A 1 27  ? -1.088  -15.931 12.889 1.00 26.03  ? 27  PRO A O   1 ? 
ATOM   197  C CB  . PRO A 1 27  ? 1.463   -14.150 13.902 1.00 28.86  ? 27  PRO A CB  1 ? 
ATOM   198  C CG  . PRO A 1 27  ? 1.182   -13.461 12.569 1.00 31.91  ? 27  PRO A CG  1 ? 
ATOM   199  C CD  . PRO A 1 27  ? 1.558   -14.476 11.497 1.00 30.69  ? 27  PRO A CD  1 ? 
ATOM   200  N N   . GLN A 1 28  ? -0.598  -16.218 15.072 1.00 24.74  ? 28  GLN A N   1 ? 
ATOM   201  C CA  . GLN A 1 28  ? -1.944  -16.579 15.502 1.00 29.51  ? 28  GLN A CA  1 ? 
ATOM   202  C C   . GLN A 1 28  ? -2.559  -15.323 16.115 1.00 28.83  ? 28  GLN A C   1 ? 
ATOM   203  O O   . GLN A 1 28  ? -1.841  -14.642 16.840 1.00 29.85  ? 28  GLN A O   1 ? 
ATOM   204  C CB  . GLN A 1 28  ? -1.863  -17.693 16.536 1.00 39.09  ? 28  GLN A CB  1 ? 
ATOM   205  C CG  . GLN A 1 28  ? -3.030  -17.674 17.489 1.00 42.20  ? 28  GLN A CG  1 ? 
ATOM   206  C CD  . GLN A 1 28  ? -3.017  -18.874 18.387 1.00 37.46  ? 28  GLN A CD  1 ? 
ATOM   207  O OE1 . GLN A 1 28  ? -2.049  -19.167 19.059 1.00 51.47  ? 28  GLN A OE1 1 ? 
ATOM   208  N NE2 . GLN A 1 28  ? -4.120  -19.572 18.403 1.00 35.29  ? 28  GLN A NE2 1 ? 
ATOM   209  N N   . ILE A 1 29  ? -3.778  -14.966 15.744 1.00 24.40  ? 29  ILE A N   1 ? 
ATOM   210  C CA  . ILE A 1 29  ? -4.539  -13.855 16.331 1.00 28.35  ? 29  ILE A CA  1 ? 
ATOM   211  C C   . ILE A 1 29  ? -5.618  -14.489 17.199 1.00 29.32  ? 29  ILE A C   1 ? 
ATOM   212  O O   . ILE A 1 29  ? -6.644  -14.946 16.691 1.00 29.56  ? 29  ILE A O   1 ? 
ATOM   213  C CB  . ILE A 1 29  ? -5.166  -12.940 15.274 1.00 27.53  ? 29  ILE A CB  1 ? 
ATOM   214  C CG1 . ILE A 1 29  ? -4.151  -12.489 14.208 1.00 29.47  ? 29  ILE A CG1 1 ? 
ATOM   215  C CG2 . ILE A 1 29  ? -5.826  -11.745 15.917 1.00 28.24  ? 29  ILE A CG2 1 ? 
ATOM   216  C CD1 . ILE A 1 29  ? -2.834  -12.009 14.756 1.00 41.58  ? 29  ILE A CD1 1 ? 
ATOM   217  N N   . SER A 1 30  ? -5.392  -14.554 18.506 1.00 23.62  ? 30  SER A N   1 ? 
ATOM   218  C CA  . SER A 1 30  ? -6.314  -15.190 19.427 1.00 32.18  ? 30  SER A CA  1 ? 
ATOM   219  C C   . SER A 1 30  ? -6.927  -14.074 20.256 1.00 30.30  ? 30  SER A C   1 ? 
ATOM   220  O O   . SER A 1 30  ? -6.254  -13.489 21.106 1.00 25.21  ? 30  SER A O   1 ? 
ATOM   221  C CB  . SER A 1 30  ? -5.615  -16.220 20.310 1.00 26.69  ? 30  SER A CB  1 ? 
ATOM   222  O OG  . SER A 1 30  ? -6.395  -16.467 21.476 1.00 31.30  ? 30  SER A OG  1 ? 
ATOM   223  N N   . THR A 1 31  ? -8.191  -13.770 19.986 1.00 19.95  ? 31  THR A N   1 ? 
ATOM   224  C CA  . THR A 1 31  ? -8.873  -12.727 20.740 1.00 26.59  ? 31  THR A CA  1 ? 
ATOM   225  C C   . THR A 1 31  ? -8.893  -13.054 22.219 1.00 27.52  ? 31  THR A C   1 ? 
ATOM   226  O O   . THR A 1 31  ? -8.762  -12.148 23.062 1.00 31.52  ? 31  THR A O   1 ? 
ATOM   227  C CB  . THR A 1 31  ? -10.291 -12.522 20.185 1.00 23.89  ? 31  THR A CB  1 ? 
ATOM   228  O OG1 . THR A 1 31  ? -10.872 -13.772 19.799 1.00 26.65  ? 31  THR A OG1 1 ? 
ATOM   229  C CG2 . THR A 1 31  ? -10.184 -11.622 18.969 1.00 22.86  ? 31  THR A CG2 1 ? 
ATOM   230  N N   . GLY A 1 32  ? -9.011  -14.332 22.562 1.00 25.51  ? 32  GLY A N   1 ? 
ATOM   231  C CA  . GLY A 1 32  ? -8.980  -14.695 23.967 1.00 28.90  ? 32  GLY A CA  1 ? 
ATOM   232  C C   . GLY A 1 32  ? -7.662  -14.291 24.600 1.00 30.48  ? 32  GLY A C   1 ? 
ATOM   233  O O   . GLY A 1 32  ? -7.634  -13.689 25.667 1.00 23.64  ? 32  GLY A O   1 ? 
ATOM   234  N N   . ASP A 1 33  ? -6.552  -14.589 23.918 1.00 25.81  ? 33  ASP A N   1 ? 
ATOM   235  C CA  . ASP A 1 33  ? -5.225  -14.242 24.403 1.00 28.71  ? 33  ASP A CA  1 ? 
ATOM   236  C C   . ASP A 1 33  ? -5.043  -12.731 24.472 1.00 31.12  ? 33  ASP A C   1 ? 
ATOM   237  O O   . ASP A 1 33  ? -4.512  -12.209 25.454 1.00 23.25  ? 33  ASP A O   1 ? 
ATOM   238  C CB  . ASP A 1 33  ? -4.145  -14.864 23.492 1.00 34.81  ? 33  ASP A CB  1 ? 
ATOM   239  C CG  . ASP A 1 33  ? -4.008  -16.437 23.608 1.00 47.87  ? 33  ASP A CG  1 ? 
ATOM   240  O OD1 . ASP A 1 33  ? -4.580  -17.084 24.502 1.00 45.09  ? 33  ASP A OD1 1 ? 
ATOM   241  O OD2 . ASP A 1 33  ? -3.280  -17.024 22.760 1.00 45.45  ? 33  ASP A OD2 1 ? 
ATOM   242  N N   . MET A 1 34  ? -5.473  -12.011 23.428 1.00 22.94  ? 34  MET A N   1 ? 
ATOM   243  C CA  . MET A 1 34  ? -5.269  -10.568 23.394 1.00 25.23  ? 34  MET A CA  1 ? 
ATOM   244  C C   . MET A 1 34  ? -6.048  -9.883  24.523 1.00 27.19  ? 34  MET A C   1 ? 
ATOM   245  O O   . MET A 1 34  ? -5.565  -8.918  25.119 1.00 27.36  ? 34  MET A O   1 ? 
ATOM   246  C CB  . MET A 1 34  ? -5.720  -10.079 22.030 1.00 26.01  ? 34  MET A CB  1 ? 
ATOM   247  C CG  . MET A 1 34  ? -4.804  -10.548 20.916 1.00 31.05  ? 34  MET A CG  1 ? 
ATOM   248  S SD  . MET A 1 34  ? -5.131  -9.357  19.592 1.00 47.07  ? 34  MET A SD  1 ? 
ATOM   249  C CE  . MET A 1 34  ? -6.606  -10.138 18.854 1.00 36.55  ? 34  MET A CE  1 ? 
ATOM   250  N N   . LEU A 1 35  ? -7.249  -10.390 24.837 1.00 25.19  ? 35  LEU A N   1 ? 
ATOM   251  C CA  . LEU A 1 35  ? -8.060  -9.810  25.906 1.00 20.67  ? 35  LEU A CA  1 ? 
ATOM   252  C C   . LEU A 1 35  ? -7.456  -10.132 27.265 1.00 25.64  ? 35  LEU A C   1 ? 
ATOM   253  O O   . LEU A 1 35  ? -7.415  -9.279  28.141 1.00 25.72  ? 35  LEU A O   1 ? 
ATOM   254  C CB  . LEU A 1 35  ? -9.494  -10.322 25.835 1.00 22.92  ? 35  LEU A CB  1 ? 
ATOM   255  C CG  . LEU A 1 35  ? -10.362 -9.801  24.684 1.00 25.11  ? 35  LEU A CG  1 ? 
ATOM   256  C CD1 . LEU A 1 35  ? -11.573 -10.744 24.482 1.00 24.79  ? 35  LEU A CD1 1 ? 
ATOM   257  C CD2 . LEU A 1 35  ? -10.810 -8.348  24.895 1.00 27.20  ? 35  LEU A CD2 1 ? 
ATOM   258  N N   . ARG A 1 36  ? -6.997  -11.362 27.476 1.00 30.95  ? 36  ARG A N   1 ? 
ATOM   259  C CA  . ARG A 1 36  ? -6.386  -11.676 28.769 1.00 30.65  ? 36  ARG A CA  1 ? 
ATOM   260  C C   . ARG A 1 36  ? -5.104  -10.879 28.946 1.00 32.89  ? 36  ARG A C   1 ? 
ATOM   261  O O   . ARG A 1 36  ? -4.835  -10.379 30.039 1.00 27.01  ? 36  ARG A O   1 ? 
ATOM   262  C CB  . ARG A 1 36  ? -6.149  -13.174 28.912 1.00 31.37  ? 36  ARG A CB  1 ? 
ATOM   263  C CG  . ARG A 1 36  ? -7.431  -13.971 29.099 1.00 29.17  ? 36  ARG A CG  1 ? 
ATOM   264  C CD  . ARG A 1 36  ? -7.141  -15.442 29.290 1.00 40.40  ? 36  ARG A CD  1 ? 
ATOM   265  N NE  . ARG A 1 36  ? -6.668  -16.130 28.081 1.00 39.90  ? 36  ARG A NE  1 ? 
ATOM   266  C CZ  . ARG A 1 36  ? -7.454  -16.746 27.188 1.00 37.30  ? 36  ARG A CZ  1 ? 
ATOM   267  N NH1 . ARG A 1 36  ? -8.769  -16.750 27.335 1.00 29.77  ? 36  ARG A NH1 1 ? 
ATOM   268  N NH2 . ARG A 1 36  ? -6.919  -17.365 26.138 1.00 33.33  ? 36  ARG A NH2 1 ? 
ATOM   269  N N   . ALA A 1 37  ? -4.339  -10.683 27.865 1.00 30.04  ? 37  ALA A N   1 ? 
ATOM   270  C CA  . ALA A 1 37  ? -3.174  -9.817  27.953 1.00 31.03  ? 37  ALA A CA  1 ? 
ATOM   271  C C   . ALA A 1 37  ? -3.565  -8.372  28.243 1.00 36.84  ? 37  ALA A C   1 ? 
ATOM   272  O O   . ALA A 1 37  ? -2.820  -7.655  28.925 1.00 31.68  ? 37  ALA A O   1 ? 
ATOM   273  C CB  . ALA A 1 37  ? -2.347  -9.849  26.666 1.00 34.48  ? 37  ALA A CB  1 ? 
ATOM   274  N N   . ALA A 1 38  ? -4.691  -7.900  27.684 1.00 29.62  ? 38  ALA A N   1 ? 
ATOM   275  C CA  . ALA A 1 38  ? -5.096  -6.516  27.912 1.00 32.30  ? 38  ALA A CA  1 ? 
ATOM   276  C C   . ALA A 1 38  ? -5.396  -6.298  29.387 1.00 35.30  ? 38  ALA A C   1 ? 
ATOM   277  O O   . ALA A 1 38  ? -4.967  -5.315  29.989 1.00 38.67  ? 38  ALA A O   1 ? 
ATOM   278  C CB  . ALA A 1 38  ? -6.326  -6.161  27.068 1.00 31.82  ? 38  ALA A CB  1 ? 
ATOM   279  N N   . VAL A 1 39  ? -6.103  -7.240  29.984 1.00 31.77  ? 39  VAL A N   1 ? 
ATOM   280  C CA  . VAL A 1 39  ? -6.406  -7.198  31.406 1.00 31.24  ? 39  VAL A CA  1 ? 
ATOM   281  C C   . VAL A 1 39  ? -5.134  -7.140  32.231 1.00 35.80  ? 39  VAL A C   1 ? 
ATOM   282  O O   . VAL A 1 39  ? -4.992  -6.313  33.135 1.00 39.09  ? 39  VAL A O   1 ? 
ATOM   283  C CB  . VAL A 1 39  ? -7.242  -8.429  31.764 1.00 30.94  ? 39  VAL A CB  1 ? 
ATOM   284  C CG1 . VAL A 1 39  ? -7.526  -8.464  33.253 1.00 38.82  ? 39  VAL A CG1 1 ? 
ATOM   285  C CG2 . VAL A 1 39  ? -8.498  -8.412  30.880 1.00 36.35  ? 39  VAL A CG2 1 ? 
ATOM   286  N N   . LYS A 1 40  ? -4.226  -8.075  31.984 1.00 42.15  ? 40  LYS A N   1 ? 
ATOM   287  C CA  . LYS A 1 40  ? -3.005  -8.147  32.770 1.00 41.86  ? 40  LYS A CA  1 ? 
ATOM   288  C C   . LYS A 1 40  ? -2.216  -6.849  32.681 1.00 46.41  ? 40  LYS A C   1 ? 
ATOM   289  O O   . LYS A 1 40  ? -1.699  -6.349  33.681 1.00 50.83  ? 40  LYS A O   1 ? 
ATOM   290  C CB  . LYS A 1 40  ? -2.144  -9.315  32.281 1.00 41.78  ? 40  LYS A CB  1 ? 
ATOM   291  C CG  . LYS A 1 40  ? -1.308  -9.978  33.382 1.00 48.34  ? 40  LYS A CG  1 ? 
ATOM   292  C CD  . LYS A 1 40  ? -0.313  -10.986 32.816 1.00 46.33  ? 40  LYS A CD  1 ? 
ATOM   293  C CE  . LYS A 1 40  ? 0.457   -11.701 33.933 1.00 72.80  ? 40  LYS A CE  1 ? 
ATOM   294  N NZ  . LYS A 1 40  ? -0.437  -12.196 35.050 1.00 72.52  ? 40  LYS A NZ  1 ? 
ATOM   295  N N   . SER A 1 41  ? -2.069  -6.308  31.484 1.00 37.78  ? 41  SER A N   1 ? 
ATOM   296  C CA  . SER A 1 41  ? -1.185  -5.168  31.346 1.00 40.77  ? 41  SER A CA  1 ? 
ATOM   297  C C   . SER A 1 41  ? -1.862  -3.845  31.650 1.00 36.59  ? 41  SER A C   1 ? 
ATOM   298  O O   . SER A 1 41  ? -1.190  -2.804  31.620 1.00 41.33  ? 41  SER A O   1 ? 
ATOM   299  C CB  . SER A 1 41  ? -0.630  -5.137  29.930 1.00 43.43  ? 41  SER A CB  1 ? 
ATOM   300  O OG  . SER A 1 41  ? -1.582  -4.529  29.089 1.00 46.58  ? 41  SER A OG  1 ? 
ATOM   301  N N   . GLY A 1 42  ? -3.164  -3.872  31.929 1.00 44.58  ? 42  GLY A N   1 ? 
ATOM   302  C CA  . GLY A 1 42  ? -3.978  -2.672  32.063 1.00 37.85  ? 42  GLY A CA  1 ? 
ATOM   303  C C   . GLY A 1 42  ? -4.120  -1.851  30.807 1.00 32.35  ? 42  GLY A C   1 ? 
ATOM   304  O O   . GLY A 1 42  ? -4.216  -0.636  30.895 1.00 41.80  ? 42  GLY A O   1 ? 
ATOM   305  N N   . SER A 1 43  ? -4.137  -2.474  29.629 1.00 40.63  ? 43  SER A N   1 ? 
ATOM   306  C CA  . SER A 1 43  ? -4.272  -1.682  28.408 1.00 39.28  ? 43  SER A CA  1 ? 
ATOM   307  C C   . SER A 1 43  ? -5.677  -1.097  28.282 1.00 32.22  ? 43  SER A C   1 ? 
ATOM   308  O O   . SER A 1 43  ? -6.682  -1.742  28.611 1.00 42.62  ? 43  SER A O   1 ? 
ATOM   309  C CB  . SER A 1 43  ? -3.934  -2.490  27.155 1.00 40.02  ? 43  SER A CB  1 ? 
ATOM   310  O OG  . SER A 1 43  ? -2.531  -2.716  27.055 1.00 53.33  ? 43  SER A OG  1 ? 
ATOM   311  N N   . GLU A 1 44  ? -5.741  0.149   27.806 1.00 37.23  ? 44  GLU A N   1 ? 
ATOM   312  C CA  . GLU A 1 44  ? -7.027  0.830   27.744 1.00 35.81  ? 44  GLU A CA  1 ? 
ATOM   313  C C   . GLU A 1 44  ? -7.984  0.060   26.853 1.00 34.62  ? 44  GLU A C   1 ? 
ATOM   314  O O   . GLU A 1 44  ? -9.172  -0.052  27.172 1.00 32.40  ? 44  GLU A O   1 ? 
ATOM   315  C CB  . GLU A 1 44  ? -6.876  2.268   27.249 1.00 37.04  ? 44  GLU A CB  1 ? 
ATOM   316  C CG  . GLU A 1 44  ? -8.232  3.018   27.105 1.00 42.58  ? 44  GLU A CG  1 ? 
ATOM   317  C CD  . GLU A 1 44  ? -9.089  3.068   28.390 1.00 63.16  ? 44  GLU A CD  1 ? 
ATOM   318  O OE1 . GLU A 1 44  ? -8.544  3.022   29.520 1.00 58.17  ? 44  GLU A OE1 1 ? 
ATOM   319  O OE2 . GLU A 1 44  ? -10.331 3.192   28.249 1.00 52.35  ? 44  GLU A OE2 1 ? 
ATOM   320  N N   . LEU A 1 45  ? -7.477  -0.510  25.757 1.00 33.40  ? 45  LEU A N   1 ? 
ATOM   321  C CA  . LEU A 1 45  ? -8.285  -1.325  24.839 1.00 32.14  ? 45  LEU A CA  1 ? 
ATOM   322  C C   . LEU A 1 45  ? -8.279  -2.784  25.290 1.00 33.88  ? 45  LEU A C   1 ? 
ATOM   323  O O   . LEU A 1 45  ? -7.418  -3.584  24.902 1.00 29.51  ? 45  LEU A O   1 ? 
ATOM   324  C CB  . LEU A 1 45  ? -7.765  -1.198  23.419 1.00 34.32  ? 45  LEU A CB  1 ? 
ATOM   325  C CG  . LEU A 1 45  ? -8.675  -1.778  22.327 1.00 38.62  ? 45  LEU A CG  1 ? 
ATOM   326  C CD1 . LEU A 1 45  ? -9.975  -0.997  22.236 1.00 40.77  ? 45  LEU A CD1 1 ? 
ATOM   327  C CD2 . LEU A 1 45  ? -7.908  -1.798  21.023 1.00 35.54  ? 45  LEU A CD2 1 ? 
ATOM   328  N N   . GLY A 1 46  ? -9.290  -3.144  26.084 1.00 34.20  ? 46  GLY A N   1 ? 
ATOM   329  C CA  . GLY A 1 46  ? -9.504  -4.518  26.490 1.00 37.22  ? 46  GLY A CA  1 ? 
ATOM   330  C C   . GLY A 1 46  ? -9.535  -4.828  27.970 1.00 30.92  ? 46  GLY A C   1 ? 
ATOM   331  O O   . GLY A 1 46  ? -10.076 -5.871  28.356 1.00 31.89  ? 46  GLY A O   1 ? 
ATOM   332  N N   . LYS A 1 47  ? -8.953  -3.986  28.822 1.00 33.33  ? 47  LYS A N   1 ? 
ATOM   333  C CA  . LYS A 1 47  ? -9.064  -4.230  30.261 1.00 33.75  ? 47  LYS A CA  1 ? 
ATOM   334  C C   . LYS A 1 47  ? -10.517 -4.421  30.694 1.00 31.13  ? 47  LYS A C   1 ? 
ATOM   335  O O   . LYS A 1 47  ? -10.777 -5.072  31.708 1.00 38.42  ? 47  LYS A O   1 ? 
ATOM   336  C CB  . LYS A 1 47  ? -8.425  -3.063  31.018 1.00 44.85  ? 47  LYS A CB  1 ? 
ATOM   337  C CG  . LYS A 1 47  ? -9.227  -1.743  31.076 1.00 42.85  ? 47  LYS A CG  1 ? 
ATOM   338  C CD  . LYS A 1 47  ? -8.837  -0.943  32.325 1.00 55.20  ? 47  LYS A CD  1 ? 
ATOM   339  C CE  . LYS A 1 47  ? -8.828  0.567   32.090 1.00 65.99  ? 47  LYS A CE  1 ? 
ATOM   340  N NZ  . LYS A 1 47  ? -7.802  1.234   32.944 1.00 63.36  ? 47  LYS A NZ  1 ? 
ATOM   341  N N   . GLN A 1 48  ? -11.471 -3.843  29.944 1.00 31.88  ? 48  GLN A N   1 ? 
ATOM   342  C CA  . GLN A 1 48  ? -12.883 -3.869  30.288 1.00 33.86  ? 48  GLN A CA  1 ? 
ATOM   343  C C   . GLN A 1 48  ? -13.468 -5.259  30.227 1.00 28.96  ? 48  GLN A C   1 ? 
ATOM   344  O O   . GLN A 1 48  ? -14.544 -5.498  30.789 1.00 36.95  ? 48  GLN A O   1 ? 
ATOM   345  C CB  . GLN A 1 48  ? -13.667 -2.960  29.326 1.00 39.07  ? 48  GLN A CB  1 ? 
ATOM   346  C CG  . GLN A 1 48  ? -13.149 -1.529  29.294 1.00 26.76  ? 48  GLN A CG  1 ? 
ATOM   347  C CD  . GLN A 1 48  ? -12.089 -1.273  28.247 1.00 37.18  ? 48  GLN A CD  1 ? 
ATOM   348  O OE1 . GLN A 1 48  ? -11.600 -2.204  27.591 1.00 30.41  ? 48  GLN A OE1 1 ? 
ATOM   349  N NE2 . GLN A 1 48  ? -11.695 -0.011  28.106 1.00 38.46  ? 48  GLN A NE2 1 ? 
ATOM   350  N N   . ALA A 1 49  ? -12.764 -6.184  29.576 1.00 36.83  ? 49  ALA A N   1 ? 
ATOM   351  C CA  . ALA A 1 49  ? -13.263 -7.534  29.373 1.00 30.59  ? 49  ALA A CA  1 ? 
ATOM   352  C C   . ALA A 1 49  ? -13.277 -8.368  30.637 1.00 33.22  ? 49  ALA A C   1 ? 
ATOM   353  O O   . ALA A 1 49  ? -13.990 -9.370  30.680 1.00 26.78  ? 49  ALA A O   1 ? 
ATOM   354  C CB  . ALA A 1 49  ? -12.410 -8.299  28.349 1.00 30.71  ? 49  ALA A CB  1 ? 
ATOM   355  N N   . LYS A 1 50  ? -12.473 -8.015  31.638 1.00 31.51  ? 50  LYS A N   1 ? 
ATOM   356  C CA  . LYS A 1 50  ? -12.209 -8.945  32.733 1.00 35.61  ? 50  LYS A CA  1 ? 
ATOM   357  C C   . LYS A 1 50  ? -13.497 -9.583  33.248 1.00 41.22  ? 50  LYS A C   1 ? 
ATOM   358  O O   . LYS A 1 50  ? -13.610 -10.814 33.322 1.00 35.43  ? 50  LYS A O   1 ? 
ATOM   359  C CB  . LYS A 1 50  ? -11.467 -8.210  33.854 1.00 40.32  ? 50  LYS A CB  1 ? 
ATOM   360  C CG  . LYS A 1 50  ? -11.013 -9.090  34.994 1.00 51.49  ? 50  LYS A CG  1 ? 
ATOM   361  C CD  . LYS A 1 50  ? -12.145 -9.365  35.965 1.00 63.32  ? 50  LYS A CD  1 ? 
ATOM   362  C CE  . LYS A 1 50  ? -11.646 -9.578  37.393 1.00 67.56  ? 50  LYS A CE  1 ? 
ATOM   363  N NZ  . LYS A 1 50  ? -11.105 -10.956 37.641 1.00 68.66  ? 50  LYS A NZ  1 ? 
ATOM   364  N N   . ASP A 1 51  ? -14.496 -8.751  33.576 1.00 37.80  ? 51  ASP A N   1 ? 
ATOM   365  C CA  . ASP A 1 51  ? -15.697 -9.218  34.265 1.00 35.22  ? 51  ASP A CA  1 ? 
ATOM   366  C C   . ASP A 1 51  ? -16.593 -10.029 33.336 1.00 32.57  ? 51  ASP A C   1 ? 
ATOM   367  O O   . ASP A 1 51  ? -17.155 -11.050 33.737 1.00 32.22  ? 51  ASP A O   1 ? 
ATOM   368  C CB  . ASP A 1 51  ? -16.494 -8.026  34.831 1.00 51.55  ? 51  ASP A CB  1 ? 
ATOM   369  C CG  . ASP A 1 51  ? -15.794 -7.298  35.993 1.00 63.35  ? 51  ASP A CG  1 ? 
ATOM   370  O OD1 . ASP A 1 51  ? -14.844 -7.856  36.585 1.00 51.97  ? 51  ASP A OD1 1 ? 
ATOM   371  O OD2 . ASP A 1 51  ? -16.223 -6.167  36.335 1.00 72.30  ? 51  ASP A OD2 1 ? 
ATOM   372  N N   . ILE A 1 52  ? -16.752 -9.555  32.102 1.00 26.95  ? 52  ILE A N   1 ? 
ATOM   373  C CA  . ILE A 1 52  ? -17.472 -10.274 31.057 1.00 30.12  ? 52  ILE A CA  1 ? 
ATOM   374  C C   . ILE A 1 52  ? -16.916 -11.685 30.896 1.00 28.52  ? 52  ILE A C   1 ? 
ATOM   375  O O   . ILE A 1 52  ? -17.669 -12.667 30.866 1.00 30.81  ? 52  ILE A O   1 ? 
ATOM   376  C CB  . ILE A 1 52  ? -17.372 -9.473  29.743 1.00 25.80  ? 52  ILE A CB  1 ? 
ATOM   377  C CG1 . ILE A 1 52  ? -17.799 -7.999  29.963 1.00 36.00  ? 52  ILE A CG1 1 ? 
ATOM   378  C CG2 . ILE A 1 52  ? -18.207 -10.119 28.652 1.00 29.48  ? 52  ILE A CG2 1 ? 
ATOM   379  C CD1 . ILE A 1 52  ? -17.259 -7.024  28.893 1.00 41.22  ? 52  ILE A CD1 1 ? 
ATOM   380  N N   . MET A 1 53  ? -15.585 -11.810 30.809 1.00 29.95  ? 53  MET A N   1 ? 
ATOM   381  C CA  . MET A 1 53  ? -14.976 -13.116 30.569 1.00 28.81  ? 53  MET A CA  1 ? 
ATOM   382  C C   . MET A 1 53  ? -15.240 -14.062 31.732 1.00 37.40  ? 53  MET A C   1 ? 
ATOM   383  O O   . MET A 1 53  ? -15.673 -15.199 31.529 1.00 33.51  ? 53  MET A O   1 ? 
ATOM   384  C CB  . MET A 1 53  ? -13.474 -12.977 30.314 1.00 28.13  ? 53  MET A CB  1 ? 
ATOM   385  C CG  . MET A 1 53  ? -13.186 -12.513 28.905 1.00 25.96  ? 53  MET A CG  1 ? 
ATOM   386  S SD  . MET A 1 53  ? -11.491 -12.677 28.363 1.00 34.42  ? 53  MET A SD  1 ? 
ATOM   387  C CE  . MET A 1 53  ? -10.746 -11.358 29.294 1.00 29.84  ? 53  MET A CE  1 ? 
ATOM   388  N N   . ASP A 1 54  ? -15.007 -13.616 32.959 1.00 31.79  ? 54  ASP A N   1 ? 
ATOM   389  C CA  . ASP A 1 54  ? -15.288 -14.493 34.093 1.00 32.08  ? 54  ASP A CA  1 ? 
ATOM   390  C C   . ASP A 1 54  ? -16.744 -14.917 34.190 1.00 28.11  ? 54  ASP A C   1 ? 
ATOM   391  O O   . ASP A 1 54  ? -17.023 -15.941 34.818 1.00 47.14  ? 54  ASP A O   1 ? 
ATOM   392  C CB  . ASP A 1 54  ? -14.853 -13.803 35.369 1.00 33.56  ? 54  ASP A CB  1 ? 
ATOM   393  C CG  . ASP A 1 54  ? -13.390 -13.623 35.412 1.00 50.83  ? 54  ASP A CG  1 ? 
ATOM   394  O OD1 . ASP A 1 54  ? -12.925 -12.795 36.213 1.00 61.63  ? 54  ASP A OD1 1 ? 
ATOM   395  O OD2 . ASP A 1 54  ? -12.701 -14.313 34.620 1.00 59.68  ? 54  ASP A OD2 1 ? 
ATOM   396  N N   . ALA A 1 55  ? -17.665 -14.162 33.598 1.00 32.31  ? 55  ALA A N   1 ? 
ATOM   397  C CA  . ALA A 1 55  ? -19.082 -14.494 33.572 1.00 34.47  ? 55  ALA A CA  1 ? 
ATOM   398  C C   . ALA A 1 55  ? -19.422 -15.467 32.462 1.00 36.61  ? 55  ALA A C   1 ? 
ATOM   399  O O   . ALA A 1 55  ? -20.589 -15.878 32.339 1.00 30.84  ? 55  ALA A O   1 ? 
ATOM   400  C CB  . ALA A 1 55  ? -19.912 -13.226 33.382 1.00 39.59  ? 55  ALA A CB  1 ? 
ATOM   401  N N   . GLY A 1 56  ? -18.437 -15.837 31.651 1.00 28.83  ? 56  GLY A N   1 ? 
ATOM   402  C CA  . GLY A 1 56  ? -18.726 -16.631 30.480 1.00 39.56  ? 56  GLY A CA  1 ? 
ATOM   403  C C   . GLY A 1 56  ? -19.618 -15.946 29.485 1.00 31.50  ? 56  GLY A C   1 ? 
ATOM   404  O O   . GLY A 1 56  ? -20.394 -16.613 28.806 1.00 44.46  ? 56  GLY A O   1 ? 
ATOM   405  N N   . LYS A 1 57  ? -19.541 -14.637 29.363 1.00 32.09  ? 57  LYS A N   1 ? 
ATOM   406  C CA  . LYS A 1 57  ? -20.305 -13.980 28.321 1.00 34.94  ? 57  LYS A CA  1 ? 
ATOM   407  C C   . LYS A 1 57  ? -19.364 -13.575 27.209 1.00 23.71  ? 57  LYS A C   1 ? 
ATOM   408  O O   . LYS A 1 57  ? -18.148 -13.560 27.367 1.00 26.44  ? 57  LYS A O   1 ? 
ATOM   409  C CB  . LYS A 1 57  ? -21.030 -12.755 28.895 1.00 43.70  ? 57  LYS A CB  1 ? 
ATOM   410  C CG  . LYS A 1 57  ? -22.358 -13.017 29.589 1.00 43.61  ? 57  LYS A CG  1 ? 
ATOM   411  C CD  . LYS A 1 57  ? -22.896 -11.710 30.168 1.00 54.31  ? 57  LYS A CD  1 ? 
ATOM   412  C CE  . LYS A 1 57  ? -23.687 -11.927 31.463 1.00 67.35  ? 57  LYS A CE  1 ? 
ATOM   413  N NZ  . LYS A 1 57  ? -24.910 -12.703 31.120 1.00 77.78  ? 57  LYS A NZ  1 ? 
ATOM   414  N N   . LEU A 1 58  ? -19.928 -13.239 26.066 1.00 23.04  ? 58  LEU A N   1 ? 
ATOM   415  C CA  . LEU A 1 58  ? -19.109 -12.676 25.012 1.00 23.02  ? 58  LEU A CA  1 ? 
ATOM   416  C C   . LEU A 1 58  ? -18.807 -11.204 25.300 1.00 31.84  ? 58  LEU A C   1 ? 
ATOM   417  O O   . LEU A 1 58  ? -19.594 -10.496 25.931 1.00 30.32  ? 58  LEU A O   1 ? 
ATOM   418  C CB  . LEU A 1 58  ? -19.807 -12.812 23.668 1.00 23.24  ? 58  LEU A CB  1 ? 
ATOM   419  C CG  . LEU A 1 58  ? -19.816 -14.233 23.136 1.00 30.21  ? 58  LEU A CG  1 ? 
ATOM   420  C CD1 . LEU A 1 58  ? -20.337 -14.282 21.709 1.00 34.88  ? 58  LEU A CD1 1 ? 
ATOM   421  C CD2 . LEU A 1 58  ? -18.453 -14.896 23.182 1.00 32.85  ? 58  LEU A CD2 1 ? 
ATOM   422  N N   . VAL A 1 59  ? -17.653 -10.746 24.816 1.00 22.50  ? 59  VAL A N   1 ? 
ATOM   423  C CA  . VAL A 1 59  ? -17.296 -9.339  24.895 1.00 23.50  ? 59  VAL A CA  1 ? 
ATOM   424  C C   . VAL A 1 59  ? -17.976 -8.593  23.755 1.00 26.37  ? 59  VAL A C   1 ? 
ATOM   425  O O   . VAL A 1 59  ? -18.353 -9.181  22.751 1.00 21.98  ? 59  VAL A O   1 ? 
ATOM   426  C CB  . VAL A 1 59  ? -15.766 -9.175  24.857 1.00 31.61  ? 59  VAL A CB  1 ? 
ATOM   427  C CG1 . VAL A 1 59  ? -15.373 -7.728  24.684 1.00 30.70  ? 59  VAL A CG1 1 ? 
ATOM   428  C CG2 . VAL A 1 59  ? -15.187 -9.714  26.134 1.00 24.86  ? 59  VAL A CG2 1 ? 
ATOM   429  N N   . THR A 1 60  ? -18.164 -7.286  23.912 1.00 19.01  ? 60  THR A N   1 ? 
ATOM   430  C CA  . THR A 1 60  ? -18.893 -6.587  22.852 1.00 23.16  ? 60  THR A CA  1 ? 
ATOM   431  C C   . THR A 1 60  ? -18.160 -6.674  21.514 1.00 21.90  ? 60  THR A C   1 ? 
ATOM   432  O O   . THR A 1 60  ? -16.935 -6.617  21.456 1.00 23.11  ? 60  THR A O   1 ? 
ATOM   433  C CB  . THR A 1 60  ? -19.098 -5.115  23.156 1.00 28.38  ? 60  THR A CB  1 ? 
ATOM   434  O OG1 . THR A 1 60  ? -17.787 -4.517  23.210 1.00 35.11  ? 60  THR A OG1 1 ? 
ATOM   435  C CG2 . THR A 1 60  ? -19.888 -4.877  24.450 1.00 28.35  ? 60  THR A CG2 1 ? 
ATOM   436  N N   . ASP A 1 61  ? -18.934 -6.711  20.418 1.00 24.09  ? 61  ASP A N   1 ? 
ATOM   437  C CA  . ASP A 1 61  ? -18.373 -6.847  19.075 1.00 23.51  ? 61  ASP A CA  1 ? 
ATOM   438  C C   . ASP A 1 61  ? -17.427 -5.689  18.770 1.00 31.49  ? 61  ASP A C   1 ? 
ATOM   439  O O   . ASP A 1 61  ? -16.324 -5.882  18.230 1.00 25.24  ? 61  ASP A O   1 ? 
ATOM   440  C CB  . ASP A 1 61  ? -19.490 -6.879  18.005 1.00 28.11  ? 61  ASP A CB  1 ? 
ATOM   441  C CG  . ASP A 1 61  ? -20.404 -8.117  18.060 1.00 37.31  ? 61  ASP A CG  1 ? 
ATOM   442  O OD1 . ASP A 1 61  ? -19.953 -9.240  18.373 1.00 23.44  ? 61  ASP A OD1 1 ? 
ATOM   443  O OD2 . ASP A 1 61  ? -21.605 -7.977  17.696 1.00 35.12  ? 61  ASP A OD2 1 ? 
ATOM   444  N N   . GLU A 1 62  ? -17.861 -4.469  19.110 1.00 23.83  ? 62  GLU A N   1 ? 
ATOM   445  C CA  . GLU A 1 62  ? -17.066 -3.264  18.883 1.00 24.69  ? 62  GLU A CA  1 ? 
ATOM   446  C C   . GLU A 1 62  ? -15.674 -3.372  19.522 1.00 26.91  ? 62  GLU A C   1 ? 
ATOM   447  O O   . GLU A 1 62  ? -14.672 -3.029  18.903 1.00 23.04  ? 62  GLU A O   1 ? 
ATOM   448  C CB  . GLU A 1 62  ? -17.896 -2.082  19.417 1.00 32.10  ? 62  GLU A CB  1 ? 
ATOM   449  C CG  . GLU A 1 62  ? -17.135 -0.916  19.987 1.00 58.37  ? 62  GLU A CG  1 ? 
ATOM   450  C CD  . GLU A 1 62  ? -17.989 0.330   20.288 1.00 48.18  ? 62  GLU A CD  1 ? 
ATOM   451  O OE1 . GLU A 1 62  ? -18.927 0.269   21.121 1.00 42.45  ? 62  GLU A OE1 1 ? 
ATOM   452  O OE2 . GLU A 1 62  ? -17.662 1.375   19.699 1.00 35.41  ? 62  GLU A OE2 1 ? 
ATOM   453  N N   . LEU A 1 63  ? -15.577 -3.891  20.738 1.00 23.08  ? 63  LEU A N   1 ? 
ATOM   454  C CA  . LEU A 1 63  ? -14.265 -3.958  21.382 1.00 23.75  ? 63  LEU A CA  1 ? 
ATOM   455  C C   . LEU A 1 63  ? -13.381 -4.998  20.706 1.00 25.03  ? 63  LEU A C   1 ? 
ATOM   456  O O   . LEU A 1 63  ? -12.221 -4.724  20.387 1.00 25.80  ? 63  LEU A O   1 ? 
ATOM   457  C CB  . LEU A 1 63  ? -14.401 -4.306  22.852 1.00 25.34  ? 63  LEU A CB  1 ? 
ATOM   458  C CG  . LEU A 1 63  ? -13.153 -4.411  23.707 1.00 35.11  ? 63  LEU A CG  1 ? 
ATOM   459  C CD1 . LEU A 1 63  ? -12.310 -3.219  23.448 1.00 32.96  ? 63  LEU A CD1 1 ? 
ATOM   460  C CD2 . LEU A 1 63  ? -13.639 -4.494  25.140 1.00 35.71  ? 63  LEU A CD2 1 ? 
ATOM   461  N N   A VAL A 1 64  ? -13.904 -6.203  20.490 0.46 21.42  ? 64  VAL A N   1 ? 
ATOM   462  N N   B VAL A 1 64  ? -13.914 -6.200  20.475 0.54 23.45  ? 64  VAL A N   1 ? 
ATOM   463  C CA  A VAL A 1 64  ? -13.078 -7.246  19.891 0.46 23.11  ? 64  VAL A CA  1 ? 
ATOM   464  C CA  B VAL A 1 64  ? -13.092 -7.257  19.890 0.54 22.18  ? 64  VAL A CA  1 ? 
ATOM   465  C C   A VAL A 1 64  ? -12.725 -6.874  18.460 0.46 22.77  ? 64  VAL A C   1 ? 
ATOM   466  C C   B VAL A 1 64  ? -12.745 -6.906  18.455 0.54 21.50  ? 64  VAL A C   1 ? 
ATOM   467  O O   A VAL A 1 64  ? -11.593 -7.097  18.012 0.46 24.31  ? 64  VAL A O   1 ? 
ATOM   468  O O   B VAL A 1 64  ? -11.621 -7.154  18.007 0.54 24.35  ? 64  VAL A O   1 ? 
ATOM   469  C CB  A VAL A 1 64  ? -13.775 -8.614  19.993 0.46 24.93  ? 64  VAL A CB  1 ? 
ATOM   470  C CB  B VAL A 1 64  ? -13.790 -8.626  20.036 0.54 25.03  ? 64  VAL A CB  1 ? 
ATOM   471  C CG1 A VAL A 1 64  ? -13.069 -9.601  19.107 0.46 24.68  ? 64  VAL A CG1 1 ? 
ATOM   472  C CG1 B VAL A 1 64  ? -14.970 -8.789  19.094 0.54 17.73  ? 64  VAL A CG1 1 ? 
ATOM   473  C CG2 A VAL A 1 64  ? -13.770 -9.093  21.455 0.46 24.25  ? 64  VAL A CG2 1 ? 
ATOM   474  C CG2 B VAL A 1 64  ? -12.780 -9.723  19.843 0.54 25.23  ? 64  VAL A CG2 1 ? 
ATOM   475  N N   . ILE A 1 65  ? -13.663 -6.259  17.732 1.00 21.36  ? 65  ILE A N   1 ? 
ATOM   476  C CA  . ILE A 1 65  ? -13.361 -5.855  16.356 1.00 17.97  ? 65  ILE A CA  1 ? 
ATOM   477  C C   . ILE A 1 65  ? -12.181 -4.879  16.310 1.00 26.75  ? 65  ILE A C   1 ? 
ATOM   478  O O   . ILE A 1 65  ? -11.288 -4.975  15.448 1.00 19.44  ? 65  ILE A O   1 ? 
ATOM   479  C CB  . ILE A 1 65  ? -14.599 -5.257  15.686 1.00 23.41  ? 65  ILE A CB  1 ? 
ATOM   480  C CG1 . ILE A 1 65  ? -15.617 -6.353  15.335 1.00 23.17  ? 65  ILE A CG1 1 ? 
ATOM   481  C CG2 . ILE A 1 65  ? -14.198 -4.520  14.442 1.00 31.06  ? 65  ILE A CG2 1 ? 
ATOM   482  C CD1 . ILE A 1 65  ? -17.010 -5.839  14.884 1.00 23.59  ? 65  ILE A CD1 1 ? 
ATOM   483  N N   . ALA A 1 66  ? -12.179 -3.900  17.200 1.00 22.39  ? 66  ALA A N   1 ? 
ATOM   484  C CA  . ALA A 1 66  ? -11.079 -2.951  17.253 1.00 27.43  ? 66  ALA A CA  1 ? 
ATOM   485  C C   . ALA A 1 66  ? -9.767  -3.632  17.600 1.00 24.97  ? 66  ALA A C   1 ? 
ATOM   486  O O   . ALA A 1 66  ? -8.720  -3.323  17.006 1.00 26.76  ? 66  ALA A O   1 ? 
ATOM   487  C CB  . ALA A 1 66  ? -11.380 -1.854  18.279 1.00 30.01  ? 66  ALA A CB  1 ? 
ATOM   488  N N   . LEU A 1 67  ? -9.775  -4.518  18.592 1.00 24.25  ? 67  LEU A N   1 ? 
ATOM   489  C CA  . LEU A 1 67  ? -8.515  -5.155  18.959 1.00 26.00  ? 67  LEU A CA  1 ? 
ATOM   490  C C   . LEU A 1 67  ? -7.937  -5.890  17.772 1.00 27.89  ? 67  LEU A C   1 ? 
ATOM   491  O O   . LEU A 1 67  ? -6.717  -5.940  17.577 1.00 26.82  ? 67  LEU A O   1 ? 
ATOM   492  C CB  . LEU A 1 67  ? -8.725  -6.148  20.096 1.00 23.59  ? 67  LEU A CB  1 ? 
ATOM   493  C CG  . LEU A 1 67  ? -8.370  -5.912  21.563 1.00 34.90  ? 67  LEU A CG  1 ? 
ATOM   494  C CD1 . LEU A 1 67  ? -8.914  -7.171  22.259 1.00 35.18  ? 67  LEU A CD1 1 ? 
ATOM   495  C CD2 . LEU A 1 67  ? -6.900  -5.754  21.805 1.00 40.02  ? 67  LEU A CD2 1 ? 
ATOM   496  N N   . VAL A 1 68  ? -8.807  -6.555  17.022 1.00 23.60  ? 68  VAL A N   1 ? 
ATOM   497  C CA  . VAL A 1 68  ? -8.345  -7.338  15.899 1.00 20.10  ? 68  VAL A CA  1 ? 
ATOM   498  C C   . VAL A 1 68  ? -7.852  -6.442  14.782 1.00 23.74  ? 68  VAL A C   1 ? 
ATOM   499  O O   . VAL A 1 68  ? -6.874  -6.761  14.100 1.00 25.13  ? 68  VAL A O   1 ? 
ATOM   500  C CB  . VAL A 1 68  ? -9.459  -8.268  15.390 1.00 21.31  ? 68  VAL A CB  1 ? 
ATOM   501  C CG1 . VAL A 1 68  ? -9.003  -8.868  14.103 1.00 19.49  ? 68  VAL A CG1 1 ? 
ATOM   502  C CG2 . VAL A 1 68  ? -9.795  -9.396  16.345 1.00 20.23  ? 68  VAL A CG2 1 ? 
ATOM   503  N N   . LYS A 1 69  ? -8.550  -5.342  14.524 1.00 20.97  ? 69  LYS A N   1 ? 
ATOM   504  C CA  . LYS A 1 69  ? -8.132  -4.484  13.415 1.00 21.78  ? 69  LYS A CA  1 ? 
ATOM   505  C C   . LYS A 1 69  ? -6.742  -3.929  13.667 1.00 26.58  ? 69  LYS A C   1 ? 
ATOM   506  O O   . LYS A 1 69  ? -5.924  -3.814  12.744 1.00 25.29  ? 69  LYS A O   1 ? 
ATOM   507  C CB  . LYS A 1 69  ? -9.120  -3.350  13.215 1.00 21.11  ? 69  LYS A CB  1 ? 
ATOM   508  C CG  . LYS A 1 69  ? -10.232 -3.678  12.248 1.00 37.80  ? 69  LYS A CG  1 ? 
ATOM   509  C CD  . LYS A 1 69  ? -10.914 -2.409  11.706 1.00 44.11  ? 69  LYS A CD  1 ? 
ATOM   510  C CE  . LYS A 1 69  ? -12.292 -2.716  11.064 1.00 47.08  ? 69  LYS A CE  1 ? 
ATOM   511  N NZ  . LYS A 1 69  ? -12.789 -1.676  10.079 1.00 64.39  ? 69  LYS A NZ  1 ? 
ATOM   512  N N   . GLU A 1 70  ? -6.458  -3.609  14.926 1.00 23.39  ? 70  GLU A N   1 ? 
ATOM   513  C CA  . GLU A 1 70  ? -5.151  -3.101  15.323 1.00 29.37  ? 70  GLU A CA  1 ? 
ATOM   514  C C   . GLU A 1 70  ? -4.088  -4.182  15.201 1.00 37.65  ? 70  GLU A C   1 ? 
ATOM   515  O O   . GLU A 1 70  ? -2.998  -3.928  14.673 1.00 37.98  ? 70  GLU A O   1 ? 
ATOM   516  C CB  . GLU A 1 70  ? -5.240  -2.593  16.747 1.00 29.96  ? 70  GLU A CB  1 ? 
ATOM   517  C CG  . GLU A 1 70  ? -4.053  -1.803  17.250 1.00 49.30  ? 70  GLU A CG  1 ? 
ATOM   518  C CD  . GLU A 1 70  ? -4.243  -1.412  18.699 1.00 82.60  ? 70  GLU A CD  1 ? 
ATOM   519  O OE1 . GLU A 1 70  ? -4.150  -2.307  19.578 1.00 63.35  ? 70  GLU A OE1 1 ? 
ATOM   520  O OE2 . GLU A 1 70  ? -4.536  -0.222  18.948 1.00 90.98  ? 70  GLU A OE2 1 ? 
ATOM   521  N N   . ARG A 1 71  ? -4.395  -5.410  15.650 1.00 29.81  ? 71  ARG A N   1 ? 
ATOM   522  C CA  . ARG A 1 71  ? -3.410  -6.482  15.545 1.00 24.00  ? 71  ARG A CA  1 ? 
ATOM   523  C C   . ARG A 1 71  ? -3.046  -6.774  14.107 1.00 31.33  ? 71  ARG A C   1 ? 
ATOM   524  O O   . ARG A 1 71  ? -1.885  -7.045  13.801 1.00 35.53  ? 71  ARG A O   1 ? 
ATOM   525  C CB  . ARG A 1 71  ? -3.904  -7.756  16.207 1.00 30.10  ? 71  ARG A CB  1 ? 
ATOM   526  C CG  . ARG A 1 71  ? -2.887  -8.865  16.100 1.00 35.92  ? 71  ARG A CG  1 ? 
ATOM   527  C CD  . ARG A 1 71  ? -1.607  -8.524  16.856 1.00 36.06  ? 71  ARG A CD  1 ? 
ATOM   528  N NE  . ARG A 1 71  ? -0.705  -9.659  16.824 1.00 34.90  ? 71  ARG A NE  1 ? 
ATOM   529  C CZ  . ARG A 1 71  ? 0.176   -9.902  15.864 1.00 33.98  ? 71  ARG A CZ  1 ? 
ATOM   530  N NH1 . ARG A 1 71  ? 0.308   -9.060  14.852 1.00 43.07  ? 71  ARG A NH1 1 ? 
ATOM   531  N NH2 . ARG A 1 71  ? 0.930   -10.992 15.908 1.00 46.25  ? 71  ARG A NH2 1 ? 
ATOM   532  N N   . ILE A 1 72  ? -4.017  -6.793  13.203 1.00 31.07  ? 72  ILE A N   1 ? 
ATOM   533  C CA  . ILE A 1 72  ? -3.672  -7.287  11.876 1.00 28.94  ? 72  ILE A CA  1 ? 
ATOM   534  C C   . ILE A 1 72  ? -3.073  -6.233  10.969 1.00 34.86  ? 72  ILE A C   1 ? 
ATOM   535  O O   . ILE A 1 72  ? -2.683  -6.558  9.839  1.00 29.52  ? 72  ILE A O   1 ? 
ATOM   536  C CB  . ILE A 1 72  ? -4.865  -7.855  11.090 1.00 33.81  ? 72  ILE A CB  1 ? 
ATOM   537  C CG1 . ILE A 1 72  ? -5.940  -6.778  10.977 1.00 38.42  ? 72  ILE A CG1 1 ? 
ATOM   538  C CG2 . ILE A 1 72  ? -5.375  -9.058  11.763 1.00 41.73  ? 72  ILE A CG2 1 ? 
ATOM   539  C CD1 . ILE A 1 72  ? -7.010  -7.032  9.951  1.00 48.74  ? 72  ILE A CD1 1 ? 
ATOM   540  N N   . ALA A 1 73  ? -3.077  -4.970  11.392 1.00 34.81  ? 73  ALA A N   1 ? 
ATOM   541  C CA  . ALA A 1 73  ? -2.431  -3.925  10.617 1.00 38.84  ? 73  ALA A CA  1 ? 
ATOM   542  C C   . ALA A 1 73  ? -0.924  -3.947  10.801 1.00 45.35  ? 73  ALA A C   1 ? 
ATOM   543  O O   . ALA A 1 73  ? -0.221  -3.268  10.041 1.00 41.48  ? 73  ALA A O   1 ? 
ATOM   544  C CB  . ALA A 1 73  ? -2.968  -2.542  10.993 1.00 37.06  ? 73  ALA A CB  1 ? 
ATOM   545  N N   . GLN A 1 74  ? -0.423  -4.701  11.784 1.00 33.99  ? 74  GLN A N   1 ? 
ATOM   546  C CA  . GLN A 1 74  ? 1.012   -4.775  12.020 1.00 44.25  ? 74  GLN A CA  1 ? 
ATOM   547  C C   . GLN A 1 74  ? 1.698   -5.530  10.888 1.00 33.18  ? 74  GLN A C   1 ? 
ATOM   548  O O   . GLN A 1 74  ? 1.078   -6.346  10.201 1.00 30.97  ? 74  GLN A O   1 ? 
ATOM   549  C CB  . GLN A 1 74  ? 1.290   -5.445  13.357 1.00 37.08  ? 74  GLN A CB  1 ? 
ATOM   550  C CG  . GLN A 1 74  ? 0.626   -4.763  14.529 1.00 42.42  ? 74  GLN A CG  1 ? 
ATOM   551  C CD  . GLN A 1 74  ? 0.942   -5.462  15.813 1.00 62.75  ? 74  GLN A CD  1 ? 
ATOM   552  O OE1 . GLN A 1 74  ? 2.047   -5.977  15.984 1.00 78.05  ? 74  GLN A OE1 1 ? 
ATOM   553  N NE2 . GLN A 1 74  ? -0.018  -5.495  16.732 1.00 58.15  ? 74  GLN A NE2 1 ? 
ATOM   554  N N   . GLU A 1 75  ? 2.996   -5.242  10.683 1.00 39.46  ? 75  GLU A N   1 ? 
ATOM   555  C CA  . GLU A 1 75  ? 3.679   -5.751  9.486  1.00 44.05  ? 75  GLU A CA  1 ? 
ATOM   556  C C   . GLU A 1 75  ? 3.803   -7.279  9.487  1.00 41.31  ? 75  GLU A C   1 ? 
ATOM   557  O O   . GLU A 1 75  ? 3.804   -7.895  8.408  1.00 39.68  ? 75  GLU A O   1 ? 
ATOM   558  C CB  . GLU A 1 75  ? 5.070   -5.125  9.337  1.00 55.50  ? 75  GLU A CB  1 ? 
ATOM   559  C CG  . GLU A 1 75  ? 5.925   -5.727  8.181  1.00 62.53  ? 75  GLU A CG  1 ? 
ATOM   560  C CD  . GLU A 1 75  ? 5.347   -5.490  6.782  1.00 73.38  ? 75  GLU A CD  1 ? 
ATOM   561  O OE1 . GLU A 1 75  ? 4.473   -4.602  6.633  1.00 65.55  ? 75  GLU A OE1 1 ? 
ATOM   562  O OE2 . GLU A 1 75  ? 5.786   -6.183  5.828  1.00 70.52  ? 75  GLU A OE2 1 ? 
ATOM   563  N N   . ASP A 1 76  ? 3.916   -7.908  10.670 1.00 30.96  ? 76  ASP A N   1 ? 
ATOM   564  C CA  . ASP A 1 76  ? 4.064   -9.366  10.746 1.00 39.77  ? 76  ASP A CA  1 ? 
ATOM   565  C C   . ASP A 1 76  ? 2.803   -10.130 10.332 1.00 41.74  ? 76  ASP A C   1 ? 
ATOM   566  O O   . ASP A 1 76  ? 2.870   -11.358 10.209 1.00 30.94  ? 76  ASP A O   1 ? 
ATOM   567  C CB  . ASP A 1 76  ? 4.488   -9.772  12.162 1.00 39.03  ? 76  ASP A CB  1 ? 
ATOM   568  C CG  . ASP A 1 76  ? 3.352   -9.725  13.166 1.00 50.55  ? 76  ASP A CG  1 ? 
ATOM   569  O OD1 . ASP A 1 76  ? 2.448   -8.874  13.009 1.00 50.50  ? 76  ASP A OD1 1 ? 
ATOM   570  O OD2 . ASP A 1 76  ? 3.368   -10.545 14.124 1.00 41.27  ? 76  ASP A OD2 1 ? 
ATOM   571  N N   . CYS A 1 77  ? 1.673   -9.446  10.085 1.00 40.25  ? 77  CYS A N   1 ? 
ATOM   572  C CA  . CYS A 1 77  ? 0.496   -10.062 9.460  1.00 35.62  ? 77  CYS A CA  1 ? 
ATOM   573  C C   . CYS A 1 77  ? 0.399   -9.827  7.963  1.00 36.78  ? 77  CYS A C   1 ? 
ATOM   574  O O   . CYS A 1 77  ? -0.628  -10.177 7.365  1.00 28.56  ? 77  CYS A O   1 ? 
ATOM   575  C CB  . CYS A 1 77  ? -0.804  -9.541  10.071 1.00 31.56  ? 77  CYS A CB  1 ? 
ATOM   576  S SG  . CYS A 1 77  ? -0.921  -9.986  11.799 1.00 38.14  ? 77  CYS A SG  1 ? 
ATOM   577  N N   . ARG A 1 78  ? 1.394   -9.165  7.370  1.00 37.89  ? 78  ARG A N   1 ? 
ATOM   578  C CA  . ARG A 1 78  ? 1.382   -8.890  5.935  1.00 47.57  ? 78  ARG A CA  1 ? 
ATOM   579  C C   . ARG A 1 78  ? 1.131   -10.155 5.114  1.00 39.22  ? 78  ARG A C   1 ? 
ATOM   580  O O   . ARG A 1 78  ? 0.289   -10.160 4.206  1.00 36.98  ? 78  ARG A O   1 ? 
ATOM   581  C CB  . ARG A 1 78  ? 2.714   -8.224  5.545  1.00 60.28  ? 78  ARG A CB  1 ? 
ATOM   582  C CG  . ARG A 1 78  ? 2.762   -7.533  4.172  1.00 91.66  ? 78  ARG A CG  1 ? 
ATOM   583  C CD  . ARG A 1 78  ? 3.396   -8.418  3.077  1.00 112.34 ? 78  ARG A CD  1 ? 
ATOM   584  N NE  . ARG A 1 78  ? 4.851   -8.268  2.934  1.00 92.21  ? 78  ARG A NE  1 ? 
ATOM   585  C CZ  . ARG A 1 78  ? 5.569   -8.784  1.932  1.00 89.35  ? 78  ARG A CZ  1 ? 
ATOM   586  N NH1 . ARG A 1 78  ? 4.984   -9.487  0.965  1.00 77.27  ? 78  ARG A NH1 1 ? 
ATOM   587  N NH2 . ARG A 1 78  ? 6.883   -8.593  1.891  1.00 71.23  ? 78  ARG A NH2 1 ? 
ATOM   588  N N   . ASN A 1 79  ? 1.831   -11.247 5.414  1.00 33.32  ? 79  ASN A N   1 ? 
ATOM   589  C CA  . ASN A 1 79  ? 1.725   -12.443 4.583  1.00 35.07  ? 79  ASN A CA  1 ? 
ATOM   590  C C   . ASN A 1 79  ? 0.796   -13.505 5.163  1.00 31.19  ? 79  ASN A C   1 ? 
ATOM   591  O O   . ASN A 1 79  ? 0.964   -14.690 4.880  1.00 39.17  ? 79  ASN A O   1 ? 
ATOM   592  C CB  . ASN A 1 79  ? 3.118   -12.992 4.339  1.00 43.05  ? 79  ASN A CB  1 ? 
ATOM   593  C CG  . ASN A 1 79  ? 3.967   -11.995 3.610  1.00 61.89  ? 79  ASN A CG  1 ? 
ATOM   594  O OD1 . ASN A 1 79  ? 3.601   -11.546 2.524  1.00 50.37  ? 79  ASN A OD1 1 ? 
ATOM   595  N ND2 . ASN A 1 79  ? 5.043   -11.552 4.245  1.00 60.44  ? 79  ASN A ND2 1 ? 
ATOM   596  N N   . GLY A 1 80  ? -0.212  -13.103 5.916  1.00 30.79  ? 80  GLY A N   1 ? 
ATOM   597  C CA  . GLY A 1 80  ? -1.225  -14.020 6.401  1.00 31.20  ? 80  GLY A CA  1 ? 
ATOM   598  C C   . GLY A 1 80  ? -1.222  -14.124 7.910  1.00 24.67  ? 80  GLY A C   1 ? 
ATOM   599  O O   . GLY A 1 80  ? -0.374  -13.572 8.602  1.00 22.17  ? 80  GLY A O   1 ? 
ATOM   600  N N   . PHE A 1 81  ? -2.233  -14.826 8.411  1.00 24.00  ? 81  PHE A N   1 ? 
ATOM   601  C CA  . PHE A 1 81  ? -2.423  -14.941 9.850  1.00 19.86  ? 81  PHE A CA  1 ? 
ATOM   602  C C   . PHE A 1 81  ? -3.504  -15.992 10.086 1.00 21.84  ? 81  PHE A C   1 ? 
ATOM   603  O O   . PHE A 1 81  ? -4.232  -16.383 9.173  1.00 21.93  ? 81  PHE A O   1 ? 
ATOM   604  C CB  . PHE A 1 81  ? -2.792  -13.606 10.503 1.00 24.64  ? 81  PHE A CB  1 ? 
ATOM   605  C CG  . PHE A 1 81  ? -3.861  -12.852 9.751  1.00 33.35  ? 81  PHE A CG  1 ? 
ATOM   606  C CD1 . PHE A 1 81  ? -5.184  -13.225 9.872  1.00 28.25  ? 81  PHE A CD1 1 ? 
ATOM   607  C CD2 . PHE A 1 81  ? -3.542  -11.800 8.887  1.00 37.93  ? 81  PHE A CD2 1 ? 
ATOM   608  C CE1 . PHE A 1 81  ? -6.190  -12.576 9.143  1.00 39.57  ? 81  PHE A CE1 1 ? 
ATOM   609  C CE2 . PHE A 1 81  ? -4.553  -11.136 8.159  1.00 33.58  ? 81  PHE A CE2 1 ? 
ATOM   610  C CZ  . PHE A 1 81  ? -5.869  -11.530 8.296  1.00 33.11  ? 81  PHE A CZ  1 ? 
ATOM   611  N N   . LEU A 1 82  ? -3.560  -16.482 11.307 1.00 19.31  ? 82  LEU A N   1 ? 
ATOM   612  C CA  . LEU A 1 82  ? -4.526  -17.513 11.709 1.00 16.43  ? 82  LEU A CA  1 ? 
ATOM   613  C C   . LEU A 1 82  ? -5.470  -16.912 12.740 1.00 23.03  ? 82  LEU A C   1 ? 
ATOM   614  O O   . LEU A 1 82  ? -4.985  -16.593 13.774 1.00 19.42  ? 82  LEU A O   1 ? 
ATOM   615  C CB  . LEU A 1 82  ? -3.774  -18.703 12.289 1.00 21.85  ? 82  LEU A CB  1 ? 
ATOM   616  C CG  . LEU A 1 82  ? -4.657  -19.906 12.561 1.00 32.27  ? 82  LEU A CG  1 ? 
ATOM   617  C CD1 . LEU A 1 82  ? -3.993  -21.184 12.108 1.00 30.51  ? 82  LEU A CD1 1 ? 
ATOM   618  C CD2 . LEU A 1 82  ? -5.024  -19.970 14.023 1.00 38.05  ? 82  LEU A CD2 1 ? 
ATOM   619  N N   . LEU A 1 83  ? -6.742  -16.718 12.432 1.00 16.78  ? 83  LEU A N   1 ? 
ATOM   620  C CA  . LEU A 1 83  ? -7.746  -16.210 13.394 1.00 22.30  ? 83  LEU A CA  1 ? 
ATOM   621  C C   . LEU A 1 83  ? -8.237  -17.366 14.282 1.00 20.22  ? 83  LEU A C   1 ? 
ATOM   622  O O   . LEU A 1 83  ? -8.759  -18.315 13.749 1.00 20.37  ? 83  LEU A O   1 ? 
ATOM   623  C CB  . LEU A 1 83  ? -8.886  -15.576 12.607 1.00 16.23  ? 83  LEU A CB  1 ? 
ATOM   624  C CG  . LEU A 1 83  ? -8.500  -14.291 11.908 1.00 18.27  ? 83  LEU A CG  1 ? 
ATOM   625  C CD1 . LEU A 1 83  ? -9.607  -13.803 11.009 1.00 25.84  ? 83  LEU A CD1 1 ? 
ATOM   626  C CD2 . LEU A 1 83  ? -8.135  -13.255 12.933 1.00 25.54  ? 83  LEU A CD2 1 ? 
ATOM   627  N N   . ASP A 1 84  ? -8.103  -17.263 15.599 1.00 24.33  ? 84  ASP A N   1 ? 
ATOM   628  C CA  . ASP A 1 84  ? -8.477  -18.322 16.563 1.00 24.43  ? 84  ASP A CA  1 ? 
ATOM   629  C C   . ASP A 1 84  ? -9.377  -17.709 17.637 1.00 26.14  ? 84  ASP A C   1 ? 
ATOM   630  O O   . ASP A 1 84  ? -8.833  -17.127 18.554 1.00 26.23  ? 84  ASP A O   1 ? 
ATOM   631  C CB  . ASP A 1 84  ? -7.203  -18.911 17.153 1.00 27.86  ? 84  ASP A CB  1 ? 
ATOM   632  C CG  . ASP A 1 84  ? -7.440  -20.050 18.113 1.00 37.69  ? 84  ASP A CG  1 ? 
ATOM   633  O OD1 . ASP A 1 84  ? -8.589  -20.444 18.249 1.00 40.63  ? 84  ASP A OD1 1 ? 
ATOM   634  O OD2 . ASP A 1 84  ? -6.467  -20.532 18.683 1.00 32.39  ? 84  ASP A OD2 1 ? 
ATOM   635  N N   . GLY A 1 85  ? -10.693 -17.854 17.540 1.00 25.59  ? 85  GLY A N   1 ? 
ATOM   636  C CA  . GLY A 1 85  ? -11.600 -17.228 18.487 1.00 28.70  ? 85  GLY A CA  1 ? 
ATOM   637  C C   . GLY A 1 85  ? -12.297 -15.989 17.974 1.00 24.92  ? 85  GLY A C   1 ? 
ATOM   638  O O   . GLY A 1 85  ? -13.081 -15.379 18.720 1.00 28.75  ? 85  GLY A O   1 ? 
ATOM   639  N N   . PHE A 1 86  ? -12.031 -15.595 16.732 1.00 20.79  ? 86  PHE A N   1 ? 
ATOM   640  C CA  . PHE A 1 86  ? -12.648 -14.477 16.020 1.00 23.12  ? 86  PHE A CA  1 ? 
ATOM   641  C C   . PHE A 1 86  ? -12.785 -14.910 14.570 1.00 19.48  ? 86  PHE A C   1 ? 
ATOM   642  O O   . PHE A 1 86  ? -11.867 -15.557 14.042 1.00 20.90  ? 86  PHE A O   1 ? 
ATOM   643  C CB  . PHE A 1 86  ? -11.760 -13.240 16.086 1.00 21.66  ? 86  PHE A CB  1 ? 
ATOM   644  C CG  . PHE A 1 86  ? -12.320 -12.028 15.393 1.00 20.80  ? 86  PHE A CG  1 ? 
ATOM   645  C CD1 . PHE A 1 86  ? -12.960 -11.047 16.133 1.00 22.79  ? 86  PHE A CD1 1 ? 
ATOM   646  C CD2 . PHE A 1 86  ? -12.173 -11.833 14.018 1.00 18.51  ? 86  PHE A CD2 1 ? 
ATOM   647  C CE1 . PHE A 1 86  ? -13.468 -9.889  15.517 1.00 25.88  ? 86  PHE A CE1 1 ? 
ATOM   648  C CE2 . PHE A 1 86  ? -12.677 -10.690 13.417 1.00 23.23  ? 86  PHE A CE2 1 ? 
ATOM   649  C CZ  . PHE A 1 86  ? -13.321 -9.722  14.177 1.00 23.04  ? 86  PHE A CZ  1 ? 
ATOM   650  N N   . PRO A 1 87  ? -13.908 -14.604 13.895 1.00 17.53  ? 87  PRO A N   1 ? 
ATOM   651  C CA  . PRO A 1 87  ? -15.171 -14.026 14.323 1.00 15.30  ? 87  PRO A CA  1 ? 
ATOM   652  C C   . PRO A 1 87  ? -15.876 -15.015 15.218 1.00 20.01  ? 87  PRO A C   1 ? 
ATOM   653  O O   . PRO A 1 87  ? -15.746 -16.236 15.064 1.00 20.49  ? 87  PRO A O   1 ? 
ATOM   654  C CB  . PRO A 1 87  ? -15.928 -13.800 13.000 1.00 18.62  ? 87  PRO A CB  1 ? 
ATOM   655  C CG  . PRO A 1 87  ? -15.431 -14.920 12.117 1.00 23.51  ? 87  PRO A CG  1 ? 
ATOM   656  C CD  . PRO A 1 87  ? -13.981 -15.089 12.500 1.00 21.89  ? 87  PRO A CD  1 ? 
ATOM   657  N N   . ARG A 1 88  ? -16.582 -14.483 16.192 1.00 19.75  ? 88  ARG A N   1 ? 
ATOM   658  C CA  . ARG A 1 88  ? -17.383 -15.284 17.097 1.00 23.80  ? 88  ARG A CA  1 ? 
ATOM   659  C C   . ARG A 1 88  ? -18.851 -14.911 17.039 1.00 21.20  ? 88  ARG A C   1 ? 
ATOM   660  O O   . ARG A 1 88  ? -19.661 -15.530 17.722 1.00 18.08  ? 88  ARG A O   1 ? 
ATOM   661  C CB  . ARG A 1 88  ? -16.879 -15.127 18.531 1.00 24.78  ? 88  ARG A CB  1 ? 
ATOM   662  C CG  . ARG A 1 88  ? -16.461 -16.451 19.137 1.00 33.72  ? 88  ARG A CG  1 ? 
ATOM   663  C CD  . ARG A 1 88  ? -16.122 -16.072 20.480 1.00 36.26  ? 88  ARG A CD  1 ? 
ATOM   664  N NE  . ARG A 1 88  ? -16.005 -17.095 21.493 1.00 37.29  ? 88  ARG A NE  1 ? 
ATOM   665  C CZ  . ARG A 1 88  ? -14.847 -17.589 21.893 1.00 37.34  ? 88  ARG A CZ  1 ? 
ATOM   666  N NH1 . ARG A 1 88  ? -14.820 -18.446 22.896 1.00 48.05  ? 88  ARG A NH1 1 ? 
ATOM   667  N NH2 . ARG A 1 88  ? -13.718 -17.207 21.280 1.00 24.45  ? 88  ARG A NH2 1 ? 
ATOM   668  N N   . THR A 1 89  ? -19.221 -13.930 16.219 1.00 20.30  ? 89  THR A N   1 ? 
ATOM   669  C CA  . THR A 1 89  ? -20.618 -13.657 15.945 1.00 20.03  ? 89  THR A CA  1 ? 
ATOM   670  C C   . THR A 1 89  ? -20.776 -13.237 14.484 1.00 15.88  ? 89  THR A C   1 ? 
ATOM   671  O O   . THR A 1 89  ? -19.811 -12.937 13.784 1.00 17.21  ? 89  THR A O   1 ? 
ATOM   672  C CB  . THR A 1 89  ? -21.172 -12.550 16.852 1.00 20.73  ? 89  THR A CB  1 ? 
ATOM   673  O OG1 . THR A 1 89  ? -20.569 -11.306 16.489 1.00 24.94  ? 89  THR A OG1 1 ? 
ATOM   674  C CG2 . THR A 1 89  ? -20.856 -12.797 18.288 1.00 24.44  ? 89  THR A CG2 1 ? 
ATOM   675  N N   . ILE A 1 90  ? -22.005 -13.224 14.017 1.00 22.11  ? 90  ILE A N   1 ? 
ATOM   676  C CA  . ILE A 1 90  ? -22.263 -12.764 12.656 1.00 21.78  ? 90  ILE A CA  1 ? 
ATOM   677  C C   . ILE A 1 90  ? -21.797 -11.321 12.446 1.00 21.78  ? 90  ILE A C   1 ? 
ATOM   678  O O   . ILE A 1 90  ? -21.129 -11.057 11.432 1.00 21.93  ? 90  ILE A O   1 ? 
ATOM   679  C CB  . ILE A 1 90  ? -23.743 -12.960 12.297 1.00 26.59  ? 90  ILE A CB  1 ? 
ATOM   680  C CG1 . ILE A 1 90  ? -24.144 -14.438 12.308 1.00 32.20  ? 90  ILE A CG1 1 ? 
ATOM   681  C CG2 . ILE A 1 90  ? -24.008 -12.274 10.959 1.00 25.77  ? 90  ILE A CG2 1 ? 
ATOM   682  C CD1 . ILE A 1 90  ? -23.758 -15.167 11.105 1.00 48.56  ? 90  ILE A CD1 1 ? 
ATOM   683  N N   . PRO A 1 91  ? -22.124 -10.361 13.323 1.00 24.29  ? 91  PRO A N   1 ? 
ATOM   684  C CA  . PRO A 1 91  ? -21.581 -8.998  13.170 1.00 23.85  ? 91  PRO A CA  1 ? 
ATOM   685  C C   . PRO A 1 91  ? -20.065 -8.921  13.062 1.00 22.10  ? 91  PRO A C   1 ? 
ATOM   686  O O   . PRO A 1 91  ? -19.538 -8.064  12.340 1.00 25.85  ? 91  PRO A O   1 ? 
ATOM   687  C CB  . PRO A 1 91  ? -22.071 -8.284  14.444 1.00 24.74  ? 91  PRO A CB  1 ? 
ATOM   688  C CG  . PRO A 1 91  ? -23.250 -9.012  14.863 1.00 25.33  ? 91  PRO A CG  1 ? 
ATOM   689  C CD  . PRO A 1 91  ? -23.085 -10.442 14.432 1.00 26.83  ? 91  PRO A CD  1 ? 
ATOM   690  N N   . GLN A 1 92  ? -19.347 -9.764  13.793 1.00 17.98  ? 92  GLN A N   1 ? 
ATOM   691  C CA  . GLN A 1 92  ? -17.893 -9.785  13.677 1.00 22.44  ? 92  GLN A CA  1 ? 
ATOM   692  C C   . GLN A 1 92  ? -17.443 -10.282 12.309 1.00 18.69  ? 92  GLN A C   1 ? 
ATOM   693  O O   . GLN A 1 92  ? -16.463 -9.774  11.746 1.00 19.01  ? 92  GLN A O   1 ? 
ATOM   694  C CB  . GLN A 1 92  ? -17.326 -10.648 14.785 1.00 20.97  ? 92  GLN A CB  1 ? 
ATOM   695  C CG  . GLN A 1 92  ? -17.393 -10.004 16.149 1.00 20.45  ? 92  GLN A CG  1 ? 
ATOM   696  C CD  . GLN A 1 92  ? -16.844 -10.941 17.193 1.00 18.65  ? 92  GLN A CD  1 ? 
ATOM   697  O OE1 . GLN A 1 92  ? -15.977 -11.739 16.921 1.00 19.04  ? 92  GLN A OE1 1 ? 
ATOM   698  N NE2 . GLN A 1 92  ? -17.377 -10.847 18.409 1.00 17.55  ? 92  GLN A NE2 1 ? 
ATOM   699  N N   . ALA A 1 93  ? -18.127 -11.281 11.764 1.00 23.16  ? 93  ALA A N   1 ? 
ATOM   700  C CA  . ALA A 1 93  ? -17.807 -11.743 10.417 1.00 24.21  ? 93  ALA A CA  1 ? 
ATOM   701  C C   . ALA A 1 93  ? -18.159 -10.674 9.385  1.00 24.83  ? 93  ALA A C   1 ? 
ATOM   702  O O   . ALA A 1 93  ? -17.409 -10.461 8.416  1.00 22.49  ? 93  ALA A O   1 ? 
ATOM   703  C CB  . ALA A 1 93  ? -18.544 -13.052 10.126 1.00 18.35  ? 93  ALA A CB  1 ? 
ATOM   704  N N   . ASP A 1 94  ? -19.282 -9.976  9.586  1.00 22.46  ? 94  ASP A N   1 ? 
ATOM   705  C CA  . ASP A 1 94  ? -19.661 -8.905  8.665  1.00 26.07  ? 94  ASP A CA  1 ? 
ATOM   706  C C   . ASP A 1 94  ? -18.609 -7.795  8.644  1.00 25.11  ? 94  ASP A C   1 ? 
ATOM   707  O O   . ASP A 1 94  ? -18.302 -7.236  7.583  1.00 23.47  ? 94  ASP A O   1 ? 
ATOM   708  C CB  . ASP A 1 94  ? -21.048 -8.363  9.052  1.00 27.58  ? 94  ASP A CB  1 ? 
ATOM   709  C CG  . ASP A 1 94  ? -22.207 -9.347  8.691  1.00 30.99  ? 94  ASP A CG  1 ? 
ATOM   710  O OD1 . ASP A 1 94  ? -21.983 -10.284 7.901  1.00 38.17  ? 94  ASP A OD1 1 ? 
ATOM   711  O OD2 . ASP A 1 94  ? -23.339 -9.190  9.198  1.00 35.59  ? 94  ASP A OD2 1 ? 
ATOM   712  N N   . ALA A 1 95  ? -18.020 -7.479  9.808  1.00 22.26  ? 95  ALA A N   1 ? 
ATOM   713  C CA  . ALA A 1 95  ? -17.004 -6.443  9.835  1.00 25.83  ? 95  ALA A CA  1 ? 
ATOM   714  C C   . ALA A 1 95  ? -15.805 -6.845  8.995  1.00 28.24  ? 95  ALA A C   1 ? 
ATOM   715  O O   . ALA A 1 95  ? -15.234 -6.020  8.270  1.00 31.80  ? 95  ALA A O   1 ? 
ATOM   716  C CB  . ALA A 1 95  ? -16.598 -6.135  11.267 1.00 21.02  ? 95  ALA A CB  1 ? 
ATOM   717  N N   . MET A 1 96  ? -15.412 -8.115  9.059  1.00 28.82  ? 96  MET A N   1 ? 
ATOM   718  C CA  . MET A 1 96  ? -14.285 -8.559  8.248  1.00 26.21  ? 96  MET A CA  1 ? 
ATOM   719  C C   . MET A 1 96  ? -14.592 -8.363  6.773  1.00 31.97  ? 96  MET A C   1 ? 
ATOM   720  O O   . MET A 1 96  ? -13.782 -7.815  6.026  1.00 29.73  ? 96  MET A O   1 ? 
ATOM   721  C CB  . MET A 1 96  ? -13.969 -10.032 8.520  1.00 29.55  ? 96  MET A CB  1 ? 
ATOM   722  C CG  . MET A 1 96  ? -13.519 -10.366 9.946  1.00 32.95  ? 96  MET A CG  1 ? 
ATOM   723  S SD  . MET A 1 96  ? -13.164 -12.125 10.117 1.00 36.26  ? 96  MET A SD  1 ? 
ATOM   724  C CE  . MET A 1 96  ? -12.013 -12.328 8.746  1.00 27.57  ? 96  MET A CE  1 ? 
ATOM   725  N N   . LYS A 1 97  ? -15.762 -8.842  6.339  1.00 31.96  ? 97  LYS A N   1 ? 
ATOM   726  C CA  . LYS A 1 97  ? -16.196 -8.691  4.949  1.00 41.28  ? 97  LYS A CA  1 ? 
ATOM   727  C C   . LYS A 1 97  ? -16.139 -7.223  4.534  1.00 38.18  ? 97  LYS A C   1 ? 
ATOM   728  O O   . LYS A 1 97  ? -15.449 -6.859  3.573  1.00 31.27  ? 97  LYS A O   1 ? 
ATOM   729  C CB  . LYS A 1 97  ? -17.614 -9.291  4.794  1.00 45.44  ? 97  LYS A CB  1 ? 
ATOM   730  C CG  . LYS A 1 97  ? -18.069 -9.592  3.333  1.00 57.41  ? 97  LYS A CG  1 ? 
ATOM   731  C CD  . LYS A 1 97  ? -19.126 -8.567  2.854  1.00 85.67  ? 97  LYS A CD  1 ? 
ATOM   732  C CE  . LYS A 1 97  ? -19.252 -8.402  1.301  1.00 91.55  ? 97  LYS A CE  1 ? 
ATOM   733  N NZ  . LYS A 1 97  ? -18.171 -7.620  0.575  1.00 57.32  ? 97  LYS A NZ  1 ? 
ATOM   734  N N   . GLU A 1 98  ? -16.797 -6.349  5.307  1.00 33.59  ? 98  GLU A N   1 ? 
ATOM   735  C CA  . GLU A 1 98  ? -16.791 -4.925  4.979  1.00 41.12  ? 98  GLU A CA  1 ? 
ATOM   736  C C   . GLU A 1 98  ? -15.373 -4.339  4.934  1.00 38.54  ? 98  GLU A C   1 ? 
ATOM   737  O O   . GLU A 1 98  ? -15.099 -3.455  4.125  1.00 39.76  ? 98  GLU A O   1 ? 
ATOM   738  C CB  . GLU A 1 98  ? -17.648 -4.162  5.987  1.00 42.92  ? 98  GLU A CB  1 ? 
ATOM   739  C CG  . GLU A 1 98  ? -17.877 -2.692  5.633  1.00 68.34  ? 98  GLU A CG  1 ? 
ATOM   740  C CD  . GLU A 1 98  ? -18.483 -1.897  6.779  1.00 93.84  ? 98  GLU A CD  1 ? 
ATOM   741  O OE1 . GLU A 1 98  ? -18.687 -2.478  7.870  1.00 85.94  ? 98  GLU A OE1 1 ? 
ATOM   742  O OE2 . GLU A 1 98  ? -18.807 -0.709  6.566  1.00 104.41 ? 98  GLU A OE2 1 ? 
ATOM   743  N N   . ALA A 1 99  ? -14.465 -4.777  5.806  1.00 30.77  ? 99  ALA A N   1 ? 
ATOM   744  C CA  . ALA A 1 99  ? -13.107 -4.250  5.738  1.00 32.08  ? 99  ALA A CA  1 ? 
ATOM   745  C C   . ALA A 1 99  ? -12.240 -4.953  4.689  1.00 29.86  ? 99  ALA A C   1 ? 
ATOM   746  O O   . ALA A 1 99  ? -11.024 -4.760  4.682  1.00 35.50  ? 99  ALA A O   1 ? 
ATOM   747  C CB  . ALA A 1 99  ? -12.414 -4.348  7.100  1.00 39.50  ? 99  ALA A CB  1 ? 
ATOM   748  N N   . GLY A 1 100 ? -12.826 -5.766  3.818  1.00 32.16  ? 100 GLY A N   1 ? 
ATOM   749  C CA  . GLY A 1 100 ? -12.020 -6.428  2.806  1.00 37.81  ? 100 GLY A CA  1 ? 
ATOM   750  C C   . GLY A 1 100 ? -11.047 -7.461  3.325  1.00 40.42  ? 100 GLY A C   1 ? 
ATOM   751  O O   . GLY A 1 100 ? -10.067 -7.759  2.662  1.00 43.11  ? 100 GLY A O   1 ? 
ATOM   752  N N   . ILE A 1 101 ? -11.295 -8.053  4.484  1.00 37.24  ? 101 ILE A N   1 ? 
ATOM   753  C CA  . ILE A 1 101 ? -10.428 -9.108  4.975  1.00 31.51  ? 101 ILE A CA  1 ? 
ATOM   754  C C   . ILE A 1 101 ? -10.943 -10.428 4.409  1.00 35.47  ? 101 ILE A C   1 ? 
ATOM   755  O O   . ILE A 1 101 ? -11.845 -11.031 4.967  1.00 38.76  ? 101 ILE A O   1 ? 
ATOM   756  C CB  . ILE A 1 101 ? -10.379 -9.110  6.495  1.00 29.90  ? 101 ILE A CB  1 ? 
ATOM   757  C CG1 . ILE A 1 101 ? -9.734  -7.838  7.014  1.00 38.10  ? 101 ILE A CG1 1 ? 
ATOM   758  C CG2 . ILE A 1 101 ? -9.599  -10.272 6.931  1.00 49.35  ? 101 ILE A CG2 1 ? 
ATOM   759  C CD1 . ILE A 1 101 ? -10.137 -7.535  8.434  1.00 43.51  ? 101 ILE A CD1 1 ? 
ATOM   760  N N   . ASN A 1 102 ? -10.361 -10.895 3.305  1.00 35.65  ? 102 ASN A N   1 ? 
ATOM   761  C CA  . ASN A 1 102 ? -10.743 -12.190 2.745  1.00 38.71  ? 102 ASN A CA  1 ? 
ATOM   762  C C   . ASN A 1 102 ? -9.979  -13.273 3.488  1.00 39.16  ? 102 ASN A C   1 ? 
ATOM   763  O O   . ASN A 1 102 ? -8.950  -13.008 4.089  1.00 40.94  ? 102 ASN A O   1 ? 
ATOM   764  C CB  . ASN A 1 102 ? -10.422 -12.274 1.250  1.00 51.14  ? 102 ASN A CB  1 ? 
ATOM   765  C CG  . ASN A 1 102 ? -10.573 -10.949 0.553  1.00 71.53  ? 102 ASN A CG  1 ? 
ATOM   766  O OD1 . ASN A 1 102 ? -11.653 -10.363 0.552  1.00 72.76  ? 102 ASN A OD1 1 ? 
ATOM   767  N ND2 . ASN A 1 102 ? -9.478  -10.455 -0.030 1.00 86.53  ? 102 ASN A ND2 1 ? 
ATOM   768  N N   . VAL A 1 103 ? -10.448 -14.503 3.439  1.00 26.63  ? 103 VAL A N   1 ? 
ATOM   769  C CA  . VAL A 1 103 ? -9.702  -15.596 4.051  1.00 28.69  ? 103 VAL A CA  1 ? 
ATOM   770  C C   . VAL A 1 103 ? -9.637  -16.731 3.049  1.00 25.76  ? 103 VAL A C   1 ? 
ATOM   771  O O   . VAL A 1 103 ? -10.548 -16.913 2.228  1.00 24.15  ? 103 VAL A O   1 ? 
ATOM   772  C CB  . VAL A 1 103 ? -10.345 -16.078 5.367  1.00 29.13  ? 103 VAL A CB  1 ? 
ATOM   773  C CG1 . VAL A 1 103 ? -10.429 -14.981 6.403  1.00 31.83  ? 103 VAL A CG1 1 ? 
ATOM   774  C CG2 . VAL A 1 103 ? -11.700 -16.532 5.027  1.00 33.87  ? 103 VAL A CG2 1 ? 
ATOM   775  N N   . ASP A 1 104 ? -8.554  -17.495 3.120  1.00 28.30  ? 104 ASP A N   1 ? 
ATOM   776  C CA  . ASP A 1 104 ? -8.352  -18.592 2.172  1.00 27.12  ? 104 ASP A CA  1 ? 
ATOM   777  C C   . ASP A 1 104 ? -9.017  -19.882 2.657  1.00 25.53  ? 104 ASP A C   1 ? 
ATOM   778  O O   . ASP A 1 104 ? -9.585  -20.619 1.856  1.00 20.55  ? 104 ASP A O   1 ? 
ATOM   779  C CB  . ASP A 1 104 ? -6.858  -18.806 1.933  1.00 31.10  ? 104 ASP A CB  1 ? 
ATOM   780  C CG  . ASP A 1 104 ? -6.113  -17.500 1.557  1.00 33.46  ? 104 ASP A CG  1 ? 
ATOM   781  O OD1 . ASP A 1 104 ? -6.281  -17.027 0.426  1.00 40.52  ? 104 ASP A OD1 1 ? 
ATOM   782  O OD2 . ASP A 1 104 ? -5.359  -16.957 2.405  1.00 37.70  ? 104 ASP A OD2 1 ? 
ATOM   783  N N   . TYR A 1 105 ? -9.001  -20.148 3.967  1.00 23.74  ? 105 TYR A N   1 ? 
ATOM   784  C CA  . TYR A 1 105 ? -9.574  -21.357 4.537  1.00 19.01  ? 105 TYR A CA  1 ? 
ATOM   785  C C   . TYR A 1 105 ? -10.358 -21.070 5.815  1.00 20.09  ? 105 TYR A C   1 ? 
ATOM   786  O O   . TYR A 1 105 ? -9.894  -20.340 6.699  1.00 19.90  ? 105 TYR A O   1 ? 
ATOM   787  C CB  . TYR A 1 105 ? -8.485  -22.389 4.880  1.00 22.58  ? 105 TYR A CB  1 ? 
ATOM   788  C CG  . TYR A 1 105 ? -7.816  -23.043 3.689  1.00 21.57  ? 105 TYR A CG  1 ? 
ATOM   789  C CD1 . TYR A 1 105 ? -8.260  -24.239 3.187  1.00 22.65  ? 105 TYR A CD1 1 ? 
ATOM   790  C CD2 . TYR A 1 105 ? -6.721  -22.433 3.067  1.00 40.97  ? 105 TYR A CD2 1 ? 
ATOM   791  C CE1 . TYR A 1 105 ? -7.654  -24.836 2.089  1.00 35.01  ? 105 TYR A CE1 1 ? 
ATOM   792  C CE2 . TYR A 1 105 ? -6.098  -23.019 1.971  1.00 38.60  ? 105 TYR A CE2 1 ? 
ATOM   793  C CZ  . TYR A 1 105 ? -6.565  -24.220 1.486  1.00 43.99  ? 105 TYR A CZ  1 ? 
ATOM   794  O OH  . TYR A 1 105 ? -5.930  -24.786 0.391  1.00 57.33  ? 105 TYR A OH  1 ? 
ATOM   795  N N   . VAL A 1 106 ? -11.518 -21.698 5.924  1.00 14.37  ? 106 VAL A N   1 ? 
ATOM   796  C CA  . VAL A 1 106 ? -12.293 -21.763 7.166  1.00 17.71  ? 106 VAL A CA  1 ? 
ATOM   797  C C   . VAL A 1 106 ? -12.376 -23.234 7.548  1.00 20.52  ? 106 VAL A C   1 ? 
ATOM   798  O O   . VAL A 1 106 ? -12.821 -24.062 6.753  1.00 24.79  ? 106 VAL A O   1 ? 
ATOM   799  C CB  . VAL A 1 106 ? -13.698 -21.139 7.044  1.00 15.76  ? 106 VAL A CB  1 ? 
ATOM   800  C CG1 . VAL A 1 106 ? -14.418 -21.249 8.421  1.00 20.79  ? 106 VAL A CG1 1 ? 
ATOM   801  C CG2 . VAL A 1 106 ? -13.640 -19.674 6.466  1.00 14.40  ? 106 VAL A CG2 1 ? 
ATOM   802  N N   . LEU A 1 107 ? -11.950 -23.551 8.764  1.00 17.85  ? 107 LEU A N   1 ? 
ATOM   803  C CA  . LEU A 1 107 ? -11.781 -24.912 9.248  1.00 18.06  ? 107 LEU A CA  1 ? 
ATOM   804  C C   . LEU A 1 107 ? -12.609 -25.093 10.510 1.00 17.78  ? 107 LEU A C   1 ? 
ATOM   805  O O   . LEU A 1 107 ? -12.359 -24.436 11.512 1.00 20.71  ? 107 LEU A O   1 ? 
ATOM   806  C CB  . LEU A 1 107 ? -10.308 -25.205 9.504  1.00 18.34  ? 107 LEU A CB  1 ? 
ATOM   807  C CG  . LEU A 1 107 ? -9.413  -25.017 8.246  1.00 21.28  ? 107 LEU A CG  1 ? 
ATOM   808  C CD1 . LEU A 1 107 ? -7.969  -25.084 8.732  1.00 22.87  ? 107 LEU A CD1 1 ? 
ATOM   809  C CD2 . LEU A 1 107 ? -9.691  -26.033 7.147  1.00 24.11  ? 107 LEU A CD2 1 ? 
ATOM   810  N N   . GLU A 1 108 ? -13.604 -25.968 10.448 1.00 16.34  ? 108 GLU A N   1 ? 
ATOM   811  C CA  . GLU A 1 108 ? -14.543 -26.199 11.548 1.00 23.87  ? 108 GLU A CA  1 ? 
ATOM   812  C C   . GLU A 1 108 ? -14.144 -27.446 12.339 1.00 25.29  ? 108 GLU A C   1 ? 
ATOM   813  O O   . GLU A 1 108 ? -14.057 -28.537 11.783 1.00 26.16  ? 108 GLU A O   1 ? 
ATOM   814  C CB  . GLU A 1 108 ? -15.972 -26.362 11.010 1.00 20.13  ? 108 GLU A CB  1 ? 
ATOM   815  C CG  . GLU A 1 108 ? -17.123 -26.615 12.049 1.00 31.86  ? 108 GLU A CG  1 ? 
ATOM   816  C CD  . GLU A 1 108 ? -18.297 -27.460 11.482 1.00 49.87  ? 108 GLU A CD  1 ? 
ATOM   817  O OE1 . GLU A 1 108 ? -18.512 -27.472 10.238 1.00 42.44  ? 108 GLU A OE1 1 ? 
ATOM   818  O OE2 . GLU A 1 108 ? -19.006 -28.131 12.279 1.00 53.10  ? 108 GLU A OE2 1 ? 
ATOM   819  N N   . PHE A 1 109 ? -13.964 -27.285 13.643 1.00 22.50  ? 109 PHE A N   1 ? 
ATOM   820  C CA  . PHE A 1 109 ? -13.684 -28.399 14.547 1.00 21.91  ? 109 PHE A CA  1 ? 
ATOM   821  C C   . PHE A 1 109 ? -15.020 -28.856 15.137 1.00 32.90  ? 109 PHE A C   1 ? 
ATOM   822  O O   . PHE A 1 109 ? -15.592 -28.155 15.977 1.00 29.62  ? 109 PHE A O   1 ? 
ATOM   823  C CB  . PHE A 1 109 ? -12.733 -27.972 15.662 1.00 26.60  ? 109 PHE A CB  1 ? 
ATOM   824  C CG  . PHE A 1 109 ? -11.356 -27.610 15.177 1.00 28.91  ? 109 PHE A CG  1 ? 
ATOM   825  C CD1 . PHE A 1 109 ? -11.178 -26.639 14.213 1.00 26.41  ? 109 PHE A CD1 1 ? 
ATOM   826  C CD2 . PHE A 1 109 ? -10.238 -28.241 15.689 1.00 30.05  ? 109 PHE A CD2 1 ? 
ATOM   827  C CE1 . PHE A 1 109 ? -9.924  -26.305 13.744 1.00 25.83  ? 109 PHE A CE1 1 ? 
ATOM   828  C CE2 . PHE A 1 109 ? -8.977  -27.897 15.229 1.00 30.56  ? 109 PHE A CE2 1 ? 
ATOM   829  C CZ  . PHE A 1 109 ? -8.822  -26.931 14.255 1.00 27.94  ? 109 PHE A CZ  1 ? 
ATOM   830  N N   . ASP A 1 110 ? -15.521 -30.030 14.731 1.00 28.74  ? 110 ASP A N   1 ? 
ATOM   831  C CA  . ASP A 1 110 ? -16.746 -30.561 15.325 1.00 24.33  ? 110 ASP A CA  1 ? 
ATOM   832  C C   . ASP A 1 110 ? -16.411 -31.414 16.542 1.00 32.71  ? 110 ASP A C   1 ? 
ATOM   833  O O   . ASP A 1 110 ? -15.754 -32.443 16.395 1.00 24.28  ? 110 ASP A O   1 ? 
ATOM   834  C CB  . ASP A 1 110 ? -17.523 -31.394 14.315 1.00 34.77  ? 110 ASP A CB  1 ? 
ATOM   835  C CG  . ASP A 1 110 ? -18.825 -31.975 14.892 1.00 58.39  ? 110 ASP A CG  1 ? 
ATOM   836  O OD1 . ASP A 1 110 ? -19.712 -31.189 15.309 1.00 49.79  ? 110 ASP A OD1 1 ? 
ATOM   837  O OD2 . ASP A 1 110 ? -18.972 -33.221 14.863 1.00 65.02  ? 110 ASP A OD2 1 ? 
ATOM   838  N N   . VAL A 1 111 ? -16.905 -31.031 17.727 1.00 26.46  ? 111 VAL A N   1 ? 
ATOM   839  C CA  . VAL A 1 111 ? -16.725 -31.849 18.940 1.00 26.02  ? 111 VAL A CA  1 ? 
ATOM   840  C C   . VAL A 1 111 ? -18.051 -31.835 19.704 1.00 37.25  ? 111 VAL A C   1 ? 
ATOM   841  O O   . VAL A 1 111 ? -18.631 -30.755 19.858 1.00 27.58  ? 111 VAL A O   1 ? 
ATOM   842  C CB  . VAL A 1 111 ? -15.577 -31.325 19.830 1.00 26.35  ? 111 VAL A CB  1 ? 
ATOM   843  C CG1 . VAL A 1 111 ? -15.374 -32.185 21.081 1.00 25.90  ? 111 VAL A CG1 1 ? 
ATOM   844  C CG2 . VAL A 1 111 ? -14.239 -31.269 19.104 1.00 22.30  ? 111 VAL A CG2 1 ? 
ATOM   845  N N   . PRO A 1 112 ? -18.591 -32.972 20.182 1.00 31.32  ? 112 PRO A N   1 ? 
ATOM   846  C CA  . PRO A 1 112 ? -19.858 -32.920 20.921 1.00 32.51  ? 112 PRO A CA  1 ? 
ATOM   847  C C   . PRO A 1 112 ? -19.791 -32.080 22.185 1.00 28.33  ? 112 PRO A C   1 ? 
ATOM   848  O O   . PRO A 1 112 ? -18.747 -31.964 22.832 1.00 27.04  ? 112 PRO A O   1 ? 
ATOM   849  C CB  . PRO A 1 112 ? -20.125 -34.390 21.270 1.00 31.69  ? 112 PRO A CB  1 ? 
ATOM   850  C CG  . PRO A 1 112 ? -19.501 -35.135 20.183 1.00 38.24  ? 112 PRO A CG  1 ? 
ATOM   851  C CD  . PRO A 1 112 ? -18.264 -34.352 19.785 1.00 35.97  ? 112 PRO A CD  1 ? 
ATOM   852  N N   . ASP A 1 113 ? -20.952 -31.552 22.575 1.00 27.66  ? 113 ASP A N   1 ? 
ATOM   853  C CA  . ASP A 1 113 ? -21.020 -30.716 23.769 1.00 33.93  ? 113 ASP A CA  1 ? 
ATOM   854  C C   . ASP A 1 113 ? -20.543 -31.458 25.013 1.00 35.06  ? 113 ASP A C   1 ? 
ATOM   855  O O   . ASP A 1 113 ? -19.904 -30.855 25.887 1.00 30.23  ? 113 ASP A O   1 ? 
ATOM   856  C CB  . ASP A 1 113 ? -22.450 -30.187 23.974 1.00 48.75  ? 113 ASP A CB  1 ? 
ATOM   857  C CG  . ASP A 1 113 ? -22.679 -28.808 23.331 1.00 57.34  ? 113 ASP A CG  1 ? 
ATOM   858  O OD1 . ASP A 1 113 ? -22.013 -28.513 22.314 1.00 61.08  ? 113 ASP A OD1 1 ? 
ATOM   859  O OD2 . ASP A 1 113 ? -23.519 -28.012 23.840 1.00 58.39  ? 113 ASP A OD2 1 ? 
ATOM   860  N N   . GLU A 1 114 ? -20.855 -32.759 25.128 1.00 39.34  ? 114 GLU A N   1 ? 
ATOM   861  C CA  . GLU A 1 114 ? -20.524 -33.499 26.354 1.00 30.83  ? 114 GLU A CA  1 ? 
ATOM   862  C C   . GLU A 1 114 ? -19.018 -33.672 26.501 1.00 29.17  ? 114 GLU A C   1 ? 
ATOM   863  O O   . GLU A 1 114 ? -18.495 -33.766 27.620 1.00 37.61  ? 114 GLU A O   1 ? 
ATOM   864  C CB  . GLU A 1 114 ? -21.224 -34.854 26.333 1.00 31.91  ? 114 GLU A CB  1 ? 
ATOM   865  C CG  . GLU A 1 114 ? -22.769 -34.774 26.317 1.00 46.16  ? 114 GLU A CG  1 ? 
ATOM   866  C CD  . GLU A 1 114 ? -23.409 -34.610 24.905 1.00 58.43  ? 114 GLU A CD  1 ? 
ATOM   867  O OE1 . GLU A 1 114 ? -22.850 -33.924 24.027 1.00 46.35  ? 114 GLU A OE1 1 ? 
ATOM   868  O OE2 . GLU A 1 114 ? -24.494 -35.183 24.667 1.00 58.08  ? 114 GLU A OE2 1 ? 
ATOM   869  N N   . LEU A 1 115 ? -18.299 -33.675 25.379 1.00 27.83  ? 115 LEU A N   1 ? 
ATOM   870  C CA  . LEU A 1 115 ? -16.850 -33.803 25.438 1.00 30.46  ? 115 LEU A CA  1 ? 
ATOM   871  C C   . LEU A 1 115 ? -16.165 -32.505 25.841 1.00 36.11  ? 115 LEU A C   1 ? 
ATOM   872  O O   . LEU A 1 115 ? -15.142 -32.543 26.541 1.00 34.09  ? 115 LEU A O   1 ? 
ATOM   873  C CB  . LEU A 1 115 ? -16.306 -34.292 24.085 1.00 31.27  ? 115 LEU A CB  1 ? 
ATOM   874  C CG  . LEU A 1 115 ? -16.768 -35.667 23.577 1.00 36.33  ? 115 LEU A CG  1 ? 
ATOM   875  C CD1 . LEU A 1 115 ? -15.661 -36.337 22.732 1.00 36.70  ? 115 LEU A CD1 1 ? 
ATOM   876  C CD2 . LEU A 1 115 ? -17.238 -36.551 24.740 1.00 30.93  ? 115 LEU A CD2 1 ? 
ATOM   877  N N   . ILE A 1 116 ? -16.720 -31.362 25.430 1.00 41.84  ? 116 ILE A N   1 ? 
ATOM   878  C CA  . ILE A 1 116 ? -16.138 -30.063 25.766 1.00 38.45  ? 116 ILE A CA  1 ? 
ATOM   879  C C   . ILE A 1 116 ? -16.002 -29.901 27.270 1.00 38.20  ? 116 ILE A C   1 ? 
ATOM   880  O O   . ILE A 1 116 ? -14.952 -29.478 27.783 1.00 30.55  ? 116 ILE A O   1 ? 
ATOM   881  C CB  . ILE A 1 116 ? -17.002 -28.924 25.204 1.00 33.48  ? 116 ILE A CB  1 ? 
ATOM   882  C CG1 . ILE A 1 116 ? -17.159 -29.055 23.691 1.00 36.44  ? 116 ILE A CG1 1 ? 
ATOM   883  C CG2 . ILE A 1 116 ? -16.428 -27.608 25.669 1.00 39.60  ? 116 ILE A CG2 1 ? 
ATOM   884  C CD1 . ILE A 1 116 ? -15.929 -28.763 22.900 1.00 37.75  ? 116 ILE A CD1 1 ? 
ATOM   885  N N   . VAL A 1 117 ? -17.100 -30.131 27.988 1.00 41.24  ? 117 VAL A N   1 ? 
ATOM   886  C CA  . VAL A 1 117 ? -17.100 -29.904 29.425 1.00 32.77  ? 117 VAL A CA  1 ? 
ATOM   887  C C   . VAL A 1 117 ? -15.932 -30.633 30.063 1.00 40.87  ? 117 VAL A C   1 ? 
ATOM   888  O O   . VAL A 1 117 ? -15.155 -30.050 30.827 1.00 37.70  ? 117 VAL A O   1 ? 
ATOM   889  C CB  . VAL A 1 117 ? -18.438 -30.346 30.046 1.00 54.20  ? 117 VAL A CB  1 ? 
ATOM   890  C CG1 . VAL A 1 117 ? -18.534 -29.786 31.462 1.00 53.01  ? 117 VAL A CG1 1 ? 
ATOM   891  C CG2 . VAL A 1 117 ? -19.627 -29.899 29.162 1.00 49.34  ? 117 VAL A CG2 1 ? 
ATOM   892  N N   . ASP A 1 118 ? -15.777 -31.926 29.744 1.00 45.82  ? 118 ASP A N   1 ? 
ATOM   893  C CA  . ASP A 1 118 ? -14.714 -32.674 30.402 1.00 48.53  ? 118 ASP A CA  1 ? 
ATOM   894  C C   . ASP A 1 118 ? -13.348 -32.225 29.923 1.00 46.34  ? 118 ASP A C   1 ? 
ATOM   895  O O   . ASP A 1 118 ? -12.383 -32.266 30.695 1.00 44.32  ? 118 ASP A O   1 ? 
ATOM   896  C CB  . ASP A 1 118 ? -14.877 -34.163 30.187 1.00 60.15  ? 118 ASP A CB  1 ? 
ATOM   897  C CG  . ASP A 1 118 ? -15.370 -34.855 31.425 1.00 74.61  ? 118 ASP A CG  1 ? 
ATOM   898  O OD1 . ASP A 1 118 ? -15.069 -34.372 32.537 1.00 58.69  ? 118 ASP A OD1 1 ? 
ATOM   899  O OD2 . ASP A 1 118 ? -16.053 -35.887 31.286 1.00 82.77  ? 118 ASP A OD2 1 ? 
ATOM   900  N N   . ARG A 1 119 ? -13.240 -31.770 28.674 1.00 36.54  ? 119 ARG A N   1 ? 
ATOM   901  C CA  . ARG A 1 119 ? -11.935 -31.323 28.206 1.00 36.52  ? 119 ARG A CA  1 ? 
ATOM   902  C C   . ARG A 1 119 ? -11.499 -30.062 28.929 1.00 36.75  ? 119 ARG A C   1 ? 
ATOM   903  O O   . ARG A 1 119 ? -10.321 -29.910 29.268 1.00 44.77  ? 119 ARG A O   1 ? 
ATOM   904  C CB  . ARG A 1 119 ? -11.962 -31.079 26.705 1.00 36.50  ? 119 ARG A CB  1 ? 
ATOM   905  C CG  . ARG A 1 119 ? -11.637 -32.278 25.875 1.00 35.82  ? 119 ARG A CG  1 ? 
ATOM   906  C CD  . ARG A 1 119 ? -11.597 -31.890 24.448 1.00 31.05  ? 119 ARG A CD  1 ? 
ATOM   907  N NE  . ARG A 1 119 ? -11.771 -33.069 23.628 1.00 30.59  ? 119 ARG A NE  1 ? 
ATOM   908  C CZ  . ARG A 1 119 ? -11.659 -33.064 22.308 1.00 28.44  ? 119 ARG A CZ  1 ? 
ATOM   909  N NH1 . ARG A 1 119 ? -11.377 -31.938 21.675 1.00 30.51  ? 119 ARG A NH1 1 ? 
ATOM   910  N NH2 . ARG A 1 119 ? -11.837 -34.181 21.625 1.00 30.40  ? 119 ARG A NH2 1 ? 
ATOM   911  N N   . ILE A 1 120 ? -12.431 -29.146 29.167 1.00 34.63  ? 120 ILE A N   1 ? 
ATOM   912  C CA  . ILE A 1 120 ? -12.063 -27.867 29.763 1.00 41.04  ? 120 ILE A CA  1 ? 
ATOM   913  C C   . ILE A 1 120 ? -11.830 -28.013 31.258 1.00 43.93  ? 120 ILE A C   1 ? 
ATOM   914  O O   . ILE A 1 120 ? -10.976 -27.331 31.817 1.00 52.59  ? 120 ILE A O   1 ? 
ATOM   915  C CB  . ILE A 1 120 ? -13.134 -26.808 29.449 1.00 43.54  ? 120 ILE A CB  1 ? 
ATOM   916  C CG1 . ILE A 1 120 ? -13.051 -26.422 27.968 1.00 38.80  ? 120 ILE A CG1 1 ? 
ATOM   917  C CG2 . ILE A 1 120 ? -12.969 -25.539 30.289 1.00 39.47  ? 120 ILE A CG2 1 ? 
ATOM   918  C CD1 . ILE A 1 120 ? -14.163 -25.524 27.525 1.00 38.40  ? 120 ILE A CD1 1 ? 
ATOM   919  N N   . LEU A 1 121 ? -12.548 -28.910 31.926 1.00 46.12  ? 121 LEU A N   1 ? 
ATOM   920  C CA  . LEU A 1 121 ? -12.242 -29.186 33.329 1.00 52.80  ? 121 LEU A CA  1 ? 
ATOM   921  C C   . LEU A 1 121 ? -10.804 -29.641 33.489 1.00 57.34  ? 121 LEU A C   1 ? 
ATOM   922  O O   . LEU A 1 121 ? -10.075 -29.157 34.357 1.00 69.53  ? 121 LEU A O   1 ? 
ATOM   923  C CB  . LEU A 1 121 ? -13.172 -30.265 33.876 1.00 47.41  ? 121 LEU A CB  1 ? 
ATOM   924  C CG  . LEU A 1 121 ? -14.640 -29.861 33.913 1.00 55.59  ? 121 LEU A CG  1 ? 
ATOM   925  C CD1 . LEU A 1 121 ? -15.417 -30.762 34.839 1.00 75.82  ? 121 LEU A CD1 1 ? 
ATOM   926  C CD2 . LEU A 1 121 ? -14.825 -28.406 34.322 1.00 65.29  ? 121 LEU A CD2 1 ? 
ATOM   927  N N   . LYS A 1 122 ? -10.430 -30.637 32.700 1.00 56.36  ? 122 LYS A N   1 ? 
ATOM   928  C CA  . LYS A 1 122 ? -9.093  -31.260 32.776 1.00 60.35  ? 122 LYS A CA  1 ? 
ATOM   929  C C   . LYS A 1 122 ? -8.027  -30.216 32.458 1.00 62.98  ? 122 LYS A C   1 ? 
ATOM   930  O O   . LYS A 1 122 ? -6.902  -30.457 32.808 1.00 77.93  ? 122 LYS A O   1 ? 
ATOM   931  C CB  . LYS A 1 122 ? -9.029  -32.511 31.897 1.00 62.67  ? 122 LYS A CB  1 ? 
ATOM   932  C CG  . LYS A 1 122 ? -9.519  -33.774 32.587 1.00 69.09  ? 122 LYS A CG  1 ? 
ATOM   933  C CD  . LYS A 1 122 ? -10.108 -34.810 31.667 1.00 79.97  ? 122 LYS A CD  1 ? 
ATOM   934  C CE  . LYS A 1 122 ? -11.250 -35.588 32.290 1.00 68.52  ? 122 LYS A CE  1 ? 
ATOM   935  N NZ  . LYS A 1 122 ? -11.038 -37.053 32.179 1.00 63.97  ? 122 LYS A NZ  1 ? 
ATOM   936  N N   . ARG A 1 123 ? -8.333  -29.113 31.789 1.00 60.81  ? 123 ARG A N   1 ? 
ATOM   937  C CA  . ARG A 1 123 ? -7.299  -28.080 31.560 1.00 72.61  ? 123 ARG A CA  1 ? 
ATOM   938  C C   . ARG A 1 123 ? -7.470  -26.862 32.475 1.00 76.42  ? 123 ARG A C   1 ? 
ATOM   939  O O   . ARG A 1 123 ? -6.514  -26.118 32.644 1.00 83.52  ? 123 ARG A O   1 ? 
ATOM   940  C CB  . ARG A 1 123 ? -7.350  -27.631 30.116 1.00 64.01  ? 123 ARG A CB  1 ? 
ATOM   941  C CG  . ARG A 1 123 ? -6.152  -26.781 29.734 1.00 71.68  ? 123 ARG A CG  1 ? 
ATOM   942  C CD  . ARG A 1 123 ? -6.525  -25.675 28.795 1.00 69.28  ? 123 ARG A CD  1 ? 
ATOM   943  N NE  . ARG A 1 123 ? -7.781  -25.057 29.151 1.00 75.23  ? 123 ARG A NE  1 ? 
ATOM   944  C CZ  . ARG A 1 123 ? -8.382  -24.158 28.409 1.00 78.59  ? 123 ARG A CZ  1 ? 
ATOM   945  N NH1 . ARG A 1 123 ? -9.546  -23.652 28.762 1.00 64.62  ? 123 ARG A NH1 1 ? 
ATOM   946  N NH2 . ARG A 1 123 ? -7.840  -23.797 27.263 1.00 89.55  ? 123 ARG A NH2 1 ? 
ATOM   947  N N   . GLY A 1 124 ? -8.637  -26.699 33.077 1.00 72.28  ? 124 GLY A N   1 ? 
ATOM   948  C CA  . GLY A 1 124 ? -8.964  -25.612 34.013 1.00 77.95  ? 124 GLY A CA  1 ? 
ATOM   949  C C   . GLY A 1 124 ? -8.269  -25.812 35.346 1.00 93.71  ? 124 GLY A C   1 ? 
ATOM   950  O O   . GLY A 1 124 ? -8.038  -24.810 36.040 1.00 103.19 ? 124 GLY A O   1 ? 
ATOM   951  N N   . GLU A 1 125 ? -7.884  -27.054 35.671 1.00 88.47  ? 125 GLU A N   1 ? 
ATOM   952  C CA  . GLU A 1 125 ? -7.176  -27.420 36.923 1.00 92.22  ? 125 GLU A CA  1 ? 
ATOM   953  C C   . GLU A 1 125 ? -5.723  -26.921 36.920 1.00 102.43 ? 125 GLU A C   1 ? 
ATOM   954  O O   . GLU A 1 125 ? -5.140  -26.927 37.994 1.00 111.40 ? 125 GLU A O   1 ? 
ATOM   955  C CB  . GLU A 1 125 ? -7.206  -28.930 37.158 1.00 85.45  ? 125 GLU A CB  1 ? 
ATOM   956  C CG  . GLU A 1 125 ? -6.868  -29.728 35.926 1.00 82.70  ? 125 GLU A CG  1 ? 
ATOM   957  C CD  . GLU A 1 125 ? -6.365  -31.142 36.143 1.00 92.17  ? 125 GLU A CD  1 ? 
ATOM   958  O OE1 . GLU A 1 125 ? -5.315  -31.481 35.583 1.00 98.59  ? 125 GLU A OE1 1 ? 
ATOM   959  O OE2 . GLU A 1 125 ? -7.042  -31.909 36.836 1.00 85.48  ? 125 GLU A OE2 1 ? 
ATOM   960  N N   . THR A 1 126 ? -5.133  -26.499 35.799 1.00 96.17  ? 126 THR A N   1 ? 
ATOM   961  C CA  . THR A 1 126 ? -3.761  -26.004 35.836 1.00 90.60  ? 126 THR A CA  1 ? 
ATOM   962  C C   . THR A 1 126 ? -3.584  -24.583 35.320 1.00 93.25  ? 126 THR A C   1 ? 
ATOM   963  O O   . THR A 1 126 ? -2.679  -23.885 35.790 1.00 95.44  ? 126 THR A O   1 ? 
ATOM   964  C CB  . THR A 1 126 ? -2.843  -26.928 35.021 1.00 95.04  ? 126 THR A CB  1 ? 
ATOM   965  O OG1 . THR A 1 126 ? -3.138  -26.774 33.625 1.00 98.50  ? 126 THR A OG1 1 ? 
ATOM   966  C CG2 . THR A 1 126 ? -3.034  -28.375 35.443 1.00 90.98  ? 126 THR A CG2 1 ? 
ATOM   967  N N   . SER A 1 127 ? -4.393  -24.146 34.351 1.00 89.25  ? 127 SER A N   1 ? 
ATOM   968  C CA  . SER A 1 127 ? -4.329  -22.784 33.831 1.00 88.14  ? 127 SER A CA  1 ? 
ATOM   969  C C   . SER A 1 127 ? -5.153  -21.805 34.657 1.00 81.01  ? 127 SER A C   1 ? 
ATOM   970  O O   . SER A 1 127 ? -5.087  -20.595 34.409 1.00 77.39  ? 127 SER A O   1 ? 
ATOM   971  C CB  . SER A 1 127 ? -4.823  -22.727 32.387 1.00 96.40  ? 127 SER A CB  1 ? 
ATOM   972  O OG  . SER A 1 127 ? -6.231  -22.519 32.354 1.00 83.15  ? 127 SER A OG  1 ? 
ATOM   973  N N   . GLY A 1 128 ? -5.959  -22.310 35.589 1.00 79.04  ? 128 GLY A N   1 ? 
ATOM   974  C CA  . GLY A 1 128 ? -6.638  -21.472 36.561 1.00 74.66  ? 128 GLY A CA  1 ? 
ATOM   975  C C   . GLY A 1 128 ? -7.373  -20.280 35.991 1.00 73.88  ? 128 GLY A C   1 ? 
ATOM   976  O O   . GLY A 1 128 ? -7.334  -19.197 36.578 1.00 64.78  ? 128 GLY A O   1 ? 
ATOM   977  N N   . ARG A 1 129 ? -8.038  -20.442 34.858 1.00 77.78  ? 129 ARG A N   1 ? 
ATOM   978  C CA  . ARG A 1 129 ? -8.922  -19.407 34.349 1.00 61.48  ? 129 ARG A CA  1 ? 
ATOM   979  C C   . ARG A 1 129 ? -10.284 -19.576 34.997 1.00 49.81  ? 129 ARG A C   1 ? 
ATOM   980  O O   . ARG A 1 129 ? -10.773 -20.697 35.143 1.00 49.58  ? 129 ARG A O   1 ? 
ATOM   981  C CB  . ARG A 1 129 ? -9.047  -19.482 32.834 1.00 59.66  ? 129 ARG A CB  1 ? 
ATOM   982  C CG  . ARG A 1 129 ? -7.913  -18.821 32.092 1.00 64.81  ? 129 ARG A CG  1 ? 
ATOM   983  C CD  . ARG A 1 129 ? -7.907  -19.247 30.621 1.00 60.94  ? 129 ARG A CD  1 ? 
ATOM   984  N NE  . ARG A 1 129 ? -9.248  -19.306 30.028 1.00 62.50  ? 129 ARG A NE  1 ? 
ATOM   985  C CZ  . ARG A 1 129 ? -9.495  -19.598 28.751 1.00 56.75  ? 129 ARG A CZ  1 ? 
ATOM   986  N NH1 . ARG A 1 129 ? -8.489  -19.849 27.925 1.00 50.53  ? 129 ARG A NH1 1 ? 
ATOM   987  N NH2 . ARG A 1 129 ? -10.742 -19.632 28.288 1.00 43.86  ? 129 ARG A NH2 1 ? 
ATOM   988  N N   . VAL A 1 130 ? -10.898 -18.454 35.382 1.00 48.38  ? 130 VAL A N   1 ? 
ATOM   989  C CA  . VAL A 1 130 ? -12.207 -18.523 36.020 1.00 43.32  ? 130 VAL A CA  1 ? 
ATOM   990  C C   . VAL A 1 130 ? -13.283 -18.993 35.054 1.00 48.51  ? 130 VAL A C   1 ? 
ATOM   991  O O   . VAL A 1 130 ? -14.282 -19.592 35.477 1.00 44.04  ? 130 VAL A O   1 ? 
ATOM   992  C CB  . VAL A 1 130 ? -12.600 -17.161 36.614 1.00 45.29  ? 130 VAL A CB  1 ? 
ATOM   993  C CG1 . VAL A 1 130 ? -14.093 -17.192 37.018 1.00 38.60  ? 130 VAL A CG1 1 ? 
ATOM   994  C CG2 . VAL A 1 130 ? -11.687 -16.811 37.769 1.00 48.59  ? 130 VAL A CG2 1 ? 
ATOM   995  N N   . ASP A 1 131 ? -13.137 -18.683 33.761 1.00 48.18  ? 131 ASP A N   1 ? 
ATOM   996  C CA  . ASP A 1 131 ? -14.081 -19.122 32.737 1.00 53.38  ? 131 ASP A CA  1 ? 
ATOM   997  C C   . ASP A 1 131 ? -13.918 -20.600 32.364 1.00 45.76  ? 131 ASP A C   1 ? 
ATOM   998  O O   . ASP A 1 131 ? -14.646 -21.080 31.485 1.00 44.94  ? 131 ASP A O   1 ? 
ATOM   999  C CB  . ASP A 1 131 ? -13.960 -18.229 31.476 1.00 48.74  ? 131 ASP A CB  1 ? 
ATOM   1000 C CG  . ASP A 1 131 ? -12.531 -18.115 30.949 1.00 57.57  ? 131 ASP A CG  1 ? 
ATOM   1001 O OD1 . ASP A 1 131 ? -12.216 -17.140 30.218 1.00 56.94  ? 131 ASP A OD1 1 ? 
ATOM   1002 O OD2 . ASP A 1 131 ? -11.716 -19.000 31.275 1.00 65.37  ? 131 ASP A OD2 1 ? 
ATOM   1003 N N   . ASP A 1 132 ? -13.021 -21.341 33.035 1.00 37.20  ? 132 ASP A N   1 ? 
ATOM   1004 C CA  . ASP A 1 132 ? -12.919 -22.799 32.910 1.00 48.56  ? 132 ASP A CA  1 ? 
ATOM   1005 C C   . ASP A 1 132 ? -13.644 -23.553 34.037 1.00 50.36  ? 132 ASP A C   1 ? 
ATOM   1006 O O   . ASP A 1 132 ? -13.680 -24.785 34.023 1.00 48.96  ? 132 ASP A O   1 ? 
ATOM   1007 C CB  . ASP A 1 132 ? -11.443 -23.236 32.878 1.00 57.76  ? 132 ASP A CB  1 ? 
ATOM   1008 C CG  . ASP A 1 132 ? -10.765 -23.020 31.510 1.00 68.02  ? 132 ASP A CG  1 ? 
ATOM   1009 O OD1 . ASP A 1 132 ? -11.344 -22.371 30.614 1.00 58.53  ? 132 ASP A OD1 1 ? 
ATOM   1010 O OD2 . ASP A 1 132 ? -9.618  -23.490 31.343 1.00 77.82  ? 132 ASP A OD2 1 ? 
ATOM   1011 N N   . ASN A 1 133 ? -14.218 -22.855 35.012 1.00 53.89  ? 133 ASN A N   1 ? 
ATOM   1012 C CA  . ASN A 1 133 ? -15.113 -23.497 35.965 1.00 46.69  ? 133 ASN A CA  1 ? 
ATOM   1013 C C   . ASN A 1 133 ? -16.249 -24.207 35.234 1.00 54.65  ? 133 ASN A C   1 ? 
ATOM   1014 O O   . ASN A 1 133 ? -16.623 -23.852 34.119 1.00 60.10  ? 133 ASN A O   1 ? 
ATOM   1015 C CB  . ASN A 1 133 ? -15.734 -22.472 36.900 1.00 47.98  ? 133 ASN A CB  1 ? 
ATOM   1016 C CG  . ASN A 1 133 ? -14.758 -21.944 37.898 1.00 56.62  ? 133 ASN A CG  1 ? 
ATOM   1017 O OD1 . ASN A 1 133 ? -13.607 -22.368 37.937 1.00 65.64  ? 133 ASN A OD1 1 ? 
ATOM   1018 N ND2 . ASN A 1 133 ? -15.200 -20.991 38.710 1.00 50.91  ? 133 ASN A ND2 1 ? 
ATOM   1019 N N   . GLU A 1 134 ? -16.864 -25.167 35.915 1.00 52.01  ? 134 GLU A N   1 ? 
ATOM   1020 C CA  . GLU A 1 134 ? -17.854 -26.018 35.264 1.00 59.15  ? 134 GLU A CA  1 ? 
ATOM   1021 C C   . GLU A 1 134 ? -19.089 -25.223 34.869 1.00 49.90  ? 134 GLU A C   1 ? 
ATOM   1022 O O   . GLU A 1 134 ? -19.601 -25.357 33.756 1.00 52.19  ? 134 GLU A O   1 ? 
ATOM   1023 C CB  . GLU A 1 134 ? -18.238 -27.167 36.196 1.00 74.75  ? 134 GLU A CB  1 ? 
ATOM   1024 C CG  . GLU A 1 134 ? -19.210 -28.187 35.612 1.00 75.08  ? 134 GLU A CG  1 ? 
ATOM   1025 C CD  . GLU A 1 134 ? -19.208 -29.500 36.408 1.00 76.52  ? 134 GLU A CD  1 ? 
ATOM   1026 O OE1 . GLU A 1 134 ? -20.239 -29.811 37.033 1.00 84.44  ? 134 GLU A OE1 1 ? 
ATOM   1027 O OE2 . GLU A 1 134 ? -18.172 -30.209 36.438 1.00 78.48  ? 134 GLU A OE2 1 ? 
ATOM   1028 N N   . GLU A 1 135 ? -19.609 -24.397 35.762 1.00 55.21  ? 135 GLU A N   1 ? 
ATOM   1029 C CA  . GLU A 1 135 ? -20.867 -23.760 35.384 1.00 61.11  ? 135 GLU A CA  1 ? 
ATOM   1030 C C   . GLU A 1 135 ? -20.641 -22.666 34.362 1.00 49.25  ? 135 GLU A C   1 ? 
ATOM   1031 O O   . GLU A 1 135 ? -21.453 -22.481 33.453 1.00 44.59  ? 135 GLU A O   1 ? 
ATOM   1032 C CB  . GLU A 1 135 ? -21.599 -23.229 36.609 1.00 55.81  ? 135 GLU A CB  1 ? 
ATOM   1033 C CG  . GLU A 1 135 ? -22.557 -24.280 37.167 1.00 85.75  ? 135 GLU A CG  1 ? 
ATOM   1034 C CD  . GLU A 1 135 ? -21.852 -25.397 37.946 1.00 97.18  ? 135 GLU A CD  1 ? 
ATOM   1035 O OE1 . GLU A 1 135 ? -21.648 -26.506 37.392 1.00 87.00  ? 135 GLU A OE1 1 ? 
ATOM   1036 O OE2 . GLU A 1 135 ? -21.519 -25.168 39.127 1.00 90.14  ? 135 GLU A OE2 1 ? 
ATOM   1037 N N   . THR A 1 136 ? -19.527 -21.966 34.455 1.00 43.58  ? 136 THR A N   1 ? 
ATOM   1038 C CA  . THR A 1 136 ? -19.245 -20.973 33.435 1.00 45.55  ? 136 THR A CA  1 ? 
ATOM   1039 C C   . THR A 1 136 ? -19.143 -21.638 32.071 1.00 52.92  ? 136 THR A C   1 ? 
ATOM   1040 O O   . THR A 1 136 ? -19.750 -21.171 31.097 1.00 40.25  ? 136 THR A O   1 ? 
ATOM   1041 C CB  . THR A 1 136 ? -17.985 -20.210 33.810 1.00 46.49  ? 136 THR A CB  1 ? 
ATOM   1042 O OG1 . THR A 1 136 ? -18.106 -19.821 35.188 1.00 53.07  ? 136 THR A OG1 1 ? 
ATOM   1043 C CG2 . THR A 1 136 ? -17.820 -18.991 32.952 1.00 38.23  ? 136 THR A CG2 1 ? 
ATOM   1044 N N   . VAL A 1 137 ? -18.462 -22.784 32.007 1.00 44.59  ? 137 VAL A N   1 ? 
ATOM   1045 C CA  . VAL A 1 137 ? -18.266 -23.461 30.732 1.00 40.06  ? 137 VAL A CA  1 ? 
ATOM   1046 C C   . VAL A 1 137 ? -19.609 -23.800 30.094 1.00 43.24  ? 137 VAL A C   1 ? 
ATOM   1047 O O   . VAL A 1 137 ? -19.764 -23.740 28.868 1.00 33.87  ? 137 VAL A O   1 ? 
ATOM   1048 C CB  . VAL A 1 137 ? -17.407 -24.729 30.906 1.00 47.37  ? 137 VAL A CB  1 ? 
ATOM   1049 C CG1 . VAL A 1 137 ? -17.620 -25.627 29.686 1.00 35.65  ? 137 VAL A CG1 1 ? 
ATOM   1050 C CG2 . VAL A 1 137 ? -15.922 -24.389 31.111 1.00 45.45  ? 137 VAL A CG2 1 ? 
ATOM   1051 N N   . ARG A 1 138 ? -20.597 -24.174 30.906 1.00 38.77  ? 138 ARG A N   1 ? 
ATOM   1052 C CA  . ARG A 1 138 ? -21.906 -24.473 30.349 1.00 27.79  ? 138 ARG A CA  1 ? 
ATOM   1053 C C   . ARG A 1 138 ? -22.642 -23.224 29.890 1.00 36.08  ? 138 ARG A C   1 ? 
ATOM   1054 O O   . ARG A 1 138 ? -23.460 -23.312 28.974 1.00 40.45  ? 138 ARG A O   1 ? 
ATOM   1055 C CB  . ARG A 1 138 ? -22.721 -25.277 31.349 1.00 51.98  ? 138 ARG A CB  1 ? 
ATOM   1056 C CG  . ARG A 1 138 ? -21.970 -26.536 31.783 1.00 57.24  ? 138 ARG A CG  1 ? 
ATOM   1057 C CD  . ARG A 1 138 ? -22.814 -27.481 32.602 1.00 74.83  ? 138 ARG A CD  1 ? 
ATOM   1058 N NE  . ARG A 1 138 ? -24.037 -27.868 31.897 1.00 96.68  ? 138 ARG A NE  1 ? 
ATOM   1059 C CZ  . ARG A 1 138 ? -24.319 -29.114 31.529 1.00 105.12 ? 138 ARG A CZ  1 ? 
ATOM   1060 N NH1 . ARG A 1 138 ? -23.459 -30.083 31.802 1.00 96.86  ? 138 ARG A NH1 1 ? 
ATOM   1061 N NH2 . ARG A 1 138 ? -25.451 -29.398 30.890 1.00 81.31  ? 138 ARG A NH2 1 ? 
ATOM   1062 N N   . LYS A 1 139 ? -22.347 -22.065 30.467 1.00 33.78  ? 139 LYS A N   1 ? 
ATOM   1063 C CA  . LYS A 1 139 ? -22.856 -20.811 29.925 1.00 45.83  ? 139 LYS A CA  1 ? 
ATOM   1064 C C   . LYS A 1 139 ? -22.198 -20.490 28.582 1.00 28.72  ? 139 LYS A C   1 ? 
ATOM   1065 O O   . LYS A 1 139 ? -22.874 -20.092 27.626 1.00 35.87  ? 139 LYS A O   1 ? 
ATOM   1066 C CB  . LYS A 1 139 ? -22.592 -19.683 30.934 1.00 61.87  ? 139 LYS A CB  1 ? 
ATOM   1067 C CG  . LYS A 1 139 ? -23.626 -19.529 32.070 1.00 66.07  ? 139 LYS A CG  1 ? 
ATOM   1068 C CD  . LYS A 1 139 ? -24.727 -18.523 31.691 1.00 89.55  ? 139 LYS A CD  1 ? 
ATOM   1069 C CE  . LYS A 1 139 ? -25.888 -18.461 32.698 1.00 99.40  ? 139 LYS A CE  1 ? 
ATOM   1070 N NZ  . LYS A 1 139 ? -27.096 -17.721 32.191 1.00 83.10  ? 139 LYS A NZ  1 ? 
ATOM   1071 N N   . ARG A 1 140 ? -20.873 -20.648 28.498 1.00 29.19  ? 140 ARG A N   1 ? 
ATOM   1072 C CA  . ARG A 1 140 ? -20.164 -20.358 27.259 1.00 32.67  ? 140 ARG A CA  1 ? 
ATOM   1073 C C   . ARG A 1 140 ? -20.657 -21.229 26.121 1.00 33.55  ? 140 ARG A C   1 ? 
ATOM   1074 O O   . ARG A 1 140 ? -20.668 -20.793 24.962 1.00 30.83  ? 140 ARG A O   1 ? 
ATOM   1075 C CB  . ARG A 1 140 ? -18.657 -20.573 27.425 1.00 30.88  ? 140 ARG A CB  1 ? 
ATOM   1076 C CG  . ARG A 1 140 ? -18.014 -19.581 28.319 1.00 36.60  ? 140 ARG A CG  1 ? 
ATOM   1077 C CD  . ARG A 1 140 ? -16.631 -20.021 28.716 1.00 33.48  ? 140 ARG A CD  1 ? 
ATOM   1078 N NE  . ARG A 1 140 ? -15.722 -20.179 27.604 1.00 40.83  ? 140 ARG A NE  1 ? 
ATOM   1079 C CZ  . ARG A 1 140 ? -14.548 -20.793 27.683 1.00 45.05  ? 140 ARG A CZ  1 ? 
ATOM   1080 N NH1 . ARG A 1 140 ? -14.145 -21.333 28.837 1.00 45.20  ? 140 ARG A NH1 1 ? 
ATOM   1081 N NH2 . ARG A 1 140 ? -13.780 -20.858 26.606 1.00 54.14  ? 140 ARG A NH2 1 ? 
ATOM   1082 N N   . LEU A 1 141 ? -21.042 -22.468 26.416 1.00 30.78  ? 141 LEU A N   1 ? 
ATOM   1083 C CA  . LEU A 1 141 ? -21.494 -23.349 25.348 1.00 30.89  ? 141 LEU A CA  1 ? 
ATOM   1084 C C   . LEU A 1 141 ? -22.877 -22.953 24.863 1.00 39.19  ? 141 LEU A C   1 ? 
ATOM   1085 O O   . LEU A 1 141 ? -23.196 -23.114 23.682 1.00 29.61  ? 141 LEU A O   1 ? 
ATOM   1086 C CB  . LEU A 1 141 ? -21.515 -24.798 25.822 1.00 33.81  ? 141 LEU A CB  1 ? 
ATOM   1087 C CG  . LEU A 1 141 ? -20.313 -25.654 25.493 1.00 41.28  ? 141 LEU A CG  1 ? 
ATOM   1088 C CD1 . LEU A 1 141 ? -20.459 -27.056 26.059 1.00 46.35  ? 141 LEU A CD1 1 ? 
ATOM   1089 C CD2 . LEU A 1 141 ? -20.193 -25.620 23.983 1.00 38.74  ? 141 LEU A CD2 1 ? 
ATOM   1090 N N   . VAL A 1 142 ? -23.729 -22.477 25.765 1.00 29.84  ? 142 VAL A N   1 ? 
ATOM   1091 C CA  . VAL A 1 142 ? -25.028 -22.010 25.322 1.00 35.31  ? 142 VAL A CA  1 ? 
ATOM   1092 C C   . VAL A 1 142 ? -24.863 -20.774 24.453 1.00 33.25  ? 142 VAL A C   1 ? 
ATOM   1093 O O   . VAL A 1 142 ? -25.442 -20.674 23.372 1.00 39.87  ? 142 VAL A O   1 ? 
ATOM   1094 C CB  . VAL A 1 142 ? -25.926 -21.727 26.533 1.00 44.17  ? 142 VAL A CB  1 ? 
ATOM   1095 C CG1 . VAL A 1 142 ? -27.237 -21.153 26.068 1.00 51.85  ? 142 VAL A CG1 1 ? 
ATOM   1096 C CG2 . VAL A 1 142 ? -26.108 -22.995 27.308 1.00 46.93  ? 142 VAL A CG2 1 ? 
ATOM   1097 N N   . GLU A 1 143 ? -24.053 -19.826 24.897 1.00 32.01  ? 143 GLU A N   1 ? 
ATOM   1098 C CA  . GLU A 1 143 ? -23.772 -18.670 24.059 1.00 33.93  ? 143 GLU A CA  1 ? 
ATOM   1099 C C   . GLU A 1 143 ? -23.224 -19.092 22.705 1.00 30.67  ? 143 GLU A C   1 ? 
ATOM   1100 O O   . GLU A 1 143 ? -23.604 -18.517 21.672 1.00 28.67  ? 143 GLU A O   1 ? 
ATOM   1101 C CB  . GLU A 1 143 ? -22.779 -17.743 24.745 1.00 33.42  ? 143 GLU A CB  1 ? 
ATOM   1102 C CG  . GLU A 1 143 ? -23.420 -16.893 25.818 1.00 50.36  ? 143 GLU A CG  1 ? 
ATOM   1103 C CD  . GLU A 1 143 ? -23.486 -15.444 25.434 1.00 51.20  ? 143 GLU A CD  1 ? 
ATOM   1104 O OE1 . GLU A 1 143 ? -22.880 -14.617 26.166 1.00 56.18  ? 143 GLU A OE1 1 ? 
ATOM   1105 O OE2 . GLU A 1 143 ? -24.074 -15.127 24.375 1.00 59.38  ? 143 GLU A OE2 1 ? 
ATOM   1106 N N   . TYR A 1 144 ? -22.277 -20.042 22.709 1.00 24.05  ? 144 TYR A N   1 ? 
ATOM   1107 C CA  . TYR A 1 144 ? -21.713 -20.585 21.465 1.00 24.23  ? 144 TYR A CA  1 ? 
ATOM   1108 C C   . TYR A 1 144 ? -22.819 -21.010 20.512 1.00 25.69  ? 144 TYR A C   1 ? 
ATOM   1109 O O   . TYR A 1 144 ? -22.846 -20.569 19.346 1.00 23.60  ? 144 TYR A O   1 ? 
ATOM   1110 C CB  . TYR A 1 144 ? -20.757 -21.787 21.733 1.00 26.52  ? 144 TYR A CB  1 ? 
ATOM   1111 C CG  . TYR A 1 144 ? -20.389 -22.496 20.420 1.00 26.53  ? 144 TYR A CG  1 ? 
ATOM   1112 C CD1 . TYR A 1 144 ? -20.995 -23.689 20.014 1.00 26.17  ? 144 TYR A CD1 1 ? 
ATOM   1113 C CD2 . TYR A 1 144 ? -19.497 -21.892 19.550 1.00 25.33  ? 144 TYR A CD2 1 ? 
ATOM   1114 C CE1 . TYR A 1 144 ? -20.668 -24.272 18.756 1.00 28.65  ? 144 TYR A CE1 1 ? 
ATOM   1115 C CE2 . TYR A 1 144 ? -19.179 -22.451 18.334 1.00 25.73  ? 144 TYR A CE2 1 ? 
ATOM   1116 C CZ  . TYR A 1 144 ? -19.752 -23.619 17.935 1.00 25.13  ? 144 TYR A CZ  1 ? 
ATOM   1117 O OH  . TYR A 1 144 ? -19.361 -24.089 16.691 1.00 30.41  ? 144 TYR A OH  1 ? 
ATOM   1118 N N   . HIS A 1 145 ? -23.776 -21.839 20.993 1.00 21.86  ? 145 HIS A N   1 ? 
ATOM   1119 C CA  . HIS A 1 145 ? -24.790 -22.403 20.078 1.00 27.84  ? 145 HIS A CA  1 ? 
ATOM   1120 C C   . HIS A 1 145 ? -25.746 -21.345 19.557 1.00 31.10  ? 145 HIS A C   1 ? 
ATOM   1121 O O   . HIS A 1 145 ? -26.271 -21.499 18.449 1.00 26.00  ? 145 HIS A O   1 ? 
ATOM   1122 C CB  . HIS A 1 145 ? -25.566 -23.576 20.725 1.00 31.06  ? 145 HIS A CB  1 ? 
ATOM   1123 C CG  . HIS A 1 145 ? -24.742 -24.822 20.723 1.00 32.51  ? 145 HIS A CG  1 ? 
ATOM   1124 N ND1 . HIS A 1 145 ? -24.344 -25.419 19.546 1.00 35.77  ? 145 HIS A ND1 1 ? 
ATOM   1125 C CD2 . HIS A 1 145 ? -24.099 -25.480 21.717 1.00 32.75  ? 145 HIS A CD2 1 ? 
ATOM   1126 C CE1 . HIS A 1 145 ? -23.513 -26.411 19.813 1.00 36.70  ? 145 HIS A CE1 1 ? 
ATOM   1127 N NE2 . HIS A 1 145 ? -23.359 -26.478 21.122 1.00 43.07  ? 145 HIS A NE2 1 ? 
ATOM   1128 N N   . GLN A 1 146 ? -25.935 -20.246 20.293 1.00 28.06  ? 146 GLN A N   1 ? 
ATOM   1129 C CA  . GLN A 1 146 ? -26.853 -19.193 19.861 1.00 37.26  ? 146 GLN A CA  1 ? 
ATOM   1130 C C   . GLN A 1 146 ? -26.175 -18.133 18.986 1.00 26.98  ? 146 GLN A C   1 ? 
ATOM   1131 O O   . GLN A 1 146 ? -26.793 -17.635 18.040 1.00 26.50  ? 146 GLN A O   1 ? 
ATOM   1132 C CB  . GLN A 1 146 ? -27.492 -18.539 21.105 1.00 44.56  ? 146 GLN A CB  1 ? 
ATOM   1133 C CG  . GLN A 1 146 ? -28.533 -19.452 21.805 1.00 37.32  ? 146 GLN A CG  1 ? 
ATOM   1134 C CD  . GLN A 1 146 ? -29.696 -19.874 20.873 1.00 54.23  ? 146 GLN A CD  1 ? 
ATOM   1135 O OE1 . GLN A 1 146 ? -30.041 -21.066 20.759 1.00 53.56  ? 146 GLN A OE1 1 ? 
ATOM   1136 N NE2 . GLN A 1 146 ? -30.311 -18.897 20.224 1.00 46.44  ? 146 GLN A NE2 1 ? 
ATOM   1137 N N   . MET A 1 147 ? -24.918 -17.792 19.281 1.00 26.72  ? 147 MET A N   1 ? 
ATOM   1138 C CA  . MET A 1 147 ? -24.256 -16.656 18.651 1.00 25.74  ? 147 MET A CA  1 ? 
ATOM   1139 C C   . MET A 1 147 ? -23.175 -17.040 17.653 1.00 23.19  ? 147 MET A C   1 ? 
ATOM   1140 O O   . MET A 1 147 ? -22.965 -16.309 16.669 1.00 20.52  ? 147 MET A O   1 ? 
ATOM   1141 C CB  . MET A 1 147 ? -23.627 -15.748 19.694 1.00 19.28  ? 147 MET A CB  1 ? 
ATOM   1142 C CG  . MET A 1 147 ? -24.545 -15.319 20.835 1.00 49.96  ? 147 MET A CG  1 ? 
ATOM   1143 S SD  . MET A 1 147 ? -25.967 -14.384 20.213 1.00 45.19  ? 147 MET A SD  1 ? 
ATOM   1144 C CE  . MET A 1 147 ? -25.258 -13.196 18.996 1.00 51.67  ? 147 MET A CE  1 ? 
ATOM   1145 N N   . THR A 1 148 ? -22.465 -18.138 17.879 1.00 18.24  ? 148 THR A N   1 ? 
ATOM   1146 C CA  . THR A 1 148 ? -21.253 -18.458 17.139 1.00 18.31  ? 148 THR A CA  1 ? 
ATOM   1147 C C   . THR A 1 148 ? -21.450 -19.567 16.133 1.00 18.77  ? 148 THR A C   1 ? 
ATOM   1148 O O   . THR A 1 148 ? -20.890 -19.511 15.035 1.00 18.72  ? 148 THR A O   1 ? 
ATOM   1149 C CB  . THR A 1 148 ? -20.179 -18.867 18.156 1.00 22.30  ? 148 THR A CB  1 ? 
ATOM   1150 O OG1 . THR A 1 148 ? -20.123 -17.858 19.195 1.00 22.77  ? 148 THR A OG1 1 ? 
ATOM   1151 C CG2 . THR A 1 148 ? -18.789 -19.026 17.557 1.00 21.47  ? 148 THR A CG2 1 ? 
ATOM   1152 N N   . ALA A 1 149 ? -22.224 -20.587 16.485 1.00 22.78  ? 149 ALA A N   1 ? 
ATOM   1153 C CA  . ALA A 1 149 ? -22.377 -21.719 15.588 1.00 24.82  ? 149 ALA A CA  1 ? 
ATOM   1154 C C   . ALA A 1 149 ? -22.984 -21.327 14.253 1.00 18.86  ? 149 ALA A C   1 ? 
ATOM   1155 O O   . ALA A 1 149 ? -22.687 -22.004 13.264 1.00 24.75  ? 149 ALA A O   1 ? 
ATOM   1156 C CB  . ALA A 1 149 ? -23.238 -22.817 16.239 1.00 18.86  ? 149 ALA A CB  1 ? 
ATOM   1157 N N   . PRO A 1 150 ? -23.828 -20.298 14.150 1.00 15.41  ? 150 PRO A N   1 ? 
ATOM   1158 C CA  . PRO A 1 150 ? -24.326 -19.910 12.824 1.00 20.89  ? 150 PRO A CA  1 ? 
ATOM   1159 C C   . PRO A 1 150 ? -23.224 -19.536 11.826 1.00 20.64  ? 150 PRO A C   1 ? 
ATOM   1160 O O   . PRO A 1 150 ? -23.482 -19.537 10.612 1.00 20.91  ? 150 PRO A O   1 ? 
ATOM   1161 C CB  . PRO A 1 150 ? -25.236 -18.730 13.147 1.00 22.20  ? 150 PRO A CB  1 ? 
ATOM   1162 C CG  . PRO A 1 150 ? -25.731 -19.020 14.546 1.00 19.43  ? 150 PRO A CG  1 ? 
ATOM   1163 C CD  . PRO A 1 150 ? -24.580 -19.643 15.230 1.00 21.21  ? 150 PRO A CD  1 ? 
ATOM   1164 N N   . LEU A 1 151 ? -22.007 -19.230 12.304 1.00 18.60  ? 151 LEU A N   1 ? 
ATOM   1165 C CA  . LEU A 1 151 ? -20.860 -18.995 11.419 1.00 16.16  ? 151 LEU A CA  1 ? 
ATOM   1166 C C   . LEU A 1 151 ? -20.538 -20.204 10.562 1.00 20.92  ? 151 LEU A C   1 ? 
ATOM   1167 O O   . LEU A 1 151 ? -19.958 -20.043 9.488  1.00 19.55  ? 151 LEU A O   1 ? 
ATOM   1168 C CB  . LEU A 1 151 ? -19.623 -18.637 12.262 1.00 18.55  ? 151 LEU A CB  1 ? 
ATOM   1169 C CG  . LEU A 1 151 ? -19.668 -17.238 12.852 1.00 19.51  ? 151 LEU A CG  1 ? 
ATOM   1170 C CD1 . LEU A 1 151 ? -18.463 -16.897 13.750 1.00 20.44  ? 151 LEU A CD1 1 ? 
ATOM   1171 C CD2 . LEU A 1 151 ? -19.885 -16.152 11.760 1.00 23.83  ? 151 LEU A CD2 1 ? 
ATOM   1172 N N   . ILE A 1 152 ? -20.871 -21.414 11.031 1.00 22.17  ? 152 ILE A N   1 ? 
ATOM   1173 C CA  . ILE A 1 152 ? -20.656 -22.602 10.219 1.00 22.55  ? 152 ILE A CA  1 ? 
ATOM   1174 C C   . ILE A 1 152 ? -21.392 -22.454 8.888  1.00 19.00  ? 152 ILE A C   1 ? 
ATOM   1175 O O   . ILE A 1 152 ? -20.802 -22.571 7.813  1.00 18.40  ? 152 ILE A O   1 ? 
ATOM   1176 C CB  . ILE A 1 152 ? -21.092 -23.850 11.001 1.00 24.11  ? 152 ILE A CB  1 ? 
ATOM   1177 C CG1 . ILE A 1 152 ? -20.145 -24.066 12.181 1.00 23.10  ? 152 ILE A CG1 1 ? 
ATOM   1178 C CG2 . ILE A 1 152 ? -21.166 -25.042 10.062 1.00 28.60  ? 152 ILE A CG2 1 ? 
ATOM   1179 C CD1 . ILE A 1 152 ? -20.676 -25.056 13.206 1.00 36.00  ? 152 ILE A CD1 1 ? 
ATOM   1180 N N   . GLY A 1 153 ? -22.675 -22.122 8.938  1.00 23.44  ? 153 GLY A N   1 ? 
ATOM   1181 C CA  . GLY A 1 153 ? -23.407 -21.858 7.713  1.00 23.99  ? 153 GLY A CA  1 ? 
ATOM   1182 C C   . GLY A 1 153 ? -22.994 -20.573 7.009  1.00 26.48  ? 153 GLY A C   1 ? 
ATOM   1183 O O   . GLY A 1 153 ? -23.010 -20.500 5.778  1.00 19.51  ? 153 GLY A O   1 ? 
ATOM   1184 N N   . TYR A 1 154 ? -22.672 -19.526 7.763  1.00 23.85  ? 154 TYR A N   1 ? 
ATOM   1185 C CA  . TYR A 1 154 ? -22.220 -18.301 7.118  1.00 18.01  ? 154 TYR A CA  1 ? 
ATOM   1186 C C   . TYR A 1 154 ? -21.041 -18.592 6.210  1.00 22.23  ? 154 TYR A C   1 ? 
ATOM   1187 O O   . TYR A 1 154 ? -21.026 -18.176 5.050  1.00 18.27  ? 154 TYR A O   1 ? 
ATOM   1188 C CB  . TYR A 1 154 ? -21.868 -17.267 8.183  1.00 20.85  ? 154 TYR A CB  1 ? 
ATOM   1189 C CG  . TYR A 1 154 ? -21.406 -15.938 7.705  1.00 24.85  ? 154 TYR A CG  1 ? 
ATOM   1190 C CD1 . TYR A 1 154 ? -22.257 -14.851 7.685  1.00 32.00  ? 154 TYR A CD1 1 ? 
ATOM   1191 C CD2 . TYR A 1 154 ? -20.076 -15.735 7.351  1.00 22.00  ? 154 TYR A CD2 1 ? 
ATOM   1192 C CE1 . TYR A 1 154 ? -21.821 -13.618 7.311  1.00 31.68  ? 154 TYR A CE1 1 ? 
ATOM   1193 C CE2 . TYR A 1 154 ? -19.631 -14.509 6.955  1.00 28.09  ? 154 TYR A CE2 1 ? 
ATOM   1194 C CZ  . TYR A 1 154 ? -20.503 -13.448 6.946  1.00 34.19  ? 154 TYR A CZ  1 ? 
ATOM   1195 O OH  . TYR A 1 154 ? -20.055 -12.206 6.568  1.00 32.62  ? 154 TYR A OH  1 ? 
ATOM   1196 N N   . TYR A 1 155 ? -20.056 -19.338 6.701  1.00 16.85  ? 155 TYR A N   1 ? 
ATOM   1197 C CA  . TYR A 1 155 ? -18.883 -19.529 5.868  1.00 15.37  ? 155 TYR A CA  1 ? 
ATOM   1198 C C   . TYR A 1 155 ? -19.023 -20.701 4.915  1.00 17.08  ? 155 TYR A C   1 ? 
ATOM   1199 O O   . TYR A 1 155 ? -18.290 -20.749 3.918  1.00 23.84  ? 155 TYR A O   1 ? 
ATOM   1200 C CB  . TYR A 1 155 ? -17.640 -19.697 6.715  1.00 17.40  ? 155 TYR A CB  1 ? 
ATOM   1201 C CG  . TYR A 1 155 ? -17.143 -18.388 7.252  1.00 16.17  ? 155 TYR A CG  1 ? 
ATOM   1202 C CD1 . TYR A 1 155 ? -16.637 -17.412 6.403  1.00 16.01  ? 155 TYR A CD1 1 ? 
ATOM   1203 C CD2 . TYR A 1 155 ? -17.208 -18.112 8.598  1.00 14.66  ? 155 TYR A CD2 1 ? 
ATOM   1204 C CE1 . TYR A 1 155 ? -16.172 -16.226 6.910  1.00 16.93  ? 155 TYR A CE1 1 ? 
ATOM   1205 C CE2 . TYR A 1 155 ? -16.760 -16.939 9.106  1.00 17.65  ? 155 TYR A CE2 1 ? 
ATOM   1206 C CZ  . TYR A 1 155 ? -16.249 -16.000 8.265  1.00 16.29  ? 155 TYR A CZ  1 ? 
ATOM   1207 O OH  . TYR A 1 155 ? -15.822 -14.830 8.821  1.00 24.00  ? 155 TYR A OH  1 ? 
ATOM   1208 N N   . SER A 1 156 ? -19.926 -21.642 5.187  1.00 19.11  ? 156 SER A N   1 ? 
ATOM   1209 C CA  . SER A 1 156 ? -20.269 -22.646 4.182  1.00 32.63  ? 156 SER A CA  1 ? 
ATOM   1210 C C   . SER A 1 156 ? -20.870 -21.981 2.956  1.00 24.92  ? 156 SER A C   1 ? 
ATOM   1211 O O   . SER A 1 156 ? -20.506 -22.307 1.828  1.00 24.58  ? 156 SER A O   1 ? 
ATOM   1212 C CB  . SER A 1 156 ? -21.220 -23.679 4.787  1.00 26.57  ? 156 SER A CB  1 ? 
ATOM   1213 O OG  . SER A 1 156 ? -20.536 -24.385 5.811  1.00 37.20  ? 156 SER A OG  1 ? 
ATOM   1214 N N   . LYS A 1 157 ? -21.727 -20.981 3.167  1.00 22.75  ? 157 LYS A N   1 ? 
ATOM   1215 C CA  . LYS A 1 157 ? -22.248 -20.194 2.048  1.00 24.53  ? 157 LYS A CA  1 ? 
ATOM   1216 C C   . LYS A 1 157 ? -21.147 -19.388 1.339  1.00 27.31  ? 157 LYS A C   1 ? 
ATOM   1217 O O   . LYS A 1 157 ? -21.146 -19.289 0.109  1.00 29.70  ? 157 LYS A O   1 ? 
ATOM   1218 C CB  . LYS A 1 157 ? -23.343 -19.229 2.523  1.00 27.60  ? 157 LYS A CB  1 ? 
ATOM   1219 C CG  . LYS A 1 157 ? -24.684 -19.779 3.033  1.00 44.55  ? 157 LYS A CG  1 ? 
ATOM   1220 C CD  . LYS A 1 157 ? -25.685 -18.601 3.402  1.00 59.31  ? 157 LYS A CD  1 ? 
ATOM   1221 C CE  . LYS A 1 157 ? -25.115 -17.505 4.387  1.00 57.74  ? 157 LYS A CE  1 ? 
ATOM   1222 N NZ  . LYS A 1 157 ? -26.053 -16.965 5.473  1.00 48.06  ? 157 LYS A NZ  1 ? 
ATOM   1223 N N   . GLU A 1 158 ? -20.237 -18.739 2.091  1.00 26.60  ? 158 GLU A N   1 ? 
ATOM   1224 C CA  . GLU A 1 158 ? -19.136 -18.011 1.445  1.00 26.79  ? 158 GLU A CA  1 ? 
ATOM   1225 C C   . GLU A 1 158 ? -18.321 -18.910 0.517  1.00 30.14  ? 158 GLU A C   1 ? 
ATOM   1226 O O   . GLU A 1 158 ? -17.851 -18.466 -0.550 1.00 25.33  ? 158 GLU A O   1 ? 
ATOM   1227 C CB  . GLU A 1 158 ? -18.187 -17.425 2.482  1.00 20.89  ? 158 GLU A CB  1 ? 
ATOM   1228 C CG  . GLU A 1 158 ? -18.649 -16.145 3.134  1.00 29.83  ? 158 GLU A CG  1 ? 
ATOM   1229 C CD  . GLU A 1 158 ? -18.623 -15.009 2.162  1.00 47.87  ? 158 GLU A CD  1 ? 
ATOM   1230 O OE1 . GLU A 1 158 ? -17.512 -14.503 1.913  1.00 47.84  ? 158 GLU A OE1 1 ? 
ATOM   1231 O OE2 . GLU A 1 158 ? -19.694 -14.664 1.610  1.00 47.14  ? 158 GLU A OE2 1 ? 
ATOM   1232 N N   . ALA A 1 159 ? -18.062 -20.157 0.947  1.00 24.47  ? 159 ALA A N   1 ? 
ATOM   1233 C CA  . ALA A 1 159 ? -17.273 -21.059 0.112  1.00 30.16  ? 159 ALA A CA  1 ? 
ATOM   1234 C C   . ALA A 1 159 ? -18.050 -21.474 -1.130 1.00 28.53  ? 159 ALA A C   1 ? 
ATOM   1235 O O   . ALA A 1 159 ? -17.464 -21.673 -2.193 1.00 26.68  ? 159 ALA A O   1 ? 
ATOM   1236 C CB  . ALA A 1 159 ? -16.875 -22.311 0.893  1.00 32.41  ? 159 ALA A CB  1 ? 
ATOM   1237 N N   . GLU A 1 160 ? -19.365 -21.634 -1.005 1.00 31.13  ? 160 GLU A N   1 ? 
ATOM   1238 C CA  . GLU A 1 160 ? -20.188 -21.924 -2.173 1.00 34.85  ? 160 GLU A CA  1 ? 
ATOM   1239 C C   . GLU A 1 160 ? -20.079 -20.808 -3.208 1.00 36.31  ? 160 GLU A C   1 ? 
ATOM   1240 O O   . GLU A 1 160 ? -20.068 -21.066 -4.416 1.00 34.25  ? 160 GLU A O   1 ? 
ATOM   1241 C CB  . GLU A 1 160 ? -21.648 -22.107 -1.742 1.00 35.82  ? 160 GLU A CB  1 ? 
ATOM   1242 C CG  . GLU A 1 160 ? -22.009 -23.551 -1.360 1.00 49.74  ? 160 GLU A CG  1 ? 
ATOM   1243 C CD  . GLU A 1 160 ? -23.324 -23.682 -0.585 1.00 68.55  ? 160 GLU A CD  1 ? 
ATOM   1244 O OE1 . GLU A 1 160 ? -24.104 -22.700 -0.520 1.00 79.43  ? 160 GLU A OE1 1 ? 
ATOM   1245 O OE2 . GLU A 1 160 ? -23.593 -24.792 -0.069 1.00 84.34  ? 160 GLU A OE2 1 ? 
ATOM   1246 N N   . ALA A 1 161 ? -20.006 -19.559 -2.751 1.00 34.93  ? 161 ALA A N   1 ? 
ATOM   1247 C CA  . ALA A 1 161 ? -19.855 -18.403 -3.621 1.00 29.49  ? 161 ALA A CA  1 ? 
ATOM   1248 C C   . ALA A 1 161 ? -18.432 -18.233 -4.128 1.00 32.94  ? 161 ALA A C   1 ? 
ATOM   1249 O O   . ALA A 1 161 ? -18.153 -17.257 -4.828 1.00 38.73  ? 161 ALA A O   1 ? 
ATOM   1250 C CB  . ALA A 1 161 ? -20.288 -17.153 -2.868 1.00 29.46  ? 161 ALA A CB  1 ? 
ATOM   1251 N N   . GLY A 1 162 ? -17.537 -19.161 -3.801 1.00 34.06  ? 162 GLY A N   1 ? 
ATOM   1252 C CA  . GLY A 1 162 ? -16.157 -19.076 -4.216 1.00 24.23  ? 162 GLY A CA  1 ? 
ATOM   1253 C C   . GLY A 1 162 ? -15.299 -18.140 -3.408 1.00 28.81  ? 162 GLY A C   1 ? 
ATOM   1254 O O   . GLY A 1 162 ? -14.220 -17.779 -3.871 1.00 25.40  ? 162 GLY A O   1 ? 
ATOM   1255 N N   . ASN A 1 163 ? -15.732 -17.706 -2.224 1.00 25.29  ? 163 ASN A N   1 ? 
ATOM   1256 C CA  . ASN A 1 163 ? -14.946 -16.691 -1.536 1.00 26.19  ? 163 ASN A CA  1 ? 
ATOM   1257 C C   . ASN A 1 163 ? -13.919 -17.266 -0.570 1.00 30.67  ? 163 ASN A C   1 ? 
ATOM   1258 O O   . ASN A 1 163 ? -13.029 -16.521 -0.133 1.00 34.63  ? 163 ASN A O   1 ? 
ATOM   1259 C CB  . ASN A 1 163 ? -15.829 -15.748 -0.765 1.00 32.52  ? 163 ASN A CB  1 ? 
ATOM   1260 C CG  . ASN A 1 163 ? -16.643 -14.875 -1.671 1.00 43.23  ? 163 ASN A CG  1 ? 
ATOM   1261 O OD1 . ASN A 1 163 ? -16.194 -14.494 -2.755 1.00 36.54  ? 163 ASN A OD1 1 ? 
ATOM   1262 N ND2 . ASN A 1 163 ? -17.863 -14.584 -1.258 1.00 35.75  ? 163 ASN A ND2 1 ? 
ATOM   1263 N N   . THR A 1 164 ? -14.045 -18.540 -0.198 1.00 25.25  ? 164 THR A N   1 ? 
ATOM   1264 C CA  . THR A 1 164 ? -13.094 -19.191 0.682  1.00 23.12  ? 164 THR A CA  1 ? 
ATOM   1265 C C   . THR A 1 164 ? -13.235 -20.679 0.420  1.00 29.76  ? 164 THR A C   1 ? 
ATOM   1266 O O   . THR A 1 164 ? -14.096 -21.102 -0.353 1.00 28.38  ? 164 THR A O   1 ? 
ATOM   1267 C CB  . THR A 1 164 ? -13.351 -18.797 2.138  1.00 31.03  ? 164 THR A CB  1 ? 
ATOM   1268 O OG1 . THR A 1 164 ? -12.244 -19.262 2.949  1.00 33.53  ? 164 THR A OG1 1 ? 
ATOM   1269 C CG2 . THR A 1 164 ? -14.668 -19.410 2.675  1.00 25.19  ? 164 THR A CG2 1 ? 
ATOM   1270 N N   . LYS A 1 165 ? -12.375 -21.473 1.051  1.00 29.19  ? 165 LYS A N   1 ? 
ATOM   1271 C CA  . LYS A 1 165 ? -12.535 -22.919 1.123  1.00 21.42  ? 165 LYS A CA  1 ? 
ATOM   1272 C C   . LYS A 1 165 ? -12.993 -23.298 2.524  1.00 23.50  ? 165 LYS A C   1 ? 
ATOM   1273 O O   . LYS A 1 165 ? -12.512 -22.750 3.513  1.00 25.18  ? 165 LYS A O   1 ? 
ATOM   1274 C CB  . LYS A 1 165 ? -11.212 -23.617 0.756  1.00 27.44  ? 165 LYS A CB  1 ? 
ATOM   1275 C CG  . LYS A 1 165 ? -10.761 -23.293 -0.681 1.00 37.65  ? 165 LYS A CG  1 ? 
ATOM   1276 C CD  . LYS A 1 165 ? -9.613  -24.177 -1.156 1.00 42.15  ? 165 LYS A CD  1 ? 
ATOM   1277 C CE  . LYS A 1 165 ? -8.897  -23.598 -2.373 1.00 50.04  ? 165 LYS A CE  1 ? 
ATOM   1278 N NZ  . LYS A 1 165 ? -7.532  -24.225 -2.464 1.00 56.29  ? 165 LYS A NZ  1 ? 
ATOM   1279 N N   . TYR A 1 166 ? -13.960 -24.190 2.609  1.00 21.76  ? 166 TYR A N   1 ? 
ATOM   1280 C CA  . TYR A 1 166 ? -14.575 -24.580 3.880  1.00 21.72  ? 166 TYR A CA  1 ? 
ATOM   1281 C C   . TYR A 1 166 ? -14.360 -26.067 4.103  1.00 25.05  ? 166 TYR A C   1 ? 
ATOM   1282 O O   . TYR A 1 166 ? -14.662 -26.864 3.221  1.00 24.12  ? 166 TYR A O   1 ? 
ATOM   1283 C CB  . TYR A 1 166 ? -16.063 -24.257 3.902  1.00 27.02  ? 166 TYR A CB  1 ? 
ATOM   1284 C CG  . TYR A 1 166 ? -16.667 -24.551 5.242  1.00 25.57  ? 166 TYR A CG  1 ? 
ATOM   1285 C CD1 . TYR A 1 166 ? -17.147 -25.822 5.566  1.00 24.43  ? 166 TYR A CD1 1 ? 
ATOM   1286 C CD2 . TYR A 1 166 ? -16.727 -23.567 6.182  1.00 26.19  ? 166 TYR A CD2 1 ? 
ATOM   1287 C CE1 . TYR A 1 166 ? -17.669 -26.058 6.812  1.00 26.20  ? 166 TYR A CE1 1 ? 
ATOM   1288 C CE2 . TYR A 1 166 ? -17.223 -23.784 7.385  1.00 31.11  ? 166 TYR A CE2 1 ? 
ATOM   1289 C CZ  . TYR A 1 166 ? -17.697 -25.005 7.712  1.00 30.19  ? 166 TYR A CZ  1 ? 
ATOM   1290 O OH  . TYR A 1 166 ? -18.170 -25.032 8.991  1.00 35.24  ? 166 TYR A OH  1 ? 
ATOM   1291 N N   . ALA A 1 167 ? -13.858 -26.452 5.282  1.00 22.46  ? 167 ALA A N   1 ? 
ATOM   1292 C CA  . ALA A 1 167 ? -13.761 -27.865 5.600  1.00 33.07  ? 167 ALA A CA  1 ? 
ATOM   1293 C C   . ALA A 1 167 ? -14.087 -28.102 7.072  1.00 32.11  ? 167 ALA A C   1 ? 
ATOM   1294 O O   . ALA A 1 167 ? -13.921 -27.218 7.921  1.00 23.55  ? 167 ALA A O   1 ? 
ATOM   1295 C CB  . ALA A 1 167 ? -12.368 -28.424 5.305  1.00 30.08  ? 167 ALA A CB  1 ? 
ATOM   1296 N N   . LYS A 1 168 ? -14.566 -29.304 7.360  1.00 23.07  ? 168 LYS A N   1 ? 
ATOM   1297 C CA  . LYS A 1 168 ? -14.880 -29.754 8.712  1.00 27.51  ? 168 LYS A CA  1 ? 
ATOM   1298 C C   . LYS A 1 168 ? -13.922 -30.882 9.068  1.00 27.92  ? 168 LYS A C   1 ? 
ATOM   1299 O O   . LYS A 1 168 ? -13.658 -31.742 8.231  1.00 28.09  ? 168 LYS A O   1 ? 
ATOM   1300 C CB  . LYS A 1 168 ? -16.329 -30.212 8.756  1.00 29.91  ? 168 LYS A CB  1 ? 
ATOM   1301 C CG  . LYS A 1 168 ? -16.877 -30.571 10.111 1.00 34.03  ? 168 LYS A CG  1 ? 
ATOM   1302 C CD  . LYS A 1 168 ? -18.406 -30.676 10.024 1.00 48.28  ? 168 LYS A CD  1 ? 
ATOM   1303 C CE  . LYS A 1 168 ? -19.002 -31.740 10.973 1.00 65.75  ? 168 LYS A CE  1 ? 
ATOM   1304 N NZ  . LYS A 1 168 ? -20.512 -31.737 11.063 1.00 66.16  ? 168 LYS A NZ  1 ? 
ATOM   1305 N N   . VAL A 1 169 ? -13.373 -30.878 10.297 1.00 25.17  ? 169 VAL A N   1 ? 
ATOM   1306 C CA  . VAL A 1 169 ? -12.646 -32.041 10.813 1.00 25.42  ? 169 VAL A CA  1 ? 
ATOM   1307 C C   . VAL A 1 169 ? -13.322 -32.537 12.087 1.00 33.31  ? 169 VAL A C   1 ? 
ATOM   1308 O O   . VAL A 1 169 ? -13.918 -31.765 12.846 1.00 22.10  ? 169 VAL A O   1 ? 
ATOM   1309 C CB  . VAL A 1 169 ? -11.155 -31.760 11.109 1.00 27.79  ? 169 VAL A CB  1 ? 
ATOM   1310 C CG1 . VAL A 1 169 ? -10.482 -31.250 9.864  1.00 43.28  ? 169 VAL A CG1 1 ? 
ATOM   1311 C CG2 . VAL A 1 169 ? -10.993 -30.791 12.258 1.00 29.69  ? 169 VAL A CG2 1 ? 
ATOM   1312 N N   . ASP A 1 170 ? -13.204 -33.837 12.330 1.00 27.30  ? 170 ASP A N   1 ? 
ATOM   1313 C CA  . ASP A 1 170 ? -13.766 -34.492 13.516 1.00 23.34  ? 170 ASP A CA  1 ? 
ATOM   1314 C C   . ASP A 1 170 ? -12.764 -34.322 14.643 1.00 24.19  ? 170 ASP A C   1 ? 
ATOM   1315 O O   . ASP A 1 170 ? -11.741 -35.005 14.689 1.00 26.32  ? 170 ASP A O   1 ? 
ATOM   1316 C CB  . ASP A 1 170 ? -14.065 -35.956 13.187 1.00 31.62  ? 170 ASP A CB  1 ? 
ATOM   1317 C CG  . ASP A 1 170 ? -14.313 -36.826 14.398 1.00 40.10  ? 170 ASP A CG  1 ? 
ATOM   1318 O OD1 . ASP A 1 170 ? -14.485 -36.325 15.543 1.00 30.28  ? 170 ASP A OD1 1 ? 
ATOM   1319 O OD2 . ASP A 1 170 ? -14.339 -38.051 14.169 1.00 36.50  ? 170 ASP A OD2 1 ? 
ATOM   1320 N N   . GLY A 1 171 ? -13.050 -33.393 15.538 1.00 22.84  ? 171 GLY A N   1 ? 
ATOM   1321 C CA  . GLY A 1 171 ? -12.171 -33.047 16.641 1.00 17.91  ? 171 GLY A CA  1 ? 
ATOM   1322 C C   . GLY A 1 171 ? -12.184 -34.012 17.799 1.00 27.21  ? 171 GLY A C   1 ? 
ATOM   1323 O O   . GLY A 1 171 ? -11.523 -33.730 18.803 1.00 26.49  ? 171 GLY A O   1 ? 
ATOM   1324 N N   . THR A 1 172 ? -12.909 -35.140 17.706 1.00 25.16  ? 172 THR A N   1 ? 
ATOM   1325 C CA  . THR A 1 172 ? -12.872 -36.149 18.777 1.00 26.33  ? 172 THR A CA  1 ? 
ATOM   1326 C C   . THR A 1 172 ? -11.714 -37.125 18.603 1.00 24.65  ? 172 THR A C   1 ? 
ATOM   1327 O O   . THR A 1 172 ? -11.325 -37.792 19.562 1.00 30.24  ? 172 THR A O   1 ? 
ATOM   1328 C CB  . THR A 1 172 ? -14.207 -36.910 18.832 1.00 27.25  ? 172 THR A CB  1 ? 
ATOM   1329 O OG1 . THR A 1 172 ? -14.358 -37.799 17.700 1.00 29.90  ? 172 THR A OG1 1 ? 
ATOM   1330 C CG2 . THR A 1 172 ? -15.377 -35.914 18.904 1.00 26.02  ? 172 THR A CG2 1 ? 
ATOM   1331 N N   . LYS A 1 173 ? -11.165 -37.209 17.383 1.00 21.65  ? 173 LYS A N   1 ? 
ATOM   1332 C CA  . LYS A 1 173 ? -9.982  -37.972 17.106 1.00 21.01  ? 173 LYS A CA  1 ? 
ATOM   1333 C C   . LYS A 1 173 ? -8.814  -37.445 17.939 1.00 28.69  ? 173 LYS A C   1 ? 
ATOM   1334 O O   . LYS A 1 173 ? -8.833  -36.304 18.406 1.00 27.38  ? 173 LYS A O   1 ? 
ATOM   1335 C CB  . LYS A 1 173 ? -9.671  -37.868 15.632 1.00 25.03  ? 173 LYS A CB  1 ? 
ATOM   1336 C CG  . LYS A 1 173 ? -10.741 -38.420 14.720 1.00 28.84  ? 173 LYS A CG  1 ? 
ATOM   1337 C CD  . LYS A 1 173 ? -10.078 -38.582 13.382 1.00 36.74  ? 173 LYS A CD  1 ? 
ATOM   1338 C CE  . LYS A 1 173 ? -11.058 -38.602 12.238 1.00 52.24  ? 173 LYS A CE  1 ? 
ATOM   1339 N NZ  . LYS A 1 173 ? -10.400 -38.682 10.897 1.00 67.60  ? 173 LYS A NZ  1 ? 
ATOM   1340 N N   . PRO A 1 174 ? -7.774  -38.251 18.135 1.00 31.30  ? 174 PRO A N   1 ? 
ATOM   1341 C CA  . PRO A 1 174 ? -6.613  -37.778 18.899 1.00 30.87  ? 174 PRO A CA  1 ? 
ATOM   1342 C C   . PRO A 1 174 ? -5.871  -36.669 18.170 1.00 30.88  ? 174 PRO A C   1 ? 
ATOM   1343 O O   . PRO A 1 174 ? -5.976  -36.522 16.950 1.00 29.31  ? 174 PRO A O   1 ? 
ATOM   1344 C CB  . PRO A 1 174 ? -5.732  -39.026 19.038 1.00 24.56  ? 174 PRO A CB  1 ? 
ATOM   1345 C CG  . PRO A 1 174 ? -6.588  -40.154 18.656 1.00 35.14  ? 174 PRO A CG  1 ? 
ATOM   1346 C CD  . PRO A 1 174 ? -7.601  -39.643 17.703 1.00 34.87  ? 174 PRO A CD  1 ? 
ATOM   1347 N N   . VAL A 1 175 ? -5.046  -35.942 18.943 1.00 26.78  ? 175 VAL A N   1 ? 
ATOM   1348 C CA  . VAL A 1 175 ? -4.413  -34.705 18.469 1.00 27.91  ? 175 VAL A CA  1 ? 
ATOM   1349 C C   . VAL A 1 175 ? -3.652  -34.941 17.175 1.00 30.01  ? 175 VAL A C   1 ? 
ATOM   1350 O O   . VAL A 1 175 ? -3.825  -34.218 16.178 1.00 25.67  ? 175 VAL A O   1 ? 
ATOM   1351 C CB  . VAL A 1 175 ? -3.490  -34.118 19.555 1.00 38.74  ? 175 VAL A CB  1 ? 
ATOM   1352 C CG1 . VAL A 1 175 ? -2.509  -33.067 18.966 1.00 32.57  ? 175 VAL A CG1 1 ? 
ATOM   1353 C CG2 . VAL A 1 175 ? -4.298  -33.498 20.694 1.00 35.06  ? 175 VAL A CG2 1 ? 
ATOM   1354 N N   . ALA A 1 176 ? -2.814  -35.972 17.147 1.00 29.14  ? 176 ALA A N   1 ? 
ATOM   1355 C CA  . ALA A 1 176 ? -2.037  -36.210 15.931 1.00 27.94  ? 176 ALA A CA  1 ? 
ATOM   1356 C C   . ALA A 1 176 ? -2.935  -36.500 14.743 1.00 25.82  ? 176 ALA A C   1 ? 
ATOM   1357 O O   . ALA A 1 176 ? -2.615  -36.124 13.606 1.00 28.83  ? 176 ALA A O   1 ? 
ATOM   1358 C CB  . ALA A 1 176 ? -1.069  -37.366 16.128 1.00 35.30  ? 176 ALA A CB  1 ? 
ATOM   1359 N N   . GLU A 1 177 ? -4.031  -37.223 14.966 1.00 27.67  ? 177 GLU A N   1 ? 
ATOM   1360 C CA  . GLU A 1 177 ? -4.903  -37.549 13.846 1.00 33.04  ? 177 GLU A CA  1 ? 
ATOM   1361 C C   . GLU A 1 177 ? -5.654  -36.318 13.366 1.00 29.31  ? 177 GLU A C   1 ? 
ATOM   1362 O O   . GLU A 1 177 ? -5.968  -36.206 12.175 1.00 35.19  ? 177 GLU A O   1 ? 
ATOM   1363 C CB  . GLU A 1 177 ? -5.908  -38.642 14.225 1.00 38.69  ? 177 GLU A CB  1 ? 
ATOM   1364 C CG  . GLU A 1 177 ? -5.358  -40.080 14.160 1.00 46.88  ? 177 GLU A CG  1 ? 
ATOM   1365 C CD  . GLU A 1 177 ? -6.342  -41.159 14.626 1.00 49.14  ? 177 GLU A CD  1 ? 
ATOM   1366 O OE1 . GLU A 1 177 ? -7.507  -41.173 14.154 1.00 47.07  ? 177 GLU A OE1 1 ? 
ATOM   1367 O OE2 . GLU A 1 177 ? -5.929  -42.015 15.447 1.00 53.73  ? 177 GLU A OE2 1 ? 
ATOM   1368 N N   . VAL A 1 178 ? -5.991  -35.402 14.270 1.00 26.96  ? 178 VAL A N   1 ? 
ATOM   1369 C CA  . VAL A 1 178 ? -6.644  -34.177 13.817 1.00 24.55  ? 178 VAL A CA  1 ? 
ATOM   1370 C C   . VAL A 1 178 ? -5.677  -33.372 12.963 1.00 27.41  ? 178 VAL A C   1 ? 
ATOM   1371 O O   . VAL A 1 178 ? -6.034  -32.873 11.889 1.00 23.54  ? 178 VAL A O   1 ? 
ATOM   1372 C CB  . VAL A 1 178 ? -7.154  -33.358 15.012 1.00 29.54  ? 178 VAL A CB  1 ? 
ATOM   1373 C CG1 . VAL A 1 178 ? -7.677  -31.997 14.521 1.00 29.51  ? 178 VAL A CG1 1 ? 
ATOM   1374 C CG2 . VAL A 1 178 ? -8.233  -34.190 15.767 1.00 26.21  ? 178 VAL A CG2 1 ? 
ATOM   1375 N N   . ARG A 1 179 ? -4.428  -33.257 13.427 1.00 27.67  ? 179 ARG A N   1 ? 
ATOM   1376 C CA  . ARG A 1 179 ? -3.366  -32.555 12.706 1.00 31.60  ? 179 ARG A CA  1 ? 
ATOM   1377 C C   . ARG A 1 179 ? -3.252  -33.069 11.287 1.00 31.11  ? 179 ARG A C   1 ? 
ATOM   1378 O O   . ARG A 1 179 ? -3.184  -32.289 10.323 1.00 26.81  ? 179 ARG A O   1 ? 
ATOM   1379 C CB  . ARG A 1 179 ? -2.036  -32.762 13.452 1.00 27.88  ? 179 ARG A CB  1 ? 
ATOM   1380 C CG  . ARG A 1 179 ? -0.797  -32.092 12.863 1.00 35.18  ? 179 ARG A CG  1 ? 
ATOM   1381 C CD  . ARG A 1 179 ? 0.413   -32.241 13.787 1.00 36.09  ? 179 ARG A CD  1 ? 
ATOM   1382 N NE  . ARG A 1 179 ? 1.597   -31.703 13.137 1.00 59.92  ? 179 ARG A NE  1 ? 
ATOM   1383 C CZ  . ARG A 1 179 ? 2.746   -31.456 13.755 1.00 66.50  ? 179 ARG A CZ  1 ? 
ATOM   1384 N NH1 . ARG A 1 179 ? 2.859   -31.700 15.054 1.00 61.60  ? 179 ARG A NH1 1 ? 
ATOM   1385 N NH2 . ARG A 1 179 ? 3.769   -30.943 13.078 1.00 54.87  ? 179 ARG A NH2 1 ? 
ATOM   1386 N N   . ALA A 1 180 ? -3.225  -34.392 11.148 1.00 26.18  ? 180 ALA A N   1 ? 
ATOM   1387 C CA  . ALA A 1 180 ? -3.018  -34.975 9.834  1.00 29.67  ? 180 ALA A CA  1 ? 
ATOM   1388 C C   . ALA A 1 180 ? -4.215  -34.718 8.920  1.00 35.53  ? 180 ALA A C   1 ? 
ATOM   1389 O O   . ALA A 1 180 ? -4.036  -34.483 7.721  1.00 35.67  ? 180 ALA A O   1 ? 
ATOM   1390 C CB  . ALA A 1 180 ? -2.732  -36.469 9.969  1.00 37.94  ? 180 ALA A CB  1 ? 
ATOM   1391 N N   . ASP A 1 181 ? -5.447  -34.755 9.462  1.00 37.34  ? 181 ASP A N   1 ? 
ATOM   1392 C CA  . ASP A 1 181 ? -6.628  -34.445 8.646  1.00 33.99  ? 181 ASP A CA  1 ? 
ATOM   1393 C C   . ASP A 1 181 ? -6.606  -32.979 8.208  1.00 34.71  ? 181 ASP A C   1 ? 
ATOM   1394 O O   . ASP A 1 181 ? -7.054  -32.646 7.104  1.00 39.76  ? 181 ASP A O   1 ? 
ATOM   1395 C CB  . ASP A 1 181 ? -7.941  -34.745 9.411  1.00 32.28  ? 181 ASP A CB  1 ? 
ATOM   1396 C CG  . ASP A 1 181 ? -8.202  -36.264 9.654  1.00 43.51  ? 181 ASP A CG  1 ? 
ATOM   1397 O OD1 . ASP A 1 181 ? -7.564  -37.125 9.025  1.00 45.36  ? 181 ASP A OD1 1 ? 
ATOM   1398 O OD2 . ASP A 1 181 ? -9.080  -36.595 10.497 1.00 50.76  ? 181 ASP A OD2 1 ? 
ATOM   1399 N N   . LEU A 1 182 ? -6.102  -32.083 9.071  1.00 30.65  ? 182 LEU A N   1 ? 
ATOM   1400 C CA  . LEU A 1 182 ? -5.999  -30.669 8.706  1.00 33.30  ? 182 LEU A CA  1 ? 
ATOM   1401 C C   . LEU A 1 182 ? -4.946  -30.464 7.624  1.00 32.08  ? 182 LEU A C   1 ? 
ATOM   1402 O O   . LEU A 1 182 ? -5.126  -29.640 6.725  1.00 39.37  ? 182 LEU A O   1 ? 
ATOM   1403 C CB  . LEU A 1 182 ? -5.656  -29.793 9.921  1.00 27.63  ? 182 LEU A CB  1 ? 
ATOM   1404 C CG  . LEU A 1 182 ? -6.715  -29.661 11.011 1.00 32.79  ? 182 LEU A CG  1 ? 
ATOM   1405 C CD1 . LEU A 1 182 ? -6.187  -28.940 12.256 1.00 27.71  ? 182 LEU A CD1 1 ? 
ATOM   1406 C CD2 . LEU A 1 182 ? -7.935  -28.947 10.458 1.00 30.12  ? 182 LEU A CD2 1 ? 
ATOM   1407 N N   . GLU A 1 183 ? -3.844  -31.211 7.687  1.00 40.12  ? 183 GLU A N   1 ? 
ATOM   1408 C CA  . GLU A 1 183 ? -2.832  -31.140 6.637  1.00 44.84  ? 183 GLU A CA  1 ? 
ATOM   1409 C C   . GLU A 1 183 ? -3.370  -31.662 5.305  1.00 44.45  ? 183 GLU A C   1 ? 
ATOM   1410 O O   . GLU A 1 183 ? -3.048  -31.114 4.240  1.00 52.24  ? 183 GLU A O   1 ? 
ATOM   1411 C CB  . GLU A 1 183 ? -1.590  -31.932 7.058  1.00 47.49  ? 183 GLU A CB  1 ? 
ATOM   1412 C CG  . GLU A 1 183 ? -0.850  -31.368 8.291  1.00 48.58  ? 183 GLU A CG  1 ? 
ATOM   1413 C CD  . GLU A 1 183 ? 0.651   -31.584 8.215  1.00 66.14  ? 183 GLU A CD  1 ? 
ATOM   1414 O OE1 . GLU A 1 183 ? 1.152   -31.730 7.084  1.00 58.71  ? 183 GLU A OE1 1 ? 
ATOM   1415 O OE2 . GLU A 1 183 ? 1.331   -31.587 9.271  1.00 60.45  ? 183 GLU A OE2 1 ? 
ATOM   1416 N N   . LYS A 1 184 ? -4.166  -32.732 5.322  1.00 41.24  ? 184 LYS A N   1 ? 
ATOM   1417 C CA  . LYS A 1 184 ? -4.780  -33.157 4.065  1.00 44.06  ? 184 LYS A CA  1 ? 
ATOM   1418 C C   . LYS A 1 184 ? -5.555  -32.015 3.421  1.00 52.46  ? 184 LYS A C   1 ? 
ATOM   1419 O O   . LYS A 1 184 ? -5.596  -31.904 2.192  1.00 42.43  ? 184 LYS A O   1 ? 
ATOM   1420 C CB  . LYS A 1 184 ? -5.711  -34.353 4.275  1.00 48.99  ? 184 LYS A CB  1 ? 
ATOM   1421 C CG  . LYS A 1 184 ? -5.024  -35.574 4.880  1.00 68.89  ? 184 LYS A CG  1 ? 
ATOM   1422 C CD  . LYS A 1 184 ? -5.650  -36.916 4.469  1.00 64.90  ? 184 LYS A CD  1 ? 
ATOM   1423 C CE  . LYS A 1 184 ? -5.812  -37.844 5.693  1.00 61.15  ? 184 LYS A CE  1 ? 
ATOM   1424 N NZ  . LYS A 1 184 ? -4.529  -38.104 6.462  1.00 61.40  ? 184 LYS A NZ  1 ? 
ATOM   1425 N N   . ILE A 1 185 ? -6.160  -31.155 4.240  1.00 45.35  ? 185 ILE A N   1 ? 
ATOM   1426 C CA  . ILE A 1 185 ? -6.964  -30.053 3.736  1.00 36.11  ? 185 ILE A CA  1 ? 
ATOM   1427 C C   . ILE A 1 185 ? -6.080  -28.923 3.244  1.00 35.84  ? 185 ILE A C   1 ? 
ATOM   1428 O O   . ILE A 1 185 ? -6.293  -28.377 2.164  1.00 37.91  ? 185 ILE A O   1 ? 
ATOM   1429 C CB  . ILE A 1 185 ? -7.939  -29.589 4.837  1.00 36.12  ? 185 ILE A CB  1 ? 
ATOM   1430 C CG1 . ILE A 1 185 ? -8.989  -30.698 4.974  1.00 39.46  ? 185 ILE A CG1 1 ? 
ATOM   1431 C CG2 . ILE A 1 185 ? -8.555  -28.262 4.472  1.00 32.13  ? 185 ILE A CG2 1 ? 
ATOM   1432 C CD1 . ILE A 1 185 ? -9.768  -30.766 6.245  1.00 41.97  ? 185 ILE A CD1 1 ? 
ATOM   1433 N N   . LEU A 1 186 ? -5.064  -28.561 4.020  1.00 39.10  ? 186 LEU A N   1 ? 
ATOM   1434 C CA  . LEU A 1 186 ? -4.346  -27.317 3.771  1.00 40.48  ? 186 LEU A CA  1 ? 
ATOM   1435 C C   . LEU A 1 186 ? -3.212  -27.500 2.789  1.00 49.45  ? 186 LEU A C   1 ? 
ATOM   1436 O O   . LEU A 1 186 ? -2.857  -26.568 2.060  1.00 58.54  ? 186 LEU A O   1 ? 
ATOM   1437 C CB  . LEU A 1 186 ? -3.777  -26.780 5.078  1.00 32.41  ? 186 LEU A CB  1 ? 
ATOM   1438 C CG  . LEU A 1 186 ? -4.760  -26.354 6.146  1.00 33.57  ? 186 LEU A CG  1 ? 
ATOM   1439 C CD1 . LEU A 1 186 ? -3.981  -26.061 7.384  1.00 35.37  ? 186 LEU A CD1 1 ? 
ATOM   1440 C CD2 . LEU A 1 186 ? -5.528  -25.123 5.657  1.00 32.03  ? 186 LEU A CD2 1 ? 
ATOM   1441 N N   . GLY A 1 187 ? -2.592  -28.664 2.817  1.00 52.58  ? 187 GLY A N   1 ? 
ATOM   1442 C CA  . GLY A 1 187 ? -1.511  -28.971 1.914  1.00 62.12  ? 187 GLY A CA  1 ? 
ATOM   1443 C C   . GLY A 1 187 ? -2.090  -29.387 0.585  1.00 75.03  ? 187 GLY A C   1 ? 
ATOM   1444 O O   . GLY A 1 187 ? -3.257  -29.788 0.490  1.00 62.44  ? 187 GLY A O   1 ? 
ATOM   1445 O OXT . GLY A 1 187 ? -1.392  -29.317 -0.421 1.00 103.40 ? 187 GLY A OXT 1 ? 
HETATM 1446 P PA  . AP5 B 2 .   ? -8.072  -26.147 23.320 1.00 25.39  ? 301 AP5 A PA  1 ? 
HETATM 1447 O O1A . AP5 B 2 .   ? -7.219  -26.141 22.150 1.00 26.64  ? 301 AP5 A O1A 1 ? 
HETATM 1448 O O2A . AP5 B 2 .   ? -7.548  -25.144 24.317 1.00 30.05  ? 301 AP5 A O2A 1 ? 
HETATM 1449 O O3A . AP5 B 2 .   ? -9.506  -25.719 22.847 1.00 31.65  ? 301 AP5 A O3A 1 ? 
HETATM 1450 P PB  . AP5 B 2 .   ? -9.777  -24.254 22.229 1.00 42.64  ? 301 AP5 A PB  1 ? 
HETATM 1451 O O1B . AP5 B 2 .   ? -10.528 -24.442 21.041 1.00 33.65  ? 301 AP5 A O1B 1 ? 
HETATM 1452 O O2B . AP5 B 2 .   ? -8.510  -23.453 22.052 1.00 27.97  ? 301 AP5 A O2B 1 ? 
HETATM 1453 O O3B . AP5 B 2 .   ? -10.674 -23.473 23.307 1.00 38.14  ? 301 AP5 A O3B 1 ? 
HETATM 1454 P PG  . AP5 B 2 .   ? -10.121 -22.738 24.681 1.00 88.24  ? 301 AP5 A PG  1 ? 
HETATM 1455 O O1G . AP5 B 2 .   ? -8.935  -21.850 24.515 1.00 62.66  ? 301 AP5 A O1G 1 ? 
HETATM 1456 O O2G . AP5 B 2 .   ? -9.817  -23.733 25.804 1.00 78.59  ? 301 AP5 A O2G 1 ? 
HETATM 1457 O O3G . AP5 B 2 .   ? -11.359 -21.831 25.146 1.00 73.87  ? 301 AP5 A O3G 1 ? 
HETATM 1458 P PD  . AP5 B 2 .   ? -11.555 -20.518 24.183 1.00 79.57  ? 301 AP5 A PD  1 ? 
HETATM 1459 O O1D . AP5 B 2 .   ? -12.947 -20.483 23.868 1.00 62.37  ? 301 AP5 A O1D 1 ? 
HETATM 1460 O O2D . AP5 B 2 .   ? -10.612 -20.549 23.131 1.00 73.82  ? 301 AP5 A O2D 1 ? 
HETATM 1461 O O3D . AP5 B 2 .   ? -11.376 -19.297 25.089 1.00 43.62  ? 301 AP5 A O3D 1 ? 
HETATM 1462 P PE  . AP5 B 2 .   ? -11.429 -17.962 24.313 1.00 39.09  ? 301 AP5 A PE  1 ? 
HETATM 1463 O O1E . AP5 B 2 .   ? -11.605 -18.145 22.929 1.00 37.58  ? 301 AP5 A O1E 1 ? 
HETATM 1464 O O2E . AP5 B 2 .   ? -10.051 -17.601 24.721 1.00 44.09  ? 301 AP5 A O2E 1 ? 
HETATM 1465 O O5F . AP5 B 2 .   ? -8.109  -27.644 23.971 1.00 31.61  ? 301 AP5 A O5F 1 ? 
HETATM 1466 C C5F . AP5 B 2 .   ? -8.967  -27.841 25.014 1.00 28.53  ? 301 AP5 A C5F 1 ? 
HETATM 1467 C C4F . AP5 B 2 .   ? -8.578  -29.025 25.880 1.00 31.03  ? 301 AP5 A C4F 1 ? 
HETATM 1468 O O4F . AP5 B 2 .   ? -8.602  -30.295 25.127 1.00 27.65  ? 301 AP5 A O4F 1 ? 
HETATM 1469 C C3F . AP5 B 2 .   ? -7.092  -28.877 26.208 1.00 26.53  ? 301 AP5 A C3F 1 ? 
HETATM 1470 O O3F . AP5 B 2 .   ? -6.927  -29.361 27.561 1.00 47.42  ? 301 AP5 A O3F 1 ? 
HETATM 1471 C C2F . AP5 B 2 .   ? -6.429  -29.726 25.164 1.00 31.89  ? 301 AP5 A C2F 1 ? 
HETATM 1472 O O2F . AP5 B 2 .   ? -5.121  -30.202 25.646 1.00 34.42  ? 301 AP5 A O2F 1 ? 
HETATM 1473 C C1F . AP5 B 2 .   ? -7.271  -30.721 24.956 1.00 28.87  ? 301 AP5 A C1F 1 ? 
HETATM 1474 N N9A . AP5 B 2 .   ? -7.345  -31.272 23.606 1.00 30.41  ? 301 AP5 A N9A 1 ? 
HETATM 1475 C C8A . AP5 B 2 .   ? -7.098  -30.575 22.534 1.00 30.18  ? 301 AP5 A C8A 1 ? 
HETATM 1476 N N7A . AP5 B 2 .   ? -7.282  -31.356 21.470 1.00 35.58  ? 301 AP5 A N7A 1 ? 
HETATM 1477 C C5A . AP5 B 2 .   ? -7.672  -32.535 21.862 1.00 27.31  ? 301 AP5 A C5A 1 ? 
HETATM 1478 C C6A . AP5 B 2 .   ? -8.003  -33.701 21.190 1.00 26.94  ? 301 AP5 A C6A 1 ? 
HETATM 1479 N N6A . AP5 B 2 .   ? -8.003  -33.960 19.745 1.00 28.43  ? 301 AP5 A N6A 1 ? 
HETATM 1480 N N1A . AP5 B 2 .   ? -8.360  -34.754 21.845 1.00 23.49  ? 301 AP5 A N1A 1 ? 
HETATM 1481 C C2A . AP5 B 2 .   ? -8.425  -34.721 23.180 1.00 25.20  ? 301 AP5 A C2A 1 ? 
HETATM 1482 N N3A . AP5 B 2 .   ? -8.102  -33.606 23.842 1.00 27.99  ? 301 AP5 A N3A 1 ? 
HETATM 1483 C C4A . AP5 B 2 .   ? -7.721  -32.498 23.176 1.00 36.71  ? 301 AP5 A C4A 1 ? 
HETATM 1484 O O5J . AP5 B 2 .   ? -12.563 -16.995 24.904 1.00 33.12  ? 301 AP5 A O5J 1 ? 
HETATM 1485 C C5J . AP5 B 2 .   ? -12.414 -16.599 26.152 1.00 36.44  ? 301 AP5 A C5J 1 ? 
HETATM 1486 C C4J . AP5 B 2 .   ? -13.392 -15.441 26.419 1.00 24.64  ? 301 AP5 A C4J 1 ? 
HETATM 1487 O O4J . AP5 B 2 .   ? -12.997 -14.197 25.811 1.00 22.64  ? 301 AP5 A O4J 1 ? 
HETATM 1488 C C3J . AP5 B 2 .   ? -14.693 -15.681 25.718 1.00 25.65  ? 301 AP5 A C3J 1 ? 
HETATM 1489 O O3J . AP5 B 2 .   ? -15.582 -16.478 26.496 1.00 29.57  ? 301 AP5 A O3J 1 ? 
HETATM 1490 C C2J . AP5 B 2 .   ? -15.157 -14.214 25.565 1.00 35.14  ? 301 AP5 A C2J 1 ? 
HETATM 1491 O O2J . AP5 B 2 .   ? -15.555 -13.735 26.873 1.00 27.97  ? 301 AP5 A O2J 1 ? 
HETATM 1492 C C1J . AP5 B 2 .   ? -14.096 -13.598 25.210 1.00 24.45  ? 301 AP5 A C1J 1 ? 
HETATM 1493 N N9B . AP5 B 2 .   ? -13.867 -13.565 23.808 1.00 17.81  ? 301 AP5 A N9B 1 ? 
HETATM 1494 C C8B . AP5 B 2 .   ? -12.881 -14.106 23.209 1.00 19.91  ? 301 AP5 A C8B 1 ? 
HETATM 1495 N N7B . AP5 B 2 .   ? -13.014 -13.865 21.963 1.00 19.24  ? 301 AP5 A N7B 1 ? 
HETATM 1496 C C5B . AP5 B 2 .   ? -14.068 -13.159 21.755 1.00 20.63  ? 301 AP5 A C5B 1 ? 
HETATM 1497 C C6B . AP5 B 2 .   ? -14.634 -12.662 20.618 1.00 17.83  ? 301 AP5 A C6B 1 ? 
HETATM 1498 N N6B . AP5 B 2 .   ? -14.041 -12.821 19.289 1.00 21.32  ? 301 AP5 A N6B 1 ? 
HETATM 1499 N N1B . AP5 B 2 .   ? -15.736 -11.983 20.668 1.00 18.35  ? 301 AP5 A N1B 1 ? 
HETATM 1500 C C2B . AP5 B 2 .   ? -16.305 -11.770 21.864 1.00 25.13  ? 301 AP5 A C2B 1 ? 
HETATM 1501 N N3B . AP5 B 2 .   ? -15.770 -12.264 22.979 1.00 19.62  ? 301 AP5 A N3B 1 ? 
HETATM 1502 C C4B . AP5 B 2 .   ? -14.628 -12.961 22.926 1.00 21.19  ? 301 AP5 A C4B 1 ? 
HETATM 1503 O O   . HOH C 3 .   ? -16.981 1.775   17.596 1.00 40.89  ? 401 HOH A O   1 ? 
HETATM 1504 O O   . HOH C 3 .   ? -22.764 -6.168  16.914 1.00 32.26  ? 402 HOH A O   1 ? 
HETATM 1505 O O   . HOH C 3 .   ? -16.872 -37.514 32.673 1.00 47.64  ? 403 HOH A O   1 ? 
HETATM 1506 O O   . HOH C 3 .   ? -20.855 -29.075 20.407 1.00 37.10  ? 404 HOH A O   1 ? 
HETATM 1507 O O   . HOH C 3 .   ? -10.577 -22.412 36.775 1.00 47.22  ? 405 HOH A O   1 ? 
HETATM 1508 O O   . HOH C 3 .   ? -6.773  -22.776 24.148 1.00 41.28  ? 406 HOH A O   1 ? 
HETATM 1509 O O   . HOH C 3 .   ? -18.610 -27.691 14.593 1.00 40.59  ? 407 HOH A O   1 ? 
HETATM 1510 O O   . HOH C 3 .   ? -6.633  -17.349 35.233 1.00 55.66  ? 408 HOH A O   1 ? 
HETATM 1511 O O   . HOH C 3 .   ? -30.037 -16.545 19.855 1.00 33.24  ? 409 HOH A O   1 ? 
HETATM 1512 O O   . HOH C 3 .   ? -5.324  -11.705 32.013 1.00 35.57  ? 410 HOH A O   1 ? 
HETATM 1513 O O   . HOH C 3 .   ? -2.092  -35.242 6.468  1.00 44.66  ? 411 HOH A O   1 ? 
HETATM 1514 O O   . HOH C 3 .   ? -24.682 -9.961  7.316  1.00 49.37  ? 412 HOH A O   1 ? 
HETATM 1515 O O   . HOH C 3 .   ? -9.687  3.154   31.677 1.00 47.60  ? 413 HOH A O   1 ? 
HETATM 1516 O O   . HOH C 3 .   ? 1.928   -12.666 1.121  1.00 51.20  ? 414 HOH A O   1 ? 
HETATM 1517 O O   . HOH C 3 .   ? -6.051  -38.404 10.474 1.00 35.93  ? 415 HOH A O   1 ? 
HETATM 1518 O O   . HOH C 3 .   ? -8.352  -19.481 24.786 1.00 48.32  ? 416 HOH A O   1 ? 
HETATM 1519 O O   . HOH C 3 .   ? 2.412   -16.532 4.145  1.00 59.46  ? 417 HOH A O   1 ? 
HETATM 1520 O O   . HOH C 3 .   ? -10.490 -15.637 29.311 1.00 36.36  ? 418 HOH A O   1 ? 
HETATM 1521 O O   . HOH C 3 .   ? -9.578  -42.361 14.807 1.00 40.33  ? 419 HOH A O   1 ? 
HETATM 1522 O O   . HOH C 3 .   ? -9.066  -4.014  6.005  1.00 55.18  ? 420 HOH A O   1 ? 
HETATM 1523 O O   . HOH C 3 .   ? -12.735 -38.354 21.544 1.00 33.96  ? 421 HOH A O   1 ? 
HETATM 1524 O O   . HOH C 3 .   ? -23.903 -13.043 23.009 1.00 43.08  ? 422 HOH A O   1 ? 
HETATM 1525 O O   . HOH C 3 .   ? -1.003  -1.050  25.980 1.00 42.14  ? 423 HOH A O   1 ? 
HETATM 1526 O O   . HOH C 3 .   ? -14.156 -11.998 5.048  1.00 35.46  ? 424 HOH A O   1 ? 
HETATM 1527 O O   . HOH C 3 .   ? -17.210 -34.987 15.313 1.00 38.85  ? 425 HOH A O   1 ? 
HETATM 1528 O O   . HOH C 3 .   ? -17.456 -27.472 17.585 1.00 37.27  ? 426 HOH A O   1 ? 
HETATM 1529 O O   . HOH C 3 .   ? -6.435  -3.213  10.308 1.00 34.94  ? 427 HOH A O   1 ? 
HETATM 1530 O O   . HOH C 3 .   ? -9.979  -31.334 18.244 1.00 28.67  ? 428 HOH A O   1 ? 
HETATM 1531 O O   . HOH C 3 .   ? 5.695   -12.631 6.484  1.00 49.04  ? 429 HOH A O   1 ? 
HETATM 1532 O O   . HOH C 3 .   ? 2.387   -12.644 8.032  1.00 33.23  ? 430 HOH A O   1 ? 
HETATM 1533 O O   . HOH C 3 .   ? -11.878 -18.259 15.090 1.00 27.13  ? 431 HOH A O   1 ? 
HETATM 1534 O O   . HOH C 3 .   ? -20.385 -28.098 8.514  1.00 35.05  ? 432 HOH A O   1 ? 
HETATM 1535 O O   . HOH C 3 .   ? -10.868 -19.681 20.663 1.00 38.63  ? 433 HOH A O   1 ? 
HETATM 1536 O O   . HOH C 3 .   ? -1.006  -1.994  7.876  1.00 42.82  ? 434 HOH A O   1 ? 
HETATM 1537 O O   . HOH C 3 .   ? -9.447  -37.328 21.367 1.00 30.13  ? 435 HOH A O   1 ? 
HETATM 1538 O O   . HOH C 3 .   ? -9.233  -21.204 20.701 1.00 32.67  ? 436 HOH A O   1 ? 
HETATM 1539 O O   . HOH C 3 .   ? -14.639 -18.368 16.193 1.00 30.87  ? 437 HOH A O   1 ? 
HETATM 1540 O O   . HOH C 3 .   ? -9.674  -16.539 21.215 1.00 27.72  ? 438 HOH A O   1 ? 
HETATM 1541 O O   . HOH C 3 .   ? 5.118   -6.455  12.564 1.00 45.64  ? 439 HOH A O   1 ? 
HETATM 1542 O O   . HOH C 3 .   ? -19.974 -10.306 20.938 1.00 28.40  ? 440 HOH A O   1 ? 
HETATM 1543 O O   . HOH C 3 .   ? -8.921  -20.142 -0.706 1.00 36.25  ? 441 HOH A O   1 ? 
HETATM 1544 O O   . HOH C 3 .   ? 4.089   -23.133 16.090 1.00 28.94  ? 442 HOH A O   1 ? 
HETATM 1545 O O   . HOH C 3 .   ? -4.529  -5.308  19.026 1.00 26.18  ? 443 HOH A O   1 ? 
HETATM 1546 O O   . HOH C 3 .   ? -20.610 -5.587  12.229 1.00 34.26  ? 444 HOH A O   1 ? 
HETATM 1547 O O   . HOH C 3 .   ? -4.563  -36.576 21.533 1.00 36.37  ? 445 HOH A O   1 ? 
HETATM 1548 O O   . HOH C 3 .   ? 5.345   -24.988 16.876 1.00 29.65  ? 446 HOH A O   1 ? 
HETATM 1549 O O   . HOH C 3 .   ? -13.753 -40.664 14.599 1.00 34.14  ? 447 HOH A O   1 ? 
HETATM 1550 O O   . HOH C 3 .   ? -8.846  -34.419 6.088  1.00 49.14  ? 448 HOH A O   1 ? 
HETATM 1551 O O   . HOH C 3 .   ? -2.453  -13.620 26.542 1.00 36.98  ? 449 HOH A O   1 ? 
HETATM 1552 O O   . HOH C 3 .   ? -23.219 -19.272 -1.659 1.00 33.41  ? 450 HOH A O   1 ? 
HETATM 1553 O O   . HOH C 3 .   ? -24.166 -14.094 15.603 1.00 21.89  ? 451 HOH A O   1 ? 
HETATM 1554 O O   . HOH C 3 .   ? -3.673  -7.277  24.016 1.00 35.81  ? 452 HOH A O   1 ? 
HETATM 1555 O O   . HOH C 3 .   ? -17.923 -4.326  35.223 1.00 49.87  ? 453 HOH A O   1 ? 
HETATM 1556 O O   . HOH C 3 .   ? -9.884  -16.105 -0.313 1.00 36.32  ? 454 HOH A O   1 ? 
HETATM 1557 O O   . HOH C 3 .   ? -17.886 -37.615 30.175 1.00 38.40  ? 455 HOH A O   1 ? 
HETATM 1558 O O   . HOH C 3 .   ? 4.580   -14.204 7.892  1.00 39.63  ? 456 HOH A O   1 ? 
HETATM 1559 O O   . HOH C 3 .   ? -15.224 -16.720 29.245 1.00 26.74  ? 457 HOH A O   1 ? 
HETATM 1560 O O   . HOH C 3 .   ? -2.985  -28.368 13.125 1.00 40.04  ? 458 HOH A O   1 ? 
HETATM 1561 O O   . HOH C 3 .   ? -2.092  -37.692 19.232 1.00 35.22  ? 459 HOH A O   1 ? 
HETATM 1562 O O   . HOH C 3 .   ? -0.057  -8.153  28.859 1.00 40.06  ? 460 HOH A O   1 ? 
HETATM 1563 O O   . HOH C 3 .   ? -2.570  -21.746 20.560 1.00 47.22  ? 461 HOH A O   1 ? 
HETATM 1564 O O   . HOH C 3 .   ? -14.861 -1.144  16.826 1.00 29.11  ? 462 HOH A O   1 ? 
HETATM 1565 O O   . HOH C 3 .   ? -21.430 -29.066 11.197 1.00 47.08  ? 463 HOH A O   1 ? 
HETATM 1566 O O   . HOH C 3 .   ? -14.640 -25.208 0.071  1.00 30.47  ? 464 HOH A O   1 ? 
HETATM 1567 O O   . HOH C 3 .   ? -21.719 -6.716  20.862 1.00 32.34  ? 465 HOH A O   1 ? 
HETATM 1568 O O   . HOH C 3 .   ? -16.349 -20.850 16.244 1.00 26.35  ? 466 HOH A O   1 ? 
HETATM 1569 O O   . HOH C 3 .   ? -0.128  -27.649 20.380 1.00 32.70  ? 467 HOH A O   1 ? 
HETATM 1570 O O   . HOH C 3 .   ? -16.185 -12.714 6.977  1.00 25.96  ? 468 HOH A O   1 ? 
HETATM 1571 O O   . HOH C 3 .   ? -14.383 -5.767  33.603 1.00 45.36  ? 469 HOH A O   1 ? 
HETATM 1572 O O   . HOH C 3 .   ? -7.118  -31.032 18.549 1.00 27.15  ? 470 HOH A O   1 ? 
HETATM 1573 O O   . HOH C 3 .   ? -19.629 -24.977 1.408  1.00 39.42  ? 471 HOH A O   1 ? 
HETATM 1574 O O   . HOH C 3 .   ? -2.869  -13.734 19.525 1.00 32.67  ? 472 HOH A O   1 ? 
HETATM 1575 O O   . HOH C 3 .   ? -15.474 -38.948 11.712 1.00 44.18  ? 473 HOH A O   1 ? 
HETATM 1576 O O   . HOH C 3 .   ? -8.240  -40.528 11.198 1.00 51.67  ? 474 HOH A O   1 ? 
HETATM 1577 O O   . HOH C 3 .   ? -24.239 -25.962 28.226 1.00 39.92  ? 475 HOH A O   1 ? 
HETATM 1578 O O   . HOH C 3 .   ? -8.569  -0.540  16.356 1.00 32.43  ? 476 HOH A O   1 ? 
HETATM 1579 O O   . HOH C 3 .   ? -15.549 -3.363  9.289  1.00 32.70  ? 477 HOH A O   1 ? 
HETATM 1580 O O   . HOH C 3 .   ? -7.085  -10.253 3.678  1.00 48.92  ? 478 HOH A O   1 ? 
HETATM 1581 O O   . HOH C 3 .   ? -18.521 -18.785 21.389 1.00 23.98  ? 479 HOH A O   1 ? 
HETATM 1582 O O   . HOH C 3 .   ? -12.101 -35.466 10.233 1.00 36.22  ? 480 HOH A O   1 ? 
HETATM 1583 O O   . HOH C 3 .   ? -23.948 -7.037  11.012 1.00 36.96  ? 481 HOH A O   1 ? 
HETATM 1584 O O   . HOH C 3 .   ? -20.379 -7.843  26.752 1.00 38.35  ? 482 HOH A O   1 ? 
HETATM 1585 O O   . HOH C 3 .   ? 1.300   -15.456 17.141 1.00 36.58  ? 483 HOH A O   1 ? 
HETATM 1586 O O   . HOH C 3 .   ? -12.971 -40.348 17.455 1.00 27.33  ? 484 HOH A O   1 ? 
HETATM 1587 O O   . HOH C 3 .   ? -15.253 -31.133 5.143  1.00 34.27  ? 485 HOH A O   1 ? 
HETATM 1588 O O   . HOH C 3 .   ? -14.958 -23.241 -2.390 1.00 37.93  ? 486 HOH A O   1 ? 
HETATM 1589 O O   . HOH C 3 .   ? -4.895  0.026   24.372 1.00 42.73  ? 487 HOH A O   1 ? 
HETATM 1590 O O   . HOH C 3 .   ? -18.781 -21.656 15.053 1.00 30.47  ? 488 HOH A O   1 ? 
HETATM 1591 O O   . HOH C 3 .   ? -20.789 -27.293 5.111  1.00 46.73  ? 489 HOH A O   1 ? 
HETATM 1592 O O   . HOH C 3 .   ? -4.758  2.224   17.204 1.00 50.97  ? 490 HOH A O   1 ? 
HETATM 1593 O O   . HOH C 3 .   ? -17.505 -19.099 38.285 1.00 41.89  ? 491 HOH A O   1 ? 
HETATM 1594 O O   . HOH C 3 .   ? -18.150 -35.136 12.683 1.00 43.93  ? 492 HOH A O   1 ? 
HETATM 1595 O O   . HOH C 3 .   ? 2.806   -12.956 17.237 1.00 40.53  ? 493 HOH A O   1 ? 
HETATM 1596 O O   . HOH C 3 .   ? 3.543   -28.227 11.438 1.00 36.24  ? 494 HOH A O   1 ? 
HETATM 1597 O O   . HOH C 3 .   ? -9.911  -13.329 36.175 1.00 43.16  ? 495 HOH A O   1 ? 
HETATM 1598 O O   . HOH C 3 .   ? -23.621 -31.518 21.058 1.00 39.58  ? 496 HOH A O   1 ? 
HETATM 1599 O O   . HOH C 3 .   ? -3.640  -16.359 27.581 1.00 36.97  ? 497 HOH A O   1 ? 
HETATM 1600 O O   . HOH C 3 .   ? -22.090 -15.414 4.199  1.00 35.84  ? 498 HOH A O   1 ? 
HETATM 1601 O O   . HOH C 3 .   ? -20.779 -3.776  19.824 1.00 28.27  ? 499 HOH A O   1 ? 
HETATM 1602 O O   . HOH C 3 .   ? -22.518 -11.094 4.966  1.00 51.49  ? 500 HOH A O   1 ? 
HETATM 1603 O O   . HOH C 3 .   ? 0.324   -35.828 12.647 1.00 38.90  ? 501 HOH A O   1 ? 
HETATM 1604 O O   . HOH C 3 .   ? 4.427   -10.077 -2.084 1.00 52.82  ? 502 HOH A O   1 ? 
HETATM 1605 O O   . HOH C 3 .   ? -15.641 -20.050 19.605 1.00 35.23  ? 503 HOH A O   1 ? 
HETATM 1606 O O   . HOH C 3 .   ? -14.434 -10.925 2.293  1.00 42.38  ? 504 HOH A O   1 ? 
HETATM 1607 O O   . HOH C 3 .   ? -11.479 -20.172 -2.391 1.00 49.35  ? 505 HOH A O   1 ? 
HETATM 1608 O O   . HOH C 3 .   ? -10.603 -41.234 17.372 1.00 35.94  ? 506 HOH A O   1 ? 
HETATM 1609 O O   . HOH C 3 .   ? -11.689 -2.390  1.310  1.00 51.51  ? 507 HOH A O   1 ? 
HETATM 1610 O O   . HOH C 3 .   ? -29.227 -15.058 21.523 1.00 42.49  ? 508 HOH A O   1 ? 
HETATM 1611 O O   . HOH C 3 .   ? -12.539 -26.831 -0.399 1.00 43.99  ? 509 HOH A O   1 ? 
HETATM 1612 O O   . HOH C 3 .   ? -22.229 -5.279  10.430 1.00 48.20  ? 510 HOH A O   1 ? 
HETATM 1613 O O   . HOH C 3 .   ? -12.619 -4.763  -0.315 1.00 48.95  ? 511 HOH A O   1 ? 
HETATM 1614 O O   . HOH C 3 .   ? -24.603 -31.839 27.302 1.00 43.87  ? 512 HOH A O   1 ? 
HETATM 1615 O O   . HOH C 3 .   ? -17.638 -26.234 -0.046 1.00 55.66  ? 513 HOH A O   1 ? 
HETATM 1616 O O   . HOH C 3 .   ? -12.859 -32.104 3.542  1.00 46.44  ? 514 HOH A O   1 ? 
# 
